CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_006582	Bacillus clausii KSM-K16, complete genome	10 crisprs	csa3,cas3,cas14j,DinG,casR,DEDDh,cas8c,WYL,cas2,cas1,cas4,cas7,cas5	10	8	5	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_006582_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006582_1

1676244-1676326

Orphan

Consensus_repeat	Method
AAAACCCCCCAGTAATGGGGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_006582_1

>merge|NC_006582|1|1676244-1676326|CRISPRCasFinder
AAAACCCCCCAGTAATGGGGAGCGAGGTTGTCGACAAAGTCGATAACCGCCATCAGACTGAAAACTCCCCAGTAATGGGGAGC

>NC_006582|1|1|1676244-1676326|CRISPRCasFinder
AAAACCCCCCAGTAATGGGGAGC	GAGGTTGTCGACAAAGTCGATAACCGCCATCAGACTG
AAAACTCCCCAGTAATGGGGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_006582.1\|WP_011246393.1\|1672389_1673484_+\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|236489
NC_006582.1\|WP_011246398.1\|1677513_1678113_+\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NC_006582.1\|WP_011246392.1\|1671550_1672399_+\|carboxylating-nicotinate-nucleotide-diphosphorylase	unknown	unknown	gnl\|CDD\|181221
NC_006582.1\|WP_011246391.1\|1670037_1671570_+\|L-aspartate-oxidase	unknown	unknown	gnl\|CDD\|236147
NC_006582.1\|WP_011246396.1\|1676336_1676711_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|259980
NC_006582.1\|WP_011246388.1\|1667398_1668274_+\|prephenate-dehydratase	unknown	unknown	gnl\|CDD\|237013
NC_006582.1\|WP_011246402.1\|1680446_1681598_+\|tRNA-guanosine(34)-transglycosylase-Tgt	unknown	unknown	gnl\|CDD\|234642
NC_006582.1\|WP_011246405.1\|1682529_1682994_+\|DUF421-domain-containing-protein	unknown	unknown	gnl\|CDD\|225205
NC_006582.1\|WP_011246387.1\|1666939_1667383_+\|ACT-domain-containing-protein	unknown	unknown	gnl\|CDD\|179848
NC_006582.1\|WP_011246395.1\|1675405_1676242_+\|YhcN/YlaJ-family-sporulation-lipoprotein	unknown	unknown	gnl\|CDD\|378211
NC_006582.1\|WP_011246400.1\|1679122_1679326_+\|DUF2905-domain-containing-protein	unknown	unknown	gnl\|CDD\|378570
NC_006582.1\|WP_011246386.1\|1665467_1666754_+\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237046
NC_006582.1\|WP_011246389.1\|1668290_1668827_-\|transcription-repressor-NadR	unknown	unknown	gnl\|CDD\|224740
NC_006582.1\|WP_011246404.1\|1682014_1682395_-\|TIGR04086-family-membrane-protein	unknown	unknown	gnl\|CDD\|274969
NC_006582.1\|WP_011246394.1\|1673797_1675327_+\|SafA/ExsA-family-spore-coat-assembly-protein	unknown	unknown	gnl\|CDD\|131945
NC_006582.1\|WP_011246403.1\|1681643_1681907_+\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|376903
NC_006582.1\|WP_011246399.1\|1678128_1679130_+\|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl\|CDD\|234619
NC_006582.1\|WP_011246401.1\|1679404_1680433_+\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	unknown	unknown	gnl\|CDD\|234666
NC_006582.1\|WP_011246390.1\|1668834_1669950_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_006582.1\|WP_011246397.1\|1676864_1677383_+\|intercompartmental-signaling-factor-BofC	unknown	unknown	gnl\|CDD\|370208

Protein	Function_ID	Function_description	E-value
NC_006582.1\|WP_011246393.1\|1672389_1673484_+\|quinolinate-synthase-NadA	gnl\|CDD\|236489	PRK09375, PRK09375, quinolinate synthase NadA.	1.0567e-146
NC_006582.1\|WP_011246398.1\|1677513_1678113_+\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	1.72657e-84
NC_006582.1\|WP_011246392.1\|1671550_1672399_+\|carboxylating-nicotinate-nucleotide-diphosphorylase	gnl\|CDD\|181221	PRK08072, PRK08072, carboxylating nicotinate-nucleotide diphosphorylase.	1.72728e-170
NC_006582.1\|WP_011246391.1\|1670037_1671570_+\|L-aspartate-oxidase	gnl\|CDD\|236147	PRK08071, PRK08071, L-aspartate oxidase; Provisional.	1.24138e-178
NC_006582.1\|WP_011246396.1\|1676336_1676711_-\|hypothetical-protein	gnl\|CDD\|259980	cd13913, ba3_CcO_II_C, C-terminal cupredoxin domain of Ba3-like heme-copper oxidase subunit II. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea, which catalyze the reduction of O2 and simultaneously pump protons across the membrane. It has been proposed that archaea acquired heme-copper oxidases through gene transfer from gram-positive bacteria. The ba3 family contains oxidases that lack the conserved residues that form the D- and K-pathways in CcO and ubiquinol oxidase. Instead, they contain a potential alternative K-pathway. Additional proton channels have been proposed for this family of oxidases but none have been identified definitively.	1.5889e-07
NC_006582.1\|WP_011246388.1\|1667398_1668274_+\|prephenate-dehydratase	gnl\|CDD\|237013	PRK11898, PRK11898, prephenate dehydratase; Provisional.	2.4737e-146
NC_006582.1\|WP_011246402.1\|1680446_1681598_+\|tRNA-guanosine(34)-transglycosylase-Tgt	gnl\|CDD\|234642	PRK00112, tgt, queuine tRNA-ribosyltransferase; Provisional.	0
NC_006582.1\|WP_011246405.1\|1682529_1682994_+\|DUF421-domain-containing-protein	gnl\|CDD\|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	6.21961e-12
NC_006582.1\|WP_011246387.1\|1666939_1667383_+\|ACT-domain-containing-protein	gnl\|CDD\|179848	PRK04435, PRK04435, ACT domain-containing protein.	1.44937e-82
NC_006582.1\|WP_011246395.1\|1675405_1676242_+\|YhcN/YlaJ-family-sporulation-lipoprotein	gnl\|CDD\|378211	pfam09580, Spore_YhcN_YlaJ, Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ). This entry contains YhcN and YlaJ, which are predicted lipoproteins that have been detected as spore proteins but not vegetative proteins in Bacillus subtilis. Both appear to be expressed under control of the RNA polymerase sigma-G factor. The YlaJ-like members of this family have a low-complexity, strongly acidic, 40-residue C-terminal domain.	6.73635e-14
NC_006582.1\|WP_011246400.1\|1679122_1679326_+\|DUF2905-domain-containing-protein	gnl\|CDD\|378570	pfam11146, DUF2905, Protein of unknown function (DUF2905). This is a family of bacterial proteins conserved of unknown function.	1.9819e-15
NC_006582.1\|WP_011246386.1\|1665467_1666754_+\|GTPase-ObgE	gnl\|CDD\|237046	PRK12297, obgE, GTPase CgtA; Reviewed.	0
NC_006582.1\|WP_011246389.1\|1668290_1668827_-\|transcription-repressor-NadR	gnl\|CDD\|224740	COG1827, COG1827, Predicted small molecule binding protein (contains 3H domain) [General function prediction only].	3.25624e-45
NC_006582.1\|WP_011246404.1\|1682014_1682395_-\|TIGR04086-family-membrane-protein	gnl\|CDD\|274969	TIGR04086, hypothetical_protein, putative membrane protein, TIGR04086 family. Members of this family of strongly hydrophobic putative transmembrane protein average about 125 amino acids in length and occur mostly, but not exclusively, in the Firmicutes. Members are quite diverse in sequence. The function is unknown.	3.35013e-18
NC_006582.1\|WP_011246394.1\|1673797_1675327_+\|SafA/ExsA-family-spore-coat-assembly-protein	gnl\|CDD\|131945	TIGR02899, hypothetical_conserved_protein, spore coat assembly protein SafA. SafA (YrbB) (SafA) of Bacillus subtilis is a protein found at the interface of the spore cortex and spore coat, and is dependent on SpoVID for its localization. This model is based on the N-terminal LysM (lysin motif) domain (see pfamAM model pfam01476) of SafA and, from several other spore-forming species, the protein with the most similar N-terminal region. However, this set of proteins differs greatly in C-terminal of the LysM domaim; blocks of 12-residue and 13-residue repeats are found in the Bacillus cereus group, tandem LysM domains in Thermoanaerobacter tengcongensis MB4, etc. in which one of which is found in most examples of endospore-forming bacteria. [Cellular processes, Sporulation and germination].	2.21073e-13
NC_006582.1\|WP_011246403.1\|1681643_1681907_+\|preprotein-translocase-subunit-YajC	gnl\|CDD\|376903	pfam02699, YajC, Preprotein translocase subunit. See.	2.44908e-31
NC_006582.1\|WP_011246399.1\|1678128_1679130_+\|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl\|CDD\|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NC_006582.1\|WP_011246401.1\|1679404_1680433_+\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	gnl\|CDD\|234666	PRK00147, queA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional.	0
NC_006582.1\|WP_011246390.1\|1668834_1669950_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	3.30844e-136
NC_006582.1\|WP_011246397.1\|1676864_1677383_+\|intercompartmental-signaling-factor-BofC	gnl\|CDD\|370208	pfam08955, BofC_C, BofC C-terminal domain. The C-terminal domain of the bacterial protein 'bypass of forespore C' contains a three-stranded beta-sheet and three alpha-helices. Its exact function is, as yet, unknown.	6.39705e-25

>NC_006582.1|WP_011246395.1|1675405_1676242_+|YhcN/YlaJ-family-sporulation-lipoprotein
MKKTALSFICASVLLTGLAGCGTQDNNRAGMQPNTYRNQEANLNGDNNFNNRNYPYYGPNAYNTNDKTFFDDNRFSNKNQRMNRTNQYNQGRNGYVRGITGNNRPGMVDENGFLNRRADYGNRGMNFQRATTNKDGNRGINAQRSTNQDGNMRQGMETEEVRYHRNYDGDRVEEIREEVEKIDGVREARVIINRDDVVVGYEQDEKADDVKQHVENRVRKLAGEGKNVVVSTDNNIYTNMRKMDDKLRSGAAFDDVRDTFTDMMRDLGNAAKRPFQNK
>NC_006582.1|WP_011246394.1|1673797_1675327_+|SafA/ExsA-family-spore-coat-assembly-protein
MRIHIVQKGDTLWKLAEKYEVDYEHLKEANPNLTNPEMLMPGMKVKVPAGSVAVRKEQKKTTPKAKEVDKKPQKAKEQSVKPPKKPELKASEKTQAANVAPAPPYYGQTQQGVAKPPEYPPLPPKPPCTPCQGNAFQEFAPQANMYQQSYAPNQQLYSQQMNQPPSYQPQANQPQSYQPQSYQPQANQPQSYQPQSYQPQANQPQSYQPQSYQPQANQPQSYQPQSYQPQANQPQSYQPQIFQPQAYGENAQLQAQSHGPKQQESAGKHQPLPQDKKDNEAGEWNGVQPQAHKGSSKSGIHGQQSPWGSNAPFVQQSGGPNQQSYPIQENQNKGFQGQQNTNFTPWPQQENKGWNQEQAYAHQVEMNWGQSNGAQPFSQQMDINWGQYRYSPYQGEIGDAAPFQSYPGWQPAALPQMPVANSYPPPQTPFFAPGTLNQQAGPYRQPPVGQLDDQSYQQPHYMNQAPSFLTGPYAAQPQQWAHPQSPYLQEQEYEPEEQINAYEEEDQQD
>NC_006582.1|WP_011246393.1|1672389_1673484_+|quinolinate-synthase-NadA
MQVMQPARLPHHYREMSSAEKEARIREAKAFFGNDLLIPGHHYQREDVIQFADFTGDSLQLAQLCGQTSSANIVFCGVHFMAETADMLTSREQHVILPDLAAGCSMADMASIAQTERAWEALTERFGDTILPLTYVNSTAEIKAFCGRHGGACVTSSNAKNMVQWAFAQKPRVMFLPDQHLGRNTAFALGIPLEKMAVWNPHTHELELLPGANIEEIIVILWKGHCSVHEKFTVEQIKNVRDRSPHTQVIVHPECTHEVVQAADKAGSTHYIIETLKQAEPGTSWAIGTEMNLVNRLAKQHPDKQVFSLHSTMCLCLTMNRIDLDHLAWSLDLLREGKRQFEITVAEDVAAEARTALARMLATV
>NC_006582.1|WP_011246392.1|1671550_1672399_+|carboxylating-nicotinate-nucleotide-diphosphorylase
MNPLKLDQQLRGFLAEDIGYGDRTAEALFTVERAEAVIVAKGEGIFAGTQVVNQLYALLDSDIEVELFVRDGEQVKRGQQLARFTGPVKSLLSGERVLLNLLQRMCGIATLTAKAVEELGDPSIRVCDTRKTAPGLRMFDKFAVRIGGGANHRFGLDDALMLKENHIAASTSIAAAIEKARAYAGPMAKIEVETTTLDEVKEAVAAQADVIMFDNATPEAIRTYLAYVPAGIKTEASGGITMANLRQFANTGVDFLSLGFLTHSVVALDLSMLIQKGEGQCK
>NC_006582.1|WP_011246391.1|1670037_1671570_+|L-aspartate-oxidase
MKKKSVIIVGAGIAGLMAAHKLADKAEVSLLMKAGRLDSNSCMAQGGIAAAVGETDHPTLHARDTFVAGSGFNAFKRASELARQAPAMIKELDALGVPFEKAAGQYVLGHEGAHSKRRILHAYQDQTGLAVVETLWRTLSENVHVYENQYVLELIVKNQTIQGVRTVNHAFYGDCVVIATGGSGQLYENSSNEQRATGDGLMLAYRAGAVLKDLEFMQFHPTILKGKEPSLISEAVRGEGAYLVNRAGHRLMGKWAKGELEGRDVVAATLHKALQSGENVYLDARHLHDFPSRFPAIYRRLQRNGYDVCKDLIPIEPGAHFLCGGIETDRFGRTSVNGLYAIGEAACTGVHGANRLASNSLVEALVYGQAVAAALLADPQTKAGAVKPQPNKALIHGLPERSELQKMMSAYAGIERDAYRLQTVANWLSSFQQMPKKMVVHVDDLETGTMYELATLVVKAALLRTETRGTHRRSDYPSADEQWRKRSICFSVQNKAFVKTEEREYEPAQA
>NC_006582.1|WP_011246390.1|1668834_1669950_-|cysteine-desulfurase
MYYLDYSATTPLSPLCLDVYQKTAQLAFANSNSLHTFGLEARAILEQARTKFASLLRLTEEELYFTGSGSESNFLAIVSLAFAYRNKGQHLVSTKTEHPSVLEALHYLEKHGYEITYVPVTEEGNVTVEALRASLRPDTVLASIAVASSEIGTVQDIAHLSNVLRSRGILFHSDCVQALGKIEIDFSLLDAASFSAHKLYAPKGTGAVYLSKRLHWRGFYEQARHESGFRPGTVDTPAVAAFASAVEHALSIRKTRMAELAELRDTIIRQLTATGHFQLVGSKKERLPFHIGMLVKGWSGQQFMLECDRAGFAIATGSACQAGQTSPPLSLLALGLTNEQADRYVRVTLGEPTTEDEVGMFIEHCTKIVCR
>NC_006582.1|WP_011246389.1|1668290_1668827_-|transcription-repressor-NadR
MRKEKKLKSEERRAAIVEWLKKENAPLKGSDLAKRAGVSRQVVVQDMSLLKAKGEPIFATAQGYMYLAPATQQKVQRLIAVQHRPEDTREELYTFVDHGLTVINVSIEHAIYGELTGAMHISNRQEVDAFCATLAKTKASLLSELTEGVHLHLVEGQNEAQVEKAIAALREKSFLLEE
>NC_006582.1|WP_011246388.1|1667398_1668274_+|prephenate-dehydratase
MKKVGFLGPKGTFTEMAAYSLFPKEELVPLKTIPKVLDLAFAKGIDYAVVPIENAIEGTVNITLDYLIHHKPMPIVASISLEIAQHLLFSPNKDRETFVPKKVVSHPQAIAQCHQFLQKNYPEIEIEYADSTGSAAAWLAENPNADACVIANAQAASTYGLAVAQGDIHDFEHNRTRFIVLTAKKEQAPHIVGPEHTGDKTTLMVTLPSDFAGALHQVLSAFAWRKLNLSKIESRPTKTGLGNYFFLIDIDQLMDDVLVPGAIAELTALGCKVEVLGSYATYSSKATASIN
>NC_006582.1|WP_011246387.1|1666939_1667383_+|ACT-domain-containing-protein
MSKKQFYLVREDMLTDAMQRTLEAKALLSAGKVRKINEAVHRVGLSRSAFYKYKDGIFPFHAIAKERIMTFSINLADRSGTLSQLLNIVADTGANILTINQTIPLQGRANITLSVDTAPIEIDINELFERMEALESVERVELVGSGS
>NC_006582.1|WP_011246386.1|1665467_1666754_+|GTPase-ObgE
MFVDKVKVYAKGGDGGNGMVAYRREKYVPDGGPAGGDGGRGASVILEVDEGLRTLMDFRYNKHFKGKRGEHGMSKNMHGKKAEDLVVKVPPGTMVTDEETGALLADLTTHGQRAVVAKGGRGGRGNVRFVTPANPAPDHAENGEPGEERNLLLELKVLADVGLVGFPSVGKSTLLSIVSAAKPKIAEYHFTTITPNLGVVDTQDGRSFVMADLPGLIEGAHEGVGLGHQFLRHIERTRVIVHIVDMSAMEGRDPVEDYHKINEELSQYNYRLTERPQLVVANKMDMPEANENLKRFKEALGEETKIFPVSAITKDGVRELMLAIADELEHAPEFPLHDSEEQVEGRVLYKHELPIEPFTITRGDDGVFELSGAELERAFKMTDFAREESVRRFARRMRKMGVDEALRKRGAKDGDLVRIMKFEFEFVE
>NC_006582.1|WP_011246396.1|1676336_1676711_-|hypothetical-protein
MKKLAGVVTACLLFFILTACGAQEDSGQEDNSTAESSETVVIKAMNWQFDKEEYAAGAGDVTVELKNEEGNHGIVIVGADNGSDLVISGSDSKTVTLEPGEYEIQCNIPCGPGHEEMVSTLVVS
>NC_006582.1|WP_011246397.1|1676864_1677383_+|intercompartmental-signaling-factor-BofC
MLKQVVHKHWLPFSLGAASFALLLGTFIILGEDASNDSPQVANPPNATEVLRETVFADGNIRTERVEETIWAIDDFWAEYEEWQLVDQSNHFVHFRKTILDLSPEVKEDGYLGIDADRGIVLYTGAQEAGQIVTRYSEIEAAKLSESDVAALEQGIRIESLEHLQNLLAQWR
>NC_006582.1|WP_011246398.1|1677513_1678113_+|Holliday-junction-branch-migration-protein-RuvA
MIDYIKGNLVAVEPAYLVVEANGIGFQIYCANPYRFINDLNREVVVPTHHYVREDSQRLFGFTTRTERLLFEKLLNVSGIGPKGALAILASGEPEDIIHAIEQEDEALLVRFPGVGKKTARQIILDLKGKLDDMAPMLEPAAGADKQQKNPQLEDALEALRALGYVEKELKKVEKQLKAETLETDEYIRRALALMLKRP
>NC_006582.1|WP_011246399.1|1678128_1679130_+|Holliday-junction-branch-migration-DNA-helicase-RuvB
MEERIVSAEATELEEQSEQGLRPKRLADYIGQETVKHNLAVFMEAAKMREEALDHVLLYGPPGLGKTTLAAIIAAEMGGELRTTSGPAIERSGDLAAILTALEPGDVLFIDEIHRLNRTVEEVLYPAMEDFCLDIVIGKGPTARSVRLDLPPFTLVGATTRAGMLSSPLRDRFGVMARLEYYKPEELAQIVERSATVFQATLEPSAALELARRSRGTPRIANRLLRRVRDFAQVGGEAAISLERACSALEQLHVDPLGLDHIDDKLLKGMIEKFNGGPVGLETIAATIGEEAATIEEVYEPYLLQIGFIQRTPRGRIATPACYAHYGVEKQNG
>NC_006582.1|WP_011246400.1|1679122_1679326_+|DUF2905-domain-containing-protein
MGKTLMVIGAVLLIVGFLWQVLGRFLPIGKLPGDFLFKSGQTTVYFPIMTCIIISIVLSLLFSLFRR
>NC_006582.1|WP_011246401.1|1679404_1680433_+|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA
MDVNEFDFDLPEELIAQTPLKTRTNSRLLVVDKKTKAISDRMFPDLIEALSPGDCLVLNDTKVMPARLLGEKVETKAVIELLLLKQLEGDCWETLVKPAKRVKIGTEVSFGDGKLTAICTAVQPQGGRIFEFRYSGVFYELLEELGTMPLPPYIKERLEDADRYQTVYAKQIGSAAAPTAGLHFSEQLLLEIEAKGVKIVYITLHVGLGTFRPVSASSVEDHQMHAEYYQVTEEAAHTLASARENGGNIIAVGTTSARTLETIYSDHGAFVAASGWTSIFIYPGYKYQAIDGLLTNFHLPKSTLVMLVSALIGKEALMDAYAHAIKERYRFFSFGDAMFIRP
>NC_006582.1|WP_011246402.1|1680446_1681598_+|tRNA-guanosine(34)-transglycosylase-Tgt
MTAAITYEHIKTCKQSGARLGRVHTPHGTIETPMFMPVGTLATVKTMSPEDLKAMDAQIILSNTYHLWLRPGEEIIKEAGGLHQFMNWDKPILTDSGGFQVFSLSDLRKITEEGVHFRNHLSGEKLFLSPEKAMQIQHVLGSDIMMAFDECPPYPADHSYMKASVERTSRWAERCLAEHKRSGKDSVQGLFGIIQGGEYEDLRKQSANDLTALDFPGYAVGGLSVGEPKDVMNHVLEFTTPLMPEDKPRYLMGVGSPDSLIDGAIRGIDMFDCVLPTRIARNGTCMTSAGRLVVRNAKYARDFSPLDEKCDCHVCRTYSRAYIRHLIKCEETFGFRLTTYHNLYFLLNLMKQVRQAIMDDCLLDFREQFFEEYGFNKENARNF
>NC_006582.1|WP_011246403.1|1681643_1681907_+|preprotein-translocase-subunit-YajC
MELLVSMLPFIAIIVLFYFLLIRPQQKQQKRVREMHANLQRGDKVITIGGLHGVIDSIDESVVVLLVNDNRKLTYDRNAIREVVQSD
>NC_006582.1|WP_011246404.1|1682014_1682395_-|TIGR04086-family-membrane-protein
MESRRFFPAVCIGTFVSICIAVAFSILMATLLYLTSLTEQSVHWVMVGCGFLALFVGGFFSGAKAKNKGWLAGAFTAFLFVAILLAISYLGYNESITSNQMLLFAGYCAIASLGGVFGVNFSGGNS
>NC_006582.1|WP_011246405.1|1682529_1682994_+|DUF421-domain-containing-protein
MDAMIVRAAATYAALVLIKQYKNETTQTQQGPFELALALFAGEAIAAFWSLWVLLPIFLLVIAAVLKRKTGESGKLQHTSKPPTVAPPLQKEGPALAMPLPLIIDGTIQHDHLRELRQTELWLRQQLRKLGYRDIKKIAYCSLKGKESFFIDSF

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Crispr_ID: NC_006582_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006582_2

3668449-3669271

Orphan

I-C

Consensus_repeat	Method
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CRT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CRISPRCasFinder
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	PILER-CR

12 spacers

The CRISPR arrays of NC_006582_2

>merge|NC_006582|2|3668449-3669271|CRT,CRISPRCasFinder,PILER-CR
CTCTTCATGTGTGCACGCATGAAGAGTGCGGCTACCAACGTTTGGCAGCTGAGAAGAGCGCGATTCATATCCACGCACTCACAAAGAGTGCTACCTCATGAAAGGCTCGGACGGCGGCGATGCATTTATTTCAATCCACGCACTCACAAAGAGTGCGACTTATTGTATCTCGAAAAAACCGCGGACTCATTTCCATTTCAATCCACGCACTCACAAAGAGTGCGACGGCCCATCGAGATACAGGCGCGAGTCATTGCGATTATTTCAATCCACGCACTCACAAAGAGTGCGACAAAGGAGCTGGTATAGATGGGGATTCCAGTAGAATTTCAATCCACGCACTCACAAAGAGTGCGACTTAAAAAGTTTGCTGGCTTCTTGCCAATTTCAAGCATTTCAATCCACGCACTCACAAAGAGTGCGACCTACCGTCTTGCTGTTTTTCCAATCCTGACTTTTATTTCAATCCACGCACTCACAAAGAGTGCGACTTAATAGATGCTTTAGTATAATTTGTACTTTTTATTTCAATCCACGCACTCACAAAGAGTGCGACTGAAGCGGCGCATCAGGCGTTATTAAAAGAGGCAAATTTCAATCCACGCACTCACAAAGAGTGCGACTTGATCGAACACTTGAGATATTTACGTTGGGTAGCTATTTCAATCCACGCACTCACAAAGAGTGCGACTCTGTGTATACTGAAATTCAACAAGCAAATTCTCATTTCAATCCACGCACTCACAAAGAGTGCGACAAGGCGATTGACTATTACCTGGGAGAGTCAACCGATTTCAATCCACGCACTCACAAAGAGTGCGAC

>NC_006582|2|1|3668449-3669271|CRT
CTCTTCATGTGTGCACGCATGAAGAGTGCGGC	TACCAACGTTTGGCAGCTGAGAAGAGCGCG
ATTCATATCCACGCACTCACAAAGAGTGCTAC	CTCATGAAAGGCTCGGACGGCGGCGATGCATTT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTATTGTATCTCGAAAAAACCGCGGACTCATTTCC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	GGCCCATCGAGATACAGGCGCGAGTCATTGCGATT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	AAAGGAGCTGGTATAGATGGGGATTCCAGTAGA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTAAAAAGTTTGCTGGCTTCTTGCCAATTTCAAGC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CTACCGTCTTGCTGTTTTTCCAATCCTGACTTTT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTAATAGATGCTTTAGTATAATTTGTACTTTTT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TGAAGCGGCGCATCAGGCGTTATTAAAAGAGGCAA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTGATCGAACACTTGAGATATTTACGTTGGGTAGCT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TCTGTGTATACTGAAATTCAACAAGCAAATTCTC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	AAGGCGATTGACTATTACCTGGGAGAGTCAACCG
ATTTCAATCCACGCACTCACAAAGAGTGCGAC

>NC_006582|2|2|3668511-3669271|CRISPRCasFinder
ATTCATATCCACGCACTCACAAAGAGTGCTAC	CTCATGAAAGGCTCGGACGGCGGCGATGCATTT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTATTGTATCTCGAAAAAACCGCGGACTCATTTCC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	GGCCCATCGAGATACAGGCGCGAGTCATTGCGATT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	AAAGGAGCTGGTATAGATGGGGATTCCAGTAGA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTAAAAAGTTTGCTGGCTTCTTGCCAATTTCAAGC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CTACCGTCTTGCTGTTTTTCCAATCCTGACTTTT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTAATAGATGCTTTAGTATAATTTGTACTTTTT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TGAAGCGGCGCATCAGGCGTTATTAAAAGAGGCAA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTGATCGAACACTTGAGATATTTACGTTGGGTAGCT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TCTGTGTATACTGAAATTCAACAAGCAAATTCTC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	AAGGCGATTGACTATTACCTGGGAGAGTCAACCG
ATTTCAATCCACGCACTCACAAAGAGTGCGAC

>NC_006582|2|1|3668576-3669271|PILER-CR
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTATTGTATCTCGAAAAAACCGCGGACTCATTTCC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	GGCCCATCGAGATACAGGCGCGAGTCATTGCGATT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	AAAGGAGCTGGTATAGATGGGGATTCCAGTAGA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTAAAAAGTTTGCTGGCTTCTTGCCAATTTCAAGC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CTACCGTCTTGCTGTTTTTCCAATCCTGACTTTT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTAATAGATGCTTTAGTATAATTTGTACTTTTT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TGAAGCGGCGCATCAGGCGTTATTAAAAGAGGCAA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTGATCGAACACTTGAGATATTTACGTTGGGTAGCT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TCTGTGTATACTGAAATTCAACAAGCAAATTCTC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	AAGGCGATTGACTATTACCTGGGAGAGTCAACCG
ATTTCAATCCACGCACTCACAAAGAGTGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_006582.1\|WP_041824123.1\|3672297_3673287_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224747
NC_006582.1\|WP_011248362.1\|3665756_3666311_+\|hypothetical-protein	unknown	unknown	unknown
NC_006582.1\|WP_011248369.1\|3673383_3674844_-\|sodium:solute-symporter-family-protein	unknown	unknown	gnl\|CDD\|271357
NC_006582.1\|WP_011248373.1\|3678983_3679481_+\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|341130
NC_006582.1\|WP_041824830.1\|3671241_3672132_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_006582.1\|WP_011248358.1\|3657725_3658985_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270376
NC_006582.1\|WP_035203351.1\|3655548_3656391_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226354
NC_006582.1\|WP_011248364.1\|3667476_3668286_-\|TrmB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224296
NC_006582.1\|WP_041824827.1\|3656390_3657629_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_006582.1\|WP_011248360.1\|3660491_3661937_+\|hypothetical-protein	unknown	unknown	unknown
NC_006582.1\|WP_011248361.1\|3661960_3665440_+\|hypothetical-protein	unknown	unknown	unknown
NC_006582.1\|WP_011248371.1\|3675603_3677358_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NC_006582.1\|WP_011248370.1\|3674860_3675607_-\|3-oxoacyl-ACP-reductase-FabG	unknown	unknown	gnl\|CDD\|235500
NC_006582.1\|WP_011248363.1\|3666530_3667397_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NC_006582.1\|WP_011248359.1\|3659173_3660166_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380486
NC_006582.1\|WP_041824126.1\|3679566_3680523_+\|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|366736
NC_006582.1\|WP_011248372.1\|3677623_3678820_-\|erythromycin-esterase-family-protein	unknown	unknown	gnl\|CDD\|350610
NC_006582.1\|WP_152024072.1\|3654325_3655387_-\|glycosyl-hydrolase-53-family-protein	unknown	unknown	gnl\|CDD\|226385
NC_006582.1\|WP_011248365.1\|3669458_3670118_-\|ABC-2-transporter-permease	unknown	unknown	gnl\|CDD\|379133
NC_006582.1\|WP_011248366.1\|3670114_3670972_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054

Protein	Function_ID	Function_description	E-value
NC_006582.1\|WP_041824126.1\|3679566_3680523_+\|aminoglycoside-phosphotransferase-family-protein	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	2.64529e-14
NC_006582.1\|WP_011248373.1\|3678983_3679481_+\|L,D-transpeptidase-family-protein	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	4.85685e-39
NC_006582.1\|WP_041824830.1\|3671241_3672132_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.35073e-35
NC_006582.1\|WP_011248358.1\|3657725_3658985_-\|extracellular-solute-binding-protein	gnl\|CDD\|270376	cd13658, PBP2_CMBP, The periplasmic binding component of ABC transport systems specific for cyclo/maltodextrin; possess the type 2 periplasmic binding fold. This group includes the periplasmic cyclo/maltodextrin-binding protein of Thermoactinomyces vulgaris ATP-binding cassette transporter and related proteins. Cyclodextrins are a family of compounds composed of glucose units connected by 1, 4 glycosidic linkages to form a series of oligosaccharide rings, and their cavity is hydrophibic which allows cyclodextrins to accomodate hydrophobic molecules/moieties in the cavity. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.54599e-144
NC_006582.1\|WP_035203351.1\|3655548_3656391_-\|sugar-ABC-transporter-permease	gnl\|CDD\|226354	COG3833, MalG, ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism].	7.83752e-127
NC_006582.1\|WP_011248364.1\|3667476_3668286_-\|TrmB-family-transcriptional-regulator	gnl\|CDD\|224296	COG1378, COG1378, Predicted transcriptional regulators [Transcription].	2.1466e-28
NC_006582.1\|WP_011248369.1\|3673383_3674844_-\|sodium:solute-symporter-family-protein	gnl\|CDD\|271357	cd10322, SLC5sbd, Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain. This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.	4.74921e-62
NC_006582.1\|WP_011248365.1\|3669458_3670118_-\|ABC-2-transporter-permease	gnl\|CDD\|379133	pfam13346, ABC2_membrane_5, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	2.17182e-26
NC_006582.1\|WP_011248371.1\|3675603_3677358_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	9.22117e-59
NC_006582.1\|WP_011248370.1\|3674860_3675607_-\|3-oxoacyl-ACP-reductase-FabG	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	2.65616e-92
NC_006582.1\|WP_011248363.1\|3666530_3667397_-\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.03897e-15
NC_006582.1\|WP_011248359.1\|3659173_3660166_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380486	cd01544, PBP1_GalR, ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism. Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism. Transcription of the galactose regulon genes is regulated by Gal iso-repressor (GalS) and Gal repressor (GalR) in different ways, but both repressors recognize the same DNA binding site in the absence of D-galactose. GalR is a dimeric protein like GalS and is exclusively involved in the regulation of galactose permease, the low-affinity galactose transporter. GalS is involved in regulating expression of the high-affinity galactose transporter encoded by the mgl operon. GalS and GalR are members of the LacI-GalR family of transcription regulators and both contain the type 1 periplasmic binding protein-like fold. Hence, they are structurally homologous to the periplasmic sugar binding of ABC-type transport systems.	1.11054e-101
NC_006582.1\|WP_152024072.1\|3654325_3655387_-\|glycosyl-hydrolase-53-family-protein	gnl\|CDD\|226385	COG3867, COG3867, Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism].	2.50031e-142
NC_006582.1\|WP_011248372.1\|3677623_3678820_-\|erythromycin-esterase-family-protein	gnl\|CDD\|350610	cd14728, Ere-like, Erythromycin esterase and succinoglycan biosynthesis related proteins. This group contains erythromycin esterase, which shares conserved active site residues of the Tiki/TraB family. Erythromycin esterases (EreA and EreB) disrupt erythromycin via the hydrolysis of the macrolactone ring. A critical catalytic histidine acts as a general base in the activation of a water molecule. Macrolides act by inhibiting bacterial protein synthesis by binding at the exit tunnel of ribosomal subunit 50s, blocking the translation of the polypeptide. Erythromycin esterase, typically found in integrons and transposons, confers antibiotic resistance through the disruption of the drug ring structure. EreB substrate profile is substantially broader than that for EreA, being able to also metabolize semisynthetic derivatives such as azalide azithromycin.	1.58672e-56
NC_006582.1\|WP_041824123.1\|3672297_3673287_+\|hypothetical-protein	gnl\|CDD\|224747	COG1834, COG1834, N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism].	1.02831e-45
NC_006582.1\|WP_041824827.1\|3656390_3657629_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.94775e-78
NC_006582.1\|WP_011248366.1\|3670114_3670972_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.61402e-70

>NC_006582.1|WP_011248364.1|3667476_3668286_-|TrmB-family-transcriptional-regulator
MEEAVIQELQKHGFSKYESKAYIGLLKAPAITGYELSKRSGVPRSMIYEVLGKLLDKGAVHTVPADPIVYKPVDPRQLLTKMREDLDASLTSLEDSLTTLESDQKIDVVTRIVQYDHIISEMRSMIRAAKKELWLSIWSPTVASIEDVLKEKETDIPIFTVLFGDESKSFGHTYHHNYMAPNIVSERMGGYLTIVIRDEEEALIAKFSDKGSEWAVKSMDPALVLIATEYIRHDIMVEEVTNAFGPEKLDALWRKREDLIHVMTGKSSL
>NC_006582.1|WP_011248363.1|3666530_3667397_-|DMT-family-transporter
MNAHVKFSLAMAIFGSIGLFSVKAGLPSLELVFVRCLCASVMLGAVLLLTNRKGREERPPKSEYGKVLLCGLFLVLNWLFFFRSFEVMPITVAVSIYHLAPLLILLLGSLLFKEKLTWAGIASIVICFVGALLVGKAYSHGHVSDFLQTGIGWAFAAAFFYALTSLAGKSITVLSPTKTTLIQTMLGAVLLAPLVDWHLFSGLSAENWLFILITGFIHTGVVFYFFFSSLRELPASTIAILVFIDPIVAILLDVAVLHYRPDILQLVGILLIFLAMGYRPKKYEQKKA
>NC_006582.1|WP_011248362.1|3665756_3666311_+|hypothetical-protein
MNYKELDARSKHLKPVKLNRFQIEHTLERKYEAKELPLFTIPRKDYENDEEVDEKRIYKLYTITNKQVLKQIQNKDDIDAIKEPFLSTIYEKASYIVSQTKSKNDGQSVSYNQLIHEHNHGKRVSVVLEKDETDYVTNFKVYGFAHHLVTYLVARIGIEGMKEGDMTDTDYQFYLECLAENGFI
>NC_006582.1|WP_011248361.1|3661960_3665440_+|hypothetical-protein
MGVSRYSIQSTLMKSYVSGTPLQYDKALTTTTGTDGQLWLFSIGSDGLIYLYSKENGTDKGWNTRYLSGGLPKHSEAVFIEAIQDADGAPLLTAVVLKEQTYTVYMTKDFSDHTKDRWLFRGQYSGGTVSNIATGYGKQGQVFIVVTTQDKDRSSNHLINPNLTDTTWLWREVPAPLNSKHVIQTAIGHHNKLESINGVDGLLYALYQTSDKQTQLVITSLPDFHYYNHPVPLDFSPTSFALVTAPGSNSECWLGDTSVYYASPAVQLAKDAKTVKAGLRKIDGNPSKRPYKQILAARTNSGTDIWLLTDDGKLSRSYFDETSWTEPLLFQEQVGESALWVNRTTGENHLVVVDLDNQLYRYFQDVSTTRWHSEQILFESLGTIEEKDGYSTVIQLVDDKGAPAVNETIWVQASELVQLTINGKTYFATDRPGYIEANTDSLGNVMITQYVKSVAAAALRITIPALNETIDIEPLAQVKQKLTGMTVDEWINAEMQTDQDGVTEPLLKGKSKQDIADTHQAVQRLLTMAQTLPSHKQGPFQTSSKHIPLANTLSLAHVEDGMHWGLDLTGKHPVYTENKGHIDQHFNPRAHLLNQTKDTAHILSDWFGDIWHAIKQGFITVTHFVFSKVKEGIELVINSAEKAYRVVLRYAEQLWDVIEYVFAEIDILLDDFVRWLGYLFKWKDILRTHEVIRTTVELGIKETVQKLDQGKAFVDRLIEHVQRNIADPALQENIGAFGSRTLTEQEYGQQLLFEAPEANWSMNYVMSGHLLKPGGNLPEVDTLAYDESWGAGLESVKQQFEQFGTELASQFESWSFATLFQKIISLLEDAVLEGVKLLADGLFTAAEQITQMVDDLLHIHWNVPLLTPLYEEIVAPGSKLTLIDFISLLTAIPATVLYKATTGDVPFEEETTTQLVNSQSYGDFLAKLGGKQPHLALDQEQSPVLLQAAAEPEVPIAARKASYAFGFIGGIASIIAGTASTTMSFTETTTIGCAVVFLSYSVGTATSVTTLSLDLAYKPYEKRLGFEMFYALFQIGFNLKDGLALGNQIKNKGIAKLAYELLLDLGETLLGAISCAFSIALAIWEGVDGEMTTSNGMKLTQNLAITISQILAFPASVISEPRVKKVIQGAQAFCNISPGVIDICRTAYDQEMEAIHTNR
>NC_006582.1|WP_011248360.1|3660491_3661937_+|hypothetical-protein
MLTYQNLNGFDMVYAVSQQTINAQLQLLWAMDMLPTTWKAEAAEGLYSIDAELGCPVVDFNTGDSSSRTAKLTMPLTKASFHYAKIVIEDGKPTVVQTTKEINGSSLSFFVNMSLAELASTYQNQDSIPDEVKRQLEQFDTSMFSIQHLFLNFEDAHLLKSFDFQTNGAIPTDQPELTGQIRNLVEAFIDTIKGNDNPYIFGYYAVDKISEPSQATWQPTGCTYSIYSDAHFASRSSINYLLVTDHKTVPGSGAGMFQHNWVMSDQVEGSFVLSQALVMDPLLQSLANMLSIDKTQFSPTNNNQFFVSFESRLDKNTKGKTTCTLVPLVGTKQMAVYFNIDYNTDMHDLAGSYIGYVDGTIKWTTTLTFEVDTIKSSVNVSAKNSEVITTKKDHPNALGKFEHALAVFADFIITVFTFGQVDDVFQDLIRKDWQKTINTGYSTQMNSMKARAILPGGSEIMFKDAQFYENGSMIVATTVKN
>NC_006582.1|WP_011248359.1|3659173_3660166_-|LacI-family-DNA-binding-transcriptional-regulator
MATIKEIAEKAGVSITTVSRVLKQDPTLSVTQETREKVYETAQRLGYTKKRFKHSLKKIAFLYWITEKEDLQDVYFQTVKKGVEEEANERQLNLTTYSIGDGIEAIDPQTKGVICLGRFSKRELDYIRTLTNDVVFIDTSPDEDHFDSVRPHLRRMIERMIDYYLENGHTAIGYIGGNDFDADCGGYIPDRRERAFKEYMEKKGLFDERFLFVGDQYAVNEGYALMKRAIHSLGDQLPTAFCVASDSLAVGCLQALNEERIALPERVNVFSINDASIAQYVSPPLTTFRIDVKLLCQTAIDLLLERLVDKRTSPKTVLMSCNPIFRKSTG
>NC_006582.1|WP_011248358.1|3657725_3658985_-|extracellular-solute-binding-protein
MKTNWRMVLLSGAVLTVVACGPQEDGDAGESASGTSADKLVIWEDAEKAIGIEKAVAAFEDMHGIEIEVIEKEYGGQLEDLRLDGPAGSGPDVLTIPHDQIGTAVVEGLLAPLEVDDEVTGRFTEESLLSQTVDGEVYGLPKAVETTILFYNKELVDEPPQTLDEWYELSKERVAEDEYGFVAKWDEIYYAMSVIGGGGGYIFPQNEDGQYDVNDIGLANEGAIEGGTYIQTFFEEGLFPAGIVGEQGINVLDSLFTEGKAAAVISGPWSFEPYARAGIDYGVLPLPALADGEPMSSFLGVKSYNVSSYSQNAELAQEFVEFLTNEENSLDRFEQTREIPPLTSLVEHPAIAEDEHAAAVSEQSLYATMTPNNPEMAEVWTPIDNALGLIATGRTDVQEALEEAVQTIESQIEANHSQN
>NC_006582.1|WP_041824827.1|3656390_3657629_-|sugar-ABC-transporter-permease
MLAIIPGMGQMYNKQFAKGTLFFLFGAAFLFVFKDIFNMGFWGLATLGVQTPRDNSVFLLAEGIIAVIVAAFGLAFYYFMIKDAAKNGKRRDLGLELHSIRRQYHHLLDASFPYLMSSPAFFLLIFTVIFPILFSLAIAFTNYDLYHSPPANLFDWVGLKNFRDIFSVPIWRSTFLDVLGWTVVWTLVATTLQCALGIFLAILLNQRDVRGKAFFRTFFILPWAVPGFVTILVFAGLFNDSFGAINNHILTFFGVDGLPWLNDPFWSRVALIVMQMWLGFPFVFIMTTGVLQAIPNDLYEAATIDGAGFIQKFRLITLPLVLYSIAPILITQYTFNFNNFNIIYLFNGGGPPMPGSTAGGTDILVSWIYKLTMQSSQYALAAAITMLLSIFVISIALWQFKRTNSFKEEDMM
>NC_006582.1|WP_035203351.1|3655548_3656391_-|sugar-ABC-transporter-permease
MTVYTKRRIRLFVTYSILVSVVLVIAYPLVWTIGASFNPGNSLMSTSMIPENPTLAHYIHLLGEGSHPYVQWYLNSLKISLLTMGITLVLVSFSGYAFSRFRFKGRKNGLMLFLLLQMIPQFSALIAIFVLAQMLGLINSHWALVLIYAGGQIPMNTFLLKGYLDSIPRDLDESARMDGASHFRIYGQIIMPLAKPILAVVAINSFTGPLGDFILASVIVRSPEMYTLPIGLYNLVSNPMGASYTMFAAGALLISIPVALMFLLLQKQFVSGLTQGGVKG
>NC_006582.1|WP_152024072.1|3654325_3655387_-|glycosyl-hydrolase-53-family-protein
MLPEIEENGGRYYADGEQIDPLVLLKEKGVNAVRIRIWVDPYDENGNPYGGGTVGEQRAVDLAKRAHNHGFQLLLDFHYSDFWTDPGKQFKPKSWEHYSFEELKSAIYHHTSNVLGQLKDAGIIPEMVQVGNEINAGMLWPDGKSWGEGGGEFDRLAALLKAGLTAVKDCDPGIRTMLHLAEGGDIDMAQWWLDEIVKRDVDFDVVGLSYYPYWDGDFSKLKQVMELVTNDYGKGVNVVETAYGFTTDNGDNLDNIFSSEYAQLVGYPASPQGQASYLRDLMETIHAVGGEGFYYWEPLWIPVSGASWANEAGMRYIQTEGEVGNAWDNQAMFDFNGEALPSLDVFHLVNQLK
>NC_006582.1|WP_011248365.1|3669458_3670118_-|ABC-2-transporter-permease
MKGLILNQYYSVGKSFWNYIALSVVITAILLFTQNEMLMQFAAWLPLFFMVTPALEVLKHESMSGWSKFVLTLPLKRREVVQSHYLFYSMMIVIGIVITVALFMVADSLIGQVMTDSAVNKIMNGVGIVLISGLLNYPLTYLLGTEKSDGILVFSIMAAVGLFLLSSWLFEIFLGAVSFDALQGMNLDKLFSGSFLAVTFVLFMASYVIALQVYKRKEF
>NC_006582.1|WP_011248366.1|3670114_3670972_-|ABC-transporter-ATP-binding-protein
MSFILEVDNLRKQYSDSAFALKGVSFSIPYGSIVGFIGENGAGKSTTMGSILGTLQKDSGTIHIFGEEMAPDKLHLKENIGVVFDDIKLPGDLNIVKLGNVFQRIYKQWNQKTFDRYVDFFSLPRNKKIRGFSRGMSMKLSAAVALSHDAKLLILDEATAGLDPTGRDELLDVLKGFVQDGKRGILLSSHITSDIEKIADSLVFIKNGKILLNVKKAELREKYAILQCRQNEFDLIQQKLILTYKKNEDTVDVLVSDREQVPSSIAKKDFTIDDMTLLLMRGETA
>NC_006582.1|WP_041824830.1|3671241_3672132_-|helix-turn-helix-transcriptional-regulator
MDYNKSIQTSIAYIESHLQDPISVADVAKKAGYSPYHFHRVFLQEVGLSLSEYIKRRRLCFAAKTLLHTDTPVIEVAFTCGFESQEAFTRAFKRLYGLPPARYRTRFQPHQFIQANGGNMMDLQTSPIKHWFLSGSQPAEYEYGLDTETVHQGSVSAYLKSYALQEEDDFATLMQQFNAKNYVGKRVRFSGFVKTKNVTNYCGLWMRVDNNMNDALQFDNMSNRKIVGTTNWNRYAIVLDVPENSAVISFGLLLSGKGQAWLDSCSFEVVDKKLPSTNIEMNFTMYDEPLNLSFQE
>NC_006582.1|WP_041824123.1|3672297_3673287_+|hypothetical-protein
MPLPSNHLPGQRLVVDSFYDIDAQQAVWGGLWGAFSPVGPIQKVLIHRPGNELRQLDNKSYETYIDDQILQDNQGVIGNDLTGTDPIDVALLHRQHDQLRQALLDSGAEVIDLDFVSPNHPKSIYVHDLGLVVPGGVILPRLALGIRQGEEQAAYRTFAKLGMPVLATIQGNGFIEGGSFTMLDERSAVVGRSVRVNQAGIDQLRTILAWQEMELIVVDLPADRIHLDELFMLVDTKTALVEPKRLPYWFLKELRSRGYRLIYTDPNDPDRAANCLTLAPGHVLIASEYPGTIKQLQQAGIRTKTIDTTEIRKIGGGIHCAALPLVRGQ
>NC_006582.1|WP_011248369.1|3673383_3674844_-|sodium:solute-symporter-family-protein
MEGIIIFLIYLVFIYYMGYKGYQRVQTAEDLIVAGWSMPLYVVTGSLVAALLAAPFFFAAVGSGYTSGGFEGTATMAGLGTCMILGALIWTRPLRRLRGWTIADYYGLRFASKKLGAYTGSVMAVAFGFFNAGALTVGGTYVIQTIFAIDFIPAACLFVLLTVVYSAIGGLWAVAYTEIVQGVVALIGILGIAGVVLFTHGDLTFQPDWWNVSNLFEKGGVEFWALYLVLALGDIPAADLGQRVAGAKSPRVAYLSMIIAGVIVISISWIPGMLGEAFKTIFPNSDNPEMLMIMFADGYFPPIISAIFLTSLAAMGMSTLAACYVASAGIWTKNIYLDLINDQPDPKKLLLFSRIAICVSAALGLLLALGFQKVIDLAYLAWDVVFVTLFWPIVLAPFWGRVSTKAVWASVTLGLLSYGVTTFTGVPGPEVASTGIIGLLVELWHLPVFFGVVISGLTIVITSLVSPATPEVRNMHELEKIPTADE
>NC_006582.1|WP_011248370.1|3674860_3675607_-|3-oxoacyl-ACP-reductase-FabG
MNALKGKTAVVTGASKGIGRAVALELAKAGADVLVNFIGNPEEAEEVCAIAASYGVRAMKWQADVSDPQQVRDMYALVDREFGKIDILVNNAGIAEEAPIIDMTDEGWDRMIRVHLYGTFHNCREAAKRMTEAKAGKIINISSDLGHLGCENFSHYSAAKGAINAFTKSLARELAPHVLVNAVAPGGTWTDILASFGDDYAEEEAQKYPLKRLAKPEEIAKSVLFLASDDANFYTGQILGPNGGAVMP
>NC_006582.1|WP_011248371.1|3675603_3677358_-|methyl-accepting-chemotaxis-protein
MERISQLSLRHKLAIPIVALVIICFVILTWMSQSTLSDQLHRDLERELRSVGLLTASSLDPSDVEAVMGVTDETDEAFVHLQNQLETIMEKQGIMYWSYIWQMEGDSVIPLGFTKNLEDVYNVGESFDNLASIHIEGGHQAIESGEPVVTDVFEDDFGTWSTVFSPIENEHGETVAVIGIDYSAEYIDSILGELQLSQWLTAIMGTLIVACFVYFVVNGLLKPLKQVVQVTNKVADGDLAVPSLEVRSKDEVGQMATALNQMVQSLRALIQNMAYASEQVAASSQQVAAASNQTEQAANEVVAVMGDMAEGARVSQQAAEDTAKATEENAQGIQRIAQSSAVVAESAQKTAAEASQGNDIIQNVVKQMQSVSSSVNQAGKEVQELGERSSEIGKIVELITNIANQTNLLALNASIEAARAGENGRGFAVVAGEVGKLAEQSAASAKQITDIIAEIQTVTERSVESMATGTKDAEEGLASVNEAGEVFQRILGAAQQVAAQVEEVSSVSEQLSANSEEVAASVQELTGFAEETTNRTDNVTTVSKEQLAAMKEIAASSDSLTQMAEQLQESMNQFKLEQQKDVLE
>NC_006582.1|WP_011248372.1|3677623_3678820_-|erythromycin-esterase-family-protein
MVNKFADRRPDWIEQINEQLIPLDEGEWKQLDRFLEGKQIVLLGENSHWVSEYYTNKIKLVQYLHEKHGFRVLVLESGLVEASTTDFFGNTNLEYAMKNGLLGIYHNEEMAALFTNEGLKDLMIAGMDVQPISNDCSQRILSCVEKEIGGHVANKLKDVEATFFELEPQIRNEVKLAKDTKKQLKQLAEGYEEVISLMENEMQAGVYSKRLQLIYRGIVNRKQWLLVNLKGRFRSGSLRDVFMYENLEWLFDYYKGEKIIVWSHNYHIRKNRSLLLKGLGIKTVGHLLAKQYAHSLLSVSFYAGSGTCLSPYKQPYDISIKNQYHLEKLLMEFNRDVLFLPVNVDAIGKKRPWSKQNWWLLEMKWLGMAPLVIKPYKFYNAIFFVKRVNPPRYLEDQD
>NC_006582.1|WP_011248373.1|3678983_3679481_+|L,D-transpeptidase-family-protein
MFFHSVQQGETLSSIAADYRISLSHLIQANPTINPNQLFVGQSIVIPGLPNPNTIPYEIHVSLSQHQLTLLHNGSVVKIYPIAVGKMLTQTPTGNFVIVNKAPNPGGPFGTMWMSLSKLHYGIHGTNDPSSIGKSVSHGCIRMHNKDVEELAATVPIGTRVRIEP
>NC_006582.1|WP_041824126.1|3679566_3680523_+|aminoglycoside-phosphotransferase-family-protein
MDSLKQLLQEQYQLQAQTISPQKGGWAALAYRVETKKHTYFLKMYEKSRTSTPKWTALIDEYVPALIWLNEQNDLNGKVPVPILTKNGQCKCENDKGIFLLYEHIEGETIGPQQLTNDQVEQLATIIAALHAIGEETAPIATAQLKEDFSLPFAVSLYKLLTEQLATLPDDIQTTIAPFSQPLLSLIESTEKRANTLKQRPLRYALCHTDLHHWNLMTSQGELVLIDWEGLKLAPVEADMMFVVDECYNNAFMDHYRKRHLDYVIDQECLAFYQGRRKLEDIWEFLEQLLFDEQKPTERAAILEGLEKELEAVAKACL

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Crispr_ID: NC_006582_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006582_3

3720845-3721873

Orphan

I-C

Consensus_repeat	Method
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	PILER-CR
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CRISPRCasFinder
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CRT

15 spacers

The CRISPR arrays of NC_006582_3

>merge|NC_006582|3|3720845-3721873|PILER-CR,CRISPRCasFinder,CRT
ATTTCAATCCACGCACTCACAAAGAGTGCGACGCCGCCTTTTTTTGCCCGTTTACGGGAAATGCAAATTTCAATCCACGCACTCACCAAAGAGTGCGACATTTGAAGGTTATTTGAACCAAAAAGGAGCTGTATTTCAATCCACGCACTCACAAAGAGTGCGACACCAATGTATTTGTATTTTGGCACCGTGATAGTGATTTCAATCCACGCACTCACAAAGAGTGCGACATTGCATTTGATGCTTGGATTGCAGCGCTCGCTTTTATTTCAATCCACGCACTCACAAAGAGTGCGACATTGGTTTAAGTTGCAGCCGGGTGTCAATAGGTTATTTCAATCCACGCACTCACAAAGAGTGCGACAAAACAAGAATTGTCTGAGTGGTTAGTCCACGACATTTCAATCCACGCACTCACAAAGAGTGCGACACAAACGGTGGTGAAAACCCTATGAACACACAAATTTCAATCCACGCACTCACAAAGAGTGCGACAAGAAGCAATCAAAGGCTTAGTCAAAGGAATGCAAATTTCAATCCACGCACTCACAAAGAGTGCGACACTAAAAGTTAAAATATGGAAGGTGATAAAAATGAATTTCAATCCACGCACTCACAAAGAGTGCGACTATAGTCGTTTTGGATATGCCGATTCTAGATACTAATTTCAATCCACGCACTCACAAAGAGTGCGACCAACAAAGAAAAATAGAAAAACTATGGAAATGTCTATTTCAATCCACGCACTCACAAAGAGTGCGACTCTGCGGCGACTGAACAAGTACCTTGGATTTTTAATTTCAATCCACGCACTCACAAAGAGTGCGACTTCAAATTCCCGCGCTGTAAAGGAGCCTACTACCTGATTTCAATCCACGCACTCACAAAGAGTGCGACGCTTGATTTTAGATTTACATTTGAGGTGACAGACTATTTCAATCCACGCACTCACAAAGAGTGCGACCCTCGGCATTTACATCAGCGACAAAACATCCGCATTTCAATCCACGCACTCACAAAGAGTGCGAC

>NC_006582|3|2|3720845-3721873|PILER-CR
ATTTCAATCCACGCACTCACAAAGAGTGCGACG	CCGCCTTTTTTTGCCCGTTTACGGGAAATGCAAA
TTTCAATCCACGCACTCACCAAAGAGTGCGACA	TTTGAAGGTTATTTGAACCAAAAAGGAGCTGTA
TTTCAATCCACGCACTCACAAAGAGTGCGACAC	CAATGTATTTGTATTTTGGCACCGTGATAGTGAT
TTCAATCCACGCACTCACAAAGAGTGCGACATT	GCATTTGATGCTTGGATTGCAGCGCTCGCTTTTATT
TCAATCCACGCACTCACAAAGAGTGCGACATTG	GTTTAAGTTGCAGCCGGGTGTCAATAGGTTATTT
CAATCCACGCACTCACAAAGAGTGCGACAAAAC	AAGAATTGTCTGAGTGGTTAGTCCACGACATTTC
AATCCACGCACTCACAAAGAGTGCGACACAAAC	GGTGGTGAAAACCCTATGAACACACAAATTTCA
ATCCACGCACTCACAAAGAGTGCGACAAGAAGC	AATCAAAGGCTTAGTCAAAGGAATGCAAATTTCAA
TCCACGCACTCACAAAGAGTGCGACACTAAAAG	TTAAAATATGGAAGGTGATAAAAATGAATTTCAAT
CCACGCACTCACAAAGAGTGCGACTATAGTCGT	TTTGGATATGCCGATTCTAGATACTAATTTCAATC
CACGCACTCACAAAGAGTGCGACCAACAAAGAA	AAATAGAAAAACTATGGAAATGTCTATTTCAATCC
ACGCACTCACAAAGAGTGCGACTCTGCGGCGAC	TGAACAAGTACCTTGGATTTTTAATTTCAATCCA
CGCACTCACAAAGAGTGCGACTTCAAATTCCCG	CGCTGTAAAGGAGCCTACTACCTGATTTCAATCCAC
GCACTCACAAAGAGTGCGACGCTTGATTTTAGA	TTTACATTTGAGGTGACAGACTATTTCAATCCACG
CACTCACAAAGAGTGCGACCCTCGGCATTTACA	TCAGCGACAAAACATCCGCATTTCAATCCACGC
ACTCACAAAGAGTGCGAC

>NC_006582|3|3|3720845-3721873|CRISPRCasFinder
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	GCCGCCTTTTTTTGCCCGTTTACGGGAAATGCAA
ATTTCAATCCACGCACTCACCAAAGAGTGCGA	CATTTGAAGGTTATTTGAACCAAAAAGGAGCTGT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	ACCAATGTATTTGTATTTTGGCACCGTGATAGTG
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	ATTGCATTTGATGCTTGGATTGCAGCGCTCGCTTTT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	ATTGGTTTAAGTTGCAGCCGGGTGTCAATAGGTT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	AAAACAAGAATTGTCTGAGTGGTTAGTCCACGAC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	ACAAACGGTGGTGAAAACCCTATGAACACACAA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	AAGAAGCAATCAAAGGCTTAGTCAAAGGAATGCAA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	ACTAAAAGTTAAAATATGGAAGGTGATAAAAATGA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TATAGTCGTTTTGGATATGCCGATTCTAGATACTA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CAACAAAGAAAAATAGAAAAACTATGGAAATGTCT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TCTGCGGCGACTGAACAAGTACCTTGGATTTTTA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTCAAATTCCCGCGCTGTAAAGGAGCCTACTACCTG
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	GCTTGATTTTAGATTTACATTTGAGGTGACAGACT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CCTCGGCATTTACATCAGCGACAAAACATCCGC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC

>NC_006582|3|2|3720845-3721873|CRT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	GCCGCCTTTTTTTGCCCGTTTACGGGAAATGCAA
ATTTCAATCCACGCACTCACCAAAGAGTGCGA	CATTTGAAGGTTATTTGAACCAAAAAGGAGCTGT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	ACCAATGTATTTGTATTTTGGCACCGTGATAGTG
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	ATTGCATTTGATGCTTGGATTGCAGCGCTCGCTTTT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	ATTGGTTTAAGTTGCAGCCGGGTGTCAATAGGTT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	AAAACAAGAATTGTCTGAGTGGTTAGTCCACGAC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	ACAAACGGTGGTGAAAACCCTATGAACACACAA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	AAGAAGCAATCAAAGGCTTAGTCAAAGGAATGCAA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	ACTAAAAGTTAAAATATGGAAGGTGATAAAAATGA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TATAGTCGTTTTGGATATGCCGATTCTAGATACTA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CAACAAAGAAAAATAGAAAAACTATGGAAATGTCT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TCTGCGGCGACTGAACAAGTACCTTGGATTTTTA
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	TTCAAATTCCCGCGCTGTAAAGGAGCCTACTACCTG
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	GCTTGATTTTAGATTTACATTTGAGGTGACAGACT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CCTCGGCATTTACATCAGCGACAAAACATCCGC
ATTTCAATCCACGCACTCACAAAGAGTGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_006582.1\|WP_011248412.1\|3719688_3720633_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238570
NC_006582.1\|WP_011248416.1\|3724190_3724676_-\|DUF1648-domain-containing-protein	unknown	unknown	gnl\|CDD\|377929
NC_006582.1\|WP_011248417.1\|3724804_3725563_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NC_006582.1\|WP_011248407.1\|3715516_3716575_-\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NC_006582.1\|WP_050749064.1\|3722154_3722622_-\|HXXEE-domain-containing-protein	unknown	unknown	gnl\|CDD\|379370
NC_006582.1\|WP_011248410.1\|3718245_3718725_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
NC_006582.1\|WP_011248421.1\|3731321_3732155_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_006582.1\|WP_011248411.1\|3718717_3719506_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_006582.1\|WP_011248406.1\|3714646_3715516_-\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|376459
NC_006582.1\|WP_011248408.1\|3716595_3717942_-\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NC_006582.1\|WP_011248414.1\|3722718_3723453_-\|SMI1/KNR4-family-protein	unknown	unknown	gnl\|CDD\|378155
NC_006582.1\|WP_011248420.1\|3729930_3731295_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NC_006582.1\|WP_011248409.1\|3717967_3718243_-\|PTS-galactitol-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NC_006582.1\|WP_011248404.1\|3712378_3713806_-\|collagen-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|227268
NC_006582.1\|WP_142301323.1\|3732144_3733017_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NC_006582.1\|WP_041824836.1\|3723521_3723995_-\|DUF5381-family-protein	unknown	unknown	gnl\|CDD\|375146
NC_006582.1\|WP_011248419.1\|3727317_3728643_+\|6-phospho-alpha-glucosidase	unknown	unknown	gnl\|CDD\|133434
NC_006582.1\|WP_011248403.1\|3711771_3712362_-\|class-D-sortase	unknown	unknown	gnl\|CDD\|320681
NC_006582.1\|WP_011248418.1\|3725707_3727291_+\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273925
NC_006582.1\|WP_011248401.1\|3711125_3711464_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045

Protein	Function_ID	Function_description	E-value
NC_006582.1\|WP_011248412.1\|3719688_3720633_+\|hypothetical-protein	gnl\|CDD\|238570	cd01164, FruK_PfkB_like, 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.	9.9041e-65
NC_006582.1\|WP_011248416.1\|3724190_3724676_-\|DUF1648-domain-containing-protein	gnl\|CDD\|377929	pfam07853, DUF1648, Protein of unknown function (DUF1648). Members of this family are hypothetical proteins expressed by either bacterial or archaeal species. Some of these are annotated as being transmembrane proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues.	0.00239141
NC_006582.1\|WP_011248417.1\|3724804_3725563_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	8.9767e-36
NC_006582.1\|WP_011248407.1\|3715516_3716575_-\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	1.86586e-166
NC_006582.1\|WP_050749064.1\|3722154_3722622_-\|HXXEE-domain-containing-protein	gnl\|CDD\|379370	pfam13787, HXXEE, Protein of unknown function with HXXEE motif. This domain contains an HXXEE motif, another conserved histidine and a YXPG motif. Its function is unknown.	8.61486e-15
NC_006582.1\|WP_011248410.1\|3718245_3718725_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	2.57201e-35
NC_006582.1\|WP_011248421.1\|3731321_3732155_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.45871e-90
NC_006582.1\|WP_011248411.1\|3718717_3719506_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	4.3258e-90
NC_006582.1\|WP_011248406.1\|3714646_3715516_-\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|376459	pfam01116, F_bP_aldolase, Fructose-bisphosphate aldolase class-II.	1.88261e-129
NC_006582.1\|WP_011248408.1\|3716595_3717942_-\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	4.91628e-164
NC_006582.1\|WP_011248414.1\|3722718_3723453_-\|SMI1/KNR4-family-protein	gnl\|CDD\|378155	pfam09346, SMI1_KNR4, SMI1 / KNR4 family (SUKH-1). Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.	5.58852e-06
NC_006582.1\|WP_011248420.1\|3729930_3731295_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	2.05904e-149
NC_006582.1\|WP_011248409.1\|3717967_3718243_-\|PTS-galactitol-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	1.29288e-38
NC_006582.1\|WP_011248404.1\|3712378_3713806_-\|collagen-binding-domain-containing-protein	gnl\|CDD\|227268	COG4932, COG4932, Predicted outer membrane protein [Cell envelope biogenesis, outer membrane].	1.84695e-133
NC_006582.1\|WP_142301323.1\|3732144_3733017_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.06172e-89
NC_006582.1\|WP_041824836.1\|3723521_3723995_-\|DUF5381-family-protein	gnl\|CDD\|375146	pfam17353, DUF5381, Family of unknown function (DUF5381). This is a family of unknown function found in Bacillales.	0.00404155
NC_006582.1\|WP_011248419.1\|3727317_3728643_+\|6-phospho-alpha-glucosidase	gnl\|CDD\|133434	cd05298, GH4_GlvA_pagL_like, Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases. Bacillus subtilis GlvA and Clostridium acetobutylicum pagL are 6-phospho-alpha-glucosidase, catalyzing the hydrolysis of alpha-glucopyranoside bonds to release glucose from oligosaccharides. The substrate specificities of other members of this subgroup are unknown. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP_PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases, which include 6-phospho-beta-glucosidases, 6-phospho-alpha-glucosidases, alpha-glucosidases/alpha-glucuronidases (only from Thermotoga), and alpha-galactosidases. Members of this subfamily are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NC_006582.1\|WP_011248403.1\|3711771_3712362_-\|class-D-sortase	gnl\|CDD\|320681	cd06166, Sortase_D_2, Sortase domain found in subfamily 2 of the class D family of sortases. Class D sortases are cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). They anchor surface proteins bearing a cell wall sorting signal to peptidoglycans of the bacterial cell wall envelope, which is responsible for spore formation under anaerobic conditions. This involves a transpeptidation reaction in which the surface protein substrate is cleaved at the cell wall sorting signal and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical subfamily 2 of class D sortase from Clostridium perfringens (named Cp-SrtD) recognizes the LPQTGS signal motif for transpeptidation. Its catalytic activity is in a metal cation- and temperature- dependent manner. The presence of magnesium appears to enhance Cp-SrtD catalysis towards the LPQTGS signal motif.	2.16901e-46
NC_006582.1\|WP_011248418.1\|3725707_3727291_+\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273925	TIGR02005, PTS-IIBC-alpha, PTS system, alpha-glucoside-specific IIBC component. This model represents a family of fused PTS enzyme II B and C domains. A gene from Clostridium has been partially characterized as a maltose transporter, while genes from Fusobacterium and Klebsiella have been proposed to transport the five non-standard isomers of sucrose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NC_006582.1\|WP_011248401.1\|3711125_3711464_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.27383e-14

>NC_006582.1|WP_011248412.1|3719688_3720633_+|hypothetical-protein
MIHILCANPALDRTIYVQAFYPNGVTRSSASHEGLGGKGFNVALPFIVTNEQKTIHMHTFFGGPVGEQLAQMMKNAQLAGETTFIEGDNRYCTILVNESKQEAALINEQGPSITEKEQQQFLQSLFCSLKAGDHLVLSGSLPKGTPLTFYRDIIAQAESRGVQTILDSSGDALAYGAEAKPWLIKINGEEFLDLMGVKEEAANRQQQIEESLKNSPYPNCIVTLGGEGTVAKINGDIWRVTLPTINVTNATASGDIFLGTFIREWRKTNDVKAALLAGSALSLANCLHWLPTIDFSQAEQYQQKIHIERIGSAV
>NC_006582.1|WP_011248411.1|3718717_3719506_-|DeoR/GlpR-transcriptional-regulator
MLPQERQDLIMKELYEYHSVKISELSSKLDVTRETIRKDLYELEEKGLIRKVHGGAVLNKANLETNYSSRKIVNEWEKRAIAKKAVEFVFDNDTIYIDYGTTALYFARELIMKKTGLTIVTNSLSLANELVEHSNFSIIIIGGNVRKNERSLYGPVANQTIANLYVDTGFFGIGALHPEVGYTNIHMGEAEVSRLMVQHSKRRVMMADYSKFGSIHMNKVAPIEEVDTLITDSKADAEMLKAIQAKARNVIVVEAEGGEGDE
>NC_006582.1|WP_011248410.1|3718245_3718725_-|PTS-sugar-transporter-subunit-IIA
MSNALLDRDLILLNQTCQTVEEVLETIAAPMQAKQFAKETYADGLKEREQSFATGIPTEPFGVAIPHTDASYVLESKIGLLTLKEPVSFGVMGSENDQIDVKVVLLLGLADGSAHLKALQTIVERIQDAHFVKKLASVQEKDEALALLDASITKQLEGE
>NC_006582.1|WP_011248409.1|3717967_3718243_-|PTS-galactitol-transporter-subunit-IIB
MKKVLVACGGAVATSTVAANKVKAILKENNIQADVSQCRVSELGSKAQGADLIISTAKVDRDYGVPVIHGLPFISGVGLDKTKQEILDILK
>NC_006582.1|WP_011248408.1|3716595_3717942_-|PTS-galactitol-transporter-subunit-IIC
MNVLQYILDLGPAVMLPAVIFVLGLLLRQGIGKSLRSGITIGVGFVGITLVISLLTDNLGPAAQEMAERFNLGLSIVDVGWPGASPMAWASNIGTVAIPVAILVNVVMLLLKWTRVVNVDIWNIWHMAFAGAIVSTASGSFWLGVLGVVIYAAFAYKLGDWFAPIIHKYNGLEGISIPHGTGAIMAPIAVVTDAIIEKIPGLKNVNINSDKIENRLGPIGEPAIIGAILGTVIGALAGYEVSAILQLGIQMAAVMLLMPTVVKFIMEGLMPIAEAAREMLDKRFSGQDYYIGLDPALLLGNSQVVAASLIFVPLTLVIAILIPGNEVLPFGDLATIGFFISIAVGIHGGNLFRTLISGTLIMTMTIWIANMMVGVHTQLALNTGTISGGQVASLDQGGSPLQFIMTELTTWQNLLPLIVVTAIYGFCVVFTIVQHKRGKLLPAETDKN
>NC_006582.1|WP_011248407.1|3715516_3716575_-|galactitol-1-phosphate-5-dehydrogenase
MKALVLEANQSFTIKDIETPVPKEDEALIKVAYCGICGSDLARYFDGKVHNYPIVLGHEFSGTVEAVGASVDSVAVGDRVVVAPLLPNKDDPFMQKGSPALSSSYSFLGSRENGAMAEYVVVKAENLLVLPETVTLAEAALIEPLTVAIHGIERIVLPAGEHVCVLGAGTIGIMTILALKARGAGKVTAIDINDEKLAFAKKIGADDTINSLKEDPVSYASKHGKPGAVIETAGVPSSQEQAVALVEKKGKIVFVGTASGDVTFPAATFEKILREELEITGSWMSYSGPFPGYEWQAAIDYIASGKIDVKPLIHDVFKLEDGDKPFQAMKDPDNHSIKLLYQIAENEGQVGK
>NC_006582.1|WP_011248406.1|3714646_3715516_-|class-II-fructose-bisphosphate-aldolase
MGLQSTTPMLKKAKANKHGIVAFNVHSFDSIFWVLEAAAELKSPVILQTTVGTVKSLGAKNIAEVAKAAAEHYQVPTGLHLDHCTDFEVIKDAIRAGYTSVMMDASMHPFAENVARTKEVVALASSLGVNVEAELGKVGGVEDDIVVDEADAQKAIPEECRQFVEETDVPTLAPAIGTAHGIYKGKPEIDFERIAKIAEMVDVPLVLHGGSAVPEEDVRRCVALGMAKVNVSTELKNAYSEAIRDHFANEPDSLDPRAYLQKAKEAAKEMAKSKIRMVGSENTVVPAFV
>NC_006582.1|WP_011248404.1|3712378_3713806_-|collagen-binding-domain-containing-protein
MEKVDAADQQLLLAGAVFSLLDEAGNVLEENLMTDQHGRLEINNLPPGDYQLVETKAPEHYQLDATPIVFTIEKGQTVTPVITVENTLIPGAAALIKVDQDNGDIRLAGAEFMLTDADGNVVAEQLVTDENGLVAVSDLVPGTYYFVETKAPLHYERDAEPVAVTVEKGQTEAAVVKKSNTLIPGAVVLEKVDSSDHSTLLAGAEFRLEDEQGTVIQEKLVTDETGRIIVTDLKPGNYQFVETKAPNGYDLNEEGLAFTIERSQEAAVVVKAENTLTPGSVEIVKVDSSDGARLEGAVFTVLTEDGDMVAEGLTTDESGSVQLDGLAPGTYQLVETKAPAHYQLNETPIAFEISKGQTERLVLTVENTLIPPGEEPKEPQPPSEPKQPPTEPGDGQTPTGPQNNNGGTGTGKTGTPKAGGGDPSPLLSKGAQPASGGQLPQTGETEMFMFMVAGLLLMAIGALTLVNGRLARKRG
>NC_006582.1|WP_011248403.1|3711771_3712362_-|class-D-sortase
MRKRTLFIGMLLIIAGLALVAVPLTKEWQQANGVAQLEKALAAVQTGETIEKTDDSPSSWTKEQLEAVMELEIPAIDLKQYILDETTDENLALTLTQIKQEQVPGEGNFAVAGHRGYRGDRHFRQLPNVQKGDEIRLHADDGKTYIYVVKSTEIIEPTDVDVLNDGEQPEITLITCTLSGQQRVAVKGDLIDVIEA
>NC_006582.1|WP_011248401.1|3711125_3711464_+|helix-turn-helix-domain-containing-protein
MAELNDRLRELRKAHQLTQQEVASFLGITESAYGFYEQGRNEPSIAKLKQLAEKYNVSIAYIAGETDIKTAPSDKVKENGSAYTFTNLDEEEKEFLGEQLELFRRLKKKKGH
>NC_006582.1|WP_050749064.1|3722154_3722622_-|HXXEE-domain-containing-protein
MIHDFEEIIFVEGWVKKRYESVYQRIPSFYRPIFRIFNGMTGSQFAFAVFIEFIVFIPVTYLAAEQQMFTWFIGFNVIAFLHVFTHAGQALLLRMYTPGVITAIIVTLPYSLYLFYRLEAEYNIQVNDLIASIPYGLTIIPIVAFGHLLAKKVIR
>NC_006582.1|WP_011248414.1|3722718_3723453_-|SMI1/KNR4-family-protein
MKASIENLLRLLGDQHEAHHGIPESEIEAKERELGFSLPLVLRNYYKALGRSPHITQGCNNQYEPLPLEKLFIPDSTFFTTDKAFLVFYQVEESVIYCGIRLDELEKEDPPVYLCAWSFADWQLENQSLSRFLAGKALVQLGVEDRLPYWAIFDESTWNLSDYHDWMRLDDHEDEIEEGSELNTWKIFVKDDVLIVFELSGSEEEEAPLAAYLASFKRTSMVNLLNELEKAANLPAYRTNLFEQ
>NC_006582.1|WP_041824836.1|3723521_3723995_-|DUF5381-family-protein
MNAISYRKSVAWGKALGSLVFVLVCLFLLYVAFFTDATLIHTFFCITSAIIGIPFFGGYLVVCLPRALKSNTQLLTYDQQAISDGKQTVAWVDIANISYSGPSIQKWLLPQFPQLIFHLKNRETWTVNTYYLLTDTEIQSVMKLLRGLISRNSKEIK
>NC_006582.1|WP_011248416.1|3724190_3724676_-|DUF1648-domain-containing-protein
MEKPKNGHSKIENLLVFLSAVFFIYHLTFLINAWPDIPNQIAFHYSNGIPDNFRPKYLLIVIPLIGVLMWCLLGFLVRKPEKLNYINLTEANKDLQYMKARKIMSVVQNASFIMLLFANEAFIRGAMGLEFSFQLSISLLLLVICNLTPLYFLIWAFRLKY
>NC_006582.1|WP_011248417.1|3724804_3725563_-|MurR/RpiR-family-transcriptional-regulator
MILDKLVNKHFESLSENDLHIIKTIYDHIDEMKTMKIQDLAAYAHTSISSIHRLTKKIGLDGYSDLKSYIKLNNFTEGTSQDLMELLDQDIHQTRKYMEQLDFCQLNRLIDRAPYIYIYGTGAAQLDLANDVQRQLWTLHKKSQVIRSERDFTNGLGEMGENDLLFIISLSGESENLDEIIHAIKTRRIKCVSLTTLRNNLLAQNAMFNIYVNSTPFWLYNKVENSSFLPFYIVVDIIVRKFSEWKMEQLKK
>NC_006582.1|WP_011248418.1|3725707_3727291_+|PTS-transporter-subunit-EIIC
MNAIKRFGSAMIVPVLLFAFFGIVVGLATLFKNPAIMGDIAAEGTMWYKVWSLIESGGWTIFNHMELAFVIGLPISLAKKAQARATLAALMVYLVFNNFINAILTLWPSTFGVDLSQGVENITGVKEIAGIPTLDTNIIGAIVISAVVIWIHNRFYDQKLPEMLGIFQGLVFVVIIGFFVMIPFAFLVAFVWPYVQQGIGSLQGFISQAGYVGVWLFHFLERVLIPTGLHHFIYTPFEFGPAAVNEGLKPYWIANLNDFATSTSALKDLYPYGFLLHGNIKMFGCLGIALAMYYSTPKENRKKVLALVLPATLTAIFAGITEPLEFTFLFIAPYLFVIHALLGATMVTLMNMFGVVGMMGGGLIEIAALNWIPLASNHGSIYIVQAMIGLIFAALYFVLFRWMIVKFDIPLPGRKKEEKARLYTKQDYQKVKKGSNSEKQAAATYESEYEEKAVYYLEGLGGKENIKDVTNCATRLRVTVIDPSLVKDSDYFTNNKMAHGLAKSGQSIQIIVGLSVPQVRDSFEAKL
>NC_006582.1|WP_011248419.1|3727317_3728643_+|6-phospho-alpha-glucosidase
MKTFNITIAGGGSTFTPGIILMLLDYLDEFPIDTIKLYDNDGDRQKTIADACAILLKERAPEVRLLASTNPEEAFTNIDFVMAHIRVGKYAMRELDEKIPLKHGVVGQETCGPGGIAYGMRSIPGVLELIDYMEKYSPEAWMLNYSNPAAIVAEATRKLRPHSKVLNICDMPIGIEELIAKNLGFASRKEMEVDYYGLNHFGWWTDIRDKNGLSLMPDVIKHVSQHGYATDGTSELEQQESWNSTLKKARDVQALDPETVPNTYLKYYLYPDYEVAHSNKEYTRANEVMEGREKFVFGECQAIIDKGTAKETKLVIDEHASYIVDLAKAIAFNTKERMLMIVENNGAIPNFDPTAMVEIPCLVGSNGPEKLVVGEIPRFQKSLMEQQVGVEKLVVEAFEEGSYQKLWQAITLSKTVPSAKVAKDILDDLIEANKAFWPALK
>NC_006582.1|WP_011248420.1|3729930_3731295_-|FAD-dependent-oxidoreductase
MRQVTEIEKQVRVRAEADVVVCGGGPAGIGAALSAARNGAKTILLESHGFLGGMGTAGMVTSFAYGYHDKERFITGGIFQEIRQKLHDRGGLIMTDRKGWEPFNAEQYKILAFELLAEAGVELLCHTTVVDTITKAGTIEAIIIESKAGREALLATHVIDATGDGDVAERAGAICKIGRDKDGGTQPSSLMYVLGNVDTAALGEKLDQEGRRGYWKTEDGYRYVNATGFADEIEQAKRDGFLTKVNRDHIAAIFTVPWVDNVVGINFGRIQGKNALDPQDLTDAEVIGREQVLDGIAFLKEYVPGFKRAELLQTAPQVGIRETRRIIGDYVITQEDIVELKQFDDCIAQSCYMIDIHSPDSSTTEIYKLPKGTHYDIPYRALLPQGLNNLLVAGRCISATHEALGSFRVQAICLAIGEAAGAAAAIATKEKCLPREIDVKHLQDTLVNQGAILS
>NC_006582.1|WP_011248421.1|3731321_3732155_-|carbohydrate-ABC-transporter-permease
MKINSVSTVVRYGLLTIISAIMLLPFIWMVTTSLKDPNQIFALPPTFIPNPIQWDSYLNVLSSTHFLRQMFNSIYIGATVTIGTVLLASLAGYAFARIPFKGRNVVFLAFLSVMMIPGEVTIIPLFLFMRELGWIDTHLPLMIIPIFGAGGAFGIFVMRQFFKQVPAELEDAARIDGCSRFRIFVQIMLPLSKPALATVTIFTFLTNWNEFLEPLIFINSRELMTLPLALSLFTDEAGTDWSSLMSASVLATLPVLTVFFFAQKQFIESLAMSGSKE
>NC_006582.1|WP_142301323.1|3732144_3733017_-|ABC-transporter-permease-subunit
MFKRDELAGWLFISPMLLGFTIFMFIPIGFAFYMSFTDWPLLGQSEFIGTANYQAIVQDPEFQQVMKNTVLFTAGLVPFNIILALGLALLLRHPLPGMGLFRTIVFVPVVTTLVVWAIVWRYMFATDFGFINSILAWFGIESQAWLYNKNLAMPVVILTSVLKNVGLNMVLFLAALQMVPKNLYEAARIDGAGSWRQFKNITLPIISPTVFLATIITIIGAMKIFAQIFVMTKGGPESSTKVIVYYIWEKAFRLFDMGYASAAAFILFFVIFAFTLIQWWLRKRWVYNED

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Crispr_ID: NC_006582_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006582_4

3728825-3729521

TypeI

NA:I-C

Consensus_repeat	Method
ATTTCAATCCACGCACTCAC	PILER-CR
ATTTCAATCCACGCACTCACATAGAGTGCGAC	CRISPRCasFinder
ATTTCAATCCACGCACTCAC	CRT

10 spacers

cas2

The CRISPR arrays of NC_006582_4

>merge|NC_006582|4|3728825-3729521|PILER-CR,CRISPRCasFinder,CRT
ATTTCAATCCACGCACTCACTAAGAGTGCGACGTTGCTGTTTGGAACACATGAAGTTATCGTTCTTTCATTTCAATCCACGCACTCACTAAGAGTGCGGCGAGGGGCAAAGCTGTGGGTAGCCCAAATTCCTGAATTTCAATCCACGCACTCACTAAGAGTGCGACTGGGTCTTTTGTCAAACGTCCAACTAAATTTACTATTTCAATCCACGCACTCACTAAGAGTGCGACGATTTAGAACGCGAAAAGGTGCCGGGGCGGGTAAGATTTCAATCCACGCACTCACATAGAGTGCGACGGAGGGGCGTCATAATACTGCCACCAACTACGATATTTCAATCCACGCACTCACATAGAGTGCGACAGCAAACGCAAGTCTAGACCCTATTCGTCGTTTAATTTCAATCCACGCACTCACATAGAGTGCGACAATATCCTTGATGGACTACAGGCACAGATTGACGAGTATTTCAATCCACGCACTCACATAGAGTGCGACCACTCCCCTGTGGTTTTATCTTTGTAACGTAAGCGATTTCAATCCACGCACTCACATAGAGTGCGACATTAACAGCGTGAGAACTGTTGGTAAGCCAACAATTTCAATCCACGCACTCACATAGAGTGCGACGCGAGGATTTCAAGCGGGAATTAAATCCACTGTATTTCAATCCACGCACTCACATAGAGTGCGAC

>NC_006582|4|3|3728825-3729509|PILER-CR
ATTTCAATCCACGCACTCAC	TAAGAGTGCGACGTTGCTGTTTGGAACACATGAAGTTATCGTTCTTTC
ATTTCAATCCACGCACTCAC	TAAGAGTGCGGCGAGGGGCAAAGCTGTGGGTAGCCCAAATTCCTGA
ATTTCAATCCACGCACTCAC	TAAGAGTGCGACTGGGTCTTTTGTCAAACGTCCAACTAAATTTACT
ATTTCAATCCACGCACTCAC	TAAGAGTGCGACGATTTAGAACGCGAAAAGGTGCCGGGGCGGGTAAG
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACGGAGGGGCGTCATAATACTGCCACCAACTACGAT
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACAGCAAACGCAAGTCTAGACCCTATTCGTCGTTTA
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACAATATCCTTGATGGACTACAGGCACAGATTGACGAGT
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACCACTCCCCTGTGGTTTTATCTTTGTAACGTAAGCG
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACATTAACAGCGTGAGAACTGTTGGTAAGCCAACA
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACGCGAGGATTTCAAGCGGGAATTAAATCCACTGT
ATTTCAATCCACGCACTCAC

>NC_006582|4|4|3728825-3729521|CRISPRCasFinder
ATTTCAATCCACGCACTCACTAAGAGTGCGAC	GTTGCTGTTTGGAACACATGAAGTTATCGTTCTTTC
ATTTCAATCCACGCACTCACTAAGAGTGCGGC	GAGGGGCAAAGCTGTGGGTAGCCCAAATTCCTGA
ATTTCAATCCACGCACTCACTAAGAGTGCGAC	TGGGTCTTTTGTCAAACGTCCAACTAAATTTACT
ATTTCAATCCACGCACTCACTAAGAGTGCGAC	GATTTAGAACGCGAAAAGGTGCCGGGGCGGGTAAG
ATTTCAATCCACGCACTCACATAGAGTGCGAC	GGAGGGGCGTCATAATACTGCCACCAACTACGAT
ATTTCAATCCACGCACTCACATAGAGTGCGAC	AGCAAACGCAAGTCTAGACCCTATTCGTCGTTTA
ATTTCAATCCACGCACTCACATAGAGTGCGAC	AATATCCTTGATGGACTACAGGCACAGATTGACGAGT
ATTTCAATCCACGCACTCACATAGAGTGCGAC	CACTCCCCTGTGGTTTTATCTTTGTAACGTAAGCG
ATTTCAATCCACGCACTCACATAGAGTGCGAC	ATTAACAGCGTGAGAACTGTTGGTAAGCCAACA
ATTTCAATCCACGCACTCACATAGAGTGCGAC	GCGAGGATTTCAAGCGGGAATTAAATCCACTGT
ATTTCAATCCACGCACTCACATAGAGTGCGAC

>NC_006582|4|3|3728825-3729509|CRT
ATTTCAATCCACGCACTCAC	TAAGAGTGCGACGTTGCTGTTTGGAACACATGAAGTTATCGTTCTTTC
ATTTCAATCCACGCACTCAC	TAAGAGTGCGGCGAGGGGCAAAGCTGTGGGTAGCCCAAATTCCTGA
ATTTCAATCCACGCACTCAC	TAAGAGTGCGACTGGGTCTTTTGTCAAACGTCCAACTAAATTTACT
ATTTCAATCCACGCACTCAC	TAAGAGTGCGACGATTTAGAACGCGAAAAGGTGCCGGGGCGGGTAAG
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACGGAGGGGCGTCATAATACTGCCACCAACTACGAT
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACAGCAAACGCAAGTCTAGACCCTATTCGTCGTTTA
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACAATATCCTTGATGGACTACAGGCACAGATTGACGAGT
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACCACTCCCCTGTGGTTTTATCTTTGTAACGTAAGCG
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACATTAACAGCGTGAGAACTGTTGGTAAGCCAACA
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACGCGAGGATTTCAAGCGGGAATTAAATCCACTGT
ATTTCAATCCACGCACTCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_006582.1\|WP_011248416.1\|3724190_3724676_-\|DUF1648-domain-containing-protein	unknown	unknown	gnl\|CDD\|377929
NC_006582.1\|WP_011248412.1\|3719688_3720633_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238570
NC_006582.1\|WP_011248417.1\|3724804_3725563_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NC_006582.1\|WP_011248418.1\|3725707_3727291_+\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273925
NC_006582.1\|WP_050749064.1\|3722154_3722622_-\|HXXEE-domain-containing-protein	unknown	unknown	gnl\|CDD\|379370
NC_006582.1\|WP_041824839.1\|3741785_3742076_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_006582.1\|WP_011248410.1\|3718245_3718725_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
NC_006582.1\|WP_011248421.1\|3731321_3732155_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_006582.1\|WP_011248428.1\|3740577_3740991_-\|hypothetical-protein	unknown	unknown	unknown
NC_006582.1\|WP_011248411.1\|3718717_3719506_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_006582.1\|WP_011248423.1\|3733093_3734359_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NC_006582.1\|WP_011248414.1\|3722718_3723453_-\|SMI1/KNR4-family-protein	unknown	unknown	gnl\|CDD\|378155
NC_006582.1\|WP_011248420.1\|3729930_3731295_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NC_006582.1\|WP_011248426.1\|3736976_3738275_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350107
NC_006582.1\|WP_035203525.1\|3736203_3736920_-\|response-regulator	unknown	unknown	gnl\|CDD\|381091
NC_006582.1\|WP_142301323.1\|3732144_3733017_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NC_006582.1\|WP_041824836.1\|3723521_3723995_-\|DUF5381-family-protein	unknown	unknown	gnl\|CDD\|375146
NC_006582.1\|WP_011248427.1\|3738258_3738762_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350105
NC_006582.1\|WP_011248419.1\|3727317_3728643_+\|6-phospho-alpha-glucosidase	unknown	unknown	gnl\|CDD\|133434
NC_006582.1\|WP_011248424.1\|3734449_3736183_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519

Protein	Function_ID	Function_description	E-value
NC_006582.1\|WP_011248416.1\|3724190_3724676_-\|DUF1648-domain-containing-protein	gnl\|CDD\|377929	pfam07853, DUF1648, Protein of unknown function (DUF1648). Members of this family are hypothetical proteins expressed by either bacterial or archaeal species. Some of these are annotated as being transmembrane proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues.	0.00239141
NC_006582.1\|WP_011248412.1\|3719688_3720633_+\|hypothetical-protein	gnl\|CDD\|238570	cd01164, FruK_PfkB_like, 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.	9.9041e-65
NC_006582.1\|WP_011248417.1\|3724804_3725563_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	8.9767e-36
NC_006582.1\|WP_011248418.1\|3725707_3727291_+\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273925	TIGR02005, PTS-IIBC-alpha, PTS system, alpha-glucoside-specific IIBC component. This model represents a family of fused PTS enzyme II B and C domains. A gene from Clostridium has been partially characterized as a maltose transporter, while genes from Fusobacterium and Klebsiella have been proposed to transport the five non-standard isomers of sucrose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NC_006582.1\|WP_050749064.1\|3722154_3722622_-\|HXXEE-domain-containing-protein	gnl\|CDD\|379370	pfam13787, HXXEE, Protein of unknown function with HXXEE motif. This domain contains an HXXEE motif, another conserved histidine and a YXPG motif. Its function is unknown.	8.61486e-15
NC_006582.1\|WP_041824839.1\|3741785_3742076_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	6.6055e-35
NC_006582.1\|WP_011248410.1\|3718245_3718725_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	2.57201e-35
NC_006582.1\|WP_011248421.1\|3731321_3732155_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.45871e-90
NC_006582.1\|WP_011248411.1\|3718717_3719506_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	4.3258e-90
NC_006582.1\|WP_011248423.1\|3733093_3734359_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.40995e-65
NC_006582.1\|WP_011248414.1\|3722718_3723453_-\|SMI1/KNR4-family-protein	gnl\|CDD\|378155	pfam09346, SMI1_KNR4, SMI1 / KNR4 family (SUKH-1). Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.	5.58852e-06
NC_006582.1\|WP_011248420.1\|3729930_3731295_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	2.05904e-149
NC_006582.1\|WP_011248426.1\|3736976_3738275_-\|hypothetical-protein	gnl\|CDD\|350107	cd08993, GH130, Glycosyl hydrolase family 130. This subfamily contains glycosyl hydrolase family 130 (GH130) proteins, as classified by the carbohydrate-active enzymes database (CAZY), are phosphorylases and hydrolases for beta-mannosides, and include beta-1,4-mannosylglucose phosphorylase (EC 2.4.1.281), beta-1,4-mannooligosaccharide phosphorylase (EC 2.4.1.319), among others that have yet to be characterized. They possess 5-bladed beta-propeller domains similar to families 32, 43, 62, 68, 117 (GH32, GH43, GH62, GH68, GH117). GH130 enzymes are involved in the bacterial utilization of mannans or N-linked glycans. Beta-1,4-mannosylglucose phosphorylase is involved in degradation of beta-1,4-D-mannosyl-N-acetyl-D-glucosamine linkages in the core of N-glycans; it produces alpha-mannose 1-phosphate and glucose from 4-O-beta-D-mannosyl-D-glucose and inorganic phosphate, using a critical catalytic Asp as a proton donor. This family includes Ruminococcus albus 4-O-beta-D-mannosyl-D-glucose phosphorylase (RaMP1) and beta-(1,4)-mannooligosaccharide phosphorylase (RaMP2), enzymes that phosphorolyze beta-mannosidic linkages at the non-reducing ends of their substrates, and have substantially diverse substrate specificity that are determined by three loop regions.	2.50971e-05
NC_006582.1\|WP_035203525.1\|3736203_3736920_-\|response-regulator	gnl\|CDD\|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.02798e-53
NC_006582.1\|WP_142301323.1\|3732144_3733017_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.06172e-89
NC_006582.1\|WP_041824836.1\|3723521_3723995_-\|DUF5381-family-protein	gnl\|CDD\|375146	pfam17353, DUF5381, Family of unknown function (DUF5381). This is a family of unknown function found in Bacillales.	0.00404155
NC_006582.1\|WP_011248427.1\|3738258_3738762_-\|hypothetical-protein	gnl\|CDD\|350105	cd08991, GH43_HoAraf43-like, Glycosyl hydrolase family 43 protein such as Halothermothrix orenii H 168 alpha-L-arabinofuranosidase (HoAraf43;Hore_20580). This glycosyl hydrolase family 43 (GH43) subgroup includes Halothermothrix orenii H 168 alpha-L-arabinofuranosidase (EC 3.2.1.55) (HoAraf43;Hore_20580). It belongs to the glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) which includes family 43 (GH43) and 62 (GH62) families. This GH43_ HoAraf43-like subgroup includes enzymes that have been annotated as having xylan-digesting beta-xylosidase (EC 3.2.1.37) and xylanase (endo-alpha-L-arabinanase, EC 3.2.1.8) activities. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	3.46484e-06
NC_006582.1\|WP_011248419.1\|3727317_3728643_+\|6-phospho-alpha-glucosidase	gnl\|CDD\|133434	cd05298, GH4_GlvA_pagL_like, Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases. Bacillus subtilis GlvA and Clostridium acetobutylicum pagL are 6-phospho-alpha-glucosidase, catalyzing the hydrolysis of alpha-glucopyranoside bonds to release glucose from oligosaccharides. The substrate specificities of other members of this subgroup are unknown. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP_PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases, which include 6-phospho-beta-glucosidases, 6-phospho-alpha-glucosidases, alpha-glucosidases/alpha-glucuronidases (only from Thermotoga), and alpha-galactosidases. Members of this subfamily are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NC_006582.1\|WP_011248424.1\|3734449_3736183_-\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	3.40827e-55

>NC_006582.1|WP_011248419.1|3727317_3728643_+|6-phospho-alpha-glucosidase
MKTFNITIAGGGSTFTPGIILMLLDYLDEFPIDTIKLYDNDGDRQKTIADACAILLKERAPEVRLLASTNPEEAFTNIDFVMAHIRVGKYAMRELDEKIPLKHGVVGQETCGPGGIAYGMRSIPGVLELIDYMEKYSPEAWMLNYSNPAAIVAEATRKLRPHSKVLNICDMPIGIEELIAKNLGFASRKEMEVDYYGLNHFGWWTDIRDKNGLSLMPDVIKHVSQHGYATDGTSELEQQESWNSTLKKARDVQALDPETVPNTYLKYYLYPDYEVAHSNKEYTRANEVMEGREKFVFGECQAIIDKGTAKETKLVIDEHASYIVDLAKAIAFNTKERMLMIVENNGAIPNFDPTAMVEIPCLVGSNGPEKLVVGEIPRFQKSLMEQQVGVEKLVVEAFEEGSYQKLWQAITLSKTVPSAKVAKDILDDLIEANKAFWPALK
>NC_006582.1|WP_011248418.1|3725707_3727291_+|PTS-transporter-subunit-EIIC
MNAIKRFGSAMIVPVLLFAFFGIVVGLATLFKNPAIMGDIAAEGTMWYKVWSLIESGGWTIFNHMELAFVIGLPISLAKKAQARATLAALMVYLVFNNFINAILTLWPSTFGVDLSQGVENITGVKEIAGIPTLDTNIIGAIVISAVVIWIHNRFYDQKLPEMLGIFQGLVFVVIIGFFVMIPFAFLVAFVWPYVQQGIGSLQGFISQAGYVGVWLFHFLERVLIPTGLHHFIYTPFEFGPAAVNEGLKPYWIANLNDFATSTSALKDLYPYGFLLHGNIKMFGCLGIALAMYYSTPKENRKKVLALVLPATLTAIFAGITEPLEFTFLFIAPYLFVIHALLGATMVTLMNMFGVVGMMGGGLIEIAALNWIPLASNHGSIYIVQAMIGLIFAALYFVLFRWMIVKFDIPLPGRKKEEKARLYTKQDYQKVKKGSNSEKQAAATYESEYEEKAVYYLEGLGGKENIKDVTNCATRLRVTVIDPSLVKDSDYFTNNKMAHGLAKSGQSIQIIVGLSVPQVRDSFEAKL
>NC_006582.1|WP_011248417.1|3724804_3725563_-|MurR/RpiR-family-transcriptional-regulator
MILDKLVNKHFESLSENDLHIIKTIYDHIDEMKTMKIQDLAAYAHTSISSIHRLTKKIGLDGYSDLKSYIKLNNFTEGTSQDLMELLDQDIHQTRKYMEQLDFCQLNRLIDRAPYIYIYGTGAAQLDLANDVQRQLWTLHKKSQVIRSERDFTNGLGEMGENDLLFIISLSGESENLDEIIHAIKTRRIKCVSLTTLRNNLLAQNAMFNIYVNSTPFWLYNKVENSSFLPFYIVVDIIVRKFSEWKMEQLKK
>NC_006582.1|WP_011248416.1|3724190_3724676_-|DUF1648-domain-containing-protein
MEKPKNGHSKIENLLVFLSAVFFIYHLTFLINAWPDIPNQIAFHYSNGIPDNFRPKYLLIVIPLIGVLMWCLLGFLVRKPEKLNYINLTEANKDLQYMKARKIMSVVQNASFIMLLFANEAFIRGAMGLEFSFQLSISLLLLVICNLTPLYFLIWAFRLKY
>NC_006582.1|WP_041824836.1|3723521_3723995_-|DUF5381-family-protein
MNAISYRKSVAWGKALGSLVFVLVCLFLLYVAFFTDATLIHTFFCITSAIIGIPFFGGYLVVCLPRALKSNTQLLTYDQQAISDGKQTVAWVDIANISYSGPSIQKWLLPQFPQLIFHLKNRETWTVNTYYLLTDTEIQSVMKLLRGLISRNSKEIK
>NC_006582.1|WP_011248414.1|3722718_3723453_-|SMI1/KNR4-family-protein
MKASIENLLRLLGDQHEAHHGIPESEIEAKERELGFSLPLVLRNYYKALGRSPHITQGCNNQYEPLPLEKLFIPDSTFFTTDKAFLVFYQVEESVIYCGIRLDELEKEDPPVYLCAWSFADWQLENQSLSRFLAGKALVQLGVEDRLPYWAIFDESTWNLSDYHDWMRLDDHEDEIEEGSELNTWKIFVKDDVLIVFELSGSEEEEAPLAAYLASFKRTSMVNLLNELEKAANLPAYRTNLFEQ
>NC_006582.1|WP_050749064.1|3722154_3722622_-|HXXEE-domain-containing-protein
MIHDFEEIIFVEGWVKKRYESVYQRIPSFYRPIFRIFNGMTGSQFAFAVFIEFIVFIPVTYLAAEQQMFTWFIGFNVIAFLHVFTHAGQALLLRMYTPGVITAIIVTLPYSLYLFYRLEAEYNIQVNDLIASIPYGLTIIPIVAFGHLLAKKVIR
>NC_006582.1|WP_011248412.1|3719688_3720633_+|hypothetical-protein
MIHILCANPALDRTIYVQAFYPNGVTRSSASHEGLGGKGFNVALPFIVTNEQKTIHMHTFFGGPVGEQLAQMMKNAQLAGETTFIEGDNRYCTILVNESKQEAALINEQGPSITEKEQQQFLQSLFCSLKAGDHLVLSGSLPKGTPLTFYRDIIAQAESRGVQTILDSSGDALAYGAEAKPWLIKINGEEFLDLMGVKEEAANRQQQIEESLKNSPYPNCIVTLGGEGTVAKINGDIWRVTLPTINVTNATASGDIFLGTFIREWRKTNDVKAALLAGSALSLANCLHWLPTIDFSQAEQYQQKIHIERIGSAV
>NC_006582.1|WP_011248411.1|3718717_3719506_-|DeoR/GlpR-transcriptional-regulator
MLPQERQDLIMKELYEYHSVKISELSSKLDVTRETIRKDLYELEEKGLIRKVHGGAVLNKANLETNYSSRKIVNEWEKRAIAKKAVEFVFDNDTIYIDYGTTALYFARELIMKKTGLTIVTNSLSLANELVEHSNFSIIIIGGNVRKNERSLYGPVANQTIANLYVDTGFFGIGALHPEVGYTNIHMGEAEVSRLMVQHSKRRVMMADYSKFGSIHMNKVAPIEEVDTLITDSKADAEMLKAIQAKARNVIVVEAEGGEGDE
>NC_006582.1|WP_011248410.1|3718245_3718725_-|PTS-sugar-transporter-subunit-IIA
MSNALLDRDLILLNQTCQTVEEVLETIAAPMQAKQFAKETYADGLKEREQSFATGIPTEPFGVAIPHTDASYVLESKIGLLTLKEPVSFGVMGSENDQIDVKVVLLLGLADGSAHLKALQTIVERIQDAHFVKKLASVQEKDEALALLDASITKQLEGE
>NC_006582.1|WP_011248420.1|3729930_3731295_-|FAD-dependent-oxidoreductase
MRQVTEIEKQVRVRAEADVVVCGGGPAGIGAALSAARNGAKTILLESHGFLGGMGTAGMVTSFAYGYHDKERFITGGIFQEIRQKLHDRGGLIMTDRKGWEPFNAEQYKILAFELLAEAGVELLCHTTVVDTITKAGTIEAIIIESKAGREALLATHVIDATGDGDVAERAGAICKIGRDKDGGTQPSSLMYVLGNVDTAALGEKLDQEGRRGYWKTEDGYRYVNATGFADEIEQAKRDGFLTKVNRDHIAAIFTVPWVDNVVGINFGRIQGKNALDPQDLTDAEVIGREQVLDGIAFLKEYVPGFKRAELLQTAPQVGIRETRRIIGDYVITQEDIVELKQFDDCIAQSCYMIDIHSPDSSTTEIYKLPKGTHYDIPYRALLPQGLNNLLVAGRCISATHEALGSFRVQAICLAIGEAAGAAAAIATKEKCLPREIDVKHLQDTLVNQGAILS
>NC_006582.1|WP_011248421.1|3731321_3732155_-|carbohydrate-ABC-transporter-permease
MKINSVSTVVRYGLLTIISAIMLLPFIWMVTTSLKDPNQIFALPPTFIPNPIQWDSYLNVLSSTHFLRQMFNSIYIGATVTIGTVLLASLAGYAFARIPFKGRNVVFLAFLSVMMIPGEVTIIPLFLFMRELGWIDTHLPLMIIPIFGAGGAFGIFVMRQFFKQVPAELEDAARIDGCSRFRIFVQIMLPLSKPALATVTIFTFLTNWNEFLEPLIFINSRELMTLPLALSLFTDEAGTDWSSLMSASVLATLPVLTVFFFAQKQFIESLAMSGSKE
>NC_006582.1|WP_142301323.1|3732144_3733017_-|ABC-transporter-permease-subunit
MFKRDELAGWLFISPMLLGFTIFMFIPIGFAFYMSFTDWPLLGQSEFIGTANYQAIVQDPEFQQVMKNTVLFTAGLVPFNIILALGLALLLRHPLPGMGLFRTIVFVPVVTTLVVWAIVWRYMFATDFGFINSILAWFGIESQAWLYNKNLAMPVVILTSVLKNVGLNMVLFLAALQMVPKNLYEAARIDGAGSWRQFKNITLPIISPTVFLATIITIIGAMKIFAQIFVMTKGGPESSTKVIVYYIWEKAFRLFDMGYASAAAFILFFVIFAFTLIQWWLRKRWVYNED
>NC_006582.1|WP_011248423.1|3733093_3734359_-|sugar-ABC-transporter-substrate-binding-protein
MKRWSISAGLLLVVAGCSSSGGSTDANGDEQIELTFSTWGNENHIAVYEELLEAYYVDHPNVHVTIQTTPFPDYQQNMTVLAAGQELPDIGWAAERMVPQFIENNILADLSALREDESFHFEDILPGTITQYEVGDALYGVPFSSPPHIIFYNKTLFEKNGLETPQELESRGEWTWEAFEEAAAVIAEEEGVYGANFFRAWETWENLLAHTRAEGGDLFNEDTTEFTWNSDAGISTLEMLERMMFEDRSHPRAGDQVAFEAGNVGMFFDVYSYVSTAREIEDFEWDIAPVPLGSQGRSPILGQAGYVMFEGTEHPEEALDLIRYFASQTGMEATSTYFAPPRASVLESDAFIEQPGNPPRASMESTILNLSEESRVLPIHPEWQNIDNHILQGFDHLFGQTAEPADILEQMEASINPLVQE
>NC_006582.1|WP_011248424.1|3734449_3736183_-|sensor-histidine-kinase
MSLRPKIILLFLSIVLVPLNLLGMITYAYFSKTLEDQTYHYTVQVIGQVNQNVNAYIDEMHRLSLLPLYDRDILAILKNRSDVHHSYYPQTEEFERMSSFLSTLSYNRQELSGIHIITRDGSLFSDLGSPRTVHRLAEGTSDWQEAIEAGNGASLLLPTHSPSYVLGAEKSVFSVGRLLRDPDGFRPLGMIKVDIELSFIESLLEDVDLSEDASITMIDRNGEPIYETGKAIYPLLKGKGEDVWQLAERESIAVDGVDYLPVIRNDSSGDVQTIVFLPEHHIVGASQSLRLFTIGLMLAVSAVVIMLALVAERSLTKPIFELRQVMALAEKGEFHHRMNRSSKDELGQLAIGFNHMMKQINELIAKVYQTEIREKDAEIKALQTQMNPHFIYNTLEHINMMAITKQAYELSDMVASLGRLIRYSIDQKTRFVPLREELAFVESYITIQQKRLEGKVTFSIAVPEAMRSLSIPKLILQPLIENAIEHGHQHGEWPGEISIKGWQDDAYSYIEVRDSGQGMKQETIERMKEEPERGAGNQVALGNISERLLLLLGEQARLMIDSELGRGTKVTVRLPKT
>NC_006582.1|WP_035203525.1|3736203_3736920_-|response-regulator
MYKVVIAEDEKMIRKGLVTIVDQLVTDFTVIGEADNGERALELLAHDCPDVLLTDIRMPKCDGLSLIREARSYYPHVKIVIVSGHEEFAYAQQAIQHGVSRYLLKPIDRTEVVLAFDEIKRGLVEPEQEDHENHLIQQVDSYIKTHIDQDITLQAVAKLVHLHPTYFSQWFKNETGQNFSTYVTQKRLERAETLLHQTNLRVYEVARMSGYQNEKHFMKLFKKEKRCTPTQFRQRALL
>NC_006582.1|WP_011248426.1|3736976_3738275_-|hypothetical-protein
MTRLISEASYARVFEHELDGKDNRYVMLLMGNNNGTRRIYLAWSDDGREWEAQQEPLISPQPGQGGNLSGAYYFPYNGHHYVTVHGGSGNQYVVDVGENFDQEIHLGPYYQPSAVAPENGRAASRSYIYSEDELYMVYEAGQRGSTKIALARAILGDERVEMASASLRLPSRVVSTNSEIDFEVLARRYDGTTIAENELSFSLFSSDSSVVRVDGQRLYSGGEGIAEVRAEVSYQGKVITTEAISIEVRDGEVWNVIDERFDDYTRRWQIAKGSAAQGTIEQGAGFVDIIENRRSGGAYHYLTYEGFYLPNSFYTLEAELSVFAPSQGNEISIREGNRQKSLFITYDGKQGFIQDRLLQPTVAVEIDPTERARYKLVSTGQTTYDVYRNDEFLFRSTSVSQAGQNLVKVGADSQGSAALRVDALRIQTNTAP
>NC_006582.1|WP_011248427.1|3738258_3738762_-|hypothetical-protein
MKSPLKALTVSVILLLAGLVLGDDRMEAHELPLFHFEKTLIEPSEMRYNPTGEVDFPTVIRAADYFENPLGTYYMYYGPHDAPGGIALAYADSVTGPWTEYASNPVISRNWQPHYNVSHVASAHPIWNEEEGKLFLYFHGENSVTRLASSEDGIHFDYEQVVIDTSD
>NC_006582.1|WP_011248428.1|3740577_3740991_-|hypothetical-protein
MTWHNQDPLNLSKEEWINLLQDEKVFNKIGLEMVFFVYKQPNYQSNATEIGEALGGVSQQQVTAWNRSIAKKIYQKLQKEPPFNSRGGKRYWNVLFDGAVERELDDKGNFIWKLRPSLVSALKRLGTSCNKTAKIES
>NC_006582.1|WP_041824839.1|3741785_3742076_-|CRISPR-associated-endonuclease-Cas2
MLVLITYDVQTSSLGGSKRLRKVAKACQNYGQRVQNSVFECIVDSAQLTSLKLELSSLIDKEKDSLRIYRLGNNYKSKVEHIGAKPTVDIEDPLIF

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Crispr_ID: NC_006582_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006582_5

3739183-3740347

TypeI

I-C

Consensus_repeat	Method
ATTTCAATCCACGCACTCATATAGAGTGCGAC	CRISPRCasFinder
ATTTCAATCCACGCACTCATATAGAGTGCGAC	CRT
CCGGAATTTCAATCCACGCACTCATATAGAGTGCGACT	PILER-CR
ATTTCAATCCACGCACTCATATAGAGTGCGAC	PILER-CR

17 spacers

cas2,cas1,cas4,cas7,cas8c,cas5,cas3

The CRISPR arrays of NC_006582_5

>merge|NC_006582|5|3739183-3740347|CRISPRCasFinder,CRT,PILER-CR,PILER-CR
ATCGATTGGCACGCACTCATATAGAGTGCGACATCAAATTTCCGTCGAAACTCTGAACTCGTCCTGCATTTCAATCCACGCACTCATATAGAGTGCGACTGATTGGTAGTGGATTTTATCGAGCGTCTAGCGGAATTTCAATCCACGCACTCATATAGAGTGCGACTCTATGTTTCTTTCTCTCACTTCGTCATTCATAGATTTCAATCCACGCACTCATATAGAGTGCGACGTCATCTTGGATGAGGATGGACAAGTGGTTGTTCAATTTCAATCCACGCACTCATATAGAGTGCGACTCTGTTAATTCATGCTGAGAAGAAACAAGTAATGATTTCAATCCACGCACTCATATAGAGTGCGACAGGACTACACAAAGGCGATCTTAACGTTGATCGAATTTCAATCCACGCACTCATATAGAGTGCGACACCGTTGAAGCGCCTGAACCGCCTGAACCGCCTCCTATTTCAATCCACGCACTCATATAGAGTGCGACTAGAGGCATCGCGAACAGTGTCGCCTCTACAATATTTCAATCCACGCACTCATATAGAGTGCGACTTCTAGGCATCATCATAGTGGCCAACATTGTGGACAATTTCAATCCACGCACTCATATAGAGTGCGACAAAACGCATTGCGTGGTCATTTTGTGCAGGCATATATTTCAATCCACGCACTCATATAGAGTGCGACAAAGCCTAGTATCTCTTCCGCCTCAGAACGTAAGAATTTCAATCCACGCACTCATATAGAGTGCGACTCAAGCCTGTATTCCTGTGGGTACATCATTAGGTATTTCAATCCACGCACTCATATAGAGTGCGACTAATGATAGGCAATTGCTTCATTACGCAAAAGAATTTCAATCCACGCACTCATATAGAGTGCGACGATGACCGCTTTACCACACAAGAGGGTATCGATGCAATTTCAATCCACGCACTCATATAGAGTGCGACAAGGGGGCAAAAGACGCGATTGATGGATTAGGCGATTTCAATCCACGCACTCATATAGAGTGCGACTGCTGCAGTTGAGTAAATACACAATATTTGGGGCGATTTCAATCCACGCACTCATATAGAGTGCGACGGCCATTTCAAGAAATTGTACAAATACCATGAGGATTTCAATCCACGCACTCATATAGAGTGCGACA

>NC_006582|5|5|3739183-3740347|CRISPRCasFinder
ATCGATTGGCACGCACTCATATAGAGTGCGAC	ATCAAATTTCCGTCGAAACTCTGAACTCGTCCTGC
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TGATTGGTAGTGGATTTTATCGAGCGTCTAGCGGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TCTATGTTTCTTTCTCTCACTTCGTCATTCATAG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	GTCATCTTGGATGAGGATGGACAAGTGGTTGTTCA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TCTGTTAATTCATGCTGAGAAGAAACAAGTAATG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AGGACTACACAAAGGCGATCTTAACGTTGATCGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	ACCGTTGAAGCGCCTGAACCGCCTGAACCGCCTCCT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TAGAGGCATCGCGAACAGTGTCGCCTCTACAAT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TTCTAGGCATCATCATAGTGGCCAACATTGTGGACA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AAAACGCATTGCGTGGTCATTTTGTGCAGGCATAT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AAAGCCTAGTATCTCTTCCGCCTCAGAACGTAAGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TCAAGCCTGTATTCCTGTGGGTACATCATTAGGT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TAATGATAGGCAATTGCTTCATTACGCAAAAGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	GATGACCGCTTTACCACACAAGAGGGTATCGATGCA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AAGGGGGCAAAAGACGCGATTGATGGATTAGGCG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TGCTGCAGTTGAGTAAATACACAATATTTGGGGCG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	GGCCATTTCAAGAAATTGTACAAATACCATGAGG
ATTTCAATCCACGCACTCATATAGAGTGCGACA

>NC_006582|5|4|3739183-3740346|CRT
ATCGATTGGCACGCACTCATATAGAGTGCGAC	ATCAAATTTCCGTCGAAACTCTGAACTCGTCCTGC
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TGATTGGTAGTGGATTTTATCGAGCGTCTAGCGGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TCTATGTTTCTTTCTCTCACTTCGTCATTCATAG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	GTCATCTTGGATGAGGATGGACAAGTGGTTGTTCA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TCTGTTAATTCATGCTGAGAAGAAACAAGTAATG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AGGACTACACAAAGGCGATCTTAACGTTGATCGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	ACCGTTGAAGCGCCTGAACCGCCTGAACCGCCTCCT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TAGAGGCATCGCGAACAGTGTCGCCTCTACAAT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TTCTAGGCATCATCATAGTGGCCAACATTGTGGACA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AAAACGCATTGCGTGGTCATTTTGTGCAGGCATAT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AAAGCCTAGTATCTCTTCCGCCTCAGAACGTAAGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TCAAGCCTGTATTCCTGTGGGTACATCATTAGGT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TAATGATAGGCAATTGCTTCATTACGCAAAAGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	GATGACCGCTTTACCACACAAGAGGGTATCGATGCA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AAGGGGGCAAAAGACGCGATTGATGGATTAGGCG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TGCTGCAGTTGAGTAAATACACAATATTTGGGGCG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	GGCCATTTCAAGAAATTGTACAAATACCATGAGG
ATTTCAATCCACGCACTCATATAGAGTGCGAC

>NC_006582|5|4|3739192-3739349|PILER-CR
CACGCACTCATATAGAGTGCGACATCAAATTTCCGTCGAAACTC	TGAACTCGTCCTGCATTTCAATCC
ACGCACTCATATAGAGTGCGACTGATTGGTAGTGGATTTTATCG	AGCGTCTAGCGGAATTTCAATCCACGCAC
TCATATAGAGTGCGACTCTATGTTTCTTTCTCTCACTTCGTCATTCATAGATTTCAATCCACGCACTCATATAGAGTGCGACGTCATCTTGGATGAGGATGGACAAGTGGTTGTTCAATTTCAATCCACGCACTCATATAGAGTGCGAC	TCTGTTAATTCATGCTGAGAAGAAACAAGTAATG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AGGACTACACAAAGGCGATCTTAACGTTGATCGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	ACCGTTGAAGCGCCTGAACCGCCTGAACCGCCTCCT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TAGAGGCATCGCGAACAGTGTCGCCTCTACAAT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TTCTAGGCATCATCATAGTGGCCAACATTGTGGACA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AAAACGCATTGCGTGGTCATTTTGTGCAGGCATAT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AAAGCCTAGTATCTCTTCCGCCTCAGAACGTAAGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TCAAGCCTGTATTCCTGTGGGTACATCATTAGGT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TAATGATAGGCAATTGCTTCATTACGCAAAAGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	GATGACCGCTTTACCACACAAGAGGGTATCGATGCA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AAGGGGGCAAAAGACGCGATTGATGGATTAGGCG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TGCTGCAGTTGAGTAAATACACAATATTTGGGGCG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	GGCCATTTCAAGAAATTGTACAAATACCATGAGG


>NC_006582|5|5|3739450-3740346|PILER-CR
	TGAACTCGTCCTGCATTTCAATCC
ACGCACTCATATAGAGTGCGACTGATTGGTAGTGGATTTTATCG	AGCGTCTAGCGGAATTTCAATCCACGCAC
TCATATAGAGTGCGACTCTATGTTTCTTTCTCTCACTTCGTCATTCATAGATTTCAATCCACGCACTCATATAGAGTGCGACGTCATCTTGGATGAGGATGGACAAGTGGTTGTTCAATTTCAATCCACGCACTCATATAGAGTGCGAC	TCTGTTAATTCATGCTGAGAAGAAACAAGTAATG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AGGACTACACAAAGGCGATCTTAACGTTGATCGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	ACCGTTGAAGCGCCTGAACCGCCTGAACCGCCTCCT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TAGAGGCATCGCGAACAGTGTCGCCTCTACAAT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TTCTAGGCATCATCATAGTGGCCAACATTGTGGACA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AAAACGCATTGCGTGGTCATTTTGTGCAGGCATAT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AAAGCCTAGTATCTCTTCCGCCTCAGAACGTAAGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TCAAGCCTGTATTCCTGTGGGTACATCATTAGGT
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TAATGATAGGCAATTGCTTCATTACGCAAAAGA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	GATGACCGCTTTACCACACAAGAGGGTATCGATGCA
ATTTCAATCCACGCACTCATATAGAGTGCGAC	AAGGGGGCAAAAGACGCGATTGATGGATTAGGCG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	TGCTGCAGTTGAGTAAATACACAATATTTGGGGCG
ATTTCAATCCACGCACTCATATAGAGTGCGAC	GGCCATTTCAAGAAATTGTACAAATACCATGAGG
ATTTCAATCCACGCACTCATATAGAGTGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_006582.1\|WP_011248432.1\|3743761_3744619_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|226175
NC_006582.1\|WP_011248426.1\|3736976_3738275_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350107
NC_006582.1\|WP_041824839.1\|3741785_3742076_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_006582.1\|WP_011248437.1\|3752518_3754078_-\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NC_006582.1\|WP_011248421.1\|3731321_3732155_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_006582.1\|WP_011248428.1\|3740577_3740991_-\|hypothetical-protein	unknown	unknown	unknown
NC_006582.1\|WP_011248430.1\|3742084_3743116_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NC_006582.1\|WP_011248434.1\|3746500_3747211_-\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|273847
NC_006582.1\|WP_011248423.1\|3733093_3734359_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NC_006582.1\|WP_011248433.1\|3744615_3746499_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	gnl\|CDD\|187887
NC_006582.1\|WP_142301323.1\|3732144_3733017_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NC_006582.1\|WP_041824141.1\|3743112_3743772_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|224385
NC_006582.1\|WP_011248418.1\|3725707_3727291_+\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273925
NC_006582.1\|WP_011248436.1\|3750381_3751062_-\|amino-acid-racemase	unknown	unknown	gnl\|CDD\|224707
NC_006582.1\|WP_035203525.1\|3736203_3736920_-\|response-regulator	unknown	unknown	gnl\|CDD\|381091
NC_006582.1\|WP_011248420.1\|3729930_3731295_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NC_006582.1\|WP_011248427.1\|3738258_3738762_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350105
NC_006582.1\|WP_011248419.1\|3727317_3728643_+\|6-phospho-alpha-glucosidase	unknown	unknown	gnl\|CDD\|133434
NC_006582.1\|WP_011248435.1\|3747647_3750062_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_006582.1\|WP_011248424.1\|3734449_3736183_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519

Protein	Function_ID	Function_description	E-value
NC_006582.1\|WP_011248432.1\|3743761_3744619_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|226175	COG3649, COG3649, CRISPR system related protein [Defense mechanisms].	7.08843e-145
NC_006582.1\|WP_011248426.1\|3736976_3738275_-\|hypothetical-protein	gnl\|CDD\|350107	cd08993, GH130, Glycosyl hydrolase family 130. This subfamily contains glycosyl hydrolase family 130 (GH130) proteins, as classified by the carbohydrate-active enzymes database (CAZY), are phosphorylases and hydrolases for beta-mannosides, and include beta-1,4-mannosylglucose phosphorylase (EC 2.4.1.281), beta-1,4-mannooligosaccharide phosphorylase (EC 2.4.1.319), among others that have yet to be characterized. They possess 5-bladed beta-propeller domains similar to families 32, 43, 62, 68, 117 (GH32, GH43, GH62, GH68, GH117). GH130 enzymes are involved in the bacterial utilization of mannans or N-linked glycans. Beta-1,4-mannosylglucose phosphorylase is involved in degradation of beta-1,4-D-mannosyl-N-acetyl-D-glucosamine linkages in the core of N-glycans; it produces alpha-mannose 1-phosphate and glucose from 4-O-beta-D-mannosyl-D-glucose and inorganic phosphate, using a critical catalytic Asp as a proton donor. This family includes Ruminococcus albus 4-O-beta-D-mannosyl-D-glucose phosphorylase (RaMP1) and beta-(1,4)-mannooligosaccharide phosphorylase (RaMP2), enzymes that phosphorolyze beta-mannosidic linkages at the non-reducing ends of their substrates, and have substantially diverse substrate specificity that are determined by three loop regions.	2.50971e-05
NC_006582.1\|WP_041824839.1\|3741785_3742076_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	6.6055e-35
NC_006582.1\|WP_011248437.1\|3752518_3754078_-\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	3.30609e-146
NC_006582.1\|WP_011248421.1\|3731321_3732155_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.45871e-90
NC_006582.1\|WP_011248435.1\|3747647_3750062_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	2.77016e-125
NC_006582.1\|WP_011248430.1\|3742084_3743116_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NC_006582.1\|WP_011248434.1\|3746500_3747211_-\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|273847	TIGR01876, cas_Cas5d, CRISPR-associated protein Cas5, subtype I-C/DVULG. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum. This family belongs to a set of several Cas protein families, one each for a number of different CRISPR/Cas subtypes, that share a region of N-terminal sequence similarity modeled by TIGR02593. This family represents the Dvulg subtype of CRISPR/Cas locus.	3.75602e-116
NC_006582.1\|WP_011248423.1\|3733093_3734359_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.40995e-65
NC_006582.1\|WP_011248433.1\|3744615_3746499_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	0
NC_006582.1\|WP_142301323.1\|3732144_3733017_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.06172e-89
NC_006582.1\|WP_041824141.1\|3743112_3743772_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|224385	COG1468, COG1468, CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms].	2.73579e-37
NC_006582.1\|WP_011248418.1\|3725707_3727291_+\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273925	TIGR02005, PTS-IIBC-alpha, PTS system, alpha-glucoside-specific IIBC component. This model represents a family of fused PTS enzyme II B and C domains. A gene from Clostridium has been partially characterized as a maltose transporter, while genes from Fusobacterium and Klebsiella have been proposed to transport the five non-standard isomers of sucrose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NC_006582.1\|WP_035203525.1\|3736203_3736920_-\|response-regulator	gnl\|CDD\|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.02798e-53
NC_006582.1\|WP_011248420.1\|3729930_3731295_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	2.05904e-149
NC_006582.1\|WP_011248427.1\|3738258_3738762_-\|hypothetical-protein	gnl\|CDD\|350105	cd08991, GH43_HoAraf43-like, Glycosyl hydrolase family 43 protein such as Halothermothrix orenii H 168 alpha-L-arabinofuranosidase (HoAraf43;Hore_20580). This glycosyl hydrolase family 43 (GH43) subgroup includes Halothermothrix orenii H 168 alpha-L-arabinofuranosidase (EC 3.2.1.55) (HoAraf43;Hore_20580). It belongs to the glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) which includes family 43 (GH43) and 62 (GH62) families. This GH43_ HoAraf43-like subgroup includes enzymes that have been annotated as having xylan-digesting beta-xylosidase (EC 3.2.1.37) and xylanase (endo-alpha-L-arabinanase, EC 3.2.1.8) activities. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	3.46484e-06
NC_006582.1\|WP_011248419.1\|3727317_3728643_+\|6-phospho-alpha-glucosidase	gnl\|CDD\|133434	cd05298, GH4_GlvA_pagL_like, Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases. Bacillus subtilis GlvA and Clostridium acetobutylicum pagL are 6-phospho-alpha-glucosidase, catalyzing the hydrolysis of alpha-glucopyranoside bonds to release glucose from oligosaccharides. The substrate specificities of other members of this subgroup are unknown. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP_PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases, which include 6-phospho-beta-glucosidases, 6-phospho-alpha-glucosidases, alpha-glucosidases/alpha-glucuronidases (only from Thermotoga), and alpha-galactosidases. Members of this subfamily are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NC_006582.1\|WP_011248436.1\|3750381_3751062_-\|amino-acid-racemase	gnl\|CDD\|224707	COG1794, RacX, Aspartate racemase [Cell envelope biogenesis, outer membrane].	9.40651e-62
NC_006582.1\|WP_011248424.1\|3734449_3736183_-\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	3.40827e-55

>NC_006582.1|WP_011248427.1|3738258_3738762_-|hypothetical-protein
MKSPLKALTVSVILLLAGLVLGDDRMEAHELPLFHFEKTLIEPSEMRYNPTGEVDFPTVIRAADYFENPLGTYYMYYGPHDAPGGIALAYADSVTGPWTEYASNPVISRNWQPHYNVSHVASAHPIWNEEEGKLFLYFHGENSVTRLASSEDGIHFDYEQVVIDTSD
>NC_006582.1|WP_011248426.1|3736976_3738275_-|hypothetical-protein
MTRLISEASYARVFEHELDGKDNRYVMLLMGNNNGTRRIYLAWSDDGREWEAQQEPLISPQPGQGGNLSGAYYFPYNGHHYVTVHGGSGNQYVVDVGENFDQEIHLGPYYQPSAVAPENGRAASRSYIYSEDELYMVYEAGQRGSTKIALARAILGDERVEMASASLRLPSRVVSTNSEIDFEVLARRYDGTTIAENELSFSLFSSDSSVVRVDGQRLYSGGEGIAEVRAEVSYQGKVITTEAISIEVRDGEVWNVIDERFDDYTRRWQIAKGSAAQGTIEQGAGFVDIIENRRSGGAYHYLTYEGFYLPNSFYTLEAELSVFAPSQGNEISIREGNRQKSLFITYDGKQGFIQDRLLQPTVAVEIDPTERARYKLVSTGQTTYDVYRNDEFLFRSTSVSQAGQNLVKVGADSQGSAALRVDALRIQTNTAP
>NC_006582.1|WP_035203525.1|3736203_3736920_-|response-regulator
MYKVVIAEDEKMIRKGLVTIVDQLVTDFTVIGEADNGERALELLAHDCPDVLLTDIRMPKCDGLSLIREARSYYPHVKIVIVSGHEEFAYAQQAIQHGVSRYLLKPIDRTEVVLAFDEIKRGLVEPEQEDHENHLIQQVDSYIKTHIDQDITLQAVAKLVHLHPTYFSQWFKNETGQNFSTYVTQKRLERAETLLHQTNLRVYEVARMSGYQNEKHFMKLFKKEKRCTPTQFRQRALL
>NC_006582.1|WP_011248424.1|3734449_3736183_-|sensor-histidine-kinase
MSLRPKIILLFLSIVLVPLNLLGMITYAYFSKTLEDQTYHYTVQVIGQVNQNVNAYIDEMHRLSLLPLYDRDILAILKNRSDVHHSYYPQTEEFERMSSFLSTLSYNRQELSGIHIITRDGSLFSDLGSPRTVHRLAEGTSDWQEAIEAGNGASLLLPTHSPSYVLGAEKSVFSVGRLLRDPDGFRPLGMIKVDIELSFIESLLEDVDLSEDASITMIDRNGEPIYETGKAIYPLLKGKGEDVWQLAERESIAVDGVDYLPVIRNDSSGDVQTIVFLPEHHIVGASQSLRLFTIGLMLAVSAVVIMLALVAERSLTKPIFELRQVMALAEKGEFHHRMNRSSKDELGQLAIGFNHMMKQINELIAKVYQTEIREKDAEIKALQTQMNPHFIYNTLEHINMMAITKQAYELSDMVASLGRLIRYSIDQKTRFVPLREELAFVESYITIQQKRLEGKVTFSIAVPEAMRSLSIPKLILQPLIENAIEHGHQHGEWPGEISIKGWQDDAYSYIEVRDSGQGMKQETIERMKEEPERGAGNQVALGNISERLLLLLGEQARLMIDSELGRGTKVTVRLPKT
>NC_006582.1|WP_011248423.1|3733093_3734359_-|sugar-ABC-transporter-substrate-binding-protein
MKRWSISAGLLLVVAGCSSSGGSTDANGDEQIELTFSTWGNENHIAVYEELLEAYYVDHPNVHVTIQTTPFPDYQQNMTVLAAGQELPDIGWAAERMVPQFIENNILADLSALREDESFHFEDILPGTITQYEVGDALYGVPFSSPPHIIFYNKTLFEKNGLETPQELESRGEWTWEAFEEAAAVIAEEEGVYGANFFRAWETWENLLAHTRAEGGDLFNEDTTEFTWNSDAGISTLEMLERMMFEDRSHPRAGDQVAFEAGNVGMFFDVYSYVSTAREIEDFEWDIAPVPLGSQGRSPILGQAGYVMFEGTEHPEEALDLIRYFASQTGMEATSTYFAPPRASVLESDAFIEQPGNPPRASMESTILNLSEESRVLPIHPEWQNIDNHILQGFDHLFGQTAEPADILEQMEASINPLVQE
>NC_006582.1|WP_142301323.1|3732144_3733017_-|ABC-transporter-permease-subunit
MFKRDELAGWLFISPMLLGFTIFMFIPIGFAFYMSFTDWPLLGQSEFIGTANYQAIVQDPEFQQVMKNTVLFTAGLVPFNIILALGLALLLRHPLPGMGLFRTIVFVPVVTTLVVWAIVWRYMFATDFGFINSILAWFGIESQAWLYNKNLAMPVVILTSVLKNVGLNMVLFLAALQMVPKNLYEAARIDGAGSWRQFKNITLPIISPTVFLATIITIIGAMKIFAQIFVMTKGGPESSTKVIVYYIWEKAFRLFDMGYASAAAFILFFVIFAFTLIQWWLRKRWVYNED
>NC_006582.1|WP_011248421.1|3731321_3732155_-|carbohydrate-ABC-transporter-permease
MKINSVSTVVRYGLLTIISAIMLLPFIWMVTTSLKDPNQIFALPPTFIPNPIQWDSYLNVLSSTHFLRQMFNSIYIGATVTIGTVLLASLAGYAFARIPFKGRNVVFLAFLSVMMIPGEVTIIPLFLFMRELGWIDTHLPLMIIPIFGAGGAFGIFVMRQFFKQVPAELEDAARIDGCSRFRIFVQIMLPLSKPALATVTIFTFLTNWNEFLEPLIFINSRELMTLPLALSLFTDEAGTDWSSLMSASVLATLPVLTVFFFAQKQFIESLAMSGSKE
>NC_006582.1|WP_011248420.1|3729930_3731295_-|FAD-dependent-oxidoreductase
MRQVTEIEKQVRVRAEADVVVCGGGPAGIGAALSAARNGAKTILLESHGFLGGMGTAGMVTSFAYGYHDKERFITGGIFQEIRQKLHDRGGLIMTDRKGWEPFNAEQYKILAFELLAEAGVELLCHTTVVDTITKAGTIEAIIIESKAGREALLATHVIDATGDGDVAERAGAICKIGRDKDGGTQPSSLMYVLGNVDTAALGEKLDQEGRRGYWKTEDGYRYVNATGFADEIEQAKRDGFLTKVNRDHIAAIFTVPWVDNVVGINFGRIQGKNALDPQDLTDAEVIGREQVLDGIAFLKEYVPGFKRAELLQTAPQVGIRETRRIIGDYVITQEDIVELKQFDDCIAQSCYMIDIHSPDSSTTEIYKLPKGTHYDIPYRALLPQGLNNLLVAGRCISATHEALGSFRVQAICLAIGEAAGAAAAIATKEKCLPREIDVKHLQDTLVNQGAILS
>NC_006582.1|WP_011248419.1|3727317_3728643_+|6-phospho-alpha-glucosidase
MKTFNITIAGGGSTFTPGIILMLLDYLDEFPIDTIKLYDNDGDRQKTIADACAILLKERAPEVRLLASTNPEEAFTNIDFVMAHIRVGKYAMRELDEKIPLKHGVVGQETCGPGGIAYGMRSIPGVLELIDYMEKYSPEAWMLNYSNPAAIVAEATRKLRPHSKVLNICDMPIGIEELIAKNLGFASRKEMEVDYYGLNHFGWWTDIRDKNGLSLMPDVIKHVSQHGYATDGTSELEQQESWNSTLKKARDVQALDPETVPNTYLKYYLYPDYEVAHSNKEYTRANEVMEGREKFVFGECQAIIDKGTAKETKLVIDEHASYIVDLAKAIAFNTKERMLMIVENNGAIPNFDPTAMVEIPCLVGSNGPEKLVVGEIPRFQKSLMEQQVGVEKLVVEAFEEGSYQKLWQAITLSKTVPSAKVAKDILDDLIEANKAFWPALK
>NC_006582.1|WP_011248418.1|3725707_3727291_+|PTS-transporter-subunit-EIIC
MNAIKRFGSAMIVPVLLFAFFGIVVGLATLFKNPAIMGDIAAEGTMWYKVWSLIESGGWTIFNHMELAFVIGLPISLAKKAQARATLAALMVYLVFNNFINAILTLWPSTFGVDLSQGVENITGVKEIAGIPTLDTNIIGAIVISAVVIWIHNRFYDQKLPEMLGIFQGLVFVVIIGFFVMIPFAFLVAFVWPYVQQGIGSLQGFISQAGYVGVWLFHFLERVLIPTGLHHFIYTPFEFGPAAVNEGLKPYWIANLNDFATSTSALKDLYPYGFLLHGNIKMFGCLGIALAMYYSTPKENRKKVLALVLPATLTAIFAGITEPLEFTFLFIAPYLFVIHALLGATMVTLMNMFGVVGMMGGGLIEIAALNWIPLASNHGSIYIVQAMIGLIFAALYFVLFRWMIVKFDIPLPGRKKEEKARLYTKQDYQKVKKGSNSEKQAAATYESEYEEKAVYYLEGLGGKENIKDVTNCATRLRVTVIDPSLVKDSDYFTNNKMAHGLAKSGQSIQIIVGLSVPQVRDSFEAKL
>NC_006582.1|WP_011248428.1|3740577_3740991_-|hypothetical-protein
MTWHNQDPLNLSKEEWINLLQDEKVFNKIGLEMVFFVYKQPNYQSNATEIGEALGGVSQQQVTAWNRSIAKKIYQKLQKEPPFNSRGGKRYWNVLFDGAVERELDDKGNFIWKLRPSLVSALKRLGTSCNKTAKIES
>NC_006582.1|WP_041824839.1|3741785_3742076_-|CRISPR-associated-endonuclease-Cas2
MLVLITYDVQTSSLGGSKRLRKVAKACQNYGQRVQNSVFECIVDSAQLTSLKLELSSLIDKEKDSLRIYRLGNNYKSKVEHIGAKPTVDIEDPLIF
>NC_006582.1|WP_011248430.1|3742084_3743116_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MKKLLNTLYVTQPDTYLSLDGDNVVLLKEQEKLGRLPLHNLESIVSFGYTGASPALMGYCADRNISITFLTKNGRFLARVVGESRGNVVLRKTQYRISESEKESTNIARNFIIGKIYNNKWMLERMTREHPLRVDVEQFKSISQLLSTILQEVRSCDNLESLRGWEGQAAINYNKVFNQMILQQKDSFTFHGRSRRPPKDNVNAMLSFAYTLLANDAAAALETVGLDAYVGFMHQDRPGRASLALDLMEELRGIYADRFVLSLINRKEVTADDFYKKENGAVLMSDDARKSFLKAWQTKKQEKISHPYLGEKISWGLVPYAQALLLARFLRGDLDEYPPFLWK
>NC_006582.1|WP_041824141.1|3743112_3743772_-|CRISPR-associated-protein-Cas4
MVSKEEDRYLMLSGLQHFQFCKRQWALIHIEQQWEENVRTIEGQHLHKKADQPFIKEKRGSKLTVRAMPIQSKQLQISGICDVVEFVEDPDGVELSGVSGTYQAFPVEYKRGKPKKGDEDIVQLVAQAICLEEMLVCRIDKGYLFYNEIKHRVEVAITDSLREKVVEMAKEMHHYYDNRYTPKVKTGPFCKNCSLQHICLPKLMNKRSVKSYIEGRLSE
>NC_006582.1|WP_011248432.1|3743761_3744619_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSTLDHKIDFAVILSVSKANPNGDPLNGNRPRQNYDGHGEISDVAIKRKIRNRLQDMGEPVFVQSDDRKVDSHKSLRERADSNPELAKMLKAKNASSDDFAQIACEEWIDVRSFGQVFAFKGSNLSVGVRGPVSIHTATSIDPIDIVSTQITKSVNSVTGDKRSSDTMGMKHRVDFGVYVFKGSINTQLAEKTGFTNEDAEKIKQALVTLFENDSSSARPDGSMEVHKVYWWEHSSKLGQYSSAKVHRSLKVEAKTDSPKAFDEENYSVELSDLEGLSVEVLDGQ
>NC_006582.1|WP_011248433.1|3744615_3746499_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSWLLQLHQTYDDNLDQVGKTVKKGEDREYTLLPISHTTQNAHIEVTIDEDGDFLRAKALTKASTVIPCTEEAASRSGSKIAPYPLHDKLSYVAGDFVKYGGEIKNQDDVPFDTYIKNLAEWANSPYGTEKVKCIYTYLKKGRLIEDLVSEEVLVLDKNQQLLEKWDKSYEEQLGGKPAIFSSGATDQYSAFVRFNVFHPESIDDVWKDKQMFDSFIAFYNEKLGEEDICFVKGERLPSTERHANKIRHAADKAKLISANDNTGFTFRGRFKTSKEAVGISYEVSQKAHNALKWLIHRQGKTIDERVFLVWSNDNSPVPNPDDDAVDMMRHSNRELERDPETGQLFAKEVTKAIGGYRSDLKYQPEVNILVLDSATTGRMAVLYYRNLNKELYLDRLEEWHQFCAWEHRYKRDEKEFISFFGAPATKDIAFAAYGPRASDKVVKGLMERMLPCIVDKRPIPKDIVKSAFHRASNPVAMERWEWEKTLSITCALIRKMFIEKKEEWGVALDQHSKDRSYLFGRLLAVADVLERGALGKDETRATNAIRYMNSFAKNPSRTWKTIQESLQPYQAKLGTKSTYLSKLIDEISDQFDIDDFNNTPLTEKYLLGFYSQRRELYKKKEEEPNQ
>NC_006582.1|WP_011248434.1|3746500_3747211_-|type-I-C-CRISPR-associated-protein-Cas5
MKNEIQFEVFGDYALFTDPLTKIGGEKLSYSVPTYQALKGIVESIYWKPTIIFTIDKLRVMKPIQMESKGVRPIDYGGGNTLAHYTYLKDVHYQVKAHFDFNFNRPDLAFDRNEGKHYSILQRSLKAGGRRDIFLGTRECQGYVAPCEFGSGSGYYDGQGEYRLGTMVHGFNYPDETGQNQLDVRLWPAVMNDGYIKFPKPEDCTMIRPIKEMEPKEFKRDDIQSVEQLSYEVGGE
>NC_006582.1|WP_011248435.1|3747647_3750062_-|CRISPR-associated-helicase/endonuclease-Cas3
MYIAHVRETDKAKQTLKDHLLGASRIAEAHGAKLGLKHVAGLAGVLHDLGKFSDEFQDYLDKAVFHPELAEKKRGQVDHSTAGGKLLFGMLHNKENTFHEKLLAEIVGNAIISHHSNLQDYISPTIESNFLKRVLEKDLAEYGLAVERFFQEVVPKAEFTEYVTKAVEEIKQFTDNSPTQSFFLTKYIFSCLIDADRTDTRMFEEQAQEEERIQHRPLFEHYYQKLMNHLTSLKESSEAKQPINVLRSAMSDQCESFAKRPSGIYTLSIPTGGGKTLASLRYALKHAQEYEKQRIIYVVPFTTIIEQNAQEVRGILEDNENILEHHSNVIEEEYSESEFGDEQEDGMITKKERLKLARDNWDSPIIFTTLVQFLNVFYAKGNRNTRRLHNLSHSVLIFDEVQKVPTKCVSLFNEALNFLKKSAHCSILLCTATQPSLENVKHGLLKERDGEIVPNLTEVSEAFKRVEIINKTAKPMTNEELAEWIRAEATSWGSTLVILNTKSAVKNLYEKLKGGPLPVFHLSTSMCAAHRKEQLNEIRTLLQEGTPFICVTTQLIEAGIDVSFKCVIRSLAGLDSIAQAAGRCNRHGEDRLRYVYVIDHAEEKLSKLKEIEAGKWIAGNIFANFKKKAEKYEGNLLSQAAMREYFLYYYNRMDAELNYYVSKVDKEMTKLLMFHAKENSYVTHFQKKNGTAFPLLLNGSYKTAADHFRVIDQHTTSVIVPYGDGRDIIAQLNSDEWVDDLGKVLREAQQYTVNLYSQEIDQLKKENALVMHLDGMVYELKESWYHDKYGVDLKGEGGMEFTSW
>NC_006582.1|WP_011248436.1|3750381_3751062_-|amino-acid-racemase
MIGILAGMGPKSTGPFVDKTVDQCQKIYGAVNDIDFPHMMIYSCPTPFYIDKPLNHKDMEMAIINGAKRLEKTGVDFIAIPCNTAHVYFDQVKNSLSIPLLNMVEETIKRVPEHSKKVALLATIPTVQSGIFQEALAKEGYEFLHQDDWQTCINQIIEKIKQGQISESLELWDELYLQLADTIDTAIIACTDLNVVTDKSSGDISLVDSSTCLAEAIVHKYLSLKN
>NC_006582.1|WP_011248437.1|3752518_3754078_-|BCCT-family-transporter
MKSGPINKKRTMENKIVFPSILIIAIVSFLFAIYTEESTTLLNRIFDTIVDLFAWGYMWYALLMVVTGIWLAYSKYGQVVLGDPSEKPRYTLFEYASILVAMGVGATLMRTGMVQWSEVAVDPPFGLQAGSSEALLTGNAYSMFLWSFQTFAVFVMAAPAMAYILHVRKKPKMRISEACRVIFGDKFTDGLGGIVLDTLFLVSILAGAAVTLGLGTPIVTENLAELFNIEVTFLLTMIVTLIWVFVFTLSAYVGLDKGIKRLSTMNMYLAGVFALFIMIIGPGIFILDFFTDSVRVLVSRYLDFSLYTNSLHTEGGGSHIESHTVFWFAYNATWAMLHGVFAAVVSKGRTIKEMILTYLLAPTMLSWVATGILGGLGVERHTSGDVSVLNIVQEQEPVTAVPQILASIPIPEISIAVFIIIATIFLVTTLDSTTYTIATYMSTQDMSRRTPSRHLRIFVAVVITVLALTLMNIGGLAPLEVLSGLMGIPIIAIQILTIIAAKKMMDEDKAWINNVRKEK

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Crispr_ID: NC_006582_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006582_6

3741040-3741603

TypeI

NA:I-C

Consensus_repeat	Method
ATTTCAATCCACGCACTCATATAGAGTGCGAC	CRISPRCasFinder
CCACGCACTCACGAAGAGTGCGAC	CRT
ATTTCAACCCACGCACTCACGAAGAGTGCGAC	PILER-CR

8 spacers

cas2,cas1,cas4,cas7,cas8c,cas5,cas3

The CRISPR arrays of NC_006582_6

>merge|NC_006582|6|3741040-3741603|CRISPRCasFinder,CRT,PILER-CR
CTGTTTTTCCACGAAGTCATAAAGAGTGCGACAGGTACAAGCTGCTGCTACGATGGAGTGCTTAAAATTTCAATCCACGCACTCACGAAGAGTGCGACACATCGATCCAAAATCCTTCAAGACTTATAAAAGGATTTCAACCCACGCACTCACGAAGAGTGCGACTGACGTATGAAATACGCAGCACGTTCGCCACAAAAATTTCAACCCACGCACTCACGAAGAGTGCGACTTTGGCTTCTGCTTTAGTCTTAAAACCGCGTTTTATTTCAACCCACGCACTCACGAAGAGTGCGACCATAATAAGACGTAAGACATGCGGTGTCTCGTCGAATTTCAACCCACGCACTCACGAAGAGTGCGACCAGCTTTTCGAATGATACAGTAGTCAAGACCCACATTTCAACCCACGCACTCACGAAGAGTGCGACGGTACCGTCTTCTATTCCATTAGCGCATAATTCAGATTTCAATCCACGCACTCACGAAGAGTGCGACCAAAAAGTGGATTGTCTTTGTCTTTGTCTGAGTAATTTCAATCCACGCACTCACGAAGAGTGCGAC

>NC_006582|6|6|3741040-3741603|CRISPRCasFinder
CTGTTTTTCCACGAAGTCATAAAGAGTGCGAC	AGGTACAAGCTGCTGCTACGATGGAGTGCTTAAA
ATTTCAATCCACGCACTCACGAAGAGTGCGAC	ACATCGATCCAAAATCCTTCAAGACTTATAAAAGG
ATTTCAACCCACGCACTCACGAAGAGTGCGAC	TGACGTATGAAATACGCAGCACGTTCGCCACAAAA
ATTTCAACCCACGCACTCACGAAGAGTGCGAC	TTTGGCTTCTGCTTTAGTCTTAAAACCGCGTTTT
ATTTCAACCCACGCACTCACGAAGAGTGCGAC	CATAATAAGACGTAAGACATGCGGTGTCTCGTCGA
ATTTCAACCCACGCACTCACGAAGAGTGCGAC	CAGCTTTTCGAATGATACAGTAGTCAAGACCCAC
ATTTCAACCCACGCACTCACGAAGAGTGCGAC	GGTACCGTCTTCTATTCCATTAGCGCATAATTCAG
ATTTCAATCCACGCACTCACGAAGAGTGCGAC	CAAAAAGTGGATTGTCTTTGTCTTTGTCTGAGTA
ATTTCAATCCACGCACTCACGAAGAGTGCGAC

>NC_006582|6|5|3741048-3741603|CRT
CCACGAAGTCATAAAGAGTGCGAC	AGGTACAAGCTGCTGCTACGATGGAGTGCTTAAAATTTCAAT
CCACGCACTCACGAAGAGTGCGAC	ACATCGATCCAAAATCCTTCAAGACTTATAAAAGGATTTCAAC
CCACGCACTCACGAAGAGTGCGAC	TGACGTATGAAATACGCAGCACGTTCGCCACAAAAATTTCAAC
CCACGCACTCACGAAGAGTGCGAC	TTTGGCTTCTGCTTTAGTCTTAAAACCGCGTTTTATTTCAAC
CCACGCACTCACGAAGAGTGCGAC	CATAATAAGACGTAAGACATGCGGTGTCTCGTCGAATTTCAAC
CCACGCACTCACGAAGAGTGCGAC	CAGCTTTTCGAATGATACAGTAGTCAAGACCCACATTTCAAC
CCACGCACTCACGAAGAGTGCGAC	GGTACCGTCTTCTATTCCATTAGCGCATAATTCAGATTTCAAT
CCACGCACTCACGAAGAGTGCGAC	CAAAAAGTGGATTGTCTTTGTCTTTGTCTGAGTAATTTCAAT
CCACGCACTCACGAAGAGTGCGAC

>NC_006582|6|6|3741106-3741603|PILER-CR
ATTTCAATCCACGCACTCACGAAGAGTGCGAC	ACATCGATCCAAAATCCTTCAAGACTTATAAAAGG
ATTTCAACCCACGCACTCACGAAGAGTGCGAC	TGACGTATGAAATACGCAGCACGTTCGCCACAAAA
ATTTCAACCCACGCACTCACGAAGAGTGCGAC	TTTGGCTTCTGCTTTAGTCTTAAAACCGCGTTTT
ATTTCAACCCACGCACTCACGAAGAGTGCGAC	CATAATAAGACGTAAGACATGCGGTGTCTCGTCGA
ATTTCAACCCACGCACTCACGAAGAGTGCGAC	CAGCTTTTCGAATGATACAGTAGTCAAGACCCAC
ATTTCAACCCACGCACTCACGAAGAGTGCGAC	GGTACCGTCTTCTATTCCATTAGCGCATAATTCAG
ATTTCAATCCACGCACTCACGAAGAGTGCGAC	CAAAAAGTGGATTGTCTTTGTCTTTGTCTGAGTA
ATTTCAATCCACGCACTCACGAAGAGTGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_006582.1\|WP_011248432.1\|3743761_3744619_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|226175
NC_006582.1\|WP_011248426.1\|3736976_3738275_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350107
NC_006582.1\|WP_041824839.1\|3741785_3742076_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_006582.1\|WP_011248437.1\|3752518_3754078_-\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NC_006582.1\|WP_011248421.1\|3731321_3732155_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_006582.1\|WP_011248428.1\|3740577_3740991_-\|hypothetical-protein	unknown	unknown	unknown
NC_006582.1\|WP_011248430.1\|3742084_3743116_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NC_006582.1\|WP_011248434.1\|3746500_3747211_-\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|273847
NC_006582.1\|WP_011248423.1\|3733093_3734359_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NC_006582.1\|WP_011248433.1\|3744615_3746499_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	gnl\|CDD\|187887
NC_006582.1\|WP_142301323.1\|3732144_3733017_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NC_006582.1\|WP_041824141.1\|3743112_3743772_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|224385
NC_006582.1\|WP_011248436.1\|3750381_3751062_-\|amino-acid-racemase	unknown	unknown	gnl\|CDD\|224707
NC_006582.1\|WP_035203525.1\|3736203_3736920_-\|response-regulator	unknown	unknown	gnl\|CDD\|381091
NC_006582.1\|WP_011248420.1\|3729930_3731295_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NC_006582.1\|WP_011248427.1\|3738258_3738762_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350105
NC_006582.1\|WP_011248419.1\|3727317_3728643_+\|6-phospho-alpha-glucosidase	unknown	unknown	gnl\|CDD\|133434
NC_006582.1\|WP_152024052.1\|3754481_3754802_-\|hypothetical-protein	unknown	unknown	unknown
NC_006582.1\|WP_011248435.1\|3747647_3750062_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_006582.1\|WP_011248424.1\|3734449_3736183_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519

Protein	Function_ID	Function_description	E-value
NC_006582.1\|WP_011248432.1\|3743761_3744619_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|226175	COG3649, COG3649, CRISPR system related protein [Defense mechanisms].	7.08843e-145
NC_006582.1\|WP_011248426.1\|3736976_3738275_-\|hypothetical-protein	gnl\|CDD\|350107	cd08993, GH130, Glycosyl hydrolase family 130. This subfamily contains glycosyl hydrolase family 130 (GH130) proteins, as classified by the carbohydrate-active enzymes database (CAZY), are phosphorylases and hydrolases for beta-mannosides, and include beta-1,4-mannosylglucose phosphorylase (EC 2.4.1.281), beta-1,4-mannooligosaccharide phosphorylase (EC 2.4.1.319), among others that have yet to be characterized. They possess 5-bladed beta-propeller domains similar to families 32, 43, 62, 68, 117 (GH32, GH43, GH62, GH68, GH117). GH130 enzymes are involved in the bacterial utilization of mannans or N-linked glycans. Beta-1,4-mannosylglucose phosphorylase is involved in degradation of beta-1,4-D-mannosyl-N-acetyl-D-glucosamine linkages in the core of N-glycans; it produces alpha-mannose 1-phosphate and glucose from 4-O-beta-D-mannosyl-D-glucose and inorganic phosphate, using a critical catalytic Asp as a proton donor. This family includes Ruminococcus albus 4-O-beta-D-mannosyl-D-glucose phosphorylase (RaMP1) and beta-(1,4)-mannooligosaccharide phosphorylase (RaMP2), enzymes that phosphorolyze beta-mannosidic linkages at the non-reducing ends of their substrates, and have substantially diverse substrate specificity that are determined by three loop regions.	2.50971e-05
NC_006582.1\|WP_011248430.1\|3742084_3743116_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NC_006582.1\|WP_011248437.1\|3752518_3754078_-\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	3.30609e-146
NC_006582.1\|WP_011248421.1\|3731321_3732155_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.45871e-90
NC_006582.1\|WP_011248435.1\|3747647_3750062_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	2.77016e-125
NC_006582.1\|WP_011248434.1\|3746500_3747211_-\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|273847	TIGR01876, cas_Cas5d, CRISPR-associated protein Cas5, subtype I-C/DVULG. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum. This family belongs to a set of several Cas protein families, one each for a number of different CRISPR/Cas subtypes, that share a region of N-terminal sequence similarity modeled by TIGR02593. This family represents the Dvulg subtype of CRISPR/Cas locus.	3.75602e-116
NC_006582.1\|WP_011248423.1\|3733093_3734359_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.40995e-65
NC_006582.1\|WP_011248433.1\|3744615_3746499_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	0
NC_006582.1\|WP_142301323.1\|3732144_3733017_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.06172e-89
NC_006582.1\|WP_041824141.1\|3743112_3743772_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|224385	COG1468, COG1468, CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms].	2.73579e-37
NC_006582.1\|WP_035203525.1\|3736203_3736920_-\|response-regulator	gnl\|CDD\|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.02798e-53
NC_006582.1\|WP_011248420.1\|3729930_3731295_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	2.05904e-149
NC_006582.1\|WP_011248427.1\|3738258_3738762_-\|hypothetical-protein	gnl\|CDD\|350105	cd08991, GH43_HoAraf43-like, Glycosyl hydrolase family 43 protein such as Halothermothrix orenii H 168 alpha-L-arabinofuranosidase (HoAraf43;Hore_20580). This glycosyl hydrolase family 43 (GH43) subgroup includes Halothermothrix orenii H 168 alpha-L-arabinofuranosidase (EC 3.2.1.55) (HoAraf43;Hore_20580). It belongs to the glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) which includes family 43 (GH43) and 62 (GH62) families. This GH43_ HoAraf43-like subgroup includes enzymes that have been annotated as having xylan-digesting beta-xylosidase (EC 3.2.1.37) and xylanase (endo-alpha-L-arabinanase, EC 3.2.1.8) activities. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	3.46484e-06
NC_006582.1\|WP_011248419.1\|3727317_3728643_+\|6-phospho-alpha-glucosidase	gnl\|CDD\|133434	cd05298, GH4_GlvA_pagL_like, Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases. Bacillus subtilis GlvA and Clostridium acetobutylicum pagL are 6-phospho-alpha-glucosidase, catalyzing the hydrolysis of alpha-glucopyranoside bonds to release glucose from oligosaccharides. The substrate specificities of other members of this subgroup are unknown. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP_PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases, which include 6-phospho-beta-glucosidases, 6-phospho-alpha-glucosidases, alpha-glucosidases/alpha-glucuronidases (only from Thermotoga), and alpha-galactosidases. Members of this subfamily are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NC_006582.1\|WP_011248436.1\|3750381_3751062_-\|amino-acid-racemase	gnl\|CDD\|224707	COG1794, RacX, Aspartate racemase [Cell envelope biogenesis, outer membrane].	9.40651e-62
NC_006582.1\|WP_041824839.1\|3741785_3742076_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	6.6055e-35
NC_006582.1\|WP_011248424.1\|3734449_3736183_-\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	3.40827e-55

>NC_006582.1|WP_011248428.1|3740577_3740991_-|hypothetical-protein
MTWHNQDPLNLSKEEWINLLQDEKVFNKIGLEMVFFVYKQPNYQSNATEIGEALGGVSQQQVTAWNRSIAKKIYQKLQKEPPFNSRGGKRYWNVLFDGAVERELDDKGNFIWKLRPSLVSALKRLGTSCNKTAKIES
>NC_006582.1|WP_011248427.1|3738258_3738762_-|hypothetical-protein
MKSPLKALTVSVILLLAGLVLGDDRMEAHELPLFHFEKTLIEPSEMRYNPTGEVDFPTVIRAADYFENPLGTYYMYYGPHDAPGGIALAYADSVTGPWTEYASNPVISRNWQPHYNVSHVASAHPIWNEEEGKLFLYFHGENSVTRLASSEDGIHFDYEQVVIDTSD
>NC_006582.1|WP_011248426.1|3736976_3738275_-|hypothetical-protein
MTRLISEASYARVFEHELDGKDNRYVMLLMGNNNGTRRIYLAWSDDGREWEAQQEPLISPQPGQGGNLSGAYYFPYNGHHYVTVHGGSGNQYVVDVGENFDQEIHLGPYYQPSAVAPENGRAASRSYIYSEDELYMVYEAGQRGSTKIALARAILGDERVEMASASLRLPSRVVSTNSEIDFEVLARRYDGTTIAENELSFSLFSSDSSVVRVDGQRLYSGGEGIAEVRAEVSYQGKVITTEAISIEVRDGEVWNVIDERFDDYTRRWQIAKGSAAQGTIEQGAGFVDIIENRRSGGAYHYLTYEGFYLPNSFYTLEAELSVFAPSQGNEISIREGNRQKSLFITYDGKQGFIQDRLLQPTVAVEIDPTERARYKLVSTGQTTYDVYRNDEFLFRSTSVSQAGQNLVKVGADSQGSAALRVDALRIQTNTAP
>NC_006582.1|WP_035203525.1|3736203_3736920_-|response-regulator
MYKVVIAEDEKMIRKGLVTIVDQLVTDFTVIGEADNGERALELLAHDCPDVLLTDIRMPKCDGLSLIREARSYYPHVKIVIVSGHEEFAYAQQAIQHGVSRYLLKPIDRTEVVLAFDEIKRGLVEPEQEDHENHLIQQVDSYIKTHIDQDITLQAVAKLVHLHPTYFSQWFKNETGQNFSTYVTQKRLERAETLLHQTNLRVYEVARMSGYQNEKHFMKLFKKEKRCTPTQFRQRALL
>NC_006582.1|WP_011248424.1|3734449_3736183_-|sensor-histidine-kinase
MSLRPKIILLFLSIVLVPLNLLGMITYAYFSKTLEDQTYHYTVQVIGQVNQNVNAYIDEMHRLSLLPLYDRDILAILKNRSDVHHSYYPQTEEFERMSSFLSTLSYNRQELSGIHIITRDGSLFSDLGSPRTVHRLAEGTSDWQEAIEAGNGASLLLPTHSPSYVLGAEKSVFSVGRLLRDPDGFRPLGMIKVDIELSFIESLLEDVDLSEDASITMIDRNGEPIYETGKAIYPLLKGKGEDVWQLAERESIAVDGVDYLPVIRNDSSGDVQTIVFLPEHHIVGASQSLRLFTIGLMLAVSAVVIMLALVAERSLTKPIFELRQVMALAEKGEFHHRMNRSSKDELGQLAIGFNHMMKQINELIAKVYQTEIREKDAEIKALQTQMNPHFIYNTLEHINMMAITKQAYELSDMVASLGRLIRYSIDQKTRFVPLREELAFVESYITIQQKRLEGKVTFSIAVPEAMRSLSIPKLILQPLIENAIEHGHQHGEWPGEISIKGWQDDAYSYIEVRDSGQGMKQETIERMKEEPERGAGNQVALGNISERLLLLLGEQARLMIDSELGRGTKVTVRLPKT
>NC_006582.1|WP_011248423.1|3733093_3734359_-|sugar-ABC-transporter-substrate-binding-protein
MKRWSISAGLLLVVAGCSSSGGSTDANGDEQIELTFSTWGNENHIAVYEELLEAYYVDHPNVHVTIQTTPFPDYQQNMTVLAAGQELPDIGWAAERMVPQFIENNILADLSALREDESFHFEDILPGTITQYEVGDALYGVPFSSPPHIIFYNKTLFEKNGLETPQELESRGEWTWEAFEEAAAVIAEEEGVYGANFFRAWETWENLLAHTRAEGGDLFNEDTTEFTWNSDAGISTLEMLERMMFEDRSHPRAGDQVAFEAGNVGMFFDVYSYVSTAREIEDFEWDIAPVPLGSQGRSPILGQAGYVMFEGTEHPEEALDLIRYFASQTGMEATSTYFAPPRASVLESDAFIEQPGNPPRASMESTILNLSEESRVLPIHPEWQNIDNHILQGFDHLFGQTAEPADILEQMEASINPLVQE
>NC_006582.1|WP_142301323.1|3732144_3733017_-|ABC-transporter-permease-subunit
MFKRDELAGWLFISPMLLGFTIFMFIPIGFAFYMSFTDWPLLGQSEFIGTANYQAIVQDPEFQQVMKNTVLFTAGLVPFNIILALGLALLLRHPLPGMGLFRTIVFVPVVTTLVVWAIVWRYMFATDFGFINSILAWFGIESQAWLYNKNLAMPVVILTSVLKNVGLNMVLFLAALQMVPKNLYEAARIDGAGSWRQFKNITLPIISPTVFLATIITIIGAMKIFAQIFVMTKGGPESSTKVIVYYIWEKAFRLFDMGYASAAAFILFFVIFAFTLIQWWLRKRWVYNED
>NC_006582.1|WP_011248421.1|3731321_3732155_-|carbohydrate-ABC-transporter-permease
MKINSVSTVVRYGLLTIISAIMLLPFIWMVTTSLKDPNQIFALPPTFIPNPIQWDSYLNVLSSTHFLRQMFNSIYIGATVTIGTVLLASLAGYAFARIPFKGRNVVFLAFLSVMMIPGEVTIIPLFLFMRELGWIDTHLPLMIIPIFGAGGAFGIFVMRQFFKQVPAELEDAARIDGCSRFRIFVQIMLPLSKPALATVTIFTFLTNWNEFLEPLIFINSRELMTLPLALSLFTDEAGTDWSSLMSASVLATLPVLTVFFFAQKQFIESLAMSGSKE
>NC_006582.1|WP_011248420.1|3729930_3731295_-|FAD-dependent-oxidoreductase
MRQVTEIEKQVRVRAEADVVVCGGGPAGIGAALSAARNGAKTILLESHGFLGGMGTAGMVTSFAYGYHDKERFITGGIFQEIRQKLHDRGGLIMTDRKGWEPFNAEQYKILAFELLAEAGVELLCHTTVVDTITKAGTIEAIIIESKAGREALLATHVIDATGDGDVAERAGAICKIGRDKDGGTQPSSLMYVLGNVDTAALGEKLDQEGRRGYWKTEDGYRYVNATGFADEIEQAKRDGFLTKVNRDHIAAIFTVPWVDNVVGINFGRIQGKNALDPQDLTDAEVIGREQVLDGIAFLKEYVPGFKRAELLQTAPQVGIRETRRIIGDYVITQEDIVELKQFDDCIAQSCYMIDIHSPDSSTTEIYKLPKGTHYDIPYRALLPQGLNNLLVAGRCISATHEALGSFRVQAICLAIGEAAGAAAAIATKEKCLPREIDVKHLQDTLVNQGAILS
>NC_006582.1|WP_011248419.1|3727317_3728643_+|6-phospho-alpha-glucosidase
MKTFNITIAGGGSTFTPGIILMLLDYLDEFPIDTIKLYDNDGDRQKTIADACAILLKERAPEVRLLASTNPEEAFTNIDFVMAHIRVGKYAMRELDEKIPLKHGVVGQETCGPGGIAYGMRSIPGVLELIDYMEKYSPEAWMLNYSNPAAIVAEATRKLRPHSKVLNICDMPIGIEELIAKNLGFASRKEMEVDYYGLNHFGWWTDIRDKNGLSLMPDVIKHVSQHGYATDGTSELEQQESWNSTLKKARDVQALDPETVPNTYLKYYLYPDYEVAHSNKEYTRANEVMEGREKFVFGECQAIIDKGTAKETKLVIDEHASYIVDLAKAIAFNTKERMLMIVENNGAIPNFDPTAMVEIPCLVGSNGPEKLVVGEIPRFQKSLMEQQVGVEKLVVEAFEEGSYQKLWQAITLSKTVPSAKVAKDILDDLIEANKAFWPALK
>NC_006582.1|WP_041824839.1|3741785_3742076_-|CRISPR-associated-endonuclease-Cas2
MLVLITYDVQTSSLGGSKRLRKVAKACQNYGQRVQNSVFECIVDSAQLTSLKLELSSLIDKEKDSLRIYRLGNNYKSKVEHIGAKPTVDIEDPLIF
>NC_006582.1|WP_011248430.1|3742084_3743116_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MKKLLNTLYVTQPDTYLSLDGDNVVLLKEQEKLGRLPLHNLESIVSFGYTGASPALMGYCADRNISITFLTKNGRFLARVVGESRGNVVLRKTQYRISESEKESTNIARNFIIGKIYNNKWMLERMTREHPLRVDVEQFKSISQLLSTILQEVRSCDNLESLRGWEGQAAINYNKVFNQMILQQKDSFTFHGRSRRPPKDNVNAMLSFAYTLLANDAAAALETVGLDAYVGFMHQDRPGRASLALDLMEELRGIYADRFVLSLINRKEVTADDFYKKENGAVLMSDDARKSFLKAWQTKKQEKISHPYLGEKISWGLVPYAQALLLARFLRGDLDEYPPFLWK
>NC_006582.1|WP_041824141.1|3743112_3743772_-|CRISPR-associated-protein-Cas4
MVSKEEDRYLMLSGLQHFQFCKRQWALIHIEQQWEENVRTIEGQHLHKKADQPFIKEKRGSKLTVRAMPIQSKQLQISGICDVVEFVEDPDGVELSGVSGTYQAFPVEYKRGKPKKGDEDIVQLVAQAICLEEMLVCRIDKGYLFYNEIKHRVEVAITDSLREKVVEMAKEMHHYYDNRYTPKVKTGPFCKNCSLQHICLPKLMNKRSVKSYIEGRLSE
>NC_006582.1|WP_011248432.1|3743761_3744619_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSTLDHKIDFAVILSVSKANPNGDPLNGNRPRQNYDGHGEISDVAIKRKIRNRLQDMGEPVFVQSDDRKVDSHKSLRERADSNPELAKMLKAKNASSDDFAQIACEEWIDVRSFGQVFAFKGSNLSVGVRGPVSIHTATSIDPIDIVSTQITKSVNSVTGDKRSSDTMGMKHRVDFGVYVFKGSINTQLAEKTGFTNEDAEKIKQALVTLFENDSSSARPDGSMEVHKVYWWEHSSKLGQYSSAKVHRSLKVEAKTDSPKAFDEENYSVELSDLEGLSVEVLDGQ
>NC_006582.1|WP_011248433.1|3744615_3746499_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSWLLQLHQTYDDNLDQVGKTVKKGEDREYTLLPISHTTQNAHIEVTIDEDGDFLRAKALTKASTVIPCTEEAASRSGSKIAPYPLHDKLSYVAGDFVKYGGEIKNQDDVPFDTYIKNLAEWANSPYGTEKVKCIYTYLKKGRLIEDLVSEEVLVLDKNQQLLEKWDKSYEEQLGGKPAIFSSGATDQYSAFVRFNVFHPESIDDVWKDKQMFDSFIAFYNEKLGEEDICFVKGERLPSTERHANKIRHAADKAKLISANDNTGFTFRGRFKTSKEAVGISYEVSQKAHNALKWLIHRQGKTIDERVFLVWSNDNSPVPNPDDDAVDMMRHSNRELERDPETGQLFAKEVTKAIGGYRSDLKYQPEVNILVLDSATTGRMAVLYYRNLNKELYLDRLEEWHQFCAWEHRYKRDEKEFISFFGAPATKDIAFAAYGPRASDKVVKGLMERMLPCIVDKRPIPKDIVKSAFHRASNPVAMERWEWEKTLSITCALIRKMFIEKKEEWGVALDQHSKDRSYLFGRLLAVADVLERGALGKDETRATNAIRYMNSFAKNPSRTWKTIQESLQPYQAKLGTKSTYLSKLIDEISDQFDIDDFNNTPLTEKYLLGFYSQRRELYKKKEEEPNQ
>NC_006582.1|WP_011248434.1|3746500_3747211_-|type-I-C-CRISPR-associated-protein-Cas5
MKNEIQFEVFGDYALFTDPLTKIGGEKLSYSVPTYQALKGIVESIYWKPTIIFTIDKLRVMKPIQMESKGVRPIDYGGGNTLAHYTYLKDVHYQVKAHFDFNFNRPDLAFDRNEGKHYSILQRSLKAGGRRDIFLGTRECQGYVAPCEFGSGSGYYDGQGEYRLGTMVHGFNYPDETGQNQLDVRLWPAVMNDGYIKFPKPEDCTMIRPIKEMEPKEFKRDDIQSVEQLSYEVGGE
>NC_006582.1|WP_011248435.1|3747647_3750062_-|CRISPR-associated-helicase/endonuclease-Cas3
MYIAHVRETDKAKQTLKDHLLGASRIAEAHGAKLGLKHVAGLAGVLHDLGKFSDEFQDYLDKAVFHPELAEKKRGQVDHSTAGGKLLFGMLHNKENTFHEKLLAEIVGNAIISHHSNLQDYISPTIESNFLKRVLEKDLAEYGLAVERFFQEVVPKAEFTEYVTKAVEEIKQFTDNSPTQSFFLTKYIFSCLIDADRTDTRMFEEQAQEEERIQHRPLFEHYYQKLMNHLTSLKESSEAKQPINVLRSAMSDQCESFAKRPSGIYTLSIPTGGGKTLASLRYALKHAQEYEKQRIIYVVPFTTIIEQNAQEVRGILEDNENILEHHSNVIEEEYSESEFGDEQEDGMITKKERLKLARDNWDSPIIFTTLVQFLNVFYAKGNRNTRRLHNLSHSVLIFDEVQKVPTKCVSLFNEALNFLKKSAHCSILLCTATQPSLENVKHGLLKERDGEIVPNLTEVSEAFKRVEIINKTAKPMTNEELAEWIRAEATSWGSTLVILNTKSAVKNLYEKLKGGPLPVFHLSTSMCAAHRKEQLNEIRTLLQEGTPFICVTTQLIEAGIDVSFKCVIRSLAGLDSIAQAAGRCNRHGEDRLRYVYVIDHAEEKLSKLKEIEAGKWIAGNIFANFKKKAEKYEGNLLSQAAMREYFLYYYNRMDAELNYYVSKVDKEMTKLLMFHAKENSYVTHFQKKNGTAFPLLLNGSYKTAADHFRVIDQHTTSVIVPYGDGRDIIAQLNSDEWVDDLGKVLREAQQYTVNLYSQEIDQLKKENALVMHLDGMVYELKESWYHDKYGVDLKGEGGMEFTSW
>NC_006582.1|WP_011248436.1|3750381_3751062_-|amino-acid-racemase
MIGILAGMGPKSTGPFVDKTVDQCQKIYGAVNDIDFPHMMIYSCPTPFYIDKPLNHKDMEMAIINGAKRLEKTGVDFIAIPCNTAHVYFDQVKNSLSIPLLNMVEETIKRVPEHSKKVALLATIPTVQSGIFQEALAKEGYEFLHQDDWQTCINQIIEKIKQGQISESLELWDELYLQLADTIDTAIIACTDLNVVTDKSSGDISLVDSSTCLAEAIVHKYLSLKN
>NC_006582.1|WP_011248437.1|3752518_3754078_-|BCCT-family-transporter
MKSGPINKKRTMENKIVFPSILIIAIVSFLFAIYTEESTTLLNRIFDTIVDLFAWGYMWYALLMVVTGIWLAYSKYGQVVLGDPSEKPRYTLFEYASILVAMGVGATLMRTGMVQWSEVAVDPPFGLQAGSSEALLTGNAYSMFLWSFQTFAVFVMAAPAMAYILHVRKKPKMRISEACRVIFGDKFTDGLGGIVLDTLFLVSILAGAAVTLGLGTPIVTENLAELFNIEVTFLLTMIVTLIWVFVFTLSAYVGLDKGIKRLSTMNMYLAGVFALFIMIIGPGIFILDFFTDSVRVLVSRYLDFSLYTNSLHTEGGGSHIESHTVFWFAYNATWAMLHGVFAAVVSKGRTIKEMILTYLLAPTMLSWVATGILGGLGVERHTSGDVSVLNIVQEQEPVTAVPQILASIPIPEISIAVFIIIATIFLVTTLDSTTYTIATYMSTQDMSRRTPSRHLRIFVAVVITVLALTLMNIGGLAPLEVLSGLMGIPIIAIQILTIIAAKKMMDEDKAWINNVRKEK
>NC_006582.1|WP_152024052.1|3754481_3754802_-|hypothetical-protein
MEVDAPDGALVLYPTELEELREKEGKHFLFFITTDEDQTGYIVTSKPDNEGPGLLFPIQEEFDACSELFLAIPLPLSHSDSFVYKEASSYEEMTEAIEIAKNERKR

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Crispr_ID: NC_006582_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006582_7

3751899-3752130

TypeI

I-C

Consensus_repeat	Method
ATTTCAATCCACGCACTCACAAAGAGTGCGAT	PILER-CR
ATTTCAATCCACGCACTCACAAAGAGTGCGAT	CRISPRCasFinder
ATTTCAATCCACGCACTCACAAAGAGTGCGAT	CRT

3 spacers

cas3,cas5,cas8c,cas7,cas4,cas1,cas2

The CRISPR arrays of NC_006582_7

>merge|NC_006582|7|3751899-3752130|PILER-CR,CRISPRCasFinder,CRT
ATTTCAATCCACGCACTCACAAAGAGTGCGACCGGACGACATATTGATTTCCATGGTGCAAGTATGATTTCAATCCACGCACTCACAAAGAGTGCGATAAAATAGAATCGATTTGCGTTTTAGGAGACGCCGCATTTCAATCCACGCACTCACAAAGAGTGCGATGGGTATCTACCACTATATCATTTATGGAAAGATGAATTTCAATCCACGCACTCACAAAGAGTGCGAT

>NC_006582|7|7|3751899-3752130|PILER-CR
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CGGACGACATATTGATTTCCATGGTGCAAGTATG
ATTTCAATCCACGCACTCACAAAGAGTGCGAT	AAAATAGAATCGATTTGCGTTTTAGGAGACGCCGC
ATTTCAATCCACGCACTCACAAAGAGTGCGAT	GGGTATCTACCACTATATCATTTATGGAAAGATGA
ATTTCAATCCACGCACTCACAAAGAGTGCGAT

>NC_006582|7|7|3751899-3752130|CRISPRCasFinder
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CGGACGACATATTGATTTCCATGGTGCAAGTATG
ATTTCAATCCACGCACTCACAAAGAGTGCGAT	AAAATAGAATCGATTTGCGTTTTAGGAGACGCCGC
ATTTCAATCCACGCACTCACAAAGAGTGCGAT	GGGTATCTACCACTATATCATTTATGGAAAGATGA
ATTTCAATCCACGCACTCACAAAGAGTGCGAT

>NC_006582|7|6|3751899-3752130|CRT
ATTTCAATCCACGCACTCACAAAGAGTGCGAC	CGGACGACATATTGATTTCCATGGTGCAAGTATG
ATTTCAATCCACGCACTCACAAAGAGTGCGAT	AAAATAGAATCGATTTGCGTTTTAGGAGACGCCGC
ATTTCAATCCACGCACTCACAAAGAGTGCGAT	GGGTATCTACCACTATATCATTTATGGAAAGATGA
ATTTCAATCCACGCACTCACAAAGAGTGCGAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_006582.1\|WP_011248445.1\|3761410_3762316_-\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|188630
NC_006582.1\|WP_011248442.1\|3758431_3759913_-\|tripartite-tricarboxylate-transporter-permease	unknown	unknown	gnl\|CDD\|225870
NC_006582.1\|WP_041824839.1\|3741785_3742076_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_006582.1\|WP_011248430.1\|3742084_3743116_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NC_006582.1\|WP_011248428.1\|3740577_3740991_-\|hypothetical-protein	unknown	unknown	unknown
NC_006582.1\|WP_011248434.1\|3746500_3747211_-\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|273847
NC_006582.1\|WP_041824141.1\|3743112_3743772_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|224385
NC_006582.1\|WP_011248441.1\|3757536_3758412_+\|ribokinase	unknown	unknown	gnl\|CDD\|238579
NC_006582.1\|WP_011248436.1\|3750381_3751062_-\|amino-acid-racemase	unknown	unknown	gnl\|CDD\|224707
NC_006582.1\|WP_011248443.1\|3759926_3760361_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl\|CDD\|377815
NC_006582.1\|WP_011248432.1\|3743761_3744619_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|226175
NC_006582.1\|WP_011248439.1\|3755328_3755799_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227027
NC_006582.1\|WP_011248444.1\|3760372_3761344_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NC_006582.1\|WP_011248440.1\|3756328_3757339_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_006582.1\|WP_011248437.1\|3752518_3754078_-\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NC_006582.1\|WP_011248427.1\|3738258_3738762_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350105
NC_006582.1\|WP_152024052.1\|3754481_3754802_-\|hypothetical-protein	unknown	unknown	unknown
NC_006582.1\|WP_011248435.1\|3747647_3750062_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_006582.1\|WP_011248433.1\|3744615_3746499_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	gnl\|CDD\|187887
NC_006582.1\|WP_011248446.1\|3762929_3763886_-\|class-II-fructose-bisphosphatase	unknown	unknown	gnl\|CDD\|236536

Protein	Function_ID	Function_description	E-value
NC_006582.1\|WP_011248445.1\|3761410_3762316_-\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	1.30927e-92
NC_006582.1\|WP_011248442.1\|3758431_3759913_-\|tripartite-tricarboxylate-transporter-permease	gnl\|CDD\|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	5.35888e-154
NC_006582.1\|WP_041824839.1\|3741785_3742076_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	6.6055e-35
NC_006582.1\|WP_011248430.1\|3742084_3743116_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NC_006582.1\|WP_011248435.1\|3747647_3750062_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	2.77016e-125
NC_006582.1\|WP_011248434.1\|3746500_3747211_-\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|273847	TIGR01876, cas_Cas5d, CRISPR-associated protein Cas5, subtype I-C/DVULG. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum. This family belongs to a set of several Cas protein families, one each for a number of different CRISPR/Cas subtypes, that share a region of N-terminal sequence similarity modeled by TIGR02593. This family represents the Dvulg subtype of CRISPR/Cas locus.	3.75602e-116
NC_006582.1\|WP_041824141.1\|3743112_3743772_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|224385	COG1468, COG1468, CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms].	2.73579e-37
NC_006582.1\|WP_011248441.1\|3757536_3758412_+\|ribokinase	gnl\|CDD\|238579	cd01174, ribokinase, Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.	7.66425e-119
NC_006582.1\|WP_011248433.1\|3744615_3746499_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	0
NC_006582.1\|WP_011248443.1\|3759926_3760361_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	0.000805338
NC_006582.1\|WP_011248432.1\|3743761_3744619_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|226175	COG3649, COG3649, CRISPR system related protein [Defense mechanisms].	7.08843e-145
NC_006582.1\|WP_011248439.1\|3755328_3755799_+\|hypothetical-protein	gnl\|CDD\|227027	COG4682, COG4682, Predicted membrane protein [Function unknown].	3.14633e-46
NC_006582.1\|WP_011248444.1\|3760372_3761344_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.36444e-107
NC_006582.1\|WP_011248440.1\|3756328_3757339_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.24147e-100
NC_006582.1\|WP_011248437.1\|3752518_3754078_-\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	3.30609e-146
NC_006582.1\|WP_011248427.1\|3738258_3738762_-\|hypothetical-protein	gnl\|CDD\|350105	cd08991, GH43_HoAraf43-like, Glycosyl hydrolase family 43 protein such as Halothermothrix orenii H 168 alpha-L-arabinofuranosidase (HoAraf43;Hore_20580). This glycosyl hydrolase family 43 (GH43) subgroup includes Halothermothrix orenii H 168 alpha-L-arabinofuranosidase (EC 3.2.1.55) (HoAraf43;Hore_20580). It belongs to the glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) which includes family 43 (GH43) and 62 (GH62) families. This GH43_ HoAraf43-like subgroup includes enzymes that have been annotated as having xylan-digesting beta-xylosidase (EC 3.2.1.37) and xylanase (endo-alpha-L-arabinanase, EC 3.2.1.8) activities. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	3.46484e-06
NC_006582.1\|WP_011248436.1\|3750381_3751062_-\|amino-acid-racemase	gnl\|CDD\|224707	COG1794, RacX, Aspartate racemase [Cell envelope biogenesis, outer membrane].	9.40651e-62
NC_006582.1\|WP_011248446.1\|3762929_3763886_-\|class-II-fructose-bisphosphatase	gnl\|CDD\|236536	PRK09479, glpX, fructose 1,6-bisphosphatase II; Reviewed.	1.23321e-166

>NC_006582.1|WP_011248436.1|3750381_3751062_-|amino-acid-racemase
MIGILAGMGPKSTGPFVDKTVDQCQKIYGAVNDIDFPHMMIYSCPTPFYIDKPLNHKDMEMAIINGAKRLEKTGVDFIAIPCNTAHVYFDQVKNSLSIPLLNMVEETIKRVPEHSKKVALLATIPTVQSGIFQEALAKEGYEFLHQDDWQTCINQIIEKIKQGQISESLELWDELYLQLADTIDTAIIACTDLNVVTDKSSGDISLVDSSTCLAEAIVHKYLSLKN
>NC_006582.1|WP_011248435.1|3747647_3750062_-|CRISPR-associated-helicase/endonuclease-Cas3
MYIAHVRETDKAKQTLKDHLLGASRIAEAHGAKLGLKHVAGLAGVLHDLGKFSDEFQDYLDKAVFHPELAEKKRGQVDHSTAGGKLLFGMLHNKENTFHEKLLAEIVGNAIISHHSNLQDYISPTIESNFLKRVLEKDLAEYGLAVERFFQEVVPKAEFTEYVTKAVEEIKQFTDNSPTQSFFLTKYIFSCLIDADRTDTRMFEEQAQEEERIQHRPLFEHYYQKLMNHLTSLKESSEAKQPINVLRSAMSDQCESFAKRPSGIYTLSIPTGGGKTLASLRYALKHAQEYEKQRIIYVVPFTTIIEQNAQEVRGILEDNENILEHHSNVIEEEYSESEFGDEQEDGMITKKERLKLARDNWDSPIIFTTLVQFLNVFYAKGNRNTRRLHNLSHSVLIFDEVQKVPTKCVSLFNEALNFLKKSAHCSILLCTATQPSLENVKHGLLKERDGEIVPNLTEVSEAFKRVEIINKTAKPMTNEELAEWIRAEATSWGSTLVILNTKSAVKNLYEKLKGGPLPVFHLSTSMCAAHRKEQLNEIRTLLQEGTPFICVTTQLIEAGIDVSFKCVIRSLAGLDSIAQAAGRCNRHGEDRLRYVYVIDHAEEKLSKLKEIEAGKWIAGNIFANFKKKAEKYEGNLLSQAAMREYFLYYYNRMDAELNYYVSKVDKEMTKLLMFHAKENSYVTHFQKKNGTAFPLLLNGSYKTAADHFRVIDQHTTSVIVPYGDGRDIIAQLNSDEWVDDLGKVLREAQQYTVNLYSQEIDQLKKENALVMHLDGMVYELKESWYHDKYGVDLKGEGGMEFTSW
>NC_006582.1|WP_011248434.1|3746500_3747211_-|type-I-C-CRISPR-associated-protein-Cas5
MKNEIQFEVFGDYALFTDPLTKIGGEKLSYSVPTYQALKGIVESIYWKPTIIFTIDKLRVMKPIQMESKGVRPIDYGGGNTLAHYTYLKDVHYQVKAHFDFNFNRPDLAFDRNEGKHYSILQRSLKAGGRRDIFLGTRECQGYVAPCEFGSGSGYYDGQGEYRLGTMVHGFNYPDETGQNQLDVRLWPAVMNDGYIKFPKPEDCTMIRPIKEMEPKEFKRDDIQSVEQLSYEVGGE
>NC_006582.1|WP_011248433.1|3744615_3746499_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSWLLQLHQTYDDNLDQVGKTVKKGEDREYTLLPISHTTQNAHIEVTIDEDGDFLRAKALTKASTVIPCTEEAASRSGSKIAPYPLHDKLSYVAGDFVKYGGEIKNQDDVPFDTYIKNLAEWANSPYGTEKVKCIYTYLKKGRLIEDLVSEEVLVLDKNQQLLEKWDKSYEEQLGGKPAIFSSGATDQYSAFVRFNVFHPESIDDVWKDKQMFDSFIAFYNEKLGEEDICFVKGERLPSTERHANKIRHAADKAKLISANDNTGFTFRGRFKTSKEAVGISYEVSQKAHNALKWLIHRQGKTIDERVFLVWSNDNSPVPNPDDDAVDMMRHSNRELERDPETGQLFAKEVTKAIGGYRSDLKYQPEVNILVLDSATTGRMAVLYYRNLNKELYLDRLEEWHQFCAWEHRYKRDEKEFISFFGAPATKDIAFAAYGPRASDKVVKGLMERMLPCIVDKRPIPKDIVKSAFHRASNPVAMERWEWEKTLSITCALIRKMFIEKKEEWGVALDQHSKDRSYLFGRLLAVADVLERGALGKDETRATNAIRYMNSFAKNPSRTWKTIQESLQPYQAKLGTKSTYLSKLIDEISDQFDIDDFNNTPLTEKYLLGFYSQRRELYKKKEEEPNQ
>NC_006582.1|WP_011248432.1|3743761_3744619_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSTLDHKIDFAVILSVSKANPNGDPLNGNRPRQNYDGHGEISDVAIKRKIRNRLQDMGEPVFVQSDDRKVDSHKSLRERADSNPELAKMLKAKNASSDDFAQIACEEWIDVRSFGQVFAFKGSNLSVGVRGPVSIHTATSIDPIDIVSTQITKSVNSVTGDKRSSDTMGMKHRVDFGVYVFKGSINTQLAEKTGFTNEDAEKIKQALVTLFENDSSSARPDGSMEVHKVYWWEHSSKLGQYSSAKVHRSLKVEAKTDSPKAFDEENYSVELSDLEGLSVEVLDGQ
>NC_006582.1|WP_041824141.1|3743112_3743772_-|CRISPR-associated-protein-Cas4
MVSKEEDRYLMLSGLQHFQFCKRQWALIHIEQQWEENVRTIEGQHLHKKADQPFIKEKRGSKLTVRAMPIQSKQLQISGICDVVEFVEDPDGVELSGVSGTYQAFPVEYKRGKPKKGDEDIVQLVAQAICLEEMLVCRIDKGYLFYNEIKHRVEVAITDSLREKVVEMAKEMHHYYDNRYTPKVKTGPFCKNCSLQHICLPKLMNKRSVKSYIEGRLSE
>NC_006582.1|WP_011248430.1|3742084_3743116_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MKKLLNTLYVTQPDTYLSLDGDNVVLLKEQEKLGRLPLHNLESIVSFGYTGASPALMGYCADRNISITFLTKNGRFLARVVGESRGNVVLRKTQYRISESEKESTNIARNFIIGKIYNNKWMLERMTREHPLRVDVEQFKSISQLLSTILQEVRSCDNLESLRGWEGQAAINYNKVFNQMILQQKDSFTFHGRSRRPPKDNVNAMLSFAYTLLANDAAAALETVGLDAYVGFMHQDRPGRASLALDLMEELRGIYADRFVLSLINRKEVTADDFYKKENGAVLMSDDARKSFLKAWQTKKQEKISHPYLGEKISWGLVPYAQALLLARFLRGDLDEYPPFLWK
>NC_006582.1|WP_041824839.1|3741785_3742076_-|CRISPR-associated-endonuclease-Cas2
MLVLITYDVQTSSLGGSKRLRKVAKACQNYGQRVQNSVFECIVDSAQLTSLKLELSSLIDKEKDSLRIYRLGNNYKSKVEHIGAKPTVDIEDPLIF
>NC_006582.1|WP_011248428.1|3740577_3740991_-|hypothetical-protein
MTWHNQDPLNLSKEEWINLLQDEKVFNKIGLEMVFFVYKQPNYQSNATEIGEALGGVSQQQVTAWNRSIAKKIYQKLQKEPPFNSRGGKRYWNVLFDGAVERELDDKGNFIWKLRPSLVSALKRLGTSCNKTAKIES
>NC_006582.1|WP_011248427.1|3738258_3738762_-|hypothetical-protein
MKSPLKALTVSVILLLAGLVLGDDRMEAHELPLFHFEKTLIEPSEMRYNPTGEVDFPTVIRAADYFENPLGTYYMYYGPHDAPGGIALAYADSVTGPWTEYASNPVISRNWQPHYNVSHVASAHPIWNEEEGKLFLYFHGENSVTRLASSEDGIHFDYEQVVIDTSD
>NC_006582.1|WP_011248437.1|3752518_3754078_-|BCCT-family-transporter
MKSGPINKKRTMENKIVFPSILIIAIVSFLFAIYTEESTTLLNRIFDTIVDLFAWGYMWYALLMVVTGIWLAYSKYGQVVLGDPSEKPRYTLFEYASILVAMGVGATLMRTGMVQWSEVAVDPPFGLQAGSSEALLTGNAYSMFLWSFQTFAVFVMAAPAMAYILHVRKKPKMRISEACRVIFGDKFTDGLGGIVLDTLFLVSILAGAAVTLGLGTPIVTENLAELFNIEVTFLLTMIVTLIWVFVFTLSAYVGLDKGIKRLSTMNMYLAGVFALFIMIIGPGIFILDFFTDSVRVLVSRYLDFSLYTNSLHTEGGGSHIESHTVFWFAYNATWAMLHGVFAAVVSKGRTIKEMILTYLLAPTMLSWVATGILGGLGVERHTSGDVSVLNIVQEQEPVTAVPQILASIPIPEISIAVFIIIATIFLVTTLDSTTYTIATYMSTQDMSRRTPSRHLRIFVAVVITVLALTLMNIGGLAPLEVLSGLMGIPIIAIQILTIIAAKKMMDEDKAWINNVRKEK
>NC_006582.1|WP_152024052.1|3754481_3754802_-|hypothetical-protein
MEVDAPDGALVLYPTELEELREKEGKHFLFFITTDEDQTGYIVTSKPDNEGPGLLFPIQEEFDACSELFLAIPLPLSHSDSFVYKEASSYEEMTEAIEIAKNERKR
>NC_006582.1|WP_011248439.1|3755328_3755799_+|hypothetical-protein
MSNEHEVLLDNEKQNEPEIKVERREGEPTGAFKGATWAALIVGVGAYFIGLFNANMELNEKGYYFAVLIFGLYSSVSLQKAVRDKDEGIPVTSIYYGISWVALIVAILLMGIGLYNAGSIVLSEKGFYGMSFVLSLFAAITVQKNIRDTQRARERD
>NC_006582.1|WP_011248440.1|3756328_3757339_-|LacI-family-DNA-binding-transcriptional-regulator
MKVTIKEVARHAGVSIATVSKVINNRDYVSEKTREKVKRAIAELQYEVNANAQSLKAVRSRKVAVLVSDISNTYLMSIAKAVEEMIRSIGYHMILMSHNDAPDIEYELLQIVQQQQVDAMVLIPTGENSSTIKRMVTLGVHVIAVDRKVNDLQTDYIADDNFYGSYESVRYLQSLRHQRIAVLYGHRRNSIGEERYQGALAALKEGNTYDPTLFRGANFKEEEAYRLTTELLSLPEPPTAIYSANNTMTLGVLQAIKERGLEMPNDISVIAFGDETQWKLFRPKLTLMVQQAQQIGLEAAIMLKNRLTIEKPYPVQERIIKPVLQQNETCNVLRGH
>NC_006582.1|WP_011248441.1|3757536_3758412_+|ribokinase
MIAIVGSINIDLVVYTSNMPVPGETVLGDKFRTNPGGKGANQAVAAARLGAAVTMVGRVGNDPYGKLATENLRNEQVETGYIDVDNAAHTGVAMITVTNNDNSIVVAPGANFSWKREEAGLYRELLRQSKVLLLQLEVPLPFIEEIAKLGKEEQCTTILNPAPAQQLSPSMLDLVDFITPNETECQTIFKQPVEQAVRNYPNKLIVTEGKKGATYHDGNRLVRVNGFLAKAVDTTGAGDTFNGAFAAALASEHPLAEAVSFANAAASLSVEKAGAQSGMPTKKQVVHRLGT
>NC_006582.1|WP_011248442.1|3758431_3759913_-|tripartite-tricarboxylate-transporter-permease
MDTVMLVLQPGVLFFMLLGTFLGLFIGALPGLTATMGVAVLTPLTFWLAPQEGLAMLIAIYCTAIFASGIPAILVNTPGTPASVTTTFDGYPLTQQGKQGVALGINALYSGLGGLVSTAFLIFAAFPISKVALLFGPAEYFALAVFGLTIMVSVSSGSIIKGLISGGIGLFIVTIGLDPIRNIPRFTYDYPPLLEGLSFIPIMIGLFGLAEVFSQMLSKQTTKTGTTEKVGRILPNKAERKEVRKPFWMSSILSTFIGVIPGAGGDIASIISWNQAKNMAKGEKKAEYGKGSLGGLTASCTSNSAVIGGAFTTMMTLGLPGDAVTAILIGSLMMYGLDPGPALFTENIEMVHLIFALLIISNLLVIVVGLLGSNLFTRIIQIRQEFIHLAVVLFCIVGAYALNNSYFDVWVMVIAGFFGLLFKKLRIPLGPLILALILGPLAEANFRRAIMISGGSMDIFFTSPIAIALFVIAGLSVLIPMFRRNPKNNAPSA
>NC_006582.1|WP_011248443.1|3759926_3760361_-|tripartite-tricarboxylate-transporter-TctB-family-protein
MKTANLLLNGTITVACLIFFYQTFHFPMLFGIEDSGPALFPRIALAALLLFVIIDSAVIIRKRDGEFFFTKEERGNLWRLALLIGLLVFFVFFLGKLPFLILSLVTMFLIGLVFQLKWGPALLTAVVLTFFIQFVFIKGLNIIL
>NC_006582.1|WP_011248444.1|3760372_3761344_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MDRLTNLFISIVAALCLASCSNQSPEEADERYPEDQVSLIVPFATGGASDVVSRAVAMAMEEELGVPVVVVNKTGGVGAIGVYDVMMANADGYRIGYVPVELVMYDGLQIASISPYEFAYISRLMEIPAAITVSADAPYNTLDEFITYAKEHPGELQIGNSGTGSIWHIAAGALAQEAGVEFNYVPFEGAAPAVGSLLGGHIDAVSVSPSEVKTGLDSGDLKVLGVMGNERDPVVPDVPTMKEQGYDVVLGGWGGFVAPKDTPEEIIAALDAAIEKSMETETFQTLAESRGLTPAYLPGQAFEAFAVEQYEFFNELIPSIEME
>NC_006582.1|WP_011248445.1|3761410_3762316_-|dihydrodipicolinate-synthase-family-protein
MKRLYGITTAMVTPFTETGEVDVPAVRALTDFLIEKGVHGLFPLGTTGEMNKLSIEERKQVAEAVISQAAGRVHVFIQVGAQTMGSTLELARHALEAGADGIGVVTPFFLGADDRELEEYYVTVAKQLPDDFPVYLYNIPQASANDLKPEVAERIVRRTENVVGIKYSYPDFVRLQEYSFVNGGDFSVLTGTDRLLTAALALGCDGTVSGVSGVWPEPFVRAYEAFCMGDLETARTHQSVATAYCVALKGGSNMSYFKEALKMRGIDVGGMRRPQLDLTASQLSELKSALKKVESRNSDIN
>NC_006582.1|WP_011248446.1|3762929_3763886_-|class-II-fructose-bisphosphatase
MRDFLFSMAHVTEQAAVASFPWIGTGNKIEADRASTEAMRAALNRIPFRGRIAIGEGEMDEAPMLYIGEIVGNGSGPLFDLAVDPLDGTTPAAKGQGDCIAVLAGAPHGTLLHAPDMYMEKLATGAEAKGAVHLDAPIEANIQAVARAKNKAVKDVTVIVQDRTRHQKLVQRARDTGAKVKLFHEVDVTAALATALPDHDIDLFVGIGGAPEGVVAAVAIKCLGGDFQGRLLPDGHQQLARCQQMGLDNPNQLLNLHDLVASQQCFFIATGVTDGLLVDGVKKNSQGELATHTFMVDGVSNEIRVVQTIHRPEQVLMK

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Crispr_ID: NC_006582_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006582_8

3756033-3756121

TypeI

Consensus_repeat	Method
ATAACCCAATAAGTTCATATAAAAC	CRISPRCasFinder

1 spacers

cas3,cas5,cas8c,cas7,cas4,cas1

The CRISPR arrays of NC_006582_8

>merge|NC_006582|8|3756033-3756121|CRISPRCasFinder
ATAACCCAATAAGTTCATATAAAACGATCATTGAGCGCTCAAGTTCCGCAAGCATATGCGGATTAATACCCAATAAGTTCATATAAAAC

>NC_006582|8|8|3756033-3756121|CRISPRCasFinder
ATAACCCAATAAGTTCATATAAAAC	GATCATTGAGCGCTCAAGTTCCGCAAGCATATGCGGATT
AATACCCAATAAGTTCATATAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_006582.1\|WP_011248445.1\|3761410_3762316_-\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|188630
NC_006582.1\|WP_011248442.1\|3758431_3759913_-\|tripartite-tricarboxylate-transporter-permease	unknown	unknown	gnl\|CDD\|225870
NC_006582.1\|WP_011248432.1\|3743761_3744619_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|226175
NC_006582.1\|WP_011248447.1\|3763896_3764526_-\|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl\|CDD\|274099
NC_006582.1\|WP_011248430.1\|3742084_3743116_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NC_006582.1\|WP_011248449.1\|3765555_3766017_-\|ribose-5-phosphate-isomerase-B	unknown	unknown	gnl\|CDD\|376799
NC_006582.1\|WP_011248435.1\|3747647_3750062_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_006582.1\|WP_011248448.1\|3764539_3765550_-\|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl\|CDD\|376910
NC_006582.1\|WP_011248434.1\|3746500_3747211_-\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|273847
NC_006582.1\|WP_011248433.1\|3744615_3746499_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	gnl\|CDD\|187887
NC_006582.1\|WP_011248446.1\|3762929_3763886_-\|class-II-fructose-bisphosphatase	unknown	unknown	gnl\|CDD\|236536
NC_006582.1\|WP_011248441.1\|3757536_3758412_+\|ribokinase	unknown	unknown	gnl\|CDD\|238579
NC_006582.1\|WP_011248443.1\|3759926_3760361_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl\|CDD\|377815
NC_006582.1\|WP_041824141.1\|3743112_3743772_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|224385
NC_006582.1\|WP_011248439.1\|3755328_3755799_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227027
NC_006582.1\|WP_011248444.1\|3760372_3761344_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NC_006582.1\|WP_011248440.1\|3756328_3757339_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_006582.1\|WP_011248437.1\|3752518_3754078_-\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NC_006582.1\|WP_152024052.1\|3754481_3754802_-\|hypothetical-protein	unknown	unknown	unknown
NC_006582.1\|WP_011248436.1\|3750381_3751062_-\|amino-acid-racemase	unknown	unknown	gnl\|CDD\|224707

Protein	Function_ID	Function_description	E-value
NC_006582.1\|WP_011248445.1\|3761410_3762316_-\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	1.30927e-92
NC_006582.1\|WP_011248442.1\|3758431_3759913_-\|tripartite-tricarboxylate-transporter-permease	gnl\|CDD\|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	5.35888e-154
NC_006582.1\|WP_011248432.1\|3743761_3744619_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|226175	COG3649, COG3649, CRISPR system related protein [Defense mechanisms].	7.08843e-145
NC_006582.1\|WP_011248447.1\|3763896_3764526_-\|dihydroxyacetone-kinase-subunit-L	gnl\|CDD\|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	7.99921e-55
NC_006582.1\|WP_011248430.1\|3742084_3743116_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NC_006582.1\|WP_011248449.1\|3765555_3766017_-\|ribose-5-phosphate-isomerase-B	gnl\|CDD\|376799	pfam02502, LacAB_rpiB, Ribose/Galactose Isomerase. This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).	5.00483e-70
NC_006582.1\|WP_011248435.1\|3747647_3750062_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	2.77016e-125
NC_006582.1\|WP_011248448.1\|3764539_3765550_-\|dihydroxyacetone-kinase-subunit-DhaK	gnl\|CDD\|376910	pfam02733, Dak1, Dak1 domain. This is the kinase domain of the dihydroxyacetone kinase family EC:2.7.1.29.	1.68959e-161
NC_006582.1\|WP_011248434.1\|3746500_3747211_-\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|273847	TIGR01876, cas_Cas5d, CRISPR-associated protein Cas5, subtype I-C/DVULG. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum. This family belongs to a set of several Cas protein families, one each for a number of different CRISPR/Cas subtypes, that share a region of N-terminal sequence similarity modeled by TIGR02593. This family represents the Dvulg subtype of CRISPR/Cas locus.	3.75602e-116
NC_006582.1\|WP_011248433.1\|3744615_3746499_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	0
NC_006582.1\|WP_011248446.1\|3762929_3763886_-\|class-II-fructose-bisphosphatase	gnl\|CDD\|236536	PRK09479, glpX, fructose 1,6-bisphosphatase II; Reviewed.	1.23321e-166
NC_006582.1\|WP_011248436.1\|3750381_3751062_-\|amino-acid-racemase	gnl\|CDD\|224707	COG1794, RacX, Aspartate racemase [Cell envelope biogenesis, outer membrane].	9.40651e-62
NC_006582.1\|WP_011248443.1\|3759926_3760361_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	0.000805338
NC_006582.1\|WP_041824141.1\|3743112_3743772_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|224385	COG1468, COG1468, CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms].	2.73579e-37
NC_006582.1\|WP_011248439.1\|3755328_3755799_+\|hypothetical-protein	gnl\|CDD\|227027	COG4682, COG4682, Predicted membrane protein [Function unknown].	3.14633e-46
NC_006582.1\|WP_011248444.1\|3760372_3761344_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.36444e-107
NC_006582.1\|WP_011248440.1\|3756328_3757339_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.24147e-100
NC_006582.1\|WP_011248437.1\|3752518_3754078_-\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	3.30609e-146
NC_006582.1\|WP_011248441.1\|3757536_3758412_+\|ribokinase	gnl\|CDD\|238579	cd01174, ribokinase, Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.	7.66425e-119

>NC_006582.1|WP_011248439.1|3755328_3755799_+|hypothetical-protein
MSNEHEVLLDNEKQNEPEIKVERREGEPTGAFKGATWAALIVGVGAYFIGLFNANMELNEKGYYFAVLIFGLYSSVSLQKAVRDKDEGIPVTSIYYGISWVALIVAILLMGIGLYNAGSIVLSEKGFYGMSFVLSLFAAITVQKNIRDTQRARERD
>NC_006582.1|WP_152024052.1|3754481_3754802_-|hypothetical-protein
MEVDAPDGALVLYPTELEELREKEGKHFLFFITTDEDQTGYIVTSKPDNEGPGLLFPIQEEFDACSELFLAIPLPLSHSDSFVYKEASSYEEMTEAIEIAKNERKR
>NC_006582.1|WP_011248437.1|3752518_3754078_-|BCCT-family-transporter
MKSGPINKKRTMENKIVFPSILIIAIVSFLFAIYTEESTTLLNRIFDTIVDLFAWGYMWYALLMVVTGIWLAYSKYGQVVLGDPSEKPRYTLFEYASILVAMGVGATLMRTGMVQWSEVAVDPPFGLQAGSSEALLTGNAYSMFLWSFQTFAVFVMAAPAMAYILHVRKKPKMRISEACRVIFGDKFTDGLGGIVLDTLFLVSILAGAAVTLGLGTPIVTENLAELFNIEVTFLLTMIVTLIWVFVFTLSAYVGLDKGIKRLSTMNMYLAGVFALFIMIIGPGIFILDFFTDSVRVLVSRYLDFSLYTNSLHTEGGGSHIESHTVFWFAYNATWAMLHGVFAAVVSKGRTIKEMILTYLLAPTMLSWVATGILGGLGVERHTSGDVSVLNIVQEQEPVTAVPQILASIPIPEISIAVFIIIATIFLVTTLDSTTYTIATYMSTQDMSRRTPSRHLRIFVAVVITVLALTLMNIGGLAPLEVLSGLMGIPIIAIQILTIIAAKKMMDEDKAWINNVRKEK
>NC_006582.1|WP_011248436.1|3750381_3751062_-|amino-acid-racemase
MIGILAGMGPKSTGPFVDKTVDQCQKIYGAVNDIDFPHMMIYSCPTPFYIDKPLNHKDMEMAIINGAKRLEKTGVDFIAIPCNTAHVYFDQVKNSLSIPLLNMVEETIKRVPEHSKKVALLATIPTVQSGIFQEALAKEGYEFLHQDDWQTCINQIIEKIKQGQISESLELWDELYLQLADTIDTAIIACTDLNVVTDKSSGDISLVDSSTCLAEAIVHKYLSLKN
>NC_006582.1|WP_011248435.1|3747647_3750062_-|CRISPR-associated-helicase/endonuclease-Cas3
MYIAHVRETDKAKQTLKDHLLGASRIAEAHGAKLGLKHVAGLAGVLHDLGKFSDEFQDYLDKAVFHPELAEKKRGQVDHSTAGGKLLFGMLHNKENTFHEKLLAEIVGNAIISHHSNLQDYISPTIESNFLKRVLEKDLAEYGLAVERFFQEVVPKAEFTEYVTKAVEEIKQFTDNSPTQSFFLTKYIFSCLIDADRTDTRMFEEQAQEEERIQHRPLFEHYYQKLMNHLTSLKESSEAKQPINVLRSAMSDQCESFAKRPSGIYTLSIPTGGGKTLASLRYALKHAQEYEKQRIIYVVPFTTIIEQNAQEVRGILEDNENILEHHSNVIEEEYSESEFGDEQEDGMITKKERLKLARDNWDSPIIFTTLVQFLNVFYAKGNRNTRRLHNLSHSVLIFDEVQKVPTKCVSLFNEALNFLKKSAHCSILLCTATQPSLENVKHGLLKERDGEIVPNLTEVSEAFKRVEIINKTAKPMTNEELAEWIRAEATSWGSTLVILNTKSAVKNLYEKLKGGPLPVFHLSTSMCAAHRKEQLNEIRTLLQEGTPFICVTTQLIEAGIDVSFKCVIRSLAGLDSIAQAAGRCNRHGEDRLRYVYVIDHAEEKLSKLKEIEAGKWIAGNIFANFKKKAEKYEGNLLSQAAMREYFLYYYNRMDAELNYYVSKVDKEMTKLLMFHAKENSYVTHFQKKNGTAFPLLLNGSYKTAADHFRVIDQHTTSVIVPYGDGRDIIAQLNSDEWVDDLGKVLREAQQYTVNLYSQEIDQLKKENALVMHLDGMVYELKESWYHDKYGVDLKGEGGMEFTSW
>NC_006582.1|WP_011248434.1|3746500_3747211_-|type-I-C-CRISPR-associated-protein-Cas5
MKNEIQFEVFGDYALFTDPLTKIGGEKLSYSVPTYQALKGIVESIYWKPTIIFTIDKLRVMKPIQMESKGVRPIDYGGGNTLAHYTYLKDVHYQVKAHFDFNFNRPDLAFDRNEGKHYSILQRSLKAGGRRDIFLGTRECQGYVAPCEFGSGSGYYDGQGEYRLGTMVHGFNYPDETGQNQLDVRLWPAVMNDGYIKFPKPEDCTMIRPIKEMEPKEFKRDDIQSVEQLSYEVGGE
>NC_006582.1|WP_011248433.1|3744615_3746499_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSWLLQLHQTYDDNLDQVGKTVKKGEDREYTLLPISHTTQNAHIEVTIDEDGDFLRAKALTKASTVIPCTEEAASRSGSKIAPYPLHDKLSYVAGDFVKYGGEIKNQDDVPFDTYIKNLAEWANSPYGTEKVKCIYTYLKKGRLIEDLVSEEVLVLDKNQQLLEKWDKSYEEQLGGKPAIFSSGATDQYSAFVRFNVFHPESIDDVWKDKQMFDSFIAFYNEKLGEEDICFVKGERLPSTERHANKIRHAADKAKLISANDNTGFTFRGRFKTSKEAVGISYEVSQKAHNALKWLIHRQGKTIDERVFLVWSNDNSPVPNPDDDAVDMMRHSNRELERDPETGQLFAKEVTKAIGGYRSDLKYQPEVNILVLDSATTGRMAVLYYRNLNKELYLDRLEEWHQFCAWEHRYKRDEKEFISFFGAPATKDIAFAAYGPRASDKVVKGLMERMLPCIVDKRPIPKDIVKSAFHRASNPVAMERWEWEKTLSITCALIRKMFIEKKEEWGVALDQHSKDRSYLFGRLLAVADVLERGALGKDETRATNAIRYMNSFAKNPSRTWKTIQESLQPYQAKLGTKSTYLSKLIDEISDQFDIDDFNNTPLTEKYLLGFYSQRRELYKKKEEEPNQ
>NC_006582.1|WP_011248432.1|3743761_3744619_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSTLDHKIDFAVILSVSKANPNGDPLNGNRPRQNYDGHGEISDVAIKRKIRNRLQDMGEPVFVQSDDRKVDSHKSLRERADSNPELAKMLKAKNASSDDFAQIACEEWIDVRSFGQVFAFKGSNLSVGVRGPVSIHTATSIDPIDIVSTQITKSVNSVTGDKRSSDTMGMKHRVDFGVYVFKGSINTQLAEKTGFTNEDAEKIKQALVTLFENDSSSARPDGSMEVHKVYWWEHSSKLGQYSSAKVHRSLKVEAKTDSPKAFDEENYSVELSDLEGLSVEVLDGQ
>NC_006582.1|WP_041824141.1|3743112_3743772_-|CRISPR-associated-protein-Cas4
MVSKEEDRYLMLSGLQHFQFCKRQWALIHIEQQWEENVRTIEGQHLHKKADQPFIKEKRGSKLTVRAMPIQSKQLQISGICDVVEFVEDPDGVELSGVSGTYQAFPVEYKRGKPKKGDEDIVQLVAQAICLEEMLVCRIDKGYLFYNEIKHRVEVAITDSLREKVVEMAKEMHHYYDNRYTPKVKTGPFCKNCSLQHICLPKLMNKRSVKSYIEGRLSE
>NC_006582.1|WP_011248430.1|3742084_3743116_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MKKLLNTLYVTQPDTYLSLDGDNVVLLKEQEKLGRLPLHNLESIVSFGYTGASPALMGYCADRNISITFLTKNGRFLARVVGESRGNVVLRKTQYRISESEKESTNIARNFIIGKIYNNKWMLERMTREHPLRVDVEQFKSISQLLSTILQEVRSCDNLESLRGWEGQAAINYNKVFNQMILQQKDSFTFHGRSRRPPKDNVNAMLSFAYTLLANDAAAALETVGLDAYVGFMHQDRPGRASLALDLMEELRGIYADRFVLSLINRKEVTADDFYKKENGAVLMSDDARKSFLKAWQTKKQEKISHPYLGEKISWGLVPYAQALLLARFLRGDLDEYPPFLWK
>NC_006582.1|WP_011248440.1|3756328_3757339_-|LacI-family-DNA-binding-transcriptional-regulator
MKVTIKEVARHAGVSIATVSKVINNRDYVSEKTREKVKRAIAELQYEVNANAQSLKAVRSRKVAVLVSDISNTYLMSIAKAVEEMIRSIGYHMILMSHNDAPDIEYELLQIVQQQQVDAMVLIPTGENSSTIKRMVTLGVHVIAVDRKVNDLQTDYIADDNFYGSYESVRYLQSLRHQRIAVLYGHRRNSIGEERYQGALAALKEGNTYDPTLFRGANFKEEEAYRLTTELLSLPEPPTAIYSANNTMTLGVLQAIKERGLEMPNDISVIAFGDETQWKLFRPKLTLMVQQAQQIGLEAAIMLKNRLTIEKPYPVQERIIKPVLQQNETCNVLRGH
>NC_006582.1|WP_011248441.1|3757536_3758412_+|ribokinase
MIAIVGSINIDLVVYTSNMPVPGETVLGDKFRTNPGGKGANQAVAAARLGAAVTMVGRVGNDPYGKLATENLRNEQVETGYIDVDNAAHTGVAMITVTNNDNSIVVAPGANFSWKREEAGLYRELLRQSKVLLLQLEVPLPFIEEIAKLGKEEQCTTILNPAPAQQLSPSMLDLVDFITPNETECQTIFKQPVEQAVRNYPNKLIVTEGKKGATYHDGNRLVRVNGFLAKAVDTTGAGDTFNGAFAAALASEHPLAEAVSFANAAASLSVEKAGAQSGMPTKKQVVHRLGT
>NC_006582.1|WP_011248442.1|3758431_3759913_-|tripartite-tricarboxylate-transporter-permease
MDTVMLVLQPGVLFFMLLGTFLGLFIGALPGLTATMGVAVLTPLTFWLAPQEGLAMLIAIYCTAIFASGIPAILVNTPGTPASVTTTFDGYPLTQQGKQGVALGINALYSGLGGLVSTAFLIFAAFPISKVALLFGPAEYFALAVFGLTIMVSVSSGSIIKGLISGGIGLFIVTIGLDPIRNIPRFTYDYPPLLEGLSFIPIMIGLFGLAEVFSQMLSKQTTKTGTTEKVGRILPNKAERKEVRKPFWMSSILSTFIGVIPGAGGDIASIISWNQAKNMAKGEKKAEYGKGSLGGLTASCTSNSAVIGGAFTTMMTLGLPGDAVTAILIGSLMMYGLDPGPALFTENIEMVHLIFALLIISNLLVIVVGLLGSNLFTRIIQIRQEFIHLAVVLFCIVGAYALNNSYFDVWVMVIAGFFGLLFKKLRIPLGPLILALILGPLAEANFRRAIMISGGSMDIFFTSPIAIALFVIAGLSVLIPMFRRNPKNNAPSA
>NC_006582.1|WP_011248443.1|3759926_3760361_-|tripartite-tricarboxylate-transporter-TctB-family-protein
MKTANLLLNGTITVACLIFFYQTFHFPMLFGIEDSGPALFPRIALAALLLFVIIDSAVIIRKRDGEFFFTKEERGNLWRLALLIGLLVFFVFFLGKLPFLILSLVTMFLIGLVFQLKWGPALLTAVVLTFFIQFVFIKGLNIIL
>NC_006582.1|WP_011248444.1|3760372_3761344_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MDRLTNLFISIVAALCLASCSNQSPEEADERYPEDQVSLIVPFATGGASDVVSRAVAMAMEEELGVPVVVVNKTGGVGAIGVYDVMMANADGYRIGYVPVELVMYDGLQIASISPYEFAYISRLMEIPAAITVSADAPYNTLDEFITYAKEHPGELQIGNSGTGSIWHIAAGALAQEAGVEFNYVPFEGAAPAVGSLLGGHIDAVSVSPSEVKTGLDSGDLKVLGVMGNERDPVVPDVPTMKEQGYDVVLGGWGGFVAPKDTPEEIIAALDAAIEKSMETETFQTLAESRGLTPAYLPGQAFEAFAVEQYEFFNELIPSIEME
>NC_006582.1|WP_011248445.1|3761410_3762316_-|dihydrodipicolinate-synthase-family-protein
MKRLYGITTAMVTPFTETGEVDVPAVRALTDFLIEKGVHGLFPLGTTGEMNKLSIEERKQVAEAVISQAAGRVHVFIQVGAQTMGSTLELARHALEAGADGIGVVTPFFLGADDRELEEYYVTVAKQLPDDFPVYLYNIPQASANDLKPEVAERIVRRTENVVGIKYSYPDFVRLQEYSFVNGGDFSVLTGTDRLLTAALALGCDGTVSGVSGVWPEPFVRAYEAFCMGDLETARTHQSVATAYCVALKGGSNMSYFKEALKMRGIDVGGMRRPQLDLTASQLSELKSALKKVESRNSDIN
>NC_006582.1|WP_011248446.1|3762929_3763886_-|class-II-fructose-bisphosphatase
MRDFLFSMAHVTEQAAVASFPWIGTGNKIEADRASTEAMRAALNRIPFRGRIAIGEGEMDEAPMLYIGEIVGNGSGPLFDLAVDPLDGTTPAAKGQGDCIAVLAGAPHGTLLHAPDMYMEKLATGAEAKGAVHLDAPIEANIQAVARAKNKAVKDVTVIVQDRTRHQKLVQRARDTGAKVKLFHEVDVTAALATALPDHDIDLFVGIGGAPEGVVAAVAIKCLGGDFQGRLLPDGHQQLARCQQMGLDNPNQLLNLHDLVASQQCFFIATGVTDGLLVDGVKKNSQGELATHTFMVDGVSNEIRVVQTIHRPEQVLMK
>NC_006582.1|WP_011248447.1|3763896_3764526_-|dihydroxyacetone-kinase-subunit-L
MIQATDLKKALYSMRDKMAEERDYLCELDRHLGDGDHGVTMDIGWKAVAQALDDLDAETDISVICKQVAMAFLNAVGSSVGPLYATGFLQAGKPFKGKNALTSEDVATFWIAFAEGIEARGGAKIGDKTMVDTLAPMAAYLRERGGGFDGEGALAAAEKGMESTKRLQANVGRSSRLGERSIGTIDPGAASAFLLFKAFCDSVQPREKV
>NC_006582.1|WP_011248448.1|3764539_3765550_-|dihydroxyacetone-kinase-subunit-DhaK
MKKLVNNPDVVVDEMIDGYLKAFPKLVEKVEGSGRALVAKQSLHGNGKVGIVIGGGSGHEPAFMGYIGRGMADGVAVGNIFASPPPQPIVEATEAVNQGNGVVYIYGNYAGDIMNFGMASDLADMEHDIKVESIIVRDDVASAPKREKEKRRGIAGEFFVTKVAGAASARGDDLSEVVRLTNKANESVRSMGVGLTPCALPQTGKPSFVLGENEMEIGLGHHGEPGVEKGPLQQADDVCDRLIDDILNDGDLKAGDDVAVLVNGLGSTTQMELFIMFRRVEQRLSEKQINIHRSYVGNYSTSMEMGGCSVTLMKVDEELKALIDAPAECPLYAQYE
>NC_006582.1|WP_011248449.1|3765555_3766017_-|ribose-5-phosphate-isomerase-B
MKIAIGSDHNAFELKEELKTYMIDEGYDVVDYGCHSCEAVDYPDVSFRVGNDIMKGEIDRGILICGTGIGVAIAAGKVPGIRAALCHDTYSAERAQLSNNAQILTMGAKVIGPEAAKKVLNAYLGASFAGGPSARKIQQIAEQEQAYLEQESR

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Crispr_ID: NC_006582_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006582_9

3807009-3807170

Orphan

Consensus_repeat	Method
ATTTCAATCCACGTACCCACAAAGAGTGCGAC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_006582_9

>merge|NC_006582|9|3807009-3807170|CRISPRCasFinder
AGTTTATGCGACGCACTCACATAGAGTGCGACCACTTGTAGACCGGACAGAAAAAGCAAAGAAAGATTTCAATCCACGTACCCACAAAGAGTGCGACATTAGTCAGCTGGGAGGACGACTGAAAGGAGGTATTTCAATCCACGCACCCACAAAGAGTGCGAC

>NC_006582|9|9|3807009-3807170|CRISPRCasFinder
AGTTTATGCGACGCACTCACATAGAGTGCGAC	CACTTGTAGACCGGACAGAAAAAGCAAAGAAAG
ATTTCAATCCACGTACCCACAAAGAGTGCGAC	ATTAGTCAGCTGGGAGGACGACTGAAAGGAGGT
ATTTCAATCCACGCACCCACAAAGAGTGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_006582.1\|WP_011248497.1\|3815558_3816482_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_006582.1\|WP_011248488.1\|3804996_3806019_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270264
NC_006582.1\|WP_041824853.1\|3817481_3819044_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173863
NC_006582.1\|WP_011248491.1\|3808223_3809414_-\|M20-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349883
NC_006582.1\|WP_011248483.1\|3798346_3799444_+\|RapH-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|376220
NC_006582.1\|WP_011248498.1\|3816493_3817411_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_006582.1\|WP_011248484.1\|3799561_3800320_-\|response-regulator	unknown	unknown	gnl\|CDD\|227095
NC_006582.1\|WP_011248481.1\|3796263_3797142_+\|ribokinase	unknown	unknown	gnl\|CDD\|238579
NC_006582.1\|WP_011248485.1\|3800324_3801995_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NC_006582.1\|WP_011248480.1\|3795019_3796138_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_006582.1\|WP_050748999.1\|3797248_3797980_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|224982
NC_006582.1\|WP_011248495.1\|3813491_3814526_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|185037
NC_006582.1\|WP_011248496.1\|3814522_3815515_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NC_006582.1\|WP_011248486.1\|3802180_3803836_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
NC_006582.1\|WP_011248493.1\|3810729_3812172_-\|DASS-family-sodium-coupled-anion-symporter	unknown	unknown	gnl\|CDD\|273267
NC_006582.1\|WP_142299545.1\|3812229_3813444_-\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349891
NC_006582.1\|WP_011248490.1\|3807509_3808019_+\|hypothetical-protein	unknown	unknown	unknown
NC_006582.1\|WP_011248489.1\|3806386_3806854_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NC_006582.1\|WP_011248492.1\|3809468_3810662_-\|M20-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349883
NC_006582.1\|WP_011248487.1\|3803837_3804932_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361

Protein	Function_ID	Function_description	E-value
NC_006582.1\|WP_011248498.1\|3816493_3817411_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	8.41585e-123
NC_006582.1\|WP_011248488.1\|3804996_3806019_-\|extracellular-solute-binding-protein	gnl\|CDD\|270264	cd13546, PBP2_BitB, Substrate binding domain of a putative iron transporter BitB, a member of the type 2 periplasmic binding fold superfamily. The substrate domain of this group shows a high homology to the periplasmic component of ferric iron transporter (Fbp), but its biochemical characterization has not been performed. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.17057e-97
NC_006582.1\|WP_041824853.1\|3817481_3819044_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173863	cd08498, PBP2_NikA_DppA_OppA_like_2, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NC_006582.1\|WP_011248491.1\|3808223_3809414_-\|M20-family-metallopeptidase	gnl\|CDD\|349883	cd03887, M20_Acy1L2, M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family. Peptidase M20 family, Aminoacylase 1-like protein 2 (ACY1L2; amidohydrolase) subfamily. This group contains many uncharacterized proteins predicted as amidohydrolases, including gene products of abgA and abgB that catalyze the cleavage of p-aminobenzoyl-glutamate, a folate catabolite in Escherichia coli, to p-aminobenzoate and glutamate. p-Aminobenzoyl-glutamate utilization is catalyzed by the abg region gene product, AbgT. Aminoacylase 1 (ACY1) proteins are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	1.29307e-150
NC_006582.1\|WP_011248483.1\|3798346_3799444_+\|RapH-N-terminal-domain-containing-protein	gnl\|CDD\|376220	pfam18801, RapH_N, response regulator aspartate phosphatase H, N terminal. Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.	3.71752e-21
NC_006582.1\|WP_011248484.1\|3799561_3800320_-\|response-regulator	gnl\|CDD\|227095	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms].	3.80928e-56
NC_006582.1\|WP_011248497.1\|3815558_3816482_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.00257e-105
NC_006582.1\|WP_011248485.1\|3800324_3801995_-\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	4.49146e-46
NC_006582.1\|WP_011248480.1\|3795019_3796138_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.99762e-47
NC_006582.1\|WP_050748999.1\|3797248_3797980_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl\|CDD\|224982	COG2071, COG2071, Predicted glutamine amidotransferases [General function prediction only].	1.76626e-77
NC_006582.1\|WP_011248495.1\|3813491_3814526_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|185037	PRK15079, PRK15079, oligopeptide ABC transporter ATP-binding protein OppF; Provisional.	2.10518e-150
NC_006582.1\|WP_011248496.1\|3814522_3815515_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	0
NC_006582.1\|WP_011248486.1\|3802180_3803836_-\|iron-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	1.22021e-108
NC_006582.1\|WP_011248493.1\|3810729_3812172_-\|DASS-family-sodium-coupled-anion-symporter	gnl\|CDD\|273267	TIGR00785, Uncharacterized_transporter_HI_0020, anion transporter. The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds].	5.07676e-45
NC_006582.1\|WP_142299545.1\|3812229_3813444_-\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|349891	cd03896, M20_PAAh_like, M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins. Peptidase M20 family, Poly(aspartic acid) hydrolase (PAA hydrolase)-like subfamily. PAA hydrolase enzymes are involved in alpha,beta-poly(D,L-aspartic acid) (tPAA) biodegradation. PAA is being extensively studied as a replacement for commercial polycarboxylate components since it can be degraded by enzymes from isolated tPAA degrading bacteria. Thus far, two types of PAA degrading bacteria (Sphingomonas sp. KT-1 and Pedobacter sp. KP-2) have been investigated in detail; the former can completely degrade tPAA of low-molecular weights below 5000, while the latter can degrade high molecular weight tPAA to release oligo(aspartic acid) (OAA) as a product, suggesting two kinds of PAA degrading enzymes. It has been shown that PAA hydrolase-1 from Sphingomonas sp. KT-1 hydrolyzes beta,beta-aspartic acid units in tPAA to produce OAA, and it is suggested that PAA hydrolase-2 hydrolyzes OAA to aspartic acid. Also included in this family is Bradyrhizobium 5-nitroanthranilic acid (5NAA)-aminohydrolase (5NAA-A), a biodegradation enzyme that converts 5NAA to 5-nitrosalicylic acid; 5NAA is a metabolite secreted by Streptomyces scabies, the bacterium responsible for potato scab, and metabolized by Bradyrhizobium species strain JS329.	3.57695e-94
NC_006582.1\|WP_011248481.1\|3796263_3797142_+\|ribokinase	gnl\|CDD\|238579	cd01174, ribokinase, Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.	7.64663e-118
NC_006582.1\|WP_011248489.1\|3806386_3806854_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.0031562
NC_006582.1\|WP_011248492.1\|3809468_3810662_-\|M20-family-metallopeptidase	gnl\|CDD\|349883	cd03887, M20_Acy1L2, M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family. Peptidase M20 family, Aminoacylase 1-like protein 2 (ACY1L2; amidohydrolase) subfamily. This group contains many uncharacterized proteins predicted as amidohydrolases, including gene products of abgA and abgB that catalyze the cleavage of p-aminobenzoyl-glutamate, a folate catabolite in Escherichia coli, to p-aminobenzoate and glutamate. p-Aminobenzoyl-glutamate utilization is catalyzed by the abg region gene product, AbgT. Aminoacylase 1 (ACY1) proteins are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	8.31633e-160
NC_006582.1\|WP_011248487.1\|3803837_3804932_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	2.13534e-150

>NC_006582.1|WP_011248489.1|3806386_3806854_-|hypothetical-protein
MEEKEMLELLLQKVTDLEFGLKEQREHNAAFAKDLKEQKEHNAAVAKDLKEQKAYNAAFAKDLKEQKTQVAGITKELKEQKEHYLAMAHDIKELKEDQIMVKQAVLETNQNVKNIEASLESLSDQVSQLSEDQKSVREILGDHEVAIRTLRRKPV
>NC_006582.1|WP_011248488.1|3804996_3806019_-|extracellular-solute-binding-protein
MKALKKFGVVVGLAVVATGCGGNGSSSDDTLVVYTTRSESLNEAVIPQFEKETGIRVQMISAGTGEAITRVESERNNPQGDVLWAADITMLYDKTDLFEEYVSPEDEYMMEGFKNTTGYFSPAFSDPTVFIVNTDLAGDMEIESFQDLLNPELKGRIAFGDPVNSSSAFQSLIAMLYAAGDGDPMSDQAWEFVKAFVANLDGKVQGSSGQVHKGVADGEYVVGLTWEDPVVHYKQSGAAVEVVFPTEGVVYPGQSIQIIKGTKNLENAKKFVDYVLSEEVQSRTGQELTVRPLREGVEVADYMTPQEEIKLFDQYDEMFIIENMDDITARYVEVLEGSMD
>NC_006582.1|WP_011248487.1|3803837_3804932_-|ABC-transporter-ATP-binding-protein
MGVAIDIDNVVKMYDEHTVIDGLSLTIQPGELFTLLGPSGCGKTTLLRMIIGFNSVDGGAIKVDGQRINDVPVSKRKMGMVFQNYAIFPHMTVAENIAFGLKTLKDSKAQMQSKIDHIMKVVHIQDHHSKKPDKLSGGQQQRVALARALVINPNVLLMDEPLSNLDAKLRIEMRNAIKEIQQEVGITTVYVTHDQEEALAISDRIAVMNKGVIQQIGKPEQIYLRPSNLFVAQFIGTSNVIKAKVEKQGTDTFIVFNGEYKEKLDNVVETVENGQEVLVSVRPQEFTITQEASAIAGVVESTMFLGINTHYLVTLTTGERVEVVQHIEDKAIIPEGTNIYVKVKPHLINLFDVANEQTLMKAGE
>NC_006582.1|WP_011248486.1|3802180_3803836_-|iron-ABC-transporter-permease
MRPKAFNGWNWITLSIVLFFALFILFPVVLVLNKSIYNGEAGRFTLEHFSLFFERKFYWVTLWNSIKVTVVATVLAVLIGLPLAYMLRRVKIFGSGIVQILIIVSYISPPFIGAYAWIQLLGRSGVITKWINDTFQLQFDGIYGFAGIVLVLTLQSFPLIFIYISGALKNLDNSLIEAAESLGYSGVQRVIKIVVPLIAPTILASSLLVFMRVIADFGTPMLIGEGYRTIPVLIYTQFMSEVGGDAGFAAALASIFIIVTIALFLVQRVIARQYSYSMSALRPMETKKSTGLKNLLSHVAVYGVTLLAILPQLVVVYTSFLETIGGQVYTGKFSLQNYENILFNRDLSMILNTYQLGLIAIVVIVILGILIAYLTVRKRNKVTSLLDTVSMLPFVIPGSVLAMALIFAFGEAPLYLTGTSLIMVLAFVIRRMPYTVRSSTAIVSQISPSMEEAAISLGASERRTFFRVVVPMMMPGVLAGAIMSWMTILGELSASIILYSTNTQTLAVSIYTEVIRGNFGNASAYSAILTVTSILSLFLFFKLTGKKEMNV
>NC_006582.1|WP_011248485.1|3800324_3801995_-|sensor-histidine-kinase
MERRRMKDDIQRSFLTNAIVIISAILCVYLLSLLFLFNVSIVRPSQATNERVAKEVEAEFAHYKEGMARLVADEQIRAFLRGEGKSGEVNQLLYDFRNAQTFQSDFVLLDSEEEIVATSLYEGQKEQLQQSPVLREQMQQAEEHPFTGEYVNKRAFNAGQGGAYVFAAAVEEGEERTGYLLFLLEHTLPSASEQIVFVTDSFYNAVFYSHTFGIGALGKLTIPTDGFLVQYDGNPFYVTKTEVAGQPIQVITLTSVKTYQLLLLYGLLAMVVSSFVMLAVVWLVTPKILKKTLEPFDALVARISSKNNHLHFQQTDHVFAEVQTIYEEYTNKVHEIQALVDKNEEILEKKRLSEIKHLEAKFNPHFLYNVLEMIKYETLANPESAAEMIVKTAKLMRYNAHFGDTTVLLEEDIAYLRDYFALQKMRYGKRLDYTIAIEPELGRARVPKLLLQPLIENAIKHNIDGIRCLNVDVSAYWENGVLTFVVEDNGLGITPGKMAKIKAIMAGERKEAAHTGLKNTHQMIQLLYGQRYGIDIASAPEKGEGTTVRMHIPYEG
>NC_006582.1|WP_011248484.1|3799561_3800320_-|response-regulator
MLKVAIVEDEPILLKGLLYRVDWLSNDCTVVGAAEDGAEGLNLIKQTKPDIIITDIRMPFKDGLAMLKEAKADHSFEAIILSGFGEFDYAKQAITIGVHDYLLKPVDMHELEATLQKLVQKLQAQKSNDHLTKQTKVYSHLLDLGRGSHSTYVAEIMDFIKKHYHEKVTLKAASNEIGLSTVSLNDKLKEKTGYSFNELVTRYRLTKAISLLQDEKLLIYEVAEKTGFSDYKYFSQVFKKYTGMSPKQFCGK
>NC_006582.1|WP_011248483.1|3798346_3799444_+|RapH-N-terminal-domain-containing-protein
MTVAVSPEKAGATIAEWYSCIIARSVEQASQLKEKVDAMFKQIEKNERLLAYYALVNFRYRLMCKQASQRGADDEMLKRAGMVAEESVDHLLKYLYYFSCGQNEFVNERYRSAITLFRKAERLLEYVENKEEEAEFHYYMGLSLYRISQYPFAGSYIEEALVEFNRLGNKERSIHCQTILGGIYSETKQYDKAVLILNEALAAAHPYPFSKMAVLRALGLNALRYHHYEQARQWFEKTLSYHEFQHTLIGVKNTYNLANTLYRLNLSQHAAPYLKKAAIGAEFYRNKEYKARCLATRGLYAEGNYALIDKAIEQLDKEGFDFEVDELAEEAATYFEQAGHTTLALKYLKIAYHAKQNLFKLGAGQ
>NC_006582.1|WP_050748999.1|3797248_3797980_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MLAMAKPVIGITSTIALHNQIPSVDLAEKVVKAVMNAGGVPIVLPVGNVELASDWIKACDGLILSSGEDVDPYLYKAEPSPKLQKTFKQRDEVEMELVKQALQQKKPIFAICRGIGVLNVALGGSLMQDIETGLPNACKHYQEAGRTDVTHRIQIVKDSLLHQVIGSEEIRVNSLHHQAIGRLAPPLKQVASAADGVIEAVEGKAGMPYVLGVQWHPEELAANDAAMARLFTVLIERASEKSI
>NC_006582.1|WP_011248481.1|3796263_3797142_+|ribokinase
MITVVGSINIDLVVHTGTMPVLGETVLGGEFQTNPGGKGANQAVAAARLGADVTMIGKVGNDPYGKLVTDNLQNEQINTDYIEVEKDGHTGVAMITVTNNDNAIVVAPGANFSWKPEEAAQYRDVFKQTNVLVLQLEVPLPFIEEIAKIGKEERCIVILNPAPAQPLPSSLLDLVDYITPNETECQTIFKQSVEQAVQRYPNKLLVTEGKKGAAYHDGQQLVQVNGFPANVVDTTGAGDTFNGALAAALASGQQLAEAVTFANAAASLSVEQAGAQAGMPSKQQVLARLGSS
>NC_006582.1|WP_011248480.1|3795019_3796138_+|HAMP-domain-containing-histidine-kinase
MGIKTRFTLHFALGLTLWLLGTGLSLVILFEVLLPLFDVVVGENTEGLLVGSIFALSTLVCIGLFGWYFGGPIAFIMRWIHQLSQGNYKQPPGLRKIYTRKETLRMRYLLYKEVLHSLQLLAEQLQANEVERKKIEQAKQEWIAGISHDLKTPLTYITGYSTLLLTNQYEWSTEEARSFTQEIYDKGKHMEELIQDLNLVLKLNDGVHLFPINTTSQDLVEFTKRVVADISNSPQAVDYRLHFKTNKPRIDVDFDDKFMQRILQNILMNSIIHNPEPVDIYIELFDYNEQARIHITDNGIGMPTHMMENLFQQYYRGATTDSASEGTGLGMAIVYNLVRAHHGTISVESEPSKGTSFDIHFPKKGRPQDNMS
>NC_006582.1|WP_011248490.1|3807509_3808019_+|hypothetical-protein
MTAYAQSPEEIRESFLLVLNLMLFLYICLFILWLIAHLIVAAALSRMAKNAHIRHPWLSWIPIAQFWIVGELISGKLRGNGGIKVLLIGCVTIVFRFLPFHHLYIHLLVKIPEPIYRFVSLTLWILLIYIVYRLYEAYAKKAWIHTVLSIIPFYAPIALFVLRNRERRY
>NC_006582.1|WP_011248491.1|3808223_3809414_-|M20-family-metallopeptidase
MATTILAEKQEILTALDQRDEELRELALMIHANPELSFKEYKAAEWLSAYLEKEGFQVERGTAGLETAFTAIWEGNPGGPVIGILAEYDALPNLGHACGHNLIGTAAVGAAVALKDAYPELQGTIKVIGTPAEEGGGGKIYMCDHGTFNDLDAAMMVHPKNKTMVLRGGLACMTATFSFYGKESHAASAPEKGISALDALIQSYNAINSLRQFFTDDVRIHGIITKGGDAANIVPGHCEAQFIIRAATTNRLHEIKEKVYEAVRHSSQSVGAKYKIEEGLIYAERNNNHALAELFKQNWEAMGIEVEDPPKQGGIGSSDIGNVGQVTATIHPYIKIGENTNHTFEFTEDTKSEGGMKGMNQAAAGLAMTAYDLCTNPDALKAIRDEFEAWKKTQGR
>NC_006582.1|WP_011248492.1|3809468_3810662_-|M20-family-metallopeptidase
MLKNKSITEEKRNIEEAVDRRDSELRQLALNIHAHPELGYQEYKASNWLSTLLEKEGFAVKRGIAGLDTAFTATWTGKAGGPVIGLLAEYDALPGLGHACGHNLIGTSSVGAALALKDAFPELQATIQVIGTPAEEGLGGKVIMCEHGVFNHLDAAMMCHPKNKTMVIRGGLARVGATFKFYGKESHAASAPEKGVSALDALVGAYNAINSLRQFFSDDVRIHGVITHGGDAANIVPGYSEASFLIRCNTRKELEHVKEKVYTAVRQSAAAVGATSKIEEHLIYAERNTNKTLANLFKENLQLMGIEVSPPPLQGGIGSSDIGNVSQLVPTIHPYIKIGEATNHTHDFTNETKSEGGLKGMNQAAKALAMTAYDLCELPGALQRVKEEFANWQLENV
>NC_006582.1|WP_011248493.1|3810729_3812172_-|DASS-family-sodium-coupled-anion-symporter
MSSQLDADNMKKPSKATYKYVVLGVLLLFLFASPFLPVPESMELRGWSALAVVTLGIGLWFTHLLPPAVTAMLLIVLFPLFGVLTFEQSAESLGKEVIWLIIAMLMMGAAVERTGLDKRIAFTILTLTKGNIRLVLLALIFVGFVLTFFLPNAIGRVVVLLPIALGVVQSLAGTGGPNVGKASMFAITYTPIICSVALITGATGSVYAASLFETMLGFEWRYLYWMAVMLPSTLAILLILWLALLWLFPVKAGKHAQGEAYFKQEKEKLGPMSFQEKTLLILYVLLITLWTTQSVHQLSISFSAVLIVIALYIPGIQLMEWKEAVAKVDWSIPLLFSAGFSMAEAFEAGGVVQWSSSLASAHLNGLPAFTLAVSLLLVVAAIRIGFTNLTAMIASLMPVALTFAAGSNVNPVWLGMICLAACSTGFLFPSQSVGTMMTYALGYYTSQELLKVGAILTLSVIVITLLAAFLYWPLIGLPVH
>NC_006582.1|WP_142299545.1|3812229_3813444_-|M20/M25/M40-family-metallo-hydrolase
MVQQTYEALKNDPTIQQGLAFIEEDDEQTLAEQVAMTEIPAPPFKEAERAAYVQQKFSEYGLEAVRRDKEGNVIGAYKGVGDGPVIVLSAHLDTVFPEGTDTKVRRERDRLCAPGIFDDTRGLAEMLSIIRALHRTNVKTSGTIQFVASVGEEGIGDLRGVKAFFADSPNVDAFISIDGTGVGHIVYEGTGSCRYKITYSATGGHSYGDFGLPSAIHAAGRAVAAIADCRPPTEPKTTFTIGEIAGGTAVNAIASSASFHLDVRSTSPQALEQLESTFLKACKQAAEQENRHWQKHDVTVDIKRVGDRPAGRQDKEATIVQAVVQASKELGIAPTLKGAASTDSNIPIHLGIPAVTVGRGGNGGGTHTLGEWFEPVHAYLSPQRTFLAAIALVGVDQVSRPLLA
>NC_006582.1|WP_011248495.1|3813491_3814526_-|ATP-binding-cassette-domain-containing-protein
MIKEVANTKEDDTLLEIKGLKKHFDVTRKIFAKKKDILKAVDGVDFIVKKGETFGIVGESGCGKSTTGNMIMRLADPTAGSIHFEGKDLSKLAKNEQSKMKKDIQMIFQDPFSSLNPRMRVFEIIAEPLRTHKIATGKELKQQVYELLDVVGLDRSLAKRFPHEFSGGQRQRIGIARALALRPKLIVCDEPVSALDVSIQSQVLNLLSKLQKDFDLTYIFIAHGLPVVKHISDRVAVMYLGKIVETAATEELFKHPKHPYTEGLLRAIPVPDPTLRSLDSGELLEGDLPSPVNPPSGCHFRTRCPYANEKCKAEAPKLQEVAKAHYVACHYPLQAGRGVIMEHA
>NC_006582.1|WP_011248496.1|3814522_3815515_-|ABC-transporter-ATP-binding-protein
MARQNRLLEVENLKTYFHTENGTVPSVDGVSFHVDRGETVAIVGESGSGKSVTSFSIMGLVSPPGKIEAGHIRFDGTELTSLSERKMRKVRGNEIAMIFQEPLTSLNPVFTVGHQISEAILLHQDTKKAEARKQGIAMLKRVGIPRAEQVYQSYPHALSGGMRQRVMIAMALSCNPKMLIADEPTTALDVTIQAQILRLLKKISKEVDTSIILITHDLGVVAELVDRVIVMYAGQIVEQADVYTIFKDPKHPYTQGLLESTPKIHELHDELKSIRGVVPVPTNMPTGCRFHPRCPHAMDICKEKEPMMVDRDGKAQVRCWLYASEKEDVG
>NC_006582.1|WP_011248497.1|3815558_3816482_-|ABC-transporter-permease
MQTEQPVKHLRNHTTENRLANWTRRWARLLFKSKTGTIGLIITGLIFLLAIFAPVLSPYHPNVQNYAAMNVPPVWLEGGMKEHLLGTDNLGRDMLSRIIYGTQVSLLVGVCSVVVAGAIGMFFGLIAGYYGGFIDNVLMRIVDAFLAIPNVLFILVILGVLSPGLLTLIFVIGLTNWVIYARLVRGDVLSIKEREFIKAARTIGTKNPVIICKHVLPNVMPSFIVISTLSVATTIVLEASLSYLGLGVQPPTVSWGGMLSAGRDYLATSWWIATFPGLAIMITVLGIIFLGDWLRDVLDPRSQTLRS
>NC_006582.1|WP_011248498.1|3816493_3817411_-|ABC-transporter-permease
MRKYLLWRVLQIIPVLFLISIFVFALLYLAGDPVALMLPEDATQEQVDALRESLGLDQPFYIQYLSFVGDVIQGDFGYSYRYSQPALPIVLERLPATFELAFASMIVAVLIAVPLGILSATKRNTALDVFISGASVLGKAMPNFWLGIMLILMLAITYPFFPVSGSGSVAHLILPAITLGTGCAAEMTRVLRSSMLETLNQDYVRTAVSKGVKNFFVVYKHAFRNALIPFITITFLQVSTLVSGALITEVVFSWPGLGQLLIQAINGRDMAVVQATVFIVAFIVIVVNLMADVLYRVLDPRIQFD
>NC_006582.1|WP_041824853.1|3817481_3819044_-|ABC-transporter-substrate-binding-protein
MQMMPIVVGGLLLSGCMTNEENMTTAPDAGGEGGASSSNDTTLTIAQGSDMVSFDVHDHSNTSTEAIHINMFSYLVKNDVEGEGIVPDLATDWELVDDETWQFTLRDDAVFHNGDPVTAEDVKFTLERVAKDNTLQEHENYRQINEVEVIDDHTFLIHTNGPQPVMLNRLSRLGSGILPKDYIEENGWDHFLQEPVGSGPYQFVEWVRDDRVVLERFDDYFGGDVAVWDQLVFRSIPESSTRVGEVIAGGVDIAMNIAPIDWNRVNENEGTSIVEGQTNRTMMLVPNHREEYPTSDPLVREAIDLAIDNQALLDNLMGGSGTPTLTRVNPGNFGANEALHGEYRYDPDRAKELLEEAGYGDGLELTLHSPDGRYLQDRETTEVIAGMLSEIGIDVKIDFMEWSAYVDLRDAHEQKDLYLIGLTGSLWDAAHQLRHHTSMVAEDHIGYSNEEFDQIYLEAEVNMDEAEREQQYIDLQTMADEELINIMLFQLDSFYAVNDRIQFEPRLDEMWRVEEITLSE

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Crispr_ID: NC_006582_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006582_10

3820899-3821324

Orphan

NA:I-C

Consensus_repeat	Method
ATTTCAATCCACGCACTCACTAAGAGTGCGAC	CRISPRCasFinder
ATTTCAATCCACGCACTCACNNAGAGTGCGAC	CRT
ATTTCAATCCACGCACTCAC	PILER-CR

6 spacers

The CRISPR arrays of NC_006582_10

>merge|NC_006582|10|3820899-3821324|CRISPRCasFinder,CRT,PILER-CR
GATTCAATCGACGCACTCGCATAGAGTGCGACAAGGAATGATGCTTAATGACTCAACTTGAATACATTTCAATCCACGCACTCACATAGAGTGCGACGGACGAAGTTGCACAGAGTAAGCGACGTAGAACAATTTCAATCCACACACTCACATAGAGTGCGACGTGAGAATGAACAAGAGTTCTATCAGGAATGGACTATTTCAATCCACGCACTCACATAGAGTGCGACGCGACAAGGTGATGGATGTAAACCCAGCATCAAAATTTCAATCCACGCACTCACTAAGAGTGCGACTTATATACAAAAGGAGATGATTACATGGCGGCAATTTCAATCCACGCACTCACTAAGAGTGCGACCCTTACATGAAAACGGAGCTTGGTTACTTTGTGATTTCAATCCACGCACTCACTAAGAGTGCGAC

>NC_006582|10|10|3820899-3821324|CRISPRCasFinder
GATTCAATCGACGCACTCGCATAGAGTGCGAC	AAGGAATGATGCTTAATGACTCAACTTGAATAC
ATTTCAATCCACGCACTCACATAGAGTGCGAC	GGACGAAGTTGCACAGAGTAAGCGACGTAGAACA
ATTTCAATCCACACACTCACATAGAGTGCGAC	GTGAGAATGAACAAGAGTTCTATCAGGAATGGACT
ATTTCAATCCACGCACTCACATAGAGTGCGAC	GCGACAAGGTGATGGATGTAAACCCAGCATCAAA
ATTTCAATCCACGCACTCACTAAGAGTGCGAC	TTATATACAAAAGGAGATGATTACATGGCGGCA
ATTTCAATCCACGCACTCACTAAGAGTGCGAC	CCTTACATGAAAACGGAGCTTGGTTACTTTGTG
ATTTCAATCCACGCACTCACTAAGAGTGCGAC

>NC_006582|10|7|3820899-3821324|CRT
GATTCAATCGACGCACTCGCATAGAGTGCGAC	AAGGAATGATGCTTAATGACTCAACTTGAATAC
ATTTCAATCCACGCACTCACATAGAGTGCGAC	GGACGAAGTTGCACAGAGTAAGCGACGTAGAACA
ATTTCAATCCACACACTCACATAGAGTGCGAC	GTGAGAATGAACAAGAGTTCTATCAGGAATGGACT
ATTTCAATCCACGCACTCACATAGAGTGCGAC	GCGACAAGGTGATGGATGTAAACCCAGCATCAAA
ATTTCAATCCACGCACTCACTAAGAGTGCGAC	TTATATACAAAAGGAGATGATTACATGGCGGCA
ATTTCAATCCACGCACTCACTAAGAGTGCGAC	CCTTACATGAAAACGGAGCTTGGTTACTTTGTG
ATTTCAATCCACGCACTCACTAAGAGTGCGAC

>NC_006582|10|8|3820964-3821312|PILER-CR
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACGGACGAAGTTGCACAGAGTAAGCGACGTAGAACA
ATTTCAATCCACACACTCAC	ATAGAGTGCGACGTGAGAATGAACAAGAGTTCTATCAGGAATGGACT
ATTTCAATCCACGCACTCAC	ATAGAGTGCGACGCGACAAGGTGATGGATGTAAACCCAGCATCAAA
ATTTCAATCCACGCACTCAC	TAAGAGTGCGACTTATATACAAAAGGAGATGATTACATGGCGGCA
ATTTCAATCCACGCACTCAC	TAAGAGTGCGACCCTTACATGAAAACGGAGCTTGGTTACTTTGTG
ATTTCAATCCACGCACTCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_006582.1\|WP_011248512.1\|3830311_3831820_+\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225962
NC_006582.1\|WP_011248491.1\|3808223_3809414_-\|M20-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349883
NC_006582.1\|WP_011248501.1\|3821607_3822504_-\|N-acetylglucosamine-kinase	unknown	unknown	gnl\|CDD\|225518
NC_006582.1\|WP_011248505.1\|3824454_3825723_+\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NC_006582.1\|WP_011248507.1\|3826079_3827396_+\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|133432
NC_006582.1\|WP_011248497.1\|3815558_3816482_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_006582.1\|WP_011248506.1\|3825781_3826087_+\|hypothetical-protein	unknown	unknown	unknown
NC_006582.1\|WP_011248502.1\|3822508_3823594_-\|DUF871-domain-containing-protein	unknown	unknown	gnl\|CDD\|377567
NC_006582.1\|WP_011248498.1\|3816493_3817411_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_006582.1\|WP_011248504.1\|3824121_3824430_+\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99906
NC_006582.1\|WP_011248495.1\|3813491_3814526_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|185037
NC_006582.1\|WP_011248510.1\|3828583_3829399_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_006582.1\|WP_011248496.1\|3814522_3815515_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NC_006582.1\|WP_011248503.1\|3823596_3823935_-\|PTS-lactose/cellobiose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|376749
NC_006582.1\|WP_011248493.1\|3810729_3812172_-\|DASS-family-sodium-coupled-anion-symporter	unknown	unknown	gnl\|CDD\|273267
NC_006582.1\|WP_142299545.1\|3812229_3813444_-\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349891
NC_006582.1\|WP_011248511.1\|3829820_3830312_+\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225937
NC_006582.1\|WP_011248500.1\|3819789_3820665_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_006582.1\|WP_041824853.1\|3817481_3819044_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173863
NC_006582.1\|WP_011248492.1\|3809468_3810662_-\|M20-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349883

Protein	Function_ID	Function_description	E-value
NC_006582.1\|WP_011248512.1\|3830311_3831820_+\|PH-domain-containing-protein	gnl\|CDD\|225962	COG3428, COG3428, Predicted membrane protein [Function unknown].	9.64446e-48
NC_006582.1\|WP_011248491.1\|3808223_3809414_-\|M20-family-metallopeptidase	gnl\|CDD\|349883	cd03887, M20_Acy1L2, M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family. Peptidase M20 family, Aminoacylase 1-like protein 2 (ACY1L2; amidohydrolase) subfamily. This group contains many uncharacterized proteins predicted as amidohydrolases, including gene products of abgA and abgB that catalyze the cleavage of p-aminobenzoyl-glutamate, a folate catabolite in Escherichia coli, to p-aminobenzoate and glutamate. p-Aminobenzoyl-glutamate utilization is catalyzed by the abg region gene product, AbgT. Aminoacylase 1 (ACY1) proteins are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	1.29307e-150
NC_006582.1\|WP_011248501.1\|3821607_3822504_-\|N-acetylglucosamine-kinase	gnl\|CDD\|225518	COG2971, COG2971, Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism].	3.69717e-33
NC_006582.1\|WP_011248505.1\|3824454_3825723_+\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	1.01631e-147
NC_006582.1\|WP_011248507.1\|3826079_3827396_+\|6-phospho-beta-glucosidase	gnl\|CDD\|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NC_006582.1\|WP_011248497.1\|3815558_3816482_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.00257e-105
NC_006582.1\|WP_011248502.1\|3822508_3823594_-\|DUF871-domain-containing-protein	gnl\|CDD\|377567	pfam05913, DUF871, Bacterial protein of unknown function (DUF871). This family consists of several conserved hypothetical proteins from bacteria and archaea. The function of this family is unknown.	0
NC_006582.1\|WP_011248498.1\|3816493_3817411_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	8.41585e-123
NC_006582.1\|WP_011248504.1\|3824121_3824430_+\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99906	cd05564, PTS_IIB_chitobiose_lichenan, PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	6.07087e-37
NC_006582.1\|WP_011248495.1\|3813491_3814526_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|185037	PRK15079, PRK15079, oligopeptide ABC transporter ATP-binding protein OppF; Provisional.	2.10518e-150
NC_006582.1\|WP_011248510.1\|3828583_3829399_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.82002e-10
NC_006582.1\|WP_011248496.1\|3814522_3815515_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	0
NC_006582.1\|WP_011248503.1\|3823596_3823935_-\|PTS-lactose/cellobiose-transporter-subunit-IIA	gnl\|CDD\|376749	pfam02255, PTS_IIA, PTS system, Lactose/Cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.	3.0484e-35
NC_006582.1\|WP_011248493.1\|3810729_3812172_-\|DASS-family-sodium-coupled-anion-symporter	gnl\|CDD\|273267	TIGR00785, Uncharacterized_transporter_HI_0020, anion transporter. The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds].	5.07676e-45
NC_006582.1\|WP_142299545.1\|3812229_3813444_-\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|349891	cd03896, M20_PAAh_like, M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins. Peptidase M20 family, Poly(aspartic acid) hydrolase (PAA hydrolase)-like subfamily. PAA hydrolase enzymes are involved in alpha,beta-poly(D,L-aspartic acid) (tPAA) biodegradation. PAA is being extensively studied as a replacement for commercial polycarboxylate components since it can be degraded by enzymes from isolated tPAA degrading bacteria. Thus far, two types of PAA degrading bacteria (Sphingomonas sp. KT-1 and Pedobacter sp. KP-2) have been investigated in detail; the former can completely degrade tPAA of low-molecular weights below 5000, while the latter can degrade high molecular weight tPAA to release oligo(aspartic acid) (OAA) as a product, suggesting two kinds of PAA degrading enzymes. It has been shown that PAA hydrolase-1 from Sphingomonas sp. KT-1 hydrolyzes beta,beta-aspartic acid units in tPAA to produce OAA, and it is suggested that PAA hydrolase-2 hydrolyzes OAA to aspartic acid. Also included in this family is Bradyrhizobium 5-nitroanthranilic acid (5NAA)-aminohydrolase (5NAA-A), a biodegradation enzyme that converts 5NAA to 5-nitrosalicylic acid; 5NAA is a metabolite secreted by Streptomyces scabies, the bacterium responsible for potato scab, and metabolized by Bradyrhizobium species strain JS329.	3.57695e-94
NC_006582.1\|WP_011248511.1\|3829820_3830312_+\|PH-domain-containing-protein	gnl\|CDD\|225937	COG3402, COG3402, Uncharacterized conserved protein [Function unknown].	6.46504e-28
NC_006582.1\|WP_011248500.1\|3819789_3820665_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.92403e-51
NC_006582.1\|WP_041824853.1\|3817481_3819044_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173863	cd08498, PBP2_NikA_DppA_OppA_like_2, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NC_006582.1\|WP_011248492.1\|3809468_3810662_-\|M20-family-metallopeptidase	gnl\|CDD\|349883	cd03887, M20_Acy1L2, M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family. Peptidase M20 family, Aminoacylase 1-like protein 2 (ACY1L2; amidohydrolase) subfamily. This group contains many uncharacterized proteins predicted as amidohydrolases, including gene products of abgA and abgB that catalyze the cleavage of p-aminobenzoyl-glutamate, a folate catabolite in Escherichia coli, to p-aminobenzoate and glutamate. p-Aminobenzoyl-glutamate utilization is catalyzed by the abg region gene product, AbgT. Aminoacylase 1 (ACY1) proteins are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	8.31633e-160

>NC_006582.1|WP_011248500.1|3819789_3820665_+|LysR-family-transcriptional-regulator
MNEKDWELLQTLYEMKNITKAAEKLFISQPALTYRLRSLENEFGVEIAKRGTKRLQFTSEGEYLVEYSRKMLNELAKTKDQLLNMAGNIQGHLRIGVSSHFAHYRLPTILKDFLAVYPNVQVNVTTGWSTKISQKLERKEVHIGIIRGSYEWKEQSILLNEENVCLISKNKIHMGDLPSIGRISYKTDPIFDNMIKDWWNHHFSQPPMVTMEVDRIETCKEMVRNGLGYAIIPQISLRPHDQLYNRILAIDNHPLLRKTWLIYSNSALDLSVVKAFVQFVTTQLRQQAHSL
>NC_006582.1|WP_041824853.1|3817481_3819044_-|ABC-transporter-substrate-binding-protein
MQMMPIVVGGLLLSGCMTNEENMTTAPDAGGEGGASSSNDTTLTIAQGSDMVSFDVHDHSNTSTEAIHINMFSYLVKNDVEGEGIVPDLATDWELVDDETWQFTLRDDAVFHNGDPVTAEDVKFTLERVAKDNTLQEHENYRQINEVEVIDDHTFLIHTNGPQPVMLNRLSRLGSGILPKDYIEENGWDHFLQEPVGSGPYQFVEWVRDDRVVLERFDDYFGGDVAVWDQLVFRSIPESSTRVGEVIAGGVDIAMNIAPIDWNRVNENEGTSIVEGQTNRTMMLVPNHREEYPTSDPLVREAIDLAIDNQALLDNLMGGSGTPTLTRVNPGNFGANEALHGEYRYDPDRAKELLEEAGYGDGLELTLHSPDGRYLQDRETTEVIAGMLSEIGIDVKIDFMEWSAYVDLRDAHEQKDLYLIGLTGSLWDAAHQLRHHTSMVAEDHIGYSNEEFDQIYLEAEVNMDEAEREQQYIDLQTMADEELINIMLFQLDSFYAVNDRIQFEPRLDEMWRVEEITLSE
>NC_006582.1|WP_011248498.1|3816493_3817411_-|ABC-transporter-permease
MRKYLLWRVLQIIPVLFLISIFVFALLYLAGDPVALMLPEDATQEQVDALRESLGLDQPFYIQYLSFVGDVIQGDFGYSYRYSQPALPIVLERLPATFELAFASMIVAVLIAVPLGILSATKRNTALDVFISGASVLGKAMPNFWLGIMLILMLAITYPFFPVSGSGSVAHLILPAITLGTGCAAEMTRVLRSSMLETLNQDYVRTAVSKGVKNFFVVYKHAFRNALIPFITITFLQVSTLVSGALITEVVFSWPGLGQLLIQAINGRDMAVVQATVFIVAFIVIVVNLMADVLYRVLDPRIQFD
>NC_006582.1|WP_011248497.1|3815558_3816482_-|ABC-transporter-permease
MQTEQPVKHLRNHTTENRLANWTRRWARLLFKSKTGTIGLIITGLIFLLAIFAPVLSPYHPNVQNYAAMNVPPVWLEGGMKEHLLGTDNLGRDMLSRIIYGTQVSLLVGVCSVVVAGAIGMFFGLIAGYYGGFIDNVLMRIVDAFLAIPNVLFILVILGVLSPGLLTLIFVIGLTNWVIYARLVRGDVLSIKEREFIKAARTIGTKNPVIICKHVLPNVMPSFIVISTLSVATTIVLEASLSYLGLGVQPPTVSWGGMLSAGRDYLATSWWIATFPGLAIMITVLGIIFLGDWLRDVLDPRSQTLRS
>NC_006582.1|WP_011248496.1|3814522_3815515_-|ABC-transporter-ATP-binding-protein
MARQNRLLEVENLKTYFHTENGTVPSVDGVSFHVDRGETVAIVGESGSGKSVTSFSIMGLVSPPGKIEAGHIRFDGTELTSLSERKMRKVRGNEIAMIFQEPLTSLNPVFTVGHQISEAILLHQDTKKAEARKQGIAMLKRVGIPRAEQVYQSYPHALSGGMRQRVMIAMALSCNPKMLIADEPTTALDVTIQAQILRLLKKISKEVDTSIILITHDLGVVAELVDRVIVMYAGQIVEQADVYTIFKDPKHPYTQGLLESTPKIHELHDELKSIRGVVPVPTNMPTGCRFHPRCPHAMDICKEKEPMMVDRDGKAQVRCWLYASEKEDVG
>NC_006582.1|WP_011248495.1|3813491_3814526_-|ATP-binding-cassette-domain-containing-protein
MIKEVANTKEDDTLLEIKGLKKHFDVTRKIFAKKKDILKAVDGVDFIVKKGETFGIVGESGCGKSTTGNMIMRLADPTAGSIHFEGKDLSKLAKNEQSKMKKDIQMIFQDPFSSLNPRMRVFEIIAEPLRTHKIATGKELKQQVYELLDVVGLDRSLAKRFPHEFSGGQRQRIGIARALALRPKLIVCDEPVSALDVSIQSQVLNLLSKLQKDFDLTYIFIAHGLPVVKHISDRVAVMYLGKIVETAATEELFKHPKHPYTEGLLRAIPVPDPTLRSLDSGELLEGDLPSPVNPPSGCHFRTRCPYANEKCKAEAPKLQEVAKAHYVACHYPLQAGRGVIMEHA
>NC_006582.1|WP_142299545.1|3812229_3813444_-|M20/M25/M40-family-metallo-hydrolase
MVQQTYEALKNDPTIQQGLAFIEEDDEQTLAEQVAMTEIPAPPFKEAERAAYVQQKFSEYGLEAVRRDKEGNVIGAYKGVGDGPVIVLSAHLDTVFPEGTDTKVRRERDRLCAPGIFDDTRGLAEMLSIIRALHRTNVKTSGTIQFVASVGEEGIGDLRGVKAFFADSPNVDAFISIDGTGVGHIVYEGTGSCRYKITYSATGGHSYGDFGLPSAIHAAGRAVAAIADCRPPTEPKTTFTIGEIAGGTAVNAIASSASFHLDVRSTSPQALEQLESTFLKACKQAAEQENRHWQKHDVTVDIKRVGDRPAGRQDKEATIVQAVVQASKELGIAPTLKGAASTDSNIPIHLGIPAVTVGRGGNGGGTHTLGEWFEPVHAYLSPQRTFLAAIALVGVDQVSRPLLA
>NC_006582.1|WP_011248493.1|3810729_3812172_-|DASS-family-sodium-coupled-anion-symporter
MSSQLDADNMKKPSKATYKYVVLGVLLLFLFASPFLPVPESMELRGWSALAVVTLGIGLWFTHLLPPAVTAMLLIVLFPLFGVLTFEQSAESLGKEVIWLIIAMLMMGAAVERTGLDKRIAFTILTLTKGNIRLVLLALIFVGFVLTFFLPNAIGRVVVLLPIALGVVQSLAGTGGPNVGKASMFAITYTPIICSVALITGATGSVYAASLFETMLGFEWRYLYWMAVMLPSTLAILLILWLALLWLFPVKAGKHAQGEAYFKQEKEKLGPMSFQEKTLLILYVLLITLWTTQSVHQLSISFSAVLIVIALYIPGIQLMEWKEAVAKVDWSIPLLFSAGFSMAEAFEAGGVVQWSSSLASAHLNGLPAFTLAVSLLLVVAAIRIGFTNLTAMIASLMPVALTFAAGSNVNPVWLGMICLAACSTGFLFPSQSVGTMMTYALGYYTSQELLKVGAILTLSVIVITLLAAFLYWPLIGLPVH
>NC_006582.1|WP_011248492.1|3809468_3810662_-|M20-family-metallopeptidase
MLKNKSITEEKRNIEEAVDRRDSELRQLALNIHAHPELGYQEYKASNWLSTLLEKEGFAVKRGIAGLDTAFTATWTGKAGGPVIGLLAEYDALPGLGHACGHNLIGTSSVGAALALKDAFPELQATIQVIGTPAEEGLGGKVIMCEHGVFNHLDAAMMCHPKNKTMVIRGGLARVGATFKFYGKESHAASAPEKGVSALDALVGAYNAINSLRQFFSDDVRIHGVITHGGDAANIVPGYSEASFLIRCNTRKELEHVKEKVYTAVRQSAAAVGATSKIEEHLIYAERNTNKTLANLFKENLQLMGIEVSPPPLQGGIGSSDIGNVSQLVPTIHPYIKIGEATNHTHDFTNETKSEGGLKGMNQAAKALAMTAYDLCELPGALQRVKEEFANWQLENV
>NC_006582.1|WP_011248491.1|3808223_3809414_-|M20-family-metallopeptidase
MATTILAEKQEILTALDQRDEELRELALMIHANPELSFKEYKAAEWLSAYLEKEGFQVERGTAGLETAFTAIWEGNPGGPVIGILAEYDALPNLGHACGHNLIGTAAVGAAVALKDAYPELQGTIKVIGTPAEEGGGGKIYMCDHGTFNDLDAAMMVHPKNKTMVLRGGLACMTATFSFYGKESHAASAPEKGISALDALIQSYNAINSLRQFFTDDVRIHGIITKGGDAANIVPGHCEAQFIIRAATTNRLHEIKEKVYEAVRHSSQSVGAKYKIEEGLIYAERNNNHALAELFKQNWEAMGIEVEDPPKQGGIGSSDIGNVGQVTATIHPYIKIGENTNHTFEFTEDTKSEGGMKGMNQAAAGLAMTAYDLCTNPDALKAIRDEFEAWKKTQGR
>NC_006582.1|WP_011248501.1|3821607_3822504_-|N-acetylglucosamine-kinase
MYVIGLDAGGTKTHGAVIDQEQNIHFSIETGPGNVAVDSEKAKEHIMAAIQACIQSKYGSLCKAIVLGIAGIEKGHLKSEFKTLVEQHFQLPALMLNDAELALYAVLEDENGVLAIAGTGSVLIGKKDATIKMVGGWGHLLGDEGSAYHIGIQALKQLASEIEQGTIQTKLAKALATQYQLPDASAVKEFVYSSTKKEIADIALFVYRRAQDDTDAKKLLEQAGEELAQQAIRLVTQLELETSSIPIIVKGSLLEKNEFVRHHFAEKLKQCSADISIVCKNRPAVTGALHAWKISNHH
>NC_006582.1|WP_011248502.1|3822508_3823594_-|DUF871-domain-containing-protein
MQQLGISIYPNHSTAEKDKQYIHVANQYGFTRVFTCLLSVEQDNILASFQETIHYAKQLGMEVICDINPRVFKDLGISYDDLTFFKNLGADGIRLDLGFTGNEESMMTFNPHGLFIEVNMSNSTKYIDNILSFQPNRNKLIGCHNFYPHRYSGLSYDFFIECSEKFKKYGLRTAAFVSSQAATFGPWPIVEGLPTLEMHRGLPIDVQAKHLFATRLIDDVIIGNAYASEEELKRLSQINKAKLTFNLELVDSVSDLEKKILFDEPHFYRGDVSDYMIRSTQSRVKYRGEAFPPHNTTDIKRGDVVIESELYEQYAGELQIALKDMTNSGRTNVVARIREEEIFLIDSLKPWDKFAFSEWDG
>NC_006582.1|WP_011248503.1|3823596_3823935_-|PTS-lactose/cellobiose-transporter-subunit-IIA
MNVEVEIFNMISNAGDAKSIAYEALKLAQNNDFHLANEKLETANKTLAKAHNTQTKLIQAEINGEHVEQSLLMVHAQDHLMAAISEMSLIEQMIAILRRVAQLEARSESESV
>NC_006582.1|WP_011248504.1|3824121_3824430_+|PTS-sugar-transporter-subunit-IIB
MTKVLFVCSGGMSSAIVVNTLKKEAEKHGQALEVKAIGSSEVAAELENNWDVVMVAPQIKHRFDNIKKEADAYGVPCGPIPPQAYTPLGGPTLLKTLQELVK
>NC_006582.1|WP_011248505.1|3824454_3825723_+|PTS-sugar-transporter-subunit-IIC
MGKFIDFLEKRVSNPMARLAEQRHLLAVRDGVVSSLPFIIVGSFFLIIAFPPLPESWGMTQWATENADQILIPYRMTMFIMSLYVAFGIGYNLAQSYKVDPLSGGQIAVASLLLTITPSVVEELGFVLPMQYLGGSGLFVTIIVSILSVEIFRICKQRNITIRLPEAVPASVSRSFEALIPVAIVIMLMTLITIIMGVNLHALVEKLTVPLVTAGDSLFGVLVPVFLITFFWSFGIHGVSVVGSVARPLWETYLLKNGEAVASGASELPHIAPEPLYQWFIWIGGSGATLGLVIVMLIFARSKYLKSLGRTVAVPSIFNINEPVIFGLPIVLNPILVIPFIITPIITAVIAYLATSVGLVSPTFIKAPWTLPAPIGAYLATGGDWRSIILVLVNLAISVVIYLPFLRIYDKKMLAMEQNEEQ
>NC_006582.1|WP_011248506.1|3825781_3826087_+|hypothetical-protein
MEQSRLIPRISPKGVFVFMMILFFGMLLLSIPLKYIHLSETMSAFLSAGISAAIGIGIVLTKIDGKTTDKRLNRQRIRIAIIVGFATSALMTFVFGGDLLG
>NC_006582.1|WP_011248507.1|3826079_3827396_+|6-phospho-beta-glucosidase
MGKKGIKIVTIGGGSSYTPEFVEGLIKRHKELPVRELWLVDIEKGKEKLEIVGNLAKRMVKKAGLPITIYTTFDRKEALKDADFVTTQMRVGLLEARIKDERIPLKHGMIGQETNGAGGLFKALRTIPVLLEIAEQMHELCPNAWLINFTNPAGIVTEAVMKYSQHKKIIGVCNVPINTKMTIATLLDVPPDQLTITFAGLNHMSYGLDVHVNGESRLNDVIDLVTDPNHEVTMKNIIPLPWEKAFMKALGCIPSPYHRYYYKTNEILQKELEEFKQGKTRAEVVKQLEDELFELYKDPDLDIKPPQLEKRGGAYYSDAACNLISSIYNDKGDVQTLNTRNEGAITNLPNDTVVEVNCVVTKQGPIPLAIGELPYSINGLIQQIKSFELVAIEAAVTGSYEQALLALCINPLITSDVKAKDILDEMLEAHKTDLPQFQ
>NC_006582.1|WP_011248510.1|3828583_3829399_+|CPBP-family-intramembrane-metalloprotease
MKKLASTILKTIIFFMSWAILISFTPDIHTNSQAYLRLWWEFTPLVVVVLLSVVFVFIVEKGKITIPVAPRFLKSSLIGIVLGVLWLGSVVTVFLLTKTMNIQGQNSVDYIWIWILASLLNVAMQELLVRGYLYQLWKHKYNVIVATILTTILFTVMHGGAFEAGMIPVINVISMSIFVTLLLEYTGTIVAPIIIHFIWNTIGAIILGGVSLAGDYPNLLINTFQGSLLISGGTYKFEGSIIVSIANLILITSLLVLNKRKRNDNLSGLLK
>NC_006582.1|WP_011248511.1|3829820_3830312_+|PH-domain-containing-protein
MSIPINAPQKRLSKDAIKVWLISDAIGNMIVLIILGILFYLDDRFLWKEWVGWLLIGATVLTIIGWIWSVIRPFLLYKHWRYDVDEAYLQLKSGALKETHELVPMTKIQSVATEQGPLLRKYGLCSVSVETMGSSHTIPALPKEAAVELRNQIAQYARIKEVE
>NC_006582.1|WP_011248512.1|3830311_3831820_+|PH-domain-containing-protein
MTKAKRYSPYTMLFHLINLVRNAFFFVIYLYVVMAGSESAFIKYGRMAFWIIVGLILFSIIYKWVTHKYKLDEQSFHLYKGLFSKTEQTIPFSKIENINRHTSFLHRIFKRTSIHFEIAMTGENAHIKFEVLSKAEAEQIEAHIKRATDEELEDWNHPSHDPNDEEAHPRDPDQERTIHFQPTKRDILKASVTSLSFLVLIPLIGSFYFKINDLFHVEDTTEGLINKLASSWWIVAVIIIVLIVVSTIFGLIRTYVKYGKYEIVSDATHIYINRGVIDESAFSISKDKVQAIEIEQSMVKRLLGLAEVKLTSAGGLRSGEEALEKNTLYPFLPVNKAYEMISDMLPSYTITTEMTRLPTKSLWLRILRPSWFWLLATGALFYFKPAIFNIEQSWIIVSAALLVYLLIARLFDFFHTRYAINDHFIQFKTGAFTTSLFVSKREKVIKAKITRNILQKRLGLASIETTNRGNPVRHSGINDVPVELAHSFLQWYRGRKNDITVE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_006582_2	2.12\|3669206\|34\|NC_006582\|CRT,CRISPRCasFinder,PILER-CR	3669206-3669239	34	NC_006582.1	2970380-2970413	0	1.0
NC_006582_3	3.8\|3721347\|35\|NC_006582\|PILER-CR	3721347-3721381	35	NC_006582.1	2960460-2960494	0	1.0
NC_006582_3	3.23\|3721340\|35\|NC_006582\|CRISPRCasFinder,CRT	3721340-3721374	35	NC_006582.1	2960460-2960494	0	1.0
NC_006582_4	4.14\|3729057\|35\|NC_006582\|CRISPRCasFinder	3729057-3729091	35	NC_006582.1	2981036-2981070	0	1.0
NC_006582_4	4.20\|3729457\|33\|NC_006582\|CRISPRCasFinder	3729457-3729489	33	NC_006582.1	2961922-2961954	0	1.0
NC_006582_5	5.13\|3740015\|33\|NC_006582\|CRISPRCasFinder,CRT,PILER-CR	3740015-3740047	33	NC_006582.1	2989964-2989996	0	1.0
NC_006582_5	5.17\|3740281\|34\|NC_006582\|CRISPRCasFinder,CRT,PILER-CR	3740281-3740314	34	NC_006582.1	2977361-2977394	0	1.0
NC_006582_7	7.2\|3751997\|35\|NC_006582\|PILER-CR,CRISPRCasFinder,CRT	3751997-3752031	35	NC_006582.1	2562988-2563022	0	1.0
NC_006582_1	1.1\|1676267\|37\|NC_006582\|CRISPRCasFinder	1676267-1676303	37	NC_006582.1	3974866-3974902	1	0.973
NC_006582_1	1.1\|1676267\|37\|NC_006582\|CRISPRCasFinder	1676267-1676303	37	NC_006582.1	1728774-1728810	1	0.973
NC_006582_5	5.14\|3740080\|36\|NC_006582\|CRISPRCasFinder,CRT,PILER-CR	3740080-3740115	36	NC_006582.1	2949502-2949537	1	0.972

1. spacer 2.12|3669206|34|NC_006582|CRT,CRISPRCasFinder,PILER-CR matches to position: 2970380-2970413, mismatch: 0, identity: 1.0

aaggcgattgactattacctgggagagtcaaccg	CRISPR spacer
aaggcgattgactattacctgggagagtcaaccg	Protospacer
**********************************

2. spacer 3.8|3721347|35|NC_006582|PILER-CR matches to position: 2960460-2960494, mismatch: 0, identity: 1.0

aagaagcaatcaaaggcttagtcaaaggaatgcaa	CRISPR spacer
aagaagcaatcaaaggcttagtcaaaggaatgcaa	Protospacer
***********************************

3. spacer 3.23|3721340|35|NC_006582|CRISPRCasFinder,CRT matches to position: 2960460-2960494, mismatch: 0, identity: 1.0

aagaagcaatcaaaggcttagtcaaaggaatgcaa	CRISPR spacer
aagaagcaatcaaaggcttagtcaaaggaatgcaa	Protospacer
***********************************

4. spacer 4.14|3729057|35|NC_006582|CRISPRCasFinder matches to position: 2981036-2981070, mismatch: 0, identity: 1.0

gatttagaacgcgaaaaggtgccggggcgggtaag	CRISPR spacer
gatttagaacgcgaaaaggtgccggggcgggtaag	Protospacer
***********************************

5. spacer 4.20|3729457|33|NC_006582|CRISPRCasFinder matches to position: 2961922-2961954, mismatch: 0, identity: 1.0

gcgaggatttcaagcgggaattaaatccactgt	CRISPR spacer
gcgaggatttcaagcgggaattaaatccactgt	Protospacer
*********************************

6. spacer 5.13|3740015|33|NC_006582|CRISPRCasFinder,CRT,PILER-CR matches to position: 2989964-2989996, mismatch: 0, identity: 1.0

taatgataggcaattgcttcattacgcaaaaga	CRISPR spacer
taatgataggcaattgcttcattacgcaaaaga	Protospacer
*********************************

7. spacer 5.17|3740281|34|NC_006582|CRISPRCasFinder,CRT,PILER-CR matches to position: 2977361-2977394, mismatch: 0, identity: 1.0

ggccatttcaagaaattgtacaaataccatgagg	CRISPR spacer
ggccatttcaagaaattgtacaaataccatgagg	Protospacer
**********************************

8. spacer 7.2|3751997|35|NC_006582|PILER-CR,CRISPRCasFinder,CRT matches to position: 2562988-2563022, mismatch: 0, identity: 1.0

aaaatagaatcgatttgcgttttaggagacgccgc	CRISPR spacer
aaaatagaatcgatttgcgttttaggagacgccgc	Protospacer
***********************************

9. spacer 1.1|1676267|37|NC_006582|CRISPRCasFinder matches to position: 3974866-3974902, mismatch: 1, identity: 0.973

gaggttgtcgacaaagtcgataaccgccatcagactg	CRISPR spacer
gaggttgtcgacaaagtcgataaccgccctcagactg	Protospacer
**************************** ********

10. spacer 1.1|1676267|37|NC_006582|CRISPRCasFinder matches to position: 1728774-1728810, mismatch: 1, identity: 0.973

gaggttgtcgacaaagtcgataaccgccatcagactg	CRISPR spacer
gaggttgtcgacaaagtcgataaccgccctcagactg	Protospacer
**************************** ********

11. spacer 5.14|3740080|36|NC_006582|CRISPRCasFinder,CRT,PILER-CR matches to position: 2949502-2949537, mismatch: 1, identity: 0.972

gatgaccgctttaccacacaagagggtatcgatgca	CRISPR spacer
gatgaccgctttaccacgcaagagggtatcgatgca	Protospacer
*****************.******************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_006582_4	4.13\|3728991\|34\|NC_006582\|CRISPRCasFinder	3728991-3729024	34	NC_004669	Enterococcus faecalis V583 plasmid pTEF1, complete sequence	27683-27716	6	0.824
NC_006582_4	4.13\|3728991\|34\|NC_006582\|CRISPRCasFinder	3728991-3729024	34	CP002494	Enterococcus faecalis 62 plasmid EF62pC, complete sequence	41725-41758	6	0.824
NC_006582_4	4.13\|3728991\|34\|NC_006582\|CRISPRCasFinder	3728991-3729024	34	NZ_CP031029	Enterococcus faecalis strain TY1 isolate flatfish plasmid pDEF-2, complete sequence	43655-43688	6	0.824
NC_006582_4	4.13\|3728991\|34\|NC_006582\|CRISPRCasFinder	3728991-3729024	34	NZ_CP019513	Enterococcus faecalis strain CLB21560 plasmid pA, complete sequence	66502-66535	6	0.824
NC_006582_4	4.13\|3728991\|34\|NC_006582\|CRISPRCasFinder	3728991-3729024	34	NZ_CP028838	Enterococcus faecalis strain FC plasmid unnamed3, complete sequence	18674-18707	6	0.824
NC_006582_4	4.13\|3728991\|34\|NC_006582\|CRISPRCasFinder	3728991-3729024	34	NZ_CP028721	Enterococcus faecalis strain CVM N48037F plasmid pN48037F-1, complete sequence	1359-1392	6	0.824
NC_006582_4	4.13\|3728991\|34\|NC_006582\|CRISPRCasFinder	3728991-3729024	34	NZ_CP028286	Enterococcus faecalis strain FDAARGOS_324 plasmid unnamed1, complete sequence	41810-41843	6	0.824
NC_006582_4	4.13\|3728991\|34\|NC_006582\|CRISPRCasFinder	3728991-3729024	34	NC_002630	Enterococcus faecalis plasmid pAM373, complete sequence	24054-24087	6	0.824
NC_006582_4	4.13\|3728991\|34\|NC_006582\|CRISPRCasFinder	3728991-3729024	34	NZ_KY270848	Enterococcus faecalis strain 2 plasmid pGTC2, complete sequence	40799-40832	7	0.794
NC_006582_4	4.20\|3729457\|33\|NC_006582\|CRISPRCasFinder	3729457-3729489	33	NC_023560	Oenococcus phage phiS13, complete genome	23072-23104	7	0.788
NC_006582_5	5.19\|3739304\|29\|NC_006582\|PILER-CR	3739304-3739332	29	NZ_CP024940	Paraburkholderia hospita strain mHSR1 plasmid pmHSR1_P, complete sequence	1106690-1106718	7	0.759
NC_006582_4	4.13\|3728991\|34\|NC_006582\|CRISPRCasFinder	3728991-3729024	34	NZ_CP021876	Enterococcus wangshanyuanii strain MN05 plasmid unnamed3	72541-72574	8	0.765
NC_006582_4	4.20\|3729457\|33\|NC_006582\|CRISPRCasFinder	3729457-3729489	33	NC_023559	Oenococcus phage phi9805, complete genome	23476-23508	8	0.758
NC_006582_6	6.2\|3741138\|35\|NC_006582\|CRISPRCasFinder,PILER-CR	3741138-3741172	35	MN855646	Bacteriophage sp. isolate 226, complete genome	8806-8840	8	0.771
NC_006582_5	5.16\|3740214\|35\|NC_006582\|CRISPRCasFinder,CRT,PILER-CR	3740214-3740248	35	MH572403	Microviridae sp. isolate SD_SF_37, complete genome	3898-3932	10	0.714
NC_006582_5	5.16\|3740214\|35\|NC_006582\|CRISPRCasFinder,CRT,PILER-CR	3740214-3740248	35	MH617146	Microviridae sp. isolate ctdb64, complete genome	3885-3919	10	0.714
NC_006582_2	2.2\|3668543\|33\|NC_006582\|CRT,CRISPRCasFinder	3668543-3668575	33	NZ_CP020952	Rhizobium sp. CIAT894 plasmid pRheCIAT894e, complete sequence	654970-655002	11	0.667
NC_006582_5	5.17\|3740281\|34\|NC_006582\|CRISPRCasFinder,CRT,PILER-CR	3740281-3740314	34	NZ_LR214939	Mycoplasma salivarium strain NCTC10113 plasmid 2	387347-387380	11	0.676
NC_006582_6	6.4\|3741272\|34\|NC_006582\|CRISPRCasFinder,PILER-CR	3741272-3741305	34	NZ_CP048306	Escherichia coli strain 9 plasmid p009_B, complete sequence	106685-106718	11	0.676

1. spacer 4.13|3728991|34|NC_006582|CRISPRCasFinder matches to NC_004669 (Enterococcus faecalis V583 plasmid pTEF1, complete sequence) position: , mismatch: 6, identity: 0.824

tgggtcttttgtcaaacgtccaactaaatttact	CRISPR spacer
tgggtcttttgttaatcgtccaactaatgtaacg	Protospacer
************.** ***********  * **

2. spacer 4.13|3728991|34|NC_006582|CRISPRCasFinder matches to CP002494 (Enterococcus faecalis 62 plasmid EF62pC, complete sequence) position: , mismatch: 6, identity: 0.824

tgggtcttttgtcaaacgtccaactaaatttact	CRISPR spacer
tgggtcttttgttaatcgtccaactaacgtaacg	Protospacer
************.** ***********  * **

3. spacer 4.13|3728991|34|NC_006582|CRISPRCasFinder matches to NZ_CP031029 (Enterococcus faecalis strain TY1 isolate flatfish plasmid pDEF-2, complete sequence) position: , mismatch: 6, identity: 0.824

tgggtcttttgtcaaacgtccaactaaatttact	CRISPR spacer
tgggtcttttgttaatcgtccaactaatgtaacg	Protospacer
************.** ***********  * **

4. spacer 4.13|3728991|34|NC_006582|CRISPRCasFinder matches to NZ_CP019513 (Enterococcus faecalis strain CLB21560 plasmid pA, complete sequence) position: , mismatch: 6, identity: 0.824

tgggtcttttgtcaaacgtccaactaaatttact	CRISPR spacer
tgggtcttttgttaatcgtccaactaatgtaacg	Protospacer
************.** ***********  * **

5. spacer 4.13|3728991|34|NC_006582|CRISPRCasFinder matches to NZ_CP028838 (Enterococcus faecalis strain FC plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.824

tgggtcttttgtcaaacgtccaactaaatttact	CRISPR spacer
tgggtcttttgttaatcgtccaactaacgtaacg	Protospacer
************.** ***********  * **

6. spacer 4.13|3728991|34|NC_006582|CRISPRCasFinder matches to NZ_CP028721 (Enterococcus faecalis strain CVM N48037F plasmid pN48037F-1, complete sequence) position: , mismatch: 6, identity: 0.824

tgggtcttttgtcaaacgtccaactaaatttact	CRISPR spacer
tgggtcttttgttaatcgtccaactaacgtaacg	Protospacer
************.** ***********  * **

7. spacer 4.13|3728991|34|NC_006582|CRISPRCasFinder matches to NZ_CP028286 (Enterococcus faecalis strain FDAARGOS_324 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.824

tgggtcttttgtcaaacgtccaactaaatttact	CRISPR spacer
tgggtcttttgttaatcgtccaactaacgtaacg	Protospacer
************.** ***********  * **

8. spacer 4.13|3728991|34|NC_006582|CRISPRCasFinder matches to NC_002630 (Enterococcus faecalis plasmid pAM373, complete sequence) position: , mismatch: 6, identity: 0.824

tgggtcttttgtcaaacgtccaactaaatttact	CRISPR spacer
tgggtcttttgttaatcgtccaactaacgtaacg	Protospacer
************.** ***********  * **

9. spacer 4.13|3728991|34|NC_006582|CRISPRCasFinder matches to NZ_KY270848 (Enterococcus faecalis strain 2 plasmid pGTC2, complete sequence) position: , mismatch: 7, identity: 0.794

tgggtcttttgtcaaacgtccaactaaatttact	CRISPR spacer
agggtctttggttaaacgtccaactaacgtcaca	Protospacer
 ******** **.**************  *.**

10. spacer 4.20|3729457|33|NC_006582|CRISPRCasFinder matches to NC_023560 (Oenococcus phage phiS13, complete genome) position: , mismatch: 7, identity: 0.788

gcgaggatttcaagcgggaattaaatccactgt	CRISPR spacer
gcaaggatttcaaacgggaattaagaccgttga	Protospacer
**.**********.**********. **..**

11. spacer 5.19|3739304|29|NC_006582|PILER-CR matches to NZ_CP024940 (Paraburkholderia hospita strain mHSR1 plasmid pmHSR1_P, complete sequence) position: , mismatch: 7, identity: 0.759

gattggtagtggattttatcgagcgtcta	CRISPR spacer
gtcgtgtagtcgattttatctagcgtctg	Protospacer
* .  ***** ********* *******.

12. spacer 4.13|3728991|34|NC_006582|CRISPRCasFinder matches to NZ_CP021876 (Enterococcus wangshanyuanii strain MN05 plasmid unnamed3) position: , mismatch: 8, identity: 0.765

tgggtcttttgtcaaacgtccaactaaatttact	CRISPR spacer
aggatcttttgttaaacgtccaactaatacaaca	Protospacer
 **.********.**************  . **

13. spacer 4.20|3729457|33|NC_006582|CRISPRCasFinder matches to NC_023559 (Oenococcus phage phi9805, complete genome) position: , mismatch: 8, identity: 0.758

gcgaggatttcaagcgggaattaaatccactgt	CRISPR spacer
gcaaggatttcaaacgggaattaagatcgttga	Protospacer
**.**********.**********. .*..**

14. spacer 6.2|3741138|35|NC_006582|CRISPRCasFinder,PILER-CR matches to MN855646 (Bacteriophage sp. isolate 226, complete genome) position: , mismatch: 8, identity: 0.771

acatcgatccaaaatccttcaagacttataaaagg	CRISPR spacer
caactattgcataatccttcaagacttataaaagg	Protospacer
  *... * ** ***********************

15. spacer 5.16|3740214|35|NC_006582|CRISPRCasFinder,CRT,PILER-CR matches to MH572403 (Microviridae sp. isolate SD_SF_37, complete genome) position: , mismatch: 10, identity: 0.714

tgctgcagttgagtaaatacacaatatttggggcg	CRISPR spacer
acatgcaattaagtaaatacacaatattcgattca	Protospacer
   ****.**.*****************.*.  *.

16. spacer 5.16|3740214|35|NC_006582|CRISPRCasFinder,CRT,PILER-CR matches to MH617146 (Microviridae sp. isolate ctdb64, complete genome) position: , mismatch: 10, identity: 0.714

tgctgcagttgagtaaatacacaatatttggggcg	CRISPR spacer
acatgcaattaagtaaatacacaatattcgattca	Protospacer
   ****.**.*****************.*.  *.

17. spacer 2.2|3668543|33|NC_006582|CRT,CRISPRCasFinder matches to NZ_CP020952 (Rhizobium sp. CIAT894 plasmid pRheCIAT894e, complete sequence) position: , mismatch: 11, identity: 0.667

ctcatgaaaggctcggacggcggcgatgcattt	CRISPR spacer
ggtgtgaaaggcgcggtcggcggcgatgaccgc	Protospacer
  ..******** *** ***********  . .

18. spacer 5.17|3740281|34|NC_006582|CRISPRCasFinder,CRT,PILER-CR matches to NZ_LR214939 (Mycoplasma salivarium strain NCTC10113 plasmid 2) position: , mismatch: 11, identity: 0.676

ggccatttcaagaaattgtacaaataccatgagg	CRISPR spacer
taccatttcaagaaattgttcatataaaaaagtc	Protospacer
 .***************** ** ***  * ..

19. spacer 6.4|3741272|34|NC_006582|CRISPRCasFinder,PILER-CR matches to NZ_CP048306 (Escherichia coli strain 9 plasmid p009_B, complete sequence) position: , mismatch: 11, identity: 0.676

tttggcttctgctttagtcttaaaaccgcgtttt	CRISPR spacer
aacctcttctgctttagtcttaaaattgcgcgcg	Protospacer
  .  ********************..***. .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1117517 : 1127255

Cyanophage(25.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011245881.1\|1117517_1118816_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	2.5e-17	32.4
WP_011245882.1\|1118840_1119560_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SPE1	Cyanophage	1.3e-47	43.7
WP_011245883.1\|1119552_1119804_+	phosphoribosylformylglycinamidine synthase subunit PurS	A0A1D7SRI3	Cyanophage	2.1e-05	34.6
WP_011245884.1\|1119800_1120484_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_011245885.1\|1120467_1122693_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	6.3e-162	43.1
WP_011245886.1\|1122668_1124081_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.4e-50	34.2
WP_011245887.1\|1124104_1125142_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	3.6e-67	43.6
WP_011245888.1\|1125138_1125723_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.5e-25	36.4
WP_011245889.1\|1125719_1127255_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	4.5e-74	50.7

DBSCAN-SWA_2

1403011 : 1492093

Bacillus_phage(52.5%)

protease,holin,capsid,terminase,transposase,portal,integrase,head,tail

attL 1450838:1450897|attR 1492300:1492391

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011245494.1\|1403011_1403464_+\|transposase	IS200/IS605 family transposase	A0A0H3UZM0	Geobacillus_virus	1.1e-15	32.3
WP_011246134.1\|1403975_1405442_+	catalase	A0A2K9L572	Tupanvirus	1.1e-111	51.0
WP_011246135.1\|1405727_1407488_+	M3 family oligoendopeptidase	NA	NA	NA	NA
WP_011246136.1\|1407622_1408423_+	hypothetical protein	NA	NA	NA	NA
WP_011246137.1\|1408487_1409528_-	cytochrome d ubiquinol oxidase subunit II	NA	NA	NA	NA
WP_011246138.1\|1409544_1410882_-	cytochrome ubiquinol oxidase subunit I	NA	NA	NA	NA
WP_011246139.1\|1411161_1411332_-	FbpB family small basic protein	NA	NA	NA	NA
WP_011246140.1\|1411589_1411739_+	hypothetical protein	NA	NA	NA	NA
WP_011246141.1\|1411844_1412195_+	hypothetical protein	NA	NA	NA	NA
WP_011246142.1\|1412371_1413175_+	YfkD famly protein	NA	NA	NA	NA
WP_011246143.1\|1413241_1414351_-	radical SAM/CxCxxxxC motif protein YfkAB	NA	NA	NA	NA
WP_011246144.1\|1414519_1415167_+	histidine phosphatase family protein	NA	NA	NA	NA
WP_011246145.1\|1415304_1416672_-	HlyC/CorC family transporter	NA	NA	NA	NA
WP_011246146.1\|1417079_1417901_-	DUF368 domain-containing protein	NA	NA	NA	NA
WP_011246147.1\|1418040_1418820_+	delta-lactam-biosynthetic de-N-acetylase	NA	NA	NA	NA
WP_011246148.1\|1419019_1419916_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011246149.1\|1419983_1420403_-	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_011246150.1\|1421227_1421590_-	hypothetical protein	NA	NA	NA	NA
WP_011246151.1\|1421754_1423170_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	1.0e-85	36.8
WP_011246152.1\|1423241_1424279_+	LD-carboxypeptidase	NA	NA	NA	NA
WP_011246153.1\|1424399_1424696_+	hypothetical protein	NA	NA	NA	NA
WP_011246154.1\|1424728_1425631_-	TIGR01777 family protein	NA	NA	NA	NA
WP_011246155.1\|1425732_1426554_+	recombination regulator RecX	NA	NA	NA	NA
WP_011246156.1\|1426553_1426874_+	YfhH family protein	NA	NA	NA	NA
WP_011246157.1\|1426913_1427072_-	YpzG family protein	NA	NA	NA	NA
WP_011246158.1\|1427090_1427246_-	small, acid-soluble spore protein K	NA	NA	NA	NA
WP_011246159.1\|1427358_1428339_-	metal-dependent hydrolase	NA	NA	NA	NA
WP_081427578.1\|1428461_1429595_+	A/G-specific adenine glycosylase	G3CB03	Aeropyrum_pernix_spindle-shaped_virus	7.2e-29	33.0
WP_011246161.1\|1429591_1430341_+	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	9.3e-17	32.5
WP_011246162.1\|1430374_1430725_-	hypothetical protein	NA	NA	NA	NA
WP_011246163.1\|1430740_1430941_-	hypothetical protein	NA	NA	NA	NA
WP_011246164.1\|1431046_1431796_+	enoyl-[acyl-carrier-protein] reductase FabL	NA	NA	NA	NA
WP_011246165.1\|1431863_1432016_+	gamma-type small acid-soluble spore protein	NA	NA	NA	NA
WP_011246166.1\|1432229_1432757_+	DUF402 domain-containing protein	NA	NA	NA	NA
WP_011246167.1\|1432803_1434552_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.5e-49	28.2
WP_011246168.1\|1434706_1435771_-	aromatic acid exporter family protein	NA	NA	NA	NA
WP_011246169.1\|1435861_1437166_-	glutamate-1-semialdehyde 2,1-aminomutase	NA	NA	NA	NA
WP_011246170.1\|1437333_1437804_+	thioredoxin-dependent thiol peroxidase	NA	NA	NA	NA
WP_011246171.1\|1437796_1438759_+	D-2-hydroxyacid dehydrogenase	NA	NA	NA	NA
WP_011246172.1\|1438776_1439073_+	cyclic-di-AMP receptor	NA	NA	NA	NA
WP_011246173.1\|1439281_1439713_+	peroxide-responsive transcriptional repressor PerR	NA	NA	NA	NA
WP_011246174.1\|1439783_1440149_-	YgzB family protein	NA	NA	NA	NA
WP_011246175.1\|1448267_1450652_+	phage-related pre-neck appendage protein	B7SSN3	Bacillus_phage	3.2e-143	45.9
1450838:1450897	attL	NA	NA	NA	NA
WP_011246176.1\|1451052_1452018_+\|integrase	tyrosine-type recombinase/integrase	A0A142F1N9	Bacillus_phage	5.3e-65	45.0
WP_041823703.1\|1452421_1452652_+	hypothetical protein	NA	NA	NA	NA
WP_011246177.1\|1452764_1453406_+	hypothetical protein	NA	NA	NA	NA
WP_041823706.1\|1453464_1453728_+	hypothetical protein	NA	NA	NA	NA
WP_041823709.1\|1453708_1454110_+	HNH endonuclease	A0A2H4J3B4	uncultured_Caudovirales_phage	7.4e-29	47.7
WP_011246179.1\|1454535_1455012_+\|terminase	phage terminase small subunit P27 family	A6M947	Geobacillus_virus	5.5e-23	39.7
WP_011246180.1\|1455008_1456703_+\|terminase	terminase large subunit	A6M948	Geobacillus_virus	7.1e-174	53.9
WP_011246181.1\|1456712_1456913_+	hypothetical protein	Q9ZXF9	Bacillus_phage	2.6e-11	68.5
WP_011246182.1\|1456918_1458205_+\|portal	phage portal protein	D6R3Y6	Bacillus_phage	3.1e-145	61.5
WP_011246183.1\|1458161_1458794_+\|head,protease	HK97 family phage prohead protease	Q9ZXF7	Bacillus_phage	9.1e-74	70.7
WP_011246184.1\|1458834_1460082_+\|capsid	phage major capsid protein	A0A0A7RTL2	Clostridium_phage	6.8e-89	46.3
WP_011246185.1\|1460163_1460646_+	Ig domain-containing protein	A0A1D6Z291	Staphylococcus_phage	1.9e-10	40.7
WP_011246186.1\|1460638_1460935_+\|head,tail	phage gp6-like head-tail connector protein	A0A2H4J6E5	uncultured_Caudovirales_phage	1.1e-08	43.0
WP_011246187.1\|1460927_1461266_+\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_011246188.1\|1461270_1461675_+	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_050748957.1\|1461671_1462031_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_011246190.1\|1462043_1462652_+	hypothetical protein	A0A0S2SXT6	Bacillus_phage	3.5e-22	33.2
WP_011246191.1\|1462783_1463131_+	hypothetical protein	A0A288WGA9	Bacillus_phage	2.9e-05	37.8
WP_041823712.1\|1463145_1463376_+	hypothetical protein	NA	NA	NA	NA
WP_011246192.1\|1463393_1468058_+\|tail	phage tail tape measure protein	A0A0C5AJ16	Paenibacillus_phage	2.7e-98	48.3
WP_050748958.1\|1468059_1468899_+\|tail	phage tail family protein	A6M962	Geobacillus_virus	5.5e-34	35.1
WP_011246194.1\|1468922_1471577_+	peptidase G2	D6R401	Bacillus_phage	1.3e-142	37.9
WP_011246196.1\|1473659_1474040_+	hypothetical protein	NA	NA	NA	NA
WP_152024041.1\|1474026_1474194_+	XkdX family protein	A0A142F1G4	Bacillus_phage	1.3e-11	66.7
WP_011246198.1\|1474250_1474496_+	hypothetical protein	NA	NA	NA	NA
WP_011246199.1\|1474574_1475030_-	hypothetical protein	NA	NA	NA	NA
WP_041823714.1\|1475081_1476470_+\|tail	phage tail protein	A6M966	Geobacillus_virus	3.3e-28	30.0
WP_011246201.1\|1476506_1476920_+\|holin	phage holin family protein	D6R405	Bacillus_phage	1.3e-31	53.8
WP_011246202.1\|1476922_1477828_+	N-acetylmuramoyl-L-alanine amidase	Q9ZXD7	Bacillus_phage	3.3e-45	56.1
WP_011246203.1\|1477941_1478301_+	DUF2513 domain-containing protein	NA	NA	NA	NA
WP_011246204.1\|1478537_1479053_+	hypothetical protein	NA	NA	NA	NA
WP_011246206.1\|1479424_1479811_-	YolD-like family protein	NA	NA	NA	NA
WP_011246207.1\|1479898_1480093_-	hypothetical protein	A0A2H4J069	uncultured_Caudovirales_phage	7.0e-09	60.8
WP_011246208.1\|1480490_1481267_-	hypothetical protein	NA	NA	NA	NA
WP_041823719.1\|1481416_1481869_-	ImmA/IrrE family metallo-endopeptidase	R9TQI1	Paenibacillus_phage	3.4e-38	54.2
WP_041823722.1\|1481868_1482204_-	helix-turn-helix transcriptional regulator	Q8W5Y0	Listeria_phage	1.0e-15	41.9
WP_011246211.1\|1482468_1482654_+	helix-turn-helix domain-containing protein	A0A0M3ULF9	Bacillus_phage	3.6e-15	67.2
WP_011246213.1\|1482815_1483130_+	hypothetical protein	NA	NA	NA	NA
WP_011246214.1\|1483130_1483322_+	hypothetical protein	NA	NA	NA	NA
WP_011246215.1\|1483326_1483479_+	hypothetical protein	NA	NA	NA	NA
WP_011246216.1\|1483557_1484106_+	host-nuclease inhibitor Gam family protein	Q9ZXC8	Bacillus_phage	1.8e-46	54.9
WP_011246217.1\|1484115_1485069_+	AAA family ATPase	A0A0S2SY47	Bacillus_phage	1.2e-98	58.5
WP_011246218.1\|1485084_1485522_+	DUF669 domain-containing protein	Q9ZXC5	Bacillus_phage	2.3e-39	52.4
WP_011246219.1\|1485579_1487955_+	primase	Q9ZXC4	Bacillus_phage	3.3e-294	61.9
WP_011246220.1\|1488181_1488616_+	hypothetical protein	A0A2H4J832	uncultured_Caudovirales_phage	1.5e-19	38.5
WP_011246221.1\|1488619_1489150_+	ERCC4 domain-containing protein	A0A0S2SXQ1	Bacillus_phage	3.5e-63	67.4
WP_011246222.1\|1489146_1489416_+	hypothetical protein	NA	NA	NA	NA
WP_011246223.1\|1489417_1489648_+	hypothetical protein	NA	NA	NA	NA
WP_011246224.1\|1489640_1489979_+	DUF3310 domain-containing protein	I1TLI0	Bacillus_phage	4.5e-11	51.6
WP_041823725.1\|1490092_1490488_+	hypothetical protein	NA	NA	NA	NA
WP_011246226.1\|1490526_1490715_+	hypothetical protein	A0A0A0RVG0	Bacillus_phage	7.7e-13	63.2
WP_011246227.1\|1490750_1490987_+	hypothetical protein	NA	NA	NA	NA
WP_011246228.1\|1491039_1491432_+	hypothetical protein	A0A0K2CNN3	Brevibacillus_phage	6.5e-22	48.1
WP_011246229.1\|1491434_1491635_+	hypothetical protein	NA	NA	NA	NA
WP_011246230.1\|1491652_1492093_+	transcriptional regulator	A0A0S2SXN1	Bacillus_phage	1.8e-28	46.2
1492300:1492391	attR	NA	NA	NA	NA

DBSCAN-SWA_3

2912943 : 2973274

Bacillus_phage(48.15%)

holin,terminase,transposase,tRNA,capsid,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011247620.1\|2912943_2913585_-\|tRNA	tRNA (guanosine(46)-N7)-methyltransferase TrmB	NA	NA	NA	NA
WP_011247621.1\|2913680_2913929_+	hypothetical protein	NA	NA	NA	NA
WP_011247622.1\|2913987_2914782_-	phosphotransferase family protein	NA	NA	NA	NA
WP_011247623.1\|2915244_2916108_+	formyltetrahydrofolate deformylase	M4QRX9	Synechococcus_phage	9.1e-16	35.3
WP_011247624.1\|2916148_2916877_-	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	1.5e-16	32.0
WP_011247625.1\|2916933_2917248_-	hypothetical protein	NA	NA	NA	NA
WP_011247626.1\|2917631_2918864_-	2-oxo acid dehydrogenase subunit E2	NA	NA	NA	NA
WP_011247627.1\|2918893_2919937_-	alpha-ketoacid dehydrogenase subunit beta	NA	NA	NA	NA
WP_011247628.1\|2919954_2920902_-	thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha	NA	NA	NA	NA
WP_041823927.1\|2920929_2922282_-	dihydrolipoyl dehydrogenase	NA	NA	NA	NA
WP_011247630.1\|2922549_2924493_-	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_011247631.1\|2924715_2925420_-	LrgB family protein	NA	NA	NA	NA
WP_011247632.1\|2925385_2925790_-\|holin	CidA/LrgA family holin-like protein	NA	NA	NA	NA
WP_011247633.1\|2925786_2926347_-	RNA 2',3'-cyclic phosphodiesterase	NA	NA	NA	NA
WP_011247634.1\|2926430_2927363_+	cysteine synthase A	A0A1W6JIM2	Lactococcus_phage	2.8e-79	55.3
WP_011247635.1\|2927530_2928409_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_035201960.1\|2928562_2928919_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_035201965.1\|2928932_2929754_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_011247638.1\|2930046_2930487_-	metallothiol transferase FosB	Q2LI91	Bacillus_phage	1.7e-23	46.5
WP_011247639.1\|2930779_2930998_+	DeoR/GlpR transcriptional regulator	NA	NA	NA	NA
WP_011247640.1\|2931029_2931761_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_011247641.1\|2931806_2932967_-	rod shape-determining protein RodA	NA	NA	NA	NA
WP_011247642.1\|2932980_2934123_-	putative lipid II flippase FtsW	NA	NA	NA	NA
WP_011247643.1\|2934459_2936061_-	polysaccharide biosynthesis protein	NA	NA	NA	NA
WP_011247644.1\|2936256_2937114_-	SMP-30/gluconolactonase/LRE family protein	NA	NA	NA	NA
WP_011247645.1\|2937110_2937518_-	YjbQ family protein	NA	NA	NA	NA
WP_035201976.1\|2937773_2938955_-	amidohydrolase	NA	NA	NA	NA
WP_011247647.1\|2939090_2939675_+	aminoacetone oxidase family FAD-binding enzyme	NA	NA	NA	NA
WP_160162517.1\|2939662_2939827_-	hypothetical protein	NA	NA	NA	NA
WP_011247648.1\|2940122_2941262_-	hypothetical protein	NA	NA	NA	NA
WP_099045556.1\|2942009_2942180_+	hypothetical protein	A0A2H4J069	uncultured_Caudovirales_phage	1.2e-09	68.8
WP_152024047.1\|2942281_2942662_+	YolD-like family protein	NA	NA	NA	NA
WP_011247651.1\|2942718_2943552_+	ATP-dependent DNA ligase	O64130	Bacillus_phage	1.6e-62	46.5
WP_011247652.1\|2943959_2944262_+	hypothetical protein	NA	NA	NA	NA
WP_152024048.1\|2944254_2944728_+	type I-C CRISPR-associated protein Cas8c/Csd1	NA	NA	NA	NA
WP_011247654.1\|2944873_2945146_+	hypothetical protein	NA	NA	NA	NA
WP_011247655.1\|2945479_2946676_-\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	2.1e-23	24.7
WP_011247656.1\|2946956_2947301_+	hypothetical protein	NA	NA	NA	NA
WP_011247657.1\|2947329_2948346_-	N-acetylmuramoyl-L-alanine amidase	D6QWM8	uncultured_phage	6.2e-48	55.2
WP_011247658.1\|2948345_2948573_-\|holin	holin protein of PBSX prophage	NA	NA	NA	NA
WP_011247659.1\|2948562_2948853_-	hypothetical protein	D2XR31	Bacillus_phage	6.1e-25	65.9
WP_011247660.1\|2948889_2950275_-\|tail	phage tail protein	A6M966	Geobacillus_virus	4.3e-36	29.8
WP_011247661.1\|2950261_2950441_-	XkdX family protein	A0A142F1G4	Bacillus_phage	2.1e-12	64.0
WP_011247662.1\|2950437_2950806_-	hypothetical protein	NA	NA	NA	NA
WP_081427718.1\|2950816_2952727_-	hypothetical protein	W8CZP9	Erwinia_phage	5.3e-16	28.2
WP_011247664.1\|2952752_2955404_-	peptidase G2	D6R401	Bacillus_phage	5.2e-147	37.8
WP_011247665.1\|2955414_2956236_-\|tail	phage tail family protein	A6M962	Geobacillus_virus	2.2e-56	43.5
WP_050748987.1\|2956232_2962001_-	peptidoglycan DD-metalloendopeptidase family protein	A0A2H4JA91	uncultured_Caudovirales_phage	1.1e-93	29.9
WP_011247667.1\|2962052_2962874_-	hypothetical protein	NA	NA	NA	NA
WP_041823937.1\|2962927_2963137_-	hypothetical protein	NA	NA	NA	NA
WP_011247669.1\|2963274_2963757_-	hypothetical protein	A0A218KCI2	Bacillus_phage	1.3e-16	37.6
WP_011247670.1\|2963802_2964201_-	hypothetical protein	NA	NA	NA	NA
WP_011247671.1\|2964266_2964854_-	hypothetical protein	A0A2H4J7F5	uncultured_Caudovirales_phage	7.2e-33	43.3
WP_011247672.1\|2964840_2965266_-	hypothetical protein	M4ZR34	Bacillus_phage	7.1e-14	32.1
WP_011247673.1\|2965262_2965745_-	hypothetical protein	M4ZRN5	Bacillus_phage	4.5e-33	48.4
WP_152024049.1\|2965737_2966076_-	hypothetical protein	NA	NA	NA	NA
WP_011247675.1\|2966075_2966408_-	hypothetical protein	A0A1U9WQS7	Geobacillus_phage	6.8e-20	47.7
WP_041823940.1\|2966409_2966625_-	hypothetical protein	NA	NA	NA	NA
WP_011247676.1\|2966635_2967652_-\|capsid	major capsid protein	A0A142F1M0	Bacillus_phage	8.9e-71	42.4
WP_011247677.1\|2967693_2968083_-	hypothetical protein	A0A142F1L9	Bacillus_phage	5.3e-32	54.6
WP_041823943.1\|2968086_2968758_-	hypothetical protein	M4ZSA3	Bacillus_phage	2.8e-12	30.0
WP_011247679.1\|2968851_2969952_-	hypothetical protein	M4ZR27	Bacillus_phage	4.4e-84	43.7
WP_011247680.1\|2969948_2971556_-	hypothetical protein	A0A1U9WQP5	Geobacillus_phage	2.8e-159	56.8
WP_041824688.1\|2971566_2972856_-\|terminase	PBSX family phage terminase large subunit	A0A1B1UZZ1	Enterococcus_phage	8.9e-185	73.4
WP_011247682.1\|2972836_2973274_-\|terminase	terminase small subunit	S5MA50	Brevibacillus_phage	1.6e-40	60.7

DBSCAN-SWA_4

2977112 : 2987986

Bacillus_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011247687.1\|2977112_2977553_-	hypothetical protein	A0A0U3TGS2	Bacillus_phage	5.6e-38	56.4
WP_160162518.1\|2977539_2977710_-	hypothetical protein	NA	NA	NA	NA
WP_011247688.1\|2977721_2978216_-	RusA family crossover junction endodeoxyribonuclease	S6B1L9	Thermus_phage	4.4e-31	50.4
WP_160162519.1\|2978199_2978337_-	hypothetical protein	NA	NA	NA	NA
WP_011247689.1\|2978505_2979015_-	dUTP diphosphatase	D2XR49	Bacillus_phage	1.0e-35	48.8
WP_050748989.1\|2979029_2979269_-	hypothetical protein	NA	NA	NA	NA
WP_041823955.1\|2979278_2979536_-	hypothetical protein	NA	NA	NA	NA
WP_011247690.1\|2979545_2979968_-	single-stranded DNA-binding protein	A0A1X9IGF2	Lactococcus_phage	1.4e-22	44.7
WP_041823958.1\|2979968_2980148_-	hypothetical protein	NA	NA	NA	NA
WP_011247691.1\|2980141_2981002_-	DNA (cytosine-5-)-methyltransferase	A8YQM6	Lactobacillus_phage	6.1e-73	52.0
WP_011247692.1\|2981141_2981603_-	HNH endonuclease	A6M989	Geobacillus_virus	4.2e-36	56.8
WP_011247693.1\|2981605_2982268_-	sigma-70 family RNA polymerase sigma factor	G3MBD9	Bacillus_virus	1.3e-06	27.5
WP_011247694.1\|2982264_2982537_-	hypothetical protein	NA	NA	NA	NA
WP_041823961.1\|2982512_2982797_-	hypothetical protein	NA	NA	NA	NA
WP_011247695.1\|2982800_2983637_-	ATP-binding protein	A0A1B1P8D0	Bacillus_phage	1.3e-64	48.6
WP_011247696.1\|2983569_2984349_-	conserved phage C-terminal domain-containing protein	A6M985	Geobacillus_virus	1.3e-50	68.9
WP_011247697.1\|2984515_2985238_-	phage antirepressor KilAC domain-containing protein	G4KNN1	Staphylococcus_phage	2.3e-73	55.2
WP_011247698.1\|2985393_2985633_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011247699.1\|2985808_2986036_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011247700.1\|2986215_2986551_-	hypothetical protein	NA	NA	NA	NA
WP_160162520.1\|2986831_2987002_-	hypothetical protein	NA	NA	NA	NA
WP_011247701.1\|2987033_2987375_-	hypothetical protein	A8ASP1	Listeria_phage	6.3e-05	39.7
WP_160162521.1\|2987371_2987638_-	hypothetical protein	NA	NA	NA	NA
WP_160162522.1\|2987628_2987793_-	hypothetical protein	NA	NA	NA	NA
WP_041823964.1\|2987797_2987986_-	hypothetical protein	A0A2D1GQ75	Lysinibacillus_phage	4.1e-06	43.1

DBSCAN-SWA_5

3234367 : 3243113

Bacillus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_035202795.1\|3234367_3236470_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	U5PY35	Bacillus_phage	0.0e+00	79.6
WP_011247951.1\|3236506_3237511_+	class 1b ribonucleoside-diphosphate reductase subunit beta	R4JMU8	Bacillus_phage	7.3e-150	80.1
WP_011247952.1\|3237698_3238325_+	hypothetical protein	A0A127AYS1	Bacillus_phage	1.1e-44	42.0
WP_011247953.1\|3238371_3238917_-	cysteine hydrolase	G3MA16	Bacillus_virus	5.3e-30	41.1
WP_011247954.1\|3239037_3239244_+	hypothetical protein	NA	NA	NA	NA
WP_011247955.1\|3239323_3240616_+	glycoside hydrolase family 18 protein	NA	NA	NA	NA
WP_011247956.1\|3240742_3241498_+	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	7.4e-14	28.8
WP_011247957.1\|3241622_3243113_-	sucrose-6-phosphate hydrolase	F8WPR5	Bacillus_phage	9.8e-34	28.5

Anti-CRISPR protein detection

Acr_ID: NC_006582.1|WP_160162522.1|2987628_2987793_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_006582.1|WP_160162522.1|2987628_2987793_-|hypothetical-protein

2987628_2987793_-

54 aa aa

2977112-2987986

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_006582_4	TypeI	4.14\|3729057\|35\|NC_006582\|CRISPRCasFinder	3729057-3729091	35	2981070-2981036	0
NC_006582_5	TypeI	5.17\|3740281\|34\|NC_006582\|CRISPRCasFinder,CRT,PILER-CR	3740281-3740314	34	2977394-2977361	0

1. spacer 4.14|3729057|35|NC_006582|CRISPRCasFinder matches to NC_006582 position: 2981070-2981036, mismatch: 0

gatttagaacgcgaaaaggtgccggggcgggtaag	CRISPR spacer
gatttagaacgcgaaaaggtgccggggcgggtaag	Protospacer
***********************************

2. spacer 5.17|3740281|34|NC_006582|CRISPRCasFinder,CRT,PILER-CR matches to NC_006582 position: 2977394-2977361, mismatch: 0

ggccatttcaagaaattgtacaaataccatgagg	CRISPR spacer
ggccatttcaagaaattgtacaaataccatgagg	Protospacer
**********************************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_006582

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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