CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_017336	Staphylococcus aureus subsp. aureus ST398 plasmid pS0385-3, complete sequence	0 crisprs	NA	0	0	0	0
NC_017334	Staphylococcus aureus subsp. aureus ST398 plasmid pS0385-1, complete sequence	0 crisprs	NA	0	0	0	0
NC_017335	Staphylococcus aureus subsp. aureus ST398 plasmid pS0385-2, complete sequence	0 crisprs	NA	0	0	0	0
NC_017333	Staphylococcus aureus subsp. aureus ST398, complete genome	13 crisprs	csa3,cas3,DEDDh,DinG,TnsE_C,WYL	6	5	13	2

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_017333_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_1

315263-315462

Orphan

Consensus_repeat	Method
TGCAAGTTGGCGGGGCCCCAACACAGAAGCT	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_017333_1

>merge|NC_017333|1|315263-315462|CRISPRCasFinder
GTTATATTGGCGGATCCCCAACACAGAAGCTGGCGAAAATACAGCTTACAATAATGTGCGAGTTGGCAGGCCTCCAACACAGAGAAATTGGAACAGCAATTTCTACAGACAATGCAAGTTGGCGGGGCCCCAACACAGAAGCTAGCGAAAAGTCAGCTTACAATAATGTGCAAGTTGGCGGGGGCCCCAACACAGAAGCT

>NC_017333|1|1|315263-315462|CRISPRCasFinder
GTTATATTGGCGGATCCCCAACACAGAAGCT	GGCGAAAATACAGCTTACAATAATG
TGCGAGTTGGCAGGCCTCCAACACAGAGAAA	TTGGAACAGCAATTTCTACAGACAA
TGCAAGTTGGCGGGGCCCCAACACAGAAGCT	AGCGAAAAGTCAGCTTACAATAATGT
GCAAGTTGGCGGGGGCCCCAACACAGAAGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_000736798.1\|324087_325038_+\|glycine-glycine-endopeptidase-LytM	unknown	unknown	gnl\|CDD\|226451
NC_017333.1\|WP_000975356.1\|302709_304431_+\|poly(ribitol-phosphate)-beta-N-acetylglucosaminyltransferase	unknown	unknown	gnl\|CDD\|376098
NC_017333.1\|WP_000757874.1\|319259_320258_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_017333.1\|WP_000570073.1\|325089_325749_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_017333.1\|WP_000750483.1\|317727_318132_-\|D-ribose-pyranase	unknown	unknown	gnl\|CDD\|183318
NC_017333.1\|WP_000029208.1\|318146_319028_-\|ribose-transporter-RbsU	unknown	unknown	gnl\|CDD\|284268
NC_017333.1\|WP_000337367.1\|322769_323762_+\|linear-amide-C-N-hydrolase	unknown	unknown	gnl\|CDD\|225591
NC_017333.1\|WP_000950281.1\|305495_307250_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NC_017333.1\|WP_001066542.1\|321159_322536_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_017333.1\|WP_000182750.1\|316785_317700_-\|ribokinase	unknown	unknown	gnl\|CDD\|274000
NC_017333.1\|WP_000164008.1\|313760_315197_+\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|181973
NC_017333.1\|WP_000062646.1\|309583_311875_+\|cbb3-type-cytochrome-c-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|225795
NC_017333.1\|WP_000607067.1\|308541_309243_+\|antiholin-like-protein-LrgB	unknown	unknown	gnl\|CDD\|179810
NC_017333.1\|WP_001159764.1\|320638_321031_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000608834.1\|304574_305249_+\|iron-sulfur-cluster-repair-di-iron-protein-ScdA	unknown	unknown	gnl\|CDD\|183940
NC_017333.1\|WP_000645457.1\|307252_307993_+\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|184495
NC_017333.1\|WP_000922329.1\|312100_312805_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_017333.1\|WP_000031255.1\|315772_316534_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_017333.1\|WP_001792906.1\|308105_308549_+\|antiholin-like-murein-hydrolase-modulator-LrgA	unknown	unknown	gnl\|CDD\|235222
NC_017333.1\|WP_000066924.1\|312953_313745_+\|PTS-glucose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|225101

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_000736798.1\|324087_325038_+\|glycine-glycine-endopeptidase-LytM	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.47845e-32
NC_017333.1\|WP_000975356.1\|302709_304431_+\|poly(ribitol-phosphate)-beta-N-acetylglucosaminyltransferase	gnl\|CDD\|376098	pfam18674, TarS_C1, TarS beta-glycosyltransferase C-terminal domain 1. Beta-glycosyltransferase TarS is an enzyme responsible for the glycosylation of wall teichoic acid polymers of the S. aureus cell wall, a process that has been shown to be specifically responsible for methicillin resistance in MRSA. It contains a trimerization domain composed of tandem carbohydrate binding motifs.The two C-terminally localized regions composed of a series of beta-sheets participate in an extensive trimerization interface and they assume an immunoglobulin-like fold. It is suggested that both carbohydrate binding domains may be involved in polyRboP binding, however unlike pullulanase, the CBMs of TarS are involved in the formation of an extensive trimerization interface.	8.99017e-35
NC_017333.1\|WP_000757874.1\|319259_320258_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	7.74259e-99
NC_017333.1\|WP_000570073.1\|325089_325749_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.1821e-66
NC_017333.1\|WP_000750483.1\|317727_318132_-\|D-ribose-pyranase	gnl\|CDD\|183318	PRK11797, PRK11797, D-ribose pyranase; Provisional.	4.08879e-70
NC_017333.1\|WP_000029208.1\|318146_319028_-\|ribose-transporter-RbsU	gnl\|CDD\|284268	pfam06800, Sugar_transport, Sugar transport protein. This is a family of bacterial sugar transporters approximately 300 residues long. Members include glucose uptake proteins, ribose transport proteins, and several putative and hypothetical membrane proteins probably involved in sugar transport across bacterial membranes. These members are transmembrane proteins which are usually 5+5 duplications. This model recognizes a set of five TMs,.	1.263e-116
NC_017333.1\|WP_000337367.1\|322769_323762_+\|linear-amide-C-N-hydrolase	gnl\|CDD\|225591	COG3049, COG3049, Penicillin V acylase and related amidases [Cell envelope biogenesis, outer membrane].	2.86355e-151
NC_017333.1\|WP_000950281.1\|305495_307250_+\|sensor-histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	0
NC_017333.1\|WP_001066542.1\|321159_322536_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.94981e-30
NC_017333.1\|WP_000182750.1\|316785_317700_-\|ribokinase	gnl\|CDD\|274000	TIGR02152, Putative_ribokinase, ribokinase. This model describes ribokinase, an enzyme catalyzing the first step in ribose catabolism. The rbsK gene encoding ribokinase typically is found with ribose transport genes. Ribokinase belongs to the carbohydrate kinase pfkB family (pfam00294). In the wide gulf between the current trusted (360 bit) and noise (100 bit) cutoffs are a number of sequences, few of which are clustered with predicted ribose transport genes but many of which are currently annotated as if having ribokinase activity. Most likely some have this function and others do not. [Energy metabolism, Sugars].	1.07143e-143
NC_017333.1\|WP_000164008.1\|313760_315197_+\|6-phospho-beta-glucosidase	gnl\|CDD\|181973	PRK09589, celA, 6-phospho-beta-glucosidase; Reviewed.	0
NC_017333.1\|WP_000062646.1\|309583_311875_+\|cbb3-type-cytochrome-c-oxidase-subunit-I	gnl\|CDD\|225795	COG3256, NorB, Nitric oxide reductase large subunit [Inorganic ion transport and metabolism].	4.75392e-179
NC_017333.1\|WP_000607067.1\|308541_309243_+\|antiholin-like-protein-LrgB	gnl\|CDD\|179810	PRK04288, PRK04288, antiholin-like protein LrgB; Provisional.	5.86643e-124
NC_017333.1\|WP_000608834.1\|304574_305249_+\|iron-sulfur-cluster-repair-di-iron-protein-ScdA	gnl\|CDD\|183940	PRK13276, PRK13276, iron-sulfur cluster repair di-iron protein ScdA.	8.35569e-154
NC_017333.1\|WP_000645457.1\|307252_307993_+\|DNA-binding-response-regulator	gnl\|CDD\|184495	PRK14084, PRK14084, DNA-binding response regulator.	7.57134e-152
NC_017333.1\|WP_000922329.1\|312100_312805_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	3.76404e-62
NC_017333.1\|WP_000031255.1\|315772_316534_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.95473e-27
NC_017333.1\|WP_001792906.1\|308105_308549_+\|antiholin-like-murein-hydrolase-modulator-LrgA	gnl\|CDD\|235222	PRK04125, PRK04125, antiholin-like protein LrgA.	8.44339e-64
NC_017333.1\|WP_000066924.1\|312953_313745_+\|PTS-glucose-transporter-subunit-IIA	gnl\|CDD\|225101	COG2190, NagE, Phosphotransferase system IIA components [Carbohydrate transport and metabolism].	4.11077e-54

>NC_017333.1|WP_000164008.1|313760_315197_+|6-phospho-beta-glucosidase
MTKLPQSFMWGGALAANQFEGGYDKGGKGLSVIDVMTSGAHGKARQITESIDPNHYYPNHEGIDFYHRYKEDIALFKEMGLKCLRTSIAWTRIFPNGDEDVPNEEGLAFYDRIFDELIAQGIEPVVTLSHFEMPLHLAKHYGGFRNREVVDYFVHFARVVFERYKDKVTYWMTFNEINNQMDTSNPIFLWTNSGVALTENDNPEEVLYQVAHHELLASALAVRLGKEINPKFKIGTMISHVPIYPYSCHPKDMMEAQIANRLRFFFPDVQVRGYYPSYAKKMLARKGYDVGWQEGDDSILQQGTVDYIGFSYYMSTAVKHDVNTTVENNIVNGGLNHSVENPHIATSDWGWAIDPDGLRYTLNVLYDRYQLPLFIVENGFGAVDEVVDGHIHDDYRIEYLKAHITAAIEAVDQDGVDLIGYTPWGIIDIVSFTTGEMKKRYGLIYVDRDNDGHGTMERLKKDSFYWYQQVIASNGDKL
>NC_017333.1|WP_000066924.1|312953_313745_+|PTS-glucose-transporter-subunit-IIA
MSNKYKDQAQDILTAVGGVENIVDVSYDTVRMTIHMHHAIPSTANEVTQIDGVASVDENETQLVIVFNEEVKYVYQQLQLLMDDAKHQEDTNHDAVDTQETEQKAQAKVTTPILVKAPIAGRRILLKEVRDSIFREKMVGEGLAIKAHKEFKVIAPFSGKVSMIVPTKHAVGIQSEDGVDIVIHIGVNTVDLEGKGFKCFVKQNDRVEAGQTLLQFDQQYIQEQGYNSDVIVVISNSSDFNKVELTMNEIITTEDVIFKIFKN
>NC_017333.1|WP_000922329.1|312100_312805_-|GntR-family-transcriptional-regulator
MLKYEHIAKQLNAFIHQSNFKPGDKLPSVTQLKERYQVSKSTIIKALGLLEQDGLIYQAQGSGIYVRNIADANRINVFKTNGFSKSLGEHRMTSKVLVFKEIATPPKSVQDELQLNADDTVYYLERLRFVDDDVLCIEYSYYHKEIVKYLNDDIAKGSIFDYLESNMKLRIGFSDIFFNVDQLTSSEASLLQLSTGEPCLRYHQTFYTMTGKPFDSSDIVFHYRHAQFYIPSKK
>NC_017333.1|WP_000062646.1|309583_311875_+|cbb3-type-cytochrome-c-oxidase-subunit-I
MSMQSSYKRLVKVLLTILVIVFSILLVGGWYIFKNEAPRPTKIVDQQGHTLVTKGELISGQAIYEKYGLTDYGSYLGNGSYLGPDYTAEALHHYLIGMRKYYAQDIYHKQLHKLNHVEIAVVKDKVMKEIRINRYSEKEDQLVLTPGQVYGLKYLQDYYKKEFVNNPKQVGLNENMIKQFQNDDYMVAGNKIEHLSQFFFWGAWLSSTDRPGKTFSYTNNWPYDVDAGNTLPSAGILWTAISVTLLIAGLAFIIYIQKRYEFDMKPTYESERELPKIEVDSKITDSQRKVGKYLVVVMLLFLVQILLGELLAHYYVENKFFGIEIQRLFPFNIVKTWHVQLVIFWVATTWLAAGIYIVPKVLGNEPKKQGVLVDILFWALIIVVMGSMIGEWSHILGWIDSHWWLFGHFGWEYIELGKFWQILFIVGMVLWVIILCRGFLPAIRNKVQVNHDKRHLLTLLFVGAIAIPLFYLASLFIMPNSHVTFADYWRWWIVHLWVEGIFEAFAVVLIGFLMVNMKLTTIETTIRALYFQLILLLGTGIVGMGHHYYWQGDHSIWLALGSCFSALEVVPLCLLIWEAYTHYRLYKKSDIAFPYKGTFIFLASTGLWNAIGAGALGFLINTPAVNYFEHGTQWTAAHAHGSMAGVYGMFSIAIALYVFKNITKKEFWTPKVEKWIKISCWALNVGLAGMVFVTLIPVGYIQLKDGLEDGYWHSRLTSFYEQPLVKAIMWGRMPWDIIFTVGVIILVVIFIRGYRHLKPKYRV
>NC_017333.1|WP_000607067.1|308541_309243_+|antiholin-like-protein-LrgB
MINHLALNTPYFGILLSVIPFFLATILFEKTNRFFLFAPLFVSMVFGVAFLYLTGIPYKTYKIGGDIIYFFLEPATICFAIPLYKKREVLVKHWHRIIGGIGIGTVVALLIILTFAKLAQFANDVILSMLPQAATTAIALPVSAGIGGIKELTSLAVILNGVIIYALGNKFLKLFRITNPIARGLALGTSGHTLGVAPAKELGPVEESMASIALVLVGVVVVAVVPVFVAIFF
>NC_017333.1|WP_001792906.1|308105_308549_+|antiholin-like-murein-hydrolase-modulator-LrgA
MVVKQQKDASKPAHFFHQVIVIALVLFVSKIIESFMPIPMPASVIGLVLLFVLLCTGAVKLGEVEKVGTTLTNNIGLLFVPAGISVVNSLGVISQAPFLIIGLIIVSTILLLICTGYVTQIIMKVTSRSKGDKVTKKIKIEEAQAHD
>NC_017333.1|WP_000645457.1|307252_307993_+|DNA-binding-response-regulator
MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDENGIELGAKIQKMKEPPAIIFATAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKAKDDNSASTIANDMSANFDQSLPVEIDDKIHMLKQQNIIGIGTHNGITTIHTTNHKYETTEPLNRYEKRLNPAYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFKASIGLL
>NC_017333.1|WP_000950281.1|305495_307250_+|sensor-histidine-kinase
MLSLTMLLLERVGLIIILAYVLMNIPYFKNLMNRRRTWKARWQLCIIFSLFALMSNLTGIVIDHQHSLSGSVYFRLDDDVSLANTRVLTIGVAGLVGGPFVGLFVGVISGIFRVYMGGADAQVYLISSIFIGIIAGYFGLQAQRRKRYPSIAKSAMIGIVMEMIQMLSILTFSHDKAYAVDLISLIALPMIIVNSVGTAIFMSIIISTLKQEEQMKAVQTHDVLQLMNQTLPYFKEGLNRESAQQIAMIIKNLMKVSAVAITSKNEILSHVGAGSDHHIPTNEILTSLSKDVLKSGKLKEVHTKEEIGCSHPNCPLRAAIVIPLEMHGSIVGTLKMYFTNPNDLTFVERQLAEGLANIFSSQIELGEAETQSKLLKDAEIKSLQAQVSPHFFFNSINTISALVRINSEKARELLLELSYFFRANLQGSKQHTITLDKELSQVRAYLSLEQARYPGRFNININVEDKYRDVLVPPFLIQILVENAIKHAFTNRKQGNDIDVSVIKETATHVRIIVQDNGQGISKDKMHLLGETSVESESGTGSALENLNLRLKGLFGKSAALQFESTSSGTTFWCVLPYERQEEE
>NC_017333.1|WP_000608834.1|304574_305249_+|iron-sulfur-cluster-repair-di-iron-protein-ScdA
MINKNDIVADVVTDYPKAADIFRSVGIDFCCGGQVSIEAASLEKKNVDLNELLQRLNEVEQTNTPGSLNPKFLNVSSLIQYIQAAYHEPLREEFKNLTPYVTKLSKVHGPNHPYLVELKETYDTFKNGMLEHMQKEDDVDFPKLIKYEQGEVVDDINTVIDDLVSDHIATGQLLVKMSDLTSSYEPPIEACGTWRLVYQRLKALEVLTHEHVHLENHVLFKKVS
>NC_017333.1|WP_000975356.1|302709_304431_+|poly(ribitol-phosphate)-beta-N-acetylglucosaminyltransferase
MMKFSVIVPTYNSEKYITELLNSLAKQDFPKTEFEVVVVDDCSTDQTLQIVEKYRNKLNLKVSQLETNSGGPGKPRNVALKQAEGEFVLFVDSDDYINKETLKDAAAFIDEHHSDVLLIKMKGVNGRGVPQSMFKETAPEVTLLNSRIIYTLSPTKIYRTALLKDNDIYFPEELKSAEDQLFTMKAYLNANRISVLSDKAYYYATKREGEHMSSAYVSPEDFYEVMRLIAVEILNADLEEAHKDQILAEFLNRHFSFSRTNGFSLKVKVEDQPQWINALGDFIQAVPVRVDALVMSKLRPLLHYARAKDIDNYRTVEESYRQGQYYRFDIVDGKLNIQFNEGEPYFEGIDIAKPKVKMTAFKFDNHKIVTELTLNEFMIGEGQYDVRLKLHSRNKKHTMYVPLSVNANKQYRFNIMLEDIKAYLPKEKIWDVFLEVQIGTEVFEVRVGNQRNKYAYTAETSALIHLNNDFYRLTPYFTKDFNNISLYFTAITLTDSISMKLKGKNKIILTGLDRGYVFEEGMASVVLKDDMVMGMLSQTSENEVQILLSKDIKKRDFKNIVKLNTAHMTYSLK
>NC_017333.1|WP_000031255.1|315772_316534_-|class-I-SAM-dependent-methyltransferase
MSKEAGHTFLAKLGKTRLRPGGKAATDWLIQQGAFSQDKHVLEVACNMCTTSIYLAHTYGCHIQGVDINKKALEKAQENISAAGLESYIQVQQANAVKLPFDDNQFDIVLNEAMLTMLPIAIKEKALREYYRVLKPGGILLTHDIVIVNESHATHVVKSLSAAINVNVSPQTKLGWLDLYHQAGFNHVHYHTGPMSLMTPKGLIYDEGIVGTIKIINNALKKENRPMFCKMFKTMTRLRKDMNYITFVAKKEH
>NC_017333.1|WP_000182750.1|316785_317700_-|ribokinase
MTNKVVILGSTNVDQFLTVERYAQPGETLHVEEAQKAFGGGKGANQAIATARMQADTTFITKIGTDGVADFILEDFKAAHIDTSYIIKTTEEKTGQAFITVNAEGQNTIYVYGGANMTMTPEDVINAKDAIINADFVVAQLEIPIPAIISAFEIAKAHGVTTVLNPAPAKALPNELLSLIDIIVPNETEAELLSGIKVTNEQSMKDNANYFLSLGIKTVLITLGKQGTYFATKNQSQHIEAYKVNAIDTTAAGDTFIGAFVSRLNKSQDNLADAIDFGNKASSLTVQKHGAQASIPLLEEVNQV
>NC_017333.1|WP_000750483.1|317727_318132_-|D-ribose-pyranase
MKKTAVLNEHISKAIATIGHFDLLTINDAGMPIPNDHRRIDLAVTKNLPRFIDVLATVLEEMEIQKIYLAEEIKEHNPTQLQQIKQLISSEIEIIFIPHEEMKSNLAHPLNKGNIRTGETTPYSNIALESNVTF
>NC_017333.1|WP_000029208.1|318146_319028_-|ribose-transporter-RbsU
MSIVALLIGLGPLIGWGFFPTVASKFGGKPVHQIIGATVGTLIFAIILAVVTSSGFPTGTNLLFALLSGAGWGFGQIITFKAFELVGSSRAMPVTTAFQLLGASLWGVFALGNWPGIGHRIIGFTALVVILIGARMTVWSERKEASNAKNLRRAVVLLLIGEFGYWLYSAAPQATSIDGLTAFLPQAMGMVIVAVIYGFMNMKAENPFRNKITWLQIISGFFFAFGALTYLISAQPNMNGLATGFILSQTSVVLATLTGIYFLKQHKTSKEMVITIIGLVLILVAASVTVFIK
>NC_017333.1|WP_000757874.1|319259_320258_-|LacI-family-DNA-binding-transcriptional-regulator
MKKVSIKDVAREAGVSVTTVSHILNHNDSRFSATTIKNVHAVSECLGYAPNKHAKQLRGSKIQTIGVILPSLTNPFFSALMQSIHDHKPSDVDLCFLTSTATDLYDNIKHLIDRGIDGLIIAQYISSPDALNNYLKKHHVPYVVLDQNDHQGYTDFVRTNEYQGGQLAAQHLIELGHNNMMIVAPYDMMANMSTRVTGFVDTLRANQLPEPQIVHTELSKRGGLTIVDDIMVQSATAIFAINDELAIGILRGLIEHGISIPKDISLIGYDDIDYAAYVSPPLTTVAQPITDIGKTSLTLLLQRLQHLDKSIDMIELPTTLKIRATTGYHLSN
>NC_017333.1|WP_001159764.1|320638_321031_+|hypothetical-protein
MQFKLKEEEIISFLELKYPEKEFEYGRLLVGQHKRDDLDVYYFGDTFLMCTIISFKTFEIKETVELSYDAVNRIVLKDGWLFRKMRIETMQKVLKYGTSKLMLTDFQKDNYNKYIQGQKQRVIFENGHFV
>NC_017333.1|WP_001066542.1|321159_322536_-|MFS-transporter
MNNTQSSPRSNIIIAIMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILLLKGTPEKVSQHSHRHPFDYKGMSIFAVMIGSFTLLLTQGFEQGWFSTFSFICLSIIIITTLIFIIIERRHEVPFIDFSVLRNRPFIGAFLNNFVLNSGLGVTVVFFIYAQTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGPLFPVIGITIISMTSLQPSQYIIAVVIGFVICAIGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFGIALSTTVFSMLQLNYAPSVAATITFIVSIVLMILGSLSAYMIIPKTVKS
>NC_017333.1|WP_000337367.1|322769_323762_+|linear-amide-C-N-hydrolase
MCTGFTIQTLNNQVLLGRTMDYDYPLDGSPAVTPRNYRWTSRTGTTGQTQYGFIGTGTDMEGFIYGDGVNEHGVAISTQYFRGYSSYGSIHKADAMNITQNEIVTWILGYTTSIEDMKQQASQIHVVAVYLNDIGEVPPLHYHVSDATGHSVEVSFKEGEVVIKDNPIGVLTNHPDLDWHYSNLRQYINISPYPAPANLLEGVTIEPLGNEAGTFGLPGGFTSTERFVRMAFMKANIAQNNDKEMDLMNAFYLLDAVNIPIGIVRPHDADNHYTMYQTVINLTTRTLYIKYYGSNEIVALKLTDDLINRKDMTIFKPEKHITIRKLNDNQ
>NC_017333.1|WP_000736798.1|324087_325038_+|glycine-glycine-endopeptidase-LytM
MKKLTAAAIATMGFATFTMAHQADAAETTNTQQAHTQMSTQSQDVSYGTYYTIDSNGDYHHTPDGNWNQAMFDNKEYSYTFVDAQGHTHYFYNCYPKNANANGSGQTYVNPATAGDNNDYTASQSQQHINQYGYQSNVGPDASYYSHSNNNQAYNSHDGNGKVNYPNGTSNQNGGSASKATASGHAKDASWLTSRKQLQPYGQYHGGGAHYGVDYAMPENSPVYSLTDGTVVQAGWSNYGGGNQVTIKEANSNNYQWYMHNNRLTVSAGDKVKAGDQIAYSGSTGNSTAPHVHFQRMSGGIGNQYAVDPTSYLQSR
>NC_017333.1|WP_000570073.1|325089_325749_-|ABC-transporter-ATP-binding-protein
MIEINNLSKRYRNKQIFNHLTMSFDSNRLTVLLGDNGAGKSTLLRMIAGIEKANDGTINYFGEKWNQRQIQNHIGYVPQDIALFEHMTVAENIKFFKSLCKNSINDTTINEYLQQLNFNDTSAKVSTLSGGNKRKINILVGLLGQPRILILDEPTVGIDLKSRHDIHQLLNIMKSKCLIILTTHHLDEVEALADDIKLIGQDPFYQHVLEDKQWAYTYY

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Crispr_ID: NC_017333_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_2

724389-724497

Orphan

Consensus_repeat	Method
AAAGGAACGCAGTTGGATGCTACCGCACAACTGCATAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017333_2

>merge|NC_017333|2|724389-724497|CRISPRCasFinder
AAAGGAACGCAGTTGGATGCTACCGCACAACTGCATAAAAGCCTCTAATCACTAGAGTTCAAGAGGCTTTAAAGGAACGCAGTTGGATGCTACCGCACAACTGCATAAA

>NC_017333|2|2|724389-724497|CRISPRCasFinder
AAAGGAACGCAGTTGGATGCTACCGCACAACTGCATAAA	AGCCTCTAATCACTAGAGTTCAAGAGGCTTT
AAAGGAACGCAGTTGGATGCTACCGCACAACTGCATAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_000362963.1\|727294_728095_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_017333.1\|WP_000359090.1\|721168_721585_+\|DUF1934-domain-containing-protein	unknown	unknown	gnl\|CDD\|226896
NC_017333.1\|WP_000735556.1\|728230_728737_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_021285860.1\|732145_733075_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|225778
NC_017333.1\|WP_000749060.1\|724548_725436_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238563
NC_017333.1\|WP_000477504.1\|717024_717501_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_017333.1\|WP_000180233.1\|717540_718836_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224004
NC_017333.1\|WP_000901759.1\|723583_724219_+\|endonuclease-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|225140
NC_017333.1\|WP_001045424.1\|729783_730572_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_017333.1\|WP_000633790.1\|716318_716855_+\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NC_017333.1\|WP_001200750.1\|719882_720893_+\|alcohol-dehydrogenase-AdhP	unknown	unknown	gnl\|CDD\|181842
NC_017333.1\|WP_001222139.1\|728898_729615_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000365352.1\|726591_727311_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NC_017333.1\|WP_000923047.1\|714038_714665_+\|DUF443-domain-containing-protein	unknown	unknown	gnl\|CDD\|335700
NC_017333.1\|WP_001021133.1\|721581_723243_+\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234964
NC_017333.1\|WP_016187113.1\|718863_719385_+\|YwhD-family-protein	unknown	unknown	gnl\|CDD\|378039
NC_017333.1\|WP_010922824.1\|725586_726537_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_017333.1\|WP_001018677.1\|730823_731198_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|130944
NC_017333.1\|WP_000169038.1\|733267_733492_-\|DUF2922-domain-containing-protein	unknown	unknown	gnl\|CDD\|378571
NC_017333.1\|WP_000808883.1\|714934_715873_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381309

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_000362963.1\|727294_728095_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.7852e-26
NC_017333.1\|WP_000359090.1\|721168_721585_+\|DUF1934-domain-containing-protein	gnl\|CDD\|226896	COG4506, COG4506, Uncharacterized protein conserved in bacteria [Function unknown].	6.10844e-58
NC_017333.1\|WP_021285860.1\|732145_733075_-\|DMT-family-transporter	gnl\|CDD\|225778	COG3238, COG3238, Uncharacterized protein conserved in bacteria [Function unknown].	6.43292e-34
NC_017333.1\|WP_000749060.1\|724548_725436_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238563	cd01143, YvrC, Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.	1.04955e-72
NC_017333.1\|WP_000477504.1\|717024_717501_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.13315e-11
NC_017333.1\|WP_000180233.1\|717540_718836_+\|HD-domain-containing-protein	gnl\|CDD\|224004	COG1078, COG1078, HD superfamily phosphohydrolases [General function prediction only].	3.99954e-151
NC_017333.1\|WP_000901759.1\|723583_724219_+\|endonuclease-III-domain-containing-protein	gnl\|CDD\|225140	COG2231, COG2231, Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair].	5.92839e-91
NC_017333.1\|WP_001045424.1\|729783_730572_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.07146e-34
NC_017333.1\|WP_000633790.1\|716318_716855_+\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	1.37974e-25
NC_017333.1\|WP_001200750.1\|719882_720893_+\|alcohol-dehydrogenase-AdhP	gnl\|CDD\|181842	PRK09422, PRK09422, ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional.	0
NC_017333.1\|WP_000365352.1\|726591_727311_+\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	5.71997e-38
NC_017333.1\|WP_000923047.1\|714038_714665_+\|DUF443-domain-containing-protein	gnl\|CDD\|335700	pfam04276, DUF443, Protein of unknown function (DUF443). Family of uncharacterized proteins.	2.78629e-57
NC_017333.1\|WP_001021133.1\|721581_723243_+\|arginine--tRNA-ligase	gnl\|CDD\|234964	PRK01611, argS, arginyl-tRNA synthetase; Reviewed.	0
NC_017333.1\|WP_016187113.1\|718863_719385_+\|YwhD-family-protein	gnl\|CDD\|378039	pfam08741, YwhD, YwhD family. This family of proteins are currently uncharacterized. They are around 170 amino acids in length.	5.69328e-97
NC_017333.1\|WP_010922824.1\|725586_726537_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	6.43614e-48
NC_017333.1\|WP_001018677.1\|730823_731198_-\|transcriptional-regulator	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	1.77309e-26
NC_017333.1\|WP_000169038.1\|733267_733492_-\|DUF2922-domain-containing-protein	gnl\|CDD\|378571	pfam11148, DUF2922, Protein of unknown function (DUF2922). This bacterial family of proteins has no known function.	3.83351e-14
NC_017333.1\|WP_000808883.1\|714934_715873_+\|aldo/keto-reductase	gnl\|CDD\|381309	cd19083, AKR_AKR11A1_11D1, AKR11A and AKR11D families of aldo-keto reductase (AKR). Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).	1.23356e-168

>NC_017333.1|WP_000901759.1|723583_724219_+|endonuclease-III-domain-containing-protein
MLGTDELYKLLYRHMGPQNWWPADNDIEMMLGAILVQNTRWRNAEIALNQIKEHTHFNPNHILELPIETLQSLIRPSGFYKSKSLTIKTLLTWLARHHFNYQEINERYKAELRKELLTLKGIGSETADVLLVYIFERIEFIPDSYTRKIYNKLGYENTKSYDQLKKVITLPNHFTNQDANEFHALLDVFGKHYFRDKDIKNYDFLEPYFKK
>NC_017333.1|WP_001021133.1|721581_723243_+|arginine--tRNA-ligase
MNIIDQVKQTLVEEIAASINKAGLADEIPDIKIEVPKDTKNGDYATNIAMVLTKIAKRNPREIAQAIVDNLDTEKAHVKQIDIAGPGFINFYLDNQYLTAIIPEAIEKGDQFGHVNESKGQNILLEYVSANPTGDLHIGHARNAAVGDALANILTAAGYNVTREYYINDAGNQITNLARSIETRFFEALGDNSYSMPEDGYNGKDIIEIGKDLAEKHPEIKDYSEEARLKEFRKLGVEYEMAKLKNDLAEFNTHFDNWFSETSLYEKGEILEVLAKMKELGYTYEADGATWLRTTDFKDDKDRVLIKNDGTYTYFLPDIAYHFDKVKRGNDILIDLFGADHHGYINRLKASLETFGVDSNRLEIQIMQMVRLMENGKEVKMSKRTGNAITLREIMDEVGVDAARYFLTMRSPDSHFDFDMELAKEQSQDNPVYYAQYAHARICSILKQAKEQGIEVAAANDFTTITNEKAIELLKKVADFEPTIESAAEHRSAHRITNYIQDLASHFHKFYNAEKVLTDDIVKTKAHVAMIEAVRITLKNALAMVGVSAPESM
>NC_017333.1|WP_000359090.1|721168_721585_+|DUF1934-domain-containing-protein
MDKKVSIYTKQVLKQHNEKEKFEFTTEGTWQQRQSNFIRYVEQIEDATVNVTIKVDDDSVKLIRKGDINMNLHFVEGQATTTFYDISAGRIPLEVKTLRILHFVSGDGGKLKIHYELYQDNEKMGSYQYEINYKEIGE
>NC_017333.1|WP_001200750.1|719882_720893_+|alcohol-dehydrogenase-AdhP
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADVIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
>NC_017333.1|WP_016187113.1|718863_719385_+|YwhD-family-protein
MEVISLSEKKGFNFNIIKNDPLDGHKGTNIGSISLDNIAPVFIDVANKEAFIDIGGMHARAKVEKGVKWITDKAAVEGDEAKEYWLCWVTTERNEQGPYYAGLTACYLLVNKAIRRGYKSMPEHVNMMDKSMKHHIIIDQIGDENKVILKDFLMNHDEGMWKHSSDALHQAFN
>NC_017333.1|WP_000180233.1|717540_718836_+|HD-domain-containing-protein
MTNAYVDLKLVEEKVFKDPIHRYIHVEDQLIWDLIKTKEFQRLRRIRQLGTLYLSFHTAEHSRFGHSLGVYEIVRRLIDESFIGHDAWDNKDRPLALCAALLHDLGHGPFSHSFEKIFNTDHEAYTQAIITGDTEVNAVLRKVSPEFPREVAEVINKTHHNKLVISMISSQIDADRMDYLQRDAYFTGVSYGAFDMERILRLMRPSKDEVLIKESGMHAVENFIMSRYQMYWQIYFHPVSRGGEVLLNNCLKRAKQLYNEGYEFKLHPHDFIPFFEETVTIEQYVELDEAVVTYYLEKWTKEDDAILSDLASRFINRDLFKYIPFDGSIITISELQELFEAGGINPDYYFVSEAFSDLPYDYDRPGSNRKPIHLLRQDGKIREISNQSLVIHSITGINRQDYKLYYPREMVAKIKDKTIREAIENLINELN
>NC_017333.1|WP_000477504.1|717024_717501_+|GNAT-family-N-acetyltransferase
MFKVRQATEKDVVQIRDVATKAWFNTYLNIYAATTVNHLLEASYNEHHLKKRLQEQLFLVVEEGNDIVGFANFIYGEELYLSAHYVKPESQHTGYGTALLNEGLSRFEDKFEGVYLEVDNKNEEAVAYYKEQGFTILRSYEPEMYGEKLDLALMYKAF
>NC_017333.1|WP_000633790.1|716318_716855_+|flavodoxin-family-protein
MITVLFGGSRPNGNTAQLTKFALQGLDYQWIDVTQHRFKPIRDVRHIEESITDYEDDYQEILDKVLASDTIIFASPVYWYSISAPLKAFIEHWSETLQDKRYPNFKAQMAEKDFRVILVGGDCPKIKAKPAITQMKYSLDFLGATLNGYIIGTANKPGDIMKDNYALARATEWNQLLQ
>NC_017333.1|WP_000808883.1|714934_715873_+|aldo/keto-reductase
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINFLDTAYIYGPERSEELVGEVVKEYPREQIKIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDDNTPKDQAVAALQELKEQGKIKAIGVSNFTLDQLKEANKDGYVDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLASGILAGKYDENTKFSDHRTTRRDFKPGVFEENVRRVNALEKIAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVIENIKAADIVLSKDEIQYIDELFPIED
>NC_017333.1|WP_000923047.1|714038_714665_+|DUF443-domain-containing-protein
MLLCESKIINKNPKYRIIKYNDEYLMVDIISTWISLFFPFINWFIPKRYVKISKEDFENLNIVKPAKKNVFWPVAGISALFAVTLRKYTHLLDTQLDKKLVIAICCITFIGILIFYVRLIKKSSLNIYNPKNERSKIILIPTLKNFCFTLFGYILFGGLTMLFLDALLSMSHQNIIVYFTWIAVIMGFFLVNIALIIDKNIYVILKNQ
>NC_017333.1|WP_000749060.1|724548_725436_+|ABC-transporter-substrate-binding-protein
MKKSLIAFILIFMLVLSGCGMKDNDKQSSDDNGSSKSPYHRIVSLMPSNTEILYELGLGKYIVGVSTVDDYPKDVKKGKKQFDALNLNKEELLKAKPDLILAHESQKATANKVLSSLEKQGIKVVYVKDAQSIDETYNTFKQIGKLTHHDKQAEQLVEETKDNIDKVIDSIPAHHKKSKVFIEVSSKPEIYTAGKHTFFNDMLEKLEAQNVYSDINGWNPVTKESIIKKNPDILISTEAKTRSDYMDIIKKRGGFNKINAVKNTRIEVVNGDEVSRPGPRIDEGLKELRDAIYRK
>NC_017333.1|WP_010922824.1|725586_726537_+|iron-ABC-transporter-permease
MTFNKVLLSWIVILIITTSIYLFWQLGDINDVFNQSILINVRLPRLLEALLTGMILTVAGLIFQTVLNNALADSFTLGLASGATFGSGLALFLGLTTLWIPVFSITFSLITLITVLVITSVLSQGYPVRILILSGLMIGALFNSLLYFLILLKPRKLNTIANYLFGGFGDAEYSNVSIIAITFIIALFGIFIILNQLKLLQLGELKSQSLGLNVQLITYIALCIASMITAINVAYVGIIGFIGMVIPQLIRKWQWKQSLGRQLALNIVIGGQIMVMADFIGSHILSPVQIPASIIIALIGIPVLFYMLISQSKRLH
>NC_017333.1|WP_000365352.1|726591_727311_+|HAD-family-hydrolase
MDLNQIKAVVFDLEGTLLDRVKSREKFIEEQYERFHDYLIHVQLADFKKAFIELDDDEDNDKPDLYKEIIKRFHVDRLTWKDLFNDFEMHFYRYVFPYYDTLYTLEKLSQKGFQIGVIANGKSKIKQFRLHSLGLMHVINYLSTSETVGFRKPHPKIFEDMIDQLGVLPEQIMYVGDDALNDVAPARAMGMVSVWYKQEDAEIEPLEEEVDFTITTVEELLTILPIKIDNKGENYGSIY
>NC_017333.1|WP_000362963.1|727294_728095_+|alpha/beta-hydrolase
MDLFTRKDGTSIHYSTLGEGYPIVLIHTVLDNYSVFNKLAAELAKSFQVVLIDLRGHGYSDKPRHIEIKDFSDDIVELLKYLYIEEVAFVCHEMGGIIGADISVRYPEFTSSLMLVNPTSIEGELPEERLFRKYAHIIRNWDPEKQDKFLNKRKYYRPRKMNRFLKHVVDTNEISTKEEIQAVKEVFKNADISQTYRNVVVPTKIIAGEFGERTTRLEAKEVADLIQNADFEVYQESSAFPFVEEQERFVEDTAAFINKHHDEKHV
>NC_017333.1|WP_000735556.1|728230_728737_+|hypothetical-protein
MKKLLTASIIACSVVMGVGLANTSAEAASGNSIDTVKQLIKGDQSLENVKIGESIKDVLTKYKNPMYSYNENGTEHYYEFHTKKGMLLVTTDGKKNNGKVTHISMMYNDANGPTYQAVKNYVGKAVTHTEYSKVAGNFGYIEKGKTTYQFASAPKDKNIKLYRIDLEK
>NC_017333.1|WP_001222139.1|728898_729615_+|hypothetical-protein
MRINDKILLENIEDYFNHKGLSPHLIDDIKEKVITDIKNSEKKDQDYIEYKRKSPAQIILMIQRNLFALQMNPVIFFILNFILISYLYDKQYVQFQAITGMSLFYCLVIFPMTIVVYLRVSQKNYLRSNKIEMIMGTIIAIISLLLIILQAFNITWGVIPITNFGHQFFFFIGIILVIAGIFYKRLEFSGIGLLFCQKTLDAMIHNPQSAQTFSLIIWILLVVLVIYFTIRLSSRTRL
>NC_017333.1|WP_001045424.1|729783_730572_+|alpha/beta-hydrolase
MNKVTINPQIQLTYQIEGKGDPIILLHGLDGNLAGFEDLQHQLASSYKVLTYDLRGHGKSSKSESYDLNDHVEDLKILMEKLNIHEAHILGHDLGGVVAKLFTDKYAYRVKSLTTIASKKDDLIHSFTQLLIQYQDDIAGFNKSEAYILLFSKLFRNQEKTMKWYQKQRIYSIKSEDDSAVAIRSLILHKDEPMYLKKRTCVPTLLINGEHDPLIKDKNHFKLESHFLNVTKKIFEHSGHAPHIEEPEAFLSYYLNFLKSVS
>NC_017333.1|WP_001018677.1|730823_731198_-|transcriptional-regulator
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL
>NC_017333.1|WP_021285860.1|732145_733075_-|DMT-family-transporter
MLLFYIIGVIVGMFIPIQTSVNSRLSLYTKSPFYTSFISFSVGTICLIVLNIFINPDVFSLHFFSNQTFNYTWFVGGLLGVGYLTGNLLLLPKLGATLTVIATVAGQIIMGVIIDTFGLFGATIHDFNLIKAIGVLLLIVGIITMNQINKCNILLTNQKHLIFWLLLGFTFGFFPPIQTTINSLLASHTHSPAFASLVSFTIGSITLLILTAIFNRSLKLKTSHLKFGKLKPIYFTGGILGMAFVTANIILMPHMGAALTTLIGMFGQILMGILIDHFGLFGSPKIAMTSRKTIGLLCILTGIILLRLF
>NC_017333.1|WP_000169038.1|733267_733492_-|DUF2922-domain-containing-protein
MTKTLELSFKSSLDKPVKLQLPQLNNIVTEQVARDSMNALVDLNILKSNSGAITKVHSAQIIDKTTTVLFEAKK

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Crispr_ID: NC_017333_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_3

886613-886695

Orphan

Consensus_repeat	Method
CACCCCAACTCGCATTGCTTGTAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017333_3

>merge|NC_017333|3|886613-886695|CRISPRCasFinder
CACCCCAACTCGCATTGCTTGTAGAATTTCTTTTCGAAATTTTCTGTGTTGGGGCCCCACCCCAACTCGCATTGCCTGTAGAA

>NC_017333|3|3|886613-886695|CRISPRCasFinder
CACCCCAACTCGCATTGCTTGTAGAA	TTTCTTTTCGAAATTTTCTGTGTTGGGGCCC
CACCCCAACTCGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_000279414.1\|897175_898186_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|273675
NC_017333.1\|WP_001074744.1\|898324_899515_+\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NC_017333.1\|WP_000070836.1\|894705_895335_+\|DUF4887-domain-containing-protein	unknown	unknown	gnl\|CDD\|234750
NC_017333.1\|WP_000654030.1\|896109_897123_+\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NC_017333.1\|WP_000638419.1\|875522_875759_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234
NC_017333.1\|WP_000057561.1\|883754_885194_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_017333.1\|WP_000229253.1\|876027_878013_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_017333.1\|WP_000816293.1\|893100_894003_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NC_017333.1\|WP_000538141.1\|874875_875526_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NC_017333.1\|WP_000513301.1\|882414_883254_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NC_017333.1\|WP_000369722.1\|886963_887875_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NC_017333.1\|WP_000958224.1\|881476_882409_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NC_017333.1\|WP_001049165.1\|890489_891077_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NC_017333.1\|WP_001248939.1\|887871_888867_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NC_017333.1\|WP_000006551.1\|888975_889920_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NC_017333.1\|WP_000134958.1\|885260_886196_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NC_017333.1\|WP_000749384.1\|873862_874702_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NC_017333.1\|WP_000675901.1\|891259_892894_+\|NAD-dependent-malic-enzyme	unknown	unknown	gnl\|CDD\|237414
NC_017333.1\|WP_001224800.1\|883261_883747_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NC_017333.1\|WP_000662684.1\|878020_880867_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_000279414.1\|897175_898186_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|273675	TIGR01534, Glyceraldehyde-3-phosphate_dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, type I. This model represents glyceraldehyde-3-phosphate dehydrogenase (GAPDH), the enzyme responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. Forms exist which utilize NAD (EC 1.2.1.12), NADP (EC 1.2.1.13) or either (1.2.1.59). In some species, NAD- and NADP- utilizing forms exist, generally being responsible for reactions in the anabolic and catabolic directions respectively. Two Pfam models cover the two functional domains of this protein; pfam00044 represents the N-terminal NAD(P)-binding domain and pfam02800 represents the C-terminal catalytic domain. An additional form of gap gene is found in gamma proteobacteria and is responsible for the conversion of erythrose-4-phosphate (E4P) to 4-phospho-erythronate in the biosynthesis of pyridoxine. This pathway of pyridoxine biosynthesis appears to be limited, however, to a relatively small number of bacterial species although it is prevalent among the gamma-proteobacteria. This enzyme is described by TIGR001532. These sequences generally score between trusted and noise to this GAPDH model due to the close evolutionary relationship. There exists the possiblity that some forms of GAPDH may be bifunctional and act on E4P in species which make pyridoxine and via hydroxythreonine and lack a separate E4PDH enzyme (for instance, the GAPDH from Bacillus stearothermophilus has been shown to posess a limited E4PD activity as well as a robust GAPDH activity). There are a great number of sequences in the databases which score between trusted and noise to this model, nearly all of them due to fragmentary sequences. It seems that study of this gene has been carried out in many species utilizing PCR probes which exclude the extreme ends of the consenses used to define this model. The noise level is set relative not to E4PD, but the next closest outliers, the class II GAPDH's (found in archaea, TIGR01546) and aspartate semialdehyde dehydrogenase (ASADH, TIGR01296) both of which have highest-scoring hits around -225 to the prior model. [Energy metabolism, Glycolysis/gluconeogenesis].	0
NC_017333.1\|WP_001074744.1\|898324_899515_+\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NC_017333.1\|WP_000070836.1\|894705_895335_+\|DUF4887-domain-containing-protein	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	7.04966e-05
NC_017333.1\|WP_000654030.1\|896109_897123_+\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	1.39665e-92
NC_017333.1\|WP_000638419.1\|875522_875759_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
NC_017333.1\|WP_000057561.1\|883754_885194_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	7.86204e-06
NC_017333.1\|WP_000229253.1\|876027_878013_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_017333.1\|WP_000816293.1\|893100_894003_-\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	6.98978e-153
NC_017333.1\|WP_000538141.1\|874875_875526_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NC_017333.1\|WP_000513301.1\|882414_883254_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	4.21225e-120
NC_017333.1\|WP_000369722.1\|886963_887875_+\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
NC_017333.1\|WP_000958224.1\|881476_882409_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NC_017333.1\|WP_001049165.1\|890489_891077_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NC_017333.1\|WP_001248939.1\|887871_888867_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
NC_017333.1\|WP_000006551.1\|888975_889920_+\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
NC_017333.1\|WP_000134958.1\|885260_886196_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	1.80771e-153
NC_017333.1\|WP_000749384.1\|873862_874702_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	2.50875e-42
NC_017333.1\|WP_000675901.1\|891259_892894_+\|NAD-dependent-malic-enzyme	gnl\|CDD\|237414	PRK13529, PRK13529, oxaloacetate-decarboxylating malate dehydrogenase.	0
NC_017333.1\|WP_001224800.1\|883261_883747_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.7022e-30
NC_017333.1\|WP_000662684.1\|878020_880867_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0

>NC_017333.1|WP_000134958.1|885260_886196_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIETKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NC_017333.1|WP_000057561.1|883754_885194_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMANQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVIENDLMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NC_017333.1|WP_001224800.1|883261_883747_+|acetyltransferase
MRKFLSKTYHHTNPLWHVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NC_017333.1|WP_000513301.1|882414_883254_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPGEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>NC_017333.1|WP_000958224.1|881476_882409_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NC_017333.1|WP_000662684.1|878020_880867_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNINLSEQDQAIANQILKEIISRLAFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKINRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDN
>NC_017333.1|WP_000229253.1|876027_878013_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NC_017333.1|WP_000638419.1|875522_875759_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NC_017333.1|WP_000538141.1|874875_875526_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NC_017333.1|WP_000749384.1|873862_874702_+|CHAP-domain-containing-protein
MKKSLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKTVKSPVRKASQAKKVVKQPVQQASKKVVVKQAPKQTVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>NC_017333.1|WP_000369722.1|886963_887875_+|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NC_017333.1|WP_001248939.1|887871_888867_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NC_017333.1|WP_000006551.1|888975_889920_+|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>NC_017333.1|WP_001049165.1|890489_891077_+|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NC_017333.1|WP_000675901.1|891259_892894_+|NAD-dependent-malic-enzyme
MKGIELLNNPFLNKGIAFTNEERKQLGLEGLLPANVRTLEQQAEQCYEQFKAKQTDFEKRLFLMAIFNRNRTLFYKLTSEHLVEFMPIIYDPVIAQSIEQYNENFSRPQDAVFLSVDRQDQIEQELRNVANGRDIRLIVVTDAEGILGIGDWGVDGVDIAIGKLIVYTAAAGINPSQVLPVSLDVGTNNEQLLNDDLYLGNRHKRVDDETYYAFVDKFVSAVRKEYPNALLHWEDFGRGHAKNILDKYEDTLPTFNDDIQGTGIVTLAGVLGALNISKVNYTNQTFLVYGGGTAGMGITNILKDELIKQGVSEEKANQHFYIMDKQGLLFDDMDDLTEAQQVFAKNRNEFSKTVNWKNLKEVIENIKPTVLIGTSTQTGAFTEDAVKEMLKHTERPMIFPLSNPTKLAEATAQDLLKWTNGKALIGTGIPYNDIEYNGVNYSIGQANNALMYPGLGLGLIASKAKKVNQQILSAASHALGGMVNPDEPGAAVLPPVEKIHQCSRAIAKAVAQSVIDQGLNAETIDDIDKAIEAEIWYPEYKSYI
>NC_017333.1|WP_000816293.1|893100_894003_-|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQKIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGIILSNEGGALQTMKLPYEYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLISK
>NC_017333.1|WP_000070836.1|894705_895335_+|DUF4887-domain-containing-protein
MSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERMLNEQNQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAPTKQRPAKEENDDKASKDESKDKDDKASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNNNQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK
>NC_017333.1|WP_000654030.1|896109_897123_+|sugar-binding-transcriptional-regulator
MKDLLQAQQKLIPDLIDKMYKRFSILTTISKNQPVGRRSLSEHMDMTERVLRSETDMLKKQDLIKVKPTGMEITAEGEQLISQLKGYFDIYADDNRLSEGIKNKFQIKEVHVVPGDADNSQSVKTELGRQAGQLLEGILQEDAIVAVTGGSTMACVSEAIHLLPYNVFFVPARGGLGENVVFQANTIAASMAQQAGGYYTTMYVPDNVSETTYNTLLLEPSVINTLDKIKQANVILHGIGDALKMAHRRQSPEKVIEQLQHHQAVGEAFGYYFDTQGQIVHKVKTIGLQLEDLESKDFIFAVAGGKSKGEAIKAYLTIAPKNTVLITDEAAAKIILE
>NC_017333.1|WP_000279414.1|897175_898186_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
>NC_017333.1|WP_001074744.1|898324_899515_+|phosphoglycerate-kinase
MAKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGGKIVLFSHLGKVKEESDKAKLTLRPVAEDLSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKKESKNDPDLGKYWASLGDVFVNDAFGTAHREHASNVGISTHLETAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAYTFLKAQGKEIGISLLEEDKIDFAKDLLEKHGDKIVLPVDTKVAKEFSNDAKITVVPSDSIPADQEGMDIGPNTVKLFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLKDAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEYLEGKELPGIKAINNK

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Crispr_ID: NC_017333_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_4

935963-936043

Orphan

Consensus_repeat	Method
TCTTTATCATTTCTGTCCCACTCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017333_4

>merge|NC_017333|4|935963-936043|CRISPRCasFinder
TCTTTATCATTTCTGTCCCACTCCCAAGAACCAATACATAATAAAGCATAAGTGATTCTTTATCATTTCTCTCCCACTCCC

>NC_017333|4|4|935963-936043|CRISPRCasFinder
TCTTTATCATTTCTGTCCCACTCCC	AAGAACCAATACATAATAAAGCATAAGTGAT
TCTTTATCATTTCTCTCCCACTCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_000168845.1\|937792_938554_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NC_017333.1\|WP_001018957.1\|931900_932287_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224572
NC_017333.1\|WP_000205572.1\|938652_939960_+\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NC_017333.1\|WP_001183849.1\|936613_937465_-\|DUF368-domain-containing-protein	unknown	unknown	gnl\|CDD\|224946
NC_017333.1\|WP_000571213.1\|932825_933851_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224058
NC_017333.1\|WP_001074405.1\|941920_943318_+\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NC_017333.1\|WP_000274033.1\|943649_943964_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_001147955.1\|928782_929103_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_017333.1\|WP_001010508.1\|941305_941770_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918
NC_017333.1\|WP_000732338.1\|934556_935378_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NC_017333.1\|WP_000582322.1\|944332_945373_+\|DUF21-domain-containing-protein	unknown	unknown	gnl\|CDD\|226911
NC_017333.1\|WP_000267231.1\|945386_946454_+\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|224981
NC_017333.1\|WP_001825559.1\|940065_941316_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NC_017333.1\|WP_000422911.1\|928093_928633_+\|nitroreductase	unknown	unknown	gnl\|CDD\|380312
NC_017333.1\|WP_000932205.1\|930320_931199_+\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|226395
NC_017333.1\|WP_001065802.1\|932279_932576_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_017333.1\|WP_000520237.1\|933843_934539_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NC_017333.1\|WP_000589549.1\|929246_929603_+\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239334
NC_017333.1\|WP_000290492.1\|929760_930141_+\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NC_017333.1\|WP_000752917.1\|936185_936380_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_000168845.1\|937792_938554_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	1.29081e-150
NC_017333.1\|WP_001018957.1\|931900_932287_+\|hypothetical-protein	gnl\|CDD\|224572	COG1658, COG1658, Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair].	4.21303e-36
NC_017333.1\|WP_000205572.1\|938652_939960_+\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	8.11734e-136
NC_017333.1\|WP_001183849.1\|936613_937465_-\|DUF368-domain-containing-protein	gnl\|CDD\|224946	COG2035, COG2035, Predicted membrane protein [Function unknown].	2.68358e-76
NC_017333.1\|WP_000571213.1\|932825_933851_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	2.03316e-170
NC_017333.1\|WP_001074405.1\|941920_943318_+\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NC_017333.1\|WP_001147955.1\|928782_929103_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	3.63533e-24
NC_017333.1\|WP_001010508.1\|941305_941770_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	6.42482e-68
NC_017333.1\|WP_000732338.1\|934556_935378_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	5.3847e-113
NC_017333.1\|WP_000582322.1\|944332_945373_+\|DUF21-domain-containing-protein	gnl\|CDD\|226911	COG4536, CorB, Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism].	2.87954e-160
NC_017333.1\|WP_000267231.1\|945386_946454_+\|nitronate-monooxygenase	gnl\|CDD\|224981	COG2070, COG2070, Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only].	2.6112e-111
NC_017333.1\|WP_001825559.1\|940065_941316_+\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NC_017333.1\|WP_000422911.1\|928093_928633_+\|nitroreductase	gnl\|CDD\|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	3.60721e-49
NC_017333.1\|WP_000932205.1\|930320_931199_+\|DUF1963-domain-containing-protein	gnl\|CDD\|226395	COG3878, COG3878, Uncharacterized protein conserved in bacteria [Function unknown].	1.16986e-75
NC_017333.1\|WP_001065802.1\|932279_932576_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	3.92494e-14
NC_017333.1\|WP_000520237.1\|933843_934539_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	1.61333e-99
NC_017333.1\|WP_000589549.1\|929246_929603_+\|arsenate-reductase-family-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	1.06191e-56
NC_017333.1\|WP_000290492.1\|929760_930141_+\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	1.19798e-69
NC_017333.1\|WP_000752917.1\|936185_936380_+\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	5.95583e-07

>NC_017333.1|WP_000732338.1|934556_935378_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKLFGLILVLTFAVVLAACGNGSKSGSDDKKITVGASPAPHAEILEKAKPLLEKKGYELDIKTINDYTTPNKLLDKGEIDANYFQHTPYLNTEKKDKGYKIVSAGNVHLEPMAVYSKKYKSLKELPKGATVYVSNNPAEQGRFLKFFVDAGLIKIKKGVKIEDAKFSDITENKKDIKFNNKQSAEFLPKIYQNEDADAVIINSNFAIEQKLNPKKDSIAVESAKDNPYANLIAVKEGHQDDKKIKALIEVLQSKDIQDFINEKYNGAVIPAK
>NC_017333.1|WP_000520237.1|933843_934539_+|ABC-transporter-permease
MGKSFSEIINEMITMPNIQWPEVWTAIVETLYMTVVSTIFTFILGLILGVLLFLSAKGKSIGARLFYSIVSFIVNLFRAIPFIILILLLIPFTSLILGTISGPTGALPALIIGAAPFYARLVEIAFKEIDKGVIEAAWSMGANTWTVIRKVLLPEAMPALVSGITVTAIALVGSTAVAGVIGAGGLGNLAYLTGFTRNQNDVILVSTVFILIIVFIIQFIGDWLTNKLDKR
>NC_017333.1|WP_000571213.1|932825_933851_+|methionine-ABC-transporter-ATP-binding-protein
MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIVLITHEMHVIRRICDEVAVMESGKVIEHGPVTQVFENPQHTVTKRFVKEDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSVDFGKFEKELIERQVKMEVLRHG
>NC_017333.1|WP_001065802.1|932279_932576_+|thioredoxin-family-protein
MNNSLDIKDVTTFYEEDKHLIFGYTPTCGTCKVSERMLDIANEILQLPLLKIDLNFYPQFCKDMQIMSTPILLLMNKDKEVKRIYAFQSVTDLLENLK
>NC_017333.1|WP_001018957.1|931900_932287_+|hypothetical-protein
MAIVNKVIIVEGKSDKKRVQQVIAEPVNIICTHGTMSIDKFDDMIESLYDKQVFVLADSDDEGDRIRNWFKRYLSESEHIFIDKTYCQVANCPKQYLAHVLSKHGFTCKKETPFLPNINNERLVLVNE
>NC_017333.1|WP_000932205.1|930320_931199_+|DUF1963-domain-containing-protein
MLNIQDVSHLSKKEQKAYNRFVESVENGNLPILPCIEMDLKEMQEETLNQSKIGGMPFLKSFKDIPLDENNVPMVLLAQINLDDLPEQQELFPVNEGILQFWISSEDQMYGMSENLKGNNINSRLVYIKEPISDLSLKDIQAHLKSLNADNEDIPFSGAFSIEFRLSKQTITCTDYKYDEDVLALWNKVNPSFALKSMFGGYDELMEPVCNTFTAKEPFNQLGGYPYFDQIDPRTNDQGLKMYDRVLLQIDSTRDGNSSIIWGDLGIANILVKSTDLEAMKFDDYMYSWDCS
>NC_017333.1|WP_000290492.1|929760_930141_+|glycine-cleavage-system-protein-GcvH
MAVPNELKYSKEHEWVKVEGNVATIGITEYAQSELGDIVFVELPETDDEINEGDTFGSVESVKTVSELYAPISGKVVEVNEELEDSPEFVNESPYEKAWMVKVEVSDESQLEALLSAEKYAEMIGE
>NC_017333.1|WP_000589549.1|929246_929603_+|arsenate-reductase-family-protein
MIKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTGVEINKLFNTHGAKYRELDLKNKLQTLSDDEKLELLSSDGMLVKRPLAVMGDKITLGFKEDQYKETWLA
>NC_017333.1|WP_001147955.1|928782_929103_-|thioredoxin-family-protein
MQAIKSNESFKSVINSDTPVIVKFEAGWCPDCRAMDLWIDPIVEQYNDYQWYTVNRDELEDVVVENEVMGIPSLLVFKNGDKIAHLHSANAKSPEQVESFLAETFK
>NC_017333.1|WP_000422911.1|928093_928633_+|nitroreductase
MELQQAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFAFPNELDKQQCHYDAVTKLGGMLLLILKTDPRQRQNDENYFAFGAYAQNLMLLLYEVGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYLTDLEEDMPKAPRKNRNLITLY
>NC_017333.1|WP_000752917.1|936185_936380_+|CsbD-family-protein
MADESKFEQAKGNVKETVGNVTDNKNLENEGKEDKASGKAKEFVENAKEKATDFIDKVKGNKGE
>NC_017333.1|WP_001183849.1|936613_937465_-|DUF368-domain-containing-protein
MQQFKWINILKGFAMGTSDLVPGVSGGTIALLLGIYNQFIASISGIFSRRFWPSFTFLIPIIIGMLLAMGSLSNLFNYLLSQHHIPTMFFFGGLIIGIVPYLLKISNYKTSFTTKHYMMVIAGIAILIVITLMNNGDKHAGETLTLSTGLIIKYFIAGMCASSAMLLPGISGSFMLLVFGVYGTVMLAISEFVKLNFAGLPILLAVGFGVLAGFIISSKIIQYFLTHHKLMTFALIIGFVVGSLFAVFPGLPTNIVMWFVSLVVFIIGFIVSLTLGRITAENE
>NC_017333.1|WP_000168845.1|937792_938554_+|Fe-S-cluster-assembly-ATPase-SufC
MASTLEIKDLHVSIEDKEILKGVNLTINTDEIHAIMGPNGTGKSTLSSAIMGHPSYEVTKGEVLLDGVNILELEVDERAKAGLFLAMQYPSEITGVTNADFMRSAINAKREEGQEINLMQFIKKLDKNMDFLDIDKDMAQRYLNEGFSGGEKKRNEILQLMMLEPKFAILDEIDSGLDIDALKVVSKGINQMRGENFGALMITHYQRLLNYITPDKVHVMYAGKVVKSGGPELAKRLEEEGYEWVKEEFGSAE
>NC_017333.1|WP_000205572.1|938652_939960_+|Fe-S-cluster-assembly-protein-SufD
MTTDILNISEEQLVDYSKAHNEPSWMTELRKKALKLTETLEMPKPDKTKLRKWDFDSFKQHDVKGDVYQSLSQLPESVREIIDVDHSKNLVIQHNNTIAYTQVDDNASKDGVIVEGLADALMNHSDLVQKYFMKDAVTVDEHRITALHTALVNGGVFVYVPKNVVVEHPVQYVVLHDDENASFYNHVIIVTEESAEVTYVENYLSNASGEGNQLNIISEVIAGANSNITYGSVDYMDKGFTGHIIRRGITEADASINWALGLMNEGSQIIDNTTNLFGDRSTSSLKSVVVGTGEQKINLTSKIVQYGKETDGYILKHGVMKEHASSVFNGIGYIKHGGTKSIANQESRVLMLSEHARGDANPILLIDEDDVQAGHAASVGRVDPDQLYYLMSRGISQREAERLVIHGFLDPVVRELPIEDVKRQLREVIERKVSK
>NC_017333.1|WP_001825559.1|940065_941316_+|cysteine-desulfurase
MNEVAEHSFDVNEVIKDFPILDQKVNGKRLAYLDSTATSQTPVQVLNVLEDYYKRYNSNVHRGVHTLGSLATDGYENARETVRRFINAKYFEEIIFTRGTTASINLVAHSYGDANVEEGDEIVVTEMEHHANIVPWQQLAKRKNATLKFIPMTADGELNIEDIKQTINDKTKIVAIAHISNVLGTINDVKTIAEIAHQHGAIISVDGAQAAPHMKLDMQEMNADFYSFSGHKMLGPTGIGVLFGKRELLQKMEPIEFGGDMIDFVSKYDATWADLPTKFEAGTPLIAQAIGLAEAIRYLERIGFDAIHKYEQELTIYAYEQMSTIEGIEIYGPPKDRRAGVITFNLQDVHPHDVATAVDTEGVAVRAGHHCAQPLMKWLNVSSTARASFYIYNTKEDIDQLINALKQTKEFFSYEF
>NC_017333.1|WP_001010508.1|941305_941770_+|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MNFNNLDQLYRSVIMDHYKNPRNKGVLDNGSMTVDMNNPTCGDRIRLTFDIEDGIIKDAKFEGEGCSISMASASMMTQAVKGHSLGEAMQMSQEFTKMMLGEDYVITEEMGDIEALQGVSQFPARIKCATLAWKALEKGTVAKEGKAEGTTEEE
>NC_017333.1|WP_001074405.1|941920_943318_+|Fe-S-cluster-assembly-protein-SufB
MAKKAPDVGDYKYGFHDDDVSIFRSERGLTENIVREISNMKNEPEWMLDFRLKSLKLFYKMPMPQWGGDLSELNFDDITYYVKPSEQAERSWDEVPEEIKRTFDKLGIPEAEQKYLAGVSAQYESEVVYHNMEKELEEKGIIFKDTDSALQENEELFKKYFASVVPAADNKFAALNSAVWSGGSFIYVPKNIKLDTPLQAYFRINSENMGQFERTLIIADEGASVHYVEGCTAPVYTTSSLHSAVVEIIVHKDAHVRYTTIQNWANNVYNLVTKRTFVYENGNMEWVDGNLGSKLTMKYPNCVLLGEGAKGSTLSIAFAGKGQVQDAGAKMIHKAPNTSSTIVSKSISKNGGKVIYRGIVHFGRKAKGARSNIECDTLILDNESTSDTIPYNEVFNDQISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAVEMNRLIKFEMEGSIG
>NC_017333.1|WP_000274033.1|943649_943964_-|hypothetical-protein
MYFVLAIFTIISASVSLGYSIQACASSHNINAYYALSRSLPLFLLAIFSLVIHSAIFLITISIAMILVQFLDAIVGYKSNDVFKTYGPLATSVVNLILLIVFLF
>NC_017333.1|WP_000582322.1|944332_945373_+|DUF21-domain-containing-protein
MIIAIIILIFISFFFSGSETALTAANKTKFKTEADKGDKKAKGIVKLLEKPSEFITTILIGNNVANILLPTLVTIMALRWGISVGIASAVLTVVIILISEVIPKSVAATFPDKITRLVYPIINICVIVFRPITLLLNKLTDSINRCLSKGQPQEHQFSKEEFKTMLAIAGHEGALNEIETSRLEGVINFENLKVKDVDTTPRINVTAFASNATYEEVYETVMNKPYTRYPVYEGDIDNIIGVFHSKYLLAWSNKKEDQITNYSAKPLFVNEHNKAEWVLRKMTISRKHLAIVLDEFGGTEAIVSHEDLIEELLGMEIEDEMDKKEKEKLSQQQIQFQQRKNRNVSI
>NC_017333.1|WP_000267231.1|945386_946454_+|nitronate-monooxygenase
MWNKNRLTQMLSIEFPIIQAGMAGSTTPKLVASVSNSGGLGTIGAGYFNTQQLEDEIDYVRQLTSNSFGVNVFVPSQQSYTSNQIENMNAWLKPYRRALHLEEPVVKITEEQQFKCHIDTIIKKQVPVCCFTFGIPNESIIKRLKEANIKLIGTATSVDEAIANEKAGMDAIVAQGSEAGGHRGSFLKPKNQLPMVGTISLVPQIVDVVSIPVIAAGGIMDGRGVLASIVLGAEGVQMGTAFLTSQDSNASELLRDAIINSKETDTVITKAFSGKLARGINNRFIEEMSQYEGDIPDYPIQNELTSSIRKAAANIGDKELTHMWSGQSPRLATTHPANTIMSNIINQINQIMQYK

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Crispr_ID: NC_017333_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_5

1602708-1602803

Orphan

Consensus_repeat	Method
CGTTTGTTAACTAATATTTGCATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017333_5

>merge|NC_017333|5|1602708-1602803|CRISPRCasFinder
CGTTTGTTAACTAATATTTGCATTTCTTCTCACTCCTTAATTTGTAATTCAGCGTATGAAATTATCTCATTACGCTTGTTAACTAATATTTGCATT

>NC_017333|5|5|1602708-1602803|CRISPRCasFinder
CGTTTGTTAACTAATATTTGCATT	TCTTCTCACTCCTTAATTTGTAATTCAGCGTATGAAATTATCTCATTA
CGCTTGTTAACTAATATTTGCATT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_000807542.1\|1616267_1616909_-\|tail-protein	unknown	unknown	gnl\|CDD\|273713
NC_017333.1\|WP_000110018.1\|1617339_1617741_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000916021.1\|1602183_1602348_-\|XkdX-family-protein	unknown	unknown	gnl\|CDD\|378241
NC_017333.1\|WP_001190533.1\|1608075_1608900_-\|phage-tail-family-protein	unknown	unknown	gnl\|CDD\|368574
NC_017333.1\|WP_000384460.1\|1606483_1608067_-\|phage-tail-protein	unknown	unknown	gnl\|CDD\|377677
NC_017333.1\|WP_000466774.1\|1601019_1601319_-\|DUF2951-family-protein	unknown	unknown	gnl\|CDD\|288067
NC_017333.1\|WP_000179864.1\|1606193_1606484_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|168296
NC_017333.1\|WP_001148129.1\|1599020_1600466_-\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|214760
NC_017333.1\|WP_000589167.1\|1615312_1615663_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000201920.1\|1597940_1598120_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000354117.1\|1600446_1600884_-\|phage-holin	unknown	unknown	gnl\|CDD\|130659
NC_017333.1\|WP_000378889.1\|1601521_1601914_-\|DUF2977-domain-containing-protein	unknown	unknown	gnl\|CDD\|288092
NC_017333.1\|WP_000466776.1\|1601832_1602138_-\|DUF2951-family-protein	unknown	unknown	gnl\|CDD\|288067
NC_017333.1\|WP_000169130.1\|1615720_1616176_-\|Ig-domain-containing-protein	unknown	unknown	gnl\|CDD\|227779
NC_017333.1\|WP_000438833.1\|1615112_1615271_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000126130.1\|1596573_1596789_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000429556.1\|1604267_1606178_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000916022.1\|1601364_1601529_-\|XkdX-family-protein	unknown	unknown	gnl\|CDD\|378241
NC_017333.1\|WP_001023808.1\|1616943_1617339_-\|DUF3168-domain-containing-protein	unknown	unknown	unknown
NC_017333.1\|WP_043854724.1\|1597004_1597421_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_000807542.1\|1616267_1616909_-\|tail-protein	gnl\|CDD\|273713	TIGR01603, Uncharacterized_phage_related_protein, phage major tail protein, phi13 family. This model describes a set of proteins that share low levels of sequence similarity but similar lengths and similar patterns of charged, hydrophobic, and Gly/Pro residues. All members (except one attributed to mouse embryo cDNA) belong to phage of Gram-positive bacteria. Several are identified as phage major tail proteins. Some members of this family have additional C-terminal regions of about 100 residues not included in this model. [Mobile and extrachromosomal element functions, Prophage functions].	1.67525e-11
NC_017333.1\|WP_001148129.1\|1599020_1600466_-\|SH3-domain-containing-protein	gnl\|CDD\|214760	smart00644, Ami_2, Ami_2 domain.	4.81401e-23
NC_017333.1\|WP_000384460.1\|1606483_1608067_-\|phage-tail-protein	gnl\|CDD\|377677	pfam06605, Prophage_tail, Prophage endopeptidase tail. This family is of prophage tail proteins that are probably acting as endopeptidases.	6.05546e-22
NC_017333.1\|WP_001190533.1\|1608075_1608900_-\|phage-tail-family-protein	gnl\|CDD\|368574	pfam05709, Sipho_tail, Phage tail protein. This family consists of several Siphovirus and other phage tail component proteins as well as some bacterial proteins of unknown function.	2.67026e-44
NC_017333.1\|WP_000466774.1\|1601019_1601319_-\|DUF2951-family-protein	gnl\|CDD\|288067	pfam11166, DUF2951, Protein of unknown function (DUF2951). This family of proteins has no known function. It has a highly conserved sequence.	1.72639e-46
NC_017333.1\|WP_000179864.1\|1606193_1606484_-\|hypothetical-protein	gnl\|CDD\|168296	PRK05926, PRK05926, hypothetical protein; Provisional.	0.00037324
NC_017333.1\|WP_000169130.1\|1615720_1616176_-\|Ig-domain-containing-protein	gnl\|CDD\|227779	COG5492, COG5492, Bacterial surface proteins containing Ig-like domains [Cell motility and secretion].	5.37204e-09
NC_017333.1\|WP_000354117.1\|1600446_1600884_-\|phage-holin	gnl\|CDD\|130659	TIGR01598, holin_phiLC3, holin, phage phi LC3 family. Phage proteins for bacterial lysis typically include a membrane-disrupting protein, or holin, and one or more cell wall degrading enzymes that reach the cell wall because of holin action. Holins are found in a large number of mutually non-homologous families. [Mobile and extrachromosomal element functions, Prophage functions].	1.37709e-34
NC_017333.1\|WP_000378889.1\|1601521_1601914_-\|DUF2977-domain-containing-protein	gnl\|CDD\|288092	pfam11192, DUF2977, Protein of unknown function (DUF2977). This family of proteins has no known function.	2.73079e-12
NC_017333.1\|WP_000916021.1\|1602183_1602348_-\|XkdX-family-protein	gnl\|CDD\|378241	pfam09693, Phage_XkdX, Phage uncharacterized protein (Phage_XkdX). This entry identifies a family of small (about 50 amino acid) phage proteins, found in at least 12 different phage and prophage regions of Gram-positive bacteria. In a number of these phage, the gene for this protein is found near the holin and endolysin genes.	2.03397e-10
NC_017333.1\|WP_000916022.1\|1601364_1601529_-\|XkdX-family-protein	gnl\|CDD\|378241	pfam09693, Phage_XkdX, Phage uncharacterized protein (Phage_XkdX). This entry identifies a family of small (about 50 amino acid) phage proteins, found in at least 12 different phage and prophage regions of Gram-positive bacteria. In a number of these phage, the gene for this protein is found near the holin and endolysin genes.	7.4734e-11
NC_017333.1\|WP_000466776.1\|1601832_1602138_-\|DUF2951-family-protein	gnl\|CDD\|288067	pfam11166, DUF2951, Protein of unknown function (DUF2951). This family of proteins has no known function. It has a highly conserved sequence.	1.28854e-43

>NC_017333.1|WP_000916021.1|1602183_1602348_-|XkdX-family-protein
MLKLISPTFEDIKTWYQLKEYTKEDIAWYVDMEVIDKEEYAIITGEKYPENIES
>NC_017333.1|WP_000466776.1|1601832_1602138_-|DUF2951-family-protein
MFGFTKRHEQDWRLTRLEENDKTMFEKFDRIEDSLRAQEKIYDKLDRNFEELKRDKEEDEKNKEKNAKNIRDIKMWILGLIGTILSTFVIALLVVLKKVLI
>NC_017333.1|WP_000378889.1|1601521_1601914_-|DUF2977-domain-containing-protein
MDSWINRDDTKYVCYSVIGGFEEGIDIESLPENFSQVFRPKVFKYSDGKIIFNEDYTEEKDDSHQQIDNEENSTGASDDILRKMVASMQKQVVQSTKLLMQVNKQNALMAKQIVAFNKKLEEIKGETENA
>NC_017333.1|WP_000916022.1|1601364_1601529_-|XkdX-family-protein
MLKLISPTFEDIKTWYQLKEYTKEDIAWYVDMEVIDKEEYAIITGEKYPENLVS
>NC_017333.1|WP_000466774.1|1601019_1601319_-|DUF2951-family-protein
MFGFTKRHEQDWRLTRLEENDKTMFEKFDRIEDSLRAQEKIYDKLDRNFEELKRDKEEDEKNKEKNAKNIRDIKMWILGLIGTILSTFVIAILKTVFGI
>NC_017333.1|WP_000354117.1|1600446_1600884_-|phage-holin
MDINWKLRFKNKAVLTGLIGALLLFIKQITDLFGFDLSNQLNQASAIIGAILTLLTGIGVITDPTSKGVADSSIAQTYQAPRDSSKEEQQVTWKTSQDASLTPELSTKAPKEYDTSQPFTDASNDVGFDVNEYHYGGGDNASKID
>NC_017333.1|WP_001148129.1|1599020_1600466_-|SH3-domain-containing-protein
MQAKLTKKEFIEWLKTSEGKQFNIDLWYGFQCFDYANAGWQVLFGYNLKGVGAKDIPSANNFNGLATVYQNTPDFLAQPGDMVVFGSNYGAGYGHVAWVIEATLDYIIVYEQNWLGGGWTDGIEQPGWGWEKVTRRQHAYDFPMWFIRPNFKSEISPRSVQSPTQAPKKETAKPQPKAVELKIIKDVVKGYDLPKRGGNPKGIVIHNDAGSKGATAEAYRNGLVNAPLSRLEAGIAHSYVSGNTVWQALDESQVGWHTANQVGNKYYYGIEVCQSMGADNATFLKNEQATFQECARLLKKWGLPANRNTIRLHNEFISTSCPHRSSVLHTGFDPITRGLLPEDKRLQLKDYFIKQIRAYMDGKIPVATVSNESSASSNTVKPVASAWKRNKYGTYYMEESARFTNGNQPITVRKVGPFLSCPVGYQFQPGGYCDYTEVMLQNGHVWVGYNWEGQRYYLPIRTWNGSAPPNQILGDLWGEIS
>NC_017333.1|WP_000201920.1|1597940_1598120_-|hypothetical-protein
MATKSFTTDYKFNNKAAEKLVNAMNKSEDAQFNRSNVFAQRLKTMEDLQNFKNKVKVIL
>NC_017333.1|WP_043854724.1|1597004_1597421_-|hypothetical-protein
MRRNLLVHTRSPHDYIGKIVKIRLPYYDVKSAKVAFKSRPGLIIGCEKNQFPCDFTYLPISKISDESKRHSIYDFEVNDETCNLLNLNNVPSFVRCHKVSTVYSKNVHRNYISDLNETNNRLFNEIKSIFDAFATDLF
>NC_017333.1|WP_000126130.1|1596573_1596789_-|hypothetical-protein
MTALPSHYDDMFILNTQAHARLDQMAQQFEVVCNGLNENEGQAIQTMDQSASLIRSNLIQVKEQLEKLAVY
>NC_017333.1|WP_000429556.1|1604267_1606178_-|hypothetical-protein
MENLYLIKDLGALAGRDYRAKEIQNLQRIEQFALGLTTEFKLHQKAKTIQHFAEQIYYNGRSQASVNKSLQSQINSLVLAPRNNSANEIVQARVNVNGETFDTLKEHLDDWETKTQINKEETIRELNKAKQQILDIEYRFEPDKQEFLFVTELAPLTNAVMQSFWFDNRTGIVYMTQARNNGYMLSRLRPNGQFIDSSLIVGGGHGTHNGYRYIDDELWIYSFILNGNNENTLVRFKYTPNVEISYGKYGMQDVFTGHPEKPYITPVINEKENKILYRIERPRSQWELENSMNYIEIRSLDDVDKNIDKVLHKISIPMRLTNETQPMQGVTFDEKYLYWYTGDSNPNNRNYLTAFDLETGEEAYQVNADYGGTLDSFPGEFAEAEGLQIYYDKDSGKKALMLGVTVGGDGNRTHRIFMIGQRGILEILHSRGVPFIMSDTGGRVKPLPMRPDKLKNLGMLTEPGLYYLYTDHTVQIDDFPLPREWRDAGWFLEVKPPQTGGDVIQILTRNSYARNMMTFERVLSGRTGDISDWNYVPKNSGKWERVPSFITKMSDINIVGMSFYLTTDDTKRFTDFPTERKGVAGWNLYVEASNTGGFVHRLVRNSVTASAEILLKNYDSKTSSGPWTLHEGRIIS
>NC_017333.1|WP_000179864.1|1606193_1606484_-|hypothetical-protein
MATEEVKIKALLENDKQYFPATHWKAINGVPYAGSSDIDGLPQDGIISVDDKNKLDNLKIGEAGIIQNSIVQKSPNGKLWKITVDDSGKLGTVLFY
>NC_017333.1|WP_000384460.1|1606483_1608067_-|phage-tail-protein
MDYHDHLSVMDFNELICENLLDVDYGSFKEYYELNEARYITFTVYRTTHNSFVFDLLICENFIIYHGEKYTIKQTAPKVEGDKVFIEVTAYHIMYEFQNHSVESNKLDDDSSETGKTPEYSLDEYLRYGFANQKTSVKMTYKIIGDFKRKIPIDELGNKNGLEYCKEAVDLFGCIIYPNDTEICFYSPETFYQRSEKVIRYQYNTDTVSATVSTLELRTAIKVFGKKYTAEEKKNYNPIKTTDINYSNDFIKEGTYRTETIGSKATINFDCKYGNETVRFTIKKGSQGGIYKLILDGKQIKQISCFAKSVQSETIDLIKNIDKGKHVLEMIFLGEDPKNRIDISSNKKAKPCMYVGTEKSTVLNLIADNSGRNQYKAIVDYVADSAKQFGIRYANTQTNEDIETQDKLLEFAKKQINDTPKTELDVNYIGYEKIEPRDSVFFVHELMGYNTELKVVKLDRSHPFVNAIDEVSFSNEIKDMVQIQQALNRRVIAQDNRYNYQANRINHLYTSTLNSPFETMDIGSVLI
>NC_017333.1|WP_001190533.1|1608075_1608900_-|phage-tail-family-protein
MQSFVKIIDGYKEEVITDFNQLIFLDARAESPNTNDNSVTINGVDGILPGAISFAPFSLVLRFGYDGIDVIDLNLFEHWFRSVFNRRHPYYVITSQMPGVKYAVNTANVTSNLKDGSSTEIEVSLNVYKGYSESVNWTDSEFLFDSNWMFENGIPLDFTPKYTHTSNQFTIWNGSTDTINPRFKHDLKILINLNASGGFELVNYTTGDIFKYNKSIDKNTDFVLDGVYAYRDINRVGIDTNRGIITLAPGKNEFKIKGDVSDIKTTFKFPFIYR
>NC_017333.1|WP_000438833.1|1615112_1615271_-|hypothetical-protein
MEQYGWTLTEVRKQPYVKLLEILNEENKEETEEKQSEQKVITGTDLRKLFGS
>NC_017333.1|WP_000589167.1|1615312_1615663_-|hypothetical-protein
MIKFEIKDRKTGKTESYTKEDVTMGEAEKCYEYLELVNQENKKEAPNATKMRQKERQLLVDLFKDEGLTEEDVLNKMSTKTYTKALQDIFREINGEDEEDSETEPEEMGKTEEQSQ
>NC_017333.1|WP_000169130.1|1615720_1616176_-|Ig-domain-containing-protein
MTKTLKVYKGDDVVASEQGEGKVSVTLSNLEADTTYPKGTYQVAWEENGKESSKVDVPQFKTNPILVSGVSFTPETKSIMVNTDDNVEPNIAPSTATNKTLKYTSEHPEFVTVDERTGAIHGVAEGTSVITATSTDGSDKSGQITVTVTNG
>NC_017333.1|WP_000807542.1|1616267_1616909_-|tail-protein
MAEGQGSYKVGFKRLYVGVFNPEATKVVKRMTWEDEKGGTVDLNITGLAPDLVDMFASNKRVWMKKQGTNEVKSDMSIFNIPSEDLNTVIGRTKDKNGTSWVGENTRAPYVTVIGESEDGLTGQPVYVALLKGTFSLDSIEFKTRGEKAEAPEPTKLTGDWMNRKVDVDGTPQGIVYGYHEGKEGEAEFFKKVFVGYTDSEDHSEDSAGSLPS
>NC_017333.1|WP_001023808.1|1616943_1617339_-|DUF3168-domain-containing-protein
MNILNTVKGILLSDAELKTHINSRIYYYKVTENAETSKPFVVITPVYDLPSDFMSDKYLSEEYLIQIDVESSNHQKTIDITKRIRYLLYQQNLIQASSQLDAYFEETKRYVMSRRYQGIPKNIYYKNQRIE
>NC_017333.1|WP_000110018.1|1617339_1617741_-|hypothetical-protein
MSVEIKGIPEVLKKLESVYGKQAMQAKSDRALNEASEFFIKALKKEFESFKDTGASIEEMTKSKPYTKVGSQERAVLIEWVGPMNRKNIIHLNEHGYTRDGKKYTPRGFGVIAKTLAASERKYREIIKKGLAR

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Crispr_ID: NC_017333_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_6

1854733-1854815

Orphan

Consensus_repeat	Method
GAAGCTGACGAAAAAGTCAGCTTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017333_6

>merge|NC_017333|6|1854733-1854815|CRISPRCasFinder
GAAGCTGACGAAAAAGTCAGCTTACTATAATGTGCAAGTTGGGGTGGGCCCCAACACAGAAGCTGACGAAAAAGTCAGCTTAC

>NC_017333|6|6|1854733-1854815|CRISPRCasFinder
GAAGCTGACGAAAAAGTCAGCTTAC	TATAATGTGCAAGTTGGGGTGGGCCCCAACACA
GAAGCTGACGAAAAAGTCAGCTTAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_000161656.1\|1855776_1856832_+\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|223085
NC_017333.1\|WP_000690004.1\|1857147_1858266_-\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NC_017333.1\|WP_000717561.1\|1843050_1844019_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NC_017333.1\|WP_000160430.1\|1852490_1853789_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226594
NC_017333.1\|WP_000365308.1\|1862106_1862877_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NC_017333.1\|WP_000840583.1\|1860444_1861392_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|223897
NC_017333.1\|WP_000471571.1\|1845231_1846089_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
NC_017333.1\|WP_000040067.1\|1859154_1860357_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NC_017333.1\|WP_000226933.1\|1847961_1851159_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|223660
NC_017333.1\|WP_000872673.1\|1862920_1864144_-\|tRNA-4-thiouridine(8)-synthase-ThiI	unknown	unknown	gnl\|CDD\|234960
NC_017333.1\|WP_000626092.1\|1851179_1852121_-\|pApA-hydrolase-Pde2	unknown	unknown	gnl\|CDD\|223691
NC_017333.1\|WP_000818532.1\|1839566_1840928_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NC_017333.1\|WP_072434776.1\|1864143_1865292_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_017333.1\|WP_000883646.1\|1844287_1845232_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
NC_017333.1\|WP_000136251.1\|1861514_1862009_-\|thiol-peroxidase	unknown	unknown	gnl\|CDD\|179055
NC_017333.1\|WP_001232654.1\|1841271_1843029_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235784
NC_017333.1\|WP_000058389.1\|1846283_1847513_-\|NAD-dependent-malic-enzyme-4	unknown	unknown	gnl\|CDD\|235976
NC_017333.1\|WP_000777188.1\|1854912_1855602_-\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|234811
NC_017333.1\|WP_000277602.1\|1853993_1854407_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_017333.1\|WP_000634174.1\|1858406_1858925_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_000161656.1\|1855776_1856832_+\|aminopeptidase-P-family-protein	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	1.16164e-126
NC_017333.1\|WP_000690004.1\|1857147_1858266_-\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NC_017333.1\|WP_000717561.1\|1843050_1844019_-\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	0
NC_017333.1\|WP_000160430.1\|1852490_1853789_-\|CBS-domain-containing-protein	gnl\|CDD\|226594	COG4109, COG4109, Predicted transcriptional regulator containing CBS domains [Transcription].	0
NC_017333.1\|WP_000365308.1\|1862106_1862877_-\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.0657e-38
NC_017333.1\|WP_000840583.1\|1860444_1861392_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|223897	COG0827, COG0827, Adenine-specific DNA methylase [DNA replication, recombination, and repair].	6.63876e-57
NC_017333.1\|WP_000471571.1\|1845231_1846089_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	0
NC_017333.1\|WP_000040067.1\|1859154_1860357_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NC_017333.1\|WP_000226933.1\|1847961_1851159_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|223660	COG0587, DnaE, DNA polymerase III, alpha subunit [DNA replication, recombination, and repair].	0
NC_017333.1\|WP_000872673.1\|1862920_1864144_-\|tRNA-4-thiouridine(8)-synthase-ThiI	gnl\|CDD\|234960	PRK01565, PRK01565, thiamine biosynthesis protein ThiI; Provisional.	0
NC_017333.1\|WP_000626092.1\|1851179_1852121_-\|pApA-hydrolase-Pde2	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	5.72376e-100
NC_017333.1\|WP_000818532.1\|1839566_1840928_+\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NC_017333.1\|WP_072434776.1\|1864143_1865292_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	1.21752e-165
NC_017333.1\|WP_000883646.1\|1844287_1845232_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
NC_017333.1\|WP_000136251.1\|1861514_1862009_-\|thiol-peroxidase	gnl\|CDD\|179055	PRK00522, tpx, thiol peroxidase.	7.99696e-100
NC_017333.1\|WP_001232654.1\|1841271_1843029_-\|pyruvate-kinase	gnl\|CDD\|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0
NC_017333.1\|WP_000058389.1\|1846283_1847513_-\|NAD-dependent-malic-enzyme-4	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
NC_017333.1\|WP_000777188.1\|1854912_1855602_-\|metal-dependent-hydrolase	gnl\|CDD\|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	3.09103e-133
NC_017333.1\|WP_000277602.1\|1853993_1854407_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.00154e-19
NC_017333.1\|WP_000634174.1\|1858406_1858925_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	3.25322e-35

>NC_017333.1|WP_000277602.1|1853993_1854407_+|universal-stress-protein
MYKNILLGVDTQLKNEKALKEVSKLAGEGTVVTVLNAISEQDAQASIKAGVHLNKLTEERSKRLEKTRKALEDYGIDYDQIIVRGNAKEELLKHANSGKYEIVVLSNRKAEDKKKFVLGSVSHKVAKRATIPVLIVK
>NC_017333.1|WP_000160430.1|1852490_1853789_-|CBS-domain-containing-protein
MTKHEQILDYIESLSIGSKISVRKIAKFLNVSEGTAYRAIKDADKMGMVATIDRVGTVRIEKRNRNEIEHLTFNEIVNIIDGQVLGGNKGITKMVSKFAIGAMELKDILKYIGPKTLLIVGNREDVQIEALKRGTAILITGGFKPSNKVIDFANEHDLPVLSSSYDTFLVANIINKALFNQKIRKDILIVQDIMTPLDDLSVLFDTMKIADYKRMANQTGHTRFPVVNESYKLVGIVTSREMINTKDDDEIDKVMTRNPIYVNAMSTVASCAHMMIWEGIELIPVVSSNKKTVGVINRQDVLKSMQLLGRQPQMGETINDQIAKYITMNQDGITVEVSPLLINHYGTVSKAAFVSIIEETIQYEMRKFKKGNVMIENLNIVYIKTVPIESHITVRFGILDVGRNFAKIEVNMHSQNDKVASALVICQMFDEV
>NC_017333.1|WP_000626092.1|1851179_1852121_-|pApA-hydrolase-Pde2
MISTMNEIMKCIEDNDTIIIHRHVRPDPDAYGSQLGLKYYIQQKFPQKQVFAVGEAESSLSFIGELDNIDDKTYQDALVIVCDTANAPRIDDERYSTGRKLIKIDHHPAVDQYGDINLVNTNASSTSEIIYDLISHFNDEAIVNKDIASVLYLGIVGDTGRFLFNNTSEHTMEIAGKLIGHDIDHNALLNKMMEKDPKMLPFQGYVLQHFELMDDGFCQVKITEDVLKQFGIQPNEASQFVNTIADIKGLKIWVFAVDEGSEIRCRLRSKGQLIINDIAQDFGGGGHPNASGVSVNSWDEFEQLAKALRTKLN
>NC_017333.1|WP_000226933.1|1847961_1851159_-|DNA-polymerase-III-subunit-alpha
MVAYLNIHTAYDLLNSSLKIEDAVRLAVSENVDALAITDTNVLYGFPKFYDTCIANNIKPIFGMTIYVTNGLNTVETVVLAKDNNGLKDLYQLSSEIKMNALEHVSFELLKRFSNNMIIIFKNVADEHRDIVQVFDSHEDTYLDHRSVLVQGIKHVWIQDVCYQTRHDADTISALAAIRDNTKLDLIHDQEDFGAHFLTENEIQQLDVNPEYFTQADRIAQKCDAELKYHQSLLPQYQAPNDESAKKYLWRVLVTQLKKLELNYDVYLERLKYEYKVITNMGFEDYFLIVSDLIHYAKTNDVMVGPGRGSSAGSLVSYLLGITTIDPIKFNLLFERFLNPERVTMPDIDIDFEDTRREKVIQYVQEKYGELHVSGIVTFGHLLARAVARDVGRIMGFDEVTLNEISSLIPHKLGITLDEAYQIDDFKKFVHRNHRHERWFSICKKLEGLPRHTSTHAAGIIINDHPLYEYAPLTKGDTGLLTQWTMTEAERIGLLKIDFLGLRNLSIIHQILTQVKKDLGINIDIEKIPFDDQKVFELLSQGDTTGIFQLESDGVRSVLKKLKPEHFEDIVAVTSLYRPGPMEEIPTYITRRHDPSKVQYLHPHLEPILKNTYGVIIYQEQIMQIASTFANFSYGEADILRRAMSKKNRAVLESERQHFIEGAKQNGYHEDISKQIFDLILKFADYGFPRAHAVSYSKIAYIMSFLKVHYPNYFYANILSNVIGSEKKTAQMIEEAKKQGITILPPNINESHWFYKPSQEGIYLSIGTIKGVGYQSVKVIVEERYQNGKFKDFFDFARRIPKRVKTRKLLEALILVGAFDAFGKTRSTLLQAIDQVLDGDLNIEQDGFLFDILTPKQMYEDKEELPDALISQYEKEYLGFYVSQHPVDKKFVAKQYLTIFKLSNAQNNKPILVQFDKVKQIRTKNGQNMAFVTLNDGIETLDGVIFPNQFKKYEELLSHNDLFIVSGKFDLRKQQRQLIINEIQTLATFEEQKLAFAKQIIIRNKSQIDMFEEMIKATKENANDVVLSFYDETIKQMTTLGYINQKDSMFNNFIQSFNPSDIRLI
>NC_017333.1|WP_000058389.1|1846283_1847513_-|NAD-dependent-malic-enzyme-4
MSLRDEALEMHKRNQGKLEVKPNVKVTNKEELSLAYSPGVAEPCKDIYEDKRKVYDYTIKGNTVAVITDGTAVLGLGNIGPEASIPVMEGKAVLFKSFAGINGVPIALNTTDTEEIIKTVKLLEPNYGGINLEDISAPRCFEIEERLKKETNIPVFHDDQHGTAIVTMAGLVNALRVVNKDIAKIKVVLNGAGAAGIAIVKLLYAYGVRNMVMCDSRGAIFEGRSYGMNPTKDVVAKWTNKDKIEGSLEEVVKDADVFIGVSVANALSQDMVKSMADNPIIFAMANPNPEIIPDDAKAAGARVVGTGRSDYPNQINNVLAFPGIFRGALEVEATHINEEMKKAAVEAIADLIDSSELNEDYCIPGPFDKRVAPSVARNVAKAAMESGVARIEVDPQDVYDKTMKLTDLQ
>NC_017333.1|WP_000471571.1|1845231_1846089_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MFKDFFNRTKKKKYLTVQDSKNNDVPAGIMTKCPKCKKIMYTKELAENLNVCFNCDHHIALTAYKRIEAISDEGSFTEFDKGMTSANPLDFPSYLEKIEKDQQKTGLKEAVVTGTAQLDGMKFGVAVMDSRFRMGSMGSVIGEKICRIIDYCTENRLPFILFSASGGARMQEGIISLMQMGKTSVSLKRHSDAGLLYISYLTHPTTGGVSASFASVGDINLSEPKALIGFAGRRVIEQTINEKLPDDFQTAEFLLEHGQLDKVVHRNDMRQTLSEILKIHQEVTK
>NC_017333.1|WP_000883646.1|1844287_1845232_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDIEQQALAIKSAFVEQLDSLESLSRDEIANDRFEKFRNIGSYIE
>NC_017333.1|WP_000717561.1|1843050_1844019_-|6-phosphofructokinase
MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
>NC_017333.1|WP_001232654.1|1841271_1843029_-|pyruvate-kinase
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIEEILEVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVTNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQGIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
>NC_017333.1|WP_000818532.1|1839566_1840928_+|amino-acid-permease
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTYIGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGLIVVGFVMILFAYKTQFGHASFTNLYEHGVFPKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRILIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFSKTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKKATYKLFGGKYMGYLIFVFFIFVFGLLFINVETRRAIYFIPIWFILLGFMYLRYKRIAAKSNN
>NC_017333.1|WP_000777188.1|1854912_1855602_-|metal-dependent-hydrolase
MKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF
>NC_017333.1|WP_000161656.1|1855776_1856832_+|aminopeptidase-P-family-protein
MTKISKIIDELNNQQADAAWITTPLNVYYFTGYRSEPHERLFALLIKKDGKQVLFCPKMEVEEVKASPFTGEIVGYLDTENPFSLYPQTINKLLIESEHLTVARQKQLISGFNVNSFGDVDLTIKQLRNIKSEDEINKIRKAAELADKCIEIGVSYLKEGVTEREVVNHIEQTIKQYGVNEMSFDTMVLFGDHAASPHGTPGDRRLKSNEYVLFDLGVIYEHYCSDMTRTIKFGEPSQEAQEIYNIVLEAETSAIQAIKPGIPLKDIDHIARNIISEKGYGEYFPHRLGHGLGLQEHEYQDVSSTNSNLLEAGMVITIEPGIYVPGVAGVRIEDDILVTNEGYEVLTHYEK
>NC_017333.1|WP_000690004.1|1857147_1858266_-|alanine-dehydrogenase
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDNPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
>NC_017333.1|WP_000634174.1|1858406_1858925_+|universal-stress-protein
MITYKNILIAVDGSHEAEWAFNRAVGVAKRNDAKLTIVNVIDSRTYSSYEVYDAQFTEKSKHFAEELLNGYKEVATNAGVKDVETRLEFGSPKSIIPKKLAHEINADLIMSGTSGLNAVERFIVGSVSESIVRHAPCDVLVVRTEELPADFQPQVATTQLREKISKLNIDDH
>NC_017333.1|WP_000040067.1|1859154_1860357_-|acetate-kinase
MSKLILAINAGSSSLKFQLIRMPEEELVTKGLVERIGLKDSIFTIEVDGEKVKTVQDIKDHVEAVDIMLDAFKKHNIINDINDIDGTGHRVVHGGEKFPESAAITDEVEKEIEELSELAPLHNPANLMGIRAFRKLLPNIPHVAIFDTAFHQTMPEKAYLYSLPYHYYKDYGIRKYGFHGTSHKFVSQRAAEMLDKPIEDLRIISCHIGNGASIAAIDGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPFIMEKTGKTAEQVLEILNKESGLLGLSGTSSDLRDLSEEAESGKARSQMALDVFASKIHKYIGSYAARMHGVDVIVFTAGIGENSVEIRAKVLEGLEFMGVYWDPKKNENLQRGKEGFINYPHSPVKVVVIPTDEESMIARDVMTYGGLK
>NC_017333.1|WP_000840583.1|1860444_1861392_-|class-I-SAM-dependent-methyltransferase
MAEQQTIMERLFHTLDEKAKTLNNENGQSFIENLGLAMEQVYTNERGLLEQSTLQDRRKAFQFAYLSLMQEEKIQANHQITPDSIGLILGFLVERFMNNQEELHIVDIASGAGHLSATVKEVLPEIAVMHHLIEVDPVLSRVSVHLANFLEIPFDVYPQDAIMPLPLEEADIVIGDFPVGYYPIDERSRDFKLGFEEGHSYSHYLLIEQAINALKDAGYAFLVVPSNIFTGEHVKQLEKYIATETEMQAFLNLPPTLFKNEKARKSILILQKKKSGETKPVEVLLANIPDFKNPSQFQGFMTELNQWMDTNRPKK
>NC_017333.1|WP_000136251.1|1861514_1862009_-|thiol-peroxidase
MTEITFKGGPIHLKGQLINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSEASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI
>NC_017333.1|WP_000365308.1|1862106_1862877_-|TSUP-family-transporter
MDLNLTMIIIIILFGFIAAFIDSVVGGGGLISTPALLAIGLPPSVALGTNKLASSFGSLTSAIKFIRSGKVDLYVVAKLFGFVFLASACGAYIATMVPSQILKPLIIIALSSVFIFTLLKKDWGNTRTFTQFTFKKAILFAALFILIGFYDGFVGGGTGSFMLFVLLIFGFDFLSAAGNAKVLNFASNIGALVLFMVLGQVDYVIGLVMAASMIVGSYAGAHFAIKQGVGYVKVLFIIITAILILKNAFDYIQQFV
>NC_017333.1|WP_000872673.1|1862920_1864144_-|tRNA-4-thiouridine(8)-synthase-ThiI
MKYDHLLVRYGELTLKGSNRKKFVNQLRNNVNKSLKGLDGFVVKGKRDRMYIELEDHADINEITYRLSKIFGIKSISPVLKVEKTLEAMSATAIKFAQQFEENSTFKIDVKRADKNYPMDTYELQRELGGAVLKHFDNISVNVKRPDHEIRVEVRLDAIYMYEEVVQGAGGLPVGTGGKTLLMLSGGIDSPVAGMEVMRRGVTIEAIHFHSPPFTSDQAKEKVIELTRILAERVGPIKLHIVPFTELQKQVNKVVHPRYTMTSTRRMMMRVADKLVHQIGAYAIVNGENLGQVASQTLHSMYAINNVTSTPVLRPLLTYDKEEIIIKSKEIGTFETSIQPFEDCCTIFTPKNPVTEPNFDKVVQYESVFDFEEMINRAVENIETLEITSDYKTIKEQQTNQLINDFL
>NC_017333.1|WP_072434776.1|1864143_1865292_-|cysteine-desulfurase
MFILIYLDNAATTKAFEEVLDTYLKVNQSMYYNPNSPHKAGLQADQLLQQAKVQINDMVNTNMTYDVVFTSGATESNNIALKGVAYRKFDTAREIITSVLEHPSVLEVVRYLEEREGFKVKYVDVTKDGSINLEHFKELMSDKVGLVTCMYVNNVTGQIQPIPQMADVIKNYPKAHFHVDAVQAFGKISMDFNNVDSISLSGHKFNGLKGQGVLLVNHIQNVEPTVHGGGQEYGVRSGTVNLPNDIAMVKAMKIANENLEALNAFVTELNNDVRQFLNKYHGVYINSSTSGSPFVLNVSFPGVKGEVLVNAFSKYDIMISTTSACSSKRNKLNEVLTAMGLSDKAIEGSIRLSFGAMTTKEDITKFKETFTIIYEEIKELLK

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Crispr_ID: NC_017333_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_7

1942937-1943030

Orphan

Consensus_repeat	Method
GCAATGCGCGTTGGGGTGTGGGGCCCCAACATAG	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_017333_7

>merge|NC_017333|7|1942937-1943030|CRISPRCasFinder
GCAATGCGCGTTGGGGTGTGGGGCCCCAACATAGAGAATTTCAAAAAAGAAATTCTACAGGCAATGCGCGTTGGGGTGTGGGGCCTCAACATAG

>NC_017333|7|7|1942937-1943030|CRISPRCasFinder
GCAATGCGCGTTGGGGTGTGGGGCCCCAACATAG	AGAATTTCAAAAAAGAAATTCTACAG
GCAATGCGCGTTGGGGTGTGGGGCCTCAACATAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_001168915.1\|1941207_1941843_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_017333.1\|WP_000492903.1\|1942009_1942630_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_017333.1\|WP_001032832.1\|1937900_1938755_-\|glucosaminidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|226656
NC_017333.1\|WP_000366160.1\|1946731_1947640_-\|NERD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377990
NC_017333.1\|WP_000091443.1\|1944164_1944467_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_001261672.1\|1934054_1935557_-\|FAD/NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|226906
NC_017333.1\|WP_001200546.1\|1944721_1945087_+\|fluoride-efflux-transporter-CrcB	unknown	unknown	gnl\|CDD\|184566
NC_017333.1\|WP_000671058.1\|1939453_1939924_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NC_017333.1\|WP_000384171.1\|1939030_1939255_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000989103.1\|1936521_1937814_+\|arsenite-efflux-transporter-membrane-subunit-ArsB	unknown	unknown	gnl\|CDD\|185342
NC_017333.1\|WP_000109913.1\|1949329_1950922_+\|phosphoenolpyruvate-carboxykinase-(ATP)	unknown	unknown	gnl\|CDD\|238270
NC_017333.1\|WP_001096494.1\|1943192_1943906_-\|transaldolase	unknown	unknown	gnl\|CDD\|183481
NC_017333.1\|WP_001153741.1\|1940036_1940480_+\|competence-protein-ComK	unknown	unknown	gnl\|CDD\|368849
NC_017333.1\|WP_000933822.1\|1947764_1948958_-\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NC_017333.1\|WP_000672013.1\|1951969_1952443_-\|nucleoside-triphosphatase-YtkD	unknown	unknown	gnl\|CDD\|131752
NC_017333.1\|WP_001030474.1\|1940466_1940910_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000623484.1\|1945083_1945437_+\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|223317
NC_017333.1\|WP_000453302.1\|1945686_1946520_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|223729
NC_017333.1\|WP_016187361.1\|1951218_1951965_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NC_017333.1\|WP_000221190.1\|1936207_1936522_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_001168915.1\|1941207_1941843_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	4.66953e-13
NC_017333.1\|WP_000492903.1\|1942009_1942630_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.95394e-14
NC_017333.1\|WP_001032832.1\|1937900_1938755_-\|glucosaminidase-domain-containing-protein	gnl\|CDD\|226656	COG4193, LytD, Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism].	1.03813e-119
NC_017333.1\|WP_000366160.1\|1946731_1947640_-\|NERD-domain-containing-protein	gnl\|CDD\|377990	pfam08378, NERD, Nuclease-related domain. The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.	0.0097287
NC_017333.1\|WP_001261672.1\|1934054_1935557_-\|FAD/NAD(P)-binding-protein	gnl\|CDD\|226906	COG4529, COG4529, Uncharacterized protein conserved in bacteria [Function unknown].	6.46974e-168
NC_017333.1\|WP_001200546.1\|1944721_1945087_+\|fluoride-efflux-transporter-CrcB	gnl\|CDD\|184566	PRK14201, PRK14201, fluoride efflux transporter CrcB.	1.84114e-55
NC_017333.1\|WP_000671058.1\|1939453_1939924_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	4.63508e-17
NC_017333.1\|WP_000989103.1\|1936521_1937814_+\|arsenite-efflux-transporter-membrane-subunit-ArsB	gnl\|CDD\|185342	PRK15445, PRK15445, arsenical efflux pump membrane protein ArsB.	0
NC_017333.1\|WP_000109913.1\|1949329_1950922_+\|phosphoenolpyruvate-carboxykinase-(ATP)	gnl\|CDD\|238270	cd00484, PEPCK_ATP, Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate to yield phosphoenolpyruvate and carbon dioxide, using a nucleotide molecule (ATP) for the phosphoryl transfer, and has a strict requirement for divalent metal ions for activity. PEPCK's separate into two phylogenetic groups based on their nucleotide substrate specificity, this model describes the ATP-dependent groups.	0
NC_017333.1\|WP_001096494.1\|1943192_1943906_-\|transaldolase	gnl\|CDD\|183481	PRK12376, PRK12376, putative translaldolase; Provisional.	1.22733e-152
NC_017333.1\|WP_001153741.1\|1940036_1940480_+\|competence-protein-ComK	gnl\|CDD\|368849	pfam06338, ComK, ComK protein. This family consists of several bacterial ComK proteins. The ComK protein of Bacillus subtilis positively regulates the transcription of several late competence genes as well as comK itself. It has been found that ClpX plays an important role in the regulation of ComK at the post-transcriptional level.	0.00341613
NC_017333.1\|WP_000933822.1\|1947764_1948958_-\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NC_017333.1\|WP_000672013.1\|1951969_1952443_-\|nucleoside-triphosphatase-YtkD	gnl\|CDD\|131752	TIGR02705, conserved_hypothetical_protein, nucleoside triphosphatase YtkD. The functional assignment to the proteins of this family is contentious, with papers disagreeing in both interpretation and enzyme assay results. This protein belongs to the nudix family and shares some sequence identity with E. coli MutT but appears not to be functionally interchangeable with it. [DNA metabolism, DNA replication, recombination, and repair].	1.61742e-84
NC_017333.1\|WP_000453302.1\|1945686_1946520_-\|aldo/keto-reductase	gnl\|CDD\|223729	COG0656, ARA1, Aldo/keto reductases, related to diketogulonate reductase [General function prediction only].	3.63054e-136
NC_017333.1\|WP_000623484.1\|1945083_1945437_+\|CrcB-family-protein	gnl\|CDD\|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	2.17815e-24
NC_017333.1\|WP_016187361.1\|1951218_1951965_-\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	2.57837e-50
NC_017333.1\|WP_000221190.1\|1936207_1936522_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	3.46552e-20

>NC_017333.1|WP_000492903.1|1942009_1942630_+|CPBP-family-intramembrane-metalloprotease
MFSRNNNIFVDDLSVTKDNYLIAVLKMLVIFLVINYGTDVSYDHEYVGLFIILLGVVLLKILNINLLSFKKLKFTHMLYIIFGFLLMYGLDYLYDTFAPPTLNEILIDEESEDAPYHIALLSTAIIPPITEEIICRGLIIRILFRNHLFLGFIVSTVFFTLIHESDTLIGYLPYFYSGLIFGYTYLKTKRLEVPILIHFINNLLAM
>NC_017333.1|WP_001168915.1|1941207_1941843_+|CPBP-family-intramembrane-metalloprotease
MQKFKDLFYDDLSVARGNYFLTLLSAFLITIILLIGFVVSDTHILYGVFIVLIGIVLLRLFKINLLSFKKLTMSQVIYIIGGALLIYGLDYLYLHFHDVPTNEQELDRELQHMPLYMSIVTIAIIPAIVEEIVFRGMIIRVVFRKHLFIGLVVSSLVFASLHESDTWIGYLPYLYSGVIFGLIYLKTKRLEVVILIHFINNLSSLLILLWG
>NC_017333.1|WP_001030474.1|1940466_1940910_-|hypothetical-protein
MNKASFDKKVKKQLWFLNKKEKQALDQRLSSITDKDNVNFNKPITFANTYLRENVFRSKESKSYSIFVTLVVMMFAYVALLGLFLFGLITSLSGVQFFVNPKVDLSTTVVILTIIGAILLMLVSIYLIKITTSYFTKKLLEHKFNGH
>NC_017333.1|WP_001153741.1|1940036_1940480_+|competence-protein-ComK
MQDNSTKYLLYIQTATSNHLETNCVFLHCDYILKVPINKLVSYYAKLHLSSQSVLIETAKNILNINKLVPIYINAKTILFPLKHKRAPIQIYINAHYIVGMTAIENSTLIHFQEGIQLEVDEPFSLVSKKCHESLALKHFIENTNDH
>NC_017333.1|WP_000671058.1|1939453_1939924_+|RNA-polymerase-sigma-factor
MKFNDVYNKHHKIIHHLLKKYNISYNYDEYYQLLLIKMWQLSQIYKPSSNQSLSSFLFMRLNFYLIDLFRQQKRLNDIILCENHSPILTEQPTYFNEYDLRLQDVCALLKHRERQWLMLYLEGYKQYEIADIMSLSTSTIKLIKASVKRKCQRFLN
>NC_017333.1|WP_000384171.1|1939030_1939255_-|hypothetical-protein
MDYAHLNLEHFFARNDDLDVIRDRADFVMINNFTNEMMYRDGQIEGTIDLNQYYYKNRSNAASFIMMDYKKETK
>NC_017333.1|WP_001032832.1|1937900_1938755_-|glucosaminidase-domain-containing-protein
MNKHKKGSIFGIIGLVVIFAVVSFLFFSMISDQIFFKHVKSDIKIEKLNVTLNDAAKKQINNYTSQQVSNKKNDAWRDASATEIKSAMDSGTFIDNEKQKYQFLDLSKYQGIDKNRIKRMLVDRPTLLKHTDDFLKAAKDKHVNEVYLISHALLETGAVKSELANGVEIDGKKYYNFYGVGALDKDPIKTGAEYAKKHGWDTPEKAISGGADFIHKHFLSSTDQNTLYSMRWNPKNPGEHQYATDIKWAESNATIIADFYKNMKTEGKYFKYFVYKDDSKHLKK
>NC_017333.1|WP_000989103.1|1936521_1937814_+|arsenite-efflux-transporter-membrane-subunit-ArsB
MMTTLATFIFLVTLLFVLWQPKGLDIGFTALAGAFIAVITGVVSFSDVFEVTGIVWNATLTFVSVILISLILDKIGFFEWSAIHMLHASKGSGLKMFVYIILLGAVVAAFFANDGAALILTPIVLAMVKNIGFSKRAIFPFIIASGFIADTTSLPLIVSNLVNIISADYFNISFSQYLSRMIIPNLFSLLASLLVLWLYFRKAIPKSFDANHIKKPIDAINDLKLFKISWIVLVILLFGYLISEFTKIPVSIFTGIIAFIFLILARKSNAVNIKQVIKGAPWNIVLFSIGMYIVIFGLRNAGITLILAKILEYISNYGLFSTILGMGFISAFLSSIMNNMPTVLIDAIAIGQSNVHGMLKEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTYFKTGIIITIPVLFFTLIGLYLTLILF
>NC_017333.1|WP_000221190.1|1936207_1936522_+|winged-helix-turn-helix-transcriptional-regulator
MTYKELATYLKVLSDSSRLEILDLLSCGELCACDLLEHFQFSQPTLSYHMKALVKTNLVTTRKIGNKHLYQLNHNIFESVINNLSKVHTSNQRCICHNLKTGEC
>NC_017333.1|WP_001261672.1|1934054_1935557_-|FAD/NAD(P)-binding-protein
MRVAIIGMGTAGVSVLRELVKHPKFNQLDIDLYDDKVNMGQGVPFQNDSSELLINMPSKKMSLNLDDETEFWKWYKQQTDFNFDEPAYLPRFVFGHYMKSYLSMFTKKYPNISTNYNKVQEIYTNSNIDETNLTYYICTTNSEQSWQAYDYVFLTCGTFAYHDPYNLKGKKGYIATPYPTYNTLDEVNELDDIAIIGTGLASLDVVRYVAAHHPKLPITMTSRSANLPSVRGTMIDVTFKYLTKDKLNDIKKHHFGNAPLDTLVSLFLKECAEYDIDFEKLVHRRTGNHIADLKYDLARLTEMGIFQSIIEHLKENLNWIWNSLSIEDQHQFNQKYSKMIQLNSNPMPPRTAELIIELIENKSLILKKDLEDVKHDGKLYYFSYKNQESVDIYKVVINATGAKSHLNELDQDDQLIKNLENRQIVQAHPMGGIQIIPETNQVISPRFGTLTNMIAIGQMTNGVNKLRNGVKMIVEQVAHTVSQLYDALESNEQEQRSDNQ
>NC_017333.1|WP_001096494.1|1943192_1943906_-|transaldolase
MAKLNVEVFADGADIEEMKAAYKNKQVDGFTTNPSLMAKAGVTDYKAFAEEAVKEIPDASISFEVFADDLETMEKEAAILKQYGENVFVKIPIVNTKGESTIPLIKKLSADNVRLNVTAVYTIEQVKEITEAVTEGVPTYVSVFAGRIADTGVDPLPLMKEAVKVTHSKDGVKLLWASCRELFNVIQADEIGADIITCPADVVKKVNTNLGRDINELSVDTVKGFAKDIQSSGLSIL
>NC_017333.1|WP_000091443.1|1944164_1944467_+|hypothetical-protein
MSRSKKYFYLSSLMIILSFFFNTNNVFLSGLFNSFIKLILFCSVINSIILILSIIFADRSIKSLKPDADWIRIASKSLPWIILIVILVHIFSIVHTFGFI
>NC_017333.1|WP_001200546.1|1944721_1945087_+|fluoride-efflux-transporter-CrcB
MQYVYIFIGGALGALLRYLISFLNTDGGFPIGTLIANLTGAFVMGLLTALTIEFFSNHPTLKKAITTGFLGALTTFSTFQLELIHMFDYQQFITLLLYAVTSYVFGILLCYVGIKLGGGLS
>NC_017333.1|WP_000623484.1|1945083_1945437_+|CrcB-family-protein
MISIILVMIGGGLGAIARSAVTDYFNHIFTSKLPIATLIVNLVGSFLIGLTIGLSISISWFPAFFVTGFLGGLTTFSTLAKELTLMMTPKFDIKLFLNYSLLQFIIGFIACYIGYHI
>NC_017333.1|WP_000453302.1|1945686_1946520_-|aldo/keto-reductase
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIRAGLESTGIAREDLFITSKLYFEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAIMVDTWKGMEDLYKNNKVKNIGVSNFEPEHLEALLAQVSIKPVINQVEYHPYLTQHKLKLYLAAQHIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHGVVTIPKSVTPNRISENFRIFDFELSDEQMTRIDDLNQDKRIGPDPKTFEG
>NC_017333.1|WP_000366160.1|1946731_1947640_-|NERD-domain-containing-protein
MDLSSPVVIGLIIAVVIALIFFVLFLVALGSKKKVKRQTEEKYEQQEQNIKKSHEEALEKERIQNKKTITKQQEDYNHMISTKDREIDALKLFSKNHSEYVTDMRLIGIRERLVKEKRIRPEDMHIMANIFLPKDGFNNIERISHLVLTRTGLYIIDSQLLKGHVYNGISGGQFKDLPPMEQVFDTLDLDKSRPQTIVMDQNDDKRSLSFVNYSDQIEAIKQLAEDLQKHLGAKYTPTSILYFNPKNEGDVTISNYNQNSAVKVLVGAEQLDEFFNKFVFHGRIQYNVEDLQQMMDKIESFN
>NC_017333.1|WP_000933822.1|1947764_1948958_-|methionine-adenosyltransferase
MLNNKRLFTSESVTEGHPDKIADQVSDAILDAILKDDPNARVACETTVTTGMALIAGEISTTTYVDIPKVVRETIKEIGYTRAKYGYDYETMAILTAIDEQSPDIAQGVDKALEYRDKDSEEEIEATGAGDQGLMFGYATNETETYMPLAIYLSHQLAKRLSDVRKDGTLNYLRPDGKVQVTVEYDENDNPVRIDTIVVSTQHAEDVTLEQIQEDIKAHVIYPTVPENLINEQTKFYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGCFSGKDPTKVDRSAAYAARYVAKNIVAAGLADQCEVQLAYAIGVAEPVSIAIDTFGTGKVSEGQLVEAVRKHFDLRPAGIIKMLDLKQPIYKQTAAYGHFGRTDVLFPWEKLDKVEELKDAVK
>NC_017333.1|WP_000109913.1|1949329_1950922_+|phosphoenolpyruvate-carboxykinase-(ATP)
MSVDTYTETTKIDKLLKKPTSHFQLSTTQLYNKILDNNEGVLTELGAVNASTGKYTGRSPKDKFFVSEPSYRDNIDWGEINQPIDEETFLKLYHKVLDYLDKKDELYVFKGYAGSDKDTMLKLTVINELAWHNLFAKNMFIRPESKEEATKIKPNFTIVSAPHFKADPEVDGTKSETFVIISFKHKVILIGGTEYAGEMKKGIFSVMNYLLPMQDIMSMHCSANVGEKGDVALFFGLSGTGKTTLSADPHRKLIGDDEHGWNKNGVFNIEGGCYAKAINLSKEKEPQIFDAIKYGAILENTVVSEDGSVDFEDNRYTENTRAAYPINHIDNIVVPSKAAHPNTIIFLTADAFGVIPPISKLNKDQAMYHFLSGFTSKLAGTERGVTEPEPSFSTCFGAPFFPLHPTVYADLLGELIDLHDVDVYLVNTGWTGGKYGVGRRISLHYTRQMVNQAISGKLKNAKYTKDSTFGLSIPVEIEDVPKTILNPINAWSDKEKYKAQAEDLIQRFEKNFEKFGEKVEHIAEKGSFNK
>NC_017333.1|WP_016187361.1|1951218_1951965_-|S9-family-peptidase
MPIESFTHQFEEITYLSDDLQVKALMMTPHHEVKRIVVYLRGGKGQVGRVRAGRLMQFSDSQTLVIGPYYRGNNGSEGKDEFYRGDLNDVTQLLRLLHDKYPQAFIHMVGFSRGGLQGLLTFQDLPVSSYIIWGGVSDIDLMYEERVDLRGMLRRMIGHPKKDRAAYEARQAIPNINENSPPILIVHGGKDQQVGIHHAYYLADQLELKGAAHETFYQMAEGHVPRPPAMVETLTYIKEFMNQVELHR
>NC_017333.1|WP_000672013.1|1951969_1952443_-|nucleoside-triphosphatase-YtkD
MKFRDKDNRQVNLTFKKDNEIADGNHVLAIPTFKNQLLFTKHNLRGIEFPGGKRERGESSAEAVTRELYEETGAKVKNIHYIAQYTIETHDQTDFVKDVYFIEVESLVSKNDYLETAGPVLFNCINDIELAQRSFLLQDSTILKCVERVQSLGFYQT

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Crispr_ID: NC_017333_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_8

2212067-2212279

Orphan

Consensus_repeat	Method
TGATGTGCTGTTGTGGAAGCTTGGTGTCGTGCCATGCTACTTTGATG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_017333_8

>merge|NC_017333|8|2212067-2212279|CRISPRCasFinder
TGACGTATTGTTGCGGGAACTTGGTGTCATGACATGTTACTTTGATGTGCTGGTACCACGATGCGTCTTGATGTAGTGCTATGATGTGCTGTTGTGGAAGCTTGGTGTCGTGCCATGCTACTTTGATGTGCTGTTGTGGGAGCTTGGTGTTGGTGCCATGTTACTTTGATGTGCTGTTGTGGAAGCTTGGTGTCATGCCATGCTACTTTGATG

>NC_017333|8|8|2212067-2212279|CRISPRCasFinder
TGACGTATTGTTGCGGGAACTTGGTGTCATGACATGTTACTTTGATG	TGCTGGTACCACGATGCGTCTTGATGTAGTGCTA
TGATGTGCTGTTGTGGAAGCTTGGTGTCGTGCCATGCTACTTTGATG	TGCTGTTGTGGGAGCTTGGTGTTGGTGCCATGTTACTT
TGATGTGCTGTTGTGGAAGCTTGGTGTCATGCCATGCTACTTTGATG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_001178939.1\|2202668_2204189_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NC_017333.1\|WP_000396068.1\|2217473_2218163_-\|thiaminase-II	unknown	unknown	gnl\|CDD\|213919
NC_017333.1\|WP_000828354.1\|2208928_2209066_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_001187614.1\|2211385_2212033_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NC_017333.1\|WP_000447678.1\|2220719_2221160_-\|3-hydroxyacyl-ACP-dehydratase-FabZ	unknown	unknown	gnl\|CDD\|234568
NC_017333.1\|WP_001825748.1\|2212312_2212633_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_001109939.1\|2207462_2208665_+\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NC_017333.1\|WP_000932694.1\|2219633_2220029_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|366099
NC_017333.1\|WP_000138932.1\|2209414_2209708_-\|copper-sensing-transcriptional-repressor-CsoR	unknown	unknown	gnl\|CDD\|197387
NC_017333.1\|WP_001190840.1\|2201620_2202316_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_017333.1\|WP_000594965.1\|2216650_2217481_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180561
NC_017333.1\|WP_000483161.1\|2215232_2215874_-\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|234590
NC_017333.1\|WP_000846746.1\|2220222_2220663_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379494
NC_017333.1\|WP_000571550.1\|2209873_2211358_+\|cardiolipin-synthase	unknown	unknown	gnl\|CDD\|211988
NC_017333.1\|WP_001108486.1\|2215875_2216667_-\|hydroxyethylthiazole-kinase	unknown	unknown	gnl\|CDD\|236477
NC_017333.1\|WP_000751995.1\|2218549_2219245_-\|lytic-transglycosylase-SceD	unknown	unknown	gnl\|CDD\|369056
NC_017333.1\|WP_000611457.1\|2204704_2206060_-\|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase	unknown	unknown	gnl\|CDD\|223841
NC_017333.1\|WP_000725800.1\|2214274_2215147_-\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|235040
NC_017333.1\|WP_000581792.1\|2209193_2209403_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|238219
NC_017333.1\|WP_000159641.1\|2206074_2207145_-\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234993

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_001178939.1\|2202668_2204189_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	7.40342e-159
NC_017333.1\|WP_000396068.1\|2217473_2218163_-\|thiaminase-II	gnl\|CDD\|213919	TIGR04306, salvage_TenA, thiaminase II. The TenA protein of Bacillus subtilis and Staphylococcus aurues, and the C-terminal region of trifunctional protein Thi20p from Saccharomyces cerevisiae, perform cleavages on thiamine and related compounds to produce 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), a substrate a salvage pathway for thiamine biosynthesis. The gene symbol tenA, for Transcription ENhancement A, reflects a misleading early characterization as a regulatory protein. This family is related to PqqC from the PQQ biosynthesis system (see TIGR02111), heme oxygenase (pfam01126), and CADD (Chlamydia protein Associating with Death Domains), a putative folate metabolism enzyme (see TIGR04305).	1.05378e-100
NC_017333.1\|WP_000846746.1\|2220222_2220663_+\|hypothetical-protein	gnl\|CDD\|379494	pfam14183, YwpF, YwpF-like protein. The YwpF-like protein family includes the B. subtilis YwpF protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 146 and 167 amino acids in length. There is a conserved IIN sequence motif.	1.15589e-56
NC_017333.1\|WP_001187614.1\|2211385_2212033_+\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	2.00474e-42
NC_017333.1\|WP_001109939.1\|2207462_2208665_+\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	3.51677e-108
NC_017333.1\|WP_000932694.1\|2219633_2220029_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|366099	pfam00436, SSB, Single-strand binding protein family. This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA.	9.06157e-32
NC_017333.1\|WP_000138932.1\|2209414_2209708_-\|copper-sensing-transcriptional-repressor-CsoR	gnl\|CDD\|197387	cd10152, SaCsoR-like_DUF156, Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156. This domain family includes Staphylococcus aureus CsoR (SaCsoR). SaCsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis; it represses a genetically unlinked copA-copZ operon. copA encodes a copper efflux P-type ATPase, and copZ, a copper chaperone. This family belongs to a larger superfamily that contains various transcriptional regulators that respond to different stressors such as Cu(I), Ni(I), sulfite, and formaldehyde, and includes Mycobacterium tuberculosis CsoR (MtCsoR), Bacillus subtilis CsoR, and Thermus thermophilus CsoR. The latter three proteins do not belong to this family. CsoRs form homotetramers (dimer of dimers). In MtCsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily, including this family, and a conserved Tyr and a Glu residue that facilitate allosteric regulation of DNA binding for CsoRs are also well conserved.	8.02331e-35
NC_017333.1\|WP_001190840.1\|2201620_2202316_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.28552e-68
NC_017333.1\|WP_000594965.1\|2216650_2217481_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	1.38659e-148
NC_017333.1\|WP_000483161.1\|2215232_2215874_-\|thiamine-phosphate-synthase	gnl\|CDD\|234590	PRK00043, thiE, thiamine phosphate synthase.	5.71532e-89
NC_017333.1\|WP_000447678.1\|2220719_2221160_-\|3-hydroxyacyl-ACP-dehydratase-FabZ	gnl\|CDD\|234568	PRK00006, fabZ, 3-hydroxyacyl-ACP dehydratase FabZ.	8.27669e-92
NC_017333.1\|WP_000571550.1\|2209873_2211358_+\|cardiolipin-synthase	gnl\|CDD\|211988	TIGR04265, bac_cardiolipin, cardiolipin synthase. This model is based on experimentally characterized bacterial cardiolipin synthases (cls) from E. coli, Staphylococcus aureus (two), and Bacillus pseudofirmus OF4. This model describes just one of several homologous but non-orthologous forms of cls. The cutoff score is set arbitrarily high to avoid false-positives. Note that there are two enzymatic activites called cardiolipin synthase. This model represents type 1, which does not rely on a CDP-linked donor, but instead does a reversible transfer of a phosphatidyl group from one phosphatidylglycerol molecule to another.	0
NC_017333.1\|WP_001108486.1\|2215875_2216667_-\|hydroxyethylthiazole-kinase	gnl\|CDD\|236477	PRK09355, PRK09355, hydroxyethylthiazole kinase; Validated.	7.69146e-123
NC_017333.1\|WP_000751995.1\|2218549_2219245_-\|lytic-transglycosylase-SceD	gnl\|CDD\|369056	pfam06737, Transglycosylas, Transglycosylase-like domain. This family of proteins are very likely to act as transglycosylase enzymes related to pfam00062 and pfam01464. These other families are weakly matched by this family, and include the known active site residues.	6.44668e-24
NC_017333.1\|WP_000611457.1\|2204704_2206060_-\|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase	gnl\|CDD\|223841	COG0770, MurF, UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane].	0
NC_017333.1\|WP_000159641.1\|2206074_2207145_-\|D-alanine--D-alanine-ligase	gnl\|CDD\|234993	PRK01966, ddl, D-alanine--D-alanine ligase.	0
NC_017333.1\|WP_000581792.1\|2209193_2209403_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	0.000383249
NC_017333.1\|WP_000725800.1\|2214274_2215147_-\|membrane-protein-insertase-YidC	gnl\|CDD\|235040	PRK02463, PRK02463, OxaA-like protein precursor; Provisional.	7.06711e-64

>NC_017333.1|WP_001187614.1|2211385_2212033_+|HD-domain-containing-protein
MQQSDIISAAKKYMESIHQNDYTGHDIAHVYRVTALAKSIAENEGVNDTLVIELACLLHDTVDEKVVDANKQYAELKSFLSSLSLSTEDQEHILFIINNMSYRNGKNDHVTLTLEGQIVRDADRLDAIGAIGVARTFQFAGHFGEPMWTEQMSLDKINDDLVEQLPPSAIKHFFEKLLKLESLMHTDTAKMIAKERHDFMMIYLKQFFTEWNYHD
>NC_017333.1|WP_000571550.1|2209873_2211358_+|cardiolipin-synthase
MIELLSIALKHSNIILNSIFIGAFILNLLFAFTIIFMERRSANSIWAWLLVLVFLPLFGFILYLLLGRQIQRDQIFKIDKEDKKGLELIVDEQLAALKNENFSNSNYQIVKFKEMIQMLLYNNAAFLTTDNDLKIYTDGQEKFDDLIQDIRNATDYIHFQYYIIQNDELGRTILNELGKKAEQGVEVKILYDDMGSRGLRKKGLRPFRNKGGHAEAFFPSKLPLINLRMNNRNHRKIVVIDGQIGYVGGFNVGDEYLGKSKKFGYWRDTHLRIVGDAVNALQLRFILDWNSQATRDHISYDDRYFPDVNSGGTIGVQIASSGPDEEWEQIKYGYLKMISSAKKSIYIQSPYFIPDQAFLDSIKIAALGGVDVNIMIPNKPDHPFVFWATLKNAASLLDAGVKVFHYDNGFLHSKTLVIDDEIASVGTANMDHRSFTLNFEVNAFIYDQQIAKKLKQAFIDDLAVSSELTKARYANRSLWIKFKEGISQLLSPIL
>NC_017333.1|WP_000138932.1|2209414_2209708_-|copper-sensing-transcriptional-repressor-CsoR
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQEEAMEELLVTFQKLIKD
>NC_017333.1|WP_000581792.1|2209193_2209403_-|heavy-metal-associated-domain-containing-protein
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
>NC_017333.1|WP_000828354.1|2208928_2209066_-|hypothetical-protein
MKRPEKIQNVVKLLSSLGVNIKKTKSRLDIINTLPASNKVSHELK
>NC_017333.1|WP_001109939.1|2207462_2208665_+|rod-shape-determining-protein-RodA
MNYSSRQQPDKHWLRKVDWVLVATIAVLAIFSVLLINSAMGGGQYSANFGIRQIFYYILGAIFAGIIMFISPKKIKHYTYLLYFLICLLLIGLLVIPESPITPIINGAKSWYTFGPISIQPSEFMKIILILALARVVSRHNQFTFNKSFQSDLLLFFKIIGVSLVPSILILLQNDLGTTLVLAAIIAGVMLVSGITWRILAPIFITGIVGAMTVILGILYAPALIENLLGVQLYQMGRINSWLDPYTYSSGDGYHLTESLKAIGSGQLLGKGYNHGEVYIPENHTDFIFSVIGEELGFIGSVILILIFLFLIFHLIRLAAKIEDQFNKIFIVGFVTLLVFHILQNIGMTIQLLPITGIPLPFISYGGSALWSMMTGIGIVLSIYYHEPKRYVDLYHPKSN
>NC_017333.1|WP_000159641.1|2206074_2207145_-|D-alanine--D-alanine-ligase
MTKENICIVFGGKSAEHEVSILTAQNVLNAIDKDKYHVDIIYITNDGDWRKQNNITTEIKSTDELHLENGEALEISQLLKESSSGQPYDAVFPLLHGPNGEDGTIQGLFEVLDVPYVGNGVLSAASSMDKLVMKQLFEHRGLPQLPYISFLRSEYEKYEHNILKLVNDKLNYPVFVKPANLGSSVGISKCNNEAELKEGIKEAFQFDRKLVIEQGVNAREIEVAVLGNDYPEATWPGEVVKDVAFYDYKSKYKDGKVQLQIPADLDEDVQLTLRNMALEAFKATDCSGLVRADFFVTEDNQIYINETNAMPGFTAFSMYPKLWENMGLSYPELITKLIELAKERHQDKQKNKYKID
>NC_017333.1|WP_000611457.1|2204704_2206060_-|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase
MINVTLKQIQSWIPCEIEDQFLNQEINGVTIDSRAISKNMLFIPFKGENVDGHRFVSKALQDGAGAAFYQKGTPIDENVSGPIIWVEDTLTALQQLAQAYLRHVNPKVIAVTGSNGKTTTKDMIESVLHTEFKVKKTQGNYNNEIGLPLTILELDNDTEISILEMGMSGFHEIEFLSNLAQPDIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEVENAKCISIGVATDNALVCSVDDRDTTGISFTINNEHYDLPILGKHNMKNATIAIAVGHELGLTYNIIYQNLKNVSLTGMRMEQHTLENDITVINDAYNASPTSMRAAIDTLSTLTGRRILILGDVLELGENSKEMHIGVGNYLEEKHIDVLYTFGNEAKYIYDSGQQHVEKAQHFNSKDDMIEVLTSDLKAHDRVLVKGSRGMKLEEVVNALIS
>NC_017333.1|WP_001178939.1|2202668_2204189_-|DEAD/DEAH-box-helicase
MQNFKELGISDNTVQSLESMGFKEPTPIQKDSIPYALQGIDILGQAQTGTGKTGAFGIPLIEKVVGKQGVQSLILAPTRELAMQVAEQLREFSRGQGVQVVTVFGGMPIERQIKALKKGPQIVVGTPGRVIDHLNRRTLKTDGIHTLILDEADEMMNMGFIDDMRFIMDKIPAVQRQTMLFSATMPKAIQALVQQFMKSPKIIKTMNNEMSDPQIEEFYTIVKELEKFDTFTNFLDVHQPELAIVFGRTKRRVDELTSALISKGYKAEGLHGDITQAKRLEVLKKFKNDQINILVATDVAARGLDISGVSHVYNFDIPQDTESYTHRIGRTGRAGKEGIAVTFVNPIEMDYIRQIEDANGRKMSALRPPHRKEVLQAREDDIKEKVENWMSKDSESRLKRISTELLNEYNDVDLVAALLQELVEANDEVEVQLTFEKPLSRKGRNGKPSGSRNRNSKRGNPKFDSKSKRSKGYSSKKKSTKKFDRKEKSSGGSRPMKGRTFADHQK
>NC_017333.1|WP_001190840.1|2201620_2202316_+|response-regulator-transcription-factor
MQSKILIIEDDHAITHLLDVALTLDYYNVTTADNATQAHFKIQIDKPDVILLDLGLPDKDGLCLISEIRQHTDIPIIVISARQEEQTIIQALDNGANDYMTKPFNVDELRARIRVIERIAKSHQETNFVFTNGLLSIDFGSKSVVINNQEVHLTPNEFSLLELLSNHKGKVLTYEMILKRIYGYVNKTEMPSLRVHMTSLRQKLSQCHEDAKDIIKTHPRIGYQMLQWKEK
>NC_017333.1|WP_001825748.1|2212312_2212633_+|hypothetical-protein
MIWRCGVMGGIARGIDAMPLQFYDMALGRCNVYYAVVTLLFHTVTCICELLWKCCDIYCYTDESLCQDDIAMMNSNSVINHFLHAEISLILFGSMSNWTDAFNIGS
>NC_017333.1|WP_000725800.1|2214274_2215147_-|membrane-protein-insertase-YidC
MKKKALLPLFLGIMVFLAGCDYSKPEKRSGFFYNTFVDPMKNVLDWLGNNLLNDNYGLAIIILVLVIRIILLPFMLSNYKNSHMMRQKMKVAKPEVEKIQEKVKRARTQEEKMAANQELMQVYKKYDMNPIKSMLGCLPMLIQLPIIMGLYFVLKDQLVDGLFKYPHFLWFDLGRPDIWITIIAGVLYFIQAYVSSKTMPDEQRQMGYMMMVISPIMIIWISLSSASALGLYWSVSAAFLVVQTHFANIYYEKVAKKEVQPFIEAYEREHNGGNNKKGKNTQVVSKKKKK
>NC_017333.1|WP_000483161.1|2215232_2215874_-|thiamine-phosphate-synthase
MFNQSYLNVYFICGTSDVPSHRTIHEVLEAALKAGITLFQFREKGESALKGNDKLVLAKELQHLCHQYDVPFIVNDDVSLAKEINADGIHVGQDDAKVKEIAQYFTDKIIGLSISDLGEYAKSDLTHVDYIGVGPIYPTPSKNDAHTPVGPEMIATFKEMNPQLPIVAIGGINTSNVAPIVEAGANGISVISAISKSENIEKTVNRFKDFFNN
>NC_017333.1|WP_001108486.1|2215875_2216667_-|hydroxyethylthiazole-kinase
MNYLNKIRIENPLTICYTNDVVKNFTANGLLSIGASPAMSEAPEEAEEFYKVAQALLINIGTLTAQNEQDIIAIAQTANEAGLPIVFDPVAVGASTYRKQFCKLLLKSAKVSVIKGNASEILALIDDTATMKGTDSDANLDAVAIAKKAYAIYKTAIVITGKEDVIVQGDKAIVLANGSPLLARVTGAGCLLGGVIAGFLFRETEPDIEALIEAVSVFNIAAEVAAENENCGGPGTFSPLLLDTLYHLNETTYQQRIRIQEVE
>NC_017333.1|WP_000594965.1|2216650_2217481_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MIKPKIALTIAGTDPTGGAGVMADLKSFHSCGVYGMGVVTSIVAQNTLGVQNIHNLNHQWVDEQLDSVFNDTLPHAIKTGMIATADTMETIRHYLMQHESIPYVIDPVMLAKSGDSLMDNDTKQNLQHTLLPLADVVTPNLPEAEEITGLTIDSEEKIMQAGRIFINEIGSKGVIVKGGHSNDTDIAKDYLFTKEGVQTFENERFKTKHTHGTGCTFSAVITAELAKGRPLFDAVQKAKKFISMSIQYTPEIGRGRGPVNHFAYLKKEGLDDELSK
>NC_017333.1|WP_000396068.1|2217473_2218163_-|thiaminase-II
MEFSQKLYQAAKPIINDIYEDDFIQKMLLGNIQADALRHYLQADAAYLKEFTNLYALLIPKMNSMNDVKFLVEQIEFMVEGEVLAHDILAQIVGESYEEIIKTKVWPPSGDHYIKHMYFQAHSRENAIYTIAAMAPCPYIYAELAKRSQSDHKLNREKDTAKWFDFYSTEMDDIINVFESLMNKLAESMSDKELEQVKQVFLESCIHERRFFNMAMTLEQWEFGGKVND
>NC_017333.1|WP_000751995.1|2218549_2219245_-|lytic-transglycosylase-SceD
MKKTLLASSLAVGLGIVAGNAGHEAHASEADLNKASLAQMAQSNDQTLNQKPIEAGAYNYTFDYEGFTYHFESDGTHFAWNYHATGANGADMSAQAPATNNVAPSADQANQVQSQEVEAPQNAQTQQPQASTSNNSQVTATPTESKASEGSSVNVNDHLKQIAQRESGGNIHAVNPTSGAAGKYQFLQSTWDSVAPAKYKGVSPANAPESVQDAAAVKLYNTGGAGHWVTA
>NC_017333.1|WP_000932694.1|2219633_2220029_-|single-stranded-DNA-binding-protein
MLNKIVIVGRLTKDAQIFEKEDRKIATFCVATHRNYKDENGEIVCDYLFCKAFGKLASNIEKYTNQGTLVGITGQMRSRKYDKDGQTHFVTELYVETIKFMSPKSQNNEILSDSILDIDSQNIDNHDLLEI
>NC_017333.1|WP_000846746.1|2220222_2220663_+|hypothetical-protein
MKTFKAVRFQIVNEHGRIIEYELEDGVIINKEESGTGWLLEIVISNEHYETFKEYQDNEQLLDIRVVITRPANDPALFESTVKSIKNFKTTMSIVFECHIYTLRQQYAESLLEQLIDDGLSGEELKKSFNRMMQSKPKLKDEKLEE
>NC_017333.1|WP_000447678.1|2220719_2221160_-|3-hydroxyacyl-ACP-dehydratase-FabZ
METIFDYNQIKQIIPHRQPFLLIDKVVEYEEGQRCVAIKQVSGNEPFFQGHFPEYAVMPGVLITEALAQTGAVAILNSEENKGKIALFAGIDKCRFKRQVVPGDTLTLEVEITKIKGPIGKGNAKATVDGQLACSCELTFAIQDVK

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Crispr_ID: NC_017333_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_9

2267698-2267848

Orphan

Consensus_repeat	Method
AACTTTAGTTGTTAGGGGCTCTTATGCA	CRISPRCasFinder

2 spacers

csa3,TnsE_C

The CRISPR arrays of NC_017333_9

>merge|NC_017333|9|2267698-2267848|CRISPRCasFinder
AACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTACTTTTAAACTTTAGTTGTAAGGGGCTCTTATGCAGTTGATGCATAGCATCCAACTGTGTTCCTCTATTTTTCAACTTTAGTTGTTAGGAGCTTCTTTCTA

>NC_017333|9|9|2267698-2267848|CRISPRCasFinder
AACTTTAGTTGTTAGGGGCTCTTATGCA	TGCGCTTAGCGCAGGCGCTCCTACTTTTA
AACTTTAGTTGTAAGGGGCTCTTATGCA	GTTGATGCATAGCATCCAACTGTGTTCCTCTATTTTTC
AACTTTAGTTGTTAGGAGCTTCTTTCTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_001123309.1\|2259654_2260068_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NC_017333.1\|WP_000101714.1\|2271774_2272383_-\|TIR-domain-containing-protein	unknown	unknown	gnl\|CDD\|378100
NC_017333.1\|WP_001792784.1\|2268961_2269120_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_099184063.1\|2275067_2275358_-\|DUF3387-domain-containing-protein	unknown	unknown	gnl\|CDD\|378743
NC_017333.1\|WP_001127960.1\|2262831_2263770_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NC_017333.1\|WP_000019735.1\|2265342_2266323_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NC_017333.1\|WP_000003759.1\|2265020_2265341_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_017333.1\|WP_000370942.1\|2269777_2270635_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NC_017333.1\|WP_000160304.1\|2258180_2258891_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_017333.1\|WP_000876896.1\|2272410_2273445_-\|toll/interleukin-1-receptor-domain-containing-protein	unknown	unknown	gnl\|CDD\|379328
NC_017333.1\|WP_001024099.1\|2264203_2264869_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NC_017333.1\|WP_000123402.1\|2260525_2261899_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NC_017333.1\|WP_000220902.1\|2269555_2269648_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_001156920.1\|2275482_2275887_-\|hypothetical-protein	TnsE_C	TnsE	gnl\|CDD\|376049
NC_017333.1\|WP_001802298.1\|2268177_2268282_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000495673.1\|2266588_2267680_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000808818.1\|2262570_2262801_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000070865.1\|2259011_2259455_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NC_017333.1\|WP_000908191.1\|2270702_2271485_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_017333.1\|WP_044555027.1\|2273538_2275008_-\|SIR2-family-protein	unknown	unknown	gnl\|CDD\|375615

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_001123309.1\|2259654_2260068_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	5.06041e-44
NC_017333.1\|WP_044555027.1\|2273538_2275008_-\|SIR2-family-protein	gnl\|CDD\|375615	pfam18185, STALD, Sir2- and TIR-associating SLOG family. Family in the SLOG superfamily, associating with predicted Sir2- and TIR-like effector domains. Members of this family are predicted to functions as sensors of nucleotide or nucleotide-derived ligands, which are likely processed or modified by the associating effectors.	2.28367e-76
NC_017333.1\|WP_001127960.1\|2262831_2263770_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	7.24075e-129
NC_017333.1\|WP_000019735.1\|2265342_2266323_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.75655e-109
NC_017333.1\|WP_000003759.1\|2265020_2265341_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
NC_017333.1\|WP_000101714.1\|2271774_2272383_-\|TIR-domain-containing-protein	gnl\|CDD\|378100	pfam08937, DUF1863, MTH538 TIR-like domain (DUF1863). This domain adopts the flavodoxin fold, that is, five parallel beta-strands and four helical segments. The structure is a three-layer sandwich with alpha-1 and alpha-4 on one side of the beta-sheet, and alpha-2 and alpha-3 on the other side. Probable role in signal transduction as a phosphorylation-independent conformational switch protein. This domain is similar to the TIR domain.	5.23558e-19
NC_017333.1\|WP_000160304.1\|2258180_2258891_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
NC_017333.1\|WP_000876896.1\|2272410_2273445_-\|toll/interleukin-1-receptor-domain-containing-protein	gnl\|CDD\|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	2.54926e-06
NC_017333.1\|WP_001024099.1\|2264203_2264869_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	7.27205e-48
NC_017333.1\|WP_000123402.1\|2260525_2261899_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.86989e-06
NC_017333.1\|WP_000370942.1\|2269777_2270635_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	6.61293e-60
NC_017333.1\|WP_099184063.1\|2275067_2275358_-\|DUF3387-domain-containing-protein	gnl\|CDD\|378743	pfam11867, DUF3387, Domain of unknown function (DUF3387). This domain is functionally uncharacterized. This domain is found in bacteria and archaea. This presumed domain is typically between 255 to 340 amino acids in length. This domain is found associated with pfam04851, pfam04313.	2.17206e-37
NC_017333.1\|WP_000908191.1\|2270702_2271485_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.99209e-106
NC_017333.1\|WP_000070865.1\|2259011_2259455_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	5.87929e-68
NC_017333.1\|WP_001156920.1\|2275482_2275887_-\|hypothetical-protein	gnl\|CDD\|376049	pfam18623, TnsE_C, TnsE C-terminal domain. The bacterial transposon Tn7 facilitates horizontal transfer by directing transposition into actively replicating DNA with the element-encoded protein TnsE. Structural analysis of the C-terminal domain of TnsE identified a central V-shaped loop that toggles between two distinct conformations. It is suggested that a conformational change within the C-terminal domain of TnsE underlies target site selection by regulating stable engagement of the target DNA while providing a signal for activating transposition.	5.43167e-08

>NC_017333.1|WP_000495673.1|2266588_2267680_+|hypothetical-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQTIAIYSQFGQKPPGDAYLKVIALLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLVGIAITTQSIIIIVVLLIKAIITWLLLIPVFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILYVVIHAIILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NC_017333.1|WP_000019735.1|2265342_2266323_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHHDHMHSHVNTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNATATKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHVH
>NC_017333.1|WP_000003759.1|2265020_2265341_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NC_017333.1|WP_001024099.1|2264203_2264869_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFEGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGDQDIKDALTQFENETD
>NC_017333.1|WP_001127960.1|2262831_2263770_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>NC_017333.1|WP_000808818.1|2262570_2262801_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQTSASLKFSALLINVLPLCGTFVASN
>NC_017333.1|WP_000123402.1|2260525_2261899_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NC_017333.1|WP_001123309.1|2259654_2260068_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQQPEAANKNSVILQKGDRIYFESQAIIQLITALPNRTKLLGVGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NC_017333.1|WP_000070865.1|2259011_2259455_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLEKAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NC_017333.1|WP_000160304.1|2258180_2258891_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NC_017333.1|WP_001802298.1|2268177_2268282_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NC_017333.1|WP_001792784.1|2268961_2269120_+|hypothetical-protein
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>NC_017333.1|WP_000220902.1|2269555_2269648_+|hypothetical-protein
MTYGSIVAILCALFAIFFIPYMEKKDKKKK
>NC_017333.1|WP_000370942.1|2269777_2270635_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLREKGYKVFLATGRSHSEIHQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKRQQIYYEVFPFEGNRVSLKEDETWLRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIEHFGINQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NC_017333.1|WP_000908191.1|2270702_2271485_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINGGDKWILYGLNGAGKTTLLNILNAYEPATTGSVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEVRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NC_017333.1|WP_000101714.1|2271774_2272383_-|TIR-domain-containing-protein
MARKTFISYKYSEAKDLRDKIVESLGEDAKYYQGETSDSPDMSDRITEYIKKELKNKIYSTSVTIVVISPNMKESNWIDWEIEYSVKQMKRGDRTSSTNGVVGVVMKHNGDYSWLRNSVINSDGHTAIHTDNSYLYDIIVKNRFNQEPIEYTCDECKNIDALTGSFISLVEEDEFLGNPTKYIENAYEKSKKATNYNICRRK
>NC_017333.1|WP_000876896.1|2272410_2273445_-|toll/interleukin-1-receptor-domain-containing-protein
MKYPIRQVAEVLPEKYTRYILLKEFQRLFPYQWNIIVERQQTYKEKAQHLYKVKKIKNRYNTKSAEEYFFSIPQVKYILSAGRMKKHKENYNASEIKIKKAALEKSRKNKNWKIEERLIKAKRYTQKVDPEYLNIYMKAYHKKDITTEEKLEILTELKKFDTENIVRFFRKLNDAEQNKMIRNLAFKYLQDYGHYVKLRKNFKGKKKVYQTERASLDTKKPEDLYNDLTNKNIQSQKVYDIFISHSTKDKKTVEDIIRVFNEQNKTCYCDWTMDQDYLKRKYVGEYTKQVLKARMEQSKMLVLLRTENSVQSDWVSFEIEYFENLKKPIYIVESLEELLEAFSD
>NC_017333.1|WP_044555027.1|2273538_2275008_-|SIR2-family-protein
MNGDGKMTIDKKKFIEKYVKALESNTAAIFAGAGLSCGAGYVNWKTLLNEAAEELELNIDKEEHDLVGLAQHYINKKRSRGNLNTVIMEQFSTRAELTENHKLLAKLPIDTYWTTNYDCMIEKALDSEGRIVDVKRNQNQLTVSVADKDATVYKMHGDIDSIDKIILTRDDYEKYNLTHPKFREILEGDLLSKTFLFIGFSFTDPNISYILSRIRLVLEDNTRPHYCILKEVEEKEYDNTEEFMYAKIKQQLHIEDLSRFSIETLLVKDYIEITEILESIYKRYRRKTIFISGSATEYLPFNSETGKYFLHQLSKKLVENDFKLVTGFGLGVGSYVINGVADYINSNKKSKLQNHLNILPFSQDSSGDLDLKEVWKKNRLEMISECGMALFLFGNKEKDGKIVLADGLEEEYKIAERQELVRLPINVTGYKTKNLSEQYNEEINIQFKEKILKMYNEINEYKCDFSNKQSIDELVQKIVNLVIEIKKTK
>NC_017333.1|WP_099184063.1|2275067_2275358_-|DUF3387-domain-containing-protein
MVMEENAFYDALASHDTAEHVLGDDTLKIIAHELTQSIKENMSIDWNLCESARAKMRVIVRRLLKKYGYPPEISKQAVETVIEQAELMSEQLAMEL
>NC_017333.1|WP_001156920.1|2275482_2275887_-|hypothetical-protein
MQELEDYKEVQLIIIQMSSLPIGDGKRVFSYLEDGVTPRQYALATVSLFNGNEFKILEVERENCALSMLILSSTGLVNWNPLIDSLLLNLVNSSGTWVKESLEILERSNVIIQKAKHSKKEYAHRAKLLIHKML

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Crispr_ID: NC_017333_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_10

2431719-2431804

Orphan

Consensus_repeat	Method
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NC_017333_10

>merge|NC_017333|10|2431719-2431804|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGGCGGGGCCCCAACATAGAAGCTGGCGGAAAGTCAGCTTACAATAATGTGCAAGTTGG

>NC_017333|10|10|2431719-2431804|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CGGGGCCCCAACATAGAAGCTGGCGG
AAAGTCAGCTTACAATAATGTGCAAGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_001030125.1\|2439573_2440266_+\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_017333.1\|WP_000921246.1\|2432754_2432988_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000737699.1\|2428315_2428816_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NC_017333.1\|WP_000840813.1\|2433282_2433756_-\|DUF1641-domain-containing-protein	unknown	unknown	gnl\|CDD\|225283
NC_017333.1\|WP_000032840.1\|2420252_2420996_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|130944
NC_017333.1\|WP_000684154.1\|2430223_2431348_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|168661
NC_017333.1\|WP_001155267.1\|2433755_2436710_-\|formate-dehydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|225918
NC_017333.1\|WP_000417008.1\|2429178_2430132_+\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240655
NC_017333.1\|WP_000606724.1\|2441076_2441406_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000073196.1\|2441850_2442723_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NC_017333.1\|WP_000130460.1\|2438391_2439189_-\|inositol-monophosphatase	unknown	unknown	gnl\|CDD\|223559
NC_017333.1\|WP_000206106.1\|2427656_2428079_+\|DUF4870-domain-containing-protein	unknown	unknown	gnl\|CDD\|225833
NC_017333.1\|WP_000426692.1\|2440290_2441028_-\|CPBP-family-intramembrane-metalloprotease-SdpB	unknown	unknown	gnl\|CDD\|376806
NC_017333.1\|WP_000599591.1\|2419862_2420189_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|379617
NC_017333.1\|WP_000831053.1\|2437311_2438259_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|181811
NC_017333.1\|WP_000684571.1\|2426326_2427409_-\|NAD/NADP-octopine/nopaline-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|376763
NC_017333.1\|WP_000717395.1\|2423585_2424395_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NC_017333.1\|WP_000739235.1\|2431956_2432733_-\|glucosaminidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|226656
NC_017333.1\|WP_001826088.1\|2424463_2424658_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000988992.1\|2424831_2426232_-\|Na+/H+-antiporter-NhaC	unknown	unknown	gnl\|CDD\|188097

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_001030125.1\|2439573_2440266_+\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	3.1353e-57
NC_017333.1\|WP_000737699.1\|2428315_2428816_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	3.97694e-33
NC_017333.1\|WP_000840813.1\|2433282_2433756_-\|DUF1641-domain-containing-protein	gnl\|CDD\|225283	COG2427, COG2427, Uncharacterized conserved protein [Function unknown].	1.05607e-29
NC_017333.1\|WP_000032840.1\|2420252_2420996_-\|transcriptional-regulator	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	2.02961e-26
NC_017333.1\|WP_000684154.1\|2430223_2431348_-\|FAD-dependent-monooxygenase	gnl\|CDD\|168661	PRK06753, PRK06753, hypothetical protein; Provisional.	0
NC_017333.1\|WP_001155267.1\|2433755_2436710_-\|formate-dehydrogenase-subunit-alpha	gnl\|CDD\|225918	COG3383, COG3383, Uncharacterized anaerobic dehydrogenase [General function prediction only].	0
NC_017333.1\|WP_000417008.1\|2429178_2430132_+\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240655	cd12178, 2-Hacid_dh_13, Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	0
NC_017333.1\|WP_000073196.1\|2441850_2442723_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	1.12128e-80
NC_017333.1\|WP_000130460.1\|2438391_2439189_-\|inositol-monophosphatase	gnl\|CDD\|223559	COG0483, SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism].	7.03254e-72
NC_017333.1\|WP_000206106.1\|2427656_2428079_+\|DUF4870-domain-containing-protein	gnl\|CDD\|225833	COG3296, COG3296, Uncharacterized protein conserved in bacteria [Function unknown].	7.90586e-53
NC_017333.1\|WP_000426692.1\|2440290_2441028_-\|CPBP-family-intramembrane-metalloprotease-SdpB	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.30887e-10
NC_017333.1\|WP_000599591.1\|2419862_2420189_-\|PH-domain-containing-protein	gnl\|CDD\|379617	pfam14470, bPH_3, Bacterial PH domain. Proteins in this family are distantly related to PH domains.	0.00124337
NC_017333.1\|WP_000831053.1\|2437311_2438259_-\|LCP-family-protein	gnl\|CDD\|181811	PRK09379, PRK09379, LytR family transcriptional regulator.	2.88129e-98
NC_017333.1\|WP_000684571.1\|2426326_2427409_-\|NAD/NADP-octopine/nopaline-dehydrogenase-family-protein	gnl\|CDD\|376763	pfam02317, Octopine_DH, NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain. This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. The Pfam family consists mainly of octopine and nopaline dehydrogenases from Ti plasmids.	2.04121e-47
NC_017333.1\|WP_000717395.1\|2423585_2424395_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	9.81396e-31
NC_017333.1\|WP_000739235.1\|2431956_2432733_-\|glucosaminidase-domain-containing-protein	gnl\|CDD\|226656	COG4193, LytD, Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism].	6.77563e-118
NC_017333.1\|WP_000988992.1\|2424831_2426232_-\|Na+/H+-antiporter-NhaC	gnl\|CDD\|188097	TIGR00931, Uncharacterized_Na+/H+_antiporter_HI_1107, Na+/H+ antiporter NhaC. A single member of the NhaC family, a protein from Bacillus firmus, has been functionally characterized.It is involved in pH homeostasis and sodium extrusion. Members of the NhaC family are found in both Gram-negative bacteria and Gram-positive bacteria. Intriguingly, archaeal homolog ArcD (just outside boundaries of family) has been identified as an arginine/ornithine antiporter. [Transport and binding proteins, Cations and iron carrying compounds].	9.1792e-115

>NC_017333.1|WP_000684154.1|2430223_2431348_-|FAD-dependent-monooxygenase
MKIAIIGAGIGGLTAAALLQEQGHTIKVFEKNESVKEIGAGIGIGDNVLKKLGNHDLAKGIKNAGQILSTMTVLDDKDRPLTTVKLKSNTLNVTLPRQTLIDIIKSYVKDDAIFTNHEVTHIDNETDKVTIHFAEQESEAFDLCIGADGIHSKVRQSVNADSKVLYQGYTCFRGLIDDIDLKHPDCAKEYWGRKGRVGIVPLLNNQAYWFITINSKENNHKYSSFGKPHLQAYFNHYPNEVREILDKQSETGILLHNIYDLKPLKSFVYGRTILLGDAAHATTPNMGQGAGQAMEDAIVLVNCFNAYDFEKALQRYDKIRVKHTAKVIKRSRKIGKIAQYRSRLVVAVRNRIMKMMPNALAAGQTKFLYKSKEK
>NC_017333.1|WP_000417008.1|2429178_2430132_+|2-hydroxyacid-dehydrogenase
MEKVYVAGAIPEVGLKLLQEHFEVEMYEGKGLVDKDTLIKGVKDATALISLLSTNVDKDVIDAGKDLKIIANYGAGFNNIDIEYAREKSIDVTNTPKASTNATADLTIGLVLAVARRIVEGDQLSRTTGFDGWAPLFFRGREVSGKTIGIIGLGEIGSAVARRARAFDMDVLYTGPNRKEEKEREIGAKYVDLDTLLKNADFITINAAYNPKMHHLIDTEQFKMMKSTAYLINASRGPIVHEQALVQALKNNEIEGAALDVYEFEPDITDDLKSLNNVVLTPHIGNATFEARDMMSKIVANAAISAVQGEKPQFVVN
>NC_017333.1|WP_000737699.1|2428315_2428816_+|CHAP-domain-containing-protein
MKKLVTATTLTAGIGTALVGHAQHADAAENYTNYNNYNYNTTQTTTTTTTTTTTSSISHSGNLYTAGQCTWYVYDKVGGEIGSTWGNANNWAAAAQGAGFTVNHTPSKGAILQSSEGPFGHVAYVESVNSDGSVTISEMNYSGGPFSVSSRTISASEAGNYNYIHI
>NC_017333.1|WP_000206106.1|2427656_2428079_+|DUF4870-domain-containing-protein
MTTEMNDVTNHQPNRKSNDENIMAMLIYLLSLFTSIIGPLIIWLLKKDESKLVDRAGKNYLNYTISYIIWSIVLVVITFIGVFLIATDIDFIIIIGFIITFIGILSIFAFSILSFVFTIIACVKYYNGQEYVIPLTIRFI
>NC_017333.1|WP_000684571.1|2426326_2427409_-|NAD/NADP-octopine/nopaline-dehydrogenase-family-protein
MKIAIVGSGNGAVTAAVDMVSKGHDVKLYCRNQSISKFQNAIEKGGFDFNNEGEERFVKFTDISDDMEYVLKDAEIVQVIIPSSYIEYYADVMAEHVTDNQLIFFNMAAAMGSIRFMNVLEDRHIETKPQLAEANTLTYGTRVDFENAAVDLSLNVRRIFFSTYDRSCLNDCYDKVSSIYDHLVKEESLIKTNLENGNPEVHPGPTLLNVGRIDYAGEFALYKEGITKHTVRLLHAIELERLNLGRRLGFELSTAKESRIERGYLERDKEDEPLNRLFNTSPVFSQIPGPNHVESRYLTEDIAYGLVLWSSLGRVIDVPTPNIDAVIVIASTILERDFFEEGLTVESIGLDKLDLEKYLK
>NC_017333.1|WP_000988992.1|2424831_2426232_-|Na+/H+-antiporter-NhaC
MMTRKPTFLESISTMIVMVIVVVTGFVFFDIPIQVLLIIASAYAAWIAKRVGLTWQDLEKGIAERLNTAMPAILIILAVGIIVGSWMFSGTVPALIYYGLDLLNPSYFLISAFFISAVTSVATGTAWGSASTAGIALISIGNQLSISPGMAAGAIIAGAVFGDKMSPLSDTTNLAALVTKVNIFKHIRSMMWTTIPASIIGLLVWFIAGFQFKGHSNDKQIQTLLSELAHIYQINIWVWVPLIVIIVCLLFKMATVPAMLISSFSAIIVGTFNHHFKMTDGFKAIFSGFNDSMIHQSHISSSVKSLLEQGGMMSMTQILVTIFCGYAFAGIVEKAGCLEVLLTTISKGIHSVGSLICITVICCIALVFAAGVASIVIIMVGVLMKDLFEKYQVSRFVLSRTLEDSSTMVLPLIPWGTSGIYYTNQLHVSVGEFFIWTVPCYLCAIIAIIYGFTGIGIKKSSNSRLT
>NC_017333.1|WP_001826088.1|2424463_2424658_-|hypothetical-protein
MTKLIENLKASIFVSTLTKNLSMYSRFDAPKFGCVNGCMLFILYYRVNRIGENRSFEISTNPIF
>NC_017333.1|WP_000717395.1|2423585_2424395_+|CHAP-domain-containing-protein
MKKIATATIATAGFATIAIASGNQAHASEQDNYGYNPNDPTSYSYTYTIDAQGNYHYTWKGNWHPSQLNQDNGYYSYYYYNGYNNYSYNNYNNGYSYNNYSRYNNYSNNNQSYNYNNYNSYNTNSYRTGGLGASYSTSSNNVQVTTTMAPSSNGRSISSGYTSGRNLYTSGQCTYYVFDRVGGKIGSTWGNASNWANAAARAGYTVNNTPKAGAIMQTTQGAYGHVAYVESVNSNGSVRVSEMNYGYGPGVVTSRTISASQAAGYNFIH
>NC_017333.1|WP_000032840.1|2420252_2420996_-|transcriptional-regulator
MSKFKVKRLTAHILMLKVINDMLKYSFHLTLTQVKLLNLLVKYDNSDSNSASIDRLLKMKEIQSKMALLQMLSYLNNHQWLLKARDQRDQRKLTISINKMHIDKIEYMNNELSDYIERYFGQYTFDFSCDYVSYLLSSQELLLNLKCYLNMCQLSLEELYVLGILNLHKGQLTVKELQGEFHHPIFAVSPILKCLILKGLVKKERCELDERRVIVTIKREKFSKVTMLIQACYNYLEKGIQVKLNNK
>NC_017333.1|WP_000599591.1|2419862_2420189_-|PH-domain-containing-protein
MILDNVNPNDLFPTEKKGPSVLGIIEYQVQGKNEFEGAFIATNERLIMNVDMNGQFYYRSISYNEIEKIDYDGQTIMFKFNIGNVPMHDIKSDNVEMFVEYVKQHMIV
>NC_017333.1|WP_000739235.1|2431956_2432733_-|glucosaminidase-domain-containing-protein
MKKNFKLRISTLLLIVILVVFSVLLIVNETKLFKNDVNYSFDEAVSMQQGKGIVQTKEEDGKFVEANNNEIAKAMTISHKDNDMKYMDITEKVPMSESEVNQLLKGKGILENRGKVFLEAQEKYEVNVIYLVSHALVETGNGKSELAKGIKDGKKRYYNFFGIGAFDSSAVRSGKSYAEKEQWTSPDKAILGGAKFIRNEYFENNQLNLYQMRWNPENPAQHQYASDIRWADKIAKLMDKSYKQFGIKKDDIRQTYYK
>NC_017333.1|WP_000921246.1|2432754_2432988_-|hypothetical-protein
MLKTSAVISNTLLVIGLVCLFMMKLVLAITFFAVSLSISLVVFNMMFRDRTTMKVIVNASFLIVILAIVVAYFLLSK
>NC_017333.1|WP_000840813.1|2433282_2433756_-|DUF1641-domain-containing-protein
MAERISSKIRRLEKSEEQIKLESLNEVTEAIAANKDSILKAIKLIKVLDDAKILDALNGAVRGRQVIINKFAVELNKDIYTGLLSNMASMVFLLGELNVSDLSDFLNKVNKGLHVANQASPNAKTSVRSLFGVLKDDDMNRSLTYMLNMLKGMSRED
>NC_017333.1|WP_001155267.1|2433755_2436710_-|formate-dehydrogenase-subunit-alpha
MQEHLVVTLDGKDYLVEPGTNLLEFIKSQDTFVPSICYNESMGPIQTCDTCTVEIDGKIERSCSTVIDRPMTVNTVNNDVKDAQKEALDRILEKHMLYCTVCDYNNGDCEIHNTMDAWGLQHQTYEYKEKPYEKDYGPFYRYDPNQCILCGRCVEACQDIEVNETIRIDWDREHPRVIWDNDVPINESSCVSCGQCATVCPCNAMMEVNMEGNAGYMTDTEPGSLAAMIDLTKKAEPGYGPLFAISDSEAEMRKERIKKTKTVCTYCGVGCSFEVWTKDREILKVQPSHDSPANKIATCVKGKFSWGHINSDQRLTKPLVRKNGEFHEVEWDEALNVIADNFTSIKEKHGPDALSFISSSKATNEESYLMQKLARQVIGTNNVDNCSRYCQAPATKGLFRTVGHGGDSGSIEDLEKAAMSVLIGTNTAEAHPVIASRMKRAQKLFGQKIHVFDIRKHEMAERADRFYQPKPGTDLAWLSAVTKYIIDHDLHDKAFIEEWVEDFDEYYKSLETFTMAFAEEATGIPEAELIKFAEECAKAESVVICWAMGITQQDIGSDSSTAISNLLLVTGNYRRPGTGAYPLRGHNNVQGCSDMGSMPDKITGYQSIEADDIRAKFEKEYGVKLNPKAGKDNHEMVEGIHDGQIHSLYLYGEDTGIVDSNINFVQAAFEKLDFMVVQDEFLTFTATFADVVLPASPSLEKDGTFTNTERRIQRLYQALKPLGESKPDWKIFQAIANKLGFDWNYKHPSEIMDEIARLTPLYAGVSYERLEGFNSLQWPVHPDGTDEPILYLEGFNFDNGKAKLFPLSFDNYFKQDEVYDIHVNNGRLLEHFHEGNMTYQTPMLKYKVPRAFVEISPELAEDRGIHEGAEVKLISETGEAVLQVHVTDRVKGKEIYIPLNNDAMENGDLGAINLLTNSDVDQYTDTPSYKRTSCRLEVITKRGKSPLNPNNFRVNKKRHPQYSVQVQKKWERPDYVFPGNQVDK
>NC_017333.1|WP_000831053.1|2437311_2438259_-|LCP-family-protein
MKRSSKSKMSLPKKIFLWVFGILVILAIVAVVYVAAKIFITGNKIHNPLDRNHSELRDKKVSLNDGDPFTIALFGVDSDADRKKKGGGERSDSIMILSINPKTKKTEIVSIPRDTRAEIVGRDTTEKIAHAYAYGGPNMAVKSLEKLMNVPIDHYATIDMDGLHNMIDSIGGVDVVSNDTFTVDGVRFTKGQQTHVNGDQALKFIRSRKEEGAGGDFGRQQRQQIVLEAMANKIASPSSITHFNSLMNEIQNNVKTDLTLGDLNTIRSNYKDANDTINKHQLSGQGGIQSDGLYYFIPSEQSKAESTKLLKDNLE
>NC_017333.1|WP_000130460.1|2438391_2439189_-|inositol-monophosphatase
MTDKTLQQIDKLICSWLKQIDNVIPQLIMEMTTETKRHRFDLVTNVDKQIQQQFQQFLATHFQEHQLLAEEKSNEMITNEINHLWIMDPIDGTANLVKQQEDYCIILAYFYEGKPMLSYVYDYPHKKLYKAIRGEGAFCNGIKMEEPPSLKLEDAIISFNAQVMNLDTVQDLFDASFSYRLVGACGLDSMRVAKGQFGAHINTNPKPWDIAAQFLFAELLNLKMTTLDGKAIDHLKGAPFIISNKACHETVLKILNANGGYQKYR
>NC_017333.1|WP_001030125.1|2439573_2440266_+|YafY-family-transcriptional-regulator
MNKAERQNLIITAIQQNKKMTALELAKYCNVSKRTILRDIDDLENQGVKIYAHYGKNGGYQIQQAQSKIALNLSETQLSALFLVLNESQSYSTLPYKSEINAIIKQCLSLPQTRLRKLLKRMDFYIKFDDTQHMTLPMLFSDILIYCTERNVMLVDHRVDDNIKAENVIFIGLLCKHGHWHAVIYDIAQDKTAELEIENIIDISYSFGKTIQTRDISIDNYHQFLNPIDS
>NC_017333.1|WP_000426692.1|2440290_2441028_-|CPBP-family-intramembrane-metalloprotease-SdpB
MENEKKKYTFKDIAWRDLFIIPIIGVLSFALTIAAYIVPILFGYYEIDSNLIFVGTITQALAYTIGIGAFYLFHLKVMPSRLRAGFAYIKKYWLRLSITYIIALILIYTYEYMTQFLPKHLQYSETANELELNKMFEVPVFLPVAFLLIVIVGPIVEEIVFRHILIGELGKKFNFIAMSIVSVFLFAFIHVTDAKSPFEFGPYLILSIILVFTYIKSGRNLGSTIALHIANNFVSFVISVISIYA
>NC_017333.1|WP_000606724.1|2441076_2441406_+|hypothetical-protein
MINETKYMRQQITNLIQIIDTIKYNTLMTDWNIQTHIYKFNQIVTNELNKFKGFETSYIINENQVFYYEIITLLNKRPLRQVDYGNKIQYLNFYHTELSNALFAIKFAH
>NC_017333.1|WP_000073196.1|2441850_2442723_+|MurR/RpiR-family-transcriptional-regulator
MSNVLTEIDSQYPYMTKNEKKIAKFILNSPQKVIKMRSQDLASLLDISTSSVIRFSKKITDGGFHDLKINISKYVPKASSIYNVELMNNESTESLRTKLHTRTTRALNHANNELNDKTIDQICHCLKRSETIFIYGFGASFVVATDLYQKLSRIGLNIQLVQETHIFATLLATHNSNDSVILITNNGTQSEMQSMVKVIDDYHIPIITITSTRDNPVAQASNIVLTYGKTDENEMHMGATTSLFAQMFTIDILYYRYVALNYHASLDYITQSKMALDNYRKHLSNINFKH

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Crispr_ID: NC_017333_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_11

2548135-2548229

Orphan

Consensus_repeat	Method
TTCTTCAAATTTATTTGTTAGAAAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017333_11

>merge|NC_017333|11|2548135-2548229|CRISPRCasFinder
TTCTTCAAATTTATTTGTTAGAAAGGCTTATGCAGTTGACGTTTTACGTCCAACTGCGTTCCTTCGTCTTCTTCAAATTTATTTGTTAGAAAGGC

>NC_017333|11|11|2548135-2548229|CRISPRCasFinder
TTCTTCAAATTTATTTGTTAGAAAGGC	TTATGCAGTTGACGTTTTACGTCCAACTGCGTTCCTTCGTC
TTCTTCAAATTTATTTGTTAGAAAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_000038955.1\|2544243_2545683_-\|multidrug-efflux-MFS-transporter-MdeA	unknown	unknown	gnl\|CDD\|129794
NC_017333.1\|WP_001056917.1\|2552913_2553891_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	unknown	unknown	gnl\|CDD\|273388
NC_017333.1\|WP_000916697.1\|2551964_2552912_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	unknown	unknown	gnl\|CDD\|369625
NC_017333.1\|WP_001012240.1\|2540568_2541819_+\|FemA/FemB-family-glycyltransferase-FmhA	unknown	unknown	gnl\|CDD\|367067
NC_017333.1\|WP_001046647.1\|2556216_2557224_-\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|235755
NC_017333.1\|WP_000594523.1\|2550467_2551397_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	unknown	unknown	gnl\|CDD\|369625
NC_017333.1\|WP_000762708.1\|2545856_2545961_+\|putative-metal-homeostasis-protein	unknown	unknown	unknown
NC_017333.1\|WP_000825936.1\|2543343_2544123_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270429
NC_017333.1\|WP_000971556.1\|2555123_2556239_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223234
NC_017333.1\|WP_000479573.1\|2542643_2543363_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_017333.1\|WP_000162807.1\|2539333_2539933_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|224565
NC_017333.1\|WP_001125208.1\|2546114_2546801_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184518
NC_017333.1\|WP_000019127.1\|2547126_2547993_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NC_017333.1\|WP_000819845.1\|2539951_2540314_-\|DUF4467-domain-containing-protein	unknown	unknown	gnl\|CDD\|291399
NC_017333.1\|WP_001807892.1\|2548407_2548527_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_001110056.1\|2557225_2558584_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
NC_017333.1\|WP_000286872.1\|2554420_2555113_-\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|224342
NC_017333.1\|WP_000200954.1\|2553942_2554410_-\|QueT-transporter-family-protein	unknown	unknown	gnl\|CDD\|377623
NC_017333.1\|WP_000792574.1\|2548621_2549932_+\|B-domain-containing-protein	unknown	unknown	gnl\|CDD\|288473
NC_017333.1\|WP_000615466.1\|2541915_2542647_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_000038955.1\|2544243_2545683_-\|multidrug-efflux-MFS-transporter-MdeA	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	7.17835e-92
NC_017333.1\|WP_001046647.1\|2556216_2557224_-\|biotin-synthase-BioB	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
NC_017333.1\|WP_000916697.1\|2551964_2552912_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	1.12563e-91
NC_017333.1\|WP_001012240.1\|2540568_2541819_+\|FemA/FemB-family-glycyltransferase-FmhA	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	0
NC_017333.1\|WP_000594523.1\|2550467_2551397_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	3.62723e-97
NC_017333.1\|WP_000286872.1\|2554420_2555113_-\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|224342	COG1424, BioW, Pimeloyl-CoA synthetase [Coenzyme metabolism].	8.32691e-130
NC_017333.1\|WP_000825936.1\|2543343_2544123_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.4238e-99
NC_017333.1\|WP_000971556.1\|2555123_2556239_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	7.0088e-136
NC_017333.1\|WP_001056917.1\|2552913_2553891_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	2.43039e-128
NC_017333.1\|WP_000162807.1\|2539333_2539933_-\|DsbA-family-protein	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	3.11803e-30
NC_017333.1\|WP_001125208.1\|2546114_2546801_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184518	PRK14119, gpmA, phosphoglyceromutase; Provisional.	3.52864e-167
NC_017333.1\|WP_000019127.1\|2547126_2547993_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	2.54055e-90
NC_017333.1\|WP_000819845.1\|2539951_2540314_-\|DUF4467-domain-containing-protein	gnl\|CDD\|291399	pfam14729, DUF4467, Domain of unknown function with cystatin-like fold (DUF4467). Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan.	4.12726e-31
NC_017333.1\|WP_000479573.1\|2542643_2543363_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	8.38308e-78
NC_017333.1\|WP_001110056.1\|2557225_2558584_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
NC_017333.1\|WP_000200954.1\|2553942_2554410_-\|QueT-transporter-family-protein	gnl\|CDD\|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	0.00118414
NC_017333.1\|WP_000792574.1\|2548621_2549932_+\|B-domain-containing-protein	gnl\|CDD\|288473	pfam11621, Sbi-IV, C3 binding domain 4 of IgG-bind protein SBI. This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.	1.53315e-25
NC_017333.1\|WP_000615466.1\|2541915_2542647_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	8.01718e-147

>NC_017333.1|WP_000019127.1|2547126_2547993_-|cation-transporter
MSHNENLKLAQRGAYLSLIVYIILSIVKYVTGFVFNSAAVRADALNNMTDIIVSLAVIIGLKISIKPADRNHPYGHLKSENISSLLVSFVIMFVGIQVVIQNAPRLFKEDDVVPNAITIIVSLISGLVMLIVFAVNQRLAKRTKSSSLNSAAKDNLSDSLVSIGTAIGLIFTQIGFPIVDIILATLLGLLIVYTGFGIFKEAIFMLSDGFNETELEAYRNDILEVDEVQEVKSIKGRYHGSSVFIDVTIVVDANLSLVEAHQICDNVEHHLHKKGISSVYVHPEPDHL
>NC_017333.1|WP_001125208.1|2546114_2546801_-|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase
MPKLILCRHGQSEWNAKNLFTGWEDVNLSEQGINEATRAGEKVRENNIAIDVAFTSLLTRALDTTHYILTESKQQWIPVYKSWRLNERHYGGLQGLNKDDARKEFGEEQVHIWRRSYDVKPPAETEEQREAYLADRRYNHLDKRMMPYSESLKDTLVRVIPFWTDHISQYLLDGQTVLVSAHGNSIRALIKYLEDVSDEDIINYEIKTGAPLVYELTDDLEVIDKYYL
>NC_017333.1|WP_000762708.1|2545856_2545961_+|putative-metal-homeostasis-protein
MKLDLQTARRNLNSPNIKTRKRALKIIKQHKRAK
>NC_017333.1|WP_000038955.1|2544243_2545683_-|multidrug-efflux-MFS-transporter-MdeA
MSKKQKLTMIITMLMGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVIPLSALVIQRYTTRQVFLVGISIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTTILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGFKTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGIVLVALFVLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGLTLLPGAIVMAFMSMTSGALYEKFGPRKLALVGMAIVVITTAYFVVMDEQTSTIMLATVYAIRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFSPTMSDYNGMNKIEMMNQIKIDTMLHGYHAGFLFALLITVISFFCSFMLQGKKKEVDSHQ
>NC_017333.1|WP_000825936.1|2543343_2544123_-|transporter-substrate-binding-domain-containing-protein
MKRLLFVVIAFVFILAACGNNSSKDKEASKDSKTINVGTEGTYAPFSFHDKDGKLTGYDIDVIKAVAKAEGLKLKFNETSWDSMFAGLDAGRFDVIANQVGINPDREKKYKFSKPYTFSSAVLVIRENEKDIKDFDDVKGKKLAQTFTSNYGKLAKDKGADITKVDGFNQSMDLLLSKRVDGTFNDSLSYLDYKKQKPNAKIKAIKGNAEQSKSAFAFSKKVDDETVQKFNDGLKKIEENGELAKIGKKWFGQDVSKSK
>NC_017333.1|WP_000479573.1|2542643_2543363_-|amino-acid-ABC-transporter-permease
MFLNLNSEQLHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKVLRSIARVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYRQTIQRIILPQAIRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIISIIQGIYESYIERGYRS
>NC_017333.1|WP_000615466.1|2541915_2542647_-|amino-acid-ABC-transporter-ATP-binding-protein
MIQLNNIHKSFNDVEVIKGIDLSVGKGEVVTLIGRSGSGKTTLLRMINALEIPTEGTVFVNGKTYTSKDKKSQIEVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKLKKAEAREKSLELLEKVGLTHVKDQRPHALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLKVIKDLANEGMTMVIVTHEMRFAREVSNNIVFIHEGEIGEQGAPEEIFNNPKTEELKRFLNVINEE
>NC_017333.1|WP_001012240.1|2540568_2541819_+|FemA/FemB-family-glycyltransferase-FmhA
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHRVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKQNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDTLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLAYIDLNEYLKTLQLKQQQLTAELSGVEEVLEESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHINRYNFYGITGDFSESAEDYGVQQFKKGFNAHVEEYIGDFIKPIKPMLYKLQTYLKHKRR
>NC_017333.1|WP_000819845.1|2539951_2540314_-|DUF4467-domain-containing-protein
MKRFVATVLLLLVFISGCGNDKYVKEIDEAVKIQNQKQEQLAKKGNGDRVDHFERKDANIYVYDKDKIIILAYKPLSNDDEVHYYAYDFSDKRVSYKQGFDSRRYYQQHDADYHEENMTN
>NC_017333.1|WP_000162807.1|2539333_2539933_-|DsbA-family-protein
MTKKLLTLFIVSMLILTACGKKESATTSSKNGKPLVVIYGDYKCPYCKELDEKVMPKLRKNYIDNHKVEYQFVNLAFLGKDSIVGSRASHAVLMYAPKSFLDFQKQLFAAQKDENKEWLTKELLDKHIKQLHLDKETENKIIKDYKTKDSKSWKAAEKDKKIAKGNHIKTTPTAFINGEKVEDPYDYESYEKLLKDKIK
>NC_017333.1|WP_001807892.1|2548407_2548527_-|hypothetical-protein
MLTNRLTSVNYVKKRLIQNIQRILSKEVLYEEMQYFANK
>NC_017333.1|WP_000792574.1|2548621_2549932_+|B-domain-containing-protein
MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAITKLQKNDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKAESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYTDKYFKYKGTIDKTVLSVFGNGYKSYIQPLKVEDQKNYVSKSYAQVRNYVTETLNTGKVLYAFYQNPKVVKAAITTAETASSIKNTLSNLLSFWK
>NC_017333.1|WP_000594523.1|2550467_2551397_+|bi-component-gamma-hemolysin-HlgAB-subunit-A
MIKNKILTATLAVGLIAPLANPFTEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHEKGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
>NC_017333.1|WP_000916697.1|2551964_2552912_+|bi-component-gamma-hemolysin-HlgCB-subunit-C
MLKNKILATTLSVSLLAPLANPLLENAKAANDTEDIGKGNDVEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKNTNHIKSMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQTLGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPSFIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFKNRNYTVKYEVNWKTHEIKVKGQN
>NC_017333.1|WP_001056917.1|2552913_2553891_+|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B
MNMNKLVKSSVATSMALLLLSNTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKAAGNINSGYERPNPKDYDFSKIYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
>NC_017333.1|WP_000200954.1|2553942_2554410_-|QueT-transporter-family-protein
MTSKDITQISVIAAILTILAVLKIPSIIPGLDFQLSAPAALLILAFFGIKKYFLGGLLSSVLLLIFGVFNPINVIISIIFRVIAIAVVYLLKINVLSLVLASVLGSLVSRLLLSIILNLPVWVVLLNAIPGVIFTLIVAIPLYLTLRKRMAVLLR
>NC_017333.1|WP_000286872.1|2554420_2555113_-|6-carboxyhexanoate--CoA-ligase
MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIDDDKANLQHLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFASAKIGYHRLFDIKPVNTRYGGRIIFVDDRIDLNHYISFLESTPKQVIYETV
>NC_017333.1|WP_000971556.1|2555123_2556239_-|pyridoxal-phosphate-dependent-aminotransferase-family-protein
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDQVDFESFMRKYSYHLSSSRLISGSSTVYEEIESMLADWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAEYPNQNIPKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSNDVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHAEQDIDRLFEILHQED
>NC_017333.1|WP_001046647.1|2556216_2557224_-|biotin-synthase-BioB
MNLAKRILQGEQLTKETVLKIYEDTNIDTLDLLNEAYILRKHYFGKKVKLNMILNAKSGICPENCGYCGQSRDIKQKQRYALIPEEQIIDGAKVAHDNHIGTYCIVMSGRGPSDKEVDHISNTVRTIKSQHPQLKICACLGLTNDEQAKKLKSAGVDRYNHNINTSENYHDNVVTTHSYKDRTDTIELMKANNISPCSGVICGMGESNQDIVDMAFALKEMDADSIPINFLHPIKGTKFGSMDDLTPMKCLRIVALFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQPNQLDYDMINDLGFEIDYGTCENKENKNDVSRAN
>NC_017333.1|WP_001110056.1|2557225_2558584_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MNYTQQLKQKDSEYVWHPFTQMGVYSKEEAIIIEKGKGSYLYDTNGNKYLDGYASLWVNVHGHNNKYLNKVIKKQLNKIAHSTLLGLSNIPSIELAEKLIEITPSNLRKVFYSDTGSASVEIAIKMAYQYWKNIDREKYAKKNKFITLNHGYHGDTIGAVSVGGIKTFHKIFKDLIFENIQVESPSFYRSNYDTENEMMAAILTNIEQILIERNDEIAGFILEPLIQGATGLFVHPKGFLKEVEKLCKKYDVLLICDEVAVGFGRTGKMFACNHEDVQPDIMCLGKAITGGYLPLAATLTSQKIYNAFLSDSHGVNTFFHGHTYTGNQIVCTVALENIRLYEKRKLLSHIETTSSTLEKQLHALKRHRNVGDVRGRGLMFGVELVTDKDSKTPLEIEKVERIVRNCKENGLMIRNLENVITFVPVLSMSNKEVKTMVRIFKKAVHNILDRKC

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Crispr_ID: NC_017333_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_12

2607860-2607954

Orphan

Consensus_repeat	Method
AGGCTCTTATGCAGTTGGTGCGAAGCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017333_12

>merge|NC_017333|12|2607860-2607954|CRISPRCasFinder
AGGCTCTTATGCAGTTGGTGCGAAGCAAGCAACTGTATTCCTCTAAAACTGTAATTTTAATTACTAGAGGCTCTTATGCAGTTGTTGCGAAGCAA

>NC_017333|12|12|2607860-2607954|CRISPRCasFinder
AGGCTCTTATGCAGTTGGTGCGAAGCAA	GCAACTGTATTCCTCTAAAACTGTAATTTTAATTACTAG
AGGCTCTTATGCAGTTGTTGCGAAGCAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_001058850.1\|2606023_2606842_-\|D-histidine-(S)-2-aminobutanoyltransferase-CntL	unknown	unknown	gnl\|CDD\|176222
NC_017333.1\|WP_000072469.1\|2597445_2598192_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000910577.1\|2608622_2608985_-\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000505991.1\|2615797_2616112_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000173877.1\|2600362_2601178_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NC_017333.1\|WP_001081687.1\|2606852_2607674_-\|histidine-racemase-CntK	unknown	unknown	gnl\|CDD\|223331
NC_017333.1\|WP_000040594.1\|2604729_2606031_-\|staphylopine-dehydrogenase-CntM	unknown	unknown	gnl\|CDD\|226839
NC_017333.1\|WP_000037506.1\|2613268_2613679_-\|DUF1433-domain-containing-protein	unknown	unknown	gnl\|CDD\|284628
NC_017333.1\|WP_000472235.1\|2602040_2602976_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_017333.1\|WP_000675405.1\|2598415_2599609_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NC_017333.1\|WP_000905462.1\|2614133_2614517_-\|DUF1433-domain-containing-protein	unknown	unknown	gnl\|CDD\|284628
NC_017333.1\|WP_001124998.1\|2617988_2618408_-\|DUF1433-domain-containing-protein	unknown	unknown	gnl\|CDD\|284628
NC_017333.1\|WP_001084931.1\|2614583_2615792_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153341
NC_017333.1\|WP_001229077.1\|2602988_2604587_-\|staphylopine-dependent-metal-ABC-transporter-substrate-binding-protein-CntA	unknown	unknown	gnl\|CDD\|274072
NC_017333.1\|WP_000584764.1\|2601174_2602044_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_017333.1\|WP_000202032.1\|2610299_2611838_+\|AbgT-family-transporter	unknown	unknown	gnl\|CDD\|367668
NC_017333.1\|WP_000590515.1\|2599620_2600370_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224049
NC_017333.1\|WP_000824954.1\|2609247_2610066_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181491
NC_017333.1\|WP_001146763.1\|2611949_2612372_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NC_017333.1\|WP_001807941.1\|2612843_2613242_-\|DUF1433-domain-containing-protein	unknown	unknown	gnl\|CDD\|284628

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_001058850.1\|2606023_2606842_-\|D-histidine-(S)-2-aminobutanoyltransferase-CntL	gnl\|CDD\|176222	cd08261, Zn_ADH7, Alcohol dehydrogenases of the MDR family. This group contains members identified as related to zinc-dependent alcohol dehydrogenase and other members of the MDR family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group includes various activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0.000104575
NC_017333.1\|WP_000472235.1\|2602040_2602976_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.46808e-99
NC_017333.1\|WP_001146763.1\|2611949_2612372_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	2.83513e-29
NC_017333.1\|WP_000173877.1\|2600362_2601178_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.80608e-117
NC_017333.1\|WP_001081687.1\|2606852_2607674_-\|histidine-racemase-CntK	gnl\|CDD\|223331	COG0253, DapF, Diaminopimelate epimerase [Amino acid transport and metabolism].	2.70571e-73
NC_017333.1\|WP_000040594.1\|2604729_2606031_-\|staphylopine-dehydrogenase-CntM	gnl\|CDD\|226839	COG4408, COG4408, Uncharacterized protein conserved in bacteria [Function unknown].	0
NC_017333.1\|WP_000037506.1\|2613268_2613679_-\|DUF1433-domain-containing-protein	gnl\|CDD\|284628	pfam07252, DUF1433, Protein of unknown function (DUF1433). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	5.68109e-39
NC_017333.1\|WP_000675405.1\|2598415_2599609_-\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.44638e-79
NC_017333.1\|WP_000905462.1\|2614133_2614517_-\|DUF1433-domain-containing-protein	gnl\|CDD\|284628	pfam07252, DUF1433, Protein of unknown function (DUF1433). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	1.96173e-37
NC_017333.1\|WP_001124998.1\|2617988_2618408_-\|DUF1433-domain-containing-protein	gnl\|CDD\|284628	pfam07252, DUF1433, Protein of unknown function (DUF1433). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	1.11006e-27
NC_017333.1\|WP_001229077.1\|2602988_2604587_-\|staphylopine-dependent-metal-ABC-transporter-substrate-binding-protein-CntA	gnl\|CDD\|274072	TIGR02294, Nickel-binding_periplasmic_protein, nickel ABC transporter, nickel/metallophore periplasmic binding protein. Members of this family are periplasmic nickel-binding proteins of nickel ABC transporters. Most appear to be lipoproteins. This protein was previously (circa 2003) thought to mediate binding to nickel through water molecules, but is now thought to involve a chelating organic molecule, perhaps butane-1,2,4-tricarboxylate, acting as a metallophore. [Transport and binding proteins, Cations and iron carrying compounds].	0
NC_017333.1\|WP_000584764.1\|2601174_2602044_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.45335e-84
NC_017333.1\|WP_000202032.1\|2610299_2611838_+\|AbgT-family-transporter	gnl\|CDD\|367668	pfam03806, ABG_transport, AbgT putative transporter family.	0
NC_017333.1\|WP_000590515.1\|2599620_2600370_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224049	COG1124, DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.955e-107
NC_017333.1\|WP_000824954.1\|2609247_2610066_-\|SDR-family-oxidoreductase	gnl\|CDD\|181491	PRK08589, PRK08589, SDR family oxidoreductase.	0
NC_017333.1\|WP_001084931.1\|2614583_2615792_+\|hypothetical-protein	gnl\|CDD\|153341	cd07657, F-BAR_Fes_Fer, The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) and Fer (Fes related) tyrosine kinases. F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Fes (feline sarcoma), also called Fps (Fujinami poultry sarcoma), and Fer (Fes related) are cytoplasmic (or nonreceptor) tyrosine kinases that play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Although Fes and Fer show redundancy in their biological functions, they show differences in their expression patterns. Fer is ubiquitously expressed while Fes is expressed predominantly in myeloid and endothelial cells. Fes and Fer contain an N-terminal F-BAR domain, an SH2 domain, and a C-terminal catalytic kinase domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules. The F-BAR domain of Fes is critical in its role in microtubule nucleation and bundling.	0.00836241
NC_017333.1\|WP_001807941.1\|2612843_2613242_-\|DUF1433-domain-containing-protein	gnl\|CDD\|284628	pfam07252, DUF1433, Protein of unknown function (DUF1433). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	3.40871e-34

>NC_017333.1|WP_001081687.1|2606852_2607674_-|histidine-racemase-CntK
MNRQVIEFSKYNPSGNMTILVHSKHDASEYASIANQLMAATHVCCEQVGFIESTQNDDGNDFHLVMSGNEFCGNATMSYIHHLQESHLLKDQQFKVKVSGCSDLVQCAIHDCQYYEVQMPQAHRVVPTTINMGNHSWKAIEIIYETYVHYVIPVKQVTTEIQHLVETYVRKQQWNHKYKTVGMMLFDEQRQFLQPLIYIPEIQSLIWENSCGSGTASIGVFNNYQRNDACKDFTVHQPGGSILVTSKRCHQLGYQTSIKGQVTTVATGKAYIE
>NC_017333.1|WP_001058850.1|2606023_2606842_-|D-histidine-(S)-2-aminobutanoyltransferase-CntL
MNNFNNEIKLILQQYLEKFEAHYERVLQDDQYIEALETLMDDYSEFILNPIYEQQFNAWRDVEEKAQLINSLQYITAQCVKQVEVIRARRLLDGQASTTGYFDNIEHCIDEEFGQCSIASNDKLLLVGSGAYPMTLIQVAKETGASVIGIDIDPQAVDLGRRIVNVLAPNEDITITDQKVSELKDIKDVTHIIFSSTIPLKYSILEELYDLTNENVVVAMRFGDGIKAIFNYPSQETAEDKWQCVNKHMRPQQIFDIALYKKAAIKVGITDV
>NC_017333.1|WP_000040594.1|2604729_2606031_-|staphylopine-dehydrogenase-CntM
MSKLLMIGTGPVAIQLANICYLKSDYEIDMVGRASTSEKSKRLYQAYKKEKQFEVKIQNEAHQHLEGKFEINRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISPTFGSQMIVEQFMSKFSQDIEVISFSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTYSNSTMCQRISVLAEQLKIQLEVVESPLHAETRNSSLYVHPPLFMNDFSLKAIFEGTDVPVYVYKLFPEGPITMTLIREMRLMWKEMMAILQAFRVPSVNLLQFMVKENYPVRPETLDEGDIEHFEILPDILQEYLLYVRYTAILIDPFSQPDENGHYFDFSAVPFKQVYKNEQDVVQIPRMPSEDYYRTAMIQHIGKMLGIKTPMIDQFLTRYEASCQAYKDMHQDQHLSSQFNTNLFEEDKALVTKFLEINRTLS
>NC_017333.1|WP_001229077.1|2602988_2604587_-|staphylopine-dependent-metal-ABC-transporter-substrate-binding-protein-CntA
MRKLTKMSAMLLASGLILTGCGGNKGLEEKKENKQLTYTTVKDIGDMNPHVYGGSMSAESMIYEPLVRNTKDGIKPLLAKKWDVSEDGKTYTFHLRDDVKFHDGTPFDADAVKKNIDAVQENKKLHSWLKISTLIDNVKVKDKYTVELNLKEAYQPALAELAMPRPYVFVSPKDFKNGTTKDGVKKFDGTGPFKLGEHKKDESADFNKNDQYWGEKSKLNKVQAKVMPAGETAFLSMKKGETNFAFTDDRGTDSLDKDSLKQLKDTGDYQVKRSQPMNTKMLVVNSGKKDNAVSDKTVRQAIGHMVNRDKIAKEILDGQEKPATQLFAKNVTDINFDMPTRKYDLKKAESLLDEAGWKKGKDSDVRQKDGKNLEMAMYYDKGSSSQKEQAEYLQAEFKKMGIKLNINGETSDKIAERRTSGDYDLMFNQTWGLLYDPQSTIAAFKAKNGYESATSGIENKDKIYNSIDDAFKIQNGKERSDAYKNILKQIDDEGIFIPISHGSMTVVAPKDLEKVSFTQSQYELPFNEMQYK
>NC_017333.1|WP_000472235.1|2602040_2602976_-|ABC-transporter-permease
MFKFILKRIALMFPLMIVVSFMTFLLTYITNENPAVTILHAQGTPNVTPELIAETNEKYGFNDPLLIQYKNWLLEAMQFNFGTSYITGDPVAERIGPAFMNTLKLTIISSVMVMITSIILGVVSALKRGKFTDRAIRSVAFFLTALPSYWIASILIIYVSVKLNILPTSGLTGPESYILPVIVITIAYAGIYFRNVRRSMVEQLNEDYVLYLRASGVKSITLMLHVLRNALQVAVSIFCMSIPMIMGGLVVIEYIFAWPGLGQLSLKAILEHDFPVIQAYVLIVAVLFIVFNTLADIINALLNPRLREGAR
>NC_017333.1|WP_000584764.1|2601174_2602044_-|ABC-transporter-permease
MIILKRLLQDKGAVIALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAGMSFQHLLGTDHLGRDILTRLIYAIRPSLLYVFVALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQYTASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPEMMFAPGIAIVIIVMAFNFLSDALQIAIDPRISSKDKLRSVKKGVMQS
>NC_017333.1|WP_000173877.1|2600362_2601178_-|ABC-transporter-ATP-binding-protein
MTLLTVKHLTITDTWTDQPLVSDVNFTLTKGETLGVIGESGSGKSITCKSIVGLNPERLRVTGDITFDGTSMLSLSESQLKKYRGKDIAMVMQQGSRAFDPSTTVGKQMFETMKVHTSMSTQEIEKTLIEYMDYLSLKDPKRILKSYPYMLSGGMLQRLMIALALALKPKLIIADEPTTALDTITQYDVLEAFIDIKKHFDCAMIFISHDLTVINKIADRVVVMKNGQLIEHGTRESVLHHPEHVYTKYLLSTKKKINDHFKHVMRGDVCD
>NC_017333.1|WP_000590515.1|2599620_2600370_-|ABC-transporter-ATP-binding-protein
MIKIKDVEKSYQSAHVFKRRRTPIVKGVSFECPIGATIAIIGESGSGKSTLSRMILGIEKPDKGCVTLNDQPMHKKKVRRHQIGAVFQDYTSSLHPFQTVREILFEVMCQCDGQPKDVMEVQAITLLEEVGLSKAYMDKYPNMLSGGEAQRVAIARAICINPKYILFDEAISSLDMSIQTQILDLLIHLRETRQLSYIFITHDIQAATYLCDQLIIFKNGKIEEQIPTSALHKSDNAYTRELIEKQLSF
>NC_017333.1|WP_000675405.1|2598415_2599609_-|MFS-transporter
MKGAMAWPFLRLYILTLMFFSANAILNVFIPLRGHDLGATNTVIGIVMGAYMLTAMVFRPWAGQIIARVGPIKVLRIILIINAIALIIYGFTGLEGYFVARVMQGVCTAFFSMSLQLGIIDALPEEHRSEGVSLYSLFSTIPNLIGPLVAVGIWNANNISLFAIVIIFIALTTTFFGYRVTFAEQEPDTSDKIEKMPFNAVTVFAQFFKNKELLNSGIIMIVASIVFGAVSTFVPLYTVSLGFANAGIFLTIQAIAVVVARFYLRKYIPSDGMWHPKYMVSVLSLLVIASFIVAFGPQVGAIIFYGSAILIGMTQAMVYPTLTSYLSFVLPKVGRNMLLGLFIACADLGISLGGALMGPISDLVGFKWMYLICGMLVIVIMIMSLLKKPTPRPANSL
>NC_017333.1|WP_000072469.1|2597445_2598192_+|hypothetical-protein
MSNTNKHYIEEYATEQSRFFKRDIGFIFLYIFLVNILPIIIVFLTFELVAVFTQQAPWGFSFPISMNISYLLAVIISLAIFRLMHEDAFIPMIRSQIVASAKYKWHILISFTLSIVLFLLLNHFDIFALNVDSFTVFDIYPLIREYGSISLIAIFSLTIILNTLICQLIFRHILIQELSRLIPLKITIVLSVILETLYYYPYINTWWEFIPALILASSATYLYLKSNRNFMVSYFYQLAVILVLHIFM
>NC_017333.1|WP_000910577.1|2608622_2608985_-|hypothetical-protein
MLKEKESFRLLYQAIREIADKIGDNQLETNSVSLLLLDFDFEHEVFDELYLAILKYLNTVSIENISHSELLNLIENTIPEDREINTFVKNKIIIGFANNYFPELQVLANEIKSDMASSLK
>NC_017333.1|WP_000824954.1|2609247_2610066_-|SDR-family-oxidoreductase
MKRLENKVAVVTGASTGIGQASAIALAQEGAYVLAVDIAEAVSKTVDKIKSNGDNAKAYTVDISDEQQVVDFVSDIKEQFGRIDVLFNNAGVDNAAGRIHEYPTDVYDKIMNVDMRGTFLMTKMMLPLMMTKGGSIVNTSSFSGQAADLYRSGYNAAKGAVINFTKSIAIEYGRDGIRANAIAPGTIETPLVDKLTGTSEDKEGKTFRENQKWMTPLGRLGKPEEVGKLVVFLASDESSFITGETIRIDGGVMAYTWPGEMLSDDSWKRTLE
>NC_017333.1|WP_000202032.1|2610299_2611838_+|AbgT-family-transporter
MTSKHQQKGSIVNRFLNSVEKIGNKLPDPSVLFFLMCVGLAIMTWVISLFNVSVKHPGTHQTIYIKNIISHDGFTMIMNDTIKNFSEFPALGLVLAVMIGIGVAEKTGYFDKLMISVVNRAPRFLILPTIILIGILGSTAGDAATIILPPLAAMLFIKIGYHPIAGLTMAYASAVGGFAANIVVGMQDALVYSFTEPATRIVSDSIKTNVAMNWYFIAASVIVLLPTILLVTTKLIIPRLGQYDDRLMHDDHEETSSHITDKEAHALKWANISFIVTIILLIITAIPEHSFLRNAKTGSLLDDAPLINGVGLIILVVFLVPGLVYGILSKEIKNTKDLGKMFGDAVGSMGTFIVIVFFAAQLLAYLKWSNLGIIAAVKGAKLLEHQNGIVLILGIIVLSAMVNMLIGSASAKWGILGPIFVPMLILIGFHPAFTQVIYRVGDSITNPITPMMPYLPLLLTYAQKYDKRMKLGALLSSLMPYSIALSIVWTVFVIIWFLLGIPVGPGGPIFVK
>NC_017333.1|WP_001146763.1|2611949_2612372_-|carboxymuconolactone-decarboxylase-family-protein
MPYNYKKQNGELMSVMSQGEKFIHQSPVNDELSALIKLLISKINGCHYCVDIHKKELKELGVTQMKIDEVLSFRHLDLFTDQEKVTLEFAEMLNSIKDFKKFEIIDRLKSFYDEEQIIDLVFVVNQINGWNRLNIISDRL
>NC_017333.1|WP_001807941.1|2612843_2613242_-|DUF1433-domain-containing-protein
MNKKHVFIIIGVILCIRIVATVIYLKVKYDEKEKQKAIYYKEQQERITLYLKHNTKEPNTIKSVHFTSLKTGPMGDAVIEGYINENKKADFVAYGSPEHNYQFGGDMIESEKLSELLKPAQELKSQKKSKKN
>NC_017333.1|WP_000037506.1|2613268_2613679_-|DUF1433-domain-containing-protein
MSKKHVFIIIGVILCICIVVTAMHLKMKYDEKEKRKAIYYKEQQARITLYLKHNTKEPNTIKSVHFTNLETSPMGSAVIEGYINENKKDNFTAYATPEHNYQFGGAMIKSEGVDKLLKPAHERKSPDDIKKELNKK
>NC_017333.1|WP_000905462.1|2614133_2614517_-|DUF1433-domain-containing-protein
MLIILIIIVCVYLKIKIDEKEKQKAIYYKEQQERITLYLKHNTEEPNTIKSVHFTSLKRGPMGDAVIEGYINENKEDDFVAYGSPEHNYQFGGDMVESERLSELLKPAHERKSPDDIKKELNKKKNH
>NC_017333.1|WP_001084931.1|2614583_2615792_+|hypothetical-protein
MNSIYDKDTTYRALAKEAYHLEPDQEKIFVPYSKEKKIEFRIVAFRQNKFNGLKMAGLSPVEKGAKLNTDELYIVYAGTDPDLLADFGSDSIEDLKVGMAKFGGGLRIPPTKKERAIYGNLNKKMIDYDDGISGISQNIMTNPISQSKESYIFTGALINKQKPKHVYGAAHSLGGGLALLNGVMYNFDGVRAFSAPNTFDLLPDEVKANYRSEKYDGKFINYLHRSDIIGNSDLFAQRIGTQIYGKDVGRFSLLNPILGHGMDTFEFKGDNVRIKMDTEEMSKIASDLKASCEFVNDAIKSYQKYMDDTKAAAKRIERKYTKKIRTGNYKHIKPSDIEDYMEELSVSGKYEFYNDTAFETVMSELNRIRKNVESFADKLKHAGEKMESRDKEIGELYKIFER
>NC_017333.1|WP_000505991.1|2615797_2616112_+|hypothetical-protein
MGFLDDLAESIEEQSDLSEFKQAMKSELQTKVEEAKAKIESIDEDIWDWQTTVNNKRDAIEEYCEGKTAEHAIERLMQDKQDIAGMRWTAEDAEKSCKVGSWFW
>NC_017333.1|WP_001124998.1|2617988_2618408_-|DUF1433-domain-containing-protein
MPKKTIFIIIGVILCISIVTGGIYLKMKHDEKEKQKEIYYKEQQERITLYLKHNTKEPNTIKTVHFTNLKTGPMGDIEIYGYINSKKDYDFIAYNSPEENYQFTGGLTGSNEVLGKLKNAENLKSPEKIKEELNNKKDH

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Crispr_ID: NC_017333_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017333_13

2635805-2635915

Orphan

Consensus_repeat	Method
GGTACTTCTGGTGTCGGTGGCGTTGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017333_13

>merge|NC_017333|13|2635805-2635915|CRISPRCasFinder
GGTACTTCTGGTGTCGGTGGCGTTGGTTCGCCTGGCTCACTCGGCACTTCTGGTGTCGGTGGTGTTGGTGTTTCCGGCTCACTCGGTACTTCTGGTGTCGGTGGTGTTGGT

>NC_017333|13|13|2635805-2635915|CRISPRCasFinder
GGTACTTCTGGTGTCGGTGGCGTTGGT	TCGCCTGGCTCACTCGGCACTTCTGGTGTCGGTGGTGTTGGTGTTTCCGGCTCACTC
GGTACTTCTGGTGTCGGTGGTGTTGGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017333.1\|WP_014937076.1\|2622854_2623640_-\|tandem-type-lipoprotein	unknown	unknown	gnl\|CDD\|367972
NC_017333.1\|WP_014653252.1\|2628073_2629825_+\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NC_017333.1\|WP_001117057.1\|2644794_2645211_-\|DUF2188-domain-containing-protein	unknown	unknown	gnl\|CDD\|227213
NC_017333.1\|WP_000721337.1\|2630952_2631819_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl\|CDD\|224131
NC_017333.1\|WP_000274558.1\|2642108_2642786_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_017333.1\|WP_000074000.1\|2642942_2643707_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NC_017333.1\|WP_000481425.1\|2639055_2640414_-\|gluconate-permease	unknown	unknown	gnl\|CDD\|129873
NC_017333.1\|WP_000581897.1\|2623887_2624652_-\|tandem-type-lipoprotein	unknown	unknown	gnl\|CDD\|367972
NC_017333.1\|WP_000435037.1\|2649908_2650520_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NC_017333.1\|WP_000289136.1\|2643871_2644564_-\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232
NC_017333.1\|WP_031774865.1\|2624763_2625537_-\|tandem-type-lipoprotein	unknown	unknown	gnl\|CDD\|367972
NC_017333.1\|WP_000282632.1\|2626804_2627998_+\|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl\|CDD\|273211
NC_017333.1\|WP_000876645.1\|2640530_2642084_-\|gluconokinase	unknown	unknown	gnl\|CDD\|130381
NC_017333.1\|WP_000678764.1\|2630108_2630375_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000217726.1\|2630518_2630827_+\|hypothetical-protein	unknown	unknown	unknown
NC_017333.1\|WP_000660709.1\|2648084_2649362_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340877
NC_017333.1\|WP_000586373.1\|2645349_2647173_-\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|224208
NC_017333.1\|WP_016187290.1\|2625779_2626709_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370247
NC_017333.1\|WP_000167480.1\|2650617_2651781_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NC_017333.1\|WP_000083859.1\|2621502_2622858_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238287

Protein	Function_ID	Function_description	E-value
NC_017333.1\|WP_014937076.1\|2622854_2623640_-\|tandem-type-lipoprotein	gnl\|CDD\|367972	pfam04507, DUF576, Csa1 family. This family contains several uncharacterized staphylococcal proteins. These proteins have been called conserved staphylococcal antigens (Csa).	2.08363e-133
NC_017333.1\|WP_014653252.1\|2628073_2629825_+\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NC_017333.1\|WP_001117057.1\|2644794_2645211_-\|DUF2188-domain-containing-protein	gnl\|CDD\|227213	COG4876, COG4876, Uncharacterized protein conserved in bacteria [Function unknown].	1.54722e-61
NC_017333.1\|WP_000721337.1\|2630952_2631819_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	5.5142e-177
NC_017333.1\|WP_000274558.1\|2642108_2642786_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	7.62004e-44
NC_017333.1\|WP_000074000.1\|2642942_2643707_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	3.96069e-33
NC_017333.1\|WP_000481425.1\|2639055_2640414_-\|gluconate-permease	gnl\|CDD\|129873	TIGR00791, Gluconate_permease, gluconate transporter. This family includes known gluconate transporters of E. coli and Bacillus species as well as an idonate transporter from E. coli. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	2.53789e-168
NC_017333.1\|WP_000581897.1\|2623887_2624652_-\|tandem-type-lipoprotein	gnl\|CDD\|367972	pfam04507, DUF576, Csa1 family. This family contains several uncharacterized staphylococcal proteins. These proteins have been called conserved staphylococcal antigens (Csa).	2.21828e-125
NC_017333.1\|WP_000435037.1\|2649908_2650520_+\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	7.11271e-43
NC_017333.1\|WP_000289136.1\|2643871_2644564_-\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	8.50652e-86
NC_017333.1\|WP_031774865.1\|2624763_2625537_-\|tandem-type-lipoprotein	gnl\|CDD\|367972	pfam04507, DUF576, Csa1 family. This family contains several uncharacterized staphylococcal proteins. These proteins have been called conserved staphylococcal antigens (Csa).	3.80143e-129
NC_017333.1\|WP_000282632.1\|2626804_2627998_+\|DNA-(cytosine-5-)-methyltransferase	gnl\|CDD\|273211	TIGR00675, Modification_methylase, DNA-methyltransferase (dcm). All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	1.26934e-125
NC_017333.1\|WP_000876645.1\|2640530_2642084_-\|gluconokinase	gnl\|CDD\|130381	TIGR01314, gntK_FGGY, gluconate kinase, FGGY type. Gluconate is derived from glucose in two steps. This model describes one form of gluconate kinase, belonging to the FGGY family of carbohydrate kinases. Gluconate kinase phosphoryates gluconate for entry into the Entner-Douderoff pathway. [Energy metabolism, Sugars].	0
NC_017333.1\|WP_000083859.1\|2621502_2622858_-\|hypothetical-protein	gnl\|CDD\|238287	cd00519, Lipase_3, Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site. .	0.00130687
NC_017333.1\|WP_000660709.1\|2648084_2649362_-\|MFS-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.24287e-91
NC_017333.1\|WP_000586373.1\|2645349_2647173_-\|FUSC-family-protein	gnl\|CDD\|224208	COG1289, COG1289, Predicted membrane protein [Function unknown].	1.43413e-83
NC_017333.1\|WP_016187290.1\|2625779_2626709_-\|hypothetical-protein	gnl\|CDD\|370247	pfam09019, EcoRII-C, EcoRII C terminal. The C-terminal catalytic domain of the Restriction Endonuclease EcoRII has a restriction endonuclease-like fold with a central five-stranded mixed beta-sheet surrounded on both sides by alpha-helices. It cleaves DNA specifically at single 5' CCWGG sites.	6.01914e-12
NC_017333.1\|WP_000167480.1\|2650617_2651781_-\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.37674e-71

>NC_017333.1|WP_000721337.1|2630952_2631819_-|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MKKIKKAIIPAAGLGTRFLPATKAMPKEMLPILDKPTIQYIVEEAARAGIEDIIIVTGRHKRAIEDHFDSQKELEMVLKEKGKSELLEKVQYSTELANIFYVRQKEQKGLGHAISSARQFIGNEPFAVLLGDDIVESEVPAVKQLIDVYEETGHSVIGVQEVPEADTHRYGIIDPLTKNGRQYEVKKFVEKPAQGTAPSNLAIMGRYVLTPEIFDYLKTQKEGAGNEIQLTDAIERMNNDNQVYAYDFEGERYDVGEKLGFVKTTIEYALKDDSMREELTRFIKELGL
>NC_017333.1|WP_000217726.1|2630518_2630827_+|hypothetical-protein
MTVNIVVSIVFCISMVVLSIYVAITKDFTLISYINQTTIADKHKNQIAYIFALCISLSAVFLMSAILCFEYDFIALAFLFLTIALLLIALFYVCFYKITKYP
>NC_017333.1|WP_000678764.1|2630108_2630375_+|hypothetical-protein
MKGSKQILLIMGIISLIVLFIFTLFIMAQYAKHYEQKSDSSNAHTLNSSSAIIEQHTMSNLASLDLYAPVRNITSSRDIHPIYFMTKD
>NC_017333.1|WP_014653252.1|2628073_2629825_+|phospho-sugar-mutase
MFFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHFYEQQSDIEQREGFESKLTFGTAGIRGKFGLGEGRLNKFTIEKLALGLSRYLNAQTNNPTIVIHYDIRHLSTEFAQIIANVLANHQITVYLPDTYKTTPELSFAVRNLNTTAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELVSRYIEDVGDPLQIDISFSKHNSSYIKPLPKSVAENYIKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLKSLNFNQFNLVEAQCKPDPNFSSVQSANPEDHRAFDQAVELANKSHADLLISTDPDADRLGIAERDAHGHITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELTKSLARYNNVEYKEVLTGFKFIAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDELEQIYQTVGRHEDTLFSHTLEGLEGKKKIESIMTHFRSHPPQEIQGLKVKAIEDYLTSEVHQLDKDTTSQINSPKSNVIRVLFDEGFIALRPSGTEPKIKLYVSLKCPNFDDVAQKINAMIFS
>NC_017333.1|WP_000282632.1|2626804_2627998_+|DNA-(cytosine-5-)-methyltransferase
MYNNIITKNESDNSIPLNYGDFIKEKRNKLNMTQKELADSIGLPKFGDRTIRRWENYETSPSYLEYKTIMNFPDTPPYLNPNIYDYKMIDLFAGIGGTRLGFQLHGNVKCVFSSEWDKFSAKTYKANFGETPKGDITQIIADEIPTHDILVAGFPCQAFSQAGLKKGFNDTRGTLFFDIARILKAKRPKCFLLENVKNLRSHDKGKTFDIIMNTLLELDYDVSSSILRARDFGCPQNRERIYIVGFDKQQIKNAENFSFPEPLPIETSLGSILESNVNDKYTISDRLWYGHQRRKREHKAKGNGFGYSIFNETSPYTNTLSARYYKDGSEILIEQNKKNPRKLTPREAARLQGFPENYIIPVSDTQAYKQFGNSVSVPVVHAIASNIFQVLQQNKNN
>NC_017333.1|WP_016187290.1|2625779_2626709_-|hypothetical-protein
MTNLNNQLKEFKNTIKVERSKLLPSPFDMVYKNFEKLGYHKQNEQFFYDNASIIIDELRNQSWIEFKKIEKEFSKKLYSHLLDQDSENYKNMTVKEGIEKFTSKHTDEIYALQLSNTQSRRSRAGKEFESIIELVLMGANIEFVTQGSIGSGVFESSELAKLVDCVVPGAAEYNLNKRNTSLISTKTSLRERWQEVGDEMSRTKAKEMYLVTLDESISEKTLKLIEKNNIIIVTTKSVIDKNYLNSSNVISFEDMLNELHIQLLQWNNYGYPATELNNKKELYQTLIEKYDGNMFVRNYYENMLSNINV
>NC_017333.1|WP_031774865.1|2624763_2625537_-|tandem-type-lipoprotein
MIHSRKLRLCLYLVLLAVFIGACGMKKEESSKDKQIKENFTKTLNLYPTKNLEDFYDKEGFRDQEFEKGDKGTWIVDSEMVIELKDKKMESRSMVLYINRNTRTTKGNFIVRELWEDSKGYAQSKDTKYPVKMEHNKIIPTKPIADDKLRKEIENFKFFVQYGDFKDINDYKDGDISYNSNVPSYSAKYQLSNDDYNVKQLRKRYDIPTKKAPKLLIKGDGDLKGSSIAHKNLEFTFIENKEENIYFTDSINFKPTE
>NC_017333.1|WP_000581897.1|2623887_2624652_-|tandem-type-lipoprotein
MIHSKKLTLGICLVLLIILIVGYVIMTKTNGRNAQIKEAFNKTLNVYPTKNLEDFYDKEGFRDQEFDKRDKGTWIINSGMNIQLKGGALKSRAMVLYINRNTRTAKGYFLISETTEDKKGYVHNKDKKYPVKMEHNQIIPTKPIRDDKLKKEIENFKFFVQYGDFKDYKDGDISYNPNVPSYSANYQLNNDDYNVQQLRKRYDISTKRAPELKLRGSGDLKGSSVGSKELEFNFIRNKEENVYFTDSINFKPTE
>NC_017333.1|WP_014937076.1|2622854_2623640_-|tandem-type-lipoprotein
MIHSKKLKLCLCLIILSVFIGGCGMKKEESSKDKQIKENFNKTLSLYPTKNLEDFYDKEGFRDEEFEKGDKGTWIIHSKMIIETNGRNMESRGMVLYINRNTRTTKGNFVIREITEDSKGYSDSKDKKYPVKMENNRIVPMKPIHDEKLRKEIEDFKFFVQYGNFKDINDYKDGDISYNPNVPSYSAKYQLSNDDYNVKQLRKRYDIPTKKAPKLLLKGDGDLKGSSVGSKNLEFTFVENKEENIYFTDSVQYTPSEDNNL
>NC_017333.1|WP_000083859.1|2621502_2622858_-|hypothetical-protein
MSQTEYQIKPGNIKANSEETSTVSKISYEIENANNSGLKKGKINEQIEGLKEEGKFPKNLKYLKSYTDPNTGTTTTAFKNKDTGKVTLGMTGTNLHFEEMGNVLKHPFNHSDQDMKDMKEMLKDFGADANIGLGAVTDKDPHFKDTQDFIKDIKKEYEIDTITGHSLGGRDAIILGVSNDIKNIVVYNPAPLSITDFRIIALNNMTYSAIGDIEIKEMLKNYNGHIVRFVSDKDELDGFVSQFMYDTAGEKIVLNNGEGHDMGAFLRKYAQAKILAELRKVKGYEDANNKSFKSVKDNTKSKLGKVEELRVNWLQANGGALTSSQLKLLESVSALIIAEGLSQLVKEESNQLEKMYDNMKDKFQENWKNSQEAGNKIGTKLSHDGVLTALRNGDAYESKFETEPLTKIEQKLKELNDINSDCHNYVSKIKDSVNAIVGNDQLLASQIAGVI
>NC_017333.1|WP_000481425.1|2639055_2640414_-|gluconate-permease
MFNEIWPLISVVLGIVILLVLIIGFKLNTFISLIITSMITALMLGIPLTKIMETIEKGMGSTLGHIALIFGLGAILGKLLADGGGATRIADTLIQKFGQKHVQWAMLVAAFIVGIALFFEVGLVLLIPLVFTVAKRANVSVLKLGLPMVTALSVTHGFLPPHPGPVVIAKELKANVGDVLLYGMIIAIPVTLIAGPIFNKVAQKMIPSAYTREGDISALGAQKEFTDQEMPGFGMSLLTATLPVILMLVSTITQLVTGHDKPTNLFESIIYMIGTAGTAMLIAVLFAIVTMGLMRKRKMNHIMESVTNAIYPIGMMLLIIGGGGTFKQVLIDGGVGNTIAKMFEGTEMSPILLAWIVAAVLRIALGSATVAAISTTGIVLPLLQSSDVNVALVVLAIGAGSVILSHVNDAGFWMFKEYFGLTVKETFLTWSLLETIISVSGIIFILFISLFV
>NC_017333.1|WP_000876645.1|2640530_2642084_-|gluconokinase
MKYMIGVDIGTTSTKSVLYDENGTFIMKHQIGYDLHTPNVDVSEENPDELFDAVLMTIKYIMRESKVNQDDIKFVSFSAQMHSLIAMDQQHQRLTNNITWADNRAAKYATVINEVHDGNAIYQRTGTPIHPMSPLAKIFWMKHEWQDVFQRTAKFADIKTYIFYHLFDRYIIDYSMASATGMFNLETLDWDVGALELLGISEEMLPELVPTTYVMKGMKERYATLMGLNEDTPFVIGASDGVLSNLGVNSVGKGEVAVTIGTSGAIRTVIDKPRTDYKGRIFCYVLTEDHYVIGGPVNNGGVVLRWLRDELLASEVETAKRLGVDPYDVLTQIAKRVKPGADGLIFHPYLAGERAPLWNANARGSFFGLTLSHKKEHMIRAALEGVLYNLYTVYLALIEVMNETPKMIKATGGFAKSEVWRQMMSDIFDTELVVPESYESSCLGACVLGLKAVGDIEDFSIVSSMVGATNNHTPIEENVAVYQELESIFINLSRSLTENYEQISDFQRQHMAENKTQ
>NC_017333.1|WP_000274558.1|2642108_2642786_-|GntR-family-transcriptional-regulator
MYGYPEKWLEGMTTGEGIAAELRLGIVNGHIAEGTLLTENQMAKQFNVSRSPIRDAFKLLQQNQLIQLERMGAHVLPFGEQEKKEMYDLRLMLESFAFSRVKNQERLPIVKEMKKQLEMMKVAVKFEDAESFTKHDFEFHETLIKASNHQYLNSFWSHLKPVMMALVLTSMRQRMQQNPQDFERIHHNHQVFIDAVEQYDSQILKEAFHLNFDDVGKDIEGFWLN
>NC_017333.1|WP_000074000.1|2642942_2643707_-|MerR-family-transcriptional-regulator
MSNYSTGELAKLCNVTTRTIQYYDRKGILKPQGFTEGKRRVYTEQQRQTLELILLLKDLGCALSDIDMLLKGEGTLKTLNTLLTMKQQEINQQVKQQQAVLDKIKNVQYYVNEASTSPITHLKDIEHVMSKSAEMKSIRRNIWISAGIIGIIQYSSIISAILMKNKWPFLIALPFMISYGIGITIYYQRKVAYLCPNCQHIFSPSLWAVIKAKHTATTRRFECPNCHETHYCIEVPKTHMSTEQLEVPRTKNNN
>NC_017333.1|WP_000289136.1|2643871_2644564_-|GTP-pyrophosphokinase-family-protein
MYVDRKPSLYLEDLRHDFKNSLSKFENGDEAFDTLLGFVELDHIYSSALKEISTKLSILDDNFNHIYKHNPIHHMERRVKEMRSLIEKLNRKGLQISAETAKEHILDIAGIRVVCNYLDDIYLIEEMLLKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVFLAERVEVLPVEIQIRTIGMDMWASLEHKIRYKNNAETEKYRDLLKECATEITEVEDKLQQIHSEITE
>NC_017333.1|WP_001117057.1|2644794_2645211_-|DUF2188-domain-containing-protein
MPFTMKGYPEKWKEFEVIKRQKAIEIANAMLKEGYLEKDVVPIAAKKAKDWYRALSKEEIKALEEENFVQFHTATMEKTEVDSEYATTDNEEHIQEQSNQDKSYFDSESIVNQSGGVRQREPLMDGPHPKVVESFKDV
>NC_017333.1|WP_000586373.1|2645349_2647173_-|FUSC-family-protein
MIIPAIIGYLCGNFQFGLLVATGTLAHIYVFKGPSRSKLRTVIICNLAFAICMILGTLTATTPLVFGMTLLIVTVIPFYIFTALKIAGPSSTFFIVTFSLPINLPIAPEEALYRGFAILVGGVLATMMVLITILLSKNKAEEQAIQNDFKLISKLLHAYNDKSAFSQVAKTAVDSFKASDKLLITSNSSSDKLSGRFQKLLLLHTSAQGIYSELLELNAKQIRPLPDELIEMMDHIITQRDDRNKNVRYWRKEVTVTEEFQNLFNHILKIDEMVHANEARIAYEAEMRKPLYSKRIYQNLTLDSIVFRNTLRYAAIMMIAIFIALMFDFEKAYWIPLSAHTVLLGTSTIHAIERGIARGLGTILGVLVLSVILLFSIPTPVAVILMGIAALFTEALVGANYTIAVVFITIQVILMNGLASQNLTINIAFPRVIDVAMGIVIAIIGLFVLGQRTASALLPYVMAEVVRKEATLFHYLFSENQYKDDVYQKNTAMNLSVKLNNMTQVYNAANGELFSDKTLIQNYYPSLFALEEISFMLNRAMANEDRLTINEQLMGEYLATFENIAKHLELNTELEIKILPDLPQYNYIQSAMMNIQHNGFRERDKNV
>NC_017333.1|WP_000660709.1|2648084_2649362_-|MFS-transporter
MKEKRTNVRWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHRMVNEAEKRFIMENRDIVATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSISSLPWLLMFFLILSAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGISMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWFYVKPDQPLIVSDDKAIEK
>NC_017333.1|WP_000435037.1|2649908_2650520_+|DedA-family-protein
MEQIITEFISRFGYAAIFILILLENILPIVPSEIILTFAGLMSVKSHLSILTLFIIATIASFIGLLILYYICRLISEERLYRFIDRHGKWIKLKSKDLKRANDWFKKYGVWAVFICRFIPVLRVLITIPAGVNRMNVVTFTVISLIGTTIWNFGLILLGRTLSDSFGMLMTGLHTYSRIMYVVIIIAVIYFAIRYIGKRKRVK
>NC_017333.1|WP_000167480.1|2650617_2651781_-|MFS-transporter
MTKSNIRLYILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFILFAISRLFQAIGCGIIPLVTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVISIVLFLIIFFIDIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILSVIIFILGTCVGIVPALLATIISKRFEHIKGKVLGVFNFVRYIGMTVGALLIGIISQPLVAFYFTTITIMLIIIFLYIKIGDFQLKYAK

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_017333_7	7.1\|1942971\|26\|NC_017333\|CRISPRCasFinder	1942971-1942996	26	NC_017333.1	2056197-2056222	0	1.0
NC_017333_10	10.1\|2431749\|26\|NC_017333\|CRISPRCasFinder	2431749-2431774	26	NC_017333.1	1732403-1732428	0	1.0
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	980895-980925	1	0.968
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	1019726-1019756	1	0.968
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	2056150-2056180	1	0.968
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	2056260-2056290	1	0.968
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	2137882-2137912	1	0.968
NC_017333_10	10.1\|2431749\|26\|NC_017333\|CRISPRCasFinder	2431749-2431774	26	NC_017333.1	931620-931645	1	0.962
NC_017333_1	1.1\|315294\|25\|NC_017333\|CRISPRCasFinder	315294-315318	25	NC_017333.1	315463-315487	2	0.92
NC_017333_1	1.2\|315350\|25\|NC_017333\|CRISPRCasFinder	315350-315374	25	NC_017333.1	2223141-2223165	2	0.92
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	297275-297305	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	297333-297363	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	297391-297421	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	438220-438250	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	716001-716031	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	840296-840326	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	931556-931586	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	1112635-1112665	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	1212920-1212950	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	1212974-1213004	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	1852270-1852300	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	1942898-1942928	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	2386544-2386574	2	0.935
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	NC_017333.1	2431637-2431667	2	0.935
NC_017333_4	4.1\|935988\|31\|NC_017333\|CRISPRCasFinder	935988-936018	31	NC_017333.1	881036-881066	2	0.935
NC_017333_10	10.1\|2431749\|26\|NC_017333\|CRISPRCasFinder	2431749-2431774	26	NC_017333.1	935765-935790	2	0.923
NC_017333_10	10.1\|2431749\|26\|NC_017333\|CRISPRCasFinder	2431749-2431774	26	NC_017333.1	980700-980725	2	0.923
NC_017333_10	10.1\|2431749\|26\|NC_017333\|CRISPRCasFinder	2431749-2431774	26	NC_017333.1	1417405-1417430	2	0.923
NC_017333_10	10.1\|2431749\|26\|NC_017333\|CRISPRCasFinder	2431749-2431774	26	NC_017333.1	2223179-2223204	2	0.923
NC_017333_10	10.1\|2431749\|26\|NC_017333\|CRISPRCasFinder	2431749-2431774	26	NC_017333.1	2563571-2563596	2	0.923

1. spacer 7.1|1942971|26|NC_017333|CRISPRCasFinder matches to position: 2056197-2056222, mismatch: 0, identity: 1.0

agaatttcaaaaaagaaattctacag	CRISPR spacer
agaatttcaaaaaagaaattctacag	Protospacer
**************************

2. spacer 10.1|2431749|26|NC_017333|CRISPRCasFinder matches to position: 1732403-1732428, mismatch: 0, identity: 1.0

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacatagaagctggcgg	Protospacer
**************************

3. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 980895-980925, mismatch: 1, identity: 0.968

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttggggccc	Protospacer
***************.***************

4. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 1019726-1019756, mismatch: 1, identity: 0.968

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttggggccc	Protospacer
***************.***************

5. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 2056150-2056180, mismatch: 1, identity: 0.968

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttggggccc	Protospacer
***************.***************

6. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 2056260-2056290, mismatch: 1, identity: 0.968

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttggggccc	Protospacer
***************.***************

7. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 2137882-2137912, mismatch: 1, identity: 0.968

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttggggccc	Protospacer
***************.***************

8. spacer 10.1|2431749|26|NC_017333|CRISPRCasFinder matches to position: 931620-931645, mismatch: 1, identity: 0.962

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacatagaagctgacgg	Protospacer
**********************.***

9. spacer 1.1|315294|25|NC_017333|CRISPRCasFinder matches to position: 315463-315487, mismatch: 2, identity: 0.92

ggcgaaaatacagcttacaataatg	CRISPR spacer
ggcgaaaagtcagcttacaataatg	Protospacer
********  ***************

10. spacer 1.2|315350|25|NC_017333|CRISPRCasFinder matches to position: 2223141-2223165, mismatch: 2, identity: 0.92

ttggaacagcaatttctacagacaa	CRISPR spacer
ttggaacaccaattcctacagacaa	Protospacer
******** *****.**********

11. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 297275-297305, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctttgttggggccc	Protospacer
***************.*** ***********

12. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 297333-297363, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctttgttggggccc	Protospacer
***************.*** ***********

13. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 297391-297421, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctttgttggggccc	Protospacer
***************.*** ***********

14. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 438220-438250, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctatgttggggccc	Protospacer
***************.***.***********

15. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 716001-716031, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttgggcccc	Protospacer
***************.*********** ***

16. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 840296-840326, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctttgttggggccc	Protospacer
***************.*** ***********

17. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 931556-931586, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctatgttggggccc	Protospacer
***************.***.***********

18. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 1112635-1112665, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctttgttggggccc	Protospacer
***************.*** ***********

19. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 1212920-1212950, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttctattcgaaattctctgtgttggggccc	Protospacer
***** *********.***************

20. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 1212974-1213004, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttctattcgaaattctctgtgttggggccc	Protospacer
***** *********.***************

21. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 1852270-1852300, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctatgttggggccc	Protospacer
***************.***.***********

22. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 1942898-1942928, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttgtcgaaattctctgtgttggggccc	Protospacer
****** ********.***************

23. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 2386544-2386574, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctttgttggggccc	Protospacer
***************.*** ***********

24. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to position: 2431637-2431667, mismatch: 2, identity: 0.935

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttctttttgaaattctctgtgttggggccc	Protospacer
********.******.***************

25. spacer 4.1|935988|31|NC_017333|CRISPRCasFinder matches to position: 881036-881066, mismatch: 2, identity: 0.935

aagaaccaatacataataaagcataagtgat	CRISPR spacer
aagaaccaatacataataaatcattagtgat	Protospacer
******************** *** ******

26. spacer 10.1|2431749|26|NC_017333|CRISPRCasFinder matches to position: 935765-935790, mismatch: 2, identity: 0.923

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacatagtagcaggcgg	Protospacer
**************** *** *****

27. spacer 10.1|2431749|26|NC_017333|CRISPRCasFinder matches to position: 980700-980725, mismatch: 2, identity: 0.923

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacacagaagctggtgg	Protospacer
*************.*********.**

28. spacer 10.1|2431749|26|NC_017333|CRISPRCasFinder matches to position: 1417405-1417430, mismatch: 2, identity: 0.923

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacacagaaactggcgg	Protospacer
*************.****.*******

29. spacer 10.1|2431749|26|NC_017333|CRISPRCasFinder matches to position: 2223179-2223204, mismatch: 2, identity: 0.923

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacacaaaagctggcgg	Protospacer
*************.*.**********

30. spacer 10.1|2431749|26|NC_017333|CRISPRCasFinder matches to position: 2563571-2563596, mismatch: 2, identity: 0.923

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacacagtagctggcgg	Protospacer
*************.** *********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_017333_1	1.1\|315294\|25\|NC_017333\|CRISPRCasFinder	315294-315318	25	NC_014792	Enterobacteria phage vB_EcoM-VR7, complete genome	154175-154199	3	0.88
NC_017333_1	1.2\|315350\|25\|NC_017333\|CRISPRCasFinder	315350-315374	25	MW117966	Synechococcus phage S-H9-1, complete genome	42366-42390	4	0.84
NC_017333_7	7.1\|1942971\|26\|NC_017333\|CRISPRCasFinder	1942971-1942996	26	NZ_CP053838	Aliiarcobacter faecis strain CCUG 66484 plasmid pAFAEC, complete sequence	17379-17404	4	0.846
NC_017333_7	7.1\|1942971\|26\|NC_017333\|CRISPRCasFinder	1942971-1942996	26	NZ_CP017210	Borreliella burgdorferi strain B331 plasmid B331_cp9, complete sequence	2023-2048	4	0.846
NC_017333_1	1.2\|315350\|25\|NC_017333\|CRISPRCasFinder	315350-315374	25	NZ_CP038259	Acinetobacter baumannii strain 39741 plasmid pEH_gr13, complete sequence	11151-11175	5	0.8
NC_017333_7	7.1\|1942971\|26\|NC_017333\|CRISPRCasFinder	1942971-1942996	26	NC_008443	Borrelia burgdorferi strain Ip21 plasmid, complete sequence	5652-5677	5	0.808
NC_017333_7	7.1\|1942971\|26\|NC_017333\|CRISPRCasFinder	1942971-1942996	26	NC_010631	Nostoc punctiforme PCC 73102 plasmid pNPUN01, complete sequence	3460-3485	5	0.808
NC_017333_7	7.1\|1942971\|26\|NC_017333\|CRISPRCasFinder	1942971-1942996	26	NC_010632	Nostoc punctiforme PCC 73102 plasmid pNPUN02, complete sequence	13739-13764	5	0.808
NC_017333_1	1.2\|315350\|25\|NC_017333\|CRISPRCasFinder	315350-315374	25	NZ_CP047617	Lactococcus raffinolactis strain Lr_19_5 plasmid pLraf_19_5_1, complete sequence	79395-79419	6	0.76
NC_017333_7	7.1\|1942971\|26\|NC_017333\|CRISPRCasFinder	1942971-1942996	26	MK448662	Streptococcus satellite phage Javan97, complete genome	6198-6223	6	0.769
NC_017333_3	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	MN694009	Marine virus AFVG_250M785, complete genome	3170-3200	9	0.71
NC_017333_8	8.1\|2212114\|34\|NC_017333\|CRISPRCasFinder	2212114-2212147	34	NC_027332	Acinetobacter phage YMC13/03/R2096, complete genome	68639-68672	11	0.676
NC_017333_8	8.1\|2212114\|34\|NC_017333\|CRISPRCasFinder	2212114-2212147	34	KY000079	Acinetobacter phage AM24, complete genome	74925-74958	11	0.676

1. spacer 1.1|315294|25|NC_017333|CRISPRCasFinder matches to NC_014792 (Enterobacteria phage vB_EcoM-VR7, complete genome) position: , mismatch: 3, identity: 0.88

ggcgaaaatacagcttacaataatg	CRISPR spacer
gacgaaaatacatattacaataatg	Protospacer
*.**********  ***********

2. spacer 1.2|315350|25|NC_017333|CRISPRCasFinder matches to MW117966 (Synechococcus phage S-H9-1, complete genome) position: , mismatch: 4, identity: 0.84

ttggaacagcaatttctacagacaa	CRISPR spacer
ttggaacagcaatttctactggtat	Protospacer
******************* *..*

3. spacer 7.1|1942971|26|NC_017333|CRISPRCasFinder matches to NZ_CP053838 (Aliiarcobacter faecis strain CCUG 66484 plasmid pAFAEC, complete sequence) position: , mismatch: 4, identity: 0.846

agaatttcaaaaaagaaattctacag	CRISPR spacer
agaatttcaaaaaataaaatctattg	Protospacer
************** *** ****. *

4. spacer 7.1|1942971|26|NC_017333|CRISPRCasFinder matches to NZ_CP017210 (Borreliella burgdorferi strain B331 plasmid B331_cp9, complete sequence) position: , mismatch: 4, identity: 0.846

agaatttcaaaaaagaaattctacag	CRISPR spacer
acaatttcaaaaaagaaatattacac	Protospacer
* ***************** .****

5. spacer 1.2|315350|25|NC_017333|CRISPRCasFinder matches to NZ_CP038259 (Acinetobacter baumannii strain 39741 plasmid pEH_gr13, complete sequence) position: , mismatch: 5, identity: 0.8

ttggaacagcaatttctacagacaa	CRISPR spacer
ctggaacagcaatttctccagaggt	Protospacer
.**************** **** .

6. spacer 7.1|1942971|26|NC_017333|CRISPRCasFinder matches to NC_008443 (Borrelia burgdorferi strain Ip21 plasmid, complete sequence) position: , mismatch: 5, identity: 0.808

agaatttcaaaaaagaaattctacag	CRISPR spacer
ccaatttcaaaaaagaaattttccac	Protospacer
  ******************.* **

7. spacer 7.1|1942971|26|NC_017333|CRISPRCasFinder matches to NC_010631 (Nostoc punctiforme PCC 73102 plasmid pNPUN01, complete sequence) position: , mismatch: 5, identity: 0.808

agaatttcaaaaaagaaattctacag	CRISPR spacer
tgaatgtcaaaaaagaaattcttgaa	Protospacer
 **** ****************  *.

8. spacer 7.1|1942971|26|NC_017333|CRISPRCasFinder matches to NC_010632 (Nostoc punctiforme PCC 73102 plasmid pNPUN02, complete sequence) position: , mismatch: 5, identity: 0.808

agaatttcaaaaaagaaattctacag	CRISPR spacer
tgaatgtcaaaaaagaaattcttgaa	Protospacer
 **** ****************  *.

9. spacer 1.2|315350|25|NC_017333|CRISPRCasFinder matches to NZ_CP047617 (Lactococcus raffinolactis strain Lr_19_5 plasmid pLraf_19_5_1, complete sequence) position: , mismatch: 6, identity: 0.76

ttggaacagcaatttctacagacaa	CRISPR spacer
ctggaacagcaatttctacattatc	Protospacer
.*******************

10. spacer 7.1|1942971|26|NC_017333|CRISPRCasFinder matches to MK448662 (Streptococcus satellite phage Javan97, complete genome) position: , mismatch: 6, identity: 0.769

agaatttcaaaaaagaaattctacag	CRISPR spacer
gctttttcaaaaaagaaattctagac	Protospacer
.   ******************* *

11. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to MN694009 (Marine virus AFVG_250M785, complete genome) position: , mismatch: 9, identity: 0.71

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
attcttttcgtaattttctctgttatgttta	Protospacer
 ********* ******** ****. * ..

12. spacer 8.1|2212114|34|NC_017333|CRISPRCasFinder matches to NC_027332 (Acinetobacter phage YMC13/03/R2096, complete genome) position: , mismatch: 11, identity: 0.676

tgctggtaccacgatgcgtcttgatgtagtgcta	CRISPR spacer
gatcaataccacgatgcgtcttgaagtggtagaa	Protospacer
 .....****************** **.**.  *

13. spacer 8.1|2212114|34|NC_017333|CRISPRCasFinder matches to KY000079 (Acinetobacter phage AM24, complete genome) position: , mismatch: 11, identity: 0.676

tgctggtaccacgatgcgtcttgatgtagtgcta	CRISPR spacer
gatcaataccacgatgcgtcttgaagtggtagaa	Protospacer
 .....****************** **.**.  *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

370474 : 417309

Staphylococcus_phage(92.19%)

integrase,plate,terminase,capsid,protease,tail,head,holin,portal

attL 370364:370381|attR 417540:417557

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
370364:370381	attL	NA	NA	NA	NA
WP_000264185.1\|370474_371680_-\|integrase	site-specific integrase	A7YGM7	Staphylococcus_virus	2.9e-222	99.8
WP_000191464.1\|371790_372405_+	hypothetical protein	M9QRQ8	Staphylococcus_phage	2.5e-105	99.5
WP_001795334.1\|372401_372548_-	hypothetical protein	A0A2I6PEK8	Staphylococcus_phage	1.2e-16	100.0
WP_000825948.1\|372777_373362_-	hypothetical protein	A0A2I6PD77	Staphylococcus_phage	1.4e-68	100.0
WP_000525004.1\|373379_373841_-	hypothetical protein	A0A2K9VBR7	Staphylococcus_phage	1.2e-83	100.0
WP_000333630.1\|373853_374168_-	helix-turn-helix transcriptional regulator	A0A0N9BAW4	Staphylococcus_phage	9.8e-53	100.0
WP_001121027.1\|374319_374556_+	helix-turn-helix transcriptional regulator	A0A2I6PD81	Staphylococcus_phage	1.5e-37	100.0
WP_001148544.1\|374569_375346_+	Rha family transcriptional regulator	A0A2I6PD87	Staphylococcus_phage	1.1e-140	100.0
WP_000939498.1\|375373_375517_+	hypothetical protein	W5R8I6	Staphylococcus_phage	2.5e-16	100.0
WP_000642492.1\|375506_375716_-	hypothetical protein	W5R9J5	Staphylococcus_phage	1.2e-30	100.0
WP_001025401.1\|375771_376017_+	DUF2829 domain-containing protein	A0A2I6PF15	Staphylococcus_phage	5.1e-41	100.0
WP_001128433.1\|375985_376351_-	hypothetical protein	A0A2I6PF07	Staphylococcus_phage	2.4e-63	100.0
WP_001124158.1\|376644_376908_+	helix-turn-helix domain-containing protein	A7TWG0	Staphylococcus_phage	6.3e-45	97.7
WP_001285954.1\|376920_377082_+	DUF1270 domain-containing protein	A7TWM3	Staphylococcus_phage	8.6e-21	100.0
WP_000174994.1\|377160_377484_+	hypothetical protein	A0A2I6PF12	Staphylococcus_phage	5.9e-53	100.0
WP_000985976.1\|377498_377861_+	hypothetical protein	A0A2I6PF03	Staphylococcus_phage	4.9e-56	100.0
WP_000762523.1\|377857_379024_+	DUF2800 domain-containing protein	B5WZM3	Staphylococcus_phage	5.0e-219	98.5
WP_000645042.1\|379049_379607_+	DUF2815 family protein	A0A2I6PF05	Staphylococcus_phage	1.8e-97	100.0
WP_078096488.1\|379675_381628_+	DNA polymerase	A0A2I6PF18	Staphylococcus_phage	0.0e+00	99.1
WP_000113974.1\|381824_382226_+	PVL family protein	A0A2I6PEL5	Staphylococcus_phage	1.2e-68	100.0
WP_000022727.1\|382225_382480_+	DUF3310 domain-containing protein	A0A2I6PEN5	Staphylococcus_phage	1.6e-42	100.0
WP_001802342.1\|382479_382728_+	hypothetical protein	A0A2I6PDB4	Staphylococcus_phage	1.3e-39	95.1
WP_000693989.1\|382741_382948_+	hypothetical protein	A0A2K9VBT9	Staphylococcus_phage	3.0e-34	100.0
WP_000695771.1\|382950_383358_+	hypothetical protein	M9NST1	Staphylococcus_phage	2.6e-74	98.5
WP_000983950.1\|383354_383549_+	hypothetical protein	A0A0U2A067	Staphylococcus_phage	1.4e-25	96.8
WP_000982714.1\|383545_383983_+	hypothetical protein	NA	NA	NA	NA
WP_001105602.1\|383979_384345_+	hypothetical protein	A0A0F6N3K4	Staphylococcus_phage	7.4e-52	97.3
WP_001065067.1\|384337_384586_+	DUF1024 family protein	Q9B0F3	Staphylococcus_virus	1.7e-36	93.9
WP_000185680.1\|384578_385115_+	dUTP diphosphatase	A0A1P8L6E0	Staphylococcus_phage	2.1e-95	100.0
WP_000195803.1\|385151_385358_+	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
WP_000592221.1\|385354_385741_+	hypothetical protein	A7TWI1	Staphylococcus_phage	1.0e-64	100.0
WP_000595260.1\|385737_385890_+	transcriptional activator RinB	A7TWI2	Staphylococcus_phage	2.6e-19	100.0
WP_000265253.1\|385957_386158_+	DUF1514 family protein	A0A2I6PEP5	Staphylococcus_phage	4.9e-26	98.5
WP_000884855.1\|386445_388893_+	virulence-associated E family protein	R4WAL1	Staphylococcus_phage	0.0e+00	99.1
WP_001801650.1\|389001_389100_-	hypothetical protein	A0A2I6PDP6	Staphylococcus_phage	3.7e-11	100.0
WP_000665203.1\|389233_389524_+	VRR-NUC domain-containing protein	A0A2I6PEN7	Staphylococcus_phage	6.5e-51	100.0
WP_078096486.1\|389504_390872_+	DEAD/DEAH box helicase	A0A2I6PE95	Staphylococcus_phage	8.1e-261	99.1
WP_000513702.1\|390884_391322_+	transcriptional regulator	B7T0I6	Staphylococcus_virus	6.1e-77	100.0
WP_000160693.1\|391478_391793_+	HNH endonuclease	A0A2I6PF37	Staphylococcus_phage	2.5e-56	100.0
WP_000778933.1\|391920_392226_+\|terminase	P27 family phage terminase small subunit	A0A2I6PEQ6	Staphylococcus_phage	2.9e-49	100.0
WP_000153550.1\|392215_393907_+\|terminase	terminase large subunit	A0A2I6PE99	Staphylococcus_phage	0.0e+00	98.6
WP_001100664.1\|393911_395150_+\|portal	phage portal protein	A0A2I6PER5	Staphylococcus_phage	6.9e-235	100.0
WP_000061867.1\|395133_395907_+\|protease	Clp protease ClpP	A0A2I6PEQ7	Staphylococcus_phage	9.2e-137	99.6
WP_001142738.1\|395918_397082_+\|capsid	phage major capsid protein	M9QQM0	Staphylococcus_phage	4.2e-218	100.0
WP_000050973.1\|397150_397429_+\|head,tail	phage gp6-like head-tail connector protein	A0A2I6PEQ1	Staphylococcus_phage	2.1e-46	100.0
WP_000395503.1\|397440_397773_+	hypothetical protein	M9QX19	Staphylococcus_phage	1.4e-57	99.1
WP_000110018.1\|397769_398171_+	hypothetical protein	A0A0K1LL98	Staphylococcus_phage	5.2e-67	99.2
WP_001023808.1\|398171_398567_+	DUF3168 domain-containing protein	A0A0K1LKC0	Staphylococcus_phage	5.1e-67	100.0
WP_000807542.1\|398601_399243_+\|tail	tail protein	A0A2I6PE59	Staphylococcus_phage	5.0e-120	99.1
WP_000169130.1\|399334_399790_+	Ig domain-containing protein	Q9B0D4	Staphylococcus_phage	3.1e-76	98.7
WP_000589167.1\|399847_400198_+	hypothetical protein	A0A2I6PEQ2	Staphylococcus_phage	1.1e-55	100.0
WP_000438833.1\|400239_400398_+	hypothetical protein	A0A2I6PES8	Staphylococcus_phage	1.2e-19	100.0
WP_001190533.1\|406610_407435_+\|tail	phage tail family protein	A0A2I6PER3	Staphylococcus_phage	4.1e-159	100.0
WP_000384460.1\|407443_409027_+\|tail	phage tail protein	Q4ZD01	Staphylococcus_virus	3.5e-308	99.8
WP_000179864.1\|409026_409317_+	hypothetical protein	R4WEC3	Staphylococcus_phage	2.1e-49	100.0
WP_000429556.1\|409332_411243_+	hypothetical protein	A0A2I6PF35	Staphylococcus_phage	0.0e+00	99.2
WP_000067142.1\|411242_412709_+\|plate	phage baseplate upper protein	A0A2I6PES7	Staphylococcus_phage	8.4e-272	99.4
WP_001166598.1\|412708_413098_+	DUF2977 domain-containing protein	M9QYR4	Staphylococcus_phage	9.9e-63	99.2
WP_000916021.1\|413090_413255_+	XkdX family protein	Q4ZCZ6	Staphylococcus_virus	4.9e-24	100.0
WP_000466775.1\|413300_413600_+	DUF2951 family protein	M9QRV2	Staphylococcus_phage	5.9e-31	98.0
WP_000339141.1\|413735_414038_+\|holin	phage holin	A0A2I6PF56	Staphylococcus_phage	3.1e-48	100.0
WP_000930254.1\|414049_415504_+	N-acetylmuramoyl-L-alanine amidase	A7TWL1	Staphylococcus_phage	1.8e-282	96.9
WP_000201920.1\|416192_416372_+	hypothetical protein	M9QYR8	Staphylococcus_phage	4.1e-24	100.0
WP_000455172.1\|416393_416921_+	DUF4065 domain-containing protein	M9QX37	Staphylococcus_phage	1.3e-97	99.4
WP_043854724.1\|416892_417309_+	hypothetical protein	M9QRV7	Staphylococcus_phage	5.4e-75	99.3
417540:417557	attR	NA	NA	NA	NA

DBSCAN-SWA_2

481428 : 493273

Staphylococcus_phage(33.33%)

integrase

attL 484450:484470|attR 497955:497975

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000264071.1\|481428_482895_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	5.2e-96	40.5
WP_000424968.1\|482919_484461_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	1.2e-23	32.6
484450:484470	attL	NA	NA	NA	NA
WP_000592970.1\|484554_485691_-\|integrase	site-specific integrase	A0A1S5S7K9	Streptococcus_phage	1.7e-75	42.5
WP_000819103.1\|485774_486560_-	helix-turn-helix transcriptional regulator	A0A1S5S8T5	Streptococcus_phage	1.2e-09	58.6
WP_000494396.1\|486676_486904_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000080597.1\|486949_487210_+	hypothetical protein	NA	NA	NA	NA
WP_000773833.1\|487256_487403_+	hypothetical protein	NA	NA	NA	NA
WP_001058503.1\|487395_487620_+	hypothetical protein	A0A1W6JPA6	Staphylococcus_phage	3.0e-16	61.8
WP_001103964.1\|487620_487920_+	DUF1474 family protein	Q4ZE75	Staphylococcus_phage	1.1e-37	76.8
WP_000985238.1\|488010_490374_+	primase	A0A2H4JCU9	uncultured_Caudovirales_phage	4.4e-137	39.2
WP_001081424.1\|490795_491140_+	hypothetical protein	A0A1W6JQD5	Staphylococcus_phage	9.4e-41	65.2
WP_000884055.1\|491364_491571_+	hypothetical protein	NA	NA	NA	NA
WP_000657541.1\|491557_492616_+	hypothetical protein	NA	NA	NA	NA
WP_000253082.1\|492781_493273_+	hypothetical protein	A0A2H4JB26	uncultured_Caudovirales_phage	6.7e-24	39.2
497955:497975	attR	NA	NA	NA	NA

DBSCAN-SWA_3

818487 : 826307

Hokovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244415.1\|818487_819543_-	two-component system sensor histidine kinase SaeS	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_000149344.1\|819542_820229_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037805.1\|820203_820677_-	DoxX family protein	NA	NA	NA	NA
WP_001093559.1\|821017_821458_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637685.1\|821738_822323_-	hypothetical protein	NA	NA	NA	NA
WP_001062967.1\|822421_823135_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	5.0e-52	43.5
WP_000941336.1\|823138_823558_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446724.1\|823559_824228_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000604516.1\|824578_825172_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	3.1e-39	44.0
WP_001217786.1\|825155_826307_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	2.1e-23	36.1

DBSCAN-SWA_4

838277 : 852593

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663034.1\|838277_839336_+	histidinol-phosphate transaminase	A0A0H3TLT9	Faustovirus	1.5e-20	26.9
WP_000197271.1\|839494_840037_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429003.1\|840773_841691_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	2.8e-07	22.0
WP_014936998.1\|841781_841889_+	hypothetical protein	NA	NA	NA	NA
WP_000193750.1\|841960_843466_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930016.1\|843805_844306_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	2.7e-52	66.2
WP_001068490.1\|844325_845192_-	DMT family transporter	NA	NA	NA	NA
WP_000692521.1\|845993_846392_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_000855505.1\|846354_848460_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|848579_849551_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000876311.1\|849920_850892_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	7.8e-141	80.2
WP_001245567.1\|850878_851835_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.6e-05	57.8
WP_000616865.1\|851831_852593_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	7.2e-17	30.1

DBSCAN-SWA_5

992242 : 1015467

Streptococcus_phage(94.74%)

integrase

attL 980699:980716|attR 1019742:1019759

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
980699:980716	attL	NA	NA	NA	NA
WP_000154905.1\|992242_995896_+	helicase-exonuclease AddAB subunit AddA	A7KV33	Bacillus_phage	7.0e-25	24.7
WP_000670757.1\|996061_996964_+	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_000902814.1\|997290_997680_+	YisL family protein	NA	NA	NA	NA
WP_001291561.1\|997944_999162_-\|integrase	tyrosine-type recombinase/integrase	A0A1S5SEW7	Streptococcus_phage	3.7e-233	100.0
WP_000814511.1\|999243_999447_-	excisionase	A0A1S5SF07	Streptococcus_phage	4.0e-31	100.0
WP_000857133.1\|999907_1000138_-	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	2.7e-36	100.0
WP_000804885.1\|1000134_1000557_-	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	2.5e-72	100.0
WP_001227347.1\|1001061_1001415_+	helix-turn-helix domain-containing protein	A0A1S5SFA6	Streptococcus_phage	1.3e-58	100.0
WP_000336323.1\|1001474_1001642_-	cysteine-rich KTR domain-containing protein	D0R0F6	Streptococcus_phage	1.6e-14	68.0
WP_000691736.1\|1001760_1003680_-	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	99.5
WP_001814923.1\|1003695_1003812_-	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_001224318.1\|1004056_1004989_-	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	3.1e-171	99.4
WP_000769868.1\|1004985_1005987_-	lysozyme family protein	A0A1S5SEZ8	Streptococcus_phage	5.0e-191	100.0
WP_000804748.1\|1005983_1008161_-	membrane protein	A0A1S5SF30	Streptococcus_phage	0.0e+00	100.0
WP_000331163.1\|1008163_1010611_-	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	99.9
WP_000506270.1\|1010594_1011101_-	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	8.6e-91	100.0
WP_000342539.1\|1011075_1011573_-	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.7e-91	100.0
WP_001009056.1\|1011689_1011911_-	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.3e-31	100.0
WP_000398286.1\|1011953_1013159_-	replication initiation factor domain-containing protein	A0A1S5SEX3	Streptococcus_phage	1.1e-232	99.8
WP_000879507.1\|1013181_1013334_-	hypothetical protein	NA	NA	NA	NA
WP_000813488.1\|1013336_1014722_-	DNA translocase FtsK	A0A1S5SFB5	Streptococcus_phage	1.1e-265	100.0
WP_000985015.1\|1014750_1015137_-	YdcP family protein	A0A1S5SF96	Streptococcus_phage	3.0e-64	100.0
WP_000420682.1\|1015152_1015467_-	YdcP family protein	A0A1S5SF38	Streptococcus_phage	5.2e-54	100.0
1019742:1019759	attR	NA	NA	NA	NA

DBSCAN-SWA_6

1042333 : 1094347

Streptococcus_phage(40.0%)

bacteriocin,protease,holin,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000448934.1\|1042333_1043323_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_000258003.1\|1043617_1044013_+	transcriptional regulator Spx	NA	NA	NA	NA
WP_001217731.1\|1044383_1045103_+	adaptor protein MecA	NA	NA	NA	NA
WP_000959279.1\|1045223_1046210_+	competence protein CoiA	NA	NA	NA	NA
WP_000082727.1\|1046257_1048066_+	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	1.2e-46	24.4
WP_000896695.1\|1048525_1049332_-	DsbA family protein	NA	NA	NA	NA
WP_000214070.1\|1049354_1049720_-	truncated hemoglobin	NA	NA	NA	NA
WP_000224612.1\|1049823_1050417_-	CYTH domain-containing protein	NA	NA	NA	NA
WP_001242104.1\|1050602_1050950_+	hypothetical protein	NA	NA	NA	NA
WP_001077683.1\|1050966_1051602_+	GTP pyrophosphokinase family protein	NA	NA	NA	NA
WP_001270834.1\|1051618_1052428_+	NAD kinase	NA	NA	NA	NA
WP_000669942.1\|1052424_1053279_+	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_000062407.1\|1053299_1054685_+	magnesium transporter	NA	NA	NA	NA
WP_000395150.1\|1054694_1056539_+	monovalent cation:proton antiporter family protein	NA	NA	NA	NA
WP_000933200.1\|1056816_1057587_+	enoyl-ACP reductase FabI	NA	NA	NA	NA
WP_000933105.1\|1057783_1058869_-	AI-2E family transporter	NA	NA	NA	NA
WP_000570705.1\|1059210_1060779_+	alanine:cation symporter family protein	NA	NA	NA	NA
WP_000889181.1\|1060920_1061679_+	esterase family protein	NA	NA	NA	NA
WP_000600387.1\|1061872_1062382_+	2'-5' RNA ligase family protein	NA	NA	NA	NA
WP_001154224.1\|1062494_1063685_-	MFS transporter	NA	NA	NA	NA
WP_000258650.1\|1063662_1064838_-	diglucosyl diacylglycerol synthase	NA	NA	NA	NA
WP_000340124.1\|1065268_1066753_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
WP_072434963.1\|1066733_1066994_+	YueH family protein	NA	NA	NA	NA
WP_001049947.1\|1066993_1068556_+	peptide chain release factor 3	A0A1S5SF82	Streptococcus_phage	3.8e-36	28.0
WP_000928413.1\|1068857_1069661_+	TerC family protein	S5MAL1	Bacillus_phage	1.6e-30	40.5
WP_014937014.1\|1069879_1072204_+\|protease	serine protease	W5SAB9	Pithovirus	2.1e-11	27.4
WP_000021872.1\|1072220_1073579_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000414168.1\|1073717_1075229_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_000287260.1\|1075717_1076287_-	competence protein ComK	NA	NA	NA	NA
WP_000876826.1\|1076496_1076715_+	IDEAL domain-containing protein	NA	NA	NA	NA
WP_000668814.1\|1076795_1077782_-	lipoate--protein ligase	NA	NA	NA	NA
WP_000214898.1\|1077980_1078157_+	YkvS family protein	NA	NA	NA	NA
WP_001033867.1\|1078171_1078774_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_099119695.1\|1079073_1079151_+\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_000790905.1\|1079785_1080070_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000870811.1\|1080113_1082078_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000668623.1\|1082080_1082401_+	YxeA family protein	NA	NA	NA	NA
WP_000571192.1\|1082397_1083039_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.0e-19	33.7
WP_001796515.1\|1083126_1083417_-	hypothetical protein	NA	NA	NA	NA
WP_157958947.1\|1083506_1083695_+	poly(glycerol-phosphate) alpha-glucosyltransferase	NA	NA	NA	NA
WP_000766009.1\|1083783_1084140_-	DoxX family protein	NA	NA	NA	NA
WP_001081332.1\|1084630_1085590_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001794249.1\|1085638_1085770_-	hypothetical protein	NA	NA	NA	NA
WP_000867362.1\|1085833_1086049_-	TM2 domain-containing protein	NA	NA	NA	NA
WP_000620945.1\|1086213_1086765_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000070966.1\|1086815_1087754_-	1,4-dihydroxy-2-naphthoate polyprenyltransferase	NA	NA	NA	NA
WP_000190616.1\|1087935_1089297_+	isochorismate synthase MenF	NA	NA	NA	NA
WP_000526673.1\|1089283_1090957_+	2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase	NA	NA	NA	NA
WP_000150215.1\|1090943_1091747_+	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase	NA	NA	NA	NA
WP_000184947.1\|1091739_1092561_+	1,4-dihydroxy-2-naphthoyl-CoA synthase	NA	NA	NA	NA
WP_000284455.1\|1092798_1093128_-	staphostatin B	NA	NA	NA	NA
WP_001088778.1\|1093165_1094347_-\|protease	cysteine protease staphopain B	NA	NA	NA	NA

DBSCAN-SWA_7

1114130 : 1122603

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001807816.1\|1114130_1114613_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.2e-22	44.7
WP_001010409.1\|1114599_1115724_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174055.1\|1115727_1116432_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	2.1e-47	42.1
WP_000848351.1\|1116431_1116695_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666799.1\|1116696_1117368_+	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000032750.1\|1117360_1119550_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.3e-140	39.4
WP_000483707.1\|1119528_1121013_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.5e-46	31.7
WP_000030815.1\|1121005_1122034_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	2.9e-61	41.1
WP_000238668.1\|1122036_1122603_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.7e-29	40.1

DBSCAN-SWA_8

1378776 : 1383964

Staphylococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001807853.1\|1378776_1378974_+	hypothetical protein	A0A1W6JNK0	Staphylococcus_phage	9.9e-11	50.0
WP_074347689.1\|1379660_1379888_+	hypothetical protein	A0A1W6JNK0	Staphylococcus_phage	1.9e-18	72.1
WP_001002341.1\|1380188_1380395_+	hypothetical protein	A0A2H4PQT0	Staphylococcus_phage	5.5e-12	55.2
WP_001788716.1\|1381095_1381206_+	hypothetical protein	NA	NA	NA	NA
WP_000006110.1\|1381598_1381784_+	hypothetical protein	A0A0F6N3H3	Staphylococcus_phage	2.4e-19	78.7
WP_000477490.1\|1382294_1382711_+	hypothetical protein	NA	NA	NA	NA
WP_000974166.1\|1383142_1383727_-	ATP-binding protein	A0A059NT77	Lactococcus_phage	4.4e-30	42.6
WP_001215406.1\|1383790_1383964_-	hypothetical protein	A0A059NT83	Lactococcus_phage	3.6e-09	51.9

DBSCAN-SWA_9

1560497 : 1648879

105

Staphylococcus_phage(74.03%)

integrase,plate,capsid,terminase,protease,tail,head,holin,tRNA,portal

attL 1595434:1595451|attR 1646112:1646129

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000858789.1\|1560497_1561790_-\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	1.9e-54	30.0
WP_000525056.1\|1562111_1564805_-	ATP-dependent helicase	A0A1X9I5C8	Streptococcus_phage	1.4e-46	34.3
WP_000049916.1\|1564828_1565800_-	biotin--[acetyl-CoA-carboxylase] ligase	NA	NA	NA	NA
WP_000361538.1\|1565786_1566989_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	7.1e-35	43.3
WP_000690021.1\|1566993_1568136_-	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA	NA	NA	NA	NA
WP_000839926.1\|1568379_1568697_-	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_031774809.1\|1569031_1569712_-	zinc metallopeptidase	NA	NA	NA	NA
WP_000154694.1\|1569783_1570371_-	DUF1405 domain-containing protein	NA	NA	NA	NA
WP_000005219.1\|1570360_1570936_-	YpiB family protein	G3MAV7	Bacillus_virus	9.3e-09	27.2
WP_000389530.1\|1570949_1572194_-	hypothetical protein	NA	NA	NA	NA
WP_000245908.1\|1572200_1573499_-	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_000776339.1\|1573508_1574573_-	3-dehydroquinate synthase	NA	NA	NA	NA
WP_001269939.1\|1574598_1575765_-	chorismate synthase	A0A291AU41	Pandoravirus	2.6e-34	32.3
WP_000789522.1\|1576151_1576352_-	hypothetical protein	NA	NA	NA	NA
WP_000442480.1\|1576557_1577007_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	2.4e-28	43.8
WP_001096479.1\|1577098_1578058_-	polyprenyl synthetase family protein	A0A1V0SE37	Indivirus	1.3e-10	24.4
WP_000774681.1\|1578059_1578785_-	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_000450555.1\|1578787_1579360_-	heptaprenyl diphosphate synthase component 1	NA	NA	NA	NA
WP_001043863.1\|1579790_1580063_-	HU family DNA-binding protein	A7KV42	Bacillus_phage	4.2e-28	73.3
WP_000161737.1\|1580233_1581232_-	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_000165530.1\|1581248_1582559_-	ribosome biogenesis GTPase Der	NA	NA	NA	NA
WP_000133960.1\|1582780_1583956_-	30S ribosomal protein S1	NA	NA	NA	NA
WP_001825307.1\|1584212_1584404_-	hypothetical protein	NA	NA	NA	NA
WP_001807839.1\|1584520_1584637_-	hypothetical protein	NA	NA	NA	NA
WP_000644390.1\|1584667_1585327_-	(d)CMP kinase	NA	NA	NA	NA
WP_000681742.1\|1585403_1586372_+	asparaginase	NA	NA	NA	NA
WP_001174257.1\|1586486_1587473_-	YpdA family putative bacillithiol disulfide reductase	NA	NA	NA	NA
WP_001807838.1\|1587633_1587750_-	hypothetical protein	NA	NA	NA	NA
WP_000069278.1\|1587875_1589330_-	elastin-binding protein EbpS	NA	NA	NA	NA
WP_000902104.1\|1589482_1590862_-	ATP-dependent DNA helicase RecQ	L7RCS0	Acanthamoeba_polyphaga_moumouvirus	6.4e-56	33.3
WP_001163801.1\|1590851_1591805_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_001151997.1\|1591912_1592161_+	ferredoxin	A0A127AYY7	Bacillus_phage	8.3e-15	48.0
WP_001186909.1\|1592266_1592812_-	ECF transporter S component	NA	NA	NA	NA
WP_001825312.1\|1593215_1594148_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_001807840.1\|1594602_1595499_-	DUF1672 domain-containing protein	NA	NA	NA	NA
1595434:1595451	attL	NA	NA	NA	NA
WP_001825313.1\|1595553_1596483_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000126130.1\|1596573_1596789_-	hypothetical protein	A0ZS61	Staphylococcus_virus	2.0e-25	100.0
WP_043854724.1\|1597004_1597421_-	hypothetical protein	M9QRV7	Staphylococcus_phage	5.4e-75	99.3
WP_000201920.1\|1597940_1598120_-	hypothetical protein	M9QYR8	Staphylococcus_phage	4.1e-24	100.0
WP_001148129.1\|1599020_1600466_-	SH3 domain-containing protein	Q4ZB16	Staphylococcus_virus	1.7e-288	96.9
WP_000354117.1\|1600446_1600884_-\|holin	phage holin	M9QTA6	Staphylococcus_phage	3.8e-71	97.9
WP_000466774.1\|1601019_1601319_-	DUF2951 family protein	M9QRV2	Staphylococcus_phage	2.6e-31	100.0
WP_000916022.1\|1601364_1601529_-	XkdX family protein	M9QX31	Staphylococcus_phage	1.9e-23	98.1
WP_000378889.1\|1601521_1601914_-	DUF2977 domain-containing protein	Q4ZCZ7	Staphylococcus_virus	8.4e-54	92.4
WP_000466776.1\|1601832_1602138_-	DUF2951 family protein	M9QRV2	Staphylococcus_phage	8.9e-27	97.8
WP_000916021.1\|1602183_1602348_-	XkdX family protein	Q4ZCZ6	Staphylococcus_virus	4.9e-24	100.0
WP_001166606.1\|1602340_1602730_-	DUF2977 domain-containing protein	Q4ZCZ7	Staphylococcus_virus	5.4e-61	95.3
WP_000067142.1\|1602801_1604268_-\|plate	phage baseplate upper protein	A0A2I6PES7	Staphylococcus_phage	8.4e-272	99.4
WP_000429556.1\|1604267_1606178_-	hypothetical protein	A0A2I6PF35	Staphylococcus_phage	0.0e+00	99.2
WP_000179864.1\|1606193_1606484_-	hypothetical protein	R4WEC3	Staphylococcus_phage	2.1e-49	100.0
WP_000384460.1\|1606483_1608067_-\|tail	phage tail protein	Q4ZD01	Staphylococcus_virus	3.5e-308	99.8
WP_001190533.1\|1608075_1608900_-\|tail	phage tail family protein	A0A2I6PER3	Staphylococcus_phage	4.1e-159	100.0
WP_000438833.1\|1615112_1615271_-	hypothetical protein	A0A2I6PES8	Staphylococcus_phage	1.2e-19	100.0
WP_000589167.1\|1615312_1615663_-	hypothetical protein	A0A2I6PEQ2	Staphylococcus_phage	1.1e-55	100.0
WP_000169130.1\|1615720_1616176_-	Ig domain-containing protein	Q9B0D4	Staphylococcus_phage	3.1e-76	98.7
WP_000807542.1\|1616267_1616909_-\|tail	tail protein	A0A2I6PE59	Staphylococcus_phage	5.0e-120	99.1
WP_001023808.1\|1616943_1617339_-	DUF3168 domain-containing protein	A0A0K1LKC0	Staphylococcus_phage	5.1e-67	100.0
WP_000110018.1\|1617339_1617741_-	hypothetical protein	A0A0K1LL98	Staphylococcus_phage	5.2e-67	99.2
WP_000395503.1\|1617737_1618070_-	hypothetical protein	M9QX19	Staphylococcus_phage	1.4e-57	99.1
WP_000050973.1\|1618081_1618360_-\|head,tail	phage gp6-like head-tail connector protein	A0A2I6PEQ1	Staphylococcus_phage	2.1e-46	100.0
WP_001142738.1\|1618428_1619592_-\|capsid	phage major capsid protein	M9QQM0	Staphylococcus_phage	4.2e-218	100.0
WP_000061867.1\|1619603_1620377_-\|protease	Clp protease ClpP	A0A2I6PEQ7	Staphylococcus_phage	9.2e-137	99.6
WP_001100664.1\|1620360_1621599_-\|portal	phage portal protein	A0A2I6PER5	Staphylococcus_phage	6.9e-235	100.0
WP_000153552.1\|1621603_1623295_-\|terminase	terminase large subunit	A0A2I6PE99	Staphylococcus_phage	0.0e+00	98.8
WP_000778933.1\|1623284_1623590_-\|terminase	P27 family phage terminase small subunit	A0A2I6PEQ6	Staphylococcus_phage	2.9e-49	100.0
WP_000160693.1\|1623717_1624032_-	HNH endonuclease	A0A2I6PF37	Staphylococcus_phage	2.5e-56	100.0
WP_014532488.1\|1624093_1624627_-	transcriptional regulator	A0A2I6PEN3	Staphylococcus_phage	1.9e-72	99.3
WP_001793488.1\|1624639_1626007_-	DEAD/DEAH box helicase	A0A2I6PE95	Staphylococcus_phage	1.7e-263	100.0
WP_000665203.1\|1625987_1626278_-	VRR-NUC domain-containing protein	A0A2I6PEN7	Staphylococcus_phage	6.5e-51	100.0
WP_001801650.1\|1626411_1626510_+	hypothetical protein	A0A2I6PDP6	Staphylococcus_phage	3.7e-11	100.0
WP_000884855.1\|1626618_1629066_-	virulence-associated E family protein	R4WAL1	Staphylococcus_phage	0.0e+00	99.1
WP_000265253.1\|1629353_1629554_-	DUF1514 family protein	A0A2I6PEP5	Staphylococcus_phage	4.9e-26	98.5
WP_000595260.1\|1629621_1629774_-	transcriptional activator RinB	A7TWI2	Staphylococcus_phage	2.6e-19	100.0
WP_000592221.1\|1629770_1630157_-	hypothetical protein	A7TWI1	Staphylococcus_phage	1.0e-64	100.0
WP_000195803.1\|1630153_1630360_-	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
WP_000185680.1\|1630396_1630933_-	dUTP diphosphatase	A0A1P8L6E0	Staphylococcus_phage	2.1e-95	100.0
WP_001065067.1\|1630925_1631174_-	DUF1024 family protein	Q9B0F3	Staphylococcus_virus	1.7e-36	93.9
WP_001105602.1\|1631166_1631532_-	hypothetical protein	A0A0F6N3K4	Staphylococcus_phage	7.4e-52	97.3
WP_000982714.1\|1631528_1631966_-	hypothetical protein	NA	NA	NA	NA
WP_000983950.1\|1631962_1632157_-	hypothetical protein	A0A0U2A067	Staphylococcus_phage	1.4e-25	96.8
WP_000695771.1\|1632153_1632561_-	hypothetical protein	M9NST1	Staphylococcus_phage	2.6e-74	98.5
WP_000693989.1\|1632563_1632770_-	hypothetical protein	A0A2K9VBT9	Staphylococcus_phage	3.0e-34	100.0
WP_001802342.1\|1632783_1633032_-	hypothetical protein	A0A2I6PDB4	Staphylococcus_phage	1.3e-39	95.1
WP_000022727.1\|1633031_1633286_-	DUF3310 domain-containing protein	A0A2I6PEN5	Staphylococcus_phage	1.6e-42	100.0
WP_000113974.1\|1633285_1633687_-	PVL family protein	A0A2I6PEL5	Staphylococcus_phage	1.2e-68	100.0
WP_078096488.1\|1633883_1635836_-	DNA polymerase	A0A2I6PF18	Staphylococcus_phage	0.0e+00	99.1
WP_000645042.1\|1635904_1636462_-	DUF2815 family protein	A0A2I6PF05	Staphylococcus_phage	1.8e-97	100.0
WP_000762524.1\|1636487_1637654_-	DUF2800 domain-containing protein	Q8SDR9	Staphylococcus_virus	9.1e-221	99.7
WP_000985976.1\|1637650_1638013_-	hypothetical protein	A0A2I6PF03	Staphylococcus_phage	4.9e-56	100.0
WP_000174994.1\|1638027_1638351_-	hypothetical protein	A0A2I6PF12	Staphylococcus_phage	5.9e-53	100.0
WP_001285954.1\|1638429_1638591_-	DUF1270 domain-containing protein	A7TWM3	Staphylococcus_phage	8.6e-21	100.0
WP_001124158.1\|1638603_1638867_-	helix-turn-helix domain-containing protein	A7TWG0	Staphylococcus_phage	6.3e-45	97.7
WP_001128433.1\|1639160_1639526_+	hypothetical protein	A0A2I6PF07	Staphylococcus_phage	2.4e-63	100.0
WP_001025401.1\|1639494_1639740_-	DUF2829 domain-containing protein	A0A2I6PF15	Staphylococcus_phage	5.1e-41	100.0
WP_000642492.1\|1639795_1640005_+	hypothetical protein	W5R9J5	Staphylococcus_phage	1.2e-30	100.0
WP_000939498.1\|1639994_1640138_-	hypothetical protein	W5R8I6	Staphylococcus_phage	2.5e-16	100.0
WP_000435360.1\|1640152_1640596_-	hypothetical protein	W5R971	Staphylococcus_phage	1.5e-75	100.0
WP_000213811.1\|1640643_1640856_-	helix-turn-helix transcriptional regulator	A7TWF1	Staphylococcus_phage	1.6e-30	100.0
WP_000511091.1\|1641007_1641739_+	helix-turn-helix transcriptional regulator	S4SVC5	Staphylococcus_phage	2.9e-132	98.8
WP_000705240.1\|1641809_1641992_+	hypothetical protein	A0A2I6PDR4	Staphylococcus_phage	5.3e-27	100.0
WP_000173647.1\|1641988_1643185_+\|integrase	site-specific integrase	A0A2I6PEN0	Staphylococcus_phage	9.7e-218	99.7
WP_014532489.1\|1643227_1645255_-	hypothetical protein	B5WZK7	Staphylococcus_phage	2.7e-111	95.3
WP_001825329.1\|1645247_1646177_-	DUF1672 domain-containing protein	NA	NA	NA	NA
1646112:1646129	attR	NA	NA	NA	NA
WP_000987760.1\|1646421_1648173_-	two-component system sensor histidine kinase SrrB	A0A1V0SGX0	Hokovirus	1.3e-21	33.3
WP_000064078.1\|1648153_1648879_-	two-component system response regulator SrrA	W8CYM9	Bacillus_phage	3.5e-45	43.0

DBSCAN-SWA_10

1704001 : 1712313

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001213908.1\|1704001_1704787_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
WP_000924214.1\|1704912_1705803_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
WP_001062170.1\|1705812_1707159_-	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	3.4e-54	33.7
WP_000683941.1\|1707272_1708373_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	1.0e-08	30.6
WP_000624563.1\|1708375_1709053_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_001283055.1\|1709183_1710290_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_001217255.1\|1710513_1712313_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.5e-54	36.0

DBSCAN-SWA_11

1781737 : 1790780

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1781737_1782256_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_000595008.1\|1782277_1784551_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	2.1e-64	29.3
WP_000749801.1\|1784753_1787033_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1787307_1787568_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1787586_1788726_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001019177.1\|1788748_1789774_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005766.1\|1789775_1790780_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_12

1925432 : 1985591

Staphylococcus_phage(83.33%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000526541.1\|1925432_1926386_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	6.4e-79	99.3
WP_000764426.1\|1926382_1926946_+	class I SAM-dependent methyltransferase	A0A2H4PQV0	Staphylococcus_phage	7.3e-99	95.7
WP_000757543.1\|1927064_1927466_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266096.1\|1928038_1928866_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_014937042.1\|1928868_1928988_-	hypothetical protein	NA	NA	NA	NA
WP_001196354.1\|1929099_1930101_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7
WP_001008555.1\|1930228_1930687_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	4.1e-68	97.4
WP_001159034.1\|1930699_1931881_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.9e-226	99.7
WP_000493892.1\|1931891_1932524_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.7e-112	99.5
WP_000077346.1\|1932530_1933574_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	3.1e-196	99.1
WP_001261672.1\|1934054_1935557_-	FAD/NAD(P)-binding protein	A0A2H4PQX2	Staphylococcus_phage	5.0e-30	98.6
WP_000221190.1\|1936207_1936522_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	1.3e-52	98.1
WP_000989103.1\|1936521_1937814_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	7.5e-216	94.7
WP_001032832.1\|1937900_1938755_-	glucosaminidase domain-containing protein	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1939030_1939255_-	hypothetical protein	NA	NA	NA	NA
WP_000671058.1\|1939453_1939924_+	RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	5.0e-69	84.6
WP_001153741.1\|1940036_1940480_+	competence protein ComK	NA	NA	NA	NA
WP_001030474.1\|1940466_1940910_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	1.4e-49	77.9
WP_001168915.1\|1941207_1941843_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000492903.1\|1942009_1942630_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001096494.1\|1943192_1943906_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091443.1\|1944164_1944467_+	hypothetical protein	NA	NA	NA	NA
WP_001200546.1\|1944721_1945087_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	6.9e-58	98.3
WP_000623484.1\|1945083_1945437_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	2.3e-18	82.1
WP_000453302.1\|1945686_1946520_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.7e-157	98.9
WP_000366160.1\|1946731_1947640_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	1.3e-137	99.3
WP_000933822.1\|1947764_1948958_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
WP_000109913.1\|1949329_1950922_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	99.6
WP_016187361.1\|1951218_1951965_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	7.8e-141	98.0
WP_000672013.1\|1951969_1952443_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	7.2e-84	98.7
WP_000718107.1\|1952508_1952766_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778553.1\|1952762_1953764_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	3.3e-163	86.5
WP_000348381.1\|1953768_1955247_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	6.7e-277	95.5
WP_016187363.1\|1955405_1955861_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	8.3e-77	96.6
WP_078096487.1\|1956684_1957158_-\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	8.7e-29	45.0
WP_001085423.1\|1957138_1957669_-\|transposase	transposase	NA	NA	NA	NA
WP_000166623.1\|1957780_1958143_-	cystatin-like fold lipoprotein	NA	NA	NA	NA
WP_000850646.1\|1958189_1958783_-	hypothetical protein	NA	NA	NA	NA
WP_000247482.1\|1958788_1959817_-	CHAP domain-containing protein	NA	NA	NA	NA
WP_000875438.1\|1959806_1961738_-	hypothetical protein	NA	NA	NA	NA
WP_000274938.1\|1961837_1962239_-	hypothetical protein	NA	NA	NA	NA
WP_001251196.1\|1962243_1963602_-	cell division protein FtsK	A0A1S5SFB5	Streptococcus_phage	2.7e-46	30.1
WP_000696096.1\|1963606_1963939_-	hypothetical protein	NA	NA	NA	NA
WP_000990409.1\|1963935_1964166_-	hypothetical protein	NA	NA	NA	NA
WP_000217371.1\|1964169_1964388_-	hypothetical protein	NA	NA	NA	NA
WP_000364354.1\|1964399_1966895_-	ATP-binding protein	NA	NA	NA	NA
WP_000358151.1\|1966929_1967319_-	hypothetical protein	NA	NA	NA	NA
WP_000369240.1\|1967324_1967585_-	hypothetical protein	NA	NA	NA	NA
WP_001225822.1\|1967589_1968666_-	conjugal transfer protein	NA	NA	NA	NA
WP_001059817.1\|1968740_1969103_-	hypothetical protein	NA	NA	NA	NA
WP_000019150.1\|1969282_1970422_-	replication initiation factor domain-containing protein	NA	NA	NA	NA
WP_001007543.1\|1970587_1971013_-	hypothetical protein	NA	NA	NA	NA
WP_000595049.1\|1971034_1971358_-	DUF961 family protein	NA	NA	NA	NA
WP_000070644.1\|1972369_1973365_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	1.3e-69	94.8
WP_000669036.1\|1973440_1974067_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	9.9e-81	84.1
WP_000627549.1\|1974107_1974452_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	5.1e-55	96.5
WP_000414230.1\|1974549_1975122_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	3.5e-24	93.1
WP_000864133.1\|1975319_1975877_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	1.1e-78	98.1
WP_000375476.1\|1976247_1976424_-	hypothetical protein	NA	NA	NA	NA
WP_000070813.1\|1976434_1976818_-	hypothetical protein	NA	NA	NA	NA
WP_000196442.1\|1977266_1977548_-\|transposase	IS3 family transposase	A0A0C5AJ30	Paenibacillus_phage	3.2e-23	63.4
WP_000731425.1\|1977790_1978234_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000747800.1\|1978233_1978677_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000221417.1\|1979211_1981635_+	polysaccharide lyase 8 family protein	NA	NA	NA	NA
WP_001034579.1\|1981760_1982138_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000439997.1\|1982346_1982790_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000877848.1\|1982832_1983138_+	hypothetical protein	NA	NA	NA	NA
WP_014532497.1\|1983207_1983597_+	hypothetical protein	NA	NA	NA	NA
WP_000566444.1\|1983576_1984221_-	ATP-binding protein	A0A059NT77	Lactococcus_phage	4.6e-49	46.6
WP_001215402.1\|1984355_1985591_-\|transposase	IS21 family transposase	A0A059NT83	Lactococcus_phage	2.8e-103	49.1

DBSCAN-SWA_13

2067352 : 2109840

Bacillus_virus(27.27%)

integrase,protease,transposase,tRNA

attL 2073269:2073284|attR 2111715:2111730

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000545368.1\|2067352_2068780_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_000027924.1\|2068792_2070250_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_000170162.1\|2070251_2070554_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_000957030.1\|2070920_2072459_+	sodium/proline symporter PutP	NA	NA	NA	NA
WP_000831695.1\|2072547_2073747_-	CamS family sex pheromone protein	NA	NA	NA	NA
2073269:2073284	attL	NA	NA	NA	NA
WP_000774571.1\|2073759_2075763_-	NAD-dependent DNA ligase LigA	A0A0K2QQN8	Ralstonia_phage	4.4e-114	36.1
WP_000992924.1\|2075766_2077959_-	DNA helicase PcrA	A7KV33	Bacillus_phage	1.0e-135	42.2
WP_000272065.1\|2077955_2078648_-	heptaprenylglyceryl phosphate synthase	NA	NA	NA	NA
WP_001165363.1\|2078819_2079122_-	hypothetical protein	NA	NA	NA	NA
WP_000572878.1\|2079230_2080526_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.6e-16	32.9
WP_000827738.1\|2081374_2082541_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
WP_000434536.1\|2082571_2082895_+	staphostatin A	NA	NA	NA	NA
WP_000669861.1\|2083187_2083361_-	NETI motif-containing protein	NA	NA	NA	NA
WP_000011542.1\|2083341_2083944_-	DUF2179 domain-containing protein	NA	NA	NA	NA
WP_000040870.1\|2084213_2085035_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	6.1e-70	53.1
WP_000284428.1\|2085027_2086497_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	1.7e-107	44.9
WP_000897642.1\|2086680_2087757_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
WP_001177819.1\|2087776_2088571_+	prephenate dehydratase	NA	NA	NA	NA
WP_001802312.1\|2088642_2088750_+	hypothetical protein	NA	NA	NA	NA
WP_000323172.1\|2088760_2090323_-	SLC13 family permease	NA	NA	NA	NA
WP_000275718.1\|2090527_2091625_-	pectate lyase	U5PWM6	Bacillus_phage	3.3e-47	34.6
WP_000149686.1\|2091996_2092557_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
WP_001140871.1\|2092609_2093539_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
WP_001826057.1\|2093731_2093905_-	hypothetical protein	NA	NA	NA	NA
WP_001021224.1\|2093956_2095336_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_000181321.1\|2095455_2096484_-	lactonase family protein	NA	NA	NA	NA
WP_001284658.1\|2096943_2097324_-	penicillinase repressor BlaI	NA	NA	NA	NA
WP_001096367.1\|2097313_2099071_-	beta-lactam sensor/signal transducer BlaR1	NA	NA	NA	NA
WP_000733622.1\|2099177_2100023_+	penicillin-hydrolyzing class A beta-lactamase BlaZ	A0A1B0VBP7	Salmonella_phage	4.4e-31	33.9
WP_000612779.1\|2100336_2100747_+	YolD-like family protein	U3PG23	Staphylococcus_phage	3.1e-30	53.5
WP_000368919.1\|2100789_2102160_-	hypothetical protein	NA	NA	NA	NA
WP_000410574.1\|2102164_2102530_-\|transposase	transposase	NA	NA	NA	NA
WP_000026850.1\|2102538_2104602_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_000706213.1\|2104604_2105717_-\|integrase	tyrosine-type recombinase/integrase	P97010	Streptococcus_pyogenes_phage	1.7e-11	31.6
WP_000267034.1\|2106263_2106437_-	hypothetical protein	NA	NA	NA	NA
WP_001188070.1\|2106887_2107928_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_078055982.1\|2108819_2109356_-\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	7.6e-29	43.6
WP_000746371.1\|2109336_2109840_-\|transposase	transposase	NA	NA	NA	NA
2111715:2111730	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NC_017333.1|WP_000384171.1|1939030_1939255_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NC_017333.1|WP_000850646.1|1958189_1958783_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_017333.1|WP_000384171.1|1939030_1939255_-|hypothetical-protein

1939030_1939255_-

74 aa aa

1925432-1985591

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_017333_3	Orphan	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	1942928-1942898	2

1. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to NC_017333 position: 1942928-1942898, mismatch: 2

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttgtcgaaattctctgtgttggggccc	Protospacer
****** ********.***************

NC_017333.1|WP_000850646.1|1958189_1958783_-|hypothetical-protein

1958189_1958783_-

197 aa aa

1925432-1985591

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_017333_3	Orphan	3.1\|886639\|31\|NC_017333\|CRISPRCasFinder	886639-886669	31	1942928-1942898	2

1. spacer 3.1|886639|31|NC_017333|CRISPRCasFinder matches to NC_017333 position: 1942928-1942898, mismatch: 2

tttcttttcgaaattttctgtgttggggccc	CRISPR spacer
tttcttgtcgaaattctctgtgttggggccc	Protospacer
****** ********.***************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_017333

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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