CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_000918	Aquifex aeolicus VF5, complete sequence	10 crisprs	DinG,cas2,cas1,cas4,cas3,cas8b2,cas5,cas7,csx3,csm6,cmr6gr7,cmr4gr7,cmr1gr7,cas6,cmr5gr11,cmr3gr5,cas10,cas14k,DEDDh,csa3,cas3HD	0	3	0	0
NC_001880	Aquifex aeolicus VF5 plasmid ece1, complete sequence	1 crisprs	Cas14b_CAS-V-F	0	6	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_000918_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_000918_1

156460-156768

Orphan

Consensus_repeat	Method
GTTCCTAATGTACCGT-GTGGAGTTGAAACC	PILER-CR
GTTCCTAATGTACCGTGTGGAGTTGAAACCT	CRISPRCasFinder
GTTCCTAATGTACCGTGTGGANNTNAAANCT	CRT

4 spacers

The CRISPR arrays of NC_000918_1

>merge|NC_000918|1|156460-156768|PILER-CR,CRISPRCasFinder,CRT
GTTCCTAATGTACCGTGTGGAGTTGAAACCCAGTCAGATTGAAGTTATCGTCAACTTCAAAATACGGTTCCTAATGTACCGTGTGGAGTTGAAACCTTGCTTTATCAGAGAATAGTATTCTTTCTATGTCTTCATAGTTTGTTCCTAATGTACCGTGTGGAGTTGAAACCTCTTGATAGTATCTGTTTTCCGCGTATTCCACGATTCTTTTGTTCCTAATGTACCGTAGTGGAGTTGAAACTTCGGTGATAAAGGAGCATTTTTCACAAAAGAAATCAGTTTCTAATGTACCGTGTGGATAAAAATGAT

>NC_000918|1|1|156460-156701|PILER-CR
GTTCCTAATGTACCGTGTGGAGTTGAAACCC	AGTCAGATTGAAGTTATCGTCAACTTCAAAATACGG
TTCCTAATGTACCGTGTGGAGTTGAAACCTT	GCTTTATCAGAGAATAGTATTCTTTCTATGTCTTCATAGTTTGT
TCCTAATGTACCGTGTGGAGTTGAAACCTCT	TGATAGTATCTGTTTTCCGCGTATTCCACGATTCTTTTGTT
CCTAATGTACCGTAGTGGAGTTGAAACT

>NC_000918|1|1|156460-156768|CRISPRCasFinder
GTTCCTAATGTACCGTGTGGAGTTGAAACCC	AGTCAGATTGAAGTTATCGTCAACTTCAAAATACG
GTTCCTAATGTACCGTGTGGAGTTGAAACCT	TGCTTTATCAGAGAATAGTATTCTTTCTATGTCTTCATAGTTT
GTTCCTAATGTACCGTGTGGAGTTGAAACCT	CTTGATAGTATCTGTTTTCCGCGTATTCCACGATTCTTTT
GTTCCTAATGTACCGTAGTGGAGTTGAAACT	TCGGTGATAAAGGAGCATTTTTCACAAAAGAAATCA
GTTTCTAATGTACCGTGTGGATAAAAATGAT

>NC_000918|1|1|156460-156768|CRT
GTTCCTAATGTACCGTGTGGAGTTGAAACCC	AGTCAGATTGAAGTTATCGTCAACTTCAAAATACG
GTTCCTAATGTACCGTGTGGAGTTGAAACCT	TGCTTTATCAGAGAATAGTATTCTTTCTATGTCTTCATAGTTT
GTTCCTAATGTACCGTGTGGAGTTGAAACCT	CTTGATAGTATCTGTTTTCCGCGTATTCCACGATTCTTTT
GTTCCTAATGTACCGTAGTGGAGTTGAAACT	TCGGTGATAAAGGAGCATTTTTCACAAAAGAAATCA
GTTTCTAATGTACCGTGTGGATAAAAATGAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_000918.1\|WP_010880099.1\|147545_149078_-\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NC_000918.1\|WP_010880103.1\|151205_153593_+\|endopeptidase-La	unknown	unknown	gnl\|CDD\|223542
NC_000918.1\|WP_010880108.1\|158695_160132_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NC_000918.1\|WP_010880097.1\|145594_146311_+\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|239557
NC_000918.1\|WP_010880111.1\|161324_161744_-\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_010880102.1\|150270_151173_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NC_000918.1\|WP_010880105.1\|155053_156148_-\|3-isopropylmalate-dehydrogenase	unknown	unknown	gnl\|CDD\|234832
NC_000918.1\|WP_010880114.1\|163192_163678_+\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_010880109.1\|160144_160582_-\|TraR/DksA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224648
NC_000918.1\|WP_010880113.1\|162751_163159_+\|S-adenosylmethionine-decarboxylase	unknown	unknown	gnl\|CDD\|234926
NC_000918.1\|WP_010880110.1\|160628_161309_-\|N-glycosylase/DNA-lyase	unknown	unknown	gnl\|CDD\|223987
NC_000918.1\|WP_010880112.1\|161731_162217_-\|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|223741
NC_000918.1\|WP_164930575.1\|163681_164110_+\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_010880098.1\|146291_147545_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223523
NC_000918.1\|WP_010880104.1\|153579_155067_-\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_010880106.1\|156793_157891_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	unknown	unknown	gnl\|CDD\|273473
NC_000918.1\|WP_010880107.1\|157856_158696_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|274527
NC_000918.1\|WP_010880101.1\|149719_150274_+\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472
NC_000918.1\|WP_010880100.1\|149123_149639_+\|superoxide-dismutase-family-protein	unknown	unknown	gnl\|CDD\|224943
NC_000918.1\|WP_010880096.1\|144274_145585_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223523

Protein	Function_ID	Function_description	E-value
NC_000918.1\|WP_010880099.1\|147545_149078_-\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NC_000918.1\|WP_010880103.1\|151205_153593_+\|endopeptidase-La	gnl\|CDD\|223542	COG0466, Lon, ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones].	0
NC_000918.1\|WP_010880108.1\|158695_160132_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NC_000918.1\|WP_010880097.1\|145594_146311_+\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|239557	cd03475, Rieske_SoxF_SoxL, SoxF and SoxL family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. SoxF is a subunit of the terminal oxidase supercomplex SoxM in the plasma membrane of Sulfolobus acidocaldarius that combines features of a cytochrome bc(1) complex and a cytochrome. The Rieske domain of SoxF has a 12 residue insertion which is not found in eukaryotic and bacterial Rieske proteins and is thought to influence the redox properties of the iron-sulfur cluster. SoxL is a Rieske protein which may be part of an archaeal bc-complex homologue whose physiological function is still unknown. SoxL has two features not seen in other Rieske proteins; (i) a significantly greater distance between the two cluster-binding sites and (ii) an unexpected Pro -> Asp substitution at one of the cluster binding sites. SoxF and SoxL are found in archaea and in bacteria.	6.17698e-73
NC_000918.1\|WP_010880102.1\|150270_151173_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	4.68352e-99
NC_000918.1\|WP_010880105.1\|155053_156148_-\|3-isopropylmalate-dehydrogenase	gnl\|CDD\|234832	PRK00772, PRK00772, 3-isopropylmalate dehydrogenase; Provisional.	0
NC_000918.1\|WP_010880109.1\|160144_160582_-\|TraR/DksA-family-transcriptional-regulator	gnl\|CDD\|224648	COG1734, DksA, DnaK suppressor protein [Signal transduction mechanisms].	1.32625e-30
NC_000918.1\|WP_010880113.1\|162751_163159_+\|S-adenosylmethionine-decarboxylase	gnl\|CDD\|234926	PRK01236, PRK01236, S-adenosylmethionine decarboxylase proenzyme; Provisional.	3.26705e-82
NC_000918.1\|WP_010880110.1\|160628_161309_-\|N-glycosylase/DNA-lyase	gnl\|CDD\|223987	COG1059, COG1059, Thermostable 8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	3.08994e-92
NC_000918.1\|WP_010880112.1\|161731_162217_-\|pantetheine-phosphate-adenylyltransferase	gnl\|CDD\|223741	COG0669, CoaD, Phosphopantetheine adenylyltransferase [Coenzyme metabolism].	2.84989e-84
NC_000918.1\|WP_010880098.1\|146291_147545_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223523	COG0446, HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only].	1.47743e-40
NC_000918.1\|WP_010880106.1\|156793_157891_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	gnl\|CDD\|273473	TIGR01161, N5-carboxyaminoimidazole_ribonucleotide_synthase, phosphoribosylaminoimidazole carboxylase, PurK protein. Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. This model represents PurK, N5-carboxyaminoimidazole ribonucleotide synthetase, which hydrolyzes ATP and converts AIR to N5-CAIR. PurE converts N5-CAIR to CAIR. In the presence of high concentrations of bicarbonate, PurE is reported able to convert AIR to CAIR directly and without ATP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis].	0
NC_000918.1\|WP_010880107.1\|157856_158696_-\|DMT-family-transporter	gnl\|CDD\|274527	TIGR03340, phn_DUF6, phosphonate utilization associated putative membrane protein. This family of hydrophobic proteins has some homology to families of integral membrane proteins such as (pfam00892) and may be a permease. It occurs in the vicinity of various types of operons for the catabolism of phosphonates in Vibrio, Pseudomonas, Polaromonas and Thiomicrospira.	4.56925e-10
NC_000918.1\|WP_010880101.1\|149719_150274_+\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	8.54843e-110
NC_000918.1\|WP_010880100.1\|149123_149639_+\|superoxide-dismutase-family-protein	gnl\|CDD\|224943	COG2032, SodC, Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism].	1.83636e-60
NC_000918.1\|WP_010880096.1\|144274_145585_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|223523	COG0446, HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only].	3.80094e-38

>NC_000918.1|WP_010880105.1|155053_156148_-|3-isopropylmalate-dehydrogenase
MKKYKIAVLKGDGIGPEIVEQALRVLDKIGEIYGVEFEYREGLIGGEAIDKTGDPLPEETLKICKESDAILLGAVGGPKWDNLPTDKRPEKGLLRIRKELDLYANLRPAKVWDALISSSPLKEEVVKGTDMIVIRELTSGIYYGEPRGIFEENGKRYAINTMKYTEDEIRRIVRKGFEIARKRRKKLTSVDKANVLEVSALWRQIVEEEKENYPDVELEHLYIDNCAMQLVRRPTSFDVIVTGNIFGDILSDEAGVVVGSLGMLPSASIGDRYALYEPVHGSAPDIAGKGIANPIATILSAAMMLKYSFNMDKAHDLIEKAIEETLNQGYRTPDIYSEGCIKVGTKEITDKILENLERLKDAYT
>NC_000918.1|WP_010880104.1|153579_155067_-|hypothetical-protein
MRTLSLLILFLSTFLFAQVPKELLEFFQRSGYVVEKEGEKVLIDLPRGKAFPGEIFEVFQSKKPIIHPVTKKVLGYKEEKVGEVEVIKPRENFSEAKTLENNGIKPGDRVKLKIGSVCYIGGDEGYYALSQVVQNVKRNSENCDYVVKELENGYGVSYKGKPLAFFQYSGVGFAKRGGVFEDFALKAKFVRSLESLPLSADICKLFGKKDYLVVLFSDKVKVYEVLKTDFVEVLSYAIPTGYPVGVVCYENKGRSAVLVNMISNGEASSAVLSPVGNSLMLTDKNVPYLFGFFYQNGKKVLIGQEFKGSWGKVYRFELRGDKLVRKDALNLPEDFRVDGANAWNNVLVFVDNDGQLRVYVNDEEVLTEDGFGLSYTTAEVPGVYEYAEGDKYGFYVRPNFTKVYKDVLPLIAKNRASNIFQLVGFTKFTEGELWTVVRKKEKVYEAIKLKGRKFEEAIQAIVRDSEGRIFVITGSKGTIPIQNRGEVYLIEITPL
>NC_000918.1|WP_010880103.1|151205_153593_+|endopeptidase-La
MNELFQTPQVEAGIKEYPLMPLRDIVIFPTMVQPLFVGRRFSIRAIEEANKKDKLIFLVLQKDKDVEEPKEEDIYKVGVVAYILRTVPIEDARVKVLVQGLKRGVIKKLEWKEDHYVAQVDVIEERDIPPESQTIEDKALIKAVKESIDKLVSLGKQIIPDLVVLIKELEEPGKLADMVASILDIKSSQAQEILETFDPRERLKKVYKFLQDEIGLLEVKQRISEIARERMEKEQREYYLRQQLKAIQEELGEAGGIKAEIEEYTKKFEEVKECMPEEGVKEVEKNIKRLERLHPESAEAGVIRTWLDWVLDLPWCTRTEDNYDLERAREILDRDHYDLEKVKDRIIEYLAIRKLTQGKEAPTQILAFVGPPGVGKTSLGRSIAEALGRKFVRIALGGIRDEAEIRGHRRTYVGAMPGRIIQAIKQAGTKNPVIMLDEIDKLAISFQGDPAAALLEVLDPEQNKKFTDLYIGIPFDLSEVIFICTGNRADTIPTPLLDRMELIMLSGYSEEEKLFIAKKHLIPKLIPLHGFSPEEIEFTDEAILEIIRGYTREAGVRNLQRQISAVLRKIAVKKLQGEKGPFNITPELVRKLLGVPRYRPEREKKPLVGVATGLAWTEVGGEIMFIEATKMKGKGSLVLTGSLGDIMKESAQAALSYIRSKAEDYGIDPDIFSQVDVHVHVPEGAVPKDGPSAGVAIATALLSLFTDIPVRMDVAMTGEITLRGRVLPVGGLKEKILAAKRAEIYEVILPAKNKDEVMEELPEYVREKMTLHFVDNLEEVFKIALVREPKPLKEA
>NC_000918.1|WP_010880102.1|150270_151173_-|MoxR-family-ATPase
MDINLIISEVSKVIKGKEEVIKNSLVCLLSGGHLLIEDVPGTGKTTLALALARVLGLSFSRIQFTSDLLPSDITGVSVFNQKTREFEFKKGPIFSNVVLADEINRGTPKVQSALLEAMAEKQVSVDGNTYKLPEPFFVIATQNPIEYYGTYPLPEAQLDRFTMKISMGYPSEEDEVQIVQGINPMEKVSSLNVLSSPEEVIRTVNEVKEIYVSPEVARFIVNIGNEVRNHPSVILGVSTRGLIHLANASRALAYFRERDFVVPEDVLDLLKYVIPHRIKVREGVKAEAVLKEVISRVPIP
>NC_000918.1|WP_010880101.1|149719_150274_+|GTP-cyclohydrolase-I-FolE
MAIDKEKIKQAVRLFLEGIGEDPDREGLKETPERVARMWEEFERMRNFDMKLFEEFGGYNEMVLVKDIKFYSLCEHHLLPFFGKVHIAYIPDKKISGLSKLVRTVRAFALRPQVQERLTEEIADFLEKELEPKGVGVVIEAEHLCMSMRGVMSPGHLTVTSALRGVFLKDIKTREEFLKLVKGV
>NC_000918.1|WP_010880100.1|149123_149639_+|superoxide-dismutase-family-protein
MKKLSGVLAGSLLLISASFSQDLKAHAELINTEGEVIGKAELIETNSGVLIKLNAKGLPPNAELAFHIHERGECKPPTFKSAKGHFNPYGKKHGLLNPEGPHAGDMPNIYTDDKGNVRVQVLNPFVTLKKGEKNSLFKEGGTALVIHSGPDDYKSDPAGNAGKRIACGVIR
>NC_000918.1|WP_010880099.1|147545_149078_-|glutamine-hydrolyzing-GMP-synthase
MQRRPILVVNFGSQYVQLIARRVRELGVYSEIVHWDTPVEEIKKKNPYGIIFSGGPASVYAEGAPLPDKRIYELGVPILGICYGLQVITHQLGGKVVRSEKQEYGRARLRIIKEDVIFEGIPKESDVWMSHADKVVELPEGFEVLAVSENSPYAVIANREKKIYGFQFHPEVTHTVFGKEMLANFIYGVCKAEKNWEMGDFIHEKIEEIRKTVGDAKVIAALSGGVDSTVAAVLTHRAIGDKLHCFFIDHGLLRYKEREEVEKNLRSLGLPLTVVDASEEFLEKLKGVEDPEEKRKIIGRTFIEVFEREAKKIEGAEFLLQGTLYPDVVESAGIKGSAKIKTHHNVGGLPERMNLKLLEPFRELFKDEVRKIGKLLGVPEEILRRHPFPGPGLAIRIIGEVNKKDLEILRKADYIFIQELKKEGLYDRVWQAFAVLLPVKSVGVMGDVRTYEKVVALRAVESVDGMTADWARLPYDFLDRVMRRIINEVEGVNRVVYDISSKPPSTIEWE
>NC_000918.1|WP_010880098.1|146291_147545_+|NAD(P)/FAD-dependent-oxidoreductase
MKSFTVDRRNLLLAGGIGLLGVYVSKSLVFGETKGNRVVVLGGGYGGVTTAKYVKKLYPDAEVVLVEKNPMFVSCPLSNLYLVGLVPYEQLCYPYNNLVTKYGVNFVNDEVIGIELDKREVILGNGRLKYDYLVISLGIEYDYEENPALKEVYWSYPPAFRQGSEHLYLKRMLEGFEGESILISVPKMPYRCPSAPYERAALILSYAKKEGLKVHLYFVDENERPPVLTKGFLKAYQDFYKDDATYLTSTKVLEVDPVKKVARTTKGDIKFSMANFIPPMRAPKLLEKAGLLKKGEKWVKVDPMTFETSVKNVFVIGDSAFTYLPKSGYAAHSQGKVVAKVIASRLRKKPWEGELIQQAVCYAMVNLKQAIMMNVEYKYNLKTKEIKKEIYEDDTWKVSTAKRYIEWARGLWRDMFT
>NC_000918.1|WP_010880097.1|145594_146311_+|Rieske-2Fe-2S-domain-containing-protein
MDRRTFVKACGSVATLSLISSSFFTQTLRAQTNEFKKYKKAILLNKDGNPIKPEEIEVGKQYLFFYPYRSTPAFLLNLGKEVKPVEVKLLDGSSYLWPGGVGPQKSIIAFCAICPHQLSYPTPDYSFINYYPPDKPSKAAKKGNVIQCCAHMSIFDPEKGGVVLDGPAEYPLLTIVLSYEDGKLYAVGTLGVEKFSDFFDAYRSELKKMYKSFRKAKKKVDKSVVMRVEEYVNEVIYC
>NC_000918.1|WP_010880096.1|144274_145585_+|FAD-dependent-oxidoreductase
MGVNRRDVFKLAGLGVALGALQLPSIACAAKTSNSLLSPSKGKRIVIVGGGWAGVTAAKYIRKEIPDAEVVLIEQRKMFMSCPISNVWLGGLVDLEFLIHDFLTPAAKYGYTFINATVTDIDRDKRRVYTEDGYVEYDYLILAPGIRYNYDAWFNGDKDMARYAQTHYPSAFIPGSEHLRLKKKVENFEEGTFVLVVPPPPHRCPPAPYERAAMIAHVFRQNEAKAKLIILDPKEKIAPKGPGFRMAYEQLYLDIIEYVPNAKIKEVDPVKKVIKTTAGDFKFDDANLNPPHQAADIAWKAGLVNPKTGWCDVDPITLQSKVDKRIFIPGDANSVKGFPKSGDMANNQTKFMLVKAIKAMIEGKDPLEYVKAPTNTCYSMVNGDPKEAIVINVVYDIDKQKRMPVKKKVNVENERSQRLARATFEWAKAMYRDMFS
>NC_000918.1|WP_010880106.1|156793_157891_+|5-(carboxyamino)imidazole-ribonucleotide-synthase
MLTVGILGGGQLGWMTILEGRKLGFKFHVLEDKENAPACRVADRCFRTGQISEFVDSCDIITYEFEHIKDEVLEKCESKLIPNPQALYVKKSRIREKLFLKKHGFPVPEFLVIKRDEIIDALKSFKLPVVIKAEKLGYDGKGQYRIKKLEDANQVVKNHDKEESFIIEEFVKFEAEISCIGVRDREGKTYFYPQPFNKHEEGILIYNYVPYAKLKEAEEITKRLMELLDIVGVFTVEFFLLKDGRVLINEFAPRVHNTGHWTLDGAYTSQFENLLRAITEMPLGSTELKLPSGMVNILGKSYEEIPLKEILSVEGAKLYWYGKEKKPRRKVGHVNVVGRSKEEVVEKVERVFTLLKGSREKLPAP
>NC_000918.1|WP_010880107.1|157856_158696_-|DMT-family-transporter
MEYNHLLGITFSLFSAFFWATNDIFNKKLILKGYEENFVLWIRFPLGALLLLPFGLVYWDLNETVIKTTFLWLPSEILASIFFIKSLKYAPLSLAMPFYATMPAFSALAGWIVLGEVLSLRNWLGILLIVYGTTLLAGKNIKSFFTLNKGVLYALFSSFLFGVNVVIGKIAVVSSNQFFFSWYYCLVMSLALIPFVKRFEVKDFSSDWKFFGIVGLFFSLGMVFYTWAYIYTYASFVAATERLAILLDVLYGKVFFGEKVKNAFKASIIMVLGVFLLSL
>NC_000918.1|WP_010880108.1|158695_160132_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MLWKKSLSELRELLKRGEVSPKEVVESFYDRYNQTEEKVKAYITPLYGKALKQAESLKERELPLFGIPIAVKDNILVEGEKTTCASKILENFVAPYDATVIERLKKAGALIVGKTNLDEFAMGSSTEYSAFFPTKNPWDLERVPGGSSGGSAASVAVLSAPVSLGSDTGGSIRQPASFCGVIGIKPTYGRVSRYGLVAFASSLDQIGVFGRRTEDVALVLEVISGWDEKDSTSAKVPVPEWSEEVKKEVKGLKIGLPKEFFEYELQPQVKEAFENFIKELEKEGFEIKEVSLPHVKYSIPTYYIIAPSEASSNLARYDGVRYGYRAKEYKDIFEMYARTRDEGFGPEVKRRIMLGTFALSAGYYDAYYLKAQKVRRLITNDFLKAFEEVDVIASPTTPTLPFKFGERLENPIEMYLSDILTVPANLAGLPAISIPIAWKDGLPVGGQLIGKHWDETTLLQISYLWEQKFKHYEKIPLT
>NC_000918.1|WP_010880109.1|160144_160582_-|TraR/DksA-family-transcriptional-regulator
MNKELLEKCKQKLLEEKAKILERYLEKEETQQRLGEESKEPRDWEDIGQMTYTEELLDNLSNVEIATLREIDYALEKIEKGTYGICERCGEEIPEPRLCAIPWTRYCAKCAEEVERESGTYMPSYGVDMYNPENIQVEREDIGEA
>NC_000918.1|WP_010880110.1|160628_161309_-|N-glycosylase/DNA-lyase
MDAIQEVKRIIPEVQKYVNQRMEEFERLGREGWTHFDFRPFLDIDYDAGLFSELSFCILTANSSATLGIKIQAHLGEEGFLNKTKEELEEVFRKFGHRYAGQRAERIVEAREKFPKVKSLIEKEKNSKVIRELLADPKSPYKIKGFGYKEASHFLRNIGFKDLAIIDRHISRFLMEKGLLRQVKSITPKVYLEAEKALESLAKELGLSLGELDLYIFYIKTKKVLK
>NC_000918.1|WP_010880111.1|161324_161744_-|hypothetical-protein
MRFLILLLPFFLFAKEVCLDFSEIDTDDPYVKQAIIRKVEEYVLEAGFKVKCTENTLRIKVRANYREVPSTISARQRVSSYTLYLSVSLGEESFSASVPYSLPSGSLAELPRRKALEEAFSRIKLHIIKYFSREYLREK
>NC_000918.1|WP_010880112.1|161731_162217_-|pantetheine-phosphate-adenylyltransferase
MGKRVVYPGTFDPPHYGHLDIVKRSARIFDEVVVAVAKKPRKFLLFDAEERVKMFEKMVEDIPNVEVKMFDCLLVDFMKREGINVIVRGVRLFTDFEYELQIALTNYKLAGVETVFMMPSQEYIHISSTIVRDVASYCGDLDNMVHPYVKQKLREKFNCGS
>NC_000918.1|WP_010880113.1|162751_163159_+|S-adenosylmethionine-decarboxylase
MAKTLGLHILADLYGVDADKIDRVEDIRELLEGAVKYANLTKISSHYYQFQPHGATGVVLLAESHISIHTWPEHGLATVDVYTCGDPSKAYRAMDYIITQLNPKRIDKQVHERGIVEEESNQSEAEKLRSILLQV
>NC_000918.1|WP_010880114.1|163192_163678_+|hypothetical-protein
MKVLIVFYKDLEKNKEEILNLMKKNYKLIKRKLGIDNIYASITEEFLEIFYLFPEICLINNTRGTLNFGLYKGLRKLKGDDILVVDAGKSFSEGKFEKVPMGDLPSILMDKEKWAGLAYIPMREMYYFIRSLEENFDKCITEAFETLKKSYGINFVKSFIS
>NC_000918.1|WP_164930575.1|163681_164110_+|hypothetical-protein
MVDADILLIAFVDTIEGVKNLIGERGAGAVLRDAGRHSGPKLLESLIGKLPEEVDKDTALKRTAAILKELGFADEINYGNGKFIIKNDVFTEAVREDVNVQTPVVYFLAGLVEGFVQFMSNDKVVLKPVKAEKGYVEFEVSP

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Crispr_ID: NC_000918_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_000918_2

244561-244791

TypeIII

Consensus_repeat	Method
GTTCCTAATGTACCGT-GTGGAGTTGAAAC	PILER-CR
GTTTCAACTCCACACGGTACATTAGGAAC	CRISPRCasFinder
GTTTCAACTCCACACGGTACATTAGGAAC	CRT

3 spacers

DinG,cas2,cas1,cas4,cas3,cas8b2,cas5,cas7,csx3,csm6

The CRISPR arrays of NC_000918_2

>merge|NC_000918|2|244561-244791|PILER-CR,CRISPRCasFinder,CRT
GTTTCAACTCCACACGGTACATTAGGAACATGACATTTCAGGAGGTGGAGCATGATTACTATCTTTTCGTTTCAACTCCACACGGTACATTAGGAACAGTATAAGCTTTCTAAGCCTTGAAAGGAAAAGCTCCTCGCGTTTCAACTCCACACGGTACATTAGGAACTCTCTACCTTCCTTTCAACCTGTATTGCTATGTCCGGTTTCAACTCCACACGGTACATTAGGAAC

>NC_000918|2|2|244561-244791|PILER-CR
GTTTCAACTCCACACGGTACATTAGGAAC	ATGACATTTCAGGAGGTGGAGCATGATTACTATCTTTTC
GTTTCAACTCCACACGGTACATTAGGAAC	AGTATAAGCTTTCTAAGCCTTGAAAGGAAAAGCTCCTCGC
GTTTCAACTCCACACGGTACATTAGGAAC	TCTCTACCTTCCTTTCAACCTGTATTGCTATGTCCG
GTTTCAACTCCACACGGTACATTAGGAAC

>NC_000918|2|2|244561-244791|CRISPRCasFinder
GTTTCAACTCCACACGGTACATTAGGAAC	ATGACATTTCAGGAGGTGGAGCATGATTACTATCTTTTC
GTTTCAACTCCACACGGTACATTAGGAAC	AGTATAAGCTTTCTAAGCCTTGAAAGGAAAAGCTCCTCGC
GTTTCAACTCCACACGGTACATTAGGAAC	TCTCTACCTTCCTTTCAACCTGTATTGCTATGTCCG
GTTTCAACTCCACACGGTACATTAGGAAC

>NC_000918|2|2|244561-244791|CRT
GTTTCAACTCCACACGGTACATTAGGAAC	ATGACATTTCAGGAGGTGGAGCATGATTACTATCTTTTC
GTTTCAACTCCACACGGTACATTAGGAAC	AGTATAAGCTTTCTAAGCCTTGAAAGGAAAAGCTCCTCGC
GTTTCAACTCCACACGGTACATTAGGAAC	TCTCTACCTTCCTTTCAACCTGTATTGCTATGTCCG
GTTTCAACTCCACACGGTACATTAGGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_000918.1\|WP_164930591.1\|245059_245341_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_000918.1\|WP_164930589.1\|238346_238661_+\|GYD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378038
NC_000918.1\|WP_010880183.1\|236529_237600_+\|LptF/LptG-family-permease	unknown	unknown	gnl\|CDD\|367632
NC_000918.1\|WP_010880184.1\|237558_238302_-\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589
NC_000918.1\|WP_010880190.1\|245337_246288_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NC_000918.1\|WP_010880193.1\|248931_250527_-\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	cas8b2	cd09665_cas8b2_CAS-I-B	gnl\|CDD\|187796
NC_000918.1\|WP_010880185.1\|238637_239435_-\|glycosyltransferase-family-9-protein	unknown	unknown	gnl\|CDD\|340821
NC_000918.1\|WP_010880197.1\|253251_253587_-\|CRISPR-associated-protein-Csx3	csx3	cd09681_csx3_CAS-I:CAS-III	gnl\|CDD\|187812
NC_000918.1\|WP_164930834.1\|246791_248969_-\|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_000918.1\|WP_164930592.1\|246280_246808_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_000918.1\|WP_010880182.1\|234589_236518_+\|ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|224120
NC_000918.1\|WP_010880188.1\|240236_241949_-\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236405
NC_000918.1\|WP_010880195.1\|251157_252231_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	COG1857_cas7_CAS-I	gnl\|CDD\|224770
NC_000918.1\|WP_010880194.1\|250517_251177_-\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|273860
NC_000918.1\|WP_010880198.1\|253591_254953_-\|TIGR01897-family-CRISPR-associated-protein	csm6	COG1517_csm6_CAS-III-A	gnl\|CDD\|273862
NC_000918.1\|WP_164930590.1\|242212_244546_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|272984
NC_000918.1\|WP_165438797.1\|239434_239863_-\|copper-resistance-D-family-protein	unknown	unknown	gnl\|CDD\|224195
NC_000918.1\|WP_010880181.1\|234259_234526_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	unknown	unknown	gnl\|CDD\|225352
NC_000918.1\|WP_010880187.1\|239862_240240_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|129116
NC_000918.1\|WP_010880196.1\|252308_253250_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_000918.1\|WP_164930591.1\|245059_245341_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	4.11029e-26
NC_000918.1\|WP_164930589.1\|238346_238661_+\|GYD-domain-containing-protein	gnl\|CDD\|378038	pfam08734, GYD, GYD domain. This protein is found in a range of bacteria. It is usually less than 100 amino acids in length. The function of the protein is unknown. It may belong to the dimeric alpha/beta barrel superfamily.	8.45737e-31
NC_000918.1\|WP_010880183.1\|236529_237600_+\|LptF/LptG-family-permease	gnl\|CDD\|367632	pfam03739, YjgP_YjgQ, Predicted permease YjgP/YjgQ family. Members of this family are predicted integral membrane proteins of unknown function. They are about 350 amino acids long and contain about 6 transmembrane regions. They are predicted to be permeases although there is no verification of this.	7.26405e-14
NC_000918.1\|WP_010880184.1\|237558_238302_-\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	1.61653e-136
NC_000918.1\|WP_010880190.1\|245337_246288_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	1.7325e-169
NC_000918.1\|WP_010880193.1\|248931_250527_-\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	gnl\|CDD\|187796	cd09665, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	3.66475e-109
NC_000918.1\|WP_010880185.1\|238637_239435_-\|glycosyltransferase-family-9-protein	gnl\|CDD\|340821	cd03789, GT9_LPS_heptosyltransferase, lipopolysaccharide heptosyltransferase and similar proteins. Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	1.69551e-43
NC_000918.1\|WP_164930834.1\|246791_248969_-\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	6.37325e-142
NC_000918.1\|WP_164930592.1\|246280_246808_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.13696e-65
NC_000918.1\|WP_010880182.1\|234589_236518_+\|ATP-dependent-DNA-helicase	gnl\|CDD\|224120	COG1199, DinG, Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair].	4.63618e-118
NC_000918.1\|WP_010880188.1\|240236_241949_-\|proline--tRNA-ligase	gnl\|CDD\|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NC_000918.1\|WP_010880195.1\|251157_252231_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|224770	COG1857, COG1857, CRISPR system related protein [Defense mechanisms].	1.50876e-72
NC_000918.1\|WP_010880194.1\|250517_251177_-\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|273860	TIGR01895, conserved_hypothetical_protein, CRISPR-associated protein Cas5, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family is represented by TM1800 from Thermotoga maritima. It is related to TIGR01868 (CRISPR-associated protein, CT1976 family).	1.05336e-92
NC_000918.1\|WP_010880198.1\|253591_254953_-\|TIGR01897-family-CRISPR-associated-protein	gnl\|CDD\|273862	TIGR01897, hypothetical_protein, CRISPR-associated protein, MJ1666 family. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model describes a Cas protein about 400 residues in length, found mostly in the Archaea but also in Aquifex.	3.86138e-123
NC_000918.1\|WP_164930590.1\|242212_244546_+\|diguanylate-cyclase	gnl\|CDD\|272984	TIGR00254, Hypothetical_protein_yaiC., diguanylate cyclase (GGDEF) domain. The GGDEF domain is named for the motif GG[DE]EF shared by many proteins carrying the domain. There is evidence that the domain has diguanylate cyclase activity. Several proteins carrying this domain also carry domains with functions relating to environmental sensing. These include PleD, a response regulator protein involved in the swarmer-to-stalked cell transition in Caulobacter crescentus, and FixL, a heme-containing oxygen sensor protein. [Regulatory functions, Small molecule interactions, Signal transduction, Other].	1.77623e-79
NC_000918.1\|WP_165438797.1\|239434_239863_-\|copper-resistance-D-family-protein	gnl\|CDD\|224195	COG1276, PcoD, Putative copper export protein [Inorganic ion transport and metabolism].	1.31026e-28
NC_000918.1\|WP_010880181.1\|234259_234526_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	gnl\|CDD\|225352	COG2747, FlgM, Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion].	4.04781e-14
NC_000918.1\|WP_010880187.1\|239862_240240_-\|RidA-family-protein	gnl\|CDD\|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	3.27646e-58
NC_000918.1\|WP_010880197.1\|253251_253587_-\|CRISPR-associated-protein-Csx3	gnl\|CDD\|187812	cd09681, Csx3_III-U, CRISPR/Cas system-associated protein Csx3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small protein in some cases fused to Csx1 (COG1517) family domains.	1.42872e-46

>NC_000918.1|WP_164930590.1|242212_244546_+|diguanylate-cyclase
MEFLRAMEVSYSDTPLDVNIFRGEKVKALFGSIPEPEKSDEVVEAFKTKKKIFIEKDKVYKAVFPILARKECLKCHTNAKGGEVLGVIETRIDLSPIYDKLNKVLFLSLIFLLPLNGLLSFWASKHIIEVVKSFAKNLENNINRIRNLEDLKKISREMDVPYEELKHLYQSLYKLSEKVRQIAIDKDILELESRLLEKFIITSQLVNDWKEYIKALVNDINEVVNVDVVFSIFIENSFLDTEVFWLKEPTEDQKKVFEQSLEKEIISRLPISVVGNRTLVINHNVVRKNERFNNVSPDRFKIRTKTLLLDKPQLGGIVGIGIESELAEDPYKRAVLDSVLATLVNVIGSAKAISSYVNEIEFYAMRDPLTFLYNQRTFWELLNYELERANRFERSLSLLLLDLDNFKVINDTYGHAVGDRVLREVARIISEKKRKADVAARYGGDEFAVIVIGANSNQALNLARRLKDAIESLSIPVSESETVSPRVSIGIASYPEHALTSRDLFIIADSMLRKAKEEGRSKIRVPTIEDLQMSRVELTKKSMLVLDALNKRLIKPFFQPIVELKSGELFANEVLMRIGKENIPASEFIEAAENLGVIVRMDLILYEETLKKLVEEQYDKYVFMNLSSRALTSEDFLKNILRIVENSGFDPAKIVFELTERESVKNIDLVKRFLEELKEVGIKFAIDDFGSGYSSFHYLKKIPVDFVKIEGEFVKGALTDWRDKTFIESIVTLAKGMHIRTVAEFIENEEIKEIMKEIGVDYGQGYYFGKPSPKPWV
>NC_000918.1|WP_010880188.1|240236_241949_-|proline--tRNA-ligase
MRWSRYFLYTEKEEPKEAEAPSHRLLLKAGFIKQVSAGIYELLPPAYKVLKKVESIIRKEMDRSGAQELLLTVLNPKELWEETGRWETYGEELFKLKDRNGREYCLGPTHEEEITDLVRRVVRSYRQLPVILYQIQVKFRDEKRPRFGLIRAREFIMKDAYSFDTDDMSAMISYEAMKFAYQRIFNKLRLNVIMAEADVGQIGGKMSHEFIAFTDYGEAKVAYCENCGYAANAEIVPLPKPEEEKEEEKPMEKVHTPNVHTIEELSKFLDVHPSKIMKAVLYIVNEKEPVLVLIRGDREIDENKLEKVLGTDNFRLATDEEVQELLGTKKGFIGIFNLPENIKVLWDNSLYGVKNLVVALNEPDWHYINVNPGRDFQYGEFVDVAEVREGDPCPKCGSPLKVRRGLELGHIFLLGTRYSEPMKAYFTDRDGKEKPIIMGCYGIGVSRILAALVEQYHDDKGIKWPTPVAPFELDIILLNTKDEEMKNVAEKLYLEAEEKGIDVIFDDREESPGFKFADADLVGFPYRIVVGKKVKEGKVEVQSRHTGEKWDVEIEKAIDFVKEKIEEDKK
>NC_000918.1|WP_010880187.1|239862_240240_-|RidA-family-protein
MREIKTPKAPVPVGPYSQAVEVNGFLFISGQIGINPETGKLVEGFKEQVIQIFKNVDAILEEAGLKRENIVKVTIYITDIKKFKELNEIYEDYFKDVSVKPARVTVGVKELPLNAEVEIEIVAVK
>NC_000918.1|WP_165438797.1|239434_239863_-|copper-resistance-D-family-protein
MFMKELFLFLHVVLATFWVGGMLFLSLVVAPYLKDKPQIRNEAFQEVGKRFSLYGTFLSLFLLFVTGLVNTYLIQGGFRPSIHTKLGVFFVVVFISLLHDLWAGKKALYSEKHRVWAKWLGILNLILSLLLVYLGVRIRLGY
>NC_000918.1|WP_010880185.1|238637_239435_-|glycosyltransferase-family-9-protein
MKKALLYRRGGLGDTLLTFPILEILKRRGYETIAVGNTDYFSIAKEVGYADGVYSFIPEEEFDLKVIISFEGNVKPFPEKREWIVKHYLNSLGLGEEFSTKLPIKPVQDSPLKGKVVIHPSSGSKKKNPPLEVFLKLKDFLEERGKEVVFLLGEAEEHLREVLSPHFLSLSPLEIAKHLKTAGFYVGLDSGISHLASYLGVPSFIVYGPTDPLVWRPIGDKVFQISLNLDCSPCFPNVCEERMCLDTEEVLRKTKETLLRYWNSL
>NC_000918.1|WP_164930589.1|238346_238661_+|GYD-domain-containing-protein
MPMYVMLTKLSPYAVKDPKKLKEIEQKVKKLIEENCPGVKWVMNLVVFGPYDYLDVFEAKDDEEASKVALIIRSFGHATTETWSAMHWKDFKEVIDKLKGVPVA
>NC_000918.1|WP_010880184.1|237558_238302_-|triose-phosphate-isomerase
MRRLIAANWKMNKTVKETEEYINTFLKFVEHPESREILICPPFTSLYVAGKMLQGTGVKLGAQNCHYEKRGAFTGEISIPMLQEVGCEYVIVGHSERRHIFGESDELIHKKIVACLEMGIRPILCVGEKKEEREAGMTFKVIETQIKLALTGVEEHTDKIDIAYEPVWAIGTGTPATPEDAVEVHTFIRNLINQLNPKNEGKTRILYGGSVNPQNAKEFMKHEEINGLLVGTASLDPESFAKIVYSF
>NC_000918.1|WP_010880183.1|236529_237600_+|LptF/LptG-family-permease
MLLDRYLLSRFLGIFLNVSFVSVLLVSLYALLDFLVGFKEKRTDVALSYFLNILPLGFYYISFITLSISLILFLRKVFEKKMELTVQSFGISPLRFSLPVLLFSVFLSSTFLLGNEYAFPKLLGNLWFIEKNYKKKQEVKGFIKNFWFIKKENEVKTYYHVGNLNLSDGSLFNFYTMKVERKNLNPLEVLKVFSGVWKDKEIFIRSGEIYDFEKGKREKVFNKTFKLGLSIKEVELFSEKIDFLSLSEIFFLMQKSKKVGLNVDVYTGELFYRVMFSLSPVFISIFSLYLFFKHKVLSQVIPRFLVFIVILWLVILSPKILPQKANQPVLYSLIPIFLLILYSLKGVYDLRKGFRV
>NC_000918.1|WP_010880182.1|234589_236518_+|ATP-dependent-DNA-helicase
MDSISFYEYLLTKGFEERKSQREMIKIVEEALEEGGVKLIEAPTGTGKTFAYLIPIIVNKQKAIISTGTKILQDQLKRDIEFLAGHWKLLTGQKVNYAVIKGKGNYLCIDRFKKEEIPEADRLEVETFMETEWDGDLTLTGLASETIVKINVDDDYCTFAYRMACPFYRECYYWAKVKRREENADILVVNHSLLALKEFETKDKVLVIDEAHELDRYLTLATTFGISLYWFKDLQKSLEKLLGESVNIPAEEFFRNNFEKLFDEESNEAALESLREYIPQMKTLLYIPLNEAVEKLRKKVKEEVEKFVKETLMVSYTFKDFLENTLLFDRDLIDSVNAGYEEPTEREKELINKVKKIDYYRRKLNKLKAFIRTAEDEEEGVGYKVSRAWSKKLNGYNYRLEAFLIFPRNVIDPEEYKAVILTSATVEPEDIYLTTGITGEFYTLPHNYDYTTSTIFIEDTNPKKEDWKDKLTTNYYILRSEYDKVLVLLTNKEHLKLFEEDEEVGIQGKDSLTRLIEFLRSGRIKALIGLDSLWTGVDVKGEKGILMSKLPFENPRDPLTYHRLKFLEKVGEDPFTYQRRKAYIKFRQGVGRLIRQNSDKGKIVLCDNRIWRYREFVDFLRSLGINIVSKGKFKRKKRTPFW
>NC_000918.1|WP_010880181.1|234259_234526_+|flagellar-biosynthesis-anti-sigma-factor-FlgM
MVNRIELSRLIGLLLETEKRKNTEQKESGTNKIEDKVTLSKIAQELSKNDVEEKDLEKKVKELKEKIEKGEYEVSDEKVVKGLIEFFT
>NC_000918.1|WP_164930591.1|245059_245341_-|CRISPR-associated-endonuclease-Cas2
MKVILVYDVATDDKEGVKRLNKVRKIAKRYIHHVQKSVFEGEITLSRLERLKAELSDIIHKTKDSVIIYVFDDKTQYKREILTDTPDPTDNVI
>NC_000918.1|WP_010880190.1|245337_246288_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MGRVYYINSHGTLSRHENTLRFENAEVKKDIPVEDVEEIFVFAELSLNTKLLNFLASKGIPLHFFNYYGYYTGTFYPRESSVSGHLLIKQVEHYLDAQKRLYLAKSFVIGSILNLEYVYKISADTYLNKVKETNSIPELMSVEAEFRKLCYKKLEEVTGWELEKRTKRPPQNPLNALISFGNSLTYAKVLGEIYKTQLNPTVSYLHEPSTKRFSLSLDVAEVFKPIFVDNLIIRLIQENKIDKTHFSTELNMTFLNEIGRKVFLKAFNELLETTIFYPKLNRKVSHRTLIKLELYKLIKHLLEEEVYLPLNYGGLK
>NC_000918.1|WP_164930592.1|246280_246808_-|CRISPR-associated-protein-Cas4
MTISYEEITNLKFTGTQVAYYVICKRKLWLFSKGLSYESESEFVELGKLLDERAFKREKEEVEWGENPVKIDFLTGEEGLVVHEVKHSPKLEEAHVLQVKYYLWFLEKSGVKVSHGIIHYPKQRKVLRVELTQEDRKVIVEALENIQKVLLEEKPPEVIKKPYCKKCAYYEFCYG
>NC_000918.1|WP_164930834.1|246791_248969_-|CRISPR-associated-helicase-Cas3'
MRELLKKAWAKSDGTTIREHTDTLLKNLSILKNLFGEKIEEACPEDFRELLWKALELSCEYHDYGKLHCFFQKKVGNKNWKVLKGIPEVRHNLLSPAFVECEDENLKLLVQKVVLHHHEVPDQFEKAKEVLIKEFGFSEGKAKELDKLIGEEERFLERIALKKFKKRNSESLKKFYTLVKGLLLRIDHASSNKHLSEMEKGKLENPEKNVKDYLRKKGAQLNELQNYVLENREECLVVVAPTGYGKTEAGFIFLKDKGFFTLPFRVSANGIYERARAVFGENVGLLHSSSLIELMKKEEDELDTNTFEGIWKNYQHSKSFAYPLTVCTPDQIMPFVFKFSGYEKYLALLSYSRIVIDELQVYAPYTMAFIVKALEVIKDFGSKFMVMTATFPEFLRRFFEKMEIPFKEFPELKPRHNVKLLEDTLGSESSINLIRSLSEEGKVLVIVNTVRKAQELSLLLNAPVLHSRFLQKHRAKKEEEIKEFFSSGEKGVWVTTQLAEVSLDLDADFLVTELSTIDSLIQRMGRCNRKGIKDIENPNVYVFTQEPSGKGSVYPKELLELTRKALTEGIWEYDVKERAIKEVFGENIKKTKYYDQFKSALEYVEGFWRGSISLKESRHDAVQKFRDILSLNVIPYQFREEVLKVYKKWRESSDILERVLAFNELQSYTFSYPYSEKLLREGKIKKASELQELNVFWIKGDYDENLGFRISKEEDPEVIEDDNIL
>NC_000918.1|WP_010880193.1|248931_250527_-|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1
MGVKFYIDNWLTASSGVGLIEVLQDAEVEYKDLVKDSRKLELPEELFEKLPELYADFLTKGIDLTMKEQILKSKKLSIETLKNRLENPYTFINGYDIIKSFYRNSIFANNNPYKDIIKQENSKLLNSILNDIHRKEDMDYESIIDVLENKGYFENIRNVIKYYLIETLKLIISNQEDKNAPLCFFCRERHTYVYKGKYRVFGAEHFTPLSASEDTLPNLFWNGRNKMYLCPYCEFYLFFAAFGFTKVGNNRFLFVYIPDDLDSLISINSQLKSKEKVEKNILGELFRVVKFLRNVETQKARWILENIYFVEIEKVSEATANIYSFSISPRLAKVLKNYIDKYPPNFESVFPKFVEYVYSGRSLYEFLFKILSGFFFPKRYQNPKGYDADLIKKGMSFKEFLPKKLLYFIKFQEELIMGESFEKQINFAYREGLNLKKMYEKELGKEKAKDRIKTLSYRILEAVRRKDLDAFEQNLIRAYMQVEREIPYIFVQALKDENFNRIVYAFLIGLNGRDWSEGEPEGTSEESLGQE
>NC_000918.1|WP_010880194.1|250517_251177_-|type-I-B-CRISPR-associated-protein-Cas5
MECLKAEFFSPIALFKTPFSIKGIETYPLPPYSTVIGLLYTASGKKWKGERFNISVQGDYEAIFRDYVRFRKYNKKDKKLETLPLEVPLFYNFRLTVHILGDENLLKEFEKALKFPYVFPYLSGGEYPVKITKVKMVACRKEYFDTFNIPKNAYIPENIFTEEFRVSLEGHGVYYRVPSFLISQKPRQHEWVGVYYVQKGTKVSEMELLVDEEGEPVWV
>NC_000918.1|WP_010880195.1|251157_252231_-|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MAKALTLTIITSKASSLNYGETIGNVSVLKKVSLGDGSQITYVSDKALKYEIRRKGKEEKGWKLLDKLIKEYIQNEGRIVIKERESEEKKKKKKKIRVYDVDSLGIDLVKNFEEFDLFGGLFTKIIVNGKEVKKLKKDKISEEDIYYPEEYDSVKRTSPVKVTYAFSISKFQGDLDFMNNIDAYNRYIKHVGEAEEQRIVQTEQHTSHYYYTLTVDLDRVGVWEKEEGVEEVLSNEEKAKRVKDLLDIILTLSRQIKGRWENLSPVFVIGGVFSVKNPFFEDGILAKEVDNQLLLNVQRLKDCAELVPEGEEILCGIRSGVFANEEEIRQELNAKSVKEVFEELKKRVEEVYGVSKS
>NC_000918.1|WP_010880196.1|252308_253250_-|hypothetical-protein
MEGIKVLAKQFGKIKTPQGLAVAIALITAIAWFPDGLAGFLPSLKSNPFQAIIGAILTILGLSIIFFLHKKLRRGQKDSIIAEFGFIVLTLIFSLIVFNDFAITQFITSSLVFFSAWLHVREMEIVDYTVREVRPSNVKATVIFLSSAKYDEKFKKLMEKVEEIPTINDFFDFLEKEKMRLPWEMQLRLINEFSRSLKYVYVIGSVNSSSGSFEQIEDFKLIVNKFFPQIEVIKYREGLDFENLEKNFGVLKEIYSELKTKGLKEREIIIDTTGGQKIQSIAGALYSTAYDRFFAYVSTNSKSVKVFDVVPTE
>NC_000918.1|WP_010880197.1|253251_253587_-|CRISPR-associated-protein-Csx3
MNEILKTEDEVVRWSVKKINDDTTLIEFELKRDLVPEDLKKINPPDAVKNKFANTFIVLSGRGPIWLYGFLIHFYHPTKGIGVFDPRLGGAVVVSSHSPNKKVGDVIKWEG
>NC_000918.1|WP_010880198.1|253591_254953_-|TIGR01897-family-CRISPR-associated-protein
MKKVVIAPWGDPTNWQRVKYSYNDHEDKYPSATGIIIKAEKPDSVILVCPDSLAEKRIPYKEIKIQCSGNLSDKTQGNLPFENYEEIKSKVENKIKDFFSKNINFHKKPDVIISYSFGSYNTLEFEGQAEDFFAGVLKGLVYKFTEYLEKGIPEKIEIILDVSHGINYTTVMTYEAVRTLAQLLAYFTEVSLKVLNADPVIGRNIQKPLRINEIEYYSSIFPNLVVYRIKKEDKECEQILEAYDDSINEIGDNMKLEREHIFLSAIIHGTPLYILTYMPSSKDLKAKIDNAAGYYEKNIIIENEIGEKKIKVKRKLRFTENYITMLKAYFLSFILEKKGFSKKEEVLLEDINKLNEMIFREFPVLKHRISKETNNINERRDNIPEDFLIYREINRRGNRDFEERNFFAHAGFEYNSVMLKKDDKDIILKVNEQNKEKIENALKEAIQSLLLRR

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Crispr_ID: NC_000918_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_000918_3

263132-263291

TypeIII

Consensus_repeat	Method
GTTTCAACTCCACACGGTACATTAGGAAC	CRISPRCasFinder

2 spacers

cas10,cmr3gr5,cmr4gr7,cmr5gr11,cas6,cmr1gr7,cmr6gr7,csm6

The CRISPR arrays of NC_000918_3

>merge|NC_000918|3|263132-263291|CRISPRCasFinder
TTTTAACTCCACTACGGTACATTAGGAACCTGTTTAACTGCACCCGATATGCGTCCTAAGTCCTGTTTCAACTCCACACGGTACATTAGGAACTTATGAGGACGAAATCCCGGCGGACTACTTAGGAAGCGGTTTCAACTCCACACGGTACATTAGGAAC

>NC_000918|3|3|263132-263291|CRISPRCasFinder
TTTTAACTCCACTACGGTACATTAGGAAC	CTGTTTAACTGCACCCGATATGCGTCCTAAGTCCT
GTTTCAACTCCACACGGTACATTAGGAAC	TTATGAGGACGAAATCCCGGCGGACTACTTAGGAAGCG
GTTTCAACTCCACACGGTACATTAGGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_000918.1\|WP_010880201.1\|257018_257906_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl\|CDD\|224286
NC_000918.1\|WP_010880214.1\|269485_270304_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224035
NC_000918.1\|WP_024015099.1\|264846_265086_+\|sulfurtransferase-TusA	unknown	unknown	gnl\|CDD\|238180
NC_000918.1\|WP_010880210.1\|266218_266971_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|224072
NC_000918.1\|WP_164930835.1\|271125_272088_+\|disulfide-reductase	unknown	unknown	gnl\|CDD\|224959
NC_000918.1\|WP_010880207.1\|263584_264490_+\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_010880199.1\|254949_256071_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	gnl\|CDD\|224520
NC_000918.1\|WP_010880203.1\|258856_259258_-\|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	COG3337_cmr5gr11_CAS-III-B	gnl\|CDD\|225874
NC_000918.1\|WP_010880206.1\|261089_262955_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	gnl\|CDD\|274208
NC_000918.1\|WP_010880200.1\|256086_256986_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	COG1336_cmr4gr7_CAS-III-C	gnl\|CDD\|274210
NC_000918.1\|WP_010880209.1\|265666_266092_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|224955
NC_000918.1\|WP_164930594.1\|264486_264750_+\|flagellar-biosynthesis-protein-FlhB	unknown	unknown	gnl\|CDD\|376521
NC_000918.1\|WP_010880215.1\|270318_271080_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|224072
NC_000918.1\|WP_010880208.1\|265098_265647_+\|NADH-dehydrogenase	unknown	unknown	gnl\|CDD\|379334
NC_000918.1\|WP_010880213.1\|268430_269489_+\|CoB--CoM-heterodisulfide-reductase-iron-sulfur-subunit-A-family-protein	unknown	unknown	gnl\|CDD\|224070
NC_000918.1\|WP_010880204.1\|259247_260135_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	COG1336_cmr4gr7_CAS-III-C	gnl\|CDD\|224255
NC_000918.1\|WP_164930593.1\|258633_258834_-\|chromosome-segregation-protein-SMC	unknown	unknown	unknown
NC_000918.1\|WP_010880202.1\|257871_258615_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NC_000918.1\|WP_010880198.1\|253591_254953_-\|TIGR01897-family-CRISPR-associated-protein	csm6	COG1517_csm6_CAS-III-A	gnl\|CDD\|273862
NC_000918.1\|WP_010880205.1\|260131_261109_-\|type-III-B-CRISPR-module-associated-protein-Cmr3	cmr3gr5	COG1769_cmr3gr5_CAS-III-B	gnl\|CDD\|224683

Protein	Function_ID	Function_description	E-value
NC_000918.1\|WP_010880201.1\|257018_257906_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	gnl\|CDD\|224286	COG1367, COG1367, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	2.15017e-103
NC_000918.1\|WP_010880214.1\|269485_270304_+\|hypothetical-protein	gnl\|CDD\|224035	COG1110, COG1110, Reverse gyrase [DNA replication, recombination, and repair].	0.00836473
NC_000918.1\|WP_024015099.1\|264846_265086_+\|sulfurtransferase-TusA	gnl\|CDD\|238180	cd00291, SirA_YedF_YeeD, SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.	4.30464e-33
NC_000918.1\|WP_164930835.1\|271125_272088_+\|disulfide-reductase	gnl\|CDD\|224959	COG2048, HdrB, Heterodisulfide reductase, subunit B [Energy production and conversion].	7.77325e-121
NC_000918.1\|WP_010880199.1\|254949_256071_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl\|CDD\|224520	COG1604, COG1604, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	6.89564e-95
NC_000918.1\|WP_010880203.1\|258856_259258_-\|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl\|CDD\|225874	COG3337, COG3337, CRISPR system related protein [Defense mechanisms].	4.07712e-62
NC_000918.1\|WP_010880206.1\|261089_262955_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|274208	TIGR02577, thermophile-specific_DNA_repair_system, CRISPR-associated protein Cas10/Cmr2, subtype III-B. This model represent a Crm2 family of the CRISPR-associated RAMP module, a set of six genes recurring found together in prokaryotic genomes. This gene cluster is found only in species with CRISPR repeats, usually near the repeats themselves. Because most of the six (but not this family) contain RAMP domains, and because its appearance in a genome appears to depend on other CRISPR-associated Cas genes, the set is designated the CRISPR RAMP module. This protein, typified by TM1794 from Thermotoga maritima, is designated Crm2, for CRISPR RAMP Module protein 2.	2.11723e-131
NC_000918.1\|WP_010880200.1\|256086_256986_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	5.58564e-113
NC_000918.1\|WP_010880209.1\|265666_266092_+\|peroxiredoxin	gnl\|CDD\|224955	COG2044, COG2044, Predicted peroxiredoxins [General function prediction only].	1.15413e-35
NC_000918.1\|WP_164930594.1\|264486_264750_+\|flagellar-biosynthesis-protein-FlhB	gnl\|CDD\|376521	pfam01312, Bac_export_2, FlhB HrpN YscU SpaS Family. This family includes the following members: FlhB, HrpN, YscU, SpaS, HrcU SsaU and YopU. All of these proteins export peptides using the type III secretion system. The peptides exported are quite diverse.	6.99419e-27
NC_000918.1\|WP_010880215.1\|270318_271080_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|224072	COG1150, HdrC, Heterodisulfide reductase, subunit C [Energy production and conversion].	1.92393e-68
NC_000918.1\|WP_010880208.1\|265098_265647_+\|NADH-dehydrogenase	gnl\|CDD\|379334	pfam13686, DrsE_2, DsrE/DsrF/DrsH-like family. DsrE is a small soluble protein involved in intracellular sulfur reduction. The family also includes YrkE proteins.	1.66359e-56
NC_000918.1\|WP_010880213.1\|268430_269489_+\|CoB--CoM-heterodisulfide-reductase-iron-sulfur-subunit-A-family-protein	gnl\|CDD\|224070	COG1148, HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion].	8.26873e-139
NC_000918.1\|WP_010880204.1\|259247_260135_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl\|CDD\|224255	COG1336, COG1336, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.61086e-92
NC_000918.1\|WP_010880210.1\|266218_266971_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|224072	COG1150, HdrC, Heterodisulfide reductase, subunit C [Energy production and conversion].	1.07112e-69
NC_000918.1\|WP_010880202.1\|257871_258615_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.97239e-64
NC_000918.1\|WP_010880198.1\|253591_254953_-\|TIGR01897-family-CRISPR-associated-protein	gnl\|CDD\|273862	TIGR01897, hypothetical_protein, CRISPR-associated protein, MJ1666 family. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model describes a Cas protein about 400 residues in length, found mostly in the Archaea but also in Aquifex.	3.86138e-123
NC_000918.1\|WP_010880205.1\|260131_261109_-\|type-III-B-CRISPR-module-associated-protein-Cmr3	gnl\|CDD\|224683	COG1769, COG1769, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.64749e-146

>NC_000918.1|WP_010880206.1|261089_262955_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MKLLVFTFSPVQGFIEKSRKLRDFFNSSLILSYITKKLIEKLKEDPDVEIIYPAIKEHDSEKLLMNYPNRLVAKFEKDKNYCEELKNQFSKIWEEIYTYIADKIKIPESVKATFKSHNKHYFTYFCEIQEEVDREEWMTELKVNEETLKKFKINQENPYGFTYDLLERKLGARKTFRPYYGRVDENKKVHGCTLCGERPALDLNWEELRKNLPPYHLDDSERLCGVCLTKRFFHFYLKEKEGIKDLAKFHSTRHFALAPLIKKVEKDKLSEEEKEILREILSMYTNNQINDGNLKELIYNNIDELTYKRVKALVRKRLDKIPDKDKEVRLKEFEKKFKNSYFSILMADGDEMGKWLGLKPEKRKVELTENFHKKFSEALFKFAQKITKIEDNICLKFVYLGGDDVLAVAHPSVILKAAKIIRKRFSEILKKELKPSNIKEDPTMSAGLVIAHEKENLAFVLEHLRTAERRAKNEGRNRLCISVIPHNSYPRELVLKWDNLENFIKLIEYFKSEKLSSRIPYYLRKELEIFIINEESVVNMKDIALSVIKRILKRQISKNQNDKKLNEYEYYSLITQIEDLINERIKETGSLKNALEYVLNTFYIARFIANMEGLKHENIPV
>NC_000918.1|WP_010880205.1|260131_261109_-|type-III-B-CRISPR-module-associated-protein-Cmr3
MKIYLFKPYDVIGFGGLKNFSAGETHIQKSIFPPPIMRFFHIFNSVYGVFLYKDGNLFLPVPSDCLVKRKEESGKAKISPLEFPPLIRGDLEAYERANGFISFSDLMNKYAKNIDGFKIYLLEEFLKKESRVGITLDKERRVVRSIKEINRKEEKGLLYSQDFFRFNDGVKLAVLGEINKDIVISGKQYFRLGGEGKIVSFKHTEHINSFLEGKIKIKNGNYYKFYCLTHAYINNGIIESKIQTICIEGINFEVEWLYNGGVEYVSGYNKPFLEMLRPGSVLILKAKNEGEIQRLNQISTNVPISNIKNFLNRGWNSGIIVEGVK
>NC_000918.1|WP_010880204.1|259247_260135_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MRRETYFIKAITPLHIGTGQGLTHIDLPIAREVHTGFPFIPGSAIKGCLREYHIKKVARNTELTASMIDEILQEGEIRGNLNDKEKKYLKMLIDIFGTAGEGSEESSASAGKVIFTDARLFLFPVRSTNGVFQLVTCPYVINRYLEDTGEKECFCLDLPDDTAVVYFDRYPNIDEVMLEEFTLRKQRNKKFEEIISRIPLESYQKERVLCVSDSVFSYMVKNYTEIQTHIKINRDSGTVESGALWTEEYLPAESVLYFNLFYEKQNLNLEVPEFFHLGGDITTGKGLVRRLGNAN
>NC_000918.1|WP_010880203.1|258856_259258_-|type-III-B-CRISPR-module-associated-protein-Cmr5
MQTRIQKVVKFAYGCVNEVKGREQIEEKYASYVRKLPSMIIHNGLLPTVAFIRSKAGIDAQNKLSPEKEAWKKIENHIKNYLIKIENVEVPDSLTRLFAEMDFSRYRLYTQKILFFTQWLKRVAEGELKSEEE
>NC_000918.1|WP_164930593.1|258633_258834_-|chromosome-segregation-protein-SMC
MSRKRKAGRKKKQEFVRTTISLPKDLWEELRIESVKKKTPLGKLIAQKIELLKKLQKKYSVQEEDI
>NC_000918.1|WP_010880202.1|257871_258615_-|CRISPR-associated-endoribonuclease-Cas6
MRFLIKMENLKEEPAKVRLDYRSRFISLLKSVLGEEYYSNHKIKPFTFAVFFGKEAKISNGYIENVRTINFRFSSGDFLTIAKFYNGILQLKKNQYIHPIGTGKFKIIDFRPEKEREIIGFFKTLSPIVIERIGSKPKDSPEERYITPDEESFEESLVENIYRRYIAIMGSEPQFSKFKFIPVKVKKEYVRHYGGIVKTFIGKFKIETDSKDLLEFIYKYGLGVRTGQGFGYLEVEDEKRTSKNINI
>NC_000918.1|WP_010880201.1|257018_257906_-|type-III-B-CRISPR-module-RAMP-protein-Cmr1
MKKEHQKTLTFEIITPVVMAGTYKDEPELRIPSIKGMLRWWFRFFYASHNQSIDKLREHENEIFGSTEKACQFYMHLKYSQKLTDAYLAMNKRYGRYNNIKRKALEKNDTFRIDFIYSPFFTYKKELNTTLQLLSFLGGIGARWRRGFGSIQLKNGEDYKSFDKLKEKIEKVLKGKGEYHHDGFININNVDIYLVKPKRDNFWIDSLGAMNNLRKKVYKEFKSETNIKAIACKPKGGSRAVSPLIIQIKKFSEGKFYGILIVYNEWDKYEEFKNFINNNSELSFEQLLKSKPRKI
>NC_000918.1|WP_010880200.1|256086_256986_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MYEYGQLLTLYAVTPIHIGSGQSISFIDLPIQRERHTGFPILRSNGIKGALRSVAERVWKDKAKVETVFGPEDDASKFAGCVSITDARILFYPVRSVRGVFAWITSPIVLRRFQEDLRSIGKEINIKVLKNGKEVPSNLNLEENEAILFSDGLIKDGKLFLEEFAFNPILNAPENVDWDFFNTIIPSDELVGLLRTHLVIVSDNVFRDLVNYAVEVRTRIRINQATGTVERGALFTEEFIPSESIFYSLLNISEPHNKEVFEKAEKVREEVKDLINRCKIIQVGGDESLGKGFIRLNLC
>NC_000918.1|WP_010880199.1|254949_256071_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MANTIVVGELIFGTGYFSTGKLEVGKEKGKETDNKKNFIHKALKKVDFLEEFESLNLLLNKYIPIPCGDIVTIKNNNEKLWLKDGTINEELKKIFLEEIIKDDNFGKLKEKLKNFSEILKRKNREIAQSLLNQGYVNVFNEDEFLKLKTAERLIVGLGTTHVFETGLALHHLFGIPYIPSSSLKGIVRMAHFWEIVEENIKNIKEDKKDDVIKRLQEKLQKGDIRKEQNKEFLIHMLLFGTQKFKGLLTFLDAYPMIDESNKNKIFDLDLINVHYKSYYTQNKPPGDWENPNPVYFLTVSKGIEFHFWVLFDSYRAEKLKKYNDFENVINELLDNNYENLRNKLKELLEDTLTLYGVGAKTRLDYGIFDGGNK
>NC_000918.1|WP_010880198.1|253591_254953_-|TIGR01897-family-CRISPR-associated-protein
MKKVVIAPWGDPTNWQRVKYSYNDHEDKYPSATGIIIKAEKPDSVILVCPDSLAEKRIPYKEIKIQCSGNLSDKTQGNLPFENYEEIKSKVENKIKDFFSKNINFHKKPDVIISYSFGSYNTLEFEGQAEDFFAGVLKGLVYKFTEYLEKGIPEKIEIILDVSHGINYTTVMTYEAVRTLAQLLAYFTEVSLKVLNADPVIGRNIQKPLRINEIEYYSSIFPNLVVYRIKKEDKECEQILEAYDDSINEIGDNMKLEREHIFLSAIIHGTPLYILTYMPSSKDLKAKIDNAAGYYEKNIIIENEIGEKKIKVKRKLRFTENYITMLKAYFLSFILEKKGFSKKEEVLLEDINKLNEMIFREFPVLKHRISKETNNINERRDNIPEDFLIYREINRRGNRDFEERNFFAHAGFEYNSVMLKKDDKDIILKVNEQNKEKIENALKEAIQSLLLRR
>NC_000918.1|WP_010880207.1|263584_264490_+|hypothetical-protein
MELRRIEGILLEQSLLSSKGQEVVKTARNLEIKITSQIPEVYKTLLNLTKVKAKVLRNRGNVITLLLDNGIEINAKNEMSVSLREGQSVVLTLVRENPLTFKLEEGKFVKNTTLEVLRKGLKNLKKFDFSQIENYENFKNSGIFYENKVLKAIIKNSIDDLKVDLKYKALIKQDKEILEFINFLQMYALENPRSILLPFKLQDFEGFLSIKVKEFYEVFVHINTEKYSLNISFFVEKNLNFSEVEISSNSEEVLQRLESLKDDIRKIFNVPIRSFNFLLKENVKEEVLREILKEGGLDLKV
>NC_000918.1|WP_164930594.1|264486_264750_+|flagellar-biosynthesis-protein-FlhB
MNDEVKKAVALKYNPEEDRAPVIVAKGRGEVAEKIIKIAKEKGIPITEDENLVEALIKIDLYEEIPPELYEAVAKVIAFVTLKLKGL
>NC_000918.1|WP_024015099.1|264846_265086_+|sulfurtransferase-TusA
MATITPDKVLDTSGLNCPLPVLKTKKALEELQPGQILEVISTDPGSKADIPAFCQRTGHELVEMTEEGGKYIYYIRKKG
>NC_000918.1|WP_010880208.1|265098_265647_+|NADH-dehydrogenase
MPTERLAIIATKGTLDMAYPPLILASVAASLGVETAVFFTFYGLNIIHKEKVKQLKLAPIGNPAMPMVFPDSVKQTPVVGQLAGLMESIFPGPPQIMGIIPGMTNFMTAMMKKRLKEKGVASIEELLELCKEADVKLIPCQMTMDLFGYKREDLIDGLEPPAGATEFFNYVLAADKPMIIFV
>NC_000918.1|WP_010880209.1|265666_266092_+|peroxiredoxin
MAGQEFEKLLFYIVTVPFFVRAEPTTGELINPQAGAPFFLATAATTMDYEVEMVITSEAGYLLMRDNAKKVKVRPGVEQTVYDFIKMAKDAGVKIYLCTPSLDLTDIYKEEDVNKEICDGILGGAAFLDKLMSGEYAVITL
>NC_000918.1|WP_010880210.1|266218_266971_+|4Fe-4S-dicluster-domain-containing-protein
MAEQTQVRKYGYNIPISEKTLQVPWEEKVRVIEEVKSDFRFKEYLFGCLNCGVCTASCPSNRFFDYSPREIVQRFLENDIDVLYDMMHEYIWACSQCFTCWIRCPFVNNPGGLVIIMREVAVRNAFEATKDLLKPYGRVLLKVMTTGNQLSADMLQPDFFPDWGPKMLDNMENLRPKRMAIPFDVGKSVKTAWEVSLQTAIEMYQIWRDTGIFEMLERLDPNLYNVIMDIVEENEERWEELMEEMEEAEA
>NC_000918.1|WP_010880213.1|268430_269489_+|CoB--CoM-heterodisulfide-reductase-iron-sulfur-subunit-A-family-protein
MAKSVLVIGGGPAGLAAARTLGKLGIPTILVEKEGKLGGRPILEEYHTLIPRKMKPQQVLGPFIEEVQNNPNIEVKLNTEIEACEGEAPNFKVKLSNGETVEVGAIVVATGFQHFDAKRKGELGYGIYPDVITNLELEQMFSREGKLYRPSNGELPKRVAFVFCVGSRDRQLGVTNVHCCRYGCALSGLQGSEIREKYPEVEVFCYYMDVRTYGTWEYPFYWEPQEKYGVRYVRGRIAEITYSPKDGRLRVKHEDTIVQRPAEIPMDLVVLVLGMEPSEGTKKVAKILGLAQDPDSQFLIPAEDSGSNIISNRPGVFIAGACKGPIDIESSLAEGEAAGAEAATFLGAKVSV
>NC_000918.1|WP_010880214.1|269485_270304_+|hypothetical-protein
MSERQNTGGFKAASLDEALIRDYLIKILSEGEEFLQDFYQDVKAKSEFFQKKLSKDNIKKLTEKDLEEILDKIFAARRKKKRIIEETGVENLKEAIKKLLYGEEGGFLGLGKKEDKRTWEEKVEEFARSIRGVDKRAAKDIAAELLHFTFPDKYILWTSWVWDPETETGAIVFLKEEPPTGGKGRKMYGETYEQFEQVYKQIMEKLHEFGVKVKDYLFVDIFLAMIYATYVDYMTLSTMHSAKGFFPPAGVMARRLLGVHAPIRYTDVEEVS
>NC_000918.1|WP_010880215.1|270318_271080_+|4Fe-4S-dicluster-domain-containing-protein
MAIHERSLVEPERILRKDRLVIDGIDVSGDWNLIILPRTIEDYDLSLLDEILQQPEGKTILQCYQCSYCTASCPVHNYWDERYNPRHFIYLARLGLVDELQKRADVMWRCVSCHKCTHRCPKGVLVEEVLKAILKVLSKRGLIEEYPSKKFDKFFLEQVYEYGRIEDGDLLFGWIEKQGYKVFKDPILKKPIPLFGEIPEWLKTLAIKPIKNMNIDFLILNAKHMLIHPRTKNWSKMKQVLKKVFEEEGVTLH
>NC_000918.1|WP_164930835.1|271125_272088_+|disulfide-reductase
MGGIGKKVAYYPGCSLEGAARAYDVSTRIVAKELGLELDYLEDYNCCGAMETKNVSFWGTMLLNARNMSLARRQGHNVIVAPCNGCSFSLQRVEYFLETDKNTLDRINQLLQEAGEKPLDNIPHTYHILEWFYHEAGPEKVKEKTKKPLRGLKVASYYGCLYTRPHFYARTYSHLAPEDEEQARPRKRETADDDEHPYYMEALLEAAGATSVEIEPMHTQCCGGPHSLSDEEVSEKFVMMILQTAKRNGADIIATECPLCHASLEMYRHRLMLKGVPDVDVPAAYFTQLLGLAFGYSVNDVKLKDNLSDPIPVLKRLGLA

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Crispr_ID: NC_000918_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_000918_4

279264-279555

TypeIII

Consensus_repeat	Method
GTTTCTAATGTACCGT-GTGGAGTTAAAAC	PILER-CR
GTTTTAACTCCACACGGTACATTAGAAAC	CRISPRCasFinder
GTTTTAACTCCACACGGTACATTAGAAAC	CRT

4 spacers

The CRISPR arrays of NC_000918_4

>merge|NC_000918|4|279264-279555|PILER-CR,CRISPRCasFinder,CRT
GTTTTAACTCCACACGGTACATTAGAAACCATCTGCAACATATTCAAGTTCAGCTTCAAAACCTTGTTTTAACTCCACACGGTACATTAGAAACTTCGTCAAGCTTTACCTCAAAAGTCCTCTCAAACCTGTTTTAACTCCACACGGTACATTAGAAACAATAATCAACAACTCTTTGATTTTGTGAAATGGAAGAAGTTTTAACTCCACACGGTACATTAGAAACAGAACTCTCAGAAGAACCGAGAGCTTTTTCTATTAACGTTTTAACTCCACACGGTACATTAGAAAC

>NC_000918|4|3|279264-279555|PILER-CR
GTTTTAACTCCACACGGTACATTAGAAAC	CATCTGCAACATATTCAAGTTCAGCTTCAAAACCTT
GTTTTAACTCCACACGGTACATTAGAAAC	TTCGTCAAGCTTTACCTCAAAAGTCCTCTCAAACCT
GTTTTAACTCCACACGGTACATTAGAAAC	AATAATCAACAACTCTTTGATTTTGTGAAATGGAAGAA
GTTTTAACTCCACACGGTACATTAGAAAC	AGAACTCTCAGAAGAACCGAGAGCTTTTTCTATTAAC
GTTTTAACTCCACACGGTACATTAGAAAC

>NC_000918|4|4|279264-279555|CRISPRCasFinder
GTTTTAACTCCACACGGTACATTAGAAAC	CATCTGCAACATATTCAAGTTCAGCTTCAAAACCTT
GTTTTAACTCCACACGGTACATTAGAAAC	TTCGTCAAGCTTTACCTCAAAAGTCCTCTCAAACCT
GTTTTAACTCCACACGGTACATTAGAAAC	AATAATCAACAACTCTTTGATTTTGTGAAATGGAAGAA
GTTTTAACTCCACACGGTACATTAGAAAC	AGAACTCTCAGAAGAACCGAGAGCTTTTTCTATTAAC
GTTTTAACTCCACACGGTACATTAGAAAC

>NC_000918|4|3|279264-279555|CRT
GTTTTAACTCCACACGGTACATTAGAAAC	CATCTGCAACATATTCAAGTTCAGCTTCAAAACCTT
GTTTTAACTCCACACGGTACATTAGAAAC	TTCGTCAAGCTTTACCTCAAAAGTCCTCTCAAACCT
GTTTTAACTCCACACGGTACATTAGAAAC	AATAATCAACAACTCTTTGATTTTGTGAAATGGAAGAA
GTTTTAACTCCACACGGTACATTAGAAAC	AGAACTCTCAGAAGAACCGAGAGCTTTTTCTATTAAC
GTTTTAACTCCACACGGTACATTAGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_000918.1\|WP_010880233.1\|287856_288189_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_000918.1\|WP_010880225.1\|278110_279226_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237139
NC_000918.1\|WP_010880226.1\|279845_282320_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223690
NC_000918.1\|WP_010880217.1\|272162_272570_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224955
NC_000918.1\|WP_164930835.1\|271125_272088_+\|disulfide-reductase	unknown	unknown	gnl\|CDD\|224959
NC_000918.1\|WP_010880232.1\|287455_287857_-\|type-II-secretion-system-major-pseudopilin-GspG	unknown	unknown	gnl\|CDD\|130771
NC_000918.1\|WP_010880234.1\|288188_288536_-\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_010880220.1\|274128_275271_+\|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	unknown	unknown	gnl\|CDD\|223814
NC_000918.1\|WP_010880224.1\|277238_278114_-\|aspartate-carbamoyltransferase-catalytic-subunit	unknown	unknown	gnl\|CDD\|223614
NC_000918.1\|WP_010880223.1\|276723_277248_-\|DUF4416-family-protein	unknown	unknown	gnl\|CDD\|379590
NC_000918.1\|WP_010880222.1\|276096_276708_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223566
NC_000918.1\|WP_010880218.1\|272597_273044_+\|glycine-cleavage-system-protein-H	unknown	unknown	gnl\|CDD\|237370
NC_000918.1\|WP_165438798.1\|285503_286553_+\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	unknown	unknown	gnl\|CDD\|184693
NC_000918.1\|WP_164930837.1\|275230_276094_-\|UPF0104-family-protein	unknown	unknown	gnl\|CDD\|223469
NC_000918.1\|WP_010880231.1\|286549_287209_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_000918.1\|WP_010880228.1\|283035_284355_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|225935
NC_000918.1\|WP_010880227.1\|282322_283039_+\|LPS-export-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224060
NC_000918.1\|WP_164930595.1\|284344_285490_+\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|273348
NC_000918.1\|WP_164930596.1\|287195_287459_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|225076
NC_000918.1\|WP_010880219.1\|273086_274112_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|224769

Protein	Function_ID	Function_description	E-value
NC_000918.1\|WP_010880233.1\|287856_288189_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	3.77051e-08
NC_000918.1\|WP_010880225.1\|278110_279226_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NC_000918.1\|WP_010880226.1\|279845_282320_+\|CBS-domain-containing-protein	gnl\|CDD\|223690	COG0617, PcnB, tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis].	4.60343e-71
NC_000918.1\|WP_010880217.1\|272162_272570_+\|hypothetical-protein	gnl\|CDD\|224955	COG2044, COG2044, Predicted peroxiredoxins [General function prediction only].	1.80886e-41
NC_000918.1\|WP_164930835.1\|271125_272088_+\|disulfide-reductase	gnl\|CDD\|224959	COG2048, HdrB, Heterodisulfide reductase, subunit B [Energy production and conversion].	7.77325e-121
NC_000918.1\|WP_010880232.1\|287455_287857_-\|type-II-secretion-system-major-pseudopilin-GspG	gnl\|CDD\|130771	TIGR01710, Type_II_secretion_system_protein_G, type II secretion system protein G. This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	5.80344e-70
NC_000918.1\|WP_010880220.1\|274128_275271_+\|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	gnl\|CDD\|223814	COG0743, Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism].	0
NC_000918.1\|WP_010880224.1\|277238_278114_-\|aspartate-carbamoyltransferase-catalytic-subunit	gnl\|CDD\|223614	COG0540, PyrB, Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism].	2.38743e-126
NC_000918.1\|WP_010880223.1\|276723_277248_-\|DUF4416-family-protein	gnl\|CDD\|379590	pfam14385, DUF4416, Domain of unknown function (DUF4416). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 176 and 187 amino acids in length. There is a conserved DPG sequence motif.	1.34635e-66
NC_000918.1\|WP_010880222.1\|276096_276708_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	2.64077e-37
NC_000918.1\|WP_010880218.1\|272597_273044_+\|glycine-cleavage-system-protein-H	gnl\|CDD\|237370	PRK13380, PRK13380, glycine cleavage system protein H; Provisional.	8.20114e-68
NC_000918.1\|WP_165438798.1\|285503_286553_+\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	gnl\|CDD\|184693	PRK14467, PRK14467, 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN.	0
NC_000918.1\|WP_164930837.1\|275230_276094_-\|UPF0104-family-protein	gnl\|CDD\|223469	COG0392, COG0392, Predicted integral membrane protein [Function unknown].	1.47419e-12
NC_000918.1\|WP_010880231.1\|286549_287209_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.89519e-102
NC_000918.1\|WP_010880228.1\|283035_284355_+\|universal-stress-protein	gnl\|CDD\|225935	COG3400, COG3400, Uncharacterized protein conserved in bacteria [Function unknown].	0
NC_000918.1\|WP_010880227.1\|282322_283039_+\|LPS-export-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224060	COG1137, YhbG, ABC-type (unclassified) transport system, ATPase component [General function prediction only].	4.40141e-136
NC_000918.1\|WP_164930595.1\|284344_285490_+\|sodium:proton-antiporter	gnl\|CDD\|273348	TIGR00932, Na+/H+_antiporter, transporter, monovalent cation:proton antiporter-2 (CPA2) family. [Transport and binding proteins, Cations and iron carrying compounds].	2.53057e-64
NC_000918.1\|WP_164930596.1\|287195_287459_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	7.40346e-07
NC_000918.1\|WP_010880219.1\|273086_274112_+\|radical-SAM-protein	gnl\|CDD\|224769	COG1856, COG1856, Uncharacterized homolog of biotin synthetase [Function unknown].	1.06385e-145

>NC_000918.1|WP_010880225.1|278110_279226_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MRKTAILALEDGSYFVGYSFGAEGETGGELVFNTSMTGYQEILTDPSYKGQIVVMTYTQIGNYGVNDEDIESKSVQVNGFVVKEAFFRYSNWRAKKSLDEYLKENNVVGIYGIDTRALVKKIREKGSMKGVISTVEKDPKKLVQKARELPDISEQNLVEEVSAKDIYYWNQGDYDPRRGFLYRENEKPLVAVIDFGVKFNILRRLVSEGAKVVVVPPENAKEAIEKINPDAIFLSNGPGDPERVISGIRLTREYMEKKPIMGICLGCQIIGLALGGKTYKLKFGHHGGNHPVKDLRTGKIEITAQNHNFAIDPESLPEDVEVTHLNLLDNTVEGIKHKHLPIFAVQYHPENSPGPHDSYYLFKEFVKMAQG
>NC_000918.1|WP_010880224.1|277238_278114_-|aspartate-carbamoyltransferase-catalytic-subunit
MRSLISSLDLTREEVEEILKYAKEFKEGKEETIKASAVLFFSEPSTRTRLSFEKAARELGIETYLVSGSESSTVKGESFFDTLKTFEGLGFDYVVFRVPFVFFPYKEIVKSLNLRLVNAGDGTHQHPSQGLIDFFTIKEHFGEVKDLRVLYVGDIKHSRVFRSGAPLLNMFGAKIGVCGPKTLIPRDVEVFKVDVFDDVDKGIDWADVVIWLRLQKERQKENYIPSESSYFKQFGLTKERFEKVKLYMHPGPVNRNVDIDHELVYTEKSLIQEQVKNGIPVRKAIYKFLWT
>NC_000918.1|WP_010880223.1|276723_277248_-|DUF4416-family-protein
MDLAKFIFSILFNKNKRDKLDQALKRIEKEFGEIEEVSKEFYFPFLENYYGREMGKPLKKIYLSLKGLKNKEELVEVKLKAMELEEELSEEGKRSVNLDPGYLDESQLILASHKRRGARVYLGSGIYAEIELLFVYRDFRPIYWTYRDYRHPEVREFFRRVRKRFLKERKAFSG
>NC_000918.1|WP_010880222.1|276096_276708_-|NAD(P)/FAD-dependent-oxidoreductase
MRYDVVIVGGGPAGLACALTLASSQGRGWEWAEGKKFLVIDNGRSDLNKAMLNNVPGIPMGTLGPELLEKIREQIKATNDSVEFLEDTVTKVEGEKGNFKVHTQSGKVFEAEYVVLASGFHKFEIECEGVEVVDNPKSPKPGRVMVKHDGDYKVREGLFVAGLLAGVSSMYTAAAGSGVQVAINILSEWAGKPIVIHDVPKEK
>NC_000918.1|WP_164930837.1|275230_276094_-|UPF0104-family-protein
MFLSLFISLLFLSLIFYFLPLNELLISLKSIKTETLILSFLLYSLSQFTRSVRWSLLLSLPLKESFFLNSANLFLNNVLPARSGELSWFYYAKKLGINFKYSLWSFTIGRLYDLLALIFVVFISYLLAKEGTFFALLGLFVGFFLALLIPFLVNLIPEIWKLTDLKNFLRRELSVKLSLYLFTLSGISFFLKALSTYILVESLVRLNLFEYTLGFLGGELSSILPLHSFMGYGTYEAGFLLPLKLLGLEVKEGLKIGFIVHNFLLLSSAFWGVLSILYLHTFSRKSP
>NC_000918.1|WP_010880220.1|274128_275271_+|1-deoxy-D-xylulose-5-phosphate-reductoisomerase
MKLGVLGSTGSVGSQTLQVYENFRDEIELVGILANRASEKLLQQAKKYKPKYVVSYQEPAKEWLESLPEGVKYLKGDEGLKAIIEESERLMNAISGIYGIKPAYEVIKAGKTLLASNKESILCLGEIIRKNRERVIPVDSEHNALFQLLSSVKREEVKHVYLTASGGPFKDKSLEELKTASVEEALRHPRWNMGAKITIDSATLMNKGFEMLEAHFLFDFPIENIKVVIHPQSFVHGILELIDNSFLMHTSQTDMKIPIMHALFYPKRKEYPFKKVSLLELSPITFEKVDTTKFKAIDLAKWAGFMGGVYIPVLVGADEEAVNLFLNKKIGFLDIVDLIEQALSEVNIKDPQSVEEILEAVEWGRQKVREIYERKYAGKG
>NC_000918.1|WP_010880219.1|273086_274112_+|radical-SAM-protein
MNVFGVIQELDVELNEKLVEKLIEGFEIRKKNFGDKVFFYSPGFKHYEVEDFSVNSPPKFVDISVTGRNCELMCDHCASKILWHMIPATTPEELVKVGEDLKKKGIEGVLISGGSDKNGFVPLWDFFDAMKYLKEELGFLLTCHVGLVDEDYVEKLKEANVDAVLLDIIGDNETIAQVYKLPHKSVEDYDRSLRLLKEAGLRIVPHVIIGLHYGKIKGEYNAIDMIAKYEPDALVLVVVMPYYGKAKFQLLPPPSSEESAQVILYARKAVPNSPVVIGCARPAGADRVKLDAYSVLAGVNGIAFPAEGIVTYSKSLGLEPVVSPNCCSTVYSMVFQTMETQ
>NC_000918.1|WP_010880218.1|272597_273044_+|glycine-cleavage-system-protein-H
MAEVNGCQLPEDRLYYINPDKNAFIWAKEEDGVFTIGLTSVAAAMAGRLVAYTPKKVGKAVKKDKSVATIESGKWVGPVPSPFDGEIVEVNEALKGNPALVNDDPYGQGWIAKVKPANPEEAKSVLVDANKAAELLQPIVQEKGVKCG
>NC_000918.1|WP_010880217.1|272162_272570_+|hypothetical-protein
MLEKELKIVILMTSGPKTPWRCATPFYIATLMAAQEADVEIFFNMDGTNLIKKGVAEKICPSLEGNCFSANGQKPKTVYDFMKDAKLAGVKFYSCKQAVDSMGLTEEDLIPELDGIVPASEFALRAMMADKLITF
>NC_000918.1|WP_164930835.1|271125_272088_+|disulfide-reductase
MGGIGKKVAYYPGCSLEGAARAYDVSTRIVAKELGLELDYLEDYNCCGAMETKNVSFWGTMLLNARNMSLARRQGHNVIVAPCNGCSFSLQRVEYFLETDKNTLDRINQLLQEAGEKPLDNIPHTYHILEWFYHEAGPEKVKEKTKKPLRGLKVASYYGCLYTRPHFYARTYSHLAPEDEEQARPRKRETADDDEHPYYMEALLEAAGATSVEIEPMHTQCCGGPHSLSDEEVSEKFVMMILQTAKRNGADIIATECPLCHASLEMYRHRLMLKGVPDVDVPAAYFTQLLGLAFGYSVNDVKLKDNLSDPIPVLKRLGLA
>NC_000918.1|WP_010880226.1|279845_282320_+|CBS-domain-containing-protein
MVCPKVVILSEGADLDSLSAAYGVLKLYPDAYLLKPKHLSKKAGEVFKKYRDKFRVIEDLPDCFELVLVDTHFLPEGLPRERIKRIIVYDHHPIGDVKEFEGKIEKVGAATTLVVEEIKEKGIDINPRDATLLAFGIYEDTGNFTYEGTTPRDALALAFLLEKGANLREIREVVMETYTPEQIEAVGKIVQSIEKVFINGRQISFATAVLERYQPDINTLLYEIKDLKESDAFFVIIEAEGKTYVFGRSQSEDVDVGEILSHFGGGGHREAGAVKLENVSAERIKELIKAFLKRKYVKLKVRDIMNTPPFVLEEHVSVKDALTELSERGIANAPVINREGKLVGIISKKALLKLVKLYPDEPIELFVNRDFYTLSPDAPVWEAEEILTKFGQKLIPVVEDGTVVGVVTRLDILQAVKEDLEKLKEKRRKIKVPENIEEIAREVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARRETYPRPGAYPKVEPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKQGLKGKELGERIEELKREIMNKI
>NC_000918.1|WP_010880227.1|282322_283039_+|LPS-export-ABC-transporter-ATP-binding-protein
MLEVREVEKSFKKKKVLKGGSLSVNKGEIVGLLGPNGAGKTTLFNSIIGFISVDKGKVLLDGEDVTHLPPFKRAQKGLAFLPQEHTLFEDLTVLENLLIFLEFFTDSKEEAITKAEALLEDFGLLELKDQKAYALSGGQKRRLEIARSLITTPKYVLLDEPFAGLDPIIVSEIREIVKNLKNNGIGVLITDHNVRETIKMVDRVYIISEGKVLAHGKPEEVVNNEAVRKTYLGVDFKL
>NC_000918.1|WP_010880228.1|283035_284355_+|universal-stress-protein
MSVVIIGVGRYAREVLEIVTAITEVYVIEKPGEHIQKFVEEAKGLEKVKFVFESATDVETWREKVNLSEVEAVISFLKLESTLEVAKLLREFFNYEGEIIYVANERPENEELQKLKVDTVSIPNVLRVIFKNLLIGKGIIRYPVGIGLEKGEIVEITLTEYSPLVYKRLRDIKIRKARVALVYRNGKLLLPRSNLRLQSGDRLLVVGEPSSVNVFIHTATEGISDFPLNWGSAGVYCSGNEKEFNYLKEKVKVREWLEDCEKIQEIENLGLIVLEKKESGFLKKGSVDRAFEEFSVPSFHLKGTYPYEKVLASANTDAREVLLSTAVDIAVQFGSKLFILYVKPFEKMISEKEKEVIEGLKSFAERVRKITKINLELVIREGNPVRETLKFMDEESFNLLLIGYKVGRTTKLFSPYSPHLIARKSKLSTLLVPEVVLEQ
>NC_000918.1|WP_164930595.1|284344_285490_+|sodium:proton-antiporter
MSSELFLIIVFLSAFLAPLFSRILRMPVPVGELIFGILIGNFFVGIQVPEILNFLSDFGFLLLMFLAGLELDFNLIEKADKKQNAVYISYVLLIFLSAFVFGILLGIGTAPAIILSLISLGLMVATLKDMSVLEEPFAKKVLLIGVFGEIISLLALTLMEKLLHFHGFVSLIKELGVIFVFFFSFFLGFYLTRLLVWWYPEIVNRLTYEEDPSALGIRLSLFLMFTSSIFAKLAGIESVLGAFMAGVVFSYFIREKKDLEEKLSSIGYGFLIPIFFIKTGMGMEVAGLNLAILFKVFIFLAFMLFVRLIPSFVLLLAGFSLKDSFTAGLLLSYPFTLMVAGIEIARRGGALDEETALALFLTAAFSSLVFPWSAKIILSRR
>NC_000918.1|WP_165438798.1|285503_286553_+|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN
MMEFVTNYTLEELKKRFTELGLEPYRAKQVFRWVYKKFVTDFEKMTDLGKKHRELLKEHFAFHPLEKLDRVEAPDAVKYLFKTKDGHILETVLIKERDHYTLCVSSQIGCAVGCTFCATALDGLKRNLSTAEIIDQYLQVQQDLGEEKIRNVVFMGMGEPLANYENVRKAVEIMVSPEGLDLSKRRITISTSGIVAQIKRMAQDPVMKEVNLAVSLNAVSQKKREELMPLTKTNTLEELMEVLKNYPLPKYRRITLEYVLIKGVNDSPNDAERLAKLIGRHKKKFKVNLIPFNPDPNLPYERPALTDIMKFQKVLWKYGISNFVRFSKGVEVFGACGQLRTQRLQLQRV
>NC_000918.1|WP_010880231.1|286549_287209_+|ABC-transporter-ATP-binding-protein
MKVVELKNVKKIYPDGTIALKGVSLSVEEGEFLGVMGPSGSGKSTLLHLIGGLDKPSEGIVKVFGKEINHLDEDELAEMRKRKIAYVFQFYYLLEDFSVLENLTLIGELAGIKNPKKKALELLDFLRLSHRINHKPYQLSGGEQQRVAIGRALMVEPKLILADEPTGNLDSKEGFRIFELFKELNEKGITFVVATHNDSLKPFFGRIINLRDGEIVTQR
>NC_000918.1|WP_164930596.1|287195_287459_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MRAFTLLEVLIALTILGISLTVIFSLFSQSSAYLQNLKEEWEAFRVLDSKVKLGSTEGVKVEKKELKEYNVRVRIYRKGEIELLTVE
>NC_000918.1|WP_010880232.1|287455_287857_-|type-II-secretion-system-major-pseudopilin-GspG
MRRGFTLIEVLVVLIILGLLAALIVPKLTGRVDEARIESTKLQLKAVKNALEQFKLDNGFYPTTEQGLKALVEKPTTPPEPKNWKQYMEKVPKDAWGNDFIYVSPAGNKPYELKSVGPDGIEGTEDDISVWDL
>NC_000918.1|WP_010880233.1|287856_288189_-|thioredoxin-family-protein
MFEGFKEVTDKDFYKAVMMNPKPSVVVFTDPNNPANEQIKPILEKYQKLYGDKIDFFYMDVTKNTSFEDFGIFNFPAILYFRDTMELDRHDFIPTEEMVEQAIKRLLRMV
>NC_000918.1|WP_010880234.1|288188_288536_-|hypothetical-protein
MKRFRKNNLELELIRELSEIDFYNISAPLNSKEFWKEWQEKFNRANLTRIALRNILRNKRLSPKEYRKVKNSIKKYEDIINYLNALKLTALNARGSFGGYFIEFDEDEEENEGGT

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Crispr_ID: NC_000918_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_000918_5

692063-692224

Orphan

Consensus_repeat	Method
GTCGCAATCCCTCACTATTAGGGCGTAACC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_000918_5

>merge|NC_000918|5|692063-692224|CRISPRCasFinder
GGAACAATCCCTTATTGTTAGGGCGTAACTGACACCAGCAGGTCCTATCACAAGTCCCATCAAAAGGTCGCAATCCCTCACTATTAGGGCGTAACCGGTCCAAGTTGTTCCATCAGAAGAAACAGAAATGGTGTCGCAATCCCTCACTATTAGGGCGTAACC

>NC_000918|5|5|692063-692224|CRISPRCasFinder
GGAACAATCCCTTATTGTTAGGGCGTAACT	GACACCAGCAGGTCCTATCACAAGTCCCATCAAAAG
GTCGCAATCCCTCACTATTAGGGCGTAACC	GGTCCAAGTTGTTCCATCAGAAGAAACAGAAATGGT
GTCGCAATCCCTCACTATTAGGGCGTAACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_000918.1\|WP_010880626.1\|697942_701428_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|273161
NC_000918.1\|WP_010880612.1\|682301_682805_-\|biotin/lipoyl-binding-protein	unknown	unknown	gnl\|CDD\|273776
NC_000918.1\|WP_010880630.1\|703948_705178_-\|collagenase	unknown	unknown	gnl\|CDD\|223896
NC_000918.1\|WP_010880620.1\|689520_691992_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341240
NC_000918.1\|WP_010880611.1\|681086_682298_-\|transporter	unknown	unknown	gnl\|CDD\|224978
NC_000918.1\|WP_010880618.1\|686940_687537_+\|nicotinamidase	unknown	unknown	gnl\|CDD\|238493
NC_000918.1\|WP_010880621.1\|692495_693170_-\|flagellar-motor-protein-MotB	unknown	unknown	gnl\|CDD\|224279
NC_000918.1\|WP_010880622.1\|693180_693888_-\|flagellar-motor-protein-MotB	unknown	unknown	gnl\|CDD\|224279
NC_000918.1\|WP_010880616.1\|684684_685872_+\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|234866
NC_000918.1\|WP_010880623.1\|693891_694656_-\|motility-protein-A	unknown	unknown	gnl\|CDD\|224210
NC_000918.1\|WP_010880625.1\|695009_697946_+\|exonuclease-subunit-SbcC	unknown	unknown	gnl\|CDD\|129705
NC_000918.1\|WP_010880624.1\|694698_695013_+\|divalent-cation-tolerance-protein-CutA	unknown	unknown	gnl\|CDD\|224243
NC_000918.1\|WP_010880629.1\|702654_703965_+\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|225803
NC_000918.1\|WP_164930665.1\|702202_702643_+\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_010880619.1\|687605_689504_+\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NC_000918.1\|WP_164930851.1\|701439_702180_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187615
NC_000918.1\|WP_010880617.1\|685871_686903_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197753
NC_000918.1\|WP_010880613.1\|682777_683275_-\|macro-domain-containing-protein	unknown	unknown	gnl\|CDD\|234759
NC_000918.1\|WP_164930850.1\|683287_683875_-\|redoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|224910
NC_000918.1\|WP_010880615.1\|683880_684636_-\|FprA-family-A-type-flavoprotein	unknown	unknown	gnl\|CDD\|223503

Protein	Function_ID	Function_description	E-value
NC_000918.1\|WP_010880626.1\|697942_701428_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|273161	TIGR00594, DNA_polymerase_III_subunit_alpha, DNA-directed DNA polymerase III (polc). All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	0
NC_000918.1\|WP_010880612.1\|682301_682805_-\|biotin/lipoyl-binding-protein	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	6.28549e-22
NC_000918.1\|WP_010880630.1\|703948_705178_-\|collagenase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	7.2007e-113
NC_000918.1\|WP_010880620.1\|689520_691992_-\|AMP-binding-protein	gnl\|CDD\|341240	cd05914, LC_FACL_like, Uncharacterized subfamily of fatty acid CoA ligase (FACL). The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.	0
NC_000918.1\|WP_010880611.1\|681086_682298_-\|transporter	gnl\|CDD\|224978	COG2067, FadL, Long-chain fatty acid transport protein [Lipid metabolism].	2.5337e-113
NC_000918.1\|WP_010880618.1\|686940_687537_+\|nicotinamidase	gnl\|CDD\|238493	cd01011, nicotinamidase, Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).	1.93396e-90
NC_000918.1\|WP_010880621.1\|692495_693170_-\|flagellar-motor-protein-MotB	gnl\|CDD\|224279	COG1360, MotB, Flagellar motor protein [Cell motility and secretion].	1.48171e-58
NC_000918.1\|WP_010880622.1\|693180_693888_-\|flagellar-motor-protein-MotB	gnl\|CDD\|224279	COG1360, MotB, Flagellar motor protein [Cell motility and secretion].	1.71001e-75
NC_000918.1\|WP_010880616.1\|684684_685872_+\|tryptophan--tRNA-ligase	gnl\|CDD\|234866	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed.	7.80822e-101
NC_000918.1\|WP_010880623.1\|693891_694656_-\|motility-protein-A	gnl\|CDD\|224210	COG1291, MotA, Flagellar motor component [Cell motility and secretion].	3.33529e-87
NC_000918.1\|WP_010880625.1\|695009_697946_+\|exonuclease-subunit-SbcC	gnl\|CDD\|129705	TIGR00618, Nuclease_SbcCD_subunit_C, exonuclease SbcC. All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	0
NC_000918.1\|WP_010880624.1\|694698_695013_+\|divalent-cation-tolerance-protein-CutA	gnl\|CDD\|224243	COG1324, CutA, Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism].	7.06177e-46
NC_000918.1\|WP_010880629.1\|702654_703965_+\|mechanosensitive-ion-channel	gnl\|CDD\|225803	COG3264, COG3264, Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane].	1.01831e-61
NC_000918.1\|WP_010880619.1\|687605_689504_+\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NC_000918.1\|WP_164930851.1\|701439_702180_-\|SDR-family-oxidoreductase	gnl\|CDD\|187615	cd05357, PR_SDR_c, pteridine reductase (PR), classical (c) SDRs. Pteridine reductases (PRs), members of the SDR family, catalyzes the NAD-dependent reduction of folic acid, dihydrofolate and related compounds. In Leishmania, pteridine reductase (PTR1) acts to circumvent the anti-protozoan drugs that attack dihydrofolate reductase activity. Proteins in this subgroup have an N-terminal NAD-binding motif and a YxxxK active site motif, but have an Asp instead of the usual upstream catalytic Ser. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	3.16772e-51
NC_000918.1\|WP_010880617.1\|685871_686903_+\|hypothetical-protein	gnl\|CDD\|197753	smart00481, POLIIIAc, DNA polymerase alpha chain like domain. DNA polymerase alpha chain like domain, incl. family of hypothetical proteins.	1.57163e-09
NC_000918.1\|WP_010880613.1\|682777_683275_-\|macro-domain-containing-protein	gnl\|CDD\|234759	PRK00431, PRK00431, ADP-ribose-binding protein.	9.79739e-69
NC_000918.1\|WP_164930850.1\|683287_683875_-\|redoxin-domain-containing-protein	gnl\|CDD\|224910	COG1999, COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only].	5.73383e-62
NC_000918.1\|WP_010880615.1\|683880_684636_-\|FprA-family-A-type-flavoprotein	gnl\|CDD\|223503	COG0426, FpaA, Uncharacterized flavoproteins [Energy production and conversion].	1.61471e-85

>NC_000918.1|WP_010880620.1|689520_691992_-|AMP-binding-protein
MEFLRDFGKTALIHQGNEISYAELLENIASFANLMDITPNERVGIVMENRPEWVYAFYGTWKKGGIVVPIDFMSTPQEIRYILEDAEPSIIFCSDETYPRVREASEDLKVEIVNVDNLVLPTPWEGIVRRDEDDVAVLPYTSGTTGNPKGVMLTFKNLMSNIRGVSEVGIAGKEDKTLAILPFHHMYPLMTTMLLPLYLGATVVFLDKLTPEDIIEKLQKYQITVLIGVPRLYQLFHRRIMEEINKNVLAKNLFKLMKKVKNQKIRKTVFKKVHDAFGGRIKYMVSGGAKLPLDIAQDLTTLGFTVIEGYGLTETSPIVSFNPPNRIKLGSVGVPIKGVEVMTTSEGEIIVRGDNVMKGYWKKPEETQKVIINGWFYTGDLGEIDEEGYIYITGRKKEIIVLGSGKNVFPEEIESKILAKAPYIKEVGVFEKDGKLLALIYPDFEKVKELGITNLEETIKWEVIDKVNRELPEWKRVVGFKIVKTELPKTRLGKLRRFLLPQIYEKAEEIKEEKTEDYSVFETEEGRIIKEFLEKISQKEVKPGDHLEIDLGLDSLAKVELLGFIETNFGVSLSEEELSKNLVVKDLIELVRSKKKSVDTKEVSWKDILTKAKPYELYHYPLIFELGRKLLKLYFKLYHRIDVRGLENLPKPPFIIAPNHQSYLDAFAIAAVLPKEIAHETYFLGDETYFRNPITSTFGKLAHVITVNVNKGLKESLQKTAYALMSGKVVVIFPEGARTRTEELMEFKKGVAILARELGVPIVPVAIEGAYEAWSVYDKFPKPKKIKIMFGKPVDPDEKSYEEITKELYEWIKSMLEFLKKES
>NC_000918.1|WP_010880619.1|687605_689504_+|molecular-chaperone-DnaK
MAEKKEKIIGIDLGTTNSVVSVMMGDEAVVIQNQEGSRLTPSVVSWTKEKEILVGEPAKRRAILDPENTVYESKRFIGRKFEEVKEEAKRVSYKVVPDEKGDAAFDIPNAGKLVRPEEVGAHVLRKLKEAAEAFLGEPVKKAVITVPAYFNERQRQATKDAGKIAGLEVVRILNEPTAAAMAYGLHKKDNVRILVYDFGGGTFDVSILEGGEGVIEVKVTAGDTHLGGANIDERIMDWLIEEFKKETGIDLRKDRTALQRLKEASEQAKKELSFKMETEINLPFITIDPNTNQPLHLQKKLTRARLEEMIKDIVDRTIDIVKQALEDAKLKPSDIDEVVLVGGSTRIPLVQQRIKEFFGKEPHKGLNPDEVVAMGAAIQAGVLAGEVKEIVLVDVTPLSLGVETYGGVMTVLIPRNTPIPVRKCEIFTTAHDYQTEVEIHVLQGERPLAKDNKSLAKFYLTGIPPAPRGVPKIEVCFDIDADGILHVTAKDLGTGKEQSVRVEISSGLTPEEIERIIKEAEEHAEEDRKKKELIEAKNQLDHLVYQLEKALKEAGDKVPADVKSEAEKVIEEAKKTIETATEIEQVKQVTEKVLQVSSKMGTTLYGEAGKQAGGGEKKDEGGEGEVEAKPVD
>NC_000918.1|WP_010880618.1|686940_687537_+|nicotinamidase
MKVKLTDRDALIVVDMQKDFMPGGALPVPEGDKIIPRINEYVKLFEKKGLPVFYTRDWHPENHISFKGHGGIWPPHCVQGTEGAKFHEDLYIPADNKFIISKGTSQEFDAYSGFQGTILNDLLKERGVRRIFVCGVATDYCVKNTTIGGINLGYQAFVLEDAIKGVDVNPGDVERAINEMMERGAAFIKIEDIVDYKK
>NC_000918.1|WP_010880617.1|685871_686903_+|hypothetical-protein
MEFLLLPFFLFIPYILYFLYPVKFIKNFREVNEVLEPESFYIYSYAFHVHTQFSYDSLGKPEDVKKAREICGLDYVIVTDHEVDTFKLFEDKNTITGIEKKINDEKGKLQGDLIEVGDIKVISHHFKKKYRWKLERNKDYFFELINLKDSLVENKKHLFFYLFLGTFVYPVFKKSYLKNFVKVIKVEDYVKKYLSEGWENKVLGGLDHHVKVYIREVGIRFLFPSYTFSFRLLRNFLLSKKPARNKEEFLKALRSELNVISFSEKPSLFWVKNSTLFVYTPYPNVIIRIFSKDKVRTFLGSNLKFSLERGNYLVVGYIYSFRLWKFFFGVKPLFVSDLIKISC
>NC_000918.1|WP_010880616.1|684684_685872_+|tryptophan--tRNA-ligase
MRIVSGMRPTGKLHLGHYFGVIRNWVKLQEEHECFFFIADWHALTTAYKNTKELRQNIREVMIDWLALGLDPQKSVLFIQSLVKEHAELFLLFGMITPKSWLELNPTYKDLKYNLLRLTDLEKEFKEKLKERISEIVNLIPFNITKEEKFREHLLENLTQTMIEALFEGEIEPEILKRLNVSKRDFYETDTFGFLGYPVLQAADILIYKGEGVPVGEDQLPHIELSREIARRFNRLYGKIFPEPKALLTETPKIPGTDGRKMSKSYGNAVFFSDEKEEVEKKVMKMFTDPQKIRKNDPGRPEICPVFSWHKLFTKDEELVKKIEEDCRAGRLGCVECKRILLKHLEEFLEPIRERRRELEKRINEIEEVFYENSRKAREIAQKTMEEVRKAMNLP
>NC_000918.1|WP_010880615.1|683880_684636_-|FprA-family-A-type-flavoprotein
MAEQILYDTEDHKVVLFEELTPASAVEANQYLIIHKGEGILLDPGGHKVFAKLKSDISKYLPPQQIKYIFLSHQDPDIVAGINGWLLTTNAEALIPKLWYRFLPHFGLESRYEERVIPIDDKGTRVNLNGCELLVLPAHFMHSPGNFQLYDPCSKILFSGDLGASLNQPYTIVENFEEHVKYMEGFHRRYMASNKVLRFWANMVRQLDIEIIAPQHGAIFKGKDMVNKFIEWVENLECGVDLMTQEMYSIP
>NC_000918.1|WP_164930850.1|683287_683875_-|redoxin-domain-containing-protein
MRFLYLILLYILLILGCQKKESFNGILYDKPAYNFCLKTEENGKVKEVCLKDILKEKDIVLVFFGFTHCPDVCPAAMEVLKNTMKKLDEDERKRVQVVFISVDPERDTPKLVSQYAKYFDESFLGLTGTPEEIKEVAKAYKVFYEKVPQKGSNDYLVNHSALIYLITKDGKIKLIYSASKQKPNLIAEDVKKLLD
>NC_000918.1|WP_010880613.1|682777_683275_-|macro-domain-containing-protein
MDIKVVKGSITEVDADVIVNPANSRGLMGGGVAVVIKRLGGEEIEREAVEKAPIPVGSAVLTTAGKLKFKGVIHAPTMEEPAMPSSEEKVRKATRAALELADKECFKIVAIPGMGTGVGGVPKEVAARAMVEEIRKFEPKCLEKVILVDIDEEMVEAWEKVLGLR
>NC_000918.1|WP_010880612.1|682301_682805_-|biotin/lipoyl-binding-protein
MGKGSWIALIFLLLICFVFSEEIPVNVIVKGKVQKVFVKEGDTVKKAQKLLKISDELYTLKLKALEAKLMELEEKRKKAERYYRRYEEMFNRDLLAESVLEDKRTELKVLEYQIEEVRAEMERIKKLINYTEVRSPFSGKVKSVLVGEGSFVNGELTPQTVIIIERR
>NC_000918.1|WP_010880611.1|681086_682298_-|transporter
MKRLALSALLIPAISLAVGYRVPEQSIRSTGTAASYTSTVEHADSVHFNPANMSFLKDRWYFELGSRLIYLPKIKFKGNVLDPVQKRYVYVDTRSEDETHFVPYFHMVFPEVKNFRFGISFVTPAGLSKRWDDVPVSAYAKRFTLKVYELDFALSYRVNEKFSVGGGLRGVYASGKVKLYYPNVYNLKLDGDTDVKPGYYLSFTFKPTENFNISAVYRSKVDLDIEGDAKGNIGLHRVNTSGDVSVPLPAELRISGSYVWNNTTFELTLERTFWSSYDYLDFNYKDPVAENQFGKPIEKDWEDVNTYRFGLQHKFGDSFKGLLGIAYSESPIPSKSLGFELPEPKSVWILSLGGIYNLTKNWEVGFSYLYLAKDSRKVDNQRIKGEFSDISAHLFTLSVGAKF
>NC_000918.1|WP_010880621.1|692495_693170_-|flagellar-motor-protein-MotB
MAYKKKEECPKPPAWLTSFSDLMSLLLTFFILLYAMSTLEIPALEKFLSYFRKNPELYPPKNSVVPPITHPKDYAVKIKKRISKVLPPWAYQVVVAEEYIKLRLFDRIFFENGDYKLTEKGRKTLEEIAPLLIALSDEISSIRVEGHVGPTVEIKNPIIRNKWELAGRRATEVIRYLENRGVPHDKLVAVSYGDKRPLYRWRQSVLIERNNRVEINIYVKREKK
>NC_000918.1|WP_010880622.1|693180_693888_-|flagellar-motor-protein-MotB
MAYKKKEECPKPPAWLTSFGDLMSLLLTFFILLYSMSIISLEKFYQVLKGIVSAFGAQSVVFEEGTMPEGRRIEIPMENFHFRKIKYKELKKVAQEIKAEMSKRGIWSDYALTGECLRIRVNTDKFFPPGEDTLMKEAKGLILGLCYKLKPYALPVDIEGHTDNRPISTPRFPSNWELSMARAISVIEVFEKECGYPSDKLSALGYADTKPIASNDTPQGRQKNRRVEFCVKLLP
>NC_000918.1|WP_010880623.1|693891_694656_-|motility-protein-A
MDVGTIIGIIAAFLLILISILIGGSITAFINVPSIFIVVGGGMAAAMGAFPLKDFIRGVLAIKKAFLWKPPDLNDVIETIGEIASKVRKEGILALEGDIELYYQKDPLLGDMIRMLVDGIDINDIKATAEMALAQLDEKMSTEVAVWEKLADLFPAFGMIGTLIGLIQMLRNLNDPSALGPGMAVALITTLYGAILANAFAIPVANKLKKAKDMEVLVKTIYIEAIEKIQKGENPNVVKQEAAIMLGVELPEEV
>NC_000918.1|WP_010880624.1|694698_695013_+|divalent-cation-tolerance-protein-CutA
MNGYYVVLITVPVDKGEELSNFIVENKLGACVNVVPEVNSVYWWKGNIEKDKEALLVVKTSAQKFKELLEKVKSVHPYTVPEIIALPILAGNPDYLNWIEDSLK
>NC_000918.1|WP_010880625.1|695009_697946_+|exonuclease-subunit-SbcC
MRPLKLEVKGFTVYKKPQVIDFTPLKFFVIQGKTGAGKTSIIDAITYALYGKVPRYGASVATKYVLSRGEKELKVALDFSLRGRNYRVERYYREFPEDSQVRVYEEGRRLNIKANEVEKWLFKISGLDYKTFTKVILLPQGEFDRFLKESSERKKILINLLGLEELEKVRQLASETFKNLEGKREALKKEYELLKDYTPTKKEVLEKTLKNLEEELKELKETEEKLRQELKKAEEKDSLERELSQVVTKLKELENLEKEVEKLREKLEFSRKVAPYVPIAKRIEEIDKKLTELKVRKNKLTKELAVLKDELSFAQEELNRIEAEKEKFKEEKEREKELEHRLKKLQEIKEILKELSQLSSSLKEKEREYEQAKQEFEDLSERVEKGKKLVAETEEKLEKIKELFSEEEYTSLKMKERLLVELQRKLKELKEKEGQLENLTQKYKEKKKVHEKVLNELKELERELKERELHYHAHMVASYLSPGDTCPVCGGIYRGKALENVDAEGISELKHAKELKEKEEREIDTTLKLYAQKINSLKEEMEKLRNEVEELRKEIPENLKERIKKLEELRIEKEKLEHKLNKYRKALEDRQKQKEEAQAKLHKAQTELELLKEKIREKSRLVKEFKELYRVERLEDYEESLKEEINYINSKLQEIEEKEKKLRKHFEELSSRKSKLEGELSALNESINSLEEERKEKLKELANIYEVAKSPREVVELYLGDKEAELERKIKEFEESFQSLKLKKSEIEEKLKEYEGIRELSDIKGEYESVKTQLEEKHKKLGEVKRELEHLGERLKRKEELQKEISELEKKLEVYRVISNDFRGDRFQKYVSEIMLQKVVDRASEYFYKFTGNYFFELERATKGRDKDIVVVESSTSQRRPVSSLSGGETFLASLSFAFAVSDLLSGSANLESLFIDEGFGSLDQDMRERVSEILEAIKTNVNKMIGIVSHIPDFAERFTERIVVEKKGDYSEVRVIY
>NC_000918.1|WP_010880626.1|697942_701428_-|DNA-polymerase-III-subunit-alpha
MSKDFVHLHLHTQFSLLDGAIKIDELVKKAKEYGYKAVGMSDHGNLFGSYKFYKALKAEGIKPIIGMEAYFTTGSRFDRKTKTSEDNITDKYNHHLILIAKDDKGLKNLMKLSTLAYKEGFYYKPRIDYELLEKYGEGLIALTACLKGVPTYYASINEVKKAEEWVKKFKDIFGDDLYLELQANNIPEQEVANRNLIEIAKKYDVKLIATQDAHYLNPEDRYAHTVLMALQMKKTIHELSSGNFKCSNEDLHFAPPEYMWKKFEGKFEGWEKALLNTLEVMEKTADSFEIFENSTYLLPKYDVPPDKTLEEYLRELAYKGLRQRIERGQAKDTKEYWERLEYELEVINKMGFAGYFLIVQDFINWAKKNDIPVGPGRGSAGGSLVAYAIGITDVDPIKHGFLFERFLNPERVSMPDIDVDFCQDNREKVIEYVRNKYGHDNVAQIITYNVMKAKQTLRDVARAMGLPYSTADKLAKLIPQGDVQGTWLSLEEMYKTPVEELLQKYGEHRTDIEDNVKKFRQICEESPEIKQLVETALKLEGLTRHTSLHAAGVVIAPKPLSELVPLYYDKEGEVATQYDMVQLEELGLLKMDFLGLKTLTELKLMKELIKERHGVDINFLELPLDDPKVYKLLQEGKTTGVFQLESRGMKELLKKLKPDSFDDIVAVLALYRPGPLKSGLVDTYIKRKHGKEPVEYPFPELEPVLKETYGVIVYQEQVMKMSQILSGFTPGEADTLRKAIGKKKADLMAQMKDKFIQGAVERGYPEEKIRKLWEDIEKFASYSFNKSHSVAYGYISYWTAYVKAHYPAEFFAVKLTTEKNDNKFLNLIKDAKLFGFEILPPDINKSDVGFTIEGENRIRFGLARIKGVGEETAKIIVEARKKYKQFKGLADFINKTKNRKINKKVVEALVKAGAFDFTKKKRKELLAKVANSEKALMATQNSLFGAPKEEVEELDPLKLEKEVLGFYISGHPLDNYEKLLKNRYTPIEDLEEWDKESEAVLTGVITELKVKKTKNGDYMAVFNLVDKTGLIECVVFPGVYEEAKELIEEDRVVVVKGFLDEDLETENVKFVVKEVFSPEEFAKEMRNTLYIFLKREQALNGVAEKLKGIIENNRTEDGYNLVLTVDLGDYFVDLALPQDMKLKADRKVVEEIEKLGVKVII
>NC_000918.1|WP_164930851.1|701439_702180_-|SDR-family-oxidoreductase
MNVALITGVRRIGKEVAKALIDKGYSLSVVYRSSREAVEELTEYAKGKGVKVKGFRADLCAYGDYEKLVKGTYEEFGRIDAFVHLASPYERKELTETTREDLYYHFIPIAEAFFFISVECYKVMLKNEGNVKGRIVAFGDWATNISPYKGFSAYFIAKGALHTAVKVLAKEFAPHVLVNCVAPGPVMKAENYSEEEWKKILARTPLRREVSVKDVVSTTLLLLETESITGEIICVDGGRHIAGSGV
>NC_000918.1|WP_164930665.1|702202_702643_+|hypothetical-protein
MEKFIQKFFEELYLILFDYALKIAQNPIDELLIFGSIAIAYTVIYISGLFFARKINLPYIRKILEIGISVIFYFLVSLLEGKFPQVESLLLLKTLFLVQTIRVFILSLEAFQAFGFTTKLLINIFSILGGISFFIIKLSPFTRRKI
>NC_000918.1|WP_010880629.1|702654_703965_+|mechanosensitive-ion-channel
MSKTFTFLYKFSIALLLWIFLRTLFKVAIKRFKGSGFESVLNSLWFVLSASYVAFTGAWILNLVKFSVDFIVDVAVFFVIFLVYAAVFGYSVYLIGKFFGDTDGYENLLKSFKKFAYMFSIYILYKSLIYLTNIEVLVKKLERIYILETELVKISLFSFVEGIYVFFVLKYFFETLGNLFYVVYMKKDQEVEAGSFRTITVNLGLLLSLLIAGVSIGITWKAAVPIAGALGIGLGFGLQTIFNNYVSGFILLLSKNIKVGDYIEIEGKAGAAVGAGGDTIFGRVVSINILTTIVRTWDNVEVAIPNSEFLSSKIVNYSMTNPIVRVRIPFGVAYSSDPEKVREVLIRVAKRMPHVLPSPEPDVWFHEMGDSALIFILLVWVDLRRLRRLKALKSSIYYEAWKELKKEGIEIPFPQRDVWFRNKLKVEIEKDIKPEQ
>NC_000918.1|WP_010880630.1|703948_705178_-|collagenase
MRKPEILAPAGNWEGLSAALKAGAEAVYFGLDKLNQRSLKKNFSMDELGEIKEFCAEHGARAYLTLNSIVFDEDIPYVEEVLHRVKESGIDAVIAWDFAVMTKSLEMGIETHASVMTGIANSVSAKFFENLGIKRIVPAKELNLEQLKRLKRNTNLEIEAFVHGAMCMAISGRCFLSHEVFKKSGNRGECYQVCRHEFQVVIRDLNPNAKGAEYVLGEDYVLSARDLMTLDIIEHLMFLDAWKIEGRSKNPDYVYMVTKAYRTARDALLEGSFNEKLRQELIDMVSRVYHREWDSGFYFGKASFGVNESVAKEKKVYVGKVQKFYPRISVAEVKLEAGDLRLGDTIHIIGKKTGVVRQKVESMQIDGKPVEVAQKGSVIGLKTVDKVREGDKVYLIVEVEKEEELTARA

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Crispr_ID: NC_000918_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_000918_6

988518-988611

Orphan

Consensus_repeat	Method
GTTCCTAATGTACCGTGTGGAGTTGAAAC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_000918_6

>merge|NC_000918|6|988518-988611|CRISPRCasFinder
GTTCCTAATGTACCGTGTGGAGTTGAAACTTTTCGTAAGCTCTTGAAGCGCTTGTTTAAGTTCCTGTTCCTAATGTACCGTGTGGAGTTGAAAC

>NC_000918|6|6|988518-988611|CRISPRCasFinder
GTTCCTAATGTACCGTGTGGAGTTGAAAC	TTTTCGTAAGCTCTTGAAGCGCTTGTTTAAGTTCCT
GTTCCTAATGTACCGTGTGGAGTTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_000918.1\|WP_010880897.1\|986342_987302_+\|permease	unknown	unknown	gnl\|CDD\|281730
NC_000918.1\|WP_010880893.1\|983174_984641_+\|NADH-quinone-oxidoreductase-subunit-N	unknown	unknown	gnl\|CDD\|273795
NC_000918.1\|WP_164930865.1\|985004_985766_+\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|224666
NC_000918.1\|WP_010880898.1\|987291_988224_-\|class-II-fructose-1,6-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|238477
NC_000918.1\|WP_164930866.1\|989844_990717_+\|AEC-family-transporter	unknown	unknown	gnl\|CDD\|273356
NC_000918.1\|WP_164930710.1\|986096_986339_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|379063
NC_000918.1\|WP_010880905.1\|996503_998516_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_000918.1\|WP_010880890.1\|979398_979707_+\|NADH-quinone-oxidoreductase-subunit-NuoK	unknown	unknown	gnl\|CDD\|223785
NC_000918.1\|WP_010880892.1\|981655_983161_+\|NuoM-family-protein	unknown	unknown	gnl\|CDD\|223940
NC_000918.1\|WP_164930709.1\|984646_985018_+\|NAD(P)H-quinone-oxidoreductase-subunit-3	unknown	unknown	gnl\|CDD\|223908
NC_000918.1\|WP_010880891.1\|979709_981644_+\|NADH-quinone-oxidoreductase-subunit-L	unknown	unknown	gnl\|CDD\|235836
NC_000918.1\|WP_010880906.1\|998503_999496_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377509
NC_000918.1\|WP_164930711.1\|990700_992455_-\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|234900
NC_000918.1\|WP_164930712.1\|993019_993538_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367208
NC_000918.1\|WP_010880907.1\|999492_1000227_+\|ParA-family-protein	unknown	unknown	gnl\|CDD\|224113
NC_000918.1\|WP_010880899.1\|988668_989634_+\|IS5-like-element-ISAae1-family-transposase	unknown	unknown	gnl\|CDD\|376573
NC_000918.1\|WP_010880904.1\|995596_996574_+\|endoglucanase	unknown	unknown	gnl\|CDD\|225940
NC_000918.1\|WP_024015095.1\|992454_992955_-\|3-isopropylmalate-dehydratase-small-subunit	unknown	unknown	gnl\|CDD\|234762
NC_000918.1\|WP_010880896.1\|985791_986100_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|236654
NC_000918.1\|WP_164930713.1\|993506_995600_+\|cellulose-biosynthesis-cyclic-di-GMP-binding-regulatory-protein-BcsB	unknown	unknown	gnl\|CDD\|236851

Protein	Function_ID	Function_description	E-value
NC_000918.1\|WP_010880897.1\|986342_987302_+\|permease	gnl\|CDD\|281730	pfam03773, ArsP_1, Predicted permease. This family of integral membrane proteins are predicted to be permeases of unknown specificity.	2.79367e-78
NC_000918.1\|WP_010880893.1\|983174_984641_+\|NADH-quinone-oxidoreductase-subunit-N	gnl\|CDD\|273795	TIGR01770, NADH-quinone_oxidoreductase_subunit_N, proton-translocating NADH-quinone oxidoreductase, chain N. This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport].	8.77374e-151
NC_000918.1\|WP_164930865.1\|985004_985766_+\|patatin-like-phospholipase-family-protein	gnl\|CDD\|224666	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only].	7.69564e-67
NC_000918.1\|WP_010880898.1\|987291_988224_-\|class-II-fructose-1,6-bisphosphate-aldolase	gnl\|CDD\|238477	cd00947, TBP_aldolase_IIB, Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.	4.46239e-138
NC_000918.1\|WP_164930866.1\|989844_990717_+\|AEC-family-transporter	gnl\|CDD\|273356	TIGR00946, Uncharacterized_transporter_MTH_1382, he Auxin Efflux Carrier (AEC) Family. [Transport and binding proteins, Other].	7.19211e-71
NC_000918.1\|WP_164930710.1\|986096_986339_+\|thioredoxin-family-protein	gnl\|CDD\|379063	pfam13192, Thioredoxin_3, Thioredoxin domain.	2.27664e-21
NC_000918.1\|WP_010880905.1\|996503_998516_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	2.97448e-28
NC_000918.1\|WP_010880890.1\|979398_979707_+\|NADH-quinone-oxidoreductase-subunit-NuoK	gnl\|CDD\|223785	COG0713, NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion].	1.52515e-31
NC_000918.1\|WP_010880892.1\|981655_983161_+\|NuoM-family-protein	gnl\|CDD\|223940	COG1008, NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion].	1.46047e-172
NC_000918.1\|WP_164930709.1\|984646_985018_+\|NAD(P)H-quinone-oxidoreductase-subunit-3	gnl\|CDD\|223908	COG0838, NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion].	1.03718e-38
NC_000918.1\|WP_010880891.1\|979709_981644_+\|NADH-quinone-oxidoreductase-subunit-L	gnl\|CDD\|235836	PRK06590, PRK06590, NADH:ubiquinone oxidoreductase subunit L; Reviewed.	0
NC_000918.1\|WP_010880906.1\|998503_999496_+\|hypothetical-protein	gnl\|CDD\|377509	pfam05420, BCSC_C, Cellulose synthase operon protein C C-terminus (BCSC_C). This family contains the C-terminal regions of several bacterial cellulose synthase operon C (BCSC) proteins. BCSC is involved in cellulose synthesis although the exact function of this protein is unknown.	2.17946e-33
NC_000918.1\|WP_164930711.1\|990700_992455_-\|ATP-dependent-DNA-ligase	gnl\|CDD\|234900	PRK01109, PRK01109, ATP-dependent DNA ligase; Provisional.	0
NC_000918.1\|WP_164930712.1\|993019_993538_+\|hypothetical-protein	gnl\|CDD\|367208	pfam02830, V4R, V4R domain. The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons.	0.000345113
NC_000918.1\|WP_010880907.1\|999492_1000227_+\|ParA-family-protein	gnl\|CDD\|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	3.69448e-35
NC_000918.1\|WP_010880899.1\|988668_989634_+\|IS5-like-element-ISAae1-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	4.57294e-08
NC_000918.1\|WP_010880904.1\|995596_996574_+\|endoglucanase	gnl\|CDD\|225940	COG3405, CelA, Endoglucanase Y [Carbohydrate transport and metabolism].	2.85141e-147
NC_000918.1\|WP_024015095.1\|992454_992955_-\|3-isopropylmalate-dehydratase-small-subunit	gnl\|CDD\|234762	PRK00439, leuD, 3-isopropylmalate dehydratase small subunit; Reviewed.	3.58679e-101
NC_000918.1\|WP_010880896.1\|985791_986100_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|236654	PRK10141, PRK10141, DNA-binding transcriptional repressor ArsR; Provisional.	5.95556e-20
NC_000918.1\|WP_164930713.1\|993506_995600_+\|cellulose-biosynthesis-cyclic-di-GMP-binding-regulatory-protein-BcsB	gnl\|CDD\|236851	PRK11114, PRK11114, cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB.	0

>NC_000918.1|WP_010880898.1|987291_988224_-|class-II-fructose-1,6-bisphosphate-aldolase
MPLVSGKVLFEKANEYNFAIGAFNFNNMEFLKAILDAAEEEQAPVFIQTTESAIKYAGIEYLAGMVHAVKDKYSIPFALHLDHGKHVETILLAIRHGYTSVMIDYSDKSYEENLKVTKYVVSICAALGISVEAELGKLVSVEDEVVSREEVLVDPEQAKEFVDRTGIDALAPAIGTAHGAFKFKGEPKLDFERLKKVKELTGIALVLHGASGVYEEYVEKINKYGGDIKGAKGVPDEELKKAVELGINKVNTDTDLRLAFISKLRELMALEKKVIDPRKFLKPAMEEVKNIVKKRIRLYGSQGKAELFRV
>NC_000918.1|WP_010880897.1|986342_987302_+|permease
MFEIYERFADLVVYNLLGLQKGMHLAEALHFFVYDTLKIFTLLTVIIFVVSFIRSFFPLEKTREILSKHKAVALPLAAFLGILTPFCSCSAVPMFIGFVEAGIPLGAAFTFLVASPMVNEVALGLLLTLFGVKVAVLYVIFGVIVAIVAGYVIEKLNPRELIADYVFQVKLGQTQIKEMTFKERLEFAKNNVKEILGKIWIYIIIAIGIGGFIHGYVPQDIVERVAKTAGLIAVPLAVLIGIPLYSNAAGILPVIQALIAKGVPLGTALAFMMATTALSFPEFMILKQIMKPKLIAFFAGIVGISIIAVGYLFNFIFTL
>NC_000918.1|WP_164930710.1|986096_986339_+|thioredoxin-family-protein
MKEIKILSGTNCQNCELLYQVVSEIVKRKGIDAKVEKVVDIQEVLKYGVMTTPVLVVDGEVKHVGTPIPAPQKIEELIGG
>NC_000918.1|WP_010880896.1|985791_986100_+|winged-helix-turn-helix-transcriptional-regulator
MDCKELARIFYALSEPKRLCMVKLLLEREELCVCDFMRIFKESQPKISFHLKVLREAGLVTSQKRGKWNYYRLNKEAPVIPCVEKLLKDVKLEEKIQLEVKR
>NC_000918.1|WP_164930865.1|985004_985766_+|patatin-like-phospholipase-family-protein
MKRFEEVNLVLSGGAAKGIAHIGVLKALEELGIKVKRLSGVSAGAIVSVFYASGYTPDEMLKLLKEVNWLKLFKFKTPKMGLMGWEKAAEFLEKELGVKRLEDLNIPTYLCSADLYTGKALYFGRGDLIPVLLGSCSIPGIFEPVEYENFLLVDGGIVNNLPVEPLEKFKEPIIGVDVLPITQERKIKNILHILIRSFFLAVRSNSEKRKEFCNVVIEPPLEEFSPLDVNKADEIFLRGYESTLRIMRNFVKH
>NC_000918.1|WP_164930709.1|984646_985018_+|NAD(P)H-quinone-oxidoreductase-subunit-3
MEYVWILVFAGILLVIGLVMISLNALLGPREPQIYEDYPYECGVPLYDKDAQTTFHQGYYLLGLLLLLFDIEAAFLFPWSVVYRYLGVFGFIEMFIFIFILTYGLLYAWKKGALDWQFEIEEV
>NC_000918.1|WP_010880893.1|983174_984641_+|NADH-quinone-oxidoreductase-subunit-N
MDLRALIGVIEIPDLKKFLPEFILLLLAFILFTLELFIKGKERRLVLNVVSYVGYFSVLMSLLIPWMYKGDTFYGNFTNDPLAVTVKIFAVLITLAILPFASSYFSAKKSFYGEFYYILAFTLLGVFVLASTYNLIILYVALELVSVGFYILTALLRGSTEAKEGAFKYLILGGLSIALASYGAAFMYIYSGSLDLREILTYQGKDIHYLVLGLVFFLIGLAVKIGAVPFHYWVPDAYQGAPTPVTALMASVGKLAFFIPLVRVMPLVQEKFSLVWTITVGVIAALTMLYGNLVALVQKDVKRLLAYSSIAHSGYIMAGAAVAKVIGMKAVIYFLVAYAVMSAGAFLVLALMEKNPEWQNYMENFYGLRFNAPYIAFAFFVYMVALLGVPPTVGFVGKALVFMALSFDKLWWLAFIMILSAAISTGYYIRLVVVMYMHEREKEIRSAPSHLGEKFSLFALTLASVLLGVLPSLVWFLIKQSAENLFTG
>NC_000918.1|WP_010880892.1|981655_983161_+|NuoM-family-protein
MEKVGFEFPIISVSLAIPAVFAVLILFFKEKFAKYIALLGTGLTFLVSLIALFKFDFARDNVIQFYEEYTILKELGVKLSLGMDGLSLLMYFLTTLVSLIAVIWSIGDEKIKHRLKEYYIAFLLTESFVIGVFTTFNLIVFYVFYELTLLPMLFVIGIWGYKLRLYSAYKFFVYIFISSLFLLLGIASISTYHYKMNGSFTFEYLELLNLNIPNGFEIFLFLLFFIAFAVKTPIVPFHTWLPDAHGEAPTAGSVVLAAILLKMGTYALVRFNIGLFPDAALELSPYLVALGIYSIIMASWMTISQTNIKRFVAYSSVSHMGFVVTAAFLLNMEGLRASIIEMFAHGLTSAGLFMVAGYIYNKLHTFNFASLRGAIKFMPLFATITAATAFAAMGLPGGSSFWGKFLTILAAREYSTPLAFLVVFAAFFSAAYVLYFLKTLYLDVREESVLIHFKDVSGYPLVAFLMIVIPVLLVGFVPFIFFAFYNEFLVHLLKYVLKLPF
>NC_000918.1|WP_010880891.1|979709_981644_+|NADH-quinone-oxidoreductase-subunit-L
MEGLFVIFTPLIAFLIILAFGRKIGDLGSGIIASVGAGLTTLFSLVVALKAIHSPIHVKLYDFLPIGNYTLSLGFYFDSLSSLMALVVTFVATLIFVYSIGYMRDEFGKWVFKFYAYLSLFLFAMLLIVLSDNLLGIFFGWEGVGLASYLLIGYYHEQKKATKASFEAFVMNRIGDWLFIFGIIYSFYLFKTLEITQIFPKVEEVDKYALGVATMLLFGGAVGKSGQFPLHTWLPNAMAGPTPVSALLHAATMVAAGVYMVARLYPMFEATPQTLKLIVLIGAITMTMAALAGAVHNDIKKIIAFSTMSQLGYMFVALGVGDKGGAMFHLTTHAFFKALLFLAAGAVITAFHHHLYDIFKMGGLKKYMPVTYVAFMIGALSLAGVFPFSGFWSKDRIVASMYEWSGVLGVLGTIVAFITAYYAFREGFLVFHGRERWREIYDKDVHEVEGVMTVPMGLLGFLTVLTGLFGLWLEHWYVGLIGGEEKGIHLSVALVSLGVAIAGIWLAWAVYVKEVIDYNKAYESLKFIHTTFKEQFFTEKLYHNVIAGGYLVVSRVAYKVGDRTVIDGFINALYKYFFKFVKFLWKYLDIKIIDVLIHETVLTAFRLGRLSRRLQTGLVNHYILFLAVGLTFILGIMLYILDRL
>NC_000918.1|WP_010880890.1|979398_979707_+|NADH-quinone-oxidoreductase-subunit-NuoK
MKTIPLEAFLTVSMILFGLGLIGIIARRNLVTVLMSLELALNAVNIALVGADHYLGLAEGQIFALFIIALAATEAAVGLGIIIAIFRLKKVESTDEIRELRG
>NC_000918.1|WP_010880899.1|988668_989634_+|IS5-like-element-ISAae1-family-transposase
MTQWKRRSRRKGMRTRNNKQLIKLILTKSREICNTIRPSQYNKRGRPRVYEDHLIVAALLIKILENLSLRDLEERLKDLFPKVPDFTTLHYRFRKLNRGYLKELIHRTAKEIMEKLQAKEFYCLIADGTGFGYAQAYELKWKKGKELRNVKSHVKTEVLVGVVRNKAIVVDINTGKSYADENMLLRSMLKELGFRARYFLGDAYYGKSAGVLEEIKKLRMESIVPVRDTAHTRVRNMYRLWAKRNYEIRRKVYRKNRYRVEQVIGIVKNRFGDRDNVYDFEIASLYVLGRFVLYNLILLLKLLLLCLNLLRITWASSRFIL
>NC_000918.1|WP_164930866.1|989844_990717_+|AEC-family-transporter
MYEKVFFILLIIAFAYTLKRGGIFKEEHALPFINYVIYFALPFTIFKNLRFLEIGKEVLGVVLIAWGAIFLSILFAFLFGKFLKLEEKTLRAFLLVSSFGNTAFMGYPFLYALEGNEGLKYAILYDQLGSFLMVITLGLFLAIGKFDLKELILFPPFIALVLSFLLHGVRFPQFFEHSVEIISGSLIPVILFSLGLRLNFTDMKSDYRTLFSALFIKMFLVPLLILVFLKIFGLTSLPYRVALIESAMPPMVFAGVLALKYELDFRLAFSAITLGIVISLFTVPVFRILL
>NC_000918.1|WP_164930711.1|990700_992455_-|ATP-dependent-DNA-ligase
MEYRILAEFYERIEKTTSRIEMVSSLVELFKQTPKELIDKVVYLSIGKIAPEYTGLDYNFGEKLAIRALSRVLKIPALEIEKRVRQEGDLGEAGRKLYEELGFKPEGTLTVEEVYNGLLNIAKAVGIGSQERKISIFASLLKKATPLEAKYLLRTITERLRLGIGDNTILEALSIAFTGSSVNREVVERAYNLTSDLGYVAKILAEKGLEGVKQVKIQVGRPVRPMLAERMSSPILILRKLGGKCGAEYKYDGERIQAHRKGDEFYLFSRRLENITHQYPDLIEFLKEAIPHDFIVELEAVVIDPASGEIRPFQELMHRKVKYVTKYHITKYPVAGFLFDIIYLDGEDLTLKPYPERREILEKVVKRTDRIGLVPRKIVDNVEDLENFFYQAIEEGCEGLVCKSLAPNSIYQAGKRGFLWIKYKRDYKSVLADTLDLVVVGGFYGKGQRKGTFGSLLMACYDPESDMFKTVTKVGTGFTEDDFKKLEEILMPRKLNHRHPRVNSILEADMWFEPYLVLEITGAELTLSPVHTCGWGKVSPNRGIGLRFPRFTGRYRFDKRPEDATTEQEIIEMYRMQRKIRVRS
>NC_000918.1|WP_024015095.1|992454_992955_-|3-isopropylmalate-dehydratase-small-subunit
MKFRGRVWKFGDNVDTDQIIPARYLNTSDPYELAKHVMEDSEHPEFAKEHKEGDIIVAGKNFGSGSSREHAPIAIKYSGVPVVIAKSFARIFFRNAINIGLPIVEAPEAVDEIEHGDEIEVDLEKGVIKNLRTGKEYQATKFPKELQDILKAGGLMAYAKEKLASK
>NC_000918.1|WP_164930712.1|993019_993538_+|hypothetical-protein
MKFFSEKAEKKKGGVEPAVDGVLLEPSRENFTVSSFLEVIADVGDEEDLYFFQNKAAEKMSLKLAEYVREFSGKESVGLFISFLNFFLERENLGSVNYVKVDLSNKKFVVAIENSAIALALKKKYKKKVCKFYETLLSELFSDLIGVDIKFKEIQCLAEEGQREKICIFEST
>NC_000918.1|WP_164930713.1|993506_995600_+|cellulose-biosynthesis-cyclic-di-GMP-binding-regulatory-protein-BcsB
MKRFAFLKVLSLLLLIALSFSQTTSVKLSEFLGKNVLDLKGMDARGKLSFPVNPLWNVEKIKFYIYYKASPVLKSERSEITLLLNGKVITSRQIKDEGLITVEIENPKLFDFNTLTFKASQHYCINCCENENSPELWTQIDLKKSYIQFQYTKKPFPENLAFLKDIYLSERLLSPVEIDILTDKGSNRLLTAGAIFSGYLGAKIKYRRIYVNYTENLRAKDTVVIGTQDFVSRVIGERVSGNIYVTQNPKDKSKFLLVFTGRDEKEILNAVRAFILTPSSYLSEKFVYVSDVVLPEIKAYSSPVLLAPGEEITLRKIAGGDVVVRGYAGRFDFSFFIPPDLMLNPKEKLRLKLFYNHGLLVREGSTINLYINGKFVYSIPVDPYDKSDLKVREVLIPTSVLNKGFNVLTVESALVPNKEDFCAAANFESLKVIIYGNSLISLPDLVHWTKMPNLVYFISTGFPFTTYPDMKDAAVLVESTDGETLSSMFTLLAFIGTKIQFPPLRLSVYVDRLPNDVAQSKDVIVFWNRNSLIKKQILNSLDSVVLVKGKLFEEDQKEFSVNLRKRDYVFTMAMRESPFKPKRTILVLNSKSPGTLHKFVKMLYDPVVLSKIKGDTVFYDEKTDTILSSSSGQVYYIGHMPVYKKVYYEIGYNLKYLVGLLLISLLVLAFATKKLLDYRAKKRHQQEEKEGKEEEKK
>NC_000918.1|WP_010880904.1|995596_996574_+|endoglucanase
MKFFTVLLFFLSFVFSASIDVWKLWEHYKKTFISKEGYVVDPYNNYRVTSEAQGYTLLISALIGDKETFYRVWNWTKENLKRKDNLFSWLWINGHVVDRNNATDADLFIAYALLIASQKWKDYTLLSEAKRIKDSVKELVVPVCNGRRDYLFIPAKEGYIKNNIVSLNVVYYVPFIFRKFYESFGEDVWKNLYRYTYDIYTIRNISTHLTYDLFKKELRKGNFIDIDGMRFLIYAYVDDKRSLLYMRNAVEGILKFYREKGYIPLKYNYVTGGASKLKAPFCFYYVFSKLLPSDKNLEKEFRNGLEYDKKNYYCYALLLIALLHD
>NC_000918.1|WP_010880905.1|996503_998516_+|tetratricopeptide-repeat-protein
MGLSTTRRITTVTLCFLLLSYTISFAVYYVKVLETTDKAKADAVLYELVNSGIDNCNVKKAQNYVVFCGPYSSLDEARTVSSKINKLGYFTVITERIKKETKKSVRKTVEKTKTTVKKRGRVREAFLGLKVKEMYDYLNANKLVEAQTLAYSLLNTEFRNEAIFVLALINMKKGNHEKACELFSKLPDKFKPNLEELRSISCLYAEKIKEKPEVKKEEKTVYRADLTQAGKLLAQGNPEEAIELAKKVLLSDPTNVEAMLIIGDAYMELGDYSNAYSYYKMALGFDKENLRAIKGLMYASLALKRYEEAYNYARELGRLGVENGDIERVKALYLAKKAEDFVKRKEYDKAYIYLKEAEKLAPDDPYVLLLLGDIYFGRGDYTQAYKYYVEAYKRKRDFDFLLKILYALANLNNYDLINTYLSQIDVSELNEAQRRKLKNFYKVLYVKASSYYLSQKDYEKAYRIAKEGLILFPKNRTLLKNLAWSCLNLEDYKCAEENFKKALSLYENDYDALYGLALTYAREGKEGEVNKIVKKLEKKRDKETYMKIADIYVILGDYDRAEYYLNQAKKLSRAKPVKIKRVKIRPREEKLREERVESTIFYNPFIKGYEGEEKETEKEKEEKLYPFELEEKRISELEEKIKEAKKKENTDFIESGIQFSQNREEKVWTS
>NC_000918.1|WP_010880906.1|998503_999496_+|hypothetical-protein
MDKLIHTSVYLNAEKKLARGFYLWTENDLIFLDSGGKPDYTHFGGINLPVIRDTDTSFIGIEPMVGVRVGRKSYLKLGIGSTPFGNSKVRPTFRGIFEANYREEDILLRLTLKRDSVRDSLLSYVGAKDPHADREWGRVVEQGGEVKFQLGSGYRESFLSLKGGYYDIEGKNVNDNSRYFLEIYPSLYLGNLLIDENYLGLFFRYENYDKNENLFYFGNGGYFSPKNFVLLGPKYTGYFYTDRLMFRLNLLLGFLRFETDGDTTNTLAADISGEFEYKLKEKISLIGGLGYRNSKDYDEVSLNMGVKYYFNGLESPFRSTVDKVDERLFK
>NC_000918.1|WP_010880907.1|999492_1000227_+|ParA-family-protein
MIIPVLSSKGGVGKTTIATNLAYTLSKKAKTVLIDTDPQNGVASVLCKRHDIGLADILLEGTNYGETLRQVRENFFIIPTGAKAIENEFSFNESFKYENIQNLCLKLESEGGFEFILFDTPPGYTVQSNVLMKLADVILAVFEAEPASYASFKVFETHMFTKEKEIREKLWLIINKVRASEISEDFSFIFRYEAGGNILAYLPYDEAVSVASGECLLVEEYKPDSPFVKLMYELVEKLLTLLKK

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Crispr_ID: NC_000918_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_000918_7

1226626-1226861

Orphan

Consensus_repeat	Method
CGTTTCTAATGTACCGTAGAGGAGTTGAAAC	CRT
GTTTCTAATGTACCGTAGAGGAGTTGAAACC	PILER-CR
GTTTCTAATGTACCGTAGAGGAGTTGAAAC	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_000918_7

>merge|NC_000918|7|1226626-1226861|CRT,PILER-CR,CRISPRCasFinder
GGTTTCTAATGTACCGTAGAGGAGTTGAAACCAGAACAATAAGAGAGCCGATTGATGAGAACGCAGACGTTTCTAATGTACCGTAGAGGAGTTGAAACAGATATGATACACCTGAAACATTCTTTTACATGGACCGTTTCTAATGTACCGTAGAGGAGTTGAAACCCGGCGGATATAAAAATCGCCTACCTATACGCCGTAATGGCGTTTCTAATGTACCGTGTGGAGTTAAAACA

>NC_000918|7|4|1226626-1226861|CRT
GGTTTCTAATGTACCGTAGAGGAGTTGAAAC	CAGAACAATAAGAGAGCCGATTGATGAGAACGCAGA
CGTTTCTAATGTACCGTAGAGGAGTTGAAAC	AGATATGATACACCTGAAACATTCTTTTACATGGAC
CGTTTCTAATGTACCGTAGAGGAGTTGAAAC	CCGGCGGATATAAAAATCGCCTACCTATACGCCGTAATGG
CGTTTCTAATGTACCGTGTGGAGTTAAAACA

>NC_000918|7|4|1226627-1226791|PILER-CR
GTTTCTAATGTACCGTAGAGGAGTTGAAACC	AGAACAATAAGAGAGCCGATTGATGAGAACGCAGAC
GTTTCTAATGTACCGTAGAGGAGTTGAAACA	GATATGATACACCTGAAACATTCTTTTACATGGACC
GTTTCTAATGTACCGTAGAGGAGTTGAAACC

>NC_000918|7|7|1226627-1226790|CRISPRCasFinder
GTTTCTAATGTACCGTAGAGGAGTTGAAAC	CAGAACAATAAGAGAGCCGATTGATGAGAACGCAGAC
GTTTCTAATGTACCGTAGAGGAGTTGAAAC	AGATATGATACACCTGAAACATTCTTTTACATGGACC
GTTTCTAATGTACCGTAGAGGAGTTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_000918.1\|WP_010881130.1\|1225913_1226345_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|225308
NC_000918.1\|WP_165438794.1\|1232304_1232460_-\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_010881126.1\|1222226_1223321_+\|J-domain-containing-protein	unknown	unknown	gnl\|CDD\|223560
NC_000918.1\|WP_010881129.1\|1225415_1225934_+\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|224565
NC_000918.1\|WP_010881123.1\|1217399_1219727_+\|phenylalanine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|273097
NC_000918.1\|WP_010881128.1\|1224573_1225443_+\|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	unknown	unknown	gnl\|CDD\|260116
NC_000918.1\|WP_164930756.1\|1231322_1231631_-\|dephospho-CoA-kinase	unknown	unknown	unknown
NC_000918.1\|WP_010881132.1\|1227659_1228937_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NC_000918.1\|WP_010881135.1\|1232470_1233649_-\|tyrosine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235645
NC_000918.1\|WP_164930757.1\|1231708_1231942_-\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_164930755.1\|1229798_1231208_-\|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase	unknown	unknown	gnl\|CDD\|273435
NC_000918.1\|WP_010881124.1\|1219922_1220483_+\|5-formyltetrahydrofolate-cyclo-ligase	unknown	unknown	gnl\|CDD\|274270
NC_000918.1\|WP_024015106.1\|1217119_1217353_-\|sulfurtransferase-TusA-family-protein	unknown	unknown	gnl\|CDD\|238180
NC_000918.1\|WP_010881131.1\|1226886_1227642_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133005
NC_000918.1\|WP_024015105.1\|1216817_1217123_-\|DsrE-family-protein	unknown	unknown	gnl\|CDD\|376874
NC_000918.1\|WP_164930753.1\|1228915_1229527_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NC_000918.1\|WP_010881125.1\|1220469_1222146_+\|ribonuclease-Y	unknown	unknown	gnl\|CDD\|237177
NC_000918.1\|WP_164930758.1\|1232065_1232299_+\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_164930754.1\|1229523_1229817_-\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_010881127.1\|1223291_1224494_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|367049

Protein	Function_ID	Function_description	E-value
NC_000918.1\|WP_010881130.1\|1225913_1226345_-\|EamA-family-transporter	gnl\|CDD\|225308	COG2510, COG2510, Predicted membrane protein [Function unknown].	5.65159e-18
NC_000918.1\|WP_010881126.1\|1222226_1223321_+\|J-domain-containing-protein	gnl\|CDD\|223560	COG0484, DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones].	3.64395e-139
NC_000918.1\|WP_010881129.1\|1225415_1225934_+\|DsbA-family-protein	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	1.4142e-23
NC_000918.1\|WP_010881123.1\|1217399_1219727_+\|phenylalanine--tRNA-ligase-subunit-beta	gnl\|CDD\|273097	TIGR00472, Phenylalanine--tRNA_ligase_beta_subunit, phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial. Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation].	0
NC_000918.1\|WP_010881128.1\|1224573_1225443_+\|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	gnl\|CDD\|260116	cd13944, lytB_ispH, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase. The 4-hydroxy-3-methylbut-2-enyl diphosphate (HMBPP) reductase (called lytB or ispH) is the terminal enzyme of the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, one of the two metabolic routes for isoprenoid biosynthesis. The MEP pathway is essential in many eubacteria, plants, and the malaria parasite. LytB converts HMBPP into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).	1.74405e-149
NC_000918.1\|WP_010881132.1\|1227659_1228937_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.89016e-38
NC_000918.1\|WP_010881135.1\|1232470_1233649_-\|tyrosine--tRNA-ligase	gnl\|CDD\|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
NC_000918.1\|WP_164930755.1\|1229798_1231208_-\|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase	gnl\|CDD\|273435	TIGR01085, UDP-N-acetylmuramyl-tripeptide_synthetase, UDP-N-acetylmuramyl-tripeptide synthetase. Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NC_000918.1\|WP_010881124.1\|1219922_1220483_+\|5-formyltetrahydrofolate-cyclo-ligase	gnl\|CDD\|274270	TIGR02727, Uncharacterized_protein_YqgN, 5,10-methenyltetrahydrofolate synthetase. This enzyme, 5,10-methenyltetrahydrofolate synthetase, is also called 5-formyltetrahydrofolate cycloligase. Function of bacterial proteins in this family was inferred originally from the known activity of eukaryotic homologs. Recently, activity was shown explicitly for the member from Mycoplasma pneumonia. Members of this family from alpha- and gamma-proteobacteria, designated ygfA, are often found in an operon with 6S structural RNA, and show a similar pattern of high expression during stationary phase. The function may be to deplete folate to slow 1-carbon biosynthetic metabolism. [Central intermediary metabolism, One-carbon metabolism].	1.88648e-68
NC_000918.1\|WP_024015106.1\|1217119_1217353_-\|sulfurtransferase-TusA-family-protein	gnl\|CDD\|238180	cd00291, SirA_YedF_YeeD, SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.	6.13775e-20
NC_000918.1\|WP_010881131.1\|1226886_1227642_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	3.97055e-88
NC_000918.1\|WP_024015105.1\|1216817_1217123_-\|DsrE-family-protein	gnl\|CDD\|376874	pfam02635, DrsE, DsrE/DsrF-like family. DsrE is a small soluble protein involved in intracellular sulfur reduction. This family also includes DsrF.	4.40151e-10
NC_000918.1\|WP_164930753.1\|1228915_1229527_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	2.02039e-69
NC_000918.1\|WP_010881125.1\|1220469_1222146_+\|ribonuclease-Y	gnl\|CDD\|237177	PRK12704, PRK12704, phosphodiesterase; Provisional.	0
NC_000918.1\|WP_010881127.1\|1223291_1224494_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|367049	pfam02353, CMAS, Mycolic acid cyclopropane synthetase. This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.	1.2131e-150

>NC_000918.1|WP_010881130.1|1225913_1226345_-|EamA-family-transporter
MENLKAVFWALLAAFIWGTAPIFFKLGMKGEMPTLAGIFVHNLTATSLAFIGLLLLRENPFAYPLKEILSVALGGILGGFLGLWVYYKAVKVGDVSIVAPVAASSPLFSTLLAYLILGEGLSFQKIIGALLIVLGVALVSASR
>NC_000918.1|WP_010881129.1|1225415_1225934_+|DsbA-family-protein
MRRAIGFLLIVITFTFASLYEEFVKEQVKELPLDKAVVVGTGKKELIIFVNPDCPHCRHEWKSLREHLDKLKIYVFVVPFKAWGEDNLKKAYYIVCSQNPEKALDEVLTGKVDGKNLNPPTCELLNYHLKAADIVGLRGVPLNIIPDKGKVIEGASPKLLEELGITSAGSRD
>NC_000918.1|WP_010881128.1|1224573_1225443_+|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase
MVDIIIAEHAGFCFGVKRAVKLAEESLKESQGKVYTLGPIIHNPQEVNRLKNLGVFPSQGEEFKEGDTVIIRSHGIPPEKEEALRKKGLKVIDATCPYVKAVHEAVCQLTREGYFVVLVGEKNHPEVIGTLGYLRACNGKGIVVETLEDIGEALKHERVGIVAQTTQNEEFFKEVVGEIALWVKEVKVINTICNATSLRQESVKKLAPEVDVMIIIGGKNSGNTRRLYYISKELNPNTYHIETAEELQPEWFRGVKRVGISAGASTPDWIIEQVKSRIQEICEGQLVSS
>NC_000918.1|WP_010881127.1|1223291_1224494_-|class-I-SAM-dependent-methyltransferase
MIKEAIVERIVNKLNENQKEKIGVELPSGKRIPEFPVSHLIRFKTWKSLDYVLKDPEMGFGEGYMNGDIEVEGDLEEVIKRGMTLFKDTRKFEKLFGILRHVPLFRTIRDERNVKHHYDLGNDFYRLWLDKSMTYSCAFFEDPSMSIDEAQSLKRRIIYEKLQLKEGDTLLDIGCGWGSIILESAELYNVKSVGITLSDNQYEYVKEEIKKRGLQDKVEVYKLHYVDLPKLGRKFNKVVSVGMFEHVGKENYETFFNTVYKVMEEGGLFLLHTIGKLHPDTQSRWIRKYIFPGGYLPSISEIVESFRDMDFTLIDFDNWRMHYYWTLKKWKERFYENLDKIRNMFDDRFIRMWELYLTASAVSFLIGSNYVFQILLSKGVKDDYPVIKREFSGVLFKEGT
>NC_000918.1|WP_010881126.1|1222226_1223321_+|J-domain-containing-protein
MSQAVKDYYEILGVNRDATKEEIKKAYRKLVRIYHPDINPDPSAQEKFKEINEAYHVLIDDERRSEYDAILSRNDVGKFRDFLEYIQEFVESIIQGEKGKKRRPRKGQDIKMKLPLTLEEAGLGCEKEIIYSRWMDCPVCEGMGVKGEAETVVCHACNGEGRRVSGIFNFPRPCSVCKGKGFIVKNPCPTCYGRGRVSAQHKIKVHIPPGTEEGEVLKVPEKGHLGYFGGKPGDLYLKVVLKEHPIFKKVGKDLHMEKVVSFPLAVLGGTVKVPTLEGEEIDVFIQPGTECGATKVVKEKGYPYENGRGDLIIHIRIGVPKNLSKSERKLLEKLAESIKEEGEEVYREGGSLVEKLSSLFKKNA
>NC_000918.1|WP_010881125.1|1220469_1222146_+|ribonuclease-Y
MDVLSILLILVAVGVGIFVGRQFLGQKQAPAPTYQPVPSPQILEEAKSKAEEIIKEAKEKAEVILKEAKESAEKIVREAEEKAEKLIREAKEEVERIKEEVERRKKELKEREENVLAKERHLDRRWEALEKREEELLHRERELKDFERSLERWRDEIRHKEEELKHMKEEVEELKKKELEELQRIAKLTLEEARQEIIKKVEEEAKKDAVKLMKVIEEDAKRRAEFEAKKIIATATQRLAPQIAVNYTTTTVELPSNEFKGRIIGREGRNIRTFEILTGVDLIIDDTPDIVTISSFDPLRREIAKEALQRLIADGRIHPARIEEVVDEVKREFDEKIRKIGEETVYELDLHDINPGLYYYIGKLYFRTSYSQNVLLHSKEVAYIAGLMAEELGLDAKLARRAGLLHDIGKAISHELGGSHTDIGVELARKYGEPDAVINAIRAHHEEEPVRYPEVALVCAADALSAARPGARRETLEAYIRRLEKLEEIVKSFKGVANAYAVQAGREVRVIVNPEEISDEEAYLLSKEIPKKIEEELDFPGQIKVVVIRETRHVEYAK
>NC_000918.1|WP_010881124.1|1219922_1220483_+|5-formyltetrahydrofolate-cyclo-ligase
MLKSELRKKVLHKRINLSEEERRRLSEKVISNLKSLPEFKKSKKVALYCPIKGEVDLTPLFPEVLKEKELILPKVEGNEISLYRVHSPACLGVGAFGIMEPVEGERVNPEDVDFIAVPGVAFDLEGYRLGFGKGYYDRLLKRVKGLKVGVAYSFQVFERLPRDAWDIPVDVLVTEKNVRRLRDGRS
>NC_000918.1|WP_010881123.1|1217399_1219727_+|phenylalanine--tRNA-ligase-subunit-beta
MKVPYSWLSEFVELSDVSPEEIAEKLSLRSVEATVETFGIDLDGVVFGKVVEVKEHPTKKKLAVVKVQVQEHIFIDVVTVDKSVREGDGVIVALPNAKVGNMCVTEREFDGVVSKGLLLSAQELGLEEKSEGVLKIHEDFKPGTDANEILGFGEKIIEIDITPNRGDMLSVRGVARDLSAIFRLPKKKPEEPTYEETGEFFIEIEDEDCKRYRGVVIEGVEIKESPLYIKKRLWQCGIKSINNVVDITNYVMLRDGQPLHAFDLSKVEGGIIVRSAKKGEKIITLDGEERELDEDILVIADREKPLAVAGVIGGLESGIKENTKDILLESAYFNPFRVRKASKKLGIQTESSYRFERNVDIERVDRAQDYAVYLILKHAGGKVKVVKDVYREKYKPKKVFLPQGKYIRYAGESYKNEEVKEILDALEIPNEIMRCGVEVLVPSHRSFDIQRDVDLIEEIMRVKGYEHYTSETLKLPSIANLWKDNLLEVKKYLRDKGLTEVINFSFEDSKLYELLNLPLPELEVINPLNPTQRYMRNTLITSLLRTAVYNDRNYNYDQAVFELGKVFFKEGEENRLGILLKGNKPRTLKEEKWEPYDLTEIIAGIFALFGLEPEFRNAKRNFLHPYVQGEVYLEGEFVGFFGKLHPKIAKELELKGEPFVAEIEIERVLSKKRLPHYREVAKFPPVVRDIALVMDKELDVNKLLIDTKSQIGELLEEVRVFDVYTGEKVGEGKKSVAVRLVLRSKTGSLKDEEANELVNKLVNYLKEKYGVELRT
>NC_000918.1|WP_024015106.1|1217119_1217353_-|sulfurtransferase-TusA-family-protein
MKVDKELDIRGEVCPFTFVKSKLALEEMETGQILRVLVDYPPSAESVPKSMREEGQEVIAVNQIGENLWEIIIKKVK
>NC_000918.1|WP_024015105.1|1216817_1217123_-|DsrE-family-protein
MKILLFITSVPFAKDYNTIRNLTKYLCESGHEVTIFLSGNGVYYLLRPDAEELKNFGARVMFCSHAAHQRGVKEFPEWAESSSTYSLSQMMKDFDKTICFN
>NC_000918.1|WP_010881131.1|1226886_1227642_-|glycosyltransferase-family-2-protein
MDRLSVVILTKNEERNIARAIKSVKEIADEILVIDSGSTDRTVEIAKELGARVIFRDFTNYPDQVSFAISKTNNKWVFVLDADEEVSEELKRSIKETLKFPKHDCYVVNRRTYFMGKFLNHTLYPEWRIRVFKKDKVKYEGELHEVVKCSGSIGKLKGDLYHYSFKNLDEFFSKNLKYSKISAEILYKNGRIVKNYELFTRPVWTFFKFFIMKRGFLDGWRGFLISASYAFFNFTKYAYLKELQITKNKLR
>NC_000918.1|WP_010881132.1|1227659_1228937_+|M23-family-metallopeptidase
MKKKLIGILLVLVVIVALGFYFLVLTKPRVLNVEEFSSIPRKKIVRLKIEHADKAQLLRVLILQNGKEYVVYEGKPMPEVLLEIHPKKLGLKEGEAEVVIELSRFYFLKEKYSIRSHIDYTPPLVNVVFSPYAVMNGGSGAVRVSVSEESDLKLSVKDLIFPFYKIAGNTYFSLFGVPIDFSPSDSIKIIAKDKVGNESVVLVPVRIRQKHYPVYKIELKGREKVLIPKLSSLLGEEINKSNFIQAFKKVNEDLRRENEEKISEIGKKSEERIYWSGKFLQLKNSKVVSLYGEKRIYTYGGKQISTSYHWGYDLASVKNSPVEASNSGRVVFTGFLGIYGNTVIIDHGYGLMSIYSHLAEFRVKEGDIVKKGQIIGVTDTTGLAFGDHLHFGIMINGLPVNPIEWWDKKWIKNNILPAIQSSTSR
>NC_000918.1|WP_164930753.1|1228915_1229527_-|histidine-phosphatase-family-protein
MKKIYLIRHAQSEYNEKGIFQGRLDSDLTPLGFVQSRLLVKQFEREKPEVIITSPQRRAYKTALTLSDVLGIDLIVDERIREMSFGVLEGRHFWTMFEENKEMIINWLKDPVKYPLPTQEDIKEFEKRIKEFLEDLKSRKEKVLAVVGHGGTLHGLLCLALGIGLEKMWHIHMDNTGISLLEYDGERFYLKSLNDTCHLLVLD
>NC_000918.1|WP_164930754.1|1229523_1229817_-|hypothetical-protein
MYREGLNPKGGPCDFETLYYHVKQELLEIFKNADRPIPRVKIKELKSAQICGLVNLAKVLLYLENLGVVTVVNKEYYYQEWEIDIQPQVLDVLFEQI
>NC_000918.1|WP_164930755.1|1229798_1231208_-|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase
MDLSFILKRVKGITLNSKEVKKGYLFFAIKGTRFDGHNFIREAEERGAYAVVVERPVSSKVPVIIVEDTRKALGKSAHEFFGKPSERLNVIGITGTNGKTTTTHLIEKILLEAGEKTGLIGTIYYRLGEKILGSGRTTPDQITWHRTLKEFYELGAKNVVAEISSHALDQYRVYPTRFEAVLFTNLSQDHLDYHKTMEDYFASKAKLFTEYESKVKIINADDTYGKRLLKITHGEIITYGKKGDLKILNFRTDFRGSALRIAFKGKEYEFSTNLIGDFQAYNLSAAIAYALWKGIEPDLIQRALKCVNVPGRFEVVHSDKFTVIIDYAHTPDAVENVLRTARKLSKGKLISVFGAGGNRDREKRPLMGKAAEKYSDLIILTSDNPRDEEPEKIIEDILDGISEKDKVIIEADRRKAIKKAIDMAKEGDMVAILGKGHEDYQEIKGVKYPFSDAQVVKEILGGDGCIGKD
>NC_000918.1|WP_164930756.1|1231322_1231631_-|dephospho-CoA-kinase
MKYDWTKYKTKILELKEIFKNKTEGINVDVDVVTPEDPDFDPKMQLPYIRVRYYVEDDHAHERKIELFEHLIKKDIDEIVREVEFFIQEFESEIDASEYGGG
>NC_000918.1|WP_164930757.1|1231708_1231942_-|hypothetical-protein
MPAVAEAKVYGQDILRDKNILDKSTGNPPLEIRIEEDNIVIVKESGEERVPVNSLRGKAILTRLETGISEFTEPIYV
>NC_000918.1|WP_164930758.1|1232065_1232299_+|hypothetical-protein
MQRKEISQETVNLLVDIIKETIGEGGLKSITKRLEGRDLKGRELVYAFAEEVMNIYGQKGSYALIRQLGRDLANMFL
>NC_000918.1|WP_165438794.1|1232304_1232460_-|hypothetical-protein
MKGEALIFMLFSWLLICSLSTFCFTMLLTHQEKPSEKRETFISEEEREEIT
>NC_000918.1|WP_010881135.1|1232470_1233649_-|tyrosine--tRNA-ligase
MTPEEQLRIIKEGTVEIIEEEELLKKLKEGRPLRVKAGFDPTAPDLHLGHVVLLQKLRQFQQLGHEVFFIIGDFTAMIGDPTGRSQTRPPLSREQVLENAKTYEHQVFKVLIPEKTTVVFNSTWLEELGTKGLIELCAKYTVARMLEREDFSKRFKEGIPIYIHEFIYPLLQAYDSVAIKADVEIGGTDQKFNLLIGRDIQREYGQEPQVCITLPLLVGTDGVRKMSKSYGNYVGITEDPKTMFAKIMSIPDEIMWDWFLLLTDYNKEEIEKMRREMHPMEAKKLLAFTIVKRFHSEEEARKAKEWWEKTFSQREFPEDAPLVKLNEKKLRAVDFLVKIGAVKSKNEARRVIQGGGLKINGEKVTDPNTEIEINGELKVKVGKKKFYRVVSG

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Crispr_ID: NC_000918_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_000918_8

1249189-1249354

Orphan

Consensus_repeat	Method
GTTTCTAATGTACCGTGTGGAGTTGAAAGTTGAAA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_000918_8

>merge|NC_000918|8|1249189-1249354|CRISPRCasFinder
GTTTCTAATGTACCGTGTGGAGTTGAAAGTTGAAAGAGCTAAAGCAACCGCACCGATGGTTATGAGTTTCTAATGTACCGTGTGGAGTTGAAAGTGGAAAATGCTGCAAAAACAAAAAGGAAAAAGCTGAGGTTCCTAATGTACCGTGTGGATGTATATTCATAAG

>NC_000918|8|8|1249189-1249354|CRISPRCasFinder
GTTTCTAATGTACCGTGTGGAGTTGAAAGTTGAAA	GAGCTAAAGCAACCGCACCGATGGTTATGA
GTTTCTAATGTACCGTGTGGAGTTGAAAGTGGAAA	ATGCTGCAAAAACAAAAAGGAAAAAGCTGAG
GTTCCTAATGTACCGTGTGGATGTATATTCATAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_000918.1\|WP_024015107.1\|1241053_1241488_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180674
NC_000918.1\|WP_010881149.1\|1248005_1248875_-\|class-I-tRNA-ligase-family-protein	unknown	unknown	gnl\|CDD\|234743
NC_000918.1\|WP_164930878.1\|1241605_1242745_+\|inositol-3-phosphate-synthase	unknown	unknown	gnl\|CDD\|224180
NC_000918.1\|WP_164930762.1\|1245233_1245518_+\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|376586
NC_000918.1\|WP_164930763.1\|1246283_1246451_-\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_165438795.1\|1243107_1245111_+\|transketolase	unknown	unknown	gnl\|CDD\|223100
NC_000918.1\|WP_010881153.1\|1251716_1252013_+\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NC_000918.1\|WP_010881155.1\|1254810_1255521_-\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_164930765.1\|1249357_1250086_+\|uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|235647
NC_000918.1\|WP_010881142.1\|1238128_1238974_-\|bacteriocin	unknown	unknown	gnl\|CDD\|224573
NC_000918.1\|WP_164930766.1\|1252006_1254337_-\|glutamine-synthetase-adenylyltransferase	unknown	unknown	gnl\|CDD\|224309
NC_000918.1\|WP_164930767.1\|1254344_1254809_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224309
NC_000918.1\|WP_010881152.1\|1250898_1251639_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223993
NC_000918.1\|WP_164930764.1\|1246567_1247959_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273050
NC_000918.1\|WP_164930768.1\|1256068_1256464_-\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_010881151.1\|1250093_1250942_+\|UDP-3-O-[3-hydroxymyristoyl]-N-acetylglucosamine-deacetylase	unknown	unknown	gnl\|CDD\|223845
NC_000918.1\|WP_010881147.1\|1245527_1246301_+\|ribonuclease-HIII	unknown	unknown	gnl\|CDD\|129799
NC_000918.1\|WP_010881157.1\|1256564_1257410_-\|fumarate-hydratase	unknown	unknown	gnl\|CDD\|180486
NC_000918.1\|WP_164930879.1\|1255531_1256050_-\|translation-initiation-factor-IF-3	unknown	unknown	gnl\|CDD\|234582
NC_000918.1\|WP_010881143.1\|1239006_1241043_-\|primosomal-protein-N'	unknown	unknown	gnl\|CDD\|224119

Protein	Function_ID	Function_description	E-value
NC_000918.1\|WP_024015107.1\|1241053_1241488_-\|hypothetical-protein	gnl\|CDD\|180674	PRK06733, PRK06733, hypothetical protein; Provisional.	5.00366e-20
NC_000918.1\|WP_010881149.1\|1248005_1248875_-\|class-I-tRNA-ligase-family-protein	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	1.54699e-119
NC_000918.1\|WP_164930878.1\|1241605_1242745_+\|inositol-3-phosphate-synthase	gnl\|CDD\|224180	COG1260, INO1, Myo-inositol-1-phosphate synthase [Lipid metabolism].	0
NC_000918.1\|WP_164930762.1\|1245233_1245518_+\|30S-ribosomal-protein-S20	gnl\|CDD\|376586	pfam01649, Ribosomal_S20p, Ribosomal protein S20. Bacterial ribosomal protein S20 interacts with 16S rRNA.	1.46842e-23
NC_000918.1\|WP_165438795.1\|1243107_1245111_+\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NC_000918.1\|WP_010881153.1\|1251716_1252013_+\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	3.5564e-50
NC_000918.1\|WP_164930765.1\|1249357_1250086_+\|uroporphyrinogen-III-synthase	gnl\|CDD\|235647	PRK05928, hemD, uroporphyrinogen-III synthase; Reviewed.	9.13998e-60
NC_000918.1\|WP_010881142.1\|1238128_1238974_-\|bacteriocin	gnl\|CDD\|224573	COG1659, COG1659, Uncharacterized protein, linocin/CFP29 homolog [Function unknown].	4.15746e-148
NC_000918.1\|WP_164930766.1\|1252006_1254337_-\|glutamine-synthetase-adenylyltransferase	gnl\|CDD\|224309	COG1391, GlnE, Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms].	0
NC_000918.1\|WP_164930767.1\|1254344_1254809_-\|hypothetical-protein	gnl\|CDD\|224309	COG1391, GlnE, Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms].	3.05516e-06
NC_000918.1\|WP_010881152.1\|1250898_1251639_-\|hypothetical-protein	gnl\|CDD\|223993	COG1066, Sms, Predicted ATP-dependent serine protease [Posttranslational modification, protein turnover, chaperones].	9.05344e-91
NC_000918.1\|WP_164930764.1\|1246567_1247959_-\|FAD-binding-protein	gnl\|CDD\|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	1.22342e-165
NC_000918.1\|WP_010881151.1\|1250093_1250942_+\|UDP-3-O-[3-hydroxymyristoyl]-N-acetylglucosamine-deacetylase	gnl\|CDD\|223845	COG0774, LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane].	1.52003e-130
NC_000918.1\|WP_010881147.1\|1245527_1246301_+\|ribonuclease-HIII	gnl\|CDD\|129799	TIGR00716, Ribonuclease_HIII, ribonuclease HIII. This enzyme cleaves RNA from DNA-RNA hybrids. Two types of ribonuclease H in Bacillus subtilis, RNase HII (rnhB) and RNase HIII (rnhC), are both known experimentally and are quite similar to each other. The only RNase H homolog in the Mycoplasmas resembles rnhC. Archaeal forms resemble HII more closely than HIII. This model describes bacterial RNase III. [DNA metabolism, DNA replication, recombination, and repair].	6.87248e-130
NC_000918.1\|WP_010881157.1\|1256564_1257410_-\|fumarate-hydratase	gnl\|CDD\|180486	PRK06246, PRK06246, fumarate hydratase; Provisional.	0
NC_000918.1\|WP_164930879.1\|1255531_1256050_-\|translation-initiation-factor-IF-3	gnl\|CDD\|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	2.86141e-90
NC_000918.1\|WP_010881143.1\|1239006_1241043_-\|primosomal-protein-N'	gnl\|CDD\|224119	COG1198, PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair].	9.35517e-141

>NC_000918.1|WP_010881149.1|1248005_1248875_-|class-I-tRNA-ligase-family-protein
MKIKDFLQENKISVGDNAIFLLEKLGIKDENLIKFLEREIGESAKMSKSKANVVDPEEAVEKYGADTVRLYILFAAPPEQDFEWTDEGIQGAYRFLQRYWNFVNKHLEKIKNLTYTVEELRNVQGKAKEVRREIHQTIADYRRDFEERYQFNTAIAKIMKLLNTLQDFSPQTEQDYKVLREGIETITLLLSPITPHIAEEVWEMLGNEGFIINQPIPEPDPEALKVEEIEIPVQVNGKLRARVKVPADADEETVKNIVLSDERVQKWVQGKEVKKFIYVKGKLVNVVVK
>NC_000918.1|WP_164930764.1|1246567_1247959_-|FAD-binding-protein
MEVLTNSKVEKLKKALGEKKVKDSIVERKLYAYDATPIPIQRAIPSAVVFPENKEDVIKLVEVCYEEDIPIFPRGAGSGLTGGAVPTIEEGIVVSFEKMDKFTVDVDNATAVVQPGVITYQFQEYVEKLGLFYPPDPSSFKYSTIGGNVAENAGGPRCLKYGVTREYVLGLETVIKNGEVIRTGRPVLKDVAGYDLTKLLVGSEGTLGLFTEITLKLIPKPKARMTALALFDDLETVGKAVTKILTSGVFPSALEFMDRDAIRAVEDFKPVGLPRDVEALLLIEVDGHPLTVKEEIKEVGKILEELGAKVQVAQSEEEAQKLWSARKNLGPALGNLKTGKINEDIVFPRTYLHEALPKLREIAKKYNLTMVVFGHIGDGNLHVNLLYDKSNKEEEERAERAVDEVFELALNYNGSITGEHGVGLTKRKFLKWQFGETGYELLKGIKKLFDPKNLFNPGKVLEL
>NC_000918.1|WP_164930763.1|1246283_1246451_-|hypothetical-protein
MSKKVIEFLENYELLKGYTCLEESDFCYEFKVNLKDLLEEAGIEDSYVDFLDVKV
>NC_000918.1|WP_010881147.1|1245527_1246301_+|ribonuclease-HIII
MPSLKISPSEAEKIQNYLVSSGFRKINAPYTLWALEGNGVKVYYYKTGSLLIQGKNSEKVLKEVLNLLEKKKLPGCDESGKGDIFGSLVLCCVCIPEENYLKVSSLNPRDTKRLSDKRVERLYLALKPLVKAYCYEIKPEEYNKLYRKFRNLNKMMTHFYKLLIERVKEECGVSEVVVDKYQPSNPFGEDVIFETEAERNLAVAVASIFARYKFLQSLKEVERELGIKIPKGTSKEVKELAKSLKNPERFIKLNFNV
>NC_000918.1|WP_164930762.1|1245233_1245518_+|30S-ribosomal-protein-S20
MPNTRQAKKRMRRDAKRRLRNRYHLSRMRTYIKNFRRMIENGEIDKAKEYINEVISVIYHTAAKGVIHKNEAARRASRVYKLLNKALQQQQAQA
>NC_000918.1|WP_165438795.1|1243107_1245111_+|transketolase
MPQLFKTSKKIDELVINTIRFLSVDMVERAKSGHPGMPLGASHIVYLLYDRIMKYNPKNPNWFNRDRFILSAGHGSAMLYAAFYMFGFDLTLEDLKAFRQLNSKTPGHPEYGLTPGVEVTTGNLGQGFGNAVGMAMAEKFLSHYFNREGYPVIDHYTYVLVSDGDLMEGVSYEAASLAGHFKLNKLIAIWDNNHITIDGDTKLTWTEDVLKRFEALGWEVYHLEDGYNLDLLEETILKAKESDKPTFISVRTHIGYGTPLQDTPEVHGKPMGKEIVEETKKKFGWPLEEFYVPEEALNYTRRKVEEGKALEEEWNKLYAEYREKYPDLAQTLEKALNKEWSLDWLEKVEEFKEDMPTRKASGKVLNVMADYIPTMIGGSADLSESVNTVLKKYGDFEADTPTGRNVHYGVREHAMGTILNGMAYHGGILPYGGTFLIFSEYMRPAIRTAALANLQVIFVYSHDSIGLGEDGPTHQPVEQLWSLRSIPNLWVVRPADANEVKYAWEIALKRKNGPTAIILTRQKVKTIDRSKYASPEGVRKGAYVIADTEGKPDVVIIATGSEVQVALGAKEILEQKGIKTRVVNMACCELFEEQPEEYKREVLPPEVTKRVAVEAGRDTGWYKYVGSDGLVISLNEFGKSAPGSVLFEYYGFTPENVANKVIEKWFS
>NC_000918.1|WP_164930878.1|1241605_1242745_+|inositol-3-phosphate-synthase
MRENPKGRCENGRKKVRVAIAGVGNCASSFIQGIYYYKKKGTVDVSGLMHEDIGGYKPWDIEIVAAWDIDARKVGKDVSEAIFAPPNCTAVFEPDVPHMGVKVRMGKVLDGFAPHMKEYPPERTFVLADEKEDELEDVVAVLKETQADVLINYVPVGAEQAARFYAEACLRAGVSFINAMPTFIVSDPEWAKKFEEAGIPVVGDDIKSQVGATIVHRVLTQLFVDRGVKLDRTYQLNFGGNTDFLNMLARERLKTKKISKTEAVTSLLPYDLGWENVHIGPSDWVPWLNDRKIAYIRMEGRLFGDVPMYIELKLDVEDSPNSAGSMIDAVRCAKLARDRGVAGPLYSISAYTMKHPPIQYPDWQAKKMVEEFIRGERER
>NC_000918.1|WP_024015107.1|1241053_1241488_-|hypothetical-protein
MLPRDLIDLMRDLNVFPVVVSTVDGEGNPHLAFITWVYPTDERTIRIAVSSNAKTAQNIRQNSKVAIQIFAPDKALSCYGVGKEIKEKIEDVPFPVSVFEVQIDEVENSLFPGATITGIIPFAHTGNVLKMTELDSKVLKALKE
>NC_000918.1|WP_010881143.1|1239006_1241043_-|primosomal-protein-N'
MLVKVAISSGRTYLLECEDCPKNPIGYRVLFKGKSGKGSTGIIVGLSEGKAQGRVSSLPDKLPLVNTKALEIAKDLGNYYLDIPWKILWSFIPASFDWYEENFVLLAPRNLKNLDKNSLQVVEYIKKRRKVPYETLLERFDYRLIHLLKDHGIILKKTEWVIPRVEEEVYSLNIPLEEALKRVRSKEKKELIEFINEREKVTKEELLEQGFKSSHINDLLKRGILKREILYPKALSEIPLKQAPPLVKRKKGNEYLSTSFKRALDFLINLVAQNLGGGKNTLVLFPSKEELYRVSDELRNYFGEKVVEISARIKPKELYENWFRAHESGFVFLGSFKSVFLPFSELESVVLFNEQENTKFPANGVDLRRIAYLLSQKYASELIFTSPYPRLESFLLIKKGIFKHRKEDFKANIYIHERKGEVITEETYKFINDRVEERTLFVVVKQGYSYAYCPRCESLAECPECGSLLTFSKEKGEIFCPRVKKHYGSKAFECPSCGGELQEMGFGLERAREVIKDFFSERENFSFTTNPKWFEEYENVVILNADTLLSVPNYRSRERFLNLVLKSLRVAKNSLVIQSALISEEDKSLILNKNFEELFERELKRRKEEFLPPFSRLVVVESEQEIDEFLKEKVSENFFKVYEEFREVYRYMLKFKLGRLPEELKELKGMKNVRIIFD
>NC_000918.1|WP_010881142.1|1238128_1238974_-|bacteriocin
MEFLQRDQAPLTAEEWEQIDKTAYEVFKSTVVCRKFMPVVGPFGAGHQVVSYDVLYGVEPGVCEVKPGQEYKVCEPVRTGERKHVPVPTLYKDFVISWRDLEHWRQFNLPVDTTGVAAAASSLAVAEDKLILFGNQEMGIEGFLTAKGTLREELSDWEKVGNAFQDVVKGISRLVEKGFYTNYYLIVNPKRYFLLNRIHDNTGLLELEQIKKVVKEVYQTPIIPEDIVLLVSASPANFDLAIALDVNVAFVETSNMNHTFRVMEMVVPRIKRPEAILIFSS
>NC_000918.1|WP_164930765.1|1249357_1250086_+|uroporphyrinogen-III-synthase
MKLSYKRVILTRELEDIKKDKPLFEREGFKVLELPLIQTKVLEFNLPDEEFDYIVFQSKKAVKIFLGKVNLKGNKKIVAVGKKTAEELEKLGYKADFIPENESAKGLIELFKRLPKGKVLIPRSKIGRTELIKFLKETSFEVFALDVYTTEYVFYTREELLEKLNKGDFIIFYSPSAVKAFFANLQMHKIPKDSLSLKFVAIGKTTKEELQKHSVKNVITSERPSTEDIVKKLKELARDLQK
>NC_000918.1|WP_010881151.1|1250093_1250942_+|UDP-3-O-[3-hydroxymyristoyl]-N-acetylglucosamine-deacetylase
MGLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFCFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQKLTRDLPHLPSVQAL
>NC_000918.1|WP_010881152.1|1250898_1251639_-|hypothetical-protein
MEKRELKVKTLSEVRDYEIPILKETVFDIFGGLPQAFIGISGEAGAGKTQTLMRLMADIAKREPVLVVLTEQSPHRWKAIFKKYDTNHENVRVVFKYYMDQDFIKELSQREERIIVIDSISGAVSEQKARQVAKDLRSLVEWKNKWLVGALQVRKEGVAGGEGVEHMIEVSYEITYFQLKPQNKWLYEKLKPFGYEVGDYVRLIRNTFDKVRGVQNTNLVVVDISKKNGILEFRELGRKEGEVNHE
>NC_000918.1|WP_010881153.1|1251716_1252013_+|50S-ribosomal-protein-L27
MASKASGGSTRNGRDSISKRLGVKRYDGQFVKAGNIIVRQRGTRIYPGKNVGMGSDYTLFALKDGYVYFETRRKKKFVSVLSPEEWEKVMAQKNGKVH
>NC_000918.1|WP_164930766.1|1252006_1254337_-|glutamine-synthetase-adenylyltransferase
MEKFGKPLEENGKEATATVIGLGKLGSEELNYYSDVDLMFIHSTDKGKAGNLSLNDFFQRLFQKVVKLLNAQTPEGVPYFVDLDLRPFGKSGPLSMPLRSAELYYESYGRIWERFALLRARYCAGDEELAQKFMKEVVRPFVFGPADYKLVEEIRLMKKRIEAEAKKKFIKGYNVKTGEGGIREVEFSVQSLVILLGSKTPILRESNTYRAIYKLMQKGVFSSEEAQKLEESYTFLRKLEHRIQLRECLQTQVLKESDKETFAKFLGFESKEEFEEKLKETRAFVKSVFSQILPEREEEELDELQEAVIMEDEESGTQILKQKGFKSTRQIFTLLSEPLYGSMNVHFTEKEKKLYIKLIPKLVNLALSSQNPDQSIKNFFKFFFNPTGRRVILSEHKREEFLEKLFTVFSVSDYLSHLVARNPDLVEDALTLYRDFPKFEDFKREFEKYRETLNLSPENLYRRFKTVWEVRIGLVYLLKEEDRYEKLKKLYISLSTLADFILSNLWKDITLEENTALLYALGKLGSRELNFNSDLDLVFAVKSLEEKEKVHEKAKELVRFLTAHTTEGYLYSVDFRLRPMGSKGELVPTFDFYKKYFEKEARTWERLAWTRARYITGNEEFKEEFERLIENFLFEKPWGEKEKREVYEMRMKLQSVAKRGRGVVDLKLGEGGIVDGEFLVQYLLIKEKIRETSMIRGFEVLMEKYPRLKEAYDSFMFLRLVETHLRLSKERGTSVLSEQDIPKVALSLGMKPEELKESIKEKMKKMREVFNEFLAQ
>NC_000918.1|WP_164930767.1|1254344_1254809_-|hypothetical-protein
MSTVPSSWLSSSRRFLKEPEKAFSYFEKLLENHPKPKTLLDYLNERRFILLLMILEQSQCLRKFLLKHPTEFQNTIPNLWYLRKEKEDYVKELKELISESDSDEKFSEKLAFYRHRELLRIFSKELLGTAPYEDILSEYSHLPDALVEVTYERL
>NC_000918.1|WP_010881155.1|1254810_1255521_-|hypothetical-protein
MSVKVGWDITHQEFTITDYYYFSILQREAEKAGIEIDEVNDWESLNKYDVIVFNYPEIPFTESEVKDVERWVWKDGKKVILAGYYKNEDRIADTCNTLARAFGMELNPDEVTDEVNNHNGDKYFVVTSKIRRYNKNDKNEVNVEKIVLACTASIKPIMPDTKIVARGEDTAKSNMGNYPLLIAEQIAPPSGGYFCLAGTCVFWDNYSITLYDNLNFSLNLLRHVPPSKGTKLTIGP
>NC_000918.1|WP_164930879.1|1255531_1256050_-|translation-initiation-factor-IF-3
MKEYRVNRQIRAKECRLIDENGQQIGIVPIEEALKIAEEKGLDLVEIAPQAKPPVCKIMDYGKFKYELKKKEREARKKQREHQIEVKDIRMKVRIDEHDLQVKLKHMREFLEEGDKVKVWLRFRGRENIYPELGKKLAERIINELSDIAEVEVQPKKEGNFMIFVLAPKRKK
>NC_000918.1|WP_164930768.1|1256068_1256464_-|hypothetical-protein
MDKIILSLYSGSLFTIVFIVSPVLLRTEKNKDLAGHFYGKILWNFYRIFLPVLLLYGLLFNFFEGVILFLGLGVNVFISKKLKEFKRKLGSIENLDFNHPDRVKFRKLSYTSLSVLFLNFMLSTTILYKNL
>NC_000918.1|WP_010881157.1|1256564_1257410_-|fumarate-hydratase
MREVHVNDIKEAVKEAIIEANCVLPREVRVAFQEALKREESPIGREVLTQILENAEIAQKEKMPYCQDTGVDVIFVFLGQDVHVVGGSLEDAINQGVREATEEGYLRASMVWDPVFERKNTKDNTPAIIHYEVVPGDRVKIVVAPKGAGSENTSRLAMLKPADGWEGVKKFILETVKFAGPNACPPFTVGVGIGGNFEYCAYLAKKALLRPVGKRHENPLIAKVEEELLEEINKIGWGPMGFGGTVTAVDVKVEMYPCHIASLPVAVNIQCHANRHAERVV

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Crispr_ID: NC_000918_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_000918_9

1379598-1379894

Orphan

Consensus_repeat	Method
GTTTCAACTCCACTACGGTACATTAGGAAC	CRISPRCasFinder
GTTTCAACTCCACTACGGTACATTAGGAAC	CRT
GTTCCTAATGTACCGTAGTGGAGTTGAAAC	PILER-CR

4 spacers

The CRISPR arrays of NC_000918_9

>merge|NC_000918|9|1379598-1379894|CRISPRCasFinder,CRT,PILER-CR
ATAGCTTCTTCCACACGGTACATTAGGAACAAAGAAAATCCAAGAAATGTCCACGCCCTCCGAAGTCAGTTTCAACTCCACTACGGTACATTAGGAACTTATTTAGCATTCAAAAAAGGAGTTCTTGTAAATACAGTTTCAACTCCACTACGGTACATTAGGAACAAGTGAGGAGATGGGAAAGACATGAGGAAATTCTACGTTTCAACTCCACTACGGTACATTAGGAACTGCTGGATTTCCCTTCCTTATTTTAATGTTCATTACGTTTCAACTCCACTACGGTACATTAGGAAC

>NC_000918|9|9|1379598-1379894|CRISPRCasFinder
ATAGCTTCTTCCACACGGTACATTAGGAAC	AAAGAAAATCCAAGAAATGTCCACGCCCTCCGAAGTCA
GTTTCAACTCCACTACGGTACATTAGGAAC	TTATTTAGCATTCAAAAAAGGAGTTCTTGTAAATACA
GTTTCAACTCCACTACGGTACATTAGGAAC	AAGTGAGGAGATGGGAAAGACATGAGGAAATTCTAC
GTTTCAACTCCACTACGGTACATTAGGAAC	TGCTGGATTTCCCTTCCTTATTTTAATGTTCATTAC
GTTTCAACTCCACTACGGTACATTAGGAAC

>NC_000918|9|5|1379598-1379894|CRT
ATAGCTTCTTCCACACGGTACATTAGGAAC	AAAGAAAATCCAAGAAATGTCCACGCCCTCCGAAGTCA
GTTTCAACTCCACTACGGTACATTAGGAAC	TTATTTAGCATTCAAAAAAGGAGTTCTTGTAAATACA
GTTTCAACTCCACTACGGTACATTAGGAAC	AAGTGAGGAGATGGGAAAGACATGAGGAAATTCTAC
GTTTCAACTCCACTACGGTACATTAGGAAC	TGCTGGATTTCCCTTCCTTATTTTAATGTTCATTAC
GTTTCAACTCCACTACGGTACATTAGGAAC

>NC_000918|9|5|1379666-1379894|PILER-CR
GTTTCAACTCCACTACGGTACATTAGGAAC	TTATTTAGCATTCAAAAAAGGAGTTCTTGTAAATACA
GTTTCAACTCCACTACGGTACATTAGGAAC	AAGTGAGGAGATGGGAAAGACATGAGGAAATTCTAC
GTTTCAACTCCACTACGGTACATTAGGAAC	TGCTGGATTTCCCTTCCTTATTTTAATGTTCATTAC
GTTTCAACTCCACTACGGTACATTAGGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_000918.1\|WP_010881281.1\|1381710_1383000_-\|RIP-metalloprotease-RseP	unknown	unknown	gnl\|CDD\|272878
NC_000918.1\|WP_010881288.1\|1389497_1390295_-\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234723
NC_000918.1\|WP_010881284.1\|1384010_1385735_+\|bifunctional-3'-5'-exonuclease/DNA-polymerase	unknown	unknown	gnl\|CDD\|237876
NC_000918.1\|WP_010881283.1\|1383387_1383993_-\|DUF1122-family-protein	unknown	unknown	gnl\|CDD\|226799
NC_000918.1\|WP_010881272.1\|1374063_1374528_+\|50S-ribosomal-protein-L19	unknown	unknown	gnl\|CDD\|376502
NC_000918.1\|WP_010881273.1\|1374520_1375111_+\|ribonuclease-HII	unknown	unknown	gnl\|CDD\|260003
NC_000918.1\|WP_010881282.1\|1382999_1383404_-\|YjbQ-family-protein	unknown	unknown	gnl\|CDD\|376651
NC_000918.1\|WP_010881280.1\|1380177_1381698_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NC_000918.1\|WP_010881279.1\|1379312_1379582_-\|flagellar-biosynthesis-protein-FliQ	unknown	unknown	gnl\|CDD\|130469
NC_000918.1\|WP_164930791.1\|1375107_1375881_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373144
NC_000918.1\|WP_010881275.1\|1376131_1377250_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|225314
NC_000918.1\|WP_010881270.1\|1372612_1373650_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319742
NC_000918.1\|WP_010881286.1\|1386623_1387808_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NC_000918.1\|WP_165438804.1\|1385730_1386363_+\|bifunctional-phosphoribosyl-AMP-cyclohydrolase/phosphoribosyl-ATP-diphosphatase-HisIE	unknown	unknown	gnl\|CDD\|235067
NC_000918.1\|WP_010881277.1\|1377794_1378562_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|223428
NC_000918.1\|WP_010881287.1\|1387804_1389505_-\|type-II/IV-secretion-system-protein	unknown	unknown	gnl\|CDD\|225363
NC_000918.1\|WP_164930790.1\|1373637_1374006_-\|RusA-family-crossover-junction-endodeoxyribonuclease	unknown	unknown	gnl\|CDD\|226936
NC_000918.1\|WP_164930793.1\|1386355_1386583_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NC_000918.1\|WP_010881278.1\|1378548_1379325_-\|flagellar-biosynthetic-protein-FliR	unknown	unknown	gnl\|CDD\|130467
NC_000918.1\|WP_164930792.1\|1377354_1377798_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_000918.1\|WP_010881281.1\|1381710_1383000_-\|RIP-metalloprotease-RseP	gnl\|CDD\|272878	TIGR00054, Putative_zinc_metalloprotease_slr1821, RIP metalloprotease RseP. Members of this nearly universal bacterial protein family are regulated intramembrane proteolysis (RIP) proteases. Older and synonymous gene symbols include yaeL in E. coli, mmpA in Caulobacter crescentus, etc. This family includes a region that hits the PDZ domain, found in a number of proteins targeted to the membrane by binding to a peptide ligand. The N-terminal region of this family contains a perfectly conserved motif HEXGH as found in a number of metalloproteinases, where the Glu is the active site and the His residues coordinate the metal cation. Membership in this family is determined by a match to the full length of the seed alignment; the model also detects fragments as well matches a number of members of the PEPTIDASE FAMILY S2C. The region of match appears not to overlap the active site domain. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.21246e-100
NC_000918.1\|WP_010881288.1\|1389497_1390295_-\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl\|CDD\|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	1.99181e-153
NC_000918.1\|WP_010881284.1\|1384010_1385735_+\|bifunctional-3'-5'-exonuclease/DNA-polymerase	gnl\|CDD\|237876	PRK14975, PRK14975, bifunctional 3'-5' exonuclease/DNA polymerase; Provisional.	0
NC_000918.1\|WP_010881283.1\|1383387_1383993_-\|DUF1122-family-protein	gnl\|CDD\|226799	COG4353, COG4353, Uncharacterized conserved protein [Function unknown].	7.4881e-82
NC_000918.1\|WP_010881272.1\|1374063_1374528_+\|50S-ribosomal-protein-L19	gnl\|CDD\|376502	pfam01245, Ribosomal_L19, Ribosomal protein L19.	1.80695e-60
NC_000918.1\|WP_010881273.1\|1374520_1375111_+\|ribonuclease-HII	gnl\|CDD\|260003	cd07182, RNase_HII_bacteria_HII_like, Bacterial Ribonuclease HII-like. This family includes mostly bacterial type 2 RNases H, with some eukaryotic members. Bacterial RNase HII has a role in primer removal based on its involvement in ribonucleotide-specific catalytic activity in the presence of RNA/DNA hybrid substrates. Several bacteria, such as Bacillus subtilis, have two different type II RNases H, RNases HII and HIII; double deletion of these leads to cellular lethality. It appears that type I and type II RNases H also have overlapping functions in cells, as over-expression of Escherichia coli RNase HII can complement an RNase HI deletion phenotype. In Leishmania mitochondria, of the four distinct RNase H genes (H1, HIIA, HIIB, HIIC), HIIC is essential for the survival of the parasite and thus can be a potential target for anti-leishmanial chemotherapy. Ribonuclease H (RNase H) is classified into two families, type I (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type II (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H endonucleolytically hydrolyzes an RNA strand when it is annealed to a complementary DNA strand in the presence of divalent cations, in DNA replication and repair.	1.73424e-91
NC_000918.1\|WP_010881282.1\|1382999_1383404_-\|YjbQ-family-protein	gnl\|CDD\|376651	pfam01894, UPF0047, Uncharacterized protein family UPF0047. This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.	2.77618e-60
NC_000918.1\|WP_010881280.1\|1380177_1381698_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NC_000918.1\|WP_010881279.1\|1379312_1379582_-\|flagellar-biosynthesis-protein-FliQ	gnl\|CDD\|130469	TIGR01402, Flagellar_biosynthetic_protein_FliQ, flagellar biosynthetic protein FliQ. This model describes FliQ, a protein involved in biosynthesis of bacterial flagella. A related family of proteins, excluded from this model, participates in bacterial type III protein secretion systems. [Cellular processes, Chemotaxis and motility].	6.85595e-29
NC_000918.1\|WP_164930791.1\|1375107_1375881_-\|hypothetical-protein	gnl\|CDD\|373144	pfam14582, Metallophos_3, Metallophosphoesterase, calcineurin superfamily. Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	1.83908e-132
NC_000918.1\|WP_010881275.1\|1376131_1377250_-\|radical-SAM-protein	gnl\|CDD\|225314	COG2516, COG2516, Biotin synthase-related enzyme [General function prediction only].	1.01136e-157
NC_000918.1\|WP_010881270.1\|1372612_1373650_+\|hypothetical-protein	gnl\|CDD\|319742	cd16443, LplA, lipoate-protein ligase. Lipoate-protein ligase A (LplA) catalyzes the formation of an amide linkage between free lipoic acid and a specific lysine residue of the lipoyl domain in lipoate dependent enzymes, similar to the biotinylation reaction mediated by biotinyl protein ligase (BPL). The two step reaction includes activation of exogenously supplied lipoic acid at the expense of ATP to lipoyl-AMP and then transfer to the epsilon-amino group of a specific lysine residue of the lipoyl domain of the target protein.	1.66335e-50
NC_000918.1\|WP_165438804.1\|1385730_1386363_+\|bifunctional-phosphoribosyl-AMP-cyclohydrolase/phosphoribosyl-ATP-diphosphatase-HisIE	gnl\|CDD\|235067	PRK02759, PRK02759, bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE.	2.12159e-102
NC_000918.1\|WP_010881277.1\|1377794_1378562_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|223428	COG0351, ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme metabolism].	1.67803e-122
NC_000918.1\|WP_010881287.1\|1387804_1389505_-\|type-II/IV-secretion-system-protein	gnl\|CDD\|225363	COG2804, PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion].	0
NC_000918.1\|WP_164930790.1\|1373637_1374006_-\|RusA-family-crossover-junction-endodeoxyribonuclease	gnl\|CDD\|226936	COG4570, Rus, Holliday junction resolvase [DNA replication, recombination, and repair].	1.71698e-34
NC_000918.1\|WP_164930793.1\|1386355_1386583_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.7661e-13
NC_000918.1\|WP_010881278.1\|1378548_1379325_-\|flagellar-biosynthetic-protein-FliR	gnl\|CDD\|130467	TIGR01400, Flagellar_biosynthetic_protein_FliR, flagellar biosynthetic protein FliR. This model recognizes the FliR protein of bacterial flagellar biosynthesis. It distinguishes FliR from the homologous proteins bacterial type III protein secretion systems, known by names such as YopT, EscT, and HrcT. [Cellular processes, Chemotaxis and motility].	2.74327e-52
NC_000918.1\|WP_010881286.1\|1386623_1387808_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0

>NC_000918.1|WP_010881279.1|1379312_1379582_-|flagellar-biosynthesis-protein-FliQ
MEQDLIVSLGQRALEMTLLLALPVLLSTFVVGLVVSIFQAATQIQEMTLSYIPKVITAFLVIFLLGGWMMRKLVDFAVEIFANIPVWIR
>NC_000918.1|WP_010881278.1|1378548_1379325_-|flagellar-biosynthetic-protein-FliR
MDKVTSEEFLITLLLSYFRIVSFLFTFPFYGSFLIPNTIRLYLAFALSFAVLSFINITPVKVNTFVEFLVYALNELLFGFSAGLILRLLFDALIIAGELIALHTGLGFLQMFIPGMTQMSLFSGFFTLYGTLIFLSLGGGEFIILGLAESFKRLPVGSFNIFYLNPEVFLNFFYESFRLGVKIAMPLILTALILNLVLAVVNRFIPQMNVFMVGLPLQVSIGLIILLLSLPLITITMSNHFQDFFKVFEYFIQSFKSP
>NC_000918.1|WP_010881277.1|1377794_1378562_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MIALSIAGFDNSGGAGTLADIRTFKHFGIYGVAVITALAVQNTQKVYEVFPIPPDVVKEELKAIFEDFPIKGVKIGMLANKEIAEVVYETLKSKKTNFIVLDPVFRSKSGRELLSEEGVEFLKSEFIKIVDLITPNVPEAEILCGEEIKSLEDVKNCAQKIYSLGAKSVLIKGGHLKGNYAIDILYDGKSFYEFKAPKIAGKTPRGTGCVYSSAILANYLRHKDLIKAIKTAKDFITEAIKNSKKLGKGYEIMDF
>NC_000918.1|WP_164930792.1|1377354_1377798_+|hypothetical-protein
MHALLLLLLSFTFALEPLSEWWSKAKEVCLYGKYKNYDGTLRDIKPFCCKVERVEVEPIKGLLKGKFGLKESLKVIASCNGAFYGVMSYDGTILAVGGKKGIVKETPSGVMEVEDEKTIHFVVCRSGASLEGCYGEVFAEGYIIKKK
>NC_000918.1|WP_010881275.1|1376131_1377250_-|radical-SAM-protein
MNKLVLEKLTEQKESPEYMQISWAAAMTLGLIPGQFYRDTKLSCINTLLTYPSGCHATCAYCGLQKAREIEYSKKNFIRVEWPTVKTDEIIERTKQVGHAERLCISQITHPRAIRDTKYILEKVHRELGDKIFISILLNATGHTYEDLEDYKRLGAETLTVALDAATPELFEKLRGRPMNSPHRWETYWKVLEWCADIMGDGHVGAHLIVGLGETEEEMVRTIQRVRDLGGRTHLFSFWPEEGSLMEKEKPCPAPQYRRVQMARYLIDNGLARYEDMKFNEKGQIIDWGVSKEVFEEIFWSGRPFMTAGCRGKTTEVACNRPFGDCSVSDIKSYPFRPNKNDLKRIRKQMFDYEMETHYPDILNPSSFRYAH
>NC_000918.1|WP_164930791.1|1375107_1375881_-|hypothetical-protein
MPRKVLAIKNFKERFDLLPKLKGVIAEKQPDILVVVGNILKNEALEKEYERAHLARREPNRKVIHENEHYIIETLDKFFREIGELGVKTFVVPGKNDAPLKIFLRAAYEAETAYPNIRVLHEGFAGWRGEFEVIGFGGLLTEHEFEEDFVLKYPRWYVEYILKFVNELKPRRLVTIFYTPPIGEFVDRTPEDPKHHGSAVVNTIIKSLNPEVAIVGHVGKGHELVGNTIVVNPGEFEEGRYAFLDLTQHKIKLEQFS
>NC_000918.1|WP_010881273.1|1374520_1375111_+|ribonuclease-HII
MLNYELELWEKGLLVAGVDEAGRGPLAGPVVAAAVILPPFTEPFIKGDSKKLTKKEREEAYEEIKNKALAVGTAVVDSAVIDRVNILRATKLAMKRALKDLKYHYDIVITDYVKLEGENCMPLVKGDEKSLNCACASIIAKVIRDKIMEIYHKIYPDFNFASNKGYPSKTHLEKVEKGEYTEIHRKSFSPLKKKLF
>NC_000918.1|WP_010881272.1|1374063_1374528_+|50S-ribosomal-protein-L19
MSSELLRKIEQKYLPKKEYPDFRVGYTVRVYYKIKEGDKERIQPFEGVVIRIRGSGAGKTFTVRRESFGVGIERTFPYYSPNIEKIEVVKIGKVRRAKLYYLRELKGKEAERKIKEIKQWEYEAMQRRKEEARKQREEEQKQAQEQAQEQEQNA
>NC_000918.1|WP_164930790.1|1373637_1374006_-|RusA-family-crossover-junction-endodeoxyribonuclease
MEEIELYLSKLPVPKSNRYIRPKGGKVFKPPRVTNWEARAIWELREQFKGDAIDYEISVDITLILPNRRKRDIDNMLKSLWDVMEKAGVIKNDNLIFEVHTVKKIEKGKEGVIIKIRPFQSP
>NC_000918.1|WP_010881270.1|1372612_1373650_+|hypothetical-protein
MKIYRAGKLDNLRSITLFHAMARLGYEGLIITTPVETYASVGYFDKTQEILDLEKCKKLGIPVIRREVGGGAVLLHENQVFYQLILKKSRAPFKVIDAYKKFSQPVINVYRRLGVEVEYRPINDLVVKRNKKKISGQGAADIEDSFVFVGGILLKFNTKLMAEIFRIPEEKFRDKVHKSLEENVTWVERETGRLPSYEEVEEFLVEEFSKVIPFEGEEPVPEEAIELADKLKEEFTSEEVLLEDTGRKHRAIKLREGVYLRTAVHKAQGGLIRTEVYTDGEVIERVKIYGDFTLYPKESLKELEEKLKGIKFEPEEIKKVAHEFLQKVDMPGVSAEDLVIAIYGD
>NC_000918.1|WP_010881280.1|1380177_1381698_-|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MRAIISVYRKEGIDKLAKALQELGYEIVSTGGTAKYLREKGISVKEVSEITGFPEILEGRVKTLHPVVHGGILFRDWVEKDKEEIEKHGIKPIDVVVVNLYPFEEKLKEGLTDKDLMEFIDIGGPTLIRAAAKNFFRVVILVDPEDYDWVIEKLKKGNLTLQDRAYLAWKAFSHTAYYDGVISQAFKKLYSIDTFGKEEALPLKRMQKLRYGENPHQRGFLYENPLEDIGITKAQVLQGKEMSFNNYLDADSAVRLVAEFPNQTVCAIIKHNNPCGVALGSSVKEAFLRAKEADPVSAFGGIVAFNDKVDGETAKELTSMFLEVVIAPDYDEEALRELSRKKNLRVIRFFGFQHAFDVKKVSGGYLLQDEDTVLYEKLQVVTKREPTAEEMEDLLFAWKVVKHTKSNAVVIAKNGQTLGIGSGNVSRVDSLKCAINKAKEFGFDLKGAVVASEAFFPFRDSIDIMAKEGITAVIQPGGSIRDQEVIDACNEHGIAMIFTGLRHFKH
>NC_000918.1|WP_010881281.1|1381710_1383000_-|RIP-metalloprotease-RseP
MGLIAFLILIGVLVWVHEFGHFLMAKLFRVKVEIFSIGFGPPIFRRQWGETVYQIAALPLGGYVKLYGEEENVHDPRAFSTKKPWQKILIALGGPLFNFLFTILVFALVYTAGVEVPKYLKEPVVVGYVQRDSIAQKIGIKPGDKIIKINGYEVRTWEDLRDALIRLSLDGVKETTLFLERNGEVLHLTIKVPNVQKGEELGIAPLVKPVVGGVKKGSPADQVGIKPGDLILEVNGKKINTWYELVEEVRKSQGKAIKLKILRNGKMIEKELIPAKDPKTGTYFIGLFPKTETVVEKKPFGEALASAVNRTWELTVLTLKTIAGLITGKVSFQTLGGPIAIAQIAGQAAQSGFIPYLVMMAFISLQLGIFNLIPLPILDGGLILLFAIEWLRGRPLPEKFKEYWQRVGLAIIITLTIFVFINDILRLLR
>NC_000918.1|WP_010881282.1|1382999_1383404_-|YjbQ-family-protein
MKEVLRVRTTKHTSIVNITQQVDQVVKKSGVREGICVVYTPHTTACVFVNEGADPDVVRDIVYSLEKLIPWNDPSYAHMEGNSAAHIRSAIIGNSRVIPIIDGELALGTWESIFLADFDGPRERKVIVVVLGEK
>NC_000918.1|WP_010881283.1|1383387_1383993_-|DUF1122-family-protein
MVKYEELLKTLENGINSEEGEIRLVRKSQGRFKEEFNFDLSLGSKPLLTLKVFLGRKPYWQPWVEVFGVNPNLRNVFFGSEAERKLYEFLSEHFGRIFVEYFEDKETTYELQKGVPPALSRLGFELLKLGYTYFRDWYIPEGLMEGGHKIQAEKPKTEEAKKRHLENLKKEFEEFIGKCEDEGLIKKVKERYNFLEHEGSS
>NC_000918.1|WP_010881284.1|1384010_1385735_+|bifunctional-3'-5'-exonuclease/DNA-polymerase
MDFEYVTGEEGLKKAIKRLENSPYLYLDTETTGDRIRLVQIGDEENTYVIDLYEIQDIEPLRKLINERGIVGHNLKFDLKYLYRYGIFPSATFDTMIASYLLGYERHSLNHIVSNLLGYSMDKSYQTSDWGASVLSDAQLKYAANDVIVLRELFPKMRDMLNELDAERGEELLKTRTAKIFDLKSPVAIVEMAFVREVAKLEINGFPVDVEELTNKLKAVERETQKRIQEFYIKYRVDPLSPKQLASLLTKKFKLNLPKTPKGNVSTDDKALTSYQDVEPVKLVLEIRKLKKIADKLKELKEHLKNGRVYPEFKQIGAVTGRMSSAHPNIQNIHRDMRGIFKAEEGNTFVISDFSQIELRIAAEYVKDPLMLDAFKKGKDMHRYTASVVLGKKEEEITKEERQLAKAINFGLIYGISAKGLAEYAKLGYGVEISLEEAQVLRERFFKNFKAFKEWHDRVKKELKEKGEVKGHTLLGRRFSANTFNDAVNYPIQGTGADLLKLAVLLFDANLQKKGIDAKLVNLVHDEIVVECEKEKAEEVKEILEKSMKTAGKIILKEVPVEVESVINERWTKD
>NC_000918.1|WP_165438804.1|1385730_1386363_+|bifunctional-phosphoribosyl-AMP-cyclohydrolase/phosphoribosyl-ATP-diphosphatase-HisIE
MNIILMLKLKFNEEGLIPVIAQDYRTGEVRMLAYANEEAIKKTLETGYAHYYSRSRKKIWKKGETSGELQKVIEVRVDCDEDALIYVIEQEKDRACHTGERNCFFRDIEGNKVEKPLPFEVLPRLQDVIREKIERKEENSYTAKLVSQGKERVFQKFGEEAVETLIALMKGEKEEVIYESADMLYTFLVSLSVSGIDIKEVMEELIRRFK
>NC_000918.1|WP_164930793.1|1386355_1386583_-|helix-turn-helix-domain-containing-protein
MIGVGERIRKIREERGMSLEEFAKAIGISTKKLEEIEKGISRPCDATLVFIAKRFNVDYRWLALGERAKEPAGVT
>NC_000918.1|WP_010881286.1|1386623_1387808_+|pyridoxal-phosphate-dependent-aminotransferase
MRKGLASRVSHLKPSPTLTITAKAKELRAKGVDVIGFGAGEPDFDTPDFIKEACIRALREGKTKYAPSAGIPELREAIAEKLLKENKVEYKPSEIVVSAGAKMVLFLIFMAILDEGDEVLLPSPYWVTYPEQIRFFGGVPVEVPLKKEKGFQLSLEDVKEKVTERTKAIVINSPNNPTGAVYEEEELKKIAEFCVERGIFIISDECYEYFVYGDAKFVSPASFSDEVKNITFTVNAFSKSYSMTGWRIGYVACPEEYAKVIASLNSQSVSNVTTFAQYGALEALKNPKSKDFVNEMRNAFERRRDTAVEELSKIPGMDVVKPEGAFYIFPDFSAYAEKLGGDVKLSEFLLEKAKVAVVPGSAFGAPGFLRLSYALSEERLVEGIRRIKKALEEI
>NC_000918.1|WP_010881287.1|1387804_1389505_-|type-II/IV-secretion-system-protein
MDKERIEKLLTLFAKAGYIKDGDIKKVLSEIQKDEDPIEALIRLGLITEDQLTEFFKQHIPSRVVEEINTSEIPAEVLNIVPRNLIEKYKVIPFKVENNKLFIYTFDPYNQDMLNELRFITKMHVIPFYAPPSVINKALDELFPKVTEILEEIPAEEIVIEKVDEEVSLDEALKSADAAPVVKLANLIIYEAVRRDASDIHIEPQEKVLRVRFRIDGVLRIFKEFPPVIKDGLITRIKIMANMDISERRKPQDGRIRVNVSGKKIDLRVNTVPTVYGEKVVMRIQEAEKYLKVKLEDLGFEPDDLEKYRRAIWKPWGMILVSGPTGSGKTTTLYASLMERNTPDVNIMTVEDPVEVSIPGINQVQVNEKIGLTFANVLRAFLRQDPDIILVGEIRDSETAEIAIRASLTGHLVFSTVHANDAPTTVTRLVDMGIESFLVGSSLILVVAQRLIRKLCPKCKEKADIPKDVLLRIGVIEDPSEEVVIYKAHEGGCEYCNYTGYKGRTAVHEILEVDDDIKELIIRGATHDVIRKKAIEKGMRTLYKNGLLKVKRGITSIEEVNRVLAV
>NC_000918.1|WP_010881288.1|1389497_1390295_-|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MAINLQTLFKKKREGKKITMVSTYDYWSAKLCDEVGIDCILVGDSLGTVVKGEGDTLSVTLEEIIYHTKCVMRGVKNAFVIADMPFMSYQVSMEKAVENCGRVIKETKAKAVKLEGGEEIAELVYKLTRIGIPVVGHVGFTPQHINVFGKPKVVGKKKEEEEKLRRDFRALEEAGAFMIVLESVPTHLAKELWKGSNSIVIGIGAGKYVDGQVLVFHDIVGLFEDFKPKFVRRYLEGAKLVKEALKNFKIDVEGGNFPSEEESYG

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Crispr_ID: NC_000918_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_000918_10

1418894-1419060

Orphan

Consensus_repeat	Method
TGCAAGGTTCCTAATGTACCGT-GTGGAGTTGAAAC	PILER-CR
GTTCCTAATGTACCGTGTGGAGTTGAAAC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_000918_10

>merge|NC_000918|10|1418894-1419060|PILER-CR,CRISPRCasFinder
TGCAGGGTTCCTAATGTACCGTGTGGAGTTGAAACCATAATAGGAGAATTTAGGAATGCTGATATGCGGGAGTTCCTAATGTACCGTGTGGAGTTGAAACTTGTCGAGAATTACATCGTCAGGAGTTTCTACTTCAAGGTTCCTAATGTACCGTGTGGAGTTGAAAC

>NC_000918|10|6|1418894-1419060|PILER-CR
TGCAGGGTTCCTAATGTACCGTGTGGAGTTGAAAC	CATAATAGGAGAATTTAGGAATGCTGATATGCGGGA
GTTCCTAATGTACCGTGTGGAGTTGAAACTTGTCG	AGAATTACATCGTCAGGAGTTTCTACTTCAAG
GTTCCTAATGTACCGTGTGGAGTTGAAAC

>NC_000918|10|10|1418900-1419060|CRISPRCasFinder
GTTCCTAATGTACCGTGTGGAGTTGAAAC	CATAATAGGAGAATTTAGGAATGCTGATATGCGGGA
GTTCCTAATGTACCGTGTGGAGTTGAAAC	TTGTCGAGAATTACATCGTCAGGAGTTTCTACTTCAAG
GTTCCTAATGTACCGTGTGGAGTTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_000918.1\|WP_010881318.1\|1416210_1417263_+\|flagellar-biosynthesis-protein-FlhB	unknown	unknown	gnl\|CDD\|129428
NC_000918.1\|WP_164930801.1\|1423817_1424114_+\|GYD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378038
NC_000918.1\|WP_164930798.1\|1410475_1410985_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224334
NC_000918.1\|WP_010881321.1\|1420126_1421089_+\|phosphate-ABC-transporter-permease-subunit-PstC	unknown	unknown	gnl\|CDD\|273992
NC_000918.1\|WP_164930797.1\|1409140_1409455_-\|hypothetical-protein	unknown	unknown	unknown
NC_000918.1\|WP_164930800.1\|1421932_1422364_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224334
NC_000918.1\|WP_010881320.1\|1419126_1420140_+\|phosphate-ABC-transporter-substrate-binding-protein-PstS	unknown	unknown	gnl\|CDD\|273374
NC_000918.1\|WP_010881326.1\|1425633_1426728_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NC_000918.1\|WP_010881325.1\|1424164_1425637_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|376340
NC_000918.1\|WP_010881310.1\|1407447_1408773_+\|flagellar-filament-capping-protein-FliD	unknown	unknown	gnl\|CDD\|224264
NC_000918.1\|WP_010881328.1\|1427259_1428528_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223551
NC_000918.1\|WP_010881317.1\|1415786_1416200_+\|YjbQ-family-protein	unknown	unknown	gnl\|CDD\|223509
NC_000918.1\|WP_010881311.1\|1408769_1409144_+\|flagellar-export-chaperone-FliS	unknown	unknown	gnl\|CDD\|224433
NC_000918.1\|WP_010881322.1\|1421067_1421925_+\|phosphate-ABC-transporter-permease-PstA	unknown	unknown	gnl\|CDD\|273373
NC_000918.1\|WP_010881316.1\|1412895_1415712_-\|AAA-domain-containing-protein	unknown	unknown	gnl\|CDD\|223786
NC_000918.1\|WP_164930802.1\|1426766_1427258_+\|cation:proton-antiporter-regulatory-subunit	unknown	unknown	gnl\|CDD\|223564
NC_000918.1\|WP_164930882.1\|1429089_1431501_+\|translation-initiation-factor-IF-2	unknown	unknown	gnl\|CDD\|235401
NC_000918.1\|WP_010881314.1\|1410985_1411810_-\|30S-ribosomal-protein-S2	unknown	unknown	gnl\|CDD\|235396
NC_000918.1\|WP_164930799.1\|1417253_1418558_-\|protoporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|213540
NC_000918.1\|WP_010881315.1\|1411901_1412879_-\|Hsp33-family-molecular-chaperone-HslO	unknown	unknown	gnl\|CDD\|238278

Protein	Function_ID	Function_description	E-value
NC_000918.1\|WP_010881318.1\|1416210_1417263_+\|flagellar-biosynthesis-protein-FlhB	gnl\|CDD\|129428	TIGR00328, Flagellar_biosynthetic_protein_FlhB, flagellar biosynthetic protein FlhB. FlhB and its functionally equivalent orthologs, from among a larger superfamily of proteins involved in type III protein export systems, are specifically involved in flagellar protein export. The seed members are restricted and the trusted cutoff is set high such that the proteins gathered by this model play roles specifically related to flagellar structures. Full-length homologs scoring below the trusted cutoff are involved in peptide export but not necessarily in the creation of flagella. [Cellular processes, Chemotaxis and motility].	4.95551e-158
NC_000918.1\|WP_164930801.1\|1423817_1424114_+\|GYD-domain-containing-protein	gnl\|CDD\|378038	pfam08734, GYD, GYD domain. This protein is found in a range of bacteria. It is usually less than 100 amino acids in length. The function of the protein is unknown. It may belong to the dimeric alpha/beta barrel superfamily.	3.81059e-33
NC_000918.1\|WP_164930798.1\|1410475_1410985_+\|hypothetical-protein	gnl\|CDD\|224334	COG1416, COG1416, Uncharacterized conserved protein [Function unknown].	8.9169e-15
NC_000918.1\|WP_010881321.1\|1420126_1421089_+\|phosphate-ABC-transporter-permease-subunit-PstC	gnl\|CDD\|273992	TIGR02138, phosphate_transport_system_permease_protein_PstC, phosphate ABC transporter, permease protein PstC. The typical operon for the high affinity inorganic phosphate ABC transporter encodes an ATP-binding protein, a phosphate-binding protein, and two permease proteins. This family consists of one of the two permease proteins, PstC, which is homologous to PstA (TIGR00974). In the model bacterium Escherichia coli, this transport system is induced when the concentration of extrallular inorganic phosphate is low. A constitutive, lower affinity transporter operates otherwise. [Transport and binding proteins, Anions].	7.93386e-105
NC_000918.1\|WP_164930800.1\|1421932_1422364_+\|hypothetical-protein	gnl\|CDD\|224334	COG1416, COG1416, Uncharacterized conserved protein [Function unknown].	0.000421873
NC_000918.1\|WP_010881320.1\|1419126_1420140_+\|phosphate-ABC-transporter-substrate-binding-protein-PstS	gnl\|CDD\|273374	TIGR00975, precursor_PBP-3_PstS-3_Antigen_Ag88., phosphate ABC transporter, phosphate-binding protein. This family represents one type of (periplasmic, in Gram-negative bacteria) phosphate-binding protein found in phosphate ABC (ATP-binding cassette) transporters. This protein is accompanied, generally in the same operon, by an ATP binding protein and (usually) two permease proteins. [Transport and binding proteins, Anions].	1.32975e-131
NC_000918.1\|WP_010881326.1\|1425633_1426728_-\|HD-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	1.75554e-71
NC_000918.1\|WP_010881325.1\|1424164_1425637_+\|IMP-dehydrogenase	gnl\|CDD\|376340	pfam00478, IMPDH, IMP dehydrogenase / GMP reductase domain. This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.	0
NC_000918.1\|WP_010881310.1\|1407447_1408773_+\|flagellar-filament-capping-protein-FliD	gnl\|CDD\|224264	COG1345, FliD, Flagellar capping protein [Cell motility and secretion].	3.21076e-100
NC_000918.1\|WP_010881328.1\|1427259_1428528_+\|cation:proton-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	4.24018e-62
NC_000918.1\|WP_010881317.1\|1415786_1416200_+\|YjbQ-family-protein	gnl\|CDD\|223509	COG0432, COG0432, Uncharacterized conserved protein [Function unknown].	3.89316e-68
NC_000918.1\|WP_010881311.1\|1408769_1409144_+\|flagellar-export-chaperone-FliS	gnl\|CDD\|224433	COG1516, FliS, Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones].	2.02892e-37
NC_000918.1\|WP_010881322.1\|1421067_1421925_+\|phosphate-ABC-transporter-permease-PstA	gnl\|CDD\|273373	TIGR00974, 3a0107s02c, phosphate ABC transporter, permease protein PstA. This model describes PtsA, one of a pair of permease proteins in the ABC (high affinity) phosphate transporter. In a number of species, this permease is fused with the PtsC protein (TIGR02138). In the model bacterium Escherichia coli, this transport system is induced when the concentration of extrallular inorganic phosphate is low. A constitutive, lower affinity transporter operates otherwise. [Transport and binding proteins, Anions].	1.01787e-101
NC_000918.1\|WP_010881316.1\|1412895_1415712_-\|AAA-domain-containing-protein	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.00294e-31
NC_000918.1\|WP_164930802.1\|1426766_1427258_+\|cation:proton-antiporter-regulatory-subunit	gnl\|CDD\|223564	COG0490, COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism].	6.35915e-68
NC_000918.1\|WP_164930882.1\|1429089_1431501_+\|translation-initiation-factor-IF-2	gnl\|CDD\|235401	PRK05306, infB, translation initiation factor IF-2; Validated.	0
NC_000918.1\|WP_010881314.1\|1410985_1411810_-\|30S-ribosomal-protein-S2	gnl\|CDD\|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	5.32833e-162
NC_000918.1\|WP_164930799.1\|1417253_1418558_-\|protoporphyrinogen-oxidase	gnl\|CDD\|213540	TIGR00562, Protoporphyrinogen_oxidase, protoporphyrinogen oxidase. This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	0
NC_000918.1\|WP_010881315.1\|1411901_1412879_-\|Hsp33-family-molecular-chaperone-HslO	gnl\|CDD\|238278	cd00498, Hsp33, Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat shock), the Cys are reversibly oxidized to disulfide bonds, which causes the chaperone activity to be turned on. Hsp33 is homodimeric in its functional form.	6.63018e-117

>NC_000918.1|WP_164930799.1|1417253_1418558_-|protoporphyrinogen-oxidase
MREVVVIGAGISGLSTAYRLKKEGVDVVVYEKDDRIGGTIHTVKEKGYLFEVGAQTILADQEVIDFLKEAGIEPVEASPSSKYRYIYKKGRLIPLPMSPVEFLKTPLLSLKTKLKVLTEIFKRGVDEDISIADFVREHFGEEFLNYVVAPFISGVYAGDPEKLSLKHATPKLYEAQKKYGSLIKAFIKEKTAGPKGKLISFGEGLGELINALAQKLEVHTENVVLRMRKFEDFFRLDVRGKKVETKSVVVASPAYTSSYLLKEVSFSASEEFDKIDYPPVVVVNVGVEGKFPKVRLLSSESGKKRILGAMFMSKLFPGRAPQGKELLTVFLGGATDREVIELSEEEIENIVERELKEILQIDCIDFMHVQKWKRAIPQYTLGYDRFLNLAQEMEKDYPGLFLTGNWLYGVSTADCIRASKKVAQKVLSFLRPQA
>NC_000918.1|WP_010881318.1|1416210_1417263_+|flagellar-biosynthesis-protein-FlhB
MAEEHKTERATPYKRRKVREEGNVAKSHEIASSLVVLLSLLLLLFLGTYIAKEVILIFLAVTGYVHADISELGSLYENFYENIVKVLTPLFFLALLVVILSHVAQFGFIFTLKPLSFKWERINPFEGIKRLISLTTLFETVKNTLKAFLLIGIAVFVLKGSLYFFLSSSTYPLAETLKSFIKTSAITLITLGVVALLIAFLDYAFKRWQYEKKIMMSRRELKEEYKQLEGHPEVKSRIKARMRELAKSRMMAEVPKATVVITNPTHIAIALKYNPEKDKAPVVVAKGKGTIAQKIVEIAENYSIPVVRKPELARALYPAVEVGKEISPKFYKAVAEIIAYVMFKKKKVYA
>NC_000918.1|WP_010881317.1|1415786_1416200_+|YjbQ-family-protein
MKAYTKYLTFNTKKRRELIRITDEVKKAVEESEVKEGLCLVSSMHLTSSVIIQDDEEGLHEDIWEWLEKLAPYRPDYKHHRTGEDNGDAHLKNLLTHLQVVLPITNGKLDLGPWQEIFYAEFDGQRPKRVVIKIIGE
>NC_000918.1|WP_010881316.1|1412895_1415712_-|AAA-domain-containing-protein
MGILNKFLKKEERKEEKTPEFTVGDLKFKYFPLKRDPDAKIEEYWIETLDVSEDAYWVLVGRRHGIFQLYDWAGNLHRLPSKPPAQSITDIVFRGKYLGVVAPPYLVIYYLENSKDPKTWKSVRISQEGLRPTGGLDIRKGSLAFGVVGEKVYVIDLSGDLTQTTVDFKSTFIYRDAEIGDLRALKILPNGKLFLSGTQGCAVFSIGGNLLRKLNYAGNRAIALYEDKVFIADNEKQKIAIYDSALDRVEGELELPHRVGLIDVSPEGSFLFSADEEENRLGVYDLRNNQFLGFLEGYGYSVVRVASDGSVYTSRWEEQEGKLYYFLEKFETNLIDFLYPKERQKQIIKNANEIYKEFKKVLKEAKTEEELESVKPLRELEEISVPLKEVRELILKAREELQERKLEVFYENIKKKLQEGTITGQDYNRLKEKIEEVSQEWKEKLEELRKEVVEFFNKKLNEHLEKVREAISRAKVKSFSELESLQEVKETRKFISTLPREFYNYANEELLKTLQEKLIEDRLKTFTIKLLEDKVIFGREEVEKFKAEPVRYKWHVKVEDKFLQDGKVFARLIFEREDGLSVEPKRYNNILEQSEVGHFPPWVGRYLKHLNGLCSAEQYRVPEFVSFEETPWFVQNLERFTSLVKEQLQYHEGILILEGDAGVGKNFLVEVFSALTNRPLFIIPCNSKMEKEDITFIYEFDPKKGTKKVYSDLVRALRTPGAVIYLDEINTLPPSLVKIFNPLFDYRRYLVLSYGEVVKARPDVILVGGMNPQNYLGVSELPQDIKSRADIMYVDYPPFEDEKGFYYPDEALILKDYLDTLASLNKEEFTYLWYYVVNDVKTQLGEKLRTPERERDVKLLFDLLKIANEIRKAYRAYQTQQSEEPVEFVFSIRDTIRCARRLRKYGDAKTVVMETIIPKISSPLEKEIVKSIIERAVG
>NC_000918.1|WP_010881315.1|1411901_1412879_-|Hsp33-family-molecular-chaperone-HslO
MLIKELSEQVKKDLKDYFQERDYMVIAVPKKEPVRVYVVKATNTVETARRIHNLSPSATVAMGRAIVGALLLTSLLKHGTNQKLLLKIEGDGPIGTIVVEADAKGRVRGFVGNPNVDTYTKEVEGKKKFDVAKIVGKGTLTVVKDLGMGKPYTSVVPLISGEIGQDIAYYLYQSEQTPSAVAVGVKVNEDGSVKHAGGYLVQTLGGTSEKVKELLEKRILSLPPVTEMMEKGMRPEDIAVEILKDMEPQLIGLKEVEYYCPCDEEVAKASLFLMSTQELEDLFNENELAEVSCNFCGRIYRFDRSVIEEKRELEKKKGENGEKKD
>NC_000918.1|WP_010881314.1|1410985_1411810_-|30S-ribosomal-protein-S2
MPVVSMKELLEAGVHFGHSKSRWNPKMAPYIYGVRHGIHIIDLNKTIVMLEDAYHFVSDVIAQGGEILFVGTKKQAKDIIKEEAERCGAFYVNERWVGGLLTNFQTVRKSIMKLQTLERMEEDGIFDVLPKKEVRNLRRKMEKLRKLYNGIRDMKKLPDVIWIVDTVREKIAVSEARKLGIPIVAIADSNCDPTVIDYTIPGNDDAIKSIKLLTSKIADAVLEGKQRRESAEEVVPTKERRPVEITERERQLFEQAVEMSEKYAELDKDSTEYE
>NC_000918.1|WP_164930798.1|1410475_1410985_+|hypothetical-protein
MKKLVLLFMFFSFLFAEEHAKFVQTPYEAPFKVVVEFYFDEPEKIRPALLWVSNIIYVLSNEPYNFVPGEDIDIVVIIHGTEITTLVKKNREKYKDIWERIEGMSMYGVKFKVCAMAAEQLYGYSKEDFPPFVDLVPSAITELLHWQQKGYALLIPQIYEMKRTREEIR
>NC_000918.1|WP_164930797.1|1409140_1409455_-|hypothetical-protein
MEALEEVAKFTEEYLKPYCKKLEVKKELNKYLFFCGNYLLGSTVQIDEDKVATTVYSARAGDKILMEFLKAVKEKFNGRVKEQGIKFSHALNEDFYYAYNHIEV
>NC_000918.1|WP_010881311.1|1408769_1409144_+|flagellar-export-chaperone-FliS
MRNIAEAYFQNMVETATPLEQIILLYDKAIECLERAIEIYDQVNELEKRKEFVENIDRVYDIISALKSFLDHEKGKEIAKNLDTIYTIILNTLVKVDKTKEELQKILEILKDLREAWEEVKKKV
>NC_000918.1|WP_010881310.1|1407447_1408773_+|flagellar-filament-capping-protein-FliD
MAGELYFSGVTGAYDWGSVLDNIMAVKSIPIQKLQQKKQLINQKLQILGEFSQKLSDLKNLIENFNLESALKTKKADVSDSDVISVSVSENAPEISFSVNVLNTASKEILVYDAGFNSLDETIGSDGSFTLRYYTSPTDYVEYTIDYSLIDTLKDIVNKINETQDYVKASIYYDGNKYKLMLAETSEENSTVETAPDLSTKAIHLLGTLPHQFGNNVLIQQAKNARIQIGSGDVIESAGNTFENVIEGVSISAKRAGTSEVSISQDFSKIREFLNNFVKSYNEVVSQVKSLTLGENAPFRGENTIMNVKYGLSDTLTPLMELGLIEYKEDGTISLSGNLESVINEKPDEFKLKMTQFLESAKAVAKVNYEAFEDFKEYLNDQAERIDENIRLLSQRLVQEEQILKRQFAQLEDFMNYANQIRERLKQFMVSISEMNGGNNK
>NC_000918.1|WP_010881320.1|1419126_1420140_+|phosphate-ABC-transporter-substrate-binding-protein-PstS
MNRKKFLLGVLALAIFPAAGIAKEKVINGAGATFPAPLYWKWADAYYKATGIKVNYQSIGSGGGVRQIVNRTVDFGASDAPLKPEETKKHNLAQFPTVIGGVTVAYNLRGVENLKLSTRAVCDIFLGKIKYWDDPVIKKDNPGVKLPHKRITVVRRSDGSGTTWIFTNYLSKACPEWKEKVGYGKAVRWPTGIGAKGNEGVANYIRRIKGAIGYVEYAYAIQNKIPVAAVENRDGKFVKPSIETFQAAAANAKWDPKKDFYEVLTWQPGEKAYPIAGATFILLAKDEDRKEINKEVVKFFDWAYKNGDKMAIELHYVPLPENVKNMIRNYWREHGWY
>NC_000918.1|WP_010881321.1|1420126_1421089_+|phosphate-ABC-transporter-permease-subunit-PstC
MDGINRRKDKVIDKLVFLSLGFFAFFLGLLYPLFVGVSLLKESWLAIQKFGVIGFITGTVWDPVQEIFGGLPAIVGTLITTFLASLIAIPVCIGIAIFIAELCPKPLKPVFTTAIELLGAIPSIIYGMWGFFIIAPLMADYVEPFLQETFIDVPVIGKLFDGAPTGIDVLTSSFVLSIMIIPFMASIVKDAFEMTPQLLKEAGYGMGATKWEVIKDVIIPYAFPGIVGGAVLSVGRALGETMAVAFLTGNVHQIPKSLFDQLTTITVAIANEFTEAHQDIYLSSLYYLALILFIMSFLLLILSKFLIFKRLEKRWKVTGI
>NC_000918.1|WP_010881322.1|1421067_1421925_+|phosphate-ABC-transporter-permease-PstA
MEGHGNLERYVKWRKFKSNLILFFTFLTALYGLVWLVWIITDVTIKGFSNLSLDLLLKDPTPPGVEGGGLKHAFVGHLIITSLAVVLGVPIGIAAGVFFTEYGRYSRFVSLLRDLTDSIVSLPSIIVGTFIYAVMVKPVGHFFALSGSVSLALLMLPVIAITTAQMLKMVPDSLREAAYALGAYKWQVIKDVSLSVAKRGILTGVILGIARITGETAPLLFTSFNNNFTTYNIFEPMASLTVTIFVYVMGPYDDWHRKAWAASLILTIGTLMFFILAKILVRAKK
>NC_000918.1|WP_164930800.1|1421932_1422364_+|hypothetical-protein
MKKFFLFLVLPIFLFASPLKAVFDCAVGDLDWISLRLSLIKKTAEQLMEEGKSYRFVITIHSHCIKVVDADLKKFPESERRKIELIQSQLKTLKEMYSVDVKACQIAMNRGKIKKVPPFVETVPNSWITLIELQNKGFAFVPF
>NC_000918.1|WP_164930801.1|1423817_1424114_+|GYD-domain-containing-protein
MPVFVILTTLTDEGAKTLKNKPERIKEVDEELCNKYGIKILAQYALMGPYDFLNVVEAPDNDTILKMAIELNSRGTIRTLTMPAFDIDTLIKDLKEQQ
>NC_000918.1|WP_010881325.1|1424164_1425637_+|IMP-dehydrogenase
MVEVEKKIKEGLTFDDVLLVPQYSEVLPHEVDVSTYLTKRIKLNIPIVSAAMDTVTEARLAIALAREGGIGIIHRNLPIKKQAEEVEKVKKSESGMIINPVTVKPDTRVKEALDIMAKYKISGVPVVDEERKLIGILTNRDLRFIKPEDYSKPVSEFMTKENLITAPEGITLDEAEEIFRKYKIEKLPIVDKEGKIKGLITIKDIVKRKKYPNACKDELGRLRVGAAVGTGEETLDRVAALVEAGVDVIVVDTAHGHSKRVLETVEKIKANFPEVDVIAGNVATAEGTKALIEAGADAVKVGVGPGSICTTRIVAGVGVPQLTAIMEAASAAREYDIPIIADGGIRYSGDIVKALAAGASAVMLGNLLAGTEEAPGETIYYQGRAYKVYRGMGSLGAMSSRLSSDRYGQEKMEKFVPEGIEGRVPYKGKLADVVYQLVGGLRSGMGYVGARNIKELQEKAKFVRITWAGYRESHVHDVQITREAPNYWVD
>NC_000918.1|WP_010881326.1|1425633_1426728_-|HD-domain-containing-protein
MKLNAEFFIRLIGLRDAYTRGHTERGVFYAQLIGKELGLTSQEIELLKLGGYIHDVGKVAIPDVILLKPAKLTPEEYEIMKLHVELGYEMVKDLEIPWESLEVLLYHQEKYDGTGYPFGKKGEEIPLLARIYTIADSFEAMTTRRIYKRAKSWNEALKELEELAGKQFDPDIVPYAVRALSRIRALPLGENNCPLEIEKIRWSFYYLDSITGAVKGDLFLPTLRAFIEKGEPFCLTLFDIYNLLEFNRKHGWEEGNRVLKKLVEAINIQCCSAVDVKDVIIKLMKQDILDLTSSVIFRIGGDEFAVIAPYIPPQEKVINVVRTMEEHGVKIKFFQMQFPYTFTKYEEVLEVLRNFMKKEGKKGI
>NC_000918.1|WP_164930802.1|1426766_1427258_+|cation:proton-antiporter-regulatory-subunit
MKIKETELPGVGKKYTIELEEGGELTLIIHNTGRRELYLVEEEEEEPSCVFSLTEEEARELGFLLAGTTFQTVSTERMELLMKEIVMEWVKVGENSNFIGKTIADLEIRRKTGVSIIAIIRDGEMIPSPDPYKEKIQAGDTLIVVGTREQLIKFLEMCGDCST
>NC_000918.1|WP_010881328.1|1427259_1428528_+|cation:proton-antiporter
MEHHLHHIIQETAPYLVLLFMFIFGYTFQKVNIPSIIAFMIIGFLAQPLVPPEKIKDFEIFKHAGIILLFFFIGLEYSFERLRTMLGAWKTGSIDFVFNFIPPFIIAYAFGFDLITALILAAVFYPSSTSIIAKLLMDYKRIASPEAELLIGILIFEDLVAILLLTIIIPLKEAGSIEFTTIPVSLVKLGVAFLLFWLIYKYLIPKINAWLDRVSEEDIFIFFTLGLVLSIGTIFHSLGISEALGAFLLGVIVPETKVLENIEKQLSDLKELSMGLFFFFFAYETQLTKPENLGLLILLIVLGIILKIISTYLAGYVFGLKKKSRLRASLSFVPRGEFSVIMTSFEPALKSTSIPFIFLTAVIGSILFALAPKVADIIYPPKKKKKKKPIKRPKKGYLKRSRAFSEHAPSLQSSRPETPPQQ
>NC_000918.1|WP_164930882.1|1429089_1431501_+|translation-initiation-factor-IF-2
MTKTKRVSDVAKELGVKSKEIIEFLNEYYPRPDGKPWKASHGLDEQALEMIYDAFGIKEEEEKEEVVTEQAQAPAEVEEKKEEEKKEEVIVEEVVEEKKPEVIVEEIEEKKEEEEKKEEEKPKKSVEELIKEILEKKEKEKEKKKVEKERKEEKVRVVEVKKEERKEEKKEEKKEEEKPKIKMSKKEREIMRKLEHAVEKEKKKQEKREKEKKKKEEEVKIIYIPEVITVRELAELLDVPANKVIAELMKRGVLATINQPVPPEVAVEVAESFGYLAEVKKEEEELEEEALLKEEEEREEELQPRPPIVVVMGHVDHGKTTLLDRIRKTNVAEREKGGITQHIGASQVELPDGRKITFLDTPGHEAFTTLRARGAKVTDISVLVVAADDGVMPQTIEAINHAKAFNVPIIVAVNKIDKPNADPMKVRRELSEHGLIPEEWGGDTIFVDISAKTGQNVDQLLEMILLLADILELKANPNKKARGTIIESKLDRKRGPVATVIVEDGTLRVGDHFVAGTTYGRVRAMFDDKGRQVKEAPPSTPVEVLGFEELPEAGDELIVVDDERTAREIAEKRKEKKEREEKLQTIRLEDIYKKIQTGETKELRIVLKTDTMGSLEALKKSLEELSNEKVQVKIIHGAVGGITENDIMLAKASGAIVIGFNTRPDPKARELMEKEKVDVRLYGVIYEAIEDVKKALVGLLEPIKKEEVIGMAEVRATFKIKKVGTVAGCYVLNGKLVRGAKARLIREGVVIYDGEIESLKRFKEDVQEVTAGYECGVKLKDYNDVKVGDQIECYEIRYEKPTL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	MK448461	Streptococcus satellite phage Javan378, complete genome	3229-3259	5	0.839
NC_000918_5	5.2\|692159\|36\|NC_000918\|CRISPRCasFinder	692159-692194	36	MK257744	Thermus phage YS40_Isch, complete genome	55037-55072	7	0.806
NC_000918_8	8.1\|1249224\|30\|NC_000918\|CRISPRCasFinder	1249224-1249253	30	MF497422	Vibrio phage vB_VspS_VS-ABTNL-3, complete genome	17377-17406	7	0.767
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	NZ_CP017584	Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ03, complete sequence	10395-10425	7	0.774
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	NZ_CP045406	Roseovarius sp. THAF9 plasmid pTHAF9_b, complete sequence	117223-117253	7	0.774
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	MN693280	Marine virus AFVG_25M171, complete genome	1849-1879	7	0.774
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	MG945547	UNVERIFIED: Microviridae sp. isolate 2686-1602, complete genome	442-472	8	0.742
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	CP002962	Emticicia oligotrophica DSM 17448 plasmid pEMTOL01, complete sequence	70023-70053	8	0.742
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	CP002963	Emticicia oligotrophica DSM 17448 plasmid pEMTOL02, complete sequence	23613-23643	8	0.742
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	MN694578	Marine virus AFVG_250M492, complete genome	19811-19841	9	0.71
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	MN694658	Marine virus AFVG_250M284, complete genome	38298-38328	9	0.71
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	AP012539	Stx2-converting phage Stx2a_WGPS6 proviral DNA, complete genome	26479-26509	9	0.71
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	FM180578	Enterobacteria phage 2851, complete genome	25744-25774	9	0.71
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	AF548456	Enterobacteria phage LC159 DNA-binding protein Roi (roi), unknown, antitermination protein Q (Q), shiga toxin 2 subunit A (stxA2), and shiga toxin 2 B subunit (stxB2) genes, complete cds; and unknown genes	5643-5673	9	0.71
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	NC_049944	Stx2-converting phage Stx2a_WGPS8 proviral DNA, complete genome	23581-23611	9	0.71
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	AJ605767	Bacteriophage 2851 roi gene, ORF2, ORF3, Q gene, stx2A gene, stx2c B gene, ORF7, ORF8, ORF9, S gene, R gene (partial), tRNA-Ile gene, argN genes and argO gene	6183-6213	9	0.71
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	KU878088	Bacillus phage AR9, complete genome	248344-248374	10	0.677
NC_000918_8	8.2\|1249289\|31\|NC_000918\|CRISPRCasFinder	1249289-1249319	31	MF360957	Bacillus virus PBS1, complete genome	157862-157892	10	0.677

1. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to MK448461 (Streptococcus satellite phage Javan378, complete genome) position: , mismatch: 5, identity: 0.839

atgctgcaaaaa-caaaaaggaaaaagctgag	CRISPR spacer
-tactgaaaaaatcataaaggaaaaagctgaa	Protospacer
 *.*** ***** ** ***************.

2. spacer 5.2|692159|36|NC_000918|CRISPRCasFinder matches to MK257744 (Thermus phage YS40_Isch, complete genome) position: , mismatch: 7, identity: 0.806

ggtccaa-gttgttccatcagaagaaacagaaatggt	CRISPR spacer
-gtctaatattgctccatcagaagaaaaagaaatgaa	Protospacer
 ***.** .***.************** *******.

3. spacer 8.1|1249224|30|NC_000918|CRISPRCasFinder matches to MF497422 (Vibrio phage vB_VspS_VS-ABTNL-3, complete genome) position: , mismatch: 7, identity: 0.767

gagctaaagcaaccgcaccgatggttatga	CRISPR spacer
ctgctaaagcaactgcacctatggtgaagg	Protospacer
  ***********.***** ***** * *.

4. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to NZ_CP017584 (Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ03, complete sequence) position: , mismatch: 7, identity: 0.774

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
gtgctgaaaaaacaaacaggaaaaatcctaa	Protospacer
.***** ********* ******** *. *.

5. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to NZ_CP045406 (Roseovarius sp. THAF9 plasmid pTHAF9_b, complete sequence) position: , mismatch: 7, identity: 0.774

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
atcatcgaaaatcaaaaaggagaaagctgat	Protospacer
**  *  **** *********.********

6. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to MN693280 (Marine virus AFVG_25M171, complete genome) position: , mismatch: 7, identity: 0.774

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
aaaatcctaagacaaaaaggaaaaagatgag	Protospacer
* . * * **.*************** ****

7. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to MG945547 (UNVERIFIED: Microviridae sp. isolate 2686-1602, complete genome) position: , mismatch: 8, identity: 0.742

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
atgctgaaaaaacaaaaaggaaaggatacaa	Protospacer
****** ****************....  *.

8. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to CP002962 (Emticicia oligotrophica DSM 17448 plasmid pEMTOL01, complete sequence) position: , mismatch: 8, identity: 0.742

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
tgtctgcaaaaactaaaaagaaaaagattat	Protospacer
   ********** ****.******* * *

9. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to CP002963 (Emticicia oligotrophica DSM 17448 plasmid pEMTOL02, complete sequence) position: , mismatch: 8, identity: 0.742

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
tgtctgcaaaaactaaaaagaaaaagattat	Protospacer
   ********** ****.******* * *

10. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to MN694578 (Marine virus AFVG_250M492, complete genome) position: , mismatch: 9, identity: 0.71

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
cagctgcaaaaacaaaaagtaaaacaaacac	Protospacer
  ***************** **** .   *

11. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to MN694658 (Marine virus AFVG_250M284, complete genome) position: , mismatch: 9, identity: 0.71

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
tcttggaaaaaacaaaaaggaagaagatgaa	Protospacer
 . . * ***************.*** ***.

12. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to AP012539 (Stx2-converting phage Stx2a_WGPS6 proviral DNA, complete genome) position: , mismatch: 9, identity: 0.71

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
cagctacaaaaacaaaacggaaaaaaatatc	Protospacer
  ***.*********** *******. *.

13. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to FM180578 (Enterobacteria phage 2851, complete genome) position: , mismatch: 9, identity: 0.71

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
cagctacaaaaacaaaacggaaaaaaatatc	Protospacer
  ***.*********** *******. *.

14. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to AF548456 (Enterobacteria phage LC159 DNA-binding protein Roi (roi), unknown, antitermination protein Q (Q), shiga toxin 2 subunit A (stxA2), and shiga toxin 2 B subunit (stxB2) genes, complete cds; and unknown genes) position: , mismatch: 9, identity: 0.71

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
cagctacaaaaacaaaacggaaaaaaatatc	Protospacer
  ***.*********** *******. *.

15. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to NC_049944 (Stx2-converting phage Stx2a_WGPS8 proviral DNA, complete genome) position: , mismatch: 9, identity: 0.71

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
cagctacaaaaacaaaacggaaaaaaatatc	Protospacer
  ***.*********** *******. *.

16. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to AJ605767 (Bacteriophage 2851 roi gene, ORF2, ORF3, Q gene, stx2A gene, stx2c B gene, ORF7, ORF8, ORF9, S gene, R gene (partial), tRNA-Ile gene, argN genes and argO gene) position: , mismatch: 9, identity: 0.71

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
cagctacaaaaacaaaacggaaaaaaatatc	Protospacer
  ***.*********** *******. *.

17. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to KU878088 (Bacillus phage AR9, complete genome) position: , mismatch: 10, identity: 0.677

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
gactaagaaaaaagaaaaggaaaaagctgaa	Protospacer
.  . . ***** .****************.

18. spacer 8.2|1249289|31|NC_000918|CRISPRCasFinder matches to MF360957 (Bacillus virus PBS1, complete genome) position: , mismatch: 10, identity: 0.677

atgctgcaaaaacaaaaaggaaaaagctgag	CRISPR spacer
gactaagaaaaaagaaaaggaaaaagctgaa	Protospacer
.  . . ***** .****************.

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_001880

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_001880_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_001880_1

437-664

Unclear

Consensus_repeat	Method
CTTTCTATCCCATATATGGGAACTAAAAC	PILER-CR
CTTTCTATCCCATATATGGGAACTAAAACC	CRT

3 spacers

Cas14b_CAS-V-F

The CRISPR arrays of NC_001880_1

>merge|NC_001880|1|437-664|PILER-CR,CRT
CTTTCTATCCCATATATGGGAACTAAAACCTCAATAGCTTCTACTCCTTCAGGCACAGCTTCTTTCTTTCTATCCCATATATGGGAACTAAAACCAAAGAAGTCCTTTATCTTAGAAACCTTCTTTTTGGACCTTTCTATCCCATATATGGGAACTAAAACGGGAGTTCTAAAGAAGAGGTAATCGGGTATCTTTTCGCTTTCTATCCCATATATGGGAACTAAAACC

>NC_001880|1|1|437-663|PILER-CR
CTTTCTATCCCATATATGGGAACTAAAAC	CTCAATAGCTTCTACTCCTTCAGGCACAGCTTCTTT
CTTTCTATCCCATATATGGGAACTAAAAC	CAAAGAAGTCCTTTATCTTAGAAACCTTCTTTTTGGAC
CTTTCTATCCCATATATGGGAACTAAAAC	GGGAGTTCTAAAGAAGAGGTAATCGGGTATCTTTTCG
CTTTCTATCCCATATATGGGAACTAAAAC

>NC_001880|1|1|437-664|CRT
CTTTCTATCCCATATATGGGAACTAAAACC	TCAATAGCTTCTACTCCTTCAGGCACAGCTTCTTT
CTTTCTATCCCATATATGGGAACTAAAACC	AAAGAAGTCCTTTATCTTAGAAACCTTCTTTTTGGAC
CTTTCTATCCCATATATGGGAACTAAAACG	GGAGTTCTAAAGAAGAGGTAATCGGGTATCTTTTCG
CTTTCTATCCCATATATGGGAACTAAAACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_001880.1\|WP_164930892.1\|6831_7101_-\|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family	unknown	unknown	gnl\|CDD\|224937
NC_001880.1\|WP_010890549.1\|5876_6824_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271175
NC_001880.1\|WP_165438805.1\|90_432_-\|hypothetical-protein	unknown	unknown	unknown
NC_001880.1\|WP_010890547.1\|2253_3174_+\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	Cas14b_CAS-V-F	-	gnl\|CDD\|223747
NC_001880.1\|WP_010890548.1\|4110_5064_+\|hypothetical-protein	unknown	unknown	unknown
NC_001880.1\|WP_164930889.1\|3447_3669_+\|S-adenosylmethionine:tRNA-ribosyltransferase-isomerase	unknown	unknown	gnl\|CDD\|376813
NC_001880.1\|WP_010890546.1\|1710_2235_+\|hypothetical-protein	unknown	unknown	unknown
NC_001880.1\|WP_164930891.1\|5459_5702_+\|hypothetical-protein	unknown	unknown	unknown
NC_001880.1\|WP_010890545.1\|1139_1574_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|225266
NC_001880.1\|WP_164930888.1\|901_1150_+\|hypothetical-protein	unknown	unknown	unknown
NC_001880.1\|WP_164930890.1\|5114_5387_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_001880.1\|WP_164930892.1\|6831_7101_-\|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family	gnl\|CDD\|224937	COG2026, RelE, Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning].	9.92159e-19
NC_001880.1\|WP_010890545.1\|1139_1574_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|225266	COG2402, COG2402, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only].	6.37779e-35
NC_001880.1\|WP_010890547.1\|2253_3174_+\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.14428e-15
NC_001880.1\|WP_010890549.1\|5876_6824_+\|site-specific-integrase	gnl\|CDD\|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	2.1019e-15
NC_001880.1\|WP_164930889.1\|3447_3669_+\|S-adenosylmethionine:tRNA-ribosyltransferase-isomerase	gnl\|CDD\|376813	pfam02547, Queuosine_synth, Queuosine biosynthesis protein. Queuosine (Q) biosynthesis protein, or S-adenosylmethionine:tRNA -ribosyltransferase-isomerase, is required for the synthesis of the queuosine precursor (oQ). It catalyzes the transfer and isomerisation of the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to form epoxyqueuosine (oQ-tRNA). Q is a hypermodified nucleoside usually found at the first position of the anticodon of asparagine, aspartate, histidine, and tyrosine tRNAs. In Streptococcus gordonii, QueA has been shown to play a role in the regulation of arginine deiminase genes.	0.000336322

>NC_001880.1|WP_165438805.1|90_432_-|hypothetical-protein
MTRLKYKQIIDELDYLLKTFKALAQSSRVIIMKPKSEKSWTRVYYLEDLSWCVILGRGGIITSFRVEKDWFKDRLEFYREKLGYEPYGGSPSEELKRSAKRIYDVCRRFRERS
>NC_001880.1|WP_164930888.1|901_1150_+|hypothetical-protein
MKVRKNITLSKKAEEYLRMLAREKKKSQSEVIEELIEKEAKEYEKKKRLEAFERLVKNAKYYSGKIGNKTIQQIKEEMGSEL
>NC_001880.1|WP_010890545.1|1139_1574_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MNSEKVFVDGNVIVDIFDERRVNHKYSVQAIRILLANKFDLLTSSDLITTVYYVLSKIDKKKALSDIKEVVNILEIIPFGKAEVEKAIELMEGDKNFKDLEDTLQYVLAKKEGCKLILSNDKSFYSPDIEVLTTEEFCERWNTL
>NC_001880.1|WP_010890546.1|1710_2235_+|hypothetical-protein
MKVIKKTVLLKVYEPNKGKKECLDRVIDLYAKTLDFYLDVIKKAGIYRIVALARKKKERKSGRKSNYALNLLEKLTVPTQAHPNPLYPIPFSVRVDIRRSAINQAIGMVSSYVSNLKNWYEEGKELGHSKPSYPNPKSYSPQLYSTLVELDDLLVRENKEFHFVRIKVLNEKER
>NC_001880.1|WP_010890547.1|2253_3174_+|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MKVYKRLYELLGRGYKPLKSARLIKRGKDYYIGITLQKAVKEKKIKKPRYVINVDLNVQRNLACIGIFEVDWEKRESKLYGIKFVNGKLLRLVYKRDYLFEEIRKKQRQTGRSPQVGDNSRLWKKVNNLNRDIALKVAKEISDIAREFSEKGEVIVVFEKLKGLRGRKGRSKKLNRKINFWMRRKIQERVKELGLEEGFGLDFVYPHYTSKKCSKCGYEGERFSPSGSKALFLCKKCGYVVNADVNAVFNQHFLYLSHLLNGGGKARPVVRVGTSLKSPSREGHNLSGVPKATTTFFYISSLLSTF
>NC_001880.1|WP_164930889.1|3447_3669_+|S-adenosylmethionine:tRNA-ribosyltransferase-isomerase
MTVKQEDKLLSTPELLEELKKRGIDISRVTLYFWIKKGKIPKKFYTVKKRLERQFYYFKPELVEFLTQKLSSR
>NC_001880.1|WP_010890548.1|4110_5064_+|hypothetical-protein
MEHEKAIKEILGIDDRIRLYAIEKYEKKKKTFYRFTGWDTYKKKMVKVHIPRKLEKEIFSLWKEHQKEKQQLKALEQEVKALLEKYKDAEKIKEVLERIAQESITKTASSHALKTYTDKAKELFKKFEKDLINLYKEGVLKRLTILQVLYLLANLKEMSEEQKNPQFLFKKGISTIIKVAKNERIPNPFGTLKNDFFLSGTQTPYDFLLSSFLEEVLEETLRELLEKEIEKIEAERRAKEYEEKMEKIKEIVEWFESLPHKIKQTAKEVISQNTVEVAEKILKDMEDGNFSLKEVQDYLEKSTRENLVDYFRYLKNL
>NC_001880.1|WP_164930890.1|5114_5387_+|hypothetical-protein
MKAKDDFEKILFEEAEALEKILELLQKVRQKEIPTEKLCNLLEGVPKIKISPLSVDTKRATIVIQIEGEGRKLVAEKWNRIVRWEEDDTL
>NC_001880.1|WP_164930891.1|5459_5702_+|hypothetical-protein
MEDRKIEAIKERIRFYTEAFKTLLIISATLTGGIAGLLFKLNSPTSVFLIVVGLIIDVILISVAIKLYLNIEELFRRIEK
>NC_001880.1|WP_010890549.1|5876_6824_+|site-specific-integrase
MEHFIDTYLYELRKVRDEKTIKKKEYLLKHLQDYSEDLPAFDQSEIFSFYEYLKNKNLKETTIRDILKEVRLFYEWLQEQGLNLKFDEKALKKLFQSKKSQEALKSKKKYYSDDEINLILNAIRGAVEGISTKHPIYYILTIFLLCSGLRISEAVKVRKKDFEVKRILTEEGEEKEVWFVKVREGKFGKERKALIYFFRPEWKRIFEERLKKLKPEDFFFTYAVKYPKSVKVFTLTDKTAKWFYWKLEKELREKGYEIEVNAHRFRNTYITKLATKGFPVNLIADWVGHSKISTTMDVYMEAEREKQLEAILERI
>NC_001880.1|WP_164930892.1|6831_7101_-|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family
MSWTIKLSSTAERKYKKLDRNTRKRITKALEELSECEDPLMHKHVRPLVGKLKGFYRLRVGDYRVIFALIPEEKIIAVVNIAPRGEAYK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Identity
NC_001880_1	1.1\|466\|36\|NC_001880\|PILER-CR	466-501	36	NC_001880	Aquifex aeolicus VF5 plasmid ece1, complete sequence	466-501	1.0
NC_001880_1	1.2\|531\|38\|NC_001880\|PILER-CR	531-568	38	NC_001880	Aquifex aeolicus VF5 plasmid ece1, complete sequence	531-568	1.0
NC_001880_1	1.3\|598\|37\|NC_001880\|PILER-CR	598-634	37	NC_001880	Aquifex aeolicus VF5 plasmid ece1, complete sequence	598-634	1.0
NC_001880_1	1.4\|467\|35\|NC_001880\|CRT	467-501	35	NC_001880	Aquifex aeolicus VF5 plasmid ece1, complete sequence	467-501	1.0
NC_001880_1	1.5\|532\|37\|NC_001880\|CRT	532-568	37	NC_001880	Aquifex aeolicus VF5 plasmid ece1, complete sequence	532-568	1.0
NC_001880_1	1.6\|599\|36\|NC_001880\|CRT	599-634	36	NC_001880	Aquifex aeolicus VF5 plasmid ece1, complete sequence	599-634	1.0

1. spacer 1.1|466|36|NC_001880|PILER-CR matches to NC_001880 (Aquifex aeolicus VF5 plasmid ece1, complete sequence) position: , mismatch: 0, identity: 1.0

ctcaatagcttctactccttcaggcacagcttcttt	CRISPR spacer
ctcaatagcttctactccttcaggcacagcttcttt	Protospacer
************************************

2. spacer 1.2|531|38|NC_001880|PILER-CR matches to NC_001880 (Aquifex aeolicus VF5 plasmid ece1, complete sequence) position: , mismatch: 0, identity: 1.0

caaagaagtcctttatcttagaaaccttctttttggac	CRISPR spacer
caaagaagtcctttatcttagaaaccttctttttggac	Protospacer
**************************************

3. spacer 1.3|598|37|NC_001880|PILER-CR matches to NC_001880 (Aquifex aeolicus VF5 plasmid ece1, complete sequence) position: , mismatch: 0, identity: 1.0

gggagttctaaagaagaggtaatcgggtatcttttcg	CRISPR spacer
gggagttctaaagaagaggtaatcgggtatcttttcg	Protospacer
*************************************

4. spacer 1.4|467|35|NC_001880|CRT matches to NC_001880 (Aquifex aeolicus VF5 plasmid ece1, complete sequence) position: , mismatch: 0, identity: 1.0

tcaatagcttctactccttcaggcacagcttcttt	CRISPR spacer
tcaatagcttctactccttcaggcacagcttcttt	Protospacer
***********************************

5. spacer 1.5|532|37|NC_001880|CRT matches to NC_001880 (Aquifex aeolicus VF5 plasmid ece1, complete sequence) position: , mismatch: 0, identity: 1.0

aaagaagtcctttatcttagaaaccttctttttggac	CRISPR spacer
aaagaagtcctttatcttagaaaccttctttttggac	Protospacer
*************************************

6. spacer 1.6|599|36|NC_001880|CRT matches to NC_001880 (Aquifex aeolicus VF5 plasmid ece1, complete sequence) position: , mismatch: 0, identity: 1.0

ggagttctaaagaagaggtaatcgggtatcttttcg	CRISPR spacer
ggagttctaaagaagaggtaatcgggtatcttttcg	Protospacer
************************************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_000918

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_001880

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection