CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_002952	Staphylococcus aureus subsp. aureus MRSA252, complete genome	8 crisprs	csa3,cas3,DEDDh,DinG,WYL	5	0	12	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_002952_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002952_1

848931-849015

Unclear

Consensus_repeat	Method
CACCCCAACTTGCATTGTCTGTAGAA	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NC_002952_1

>merge|NC_002952|1|848931-849015|CRISPRCasFinder
CACCCCAACTTGCATTGTCTGTAGAAATTGGGAATCCAATTTCTCTTTGTTGGGGCCCACACCCCAACTTGCATTGCCTGTAGAA

>NC_002952|1|1|848931-849015|CRISPRCasFinder
CACCCCAACTTGCATTGTCTGTAGAA	ATTGGGAATCCAATTTCTCTTTGTTGGGGCCCA
CACCCCAACTTGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_002952.2\|WP_000617735.1\|843812_844385_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NC_002952.2\|WP_000057557.1\|859419_860859_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NC_002952.2\|WP_000749385.1\|849523_850363_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NC_002952.2\|WP_000460983.1\|837380_838451_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_002952.2\|WP_010956597.1\|847644_848755_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NC_002952.2\|WP_000370984.1\|842002_843085_+\|DEAD/DEAH-box-helicase	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|226583
NC_002952.2\|WP_000686342.1\|840772_841639_+\|DegV-family-protein	unknown	unknown	gnl\|CDD\|273257
NC_002952.2\|WP_000258151.1\|838768_839824_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NC_002952.2\|WP_000192947.1\|839987_840629_-\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|224653
NC_002952.2\|WP_000662687.1\|853681_856528_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_002952.2\|WP_000538140.1\|850536_851187_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NC_002952.2\|WP_001224791.1\|858926_859412_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NC_002952.2\|WP_000134960.1\|860925_861861_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NC_002952.2\|WP_001791369.1\|847371_847470_+\|hypothetical-protein	unknown	unknown	unknown
NC_002952.2\|WP_000506536.1\|844798_847330_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NC_002952.2\|WP_000958224.1\|857138_858071_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NC_002952.2\|WP_000508984.1\|858076_858919_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NC_002952.2\|WP_000229253.1\|851688_853674_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_002952.2\|WP_000638419.1\|851183_851420_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234
NC_002952.2\|WP_001057973.1\|843077_843752_+\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970

Protein	Function_ID	Function_description	E-value
NC_002952.2\|WP_000617735.1\|843812_844385_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.13584e-37
NC_002952.2\|WP_000057557.1\|859419_860859_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	7.77476e-06
NC_002952.2\|WP_000749385.1\|849523_850363_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	3.29354e-42
NC_002952.2\|WP_000460983.1\|837380_838451_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.2404e-45
NC_002952.2\|WP_010956597.1\|847644_848755_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_002952.2\|WP_000370984.1\|842002_843085_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|226583	COG4098, comFA, Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair].	1.30855e-179
NC_002952.2\|WP_000686342.1\|840772_841639_+\|DegV-family-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	9.17692e-120
NC_002952.2\|WP_000258151.1\|838768_839824_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	2.69988e-87
NC_002952.2\|WP_000638419.1\|851183_851420_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
NC_002952.2\|WP_000662687.1\|853681_856528_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_002952.2\|WP_000538140.1\|850536_851187_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	4.12313e-58
NC_002952.2\|WP_001224791.1\|858926_859412_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	7.57447e-30
NC_002952.2\|WP_000134960.1\|860925_861861_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	5.52692e-153
NC_002952.2\|WP_000192947.1\|839987_840629_-\|YigZ-family-protein	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	7.46066e-72
NC_002952.2\|WP_000506536.1\|844798_847330_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NC_002952.2\|WP_000958224.1\|857138_858071_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NC_002952.2\|WP_000508984.1\|858076_858919_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	6.12313e-120
NC_002952.2\|WP_000229253.1\|851688_853674_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_002952.2\|WP_001057973.1\|843077_843752_+\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	1.20522e-50

>NC_002952.2|WP_010956597.1|847644_848755_+|peptide-chain-release-factor-2
MELSEIKRNIDKYNQDLTQIRGSLDLENKETNIQEYEEMMAEPNFWDNQTKAQDIIDKNNALKAIVNGYKTLQAEVDDMDATWDLLQEEFDGEMKEDLEQEVINFKAKVDEYELQLLLDGPHDANNAILELHPGAGGTESQDWANMLFRMYQRYCEKKGFKVKTVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPDFNNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPSGIVVNNQNERSQIKNREAAMKMLKSKLYQLKLEEQAREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGDIGPFIESYLRQTMSHD
>NC_002952.2|WP_001791369.1|847371_847470_+|hypothetical-protein
MLWEESFYFTSVKYFKKCEEVVKRCYVLSLKK
>NC_002952.2|WP_000506536.1|844798_847330_+|preprotein-translocase-subunit-SecA
MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQNDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPTYLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITYSTNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKQDEDYKYDEKTKSVHLTEQGADKAERMFKVENLYDVQNVDVISHINTALRAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMASITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGKFDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGAGQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGDSRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARKRILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQPFIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILLRSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILKSVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNCHGK
>NC_002952.2|WP_000617735.1|843812_844385_+|ribosome-associated-translation-inhibitor-RaiA
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ
>NC_002952.2|WP_001057973.1|843077_843752_+|ComF-family-protein
MNNCLSCGAKLYENITIYNLFKKPNRLCDRCKENWDNIKLDIKARRCSRCLKYLDQNEAYCLDCKFLSAHFNLMEQLYCQFQYDGLMKEMIHQYKFSKDYYLCELLAHLIEIPQTSYDYIVPIPSSPAHDLSRTFNPVEAVLKAKGIRFDKILKMSNRPKQSHLTKKERLADENPFIIDTELDLNGKEILLVDDIYTTGLTIHRAGCKLYAKNIRKFKVFAFAR
>NC_002952.2|WP_000370984.1|842002_843085_+|DEAD/DEAH-box-helicase
MDNVTRYKITESSQSSSQAYYHLSFELSEQQSYASEHIVRAIRMRQTILLYAVTGAGKTEMMFQGIQYARRQGDNIAIVSPRVDVVVEISKRIKDAFLNEDIDILHQQSSQQFEGHFVVCTVHQLYRFKQHFDTIFIDEVDAFPLSMDKSLQQALKSSSKVEHATIYMTATPPKQLLSEIPLENIIKLPARFHKKSLPVPKYRYFKLNNNKIQKMLYRILQDQINNQRYTLVFFNNIETMIKTFSIYKQKITKLTYVHSEDVFRFEKVEQLRNGQYDVIFTTTILERGFTMANLDVVVIDAHQYTQEALIQIAGRVGRKLECPTGKVLFFHEGVSMNMIQAKKEIQKMNKLALKRGWIDE
>NC_002952.2|WP_000686342.1|840772_841639_+|DegV-family-protein
MKIAVMTDSTSYLSQDLIDKYNIQIAPLSVTFDDGKNFTESNEIAIEEFYNKMASSQTIPTTSQPAIGEWITKYEMLRDQGYTDIIVICLSSGISGSYQSSYQAGEMVEGVNVHAFDSKLAAMIEGCYVLRAIEMVEEGYEPQQIIDDLTNMREHTGAYLIVDDLKNLQKSGRITGAQAWVGTLLKMKPVLKFEDGKIIPEEKVRTKKRAIQTLEKKVLDIVKDFEEVTLFVINGDHFEDGQALYKKLQDDCPSAYQVAYSEFGPVVAAHLGSGGLGLGYVGRKIRLT
>NC_002952.2|WP_000192947.1|839987_840629_-|YigZ-family-protein
MTQNIITVKKEHIIENVISKSRFIAHIKPVQNEDEAKAFIAAIKKEHKDATHNCSAYTIGPEMNIQKANDDGEPTGTAGVPMLDILKKLDVHNACVVVTRYFGGIKLGGGGLIRAYSGAVRDVIYDIGRVELREAVPCIVTLNYDQTGKFEYELASTHFMLRNQTYTDKVSYYIDVVKSDYEAFINFLNQMTAGNFDLTEETPKQLPFDIPTE
>NC_002952.2|WP_000258151.1|838768_839824_+|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MVTLLLVAVTMIVSLTITPIVIAISKRLNLVDKPNFRKVHTKPISVMGGTVILFSFLIGIWIGHPIETEIKPLIIGAIIMYVLGLVDDIYDLKPYIKLAGQIAAALVVAFYGVTIDFISLPMGTTIHFGFLSIPITVIWIVAITNAINLIDGLDGLASGVSAIGLITIGFIAILQANIFITMICCVLLGSLIGFLFYNFHPAKIFLGDSGALMIGFIIGFLSLLGFKNITIIALFFPIVILAVPFIDTLFAMIRRVKKGQHIMQADKSHLHHKLLALGYTHRQTVLLIYSISILFSLSSIILYVSPPLGVVLMFVLIIFSIELIVEFTGLIDNNYRPILNLISRKSSHKEE
>NC_002952.2|WP_000460983.1|837380_838451_-|GGDEF-domain-containing-protein
MFEAFIYNISVIVAGIYLFHRLQYSENKRMVFSKAYVTVLMTIVSLLLSVYPIPYREDYLIHLTFVPLLFLGRFTNMVYTLSATVIVAIVEIVVFNNSIMYGVTLIVIAAVTSAIGPFLKQNDVLSLLILNVVTIIILFGVALVSPIYTLSEVIILIPISLIITLASAITFVDIWHFFSLVNRYENEDKYDYLTGLGNVKEFDRHLNEISRKAEKEHQSIALLLIDIDGFKDVNDTYSHKSGDAVLKQMSQLLKNYVPNQFKIFRNGGEEFSVVIHNYSLDQSVKLAENIRSGVEKSSFHLPNKEVIKLSVSIGVGYLTDDDPKSQRKVFKDADDMVHVAKNQGRNKVMFNPIINL
>NC_002952.2|WP_000749385.1|849523_850363_+|CHAP-domain-containing-protein
MKKSLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKTVKSPVRKASQAKKVVQQPVQQASKKVVVKQAPKQTVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>NC_002952.2|WP_000538140.1|850536_851187_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKGKEENE
>NC_002952.2|WP_000638419.1|851183_851420_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NC_002952.2|WP_000229253.1|851688_853674_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NC_002952.2|WP_000662687.1|853681_856528_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNINLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>NC_002952.2|WP_000958224.1|857138_858071_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NC_002952.2|WP_000508984.1|858076_858919_+|prolipoprotein-diacylglyceryl-transferase
MGGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPGEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTRKVK
>NC_002952.2|WP_001224791.1|858926_859412_+|acetyltransferase
MRKFLSKEYHRTNPLWHVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQILNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NC_002952.2|WP_000057557.1|859419_860859_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMANQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLKEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVSENDLMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NC_002952.2|WP_000134960.1|860925_861861_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSAPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA

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Click the colored protein region to show detailed information

Crispr_ID: NC_002952_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002952_2

907335-907414

Orphan

Consensus_repeat	Method
CCGTCAGCTTCTGTGTTGGGGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_002952_2

>merge|NC_002952|2|907335-907414|CRISPRCasFinder
CCGTCAGCTTCTGTGTTGGGGCCCACCCCAACTTGCATTGCTTGTAAGCTGACTTTCCGTCAGCTTCTATGTTGGGGCCC

>NC_002952|2|2|907335-907414|CRISPRCasFinder
CCGTCAGCTTCTGTGTTGGGGCCC	ACCCCAACTTGCATTGCTTGTAAGCTGACTTT
CCGTCAGCTTCTATGTTGGGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_002952.2\|WP_000422908.1\|903977_904517_+\|nitroreductase	unknown	unknown	gnl\|CDD\|380312
NC_002952.2\|WP_000150036.1\|903178_903895_+\|type-I-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|184156
NC_002952.2\|WP_001147955.1\|904666_904987_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_002952.2\|WP_000520233.1\|909614_910310_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NC_002952.2\|WP_000205572.1\|914430_915738_+\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NC_002952.2\|WP_001798062.1\|906202_907081_+\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|226395
NC_002952.2\|WP_001018965.1\|907671_908058_+\|topiosmerase	unknown	unknown	gnl\|CDD\|224572
NC_002952.2\|WP_001183862.1\|912392_913244_-\|DUF368-domain-containing-protein	unknown	unknown	gnl\|CDD\|224946
NC_002952.2\|WP_000569884.1\|901715_902210_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|372596
NC_002952.2\|WP_000255545.1\|900942_901560_-\|amino-acid-transporter	unknown	unknown	gnl\|CDD\|224198
NC_002952.2\|WP_000571209.1\|908596_909622_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224058
NC_002952.2\|WP_000752917.1\|911964_912159_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
NC_002952.2\|WP_000974455.1\|902608_903031_-\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649
NC_002952.2\|WP_001140696.1\|900288_900870_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NC_002952.2\|WP_001006454.1\|915843_917094_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NC_002952.2\|WP_000168845.1\|913571_914333_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NC_002952.2\|WP_000589549.1\|905130_905487_+\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239334
NC_002952.2\|WP_000732338.1\|910327_911149_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NC_002952.2\|WP_000290491.1\|905644_906025_+\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NC_002952.2\|WP_001065806.1\|908050_908347_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245

Protein	Function_ID	Function_description	E-value
NC_002952.2\|WP_000422908.1\|903977_904517_+\|nitroreductase	gnl\|CDD\|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	2.10032e-49
NC_002952.2\|WP_000150036.1\|903178_903895_+\|type-I-3-dehydroquinate-dehydratase	gnl\|CDD\|184156	PRK13575, PRK13575, type I 3-dehydroquinate dehydratase.	6.29269e-147
NC_002952.2\|WP_001147955.1\|904666_904987_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	3.63533e-24
NC_002952.2\|WP_000520233.1\|909614_910310_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	9.67625e-100
NC_002952.2\|WP_000205572.1\|914430_915738_+\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	8.11734e-136
NC_002952.2\|WP_001798062.1\|906202_907081_+\|DUF1963-domain-containing-protein	gnl\|CDD\|226395	COG3878, COG3878, Uncharacterized protein conserved in bacteria [Function unknown].	1.81941e-75
NC_002952.2\|WP_001018965.1\|907671_908058_+\|topiosmerase	gnl\|CDD\|224572	COG1658, COG1658, Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair].	1.24029e-35
NC_002952.2\|WP_001183862.1\|912392_913244_-\|DUF368-domain-containing-protein	gnl\|CDD\|224946	COG2035, COG2035, Predicted membrane protein [Function unknown].	1.10175e-76
NC_002952.2\|WP_000569884.1\|901715_902210_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|372596	pfam13420, Acetyltransf_4, Acetyltransferase (GNAT) domain.	2.53639e-47
NC_002952.2\|WP_000255545.1\|900942_901560_-\|amino-acid-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	5.25608e-61
NC_002952.2\|WP_000571209.1\|908596_909622_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	2.26346e-169
NC_002952.2\|WP_000752917.1\|911964_912159_+\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	5.95583e-07
NC_002952.2\|WP_000974455.1\|902608_903031_-\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	1.40241e-61
NC_002952.2\|WP_001140696.1\|900288_900870_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	1.48716e-48
NC_002952.2\|WP_001006454.1\|915843_917094_+\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NC_002952.2\|WP_000168845.1\|913571_914333_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	1.29081e-150
NC_002952.2\|WP_000589549.1\|905130_905487_+\|arsenate-reductase-family-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	1.06191e-56
NC_002952.2\|WP_000732338.1\|910327_911149_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	5.3847e-113
NC_002952.2\|WP_000290491.1\|905644_906025_+\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	9.01516e-70
NC_002952.2\|WP_001065806.1\|908050_908347_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	5.59534e-14

>NC_002952.2|WP_001798062.1|906202_907081_+|DUF1963-domain-containing-protein
MLNIQDVSHLSKKEQKAYNRFVESVENGNLPVLPCIEMDLKEMQEETLNQSKIGGMPFLKSFKDIPLDENNVPMVLLAQINLNDLPEQQELFPVNEGILQFWISSEDQMYGMSENLKGNNINSRLVYIKEPITDLSLKDIQAHLKSLDADNEDIPFSGAFSIEFRLSKQTITCTDYKYDEDDLALWNKVNPSFALKSMFGGYDELMEPVCNTFTAKEPFNQLGGYPYFDQIDPRTNDQELKMYDRVLLQIDSTRDGNSSIIWGDLGIANILVKSTDLEAMKFDDYMYSWDCS
>NC_002952.2|WP_000290491.1|905644_906025_+|glycine-cleavage-system-protein-GcvH
MAVPNELKYSKEHEWVKVEGNVATIGITEYAQSELGDIVFVELPETDDEINEGDTFGSVESVKTVSELYAPISGKVVEVNEELEDSPEFVNESPYEKAWMVKVEISDESQLEALLTAEKYSEMIGE
>NC_002952.2|WP_000589549.1|905130_905487_+|arsenate-reductase-family-protein
MIKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTGVEINKLFNTHGAKYRELDLKNKLQTLSDDEKLELLSSDGMLVKRPLAVMGDKITLGFKEDQYKETWLA
>NC_002952.2|WP_001147955.1|904666_904987_-|thioredoxin-family-protein
MQAIKSNESFKSVINSDTPVIVKFEAGWCPDCRAMDLWIDPIVEQYNDYQWYTVNRDELEDVVVENEVMGIPSLLVFKNGDKIAHLHSANAKSPEQVESFLAETFK
>NC_002952.2|WP_000422908.1|903977_904517_+|nitroreductase
MELQQAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFAFPNELDKQQCHYDAVTKLGGMLLLILKTDPRQRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYLTDLEEDMPKAPRKNRNLITLY
>NC_002952.2|WP_000150036.1|903178_903895_+|type-I-3-dehydroquinate-dehydratase
MTHVEVVATITPQLYIEETLIQKINHRIDAIDVLELRIDQFENVTVDQVAEMITKLKVMQDSFKLLVTYRTKLQGGYGQFTNDSYLNLISDLANINGIDMIDIEWQADIDIEKHQRIITHLQQYNKEVIISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMSTFSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGEPQAPGQIDVTDLKAQVTLY
>NC_002952.2|WP_000974455.1|902608_903031_-|organic-hydroperoxide-resistance-protein
MAIHYETKATNVGGRKGHVYTDDRALDIDIVPPAQADGKATNPEQLFAAGYASCFNGAFDLILKQNKVRDAHPEVTLTVRLEDDPDSESPKLSVSIDATIKNVISQEEAEKYLQMAHEFCPYSKATQGNINVDLNVNVVD
>NC_002952.2|WP_000569884.1|901715_902210_-|GNAT-family-N-acetyltransferase
MIEIKTLTNNDFNEYKRLVSTVNEEFTQDSHYSQTMTDTLIHDILNQGSPKCIVFGCYENETLIATAALEQIRYVGKEHKSLIKYNFVTNNDKSINSELINFIINYARQNNYESLLTSIVSNNIGAKVFYSALGFDILGFEKNAIKIGNTYFDEHWLFYDLINK
>NC_002952.2|WP_000255545.1|900942_901560_-|amino-acid-transporter
MVTAIIHGFILAIGLILPLGAQNVFIFNQGANQPKYRYVLPAIITAGLSDSLFIIIAVVGVSIIIMSLPILQAIIYIVGLIFLMYMAWTIWHDKPSTDGEAQIMSPMKQVSFALSVSLLNPHAILDTIGVIGSSAALYSGSNKIAFTIACISVSWLWFFLLAILGKMVGSIDKTGKLLTIINKISSIIIIIVALMILQKLIQLLF
>NC_002952.2|WP_001140696.1|900288_900870_+|histidine-phosphatase-family-protein
MAKTLYLMRHGQTLFNFKGLIQGFGDSPLTELGIAQAQKARSYYETKGINFDLYASSTQERASDTLENVAPNQSYQRFKGLKEWHFGLFEGESVYLFDNLYKPEDLFGDRIVPFKGEARQQVEDRIVKTLHDIMSQTKNNALVVSHGTIMGVFLRYCLKLDEALKHNIGNCNILKFEYDNGTFKFVELIDPNL
>NC_002952.2|WP_001018965.1|907671_908058_+|topiosmerase
MAIVNKVIIVEGKSDKKRVQQVIAEPVNIICTHGTMSIDKLDDMIESLYDKQVFVLADSNDEGDRIRNWFKRYLSESEHIFIDKTYCQVANCPKQYLAHVLSKHGFTCKKETPFLPNINNERLVLVNE
>NC_002952.2|WP_001065806.1|908050_908347_+|thioredoxin-family-protein
MNNSLDIKDVTTFYEEGKHLIYGYTPTCGTCKVSERMLDITNEILQLPLLKIDLNFYPQFCKDMQIMSTPILLLMNKDKEVKRIYAFQSVTDLLENLK
>NC_002952.2|WP_000571209.1|908596_909622_+|methionine-ABC-transporter-ATP-binding-protein
MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIILITHEMHVIRRICDEVAVMESGKVIEHGPVTQVFENPQHAVTKRFVKEDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSIDFGKFEKELIERQVKMEVLRHG
>NC_002952.2|WP_000520233.1|909614_910310_+|ABC-transporter-permease
MGKSFSEIINEMITMPNIQWPEVWTAIVETLYMTVVSTIFAFILGLILGVLLFLSAKGKSIGARLFYSIVSFIVNLFRAIPFIILILLLIPFTSLILGTISGPTGALPALIIGAAPFYARLVEIAFKEIDKGVIEAAWSMGANTWTVIRKVLLPEAMPALVSGITVTAIALVGSTAVAGVIGAGGLGNLAYLTGFTRNQNDVILVSTVFILIIVFIIQFIGDWLTNKLDKR
>NC_002952.2|WP_000732338.1|910327_911149_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKLFGLILVLTFAVVLAACGNGSKSGSDDKKITVGASPAPHAEILEKAKPLLEKKGYELDIKTINDYTTPNKLLDKGEIDANYFQHTPYLNTEKKDKGYKIVSAGNVHLEPMAVYSKKYKSLKELPKGATVYVSNNPAEQGRFLKFFVDAGLIKIKKGVKIEDAKFSDITENKKDIKFNNKQSAEFLPKIYQNEDADAVIINSNFAIEQKLNPKKDSIAVESAKDNPYANLIAVKEGHQDDKKIKALIEVLQSKDIQDFINEKYNGAVIPAK
>NC_002952.2|WP_000752917.1|911964_912159_+|CsbD-family-protein
MADESKFEQAKGNVKETVGNVTDNKNLENEGKEDKASGKAKEFVENAKEKATDFIDKVKGNKGE
>NC_002952.2|WP_001183862.1|912392_913244_-|DUF368-domain-containing-protein
MQQFKWINILKGFAMGTSDLVPGVSGGTIALLLGIYNQFIASISGIFSRRFWPSFTFLIPIIIGMLLAMGSLSNLFNYLLSQHHIPTMFFFGGLIIGIVPYLLKISNYKTSFTTKHYMMVIAGIAILIVITLMNNSDKHAGETLTLSTGLIIKYFIAGMCASSAMLLPGISGSFMLLVFGVYGTVMLAISEVVKLNFAGLPILLAVGFGVLAGFIISSKIIQYFLTHHKLMTFALIIGFVVGSLFAVFPGLPTNIVMWFVSLVVFIIGFIVSLTLGRITAENE
>NC_002952.2|WP_000168845.1|913571_914333_+|Fe-S-cluster-assembly-ATPase-SufC
MASTLEIKDLHVSIEDKEILKGVNLTINTDEIHAIMGPNGTGKSTLSSAIMGHPSYEVTKGEVLLDGVNILELEVDERAKAGLFLAMQYPSEITGVTNADFMRSAINAKREEGQEINLMQFIKKLDKNMDFLDIDKDMAQRYLNEGFSGGEKKRNEILQLMMLEPKFAILDEIDSGLDIDALKVVSKGINQMRGENFGALMITHYQRLLNYITPDKVHVMYAGKVVKSGGPELAKRLEEEGYEWVKEEFGSAE
>NC_002952.2|WP_000205572.1|914430_915738_+|Fe-S-cluster-assembly-protein-SufD
MTTDILNISEEQLVDYSKAHNEPSWMTELRKKALKLTETLEMPKPDKTKLRKWDFDSFKQHDVKGDVYQSLSQLPESVREIIDVDHSKNLVIQHNNTIAYTQVDDNASKDGVIVEGLADALMNHSDLVQKYFMKDAVTVDEHRITALHTALVNGGVFVYVPKNVVVEHPVQYVVLHDDENASFYNHVIIVTEESAEVTYVENYLSNASGEGNQLNIISEVIAGANSNITYGSVDYMDKGFTGHIIRRGITEADASINWALGLMNEGSQIIDNTTNLFGDRSTSSLKSVVVGTGEQKINLTSKIVQYGKETDGYILKHGVMKEHASSVFNGIGYIKHGGTKSIANQESRVLMLSEHARGDANPILLIDEDDVQAGHAASVGRVDPDQLYYLMSRGISQREAERLVIHGFLDPVVRELPIEDVKRQLREVIERKVSK
>NC_002952.2|WP_001006454.1|915843_917094_+|cysteine-desulfurase
MNEVAEHSFDVNEVIKDFPILDQKVNGKRLAYLDSTATSQTPVQVLNVLEDYYKRYNSNVHRGVHTLGSLATDGYENARETVRRFINAKYFEEIIFTRGTTASINLVAHSYGDANVEEGDEIVVTEMEHHANIVPWQQLAKRKNATLKFIPMTADGELNIEDIKQTINDKTKIVAIAHISNVLGTINDVKTIAEIAHQHGAIISVDGAQAAPHMKLDMQEMNADFYSFSGHKMLGPTGIGVLFGKRELLQKMEPIEFGGDMIDFVSKYDATWADLPTKFEAGTPLIAQAIGLAEAIRYLERIGFDAIHKYEQELTIYAYEQMSAIEGIEIYGPPKDRRAGVITFNLQDVHPHDVATAVDTEGVAVRAGHHCAQPLMKWLNVSSTARASFYIYNTKEDVDQLINALKQTKEFFSYEF

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_002952_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002952_3

956456-956541

Orphan

Consensus_repeat	Method
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_002952_3

>merge|NC_002952|3|956456-956541|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGGCGGGGCCCCAACACAGAAGCTGGTGGAAAGCCAGCTTACAATAATGTGCAAGTTGG

>NC_002952|3|3|956456-956541|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CGGGGCCCCAACACAGAAGCTGGTGG
AAAGCCAGCTTACAATAATGTGCAAGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_002952.2\|WP_000054599.1\|947596_950002_-\|Na+/H+-antiporter-subunit-A	unknown	unknown	gnl\|CDD\|237155
NC_002952.2\|WP_000007960.1\|962452_963028_+\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NC_002952.2\|WP_000758217.1\|963032_963557_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_002952.2\|WP_000035058.1\|950579_951173_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|238908
NC_002952.2\|WP_000660054.1\|959239_960445_-\|argininosuccinate-synthase	unknown	unknown	gnl\|CDD\|234785
NC_002952.2\|WP_000172367.1\|964307_967784_+\|helicase-exonuclease-AddAB-subunit-AddB	unknown	unknown	gnl\|CDD\|213736
NC_002952.2\|WP_000154950.1\|967784_971438_+\|helicase-exonuclease-AddAB-subunit-AddA	unknown	unknown	gnl\|CDD\|274299
NC_002952.2\|WP_001081626.1\|947175_947604_-\|Na(+)/H(+)-antiporter-subunit-B	unknown	unknown	gnl\|CDD\|183602
NC_002952.2\|WP_000167321.1\|953761_954952_+\|ornithine--oxo-acid-transaminase	unknown	unknown	gnl\|CDD\|179736
NC_002952.2\|WP_000148855.1\|960795_962127_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|184504
NC_002952.2\|WP_000185311.1\|956699_957629_-\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176543
NC_002952.2\|WP_000402803.1\|946834_947176_-\|Na(+)/H(+)-antiporter-subunit-C	unknown	unknown	gnl\|CDD\|181497
NC_002952.2\|WP_000573088.1\|945345_946842_-\|Na+/H+-antiporter-subunit-D	unknown	unknown	gnl\|CDD\|181085
NC_002952.2\|WP_000138487.1\|955060_956305_+\|Glu/Leu/Phe/Val-dehydrogenase	unknown	unknown	gnl\|CDD\|223411
NC_002952.2\|WP_000066056.1\|957870_959250_-\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NC_002952.2\|WP_000781164.1\|950132_950516_-\|kinase-associated-lipoprotein-B	unknown	unknown	gnl\|CDD\|378054
NC_002952.2\|WP_000838047.1\|952326_953454_+\|NADH-dependent-flavin-oxidoreductase	unknown	unknown	gnl\|CDD\|240086
NC_002952.2\|WP_000711897.1\|963572_964148_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_002952.2\|WP_001067294.1\|951587_951965_+\|S1-RNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224023
NC_002952.2\|WP_000670753.1\|971603_972506_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257

Protein	Function_ID	Function_description	E-value
NC_002952.2\|WP_000054599.1\|947596_950002_-\|Na+/H+-antiporter-subunit-A	gnl\|CDD\|237155	PRK12645, PRK12645, monovalent cation/H+ antiporter subunit A; Reviewed.	0
NC_002952.2\|WP_000007960.1\|962452_963028_+\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	4.0006e-40
NC_002952.2\|WP_000758217.1\|963032_963557_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	2.75286e-49
NC_002952.2\|WP_000035058.1\|950579_951173_+\|peptidylprolyl-isomerase	gnl\|CDD\|238908	cd01927, cyclophilin_WD40, cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the protein is not known.	3.93388e-65
NC_002952.2\|WP_000660054.1\|959239_960445_-\|argininosuccinate-synthase	gnl\|CDD\|234785	PRK00509, PRK00509, argininosuccinate synthase; Provisional.	0
NC_002952.2\|WP_000172367.1\|964307_967784_+\|helicase-exonuclease-AddAB-subunit-AddB	gnl\|CDD\|213736	TIGR02773, ATP-dependent_helicase/deoxyribonuclease_subunit_B, helicase-exonuclease AddAB, AddB subunit. DNA repair is accomplished by several different systems in prokaryotes. Recombinational repair of double-stranded DNA breaks involves the RecBCD pathway in some lineages, and AddAB (also called RexAB) in other. The AddA protein is conserved between the firmicutes and the alphaproteobacteria, while the partner protein is not. Nevertheless, the partner is designated AddB in both systems. This model describes the AddB protein as found Bacillus subtilis and related species. Although the RexB protein of Streptococcus and Lactococcus is considered to be orthologous, functionally equivalent, and merely named differently, all members of this protein family have a P-loop nucleotide binding motif GxxGxGK[ST] at the N-terminus, unlike RexB proteins, and a CxxCxxxxxC motif at the C-terminus, both of which may be relevant to function. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_002952.2\|WP_000154950.1\|967784_971438_+\|helicase-exonuclease-AddAB-subunit-AddA	gnl\|CDD\|274299	TIGR02785, ATP-dependent_helicase/nuclease_subunit_A, helicase-exonuclease AddAB, AddA subunit, Firmicutes type. AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_002952.2\|WP_001081626.1\|947175_947604_-\|Na(+)/H(+)-antiporter-subunit-B	gnl\|CDD\|183602	PRK12573, PRK12573, Na(+)/H(+) antiporter subunit B.	9.17513e-61
NC_002952.2\|WP_000167321.1\|953761_954952_+\|ornithine--oxo-acid-transaminase	gnl\|CDD\|179736	PRK04073, rocD, ornithine--oxo-acid transaminase; Provisional.	0
NC_002952.2\|WP_000148855.1\|960795_962127_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|184504	PRK14097, pgi, glucose-6-phosphate isomerase; Provisional.	0
NC_002952.2\|WP_000185311.1\|956699_957629_-\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176543	cd08601, GDPD_SaGlpQ_like, Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized glycerophosphodiester phosphodiesterase (GP-GDE, EC 3.1.4.46) from Staphylococcus aureus, Bacillus subtilis and similar proteins. Members in this family show very high sequence similarity to Escherichia coli periplasmic phosphodiesterase GlpQ, which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	8.83368e-151
NC_002952.2\|WP_000402803.1\|946834_947176_-\|Na(+)/H(+)-antiporter-subunit-C	gnl\|CDD\|181497	PRK08600, PRK08600, putative monovalent cation/H+ antiporter subunit C; Reviewed.	9.82501e-64
NC_002952.2\|WP_000573088.1\|945345_946842_-\|Na+/H+-antiporter-subunit-D	gnl\|CDD\|181085	PRK07691, PRK07691, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0
NC_002952.2\|WP_000138487.1\|955060_956305_+\|Glu/Leu/Phe/Val-dehydrogenase	gnl\|CDD\|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	0
NC_002952.2\|WP_000066056.1\|957870_959250_-\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NC_002952.2\|WP_000781164.1\|950132_950516_-\|kinase-associated-lipoprotein-B	gnl\|CDD\|378054	pfam08810, KapB, Kinase associated protein B. This bacterial protein forms an anti-parallel beta sheet with an extending alpha helical region.	1.97361e-52
NC_002952.2\|WP_000838047.1\|952326_953454_+\|NADH-dependent-flavin-oxidoreductase	gnl\|CDD\|240086	cd04735, OYE_like_4_FMN, Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	0
NC_002952.2\|WP_000711897.1\|963572_964148_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.63465e-53
NC_002952.2\|WP_001067294.1\|951587_951965_+\|S1-RNA-binding-domain-containing-protein	gnl\|CDD\|224023	COG1098, VacB, Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis].	3.22125e-44
NC_002952.2\|WP_000670753.1\|971603_972506_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	6.54658e-87

>NC_002952.2|WP_000138487.1|955060_956305_+|Glu/Leu/Phe/Val-dehydrogenase
MTENNNLVTSTQGIIKEALHKLGFDEGMYDLIKEPLRMLQVRIPVRMDDGTVKTFTGYRAQHNDAVGPTKGGVRFHPDVDEEEVKALSMWMTLKCGIVNLPYGGGKGGIVCDPRQMSIHEVERLSRGYVRAISQFVGPNKDIPAPDVFTNSQIMAWMMDEYSALDKFNSPGFITGKPIVLGGSHGRDRSTALGVVIAIEQAAKRRNMQIEGAKVVIQGFGNAGSFLAKFLYDLGAKIVGISDAYGALHDPNGLDIDYLLDRRDSFGTVTNLFEETISNKELFELDCDILVPAAISNQITEDNAHDIKASIVVEAANGPTTPEATRILTERGILLVPDVLASAGGVTVSYFEWVQNNQGYYWSEEEVNEKLREKLEAAFDTIYELSQNRKIDMRLAAYIIGIKRTAEAARYRGWA
>NC_002952.2|WP_000167321.1|953761_954952_+|ornithine--oxo-acid-transaminase
MTKSEKIIELTNHYGAHNYLPLPIVISEAEGVWVKDPEGNKYMDMLSAYSAVNQGHRHPKIIQALKDQADKVTLVSRAFHSDNLGEWYEKICKLAGKDKALPMNTGAEAVETALKAARRWAYDVKGIEPNKAEIIAFNGNFHGRTMAPVSLSSEAEYQRGYGPLLDGFRKVDFGDVDALKAAINKNTAAVLVEPIQGEAGINIPPEGYLKAIRELCDEHNVLFIADEIQAGLGRSGKLFARDWDNVKPDVYILGKALGGGVFPISVVLADKEVLDVFTPGSHGSTFGGNPLACAASIAALDVIVDEDLPGRSLELGDYFKEQLKQIDHPSIKEVRGRGLFIGVELNESARPYCEALKEEGLLCKETHDTVIRFAPPLIITKEELDLALEKIRHVFQ
>NC_002952.2|WP_000838047.1|952326_953454_+|NADH-dependent-flavin-oxidoreductase
MKSKYEPLFDKVVLPNGVELRNRFVLAPLTHISSNDDGTISDIELPYIEKRSQDVGITSNAASNVSDVGKAFPGQPSIAHDSDIEGLKRLATAMKKNGAKALVQIHHGGAQALPELTPDGDVVAPSPISLKSFGQKQEHSAREMTNEEIEQAIKDFGEATRRAIEAGFDGVEIHGANHYLIHQFVSPYYNRRNDVWANQYKFPIAVIEEVLKSKEVYGNKDFIVGYRLSPEEAESPGITMEITEELVNKISHMPIDYIHVSMMDTHATAREGKYAGQERLPLIHKWINGRMPLIGIGSIFTADDALDAVENVGVDLVAIGRELLLDYQFVEKIKDGREDEIINYFDPEREDNHHLTPNLWHQFNEGFYPLPRKDK
>NC_002952.2|WP_001067294.1|951587_951965_+|S1-RNA-binding-domain-containing-protein
MNNYKIGQHIKVRVTGIQPYGAFVETPNHTEGLIHISEIMDDYVHNLKKFLSEGQIVKAKILSIDDEGKLNLSLKDNDYFKNYERKKEKQSVLDEIRETEKYGFQTLKERLPIWIKQSKRAIRND
>NC_002952.2|WP_000035058.1|950579_951173_+|peptidylprolyl-isomerase
MANYPQLNKEVQQGEIKVVMHTNKGDMTFKLFPNIAPKTVENFVTHAKNGYYDGITFHRVINDFMIQGGDPTATGMGGESIYGGAFEDEFSLNAFNLYGALSMANSGPNTNGSQFFIVQMKEVPQNMLSQLADGGWPQPIVDAYGEKGGTPWLDQKHTVFGQIIDGETTLEDIANTKVGPQDKPLHDVVIESIDVEE
>NC_002952.2|WP_000781164.1|950132_950516_-|kinase-associated-lipoprotein-B
MKLYRFSHKTGSYGVTIVEENGDDVLVKVEQVIKHPKQGDLHNPTETEGVFFHERKALSHFEKRYTKRSQLRDFNVDVLRYEDSLQQAITDLETKLKTQQTKHAEMSLASLARLKEDYSLQYKENFK
>NC_002952.2|WP_000054599.1|947596_950002_-|Na+/H+-antiporter-subunit-A
MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARMTPIFAASQGWIWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASKANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAILATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTVFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVIIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE
>NC_002952.2|WP_001081626.1|947175_947604_-|Na(+)/H(+)-antiporter-subunit-B
MNRQQNDLILQFAAVIIFFMVMVFGFSLFLAGHYTPGGGFVGGLLFASSLVIITIAFDIETMRKIFPLDFKILIGIGLVFCIATPIASWFLGKNFFTHVTFDIPLFILEPVHMTTAVFFDFGVLCAVVGTVMTIIISIGENE
>NC_002952.2|WP_000402803.1|946834_947176_-|Na(+)/H(+)-antiporter-subunit-C
MEIIMIFVSGILTAISVYLVLSKSLIRIVMGTTLLTHAANLFLITMGGLKHGTVPIYEANVKSYVDPIPQALILTAIVIAFATTAFFLVLAFRTYKELGTDNVESMKGVPEDD
>NC_002952.2|WP_000573088.1|945345_946842_-|Na+/H+-antiporter-subunit-D
MIESNMLVLTLVIPVITAILLVFIGKRPIIKRYVALGGTLLTLVAAIINLANVVKHGPLRVELGSWKAPYSIVFVLDIFSALLIITSIIITAIVILYSYQTIGIERERYYYYFSVLFMLIGIIGAFTTGDIFNLFVFFEVFLMSSYFLLVIGSTKIQLQETIKYVLVNVVSSSFFVMGVAILYSVVGTLNLADISNKLANLSAHDSGLVNIVFILFIFVFATKAGVFPMFVWLPSAYYAPPIPIIAFFGALLTKVGVYAITRTLSLFFSDNVSFSHYVILFLALLTIIFGCVGAVAYANIKKIILYNVMIAVGVILVGVAMMTESGMIGAIYYTLHDMLVKLALFLLIGIMIKITGTADLRQFGGLIKRYPVLGWSFFIAALSLAGIPPLSGFYGKFFIVQSTFERGFYLSGVIVLLSSLVVLYSVIRIFLQGFFGQPKGYDLNNKVDVKYLTTIAIVAVVITVLYGLSADYLYPMVKAGAETFYNPSTYVKAVLGGK
>NC_002952.2|WP_000185311.1|956699_957629_-|glycerophosphodiester-phosphodiesterase
MTNSSKSFTKFMAASAVFTMGFLSVPTAGAEQTNHIANKPQAIQWHTNLTNERFTTIAHRGASGYAPEHTFQAYDKSHNELKASYIEIDLQRTKDGHLVAMHDENVNRTTNGHGKVEDYTLDELKQLDAGSWFNKKYPKYARASYKNAKVPTLDEILERYGPNANYYIETKSPDVYPGMEEQLLASLKKHHLLNKNKLKNGHVMIQSFSDESLKKIHRQNKHVPLVKLVDKGELQQFNDQRLKEIRSYAIGLGPDYTDLTEQNTHHLKDLGFIVHPYTVNEKADMLRLNKYGVDGVFTNFADKYKEVIK
>NC_002952.2|WP_000066056.1|957870_959250_-|argininosuccinate-lyase
MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSASLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPGYTHLQRAQPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETLHNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNKDMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGHYLLDVPLSTYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ
>NC_002952.2|WP_000660054.1|959239_960445_-|argininosuccinate-synthase
MKEKIVLAYSGGLDTSVAVQWLIDKGYDVVACCLDVGEGKDLDIVYKKALDMRAVECHIIDATKEFSDEYVSYAIKGNLMYENAYPLVSALSRPLIAKKLVEIAEKTNSVGIAHGCTGKGNDQVRFEVAIKALNPSLKAFAPVREWAWSREEEIDYAIKHNIPVSINHDSPYSIDQNLWGRANECGILEDPYAAPPEDAFDLTNALEETPDTADEIILTFDKGIPVQIDGKTYELDDLILTLNALAGKHGIGRIDHVENRLVGIKSREIYEAPAAEVILKAHKALETITLTKDVAHFKPIIEKQFAEQLYNGLWFSPLTDSLKLFIDSTQQYVSGDVRIKLFKGNAIVNGRKSPYTLYDEKLATYTKEDAFNQDAAVGFIDIYGLPTQVNAMLHGGYSNEQ
>NC_002952.2|WP_000148855.1|960795_962127_+|glucose-6-phosphate-isomerase
MTHIQLDFSKTLEFFGEHELKQQQEIVKSIHKTIHEGTGAGSDFLGWVDLPVDYDKEEFSRIVEASKRIKENSDVLVVIGIGGSYLGARAAIEMLTSSFRNSNEYPEIVFVGNHLSSTYTKELVDYLADKDFSVNVISKSGTTTEPAVAFRLFKQLVEERYGKEEAQKRIFATTDKEKGALKQLATNEGYETFIVPDDVGGRYSVLTAVGLLPIATAGINIEAMMIGAAKAREELSSDKLEENIAYQYATIRNILYAKGYTTEMLINYEPSMQYFNEWWKQLFGESEGKDFKGIYPSSANYTTDLHSLGQYVQEGRRFLFETVVKVNHPKYDITIEKDSDDLDGLNYLAGKTIDEVNTKAFEGTLLAHTDGGVPNMVVNIPQLDEETFGYVVYFFELACAMSGYQLGVNPFNQPGVEAYKQNMFALLGKPGFEDLKKELEERL
>NC_002952.2|WP_000007960.1|962452_963028_+|TVP38/TMEM64-family-protein
MSFHQVEEWFEIFRQFGYLPGFILLYIRAIIPVFPLALYILINIQAYGPILGILISWLGLISGTFTVYLICKRLVDTERMQRIKQRTAVQRLISFIDRQGLIPLFILLCFPFTPNTLINFVASLSHIRPKYYFIVLASSKLVSTIILGYLGKEITTILTHPLRGILMLVVLIVFWIVGKKLEQHFMGSKKE
>NC_002952.2|WP_000758217.1|963032_963557_+|signal-peptidase-I
MKKVVKYLISLILAIIIVLFVQTFVIVGHVIPNNDMSPTLNKGDRVIVNKIKVTFNQLNNGDIITYRRGNEIYTSRIIAKPGQSMAFRQGQLYRDDRPVDASYAKNRKIKDFSLRNFKKLDGDIIPPNNFVVLNDHDNNQHDSRQFGLIDKKDIIGNISLRYYPFSKWTIQFKS
>NC_002952.2|WP_000711897.1|963572_964148_+|signal-peptidase-I
MKKELLEWIISIAVAFVILFIVGKFIVTPYTIKGESMDPTLKDGERVAVNIIGYKTGGLEKGNVVVFHANKNDDYVKRVIGVPGDKVEYKNDTLYVNGKKQDEPYLNYNLKHKQGDYITGTFQVKDLPNANPKSNVIPKGKYLVLGDNREVSKDSRAFGLIDEDQIVGKVSFRFWPFSEFKYNFNPENTKN
>NC_002952.2|WP_000172367.1|964307_967784_+|helicase-exonuclease-AddAB-subunit-AddB
MTLHAYLGRAGTGKSTKMLTEIKQKMKADPLGDPIILIAPTQSTFQLEQAFVNDPELNGSLRTEVLHFERLSHRIFQEVGSYSEQKLSKAATEMMIYNIVQEQQKYLKLYQSQAKYYGFSEKLTEQIQDFKKYAVTPEHLESFIADKNMQTRTKNKLEDIALIYREFEQRIQNEFITGEDALQYFIDCMPKSEWLKRADIYIDGFHNFSTIEYLIIKGLIKYAKSVTIILTTDGNHDQFSLFRKPSEVLRHIEEISNELNISIERQYFNQLYRFNNQDLKHLEQEFDALQINRVACQGHINILESATMREEINEIARRIIVDIRDKQLRYQDIAILYRDESYAYLFDSILPLYNIPYNIDTKRSMTHHPVMEMIRSLIEVIQSNWQINPMLRLLKTDVLTTSYLKSAYLVDLLENFVLERGIYGKRWLDDELFNVEHFSKMGRKAHKLTEDERNTFEQVVKLKKDVIDKILHFEKQMSQAATVKDFATAFYESMEYFELPNQLMTERDELDLNGNHEKAEEIDQIWNGLIQILDDLVLVFGDEPMSMERFLEVFDIGLEQLEFVMIPQTLDQVSIGTMDLAKVDNKQHVYLVGMNDGTMPQPVTASSLITDEEKKYFEQQANVELSPTSDILQMDEAFVCYVAMTRAKGNVTFSYSLMGSSGDDKEISPFLNQIQSLFNQLEITNIPQYHEVNPLSLMQHAKQTKITLFEALRAWLDDEIVADSWLDAYQVIRDSDHLSQGLDYLMSALTFDNETVKLGETLSKDLYGKEINASVSRFEGYQQCPFKHYASHGLKLNERTKYELQNFDLGDIFHSVLKYISERINGDFKQLDLKKIRQLTNEALEEILPKVQFNLLNSSAYYRYLSRRIGAIVETTLSALKYQGTYSKFMPKHFETSFRRKPRTNDELIAQTLTTTQGIPINIRGQIDRIDTYTKNDTSFVNIIDYKSSEGSATLDLTKVYYGMQMQMMTYMDIVLQNKQRLGLTDIVKPGGLLYFHVHEPRIKFKSWADIDEDKLEQDLIKKFKLSGLVNADQTVIDALDIRLEPKFTSDIVPVGLNKDGSLSKRGSQVADEATIYKFIQHNKENFIETASNIMDGHTEVAPLKYKQKLPCAFCSYQSVCHVDGMIDSKRYRTVDETINPIEAIQNININDEFGGEQ
>NC_002952.2|WP_000154950.1|967784_971438_+|helicase-exonuclease-AddAB-subunit-AddA
MTIPEKPQGVIWTDAQWQSIYETGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADPANAHLKNQRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENILLLEQTIDEVIEQHYDILDPAFIELTEQLSSDRSDDQFRMIIKQLYFFSVANPNPTNWLDQLVTPYEEEAQQAQLIQLLTDLSKVFITAAYDALNKAYDLFSMMDGVDKHLAVIEDERRLMGRVLEGGFIDISYLTGHEFGARLPNVTAKIKEANEMMVDALEDAKLQYKKYKSLIDKVKSDYFSREADDLKADMQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDGSPSEIAESYRQHFHEILVDEYQDTNRVQEKILSCIKTGDEHNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFTLDGDGTGRRIDLSQNFRSRKEVLSTTNYIFKHMMDEQVGEVRYDEAAQLYYGAPYDESDHPVNLKVLVEADQEHSDLTGSEQEAHFIVEQVKDILEHQKVFDMKTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRSVIYQFKEDELAQIRILSPNDDYFYQSIVNYINDEAADAILVDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVIQYFSGLIGGRGRRANLYGLFNKAIEFENSSFRGLYQFIRFIDELIERGKDFGEENVVGPNDNVVRMMTIHSSKGLEFPFVIYSGLSKDFNKRDLKQPVILNQQFGLGMDYFDVDKEMAFPSLASVAYKAVAEKKLVSEEMRLVYVALTRAKEQLYLIGRVKNDKSLLELEQLSISGEHIAVNERLTSPNPFHLIYSILSKHQSASIPDDLKFEKDIAQIEDSSRPNVNISIIYFEDVSTETILDNDEYRSVNQLETMQNGNEDVKAQIKHQLDYQYPYVNDTKKPSKQSVSELKRQYETEESGTSYERVRQYRIGFSTYERPKFLSEQGKRKANEIGTLMHTVMQHLPFKKERISEVELHQYIDGLIDKHIIEADTKKDIRMDEIMTFINSELYSIIAEAEQVYRELPFVVNQALVDQLPQGDEDVSIIQGMIDLIFVKDGVHYFVDYKTDAFNRRRGMTDEEIGTQLKNKYKIQMKYYQNTLQTILNKEVKGYLYFFKFGTLQL
>NC_002952.2|WP_000670753.1|971603_972506_+|fumarylacetoacetate-hydrolase-family-protein
MKFLSFKYNDKTSYGVKVKREDAVWDLTQVFADFAEGDFHPKTLLAGLQQNHTLDFQEQVRKAVVAAEDSGKAEDYKISFNDIEFLPPVTPPNNVIAFGRNYKDHANELNHEVERLYVFTKAASSLTGDNAKIPNHKDITDQLDYEGELGIVIGKSGEKIPKALALDYVYGYTIINDITDRKAQSEQDQAFLSKSLTGGCPMGPYIVTKDELPLPENVNIVTKVNNEIRQDGNTGEMILKIDELIEEISKYVALHPGDIIATGTPAGVGAGMQPPKFLQPGDEVKVTIDNIGTLTTYIAK

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Crispr_ID: NC_002952_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002952_4

1257575-1257667

Unclear

Consensus_repeat	Method
TAAGAAACAGTAATCAATAAATTGATAACT	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NC_002952_4

>merge|NC_002952|4|1257575-1257667|CRISPRCasFinder
TAAGAAACAGTAATCAATAAATTGATAACTAATAAGCGGAACGCCTGAGCTAAAGCTCATGCATAAGAAACAGTAATCAATAAATTGATAACT

>NC_002952|4|4|1257575-1257667|CRISPRCasFinder
TAAGAAACAGTAATCAATAAATTGATAACT	AATAAGCGGAACGCCTGAGCTAAAGCTCATGCA
TAAGAAACAGTAATCAATAAATTGATAACT

Protein	Signature genes	Signature genes Name	Protein_function
NC_002952.2\|WP_001548538.1\|1254241_1254814_+\|transcription-factor-FapR	unknown	unknown	gnl\|CDD\|179847
NC_002952.2\|WP_001151515.1\|1251978_1254039_+\|ATP-dependent-DNA-helicase-RecG	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236794
NC_002952.2\|WP_000167269.1\|1256716_1257451_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl\|CDD\|235500
NC_002952.2\|WP_000171418.1\|1249753_1250128_+\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|224221
NC_002952.2\|WP_000863474.1\|1264144_1265512_+\|signal-recognition-particle-protein	unknown	unknown	gnl\|CDD\|236780
NC_002952.2\|WP_000687323.1\|1266912_1267650_+\|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	unknown	unknown	gnl\|CDD\|234581
NC_002952.2\|WP_000239746.1\|1254818_1255805_+\|phosphate-acyltransferase-PlsX	unknown	unknown	gnl\|CDD\|235414
NC_002952.2\|WP_000547905.1\|1248100_1248742_+\|thiamine-diphosphokinase	unknown	unknown	gnl\|CDD\|224480
NC_002952.2\|WP_000181404.1\|1267752_1268103_+\|50S-ribosomal-protein-L19	unknown	unknown	gnl\|CDD\|235418
NC_002952.2\|WP_000268754.1\|1265946_1266222_+\|30S-ribosomal-protein-S16	unknown	unknown	gnl\|CDD\|223306
NC_002952.2\|WP_000262717.1\|1258983_1262550_+\|chromosome-segregation-protein-SMC	unknown	unknown	gnl\|CDD\|224117
NC_002952.2\|WP_000623906.1\|1250142_1251789_+\|DAK2-domain-containing-protein	unknown	unknown	gnl\|CDD\|224378
NC_002952.2\|WP_001261982.1\|1266409_1266913_+\|ribosome-maturation-factor-RimM	unknown	unknown	gnl\|CDD\|234650
NC_002952.2\|WP_000164332.1\|1247449_1248094_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NC_002952.2\|WP_000517908.1\|1249122_1249311_-\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NC_002952.2\|WP_000047355.1\|1255797_1256724_+\|ACP-S-malonyltransferase	unknown	unknown	gnl\|CDD\|223408
NC_002952.2\|WP_000531319.1\|1263786_1264119_+\|putative-DNA-binding-protein	unknown	unknown	gnl\|CDD\|234647
NC_002952.2\|WP_000043237.1\|1258105_1258837_+\|ribonuclease-III	unknown	unknown	gnl\|CDD\|234633
NC_002952.2\|WP_000426914.1\|1257756_1257990_+\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|179197
NC_002952.2\|WP_000007675.1\|1262549_1263800_+\|signal-recognition-particle-docking-protein-FtsY	unknown	unknown	gnl\|CDD\|236686

Protein	Function_ID	Function_description	E-value
NC_002952.2\|WP_001548538.1\|1254241_1254814_+\|transcription-factor-FapR	gnl\|CDD\|179847	PRK04424, PRK04424, transcription factor FapR.	2.37773e-98
NC_002952.2\|WP_001151515.1\|1251978_1254039_+\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NC_002952.2\|WP_000167269.1\|1256716_1257451_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	3.68137e-140
NC_002952.2\|WP_000171418.1\|1249753_1250128_+\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|224221	COG1302, COG1302, Uncharacterized protein conserved in bacteria [Function unknown].	4.1554e-37
NC_002952.2\|WP_000863474.1\|1264144_1265512_+\|signal-recognition-particle-protein	gnl\|CDD\|236780	PRK10867, PRK10867, signal recognition particle protein; Provisional.	0
NC_002952.2\|WP_000687323.1\|1266912_1267650_+\|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	gnl\|CDD\|234581	PRK00026, trmD, tRNA (guanine-N(1)-)-methyltransferase; Reviewed.	3.27017e-164
NC_002952.2\|WP_000239746.1\|1254818_1255805_+\|phosphate-acyltransferase-PlsX	gnl\|CDD\|235414	PRK05331, PRK05331, phosphate acyltransferase PlsX.	7.80762e-178
NC_002952.2\|WP_000547905.1\|1248100_1248742_+\|thiamine-diphosphokinase	gnl\|CDD\|224480	COG1564, THI80, Thiamine pyrophosphokinase [Coenzyme metabolism].	1.16343e-81
NC_002952.2\|WP_000181404.1\|1267752_1268103_+\|50S-ribosomal-protein-L19	gnl\|CDD\|235418	PRK05338, rplS, 50S ribosomal protein L19; Provisional.	6.77895e-70
NC_002952.2\|WP_000268754.1\|1265946_1266222_+\|30S-ribosomal-protein-S16	gnl\|CDD\|223306	COG0228, RpsP, Ribosomal protein S16 [Translation, ribosomal structure and biogenesis].	3.01687e-41
NC_002952.2\|WP_000262717.1\|1258983_1262550_+\|chromosome-segregation-protein-SMC	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	0
NC_002952.2\|WP_000623906.1\|1250142_1251789_+\|DAK2-domain-containing-protein	gnl\|CDD\|224378	COG1461, COG1461, Predicted kinase related to dihydroxyacetone kinase [General function prediction only].	0
NC_002952.2\|WP_001261982.1\|1266409_1266913_+\|ribosome-maturation-factor-RimM	gnl\|CDD\|234650	PRK00122, rimM, 16S rRNA-processing protein RimM; Provisional.	1.86157e-68
NC_002952.2\|WP_000164332.1\|1247449_1248094_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	1.52718e-114
NC_002952.2\|WP_000517908.1\|1249122_1249311_-\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	1.3072e-18
NC_002952.2\|WP_000047355.1\|1255797_1256724_+\|ACP-S-malonyltransferase	gnl\|CDD\|223408	COG0331, FabD, (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism].	6.35101e-134
NC_002952.2\|WP_000531319.1\|1263786_1264119_+\|putative-DNA-binding-protein	gnl\|CDD\|234647	PRK00118, PRK00118, putative DNA-binding protein; Validated.	1.00966e-46
NC_002952.2\|WP_000043237.1\|1258105_1258837_+\|ribonuclease-III	gnl\|CDD\|234633	PRK00102, rnc, ribonuclease III; Reviewed.	4.78039e-115
NC_002952.2\|WP_000426914.1\|1257756_1257990_+\|acyl-carrier-protein	gnl\|CDD\|179197	PRK00982, acpP, acyl carrier protein; Provisional.	5.23888e-31
NC_002952.2\|WP_000007675.1\|1262549_1263800_+\|signal-recognition-particle-docking-protein-FtsY	gnl\|CDD\|236686	PRK10416, PRK10416, signal recognition particle-docking protein FtsY; Provisional.	0

>NC_002952.2|WP_000167269.1|1256716_1257451_+|3-oxoacyl-[acyl-carrier-protein]-reductase
MTKSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQANVADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNCIQKATPQMLRQRSGAIINLSSVVGAVGNPGQANYVATKAGVIGLTKSAARELASRGITVNAVAPGFIVSDMTDALSDELKEQMLTQIPLARFGQDTDIANTVAFLASDKAKYITGQTIHVNGGMYM
>NC_002952.2|WP_000047355.1|1255797_1256724_+|ACP-S-malonyltransferase
MSKTAIIFPGQGAQKVGMAQDLYNNNDQATEILTSAANTLDFDILETMFTDEEGKLGETENTQPALLTHSSALLAALKNLNPDFTMGHSLGEYSSLVAADVLSFEDAVKIVRKRGQLMAQAFPSGVGSMAAVLGLDFDKVDEICKSLSSDDKIIEPANINCPGQIVVSGHKALIDELVEKGKSLGAKRVMPLAVSGPFHSSLMKVIEEDFSSYINQFEWRDAKFPVVQNVNAQGETDKEVIKSNMVKQLYSPVQFINSTEWLIDQGVDHFIEIGPGKVLSGLIKKINRDVKLTSIQTLEDVKGWNEND
>NC_002952.2|WP_000239746.1|1254818_1255805_+|phosphate-acyltransferase-PlsX
MVKLAIDMMGGDNAPDIVLEAVQKAVEDFKDLEIILFGDEKKYNLNHERIEFRHCSEKIEMEDEPVRAIKRKKDSSMVKMAEAVKSGEADGCVSAGNTGALMSAGLFIVGRIKGVARPALVVTLPTIDGKGFVFLDVGANADAKPEHLLQYAQLGDIYAQKIRGIDNPKISLLNIGTEPAKGNSLTKKSYELLNQDHSLNFVGNIEAKTLMDGDTDVVVTDGYTGNMVLKNLEGTAKSIGKMLKDTIMSSTKNKIAGAILKKDLAEFAKKMDYSEYGGSVLLGLEGTVVKAHGSSNAKAFYSAIRQAKIAGEQNIVQTMKETVGESNE
>NC_002952.2|WP_001548538.1|1254241_1254814_+|transcription-factor-FapR
MRGETLKLKKDKRREAIRQQIDSNPFITDHELSDLFQVSIQTIRLDRTYLNIPELRKRIKLVAEKNYDQISSIEEQEFIGDLIQVNPNVKAQSILDITSDSVFHKTGIARGHVLFAQANSLCVALIKQPTVLTHESSIQFIEKVKLNDTVRAEARVVNQTAKHYYVEVKSYVKHTLVFKGNFKMFYDKRG
>NC_002952.2|WP_001151515.1|1251978_1254039_+|ATP-dependent-DNA-helicase-RecG
MAKVNLIESPYSLLQLKGIGPKKIEVLQQLNIHTVEDLVLYLPTRYEDNTVIDLNQAEDQSNVTIEGQVYTAPVVAFFGRNKSKLTVHLMVNNIAVKCIFFNQPYLKKKIELNQTITVKGKWNRVKQEITGNRVFLNSQGTQTQENADVQLEPVYRIKEGIKQKQIRDQIRQALNDVTIHEWLTDELREKYKLETLDFTLNTLHHPKSKEDLLRARRTYAFTELFLFELRMQWLNRLEKSSDEAIEIDYDLDQVKSFIDRLPFELTEAQKSSVNEIFRDLKAPIRMHRLLQGDVGSGKTVVAAICMYALKTAGYQSALMVPTEILAEQHAESLIALFGDSMNVALLTGSVKGKKRKILLEQLENRTIDCLIGTHALIQDDVIFHNVGLVITDEQHRFGVNQRQLLREKGAMTNVLFMTATPIPRTLAISVFGEMDVSSIKQLPKGRKPIITTWAKHEQYDKVLMQMTSELKKGRQAYVICPLIESSEHLEDVQNVVALYESLQQYYGVSRVGLLHGKLSADEKDEVMQKFSNHEIDVLVSTTVVEVGVNVPNATFMMIYDADRFGLSTLHQLRGRVGRSDQQSYCVLIASPKTETGIERMTIMTQTTDGFELSERDLEMRGPGDFFGVKQSGLPDFLVANLVEDYRMLEVARDEAAELIQSGVFFENTYQHLRHFVEENLLHRSFD
>NC_002952.2|WP_000623906.1|1250142_1251789_+|DAK2-domain-containing-protein
MISKINGKLFADMIIQGAQNLSNNADLVDSLNVYPVPDGDTGTNMNLTMTSGREEVENNLSKNIGELGKTFSKGLLMGARGNSGVILSQLFRGFCKNIESESEINSKLLAESFQAGVETAYKAVMKPVEGTILTVAKDAAQAAIEKANNTEDCIELMEYIIVKANESLENTPNLLAVLKEVGVVDSGGKGLLCVYEGFLKALKGEKVEAKVAKLDKDEFVHDEHDFHGVINTEDIIYGYCTEMMVRFGKNKKAFDEQEFRQDMSQFGDSLLVINDEEIVKVHVHTEYPGKVFNYGQQYGELIKLKVENMREQHREVIRKEQHTAKPKMETVETAIITISMGEGISEIFKSMGATHIISGGQTMNPSTEDIVKVIEQSKCKRAIILPNNKNILMASEQAASIVDAEAVVIPTKSIPQGISALFQYDVDATLEENKAQMADSVNNVKSGSLTYAVRDTKIDGVEIKKDAFMGLIEDKIVSSQSDQLTTVTELLNEMLADDSEILTVIIGQDAEQAVTDNMINWIEEQYPDVEVEVHEGGQPIYQYFFSVE
>NC_002952.2|WP_000171418.1|1249753_1250128_+|Asp23/Gls24-family-envelope-stress-response-protein
MTLEISNDYGKIDISNEVIASVVGGKAVECYGIVGMASRQQVRDGIAEILGHENYAKGIKVTENNGVVDIDMYIIVSYGVKISEVANNVQSTVKYTLEKSLNVSVNSINIYVQGVRVNNTGKKA
>NC_002952.2|WP_000517908.1|1249122_1249311_-|50S-ribosomal-protein-L28
MGKQCFVTGRKASTGNRRSHALNSTKRRWNANLQKVRILVDGKPKKVWVSARALKSGKVTRV
>NC_002952.2|WP_000547905.1|1248100_1248742_+|thiamine-diphosphokinase
MHINLLCSDRHLPQDIWAKSNEGKWGGVDRGALILLKHQIIPFFSVGDFDSVSKEERQLLTEQLQIKPVQAEKADTDLALAVDKAVALGFDSITIYGATGGRLDHFFGAIQLLLKKAYYKHDVHIEVIDQQNKIELLPKGQHTVEKDKSYPYISFIPMTDDVELSLAGFKYNLARQMLNIGSTLTISNEIESLQAKVTVHDGLILQIRSTDLN
>NC_002952.2|WP_000164332.1|1247449_1248094_+|ribulose-phosphate-3-epimerase
MTKLYPSLLSVDFLDLQHELKRLEEAGVDGVHFDVMDGQFVPNISIGLPILDAVRKGTTLPIDVHLMIENPEKYIASFAEHGADMISIHVESTPHIHRAIQMIKHLDKKAGVVINPGTPISQIEPILDIVDYVLVMTVNPGFGGQSFIDQCVEKIAGLNAIKMERQLNFDIEVDGGVNTDTAKVCVENGATMLVTGSFFFKQEDYKKVTQALKG
>NC_002952.2|WP_000426914.1|1257756_1257990_+|acyl-carrier-protein
MENFDKVKDIIVDRLGVDADKVTEDASFKDDLGADSLDIAELVMELEDEFGTEIPDEEAEKINTVGDAVKFINSLEK
>NC_002952.2|WP_000043237.1|1258105_1258837_+|ribonuclease-III
MSKQKKSEIVNRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPNLPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDAFEAFIGALYLDQGLDIVWKFAEKVIFPHVEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLKQIK
>NC_002952.2|WP_000262717.1|1258983_1262550_+|chromosome-segregation-protein-SMC
MVYLKSIDAIGFKSFADQTNVQFDKGVTAIVGPNGSGKSNITDAIKWVLGEQSAKSLRGSKMEDIIFSGAEHRKAQNYAEVQLRLDNHSKKLSVDENEVIVTRRLYRSGESEYYINNDRARLKDIADLFLDSGLGKEAYSIISQGRVDEILNAKPIDRRQIIEESAGVLKYKKRKAESLNKLDQTEDNLTRVEDILYDLEGRVEPLKEEAAIAKEYKTLSHQMKHSDIVVTVNDIDQYTNDNRQLDQRLNDLQGQQANKEADKQRLSQQIQQYKGKRHQLDNDVESLNYQLVKATEAFEKYTGQLNVLVERKKNQSETNARYEEEQENLIELLENISSEISEAQDTYKSLKSKQKELNAVIRELEEQLYVSDEAHDEKLEEIKNEYYTLMSEQSDVNNDIRFLKHTIEENEVKKSRLDSRLVEVFEQLKDIQGQIKTTKKEYQQTNKELSAVDKEIKNIEKDLTDTKKAQNEYEEKLYQAYRYTEKMKTRIDSLATQEEEYTYFFNGVKHILKAKNKELKGIHGAVAEIIDVPSKLTQAIETALGASLQHVIVDSEKDGRQAIQFLKERNLGRATFLPLNVIQSRAVATDIKSIAKEANGFISIASEAVKVAPEYQNIIGNLLGNTIIVDHLKHANELARAIKYRTRIVTLEGDIVNPGGSMTGGGARKSKSILSQKDELTTMRHQLEDYLRQTESFEQQFKELKIKSDQLSELYFEKSQKHNTLKEQVHHFEMELDRLTTQETQIKNDHEEFEFEKNDGYTSDKSRQTLSEKETHLESIKASLKRLEDEIERYTKLSKEGKESLTKTQQTLHQKQSDLAVVKERIKTQQQTIDRLNNQSQQTKHQLNDVKEKIAFFNSDEVMGEQAFQNIKDQINGQQETRTRLSDELDKLKQQRIELNEQIDAQEATLQVCHQDILAIENHYQDIKAEQSKLDVLIHHAIDHLNDEYQLTVERAKSEYTSDESIDALRKKVKLMKMSIDELGPVNLNAIEQFEELNERYTFLSEQRTDLRKAKETLEQIISEMDQEVTERFKETFHAIQGHFTAMFKQLFGGGDAELQLTEADYLTAGIDIVVQPPGKKLQHLSLLSGGERALTAIALLFAILKVRSAPFVILDEVEAALDEANVIRYAKYLNELSDETQFIVITHRKGTMEFADRLYGVTMQESGVTKLVSVNLNTIDDVLKEEQ
>NC_002952.2|WP_000007675.1|1262549_1263800_+|signal-recognition-particle-docking-protein-FtsY
MSFFKRLKDKFATNKENDEVKSLTEEQGQDKLEDTHSEGSTQDVNDLAENAEVKKKPRKLSEADFDDDGLISIEDFEEIEAQKMGAKFKAGLEKSRQNFQEQLNNLISRYRKVDEDFFEALEEMLITADVGFNTVMTLTEELRMEAQRRNIQDTEDLREVIVEKIVEIYHQEDDNSEAMNLEDGRLNVILMVGVNGVGKTTTIGKLAYRYKMEGKKVMLAAGDTFRAGAIDQLKVWGERVGVDVISQSEGSDPAAVMYDAINAAKNKGVDILICDTAGRLQNKTNLMQELEKVKRVINRAVPDAPHEALLCLDATTGQNALSQARNFKEVTNVTGIVLTKLDGTAKGGIVLAIRNELHIPVKYVGLGEQLDDLQPFNPESYVYGLFADMIEQNEEITTVENDQIVTEEKDDNHGAK
>NC_002952.2|WP_000531319.1|1263786_1264119_+|putative-DNA-binding-protein
MGQNDLVKTLRMNYLFDFYQSLLTNKQRNYLELFYLEDYSLSEIADTFNVSRQAVYDNIRRTGDLVEDYEKKLELYQKFEQRREIYDEMKKHLSNPEQIQRYIQQLEDLE
>NC_002952.2|WP_000863474.1|1264144_1265512_+|signal-recognition-particle-protein
MAFEGLSERLQATMQKMRGKGKLTEADIKIMMREVRLALLEADVNFKVVKEFIKTVSERALGSDVMQSLTPGQQVIKIVQDELTKLMGGENTSINMSNKPPTVVMMVGLQGAGKTTTAGKLALLMRKKYNKKPMLVAADIYRPAAINQLQTVGKQIDIPVYSEGDQVKPQQIVTNALKHAKEEHLDFVIIDTAGRLHIDEALMNELKEVKDIAKPNEIMLVVDSMTGQDAVNVAESFDDQLDVTGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLELFHPERMASRILGMGDVLSLIEKAQQDVDQEKAKDLEKKMRESSFTLDDFLEQLDQVKNLGPLDDIMKMIPGMNKMKGLDKLNMSEKQIDHIKAIIQSMTPAERNNPDTLNVSRKKRIAKGSGRSLQEVNRLMKQFNDMKKMMKQFTGGGKGKKGKRNQMQNMLKGMNLPF
>NC_002952.2|WP_000268754.1|1265946_1266222_+|30S-ribosomal-protein-S16
MAVKIRLTRLGSKRNPFYRIVVADARSPRDGRIIEQIGTYNPTSANAPEIKVDEALALKWLNDGAKPTDTVHNILSKEGIMKKFDEQKKAK
>NC_002952.2|WP_001261982.1|1266409_1266913_+|ribosome-maturation-factor-RimM
MRVEVGQIVNTHGIKGEIKVKSNSDFTDVRFQPGQVLTVVHNNNDLEYTVKSHRVHKGLHMLTFEGINNINDIEHLKGSSIYQERDHEDIVLEENEFYYSDIIGCTVFDDQETPIGRVINIFETGANDVWVIKESKEYLIPYIADVVKEVDVENKKIIITPMEGLLD
>NC_002952.2|WP_000687323.1|1266912_1267650_+|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD
MKIDYLTLFPEMFDGVLNHSIMKRAQENNKLQINTVNFRDYAINKHNQVDDYPYGGGQGMVLKPEPVFNAMEDLDVTEQARVILMCPQGEPFSHQKAVELSKADHIVFICGHYEGYDERIRTHLVTDEISMGDYVLTGGELPAMTMTDAIVRLIPGVLGNEQSHQDDSFSDGLLEFPQYTRPREFKGLTVPDVLLSGNHANIDAWRHEQKLIRTYNKRPDLIEKYPLTNADKQILERYKIGLKKG
>NC_002952.2|WP_000181404.1|1267752_1268103_+|50S-ribosomal-protein-L19
MTNHKLIEAVTKSQLRTDLPSFRPGDTLRVHVRIIEGTRERIQVFEGVVIKRRGGGVSETFTVRKISSGVGVERTFPLHTPKIEKIEVKRRGKVRRAKLYYLRSLRGKAARIQEIR

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Crispr_ID: NC_002952_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002952_5

2078901-2079092

Orphan

Consensus_repeat	Method
NNTCTNTGTTGGGGCCCNCACC	CRT

3 spacers

DEDDh

The CRISPR arrays of NC_002952_5

>merge|NC_002952|5|2078901-2079092|CRT
CTCTATGTTTGGGGCCCCACCCCAACTTGCACATTATTGTAAGCTGACAGAAAGTCAGCTTCTATGTTGGGGCCCCGCCAACTTGCATTGTCTGTAGAATTTCCTTTCGAAATTCTCTTTGTTGGGGCCCCACCCTAACTTGCACATTATTGTAAGCTGACAGAAAGTCAGCTTCTTTGTTGGGGCCCCACT

>NC_002952|5|1|2078901-2079092|CRT
CTCTATGTTTGGGGCCCCACC	CCAACTTGCACATTATTGTAAGCTGACAGAAAGTCAG
CTTCTATGTTGGGGCCCCGCC	AACTTGCATTGTCTGTAGAATTTCCTTTCGAAAT
TCTCTTTGTTGGGGCCCCACC	CTAACTTGCACATTATTGTAAGCTGACAGAAAGTCAG
CTTCTTTGTTGGGGCCCCACT

Protein	Signature genes	Signature genes Name	Protein_function
NC_002952.2\|WP_000774552.1\|2085988_2087992_-\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NC_002952.2\|WP_001147874.1\|2076369_2077731_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|225174
NC_002952.2\|WP_000613738.1\|2073731_2074286_+\|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99834
NC_002952.2\|WP_000140179.1\|2074352_2075423_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035
NC_002952.2\|WP_001250339.1\|2071235_2072549_-\|lipid-II-isoglutaminyl-synthase-subunit-MurT	unknown	unknown	gnl\|CDD\|223840
NC_002952.2\|WP_000949466.1\|2072840_2073341_+\|H-type-ferritin-FtnA	unknown	unknown	gnl\|CDD\|224445
NC_002952.2\|WP_000545373.1\|2079581_2081009_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NC_002952.2\|WP_000027924.1\|2081021_2082479_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NC_002952.2\|WP_001231458.1\|2077811_2078759_-\|diacylglycerol-kinase	unknown	unknown	gnl\|CDD\|183982
NC_002952.2\|WP_000544973.1\|2070502_2071234_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NC_002952.2\|WP_001165363.1\|2091059_2091362_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226893
NC_002952.2\|WP_000548777.1\|2075669_2076200_-\|DUF3267-domain-containing-protein	unknown	unknown	gnl\|CDD\|378690
NC_002952.2\|WP_000831691.1\|2084776_2085976_-\|CamS-family-sex-pheromone-protein	unknown	unknown	gnl\|CDD\|227188
NC_002952.2\|WP_000957023.1\|2083149_2084688_+\|sodium/proline-symporter-PutP	unknown	unknown	gnl\|CDD\|273981
NC_002952.2\|WP_000272063.1\|2090184_2090877_-\|heptaprenylglyceryl-phosphate-synthase	unknown	unknown	gnl\|CDD\|224560
NC_002952.2\|WP_000992926.1\|2087995_2090188_-\|DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|273429
NC_002952.2\|WP_001790679.1\|2073422_2073515_-\|hypothetical-protein	unknown	unknown	unknown
NC_002952.2\|WP_001791535.1\|2079396_2079543_-\|hypothetical-protein	unknown	unknown	unknown
NC_002952.2\|WP_000170162.1\|2082480_2082783_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NC_002952.2\|WP_001790257.1\|2070306_2070417_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_002952.2\|WP_000774552.1\|2085988_2087992_-\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NC_002952.2\|WP_001147874.1\|2076369_2077731_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	0
NC_002952.2\|WP_000613738.1\|2073731_2074286_+\|3'-5'-exonuclease	gnl\|CDD\|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	4.39188e-75
NC_002952.2\|WP_000140179.1\|2074352_2075423_-\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
NC_002952.2\|WP_001250339.1\|2071235_2072549_-\|lipid-II-isoglutaminyl-synthase-subunit-MurT	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	3.60835e-98
NC_002952.2\|WP_000949466.1\|2072840_2073341_+\|H-type-ferritin-FtnA	gnl\|CDD\|224445	COG1528, Ftn, Ferritin-like protein [Inorganic ion transport and metabolism].	1.15329e-74
NC_002952.2\|WP_000545373.1\|2079581_2081009_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NC_002952.2\|WP_000027924.1\|2081021_2082479_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NC_002952.2\|WP_001231458.1\|2077811_2078759_-\|diacylglycerol-kinase	gnl\|CDD\|183982	PRK13337, PRK13337, putative lipid kinase; Reviewed.	0
NC_002952.2\|WP_000544973.1\|2070502_2071234_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	1.79354e-120
NC_002952.2\|WP_000272063.1\|2090184_2090877_-\|heptaprenylglyceryl-phosphate-synthase	gnl\|CDD\|224560	COG1646, COG1646, Predicted phosphate-binding enzymes, TIM-barrel fold [General function prediction only].	2.53994e-99
NC_002952.2\|WP_000831691.1\|2084776_2085976_-\|CamS-family-sex-pheromone-protein	gnl\|CDD\|227188	COG4851, CamS, Protein involved in sex pheromone biosynthesis [General function prediction only].	0
NC_002952.2\|WP_001165363.1\|2091059_2091362_-\|hypothetical-protein	gnl\|CDD\|226893	COG4496, COG4496, Uncharacterized protein conserved in bacteria [Function unknown].	1.66593e-59
NC_002952.2\|WP_000992926.1\|2087995_2090188_-\|DNA-helicase-PcrA	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_002952.2\|WP_000548777.1\|2075669_2076200_-\|DUF3267-domain-containing-protein	gnl\|CDD\|378690	pfam11667, DUF3267, Putative zincin peptidase. This family of proteins has a conserved HEXXH motif, suggesting the members are putative peptidases of zincin fold.	1.54005e-11
NC_002952.2\|WP_000957023.1\|2083149_2084688_+\|sodium/proline-symporter-PutP	gnl\|CDD\|273981	TIGR02121, Osmoregulated_proline_transporter, sodium/proline symporter. This family consists of the sodium/proline symporter (proline permease) from a number of Gram-negative and Gram-positive bacteria and from the archaeal genus Methanosarcina. Using the related pantothenate permease as an outgroup, candidate sequences from Bifidobacterium longum and several from archaea are found to be outside the clade defined by known proline permeases. These sequences, scoring between 570 and -40, define the range between trusted and noise cutoff scores. [Transport and binding proteins, Amino acids, peptides and amines].	0
NC_002952.2\|WP_000170162.1\|2082480_2082783_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	5.296e-34

>NC_002952.2|WP_001231458.1|2077811_2078759_-|diacylglycerol-kinase
MRKRARIIYNPTSGKEQFKRELPDALIKLEKAGYETSAYATEKIGDATLEAERAMHENYDVLIAAGGDGTLNEVVNGIAEKPNRPKLGVIPMGTVNDFGRALHIPNDIMGALDVIIEGHSTKVDIGKMNNRYFINLAAGGQLTQVSYETPSKLKSIVGPFAYYIKGFEMLPQMKAVDLRIEYDGNVFQGEALLFFLGLTNSMAGFEKLVPDAKLDDGYFTLIIVEKSNLAELGHIMTLASRGEHTKHPKVIYEKAKAINISSFTDLQLNVDGEYGGKLPANFLNLERHIDVFAPNDIVNEELINNDHVDDNLIEE
>NC_002952.2|WP_001147874.1|2076369_2077731_-|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MQAIAKNDIKTGTVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLLNINTRSENRVAPPCIYYERCGGCQLQHLSYEAQLEMKKEQVINLFQRKAHFDNSKINDTVGMTDPWRYRNKSQIPVGKNEQNEVIMGFYRQRSHDIIDMGSCLIQDSQHQEVMNEVKSILKDLNVSIYQEQLKKGLMRHLVVRTGYHTDEMMVIFVTNGKNWPQKNAVVEKILDAFPNVTSIKQNINDSHSNVIMGRQSITLYGKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAIEYAQLTGNEVVLDTYCGIGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWKAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIVYISCNPSTQQRDALLLAEKYQLEEVTPVDMFPQTTHVETVALFNLK
>NC_002952.2|WP_000548777.1|2075669_2076200_-|DUF3267-domain-containing-protein
MHKIDLTTNNFQMRRFIILQLVIALFVILFTYKWALGVTAVVDQNIIINLVYGFAGFIILLILHELIHRALFLLFKKDSKPMFNIKKDRILFQTADACFNKWQFSIIMLSPLILLSAGLLILIKVFGYSSLIFMFSMHTAYCFIDILLVALTISSSFKYVQQDEDSIYLYHQKPTQ
>NC_002952.2|WP_000140179.1|2074352_2075423_-|DNA-polymerase-IV
MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGMTVIDYRNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSTRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTYKNMTIYDFI
>NC_002952.2|WP_000613738.1|2073731_2074286_+|3'-5'-exonuclease
MIQDAFVALDFETANGKRTSICSVGMVKVIDSQITETFHTLVNPQDYFSQQNIKVHGIQPEDVENAPTFDYVFPYMMQFIADLPVVAHNAAFDMNVLHQSIQNIGLPTPNLTYFCSYQLAKRTVDSYRYGLKHMMEFYQLDFHGHHDALNDAKACAMITFRLLKNYENLTYVTNIYGKNLKDKG
>NC_002952.2|WP_001790679.1|2073422_2073515_-|hypothetical-protein
MTKNTIISLENEKTQINDSENESSDLRKAK
>NC_002952.2|WP_000949466.1|2072840_2073341_+|H-type-ferritin-FtnA
MLSKNLLEALNDQMNHEYFAAHAYMAMAAYCDKESYEGFANFFIQQAKEERFHGQKIYNYINDRGAHAEFRAVSAPKIDFSSILETFKDSLSQEQEVTRRFYNLSEIARQDKDYATISFLNWFLDEQVEEEAMFETHINYLTRIGDDSNALYLYEKELGTRTFDEE
>NC_002952.2|WP_001250339.1|2071235_2072549_-|lipid-II-isoglutaminyl-synthase-subunit-MurT
MRQWTAIHLAKLARKASRAVGKRGTDLPGQIARKVDTDILRKLAEQVDDIVFISGTNGKTTTSNLIGHTLKANNIQIIHNNEGANMAAGITSAFIMQSTPKTKIAVIEIDEGSIPRVLKEVTPSMMVFTNFFRDQMDRFGEIDIMVNNIAETISNKGIKLLLNGDDPFVSRLKIASDTIVYYGMKAHAHEFEQSTMNESRYCPNCGRLLQYDYIHYNQIGHYHCQCGFKREQAKYEISRFDVAPFLHLNINDEKYDMKIAGDFNAYNALAAYTVLRELGLNEQAIKNGFETYTSDNGRMQYFKKERKEAMINLAKNPAGMNASLSVGEQLEGEKVYVISLNDNAADGRDTSWIYDADFEKLSKQQIEAIIVTGTRAEELQLRLKLAEVEVPIIVERDIYKATAKTMDYKGFTVAIPNYTSLAPMLEQLNRSFEGGQS
>NC_002952.2|WP_000544973.1|2070502_2071234_-|type-1-glutamine-amidotransferase
MHELTIYHFMSDKLNLYSDIGNIIALRQRAKKRNIKVNVVEINETEGITFDECDIFFIGGGSDREQALATKELSKIKTPLKEAIEDGMPGLTICGGYQFLGKKYITPDGTELEGLGILDFYTESKTNRLTGDIVIESDTFGTIVGFENHGGRTYHNFGTLGHVTFGYGNNDEDKKEGIHYKNLLGTYLHGPILPKNYEITDYLLEKACERKGIPFEPKEIDNEAEKQAKQVLIDRANRQKKSR
>NC_002952.2|WP_001790257.1|2070306_2070417_-|hypothetical-protein
MDGNNQIDVCFFVLVNNYYTMSIYPRIINSNGDYAT
>NC_002952.2|WP_001791535.1|2079396_2079543_-|hypothetical-protein
MVADLDAIEGLFISIEVILLLTLFIVHVNGKNINFINALALIILRQTV
>NC_002952.2|WP_000545373.1|2079581_2081009_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MHFETVIGLEVHVELKTDSKMFSPSPAHFGAEPNSNTNVIDLAYPGVLPVVNKRAVDWAMRAAMALNMEIATESKFDRKNYFYPDNPKAYQISQFDQPIGENGYIDIEVDGETKRIGITRLHMEEDAGKSTHKGEYSLVDLNRQGTPLIEIVSEPDIRSPKEAYAYLEKLRSIIQYTGVSDVKMEEGSLRCDANISLRPYGQEKFGTKAELKNLNSFNYVRKGLEYEEKRQEEELLSGGEIGQETRRFDESTGKTILMRVKEGSDDYRYFPEPDIVPLYIDDAWKERVRQTIPELPDERKAKYVNELGLPAYDAHVLTLTKEMSDFFESTIEHGADVKLTSNWLMGGVNEYLNKNQVELLDTKLTPENLAGMIKLIEDGTMSSKIAKKVFPELAAKGGNAKQIMEDNGLVQISDEATLLKFVNEALDNNEQSVEDYKNGKGKAMGFLVGQIMKASKGQANPQLVNQLLKQELDKR
>NC_002952.2|WP_000027924.1|2081021_2082479_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MSIRYESVENLLTLIKDKKIKPSDVVKDIYDAIEETDPTIKSFLALDKENAIKKAQELDELQAKDQMDGKLFGIPMGIKDNIITNGLETTCASKMLEGFVPIYESTVMEKLHNENAVLIGKLNMDEFAMGGSTETSYFKKTVNPFDHKAVPGGSSGGSAAAVAAGLVPFSLGSDTGGSIRQPAAYCGVVGMKPTYGRVSRFGLVAFASSLDQIGPLTRNVKDNAIVLEAISGADANDSTSAPVDDVDFTSEIGKDIKGLKVALPKEYLGEGVADDVKEAVQNAVETLKSLGAVVEEVSLPNTKFGIPSYYVIASSEASSNLSRFDGIRYGYHSKEAHSLEELYKMSRSEGFGKEVKRRIFLGTFALSSGYYDAYYKKSQKVRTLIKNDFDKVFENYDVVVGPTAPTTAFNLGEEIDDPLTMYANDLLTTPVNLAGLPGISVPCGQSNGRPIGLQFIGKPFDEKTLYRVAYQYETQYNLHDVYEKL
>NC_002952.2|WP_000170162.1|2082480_2082783_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MTKVTREEVEHIANLARLQISPEETEEMANTLESILDFAKQNDSADTEGVEPTYHVLDLQNVLREDKAIKGIPQELALKNAKETEDGQFKVPTIMNEEDA
>NC_002952.2|WP_000957023.1|2083149_2084688_+|sodium/proline-symporter-PutP
MLTMGTALSQQVDANWQTYIMIAVYFLILIVIGFYGYKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGAYINYFVVAPRLRVYTELAGDAITLPDFFKNRLNDKNNVLKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAMKPTNLNLFKGLSFIGIISLFSWGLGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAYHIKLEDPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLVRGEEKAKTHQKEFVMVGRLSVLAVAIVAIAIAWNPNDTILNLVGNAWAGFGASFSPLVLFALYWKGLTRAGAVSGMVSGALVVIVWIAWIKPLAHINEIFGLYEIIPGFIVSVIVTYVVSKLTKKPGAFVETDLNKVRDIVREK
>NC_002952.2|WP_000831691.1|2084776_2085976_-|CamS-family-sex-pheromone-protein
MKRTLVLLITAIFILAACGNHKDDQAGKDNQKHNNSSNQVKEIATDKNVQGDNYRTLLPFKESQARGLLQDNMANSYNGGDFEDGLLNLSKEVFPTDKYLYQDGQFLDKKTINAYLNLKYTKREIDKMSEKDKKDKKANENLGLNPSHEGETDPEKIAEKSPAYLSNILEQDFYGGGDTKGKNIKGMTIGLAMNSVYYYKKEKDGPTFSKKLDDSEVKKQGKQMASEILSRLRENDDLKDIPIHFAIYKQSSEDSITPGEFITQATAEKSQTKLNEWHNINEKSALLPSSTAADYDENLNNNFKQFNDNLQSYFSNFTQAVGKVKFVDKKPQRLVVDLPIDYYGQAETIGITQYVTEQANKYFDKIDNYEIRIKDGNQPRALISKTKDDKEPQVHIYSN
>NC_002952.2|WP_000774552.1|2085988_2087992_-|NAD-dependent-DNA-ligase-LigA
MADLSSRVNELHDLLNQYSYEYYVEDNPSVPDSEYDKLLHELIKIEEEHPEFKTVDSPTVRVGGEAQASFNKVNHDTPMLSLGNAFNEDDLRKFDQRIREQIGNVEYMCELKIDGLAVSLKYVDGYFVQGLTRGDGTTGEDITENLKTIHAIPLKMKEPLNVEVRGEAYMPRRSFLRLNEEKEKNDEQLFANPRNAAAGSLRQLDSKLTAKRKLSVFIYSVNDFTDFNARSQSEALDELDKLGFTTNKNRARVSDIDGVLEYIEKWTSQRESLPYDIDGIVIKVNDLDQQDEMGFTQKSPRWAIAYKFPAEEVVTKLLDIELSIGRTGVVTPTAILEPVKVAGTTVSRASLHNEDLIHDRDIRIGDSVVVKKAGDIIPEVVRSIPERRPEDAVTYHMPTHCPSCGHELVRIEGEVALRCINPKCQAQLVEGLIHFVSRQAMNIDGLGTKIIQQLYQSELIKDVADIFYLTEEDLLPLDRMGQKKVDNLLAAIQQAKDNSLENLLFGLGIRHLGVKASQVLAEKYETIDRLLTVTEAELVEIHDIGDKVAQSVVTYLENEDIRALIQKLKDKHVNMIYKGIKTSDIEGHPEFSGKTIVLTGKLHQMTRNEASKWLASQGAKVTSSVTKNTDVVIAGEDAGSKLTKAQSLGIEIWTEQQFVDKQNELNS
>NC_002952.2|WP_000992926.1|2087995_2090188_-|DNA-helicase-PcrA
MNALLNHMNTEQSEAVKTTEGPLLIMAGAGSGKTRVLTHRIAYLLDEKDVSPYNVLAITFTNKAAREMKERVQKLVGDQAEVIWMSTFHSMCVRILRRDADRIGIERNFTIIDPTDQKSVIKDVLKNENIDSKKFEPRMFIGAISNLKNELKTPADAQKEATDYHSQMVATVYSGYQRQLSRNEALDFDDLIMTTINLFERVPEVLEYYQNKFQYIHVDEYQDTNKAQYTLVKLLASKFKNLCVVGDSDQSIYGWRGADIQNILSFEKDYPEANTIFLEQNYRSTKTILNAANEVIKNNSERKPKGLWTANTNGEKIHYYEAMTERDEAEFVIREIMKHQRNGKKYQDMAILYRTNAQSRVLEETFMKSNMPYTMVGGQKFYDRKEIKDLLSYLRIIANSNDDISLQRIINVPKRGVGPSSVEKVQNYALQNNISMFDALGEADFIGLSKKVTQECLNFYELIQSLIKEQEFLEIHEIVDEVLQKSGYREMLERENTLESRSRLENIDEFMSVPKDYEENTPLEEQSLINFLTDLSLVADIDEADTENGVTLMTMHSAKGLEFPIVFIMGMEESLFPHIRAIKSEGDHEMQEERRICYVAITRAEEVLYITHATSRMLFGRPQSNMPSRFLKEIPESLLENHSSGKRQTIQPKAKPFAKRGFSQRTTSTKKQVSSSDWNVGDKVMHKAWGEGMVSNVNEKNGSIELDIIFKSQGPKRLLAQFAPIEKKED
>NC_002952.2|WP_000272063.1|2090184_2090877_-|heptaprenylglyceryl-phosphate-synthase
MYDIKKWRHIFKLDPAKHISDDDLDAICMSQTDAIMIGGTDDVTEDNVIHLMSRVRRYPLPLVLEISNIESVMPGFDFYFVPTVLNSTDVAFHNGTLLEALKTYGHSIDFEEVIFEGYVVCNADSKVAKHTKANTDLTTEDLEAYAQMVNHLYRLPVMYIEYSGIYGDVSKVQAVSEHLTETQLFYGGGISSEQQATEMAAIADTIIVGDIIYKDIKKALKTVKIKESSK
>NC_002952.2|WP_001165363.1|2091059_2091362_-|hypothetical-protein
MQIEKLRGAALDELFDAILTLENREECYQFFDDLCTVNEIQSLSQRLQVAKMIKQGYTYATIEQESGASTATISRVKRSLQWGNDAYTMILDRMNIETNE

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Crispr_ID: NC_002952_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002952_6

2324693-2324894

Orphan

Consensus_repeat	Method
TCCTTGGTTGGCAGGTGCAGCTGGATGTGCTGTA	PILER-CR

2 spacers

The CRISPR arrays of NC_002952_6

>merge|NC_002952|6|2324693-2324894|PILER-CR
TGCTTGGTTGGCAGGTGCTGCTTGATTTCCAGGTTGTGCTTGTGCAGCGTTATTCGGATCAGCTTGATTACCTTGTCCAGCTGGTTGTGCTGTACCTGCTGCCGGTTGTGCTGCGCCTCCTGCTGGATTAGCCTGTCCACCTTGGTTTGCTGGTTGTGCTGCTGGTTGTCCTTGGTTGGCAGGTGCAGCTGGCTGTGCTGTA

>NC_002952|6|1|2324693-2324894|PILER-CR
TGCTTGGTTGGCAGGTGCTGCTTGATTTCCAGGT	TGTGCTTGTGCAGCGTTATTCGGATCAGCTTGATTACCTTGTCCAGCT
GGTTGTGCTGTACCTGCTGCCGGTTGTGCTGCGC	CTCCTGCTGGATTAGCCTGTCCACCTTGGTTTGCTGGTTGTGCTGCTGGTTGTCCTTGGTTGGCAGGTGCAGCT
GGCTGTGCTGTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_002952.2\|WP_001237527.1\|2341185_2342529_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_002952.2\|WP_000370937.1\|2307710_2308568_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NC_002952.2\|WP_000648736.1\|2316286_2317393_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NC_002952.2\|WP_000908186.1\|2308635_2309418_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_002952.2\|WP_001792784.1\|2306893_2307052_+\|hypothetical-protein	unknown	unknown	unknown
NC_002952.2\|WP_000047120.1\|2342706_2343390_-\|hemolysin-III-family-protein	unknown	unknown	gnl\|CDD\|224191
NC_002952.2\|WP_000495684.1\|2302657_2303749_+\|hypothetical-protein	unknown	unknown	unknown
NC_002952.2\|WP_000162591.1\|2330621_2331530_-\|arginase	unknown	unknown	gnl\|CDD\|212515
NC_002952.2\|WP_001292150.1\|2315852_2316287_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NC_002952.2\|WP_000927367.1\|2313708_2315841_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_002952.2\|WP_073392962.1\|2306109_2306214_-\|hypothetical-protein	unknown	unknown	unknown
NC_002952.2\|WP_000521495.1\|2327306_2328662_-\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237670
NC_002952.2\|WP_000334466.1\|2309649_2311455_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_002952.2\|WP_000958522.1\|2337746_2338811_-\|P-loop-NTPase	unknown	unknown	gnl\|CDD\|378455
NC_002952.2\|WP_000884730.1\|2343408_2344596_-\|UDPGP-type-1-family-protein	unknown	unknown	gnl\|CDD\|133036
NC_002952.2\|WP_072435031.1\|2340590_2341064_-\|multidrug-efflux-transporter-SepA	unknown	unknown	gnl\|CDD\|374975
NC_002952.2\|WP_000083795.1\|2312135_2313674_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NC_002952.2\|WP_000277741.1\|2325363_2327010_-\|IS1182-like-element-ISSau3-family-transposase	unknown	unknown	gnl\|CDD\|226192
NC_002952.2\|WP_000347896.1\|2329622_2330432_-\|TIGR00159-family-protein	unknown	unknown	gnl\|CDD\|224539
NC_002952.2\|WP_000894028.1\|2328688_2329621_-\|YbbR-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|227193

Protein	Function_ID	Function_description	E-value
NC_002952.2\|WP_001237527.1\|2341185_2342529_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.31901e-37
NC_002952.2\|WP_000370937.1\|2307710_2308568_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.15818e-59
NC_002952.2\|WP_000648736.1\|2316286_2317393_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NC_002952.2\|WP_000908186.1\|2308635_2309418_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.75723e-107
NC_002952.2\|WP_000047120.1\|2342706_2343390_-\|hemolysin-III-family-protein	gnl\|CDD\|224191	COG1272, COG1272, Predicted membrane protein, hemolysin III homolog [General function prediction only].	4.64044e-66
NC_002952.2\|WP_001292150.1\|2315852_2316287_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	6.01856e-62
NC_002952.2\|WP_000162591.1\|2330621_2331530_-\|arginase	gnl\|CDD\|212515	cd09989, Arginase, Arginase family. This family includes arginase, also known as arginase-like amidino hydrolase family, and related proteins. Arginase is a binuclear Mn-dependent metalloenzyme and catalyzes hydrolysis of L-arginine to L-ornithine and urea (Arg, EC 3.5.3.1), the reaction being the fifth and final step in the urea cycle, providing the path for the disposal of nitrogenous compounds. Arginase controls cellular levels of arginine and ornithine which are involved in protein biosynthesis, and in production of creatine, polyamines, proline and nitric acid. In vertebrates, at least two isozymes have been identified: type I (ARG1) cytoplasmic or hepatic liver-type arginase and type II (ARG2) mitochondrial or non-hepatic arginase. Point mutations in human arginase ARG1 gene lead to hyperargininemia with consequent mental disorders, retarded development and early death. Hyperargininemia is associated with a several-fold increase in the activity of the mitochondrial arginase (ARG2), causing persistent ureagenesis in patients. ARG2 overexpression plays a critical role in the pathophysiology of cholesterol mediated endothelial dysfunction. Thus, arginase is a therapeutic target to treat asthma, erectile dysfunction, atherosclerosis and cancer.	5.94976e-145
NC_002952.2\|WP_072435031.1\|2340590_2341064_-\|multidrug-efflux-transporter-SepA	gnl\|CDD\|374975	pfam17080, SepA, Multidrug Resistance efflux pump. SepA is a drug efflux protein that is involved in bacterial multidrug resistance. It is predicted to have four transmembrane domains.	1.1244e-29
NC_002952.2\|WP_000927367.1\|2313708_2315841_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	9.39374e-67
NC_002952.2\|WP_000083795.1\|2312135_2313674_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NC_002952.2\|WP_000521495.1\|2327306_2328662_-\|phosphoglucosamine-mutase	gnl\|CDD\|237670	PRK14316, glmM, phosphoglucosamine mutase; Provisional.	0
NC_002952.2\|WP_000334466.1\|2309649_2311455_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_002952.2\|WP_000958522.1\|2337746_2338811_-\|P-loop-NTPase	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	5.47694e-116
NC_002952.2\|WP_000884730.1\|2343408_2344596_-\|UDPGP-type-1-family-protein	gnl\|CDD\|133036	cd04193, UDPGlcNAc_PPase, UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylase (UAP) (also named GlcNAc1P uridyltransferase), catalyzes the reversible conversion of UTP and GlcNAc1 to PPi and UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc), the activated form of GlcNAc, is a key precursor of N- and O-linked glycosylations. It is essential for the synthesis of chitin (a major component of the fungal cell wall) and of the glycosylphosphatidylinositol (GPI) linker which anchors a variety of cell surface proteins to the plasma membrane. In bacteria, UDPGlcNAc represents an essential precursor for both peptidoglycan and lipopolysaccharide biosynthesis. Human UAP has two isoforms, resulting from alternative splicing of a single gene and differing by the presence or absence of 17 amino acids. UDPGlcNAc pyrophosphorylase shares significant sequence and structure conservation with UDPglucose pyrophosphorylase.	9.19785e-146
NC_002952.2\|WP_000277741.1\|2325363_2327010_-\|IS1182-like-element-ISSau3-family-transposase	gnl\|CDD\|226192	COG3666, COG3666, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.77139e-37
NC_002952.2\|WP_000347896.1\|2329622_2330432_-\|TIGR00159-family-protein	gnl\|CDD\|224539	COG1624, COG1624, Uncharacterized conserved protein [Function unknown].	2.13611e-103
NC_002952.2\|WP_000894028.1\|2328688_2329621_-\|YbbR-like-domain-containing-protein	gnl\|CDD\|227193	COG4856, COG4856, Uncharacterized protein conserved in bacteria [Function unknown].	4.21538e-117

>NC_002952.2|WP_000648736.1|2316286_2317393_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALATGHQYDVILADESKTTTRVNNVAAINSMQPSEELKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLAYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS
>NC_002952.2|WP_001292150.1|2315852_2316287_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEGNVDRIVQAKSAEEIKQVFEEADA
>NC_002952.2|WP_000927367.1|2313708_2315841_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRITGADSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNLAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVKKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETRDKSSNMIDKDDVHIETKDIDGNTSFENEQTSYLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFIPDNDFMASLISDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NC_002952.2|WP_000083795.1|2312135_2313674_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWFPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFFGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLATLVSFVVAALIMKFTKEPKQDLEAATAQMETTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSLDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NC_002952.2|WP_000334466.1|2309649_2311455_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVTLQLISYYAALHRDLDVDKPRNLAKSVTVE
>NC_002952.2|WP_000908186.1|2308635_2309418_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINEGDKWILYGLNGAGKTTLLNILNAYEPATTGYVNLFGKMPGKVGYSTETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEVRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NC_002952.2|WP_000370937.1|2307710_2308568_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLREKGYKVFLATGRSHSEIHQLVPEDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIEHFGINQKETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NC_002952.2|WP_001792784.1|2306893_2307052_+|hypothetical-protein
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>NC_002952.2|WP_073392962.1|2306109_2306214_-|hypothetical-protein
MLLLERTSMSDFEMLMIVLTIIGLVLISTQDHKK
>NC_002952.2|WP_000495684.1|2302657_2303749_+|hypothetical-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLVGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLVIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVITIILFVVIHAVILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NC_002952.2|WP_000277741.1|2325363_2327010_-|IS1182-like-element-ISSau3-family-transposase
MYKNYNMTQLTLPIETSVRIPQNDISRYVNEIVETIPDSEFDEFRHHRGATSYHPKMMLKIILYAYTQSVFSGRRIEKLLHDSIRMMWLAQNQTPSYKTINRFRVNPNTDALIESLFIQFHSQCLKQNLIDDNSIFIDGTKVEANANRYTFVWKKSIQNHESKLNENSKALYRDLVEEKIIPEIKEDGDSDLTIEEIDLIGSHLDKEIEDLNHSIQNEDCTQIRKQTRKKRTEIKKFKKKFDDYSERKSKYEEQKSILKDRNSFSKTDHDATFMRMKEDHMKNGQLKPGYNLQIATNSQFVLSYDLFQNPTDTRTLIPFLTMIQNTFGYLPEYIVADAGYGSEQNYMAIIDDFNKTPLITYGMFIKDKTRKFKSDIFNTQNWKYDELNDEFICPNNKRIGFKRYAYRNDRYGFKRDFKLYECDDCSACSLRQQCMKPNSKSNKKIMKNYNWEYFKAQINQKLSEPETKKIYSQRKIDVEPVFGFMKAILGFTRMSVRGINKVKRELGFVLMALNIRKIVARRAVYYQIHLKKADFYQIINRNQLFYIA
>NC_002952.2|WP_000521495.1|2327306_2328662_-|phosphoglucosamine-mutase
MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLESALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFKLSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIVLDGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLAFDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEGIKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKSLSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLVRVMVEAATDEDAERFAQQIADVVQDKMGLDK
>NC_002952.2|WP_000894028.1|2328688_2329621_-|YbbR-like-domain-containing-protein
MLESKWGLRFIAFLLALFFFLSVNNVFGNIFNTGNLGQKSSKTIQDVPVEILYNTKDLHLTKAPETVNVTISGPQSKIIKIENPEDLRVVIDLSNAKAGKYQEKYQVKGLADDIHYSVKPKLANITLENKVTKKMTVQPDVSQSDIDPLYKITKQEVSPQTVKITGGEEQLNDIAYLKATFKTNKKINGDTKDIAEVTAFDKKLNKLNVSIQPNEVNLQVKVEPFSKKVKVNVKQKGSLADDKELSSIDLEDKEIEIFGSRDDLQNISEVDAEVDLDGISESTEKTVKINLPEHVSKAEPSETKAYINVK
>NC_002952.2|WP_000347896.1|2329622_2330432_-|TIGR00159-family-protein
MDFSNFFQNLSTLKIVTSILDLLIVWYVLYLLITVFKGTKAIQLLKGILVIVIGQQISMILNLTATSKLFDIVIQWGVLALIVIFQPEIRRALEQLGRGSFLKRYTSNTYSKDEEKLIQSVSKAVQYMAKRRIGALIVFEKETGLQDYIETGIAMDSNISQELLINVFIPNTPLHDGAMIIQGTKIAAAASYLPLSDSPKISKSLGTRHRAAVGISEVSDAFTVIVSEETGDISVTFDGKLRRDISNEIFEELLAEHWFGTRFQKKGVK
>NC_002952.2|WP_000162591.1|2330621_2331530_-|arginase
MTKKKGIDIIGVPSTFGQRKLGVDLGPTAIRYAGLIPRLKQLDLDVNDKGDIKVSAVDIEKFQSEQNGLRNYDEIIDVTQKLNKEVSASIENNRFPLVLGGDHSIAIGSVSAISKHYNNLGVIWYDAHGDLNIPEESPSGNIHGMPLRILTGEGPKELLELNSNVIKPENIVLIGMRDLDKGERQFIKDHNIKTFTMSDIDKLGIKEVIENTIEYLKSRNVDGVHLSLDVDALDPLETPGTGTRVLGGLTYRESHFALELLHQSQSVTSMDLVEVNPLIDHNNHTAEQSVSLVGTFFGETLL
>NC_002952.2|WP_000958522.1|2337746_2338811_-|P-loop-NTPase
MLTVDQVKELIGEIKDPIIDVPLKETEGIVEVSIKEEKEHVSVKVAMAQLGGAPQLDLQMAVVNVLKENGAKTVGIRFETLPEEKVNQFKPKEENKPKTIEGLLSQNNPVEFIAIASGKGGVGKSTVAVNLAVALAREGKKVGLVDADIYGFSVPDMMGIDEKPGINGKEVIPVERHGVKVISMAFFVEENAPVIWRGPMLGKMLTNFFTEVRWGDIEYLILDLPPGTGDVALDVHTMLPSSKEIIVTTPHPTAAFVAARAGAMAKHTDHSILGVIENMSYFESKETGNKEYVFGKGGGTKLADELNTQLLGELPLEQPSWNPKDFAPSIYQSDDRLGKIYSSIAQKVIAATNK
>NC_002952.2|WP_072435031.1|2340590_2341064_-|multidrug-efflux-transporter-SepA
MVMNYLKHKFYNLLTTIIVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMYDNLLYYGSYIIFGYFIVFAVEHLMDYFRKMLPENAYFRGATFHLISYMVATTLFYFIIHLNYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
>NC_002952.2|WP_001237527.1|2341185_2342529_-|MFS-transporter
MRLKSIVTVIALILIMFMAAIESSIISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLSTHFSMLVISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIAIILVVWTFHFPEEETVAKSKFDTKGITLFYIFIGLIMFALLNQQHLYLNIIGFVLAILVALRLFNVEKKVSSPFLPVAEFNRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRKVIYLSSFTLLLLSSIIIAFGIKLPILIACVLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTIMGYLYALKSGLFGANLHNILGVVSLISVGLIVVWLIFYREAASQTKE
>NC_002952.2|WP_000047120.1|2342706_2343390_-|hemolysin-III-family-protein
MSKSSEKSNDTIVETFKDIIPLSFGEEIGNAASHGVAALLTLLVLPYAAVHSYIAYGTLASVSMSIYVISIFMMFISSTIYHSMQNETPHKYILRIIDHSMIYVAISGTYTPILLTVVGGWIGWTVFILLWGTTLWGILYKSIAVKVNQKLSLIVYLVMGWVGIILLPIIFIRTSWIFILFIFLGGVSYTIGAWFYAQKNRPYFHMIWHIFIVIASLLHLIAILYFM
>NC_002952.2|WP_000884730.1|2343408_2344596_-|UDPGP-type-1-family-protein
MLDKNQLAKYKQDHLCEYEKIMSNNEKEALEEKVASLDLDFIAKLYNDLYINKKTIDDVSAVSEVKYDIKSQMSDDEIKRLEEQGLQAIKEGQFAVLLMAGGQGTRLGYKGPKGSFEIEGVSLFELQAKQLKELHRQTGHKIQWYIMTSDINHEETLAYFESHNYFGYDQESIHFFKQDNIVALSEAGQLILNQQGRIMETPNGNGGVFKSLDKAGYLEEMSNNGVKYIFLNNIDNVLVKVLDPLFAGFTVEHDYDITSKTIQPKPGESVGRLVNVDCKDTVLEYSELDPEVANQFNNANIGIHAFKLGFILNAVNRELPYHLAIKNLKQLDENFGVIEQPTLKFELFYFDIFTYGTSFVTLQVPREEEFSPLKNKEGKDSVATATEDLRRMGLI

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Crispr_ID: NC_002952_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002952_7

2385150-2385275

Orphan

Consensus_repeat	Method
CCTCTTTACTCGAAAGCTCACAAAACTCTTGATATCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_002952_7

>merge|NC_002952|7|2385150-2385275|CRISPRCasFinder
CCTCTTTACTCGAAAGCTCACAAAACTCTTGATATCACTGGTTTCTCATGATTTTTTAATGTTTTTATTTTGAGTTACTCGAAAATTTTCCTCTTTACTCGAAAGCTCACAAAACCCTTGATATCA

>NC_002952|7|5|2385150-2385275|CRISPRCasFinder
CCTCTTTACTCGAAAGCTCACAAAACTCTTGATATCA	CTGGTTTCTCATGATTTTTTAATGTTTTTATTTTGAGTTACTCGAAAATTTT
CCTCTTTACTCGAAAGCTCACAAAACCCTTGATATCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_002952.2\|WP_000769709.1\|2380381_2380807_+\|MAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|367591
NC_002952.2\|WP_000179061.1\|2381197_2381902_-\|acetolactate-decarboxylase	unknown	unknown	gnl\|CDD\|226058
NC_002952.2\|WP_094409958.1\|2391852_2393420_+\|IS3-like-element-ISSau2-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_002952.2\|WP_000569649.1\|2394057_2395002_-\|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl\|CDD\|235359
NC_002952.2\|WP_000136272.1\|2384904_2385084_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236623
NC_002952.2\|WP_000204271.1\|2385332_2386769_-\|putative-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225420
NC_002952.2\|WP_000791607.1\|2389014_2389821_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NC_002952.2\|WP_001250038.1\|2387529_2387967_-\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NC_002952.2\|WP_000586768.1\|2389810_2390671_-\|energy-coupling-factor-transporter-ATPase	unknown	unknown	gnl\|CDD\|184205
NC_002952.2\|WP_000850000.1\|2374897_2375314_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133384
NC_002952.2\|WP_000044369.1\|2379271_2380087_-\|HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319792
NC_002952.2\|WP_000170975.1\|2387117_2387516_-\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NC_002952.2\|WP_001044451.1\|2378206_2379061_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NC_002952.2\|WP_000389651.1\|2390667_2391477_-\|energy-coupling-factor-transporter-ATPase	unknown	unknown	gnl\|CDD\|184207
NC_002952.2\|WP_001221836.1\|2388215_2389010_-\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NC_002952.2\|WP_000222271.1\|2375720_2378147_+\|polysaccharide-lyase-8-family-protein	unknown	unknown	gnl\|CDD\|238517
NC_002952.2\|WP_001791584.1\|2384072_2384255_-\|hypothetical-protein	unknown	unknown	unknown
NC_002952.2\|WP_000542274.1\|2393672_2394041_-\|50S-ribosomal-protein-L17	unknown	unknown	gnl\|CDD\|235522
NC_002952.2\|WP_001791582.1\|2375556_2375724_+\|hypothetical-protein	unknown	unknown	unknown
NC_002952.2\|WP_000130145.1\|2381938_2383603_-\|acetolactate-synthase-AlsS	unknown	unknown	gnl\|CDD\|236312

Protein	Function_ID	Function_description	E-value
NC_002952.2\|WP_000769709.1\|2380381_2380807_+\|MAP-domain-containing-protein	gnl\|CDD\|367591	pfam03642, MAP, MAP domain. This presumed 110 amino acid residue domain is found in multiple copies in MAP (MHC class II analogue protein). The protein has been found in a wide range of extracellular matrix proteins.	8.17372e-34
NC_002952.2\|WP_000179061.1\|2381197_2381902_-\|acetolactate-decarboxylase	gnl\|CDD\|226058	COG3527, AlsD, Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism].	1.39507e-119
NC_002952.2\|WP_094409958.1\|2391852_2393420_+\|IS3-like-element-ISSau2-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.59839e-44
NC_002952.2\|WP_000569649.1\|2394057_2395002_-\|DNA-directed-RNA-polymerase-subunit-alpha	gnl\|CDD\|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	1.89947e-175
NC_002952.2\|WP_000136272.1\|2384904_2385084_-\|hypothetical-protein	gnl\|CDD\|236623	PRK09775, PRK09775, type II toxin-antitoxin system HipA family toxin YjjJ.	0.0004492
NC_002952.2\|WP_001250038.1\|2387529_2387967_-\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	4.91074e-100
NC_002952.2\|WP_000791607.1\|2389014_2389821_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	2.81787e-49
NC_002952.2\|WP_000204271.1\|2385332_2386769_-\|putative-DNA-binding-domain-containing-protein	gnl\|CDD\|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	3.62307e-63
NC_002952.2\|WP_000850000.1\|2374897_2375314_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133384	cd01109, HTH_YyaN, Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB. Putative helix-turn-helix (HTH) MerR-like transcription regulators of Bacillus subtilis, YyaN and YraB, and related proteins; N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	5.51415e-41
NC_002952.2\|WP_000044369.1\|2379271_2380087_-\|HAD-IIB-family-hydrolase	gnl\|CDD\|319792	cd02605, HAD_SPP, sucrose-phosphatase, similar to Synechocystis sp PCC 6803 SPP. Sucrose-phosphatase (SPP; EC 3.1.3.24) catalyzes the dephosphorylation of sucrose-6(F)-phosphate (Suc6P)-the final step in the pathway of sucrose biosynthesis in plants and cyanobacteria. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.06188e-100
NC_002952.2\|WP_000170975.1\|2387117_2387516_-\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	2.2295e-82
NC_002952.2\|WP_000586768.1\|2389810_2390671_-\|energy-coupling-factor-transporter-ATPase	gnl\|CDD\|184205	PRK13646, cbiO, energy-coupling factor transporter ATPase.	0
NC_002952.2\|WP_000389651.1\|2390667_2391477_-\|energy-coupling-factor-transporter-ATPase	gnl\|CDD\|184207	PRK13648, cbiO, cobalt transporter ATP-binding subunit; Provisional.	0
NC_002952.2\|WP_001221836.1\|2388215_2389010_-\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	1.21958e-120
NC_002952.2\|WP_000222271.1\|2375720_2378147_+\|polysaccharide-lyase-8-family-protein	gnl\|CDD\|238517	cd01083, GAG_Lyase, Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen. These are broad-specificity glycosaminoglycan lyases which recognize uronyl residues in polysaccharides and cleave their glycosidic bonds via a beta-elimination reaction to form a double bond between C-4 and C-5 of the non-reducing terminal uronyl residues of released products. Substrates include chondroitin, chondroitin 4-sulfate, chondroitin 6-sulfate, and hyaluronic acid. Family members include chondroitin AC lyase, chondroitin abc lyase, xanthan lyase, and hyalurate lyase.	0
NC_002952.2\|WP_001044451.1\|2378206_2379061_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.20929e-22
NC_002952.2\|WP_000542274.1\|2393672_2394041_-\|50S-ribosomal-protein-L17	gnl\|CDD\|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	2.70058e-62
NC_002952.2\|WP_000130145.1\|2381938_2383603_-\|acetolactate-synthase-AlsS	gnl\|CDD\|236312	PRK08617, PRK08617, acetolactate synthase AlsS.	0

>NC_002952.2|WP_000136272.1|2384904_2385084_-|hypothetical-protein
MTEIVEFLSDGKLASRLEIQETMGLQKSYTSELIAELKKLEIIGSEGRGPGTRYYLIRD
>NC_002952.2|WP_001791584.1|2384072_2384255_-|hypothetical-protein
MIDSVFWKKAFIPVYFIVAMLVFLLFRFYIKTNNFSIYLMIIFLMCLGTASIIYNYKNNR
>NC_002952.2|WP_000130145.1|2381938_2383603_-|acetolactate-synthase-AlsS
MTDKKYTAADMVIDTLKNNGVEYVFGIPGAKIDYLFNALIDDGPELIVTRHEQNAAMMAQGIGRLTGKPGVVLVTSGPGVSNLTTGLLTATSEGDPVLALGGQVKRNDLLRLTHQSIDNAALLKYSSKYSEEVQDPESLSEVMTNAIRIATSGKNGASFISIPQDVISSPVESKAISLCQKPNLGVPSEQDINDVIEAIKNASFPVLLAGMRSSSADETNAIRKLVERTNLPVVETFQGAGVISRELENHFFGRVGLFRNQVGDELLRKSDLVVTIGYDPIEYEASNWNKELETQIINIDEVQAEITNYMQPKKELIGNIAKTIEMISEKVDEPFINQQHLDELEQLRTHIDEETGIKATHEEGILHPVEIIESMQKVLTDDTTVTVDVGSHYIWMARNFRSYNPRHLLFSNGMQTLGVALPWAISAALVRPNTQVVSVAGDGGFLFSSQDLETAVRKNLNIIQLIWNDGKYNMVEFQEEMKYKRSSGVDFGPVDFVKYAESFGAKGLRVTNQEELEAAIKEGYETDGPVLIDIPVNYKDNIKLSTNMLPDVFN
>NC_002952.2|WP_000179061.1|2381197_2381902_-|acetolactate-decarboxylase
MASVLYQHGTLGTLMAGLLKGTASINELLQHGDLGIATLTGSNGEVIFLDGKAYHANEHKEFVELKGDELTPYATVTKFVADTSYETKDKSSEAVFAEIKEKMLSENLFSAVKISGLFKKMHVRMMPAQEPPYTRLIDSARRQPEQTETYVKGAVVGFFTPELFHGIGSAGFHVHFANDDRNFGGHVLDFEVEDVKVEIQNIETFEQHFPIQDEDFINANIDYKDIADEIREAE
>NC_002952.2|WP_000769709.1|2380381_2380807_+|MAP-domain-containing-protein
MKLKSFVTATLALGLLSTVGAALPSHEASADSNNGYKEMTMDGYHTVPYTISVDGITALHRTYFVFPENKKVLYQEIDSKVKNQLASQRGVTTEKINNAQTATYTLTLNDGNKKVVNLKKNDDAKNSIDPSTIKQIQIVVK
>NC_002952.2|WP_000044369.1|2379271_2380087_-|HAD-IIB-family-hydrolase
MSKRLLLFDFDETYFKHNTNEEDLSHLREMEKLLEKLTNNNEVITVVLTGSTFQSVMDKMDQVNMTFKPLHIFSDLSSKMFTWNNGEYVESETYKKKVLSEPFLFEDIEDILHHISAQYNVEFIPQRAFEGNETHYNFYFHSTGNHNNDRRILEVLVRYANDQNYTARFSRSNPLAGDPENAYDIDFTPSNAGKLYATQFLMKKYNIPVKSILGFGDSGNDEAYLSYLEHAYLMSNSRDEALKQKFRLTKYPYYQGITLHVKEFVEGKYDY
>NC_002952.2|WP_001044451.1|2378206_2379061_-|M23-family-metallopeptidase
MNKTNFGDYLNKSKSRKIYKIFDQNLKREFSYWQFRKLFKSYTWQSDVHELKVCTQNDGTIEQIWIDKANQFGVAVTWKDNSIIGFVMRPLINYDAIKNETTLKYAVPTTDCYEVFWGGDNELYNYHYLYPHQRYAIDLVIKENHKTYKNLGKVNADYFCFGKDIIAPANGTVEKVVNGVQDNSIGSTKESQFLGNYIVIKHAENEYSLIAHLQQYSIIVNEGQNVKYGDIIGKVGNSGNSTEPHIHFQVMNDKNIEACTSLKIRFINNRELIKGDVVCGLQGE
>NC_002952.2|WP_000222271.1|2375720_2378147_+|polysaccharide-lyase-8-family-protein
MTYRMKKWQKLSTITLLMAGVITLNGGEFRSIDKHQIAVADTNVQTTDYEKLRNIWLDVNYGYDKYDENNPDMKKKFEATENEAEKLLKEMKTESDRKYLWESSKDLDTKSADMTRTYRNIEKISEAMKHKNTKLKTDENKTKVKDALEWLHKNAYGKEPDKKVADLTSNFKNKTSRNTNLNWWDYEIGTPRALTNTLILLQEDFTDEEKKKYTAPIKTFAPDSDKILSSVGKSEPAKGGNLVDISKVKLLESIIEEDKDMMKKSIDSFNTVFTYAQNSATGKERNGFYKDGSYIDHQDVPYTGAYGVVLLEGISQMMPMIKETPFNDSNQNDTTLKSWIDDGFMPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDTMDKSTKAKYKKIVKTSVESDSSYKQTDYLSSYSDISKMKSLMEDSTISTNGLTQQLKIYNDMDRVTYHNKGLDFAFGLSMTSKNVARYESINGENLKGWHTGAGMSYLYNSDVKHYRDNFWATADMKRLAGTTTLDNEEPKSTDVKKSSKTFVGGTKFDDQHASIGMDFENQDKTLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRKANDYKLYKDDTQTTNSDNQETNSLFLESTNSTQNNIGYHFLNESKITVKKESHTGKWSDINKSQKDIQKTDEYYEVTQKHSNTDSKYAYVLYPGLSKDVFKSKASKVTVVKQEDDFHVVKDNESVWAGINYSDSAKTFEINNTKVEVKAKGMFILTKKDDNTYECSFYNPESTNSVSDIESKISMTGYSIINKNTSTSNESGVRFELTK
>NC_002952.2|WP_001791582.1|2375556_2375724_+|hypothetical-protein
MLKIWVIDCLYASTFFVDCLTVDSQLYTLTNFEKLNHYLIIIFIAHAQHKKETCQ
>NC_002952.2|WP_000850000.1|2374897_2375314_-|MerR-family-transcriptional-regulator
MKTKEVVALMNISQDTLRYYEKVGVIPPVNRDENGYRIYNDNDLNWIYLVKNLRNAGVSIESLIEFCRLAQLPKNENIQAQQKQILNKQLEELNENLKTIHDARDLLQYKIDNYDNHIAKINASDNHDDNVERLWERK
>NC_002952.2|WP_000204271.1|2385332_2386769_-|putative-DNA-binding-domain-containing-protein
MTSSKYIEYLQTEVEGQLLDRKRASINPKDVAQHISAFANAEGGKLVIGIEDNGEISGFNHSKAKKKEVYIEAPFEHLYRIPKYTYEIIEVKKRDGTMDEILIFDIEPSYDAIITLKDDSVYLRINDKSRKLTHNQITNLEYDRGSRRFEEELVEYSSIEDVNEELVDEFKQLLNTNVDNEKLLKARGFMREGKLTVAGLLLFSNHINVYLPGARIRFMRYEGTKEESGTRLNIVKDITFDKALPVAIREARAFINTQLREYTFLGKEGRFVTLPEYPEFAWFEGMINSIVHRRYDNQGDHIRIKMFDDRLEISSPGALPASVTLENIKEERYSRNPKLAAALTQYKWVRESNEGVGRIFDEMKQYFLDDPVYSEPNNSSVQLALKNNIIARKKRETGRVSNIITPELFESLNEQQELIVRHLYNQGELTASKIANIIQRSVPTARKRLKELEEMNIISTHGSSKNDPKRTYYLLGFE
>NC_002952.2|WP_000170975.1|2387117_2387516_-|30S-ribosomal-protein-S9
MTLAQVEYRGTGRRKNSVARVRLVPGEGNITVNNRDVREYLPFESLILDLNQPFDVTETKGNYDVLVNVHGGGFTGQAQAIRHGIARALLEADPEYRGSLKRAGLLTRDPRMKERKKPGLKAARRSPQFSKR
>NC_002952.2|WP_001250038.1|2387529_2387967_-|50S-ribosomal-protein-L13
MRQTFMANESNIERKWYVIDAEGQTLGRLSSEVASILRGKNKVTYTPHVDTGDYVIVINASKIEFTGNKETDKVYYRHSNHPGGIKSITAGELRRTNPERLIENSIKGMLPSTRLGEKQGKKLFVYGGAEHPHAAQQPENYELRG
>NC_002952.2|WP_001221836.1|2388215_2389010_-|tRNA-pseudouridine(38-40)-synthase-TruA
MRILVEIAYQGNNFLGFQIQQNGRTVQQQFEKLLQRIHKRHVRIHPSSRTDRGVHAIQQYFHFDTDLNIPMSQWQYAMNRTLPDDIYVNNVVTVDDDFHCRYDCVGKRYRYKVYQAQQRDPFQSGLKTFIPEPLDLDKMNRAAQQFIGTHDFTGFCSQKTEVESKVRTLYQSEIVKTDDGFDYIVTGSGFLYNMVRVLVAFLIEVGKGRHEVSDVPKLLESKNRKNVPFTAPAEGLYLEKIYLDENELLKDFGNDIKIHRKKSL
>NC_002952.2|WP_000791607.1|2389014_2389821_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MKNKLIIGRYLPINSFVHHLDPRAKLMFVFLFIILIFFCHSPLTYLWMFALILFFMRLAKIQLWFLIKGLTPIFFFLIFTLMMHIFLTKGGYVLVEWHGITIETNGILEGLYISLRLIGIVMIATIMTLSTSPIDLTDAFERLLAPLKMFKLPVHQLSMIMSIALRFIPTLMDELDKIILAQKSRGSEISSGNIATRIKSFIPLLVPLFISAFQRAEELAVAMEVRGYDANVKRTSYRQLKWQLRDTLSLIMIIPIAIILFVLKYSGV
>NC_002952.2|WP_000586768.1|2389810_2390671_-|energy-coupling-factor-transporter-ATPase
MIIRFDNVSYTYQKGTPYQHQAIHDVNTEFEQGKYYAIVGQTGSGKSTLIQNINALLKPTTGTVTVDDITITHKTKDKYIRPVRKRIGMVFQFPESQLFEDTVEREMIFGPKNFKMNLDEAKNYAHRLLMDLGFSRDVMSQSPFQMSGGQMRKIAIVSILAMNPDIIVVDEPTAGLDPQSKRQVMRLLKSLQTDENKTIILISHDMNEVARYADEVIVMKEGSIVSQTSPKELFKDKEKLADWHIGLPEIVQLQYDFEQKHQTKLKDIALTEEAFVSLYKEWQHEK
>NC_002952.2|WP_000389651.1|2390667_2391477_-|energy-coupling-factor-transporter-ATPase
MEDKNSVIVFKNVSFQYQSDASFTLKDVSFNIPKGQWTSIVGHNGSGKSTIAKLMIGIEKVKSGEIFYNNQAITDDNFEKLRKDIGIVFQNPDNQFVGSIVKYDVAFGLENHAVPHDEMHRRVSEALEQVDMLERADYEPNALSGGQKQRVAIASVLALNPSVIILDEATSMLDPDARQNLLDLVRKVKSEHNITIISITHDLSEAMEADHVIVMNKGTVYKEGTATEIFDHAEELTTIGLDLPFPIKINQMLGHQTSFLTYEGLVDQL
>NC_002952.2|WP_094409958.1|2391852_2393420_+|IS3-like-element-ISSau2-family-transposase
MKTLKGALFMSIKPKVDIDVLLYMFQEYEKGVSFQYLIDTLQLDINVNTLYPKYKYYKTHGIETLLTQKQYNHYSKELKLKVVNEYLNSNQSTQDIAIKYNIRSSTQVKNWIKMYTVGKEIKNQSPKTGVYIMKARKTTFEERVTIVEYYLNHKQSYREVAEHFNISYGQIYQWVHKYQAHGKNGLVDGRGKGKPKSMMTPEEQKEAEIQALKAQNRLLEMENDVFKKVSSIGKRDDSKRKQITAYKTIEALKHQYPIQRLCRILGISRASYYKWVHYQSSELELENEQLKREIESIYHKYNGIYGYRRIYIYIRLKLGKQVNRKRIYRLMKELNLKAVIRQKRKPYRRSTPQITSENKLNRQFDIDTPNKVWLTDVTEFKIKEGSKIYLSAIYDLGAKRIVSYELGPSNNNQLVFKTFNQAIEKVENTKGILFHSDRGFQYTSKTFKHMLDECGMIQSMSRVSKCIDNGPMEGVWGTIKSEIFRGNKHFKFNSVEEATKTIHDFILFFNHERITLKMADSV
>NC_002952.2|WP_000542274.1|2393672_2394041_-|50S-ribosomal-protein-L17
MGYRKLGRTSDQRKAMLRDLATSLIISERIETTEARAKEVRSVVEKLITLGKKGDLASRRNAAKTLRNVEILNEDETTQTALQKLFGEIAERYTERQGGYTRILKQGPRRGDGAESVIIELV
>NC_002952.2|WP_000569649.1|2394057_2395002_-|DNA-directed-RNA-polymerase-subunit-alpha
MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED

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Crispr_ID: NC_002952_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002952_8

2425157-2425237

Orphan

Consensus_repeat	Method
TCTATGTTGGGGCCCCGCCAACTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_002952_8

>merge|NC_002952|8|2425157-2425237|CRISPRCasFinder
TCTATGTTGGGGCCCCGCCAACTTGCACATTATTGTAAGCTGACTTTTCGTCACCTTCTATGTTGGGGCCCCGCCAATTTG

>NC_002952|8|6|2425157-2425237|CRISPRCasFinder
TCTATGTTGGGGCCCCGCCAACTTG	CACATTATTGTAAGCTGACTTTTCGTCACCT
TCTATGTTGGGGCCCCGCCAATTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_002952.2\|WP_000134529.1\|2429531_2430026_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
NC_002952.2\|WP_000808500.1\|2427267_2427714_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|223391
NC_002952.2\|WP_001573526.1\|2421537_2421789_+\|hypothetical-protein	unknown	unknown	unknown
NC_002952.2\|WP_000230171.1\|2425380_2426403_-\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|274250
NC_002952.2\|WP_000643988.1\|2426422_2427022_-\|molybdenum-cofactor-guanylyltransferase-MobA	unknown	unknown	gnl\|CDD\|234725
NC_002952.2\|WP_000076914.1\|2430562_2431567_-\|ThiF-family-adenylyltransferase	unknown	unknown	gnl\|CDD\|181084
NC_002952.2\|WP_000951069.1\|2422707_2423148_+\|winged-helix-DNA-binding-protein	unknown	unknown	gnl\|CDD\|197670
NC_002952.2\|WP_000184409.1\|2423140_2424352_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NC_002952.2\|WP_000592290.1\|2416599_2419767_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NC_002952.2\|WP_000913006.1\|2431734_2432340_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226628
NC_002952.2\|WP_000602938.1\|2427727_2428213_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	unknown	unknown	gnl\|CDD\|224677
NC_002952.2\|WP_001791501.1\|2424929_2425100_+\|hypothetical-protein	unknown	unknown	unknown
NC_002952.2\|WP_000413875.1\|2419883_2421149_-\|lipid-II:glycine-glycyltransferase-FemX	unknown	unknown	gnl\|CDD\|225224
NC_002952.2\|WP_001161085.1\|2416095_2416413_+\|hypothetical-protein	unknown	unknown	unknown
NC_002952.2\|WP_000503824.1\|2430027_2430534_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	unknown	unknown	gnl\|CDD\|223595
NC_002952.2\|WP_000051210.1\|2415686_2415851_+\|hypothetical-protein	unknown	unknown	unknown
NC_002952.2\|WP_000600967.1\|2421780_2422545_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|379203
NC_002952.2\|WP_000866973.1\|2427028_2427262_-\|molybdopterin-converting-factor-subunit-1	unknown	unknown	gnl\|CDD\|340452
NC_002952.2\|WP_000066900.1\|2424453_2424804_-\|HTH-type-transcriptional-regulator-SarV	unknown	unknown	gnl\|CDD\|130944
NC_002952.2\|WP_000259736.1\|2428209_2429469_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452

Protein	Function_ID	Function_description	E-value
NC_002952.2\|WP_000134529.1\|2429531_2430026_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	5.35275e-97
NC_002952.2\|WP_000600967.1\|2421780_2422545_-\|VOC-family-protein	gnl\|CDD\|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	1.50083e-38
NC_002952.2\|WP_000230171.1\|2425380_2426403_-\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|274250	TIGR02666, Cyclic_pyranopterin_monophosphate_synthase, molybdenum cofactor biosynthesis protein A, bacterial. The model for this family describes molybdenum cofactor biosynthesis protein A, or MoaA, as found in bacteria. It does not include the family of probable functional equivalent proteins from the archaea. MoaA works together with MoaC to synthesize precursor Z from guanine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin].	1.0538e-165
NC_002952.2\|WP_000951069.1\|2422707_2423148_+\|winged-helix-DNA-binding-protein	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.58234e-15
NC_002952.2\|WP_000076914.1\|2430562_2431567_-\|ThiF-family-adenylyltransferase	gnl\|CDD\|181084	PRK07688, PRK07688, thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated.	4.64376e-130
NC_002952.2\|WP_000643988.1\|2426422_2427022_-\|molybdenum-cofactor-guanylyltransferase-MobA	gnl\|CDD\|234725	PRK00317, mobA, molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed.	5.68918e-67
NC_002952.2\|WP_000592290.1\|2416599_2419767_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NC_002952.2\|WP_000913006.1\|2431734_2432340_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226628	COG4148, ModC, ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism].	1.03488e-114
NC_002952.2\|WP_000602938.1\|2427727_2428213_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	gnl\|CDD\|224677	COG1763, MobB, Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism].	3.19119e-50
NC_002952.2\|WP_000184409.1\|2423140_2424352_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.47845e-73
NC_002952.2\|WP_000413875.1\|2419883_2421149_-\|lipid-II:glycine-glycyltransferase-FemX	gnl\|CDD\|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	2.47464e-141
NC_002952.2\|WP_000503824.1\|2430027_2430534_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	gnl\|CDD\|223595	COG0521, MoaB, Molybdopterin biosynthesis enzymes [Coenzyme metabolism].	2.50849e-64
NC_002952.2\|WP_000808500.1\|2427267_2427714_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|223391	COG0314, MoaE, Molybdopterin converting factor, large subunit [Coenzyme metabolism].	5.56799e-58
NC_002952.2\|WP_000866973.1\|2427028_2427262_-\|molybdopterin-converting-factor-subunit-1	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	2.40505e-24
NC_002952.2\|WP_000066900.1\|2424453_2424804_-\|HTH-type-transcriptional-regulator-SarV	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	2.64009e-20
NC_002952.2\|WP_000259736.1\|2428209_2429469_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	7.37627e-158

>NC_002952.2|WP_001791501.1|2424929_2425100_+|hypothetical-protein
MFRFISFGQLVVYSTTFIPKKDILQLNDLECDNNVKEPLKIYYVVILKSGIEMIFS
>NC_002952.2|WP_000066900.1|2424453_2424804_-|HTH-type-transcriptional-regulator-SarV
MSNKVQRFIEAERELSQLKHWLKTTHKISIEEFVVLFKVYEAEKISGKELRDTLHFEMLWDTSKIDVIIRKIYKKELISKLRSETDERQVFYFYSTSQKKLLDKITKEIEVLSVTN
>NC_002952.2|WP_000184409.1|2423140_2424352_+|MFS-transporter
MTNQGSLNKSPIFTKSFTINFFVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLFIVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAVVTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILGILGVIISLFIKVDFEVTNSKTETNVIDKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILTYLQAFAIERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCLISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPSFLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
>NC_002952.2|WP_000951069.1|2422707_2423148_+|winged-helix-DNA-binding-protein
MLSQEFFNSFITIYRPYLKLTEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEKPTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNISQDQMQETINVMNQIHEILLKEAHND
>NC_002952.2|WP_000600967.1|2421780_2422545_-|VOC-family-protein
MILKFDHIIHYIDQLDRFSFPGDVIKLHSGGYHHKYGTFNKLGYINENYIELLDVENNEKLKKMAKTIEGGVAFATQIVQEKYEQGFKNICLRTNDIEAVKNKLQSEQVEVVGPIQMERDTHKDGKVKWQLLYIMNQDDDEIKPPFFIQWEESDSMRTKKLQKYFQKQFSIETVIVKSKNRSQTVSNWLKWFDMDIVEENDHYTDLILKNDDIYFRIEDGKVSKYHSVIIKDAQATSPYSIFIRGAIYRFEPLV
>NC_002952.2|WP_001573526.1|2421537_2421789_+|hypothetical-protein
MRTIILSLFIIMNIVAIIMTLSQPLTVNYFSLRVILIFFTFILSIFFILIKSSRLNNILTILSIALAIIHMGILAHSTYVYLY
>NC_002952.2|WP_000413875.1|2419883_2421149_-|lipid-II:glycine-glycyltransferase-FemX
MEKMHITNQEHDAFVKSNPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEIQGVAQLLFKKVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIAKVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLIEQVKPRLTKAKIKISRKLKRK
>NC_002952.2|WP_000592290.1|2416599_2419767_-|efflux-RND-transporter-permease-subunit
MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTSMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIKFKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIPLTLAGGQGQSQSQSDNKQNSAMSDVNQASPQQNSKTSASNNISGMPTAKLGDLADITVGDVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFVDENKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGVVSTTYKKVLHWSLNHKWIVIILSTLILVTTIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSSPVDPTGSTNSMAIMVEYDNDTPNFDVEADKVIKHADGFKHPGEWKNQDLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKIDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKRFTKR
>NC_002952.2|WP_001161085.1|2416095_2416413_+|hypothetical-protein
MQFYLILLAILYLIVSFISIFKMEVVFTRILRIIMGVLLLFVLALTTMSFPKENWWVFIVLLLLVGNVEVTGFKMLKKDLKGVNILNLMSLFIFVIYFILTIVLF
>NC_002952.2|WP_000051210.1|2415686_2415851_+|hypothetical-protein
MSLENQLAELKYDYVRLQGDLEKRESLNLDTSALVRQLKDIENEIRNVRAQMQD
>NC_002952.2|WP_000230171.1|2425380_2426403_-|GTP-3',8-cyclase-MoaA
MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATADGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
>NC_002952.2|WP_000643988.1|2426422_2427022_-|molybdenum-cofactor-guanylyltransferase-MobA
MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYPNVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIENHLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNVYHELSTDYLDVRDVDAPSYWYKNINYQHDLDALIQKL
>NC_002952.2|WP_000866973.1|2427028_2427262_-|molybdopterin-converting-factor-subunit-1
MKVLYFAEIKDILQKAQEDIVLEQALTVQQFENLLFERYPQINNKKFQVAVNEEFVQKSDFIQPNDTVALIPPVSGG
>NC_002952.2|WP_000808500.1|2427267_2427714_-|molybdenum-cofactor-biosynthesis-protein-MoaE
MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE
>NC_002952.2|WP_000602938.1|2427727_2428213_-|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B
MILQIVGYKKSGKTTLMRHIVSFLKSHGYTVATIKHHGHGKEDIQLQDSDVDHMKHFEAGADQSIVQGFQYQQTVTRVDNQNLTQIIEKSVTIDTNIVLVEGFKNADFEKVVVYRNEEELQVLQQLTNVCYSINVREHEDFTAFEQWLLNKIKNDCDTQLT
>NC_002952.2|WP_000259736.1|2428209_2429469_-|molybdopterin-molybdotransferase-MoeA
MVVEKRNPIPVKEAIQRIVNQQSTMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETTTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQQDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
>NC_002952.2|WP_000134529.1|2429531_2430026_+|cyclic-pyranopterin-monophosphate-synthase-MoaC
MTEFTHINQQGHAKMVDVSDKQITKRTAVAHSSITVNETIYKQISNNTNTKGNVLNTAQIAGIMAAKNTSTIIPMCHPLPLTGIDVHFNWDETNAPLYTLNIQTTVSTTGKTGVEMEALTAASATALTIYDMTKAVDKGMIIGETYLESKSGGKSGDFQRQLDQ
>NC_002952.2|WP_000503824.1|2430027_2430534_-|molybdenum-cofactor-biosynthesis-protein-MoaB
MGEHQNVKLNRTVKAAVLTVSDTRNFDTDKGGQCVLQLLQVDNVEVSDAHYTIVKDEKVAITTQVKKWLEEDVDVIITTGGTGIAQRDVTIEAVKPLLTKEIEGFGELFRYLSYVEDVGTRALLSRAVAGTVNDKLIFSIPGSTGAVKLALEKLIKPELNHLIHELTK
>NC_002952.2|WP_000076914.1|2430562_2431567_-|ThiF-family-adenylyltransferase
MSQERYSRQILFKQIGEIGQNKINQKCALIIGMGALGTHVAEGLVRAGIAKLIIVDRDYIEFSNLQRQTLFTEEDALKMMPKVVAAKKHLLALRSDVDIDDYIDHVDYYFLETHGQDVDVIIDATDNFETRQLINDFAYKHRIPWIYGGVVQSTYTEAAFIPGKTPCFNCLVPQLPALNLTCDTVGVIQPAVTMATSLQLRDAMKVLTEQPIDTKITYGDIWEGSHYSFGFSKMQRTACTTCGDVPSYPYLNKNEQRYATLCGRDTVQYENTSITHDILVQFLKQHQLNYRSNSYMVMFEFKGHRIVAFKGGRFLIHGMTRTSDATHLMNLLFG
>NC_002952.2|WP_000913006.1|2431734_2432340_-|ATP-binding-cassette-domain-containing-protein
MLKINLKYQLKNTLIRINIDDTEPKIYAVRGPSGIGKTTVLNMIAGLRKADEAIIEVNGQLLTDTAKNVNVKIQQRRIGYLFQDYQLFPNMTVYKNITFMAEPSEHIDQLIQTLNIDHLMKQYPMTLSGGEAQRVALARALSTKPDLILLDEPFSSLDDTTKDESITLVKRIFNEWQIPIIFVTHSNYEAEQMAHEIITIG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_002952_1	1.1\|848957\|33\|NC_002952\|CRISPRCasFinder	848957-848989	33	NC_002952.2	1082293-1082325	1	0.97
NC_002952_1	1.1\|848957\|33\|NC_002952\|CRISPRCasFinder	848957-848989	33	NC_002952.2	2459409-2459441	1	0.97
NC_002952_8	8.1\|2425182\|31\|NC_002952\|CRISPRCasFinder	2425182-2425212	31	NC_002952.2	1108571-1108601	1	0.968
NC_002952_8	8.1\|2425182\|31\|NC_002952\|CRISPRCasFinder	2425182-2425212	31	NC_002952.2	1729345-1729375	1	0.968
NC_002952_3	3.1\|956486\|26\|NC_002952\|CRISPRCasFinder	956486-956511	26	NC_002952.2	2198950-2198975	2	0.923
NC_002952_3	3.1\|956486\|26\|NC_002952\|CRISPRCasFinder	956486-956511	26	NC_002952.2	2259032-2259057	2	0.923
NC_002952_5	5.1\|2078922\|37\|NC_002952\|CRT	2078922-2078958	37	NC_002952.2	862223-862259	2	0.946
NC_002952_5	5.2\|2078980\|34\|NC_002952\|CRT	2078980-2079013	34	NC_002952.2	309331-309364	2	0.941
NC_002952_5	5.2\|2078980\|34\|NC_002952\|CRT	2078980-2079013	34	NC_002952.2	384088-384121	2	0.941
NC_002952_5	5.2\|2078980\|34\|NC_002952\|CRT	2078980-2079013	34	NC_002952.2	815792-815825	2	0.941
NC_002952_5	5.2\|2078980\|34\|NC_002952\|CRT	2078980-2079013	34	NC_002952.2	848996-849029	2	0.941
NC_002952_5	5.2\|2078980\|34\|NC_002952\|CRT	2078980-2079013	34	NC_002952.2	1108508-1108541	2	0.941
NC_002952_5	5.2\|2078980\|34\|NC_002952\|CRT	2078980-2079013	34	NC_002952.2	1855967-1856000	2	0.941
NC_002952_5	5.2\|2078980\|34\|NC_002952\|CRT	2078980-2079013	34	NC_002952.2	2425121-2425154	2	0.941
NC_002952_5	5.2\|2078980\|34\|NC_002952\|CRT	2078980-2079013	34	NC_002952.2	2567217-2567250	2	0.941
NC_002952_8	8.1\|2425182\|31\|NC_002952\|CRISPRCasFinder	2425182-2425212	31	NC_002952.2	862347-862377	2	0.935
NC_002952_8	8.1\|2425182\|31\|NC_002952\|CRISPRCasFinder	2425182-2425212	31	NC_002952.2	911617-911647	2	0.935
NC_002952_8	8.1\|2425182\|31\|NC_002952\|CRISPRCasFinder	2425182-2425212	31	NC_002952.2	956447-956477	2	0.935
NC_002952_8	8.1\|2425182\|31\|NC_002952\|CRISPRCasFinder	2425182-2425212	31	NC_002952.2	2068364-2068394	2	0.935

1. spacer 1.1|848957|33|NC_002952|CRISPRCasFinder matches to position: 1082293-1082325, mismatch: 1, identity: 0.97

attgggaatccaatttctctttgttggggccca	CRISPR spacer
attgggaatccaatttctctgtgttggggccca	Protospacer
******************** ************

2. spacer 1.1|848957|33|NC_002952|CRISPRCasFinder matches to position: 2459409-2459441, mismatch: 1, identity: 0.97

attgggaatccaatttctctttgttggggccca	CRISPR spacer
attgggaatccaatttctctttgttgggaccca	Protospacer
****************************.****

3. spacer 8.1|2425182|31|NC_002952|CRISPRCasFinder matches to position: 1108571-1108601, mismatch: 1, identity: 0.968

cacattattgtaagctgacttttcgtcacct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**************************** **

4. spacer 8.1|2425182|31|NC_002952|CRISPRCasFinder matches to position: 1729345-1729375, mismatch: 1, identity: 0.968

cacattattgtaagctgacttttcgtcacct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**************************** **

5. spacer 3.1|956486|26|NC_002952|CRISPRCasFinder matches to position: 2198950-2198975, mismatch: 2, identity: 0.923

cggggccccaacacagaagctggtgg	CRISPR spacer
cgcggccccaacacagaagctggcgg	Protospacer
** ********************.**

6. spacer 3.1|956486|26|NC_002952|CRISPRCasFinder matches to position: 2259032-2259057, mismatch: 2, identity: 0.923

cggggccccaacacagaagctggtgg	CRISPR spacer
cggggccccaacacaaaagctggcgg	Protospacer
***************.*******.**

7. spacer 5.1|2078922|37|NC_002952|CRT matches to position: 862223-862259, mismatch: 2, identity: 0.946

ccaacttgcacattattgtaagctgacagaaagtcag	CRISPR spacer
ccaacttgcacattattgtaagctggcggaaagtcag	Protospacer
*************************.*.*********

8. spacer 5.2|2078980|34|NC_002952|CRT matches to position: 309331-309364, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgcctgtagaatttcttttcgaaat	Protospacer
***********.************.*********

9. spacer 5.2|2078980|34|NC_002952|CRT matches to position: 384088-384121, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgtttgtagaatttcttttcgaaat	Protospacer
************.***********.*********

10. spacer 5.2|2078980|34|NC_002952|CRT matches to position: 815792-815825, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgtttgtagaatttcttttcgaaat	Protospacer
************.***********.*********

11. spacer 5.2|2078980|34|NC_002952|CRT matches to position: 848996-849029, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgcctgtagaatttcttttcgaaat	Protospacer
***********.************.*********

12. spacer 5.2|2078980|34|NC_002952|CRT matches to position: 1108508-1108541, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgcctgtagaatttcttttcgaaat	Protospacer
***********.************.*********

13. spacer 5.2|2078980|34|NC_002952|CRT matches to position: 1855967-1856000, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgtctgtagaatttctttttgaaat	Protospacer
************************.***.*****

14. spacer 5.2|2078980|34|NC_002952|CRT matches to position: 2425121-2425154, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgtctgtagaatttctttttgaaat	Protospacer
************************.***.*****

15. spacer 5.2|2078980|34|NC_002952|CRT matches to position: 2567217-2567250, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgtctgtagaatttctttttgaaat	Protospacer
************************.***.*****

16. spacer 8.1|2425182|31|NC_002952|CRISPRCasFinder matches to position: 862347-862377, mismatch: 2, identity: 0.935

cacattattgtaagctgacttttcgtcacct	CRISPR spacer
cacattattgtaagctgactttacgtcagct	Protospacer
********************** ***** **

17. spacer 8.1|2425182|31|NC_002952|CRISPRCasFinder matches to position: 911617-911647, mismatch: 2, identity: 0.935

cacattattgtaagctgacttttcgtcacct	CRISPR spacer
cacattattgtaagctggcttttcgtcagct	Protospacer
*****************.********** **

18. spacer 8.1|2425182|31|NC_002952|CRISPRCasFinder matches to position: 956447-956477, mismatch: 2, identity: 0.935

cacattattgtaagctgacttttcgtcacct	CRISPR spacer
cacattattgtaagctgacttttcgccagct	Protospacer
*************************.** **

19. spacer 8.1|2425182|31|NC_002952|CRISPRCasFinder matches to position: 2068364-2068394, mismatch: 2, identity: 0.935

cacattattgtaagctgacttttcgtcacct	CRISPR spacer
cacattatcgtaagctgacttttcgtcagct	Protospacer
********.******************* **

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

36402 : 90642

Streptococcus_phage(30.0%)

integrase,transposase

attL 37639:37654|attR 78591:78606

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001106057.1\|36402_37077_-\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	2.6e-127	99.1
WP_001817892.1\|37167_37365_-	protein rep	A0A286QS97	Streptococcus_phage	1.2e-08	62.0
WP_000336290.1\|37377_38151_-	protein rep	NA	NA	NA	NA
37639:37654	attL	NA	NA	NA	NA
WP_000119405.1\|38395_39658_-	plasmid recombination protein	NA	NA	NA	NA
WP_001242578.1\|40164_40569_-	bleomycin binding protein	NA	NA	NA	NA
WP_001795128.1\|40785_41556_-	aminoglycoside O-nucleotidyltransferase ANT(4')-Ia	NA	NA	NA	NA
WP_001106057.1\|41748_42423_-\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	2.6e-127	99.1
WP_000958858.1\|43604_44348_+	glycerophosphoryl diester phosphodiesterase	NA	NA	NA	NA
WP_000872606.1\|44444_44873_+	MaoC family dehydratase	NA	NA	NA	NA
WP_001801873.1\|44918_46928_-	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	NA	NA	NA	NA
WP_000952923.1\|47024_48782_+	beta-lactam sensor/signal transducer MecR1	NA	NA	NA	NA
WP_000369213.1\|48781_49126_+	mecA-type methicillin resistance repressor MecI	NA	NA	NA	NA
WP_014532405.1\|49237_49306_-	phenol-soluble modulin PSM-mec	NA	NA	NA	NA
WP_111764890.1\|49639_50770_+	ROK family transcriptional regulator	NA	NA	NA	NA
WP_000438836.1\|52250_53315_-	DsrE/DsrF/DrsH-like family protein	NA	NA	NA	NA
WP_000220507.1\|53450_53711_+	persulfide-sensing transcriptional repressor CstR	NA	NA	NA	NA
WP_000350222.1\|53710_54355_+	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_001092058.1\|54693_55356_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_001072201.1\|55889_56621_+	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	E4ZFQ0	Streptococcus_phage	1.9e-51	47.5
WP_000067268.1\|56746_57529_-	aminoglycoside nucleotidyltransferase ANT(9)-Ia	NA	NA	NA	NA
WP_000361059.1\|57679_58057_-\|transposase	transposase	NA	NA	NA	NA
WP_001557544.1\|58063_59956_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_000868132.1\|59952_61038_-\|integrase	tyrosine-type recombinase/integrase	A0A0A8WIF9	Clostridium_phage	4.5e-12	28.3
WP_000659050.1\|61156_61474_-	RadC family protein	NA	NA	NA	NA
WP_001092169.1\|61494_62001_-	DUF1643 domain-containing protein	NA	NA	NA	NA
WP_000700853.1\|62018_62330_-	hypothetical protein	NA	NA	NA	NA
WP_000859155.1\|62416_62767_-	hypothetical protein	NA	NA	NA	NA
WP_001186599.1\|63284_64913_-	recombinase family protein	A0A0S2SXR4	Bacillus_phage	4.2e-46	31.4
WP_000815654.1\|64934_66284_-	recombinase family protein	A0A2H4J388	uncultured_Caudovirales_phage	6.8e-18	25.2
WP_000195103.1\|66517_68311_-	DUF927 domain-containing protein	NA	NA	NA	NA
WP_000273824.1\|68310_68607_-	single-stranded DNA-binding protein	NA	NA	NA	NA
WP_001060127.1\|68799_69846_-	hypothetical protein	NA	NA	NA	NA
WP_000858967.1\|73396_74092_-	response regulator transcription factor	NA	NA	NA	NA
WP_000446429.1\|74066_76736_-	sensor histidine kinase KdpD	A0A2K9L0Z8	Tupanvirus	6.0e-10	21.5
WP_000631574.1\|76902_76983_+	K(+)-transporting ATPase subunit F	NA	NA	NA	NA
WP_000029430.1\|77003_78680_+	potassium-transporting ATPase subunit A	NA	NA	NA	NA
78591:78606	attR	NA	NA	NA	NA
WP_000852430.1\|78698_80720_+	K(+)-transporting ATPase subunit B	E4ZFI9	Streptococcus_phage	6.6e-41	29.0
WP_000626133.1\|81836_82706_-	hypothetical protein	NA	NA	NA	NA
WP_000411461.1\|82715_83612_-	DUF927 domain-containing protein	NA	NA	NA	NA
WP_001176969.1\|84730_85357_-	hypothetical protein	NA	NA	NA	NA
WP_001001347.1\|85471_86980_+	protein kinase	NA	NA	NA	NA
WP_000891228.1\|87144_89265_+	AAA family ATPase	NA	NA	NA	NA
WP_088356251.1\|89513_90642_+\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	6.4e-78	54.0

DBSCAN-SWA_2

407562 : 423491

Staphylococcus_phage(89.47%)

coat,integrase,terminase

attL 409098:409115|attR 424197:424214

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001052483.1\|407562_407754_-	hypothetical protein	U3PCX8	Staphylococcus_phage	4.9e-23	80.0
WP_001261460.1\|407997_408294_+	30S ribosomal protein S6	NA	NA	NA	NA
WP_000934799.1\|408314_408818_+	single-stranded DNA-binding protein	A0A1W6JPL9	Staphylococcus_phage	1.2e-60	74.7
WP_000897044.1\|408869_409112_+	30S ribosomal protein S18	NA	NA	NA	NA
409098:409115	attL	NA	NA	NA	NA
WP_001800370.1\|409343_410138_-	type II toxin-antitoxin system PemK/MazF family toxin	Q4ZE81	Staphylococcus_phage	5.6e-28	30.0
WP_000270135.1\|410175_411390_-\|integrase	site-specific integrase	Q4ZE80	Staphylococcus_phage	3.3e-221	97.3
WP_000230361.1\|411550_412174_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_001611932.1\|412322_412487_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_001138305.1\|412487_412760_+	winged helix-turn-helix domain-containing protein	Q4ZE77	Staphylococcus_phage	1.2e-43	94.4
WP_000784892.1\|412771_412945_+	hypothetical protein	NA	NA	NA	NA
WP_000403837.1\|413115_413499_+	hypothetical protein	A0A1W6JQI7	Staphylococcus_phage	4.8e-62	96.1
WP_001103967.1\|413499_413826_+	DUF1474 family protein	Q4ZE75	Staphylococcus_phage	3.5e-53	96.3
WP_001002709.1\|413890_414760_+	primase C-terminal domain-containing protein	Q4ZE74	Staphylococcus_phage	5.3e-165	96.2
WP_000447468.1\|414773_416483_+	DUF927 domain-containing protein	Q4ZE73	Staphylococcus_phage	8.2e-303	92.8
WP_000356942.1\|416792_417173_+	hypothetical protein	Q4ZE71	Staphylococcus_phage	1.7e-67	96.8
WP_001019762.1\|417169_417811_+	hypothetical protein	Q4ZE67	Staphylococcus_phage	4.7e-110	92.5
WP_001288442.1\|418518_418863_+	hypothetical protein	Q4ZE66	Staphylococcus_phage	1.3e-50	91.7
WP_000214170.1\|418893_419547_+	hypothetical protein	Q4ZE82	Staphylococcus_phage	7.6e-116	99.5
WP_000771361.1\|419599_420127_+\|coat	spore coat protein	Q4ZE87	Staphylococcus_phage	6.8e-91	100.0
WP_001656917.1\|420258_420471_+	hypothetical protein	Q4ZE86	Staphylococcus_phage	5.4e-31	97.1
WP_001293071.1\|420467_421037_+\|terminase	terminase small subunit	Q4ZE85	Staphylococcus_phage	4.6e-101	98.4
WP_000801980.1\|421313_422282_+	Abi family protein	A0A0H4U080	Erysipelothrix_phage	2.7e-24	27.3
WP_073392942.1\|422423_422861_+	DUF3102 domain-containing protein	A0A2H4JAH5	uncultured_Caudovirales_phage	9.8e-27	58.2
WP_000813311.1\|422978_423491_+	hypothetical protein	Q4ZE83	Staphylococcus_phage	1.4e-69	100.0
424197:424214	attR	NA	NA	NA	NA

DBSCAN-SWA_3

734447 : 764374

Staphylococcus_phage(41.67%)

bacteriocin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001105942.1\|734447_735122_+\|transposase	IS6-like element ISSau6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.3e-113	88.4
WP_001035802.1\|735156_735369_-	hypothetical protein	NA	NA	NA	NA
WP_000633163.1\|735688_736024_+	recombinase family protein	NA	NA	NA	NA
WP_000120605.1\|736084_736399_+	As(III)-sensing metalloregulatory transcriptional repressor ArsR	A0A2H4PQT4	Staphylococcus_phage	4.7e-39	73.1
WP_073392969.1\|736395_737688_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	2.5e-187	81.2
WP_000358995.1\|737705_738101_+	thioredoxin-dependent arsenate reductase	A0A2H4PQT9	Staphylococcus_phage	8.5e-62	86.3
WP_000726502.1\|738480_738774_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000713732.1\|738848_740783_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000831610.1\|740786_741098_+	YxeA family protein	NA	NA	NA	NA
WP_000593106.1\|741109_741736_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	6.1e-22	33.7
WP_000277743.1\|742097_743744_+\|transposase	IS1182-like element ISSau3 family transposase	A0ZS58	Staphylococcus_virus	6.1e-295	99.8
WP_001643491.1\|743898_744276_+	plasmid recombination protein	NA	NA	NA	NA
WP_001582045.1\|744215_744542_+	plasmid recombination protein	NA	NA	NA	NA
WP_000273007.1\|744608_745109_+	hypothetical protein	NA	NA	NA	NA
WP_000145511.1\|745473_746334_+	replication initiation protein	NA	NA	NA	NA
WP_000761344.1\|746420_746762_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_001002795.1\|746976_747072_-	type I toxin-antitoxin system Fst family toxin	NA	NA	NA	NA
WP_000998976.1\|749176_749602_+	hypothetical protein	NA	NA	NA	NA
WP_000713115.1\|750463_750637_+	hypothetical protein	NA	NA	NA	NA
WP_000397995.1\|750818_751142_-	hypothetical protein	NA	NA	NA	NA
WP_001791613.1\|751370_751463_+	type I toxin-antitoxin system Fst family toxin	NA	NA	NA	NA
WP_000377738.1\|751764_752586_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_000838599.1\|752710_753706_+	YeiH family protein	NA	NA	NA	NA
WP_000690626.1\|754040_754616_-	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	2.9e-42	51.7
WP_000069452.1\|754882_756928_+	copper-translocating P-type ATPase CopB	E4ZFI9	Streptococcus_phage	2.3e-65	29.2
WP_000277154.1\|756942_758376_+	multi-copper oxidase Mco	NA	NA	NA	NA
WP_000277738.1\|758442_760089_-\|transposase	IS1182 family transposase	A0ZS58	Staphylococcus_virus	1.0e-289	98.4
WP_000378396.1\|760451_762632_-	cadmium-translocating P-type ATPase CadA	E4ZFI9	Streptococcus_phage	9.3e-251	63.7
WP_000159128.1\|762624_762990_-	winged helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	8.5e-24	47.8
WP_000361064.1\|763227_763605_-	hypothetical protein	NA	NA	NA	NA
WP_001105942.1\|763699_764374_+\|transposase	IS6-like element ISSau6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.3e-113	88.4

DBSCAN-SWA_4

794173 : 801993

Hokovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244416.1\|794173_795229_-	two-component system sensor histidine kinase SaeS	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_000149344.1\|795228_795915_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037807.1\|795889_796363_-	DoxX family protein	NA	NA	NA	NA
WP_001093552.1\|796704_797145_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637686.1\|797424_798009_-	hypothetical protein	NA	NA	NA	NA
WP_001062968.1\|798107_798821_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941336.1\|798824_799244_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446724.1\|799245_799914_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000604508.1\|800264_800858_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	6.8e-39	44.0
WP_001217804.1\|800841_801993_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	2.1e-23	36.1

DBSCAN-SWA_5

813965 : 828103

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663016.1\|813965_815024_+	histidinol-phosphate transaminase	A0A0H3TLT9	Faustovirus	5.7e-20	26.5
WP_000197262.1\|815182_815725_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429002.1\|816276_817194_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	8.2e-07	22.0
WP_031788440.1\|817284_817386_+	hypothetical protein	NA	NA	NA	NA
WP_000193750.1\|817463_818969_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930016.1\|819308_819809_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	2.7e-52	66.2
WP_001068491.1\|819828_820695_-	DMT family transporter	NA	NA	NA	NA
WP_000692521.1\|821496_821895_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_000855505.1\|821857_823963_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|824082_825054_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000876311.1\|825430_826402_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	7.8e-141	80.2
WP_001245566.1\|826388_827345_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	5.5e-06	60.0
WP_000616865.1\|827341_828103_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	7.2e-17	30.1

DBSCAN-SWA_6

998072 : 1049825

Bacillus_virus(25.0%)

bacteriocin,tRNA,holin,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000121211.1\|998072_999020_-\|transposase	IS30-like element ISSau1 family transposase	Q9MBM9	Staphylococcus_prophage	1.1e-184	100.0
WP_001067041.1\|1000654_1001641_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.8e-15	30.0
WP_000427776.1\|1001643_1002624_+	dipeptide ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.7e-16	34.1
WP_001574526.1\|1002616_1003267_+	ABC transporter permease	NA	NA	NA	NA
WP_001180271.1\|1003278_1004160_+	ABC transporter permease	NA	NA	NA	NA
WP_001794171.1\|1006110_1007757_+\|transposase	IS1182 family transposase	A0ZS58	Staphylococcus_virus	1.7e-289	98.4
WP_000448933.1\|1007783_1008773_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_000258003.1\|1009067_1009463_+	transcriptional regulator Spx	NA	NA	NA	NA
WP_001217728.1\|1009833_1010553_+	adaptor protein MecA	NA	NA	NA	NA
WP_000959276.1\|1010673_1011660_+	competence protein CoiA	NA	NA	NA	NA
WP_000082722.1\|1011707_1013516_+	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	9.3e-47	24.5
WP_000896692.1\|1013975_1014782_-	DsbA family protein	NA	NA	NA	NA
WP_000214067.1\|1014804_1015170_-	truncated hemoglobin	NA	NA	NA	NA
WP_000224620.1\|1015273_1015867_-	CYTH domain-containing protein	NA	NA	NA	NA
WP_001242102.1\|1016052_1016400_+	hypothetical protein	NA	NA	NA	NA
WP_001077683.1\|1016416_1017052_+	GTP pyrophosphokinase family protein	NA	NA	NA	NA
WP_001270834.1\|1017068_1017878_+	NAD kinase	NA	NA	NA	NA
WP_000669938.1\|1017874_1018729_+	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_000062404.1\|1018749_1020135_+	magnesium transporter	NA	NA	NA	NA
WP_000395156.1\|1020144_1021989_+	monovalent cation:proton antiporter family protein	NA	NA	NA	NA
WP_000933195.1\|1022266_1023037_+	enoyl-ACP reductase FabI	NA	NA	NA	NA
WP_000933105.1\|1023232_1024318_-	AI-2E family transporter	NA	NA	NA	NA
WP_000570704.1\|1024659_1026228_+	alanine:cation symporter family protein	NA	NA	NA	NA
WP_000889176.1\|1026370_1027129_+	esterase family protein	NA	NA	NA	NA
WP_001060545.1\|1027294_1028020_+	hypothetical protein	NA	NA	NA	NA
WP_000355331.1\|1028021_1028873_+	hypothetical protein	NA	NA	NA	NA
WP_000600387.1\|1029614_1030124_+	2'-5' RNA ligase family protein	NA	NA	NA	NA
WP_001154224.1\|1030236_1031427_-	MFS transporter	NA	NA	NA	NA
WP_000258651.1\|1031404_1032580_-	diglucosyl diacylglycerol synthase	NA	NA	NA	NA
WP_000340133.1\|1033011_1034496_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
WP_001794242.1\|1034476_1034737_+	YueH family protein	NA	NA	NA	NA
WP_001049957.1\|1034736_1036299_+	peptide chain release factor 3	A0A1S5SF82	Streptococcus_phage	2.2e-36	28.2
WP_000928413.1\|1036600_1037404_+	TerC family protein	S5MAL1	Bacillus_phage	1.6e-30	40.5
WP_001794169.1\|1037622_1039947_+	trypsin-like peptidase domain-containing protein	W5SAB9	Pithovirus	4.0e-10	26.8
WP_000021872.1\|1039963_1041322_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000414169.1\|1041460_1042972_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_000287265.1\|1043460_1044030_-	competence protein ComK	NA	NA	NA	NA
WP_000876825.1\|1044239_1044458_+	IDEAL domain-containing protein	NA	NA	NA	NA
WP_000668820.1\|1044538_1045525_-	lipoate--protein ligase	NA	NA	NA	NA
WP_000214898.1\|1045723_1045900_+	YkvS family protein	NA	NA	NA	NA
WP_001033867.1\|1045914_1046517_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_099119695.1\|1046817_1046895_+\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_001790623.1\|1047433_1047535_+	hypothetical protein	NA	NA	NA	NA
WP_001794574.1\|1047544_1047817_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000870819.1\|1047860_1049825_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA

DBSCAN-SWA_7

1083821 : 1092294

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000861576.1\|1083821_1084304_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	8.0e-22	44.7
WP_001010391.1\|1084290_1085415_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174051.1\|1085418_1086123_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.3e-48	41.6
WP_000848351.1\|1086122_1086386_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666808.1\|1086387_1087059_+	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000032734.1\|1087051_1089241_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.1e-140	39.2
WP_000483716.1\|1089219_1090704_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.5e-46	31.4
WP_000030814.1\|1090696_1091725_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	7.6e-62	41.4
WP_000238673.1\|1091727_1092294_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.6e-29	40.1

DBSCAN-SWA_8

1556832 : 1637413

103

Staphylococcus_phage(76.92%)

tRNA,portal,tail,terminase,head,holin,capsid,protease,integrase,plate

attL 1591597:1591625|attR 1637497:1637525

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000858795.1\|1556832_1558125_-\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	4.3e-54	30.0
WP_000525060.1\|1558446_1561140_-	ATP-dependent helicase DinG	A0A1X9I5C8	Streptococcus_phage	8.2e-47	34.4
WP_000049917.1\|1561163_1562135_-	biotin--[acetyl-CoA-carboxylase] ligase	NA	NA	NA	NA
WP_000361536.1\|1562121_1563324_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	1.4e-35	42.5
WP_000690024.1\|1563328_1564471_-	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA	NA	NA	NA	NA
WP_000839927.1\|1564714_1565032_-	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_001827022.1\|1565367_1566048_-	zinc metallopeptidase	NA	NA	NA	NA
WP_000154479.1\|1566119_1566707_-	DUF1405 domain-containing protein	NA	NA	NA	NA
WP_000005208.1\|1566696_1567272_-	YpiB family protein	G3MAV7	Bacillus_virus	4.6e-08	27.2
WP_000389521.1\|1567285_1568530_-	hypothetical protein	NA	NA	NA	NA
WP_000245891.1\|1568536_1569835_-	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_000776318.1\|1569844_1570909_-	3-dehydroquinate synthase	NA	NA	NA	NA
WP_001269937.1\|1570934_1572101_-	chorismate synthase	A0A291AU41	Pandoravirus	1.5e-34	32.3
WP_000442480.1\|1572569_1573019_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	2.4e-28	43.8
WP_001096481.1\|1573110_1574070_-	polyprenyl synthetase family protein	A0A1V0SE37	Indivirus	1.3e-10	24.4
WP_000774679.1\|1574071_1574797_-	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_000450555.1\|1574799_1575372_-	heptaprenyl diphosphate synthase component 1	NA	NA	NA	NA
WP_001043863.1\|1575802_1576075_-	HU family DNA-binding protein	A7KV42	Bacillus_phage	4.2e-28	73.3
WP_000161753.1\|1576245_1577244_-	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_000165530.1\|1577260_1578571_-	ribosome biogenesis GTPase Der	NA	NA	NA	NA
WP_000133953.1\|1578792_1579968_-	30S ribosomal protein S1	NA	NA	NA	NA
WP_001791199.1\|1580224_1580416_-	hypothetical protein	NA	NA	NA	NA
WP_001791200.1\|1580532_1580649_-	hypothetical protein	NA	NA	NA	NA
WP_000644393.1\|1580679_1581339_-	(d)CMP kinase	NA	NA	NA	NA
WP_000681744.1\|1581415_1582384_+	asparaginase	NA	NA	NA	NA
WP_001174260.1\|1582498_1583485_-	YpdA family putative bacillithiol disulfide reductase	NA	NA	NA	NA
WP_016186859.1\|1583645_1583732_-	hypothetical protein	NA	NA	NA	NA
WP_000069298.1\|1583869_1585330_-	elastin-binding protein EbpS	NA	NA	NA	NA
WP_000902107.1\|1585482_1586862_-	ATP-dependent DNA helicase RecQ	L7RCS0	Acanthamoeba_polyphaga_moumouvirus	2.9e-56	33.3
WP_001163814.1\|1586851_1587805_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_001151997.1\|1587912_1588161_+	ferredoxin	A0A127AYY7	Bacillus_phage	8.3e-15	48.0
WP_001186908.1\|1588266_1588812_-	ECF transporter S component	NA	NA	NA	NA
WP_001799520.1\|1589090_1589255_-	hypothetical protein	NA	NA	NA	NA
WP_000476878.1\|1589459_1590368_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000913238.1\|1590425_1591331_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000126130.1\|1591420_1591636_-	hypothetical protein	A0ZS61	Staphylococcus_virus	2.0e-25	100.0
1591597:1591625	attL	NA	NA	NA	NA
WP_000930261.1\|1592357_1593812_-	N-acetylmuramoyl-L-alanine amidase	A0A0N6WMR3	Staphylococcus_phage	2.0e-289	99.8
WP_000339142.1\|1593823_1594126_-\|holin	phage holin	A0A2I6PF56	Staphylococcus_phage	1.2e-47	99.0
WP_000466784.1\|1594261_1594561_-	DUF2951 domain-containing protein	A0A2I6PER2	Staphylococcus_phage	2.0e-31	100.0
WP_000916020.1\|1594606_1594771_-	XkdX family protein	A0A2I6PES4	Staphylococcus_phage	4.9e-24	100.0
WP_001166599.1\|1594763_1595153_-	DUF2977 domain-containing protein	A0A2I6PER1	Staphylococcus_phage	2.2e-62	100.0
WP_000067145.1\|1595152_1596619_-\|plate	BppU family phage baseplate upper protein	A7TWK6	Staphylococcus_phage	6.0e-254	99.0
WP_000429551.1\|1596618_1598529_-	minor structural protein	A0A2I6PF35	Staphylococcus_phage	0.0e+00	100.0
WP_000179864.1\|1598544_1598835_-	hypothetical protein	R4WEC3	Staphylococcus_phage	2.1e-49	100.0
WP_000384474.1\|1598834_1600418_-\|tail	phage tail protein	A0A2I6PEQ5	Staphylococcus_phage	9.3e-309	100.0
WP_001190533.1\|1600426_1601251_-\|tail	phage tail family protein	A0A2I6PER3	Staphylococcus_phage	4.1e-159	100.0
WP_001003436.1\|1601250_1607451_-\|tail	phage tail tape measure protein	U5U762	Staphylococcus_phage	0.0e+00	98.6
WP_000438833.1\|1607464_1607623_-	hypothetical protein	A0A2I6PES8	Staphylococcus_phage	1.2e-19	100.0
WP_000589167.1\|1607664_1608015_-	hypothetical protein	A0A2I6PEQ2	Staphylococcus_phage	1.1e-55	100.0
WP_000169127.1\|1608072_1608528_-	Ig domain-containing protein	A0A2I6PER6	Staphylococcus_phage	5.7e-78	100.0
WP_000807536.1\|1608619_1609261_-\|tail	tail protein	A0A2I6PEP6	Staphylococcus_phage	5.9e-121	100.0
WP_001023806.1\|1609295_1609691_-	DUF3168 domain-containing protein	A0A2I6PEQ4	Staphylococcus_phage	8.8e-67	100.0
WP_000110023.1\|1609691_1610093_-	hypothetical protein	A0A2I6PF54	Staphylococcus_phage	8.1e-68	100.0
WP_000395502.1\|1610089_1610422_-	hypothetical protein	A0A2I6PEA5	Staphylococcus_phage	3.1e-57	100.0
WP_000050973.1\|1610433_1610712_-\|head,tail	phage gp6-like head-tail connector protein	A0A2I6PEQ1	Staphylococcus_phage	2.1e-46	100.0
WP_001142734.1\|1610780_1611944_-\|capsid	phage major capsid protein	A0A2I6PEQ3	Staphylococcus_phage	1.2e-217	100.0
WP_000061871.1\|1611955_1612729_-\|protease	Clp protease ClpP	A0A2I6PEQ7	Staphylococcus_phage	7.1e-137	99.6
WP_001100670.1\|1612712_1613951_-\|portal	phage portal protein	A0A2I6PEA6	Staphylococcus_phage	6.9e-235	100.0
WP_000153547.1\|1613955_1615647_-\|terminase	terminase large subunit	A0A2I6PDP8	Staphylococcus_phage	0.0e+00	99.6
WP_000778932.1\|1615636_1615942_-\|terminase	P27 family phage terminase small subunit	A0A2I6PE27	Staphylococcus_phage	2.9e-49	100.0
WP_000160688.1\|1616067_1616382_-	HNH endonuclease	A0A2I6PDR3	Staphylococcus_phage	1.6e-50	89.4
WP_000528514.1\|1616538_1616976_-	transcriptional regulator	B5WZN8	Staphylococcus_phage	2.7e-77	100.0
WP_001793488.1\|1616988_1618356_-	DEAD/DEAH box helicase	A0A2I6PE95	Staphylococcus_phage	1.7e-263	100.0
WP_000665205.1\|1618336_1618627_-	VRR-NUC domain-containing protein	U5U7A3	Staphylococcus_phage	4.9e-51	100.0
WP_015978074.1\|1618760_1618865_+	hypothetical protein	A0A2I6PDP6	Staphylococcus_phage	2.7e-12	100.0
WP_000884880.1\|1618967_1621415_-	virulence-associated E family protein	M1RZC5	Staphylococcus_phage	0.0e+00	99.1
WP_000265258.1\|1621467_1621668_-	DUF1514 family protein	A0A2I6PF41	Staphylococcus_phage	2.9e-26	100.0
WP_000595237.1\|1621735_1621888_-	transcriptional activator RinB	B5WZN3	Staphylococcus_phage	2.6e-19	100.0
WP_000483477.1\|1621880_1622117_-	hypothetical protein	A7TWB3	Staphylococcus_phage	1.9e-37	100.0
WP_000195761.1\|1622141_1622378_-	DUF1381 domain-containing protein	M1T303	Staphylococcus_phage	9.6e-37	100.0
WP_001209216.1\|1622394_1622568_-	hypothetical protein	A0A1W6JQ45	Staphylococcus_phage	4.7e-25	100.0
WP_000185684.1\|1622604_1623141_-	dUTP diphosphatase	S4V978	Staphylococcus_phage	2.7e-95	98.9
WP_001065239.1\|1623133_1623382_-	DUF1024 family protein	Q9B0F3	Staphylococcus_virus	5.9e-37	96.3
WP_000615884.1\|1623374_1623806_-	hypothetical protein	Q4ZBT4	Staphylococcus_virus	1.6e-74	99.3
WP_000983947.1\|1623805_1623997_-	hypothetical protein	Q4ZBT5	Staphylococcus_virus	1.5e-27	100.0
WP_001062709.1\|1623993_1624386_-	hypothetical protein	A0A2I6PE39	Staphylococcus_phage	1.6e-68	100.0
WP_000132195.1\|1624400_1624643_-	hypothetical protein	Q4ZBT7	Staphylococcus_virus	7.5e-37	93.8
WP_000235324.1\|1624657_1624858_-	hypothetical protein	A0A2I6PEM3	Staphylococcus_phage	2.5e-30	100.0
WP_000022728.1\|1624860_1625118_-	DUF3310 domain-containing protein	A0A2I6PEN5	Staphylococcus_phage	2.6e-43	100.0
WP_000113974.1\|1625117_1625519_-	PVL family protein	A0A2I6PEL5	Staphylococcus_phage	1.2e-68	100.0
WP_001164629.1\|1625518_1625704_-	DUF3113 family protein	A0A2I6PEM8	Staphylococcus_phage	7.0e-27	100.0
WP_001819907.1\|1625716_1627669_-	DNA polymerase	A0A2I6PE86	Staphylococcus_phage	0.0e+00	99.7
WP_000645048.1\|1627736_1628294_-	DUF2815 family protein	A0A2I6PEP8	Staphylococcus_phage	1.8e-97	100.0
WP_000762529.1\|1628319_1629486_-	DUF2800 domain-containing protein	B5WZM3	Staphylococcus_phage	3.1e-221	99.7
WP_000985973.1\|1629482_1629845_-	hypothetical protein	B5WZM2	Staphylococcus_phage	3.2e-55	99.2
WP_000174999.1\|1629859_1630183_-	hypothetical protein	A0A2I6PE70	Staphylococcus_phage	3.2e-51	99.1
WP_001285948.1\|1630261_1630423_-	DUF1270 domain-containing protein	A9CR58	Staphylococcus_phage	1.1e-20	98.1
WP_001124193.1\|1630435_1630699_-	helix-turn-helix domain-containing protein	M1SVD9	Staphylococcus_phage	9.7e-46	98.9
WP_001097552.1\|1630725_1630941_-	hypothetical protein	A0A2I6PF01	Staphylococcus_phage	1.9e-31	100.0
WP_001128433.1\|1630995_1631361_+	hypothetical protein	A0A2I6PF07	Staphylococcus_phage	2.4e-63	100.0
WP_001025401.1\|1631329_1631575_-	DUF2829 domain-containing protein	A0A2I6PF15	Staphylococcus_phage	5.1e-41	100.0
WP_000773059.1\|1631641_1632022_+	DUF2513 domain-containing protein	Q4ZCQ5	Staphylococcus_virus	5.8e-68	100.0
WP_001148860.1\|1632008_1632206_-	hypothetical protein	A7TWF5	Staphylococcus_phage	4.6e-24	100.0
WP_000362644.1\|1632275_1632488_+	hypothetical protein	D2JGJ1	Staphylococcus_phage	7.6e-33	100.0
WP_000771849.1\|1632528_1632678_-	hypothetical protein	D2JGJ0	Staphylococcus_phage	1.4e-20	100.0
WP_000435362.1\|1632692_1633136_-	hypothetical protein	A7TWF2	Staphylococcus_phage	3.4e-75	99.3
WP_000333485.1\|1633153_1633378_-	DUF739 family protein	A0A2I6PE94	Staphylococcus_phage	2.7e-36	100.0
WP_001089477.1\|1633539_1633920_+	helix-turn-helix domain-containing protein	A0A2I6PE55	Staphylococcus_phage	1.5e-63	99.2
WP_000521395.1\|1633941_1634400_+	hypothetical protein	B2ZYU2	Staphylococcus_phage	1.2e-83	100.0
WP_000755719.1\|1634417_1634852_+	hypothetical protein	A0A2D1G561	Staphylococcus_phage	2.8e-26	100.0
WP_000449656.1\|1634880_1635276_+	hypothetical protein	A0ZS06	Staphylococcus_virus	1.7e-70	100.0
WP_001166482.1\|1635474_1636098_-	hypothetical protein	B7T0F3	Staphylococcus_virus	9.8e-105	99.5
WP_000264191.1\|1636207_1637413_+\|integrase	site-specific integrase	M1RZA8	Staphylococcus_phage	1.0e-222	100.0
1637497:1637525	attR	NA	NA	NA	NA

DBSCAN-SWA_9

1700965 : 1709277

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001213908.1\|1700965_1701751_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
WP_000924211.1\|1701876_1702767_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
WP_001062173.1\|1702776_1704123_-	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	1.4e-55	34.0
WP_000683921.1\|1704236_1705337_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	3.0e-08	30.6
WP_000624581.1\|1705339_1706017_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_001283055.1\|1706147_1707254_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_001217253.1\|1707477_1709277_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.5e-54	36.0

DBSCAN-SWA_10

1778712 : 1787755

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1778712_1779231_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_000595001.1\|1779252_1781526_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	6.2e-64	29.3
WP_000749802.1\|1781728_1784008_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1784282_1784543_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1784561_1785701_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001019178.1\|1785723_1786749_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005767.1\|1786750_1787755_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_11

1924194 : 1971600

Staphylococcus_phage(94.44%)

protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001050520.1\|1924194_1930764_-	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	1.7e-295	88.7
WP_000836472.1\|1931087_1931399_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	4.5e-50	96.1
WP_001573995.1\|1931420_1933838_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	98.8
WP_001025064.1\|1934126_1935308_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	9.6e-218	99.7
WP_000526541.1\|1935418_1936372_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	6.4e-79	99.3
WP_000764425.1\|1936368_1936932_+	class I SAM-dependent methyltransferase	A0A2H4PQV0	Staphylococcus_phage	1.1e-99	95.7
WP_000757543.1\|1937050_1937452_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266099.1\|1938024_1938852_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_014937042.1\|1938854_1938974_-	hypothetical protein	NA	NA	NA	NA
WP_001196351.1\|1939085_1940087_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	5.0e-183	99.1
WP_001008556.1\|1940208_1940673_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.9e-68	97.4
WP_001159032.1\|1940685_1941867_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	6.6e-227	99.7
WP_000493891.1\|1941877_1942510_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	8.4e-112	99.0
WP_000077342.1\|1942516_1943560_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	5.9e-195	98.3
WP_001261683.1\|1944040_1945543_-	FAD/NAD(P)-binding protein	A0A2H4PQX2	Staphylococcus_phage	5.0e-30	98.6
WP_000221181.1\|1946185_1946500_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	1.7e-52	97.1
WP_000989104.1\|1946499_1947792_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	2.6e-216	95.1
WP_001032833.1\|1947878_1948733_-	glucosaminidase domain-containing protein	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1949008_1949233_-	hypothetical protein	NA	NA	NA	NA
WP_000671059.1\|1949431_1949902_+	RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	7.7e-70	85.8
WP_001152695.1\|1950014_1950458_+	competence protein ComK	NA	NA	NA	NA
WP_001030476.1\|1950444_1950888_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	2.4e-49	77.4
WP_001168914.1\|1951185_1951821_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000492901.1\|1951987_1952608_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001096494.1\|1953065_1953779_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091444.1\|1954037_1954340_+	hypothetical protein	NA	NA	NA	NA
WP_001200542.1\|1954594_1954960_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-59	100.0
WP_000623481.1\|1954956_1955310_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	4.2e-20	97.4
WP_000453309.1\|1955559_1956393_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	2.7e-158	99.3
WP_000366165.1\|1956604_1957513_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	9.8e-138	99.7
WP_000933819.1\|1957637_1958831_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	4.3e-218	99.5
WP_000109909.1\|1959202_1960795_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	99.8
WP_001801476.1\|1961087_1961834_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	3.3e-139	97.2
WP_000672010.1\|1961838_1962312_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	9.5e-84	98.1
WP_000718107.1\|1962377_1962635_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778539.1\|1962631_1963633_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	8.5e-183	96.7
WP_000348372.1\|1963637_1965116_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.4e-282	97.2
WP_016186903.1\|1965274_1965730_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	3.5e-75	94.5
WP_001794016.1\|1966031_1966682_+	excalibur calcium-binding domain-containing protein	A0A2H4PQM8	Staphylococcus_phage	1.0e-51	88.4
WP_000070654.1\|1966762_1967758_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	3.8e-74	97.2
WP_000669038.1\|1967833_1968460_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	4.5e-81	84.1
WP_000627550.1\|1968500_1968845_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	5.1e-55	94.7
WP_000414222.1\|1968942_1969515_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	3.2e-25	94.8
WP_001093574.1\|1969663_1971031_-	FRG domain-containing protein	NA	NA	NA	NA
WP_000125075.1\|1971030_1971600_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	2.2e-39	54.8

DBSCAN-SWA_12

2079581 : 2179886

119

Staphylococcus_phage(87.65%)

tRNA,portal,tail,terminase,holin,head,capsid,protease,integrase,transposase

attL 2078909:2078928|attR 2173540:2173559

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2078909:2078928	attL	NA	NA	NA	NA
WP_000545373.1\|2079581_2081009_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_000027924.1\|2081021_2082479_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_000170162.1\|2082480_2082783_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_000957023.1\|2083149_2084688_+	sodium/proline symporter PutP	NA	NA	NA	NA
WP_000831691.1\|2084776_2085976_-	CamS family sex pheromone protein	NA	NA	NA	NA
WP_000774552.1\|2085988_2087992_-	NAD-dependent DNA ligase LigA	A0A0K2QQN8	Ralstonia_phage	9.8e-114	36.1
WP_000992926.1\|2087995_2090188_-	DNA helicase PcrA	A7KV33	Bacillus_phage	2.9e-135	42.1
WP_000272063.1\|2090184_2090877_-	heptaprenylglyceryl phosphate synthase	NA	NA	NA	NA
WP_001165363.1\|2091059_2091362_-	hypothetical protein	NA	NA	NA	NA
WP_000572878.1\|2091470_2092766_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.6e-16	32.9
WP_000827736.1\|2093616_2094783_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
WP_000434532.1\|2094813_2095137_+	staphostatin A	NA	NA	NA	NA
WP_000669861.1\|2095430_2095604_-	NETI motif-containing protein	NA	NA	NA	NA
WP_000011542.1\|2095584_2096187_-	DUF2179 domain-containing protein	NA	NA	NA	NA
WP_000040861.1\|2096456_2097278_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	2.3e-69	52.7
WP_000284438.1\|2097270_2098740_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	1.9e-106	44.5
WP_000897633.1\|2098923_2100000_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
WP_001177832.1\|2100019_2100814_+	prephenate dehydratase	NA	NA	NA	NA
WP_031788442.1\|2100885_2100993_+	hypothetical protein	NA	NA	NA	NA
WP_000323171.1\|2101003_2102566_-	SLC13 family permease	NA	NA	NA	NA
WP_000275719.1\|2102770_2103868_-	pectate lyase	U5PWM6	Bacillus_phage	8.7e-48	34.6
WP_000149686.1\|2104240_2104801_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
WP_001140871.1\|2104853_2105783_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
WP_001790680.1\|2105974_2106148_-	hypothetical protein	NA	NA	NA	NA
WP_001021224.1\|2106199_2107579_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_000181322.1\|2107698_2108727_-	lactonase family protein	NA	NA	NA	NA
WP_000205106.1\|2108997_2109399_+	YolD-like family protein	U3PG23	Staphylococcus_phage	6.0e-23	42.9
WP_000267034.1\|2109455_2109629_-	hypothetical protein	NA	NA	NA	NA
WP_001188074.1\|2110079_2111120_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_000713064.1\|2111176_2112019_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_001033968.1\|2112015_2112573_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000966288.1\|2112632_2113157_-	membrane protein	NA	NA	NA	NA
WP_000182842.1\|2113277_2113841_+	thioredoxin family protein	NA	NA	NA	NA
WP_001221650.1\|2113904_2114645_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
WP_000763048.1\|2114644_2115517_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	6.1e-28	35.2
WP_000645732.1\|2115513_2116194_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
WP_000991315.1\|2116194_2117091_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	1.1e-16	30.2
WP_000691584.1\|2117087_2117468_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000681966.1\|2117725_2117902_-	hypothetical protein	NA	NA	NA	NA
WP_000990056.1\|2118143_2118242_-	hypothetical protein	NA	NA	NA	NA
WP_001068528.1\|2118441_2119728_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_000277709.1\|2119975_2121622_-\|transposase	IS1182-like element ISSau3 family transposase	A0ZS58	Staphylococcus_virus	7.9e-295	99.8
WP_000669729.1\|2121919_2123989_-	MAP domain-containing protein	NA	NA	NA	NA
WP_000669789.1\|2124946_2125126_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	2.2e-25	100.0
WP_001791826.1\|2125436_2125697_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_000702263.1\|2125749_2126100_-	complement inhibitor SCIN-A	A0A1P8L6B0	Staphylococcus_phage	7.5e-54	100.0
WP_000727649.1\|2126785_2127235_+	chemotaxis-inhibiting protein CHIPS	A0A1P8L6A8	Staphylococcus_phage	1.1e-78	100.0
WP_000919350.1\|2128314_2128806_-	staphylokinase	A0A1X9H028	Staphylococcus_phage	9.5e-87	100.0
WP_000861038.1\|2128997_2129753_-	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	3.4e-152	100.0
WP_000611512.1\|2129764_2130019_-\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
WP_001791821.1\|2130070_2130178_+	hypothetical protein	NA	NA	NA	NA
WP_011447039.1\|2130230_2130407_-\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	2.2e-22	98.3
WP_000750406.1\|2130515_2131289_-	staphylococcal enterotoxin type A	A0EX09	Staphylococcus_phage	2.2e-146	100.0
WP_000340977.1\|2131709_2132084_-	hypothetical protein	G4KNR3	Staphylococcus_phage	3.3e-39	100.0
WP_001040259.1\|2132139_2132427_-	hypothetical protein	G4KNR2	Staphylococcus_phage	9.9e-44	100.0
WP_001153681.1\|2132473_2132626_-	hypothetical protein	D2JLG0	Staphylococcus_phage	5.2e-20	100.0
WP_000582190.1\|2132615_2136401_-	hypothetical protein	A0EX05	Staphylococcus_phage	0.0e+00	100.0
WP_000567413.1\|2136416_2137901_-\|tail	phage tail family protein	A0EX04	Staphylococcus_phage	4.5e-297	100.0
WP_010956610.1\|2137897_2142427_-\|tail	phage tail tape measure protein	A0EX03	Staphylococcus_phage	0.0e+00	99.9
WP_001549167.1\|2142483_2142621_-	hypothetical protein	A0A2I6PDX7	Staphylococcus_phage	3.4e-18	100.0
WP_001096355.1\|2142671_2143022_-	hypothetical protein	G4KNQ8	Staphylococcus_phage	7.8e-59	100.0
WP_071621395.1\|2143071_2143296_-	Ig-like domain-containing protein	A0A075LYE8	Staphylococcus_phage	3.0e-32	100.0
WP_000268735.1\|2143337_2143982_-\|tail	phage tail protein	A0EWZ9	Staphylococcus_phage	3.8e-120	100.0
WP_000565498.1\|2143982_2144390_-	hypothetical protein	G4KNQ6	Staphylococcus_phage	7.1e-72	100.0
WP_000755150.1\|2144786_2145149_-\|head,tail	head-tail adaptor protein	G4KNQ4	Staphylococcus_phage	4.4e-65	100.0
WP_000150936.1\|2145132_2145417_-\|head,tail	phage head-tail adapter protein	A0A2I6PDJ5	Staphylococcus_phage	2.3e-45	100.0
WP_000238236.1\|2145406_2145691_-	hypothetical protein	A0A2I6PDJ3	Staphylococcus_phage	1.8e-45	100.0
WP_000154559.1\|2145710_2146856_-\|capsid	phage major capsid protein	G4KNQ3	Staphylococcus_phage	9.6e-215	100.0
WP_000642728.1\|2146879_2147617_-\|protease	Clp protease ClpP	G4KNQ2	Staphylococcus_phage	1.8e-129	100.0
WP_000025279.1\|2147600_2148788_-\|portal	phage portal protein	A0A2I6PDI1	Staphylococcus_phage	9.6e-218	99.5
WP_000625088.1\|2148803_2150465_-\|terminase	terminase large subunit	A0A2I6PDJ8	Staphylococcus_phage	0.0e+00	100.0
WP_000402904.1\|2150461_2150806_-	hypothetical protein	G4KNP9	Staphylococcus_phage	9.4e-57	100.0
WP_000988336.1\|2150935_2151235_-	HNH endonuclease	A0EWY8	Staphylococcus_phage	4.6e-52	100.0
WP_000590122.1\|2151466_2151883_-	hypothetical protein	G4KNP7	Staphylococcus_phage	1.3e-76	100.0
WP_000265043.1\|2151910_2152111_-	DUF1514 family protein	A0A2I6PDV9	Staphylococcus_phage	1.4e-28	100.0
WP_000595265.1\|2152110_2152260_-	transcriptional activator RinB	A0A1W6JPZ2	Staphylococcus_phage	4.8e-18	100.0
WP_000592207.1\|2152256_2152643_-	hypothetical protein	W5R986	Staphylococcus_phage	3.0e-64	100.0
WP_000195803.1\|2152639_2152846_-	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
WP_000185659.1\|2152882_2153425_-	dUTP pyrophosphatase	A0EWY2	Staphylococcus_phage	1.1e-96	100.0
WP_000028422.1\|2153417_2153600_-	hypothetical protein	A0EWY1	Staphylococcus_phage	2.6e-26	100.0
WP_001065092.1\|2153589_2153841_-	DUF1024 family protein	A0EWY0	Staphylococcus_phage	9.2e-38	98.8
WP_001624242.1\|2153833_2154001_-	hypothetical protein	A0EWX9	Staphylococcus_phage	7.8e-25	100.0
WP_000131366.1\|2154012_2154255_-	hypothetical protein	A0EWX8	Staphylococcus_phage	3.9e-41	100.0
WP_000101274.1\|2154258_2154627_-	hypothetical protein	W5RAK8	Staphylococcus_phage	8.2e-51	100.0
WP_000338531.1\|2154957_2155176_-	hypothetical protein	A0A2I6PDG4	Staphylococcus_phage	1.2e-36	98.6
WP_000934764.1\|2156085_2156556_-	single-stranded DNA-binding protein	A0EWX3	Staphylococcus_phage	7.4e-81	100.0
WP_071621397.1\|2156556_2157174_-	MBL fold metallo-hydrolase	S4SWA4	Staphylococcus_phage	9.1e-87	100.0
WP_000138472.1\|2157254_2158175_-	recombinase RecT	S4SUN6	Staphylococcus_phage	2.3e-166	100.0
WP_000700577.1\|2158176_2160120_-	AAA family ATPase	A0EWX0	Staphylococcus_phage	0.0e+00	100.0
WP_001205732.1\|2160128_2160392_-	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	7.7e-43	100.0
WP_000291503.1\|2160400_2160661_-	DUF1108 family protein	A0EWW8	Staphylococcus_phage	8.9e-44	100.0
WP_000165375.1\|2160641_2160968_-	DUF2482 family protein	W5RAK4	Staphylococcus_phage	1.2e-53	100.0
WP_000066017.1\|2161062_2161224_-	DUF1270 domain-containing protein	D2JGJ6	Staphylococcus_phage	4.3e-20	100.0
WP_001120197.1\|2161220_2161541_-	DUF771 domain-containing protein	A0A2I6PDH6	Staphylococcus_phage	1.5e-56	100.0
WP_000275058.1\|2161599_2162232_+	hypothetical protein	A7TW95	Staphylococcus_phage	1.5e-113	100.0
WP_000939496.1\|2162246_2162387_-	hypothetical protein	A0A2I6PDG0	Staphylococcus_phage	1.9e-16	100.0
WP_001148855.1\|2162417_2162615_-	hypothetical protein	Q8SDM8	Staphylococcus_phage	7.0e-33	100.0
WP_001148605.1\|2162630_2163383_-	phage antirepressor KilAC domain-containing protein	M9NTH5	Staphylococcus_phage	1.1e-139	100.0
WP_000128907.1\|2163433_2163763_+	hypothetical protein	M9NS98	Staphylococcus_phage	2.7e-53	100.0
WP_001025874.1\|2163751_2163967_-	DUF2829 domain-containing protein	A0EWV9	Staphylococcus_phage	6.3e-35	100.0
WP_000854072.1\|2163982_2164246_-	helix-turn-helix transcriptional regulator	A0A2I6PF09	Staphylococcus_phage	7.2e-41	100.0
WP_001801500.1\|2164242_2164416_-	hypothetical protein	NA	NA	NA	NA
WP_001031454.1\|2164378_2165092_+	helix-turn-helix transcriptional regulator	M9NUL0	Staphylococcus_phage	1.2e-130	100.0
WP_000759680.1\|2165107_2166040_+	ATP-dependent helicase	A0A2I6PEZ7	Staphylococcus_phage	1.6e-172	99.7
WP_000591749.1\|2166045_2166387_+	hypothetical protein	A0A2I6PF04	Staphylococcus_phage	4.6e-56	100.0
WP_000705248.1\|2166590_2166773_+	hypothetical protein	M9NSW6	Staphylococcus_phage	4.1e-27	100.0
WP_000825947.1\|2166872_2167337_+	hypothetical protein	A0EWV3	Staphylococcus_phage	1.1e-28	100.0
WP_000857191.1\|2167395_2168433_+\|integrase	site-specific integrase	A0EWV2	Staphylococcus_phage	9.1e-180	100.0
WP_102948857.1\|2168463_2169315_+	sphingomyelin phosphodiesterase	A0A1P8L6H7	Staphylococcus_phage	2.2e-155	99.3
WP_000595617.1\|2169571_2170591_-	leukocidin/hemolysin toxin family protein	A0A2I6PEU3	Staphylococcus_phage	3.4e-54	39.6
WP_000791402.1\|2170612_2171668_-	succinyl-diaminopimelate desuccinylase	A0A2I6PER8	Staphylococcus_phage	7.9e-38	34.6
WP_000206618.1\|2172099_2173323_+	ArgE/DapE family deacylase	NA	NA	NA	NA
WP_001045073.1\|2173761_2175069_+	TrkH family potassium uptake protein	NA	NA	NA	NA
2173540:2173559	attR	NA	NA	NA	NA
WP_001573771.1\|2175646_2175988_-	hypothetical protein	C8CH40	Staphylococcus_phage	4.1e-20	46.0
WP_001573769.1\|2175977_2176274_-	hypothetical protein	C8CH40	Staphylococcus_phage	6.7e-11	40.4
WP_000201397.1\|2176270_2176450_-	hypothetical protein	NA	NA	NA	NA
WP_000240651.1\|2176991_2178608_-	chaperonin GroEL	A0A240F779	uncultured_virus	2.6e-157	54.7
WP_000917289.1\|2178683_2178968_-	co-chaperone GroES	A0A221S386	uncultured_virus	4.7e-14	46.2
WP_000197638.1\|2179142_2179886_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_002952

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection