CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_008509	Leptospira borgpetersenii serovar Hardjo-bovis str. L550 chromosome 2, complete sequence	0 crisprs	csa3	0	0	1	0
NC_008508	Leptospira borgpetersenii serovar Hardjo-bovis str. L550 chromosome 1, complete sequence	2 crisprs	WYL,cas3,cas2,cas1,cas6e,cas5,cas7,cse2gr11,cas8e,RT,csa3,DinG,Cas9_archaeal	0	1	5	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

79120 : 139539

Leptospira_phage(28.57%)

transposase,integrase

attL 106216:106231|attR 139880:139895

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011669147.1\|79120_80215_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_017859247.1\|81213_81936_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_020780741.1\|81957_83127_-	helix-turn-helix domain-containing protein	S5WIW9	Leptospira_phage	5.9e-18	29.0
WP_011671296.1\|85507_86647_-	AraC family transcriptional regulator	S5WIW9	Leptospira_phage	2.9e-78	41.3
WP_011671297.1\|92524_93529_-	hypothetical protein	NA	NA	NA	NA
WP_011671298.1\|93525_94980_-	hypothetical protein	NA	NA	NA	NA
WP_011671299.1\|94981_96466_-	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_017859763.1\|97684_97960_+\|transposase	transposase	NA	NA	NA	NA
WP_157862197.1\|98007_98292_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_017859759.1\|99700_100258_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	1.3e-34	41.1
WP_011671300.1\|102193_103198_+	patatin-like phospholipase family protein	NA	NA	NA	NA
WP_011671301.1\|103604_105161_+	FAD-dependent dehydrogenase	NA	NA	NA	NA
WP_002729387.1\|105304_105544_-	hypothetical protein	NA	NA	NA	NA
106216:106231	attL	NA	NA	NA	NA
WP_011671302.1\|110654_111401_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_011671303.1\|111445_112930_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_011671304.1\|113003_113567_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_002729400.1\|113589_114105_-	hypothetical protein	NA	NA	NA	NA
WP_011671306.1\|116301_116745_+	DUF1564 family protein	NA	NA	NA	NA
WP_002756542.1\|116806_117784_+	ArsR family transcriptional regulator	A0A2H4J145	uncultured_Caudovirales_phage	6.7e-07	46.0
WP_002756526.1\|117786_119097_+	adenosylhomocysteinase	S4W1G4	Pandoravirus	4.1e-52	32.1
WP_011671307.1\|119172_119472_+	4Fe-4S binding protein	NA	NA	NA	NA
WP_011671308.1\|119518_123262_+	methionine synthase	A0A140XBC7	Dickeya_phage	2.7e-16	65.6
WP_002756533.1\|123311_123641_+	hypothetical protein	NA	NA	NA	NA
WP_011671309.1\|123970_124891_-	hypothetical protein	NA	NA	NA	NA
WP_011671310.1\|125003_126338_+	ATP-dependent 6-phosphofructokinase	NA	NA	NA	NA
WP_011671311.1\|126452_128201_-	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_011671312.1\|128364_129240_-	acetylglutamate kinase	NA	NA	NA	NA
WP_002722237.1\|129319_130075_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_011671313.1\|130204_131926_-	M61 family metallopeptidase	NA	NA	NA	NA
WP_011671314.1\|131926_132406_-	peroxiredoxin	NA	NA	NA	NA
WP_017859779.1\|133329_133698_+	hypothetical protein	NA	NA	NA	NA
WP_011671316.1\|133764_134865_+	hypothetical protein	NA	NA	NA	NA
WP_011669461.1\|136411_137506_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_002722257.1\|138642_139539_-\|integrase	tyrosine-type recombinase/integrase	A0A1C8E994	Bacillus_phage	6.7e-06	26.6
139880:139895	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_008508

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CRISPR-Cas detection and classification

Crispr_ID: NC_008508_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008508_1

2060785-2060859

Orphan

Consensus_repeat	Method
GCGGAGCGTTTAAAATTTGTCTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008508_1

>merge|NC_008508|1|2060785-2060859|CRISPRCasFinder
GCGGAGCGTTTAAAATTTGTCTTTCAACACGTTAGTTGAAAAATAGAGCGAAGCGGAGCGTTTAAAATTTGATCT

>NC_008508|1|1|2060785-2060859|CRISPRCasFinder
GCGGAGCGTTTAAAATTTGTCTT	TCAACACGTTAGTTGAAAAATAGAGCGAA
GCGGAGCGTTTAAAATTTGATCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008508.1\|WP_020780757.1\|2069866_2072575_-\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NC_008508.1\|WP_011670328.1\|2055851_2056592_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|180838
NC_008508.1\|WP_026131084.1\|2058126_2059596_+\|glycosyltransferase-family-39-protein	unknown	unknown	gnl\|CDD\|227621
NC_008508.1\|WP_002755464.1\|2068841_2069219_-\|hypothetical-protein	unknown	unknown	unknown
NC_008508.1\|WP_020381143.1\|2053600_2053948_-\|hypothetical-protein	unknown	unknown	unknown
NC_008508.1\|WP_011670333.1\|2066290_2067283_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NC_008508.1\|WP_011670329.1\|2056621_2058118_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NC_008508.1\|WP_011670323.1\|2047508_2049140_+\|hypothetical-protein	unknown	unknown	unknown
NC_008508.1\|WP_011670326.1\|2054353_2054671_-\|hypothetical-protein	unknown	unknown	unknown
NC_008508.1\|WP_002755443.1\|2061899_2062208_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_008508.1\|WP_011670334.1\|2067293_2068691_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NC_008508.1\|WP_011670336.1\|2072705_2073458_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NC_008508.1\|WP_011670337.1\|2073454_2074093_-\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NC_008508.1\|WP_011670324.1\|2052309_2053608_-\|[cytidine(C)-cytidine(C)-adenosine-(A)]-adding-enzyme	unknown	unknown	gnl\|CDD\|237339
NC_008508.1\|WP_011670331.1\|2062230_2065545_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226220
NC_008508.1\|WP_181742545.1\|2054820_2055561_+\|arginyltransferase	unknown	unknown	gnl\|CDD\|234939
NC_008508.1\|WP_002727159.1\|2059614_2060748_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022
NC_008508.1\|WP_002755428.1\|2053967_2054357_-\|ribonuclease-HI-family-protein	unknown	unknown	gnl\|CDD\|260011
NC_008508.1\|WP_011670338.1\|2074264_2074846_-\|hypothetical-protein	unknown	unknown	unknown
NC_008508.1\|WP_011670332.1\|2065541_2066294_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_008508.1\|WP_020780757.1\|2069866_2072575_-\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NC_008508.1\|WP_011670328.1\|2055851_2056592_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|180838	PRK07102, PRK07102, SDR family oxidoreductase.	4.3732e-64
NC_008508.1\|WP_026131084.1\|2058126_2059596_+\|glycosyltransferase-family-39-protein	gnl\|CDD\|227621	COG5305, COG5305, Predicted membrane protein [Function unknown].	1.23534e-12
NC_008508.1\|WP_011670333.1\|2066290_2067283_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	1.16633e-22
NC_008508.1\|WP_011670334.1\|2067293_2068691_-\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	1.42612e-18
NC_008508.1\|WP_011670337.1\|2073454_2074093_-\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.83386e-10
NC_008508.1\|WP_002755443.1\|2061899_2062208_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.45533e-09
NC_008508.1\|WP_011670329.1\|2056621_2058118_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.138e-44
NC_008508.1\|WP_011670336.1\|2072705_2073458_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	1.94945e-44
NC_008508.1\|WP_011670324.1\|2052309_2053608_-\|[cytidine(C)-cytidine(C)-adenosine-(A)]-adding-enzyme	gnl\|CDD\|237339	PRK13299, PRK13299, tRNA CCA-pyrophosphorylase; Provisional.	6.74956e-86
NC_008508.1\|WP_011670331.1\|2062230_2065545_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|226220	COG3696, COG3696, Putative silver efflux pump [Inorganic ion transport and metabolism].	0
NC_008508.1\|WP_181742545.1\|2054820_2055561_+\|arginyltransferase	gnl\|CDD\|234939	PRK01305, PRK01305, arginyl-tRNA-protein transferase; Provisional.	4.82659e-87
NC_008508.1\|WP_002727159.1\|2059614_2060748_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	3.17174e-47
NC_008508.1\|WP_002755428.1\|2053967_2054357_-\|ribonuclease-HI-family-protein	gnl\|CDD\|260011	cd09279, RNase_HI_like, RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD) residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Most archaeal genomes contain only type 2 RNase H (RNase HII); however, a few contain RNase HI as well. Although archaeal RNase HI sequences conserve the DEDD active-site motif, they lack other common features important for catalytic function, such as the basic protrusion region. Archaeal RNase HI homologs are more closely related to retroviral RNase HI than bacterial and eukaryotic type I RNase H in enzymatic properties.	8.6772e-54

>NC_008508.1|WP_002727159.1|2059614_2060748_+|glycosyltransferase-family-2-protein
MKKKNVTYVIPCLNEEKTLPLVLEKLARLKKELKQYNVEILVSDNGSEDKSISIAKKYGAKVVHCEERGYGAALNFGIKNASGEIVLFADADDTYDFLESPALLAEMEKGAEFVIGSRLDGSIHKGAMPFLHRYLGTPVINWIINLLYSKKGNRVKDANSGFRCFLKKKFLEWEIESTGMEFASEMLVKALRSGVKLSHVPISLYPDVEGRVPHLRTWRDGMRHLLQILIHSQQLFYYTGLILFWIGWAFTILGYFTGIVAIGPFHIFGIHSLTVFLLVATFGQTIWAIGLFLAARKTPELSFYSRLNLLSEDLLFWYSARMILFVILLFAFILFRWWKNSFQVLDLEKEILMISFLSVQILNLIGQTITAHLLKRT
>NC_008508.1|WP_026131084.1|2058126_2059596_+|glycosyltransferase-family-39-protein
MNRLNALLIEIKKDKVFLFLLGLGAFFRFFRLDLQSPWEDELFSIRASSETSFGNLWDWMKNDPHPPLYQTLLYFWFQLFQPTVFVGRLFSAIAGILVPFSFYLLSPHNLSGRIKTSVVVFLSLSTGLIYYSQELRSYSLLVLFSTIQLAILLKSVYENRKEKNLRIYWSLLGISLLASYTHFFGFIWSASIFLGIFITKWIFTKKFPKVEFYFGILFGILFIPVLYLLFNSDKIGIASWIPEAGFTAFLVFFDLIFHSGILKKFIPGIVASLALLAGFVSIYFPKNQMKTVALEPDHKKFVILLGIVFLIFSVVLGILSLIQPLITARNLLVTAPALYFLITTSFSLFPIYKGKRLESILILISIVSLYYFTRFYYKPFKEQWRESSQYIISTIQDRPLEFTLLCSSHTYNMEYFLKTAKIQGVVPKIYTKKEANLFVQDPTKKDLVILETSWKYLNSEDLDSLFAQKIFDRKDQLFYGMRVITIRKR
>NC_008508.1|WP_011670329.1|2056621_2058118_+|FAD-binding-oxidoreductase
MAKASKVSPKKKTSAKTSKTAKVKKSPIEITLPLPSKVETWGMNHYSLSPVFFPEKEEDFRDLFSYANNKGLKLTLRGGGCSYGDAATNTKGVVIDISKYNRILEFNSKTGIIKAESGVTIKQLWEFGIEKGYWPPVVSGTMFPTLGGALSMNIHGKNNFAVGSIGDHVLEFTFMTPNGKVFVCSRKKNRELFFAAISGFGMLGVFLNITIQLKAIYAGKMKVWPVVGKNLQDMFDYFEREYKSADYLVGWIDAFASGNSLGRGQIHKAVHLKKGEDPDFPENCKLERQNLPSTFLGIIPKSWMWLFMIPFANNLGMRLVNFAKFVSGYLTNNKPYFQGHAEYAFLLDYVPNWKLMYKPGSMIQYQSFIPKENAVDAFCEILKICQKRRIVTWLAVFKKHKSDPFLLTHALDGYSMAMDFPVTFGNRKRLWELAGELDEIVLKFGGKFYFAKDSTLRPETVQRAFPKKNLEKFYSLKRKLDPKGILETDLYRRITGTW
>NC_008508.1|WP_011670328.1|2055851_2056592_+|SDR-family-NAD(P)-dependent-oxidoreductase
MAKKIVVVGASSGIGKELAILLLEQGHTVTLVARRDKELKAIAAPFNSPGKTNAFVIKQDVTNFDQVDSAFQKAVKSMKGVDEIYYASGIMYDVKPDEFDVTKDIAMLNTNLLGCVAWLNLAAVLFQKQKSGKIIGISSIAGDRGRRGNPVYNTSKAGMNTYLEALRNRLSTLGVQVLTVKPGFIDTAMTRGMKGLFWLISAKEAATIIVKAADSGKECVYVPARWGLVGLIIRLIPSFLFKRLSI
>NC_008508.1|WP_181742545.1|2054820_2055561_+|arginyltransferase
MNSLPISPERSCSYYPDRLSQIQYLPLQGKIEKDNLQFFFDSGFRRTGNILYRTSCNACRECLSYRVPLNQFVPSRNRKRLLKKNSDLVVRFGSPHLTVEKEILYLRYQRSRYQSFVIGESDQELLEGMRWNLFGYPENSLEMTLSLDEKILGFMILDSASDSLSAVYSVYDPDYPDRSLGSFAILYSILYAKELGMKYYHLGYFLPGHPDMDYKKHWVPSEIRELDTNDWIPFEEFQKKYADFSW
>NC_008508.1|WP_011670326.1|2054353_2054671_-|hypothetical-protein
MHNLFTNFEVKKRGLRVALFFTIVSLICFLIENTILQFIFLGLGFVSFAFTLVQPEIFYSFTNRSLEFVLVFLSGIVKVGLLLIYLIVFKPIRFVIGLFLREKKS
>NC_008508.1|WP_002755428.1|2053967_2054357_-|ribonuclease-HI-family-protein
MISIFCDGASKGNPGPSSIGVVAYKGDKEEFRISERIGETTNNVAEWASLKKGLEECIRRKFDTIHAYMDSELVVKQVSGKYKVKHPNLLEYKKEVDKLLSSLQNFQITHVPREKNSVADKLANEAFQK
>NC_008508.1|WP_020381143.1|2053600_2053948_-|hypothetical-protein
MWRISFYVFLFYTASNCGRSLEDKLVVLQKEEKFEEMLLLCLSEKETQDTKELCRLAMEKTEAGIDRILSEKTELPYSQITVDPEWKKKIDIILENNRTLKNRYGNLWKKMIQND
>NC_008508.1|WP_011670324.1|2052309_2053608_-|[cytidine(C)-cytidine(C)-adenosine-(A)]-adding-enzyme
MTNVDPDELIKKIPENFREDIIRITQNIRKEGGECYLIGGSVRDLLLSKIPDEFDLTTSLLPDKILTLFKRTVPTGIKHGTVTVLIQDRSYEITTFRKDVDYIDGRRPEAVEFGVSLSEDLKRRDFTMNALALDLEAKRLIDEHSGLEDIQNKIIRTIGDPIERFTEDGLRPIRAIRFVSSLGFALESETAKAIIQCRNITAKISKERVHDELNKTLKSKNPAPSLKLFKEFRILELFTSLKLYPTENTNVEKKIREVPVVPLSLRLSFLHAWLFGSFQDRNSAKQFMKDLRYSNQNTKDSLFFSDMLFMMLNRKDDASLTDAEIRKAVLHPICVYAGRENLRILTEYILNLAYTYEPILKDIFDFRRILDLTERSQALVVTELALRGEDILRACPNLPPKQIGSVLEKLLFHVLENPDENRKDFLFPLLFK
>NC_008508.1|WP_011670323.1|2047508_2049140_+|hypothetical-protein
MFNRLIFSPYFRYFIYLFAVLFLIFNRFKLDDKVPFVSSDSEIKYYQTIMFFEKGFKAVAESECLYPGKIYDPEFRYFPFDYPWAFLKENENRKCIFQYPPLFALLNGIPAYFFGAKIITLLPLLYLFGCLLIFDKILSLFIDKTWVILIGTLVPFTLSFPALSSVEFSEVPLNNFLLLSFGYFLIRSLFADKITVQNKNLNSNFRIFSFISGFLAVTAFFLRTESAFPIFLFGFLAFFSQKTRNNLKEYLIFSVPGGVLSFGFIGVLNFFYSGHPMGIRFLVSSQDAMSQFSIGKQIVILEGYLLGDATKSGFLKASPYAILIFGIFSDLIRKKELSGGSILGLVGIGTLFSISFFSPYTAGVHHFGLRYLESGFVFLSAGILIFLYQRNIEFPNIGRVLILLTFLSLYYNYKFTREGFKILFGSIAPYLQIQNEFQSKRIIVHKGQFTNYLIGYSYLNSLHFTVYTEKDAIQLEQTFKKNRVDSYSILEYEPEPPKDPNLPEKQFKEKIAVRFPDPNRYYRVKDQKKILNFSLRTYQLYKN
>NC_008508.1|WP_002755443.1|2061899_2062208_+|helix-turn-helix-transcriptional-regulator
MFKSLHSREAKIFCKNLIAARKSADLTQLEIAKRLGEPQSYISKIESGERRLDVIEFWRIYKILGKSFEFYFQFDEKPEGSEKRSKTLKAASGKRKKKRSKF
>NC_008508.1|WP_011670331.1|2062230_2065545_-|efflux-RND-transporter-permease-subunit
MIRGLIEGVLRFRLATLIASAAAIVFGIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVSVRRSRTINGLVVFQFVFEDGTDDYFARTRLLERVRDADIPAEIQPTLGPMSSPVGEIFRYVVETKANHTPMELRTIQDWVIMPKMLGIPGIADVVTFGGLPKQYHVVTTPDKLIRYRLTIDDVIKAIQQNNLNTGGNLLLQGEQGFPIRSLGAIRDPKHIENIVVKTVNGVPVFIRDLGTVEISHPIPSGVLGYTVQNDQEGLIDVDSSVQGLVAIRRWGDPNIMGDRIRDKVKEINENYLPEGVQIRTTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLLSLGAIDFGIIVDGAVVMVENVMRRYRDASPVDKKKGIIRFTVDAASEVGTEIIFSILIIVLAYLPIFSFERIEGRLLKPMAFTISFAILGALIFSMTAIPVMMSYIYRNYFESPNPGPIEWHNPFYEWLEKKYERLIEWLVDRSKRVVTICFSVVGTLLVLGGLSLGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIRQIIYKNEQVNVVLSQLGRNDDGTDPLPPNRLEVLVGLKDYDDWKEKITKTELLLRMRNDLEAGLPGARVSFSQPIMDNLSEAIMGTIADLAVFVSGNDLKVMRQISTEILDIVKEMKGASEYGIEQEADSPQLTVRIDREAAARFGINVSDIQQMVEAAIGMQRIDTLYEGPSDIPPKTPARFGIVVRFSKDYRTSQRAIENMPIISPKGERIPLSELAKVTLEDGPTMIFRQEGRRTVTVRTNIRGRDQGGFVAELRKLVDKKVKLPEGYEVRYGGQYENLARVGTRLAMVIPLTIAIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLMRGYYFNVSGGVGFISLFGIATMAGVLFVSRTNHLLHEDDEISVKEAVKKAAVIQLRPMLMTMLLALLGLIPATLASGVGSDVQRPLATVIVGGLFSALFLVLTVLPSLYLILVGEREYVPKKQKDLEPYSYLDQYPLEEYESKEFDLSTETKKTISKKKQKSSGSKKKKKE
>NC_008508.1|WP_011670332.1|2065541_2066294_-|hypothetical-protein
MKQFKFLVLLILLGFLNVSILAQSQNPKYDSNSKDDSSPEWTDDPDRKTKFGKEEEGGDILKGKPLPKSTNFLVYGVSIGSPGSINLNLGYYYKDVVVRISGGKWNPHWWGGQVDIGYNFWKTPVIAHSISLVFGRFEVDPFEAELGRGGQTRYPSGSSFPGYTHRDPTYEDLIIRSYVTEQSPELALYLERESRDRQKVHLNQQYVGLTYDFLLGNFFLQVGGGIGKGDYKNPQLLIQVGYLFDTRSAE
>NC_008508.1|WP_011670333.1|2066290_2067283_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MKIHFTRRTLLIAGAAAVIAIVSIAILALSKKNKQSILPPSKAIVHDKGEWIEFKENSPGLEIIKTSQIGKEGEFVEVEAPARLIASTSPSMSGGEKIILFESADLNDLYVGYIHSKNSLNRSRKNLERIKDMFKHRVATEKDLIEAETNAAELAEFEGKLRAVGLNPNELRGAGAQSAWIICDVPESQLQSLKKGKKVNLKFSSFPEANWVGVAEALGDNVDPMTRTVKVRILIRNENYVLKPGMFATVRFPEDRKGDTVIVPFTSIITVEGKNYVFVEEAPREFYKREVVLGTSGEDRVTIVEGLTKGDKVVVERNHLTQRTQLRFLT
>NC_008508.1|WP_011670334.1|2067293_2068691_-|TolC-family-protein
MRKIFTFLLLLWMVPILSEGGKTGADPGLGIPESPNQSENPIQREVVATPDKERTLDLKTAEEKLWKNNLLLLASRFNIDARKAGIEQAGLYANPNIFIDQSIYAEPTQRYFDFTRSGQTVVQIQQLFLLGGKIGKRVRVAELNARMGEQEFYDLARELVTKLRKLFYAIYYYRQAISFYDQSLEALGRTVTSAEMGYKRRAILQAEVLRLKALYFFLKKEREELNIRILEREADLRVLLNDDSFRSSDVKIVPMIVENQLDNLEPGKLKRDELLELARNKRPDLKKAIQALRYEEANLELQHANAIPDLAFGPMYNRGGTAFQNYWGITAQLNIPIFDRNQGNIKASEKAILSRKQELKNTLLEVENEVAVSIETARLKDELYKKFRNTYTKEYTDLSKDMILSYEKRYITISEFTDFFETYCSSVVEMLKLQTDRMDAIEGVNFSVGQGVLIPKFSDPVTEEK
>NC_008508.1|WP_002755464.1|2068841_2069219_-|hypothetical-protein
MKVRWIHRFLILVLTTVIVLPCEEDGTFDLAFLDVRGGEIHFALAKKIQNQSHRKTRSEIQSGIEARDLVVCLRGRYDFLDLVFSGFFELSKTEVHFFSGKFSAPKTHFSYLLSSLLLNLPPPTA
>NC_008508.1|WP_020780757.1|2069866_2072575_-|preprotein-translocase-subunit-SecA
MIQNILRVILGSKFERDLKKLIPIVGQINSLEKEMKETSDSLLSSQTQKFRERIARGESLDSILPEAFATVREVSLRTMGMRHFDVQMMGGIALHRGNIAEMKTGEGKTLTSTLAVYLNSLAGKGVHVVTVNDYLAKRDANWMKPIYDFLGISVGVIQHDMDHEQRKIAYSADITYGTNNEFGFDYLRDNMVSHKDHKVQRSHFFAIVDEVDSILIDEARTPLIISGSSDETTDKYVRINKIIPKLVAIEDFEVDEKARNVLLSEKGVSHVEEILGIENLYAPENVDLVHHVHQALKAHKIFQKDVDYVVQNGEVIIVDEFTGRLMAGRRYSDGLHQALEAKESVTIAKESQTLASITFQNYFRMYDKLAGMTGTADTEAEEFRKIYDLDVIVIPPNVSVRRKDSPDRVYRTEKEKFDAILAEIRELQSKKQPVLVGTISIEKSEILSKMLSSAGIQHNVLNAKFHEREAEIVANAGKPGAVTIATNMAGRGTDIVLGGAQLYKENLETWKDDDDLVRRFKESILKQELDNAELLIREMDSSVKQKRASEILESVKIWKKNHEDVLVAGGLHILGTERHEARRIDNQLRGRSGRQGDPGSSRFYLSLQDDLMRIFGSDRISGLMKWANMPEGQEIESKMVSNAIARAQKRVEGHNFDIRKHLLEYDDVMNRQRIVIYKMRNEVLENEDISSLILSFIEEAVENQIVAHCEGNNPSSWNLDSLKEWLEGLELNLEINEEDFKKTKNPQLALFEKVNAAAKQKYEDRAESIGKDIWKLLERNIFLDILDHRWKEHLYSMDHLREGIWTVGYSERNPLVEYKLQGFRMFDVAIENLKNEVVNFLFRVEVSENSKLPEERREYKKVGQEVTGGFQELSSGTPSPTVTVTTSSGGGTERKTSRRRKR
>NC_008508.1|WP_011670336.1|2072705_2073458_-|type-1-glutamine-amidotransferase
MRSLIVRFKDCEGPGILLDSLKERNYKITYHNAYDSRVRPFPDAHLVFDLVVLLGGPQSVTDPTLVPFFEPWLNLVRYTASMPNRKVIGICLGAQIISKALGGEVRRGEKGPEVGFYDVQVQEPTHLVFDGITSFPAFHLHEDIFSIPQRAKHLLKSEMYSNQMFSFQDRIFGIQCHMEVTASMLKVWRVVHSDFIRSWVPGPDTEILRSQMENVGRRVFAAILDLTPDSTVDRSAFIPQSPDFVAAENG
>NC_008508.1|WP_011670337.1|2073454_2074093_-|TlpA-family-protein-disulfide-reductase
MNSEPHFRIISSFFLGSYIYLMNRILLCFVFCILTVHCTLSEQPNLGIYEFQGITLDGTLVRLSEVEAPRLVLNVYGPNCVPCIKEIPALNYLYQDMQKDPKIQFYMAVDPTLFFDEAETMSEEELLTKGIFLVKEEIRKYGIQVPTLLMKKPFRVSRTGSIVTGTPETLLFKTKPFVLYYNFIGPISEEENPQRLSVDQKVLFFKRMAGSS
>NC_008508.1|WP_011670338.1|2074264_2074846_-|hypothetical-protein
MFRISVKHNIVPFAFLFHLLSFSGACVPVQLEITSVTLCDHFNRSGECLEPVEKDHHYKVEIPHIKKPDTWEKFANYLYFHARETPGFLIRFNRKLTPSESRAIQDSYYATMSFSGTVERMEGFEIGEDWIGSFQYLGSIIKNKLKKENRLGSYPYTNMIFPAEVEFKFDSSLFEGGEKTKINLSYIVLPPEK

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Crispr_ID: NC_008508_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008508_2

3027887-3027994

Orphan

Consensus_repeat	Method
CCAGCAAGTATCGGTATAGGAAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008508_2

>merge|NC_008508|2|3027887-3027994|CRISPRCasFinder
CCAGCAAGTATCGGTATAGGAAGTTCTAGCATAGTAATAACCTACATTCCACCAAACACTGGCACAACAAATTCCCGTCCATCGCCAGCAAGTACCGGTATAGGAAGT

>NC_008508|2|2|3027887-3027994|CRISPRCasFinder
CCAGCAAGTATCGGTATAGGAAGT	TCTAGCATAGTAATAACCTACATTCCACCAAACACTGGCACAACAAATTCCCGTCCATCG
CCAGCAAGTACCGGTATAGGAAGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008508.1\|WP_002755129.1\|3035911_3036430_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237855
NC_008508.1\|WP_017860175.1\|3036428_3036620_+\|hypothetical-protein	unknown	unknown	unknown
NC_008508.1\|WP_002728351.1\|3015069_3016104_+\|putative-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|200393
NC_008508.1\|WP_002755157.1\|3016153_3017692_+\|spiro-SPASM-protein	unknown	unknown	gnl\|CDD\|275125
NC_008508.1\|WP_020780498.1\|3038146_3038851_-\|hypothetical-protein	unknown	unknown	unknown
NC_008508.1\|WP_002738770.1\|3029974_3030769_+\|hydroxyethylthiazole-kinase	unknown	unknown	gnl\|CDD\|236477
NC_008508.1\|WP_011670877.1\|3017666_3019241_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133011
NC_008508.1\|WP_011670879.1\|3022730_3024011_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|184327
NC_008508.1\|WP_011670885.1\|3037255_3037672_+\|globin	unknown	unknown	gnl\|CDD\|381254
NC_008508.1\|WP_002729738.1\|3019758_3019983_-\|hypothetical-protein	unknown	unknown	unknown
NC_008508.1\|WP_002728353.1\|3024014_3024860_+\|hypothetical-protein	unknown	unknown	unknown
NC_008508.1\|WP_011670878.1\|3020092_3022741_+\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235582
NC_008508.1\|WP_011670882.1\|3031612_3032056_+\|host-attachment-protein	unknown	unknown	gnl\|CDD\|370820
NC_008508.1\|WP_011670887.1\|3039485_3040445_-\|hypothetical-protein	unknown	unknown	unknown
NC_008508.1\|WP_017860174.1\|3036627_3036855_-\|hypothetical-protein	unknown	unknown	unknown
NC_008508.1\|WP_011670875.1\|3012933_3015009_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NC_008508.1\|WP_011670883.1\|3032544_3034092_+\|glycerol-kinase	unknown	unknown	gnl\|CDD\|212665
NC_008508.1\|WP_011670874.1\|3010664_3012749_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NC_008508.1\|WP_020780505.1\|3034764_3035778_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_008508.1\|WP_011670880.1\|3024924_3026028_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799

Protein	Function_ID	Function_description	E-value
NC_008508.1\|WP_002755129.1\|3035911_3036430_-\|hypothetical-protein	gnl\|CDD\|237855	PRK14900, valS, valyl-tRNA synthetase; Provisional.	1.14471e-07
NC_008508.1\|WP_002728351.1\|3015069_3016104_+\|putative-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|200393	TIGR04142, PCisTranLspir, putative peptidyl-prolyl cis-trans isomerase, LIC12922 family. Members of this protein family have a known crystal structure (3NRK) showing similarity to the peptidyl-prolyl cis-trans isomerase SurA. Members are found in Leptospira species next to an uncharacterized radical SAM enzyme and a cytidylyltransferase family protein.	8.85711e-105
NC_008508.1\|WP_002755157.1\|3016153_3017692_+\|spiro-SPASM-protein	gnl\|CDD\|275125	TIGR04321, hypothetical_protein_TresaDRAFT_0163, spiro-SPASM protein. This three-domain protein is restricted to the spirochetes and widely distributed (excepting Borrelia). It has a conserved C-terminal SPASM domain, a 4Fe-4S binding domain shared by a number of peptide-modifying and heme-modifying radical SAM proteins. It has a central radical SAM domain, although half the members have lost the signature 4Fe-4S-binding Cys residues, fail to register with the radical SAM domain definition of pfam04055, and must be considered pseudo-SAM proteins. PSI-BLAST shows a relationship between the N-terminal domain and various predicted glycosyltransferases (e.g. Bacillus subtilis SpsF) and cytidyltransferases. In some Treponema species, this protein appears to split into two tandem genes.	0
NC_008508.1\|WP_002738770.1\|3029974_3030769_+\|hydroxyethylthiazole-kinase	gnl\|CDD\|236477	PRK09355, PRK09355, hydroxyethylthiazole kinase; Validated.	6.75731e-123
NC_008508.1\|WP_011670877.1\|3017666_3019241_+\|hypothetical-protein	gnl\|CDD\|133011	cd02518, GT2_SpsF, SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat. Spore coat polysaccharide biosynthesis protein F (spsF) is a glycosyltransferase implicated in the synthesis of the spore coat in a variety of bacteria challenged by stress as starvation. The spsF gene is expressed in the late stage of coat development responsible for a terminal step in coat formation that involves the glycosylation of the coat. SpsF gene mutation resulted in spores that appeared normal. But, the spores tended to aggregate and had abnormal adsorption properties, indicating a surface alteration.	1.59811e-68
NC_008508.1\|WP_011670879.1\|3022730_3024011_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|184327	PRK13789, PRK13789, phosphoribosylamine--glycine ligase; Provisional.	0
NC_008508.1\|WP_011670885.1\|3037255_3037672_+\|globin	gnl\|CDD\|381254	cd01040, Mb-like, myoglobin-like; M family globin domain. This family includes chimeric (FHbs/flavohemoglobins) and single-domain globins: FHbs, Ngbs/neuroglobins, Cygb/cytoglobins, GbE/avian eye specific globin E, GbX/globin X, amphibian GbY/globin Y, Mb/myoglobin, HbA/hemoglobin-alpha, HbB/hemoglobin-beta, SDgbs/single-domain globins related to FHbs, and Adgb/androglobin. The M family exhibits the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments (named A through H). In Adgbs, the globin domain is split into two: helices C-H are followed by helices A-B and the two parts are separated by the IQ motif. Although rearranged, the globin domain of most Adgbs contains a number of conserved residues which play critical roles in heme-coordination and gas ligand binding. Adgbs have been omitted from this A-H helix cd.	9.95615e-05
NC_008508.1\|WP_011670883.1\|3032544_3034092_+\|glycerol-kinase	gnl\|CDD\|212665	cd07793, FGGY_GK5_metazoa, metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases. This subgroup corresponds to a group of metazoan putative glycerol kinases (GK), which may be coded by the GK-like gene, GK5. Sequence comparison shows members of this group are homologs of bacterial GKs, and they retain all functionally important residues. However, GK-like proteins in this family do not have detectable GK activity. The reason remains unclear. It has been suggested tha the conserved catalytic residues might facilitate them performing a distinct function. GKs belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.	0
NC_008508.1\|WP_011670878.1\|3020092_3022741_+\|valine--tRNA-ligase	gnl\|CDD\|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0
NC_008508.1\|WP_011670882.1\|3031612_3032056_+\|host-attachment-protein	gnl\|CDD\|370820	pfam10116, Host_attach, Protein required for attachment to host cells. Members of this family of bacterial proteins are required for the attachment of the bacterium to host cells.	7.34406e-35
NC_008508.1\|WP_011670875.1\|3012933_3015009_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	3.96475e-57
NC_008508.1\|WP_011670874.1\|3010664_3012749_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.54061e-58
NC_008508.1\|WP_020780505.1\|3034764_3035778_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.02392e-13
NC_008508.1\|WP_011670880.1\|3024924_3026028_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0

>NC_008508.1|WP_011670880.1|3024924_3026028_+|peptide-chain-release-factor-2
MEVKSAKELKRVSKELQENFLNRWKLLNLEQDKDRLKALNEKSEDPDLWNNPEEARIVSQKKNELEKKLTPWFTIQQDILDFPDLVELTLDEKGENGIGELSMEYNRLQEKFEELELLGALKNSEDLKPAFLNIHPGAGGTESQDWAEMLLRMYIRYFEKKGYQYSLIDIQAGDGAGIKNVTLHVVGDFAFGFLKGENGIHRLVRISPFDANKRRHTSFVSVHVSPEIDDEIDIKIEEKDIRVDVYRSSGAGGQHVNTTDSAVRITHLPSGIVVACQNERSQIKNRDTAFKMLKARLYEMEQEKAKEELEKKSGEKKDIAWGSQIRSYVFHPYNLVKDHRTDHETGNVAAVMDGDIEPFILAYLKTL
>NC_008508.1|WP_002728353.1|3024014_3024860_+|hypothetical-protein
MPFLISGNLDLVERHSLKKMEKFLGIILSPVQFPVEQYNLLRHALHRNLDPDTLIRKMNRQELLSFIYILTQFGDVVRAETPVEYLDVEKIPLVLEWQKGLYMIPYEVLDHLSTSRIFKNQNYLFALIPSLPVKEKKAWIEWIGSGYGKTFPREINHELYFQCRHLQKPFQGKSLLREETIQLNQLWPSGKNEIVDWFHKGITPFYSAMKELSRTEKDPFLLHILDLIRSGKLILKKNPEEFRKKEEYILVATVEGNTPQLRDTVFSWEQERENKEDFLFQ
>NC_008508.1|WP_011670879.1|3022730_3024011_+|phosphoribosylamine--glycine-ligase
MQVKLKVLLIGSGGRESAIAFHLRKSSLLSELKVFPGNGGFPDNEILPSDSFNILSKESVQSFLKLNPFDFIVVGPEDPLVAGFADWAAELEIPTFGPDSYCAQVEGSKNFAKSLMVEANIPTAVYKTFTEYSASLNYLESQTVPIVIKADGLAAGKGVTVATTKKMAMNALKEIFKDKKFGESGNQVVIEEFMEGQEASIFAVSDGDSYFLLPAAQDHKRAFDGDQGPNTGGMGAYCPAPVITETILQKVKEKIFDRMFETFRKKGHPYRGLLYAGLMISPDGEPKVVEFNCRFGDPETQCVLAMFDGDLLELLYIASTGKIKEVRTSIKSGAATVVVLAAQGYPDSYEKNIPLNLPETSGQNVYLFHAGTSKKDGKVFSSGGRILGVVAQGTDLRNSVDQAYSFLEKIQVPKTFYRKDIGHKAL
>NC_008508.1|WP_011670878.1|3020092_3022741_+|valine--tRNA-ligase
MKKQIGDRYEPKEVENKWISLWEEKKSFAPNSNSKESFSMVIPPPNVTGSLHIGHALNHTIQDILIRIERKKGKSTLWLPGMDHAGIATQMVVERELAKEGKKRTDFTREEFVNRIWEWKDHSGGMITRQQKLLGESVDWSRERFTLDEGLSKAVFKVFKSLYDEGLIYRGERIINWCPASRTAISDLEVEFRETKGKLYHIKYPIHGKKNQFLVVATTRPETMFGDVAVCANPEDKRYVSFKNVVLDLPLTNRQIPLLFDSFVDQEFGSGLVKITPAHDANDFEAGQRLGLKPLLVMNPDGTMNVNAGPYQSLDRFEARRKVVADLEVKGLIEKIEDHVHSVGHNSRGGTVIEPYLSTQWFVKIKPLADLAVEAVQTGQVEFIPKMWEKTFFEWMHNIRDWCISRQLWWGHRIPAYHCKTCKHVEVSETPVTACPSCNSKEVEPDPDVLDTWFSSQLWPFSTMGWPEQTPDLKKYYPTSVLVTGFDIIFFWVSRMIMMGMKFLKAPPFHKVLIHGLVRDKDGKKFSKSVGNVIDPLVMMEKYGTDSFRFFLAATLPEGKDILFDESRLDGYRSFCNKIWNSSRFILMNLKESFVPTGITSEIEKDLEPMDQWILSRFNRCLEEYNKAHSKFHFYEMAAAIYEFIWGDFCDWYIELVKPRAYGKVSPRSTEVAKQVLSDVLIRALGLLHPFMPFLTEEVHSVFSNQYIVTTPFPEAYPISYDAAGVQKLNLLQEIVTKIRVMRSENGIAPDKKCKTIVKSEDDITRLTISENEISLLQLARLESIRIEATYEIQKTDSVSHFTKGEIILPLEGLIDIEKEKARLNKELQKSEVEKEKLEAKLSNPGFLSKAAPDVVEKEREKLKIFTDKVEVLKKGIQNLAS
>NC_008508.1|WP_002729738.1|3019758_3019983_-|hypothetical-protein
MNLHSKKVRKVRMKILLLRVRRLYGRHSFKLSETVFGCGDGPGNVFLKTDWPGSIQLIGGILYRIDARILGKDS
>NC_008508.1|WP_011670877.1|3017666_3019241_+|hypothetical-protein
MSGIRSTRNIYAFIQARTGSARLPGKVLRELPSGSGKTLIDRIQDRIRVVLPEEQIVYLIPEADQELRSFLENRKYRFFTGDPLDVRLRYIKAAEFFKAEAILRLTGDNPFYDTLHLDQLLQSFQFTKPDLAYVTELPLGMGGEIFTRKALEWCPQVLEERHKEHVSLSIKENPHRFRITKLSSLLTEKEKQVLPKLRLTVDEPKDFETVSRIFNLLNDRNPFFGAKECIQLFEKEPNVFVGNQDVEQIRFQTQSTKMTNQFRVGILVGDPKKFGSGHFERSRILFALLSAASYKTFWLEDFPADGELDLLVVDSRDIPIPEYSKTRIFLLDHFGPDRKKYGHYDLLPHPTISDRFSLDRILISPGLLNVDPISNSFLLCYAGSINSSKELDFFLSSLLSKDKSLSQIVRVGGAPPVGNSIEFIPRVSRFQFQNLLASCSGFVSYFGQSLFEAVFLKKRICSYSISPIHSSLARFCEQKFGIPFAGELSSGGLDSNTEPSVAFQSVSGEGYSLLLREIEEFLHS
>NC_008508.1|WP_002755157.1|3016153_3017692_+|spiro-SPASM-protein
MKFPIFHSAVFLSPETTSLLESASEGENLLFLSLRKLSKVLPESTVFFNAWPFPKRINTYNFLNIRILEDPSEISFVKKISSELPQSRTGDPDWDDASFFYFTGLFPCLDENLSLEIYRRHDLYLSQYSYSENLPSGIIPTILSREFTNGIPEAANTSVQEYLGKNINHYDVEIFYHDPDLRQYRLDFSLKNKRSLNLVRGFLKSKEEWNYSDIHPWIQRHPEVFRTGPSYLELEVYRGCELSCSFCPRQFSSNDQDGSFLSPAFLENLLKQQEESFSNEYGVCFGGLGEPLLHPEFTKLLSTVFQISSPLLQELFIETALYTDLNSTLDFLNTLDSSFRQKITWIVNLTTRNQEKYNSLYGKKVLSRVFSNLEQLGNIFPKNRIYLQFLKIQETENEVEVWVDETEKQGYGVILQKYNRYAGLMPEKRVTDLTPIQREFCWHLNRDLYVNSDGTVSICKQTPGKVFGNLHKETLMQIWQKGLPSFADSLNGKHETTGAPCLNCDEWYTFNA
>NC_008508.1|WP_002728351.1|3015069_3016104_+|putative-peptidyl-prolyl-cis-trans-isomerase
MNSKQTYAKNFFFTGTFVFLFLQNPIQTAESLNRVIATVGTISISELDLDDASEKYTKLQKHLKHEDFRKSLRTRIIDFLIDRAIVDVVAEEESIQVNEQRVDAEIEKRMEVMGITNRKQFEKAMETSSGMPFELWVTELPYQIKKGQLLQLKIAVPPPSEQEIKSWYNQNRDKVGFEIRYRIISIAPENDSIQEENRLYKELSDIRKSVLADPSSFALIAGSPRNDPTLRSRRGMVEWISSFDLYKYSKITATIAAPLPNGGVSEVFRDERKRYSILKIEGKRPTPMENLRGGIQNILYRDKEEDTFYRWLKESRAEIPIQIFDEAYRKENKIPLKEETFHLD
>NC_008508.1|WP_011670875.1|3012933_3015009_+|methyl-accepting-chemotaxis-protein
MSIRFRISLYLSIVLFIGFSILAAINSITTYRNLKSEVENNSTITSERWSLEVKDILDSAMFYARGFRSPLIFTSPPREAVITSIKEVIERNPNFFALWLVYEPDLYDGKDAQYRNTFGHDSTGRFVPYAFQSGEKGKARIRPNVGYENQDGTGDFYQVPKKNNTYYVSEPYRYKSDNIDTMMISIVAPISKDGFFRGACGIDLKAEELQKKFGEVKPFRNQGYMTLISPSGLYTVNGKDPSLIGNKIPDAQELEFYLKKSQEGKNFTYSSEAHTHYFFPFHVGKDKRFWTLQVSIPDSIYTDAMFNTIFSRALTATLILVSVLLCVNFIFQRLISAGLLKAVGFSEEIASGNLVAQSSHGKKDEIGTLLGSMNQMRESLLKVLREISGSAKMLRDTSEKMADSSRNFSDVAQTQASAAEESSAAVEELAASAQNVGKSMEKAVLSMKEIDGNVVRLKEQIVNINREMQDLVELAALSKEQGVTGENAMIESTSAMAAIGDSASRITEILSIITEISEKTNLLALNAAIEAARAGEAGKGFAVVAEEIGKLASQTSSSVQEIGSLVNSTNTAVLNGNTKVAEASNVLKKLREQVEEFDRYAKNVLASVKTQEENTKEISQSANELMTFSLQIEEAVLEQKRATDEITKTIMSISDGTQEIASGADDLTSFSGNIHGQAQNLGQLIGKFKTD
>NC_008508.1|WP_011670874.1|3010664_3012749_+|methyl-accepting-chemotaxis-protein
MSIRFRISLYLSIVLFIGFGILATVNSYTAYKKLEQEVVNGSEVTAERWTMEIKDYLNTGMGIIRGFRFPLLFDSPPRNKVILALQEILKVNESYFGARVAYEPNGFDGQDSQFENTPGHDASGRFIPYLHRGKTDEEIVLEAAKYYDNPGPEGEWYQVPKKTLTQFVTDPYYYELDGKVKILMISLIAPFRVGNQFYGVGGLDYRLEELQKLIGGKKPFQGQGYLSLISPKGIYAVNGFDGNLVGKQIPDAQELAFYLKESQEETGKKFTTDSNGYTHYFFPFHIGKDKRFWTLQVSIPNSIYRAAIMSILFQSFVATILILLSVLLCVNFIFQRLISAGLLKAVGFSEEIASGNLVAQSSHGKKDEIGTLLGSMNQMRENLLKVLREISGSAKMLRDTSEKMADSSRNFSDVAQTQASAAEESSAAVEELAASAQNVGKSMEKAVLSMKEIDGNVVRLKEQIVNINREMQDLVELAALSKEQGVTGENAMIESTSAMAAIGDSASRITEILSIITEISEKTNLLALNAAIEAARAGEAGKGFAVVAEEIGKLASQTSSSVQEIGSLVNSTNTAVLNGNTKVAEASNVLKKLREQVEEFDRYAKNVLASVKTQEENTKEISQSANELMTFSLQIEEAVLEQKRATDEITKTIMSISDGTQEIASGADDLTSFSGNIHGQAQNLGQLIGKFKTN
>NC_008508.1|WP_002738770.1|3029974_3030769_+|hydroxyethylthiazole-kinase
MPKHSALERAWPAKEIVEDLLELRKRSPLTHIMTNIVVTNWTANVLLAVGASPAMVIAEEEAGEFVKIANGLLINVGTITSNDAKAMKIAATVAHQTNTPWVLDPVAVGALGFRTETTKKLLDLKPTVIRGNASEILTLAGIAGKGKGVDSTVNSKDALPYAQELSGKTGAVVAVSGEVDYVTNGKETIEIYGGDPIMTKVTGVGCSLGALIASFLGIQKDPLRASASASAVFAIAGSRSAKKSNGPGSFAINFIDQLSQLSIE
>NC_008508.1|WP_011670882.1|3031612_3032056_+|host-attachment-protein
MKNKWVVVANRSEAKIFEYKGSRKGLELLESIENPKGRMKNRELIPNSSGRGKRAKAQKIAFDTKSVQEPKRRVAESFASQISAVITQGRKSNRFLSLVLISEPRFLGMLLDKMDRKSQSMIFHKMGKDIITTNNREILSHLREILV
>NC_008508.1|WP_011670883.1|3032544_3034092_+|glycerol-kinase
MTNPQGKYVLSIDSGGSGIRAFLLDRKGKITERQYEKTPPNIPEAGALEHDPEILWKSLLILLKKIQKNKQITKEIAALGICNQRGSFLLWERFSGKPLTPLISWADVRSHKTAEAMNRNPIWKTIRFVSTLVGRLTNHPMMIATSMLRFTTDHATCRLKFVLDENPELKRRCKKGEVLFGTLDTWFIYKLTGGKQHLTDSSNAVATGMFNPFQLIWNQPILTIFGIPANLFPEVKDSNGDFGHTLPEFLGGHSVPIRASIGDQMAALFGQCCFEPGEVKISQGSGAFVDINIGLKAQLSKRGLFPMIAWRIDGKTTYMLEGYVATAGTLIDWLGKGIGLSDTPKVLNELAAQAEDTEGVVFIPTPTGARFPYFNPRAKASVIGLSLASHRRHVARAVLEGIALSLYEILEGIQQDTKIKIKDIKVDGGVSQSDILLQCLSDFSNVRVDRAPEPDMTATGAAYLAGLSIGFWKNLGELKSLQKGYKSFEPKMDSTQRAQKIQRWKKAVTATLFIE
>NC_008508.1|WP_020780505.1|3034764_3035778_+|alpha/beta-fold-hydrolase
MMKKNKMMKLFKWTLGFLGIFALFLIVTFYAETPKYEYKVVPLHPDFGSYYHEKLQISRTKKARPDNEEKLVRYSQGKTEFAVLYIHGFGASRAEGEEVTDQLAKDLKANLYYVRLPGHGTNLEDHRDTTFAEIIQDSETAFLEFEKLGKKTILIGTSMGGLICTYLAAKYPEKVHALILVSPFYDFTSPWGGIYQFSWGKNFAHLVMGKIRKSTQEQKQDPASAFWYRDQYLAAVQNLSDLREYILGTNPFSKITSPVLLFYYYKNEQEQDKSASVPSMLNAFGKLNHNGKASPFNKAVKVETGDHVLFSKYMKSDKDLILKETKEFIQKVFLLKR
>NC_008508.1|WP_002755129.1|3035911_3036430_-|hypothetical-protein
MSLFLFETFSDNFQIKHKEVTSGKWFGLNSLNLEGKPFATFFEGDLVLKLGAEKIAEVISRYPGAKLFDPSHNNRAMKDWLQIPVEFEEDWLSLAESSFLLAQKTLNVSLPAKKKSAPKKAAKKKTPAKKKSAPKKKAVKKKSSAKKTKVKPKTTAKKKVARKKAATKKRKR
>NC_008508.1|WP_017860175.1|3036428_3036620_+|hypothetical-protein
MHQEESFSFSFQEINLIVSPTGRQQHAWVIFEKAYVIERPIGMAYPGPKRRIKFSKKTDKFRE
>NC_008508.1|WP_017860174.1|3036627_3036855_-|hypothetical-protein
MWELSRKLDNNKTYSKIDDRQKGRELPFYEKFKMNISVEVLRPALTHLYIIECLKFFIKRGIYAQINGTLFYRDQ
>NC_008508.1|WP_011670885.1|3037255_3037672_+|globin
MNISENLIRNLNESFDIINLDRIKFAEIFFVYLKEKNPKFENIFSKIQLEEAKSFMNSARNIALSGVQNVQLEKAIQDFKMECIKICNRTEEIPLLEKAWLFALEEWLGPWYSHKVEESWQKIFQMLYSEETTLQWSR
>NC_008508.1|WP_020780498.1|3038146_3038851_-|hypothetical-protein
MLFLALLFSNCANKNDDKSLNNALLLAALQQKDPGTAGAYAALSILSANNNPGKQGAYSRGNASPFAVINQSQDCASGGKMTLSGDYTDSQTANGFSMRYTGTKMTFENCQQMAPSMQGSGTSLFTIQGEITLDGRADIVMDGNFNPNAPVTELKYTLNSTQRMHSSSYTVNGFLYPKMDITFTSNNAKYSFQNMDDIDKTTITIEETVEISGTIGEEKIKDSHTYKSTIKLKP
>NC_008508.1|WP_011670887.1|3039485_3040445_-|hypothetical-protein
MLPSDQKFLPFNFKLHFSITRIRKITDRSAKMFPPKLDGMLLYVLFFVSICFFTNLDAKSILLKNERKIVNVEIKTVPNGFEITHKNGKVERISLAEVQKVFISNFPPNQTKKPEVSKTPLNIEANQEQIAPLRQTETPEAAKTIPKLEANLDERVSSAKKSGIKIFAEGLIPGWSRLLRNDSYSLKGLGFLLILAELYLAERSYLYLSPVKSALKTNSPPTPFELIAIASNDPNLINIAAPYSIVSNSSKVVLMDGQLMEKSRYAYEKQAYVSAFVFVLILDAFLGYTFENWKVIPSVNVSFRDQEIKEISGGLIFHF

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_008508_1	1.1\|2060808\|29\|NC_008508\|CRISPRCasFinder	2060808-2060836	29	NZ_CP014852	Bacillus thuringiensis strain HD12 plasmid pHD120161, complete sequence	43605-43633	8	0.724
NC_008508_1	1.1\|2060808\|29\|NC_008508\|CRISPRCasFinder	2060808-2060836	29	NC_018487	Bacillus thuringiensis HD-771 plasmid p03, complete sequence	38173-38201	8	0.724

1. spacer 1.1|2060808|29|NC_008508|CRISPRCasFinder matches to NZ_CP014852 (Bacillus thuringiensis strain HD12 plasmid pHD120161, complete sequence) position: , mismatch: 8, identity: 0.724

tcaacacgttagttgaaaaatagagcgaa	CRISPR spacer
acaacacgttagttgaagaatacggttct	Protospacer
 ****************.**** .*.

2. spacer 1.1|2060808|29|NC_008508|CRISPRCasFinder matches to NC_018487 (Bacillus thuringiensis HD-771 plasmid p03, complete sequence) position: , mismatch: 8, identity: 0.724

tcaacacgttagttgaaaaatagagcgaa	CRISPR spacer
acaacacgttagttgaagaatacggttct	Protospacer
 ****************.**** .*.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

536114 : 586922

Heterosigma_akashiwo_virus(25.0%)

protease,transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011669452.1\|536114_537209_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_040962987.1\|537921_538104_-	hypothetical protein	NA	NA	NA	NA
WP_011669453.1\|538410_539505_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011669454.1\|539916_540429_-	SRPBCC family protein	NA	NA	NA	NA
WP_002722981.1\|540561_541521_-	polyprenyl synthetase family protein	NA	NA	NA	NA
WP_002722990.1\|541589_542525_-	transglutaminase family protein	NA	NA	NA	NA
WP_011669455.1\|542903_543728_-	transketolase	NA	NA	NA	NA
WP_011669456.1\|543780_544167_-	DUF420 domain-containing protein	NA	NA	NA	NA
WP_011669457.1\|544701_546279_-	hypothetical protein	NA	NA	NA	NA
WP_011669458.1\|546268_549007_-	transglycosylase domain-containing protein	NA	NA	NA	NA
WP_011669459.1\|549052_549985_-	ChaN family lipoprotein	NA	NA	NA	NA
WP_011669460.1\|549995_550544_-	glutathione peroxidase	NA	NA	NA	NA
WP_011669461.1\|550847_551942_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011669462.1\|552481_552754_-	antitoxin	NA	NA	NA	NA
WP_026131168.1\|553356_553926_-	hypothetical protein	NA	NA	NA	NA
WP_011669465.1\|554218_555466_-	crotonyl-CoA carboxylase/reductase	NA	NA	NA	NA
WP_011669466.1\|556215_556974_+	hypothetical protein	NA	NA	NA	NA
WP_011669467.1\|557678_558554_-	J domain-containing protein	NA	NA	NA	NA
WP_011669468.1\|558698_560624_+	carbon starvation protein A	NA	NA	NA	NA
WP_011669469.1\|560620_561169_+	NUDIX hydrolase	NA	NA	NA	NA
WP_011669470.1\|561234_563004_+	OmpA family protein	NA	NA	NA	NA
WP_011669471.1\|563010_563763_+	NRDE family protein	NA	NA	NA	NA
WP_011669472.1\|563766_564147_+	PilZ domain-containing protein	NA	NA	NA	NA
WP_011669473.1\|564959_565769_+	hypothetical protein	NA	NA	NA	NA
WP_011669474.1\|566130_568161_+	DUF4178 domain-containing protein	NA	NA	NA	NA
WP_002723544.1\|568579_568774_+	hypothetical protein	NA	NA	NA	NA
WP_011669475.1\|568781_570278_+	polyamine aminopropyltransferase	A0A1C9C533	Heterosigma_akashiwo_virus	1.5e-10	29.1
WP_080507249.1\|570977_571271_-	DUF1877 family protein	NA	NA	NA	NA
WP_026054852.1\|571824_572199_+	hypothetical protein	NA	NA	NA	NA
WP_011669477.1\|572523_573618_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011669478.1\|574086_574557_-	EVE domain-containing protein	NA	NA	NA	NA
WP_011669479.1\|574553_576512_-\|protease	ATP-dependent zinc metalloprotease FtsH	C7U047	Ostreococcus_tauri_virus	4.2e-109	44.6
WP_011669480.1\|576667_577231_-\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_011669481.1\|577278_577917_-	50S ribosomal protein L25/general stress protein Ctc	NA	NA	NA	NA
WP_002723509.1\|577932_578871_-	ribose-phosphate pyrophosphokinase	A0A1V0SHF7	Hokovirus	1.2e-48	34.3
WP_002766579.1\|578867_579626_-	NTP transferase domain-containing protein	A0A1S5V090	Saudi_moumouvirus	2.4e-28	32.8
WP_002723513.1\|579730_580624_-	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	NA	NA	NA	NA
WP_011669482.1\|580978_581923_-	WYL domain-containing protein	NA	NA	NA	NA
WP_011669483.1\|582170_583568_+	hypothetical protein	NA	NA	NA	NA
WP_020780568.1\|583634_584057_+	hypothetical protein	NA	NA	NA	NA
WP_111303836.1\|584297_585560_-	hypothetical protein	NA	NA	NA	NA
WP_011669453.1\|585827_586922_-\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

969878 : 1042059

Tupanvirus(25.0%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011669695.1\|969878_972623_+\|tRNA	isoleucine--tRNA ligase	A0A2K9L9X8	Tupanvirus	4.7e-90	27.9
WP_011669696.1\|972979_973720_-	hypothetical protein	NA	NA	NA	NA
WP_002753620.1\|973716_974085_-	STAS domain-containing protein	NA	NA	NA	NA
WP_011669698.1\|974208_976050_+	hypothetical protein	NA	NA	NA	NA
WP_011669699.1\|976067_976787_+	amidohydrolase	NA	NA	NA	NA
WP_011669700.1\|977515_978478_-	hypothetical protein	NA	NA	NA	NA
WP_011669701.1\|978731_979988_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_011669702.1\|979999_981706_+	AarF/ABC1/UbiB kinase family protein	NA	NA	NA	NA
WP_002721192.1\|981702_982251_+	lipoprotein signal peptidase	NA	NA	NA	NA
WP_002753709.1\|982255_982783_+	cyclic nucleotide-binding domain-containing protein	NA	NA	NA	NA
WP_011669703.1\|982775_983843_+	AI-2E family transporter	NA	NA	NA	NA
WP_017859155.1\|984175_984328_-	hypothetical protein	NA	NA	NA	NA
WP_011669705.1\|985605_986529_-	EamA family transporter	NA	NA	NA	NA
WP_011669706.1\|987306_988401_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011669707.1\|988488_989355_-	bile acid:sodium symporter family protein	NA	NA	NA	NA
WP_011669708.1\|989597_990020_+	hypothetical protein	NA	NA	NA	NA
WP_026131187.1\|990082_990799_+	lysophospholipid acyltransferase family protein	NA	NA	NA	NA
WP_111303846.1\|991109_992426_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_002749789.1\|993106_993559_-	response regulator	NA	NA	NA	NA
WP_020780833.1\|993551_994949_-	sensor histidine kinase	W8CYF6	Bacillus_phage	9.8e-12	25.7
WP_011669711.1\|995241_996105_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_011669712.1\|996191_997226_+	CapA family protein	NA	NA	NA	NA
WP_111303847.1\|997631_998864_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_011669714.1\|999802_1000192_+	hypothetical protein	NA	NA	NA	NA
WP_011669715.1\|1000984_1001512_+	leucine-rich repeat domain-containing protein	NA	NA	NA	NA
WP_011669716.1\|1002168_1004301_+	TonB-dependent receptor	NA	NA	NA	NA
WP_011669717.1\|1004302_1005466_+	hypothetical protein	NA	NA	NA	NA
WP_011669718.1\|1005832_1006492_+	ankyrin repeat domain-containing protein	NA	NA	NA	NA
WP_011669719.1\|1006981_1008076_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011669720.1\|1009507_1010602_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011671649.1\|1012797_1013544_-	hypothetical protein	NA	NA	NA	NA
WP_020780011.1\|1014517_1015732_+	tetracycline resistance MFS efflux pump	A0A2H4UVM2	Bodo_saltans_virus	5.7e-08	21.1
WP_011669723.1\|1017931_1018789_+	pirin family protein	NA	NA	NA	NA
WP_011669724.1\|1018890_1019772_-	hypothetical protein	NA	NA	NA	NA
WP_111303833.1\|1020078_1021350_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_011669725.1\|1021677_1023498_+	translational GTPase TypA	NA	NA	NA	NA
WP_011669726.1\|1026114_1027050_-	hypothetical protein	NA	NA	NA	NA
WP_011669727.1\|1029202_1029847_-	hypothetical protein	NA	NA	NA	NA
WP_011669728.1\|1029843_1030437_-	molecular chaperone DnaJ	NA	NA	NA	NA
WP_002750674.1\|1030519_1031869_+\|tRNA	tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB	NA	NA	NA	NA
WP_011669729.1\|1031865_1033686_+	YjgP/YjgQ family permease	NA	NA	NA	NA
WP_011669730.1\|1033724_1034555_+	hypothetical protein	NA	NA	NA	NA
WP_002733069.1\|1034646_1035450_-	hypothetical protein	NA	NA	NA	NA
WP_002721507.1\|1035591_1036035_+	methylglyoxal synthase	NA	NA	NA	NA
WP_011669731.1\|1038971_1039349_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_002727231.1\|1039338_1039641_-	hypothetical protein	NA	NA	NA	NA
WP_011669733.1\|1040045_1040471_+	hypothetical protein	NA	NA	NA	NA
WP_080507253.1\|1041516_1042059_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	S5VSW1	Leptospira_phage	6.2e-39	50.5

DBSCAN-SWA_3

2259149 : 2320447

Bodo_saltans_virus(25.0%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011670454.1\|2259149_2259947_+\|tRNA	tRNA pseudouridine(38-40) synthase TruA	NA	NA	NA	NA
WP_011670455.1\|2259949_2260771_+	hypothetical protein	NA	NA	NA	NA
WP_002757492.1\|2260815_2262060_+	hypothetical protein	NA	NA	NA	NA
WP_011670457.1\|2262180_2262606_-	hypothetical protein	NA	NA	NA	NA
WP_011670458.1\|2263152_2264034_-	nitronate monooxygenase	NA	NA	NA	NA
WP_011670459.1\|2264275_2265370_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_002724562.1\|2265623_2266043_+	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_011670460.1\|2266123_2266525_-	DUF1801 domain-containing protein	NA	NA	NA	NA
WP_111303875.1\|2266967_2268239_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_011670462.1\|2268538_2269069_-	MepB family protein	A0A2H4UW84	Bodo_saltans_virus	6.8e-22	42.7
WP_011670463.1\|2269168_2270317_-	DUF445 family protein	NA	NA	NA	NA
WP_011670464.1\|2270316_2272662_-	hypothetical protein	NA	NA	NA	NA
WP_011670465.1\|2274263_2276096_+	alginate export family protein	NA	NA	NA	NA
WP_011670466.1\|2276123_2277128_+	sulfate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_011670467.1\|2279552_2280125_+	hypothetical protein	NA	NA	NA	NA
WP_011670468.1\|2280857_2281268_-	6-carboxytetrahydropterin synthase	NA	NA	NA	NA
WP_002724620.1\|2281422_2281650_+	DUF1858 domain-containing protein	NA	NA	NA	NA
WP_011670469.1\|2281815_2282574_+	hypothetical protein	NA	NA	NA	NA
WP_011670470.1\|2282631_2283441_-	hypothetical protein	NA	NA	NA	NA
WP_011670471.1\|2283701_2285207_-	rod shape-determining protein RodA	NA	NA	NA	NA
WP_011670472.1\|2285193_2287140_-	penicillin-binding protein 2	NA	NA	NA	NA
WP_002724635.1\|2287141_2287654_-	rod shape-determining protein MreD	NA	NA	NA	NA
WP_011670473.1\|2287650_2288760_-	rod shape-determining protein MreC	NA	NA	NA	NA
WP_002724608.1\|2288831_2289854_-	rod shape-determining protein	NA	NA	NA	NA
WP_011670474.1\|2290044_2291613_+	Ppx/GppA family phosphatase	NA	NA	NA	NA
WP_017859393.1\|2292101_2292356_+	hypothetical protein	NA	NA	NA	NA
WP_020780324.1\|2293771_2294479_+	DNA alkylation repair protein	NA	NA	NA	NA
WP_011670477.1\|2295307_2296474_-	hypothetical protein	NA	NA	NA	NA
WP_011670478.1\|2296792_2298214_-	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	2.7e-49	35.7
WP_011670479.1\|2298223_2300455_-	cyclic diguanylate phosphodiesterase	NA	NA	NA	NA
WP_041461105.1\|2300458_2303332_-	hypothetical protein	NA	NA	NA	NA
WP_011670481.1\|2303365_2303647_-	hypothetical protein	NA	NA	NA	NA
WP_011670482.1\|2303729_2304113_-	ATP synthase F1 subunit epsilon	NA	NA	NA	NA
WP_011670483.1\|2304117_2305521_-	F0F1 ATP synthase subunit beta	NA	NA	NA	NA
WP_002754308.1\|2305546_2306407_-	ATP synthase F1 subunit gamma	NA	NA	NA	NA
WP_011670484.1\|2306421_2307933_-	F0F1 ATP synthase subunit alpha	NA	NA	NA	NA
WP_002740769.1\|2307922_2308483_-	ATP synthase F1 subunit delta	NA	NA	NA	NA
WP_002754296.1\|2308487_2309009_-	F0F1 ATP synthase subunit B	NA	NA	NA	NA
WP_002632911.1\|2309012_2309315_-	ATP synthase F0 subunit C	NA	NA	NA	NA
WP_011670485.1\|2309356_2310466_-	F0F1 ATP synthase subunit A	NA	NA	NA	NA
WP_011670486.1\|2310570_2310900_-	hypothetical protein	NA	NA	NA	NA
WP_017859400.1\|2312202_2312520_-	hypothetical protein	NA	NA	NA	NA
WP_011670488.1\|2312716_2312923_-	hypothetical protein	NA	NA	NA	NA
WP_011670489.1\|2312953_2313262_-	AtpZ/AtpI family protein	NA	NA	NA	NA
WP_002731578.1\|2313290_2314292_-	signal peptidase I	NA	NA	NA	NA
WP_020780545.1\|2314379_2315183_+	aldolase/citrate lyase	NA	NA	NA	NA
WP_002754307.1\|2315185_2315737_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_017859401.1\|2317413_2317590_+	hypothetical protein	NA	NA	NA	NA
WP_011669401.1\|2317586_2318681_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_080504628.1\|2319034_2319370_-\|transposase	transposase	A0A0M5M147	Mycobacterium_phage	3.2e-09	39.8
WP_111303877.1\|2319546_2319765_-\|transposase	transposase	NA	NA	NA	NA
WP_011670491.1\|2319757_2320447_+\|transposase	transposase	Q9JMP3	Wolbachia_phage	1.4e-19	36.1

DBSCAN-SWA_4

2967205 : 2999573

Leptospira_phage(100.0%)

integrase,transposase

attL 2966713:2966740|attR 2977608:2977635

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2966713:2966740	attL	NA	NA	NA	NA
WP_011670849.1\|2967205_2968300_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011670850.1\|2969708_2969996_-	hypothetical protein	NA	NA	NA	NA
WP_002728978.1\|2971248_2972460_+	acetyl-CoA C-acetyltransferase	NA	NA	NA	NA
WP_162010757.1\|2973671_2974103_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	S5WIU1	Leptospira_phage	1.9e-62	83.2
WP_162010759.1\|2974106_2974328_+\|transposase	transposase	S5WIU1	Leptospira_phage	1.9e-31	87.7
WP_011670851.1\|2975091_2976054_+	porin OmpL1	NA	NA	NA	NA
WP_011670852.1\|2976381_2977332_-	cytochrome-c peroxidase	NA	NA	NA	NA
WP_002729082.1\|2977867_2979031_-	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
2977608:2977635	attR	NA	NA	NA	NA
WP_011670853.1\|2979308_2980481_-	CoA transferase	NA	NA	NA	NA
WP_017859288.1\|2980966_2981878_+	hypothetical protein	NA	NA	NA	NA
WP_011670854.1\|2981985_2982372_-	cation transporter	NA	NA	NA	NA
WP_011670855.1\|2982445_2983282_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_002728986.1\|2984022_2984349_+	hypothetical protein	NA	NA	NA	NA
WP_011670856.1\|2984405_2986739_+	TonB-dependent receptor	NA	NA	NA	NA
WP_002729106.1\|2986747_2987116_+	hypothetical protein	NA	NA	NA	NA
WP_011670857.1\|2987480_2988302_+	YdcF family protein	NA	NA	NA	NA
WP_002729012.1\|2988401_2988797_+	cytochrome c maturation protein CcmE	NA	NA	NA	NA
WP_011670858.1\|2988817_2991007_+	heme lyase CcmF/NrfE family subunit	NA	NA	NA	NA
WP_011670859.1\|2991003_2991600_+	cytochrome c-type biogenesis protein CcmH	NA	NA	NA	NA
WP_002752999.1\|2991599_2991998_+	zinc ribbon domain-containing protein	NA	NA	NA	NA
WP_011670860.1\|2991973_2992660_+	hypothetical protein	NA	NA	NA	NA
WP_111303888.1\|2993091_2994363_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_080507275.1\|2994895_2995438_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	S5VSW1	Leptospira_phage	5.6e-40	56.4
WP_002729103.1\|2996019_2997345_-	thiolase family protein	NA	NA	NA	NA
WP_011670862.1\|2997388_2998249_-	acyl-[acyl-carrier-protein] thioesterase	NA	NA	NA	NA
WP_111303888.1\|2998301_2999573_-\|transposase	IS4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_5

3114371 : 3187734

Cafeteria_roenbergensis_virus(11.11%)

transposase,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011670932.1\|3114371_3115466_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011670933.1\|3117272_3117974_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_011670934.1\|3118000_3118990_-	hypothetical protein	NA	NA	NA	NA
WP_011670935.1\|3119692_3120787_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011670936.1\|3121680_3122697_+	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	NA	NA	NA	NA
WP_011670937.1\|3123298_3124207_+	DMT family transporter	NA	NA	NA	NA
WP_011670938.1\|3125159_3125996_+	DUF4303 domain-containing protein	NA	NA	NA	NA
WP_017860114.1\|3126394_3126616_-	hypothetical protein	NA	NA	NA	NA
WP_020779796.1\|3127451_3128063_+	hypothetical protein	NA	NA	NA	NA
WP_011670940.1\|3132510_3132798_-	hypothetical protein	NA	NA	NA	NA
WP_011670941.1\|3132864_3133413_-	YqgE/AlgH family protein	NA	NA	NA	NA
WP_011670942.1\|3133436_3134405_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_011670943.1\|3134704_3135820_-	molecular chaperone DnaJ	E3T4P7	Cafeteria_roenbergensis_virus	3.3e-26	35.7
WP_011670944.1\|3136267_3138205_-	molecular chaperone DnaK	A0A2P1ELQ7	Moumouvirus	9.7e-143	47.2
WP_002723296.1\|3138239_3138893_-	nucleotide exchange factor GrpE	NA	NA	NA	NA
WP_002754054.1\|3138906_3139935_-	heat-inducible transcription repressor HrcA	NA	NA	NA	NA
WP_011670945.1\|3141097_3142906_+	PASTA domain-containing protein	NA	NA	NA	NA
WP_011670947.1\|3145143_3146235_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_111303892.1\|3147139_3148280_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	6.3e-41	36.0
WP_011670950.1\|3150722_3151106_+	hypothetical protein	NA	NA	NA	NA
WP_011670951.1\|3151258_3152047_+	glycerophosphodiester phosphodiesterase	A0A2H4PGQ5	Escherichia_phage	7.5e-17	25.9
WP_011670952.1\|3152228_3152660_-	SET domain-containing protein-lysine N-methyltransferase	A0A2H4UVV9	Bodo_saltans_virus	2.6e-08	30.6
WP_011670953.1\|3153289_3153778_+	RNA pyrophosphohydrolase	NA	NA	NA	NA
WP_011670955.1\|3154025_3154313_+	acylphosphatase	NA	NA	NA	NA
WP_002754046.1\|3154402_3155122_-	TrkA family potassium uptake protein	NA	NA	NA	NA
WP_011670956.1\|3155135_3156935_-\|portal	portal protein	NA	NA	NA	NA
WP_011670957.1\|3156934_3157828_-	hypothetical protein	NA	NA	NA	NA
WP_011670958.1\|3157886_3159188_-	adenosine deaminase	NA	NA	NA	NA
WP_011670959.1\|3159534_3160908_+	MATE family efflux transporter	NA	NA	NA	NA
WP_002754065.1\|3161269_3162292_+	GDP-mannose 4,6-dehydratase	M1HGM9	Acanthocystis_turfacea_Chlorella_virus	5.7e-118	60.6
WP_011670960.1\|3163016_3163796_+	acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase	NA	NA	NA	NA
WP_011670961.1\|3163792_3164764_+	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	2.5e-46	36.1
WP_011670962.1\|3164770_3165514_-	M15 family metallopeptidase	NA	NA	NA	NA
WP_011670964.1\|3167583_3169119_-	phosphomethylpyrimidine synthase ThiC	NA	NA	NA	NA
WP_011670965.1\|3169546_3169870_-	type II toxin-antitoxin system PemK/MazF family toxin	NA	NA	NA	NA
WP_011670966.1\|3169863_3170112_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_011670967.1\|3170792_3172967_-	ATP-dependent DNA helicase RecG	NA	NA	NA	NA
WP_011670968.1\|3172947_3173364_-	hypothetical protein	NA	NA	NA	NA
WP_011670969.1\|3173360_3174038_-	hypothetical protein	NA	NA	NA	NA
WP_002732926.1\|3174040_3175042_-	metallophosphoesterase	NA	NA	NA	NA
WP_011670970.1\|3175152_3175836_-	hypothetical protein	NA	NA	NA	NA
WP_011670971.1\|3175957_3176965_+	NAD(P)-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_011670972.1\|3176971_3179557_+	hypothetical protein	NA	NA	NA	NA
WP_011670973.1\|3179783_3181118_+	HlyC/CorC family transporter	NA	NA	NA	NA
WP_002753918.1\|3181137_3181680_+	phosphopantothenoylcysteine decarboxylase	Q9J5A8	Fowlpox_virus	5.1e-17	32.2
WP_011670974.1\|3181696_3182383_+	phosphopantothenoylcysteine decarboxylase	Q9HH70	Methanothermobacter_phage	5.2e-14	32.3
WP_011670975.1\|3182500_3184549_+	AAA family ATPase	NA	NA	NA	NA
WP_017859271.1\|3185084_3185258_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_002738799.1\|3185399_3185912_+	VOC family protein	NA	NA	NA	NA
WP_011669401.1\|3186639_3187734_-\|transposase	IS110 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_008509

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_008508

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection