CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_008529	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, complete sequence	3 crisprs	Cas14u_CAS-V,DEDDh,cas3,cas8e,cse2gr11,cas7,cas5,cas6e,cas1,DinG,cas14j	2	8	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_008529_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008529_1

270948-271042

Orphan

Consensus_repeat	Method
AGGCCAGCTCTAAGTCGGCGGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008529_1

>merge|NC_008529|1|270948-271042|CRISPRCasFinder
AGGCCAGCTCTAAGTCGGCGGCTAAATCCGCGGCCAGTTCTGCCGTTAGTTCGACAAAATCCTCCTCAAGCCAGGCCAGCTCTAAGTCCGCGGCT

>NC_008529|1|1|270948-271042|CRISPRCasFinder
AGGCCAGCTCTAAGTCGGCGGCT	AAATCCGCGGCCAGTTCTGCCGTTAGTTCGACAAAATCCTCCTCAAGCC
AGGCCAGCTCTAAGTCCGCGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008529.1\|WP_011677992.1\|259905_260871_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225420
NC_008529.1\|WP_003620715.1\|271667_271934_-\|DUF1294-domain-containing-protein	unknown	unknown	gnl\|CDD\|377743
NC_008529.1\|WP_003619401.1\|266697_267174_+\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|376605
NC_008529.1\|WP_011677990.1\|257705_258470_+\|nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|350158
NC_008529.1\|WP_011677999.1\|272029_272806_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NC_008529.1\|WP_011678005.1\|278259_278928_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_008529.1\|WP_011678004.1\|276657_277995_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_008529.1\|WP_011677997.1\|267253_268687_-\|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236426
NC_008529.1\|WP_003619413.1\|262360_263293_+\|homocysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|181899
NC_008529.1\|WP_011543614.1\|276109_276355_+\|arginine-deiminase	unknown	unknown	gnl\|CDD\|153390
NC_008529.1\|WP_041813190.1\|273854_274475_-\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|224423
NC_008529.1\|WP_011543615.1\|276376_276661_+\|hypothetical-protein	unknown	unknown	unknown
NC_008529.1\|WP_003620710.1\|269994_270549_-\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|238245
NC_008529.1\|WP_003622413.1\|274476_275277_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|130314
NC_008529.1\|WP_011677996.1\|264742_265750_+\|asparaginase	unknown	unknown	gnl\|CDD\|199207
NC_008529.1\|WP_011677995.1\|264296_264746_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_008529.1\|WP_003622358.1\|264034_264238_+\|chorismate-mutase	unknown	unknown	gnl\|CDD\|376623
NC_008529.1\|WP_011678003.1\|275273_275984_-\|metal-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224046
NC_008529.1\|WP_011677991.1\|258549_259812_-\|carboxylate--amine-ligase	unknown	unknown	gnl\|CDD\|226433
NC_008529.1\|WP_011678001.1\|273469_273721_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215122

Protein	Function_ID	Function_description	E-value
NC_008529.1\|WP_011677992.1\|259905_260871_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	6.23872e-50
NC_008529.1\|WP_003620715.1\|271667_271934_-\|DUF1294-domain-containing-protein	gnl\|CDD\|377743	pfam06961, DUF1294, Protein of unknown function (DUF1294). This family includes a number of hypothetical bacterial and archaeal proteins of unknown function.	8.13263e-19
NC_008529.1\|WP_003619401.1\|266697_267174_+\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	9.93276e-48
NC_008529.1\|WP_011677990.1\|257705_258470_+\|nucleoside-phosphorylase	gnl\|CDD\|350158	cd09007, NP-I_spr0068, uncharacterized subfamily of the nucleoside phosphorylase-I family. This subfamily is composed of uncharacterized members including Streptococcus pneumoniae hypothetical protein spr0068. The nucleoside phosphorylase-I (NP-I) family members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases such as purine nucleoside phosphorylase (PNP, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases such as AMP nucleosidase (AMN, EC 3.2.2.4) and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). Members of the NP-I family display different physiologically relevant quaternary structures: hexameric (trimer-of-dimers arrangement of Shewanella oneidensis MR-1 UP); homotrimeric (human PNP and Escherichia coli PNPII or XapA); hexameric (with some evidence for co-existence of a trimeric form) such as E. coli PNPI (DeoD); or homodimeric such as human and Trypanosoma brucei UP. The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	1.97707e-98
NC_008529.1\|WP_011677999.1\|272029_272806_-\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	1.22264e-17
NC_008529.1\|WP_011678005.1\|278259_278928_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	4.8716e-07
NC_008529.1\|WP_011678004.1\|276657_277995_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.61298e-17
NC_008529.1\|WP_011677997.1\|267253_268687_-\|nicotinate-phosphoribosyltransferase	gnl\|CDD\|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NC_008529.1\|WP_003619413.1\|262360_263293_+\|homocysteine-S-methyltransferase	gnl\|CDD\|181899	PRK09485, mmuM, homocysteine methyltransferase; Provisional.	2.68896e-159
NC_008529.1\|WP_011543614.1\|276109_276355_+\|arginine-deiminase	gnl\|CDD\|153390	cd07321, Extradiol_Dioxygenase_3A_like, Subunit A of Class III extradiol dioxygenases. Extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into substrates using a variety of reaction mechanisms, resulting in the cleavage of aromatic rings. There are two major groups of dioxygenases according to the cleavage site of the aromatic ring. Intradiol enzymes cleave the aromatic ring between two hydroxyl groups, whereas extradiol enzymes cleave the aromatic ring between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Extradiol dioxygenases can be divided into three classes. Class I and II enzymes are evolutionary related and show sequence similarity, with the two domain class II enzymes evolving from the class I enzyme through gene duplication. Class III enzymes are different in sequence and structure and usually have two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. This model represents subunit A of class III extradiol dioxygenase enzymes. The A subunit is the smaller, non-catalytic subunit. Enzymes that belong to this family include Protocatechuate 4,5-dioxygenase (LigAB) A subunit, 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase (CarB) A subunit, Gallate Dioxygenase and proteins of unknown function.	5.26805e-25
NC_008529.1\|WP_041813190.1\|273854_274475_-\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	4.30375e-07
NC_008529.1\|WP_003620710.1\|269994_270549_-\|cysteine-hydrolase	gnl\|CDD\|238245	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.	1.3816e-45
NC_008529.1\|WP_003622413.1\|274476_275277_-\|ABC-transporter-permease	gnl\|CDD\|130314	TIGR01247, drrB, daunorubicin resistance ABC transporter membrane protein. This model describes daunorubicin resistance ABC transporter, membrane associated protein in bacteria and archaea. The protein associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	6.9213e-07
NC_008529.1\|WP_011677996.1\|264742_265750_+\|asparaginase	gnl\|CDD\|199207	cd08963, L-asparaginase_I, Type I (cytosolic) bacterial L-asparaginase. Asparaginases (amidohydrolases, E.C. 3.5.1.1) are enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases. This model represents type I L-asparaginases, which are highly specific for asparagine and localized in the cytosol. Type I L-asparaginase acts as a dimer. A conserved threonine residue is thought to supply the nucleophile hydroxy-group that attacks the amide bond. Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of them are annotated as asparaginase/glutaminase. One example of an enzyme with no L-glutaminase activity is the type I L-asparaginase from Wolinella succinogenes.	3.12063e-138
NC_008529.1\|WP_011677995.1\|264296_264746_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.28605e-14
NC_008529.1\|WP_003622358.1\|264034_264238_+\|chorismate-mutase	gnl\|CDD\|376623	pfam01817, CM_2, Chorismate mutase type II. Chorismate mutase EC:5.4.99.5 catalyzes the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine.	6.35789e-14
NC_008529.1\|WP_011678003.1\|275273_275984_-\|metal-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	1.03643e-58
NC_008529.1\|WP_011677991.1\|258549_259812_-\|carboxylate--amine-ligase	gnl\|CDD\|226433	COG3919, COG3919, Predicted ATP-grasp enzyme [General function prediction only].	2.59458e-103
NC_008529.1\|WP_011678001.1\|273469_273721_+\|hypothetical-protein	gnl\|CDD\|215122	PLN02190, PLN02190, cellulose synthase-like protein.	0.00373029

>NC_008529.1|WP_003620710.1|269994_270549_-|cysteine-hydrolase
MKNEALLIIDYTNDFVDDKGALTCGAPAQALAGQIVSLADQFLAAGKWVILPTDKHFKGNPYHPETKLFPPHNLPNTWGREFYGPLQTWYNKHQDDEHVLVLDKSRYSAFCATGLDLFLRERKVSRVHLAGVCTDICVLHTAMDAYNHGYDITVHEKAVAALNDAGQEWALNHFKSCLGAEVVD
>NC_008529.1|WP_011677997.1|267253_268687_-|nicotinate-phosphoribosyltransferase
MSLSHALITDLYEFSMANGYFETLPRDTEAVFDVFYRTVPDNGSFVVSAGLEQVVEQLRGFHYTKEDIDYLKSLKLFSAEFISYLETMTFDCVVYAIPEGTPVFPRVPILTVKGPLIQCQLLETFVLNLINHQSLIATKSRRINLAAAGRPVMEFGARRAQGPDASVLGARAAVIGGCGSTSNVLSAAKYNIPVAGTMAHAWVQSYPTELEAFEKWAEIYPDNALLLVDTYDVLTSGVPNAIKVFKELRAKGHKKFGIRIDSGDIAKLSRKARKMMDDAGFPEATITASNALNENVIDSLLQEGAPLDSFGVGEQLITSSSSPVLSGVFKLAALKIGDGEWQPKIKLSNSKEKVTLPGEKKAYRLYHKGTKNAFADVIALADESLPEEFVGINMDPMMTETEANLKDFDAVLLTQVVVGPKAKSIETDTFKIQKHMYEKLAELPEETQRLLNPDRYPVYLTPALADLQAKMIKDHKL
>NC_008529.1|WP_003619401.1|266697_267174_+|large-conductance-mechanosensitive-channel-protein-MscL
MPKRINLPDGQQAVESTKGFFGEFKAFISKGNVMDMAVGIIIGGAFTTIVKSLVSDIISPLLGLVGGMNFDQFSLKFAGVTLAYGKFLTAVINFLMMAFVLFFIVKAFNRAGSLIKKEEEVEEEATTKVCPYCKSEIDIEASRCPMCTSQLEEKMAEQ
>NC_008529.1|WP_011677996.1|264742_265750_+|asparaginase
MTNKKILLLSTGGTIASVASEEGLIPGQSGAELLHTLGGLPYEVEVKDILSLDSSNIQPEEWAFIAEQIYKLRRGFDGIVVSHGTDTMAYTASMLTFMLQGIDLPVVLTGSQVPMQAILSDAPDNLRVAFAAAATCKPGIYIAFNRQIMRGCRCVKIRTTGFDAFKSINVDPVAMVTSDGIDIKHKDFEYVPSEHAICTLNTKVEPQVAMIKLFPGFDPAVLSAMVDSGVKGIVIEAYGLGGMNYMRRNMVKAIGEIIKRGVPVVACSQCLYERTDLTKYEVGRAAMLEGAISGRDMTSESAVTKLMWALGQGMDLEDVRAFFNKDIAGEVTITD
>NC_008529.1|WP_011677995.1|264296_264746_+|MarR-family-transcriptional-regulator
MMDLGLRVKKINDLMAKRGNYELKKLGLTFSQFHCLVYLEKCAGQQAPLKQLEKHFEVAQTTMAGIVGRLEGKGYVRSHLAESDKRVKIVCLTDEGRQICASAKKGMHKLQEKVEQLYSRQELSHLEKYLDRLYELLAEENREACEEKR
>NC_008529.1|WP_003622358.1|264034_264238_+|chorismate-mutase
MADLSKLREQIDQADQDLVKALVKRYDLVMEVGRVKREKGQAVFDPKREERVLDKVTNLAQRPEEDF
>NC_008529.1|WP_003619413.1|262360_263293_+|homocysteine-S-methyltransferase
MADLPTLLAQGPVTLDGSMSTPLEAWGEDTNSDLWTAKALADNPDLVYRVHQEYFKAGARVTITDSYQASLPAFMKHGLSEDAARALIRESAAVAIKARDDFEKATGIHNFVAGSVGPYGAYLADGSEYRGDYALSHEEYVDFHAPRIEELVAGGVDCLAVETQPKLSEVRAILDYLKAKYPDLPVYVSFSLKDPATISEGLPLTEAVEEVSAYAQVFAAGANCFKLAWTVDVVKNLRASKLPIVVYPNSGAEYDPSVKKWVYPPEAADFGQAGAAWLAAGAKLVGGCCTTMPEDIAGLAAAVKKVYTAF
>NC_008529.1|WP_011677992.1|259905_260871_-|Crp/Fnr-family-transcriptional-regulator
MLTPNDSSSFENQLSPRQDLTFNSLQALFDQQGLPFSPPSSQFGILQFSNFDLLVSDQCPYTIKCAFFKGTDQDEFLDRQEFTGSLAAQFQQVYAFLEKHNPVESQIKGLYREDRPAYPKQALREALMNAIIHRDYSNPASSLINLYTDRVEFISFGGLMPGITLEDIQLGLSVCRNKRLADLFYQLKLVESYGTGLARIKSAYKGSRLAPQILAAPSSFKVLLPHYQAAVKATSKPVKKAVTPAPSPSPAPKPKARATGNEETVLAFGKEHGEFIRSDIEELLGVSPATATRLLRQMENSGLVLKRGKAKAIRYRISENS
>NC_008529.1|WP_011677991.1|258549_259812_-|carboxylate--amine-ligase
MQQFTPILLGSDINVYGMARSFHEAYGIKVQAWGASTLAPTRYSKIVDIEVHPGFTEDPEFIKVMREKIKEYKKHPEPVILISCGDGYSELLAKHKQELEEAFIVPYIDYALLEKLISKEGFYEVCEEYGLPYPKTKIITMSAYKDGSYADVPFPFPVALKPEDPVSWLDVQFEGRKKAFVIKDLDEFKDIVGKIYTNGYKEDLILQDFIPGDDSNMRVLNAYVDKNHQVKMMCLGHPLLEDPDPIAIGNYMVIAPDYDEKLYQTVQAFLEKINYTGMANFDIKYDVRDGQYKFFEINLRQGRSSFYVTLNGYNLAKWYVDDYVEDSLKDQPVVYGNQDPAKHKLWLGVPDKIFEQYAVDSLAKKEALALLRAGKVGTTVFYKPDMNVKRWLLMKHMYHNYYKDYQKYFKVNKEQYFEKK
>NC_008529.1|WP_011677990.1|257705_258470_+|nucleoside-phosphorylase
MIEKNELPILEYDPVSWEVLKPGHDNEGVRLPEKCLFAFLGDEVDKYAEQVKATVADHFITIDRLRPIYIIENQGEQLCLCRAPLGGPAAAQFMDALIALGCRKFLAVGSCGTLVDIKENDFLIPARALRDEGTSYKYLPASRYVDLDPAAVEKIGQGLKEQGLPFEPYTTWTTDGFFRETQDMVEYRRGEGCQVVEMECASMAAVAAKRGAEFGQLLYTADSLANVEAHDDRDWGQTSQAKALHICLRIIHNF
>NC_008529.1|WP_003620715.1|271667_271934_-|DUF1294-domain-containing-protein
MNNFWQSSLLLINLIAFALYGIDKAKARMHAWRIPERLLLTCGLLAPVGSGLGMLAFHHKVRKAYFYLAIFAGFILWAAIDYLILSFS
>NC_008529.1|WP_011677999.1|272029_272806_-|NUDIX-hydrolase
MPELEKIVERPLITITNLIWSFNKETHRVQLLLVKRKDEPFADRWALPETLLLLRENESADQAAVRLIKEKIGLDLPETSTEQLATFTSPHRTPGERALALTYMTYLPAMPNLRPGYEASDVAWFAFENFGHKYELFSADKDLTFELAENSHALAFDHDEIIAVAIQRIRNKLDYQPSILQILGPEFTLREAREVYAPFFQTTVDEIDNSNFRKTHGSLFTELGVQKNYHKSGRPPKLYCLKETQSNILWRKANNKQG
>NC_008529.1|WP_011678001.1|273469_273721_+|hypothetical-protein
MYQASRLPFWERVFLVVGNSVIFWLWHHLLIVALGLLTLLGLVIYLVVSGIRQKNVAKAVWLVVIFCSCLGLVYFAMSCAIMD
>NC_008529.1|WP_041813190.1|273854_274475_-|prolyl-oligopeptidase-family-serine-peptidase
MHKIVEYIFCRDCKKVYFYLHGGPLFTLRNWQEDPFATMLYNEQRNFILLNYPIVYGNGGISDYQFLKEYFWEYKRQNPNTEMVLLGESYGGYLASLFAAEYIFRKIIAISAFTSIAYQELFSSERSWLKDYLSENALDFYTLCRDNKVNTRTIFINGSRDSRVPYQQFLALPFIKKFKVNILPGFTHRESGTRLEYVVSLIKQEL
>NC_008529.1|WP_003622413.1|274476_275277_-|ABC-transporter-permease
MNPQHFRNISLGLRSIRIVANNEWRAFVHNKGLLLSMFMQPLITYGLLVMALNQNLASVHYESLILPYKQYALTGVLSFFMTTQMSQAMYRATVDKEYGLLAIKFTNGVQPWHYLTGMSFFPIAGLLFQSAVLIVLGLATGGVYNLGLLLLSLLVLIISLEFWSTLGIVLSTRISSYQQRDIIMTLIFSPVAYAAPTLYVFSNNSPLIIKVLAYINPLSYQLKALRTVAFGIFNINDLLIALVLTIIMIIFAQIILRRMPLSLAER
>NC_008529.1|WP_011678003.1|275273_275984_-|metal-ABC-transporter-ATP-binding-protein
MISTNNLNIGYKDKVVVHDLSFSLDKGMFIALIGANGAGKSTLINSLIGVIPPVSGQISWKLKTDRVNPFNDVGFSPQSQLIDWYTSVYDNVYQGPLLAGFKPKEAQKTTKQALKLLDISDLSAKPVDHISGGQQQRVQIAREIARDPQVYILDEPTTGLDVETSENLFTYLKQKVDAGSIVLTSSHDLTLLESYASHVLFLDDHEQKYFGPLTDFLDSGTSLREKYLNERKAIEK
>NC_008529.1|WP_011543614.1|276109_276355_+|arginine-deiminase
MSIEFQKLIQKLQSDPITIGNFLADPEEFLKSTKLTNQEKKTLLARDVEALNDLGLTIDQAVGALSGAHSQRCSTNHPTRG
>NC_008529.1|WP_011543615.1|276376_276661_+|hypothetical-protein
MPAARIEKCFTDFIESYTNENNIYIGSATYFLYSKFIIESYGLPVENRYSVSEIASKLKQAGLDKVIVNYLIVRYLDGMYLLAQLQSKEETFWP
>NC_008529.1|WP_011678004.1|276657_277995_+|protein-kinase
MNKEDIAIQFELLLKEYSVARYEDSIWAFPDYPHHIKSNYGWKIHISAILTNAIQIARKFLTLNQKYHFDFKIISSIPYLEQMNMGYFGNSQVGKFITIYPDQSAVTETLELLYYYFHDDVGIRVGSDISYKQGLNVYYRYGTLLDDVENIDKRDKKLKPSSNVEKIYDYRLERYNSLPTRYLILKAIKQNGPSGVLLALDLQTKLKVIIRYADKYYNIESAGIDERDRLISASSLLEKDFVRNSSFFETVVDAFYVNDVFFVVTEYASGYNLDELAKNGQLGLYSLSERLEIFRNVLRGIYVLNDNLIIFRDLSFSNVILCPNHTIKIIDFGYAISLSGLSSFAGLTLNSAGTYGFFDPEVPIDKKQLDLYSLGKFLYYIVFPQSYLNYTSKIKSNSTYWQIKEYVSESEQCQLPKRIAELYRFLIKGKKIQESDLNYLIQRLQ
>NC_008529.1|WP_011678005.1|278259_278928_+|CPBP-family-intramembrane-metalloprotease
MNTPRSRKGNLVRYLVYFVVFVFTALADNLAIKSPSISIWNVILFLVLAAMCLLFYIYRYNREQRFFDSRFNIPWLSSFNFTLLLSFVVAAGRIGISYLQLYKGMPASGLQLAYASHSTSSLYWFMMLANGIVLPILEEYLCTGFLFNYWFRTEKKGVAYVGIICSGLFYAILTFQFTPAIFAFNFAFGMLFAWSYLSTQTIWLPLYLAALNGVLTVVTIAV

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Crispr_ID: NC_008529_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008529_2

756215-757463

TypeI-E

I-B,III-A,III-B

Consensus_repeat	Method
GTATTCCCCACGCAAGTGGGGGTGATCC	PILER-CR
GTATTCCCCACGCAAGTGGGGGTGATCC	CRISPRCasFinder
GTATTCCCCACGCAAGTGGGGGTGATCC	CRT

20 spacers

DEDDh,cas1,cas6e,cas5,cas7,cse2gr11,cas8e,cas3

The CRISPR arrays of NC_008529_2

>merge|NC_008529|2|756215-757463|PILER-CR,CRISPRCasFinder,CRT
GTATTCCCCACGCAAGTGGGGGTGATTCCGTTGACCGATTGCAGTTCGTGCTTTTGCGTGTGTATTCCCCACGCAAGTGGGGGTGATCCCAAACAGTTCGTCACTTAAAGCGTGCCATTTAGGTATTCCCCACGCAAGTGGGGGTGATCCGCCGGCCGGTTTGTCCAAAAAGGCTCTAAAGGGGTATTCCCCACGCAAGTGGGGGTGATCCTACTTTATTGCCACCGCAAAAGGATACAAAAGAGTATTCCCCACGCAAGTGGGGGTGATCCCGTGCCAAAAATTAAGTTCCTCCTCTACTAGCTGTATTCCCCACGCAAGTGGGGGTGATCCCTGATTGCTGGGGAAGCTGGGAACTGATTGCTGGTATTCCCCACGCAAGTGGGGGTGATCCCGAAGTTCGGCACCTTAAGGACAAGTCCGGAGAGTATTCCCCACGCAAGTGGGGGTGATCCTGGCAAGCCTCCTAGAATGGCAGGTCCGATTCGGTATTCCCCACGCAAGTGGGGGTGATCCCTGGAAGCTGGAACTGGAAGCTGGAACTGGAAGGTATTCCCCACGCAAGTGGGGGTGATCCAGAGACATAACAAAAAAAGACAGTCAGCGGTTAGTATTCCCCACGCAAGTGGGGGTGATCCCGTGTGTTAAAACGCCGTCGATTTCTTCTTCGGGTATTCCCCACGCAAGTGGGGGTGATCCCCTCCGCGTAGACCGGGATCTTCTCGCCTTCAAGTATTCCCCACGCAAGTGGGGGTGGATCCTGCCGTGGCAATGACCAAGATCAATCAGCAAGCGTATTCCCCACGCAAGTGGGGGTGATCCCGAGATCCCAGGTGGCTTTGTGATGTTTGTTTCGTATTCCCCACGCAAGTGGGGGTGATCCCCACGGGGACGCCTTCGGGGATTGGACCTCGGAGTATTCCCCACGCAAGTGGGGGTGATCCCCTGCTGGTTAAGGACAACTGGCACAGCCGCTAGTATTCCCCACGCAAGTGGGGGTGATCCTGCGATTAGCAAGATCTGTAAATCATGTTTTCGGTATTCCCCACGCAAGTGGGGGTGATCCTGATTTTCTTGACAGCTTAAGAAAAAAAGCTAAGTATTCCCCACGCAAGTGGGGGTGATCCCATAACCATAGTAGCTCAAAGCCCGATCAAGGGGTATTCCCCACGCAAGTGGGGGTGATCCAGTCCACGTGCGTTTGAAGAACAGCCTGCCTGTGTATTCCCCACGCAAGTGGGGGTGATCC

>NC_008529|2|1|756215-757463|PILER-CR
GTATTCCCCACGCAAGTGGGGGTGATTC	CGTTGACCGATTGCAGTTCGTGCTTTTGCGTGT
GTATTCCCCACGCAAGTGGGGGTGATCC	CAAACAGTTCGTCACTTAAAGCGTGCCATTTAG
GTATTCCCCACGCAAGTGGGGGTGATCC	GCCGGCCGGTTTGTCCAAAAAGGCTCTAAAGGG
GTATTCCCCACGCAAGTGGGGGTGATCC	TACTTTATTGCCACCGCAAAAGGATACAAAAGA
GTATTCCCCACGCAAGTGGGGGTGATCC	CGTGCCAAAAATTAAGTTCCTCCTCTACTAGCT
GTATTCCCCACGCAAGTGGGGGTGATCC	CTGATTGCTGGGGAAGCTGGGAACTGATTGCTG
GTATTCCCCACGCAAGTGGGGGTGATCC	CGAAGTTCGGCACCTTAAGGACAAGTCCGGAGA
GTATTCCCCACGCAAGTGGGGGTGATCC	TGGCAAGCCTCCTAGAATGGCAGGTCCGATTCG
GTATTCCCCACGCAAGTGGGGGTGATCC	CTGGAAGCTGGAACTGGAAGCTGGAACTGGAAG
GTATTCCCCACGCAAGTGGGGGTGATCC	AGAGACATAACAAAAAAAGACAGTCAGCGGTTA
GTATTCCCCACGCAAGTGGGGGTGATCC	CGTGTGTTAAAACGCCGTCGATTTCTTCTTCGG
GTATTCCCCACGCAAGTGGGGGTGATCC	CCTCCGCGTAGACCGGGATCTTCTCGCCTTCAA
GTATTCCCCACGCAAGTGGGGGTGGATC	CTGCCGTGGCAATGACCAAGATCAATCAGCAAGCGTAT
TCCCCACGCAAGTGGGGGTGATCCCGAG	ATCCCAGGTGGCTTTGTGATGTTTGTTTCGTAT
TCCCCACGCAAGTGGGGGTGATCCCCAC	GGGGACGCCTTCGGGGATTGGACCTCGGAGTAT
TCCCCACGCAAGTGGGGGTGATCCCCTG	CTGGTTAAGGACAACTGGCACAGCCGCTAGTAT
TCCCCACGCAAGTGGGGGTGATCCTGCG	ATTAGCAAGATCTGTAAATCATGTTTTCGGTAT
TCCCCACGCAAGTGGGGGTGATCCTGAT	TTTCTTGACAGCTTAAGAAAAAAAGCTAAGTAT
TCCCCACGCAAGTGGGGGTGATCCCATA	ACCATAGTAGCTCAAAGCCCGATCAAGGGGTAT
TCCCCACGCAAGTGGGGGTGATCCAGTC	CACGTGCGTTTGAAGAACAGCCTGCCTGTGTAT
TCCCCACGCAAGTGGGGGTGATCC

>NC_008529|2|2|756215-757463|CRISPRCasFinder
GTATTCCCCACGCAAGTGGGGGTGATTC	CGTTGACCGATTGCAGTTCGTGCTTTTGCGTGT
GTATTCCCCACGCAAGTGGGGGTGATCC	CAAACAGTTCGTCACTTAAAGCGTGCCATTTAG
GTATTCCCCACGCAAGTGGGGGTGATCC	GCCGGCCGGTTTGTCCAAAAAGGCTCTAAAGGG
GTATTCCCCACGCAAGTGGGGGTGATCC	TACTTTATTGCCACCGCAAAAGGATACAAAAGA
GTATTCCCCACGCAAGTGGGGGTGATCC	CGTGCCAAAAATTAAGTTCCTCCTCTACTAGCT
GTATTCCCCACGCAAGTGGGGGTGATCC	CTGATTGCTGGGGAAGCTGGGAACTGATTGCTG
GTATTCCCCACGCAAGTGGGGGTGATCC	CGAAGTTCGGCACCTTAAGGACAAGTCCGGAGA
GTATTCCCCACGCAAGTGGGGGTGATCC	TGGCAAGCCTCCTAGAATGGCAGGTCCGATTCG
GTATTCCCCACGCAAGTGGGGGTGATCC	CTGGAAGCTGGAACTGGAAGCTGGAACTGGAAG
GTATTCCCCACGCAAGTGGGGGTGATCC	AGAGACATAACAAAAAAAGACAGTCAGCGGTTA
GTATTCCCCACGCAAGTGGGGGTGATCC	CGTGTGTTAAAACGCCGTCGATTTCTTCTTCGG
GTATTCCCCACGCAAGTGGGGGTGATCC	CCTCCGCGTAGACCGGGATCTTCTCGCCTTCAA
GTATTCCCCACGCAAGTGGGGGTGGATC	CTGCCGTGGCAATGACCAAGATCAATCAGCAAGC
GTATTCCCCACGCAAGTGGGGGTGATCC	CGAGATCCCAGGTGGCTTTGTGATGTTTGTTTC
GTATTCCCCACGCAAGTGGGGGTGATCC	CCACGGGGACGCCTTCGGGGATTGGACCTCGGA
GTATTCCCCACGCAAGTGGGGGTGATCC	CCTGCTGGTTAAGGACAACTGGCACAGCCGCTA
GTATTCCCCACGCAAGTGGGGGTGATCC	TGCGATTAGCAAGATCTGTAAATCATGTTTTCG
GTATTCCCCACGCAAGTGGGGGTGATCC	TGATTTTCTTGACAGCTTAAGAAAAAAAGCTAA
GTATTCCCCACGCAAGTGGGGGTGATCC	CATAACCATAGTAGCTCAAAGCCCGATCAAGGG
GTATTCCCCACGCAAGTGGGGGTGATCC	AGTCCACGTGCGTTTGAAGAACAGCCTGCCTGT
GTATTCCCCACGCAAGTGGGGGTGATCC

>NC_008529|2|1|756215-757463|CRT
GTATTCCCCACGCAAGTGGGGGTGATTC	CGTTGACCGATTGCAGTTCGTGCTTTTGCGTGT
GTATTCCCCACGCAAGTGGGGGTGATCC	CAAACAGTTCGTCACTTAAAGCGTGCCATTTAG
GTATTCCCCACGCAAGTGGGGGTGATCC	GCCGGCCGGTTTGTCCAAAAAGGCTCTAAAGGG
GTATTCCCCACGCAAGTGGGGGTGATCC	TACTTTATTGCCACCGCAAAAGGATACAAAAGA
GTATTCCCCACGCAAGTGGGGGTGATCC	CGTGCCAAAAATTAAGTTCCTCCTCTACTAGCT
GTATTCCCCACGCAAGTGGGGGTGATCC	CTGATTGCTGGGGAAGCTGGGAACTGATTGCTG
GTATTCCCCACGCAAGTGGGGGTGATCC	CGAAGTTCGGCACCTTAAGGACAAGTCCGGAGA
GTATTCCCCACGCAAGTGGGGGTGATCC	TGGCAAGCCTCCTAGAATGGCAGGTCCGATTCG
GTATTCCCCACGCAAGTGGGGGTGATCC	CTGGAAGCTGGAACTGGAAGCTGGAACTGGAAG
GTATTCCCCACGCAAGTGGGGGTGATCC	AGAGACATAACAAAAAAAGACAGTCAGCGGTTA
GTATTCCCCACGCAAGTGGGGGTGATCC	CGTGTGTTAAAACGCCGTCGATTTCTTCTTCGG
GTATTCCCCACGCAAGTGGGGGTGATCC	CCTCCGCGTAGACCGGGATCTTCTCGCCTTCAA
GTATTCCCCACGCAAGTGGGGGTGGATC	CTGCCGTGGCAATGACCAAGATCAATCAGCAAGC
GTATTCCCCACGCAAGTGGGGGTGATCC	CGAGATCCCAGGTGGCTTTGTGATGTTTGTTTC
GTATTCCCCACGCAAGTGGGGGTGATCC	CCACGGGGACGCCTTCGGGGATTGGACCTCGGA
GTATTCCCCACGCAAGTGGGGGTGATCC	CCTGCTGGTTAAGGACAACTGGCACAGCCGCTA
GTATTCCCCACGCAAGTGGGGGTGATCC	TGCGATTAGCAAGATCTGTAAATCATGTTTTCG
GTATTCCCCACGCAAGTGGGGGTGATCC	TGATTTTCTTGACAGCTTAAGAAAAAAAGCTAA
GTATTCCCCACGCAAGTGGGGGTGATCC	CATAACCATAGTAGCTCAAAGCCCGATCAAGGG
GTATTCCCCACGCAAGTGGGGGTGATCC	AGTCCACGTGCGTTTGAAGAACAGCCTGCCTGT
GTATTCCCCACGCAAGTGGGGGTGATCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008529.1\|WP_011678175.1\|746831_749597_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|182031
NC_008529.1\|WP_011543823.1\|751968_753045_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NC_008529.1\|WP_041813510.1\|751342_751951_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	mkCas0194_cse2gr11_CAS-I-E	gnl\|CDD\|378191
NC_008529.1\|WP_011678186.1\|767167_769432_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NC_008529.1\|WP_003619878.1\|753739_754363_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl\|CDD\|378050
NC_008529.1\|WP_011678182.1\|759003_760263_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_008529.1\|WP_011543818.1\|745052_745256_+\|hypothetical-protein	unknown	unknown	unknown
NC_008529.1\|WP_011678180.1\|757721_758336_+\|GTP-pyrophosphokinase	unknown	unknown	gnl\|CDD\|225232
NC_008529.1\|WP_011678183.1\|760417_761518_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NC_008529.1\|WP_011678179.1\|755312_756185_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|176648
NC_008529.1\|WP_003619876.1\|753025_753727_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl\|CDD\|187886
NC_008529.1\|WP_003619893.1\|762750_763914_+\|hydroxymethylglutaryl-CoA-synthase	unknown	unknown	gnl\|CDD\|213655
NC_008529.1\|WP_011678185.1\|766082_767027_+\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|234786
NC_008529.1\|WP_003619897.1\|765495_766002_-\|aminoacyl-tRNA-deacylase	unknown	unknown	gnl\|CDD\|237976
NC_008529.1\|WP_172793909.1\|743609_743885_+\|hypothetical-protein	unknown	unknown	unknown
NC_008529.1\|WP_011678176.1\|749599_751324_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09729_cas8e_CAS-I-E	gnl\|CDD\|187860
NC_008529.1\|WP_011678181.1\|758332_759001_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_008529.1\|WP_003619879.1\|754365_755316_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NC_008529.1\|WP_011543831.1\|764078_765437_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NC_008529.1\|WP_011678184.1\|761520_762747_+\|hydroxymethylglutaryl-CoA-reductase,-degradative	unknown	unknown	gnl\|CDD\|153082

Protein	Function_ID	Function_description	E-value
NC_008529.1\|WP_011678175.1\|746831_749597_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	8.88153e-81
NC_008529.1\|WP_011543823.1\|751968_753045_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	6.98022e-156
NC_008529.1\|WP_041813510.1\|751342_751951_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	2.50333e-28
NC_008529.1\|WP_011678186.1\|767167_769432_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NC_008529.1\|WP_003619878.1\|753739_754363_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	3.4353e-70
NC_008529.1\|WP_011678182.1\|759003_760263_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.12639e-29
NC_008529.1\|WP_011678180.1\|757721_758336_+\|GTP-pyrophosphokinase	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	4.94996e-63
NC_008529.1\|WP_011678183.1\|760417_761518_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.44133e-160
NC_008529.1\|WP_011678179.1\|755312_756185_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|176648	cd06127, DEDDh, DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI, ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III, the main replicating enzyme in bacteria, which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T, Oligoribonuclease, and RNA exonuclease (REX), among others.	8.71436e-44
NC_008529.1\|WP_003619876.1\|753025_753727_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|187886	cd09756, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	1.10741e-53
NC_008529.1\|WP_003619893.1\|762750_763914_+\|hydroxymethylglutaryl-CoA-synthase	gnl\|CDD\|213655	TIGR01835, 3-hydroxy-3-methylglutaryl_CoA_synthase, 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade. This clade of hydroxymethylglutaryl-CoA (HMG-CoA) synthases is found in a limited spectrum of mostly gram-positive bacteria which make isopentenyl pyrophosphate (IPP) via the mevalonate pathway. This pathway is found primarily in eukaryotes and archaea, but the bacterial homologs are distinct, having aparrently diverged after being laterally transferred from an early eukaryote. HMG-CoA synthase is the first step in the pathway and joins acetyl-CoA with acetoacetyl-CoA with the release of one molecule of CoA. The Borellia sequence may have resulted from a separate lateral transfer event.	9.16099e-131
NC_008529.1\|WP_011678185.1\|766082_767027_+\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|234786	PRK00517, prmA, 50S ribosomal protein L11 methyltransferase.	3.88931e-91
NC_008529.1\|WP_003619897.1\|765495_766002_-\|aminoacyl-tRNA-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	1.02683e-65
NC_008529.1\|WP_011678176.1\|749599_751324_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|187860	cd09729, Cse1_I-E, CRISPR/Cas system-associated protein Cse1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; subunit of the Cascade complex; signature gene for I-E subtype; also known as Cse1/CasA/YgcL family.	4.30303e-95
NC_008529.1\|WP_011678181.1\|758332_759001_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.93129e-67
NC_008529.1\|WP_003619879.1\|754365_755316_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	5.67957e-143
NC_008529.1\|WP_011543831.1\|764078_765437_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	5.84401e-63
NC_008529.1\|WP_011678184.1\|761520_762747_+\|hydroxymethylglutaryl-CoA-reductase,-degradative	gnl\|CDD\|153082	cd00644, HMG-CoA_reductase_classII, Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR). Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR), class II, prokaryotic enzyme is a homodimer. Class II enzymes are found primarily in prokaryotes and Archaeoglobus fulgidus and are soluble as they lack the membrane region. Enzymes catalyze the synthesis of coenzyme A and mevalonate in isoprenoid synthesis. Bacteria, such as Pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3-hydroxy-3-methylglutaryl-CoA. Human and bacterial HMGR differ in their active site architecture.	0

>NC_008529.1|WP_011678179.1|755312_756185_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MIVITLTKTPPALRGDLTRWCQEIQTGVYVGDVNARVRDKLWERVQTNIGNGEATLVYNTNNEQGYAFKTTRKSKQVVDLDGMLFVKHVVNQETVKHGFSNAAKFHKAHKAEKMRASVAATKQKRFVAVDIETTGLNTESDQILSIGAVKHDGIEFYRLIKQDIDVPKQIVELTGITSEMLSKEGVPLQDALEELTDFVGNVPIVGYNFRFDSVFLNRDYRKCGMQELKNEIKDLLPVVKRREKFLDNYKLQTVLSNYGIENKVPHNAVSDARATKELAMKLIKNRILVI
>NC_008529.1|WP_003619879.1|754365_755316_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MKVEASYKKPDLTELGRTEDRITFLYIEHAKLYRKDGAVEVRDEEGIVYVPAAIISVLLLGPGVDVTHRAMELMGDSGMAVVWVGEQGVRQYAHGRALNRSSRLLEAQAKLVSNVRSRVAVARKMYQLRFPDEDVTKLTMEEMRGKEGTRVRRVYREQAKKTGVKWSKREYKVDDFESETPINKALTAAHQALYGLSYSVIVALGASPGLGFIHTGHDLAFVYDFADLYKADISIPIAFETVAKYGDDDIASRIRHAMRDKFRETKLIKQMVVDLKHLLLGDADQDQDIDVMNLWDDKLGLQKFGVQYHEQQSDEE
>NC_008529.1|WP_003619878.1|753739_754363_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MYLSRVEIDTDNRQKIKDLSHLGAYHNWVERSFPAEIAEGERQRHLWRLDTLNGRNYLLLLSPEKPDLHEFERYGKPGTAISKDYEPFLSRLSEGQLLQFKLTANPVRRGGKSSSHPGSLIPCFAVDEQMKWLQGKAEKNGFELVAAEVVGHDRPLLRKKTHVALNRTVFEGRLKISNLDQFKAMLTSGIGREKAFGMGLMTVIPVD
>NC_008529.1|WP_003619876.1|753025_753727_+|type-I-E-CRISPR-associated-protein-Cas5/CasD
MKTLTIKLTAPLQAYGNEASFERRTSWPAPSKSAVVGMIAAALGMRREDERIKSLNDLAYAVRVDQIGKTMTEFQTVEWKPGTRKLTYRDHYQDAVYVAAVGSEDEELIGKIEYALKHPRFQLYLGRRACPPAGVLRIESFADTDPVKVLENMPWQAEKWYQNKQKRKAEFTAEIIADANLLPDAAFTQTVKDRVESFDPQGRCFGFRLTAKERINLKNPCYEQKSQDIMDYL
>NC_008529.1|WP_011543823.1|751968_753045_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MTKNLYVDINVLQTVPSSNINRDDTGAPKTAFYGGVTRARVSSQSWKRAVRKAFAEDGANIGTRTKRVPQMLAAKLQDLDASLDEDAAMSKAIDALKEGGIKTNKDNETGALLMVSPGQVAKLASYVLENETLDKKEVKKILMEGNSLDLALFGRMVADNPELNVDASAQVAHAISTHEIIPEYDYFTALDDLQEKEKSGAALIQTTQYDSATLYRYANINMAELSYNLGDEDAIEGALTFVKDFALSMPTGKQNSFANKTLPNYLMVTVRDDTPVNLVSAFESPVVAKAGEGYVENSVKKLENEYKDALQFVDQPLATVTVGKYETTVGEQAGNLQDLLGKLQDVLKKAVENEDFNN
>NC_008529.1|WP_041813510.1|751342_751951_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MAFEIEKATERIIRQLYNNGDTDKASLSALRSAATIDGYRAQKVWPVFLSNLDEQWLSKNGKATREEAAIFVAVRMYARHQQASDSCVFGRRNYSDKKDEETNSRELFEALNWLKQGIDSHEALDRRVQALLGTNNYNAVIDQLVHLMQIIKSKKTGIKIDYARLAGDLYKFQFGYRQANEVRLRWGEQYYRAFKKLDTNQQ
>NC_008529.1|WP_011678176.1|749599_751324_+|type-I-E-CRISPR-associated-protein-Cse1/CasA
MESYNLITEPWIKVLDGKTNSEHMVSIKELLQNASDYRQLAGEMHAQDLAVLRLLEAILTTVYTRVDQNDEEYEWVTLDEQMHVQSYDDEIEGSTLLQVLTKTWNALYKEGSFSEAVFDYLDKNKGLFDFFGDRPFYQVTAEQYDSFVPDNKKIAKGSGTVDLMQINRLISQSGNSVAIFSPKSANRKNKLTLDELVRWVITYQNFTGVTDKTKVKAKEKMSNSRGWLYTLNPVYAQGKNLFETLMLNLLLFNPNKPAYTQQRPVWEEDLGEYVKRRLSQVKPDNFAETYTVWSRLLHIEWQDGTPTIFSAGLPAFDSANAYDIEPMSTWRMNKKDENYYPATRQLSSIGIAMWRNFGQYVDIEGHTESREPLTVAWLNYLKTKNEFLNQQMINLHTSGIISNGGATSLMPAAEFDDNLRIEADVLFDETEDRKNAWPQRIEEMVDLNQEVGRKYYGFLMEVGRIRFGPQGATDFAGRKSQTFYDNLNEPFENWLANLSGGDDRDKQQELWKKQLRQIALRTLDDFLEIIAPRDISGIKADKSQSGTKSTESNIFIAANKYRAGINKALNKNEK
>NC_008529.1|WP_011678175.1|746831_749597_+|CRISPR-associated-helicase/endonuclease-Cas3
MKLSKEALSLWGKKSNQDGDEHWLPLVAHMVDTMNVGHWLYNSWLSEGQRSMLTTRICDAEMSKLVSFLCYIHDLGKATPAFQTKESYNHDHQLDEELIHRLVSHSFKKLNDLSLPSRSKSPHARAGEAILERAGLNETIAAIVGGHHGKPQNGDQEEQIDVFTSNYYQADNDEEIQQPWKDAQRELIDYGLELAGYEDISEVPPVNQPEAVILEGLLIMADWLASSTCLNNDPDKPMFNLIGLDQSFDDLDMKARYQNAISTWAINDAWIPEEVANVDDYYEQHFSFKPRQIQAAMEEHVKEAVDPGLVIIEAEMGIGKTEIALTAAEQLAYVTGRTGVYIGLPTQATTNAMFDRVNSWLTKIAGIEGINPDIKLLHGKAEWNSRYTDLPRAEDIEAEELDAGTVTVNSWFSGKKSILADFAVGTIDNLLLMGLKQKHLFLRHLGFSNKVVIIDEVHAYDMYMQSYLSKALKWLGAYHVPVVILSATLPKEKRNELIKSYTKGKNRRVKKVLQAQEGWESNRAYPLLSLLDGKELRQYSDFGPKAEPREMQLNYINDEPTEVLAKVNDKIKDGGIAGIIVNTVKRAQEFAGLVGQDCQCLVLHSAFLATDRSRLEKELQSLIGKKGKRPDKLIVIGTQVLEQSLDIDFDVMFTDIAPIDLLLQRAGRLHRHKISRPKGLEKRQLYVMKPDSDDYGPANEAVYEKYYLQKTEHFLPQKIQLPNDISRLVQLVYDEDTDDQVENLDEARDKLNVDRNREKSKAESFQINDPVYPAAKNDLYDDTWVEELTIHRWLDRDKGNLDDNQASAAVRDIRESIEVILLKEISGEYYLMNGDKVSEMVDKDLAKELIRLPNAVTPNIEQAINILEENTAQAFPDWQGSPWLKGSLAVVLDEHAKGSFNGYKLRYSTETGLSYEKEVDN
>NC_008529.1|WP_011543818.1|745052_745256_+|hypothetical-protein
MGESKEDKRMRAKWESLSGAEKSEFKKNYAMRRGITIDFIRRWAWNEGDLDNLEYHIAERRKKFREF
>NC_008529.1|WP_172793909.1|743609_743885_+|hypothetical-protein
MTDLAQLGGDELKEILDEKRRSRWLYQPLRAADPGASQAGRQEEVRRDKFFRLGDCDMKKCGPAKLPVRLTRSRTTSTNPSVLTKECIHKT
>NC_008529.1|WP_011678180.1|757721_758336_+|GTP-pyrophosphokinase
MSIYGKYADYLPQILDSVLQQIQGIGQEYSAEHGQKLYGHLEGRVKGEESMAQKCERKGLPLMPESALIENRDAIGLRIVCNFIDDIYTCIDLLKKQDNFKIINEKDYITDAKPNGYRSYHLIMEVVTPFEDVHGNKPGTYYVEIQLRTIAMDTWASLEHEMKYKHDIKNPERISKELKRVADELASCDVSMQTIRQLIKEGEL
>NC_008529.1|WP_011678181.1|758332_759001_+|response-regulator-transcription-factor
MKILLAEDEAQLNRVLTVAMQKSGYDVDSVFNGQEAVDAVKKHPYDVIIMDIMMPVKNGLDAVKEIRSTGDKTYIMMLTAKSEIDDKVTGLDVGADDYLTKPFSLKELLARLRSKERRSEDYNSTQELNYDNLKLDLNSQELSSNNSISLSKQETGLMRYFLLNPGKAISTEELFNHVWKNEDESEDVVWVYISFLRSKLASIGANVQISGEKGGEFCLERA
>NC_008529.1|WP_011678182.1|759003_760263_+|HAMP-domain-containing-histidine-kinase
MIKKIRRRFIWLATLSLFLVMFFSFSSLIGISLFESSHEADQVLSIIVKNNGRLDEVQAKKRLGDQYNKEGMFKYRYFTANINTKKQTLTVIDADHIIGYSINSVSSRKKQISRRLSAGQLKGTIHSNGVRFRYLAKKISANKYYICFIDLSPLMQSALLLVRYALIFTFGGILFFVIIMTLLADKAIQPIKDAYYKQRRFITNAGHELKTPLAVISANAEMEELLGNDDEWSESTKEQVVRMTGLINQLITLTRMSEPGELVLSKVNFSEIIKESADSFKSVLAKDNKKYVVSIDPDLYINAEQRSLLELVNILIDNAQKYCDPEGEVMVVLAKSRLNQNAVLTVTNSYKNGAGIDTNRFFERFYREDESHHYDQKQKNGFGIGLSMAQDLVAAFGGKINASWSDGVMNFTVTFKRVH
>NC_008529.1|WP_011678183.1|760417_761518_+|thiolase-family-protein
MQDIYIVAAKRTPFGRYHKQLADFSAIDLGQIALRGALKEAGLDAESLDALFMGNVLSAGLGQNMARQIALNAGMRQDSVAVSINEVCGSSLKAARLAEAQMLIGDLGLVAVGGSESMTNASKEIMFSDGLVDSFSGKSMGITAENVAKRNHISRQDADAFSLSSHQKAVKAQAEGLFADEIIQIEDLKQDENVRPDTSLEALAGLKTSFLEDGTVTAGNASPISDGASMIILATAEKVAEYQLTPLAKLGAYAEVGYDPEFMGYGPYYAIRKLLNETGRQVADYDFFEINEAFAATTLAVARDLEIPLAKVNKQGGAIALGHPLGASGTRLLATAARQLQRGGQRAIASLCIGGGLAIAFEIEKA
>NC_008529.1|WP_011678184.1|761520_762747_+|hydroxymethylglutaryl-CoA-reductase,-degradative
MKFYQLPPEERRQFLQEDGVALEDIPAADLARLDEMSENVVGEVKFPLSCLTSALVNGKNWRIPMTTEEASVVAAANHGMSVFAKAGGVKATSQRDGIYGQIVLEVTEAFSLAGFKKEFPAYIKEANKEFASLIRHGGGLKDLTARQEADLVYLLALVDPAEAMGANKTNAILEFLAQKMLAFPGVEAKLFAILSNYPSQLTTAKVAIPVSLLSKKGDLAEGREVAKKMALLAKIGSSDPYRAVTNNKGIMNGVDAVMLATGNDYRAVEAACHAYAAKSGEYRSLSSWKIAGEKLLGQVTLPLALGVVGGSISSRPDIRQSYAILGKIKAAELAELTASVALANNFAALSAISTKGIQAGHMRLQSRNVVQTLPASAEEKAAVYQMMISQGKYGETAAKNFLKELRGQ
>NC_008529.1|WP_003619893.1|762750_763914_+|hydroxymethylglutaryl-CoA-synthase
MDIGIDQIGFYTPNKFVDMVDLANARNQDPNKFLIGIGQDRMAVADKTQDAVSMGINATAEYLDQVDLEQLGLLIFATESGIDQSKSASLFVKEALNLPARIRTFEIKEACFALTASLQVARDYVRAHPHHSAMIIGSDIARYGLATAGEVTQGAGAISMLIKENPAIIALEDGHTSHSENINDFWRPNNLATAVVDGHYSRDVYLDFFKSTFKPFLAEKQLQVSDFAGICYHLPYTKMGYKAHKIAIEGQDDETVKRLSDNFQLSAKYSRQVGNIYTASLYMSVLSLLENGDLEAGDRIGFFSYGSGAMAEFFSGKVVAGYQKRLRPALHARMLKERIRLGVGQYEDIFTEGLEALPENVEFTSDANHGTWYLAGQEGYVRQYKQK
>NC_008529.1|WP_011543831.1|764078_765437_+|threonine/serine-exporter-family-protein
MKTESTEQEYQHHLSHHHHMRVQWEEFFQSDDETKIKEATLIEKGSIISRVGMMILSCGTGAWRVRDAMDTLARTLDLTCSTDIGLISIVCTYFDVDNQSYSQSLALPTTGVNMAKLNELEKFVRQFEAAGGDFEIKTVRRRLGEIEHMKGRYPLWGSSLAAALACGGFIFLLGGGLPEIICSFIGAGLGQFARGSLAKRRITVAATTAVGVAAACLSYYLAFMLGHLLFNVDMIHMRGYIGAMLFVIPGFPFITSGLDIAKLDMRSGLERMAYAILIILIATGTGCVMATALQIKPGDLPALHLSKAILTACRLLASFCGVFGFSLMFNSHRRMAAAAGLVGAIANTMRLSLVDFAHFPAPLAAFLAALLAGLLAGYVREKVGYPRIALTVPSIVIMVPGLYMYRGIFFLALTNVGAGATWMTEALMLVMSLPAGLLTARILNDKKWRRVD
>NC_008529.1|WP_003619897.1|765495_766002_-|aminoacyl-tRNA-deacylase
MSKKKKNKDKLDKTLVEKILDQHKIAYEQHISEISEDHGVAQVGTGKPVLDGHPVYKTLAVNGNKTGPIVGVVPLSGHLDLKKIAKASGNKKCEMIPLKQLEKTTGYVHGANTPIGIYHSKKFPIFLDESVLKEDGIWVSSGEVGRSVMVNPLDLQKLVKATVADLQE
>NC_008529.1|WP_011678185.1|766082_767027_+|50S-ribosomal-protein-L11-methyltransferase
MKLLEIKIESSYDVEDALAYFATEDLKALGTEARRRSDFEQAGWLHDSTVVDMDDIPNLPDELEFIAYFDEETDPEEMVKCFKDKLAELAGYGLKTAPGEISVDYVADQDWNTVWKKYYHVINLSRHLAIVPEWEDYQPVFKDQEIIRLDPGLAFGTGNHQTTQLAMLGIERAMVKPLTVADVGTGSGILAIAAHKLGAKSVLATDISDESMTAAEENAALNGIYDIALQKTSLLADVDGKFDLIVANILAEILLDLIPQLDSHLNEDGQVIFSGIDYLQLPKIEQALAENSFQIDLKMRAGRWIGLAISRKHD
>NC_008529.1|WP_011678186.1|767167_769432_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MSKYTEMTHEQVMAACNKYMTANQLAFVESAYQFAARAHEGQTRASGQPYIVHPTQVAGTLANLGLDPDTVAAGFLHDTVEDTSVTNDDIKEKFGADVAFIVDGVTKLNKYEYKSHKEFLAENHRKMLIAMAKDLRVILVKLADRLHNMHTLEHLLRPDKQRRIAAETLDIYAPLADRLGIGTIKWKLEDMSFHYMNPEAYYKIVSMMDAKRSEREGYIKDAIDYLRGTLDSLGIKYDISGRPKHIYSIYKKMVNKHKNFNEIYDLLAVRVIVPTVKDCYAVLGAVHTKWKPMPGRFKDYIAMPKANGYQSLHTTIIGPGGKPLEIQIRTEEMHKVAEYGVAAHWAYKRGNFQGVDEKEGGALDIGREILELQKDSSDADEFMEAVHSDIFADKVYVFTPKGEVYELPKGSVTLDFAYAIHTQVGDHAIGAKVNDKLVPLDYKLKNGDVVDILTQSNARPSRDWAEMVKTSRAKNKIRRYFRDVDREESLARGKSELVDLLKENGLSAKDFLDKSHIDEVLDHFSFKTDEDMYAAIGFGNMSAVSIYNRLTADLRRQQEEEKQKQFEAQIMSAGQQAAASSVVKKPAPQKDDAKSKTKGKKPDSLVRVQGLEDLDMHFAKCCNPVPGDLIVGYVTKGRGVTVHRVDCRNVVSADPAAQGRMIDVEWNNIDEGKQASFNANFELFGYNRQKLLGDVINRLNALTKNITNVSASVNEENIAHFYITVEVRNAAQLNDIMAKLRDIPDVYDTKRTDN

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Crispr_ID: NC_008529_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008529_3

1766162-1766264

Orphan

Consensus_repeat	Method
GTTGGCGTAGGGGAGTGAGAACGATGAAGATCGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008529_3

>merge|NC_008529|3|1766162-1766264|CRISPRCasFinder
GTTGGCGTAGGGGAGTGAGAACGATGAAGATCGATGTTATTCGATACCTCGACGACAGTGGTATAATAGTTGGCGTAGGGAAGTGAGAACGATGAAGATCGAT

>NC_008529|3|3|1766162-1766264|CRISPRCasFinder
GTTGGCGTAGGGGAGTGAGAACGATGAAGATCGAT	GTTATTCGATACCTCGACGACAGTGGTATAATA
GTTGGCGTAGGGAAGTGAGAACGATGAAGATCGAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008529.1\|WP_003620452.1\|1757911_1758412_-\|O-acetyl-ADP-ribose-deacetylase	unknown	unknown	gnl\|CDD\|394878
NC_008529.1\|WP_003620465.1\|1765390_1766059_+\|cobyric-acid-synthase	unknown	unknown	gnl\|CDD\|225974
NC_008529.1\|WP_003620463.1\|1763684_1765193_-\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|234594
NC_008529.1\|WP_011678671.1\|1775503_1776589_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237139
NC_008529.1\|WP_003620448.1\|1756602_1757517_+\|hypothetical-protein	unknown	unknown	unknown
NC_008529.1\|WP_002879459.1\|1757575_1757815_-\|hypothetical-protein	unknown	unknown	unknown
NC_008529.1\|WP_003620443.1\|1755403_1755709_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NC_008529.1\|WP_080504252.1\|1769266_1769803_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_008529.1\|WP_003620455.1\|1758411_1759194_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NC_008529.1\|WP_155589469.1\|1768921_1769095_-\|hypothetical-protein	unknown	unknown	unknown
NC_008529.1\|WP_003620462.1\|1762892_1763651_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NC_008529.1\|WP_011678674.1\|1779667_1780591_-\|dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235982
NC_008529.1\|WP_011678672.1\|1776588_1777866_-\|dihydroorotase	unknown	unknown	gnl\|CDD\|236479
NC_008529.1\|WP_011678670.1\|1772322_1775511_-\|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|235393
NC_008529.1\|WP_011678662.1\|1753553_1754957_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NC_008529.1\|WP_011678669.1\|1770191_1771073_-\|transposase	unknown	unknown	gnl\|CDD\|379252
NC_008529.1\|WP_003620469.1\|1766612_1768703_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NC_008529.1\|WP_003621085.1\|1778966_1779509_-\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	unknown	unknown	gnl\|CDD\|235365
NC_008529.1\|WP_011678666.1\|1759305_1760886_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_008529.1\|WP_011678673.1\|1777865_1778822_-\|aspartate-carbamoyltransferase-catalytic-subunit	unknown	unknown	gnl\|CDD\|234849

Protein	Function_ID	Function_description	E-value
NC_008529.1\|WP_003620452.1\|1757911_1758412_-\|O-acetyl-ADP-ribose-deacetylase	gnl\|CDD\|394878	cd02908, Macro_OAADPr_deacetylase, macrodomain, O-acetyl-ADP-ribose (OAADPr) family. Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. This family includes eukaryotic macrodomain proteins such as human MacroD1 and MacroD2, and bacterial proteins such as Escherichia coli YmdB; these have been shown to be O-acetyl-ADP-ribose (OAADPr) deacetylases that efficiently catalyze the hydrolysis of OAADPr to produce ADP-ribose and free acetate. OAADPr is a sirtuin reaction product generated from the NAD+-dependent protein deacetylation reactions and has been implicated as a signaling molecule. By acting on mono-ADP-ribosylated substrates, OAADPr deacteylases may reverse cellular ADP-ribosylation.	3.16627e-94
NC_008529.1\|WP_003620465.1\|1765390_1766059_+\|cobyric-acid-synthase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	1.65312e-72
NC_008529.1\|WP_003620463.1\|1763684_1765193_-\|glycerol-kinase-GlpK	gnl\|CDD\|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NC_008529.1\|WP_011678671.1\|1775503_1776589_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NC_008529.1\|WP_011678673.1\|1777865_1778822_-\|aspartate-carbamoyltransferase-catalytic-subunit	gnl\|CDD\|234849	PRK00856, pyrB, aspartate carbamoyltransferase catalytic subunit.	2.96656e-157
NC_008529.1\|WP_003620443.1\|1755403_1755709_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	0.00184686
NC_008529.1\|WP_080504252.1\|1769266_1769803_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	5.92853e-37
NC_008529.1\|WP_011678669.1\|1770191_1771073_-\|transposase	gnl\|CDD\|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.09849e-10
NC_008529.1\|WP_003620462.1\|1762892_1763651_-\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	4.34098e-65
NC_008529.1\|WP_011678674.1\|1779667_1780591_-\|dihydroorotate-dehydrogenase	gnl\|CDD\|235982	PRK07259, PRK07259, dihydroorotate dehydrogenase.	8.51773e-166
NC_008529.1\|WP_011678672.1\|1776588_1777866_-\|dihydroorotase	gnl\|CDD\|236479	PRK09357, pyrC, dihydroorotase; Validated.	0
NC_008529.1\|WP_011678670.1\|1772322_1775511_-\|carbamoyl-phosphate-synthase-large-subunit	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
NC_008529.1\|WP_011678662.1\|1753553_1754957_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NC_008529.1\|WP_003620455.1\|1758411_1759194_-\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	1.57569e-73
NC_008529.1\|WP_003620469.1\|1766612_1768703_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NC_008529.1\|WP_003621085.1\|1778966_1779509_-\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	gnl\|CDD\|235365	PRK05205, PRK05205, bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR.	2.43573e-98
NC_008529.1\|WP_011678666.1\|1759305_1760886_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.01911e-65

>NC_008529.1|WP_003620465.1|1765390_1766059_+|cobyric-acid-synthase
MDDNLIRIAYLYEDLMNTYGDSGDVKILRYFLQKKGWQTQIDNISLGSQFNAADYDFVFFGGGQDYEQSIVAKDLQRFKETLNDYIQAGNPMLAICGGYELMGTHYNTISGTKIKGLGILPLHTEFDPEKRMIGDTKYETEWGPTIGFENHSGQTFLDDRKMLKPFAKVVEGYGNNHEEKEDGVRYKNFIGSWSHGPMLKNENVANALVDMILKRHAARVAQ
>NC_008529.1|WP_003620463.1|1763684_1765193_-|glycerol-kinase-GlpK
MSEQYILAIDEGTTSTREIIFNYAGQQVASVAREFTQYFPKPGWVEHQAEEIWNAVQITTSTALINSAIRPDQLAVIGITNQRETTVVWDKETGRPIYPAIVWQSRQTSDIAEKLVKDSYSEMIRQKTGLVIAPYFSATKIRWILDHLEGAQERAEKGELLFGTIDTWLVWKLTRGKVHVTDCTNASRTMLFNIHDLTWDQEILDLLKIPRTMLPEVKSNSEVYGETDPYQFFGGRVPIAGMAGDQQAALFGQLAVKPGMVKNTYETGSFIVMNTGEEPIESKNNLLTTIGYKLGDQVNYALEGSVFVAGSAIQWLRDSVKLLNSAPESEQAALESKDANEVYVVPAFTGLGAPYWDSEARGAIFGLTRGSSDKDLIKATLQSLAYQTRDVVDTMQKDSGIEIPVLRVDGGASNNNYLLQFQADLLGKKIERAADLETTGLGAAFLAGLAVGYWQDLDSLKEIAKTGAAFAPKMEEAERDRLYAGWQRAVLATRVFAHGKDF
>NC_008529.1|WP_003620462.1|1762892_1763651_-|tyrosine-protein-phosphatase
MPKRIVKLEAGYNCRDLGGYVSQDGRTVKWGRLYRSGSLSHLTKADQAELARRKIVVDCDLRSRHEQDNFPDKLWPGSKLVDAHFYSESGDEEEEAEAAWEKYSSKLPKLSYLAMVYQQNLVVPRTGLVMREIFKEMLDLEDDEALLYHCSMGKDRTGMVSVIVLMALGLEDREILRDYLLSREYSRDWDEADENDRLGKQIAKMNQTQVSQTAFYGITETIRQMWGGFDRYFASLGFDQGDLDRLRDKFLE
>NC_008529.1|WP_011678666.1|1759305_1760886_-|ABC-transporter-ATP-binding-protein
MKIGELVKQNRLRFTCAVALEVLGQLCVAVGNYIIGFILDLLVKRETSRFYLVLAVFFVLYIGGYVLISFAEYLYIVQVQEYVHQLRRKTVDYYYQNHETVAEMQSHLTNDFQMLFDNFTQPLFVFFDSALAVVFSAYALVTMHWILLVTTVLLSVMFLYLPSIFSKKYQERTLIFSNMNTAYLTSIKNWLGGLAEIQRYDARHKLVEVLEKRSKKLEGSLVTRQVSAIEINFINGFMSIFCQVVLDVVTGALILAGTISIGKLVAVGQFSSTIFNSLVMLSNYLEQIKSTKPLNEKVAAALADPPKDVCTDEELTSFDHLQTTGLSFSYDHGETINYPDLKIKVGEKILLTGDSGTGKSTLLKVLAGELKATTGNIAFYDHDDRKIDISLKAMHYVPQDPVLFPVSIAENITMFKPKLDDKVGEYLQKVDLAKDIAKFPKGQDTVIDVEELNVSGGQRQKIVLARAELNQSDFILIDEATAAVDQDSTKRILKNLLKTNATIIFIGHNFTNEMVDMFDRQIVLSK
>NC_008529.1|WP_003620455.1|1758411_1759194_-|tyrosine-protein-phosphatase
MEMQRVIELDMPVNFRDLGGYQGLDGRQVKWRKIYRSAALNEMSARDRVKLANLRITVDCDLRSSREQRSYPDLLWPGVRFVNIGLYAEGDRFNQAHPFLRLFHHLPEFDDYLPKIYQQVLLNEHSEEGIKRVFEELLKLPEDQALVYHCAAGKDRTGIISILILMALGVDDKTIAEDYLLTDELYDFSIEKQHPTNEKLSQVIAKMNVTRGEGTAVKGITETIRQGWGSFDKFFTRKLGFKQADLEKFREMYLEEEEED
>NC_008529.1|WP_003620452.1|1757911_1758412_-|O-acetyl-ADP-ribose-deacetylase
MNLEIWQGDITTLKVDAIVNAANRELRGGGGVDGAIHRAAGPKLNEACRALGSCETGEAKITPGFNLPAKYIIHTVGPVYSGSHSDPLLLAACYRNSLRVAKENGLHSVAFSAISTGVYGYPLDAASKVAFGEVRKWLREHKDYEMRVIMVAYDARTYALYQKLLG
>NC_008529.1|WP_002879459.1|1757575_1757815_-|hypothetical-protein
MLRKYYVTIVFTLLALLNLLSSWGTLQYRLVMLALNLVCGFGMEYLVNKKAPAEKYNLWKGCTAAVLLAVNLLWIFLTK
>NC_008529.1|WP_003620448.1|1756602_1757517_+|hypothetical-protein
MARMSRRQYQERQEQTAQKQTRQTNPNSVPRLDTDGASRSEQKVRLNFWQIFADRPYVTVIMISLALFCILAKWWIGLAIIIILTIAGIFVIGRSHHPNRVLSLEFKLKASRKLSMIKALQLLGSTIMFLAAYMRQIVSVDFSSAGATDSLTVIQNMLSNQGTFGQQGSYFLSLFNQLTGGSLWGTYRYATNSSQMMNSTAGTMIILWIFLLMIAPAFCVLSQFFREPYSRHVMTVASLISTISFTLTPTLMNRWVISYAVQNQMSQAAAENAVQVGGMVYPAIISAVFVFILAIYREIKKDEF
>NC_008529.1|WP_003620443.1|1755403_1755709_-|LPXTG-cell-wall-anchor-domain-containing-protein
MQSASEETSTAKKANDDAVKAQNGQDYSRSRADQQTAAANDEAKAKLANTAPVAKAPAATAAQLPQTGEKDAKPGILAGILSLLAGVSLFGFSFEKRKQEK
>NC_008529.1|WP_011678662.1|1753553_1754957_-|class-II-fumarate-hydratase
MAEQEYRIESDTIGEVKIPKEALWGPQTERSRNNFPSGELMPLAIIRAFLHLKKAAAESNVEVGDEPAEKGQAIEEAIDQLLALSDEDLRKNFPLHVLQTGSGTQTNMNVNEVVANLANKLHPGLNILPNDDVNRGQSSNDTYPTAMNIVAVEAVDKLEPAIEHLIDELKVKQDKYWKTVKVGRTHLQDATPLTFGQEVSGYISALKHDLAYIQELKPSLYELAIGGTAVGTGLNAAPGMTEAIAGKLSEVYGHEFKVDTNKFWGLAHHSALSVMHGAFKTLANDMFKIAQDIRFLASGPRAGYGELNIPANEPGSSIMPGKVNPTQAEAVTMAVARVLGNDVTINFAASQGNFEMNVFKTVMIAAFLESADILAGTITGFADKMIHGLTVNEQRMDDLLENSLMTVTALSPKIGYHEAAVIAQTAQREGTTLKEAALKSGKVTEEQYDEWMDYMAMTNIDRTKPEE
>NC_008529.1|WP_003620469.1|1766612_1768703_+|ATP-dependent-Clp-protease-ATP-binding-subunit
MDYNNFNDMDDLFRELMNGLGGFNSENRRYLINGRQVTPEEFAEYQKTGQLPGHGQAKNFQGKQKKANGILEKLGRNLTAEAREGKLDPVIGRNKEIQETAEILSRRIKNNPVLVGDAGVGKTAVVEGLAQAIVHGDVPEAIKNKEIISIDISSLEAGTQYRGSFEQNIQDLVKEVKDRGNVILFFDEIHQILGAGGMGDGNGSKGMSDILKPALSRGEITVIGATTQDEYRNTIMKDAALARRFNEVTVNAPSQADTFKILMGIRSLYEKHHNVELPDDVLKAAIDYSVQYIPQRSLPDKAIDLLDMTAAHLAAQHPVTDAKTIEKQIKEEKQAQKKAAENEDYQAALDHKTKAEKLEKQLSENHEERKTVATPADVAAAVERLTGIPVSKMGASDIERLKGLSSRLKGKIIGQDEAVEAVAKAIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDMFGSKDAIIRLDMSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTEKVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNTIIIATSNAGFGNEQLMGDAKKDEKLMDRLAPYFRPEFLNRFNAVIEFSHLTKEDLKEIVNLMLADVNKTLAKKGISLTVSESAKDYLIEQGYDEAMGARPLRRVIEQEIRDKVTDYYLDHLDVKKLKADMVDGALVISEDK
>NC_008529.1|WP_155589469.1|1768921_1769095_-|hypothetical-protein
MDVEADHFWQSQAVVVQKVLVSPQEVPLSVLPEDAQLDLVGDGIPEVFRLDLPATWY
>NC_008529.1|WP_080504252.1|1769266_1769803_+|GGDEF-domain-containing-protein
MPASKSQPPGKRGRTARDDLTSLKNRHNFARDFNYLTGKPILAMMLDVDHFKKFNDNFGHRYGDEVLKKISQALLKIYGIGHCYRYGGDEFLVLRDFTDTDTVAEKDRQFRKELEHARVLDLYMNITVSAGYAYGIANNSDEIKSMIRLADHNLYQVKKNGRKDICGSPFQPNFFEYE
>NC_008529.1|WP_011678669.1|1770191_1771073_-|transposase
MSSLPSFDTKNEPQISRSVEKFFKDYKVMELLRRCGLRKSKGIPLWSVLSYIFSNVFRDRSMYMQQKSGKCTAGFSKNTYYRFMQNPHINWLRLTILLAERIVNGHLKDLTYDQRADCFVFDDSLYSKTGYKKTELTAKVFDHVSMTYKKGFRMMTMGWTDGSSFVPIASSLLSSKNDQNVIGTTKKIDKRTIKGDHVVIQLLDQALKAGLTAKYVMFDTWFSNRLVPSVLPASPSSTLSWLPWAPAACTTSNCLKTAGLLLPKSPTTTWTLSGKPSWRPWLPSPACSRPSAW
>NC_008529.1|WP_011678670.1|1772322_1775511_-|carbamoyl-phosphate-synthase-large-subunit
MPKRTDIHKIMVIGSGPIIIGQAAEFDYSGTQACLALRDEGYEVVLVNSNPATIMTDTTIADKVYIEPLTVDSVSRIIRQEYPDAILPTLGGQVGLNMALALAKTGILDELHIELLGTKLASIEQAEDREKFKELCQKLGEPVPPSKTVKIVEDALAFGDEIGYPIIVRPAFTMGGTGGGICHNHDELAEIAKNGLELSPVTECLIEKSIAGYKEIEFEVMRDSSDNAMIVCCMENFDPVGIHTGDSIVFSPSQTLSDKEYQMLRDCSLKLIRALKIEGGCNVQLALDPNSLDYDVIEVNPRVSRSSALASKATGYPIAKMAAKIAIGMTLDEIKNPVTGTTYAEFEPALDYVVCKIPRFPFDKFPKADRVLGTQMKATGEVMAIGRTAEEAMQKAVQSLEIDEKDLYSAKAHKASDDEIEQKLVRPQDDRLFYLAEAFRRGYSLEDVHELTKINFYFLDVVKHMVEMEKEIEANPDDLDVLRLAKKYGFSDQTIAKLWHEYPDQVRDLRKANGIVPVYKMVDTCAAEFESTTPYFYSTYDGENESRKSGKKSVIVIGSGPIRIGQGVEFDYATVHSVKALQKMGYEAIVINSNPETVSTDFSVSDKLYFEPLTLEDVLNVCDLEQPEGVIVQFGGQTSINLAAGLERHGVKILGTTVKDLDRAEDREEFDQIIKSLHLHQPQGLTATTHEGVMKAADQLGYPVLVRPSYVLGGKAMEIVYSKDELEEYLHDHADIAEDHPILVDDYLDGRECDVDAISDGKTVLLPGIMEHIEHAGVHSGDSMAVYPPQTFSDEVEEKITDVTKKLALALNCKGIMNIQFIVRDGDVYVIEVNPRASRTVPFLSKITGIEMAQVATRVIMGESLEQQGYADGLAPEPEMISVKAPVFSFSKLADVDSYLGPEMKSTGEVMGSDHTFAKALYKAFAGAKMQLPENGNVLLTIEDRDKEKILPIAKRFARIGYRIFATKGTANFLKKNDLHVELVTKVHEDEQADDNILNELRDGKIDLVINTMGHDIEKNSDGFIIRQMAIQQNVPLLTALDTADALLKSLENRSFATDALK
>NC_008529.1|WP_011678671.1|1775503_1776589_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MRYLILEDGSIYAGEGFGSDRETTGEVVFTTGMTGYQEAITDQSYADQILVFTNPLIGNYGITLADYESLQPQIKGVICHQIARHPDNWRMQTTLPEFLEQLHIPGIQGIDTRELVKKLRVHGTLRGKIANSKENAEKIVQELKHKNVTQGVISRVSTKSAYPVPGSKRNIVVIDFGIKHSILRELAERDCNCIVLPYTATAEEVLNLHPDGVLLSNGPGDPEEMIEATKMVQEVEKHVPLFGICMGHQVFALANGAKTYKMKFGHRGFNHPVREIATGHIGFTSQNHGYAVDTKSIDKDNLMITHEEVNDGTVEGLRHKKYPAFSVQFHPDATPGPHDEDSLFDDFMSMIDQRKEEERHA
>NC_008529.1|WP_011678672.1|1776588_1777866_-|dihydroorotase
MQTVIKNGTVYQNGRLIHADVLIEDQKIKAIGTDLTGDKVIDATGKLVSPGLVDVHVHYRDPGQTYKEDIETGSKAAAHGGFTTVGAMPNVTPVPDTPDLMKKMVQENKQKGIVHIFQYGPITKNETTDELPDYAALKKAGAFALSNDGHGVQTAQTMYLAMQEAKKNDLIVAAHAQDDSLFNHGIVNEGEKAKELNLPPVTELAETTQIARDLLLAEKTGVHYHICHVSTKTSVELVRIAKACGINVTCEAAPHHLLLTEDDIPKDNGYYKMNPPLRSKEDQVALLVGLLDGTIDLIATDHAPHAKQEKQGGMQNAAFGITGSETAFSTLYTKFVKEDKVFTLEQLLSWLSDQPAKVFGLKKAGVLEPGCPADVAIFDLEHETELKEKNYQSKGINTPFTGQKIYGATVMTMVDGEVVYQRGEK
>NC_008529.1|WP_011678673.1|1777865_1778822_-|aspartate-carbamoyltransferase-catalytic-subunit
MKKLNLVALPHFVSVENLKNDEVKALIKRAEYFKKGGAVARLTSPVYVTNMFFEDSSRTHTSFEMAERKLGLTVIPFDPAHSSVNKGETLYDTSLVMNALGIDLEVIRHSQNEYYEDLINLKQHQKLNIGVINAGDGSGQHPSQCMLDMMTIHEHFGHFKGLKVAIVGDITNSRVAKSDMELLTKLGAEVYFSGPECWYSEEFDQYGKHEELDKLIPKMDVMMLLRVQHERHSGDPNEKKFDAHRYHEKYGINHKRYEAMKKDAIIMHPGPINHDVELSGDLVESDKCMFVRQMENGVFMRMAMLEAVLRGRKLGGLE
>NC_008529.1|WP_003621085.1|1778966_1779509_-|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR
MAKEIWDALAIKRALTRITYEIIEQNKGTDDLVLVGIKTRGVHLANRIHDRIQKLEGVDVPVGELDITLYRDDRHDALLKQDPVVNSDNVGVDINNKRVVLIDDVIYTGRTIRAAMDALMHVGRPSLIKVAVLVDRGHRELPIRADFVGKNIPTSADEQVAVNVVEKDGKDSVELKALPK
>NC_008529.1|WP_011678674.1|1779667_1780591_-|dihydroorotate-dehydrogenase
MVNTHVNLPGLDLKNPVMPASGTFGFGDVPAAQKFDLNDLGAMVIKTTTPHATTGNPQPQIAILEDGVLNSVGLTNPGVDQVISEKLTKLRHQYIDLPIMASVGGDSEDDYVEVAKKLSASGLVNALEINVSCPNVAQGGMSFGVHAGVVEELTKKIKMAVALPIYVKLTPNVTDIVEIAKAAESGGADGISMINTVLGMRIDVKTRKPLLGHNMGGLSGEAVKPIAIRMISQVRQVTQLPIIGMGGISTAQDVIEFILAGANAVAVGSAHFEDELAAKHIAENLPAELEKLGIEDINDLVGQVKFN

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_008529_2	2.20\|757407\|33\|NC_008529\|PILER-CR	757407-757439	33	NC_008529.1	478853-478885	2	0.939
NC_008529_2	2.28\|757403\|33\|NC_008529\|CRISPRCasFinder,CRT	757403-757435	33	NC_008529.1	478853-478885	2	0.939

1. spacer 2.20|757407|33|NC_008529|PILER-CR matches to position: 478853-478885, mismatch: 2, identity: 0.939

agtccacgtgcgtttgaagaacagcctgcctgt	CRISPR spacer
agtccacgtgcgtttgaaggacagtctgcctgt	Protospacer
*******************.****.********

2. spacer 2.28|757403|33|NC_008529|CRISPRCasFinder,CRT matches to position: 478853-478885, mismatch: 2, identity: 0.939

agtccacgtgcgtttgaagaacagcctgcctgt	CRISPR spacer
agtccacgtgcgtttgaaggacagtctgcctgt	Protospacer
*******************.****.********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_008529_2	2.1\|756243\|33\|NC_008529\|PILER-CR,CRISPRCasFinder,CRT	756243-756275	33	EF455602	Lactobacillus phage LL-H, complete genome	3989-4021	0	1.0
NC_008529_2	2.17\|757224\|33\|NC_008529\|PILER-CR	757224-757256	33	NC_001670	Lactobacillus delbrueckii plasmid pWS58, complete sequence	5278-5310	0	1.0
NC_008529_2	2.25\|757220\|33\|NC_008529\|CRISPRCasFinder,CRT	757220-757252	33	NC_001670	Lactobacillus delbrueckii plasmid pWS58, complete sequence	5278-5310	0	1.0
NC_008529_2	2.1\|756243\|33\|NC_008529\|PILER-CR,CRISPRCasFinder,CRT	756243-756275	33	NC_022775	Lactobacillus phage phiJB, complete genome	21458-21490	3	0.909
NC_008529_2	2.14\|757041\|33\|NC_008529\|PILER-CR	757041-757073	33	L02497	Bacteriophage mv4 ORF1, 3' end; minor structural protein (g20) gene, complete cds; major capsid protein (g34) gene, complete cds; ORF4-5, complete cds; ORF6, 5' end	1467-1499	4	0.879
NC_008529_2	2.22\|757037\|33\|NC_008529\|CRISPRCasFinder,CRT	757037-757069	33	L02497	Bacteriophage mv4 ORF1, 3' end; minor structural protein (g20) gene, complete cds; major capsid protein (g34) gene, complete cds; ORF4-5, complete cds; ORF6, 5' end	1467-1499	4	0.879
NC_008529_2	2.1\|756243\|33\|NC_008529\|PILER-CR,CRISPRCasFinder,CRT	756243-756275	33	NZ_CP024423	Paracoccus yeei strain TT13 plasmid pTT13-1, complete sequence	246588-246620	7	0.788
NC_008529_2	2.12\|756914\|33\|NC_008529\|PILER-CR,CRISPRCasFinder,CRT	756914-756946	33	NZ_CP028969	Aminobacter sp. MSH1 plasmid pUSP1, complete sequence	44283-44315	7	0.788
NC_008529_2	2.12\|756914\|33\|NC_008529\|PILER-CR,CRISPRCasFinder,CRT	756914-756946	33	NZ_CP026266	Aminobacter sp. MSH1 plasmid pAM01, complete sequence	41583-41615	7	0.788
NC_008529_2	2.3\|756365\|33\|NC_008529\|PILER-CR,CRISPRCasFinder,CRT	756365-756397	33	NZ_CP010578	Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB232, complete sequence	146039-146071	8	0.758
NC_008529_2	2.3\|756365\|33\|NC_008529\|PILER-CR,CRISPRCasFinder,CRT	756365-756397	33	NZ_CP010579	Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB92, complete sequence	19718-19750	8	0.758
NC_008529_2	2.11\|756853\|33\|NC_008529\|PILER-CR,CRISPRCasFinder,CRT	756853-756885	33	NZ_CP022999	Rhizobium sp. 11515TR strain 10195 plasmid p11515TR-A, complete sequence	828105-828137	9	0.727
NC_008529_2	2.12\|756914\|33\|NC_008529\|PILER-CR,CRISPRCasFinder,CRT	756914-756946	33	NC_023283	Streptomyces sp. FR1 plasmid pFRL3, complete sequence	182148-182180	10	0.697
NC_008529_2	2.12\|756914\|33\|NC_008529\|PILER-CR,CRISPRCasFinder,CRT	756914-756946	33	NC_023284	Streptomyces sp. F2 plasmid pFRL4, complete sequence	218776-218808	10	0.697

1. spacer 2.1|756243|33|NC_008529|PILER-CR,CRISPRCasFinder,CRT matches to EF455602 (Lactobacillus phage LL-H, complete genome) position: , mismatch: 0, identity: 1.0

cgttgaccgattgcagttcgtgcttttgcgtgt	CRISPR spacer
cgttgaccgattgcagttcgtgcttttgcgtgt	Protospacer
*********************************

2. spacer 2.17|757224|33|NC_008529|PILER-CR matches to NC_001670 (Lactobacillus delbrueckii plasmid pWS58, complete sequence) position: , mismatch: 0, identity: 1.0

tgcgattagcaagatctgtaaatcatgttttcg	CRISPR spacer
tgcgattagcaagatctgtaaatcatgttttcg	Protospacer
*********************************

3. spacer 2.25|757220|33|NC_008529|CRISPRCasFinder,CRT matches to NC_001670 (Lactobacillus delbrueckii plasmid pWS58, complete sequence) position: , mismatch: 0, identity: 1.0

tgcgattagcaagatctgtaaatcatgttttcg	CRISPR spacer
tgcgattagcaagatctgtaaatcatgttttcg	Protospacer
*********************************

4. spacer 2.1|756243|33|NC_008529|PILER-CR,CRISPRCasFinder,CRT matches to NC_022775 (Lactobacillus phage phiJB, complete genome) position: , mismatch: 3, identity: 0.909

cgttgaccgattgcagttcgtgcttttgcgtgt	CRISPR spacer
cgttgaccgactgcatttcgtgcttttgcgtct	Protospacer
**********.**** *************** *

5. spacer 2.14|757041|33|NC_008529|PILER-CR matches to L02497 (Bacteriophage mv4 ORF1, 3' end; minor structural protein (g20) gene, complete cds; major capsid protein (g34) gene, complete cds; ORF4-5, complete cds; ORF6, 5' end) position: , mismatch: 4, identity: 0.879

cgagatcccaggtggctttgtgatgtttgtttc	CRISPR spacer
tgaagttccaggtggctttgtgatgtttgtttc	Protospacer
.**..*.**************************

6. spacer 2.22|757037|33|NC_008529|CRISPRCasFinder,CRT matches to L02497 (Bacteriophage mv4 ORF1, 3' end; minor structural protein (g20) gene, complete cds; major capsid protein (g34) gene, complete cds; ORF4-5, complete cds; ORF6, 5' end) position: , mismatch: 4, identity: 0.879

cgagatcccaggtggctttgtgatgtttgtttc	CRISPR spacer
tgaagttccaggtggctttgtgatgtttgtttc	Protospacer
.**..*.**************************

7. spacer 2.1|756243|33|NC_008529|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024423 (Paracoccus yeei strain TT13 plasmid pTT13-1, complete sequence) position: , mismatch: 7, identity: 0.788

cgttgaccgattgcagttcgtgcttttgcgtgt	CRISPR spacer
cgttgaccgattgcagttcctccttcgaggttt	Protospacer
******************* * ***. . ** *

8. spacer 2.12|756914|33|NC_008529|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028969 (Aminobacter sp. MSH1 plasmid pUSP1, complete sequence) position: , mismatch: 7, identity: 0.788

cctccgcgtagaccgggatcttctcgccttcaa	CRISPR spacer
gctcgagggagaccgggaccttctcgcgttcaa	Protospacer
 *** . * *********.******** *****

9. spacer 2.12|756914|33|NC_008529|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026266 (Aminobacter sp. MSH1 plasmid pAM01, complete sequence) position: , mismatch: 7, identity: 0.788

cctccgcgtagaccgggatcttctcgccttcaa	CRISPR spacer
gctcgagggagaccgggaccttctcgcgttcaa	Protospacer
 *** . * *********.******** *****

10. spacer 2.3|756365|33|NC_008529|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP010578 (Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB232, complete sequence) position: , mismatch: 8, identity: 0.758

gccggccggtttgtccaaaaaggctctaaaggg	CRISPR spacer
tatgggctatttttccaaaaacgctctaaaggg	Protospacer
  .** * .*** ******** ***********

11. spacer 2.3|756365|33|NC_008529|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP010579 (Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB92, complete sequence) position: , mismatch: 8, identity: 0.758

gccggccggtttgtccaaaaaggctctaaaggg	CRISPR spacer
tatgggctatttttccaaaaacgctctaaaggg	Protospacer
  .** * .*** ******** ***********

12. spacer 2.11|756853|33|NC_008529|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022999 (Rhizobium sp. 11515TR strain 10195 plasmid p11515TR-A, complete sequence) position: , mismatch: 9, identity: 0.727

cgtgtgttaaaacgccgtcgatttcttcttcgg	CRISPR spacer
ttcggcctacatcgccgtcgatttcttcttcgt	Protospacer
. .*  .** * ********************

13. spacer 2.12|756914|33|NC_008529|PILER-CR,CRISPRCasFinder,CRT matches to NC_023283 (Streptomyces sp. FR1 plasmid pFRL3, complete sequence) position: , mismatch: 10, identity: 0.697

cctccgcgtagaccgggatcttctcgccttcaa	CRISPR spacer
cgctcgcgtcgaccgggatcttctcaccggggc	Protospacer
* ..***** ***************.**   .

14. spacer 2.12|756914|33|NC_008529|PILER-CR,CRISPRCasFinder,CRT matches to NC_023284 (Streptomyces sp. F2 plasmid pFRL4, complete sequence) position: , mismatch: 10, identity: 0.697

cctccgcgtagaccgggatcttctcgccttcaa	CRISPR spacer
cgctcgcgtcgaccgggatcttctcaccggggc	Protospacer
* ..***** ***************.**   .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

238763 : 247502

Staphylococcus_virus(14.29%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003619456.1\|238763_239756_+	GMP reductase	Q4ZCY7	Staphylococcus_virus	1.8e-132	68.4
WP_011677980.1\|239884_241192_+	Y-family DNA polymerase	M1Q231	Streptococcus_phage	1.1e-86	40.6
WP_003619451.1\|241184_241544_+	hypothetical protein	E3W8I0	Leuconostoc_phage	7.8e-06	34.8
WP_011677981.1\|241613_242906_-	purine permease	Q9KX94	Enterobacteria_phage	3.7e-29	30.6
WP_003619447.1\|242935_243505_-	xanthine phosphoribosyltransferase	NA	NA	NA	NA
WP_003619444.1\|243859_245017_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	4.1e-56	31.3
WP_003619442.1\|245016_246570_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	3.5e-18	30.2
WP_003616790.1\|246892_247144_+	type II toxin-antitoxin system HicA family toxin	NA	NA	NA	NA
WP_003616793.1\|247130_247502_+	type II toxin-antitoxin system HicB family antitoxin	A0A0K2CZV4	Paenibacillus_phage	8.9e-21	45.6

DBSCAN-SWA_2

1090394 : 1103776

Erwinia_phage(12.5%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011678371.1\|1090394_1091789_-\|protease	ATP-dependent protease ATPase subunit HslU	A0A1B2IB03	Erwinia_phage	1.1e-31	26.2
WP_003618695.1\|1091791_1092325_-\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_003618694.1\|1092433_1093321_-	tyrosine recombinase XerC	S5W9T9	Leptospira_phage	1.4e-24	30.2
WP_011678372.1\|1093320_1094640_-\|tRNA	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	NA	NA	NA	NA
WP_011678373.1\|1094771_1096949_-	type I DNA topoisomerase	A0A1V0SCS0	Indivirus	2.7e-93	34.8
WP_011678374.1\|1097075_1097915_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	9.1e-29	36.9
WP_011678375.1\|1098011_1098782_-	ribonuclease HII	G9E3X7	Emiliania_huxleyi_virus	3.3e-25	37.2
WP_003623895.1\|1098771_1099629_-	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_002880201.1\|1099703_1099934_-	YozE family protein	NA	NA	NA	NA
WP_011543974.1\|1099937_1100783_-	DegV family protein	A0A0N9SI50	Staphylococcus_phage	1.0e-19	45.0
WP_011678376.1\|1100917_1101580_+	hemolysin III family protein	NA	NA	NA	NA
WP_011678377.1\|1101605_1102796_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	1.6e-42	47.3
WP_003618684.1\|1102876_1103776_+	YitT family protein	M1Q1P6	Streptococcus_phage	1.8e-51	39.8

DBSCAN-SWA_3

1691702 : 1698538

Streptomyces_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011678633.1\|1691702_1692482_-	C40 family peptidase	A0A1V0DZX6	Clostridioides_phage	4.1e-07	36.1
WP_011678634.1\|1692527_1693286_-	C40 family peptidase	A0A0A8WF62	Clostridium_phage	8.8e-15	40.2
WP_011678636.1\|1694442_1695225_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	1.0e-13	42.7
WP_014565355.1\|1695412_1695886_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	4.2e-15	42.7
WP_011678637.1\|1696055_1697102_-	lactate dehydrogenase	M1H502	Paramecium_bursaria_Chlorella_virus	1.2e-27	29.7
WP_035170188.1\|1697385_1697871_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	2.5e-15	40.4
WP_011678638.1\|1697995_1698538_-	AAA family ATPase	U5J9X2	Bacillus_phage	1.7e-12	35.4

DBSCAN-SWA_4

1818807 : 1826892

Lactobacillus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011678688.1\|1818807_1819899_+	BMP family ABC transporter substrate-binding protein	A0A0A7DN02	Lactobacillus_phage	7.8e-81	47.1
WP_011678689.1\|1819948_1820383_-	hypothetical protein	NA	NA	NA	NA
WP_011544342.1\|1820425_1820836_-	hypothetical protein	NA	NA	NA	NA
WP_011678690.1\|1820878_1821919_+	protein kinase	A0A2I2L4J2	Orpheovirus	2.9e-08	32.1
WP_011678691.1\|1822013_1822610_+	DUF4352 domain-containing protein	A0A0P0IXE0	Lactobacillus_phage	1.9e-44	69.2
WP_011544345.1\|1822796_1823894_+	BMP family ABC transporter substrate-binding protein	A0A0A7DN02	Lactobacillus_phage	1.0e-80	46.3
WP_003623370.1\|1824174_1825260_+	BMP family protein	A0A0A7DN02	Lactobacillus_phage	9.5e-79	48.6
WP_003621701.1\|1825347_1826892_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.6e-13	26.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_008529

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection