CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_012121	Staphylococcus carnosus subsp. carnosus TM300, complete genome	1 crisprs	csa3,cas3,DEDDh,DinG,cas14j,WYL	0	0	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_012121_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012121_1

1549157-1549265

Orphan

Consensus_repeat	Method
ATATCAGTGTTTATAGGTGTGACCGAAATAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012121_1

>merge|NC_012121|1|1549157-1549265|CRISPRCasFinder
ATATCAGTGTTTATAGGTGTGACCGAAATAATTTAGTTCAGTCACAGTAAATATGGAGAATCTTGTTTTAAGCTTGTCATATCAGTGTTTATAGGTGTGACCGAAATAA

>NC_012121|1|1|1549157-1549265|CRISPRCasFinder
ATATCAGTGTTTATAGGTGTGACCGAAATAA	TTTAGTTCAGTCACAGTAAATATGGAGAATCTTGTTTTAAGCTTGTC
ATATCAGTGTTTATAGGTGTGACCGAAATAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012121.1\|WP_015900776.1\|1550830_1551718_-\|primase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|214926
NC_012121.1\|WP_015900764.1\|1541577_1542306_-\|hypothetical-protein	unknown	unknown	unknown
NC_012121.1\|WP_015900765.1\|1542386_1542935_-\|hypothetical-protein	unknown	unknown	unknown
NC_012121.1\|WP_015900784.1\|1554273_1555446_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271189
NC_012121.1\|WP_015900772.1\|1547021_1547480_-\|hypothetical-protein	unknown	unknown	unknown
NC_012121.1\|WP_015900773.1\|1547492_1548128_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NC_012121.1\|WP_015900786.1\|1557178_1557463_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NC_012121.1\|WP_015900767.1\|1543511_1543850_-\|hypothetical-protein	unknown	unknown	unknown
NC_012121.1\|WP_015900768.1\|1543846_1544161_-\|hypothetical-protein	unknown	unknown	unknown
NC_012121.1\|WP_015900769.1\|1544453_1544990_-\|hypothetical-protein	unknown	unknown	unknown
NC_012121.1\|WP_041612996.1\|1545017_1545491_-\|phage-terminase-small-subunit-P27-family	unknown	unknown	gnl\|CDD\|377461
NC_012121.1\|WP_015900780.1\|1552613_1553243_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226144
NC_012121.1\|WP_015900774.1\|1548321_1548786_-\|hypothetical-protein	unknown	unknown	unknown
NC_012121.1\|WP_015900781.1\|1553246_1553459_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379188
NC_012121.1\|WP_015900785.1\|1555514_1557137_-\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NC_012121.1\|WP_015900777.1\|1551820_1552135_-\|hypothetical-protein	unknown	unknown	unknown
NC_012121.1\|WP_015900787.1\|1557681_1558428_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_012121.1\|WP_015900779.1\|1552310_1552613_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|200128
NC_012121.1\|WP_015900775.1\|1549297_1550818_-\|nucleoside-triphosphatase	unknown	unknown	gnl\|CDD\|273716
NC_012121.1\|WP_015900766.1\|1542934_1543390_-\|SocA-family-protein	unknown	unknown	gnl\|CDD\|226128

Protein	Function_ID	Function_description	E-value
NC_012121.1\|WP_015900776.1\|1550830_1551718_-\|primase-C-terminal-domain-containing-protein	gnl\|CDD\|214926	smart00942, PriCT_1, Primase C terminal 1 (PriCT-1). This alpha helical domain is found at the C terminal of primases.	3.80759e-13
NC_012121.1\|WP_015900779.1\|1552310_1552613_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|200128	TIGR01764, Probable_excisionase, DNA binding domain, excisionase family. An excisionase, or Xis protein, is a small protein that binds and promotes excisive recombination; it is not enzymatically active. This model represents a number of putative excisionases and related proteins from temperate phage, plasmids, and transposons, as well as DNA binding domains of other proteins, such as a DNA modification methylase. This model identifies mostly small proteins and N-terminal regions of large proteins, but some proteins appear to have two copies. This domain appears similar, in both sequence and predicted secondary structure (PSIPRED) to the MerR family of transcriptional regulators (pfam00376). [Unknown function, General].	3.37446e-16
NC_012121.1\|WP_015900785.1\|1555514_1557137_-\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NC_012121.1\|WP_015900773.1\|1547492_1548128_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.000948254
NC_012121.1\|WP_041612996.1\|1545017_1545491_-\|phage-terminase-small-subunit-P27-family	gnl\|CDD\|377461	pfam05119, Terminase_4, Phage terminase, small subunit.	1.26478e-18
NC_012121.1\|WP_015900780.1\|1552613_1553243_-\|hypothetical-protein	gnl\|CDD\|226144	COG3617, COG3617, Prophage antirepressor [Transcription].	6.20769e-24
NC_012121.1\|WP_015900781.1\|1553246_1553459_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	1.61502e-12
NC_012121.1\|WP_015900786.1\|1557178_1557463_-\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	9.82078e-43
NC_012121.1\|WP_015900787.1\|1557681_1558428_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	2.02314e-10
NC_012121.1\|WP_015900784.1\|1554273_1555446_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	8.30616e-43
NC_012121.1\|WP_015900775.1\|1549297_1550818_-\|nucleoside-triphosphatase	gnl\|CDD\|273716	TIGR01613, putative_primase, phage/plasmid primase, P4 family, C-terminal domain. This model represents a clade within a larger family of proteins from viruses of bacteria and animals. Members of this family are found in phage and plasmids of bacteria and archaea only. The model describes a domain of about 300 residues, found generally toward the protein C-terminus. [DNA metabolism, DNA replication, recombination, and repair, Mobile and extrachromosomal element functions, Prophage functions].	9.06063e-112
NC_012121.1\|WP_015900766.1\|1542934_1543390_-\|SocA-family-protein	gnl\|CDD\|226128	COG3600, GepA, Uncharacterized phage-associated protein [Function unknown].	3.75873e-38

>NC_012121.1|WP_015900774.1|1548321_1548786_-|hypothetical-protein
MKNHLMPTDSLKLNKKKLNFNDIKNLENANRPICHIYKTQGKYQYLEIDFITCDWCLSSLGQATLQSRLNTESIFLWLRGYNLKLNYNSVGHMTIYLRGDHLAINYLLDEINKLTADAKYWQKYRDGKRMLEIDRNSHYVMPTHHIKGNTQKIS
>NC_012121.1|WP_015900773.1|1547492_1548128_-|hypothetical-protein
MAKLKEQAIEIFDNEIYAKSLQSKELNKDYNDLTSQLRELDHKIEYYRRDGDYAEVTKLKRKQSELENEIVKLDDKLNTDNFVVTEDEFERFYSAFDSELSEYKAKHQALKSEMNKQIDALKKTYHELVENKNNAGRIISRERYVANEKSNPGNINNLYKGQMLAHEINLGDGNKYDEQTTPRGYAWQLEKALDAVSHDDFQKYHFGKKKW
>NC_012121.1|WP_015900772.1|1547021_1547480_-|hypothetical-protein
MITAIRYKGNRAKVTENGEDLMILASSSSVPVELADADNKLNIVSAFEEGEIEPQAVKKIKFNKNSCVMMNGNLNFIIASSQRNNREFIVKKNHTLVHAWKSGDNAKDKAFDQIKGNKVDSVDVYVKNAEGKDNRVSHMGEILAVSINLNGA
>NC_012121.1|WP_041612996.1|1545017_1545491_-|phage-terminase-small-subunit-P27-family
MAQRKLLSQQKSRLTKEAQDNKRDTEKAMRQLTSLAPEPPEWLDDTATDEWHRIHPLLEELPVASLDLMLVSTYCQAYSDYINATKRMNNSDVIIETERGTKLNQNHTIKRDALSQLNSIAPKLGLTVESRLKILEPKQDTKSDKSVYEMFGIEDND
>NC_012121.1|WP_015900769.1|1544453_1544990_-|hypothetical-protein
MILKRSKNILWYYEEPKITEYELLTQYSPMMINSKLRVIQEQIDAMYHLNTSHMCCDEVEGVITVSYPLEKLVFWIIQQKEELDRFKNNSTKKLNLLKKIIRRYTPREQKEVMRYFQTNGSDRPHKTIDKLQEDLYKVHHNERIERNKQRQKESEVIYKNFLAETKASLNQEREELVI
>NC_012121.1|WP_015900768.1|1543846_1544161_-|hypothetical-protein
MTDVDYPILERYMRNYHSMVDIYKNKPSDMDELQYMNLESIVKGITEVYNDSEVKIQQIIKLTWWDDKKYTDEVIADVIGVSELTLRHAREVILKRVAKAVDYV
>NC_012121.1|WP_015900767.1|1543511_1543850_-|hypothetical-protein
MRYDKATVKEFILNYHKTINSSDAYNEDIDIDDFFNVNDQAETHDIDNNIEESIFYNELEAVVERVATEKEHNLFLLLCNGVSFEKAGSIFGVKEARAKQMLNKLLDKLELV
>NC_012121.1|WP_015900766.1|1542934_1543390_-|SocA-family-protein
MSNELKKIVEWFLSQQSMSPKKLQKMLYYAQAWCVTLSNETSEEIENKLFDDKFEAWVHGPVIPEVYQTYKKYGYNNIPKIDENIQLEEDIEDVLIQVMDVYGNFNGNQLENITHQEKPWIDARIGYSPLENCNEIITEEEMFDYYIKQAN
>NC_012121.1|WP_015900765.1|1542386_1542935_-|hypothetical-protein
MGKKKVKSSQKIQYNVSNDKNIVDNFKVVINSSEWLKSCVIKEINFSNKYHDYKEMAQTLTKVMTEVIFDIQQNGFDIFNKNSIYYQRNHHCHIIDGEKKEIVKKILDEIYTNKLDIDSDEEKKLWQYGVTSGLRIICLYDQANCLVHPLFIDPYHLIYPSEKYNKKDVMKNSFCPIESFII
>NC_012121.1|WP_015900764.1|1541577_1542306_-|hypothetical-protein
MLKKFFKTIGCILIIILSVFLVWYLNIFVLKTFSITGKNNDFYTGNATILAAIIAVVGVFFTIKHNNETKRKELLDNLDSKSEWRKQLYDVASKTILTTDDVYRVLASLRYIPKDSEDIAESKQKHFDVATREIFEDLYKIIKDMNIKKLENECMKGEEVETNLSFENGEIVKIYVKYLLKHHWEYNQDNPKKYHDSKEKDDFYAAKQEIKYIKNNGIKCYLEVMSNLSNKRGCLKLEKHKK
>NC_012121.1|WP_015900775.1|1549297_1550818_-|nucleoside-triphosphatase
MVDIYGFVEEETDKLIEEYQHQLQTVQKEKGNIKYFLKQLRKEELEIMRQQWEQAKEKGEASGAPPKTISPNRCAVLLNEHLTFILFDIEEGTRLAFYRQDEGIYTQNYTYIKRVISWLEPSYNQRKAEDVIFHLTNMVKIVPRTNEPHLIPVNNGVFNRETKKLESFTPDYVFTTKITTNYIEGAVQPTISGWSFDNWLDEVACGDREVFTLLWQVINDSLNGNYTRKKAIFLVGDGNNGKGTFQTLLSNLIGFDNVASLKVNEFDHEFKPSVLEGKTLVIGDDVPVGVNIEDSSNFNSVVTGDSILVNVKKKQPYRAVFRCTVIQSTNGMPRFKNKTGGTNRRLLIVPFNADFNGTKENPDIKEKYLNNKEVLEYVLYKAINLDFGKFIVPKVSADMLEEYKQDNDPVYDFKVTEFDTWKIDKVPKSVVYYRYKVFCENSGYHALSERKFYKTFNQYLSKNWEEERARFYSVADMQKKVGYFEPTLVPNGELKRSYINNKLKVV
>NC_012121.1|WP_015900776.1|1550830_1551718_-|primase-C-terminal-domain-containing-protein
MGFEQVKLQHDFKINVIEYKNLYSDSFVQSNKLLWSEWINRLQTPMNNGDKYKRGLVLYGDVKDMEKDGKLIQKYRNDENIINRNTLALDYDDITDFKGLYKSICKQLEGYAWAFHTTYNHTTDNPRIRLIVPINEPVSADDYRKYTQALAHQIGYKIDEGSYQPSRAMALPVRPDKDIPYIFKYNDAPAITIDDLNQLSTNLDNVQADKPFTINYSSQYKKRDSSYWRDIAFGVGEGERNQTLASLIGYLLRRYVDVNLVYGLAIAWAQQCTPAIDDKEVNNTFKSILKKDLNK
>NC_012121.1|WP_015900777.1|1551820_1552135_-|hypothetical-protein
MNYSQKIEETVECTDLGNKIQSCMDYLTTEIEAVEQTREWAIKNNEFRLQQEINNAWKSHYVALSILKSIREDNERMNDEIVMIVKNEQEKSASVQSANGTDNA
>NC_012121.1|WP_015900779.1|1552310_1552613_-|helix-turn-helix-domain-containing-protein
MFNINIDEDEAREMMQRAIDKRIEELAHEHYFMTYKELAEYLNLSKPTIEELLINNGMKYYMVGSTYRFKKSDVDDFMDHITSQMDITNNDLKSLKKVKS
>NC_012121.1|WP_015900780.1|1552613_1553243_-|hypothetical-protein
MIKQIFNDKEIRFIEKDDEYWAVAGDVAKVLGYSQTSNMLRMIDKEDVTTHNVKVTSNSKFARKTQPASVISEYGIYEAIWNSRRDEAQEFKKWVKQVIKELRQATGLKGYEAFRMLDKQKQKEAMAIIQRAYKSDKQINYIKANAIANKAVSTAFGYKKMIVKEEMTPDMLEVRQVILDDVVKLTETKNQFNLDIKVSKSIYDKYGVS
>NC_012121.1|WP_015900781.1|1553246_1553459_-|helix-turn-helix-transcriptional-regulator
MENKFRVILAIKKLSIADVFEGTGIAKTTLYGLYHEKTKNPDTSTILKVCNYLNITPNEFFGIDNNEKEA
>NC_012121.1|WP_015900784.1|1554273_1555446_+|tyrosine-type-recombinase/integrase
MASYDQIAKNNWRYRISLGKNPQTGKYEYISKTGFQRKSDAKHHAEMVERQIRNNEYIAPSAHTFSYIADEFINHYRKDAKVSSVRAREKAIKHAKVAFGDKAIQSITKHQYQQFVDDISTRFSKNYVDSIVASTNLVFKYALDMNLLKKLPNEGIKRPKQKVTVEELEHTELKQKFLEKEELFEFLNVAKNDHPPLNSFELFTLMAYSGCRAGEILALKWSDVDFDNYTINITKTYYNPNNNKKNYQILTPKTNASIGKLSIDPHVIKLLKDYKVNVQDKWKNELYVDNNFVFTDNNGYPLVIKKLSQWIQSIMSKTNIDKNITTHSFRYTHCALLIEAGVHIKEIQERLRHKDINTTMNIYAKITDSYKKDASQKFSQLMENVSKELF
>NC_012121.1|WP_015900785.1|1555514_1557137_-|chaperonin-GroEL
MAKEIKFSEDARQSMLRGVDQLANAVKVTIGPKGRNVVLDKEYGAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRKGIDKAVTEAVKSLHEQSQKVENKNEIAQVGAISAADEEIGQYISEAMDKVGNDGVISIEESNGFNTELEVVEGMQFDRGYQSPYMVTDSEKMEADLERPYILVTDKKISSFQDILPLLEQIVQSNRPILIIADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKSMLEDIAILTGAQFITDDLGYDLKDATVDMLGTANKVEVTKDNTTIVNGDGDKNSIDARVTQLKSQIEETNSDFDREKLQERLAKLTGGVAVIKVGAASETELKERKLRIEDALNSTRAAVGEGIVAGGGTALVNVYKQVSEIEAEGDVETGINIVLKALEAPVRQIAENAGLEGSIIVEKLKHAEPGIGYNAATDEWVNMLDAGIVDPTKVTRSALQNAASVAAMFLTTEAVVAKLPEENNDAGGPAMGGMSGMM
>NC_012121.1|WP_015900786.1|1557178_1557463_-|co-chaperone-GroES
MLKPLGNRVIIKRVESEQTTKSGIVLTEKAKEKSNEGKVIAVGPGRLLDNGERVTPEVKEGDTVVFEQYAGSEVQVGEDKYLVISEEEVLAIVQ
>NC_012121.1|WP_015900787.1|1557681_1558428_+|CPBP-family-intramembrane-metalloprotease
MSRLWFSILTLIVYACALFGVQGLYSAGVYNGLQGKSLMLATSYTQVGLMIAAAIIVLWMNAHVKNPTYLDNAPDKIKRRYIIPWAIVGLIVVLIYQVIASLINQFVFKVDQPSPNTTGIMRMIQDAPIFIVLVTIAGPLLEEFVFRKVIFGNIFEKLKGNKVIRFIIAATVSSALFATAHNDPSFIIIYFGMGFILSGFYVYSKRIAVPICIHILMNSYVVVIQLLFADKIKEMQESMQTILHFFLI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

380127 : 392600

uncultured_Caudovirales_phage(50.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015899630.1\|380127_381192_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	9.8e-20	25.2
WP_015899633.1\|382066_383569_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	3.8e-70	34.1
WP_015899634.1\|383797_385318_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	1.2e-71	36.9
WP_015899635.1\|385482_385986_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	7.8e-52	65.0
WP_015899636.1\|385988_386879_-	DMT family transporter	NA	NA	NA	NA
WP_015899637.1\|387759_388152_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	6.1e-44	67.7
WP_041612941.1\|388123_390229_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	87.3
WP_015899639.1\|390367_391342_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	2.2e-172	92.9
WP_174221513.1\|391643_392600_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4IY97	uncultured_Caudovirales_phage	3.4e-133	78.1

DBSCAN-SWA_2

470728 : 518911

Staphylococcus_phage(49.09%)

portal,protease,integrase,tail,holin,terminase,capsid,plate

attL 469451:469467|attR 477811:477827

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
469451:469467	attL	NA	NA	NA	NA
WP_174221512.1\|470728_471988_+	SufS family cysteine desulfurase	Q2XUY6	environmental_halophage	1.3e-103	44.4
WP_015899719.1\|471977_472448_+	SUF system NifU family Fe-S cluster assembly protein	NA	NA	NA	NA
WP_015899720.1\|472678_474076_+	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
WP_015899721.1\|474143_475193_-\|integrase	site-specific integrase	A0A2H4J4I8	uncultured_Caudovirales_phage	2.3e-183	88.5
WP_015899722.1\|475669_475852_-	hypothetical protein	NA	NA	NA	NA
WP_015899723.1\|476193_476658_-	ImmA/IrrE family metallo-endopeptidase	H9A0K3	Staphylococcus_phage	1.7e-45	56.0
WP_015899724.1\|476673_476997_-	helix-turn-helix transcriptional regulator	A0A1W6JP51	Staphylococcus_phage	3.8e-28	61.0
WP_050731401.1\|477171_477399_+	helix-turn-helix transcriptional regulator	Q4ZD52	Staphylococcus_phage	7.1e-13	54.8
WP_015899725.1\|477435_478203_+	phage antirepressor	M1RZB2	Staphylococcus_phage	4.5e-91	68.3
477811:477827	attR	NA	NA	NA	NA
WP_165380129.1\|478217_478364_+	hypothetical protein	A0A2H4JB78	uncultured_Caudovirales_phage	6.6e-12	80.0
WP_015899727.1\|478356_478581_-	hypothetical protein	A0A2H4JDC2	uncultured_Caudovirales_phage	1.4e-32	93.2
WP_167313206.1\|479124_479274_+	hypothetical protein	NA	NA	NA	NA
WP_015899728.1\|479251_479524_-	hypothetical protein	A0A1J0MFQ1	Staphylococcus_phage	1.3e-13	48.8
WP_015899729.1\|479587_479824_+	hypothetical protein	A0A1J0MG48	Staphylococcus_phage	1.3e-20	73.8
WP_041612947.1\|479820_480042_+	hypothetical protein	Q4ZCA4	Staphylococcus_virus	6.1e-17	64.4
WP_015899730.1\|480129_480375_+	hypothetical protein	Q4ZCA3	Staphylococcus_virus	9.1e-14	51.2
WP_015899731.1\|480367_480628_+	DUF2483 family protein	Q4ZCA2	Staphylococcus_virus	1.3e-37	96.4
WP_015899732.1\|480584_481256_+	ERF family protein	A0A1J0MF78	Staphylococcus_phage	5.1e-107	87.3
WP_015899733.1\|481255_481687_+	single-stranded DNA-binding protein	A0A1J0MFD7	Staphylococcus_phage	9.6e-51	71.7
WP_015899734.1\|481698_482250_+	HNH endonuclease	A0A2H4PQR4	Staphylococcus_phage	2.7e-82	78.1
WP_015899735.1\|482250_482925_+	hypothetical protein	I6TK06	Staphylococcus_virus	6.7e-107	81.2
WP_015899736.1\|482921_483683_+	conserved phage C-terminal domain-containing protein	A0A1W6JNI1	Staphylococcus_phage	6.4e-98	71.3
WP_015899737.1\|483683_484469_+	ATP-binding protein	A0A1W6JPS4	Staphylococcus_phage	9.8e-94	62.5
WP_015899738.1\|484634_485042_+	RusA family crossover junction endodeoxyribonuclease	Q4ZC94	Staphylococcus_virus	7.4e-53	71.1
WP_015899739.1\|485038_485215_+	hypothetical protein	NA	NA	NA	NA
WP_015899740.1\|485220_485751_+	hypothetical protein	NA	NA	NA	NA
WP_115314409.1\|485811_486228_+	DUF3310 domain-containing protein	A0A2H4JAP9	uncultured_Caudovirales_phage	4.6e-18	63.2
WP_015899742.1\|486220_486706_+	nucleoside 2-deoxyribosyltransferase	A0A1W6JQI2	Staphylococcus_phage	6.6e-56	69.1
WP_015899743.1\|486752_486950_+	hypothetical protein	Q4ZC85	Staphylococcus_virus	1.9e-14	61.7
WP_041612949.1\|486942_487146_+	hypothetical protein	NA	NA	NA	NA
WP_015899744.1\|487146_487656_+	dUTP pyrophosphatase	A0A1W6JQ84	Staphylococcus_phage	9.3e-61	73.6
WP_015899745.1\|487705_487912_+	hypothetical protein	NA	NA	NA	NA
WP_015899746.1\|487912_488155_+	DUF1381 domain-containing protein	U3PD04	Staphylococcus_phage	8.4e-12	72.9
WP_041612950.1\|488161_488434_+	hypothetical protein	A0A2H4JEE2	uncultured_Caudovirales_phage	6.5e-37	83.3
WP_015899747.1\|488426_488711_+	hypothetical protein	A0A1D6Z237	Staphylococcus_phage	4.7e-22	55.6
WP_174221511.1\|488777_489101_+	hypothetical protein	A0A2H4JHD4	uncultured_Caudovirales_phage	3.2e-06	63.2
WP_015899748.1\|489234_489414_+	hypothetical protein	NA	NA	NA	NA
WP_015899749.1\|489426_489840_+	hypothetical protein	A0A2H4J3L6	uncultured_Caudovirales_phage	4.3e-48	66.9
WP_041612952.1\|490134_490467_+	HNH endonuclease	D2XR61	Bacillus_phage	3.0e-28	59.6
WP_015899750.1\|490643_490991_+	hypothetical protein	A0A1W6JQ38	Staphylococcus_phage	4.0e-39	69.6
WP_015899751.1\|490987_492628_+\|terminase	terminase large subunit	A0A059T7Q8	Listeria_phage	1.0e-225	69.1
WP_115314408.1\|492693_493815_+\|portal	phage portal protein	A0A075M040	Staphylococcus_phage	4.1e-117	56.2
WP_015899753.1\|493804_494521_+\|protease	Clp protease ClpP	A0A1W6JPK0	Staphylococcus_phage	2.3e-57	47.6
WP_015899754.1\|494545_495664_+\|capsid	phage major capsid protein	A0A1W6JPL4	Staphylococcus_phage	1.7e-163	77.7
WP_015899755.1\|495736_496033_+	hypothetical protein	A8ATA0	Listeria_phage	3.3e-18	45.3
WP_015899756.1\|496007_496373_+	hypothetical protein	A8ATA1	Listeria_phage	4.4e-20	44.4
WP_015899757.1\|496369_496777_+	hypothetical protein	R4WAN5	Staphylococcus_phage	6.5e-41	62.4
WP_015899758.1\|496773_497169_+	hypothetical protein	Q4ZCL5	Staphylococcus_virus	7.0e-40	64.1
WP_015899759.1\|497210_497852_+\|tail	tail protein	Q9B0D5	Staphylococcus_virus	5.6e-95	77.9
WP_015899760.1\|497928_498390_+	Ig domain-containing protein	Q9B0D4	Staphylococcus_phage	1.7e-45	63.1
WP_015899761.1\|498437_498782_+	hypothetical protein	A0A2I6PEQ2	Staphylococcus_phage	8.8e-31	60.4
WP_015899762.1\|498832_498988_+	hypothetical protein	NA	NA	NA	NA
WP_015899763.1\|499001_501107_+\|tail	phage tail tape measure protein	A0A1X9IGU9	Staphylococcus_phage	6.9e-102	58.9
WP_081427455.1\|501054_505263_+	peptidoglycan DD-metalloendopeptidase family protein	H9A126	Staphylococcus_phage	9.2e-122	53.0
WP_015899765.1\|505259_506093_+\|tail	phage tail family protein	R4WAV3	Staphylococcus_phage	6.6e-72	54.0
WP_015899766.1\|506103_507669_+\|tail	phage tail protein	A0A2H4J2R7	uncultured_Caudovirales_phage	7.3e-149	50.8
WP_015899767.1\|507661_507880_+	hypothetical protein	NA	NA	NA	NA
WP_015899768.1\|507884_509840_+	right-handed parallel beta-helix repeat-containing protein	A0A2H4JHN3	uncultured_Caudovirales_phage	3.5e-15	35.2
WP_015899769.1\|509842_511267_+\|plate	BppU family phage baseplate upper protein	D7RWE2	Brochothrix_phage	6.5e-35	45.9
WP_015899770.1\|511271_511628_+	hypothetical protein	I6SAV6	Staphylococcus_virus	1.2e-09	31.0
WP_015899771.1\|511627_511801_+	XkdX family protein	NA	NA	NA	NA
WP_015899772.1\|511839_512262_+	hypothetical protein	A0A2H4JID2	uncultured_Caudovirales_phage	7.2e-59	77.9
WP_015899773.1\|512248_512647_+	hypothetical protein	A0A2H4JCM1	uncultured_Caudovirales_phage	2.3e-59	89.4
WP_015899774.1\|512693_514799_+\|plate	BppU family phage baseplate upper protein	Q4ZCC6	Staphylococcus_virus	1.2e-48	53.6
WP_015899775.1\|514857_515121_+\|holin	phage holin	A0A1W6JNV9	Staphylococcus_phage	3.6e-32	75.9
WP_015899776.1\|515120_516524_+	N-acetylmuramoyl-L-alanine amidase	A0A2H4JCA1	uncultured_Caudovirales_phage	1.8e-239	84.2
WP_015899777.1\|517217_517898_+	hypothetical protein	NA	NA	NA	NA
WP_015899778.1\|517890_518031_+	hypothetical protein	NA	NA	NA	NA
WP_015899779.1\|518110_518911_+	glycerophosphoryl diester phosphodiesterase	W0TWE2	Staphylococcus_phage	1.3e-37	41.1

DBSCAN-SWA_3

689073 : 700060

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015899939.1\|689073_689931_-	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	3.7e-38	38.4
WP_041612960.1\|690139_690622_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	3.1e-21	44.0
WP_015899941.1\|690608_691736_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_015899942.1\|691735_692440_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	E3SPA9	Prochlorococcus_phage	2.1e-50	46.4
WP_015899943.1\|692439_692706_+	phosphoribosylformylglycinamidine synthase subunit PurS	A0A1B1IU82	uncultured_Mediterranean_phage	2.9e-05	35.0
WP_015899944.1\|692705_693377_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_015899945.1\|693369_695559_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.6e-139	39.7
WP_015899946.1\|695537_696959_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.9e-48	31.2
WP_015899947.1\|696963_698001_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	7.7e-70	43.8
WP_015899948.1\|697997_698564_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.5e-30	39.1
WP_015899949.1\|698581_700060_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	3.3e-74	48.5

DBSCAN-SWA_4

1385527 : 1412528

Staphylococcus_phage(91.3%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015900611.1\|1385527_1386484_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.1e-66	85.2
WP_015900612.1\|1386488_1387046_+	class I SAM-dependent methyltransferase	A0A2H4PQV0	Staphylococcus_phage	1.5e-59	61.6
WP_015900613.1\|1387108_1388065_-	L-lactate dehydrogenase	NA	NA	NA	NA
WP_015900614.1\|1388257_1389088_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_015900615.1\|1389343_1390339_+	proline dehydrogenase family protein	A0A2H4PQT6	Staphylococcus_phage	1.3e-114	64.2
WP_015900616.1\|1390407_1390866_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.1e-57	80.3
WP_167313209.1\|1390898_1392077_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	5.0e-166	70.8
WP_015900618.1\|1392095_1392728_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.3e-72	63.3
WP_015900619.1\|1392734_1393784_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	4.2e-116	58.1
WP_015900620.1\|1394189_1395671_-	FAD/NAD(P)-binding protein	A0A2H4PQX2	Staphylococcus_phage	6.5e-14	64.5
WP_015900621.1\|1395808_1396654_-	glucosaminidase domain-containing protein	A0A1W6JQU5	Staphylococcus_phage	3.9e-40	42.9
WP_015900622.1\|1396973_1397195_-	hypothetical protein	NA	NA	NA	NA
WP_015900623.1\|1397397_1398333_+	sigma-70 family RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	4.1e-22	41.8
WP_015900624.1\|1398316_1398769_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	8.6e-18	41.5
WP_015900625.1\|1398896_1399613_-	transaldolase	R9TM64	Synechococcus_phage	6.6e-20	36.0
WP_015900626.1\|1399797_1400103_+	hypothetical protein	NA	NA	NA	NA
WP_015900627.1\|1400173_1400545_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.3e-39	65.3
WP_041612985.1\|1400537_1400894_+	CrcB family protein	NA	NA	NA	NA
WP_015900629.1\|1400940_1401864_-	ADP-ribosylglycohydrolase family protein	A0A1S6UB21	Serratia_phage	4.9e-36	31.6
WP_015900630.1\|1401874_1402717_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	7.0e-114	70.0
WP_015900633.1\|1404330_1405236_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	8.1e-100	75.2
WP_015900634.1\|1405327_1406524_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	4.7e-188	81.9
WP_015900635.1\|1406910_1408503_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	3.8e-254	78.8
WP_065865379.1\|1408552_1409332_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	1.2e-91	65.7
WP_015900637.1\|1409315_1409789_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	1.1e-34	47.1
WP_015900638.1\|1409877_1410132_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	4.2e-30	70.6
WP_015900639.1\|1410128_1411136_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	1.6e-93	51.0
WP_015900640.1\|1411139_1412528_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	5.1e-162	59.7

DBSCAN-SWA_5

1540294 : 1557463

uncultured_Caudovirales_phage(43.75%)

terminase,integrase

attL 1538365:1538378|attR 1555491:1555504

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1538365:1538378	attL	NA	NA	NA	NA
WP_015900761.1\|1540294_1540873_+	hypothetical protein	A0A1D6Z277	Staphylococcus_phage	1.4e-12	68.4
WP_041612995.1\|1540923_1541310_-	YbgA family protein	NA	NA	NA	NA
WP_015900763.1\|1541337_1541529_-	hypothetical protein	U3PCX8	Staphylococcus_phage	3.3e-27	85.7
WP_015900764.1\|1541577_1542306_-	hypothetical protein	NA	NA	NA	NA
WP_015900765.1\|1542386_1542935_-	hypothetical protein	NA	NA	NA	NA
WP_015900766.1\|1542934_1543390_-	SocA family protein	I6R0L8	Salmonella_phage	6.6e-18	37.9
WP_015900767.1\|1543511_1543850_-	hypothetical protein	NA	NA	NA	NA
WP_015900768.1\|1543846_1544161_-	hypothetical protein	A0A2H4JEA5	uncultured_Caudovirales_phage	1.1e-22	52.0
WP_015900769.1\|1544453_1544990_-	hypothetical protein	A0A2H4JB26	uncultured_Caudovirales_phage	4.6e-42	48.6
WP_041612996.1\|1545017_1545491_-\|terminase	phage terminase small subunit P27 family	A0A2H4JB21	uncultured_Caudovirales_phage	8.6e-53	68.8
WP_015900772.1\|1547021_1547480_-	hypothetical protein	A0A2H4JGU4	uncultured_Caudovirales_phage	2.1e-72	92.1
WP_015900773.1\|1547492_1548128_-	hypothetical protein	A0A2H4JFF8	uncultured_Caudovirales_phage	1.0e-48	47.6
WP_015900774.1\|1548321_1548786_-	hypothetical protein	NA	NA	NA	NA
WP_015900775.1\|1549297_1550818_-	nucleoside triphosphatase	A0A1P8BMT9	Lactococcus_phage	8.2e-105	45.1
WP_015900776.1\|1550830_1551718_-	primase C-terminal domain-containing protein	A0A1W6JQL5	Staphylococcus_phage	2.0e-79	51.2
WP_015900777.1\|1551820_1552135_-	hypothetical protein	NA	NA	NA	NA
WP_015900779.1\|1552310_1552613_-	helix-turn-helix domain-containing protein	A0A2H4JHK0	uncultured_Caudovirales_phage	2.7e-36	75.8
WP_015900780.1\|1552613_1553243_-	hypothetical protein	A0A1W6JPC3	Staphylococcus_phage	1.7e-59	60.7
WP_015900781.1\|1553246_1553459_-	helix-turn-helix transcriptional regulator	A0A1W6JQE8	Staphylococcus_phage	1.3e-24	82.8
WP_015900784.1\|1554273_1555446_+\|integrase	tyrosine-type recombinase/integrase	A0A2H4JFF0	uncultured_Caudovirales_phage	1.4e-173	77.5
WP_015900785.1\|1555514_1557137_-	chaperonin GroEL	A0A240F779	uncultured_virus	9.9e-157	53.0
1555491:1555504	attR	NA	NA	NA	NA
WP_015900786.1\|1557178_1557463_-	co-chaperone GroES	A0A221S4A8	uncultured_virus	8.9e-13	37.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage