CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_002951	Staphylococcus aureus subsp. aureus COL, complete sequence	11 crisprs	cas3,DEDDh,DinG,csa3,WYL	11	4	9	0
NC_006629	Staphylococcus aureus subsp. aureus COL plasmid pT181, complete sequence	0 crisprs	NA	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_002951_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002951_1

457477-457577

Orphan

Consensus_repeat	Method
TTATGAATTGAGTATTAAATTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_002951_1

>merge|NC_002951|1|457477-457577|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTGAAAGTAAATTACAGTTCTATAGGTTTATAAAAATCAGTTTTTAAATCAAAGCTATATATGAATTGAGTATTAAATTTG

>NC_002951|1|1|457477-457577|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTG	AAAGTAAATTACAGTTCTATAGGTTTATAAAAATCAGTTTTTAAATCAAAGCTAT
ATATGAATTGAGTATTAAATTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_002951.2\|WP_000746687.1\|450721_451348_-\|NDxxF-motif-lipoprotein	unknown	unknown	gnl\|CDD\|380196
NC_002951.2\|WP_000930486.1\|451792_453316_-\|alkyl-hydroperoxide-reductase-subunit-F	unknown	unknown	gnl\|CDD\|237942
NC_002951.2\|WP_000466748.1\|448759_449011_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NC_002951.2\|WP_000264071.1\|462275_463742_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NC_002951.2\|WP_000394698.1\|458667_459330_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000868248.1\|450083_450467_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000421410.1\|460391_460970_+\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181705
NC_002951.2\|WP_001789518.1\|456701_456803_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_001289311.1\|454392_455148_+\|NADPH-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|380322
NC_002951.2\|WP_000424966.1\|463766_465308_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NC_002951.2\|WP_000159787.1\|467452_467725_-\|transposase	unknown	unknown	gnl\|CDD\|225511
NC_002951.2\|WP_000041883.1\|466349_467054_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NC_002951.2\|WP_000763768.1\|459472_459880_-\|general-stress-protein	unknown	unknown	gnl\|CDD\|378584
NC_002951.2\|WP_000793009.1\|460969_462238_+\|purine-permease	unknown	unknown	gnl\|CDD\|274468
NC_002951.2\|WP_000956132.1\|457593_458550_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235334
NC_002951.2\|WP_000211676.1\|449049_449259_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000551776.1\|465420_465957_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000052781.1\|453331_453901_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|211789
NC_002951.2\|WP_000991007.1\|455228_456617_-\|L-cystine-transporter	unknown	unknown	gnl\|CDD\|224736
NC_002951.2\|WP_000158374.1\|449436_450018_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483

Protein	Function_ID	Function_description	E-value
NC_002951.2\|WP_000746687.1\|450721_451348_-\|NDxxF-motif-lipoprotein	gnl\|CDD\|380196	NF033193, lipo_NDxxF, NDxxF motif lipoprotein. Members of this family are lipoproteins, about 200 amino acids long in precursor form, found in Staphylococcus aureus, Bacillus cereus, and various other Firmicutes. The protein family is named for one of its several highly conserved motifs.	1.67126e-71
NC_002951.2\|WP_000930486.1\|451792_453316_-\|alkyl-hydroperoxide-reductase-subunit-F	gnl\|CDD\|237942	PRK15317, PRK15317, alkyl hydroperoxide reductase subunit F; Provisional.	0
NC_002951.2\|WP_000466748.1\|448759_449011_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	1.58864e-09
NC_002951.2\|WP_000264071.1\|462275_463742_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NC_002951.2\|WP_000421410.1\|460391_460970_+\|xanthine-phosphoribosyltransferase	gnl\|CDD\|181705	PRK09219, PRK09219, xanthine phosphoribosyltransferase; Validated.	9.01486e-119
NC_002951.2\|WP_001289311.1\|454392_455148_+\|NADPH-dependent-oxidoreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	5.03864e-88
NC_002951.2\|WP_000424966.1\|463766_465308_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NC_002951.2\|WP_000159787.1\|467452_467725_-\|transposase	gnl\|CDD\|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	9.23077e-11
NC_002951.2\|WP_000041883.1\|466349_467054_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	9.65175e-08
NC_002951.2\|WP_000763768.1\|459472_459880_-\|general-stress-protein	gnl\|CDD\|378584	pfam11181, YflT, Heat induced stress protein YflT. YflT is a heat induced protein.	2.0219e-12
NC_002951.2\|WP_000956132.1\|457593_458550_-\|hypothetical-protein	gnl\|CDD\|235334	PRK05035, PRK05035, electron transport complex protein RnfC; Provisional.	0.000748442
NC_002951.2\|WP_000793009.1\|460969_462238_+\|purine-permease	gnl\|CDD\|274468	TIGR03173, pbuX, xanthine permease. All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.	2.75897e-170
NC_002951.2\|WP_000052781.1\|453331_453901_-\|peroxiredoxin	gnl\|CDD\|211789	TIGR03137, AhpC, peroxiredoxin. This peroxiredoxin (AhpC, alkylhydroperoxide reductase subunit C) is one subunit of a two-subunit complex with subunit F(TIGR03140). Usually these are found as an apparent operon. The gene has been characterized in Bacteroides fragilis, where it is important in oxidative stress defense. This gene contains two invariant cysteine residues, one near the N-terminus and one near the C-terminus, each followed immediately by a proline residue. [Cellular processes, Detoxification, Cellular processes, Adaptations to atypical conditions].	1.50623e-124
NC_002951.2\|WP_000991007.1\|455228_456617_-\|L-cystine-transporter	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	0
NC_002951.2\|WP_000158374.1\|449436_450018_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	2.78414e-49

>NC_002951.2|WP_001789518.1|456701_456803_+|hypothetical-protein
MQLNVNMMKFDRWHKGICKQIVLNSVVIGGKGK
>NC_002951.2|WP_000991007.1|455228_456617_-|L-cystine-transporter
MNAFLTLINIIVLVIFIVILHMMARKHISFAKRVFTALGIGIVFGVLLHLIYGTHSNVITSTSDWFNIVGQGYVALLQMIVMPLIFISIVAAFTKIQIGEKFAKIGSLIFIFLIGTVTIAAIVGVVYALVFGLDASTINLGNAEQARGSEIAKQAKDLTAHTLPQQILELLPKNPFLDFTGQRATSTIAVVIFASFIGFAYLRVARKQPDHGELLKRAIDAIYSLVMAIVTFVLRLTPYGVLAIMANTLSTSDFGAIWTLGKFLIASYAALITMYIIHLIILSLLGISPIRYVKKTLEVLIFAFTSRSSAGALPLNVQTQTRRLGVPEGIANFAATFGLSIGQNGCAGIYPAMLAIMVAPVANVEIDLQFIVTLIAVVIISSFGVAGVGGGATFASILVLSTLNLPVALAGVLISVEPLIDMGRTALNVNDSMLAGTGTAKLTKHWDKDTFDSNDNAALTSH
>NC_002951.2|WP_001289311.1|454392_455148_+|NADPH-dependent-oxidoreductase
MSEHVYNLVKKHHSVRKFKNKPLSEDVVKKLVEAGQSASTSSFLQAYSIIGIDDEKIKENLREVSGQPYVVENGYLFVFVIDYYRHHLVDQHAETDMENAYGSTEGLLVGAIDAALVAENIAVTAEDMGYGIVFLGSLRNDVERVREILDLPDYVFPVFGMAVGEPADDENGAAKPRLPFDHVFHHNKYHADKETQYAQMADYDQTISEYYDQRTNGNRKETWSQQIEMFLGNKARLDMLEQLQKSGLIQR
>NC_002951.2|WP_000052781.1|453331_453901_-|peroxiredoxin
MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLAQRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQPGLDLVGKI
>NC_002951.2|WP_000930486.1|451792_453316_-|alkyl-hydroperoxide-reductase-subunit-F
MLNADLKQQLKQLLELMEGNVEFVASLGSDDKSKELKDLLTEITDMSPRLSLSEKSLKRTPSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKKLEGSFHFETFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNGRMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGGQVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENGAVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEAAIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYEDMNTGEEHLLNLDGIFVQIGLLPNTSWLNDAVELNERGEIVIDRNNNTNVPGIFAAGDVTDQKNKQIIISMGAGANAALNAFDYIIRN
>NC_002951.2|WP_000746687.1|450721_451348_-|NDxxF-motif-lipoprotein
MKKRLLLSTFLASTLILTGCASDQSDNEDHHTSTGIHAPKSAKKLETKDIFNSDKKNSDISDAEMKQAIEKYLSVNSDILDNKYIMQHKLDKQIDSQTKVTEKQAETLSHLSNLAVKNDLHFKKFVTENNIPKEYKKPVELMMNYFKALNSTIANVDEDIEKLSYQPQNKINVVDVPTKYAGDVNKKQQDKIKDFLKSKGIKSDVIDK
>NC_002951.2|WP_000868248.1|450083_450467_-|hypothetical-protein
MKVRITFIILAILSTIVCLFLAAMHPTGPNTVTFEQPYLFTLNIIIMVLVALPSLVLAIYDYMSFRISSAILQFLGAISWFFLSLILSLTQFTPFTLASFITSIILFTSTIITLAIGGKSVEKNDSP
>NC_002951.2|WP_000158374.1|449436_450018_+|histidine-phosphatase-family-protein
MTIYLVRHGESKSNYDNKHFRSYFCGQLDVPLTDTGTKSADDLCDYFKEKQIKHVYVSDLLRTQQTFEHIFPYDIASTTTPLLRERSLGVFEGEYKDEISANPKYEKYFNDPNFKDFRHSFSQKAPEGESYEDVYQRVEHFMNHVVNEDTQKDDIVIVAHQVVIRCLMVYFNKVSRAEAVDLKVENCKPYIIE
>NC_002951.2|WP_000211676.1|449049_449259_-|hypothetical-protein
MTTQSFIFMNIILLDGATQRHPFFICQILAFLFPKFPHINLLLFNPILSTFSNIIIHIDHFHANKKDDN
>NC_002951.2|WP_000466748.1|448759_449011_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MFGFIGMLIVGGLIGWAAGAIMGKDIPGGILGNIIAGIIGSWVGGKLFGQWGPELGSIYILPALIGSIILIAIVTLILRAMRK
>NC_002951.2|WP_000956132.1|457593_458550_-|hypothetical-protein
MLTKEFAQRVELSEKQVRKIVQHLEERGYQLSKTEYRGREATDFKEEDIELFKDIADKVKQTNSYDLAFDELEKEKDFLQVIVKNDDKNLPTNQNVAQLVEDLRLEIQKMREERHLLGQMMNQVHQQQQELKELQNQLTSKIDSNSESLKAIQTSQEAIQEAQASQAKALAESTNKVEKNAVTEDKADSKDSKVAGVNTSTDAKTDTKAENAGDGTATKVDKEDQISATEAIEKASVEQSKNDNAAETSNKEATVDAEAQHDAEQQVAEAHAEASKQATSNDSLEAKAENDSTASQSEMSEPKPQEEKKGFFARLFNL
>NC_002951.2|WP_000394698.1|458667_459330_-|hypothetical-protein
MEFKTIQSVKDPHYNEALKLYDTKLNLSLTEDKRIIKRSLENNKTENDYVFIVGLENDVVVSLATAHYEATTNSAFLIYLFAKDLPNHDELMTQTLHQIEHELNLLSNLVHSRSINFLMMEVPKEPADLTQDNGLIIEHRRQFLYEHQFERQTEIDYIHPTNDGHTKKVDLFLKKNIKLTKDIYGTSVKSNYILKYVFANGIAREIIYALLEEMDLRKPF
>NC_002951.2|WP_000763768.1|459472_459880_-|general-stress-protein
MADITVVNDTGELYNVINQKKSEGYLESELTIISKSKLHLNDLHDSEISLISTSGTFSDRMTKLLTGEDGEHAVLSRYNLAPDELEKYKQLILDDKMLVVAVRDKSSHQEVHENNSAYEEIDITHFAEASKGPKA
>NC_002951.2|WP_000421410.1|460391_460970_+|xanthine-phosphoribosyltransferase
MELLGQKVKEDGVVIDEKILKVDGFLNHQIDAKLMNEVGRTFYEQFKDKGITKILTIEASGIAPAIMAALHFDVPCLFAKKAKPSTLTDGYYETSIHSFTKNKTSTVIVSKEFLSEEDTVLIIDDFLANGDASLGLYDIAQQANAKTAGIGIVVEKSFQNGHQRLEEAGLTVSSLCKVASLEGNKVTLVGEE
>NC_002951.2|WP_000793009.1|460969_462238_+|purine-permease
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILIGQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTLIIILLLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIESTGVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLLICGCIPKLGALANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAISAIILNFFFNGIKYKQTEENVK
>NC_002951.2|WP_000264071.1|462275_463742_+|IMP-dehydrogenase
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQENLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQITKESPNYSF
>NC_002951.2|WP_000424966.1|463766_465308_+|glutamine-hydrolyzing-GMP-synthase
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCRGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHKAIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEVLQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
>NC_002951.2|WP_000551776.1|465420_465957_-|hypothetical-protein
MHNNNEFNKKLKDFIGSDKRMALVKGYVNEYKLTTVLRALNNSDYTKGTIHTRSIGNLKQIVDNRIIPKNITQNTIFKLSNLTLEVNLYERNTIYHGDFAIYYPVESALIIETDTPRLINHINNNPVQKIFIITTNDWSFNTLELEKIVDETIIYDLKQEDPKQYEILYKNKHGKLPY
>NC_002951.2|WP_000041883.1|466349_467054_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MSKNINQANSKLNTSNKKLKQAYSKSDSKNMKVIYMPHWLEFYSIAIHSDVTSNKKRYYKSYSRGTVVYVKLGSNIGSEFSGNHFCVILDNKDNKGKETVTIVPLSSKGNKNYLKLNESVLNLTATDLKKQIIDISSKVQALAQKYREIDIKLSTEDKKLLSNLNQKANELYRVIGVYSKHKGKDTYVNISAITTISKRRISKINDSDPTGTIIISEDDMNEIEKQLKIKFFSN
>NC_002951.2|WP_000159787.1|467452_467725_-|transposase
MTKERRTFSSEFKLQMVRLYKNGKLKNEIIRKYDLKPSIISNSIKQHQNTGPFNHQDNLKSDEKELIKLRKEVQHLKMEHDVLKQILKLI

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Crispr_ID: NC_002951_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002951_2

693544-693636

Orphan

Consensus_repeat	Method
CTAAAGGTGAAGAGGAACGCAGTTGGATGCTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_002951_2

>merge|NC_002951|2|693544-693636|CRISPRCasFinder
CTAAAGGTGAAGAGGAACGCAGTTGGATGCTAAGGCACAACTGCATAAAAGCCTCTAATCGCTAAAGATGAAGAGGAACGCAGTTGGATGCTA

>NC_002951|2|2|693544-693636|CRISPRCasFinder
CTAAAGGTGAAGAGGAACGCAGTTGGATGCTA	AGGCACAACTGCATAAAAGCCTCTAATCG
CTAAAGATGAAGAGGAACGCAGTTGGATGCTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_002951.2\|WP_001222133.1\|698051_698768_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000477504.1\|686083_686560_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_002951.2\|WP_001200748.1\|688942_689953_+\|alcohol-dehydrogenase-AdhP	unknown	unknown	gnl\|CDD\|181842
NC_002951.2\|WP_000365354.1\|695744_696464_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NC_002951.2\|WP_000655099.1\|690027_690135_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000735558.1\|697383_697890_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_001021145.1\|690640_692302_+\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234964
NC_002951.2\|WP_000901764.1\|692690_693326_+\|endonuclease-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|225140
NC_002951.2\|WP_000633782.1\|685378_685915_+\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NC_002951.2\|WP_000749059.1\|693704_694592_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238563
NC_002951.2\|WP_001788287.1\|687922_688444_+\|YwhD-family-protein	unknown	unknown	gnl\|CDD\|378039
NC_002951.2\|WP_000180230.1\|686599_687895_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224004
NC_002951.2\|WP_000808902.1\|684229_685168_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381309
NC_002951.2\|WP_000169042.1\|702421_702646_-\|DUF2922-domain-containing-protein	unknown	unknown	gnl\|CDD\|378571
NC_002951.2\|WP_001790232.1\|694739_695690_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_002951.2\|WP_001045421.1\|698936_699725_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_002951.2\|WP_001018677.1\|699975_700350_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|130944
NC_002951.2\|WP_001553862.1\|701297_702227_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|225778
NC_002951.2\|WP_000359086.1\|690227_690644_+\|DUF1934-domain-containing-protein	unknown	unknown	gnl\|CDD\|226896
NC_002951.2\|WP_000362967.1\|696447_697248_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669

Protein	Function_ID	Function_description	E-value
NC_002951.2\|WP_000477504.1\|686083_686560_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.13315e-11
NC_002951.2\|WP_001200748.1\|688942_689953_+\|alcohol-dehydrogenase-AdhP	gnl\|CDD\|181842	PRK09422, PRK09422, ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional.	0
NC_002951.2\|WP_000365354.1\|695744_696464_+\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	3.6864e-38
NC_002951.2\|WP_000359086.1\|690227_690644_+\|DUF1934-domain-containing-protein	gnl\|CDD\|226896	COG4506, COG4506, Uncharacterized protein conserved in bacteria [Function unknown].	2.62525e-58
NC_002951.2\|WP_001021145.1\|690640_692302_+\|arginine--tRNA-ligase	gnl\|CDD\|234964	PRK01611, argS, arginyl-tRNA synthetase; Reviewed.	0
NC_002951.2\|WP_000901764.1\|692690_693326_+\|endonuclease-III-domain-containing-protein	gnl\|CDD\|225140	COG2231, COG2231, Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair].	3.98158e-90
NC_002951.2\|WP_000633782.1\|685378_685915_+\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	3.16348e-26
NC_002951.2\|WP_000749059.1\|693704_694592_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238563	cd01143, YvrC, Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.	8.54601e-73
NC_002951.2\|WP_001788287.1\|687922_688444_+\|YwhD-family-protein	gnl\|CDD\|378039	pfam08741, YwhD, YwhD family. This family of proteins are currently uncharacterized. They are around 170 amino acids in length.	8.7406e-98
NC_002951.2\|WP_000180230.1\|686599_687895_+\|HD-domain-containing-protein	gnl\|CDD\|224004	COG1078, COG1078, HD superfamily phosphohydrolases [General function prediction only].	1.70707e-150
NC_002951.2\|WP_000808902.1\|684229_685168_+\|aldo/keto-reductase	gnl\|CDD\|381309	cd19083, AKR_AKR11A1_11D1, AKR11A and AKR11D families of aldo-keto reductase (AKR). Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).	7.3194e-168
NC_002951.2\|WP_000169042.1\|702421_702646_-\|DUF2922-domain-containing-protein	gnl\|CDD\|378571	pfam11148, DUF2922, Protein of unknown function (DUF2922). This bacterial family of proteins has no known function.	1.74707e-13
NC_002951.2\|WP_001018677.1\|699975_700350_-\|transcriptional-regulator	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	1.77309e-26
NC_002951.2\|WP_001045421.1\|698936_699725_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.55978e-34
NC_002951.2\|WP_001553862.1\|701297_702227_-\|DMT-family-transporter	gnl\|CDD\|225778	COG3238, COG3238, Uncharacterized protein conserved in bacteria [Function unknown].	7.93315e-37
NC_002951.2\|WP_001790232.1\|694739_695690_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	5.19191e-48
NC_002951.2\|WP_000362967.1\|696447_697248_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.17592e-26

>NC_002951.2|WP_000901764.1|692690_693326_+|endonuclease-III-domain-containing-protein
MLGTDELYKVLYEHLGPQFWWPADNDIEMMLGAILVQNTRWRNAEIALNQIKEHTHFNPNHILELPIETLQSLIHSSGFYKSKSLTIKTLLTWLARHHFNYQEINERYKGGLRKELLSLKGIGSETADVLLVYIFGRIEFIPDSYTRKIYDKLGYENTKNYDQLKKVVTLPNHFTNQDANEFHALLDVFGKHYFRDKDIKNYDFLEPYFKK
>NC_002951.2|WP_001021145.1|690640_692302_+|arginine--tRNA-ligase
MNIIDQVKQTLVEEIAASINKAGLADEIPDIKIEVPKDTKNGDYATNIAMVLTKIAKRNPREIAQAIVDNLDTEKAHVKQIDIAGPGFINFYLDNQYLTAIIPEAIEKGDQFGHVNESKGQNVLLEYVSANPTGDLHIGHARNAAVGDALANILTAAGYNVTREYYINDAGNQITNLARSIETRFFEALGDNSYSMPEDGYNGKDIIEIGKDLAEKHPEIKDYSEEARLKEFRKLGVEYEMAKLKNDLAEFNTHFDNWFSETSLYEKGEILEVLAKMKELGYTYEADGATWLRTTDFKDDKDRVLIKNDGTYTYFLPDIAYHFDKVKRGNDILIDLFGADHHGYINRLKASLETFGVDSNRLEIQIMQMVRLMENGKEVKMSKRTGNAITLREIMDEVGVDAARYFLTMRSPDSHFDFDMELAKEQSQDNPVYYAQYAHARICSILKQAKEQGIEVTAANDFTTITNEKAIELLKKVADFEPTIESAAEHRSAHRITNYIQDLASHFHKFYNAEKVLTDDIEKTKAHVAMIEAVRITLKNALAMVGVSAPESM
>NC_002951.2|WP_000359086.1|690227_690644_+|DUF1934-domain-containing-protein
MDKKVSIQTKQVLKQHNEKEKFEFTTEGTWQQRQSNFIRYVEQIEDATVNVTIKVDDDSVKLIRKGDINMNLHFVEGQTTTTFYDISAGRIPLEVKTLRILHFVSGDGGKLKIHYELYQDNEKMGSYQYEINYKEIGE
>NC_002951.2|WP_000655099.1|690027_690135_+|hypothetical-protein
MKDSENLVFFGFEVLFVFYKMAYIYEALIKYGIVN
>NC_002951.2|WP_001200748.1|688942_689953_+|alcohol-dehydrogenase-AdhP
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
>NC_002951.2|WP_001788287.1|687922_688444_+|YwhD-family-protein
MEVISLSEKKGFNFNIIKNDPLDGHKGTNIGSISLDNIAPVFIDVANKEAFIDIGGMHARAKVEKGVKWITDKAAVEGDEAKEYWLCWVTTERNEQGPYYAGLTACYLLVNKAIRRGYKSMPEHVNMMDKSMKHHIIIDQIGDENKAILKDFLMNHDEGMWKHSSDALHQAFN
>NC_002951.2|WP_000180230.1|686599_687895_+|HD-domain-containing-protein
MTNAYVDLKLVEEKVFKDPIHRYIHVEDQLIWDLIKTKEFQRLRRIRQLGTLYLSFHTAEHSRFGHSLGVYEIVRRLIDESFIGHDAWDNKDRPLALCAALLHDLGHGPFSHSFEKIFNTDHEAYTQAIITGDTEVNAVLRKVAPEFPREVAEVINKTHHNKLVISMISSQIDADRMDYLQRDAYFTGVSYGAFDMERILRLMRPSKDEVLIKESGMHAVENFIMSRYQMYWQIYFHPVSRGGEVLLNNCLKRAKQLYNEGYEFKLHPHDFIPFFEETVTIEQYVELDEAVVTYYLEKWTKEDDAILSDLASRFINRDLFKYIPFDGSIITISELQELFEAGGINPDYYFVSEAFSDLPYDYDRPGSNRKPIHLLRQDGTIREISNQSLVIHSITGINRQDYKLYYPREMVAKIKDKTIREAIENLINELN
>NC_002951.2|WP_000477504.1|686083_686560_+|GNAT-family-N-acetyltransferase
MFKVRQATEKDVVQIRDVATKAWFNTYLNIYAATTVNHLLEASYNEHHLKKRLQEQLFLVVEEGNDIVGFANFIYGEELYLSAHYVKPESQHTGYGTALLNEGLSRFEDKFEGVYLEVDNKNEEAVAYYKEQGFTILRSYEPEMYGEKLDLALMYKAF
>NC_002951.2|WP_000633782.1|685378_685915_+|flavodoxin-family-protein
MITVLFGGSRPNGNTAQLTKFALQDLEYQWIDVTQHQFKPIRDVRHTAETITSYDDDYLPILDKILASDTIIFASPVYWYSISAPLKAFIEHWSETLQDKRYPNFKAQMAEKDFRVILVGGDCPKIKAKPAITQMKYSLDFLGATLNGYIIGTAEKPGDIMKDNYALARATEWNSILQ
>NC_002951.2|WP_000808902.1|684229_685168_+|aldo/keto-reductase
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYGPERSEELVGEVVKEYPREQIKIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDNNTPKDQAVAALQELKEQGKIKAIGVSNFTLDQLKEANKDGYVDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLASGILAGKYDENTKFSDHRTTRRDFKPGVFEENVRRVKALESIAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDEIQYIDELFPIED
>NC_002951.2|WP_000749059.1|693704_694592_+|ABC-transporter-substrate-binding-protein
MKKSLIAFILIFMLVLSGCGMKDNDKQGSNDNGSSKSPYHRIVSLMPSNTEILYELGLGKYIVGVSTVDDYPKDVKKGKKQFDALNLNKEELLKAKPDLILAHESQKATANKVLSSLEKQGIKVVYVKDAQSIDETYNTFKQIGKLTHHDKQAEQLVEETKDNIDKVIDSIPAHHKKSKVFIEVSSKPEIYTAGKHTFFNDMLEKLEAQNVYSDINGWNPVTKESIIKKNPDILISTEAKTRSDYMDIIKKRGGFNKINAVKNTRIEVVNGDEVSRPGPRIDEGLKELRDAIYRK
>NC_002951.2|WP_001790232.1|694739_695690_+|iron-ABC-transporter-permease
MTFNKVLLSWIVILIITTSIYLFWQLGDINDVFNQSILINVRLPRLLEALLTGMILTVAGLIFQTVLNNALADSFTLGLASGATFGSGLALFLGLTTLWIPVFSITFSLITLITVLVITSVLSQGYPVRILILSGLMIGALFNSLLYFLILLKPRKLNTIANYLFGGFGDAEYSNVSIIAITFIIALFGIFIILNQLKLLQLGELKSQSLGLNVQLITYIALCIASMITAINVAYVGIIGFIGMVIPQLIRKWQWKQSLGRQLALNIVTGGQIMVMADFIGSHILSPVQIPASIIIALIGIPVLFYMLISQSKRLH
>NC_002951.2|WP_000365354.1|695744_696464_+|HAD-family-hydrolase
MDLNQIKAVVFDLEGTLLDRVKSREKFIEEQYERFHDYLIHVQLADFKKAFIELDDDEDNDKPDLYKEIIKRFHVDRLTWKDLFNDFEMHFYRYVFPYYDTLYTLEKLSQKGFQIGVIANGKSKIKQFRLHSLGLMHVINYLSTSETVGFRKPHPKIFEDMIDQLGVLPEQIMYVGDDALNDVAPARAMGMVSVWYKQEDAEIEPLEEEVDFTITTVEELLTILPIKNDNKGENYGSIY
>NC_002951.2|WP_000362967.1|696447_697248_+|alpha/beta-hydrolase
MDLFTRKDGTSIHYSTLGEGYPIVLIHTVLDNYSVFNKLAAELAKSFQVVLIDLRGHGYSDKPRHIEIKDFSDDIVELLKYLYIEEVAFVCHEMGGIIGADISVRYPEFTSSLTLVNPTSIEGELPEERLFRKYAHIIRNWDPEKQDKFLNKRKYYRPRKMNRFLKHVVDTNEISTKEEIQAVKEVFKNADISQTYRNVVVPTKIIAGEFGERTTRLEAKEVADLIQNADFEVYQESSAFPFVEEQERFVEDTAAFINKHHDEKHV
>NC_002951.2|WP_000735558.1|697383_697890_+|hypothetical-protein
MKKLLTASIIACSVVMGVGLVNTSAEAASGNSIDTVKQLIKGDQSLENVKIGESIKDVLTKYKNPMYSYNEDGTEHYYEFHTKKGMLLVTTDGKKNNGKVTHISMMYNDANGPTYQAVKNYVGKAVTHTEYSKVAGNFGYIEKGKTTYQFASAPKDKNIKLYRIDLEK
>NC_002951.2|WP_001222133.1|698051_698768_+|hypothetical-protein
MRINDKILLENIEDYFNHKGLSPHLIDDIKEKVITDIKNSEKKDQDYIEYKRKSPAQIILMIQRNLFALQMNPVIFFIINFILISYLYDKQYVQFQAITGMSLFYCLVIFPMTIVVYLRVSQKNYLRSNKIEMIMGTIIAIISLLLIILQAFNITWGVIPITNFGHQFFFFIGIILVIAGIFYKRLEFSGIGLLFCQKTVDAMIHNPQSAQIFSLIIWILLVVLVIYFTIRLSSRTRL
>NC_002951.2|WP_001045421.1|698936_699725_+|alpha/beta-hydrolase
MNKVTINPQIQLTYQIEGKGDPIILLHGLDGNLAGFEDLQHQLASSYKVLTYDLRGHGKSSKSESYDLNDHVEDLKILMEKLNIHEAHILGHDLGGVVAKLFTDKYAYRVKSLTTIASKKDDLIHSFTQLLIQYQDDIAGFNKSEAYILLFSKLFRNQEKTMKWYQKQRIYSIKSEDDSAVAIRSLILHKDEPMYLKKRTCVPTLLINGEHDPLIKDKNHFKLEAHFLNVTKKIFEHSGHAPHIEEPEAFMNYYLKFLKSVS
>NC_002951.2|WP_001018677.1|699975_700350_-|transcriptional-regulator
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL
>NC_002951.2|WP_001553862.1|701297_702227_-|DMT-family-transporter
MLLFYIIGVLVGMLIPIQTSVNSRLSLYTKSPFYTSFISFSVGTICLIILNIIINPEVFTIHFYNNQSFNYTWVVGGLLGVSFLTGNLLLLPKLGATLTVIATVAGQIIMGVIIDTFGLFGATIHDFNLIKAIGVLLLIVGIVIMNQFNKNNLLLTDQKYLLFWLLLGFIFGFFPPIQTTINSALASHTHSPAFASLVSFTIGSIALLILTAIFNRSLKLKTSHLKFGKLKPIYFTGGILGMAFVTANIILMPHMGAALTTLIGMFGQILMGILIDHFGLFGSPKIAMTSRKTIGLLCILTGIILLRLF
>NC_002951.2|WP_000169042.1|702421_702646_-|DUF2922-domain-containing-protein
MTKTLELSFKSSLDKPVKLQLPQLNNVVTEQVARDSMNALVDLNIIKSNSGTITKVHSAQIIDKTTTVLFEDKK

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Crispr_ID: NC_002951_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002951_3

809623-809705

Orphan

Consensus_repeat	Method
CCAATTTCTACAGACAATGCAAGTTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_002951_3

>merge|NC_002951|3|809623-809705|CRISPRCasFinder
CCAATTTCTACAGACAATGCAAGTTGGCGGGGCCCCAACATAGAGAAATTGGAACGCCAATTTCTACAGACAATGCAAGTTGG

>NC_002951|3|3|809623-809705|CRISPRCasFinder
CCAATTTCTACAGACAATGCAAGTTGG	CGGGGCCCCAACATAGAGAAATTGGAACG
CCAATTTCTACAGACAATGCAAGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_002951.2\|WP_001068497.1\|813706_814573_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NC_002951.2\|WP_000663030.1\|807522_808581_+\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|235106
NC_002951.2\|WP_000589254.1\|804798_805776_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224050
NC_002951.2\|WP_000876318.1\|819636_820608_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226965
NC_002951.2\|WP_000692521.1\|815373_815772_+\|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI	unknown	unknown	gnl\|CDD\|224694
NC_002951.2\|WP_000429014.1\|810153_811071_-\|diacylglycerol-kinase-family-lipid-kinase	unknown	unknown	gnl\|CDD\|224513
NC_002951.2\|WP_000197271.1\|808931_809474_+\|5'-3'-deoxyribonucleotidase	unknown	unknown	gnl\|CDD\|226895
NC_002951.2\|WP_000098285.1\|798689_800630_+\|polyglycerol-phosphate-lipoteichoic-acid-synthase-LtaS	unknown	unknown	gnl\|CDD\|224287
NC_002951.2\|WP_000525109.1\|800900_802784_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_002951.2\|WP_000983677.1\|802795_804577_+\|DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|273594
NC_002951.2\|WP_000562498.1\|817957_818929_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|275027
NC_002951.2\|WP_000855505.1\|815734_817840_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|236069
NC_002951.2\|WP_001790641.1\|811161_811263_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000708692.1\|796517_797228_+\|allophanate-hydrolase-subunit-1	unknown	unknown	gnl\|CDD\|224960
NC_002951.2\|WP_001790169.1\|796223_796430_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000499195.1\|819442_819598_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000180991.1\|805768_807283_+\|ABC-transporter-permease/substrate-binding-protein	unknown	unknown	gnl\|CDD\|270328
NC_002951.2\|WP_000930014.1\|813186_813687_-\|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	unknown	unknown	gnl\|CDD\|223851
NC_002951.2\|WP_000022323.1\|797211_798216_+\|biotin-dependent-carboxyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224895
NC_002951.2\|WP_000193751.1\|811340_812846_-\|peptide-MFS-transporter	unknown	unknown	gnl\|CDD\|225646

Protein	Function_ID	Function_description	E-value
NC_002951.2\|WP_001068497.1\|813706_814573_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	3.8323e-10
NC_002951.2\|WP_000663030.1\|807522_808581_+\|histidinol-phosphate-transaminase	gnl\|CDD\|235106	PRK03158, PRK03158, histidinol-phosphate aminotransferase; Provisional.	0
NC_002951.2\|WP_000589254.1\|804798_805776_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	1.04719e-153
NC_002951.2\|WP_000876318.1\|819636_820608_+\|ABC-transporter-permease	gnl\|CDD\|226965	COG4606, CeuB, ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism].	1.32603e-150
NC_002951.2\|WP_000692521.1\|815373_815772_+\|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI	gnl\|CDD\|224694	COG1780, NrdI, Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism].	5.52807e-56
NC_002951.2\|WP_000429014.1\|810153_811071_-\|diacylglycerol-kinase-family-lipid-kinase	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	3.10512e-78
NC_002951.2\|WP_000197271.1\|808931_809474_+\|5'-3'-deoxyribonucleotidase	gnl\|CDD\|226895	COG4502, COG4502, 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism].	1.15481e-107
NC_002951.2\|WP_000098285.1\|798689_800630_+\|polyglycerol-phosphate-lipoteichoic-acid-synthase-LtaS	gnl\|CDD\|224287	COG1368, MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane].	0
NC_002951.2\|WP_000525109.1\|800900_802784_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0
NC_002951.2\|WP_000983677.1\|802795_804577_+\|DNA-helicase-RecQ	gnl\|CDD\|273594	TIGR01389, recQ, ATP-dependent DNA helicase RecQ. The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_002951.2\|WP_000562498.1\|817957_818929_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	gnl\|CDD\|275027	TIGR04171, ribonucleotide-diphosphate_reductase_subunit_beta, ribonucleoside-diphosphate reductase, class 1b, beta subunit. Members of this family are NrdF, the beta subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	2.30551e-164
NC_002951.2\|WP_000855505.1\|815734_817840_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|236069	PRK07632, PRK07632, ribonucleotide-diphosphate reductase subunit alpha; Validated.	0
NC_002951.2\|WP_000708692.1\|796517_797228_+\|allophanate-hydrolase-subunit-1	gnl\|CDD\|224960	COG2049, DUR1, Allophanate hydrolase subunit 1 [Amino acid transport and metabolism].	1.29969e-94
NC_002951.2\|WP_000180991.1\|805768_807283_+\|ABC-transporter-permease/substrate-binding-protein	gnl\|CDD\|270328	cd13610, PBP2_ChoS, Substrate-binding domain ChoS of an osmoregulated ABC-type transporter and related proteins; type 2 periplasmic-binding protein fold. Osmoprotectant binding lipoprotein ChoS of Lactococcus lactis is predicted to be involved in uptake of compatible solutes such as choline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. ChoS belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.03165e-152
NC_002951.2\|WP_000930014.1\|813186_813687_-\|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	gnl\|CDD\|223851	COG0780, COG0780, Enzyme related to GTP cyclohydrolase I [General function prediction only].	7.91282e-79
NC_002951.2\|WP_000022323.1\|797211_798216_+\|biotin-dependent-carboxyltransferase-family-protein	gnl\|CDD\|224895	COG1984, DUR1, Allophanate hydrolase subunit 2 [Amino acid transport and metabolism].	1.25641e-144
NC_002951.2\|WP_000193751.1\|811340_812846_-\|peptide-MFS-transporter	gnl\|CDD\|225646	COG3104, PTR2, Dipeptide/tripeptide permease [Amino acid transport and metabolism].	1.22605e-172

>NC_002951.2|WP_000197271.1|808931_809474_+|5'-3'-deoxyribonucleotidase
MTRKSIAIDMDEVLADTLGEIIDAVNFRADLGIKMEALNGQKLKHVIPEHDGLITEVLREPGFFRHLKVMPYAQEVVKKLTEHYDVYIATAAMDVPTSFSDKYEWLLEFFPFLDPQHFVFCGRKNIVKADYLIDDNPRQLEIFTGTPIMFTAVHNINDDRFERVNSWKDVEQYFLDNIEK
>NC_002951.2|WP_000663030.1|807522_808581_+|histidinol-phosphate-transaminase
MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYYPETGSPTLKAAISKHLNVDQSRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHNAIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPNNPTGTYFNHESLDSFLSQVPPHVPVIIDEAYFEFVTAEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAIEKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVTHKNSVERERFYQLPQSEYFLPSQTNFIFVKTKRVNELYEALLNVGCITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE
>NC_002951.2|WP_000180991.1|805768_807283_+|ABC-transporter-permease/substrate-binding-protein
MTNFFDILSERKGQLFSTMIEHIQISFIALLIATAIAVPLGILLTKTKTISEIVMNIAAILQTIPSLALLGLMIPLFGIGRVPAIIALVVYALLPILRNTYTGIKEVDPSLIEAAKGIGMKPFRRLTKVELPIAMPVIMAGVRTAMVLIIGTATLAALIGAGGLGDLILLGIDRNNASLILLGAIPAALLAIIFDLILRFMAKLSYKKLLMTLGVIVMIIILAIAIPMFAQKGDKITLAGKLGSEPSIITNMYKILIEEETKNTVEVKDGMGKTAFLFNALKSDDIDGYLEFTGTVLGELTKEPLKSKEEKKVYEQAKQSLEKKYQMTMLKPMKYNNTYALAVKRDFAKQHNIRTIGDLNKVKDQLKPGFTLEFNDRPDGYKAVQKAYNLNLDNIRTMEPKLRYQAINKGNINLIDAYSTDAELKQYDMVVLKDDKHVFPPYQGAPLFKESFLKKHPEIKKPLNKLENKISDEDMQMMNYKVTVKNEDPYTVAKDYLKAKGLIK
>NC_002951.2|WP_000589254.1|804798_805776_+|ABC-transporter-ATP-binding-protein
MIKFKNVTKRYGKHVAVDNISFNINEGEFFVLIGPSGCGKTTTLKMINRLIHLSEGYIYFKDKPISDYPVYEMRWDIGYVLQQIALFPHMTIKENIAQVPQMKKWKEKDIDKRVDELLEMVGLEPEKYKNRKPDELSGGQRQRVGVIRALAADPPVILMDEPFSALDPISREKLQDDLIELQTKIKKAIIFVTHDIQEAMKLGDKICLLNEGHIEQIDTPEGFKNNPQSEFVKQFMGSHLEDDAPCVEENAIIRDLDIMKPIDEVTSMSAYPIVYDNQPIEVLYQLLSESERVIVMQEDSVGQYVIDRKDIFKYLSQKKEVAQHD
>NC_002951.2|WP_000983677.1|802795_804577_+|DNA-helicase-RecQ
MMQQTLSHYFGYETFRPGQEEIISKVLDHRNVLGVLPTGGGKSICYQVPGLLLGGTTIVISPLISLMKDQVDQLKAMGIQAAFLNSSLTQKEQQRIEKALSNGEIQFLYVAPERFENRYFLNMLQRIKIHLVAFDEAHCISKWGHDFRPSYQNVISKVFTLPQDFTIIALTATATVEVQQDIREKLNIAQTDQIKTSTKRRNLIFKVNPTYQRQKFILDYIKTHDEDAGIIYCSTRKQVEELQEALESQKIESVIYHAGLSNKEREEAQNDFLFDRVKVVVATNAFGMGIDKSNVRFVIHYNMPGDLESYYQEAGRAGRDGLKSECILLFSERDINLHEYFITVSQADDDYKDKMGEKLTKMIQYTKTKKCLEATIVHYFEPNEKLEECEQCSNCVQQDKSYNMTQEAKMIISCIARMKQQESYSVIIQVLRGESTDYIKYKGYDQISTHGLMKGYTTSELSHLIDELRFKGFLNENDEILMCDTSIKKLLSNEVEVFTTPFKQKATEKVFINTVEGVDRVLFSQLVEVRKKLSDKLTIAPVSIFSDYTLEEFAKRKPASKQDMINIDGVGSYKLKHYCPAFLETIQNYKAKV
>NC_002951.2|WP_000525109.1|800900_802784_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MGMEAYKIEHLNKSYADKTIFDNLDLSISEGEKIGLVGINGTGKSTLLKVIGGIDDDFTANVMHPNQYRIRYSSQKQDLNEDMTVFDAVLSSDTTTLRIIKQYEQAVQAYADDQSDKLFKRMMDAQDAMDQHDAWDYNAEIKTILSKLGIHDTTKYIKELSGGQQKRVVLAKTLIEQPDLLLLDEPTNHLDFESISWLINYVKQYPHTVLFVTHDRYFLNEVSTRIIELNRGKLASYPGNYESYIEMRAEREVTLQKQQQKQRALYKEELAWMRAGAKARTTKQQARINRFNDLENEVNQQYKDDKGELNLAYSRLGKQVFELEDLSKAINDKVLFEHLTEIIQKGERIGVVGPNGAGKTTLLNILSGEDQQFEGKLKTGQTVKVAYFKQTDETLDRDIRMIDYLREENEIAKEKDGTSVSITQLLERFLFPSATHGKKVYKLSGGEQKRLYLLRLLVHQPNVLLLDEPTNDLDTETLTILEDYIHTFGGTVITVSHDRYFLNKVAQSYWFIHDGQMEKIIGTFEDYESYKKSLDKNKSTLKQQSKSSTTVRKKNGLSYKEKLEYEQLMKRIEQAEVRMEEIDVLMIEASADYGKIKELNEEKEQLEIQYDLDITRWSELEEIKEQQ
>NC_002951.2|WP_000098285.1|798689_800630_+|polyglycerol-phosphate-lipoteichoic-acid-synthase-LtaS
MSSQKKKISLFAFFLLTVITITLKTYFSYYVDFSLGVKGLVQNLILLMNPYSLVALVLSVFLFFKGKKAFWFMFIGGFLLTFLLYANVVYFRFFSDFLTFSTLNQVGNVESMGGAVSASFKWYDFVYFIDTLVYLFILIFKTKWLDTKAFSKKFVPVVMAASVALFFLNLAFAETDRPELLTRTFDHKYLVKYLGPYNFTVYDGVKTIENNQQKALASEDDLTKVLNYTKQRQTEPNPEYYGVAKKKNIIKIHLESFQTFLINKKVNGKEVTPFLNKLSSGKEQFTYFPNFFHQTGQGKTSDSEFTMDNSLYGLPQGSAFSLKGDNTYQSLPAILDQKQGYKSDVMHGDYKTFWNRDQVYKHFGIDKFYDATYYDMSDKNVVNLGLKDKIFFKDSANYQAKMKSPFYSHLITLTNHYPFTLDEKDATIEKSNTGDATVDGYIQTARYLDEALEEYINDLKKKGLYDNSVIMIYGDHYGISENHNNAMEKLLGEKITPAKFTDLNRTGFWIKIPGKSGGINNEYAGQVDVMPTILHLAGIDTKNYLMFGTDLFSKGHNQVVPFRNGDFITKDYKYVNGKIYSNKNNELITTQPADFEKNKKQVEKDLEMSDNVLNGDLFRFYKNPDFKKVNPSKYKYETGPKANSKK
>NC_002951.2|WP_000022323.1|797211_798216_+|biotin-dependent-carboxyltransferase-family-protein
MSIIIEKSGLFSSFQDFGRRGYEHDGVIPCGALDTLAHEIANRLVANDKNEATLEMTNKMATIRFTEPTLIALAGGNVKAYTEHMTISPYKLYLLDKGDVLKFRETSYTSRVYLAVGGGFELDAWLGSNSTDFNVKIGGFKGRTLQDGDEIKLKRDYTARHHKLFENLAHTKQTDWGIDGYALSFNYMSDVFHVVKNKGTEDFKEDAIQRFVKHDYKVTSKANRMGMMLEGEKIKAFYEDMPPYQTVKKGTIQIKRDGTPIILLNDHYTLGSYPQIGTIASYHLTKLAQKPQGSRLKFQFIDILTAEKNLVKYSNWLNQLFHGIEYRMQLEMMK
>NC_002951.2|WP_000708692.1|796517_797228_+|allophanate-hydrolase-subunit-1
MKIYSQGDQAIVVAIEKEVSKSLTEDLLTLRSYLIEQNYPFIIEIVPSESDMMIVYDARDMIKHHNIQSPFLYMKALIESIHLNIKHDFNQQDLIEIPIVYGSKYGPDLESLLKHYKIKLETFIELHSKAQYFVSMMGYSPGFPYLTGLNKKLYINHTSKQKKFIPAGSVVLEGKKCGIVTTDTINDWLVIGYTPLSLFNPKESDFARLKLGDNIKFRPINENELEVGAFKDVNHN
>NC_002951.2|WP_001790169.1|796223_796430_+|hypothetical-protein
MIIVYIVLLLILVYVNYRLVNRLLSENRIYVVRLIATITTVISFILVYALIHELMPFVVRAMDLMYHQ
>NC_002951.2|WP_000429014.1|810153_811071_-|diacylglycerol-kinase-family-lipid-kinase
MENKYTHGVLFYHEHSGLKNINQGIGEVTTALSSICKHLSIQLSENEGDIIKYCQEIKTKNYAKDVDILFILGGDGTVNELINGVMTHDLQLPIGILPGGTFNDFTKTLNIAPNHKQASEQMISAQVGTYDVIKINNQYALNFVGLGLIVQNAENVQDGSKDIFGKLSYIGSTVKTLLNPTQFNYQLSIDDKTYSGETTMILTANGPFIGGSRIPLTDLSPQDGELNTFIFNEQSFSILNDIFKKRDSMNWNEITQGIEHIPGKKISLTTDPAMKVDIDGEISLETPIDIEVIPNAIQLLTVNDL
>NC_002951.2|WP_001790641.1|811161_811263_+|hypothetical-protein
MVINEIDFYRVGRENIVIAVYNEHIKFLFILIS
>NC_002951.2|WP_000193751.1|811340_812846_-|peptide-MFS-transporter
MTQQNSHGNQIQDIPQTGFFGHPRGLGVLFFVEFWERFSYYGMRALLIFYMYFAVTDNGLGIDKTTAMSIMSVYGSLIYMTSIPGGWIADRITGTRGATLLGAVFIIIGHICLSLPFALIGLFTSMFFIIIGSGLMKPNISNIVGRLYPENDRRMDAGFVIFYMSVNMGALLSPIILQHFVNVKNFHGGFLIAAVGMALGLVWYVLFNRKNLGSVGMKPTNPLTPAEKKKYGLIIGSVVLAIVLIIVIGALTNSLSFNLVSNTVLVLGIALPIIYFTLIIRSKDVTDTERSRVKAFIPLFILGMVFWAIQEQGSNVLNIYGIEHSDMKLNLFGWKTNFGEAIFQSINPLFILLLAPIISLLWQKLGTKQPSLPVKFAIGTFLAGASYILIGIVGYASGSSNFSVNWVILSYIICVIGELCLSPTGNSAAVKLAPKAFNAQMMSIWYLTNASAQAINGTLVKLIEPLGQTNYFIFLGVVAIIVTTIVLAFSPLIIKAMKGIR
>NC_002951.2|WP_000930014.1|813186_813687_-|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF
MAHGRQQDELQDITLLGNQDNTYNFDYRPDVLESFDNKHQGRDYFVKFNCPEFTSLCPITGQPDFATIYISYIPNVKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPHYIEVWGKFTPRGGISIDPYTNYGRPNSKYEKMAEHRLMNHDLYPEKIDNR
>NC_002951.2|WP_001068497.1|813706_814573_-|DMT-family-transporter
MNPKVKGIIAILISAIGFSFMSVFFRLAGDLPVFQKSLARNLVAMFIPLFFIYKYHQPMFGRLSSQPLLITRSTLGLIGVLLNIYAIDHMVLSDADSLMKLNPFWTILLSIVFLHEKVRKYQITAMIIAILGMLLIVKPEFSSSMIPSLAGLFSGIFAASAYTCVRALSTREAPYTIVFYFSLFSVIVLIPFTAYTYEPMSQMQILYLLGAGLAAAVGQIGVTLAYSFAAAKDISIFTYASIIFTAILGFILFGESPDFYATLGYVVIIGASYYMFEKARRDAKIIKK
>NC_002951.2|WP_000692521.1|815373_815772_+|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI
MKIIYFSFTGNVRRFIKRTELENTLEITAENCMEPVHEPFIIVTGTIGFGEVPEPVQSFLEVNHQYIRGVAASGNRNWGLNFAKAGRTISEEYNVPLLMKFELHGKNKDVIEFKNKVGNFNENHGREKVQSY
>NC_002951.2|WP_000855505.1|815734_817840_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha
MKTMEEKKYNHIELNNEVTKRREDGFFSLEKDQEALVAYLEEVKDKTIFFDTEIERLRYLVDNDFYFNVFDIYSEADLIEITDYAKSIPFNFASYMSASKFFKDYALKTNDKSQYLEDYNQHVAIVALYLANGNKAQAKQFISAMVEQRYQPATPTFLNAGRARRGELVSCFLLEVDDSLNSINFIDSTAKQLSKIGGGVAINLSKLRARGEAIKGIKGVAKGVLPIAKSLEGGFSYADQLGQRPGAGAVYLNIFHYDVEEFLDTKKVNADEDLRLSTISTGLIVPSKFFDLAKEGKDFYMFAPHTVKEEYGVTLDDIDLEKYYDDMVANPNVEKKKKNAREMLNLIAQTQLQSGYPYLMFKDNANRVHPNSNIGQIKMSNLCTEIFQLQETSIINDYGIEDEIKRDISCNLGSLNIVNVMESGKFRDSVHSGMDALTVVSDVANIQNAPGVRKANSELHSVGLGVMNLHGYLAKNKIGYESEEAKDFANIFFMMMNFYSIERSMEIAKERGIKYQDFEKSDYANGKYFEFYTTQEFEPQFEKVRELFDGMAIPTSEDWKKLQQDVEQYGLYHAYRLAIAPTQSISYVQNATSSVMPIVDQIERRTYGNAETFYPMPFLSPQTMWYYKSAFNTDQMKLIDLIATIQTHIDQGISTILYVNSEISTRELARLYVYAHYKGLKSLYYTRNKLLSVEECTSCSI
>NC_002951.2|WP_000562498.1|817957_818929_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta
MIAVNWNTQEDMTNMFWRQNISQMWVETEFKVSKDIASWKTLSEAEQDTFKKALAGLTGLDTHQADDGMPLVMLHTTDLRKKAVYSFMAMMEQIHAKSYSHIFTTLLPSSETNYLLDEWVLEEPHLKYKSDKIVANYHKLWGKEASIYDQYMARVTSVFLETFLFFSGFYYPLYLAGQGKMTTSGEIIRKILLDESIHGVFTGLDAQHLRNELSESEKQKADQEMYKLLNDLYLNEESYTKMLYDDLGITEDVLNYVKYNGNKALSNLGFEPYFEEREFNPIIENALDTTTKNHDFFSVKGDGYVLALNVEALQDDDFVFDNK
>NC_002951.2|WP_000499195.1|819442_819598_+|hypothetical-protein
MFYFTLSKQNTHSEKLNFSLIANINKIDTKLFERLLKLWSKNATINEKYYQ
>NC_002951.2|WP_000876318.1|819636_820608_+|ABC-transporter-permease
MKYLLKGNILLLLLILLTIISLFIGVSELSIKDLLHLTESQRNILFSSRIPRTMSILIAGSSLALAGLIMQQMMQNKFVSPTTAGTMEWAKLGILIALLFFPTGHILLKLVFAVICSICGTFLFVKIIDFIKVKDVIFVPLLGIMMGGIVASFTTFISLRTNAVQSIGNWLNGNFAIITSGRYEILYLSIPLLALTYLFANHFTIVGMGKDFTNNLGLSYEKLINIALFITATITALVVVTVGTLPFLGLVIPNIISIYRGDHLKNAIPHTMMLGAIFVLFSDIVGRIVVYPYEINIGLTIGVFGTIIFLILLMKGRKNYAQQ

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Crispr_ID: NC_002951_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002951_4

850675-850755

Unclear

Consensus_repeat	Method
TTCTTTATGTTGGGGCCCCGCCAACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_002951_4

>merge|NC_002951|4|850675-850755|CRISPRCasFinder
TTCTTTATGTTGGGGCCCCGCCAACTTGCATTGTTTGTAGAATTTCTTTTCGAAATTCTTTATGTTGGGGCCCCGCCAACT

>NC_002951|4|4|850675-850755|CRISPRCasFinder
TTCTTTATGTTGGGGCCCCGCCAACT	TGCATTGTTTGTAGAATTTCTTTTCGAAA
TTCTTTATGTTGGGGCCCCGCCAACT

Protein	Signature genes	Signature genes Name	Protein_function
NC_002951.2\|WP_001790092.1\|841588_841693_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000816295.1\|860780_861683_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NC_002951.2\|WP_000006551.1\|858433_859378_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NC_002951.2\|WP_000506531.1\|839015_841547_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NC_002951.2\|WP_000617732.1\|838029_838602_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NC_002951.2\|WP_001224793.1\|852776_853262_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NC_002951.2\|WP_001790093.1\|843125_843233_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000958224.1\|850991_851924_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NC_002951.2\|WP_000057548.1\|853269_854709_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NC_002951.2\|WP_000513308.1\|851929_852769_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NC_002951.2\|WP_000538141.1\|844393_845044_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NC_002951.2\|WP_000662681.1\|847538_850385_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_002951.2\|WP_000369722.1\|856420_857332_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NC_002951.2\|WP_001049165.1\|859950_860538_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NC_002951.2\|WP_000749380.1\|843380_844220_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NC_002951.2\|WP_000229253.1\|845545_847531_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_002951.2\|WP_000638419.1\|845040_845277_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234
NC_002951.2\|WP_010956549.1\|841861_842972_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NC_002951.2\|WP_000134963.1\|854775_855711_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NC_002951.2\|WP_001248939.1\|857328_858324_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689

Protein	Function_ID	Function_description	E-value
NC_002951.2\|WP_000816295.1\|860780_861683_-\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	4.94096e-153
NC_002951.2\|WP_000006551.1\|858433_859378_+\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
NC_002951.2\|WP_000506531.1\|839015_841547_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NC_002951.2\|WP_000749380.1\|843380_844220_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	2.23913e-42
NC_002951.2\|WP_000229253.1\|845545_847531_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_002951.2\|WP_000617732.1\|838029_838602_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.54305e-37
NC_002951.2\|WP_000662681.1\|847538_850385_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_002951.2\|WP_000057548.1\|853269_854709_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	4.50708e-06
NC_002951.2\|WP_000513308.1\|851929_852769_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.39921e-119
NC_002951.2\|WP_000538141.1\|844393_845044_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NC_002951.2\|WP_000958224.1\|850991_851924_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NC_002951.2\|WP_000369722.1\|856420_857332_+\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
NC_002951.2\|WP_001049165.1\|859950_860538_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NC_002951.2\|WP_001224793.1\|852776_853262_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
NC_002951.2\|WP_000638419.1\|845040_845277_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
NC_002951.2\|WP_010956549.1\|841861_842972_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_002951.2\|WP_000134963.1\|854775_855711_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
NC_002951.2\|WP_001248939.1\|857328_858324_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172

>NC_002951.2|WP_000662681.1|847538_850385_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>NC_002951.2|WP_000229253.1|845545_847531_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NC_002951.2|WP_000638419.1|845040_845277_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NC_002951.2|WP_000538141.1|844393_845044_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NC_002951.2|WP_000749380.1|843380_844220_+|CHAP-domain-containing-protein
MKKSLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKSPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVTKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>NC_002951.2|WP_001790093.1|843125_843233_+|hypothetical-protein
MCLLKQHMQCAFSNITYGDFQGIELIIENVLNYMV
>NC_002951.2|WP_010956549.1|841861_842972_+|peptide-chain-release-factor-2
MELSEIKRNIDKYNQDLTQIRGSLDLENKETNIQEYEEMMAEPNFWDNQTKAQDIIDKNNALKAIVNGYKTLQAEVDDMDATWDLLQEEFDEEMKEDLEQEVINFKAKVDEYELQLLLDGPHDANNAILELHPGAGGTESQDWANMLFRMYQRYCEKKGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPDFNNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPSGIVVNNQNERSQIKNREAAMKMLKSKLYQLKLEEQAREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGDIGPFIESYLRQTMSHD
>NC_002951.2|WP_001790092.1|841588_841693_+|hypothetical-protein
MLWEESFYFTSVKYFKKCEEVVKRCYVLSFKKSV
>NC_002951.2|WP_000506531.1|839015_841547_+|preprotein-translocase-subunit-SecA
MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQNDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPTYLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITYSTNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKQDEDYKYDEKTKAVHLTEQGADKAERMFKVENLYDVQNVDVISHINTALRAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMASITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGKFDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGAGQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGDSRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARKRILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQPFIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILLRSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILKSVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNCHGK
>NC_002951.2|WP_000617732.1|838029_838602_+|ribosome-associated-translation-inhibitor-RaiA
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFIDRETDGTSIVYRRKDGKYGLIQTSEQ
>NC_002951.2|WP_000958224.1|850991_851924_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NC_002951.2|WP_000513308.1|851929_852769_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGSVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>NC_002951.2|WP_001224793.1|852776_853262_+|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NC_002951.2|WP_000057548.1|853269_854709_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDMEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDRAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVSENDVMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NC_002951.2|WP_000134963.1|854775_855711_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NC_002951.2|WP_000369722.1|856420_857332_+|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NC_002951.2|WP_001248939.1|857328_858324_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NC_002951.2|WP_000006551.1|858433_859378_+|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>NC_002951.2|WP_001049165.1|859950_860538_+|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NC_002951.2|WP_000816295.1|860780_861683_-|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKALFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGIILSNEGGALQTMKLPYEYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE

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Crispr_ID: NC_002951_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002951_5

899233-899314

Orphan

Consensus_repeat	Method
CCCCAACTTGCATTGTCTGTAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_002951_5

>merge|NC_002951|5|899233-899314|CRISPRCasFinder
CCCCAACTTGCATTGTCTGTAGAAATTGGGAATCCAATTTCTCTTTGTTGGGGCCCATCCCCAACTTGCATTGCCTGTAGAA

>NC_002951|5|5|899233-899314|CRISPRCasFinder
CCCCAACTTGCATTGTCTGTAGAA	ATTGGGAATCCAATTTCTCTTTGTTGGGGCCCAT
CCCCAACTTGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_002951.2\|WP_000932216.1\|898250_899129_+\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|226395
NC_002951.2\|WP_001228759.1\|906349_906781_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000974460.1\|894655_895078_-\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649
NC_002951.2\|WP_000266157.1\|903490_904711_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NC_002951.2\|WP_000150017.1\|895225_895942_+\|type-I-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|184156
NC_002951.2\|WP_000422909.1\|896024_896564_+\|nitroreductase	unknown	unknown	gnl\|CDD\|380312
NC_002951.2\|WP_000290485.1\|897691_898072_+\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NC_002951.2\|WP_000520233.1\|901813_902509_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NC_002951.2\|WP_000733775.1\|904799_905528_-\|staphylococcal-enterotoxin-type-K	unknown	unknown	gnl\|CDD\|280949
NC_002951.2\|WP_000571218.1\|900795_901821_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224058
NC_002951.2\|WP_000589549.1\|897177_897534_+\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239334
NC_002951.2\|WP_000732326.1\|902526_903348_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NC_002951.2\|WP_001065801.1\|900249_900546_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_002951.2\|WP_000569886.1\|893762_894257_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|372596
NC_002951.2\|WP_001190695.1\|896713_897034_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_002951.2\|WP_000281657.1\|906797_907256_-\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|368753
NC_002951.2\|WP_001033316.1\|905551_906280_-\|staphylococcal-enterotoxin-type-Q	unknown	unknown	gnl\|CDD\|280949
NC_002951.2\|WP_001140693.1\|892336_892918_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NC_002951.2\|WP_000255561.1\|892990_893608_-\|amino-acid-transporter	unknown	unknown	gnl\|CDD\|224198
NC_002951.2\|WP_001018962.1\|899870_900257_+\|topiosmerase	unknown	unknown	gnl\|CDD\|224572

Protein	Function_ID	Function_description	E-value
NC_002951.2\|WP_000932216.1\|898250_899129_+\|DUF1963-domain-containing-protein	gnl\|CDD\|226395	COG3878, COG3878, Uncharacterized protein conserved in bacteria [Function unknown].	1.16579e-75
NC_002951.2\|WP_000974460.1\|894655_895078_-\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	5.58225e-61
NC_002951.2\|WP_000266157.1\|903490_904711_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	6.11443e-38
NC_002951.2\|WP_000150017.1\|895225_895942_+\|type-I-3-dehydroquinate-dehydratase	gnl\|CDD\|184156	PRK13575, PRK13575, type I 3-dehydroquinate dehydratase.	1.26721e-148
NC_002951.2\|WP_000422909.1\|896024_896564_+\|nitroreductase	gnl\|CDD\|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	1.47647e-49
NC_002951.2\|WP_000290485.1\|897691_898072_+\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	2.81086e-68
NC_002951.2\|WP_000520233.1\|901813_902509_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	9.67625e-100
NC_002951.2\|WP_000733775.1\|904799_905528_-\|staphylococcal-enterotoxin-type-K	gnl\|CDD\|280949	pfam02876, Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain.	1.08384e-24
NC_002951.2\|WP_000571218.1\|900795_901821_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	3.37873e-170
NC_002951.2\|WP_000589549.1\|897177_897534_+\|arsenate-reductase-family-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	1.06191e-56
NC_002951.2\|WP_000732326.1\|902526_903348_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	2.15951e-112
NC_002951.2\|WP_001065801.1\|900249_900546_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	7.01368e-14
NC_002951.2\|WP_000569886.1\|893762_894257_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|372596	pfam13420, Acetyltransf_4, Acetyltransferase (GNAT) domain.	3.99356e-47
NC_002951.2\|WP_001190695.1\|896713_897034_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.70086e-24
NC_002951.2\|WP_000281657.1\|906797_907256_-\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	0.00011929
NC_002951.2\|WP_001033316.1\|905551_906280_-\|staphylococcal-enterotoxin-type-Q	gnl\|CDD\|280949	pfam02876, Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain.	1.13367e-27
NC_002951.2\|WP_001140693.1\|892336_892918_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	5.2875e-48
NC_002951.2\|WP_000255561.1\|892990_893608_-\|amino-acid-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	9.12336e-62
NC_002951.2\|WP_001018962.1\|899870_900257_+\|topiosmerase	gnl\|CDD\|224572	COG1658, COG1658, Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair].	2.45102e-36

>NC_002951.2|WP_000932216.1|898250_899129_+|DUF1963-domain-containing-protein
MLNIQDVSHLSKKEQKAYNRFVESVENGNLPVLPCIEMDLKEMQEETLNQSKIGGMPFLKSFKDIPLDENNVPMVLLAQINLDDLPEQQELFPVKEGILQFWISSEDQMYGMSENLKGNNINSRLVYIKEPITDLSLENIQAHLKSLDADNEDIPFSGAFSIEFRLSKQTITCTDYKYDEDVLALWNKVNPSFALKSMFGGYDELMEPVCNTFTAKEPFNQLGGYPYFDQIDPRTNDQELKMYDRVLLQIDSTRDGNSSIIWGDLGIANILVKSTDLEAMKFDDYMYSWDCS
>NC_002951.2|WP_000290485.1|897691_898072_+|glycine-cleavage-system-protein-GcvH
MAVPNELKYSKEHEWVKVEGNVAIIGITEYAQSELGDIVFVELPETDDEINEGDTFGSVESVKTVSELYAPISGKVVEVNEELEDSPEFVNESPYEKAWMVKVEISDESQIEALLTAEKYSEMIGE
>NC_002951.2|WP_000589549.1|897177_897534_+|arsenate-reductase-family-protein
MIKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTGVEINKLFNTHGAKYRELDLKNKLQTLSDDEKLELLSSDGMLVKRPLAVMGDKITLGFKEDQYKETWLA
>NC_002951.2|WP_001190695.1|896713_897034_-|thioredoxin-family-protein
MQSIKSNESFKSVINSDTPVIVKFEAGWCPDCRAMDLWIDPIVEQYNDYQWYTVNRDELEDVVVENEVMGIPSLLVFKNGDKIAHLHSANAKSPEQVESFLAETFK
>NC_002951.2|WP_000422909.1|896024_896564_+|nitroreductase
MELQQAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFAFPNELDKQQCHYDAVTKLGGMLLLILKTDPRQRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYLTDLEGDMPKAPRKNRNLITLY
>NC_002951.2|WP_000150017.1|895225_895942_+|type-I-3-dehydroquinate-dehydratase
MTHVEVVATIAPQLSIEETLIQKINHRIDAIDVLELRIDQIENVTVDQVAEMITKLKVMQDSFKLLVTYRTKLQGGYGQFTNDSYLNLISDLANINGIDMIDIEWQADIDIEKHQRIITHLQQYNKEVVISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMSTFSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGVPQAPGQIDVTDLKAQVTLY
>NC_002951.2|WP_000974460.1|894655_895078_-|organic-hydroperoxide-resistance-protein
MAIHYETKATNVGGRKGHVYTDDRALDIDIVPPAQADGKATNPEQLFAAGYASCFNGAFDLILKQNKVRDAHPEVTLTVRLEDDSDSESPKLSVSIDATIKNVISQEEAEKYLQMAHEFCPYSKATQGNINVDLNVNVVD
>NC_002951.2|WP_000569886.1|893762_894257_-|GNAT-family-N-acetyltransferase
MIEIKTLTNNDFNEYKRLVSTVNEEFTQDSHYSQTMTDTLIHDILNQGSPKCIVFGCYENETLIATAALEQIRYVGKEHKSLIKYNFVTNNDKSINSELINFIINYARQNNYEYLLTSIVSNNIGAKVFYSALGFDILGFEKNAIKIGNTYFDEHWLFYDLINK
>NC_002951.2|WP_000255561.1|892990_893608_-|amino-acid-transporter
MVTAIIHGFILAIGLILPLGAQNVFIFNQGANQPKYRYVLPAIITAGLSDSLLIIIAVVGVSIIIMSLPVLQAIIYIVGLIFLMYMAWTIWHDKPSTDGETQIMSPMKQVSFALSVSLLNPHAILDTIGVIGSSAALYSGSNKIAFTIACISVSWLWFFLLAILGKMVGSIDKTGKLLTIINKISSIIIIIVALMILQKLIQLLF
>NC_002951.2|WP_001140693.1|892336_892918_+|histidine-phosphatase-family-protein
MAKTLYLMRHGQTLFNFKGLIQGFGDSPLTELGIAQAQKARSYYETKGINFDLYASSTQERASDTLENVAPNQSYQRFKGLKEWHFGIFEGESVYLFDNLYKPEDLFGDRIVPFKGEARQQVEERIVKTLHDIMSQTKNNALVVSHGTIMGVFLRYCLKLDEALKHNIGNCNILKFEYDNGTFKFVELIDPNL
>NC_002951.2|WP_001018962.1|899870_900257_+|topiosmerase
MAIVNKVIIVEGKSDKKRVQQVIAEPVNIICTHGTMSIDKLDDMIESLYDKQVFVLADSDDEGDRIRNWFKRYLSESEHIFIDKTYCQVANCPKQYLAHVLSKHGFTCKKETPLLPNINNERLVLVNE
>NC_002951.2|WP_001065801.1|900249_900546_+|thioredoxin-family-protein
MNNSLDIKDVTTFYEEDKHLIFGYTPTCGTCKVSERMLDIANEILQLPLLKIDLNFYPQFCKDMQIMSTPILLLMNKDKEVKRIYAFKSVTDLLENLK
>NC_002951.2|WP_000571218.1|900795_901821_+|methionine-ABC-transporter-ATP-binding-protein
MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIVLITHEMHVIRRICDEVAVMESGKVIEQGPVTQVFENPQHTVTKRFVKDDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSVDFGKFEKELIERQVKMEVLRHG
>NC_002951.2|WP_000520233.1|901813_902509_+|ABC-transporter-permease
MGKSFSEIINEMITMPNIQWPEVWTAIVETLYMTVVSTIFAFILGLILGVLLFLSAKGKSIGARLFYSIVSFIVNLFRAIPFIILILLLIPFTSLILGTISGPTGALPALIIGAAPFYARLVEIAFKEIDKGVIEAAWSMGANTWTVIRKVLLPEAMPALVSGITVTAIALVGSTAVAGVIGAGGLGNLAYLTGFTRNQNDVILVSTVFILIIVFIIQFIGDWLTNKLDKR
>NC_002951.2|WP_000732326.1|902526_903348_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKLFGLILVLTFAVVLAACGNGNKSGSDDKKITVGASPAPHAEILEKAKPLLEKKGYELDIKTINDYTTPNKLLDKGEIDANYFQHTPYLNTEKKDKGYKIVSAGDVHLEPMAVYSKKYKSLKELPKGATVYVSNNPAEQGRFLKFFVDAGLIKIKKGVKIEDAKFSDITENKKDIKFNNKQSAEFLPKIYQNEDADAVIINSNFAIEQKLNPKKDSIAVESAKDNPYANLIAVKEGHQDDKKIKALIEVLQSKDIQDFINEKYNGAVIPAK
>NC_002951.2|WP_000266157.1|903490_904711_-|site-specific-integrase
MWLEKFKNKNKETKYRYYEKYKDPLTAKWRRVSVVLNKNGKQSQKEAQRLLNERIEAKLNDKTPTTLKSLTFHVACDEWFQSYIKTSGSKRTTIKTKLSKLNTLKKFVDEDILINKITLSYAQQVFDEMDNKGYVYQVNKDALSIFKNVFEYTRRIYKLQDLEFLKDITLNKRIKSYDEVKAKRNKYLELNEIQSIIKDINTKAQKMHSGIHKRFYLFVALMTEFQALNGMRIGEMLAIQNEDIDFDNKSLNINGTIHWFHDESGGFGVKDTTKTESSYRTIGLSSRSCEILKKAILENKKDSKWNDGYLNRNFVFTNHKGNPMQTERFNKILREAAKDVGIDKEVSSHILRHSHISLLSQQGVSLKAIMDRVGHSDHRTTLSIYSHVTEQMDKDMMNKLEQVKLG
>NC_002951.2|WP_000733775.1|904799_905528_-|staphylococcal-enterotoxin-type-K
MKKLISILLINIIILGVSNSASAQGDIGIDNLRNFYTKKDFVDLKDVKDNDTPIANQLQFSNESYDLISESKDFNKFSNFKGKKLDVFGISYNGQCNTKYIYGGVTATNEYLDKSRNIPINIWINGNHKTISTNKVSTNKKFVTAQEIDVKLRKYLQEEYNIYGHNGTKKGEEYGHKSKFYSGFNIGKVTFHLNNNDTFSYDLFYTGDDGLPKSFLKIYEDNKTVESEKFHLDVDISYKETI
>NC_002951.2|WP_001033316.1|905551_906280_-|staphylococcal-enterotoxin-type-Q
MNKIFRILTVSLFFFTFLIKNNLAYADVGVINLRNFYANYEPEKLQGVSSGNFSTSHQLEYIDGKYTLYSQFHNEYEAKRLKDHKVDIFGISYSGLCNTKYMYGGITLANQNLDKPRNIPINLWVNGKQNTISTDKVSTQKKEVTAQEIDIKLRKYLQNEYNIYGFNKTKKGQEYGYQSKFNSGFNKGKITFHLNNEPSFTYDLFYTGTGQAESFLKIYDDNKTIDTENFHLDVEISYEKTE
>NC_002951.2|WP_001228759.1|906349_906781_-|hypothetical-protein
MRKLLGLALASTLILGACGSNDGDKKEESKSYTTNDIVKGFKDNKLNVINEKEMTREDFGLAPMKTDEAKMFVVQDDKNARVMKFKNSDDLKQTKKYYDELGKESAAFYSHTHSKGKFLIQMNGDIDDATFNKYKNSMDKTLK
>NC_002951.2|WP_000281657.1|906797_907256_-|ImmA/IrrE-family-metallo-endopeptidase
MYLYEKMVIENKEIPIDDGKSLGNFEGLYDNGVILINKNLSERRKAEVLYEELAHHKLTYGNILDQSKFNNRKFENYARRHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

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Crispr_ID: NC_002951_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002951_6

964023-964305

Orphan

Consensus_repeat	Method
AAAGNCAGCTNNNNANANNNTGCAAGTTGG	CRT

4 spacers

The CRISPR arrays of NC_002951_6

>merge|NC_002951|6|964023-964305|CRT
AAAGTCAGCTTACAATAGTGTGCAAGTTGGCGGGGCCCCAACACAGAGGCTGGCGGAAAGTCAGCTTACAATAGTGTGCAAGTTGGGGTGGAGCCCCGACACAGAGAAATTAGCTCCTCAATTTCTACAGACAATGCAAGTTGGCGGGGCCCCAACACAGAAGCTGGCGAAAAGTCAGCTTACAATAGTGTGCAAGTTGGGGTGGGACGACGAAATAAATTTTGCGAAAATATCATTTCTGTCCCACTCCCAAAAAGACAGCAGTAGGATAATTTCAATTTGG

>NC_002951|6|1|964023-964305|CRT
AAAGTCAGCTTACAATAGTGTGCAAGTTGG	CGGGGCCCCAACACAGAGGCTGGCGG
AAAGTCAGCTTACAATAGTGTGCAAGTTGG	GGTGGAGCCCCGACACAGAGAAATTAGC
TCCTCAATTTCTACAGACAATGCAAGTTGG	CGGGGCCCCAACACAGAAGCTGGCGA
AAAGTCAGCTTACAATAGTGTGCAAGTTGG	GGTGGGACGACGAAATAAATTTTGCGAAAATATCATTTCTGTCCCACTCCCAA
AAAGACAGCAGTAGGATAATTTCAATTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_002951.2\|WP_000167314.1\|961328_962519_+\|ornithine--oxo-acid-transaminase	unknown	unknown	gnl\|CDD\|179736
NC_002951.2\|WP_000758215.1\|970706_971231_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_002951.2\|WP_000838037.1\|959893_961021_+\|NADH-dependent-flavin-oxidoreductase	unknown	unknown	gnl\|CDD\|240086
NC_002951.2\|WP_000148855.1\|968470_969802_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|184504
NC_002951.2\|WP_001067294.1\|959154_959532_+\|S1-RNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224023
NC_002951.2\|WP_000670752.1\|979277_980180_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NC_002951.2\|WP_000185319.1\|964374_965304_-\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176543
NC_002951.2\|WP_000711486.1\|971246_971822_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_002951.2\|WP_000054609.1\|955162_957568_-\|Na+/H+-antiporter-Mnh1-subunit-A	unknown	unknown	gnl\|CDD\|237155
NC_002951.2\|WP_000007967.1\|970126_970702_+\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NC_002951.2\|WP_000402803.1\|954400_954742_-\|Na+/H+-antiporter-Mnh1-subunit-C	unknown	unknown	gnl\|CDD\|181497
NC_002951.2\|WP_000154930.1\|975458_979112_+\|helicase-exonuclease-AddAB-subunit-AddA	unknown	unknown	gnl\|CDD\|274299
NC_002951.2\|WP_001081626.1\|954741_955170_-\|Na+/H+-antiporter-Mnh1-subunit-B	unknown	unknown	gnl\|CDD\|183602
NC_002951.2\|WP_000035060.1\|958145_958739_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|238908
NC_002951.2\|WP_000138487.1\|962627_963872_+\|Glu/Leu/Phe/Val-dehydrogenase	unknown	unknown	gnl\|CDD\|223411
NC_002951.2\|WP_000660045.1\|966914_968120_-\|argininosuccinate-synthase	unknown	unknown	gnl\|CDD\|234785
NC_002951.2\|WP_000573071.1\|952911_954408_-\|Na+/H+-antiporter-Mnh1-subunit-D	unknown	unknown	gnl\|CDD\|181085
NC_002951.2\|WP_000781156.1\|957698_958082_-\|kinase-associated-lipoprotein-B	unknown	unknown	gnl\|CDD\|378054
NC_002951.2\|WP_000066053.1\|965545_966925_-\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NC_002951.2\|WP_000172345.1\|971981_975458_+\|helicase-exonuclease-AddAB-subunit-AddB	unknown	unknown	gnl\|CDD\|213736

Protein	Function_ID	Function_description	E-value
NC_002951.2\|WP_000167314.1\|961328_962519_+\|ornithine--oxo-acid-transaminase	gnl\|CDD\|179736	PRK04073, rocD, ornithine--oxo-acid transaminase; Provisional.	0
NC_002951.2\|WP_000758215.1\|970706_971231_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	2.63848e-48
NC_002951.2\|WP_000838037.1\|959893_961021_+\|NADH-dependent-flavin-oxidoreductase	gnl\|CDD\|240086	cd04735, OYE_like_4_FMN, Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	0
NC_002951.2\|WP_000148855.1\|968470_969802_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|184504	PRK14097, pgi, glucose-6-phosphate isomerase; Provisional.	0
NC_002951.2\|WP_001067294.1\|959154_959532_+\|S1-RNA-binding-domain-containing-protein	gnl\|CDD\|224023	COG1098, VacB, Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis].	3.22125e-44
NC_002951.2\|WP_000670752.1\|979277_980180_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.0042e-87
NC_002951.2\|WP_000185319.1\|964374_965304_-\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176543	cd08601, GDPD_SaGlpQ_like, Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized glycerophosphodiester phosphodiesterase (GP-GDE, EC 3.1.4.46) from Staphylococcus aureus, Bacillus subtilis and similar proteins. Members in this family show very high sequence similarity to Escherichia coli periplasmic phosphodiesterase GlpQ, which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	5.11302e-151
NC_002951.2\|WP_000711486.1\|971246_971822_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	4.05406e-53
NC_002951.2\|WP_000054609.1\|955162_957568_-\|Na+/H+-antiporter-Mnh1-subunit-A	gnl\|CDD\|237155	PRK12645, PRK12645, monovalent cation/H+ antiporter subunit A; Reviewed.	0
NC_002951.2\|WP_000007967.1\|970126_970702_+\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	1.01759e-40
NC_002951.2\|WP_000402803.1\|954400_954742_-\|Na+/H+-antiporter-Mnh1-subunit-C	gnl\|CDD\|181497	PRK08600, PRK08600, putative monovalent cation/H+ antiporter subunit C; Reviewed.	9.82501e-64
NC_002951.2\|WP_000154930.1\|975458_979112_+\|helicase-exonuclease-AddAB-subunit-AddA	gnl\|CDD\|274299	TIGR02785, ATP-dependent_helicase/nuclease_subunit_A, helicase-exonuclease AddAB, AddA subunit, Firmicutes type. AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_002951.2\|WP_001081626.1\|954741_955170_-\|Na+/H+-antiporter-Mnh1-subunit-B	gnl\|CDD\|183602	PRK12573, PRK12573, Na(+)/H(+) antiporter subunit B.	9.17513e-61
NC_002951.2\|WP_000035060.1\|958145_958739_+\|peptidylprolyl-isomerase	gnl\|CDD\|238908	cd01927, cyclophilin_WD40, cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the protein is not known.	6.93398e-65
NC_002951.2\|WP_000138487.1\|962627_963872_+\|Glu/Leu/Phe/Val-dehydrogenase	gnl\|CDD\|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	0
NC_002951.2\|WP_000660045.1\|966914_968120_-\|argininosuccinate-synthase	gnl\|CDD\|234785	PRK00509, PRK00509, argininosuccinate synthase; Provisional.	0
NC_002951.2\|WP_000573071.1\|952911_954408_-\|Na+/H+-antiporter-Mnh1-subunit-D	gnl\|CDD\|181085	PRK07691, PRK07691, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0
NC_002951.2\|WP_000781156.1\|957698_958082_-\|kinase-associated-lipoprotein-B	gnl\|CDD\|378054	pfam08810, KapB, Kinase associated protein B. This bacterial protein forms an anti-parallel beta sheet with an extending alpha helical region.	1.89892e-52
NC_002951.2\|WP_000066053.1\|965545_966925_-\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NC_002951.2\|WP_000172345.1\|971981_975458_+\|helicase-exonuclease-AddAB-subunit-AddB	gnl\|CDD\|213736	TIGR02773, ATP-dependent_helicase/deoxyribonuclease_subunit_B, helicase-exonuclease AddAB, AddB subunit. DNA repair is accomplished by several different systems in prokaryotes. Recombinational repair of double-stranded DNA breaks involves the RecBCD pathway in some lineages, and AddAB (also called RexAB) in other. The AddA protein is conserved between the firmicutes and the alphaproteobacteria, while the partner protein is not. Nevertheless, the partner is designated AddB in both systems. This model describes the AddB protein as found Bacillus subtilis and related species. Although the RexB protein of Streptococcus and Lactococcus is considered to be orthologous, functionally equivalent, and merely named differently, all members of this protein family have a P-loop nucleotide binding motif GxxGxGK[ST] at the N-terminus, unlike RexB proteins, and a CxxCxxxxxC motif at the C-terminus, both of which may be relevant to function. [DNA metabolism, DNA replication, recombination, and repair].	0

>NC_002951.2|WP_000138487.1|962627_963872_+|Glu/Leu/Phe/Val-dehydrogenase
MTENNNLVTSTQGIIKEALHKLGFDEGMYDLIKEPLRMLQVRIPVRMDDGTVKTFTGYRAQHNDAVGPTKGGVRFHPDVDEEEVKALSMWMTLKCGIVNLPYGGGKGGIVCDPRQMSIHEVERLSRGYVRAISQFVGPNKDIPAPDVFTNSQIMAWMMDEYSALDKFNSPGFITGKPIVLGGSHGRDRSTALGVVIAIEQAAKRRNMQIEGAKVVIQGFGNAGSFLAKFLYDLGAKIVGISDAYGALHDPNGLDIDYLLDRRDSFGTVTNLFEETISNKELFELDCDILVPAAISNQITEDNAHDIKASIVVEAANGPTTPEATRILTERGILLVPDVLASAGGVTVSYFEWVQNNQGYYWSEEEVNEKLREKLEAAFDTIYELSQNRKIDMRLAAYIIGIKRTAEAARYRGWA
>NC_002951.2|WP_000167314.1|961328_962519_+|ornithine--oxo-acid-transaminase
MTKSEKIIELTNHYGAHNYLPLPIVISEAEGVWVKDPEGNKYMDMLSAYSAVNQGHRHPKIIQALKDQADKVTLVSRAFHSDNLGEWYEKICKLAGKDKALPMNTGAEAVETALKAARRWAYDVKGIEPNKAEIIAFNGNFHGRTMAPVSLSSEAEYQRGYGPLLDGFRKVDFGDVDALKAAINENTAAVLVEPIQGEAGINIPPEGYLKAIRELCDEHNVLFIADEIQAGLGRSGKLFATDWDNVKPDVYILGKALGGGVFPISVVLADKEVLDVFTPGSHGSTFGGNPLACAASIAALDVIVDEDLPGRSLELGDYFKEQLKQIDHPSIKEVRGRGLFIGVELNESARPYCEALKEEGLLCKETHDTVIRFAPPLIITKEELDLALEKIRHVFQ
>NC_002951.2|WP_000838037.1|959893_961021_+|NADH-dependent-flavin-oxidoreductase
MKSKYEPLFDKVELPNGVELRNRFVLAPLTHISSNDDGTISDVELPYIEKRSQDVGITINAASNVSDVGKAFPGQPSIAHDSNIEGLKRLATAMKKNGAKALVQIHHGGAQALPELTPDGDVVAPSPISLKSFGQKQEHSAREMTNEEIEQAIKDFGEATRRAIEAGFDGVEIHGANHYLIHQFVSPYYNRRNDVWANQYKFPVAVIEEVLKAKEAYGNKDFIVGYRLSPEEAESPGITMEITEELVNKISHMPIDYIHVSMMDTHATTREGKYAGQERLPLIHKWINGRMPLIGIGSIFTADEALDAVENVGVDLVAIGRELLLDYQFVEKIKDGREDEIINYFDPEREDNHHLTPNLWHQFNEGFYPLPRKDK
>NC_002951.2|WP_001067294.1|959154_959532_+|S1-RNA-binding-domain-containing-protein
MNNYKIGQHIKVRVTGIQPYGAFVETPNHTEGLIHISEIMDDYVHNLKKFLSEGQIVKAKILSIDDEGKLNLSLKDNDYFKNYERKKEKQSVLDEIRETEKYGFQTLKERLPIWIKQSKRAIRND
>NC_002951.2|WP_000035060.1|958145_958739_+|peptidylprolyl-isomerase
MANYPQLNKEVQQGEIKVVMHTNKGDMTFKLFPNIAPKTVENFVTHAKNGYYDGITFHRVINDFMIQGGDPTATGMGGESIYGGAFEDEFSLNAFNLYGALSMANSGPNTNGSQFFIVQMKEVPQNMLSQLTDGGWPQPIVDAYGEKGGTPWLDQKHTVFGQIIDGETTLEDIANTKVGPQDKPLHDVVIESIDVEE
>NC_002951.2|WP_000781156.1|957698_958082_-|kinase-associated-lipoprotein-B
MKLYRFSHKTGSYGVTIVEENGDDVLVKVEQVIKHPKQGDLHNPTETEGVFFHDRKALSHFEKRYTKRSQLRDFNVDVLRYEDSLQQAITDLETKLKAQQTKHAEMSLASLARLKEDYSLQYKENFK
>NC_002951.2|WP_000054609.1|955162_957568_-|Na+/H+-antiporter-Mnh1-subunit-A
MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAILATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVIIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE
>NC_002951.2|WP_001081626.1|954741_955170_-|Na+/H+-antiporter-Mnh1-subunit-B
MNRQQNDLILQFAAVIIFFMVMVFGFSLFLAGHYTPGGGFVGGLLFASSLVIITIAFDIETMRKIFPLDFKILIGIGLVFCIATPIASWFLGKNFFTHVTFDIPLFILEPVHMTTAVFFDFGVLCAVVGTVMTIIISIGENE
>NC_002951.2|WP_000402803.1|954400_954742_-|Na+/H+-antiporter-Mnh1-subunit-C
MEIIMIFVSGILTAISVYLVLSKSLIRIVMGTTLLTHAANLFLITMGGLKHGTVPIYEANVKSYVDPIPQALILTAIVIAFATTAFFLVLAFRTYKELGTDNVESMKGVPEDD
>NC_002951.2|WP_000573071.1|952911_954408_-|Na+/H+-antiporter-Mnh1-subunit-D
MIESNMLVLTLVIPVITAILLVFIGKRPIIKRYVALGGTLLTLVAAIINLANVVKHGPIRVELGSWKAPYSIVFVLDIFSALLIITSIIITAIVILYSSQTIGIERERYYYYFSVLFMLIGIIGAFTTGDIFNLFVFFEVFLMSSYFLLVIGSTKIQLQETIKYVLVNVVSSSFFVMGVAILYSVVGTLNLADISNKLANLSAHDSGLVNIVFILFIFVFATKAGVFPMFVWLPSAYYAPPIPIIAFFGALLTKVGVYAIARTLSLFFSDNVSFSHYVILFLALLTIIFGCVGAVAYANIKKIILYNVMIAVGVILVGVAMMTESGMIGAIYYTLHDMLVKLALFLLIGIMIKITGTADLRQFGGLIKRYPVLGWSFFIAALSLAGIPPLSGFYGKFFIVQSTFERGFYLSGVIVLLSSLVVLYSVIRIFLQGFFGQPKGYDLNNKVDVKYLTTIAIVAVVITVLYGLSADYLYPMVKAGAETFYNPSTYVKAVLGGK
>NC_002951.2|WP_000185319.1|964374_965304_-|glycerophosphodiester-phosphodiesterase
MTNSSKSFTKFMAASAVFTMGFLSVPTAGAEQTNQIANKPQAIQWHTNLTNERFTTIAHRGASGYAPEHTFQAYDKSHNELKASYIEIDLQRTKDGHLVAMHDETVNRTTNGHGKVEDYTLDELKQLDAGSWFNKKYPKYARASYKNAKVPTLDEILERYGPNANYYIETKSPDVYPGMEEQLLASLKKHHLLNNNKLKNGHVMIQSFSDESLKKIHRQNKHVPLVKLVDKGELQQFNDQRLKEIRSYAIGLGPDYTDLTEQNTHHLKDLGFIVHPYTVNEKADMLRLNKYGVDGVFTNFADKYKEVIK
>NC_002951.2|WP_000066053.1|965545_966925_-|argininosuccinate-lyase
MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSASLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPGYTHLQRAQPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETLHNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNKDMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGHYLLDVPLATYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ
>NC_002951.2|WP_000660045.1|966914_968120_-|argininosuccinate-synthase
MKEKIVLAYSGGLDTSVAVQWLIDKGYDVVACCLDVGEGKDLDIVYKKALDMGAVECHIIDATKEFSDEYVSYAIKGNLMYENAYPLVSALSRPLIAKKLVEIAEKTNSVGIAHGCTGKGNDQVRFEVAIKALNPSLKAFAPVREWAWSREEEIDYAIKHNIPVSINHDSPYSIDQNLWGRANECGILEDPYAAPPEDAFDLTNALEETPDTADEIILTFDKGIPVQIDGKTYELDDLILTLNALAGKHGIGRIDHVENRLVGIKSREIYEAPAAEVILKAHKALETITLTKDVAHFKPIIEKQFAEQLYNGLWFSPLTDSLKLFIDSTQQYVSGDVRIKLFKGNAIVNGRKSPYTLYDEKLATYTKEDAFNQDAAVGFIDIYGLPTQVNAMLHGGYSNEQ
>NC_002951.2|WP_000148855.1|968470_969802_+|glucose-6-phosphate-isomerase
MTHIQLDFSKTLEFFGEHELKQQQEIVKSIHKTIHEGTGAGSDFLGWVDLPVDYDKEEFSRIVEASKRIKENSDVLVVIGIGGSYLGARAAIEMLTSSFRNSNEYPEIVFVGNHLSSTYTKELVDYLADKDFSVNVISKSGTTTEPAVAFRLFKQLVEERYGKEEAQKRIFATTDKEKGALKQLATNEGYETFIVPDDVGGRYSVLTAVGLLPIATAGINIEAMMIGAAKAREELSSDKLEENIAYQYATIRNILYAKGYTTEMLINYEPSMQYFNEWWKQLFGESEGKDFKGIYPSSANYTTDLHSLGQYVQEGRRFLFETVVKVNHPKYDITIEKDSDDLDGLNYLAGKTIDEVNTKAFEGTLLAHTDGGVPNMVVNIPQLDEETFGYVVYFFELACAMSGYQLGVNPFNQPGVEAYKQNMFALLGKPGFEDLKKELEERL
>NC_002951.2|WP_000007967.1|970126_970702_+|TVP38/TMEM64-family-protein
MSFHQVEEWFEIFRQFGYLPGFILLYIRAIIPVFPLALYILINIQAYGPILGILISWLGLISGTFTVYLICKRLVNTERMQRIKQRTAVQRLISFIDRQGLIPLFILLCFPFTPNTLINFVASLSHIRPKYYFIVLASSKLVSTIILGYLGKEITTILTHPLRGILMLVVLVVFWIVGKKLEQHFMGSKKE
>NC_002951.2|WP_000758215.1|970706_971231_+|signal-peptidase-I
MKKVVKYLISLILAIIIVLFVQTFVIVGHVIPNNDMSPTLNKGDRVIVNKIKVTFNQLNNGDIITYRRGNEIYTSRIIAKPGQSMAFRQGQLYRDDRPVDASYAKNRKIKDFSLRNFKELDGDIIPPNNFVVLNDQDNNKHDSRQFGLIDKKDIIGNVSLRYYPFSKWTVQFKS
>NC_002951.2|WP_000711486.1|971246_971822_+|signal-peptidase-I
MKKEILEWIISIAVAFVILFIVGKFIVTPYTIKGESMDPTLKDGERVAVNIVGYKTGGLEKGNVVVFHANKNDDYVKRVIGVPGDKVEYKNDTLYVNGKKQDEPYLNYNLKHKQGDYITGTFQVKDLPNANPKSNVIPKGKYLVLGDNREVSKDSRAFGLIDEDQIVGKVSFRFWPFSEFKHNFNPENTKN
>NC_002951.2|WP_000172345.1|971981_975458_+|helicase-exonuclease-AddAB-subunit-AddB
MTLHAYLGRAGTGKSTKMLTEIKQKMKADPLGDPIILIAPTQSTFQLEQAFVNDPELNGSLRTEVLHFERLSHRIFQEVGSYSEQKLSKAATEMMIYNIVQEQQKYLKLYQSQAKYYGFSEKLTEQIQDFKKYAVTPEHLEHFIADKNMQTRTKNKLEDIALIYREFEQRIQNEFITGEDSLQYFIDCMPKSEWLKRADIYIDGFHNFSTIEYLIIKGLIKYAKSVTIILTTDGNHDQFSLFRKPSEVLRHIEEIANELNISIERQYFNQLYRFNNQDLKHLEQEFDALQINRVACQGHINILESATMREEINEIARRIIVDIRDKQLRYQDIAILYRDESYAYLFDSILPLYNIPYNIDTKRSMTHHPVMEMIRSLIEVIQSNWQVNPMLRLLKTDVLTASYLKSAYLVDLLENFVLERGIYGKRWLDDELFNVEHFSKMGRKGHKLTEDERNTFEQVVKLKKDVIDKILHFEKQMSQAETVKDFATAFYESMEYFELPNQLMTERDELDLNGNHEKAEEIDQIWNGLIQILDDLVLVFGDEPMSMERFLEVFDIGLEQLEFVMIPQTLDQVSIGTMDLAKVDNKQHVYLVGMNDGTMPQPVTASSLITDEEKKYFEQQANVELSPTSDILQMDEAFVCYVAMTRAKGDVTFSYSLMGSSGDDKEISPFLNQIQSLFNQLEITNIPQYHEVNPLSLMQHAKQTKITLFEALRAWLYDEIVADSWLDAYQVIRDSDHLNQGLDYLMSALTFDNETVKLGETLSKDLYGKEINASVSRFEGYQQCPFKHYASHGLKLNERTKYELQNFDLGDIFHSVLKYISERINGDFKQLDLKKIRQLTNEALEEILPKVQFNLLNSSAYYRYLSRRIGAIVETTLSALKYQGTYSKFMPKHFETSFRRKPRTNDELIAQTLTTTQGIPINIRGQIDRIDTYTKNDTSFVNIIDYKSSEGSATLDLTKVYYGMQMQMMTYMDIVLQNKQRLGLTDIVKPGGLLYFHVHEPRIKFKSWSDIDEDKLEQDLIKKFKLSGLVNADQTVIDALDIRLEPKFTSDIVPVGLNKDGSLSKRGSQVADEATIYKFIQHNKENFIETASNIMDGHTEVAPLKYKQKLPCAFCSYQSVCHVDGMIDSKRYRTVDETINPIEAIQNININDEFGGEQ
>NC_002951.2|WP_000154930.1|975458_979112_+|helicase-exonuclease-AddAB-subunit-AddA
MTIPEKPQGVIWTDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADPANAHLKNQRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENILLLEQTIDEVIEQHYDILDPAFIELTEQLSSDRSDDQFRMIIKQLYFFSVANPNPTNWLDQLVTPYEEEAQQAQLIQLLTDLSKVFITAAYDALNKAYDLFSMMDSVDKHLAVIEDERRLMGRVLEGGFIDIPYLTGHEFGARLPNVTAKIKEANEMMVDALEDAKLQYKKYKSLIDKVKSDYFSREADDLKADMQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDGSPSEIAESYRQHFQEILVDEYQDTNRVQEKILSCIKTGDEHNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFTIDGDGTGRRIDLSQNFRSRKEVLSTTNYIFKHMMDEQVGEVKYDEAAQLYYGAPYDESDHPVNLKVLVEADQEHSDLTGSEQEAHFIVEQVKDILEHQKVYDMKTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRSVIYQFKEDELAQIRILSPNDDYFYQSIVNYINDEAADAILVDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVIQYFSGLIGGRGRRANLYGLFNKAIEFENSSFRGLYQFIRFIDELIERGKDFGEENVVGPNDNVVRMMTIHSSKGLEFPFVIYSGLSKDFNKRDLKQPVILNQQFGLGMDYFDVDKEMAFPSLASVAYRAVAEKELVSEEMRLVYVALTRAKEQLYLIGRVKNDKSLLELEQLSISGEHIAVNERLTSPNPFHLIYSILSKHQSASIPDDLKFEKDIAQIEDSSRPNVNISIVYFEDVSTETILDNDEYRSVNQLETMQNGNEDVKAQIKHQLDYRYPYVNDTKKPSKQSVSELKRQYETEESGTSYERVRQYRIGFSTYERPKFLSEQGKRKANEIGTLMHTVMQHLPFKKERISEVELHQYIDGLIDKHIIEADAKKDIRMDEIMTFINSELYSIIAEAEQVYRELPFVVNQALVDQLPQGDEDVSIIQGMIDLIFVKDGVHYFVDYKTDAFNRRRGMTDEEIGTQLKNKYKIQMKYYQNTLQTILNKEVKGYLYFFKFGTLQL
>NC_002951.2|WP_000670752.1|979277_980180_+|fumarylacetoacetate-hydrolase-family-protein
MKFLSFKYNDKTSYGVKVKREDAVWDLTQVFADFAEGDFHPKTLLAGLQQNHTLDFQEQVRKAVVAAEDSGKAEDYKISFNDIEFLPPVTPPNNVIAFGRNYKDHANELNHEVEKLYVFTKAASSLTGDNATIPNHKDITDQLDYEGELGIVIGKSGEKIPKALALDYVYGYTIINDITDRKAQSEQDQAFLSKSLTGGCPMGPYIVTKDELPLPENVNIVTKVNNEIRQDGNTGEMILKIDELIEEISKYVALHPGDIIATGTPAGVGAGMQPPKFLQPGDEVKVTIDNIGTLTTYIAK

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Crispr_ID: NC_002951_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002951_7

1182189-1182375

Orphan

Consensus_repeat	Method
GGCGGGGCCCCAACATAGA	CRT

3 spacers

The CRISPR arrays of NC_002951_7

>merge|NC_002951|7|1182189-1182375|CRT
GGCGGGGCCCCAACATAGAGAATTTCAAAAAGAAATTCTACAGACAATGCAAGTTGGGGTGGGCCCCAACACAGAAGCTGACGAAAAGTCAGCTTACAATAATGTGCAAGTTGGCGGGGCCCCAACATAGTGAAATTGGATTCCCAATTTCTACAGACAATGCAAGTTGGCGGGGCCCCAACATAGA

>NC_002951|7|2|1182189-1182375|CRT
GGCGGGGCCCCAACATAGA	GAATTTCAAAAAGAAATTCTACAGACAATGCAAGTTG
GGGTGGGCCCCAACACAGA	AGCTGACGAAAAGTCAGCTTACAATAATGTGCAAGTT
GGCGGGGCCCCAACATAGT	GAAATTGGATTCCCAATTTCTACAGACAATGCAAGTT
GGCGGGGCCCCAACATAGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_002951.2\|WP_000739563.1\|1174895_1175297_-\|formyl-peptide-receptor-like-1-inhibitory-protein	unknown	unknown	gnl\|CDD\|171849
NC_002951.2\|WP_000041896.1\|1182589_1183306_-\|superantigen-like-protein-SSL12	unknown	unknown	gnl\|CDD\|171995
NC_002951.2\|WP_000791587.1\|1176733_1177231_+\|complement-convertase-inhibitor-Efb	unknown	unknown	gnl\|CDD\|289007
NC_002951.2\|WP_001032814.1\|1178556_1178742_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_001239285.1\|1189920_1190868_-\|TDT-family-transporter	unknown	unknown	gnl\|CDD\|187765
NC_002951.2\|WP_001802045.1\|1181808_1182033_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000765708.1\|1181705_1181852_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000231632.1\|1179363_1179597_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000857483.1\|1180073_1181033_-\|alpha-hemolysin	unknown	unknown	gnl\|CDD\|273388
NC_002951.2\|WP_001074342.1\|1186420_1187353_+\|carbamate-kinase	unknown	unknown	gnl\|CDD\|237071
NC_002951.2\|WP_000669537.1\|1177384_1177735_+\|complement-inhibitor-SCIN-B	unknown	unknown	gnl\|CDD\|371594
NC_002951.2\|WP_000398672.1\|1192216_1192351_+\|beta-class-phenol-soluble-modulin	unknown	unknown	gnl\|CDD\|368464
NC_002951.2\|WP_000432077.1\|1187524_1189081_+\|YfcC-family-protein	unknown	unknown	gnl\|CDD\|224207
NC_002951.2\|WP_000584398.1\|1175968_1176475_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_001245802.1\|1191116_1191305_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225382
NC_002951.2\|WP_000739523.1\|1184233_1184959_-\|superantigen-like-protein-SSL14	unknown	unknown	gnl\|CDD\|171855
NC_002951.2\|WP_001063559.1\|1183413_1184139_-\|superantigen-like-protein-SSL13	unknown	unknown	gnl\|CDD\|106307
NC_002951.2\|WP_001791789.1\|1174843_1174936_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000149427.1\|1189388_1189616_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000793605.1\|1185396_1186398_+\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|235269

Protein	Function_ID	Function_description	E-value
NC_002951.2\|WP_000739563.1\|1174895_1175297_-\|formyl-peptide-receptor-like-1-inhibitory-protein	gnl\|CDD\|171849	PRK13033, PRK13033, formyl peptide receptor-like 1 inhibitory protein; Reviewed.	3.87075e-77
NC_002951.2\|WP_000041896.1\|1182589_1183306_-\|superantigen-like-protein-SSL12	gnl\|CDD\|171995	PRK13350, PRK13350, superantigen-like protein; Reviewed.	1.29441e-152
NC_002951.2\|WP_000791587.1\|1176733_1177231_+\|complement-convertase-inhibitor-Efb	gnl\|CDD\|289007	pfam12199, efb-c, Extracellular fibrinogen binding protein C terminal. This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade.	5.40265e-27
NC_002951.2\|WP_000857483.1\|1180073_1181033_-\|alpha-hemolysin	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	4.27434e-141
NC_002951.2\|WP_001245802.1\|1191116_1191305_+\|hypothetical-protein	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	0.00787195
NC_002951.2\|WP_001063559.1\|1183413_1184139_-\|superantigen-like-protein-SSL13	gnl\|CDD\|106307	PRK13349, PRK13349, superantigen-like protein; Reviewed.	1.29834e-148
NC_002951.2\|WP_001074342.1\|1186420_1187353_+\|carbamate-kinase	gnl\|CDD\|237071	PRK12353, PRK12353, putative amino acid kinase; Reviewed.	0
NC_002951.2\|WP_001239285.1\|1189920_1190868_-\|TDT-family-transporter	gnl\|CDD\|187765	cd09325, TDT_C4-dicarb_trans, C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.	7.44089e-84
NC_002951.2\|WP_000669537.1\|1177384_1177735_+\|complement-inhibitor-SCIN-B	gnl\|CDD\|371594	pfam11546, CompInhib_SCIN, Staphylococcal complement inhibitor SCIN. SCIN is released by Staphylococcus aureus to counteract the host immune defense. The protein binds to and inhibits C3 convertases on the bacterial surface, reducing phagocytosis and blocking downstream effector functions by C3b deposition on its surface. An 18 residue stretch 31-48 is crucial for SCIN activity.	2.0882e-48
NC_002951.2\|WP_000398672.1\|1192216_1192351_+\|beta-class-phenol-soluble-modulin	gnl\|CDD\|368464	pfam05480, Staph_haemo, Staphylococcus haemolytic protein. This family consists of several different short Staphylococcal proteins, it contains SLUSH A, B and C proteins as well as haemolysin and gonococcal growth inhibitor. Some strains of the coagulase-negative Staphylococcus lugdunensis produce a synergistic hemolytic activity (SLUSH), phenotypically similar to the delta-hemolysin of S. aureus. Gonococcal growth inhibitor from Staphylococcus act on the cytoplasmic membrane of the gonococcal cell causing cytoplasmic leakage and, eventually, death.	6.35158e-13
NC_002951.2\|WP_000739523.1\|1184233_1184959_-\|superantigen-like-protein-SSL14	gnl\|CDD\|171855	PRK13043, PRK13043, superantigen-like protein; Reviewed.	8.18566e-161
NC_002951.2\|WP_000432077.1\|1187524_1189081_+\|YfcC-family-protein	gnl\|CDD\|224207	COG1288, COG1288, Predicted membrane protein [Function unknown].	0
NC_002951.2\|WP_000793605.1\|1185396_1186398_+\|ornithine-carbamoyltransferase	gnl\|CDD\|235269	PRK04284, PRK04284, ornithine carbamoyltransferase; Provisional.	0

>NC_002951.2|WP_001802045.1|1181808_1182033_+|hypothetical-protein
MLIQERGLKMTELNNIINSLQSLFESESGYKISKNSGVPYQTVQDLRNGKTKLEDARFRTIIKLYSYYVSLKEH
>NC_002951.2|WP_000765708.1|1181705_1181852_+|hypothetical-protein
MKLFYIVFLIIIWLNIFLGNEIIHTLTVLITTLYIVNSRKGIKNDRVE
>NC_002951.2|WP_000857483.1|1180073_1181033_-|alpha-hemolysin
MKTRIVSSVTTTLLLGSILMNPVANAADSDINIKTGTTDIGSNTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWIDRSSERYKIDWEKEEMTN
>NC_002951.2|WP_000231632.1|1179363_1179597_-|hypothetical-protein
MVFNDWEINVVYSGEHEVVTNEKSLFVIDEFYDVAIAIYYLDGKLKVAHVNYGSDFTIDVANKVFELNIQNPNVDEH
>NC_002951.2|WP_001032814.1|1178556_1178742_-|hypothetical-protein
MNKHINKKAAKLLEDYKKVQQRKSKETDRGCLKSVIMLIVLFFLIIFGIVACSTNVNFFFQ
>NC_002951.2|WP_000669537.1|1177384_1177735_+|complement-inhibitor-SCIN-B
MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSNVYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
>NC_002951.2|WP_000791587.1|1176733_1177231_+|complement-convertase-inhibitor-Efb
MKNKLIAKSLLTLAAIGITTTTIASTADASEGYGPREKKPVSINHNIVEYNDGTFKYQSRPKFNSTPKYIKFKHDYNILEFNDGTFEYGARPQFNKPAAKTDATIKKEQKLIQAQNLVREFEKTHTVSAHRKAQKAVNLVSFEYKVKKMVLQERIDNVLKQGLVK
>NC_002951.2|WP_000584398.1|1175968_1176475_+|hypothetical-protein
MIIKILTILLLLCILSYLVTNRKKPFLFLKTLFMGVVFIFIGYISLAISAVIIYGIIQFITIDFGSFFLMGIILILISSIFQLFIVRLLFRKKNVDLTEVVVLEHLIQWFLVYFAIYQAVNEKMDINDINIDNFQSVFFDVSNLNLVILPTLIISWVTIFNYRMRSYK
>NC_002951.2|WP_000739563.1|1174895_1175297_-|formyl-peptide-receptor-like-1-inhibitory-protein
MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERIDKLMKESDKNLTPYKAETVNDLYLIVKKLSQGDVKKAVVRIKDGGPRDYYTFDLTRPLEENRKNIKVVKNGEIDSITWY
>NC_002951.2|WP_001791789.1|1174843_1174936_-|hypothetical-protein
MLKTVKSTRLLGIKKHTELNSCTPNVRKQC
>NC_002951.2|WP_000041896.1|1182589_1183306_-|superantigen-like-protein-SSL12
MSKNITKNIILTTTLLLLGTVLPQNQKPVFSFYSEAKAYSIGQDETNINELIKYYTQPHFSFSNKWLYQYDNGNIYVELKRYSWSAHISLWGAESWGNINQLKDRYVDVFGLKDKDTDQLWWSYRETFTGGVTPAAKPSDKTYNLFVQYKDKLQTIIGAHKIYQGNKPVLTLKEIDFRAREALIKNKILYNENRNKGKLKITGGGNNYTIDLSKRLHSDLANVYVKNPNKITVDVLFD
>NC_002951.2|WP_001063559.1|1183413_1184139_-|superantigen-like-protein-SSL13
MNNNITKKIILSTTLLLLGTASTQFPNTPINSSSEAKAYYINQNETNVNELTKYYSQKYLTFSNSTLWQKDNGTIHATLLQFSWYSHIQVYGPESWGNINQLRNKSVDIFGIKDQETIDSFALSQETFTGGVTPAATSNDKHYKLNVTYKDKAETFTGGFPVYEGNKPVLTLKELDFRIRQTLIKSKKLYNNSYNKGQIKITGADNNYTIDLSKRLPSTDANRYVKKPQNAKIEVILEKSN
>NC_002951.2|WP_000739523.1|1184233_1184959_-|superantigen-like-protein-SSL14
MKKNIMNKLVLSTALLLLETTSTQLPKTPISFSSEAKAYNISENETNINELIKYYTQPHFSLSGKWLWQKPNGSIHATLQTWVWYSHIQVFGSESWGNINQLRNKYVDIFGTKDEDTVEGYWTYDETFTGGVTPAATSSDKPYRLFLKYSDKQQTIIGGHEFYKGNKPVLTLKELDFRIRQTLIKNKKLYNGEFNKGQIKITADGNNYTIDLSKKLKLTDTNRYVKNPRNAEIEVILEKSN
>NC_002951.2|WP_000793605.1|1185396_1186398_+|ornithine-carbamoyltransferase
MKNLRNRSFLTLLDFSRQEVEFLLTLSEDLKRAKYIGTEKPMLKNKNIALLFEKDSTRTRCAFEVAAHDQGANVTYLGPTGSQMGKKETTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEVLKKDYADINFTYVGDGRNNVANALMQGAAIMGMNFHLVCPKELNPTDELLNRCKNIAAENGGNILITDDIDQGVKGSDVIYTDVWVSMGEPDEVWKERLELLKPYQVNKEIMDKTGNPNVIFEHCLPSFHNADTKIGQQIFEKYGIREMEVTDEVFESKASVVFQEAENRMHTIKAVMVATLGEF
>NC_002951.2|WP_001074342.1|1186420_1187353_+|carbamate-kinase
MAKIVVALGGNALGKSPQEQLELVKNTAKSLVGLITKGHEIVISHGNGPQVGSINLGLNYAAEHNQGPAFPFAECGAMSQAYIGYQLQESLQNELHSIGMDKQVVTLVTQVEVDENDPAFNNPSKPIGLFYNKEEAEQIQKEKGFIFVEDAGRGYRRVVPSPQPISIIELESIKTLIKNDTLVIAAGGGGIPVIREQHDGFKGIDAVIDKDKTSALLGANIQCDQLIILTAIDYVYINFNTENQQPLKTTNVDELKRYIDENQFAKGSMLPKIEAAISFIENNPKGSVLITSLNELDAALEGKVGTVIKK
>NC_002951.2|WP_000432077.1|1187524_1189081_+|YfcC-family-protein
MENTINESEKKKRFKLKMPGAFMILFILTVVAVIATWVIPAGAYSKLSYEPSSQELKIVNPHNQVKKVPGTQQELDKMGVKIKIEQFKSGAINKPVSIPNTYERLKQHPAGPEQITSSMVEGTIEAVDIMVFILVLGGLIGVVQASGSFESGLLALTKKTKGHEFMLIVFVSILMIIGGTLCGIEEEAVAFYPILVPIFIALGYDSIVSVGAIFLASSVGSTFSTINPFSVVIASNAAGTTFTDGLYWRIGACIVGAIFVISYLYWYCKKIKNDPKASYSYEDKDAFEQQWSVLKDDDSAHFTLRKKIILTLFVLPFPIMVWGVMTQGWWFPVMASAFLIFTIIIMFIAGTGKSGLGEKGTVDAFVNGASSLVGVSLIIGLARGINLVLNEGMISDTILHFSSSLVQHMSGPLFIIVLLFIFFCLGFIVPSSSGLAVLSMPIFAPLADTVGIPRFVIVTTYQFGQYAMLFLAPTGLVMATLQMLNMRYSHWFRFVWPVVAFVLIFGGGVLITQVLIYS
>NC_002951.2|WP_000149427.1|1189388_1189616_+|hypothetical-protein
MTHLTKVLDTLTGICVVLLFSKYFVVYANMVFDWNLRWYLLENIPHLPIILFILMFIFGVPSEMIKDRQRKNNGV
>NC_002951.2|WP_001239285.1|1189920_1190868_-|TDT-family-transporter
MRLQKAPLVTSGLVLGLLGLGNLLKDLSLTLNAVCGIFAFLIWIHLLCTMIKYFNNVKEQLNSPLVSSVFTTFFMSGFLGTTYLNTFFSNITFINSLITPIWILCLVGIMTHMIIFSIKYLKDFSLENVYPSWTVLFIGIAIAGLTAPVSGYFFIGQLTVIYGFVATCIVLPIVFKRLKAFPLQTSIKPNTSTICAPFSLVAAAYVIAFPKANAFIVIIFLLLAQIFYFYIIIQLPKLLKEPFSPVFSAFTFPLVISATALKNSLPVLMFPDIWKGLLFIEVLLATVIVLRVFIGYLHFFLKKEKQDKFLRNASQ
>NC_002951.2|WP_001245802.1|1191116_1191305_+|hypothetical-protein
MRNQIQKLLDSDLSSLHISKQTGVPQSTIHRMRKNERSLDNMSLKNAELLYKFANSIFSNEN
>NC_002951.2|WP_000398672.1|1192216_1192351_+|beta-class-phenol-soluble-modulin
MEGLFNAIKDTVTAAINNDGAKLGTSIVSIVENGVGLLGKLFGF

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Crispr_ID: NC_002951_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002951_8

1850407-1850633

Orphan

Consensus_repeat	Method
GGGCCCCAACACAGAAGCTGGCCAATAGTCAGCTTTCAATAATGTGCAAGTTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_002951_8

>merge|NC_002951|8|1850407-1850633|CRISPRCasFinder
GGGCCCCAACATAGAAGCTGGCCAATAGTTAGCTTTCAATAATGTGCAAGTTGGGGTAAGGGCCCCAACACAGAAGCTGGCCAATAGTCAGCTTTCAATAATGTGCAAGTTGGGGTAAGGGCCCCAACACAGAGAATTTCGAAAAGAAATTCTACAGACAATGCAAGTTGGCGGGGCCCCAACACAGAAGCTGGCCAATAGTCAGCTTTCAATAATGTGCAAGTTGG

>NC_002951|8|6|1850407-1850633|CRISPRCasFinder
GGGCCCCAACATAGAAGCTGGCCAATAGTTAGCTTTCAATAATGTGCAAGTTGG	GGTAAGGGCCCCAACACAGAAGCTGGCCAATAGTCAGCTTTCAATAATGTGCAAGTTGGGGTAAGGGCCCCAACACAGAGAATTTCGAAAAGAAATTCTACAGACAATGCAAGTTGGCG
GGGCCCCAACACAGAAGCTGGCCAATAGTCAGCTTTCAATAATGTGCAAGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_002951.2\|WP_000434765.1\|1846490_1847282_-\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|223584
NC_002951.2\|WP_001048368.1\|1840962_1841559_-\|DUF4479-domain-containing-tRNA-binding-protein	unknown	unknown	gnl\|CDD\|234804
NC_002951.2\|WP_000004335.1\|1852143_1853805_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
NC_002951.2\|WP_001050554.1\|1855596_1862157_-\|LPXTG-anchored-repetitive-surface-protein-SasC	unknown	unknown	gnl\|CDD\|275089
NC_002951.2\|WP_000163826.1\|1844083_1844395_+\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|227871
NC_002951.2\|WP_001549041.1\|1862815_1865233_-\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NC_002951.2\|WP_000526539.1\|1866811_1867765_+\|TIGR01212-family-radical-SAM-protein	unknown	unknown	gnl\|CDD\|224163
NC_002951.2\|WP_000265417.1\|1848683_1850093_-\|Mn(2+)-dependent-dipeptidase-Sapep	unknown	unknown	gnl\|CDD\|235988
NC_002951.2\|WP_000689580.1\|1844519_1845362_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293814
NC_002951.2\|WP_001024576.1\|1842920_1843997_-\|M42-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349906
NC_002951.2\|WP_000285019.1\|1854211_1855480_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|367519
NC_002951.2\|WP_001051860.1\|1851012_1851435_-\|YtxH-domain-containing-protein	unknown	unknown	gnl\|CDD\|378938
NC_002951.2\|WP_001025061.1\|1865520_1866702_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NC_002951.2\|WP_000411085.1\|1847831_1848680_-\|D-amino-acid-transaminase	unknown	unknown	gnl\|CDD\|130191
NC_002951.2\|WP_000811163.1\|1842544_1842856_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_002951.2\|WP_001266167.1\|1845831_1846476_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NC_002951.2\|WP_001091386.1\|1841587_1842445_-\|DUF1444-domain-containing-protein	unknown	unknown	gnl\|CDD\|237463
NC_002951.2\|WP_000836465.1\|1862482_1862794_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NC_002951.2\|WP_000764419.1\|1867761_1868325_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|377744
NC_002951.2\|WP_001217125.1\|1851451_1852147_-\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108

Protein	Function_ID	Function_description	E-value
NC_002951.2\|WP_000434765.1\|1846490_1847282_-\|phosphotransferase-family-protein	gnl\|CDD\|223584	COG0510, ycfN, Thiamine kinase and related kinases [Coenzyme transport and metabolism].	5.2385e-83
NC_002951.2\|WP_001048368.1\|1840962_1841559_-\|DUF4479-domain-containing-tRNA-binding-protein	gnl\|CDD\|234804	PRK00629, pheT, phenylalanyl-tRNA synthetase subunit beta; Reviewed.	7.47641e-48
NC_002951.2\|WP_000004335.1\|1852143_1853805_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.63186e-123
NC_002951.2\|WP_001050554.1\|1855596_1862157_-\|LPXTG-anchored-repetitive-surface-protein-SasC	gnl\|CDD\|275089	TIGR04263, cell_wall_surface_anchor_family_protein, SasC/Mrp/FmtB intercellular aggregation domain. This domain, about 375 amino acids long on average, occurs only in Staphylococcus and Streptococcus. It occurs as a non-repetitive N-terminal domain of LPXTG-anchored surface proteins, including SasC, Mrp, and FmtB. This region in SasC was shown to be involved in cell aggregation and biofilm formation, which may explain the methicillin resistance seen for Mrp and FmtB.	2.88213e-115
NC_002951.2\|WP_000163826.1\|1844083_1844395_+\|PepSY-domain-containing-protein	gnl\|CDD\|227871	COG5584, COG5584, Predicted small secreted protein [Function unknown].	4.78628e-46
NC_002951.2\|WP_001549041.1\|1862815_1865233_-\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NC_002951.2\|WP_000526539.1\|1866811_1867765_+\|TIGR01212-family-radical-SAM-protein	gnl\|CDD\|224163	COG1242, COG1242, Predicted Fe-S oxidoreductase [General function prediction only].	0
NC_002951.2\|WP_000265417.1\|1848683_1850093_-\|Mn(2+)-dependent-dipeptidase-Sapep	gnl\|CDD\|235988	PRK07318, PRK07318, dipeptidase PepV; Reviewed.	0
NC_002951.2\|WP_000689580.1\|1844519_1845362_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293814	cd07728, YtnP-like_MBL-fold, Bacillus subtilis YtnP and related proteins; MBL-fold metallo hydrolase domain. Bacillus subtilis YtnP inhibits the signaling pathway required for the streptomycin production and development of aerial mycelium in Streptomyces griseus. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.38932e-155
NC_002951.2\|WP_001024576.1\|1842920_1843997_-\|M42-family-metallopeptidase	gnl\|CDD\|349906	cd05656, M42_Frv, M42 Peptidase, endoglucanases. Peptidase M42 family, Frv (Frv Operon Protein; Endo-1 4-Beta-Glucanase; Cellulase Protein; Endoglucanase; Endo-1 4-Beta-Glucanase Homolog; Glucanase; EC. 3.2.1.4) subfamily. Frv is a co-catalytic metallopeptidase, found in archaea and bacteria, including Pyrococcus horikoshii tetrahedral shaped phTET1 (DAPPh1; FrvX; PhDAP aminopeptidase; PhTET aminopeptidase; deblocking aminopeptidase), phTET2 (DAPPh2) and phTET3 (DAPPh3), Haloarcula marismortui TET (HmTET) as well as Bacillus subtilis YsdC. All of these exhibit aminopeptidase and deblocking activities. The HmTET is a broad substrate aminopeptidase capable of degrading large peptides. PhTET2, which shares 24% identity with HmTET, is a cobalt-activated peptidase and possibly a deblocking aminopeptidase, assembled as a 12-subunit tetrahedral dodecamer, while PhTET1 can be alternatively assembled as a tetrahedral dodecamer or as an octahedral tetracosameric structure. The active site in such a self-compartmentalized complex is located on the inside such that substrate sizes are limited, indicating function as possible peptide scavengers. PhTET2 cleaves polypeptides by a nonprocessive mechanism, preferring N-terminal hydrophobic or uncharged polar amino acids. Streptococcus pneumoniae PepA (SpPepA) also forms dodecamer with tetrahedral architecture, and exhibits selective substrate specificity to acidic amino acids with the preference to glutamic acid, with the substrate binding S1 pocket containing an Arg allows electrostatic interactions with the N-terminal acidic residue in the substrate. The YsdC gene is conserved in a number of thermophiles, archaea and pathogenic bacterial species; the closest structural homolog is Thermotoga maritima FrwX (34% identity), which is annotated as either a cellulase or an endoglucanase, and is possibly involved in polysaccharide biosynthesis or degradation.	2.36515e-152
NC_002951.2\|WP_000285019.1\|1854211_1855480_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|367519	pfam03486, HI0933_like, HI0933-like protein.	0
NC_002951.2\|WP_001051860.1\|1851012_1851435_-\|YtxH-domain-containing-protein	gnl\|CDD\|378938	pfam12732, YtxH, YtxH-like protein. This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 143 amino acids in length. The N-terminal region is the most conserved. Proteins is this family are functionally uncharacterized.	0.000542053
NC_002951.2\|WP_001025061.1\|1865520_1866702_-\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.66072e-94
NC_002951.2\|WP_000411085.1\|1847831_1848680_-\|D-amino-acid-transaminase	gnl\|CDD\|130191	TIGR01121, D-alanine_aminotransferase, D-amino acid aminotransferase. This enzyme is a homodimer. The pyridoxal phosphate attachment site is the Lys at position 146 of the seed alignment, in the motif Cys-Asp-Ile-Lys-Ser-Leu-Asn. Specificity is broad for various D-amino acids, and differs among members of the family; the family is designated equivalog, but with this caveat attached. [Energy metabolism, Amino acids and amines].	6.28892e-159
NC_002951.2\|WP_000811163.1\|1842544_1842856_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.34221e-24
NC_002951.2\|WP_001266167.1\|1845831_1846476_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	1.40225e-87
NC_002951.2\|WP_001091386.1\|1841587_1842445_-\|DUF1444-domain-containing-protein	gnl\|CDD\|237463	PRK13668, PRK13668, hypothetical protein; Provisional.	2.48009e-168
NC_002951.2\|WP_000836465.1\|1862482_1862794_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	1.46882e-25
NC_002951.2\|WP_000764419.1\|1867761_1868325_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|377744	pfam06962, rRNA_methylase, Putative rRNA methylase. This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.	2.38341e-67
NC_002951.2\|WP_001217125.1\|1851451_1852147_-\|rRNA-pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	2.1062e-94

>NC_002951.2|WP_000265417.1|1848683_1850093_-|Mn(2+)-dependent-dipeptidase-Sapep
MWKEKVQQYEDQIINDLKGLLAIESVRDDAKASEDAPVGPGPRKALDYMYEIAHRDGFTTHDVDHIAGRIEAGKGNDVLGILCHVDVVPAGDGWDSNPFEPVVTEDAIIARGTLDDKGPTIAAYYAIKILEDMNVDWKKRIHMIIGTDEESDWKCTDRYFKTEEMPTLGFAPDAEFPCIHGEKGITTFDLVQNKLTEDQDEPDYELITFKSGERYNMVPDHAEARVLVKENMTDVIQDFEYFLEQNHLQGDSTVDSGILVLTVEGKAVHGMDPSIGVNAGLYLLKFLASLNLDNNAQAFVAFSNRYLFNSDFGEKMGMKFHTDVMGDVTTNIGVITYDNENAGLFGINLRYPEGFEFEKAMDRFANEIQQYGFEVKLGKVQPPHYVDKNDPFVQKLVTAYRNQTNDMTEPYTIGGGTYARNLDKGVAFGAMFSDSEDLMHQKNEYITKKQLFNATSIYLEAIYSLCVEE
>NC_002951.2|WP_000411085.1|1847831_1848680_-|D-amino-acid-transaminase
MEKIFLNGEFVSPSEAKVSYNDRGYVFGDGIYEYIRVYNGKLFTVTEHYERFLRSANEIGLDLNYSVEELIELSRKLVDMNQIETGAIYIQATRGVAERNHSFPTPEVEPAIVAYTKSYDRPYDHLENGVNGVTVEDIRWLRCDIKSLNLLGNVLAKEYAVKYNAVEAIQHRGETVTEGSSSNAYAIKDGVIYTHPINNYILNGITRIVIKKIAEDYNIPFKEETFTVDFLKNADEVIVSSTSAEVTPVIKLDGEPVNDGKVGPITRQLQEGFEKYIESHSI
>NC_002951.2|WP_000434765.1|1846490_1847282_-|phosphotransferase-family-protein
MEQFYQLGWTLDSAGGASGEAYMAEQDGQKLFLKRNSNPFIAALSAEGIVPKLVWTKRIETGEVVTAQHWKNGRELSSNEMKQTRVAHLLKKIHNSRPLLSMLKRMEMEPITPEIMLNKINASLSREVLTHHIVRKSLTYLEEHIPSLDSRFFTVVHGDVNHNNWLLSDRDELFLVDWEGAMIADPAIDIGMLLYNYVPQQQWSEWLETYGVQESLNLNKRMKWYTVIQSIGLVQWYEEQKRYKDMNTWLKFLNEVMNSNMFI
>NC_002951.2|WP_001266167.1|1845831_1846476_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MRVRYKPWAKDYLKDHPELVDMDGQHAGKMTEWFDKTQPIHIEIGSGMGQFITTLAAQNPHINYISMEREKSIVYKVLDKVKEMGLTNLKIICNDAIELNEYFKDGEVSRIYLNFSDPWPKNRHAKRRLTYHTFLALYQQILNDEGDLHFKTDNRGLFAYSLESMSQFGMYFTKINLNLHQEDDGSNILTEYEKKFSDKGSRIYRMEAKFHSQK
>NC_002951.2|WP_000689580.1|1844519_1845362_-|MBL-fold-metallo-hydrolase
MKIGDISIHYLNGGNTKMDGGAMFGVVPKPLWSKQYNANERNQINLPTHPILIQTAQYNLIIDAGIGNGKLSEKQLRNFGVDEESHIIADLANYNLTPKDIDYVLMTHMHFDHAAGLTDQAGHAIFENAIHVVQQDEWHEFIAPNIRSKSTYWDKNKGDYSNKLILFEKHFEPVLGIKMQHSGGHSFGHTIITIESQGDKAVHMGDIFPTTAHKNPLWVTAYDDYPMQSIREKERMIPYFIQQQYWFLFYHDENYFAVKYSDNGENIDAYILRETLVDNN
>NC_002951.2|WP_000163826.1|1844083_1844395_+|PepSY-domain-containing-protein
MTKLKYIIPTIIAVAIVIISTISIIQFINRKRYNPVKVLNEVKSYFMNVKGSYIVYEPFVHPETDKYRLVYQGGITTIKNGQNIHYDFYADAYTGEVINIVER
>NC_002951.2|WP_001024576.1|1842920_1843997_-|M42-family-metallopeptidase
MNINKKVTLQRIQTLTELHGAPGFEEEVKNYMTQQMAPYVDEFIENRMGGFFGVKKSKNPNAKRVMIAAHMDEIGFMITNITKNGMIQFTNLGGVANDIWQGQRLVIKNRNGDKIIGVVSNIPKHFRTGSEGAPEIKDLTLDIGAQNEDEVRERGIDIGDTIVPHTPFTQLSEHRYSAKAWDNRYGCVLAIEILELLKDIELDVDLYVGANVQEEVGLRGAKASAEMIDPDVAFVVDCSPANDVKGNQPLSGELGKGTLIRIKDGTMILKPVFRDYLLKLVEAHDIEHQYYMSPGGTDGGEIHKANIGIPTAVIGVCARYIHSTDSVFDIRDYFAARSLLSEAICNLDNNQIETLQYK
>NC_002951.2|WP_000811163.1|1842544_1842856_-|thioredoxin-family-protein
MKQLESEQQFESLKQGATVFEFTAGWCPDCRVIEPDLPELEARYPMFDFVSVDRDKFMDICIENGIMGIPSFLVYKNGELLGSYIGKERKSIEQIDAFLAQYV
>NC_002951.2|WP_001091386.1|1841587_1842445_-|DUF1444-domain-containing-protein
MNTFQMRDKLKERLSHLDVDFKFNREEETLRIYRTDNNKGITIKLNAIVAKYEDKKEKIVDEIVYYVDEAIAQMADKTLESISSSQIMPVIRATSFDKKTKQGVPFIYDEHTAETAVYYAVDLGKSYRLIDESMLEDLKLTEQQIREMSLFNVRKLSNSYTTDEVKGNIFYFINSNDGYDASRILNTAFLNEIEAQCQGEMLVAVPHQDVLIIADIRNKTGYDVMAHLTMEFFTKGLVPITSLSFGYKQGHLEPIFILGKNNKQKRDPNVIQRLEANRRKFDKDK
>NC_002951.2|WP_001048368.1|1840962_1841559_-|DUF4479-domain-containing-tRNA-binding-protein
MNLFYNPKYVGDVAFLQIEPVEGELNYNKKGNVVEITNEGNVVGYNIFEISKDITIEEKGHIKLTDELVNVFQKRISEAGFDYKLNADLSPKFVVGYVETKDKHPDADKLSVLNVNVGNDTLQIVCGAPNVEAGQKVVVAKVGAVMPSGMVIKDAELRGVASSGMICSMKELNLPNAPEEKGIMVLNDSYEIGQAFFE
>NC_002951.2|WP_001051860.1|1851012_1851435_-|YtxH-domain-containing-protein
MAKGNLFKAILGIGGAVAAVLVTRKDSRDKLKAEYNKYKQDPQSYKDNAKDKATQLGTIANETIKEVKTNPKEYANRLKNNPKAFFKEEKSKFTEYDNKTDESIEKGKFDDEGGAAPNNNLRIVTEEDLKKNKNALSDKE
>NC_002951.2|WP_001217125.1|1851451_1852147_-|rRNA-pseudouridine-synthase
MRIDKFLANMGVGTRNEVKQLLKKGLVNVNEQVIKSPKTHIEPENDKITVRGELIEYIENVYIMLNKPKGYISATEDHHSKTVIDLIPEYQHLNIFPVGRLDKDTEGLLLITNDGDFNHELMSPNKHVSKKYEVISANPITEDDIQAFKEGVTLTDGKVKPAILTYIDNQTSHVTIYEGKYHQVKRMFHSIQNEVLHLRRIKIADLELDSNLDSGEYRLLTENDFDKLNYK
>NC_002951.2|WP_000004335.1|1852143_1853805_-|polysaccharide-biosynthesis-protein
MSESKEMVRGTFLITISILITKVLGVLFIIPFNYLIGGQENMAPFTYAYAPYNIAIAVATAGVPLAASKYVAKYNAIGAYKVSQKFYKSSFIVMSITGVLGFLVLYFLAPYISELTLARNIHDKNGWSVDDITWIIRIISMVVIFIPVLATWRGIFQGYKSMGPTAVSEVTEQIARVIFILIGSYLVLNVFDGSILLANGIATFAAAVGAIIGIFTLWYYWRKRKHNIDRMVESDYTDIDVSYGKMYKEIIAYSIPFVIVSLNYPLFNLVDQFTHNGALSLVGIPSQLQDIFFNMLNMSTNKIVMIPTSLSAGFAVSLIPYITKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYGYDPIVLGHDPNHDGSRLLFYYAPVAILISLLSVTASMLQGIDKQKLTVYVILASVVIKLALNYPLIMLFHTPGAILSTSIALLFAIGCNFYILKKYAKFKFSYSWIHFAKIFLYSFIMMLGVELVFFLANLFLEPTKLGYLIIIILGVTVGILIYGTITIKTRLADEFLGEIPEKLRRRVRFLR
>NC_002951.2|WP_000285019.1|1854211_1855480_+|NAD(P)/FAD-dependent-oxidoreductase
MYQTIIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGRCNVTNRLPYAEIIKNIPGNGKFLYSPFSIFDNESIIDFFESRGVKLKEEDHGRMFPVSNKAQDVVDTLVTTIERQHVTIKEEEAVSRIEVNTDQTFTVHTQNNSYESHSLVIATGGTSVPQTGSTGDGYKFAQDLGHTITELFPTEVPITSAEPFIKSNRLKGLSLKDVELSVLKKNGKKRISHQMDMLFTHFGISGPAALRCSQFVYKEQKNQKTQHISMAIDAFPELNHEQLKQHITSLLSDTPDKIIKNSLHGLIEERYLLFMLEQAGIDENTTSHHLSNQQLNDLVNMFKGFVFKVNGTLPIDKAFVTGGGVSLKEIQPKTMMSKLVPGLFLCGEVLDIHGYTGGYNITSALVTGHVAGLYAGHYSHASME
>NC_002951.2|WP_001050554.1|1855596_1862157_-|LPXTG-anchored-repetitive-surface-protein-SasC
MNLLKKNKYSIRKYKVGIFSTLIGTVLLLSNPNGAQALTTDNNVQSDTNQATPVNSQDKDVANNRGLANSAQNTPNQSATTNQATNQALVNHNNGSIVNQATPTSVQSSTPSAQNNNHTDGNTTATETVSNANNNDVVSNNTALNVPTKTNENGSGGHLTLKEIQEDVRHSSNKPELVAIAEPASNRPKKRSRRAAPADPNATPADPAAAAVGNGGEPVAITAPYTPTTDPNANNAGQNAPNEVLSFDDNGIRPSTNRSVPTVNVVNNLPGFTLINGGKVGVFSHAMVRTSMFDSGDNKNYQAQGNVIALGRIHGTDTNDHGDFNGIEKALTVNPNSELIFEFNTMTTKNGQGATNVIIKNADTNDTIAEKTVEGGPTLRLFKVPDNVRNLKIQFVPKNDAITDARGIYQLKDGYKYYSFVDSIGLHSGSHVFVERRTMDPTATNNKEFTVTTSLKNNGNSGASLDTNDFVYQVQLPEGVEYVNNSLTKDFPSNNSGVDVNDMNVTYDAANRVITIKSTGGGTANSPARLMPDKILDLRYKLRVNNVPTPRTVTFNETLTYKTYTQDFINSAAESHTVSTNPYTIDIIMNKDALQAEVDRRIQQADYTFASLDIFNGLKRRAQTILDENRNNVPLNKRVSQAYIDSLTNQMQHTLIRSVDAENAVNKKVDQMEDLVNQNDELTDEEKQAAIQVIEEHKNEIIGNIGDQTTDDGVTRIKDQGIQTLSGDTATPVVKPNAKKAIRDKATKQREIINATPDVTEDEIQDALNQLATDETDAIDNVTNATTNADVETAKNNGINTIGAVVPQVTHKKAARDAINQATATKRQQINSNREATQEEKNAALNELTQATNHALEQINQATTNADVDNAKGDGLNAINPIAPVTVVKQAARDAVSHDAQQHIAEINANPDATQEERQAAIDKVNAAVTAANTNILNANTNADVEQVKTNAIQGIQAITPATKVKTDAKNAIDKSAETQHNTIFNNNDATLEEQQAAQQLLDQAVATAKQNINAADTNQEVAQAKDQGTQNIVVIQPATQVKTDTRNVVNDKAREAITNINATTGATREEKQEAINRVNTLKNRALTDIGVTSTTAMVNSIRDDAVNQIGAVQPHVTKKQTATGVLNDLATAKKQEINQNTNATTEEKQVALNQVDQELATAINNINQADTNAEVDQAQQLGTKAINAIQPNIVKKPAALAQINQHYNAKLAEINATPDATNDEKNAAINTLNQDRQQAIESIKQANTNAEVDQAATVAENNIDAVQVDVVKKQAARDKITAEVAKRIEAVKQTPNATDEEKQAAVNQINQLKDQAINQINQNQTNDQVDTTTNQAVNAIDNVEAEVVIKPKAIADIEKAVKEKQQQIDNSLDSTDNEKEVASQALAKEKEKALAAIDQAQTNSQVNQAATNGVSAIKIIQPETKVKPAAREKINQKANELRAKINQDKEATAEERQVALDKINEFVNQAMTDITNNRTNQQVDDTTSQALDSIALVTPDHIVRAAARDAVKQQYEAKKREIEQAEHATDEEKQVALNQLANNEKRALQNIDQAIANNDVKRVETNGIATLKGVQPHIVIKPEAQQAIKASAENQVESIKDTPHATVDELDEANQLISDTLKQAQQEIENTNQDAAVTDVRNQTIKAIEQIKPKVRRKRAALDSIEENNKNQLDAIRNTLDTTQDERDVAIDTLNKIVNTIKNDIAQNKTNAEVDRTETDGNDNIKVILPKVQVKPAARQSVGVKAEAQNALIDQSDLSTEEERLAAKHLVEQALNQAIDQINHADKTAQVNQDSINAQNIISKIKPATTVKATALQQIQNIATNKINLIKANNEATDEEQNIAIAQVEKELIKAKQQIASAVTNADVAYLLHDEKNEIREIEPVINRKASAREQLTTLFNDKKQAIEANIQATVEERNSILAQLQNIYDTAIGQIDQDRSNAQVDKTASLNLQTIHDLDVHPIKKPDAEKTINDDLARVTALVQNYRKVSNRNKADALKAITALKLQMDEELKTARTNADVDAVLKRFNVALSDIEAVITEKENSLLRIDNIAQQTYAKFKAIATPEQLAKVKVLIDQYVADGNRMIDEDATLNDIKQHTQFIVDEILAIKLPAEATKVSPKEIQPAPKVCTPIKKEETHESRKVEKELPNTGSEGMDLPLKEFALITGAALLARRRTKNEKES
>NC_002951.2|WP_000836465.1|1862482_1862794_-|rhodanese-like-domain-containing-protein
MKSITTDELKNKLLESKPVQIVDVRTDEETAMGYIPNAKLIPMDTIPDNLNSFNKNEIYYIVCAGGVRSAKVVEYLEANGIDAVNVEGGMHAWGDEGLEIKSI
>NC_002951.2|WP_001549041.1|1862815_1865233_-|leucine--tRNA-ligase
MLNYNHNQIEKKWQDYWDENKTFKTNDNLGQKKFYALDMFPYPSGAGLHVGHPEGYTATDIISRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTKKNIQTFKRQIKELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPALGTVLSNEEVIDGVSERGGHPVYRKPMKQWVLKITEYADQLLADLDDLDWPESLKDMQRNWIGRSEGAKVSFDVDNTEGKVEVFTTRPDTIYGASFLVLSPEHALVNSITTDEYKEKVKAYQTEASKKSDLERTDLAKDKSGVFTGAYATNPLSGEKVQIWIADYVLSTYGTGAIMAVPAHDDRDYEFAKKFDLPIIEVIEGGNVEEAAYTGEGKHINSGELDGLENEAAITKAIQLLEQKGAGEKKVNYKLRDWLFSRQRYWGEPIPVIHWEDGTMTTVPEEELPLLLPETDEIKPSGTGESPLANIDSFVNVVDEKTGMKGRRETNTMPQWAGSCWYYLRYIDPKNENMLADPEKLKHWLPVDLYIGGVEHAVLHLLYARFWHKVLYDLAIVPTKEPFQKLFNQGMILGEGNEKMSKSKGNVINPDDIVQSHGADTLRLYEMFMGPLDAAIAWSEKGLDGSRRFLDRVWRLMVNEDGTLSSKIVTTNNKSLDKVYNQTVKKVTEDFETLGFNTAISQLMVFINECYKVDEVYKPYIEGFVKMLAPIAPHIGEELWSKLGHEESITYQPWPTYDEALLVDDEVEIVVQVNGKLRAKIKIAKDTSKEEMQEIALSNDNVKASIEGKDIMKVIAVPQKLVNIVAK
>NC_002951.2|WP_001025061.1|1865520_1866702_-|MFS-transporter
MNIPKSVWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTFTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVAVGAAMGGFVAEFSFNYIFLANLIMYVVFALVAVTQFNIEINAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWESTIASFTQSINISMAQYSVLWTINGIMILVAQPLIKPILYLLKGNLKKQMFVGIIIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPDGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMLLLVFALILLMVFKENNTQPKKIDA
>NC_002951.2|WP_000526539.1|1866811_1867765_+|TIGR01212-family-radical-SAM-protein
MGNHFQYAFENKRYHTWNYHLKNKFGQKIFKVALDGGFDCPNRDGTVAHGGCTFCSAAGSGDFAGNRADSIAVQFKEIKEKMHEKWHEGKYIAYFQAFTNTHAPVEVLKEKFEPVLKEPGVVGLSIGTRPDCLPDDVVEYLADLNQRTYLWVELGLQTIHQSTSDLINRAHDMKTYYDGVAKLRKHNINVCTHIINGLPGEDYDMMMATAKEVAQMDVQGIKIHLLHLLKGTPMVKQYDKGLLTFMTQEEYTNLVVDQLEVIPPEMIVHRITGDGPIDIMVGPMWSVNKWEVLNGIDAELARRNSYQGLRYKSKVKQ
>NC_002951.2|WP_000764419.1|1867761_1868325_+|class-I-SAM-dependent-methyltransferase
MKLERILPFSKTLIKQHITPESIVVDATCGNGNDTLFLAEQVPEGHVYGFDIQDLALENTRDKVKDFNHVSLIKDGHENIEHHINDAHKGHIDAAIFNLGYLPKGDKSIVTKPDTTIQAINSLLSLMSIEGIIVLVIYHGHSEGQIEKHALLDYLSTLDQKHAQVLQYQFLNQRNHAPFICAIEKIS

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Crispr_ID: NC_002951_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002951_9

2008860-2008938

Orphan

Consensus_repeat	Method
TGTTGGGGCCCCGCCAACCTGCA	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NC_002951_9

>merge|NC_002951|9|2008860-2008938|CRISPRCasFinder
TGTTGGGGCCCCGCCAACCTGCACATTATCGTAAGCTGACTTTTCGTCAGCTTCTGTGTTGGGGCCCCGCCAACCTGCA

>NC_002951|9|7|2008860-2008938|CRISPRCasFinder
TGTTGGGGCCCCGCCAACCTGCA	CATTATCGTAAGCTGACTTTTCGTCAGCTTCTG
TGTTGGGGCCCCGCCAACCTGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_002951.2\|WP_000149064.1\|2006599_2007301_-\|cell-wall-active-antibiotics-response-protein	unknown	unknown	gnl\|CDD\|227100
NC_002951.2\|WP_001017131.1\|2005559_2006603_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_002951.2\|WP_001250336.1\|2011992_2013306_-\|lipid-II-isoglutaminyl-synthase-subunit-MurT	unknown	unknown	gnl\|CDD\|223840
NC_002951.2\|WP_000999713.1\|2009204_2010191_+\|aromatic-acid-exporter-family-protein	unknown	unknown	gnl\|CDD\|226614
NC_002951.2\|WP_000949467.1\|2013597_2014098_+\|H-type-ferritin-FtnA	unknown	unknown	gnl\|CDD\|224445
NC_002951.2\|WP_001549145.1\|2010621_2011035_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000544969.1\|2011259_2011991_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NC_002951.2\|WP_001110179.1\|2007315_2007702_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000428172.1\|2003054_2003330_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000180461.1\|2002236_2002437_-\|DUF1128-family-protein	unknown	unknown	gnl\|CDD\|227177
NC_002951.2\|WP_000153530.1\|2004940_2005570_-\|two-component-system-response-regulator-VraR	unknown	unknown	gnl\|CDD\|225107
NC_002951.2\|WP_001795438.1\|2000977_2002234_-\|aminopeptidase	unknown	unknown	gnl\|CDD\|376723
NC_002951.2\|WP_000228666.1\|2002583_2003048_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|319971
NC_002951.2\|WP_000613733.1\|2014486_2015041_+\|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99834
NC_002951.2\|WP_001790679.1\|2014179_2014272_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000548781.1\|2016425_2016956_-\|DUF3267-domain-containing-protein	unknown	unknown	gnl\|CDD\|378690
NC_002951.2\|WP_000636142.1\|2007918_2008677_-\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
NC_002951.2\|WP_000037073.1\|2003607_2004825_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|224214
NC_002951.2\|WP_000140176.1\|2015108_2016179_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035
NC_002951.2\|WP_001790257.1\|2011063_2011174_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_002951.2\|WP_000149064.1\|2006599_2007301_-\|cell-wall-active-antibiotics-response-protein	gnl\|CDD\|227100	COG4758, COG4758, Predicted membrane protein [Function unknown].	9.42019e-79
NC_002951.2\|WP_001017131.1\|2005559_2006603_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.78722e-72
NC_002951.2\|WP_000999713.1\|2009204_2010191_+\|aromatic-acid-exporter-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	6.20478e-76
NC_002951.2\|WP_000544969.1\|2011259_2011991_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	3.33663e-121
NC_002951.2\|WP_000949467.1\|2013597_2014098_+\|H-type-ferritin-FtnA	gnl\|CDD\|224445	COG1528, Ftn, Ferritin-like protein [Inorganic ion transport and metabolism].	4.6035e-74
NC_002951.2\|WP_000548781.1\|2016425_2016956_-\|DUF3267-domain-containing-protein	gnl\|CDD\|378690	pfam11667, DUF3267, Putative zincin peptidase. This family of proteins has a conserved HEXXH motif, suggesting the members are putative peptidases of zincin fold.	1.4991e-11
NC_002951.2\|WP_000180461.1\|2002236_2002437_-\|DUF1128-family-protein	gnl\|CDD\|227177	COG4840, COG4840, Uncharacterized protein conserved in bacteria [Function unknown].	2.44511e-24
NC_002951.2\|WP_000153530.1\|2004940_2005570_-\|two-component-system-response-regulator-VraR	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.91794e-79
NC_002951.2\|WP_001795438.1\|2000977_2002234_-\|aminopeptidase	gnl\|CDD\|376723	pfam02073, Peptidase_M29, Thermophilic metalloprotease (M29).	0
NC_002951.2\|WP_000228666.1\|2002583_2003048_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	3.39151e-65
NC_002951.2\|WP_000613733.1\|2014486_2015041_+\|3'-5'-exonuclease	gnl\|CDD\|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	1.92778e-75
NC_002951.2\|WP_000636142.1\|2007918_2008677_-\|type-I-methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	1.9498e-126
NC_002951.2\|WP_000037073.1\|2003607_2004825_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|224214	COG1295, Rbn, Ribonuclease BN family enzyme [Replication, recombination, and repair].	4.1146e-85
NC_002951.2\|WP_000140176.1\|2015108_2016179_-\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
NC_002951.2\|WP_001250336.1\|2011992_2013306_-\|lipid-II-isoglutaminyl-synthase-subunit-MurT	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	7.18737e-99

>NC_002951.2|WP_000636142.1|2007918_2008677_-|type-I-methionyl-aminopeptidase
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKIEEE
>NC_002951.2|WP_001110179.1|2007315_2007702_-|hypothetical-protein
MNYVERYIEQFLRATVRNNIKHYLLMLDEKMKNLDDYMRYLITKKEQLSKLIDSLMLTLENKYIDIAEAFQIQCAREINNQEIENIKSELNKVEAYYAQIETQIQQTSTEKIATEKTSYLINYMNAVA
>NC_002951.2|WP_000149064.1|2006599_2007301_-|cell-wall-active-antibiotics-response-protein
MTHKYISTQMLIIFTALMIIANFYYIFFEKIGFLLVLLLGCVLVYVGYLYFHKIRGLLAFWIGALLIAFTLLSNKYTIIILFVFLLLLIVRYLIHKFKPKKVVATDEVMTSPSFIKQKWFGEQRTPVYVYKWEDVQIQHGIGDLHIDLTKAANIKENNTIVVRHILGKVQVILPVNYNINLHVAAFYGSTYVNEKSYKVENNNIHIEEMMKPDNYTVNIYVSTFIGDVEVIYR
>NC_002951.2|WP_001017131.1|2005559_2006603_-|sensor-histidine-kinase
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKTQIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVSQQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEIQDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGATFHIVSLPDSGTRIEVKAPLNKEDSYDD
>NC_002951.2|WP_000153530.1|2004940_2005570_-|two-component-system-response-regulator-VraR
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVLMLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIAKGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
>NC_002951.2|WP_000037073.1|2003607_2004825_+|YihY/virulence-factor-BrkB-family-protein
MSKKDHSSSKYLNSVKEAQEESKKKNKSNPKIDVDRTYIEPQQFQSKKPKKDDQVFFLSRLNKPAKYKKDSNFLSYLIYRIGKDDASGLAAQMTYHFVLAMFPMLLFLLTLLPFFNIKQSQITNMLSNAPAETSTLIKSVIGDITQNSSGGLLSIGLILAIWSASNGMTAIMNSFNVAYDVEDSRNGIVLKLLSVVFTVVMGVVFVVALALPTLGSVISHFLFGPLGFDEQVKWIFNLIRIVLPIIIIFIIFIVLYSVAPNVKTKLKSVLPGAVFTSIIWLAGSFGFGWYISNFGNYSKTYGSIAGIIILLLWLYITSFIIIVGAEINAIIHQRSVIKGKTPEEAALEHDDNNKNHYNENTRYEYDDDSNATHQRTYHVDEHPSDTYPEDDKNIKDKIVDKLKKD
>NC_002951.2|WP_000428172.1|2003054_2003330_+|hypothetical-protein
MENKFVPGILIGAVIGGAISLADKSTRQALVQSVKDAKNGNRTRKPSKVSKIKDEVLYWKDVVEEIRRNNPELERSLKDAKETFVNRKNQR
>NC_002951.2|WP_000228666.1|2002583_2003048_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIHDIKVHSRGTGSWNLGEPPHEGTQKILNKHNIPFDGMISELFEATDDFDYIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPDPYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG
>NC_002951.2|WP_000180461.1|2002236_2002437_-|DUF1128-family-protein
MTNEEKVLAIREKLNIVNQGLLDPEKYKNANEEELTDIYDFVQSRERLSPSEVTAIADALGQLRHE
>NC_002951.2|WP_001795438.1|2000977_2002234_-|aminopeptidase
MGILTNYKEKLQQYAELLVKVGMNVQPKQPVFIRSSVETLELTHLIVEEAYHCGASDVRVVYSDPTLKRLKFENESVEHFANHEIKSYDVEARMDYVKRGAANLALISEDPDLMDGIDSQKLQAFQQQNARAFKGYMESVQKNQFPWVVAAFPSKAWAKRVYPELSVEEAYIKFIDEVFDIVRIDGNDPVENWRQHIANLSVYAQKLQQKNYHALHYVSEGTDLTVGLAKNHIWEDATSYVNGKEQAFIANIPTEEVFTAPDRNRVDGYVTNKLPLSYNGTIIDQFKLMFKDGEIIDFSAGKGEAVLKDLINTDEGSRRLGEVALVPDDSPISNRNTIFYNTLFDENAACHLAIGSAYAFNIQGGTEMTVEEKIASGLNDSNVHVDFMIGSSDLTIYGIFEDGSKELVFENGNWASTF
>NC_002951.2|WP_000999713.1|2009204_2010191_+|aromatic-acid-exporter-family-protein
MNDQWYKHLIGARTIKTGIAIFLTAVFCMALDLTPIYAILTAVVTIEPTAKASLIKGYRRLPATVIGAGFAVLFTYLFGDQSPFTYALSATFTILFCTKLKLQVGTNVAVLTSLAMIPGIHDAYIFNFLSRTLTAIIGLVTSGLINFMVFPPKYYGQVEEKLSKTDALMYKLFYNRCQELILSRLQSDKSEKAYKNIFNLNNQVETLISYQRDELSYHKKKECDWKLLNQLTKRAYTNRLFITHLSNIIYLPKNTRVNFSGDEKMALLKISSSIKDIFYDGSFKREDDSVETLRSTIKALEISGENQIKSHILYEVLMIYRLLDSRYA
>NC_002951.2|WP_001549145.1|2010621_2011035_-|hypothetical-protein
MKPTKVILKDASYLHSKTSITFILKDVVIEEDNKIYYFDTSATFEDQEVKFEFALFDSDMDNLKHMDCDNPVTEIYFIEPDLHFTIIDFNQELLCIYIDFDSGLRHSNMATESGISLRINVAKSDFTKFINELASLH
>NC_002951.2|WP_001790257.1|2011063_2011174_-|hypothetical-protein
MDGNNQIDVCFFVLVNNYYTMSIYPRIINSNGDYAT
>NC_002951.2|WP_000544969.1|2011259_2011991_-|type-1-glutamine-amidotransferase
MHELTIYHFMSDKLNLYSDIGNIIALRQRAKKRNIKVNVVEINETEGITFDECDIFFIGGGSDREQALATKELSKIKTPLKEAIEDGMPGLTICGGYQFLGKKYITPDGTELEGLGILDFYTESKTNRLTGDIVIESDTFGTIVGFENHGGRTYHDFGTLGHVTFGYGNNDEDKKEGIHYKNLLGTYLHGPILPKNYEITDYLLEKACERKGIPFEPKEIDNEAEIQAKQVLIDRANRQKKSR
>NC_002951.2|WP_001250336.1|2011992_2013306_-|lipid-II-isoglutaminyl-synthase-subunit-MurT
MRQWTAIHLAKLARKASRAVGKRGTDLPGQIARKVDTDILRKLAEQVDDIVFISGTNGKTTTSNLIGHTLKANNIQIIHNNEGANMAAGITSAFIMQSTPKTKIAVIEIDEGSIPRVLKEVTPSMMVFTNFFRDQMDRFGEIDIMVNNIAETISNKGIKLLLNADDPFVSRLKIASDTIVYYGMKAHAHEFEQSTMNESRYCPNCGRLLQYDYIHYNQIGHYHCQCGFKREQAKYEISSFDVAPFLYLNINDEKYDMKIAGDFNAYNALAAYTVLRELGLNEQTIKNGFETYTSDNGRMQYFKKERKEAMINLAKNPAGMNASLSVGEQLEGEKVYVISLNDNAADGRDTSWIYDADFEKLSKQQIEAIIVTGTRAEELQLRLKLAEVEVPIIVERDIYKATAKTMDYKGFTVAIPNYTSLAPMLEQLNRSFEGGQS
>NC_002951.2|WP_000949467.1|2013597_2014098_+|H-type-ferritin-FtnA
MLSKNLLEALNDQMNHEYFAAHAYMAMAAYCDKESYEGFANFFIQQAKEERFHGQKIYNYINDRGAHAEFRAVSAPKIDFSSILETFKDSLSQEQEVTRRFYNLSEIARQDKDYATISFLNWFLDEQVEEESMFETHINYLTRIGDDSNALYLYEKELGARTFDEE
>NC_002951.2|WP_001790679.1|2014179_2014272_-|hypothetical-protein
MTKNTIISLENEKTQINDSENESSDLRKAK
>NC_002951.2|WP_000613733.1|2014486_2015041_+|3'-5'-exonuclease
MIQDAFVALDFETANGKRTSICSVGMVKVIDSQITETFHTLVNPQDYFSQQNIKIHGIQPEDVENAPTFDYVFPYMMQFIADLPVVAHNAAFDMNVLHQSIQNIGLPTPNLTYFCSYQLAKRTVDSYRYGLKHMMEFYQLDFHGHHDALNDAKACAMITFRLLKNYENLTYVTNIYGKNLKDKG
>NC_002951.2|WP_000140176.1|2015108_2016179_-|DNA-polymerase-IV
MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGMTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTYKNMTIYDFI
>NC_002951.2|WP_000548781.1|2016425_2016956_-|DUF3267-domain-containing-protein
MHKIDLTTNNFQMRRFIILQLVIALFVILFTYKWALGVTAVVDQNIIINLVYGFAGFIILLILHELIHRALFLLFKKDSKPMFNIKKDRILFQTADACFNKWQFSIIMLSPLILLSTGLLILIKVFGYSSLIFMFSMHTAYCFIDILLVALTISSSFKYVQQDEDSIYLYHQKPTQ

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Crispr_ID: NC_002951_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002951_10

2200955-2201035

Orphan

Consensus_repeat	Method
TTACAACTTTAGTTGTTAGGGGCT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_002951_10

>merge|NC_002951|10|2200955-2201035|CRISPRCasFinder
TTACAACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTACTTTTAAACTTTAGTTGTTAGGGGCT

>NC_002951|10|8|2200955-2201035|CRISPRCasFinder
TTACAACTTTAGTTGTTAGGGGCT	CTTATGCATGCGCTTAGCGCAGGCGCTCCTACT
TTTAAACTTTAGTTGTTAGGGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_002951.2\|WP_033841791.1\|2204387_2205245_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NC_002951.2\|WP_001292149.1\|2212529_2212964_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NC_002951.2\|WP_001127960.1\|2196091_2197030_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NC_002951.2\|WP_001802298.1\|2201374_2201479_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_001123303.1\|2192914_2193328_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NC_002951.2\|WP_000908177.1\|2205312_2206095_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_002951.2\|WP_000070866.1\|2192271_2192715_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NC_002951.2\|WP_000495671.1\|2199849_2200941_+\|lytic-regulatory-protein	unknown	unknown	unknown
NC_002951.2\|WP_000115564.1\|2202165_2203302_-\|SAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|366887
NC_002951.2\|WP_000123393.1\|2193785_2195159_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NC_002951.2\|WP_000019744.1\|2198603_2199584_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NC_002951.2\|WP_000808817.1\|2195830_2196061_-\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000648718.1\|2212963_2214070_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NC_002951.2\|WP_000003759.1\|2198281_2198602_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_002951.2\|WP_000927363.1\|2210385_2212518_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_002951.2\|WP_000083809.1\|2208812_2210351_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NC_002951.2\|WP_000334465.1\|2206326_2208132_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_002951.2\|WP_000160304.1\|2191440_2192151_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_002951.2\|WP_001790138.1\|2203590_2203683_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_001024094.1\|2197464_2198130_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554

Protein	Function_ID	Function_description	E-value
NC_002951.2\|WP_033841791.1\|2204387_2205245_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.03041e-58
NC_002951.2\|WP_001292149.1\|2212529_2212964_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
NC_002951.2\|WP_001127960.1\|2196091_2197030_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	7.24075e-129
NC_002951.2\|WP_000019744.1\|2198603_2199584_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.049e-108
NC_002951.2\|WP_001123303.1\|2192914_2193328_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	3.14887e-46
NC_002951.2\|WP_000070866.1\|2192271_2192715_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	1.22744e-67
NC_002951.2\|WP_000334465.1\|2206326_2208132_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_002951.2\|WP_000648718.1\|2212963_2214070_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NC_002951.2\|WP_000115564.1\|2202165_2203302_-\|SAP-domain-containing-protein	gnl\|CDD\|366887	pfam02037, SAP, SAP domain. The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.	3.91533e-06
NC_002951.2\|WP_000123393.1\|2193785_2195159_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.86989e-06
NC_002951.2\|WP_000083809.1\|2208812_2210351_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NC_002951.2\|WP_000003759.1\|2198281_2198602_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
NC_002951.2\|WP_000927363.1\|2210385_2212518_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	4.09729e-67
NC_002951.2\|WP_001024094.1\|2197464_2198130_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.74381e-48
NC_002951.2\|WP_000908177.1\|2205312_2206095_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	9.86955e-104
NC_002951.2\|WP_000160304.1\|2191440_2192151_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157

>NC_002951.2|WP_000495671.1|2199849_2200941_+|lytic-regulatory-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYAQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NC_002951.2|WP_000019744.1|2198603_2199584_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALVAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHVH
>NC_002951.2|WP_000003759.1|2198281_2198602_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NC_002951.2|WP_001024094.1|2197464_2198130_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFDGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGDQDIKDALTQFENETD
>NC_002951.2|WP_001127960.1|2196091_2197030_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>NC_002951.2|WP_000808817.1|2195830_2196061_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>NC_002951.2|WP_000123393.1|2193785_2195159_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRISNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NC_002951.2|WP_001123303.1|2192914_2193328_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIKLITALPNRTKLLGVGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NC_002951.2|WP_000070866.1|2192271_2192715_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLENAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NC_002951.2|WP_000160304.1|2191440_2192151_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NC_002951.2|WP_001802298.1|2201374_2201479_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NC_002951.2|WP_000115564.1|2202165_2203302_-|SAP-domain-containing-protein
MSVNARDLLVLHTNVNRLVGEEIFANKCLANNDVQIMNSIKKLIEAELLTTTNDFEVSIYKKTRPELQSILKSFGIKTTGNKPDLIKRIDDNFHIINNLDLPYVYIPTKKGEEILKKTEYLTSFIQSYGEISLERAYYLVENYIDENCDDKVAEIYKFEFQRKYDNGEFDFNHGYNFELNMLIDHYKRDVKDYDNARKYSNIYLYFGLRDFLKKLMSNYSYYDSKGNIDLNEIQNDLNRFINSSASGMYERLIYNENLSNNIMFELFKKDTQDYSDLEEQLIEKFINYVVSNVKKESRSNTLIELSKILENGYTIDKEEFKKEDDYLSKYIFTDIDYLKKLESKINVAIDIRSGEIHLVLDDDSLDILIQNQKYGNEF
>NC_002951.2|WP_001790138.1|2203590_2203683_+|hypothetical-protein
MFIFKTTSKSHFHNNVKSLECIKIPINKNR
>NC_002951.2|WP_033841791.1|2204387_2205245_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINQLREKGYKVFLATGRSHSEIHQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQITNLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRYELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAEHFLAE
>NC_002951.2|WP_000908177.1|2205312_2206095_-|ABC-transporter-ATP-binding-protein
MLIQLDQIGRMKQGKTILKKISWQIAKGDKWILYGLNGAGKTTLLNILNAYEPATSGTVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEIRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITANFSKILLLKDGQSIQQGAVEDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NC_002951.2|WP_000334465.1|2206326_2208132_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>NC_002951.2|WP_000083809.1|2208812_2210351_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKTTSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NC_002951.2|WP_000927363.1|2210385_2212518_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGTDSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVNKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHVETKDVDGNTSFENEQTSYLTSVFEKHLSDEKSEQLLHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFISDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NC_002951.2|WP_001292149.1|2212529_2212964_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
>NC_002951.2|WP_000648718.1|2212963_2214070_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVEDSSIEAGLRRVLAETSQYITNEFDFTEAEQAAYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS

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Crispr_ID: NC_002951_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_002951_11

2325056-2325249

Orphan

Consensus_repeat	Method
TGTTGGGGCCCCGCCAACTTGCA	CRT

3 spacers

The CRISPR arrays of NC_002951_11

>merge|NC_002951|11|2325056-2325249|CRT
TGTTGGGGCCCCGCCAACTTGCACATTATTGTATGCTGACTTTTCGTCACCTTCTGTGTTGGGGCCCCGTTCCCCAACTTGCATTGTCTGTAGAATTTCTTTTTGAAATTCTCTATGTTGGGGCCCCGCCAACTTGCACATTATTGTAAGCTGACTTTCTGTCAGCTTCTGTGTTGGGGCCCCGCCAACTTGTA

>NC_002951|11|3|2325056-2325249|CRT
TGTTGGGGCCCCGCCAACTTGCA	CATTATTGTATGCTGACTTTTCGTCACCTTCTG
TGTTGGGGCCCCGTTCCCCAACT	TGCATTGTCTGTAGAATTTCTTTTTGAAATTCTCTA
TGTTGGGGCCCCGCCAACTTGCA	CATTATTGTAAGCTGACTTTCTGTCAGCTTCTG
TGTTGGGGCCCCGCCAACTTGTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_002951.2\|WP_000866971.1\|2327038_2327272_-\|molybdopterin-converting-factor-subunit-1	unknown	unknown	gnl\|CDD\|340452
NC_002951.2\|WP_000259718.1\|2328219_2329479_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NC_002951.2\|WP_000600959.1\|2321677_2322442_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|379203
NC_002951.2\|WP_000413868.1\|2319780_2321046_-\|lipid-II:glycine-glycyltransferase-FemX	unknown	unknown	gnl\|CDD\|225224
NC_002951.2\|WP_000643988.1\|2326432_2327032_-\|molybdenum-cofactor-guanylyltransferase-MobA	unknown	unknown	gnl\|CDD\|234725
NC_002951.2\|WP_000134528.1\|2329541_2330036_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
NC_002951.2\|WP_000592303.1\|2316496_2319664_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NC_002951.2\|WP_000951058.1\|2322603_2323044_+\|winged-helix-DNA-binding-protein	unknown	unknown	gnl\|CDD\|197670
NC_002951.2\|WP_000184419.1\|2323036_2324248_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NC_002951.2\|WP_001549681.1\|2321434_2321686_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000602937.1\|2327737_2328223_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	unknown	unknown	gnl\|CDD\|224677
NC_002951.2\|WP_000051206.1\|2315583_2315748_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000503820.1\|2330037_2330544_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	unknown	unknown	gnl\|CDD\|223595
NC_002951.2\|WP_000076929.1\|2330574_2331579_-\|ThiF-family-adenylyltransferase	unknown	unknown	gnl\|CDD\|181084
NC_002951.2\|WP_001161085.1\|2315992_2316310_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000808500.1\|2327277_2327724_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|223391
NC_002951.2\|WP_000913019.1\|2331748_2332354_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226628
NC_002951.2\|WP_000066900.1\|2324349_2324700_-\|HTH-type-transcriptional-regulator-SarV	unknown	unknown	gnl\|CDD\|130944
NC_002951.2\|WP_001790034.1\|2324825_2324996_+\|hypothetical-protein	unknown	unknown	unknown
NC_002951.2\|WP_000230173.1\|2325390_2326413_-\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|274250

Protein	Function_ID	Function_description	E-value
NC_002951.2\|WP_000866971.1\|2327038_2327272_-\|molybdopterin-converting-factor-subunit-1	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	8.16473e-25
NC_002951.2\|WP_000600959.1\|2321677_2322442_-\|VOC-family-protein	gnl\|CDD\|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	6.20256e-38
NC_002951.2\|WP_000413868.1\|2319780_2321046_-\|lipid-II:glycine-glycyltransferase-FemX	gnl\|CDD\|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	2.65808e-142
NC_002951.2\|WP_000951058.1\|2322603_2323044_+\|winged-helix-DNA-binding-protein	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.35323e-15
NC_002951.2\|WP_000134528.1\|2329541_2330036_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	3.63862e-98
NC_002951.2\|WP_000592303.1\|2316496_2319664_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NC_002951.2\|WP_000643988.1\|2326432_2327032_-\|molybdenum-cofactor-guanylyltransferase-MobA	gnl\|CDD\|234725	PRK00317, mobA, molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed.	5.68918e-67
NC_002951.2\|WP_000230173.1\|2325390_2326413_-\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|274250	TIGR02666, Cyclic_pyranopterin_monophosphate_synthase, molybdenum cofactor biosynthesis protein A, bacterial. The model for this family describes molybdenum cofactor biosynthesis protein A, or MoaA, as found in bacteria. It does not include the family of probable functional equivalent proteins from the archaea. MoaA works together with MoaC to synthesize precursor Z from guanine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin].	1.0538e-165
NC_002951.2\|WP_000184419.1\|2323036_2324248_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.27961e-72
NC_002951.2\|WP_000602937.1\|2327737_2328223_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	gnl\|CDD\|224677	COG1763, MobB, Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism].	4.35501e-50
NC_002951.2\|WP_000503820.1\|2330037_2330544_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	gnl\|CDD\|223595	COG0521, MoaB, Molybdopterin biosynthesis enzymes [Coenzyme metabolism].	9.7838e-65
NC_002951.2\|WP_000076929.1\|2330574_2331579_-\|ThiF-family-adenylyltransferase	gnl\|CDD\|181084	PRK07688, PRK07688, thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated.	3.67241e-132
NC_002951.2\|WP_000259718.1\|2328219_2329479_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	9.49423e-160
NC_002951.2\|WP_000913019.1\|2331748_2332354_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226628	COG4148, ModC, ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism].	3.32197e-115
NC_002951.2\|WP_000066900.1\|2324349_2324700_-\|HTH-type-transcriptional-regulator-SarV	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	2.64009e-20
NC_002951.2\|WP_000808500.1\|2327277_2327724_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|223391	COG0314, MoaE, Molybdopterin converting factor, large subunit [Coenzyme metabolism].	5.56799e-58

>NC_002951.2|WP_001790034.1|2324825_2324996_+|hypothetical-protein
MFRFISFGQLVVYSTTFIPKKDILQLNGMECDINVKEPLKIYYVVILKSGIEMIFS
>NC_002951.2|WP_000066900.1|2324349_2324700_-|HTH-type-transcriptional-regulator-SarV
MSNKVQRFIEAERELSQLKHWLKTTHKISIEEFVVLFKVYEAEKISGKELRDTLHFEMLWDTSKIDVIIRKIYKKELISKLRSETDERQVFYFYSTSQKKLLDKITKEIEVLSVTN
>NC_002951.2|WP_000184419.1|2323036_2324248_+|MFS-transporter
MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLFIVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAVVTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILGILGLIISLFIKVDFEVTNNKTETNVIDKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILTYLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCLISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPSFLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
>NC_002951.2|WP_000951058.1|2322603_2323044_+|winged-helix-DNA-binding-protein
MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEKPTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNISQDQMQETINVMNQIHEILLKEAHND
>NC_002951.2|WP_000600959.1|2321677_2322442_-|VOC-family-protein
MILKFDHIIHYIDQLDRFSFPGDVIKLHSGGYHHKYGTFNKLGYINENYIELLDVENNEKLKKMAKTIEGGVAFATQIVQEKYEQGFKNICLHTNDIEAVKNKLQSEQVEVVGPIQMERDTHKDGKVKWQLLYIMNQDDDEIKPPFFIQWEESDSMRTKKLQKYFQKQFSIETVIVKSKNRSQTVSNWLKWFDMDIVEENDHYTDLILKNDDIYFRIEDGKVSKYHSVIIKDAQATSPYSIFIRGAIYRFEPLV
>NC_002951.2|WP_001549681.1|2321434_2321686_+|hypothetical-protein
MRTIILSLFIIMNIVAIIMTLSQPLTVNYFSLRVILIFFTFILSIFFILIKSSRLNNILTILSIVLVIIHMGILAHSTYVYLY
>NC_002951.2|WP_000413868.1|2319780_2321046_-|lipid-II:glycine-glycyltransferase-FemX
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEVQGVAQLLFKKVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKTYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIAKVNQELNELHAEIAKWQQKMKTSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLIEQVKPRLTKAKIKISRKLKRK
>NC_002951.2|WP_000592303.1|2316496_2319664_-|efflux-RND-transporter-permease-subunit
MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIKFKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIPLTLAGGQGQSQSQSDNKQNSAMSDVNQASPQQNSKASAPNNISGMPTAKLGDLADITVGDVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFVDENKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGVVSTTYKKVLHWSLNHKWIVIILSTLILVATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSSPVDPTGSTNSMAIMVEYDNDTPNFDVEADKVIKHADGFKHPGEWKNQDLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKRFTKR
>NC_002951.2|WP_001161085.1|2315992_2316310_+|hypothetical-protein
MQFYLILLAILYLIVSFISIFKMEVVFTRILRIIMGVLLLFVLALTTMSFPKENWWVFIVLLLLVGNVEVTGFKMLKKDLKGVNILNLMSLFIFVIYFILTIVLF
>NC_002951.2|WP_000051206.1|2315583_2315748_+|hypothetical-protein
MSLENQLAELKYDYVRLQGDIEKRESLNLDTSALVRQLKDIENEIRNVRAQMQD
>NC_002951.2|WP_000230173.1|2325390_2326413_-|GTP-3',8-cyclase-MoaA
MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
>NC_002951.2|WP_000643988.1|2326432_2327032_-|molybdenum-cofactor-guanylyltransferase-MobA
MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYPNVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIENHLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNVYHELSTDYLDVRDVDAPSYWYKNINYQHDLDALIQKL
>NC_002951.2|WP_000866971.1|2327038_2327272_-|molybdopterin-converting-factor-subunit-1
MKVLYFAEIKDILQKAQEDIVLEQALTVQQFEDLLFERYPQINNKKFQVAVNEEFVQKSDFIQPNDTVALIPPVSGG
>NC_002951.2|WP_000808500.1|2327277_2327724_-|molybdenum-cofactor-biosynthesis-protein-MoaE
MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE
>NC_002951.2|WP_000602937.1|2327737_2328223_-|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B
MILQIVGYKKSGKTTLMRHIVSFLKSHGYTVATIKHHGHGKEDIQLQDSDVDHMKHFEAGADQSIVQGFQYQQTVTRVDNQNLTQIIEKSVTIDTNIVLVEGFKNADFEKVVVYRNEEELQVLQQLSNVCYSINVREHEDFTAFEQWLLNKIKNDCDTQLT
>NC_002951.2|WP_000259718.1|2328219_2329479_-|molybdopterin-molybdotransferase-MoeA
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETKTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQKDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFVDGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
>NC_002951.2|WP_000134528.1|2329541_2330036_+|cyclic-pyranopterin-monophosphate-synthase-MoaC
MTEFTHINQQGHAKMVDVSDKQITKRTAVAHSSITVNETIFKQISNNTNTKGNVLNTAQIAGIMAAKNTSTLIPMCHPLPLTGIDVHFSWDETNAPLYTLNIQTTVSTTGKTGVEMEALTAASATALTIYDMTKAVDKGMIIGETYLESKSGGKSGDFQRQSNQ
>NC_002951.2|WP_000503820.1|2330037_2330544_-|molybdenum-cofactor-biosynthesis-protein-MoaB
MGEHQNVKLNRTVKAAVLTVSDTRDFDTDKGGQCVRQLLQADDVEVSDAHYTIVKDEKVAITTQVKKWLEEDIDVIITTGGTGIAQRDVTIEAVKPLLTKEIEGFGELFRYLSYVEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIKPELNHLIHELTK
>NC_002951.2|WP_000076929.1|2330574_2331579_-|ThiF-family-adenylyltransferase
MSQERYSRQILFKQIGEIGQSKINQKCALIIGMGALGTHVAEGLVRAGIAKLIIVDRDYIEFSNLQRQTLFTEEDALKMMPKVVAAKKHLLALRSDVDIDDYIAHVDYYFLETHGQDVDVIIDATDNFETRQLINDFAYKYRIPWIYGGVVQSTYTEAAFIPGKTPCFNCLVPQLPALNLTCDTVGVIQPAVTMATSLQLRDAMKVLTEQPIDTKITYGDIWEGSHYSFGFSKMQRSDCTTCGDVPSYPYLNKNEQRYATLCGRDTVQYENASITHDILVQFLKQHQLNYRSNSYMVMFEFKGHRIVAFKGGRFLIHGMTRTSDATHLMNLLFG
>NC_002951.2|WP_000913019.1|2331748_2332354_-|ATP-binding-cassette-domain-containing-protein
MLKINVKYQLKNTLIRINIDDTEPKIYAVRGPSGIGKTTVLNMIAGLRKADEAIIEVNGQLLTDTAKNVNVKIQQRRIGYLFQDYQLFPNMTVYKNITFMAEPSEHIDQLIQTLNIDHLMKQYPMTLSGGEAQRVALARALSTKPDLILLDEPFSSLDDTTKDESITLVKRIFNEWQIPIIFVTHSNYEAEQMAHEIITIG

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_002951_4	4.1\|850701\|29\|NC_002951\|CRISPRCasFinder	850701-850729	29	NC_002951.2	2766975-2767003	0	1.0
NC_002951_5	5.1\|899257\|34\|NC_002951\|CRISPRCasFinder	899257-899290	34	NC_002951.2	1390526-1390559	0	1.0
NC_002951_5	5.1\|899257\|34\|NC_002951\|CRISPRCasFinder	899257-899290	34	NC_002951.2	1478971-1479004	0	1.0
NC_002951_7	7.2\|1182264\|37\|NC_002951\|CRT	1182264-1182300	37	NC_002951.2	418827-418863	0	1.0
NC_002951_7	7.2\|1182264\|37\|NC_002951\|CRT	1182264-1182300	37	NC_002951.2	1081408-1081444	0	1.0
NC_002951_7	7.2\|1182264\|37\|NC_002951\|CRT	1182264-1182300	37	NC_002951.2	1390485-1390521	0	1.0
NC_002951_7	7.3\|1182320\|37\|NC_002951\|CRT	1182320-1182356	37	NC_002951.2	149328-149364	0	1.0
NC_002951_7	7.3\|1182320\|37\|NC_002951\|CRT	1182320-1182356	37	NC_002951.2	692582-692618	0	1.0
NC_002951_7	7.3\|1182320\|37\|NC_002951\|CRT	1182320-1182356	37	NC_002951.2	808641-808677	0	1.0
NC_002951_7	7.3\|1182320\|37\|NC_002951\|CRT	1182320-1182356	37	NC_002951.2	809611-809647	0	1.0
NC_002951_7	7.3\|1182320\|37\|NC_002951\|CRT	1182320-1182356	37	NC_002951.2	1390543-1390579	0	1.0
NC_002951_7	7.3\|1182320\|37\|NC_002951\|CRT	1182320-1182356	37	NC_002951.2	1478951-1478987	0	1.0
NC_002951_7	7.3\|1182320\|37\|NC_002951\|CRT	1182320-1182356	37	NC_002951.2	2010332-2010368	0	1.0
NC_002951_4	4.1\|850701\|29\|NC_002951\|CRISPRCasFinder	850701-850729	29	NC_002951.2	418944-418972	1	0.966
NC_002951_4	4.1\|850701\|29\|NC_002951\|CRISPRCasFinder	850701-850729	29	NC_002951.2	418999-419027	1	0.966
NC_002951_4	4.1\|850701\|29\|NC_002951\|CRISPRCasFinder	850701-850729	29	NC_002951.2	1850370-1850398	1	0.966
NC_002951_6	6.1\|964053\|26\|NC_002951\|CRT	964053-964078	26	NC_002951.2	963997-964022	1	0.962
NC_002951_7	7.1\|1182208\|37\|NC_002951\|CRT	1182208-1182244	37	NC_002951.2	1850367-1850403	1	0.973
NC_002951_7	7.2\|1182264\|37\|NC_002951\|CRT	1182264-1182300	37	NC_002951.2	1479009-1479045	1	0.973
NC_002951_7	7.2\|1182264\|37\|NC_002951\|CRT	1182264-1182300	37	NC_002951.2	1671706-1671742	1	0.973
NC_002951_7	7.2\|1182264\|37\|NC_002951\|CRT	1182264-1182300	37	NC_002951.2	2601571-2601607	1	0.973
NC_002951_7	7.3\|1182320\|37\|NC_002951\|CRT	1182320-1182356	37	NC_002951.2	1107668-1107704	1	0.973
NC_002951_7	7.3\|1182320\|37\|NC_002951\|CRT	1182320-1182356	37	NC_002951.2	2491618-2491654	1	0.973
NC_002951_9	9.1\|2008883\|33\|NC_002951\|CRISPRCasFinder	2008883-2008915	33	NC_002951.2	1390481-1390513	1	0.97
NC_002951_9	9.1\|2008883\|33\|NC_002951\|CRISPRCasFinder	2008883-2008915	33	NC_002951.2	1671714-1671746	1	0.97
NC_002951_9	9.1\|2008883\|33\|NC_002951\|CRISPRCasFinder	2008883-2008915	33	NC_002951.2	2601579-2601611	1	0.97
NC_002951_11	11.2\|2325135\|36\|NC_002951\|CRT	2325135-2325170	36	NC_002951.2	1850363-1850398	1	0.972
NC_002951_4	4.1\|850701\|29\|NC_002951\|CRISPRCasFinder	850701-850729	29	NC_002951.2	899299-899327	2	0.931
NC_002951_4	4.1\|850701\|29\|NC_002951\|CRISPRCasFinder	850701-850729	29	NC_002951.2	983692-983720	2	0.931
NC_002951_4	4.1\|850701\|29\|NC_002951\|CRISPRCasFinder	850701-850729	29	NC_002951.2	1671653-1671681	2	0.931
NC_002951_4	4.1\|850701\|29\|NC_002951\|CRISPRCasFinder	850701-850729	29	NC_002951.2	2019627-2019655	2	0.931
NC_002951_4	4.1\|850701\|29\|NC_002951\|CRISPRCasFinder	850701-850729	29	NC_002951.2	2516905-2516933	2	0.931
NC_002951_6	6.1\|964053\|26\|NC_002951\|CRT	964053-964078	26	NC_002951.2	819095-819120	2	0.923
NC_002951_6	6.1\|964053\|26\|NC_002951\|CRT	964053-964078	26	NC_002951.2	1182359-1182384	2	0.923
NC_002951_6	6.1\|964053\|26\|NC_002951\|CRT	964053-964078	26	NC_002951.2	2766943-2766968	2	0.923
NC_002951_6	6.3\|964167\|26\|NC_002951\|CRT	964167-964192	26	NC_002951.2	418810-418835	2	0.923
NC_002951_7	7.1\|1182208\|37\|NC_002951\|CRT	1182208-1182244	37	NC_002951.2	899294-899330	2	0.946
NC_002951_7	7.1\|1182208\|37\|NC_002951\|CRT	1182208-1182244	37	NC_002951.2	1671648-1671684	2	0.946
NC_002951_7	7.1\|1182208\|37\|NC_002951\|CRT	1182208-1182244	37	NC_002951.2	2019622-2019658	2	0.946
NC_002951_7	7.1\|1182208\|37\|NC_002951\|CRT	1182208-1182244	37	NC_002951.2	2516902-2516938	2	0.946
NC_002951_7	7.1\|1182208\|37\|NC_002951\|CRT	1182208-1182244	37	NC_002951.2	2766970-2767006	2	0.946
NC_002951_7	7.2\|1182264\|37\|NC_002951\|CRT	1182264-1182300	37	NC_002951.2	856075-856111	2	0.946
NC_002951_7	7.2\|1182264\|37\|NC_002951\|CRT	1182264-1182300	37	NC_002951.2	1178296-1178332	2	0.946
NC_002951_7	7.2\|1182264\|37\|NC_002951\|CRT	1182264-1182300	37	NC_002951.2	1182376-1182412	2	0.946
NC_002951_7	7.3\|1182320\|37\|NC_002951\|CRT	1182320-1182356	37	NC_002951.2	1178352-1178388	2	0.946
NC_002951_9	9.1\|2008883\|33\|NC_002951\|CRISPRCasFinder	2008883-2008915	33	NC_002951.2	1479017-1479049	2	0.939
NC_002951_11	11.1\|2325079\|33\|NC_002951\|CRT	2325079-2325111	33	NC_002951.2	1390481-1390513	2	0.939
NC_002951_11	11.1\|2325079\|33\|NC_002951\|CRT	2325079-2325111	33	NC_002951.2	1479017-1479049	2	0.939
NC_002951_11	11.1\|2325079\|33\|NC_002951\|CRT	2325079-2325111	33	NC_002951.2	2601579-2601611	2	0.939
NC_002951_11	11.2\|2325135\|36\|NC_002951\|CRT	2325135-2325170	36	NC_002951.2	1671653-1671688	2	0.944
NC_002951_11	11.2\|2325135\|36\|NC_002951\|CRT	2325135-2325170	36	NC_002951.2	2019627-2019662	2	0.944
NC_002951_11	11.3\|2325194\|33\|NC_002951\|CRT	2325194-2325226	33	NC_002951.2	856083-856115	2	0.939
NC_002951_11	11.3\|2325194\|33\|NC_002951\|CRT	2325194-2325226	33	NC_002951.2	1390481-1390513	2	0.939
NC_002951_11	11.3\|2325194\|33\|NC_002951\|CRT	2325194-2325226	33	NC_002951.2	2601579-2601611	2	0.939

1. spacer 4.1|850701|29|NC_002951|CRISPRCasFinder matches to position: 2766975-2767003, mismatch: 0, identity: 1.0

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtttgtagaatttcttttcgaaa	Protospacer
*****************************

2. spacer 5.1|899257|34|NC_002951|CRISPRCasFinder matches to position: 1390526-1390559, mismatch: 0, identity: 1.0

attgggaatccaatttctctttgttggggcccat	CRISPR spacer
attgggaatccaatttctctttgttggggcccat	Protospacer
**********************************

3. spacer 5.1|899257|34|NC_002951|CRISPRCasFinder matches to position: 1478971-1479004, mismatch: 0, identity: 1.0

attgggaatccaatttctctttgttggggcccat	CRISPR spacer
attgggaatccaatttctctttgttggggcccat	Protospacer
**********************************

4. spacer 7.2|1182264|37|NC_002951|CRT matches to position: 418827-418863, mismatch: 0, identity: 1.0

agctgacgaaaagtcagcttacaataatgtgcaagtt	CRISPR spacer
agctgacgaaaagtcagcttacaataatgtgcaagtt	Protospacer
*************************************

5. spacer 7.2|1182264|37|NC_002951|CRT matches to position: 1081408-1081444, mismatch: 0, identity: 1.0

agctgacgaaaagtcagcttacaataatgtgcaagtt	CRISPR spacer
agctgacgaaaagtcagcttacaataatgtgcaagtt	Protospacer
*************************************

6. spacer 7.2|1182264|37|NC_002951|CRT matches to position: 1390485-1390521, mismatch: 0, identity: 1.0

agctgacgaaaagtcagcttacaataatgtgcaagtt	CRISPR spacer
agctgacgaaaagtcagcttacaataatgtgcaagtt	Protospacer
*************************************

7. spacer 7.3|1182320|37|NC_002951|CRT matches to position: 149328-149364, mismatch: 0, identity: 1.0

gaaattggattcccaatttctacagacaatgcaagtt	CRISPR spacer
gaaattggattcccaatttctacagacaatgcaagtt	Protospacer
*************************************

8. spacer 7.3|1182320|37|NC_002951|CRT matches to position: 692582-692618, mismatch: 0, identity: 1.0

gaaattggattcccaatttctacagacaatgcaagtt	CRISPR spacer
gaaattggattcccaatttctacagacaatgcaagtt	Protospacer
*************************************

9. spacer 7.3|1182320|37|NC_002951|CRT matches to position: 808641-808677, mismatch: 0, identity: 1.0

gaaattggattcccaatttctacagacaatgcaagtt	CRISPR spacer
gaaattggattcccaatttctacagacaatgcaagtt	Protospacer
*************************************

10. spacer 7.3|1182320|37|NC_002951|CRT matches to position: 809611-809647, mismatch: 0, identity: 1.0

gaaattggattcccaatttctacagacaatgcaagtt	CRISPR spacer
gaaattggattcccaatttctacagacaatgcaagtt	Protospacer
*************************************

11. spacer 7.3|1182320|37|NC_002951|CRT matches to position: 1390543-1390579, mismatch: 0, identity: 1.0

gaaattggattcccaatttctacagacaatgcaagtt	CRISPR spacer
gaaattggattcccaatttctacagacaatgcaagtt	Protospacer
*************************************

12. spacer 7.3|1182320|37|NC_002951|CRT matches to position: 1478951-1478987, mismatch: 0, identity: 1.0

gaaattggattcccaatttctacagacaatgcaagtt	CRISPR spacer
gaaattggattcccaatttctacagacaatgcaagtt	Protospacer
*************************************

13. spacer 7.3|1182320|37|NC_002951|CRT matches to position: 2010332-2010368, mismatch: 0, identity: 1.0

gaaattggattcccaatttctacagacaatgcaagtt	CRISPR spacer
gaaattggattcccaatttctacagacaatgcaagtt	Protospacer
*************************************

14. spacer 4.1|850701|29|NC_002951|CRISPRCasFinder matches to position: 418944-418972, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcttgtagaatttcttttcgaaa	Protospacer
*******.*********************

15. spacer 4.1|850701|29|NC_002951|CRISPRCasFinder matches to position: 418999-419027, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcttgtagaatttcttttcgaaa	Protospacer
*******.*********************

16. spacer 4.1|850701|29|NC_002951|CRISPRCasFinder matches to position: 1850370-1850398, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaa	Protospacer
********.********************

17. spacer 6.1|964053|26|NC_002951|CRT matches to position: 963997-964022, mismatch: 1, identity: 0.962

cggggccccaacacagaggctggcgg	CRISPR spacer
cggggccccaacacagaggctggtgg	Protospacer
***********************.**

18. spacer 7.1|1182208|37|NC_002951|CRT matches to position: 1850367-1850403, mismatch: 1, identity: 0.973

gaatttcaaaaagaaattctacagacaatgcaagttg	CRISPR spacer
gaatttcgaaaagaaattctacagacaatgcaagttg	Protospacer
*******.*****************************

19. spacer 7.2|1182264|37|NC_002951|CRT matches to position: 1479009-1479045, mismatch: 1, identity: 0.973

agctgacgaaaagtcagcttacaataatgtgcaagtt	CRISPR spacer
agatgacgaaaagtcagcttacaataatgtgcaagtt	Protospacer
** **********************************

20. spacer 7.2|1182264|37|NC_002951|CRT matches to position: 1671706-1671742, mismatch: 1, identity: 0.973

agctgacgaaaagtcagcttacaataatgtgcaagtt	CRISPR spacer
agctgacgaaaagtcagcttactataatgtgcaagtt	Protospacer
********************** **************

21. spacer 7.2|1182264|37|NC_002951|CRT matches to position: 2601571-2601607, mismatch: 1, identity: 0.973

agctgacgaaaagtcagcttacaataatgtgcaagtt	CRISPR spacer
agctgacgaaaagtcagcttacaataatgtgcgagtt	Protospacer
********************************.****

22. spacer 7.3|1182320|37|NC_002951|CRT matches to position: 1107668-1107704, mismatch: 1, identity: 0.973

gaaattggattcccaatttctacagacaatgcaagtt	CRISPR spacer
gaaattggattcccaatttctacagacaatgtaagtt	Protospacer
*******************************.*****

23. spacer 7.3|1182320|37|NC_002951|CRT matches to position: 2491618-2491654, mismatch: 1, identity: 0.973

gaaattggattcccaatttctacagacaatgcaagtt	CRISPR spacer
gaaattggattcccaatttctagagacaatgcaagtt	Protospacer
********************** **************

24. spacer 9.1|2008883|33|NC_002951|CRISPRCasFinder matches to position: 1390481-1390513, mismatch: 1, identity: 0.97

cattatcgtaagctgacttttcgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
******.**************************

25. spacer 9.1|2008883|33|NC_002951|CRISPRCasFinder matches to position: 1671714-1671746, mismatch: 1, identity: 0.97

cattatcgtaagctgacttttcgtcagcttctg	CRISPR spacer
cattatagtaagctgacttttcgtcagcttctg	Protospacer
****** **************************

26. spacer 9.1|2008883|33|NC_002951|CRISPRCasFinder matches to position: 2601579-2601611, mismatch: 1, identity: 0.97

cattatcgtaagctgacttttcgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
******.**************************

27. spacer 11.2|2325135|36|NC_002951|CRT matches to position: 1850363-1850398, mismatch: 1, identity: 0.972

tgcattgtctgtagaatttctttttgaaattctcta	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaattctcta	Protospacer
************************.***********

28. spacer 4.1|850701|29|NC_002951|CRISPRCasFinder matches to position: 899299-899327, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

29. spacer 4.1|850701|29|NC_002951|CRISPRCasFinder matches to position: 983692-983720, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

30. spacer 4.1|850701|29|NC_002951|CRISPRCasFinder matches to position: 1671653-1671681, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

31. spacer 4.1|850701|29|NC_002951|CRISPRCasFinder matches to position: 2019627-2019655, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcctttcgaaa	Protospacer
********.***********.********

32. spacer 4.1|850701|29|NC_002951|CRISPRCasFinder matches to position: 2516905-2516933, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

33. spacer 6.1|964053|26|NC_002951|CRT matches to position: 819095-819120, mismatch: 2, identity: 0.923

cggggccccaacacagaggctggcgg	CRISPR spacer
cggggccccaacacagaagcaggcgg	Protospacer
*****************.** *****

34. spacer 6.1|964053|26|NC_002951|CRT matches to position: 1182359-1182384, mismatch: 2, identity: 0.923

cggggccccaacacagaggctggcgg	CRISPR spacer
cggggccccaacatagaagctggcgg	Protospacer
*************.***.********

35. spacer 6.1|964053|26|NC_002951|CRT matches to position: 2766943-2766968, mismatch: 2, identity: 0.923

cggggccccaacacagaggctggcgg	CRISPR spacer
cggggccccaacatagaagctggcgg	Protospacer
*************.***.********

36. spacer 6.3|964167|26|NC_002951|CRT matches to position: 418810-418835, mismatch: 2, identity: 0.923

cggggccccaacacagaagctggcga	CRISPR spacer
cggggccccaacaaagaagctgacga	Protospacer
************* ********.***

37. spacer 7.1|1182208|37|NC_002951|CRT matches to position: 899294-899330, mismatch: 2, identity: 0.946

gaatttcaaaaagaaattctacagacaatgcaagttg	CRISPR spacer
gaatttcgaaaagaaattctacaggcaatgcaagttg	Protospacer
*******.****************.************

38. spacer 7.1|1182208|37|NC_002951|CRT matches to position: 1671648-1671684, mismatch: 2, identity: 0.946

gaatttcaaaaagaaattctacagacaatgcaagttg	CRISPR spacer
gaatttcgaaaagaaattctacaggcaatgcaagttg	Protospacer
*******.****************.************

39. spacer 7.1|1182208|37|NC_002951|CRT matches to position: 2019622-2019658, mismatch: 2, identity: 0.946

gaatttcaaaaagaaattctacagacaatgcaagttg	CRISPR spacer
gaatttcgaaaggaaattctacagacaatgcaagttg	Protospacer
*******.***.*************************

40. spacer 7.1|1182208|37|NC_002951|CRT matches to position: 2516902-2516938, mismatch: 2, identity: 0.946

gaatttcaaaaagaaattctacagacaatgcaagttg	CRISPR spacer
gaatttcgaaaagaaattctacaggcaatgcaagttg	Protospacer
*******.****************.************

41. spacer 7.1|1182208|37|NC_002951|CRT matches to position: 2766970-2767006, mismatch: 2, identity: 0.946

gaatttcaaaaagaaattctacagacaatgcaagttg	CRISPR spacer
gaatttcgaaaagaaattctacaaacaatgcaagttg	Protospacer
*******.***************.*************

42. spacer 7.2|1182264|37|NC_002951|CRT matches to position: 856075-856111, mismatch: 2, identity: 0.946

agctgacgaaaagtcagcttacaataatgtgcaagtt	CRISPR spacer
agctggcggaaagtcagcttacaataatgtgcaagtt	Protospacer
*****.**.****************************

43. spacer 7.2|1182264|37|NC_002951|CRT matches to position: 1178296-1178332, mismatch: 2, identity: 0.946

agctgacgaaaagtcagcttacaataatgtgcaagtt	CRISPR spacer
agctggcgaaaagtcagcttacaaaaatgtgcaagtt	Protospacer
*****.****************** ************

44. spacer 7.2|1182264|37|NC_002951|CRT matches to position: 1182376-1182412, mismatch: 2, identity: 0.946

agctgacgaaaagtcagcttacaataatgtgcaagtt	CRISPR spacer
agctggcggaaagtcagcttacaataatgtgcaagtt	Protospacer
*****.**.****************************

45. spacer 7.3|1182320|37|NC_002951|CRT matches to position: 1178352-1178388, mismatch: 2, identity: 0.946

gaaattggattcccaatttctacagacaatgcaagtt	CRISPR spacer
gaaattggaaccccaatttctacagacaatgcaagtt	Protospacer
********* .**************************

46. spacer 9.1|2008883|33|NC_002951|CRISPRCasFinder matches to position: 1479017-1479049, mismatch: 2, identity: 0.939

cattatcgtaagctgacttttcgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcatcttctg	Protospacer
******.******************* ******

47. spacer 11.1|2325079|33|NC_002951|CRT matches to position: 1390481-1390513, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********** *************** ******

48. spacer 11.1|2325079|33|NC_002951|CRT matches to position: 1479017-1479049, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcatcttctg	Protospacer
********** ***************.******

49. spacer 11.1|2325079|33|NC_002951|CRT matches to position: 2601579-2601611, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********** *************** ******

50. spacer 11.2|2325135|36|NC_002951|CRT matches to position: 1671653-1671688, mismatch: 2, identity: 0.944

tgcattgtctgtagaatttctttttgaaattctcta	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaattctcta	Protospacer
*******.****************.***********

51. spacer 11.2|2325135|36|NC_002951|CRT matches to position: 2019627-2019662, mismatch: 2, identity: 0.944

tgcattgtctgtagaatttctttttgaaattctcta	CRISPR spacer
tgcattgtctgtagaatttcctttcgaaattctcta	Protospacer
********************.***.***********

52. spacer 11.3|2325194|33|NC_002951|CRT matches to position: 856083-856115, mismatch: 2, identity: 0.939

cattattgtaagctgactttctgtcagcttctg	CRISPR spacer
cattattgtaagctgactttccgccagcttctg	Protospacer
*********************.*.*********

53. spacer 11.3|2325194|33|NC_002951|CRT matches to position: 1390481-1390513, mismatch: 2, identity: 0.939

cattattgtaagctgactttctgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********************..***********

54. spacer 11.3|2325194|33|NC_002951|CRT matches to position: 2601579-2601611, mismatch: 2, identity: 0.939

cattattgtaagctgactttctgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********************..***********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_002951_6	6.4\|964223\|53\|NC_002951\|CRT	964223-964275	53	MG543995	Staphylococcus phage UPMK_1, partial genome	76246-76298	4	0.925
NC_002951_6	6.3\|964167\|26\|NC_002951\|CRT	964167-964192	26	NZ_CP022541	Antarctobacter heliothermus strain SMS3 plasmid pSMS3-1, complete sequence	333735-333760	5	0.808
NC_002951_4	4.1\|850701\|29\|NC_002951\|CRISPRCasFinder	850701-850729	29	MN693281	Marine virus AFVG_25M371, complete genome	6448-6476	7	0.759
NC_002951_9	9.1\|2008883\|33\|NC_002951\|CRISPRCasFinder	2008883-2008915	33	NC_021536	Synechococcus phage S-IOM18 genomic sequence	159745-159777	10	0.697

1. spacer 6.4|964223|53|NC_002951|CRT matches to MG543995 (Staphylococcus phage UPMK_1, partial genome) position: , mismatch: 4, identity: 0.925

ggtgggacgacgaaataaattttgcgaaaatatcatttctgtcccactcccaa	CRISPR spacer
ggtgggacgacgaaataaattttgagaaactatcatttctgtcccactccctt	Protospacer
************************ **** *********************

2. spacer 6.3|964167|26|NC_002951|CRT matches to NZ_CP022541 (Antarctobacter heliothermus strain SMS3 plasmid pSMS3-1, complete sequence) position: , mismatch: 5, identity: 0.808

cggggccccaacacagaagctggcga	CRISPR spacer
taaggcctcaacacagaagctggcgt	Protospacer
...****.*****************

3. spacer 4.1|850701|29|NC_002951|CRISPRCasFinder matches to MN693281 (Marine virus AFVG_25M371, complete genome) position: , mismatch: 7, identity: 0.759

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtttgtaggatttcttctaagtg	Protospacer
**************.*******.* .. .

4. spacer 9.1|2008883|33|NC_002951|CRISPRCasFinder matches to NC_021536 (Synechococcus phage S-IOM18 genomic sequence) position: , mismatch: 10, identity: 0.697

cattatcgtaagctgacttttcgtcagcttctg	CRISPR spacer
ttttatcgtaaggtgagttttcgtcaagcacct	Protospacer
. ********** *** *********. . *.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

354784 : 397516

Staphylococcus_phage(87.14%)

terminase,plate,integrase,portal,protease,head,capsid,holin,tail

attL 354674:354691|attR 398250:398267

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
354674:354691	attL	NA	NA	NA	NA
WP_000264187.1\|354784_355990_-\|integrase	site-specific integrase	A0A1X9H094	Staphylococcus_phage	5.0e-222	100.0
WP_001582614.1\|356183_356897_-	type II toxin-antitoxin system PemK/MazF family toxin	A0A1X9H026	Staphylococcus_phage	2.5e-128	99.6
WP_000705240.1\|356974_357157_-	hypothetical protein	A0A2I6PDR4	Staphylococcus_phage	5.3e-27	100.0
WP_000358220.1\|357356_358076_-	helix-turn-helix transcriptional regulator	Q8SDX2	Staphylococcus_phage	9.8e-133	100.0
WP_001198674.1\|358217_358436_+	helix-turn-helix transcriptional regulator	Q8SDX1	Staphylococcus_phage	8.3e-35	98.6
WP_001153965.1\|358450_358759_+	hypothetical protein	S4V9P0	Staphylococcus_phage	1.3e-49	100.0
WP_001148570.1\|358915_359707_+	phage antirepressor KilAC domain-containing protein	A0A0E3T9K2	Staphylococcus_phage	4.2e-145	99.6
WP_000187184.1\|359707_359932_+	hypothetical protein	A0A0F6N4M2	Staphylococcus_phage	3.2e-34	100.0
WP_001025401.1\|359971_360217_+	DUF2829 domain-containing protein	A0A2I6PF15	Staphylococcus_phage	5.1e-41	100.0
WP_001128433.1\|360185_360551_-	hypothetical protein	A0A2I6PF07	Staphylococcus_phage	2.4e-63	100.0
WP_031903992.1\|360607_360805_+	hypothetical protein	A7TWF5	Staphylococcus_phage	8.6e-23	95.4
WP_000773060.1\|360791_361172_-	DUF2513 domain-containing protein	Q4ZCQ5	Staphylococcus_virus	3.8e-67	99.2
WP_000389907.1\|361219_361411_+	hypothetical protein	A7TWL8	Staphylococcus_phage	1.1e-25	98.4
WP_000801109.1\|361388_361640_-	hypothetical protein	A7TWL9	Staphylococcus_phage	1.9e-38	100.0
WP_001124196.1\|361694_361958_+	helix-turn-helix domain-containing protein	A0A2I6PEL8	Staphylococcus_phage	7.4e-46	98.9
WP_001285962.1\|361970_362132_+	DUF1270 domain-containing protein	A9CR58	Staphylococcus_phage	8.6e-21	100.0
WP_001097093.1\|362221_362539_+	hypothetical protein	A0A2I6PEL3	Staphylococcus_phage	3.6e-31	95.8
WP_001556704.1\|362543_362804_+	DUF1108 family protein	G4KNN5	Staphylococcus_phage	2.0e-43	100.0
WP_000815401.1\|362813_363035_+	DUF2483 family protein	A7TWM6	Staphylococcus_phage	3.2e-34	100.0
WP_000139722.1\|363027_363651_+	DUF1071 domain-containing protein	A0A2H4PQQ6	Staphylococcus_phage	5.7e-113	99.0
WP_000934777.1\|363650_364070_+	single-stranded DNA-binding protein	Q4ZA54	Staphylococcus_virus	5.3e-62	99.3
WP_001124444.1\|364083_364779_+	hypothetical protein	A0A0E3XBQ6	Staphylococcus_phage	9.5e-133	98.7
WP_000504976.1\|364750_365551_+	phage replisome organizer N-terminal domain-containing protein	Q8SDW2	Staphylococcus_phage	8.7e-106	98.5
WP_001132238.1\|365550_365907_+	hypothetical protein	M9NS37	Staphylococcus_phage	6.9e-63	98.3
WP_001106168.1\|365903_367145_+	AAA family ATPase	C8CGZ3	Staphylococcus_phage	2.6e-229	100.0
WP_001095146.1\|367141_367357_+	hypothetical protein	B7T0B0	Staphylococcus_virus	1.2e-33	95.8
WP_001123688.1\|367359_367581_+	DUF3269 family protein	Q9G021	Staphylococcus_phage	1.3e-35	100.0
WP_000451862.1\|367590_368016_+	DNA N-6-adenine-methyltransferase	Q4ZAC6	Staphylococcus_virus	8.0e-82	100.0
WP_000049810.1\|368012_368417_+	DUF1064 domain-containing protein	A0A0H4ISQ5	Staphylococcus_phage	9.0e-67	100.0
WP_001187232.1\|368421_368607_+	DUF3113 family protein	A0A0H4IPE3	Staphylococcus_phage	1.2e-26	96.7
WP_000772916.1\|368607_368865_+	helix-turn-helix transcriptional regulator	Q4ZBU1	Staphylococcus_virus	4.1e-41	100.0
WP_000029384.1\|368876_369233_+	hypothetical protein	A0A0F6N3E3	Staphylococcus_phage	2.1e-59	97.5
WP_000132205.1\|369236_369479_+	hypothetical protein	A0A0N7E0T2	Staphylococcus_phage	2.5e-40	100.0
WP_000693987.1\|369492_369699_+	hypothetical protein	A0A0N9BAW9	Staphylococcus_phage	3.0e-34	100.0
WP_000695759.1\|369701_370103_+	hypothetical protein	A0A0N7E0T5	Staphylococcus_phage	7.0e-72	100.0
WP_000979209.1\|370099_370447_+	hypothetical protein	D2JGL4	Staphylococcus_phage	5.9e-59	100.0
WP_000144708.1\|370443_370752_+	hypothetical protein	Q4ZBK6	Staphylococcus_phage	8.1e-52	100.0
WP_001065023.1\|370744_370981_+	DUF1024 family protein	C8CH04	Staphylococcus_phage	1.1e-35	100.0
WP_000185654.1\|370985_371528_+	dUTP pyrophosphatase	Q4ZD81	Staphylococcus_virus	1.5e-96	100.0
WP_000195770.1\|371564_371771_+	DUF1381 domain-containing protein	B7T0C2	Staphylococcus_virus	6.0e-19	95.6
WP_000141183.1\|371767_371962_+	hypothetical protein	A0A0N7E0T8	Staphylococcus_phage	1.0e-28	98.4
WP_001072795.1\|371958_372162_+	hypothetical protein	A0A0N9BAX5	Staphylococcus_phage	5.2e-31	100.0
WP_000166078.1\|372154_372307_+	transcriptional activator RinB	A0A2I6PEM5	Staphylococcus_phage	4.4e-19	98.0
WP_000265258.1\|372374_372575_+	DUF1514 family protein	A0A2I6PF41	Staphylococcus_phage	2.9e-26	100.0
WP_000513702.1\|372894_373332_+	transcriptional regulator	B7T0I6	Staphylococcus_virus	6.1e-77	100.0
WP_000160689.1\|373488_373803_+	HNH endonuclease	A0A2I6PDC4	Staphylococcus_phage	2.5e-56	100.0
WP_000778932.1\|373931_374237_+\|terminase	P27 family phage terminase small subunit	A0A2I6PE27	Staphylococcus_phage	2.9e-49	100.0
WP_000153555.1\|374226_375918_+\|terminase	terminase large subunit	A0A2I6PE44	Staphylococcus_phage	0.0e+00	100.0
WP_001100669.1\|375922_377161_+\|portal	phage portal protein	A0A2K9VBP0	Staphylococcus_phage	6.9e-235	100.0
WP_000061866.1\|377144_377918_+\|protease	Clp protease ClpP	A0A2I6PEQ7	Staphylococcus_phage	2.4e-137	100.0
WP_001142734.1\|377929_379093_+\|capsid	phage major capsid protein	A0A2I6PEQ3	Staphylococcus_phage	1.2e-217	100.0
WP_000050973.1\|379161_379440_+\|head,tail	phage gp6-like head-tail connector protein	A0A2I6PEQ1	Staphylococcus_phage	2.1e-46	100.0
WP_000395498.1\|379451_379784_+	hypothetical protein	A0A2I6PES3	Staphylococcus_phage	4.1e-57	100.0
WP_000110023.1\|379780_380182_+	hypothetical protein	A0A2I6PF54	Staphylococcus_phage	8.1e-68	100.0
WP_001023806.1\|380182_380578_+	DUF3168 domain-containing protein	A0A2I6PEQ4	Staphylococcus_phage	8.8e-67	100.0
WP_000807536.1\|380612_381254_+\|tail	tail protein	A0A2I6PEP6	Staphylococcus_phage	5.9e-121	100.0
WP_000169127.1\|381345_381801_+	Ig domain-containing protein	A0A2I6PER6	Staphylococcus_phage	5.7e-78	100.0
WP_000589167.1\|381858_382209_+	hypothetical protein	A0A2I6PEQ2	Staphylococcus_phage	1.1e-55	100.0
WP_000438833.1\|382250_382409_+	hypothetical protein	A0A2I6PES8	Staphylococcus_phage	1.2e-19	100.0
WP_001003428.1\|382422_388623_+\|tail	phage tail tape measure protein	Q4ZCL0	Staphylococcus_virus	0.0e+00	99.6
WP_001190533.1\|388622_389447_+\|tail	phage tail family protein	A0A2I6PER3	Staphylococcus_phage	4.1e-159	100.0
WP_000384474.1\|389455_391039_+\|tail	phage tail protein	A0A2I6PEQ5	Staphylococcus_phage	9.3e-309	100.0
WP_000179858.1\|391038_391329_+	hypothetical protein	U5U457	Staphylococcus_phage	2.1e-49	100.0
WP_000429557.1\|391344_393255_+	hypothetical protein	A0A2I6PEQ9	Staphylococcus_phage	0.0e+00	99.8
WP_000067122.1\|393254_394721_+\|plate	phage baseplate upper protein	A0A2I6PES7	Staphylococcus_phage	2.9e-272	99.4
WP_001166599.1\|394720_395110_+	DUF2977 domain-containing protein	A0A2I6PER1	Staphylococcus_phage	2.2e-62	100.0
WP_001125229.1\|395102_395267_+	XkdX family protein	A0A2I6PES4	Staphylococcus_phage	2.5e-23	98.1
WP_000466784.1\|395312_395612_+	DUF2951 domain-containing protein	A0A2I6PER2	Staphylococcus_phage	2.0e-31	100.0
WP_000339146.1\|395747_396050_+\|holin	phage holin	A0A2I6PET6	Staphylococcus_phage	7.0e-48	100.0
WP_000930258.1\|396061_397516_+	N-acetylmuramoyl-L-alanine amidase	A0A0N6WMR3	Staphylococcus_phage	3.0e-290	100.0
398250:398267	attR	NA	NA	NA	NA

DBSCAN-SWA_2

787730 : 795550

Hokovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244412.1\|787730_788786_-	two-component system sensor histidine kinase SaeS	A0A1V0SGX0	Hokovirus	2.1e-14	30.0
WP_000149344.1\|788785_789472_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037807.1\|789446_789920_-	DoxX family protein	NA	NA	NA	NA
WP_001093553.1\|790261_790702_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637687.1\|790981_791566_-	hypothetical protein	NA	NA	NA	NA
WP_001062972.1\|791664_792378_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941336.1\|792381_792801_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446724.1\|792802_793471_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000604514.1\|793821_794415_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	4.4e-38	42.9
WP_001217785.1\|794398_795550_+	anthranilate synthase component I family protein	A0A0B5J984	Pandoravirus	1.6e-23	35.7

DBSCAN-SWA_3

807522 : 822309

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663030.1\|807522_808581_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	7.9e-22	26.7
WP_000197271.1\|808931_809474_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429014.1\|810153_811071_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	3.7e-07	22.0
WP_001790641.1\|811161_811263_+	hypothetical protein	NA	NA	NA	NA
WP_000193751.1\|811340_812846_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930014.1\|813186_813687_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	5.9e-52	71.5
WP_001068497.1\|813706_814573_-	DMT family transporter	NA	NA	NA	NA
WP_000692521.1\|815373_815772_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_000855505.1\|815734_817840_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|817957_818929_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000499195.1\|819442_819598_+	hypothetical protein	NA	NA	NA	NA
WP_000876318.1\|819636_820608_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.3e-139	78.9
WP_001245577.1\|820594_821551_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
WP_000616842.1\|821547_822309_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	8.5e-18	31.6

DBSCAN-SWA_4

900795 : 922004

Staphylococcus_phage(77.78%)

coat,terminase,integrase

attL 903332:903348|attR 919267:919283

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000571218.1\|900795_901821_+	methionine ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.2e-27	36.8
WP_000520233.1\|901813_902509_+	ABC transporter permease	NA	NA	NA	NA
WP_000732326.1\|902526_903348_+	MetQ/NlpA family ABC transporter substrate-binding protein	NA	NA	NA	NA
903332:903348	attL	NA	NA	NA	NA
WP_000266157.1\|903490_904711_-\|integrase	site-specific integrase	Q4ZE80	Staphylococcus_phage	6.4e-100	47.5
WP_000733775.1\|904799_905528_-	staphylococcal enterotoxin type K	A0EX09	Staphylococcus_phage	1.9e-22	32.3
WP_001033316.1\|905551_906280_-	staphylococcal enterotoxin type Q	A0EX09	Staphylococcus_phage	2.3e-28	35.4
WP_001228759.1\|906349_906781_-	hypothetical protein	Q4ZCB6	Staphylococcus_virus	5.1e-36	56.0
WP_000281657.1\|906797_907256_-	ImmA/IrrE family metallo-endopeptidase	A0A0H4J322	Staphylococcus_phage	5.1e-66	83.0
WP_001260004.1\|907267_907600_-	helix-turn-helix transcriptional regulator	A0A1J0MFC1	Staphylococcus_phage	1.6e-37	74.5
WP_000243851.1\|907792_908056_+	helix-turn-helix transcriptional regulator	A0A2H4J9X2	uncultured_Caudovirales_phage	3.1e-36	94.8
WP_000091731.1\|908048_908321_+	winged helix-turn-helix domain-containing protein	Q4ZE77	Staphylococcus_phage	9.7e-41	90.0
WP_000784875.1\|908332_908479_+	hypothetical protein	NA	NA	NA	NA
WP_001058486.1\|908471_908681_+	hypothetical protein	Q4ZE76	Staphylococcus_phage	1.7e-29	94.2
WP_001103942.1\|908683_909004_+	DUF1474 family protein	Q4ZE75	Staphylococcus_phage	1.3e-20	51.9
WP_001002732.1\|909067_909937_+	primase alpha helix C-terminal domain-containing protein	A0A1W6JQL5	Staphylococcus_phage	3.4e-156	92.7
WP_000390455.1\|909953_911411_+	hypothetical protein	A0A1W6JQD6	Staphylococcus_phage	1.0e-277	96.1
WP_001039168.1\|911711_912074_+	hypothetical protein	A0A1W6JQD5	Staphylococcus_phage	8.9e-66	99.2
WP_000998181.1\|912075_912360_+	hypothetical protein	A0A1W6JQE4	Staphylococcus_phage	1.9e-47	95.7
WP_001019764.1\|912356_912998_+	hypothetical protein	Q4ZE67	Staphylococcus_phage	1.5e-108	91.5
WP_001190615.1\|913514_913856_+	hypothetical protein	Q4ZE66	Staphylococcus_phage	1.4e-57	99.1
WP_000846285.1\|913867_914446_+	hypothetical protein	A0A2H4JBG0	uncultured_Caudovirales_phage	1.4e-28	38.4
WP_000448101.1\|914463_914682_+	hypothetical protein	NA	NA	NA	NA
WP_000771368.1\|914732_915260_+\|coat	spore coat protein	A0A1W6JQH7	Staphylococcus_phage	3.5e-87	97.1
WP_000358777.1\|915262_915604_+	hypothetical protein	A0A1W6JQM3	Staphylococcus_phage	1.4e-57	98.2
WP_001293067.1\|915600_916170_+\|terminase	terminase small subunit	Q4ZE85	Staphylococcus_phage	1.0e-100	97.9
WP_000278085.1\|916477_917278_+	staphylococcal enterotoxin type B	A0A097PAT7	Streptococcus_pyogenes_phage	1.0e-53	49.4
WP_001035631.1\|917355_917913_-	DUF4888 domain-containing protein	A0A1W6JQE5	Staphylococcus_phage	1.4e-70	73.8
WP_001795626.1\|918285_918438_+	hypothetical protein	A0A0F6N3H2	Staphylococcus_phage	7.6e-19	98.0
WP_000139424.1\|918508_918619_+	hypothetical protein	W5R8J7	Staphylococcus_phage	2.4e-11	94.4
WP_001286805.1\|918620_918806_+	hypothetical protein	A0A0F6N3H3	Staphylococcus_phage	2.7e-26	100.0
WP_000752917.1\|919636_919831_+	CsbD family protein	NA	NA	NA	NA
919267:919283	attR	NA	NA	NA	NA
WP_001183858.1\|920063_920915_-	DUF368 domain-containing protein	NA	NA	NA	NA
WP_000168845.1\|921242_922004_+	Fe-S cluster assembly ATPase SufC	A0A1V0SE00	Indivirus	4.4e-06	23.3

DBSCAN-SWA_5

1009157 : 1062934

Streptococcus_phage(33.33%)

bacteriocin,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000448934.1\|1009157_1010147_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_000258003.1\|1010441_1010837_+	transcriptional regulator Spx	NA	NA	NA	NA
WP_001217722.1\|1011207_1011927_+	adaptor protein MecA	NA	NA	NA	NA
WP_000959287.1\|1012047_1013034_+	competence protein CoiA	NA	NA	NA	NA
WP_000082731.1\|1013081_1014890_+	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	9.3e-47	24.4
WP_000896699.1\|1015349_1016156_-\|protease	protease adaptor protein YjbH	NA	NA	NA	NA
WP_000214065.1\|1016178_1016544_-	truncated hemoglobin	NA	NA	NA	NA
WP_000224622.1\|1016647_1017241_-	CYTH domain-containing protein	NA	NA	NA	NA
WP_001242102.1\|1017426_1017774_+	hypothetical protein	NA	NA	NA	NA
WP_001077683.1\|1017790_1018426_+	GTP pyrophosphokinase family protein	NA	NA	NA	NA
WP_001270834.1\|1018442_1019252_+	NAD kinase	NA	NA	NA	NA
WP_000669939.1\|1019248_1020103_+	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_000062417.1\|1020123_1021509_+	magnesium transporter	NA	NA	NA	NA
WP_000933195.1\|1023640_1024411_+	enoyl-ACP reductase FabI	NA	NA	NA	NA
WP_000933105.1\|1024605_1025691_-	AI-2E family transporter	NA	NA	NA	NA
WP_000570699.1\|1026032_1027601_+	alanine:cation symporter family protein	NA	NA	NA	NA
WP_001288681.1\|1027742_1028501_+	esterase family protein	NA	NA	NA	NA
WP_000600392.1\|1028694_1029204_+	2'-5' RNA ligase family protein	NA	NA	NA	NA
WP_001154222.1\|1029316_1030507_-	MFS transporter	NA	NA	NA	NA
WP_000258650.1\|1030484_1031660_-	diglucosyl diacylglycerol synthase	NA	NA	NA	NA
WP_000340118.1\|1032092_1033574_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
WP_001795833.1\|1033557_1033818_+	YueH family protein	NA	NA	NA	NA
WP_001049959.1\|1033817_1035380_+	peptide chain release factor 3	A0A1S5SF82	Streptococcus_phage	4.9e-36	28.2
WP_000928413.1\|1035681_1036485_+	TerC family protein	S5MAL1	Bacillus_phage	1.6e-30	40.5
WP_000455278.1\|1036703_1039028_+\|protease	serine protease	W5SAB9	Pithovirus	2.8e-11	27.4
WP_000021864.1\|1039044_1040403_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000414177.1\|1040541_1042053_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_000287265.1\|1042539_1043109_-	competence protein ComK	NA	NA	NA	NA
WP_000876826.1\|1043318_1043537_+	IDEAL domain-containing protein	NA	NA	NA	NA
WP_000668820.1\|1043617_1044604_-	lipoate--protein ligase	NA	NA	NA	NA
WP_000214898.1\|1044802_1044979_+	YkvS family protein	NA	NA	NA	NA
WP_001033871.1\|1044993_1045596_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001790623.1\|1046513_1046615_+	hypothetical protein	NA	NA	NA	NA
WP_078061421.1\|1046624_1046897_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000870806.1\|1046940_1048905_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000668623.1\|1048907_1049228_+	YxeA family protein	NA	NA	NA	NA
WP_000571178.1\|1049224_1049866_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.2e-19	33.7
WP_001795544.1\|1049953_1050244_-	hypothetical protein	NA	NA	NA	NA
WP_000410720.1\|1050522_1050810_+	hypothetical protein	NA	NA	NA	NA
WP_000719184.1\|1050815_1052297_+	glycosyltransferase	NA	NA	NA	NA
WP_000766009.1\|1052385_1052742_-	DoxX family protein	NA	NA	NA	NA
WP_001081351.1\|1053218_1054178_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001790177.1\|1054223_1054355_-	hypothetical protein	NA	NA	NA	NA
WP_000867357.1\|1054418_1054634_-	TM2 domain-containing protein	A0A060AN66	Enterococcus_phage	1.5e-07	49.1
WP_000620953.1\|1054798_1055350_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000070966.1\|1055401_1056340_-	1,4-dihydroxy-2-naphthoate polyprenyltransferase	NA	NA	NA	NA
WP_000190623.1\|1056521_1057883_+	isochorismate synthase MenF	NA	NA	NA	NA
WP_000526687.1\|1057869_1059543_+	2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase	NA	NA	NA	NA
WP_000150195.1\|1059529_1060333_+	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase	NA	NA	NA	NA
WP_000184947.1\|1060325_1061147_+	1,4-dihydroxy-2-naphthoyl-CoA synthase	NA	NA	NA	NA
WP_000284457.1\|1061385_1061715_-	staphostatin B	NA	NA	NA	NA
WP_001088780.1\|1061752_1062934_-\|protease	cysteine protease staphopain B	NA	NA	NA	NA

DBSCAN-SWA_6

1082921 : 1091394

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000861572.1\|1082921_1083404_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.2e-22	44.7
WP_001010412.1\|1083390_1084515_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174053.1\|1084518_1085223_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.3e-48	42.1
WP_000848350.1\|1085222_1085486_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666799.1\|1085487_1086159_+	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000032727.1\|1086151_1088341_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.0e-140	39.7
WP_000483713.1\|1088319_1089804_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.2e-45	31.7
WP_000030812.1\|1089796_1090825_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.3e-61	41.4
WP_000238664.1\|1090827_1091394_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.1e-29	40.1

DBSCAN-SWA_7

1643276 : 1651588

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001213908.1\|1643276_1644062_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
WP_000924214.1\|1644187_1645078_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
WP_001062180.1\|1645087_1646434_-	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	5.3e-55	33.7
WP_000683931.1\|1646547_1647648_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	5.2e-08	29.6
WP_000624561.1\|1647650_1648328_-\|tRNA	tRNA (adenine(22)-N(1))-methyltransferase TrmK	NA	NA	NA	NA
WP_001283055.1\|1648458_1649565_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_001217261.1\|1649788_1651588_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	4.6e-54	36.0

DBSCAN-SWA_8

1720725 : 1729768

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1720725_1721244_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_000594993.1\|1721265_1723539_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	1.2e-62	28.8
WP_000749795.1\|1723741_1726021_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1726295_1726556_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1726574_1727714_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001019172.1\|1727736_1728762_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005767.1\|1728763_1729768_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_9

1855596 : 1938731

Staphylococcus_phage(93.33%)

transposase,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001050554.1\|1855596_1862157_-	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	2.0e-304	98.1
WP_000836465.1\|1862482_1862794_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	1.6e-52	100.0
WP_001549041.1\|1862815_1865233_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.2
WP_001025061.1\|1865520_1866702_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	5.6e-218	100.0
WP_000526539.1\|1866811_1867765_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
WP_000764419.1\|1867761_1868325_+	class I SAM-dependent methyltransferase	A0A2H4PQV0	Staphylococcus_phage	8.3e-103	99.5
WP_000757541.1\|1868444_1868846_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266096.1\|1870424_1871252_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_001790712.1\|1871254_1871374_-	hypothetical protein	NA	NA	NA	NA
WP_001196354.1\|1871485_1872487_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7
WP_001008551.1\|1872608_1873073_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
WP_001159022.1\|1873085_1874267_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	6.6e-227	99.7
WP_000493892.1\|1874277_1874910_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.7e-112	99.5
WP_000077344.1\|1874916_1875960_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	6.3e-197	99.4
WP_001261677.1\|1876440_1877943_-	FAD/NAD(P)-binding protein	A0A2H4PQX2	Staphylococcus_phage	2.3e-30	100.0
WP_000221179.1\|1878465_1878780_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	2.0e-53	100.0
WP_000989121.1\|1878779_1880072_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	5.0e-228	99.5
WP_000163235.1\|1880089_1880485_+	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	6.3e-73	100.0
WP_001032833.1\|1880779_1881634_-	N-acetylglucosaminidase	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1881909_1882134_-	hypothetical protein	NA	NA	NA	NA
WP_000671052.1\|1882332_1882803_+	RNA polymerase sigma factor SigS	A0A2H4PQT5	Staphylococcus_phage	1.0e-82	99.4
WP_001153742.1\|1882915_1883359_+	competence protein ComK	NA	NA	NA	NA
WP_001030465.1\|1883345_1883789_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	3.0e-55	85.0
WP_001168904.1\|1884084_1884720_+\|protease	CPBP family intramembrane metalloprotease SdpA	NA	NA	NA	NA
WP_001096494.1\|1885159_1885873_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091445.1\|1886132_1886435_+	hypothetical protein	NA	NA	NA	NA
WP_001200542.1\|1886690_1887056_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-59	100.0
WP_000623474.1\|1887052_1887406_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	1.0e-21	99.1
WP_000453320.1\|1889488_1890322_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	9.6e-156	98.6
WP_000366154.1\|1890533_1891442_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	3.2e-136	98.7
WP_000933822.1\|1891566_1892760_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
WP_000109906.1\|1893130_1894723_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	100.0
WP_000093392.1\|1894858_1895344_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	4.9e-19	35.4
WP_002868962.1\|1895718_1896465_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	7.1e-142	98.4
WP_000672014.1\|1896469_1896943_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	4.7e-83	98.1
WP_000718107.1\|1897008_1897266_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778523.1\|1897262_1898264_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	4.8e-186	97.6
WP_000348360.1\|1898268_1899747_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.0e-281	97.0
WP_011443643.1\|1899905_1900361_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	3.0e-79	98.6
WP_001795535.1\|1900663_1901314_+	excalibur calcium-binding domain-containing protein	A0A2H4PQM8	Staphylococcus_phage	2.7e-44	88.4
WP_000070653.1\|1901394_1902390_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	7.1e-73	96.4
WP_000669046.1\|1902465_1903092_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	7.1e-79	82.7
WP_000627551.1\|1903132_1903477_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	6.3e-53	92.0
WP_000414205.1\|1903574_1904126_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	1.0e-20	94.1
WP_000494956.1\|1904343_1904985_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	2.6e-76	93.2
WP_000809857.1\|1905098_1905284_-	hypothetical protein	NA	NA	NA	NA
WP_000375476.1\|1905285_1905462_-	hypothetical protein	NA	NA	NA	NA
WP_000070811.1\|1905472_1905856_-	hypothetical protein	NA	NA	NA	NA
WP_001549059.1\|1906591_1906735_-\|transposase	transposase	A0A2H4PQU1	Staphylococcus_phage	6.4e-20	100.0
WP_001791893.1\|1907156_1907258_+	hypothetical protein	NA	NA	NA	NA
WP_001037045.1\|1907605_1907983_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000072576.1\|1913465_1914665_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	5.5e-229	99.7
WP_000028659.1\|1914657_1916214_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	2.3e-288	99.4
WP_001791797.1\|1916377_1916512_-	hypothetical protein	NA	NA	NA	NA
WP_001038688.1\|1916576_1917296_-\|protease	serine protease SplF	A0A2H4PQP1	Staphylococcus_phage	1.1e-131	100.0
WP_001038759.1\|1917446_1918163_-\|protease	serine protease SplE	A0A2H4PQN5	Staphylococcus_phage	1.1e-131	100.0
WP_011447030.1\|1918264_1918372_+	hypothetical protein	NA	NA	NA	NA
WP_001038708.1\|1918320_1919040_-\|protease	serine protease SplD	A0A2H4PQP9	Staphylococcus_phage	3.0e-129	99.2
WP_001038867.1\|1919160_1919880_-\|protease	serine protease SplC	A0A2H4PQP7	Staphylococcus_phage	1.2e-130	99.2
WP_001039447.1\|1919937_1920660_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	2.4e-131	99.6
WP_001039423.1\|1920784_1921501_-\|protease	serine protease SplA	A0A2H4PQN3	Staphylococcus_phage	2.0e-125	96.2
WP_001092763.1\|1922464_1923031_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	3.3e-99	100.0
WP_000586140.1\|1923504_1924203_-	hypothetical protein	A0A2H4PQH0	Staphylococcus_phage	3.8e-113	94.4
WP_000581552.1\|1924199_1924961_-	lantibiotic immunity ABC transporter MutE/EpiE family permease subunit	A0A2H4PQH2	Staphylococcus_phage	4.4e-131	100.0
WP_001096791.1\|1924957_1925650_-	lantibiotic protection ABC transporter ATP-binding subunit	A0A2H4PQG7	Staphylococcus_phage	6.2e-124	100.0
WP_000691541.1\|1925672_1927046_-	S8 family serine peptidase	A0A2H4PQH1	Staphylococcus_phage	2.9e-258	100.0
WP_000504439.1\|1927055_1927574_-	flavoprotein	A0A2H4PQG9	Staphylococcus_phage	2.0e-95	100.0
WP_000566316.1\|1927589_1928834_-	lanthionine synthetase C family protein	A0A2H4PQH9	Staphylococcus_phage	1.1e-237	99.8
WP_001092604.1\|1928826_1931820_-	lantibiotic dehydratase	A0A2H4PQG8	Staphylococcus_phage	0.0e+00	97.2
WP_000416756.1\|1931884_1932028_-	gallidermin/nisin family lantibiotic	A0A2H4PQH4	Staphylococcus_phage	5.3e-14	80.9
WP_001808146.1\|1932919_1934239_+\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA
WP_047212565.1\|1934264_1934429_-	gallidermin/nisin family lantibiotic	NA	NA	NA	NA
WP_000782464.1\|1934670_1935654_-	bi-component leukocidin LukED subunit D	A0A2H4PQH7	Staphylococcus_phage	2.3e-185	99.1
WP_000473596.1\|1935655_1936591_-	beta-channel forming cytolysin	A0A2H4PQI5	Staphylococcus_phage	1.4e-174	100.0
WP_001790220.1\|1937390_1937930_+	hypothetical protein	Q4ZCB9	Staphylococcus_virus	2.0e-61	76.8
WP_000206350.1\|1937942_1938731_+	DUF1828 domain-containing protein	A0A2H4PQI0	Staphylococcus_phage	5.3e-140	95.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_002951

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection