CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Prophage number
NC_012490	Rhodococcus erythropolis PR4, complete genome	5 crisprs	WYL,cas3,csa3,cas4,DEDDh,DinG,Cas9_archaeal,RT	4
NC_007487	Rhodococcus erythropolis PR4 plasmid pREC2, complete sequence	0 crisprs	NA	0
NC_007491	Rhodococcus erythropolis PR4 plasmid pREL1, complete sequence	0 crisprs	csf1gr8,csf4gr11,csf2gr7,csf3gr5,csa3,PD-DExK	2
NC_007486	Rhodococcus erythropolis PR4 plasmid pREC1, complete sequence	0 crisprs	NA	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_012490_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012490_1

128133-128249

Orphan

Consensus_repeat	Method
GAAGCTGAACGGGTTGTCGACGAGGGCGTTGGTGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012490_1

>merge|NC_012490|1|128133-128249|CRISPRCasFinder
GAAGCTGAACGGGTTGTCGACGAGGGCGTTGGTGCCCACACCCTGCAGAGCGTGTGCGGACGTCGCCTCGGCAACCGGCTCGAAGGTGAACGGGTTGTCGACGAGGGCGTTGGTGCC

>NC_012490|1|1|128133-128249|CRISPRCasFinder
GAAGCTGAACGGGTTGTCGACGAGGGCGTTGGTGCC	CACACCCTGCAGAGCGTGTGCGGACGTCGCCTCGGCAACCGGCTC
GAAGGTGAACGGGTTGTCGACGAGGGCGTTGGTGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012490.1\|WP_020905683.1\|119232_120279_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650
NC_012490.1\|WP_020905697.1\|134022_135669_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340879
NC_012490.1\|WP_020905682.1\|117915_119118_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_012490.1\|WP_020905693.1\|130812_131607_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NC_012490.1\|WP_020905687.1\|123170_124463_-\|YcaO-like-family-protein	unknown	unknown	gnl\|CDD\|274674
NC_012490.1\|WP_019746312.1\|129748_130816_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_012490.1\|WP_019746321.1\|137003_137591_+\|DinB-family-protein	unknown	unknown	gnl\|CDD\|368218
NC_012490.1\|WP_020905695.1\|132588_133275_+\|SagB-family-peptide-dehydrogenase	unknown	unknown	gnl\|CDD\|188352
NC_012490.1\|WP_020905696.1\|133566_134019_-\|hypothetical-protein	unknown	unknown	unknown
NC_012490.1\|WP_003943598.1\|121127_121568_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|379177
NC_012490.1\|WP_019746303.1\|121574_122201_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_012490.1\|WP_020905694.1\|131603_132584_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238568
NC_012490.1\|WP_041814452.1\|135737_136985_-\|hypothetical-protein	unknown	unknown	unknown
NC_012490.1\|WP_020905689.1\|125792_127220_-\|CocE/NonD-family-hydrolase	unknown	unknown	gnl\|CDD\|225487
NC_012490.1\|WP_020905684.1\|120275_121016_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_012490.1\|WP_019746316.1\|133276_133570_-\|SHOCT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378276
NC_012490.1\|WP_041814446.1\|127216_128029_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274832
NC_012490.1\|WP_041814449.1\|128404_129664_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_012490.1\|WP_020905688.1\|124459_125800_-\|YcaO-like-family-protein	unknown	unknown	gnl\|CDD\|274674
NC_012490.1\|WP_020905686.1\|122252_123224_+\|sugar-nucleotide-binding-protein	unknown	unknown	gnl\|CDD\|224662

Protein	Function_ID	Function_description	E-value
NC_012490.1\|WP_020905683.1\|119232_120279_+\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	4.05536e-11
NC_012490.1\|WP_020905697.1\|134022_135669_-\|MFS-transporter	gnl\|CDD\|340879	cd17321, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.57525e-22
NC_012490.1\|WP_020905682.1\|117915_119118_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	7.76978e-52
NC_012490.1\|WP_020905693.1\|130812_131607_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.1474e-103
NC_012490.1\|WP_020905687.1\|123170_124463_-\|YcaO-like-family-protein	gnl\|CDD\|274674	TIGR03604, hypothetical_protein, thiazole/oxazole-forming peptide maturase, SagD family component. Members of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins.	1.73404e-69
NC_012490.1\|WP_019746312.1\|129748_130816_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	6.26105e-91
NC_012490.1\|WP_019746321.1\|137003_137591_+\|DinB-family-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	9.98775e-42
NC_012490.1\|WP_020905695.1\|132588_133275_+\|SagB-family-peptide-dehydrogenase	gnl\|CDD\|188352	TIGR03605, antibiot_sagB, SagB-type dehydrogenase domain. SagB of Sterptococcus pyogenes participates in the maturation of streptolysin S from a ribosomally produced precursor polypeptide. Chemically similar systems operate on highly diverse sets of bacteriocin precursors in numerous other bacteria. This model describes a domain within SgaB and homologous regions from other proteins, many of which appear to be involved in biosynthesis of secondary metabolites. While some substrates may be intermediates in non-ribosomal peptide syntheses, others are involved in heterocycle-containing bacteriocin biosynthesis, and can be found near SgaC-like (see TIGR03603, cyclodehydratase) and SgaD-like (see TIGR03604, "docking") proteins. Members of this domain family are heterogeneous in length, as many have a partial second copy of the domain represented here. The incomplete second domain scores below the cutoffs to this model in most cases.	1.44815e-25
NC_012490.1\|WP_003943598.1\|121127_121568_+\|PAS-domain-containing-protein	gnl\|CDD\|379177	pfam13426, PAS_9, PAS domain.	3.26675e-11
NC_012490.1\|WP_019746303.1\|121574_122201_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.36454e-09
NC_012490.1\|WP_020905694.1\|131603_132584_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238568	cd01148, TroA_a, Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.	1.36218e-44
NC_012490.1\|WP_020905689.1\|125792_127220_-\|CocE/NonD-family-hydrolase	gnl\|CDD\|225487	COG2936, COG2936, Predicted acyl esterases [General function prediction only].	2.80212e-36
NC_012490.1\|WP_020905684.1\|120275_121016_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.05621e-79
NC_012490.1\|WP_019746316.1\|133276_133570_-\|SHOCT-domain-containing-protein	gnl\|CDD\|378276	pfam09851, SHOCT, Short C-terminal domain.	2.65717e-06
NC_012490.1\|WP_041814446.1\|127216_128029_-\|hypothetical-protein	gnl\|CDD\|274832	TIGR03882, hypothetical_protein, bacteriocin biosynthesis cyclodehydratase domain. This model describes a ThiF-like domain of a fusion protein found in clusters associated with the production of TOMMs (thiazole/oxazole-modified microcins), small bacteriocins with characteristic heterocycle modifications. This domain is presumed to act as a cyclodehydratase, as do members of the SagC family modeled by TIGR03603.	0.000120436
NC_012490.1\|WP_041814449.1\|128404_129664_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.89897e-54
NC_012490.1\|WP_020905688.1\|124459_125800_-\|YcaO-like-family-protein	gnl\|CDD\|274674	TIGR03604, hypothetical_protein, thiazole/oxazole-forming peptide maturase, SagD family component. Members of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins.	1.80926e-69
NC_012490.1\|WP_020905686.1\|122252_123224_+\|sugar-nucleotide-binding-protein	gnl\|CDD\|224662	COG1748, LYS9, Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism].	2.25791e-11

>NC_012490.1|WP_041814446.1|127216_128029_-|hypothetical-protein
MYALADGHHPYPTPDGVWHYLTPDENAVTIGAPAEDLAELDNFLRRSGSVLGPGAIEIADALVSRGVLAVPGQVPEIPAPQRVLMDGVGPVADACIALLSKALPDLEVVSTTAPIEDDVASSDLVLSVADAPPHDAWSELDTWCRHSRTPWQRVHKELGEICIGPFFDGIDSASYRDVCGRRLAASRVPDHLLALWNHLADSERRPLGLSPTAAAMVSALACSDVVAGAHGAPQSHLHHQIRMNPRTLMMTRHPVLPLPGGVLEPSPTLR
>NC_012490.1|WP_020905689.1|125792_127220_-|CocE/NonD-family-hydrolase
MISLGVKIPAADGSSLATDVLLPDSSPRGLIVIRTPYGRGWHLAEGLEWRSRGIAFICQDVRGRHDSTGSWEPYVHERLDAAALAEWLQDQPWTPECVIASGASYAAGTAWAFAAETNNADRAFRARGIVSKVPTIGSDRVKRDPSGILLLAEHLAWWGEHGDSSSSREGFIPALMRSDSSLLEHLPVQSMIEEVGLTSDSPGWLTPILRAREREPYGSDDLVSADELSELDVAVLHIGGWDDAMIQETLRHFTSVGRGPQSLIVGPWAHDLRPGMVGETSFGRLQVEWMESIFSARPVTINRVFDRGAGDWSSEPYVTGANRVRLEPDPRTAPFNFTHHADEGRNDCVVWTFDMEVECVLSGMPSVELTVHSPEGEADWIVELSVVDPAGVTRSIARGAGVSLQPTMVTIDLDPVLHTVRAGDVLTLRIAGSDFPRLARNLGDGDRYRGTRSTALHQSFSGSLTLPMLGGTAGG
>NC_012490.1|WP_020905688.1|124459_125800_-|YcaO-like-family-protein
MDELLVDARSGVLTSLEPHIRSDMPTGWVGWSARVADTRNFGGSGSLFRADPYGFGASIRDDAAARGAATGEAVERYCGNVVPEDLIRSSASALELAGSRVVDPAKFALYSEDQYRLPGFPFVPFTSALEIRWALGHTMDEKVPTYVPAALTYLGYYTGTRRGEPPIASLQYAGIAAGRSRDEAEMSALLELLERDATALWWCGDRSQPAIELADWERLPAHRQLGDLESQTRSVRVLLLPSPFGIPVAAVWIRDDRRGLVALGTACRPTVEAAVSKALVEAYAVLAITIDLADPDGPTWRSVADGTLPAHLYKPFRADRRYRDEFDAQWKDVVDLPTVAQLYLDPVMAHLAEEHLFDYTETRSVSEVPDEDPVNLASLVALLTSRGYQPISVDLTTRDISIAGLHVVRVLSPGLYNNAPAAFPLLGGSRVTSASTTHLHLPVPLA
>NC_012490.1|WP_020905687.1|123170_124463_-|YcaO-like-family-protein
MRSLLVDRRTGIIRELVDAFVPQHFPPEFKLIHSYASDSARFSPWSSDSAGAGYCFDLGDRARPTAAAIGEAVERYCGNIVAKPIVRGSADALIGASIDLSQLARFDAAQYAQPQFPFVEPTDDLELDWTRGVDLITGADTWVPAELVWGSYPHFVARTGPAISPVAQAGLAAGPTTEFAIRNALREIVERDAMTLSWTGRRGVRIVTGIPEVLRRLGNHGSLSTRWLSFDSDFGIPVLGALVHDRLTGYSTMGTACHEEARTAAFKSLGEALQLQLLSADYDNPESGIGRAAASPTSPLAPWRADRSYAGAYRSDFADVMDYGCHLQLHLDPEIQARFESELAGAVVGEVDLDSLTSPIDTESALTGSGFRPAWVDLTTTDVLSAGLRVVRVVVPGCLTNAAAGLPFLGSPRLVDGLAGRPPRTIPLPH
>NC_012490.1|WP_020905686.1|122252_123224_+|sugar-nucleotide-binding-protein
MTKVLVLGGYGAVGIPLMKQLAKVPEISAYSAGRDRARADVVVDLKEPGAYSAAVRDFDVVVNASGFEDVRLAEEAVRGGAAFVDITATSNYCEELEAVDGPVLMGVGLAPGLTSVLAAEAHRLGDGPVDIVIGLGGGELHGPAATAWTYGMLGTRFPDPDGRSIRNYTGMKTFRMPADATGYRSGPAVRADFSDQHALTRDLGVPVRTYLRLDTSTATLGLAAMTWAPALQKVVPKKLWGSDRWVAMARTDTGPALWVSGRSQSAATATIAARAVQVIRDSAISKPTWFHAVETAESLQLAVPELSVRQWDGTRRTSGKAVD
>NC_012490.1|WP_019746303.1|121574_122201_-|TetR/AcrR-family-transcriptional-regulator
MTEVLREDTSARRKIIEAAREVFVDPGYAAATIKQLAAAAGVSVQSVYFVFGNKPSVLSALLDVAVAGDEEKTATLDRPWVAAALGAPHPLGQLRIQVHHGRLILERTADILLALRAAASADEDAARLWQINRTQRRTVQEHLMVGIVEKAPTVDLETAVNVALTLLSPETYTDLVVGAGWTGQKYEEWVVNTLAATLGLDRTVKSRK
>NC_012490.1|WP_003943598.1|121127_121568_+|PAS-domain-containing-protein
MERRRNVAQPPQSPIADLEQMPALILLDRLPVPVMAVHRDGSIVFANPSFADMLGYPKKAVSALRLQDILYDKDADDVSAEQAHRELSSEPGSVKEFVHSDSTLVRATVSQSLLRRDDDTITLAVLHDLTERLWNNPRHIDDKPTK
>NC_012490.1|WP_020905684.1|120275_121016_+|ABC-transporter-ATP-binding-protein
MTVTTGTTVLDIQNVDLTFPDGQSRVTALDDVSLRLHRGEIAAITGPSGSGKSSLLAVASTLIRPDSGHVYLRTPEGSTDIAALSRRAASELRRSSIGIVFQQSNLVSSLTALEQLEVMAHLGQSVFTSRTRRKAVKSKAMDLLDAVGLADQSGKRPSQLSGGQRQRVNLARALMNDPQLLVVDEPTSALDQERGAAVMDLIIGVVREHEAATLLVTHDRSHLSRMDTVYRVVDGSLAEDQEALAA
>NC_012490.1|WP_020905683.1|119232_120279_+|ABC-transporter-permease
MFVAMRDLRAARGRFALISVVVLLVALLVSFLSGLTAGLRHQNVSAIEAMNADTVVFADTGAGASFDESALTQDQVNAWAGAAKDVDPIGIGRGKAGLADGNQKSVALFGADGGFGDVTPSASGTVVLSEGAARDLGAGAGDQVSVGTQQFTVSDVRGDDWYSHSPVVWMTLGDWQAANPRGGVATVLAVTGASDASATDKSAVTTSTTVSGSLDAIGSYKSENGSLTLMTLMLFAISALVIGAFFTVWTIQRTPDIATLKALGATTGSLVRDALGQALIVLIAGVTAGIGLTAVAGSLIGDAMPFVLDASTTVVPAVALIGLGLLGAAFALRFLSTTDPLTALGSAR
>NC_012490.1|WP_020905682.1|117915_119118_-|sensor-histidine-kinase
MDEPGPNLAKLGEMHRSPLTPVFAGLQLGLHVLVMALAGVVFLRALIDESDLTATIIALAVIFVAVYLFGVAKRLRGNAARWWLAVLTLVWIATMAVSADAAYLAFGLFFLYLHILRRPWSLLAVTAATAVAVIGTGLHRGWTVAGAVGPIIGAAVAVAIGLGYQALYREAAERGRLIDELMNTREELASTSRDAGKFAERERLAAEIHDTVAQGLSSIQMLLHAAERADPESPAIRQISLARETAADSLAETRQLIAELTPAALDGQSLADALRRICERASSPELEARSVVEGEALRLPMPLEATLVRIAQGAVSNVLRHADATRMAVTLTYSDNTVSLDVVDNGRGFDVAVLERGPAESFGLNAIRRRVELQGGTFSIESEPGHTAVAVTFPLDVGEQ
>NC_012490.1|WP_041814449.1|128404_129664_+|MFS-transporter
MSETSTTGSAEAQPHVFRDRSFRLFFTARTIAVAGAAVTGVAMPILVFDISRSPFLTSLAAAGTVLPYLVFGLFAGAVADRVNRRTVILCAQAVAALALASIPAAQALGVLTAWHAVGVSMCIGTCFVWFDAAAFGALPALVGRQRIPAANSALWTSSTLVDVAFPAIAGVLVASIGPAYALGADALAYVLAGLAMASIGASFSSTPAVPKKSEPGIARDIREGLSFLWQSPLLRALTGVGFVNSLTQGAVTALLVVYATEGLGISTSSPMIGAVWTAVSVGGVVGAVLLPRLPAQWPVGAITVGALTIAPVVLFVVATTSNTAAAITALTVYSGCATVTILNGIGARQRLTPDRLQGRVNTTARMVAWGGSPVGALIAGAIAGRWDIGTAYLVACSFALVGALFAWVSALRTDPCPHR
>NC_012490.1|WP_019746312.1|129748_130816_+|iron-ABC-transporter-permease
MTLTSEAVPDAPSRAHPVGDRGYVPFLLATAVVLATVSTVAVWSGAASLSFADVFAVLYAHVGGPPVDPLLDRIVWGLRVPRILIAALAGAGLSLAGAVLQALVRNPIADPYILGVGSGASFGAVLIMTTGIGTGLSIGVPVAAFLGAMVSLIAVLVLGRREGMLVPLRMVLAGVAIGYLLSAATSFVQLRADPSQLSGVLFWLLGSVSGAGWSDLGVPAAVITVCAAVLLTQSRQLNALAMGDESAQSVGVDVRRTRLLLLVIASLLTAVVVSVAGGIGFVGLLVPHAVRLLVGSDHRKLLPATALVGATFLVIVDLAARMLDAPNELPLGIITAGLGAPFFLWLLRRDGGAQS
>NC_012490.1|WP_020905693.1|130812_131607_+|ABC-transporter-ATP-binding-protein
MRLSASGIHVVRGGRLVVSGVNLEAPEGSVVGLVGPNGSGKSSLLRALYRSMKPRSGIVKVDEVNVWDDLSPRSAARIIGVVGQEHSSDFSFSVREVVATGRTPHHSAFSRLGEIDRDIVSAALARTGMHGFGSRLFAELSGGEKQRVMLARAIAQQPSVLVLDEPTNHLDIRAQLELMELVAELGTTTIVAIHELALAAAYCDYVCLLSGGVVVATGPTAEVLTEDLLSEVFGVQVHLGTHPLTGRPLLSFAPPLLHTKEAVS
>NC_012490.1|WP_020905694.1|131603_132584_+|ABC-transporter-substrate-binding-protein
MKSSIRTAALLCSAVTATAVLTACGNSTADSAASSSEKISVTNCDREVTLPKTAERIVSLYPSMTELLIQLGAADRIVGQSNTDLSPPSPELADQFAEVPVLSTGVPAKEALLDARPDLIVSDGEYWFDGDRLQTMDELRDLGIPIFVNSGYCHKAVTEGRIDDVWSDLDGLGALTGTSDAAATLLADGKKSLAATEASVAGQEPVPAVMVQVSEGQSYALARGLYSSVLEAAGGSNLFENDLPDGKYFGQVATESVLAKSPKAVLVVYSTESARESTLDAARTAFAGTPAATSNAIFAVPEAWFAGELVSIDGAAEVSRLLHPGS
>NC_012490.1|WP_020905695.1|132588_133275_+|SagB-family-peptide-dehydrogenase
MTALERVEAVVSLHAALDRTVAPSELLFDEAALPPVTPEFVELPAPTPLPARDFPDILQARRSHYNPAQVALGIGELSNVLHHSLVSSPTAGGMRELTLSFVVSHPGHSLGAGVYRYIQEGRAEAVRPGDVQGNLRASLLQPEFVDVFPVLLFVVADVEAPLEKYAMRHYRTMHVDAGVLVQNLYLVTEAMGLVGCAIAGFTDARVASLLNLATTQLPVMAFALGRPS
>NC_012490.1|WP_019746316.1|133276_133570_-|SHOCT-domain-containing-protein
MSFLRRAGRVAVASSIHGNVQRRQRTRWAAEDQARAAQVQPVPPIPDLPPLPPQAAPAESEMSMDAKLEQLTKLGELKNAGVLTEAEFETQKARILG
>NC_012490.1|WP_020905696.1|133566_134019_-|hypothetical-protein
MSNQDQFGPIEYVAVEFPGSAPTSAGFEQLLALVDSGVIRILDLEFVTKAADGSVSVVPASTFELVDFDLAQFDGAASGLLDVGDIAAVGEELAAGSVAAVLVYEELAILPVIEAWTRSGAKVVTEGHLSLDELAAALDNTAPDTTEKDA
>NC_012490.1|WP_020905697.1|134022_135669_-|MFS-transporter
MSVKPGAADTSAAVTTASWLPLIVVVLTQIQASFAVNALTVSMAGITTDLDTPATSVGTAITAGTFAMAAFILLGAKIGARYGTRLVFQIAVAIHGLAMAAVALSQSPAMLFVAQAASGAVIALIAPALTVFIATNFSGDQQAKAIGYLAAAIPAAGVLALLIAGSFATTIGWRYSFALVVALAVVNLVLSFRVKPVPPQKDITIDWAGAAIAAVAVILLSFGFSGLNSWGVILATDAAPFSVIGVSPAAILIVLGTICAQGFFQWTRSRKAQNKPQLFNLDVLKTGAERATTICMATMMFVGTAANFLIPLYMQIIQGRSSLQTSFSIIPYTLSIFIASTVVARLYKTYSPRLIARAGFVVVAAGLILLAFTIRGDWHQIFVVIGLITLGLGQGAIVALVFNTLLTAAPKELAGDVGAWRGLVHNMSGSVGIAVASVFAVGILGTLVSSQLIDNPTIPASLKVESGINLDQVNFVPNDQLVVTLENTSATQAQIDEAIRINTEARLRALRTSLLVLAGLSLLAIIPAGRMPNEVPALEEPQPTKGKK
>NC_012490.1|WP_041814452.1|135737_136985_-|hypothetical-protein
MEQTLTAVEDLTEVASRAVAAERDARSVRWHNPAAVRKAAASVRDSLDDERSALSRPSYSGLSPSPHMARQLELITTLQPPLPADAGISTAAQAEADAVAAVTTARIALRAAHLAVLEARVAALDAGDTDTVAAAIRGYVPLNSGNPVVRHVQDLGSRIREEARHVVSGKPRSIAFRLGLSLGMGLAYLAFIRLFQWDAKEDRLPYLALYALSGVVGSVVCTNALSFDAGRVRAALSGGTRLWHVLVAKNAMMLLLVGSAGFLLSAILAWRSGSSADLVKACGQVLTMILLWLGVANVMSVALPLRAEPMTARRHDGTWKQFLLSFVISYGVGLIVNLMLYWRVWAKTTLLEQMGGPWIPVLLLLASAAATWLLLTVLAVLLAEQPRFRRGLQREMVVYREKTNHPQATIQHNSG
>NC_012490.1|WP_019746321.1|137003_137591_+|DinB-family-protein
MTTNSEKEDLQRYLQAARDALVWKLDGLSEYDIRRPMTRTGTNLLGLVKHMIGVELGYFGPTFGRRVPDLPAWLRSEELNVDMWARADESSADIVETYRRTWAFADATIEQHDLDAPGFVKHWPEDRRDVTLHRILVHVVTEIHRHAGHADIVRELIDGAAGMKAGDNNLAPGDEAWWAEYNDRLETAAREAHHA

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Crispr_ID: NC_012490_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012490_2

2313611-2313696

Orphan

Consensus_repeat	Method
CACCGGATGCTGCGCCGCCGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012490_2

>merge|NC_012490|2|2313611-2313696|CRISPRCasFinder
CACCGGATGCTGCGCCGCCGCCGGCGCCGCCGCGCTTGCGTGCCTTCGGCTTCTTGCGGATGGCACCGGATGCTGCGCCGCCGCCG

>NC_012490|2|2|2313611-2313696|CRISPRCasFinder
CACCGGATGCTGCGCCGCCGCCG	GCGCCGCCGCGCTTGCGTGCCTTCGGCTTCTTGCGGATGG
CACCGGATGCTGCGCCGCCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012490.1\|WP_020907075.1\|2315336_2316737_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|334202
NC_012490.1\|WP_020907073.1\|2312190_2312553_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227939
NC_012490.1\|WP_020907078.1\|2321285_2322983_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_012490.1\|WP_019747751.1\|2325132_2325474_-\|acyl-CoA-carboxylase-subunit-epsilon	unknown	unknown	gnl\|CDD\|379386
NC_012490.1\|WP_020907070.1\|2310428_2310758_-\|hydroxyisourate-hydrolase	unknown	unknown	gnl\|CDD\|376352
NC_012490.1\|WP_020907066.1\|2304554_2307266_-\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|182084
NC_012490.1\|WP_041814841.1\|2311389_2312190_+\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NC_012490.1\|WP_003940853.1\|2325470_2327111_-\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|227136
NC_012490.1\|WP_020907067.1\|2307262_2308072_-\|FAD-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366378
NC_012490.1\|WP_041814843.1\|2323047_2324352_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|367155
NC_012490.1\|WP_020907076.1\|2318178_2319642_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|334202
NC_012490.1\|WP_020907074.1\|2312899_2313325_-\|DUF1707-domain-containing-protein	unknown	unknown	gnl\|CDD\|377959
NC_012490.1\|WP_041815792.1\|2309446_2310364_-\|urate-oxidase	unknown	unknown	gnl\|CDD\|274554
NC_012490.1\|WP_020907068.1\|2308079_2309450_-\|8-oxoguanine-deaminase	unknown	unknown	gnl\|CDD\|236184
NC_012490.1\|WP_019747746.1\|2317154_2318060_-\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NC_012490.1\|WP_003940792.1\|2312549_2312900_-\|hypothetical-protein	unknown	unknown	unknown
NC_012490.1\|WP_019747745.1\|2316741_2317158_-\|SufE-family-protein	unknown	unknown	gnl\|CDD\|376883
NC_012490.1\|WP_020907077.1\|2319641_2321135_-\|acyltransferase	unknown	unknown	gnl\|CDD\|334202
NC_012490.1\|WP_007731146.1\|2324475_2325117_-\|septum-formation-inhibitor-Maf	unknown	unknown	gnl\|CDD\|178901
NC_012490.1\|WP_020907071.1\|2310754_2311273_-\|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline-decarboxylase	unknown	unknown	gnl\|CDD\|184333

Protein	Function_ID	Function_description	E-value
NC_012490.1\|WP_020907075.1\|2315336_2316737_-\|hypothetical-protein	gnl\|CDD\|334202	pfam00668, Condensation, Condensation domain. This domain is found in many multi-domain enzymes which synthesize peptide antibiotics. This domain catalyzes a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pfam00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site.	1.24108e-20
NC_012490.1\|WP_020907073.1\|2312190_2312553_-\|hypothetical-protein	gnl\|CDD\|227939	COG5652, COG5652, Predicted integral membrane protein [Function unknown].	0.000642826
NC_012490.1\|WP_020907078.1\|2321285_2322983_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.69363e-62
NC_012490.1\|WP_019747751.1\|2325132_2325474_-\|acyl-CoA-carboxylase-subunit-epsilon	gnl\|CDD\|379386	pfam13822, ACC_epsilon, Acyl-CoA carboxylase epsilon subunit. This family includes the epsilon subunits of propionyl-CoA carboxylase, EC:6.4.1.3, and acetyl-CoA carboxylase, EC:6.4.1.2. These enzymes are involved in the biosynthesis of long-chain fatty acids. The epsilon subunit is necessary for an efficient interaction between the alpha and beta subunits of these enzymes.	1.60453e-11
NC_012490.1\|WP_020907070.1\|2310428_2310758_-\|hydroxyisourate-hydrolase	gnl\|CDD\|376352	pfam00576, Transthyretin, HIUase/Transthyretin family. This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyze the conversion of 5-hydroxyisourate (HIU) to OHCU. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.	1.54052e-48
NC_012490.1\|WP_020907066.1\|2304554_2307266_-\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|182084	PRK09800, PRK09800, putative hypoxanthine oxidase; Provisional.	6.30274e-168
NC_012490.1\|WP_041814841.1\|2311389_2312190_+\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	1.31192e-76
NC_012490.1\|WP_003940853.1\|2325470_2327111_-\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NC_012490.1\|WP_020907067.1\|2307262_2308072_-\|FAD-binding-domain-containing-protein	gnl\|CDD\|366378	pfam00941, FAD_binding_5, FAD binding domain in molybdopterin dehydrogenase.	7.50299e-15
NC_012490.1\|WP_041814843.1\|2323047_2324352_+\|HNH-endonuclease	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	8.5374e-35
NC_012490.1\|WP_020907076.1\|2318178_2319642_-\|hypothetical-protein	gnl\|CDD\|334202	pfam00668, Condensation, Condensation domain. This domain is found in many multi-domain enzymes which synthesize peptide antibiotics. This domain catalyzes a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pfam00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site.	5.24138e-15
NC_012490.1\|WP_020907074.1\|2312899_2313325_-\|DUF1707-domain-containing-protein	gnl\|CDD\|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	1.57117e-20
NC_012490.1\|WP_041815792.1\|2309446_2310364_-\|urate-oxidase	gnl\|CDD\|274554	TIGR03383, Structure_Of_Uricase, urate oxidase. Members of this protein family are urate oxidase, also called uricase. This protein contains two copies of the domain described by the uricase model pfam01014. In animals, this enzyme has been lost from primates and birds. [Central intermediary metabolism, Other].	5.94099e-137
NC_012490.1\|WP_020907068.1\|2308079_2309450_-\|8-oxoguanine-deaminase	gnl\|CDD\|236184	PRK08203, PRK08203, hydroxydechloroatrazine ethylaminohydrolase; Reviewed.	0
NC_012490.1\|WP_019747746.1\|2317154_2318060_-\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	2.07893e-99
NC_012490.1\|WP_019747745.1\|2316741_2317158_-\|SufE-family-protein	gnl\|CDD\|376883	pfam02657, SufE, Fe-S metabolism associated domain. This family consists of the SufE-related proteins. These have been implicated in Fe-S metabolism and export).	1.79337e-42
NC_012490.1\|WP_020907077.1\|2319641_2321135_-\|acyltransferase	gnl\|CDD\|334202	pfam00668, Condensation, Condensation domain. This domain is found in many multi-domain enzymes which synthesize peptide antibiotics. This domain catalyzes a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pfam00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site.	7.70908e-18
NC_012490.1\|WP_007731146.1\|2324475_2325117_-\|septum-formation-inhibitor-Maf	gnl\|CDD\|178901	PRK00148, PRK00148, Maf-like protein; Reviewed.	2.78195e-103
NC_012490.1\|WP_020907071.1\|2310754_2311273_-\|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline-decarboxylase	gnl\|CDD\|184333	PRK13798, PRK13798, putative OHCU decarboxylase; Provisional.	1.53875e-66

>NC_012490.1|WP_020907074.1|2312899_2313325_-|DUF1707-domain-containing-protein
MADVPDIRIGTAEREQALDLLSEHFAAGRLTVTEFDERSGIVSAATTRSELVPVFADLPGNYQAPGTAPLSMVTPPAAPAERRFNPDWSGRVMAVIPILAVILFFVTGTWLWFLAIPLAGALLFGTDRERKAKRRRERDSD
>NC_012490.1|WP_003940792.1|2312549_2312900_-|hypothetical-protein
MEPIEINAGGWYLRALRADERVDDRPALADGGITDPDYVSQRSAQWHENSVYSWAVCQPNTGELLAEVVLTPLDSTALLTGWARDGHTEALTTAADAVTRFAEGALGLVVVEGQTN
>NC_012490.1|WP_020907073.1|2312190_2312553_-|hypothetical-protein
MKNNRYWPLAIAVVIALIMLFSPGSTVPSSPENTDKITHTLMFAVLAITSLHARIPAWLTAVWLVIFAATSEVLQAALPISRSGSIWDGTADLLGIAIGIGIVSLVMRRRRARDDEPSRS
>NC_012490.1|WP_041814841.1|2311389_2312190_+|tyrosine-protein-phosphatase
MTDTPKLSSVVPSLANLRDIGGPESSFGGTVRTGSVFRSTDLASLSAEGAQTLADLGIVTIYDLRTESERETAPDLTPDGIRELGLDVLADKQYRAIPAQMQQMIADPAFAAEALGSGQALEYFQGSYRDFVTLPSAVASYRQLFVDLAQPPSSPALIHCTTGKDRTGWAAAALLLFLGASEDAVFADYLETNKVLLPMFAPLLERFEAKGIDPTLLEGVLGVRREYLEASMAELAQVHGSIEAYFTDGLKIDASTQEQLRSNLLS
>NC_012490.1|WP_020907071.1|2310754_2311273_-|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline-decarboxylase
MPTTNSSGLGAFDTLGDHQAVAALLECCHSAVWAQEIASSRPFTDLEALFDKADAVLAELPESEIDDALSGHPRIGERSESAASTREQSEVSSATEDVLAELRQKNAEYEETFGHVYLVCASGKSGTELLDILRGRLRNDPATERSVLRTELAAINRIRLARLIDSLAGGAA
>NC_012490.1|WP_020907070.1|2310428_2310758_-|hydroxyisourate-hydrolase
MSKTLSTHVLDATTGIPAAGIRVELRDRDGVTITSAETDSDGRIPELAPGGLVTGHYTLTFDTGTYFETNGQENFYPEVTVTFRVDDTARGYHVPLLLSPFAYSTYRGS
>NC_012490.1|WP_041815792.1|2309446_2310364_-|urate-oxidase
MSGSIELTGHQYGKAENRVVRIYRDTPRHEIHDINVSTCLRGDFADAYLTGDQSKVLPTDTQKQTAYSYAKEKGLISIETYGLELARHFVDDIEPVSGARIEIEEYAWERAIVDGSEHDYTWIRKGQEVRTASITVSDTGTADAGTWVIGGLKDLVILKSTGSEFSGFLEDPYTILEPTDDRVMATTLVAQWRFVTTDVDWESVYVGIKAQIVKQFAQVHSLALQQTLFHIGKAILEEFPIIAEVRLSAPNKHHFEYALGRFGVENDNEVFHAADRPYGLIQAAVSRSDAPDAGPSWTPYSGWLS
>NC_012490.1|WP_020907068.1|2308079_2309450_-|8-oxoguanine-deaminase
MTDPALGTTLVVANAHVVTMDSERSEHPDGYVVISGNKIVDVGAGKAPVYPNAHVIDGNGCLITPGLVNTHHHLYQWITRGLAADSTLFEWLTTLYPVWAGIDADAVHVAATGGLTWLAKTGCTTTTDHHYVVPRDAGDVFEAEITAAAQVGLRFHPCRGSMDLGQSSGGLPPDHVVEKLDDILTGTQSVIDRWHDPNAGSMLQIAVAPCSPFSVTESLLRESATLARENGVRMHTHLAETLDEESFCRELFGCTPVEYMERVGWVGPDVWYAHAVHLDDAGIETMARTGTAAAHCPTSNARLGAGIARAADLVKGGVTVGLGVDGAASNEACSLIEESRHALLFARAKGGPQTMTVRKALELGTIGGARVLGREGEIGSIEVGKLADLAVWKLDTVAHAGITDPVAALVLGSTPPLKLLLVNGRIVVADGRVTTVDEDVVASDVARAHRDLLGKA
>NC_012490.1|WP_020907067.1|2307262_2308072_-|FAD-binding-domain-containing-protein
MDLHSVDEVLVPRTRAELPCASPGIGFIGGGTWLYSEPQPHLTTLVDLAGFDWKAVAVGDLGLEIAATCTIEELCRADLPTTWSAAALFQHCADALLASWKVLRYATVGGNIALSFPAGAMTTLCTALDAELTIWRPDGTEYSVPVVDFVIDDSRNVLGPGEIIRSIRIPVHALTARTAMRKLAQTSLGRSAVAVAGRCGADGFTLAITAATPRPYALKFDELPDAAALADALHCRIPEDAYFTDVHGTAPWRKAMTDLLAEEIRGELE
>NC_012490.1|WP_020907066.1|2304554_2307266_-|molybdopterin-dependent-oxidoreductase
MKYSVDGVPRDDQPRPGQCLRTFLREHGANSVKKGCDAGDCGACSVLVDGHPTHSCIFPAHRLGGRDVVTAGGLGTPEKLHPIQQAFVDAGGFQCGFCTAGMVVTASALSVEQKSDLACSMKGNLCRCTGYRSIRDALAGTSNTETAKTGGAQGRSIAAPASARIVTGTEQYTMDFSPGEKPIGLLHVAVLGSPHAHAHITRIDTAAAEAAPGVAAVLTFQDSPDVLFSTARHEDRNDDPDDTRVFDRTVRFRSQRVAAVIAETPTQAERALSLIEVDYEVLDAVFEPDLARSPGAPLLHGDKDESSRIAEVPRNVVAALHDGVGDLDRALADATAVVEGTWKTARVQHVALETHGAVGWLDEDGRLVIRSSTQVPFLVRDELAHIFDLDRSRIRVFAKRVGGGFGGKQELLTEDLVALAVLRTGKPVAYEFSRSDQFTIAPSRHPMRVSVRAGADADGTLTALAIDVLSDAGAYGNHSIGVMFHGCAESMAVYRAATKRVDAEAVYTNNVPSGAFRGYGLGQIIFAVESAMDQLADRLGMDPFEFRRRNVVVPGDDFVDWHVEDGDLEFGSYGLDQCIDLVDSALSSGRGEAAPAGSRWQIGRGMAIAMIATIPPRGHFSDTTVALEADGRYVVNIGTAEFGNGTTTIHQQIAATELRTTVDRITIVQSDTDAGGYDTGAFGSTGTVVAGKALLIACERLRERILTRAVRLSGRGAQIDDLSPDGVETSHGCLDFATLLEGGPLAADGRHDGTPRSVSFNVHGFRVAVDTDTGRVKILQSVQAADAGTVMNPAQLRGQVEGGVGQALGAALSEEIVIEEGRVINPQLRNYHVPQIGDLPITEVLFADTYDKLGPFGAKSMSEAPFNPVAPALANAIANACGVRMYSTPMTPDRVWSELQARA
>NC_012490.1|WP_020907075.1|2315336_2316737_-|hypothetical-protein
MEFTELADYAIPAGALVEWLPCATGPWVPDPRPVSYIHEAHLNRSAAGAGDKSWLGTAFEISGPLDVDAFRVALGRWIDRHEVLRSHTVLEPSSGEITRHTVPIGGIDIGVVSHGYDASSQDNFDHLHRLFDDYASPHSWPSYVFATLTPRGGDGPFTVFFAADHSIIDGFSIVLVAHEIAALYREASTGSAANLFPVGSYVDFGAVEREQMADMEAEKAAVEIWRKALGTDGLPQFPLPIGERGTDSQNGLSTWLLDAEQSKAFSSTCAAAGVGYFAGLLGGLAAVGREVAGSDQFEVVTPVHTRSAQAWAGALGWFVGLCPVEFAVGSDCSFGDLATRAAESIASVKPAAAVPFDRIGEHLETPIRPRFVVSYMDVRFVPEAAQWPEWNARALRSKAYTHDVYIWINRTPQGLNLAVRYPGNETANAAVHAYVAALRRTVEEIVAEPDTGTSGSYSSVVFETVS
>NC_012490.1|WP_019747745.1|2316741_2317158_-|SufE-family-protein
MSTLPSALAEIVDDFAAVGASDKLTLLLEFSRELPPLPAELEQSAMEPVPECQSPLFLSVDDSDRDNVRLYFSAPPEAPTTRGFASILAQGLDGHSADEILGVPDDFYSALGLAEAVSPLRLRGMSAMLARIKRHLRG
>NC_012490.1|WP_019747746.1|2317154_2318060_-|sulfurtransferase
MPVAPDPSTAFAEFAHPDRLVSTEWLSANLGTPGLKVVESDEDVLLYDVGHIPGAVKIDWHLDLNDPVTRDYIDGAKFAELMNRKGISRDDTVVIYGDKSNWWAAYALWVFTLFGHEDVRLLDGGRDAWIAENRDTAFDVPDITSTDYPVVKRNDAPIRAFKDDVLAHLGDGPLIDVRSPQEYTGERTHMPDYPEEGALRGGHIPSALSIPWAKAAAPDSRFRTRTELGEIYGGLSADDNIVAYCRIGERSSHTWFVLTHLLGYPNVRNYDGSWTEWGNAVRVPIVQGEEPGAVPSSVSAS
>NC_012490.1|WP_020907076.1|2318178_2319642_-|hypothetical-protein
MHVTSIDRYGLEPGIVTEWSLQPADGAVTESEVPPSYNQHFHLETARTHGMGRSVWMAAAFDLPGELNRPALDLALRLFISRHDTLHTGFEVGEFTTTRMGLDPDGTHIETSEPVKFDSTEDLRAHLKKRFTTVCDPLTFPAYTFATVEREEHYTVLSAFDHTLVDGYSLVIALGELRQIYEGLIAIPELTDHEAVDAVMSRLGDPGSFVRYCELEADALLPVDNDPRIREWARFYEICGGTSPSFPLDLGVEAGKPAPQGADVRVLLDEELTATFDEICLSAGGSVFTGILTAMGLSVHSFTGQATLPLQFPLHIRKDPRWADAIGWLTTSAPITVQITPDADFGASLAHTHASFRVALTLEGVTMAQVRDALGDKIRRTRTDVFMVSYIDYRKLPGTDDHDLLNAHHISNVTVADDAQFWISRTNRGLSLRSRFPDTDTANETMVNFLTDLDRILREVCARGVTPIGSVTEQLRDSSVGAGTPRI
>NC_012490.1|WP_020907077.1|2319641_2321135_-|acyltransferase
MDLNLITHWHPLPGRVIEWGVTHASAQRAAEAEIDRELPPTTMQDRHLRRARVTAEKGDPQSPWIGIAFDFAGTLDRDAMTRALQRYVRRHDTLHSWFSFDEATTDAADTAFEVRRHVVPVESIELEYRVGDDVSESEAIRALVATKFATETSALQWPAFVFGAVEHHHADLEADPSFTLFHAVDHAHSDMNSMVLMYAELRQLYAAETTGSHPELGPAGSYAQFGRVERERTTELTMQSPEVHQWLGYLMRSGGSFPGFPLPLGAEDAPKPAIGSRFDLADDNECERFGAVCKANGANFIGGIFTALAIAEFELAGRDKYIALSPVSTRTEADSFAQGWYINLIPVGIDVDDKRRFTELAKLGQQGYHDGKALLDVSVQQVIDLVLSSLAESDSAPGGLSKTLTPPPIVSYIDGRRMPDPYSYAETKATGIVGGKETQIASMWINRMHTGTWIAVSHPDTPIAHESATRFAEHVSKIIKTVAAQGDYSFSAPEGAS
>NC_012490.1|WP_020907078.1|2321285_2322983_+|MFS-transporter
MLPDPLGDAVGADHKGGRRAGSLTPWLGLATSLAAAFMQLLDATIVNVALPSIAVDLQAGVSAQLLMVSVYILAFACSLITAARLGDLFGRRVVFLTALFVFVAASLLCGLAQSATMLIVFRGLQGLAAGSMSAQTFAIISGLFPKARHPRVFGIYGATIGLATVSGPLIGGLLIEWNLFDWGWRLIFFVNIPIGIAALILGYFHLVDARAEHVRSLDLIGAALSSLALFLLILPLAEGRARGWPTGLVVMLAMSVPVALAFVLYESRLAKRGGDPVLRLELFRDRAFAIGAVLAFVFFGTLTSLIFTISLTLQFGFGFSALRAGVMTLPWAVGMGVAAVLSSAVYRMLGNRVLILGMVVFAGSLIALSVILEHEGTDPRWLALAGPLLLGGAGLGLFVAPLQTAILVTVEPAHAGSVSGLLPTVQQVGSSIGLALIGVVFFSLVAGQAPQAVQGERPEYVANLEAAGVNPGLVDIAEKAFVDCATSQLASGTPMEVAPECRREGTAGAGGQSVQVAVDAAYASTRAAAGEAFLEAQRRVLAIIAAIALGIGLASTALPRVNSPV
>NC_012490.1|WP_041814843.1|2323047_2324352_+|HNH-endonuclease
MSVLLSDVVSGSAVGLRGRLWRLTASELRAAAVSASVEILRLEAVRVAVVDELSLRPDDQVIASRGVGCWLAANTMLQVRDGKKIAALGAALRPFPAVAARFDVGDCSFDHAVLIVAFCESPPKGMPEEALPRGIDLLLAAASGVEATTTKVRNVIATLERVFESDEVPPAEDVDRNELRIASTLNGRVVVRGDFDALTGEMLLSALSNLTMPTPAPDGTPDARSAAKRTADGFTELIRRYLDCAKTGTDGGQRPHVNVHINARDLAEHRDCAAAPSPDGGGVAVSDLDVGHMPWLGPLSVSQTRLLGCDCFLSTVLLDDHGAPLDAKPGKRLVSAEQRVALIARDKGCAFPGCACVPAWTDAHHIRHWANGGPTVMSNLVLLCRSHHRLMHRKSGFVGKWVIRIGVDNKPWFIPPPSIDPGQHPRPANTTFKT
>NC_012490.1|WP_007731146.1|2324475_2325117_-|septum-formation-inhibitor-Maf
MTQLVLASASPARLAVLRAAGVSPLVRVSGVDEDKIADNLGPDAAPEKVVTVLAEAKAAEIVPGLAADNLTDVVVVGCDSMLLIDGQLQGKPGSVDIARKRWAAMAGRSATLLTGHCVLRVADGRIVRMASDHSATVVHFAQPSTEDLEAYLATGEPLQVAGAFTLDSLGGWFVERIEGDPSSVIGIGLPLVRTLLERVGVSVSDLWRTQSIF
>NC_012490.1|WP_019747751.1|2325132_2325474_-|acyl-CoA-carboxylase-subunit-epsilon
MTATTEDILSEDVALAETAPTNGAVVEGSATDASLTELTETSTSDASVIKIVKGSPTDVEIAALVSVLAAAAGSGQAPESNVPAETWGDPTQFHRTRAPFSPYAYLNPAIRRS
>NC_012490.1|WP_003940853.1|2325470_2327111_-|acyl-CoA-carboxylase-subunit-beta
MTTVQEPNAPEAAAAPDIHTTAGKLADLRNRQAQAQAPSGEAAIDKVHAKGKLTARERITALLDEGSFVELDALARHRSVNFGLADNRPVGDGVVTGYGTIDGRDVCVFSQDATVFGGSLGEIYGEKIVKVMDLAIRTGRPLVGINEGAGARIQEGVVSLGLYGEIFHRNVQASGVIPQISLIMGPAAGGHVYSPALTDFVVMVDETSQMFVTGPDVIKTVTGEDVTMEDLGGARTHMVKSGVAHYVASGEQDALDYVKDLLSYLPSNNQAAAPRGEITDPIVGSIEDSLTAEDIELDTLIPDSANQPYDMHEVIRRILDDDEFLEVQAERAMNIIVGFGRVDGRSVGIVANQPTQFAGCLDIDASEKAARFVRTCDAFNVPIITLVDVPGFLPGTEQEYNGIIRRGAKLLYAYGEATVGKITVITRKAYGGAYDVMGSKHMGADVNLAWPTAQIAVMGASGAVGFVYRKQLLEAAKNGEDVDALRLKLQNEYEDTLVNPYVAAERGYVDAVIPPSHTRGQIVSALRLLERKAVSLPPKKHGNIPL

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Crispr_ID: NC_012490_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012490_3

3337843-3338328

Orphan

Consensus_repeat	Method
GGANGAGCGGTTGCCCTGGTANCC	CRT

7 spacers

csa3

The CRISPR arrays of NC_012490_3

>merge|NC_012490|3|3337843-3338328|CRT
GGAAGAGCGGTTGCCCTGGTAACCGGTCGAGGGGCGGCTGTCGCGATCGCCGTACGAGCGGTTGTTGTCGCGGTTGCCCTGGTATCCACCACCGGACGAACGGTTGCCCTGGTATCCGCCGCGGCTCTCGCCGTCACGGCTTCCCTGGTATCCGCCCGAAGAGCGGTTGCCCTGGTAACCCGTCGACGGGCGGCTGTCGCGGTCTCCGTAGGCCGGACGGCTGTCACGGTTGCCCTGGTAACCACCGCTGGAGCGATCACCCTGGTATCCACCGGAAGAGCGGTTGCCCTGGTAACCGCCGCGGCTCTCGCCGTCGCGGCTTCCCTGGTAGCCACTGGAAGAGCGGTTGCCCTGGTATCCGGTCGAGGGGCGGCTGTCGCGGTTGCCCTGGTATCCGCCGCTGGAGCGGTCACCCTGGTATCCGCCGCGGCTCTCGCCGTCACGGTTGCCCTGGTAGCCACCGGAAGAGCGGTTGCCCTGGTATCC

>NC_012490|3|1|3337843-3338328|CRT
GGAAGAGCGGTTGCCCTGGTAACC	GGTCGAGGGGCGGCTGTCGCGATCGCCGTACGAGCGGTTGTTGTCGCGGTTGCCCTGGTATCCACCACC
GGACGAACGGTTGCCCTGGTATCC	GCCGCGGCTCTCGCCGTCACGGCTTCCCTGGTATCCGCC
CGAAGAGCGGTTGCCCTGGTAACC	CGTCGACGGGCGGCTGTCGCGGTCTCCGTAGGCCGGACG
GCTGTCACGGTTGCCCTGGTAACC	ACCGCTGGAGCGATCACCCTGGTATCCACC
GGAAGAGCGGTTGCCCTGGTAACC	GCCGCGGCTCTCGCCGTCGCGGCTTCCCTGGTAGCCACT
GGAAGAGCGGTTGCCCTGGTATCC	GGTCGAGGGGCGGCTGTCGCGGTTGCCCTGGTATCCGCC
GCTGGAGCGGTCACCCTGGTATCC	GCCGCGGCTCTCGCCGTCACGGTTGCCCTGGTAGCCACC
GGAAGAGCGGTTGCCCTGGTATCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012490.1\|WP_020907755.1\|3328490_3329369_-\|hypothetical-protein	unknown	unknown	unknown
NC_012490.1\|WP_020907757.1\|3333587_3334469_-\|DMT-family-transporter	unknown	unknown	unknown
NC_012490.1\|WP_019748452.1\|3344958_3346050_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NC_012490.1\|WP_020907756.1\|3332147_3333584_-\|GuaB1-family-IMP-dehydrogenase-related-protein	unknown	unknown	gnl\|CDD\|181127
NC_012490.1\|WP_020969619.1\|3327158_3328472_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NC_012490.1\|WP_020907763.1\|3348728_3349157_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NC_012490.1\|WP_020907762.1\|3347709_3348492_+\|hypothetical-protein	unknown	unknown	unknown
NC_012490.1\|WP_003944876.1\|3340921_3341335_-\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226207
NC_012490.1\|WP_019748444.1\|3330453_3331836_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NC_012490.1\|WP_041815970.1\|3351103_3351868_+\|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|176902
NC_012490.1\|WP_020907759.1\|3341526_3344100_+\|DUF2156-domain-containing-protein	unknown	unknown	gnl\|CDD\|378310
NC_012490.1\|WP_003944962.1\|3334473_3335976_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NC_012490.1\|WP_020907764.1\|3349244_3350660_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NC_012490.1\|WP_003944826.1\|3329372_3330461_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NC_012490.1\|WP_080910389.1\|3346046_3347507_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|182464
NC_012490.1\|WP_020907752.1\|3325623_3326658_-\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|239119
NC_012490.1\|WP_020907753.1\|3326650_3327127_-\|OsmC-family-protein	unknown	unknown	gnl\|CDD\|224678
NC_012490.1\|WP_020907760.1\|3344110_3344962_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NC_012490.1\|WP_007730904.1\|3336038_3337496_-\|NADP-dependent-phosphogluconate-dehydrogenase	unknown	unknown	gnl\|CDD\|236453
NC_012490.1\|WP_003944922.1\|3339942_3340896_-\|M56-family-metallopeptidase	unknown	unknown	gnl\|CDD\|320685

Protein	Function_ID	Function_description	E-value
NC_012490.1\|WP_019748444.1\|3330453_3331836_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.86281e-125
NC_012490.1\|WP_019748452.1\|3344958_3346050_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	9.8841e-86
NC_012490.1\|WP_020907756.1\|3332147_3333584_-\|GuaB1-family-IMP-dehydrogenase-related-protein	gnl\|CDD\|181127	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein.	0
NC_012490.1\|WP_020969619.1\|3327158_3328472_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.58755e-39
NC_012490.1\|WP_020907763.1\|3348728_3349157_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	1.12152e-28
NC_012490.1\|WP_003944876.1\|3340921_3341335_-\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|226207	COG3682, COG3682, Predicted transcriptional regulator [Transcription].	7.40352e-30
NC_012490.1\|WP_041815970.1\|3351103_3351868_+\|metalloregulator-ArsR/SmtB-family-transcription-factor	gnl\|CDD\|176902	cd08893, SRPBCC_CalC_Aha1-like_GntR-HTH, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. Some proteins in this subgroup contain an N-terminal winged helix-turn-helix DNA-binding domain found in the GntR family of proteins which include bacterial transcriptional regulators and their putative homologs from eukaryota and archaea.	5.72826e-57
NC_012490.1\|WP_007730904.1\|3336038_3337496_-\|NADP-dependent-phosphogluconate-dehydrogenase	gnl\|CDD\|236453	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase.	0
NC_012490.1\|WP_003944962.1\|3334473_3335976_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	1.75114e-122
NC_012490.1\|WP_020907764.1\|3349244_3350660_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	7.1744e-156
NC_012490.1\|WP_003944826.1\|3329372_3330461_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.85006e-93
NC_012490.1\|WP_080910389.1\|3346046_3347507_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	3.9566e-90
NC_012490.1\|WP_020907752.1\|3325623_3326658_-\|nucleoside-hydrolase	gnl\|CDD\|239119	cd02653, nuc_hydro_3, NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. .	1.98691e-143
NC_012490.1\|WP_020907753.1\|3326650_3327127_-\|OsmC-family-protein	gnl\|CDD\|224678	COG1764, osmC, Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism].	9.64726e-24
NC_012490.1\|WP_020907760.1\|3344110_3344962_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	1.38741e-130
NC_012490.1\|WP_020907759.1\|3341526_3344100_+\|DUF2156-domain-containing-protein	gnl\|CDD\|378310	pfam09924, DUF2156, Uncharacterized conserved protein (DUF2156). This domain, found in various hypothetical prokaryotic proteins, has no known function.	1.10169e-91
NC_012490.1\|WP_003944922.1\|3339942_3340896_-\|M56-family-metallopeptidase	gnl\|CDD\|320685	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase. This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.	5.19068e-31

>NC_012490.1|WP_007730904.1|3336038_3337496_-|NADP-dependent-phosphogluconate-dehydrogenase
MSTTSTESPRAQIGVTGLAVMGSNIARNFARHGHTVALHNRSIAKTDALIAEHGSEGDFVRTETVEEFVAALQKPRRVLIMVKAGAPTDAVIEELANAMEPGDIIIDGGNSLYTDTIRREAAIRARGLHFVGAGISGGEEGALNGPSIMPGGPKESYEALGPLLESISAHVDGTPCCTHIGPDGSGHFVKMVHNGIEYADMQLIGEAYNLFRDALGYDAGQVADVFTEWNKGTLESYLIEITAEVLRQVDAETGKPLVDVIVDAAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSRNQRAAAQAQGLAAGSLGDKPADAEQFAADIQAALYASKIVAYAQGFDQIAAGSAEYDWNLKPADLATIWRGGCIIRAQFLNRIKDAFDADPSLPSLILAPYFREAIEAGIDSWRRVVATATMLGIPVPAFASSLSYYDGLRAERLPAALTQGQRDFFGAHTYERIDKPGKFHTLWSGDRSEIEA
>NC_012490.1|WP_003944962.1|3334473_3335976_-|DEAD/DEAH-box-helicase
MQESTIDSPTSTEGRSFVDLGIPAVMVHALRRSGIDAPFPIQSATIPDVLAGRDVLGRGATGSGKTLAFGLPMLVRLKGGASKRNRPRGLVLAPTRELAIQIHKALDDAATEIGLRVANAVGGVPIKRQADILARGVDLLIATPGRLLDLLEQKSVILDDVVITTIDEADHMADMGFIDEVAKILDTTPKDGQRLLFSATLDGKVDDLVAGYLRNPASHSTAPPVATVSTMEHHLLFVDRDDKRSVVAHIASRAGRTIMFVKTKHGVDRLAQQLHLIGVSAGALHGGKTQNNRTKTLASFSDGTTPVLVATDVAARGIHVDDVTLVVHVDPPAEAKDYLHRAGRTARAGESGVVVTIVTDEERDSVEKLTKQAGIKVHGVRVRPDDLELTRITGAMEPTGIPVEAPDTTVAVKHTAKRGRQEHDTAGRTAAGGRMKKDGDKRAASSRRVTDPKSVKKIRADGTPVPTRSERLASKGLTPRRGAPGAGKPSAGNRAGKRAH
>NC_012490.1|WP_020907757.1|3333587_3334469_-|DMT-family-transporter
MGDLPLISVLCALVAALLFACASVAQQRAASAVPEGEALVASLIRSPRWWAGLIGDGGGYVMQAVALSLGSVLVVQPLIVTSLLFALPLSARFSGIRITRSAWSLAIMLAISLAIFLVVGDPTEGDSNAPWSDWAVPLTITVAVAVVATIGGLSKLDGGWRALLLGSAAGIFYGVAVAFTKYVTDLLGHGVVGVISAWQTWALIASGAIGVYLQQRAFQVGPLSASLPALTIGEPIAAIFLGMTVLDERLRVDGPGIALIGCAVAVMIMTTIALSRSQARDTEGATAESTVGS
>NC_012490.1|WP_020907756.1|3332147_3333584_-|GuaB1-family-IMP-dehydrogenase-related-protein
MQFLEGQRPPYDLTYDDVFLVPNRTEVTSRFDVDLNSSDGSGTTIPVVVANMTAVAGRRMAETVARRGGLVIIPQDVPTDAVAETVAFVKSRHLVADTPVTLSPDDAVSDALALLPKRAHGAVVVVEDGKPLGVVTEAACADVDRFTRLRTVAITDFVTAPVTATPREVFELLETKHDPLAVIVNEDGTLAGVLTRTGAIRAGIYDPAVDDRGALRVAAAVGVNGDVGAKAKALVDAGADVIVVDTAHGHQQRMIDALTTLKALDLGVPLVAGNVVSAQGTRDLIAAGADIVKVGVGPGAMCTTRMMTGVGRPQFSAVAECAAAARELGKHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLKVDQAGNAYKESFGMASKRAVAARTATETAFDRARKGLFEEGISSSRMRLDPERPGVEDLIDQICSGVRSTCTYAGARSLEELHEKAVLGVQSAAGFAEGRPLPSGW
>NC_012490.1|WP_019748444.1|3330453_3331836_-|HlyC/CorC-family-transporter
MDIVFTILSLVGFIALTAGTALFVAAEFSLTALERSTVDEAARGGDRRSRQVQHAHKTLSFQLSGAQLGITITTLITGYLAEPVLARFITPVTKAVGLSESAASTTSLILALVIATSFSMIFGELVPKNLAISKPMPTARATAGLQAGFSLIFRWAINGLNGTANWIVRRLGIEPAEELRSARSPQELGSLVRTSAQRGSIDKGTAMLVDRSLQFGDRTAEELMTPRVKIESLELSDTVADLIVTASRTGYSRFPVVRGDLDDTVGVVHIKHAFTVPAERRRTTRVDSLAQRVPVVPSSLDGDTVMERIRSDGMQVALVVDEYGGTAGIVTMEDLIEEIVGDVRDEHDEPELDVQRVGDGWSCSGLLRIDEVTSATGYTAPEGDYDTLGGLVLTELGRIPDEGDEVELPDVDSSGDSRGKWIARVTSMDGRRIDRVTITPVPAHVEPESADDDTKESDDE
>NC_012490.1|WP_003944826.1|3329372_3330461_-|HlyC/CorC-family-transporter
MNNLFGVLLTVVLLAGNAFFVGAEFALISARRDRLEALVAQGKKRALTVIKAGENLSLMLAAAQLGITICSILLGKVAEPAIAHLLEVPMEAVGLPDGLLHPISFAIALSLVVVLHILLGEMVPKNIALAGPEKTAMLLVPVHLAFIKIARPIIAFYNLCANGVLKLLRVEPKDELDVTVSAVELSAMIGESRSEGLIDAEEHRRLKQALESTDRTVSEVLITLDKVRTIPLTPSGTTLGEIERAVIETGYSRYPVRASDGSLAGYVHLKDVLDEVLDEAAGPDTVVPTSDIRPLPIVPLSTPLAEALAGLRRASSHLGAVTDADGVVIGIVALEDLLEEYVGTVRDGTHRGTDAVPGQRNS
>NC_012490.1|WP_020907755.1|3328490_3329369_-|hypothetical-protein
MTRSVHSLALAQSEWTVRRALHLEEVEKLVEPHRARRSAGISHPVHDFLFTYYNFKPAQLRRWHPGYGVALENAGEYAAFSGYRVDESGTATVEAAVLERRRHTVEFVWNLLNQTSARPAVLGCFGLHEWAMVYRGGEDAIRHQSVPLRLGFAGTDAVVESLPLKCTHYDAFRFFTPDAAPKNSLPLARETQIDHEQPGCLHAGMDLYKWSFKLLPLVDSDLVMRCFEHALLARELDMRASPYDLAEYGYSPIRIETPAGRAEYVRQQQQLADRAAPLRDTLAEKCRELLGH
>NC_012490.1|WP_020969619.1|3327158_3328472_-|CoA-transferase
MDHGYGFYLDEYQRDVGVHTDDRRGHIECPDSAGFLAAHLPVFDLAAGSVAAFASAIHRSTSPGDGHWTLDPERIAASFSSDRLFRIGGEPINGFSEYSGFFAARDGWVRTHGNYPHHRDRLLAILELDHGSPKDAVAQRISELSAIEIEQQAAEIGAIAVRVRTETEWRLSEQCAAARSEPLVSIRVRDEGKPRTHPTRPRVLDLTRVIAGPVATRALALVGADVLRIDPPAIPEIGWQHLDSGQGKRSALLDLKSSAEAAAFRELLDTADVLVTGYRPGALEALIGQDLPAHLIHGRVSAWGWEGPWANRRGFDSIVQAASGISFLEGGEKPGALPAQALDHSTGYFLAAGILDALTLRSHDGRGRDVDVSLASTGARLLDAPGRTVHPGLPTAPGLNAVVNHADVTTARPALAEFEDYPEPSHPWGSDRAEWAH
>NC_012490.1|WP_020907753.1|3326650_3327127_-|OsmC-family-protein
MKSHTYTLDLQWTGDLGTGTSSTQGYSRNHAISAVGKPELLGSSDPSFRGDAQRWNPEELLVASLAQCHMLWYLGLAAAAGVVVLDYNDQPVGSMIEESDGGGQFIEVTLNPTVLVAEASMVEKAEELHGPAHTKCFIARSVNFPVLHSPTILVATDE
>NC_012490.1|WP_020907752.1|3325623_3326658_-|nucleoside-hydrolase
MSDTHKLIVDVDTGIDDSLALLYLLASPEAEILGIASTAGNVPVEQVAANNLNWLALCGAPDIEVALGAREPLVIPLRTTEETHGPQGIGHAVLPDSGRKRSVRTATDLWVDLVREYPGQLTGLVTGPLTNLALAIRREPDLPSLLKRLVVMGGSFNYPGNTTPTAEWNVSVDPHAAKEVFDAFSVVPAHRRPIICGLNVTESIEMFPEHVRRLAEAAGSTPEEIISPDDGPDVRSSASNSVIRHMSDAIRFYMEFHREYDQGFLAHMHDPFAAAVALDPSLATLKPATVDVETESPLLIGTTVADWVGHWKREPNADIAVSTDPAEFFDRLVHRVGNYARVVG
>NC_012490.1|WP_003944922.1|3339942_3340896_-|M56-family-metallopeptidase
MNATTALVFGLLALLLAGPVPALLSRSTWPYRAPRAALVLWQAVAIAAVLSAFSSGLAIASQLLVPGADGRPTTAPTAEIDALGLPLWILYVVVFALTLLIGAKLIFSIIQVAVRTRRRRARHRVLVDLLDDCAMPASVERTPDLRVLDVDEPIAYCLPGLRQRVVLSQGTLQNLDHAEVKAILTHERSHLRARHDLVLEAFTAVNHAFPRFVRSKSALGSVQLLVELLADDSAVRATGPTPLARALVACAGSTAPRGAMAAGGPSTLIRVQRLSADDADPRIAVFAYLGAVAILVVPTVAVAVPWLTELRLLFNAY
>NC_012490.1|WP_003944876.1|3340921_3341335_-|BlaI/MecI/CopY-family-transcriptional-regulator
MAGLGELERAVMDHLWSTSEPQTVRQVHEALATHRELAYTTVMTVLQRLAKKHLVIQQRDDRAHRYLPVNKREELVASLMVDALAQAPESGGRAAALVHFVGQVNADEADALREALAALEVRESAKKAAQPGISRPN
>NC_012490.1|WP_020907759.1|3341526_3344100_+|DUF2156-domain-containing-protein
MTIDSSPGTEESTSRARVVTQKAAGIIRFGIRDAPLTVVLLLTMWILGAATGSLVHGPSRDLEHTIGAGMGSIQHGHVWIPLSSALWAGNLLGYIGASVLLIAVAAPLERRMGTIKLAIAGASTQILGVLLGLGWASFVKVFDSNWGFRLHVGSAVGASAWIVGAAMAASSNMGTLWRRRIRVGTLALTITLALFSGQLQDVIRFFAAVVGLVIGQWIVGRSARGERIAGTQREGRVLVAIVVAASAIGPMIAALSPQAVGPLAVLRDLFRGVPWTVAEVRELCAESASDPDCRRGLLELRLSGIGPTLLSLMPSIFVLVLSDGLRRGRRFAWIATVCAQVVLLVLSIGNFVIRFVDAVDSDSLFYGISDPNVYRTLVPFLTPLFVLILLIATRRYFDVAAPAKTYRRLGAAIVALLAVLAVIYVGGGMLARHGFDREPTVTMLLADFPQRLVPPVYLQLIDPRLLPVDIESTLLFEWTGVVFWGVAALLVFVSFLKPVKTADPTAAERARSMLIAGTGSPLSWMTTWKGNTYWFSADGSSYVAYRVIAGVALTTGDPVGPPDRMRAAIEGFAEFASSNGWIPCFYSVTDDARTITDSMGWSGLQVAEETVLDLGQVAFTGKRFQDVRTALNRAKKSGITAEWISFPHAPLAIKDQIVAISEEWVADKGMPEMGFTLGGLDEVEDEQVRGLIAVDEDRTVHGVTSWLPVYRDGKVVGWTLDFMRRRSEGFRPAMEFLIASAALKLEEEGVEFLSLSGAPLATIAGDSERNANEPEATTFSAMMDSVLDLLGRTLEPVYGFRSLLAFKSKFQPRYVPMHMTFADPAALPSIGNAVGRAYLPTVTIGQGFKLVRTILGR
>NC_012490.1|WP_020907760.1|3344110_3344962_-|ABC-transporter-ATP-binding-protein
MTTIAQSTDAPSRLVAQNLTLGYGDRIIVDGLDLEIPTGVITTVIGPNGCGKSTLLRALGRLLKPKGGSVILDGKAISSMKTKEVARVLGMLPQTPVAPEGLTVADLVSRGRHPHQSWIRQWSADDEGEVAEALELTGVSDLADRPVDQLSGGQRQRAWISMALAQGTDILLLDEPTTYLDLAHSMEVLDLVDQLHEEMGRTVVMVLHDLNLAVRYSDHLIVMRDGAVVASGVPKDIISAELLLEVFGLEAAVIDDPVSDRPLIVPIGTRHVFGAVGGPAKPA
>NC_012490.1|WP_019748452.1|3344958_3346050_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MTLKQELRVLPRTVPSRKSIRLGGFSLVYRPLAVSVSIALAVALFLLLCINIGRGDYPISIPDVISVLLGNGSKTQNLIVFDLRLPRSLTALFIGMALGIAGAVTQTIARNALASPDILGITAGSSAAAVALIVLGGGGSFVGLLATLGIPLAALCGGLLTAVVIYALAWRKGVEGFRLILIGIGINAMLVAATGWLLISADINDASRAQVWLNGSLNGATWNQMWPVAIAVAVVGGYAVIASFTMGALRLGDDNATSLGVRLQSSQAKLLLSAVALAAIATAAAGPVGFVALAAPQVAMRLVRSAGPPIVASALTGAVLVVGSDVIARTILPVELPVGIVTSALGGPFLLYLLVRNNRKVTA
>NC_012490.1|WP_080910389.1|3346046_3347507_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MIKSLGNGHPRGPSETYGRRIVPRGPAPVRMRVLAGLFDAAVFLLPLIVGWYIVQSLRDENGGGEADRAVFGGTAIAIAVGLLVWNLGFREGATGRTSGKGWVGLVTRDATTKQPIGVRRALRRPFDRSGIEVVRESTARDEGFEELARDNSVGATRRRRLIGLAVLTVLLALVMLASIAVGARPLTFAEIFHALFNSDGTQTDIIVRTLRAPRTILGLVVGIALGIAGALIQGHTRNPLADAGLLGLNAGAAFFVVMAIYLFGFTAPSQYLWFAFAGSFVASIVVFGLSSIGNGGASPLSLALAGAAVAFFLQAMTNAVIILDQTSLDAYRFWVVGSVSGRGFDVLWQVLPFLILGLVIALASTPGLNVLSLGEDVAKALGTNIAFSRTLGIVAITLLTGAATAACGPIAFIGLVVPHVARAITGPDYRWLVPYAGLLGAVMLITADIIGRVVVRPGELQVGIILALFGAPFFIALVRRRKLASL
>NC_012490.1|WP_020907762.1|3347709_3348492_+|hypothetical-protein
MTITLTTQHADVREFELRSNALSRTSVRLRALNPDYPRVYAVAAMAGEGKRRWWQLSEGLCGDRVHQMFARSLQDLDSAEAAAIQVATSLIHAVVGRVAASIVSEGSAWDPGLENLFIHMDSDGGIDWAGVVDETLRVAPNGRESGSDGVVDMPCEEALLVWTAHRCLTSLRAIYDAVARCAPVDQFRFWGLVGESILGAAAYVPILAGEGESAAQRRGQGLLDAFVAAGLPVRARRKVSLRPRWNQFDEGLAKLGQPCL
>NC_012490.1|WP_020907763.1|3348728_3349157_+|PaaI-family-thioesterase
MVDTAETAEMMKRLGTGFDATIGLEYTELSPDRVKAQWTVKPTLHQPAGIQHGGVYCSVVESLASVGGTVWLGERGHVVGVNNNTDFLRATREGTLTAEATPIHRGRTQQLWEVRITDENGRLVSKGQVRLANITEVAKIGN
>NC_012490.1|WP_020907764.1|3349244_3350660_-|NAD(P)/FAD-dependent-oxidoreductase
MSIQSVEPHRHRVVVIGSGFGGLFGTQALKKADADITMIARTTHHLFQPLLYQVATGILSVGDIAPATRLVLRKQKNAQVLLGEVETIDLENQTVTSRLLERVTVTPFDSLIVAAGAGQSYFGNDQFAEFAPGMKTIDDALELRGRILGAFEQAELSDDPAERARLLTFVVVGAGPTGVELAGQIAELSRRTLDGAFRKIDPREARVVLLDGAPAVLPVYGGKLSRKAAETLEKLGVEIQLDAMVTDVDNDGLIIREKDGTLRRIESQCKVWSAGVQASPLGKQLAEQSGGETDRAGRVMVNPDLSLPGHPNVFVIGDMMSLDKLPGLAQVAMQGGKYAAKQIKASLDGKSPSERVPFKYFDKGSMATISRFSAVAKVGKLEISGFIGWVAWLAIHLLYLVGFRSRASTLLSWAVTFFGRGRAQMASTEQQVFARNAMGELEKKNKEATESGSTSNGEAKKAAGKQQKAAG
>NC_012490.1|WP_041815970.1|3351103_3351868_+|metalloregulator-ArsR/SmtB-family-transcription-factor
MNAAFKALADPTRRLLLDRLFVANGQSLGELCESLDMSRQAVTQHLTALEDANLISTVRQGRTKLHYLNPVALEEIRERWINKFEVPRLHALSAVKKLAEEAMTDKPSFVYVTYIASTAENVWKALTDAGATAEYWGHSNVSDWQPGSTWEHRRIDGSNIADVVGTVVESSPPSRLVTTWADPNGEPGVDISRVSFDIEAFGAIVRLTVKHTDLADESARMEVAGGWSAVLSNLKSYLETGNTLPVAPWEMPVG

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Crispr_ID: NC_012490_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012490_4

3429180-3429259

Unclear

Consensus_repeat	Method
CCCCACGGCTGTTGCTGGCCGGG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NC_012490_4

>merge|NC_012490|4|3429180-3429259|CRISPRCasFinder
CCCCACGGCTGTTGCTGGCCGGGTTGTTGACCGGGCTGCGGTGTTTGACCAGGCTGACCCCACGGCTGCTGCTGGCCGGG

>NC_012490|4|3|3429180-3429259|CRISPRCasFinder
CCCCACGGCTGTTGCTGGCCGGG	TTGTTGACCGGGCTGCGGTGTTTGACCAGGCTGA
CCCCACGGCTGCTGCTGGCCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012490.1\|WP_020907800.1\|3422396_3423143_-\|cobalt-precorrin-6A-reductase	unknown	unknown	gnl\|CDD\|236144
NC_012490.1\|WP_020907801.1\|3423912_3425196_-\|bifunctional-cobalt-precorrin-7-(C(5))-methyltransferase/cobalt-precorrin-6B-(C(15))-methyltransferase	unknown	unknown	gnl\|CDD\|225151
NC_012490.1\|WP_003944925.1\|3440408_3440603_-\|ubiquitin-like-protein-Pup	unknown	unknown	gnl\|CDD\|368536
NC_012490.1\|WP_019748499.1\|3420529_3421171_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_012490.1\|WP_003944836.1\|3433302_3433578_-\|Sec-independent-protein-translocase-subunit-TatA	unknown	unknown	gnl\|CDD\|234797
NC_012490.1\|WP_021344319.1\|3429440_3432152_-\|RNA-helicase	unknown	unknown	gnl\|CDD\|226947
NC_012490.1\|WP_020907807.1\|3433712_3434690_-\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_012490.1\|WP_020907798.1\|3420159_3420519_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319903
NC_012490.1\|WP_020907808.1\|3434689_3435703_-\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_012490.1\|WP_019748510.1\|3432200_3433229_-\|twin-arginine-translocase-subunit-TatC	unknown	unknown	gnl\|CDD\|376413
NC_012490.1\|WP_020969665.1\|3426410_3427547_-\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|223085
NC_012490.1\|WP_020907802.1\|3425192_3425954_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235527
NC_012490.1\|WP_020907804.1\|3427584_3428550_+\|5'-3'-exonuclease	unknown	unknown	gnl\|CDD\|214682
NC_012490.1\|WP_020907809.1\|3438772_3439537_-\|proteasome-subunit-alpha	unknown	unknown	gnl\|CDD\|163403
NC_012490.1\|WP_021344323.1\|3437316_3438735_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|214487
NC_012490.1\|WP_019748502.1\|3423166_3423916_-\|precorrin-4-C(11)-methyltransferase	unknown	unknown	gnl\|CDD\|225430
NC_012490.1\|WP_019748505.1\|3425984_3426410_+\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NC_012490.1\|WP_019748515.1\|3439533_3440412_-\|proteasome-subunit-beta	unknown	unknown	gnl\|CDD\|163402
NC_012490.1\|WP_041815003.1\|3421330_3422296_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|381743
NC_012490.1\|WP_020969669.1\|3435813_3437157_-\|Pup--protein-ligase	unknown	unknown	gnl\|CDD\|274725

Protein	Function_ID	Function_description	E-value
NC_012490.1\|WP_020907800.1\|3422396_3423143_-\|cobalt-precorrin-6A-reductase	gnl\|CDD\|236144	PRK08057, PRK08057, cobalt-precorrin-6x reductase; Reviewed.	9.67558e-100
NC_012490.1\|WP_020907801.1\|3423912_3425196_-\|bifunctional-cobalt-precorrin-7-(C(5))-methyltransferase/cobalt-precorrin-6B-(C(15))-methyltransferase	gnl\|CDD\|225151	COG2242, CobL, Precorrin-6B methylase 2 [Coenzyme metabolism].	4.69557e-66
NC_012490.1\|WP_003944925.1\|3440408_3440603_-\|ubiquitin-like-protein-Pup	gnl\|CDD\|368536	pfam05639, Pup, Pup-like protein. This family consists of several short bacterial proteins formely known as (DUF797). It was recently shown that Mycobacterium tuberculosis contains a small protein, Pup (Rv2111c), that is covalently conjugated to the e-NH2 groups of lysines on several target proteins (pupylation) such as the malonyl CoA acyl carrier protein (FabD). Pupylation of FabD was shown to result in its recruitment to the mycobacterial proteasome and subsequent degradation analogous to eukaryotic ubiquitin-conjugated proteins. Searches recovered Pup orthologs in all major actinobacteria lineages including the basal bifidobacteria and also sporadically in certain other bacterial lineages. The Pup proteins were all between 50-90 residues in length and a multiple alignment shows that they all contain a conserved motif with a G [EQ] signature at the C-terminus. Thus, all of them are suitable for conjugation via the terminal glutamate or the deamidated glutamine (as shown in the case of the Mycobacterium Pup). The conserved globular core of Pup is predicted to form a bihelical unit with the extreme C-terminal 6-7 residues forming a tail in the extended conformation. Thus, Pup is structurally unrelated to the ubiquitin fold and has convergently evolved the function of protein modifier.	1.82663e-13
NC_012490.1\|WP_019748499.1\|3420529_3421171_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.98897e-12
NC_012490.1\|WP_003944836.1\|3433302_3433578_-\|Sec-independent-protein-translocase-subunit-TatA	gnl\|CDD\|234797	PRK00575, tatA, Sec-independent protein translocase subunit TatA.	4.36359e-31
NC_012490.1\|WP_021344319.1\|3429440_3432152_-\|RNA-helicase	gnl\|CDD\|226947	COG4581, COG4581, Superfamily II RNA helicase [DNA replication, recombination, and repair].	0
NC_012490.1\|WP_020907807.1\|3433712_3434690_-\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.01911e-53
NC_012490.1\|WP_020907798.1\|3420159_3420519_-\|VOC-family-protein	gnl\|CDD\|319903	cd07238, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.4089e-42
NC_012490.1\|WP_020907808.1\|3434689_3435703_-\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	3.73355e-47
NC_012490.1\|WP_019748510.1\|3432200_3433229_-\|twin-arginine-translocase-subunit-TatC	gnl\|CDD\|376413	pfam00902, TatC, Sec-independent protein translocase protein (TatC). The bacterial Tat system has a remarkable ability to transport folded proteins even enzyme complexes across the cytoplasmic membrane. It is structurally and mechanistically similar to the Delta pH-driven thylakoidal protein import pathway. A functional Tat system or Delta pH-dependent pathway requires three integral membrane proteins: TatA/Tha4, TatB/Hcf106 and TatC/cpTatC. The TatC protein is essential for the function of both pathways. It might be involved in twin-arginine signal peptide recognition, protein translocation and proton translocation. Sequence analysis predicts that TatC contains six transmembrane helices (TMHs), and experimental data confirmed that N- and C-termini of TatC or cpTatC are exposed to the cytoplasmic or stromal face of the membrane. The cytoplasmic N-terminus and the first cytoplasmic loop region of the Escherichia coli TatC protein are essential for protein export. At least two TatC molecules co-exist within each Tat translocon.	3.74522e-77
NC_012490.1\|WP_020969665.1\|3426410_3427547_-\|aminopeptidase-P-family-protein	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	2.71078e-93
NC_012490.1\|WP_020907802.1\|3425192_3425954_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235527	PRK05599, PRK05599, SDR family oxidoreductase.	3.49828e-95
NC_012490.1\|WP_020907804.1\|3427584_3428550_+\|5'-3'-exonuclease	gnl\|CDD\|214682	smart00475, 53EXOc, 5'-3' exonuclease.	1.71597e-76
NC_012490.1\|WP_020907809.1\|3438772_3439537_-\|proteasome-subunit-alpha	gnl\|CDD\|163403	TIGR03691, 20S_bact_alpha, proteasome, alpha subunit, bacterial type. Members of this family are the alpha subunit of the 20S proteasome as found in Actinobacteria such as Mycobacterium, Rhodococcus, and Streptomyces. In most Actinobacteria (an exception is Propionibacterium acnes), the proteasome is accompanied by a system of tagging proteins for degradation with Pup. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.35235e-137
NC_012490.1\|WP_021344323.1\|3437316_3438735_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|214487	smart00046, DAGKc, Diacylglycerol kinase catalytic domain (presumed). Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.	2.25589e-22
NC_012490.1\|WP_019748502.1\|3423166_3423916_-\|precorrin-4-C(11)-methyltransferase	gnl\|CDD\|225430	COG2875, CobM, Precorrin-4 methylase [Coenzyme metabolism].	7.56116e-125
NC_012490.1\|WP_019748505.1\|3425984_3426410_+\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	1.69893e-26
NC_012490.1\|WP_019748515.1\|3439533_3440412_-\|proteasome-subunit-beta	gnl\|CDD\|163402	TIGR03690, 20S_bact_beta, proteasome, beta subunit, bacterial type. Members of this family are the beta subunit of the 20S proteasome as found in Actinobacteria such as Mycobacterium, Rhodococcus, and Streptomyces. In Streptomyces, maturation during proteasome assembly was shown to remove a 53-amino acid propeptide. Most of the length of the propeptide is not included in this model. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	5.6306e-128
NC_012490.1\|WP_041815003.1\|3421330_3422296_-\|HAMP-domain-containing-protein	gnl\|CDD\|381743	cd06225, HAMP, Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.	1.63436e-09
NC_012490.1\|WP_020969669.1\|3435813_3437157_-\|Pup--protein-ligase	gnl\|CDD\|274725	TIGR03686, pupylate_PafA, Pup--protein ligase. Members of this family are the Pup--protein ligase PafA (proteasome accessory factor A), a protein shown to regulate steady-state levels of certain proteasome targets in Mycobacterium tuberculosis. Iyer, et al (2008) first suggested that PafA is the ligase for Pup, a ubiquitin analog attached to an epsilon-amino group of a Lys side-chain to direct the target to the proteasome. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	0

>NC_012490.1|WP_020907804.1|3427584_3428550_+|5'-3'-exonuclease
MSGPLLLLDGASLWFRAFYALPESFVDPDGRPVNAVRGFTDMVASLITKHQPSRLAVCLDLDWRPQFRVDAVPTYKAHRVEEGSDGSSEEVPDTLTPQVDMIMDVLAAAGIATAGAVGLEADDVLGTLAATEREDLTVVVSGDRDLLQVVTDEYVPVRVLYVGRGLSRAELFGPVEVAEKYGVPGDRAGEAYAELAVLRGDASDGLPGIKGVGEKTASTLMLRYGSLAGLRAAAADPESDMAKGIRAKLTSPEAIAHLDAALPVVRVVRDADVQFSKDDQLPATPADPARFEEVAASLNIERSAGRLAAALAAAAAGRSDQ
>NC_012490.1|WP_020969665.1|3426410_3427547_-|aminopeptidase-P-family-protein
MTSPAEQDSRFSSAVYGARIARAAELARSAGLDGLVVTPGPDLRYLTGSRADSFERLTALVIAADTAKASVVLPRLELASLKESAVGDLGLTVLDWVDGVDPYAIVAAQLPTGAKVAVTDAMPALHLIPLADTLGALPILATGVLRELRMVKDDAEIEALRRAGAAIDRVHARMAEFLIVGRTEAEVGEAISEAILEEGHTEAAFVIVGSGPHGADPHHEVSDRVIESGDIVVIDIGGPVEPGYNSDSTRTYSMGQPSAEVSAQFAVLEAAQQAAVDSVRPGVSAESVDVAAREVLAAQGLAEVFVHRTGHGIGLSVHEEPYIVEGNTIELVEGMAFSIEPGIYFRGSWGARIEDIVVVTADGCESFNNRPHGLTVLG
>NC_012490.1|WP_019748505.1|3425984_3426410_+|PPOX-class-F420-dependent-oxidoreductase
MTLTPSTTPSAQQTLTEDGLKFVGEYHLATLTTLRPNGTPHVVAVGFTWDQEAGKARVITSGGSQKAINAARGGYAAVSSVDGGRWLTLEGPARVLADEDSVADAVRRYAERYRQPRVNPARVVIEIDVTRILGSAAFKES
>NC_012490.1|WP_020907802.1|3425192_3425954_-|SDR-family-NAD(P)-dependent-oxidoreductase
MTAGANVNDIETVLLLGGRSEIGLEIAVRLAPGRNIVLAARRSGELSEQEQMLRNAGAVGVSTVEFDADAVDTHGDLLGAVVAEHGRISVAVLAFGILGDQARAETDAAHAVAVVHTDYVAQISILTHLAEIMRRQGTGKIVVFSSVAGVRVRRANYVYGSAKAGLDGFASGLGDALHGSGVQLMLVRPGFVIGKMTEGMSPAPMSSTPSQVADAVVRGLNSGATRVWVPRILQPVFFVMRLLPQTIWRRMPR
>NC_012490.1|WP_020907801.1|3423912_3425196_-|bifunctional-cobalt-precorrin-7-(C(5))-methyltransferase/cobalt-precorrin-6B-(C(15))-methyltransferase
MTAHPVVIVGIGADGWEGLSESAKGAILGAEVLMGSPRQLDLVPAAHLGARRAPTRLTWPSPMIPALPSMFAENADRKVCVLASGDPMFHGLGVTLVRLLGADNVRVISHPSSVALASARMGWASSEVDVVSLVNRDSATVLAAVVDGARLLVLSNGRSTPGEVARLLSGAGFGRSTLTVLAQLGGAEESRTVTVADEWDHADEDVDALNVLAVECISVDHPLRLTRIPGLPDAAFVGDGQMTKQEIRALTLCALAPAPGEHLWDVGGGSGTVAIEWMRTHPRCTATAFEKVASRVSQIGANALNLGVPALAVKGTAPEAFAEEVRRPDAVFVGGGVTQPGMLEACWEQLSVGGRLVANAVTAESESLLLGWMSRQGGTLRRFQVQRAEPLGAFNVWRPQLPVVQWSVTKSQPSAGAGTDTPEESTQ
>NC_012490.1|WP_019748502.1|3423166_3423916_-|precorrin-4-C(11)-methyltransferase
MTVHFIGAGPGAADLITVRAQRIIAASPVCLYAGSLVPAELLEWCPVGAQVVDTARLSLDEITAILVEAHSAGLDVARLHSGDPSIFSAVAEQARRLDAAGVDFDMIPGVPAFTAAAAALRRELTVPGVSQTIVLTRVSTLSTAMPEGEDLRSLGRSGATMVVHLGAHRIEQIASELADNYGEDCPVAVVAFASRPEEIVVRGTLKTIVELVHAAGITKTAVVIVGRVLTAEGFPDSYLYSAARERSTH
>NC_012490.1|WP_020907800.1|3422396_3423143_-|cobalt-precorrin-6A-reductase
MLLLGGTGEGRVIASRLADSADLEVVTSLAGRVRDPRWPEGEVRIGGFGGAEGLSEWLSNNDIRAVLDATHPFAARITKNAFDACRANSVPYAMYRRPPWREQPGDTWLPVRNLDHAAELVPTVGSRAFLTIGRQGVSAFDRVKDVSFLVRSIDPPSGTLPPHSQLLLARGPFDVEAEVDLMRTHGIDVVITKNSGGEQTYAKIAAARKLSIPVIVVERPPIPATAPAFDTEAGAVDWLTAFGSGTAL
>NC_012490.1|WP_041815003.1|3421330_3422296_-|HAMP-domain-containing-protein
MSVPGMSRRKPSGIHVRTLHARVKLLTAGLVAIAVIVSASAVYIVFNAYLQGNVDRQLERTSDAITDTVNFGGVTPVLGLTAGADTAVIQAVGLLTADGALVTATPGLPPFSTSADAIRSIADGNSSQTIATVDAYRILVEPSVAGQTLVVAQSLGPTRSVLKRLAVVLAALGGAGIALAYAAGDAVARTGLRPIARLTAATRRVAETDDLAPIPVTGDDELASLTVSFNRMLGTLSESRARQRSLITEAGQDLLAPLTALRTNIELLMSFDTKSGAISEADATQLREEITDQMMELTLLVGELVDRARVDESTLGRGDSL
>NC_012490.1|WP_019748499.1|3420529_3421171_-|TetR/AcrR-family-transcriptional-regulator
MVKQARAELTRQQIVAGAAAQFEKTGYGSTSMADIVSGAGTTKGALYFHFASKDELAQFIIAEQHRLSIESVQAISATGKDPLEQMIMLTHEMARQIVDEPIVRAGIRLTLELSTYEGPVEPYAEWISAITDLTARAQAEGEIRKSVSAESFGRFMPSAFTGVQLVSNVLTRRSDLPDRVDEMWQILLPGIVSDELSGDIERLVKSRWTPAAA
>NC_012490.1|WP_020907798.1|3420159_3420519_-|VOC-family-protein
MAVTRIVSDLSSSSLEAAQRFYTEVLGLEVVMDHGWIVTLASPTDPSSQISVMTHDAHAPVVPDVSVEVDDLDAAYEAAVQRGDTIVYPVTEEPWGVRRFFAADPDGHVINILSHRREQ
>NC_012490.1|WP_021344319.1|3429440_3432152_-|RNA-helicase
MNKSELSTFASSLKFELDPFQVKACVALEAGHGVLVCAPTGAGKTVVGEFAVHLALAAGRKCFYTTPIKALSNQKYAELVERYGPSEVGLLTGDSSINSDAPVVVMTTEVLRNMLYANSEALRGLSHVVMDEVHYLADRFRGAVWEEVILHLSEDVRLVSLSATVSNAEEFGSWMETVRGDTTVVVDETRPIPLWQHIMVGRRIFDLFDSRSHPAAGPKTVLVDQDLVRHVKQRQALERVESWQPRGRGRRGSYQSSNDFRPLPRPDVIAQLDQSGLLPAITFIFSRAGCDAALAQCLRSRLDLTSPEQVREIDTIIEKHTGELPEEDLEVLGYRDWCKALRRGLASHHAGMLPAFRQTVEELFVKGLVRAVFATETLALGINMPARTVVLERLVKYNGESHAELTPGEYTQLTGRAGRRGIDVEGHAVVLWQPGVEPTDVAGLASTRTFPLRSSFRPSYNMSINLVERMGAADSRKLLERSFAQFQADRSVVGLVRGIERNEEALKGLQEKLGGADGEYFEYASLRERLSARERALERKGREDRRGDAVESLRALARGDVIAIPIGRHSGVAVVLVPDNDPKDPRPLVLTADQWAGRLSSGDFPEAADVLGKMRLPKHVDHHTARIRRDLASALRSTGISAPRRKKRHKAGASEDAEVATLRRAIRSHPCHSWPDREHLSRIGERYNRLARETQSMREKAAATTNSLARTFDRIIALLKEREYMTAEAAPEVTESGRRLSRIYSESDLLVAECLRTGAWTGLSPAELAAVVSSVVYESRRDGDTVDRVPTAALRHALNDTQRLWSELRSDEIRHKLPPTREPDLGFVTAVYHWASENSLVDALIAAGVQGRALSAGDFVRWCRQVIDLLDQVRLTSTDADVAKTAARAVAAIRRGVVAVDAA
>NC_012490.1|WP_019748510.1|3432200_3433229_-|twin-arginine-translocase-subunit-TatC
MRIPLDPRNRKRKVNPDGTMSLVDHLYELRTRLLFAFLGVIITTAFGFFWYSHSILGLESLGDLLRGPYCELPSESRANLSTDDACRLLATGPFEQFMLRFKVALTAGIVLACPVWLYQLWAFITPGLYAKERRYAVGFVTAGAALFILGAILAYLVVAKALHFLLTIGDNVQITALSGSEYFGFIINLLLIFGVSFEIPLLVVVLNFAGILTYERLKAWRRGLIFGLFVFAAVATPGSDPFSMLALALALTLLFEVAVQIARLNDKRKAKRAGEDWGALSDEEASSISSPSDLNEAFDNPTKPKAESSGLFGRKSKSKAPVAEKSDTGGDNAPGQDFTDTL
>NC_012490.1|WP_003944836.1|3433302_3433578_-|Sec-independent-protein-translocase-subunit-TatA
MGAMQPMHWLIVAVVVVILFGSKKLPDAARGLGRSLRIFKSEVKEMQNDDAAPASAPVAQPAPAQLPTANTAVVANGAAAPVAQPTEVKPL
>NC_012490.1|WP_020907807.1|3433712_3434690_-|YafY-family-transcriptional-regulator
MSNRLSSRLARLLNLVPYFIANPGISPAEAAEELGVSTTQLMTDLNQLWVCGLPGYGPGDLIDLSFSEESIEVTFSAGIDRPLRLTSTEATALLIALRSLVEMPGMVDPSSAQRAIAKIEDAAGSAAARAIGQDRDTSPAPDIAEDPIAATVRAALADKTALRLTYYSASRDAVSERIVDPVRIVLVDNYSYLQAWCRQAEGVRLFRFDRIDAAVQLDEPADPPPQALEEDSNLELFSGDGSLPEARLFITKEWVWMLDYYPMDVEHVNGDGSVEATMSFGTLEWMARLVLGFGEGVRVLHPPELVSEVHDRAVAALDAYDVIGS
>NC_012490.1|WP_020907808.1|3434689_3435703_-|YafY-family-transcriptional-regulator
MATSKIERLMNLVIALLSTRQFLTAEKIRDSVAGYNDSANYEAFSRMFERDKNELRDLGVPLETGLAGRFSTVEGYRINRNAYELPDVDLTSEESAAVAVAVQLWESPELISAAQSALLKLRAAGVQVDSEVSAAPVTAIPARTRGSEPALGKLLAAVDAGRAVHFQHRGALNEPFTERTVEPWGVVTHNGKWYLVGHDVDRDAVRTFRLSRIGDDVREFGPAGSVHKPEGVDLREVVDRVTGSGVVTGIATVWVADGRAHELRRLATSSSDRRLTDRDGSVLAIPVRSWEWTARLIAGHGLDALVLDPPDLRAEVVAKLRAAAASPATSNDGQGDN
>NC_012490.1|WP_020969669.1|3435813_3437157_-|Pup--protein-ligase
MGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATAECDSLIQLVNHDRAGERVLEELLIDAEARLAEEGIGGDIYLFKNNTDSAGNSYGCHENFLVARAGEFSRISDVLLPFLVTRQLICGAGKVLQTPKAATFCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMAETTTMLKVGSAALVLEMIEAGVSFRDFALDNPIRAIREVSHDVTGKKPVRLAGGRQASALDIQREYHAKAVEHLRNREPDPQVEQVVDLWGRTLDAVEAQDFAKVDTEIDWVIKRKLFQRYQDRHGFDLSDPKIAQLDLAYHDIKRGRGVFDVLQRKGLVKRVTEDETIDDAVENPPQTTRAKLRGDFITAAQAAGRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDERVERLIASM
>NC_012490.1|WP_021344323.1|3437316_3438735_+|phosphatase-PAP2-family-protein
MESTGALRPSVLDPTMRFLSRAADHGVLWMVVAALLAMIGGRPRRAAARGMLALAGSSALANGILKPLFPRRRPPARVWLSPKRGVDIPTSSSFPSGHSSSAAAFTAAVAMESPAAGAALAPLAAAVAYSRVHNGVHWPSDVFAGLAVGGAIAAGTRRWWAVRDEEPAELGPECVVPALARGEGLLVFTNPGSGSEDDGIVESIRELLPEAIVYEFDADIDFDMQIDAKIPELSPKALGVCGGDGTVVTVATAATKHELPLAVFPGGTLNHFARDVGAVNVEETAQAVESGQAAFVDHAVVRTDSGVTARFLNTASLGGYPDAVRLREKWEPRFGKWPAAGAAMIRVLAAAEPMTVTIDGKRTTIWMLFVGNGRYSPADQVPMSRPEMNRGLLDVRYLRADKKFSRSRLLFAAATGTLGSSRVYVRELVSSMSVRVADSPVAIATDGEVVADARRFDFDTEPGAVAVYRITQ
>NC_012490.1|WP_020907809.1|3438772_3439537_-|proteasome-subunit-alpha
MTMPYYASAEQIMRDRSELARKGIARGRSVVVLTYRDGVLFVAENPSRALHKVSELYDRLGFAAVGKYNEFENLRRAGIVHADMRGYSYDRRDVTGRSLANAYAQTLGTIFTEQPKPYEVEICVAEIGRFGSSTPAQLYRITYDGSIADEQEFVVMGGTTEPIVTAMRESYQRDLDLESAVRLAVGALQKGGPAPAGTTEAEPRTLDVSALEVAVLDSNRPRRAFKRIAGSALEEMLPTPAATEDAPANGDAPS
>NC_012490.1|WP_019748515.1|3439533_3440412_-|proteasome-subunit-beta
MTVDRAPRITDGDTRLSFGSNLSSFSEYLRVHAPEHLPQNRFADTGGVVMGGGDVAPHGTTIVAISYAGGVLLAGDRRATMGNLIASRDVQKVYVTDDYSAAGIAGTAGIAIELVRLFAVELEHYEKIEGVPLTFDGKANRLSSMVRGNLGAAMQGLAVVPLLVGYDLDAVDPSRAGRIVSYDVVGGRYEERAGYHAVGSGSLFAKSALKKLYSPGIDEDTALRFAVEALYDAADDDSATGGPDLTRGIYPTAVTITSAGAVELSTAKAAEIAREIVAARTATASPEGESAL
>NC_012490.1|WP_003944925.1|3440408_3440603_-|ubiquitin-like-protein-Pup
MAQEQTQRAGGGEDDETTGGDGSAGQERREKLAAETDDLLDEIDDVLEENAEDFVRAYVQKGGQ

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Crispr_ID: NC_012490_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012490_5

4466297-4466430

Orphan

Consensus_repeat	Method
CGTTCGGTCGATCTGAGGCGACGAATGTACCGTTCGCTCGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012490_5

>merge|NC_012490|5|4466297-4466430|CRISPRCasFinder
CGTTCGGTCGATCTGAGGCGACGAATGTACCGTTCGCTCGAAATCGGGGGTGTGCCGGCCGTGCTCTTCTGCTCGTGATGGTGCGAACGGGGCGTTCGGTCGATCTGAGGCGACGAACGTACCGTTCGCTCGAA

>NC_012490|5|4|4466297-4466430|CRISPRCasFinder
CGTTCGGTCGATCTGAGGCGACGAATGTACCGTTCGCTCGAA	ATCGGGGGTGTGCCGGCCGTGCTCTTCTGCTCGTGATGGTGCGAACGGGG
CGTTCGGTCGATCTGAGGCGACGAACGTACCGTTCGCTCGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012490.1\|WP_019749286.1\|4472906_4473881_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236196
NC_012490.1\|WP_041815079.1\|4454802_4456149_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274819
NC_012490.1\|WP_019749294.1\|4487684_4488455_-\|hypothetical-protein	unknown	unknown	unknown
NC_012490.1\|WP_007732210.1\|4486734_4487682_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381307
NC_012490.1\|WP_020908418.1\|4488591_4489821_-\|hypothetical-protein	unknown	unknown	unknown
NC_012490.1\|WP_020908415.1\|4482007_4486126_-\|cation-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319840
NC_012490.1\|WP_020908411.1\|4473934_4474666_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|117022
NC_012490.1\|WP_020908416.1\|4486125_4486551_-\|hypothetical-protein	unknown	unknown	unknown
NC_012490.1\|WP_020908414.1\|4481714_4481996_-\|hypothetical-protein	unknown	unknown	unknown
NC_012490.1\|WP_020908413.1\|4476161_4481645_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|227111
NC_012490.1\|WP_020908403.1\|4453414_4454782_-\|NtaA/DmoA-family-FMN-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|274819
NC_012490.1\|WP_003940660.1\|4464052_4464628_+\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NC_012490.1\|WP_029538428.1\|4464710_4466099_-\|plasmid-pRiA4b-ORF-3-family-protein	unknown	unknown	gnl\|CDD\|377943
NC_012490.1\|WP_003945103.1\|4472423_4472834_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|226134
NC_012490.1\|WP_020908405.1\|4456323_4457229_-\|phosphodiesterase	unknown	unknown	gnl\|CDD\|277347
NC_012490.1\|WP_019749282.1\|4459526_4460645_-\|esterase-family-protein	unknown	unknown	gnl\|CDD\|223700
NC_012490.1\|WP_020970156.1\|4451869_4453363_+\|stealth-family-protein	unknown	unknown	gnl\|CDD\|371500
NC_012490.1\|WP_020908408.1\|4460756_4463939_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|350770
NC_012490.1\|WP_020908407.1\|4459114_4459474_+\|excalibur-calcium-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|377566
NC_012490.1\|WP_003940669.1\|4457568_4458942_+\|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl\|CDD\|366058

Protein	Function_ID	Function_description	E-value
NC_012490.1\|WP_019749286.1\|4472906_4473881_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236196	PRK08241, PRK08241, RNA polymerase subunit sigma-70.	0
NC_012490.1\|WP_041815079.1\|4454802_4456149_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	9.26099e-72
NC_012490.1\|WP_007732210.1\|4486734_4487682_+\|aldo/keto-reductase	gnl\|CDD\|381307	cd19081, AKR_AKR9C1, AKR9C family of aldo-keto reductase (AKR). Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).	4.17577e-145
NC_012490.1\|WP_020908415.1\|4482007_4486126_-\|cation-translocating-P-type-ATPase	gnl\|CDD\|319840	cd07539, P-type_ATPase, uncharacterized subfamily of P-type ATPase transporters. This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.	2.54377e-179
NC_012490.1\|WP_020908411.1\|4473934_4474666_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|117022	pfam08445, FR47, FR47-like protein. The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.	1.26655e-24
NC_012490.1\|WP_020908413.1\|4476161_4481645_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NC_012490.1\|WP_020908403.1\|4453414_4454782_-\|NtaA/DmoA-family-FMN-dependent-monooxygenase	gnl\|CDD\|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	6.57955e-152
NC_012490.1\|WP_003940660.1\|4464052_4464628_+\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	1.94164e-118
NC_012490.1\|WP_029538428.1\|4464710_4466099_-\|plasmid-pRiA4b-ORF-3-family-protein	gnl\|CDD\|377943	pfam07929, PRiA4_ORF3, Plasmid pRiA4b ORF-3-like protein. Members of this family are similar to the protein product of ORF-3 found on plasmid pRiA4 in the bacterium Agrobacterium rhizogenes. This plasmid is responsible for tumorigenesis at wound sites of plants infected by this bacterium, but the ORF-3 product does not seem to be involved in the pathogenetic process. Other proteins found in this family are annotated as being putative TnpR resolvases, but no further evidence was found to back this. Moreover, another member of this family is described as a probable lexA repressor and in fact carries a LexA DNA binding domain (pfam01726), but no references were found to expand on this.	1.49944e-49
NC_012490.1\|WP_003945103.1\|4472423_4472834_+\|VOC-family-protein	gnl\|CDD\|226134	COG3607, COG3607, Predicted lactoylglutathione lyase [General function prediction only].	1.04749e-58
NC_012490.1\|WP_020908405.1\|4456323_4457229_-\|phosphodiesterase	gnl\|CDD\|277347	cd07402, MPP_GpdQ, Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain. GpdQ (glycerophosphodiesterase Q, also known as Rv0805 in Mycobacterium tuberculosis) is a binuclear metallophosphoesterase from Enterobacter aerogenes that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. The GpdQ homolog, Rv0805, has 2',3'-cyclic nucleotide phosphodiesterase activity. GpdQ and Rv0805 belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.25655e-72
NC_012490.1\|WP_019749282.1\|4459526_4460645_-\|esterase-family-protein	gnl\|CDD\|223700	COG0627, COG0627, Predicted esterase [General function prediction only].	3.70144e-52
NC_012490.1\|WP_020970156.1\|4451869_4453363_+\|stealth-family-protein	gnl\|CDD\|371500	pfam11380, Stealth_CR2, Stealth protein CR2, conserved region 2. Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.	4.58065e-55
NC_012490.1\|WP_020908408.1\|4460756_4463939_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|350770	cd18012, DEXQc_arch_SWI2_SNF2, DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins. Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	9.00422e-108
NC_012490.1\|WP_020908407.1\|4459114_4459474_+\|excalibur-calcium-binding-domain-containing-protein	gnl\|CDD\|377566	pfam05901, Excalibur, Excalibur calcium-binding domain. Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognized and the evolution of EF-hand-like domains is probably more complex than previously appreciated.	2.54857e-17
NC_012490.1\|WP_003940669.1\|4457568_4458942_+\|dicarboxylate/amino-acid:cation-symporter	gnl\|CDD\|366058	pfam00375, SDF, Sodium:dicarboxylate symporter family.	1.97984e-105

>NC_012490.1|WP_029538428.1|4464710_4466099_-|plasmid-pRiA4b-ORF-3-family-protein
MSHLRLVPTEPEELQRFVQEAGGVRGGIQIARSLRSKRRAVPAQYAIRISVDNVSTQIWRRILVASDLNLGDLHSVVQRAMGWSDRHSHAWSKSGTRFPGEVEEYVASGSNAEQRLAGRVAIVESAVRLDEVMVSPGDELRYRYGRFGNWSHTLTLESSEVLPDGFQIVCAAGRGACPPEECVGPDEYEQLLGVLASEKLRSHEWTLEWPQTEFEPTRFEIAEVNNRLHIPRPDEIVAPYDTAMLVECLQPSRVPELRAVLARAGIDDESAIGELVHVEAGQRLQAVLTLIGVEGVDADDFFTTVDAMLDEPELGPVNLPKGRSLFAVLKRFGLVRKHKGQIVLTKRGQSAQRDASIMWSVIVDSVPVAPGGSQRAVELLVLLAVAAGLSPADRHRFVAGALESIRSSSILMSGAQTSKRDTSGSTVEVLGLIGATGYELGKFGTKADSPWAAHLARAILQR
>NC_012490.1|WP_003940660.1|4464052_4464628_+|TerD-family-protein
MGVTLAKGGNVSLSKAAPNLTKVAVGLGWDARSTSGADFDLDASALVTGPERKVLSDLHFVFYNNLRSPDGSIEHTGDNLTGEGDGDDEVINVDLPAVPPNVTNIFFPVSIHDADARLQSFGQVTNAYIRVVDLSNGSELARYDLSEDASTETAMLFGELYRHNGEWKFRAVGQGYASGLAGIARDYGVNI
>NC_012490.1|WP_020908408.1|4460756_4463939_+|DEAD/DEAH-box-helicase
MQPDSVRALDLDRVRAVVGTTTYERGLVYLRQNAVESIGWNDTADTLTGAVSGTAREPYTCTISVSRSAAGTATFTRGLCTCPVRMNCKHVVALVLAAVAEANKTPQHLGWDSALEELLRPDPAGRTTRGLGIQFTTRTKGASTRLIVKPVQPGARGWISGGLAWNKLGSTFQFPADHLRVLRDIHLLHSAGNYYRNQNAAEIDLAGFASPQLWSLLREAISVGVSLVHSKACLGNISLLDDASICLDVHGAEDNNLRLTPRIQAGGHIVTHSDWGLVGTPAHGVFALDDANAITLTPLHTPITHQLRQLIDSGKSVDIPAEHRDAFTSRFVFKLGNLAPVISSDGAYNPPTVSGPRLQLVATYADNHRIDIESAWKYTVDADELIISTADTTTDESEIRNHVAEDAIAKSLGAAAAKATLAGTLAGLDSMQFTLDLLPQLDANDDVDLTVVGTPADYRPADDAVVIGLSTSAPDWNSGSDWFDLDVTVDVAGQSVPFTTLFSALSKGETHILLPDGAFFRLDAPDLLGLHRLITEARSLLDRPTGKLAISKFQAGLWEELTALGRVEHQAAAWKKQIAGLLGSSGIDPVEVPDTLTATLRPYQVDGFRWLNFLRQHSLGGILADDMGLGKTLQTLAMICAARQSNPAAPPFLIVAPTSVVSNWKSEVAKFAPTLHTAVITDTLRRRKTDLAALVDGADIVVTSYALFRLDTDAYSAGRWSGLVLDEAQFAKNHKSKVHKCATAVNAPFKLAITGTPMENNLMELWSLLAITAPGLFPSPTTFTDVYRNPIEKEGDTERLAQLRRRVKPLMVRRTKEQVAADLPPKQEQILEIELHPSHRAIYDTHLQRERQKILGLLDDVDKNRFTILQSQTVLRQLSLDVSLVDEESGPVPSAKVDALVEQLDDVIAGGHRALIFSQFTGFLGSVRKRLEAEKIPYSYLDGSTRNRGEVLEEFKSGVAPVFLISLKAGGFGLNLTEADYCFILDPWWNPAAEAQAVDRTHRIGQTRNVMVYRLIAKDTIEEKVMALKAKKSALFSNVMDAEGTLGTGLDAEDLRALFE
>NC_012490.1|WP_019749282.1|4459526_4460645_-|esterase-family-protein
MRTERRAWIRSARTGAVCLAVCALSLQLGGLSTAAPSSGSSGSSGSLGSVEGSVSSGSTIPGPLQEDPGPKPELRDDIVVPAIVGEKVTAPQAVRLTVASPALRREVGVEILLPADNSVPRPALYMLEGVDAGEKSSGWMTIGGAPAFFADKNVNVVMLNGGIASLYSDWENPDPRLGLHKWETFITEELPPLIDARLKTNGINAIAGNSMGAMGAMMLAQRFPDMYRGVAVFSGCYSTMDPLGRTAVQATISSRSGDPANIWGVPGGPEWEAHDSLINAEKLRGKEIYVSTANGRPGSDETLQTPELLERLVIGGGIEVAAHACTKMFDARLQELKIPAQVDYEPNGTHAWAYWRERLPKAWPTLSRALGV
>NC_012490.1|WP_020908407.1|4459114_4459474_+|excalibur-calcium-binding-domain-containing-protein
MKLRRLAFSVAGCAAITLVATPAAQASTVFDFLPIEIARMIPTGSADAVQPFLPPVFAPPAPPAPQAPQNQPAPQNTPAPARYYQNCTAVRNAGAAPLYRGQNGYAPHLDRDNDGIACE
>NC_012490.1|WP_003940669.1|4457568_4458942_+|dicarboxylate/amino-acid:cation-symporter
MPSSTSTGVPEKSTSRFPSWATAFGPQIVAGLVLGVIIGLVARAMPDAADGNVNWLVGTVQTIGSSYVKLLTVAVIPLVFTAIVSSIANLRQVANAARLAVQTLLWFAITAFIAVIIGIIVGLITDPGSRTDVAAEAAKEPKSSGSWWAFITGLVPNNFLGLGAKTSVAEGVATTSLSFNVLQLLVIAGAIGIAALKIGPKAAPFLEFNASLLAIVQKVLWWIIRLAPIGTAALIANAVATYGWDAIGSLGVFTAAIYIGLAIVFFVVYPILIAAHGLSVRSFFSGVWPATQLGFVSRSSIGTLPLTERVTERNLGVPREYASFAVPLGATTKMDGCAAIYPAIAAIFVAGFYDVPLTFTDYLLIVVVSVIGSAATAGTTGATVMLTLTLSTLGLPLAGVGLLLAVEPIVDMGRTAVNVTGQALVPVIVAKREGILDKERFDAPRNGDPFAEELVDA
>NC_012490.1|WP_020908405.1|4456323_4457229_-|phosphodiesterase
MSVRSAEYPRPKHFLVHLSDTHLVAQGELYDAVDASTRLREVLSGIVASGARPDALIFTGDLTDQGHPDAYAELKAIVEPVAAEIDAQVIWAMGNHDDRSTFRSLLLGEDATDHPVDNVYDLDGLRVITLDSSVPGHHYGEISDRQLDWLRSELAVPAPDGTILALHHPPVPCIQDLAVLVELRDQSRLADVLRGSDVRAILAGHLHYSTTATFAGIPVSVASSTCYTQDLNVEVGGQRGRDGAQGCNLVHVYDETIVHSVVPLGAHVTVGEPVDADEGARRLSAAGIRILESEKAGRSIV
>NC_012490.1|WP_041815079.1|4454802_4456149_-|LLM-class-flavin-dependent-oxidoreductase
MSQAAVATRTVSRVLTVSAVGTVRSRVVLEQEYAPMTSTPSSHLAPLHLAVALDGAGWHPAAWREPHSRPSELFSASYWTDVVTTAERGLLDFVTIEDSLSVPANPLEPVDDAVDRVRARLDAHLVAARLAPITSNIGLIPTITTIHTEPFHVSKAVATLDYTSRGRAGWQVKVSASESEAAQFGRRDIPALTDADRQSIVSGVLPDFVRDLFDEAAEAADVIRRLWDSWEDGAEIRDVEQRRFIDRDKLHYIDFEGKYLSVRGPSVTPRPPQGHPVVTALAHQRVAYELAARTADLVFVTPFDDEQVTAILGEVRAAEEHVQRTGEPLRVFTDIVVFFDTPEETGKERLARLDAQAGAEYRSDALTFTGSAAELADLLLRWQQLGIEGFRLRPGVLVDDLDAIAGELVPELQRRSVFRTEYPQTNLRGLLGLPIDVPNRYAAGTPAA
>NC_012490.1|WP_020908403.1|4453414_4454782_-|NtaA/DmoA-family-FMN-dependent-monooxygenase
MSSQKRKQVILGAYLGGVNHHTAWWDPQAGSQIEFDSFEHTARTAERGKFDFFFLAEGLALRERAGQIFDQDIIGRPDTFTVLASLAAVTEHLGLAGTINATFNEPYELARQFATLDQLSGGRAAWNVVTSFDAFTGQNFRRGGYLDRAQRYERAQETVALVRELWDSWRSDDIVADKASGRFLARPDAGEFAFHGSHFDVNGRFTVPRSPQGRPVILQAGVSPQGRDFAAGNADAIFSPYGQLPEAADFYRDIKARAVAAGRDPGDIKILPSASFVLGTSEADAIEKYREIRDQQVTGQTALVLLEQIWNLDLSKYDPEGPLPDIAPDPEAPPIIQGRAFIHQDRFATVAKLRAVAESKKLNLREVVIDQFERGPIVGTPQQVAEKIDSFVSNDGSDGFILGSHLVPTGLDEFVDDVVPLLQDRGVLRSDYEGTTLRDNLGLPIPVQRERATAR
>NC_012490.1|WP_020970156.1|4451869_4453363_+|stealth-family-protein
MGELPETVRFKNRFALAITTTTPLEAMVEDLLFIRDILDAAGIEYLLVRGNDERPVIAVSWTERKNLRQALVEGCANAPFYSKTVDAKKSPALLVADGALSKTNKSRIFRLFRPRVHVASGMNYGANIGVQIELWSISDEEIVLPVENSLTRRTVLPEEAVRGTVERFGRIWPTIENMFADHASDISFDIDLVFSWVDGSSKEFQAQRAKRMQNYIVGEGDESEARFRQIDELKYALRSIHMYAPWIRRIFVATDSDRPDWLADDPRVTFMPSEKFFADPSVLPTHNSQAVECQLHHIPGLAEHFLYSNDDMFFGRPVGPDMFFSPGGISMFIEADTRIGLGHNDNDRSGFENAARVNRRLLQDRFGLMTTRHLEHAATPLRKSVMAEMEREFAEDFAATAASTFRASSNISVTNSLYHYYTLMSGRSVVQKSAAVKYVDTTVKAGLRDMDSLLAKRSMDFFCLNDGSAPEIDLELRTRKITEFLESYYPIPAPWEA
>NC_012490.1|WP_003945103.1|4472423_4472834_+|VOC-family-protein
MSRLLFVNMPVKDVAATRAFFSGLGFEFNDMFSDENTVSMIVSDSATVMFLNEPRFGDFIADDICDTSKAREALMCVSADSREEVDTFVDAAIAAGGSKWMEPQDHGFMYGRAFRDLDNHVWEVMWMDPAATVPQQ
>NC_012490.1|WP_019749286.1|4472906_4473881_-|sigma-70-family-RNA-polymerase-sigma-factor
MTVDQALDSDFLTLADPYRRELLAHCYRMMGSIHDAEDQVQETFIRAWRGFDGYKGQSSLRTWLYRIATNTCLTALEGRSRRPLPTGLGAPSSDPADDLIERNEIAWLEPIADSALGDVNDPAVMVVNRDSVRLALVAALQHLSARQRAVLVLRDVLQWKASEVAEALDTTTTAVNSLLQRARAQINHIGPTEDDLVEPSTEAARKLLRDYVHSFESYDVEAIVELFTREAIWEMPPFEGWYQGPEAIGQLIGTKCPADGPGAMRLLPTAANGQPAFGLYMREPDGVHRAFQLHVLDVTESGISHVTCFFDLSLFARFGLPAEL
>NC_012490.1|WP_020908411.1|4473934_4474666_-|GNAT-family-N-acetyltransferase
MTTEATLASFVETVDTDVDIHPLDDPVRQGLRGHHAQFAHWAGRVARYDPTVAPFVGHPPELDAEDWENLRTLVGPGGTVGLRGFDHQPPEGWRVVDQFGSVQMDGSALEVSVDPSVELLGRGDVPEILALIERTKPGPFLPRTVEMGSYYGIRVDGRLVAMAGERLHPPGWTEISAVCTDSDFRGRGLGTTLIRAVAAGIRERGELPFLHAVQSNTNAIRLYESLGFVLRKRSRLTAVQAPA
>NC_012490.1|WP_020908413.1|4476161_4481645_+|ATP-grasp-domain-containing-protein
MFKRIAVVNRGEAAVRLIRAVRELNAEHDYGIRVVALHTEAERRAMFVRQADEGVTLRSTGTGSPYLDYAELERALLAAKADAVWVGWGFVAEDPAFAEIVAKLGITFIGPSADAMRLLGDKVAAKILAEKVGVPVAPWSGGPVETRADARRHAQSIGYPLIIKARSGGGGRGIRKVWAEDELEVALERTQGEAERSFGDPVVFLERLVTDARHVEVQVIADNHGNVWAPGVRDCSIQRRNQKVIEESSSPVLTEEQSDHLKKVSAELVKAAGYQGAGTVEYLYQPENKLFTFLEVNTRLQVEHPITEVTTGIDLVKLQILVASGDELVGDCPPAFGHAVEARLNAEDADNDFAPAPGTVQLLKFPLGSGIRVDTGIAAGDVIPPDYDSMVAKVIAWGRNRSEALARLRTALRETTVVLDGGTTTKSFLLDLLDRDEVISASADTGWLDRTGALTGTTRRADVALIATAIDAYDAEESLERAAFLASARGGRPRANHAIGRTVELNYQGQAYKLTVGRIGPHRYRVDGDAGDIEVDVDRLGDFESRLVIGDRRFHVVSVVSPARYLVEVDGISHQISQDDAGVVRAPAPAVVVAVPVAVGDDVEAGSTLVVLESMKMETAVRAPYAGKVREVLATVNSQVDAGAPLLRVDQVSEEAVTEKAPRVQFDLPAATSGSDARDDALAQLEALTAMISGYDVSGKHANAVLAEYDALRSALESEDRELVQAELAVLTTFADICELSRNKPTSGESAKDESVHSPREHFHTFLHSLDSEREGLPASFRTRLERALRHYDVTDLEDRQAVEEAVYRLFLALQRMEAQIPVIAALLEGWLVGDKAPGCSAQELNEVLDRLIVATQVRYPVIGDVARNLRFRFFDEPRIRKVREDVYDGVRGNLAYLEEQPDAADFDERIANLVATPEPLLDLLGRKIGLGNRDGGPLLEVITRRYYKIHSFEDVRVFEHVDRRFVTGNFDLKGDGLHLVSTVAEFDALGTALDDVATIAQDAPSGRGLVVDIYLDWPNQPADGDTLVETLRTELSRNETITRSRRATVIICNPNGEPVRWVTFRPIDGELVEDNIIRDMHPLTGQRLDMWRLKNFNGKRLPAPENTYLFHLSAKENPKDERLIALAEIRDVTPQLDDEGQMVALPAIERTLAACLDGIRRAQSQRGDKRRLAANRVVLYVWPVADVPSERFSVIAQNAARLTVGAGLEEITLITRLKDRKGGVPKEVALRFSYRAGAGVVINKTTPPTEPLLPLDAYAQKVQSSRARGTVYPYELIPLLTGTKGTFVEHDFDEAGVLSPVERPYGLNKAGIVVGLVNTPTPRYPEGMTRVALFGDPTKALGTVAEAECSRVVAAIDLAEKLNAPVEWFALSSGATISMESGTENMDWVSRGLRRIITFTQNGGEINIVVTGINVGAQPYWNAEATMLMHTKGILVMTPDSAMVLTGKQSLDYSGGVSAEDNFGIGGYDRVMGPNGQAQYWAPDLTAACEILFRHYAHSYLAPGERFPRRAATTDPVDRDVRSFPHTHPSSDFETVGDIFSSAKNPDRKKPFDIRTVMRSVVDQDHSVLERWADMAGADTSVVLDAHLAGHPVTVVGIESRAIPRKGHFPADGPDTWTSGTLFPNSSKKTARAINAASGNRPIVVLANLSGFDGSPESLRNIQLEYGAEIGRAIVNFDGPIVFCVVSRYHGGAFVVFSGALNDNMEVLAVEGSFASVLGGAPAAAVVFTREVNTRTNNDPKVQQLEADLAAAKDDTEKAHLRVELNAQRIAVRSDKLGEVASEFEAIHNIQRAREVGSVDEIVPAAELRPQIIAAVERGMKRALAQ
>NC_012490.1|WP_020908414.1|4481714_4481996_-|hypothetical-protein
MSQNTVDQRNPVDHRAVVESVRSARTFELELPIVGAIPVPRPEQIAYFAVMGLMVAFEIIEWPVAVTIAAGHLLATEQHNHVLEEIGEALEGV
>NC_012490.1|WP_020908415.1|4482007_4486126_-|cation-translocating-P-type-ATPase
MFSAMARRAVSVATLPPRLALSGLALVGGSTIPRTAVSDVALRTGTLALAGVGMIPAAAGSILRVPRMPGSAYVLAAASAINYQPRVRRRIEQRLGRSLTDFALESATSFADVLTYAPASLGVDFGLRTMLLRETLAARNSRLVWPLEPGARGSSTRSDPSGPGERYADRIAGVQLAAGAALATVSAGGDTVATSIKVSAPRPLRMSRESFAAGLSYGLCRTHHVAVSDPAALRMLDRVDTVLVDPSVLFEDALRVSDIREVSESDRVVVWAHAREALDAGSLGVGRHRIDGAEVVVRPVRKGLAESLIGEIRASGVAAATIDDDGLGSLRSGFDELYPAQSTPEAGLREALSALVAEGRTVAIVSSRAIAGQAVLRIGISPPSGEHVSADIHTDLAGAWRVVHALSAARTATRRGVELSSGSSALGALIMLPGIRGAGPGPVTAGSAAGLWTGYTLSRSVIQAPAPVGAPSDSWHEMDGDSVVRELAESVRHTPQRADSGVRAPARFRLIRDGLSALRTELADPLTPVLATGSAASAVLGSPVDAVLVGSVLVGNAAMSAVQRLHSERAVQRLLRTQEPVARRVTNVGEVETAADALELGDVVALESGDIVPADCRLLSAESLEVDESSLTGESMPVDKQTDPTPGMPLAERRCMAYAGTTVLAGSGRGVVTATGARTVTRRADVGVSRSGPAVGLTNRLRELTRATLPASIGGGALVTVAGLIRGTGLRRAVTGGVAVAVAAVPEGLPLVATLAQQAAARRLTAAGVLVRAPRSIEALGRVDVVCFDKTGTLSENKLRVAAVERVDGWGESEILEVAARSALGSRDDRVFHSTDAAVVDAAEQALDEARVFGDADALNLVPFRSGRPYSAALLGRRIALKGSPEFVAEAGRDPNAVSASHVQSMAGRGLRVVAVAQRELSEHDARRAAEDSEFLEQCCSEGLEAVGLLGLSDTLRPEATQLVRELQGNGQQVRVLTGDHPTTAAAVATELGMDVAREDVVTGPDWENFSRAERRNAVRGSSVFARVTPEQKVEIVQALETDGRVCAMVGDGANDAAAIRVSSVGIGVASTDSDPARGAADIVLLDGRVGGLTDALDEGSQLWRRVRSAVGVLLGGNAGEVAFALIGSALSGESPLNARQLLLVNLMTDALPAAALAVSTPSENGSEKSEQMDTHALWQTIAVRGGATAIGALAAWLLARTSGRRRRASTVALVALVGTQLGQTLLESRSPLVVATVTGSAAALATLVSTPVVSQFLGCTPLGPIGWGQAVGCASAATLLAALAPRVLERIAATEETGTEESEEGQSTIRKIPTRTSTAYTSRTGGVSARDSVEISEAEIKEAETGESDTLVSVAAGSDTSPNSRATRDES
>NC_012490.1|WP_020908416.1|4486125_4486551_-|hypothetical-protein
MMIVDEATRVVRGVADATTTVAGAVGGGVIGGVTGGIRGTAEGVRDGIRAGSSSTPTAVLTMAAVGAAGLVEWPVLLAVGGTALVLHEWDRKSARPDRAVKAVGRATKTEPAKKESSGNSHKAASRSQDRTHSSSHTRSTS
>NC_012490.1|WP_007732210.1|4486734_4487682_+|aldo/keto-reductase
MAIIGNSDLDIFRLSLGGNPFGWTADEKTSFEILDSFAEAGANFIDTSDSYTASAPGNSGGESETIIGKWITDRGLQNDIVVATKVGSHPDFKGLKADNIAAAAEASLQRLQTDCIDLYYAHFDDPQTPLEETLEAFNALVVAGKVRYLGISNYSPDRVREWLRITEENGYAAPIALQPHYNLVHRKSYEPELAQIATDNNISVFPYFALASGFLTGKYKTRADIEGSSRERLTAGYFSDAGLDVVAELATIAQAHDSEISTVALAWLLTRPGITAPIASVSRPEQLPALLDAPNLVLSSNELDTLERVSAAVGA
>NC_012490.1|WP_019749294.1|4487684_4488455_-|hypothetical-protein
MEDTASRGINAFISEATQRGGKAVRLTHSRRNPVEVTGADGISRIVRVRSKLDGDWQARRQDESLESDDTRSEFWVFVDLAADPHEFFMLPSNEVADDIRAEVDLWIMDSPGRNRTGHHAIPRGRVVHGHDRWDALGLAAVKDPSIYVEAPVATKRKTSPVAAKKRRASGVEEIEVVDNRLEMTADCHGYRWVGRFDESTEVVEIMRGPMEGRRFPDPTAAANAVTGHISGDTESHDGWSFWTINNTALGAHLKTA
>NC_012490.1|WP_020908418.1|4488591_4489821_-|hypothetical-protein
MTDGREMADGNGDVFVVASVTERRTLISTRVREWCAAGTVESNRPELSDDVALLIAGGYADESTRSILANRRGVGRSFPEIGGFSELRYLTDELARTRRRLLATRIGPVQVVLERRVQTLDKRVQSMRSAIVHSNRHFASSVRAIRKDRRDGLHLDVEQREALFAGLTCTPVPAKLPVGLGVVASSGNAALDKLAAQFGKVQGTGVIADAGRRIAEVLDGLVDSEPEGRAGEYEALLYLAGNLFDRIESSSAWHSDHFVIQRNQLDLADEITQIAVDTVALRSILAELDDAAALARDEGTRAGIASRREALGTVWDQLVERVAALARIGDLVARAEDQLSSQRAVAHAASLDSRIDDLLARSGSRELSAANTHYVGDQFDGVEELMFAHRAALYGDIALLTSGNERRAP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2445428 : 2460760

Gordonia_phage(22.22%)

holin

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041814854.1\|2445428_2445665_+	hypothetical protein	A0A1B3AYT5	Gordonia_phage	1.3e-17	61.6
WP_020907147.1\|2445730_2446978_-	Fic family protein	NA	NA	NA	NA
WP_041814856.1\|2447221_2448220_-	hypothetical protein	NA	NA	NA	NA
WP_020907149.1\|2448276_2450244_-	hypothetical protein	Q5ZGD1	Flavobacterium_phage	6.4e-17	37.3
WP_041814859.1\|2450247_2450592_-	hypothetical protein	G9FHA2	Rhodococcus_phage	8.6e-18	46.3
WP_041814860.1\|2450579_2450984_-	hypothetical protein	G9FHA1	Rhodococcus_phage	2.6e-34	59.1
WP_020907152.1\|2451011_2451239_-\|holin	holin	NA	NA	NA	NA
WP_041815813.1\|2451365_2452139_-	peptidoglycan-binding protein	A0A142K908	Gordonia_phage	4.2e-57	64.0
WP_020907154.1\|2452164_2453031_-	hypothetical protein	NA	NA	NA	NA
WP_020907155.1\|2453030_2453474_-	DUF2744 domain-containing protein	A0A220NQQ4	Corynebacterium_phage	7.4e-14	38.3
WP_020907156.1\|2453475_2455158_-	hypothetical protein	A0A220NQQ5	Corynebacterium_phage	9.9e-160	47.0
WP_050768587.1\|2455154_2456036_-	hypothetical protein	G9FHK7	Rhodococcus_virus	4.9e-25	29.1
WP_148209229.1\|2456032_2460760_-	tape measure protein	A0A2H4JDP5	uncultured_Caudovirales_phage	7.7e-234	46.7

DBSCAN-SWA_2

2480470 : 2486430

Rhodococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020907187.1\|2480470_2481094_-	hypothetical protein	G9FH01	Rhodococcus_phage	8.2e-51	51.9
WP_020907188.1\|2481093_2481924_-	YqaJ viral recombinase family protein	G9FH00	Rhodococcus_phage	3.0e-125	79.2
WP_158304204.1\|2481920_2482073_-	hypothetical protein	NA	NA	NA	NA
WP_020907190.1\|2482185_2482461_-	hypothetical protein	A0A1C9EI31	Gordonia_phage	1.2e-14	42.9
WP_020907191.1\|2482457_2482649_-	hypothetical protein	NA	NA	NA	NA
WP_020907192.1\|2482645_2484187_-	DNA cytosine methyltransferase	A0A0K1Y7T4	Mycobacterium_phage	4.7e-164	57.5
WP_020907193.1\|2484183_2484471_-	hypothetical protein	NA	NA	NA	NA
WP_020907194.1\|2484467_2484635_-	hypothetical protein	NA	NA	NA	NA
WP_020907195.1\|2484631_2484985_-	hypothetical protein	NA	NA	NA	NA
WP_020907196.1\|2485105_2485291_-	hypothetical protein	NA	NA	NA	NA
WP_020907197.1\|2485358_2485526_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_041814877.1\|2485543_2485777_-	helix-turn-helix domain-containing protein	G9FGY4	Rhodococcus_phage	4.7e-12	52.2
WP_020907198.1\|2485923_2486430_+	HTH domain-containing protein	G9FGY3	Rhodococcus_phage	2.6e-23	44.7

DBSCAN-SWA_3

2536012 : 2542337

Lactobacillus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_019747884.1\|2536012_2536579_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	7.3e-06	33.9
WP_020907231.1\|2536651_2537479_-	siderophore-interacting protein	NA	NA	NA	NA
WP_019747886.1\|2537770_2538001_+	glutaredoxin-like protein NrdH	V5UN81	Mycobacterium_phage	1.5e-21	64.0
WP_003944767.1\|2538083_2538563_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A217ER62	Bacillus_phage	4.5e-09	30.1
WP_086935732.1\|2538544_2540704_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	6.9e-206	51.2
WP_003944744.1\|2540779_2541745_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A0N7CCA3	Skermania_phage	7.7e-157	86.8
WP_019747889.1\|2541863_2542337_-	NUDIX domain-containing protein	D0R7J3	Paenibacillus_phage	6.7e-13	31.2

DBSCAN-SWA_4

2700814 : 2717088

Bacillus_phage(20.0%)

protease,tail,head,capsid,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020907343.1\|2700814_2702134_+\|portal	phage portal protein	A0A0K1LLE7	Bacillus_phage	1.9e-25	29.1
WP_158304209.1\|2702316_2702931_+\|capsid	minor capsid protein	NA	NA	NA	NA
WP_050768593.1\|2703244_2703724_+	restriction endonuclease	NA	NA	NA	NA
WP_041814935.1\|2703667_2704540_-	hypothetical protein	NA	NA	NA	NA
WP_020907346.1\|2704623_2705505_+\|head,protease	HK97 family phage prohead protease	Q6JIM8	Burkholderia_virus	4.6e-07	28.9
WP_020907347.1\|2705537_2706632_+\|capsid	phage major capsid protein	X2KQ31	Campylobacter_phage	6.5e-19	29.0
WP_041814936.1\|2706631_2706832_+	hypothetical protein	NA	NA	NA	NA
WP_020907348.1\|2706896_2707487_+	hypothetical protein	NA	NA	NA	NA
WP_041814938.1\|2707549_2707795_+	hypothetical protein	NA	NA	NA	NA
WP_020907350.1\|2707794_2708262_+	hypothetical protein	NA	NA	NA	NA
WP_020907351.1\|2708254_2708728_+	hypothetical protein	NA	NA	NA	NA
WP_158304210.1\|2708732_2708900_+	hypothetical protein	NA	NA	NA	NA
WP_148209199.1\|2708886_2709849_+	hypothetical protein	NA	NA	NA	NA
WP_020907354.1\|2710551_2713260_+	tape measure protein	A0A0A7RUN0	Clostridium_phage	4.1e-06	40.0
WP_020907355.1\|2713259_2714030_+\|tail	phage tail family protein	NA	NA	NA	NA
WP_020907356.1\|2714104_2714512_+	hypothetical protein	A0A0U1UNR7	Pseudomonas_phage	2.8e-28	47.4
WP_020907357.1\|2714523_2717088_+\|tail	phage tail protein	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_007491

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

150830 : 158418

uncultured_Caudovirales_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003944624.1\|150830_151958_-	phosphate ABC transporter substrate-binding protein PstS	M4SNR3	Cyanophage	4.6e-20	28.7
WP_003944613.1\|152189_152882_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_011331629.1\|152878_153550_+	arsenate reductase ArsC	A0A2H4J8A6	uncultured_Caudovirales_phage	8.3e-09	38.5
WP_003944646.1\|153586_153913_+	DUF3349 domain-containing protein	NA	NA	NA	NA
WP_037131620.1\|153937_154321_+	helix-turn-helix transcriptional regulator	A0A218MNF3	uncultured_virus	1.6e-12	53.1
WP_003944591.1\|154317_155406_+	ACR3 family arsenite efflux transporter	NA	NA	NA	NA
WP_003944644.1\|155402_155819_+	arsenate reductase ArsC	A0A2H4PQT9	Staphylococcus_phage	2.0e-13	36.5
WP_003944628.1\|155860_156847_+	thioredoxin-disulfide reductase	A0A2I2L5E1	Orpheovirus	1.2e-75	51.8
WP_003944607.1\|156874_157282_+	low molecular weight phosphatase family protein	A0A2H4PQT9	Staphylococcus_phage	9.8e-13	37.0
WP_003944597.1\|157335_158418_+	NAD(P)/FAD-dependent oxidoreductase	A0A2H4J2Q2	uncultured_Caudovirales_phage	2.9e-59	48.0

DBSCAN-SWA_2

172994 : 257214

Acidithiobacillus_phage(15.38%)

integrase,transposase

attL 172757:172797|attR 243113:243129

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
172757:172797	attL	NA	NA	NA	NA
WP_011331613.1\|172994_173240_+\|transposase	transposase	NA	NA	NA	NA
172757:172797	attL	NA	NA	NA	NA
WP_158304188.1\|174615_174786_+	hypothetical protein	NA	NA	NA	NA
WP_011331611.1\|176206_176335_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_011331610.1\|176371_176563_+	hypothetical protein	NA	NA	NA	NA
WP_011331609.1\|176668_178072_-	triacylglycerol lipase	NA	NA	NA	NA
WP_158304189.1\|180091_180226_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_011331604.1\|180345_180699_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_148209138.1\|180579_181308_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_050768550.1\|182589_182925_-\|transposase	transposase	NA	NA	NA	NA
WP_011331600.1\|183441_183882_-	hypothetical protein	NA	NA	NA	NA
WP_021334707.1\|184570_184738_-	hypothetical protein	NA	NA	NA	NA
WP_011331594.1\|186492_186810_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011331593.1\|186838_188461_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_011331592.1\|188474_189179_-	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	8.4e-36	41.8
WP_011331532.1\|190963_192505_+\|transposase	IS21-like element IS1415 family transposase	NA	NA	NA	NA
WP_011331533.1\|192504_193296_+	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	1.7e-13	27.0
WP_011331585.1\|193910_194222_-\|transposase	transposase	NA	NA	NA	NA
193410:193450	attR	NA	NA	NA	NA
WP_041814210.1\|194345_198236_-	WD40 repeat domain-containing protein	NA	NA	NA	NA
193410:193450	attR	NA	NA	NA	NA
WP_050768544.1\|198314_198671_-\|transposase	transposase	A0A2P1JR32	Mycobacterium_phage	1.4e-18	51.0
WP_011331582.1\|198995_199232_-	DUF2892 domain-containing protein	NA	NA	NA	NA
WP_011331581.1\|199368_201549_+	MMPL family transporter	NA	NA	NA	NA
WP_011331580.1\|201664_201928_+	metal-sensitive transcriptional regulator	NA	NA	NA	NA
WP_011331579.1\|201955_202492_-	hypothetical protein	NA	NA	NA	NA
WP_011331578.1\|202488_203694_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011331577.1\|204278_205673_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_011331576.1\|206257_207046_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_011331575.1\|207074_207413_+	rhodanese-like domain-containing protein	NA	NA	NA	NA
WP_011331574.1\|207414_208257_+	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_011331573.1\|208339_210106_+	cytochrome c oxidase subunit I	R9VX24	Flavobacterium_phage	4.7e-11	39.2
WP_134771772.1\|210102_210603_+	hypothetical protein	NA	NA	NA	NA
WP_148209139.1\|211245_211929_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_011331569.1\|212103_212319_+	DUF2892 domain-containing protein	NA	NA	NA	NA
WP_041814246.1\|212347_213400_-	hypothetical protein	NA	NA	NA	NA
WP_011331567.1\|213517_213925_-	DUF302 domain-containing protein	NA	NA	NA	NA
WP_011331566.1\|214004_214505_-	hypothetical protein	NA	NA	NA	NA
WP_011331565.1\|214610_215345_+	thioredoxin domain-containing protein	NA	NA	NA	NA
WP_011331564.1\|215353_216202_+	thiol-disulfide oxidoreductase	NA	NA	NA	NA
WP_011331563.1\|216192_216540_-	DsrE family protein	NA	NA	NA	NA
WP_011331561.1\|217449_217887_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	S5WIU1	Leptospira_phage	1.7e-07	36.4
WP_011331560.1\|217913_218039_-\|transposase	transposase	NA	NA	NA	NA
WP_011331559.1\|217984_218254_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_134771776.1\|218296_218440_-\|transposase	transposase	NA	NA	NA	NA
WP_011331556.1\|219164_219686_-	PaaI family thioesterase	NA	NA	NA	NA
WP_011331555.1\|219711_221289_-	MFS transporter	NA	NA	NA	NA
WP_011331554.1\|221409_222057_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_011331553.1\|222409_222634_+	hypothetical protein	NA	NA	NA	NA
WP_011331552.1\|223143_223752_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_011331542.1\|229022_229433_+	SCP2 sterol-binding domain-containing protein	NA	NA	NA	NA
WP_030538000.1\|229499_231116_+	fatty acid--CoA ligase	A0A1V0SBX8	Catovirus	9.0e-17	25.8
WP_011331540.1\|231158_232265_+	NDMA-dependent alcohol dehydrogenase	E3SJ82	Synechococcus_phage	9.4e-34	28.3
WP_011331539.1\|232571_233969_+	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_011331538.1\|234318_234639_+	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_021334602.1\|234665_236054_+	cytochrome P450	NA	NA	NA	NA
WP_011331536.1\|236050_237253_+	FAD-dependent oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	5.9e-05	28.4
WP_011331535.1\|237571_238636_+	BtrH N-terminal domain-containing protein	NA	NA	NA	NA
WP_134771775.1\|239003_239495_+	PaaI family thioesterase	NA	NA	NA	NA
WP_011331533.1\|239881_240673_-	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	1.7e-13	27.0
WP_011331532.1\|240672_242214_-\|transposase	IS21-like element IS1415 family transposase	NA	NA	NA	NA
WP_011331529.1\|244685_245915_-\|transposase	IS110 family transposase	A0A1X9I5Z0	Streptococcus_phage	9.3e-06	25.3
WP_011331528.1\|246282_247110_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	8.9e-45	38.2
WP_021334594.1\|247191_247518_+	hypothetical protein	NA	NA	NA	NA
WP_011331526.1\|248243_249557_+\|transposase	ISL3 family transposase	A0A2H4PDF8	Mycobacterium_phage	3.1e-108	48.8
WP_011331525.1\|250205_251351_-	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_021334590.1\|251500_252178_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_021334589.1\|252183_252708_-	PaaI family thioesterase	NA	NA	NA	NA
WP_158304190.1\|252855_253416_+	1-acyl-sn-glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
WP_011331521.1\|253611_254286_-	transglutaminase domain-containing protein	NA	NA	NA	NA
WP_011331520.1\|254282_255365_-	BtrH N-terminal domain-containing protein	NA	NA	NA	NA
WP_050768548.1\|255763_256675_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011331517.1\|256914_257214_+\|transposase	transposase	A0A1B3AZE5	Gordonia_phage	1.8e-24	64.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_012490

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_007491

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection