CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NC_008042	Ruegeria sp. TM1040 plasmid unnamed, complete sequence	0 crisprs	NA	0	0
NC_008043	Ruegeria sp. TM1040 megaplasmid, complete sequence	0 crisprs	csa3,DEDDh,WYL	0	1
NC_008044	Ruegeria sp. TM1040, complete sequence	4 crisprs	csa3,cas3,WYL,DEDDh	1	8

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

569522 : 637490

Mycobacterium_phage(20.0%)

integrase,transposase

attL 616861:616875|attR 641494:641508

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_084789006.1\|569522_570452_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_085978750.1\|570524_571620_+\|transposase	IS3-like element ISSisp1 family transposase	NA	NA	NA	NA
WP_011537149.1\|572580_575973_-	DEAD/DEAH box helicase family protein	A0A097BY72	Enterococcus_phage	7.2e-16	25.3
WP_011537150.1\|575969_578069_-	DUF262 domain-containing protein	NA	NA	NA	NA
WP_011537151.1\|578093_579023_-	hypothetical protein	NA	NA	NA	NA
WP_011537152.1\|579024_580188_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_011537153.1\|580184_581759_-	SAM-dependent DNA methyltransferase	A0A1V0SLK8	Klosneuvirus	8.7e-25	29.1
WP_044026482.1\|582227_583835_-\|integrase	phage integrase N-terminal SAM-like domain-containing protein	NA	NA	NA	NA
WP_166485520.1\|583831_584038_-	AlpA family phage regulatory protein	NA	NA	NA	NA
WP_084789007.1\|584347_584524_-	AlpA family transcriptional regulator	Q7M299	Enterobacteria_phage	2.9e-06	46.3
WP_011537156.1\|586362_586938_-	BRO family protein	S5M7W3	Mycobacterium_phage	4.9e-10	32.1
WP_011537157.1\|587242_589153_-	hypothetical protein	NA	NA	NA	NA
WP_011537158.1\|589305_590034_-	M48 family metallopeptidase	NA	NA	NA	NA
WP_011537159.1\|590037_593316_-	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	1.1e-61	28.3
WP_166485502.1\|593427_594546_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_011537161.1\|594680_596180_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	6.5e-86	38.4
WP_011537156.1\|596706_597282_+	BRO family protein	S5M7W3	Mycobacterium_phage	4.9e-10	32.1
WP_011537162.1\|597613_598792_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_011537163.1\|599008_599191_-	DNA gyrase inhibitor YacG	NA	NA	NA	NA
WP_011537164.1\|599187_600210_-	ribonuclease E/G	NA	NA	NA	NA
WP_011537165.1\|600206_600788_-	septum formation protein Maf	NA	NA	NA	NA
WP_005620785.1\|600919_601138_-	translation initiation factor IF-1	NA	NA	NA	NA
WP_011537166.1\|601222_602101_-	carbon-nitrogen hydrolase family protein	NA	NA	NA	NA
WP_011537167.1\|602194_602782_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_011537168.1\|602781_603177_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_011537169.1\|603177_603633_-	low molecular weight phosphatase family protein	NA	NA	NA	NA
WP_011537170.1\|603636_604116_-	UPF0262 family protein	NA	NA	NA	NA
WP_011537171.1\|604395_605700_-	histidinol dehydrogenase	NA	NA	NA	NA
WP_011537173.1\|606234_607506_+	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_011537174.1\|607505_607982_+	DUF2948 family protein	NA	NA	NA	NA
WP_011537175.1\|608023_608818_-	3-oxoadipate enol-lactonase	NA	NA	NA	NA
WP_011537176.1\|608967_609945_-	threonine/serine dehydratase	NA	NA	NA	NA
WP_011537177.1\|609941_610790_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_011537178.1\|610812_611502_-	haloacid dehalogenase type II	NA	NA	NA	NA
WP_011537179.1\|611668_612097_+	peptidylprolyl isomerase	NA	NA	NA	NA
WP_011537180.1\|612349_613423_+	extracellular solute-binding protein	NA	NA	NA	NA
WP_044026484.1\|613573_614725_+	lytic murein transglycosylase	NA	NA	NA	NA
WP_011537182.1\|614750_615059_-	hypothetical protein	NA	NA	NA	NA
WP_011537183.1\|615048_616101_-	hypothetical protein	NA	NA	NA	NA
WP_011537184.1\|616097_616508_-	hypothetical protein	NA	NA	NA	NA
WP_011537185.1\|616504_617992_-	FAD-binding oxidoreductase	A0A2K9KZR0	Tupanvirus	1.4e-45	26.4
616861:616875	attL	NA	NA	NA	NA
WP_011537186.1\|618301_621514_+	4Fe-4S dicluster domain-containing protein	NA	NA	NA	NA
WP_011537187.1\|628193_629282_-	hypothetical protein	NA	NA	NA	NA
WP_166485503.1\|629291_630899_-	AAA family ATPase	NA	NA	NA	NA
WP_011537189.1\|631197_632346_-	hypothetical protein	NA	NA	NA	NA
WP_011537190.1\|632526_632745_-	hypothetical protein	NA	NA	NA	NA
WP_009176818.1\|632863_633052_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_166485504.1\|633224_633923_-	hypothetical protein	NA	NA	NA	NA
WP_044026487.1\|634103_635282_-\|integrase	tyrosine-type recombinase/integrase	A0A0S2SYQ7	Pseudomonas_phage	2.1e-15	33.9
WP_011537194.1\|636896_637490_+\|integrase	tyrosine-type recombinase/integrase	B0VK72	Azospirillum_phage	6.6e-18	40.8
641494:641508	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_008044

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CRISPR-Cas detection and classification

Crispr_ID: NC_008044_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008044_1

2396234-2396396

Orphan

Consensus_repeat	Method
CCAATGGCGACGTCTACGAGGGCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_008044_1

>merge|NC_008044|1|2396234-2396396|CRISPRCasFinder
CAAATGGATCAGTCTACGAGGGTGAGTTTTCCAAGGGGAAACCCGAAGGTCTGGGCAAGATCACCTTTGCCGATGGCGGCACCTATGAAGGCGAGTGGCAAGACGGTGTGATCAATGGCCAAGGCATTGCGATCTATGCCAATGGGGTGCGCTACGAGGGGTC

>NC_008044|1|1|2396234-2396396|CRISPRCasFinder
CAAATGGATCAGTCTACGAGGGTG	AGTTTTCCAAGGGGAAACCCGAAGGTCTGGGCAAGATCACCTTTG
CCGATGGCGGCACCTATGAAGGCG	AGTGGCAAGACGGTGTGATCAATGGCCAAGGCATTGCGATCTATG
CCAATGGGGTGCGCTACGAGGGGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008044.1\|WP_011539596.1\|2390225_2391551_-\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|183594
NC_008044.1\|WP_011539595.1\|2388962_2390147_+\|DUF2254-domain-containing-protein	unknown	unknown	gnl\|CDD\|378351
NC_008044.1\|WP_011539608.1\|2407322_2407670_+\|cytochrome-o-ubiquinol-oxidase-subunit-IV	unknown	unknown	gnl\|CDD\|225667
NC_008044.1\|WP_011539592.1\|2385285_2387814_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225669
NC_008044.1\|WP_044027248.1\|2394153_2395812_-\|NAD+-synthase	unknown	unknown	gnl\|CDD\|237577
NC_008044.1\|WP_011539591.1\|2384584_2385289_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226647
NC_008044.1\|WP_011539594.1\|2388396_2388966_+\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|119400
NC_008044.1\|WP_011539590.1\|2383854_2384532_-\|arylesterase	unknown	unknown	gnl\|CDD\|238860
NC_008044.1\|WP_011539601.1\|2397494_2398535_+\|hypothetical-protein	unknown	unknown	unknown
NC_008044.1\|WP_011539597.1\|2391779_2392718_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293806
NC_008044.1\|WP_011539606.1\|2404641_2406678_+\|cytochrome-o-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|131890
NC_008044.1\|WP_011539602.1\|2398531_2400055_-\|cryptochrome/photolyase-family-protein	unknown	unknown	gnl\|CDD\|225588
NC_008044.1\|WP_011539609.1\|2407666_2408398_+\|Surfeit-locus-1	unknown	unknown	gnl\|CDD\|225883
NC_008044.1\|WP_011539610.1\|2408454_2408850_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319900
NC_008044.1\|WP_011539593.1\|2387828_2388293_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NC_008044.1\|WP_011539605.1\|2403546_2404638_+\|ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|213620
NC_008044.1\|WP_011539598.1\|2392714_2394016_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NC_008044.1\|WP_011539604.1\|2402079_2403336_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NC_008044.1\|WP_011539603.1\|2400414_2401998_+\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|234864
NC_008044.1\|WP_011539607.1\|2406681_2407326_+\|cytochrome-o-ubiquinol-oxidase-subunit-III	unknown	unknown	gnl\|CDD\|131889

Protein	Function_ID	Function_description	E-value
NC_008044.1\|WP_011539596.1\|2390225_2391551_-\|glutamate--tRNA-ligase	gnl\|CDD\|183594	PRK12558, PRK12558, glutamyl-tRNA synthetase; Provisional.	0
NC_008044.1\|WP_011539595.1\|2388962_2390147_+\|DUF2254-domain-containing-protein	gnl\|CDD\|378351	pfam10011, DUF2254, Predicted membrane protein (DUF2254). Members of this family of bacterial proteins comprises various hypothetical and putative membrane proteins. Their exact function, has not, as yet, been defined.	1.3561e-109
NC_008044.1\|WP_011539608.1\|2407322_2407670_+\|cytochrome-o-ubiquinol-oxidase-subunit-IV	gnl\|CDD\|225667	COG3125, CyoD, Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion].	5.11992e-31
NC_008044.1\|WP_011539592.1\|2385285_2387814_+\|ABC-transporter-permease	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	0
NC_008044.1\|WP_044027248.1\|2394153_2395812_-\|NAD+-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NC_008044.1\|WP_011539591.1\|2384584_2385289_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226647	COG4181, COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism].	2.01285e-105
NC_008044.1\|WP_011539594.1\|2388396_2388966_+\|gamma-glutamylcyclotransferase	gnl\|CDD\|119400	cd06661, GGCT_like, GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).	2.3873e-08
NC_008044.1\|WP_011539590.1\|2383854_2384532_-\|arylesterase	gnl\|CDD\|238860	cd01822, Lysophospholipase_L1_like, Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity.	5.76155e-78
NC_008044.1\|WP_011539593.1\|2387828_2388293_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	8.55107e-42
NC_008044.1\|WP_011539597.1\|2391779_2392718_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293806	cd07720, OPHC2-like_MBL-fold, Pseudomonas pseudoalcaligenes organophosphorus hydrolase C2, and related proteins; MBL-fold metallo hydrolase domain. Pseudomonas pseudoalcaligenes OPHC2 is a thermostable organophosphorus hydrolase which a broad substrate activity spectrum: it hydrolyzes various phosphotriesters, esters, and a lactone. This subgroup also includes Pseudomonas oleovorans PoOPH which exhibits high lactonase and esterase activities, and latent PTE activity. However, double mutations His250Ile/Ile263Trp switch PoOPH into an efficient and thermostable PTE. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.42137e-82
NC_008044.1\|WP_011539606.1\|2404641_2406678_+\|cytochrome-o-ubiquinol-oxidase-subunit-I	gnl\|CDD\|131890	TIGR02843, Cytochrome_bo3_ubiquinol_oxidase_subunit_1, cytochrome o ubiquinol oxidase, subunit I. Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain which reacts with oxygen, reducing it to water with the concomitant transport of 4 protons across the membrane. Also known as the cytochrome bo complex, cytochrome o ubiquinol oxidase contains four subunits, two heme b cofactors and a copper atom which is believed to be the oxygen active site. This complex is structurally related to the cytochrome caa3 oxidases which utilize cytochrome c as the reductant and contain heme a cofactors, as well as the intermediate form aa3 oxidases which also react directly with quinones as the reductant. [Energy metabolism, Electron transport].	0
NC_008044.1\|WP_011539602.1\|2398531_2400055_-\|cryptochrome/photolyase-family-protein	gnl\|CDD\|225588	COG3046, COG3046, Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only].	0
NC_008044.1\|WP_011539609.1\|2407666_2408398_+\|Surfeit-locus-1	gnl\|CDD\|225883	COG3346, COG3346, Uncharacterized conserved protein [Function unknown].	1.37951e-50
NC_008044.1\|WP_011539610.1\|2408454_2408850_-\|VOC-family-protein	gnl\|CDD\|319900	cd07233, GlxI_Zn, Glyoxalase I that uses Zn(++) as cofactor. This family includes eukaryotic glyoxalase I that prefers the divalent cation zinc as cofactor. Glyoxalase I (also known as lactoylglutathione lyase; EC 4.4.1.5) is part of the glyoxalase system, a two-step system for detoxifying methylglyoxal, a side product of glycolysis. This system is responsible for the conversion of reactive, acyclic alpha-oxoaldehydes into the corresponding alpha-hydroxyacids and involves 2 enzymes, glyoxalase I and II. Glyoxalase I catalyses an intramolecular redox reaction of the hemithioacetal (formed from methylglyoxal and glutathione) to form the thioester, S-D-lactoylglutathione. This reaction involves the transfer of two hydrogen atoms from C1 to C2 of the methylglyoxal, and proceeds via an ene-diol intermediate. Glyoxalase I has a requirement for bound metal ions for catalysis. Eukaryotic glyoxalase I prefers the divalent cation zinc as cofactor, whereas Escherichia coil and other prokaryotic glyoxalase I uses nickel. However, eukaryotic Trypanosomatid parasites also use nickel as a cofactor, which could possibly be explained by acquiring their GLOI gene by horizontal gene transfer. Human glyoxalase I is a two-domain enzyme and it has the structure of a domain-swapped dimer with two active sites located at the dimer interface. In yeast, in various plants, insects and Plasmodia, glyoxalase I is four-domain, possibly the result of a further gene duplication and an additional gene fusing event.	6.8109e-20
NC_008044.1\|WP_011539605.1\|2403546_2404638_+\|ubiquinol-oxidase-subunit-II	gnl\|CDD\|213620	TIGR01433, precursor_Cytochrome_o_subunit_2_Oxidase, cytochrome o ubiquinol oxidase subunit II. This enzyme catalyzes the oxidation of ubiquinol with the concomitant reduction of molecular oxygen to water. This acts as the terminal electron acceptor in the respiratory chain. Subunit II is responsible for binding and oxidation of the ubiquinone substrate. This sequence is closely related to QoxA, which oxidizes quinol in gram positive bacteria but which is in complex with subunits which utilize cytochromes a in the reduction of molecular oxygen. Slightly more distantly related is subunit II of cytochrome c oxidase which uses cyt. c as the oxidant. [Energy metabolism, Electron transport].	3.64826e-115
NC_008044.1\|WP_011539598.1\|2392714_2394016_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	2.17949e-70
NC_008044.1\|WP_011539604.1\|2402079_2403336_-\|MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.57356e-79
NC_008044.1\|WP_011539603.1\|2400414_2401998_+\|2-isopropylmalate-synthase	gnl\|CDD\|234864	PRK00915, PRK00915, 2-isopropylmalate synthase; Validated.	0
NC_008044.1\|WP_011539607.1\|2406681_2407326_+\|cytochrome-o-ubiquinol-oxidase-subunit-III	gnl\|CDD\|131889	TIGR02842, Cytochrome_bo3_ubiquinol_oxidase_subunit_3, cytochrome o ubiquinol oxidase, subunit III. Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain which reacts with oxygen, reducing it to water with the concomitant transport of 4 protons across the membrane. Also known as the cytochrome bo complex, cytochrome o ubiquinol oxidase contains four subunits, two heme b cofactors and a copper atom which is believed to be the oxygen active site. This complex is structurally related to the cytochrome caa3 oxidases which utilize cytochrome c as the reductant and contain heme a cofactors, as well as the intermediate form aa3 oxidases which also react directly with quinones as the reductant. [Energy metabolism, Electron transport].	2.64602e-84

>NC_008044.1|WP_044027248.1|2394153_2395812_-|NAD+-synthase
MADSFRITLAQLNPTVGDLAGNAAKALSAWQEGRAADADLVALPEMFITGYNTQDLVMKPAFHQAAIAEVEALAKATAEGPALAIGSPWVEDGKLYNAYLILKGGKIASKCLKHHLPNETVFDEVRIFDAGPLGGPYSVGNTRIGSPICEDGWHEDVAETLEETGAEFLLIPNGSPYYRGKMETRINHMVARAVETGLPVIYLNMVGGQDDQVFDGGSFALNPHGALAVQMPVFDECIAQLDLERTADGWRIKEGEKAHLPDAWEQDYRTMVLSLRDYMGKTGFKKALLGLSGGVDSAIVAAIAVDALGAENVRCVMLPSEYTSKESLEDAEAVAKALGVHYDYVPISEGREAITNTLAPLFAGRDADLTEENIQSRLRGLLLMAMSNKFGEMLLTTGNKSEVAVGYATIYGDMNGGYNPIKDLYKTRVFETCRWRNANHRDWMMGPEGEVIRPNVIDKPPSAELREDQKDSDSLPDYPELDAILDILVDQEGSIADCVAAGFDRDVAKRVEHLLYISEYKRFQSAPGARLTKRAFWLDRRYPIVNRWRDPS
>NC_008044.1|WP_011539598.1|2392714_2394016_-|FAD-binding-oxidoreductase
MPGPQLPHFNSDRVLPKAVDVVIIGGGIVGASTALELAERGHSVLLCEKGQIAGEQSSRNWGWVRMSQRDPREMELMTHSQRIWEGLDMRTGYATGYTKCGIMFTAHTRKREAELSAWSEHLKAIGGEGHMLRGESLEQLTPGYGHRIRAGFYTPQDGCAEPQMATHAIASAARDKGAVVITGCAVRRLDVEAGRIRGVITEKGRVNATAVVVAGGAWSRLFLRNEGLFLPQLKVLNSVMRLSPVKGVPETALWAAGFGLRKRMDGGYTVASGGENTFDIVPDTFRIGHRFIPAFLRDVTALRFRVSDRWRIESAEARPWSGQDRSPFEETRVLDPQPSQKALRRGLAAVRDAFPALEKADVTQSWGGLIDVTPDEIPVISEVISRPGLFVSTGYSGHGFGLGPGAGRLTADLVTGDAPIVDPRPFRLSRFGA
>NC_008044.1|WP_011539597.1|2391779_2392718_+|MBL-fold-metallo-hydrolase
MTLKLSRRAALAGVAAAPIAAAVAAPARAAGHEAAKAPLHARAFKVGDYTVHSLLAGSTGRDGVKDIFGGGASDEAFSEVAAENFISDTSAQFYFTPTLVDTGSEKILFDTGLNAGGITKALADAGVTPEEVDVVVLTHMHGDHIGGMTDDSGAATFANARYVTAAAEYDHWTAMPEGNGGADRVRAKVAPQAEKMSFIDDGGAVASGVTGMAAFGHTPGHMVYMIESAGQQLLLTADLANHYVFPFAHPEWQTSFDTDKDAASATRRRVLEMLADSRTPMIGYHMPFPAAGYVERRGEGFRFVPVSYQMMG
>NC_008044.1|WP_011539596.1|2390225_2391551_-|glutamate--tRNA-ligase
MTTTRFAPSPTGYIHVGNLRTALMNYLIARKAGGTFILRIDDTDPERSKEEYVDAIKQDLEWLGITWDKVERQSERLDRYAEAADKLREIGRFYEAFETPTELDLKRKKQLNMGKPPVYDRAALALSDAEKESLRAERGNGVWRFKLDQERIEWTDGILGDISIDAASVSDPVLIRGDGQVLYTIASVVDDTDMGVTHVVRGSDHVTNTATQIQIMAALGHGHPEFAHHSLLTGPQGEALSKRLGTLALRDLREAGVKPMALLSLMARLGSSDPVELRTDMAELVDGFDINRFGSAPTKFDAEDLYPLTARYLQTLPVATVKSELDAIGVPADTQEAFWAVAKENITTLKDLEGWWILCRDGAEPLIADEDKEFIAEAMTLLPEGPYDSESWGKWTAAVKEKTGRKGKGLFMPLRKAVTGMERGPDMSALLALMQTVRARG
>NC_008044.1|WP_011539595.1|2388962_2390147_+|DUF2254-domain-containing-protein
MISRSLLLLRRITRQLWFRVVAISLFSLLALAIAPLLAPILPPAWEDRFGREAVLPVLTILASGMLAVTTFSLNVMVSAYRTASSMATPRVYRLLLEDTVTQSVLATFTGGFVYSLSAVILFRAGIYPPGSAFVVFVMTALVVMLIVLAILRWIDHLSDLGSMDHTLRLIESRSCSSLRARKETPCLGGCCLKTEPPSSASPIPASQSGFVRFVDMAALNRRAKEAGVTLYLTRLPGEFVLRGRPVAMAEGADEAFCKEASGLIDVGDVRSFEQDPTFGLTLLAETAQRALSPGVNDPGTAYEVMGRLTRLLWENLPEDSEATKSDADFPHIHLPPVTASALLKASFPPIALYAGDAPEVMDWMQTSLKALEHHPNAAMTRAAQEMRQDYFENS
>NC_008044.1|WP_011539594.1|2388396_2388966_+|gamma-glutamylcyclotransferase
MTPHFFGFGSLVNTATHVYGNTRPARLEGWRRTWVRTPDRSMAFLSVTPAPGHVIEGLLAAVPNGDWAALDERETGYVRVDVTPQVAHDMAPAPQISLYQVPEESHDRNARDHKILLSYLDVVLRGYREVFGDTGAEAFMATTDGWDTPILNDRATPYYPRHQVMTPDEHALHDALIAEAGAQVLAGGE
>NC_008044.1|WP_011539593.1|2387828_2388293_-|Rrf2-family-transcriptional-regulator
MRITKRTNIAVRLLMYCALNEGRLVTKSEIAARCNISENHLAQVVNQLSQLGFLKTQRGRNGGLALGRAAADICIGDVFRQVEGGLPMVECFADVDNTCPLVEACRLRDALTRAGEAFYGALDGISLESLTCDNIDLQRILSPLSCPSPAKTPA
>NC_008044.1|WP_011539592.1|2385285_2387814_+|ABC-transporter-permease
MSQKSSFRLAWRFALRELRGGLRGFRLFLACLALGVGVIAAIGSIRASIEAGLSREGASLLGGDAELTFTYRFANPDEIAWMDEIARDRSEVVEFRSMAVVGDERALTQVKSVDAAYPLRGDFRLMSGQPLHEALAAADGRPGAVMERVLADRLGLSEGSVFRLGTQEFRLSGLLEWEPDAAGSGFSIGPRTLVRTEALAQSGLLAPGTLYSTKYRLTLPPDADLAALEQDARARFEESGMRWRDARNGAPGIARFVERLGAFLVLVGLSGLAVGGVGVSTAVRAYLATKTETIATLRTLGSERRVIFLTYFLQIGVLSLCGITLGLILGGVGPLLLGPLIAAQLPFPAVFSIYPAALAESALYGVLTALLFTLWPLARTERIRAAALYRDAVSGGLQWPAPRYILATLATLGLLIAAAALFSGAPELALWTAGGLIGALVVLLIAGAAIGGLARMGNRMARGRPALRWALASIASARDGAMPAVLALGLGLTVLAAIGQIDGNMRRAIAGNLPDVAPSYFFVDIQRDQMPAFLERVEGDPQVSKVDNAPMLRGVITRINDRPAKEVAGDHWVIRGDRGVTYAAAKPASTNVTAGAWWPEDYTGPPQISFAAEEAEEMGLALGDTLTVNVLGRDITGTITSFREVDFSNAGMGFVLTMNEAALRGAPHSYIASVYAEEDAEAAILRDVAREMPNITAIRVRDAINRVSEILGQLATATAYGAAATLFTGFLVLLGTAAAAEPARRYEAALLKTLGAPRGQILRSFALRSAILGAAAGGVALLAGILGAWSVSHFVLETDYVVIWPNAVGVIGGGILVTLFAGLAYALRPLAARPARVLRARD
>NC_008044.1|WP_011539591.1|2384584_2385289_+|ABC-transporter-ATP-binding-protein
MSTDARPILTLQDVHLSLNGNTGPVRILEEISLEVQSGETLALVGPSGSGKSSLLMVMGGLEQATGGQVRAMGEDLTRLDEDALARFRRAHMGVVFQSFHLIPTMTALENVATPLELAGARDAFDRARDELEAVGLGHRCDHMPAQMSGGEQQRVALARAVVTRPEILLADEPTGNLDQANGAQVMDLLFDLRDRHGSTLVMVTHAPELAERCDRTIRLRDGRILTDAQREAAE
>NC_008044.1|WP_011539590.1|2383854_2384532_-|arylesterase
MRKFLKQIVVSLVSIPLLLGVAQAEPVRITAFGDSLVQGYGLPQGEGLVAQLRDWFAVEGFDVALTNAGVSGDTTAGGAARIDWTLAETPDAMIVLLGGNDLLRGLPPEDTRANLSRIIEAARGAGAEVLLIGMQAPGNYGADYKAAFDSIYPDLTATHDLVLHPFAFAGMAAEAGEDPAQMGAYMQADGIHPNARGVALNIKAMEPALHALMARLSQPEDSANN
>NC_008044.1|WP_011539601.1|2397494_2398535_+|hypothetical-protein
MATLLYLVHGAAVQQQQQLSYSVLSALKHGVDGVDLVLICDAANRRPDLPLRHVVISPEQIAQWTDGGRRPARAQLHALDLALRETGGPVCWASTDSAFTAAPARLLERITPETPLFFDRDGWLTSRPEWSPIIDACKDSALSEQIQPSTEVFDTGILGLSPSDLDFINQSLSPSFWPRIPNIFDNFEQIHLCALLAQNAQELRFSHDLVQRYQGYMRHVYQGRLEAMFPPGGAVNTALAAQLPAITEPPKPLHLRLKAKAYALRRGLGHGTEFGYLAYLCAFAAPTPEGRNVWANIALDMMERSARAPQKLVKDLSKLAPEALPDAELSPQTEERWRRYWMNAGL
>NC_008044.1|WP_011539602.1|2398531_2400055_-|cryptochrome/photolyase-family-protein
MTRLVLVLGDQLSEGLSALKAADPAHDVVVMAEVMDEGTYVPHHPKKIALVLAAMRKFAQRLEGQGWRVAYRRLDEDGAESIVGELLRRAEEFGASEVLATTPGEWRLIHALKYAPLKVHFHADDRFLATREDFTEWAEGKKQLRMEYFYRLMRKKTGLLMEGDTPVGGKWNYDSENRKAPPKIIDHKGPPRFEPDAEVEEVLDLVEARFGTHFGDLRPFWFATTREEAQEALAHFITHALPQFGDYQDAMMTDERWLYHSILSPYLNIGLLTPLEICEAAEVAHQDGHAPLNAVEGFIRQILGWREYVRGIYFLEGEDYPTRNALEQTRALPALYWGAETDMHCLSQAVEQTGQEAYAHHIQRLMVTGNFALLAGVDPAQVHEWYLAVYADAFEWVEAPNTVGMSQFADGGIIASKPYVSSGAYIDRMSNYCGSCAYKVKQKTGEGACPFNLLYWDFLNRHRARFEGNPRMGNMYRTWDRMDEEKRDVILQEASAFLAKLDAGERV
>NC_008044.1|WP_011539603.1|2400414_2401998_+|2-isopropylmalate-synthase
MTSKTDTVNQQDRVLIFDTTLRDGEQSPGATMTHDEKLEIAELLDDMGVDIIEAGFPIASEGDFKAVSEIAERSKNSVICGLARANFKDIDRCAEAVRKAAKPRIHTFIGTSPLHRAIPNLTMDEMAERIHDTVTHARNLVDNVQWSPMDATRTEWDYLCRVIEIAIKAGATTINIPDTVGYTAPRESADLIRRLIETVPGADEIIFATHCHNDLGMATANSLAAVEAGARQIECTINGLGERAGNTALEEVVMAMRVRNDIMPFQTGIDTKKIMHISRRVATVSGFNVQFNKAIVGKNAFAHESGIHQDGMLKNKETFEIMRPEDVGLAGTSLPLGKHSGRAALRDKLSSLGFEIGDNQLKDVFVRFKELADRKKEVFDDDIIALMRTSGDEDDHLKLVSMKVVCGTGGPAESTVEMEVDGKDVTETAEGDGPVDATFKAIRKIHPNAAHLQLYQVHAVTEGTDAQATVSVRLEEDGVIATGDSANTDTVVASAMAYIDALNRLIVRRDKMGEGADSREISYKDVD
>NC_008044.1|WP_011539604.1|2402079_2403336_-|MFS-transporter
MTTTEANAQHSDVTFDDVIITVVMARVTDFFGFFVYAIASALVFPAVFFPHLDPMMGTLWSFALFSLAFLARPIASLLGRRLQLVIGRAGKVTVALMILGVSTVAIGLLPGYEAWGIGAPIALAALRFMQGLGLGGAWDGITLQLKAAAPKGQSGLYSMVPQIGGPVGFCVAAALFYVLTGFLSEEEFLTYGWRFAFFAVMAVNVVSLFARLRLLSTNFAGDDEVVLRSAPLGELMSQEWRTIVLSALLPLASYALFHMVTVFPLSYSLLFTESNLSSILLLQLAGGTLAIVTVILSGVLADKFGRPVVLWISSALILLLCLSIGTLERAPAIYIIFGFVVLGLAYGQSSAIVPDRFKPQYRYSGAAMATNLSWILGAAFAPLCGLVLAWTFGLWAAALYLLSGVIVTAVALVLLQRQ
>NC_008044.1|WP_011539605.1|2403546_2404638_+|ubiquinol-oxidase-subunit-II
MRYLRFLCCALAFLTLSGCNLVLLSPSGDIAAQQGDLIVYSTVLMLIVIIPVMALTVFFAFKYRAENKDARYEPDWDHSVSLEIVVWFVPLAIIICLAGLTWVATHRLEPYDDLRRVSETKPIDPNVEPMEVQVVALDWKWLFIYPEYGVATVNEAAAIVDRPVEWKLTSSTVMNAFYIPEMAGMIYAMAGMETELNAVINEPGTFEGFSANYSGNGFSHMRFDFIAEDEAGFEAWIEEVRASGMTLDQDSYAVLEQPSVAHEVEYFGAVEDGLWDKILNMCAGPNALCLNDMMMVDALGGGGLAGLYNRELYRGICSADDPEALLAMLRPDIQEEQQREDILQAMTLTSGDLLPNSNTTEAN
>NC_008044.1|WP_011539606.1|2404641_2406678_+|cytochrome-o-ubiquinol-oxidase-subunit-I
MATIPAATAAAQSSDALNQTHWFWGKLGWDIFPFYDPIIFGTFIGTCILAAGVVGIVLYYRLLPYLWNEWFTTVDHKKIGIMYMILAVVMLVRGFADAVLMRLHQALASAGYVGFLPAYHYDQVFTAHGVIMIFFVAMPFITGFMNYVMPLQIGARDVAFPFLNNFSFWLTVSGAVLIMISLFVGEFAATGWLAYAPLSGLKFSPGVGMDYYLWSLNIAGIGTTLSGINLVVTLVKMRAPGMTWMKLPIFSWTTLCTNILIVVTFPVLTATLALLTADRYLGTHFFTNEMGGNPMMYVNLIWIWGHPEVYILILPIFGIFSEIVATFCGKRLFGYASMVYATCVIMVLSYIVWLHHFFTMGAGADVNSFFGITTMIISIPTGAKLFNWLFTMYKGRIRFELPMMWTIAFMLTFVVGGMTGVLLAVPPADYVLHNSLFLIAHFHNVIIGGVVFGIFAGITYWWPKAFGFHLDPFWGKVSFWGWVGGFWVAFMPLYLLGLMGVTRRLSQFEDTIYAGYFFTALIGALMIAVGLLAFLVQIFVSIRNREKLAVGNDPWGGRTLEWSTTSPPPYYNFAFTPRVYERDAWHHMKTHDAKAPTSGFVPIHMPHYTASGIILAGLMTVMGFALVWHIWWLSALMFLASLAYGIAHTFNYNRDYYVPAEEVSEIETGQRTVATPAE
>NC_008044.1|WP_011539607.1|2406681_2407326_+|cytochrome-o-ubiquinol-oxidase-subunit-III
MSHSAATPAPEALEFYVTEDPHAGHGDHHHDTGTMLGFWIYLMSDCLIFGILFAVHAVVGTSYAAGPSPADLFEIDKILLATFFLLFSSITYGFAVINMQQRKQRAMMLWLGVTLVFGLGFLVMEILEFQHLWHLGAGPGASAFLSSFWVLVGTHGLHVTAGAIWLVVLLVQVQMHGLTEANTRRILCLSMFWHFLDLIWIGVFSFVYLTGVLL
>NC_008044.1|WP_011539608.1|2407322_2407670_+|cytochrome-o-ubiquinol-oxidase-subunit-IV
MSAHSHGSYKSYAIGFVLSVILTVIPFWLVLGEVDIGVNTAIAVIFGLGAVQIIVHMHYFLHVTYGAEDGWQVMSLVFTGILLIIVLAGSIWVMAHLHENMMPAHEQIERVRNLP
>NC_008044.1|WP_011539609.1|2407666_2408398_+|Surfeit-locus-1
MSTGTSTEGGGRRRPFWVDAVILALAFGVFVTMVRLGNWQMQRLSWKLDLIEQVETRAFGPPVAAPIKGAAPEYQRVTLQGVFRHDLSLRIKAVTEIGPGSWVMTPIEGAEQTVWVNRGFVPPQMRLDEINRPEGLQEITGLIRSDQPGGTLLEQNLPDRDRWVSADLALMSADRGIEAAGYYIDAAHQGAAADWPRGGMTQLDFRNTHLSYALTWYAMAVLFFGAMAYVIWDRLRAPKERTS
>NC_008044.1|WP_011539610.1|2408454_2408850_-|VOC-family-protein
MTKLAHSMIRVLDETASVAFYKAAFDMEIADRLDFDDFTLIYLTAPEGSFELELTVNKSQTEAYDLGNGYGHLAVVVEDLEAARAKVETAGGAPRDIVDFRPAGERVARFFFVADPDGYQIEVIEAGGRFK

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Crispr_ID: NC_008044_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008044_2

2396648-2396741

Orphan

Consensus_repeat	Method
CCAATGGCGACGTCTACGAGGGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008044_2

>merge|NC_008044|2|2396648-2396741|CRISPRCasFinder
CCAATGGCGACGTCTACGAGGGCCCGCTGGTCAACGGTCGTCGTCAGGGCGAGGGCGTGCTGCGCTATGCCAATGGCGATGTCTACGAGGGCCA

>NC_008044|2|2|2396648-2396741|CRISPRCasFinder
CCAATGGCGACGTCTACGAGGGCC	CGCTGGTCAACGGTCGTCGTCAGGGCGAGGGCGTGCTGCGCTATG
CCAATGGCGATGTCTACGAGGGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008044.1\|WP_011539596.1\|2390225_2391551_-\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|183594
NC_008044.1\|WP_011539595.1\|2388962_2390147_+\|DUF2254-domain-containing-protein	unknown	unknown	gnl\|CDD\|378351
NC_008044.1\|WP_011539608.1\|2407322_2407670_+\|cytochrome-o-ubiquinol-oxidase-subunit-IV	unknown	unknown	gnl\|CDD\|225667
NC_008044.1\|WP_011539592.1\|2385285_2387814_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225669
NC_008044.1\|WP_044027248.1\|2394153_2395812_-\|NAD+-synthase	unknown	unknown	gnl\|CDD\|237577
NC_008044.1\|WP_011539591.1\|2384584_2385289_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226647
NC_008044.1\|WP_011539594.1\|2388396_2388966_+\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|119400
NC_008044.1\|WP_011539590.1\|2383854_2384532_-\|arylesterase	unknown	unknown	gnl\|CDD\|238860
NC_008044.1\|WP_011539601.1\|2397494_2398535_+\|hypothetical-protein	unknown	unknown	unknown
NC_008044.1\|WP_011539597.1\|2391779_2392718_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293806
NC_008044.1\|WP_011539606.1\|2404641_2406678_+\|cytochrome-o-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|131890
NC_008044.1\|WP_011539602.1\|2398531_2400055_-\|cryptochrome/photolyase-family-protein	unknown	unknown	gnl\|CDD\|225588
NC_008044.1\|WP_011539609.1\|2407666_2408398_+\|Surfeit-locus-1	unknown	unknown	gnl\|CDD\|225883
NC_008044.1\|WP_011539610.1\|2408454_2408850_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319900
NC_008044.1\|WP_011539593.1\|2387828_2388293_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NC_008044.1\|WP_011539605.1\|2403546_2404638_+\|ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|213620
NC_008044.1\|WP_011539598.1\|2392714_2394016_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NC_008044.1\|WP_011539604.1\|2402079_2403336_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NC_008044.1\|WP_011539603.1\|2400414_2401998_+\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|234864
NC_008044.1\|WP_011539607.1\|2406681_2407326_+\|cytochrome-o-ubiquinol-oxidase-subunit-III	unknown	unknown	gnl\|CDD\|131889

Protein	Function_ID	Function_description	E-value
NC_008044.1\|WP_011539596.1\|2390225_2391551_-\|glutamate--tRNA-ligase	gnl\|CDD\|183594	PRK12558, PRK12558, glutamyl-tRNA synthetase; Provisional.	0
NC_008044.1\|WP_011539595.1\|2388962_2390147_+\|DUF2254-domain-containing-protein	gnl\|CDD\|378351	pfam10011, DUF2254, Predicted membrane protein (DUF2254). Members of this family of bacterial proteins comprises various hypothetical and putative membrane proteins. Their exact function, has not, as yet, been defined.	1.3561e-109
NC_008044.1\|WP_011539608.1\|2407322_2407670_+\|cytochrome-o-ubiquinol-oxidase-subunit-IV	gnl\|CDD\|225667	COG3125, CyoD, Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion].	5.11992e-31
NC_008044.1\|WP_011539592.1\|2385285_2387814_+\|ABC-transporter-permease	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	0
NC_008044.1\|WP_044027248.1\|2394153_2395812_-\|NAD+-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NC_008044.1\|WP_011539591.1\|2384584_2385289_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226647	COG4181, COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism].	2.01285e-105
NC_008044.1\|WP_011539594.1\|2388396_2388966_+\|gamma-glutamylcyclotransferase	gnl\|CDD\|119400	cd06661, GGCT_like, GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).	2.3873e-08
NC_008044.1\|WP_011539590.1\|2383854_2384532_-\|arylesterase	gnl\|CDD\|238860	cd01822, Lysophospholipase_L1_like, Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity.	5.76155e-78
NC_008044.1\|WP_011539593.1\|2387828_2388293_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	8.55107e-42
NC_008044.1\|WP_011539597.1\|2391779_2392718_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293806	cd07720, OPHC2-like_MBL-fold, Pseudomonas pseudoalcaligenes organophosphorus hydrolase C2, and related proteins; MBL-fold metallo hydrolase domain. Pseudomonas pseudoalcaligenes OPHC2 is a thermostable organophosphorus hydrolase which a broad substrate activity spectrum: it hydrolyzes various phosphotriesters, esters, and a lactone. This subgroup also includes Pseudomonas oleovorans PoOPH which exhibits high lactonase and esterase activities, and latent PTE activity. However, double mutations His250Ile/Ile263Trp switch PoOPH into an efficient and thermostable PTE. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.42137e-82
NC_008044.1\|WP_011539606.1\|2404641_2406678_+\|cytochrome-o-ubiquinol-oxidase-subunit-I	gnl\|CDD\|131890	TIGR02843, Cytochrome_bo3_ubiquinol_oxidase_subunit_1, cytochrome o ubiquinol oxidase, subunit I. Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain which reacts with oxygen, reducing it to water with the concomitant transport of 4 protons across the membrane. Also known as the cytochrome bo complex, cytochrome o ubiquinol oxidase contains four subunits, two heme b cofactors and a copper atom which is believed to be the oxygen active site. This complex is structurally related to the cytochrome caa3 oxidases which utilize cytochrome c as the reductant and contain heme a cofactors, as well as the intermediate form aa3 oxidases which also react directly with quinones as the reductant. [Energy metabolism, Electron transport].	0
NC_008044.1\|WP_011539602.1\|2398531_2400055_-\|cryptochrome/photolyase-family-protein	gnl\|CDD\|225588	COG3046, COG3046, Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only].	0
NC_008044.1\|WP_011539609.1\|2407666_2408398_+\|Surfeit-locus-1	gnl\|CDD\|225883	COG3346, COG3346, Uncharacterized conserved protein [Function unknown].	1.37951e-50
NC_008044.1\|WP_011539610.1\|2408454_2408850_-\|VOC-family-protein	gnl\|CDD\|319900	cd07233, GlxI_Zn, Glyoxalase I that uses Zn(++) as cofactor. This family includes eukaryotic glyoxalase I that prefers the divalent cation zinc as cofactor. Glyoxalase I (also known as lactoylglutathione lyase; EC 4.4.1.5) is part of the glyoxalase system, a two-step system for detoxifying methylglyoxal, a side product of glycolysis. This system is responsible for the conversion of reactive, acyclic alpha-oxoaldehydes into the corresponding alpha-hydroxyacids and involves 2 enzymes, glyoxalase I and II. Glyoxalase I catalyses an intramolecular redox reaction of the hemithioacetal (formed from methylglyoxal and glutathione) to form the thioester, S-D-lactoylglutathione. This reaction involves the transfer of two hydrogen atoms from C1 to C2 of the methylglyoxal, and proceeds via an ene-diol intermediate. Glyoxalase I has a requirement for bound metal ions for catalysis. Eukaryotic glyoxalase I prefers the divalent cation zinc as cofactor, whereas Escherichia coil and other prokaryotic glyoxalase I uses nickel. However, eukaryotic Trypanosomatid parasites also use nickel as a cofactor, which could possibly be explained by acquiring their GLOI gene by horizontal gene transfer. Human glyoxalase I is a two-domain enzyme and it has the structure of a domain-swapped dimer with two active sites located at the dimer interface. In yeast, in various plants, insects and Plasmodia, glyoxalase I is four-domain, possibly the result of a further gene duplication and an additional gene fusing event.	6.8109e-20
NC_008044.1\|WP_011539605.1\|2403546_2404638_+\|ubiquinol-oxidase-subunit-II	gnl\|CDD\|213620	TIGR01433, precursor_Cytochrome_o_subunit_2_Oxidase, cytochrome o ubiquinol oxidase subunit II. This enzyme catalyzes the oxidation of ubiquinol with the concomitant reduction of molecular oxygen to water. This acts as the terminal electron acceptor in the respiratory chain. Subunit II is responsible for binding and oxidation of the ubiquinone substrate. This sequence is closely related to QoxA, which oxidizes quinol in gram positive bacteria but which is in complex with subunits which utilize cytochromes a in the reduction of molecular oxygen. Slightly more distantly related is subunit II of cytochrome c oxidase which uses cyt. c as the oxidant. [Energy metabolism, Electron transport].	3.64826e-115
NC_008044.1\|WP_011539598.1\|2392714_2394016_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	2.17949e-70
NC_008044.1\|WP_011539604.1\|2402079_2403336_-\|MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.57356e-79
NC_008044.1\|WP_011539603.1\|2400414_2401998_+\|2-isopropylmalate-synthase	gnl\|CDD\|234864	PRK00915, PRK00915, 2-isopropylmalate synthase; Validated.	0
NC_008044.1\|WP_011539607.1\|2406681_2407326_+\|cytochrome-o-ubiquinol-oxidase-subunit-III	gnl\|CDD\|131889	TIGR02842, Cytochrome_bo3_ubiquinol_oxidase_subunit_3, cytochrome o ubiquinol oxidase, subunit III. Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain which reacts with oxygen, reducing it to water with the concomitant transport of 4 protons across the membrane. Also known as the cytochrome bo complex, cytochrome o ubiquinol oxidase contains four subunits, two heme b cofactors and a copper atom which is believed to be the oxygen active site. This complex is structurally related to the cytochrome caa3 oxidases which utilize cytochrome c as the reductant and contain heme a cofactors, as well as the intermediate form aa3 oxidases which also react directly with quinones as the reductant. [Energy metabolism, Electron transport].	2.64602e-84

>NC_008044.1|WP_044027248.1|2394153_2395812_-|NAD+-synthase
MADSFRITLAQLNPTVGDLAGNAAKALSAWQEGRAADADLVALPEMFITGYNTQDLVMKPAFHQAAIAEVEALAKATAEGPALAIGSPWVEDGKLYNAYLILKGGKIASKCLKHHLPNETVFDEVRIFDAGPLGGPYSVGNTRIGSPICEDGWHEDVAETLEETGAEFLLIPNGSPYYRGKMETRINHMVARAVETGLPVIYLNMVGGQDDQVFDGGSFALNPHGALAVQMPVFDECIAQLDLERTADGWRIKEGEKAHLPDAWEQDYRTMVLSLRDYMGKTGFKKALLGLSGGVDSAIVAAIAVDALGAENVRCVMLPSEYTSKESLEDAEAVAKALGVHYDYVPISEGREAITNTLAPLFAGRDADLTEENIQSRLRGLLLMAMSNKFGEMLLTTGNKSEVAVGYATIYGDMNGGYNPIKDLYKTRVFETCRWRNANHRDWMMGPEGEVIRPNVIDKPPSAELREDQKDSDSLPDYPELDAILDILVDQEGSIADCVAAGFDRDVAKRVEHLLYISEYKRFQSAPGARLTKRAFWLDRRYPIVNRWRDPS
>NC_008044.1|WP_011539598.1|2392714_2394016_-|FAD-binding-oxidoreductase
MPGPQLPHFNSDRVLPKAVDVVIIGGGIVGASTALELAERGHSVLLCEKGQIAGEQSSRNWGWVRMSQRDPREMELMTHSQRIWEGLDMRTGYATGYTKCGIMFTAHTRKREAELSAWSEHLKAIGGEGHMLRGESLEQLTPGYGHRIRAGFYTPQDGCAEPQMATHAIASAARDKGAVVITGCAVRRLDVEAGRIRGVITEKGRVNATAVVVAGGAWSRLFLRNEGLFLPQLKVLNSVMRLSPVKGVPETALWAAGFGLRKRMDGGYTVASGGENTFDIVPDTFRIGHRFIPAFLRDVTALRFRVSDRWRIESAEARPWSGQDRSPFEETRVLDPQPSQKALRRGLAAVRDAFPALEKADVTQSWGGLIDVTPDEIPVISEVISRPGLFVSTGYSGHGFGLGPGAGRLTADLVTGDAPIVDPRPFRLSRFGA
>NC_008044.1|WP_011539597.1|2391779_2392718_+|MBL-fold-metallo-hydrolase
MTLKLSRRAALAGVAAAPIAAAVAAPARAAGHEAAKAPLHARAFKVGDYTVHSLLAGSTGRDGVKDIFGGGASDEAFSEVAAENFISDTSAQFYFTPTLVDTGSEKILFDTGLNAGGITKALADAGVTPEEVDVVVLTHMHGDHIGGMTDDSGAATFANARYVTAAAEYDHWTAMPEGNGGADRVRAKVAPQAEKMSFIDDGGAVASGVTGMAAFGHTPGHMVYMIESAGQQLLLTADLANHYVFPFAHPEWQTSFDTDKDAASATRRRVLEMLADSRTPMIGYHMPFPAAGYVERRGEGFRFVPVSYQMMG
>NC_008044.1|WP_011539596.1|2390225_2391551_-|glutamate--tRNA-ligase
MTTTRFAPSPTGYIHVGNLRTALMNYLIARKAGGTFILRIDDTDPERSKEEYVDAIKQDLEWLGITWDKVERQSERLDRYAEAADKLREIGRFYEAFETPTELDLKRKKQLNMGKPPVYDRAALALSDAEKESLRAERGNGVWRFKLDQERIEWTDGILGDISIDAASVSDPVLIRGDGQVLYTIASVVDDTDMGVTHVVRGSDHVTNTATQIQIMAALGHGHPEFAHHSLLTGPQGEALSKRLGTLALRDLREAGVKPMALLSLMARLGSSDPVELRTDMAELVDGFDINRFGSAPTKFDAEDLYPLTARYLQTLPVATVKSELDAIGVPADTQEAFWAVAKENITTLKDLEGWWILCRDGAEPLIADEDKEFIAEAMTLLPEGPYDSESWGKWTAAVKEKTGRKGKGLFMPLRKAVTGMERGPDMSALLALMQTVRARG
>NC_008044.1|WP_011539595.1|2388962_2390147_+|DUF2254-domain-containing-protein
MISRSLLLLRRITRQLWFRVVAISLFSLLALAIAPLLAPILPPAWEDRFGREAVLPVLTILASGMLAVTTFSLNVMVSAYRTASSMATPRVYRLLLEDTVTQSVLATFTGGFVYSLSAVILFRAGIYPPGSAFVVFVMTALVVMLIVLAILRWIDHLSDLGSMDHTLRLIESRSCSSLRARKETPCLGGCCLKTEPPSSASPIPASQSGFVRFVDMAALNRRAKEAGVTLYLTRLPGEFVLRGRPVAMAEGADEAFCKEASGLIDVGDVRSFEQDPTFGLTLLAETAQRALSPGVNDPGTAYEVMGRLTRLLWENLPEDSEATKSDADFPHIHLPPVTASALLKASFPPIALYAGDAPEVMDWMQTSLKALEHHPNAAMTRAAQEMRQDYFENS
>NC_008044.1|WP_011539594.1|2388396_2388966_+|gamma-glutamylcyclotransferase
MTPHFFGFGSLVNTATHVYGNTRPARLEGWRRTWVRTPDRSMAFLSVTPAPGHVIEGLLAAVPNGDWAALDERETGYVRVDVTPQVAHDMAPAPQISLYQVPEESHDRNARDHKILLSYLDVVLRGYREVFGDTGAEAFMATTDGWDTPILNDRATPYYPRHQVMTPDEHALHDALIAEAGAQVLAGGE
>NC_008044.1|WP_011539593.1|2387828_2388293_-|Rrf2-family-transcriptional-regulator
MRITKRTNIAVRLLMYCALNEGRLVTKSEIAARCNISENHLAQVVNQLSQLGFLKTQRGRNGGLALGRAAADICIGDVFRQVEGGLPMVECFADVDNTCPLVEACRLRDALTRAGEAFYGALDGISLESLTCDNIDLQRILSPLSCPSPAKTPA
>NC_008044.1|WP_011539592.1|2385285_2387814_+|ABC-transporter-permease
MSQKSSFRLAWRFALRELRGGLRGFRLFLACLALGVGVIAAIGSIRASIEAGLSREGASLLGGDAELTFTYRFANPDEIAWMDEIARDRSEVVEFRSMAVVGDERALTQVKSVDAAYPLRGDFRLMSGQPLHEALAAADGRPGAVMERVLADRLGLSEGSVFRLGTQEFRLSGLLEWEPDAAGSGFSIGPRTLVRTEALAQSGLLAPGTLYSTKYRLTLPPDADLAALEQDARARFEESGMRWRDARNGAPGIARFVERLGAFLVLVGLSGLAVGGVGVSTAVRAYLATKTETIATLRTLGSERRVIFLTYFLQIGVLSLCGITLGLILGGVGPLLLGPLIAAQLPFPAVFSIYPAALAESALYGVLTALLFTLWPLARTERIRAAALYRDAVSGGLQWPAPRYILATLATLGLLIAAAALFSGAPELALWTAGGLIGALVVLLIAGAAIGGLARMGNRMARGRPALRWALASIASARDGAMPAVLALGLGLTVLAAIGQIDGNMRRAIAGNLPDVAPSYFFVDIQRDQMPAFLERVEGDPQVSKVDNAPMLRGVITRINDRPAKEVAGDHWVIRGDRGVTYAAAKPASTNVTAGAWWPEDYTGPPQISFAAEEAEEMGLALGDTLTVNVLGRDITGTITSFREVDFSNAGMGFVLTMNEAALRGAPHSYIASVYAEEDAEAAILRDVAREMPNITAIRVRDAINRVSEILGQLATATAYGAAATLFTGFLVLLGTAAAAEPARRYEAALLKTLGAPRGQILRSFALRSAILGAAAGGVALLAGILGAWSVSHFVLETDYVVIWPNAVGVIGGGILVTLFAGLAYALRPLAARPARVLRARD
>NC_008044.1|WP_011539591.1|2384584_2385289_+|ABC-transporter-ATP-binding-protein
MSTDARPILTLQDVHLSLNGNTGPVRILEEISLEVQSGETLALVGPSGSGKSSLLMVMGGLEQATGGQVRAMGEDLTRLDEDALARFRRAHMGVVFQSFHLIPTMTALENVATPLELAGARDAFDRARDELEAVGLGHRCDHMPAQMSGGEQQRVALARAVVTRPEILLADEPTGNLDQANGAQVMDLLFDLRDRHGSTLVMVTHAPELAERCDRTIRLRDGRILTDAQREAAE
>NC_008044.1|WP_011539590.1|2383854_2384532_-|arylesterase
MRKFLKQIVVSLVSIPLLLGVAQAEPVRITAFGDSLVQGYGLPQGEGLVAQLRDWFAVEGFDVALTNAGVSGDTTAGGAARIDWTLAETPDAMIVLLGGNDLLRGLPPEDTRANLSRIIEAARGAGAEVLLIGMQAPGNYGADYKAAFDSIYPDLTATHDLVLHPFAFAGMAAEAGEDPAQMGAYMQADGIHPNARGVALNIKAMEPALHALMARLSQPEDSANN
>NC_008044.1|WP_011539601.1|2397494_2398535_+|hypothetical-protein
MATLLYLVHGAAVQQQQQLSYSVLSALKHGVDGVDLVLICDAANRRPDLPLRHVVISPEQIAQWTDGGRRPARAQLHALDLALRETGGPVCWASTDSAFTAAPARLLERITPETPLFFDRDGWLTSRPEWSPIIDACKDSALSEQIQPSTEVFDTGILGLSPSDLDFINQSLSPSFWPRIPNIFDNFEQIHLCALLAQNAQELRFSHDLVQRYQGYMRHVYQGRLEAMFPPGGAVNTALAAQLPAITEPPKPLHLRLKAKAYALRRGLGHGTEFGYLAYLCAFAAPTPEGRNVWANIALDMMERSARAPQKLVKDLSKLAPEALPDAELSPQTEERWRRYWMNAGL
>NC_008044.1|WP_011539602.1|2398531_2400055_-|cryptochrome/photolyase-family-protein
MTRLVLVLGDQLSEGLSALKAADPAHDVVVMAEVMDEGTYVPHHPKKIALVLAAMRKFAQRLEGQGWRVAYRRLDEDGAESIVGELLRRAEEFGASEVLATTPGEWRLIHALKYAPLKVHFHADDRFLATREDFTEWAEGKKQLRMEYFYRLMRKKTGLLMEGDTPVGGKWNYDSENRKAPPKIIDHKGPPRFEPDAEVEEVLDLVEARFGTHFGDLRPFWFATTREEAQEALAHFITHALPQFGDYQDAMMTDERWLYHSILSPYLNIGLLTPLEICEAAEVAHQDGHAPLNAVEGFIRQILGWREYVRGIYFLEGEDYPTRNALEQTRALPALYWGAETDMHCLSQAVEQTGQEAYAHHIQRLMVTGNFALLAGVDPAQVHEWYLAVYADAFEWVEAPNTVGMSQFADGGIIASKPYVSSGAYIDRMSNYCGSCAYKVKQKTGEGACPFNLLYWDFLNRHRARFEGNPRMGNMYRTWDRMDEEKRDVILQEASAFLAKLDAGERV
>NC_008044.1|WP_011539603.1|2400414_2401998_+|2-isopropylmalate-synthase
MTSKTDTVNQQDRVLIFDTTLRDGEQSPGATMTHDEKLEIAELLDDMGVDIIEAGFPIASEGDFKAVSEIAERSKNSVICGLARANFKDIDRCAEAVRKAAKPRIHTFIGTSPLHRAIPNLTMDEMAERIHDTVTHARNLVDNVQWSPMDATRTEWDYLCRVIEIAIKAGATTINIPDTVGYTAPRESADLIRRLIETVPGADEIIFATHCHNDLGMATANSLAAVEAGARQIECTINGLGERAGNTALEEVVMAMRVRNDIMPFQTGIDTKKIMHISRRVATVSGFNVQFNKAIVGKNAFAHESGIHQDGMLKNKETFEIMRPEDVGLAGTSLPLGKHSGRAALRDKLSSLGFEIGDNQLKDVFVRFKELADRKKEVFDDDIIALMRTSGDEDDHLKLVSMKVVCGTGGPAESTVEMEVDGKDVTETAEGDGPVDATFKAIRKIHPNAAHLQLYQVHAVTEGTDAQATVSVRLEEDGVIATGDSANTDTVVASAMAYIDALNRLIVRRDKMGEGADSREISYKDVD
>NC_008044.1|WP_011539604.1|2402079_2403336_-|MFS-transporter
MTTTEANAQHSDVTFDDVIITVVMARVTDFFGFFVYAIASALVFPAVFFPHLDPMMGTLWSFALFSLAFLARPIASLLGRRLQLVIGRAGKVTVALMILGVSTVAIGLLPGYEAWGIGAPIALAALRFMQGLGLGGAWDGITLQLKAAAPKGQSGLYSMVPQIGGPVGFCVAAALFYVLTGFLSEEEFLTYGWRFAFFAVMAVNVVSLFARLRLLSTNFAGDDEVVLRSAPLGELMSQEWRTIVLSALLPLASYALFHMVTVFPLSYSLLFTESNLSSILLLQLAGGTLAIVTVILSGVLADKFGRPVVLWISSALILLLCLSIGTLERAPAIYIIFGFVVLGLAYGQSSAIVPDRFKPQYRYSGAAMATNLSWILGAAFAPLCGLVLAWTFGLWAAALYLLSGVIVTAVALVLLQRQ
>NC_008044.1|WP_011539605.1|2403546_2404638_+|ubiquinol-oxidase-subunit-II
MRYLRFLCCALAFLTLSGCNLVLLSPSGDIAAQQGDLIVYSTVLMLIVIIPVMALTVFFAFKYRAENKDARYEPDWDHSVSLEIVVWFVPLAIIICLAGLTWVATHRLEPYDDLRRVSETKPIDPNVEPMEVQVVALDWKWLFIYPEYGVATVNEAAAIVDRPVEWKLTSSTVMNAFYIPEMAGMIYAMAGMETELNAVINEPGTFEGFSANYSGNGFSHMRFDFIAEDEAGFEAWIEEVRASGMTLDQDSYAVLEQPSVAHEVEYFGAVEDGLWDKILNMCAGPNALCLNDMMMVDALGGGGLAGLYNRELYRGICSADDPEALLAMLRPDIQEEQQREDILQAMTLTSGDLLPNSNTTEAN
>NC_008044.1|WP_011539606.1|2404641_2406678_+|cytochrome-o-ubiquinol-oxidase-subunit-I
MATIPAATAAAQSSDALNQTHWFWGKLGWDIFPFYDPIIFGTFIGTCILAAGVVGIVLYYRLLPYLWNEWFTTVDHKKIGIMYMILAVVMLVRGFADAVLMRLHQALASAGYVGFLPAYHYDQVFTAHGVIMIFFVAMPFITGFMNYVMPLQIGARDVAFPFLNNFSFWLTVSGAVLIMISLFVGEFAATGWLAYAPLSGLKFSPGVGMDYYLWSLNIAGIGTTLSGINLVVTLVKMRAPGMTWMKLPIFSWTTLCTNILIVVTFPVLTATLALLTADRYLGTHFFTNEMGGNPMMYVNLIWIWGHPEVYILILPIFGIFSEIVATFCGKRLFGYASMVYATCVIMVLSYIVWLHHFFTMGAGADVNSFFGITTMIISIPTGAKLFNWLFTMYKGRIRFELPMMWTIAFMLTFVVGGMTGVLLAVPPADYVLHNSLFLIAHFHNVIIGGVVFGIFAGITYWWPKAFGFHLDPFWGKVSFWGWVGGFWVAFMPLYLLGLMGVTRRLSQFEDTIYAGYFFTALIGALMIAVGLLAFLVQIFVSIRNREKLAVGNDPWGGRTLEWSTTSPPPYYNFAFTPRVYERDAWHHMKTHDAKAPTSGFVPIHMPHYTASGIILAGLMTVMGFALVWHIWWLSALMFLASLAYGIAHTFNYNRDYYVPAEEVSEIETGQRTVATPAE
>NC_008044.1|WP_011539607.1|2406681_2407326_+|cytochrome-o-ubiquinol-oxidase-subunit-III
MSHSAATPAPEALEFYVTEDPHAGHGDHHHDTGTMLGFWIYLMSDCLIFGILFAVHAVVGTSYAAGPSPADLFEIDKILLATFFLLFSSITYGFAVINMQQRKQRAMMLWLGVTLVFGLGFLVMEILEFQHLWHLGAGPGASAFLSSFWVLVGTHGLHVTAGAIWLVVLLVQVQMHGLTEANTRRILCLSMFWHFLDLIWIGVFSFVYLTGVLL
>NC_008044.1|WP_011539608.1|2407322_2407670_+|cytochrome-o-ubiquinol-oxidase-subunit-IV
MSAHSHGSYKSYAIGFVLSVILTVIPFWLVLGEVDIGVNTAIAVIFGLGAVQIIVHMHYFLHVTYGAEDGWQVMSLVFTGILLIIVLAGSIWVMAHLHENMMPAHEQIERVRNLP
>NC_008044.1|WP_011539609.1|2407666_2408398_+|Surfeit-locus-1
MSTGTSTEGGGRRRPFWVDAVILALAFGVFVTMVRLGNWQMQRLSWKLDLIEQVETRAFGPPVAAPIKGAAPEYQRVTLQGVFRHDLSLRIKAVTEIGPGSWVMTPIEGAEQTVWVNRGFVPPQMRLDEINRPEGLQEITGLIRSDQPGGTLLEQNLPDRDRWVSADLALMSADRGIEAAGYYIDAAHQGAAADWPRGGMTQLDFRNTHLSYALTWYAMAVLFFGAMAYVIWDRLRAPKERTS
>NC_008044.1|WP_011539610.1|2408454_2408850_-|VOC-family-protein
MTKLAHSMIRVLDETASVAFYKAAFDMEIADRLDFDDFTLIYLTAPEGSFELELTVNKSQTEAYDLGNGYGHLAVVVEDLEAARAKVETAGGAPRDIVDFRPAGERVARFFFVADPDGYQIEVIEAGGRFK

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Crispr_ID: NC_008044_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008044_3

2396855-2397016

Orphan

Consensus_repeat	Method
CCAATGGCGACGTCTACGAGGGCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_008044_3

>merge|NC_008044|3|2396855-2397016|CRISPRCasFinder
CGGATGGGTCCGTCTATGAGGGCGAATTCCGCGATGATCTGGCGCATGGGGTTGGCAAGATCACTTACCCCGATGGCTCCACCTACGAGGGCGAATGGGTCGCTGGCGTGATCGAAGGCAACGGCAAGGCGACCTACGCCAATGGCGCCATCTATGAGGGCA

>NC_008044|3|3|2396855-2397016|CRISPRCasFinder
CGGATGGGTCCGTCTATGAGGGCG	AATTCCGCGATGATCTGGCGCATGGGGTTGGCAAGATCACTTACC
CCGATGGCTCCACCTACGAGGGCG	AATGGGTCGCTGGCGTGATCGAAGGCAACGGCAAGGCGACCTACG
CCAATGGCGCCATCTATGAGGGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008044.1\|WP_011539596.1\|2390225_2391551_-\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|183594
NC_008044.1\|WP_011539595.1\|2388962_2390147_+\|DUF2254-domain-containing-protein	unknown	unknown	gnl\|CDD\|378351
NC_008044.1\|WP_011539608.1\|2407322_2407670_+\|cytochrome-o-ubiquinol-oxidase-subunit-IV	unknown	unknown	gnl\|CDD\|225667
NC_008044.1\|WP_011539592.1\|2385285_2387814_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225669
NC_008044.1\|WP_044027248.1\|2394153_2395812_-\|NAD+-synthase	unknown	unknown	gnl\|CDD\|237577
NC_008044.1\|WP_011539591.1\|2384584_2385289_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226647
NC_008044.1\|WP_011539594.1\|2388396_2388966_+\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|119400
NC_008044.1\|WP_011539590.1\|2383854_2384532_-\|arylesterase	unknown	unknown	gnl\|CDD\|238860
NC_008044.1\|WP_011539601.1\|2397494_2398535_+\|hypothetical-protein	unknown	unknown	unknown
NC_008044.1\|WP_011539597.1\|2391779_2392718_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293806
NC_008044.1\|WP_011539606.1\|2404641_2406678_+\|cytochrome-o-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|131890
NC_008044.1\|WP_011539602.1\|2398531_2400055_-\|cryptochrome/photolyase-family-protein	unknown	unknown	gnl\|CDD\|225588
NC_008044.1\|WP_011539609.1\|2407666_2408398_+\|Surfeit-locus-1	unknown	unknown	gnl\|CDD\|225883
NC_008044.1\|WP_011539610.1\|2408454_2408850_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319900
NC_008044.1\|WP_011539593.1\|2387828_2388293_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NC_008044.1\|WP_011539605.1\|2403546_2404638_+\|ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|213620
NC_008044.1\|WP_011539598.1\|2392714_2394016_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NC_008044.1\|WP_011539604.1\|2402079_2403336_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NC_008044.1\|WP_011539603.1\|2400414_2401998_+\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|234864
NC_008044.1\|WP_011539607.1\|2406681_2407326_+\|cytochrome-o-ubiquinol-oxidase-subunit-III	unknown	unknown	gnl\|CDD\|131889

Protein	Function_ID	Function_description	E-value
NC_008044.1\|WP_011539596.1\|2390225_2391551_-\|glutamate--tRNA-ligase	gnl\|CDD\|183594	PRK12558, PRK12558, glutamyl-tRNA synthetase; Provisional.	0
NC_008044.1\|WP_011539595.1\|2388962_2390147_+\|DUF2254-domain-containing-protein	gnl\|CDD\|378351	pfam10011, DUF2254, Predicted membrane protein (DUF2254). Members of this family of bacterial proteins comprises various hypothetical and putative membrane proteins. Their exact function, has not, as yet, been defined.	1.3561e-109
NC_008044.1\|WP_011539608.1\|2407322_2407670_+\|cytochrome-o-ubiquinol-oxidase-subunit-IV	gnl\|CDD\|225667	COG3125, CyoD, Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion].	5.11992e-31
NC_008044.1\|WP_011539592.1\|2385285_2387814_+\|ABC-transporter-permease	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	0
NC_008044.1\|WP_044027248.1\|2394153_2395812_-\|NAD+-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NC_008044.1\|WP_011539591.1\|2384584_2385289_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226647	COG4181, COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism].	2.01285e-105
NC_008044.1\|WP_011539594.1\|2388396_2388966_+\|gamma-glutamylcyclotransferase	gnl\|CDD\|119400	cd06661, GGCT_like, GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).	2.3873e-08
NC_008044.1\|WP_011539590.1\|2383854_2384532_-\|arylesterase	gnl\|CDD\|238860	cd01822, Lysophospholipase_L1_like, Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity.	5.76155e-78
NC_008044.1\|WP_011539593.1\|2387828_2388293_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	8.55107e-42
NC_008044.1\|WP_011539597.1\|2391779_2392718_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293806	cd07720, OPHC2-like_MBL-fold, Pseudomonas pseudoalcaligenes organophosphorus hydrolase C2, and related proteins; MBL-fold metallo hydrolase domain. Pseudomonas pseudoalcaligenes OPHC2 is a thermostable organophosphorus hydrolase which a broad substrate activity spectrum: it hydrolyzes various phosphotriesters, esters, and a lactone. This subgroup also includes Pseudomonas oleovorans PoOPH which exhibits high lactonase and esterase activities, and latent PTE activity. However, double mutations His250Ile/Ile263Trp switch PoOPH into an efficient and thermostable PTE. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.42137e-82
NC_008044.1\|WP_011539606.1\|2404641_2406678_+\|cytochrome-o-ubiquinol-oxidase-subunit-I	gnl\|CDD\|131890	TIGR02843, Cytochrome_bo3_ubiquinol_oxidase_subunit_1, cytochrome o ubiquinol oxidase, subunit I. Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain which reacts with oxygen, reducing it to water with the concomitant transport of 4 protons across the membrane. Also known as the cytochrome bo complex, cytochrome o ubiquinol oxidase contains four subunits, two heme b cofactors and a copper atom which is believed to be the oxygen active site. This complex is structurally related to the cytochrome caa3 oxidases which utilize cytochrome c as the reductant and contain heme a cofactors, as well as the intermediate form aa3 oxidases which also react directly with quinones as the reductant. [Energy metabolism, Electron transport].	0
NC_008044.1\|WP_011539602.1\|2398531_2400055_-\|cryptochrome/photolyase-family-protein	gnl\|CDD\|225588	COG3046, COG3046, Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only].	0
NC_008044.1\|WP_011539609.1\|2407666_2408398_+\|Surfeit-locus-1	gnl\|CDD\|225883	COG3346, COG3346, Uncharacterized conserved protein [Function unknown].	1.37951e-50
NC_008044.1\|WP_011539610.1\|2408454_2408850_-\|VOC-family-protein	gnl\|CDD\|319900	cd07233, GlxI_Zn, Glyoxalase I that uses Zn(++) as cofactor. This family includes eukaryotic glyoxalase I that prefers the divalent cation zinc as cofactor. Glyoxalase I (also known as lactoylglutathione lyase; EC 4.4.1.5) is part of the glyoxalase system, a two-step system for detoxifying methylglyoxal, a side product of glycolysis. This system is responsible for the conversion of reactive, acyclic alpha-oxoaldehydes into the corresponding alpha-hydroxyacids and involves 2 enzymes, glyoxalase I and II. Glyoxalase I catalyses an intramolecular redox reaction of the hemithioacetal (formed from methylglyoxal and glutathione) to form the thioester, S-D-lactoylglutathione. This reaction involves the transfer of two hydrogen atoms from C1 to C2 of the methylglyoxal, and proceeds via an ene-diol intermediate. Glyoxalase I has a requirement for bound metal ions for catalysis. Eukaryotic glyoxalase I prefers the divalent cation zinc as cofactor, whereas Escherichia coil and other prokaryotic glyoxalase I uses nickel. However, eukaryotic Trypanosomatid parasites also use nickel as a cofactor, which could possibly be explained by acquiring their GLOI gene by horizontal gene transfer. Human glyoxalase I is a two-domain enzyme and it has the structure of a domain-swapped dimer with two active sites located at the dimer interface. In yeast, in various plants, insects and Plasmodia, glyoxalase I is four-domain, possibly the result of a further gene duplication and an additional gene fusing event.	6.8109e-20
NC_008044.1\|WP_011539605.1\|2403546_2404638_+\|ubiquinol-oxidase-subunit-II	gnl\|CDD\|213620	TIGR01433, precursor_Cytochrome_o_subunit_2_Oxidase, cytochrome o ubiquinol oxidase subunit II. This enzyme catalyzes the oxidation of ubiquinol with the concomitant reduction of molecular oxygen to water. This acts as the terminal electron acceptor in the respiratory chain. Subunit II is responsible for binding and oxidation of the ubiquinone substrate. This sequence is closely related to QoxA, which oxidizes quinol in gram positive bacteria but which is in complex with subunits which utilize cytochromes a in the reduction of molecular oxygen. Slightly more distantly related is subunit II of cytochrome c oxidase which uses cyt. c as the oxidant. [Energy metabolism, Electron transport].	3.64826e-115
NC_008044.1\|WP_011539598.1\|2392714_2394016_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	2.17949e-70
NC_008044.1\|WP_011539604.1\|2402079_2403336_-\|MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.57356e-79
NC_008044.1\|WP_011539603.1\|2400414_2401998_+\|2-isopropylmalate-synthase	gnl\|CDD\|234864	PRK00915, PRK00915, 2-isopropylmalate synthase; Validated.	0
NC_008044.1\|WP_011539607.1\|2406681_2407326_+\|cytochrome-o-ubiquinol-oxidase-subunit-III	gnl\|CDD\|131889	TIGR02842, Cytochrome_bo3_ubiquinol_oxidase_subunit_3, cytochrome o ubiquinol oxidase, subunit III. Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain which reacts with oxygen, reducing it to water with the concomitant transport of 4 protons across the membrane. Also known as the cytochrome bo complex, cytochrome o ubiquinol oxidase contains four subunits, two heme b cofactors and a copper atom which is believed to be the oxygen active site. This complex is structurally related to the cytochrome caa3 oxidases which utilize cytochrome c as the reductant and contain heme a cofactors, as well as the intermediate form aa3 oxidases which also react directly with quinones as the reductant. [Energy metabolism, Electron transport].	2.64602e-84

>NC_008044.1|WP_044027248.1|2394153_2395812_-|NAD+-synthase
MADSFRITLAQLNPTVGDLAGNAAKALSAWQEGRAADADLVALPEMFITGYNTQDLVMKPAFHQAAIAEVEALAKATAEGPALAIGSPWVEDGKLYNAYLILKGGKIASKCLKHHLPNETVFDEVRIFDAGPLGGPYSVGNTRIGSPICEDGWHEDVAETLEETGAEFLLIPNGSPYYRGKMETRINHMVARAVETGLPVIYLNMVGGQDDQVFDGGSFALNPHGALAVQMPVFDECIAQLDLERTADGWRIKEGEKAHLPDAWEQDYRTMVLSLRDYMGKTGFKKALLGLSGGVDSAIVAAIAVDALGAENVRCVMLPSEYTSKESLEDAEAVAKALGVHYDYVPISEGREAITNTLAPLFAGRDADLTEENIQSRLRGLLLMAMSNKFGEMLLTTGNKSEVAVGYATIYGDMNGGYNPIKDLYKTRVFETCRWRNANHRDWMMGPEGEVIRPNVIDKPPSAELREDQKDSDSLPDYPELDAILDILVDQEGSIADCVAAGFDRDVAKRVEHLLYISEYKRFQSAPGARLTKRAFWLDRRYPIVNRWRDPS
>NC_008044.1|WP_011539598.1|2392714_2394016_-|FAD-binding-oxidoreductase
MPGPQLPHFNSDRVLPKAVDVVIIGGGIVGASTALELAERGHSVLLCEKGQIAGEQSSRNWGWVRMSQRDPREMELMTHSQRIWEGLDMRTGYATGYTKCGIMFTAHTRKREAELSAWSEHLKAIGGEGHMLRGESLEQLTPGYGHRIRAGFYTPQDGCAEPQMATHAIASAARDKGAVVITGCAVRRLDVEAGRIRGVITEKGRVNATAVVVAGGAWSRLFLRNEGLFLPQLKVLNSVMRLSPVKGVPETALWAAGFGLRKRMDGGYTVASGGENTFDIVPDTFRIGHRFIPAFLRDVTALRFRVSDRWRIESAEARPWSGQDRSPFEETRVLDPQPSQKALRRGLAAVRDAFPALEKADVTQSWGGLIDVTPDEIPVISEVISRPGLFVSTGYSGHGFGLGPGAGRLTADLVTGDAPIVDPRPFRLSRFGA
>NC_008044.1|WP_011539597.1|2391779_2392718_+|MBL-fold-metallo-hydrolase
MTLKLSRRAALAGVAAAPIAAAVAAPARAAGHEAAKAPLHARAFKVGDYTVHSLLAGSTGRDGVKDIFGGGASDEAFSEVAAENFISDTSAQFYFTPTLVDTGSEKILFDTGLNAGGITKALADAGVTPEEVDVVVLTHMHGDHIGGMTDDSGAATFANARYVTAAAEYDHWTAMPEGNGGADRVRAKVAPQAEKMSFIDDGGAVASGVTGMAAFGHTPGHMVYMIESAGQQLLLTADLANHYVFPFAHPEWQTSFDTDKDAASATRRRVLEMLADSRTPMIGYHMPFPAAGYVERRGEGFRFVPVSYQMMG
>NC_008044.1|WP_011539596.1|2390225_2391551_-|glutamate--tRNA-ligase
MTTTRFAPSPTGYIHVGNLRTALMNYLIARKAGGTFILRIDDTDPERSKEEYVDAIKQDLEWLGITWDKVERQSERLDRYAEAADKLREIGRFYEAFETPTELDLKRKKQLNMGKPPVYDRAALALSDAEKESLRAERGNGVWRFKLDQERIEWTDGILGDISIDAASVSDPVLIRGDGQVLYTIASVVDDTDMGVTHVVRGSDHVTNTATQIQIMAALGHGHPEFAHHSLLTGPQGEALSKRLGTLALRDLREAGVKPMALLSLMARLGSSDPVELRTDMAELVDGFDINRFGSAPTKFDAEDLYPLTARYLQTLPVATVKSELDAIGVPADTQEAFWAVAKENITTLKDLEGWWILCRDGAEPLIADEDKEFIAEAMTLLPEGPYDSESWGKWTAAVKEKTGRKGKGLFMPLRKAVTGMERGPDMSALLALMQTVRARG
>NC_008044.1|WP_011539595.1|2388962_2390147_+|DUF2254-domain-containing-protein
MISRSLLLLRRITRQLWFRVVAISLFSLLALAIAPLLAPILPPAWEDRFGREAVLPVLTILASGMLAVTTFSLNVMVSAYRTASSMATPRVYRLLLEDTVTQSVLATFTGGFVYSLSAVILFRAGIYPPGSAFVVFVMTALVVMLIVLAILRWIDHLSDLGSMDHTLRLIESRSCSSLRARKETPCLGGCCLKTEPPSSASPIPASQSGFVRFVDMAALNRRAKEAGVTLYLTRLPGEFVLRGRPVAMAEGADEAFCKEASGLIDVGDVRSFEQDPTFGLTLLAETAQRALSPGVNDPGTAYEVMGRLTRLLWENLPEDSEATKSDADFPHIHLPPVTASALLKASFPPIALYAGDAPEVMDWMQTSLKALEHHPNAAMTRAAQEMRQDYFENS
>NC_008044.1|WP_011539594.1|2388396_2388966_+|gamma-glutamylcyclotransferase
MTPHFFGFGSLVNTATHVYGNTRPARLEGWRRTWVRTPDRSMAFLSVTPAPGHVIEGLLAAVPNGDWAALDERETGYVRVDVTPQVAHDMAPAPQISLYQVPEESHDRNARDHKILLSYLDVVLRGYREVFGDTGAEAFMATTDGWDTPILNDRATPYYPRHQVMTPDEHALHDALIAEAGAQVLAGGE
>NC_008044.1|WP_011539593.1|2387828_2388293_-|Rrf2-family-transcriptional-regulator
MRITKRTNIAVRLLMYCALNEGRLVTKSEIAARCNISENHLAQVVNQLSQLGFLKTQRGRNGGLALGRAAADICIGDVFRQVEGGLPMVECFADVDNTCPLVEACRLRDALTRAGEAFYGALDGISLESLTCDNIDLQRILSPLSCPSPAKTPA
>NC_008044.1|WP_011539592.1|2385285_2387814_+|ABC-transporter-permease
MSQKSSFRLAWRFALRELRGGLRGFRLFLACLALGVGVIAAIGSIRASIEAGLSREGASLLGGDAELTFTYRFANPDEIAWMDEIARDRSEVVEFRSMAVVGDERALTQVKSVDAAYPLRGDFRLMSGQPLHEALAAADGRPGAVMERVLADRLGLSEGSVFRLGTQEFRLSGLLEWEPDAAGSGFSIGPRTLVRTEALAQSGLLAPGTLYSTKYRLTLPPDADLAALEQDARARFEESGMRWRDARNGAPGIARFVERLGAFLVLVGLSGLAVGGVGVSTAVRAYLATKTETIATLRTLGSERRVIFLTYFLQIGVLSLCGITLGLILGGVGPLLLGPLIAAQLPFPAVFSIYPAALAESALYGVLTALLFTLWPLARTERIRAAALYRDAVSGGLQWPAPRYILATLATLGLLIAAAALFSGAPELALWTAGGLIGALVVLLIAGAAIGGLARMGNRMARGRPALRWALASIASARDGAMPAVLALGLGLTVLAAIGQIDGNMRRAIAGNLPDVAPSYFFVDIQRDQMPAFLERVEGDPQVSKVDNAPMLRGVITRINDRPAKEVAGDHWVIRGDRGVTYAAAKPASTNVTAGAWWPEDYTGPPQISFAAEEAEEMGLALGDTLTVNVLGRDITGTITSFREVDFSNAGMGFVLTMNEAALRGAPHSYIASVYAEEDAEAAILRDVAREMPNITAIRVRDAINRVSEILGQLATATAYGAAATLFTGFLVLLGTAAAAEPARRYEAALLKTLGAPRGQILRSFALRSAILGAAAGGVALLAGILGAWSVSHFVLETDYVVIWPNAVGVIGGGILVTLFAGLAYALRPLAARPARVLRARD
>NC_008044.1|WP_011539591.1|2384584_2385289_+|ABC-transporter-ATP-binding-protein
MSTDARPILTLQDVHLSLNGNTGPVRILEEISLEVQSGETLALVGPSGSGKSSLLMVMGGLEQATGGQVRAMGEDLTRLDEDALARFRRAHMGVVFQSFHLIPTMTALENVATPLELAGARDAFDRARDELEAVGLGHRCDHMPAQMSGGEQQRVALARAVVTRPEILLADEPTGNLDQANGAQVMDLLFDLRDRHGSTLVMVTHAPELAERCDRTIRLRDGRILTDAQREAAE
>NC_008044.1|WP_011539590.1|2383854_2384532_-|arylesterase
MRKFLKQIVVSLVSIPLLLGVAQAEPVRITAFGDSLVQGYGLPQGEGLVAQLRDWFAVEGFDVALTNAGVSGDTTAGGAARIDWTLAETPDAMIVLLGGNDLLRGLPPEDTRANLSRIIEAARGAGAEVLLIGMQAPGNYGADYKAAFDSIYPDLTATHDLVLHPFAFAGMAAEAGEDPAQMGAYMQADGIHPNARGVALNIKAMEPALHALMARLSQPEDSANN
>NC_008044.1|WP_011539601.1|2397494_2398535_+|hypothetical-protein
MATLLYLVHGAAVQQQQQLSYSVLSALKHGVDGVDLVLICDAANRRPDLPLRHVVISPEQIAQWTDGGRRPARAQLHALDLALRETGGPVCWASTDSAFTAAPARLLERITPETPLFFDRDGWLTSRPEWSPIIDACKDSALSEQIQPSTEVFDTGILGLSPSDLDFINQSLSPSFWPRIPNIFDNFEQIHLCALLAQNAQELRFSHDLVQRYQGYMRHVYQGRLEAMFPPGGAVNTALAAQLPAITEPPKPLHLRLKAKAYALRRGLGHGTEFGYLAYLCAFAAPTPEGRNVWANIALDMMERSARAPQKLVKDLSKLAPEALPDAELSPQTEERWRRYWMNAGL
>NC_008044.1|WP_011539602.1|2398531_2400055_-|cryptochrome/photolyase-family-protein
MTRLVLVLGDQLSEGLSALKAADPAHDVVVMAEVMDEGTYVPHHPKKIALVLAAMRKFAQRLEGQGWRVAYRRLDEDGAESIVGELLRRAEEFGASEVLATTPGEWRLIHALKYAPLKVHFHADDRFLATREDFTEWAEGKKQLRMEYFYRLMRKKTGLLMEGDTPVGGKWNYDSENRKAPPKIIDHKGPPRFEPDAEVEEVLDLVEARFGTHFGDLRPFWFATTREEAQEALAHFITHALPQFGDYQDAMMTDERWLYHSILSPYLNIGLLTPLEICEAAEVAHQDGHAPLNAVEGFIRQILGWREYVRGIYFLEGEDYPTRNALEQTRALPALYWGAETDMHCLSQAVEQTGQEAYAHHIQRLMVTGNFALLAGVDPAQVHEWYLAVYADAFEWVEAPNTVGMSQFADGGIIASKPYVSSGAYIDRMSNYCGSCAYKVKQKTGEGACPFNLLYWDFLNRHRARFEGNPRMGNMYRTWDRMDEEKRDVILQEASAFLAKLDAGERV
>NC_008044.1|WP_011539603.1|2400414_2401998_+|2-isopropylmalate-synthase
MTSKTDTVNQQDRVLIFDTTLRDGEQSPGATMTHDEKLEIAELLDDMGVDIIEAGFPIASEGDFKAVSEIAERSKNSVICGLARANFKDIDRCAEAVRKAAKPRIHTFIGTSPLHRAIPNLTMDEMAERIHDTVTHARNLVDNVQWSPMDATRTEWDYLCRVIEIAIKAGATTINIPDTVGYTAPRESADLIRRLIETVPGADEIIFATHCHNDLGMATANSLAAVEAGARQIECTINGLGERAGNTALEEVVMAMRVRNDIMPFQTGIDTKKIMHISRRVATVSGFNVQFNKAIVGKNAFAHESGIHQDGMLKNKETFEIMRPEDVGLAGTSLPLGKHSGRAALRDKLSSLGFEIGDNQLKDVFVRFKELADRKKEVFDDDIIALMRTSGDEDDHLKLVSMKVVCGTGGPAESTVEMEVDGKDVTETAEGDGPVDATFKAIRKIHPNAAHLQLYQVHAVTEGTDAQATVSVRLEEDGVIATGDSANTDTVVASAMAYIDALNRLIVRRDKMGEGADSREISYKDVD
>NC_008044.1|WP_011539604.1|2402079_2403336_-|MFS-transporter
MTTTEANAQHSDVTFDDVIITVVMARVTDFFGFFVYAIASALVFPAVFFPHLDPMMGTLWSFALFSLAFLARPIASLLGRRLQLVIGRAGKVTVALMILGVSTVAIGLLPGYEAWGIGAPIALAALRFMQGLGLGGAWDGITLQLKAAAPKGQSGLYSMVPQIGGPVGFCVAAALFYVLTGFLSEEEFLTYGWRFAFFAVMAVNVVSLFARLRLLSTNFAGDDEVVLRSAPLGELMSQEWRTIVLSALLPLASYALFHMVTVFPLSYSLLFTESNLSSILLLQLAGGTLAIVTVILSGVLADKFGRPVVLWISSALILLLCLSIGTLERAPAIYIIFGFVVLGLAYGQSSAIVPDRFKPQYRYSGAAMATNLSWILGAAFAPLCGLVLAWTFGLWAAALYLLSGVIVTAVALVLLQRQ
>NC_008044.1|WP_011539605.1|2403546_2404638_+|ubiquinol-oxidase-subunit-II
MRYLRFLCCALAFLTLSGCNLVLLSPSGDIAAQQGDLIVYSTVLMLIVIIPVMALTVFFAFKYRAENKDARYEPDWDHSVSLEIVVWFVPLAIIICLAGLTWVATHRLEPYDDLRRVSETKPIDPNVEPMEVQVVALDWKWLFIYPEYGVATVNEAAAIVDRPVEWKLTSSTVMNAFYIPEMAGMIYAMAGMETELNAVINEPGTFEGFSANYSGNGFSHMRFDFIAEDEAGFEAWIEEVRASGMTLDQDSYAVLEQPSVAHEVEYFGAVEDGLWDKILNMCAGPNALCLNDMMMVDALGGGGLAGLYNRELYRGICSADDPEALLAMLRPDIQEEQQREDILQAMTLTSGDLLPNSNTTEAN
>NC_008044.1|WP_011539606.1|2404641_2406678_+|cytochrome-o-ubiquinol-oxidase-subunit-I
MATIPAATAAAQSSDALNQTHWFWGKLGWDIFPFYDPIIFGTFIGTCILAAGVVGIVLYYRLLPYLWNEWFTTVDHKKIGIMYMILAVVMLVRGFADAVLMRLHQALASAGYVGFLPAYHYDQVFTAHGVIMIFFVAMPFITGFMNYVMPLQIGARDVAFPFLNNFSFWLTVSGAVLIMISLFVGEFAATGWLAYAPLSGLKFSPGVGMDYYLWSLNIAGIGTTLSGINLVVTLVKMRAPGMTWMKLPIFSWTTLCTNILIVVTFPVLTATLALLTADRYLGTHFFTNEMGGNPMMYVNLIWIWGHPEVYILILPIFGIFSEIVATFCGKRLFGYASMVYATCVIMVLSYIVWLHHFFTMGAGADVNSFFGITTMIISIPTGAKLFNWLFTMYKGRIRFELPMMWTIAFMLTFVVGGMTGVLLAVPPADYVLHNSLFLIAHFHNVIIGGVVFGIFAGITYWWPKAFGFHLDPFWGKVSFWGWVGGFWVAFMPLYLLGLMGVTRRLSQFEDTIYAGYFFTALIGALMIAVGLLAFLVQIFVSIRNREKLAVGNDPWGGRTLEWSTTSPPPYYNFAFTPRVYERDAWHHMKTHDAKAPTSGFVPIHMPHYTASGIILAGLMTVMGFALVWHIWWLSALMFLASLAYGIAHTFNYNRDYYVPAEEVSEIETGQRTVATPAE
>NC_008044.1|WP_011539607.1|2406681_2407326_+|cytochrome-o-ubiquinol-oxidase-subunit-III
MSHSAATPAPEALEFYVTEDPHAGHGDHHHDTGTMLGFWIYLMSDCLIFGILFAVHAVVGTSYAAGPSPADLFEIDKILLATFFLLFSSITYGFAVINMQQRKQRAMMLWLGVTLVFGLGFLVMEILEFQHLWHLGAGPGASAFLSSFWVLVGTHGLHVTAGAIWLVVLLVQVQMHGLTEANTRRILCLSMFWHFLDLIWIGVFSFVYLTGVLL
>NC_008044.1|WP_011539608.1|2407322_2407670_+|cytochrome-o-ubiquinol-oxidase-subunit-IV
MSAHSHGSYKSYAIGFVLSVILTVIPFWLVLGEVDIGVNTAIAVIFGLGAVQIIVHMHYFLHVTYGAEDGWQVMSLVFTGILLIIVLAGSIWVMAHLHENMMPAHEQIERVRNLP
>NC_008044.1|WP_011539609.1|2407666_2408398_+|Surfeit-locus-1
MSTGTSTEGGGRRRPFWVDAVILALAFGVFVTMVRLGNWQMQRLSWKLDLIEQVETRAFGPPVAAPIKGAAPEYQRVTLQGVFRHDLSLRIKAVTEIGPGSWVMTPIEGAEQTVWVNRGFVPPQMRLDEINRPEGLQEITGLIRSDQPGGTLLEQNLPDRDRWVSADLALMSADRGIEAAGYYIDAAHQGAAADWPRGGMTQLDFRNTHLSYALTWYAMAVLFFGAMAYVIWDRLRAPKERTS
>NC_008044.1|WP_011539610.1|2408454_2408850_-|VOC-family-protein
MTKLAHSMIRVLDETASVAFYKAAFDMEIADRLDFDDFTLIYLTAPEGSFELELTVNKSQTEAYDLGNGYGHLAVVVEDLEAARAKVETAGGAPRDIVDFRPAGERVARFFFVADPDGYQIEVIEAGGRFK

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Crispr_ID: NC_008044_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008044_4

2801641-2801730

Orphan

Consensus_repeat	Method
GGTTCCCACTTTTGCGCGACATGCTCTTGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008044_4

>merge|NC_008044|4|2801641-2801730|CRISPRCasFinder
GGTTCCCACTTTTGCGCGACATGCTCTTGGTAATGCCGCATGTCTGAGGTCGCAAAACCGGTTCCCACTTTTGCGCGACATGCTCTATGG

>NC_008044|4|4|2801641-2801730|CRISPRCasFinder
GGTTCCCACTTTTGCGCGACATGCTCTTGGT	AATGCCGCATGTCTGAGGTCGCAAAACC
GGTTCCCACTTTTGCGCGACATGCTCTATGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008044.1\|WP_193339816.1\|2797147_2798515_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225179
NC_008044.1\|WP_011539979.1\|2800488_2801121_+\|queuosine-precursor-transporter	unknown	unknown	gnl\|CDD\|183041
NC_008044.1\|WP_011539978.1\|2799407_2800334_+\|esterase-like-activity-of-phytase-family-protein	unknown	unknown	gnl\|CDD\|379191
NC_008044.1\|WP_011539975.1\|2796503_2797082_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|238329
NC_008044.1\|WP_044027285.1\|2808674_2809748_+\|cell-division-protein-ZapE	unknown	unknown	gnl\|CDD\|224402
NC_008044.1\|WP_011539970.1\|2791375_2792497_-\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224662
NC_008044.1\|WP_011539983.1\|2804810_2805431_+\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|319790
NC_008044.1\|WP_011539985.1\|2806341_2807274_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_008044.1\|WP_011539973.1\|2793913_2795953_-\|DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|223588
NC_008044.1\|WP_011539981.1\|2802297_2803320_+\|P1-family-peptidase	unknown	unknown	gnl\|CDD\|225732
NC_008044.1\|WP_011539986.1\|2807276_2808515_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340913
NC_008044.1\|WP_011539971.1\|2792624_2793053_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NC_008044.1\|WP_011539988.1\|2809875_2810637_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_008044.1\|WP_011539972.1\|2793056_2793812_-\|YaaA-family-protein	unknown	unknown	gnl\|CDD\|377151
NC_008044.1\|WP_011539984.1\|2805427_2806345_+\|ornithine-cyclodeaminase	unknown	unknown	gnl\|CDD\|180421
NC_008044.1\|WP_011539977.1\|2798511_2799435_+\|penicillin-insensitive-murein-endopeptidase	unknown	unknown	gnl\|CDD\|236511
NC_008044.1\|WP_011539982.1\|2803832_2804795_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NC_008044.1\|WP_011539989.1\|2810633_2811905_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	unknown	unknown	gnl\|CDD\|223362
NC_008044.1\|WP_011539980.1\|2801737_2802157_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|181730
NC_008044.1\|WP_044027283.1\|2796081_2796369_-\|YggT-family-protein	unknown	unknown	gnl\|CDD\|376765

Protein	Function_ID	Function_description	E-value
NC_008044.1\|WP_193339816.1\|2797147_2798515_+\|MFS-transporter	gnl\|CDD\|225179	COG2270, COG2270, Permeases of the major facilitator superfamily [General function prediction only].	7.1133e-85
NC_008044.1\|WP_011539979.1\|2800488_2801121_+\|queuosine-precursor-transporter	gnl\|CDD\|183041	PRK11212, PRK11212, 7-cyano-7-deazaguanine/7-aminomethyl-7-deazaguanine transporter.	4.92453e-32
NC_008044.1\|WP_011539978.1\|2799407_2800334_+\|esterase-like-activity-of-phytase-family-protein	gnl\|CDD\|379191	pfam13449, Phytase-like, Esterase-like activity of phytase. This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins.	5.159e-44
NC_008044.1\|WP_011539975.1\|2796503_2797082_+\|acyl-CoA-thioesterase	gnl\|CDD\|238329	cd00586, 4HBT, 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).	5.89125e-18
NC_008044.1\|WP_044027285.1\|2808674_2809748_+\|cell-division-protein-ZapE	gnl\|CDD\|224402	COG1485, COG1485, Predicted ATPase [General function prediction only].	2.89748e-143
NC_008044.1\|WP_011539970.1\|2791375_2792497_-\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	gnl\|CDD\|224662	COG1748, LYS9, Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism].	1.17469e-80
NC_008044.1\|WP_011539983.1\|2804810_2805431_+\|HAD-family-phosphatase	gnl\|CDD\|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.62306e-39
NC_008044.1\|WP_011539985.1\|2806341_2807274_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	3.17877e-25
NC_008044.1\|WP_011539973.1\|2793913_2795953_-\|DNA-helicase-RecQ	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	0
NC_008044.1\|WP_011539981.1\|2802297_2803320_+\|P1-family-peptidase	gnl\|CDD\|225732	COG3191, DmpA, L-aminopeptidase/D-esterase [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	4.79975e-80
NC_008044.1\|WP_011539986.1\|2807276_2808515_-\|MFS-transporter	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.16726e-80
NC_008044.1\|WP_011539971.1\|2792624_2793053_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	2.23209e-30
NC_008044.1\|WP_011539988.1\|2809875_2810637_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.64012e-64
NC_008044.1\|WP_011539972.1\|2793056_2793812_-\|YaaA-family-protein	gnl\|CDD\|377151	pfam03883, H2O2_YaaD, Peroxide stress protein YaaA. YaaA is a key element of the stress response to H2O2. It acts by reducing the level of intracellular iron levels after peroxide stress, thereby attenuating the Fenton reaction and the DNA damage that this would cause. The molecular mechanism of action is not known.	2.47025e-102
NC_008044.1\|WP_011539984.1\|2805427_2806345_+\|ornithine-cyclodeaminase	gnl\|CDD\|180421	PRK06141, PRK06141, ornithine cyclodeaminase family protein.	1.29384e-74
NC_008044.1\|WP_011539977.1\|2798511_2799435_+\|penicillin-insensitive-murein-endopeptidase	gnl\|CDD\|236511	PRK09429, mepA, penicillin-insensitive murein endopeptidase; Reviewed.	1.41116e-142
NC_008044.1\|WP_011539982.1\|2803832_2804795_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	8.74825e-12
NC_008044.1\|WP_011539989.1\|2810633_2811905_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	gnl\|CDD\|223362	COG0285, FolC, Folylpolyglutamate synthase [Coenzyme metabolism].	2.70703e-142
NC_008044.1\|WP_011539980.1\|2801737_2802157_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|181730	PRK09256, PRK09256, aminoacyl-tRNA hydrolase.	3.88346e-64
NC_008044.1\|WP_044027283.1\|2796081_2796369_-\|YggT-family-protein	gnl\|CDD\|376765	pfam02325, YGGT, YGGT family. This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown.	4.21654e-06

>NC_008044.1|WP_011539979.1|2800488_2801121_+|queuosine-precursor-transporter
MTRTYLPGVLAMAAVVVASNILVQFLFGNWLTWGAFTYPIAFLVTDVTNRVYGAGPARKVVLAGFVVGVICSLIGTQIMGEFGPLVTLRIAVASGLAFLLAQLTDVAIFASLRGGKWWRAPLASTLIGSSLDTAIFFTIAFSGALTFLEPANDVSWAGEMLPLLGAGPVAPLWVSLAVADWLVKLSLALIALIPFRLIVARLTQGQPSKA
>NC_008044.1|WP_011539978.1|2799407_2800334_+|esterase-like-activity-of-phytase-family-protein
MRRRSFIRLASVAIGLLVALCAAALAASTVWSVTHADSNSARLVSSYRWHEDAPWFGGMSGLELSEDGTRFVAITDRSHLVKGEIIRQDGDITGLRMTEQHRLRNAGGARMPEDVEDSEGLVVQGAQMFVSFESPHRVLEYNATEVRQLPSPRGFRRFSFNASFEALAQSPEGDLVLIAESPPRNKNVSRVWRWSGAEGWQGLGPYPEADGFLPVGADFGPDGALYVLERKFAKIGFRSRLRRFDLTAKGLGGGEILLNTPLARHDNLEGLSIWRTPSGNLRATMISDDNFFWVQRTELVEYDLPARP
>NC_008044.1|WP_011539977.1|2798511_2799435_+|penicillin-insensitive-murein-endopeptidase
MRLLRHITLAAFVLAACAPAQDSPRPSAAAFANKAASSTVPAKQLFGAKRGPSAQRPAPLGSYAKGCVAGAAQLPETGPTWQAMRLSRNRNWGHPETIDFIQDLSRVAARQPGWQGLYVGDISQPRGGPMLSGHRSHQIGLDADIWMLPPDRLDLSREARENISSISLRRASGAYVNDNWSAQHHAILKAAASDPRVARIFVFPGAKVKMCDTETGDRSYLRKIRPWWGHHYHFHVRLNCPRGTRGCVEQDPPPRGDGCDDARQWVANILNPPPPKPVDPNAPKPKPRRDYTLSDLPQQCAAVLSSD
>NC_008044.1|WP_193339816.1|2797147_2798515_+|MFS-transporter
MQSIPLRKRIWGWWFFDWASQPYHTLLVTFVFGPFFAASATQYFIGTGLEGEAAKAAAQSSWSLCLTITGLIIGLSAPFLGALADIAGRKLPWIIGFSIAYVLGAAGLWFMDPAGSNLWWMLISFGVGFIGAEFALIFVNAQLPSLGSKDEVGALSGSGFAFGYLGGVVSLFIMLLLFVEQDSGKTLIGLDPILGLDASAREGTRAVGPFVAIWFVAFMIPYFAWVRDPRTPRRGTASLGRAVSMVVASVKGLKHRKSLTSYLVSSMLYRDALNGLYGFGGVYAGLVLDWSITQIGIFGIIAAISAALFSWAGGLADARFGPKPVIVLAILVLSLVCLIVVNMTRTEVFGVALAESSGLPDQIFFACGVLIGGFGGILQATSRTLMVRHTTPETATEAFGLYGLSGRATAFVAPALIGLMTTLTGSARLGITPVIALFALGLLLLLWVDGEGDQS
>NC_008044.1|WP_011539975.1|2796503_2797082_+|acyl-CoA-thioesterase
MYPIVRLLKDAALASRQPRLGPLETHVSRHHCWPWDLDIWLELNNGRTLTLYDLGRTMLTLRTGLAGVLKREGWAVAVAGASVRYRRRIKAMERFEMKSRAIGWDDRFIYVEQGMWKANGECANHALLRTVVTDKNGIVPPERVIKAWGQDIQSPDLPEWVKAWCAAEDLRPWPPMAESSADKGDVALASAS
>NC_008044.1|WP_044027283.1|2796081_2796369_-|YggT-family-protein
MMAIYGPLQLILSVVYFIMIVHIIMSWLINFQVLNLHQQFVAQIWYGINRLLEPIYTPLRRILPNTHPLDLAPLAALLIVISLRAYILPTLFGYM
>NC_008044.1|WP_011539973.1|2793913_2795953_-|DNA-helicase-RecQ
MHDAIPLLRDIFGFDDFRPGQEEIVEAVSAGENVLAIMPTGGGKSLCYQLPALRRAGITVVISPLIALMRDQVRALQEAGVCAGALTSGNTEEETEAVWNAIEAGELKLLYMAPERLAAGSAMGMLRRIGVSLIAVDEAHCVSQWGHDFRPDYLRIGELRRALDVPLAAFTATADQETQAEIVQKLFDGEAPRAFLRGFDRPNIHLAFAAKDSPRKQILEFADARRGQSGIVYCGTRAKTEDIARALEASGHVACHYHGGMEAEDRRIVETRFAREDGLIVVATVAFGMGIDKPDIRWVAHADLPKSIEAYYQEIGRAGRDGAPAETMTLFGPEDIRLRRNQIDEGLAPPERRGADHARLNALLGLAEAMSCRRQSLLSYFGENPEPCGHCDLCDTPVETFDGTTAVRKALSAILRTEETYGAGHLIDILIGNANDRVRQKGHDDLSVFACGREHSKPEWQAIFRQMMGRDLVRPDPERHGALRMTEPALPILRGEDSITLRKDTIKSATRRPAVKALVSDEDAPLLSALKAKRRALAEAQKVPAYVIFPDRTLIEMAENRPQSLDEMARISGVGAKKLERYGDAFLSVITGEAEALHPARRKLAGRAQGSIYDTLLEVQARLQRGECGTQKPLTCSASQLAKVAQMRSDDESGMERLLGERRAQRFASAFLEVLRGAG
>NC_008044.1|WP_011539972.1|2793056_2793812_-|YaaA-family-protein
MIILVSPAKKLNEERARGQATTVPRFLDQAAELAGVARTWSEDEIAKLMGISATLAKLNKDRFAAWSGDGQCAAGLMFDGDVYKELEPATFDDVTKDAAQRRLRILSGLYGLLRPTDAIEAYRLEMGRKTPGHPAGTLYGFWGDKIAAAIVEEARELGVGSVLNLASEEYAKAVPPKALGDLTLISPRFEEERGGSRKVIGVAAKRARGAMARWVLENGITEADDLKGFTVGGYAFDAETSAPQRPIFVRG
>NC_008044.1|WP_011539971.1|2792624_2793053_-|Lrp/AsnC-family-transcriptional-regulator
MDDLDRRIVAALQHNARESTTKLAAKLGVARTTVHERITRLEERGIIAGYTVVLRDPDEGNRVMVVVLLEVQQKETGRIIKRLEAYPEIRQCLSINGEYDLMVSAEAPRIEDLDILVDEVGRIPGVQRTNTLVVFGRRIDRV
>NC_008044.1|WP_011539970.1|2791375_2792497_-|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein
MQWNICVVGAGKIGQAIATFLKTSANYQVTLADHDLNALGAVAELGVPTRQIDAKDPVSLAKGLQGFDAVISAAPFFLTPMIAEAAKTAGAHYFDLTEDVAATEAVRKLAEGSETVFMPQSGLAPGFVGIAGASLAAEFDELDSLHMRVGALPKFPTNALKYNLTWSTDGLINEYCNPCDAIVNGARTKTAPLEDYERLSLDGVEYECFNTSGGLGTLPETLDGKARAVSYRSIRYPGHCDILKMLLHDLGLERRRDLMKEIFESALPRTDQDVVLVYCTARGRINGELREKSLINKSYARQIGGKTWSAIQVTTTAGVLGVVDLVRQGVLPARGFVSQEQVKLQDFLETEFGQLYRAGDIDHMTDTTKLAAE
>NC_008044.1|WP_011539980.1|2801737_2802157_+|aminoacyl-tRNA-hydrolase
MLRINDDITLQDWELTESFMRASGPGGQNVNKVSSAVELRFEAERSPHLPGPVKTRLRRIAGRRWTNDGALILQCDETRSQARNREIIRERLAELIRRALIKPKRRIATKPTRGSVERRLKAKKTRAEVKSLRGRVDGD
>NC_008044.1|WP_011539981.1|2802297_2803320_+|P1-family-peptidase
MKPGPRNLITDVTGLRVGNAADARLKSGTTVLTADQPFTAAVHVMGGAPGTRETDLLAPDKTVPAVDALVLSGGSAYGLDACSGVVDGLRAMGRGFRLGPAIVPICPGAIIFDLLNGGDKDWRDNPYPALGRAALRDASAEFALGTVGAGTGALTGMQKGGLGSASLVLENGLTVGALVVVNPIGSVTTPGERHFWAAPFEIDGEFGGLGPDPSAGIGRSLRSRKMEAMAELAGAAVSSEGSNTTIAIVATDAALTKAEATRMATTAHDGMARAILPSHGPHDGDLVFAAATGAQSMTDPAADMLALCHAGSLCLARAIARAVHAATPAEGDILPCWSDS
>NC_008044.1|WP_011539982.1|2803832_2804795_+|DMT-family-transporter
MSATVVQSNVLGILAAIGAAVAFSVIDVTFKFLSDGYPLYQVVFIRSVVALVLLLAVIIPLEGGVKILRTQNIRLHGLRVTAVVFANITFFSGLAVLPLAEAVAIAFATPLIVTLLSVLFLKERVGPWRWGAVMVGFSGILVIVKPGMAAFQPYALLPFLGSCGYATLHILTRRAGGSDKAATLSFYPTLGFLIVSALAGLVFGHGQWATGVPLWDVVLKPWAWPKGIEWVIFAVAGVSGAVGGYLVGQAYRLCEAGLVAPFEYVAMPLAVVWGVLVFAEWPEPSVWLGSALIIGAGLVSLWRETRTPGPPPRPRPRSSG
>NC_008044.1|WP_011539983.1|2804810_2805431_+|HAD-family-phosphatase
MPITAVVFDIGRVLIEWEPERFFDRLIGEPRRHALFQEVDLHGANLDVDRGYPFRETIYGLADKHPDWAAEIRHWHDSWIEMASPEIPHSVRLLRALKAKGVPVYALTNFGAETFVIAQTHYPFLREFDQAFVSAHLRCIKPDAEIYAHLEAGTGRRPDELLFTDDRPENVTAAAVRGWHTHLFDRPETWAARLVDEGLLTQEEAQ
>NC_008044.1|WP_011539984.1|2805427_2806345_+|ornithine-cyclodeaminase
MSLTQIGFDEGEALLEWVALTDALAEGHRRPKAEVGDTFLYRGKDTLLSRSAWIDGLGIAVKTAMIFPDNPTREVPMINGAVSLFDDATGQPEALVDFHLVTKWKTAGDSLLGARRLAHPNAKEILIVGAGTVAASLIEAFSAVWGDAQIRVWNRTIAKAEMLATAYPGVAVAPDLEQAVTAADIILTSTMSTDPVIQGAWLRPGQHLNMIGAYRPDMREADDLALSRARIYCDSFDTTLDHIGEFKIPLASGAMQRADVLADFYALDRFGRFDPEAITLFKNGGGAHLDLMTSRHVLDLWTQQT
>NC_008044.1|WP_011539985.1|2806341_2807274_+|alpha/beta-fold-hydrolase
MIWFLSAVLCLGALLFLPALQETLRRPLTESMRRNAPGKFAELSQGQTHYRWIGPLRGPVVVCVHGITTPSESFLPLAQELAEMGYRVLLYDLYGRGYSDYVPGLQDRAFLLQQLDDLLAYEGIVEDFVLVGHSAGGAIATAFAAANIWRVRSLILVTTVGLHKPRTPMAEFRKHAHGIQDLILRWSYPIVARRYVKGVFSDPRTPDAVRQAQQAQLSRRGYMPSNLAAIRGILRDDFAEEQKLFNRQGLPVLAIWARDDVIIPPQTSGRLAELNRSAKQEVVEDAGHEVVYTHAGDVARLIAENQRRGL
>NC_008044.1|WP_011539986.1|2807276_2808515_-|MFS-transporter
MDRSTPLFTPVLLVGCLIIMVSFAVRASFGVFQIPIADDFGWLRSEFSLAIAIQNLAWGIGQPIFGAIAEKIGDRKAIIIGAVVYAAGLVLSAGATTPFEMQAYEWLVGFGVAGTGFGVVLAVVGRASSDENRSMSLAIVTAAGSAGQIFGAPTAEYMLGLMSWQSVFLVFAGVVLALILSLPLMRAPVSAGKAELEESMGAILKKAFRDPSYTLIFLGFFSCGYQLAFVTAHFPAFVTEMCGPIMPGGVLHGMGITTTSALGAVSISLIGLANVAGTLLAGWAGKHYSKKYLLAGIYTARTIVAGAFILLPITPLSVILFSVAMGSLWLATVPLTSGLVAHIYGLRYMGTLYGIVFLSHQIGGFLGVWLGGRMYDIYGDYTMVWWIGVGVGAFSAIVHLPVRERPLQAAAA
>NC_008044.1|WP_044027285.1|2808674_2809748_+|cell-division-protein-ZapE
MTHMTDLYQARVDAGQIQPDPAQQAVLPEFDRIADGLRAEPVKRGLFRKAVRPEVKGLYLWGGVGRGKSMLMDLFVESLDDIPSRRVHFHAFMQEIHAKMHLAREAGTEDALAPVVADVVASVRLLAFDEMQITDITDAMIVGRLFEALFEAGVVVVTTSNRVPDDLYKNGLNRQLFLPFIDLIKDKMQVHEMVSPKDYRQDRLTGSRVYFTPLNAEVRAEMDAIWRDLTGGAAEPLVLMVKGREVTLPAYRNGVGRATFYDLCGTMLGPGDYLAVADAVKVLVLENIPALGRNNFNEAKRFVTLIDALYEARVRLICSAAAEPEFLYMEGDGAFEFERTASRLREMQDKDWGQPKA
>NC_008044.1|WP_011539988.1|2809875_2810637_+|DeoR/GlpR-transcriptional-regulator
MNATDLSERQRDILRLLEQSGFATIEDLAGRFGVTTQTIRRDVNDLRDRALLMRVHRGVRPHEGARPYASRAVEQQREKAALAREVLRLIPAGASVSIGLGSTPAEVARLLAHAGGRDVITNNLVAASHLWDAEDITLSICGGAVRDRSVSGSAAAEFFAAYRVDFAIFGVAGVDDDGALLDFRTEEARARAAMQTHARQSVLVLDQVKFQRRAPARGGWLHDPDYVVTNAPPPKALAAGLCAGALVLISEAP
>NC_008044.1|WP_011539989.1|2810633_2811905_-|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase
MTEQTSDAILARMMALHPKIIDLTLDRVWRLLAALENPQDKLPPVIHIAGTNGKGSTQAMIRAGLEGWGKSVHAYTSPHLARFHERIRLAGDLISEAHLTEVLDECYSANGDASITYFEITTVAGLLAFSRTPADYTLLEVGLGGRLDATNVITPEVSVITPVSIDHEQFLGNTLAKIAGEKAGIIKRGVPVVVGPQAEEAMEVIEDTAMRLGAPLIAYGQHWHVHEERGRLVYQDERGLLDLPLPNLMGAHQIQNAGAALAVLRHLGADEAACEAAVVGAQWPARMQRLKTGPLVEIAGAAELWLDGGHNAAAGIALADVLAKLPKRPTHLICGMLNTKDVTGYLRPLAAEAQSLTAVSIPGEAATLSAEETKAAASSVDLPATTAESVAEALTAILARDPDSRVLICGSLYLAGNILRENG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_008044_4	4.1\|2801672\|28\|NC_008044\|CRISPRCasFinder	2801672-2801699	28	NZ_CP018236	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed8	47943-47970	4	0.857
NC_008044_4	4.1\|2801672\|28\|NC_008044\|CRISPRCasFinder	2801672-2801699	28	NZ_CP018236	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed8	57437-57464	4	0.857
NC_008044_4	4.1\|2801672\|28\|NC_008044\|CRISPRCasFinder	2801672-2801699	28	MT770738	Rhizobium phage B1VFA, complete genome	76465-76492	6	0.786

1. spacer 4.1|2801672|28|NC_008044|CRISPRCasFinder matches to NZ_CP018236 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed8) position: , mismatch: 4, identity: 0.857

aatgccgcatgtctgaggtcgcaaaacc	CRISPR spacer
gatgccgcgtggctgaggtcgcaaaacg	Protospacer
.*******.** ***************

2. spacer 4.1|2801672|28|NC_008044|CRISPRCasFinder matches to NZ_CP018236 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed8) position: , mismatch: 4, identity: 0.857

aatgccgcatgtctgaggtcgcaaaacc	CRISPR spacer
gatgccgcgtggctgaggtcgcaaaacg	Protospacer
.*******.** ***************

3. spacer 4.1|2801672|28|NC_008044|CRISPRCasFinder matches to MT770738 (Rhizobium phage B1VFA, complete genome) position: , mismatch: 6, identity: 0.786

aatgccgcatgtctgaggtcgcaaaacc	CRISPR spacer
cctgcggcatgtctgcggtcgcaaagac	Protospacer
  *** ********* *********. *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

829193 : 838672

Pseudomonas_phage(20.0%)

integrase

attL 831563:831577|attR 843120:843134

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011538120.1\|829193_831602_+	endopeptidase La	A0A0R6PGP8	Moraxella_phage	8.5e-205	50.5
831563:831577	attL	NA	NA	NA	NA
WP_011538121.1\|832172_833177_-\|integrase	site-specific integrase	B3GVW7	Streptococcus_phage	4.6e-11	26.6
WP_166485533.1\|833334_833490_-	hypothetical protein	NA	NA	NA	NA
WP_044026687.1\|833486_833927_-	hypothetical protein	A0A1B0T6F9	Thiobacimonas_phage	3.9e-23	67.5
WP_011538123.1\|833923_834868_-	hypothetical protein	A0A2R2YB59	Pseudomonas_phage	7.1e-06	57.1
WP_011538124.1\|834864_835524_-	hypothetical protein	A0A291AUT5	Sinorhizobium_phage	4.0e-80	65.1
WP_011538125.1\|835669_836443_-	hypothetical protein	A0A2I7RMG9	Vibrio_phage	1.7e-05	28.2
WP_011538126.1\|836464_836770_-	DUF1364 domain-containing protein	A0A088F868	Sulfitobacter_phage	1.2e-28	59.4
WP_011538127.1\|836838_837342_-	hypothetical protein	A0A0U2C161	Paracoccus_phage	7.5e-55	65.0
WP_011538128.1\|837341_837950_-	YqaJ viral recombinase family protein	A0A0U2BXF3	Paracoccus_phage	3.8e-53	52.2
WP_011538129.1\|837949_838672_-	ERF family protein	K4NWX3	Pseudomonas_phage	9.2e-38	41.0
843120:843134	attR	NA	NA	NA	NA

DBSCAN-SWA_2

847786 : 858688

Pseudomonas_phage(36.36%)

capsid,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011538145.1\|847786_848365_+\|terminase	terminase small subunit	A0A0M3LS14	Mannheimia_phage	7.4e-22	61.2
WP_193339811.1\|848288_849593_+\|terminase	terminase	D2XJL9	Escherichia_phage	3.0e-140	61.5
WP_011538147.1\|849589_850969_+	DUF4055 domain-containing protein	A0A0H5AWC7	Pseudomonas_phage	2.9e-72	39.1
WP_011538148.1\|850955_852005_+\|capsid	minor capsid protein	A0A0H5BBX3	Pseudomonas_phage	2.2e-64	39.9
WP_011538149.1\|852234_852918_+	hypothetical protein	NA	NA	NA	NA
WP_011538150.1\|852930_853899_+	hypothetical protein	R9TJ64	Synechococcus_phage	1.4e-110	64.3
WP_011538151.1\|853962_854214_+	hypothetical protein	A0A0H5BBX8	Pseudomonas_phage	3.5e-05	77.4
WP_011538152.1\|854215_854683_+	hypothetical protein	W6B0V7	Acinetobacter_phage	6.4e-08	33.8
WP_011538153.1\|854679_855129_+	hypothetical protein	A0A2H4GY65	Pseudomonas_phage	2.1e-24	41.6
WP_011538154.1\|855125_855500_+	hypothetical protein	NA	NA	NA	NA
WP_011538155.1\|855499_855901_+	hypothetical protein	A0A1V0DY73	Dinoroseobacter_phage	3.2e-24	49.6
WP_011538156.1\|855897_856296_+	DUF4128 domain-containing protein	NA	NA	NA	NA
WP_044026695.1\|856292_856484_+	hypothetical protein	NA	NA	NA	NA
WP_011538157.1\|856571_857060_+	hypothetical protein	NA	NA	NA	NA
WP_011538158.1\|857162_857633_+	hypothetical protein	NA	NA	NA	NA
WP_011538159.1\|857758_858004_+	hypothetical protein	NA	NA	NA	NA
WP_011538160.1\|858000_858372_-	transcriptional regulator	A0A0P0ZCT8	Stx2-converting_phage	2.1e-17	42.6
WP_011538161.1\|858385_858688_-	type II toxin-antitoxin system HigB family toxin	F5A3A2	Riemerella_phage	1.2e-07	30.1

DBSCAN-SWA_3

1064390 : 1072047

uncultured_Mediterranean_phage(66.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011538335.1\|1064390_1065344_+	fatty acid desaturase	A0A1V0S9E0	Catovirus	7.4e-19	23.0
WP_011538336.1\|1065464_1066124_+	helix-hairpin-helix domain-containing protein	NA	NA	NA	NA
WP_011538337.1\|1066243_1067536_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	1.4e-84	50.2
WP_011538338.1\|1067791_1068076_+	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	1.8e-21	58.2
WP_011538339.1\|1068110_1069775_+	protein translocase subunit SecD	A0A1B1IVP7	uncultured_Mediterranean_phage	7.4e-06	23.4
WP_011538340.1\|1069778_1070747_+	protein translocase subunit SecF	A0A1B1IVP7	uncultured_Mediterranean_phage	7.2e-62	48.9
WP_011538341.1\|1070994_1071348_+	Mth938-like domain-containing protein	NA	NA	NA	NA
WP_011538342.1\|1071432_1072047_+	heme ABC exporter ATP-binding protein CcmA	M1I1A6	Acanthocystis_turfacea_Chlorella_virus	2.9e-08	32.9

DBSCAN-SWA_4

1136089 : 1150618

Paracoccus_phage(27.27%)

capsid,tail,protease,portal,head

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_193339806.1\|1136089_1137433_+	DNA-packaging protein	A0A1V0DY66	Dinoroseobacter_phage	5.1e-74	38.7
WP_011538398.1\|1137682_1138888_+\|portal	phage portal protein	W8ECU7	Geobacillus_phage	2.1e-58	36.4
WP_011538399.1\|1138880_1139105_+	hypothetical protein	NA	NA	NA	NA
WP_011538400.1\|1139139_1139712_+\|head,protease	HK97 family phage prohead protease	A0A0U2BX10	Paracoccus_phage	5.8e-27	45.9
WP_011538401.1\|1139732_1140929_+\|capsid	phage major capsid protein	B0VK33	Azospirillum_phage	1.4e-67	43.9
WP_011538402.1\|1141107_1141710_+	hypothetical protein	NA	NA	NA	NA
WP_011538403.1\|1141706_1142045_+\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_011538404.1\|1142041_1142449_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_011538405.1\|1142484_1142898_+\|tail	phage major tail protein, TP901-1 family	A0A1J0GVL1	Pseudoalteromonas_phage	1.4e-06	34.2
WP_011538406.1\|1142901_1143225_+	gene transfer agent family protein	NA	NA	NA	NA
WP_166485589.1\|1143236_1143437_+\|tail	phage tail assembly chaperone	NA	NA	NA	NA
WP_011538408.1\|1143440_1144100_+\|tail	phage tail tape measure protein	A0A1W6JP49	Morganella_phage	5.7e-10	29.9
WP_011538409.1\|1144113_1144746_+	DUF2460 domain-containing protein	A0A0K1Y6G4	Rhodobacter_phage	1.5e-47	46.4
WP_011538410.1\|1144745_1145624_+	DUF2163 domain-containing protein	A0A0B5A5B8	Paracoccus_phage	5.2e-59	43.2
WP_011538411.1\|1145620_1146058_+	C40 family peptidase	A0A1V0DYB6	Dinoroseobacter_phage	1.3e-31	47.7
WP_011538412.1\|1146070_1149991_+	glycoside hydrolase TIM-barrel-like domain-containing protein	A0A0B5A7K5	Paracoccus_phage	1.1e-228	39.4
WP_044027074.1\|1150014_1150299_+	hypothetical protein	NA	NA	NA	NA
WP_011538414.1\|1150411_1150618_-	cold-shock protein	Q9AZD3	Lactococcus_phage	1.1e-09	47.5

DBSCAN-SWA_5

1326778 : 1415831

Escherichia_phage(26.83%)

integrase,capsid,plate,terminase,tail,tRNA,portal

attL 1376499:1376555|attR 1415926:1415982

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_044027096.1\|1326778_1329430_+\|tRNA	alanine--tRNA ligase	A0A2K9L3D8	Tupanvirus	1.0e-81	39.1
WP_011538572.1\|1329436_1329724_+	DUF1330 domain-containing protein	NA	NA	NA	NA
WP_011538573.1\|1329843_1330620_+	class II glutamine amidotransferase	NA	NA	NA	NA
WP_011538574.1\|1330688_1332509_-	translational GTPase TypA	A0A1S5SF82	Streptococcus_phage	2.5e-23	44.7
WP_011538575.1\|1332635_1332965_-	multidrug transporter	NA	NA	NA	NA
WP_011538576.1\|1333105_1334272_-	HD domain-containing protein	NA	NA	NA	NA
WP_011538577.1\|1334268_1334517_-	hypothetical protein	NA	NA	NA	NA
WP_011538578.1\|1334516_1335170_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_011538579.1\|1335356_1335815_+	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_011538580.1\|1335881_1336925_+	cysteine desulfurase	A0A1X6WFP1	Pacmanvirus	1.6e-14	25.6
WP_011538581.1\|1336940_1338461_+	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
WP_011538582.1\|1338499_1338814_+	YbjQ family protein	NA	NA	NA	NA
WP_166485591.1\|1338886_1339591_+	FkbM family methyltransferase	M4QNU8	Ostreococcus_lucimarinus_virus	1.2e-05	30.1
WP_011538584.1\|1339653_1340409_+	Fe-S cluster assembly ATPase SufC	G3M9Y6	Bacillus_virus	7.7e-11	26.9
WP_011538585.1\|1340408_1341689_+	SufD family Fe-S cluster assembly protein	NA	NA	NA	NA
WP_011538586.1\|1341697_1342183_+	hypothetical protein	NA	NA	NA	NA
WP_011538587.1\|1342182_1342761_+	YIP1 family protein	NA	NA	NA	NA
WP_011538588.1\|1342753_1343974_+	cysteine desulfurase	Q2XUY6	environmental_halophage	9.3e-91	39.1
WP_011538589.1\|1344151_1344583_-	universal stress protein	NA	NA	NA	NA
WP_011538590.1\|1344582_1347180_-	TRAP transporter permease	NA	NA	NA	NA
WP_011538591.1\|1347285_1348257_-	TAXI family TRAP transporter solute-binding subunit	NA	NA	NA	NA
WP_011538592.1\|1348351_1349239_-	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_011538593.1\|1349386_1351786_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011538594.1\|1352243_1353467_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_044027097.1\|1353562_1354474_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_011538596.1\|1354553_1355243_-	phosphate regulon transcriptional regulator PhoB	W8CYM9	Bacillus_phage	1.4e-40	38.6
WP_011538597.1\|1355246_1355957_-	phosphate signaling complex protein PhoU	NA	NA	NA	NA
WP_011538598.1\|1355973_1356771_-	phosphate ABC transporter ATP-binding protein	NA	NA	NA	NA
WP_011538599.1\|1356783_1358151_-	phosphate ABC transporter permease PstA	NA	NA	NA	NA
WP_011538600.1\|1358150_1359629_-	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
WP_011538601.1\|1359738_1360779_-	substrate-binding domain-containing protein	A0A1B1IWY0	uncultured_Mediterranean_phage	2.2e-64	39.8
WP_011538602.1\|1361080_1362121_-	two-component sensor histidine kinase	W8CYF6	Bacillus_phage	8.0e-35	35.5
WP_044026731.1\|1362174_1363332_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	A0A2I2L687	Orpheovirus	4.0e-11	27.0
WP_011538604.1\|1363358_1363880_-	gamma carbonic anhydrase family protein	NA	NA	NA	NA
WP_011538605.1\|1363876_1364530_-	guanylate kinase	S4VT50	Pandoravirus	1.3e-11	51.2
WP_011538606.1\|1364545_1365442_-	YicC family protein	NA	NA	NA	NA
WP_011538607.1\|1365683_1366631_+	PAS domain-containing protein	NA	NA	NA	NA
WP_011538608.1\|1366860_1368231_-	3-deoxy-7-phosphoheptulonate synthase class II	NA	NA	NA	NA
WP_011538609.1\|1368431_1369436_+	GlxA family transcriptional regulator	NA	NA	NA	NA
WP_011538610.1\|1369442_1370549_-	PQQ-dependent sugar dehydrogenase	NA	NA	NA	NA
WP_011538611.1\|1370688_1371888_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_011538612.1\|1371994_1372786_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.0e-10	22.6
WP_011538613.1\|1372782_1373496_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	8.3e-15	24.8
WP_011538614.1\|1373499_1374510_+	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_011538615.1\|1374506_1375832_+	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_166485592.1\|1375913_1376240_-	hypothetical protein	NA	NA	NA	NA
1376499:1376555	attL	NA	NA	NA	NA
WP_044026732.1\|1376647_1377655_-	late control protein D	A0A088FRU7	Escherichia_phage	1.1e-70	42.6
WP_166485543.1\|1377645_1377915_-\|tail	tail protein X	A0A1B2LRT9	Wolbachia_phage	2.1e-11	47.1
WP_011538619.1\|1377835_1378246_-\|tail	phage tail protein	A0A1W6JT48	Escherichia_phage	1.1e-27	46.3
WP_011538620.1\|1378245_1380720_-\|tail	phage tail tape measure protein	A0A0U2BXT9	Paracoccus_phage	3.3e-26	27.6
WP_011538621.1\|1380843_1381143_-\|tail	phage tail assembly protein	NA	NA	NA	NA
WP_011538622.1\|1381152_1381659_-\|tail	phage major tail tube protein	A0A088FRU2	Escherichia_phage	3.2e-45	51.8
WP_011538623.1\|1381658_1382876_-\|tail	phage tail sheath subtilisin-like domain-containing protein	A0A088FVH5	Escherichia_phage	2.9e-145	58.5
WP_011538624.1\|1382989_1383349_-	DUF1353 domain-containing protein	NA	NA	NA	NA
WP_011538625.1\|1383349_1383850_-	hypothetical protein	NA	NA	NA	NA
WP_011538626.1\|1383851_1384859_-	hypothetical protein	NA	NA	NA	NA
WP_049763235.1\|1384858_1385179_-	hypothetical protein	K4I1G2	Acidithiobacillus_phage	2.0e-08	38.1
WP_011538628.1\|1385180_1385909_-\|tail	phage tail protein	A0A193GYM0	Enterobacter_phage	2.9e-39	46.2
WP_044026733.1\|1385919_1386453_-\|tail	phage tail protein I	A0A193GYD1	Enterobacter_phage	2.9e-28	37.4
WP_011538630.1\|1386445_1387345_-\|plate	baseplate J/gp47 family protein	D5LGZ3	Escherichia_phage	8.1e-84	55.1
WP_011538631.1\|1387344_1387683_-	GPW/gp25 family protein	A0A088FV58	Escherichia_phage	1.9e-30	57.8
WP_011538632.1\|1387731_1388022_-	PAAR domain-containing protein	K4ICQ1	Acidithiobacillus_phage	1.8e-24	60.0
WP_011538633.1\|1388021_1388399_-\|plate	phage baseplate assembly protein V	NA	NA	NA	NA
WP_011538634.1\|1388395_1388932_-	hypothetical protein	A0A1W6JT55	Escherichia_phage	1.2e-34	45.6
WP_011538635.1\|1388931_1389480_-	hypothetical protein	A0A193GYC6	Enterobacter_phage	1.7e-36	47.8
WP_011538636.1\|1389484_1389796_-	hypothetical protein	A0A193GYM3	Enterobacter_phage	6.1e-23	49.1
WP_011538637.1\|1389795_1390053_-	hypothetical protein	NA	NA	NA	NA
WP_084789042.1\|1390119_1392057_-\|capsid	phage major capsid protein	A0A088FRT0	Escherichia_phage	1.6e-169	51.0
WP_044027107.1\|1392127_1393675_-\|portal	phage portal protein	A0A1W6JT60	Escherichia_phage	3.1e-139	54.0
WP_044026734.1\|1393737_1394265_-	hypothetical protein	A0A1W6JT65	Escherichia_phage	1.9e-37	47.4
WP_011538641.1\|1394278_1396231_-\|terminase	phage terminase large subunit family protein	A0A088FQV3	Escherichia_phage	5.1e-224	60.6
WP_011538642.1\|1396227_1396782_-\|terminase	terminase small subunit	A0A193GYK5	Enterobacter_phage	7.3e-35	50.6
WP_011538643.1\|1396954_1397338_-	bacteriophage spanin2 family protein	I6R9K4	Celeribacter_phage	5.4e-05	36.6
WP_049763236.1\|1397337_1398066_-	lysozyme	A0A0A8KXN5	Burkholderia_phage	1.4e-25	46.3
WP_011538645.1\|1398108_1398345_-	hypothetical protein	NA	NA	NA	NA
WP_011538646.1\|1398592_1399195_+	hypothetical protein	NA	NA	NA	NA
WP_011538647.1\|1399239_1399593_+	DUF2513 domain-containing protein	NA	NA	NA	NA
WP_011538648.1\|1399674_1400223_-	hypothetical protein	NA	NA	NA	NA
WP_011538649.1\|1400405_1400966_-	hypothetical protein	NA	NA	NA	NA
WP_166485544.1\|1400969_1401383_-	DUF1064 domain-containing protein	A0A0U2C0S3	Paracoccus_phage	6.4e-20	55.6
WP_011538651.1\|1401379_1401808_-	hypothetical protein	A0A1X9HXA5	Ruegeria_phage	1.9e-38	63.6
WP_084789017.1\|1401813_1402398_-	DUF2312 domain-containing protein	A0A1X9HX62	Ruegeria_phage	4.5e-35	47.1
WP_011538653.1\|1402390_1402690_-	hypothetical protein	NA	NA	NA	NA
WP_011538654.1\|1402686_1403685_-	helix-turn-helix domain-containing protein	A0A2H4JAS0	uncultured_Caudovirales_phage	8.9e-07	31.4
WP_011538655.1\|1403887_1404421_-	class I SAM-dependent methyltransferase	A0A218MLE3	uncultured_virus	3.2e-40	46.1
WP_044026736.1\|1404697_1404880_-	hypothetical protein	NA	NA	NA	NA
WP_011538658.1\|1405183_1405507_-	hypothetical protein	NA	NA	NA	NA
WP_044026737.1\|1405503_1405716_-	hypothetical protein	NA	NA	NA	NA
WP_011538659.1\|1405802_1406438_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011538660.1\|1406798_1407716_-	hypothetical protein	NA	NA	NA	NA
WP_011538661.1\|1407722_1408715_-	ankyrin repeat domain-containing protein	NA	NA	NA	NA
WP_011538662.1\|1409153_1409492_-	hypothetical protein	NA	NA	NA	NA
WP_044026739.1\|1409889_1412286_-	SIR2 family protein	NA	NA	NA	NA
WP_011538664.1\|1412749_1413019_+	hypothetical protein	NA	NA	NA	NA
WP_044026740.1\|1413247_1413550_+	hypothetical protein	NA	NA	NA	NA
WP_011538666.1\|1413692_1414379_+	hypothetical protein	A0A0U2BXK1	Paracoccus_phage	8.3e-97	72.7
WP_044026741.1\|1414406_1414586_+	hypothetical protein	NA	NA	NA	NA
WP_044026742.1\|1414632_1414836_+	hypothetical protein	NA	NA	NA	NA
WP_011538667.1\|1414829_1415831_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
1415926:1415982	attR	NA	NA	NA	NA

DBSCAN-SWA_6

1714469 : 1738018

Rhodobacter_phage(50.0%)

capsid,terminase,tail,portal,head

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011538936.1\|1714469_1714868_-	hypothetical protein	A0A1X9HVL7	Ruegeria_phage	7.6e-34	56.5
WP_011538937.1\|1714864_1715674_-	glycoside hydrolase family 108 protein	A0A1V0DY74	Dinoroseobacter_phage	4.0e-66	52.5
WP_011538938.1\|1715675_1716110_-	hypothetical protein	NA	NA	NA	NA
WP_011538169.1\|1716106_1716403_-	hypothetical protein	NA	NA	NA	NA
WP_011538939.1\|1716409_1716757_-	DUF1353 domain-containing protein	NA	NA	NA	NA
WP_011538940.1\|1716734_1717235_-	DUF4376 domain-containing protein	A0A1B1P734	Rhodovulum_phage	1.5e-18	45.9
WP_049763241.1\|1717215_1717500_-	hypothetical protein	NA	NA	NA	NA
WP_011538942.1\|1718304_1719249_-	hypothetical protein	A0A2I7RB26	Vibrio_phage	2.8e-10	24.4
WP_011538943.1\|1719248_1723772_-\|tail	tail tape measure protein	G8DH54	Emiliania_huxleyi_virus	2.7e-10	78.3
WP_011538944.1\|1724206_1724542_-	hypothetical protein	NA	NA	NA	NA
WP_011538945.1\|1724640_1725090_-	hypothetical protein	NA	NA	NA	NA
WP_011538946.1\|1725188_1725638_-	hypothetical protein	M4QQ74	Salicola_phage	9.5e-17	37.6
WP_011538947.1\|1725698_1725983_-	hypothetical protein	NA	NA	NA	NA
WP_166485595.1\|1726024_1726330_-	hypothetical protein	NA	NA	NA	NA
WP_011538949.1\|1726377_1726833_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_044026766.1\|1726845_1727238_-\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_011538951.1\|1727251_1727833_-\|head,tail	phage head-tail connector protein	I3UM02	Rhodobacter_phage	8.7e-39	47.6
WP_011538952.1\|1727836_1728298_-	hypothetical protein	NA	NA	NA	NA
WP_011538953.1\|1728294_1728756_-	hypothetical protein	I3UM00	Rhodobacter_phage	3.8e-45	64.7
WP_011538954.1\|1728819_1730139_-\|capsid	phage major capsid protein	I3ULZ9	Rhodobacter_phage	1.2e-184	77.0
WP_011538955.1\|1730141_1731089_-	S49 family peptidase	I3ULZ8	Rhodobacter_phage	2.0e-109	68.3
WP_011538956.1\|1731085_1732372_-\|portal	phage portal protein	I3ULZ7	Rhodobacter_phage	3.0e-156	63.7
WP_011538957.1\|1732374_1734075_-\|terminase	terminase large subunit	I3ULZ6	Rhodobacter_phage	1.5e-134	46.1
WP_011538958.1\|1734085_1734631_-	hypothetical protein	NA	NA	NA	NA
WP_044026769.1\|1734671_1735037_-	HNH endonuclease	I3ULZ4	Rhodobacter_phage	9.7e-28	61.1
WP_166485547.1\|1735225_1735813_-	hypothetical protein	NA	NA	NA	NA
WP_011538961.1\|1736143_1738018_-	hypothetical protein	G8EY43	Synechococcus_phage	3.1e-29	25.0

DBSCAN-SWA_7

1752566 : 1773068

Paracoccus_phage(25.0%)

capsid,terminase,tail,protease,portal,head

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011538981.1\|1752566_1752965_-	hypothetical protein	A0A1X9HVL7	Ruegeria_phage	1.7e-33	55.8
WP_011538982.1\|1752961_1753771_-	glycoside hydrolase family 108 protein	A0A1V0DY74	Dinoroseobacter_phage	9.9e-65	51.3
WP_011538983.1\|1753772_1754207_-	hypothetical protein	NA	NA	NA	NA
WP_011538169.1\|1754203_1754500_-	hypothetical protein	NA	NA	NA	NA
WP_011538939.1\|1754506_1754854_-	DUF1353 domain-containing protein	NA	NA	NA	NA
WP_011538985.1\|1754831_1755464_-	DUF4376 domain-containing protein	A0A1B1P734	Rhodovulum_phage	1.9e-18	45.5
WP_044026777.1\|1755460_1756978_-	hypothetical protein	A0A0F7LB88	uncultured_marine_virus	9.5e-53	44.3
WP_011538987.1\|1756974_1757919_-	hypothetical protein	A0A2I7RB26	Vibrio_phage	3.3e-11	24.4
WP_011538988.1\|1757915_1762442_-\|tail	tail tape measure protein	G8DH54	Emiliania_huxleyi_virus	7.9e-10	46.5
WP_011538989.1\|1762470_1762809_+	hypothetical protein	NA	NA	NA	NA
WP_044026780.1\|1762849_1763800_-	hypothetical protein	NA	NA	NA	NA
WP_011538991.1\|1763993_1764332_-	hypothetical protein	NA	NA	NA	NA
WP_011538945.1\|1764430_1764880_-	hypothetical protein	NA	NA	NA	NA
WP_011538946.1\|1764978_1765428_-	hypothetical protein	M4QQ74	Salicola_phage	9.5e-17	37.6
WP_011538947.1\|1765488_1765773_-	hypothetical protein	NA	NA	NA	NA
WP_044026782.1\|1765814_1766168_-	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_011538993.1\|1766167_1766623_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_011538994.1\|1766619_1766958_-\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_011538995.1\|1766957_1767530_-\|head,tail	phage head-tail connector protein	A0A141GEW4	Brucella_phage	5.4e-33	44.7
WP_044026783.1\|1767526_1767709_-	hypothetical protein	NA	NA	NA	NA
WP_011538996.1\|1767771_1768983_-\|capsid	phage major capsid protein	A0A0U2C0U7	Paracoccus_phage	5.5e-136	66.1
WP_044027158.1\|1769007_1769685_-\|head,protease	HK97 family phage prohead protease	A0A0U2BX10	Paracoccus_phage	6.4e-49	57.6
WP_011538998.1\|1769677_1770901_-\|portal	phage portal protein	A0A0U2BXP2	Paracoccus_phage	2.7e-130	60.8
WP_011538999.1\|1770901_1772683_-\|terminase	terminase	B0VK29	Azospirillum_phage	7.4e-121	41.1
WP_011539000.1\|1772660_1773068_-\|terminase	P27 family phage terminase small subunit	NA	NA	NA	NA

DBSCAN-SWA_8

3188662 : 3198017

Cedratvirus(14.29%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011540331.1\|3188662_3190258_+	phosphoglycerate dehydrogenase	A0A2R8FCS0	Cedratvirus	3.1e-46	38.6
WP_011540332.1\|3190436_3191171_+	serine/threonine protein phosphatase	A0A1V0EF12	Caulobacter_phage	2.3e-28	36.5
WP_044027312.1\|3191377_3192409_-	L-threonine 3-dehydrogenase	R9TPW0	Vibrio_phage	5.9e-14	64.7
WP_011540334.1\|3192425_3193610_-	glycine C-acetyltransferase	G9E4Q1	Emiliania_huxleyi_virus	6.3e-36	29.1
WP_011540335.1\|3193774_3194341_-	helix-turn-helix transcriptional regulator	I3VYZ1	Thermoanaerobacterium_phage	1.6e-05	43.3
WP_011540336.1\|3194449_3195625_+	acetyl-CoA C-acyltransferase family protein	NA	NA	NA	NA
WP_011540337.1\|3195734_3197261_-	2-polyprenylphenol 6-hydroxylase	A0A2P0VMP1	Tetraselmis_virus	1.3e-20	32.0
WP_011540338.1\|3197264_3198017_-	bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE	A0A097BYE1	Leuconostoc_phage	2.7e-08	26.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_008043

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_008044

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection