CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_004606	Streptococcus pyogenes SSI-1, complete genome	1 crisprs	cas3,csn2,cas2,cas1,cas9,csm6,DinG,DEDDh,csa3	0	0	9	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_004606_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_004606_1

1097904-1098005

Orphan

Consensus_repeat	Method
AATAATTGGTATAGTCTAATTATA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_004606_1

>merge|NC_004606|1|1097904-1098005|CRISPRCasFinder
AATAATTGGTATAGTCTAATTATACCGATAAAAACAGTATGTTTACAGTATATAATATCCACAATGTCTTGTCAAACATAAAATTGGTATAGTCTAATTATA

>NC_004606|1|1|1097904-1098005|CRISPRCasFinder
AATAATTGGTATAGTCTAATTATA	CCGATAAAAACAGTATGTTTACAGTATATAATATCCACAATGTCTTGTCAAACA
TAAAATTGGTATAGTCTAATTATA

Protein	Signature genes	Signature genes Name	Protein_function
NC_004606.1\|WP_011054546.1\|1107956_1108145_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|269889
NC_004606.1\|WP_002989648.1\|1086230_1088549_-\|DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|273429
NC_004606.1\|WP_002992407.1\|1089078_1090401_+\|sodium:alanine-symporter-family-protein	unknown	unknown	gnl\|CDD\|224040
NC_004606.1\|WP_002984457.1\|1094120_1094750_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_004606.1\|WP_002989634.1\|1093268_1094105_-\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270217
NC_004606.1\|WP_002984469.1\|1085619_1085868_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NC_004606.1\|WP_011054539.1\|1090520_1091756_+\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131
NC_004606.1\|WP_002984437.1\|1105127_1105826_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_004606.1\|WP_011054544.1\|1100368_1101382_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NC_004606.1\|WP_002988472.1\|1108257_1109040_-\|exotoxin	unknown	unknown	gnl\|CDD\|280949
NC_004606.1\|WP_002984449.1\|1098028_1098586_-\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_004606.1\|WP_011054545.1\|1101461_1104572_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|180917
NC_004606.1\|WP_002989617.1\|1104756_1105128_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224639
NC_004606.1\|WP_011054540.1\|1092125_1092899_-\|CAMP-factor-pore-forming-toxin-Cfa	unknown	unknown	gnl\|CDD\|369335
NC_004606.1\|WP_002984451.1\|1096038_1097853_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_004606.1\|WP_002984433.1\|1105835_1106621_+\|hypothetical-protein	unknown	unknown	unknown
NC_004606.1\|WP_002989626.1\|1095507_1095843_-\|alkylphosphonate-utilization-protein	unknown	unknown	gnl\|CDD\|225380
NC_004606.1\|WP_011054543.1\|1098803_1100306_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235619
NC_004606.1\|WP_011054541.1\|1094759_1095401_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_004606.1\|WP_002989607.1\|1106751_1107366_-\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475

Protein	Function_ID	Function_description	E-value
NC_004606.1\|WP_011054546.1\|1107956_1108145_-\|hypothetical-protein	gnl\|CDD\|269889	cd06603, GH31_GANC_GANAB_alpha, neutral alpha-glucosidase C, neutral alpha-glucosidase AB. This subgroup includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, GANC and GANAB have been shown to have other differences, including those of substrate specificity. GANC and GANAB are key enzymes in glycogen metabolism that hydrolyze terminal, non-reducing 1,4-linked alpha-D-glucose residues from glycogen in the endoplasmic reticulum. The GANC/GANAB family includes the alpha-glucosidase II (ModA) from Dictyostelium discoideum as well as the alpha-glucosidase II (GLS2, or ROT2 - Reversal of TOR2 lethality protein 2) from Saccharomyces cerevisiae.	0.00788697
NC_004606.1\|WP_002989648.1\|1086230_1088549_-\|DNA-helicase-PcrA	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_004606.1\|WP_002992407.1\|1089078_1090401_+\|sodium:alanine-symporter-family-protein	gnl\|CDD\|224040	COG1115, AlsT, Na+/alanine symporter [Amino acid transport and metabolism].	0
NC_004606.1\|WP_002984457.1\|1094120_1094750_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.89978e-111
NC_004606.1\|WP_002989634.1\|1093268_1094105_-\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270217	cd00996, PBP2_AatB_like, Polar amino acids-binding domain of ATP-binding cassette transporter-like systems that belong to the type 2 periplasmic binding fold protein superfamily. This subfamily includes periplasmic binding domain of ATP-binding cassette transporter-like systems that serve as initial receptors in the ABC transport of amino acids and their derivatives in eubacteria. After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically-located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The Abp proteins belong to the PBPI superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.04078e-109
NC_004606.1\|WP_002984469.1\|1085619_1085868_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	1.43969e-13
NC_004606.1\|WP_011054539.1\|1090520_1091756_+\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	6.64721e-96
NC_004606.1\|WP_002984437.1\|1105127_1105826_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	7.28377e-64
NC_004606.1\|WP_011054544.1\|1100368_1101382_-\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	0
NC_004606.1\|WP_002988472.1\|1108257_1109040_-\|exotoxin	gnl\|CDD\|280949	pfam02876, Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain.	1.3915e-23
NC_004606.1\|WP_002984449.1\|1098028_1098586_-\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	2.3728e-38
NC_004606.1\|WP_011054545.1\|1101461_1104572_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|180917	PRK07279, dnaE, DNA polymerase III DnaE; Reviewed.	0
NC_004606.1\|WP_002989617.1\|1104756_1105128_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	4.0536e-49
NC_004606.1\|WP_011054540.1\|1092125_1092899_-\|CAMP-factor-pore-forming-toxin-Cfa	gnl\|CDD\|369335	pfam07373, CAMP_factor, CAMP factor (Cfa). This family consists of several bacterial CAMP factor (Cfa) proteins which seem to be specific to Streptococcus species. The CAMP reaction is a synergistic lysis of erythrocytes by the interaction of an extracellular protein (CAMP factor) produced by some streptococcal species with the Staphylococcus aureus sphingomyelinase C (beta-toxin).	2.69891e-98
NC_004606.1\|WP_002984451.1\|1096038_1097853_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_004606.1\|WP_002989626.1\|1095507_1095843_-\|alkylphosphonate-utilization-protein	gnl\|CDD\|225380	COG2824, PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism].	2.02984e-64
NC_004606.1\|WP_011054543.1\|1098803_1100306_-\|pyruvate-kinase	gnl\|CDD\|235619	PRK05826, PRK05826, pyruvate kinase; Provisional.	0
NC_004606.1\|WP_011054541.1\|1094759_1095401_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	3.51524e-71
NC_004606.1\|WP_002989607.1\|1106751_1107366_-\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	1.14841e-31

>NC_004606.1|WP_002984451.1|1096038_1097853_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQSTEDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKALSIIEGSYAFALMDSQATDTIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELDLSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTPVELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSRESTYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAVGEANGKQEALDFNLVHELSLVAQSIEATLSEKDLVAEKVQALLTTTRNAFYIGRGNDYYVAMEAALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIVNKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE
>NC_004606.1|WP_002989626.1|1095507_1095843_-|alkylphosphonate-utilization-protein
MSLPNCLQCQSEYVYEDGLLLICPMCAFEWTPGEEATEEEGLVVLDSNGVRLSDGDTITVVKDLKVKGAPKDLKQGTRVKNIRLVEGDHNIDCKIDGFGAMKLKSEFVKKI
>NC_004606.1|WP_011054541.1|1094759_1095401_-|amino-acid-ABC-transporter-permease
MTYIQQVLPSLLDGALVTLQVFFIVIILSIPLGAILAFLMKIPFKPLQWFLTLYVWMMRGTPLLLQLIFFYYVLPSVGISFDRMPAAILAFTLNYAAYFAEIFRGGIEAIPKGQYEAAKVLKLKPLQTIRYIILPQVFKIVLPSVFNEVINLVKDSSLVYVLGVGDLLLASKTATNRDATLAPMFIAGLIYLLLIGLVTIISKQVEKRFNYYQ
>NC_004606.1|WP_002984457.1|1094120_1094750_-|amino-acid-ABC-transporter-ATP-binding-protein
MLELKNISKQFGQKTIFDGFNLTVQDGEVLSLVGPSGGGKTTLLRMLAGLESIDSGQVFYNGEDVGIDHLENRNLLGFVFQDFQLFPHLTVLDNLTLSPTITMGKQKADAKEKALDLLARLGLKEHAQVYPYSLSGGQKQRVALARAMMIDPQIIGYDEPTSALDPELRQTVEALIVQNREMGITQIVVTHDLVFAEAISDRIIRVNPK
>NC_004606.1|WP_002989634.1|1093268_1094105_-|amino-acid-ABC-transporter-substrate-binding-protein
MIIKKRTVAILAIASSFFLVACQATKSLKSGDAWGVYQKQKSITVGFDNTFVPMGYKDESGKCKGFDIDLAKEVFHQYGLKVNFQAINWDMKEAELNNGKIDVIWNGYSITKERQDKVAFTDSYMRNEQIIVVKKRSDIKTISDMKHKVLGAQSASSGYDSLLRTPKLLKDFIKNKDANQYETFTQAFIDLKSDRIDGILIDKVYANYYLAKEGQLENYRMIPTTFENEAFSVGLRKEDKTLQAKINRAFRVLYQNGKFQAISEKWFGDDVATANIKS
>NC_004606.1|WP_011054540.1|1092125_1092899_-|CAMP-factor-pore-forming-toxin-Cfa
MKPKHLLCLSTVVAGLALFSTMTHSVLADDASNPDTILMNNNQANFQRDALVQKLDEGHQQLEAIKHEAKGTDIEATVNKAIDAVDHMKSSIRFNTETIYDFSSIGARVEALSDAIKAIVFSTTQLTHKVEKAHTDMGFAITKLVIRIIDPFASVDAIKAQVQEIKALEEKVINYPDLQPTDRATIYTKAKLNKAIWNTRLERDKKVLGIKPFDVYNRLNKAITHAVGVQLNPTTTVQQVDDEVIAVQNALETALKS
>NC_004606.1|WP_011054539.1|1090520_1091756_+|cation-diffusion-facilitator-family-transporter
MTQDPIANLKLARKGPIVSIIVYLLLSVAKLLAGYLLNASSLIADGFNNLSDIVGNVALLIGLHLASQPADANHKFGHWKIEDLSSLVTSFIMFLVGFQVLIHTIKSIFSGQQVDIDPLGAIVGIVSAFVMLGVYVFNKRLSKRVKSSALVAASKDNLADAVTSIGTSIAIIAASLHLPVIDHIAAMIITFFILKTAFDIFMESSFSLSDGFDSRHLKKYEKAILEIPKIVAVKSQRARTYGSNVYLDIVLEMNPDLSVYESHSITEKVEQLLSDQFSIYDIDIHVEPAMIPEEEIFDNVAKKLYRYEKLILSKVPDYDHYIAKSFQLIDANGQTVNYEQFLNQEIYYPSNFNHFQIESISQKTMLVTYQLNGNQRTSIWRRHESWSLLFHQITPIAKRQLHHTHYRIVKM
>NC_004606.1|WP_002992407.1|1089078_1090401_+|sodium:alanine-symporter-family-protein
MIALVKLIDNLVWGPPLLILLVGTGIYLTSRLGLIQILKLPRAFKLIFSDDEGHGDISSFAALATALAATVGTGNIVGVATAIKSGGPGALFWMWVAAFFGMATKYAEGVLAIKYRTKDANGHISGGPMYYIVNGMGTKWKPLAILFAGSGILVALFGIGTFAQVNSITSSLGHSFGLSPQMVSIVLAIFVAAIIFGGIHSISKVAEKVVPFMAIFYILSSLAVIFSHYQQLLPVIRLVFQSAFTPTAAIGGFAGSLMKDAIQKGIARGVFSNESGLGSAPIAAAAAKTNEPVEQGLISMTGTFIDTIIICTLTGLSILVTGQWTGQLEGAPLTQSAFATVFGNLGTFGLTFSLVLFAFTTILGWSYYGERCFEFLFGITHLTYFRIVFVLMVGLGGFLKLELIWVLADIVNGLMALPNLIALLALSPVVILETKHYFIK
>NC_004606.1|WP_002989648.1|1086230_1088549_-|DNA-helicase-PcrA
MNPLLNGMNDRQAQAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKFVNPWNILAITFTNKAAREMKERALALNPATKDTLIATFHSMCVRILRREADHIGYNRNFTIVDPGEQRTLMKRILKQLNIDPKKWNERSILGTISNAKNDLLDEKGYEAQAADMYSQIVARCYKAYQEELRRSEALDFDDLIMMTLRLFDANPDVLAYYQQRYQYIHVDEYQDTNHAQYQLIKLLASRFKNICVVGDADQSIYGWRGADMQNILDFEKDYPDAKVVLLEENYRSTKKILQAANDVINNNRNRRPKKLWTQNADGEQLVYYRANDERDEAVFVASTISNMSQELGKNFKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDLIAYLTIVANPADNISFERIVNEPKRGVGPGTLDKLRQFAYESDQSLLEAASNLLMSPLKGKAAQAIMDLANILGQLRQDLDQMSITDLAEALLEKTGYLDSLRLQNTLESQARIENIEEFLSVTKNFDESSASQEEDETGVDRLGRFLNDLALIADTDDSQAEAAEVTLMTLHAAKGLEFPVVFLIGMEEGVFPLSRASEDPDELEEERRLAYVGITRAEEVLFMTNANTRTLFGKSSYNRPTRFLKEISEELLSYKGLARPAQSSFGVRFSTETHTQFGQGMSLSEALQARKAQAQVRQSAQPMQAHTIPSASTSSVLPFGSNSSVEEVTWQIGDIAHHKKWGDGTVLEVSGSGKTMELKIKFPEVGLKKLLASVAPIEKK
>NC_004606.1|WP_002984469.1|1085619_1085868_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MGLIWTLIVGALIGVIAGALTKKGGSMGWIANIAAGLVGSSVGQALLGSWGPSLAGMSLIPSVIGAVIVVMITSFVLNKTNN
>NC_004606.1|WP_002984449.1|1098028_1098586_-|signal-peptidase-I
MVKRDFIRNILLLLIVIIGAILLRIFVFSTFKVSPETANTYLKSGDLVTIKKNIQPKYKDFVVYRVGKKDYVSRVIAVEGDSVTYMDDIFYLNNMVESQAYLEKMKAHYLNHAPFGTLYTDDFTVATITADKYQKVPKGKYLLLNDNRKNTNDSRRFGLINASQIKGLVTFRVLPLSDFGFVEVE
>NC_004606.1|WP_011054543.1|1098803_1100306_-|pyruvate-kinase
MNKRVKIVATLGPAVEIRGGKKYGEDGYWAGQLDVEESAKKIAELIEAGANVFRFNFSHGDHKEQGDRMATVRLAEEIARQKVGFLLDTKGPEMRTELFADDAKEFSYVTGEKIRVATTQGIQSTRDVIALNVAGSLDIYDEVEVGHTILIDDGKLGLKVIDKDIATRQFIVEVENDGIIAKQKGVNIPNTKIPFPALAERDNADIRFGLEQGLNFIAISFVRTAKDVEEVREICRETGNDHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVFQKMIITKVNAAGKAVITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPVESVRTMATIDRNAQTLLNEYGRLDSSAFPRTNKTDVIASAVKDATHSMDIKLVVTITETGNTARAISKFRPDADILAVTFDEKVQRALMINWAVIPVLAEKPASTDDMFEVAERVAVEAGLVQSGDNIVIVAGVPVGTGGTNTMRVRTVK
>NC_004606.1|WP_011054544.1|1100368_1101382_-|6-phosphofructokinase
MKRIAVLTSGGDAPGMNAAIRAVVRKAISEGMEVYGINRGYAGMVDGDIFPLGSKEVGDKISRGGTFLYSARYPEFAQLEGQLAGIEQLKKHGIEGVVVIGGDGSYHGAMRLTEHGFPAVGIPGTIDNDIAGTDYTIGFDTAVNTAVEAIDKLRDTSSSHGRTFVVEVMGRNAGDIALWAGIASGADQIIVPEEEFDIEKVASTIQYDFEHKGKNHHIIVLAEGVMSGEAFAQKLKEAGDKSDLRVTNLGHILRGGSPTARDRVIASWMGSHAVELLKEGKGGLAVGIHNEELVESPILGTAEEGALFSLTEEGQIIVNNPHKARLDFAALNRSLSQ
>NC_004606.1|WP_011054545.1|1101461_1104572_-|DNA-polymerase-III-subunit-alpha
MFAQLDTKTVYSFMDSLIDLNHYFERAKQFGYHTIGIMDKDNLYGAYHFIKGCQKNGLQPVLGLEVEILYQERQVLLNLIAQNTQGYHQLLKISTAKMSGKLHMDYLCQHLEGIAVIIPSKGWSDTLVVPFDYYIGVDQYTDLSHMDSKRQLIPLRTVRYFAQDDMETLHMLHAIRDNLSLAETPVVESDQELTDCQQLTTFYQTHCPQALQNLEDLVSGIYYDFDTNLKLPHFNRDKSAKQELQELTEAGLKEKGLWKEPYQSRLLHELVIISDMGFDDYFLIVWDLLRFGRSKGYYMGMGRGSAAGSLVAYALNITGIDPVQHDLLFERFLNKERYSMPDIDIDLPDIYRSEFLRYVRNRYGSDHSAQIVTFSTFGPKQAIRDVFKRFGVPEYELTNLTKKIGFKDSLATVYEKSISFRQVINSRTEFQKAFAIAKRIEGNPRQTSIHAAGIVMSDDTLTNHIPLKSGDDMMITQYDAHAIEANGLLKMDFLGLRNLTFVQKMQEKVAKDYGCQIDIAAIDLEDPQTLALFAKGDTKGIFQFEQNGAINLLKRIKPQRFEEIVATTSLNRPGASDYTTNFIKRREGQEKIDLIDPVIAPILEPTYGIMLYQEQVMQIAQIYAGFTLGKADLLRRAMSKKNLQEMQKMEEDFIASAKHLGRAEETARGLFKRMEKFAGYGFNRSHAFAYSALAFQLAYFKAHYPAVFYDIMMNYSSSDYITDALESDFQVAQVTINSIPYTDKIEASKIYMGLKNIKGLPRDFAYWIIEQRPFNSVEDFLTRTPEKYQKKVFLEPLIKIGLFDCFEPNRKKILDNLDGLLVFVNELGSLFSDSSFSWVDAKDYSATEKYSLEQEIVGVGMSKHPLIDIAEKSTQTFTPISQLVKESEAVVLIQIDSIRIIRTKTSGQQMAFLSVNDTKKKLDVTLFPQEYAIYKDQLIEGEFYYLKGRIKERDHRLQMVCQQVQMAISQKYWLLVENHQFDSQISEILGAFPGTTPVVIHYQKNKETIALTKIQVHVTENLKEKLRPFVLKTVFR
>NC_004606.1|WP_002989617.1|1104756_1105128_+|GntR-family-transcriptional-regulator
MSWKFDEKSPIYAQIAQHVMMQIISQEIKSGDQLPTVREYAEIAGVNPNTMQRAFTELEREGMVYSQRTAGRFVTDDQKLIARKRRELAISELESFITNMTKMGFSHTEIIPVLTSFLKEDSQ
>NC_004606.1|WP_002984437.1|1105127_1105826_+|ABC-transporter-ATP-binding-protein
MAHLLQLHHVSKSYREKKAIDDLTITIPNGKIIGLLGPNGSGKTTLIKLINGLLQPNKGEIVIDGYRPCVETKKIISYLPDTTYLNENMRIKDMLEFFSDFYSDFDKSKATSLLRDLELDPEDRFKTLSKGNKEKVQLILVMSRKARLYVLDEPIGGVDPAARDYILKTIINSYCENASVIISTHLISDIEPILDEVIFLKQGRLFLSGNADDLRQEYQQSIDSLFRETYKV
>NC_004606.1|WP_002984433.1|1105835_1106621_+|hypothetical-protein
MFGKLLKYEFRSIGKWYFALNAFVIAIAAILSFTIKLFAQSNSDGLFGVLTNKMLPLTLGLTFGSLIAGSLLSTLLIIIKRFSKSVFGREGYLTLTLPVNSHQIILSKLLASFICSVFNTIILAFAIAIVIVPMFNINELLEGFFNSFKMDYFINMLTVLAYVLLSTFTSILLIYLSISIGQLFSNRRGLMAFIAYFILVILISVAATYVHSHIFNINTSADSFPFTEQKTIYLLILEQFIEMIMFYLATNFIIKNKLNLQ
>NC_004606.1|WP_002989607.1|1106751_1107366_-|TVP38/TMEM64-family-protein
MTKRNSKAYILWQKIIKILGIIALIGTFFLAFWLYRLGILNDSNALKDLVQRYRLWGPFVFIVVQIIQIVFPVIPGGLTTVAGFLIFGPVTGFIYNYVGIIIGSIVLFLLVKTYGRKFILLFVNDKTFYKYERRLETPGYEKLFIFCMASPVSPADIMVMITGLTDMSLKRFVTILLITKPISIIGYSYLFIFGKDVISWFLQH
>NC_004606.1|WP_011054546.1|1107956_1108145_-|hypothetical-protein
MLTYDEFKQAIDDGYIVGDTVMIVRKNGQIFDYVLPHEEARNGEVVTEEKVEEVMVELDYIK
>NC_004606.1|WP_002988472.1|1108257_1109040_-|exotoxin
MNKRIRILVVACVVFCAQLLSISVFASSQPDPTPEQLNKSSQFTGVMGNLRCLYDNHFVEGTNVRSTGQLLQHDLIFPIKDLKLKNYDSVKTEFNSKDLAAKYKNKDVDIFGSNYYYNCYYSEGNSCKNAKKTCMYGGVTEHHRNQIEGKFPNITVKVYEDNENILSFDITTNKKQVTVQELDCKTRKILVSRKNLYEFNNSPYETGYIKFIESSGDSFWYDMMPAPGAIFDQSKYLMLYNDNKTVSSSAIAIEVHLTKK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

30871 : 43260

Synechococcus_phage(28.57%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011106567.1\|30871_34597_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	3.9e-39	26.7
WP_009880323.1\|34830_36285_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.7e-54	32.7
WP_009880322.1\|36312_37335_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FGG1	Synechococcus_phage	2.4e-63	41.7
WP_002986700.1\|37502_38057_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.4e-25	36.1
WP_011054093.1\|38240_39788_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	E3SNU8	Prochlorococcus_phage	3.4e-45	52.4
WP_011054094.1\|39846_40971_-	SH3 domain-containing protein	F8HGP2	Streptococcus_phage	1.3e-06	28.6
WP_032461289.1\|41225_42491_+	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
WP_030127619.1\|42768_43260_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.5e-18	42.3

DBSCAN-SWA_2

428787 : 488414

Streptococcus_phage(78.43%)

integrase,bacteriocin,terminase,holin,head,tRNA,portal,capsid,tail

attL 427772:427788|attR 487309:487325

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
427772:427788	attL	NA	NA	NA	NA
WP_011054912.1\|428787_429714_+\|tRNA	glycine--tRNA ligase subunit alpha	NA	NA	NA	NA
WP_011054911.1\|430080_432120_+\|tRNA	glycine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_002983550.1\|432273_432531_+	DUF896 family protein	NA	NA	NA	NA
WP_011054910.1\|432657_433050_+	PepSY domain-containing protein	NA	NA	NA	NA
WP_011054909.1\|433408_434935_+	glycerol kinase GlpK	NA	NA	NA	NA
WP_011054908.1\|434950_436789_+	type 1 glycerol-3-phosphate oxidase	NA	NA	NA	NA
WP_011054907.1\|436790_437492_+	aquaporin family protein	M1HWZ0	Paramecium_bursaria_Chlorella_virus	1.3e-28	36.8
WP_002994262.1\|437600_438947_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011054905.1\|438936_440436_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_002983569.1\|440561_441206_+	fructose-6-phosphate aldolase	A0A0C5AMY8	Cyanophage	2.2e-43	44.2
WP_011054904.1\|441423_443409_+	transketolase	NA	NA	NA	NA
WP_011054903.1\|443601_443826_+\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_011054902.1\|443901_444636_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	2.2e-26	27.7
WP_011106629.1\|444640_446284_+	hypothetical protein	NA	NA	NA	NA
WP_011054900.1\|446426_447515_-\|integrase	site-specific integrase	Q938N9	Temperate_phage	6.4e-152	72.6
WP_011054899.1\|447690_448242_-	hypothetical protein	A7J267	Streptococcus_phage	1.5e-88	94.0
WP_011054898.1\|448252_448636_-	hypothetical protein	A7J268	Streptococcus_phage	1.5e-68	99.2
WP_011184049.1\|448649_449000_-	helix-turn-helix transcriptional regulator	M1I9X0	Streptococcus_phage	1.2e-48	85.3
WP_001283052.1\|449638_449830_+	hypothetical protein	A7J270	Streptococcus_phage	7.3e-27	100.0
WP_011054896.1\|449850_450081_+	hypothetical protein	A7J271	Streptococcus_phage	3.4e-31	92.0
WP_011054895.1\|450168_450426_+	hypothetical protein	NA	NA	NA	NA
WP_011054894.1\|450454_450625_+	hypothetical protein	A7J273	Streptococcus_phage	9.0e-21	92.9
WP_011054892.1\|450821_451205_+	hypothetical protein	A7J274	Streptococcus_phage	5.9e-60	93.7
WP_011054890.1\|451350_451554_+	hypothetical protein	A7J276	Streptococcus_phage	1.2e-30	94.0
WP_000573833.1\|451641_451941_+	hypothetical protein	A7J277	Streptococcus_phage	2.3e-43	99.0
WP_011054889.1\|451940_453098_+	DUF2800 domain-containing protein	A7J278	Streptococcus_phage	8.5e-219	99.2
WP_011054888.1\|453111_453675_+	DUF2815 family protein	D2J040	Enterococcus_phage	5.6e-51	57.9
WP_011054887.1\|453717_455640_+	DNA polymerase	A7J280	Streptococcus_phage	0.0e+00	98.3
WP_011054886.1\|455644_458029_+	DNA primase	A7J282	Streptococcus_phage	5.7e-286	98.0
WP_011054885.1\|458394_458670_+	VRR-NUC domain-containing protein	A7J283	Streptococcus_phage	2.9e-45	96.7
WP_011054884.1\|458666_459989_+	DEAD/DEAH box helicase family protein	A7J284	Streptococcus_phage	7.3e-251	97.3
WP_011054883.1\|459989_460160_+	hypothetical protein	A7J285	Streptococcus_phage	3.1e-21	94.2
WP_011054882.1\|460152_460425_+	hypothetical protein	A7J287	Streptococcus_phage	5.7e-25	73.3
WP_011054881.1\|460557_460974_+	transcriptional regulator	A7J289	Streptococcus_phage	3.3e-72	99.3
WP_011106637.1\|461063_461516_+\|terminase	terminase small subunit	A7J290	Streptococcus_phage	6.9e-76	100.0
WP_011054879.1\|461505_462783_+\|terminase	PBSX family phage terminase large subunit	A7J291	Streptococcus_phage	1.1e-246	100.0
WP_011106638.1\|462798_464331_+\|portal	phage portal protein	A7J292	Streptococcus_phage	9.9e-292	99.6
WP_011054877.1\|464290_465739_+\|capsid	minor capsid protein	A7J293	Streptococcus_phage	1.3e-277	99.6
WP_011054876.1\|465766_465955_+	hypothetical protein	A7J294	Streptococcus_phage	7.4e-24	100.0
WP_011054875.1\|465959_466226_+	hypothetical protein	Q938K9	Temperate_phage	1.1e-36	95.5
WP_011054874.1\|466393_466963_+	DUF4355 domain-containing protein	A7J296	Streptococcus_phage	7.4e-83	99.5
WP_002983429.1\|466975_467863_+	hypothetical protein	A7J297	Streptococcus_phage	2.1e-161	100.0
WP_011054873.1\|467874_468231_+\|head,tail	phage head-tail connector protein	A7J298	Streptococcus_phage	4.6e-59	100.0
WP_011054872.1\|468241_468520_+	hypothetical protein	A7J299	Streptococcus_phage	1.9e-47	100.0
WP_011106640.1\|468516_468861_+	HK97 gp10 family phage protein	A7J2A0	Streptococcus_phage	5.1e-55	98.2
WP_011054870.1\|468864_469224_+	hypothetical protein	A7J2A1	Streptococcus_phage	1.2e-57	98.3
WP_011054869.1\|469235_469835_+\|tail	phage major tail protein, TP901-1 family	A7J2A2	Streptococcus_phage	1.7e-90	97.1
WP_011054868.1\|469888_470344_+	hypothetical protein	A7J2A3	Streptococcus_phage	3.5e-75	98.0
WP_011054867.1\|470418_470652_+	hypothetical protein	A7J2A4	Streptococcus_phage	6.4e-33	97.4
WP_011054866.1\|470666_475049_+	tape measure protein	A7J2A5	Streptococcus_phage	3.3e-223	75.9
WP_011054865.1\|475060_475903_+	hypothetical protein	A7J2A6	Streptococcus_phage	8.8e-157	97.9
WP_011054864.1\|475912_477892_+\|tail	phage tail protein	A7J2A7	Streptococcus_phage	0.0e+00	92.5
WP_011054441.1\|477888_478896_+	hyaluronoglucosaminidase	Q938K0	Temperate_phage	4.6e-104	61.4
WP_032461307.1\|478905_480921_+	gp58-like family protein	Q938J9	Temperate_phage	3.3e-186	73.4
WP_011106643.1\|480932_481370_+	DUF1617 family protein	Q938J8	Temperate_phage	9.1e-73	98.6
WP_011184056.1\|481366_481984_+	DUF1366 domain-containing protein	Q938J7	Temperate_phage	5.0e-77	89.3
WP_002986916.1\|481993_482266_+	hypothetical protein	A7J2B2	Streptococcus_phage	7.2e-36	91.0
WP_003058873.1\|482262_482490_+\|holin	phage holin	A7J2B3	Streptococcus_phage	2.0e-31	100.0
WP_011184057.1\|482605_483808_+	glucosaminidase domain-containing protein	Q938J4	Temperate_phage	2.8e-241	99.8
WP_023077389.1\|484129_484645_+	hypothetical protein	NA	NA	NA	NA
WP_011106647.1\|484758_485745_-	DNA/RNA non-specific endonuclease	A7J2B8	Streptococcus_phage	1.4e-169	100.0
WP_011054856.1\|485977_486160_+	hypothetical protein	A3F673	Streptococcus_phage	1.5e-21	83.3
WP_011054855.1\|486349_487171_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	4.7e-38	36.8
WP_011054854.1\|487163_488414_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	2.2e-116	55.6
487309:487325	attR	NA	NA	NA	NA

DBSCAN-SWA_3

522777 : 585149

Streptococcus_pyogenes_phage(56.14%)

integrase,holin,tRNA,portal,capsid,tail

attL 543161:543176|attR 557786:557801

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011054834.1\|522777_523713_+\|tRNA	methionyl-tRNA formyltransferase	M4QRX9	Synechococcus_phage	6.0e-05	38.5
WP_002983657.1\|523702_525025_+	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	NA	NA	NA	NA
WP_002983660.1\|525062_525803_+	Stp1/IreP family PP2C-type Ser/Thr phosphatase	NA	NA	NA	NA
WP_002994648.1\|525799_527698_+	Stk1 family PASTA domain-containing Ser/Thr kinase	B5LWE2	Feldmannia_species_virus	1.4e-21	30.7
WP_011054833.1\|527820_528513_+	cell wall-active antibiotics response protein	NA	NA	NA	NA
WP_002991890.1\|528509_529514_+	sensor histidine kinase	NA	NA	NA	NA
WP_002983671.1\|529506_530148_+	response regulator transcription factor	NA	NA	NA	NA
WP_011054832.1\|530184_531585_+	Cof-type HAD-IIB family hydrolase	A0A1V0S9I2	Catovirus	4.1e-26	43.5
WP_002991882.1\|531584_531962_+	S1 RNA-binding domain-containing protein	NA	NA	NA	NA
WP_002991877.1\|531979_532921_-	cysteine synthase A	A0A1X9I5F1	Streptococcus_phage	1.3e-129	77.2
WP_011106658.1\|533048_533681_-	YigZ family protein	A0A1X9I5T8	Streptococcus_phage	5.5e-63	54.3
WP_011054828.1\|535031_535697_+	ComF family protein	NA	NA	NA	NA
WP_002988974.1\|535776_536325_+	ribosome-associated translation inhibitor RaiA	NA	NA	NA	NA
543161:543176	attL	NA	NA	NA	NA
WP_011054826.1\|544098_544632_-	DUF402 domain-containing protein	NA	NA	NA	NA
WP_002991791.1\|544711_545488_-	recombination regulator RecX	NA	NA	NA	NA
WP_009880742.1\|545635_546802_-\|integrase	tyrosine-type recombinase/integrase	C5J953	Streptococcus_phage	7.0e-80	42.2
WP_011054825.1\|547833_547986_-	hypothetical protein	A0A1P8VVQ0	Streptococcus_phage	5.2e-20	100.0
WP_011054824.1\|547996_548374_-	ImmA/IrrE family metallo-endopeptidase	A0A1P8VVK5	Streptococcus_phage	4.0e-69	100.0
WP_011054823.1\|548357_548717_-	helix-turn-helix transcriptional regulator	A0A1P8VVN3	Streptococcus_phage	4.0e-58	97.5
WP_009881062.1\|548905_549124_+	helix-turn-helix transcriptional regulator	A0A1P8VVR5	Streptococcus_phage	4.1e-34	100.0
WP_011054822.1\|549218_549470_+	hypothetical protein	A0A1P8VVV6	Streptococcus_phage	1.4e-41	98.8
WP_011054821.1\|549500_549638_+	hypothetical protein	A0A1P8VVR9	Streptococcus_phage	9.2e-16	91.1
WP_011054583.1\|549653_549968_+	helix-turn-helix transcriptional regulator	A0A1P8VVN6	Streptococcus_phage	2.3e-49	94.2
WP_011054820.1\|550196_550679_+	siphovirus Gp157 family protein	A0A1P8VVS5	Streptococcus_phage	4.6e-78	99.4
WP_002995975.1\|550679_551360_+	AAA family ATPase	A0A1P8VVS4	Streptococcus_phage	1.6e-129	100.0
WP_011054819.1\|551461_552691_+	DEAD/DEAH box helicase	A0A1P8VVM2	Streptococcus_phage	2.8e-236	99.5
WP_011054580.1\|552706_553165_+	DUF669 domain-containing protein	A0A1P8VVN0	Streptococcus_phage	5.0e-82	99.3
WP_011106664.1\|553167_553980_+	bifunctional DNA primase/polymerase	A0A1P8VVM6	Streptococcus_phage	4.6e-155	98.9
WP_011054817.1\|555694_556015_+	VRR-NUC domain-containing protein	A0A1P8VVL5	Streptococcus_phage	5.8e-53	99.1
WP_011054816.1\|555998_556355_+	hypothetical protein	A0A097PAU4	Streptococcus_pyogenes_phage	1.8e-58	94.9
WP_011018137.1\|556596_556881_+	DUF3310 domain-containing protein	A0A1P8VVP5	Streptococcus_phage	2.7e-49	97.9
WP_011054815.1\|556877_557291_+	hypothetical protein	Q938M1	Temperate_phage	1.2e-34	63.1
WP_011054814.1\|557287_557458_+	hypothetical protein	Q938M0	Temperate_phage	2.5e-10	96.8
WP_032461310.1\|557454_557739_+	hypothetical protein	A0A097PAV1	Streptococcus_pyogenes_phage	5.0e-40	91.5
WP_011054813.1\|557741_558077_+	hypothetical protein	A0A097PAS4	Streptococcus_pyogenes_phage	4.7e-45	100.0
557786:557801	attR	NA	NA	NA	NA
WP_011054812.1\|558242_558428_+	hypothetical protein	A0A097PBF0	Streptococcus_pyogenes_phage	7.0e-27	100.0
WP_011054811.1\|558714_559218_+	DUF1642 domain-containing protein	A0A097PAV5	Streptococcus_pyogenes_phage	8.5e-91	97.6
WP_002987493.1\|559214_559385_+	hypothetical protein	A0A097PAS8	Streptococcus_pyogenes_phage	2.9e-27	100.0
WP_011054810.1\|559668_560103_+	ArpU family transcriptional regulator	J7KDQ1	Streptococcus_phage	2.2e-71	94.4
WP_011285571.1\|560712_561093_+	hypothetical protein	A0A097PAR5	Streptococcus_pyogenes_phage	1.0e-64	100.0
WP_032461413.1\|562356_563682_+\|portal	phage portal protein	A0A097PAT2	Streptococcus_pyogenes_phage	1.8e-241	99.5
WP_009880264.1\|563650_564559_+\|capsid	minor capsid protein	A0A097PBF2	Streptococcus_pyogenes_phage	4.2e-88	100.0
WP_011054805.1\|564565_564832_+	hypothetical protein	A0A097PAR8	Streptococcus_pyogenes_phage	2.6e-38	100.0
WP_011054804.1\|564981_565554_+	DUF4355 domain-containing protein	A0A097PAW3	Streptococcus_pyogenes_phage	1.2e-72	100.0
WP_009880261.1\|565571_566462_+	hypothetical protein	A0A097PAW2	Streptococcus_pyogenes_phage	8.6e-86	99.4
WP_009880260.1\|566474_566768_+	Rho termination factor N-terminal domain-containing protein	A0A097PBF3	Streptococcus_pyogenes_phage	2.0e-47	100.0
WP_009880259.1\|566781_567126_+	hypothetical protein	A0A097PAS2	Streptococcus_pyogenes_phage	1.1e-54	100.0
WP_009880258.1\|567122_567434_+	hypothetical protein	A0A097PAW7	Streptococcus_pyogenes_phage	2.6e-50	99.0
WP_009880257.1\|567430_567826_+	hypothetical protein	A0A097PAT9	Streptococcus_pyogenes_phage	1.8e-59	100.0
WP_009880256.1\|567827_568238_+	DUF5072 family protein	A0A097PAW5	Streptococcus_pyogenes_phage	1.4e-70	100.0
WP_009880255.1\|568249_568756_+\|tail	phage major tail protein, TP901-1 family	A0A097PBF4	Streptococcus_pyogenes_phage	2.6e-79	100.0
WP_009880254.1\|568768_569086_+	hypothetical protein	A0A097PAS6	Streptococcus_pyogenes_phage	4.9e-52	100.0
WP_009880253.1\|569058_569517_+	hypothetical protein	A0A097PAX1	Streptococcus_pyogenes_phage	2.3e-82	100.0
WP_011054802.1\|569509_571315_+\|tail	tail protein	A0A097PAU2	Streptococcus_pyogenes_phage	8.8e-263	99.7
WP_009880250.1\|571315_572800_+\|tail	phage tail family protein	A0A097PAW9	Streptococcus_pyogenes_phage	4.3e-292	99.8
WP_011054801.1\|572800_576241_+\|tail	phage tail protein	A0A097PBF5	Streptococcus_pyogenes_phage	0.0e+00	99.9
WP_011106671.1\|576245_578108_+	hypothetical protein	A0A097PAT0	Streptococcus_pyogenes_phage	0.0e+00	99.7
WP_009880247.1\|578118_578466_+	DUF1366 domain-containing protein	A0A097PAX5	Streptococcus_pyogenes_phage	3.5e-59	100.0
WP_011054798.1\|578937_579270_+\|holin	phage holin	A0A097PBF6	Streptococcus_pyogenes_phage	5.7e-51	100.0
WP_011054797.1\|579271_580036_+	CHAP domain-containing protein	A0A097PAT3	Streptococcus_pyogenes_phage	1.5e-150	100.0
WP_011054796.1\|580047_580650_+	hypothetical protein	A0A097PAX9	Streptococcus_pyogenes_phage	7.8e-91	98.8
WP_011054795.1\|580660_581434_+	hypothetical protein	A0A097PAV0	Streptococcus_pyogenes_phage	3.9e-135	100.0
WP_009880241.1\|581443_581665_+	hypothetical protein	A0A097PAX7	Streptococcus_pyogenes_phage	2.5e-18	84.5
WP_009880240.1\|581664_582324_+	hypothetical protein	A0A097PBF7	Streptococcus_pyogenes_phage	8.5e-123	100.0
WP_011054794.1\|582445_583201_-	streptococcal pyrogenic exotoxin SpeA	A0A097PAT7	Streptococcus_pyogenes_phage	2.2e-143	99.6
WP_011054793.1\|583420_583603_+	hypothetical protein	J7KBZ4	Streptococcus_phage	1.1e-19	81.4
WP_002991789.1\|583793_585149_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	1.1e-73	33.0

DBSCAN-SWA_4

615606 : 669296

Temperate_phage(81.54%)

integrase,terminase,tRNA,portal,capsid,tail

attL 624875:624891|attR 644239:644255

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011054774.1\|615606_618255_+\|tRNA	valine--tRNA ligase	A0A1V0S951	Catovirus	7.3e-149	40.1
WP_011054773.1\|618470_619250_-	hypothetical protein	NA	NA	NA	NA
WP_011054772.1\|620259_621219_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_011054771.1\|621310_622243_+	magnesium transporter CorA family protein	NA	NA	NA	NA
WP_002983776.1\|622463_623174_+	thiol-disulfide oxidoreductase-associated membrane protein CcdA2	NA	NA	NA	NA
WP_011054770.1\|623186_623810_+	TlpA family protein disulfide reductase	NA	NA	NA	NA
WP_011054769.1\|623852_624959_+	peptide-methionine (R)-S-oxide reductase MsrB	NA	NA	NA	NA
624875:624891	attL	NA	NA	NA	NA
WP_002986896.1\|625069_626224_-\|integrase	site-specific integrase	Q938N9	Temperate_phage	2.8e-206	100.0
WP_002986895.1\|626342_626864_-	hypothetical protein	Q938N8	Temperate_phage	2.3e-67	100.0
WP_002986894.1\|626874_627255_-	hypothetical protein	Q938N7	Temperate_phage	5.3e-69	100.0
WP_011054768.1\|627268_627628_-	helix-turn-helix transcriptional regulator	Q938N6	Temperate_phage	1.1e-60	100.0
WP_002986891.1\|628423_628615_+	hypothetical protein	A7J270	Streptococcus_phage	1.2e-24	90.5
WP_011054767.1\|628625_629354_+	phage antirepressor KilAC domain-containing protein	Q938N5	Temperate_phage	6.9e-134	100.0
WP_002986888.1\|629386_629536_+	hypothetical protein	Q938N4	Temperate_phage	1.8e-20	100.0
WP_002986887.1\|629532_629733_-	KTSC domain-containing protein	A0A1S5S8T9	Streptococcus_phage	6.3e-21	72.3
WP_011054766.1\|629721_629976_+	hypothetical protein	NA	NA	NA	NA
WP_002988339.1\|630221_630479_+	hypothetical protein	NA	NA	NA	NA
WP_011054765.1\|630507_630693_+	hypothetical protein	Q938N3	Temperate_phage	1.1e-24	100.0
WP_011106684.1\|630786_631044_+	hypothetical protein	A0A1S5SFN6	Streptococcus_phage	1.2e-11	46.4
WP_011054763.1\|631165_631579_+	DnaD domain protein	Q938N2	Temperate_phage	2.1e-63	100.0
WP_011054762.1\|631559_631793_+	hypothetical protein	Q938N1	Temperate_phage	5.0e-38	100.0
WP_011284979.1\|631789_631930_+	hypothetical protein	A0A1X9I6Y1	Streptococcus_phage	7.5e-05	52.3
WP_011054761.1\|631940_632195_+	hypothetical protein	Q938N0	Temperate_phage	7.4e-43	100.0
WP_011018142.1\|632216_632699_+	siphovirus Gp157 family protein	Q938M9	Temperate_phage	8.2e-51	100.0
WP_011054760.1\|632699_633374_+	ERF family protein	Q938M8	Temperate_phage	2.5e-106	100.0
WP_011054759.1\|633366_633786_+	single-stranded DNA-binding protein	Q938M7	Temperate_phage	1.6e-71	100.0
WP_011106686.1\|633791_633995_+	hypothetical protein	Q938M6	Temperate_phage	4.7e-32	100.0
WP_011054758.1\|633994_634435_+	RusA family crossover junction endodeoxyribonuclease	A0A097PAS0	Streptococcus_pyogenes_phage	8.5e-79	97.3
WP_011054757.1\|634431_634788_+	hypothetical protein	A0A1P8VVP9	Streptococcus_phage	1.6e-51	85.6
WP_011054756.1\|634784_635036_+	hypothetical protein	Q938M4	Temperate_phage	6.8e-41	100.0
WP_011054755.1\|635029_635314_+	DUF3310 domain-containing protein	Q938M3	Temperate_phage	5.4e-50	100.0
WP_011054754.1\|635310_635580_+	hypothetical protein	Q938M2	Temperate_phage	4.0e-47	100.0
WP_011054753.1\|635589_635994_+	hypothetical protein	Q938M1	Temperate_phage	6.0e-71	100.0
WP_011054752.1\|635990_636161_+	hypothetical protein	Q938M0	Temperate_phage	4.2e-26	100.0
WP_011054751.1\|636157_636664_+	DUF1642 domain-containing protein	Q938L9	Temperate_phage	9.8e-95	100.0
WP_164997036.1\|636660_636831_+	hypothetical protein	A0A097PAS8	Streptococcus_pyogenes_phage	1.1e-26	98.2
WP_011017866.1\|637104_637545_+	ArpU family transcriptional regulator	Q938L8	Temperate_phage	5.0e-79	100.0
WP_011054748.1\|638183_638441_-	hypothetical protein	NA	NA	NA	NA
WP_002986854.1\|638521_639040_+	ParB N-terminal domain-containing protein	Q938L7	Temperate_phage	1.5e-90	100.0
WP_002986850.1\|639018_639696_+	hypothetical protein	Q938L6	Temperate_phage	8.7e-131	100.0
WP_002986845.1\|639818_640088_+	hypothetical protein	B5SP24	Lactococcus_phage	2.8e-16	51.1
WP_002986841.1\|640148_640526_+	ASCH domain-containing protein	Q938L5	Temperate_phage	1.7e-67	100.0
WP_011054747.1\|640576_641050_+	hypothetical protein	Q938L4	Temperate_phage	4.3e-76	99.4
WP_010922074.1\|641132_642344_+\|terminase	PBSX family phage terminase large subunit	Q938L3	Temperate_phage	3.7e-225	99.7
WP_002986832.1\|642357_643860_+\|portal	phage portal protein	Q938L2	Temperate_phage	5.4e-282	100.0
WP_011054746.1\|643864_645343_+\|capsid	phage minor capsid protein	Q938L1	Temperate_phage	8.2e-275	100.0
644239:644255	attR	NA	NA	NA	NA
WP_002986829.1\|645314_645554_+	hypothetical protein	Q938L0	Temperate_phage	2.8e-36	100.0
WP_011054745.1\|645615_645882_+	hypothetical protein	Q938K9	Temperate_phage	1.5e-38	100.0
WP_011106689.1\|646007_646622_+	hypothetical protein	Q938K8	Temperate_phage	1.3e-96	100.0
WP_010922080.1\|646625_647444_+\|capsid	N4-gp56 family major capsid protein	Q79S85	Temperate_phage	4.0e-146	100.0
WP_011054743.1\|647497_647914_+	hypothetical protein	Q938K7	Temperate_phage	1.1e-56	100.0
WP_010922082.1\|647903_648236_+	hypothetical protein	Q79S86	Temperate_phage	9.6e-59	100.0
WP_010922083.1\|648235_648592_+	hypothetical protein	Q79S88	Temperate_phage	4.5e-62	100.0
WP_010922084.1\|648588_648987_+\|capsid	phage capsid protein	Q79S87	Temperate_phage	3.5e-71	100.0
WP_011054741.1\|648986_649472_+	hypothetical protein	Q938K6	Temperate_phage	1.6e-86	100.0
WP_011054740.1\|649510_649945_+	hypothetical protein	Q938K5	Temperate_phage	2.6e-72	100.0
WP_011054739.1\|649948_650530_+	hypothetical protein	Q938K4	Temperate_phage	1.3e-106	100.0
WP_011054738.1\|650519_653780_+	tape measure protein	Q938K3	Temperate_phage	0.0e+00	99.9
WP_011054737.1\|653776_654493_+\|tail	phage tail family protein	Q938K2	Temperate_phage	2.9e-137	100.0
WP_011054736.1\|654489_656634_+\|tail	phage tail protein	Q938K1	Temperate_phage	0.0e+00	100.0
WP_011054735.1\|656630_657644_+	hyaluronoglucosaminidase	Q938K0	Temperate_phage	1.2e-184	100.0
WP_011054734.1\|657658_659542_+	gp58-like family protein	Q938J9	Temperate_phage	2.8e-256	100.0
WP_002987513.1\|659553_659985_+	DUF1617 family protein	Q938J8	Temperate_phage	1.1e-73	100.0
WP_011054733.1\|659987_660599_+	DUF1366 domain-containing protein	Q938J7	Temperate_phage	2.7e-91	100.0
WP_011054732.1\|660609_660906_+	hypothetical protein	Q938J6	Temperate_phage	7.5e-47	100.0
WP_011054731.1\|660902_661088_+	hypothetical protein	Q938J5	Temperate_phage	1.7e-25	100.0
WP_011054730.1\|661198_662401_+	glucosaminidase domain-containing protein	Q938J4	Temperate_phage	3.3e-242	100.0
WP_011017840.1\|662540_663065_+	DUF4065 domain-containing protein	Q938J3	Temperate_phage	4.0e-99	100.0
WP_011054729.1\|663052_663919_+	DUF334 domain-containing protein	Q938J2	Temperate_phage	3.7e-134	100.0
WP_041174277.1\|664222_665002_+	streptococcal pyrogenic exotoxin SpeK	Q938J1	Temperate_phage	1.6e-144	99.6
WP_011054727.1\|665477_666053_+	hypothetical protein	Q938J0	Temperate_phage	1.7e-111	100.0
WP_011054726.1\|666398_666581_+	hypothetical protein	A3F673	Streptococcus_phage	2.6e-18	76.7
WP_011054725.1\|666825_667566_+	response regulator	Q6XM27	Feldmannia_irregularis_virus	8.0e-05	32.4
WP_011054724.1\|667562_669296_+	sensor histidine kinase	Q9EYF3	Enterobacteria_phage	1.3e-26	33.7

DBSCAN-SWA_5

722302 : 762768

Streptococcus_phage(71.43%)

integrase,terminase,holin,portal,capsid,tail

attL 724911:724930|attR 759311:759330

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_030126969.1\|722302_723154_+	DegV family protein	A0A0N9SI50	Staphylococcus_phage	9.2e-13	35.7
WP_002992620.1\|723146_723989_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_002989129.1\|723966_724554_+	YpmS family protein	NA	NA	NA	NA
WP_002983920.1\|724652_724928_+	HU family DNA-binding protein	A7KV42	Bacillus_phage	2.6e-25	73.0
724911:724930	attL	NA	NA	NA	NA
WP_003051793.1\|725016_726159_-\|integrase	site-specific integrase	M1NRJ9	Streptococcus_phage	2.4e-173	77.4
WP_010922481.1\|726282_726801_-	restriction endonuclease	E8ZDN5	Streptococcus_phage	9.2e-32	45.9
WP_010922480.1\|726812_727568_-	helix-turn-helix transcriptional regulator	A0A1S5S8S8	Streptococcus_phage	2.8e-77	60.8
WP_010922479.1\|727769_727982_+	helix-turn-helix transcriptional regulator	A0A1X9I583	Streptococcus_phage	1.1e-10	56.7
WP_010922478.1\|728251_728563_+	excisionase	A0A1S5SA25	Streptococcus_phage	5.3e-43	77.7
WP_010922477.1\|728564_728750_+	hypothetical protein	Q938N3	Temperate_phage	1.3e-20	83.6
WP_011017564.1\|729253_729640_+	DnaD domain-containing protein	Q938N2	Temperate_phage	8.1e-25	51.9
WP_010922205.1\|729620_729854_+	hypothetical protein	Q938N1	Temperate_phage	2.8e-36	96.1
WP_002988354.1\|729850_729991_+	hypothetical protein	A0A1X9I6Y1	Streptococcus_phage	3.4e-05	54.5
WP_002988357.1\|729999_730206_+	hypothetical protein	NA	NA	NA	NA
WP_011054700.1\|730594_731521_+	recombinase RecT	M1NRN6	Streptococcus_phage	1.2e-90	71.8
WP_000594115.1\|731517_731718_+	hypothetical protein	NA	NA	NA	NA
WP_011054699.1\|731710_732508_+	PD-(D/E)XK nuclease-like domain-containing protein	J7KGZ1	Streptococcus_phage	1.3e-130	83.8
WP_011054698.1\|732872_733268_+	hypothetical protein	A8ATL9	Listeria_phage	1.4e-19	52.3
WP_011054697.1\|733264_734611_+	PcfJ domain-containing protein	A8ATM0	Listeria_phage	1.0e-122	49.4
WP_011054696.1\|734621_734954_+	hypothetical protein	M1NS23	Streptococcus_phage	5.7e-35	66.1
WP_011054695.1\|734950_735463_+	hypothetical protein	M1PFM2	Streptococcus_phage	1.7e-78	85.9
WP_011054694.1\|735498_735816_+	DUF1372 family protein	A1EAD7	Streptococcus_phage	9.0e-30	71.4
WP_011054693.1\|735812_735968_+	hypothetical protein	NA	NA	NA	NA
WP_011054692.1\|735964_736216_+	hypothetical protein	M1PF60	Streptococcus_phage	1.6e-18	59.0
WP_011054691.1\|736291_736711_+	DUF1492 domain-containing protein	A0A1X9I5B5	Streptococcus_phage	1.9e-56	79.1
WP_011054690.1\|736818_737163_+	HNH endonuclease	M1Q0W7	Streptococcus_phage	3.2e-41	69.4
WP_002994106.1\|737310_737667_+	hypothetical protein	M1PRL3	Streptococcus_phage	2.4e-07	57.8
WP_010922468.1\|737663_738932_+\|portal	phage portal protein	M1PFL4	Streptococcus_phage	2.2e-188	75.6
WP_010922467.1\|738924_740418_+	hypothetical protein	M1Q184	Streptococcus_phage	2.0e-87	55.0
WP_002994100.1\|740423_740648_+	hypothetical protein	NA	NA	NA	NA
WP_011054687.1\|740724_740877_+	hypothetical protein	NA	NA	NA	NA
WP_002986828.1\|740869_741136_+	hypothetical protein	Q938K9	Temperate_phage	6.4e-37	95.5
WP_011106704.1\|741137_741353_+	hypothetical protein	M1IRA5	Streptococcus_phage	4.1e-26	72.4
WP_011054685.1\|741434_742850_+\|terminase	terminase	A0A0B5A091	Streptococcus_phage	1.5e-212	74.0
WP_011054684.1\|742930_743392_+	DUF4355 domain-containing protein	M1Q1L0	Streptococcus_phage	1.7e-37	52.6
WP_011054683.1\|743416_744328_+\|capsid	phage major capsid protein	M1PFL0	Streptococcus_phage	2.9e-113	67.0
WP_010922460.1\|744327_744528_+	hypothetical protein	NA	NA	NA	NA
WP_011054682.1\|744537_744960_+	hypothetical protein	A0A0B5A2F6	Streptococcus_phage	8.2e-47	67.2
WP_011054681.1\|744919_745258_+	hypothetical protein	A0A0B5A086	Streptococcus_phage	8.1e-45	75.0
WP_000032787.1\|745250_745487_+	hypothetical protein	A0A1P8BMT2	Lactococcus_phage	2.5e-21	66.7
WP_000573598.1\|745487_745823_+	hypothetical protein	A0A1P8BMR5	Lactococcus_phage	9.8e-35	64.9
WP_011054679.1\|745838_746429_+	hypothetical protein	M1PKG8	Streptococcus_phage	1.1e-60	62.5
WP_010922455.1\|746439_746703_+	hypothetical protein	A0A0B5A2F3	Streptococcus_phage	1.0e-18	55.8
WP_011054678.1\|746717_747089_+	DUF5361 domain-containing protein	M1PL84	Streptococcus_phage	1.7e-35	62.4
WP_011054677.1\|747088_749452_+	hypothetical protein	M1NRG5	Streptococcus_phage	3.6e-131	50.1
WP_002992579.1\|749448_750144_+	hypothetical protein	A0A1B1P761	Bacillus_phage	4.7e-07	32.2
WP_011054676.1\|750125_752099_+\|tail	phage tail protein	M1PKG3	Streptococcus_phage	2.0e-98	49.6
WP_011054675.1\|752098_753208_+	hyaluronoglucosaminidase	A7J2A8	Streptococcus_phage	1.2e-113	65.9
WP_011054674.1\|753222_755004_+	hypothetical protein	Q938J9	Temperate_phage	4.4e-73	41.7
WP_011054673.1\|755012_755444_+	DUF1617 family protein	A3F661	Streptococcus_phage	3.1e-65	91.4
WP_011054672.1\|755446_756061_+	DUF1366 domain-containing protein	Q938J7	Temperate_phage	1.8e-66	79.4
WP_002983475.1\|756071_756527_+\|holin	phage holin family protein	A0A0M4R3G6	Streptococcus_phage	3.0e-63	81.5
WP_002983477.1\|756638_757853_+	glucosaminidase domain-containing protein	A0A1P8VVM5	Streptococcus_phage	9.7e-165	60.5
WP_002983479.1\|758097_758892_+	DNA/RNA non-specific endonuclease	A7J2B8	Streptococcus_phage	8.9e-26	35.6
WP_011054671.1\|758958_759141_+	hypothetical protein	A3F673	Streptococcus_phage	4.4e-21	81.7
WP_011106710.1\|759670_761533_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	2.7e-89	33.8
759311:759330	attR	NA	NA	NA	NA
WP_011054669.1\|761832_762768_-	dihydroorotate oxidase	A0A1V0SH91	Hokovirus	1.0e-65	45.1

DBSCAN-SWA_6

875185 : 922030

Streptococcus_phage(65.38%)

integrase,terminase,holin,head,portal,protease,capsid,tail

attL 863323:863337|attR 886925:886939

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
863323:863337	attL	NA	NA	NA	NA
WP_011054597.1\|875185_877450_+	glycogen/starch/alpha-glucan family phosphorylase	Q8B3H5	Iris_mild_mosaic_virus	1.2e-11	43.7
WP_011054596.1\|877706_878327_-	DUF3862 domain-containing protein	NA	NA	NA	NA
WP_011054595.1\|878689_879778_-\|integrase	site-specific integrase	A0A097PAS9	Streptococcus_pyogenes_phage	4.7e-203	99.2
WP_011106738.1\|879897_880203_-	membrane protein	NA	NA	NA	NA
WP_021340822.1\|880212_881001_-	peptidase S24	A0A1S5SD15	Streptococcus_phage	2.9e-85	62.6
WP_011054593.1\|881372_881519_+	hypothetical protein	A0A097PAP2	Streptococcus_pyogenes_phage	6.6e-20	92.3
WP_011054591.1\|881652_882432_-	hypothetical protein	A0A1S5S7L0	Streptococcus_phage	6.2e-48	57.4
WP_011054590.1\|882488_882695_+	hypothetical protein	A0A097PAQ9	Streptococcus_pyogenes_phage	1.4e-28	92.8
WP_011054589.1\|882683_883070_-	hypothetical protein	A0A097PAT1	Streptococcus_pyogenes_phage	1.2e-65	100.0
WP_011054588.1\|883143_883383_+	helix-turn-helix transcriptional regulator	A0A097PBE6	Streptococcus_pyogenes_phage	4.8e-36	100.0
WP_002984292.1\|883598_883808_-	hypothetical protein	NA	NA	NA	NA
WP_011054586.1\|883958_884198_-	hypothetical protein	NA	NA	NA	NA
WP_011054585.1\|884364_884550_+	helix-turn-helix transcriptional regulator	A0A1X9I6I3	Streptococcus_phage	3.3e-16	72.1
WP_011054584.1\|884627_884924_+	hypothetical protein	A0A097PAT8	Streptococcus_pyogenes_phage	2.1e-49	100.0
WP_011054583.1\|885070_885385_+	helix-turn-helix transcriptional regulator	A0A1P8VVN6	Streptococcus_phage	2.3e-49	94.2
WP_011054820.1\|885613_886096_+	siphovirus Gp157 family protein	A0A1P8VVS5	Streptococcus_phage	4.6e-78	99.4
WP_002995975.1\|886096_886777_+	AAA family ATPase	A0A1P8VVS4	Streptococcus_phage	1.6e-129	100.0
WP_011054819.1\|886878_888108_+	DEAD/DEAH box helicase	A0A1P8VVM2	Streptococcus_phage	2.8e-236	99.5
886925:886939	attR	NA	NA	NA	NA
WP_011054580.1\|888123_888582_+	DUF669 domain-containing protein	A0A1P8VVN0	Streptococcus_phage	5.0e-82	99.3
WP_011106664.1\|888584_889397_+	bifunctional DNA primase/polymerase	A0A1P8VVM6	Streptococcus_phage	4.6e-155	98.9
WP_008087509.1\|891123_891537_+	hypothetical protein	A0A2H4JHE6	uncultured_Caudovirales_phage	2.8e-15	50.0
WP_011054576.1\|891533_891854_+	VRR-NUC domain-containing protein	A0A1P8VVL5	Streptococcus_phage	7.1e-51	94.3
WP_011054575.1\|891837_892041_+	hypothetical protein	A0A1P8VVP9	Streptococcus_phage	3.1e-07	100.0
WP_011106747.1\|892037_892322_+	hypothetical protein	A0A097PAV1	Streptococcus_pyogenes_phage	6.1e-38	87.2
WP_011054573.1\|892911_893313_+	hypothetical protein	NA	NA	NA	NA
WP_011054572.1\|893312_893948_+	SAM-dependent DNA methyltransferase	L0P368	Streptococcus_phage	2.2e-88	68.9
WP_011054571.1\|894220_894661_+	ArpU family transcriptional regulator	Q938L8	Temperate_phage	2.1e-77	98.6
WP_002985375.1\|895246_895585_+	HNH endonuclease	J7KH36	Streptococcus_phage	3.0e-55	90.7
WP_011054569.1\|895756_896224_+\|terminase	phage terminase small subunit P27 family	J7KC46	Streptococcus_phage	3.0e-82	99.4
WP_011054568.1\|896238_897993_+	hypothetical protein	J7KKD1	Streptococcus_phage	0.0e+00	97.3
WP_011054567.1\|897989_898160_+	hypothetical protein	J7KK43	Streptococcus_phage	3.0e-08	58.3
WP_011054566.1\|898152_898419_+	hypothetical protein	Q938K9	Temperate_phage	6.2e-32	86.4
WP_011054565.1\|898452_899673_+\|portal	phage portal protein	J7KDU3	Streptococcus_phage	1.0e-185	81.4
WP_011054564.1\|899650_900316_+\|protease	Clp protease ClpP	M1Q115	Streptococcus_phage	5.4e-93	79.0
WP_011054563.1\|900341_901526_+\|capsid	phage major capsid protein	J7KJ82	Streptococcus_phage	1.2e-180	84.5
WP_011054561.1\|901670_901973_+\|head,tail	phage head-tail connector protein	J7KC36	Streptococcus_phage	1.1e-42	86.7
WP_011054560.1\|901969_902308_+\|head	phage head closure protein	J7KJ42	Streptococcus_phage	8.1e-45	80.0
WP_011054559.1\|902304_902682_+	HK97 gp10 family phage protein	J7KDM3	Streptococcus_phage	2.5e-47	75.2
WP_011054558.1\|902678_903104_+	hypothetical protein	J7KBZ9	Streptococcus_phage	1.7e-68	85.1
WP_011054557.1\|903122_903734_+	hypothetical protein	J7KKC8	Streptococcus_phage	3.8e-77	76.2
WP_011054556.1\|903786_904113_+	hypothetical protein	J7KK85	Streptococcus_phage	1.3e-39	75.9
WP_023609816.1\|904160_904310_+	hypothetical protein	J7KBS0	Streptococcus_phage	5.0e-15	83.7
WP_011054554.1\|904322_908246_+\|tail	phage tail tape measure protein	J7KDT4	Streptococcus_phage	4.6e-240	48.9
WP_011054553.1\|908245_908953_+\|tail	phage tail family protein	Q938K2	Temperate_phage	2.4e-91	69.8
WP_023605202.1\|908949_911097_+\|tail	phage tail protein	Q938K1	Temperate_phage	0.0e+00	93.7
WP_023609821.1\|911096_912206_+	hyaluronidase HylP	A7J2A8	Streptococcus_phage	4.9e-123	71.8
WP_011106754.1\|912215_914234_+	gp58-like family protein	Q938J9	Temperate_phage	4.4e-170	71.6
WP_002983467.1\|914245_914677_+	DUF1617 family protein	Q938J8	Temperate_phage	1.3e-63	89.5
WP_010922094.1\|914679_915297_+	DUF1366 domain-containing protein	Q938J7	Temperate_phage	1.1e-76	88.3
WP_002987582.1\|915306_915582_+	hypothetical protein	A7J2B2	Streptococcus_phage	2.6e-41	100.0
WP_000609113.1\|915578_915806_+\|holin	phage holin	A7J2B3	Streptococcus_phage	5.8e-31	98.7
WP_011054445.1\|915921_917130_+	glucosaminidase domain-containing protein	Q938J4	Temperate_phage	2.9e-214	87.5
WP_011054446.1\|917245_917602_-	hypothetical protein	NA	NA	NA	NA
WP_011054447.1\|917659_917899_-	hypothetical protein	NA	NA	NA	NA
WP_011054448.1\|918162_918414_-	hypothetical protein	A3F666	Streptococcus_phage	2.8e-42	96.4
WP_011054449.1\|918554_918701_-	hypothetical protein	A3F667	Streptococcus_phage	4.0e-17	97.9
WP_011054450.1\|918854_919064_+	helix-turn-helix transcriptional regulator	A3F668	Streptococcus_phage	1.2e-30	100.0
WP_029714017.1\|919262_919445_+	hypothetical protein	A3F673	Streptococcus_phage	1.0e-17	71.7
WP_011054451.1\|920197_922030_+	elongation factor 4	A0A2K9L2P9	Tupanvirus	2.2e-19	41.0

DBSCAN-SWA_7

1074429 : 1147543

Streptococcus_phage(74.07%)

integrase,terminase,holin,tRNA,portal,protease,capsid,tail

attL 1071992:1072007|attR 1147887:1147902

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1071992:1072007	attL	NA	NA	NA	NA
WP_011054534.1\|1074429_1075314_-\|tRNA	tRNA pseudouridine(55) synthase TruB	NA	NA	NA	NA
WP_011054535.1\|1075429_1076770_-	DUF2130 domain-containing protein	NA	NA	NA	NA
WP_011054536.1\|1076866_1077823_-	aromatic acid exporter family protein	NA	NA	NA	NA
WP_002993908.1\|1077833_1078430_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_011054537.1\|1078521_1081158_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_002989664.1\|1081172_1081874_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.9e-36	37.0
WP_002984482.1\|1081991_1082534_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_002984480.1\|1082676_1083318_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_002994467.1\|1083480_1083969_-	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_002984476.1\|1083979_1084180_-	CsbD family protein	J7KJ36	Streptococcus_phage	1.8e-07	50.0
WP_002984475.1\|1084220_1084760_-	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_002984473.1\|1084772_1084961_-	DUF2273 domain-containing protein	NA	NA	NA	NA
WP_011106783.1\|1084971_1085583_-	alkaline shock response membrane anchor protein AmaP	NA	NA	NA	NA
WP_002984469.1\|1085619_1085868_-	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
WP_002989648.1\|1086230_1088549_-	DNA helicase PcrA	A7KV33	Bacillus_phage	3.5e-131	41.2
WP_002992407.1\|1089078_1090401_+	sodium:alanine symporter family protein	NA	NA	NA	NA
WP_011054539.1\|1090520_1091756_+	cation diffusion facilitator family transporter	NA	NA	NA	NA
WP_011054540.1\|1092125_1092899_-	CAMP factor pore-forming toxin Cfa	NA	NA	NA	NA
WP_002989634.1\|1093268_1094105_-	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_002984457.1\|1094120_1094750_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.3e-27	35.5
WP_011054541.1\|1094759_1095401_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_002989626.1\|1095507_1095843_-	alkylphosphonate utilization protein	NA	NA	NA	NA
WP_002984451.1\|1096038_1097853_-	glutamine--fructose-6-phosphate transaminase (isomerizing)	A7IW18	Paramecium_bursaria_Chlorella_virus	5.2e-98	38.9
WP_002984449.1\|1098028_1098586_-	signal peptidase I	NA	NA	NA	NA
WP_011054543.1\|1098803_1100306_-	pyruvate kinase	NA	NA	NA	NA
WP_011054544.1\|1100368_1101382_-	6-phosphofructokinase	NA	NA	NA	NA
WP_011054545.1\|1101461_1104572_-	DNA polymerase III subunit alpha	A0A2L1IZ23	Streptomyces_phage	2.2e-120	29.8
WP_002989617.1\|1104756_1105128_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_002984437.1\|1105127_1105826_+	ABC transporter ATP-binding protein	F2Y2R6	Organic_Lake_phycodnavirus	6.6e-09	27.3
WP_002984433.1\|1105835_1106621_+	hypothetical protein	NA	NA	NA	NA
WP_002989607.1\|1106751_1107366_-	TVP38/TMEM64 family protein	M1Q152	Streptococcus_phage	6.2e-51	52.3
WP_011054546.1\|1107956_1108145_-	hypothetical protein	A3F673	Streptococcus_phage	1.2e-21	84.7
WP_002988472.1\|1108257_1109040_-	exotoxin	A0A097PAT7	Streptococcus_pyogenes_phage	4.3e-49	45.8
WP_011054547.1\|1109252_1110377_-	Fic family protein	D7RWK9	Brochothrix_phage	2.0e-92	48.8
WP_011054548.1\|1110514_1111723_-	glucosaminidase domain-containing protein	Q938J4	Temperate_phage	2.3e-214	87.6
WP_011054444.1\|1111838_1112066_-\|holin	phage holin	A7J2B3	Streptococcus_phage	7.6e-31	98.7
WP_011017397.1\|1112062_1112335_-	hypothetical protein	A7J2B2	Streptococcus_phage	5.5e-36	91.0
WP_011106786.1\|1112346_1112979_-	hypothetical protein	Q938J7	Temperate_phage	4.4e-44	49.0
WP_002988448.1\|1112981_1113410_-	DUF1617 family protein	Q938J8	Temperate_phage	8.1e-58	84.3
WP_011054442.1\|1113421_1115326_-	gp58-like family protein	Q938J9	Temperate_phage	1.5e-212	83.8
WP_041174278.1\|1116338_1118390_-\|tail	phage tail protein	A3F656	Streptococcus_phage	0.0e+00	85.2
WP_011017392.1\|1118386_1119157_-\|tail	phage tail family protein	A3F655	Streptococcus_phage	2.1e-128	87.5
WP_011054439.1\|1119169_1123270_-\|tail	phage tail tape measure protein	A3F654	Streptococcus_phage	0.0e+00	68.4
WP_011017390.1\|1123495_1123798_-	hypothetical protein	A3F652	Streptococcus_phage	1.8e-48	96.0
WP_011017389.1\|1123890_1124475_-\|tail	tail protein	A3F651	Streptococcus_phage	3.1e-92	90.2
WP_011017388.1\|1124486_1124867_-	hypothetical protein	A3F650	Streptococcus_phage	7.4e-63	99.2
WP_011017387.1\|1124859_1125258_-	HK97 gp10 family phage protein	A3F649	Streptococcus_phage	2.9e-70	100.0
WP_011017386.1\|1125259_1125622_-	hypothetical protein	A3F648	Streptococcus_phage	1.1e-60	97.5
WP_011054437.1\|1125614_1125923_-	hypothetical protein	A3F647	Streptococcus_phage	7.8e-47	98.0
WP_011017384.1\|1125922_1126096_-	hypothetical protein	A3F646	Streptococcus_phage	6.4e-22	94.7
WP_011017383.1\|1126109_1127243_-\|capsid	phage major capsid protein	A3F645	Streptococcus_phage	3.2e-202	96.8
WP_011017382.1\|1127259_1128066_-\|protease	Clp protease ClpP	A3F644	Streptococcus_phage	4.6e-147	98.1
WP_011017381.1\|1128046_1129234_-\|portal	phage portal protein	A3F643	Streptococcus_phage	5.6e-218	96.2
WP_032461344.1\|1129386_1129611_-	hypothetical protein	A3F642	Streptococcus_phage	2.0e-36	97.3
WP_011017380.1\|1129601_1131332_-\|terminase	terminase large subunit	A3F641	Streptococcus_phage	0.0e+00	97.0
WP_011017379.1\|1131344_1131662_-\|terminase	P27 family phage terminase small subunit	A3F640	Streptococcus_phage	3.9e-49	99.0
WP_011054436.1\|1131802_1132075_-	HNH endonuclease	A3F639	Streptococcus_phage	4.8e-48	95.6
WP_011017377.1\|1132100_1132487_-	hypothetical protein	A3F638	Streptococcus_phage	1.4e-64	93.0
WP_011017376.1\|1132512_1132716_-	hypothetical protein	NA	NA	NA	NA
WP_011017375.1\|1132773_1133067_-	hypothetical protein	NA	NA	NA	NA
WP_011054435.1\|1133220_1133796_-\|integrase	site-specific integrase	A3F636	Streptococcus_phage	7.4e-107	99.5
WP_011017373.1\|1133955_1134357_-	hypothetical protein	A3F635	Streptococcus_phage	2.7e-71	100.0
WP_011054433.1\|1134371_1135199_-	prohibitin family protein	A3F634	Streptococcus_phage	8.7e-117	99.6
WP_011054432.1\|1135200_1135539_-	helix-turn-helix transcriptional regulator	A3F633	Streptococcus_phage	1.5e-54	92.0
WP_011054431.1\|1135535_1135817_-	hypothetical protein	A3F632	Streptococcus_phage	4.5e-33	92.2
WP_011054429.1\|1135982_1136495_-	DUF1642 domain-containing protein	A0A141E0J6	Streptococcus_phage	4.1e-24	42.5
WP_011054428.1\|1136499_1137132_-	SAM-dependent DNA methyltransferase	L0P368	Streptococcus_phage	3.4e-81	65.7
WP_011054427.1\|1137133_1137418_-	hypothetical protein	A0A097PAV1	Streptococcus_pyogenes_phage	3.6e-38	88.3
WP_011054426.1\|1137414_1137849_-	hypothetical protein	Q938M1	Temperate_phage	6.5e-31	57.3
WP_011054425.1\|1137865_1138072_-	hypothetical protein	NA	NA	NA	NA
WP_011054424.1\|1138085_1138313_-	hypothetical protein	C5J991	Streptococcus_phage	2.7e-12	47.9
WP_011054422.1\|1139124_1139886_-	conserved phage C-terminal domain-containing protein	A0A220GFI5	Streptococcus_phage	1.5e-27	55.3
WP_011106800.1\|1139878_1141234_-	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	9.3e-209	84.7
WP_032461348.1\|1141205_1141394_-	hypothetical protein	NA	NA	NA	NA
WP_011017359.1\|1141514_1141706_-	hypothetical protein	NA	NA	NA	NA
WP_011054421.1\|1141798_1142056_-	hypothetical protein	A3F618	Streptococcus_phage	5.4e-41	98.8
WP_011017357.1\|1142129_1142849_-	ORF6C domain-containing protein	A3F617	Streptococcus_phage	4.6e-106	78.7
WP_011106801.1\|1142890_1143400_+	hypothetical protein	NA	NA	NA	NA
WP_011054420.1\|1143727_1143940_-	helix-turn-helix transcriptional regulator	M1Q1B4	Streptococcus_phage	1.7e-13	52.9
WP_011017354.1\|1143974_1144250_-	hypothetical protein	NA	NA	NA	NA
WP_011017353.1\|1144538_1144889_+	helix-turn-helix transcriptional regulator	A0A1S5SAD3	Streptococcus_phage	1.2e-35	63.5
WP_011017352.1\|1144892_1145285_+	hypothetical protein	A3F612	Streptococcus_phage	2.2e-38	68.7
WP_011017351.1\|1145295_1146036_+	type II toxin-antitoxin system PemK/MazF family toxin	A3F611	Streptococcus_phage	1.6e-130	100.0
WP_011017350.1\|1146346_1147543_+\|integrase	site-specific integrase	A3F610	Streptococcus_phage	3.9e-227	99.0
1147887:1147902	attR	NA	NA	NA	NA

DBSCAN-SWA_8

1291895 : 1302499

Streptococcus_phage(57.14%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011054352.1\|1291895_1293038_-	cysteine desulfurase	A0A1X6WFP1	Pacmanvirus	1.4e-24	27.3
WP_011054351.1\|1293272_1293713_+	membrane protein	NA	NA	NA	NA
WP_002992648.1\|1293742_1295020_+	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_002985132.1\|1295099_1296452_-	glutathione-disulfide reductase	A0A2K5B2C5	Erysipelothrix_phage	4.5e-30	24.0
WP_011054350.1\|1296672_1297014_-	YlbF/YmcA family competence regulator	A0A1X9I5Y8	Streptococcus_phage	1.3e-18	39.3
WP_002985136.1\|1297074_1298241_-	chorismate synthase	A0A291AU41	Pandoravirus	4.5e-34	32.8
WP_002985140.1\|1298334_1299021_-	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	7.0e-88	68.9
WP_011054349.1\|1299017_1300181_-	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	5.8e-143	65.1
WP_011054348.1\|1300288_1302499_+	LTA synthase family protein	W6LM83	Streptococcus_phage	2.9e-268	69.1

DBSCAN-SWA_9

1563822 : 1569856

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011054224.1\|1563822_1564650_+	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	3.8e-128	79.5
WP_002995120.1\|1564723_1565080_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	2.8e-40	66.7
WP_011054223.1\|1565377_1566007_+	copper homeostasis protein CutC	NA	NA	NA	NA
WP_002985833.1\|1566053_1566446_-	hypothetical protein	NA	NA	NA	NA
WP_011054222.1\|1566472_1567336_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	1.9e-114	74.7
WP_011054221.1\|1567340_1567664_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	1.0e-28	62.3
WP_011054220.1\|1568327_1569203_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	1.5e-71	47.6
WP_011054219.1\|1569220_1569856_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.7e-65	63.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage