CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_004757	Nitrosomonas europaea ATCC 19718, complete genome	3 crisprs	DEDDh,cas2,cas1,csx1,csx16,cas6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,csa3,cas3,DinG,RT,PD-DExK,WYL	1	1	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_004757_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_004757_1

139594-140263

TypeIII

Consensus_repeat	Method
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	CRT
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	PILER-CR
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	CRISPRCasFinder

9 spacers

cas2,cas1,csx1,csx16,cas6,csm5gr7

The CRISPR arrays of NC_004757_1

>merge|NC_004757|1|139594-140263|CRT,PILER-CR,CRISPRCasFinder
CACTAATCCGGCGGTAATTCAGGGTATCGGTGTTTCGGTATCCTGCTGTTGAAAAAGATAGGTGGGCGTTGTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTCATCTATTGGCCGTATGGTTTCGAAGTAAAGATGGTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTCTCTACTGGTTCGAGACATATGAGGAAAAGTATTTGTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTCAAACCAGAATCAAGAAAGAAGACAAAAATTACTACGTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTCAAACCAGAATCAAGAAAGAAGACAAAAATTACTACGTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTCCCTTGGCTAACGCGATCAGTTATGGTGATCCTAAGTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTCGATTCCATGCCGAAATCTTTCCCAACGAGACCTATGTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTCTCGGCGTAGATTCGGAGAATACTGCTCGGGCAGTGGTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTCAGAATATTAATGTCGGCAATGTTCAGGCAAACGGAGTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC

>NC_004757|1|1|139594-140263|CRT
CACTAATCCGGCGGTAATTCAGGGTATCGGTGTTTC	GGTATCCTGCTGTTGAAAAAGATAGGTGGGCGTT
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	ATCTATTGGCCGTATGGTTTCGAAGTAAAGATG
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	TCTACTGGTTCGAGACATATGAGGAAAAGTATTT
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	AAACCAGAATCAAGAAAGAAGACAAAAATTACTAC
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	AAACCAGAATCAAGAAAGAAGACAAAAATTACTAC
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	CCTTGGCTAACGCGATCAGTTATGGTGATCCTAA
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	GATTCCATGCCGAAATCTTTCCCAACGAGACCTAT
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	TCGGCGTAGATTCGGAGAATACTGCTCGGGCAGTG
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	AGAATATTAATGTCGGCAATGTTCAGGCAAACGGA
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC

>NC_004757|1|1|139664-140263|PILER-CR
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	ATCTATTGGCCGTATGGTTTCGAAGTAAAGATG
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	TCTACTGGTTCGAGACATATGAGGAAAAGTATTT
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	AAACCAGAATCAAGAAAGAAGACAAAAATTACTAC
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	AAACCAGAATCAAGAAAGAAGACAAAAATTACTAC
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	CCTTGGCTAACGCGATCAGTTATGGTGATCCTAA
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	GATTCCATGCCGAAATCTTTCCCAACGAGACCTAT
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	TCGGCGTAGATTCGGAGAATACTGCTCGGGCAGTG
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	AGAATATTAATGTCGGCAATGTTCAGGCAAACGGA
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC

>NC_004757|1|1|139664-140263|CRISPRCasFinder
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	ATCTATTGGCCGTATGGTTTCGAAGTAAAGATG
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	TCTACTGGTTCGAGACATATGAGGAAAAGTATTT
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	AAACCAGAATCAAGAAAGAAGACAAAAATTACTAC
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	AAACCAGAATCAAGAAAGAAGACAAAAATTACTAC
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	CCTTGGCTAACGCGATCAGTTATGGTGATCCTAA
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	GATTCCATGCCGAAATCTTTCCCAACGAGACCTAT
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	TCGGCGTAGATTCGGAGAATACTGCTCGGGCAGTG
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC	AGAATATTAATGTCGGCAATGTTCAGGCAAACGGA
GTCTCAATCCCTTTGAAATCAGGGCATCGGTGTTTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_004757.1\|WP_011110753.1\|129565_130534_-\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|180588
NC_004757.1\|WP_011110760.1\|137821_138952_+\|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl\|CDD\|237265
NC_004757.1\|WP_158297450.1\|143420_143579_-\|hypothetical-protein	unknown	unknown	unknown
NC_004757.1\|WP_011110752.1\|128124_129399_-\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NC_004757.1\|WP_011110755.1\|131084_133154_-\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|224250
NC_004757.1\|WP_050731292.1\|135837_136992_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376777
NC_004757.1\|WP_011110757.1\|134975_135812_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|234599
NC_004757.1\|WP_011110770.1\|146125_146389_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|198034
NC_004757.1\|WP_011110765.1\|142113_143238_-\|TIGR02584-family-CRISPR-associated-protein	csx1	cd09686_csx1_CAS-III	gnl\|CDD\|274214
NC_004757.1\|WP_041356284.1\|130749_131061_-\|c-type-cytochrome	unknown	unknown	gnl\|CDD\|227001
NC_004757.1\|WP_011110771.1\|146416_148159_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl\|CDD\|187793
NC_004757.1\|WP_011110768.1\|144898_145195_-\|CRISPR-associated-protein-Csx16	csx16	pfam09652_csx16_CAS-I:CAS-III	gnl\|CDD\|200203
NC_004757.1\|WP_011110767.1\|143735_144902_-\|TIGR02221-family-CRISPR-associated-protein	csx1	cd09668_csx1_CAS-III	gnl\|CDD\|274040
NC_004757.1\|WP_011110756.1\|133175_134849_-\|dihydroxy-acid-dehydratase	unknown	unknown	gnl\|CDD\|234861
NC_004757.1\|WP_011110762.1\|140381_140699_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NC_004757.1\|WP_011110759.1\|136991_137771_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213228
NC_004757.1\|WP_011110764.1\|141737_142079_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NC_004757.1\|WP_011110761.1\|138990_139434_-\|hypothetical-protein	unknown	unknown	unknown
NC_004757.1\|WP_011110769.1\|145191_146148_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	cas6	mkCas0091_cas6_CAS-I:CAS-III	gnl\|CDD\|337605
NC_004757.1\|WP_011110763.1\|140732_141716_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|376633

Protein	Function_ID	Function_description	E-value
NC_004757.1\|WP_011110753.1\|129565_130534_-\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|180588	PRK06487, PRK06487, 2-hydroxyacid dehydrogenase.	0
NC_004757.1\|WP_011110760.1\|137821_138952_+\|succinyl-diaminopimelate-desuccinylase	gnl\|CDD\|237265	PRK13009, PRK13009, succinyl-diaminopimelate desuccinylase; Reviewed.	0
NC_004757.1\|WP_011110763.1\|140732_141716_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	2.99133e-94
NC_004757.1\|WP_011110755.1\|131084_133154_-\|thioredoxin-domain-containing-protein	gnl\|CDD\|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NC_004757.1\|WP_050731292.1\|135837_136992_+\|ABC-transporter-permease	gnl\|CDD\|376777	pfam02405, MlaE, Permease MlaE. MlaE is a permease which in E. coli is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. In NMB1965 it is involved in L-glutamate import into the cell. In Arabidopsis thaliana TGD1 it is involved in lipid transfer within the cell.	2.91546e-69
NC_004757.1\|WP_011110757.1\|134975_135812_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|234599	PRK00052, PRK00052, prolipoprotein diacylglyceryl transferase; Reviewed.	1.08848e-124
NC_004757.1\|WP_011110770.1\|146125_146389_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	gnl\|CDD\|198034	smart00966, SpoVT_AbrB, SpoVT / AbrB like domain. This domain is found in AbrB from Bacillus subtilis. The product of the abrB gene is an ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. AbrB is thought to interact directly with the transcription initiation regions of genes under its control. AbrB contains a helix-turn-helix structure, but this domain ends before the helix-turn-helix begins. The product of the B. subtilis gene spoVT is another member of this family and is also a transcriptional regulator. DNA-binding activity in this AbrB homologue requires hexamerisation. Another family member has been isolated from the Sulfolobus solfataricus and has been identified as a homologue of bacterial repressor-like proteins. The Escherichia coli family member SohA or Prl1F appears to be bifunctional and is able to regulate its own expression as well as relieve the export block imposed by high-level synthesis of beta-galactosidase hybrid proteins.	3.03715e-09
NC_004757.1\|WP_011110765.1\|142113_143238_-\|TIGR02584-family-CRISPR-associated-protein	gnl\|CDD\|274214	TIGR02584, hypothetical_protein_NE0113, CRISPR-associated protein, NE0113 family. Members of this minor CRISPR-associated (Cas) protein family are found in cas gene clusters in Vibrio vulnificus YJ016, Nitrosomonas europaea ATCC 19718, Mannheimia succiniciproducens MBEL55E, and Verrucomicrobium spinosum.	1.13232e-107
NC_004757.1\|WP_041356284.1\|130749_131061_-\|c-type-cytochrome	gnl\|CDD\|227001	COG4654, COG4654, Cytochrome c551/c552 [Energy production and conversion].	3.28273e-24
NC_004757.1\|WP_011110768.1\|144898_145195_-\|CRISPR-associated-protein-Csx16	gnl\|CDD\|200203	TIGR02620, hypothetical_protein, putative CRISPR-associated protein, VVA1548 family. This model represents a conserved domain of about 95 amino acids exclusively in species with CRISPR (Clustered Regularly Interspaced Short Palidromic Repeats). In all bacterial species with members so far (Vibrio vulnificus YJ016, Mannheimia succiniciproducens MBEL55E, and Nitrosomonas europaea ATCC 19718) and but not in the archaeon Methanothermobacter thermautotrophicus str. Delta H, the gene for this protein is in the midst of a cluster of Cas protein gene near CRISPR repeats.	2.99404e-54
NC_004757.1\|WP_011110767.1\|143735_144902_-\|TIGR02221-family-CRISPR-associated-protein	gnl\|CDD\|274040	TIGR02221, CRISPR-associated_protein_Csx1_2, CRISPR-associated protein, TM1812 family. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1812 of Thermotoga maritima, is found also in Vibrio vulnificus YJ016, Nitrosomonas europaea ATCC 19718, a large plasmid of Synechocystis sp. PCC 6803, and Fibrobacter succinogenes S85.	5.6329e-105
NC_004757.1\|WP_011110756.1\|133175_134849_-\|dihydroxy-acid-dehydratase	gnl\|CDD\|234861	PRK00911, PRK00911, dihydroxy-acid dehydratase; Provisional.	0
NC_004757.1\|WP_011110762.1\|140381_140699_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	4.31717e-14
NC_004757.1\|WP_011110759.1\|136991_137771_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213228	cd03261, ABC_Org_Solvent_Resistant, ATP-binding cassette transport system involved in resistant to organic solvents. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.89029e-124
NC_004757.1\|WP_011110764.1\|141737_142079_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.32982e-15
NC_004757.1\|WP_011110771.1\|146416_148159_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl\|CDD\|187793	cd09662, Csm5_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	6.02094e-12
NC_004757.1\|WP_011110769.1\|145191_146148_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	gnl\|CDD\|337605	pfam10040, CRISPR_Cas6, CRISPR-associated endoribonuclease Cas6. Cas6 is a member of the RAMP (repeat-associated mysterious protein) superfamily. It is among the most widely distributed Cas proteins and is found in both bacteria and archaea. Cas6 functions in the generation of CRISPR-derived guide RNAs for invader defense in prokaryotes.	2.43802e-08
NC_004757.1\|WP_011110752.1\|128124_129399_-\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.41763e-148

>NC_004757.1|WP_011110761.1|138990_139434_-|hypothetical-protein
MDILSLVAGFLAGALTIYLASYFMKPSENKTQKTVDAGTINLFDQLWQTHERLLNEMKQDVENPDFKFHREFYVLKKGWGWERWGFHRRGPCIAYFLEDHSDLLPLLDSLTSYGLISQTGETGKNTARFQLSEKLVELLRGKNTNKS
>NC_004757.1|WP_011110760.1|137821_138952_+|succinyl-diaminopimelate-desuccinylase
MSNSTLTLAQMLIARRSLTPDDDGCQKMIMHRLAGLGFKSDSMTFGEVENLWTRKGSDAPLVCFAGHTDVVPTGPVTQWDSDPFTPVVRDGFLYGRGAADMKTSLAAFVTAIEEFIELHPDHKGSIALLITSDEEGPAVDGTVKVVEALQTRGEMIDYCIVGEPTCTNQLGDTIKNGRRGSLSGNLTVRGIQGHIAYPHLARNPIHTAAPAIAELAQTVWDNGNEYFPATTWHISNIHGGTGATNVIPGEINLLFNFRFSTASTVDSLKARVHEILDRHGLDYELIWELSGKPYLTPRGTLADAVSAAIREVTGIEPELSTTGGTSDGRFIADICQQVVEFGPRNATIHKINESVEVADVERLARIYRLTLENLLL
>NC_004757.1|WP_011110759.1|136991_137771_+|ABC-transporter-ATP-binding-protein
MAIIDPVIEITGLTTRFGSHIIHENIDLTVYKGEILALVGGSGSGKTTLLRQMLGLVTPAQGSVRILGARRYDCGREEQRKLRTRSGVLFQQGALFSALTVFENVALPLREMRTLCEGTIRELVMLKLGMVGVEAQHARKMPAELSGGMVKRVALARALALDPELLFLDEPTAGLDPALSEGFVDLVRSLREELALTVIMVTHDLDTLVAISDRVAVLADRRIVALGPIPEIITIDHPFITAFFGGMRGRNALRALQQH
>NC_004757.1|WP_050731292.1|135837_136992_+|ABC-transporter-permease
MPSDLAAGNNSRYRLVTTAAGDTLLQLTGSFTLTSLDRSFPTVTKELAKLASQSDASSLHWDLTDVSQLDYAGAVMLWRIWGEQRPAHLLLRPEQERMFLRLEKSVSLPEQPRRILFLPISMLGKQLLRFLDHLTGMITLSGQIVLDLFFLMTHPGRIPAREISANLYRTGAQALGITAVVGFLIGIVLSYLTSEQLHMFGADIYIVNILGMSIIRELGPMLAAILVAGRSGSAMTAQLGVMRVTEELDALTVMGIPHSMRLVLPKIIGLGIALPLIVLWTSAIALLGGLVAAELQIGLSIHYALTALPDTVPIANLWLGLGKGMVCGMTIALIACHFGLRIKPNTESLGEGTTNSVVTSITAVILIDAIFAVAFSNIGIRIAS
>NC_004757.1|WP_011110757.1|134975_135812_+|prolipoprotein-diacylglyceryl-transferase
MLVHPQFDPVAISIGPLAVRWYGLMYLLGFSLFILLGRYRIRQQPNGVFTREMLDDALFYGVLGVILGGRLGHVLFYEPGYYLQHPLEILAIWQGGMSFHGGFLGVAIAMLCLARKYQLSWLAVTDFIAPLVPLGLGAGRIGNFINGELWGRPTDVPWGMIFPYADNLPRHPSQLYEFALEGLVLFALIWLYSAKPRPLGAVTGMFMIGYGAFRSFCEFFREPDDGFLGIMTLGISMGQWLSLPMIAAGIALLYWAYRYDGKPEKAARKLPRERKNRD
>NC_004757.1|WP_011110756.1|133175_134849_-|dihydroxy-acid-dehydratase
MPDNRRSQTITQGAQRTPNRAMLRAVGFGDGDFDKPIVGVANGFSTITPCNMGLDTLAKCAEHALKTAGAMPQMFGTITVSDGISMGTEGMKYSLVSREVIADSIETCVQAESMDGVIAIGGCDKNMPGAMIALARLNVPSIFVYGGTIKPGHYQGRDLTIVSAFEAVGQHTAHKIDDHELLEVERHACPGAGSCGGMYTANTMSSAIEAMGMSLPYSSTMAAEDEEKRISAIRSAEVLVDAVKKQILPRSLITRKSIENAVSVVMAVGGSTNAVLHLLAIAHAAEVEFSIDDFEAIRARVPVLCDLKPSGRYVATDLHKAGGIPQVMKMLLVHDLLHGDCLTISGQTIAEVLKDIPEQPRADQDVIQPWDNPVYEQGHLAILKGNLSSEGAVAKISGIKNPSITGPARVFDSEETCMAAILERKIQPGDVVVIRYEGPQGGPGMREMLSPTSALIGEGLGDSVGLITDGRFSGGTYGMVVGHVAPEAFAGGTIALVQEGDSITIDAHRRLLQLNVPEAELERRRAAWHPPAPRYTRGVLAKYAKLVSTASRGAVTD
>NC_004757.1|WP_011110755.1|131084_133154_-|thioredoxin-domain-containing-protein
MPNHLAGETSPYLLQHAENPVDWYPWGEEALEIARMLDKPILLSIGYSACHWCHVMAHESFEDAQVATAMNEHFVNIKVDREERPDIDQIYQSAHYTLNHRSGGWPLTMFLTPEQKPFFGGTYFPKEARYSMPGFLELLPKVAELYRTRKTDIEKQNAVLLKLLAQSLPAPDTRASALSRQPIDRAWEQLNRLFDETDGGFGDAPKFLHPAELQFCLRRYVTDNDTRALHVVTHTLEKMAQGGLYDQLGGGFCRYSTDHSWQIPHFEKMLYDNALMLPLYAETWLVTGNPLFKQVVEETAAWVIREMQSGIDGEGGYFSSLDADSEHEEGKFYVWDRQAVSAILTPEEYRVTAAYYGLDRSPNFENHHWHLAVTESIETVAARHQISQEAVQQLIDSARRKLLNEREQRIRPGRDEKILTSWNALMIKGMTRAGQIFEREEWISSAVRALDFIRSRLWQNDRLLATFKDDKAHLNAYLDDHAFLLDSLLTLLQADFRQTDLDFAITLADVLLTRFEDKTSGGFFFTSHDHETLIHRPKTGHDGAIPAGNGIAATTLQRLGHLLNEQRYLEAAERTLNVFSSGLSLHASSHCSLLITLEEFLEPTKTVILHGNRPELQIWLKALLPYSLDKIVIALPLELSELPDSLKMRSTPDGKISARVCEGRRCLPEIHSLNELLQMCKLHGRMALP
>NC_004757.1|WP_041356284.1|130749_131061_-|c-type-cytochrome
MKTAWLGTFAASALLVAGYAQADADLAKKNNCIACHQVETKVVGPALKDIAAKYADKDDAATYLAGKIKGGSSGVWGQIPMPPNVNVSDADAKALADWILTLK
>NC_004757.1|WP_011110753.1|129565_130534_-|2-hydroxyacid-dehydrogenase
MLTVFLDFGSVTRGDIDRTVLEQVVSPWVYHDNTSREQVAERIREAEIVVSNKTLLDRSALDAANKLKLICVAATGYNNVDLIAAAERNIPVCNVRNYATGSVAQHVFMFMLNFACRFVEYQQLIKRGGWQASSYFCPLDFGITELAGKTLGIVGYGELGNAVANIAKAFGMKLLIAEHKSASTIRPGRTAFDEVIRQTDFITLHCPLSEDTRHLISNRELNLMKPSAYLINTARSGLIDETDLLKSLYSKHIAGAAIDVLKEEPPVSGNPLLDYPHPNLIITPHSAWASVESRQRMLNLLADNIRNFLHNKPFNQIKDALA
>NC_004757.1|WP_011110752.1|128124_129399_-|MHS-family-MFS-transporter
MVSPFRQHRRILVASLVGTTIEFYDFYIYATAAALVFGPLFFPAESPSAQLMLSFLSFSLAFIARPFGAVLFGHFGDRIGRKSTLVASLLLMGISTLLIAFLPTYSTAGWIAPLLLCILRFGQGLGLGGEWGGAALLAVENAPPGWRGRFGMVPQLGAPIGFLAANGLFLLIGLQLSDADFAAWGWRIPFLASSILIVLGLWVRLKINETPEFTQALAQNPPVSIPFWELIRKHALITFAGTFTVVACFAIFYLSTAFALAHGTTTLGYDREQFLITQLAAIAFLAAGIIIAGIRADKASANQVLSWGCAATIGLGLTFGPALGAGSLWLVWGMLSLALFIMGFVYGPLGVWLPSLFPPRIRYTGVSVAFNAGGILGGALAPIIAQALTDAGGTSLVGLYLTMAGIFSLAGLKLVGKLMPDKTE
>NC_004757.1|WP_011110762.1|140381_140699_-|CRISPR-associated-endonuclease-Cas2
MPADHFLKRQAMSDFIICYDITDPRRLGRLYRYLIKRAVPLQYSVFLFRGDDRQLERCIQDAIELIDEKQDDLRVYPLPGRGLKARIGRPTLPEGIQWSGLPAKW
>NC_004757.1|WP_011110763.1|140732_141716_-|CRISPR-associated-endonuclease-Cas1
MTSLFVDRRGVELGLESGAIVFRENGERIGTVPIAPLTRVFLRGDVNLPAALLGKLGERGVGVVILSGRTSRPSLLLARPHNDAARRVAQVRLSLDEPASLIIARELIERKLTRQIEWFTELRENDIQARYELSRALRGLEEHRARLGNINNAASLRGIEGSAAARYFTGLQAVIPGSLHFHGRNRRPPRDPFNALLSLTYTLLHSEITIALHGAGFDPYIGFYHRLDFGRESLASDLLEPLRPLADRFAFALVHRRVLDKDHFTTTESGCLLGKAGRVRYYAAYEEHSEILRKGINQEIEQLAEQVGSALTPESGNTPDHDSGDWE
>NC_004757.1|WP_011110764.1|141737_142079_-|CRISPR-associated-endonuclease-Cas2
MLGTANLPSRNKYKAKATILHMNRNLYLVAYDICNPRRLRQVCRYLTGYKVSGQKSVFEIWVTPTELHTIRTELDKLMDTQADRLHILSLDPRMKPRCYGNASTFTVQHFCIV
>NC_004757.1|WP_011110765.1|142113_143238_-|TIGR02584-family-CRISPR-associated-protein
MPEPLQPHEYPHRILLCVTGLSPQIVTETLYALAVARATPFIPTEIHLLTTTDGARLARAALLHPDGGHFHALLNDQPQIGLPRFDEDCIHIISHHQEKLADIRTPAENAAAADTITALVAQLTEDADAALHVSIAGGRKTMGFYLGYAFSLFARPQDNLSHVLVSSPFEGHPDFFYPPRQPRRLVTRDGHHIDTAEAIVTLAEIPVVRLRHGLPATLIAGRAGFSETVVTLQQSFAPPCLLIDLEQRNVVCGTTAVAMKPQLLAWLAWWATLARQGRPETTWREADARLFLDIYRTVVGIDAIDYEKTAELLGNGMEKEFFQTKNAKLERVLKDTLGPAAAPYLLTTTGKRPHTRRGLTLPPERIRIVGTGSK
>NC_004757.1|WP_158297450.1|143420_143579_-|hypothetical-protein
MSILDSILGALEDVLKEAKDIPTENLAIIAVTTIGIAAIFKNSDSEKISSDW
>NC_004757.1|WP_011110767.1|143735_144902_-|TIGR02221-family-CRISPR-associated-protein
MTTLISFLGKGIADKTTGYRTATYRFDDDSKHTTPYFGLALAGYLRPERLILVGTAGSMWDVFFEQQDASDDDVLALIDAVRESRVDADMLSAQEKRLTKRLGLPVICRLIPYARDAAEQTEVLLTLAKLVHRSEEVFLDVTHGFRHLPMLALVAARYLAHVKDVKVRGLYYGALEMTSTNGETPVLQLDGMLQMLDWVESLATYNKDGDYGVFASLLQQDGLPEGKAKQLTRAAYFERSSNPVKARETLGSVFSAIKTHNGPMGVLFRDALTERINWFKEPDRAAWELALADAYLERRDYVRAVIYLYESFVTRAVLEHKLNPNDFSERDEAWKDARQDNKQVRKLEYLRNALAHGIKSDDKEIIRMVNDENCLDDQLKKFRRSLFN
>NC_004757.1|WP_011110768.1|144898_145195_-|CRISPR-associated-protein-Csx16
MTIWLVTRHPGAIEWVARQGIQWDKHAAHLDPCEITAGDTVIGSLPINLAAEICNRGARYFNLSLNLPAHLRGRELDAATLTACEARLEEYIVKKVNS
>NC_004757.1|WP_011110769.1|145191_146148_-|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6
MSTHHMAEFSSPTLSLGRYRLDWQVTRSIRLPDYAGSMLRGAFGHALRSIGCITREKDCTTCPLRRDCPYTILFEPVPPEHHPLQDFSRIPVPYIIEPPEWGTRVLHPGDTLSFHFTLIGCALQELPIAILAWRRALARGIGPDDGTAELTSIVLEQPDSSIPVYTPENGQIEPHETRLACPPPPAATIRLHITTPLRLQNNGVPLKAQTVTERALLMALVRRFALISEFHGEAAWQPDFRHLGELTSSVTGKRQLSWRDWQRYSSRQKQKMALGGLTGRWDLHGELAAFWPALWFGQWLHAGKNASFGLGRYRIIAA
>NC_004757.1|WP_011110770.1|146125_146389_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein
MNSAILSQDGRVVIPKKFRNKLEIKEGDEVIWKEEDEQIILTSRRQELERAERFFGQMMADYAGDSLADELIAERRAGAIYEHTSHG
>NC_004757.1|WP_011110771.1|146416_148159_-|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MKFLDTQELVVSTLSPVHIGCGEDYEPTEYVVDTSGVLHRFNAGILPDLSDAGISSDILTILSNDEAHTEQLRAVHKVLSKYRDKIIPLASVHVSMCTGVHAHYKSTQDKKNDFNRNGVERTSYQPFNQLPYLPGSSIKGAIRTAILNEHIAGNNPCSTVLMRQIQDFNTMIEEYDPGNGKLLLRLKLQHTKWDYDRARKNIEKAIADVSSALGTDLLGGKFETDPLRALKVSDAAPLDIEIEREIRFCLNRSRSGRRSQAQVKNLYTRLEYILEHQPAAFSLSLTLQNLHEIAGRRNHRNELISPSADKLLLWTGIVKACNSYYLNRLDDDLAMLGKLYPTSEWRKQTQSILDAGLRDQIKTGNCLLLRIGKHGGANSNTVSGRQIKIMLNEDKREANGKEEKIRLYTFDDESRTIWYCGDDLDKPSDLLPHGWIVLSNPDQIWHADLPGFERRCARQQAIAESARRQAEAAAAEQAKAAAQAAREAALAAMTENQRRIEAFVSMCARRAEQLRGGKENPNAAIHTAARELVKAALEGADWTIDEKCAVADAIEEWLPKLVKVELKDERKKLKLSALRT

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Crispr_ID: NC_004757_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_004757_2

921023-921636

Unclear

I-C,III-B

Consensus_repeat	Method
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	PILER-CR
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	CRISPRCasFinder
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	CRT

8 spacers

cas2

The CRISPR arrays of NC_004757_2

>merge|NC_004757|2|921023-921636|PILER-CR,CRISPRCasFinder,CRT
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAACTGGCAATCCTTGATCCATAACGAGATGACTAGCTTGTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAACATTGATGTTACAATCCGAGAAAACCGAGGCTCCTAGTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAACAGTGGCATCAGTAATAGATTTGTCAGGGTCACAGGCGTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAACTCTACCTCTCTTGATCTCCATCAGGAAATTGCCAGGTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAACTTTAAATCGCTAAGAATTACTGACCCTAATCTAAGTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAACACATCGTAATAGGCTGCATTACTGGCCCGTGTCAAGTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAACATGATGTATTCAGGTATCAGCGTCTGTGCCGGTAATGTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAACCCGGTAGTCGACCTATTAAAGCCATCATTTAATTAGTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC

>NC_004757|2|2|921023-921636|PILER-CR
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	TGGCAATCCTTGATCCATAACGAGATGACTAGCTT
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	ATTGATGTTACAATCCGAGAAAACCGAGGCTCCTA
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	AGTGGCATCAGTAATAGATTTGTCAGGGTCACAGGC
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	TCTACCTCTCTTGATCTCCATCAGGAAATTGCCAG
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	TTTAAATCGCTAAGAATTACTGACCCTAATCTAA
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	ACATCGTAATAGGCTGCATTACTGGCCCGTGTCAA
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	ATGATGTATTCAGGTATCAGCGTCTGTGCCGGTAAT
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	CCGGTAGTCGACCTATTAAAGCCATCATTTAATTA
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC

>NC_004757|2|2|921023-921636|CRISPRCasFinder
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	TGGCAATCCTTGATCCATAACGAGATGACTAGCTT
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	ATTGATGTTACAATCCGAGAAAACCGAGGCTCCTA
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	AGTGGCATCAGTAATAGATTTGTCAGGGTCACAGGC
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	TCTACCTCTCTTGATCTCCATCAGGAAATTGCCAG
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	TTTAAATCGCTAAGAATTACTGACCCTAATCTAA
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	ACATCGTAATAGGCTGCATTACTGGCCCGTGTCAA
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	ATGATGTATTCAGGTATCAGCGTCTGTGCCGGTAAT
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	CCGGTAGTCGACCTATTAAAGCCATCATTTAATTA
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC

>NC_004757|2|2|921023-921636|CRT
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	TGGCAATCCTTGATCCATAACGAGATGACTAGCTT
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	ATTGATGTTACAATCCGAGAAAACCGAGGCTCCTA
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	AGTGGCATCAGTAATAGATTTGTCAGGGTCACAGGC
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	TCTACCTCTCTTGATCTCCATCAGGAAATTGCCAG
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	TTTAAATCGCTAAGAATTACTGACCCTAATCTAA
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	ACATCGTAATAGGCTGCATTACTGGCCCGTGTCAA
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	ATGATGTATTCAGGTATCAGCGTCTGTGCCGGTAAT
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC	CCGGTAGTCGACCTATTAAAGCCATCATTTAATTA
GTAGCGCCCGGTCACCAGACCGGGCGAGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_004757.1\|WP_011111461.1\|924636_925311_-\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|334855
NC_004757.1\|WP_011111462.1\|925389_926502_+\|transglutaminase-domain-containing-protein	unknown	unknown	gnl\|CDD\|376628
NC_004757.1\|WP_011111452.1\|918811_919087_-\|mercury-resistance-system-periplasmic-binding-protein-MerP	unknown	unknown	gnl\|CDD\|131107
NC_004757.1\|WP_011111449.1\|916253_916619_-\|mercury-resistance-co-regulator-MerD	unknown	unknown	gnl\|CDD\|184299
NC_004757.1\|WP_041356560.1\|916020_916257_-\|broad-spectrum-mercury-transporter-MerE	unknown	unknown	gnl\|CDD\|184297
NC_004757.1\|WP_011111456.1\|920551_920842_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_004757.1\|WP_011111466.1\|931896_932595_+\|phosphoadenylyl-sulfate-reductase	unknown	unknown	gnl\|CDD\|234997
NC_004757.1\|WP_011111454.1\|919522_919948_+\|Hg(II)-responsive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|184302
NC_004757.1\|WP_011111458.1\|922350_923301_-\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213023
NC_004757.1\|WP_011111448.1\|915037_916024_-\|DUF3330-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NC_004757.1\|WP_011111460.1\|923928_924621_-\|VIT-family-protein	unknown	unknown	gnl\|CDD\|153123
NC_004757.1\|WP_011111453.1\|919100_919451_-\|mercuric-ion-transporter-MerT	unknown	unknown	gnl\|CDD\|184301
NC_004757.1\|WP_011111463.1\|926614_928336_-\|NADPH-dependent-assimilatory-sulfite-reductase-hemoprotein-subunit	unknown	unknown	gnl\|CDD\|237402
NC_004757.1\|WP_041356566.1\|928344_930177_-\|assimilatory-sulfite-reductase-(NADPH)-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|273882
NC_004757.1\|WP_011111451.1\|918360_918783_-\|organomercurial-transporter-MerC	unknown	unknown	gnl\|CDD\|237490
NC_004757.1\|WP_011111450.1\|916636_918322_-\|mercury(II)-reductase	unknown	unknown	gnl\|CDD\|184298
NC_004757.1\|WP_011111447.1\|914347_914908_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NC_004757.1\|WP_011111459.1\|923420_923873_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|224973
NC_004757.1\|WP_011111465.1\|930707_931664_-\|HTH-type-transcriptional-regulator-CysB	unknown	unknown	gnl\|CDD\|237173
NC_004757.1\|WP_011111457.1\|921638_922223_-\|NERD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377990

Protein	Function_ID	Function_description	E-value
NC_004757.1\|WP_011111461.1\|924636_925311_-\|dienelactone-hydrolase-family-protein	gnl\|CDD\|334855	pfam02230, Abhydrolase_2, Phospholipase/Carboxylesterase. This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.	4.75372e-49
NC_004757.1\|WP_011111462.1\|925389_926502_+\|transglutaminase-domain-containing-protein	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	1.26221e-26
NC_004757.1\|WP_011111452.1\|918811_919087_-\|mercury-resistance-system-periplasmic-binding-protein-MerP	gnl\|CDD\|131107	TIGR02052, periplasmic_mercuric_ion_binding_protein, mercuric transport protein periplasmic component. This model represents the periplasmic mercury (II) binding protein of the bacterial mercury detoxification system which passes mercuric ion to the MerT transporter for subsequent reduction to Hg(0) by the mercuric reductase MerA. MerP contains a distinctive GMTCXXC motif associated with metal binding. MerP is related to a larger family of metal binding proteins (pfam00403). [Cellular processes, Detoxification].	2.56187e-32
NC_004757.1\|WP_011111449.1\|916253_916619_-\|mercury-resistance-co-regulator-MerD	gnl\|CDD\|184299	PRK13749, PRK13749, HTH-type transcriptional regulator MerD.	3.20035e-66
NC_004757.1\|WP_041356560.1\|916020_916257_-\|broad-spectrum-mercury-transporter-MerE	gnl\|CDD\|184297	PRK13747, PRK13747, putative mercury resistance protein; Provisional.	5.37929e-46
NC_004757.1\|WP_011111456.1\|920551_920842_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.45097e-26
NC_004757.1\|WP_011111466.1\|931896_932595_+\|phosphoadenylyl-sulfate-reductase	gnl\|CDD\|234997	PRK02090, PRK02090, phosphoadenylyl-sulfate reductase.	4.34338e-115
NC_004757.1\|WP_011111454.1\|919522_919948_+\|Hg(II)-responsive-transcriptional-regulator	gnl\|CDD\|184302	PRK13752, PRK13752, mercuric resistance operon transcriptional regulator MerR.	7.32834e-101
NC_004757.1\|WP_011111458.1\|922350_923301_-\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213023	cd10918, CE4_NodB_like_5s_6s, Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, hemin storage system HmsF protein in gram-negative species, intercellular adhesion proteins IcaB, and many uncharacterized prokaryotic polysaccharide deacetylases. It also includes a putative polysaccharide deacetylase YxkH encoded by the Bacillus subtilis yxkH gene, which is one of six polysaccharide deacetylase gene homologs present in the Bacillus subtilis genome. Sequence comparison shows all family members contain a conserved domain similar to the catalytic NodB homology domain of rhizobial NodB-like proteins, which consists of a deformed (beta/alpha)8 barrel fold with 6 or 7 strands. However, in this family, most proteins have 5 strands and some have 6 strands. Moreover, long insertions are found in many family members, whose function remains unknown.	3.06911e-40
NC_004757.1\|WP_011111448.1\|915037_916024_-\|DUF3330-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	5.45965e-113
NC_004757.1\|WP_011111460.1\|923928_924621_-\|VIT-family-protein	gnl\|CDD\|153123	cd02432, Nodulin-21_like_1, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	6.24192e-98
NC_004757.1\|WP_011111453.1\|919100_919451_-\|mercuric-ion-transporter-MerT	gnl\|CDD\|184301	PRK13751, PRK13751, putative mercuric transport protein; Provisional.	4.12907e-76
NC_004757.1\|WP_011111463.1\|926614_928336_-\|NADPH-dependent-assimilatory-sulfite-reductase-hemoprotein-subunit	gnl\|CDD\|237402	PRK13504, PRK13504, NADPH-dependent assimilatory sulfite reductase hemoprotein subunit.	0
NC_004757.1\|WP_041356566.1\|928344_930177_-\|assimilatory-sulfite-reductase-(NADPH)-flavoprotein-subunit	gnl\|CDD\|273882	TIGR01931, Sulfite_reductase_flavoprotein_alpha-component, sulfite reductase [NADPH] flavoprotein, alpha-component. This model describes an NADPH-dependent sulfite reductase flavoprotein subunit. Most members of this family are found in Cys biosynthesis gene clusters. The closest homologs below the trusted cutoff are designated as subunits nitrate reductase.	0
NC_004757.1\|WP_011111451.1\|918360_918783_-\|organomercurial-transporter-MerC	gnl\|CDD\|237490	PRK13755, PRK13755, organomercurial transporter MerC.	2.28908e-85
NC_004757.1\|WP_011111450.1\|916636_918322_-\|mercury(II)-reductase	gnl\|CDD\|184298	PRK13748, PRK13748, putative mercuric reductase; Provisional.	0
NC_004757.1\|WP_011111447.1\|914347_914908_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	1.9614e-51
NC_004757.1\|WP_011111459.1\|923420_923873_-\|histidine-phosphatase-family-protein	gnl\|CDD\|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	1.08561e-31
NC_004757.1\|WP_011111465.1\|930707_931664_-\|HTH-type-transcriptional-regulator-CysB	gnl\|CDD\|237173	PRK12684, PRK12684, CysB family HTH-type transcriptional regulator.	0
NC_004757.1\|WP_011111457.1\|921638_922223_-\|NERD-domain-containing-protein	gnl\|CDD\|377990	pfam08378, NERD, Nuclease-related domain. The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.	1.46234e-10

>NC_004757.1|WP_011111456.1|920551_920842_+|CRISPR-associated-endonuclease-Cas2
MLIIVTYDVSTETRAGRKRLRRVAKLCESIGQRVQKSVFECRINLMQYEELERRLLSEIDEQEDNLRLYRLTEPAELHVKEYGNFKAIDFEGPLTI
>NC_004757.1|WP_011111454.1|919522_919948_+|Hg(II)-responsive-transcriptional-regulator
MQTILENLTIGAFARAAGVNVETIRFYQRKGLLPEPDKPYGSIRRYGEADVTRVRFVKSAQRLGFSLDEIAELLRLDDGTHCEEASSLAEHKLKDVREKMADLARMESVLSELVSACHLRQGNVSCPLIASLQGDASPAMP
>NC_004757.1|WP_011111453.1|919100_919451_-|mercuric-ion-transporter-MerT
MSEPQNGRGALFAGGLAAILASTCCLGPLVLVALGFSGAWIGNLTILEPYRPIFIGAALVALFFAWRRIYRPAEACKPGEVCAIPHVHTTYKLIFWIVAVLVLVALGFPYVMPFFY
>NC_004757.1|WP_011111452.1|918811_919087_-|mercury-resistance-system-periplasmic-binding-protein-MerP
MKKLFASLALVAVVAPVWAATQTVTLSVPGMTCAACPITVKKAISKVEGVSKTDVSFDKREAVVTFDDTKTNVQKLTKATEGAGYPSSVKR
>NC_004757.1|WP_011111451.1|918360_918783_-|organomercurial-transporter-MerC
MGLVTRIADKTGALGSVVSAMGCAACFPALASLGAAIGLGFLSQYEGLFISRLLPLFAAVAFIANALGWLSHRQWHRSVLGMIGPAIVFAATVWLLGNWWTANLMYVGLALMVGVSVWDFVSPANRRCGPDGCELPAKRG
>NC_004757.1|WP_011111450.1|916636_918322_-|mercury(II)-reductase
MTTLKITGMTCDSCATHVKQALEKVPGVQSAVVSYAKGAAQLDLDPGTAPDALTAAVAGLGYKATLADAPPTDNRTGLLDKVRDWMGAADKGSDGEHPLQVAVIGSGGAAMAAALKAVEQGAKVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPFDGGIPATAPAIDRSKLLAQQQARVDELRHAKYEGILDGNPAITVLHGEARFKDDQSLVVRLNAGGERVVVFDRCLVATGASPAVPPIPGLKESPYWTSTEALVSDIIPERLAVIGSSVVALELAQAFARLGSQVTILARSTLFFREDPAIGEAITAAFRAEGIKVLEHTQASQVAHVDGEFVLTTARGEIHADKLLVATGRTPNTRSLALEAAGVAVNAQGAIVIDKGMRTSAPHIYAAGDCTDQPQFVYVAAAAGTRAAINMTGGDATLDLTAMPAVVFTDPQVATVGYSEAEAHHDGIETDSRTLTLDNVPRALANFDTRGFIKLVIEEGSGRLIGVQAVAPEAGELIQTAALAIRNRMTAQELADQLFPYLTMVEGLKLAAQTFNKDVKQLSCCAG
>NC_004757.1|WP_011111449.1|916253_916619_-|mercury-resistance-co-regulator-MerD
MNAYTVSRLADDAGVSVHVVRDYIVRGLLRPVACTTGGYGLFDAAALQRLCFVRAAFDAGIGLGALARLCRALDAADGDGAAAQLAVLHQLVERRREALASLEMQLAAMPIESARQTESLP
>NC_004757.1|WP_041356560.1|916020_916257_-|broad-spectrum-mercury-transporter-MerE
MNSPERLPAETRKPVTGYLWGALAVLTCPCHLPILAAVLAGTTAGAFIGEHWGVAALALTGLFVLSVARLLRAFKGRS
>NC_004757.1|WP_011111448.1|915037_916024_-|DUF3330-domain-containing-protein
MTASRPVVWTATQLAQAVVLGQLELHYQPIVDLRSDQIAGAEALLRWRHPSLGLLPPGQFLPVAESSGLMPEIGAWVLREACQQMHEWLPVQWRPFRLAVNVSARQVGPGFDDQVQQALAAAGLLAEYLEIELTESAAFGDPAIFPLLDALRAIGVRFAADDFGTGYSCLQHLKCCPITTLKIDQSFVAGIVDDTRDQTIVRAVIQLAHGLGMEVVAEGVETPASLTQLRLADCDAVQGFLFAKPMPAAAFAAFVKRWRGVTMNVNEPTTSCCVCCKEIPLDAAFTPEGSEYVEHFCGLDCYERFQARAKAVAEPVTTPAAGGPTPSG
>NC_004757.1|WP_011111447.1|914347_914908_-|recombinase-family-protein
MQGQRIGYVRVSSFDQNPERQLEHVEVGRVFTDKASGKDTQRPELDSLLAFVREGDTVVVHSMDRLARNLDDLRRLVQKLTKRGVRIEFVKESLTFTGEDSPMANLMLSVMGAFAEFERALIRERQREGIALAKQRGVYRGRKKALSPEQVAELRQRAAAGEQKAKLAREFGVSRETLYQYLRLDQ
>NC_004757.1|WP_011111457.1|921638_922223_-|NERD-domain-containing-protein
MIIRNNSSFYRIDPLKSPIKANPLRNPGESLNHRLQNIFLDGIVPYFIAALCFVLIAAWEWIRWYTQTSPNPVLFTVMAIPCIATLLWKIYKGRKEVKRIKLGLAGELAVGQFLERLRAQGSHIFHDIPGKGFNLDHVVIHSSGIYVIETKTLSKPDRGESKLVYDGNHILKNSTALDRNPITQVRANSRWLRE
>NC_004757.1|WP_011111458.1|922350_923301_-|polysaccharide-deacetylase-family-protein
MKILPSLFSPAGKNSKLSIVIYHRVLPEPDLLTGEGGIAQFEKGLSYLTNNFNILPLSEAVNKLRSGTLPGRAACITFDDGYADNAEIALPILQKHGVTATFFIASGFLDGGRMWNDTVIESVRRAKGDKLDLNAIGLGNHAIATLEQRRETLNLLINKLKYLPHEARASQVDKLSTIIAADLPDNLMMISAQVRQLHDAGMEIGGHTLTHPILASIDDAAARTEIAEGKAKLEAIIDTPLRLFAYPNGKPGKDYLSAHVKMIKDAGFEAAVSTAWGAARQDSDMFQLPRFTPWDQSEWRYVLRMVRNMRQRIQTV
>NC_004757.1|WP_011111459.1|923420_923873_-|histidine-phosphatase-family-protein
MDLILWRHAEAEDGIPDATRKLTEKGLKQAQKMARWLEPKLPKDTRIIVSPATRTQQTVSALTHHFETSEQVGTSATPHRVLNTIAWPEAEGTVLVVGHQPTLGKIASLLLKGDESGFSVRKGSIWWFSSKQKDERESIILRAVMTPEIL
>NC_004757.1|WP_011111460.1|923928_924621_-|VIT-family-protein
MTHDNTHYSHRTGWLRAAVLGANDGIVSTASLIIGVASAHAAADDILLAGVAGVVAGAMSMAAGEYVSVSSQSDTEKADVALEQYHLDRDIDFELQELTDIYMKRGLQPELAAQVARELMAHDALDAHLRDELGLHERVNAKPVQAAFTSAGMFILGASMPLAATIAAPATTHIIPVVAISSLLSLTALGTFAAYLGKANMLTGAARVAFWGALAMAFTALTGTLFGIIA
>NC_004757.1|WP_011111461.1|924636_925311_-|dienelactone-hydrolase-family-protein
MPDNSFQLSAIDITTGSNPEYTILWMHGLGADGNDFVPVVQALDLPEIPIRFLFPHAPQQPVTINSGYIMRAWYDIQHTDFVEQEDETGIRRSQHAIVELIEREDRRGIPPDHLILAGFSQGAAMALHTGLRHPDRLAGIIALSGYLPLAHKIEREAHITNRITPIFMAHGNDDPIVPIELAHASLQQLREYYYPVTWHEYPMEHTVCDQELVDISRWLKTILK
>NC_004757.1|WP_011111462.1|925389_926502_+|transglutaminase-domain-containing-protein
MKRRSFFKLVGSSAAAAALFPAVARASLPPNQKWRSYQLTYQVTLPASGKVAKLWLPLPDASDTVYQFTQGNNWSGKATASAFYMLPGTQSQVFFALWQKGEERTVRVSSIVKTADRTVDLHSYRAPAKISIPQNIQRYLQSTKHIPLDDVVKKMARSVTSPANAHTPLQQARAIYDWVINNVAYDINGRGQGSGDLRSLLSRKENLSGKCGDIHALFVGLARASGIPARIQYGIRIGDSALNKNLGKSGDISTSQHCQAEFYLSGLGWVPVNPSDVARVMAAESLSHNHDSISQLREKLFGSWEMNWVAFNERENVDLGTTKVSAAISKLPFFGYPYAEIDGRLQDSLEPESFSYKITSAVLVGTGAKL
>NC_004757.1|WP_011111463.1|926614_928336_-|NADPH-dependent-assimilatory-sulfite-reductase-hemoprotein-subunit
MANTLPPTDRSCDISQPLERLSPDESLKAESDYLRGTIALGLLDRITSAVPGNDIKLMKFHGIYEQDDREIRDERRRQKLEPAFQFMIRVRLPGGICTTERWLKISELACAHGNETLRMTTRQTFQFHWVLKQNIVPLIRGLHEVLLDTVAACGDDSRGVMATVNPQFPALQAELAALAKTVSDHVIPKTRAYHEIWYGEERIASSEPEEPFYGQTYMPRKFKIGFVIPPNNDIDIYAQDLGYIAIIGENGKIAGFNVAIGGGMGRTDKAPHTYPRTASVIGFITPDRLISVTEAVMGVQRDYGNRADRSRARFKYTIDDKGLDWIKLAIEDRAGPLESARPYDFTSNADIYGWIESGDGFHHFTLFIENGRLNRDMLDKIAQIAHVHKGHFRLTPNQNLMIANVATADKPEIEALLRETGLIAFNERSVLRLNSMACVALPTCGLAMADSERYLPDLITKIEGILTRYNLQNEPITLRMTGCPNGCSRPFIAEIGLTGRAPGKYNLYLGGGFHGQRLNRLYRENIGEPAILETLNEVLGRYATERLPDEHFGDFTIRAGIIREVTEGRFSND
>NC_004757.1|WP_041356566.1|928344_930177_-|assimilatory-sulfite-reductase-(NADPH)-flavoprotein-subunit
MASQLSRGTLTAEQWQLVEALGSSLTPEHAYWISGYFAGLGSALLRSSGTASQSPDVCIPPVVTQAEPVAARSLTILHISETGNSTELAIRLAALAVEQGLSPTLVGIADYKVRKLKEEQDLLIITSTHGEGDPPQSGMEFFEFVEGRKAPSLSGLRYAILALGDMSYEHFCGAGKRLDERFEALGAKRLQPRVDCDVDYEDPAAVWSTGILALLAAEQASAISSVASPSKTTGGTQQANNSVYSKRNPFPATVIDNIVLSGRGSTRETHHIEISLADSGLTYEPGDALGIAAHNDPAMVEALLAALNMNPDAPLTVKGQTTTLFDALGKSFEITTATLRFLDHWGELTGTTDIFSAMDNTKRAAFLHDNHIIDIIRAYPLKGLDPQRFVDGLRPLQPRLYSIASSLSICPDEAHITIAPVRYKLHGEPRSGVASGHLADRAIADSVLPVYIQSNPHFRLPSNGEPIIMIGAGTGVAPYRAFMQEREANGGGRSWMFFGERNFRTDFLYQTEWQDWLKNGVLTKMEVAFSRDGAEKVYVQHRIYEHAHDVYAWLEEGAYIYLCGDASHMAPDVHNILVTVIEEQASVQREEAEEYLRDLQRDGRYQRDVY
>NC_004757.1|WP_011111465.1|930707_931664_-|HTH-type-transcriptional-regulator-CysB
MKLQQLKYLHEIAKQKLNLSKAANALHTSQPGISRQIQLLEQELGVEIFTRHGKRIIGITQPGLAILQTAQRMLQDADNLKKIGNEFNDKESGTFIIATTHTQARYVLPPVIKRFIEHYPKIRLSLRQGSPIEIATWVSSGEADLAIATEAIELFDKLVMLPCYEWNRCIVVPPRHPLLQLKELTLESIAQYAIVTYDFAFTGRSKINQAFESKGLKPNVVLTALDADVIKTYVEIGLGVGILAKMAFDPVRDKKLRAIDAAHLFEPSTTRIGICRNSYIRHYVYDFIEMFAAHLDMETVNKLLKNPENQQLSIANDK
>NC_004757.1|WP_011111466.1|931896_932595_+|phosphoadenylyl-sulfate-reductase
MGEQALQQKVEQLHSLLGNIQRDYSPAVFASSFGAEDMVLTDLIARHYPEIGIFTLDTGRLPEETYDLMQKVKERYGVSIHAYFPDASAVEHYVAQHGPNGFYDSVALRKRCCYIRKVEPLKRALADKKAWITGMRRDQSTTREELELSAYDSDHGLHKFNPLCDWTEKDVWNYIRQHDVPYNALHDRFYPSIGCAPCTRAITPGEDIRSGRWWWENPESRECGLHTRKIEA

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Crispr_ID: NC_004757_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_004757_3

1127490-1127597

Orphan

Consensus_repeat	Method
CATGAGACGATTCAGCTGCTTTGCCCTTGATTGCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_004757_3

>merge|NC_004757|3|1127490-1127597|CRISPRCasFinder
CATGAGACGATTCAGCTGCTTTGCCCTTGATTGCGACGTTTTCAGGGGTTCGATACGAGGAACTGCATCAGCATGAGACGATTCAGCTGCTTTGCCCTTGATTGCGAC

>NC_004757|3|3|1127490-1127597|CRISPRCasFinder
CATGAGACGATTCAGCTGCTTTGCCCTTGATTGCGAC	GTTTTCAGGGGTTCGATACGAGGAACTGCATCAG
CATGAGACGATTCAGCTGCTTTGCCCTTGATTGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_004757.1\|WP_011111648.1\|1129515_1129797_-\|cell-division-protein-FtsB	unknown	unknown	gnl\|CDD\|179156
NC_004757.1\|WP_011111642.1\|1120427_1121486_-\|lytic-murein-transglycosylase-B	unknown	unknown	gnl\|CDD\|274066
NC_004757.1\|WP_011111657.1\|1139544_1140165_+\|outer-membrane-lipoprotein-chaperone-LolA	unknown	unknown	gnl\|CDD\|367558
NC_004757.1\|WP_011111656.1\|1137181_1139485_+\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|236669
NC_004757.1\|WP_011111650.1\|1131520_1133215_-\|CTP-synthase	unknown	unknown	gnl\|CDD\|235437
NC_004757.1\|WP_011111658.1\|1140157_1141477_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NC_004757.1\|WP_011111640.1\|1118991_1120062_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NC_004757.1\|WP_011111652.1\|1133784_1134138_+\|succinate-dehydrogenase,-hydrophobic-membrane-anchor-protein	unknown	unknown	gnl\|CDD\|239574
NC_004757.1\|WP_011111636.1\|1114708_1115584_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|225176
NC_004757.1\|WP_011111653.1\|1134139_1135903_+\|succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|180814
NC_004757.1\|WP_011111654.1\|1135984_1136959_+\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|293786
NC_004757.1\|WP_011111641.1\|1120084_1120405_+\|heavy-metal-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|179490
NC_004757.1\|WP_011111643.1\|1122054_1122381_+\|thioredoxin-TrxA	unknown	unknown	gnl\|CDD\|200072
NC_004757.1\|WP_011111649.1\|1129793_1131080_-\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NC_004757.1\|WP_011111644.1\|1122603_1123863_+\|transcription-termination-factor-Rho	unknown	unknown	gnl\|CDD\|236490
NC_004757.1\|WP_011111637.1\|1115621_1116068_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_004757.1\|WP_011111645.1\|1124142_1124367_+\|50S-ribosomal-protein-L31	unknown	unknown	gnl\|CDD\|376487
NC_004757.1\|WP_041357123.1\|1117382_1118984_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
NC_004757.1\|WP_011111638.1\|1116257_1117289_+\|Fe(3+)-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270260
NC_004757.1\|WP_011111651.1\|1133398_1133791_+\|succinate-dehydrogenase,-cytochrome-b556-subunit	unknown	unknown	gnl\|CDD\|274370

Protein	Function_ID	Function_description	E-value
NC_004757.1\|WP_011111648.1\|1129515_1129797_-\|cell-division-protein-FtsB	gnl\|CDD\|179156	PRK00888, ftsB, cell division protein FtsB; Reviewed.	5.17022e-32
NC_004757.1\|WP_011111642.1\|1120427_1121486_-\|lytic-murein-transglycosylase-B	gnl\|CDD\|274066	TIGR02282, Membrane-bound_lytic_murein_transglycosylase_B, lytic murein transglycosylase B. This family consists of lytic murein transglycosylases (murein hydrolases) in the family of MltB, which is a membrane-bound lipoprotein in Escherichia coli. The N-terminal lipoprotein modification motif is conserved in about half the members of this family. The term Slt35 describes a naturally occurring soluble fragment of MltB. Members of this family never contain the putative peptidoglycan binding domain described by pfam01471, which is associated with several classes of bacterial cell wall lytic enzymes. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	4.8958e-126
NC_004757.1\|WP_011111657.1\|1139544_1140165_+\|outer-membrane-lipoprotein-chaperone-LolA	gnl\|CDD\|367558	pfam03548, LolA, Outer membrane lipoprotein carrier protein LolA.	1.88356e-62
NC_004757.1\|WP_011111656.1\|1137181_1139485_+\|DNA-translocase-FtsK	gnl\|CDD\|236669	PRK10263, PRK10263, DNA translocase FtsK; Provisional.	0
NC_004757.1\|WP_011111650.1\|1131520_1133215_-\|CTP-synthase	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NC_004757.1\|WP_011111658.1\|1140157_1141477_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NC_004757.1\|WP_011111640.1\|1118991_1120062_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	8.58293e-137
NC_004757.1\|WP_011111652.1\|1133784_1134138_+\|succinate-dehydrogenase,-hydrophobic-membrane-anchor-protein	gnl\|CDD\|239574	cd03494, SQR_TypeC_SdhD, Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the high potential quinine, ubiquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are classified as Type C SQRs because they contain two transmembrane subunits and one heme group. SdhD and SdhC are the two transmembrane proteins of bacterial SQRs. They contain heme and quinone binding sites. The two-electron oxidation of succinate in the flavoprotein active site is coupled to the two-electron reduction of quinone in the membrane anchor subunits via electron transport through FAD and three iron-sulfur centers. The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes.	1.9787e-35
NC_004757.1\|WP_011111636.1\|1114708_1115584_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	3.26158e-11
NC_004757.1\|WP_011111653.1\|1134139_1135903_+\|succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|180814	PRK07057, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
NC_004757.1\|WP_011111654.1\|1135984_1136959_+\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	9.80002e-29
NC_004757.1\|WP_011111641.1\|1120084_1120405_+\|heavy-metal-binding-domain-containing-protein	gnl\|CDD\|179490	PRK02877, PRK02877, hypothetical protein; Provisional.	3.06333e-57
NC_004757.1\|WP_011111643.1\|1122054_1122381_+\|thioredoxin-TrxA	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	2.11398e-51
NC_004757.1\|WP_011111649.1\|1129793_1131080_-\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NC_004757.1\|WP_011111644.1\|1122603_1123863_+\|transcription-termination-factor-Rho	gnl\|CDD\|236490	PRK09376, rho, transcription termination factor Rho; Provisional.	0
NC_004757.1\|WP_011111637.1\|1115621_1116068_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.89841e-29
NC_004757.1\|WP_011111645.1\|1124142_1124367_+\|50S-ribosomal-protein-L31	gnl\|CDD\|376487	pfam01197, Ribosomal_L31, Ribosomal protein L31.	3.06597e-42
NC_004757.1\|WP_041357123.1\|1117382_1118984_+\|iron-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	1.57717e-98
NC_004757.1\|WP_011111638.1\|1116257_1117289_+\|Fe(3+)-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270260	cd13542, PBP2_FutA1_ilke, Substrate binding domain of ferric iron-binding protein, a member of the type 2 periplasmic binding fold superfamily. FutA1 is the periplasmic component of an ABC-type iron transporter and serves as the primary receptor in Synerchosystis species. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria and is critical for survival of these pathogens within the host. After binding iron with high affinity, FutA1 interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The iron- and thiamine-binding proteins belong to the PBPI2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.81781e-142
NC_004757.1\|WP_011111651.1\|1133398_1133791_+\|succinate-dehydrogenase,-cytochrome-b556-subunit	gnl\|CDD\|274370	TIGR02970, Succinate_dehydrogenase_cytochrome_b556_subunit, succinate dehydrogenase, cytochrome b556 subunit. In E. coli and many other bacteria, two small, hydrophobic, mutually homologous subunits of succinate dehydrogenase, a TCA cycle enzyme, are SdhC and SdhD. This family is the SdhC, the cytochrome b subunit, called b556 in bacteria and b560 in mitochondria. SdhD (see TIGR02968) is called the hydrophobic membrane anchor subunit, although both SdhC and SdhD participate in anchoring the complex. In some bacteria, this cytochrome b subunit is replaced my a member of the cytochrome b558 family (see TIGR02046). [Energy metabolism, TCA cycle].	4.76043e-36

>NC_004757.1|WP_011111645.1|1124142_1124367_+|50S-ribosomal-protein-L31
MKEGIHPEYHEITVTCSCGNEFKTRSVLSKPLHIEVCSSCHPFYTGKQKIVDTAGRVEKFNQKYGRHLQKQAQT
>NC_004757.1|WP_011111644.1|1122603_1123863_+|transcription-termination-factor-Rho
MRLSDLKSIHVSELVKMAVANDIEGANRMRKQDLVFALLKNQARKSESIFGEGTLEILQDGFGFLRSPDTSYLAGPDDIYISPSQIRRFNLHTGDSVDGEIRPPKEGERYFALVKIDKVNNEPPENSKRKILFENLTPLFPTERLTLERDIKSEENITGRIIDLIAPIGKGQRGLLVASPKSGKTVMLQHIAHSIAANHPDVVLMVLLIDERPEEVTEMVRSVKGEVISSTFDESAARHVQVADMVIEKAKRLVEHKKDVVILLDSITRLARAYNTIVPASGKVLTGGVDANALQRPKRFFGAARNIEEGGSLTIIATALVDTGSRMDDVIYEEFKGTGNMEIHLDRRMAEKRIYPAINVNRSGTRREELLIPSEILQKIWILRKLLYPMDEMDAMSFLLDKIKATKNNADFFDSMRRV
>NC_004757.1|WP_011111643.1|1122054_1122381_+|thioredoxin-TrxA
MSQHIHYVTDASFESEVLQCPVPVLVDYWAEWCGPCRMIAPLLDEIASEYGDRLKIAKLNIDENQSTPQKYGIRGIPTLMIFKNGNIEATKVGALSKSQLTAFVDSHL
>NC_004757.1|WP_011111642.1|1120427_1121486_-|lytic-murein-transglycosylase-B
MFLRPAVTNPIKHNTFGHSRNRLTLFILTSLVTHHTSCMAEQPVSGLRLEIRSFVTDMVSRHGYDAHELEDAFIQTNFRPEILKLISTPASAISWDEYRKRFVNMQRIKGGVDFWNKYAADLERARKIYGVPEEIIVAIIGIETSYGSSTGNYRVMDALTTLAFDFPRRADYFREELENYLLLAREQKFGLLDIKGSYAGAIGVPQFMPGSYRRYAVDFNNDGKIDLSRSAVDAIGSIGNYLKEYGWEAGKPVAIRARAGSQNLQEFLDTDIKPLHSVWKLRQAGITPLDPVADDTLSALLELNSQGKRQLWLGFKNFYVITRYNRSTFYAMSVFELARAIHTARSSYSADR
>NC_004757.1|WP_011111641.1|1120084_1120405_+|heavy-metal-binding-domain-containing-protein
MLLTTTPVIEGKRITHYYGIVAGEAVLGANVLKDLFAGIRDFVGGRSGTYEKELQHAREIALEELQENAHRLGANAVIGIDIDYEVLGKENGMLMVSVSGTAVFVE
>NC_004757.1|WP_011111640.1|1118991_1120062_+|ABC-transporter-ATP-binding-protein
MSTLLELDRISHAYGAQVIVNELSFELEKGEIGCLLGPSGCGKTTVLRCIAGFEPIVSGEIRLNEISVSRAGFVLPPEQRRVGMVFQEYALFPHLTVTANVGFGLHRSTKAERAHRVAELLQITGLMEVANRYPHELSGGQQQRVALVRALAPYPDLILLDEPFSNLDVSLREYLGQEIRELLKKLNITAILVTHDQAEAFAVADKIGVMHAGKMMQWGSAHELYHHPANRFIADFIGQGTLIPGKVTHSDKVETELGTLAGNIYHPGHSSREIAGSQVDVLIRPDDVIHDNDSSLRAVVVHKAFRGAQFLYTLRLASGQSVLSLISSHHDHAIGEKIGIRPQTDHIVVFDRVNSQ
>NC_004757.1|WP_041357123.1|1117382_1118984_+|iron-ABC-transporter-permease
MRRAWRVFPFLVAGVVLVPVCVVFASFLSPDDEIWQHLISTTLPSLLTNTLWLSLGVIVGTSLLGVSLAWFTSVYRFPGYRFFSWALFLPLAIPAYVIAFVALGTFDYTGPVQTSLRHWFNSDLLWFPDIRSGPGVAIVMTLAFYPYVYLLSRDAFLTQGKRLLEVAQSLGFTRQQGFFRVVLPMARPWIVAGIMLALMETLADFGTVSIFNYDTFTTAIYKTWFGMFSLSTASQLASLLILIVLVIIMTEQRFRLRMRFSESRKSARVERIPLTGWQAMAVTGFAGTVLFFAFALPIIQLGIWAMDALTIGLDQRYLEFAWHSILLSVLAALITCLVAAMLAYAARLHSDGYTRFAIRLTTVGYALPGAVLAVGIFIPMAWLDNLLSDWIENISGVETGLLIQGTLTVMLVAYMTRFLAVSYFPLESALQRVTRSIDEAAAGFGVTGWSMLRMIYFPMLKSSLFTAATLVFVDVMKEMPITLMTRPFDWDTLAVRIFSLTSEGQWDQAALPALTLILTGLIPIILLIRHSET
>NC_004757.1|WP_011111638.1|1116257_1117289_+|Fe(3+)-ABC-transporter-substrate-binding-protein
MSRSFIFSGHVGRWCSSFLLIVFLFAVPISSQAEEIVVYSSRIEQLIKPLFDAFTKETGITVKFTTDKEGALLTRLLAEGKRTPADVLITTDAGNLWEAARNGLLKPVTSPVLQANIPENLQDPQGQWFGLTVRARTIVYNTRKVKPEELSTYADLADPKWKHRLCLRTSKKVYNQSLVAMMIAELGETETERIVKGWVDNLATDPVADDTLALEFVAAGRCDVTLVNTYYYGRLMRENPTLPLAIFWPNQATTGVHINVSGAGVIQYSKHGAAAVRLLEFLSSEQAQKLFVELNMEYPANPKVEYGELLNSWGSFKGDPRSIVQAGELQADAVRLMDRAGYR
>NC_004757.1|WP_011111637.1|1115621_1116068_+|universal-stress-protein
MSVYHHILLAVDFSSEDSQVVQKVRNLASQIGARLSLIHVLDNIPMPDTPYGTAIPLDTETTYDAMLDVEKQKLSQIGNTLGIDPAHRWLVWGEPREEIIRIAEQENVDLIVVGSHGRHGLALLLGSTANSVLHYAKCDVLAVRLRDD
>NC_004757.1|WP_011111636.1|1114708_1115584_+|alpha/beta-fold-hydrolase
MHNRVIRWILLQLVTALLIISAVTIILGEIVTGSAPTAVETLLPDFPVETVQIPVNDEYAVHGWLAHGMSGHGAVLLVHSMRSNRLEMLGRARFLNNQGYHVLMIDLQAHGETPGDRITFGARESADVAAAVGYLRSTFPHDRIAAIGATLGAAAIVLANPPLKLDAMILESLHPTFAEAVANRLKLHLGNTGEYLQFLLLPYFSFLLDLPVNQLNPVDRIGNIAIPVLFIAGTLDRHTTQSEVKRLYDAALPPKELWIVEGAGHYNMHTFAGKSYEMQIADFLSTYLQRQ
>NC_004757.1|WP_011111648.1|1129515_1129797_-|cell-division-protein-FtsB
MKIVAGLLVLLIGLAQYPLWFGKGSWLAILEMHEQIAALQEANQRLQNRNTVLEAEVNNLKKGFDAIEELARSELGMIRKNELFFRVVEYENK
>NC_004757.1|WP_011111649.1|1129793_1131080_-|phosphopyruvate-hydratase
MSAIVDVIAREIIDSRGNPTIEADVLLESGVLGRASVPSGASVGTREAVELRDGDAQRYYGKGVLKAVESVNGEISETIMGLDAMEQCFIDKTLIELDGSENKSRLGANAILAVSLAVAKAAAEESGLPLYRYLGGINAKWLPVPMMNLVNGGVHANNRLDMQEFMIIPLGLPNLREAVRCGAEVFSTLRTLLNKRNLPTTVGDEGGFAPSFARNEEALALIVQAIDEAGYQPGSEVAIGVDCASSEFFREGKYHLDVDGLGLTSAQFVDYLATWVEKYPIISIEDGMSEQDWEGWGLLTERLGKTVQLVGDDVFVTNTRILKEGISRNIANSILIKINQIGTLTETLNAIEMAKCAGYTAIVSHRSGETEDTTIADIAVATNALQIKTGSLSRSDRLAKYNQLLRIEEDLGEMAQYAGRSAFYQLKP
>NC_004757.1|WP_011111650.1|1131520_1133215_-|CTP-synthase
MTKFVFVTGGVVSSLGKGIAAASLAALLETRGIRVTILKLDPYINVDPGTMNPFQHGEVFVTDDGAETDLDLGHYERFISTKMTRQNNFTTGQIYESVIRKERRGDYLGGTVQVIPHITDEIKLFIRNGVSDAQVAIVEIGGTVGDIESLPFLEAIRQMSVQLPHHDTCFIHLTLLPYISSAGELKTKPTQHSVKELREIGIQPDVLLCRSDRPLPLEERRKIALFTNVREESVISAIDVDNIYKIPALLHEQMLDEIVCHRLDILARPANLTVWKKLVHALEHPEHEVSIALVGKYVDLTESYKSLSEALIHAGIHTRCKINIHYIDSENIEQHGTGCLTNMDAILVPGGFGKRGVEGKIMAISYARNHRIPYLGICLGMQLAVIEFSRNRLQLENAHSTEFDPDTPYPVLGLITEWRDRCGRVEKRSAQTDLGGTMRLGGQECLLKPHTLAHKIYGADKVIERHRHRYEVNAEFIPQLEQAGMHISGLSAEGDLCEMIELPQSEHPWFVACQFHPEFTSTPRNGHPLFKSYIQAAISFAGQSDRTKLHSRNVQESVTTDSSN
>NC_004757.1|WP_011111651.1|1133398_1133791_+|succinate-dehydrogenase,-cytochrome-b556-subunit
MEARYPAKRRPKYLNLLKIRQPLPAIVSILHRISGVLLFLPGIPLFLYGLQMLLQSPETFASLQSNLAHPLCKLFLLLATWFFIHHLLAGIRHLMLDLHYGMQLEQARLSSKLVLVFGAILTALTGIWLW
>NC_004757.1|WP_011111652.1|1133784_1134138_+|succinate-dehydrogenase,-hydrophobic-membrane-anchor-protein
MVKPVHRVVTGAHYGLKDWLVQRITAVLMAAYTGLLIILITVYQPESHEEFKALFSIQWMKIASLLFFAGLCWHAWVGVRNVLMDYVHPMPVRLTLQITCIVALLGYLIWFLDILWG
>NC_004757.1|WP_011111653.1|1134139_1135903_+|succinate-dehydrogenase-flavoprotein-subunit
MKVKQRKFDVVIVGAGGAGMRAALQLSEAGFKVAVLSKVFPTRSHTVAAQGGIAASLGNVTEDDWRWHMYDTVKGSDYLGDQDAIEFMCRHAAEVVYELEHFGMPFDRLENGKIYQRPFGGQSLNFGGEQASRSCAVADRTGHAMLHTLYQRNVSANTQFFVEWLGLDLIRDHEGEVLGITALEMETGEIMILQARATLLATGGAGRIFEASTNAFINTGDGLGMVARAGIPLEDMEFWQFHPTGVYGAGILISEAVRGEGGYLVNAEGERFMERYAPHARDLASRDVVSRALITEIRQGRGCGPKEDHLLLKLDHLSAETITSKLPGIREIALKFAHVDPLVDPIPVVPTAHYMMGGIPANYHGQVVAPYKTSPDEVVPGLYAVGECACVSVHGANRLGTNSLLDIVVFGRAAGNQIIKDLTRNNHHKPLPPDAAEQTLTRLDRLETQKDGENVAATSEALRKTMQTHCGVFRFPDVLKEGVEKIGEVAERVRHTEICDKSRVFNTARVEALELDNLIEVAIATMIAAEARHESRGAHTRDDFPERDDQKWLRHSLFFSKDQRLDYKPVRLKPLTVESFPPKARTY
>NC_004757.1|WP_011111654.1|1135984_1136959_+|ankyrin-repeat-domain-containing-protein
MKLTENMSFPVRLKQSCLAGVTALFFLLQIPFAHADADKDADFLKAALTGDTSGVENMLNEGIQTDLQSPEGFTALSVAAQTGHKEVVKLLLNRKATVDLANVQGGTPLLLASKNGHQEIVDLLLAKGANPNLQDKNGLAPLMLAAAKGNTGIVRSLLEHQAQPDLQNNAKATALHMAATNDYADIIDMLLAKGASVDLQDANGASALILASLSGHLSIVRKLLAHGAQPDLKATNDFTALILSAQNGQNPVIEVLLEKGVHIDFQNKDGMTALMSAVLNENIDTVKLLLEKGADTKLKNTSGKTALDIAKLPAIIELLKAAKS
>NC_004757.1|WP_011111656.1|1137181_1139485_+|DNA-translocase-FtsK
MSFADKPMAKKVASNPLPPRTSRLLREAVSLVLSGIALYLALILISFDRTDPGWSHSGTLRQVSNAGGSAGAWLADLMLYFFGISAWWWVVFFFATVWWGYRRIDIASVFDPRVLMLSFTGFITLLVASSGIEALRFHTLRISLPLAPGGLLGEILSKQLSSLLGFTGATLAMVIIFAIGFSLFSGLSWVRLSEKIGGGIEEICFAVRDICMGWLNRRNSTLPSSEREVRIEEIGKQPFPLVPLHIEMPETTPPRSTRSNREKQTPQFSNSPDGIIPPLHLLDEPQNNVEMLSSDTLEFTSRLIERKLQEFGVEVKVVAAYPGPVITRYEIEPAVGVKGNQIVNLVRDLARALTVASIRVVETIPGKTVMGLEIPNPNRQTVRLHEILASGVYANHPSPLTIALGKDISGRPVVSDLAKMPHALVAGTTGSGKSVAINAIILSLVYKASPDNVRLILIDPKMLELSVYDGIPHLLTPVVTDMRDAASALNWCVAEMERRYKLMSALGVRNLAGYNQKVREAVKNEEPLTNPLNPVPGSPELLEEMPLIVVVIDELADLMMIVGKKVEKLIARLAQKARAAGIHLLLATQRPSVDVITGLIKANIPTRIAFQVSSKIDSRTILDQMGAEALLGQGDMLYLPPGSGYPQRVHGAFVADHEVHKVVEYLKQHGEAHYIEEILQAGEEGALSDENGGESGKPAGGESDPLYDEAVSIVIKSRRASISLVQRQLRIGYNRAARLIEEMERAGLVSSMQSNGNREVLTPDRNE
>NC_004757.1|WP_011111657.1|1139544_1140165_+|outer-membrane-lipoprotein-chaperone-LolA
MTRLLFVLVLSVCLLPVPVKASAVKSLKTFVNKALTFQANFSQTLLDKNFQVIRKASGSMMFERPGKFRWTYDQPYQQLIVGDGKQVWFYDQDLAQVTVHRLDQALGSTPAALLAGGNTIERDFNLQEIDVQGETEWLEAIPKNQENSFELIRLGFSKTGILREMVLRDSFDQVTWLIFSEIEQNPTLTPDLFQFTPPEGVDVIRD
>NC_004757.1|WP_011111658.1|1140157_1141477_+|replication-associated-recombination-protein-A
MTDSPHTIRNPAAPLAERLRPRTLDDVVGQSHLLGPGKPLRLAFESGKPHSMILWGPPGSGKTTLARLMAHAFDAEFIAISAVLSGVKDIREAIERAQITLQRTGRATLLFVDEVHRFNKAQQDAFLPHVEQGLITFIGATTENPSFEVNGALLSRAQVYALKALTDQELHQLFERARSIAMLDLEFENTAIELLIGFADGDARRLLNLLEQVQNAAETEEIIKIDADYLSRVLARNVRRFDKGGDAFYDQISALHKSIRGSSPDAALYWLCRMLDGGADPRYIGRRLVRTATEDIGLADPRALTLALNACEVFERLGSPEGELALAQATLYLACAPKSNAAYVAYKQARAFIKEDISRPVPIHLRNAPTRLMREMGHGAAYRYAHDESESYAAGENYFPDNILAVQFYRPTTHGLEAKIGEKLAYLRSLDEKTGKKRN

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_004757_3	3.1\|1127527\|34\|NC_004757\|CRISPRCasFinder	1127527-1127560	34	NC_004757.1	2243679-2243712	0	1.0

1. spacer 3.1|1127527|34|NC_004757|CRISPRCasFinder matches to position: 2243679-2243712, mismatch: 0, identity: 1.0

gttttcaggggttcgatacgaggaactgcatcag	CRISPR spacer
gttttcaggggttcgatacgaggaactgcatcag	Protospacer
**********************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_004757_2	2.8\|921565\|35\|NC_004757\|PILER-CR,CRISPRCasFinder,CRT	921565-921599	35	NC_015903	Borreliella bissettii DN127 plasmid cp32-11, complete sequence	2565-2599	10	0.714
NC_004757_2	2.8\|921565\|35\|NC_004757\|PILER-CR,CRISPRCasFinder,CRT	921565-921599	35	NC_015904	Borreliella bissettii DN127 plasmid cp32-4, complete sequence	2565-2599	10	0.714
NC_004757_2	2.8\|921565\|35\|NC_004757\|PILER-CR,CRISPRCasFinder,CRT	921565-921599	35	NC_015905	Borreliella bissettii DN127 plasmid cp32-6, complete sequence	2565-2599	10	0.714
NC_004757_2	2.8\|921565\|35\|NC_004757\|PILER-CR,CRISPRCasFinder,CRT	921565-921599	35	NC_015908	Borreliella bissettii DN127 plasmid cp32-3, complete sequence	2565-2599	10	0.714

1. spacer 2.8|921565|35|NC_004757|PILER-CR,CRISPRCasFinder,CRT matches to NC_015903 (Borreliella bissettii DN127 plasmid cp32-11, complete sequence) position: , mismatch: 10, identity: 0.714

ccggtagtcgacctattaaagccatcatttaatta	CRISPR spacer
cttgctcgttaccttttaaagccataatttaatta	Protospacer
*. *.   . **** ********** *********

2. spacer 2.8|921565|35|NC_004757|PILER-CR,CRISPRCasFinder,CRT matches to NC_015904 (Borreliella bissettii DN127 plasmid cp32-4, complete sequence) position: , mismatch: 10, identity: 0.714

ccggtagtcgacctattaaagccatcatttaatta	CRISPR spacer
cttgctcgttaccttttaaagccataatttaatta	Protospacer
*. *.   . **** ********** *********

3. spacer 2.8|921565|35|NC_004757|PILER-CR,CRISPRCasFinder,CRT matches to NC_015905 (Borreliella bissettii DN127 plasmid cp32-6, complete sequence) position: , mismatch: 10, identity: 0.714

ccggtagtcgacctattaaagccatcatttaatta	CRISPR spacer
cttgctcgttaccttttaaagccataatttaatta	Protospacer
*. *.   . **** ********** *********

4. spacer 2.8|921565|35|NC_004757|PILER-CR,CRISPRCasFinder,CRT matches to NC_015908 (Borreliella bissettii DN127 plasmid cp32-3, complete sequence) position: , mismatch: 10, identity: 0.714

ccggtagtcgacctattaaagccatcatttaatta	CRISPR spacer
cttgctcgttaccttttaaagccataatttaatta	Protospacer
*. *.   . **** ********** *********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

12863 : 21533

Acinetobacter_phage(50.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011110662.1\|12863_14627_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	6.3e-64	29.4
WP_011110663.1\|14770_15367_-	cytochrome P460 family protein	NA	NA	NA	NA
WP_011110664.1\|15450_16371_-	indole-3-glycerol-phosphate synthase	A0A0P0IR83	Acinetobacter_phage	1.4e-51	42.8
WP_011110665.1\|16372_17398_-	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	2.3e-82	48.5
WP_011110666.1\|17394_17994_-	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	2.1e-72	65.3
WP_011110667.1\|18114_19614_+	HAMP domain-containing histidine kinase	Q6XLV6	Feldmannia_irregularis_virus	2.1e-07	23.6
WP_011110668.1\|19610_20153_+	hypothetical protein	NA	NA	NA	NA
WP_011110669.1\|20165_21533_+	sigma 54-interacting transcriptional regulator	W8CYM9	Bacillus_phage	1.1e-07	36.2

DBSCAN-SWA_2

268952 : 317307

Mannheimia_phage(37.5%)

tRNA,transposase,integrase

attL 263069:263116|attR 270332:270379

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
263069:263116	attL	NA	NA	NA	NA
WP_011110880.1\|268952_270203_-\|integrase	integrase family protein	A0A221SAN4	Ralstonia_phage	1.4e-12	24.2
WP_011110881.1\|270334_271894_-	recombinase family protein	NA	NA	NA	NA
270332:270379	attR	NA	NA	NA	NA
WP_143023732.1\|271907_272165_-	hypothetical protein	NA	NA	NA	NA
WP_011110883.1\|272566_273130_-	hypothetical protein	NA	NA	NA	NA
WP_011110833.1\|273265_274309_+\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	1.6e-147	73.9
WP_011110884.1\|274351_277450_-	SEL1-like repeat protein	NA	NA	NA	NA
WP_011110885.1\|277611_277908_-	hypothetical protein	NA	NA	NA	NA
WP_143023789.1\|278143_278509_+	hypothetical protein	NA	NA	NA	NA
WP_143023791.1\|278663_279698_+	hypothetical protein	NA	NA	NA	NA
WP_011110889.1\|281567_282023_+	hypothetical protein	NA	NA	NA	NA
WP_143023788.1\|282044_283664_+	type IV secretory system conjugative DNA transfer family protein	NA	NA	NA	NA
WP_050731223.1\|283771_284104_+	LysE family transporter	NA	NA	NA	NA
WP_050731225.1\|285163_285427_+	hypothetical protein	NA	NA	NA	NA
WP_011110891.1\|285942_287463_+	Fic family protein	NA	NA	NA	NA
WP_144039585.1\|287756_288984_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	7.6e-117	76.7
WP_011110833.1\|289299_290343_-\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	1.6e-147	73.9
WP_011110894.1\|290452_291271_-	hypothetical protein	NA	NA	NA	NA
WP_011110895.1\|291346_292789_-	hypothetical protein	NA	NA	NA	NA
WP_041356354.1\|292988_293177_-	hypothetical protein	NA	NA	NA	NA
WP_041356959.1\|293166_293775_-	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	7.2e-36	47.5
WP_011110897.1\|294018_294411_+	hypothetical protein	NA	NA	NA	NA
WP_011110898.1\|294412_295210_-	hypothetical protein	NA	NA	NA	NA
WP_143023785.1\|295202_295382_-	hypothetical protein	NA	NA	NA	NA
WP_011110899.1\|295736_296252_+	antirestriction protein ArdA	G9FHQ1	Rhodococcus_virus	2.9e-17	38.8
WP_011110900.1\|296384_296678_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_041356961.1\|296678_296915_-	type II toxin-antitoxin system ParD family antitoxin	NA	NA	NA	NA
WP_041356360.1\|297258_297603_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011110903.1\|297583_298096_+	SRPBCC family protein	NA	NA	NA	NA
WP_011110904.1\|298117_298369_+	YdeI/OmpD-associated family protein	NA	NA	NA	NA
WP_011110905.1\|298391_298871_+	VOC family protein	NA	NA	NA	NA
WP_011110906.1\|298949_299336_+	DUF1428 domain-containing protein	NA	NA	NA	NA
WP_011110833.1\|299642_300686_-\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	1.6e-147	73.9
WP_041356365.1\|300821_302126_-	hypothetical protein	NA	NA	NA	NA
WP_011110907.1\|302131_302503_-	plasmid mobilization relaxosome protein MobC	NA	NA	NA	NA
WP_011110910.1\|303852_304488_-	cytochrome c	NA	NA	NA	NA
WP_011110911.1\|304594_305197_+	hypothetical protein	NA	NA	NA	NA
WP_011110912.1\|305310_306129_+	type I methionyl aminopeptidase	NA	NA	NA	NA
WP_011110913.1\|306196_306922_+	ribonuclease PH	NA	NA	NA	NA
WP_041356963.1\|306947_307571_+	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase	A0A2H4UUV7	Bodo_saltans_virus	1.8e-05	27.9
WP_011110915.1\|307607_308807_+	oxygen-independent coproporphyrinogen III oxidase-like protein	NA	NA	NA	NA
WP_011110916.1\|308978_310820_+	copper resistance system multicopper oxidase	NA	NA	NA	NA
WP_011110917.1\|310816_311620_+	copper resistance protein B	NA	NA	NA	NA
WP_011110918.1\|311655_312597_-	hypothetical protein	NA	NA	NA	NA
WP_041356966.1\|312609_313182_-	LemA family protein	NA	NA	NA	NA
WP_011110920.1\|313306_313981_-\|tRNA	tRNA (guanosine(46)-N7)-methyltransferase TrmB	NA	NA	NA	NA
WP_011110921.1\|314009_314816_-	thiazole synthase	NA	NA	NA	NA
WP_011110922.1\|314890_315091_-	sulfur carrier protein ThiS	NA	NA	NA	NA
WP_011110923.1\|315292_315781_+	MEKHLA domain-containing protein	NA	NA	NA	NA
WP_011110924.1\|315849_316254_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_011110925.1\|316356_317307_+\|transposase	IS481-like element ISNe2 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

1331998 : 1404753

Burkholderia_virus(15.38%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_173251297.1\|1331998_1333018_-\|transposase	Rpn family recombination-promoting nuclease/putative transposase	S5VY82	Leptospira_phage	7.7e-06	25.4
WP_011111810.1\|1333143_1333407_+	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_011111811.1\|1333387_1333861_+	hypothetical protein	NA	NA	NA	NA
WP_158297463.1\|1333948_1334695_-	DUF2807 domain-containing protein	NA	NA	NA	NA
WP_011111813.1\|1335221_1335800_+	hypothetical protein	NA	NA	NA	NA
WP_011111814.1\|1336036_1337293_-	putative Na+/H+ antiporter	NA	NA	NA	NA
WP_143023722.1\|1337348_1338453_-	peptide chain release factor 2	G0YKC3	Acinetobacter_phage	1.9e-05	46.4
WP_041357152.1\|1338492_1339620_-	DUF1207 domain-containing protein	NA	NA	NA	NA
WP_011111817.1\|1339777_1340584_-	tellurite resistance TerB family protein	NA	NA	NA	NA
WP_041357153.1\|1340848_1342057_-	catalase family protein	NA	NA	NA	NA
WP_011111819.1\|1342059_1343586_-	peroxidase	NA	NA	NA	NA
WP_011111820.1\|1343600_1344905_-	hypothetical protein	NA	NA	NA	NA
WP_011111821.1\|1344938_1345394_-	hypothetical protein	NA	NA	NA	NA
WP_011111822.1\|1345777_1348447_+	hypothetical protein	NA	NA	NA	NA
WP_173251266.1\|1348549_1350496_+	GMC family oxidoreductase N-terminal domain-containing protein	A0A2K9L353	Tupanvirus	2.0e-50	27.7
WP_011111824.1\|1350583_1353445_-	oxygenase	NA	NA	NA	NA
WP_143023721.1\|1353500_1355168_-	lipoxygenase	NA	NA	NA	NA
WP_011111826.1\|1355233_1356835_-	cyclooxygenase	G8XT72	Simian_cytomegalovirus	1.0e-57	30.3
WP_011111827.1\|1357005_1358508_-	tyrosinase family protein	NA	NA	NA	NA
WP_011111828.1\|1358540_1358756_-	hypothetical protein	NA	NA	NA	NA
WP_041356718.1\|1358752_1359298_-	hypothetical protein	NA	NA	NA	NA
WP_041357155.1\|1359353_1360112_-	hypothetical protein	NA	NA	NA	NA
WP_011111831.1\|1360293_1361001_-	Kazal domain-containing protein	NA	NA	NA	NA
WP_011111833.1\|1361519_1362878_-	lysine 2,3-aminomutase	NA	NA	NA	NA
WP_078737663.1\|1363772_1363928_-\|transposase	transposase	NA	NA	NA	NA
WP_011111835.1\|1363929_1369071_-	Hpt domain-containing protein	W8CYM9	Bacillus_phage	1.8e-10	28.9
WP_011111836.1\|1369144_1371205_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	6.7e-17	29.9
WP_011111837.1\|1371535_1372180_-	type II secretion system protein	NA	NA	NA	NA
WP_011111838.1\|1372182_1372563_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_041356725.1\|1372567_1373011_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_143023724.1\|1372970_1373336_-	type II secretion system major pseudopilin GspG	NA	NA	NA	NA
WP_011111841.1\|1373420_1374641_-	type II secretion system F family protein	NA	NA	NA	NA
WP_011111842.1\|1374637_1376368_-	type II/IV secretion system protein	NA	NA	NA	NA
WP_041356728.1\|1376711_1376933_+	ribbon-helix-helix protein, CopG family	NA	NA	NA	NA
WP_041356729.1\|1377205_1377547_-	hypothetical protein	NA	NA	NA	NA
WP_086935148.1\|1377547_1378027_-	ParB N-terminal domain-containing protein	NA	NA	NA	NA
WP_011111844.1\|1378674_1379310_-	DUF416 family protein	NA	NA	NA	NA
WP_144039590.1\|1379497_1380725_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	9.9e-117	76.7
WP_011111846.1\|1382229_1383717_+	DUF853 domain-containing protein	A0A248XCZ8	Klebsiella_phage	6.4e-78	39.8
WP_011110809.1\|1383967_1385011_-\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	6.0e-147	73.6
WP_050731253.1\|1385101_1385485_-	glyoxalase/bleomycin resistance/dioxygenase family protein	NA	NA	NA	NA
WP_011111847.1\|1385549_1386059_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_011111848.1\|1386111_1386501_-	type II toxin-antitoxin system death-on-curing family toxin	A0A1X9I6C0	Streptococcus_phage	2.0e-10	35.2
WP_041356731.1\|1386497_1386725_-	AbrB family transcriptional regulator	NA	NA	NA	NA
WP_011111849.1\|1387551_1387758_-	type II toxin-antitoxin system HicB family antitoxin	NA	NA	NA	NA
WP_050731254.1\|1387892_1388564_-	DUF4136 domain-containing protein	NA	NA	NA	NA
WP_144039590.1\|1388562_1389790_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	9.9e-117	76.7
WP_143023676.1\|1389808_1390222_+	trypsin-like peptidase domain-containing protein	NA	NA	NA	NA
WP_011111851.1\|1390388_1391570_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011111852.1\|1391627_1392515_+	cytochrome c	NA	NA	NA	NA
WP_011111853.1\|1392594_1393296_-	hypothetical protein	NA	NA	NA	NA
WP_011111854.1\|1393781_1394186_+	DoxX family protein	NA	NA	NA	NA
WP_041357159.1\|1397398_1399756_+	endopeptidase La	A0A0R6PGP8	Moraxella_phage	1.9e-148	40.2
WP_041357160.1\|1399930_1400224_+	hypothetical protein	NA	NA	NA	NA
WP_011111858.1\|1400382_1400709_+	hypothetical protein	NA	NA	NA	NA
WP_011111859.1\|1400772_1402071_-	adenylosuccinate synthase	A0A2R8FF47	Brazilian_cedratvirus	3.6e-69	36.0
WP_011111860.1\|1402304_1403480_-	ATP phosphoribosyltransferase regulatory subunit	NA	NA	NA	NA
WP_041357161.1\|1403555_1403741_-	DUF2065 domain-containing protein	NA	NA	NA	NA
WP_011111862.1\|1403874_1404753_-\|protease	protease modulator HflC	NA	NA	NA	NA

DBSCAN-SWA_4

1653401 : 1715700

Paenibacillus_phage(37.5%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_144039591.1\|1653401_1654164_+\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	1.0e-23	43.2
WP_011110833.1\|1654580_1655624_+\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	1.6e-147	73.9
WP_041357187.1\|1655891_1656143_+	type II toxin-antitoxin system ParD family antitoxin	NA	NA	NA	NA
WP_011112092.1\|1656578_1656917_+	MliC family protein	NA	NA	NA	NA
WP_011112093.1\|1656956_1658159_-	acetyl-CoA C-acyltransferase	NA	NA	NA	NA
WP_143023750.1\|1658228_1660742_-	3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase family protein	NA	NA	NA	NA
WP_143023751.1\|1661066_1661561_-	redoxin domain-containing protein	NA	NA	NA	NA
WP_011112096.1\|1661560_1662799_-	exo-alpha-sialidase	NA	NA	NA	NA
WP_011112097.1\|1662876_1665003_-	TonB-dependent receptor	NA	NA	NA	NA
WP_011112098.1\|1665233_1667357_-	TonB-dependent receptor	NA	NA	NA	NA
WP_011112099.1\|1667658_1668963_-	M18 family aminopeptidase	NA	NA	NA	NA
WP_041356778.1\|1669481_1669760_-	nucleotidyltransferase family protein	NA	NA	NA	NA
WP_011112102.1\|1669972_1672525_-	TonB-dependent receptor	NA	NA	NA	NA
WP_011112103.1\|1672633_1673875_-	exo-alpha-sialidase	NA	NA	NA	NA
WP_011112104.1\|1674095_1675415_+	DUF2325 domain-containing protein	NA	NA	NA	NA
WP_011112105.1\|1675494_1677216_+	hypothetical protein	NA	NA	NA	NA
WP_011112106.1\|1677348_1679442_+	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	NA	NA	NA	NA
WP_011112107.1\|1679561_1679759_+	hemin uptake protein HemP	NA	NA	NA	NA
WP_011112108.1\|1679911_1680655_+	DUF2325 domain-containing protein	NA	NA	NA	NA
WP_011112109.1\|1680756_1681752_+	multicopper oxidase domain-containing protein	NA	NA	NA	NA
WP_011112110.1\|1681761_1682679_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_011112111.1\|1682809_1683676_+	pirin family protein	NA	NA	NA	NA
WP_041356779.1\|1683705_1684086_+	DoxX family protein	NA	NA	NA	NA
WP_041356780.1\|1684166_1684397_-	hypothetical protein	NA	NA	NA	NA
WP_011112114.1\|1684528_1686862_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_011112115.1\|1686858_1688697_+	long-chain fatty acid--CoA ligase	A0A1V0SBX8	Catovirus	1.9e-42	25.4
WP_143023749.1\|1688903_1689293_+	hypothetical protein	NA	NA	NA	NA
WP_011112117.1\|1689297_1689594_+	hypothetical protein	NA	NA	NA	NA
WP_144039592.1\|1690372_1691136_-\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	9.4e-25	44.1
WP_143023767.1\|1691221_1691524_+	hypothetical protein	NA	NA	NA	NA
WP_143023768.1\|1691602_1692085_+	hypothetical protein	NA	NA	NA	NA
WP_011112120.1\|1692107_1692632_+	hypothetical protein	NA	NA	NA	NA
WP_011112121.1\|1692645_1693005_+\|transposase	transposase	NA	NA	NA	NA
WP_074671328.1\|1693039_1693480_+\|transposase	transposase	NA	NA	NA	NA
WP_011112123.1\|1693556_1693973_+	hypothetical protein	NA	NA	NA	NA
WP_011112124.1\|1694060_1694564_+	DNA-deoxyinosine glycosylase	NA	NA	NA	NA
WP_011112125.1\|1694662_1694980_+	hypothetical protein	NA	NA	NA	NA
WP_011112126.1\|1695136_1695388_+	type II toxin-antitoxin system prevent-host-death family antitoxin	NA	NA	NA	NA
WP_011112127.1\|1695377_1695668_+	type II toxin-antitoxin system RelE/ParE family toxin	A0A2H4JBF4	uncultured_Caudovirales_phage	4.1e-21	54.7
WP_011112128.1\|1695724_1696417_+	ATPase	NA	NA	NA	NA
WP_011112129.1\|1696711_1698025_+	hypothetical protein	NA	NA	NA	NA
WP_143023771.1\|1698143_1699199_+	hypothetical protein	NA	NA	NA	NA
WP_011112131.1\|1699291_1700128_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_041357193.1\|1700124_1701111_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_011112133.1\|1701122_1701839_-	acylneuraminate cytidylyltransferase family protein	NA	NA	NA	NA
WP_011112134.1\|1702242_1704492_+	N-acetylneuraminate synthase family protein	NA	NA	NA	NA
WP_011112135.1\|1704665_1706081_+	hypothetical protein	NA	NA	NA	NA
WP_011112136.1\|1706214_1706961_-	SAM-dependent methyltransferase	NA	NA	NA	NA
WP_011112137.1\|1706971_1707355_-	Co2+/Mg2+ efflux protein ApaG	NA	NA	NA	NA
WP_011112138.1\|1707700_1709830_+	S8 family serine peptidase	A0A1B0T6A2	Bacillus_phage	6.7e-44	43.4
WP_143023769.1\|1709960_1710614_+	PEP-CTERM sorting domain-containing protein	NA	NA	NA	NA
WP_011112141.1\|1711066_1711363_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_041356785.1\|1711359_1711629_-	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_011112143.1\|1712012_1712351_-	type II toxin-antitoxin system PemK/MazF family toxin	NA	NA	NA	NA
WP_011112144.1\|1712335_1712578_-	ribbon-helix-helix protein, CopG family	NA	NA	NA	NA
WP_011112145.1\|1712784_1713213_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_011112146.1\|1713209_1713464_-	plasmid stabilization protein	NA	NA	NA	NA
WP_011112147.1\|1714057_1714306_+	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_011112148.1\|1714295_1714592_+	type II toxin-antitoxin system RelE/ParE family toxin	A0A2H4JBF4	uncultured_Caudovirales_phage	5.6e-18	52.1
WP_144039593.1\|1714951_1715700_-\|transposase	IS5-like element ISNeu3 family transposase	A0A0N9SHJ4	Paenibacillus_phage	9.3e-25	42.6

DBSCAN-SWA_5

1808308 : 1873609

Bacillus_virus(13.33%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011112230.1\|1808308_1809121_+\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA
WP_011112231.1\|1809122_1809521_+	50S ribosomal protein L19	NA	NA	NA	NA
WP_011110833.1\|1809712_1810756_+\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	1.6e-147	73.9
WP_086935135.1\|1810896_1811253_+	glycosyltransferase	NA	NA	NA	NA
WP_143023777.1\|1811191_1811965_+	glycosyltransferase	NA	NA	NA	NA
WP_011112232.1\|1811990_1812338_-	arsenate reductase family protein	NA	NA	NA	NA
WP_011112233.1\|1812347_1812866_-	hypothetical protein	NA	NA	NA	NA
WP_011112234.1\|1812937_1813195_-	DUF2024 family protein	NA	NA	NA	NA
WP_011112235.1\|1813253_1813916_-	O-methyltransferase	NA	NA	NA	NA
WP_050731308.1\|1813946_1815125_-	O-antigen ligase family protein	NA	NA	NA	NA
WP_041356799.1\|1816097_1817393_-	hypothetical protein	NA	NA	NA	NA
WP_011112240.1\|1817577_1818336_+	3-deoxy-manno-octulosonate cytidylyltransferase	NA	NA	NA	NA
WP_011112241.1\|1818355_1819117_+	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase	NA	NA	NA	NA
WP_011112242.1\|1819113_1820049_+	phosphoglycerate dehydrogenase	A0A2R8FDS8	Brazilian_cedratvirus	1.0e-33	34.5
WP_011112243.1\|1820041_1820986_+	NAD(P)-dependent oxidoreductase	A0A1D8KNX5	Synechococcus_phage	3.8e-07	25.4
WP_011112244.1\|1820982_1821639_+	HAD family hydrolase	NA	NA	NA	NA
WP_011112245.1\|1821620_1822307_+	6-phosphogluconolactonase	NA	NA	NA	NA
WP_011112246.1\|1822331_1822694_+	DMT family protein	NA	NA	NA	NA
WP_011112247.1\|1822741_1823395_-	DUF4126 domain-containing protein	NA	NA	NA	NA
WP_011112248.1\|1823455_1824463_-	glucokinase	NA	NA	NA	NA
WP_011112249.1\|1824727_1825654_+	serine acetyltransferase	NA	NA	NA	NA
WP_143023778.1\|1825746_1826922_+	NnrS family protein	NA	NA	NA	NA
WP_011112251.1\|1826918_1828187_-	O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase	NA	NA	NA	NA
WP_011112252.1\|1828412_1829384_-\|transposase	IS1595-like element ISNe7 family transposase	NA	NA	NA	NA
WP_011112253.1\|1829478_1830753_+	hypothetical protein	NA	NA	NA	NA
WP_011112254.1\|1830927_1834314_-	EAL domain-containing protein	G3MA91	Bacillus_virus	1.6e-23	37.9
WP_011112255.1\|1834590_1835928_+	peptide-methionine (S)-S-oxide reductase MsrA	NA	NA	NA	NA
WP_011112256.1\|1836013_1837441_-	PEP-CTERM sorting domain-containing protein	NA	NA	NA	NA
WP_011112257.1\|1838131_1838443_-	DUF190 domain-containing protein	A0A2H4J2R0	uncultured_Caudovirales_phage	2.1e-23	49.0
WP_011112258.1\|1838453_1838837_-	fluoride efflux transporter CrcB	A0A2H4J148	uncultured_Caudovirales_phage	4.3e-34	66.3
WP_011112259.1\|1839273_1841895_+	DNA mismatch repair protein MutS	A0A1V0SDQ0	Indivirus	5.3e-27	22.6
WP_011112260.1\|1841898_1842378_-	peptidylprolyl isomerase	NA	NA	NA	NA
WP_011112261.1\|1842392_1843046_-	ribonuclease HII	D2TEQ2	Emiliania_huxleyi_virus	1.5e-26	41.4
WP_011112262.1\|1843067_1843529_-	3-hydroxyacyl-ACP dehydratase FabZ	NA	NA	NA	NA
WP_011112263.1\|1843545_1844109_-	OmpH family outer membrane protein	NA	NA	NA	NA
WP_011112264.1\|1844135_1846412_-	outer membrane protein assembly factor BamA	NA	NA	NA	NA
WP_011112265.1\|1846414_1847782_-\|protease	RIP metalloprotease RseP	NA	NA	NA	NA
WP_011112266.1\|1847808_1849050_-	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
WP_011112267.1\|1849046_1849874_-	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_011112268.1\|1849912_1850704_-	di-trans,poly-cis-decaprenylcistransferase	R9W0U9	Flavobacterium_phage	2.3e-18	34.8
WP_011112269.1\|1850707_1851265_-	ribosome recycling factor	NA	NA	NA	NA
WP_011112270.1\|1851370_1852084_-	UMP kinase	NA	NA	NA	NA
WP_011112271.1\|1852238_1853123_-	elongation factor Ts	NA	NA	NA	NA
WP_011112272.1\|1853197_1853953_-	30S ribosomal protein S2	NA	NA	NA	NA
WP_041357219.1\|1854178_1854907_-	fumarate/nitrate reduction transcriptional regulator Fnr	NA	NA	NA	NA
WP_041357220.1\|1854989_1855304_-	c-type cytochrome	NA	NA	NA	NA
WP_143023730.1\|1855499_1857620_-	TonB-dependent receptor	NA	NA	NA	NA
WP_011112276.1\|1857894_1858320_-	transcriptional repressor	NA	NA	NA	NA
WP_041356800.1\|1858605_1858797_+	hypothetical protein	NA	NA	NA	NA
WP_011112277.1\|1858965_1860204_-	NnrS family protein	NA	NA	NA	NA
WP_173251299.1\|1860324_1861242_+	PHP domain-containing protein	NA	NA	NA	NA
WP_011112279.1\|1861299_1861932_+	threonylcarbamoyl-AMP synthase	NA	NA	NA	NA
WP_011112280.1\|1861924_1862590_+\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_011112281.1\|1862662_1863865_+\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_011112282.1\|1863904_1864705_+	segregation/condensation protein A	NA	NA	NA	NA
WP_011112283.1\|1864670_1865333_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	1.2e-23	36.3
WP_011112284.1\|1865345_1866593_+	NADP-dependent isocitrate dehydrogenase	Q77Z09	Phage_21	5.5e-06	46.3
WP_011112285.1\|1866713_1866917_-	cold-shock protein	A0A2H4N7Y6	Lake_Baikal_phage	2.0e-22	80.3
WP_011112286.1\|1867289_1867601_+\|protease	ATP-dependent Clp protease adapter ClpS	A0A1B1IT64	uncultured_Mediterranean_phage	5.9e-10	41.0
WP_011112287.1\|1867602_1869873_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	6.2e-173	43.2
WP_011112288.1\|1869891_1870575_+	orotate phosphoribosyltransferase	NA	NA	NA	NA
WP_011112289.1\|1870870_1871947_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_011112290.1\|1871951_1872788_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_041357224.1\|1872793_1873609_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.8e-34	38.9

DBSCAN-SWA_6

2376657 : 2428041

Mannheimia_phage(14.29%)

tRNA,protease,transposase,integrase

attL 2374916:2374931|attR 2385702:2385717

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2374916:2374931	attL	NA	NA	NA	NA
WP_011112687.1\|2376657_2377629_-\|integrase	integron integrase	A0A1P8DJJ6	Virus_Rctr41k	1.8e-68	46.1
WP_011112688.1\|2377769_2378141_+	hypothetical protein	NA	NA	NA	NA
WP_011112606.1\|2378247_2379561_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	2.8e-32	31.8
WP_158297474.1\|2379644_2379791_-	hypothetical protein	NA	NA	NA	NA
WP_011112689.1\|2380301_2381669_-	MFS transporter	NA	NA	NA	NA
WP_011112690.1\|2381665_2382439_-	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	2.8e-24	28.2
WP_143023783.1\|2382450_2382843_-	hypothetical protein	NA	NA	NA	NA
WP_011112692.1\|2382989_2383526_-	DUF615 domain-containing protein	NA	NA	NA	NA
WP_011112693.1\|2383767_2385135_+\|protease	metalloprotease PmbA	NA	NA	NA	NA
WP_011112694.1\|2385210_2386131_+	DMT family transporter	NA	NA	NA	NA
2385702:2385717	attR	NA	NA	NA	NA
WP_011112695.1\|2386219_2388625_-	RNA-binding transcriptional accessory protein	NA	NA	NA	NA
WP_011112696.1\|2388971_2389286_-	multidrug efflux SMR transporter	NA	NA	NA	NA
WP_011112697.1\|2389371_2390649_-	NAD(P)-binding domain-containing protein	NA	NA	NA	NA
WP_144039593.1\|2390792_2391540_+\|transposase	IS5-like element ISNeu3 family transposase	A0A0N9SHJ4	Paenibacillus_phage	9.3e-25	42.6
WP_158297477.1\|2391709_2391871_-	hypothetical protein	NA	NA	NA	NA
WP_078737683.1\|2392162_2392825_+	carbon-nitrogen hydrolase family protein	M1I0W4	Acanthocystis_turfacea_Chlorella_virus	4.8e-09	25.9
WP_011112698.1\|2393812_2394607_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_011112699.1\|2394657_2396550_-	SurA N-terminal domain-containing protein	NA	NA	NA	NA
WP_011112700.1\|2396894_2397167_-	HU family DNA-binding protein	A4JWM7	Burkholderia_virus	1.7e-21	64.0
WP_011112701.1\|2397379_2398369_-	NAD(P)-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_011112702.1\|2398365_2398854_-	SH3 domain-containing protein	NA	NA	NA	NA
WP_011112703.1\|2398857_2399343_-	protein-export chaperone SecB	NA	NA	NA	NA
WP_011112704.1\|2399417_2399675_-	glutaredoxin 3	V9QKN6	Rhizobium_phage	3.7e-10	43.4
WP_011112705.1\|2399706_2400129_-	rhodanese-like domain-containing protein	NA	NA	NA	NA
WP_011112706.1\|2400267_2401497_+	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	NA	NA	NA	NA
WP_011112707.1\|2401503_2402397_+	ATP-binding protein	NA	NA	NA	NA
WP_011112708.1\|2402398_2403334_+	Nudix family hydrolase	A0A221LFJ1	Barns_Ness_breadcrumb_sponge_sobemo-like_virus	7.0e-06	47.7
WP_011112709.1\|2403362_2404556_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011112710.1\|2404724_2406089_+	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	NA	NA	NA	NA
WP_050731317.1\|2406314_2407130_-	hypothetical protein	NA	NA	NA	NA
WP_011112712.1\|2407543_2408254_+\|tRNA	leucyl/phenylalanyl-tRNA--protein transferase	NA	NA	NA	NA
WP_041356853.1\|2408256_2408967_+	arginyltransferase	NA	NA	NA	NA
WP_011112714.1\|2408969_2409998_+	quinone-dependent dihydroorotate dehydrogenase	NA	NA	NA	NA
WP_011112715.1\|2409987_2410644_+	RnfABCDGE type electron transport complex subunit B	NA	NA	NA	NA
WP_011112716.1\|2410644_2411316_+	endonuclease III	G3CB03	Aeropyrum_pernix_spindle-shaped_virus	1.2e-12	23.4
WP_011112717.1\|2411312_2411708_+	nucleotidyltransferase domain-containing protein	NA	NA	NA	NA
WP_011112718.1\|2411697_2412135_+	DUF86 domain-containing protein	NA	NA	NA	NA
WP_011112719.1\|2412160_2413066_-	transglycosylase SLT domain-containing protein	NA	NA	NA	NA
WP_011112720.1\|2413307_2414870_-	TerC family protein	A0A0R6PEZ3	Moraxella_phage	2.0e-37	43.5
WP_011110833.1\|2415224_2416268_-\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	1.6e-147	73.9
WP_011112722.1\|2417794_2418211_+	hypothetical protein	NA	NA	NA	NA
WP_011112723.1\|2418224_2418638_+	nucleotidyltransferase domain-containing protein	NA	NA	NA	NA
WP_011110833.1\|2418812_2419856_-\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	1.6e-147	73.9
WP_078737670.1\|2419920_2420262_+	DUF86 domain-containing protein	NA	NA	NA	NA
WP_011112724.1\|2420647_2421631_+	fatty acid desaturase	NA	NA	NA	NA
WP_011112725.1\|2421662_2422778_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_011112726.1\|2422774_2424622_-	AMP-binding protein	A0A1V0SBX8	Catovirus	1.3e-35	21.8
WP_011112727.1\|2424691_2425762_-	hypothetical protein	NA	NA	NA	NA
WP_011112728.1\|2425794_2427483_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011112729.1\|2427597_2428041_-\|transposase	IS200/IS605 family transposase	A0A1L2BWN1	Bacteriophage	3.1e-12	31.9

DBSCAN-SWA_7

2624479 : 2672387

Mannheimia_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011112884.1\|2624479_2625472_+\|transposase	IS481-like element ISNe2 family transposase	NA	NA	NA	NA
WP_144039597.1\|2625691_2626400_+\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	6.7e-25	42.6
WP_011110809.1\|2626457_2627501_-\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	6.0e-147	73.6
WP_074671296.1\|2627720_2628320_+	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_050731285.1\|2628458_2630789_-	5-oxoprolinase/urea amidolyase family protein	NA	NA	NA	NA
WP_011112887.1\|2630852_2631512_-	urea carboxylase-associated family protein	NA	NA	NA	NA
WP_011112888.1\|2631508_2632237_-	urea carboxylase-associated family protein	NA	NA	NA	NA
WP_011112889.1\|2632314_2633832_-	amino acid permease	NA	NA	NA	NA
WP_158297478.1\|2633880_2634018_+	hypothetical protein	NA	NA	NA	NA
WP_011112890.1\|2634782_2638418_+	urea carboxylase	NA	NA	NA	NA
WP_011112891.1\|2638405_2639791_-	transglycosylase SLT domain-containing protein	A0A172JIA8	Bacillus_phage	1.2e-06	28.8
WP_011112892.1\|2639940_2641089_-	ribonucleotide-diphosphate reductase subunit beta	E5ER80	Bathycoccus_sp._RCC1105_virus	9.2e-32	28.0
WP_011112893.1\|2641129_2643997_-	ribonucleoside-diphosphate reductase subunit alpha	A0A2H4P767	Pseudomonas_phage	2.0e-176	44.9
WP_041356874.1\|2648207_2648636_-	hypothetical protein	NA	NA	NA	NA
WP_143779498.1\|2648681_2649338_-	class I SAM-dependent methyltransferase	A0A219VHB4	Ochrobactrum_phage	7.0e-61	54.3
WP_041356875.1\|2649444_2649816_-	DUF393 domain-containing protein	NA	NA	NA	NA
WP_011112897.1\|2649962_2650370_-	hypothetical protein	NA	NA	NA	NA
WP_011112899.1\|2651287_2651668_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_041356877.1\|2651671_2651878_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_041356878.1\|2652017_2652233_+	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_050731320.1\|2652448_2652631_-	hypothetical protein	NA	NA	NA	NA
WP_011112900.1\|2652659_2653850_-	PepSY domain-containing protein	NA	NA	NA	NA
WP_011112901.1\|2653860_2656332_-	TonB-dependent receptor	NA	NA	NA	NA
WP_011112902.1\|2656459_2657476_-	FecR family protein	NA	NA	NA	NA
WP_011112903.1\|2657489_2658047_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_011112904.1\|2658577_2659252_-	EcsC family protein	NA	NA	NA	NA
WP_086935153.1\|2659661_2661200_+	glucans biosynthesis protein MdoG	NA	NA	NA	NA
WP_011112906.1\|2661192_2663796_+	glucans biosynthesis glucosyltransferase MdoH	NA	NA	NA	NA
WP_078737675.1\|2664549_2664831_+	CsbD family protein	NA	NA	NA	NA
WP_011112908.1\|2665306_2665621_+	hypothetical protein	NA	NA	NA	NA
WP_011112909.1\|2665657_2665999_+	hypothetical protein	NA	NA	NA	NA
WP_011110833.1\|2666242_2667286_-\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	1.6e-147	73.9
WP_011112910.1\|2667488_2667941_-	DUF3465 domain-containing protein	NA	NA	NA	NA
WP_143023798.1\|2668022_2668412_-	DUF1311 domain-containing protein	NA	NA	NA	NA
WP_011110833.1\|2669024_2670068_+\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	1.6e-147	73.9
WP_158297479.1\|2670124_2670277_-	hypothetical protein	NA	NA	NA	NA
WP_041356882.1\|2670347_2670797_-	hypothetical protein	NA	NA	NA	NA
WP_041356883.1\|2671288_2671576_-	hypothetical protein	NA	NA	NA	NA
WP_144039593.1\|2671638_2672387_-\|transposase	IS5-like element ISNeu3 family transposase	A0A0N9SHJ4	Paenibacillus_phage	9.3e-25	42.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_004757

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection