CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_008578	Acidothermus cellulolyticus 11B, complete sequence	18 crisprs	cas4,DinG,cas3,cas2,cas1,cas9	1	22	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_008578_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_1

40612-40728

Orphan

Consensus_repeat	Method
GGCAATCCGCGGATGAGGCGTCCGGGCGGCGGTGCCGGCTGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_1

>merge|NC_008578|1|40612-40728|CRISPRCasFinder
GGCAATCCGCGGATGAGGCGTCCGGGCGGCGGTGCCGGCTGGGCGGTCGTGCCGGCCGGGCGCCCGCGGCGTATGGCAATCCGCGGATGAAGCGTCCGGGCGGCGGTGCCGGCTGGG

>NC_008578|1|1|40612-40728|CRISPRCasFinder
GGCAATCCGCGGATGAGGCGTCCGGGCGGCGGTGCCGGCTGGG	CGGTCGTGCCGGCCGGGCGCCCGCGGCGTAT
GGCAATCCGCGGATGAAGCGTCCGGGCGGCGGTGCCGGCTGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_083760601.1\|39358_40519_-\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|179559
NC_008578.1\|WP_083760413.1\|36915_38148_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NC_008578.1\|WP_011718879.1\|44328_44760_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319899
NC_008578.1\|WP_011718866.1\|26836_29221_-\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319844
NC_008578.1\|WP_041834836.1\|38618_38894_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011718882.1\|47539_48028_+\|OsmC-family-protein	unknown	unknown	gnl\|CDD\|376823
NC_008578.1\|WP_011718871.1\|34266_35907_-\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NC_008578.1\|WP_148204480.1\|42852_43662_-\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011718881.1\|45634_47398_+\|chloride-channel-protein	unknown	unknown	gnl\|CDD\|238233
NC_008578.1\|WP_083760417.1\|49465_50989_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NC_008578.1\|WP_011718869.1\|31757_33425_+\|glycerol-3-phosphate-dehydrogenase/oxidase	unknown	unknown	gnl\|CDD\|223651
NC_008578.1\|WP_011718872.1\|35931_36915_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NC_008578.1\|WP_011718868.1\|30611_31544_-\|PAC2-family-protein	unknown	unknown	gnl\|CDD\|378251
NC_008578.1\|WP_083760602.1\|51536_52460_-\|fructosamine-kinase-family-protein	unknown	unknown	gnl\|CDD\|225547
NC_008578.1\|WP_011718883.1\|48158_49064_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_008578.1\|WP_011718870.1\|33417_34236_-\|carbon-nitrogen-family-hydrolase	unknown	unknown	gnl\|CDD\|143607
NC_008578.1\|WP_011718886.1\|51103_51544_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011718876.1\|41318_42296_+\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|377369
NC_008578.1\|WP_041835124.1\|29817_30390_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226765
NC_008578.1\|WP_011718880.1\|44860_45496_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_083760601.1\|39358_40519_-\|histidinol-phosphate-transaminase	gnl\|CDD\|179559	PRK03321, PRK03321, putative aminotransferase; Provisional.	0
NC_008578.1\|WP_083760413.1\|36915_38148_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	8.14856e-166
NC_008578.1\|WP_011718879.1\|44328_44760_+\|VOC-family-protein	gnl\|CDD\|319899	cd06588, PhnB_like, Escherichia coli PhnB and similar proteins. The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.	5.48849e-38
NC_008578.1\|WP_011718866.1\|26836_29221_-\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|319844	cd07544, P-type_ATPase_HM, P-type heavy metal-transporting ATPase; uncharacterized subfamily. Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_008578.1\|WP_011718882.1\|47539_48028_+\|OsmC-family-protein	gnl\|CDD\|376823	pfam02566, OsmC, OsmC-like protein. Osmotically inducible protein C (OsmC) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation.	7.17674e-14
NC_008578.1\|WP_011718871.1\|34266_35907_-\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	4.50502e-120
NC_008578.1\|WP_011718881.1\|45634_47398_+\|chloride-channel-protein	gnl\|CDD\|238233	cd00400, Voltage_gated_ClC, CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This domain is found in the halogen ions (Cl-, Br- and I-) transport proteins of the ClC family. The ClC channels are found in all three kingdoms of life and perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, transepithelial transport in animals, and the extreme acid resistance response in eubacteria. They lack any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. Unlike cation-selective ion channels, which form oligomers containing a single pore along the axis of symmetry, the ClC channels form two-pore homodimers with one pore per subunit without axial symmetry. Although lacking the typical voltage-sensor found in cation channels, all studied ClC channels are gated (opened and closed) by transmembrane voltage. The gating is conferred by the permeating ion itself, acting as the gating charge. In addition, eukaryotic and some prokaryotic ClC channels have two additional C-terminal CBS (cystathionine beta synthase) domains of putative regulatory function.	1.62034e-112
NC_008578.1\|WP_083760417.1\|49465_50989_+\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.80679e-100
NC_008578.1\|WP_011718869.1\|31757_33425_+\|glycerol-3-phosphate-dehydrogenase/oxidase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	1.00788e-119
NC_008578.1\|WP_011718872.1\|35931_36915_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	3.09847e-158
NC_008578.1\|WP_011718868.1\|30611_31544_-\|PAC2-family-protein	gnl\|CDD\|378251	pfam09754, PAC2, PAC2 family. This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits.	4.6761e-48
NC_008578.1\|WP_083760602.1\|51536_52460_-\|fructosamine-kinase-family-protein	gnl\|CDD\|225547	COG3001, COG3001, Uncharacterized protein conserved in bacteria [Function unknown].	1.41925e-62
NC_008578.1\|WP_011718883.1\|48158_49064_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	3.79362e-20
NC_008578.1\|WP_011718870.1\|33417_34236_-\|carbon-nitrogen-family-hydrolase	gnl\|CDD\|143607	cd07583, nitrilase_5, Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	6.62982e-118
NC_008578.1\|WP_011718876.1\|41318_42296_+\|restriction-endonuclease	gnl\|CDD\|377369	pfam04471, Mrr_cat, Restriction endonuclease. Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA.	6.20752e-36
NC_008578.1\|WP_041835124.1\|29817_30390_-\|hypothetical-protein	gnl\|CDD\|226765	COG4315, COG4315, Uncharacterized protein conserved in bacteria [Function unknown].	1.99004e-21
NC_008578.1\|WP_011718880.1\|44860_45496_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.55271e-07

>NC_008578.1|WP_083760601.1|39358_40519_-|histidinol-phosphate-transaminase
MSDSAPRPGARPFPRADLRGIPTYKPGRRPATGRRAYKLSSNESPYPPLPSVLDAIAQASDTIHRYPDLLSSDLVAAIAHRFGVPESHVVVGCGSVGLATQIVQAFAGPGDEVAYAWRSFEAYPIIVQVAGAVSIQIPLRPDGVHDLPRLAASITPKTRVVFICNPNNPTGTVVGADALLRFLDAVPAGCLVVLDEAYREFVTNPDSPDGITLYRDRPNVVVLRTFSKAYGLAGLRVGYAIAQPEIVDSIRITDVPFSTNALGQAAALASLQPAAEAELMARVQATVSERERIVAALRAAGWDIPQPEGNFVWLPTGDRTESFAAACEAAGVIVRPFAGEGVRVTIGEPEANNLFLDVARAHGPAPTAPTAHGAAQPSPSGPDEPA
>NC_008578.1|WP_041834836.1|38618_38894_+|hypothetical-protein
MTDGGAGDGVGVADEPPIGKLISCVPGVGRLGTLGGAGVGVSAGRASGRDGDGVGTADGVCGGGFPLFGAAVVVGLRGITTTGLGALLPTG
>NC_008578.1|WP_083760413.1|36915_38148_-|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MATPTRRQRWSRCPCPPGDTGARRTRETLASCRQRSVIVTVDSLHHTVAPAEAGPADPTLVQLLTPEGQRRGHPDFPLEIADDDVRALYRDMVALRRFDVEATTLQRQGELGIWAQVLGQEAAQIGSARALRPTDMVFPTYREHGVAWCRGIPPEDILQLFRGINFGGWDPAAYHVAPYTIVIGAHALHAVGYAMALQREPGNDSIAIAYFGDGATSEGDVNEAFVFAASYRAPVIFFVQNNQWAISVPEIRQSPIPLYQRAAGFGFPGVRVDGNDVLACLAVTRAAAAHVRAGNGPYLIEAFTYRMGAHTTSDDPTRYRLAAEVEAWKLRDPIERVKAYLSRSGAADADFFTDVDTEAERLAERVRAACVTMPDPGPLTMFDHVYAAGSAMLDAEKAAYAEYLASFEEA
>NC_008578.1|WP_011718872.1|35931_36915_-|alpha-ketoacid-dehydrogenase-subunit-beta
MAALALARALNLGLRKALEANPKVVIMGEDVGKLGGVFRVTDGLQKDFGEDRVMDTPLAESGIVGTAIGMALRGWRPVCEIQFDGFVFPAYDQIVNQLAKLHYRSGGRLRVPLVIRIPFGGGIGAVEHHSESPEALFAHIPGLKVVACSNAADAYTMIQQAVACDDPVIFFEPKRRYWERGDVDLDIPLEDAFPLHAARVVREGRDATLLAYGPSVRLALDAAAAAAEDGRELEVIDIRSLSPLDWETVHHSVRRTGRCVVIHEAPVFVGYGAELAARVTEQCFYSLEAPVLRVGGFSIPYPPSRLEEHYLPDVERVLDAVDRVFAY
>NC_008578.1|WP_011718871.1|34266_35907_-|2-oxo-acid-dehydrogenase-subunit-E2
MIDIRYFRLPDVGEGLTEAEITRWHVRPGDRVGQNQVIAEIETAKALVELPSPFAGIVAEILVAEGTTVPVGTPIIGIDVAAAQSGAHPGVRETPNANDEADSAAMPRESAVIAATGSGTVPATGSGTAAATEKSTAMAPEKSSDMPDASGGTERTAVLVGYGPRTEGTPHRRRRRVGKPERPAEPVQAVAAAFHSQQPEHIAVPAIDTVEETADEPPPRAVTTSPVSTARDRSVLTEPILAKPPVRKLARDLHVDLRGVQGSGPGGVITREDVEAAARTTATAARTTAGATLGESLAAAATAPDATRPPIMRGEERIPVRGVRRETAAAMVRSAFTIPHVTEFVTIDVTPSMETLDRLRNRPEFAGIKLSPLTLTAKAVLLALRRYPLVNSYWDDASDEIVVRHYVNLGIATATPRGLVVPNIKDADRLSLIDLARAINELAATAREGRTPLAQLRNGTFTITNVGVFGVDTGTPIINPGEAAILALGTVRRAPWLYHDAVQPRWVTTLGLSFDHRIIDGDLGSRFLRDVAAFLEDPGAALLAAV
>NC_008578.1|WP_011718870.1|33417_34236_-|carbon-nitrogen-family-hydrolase
MRITILQLEVSDHEPWPDRVDRVVDLVASCRDADLVVLPELWVPGAFASRFFAEVATELPGPIIPRLGAVAKELGAFIMAGTFIERADPATDRIGYNTAVLLNPDGAIAHTYRKVHLFGFHEGEARMLAAGNDVTTCRLEGGRMTETATYGTSTCYDLRFPELYRILVDQGCDLLVIPSGWPAQRLEHWRVLTRARAIENQLFVVACNETGHQQGVELAGHSVVVDPWGQVVAEAGAGEEILTVDIDLGEVPRIRRDFPVLPDRRFRCVPAN
>NC_008578.1|WP_011718869.1|31757_33425_+|glycerol-3-phosphate-dehydrogenase/oxidase
MGSRRSPVTRAAQVRRQLTRTTLQHGIFDVLVVGGGIIGLSTAWHAARSGLRVALVEAGDFAGATSSASTKLVHGGLRYLAMGDLRLVYENHTERRALGDELAPHLVRPLPFLVPLYEGGPYGRVRVGAGMLVYSALSKFDDGPGKLLSARRAAQMVPALRLDGLRGCGLYYDHQMNDARVALMVAHAASECGAVLANYSAVTGFLVENGRMSGACVVDRLDGTEYAVAARAVVNATGPWVDHVRRLEDPDAAPSVQLSKGAHLVVRLHAPADGEAPPWRAALTVPLADGRVSFAIPWEDQLLLGTTDEPYDGDPAAVQCTDADEARILSEAGQAIDPAWLAKVEVRYRFAGLRVLPRSEQDTQHIRRETVISRGRYGLVSVAGGKWTTFRRIGLDVLRQIAETLGGTAIDDHRMMLPGAAHPDAVARILRAAHPELPADVVAHLAGHYGTYAHEISRILTADPRLAERIHPDGPDIWAQVAYAVTDEWACTVDDILRRRTTVEVRGLATPEVHAEVERWLQRTGVNPMSRWLARWTRPWPSGRKAVRSAVRRVS
>NC_008578.1|WP_011718868.1|30611_31544_-|PAC2-family-protein
MLDPTDLYTISGTPPARAPDAPLILVHALSGYVDAGDAVRLTARHLLDTLDHREIARFDIDQLFDYRARRPPMLFDEDHWAAYDAPELVVHAVTDGGGREFLLLTGPEPDTQWERFVAAVCTLLERYGVDVTVGLNAIPLATPHTRPIGVTRHATSQDLIPGNRPWLQQVHVPASAAHLLEFRLGEQGRKAMGIAVHVPHYVAQSEFPPAALRLIDELRERTGLDLPREPIATAAAATLAEIDRQVGESTDAMAMVSTLEQQYDAFLHARSGESPLGGGTDNLPSADELAAELERFLAEQARRHRDDRDQ
>NC_008578.1|WP_041835124.1|29817_30390_-|hypothetical-protein
MRARRPIALAAVAFAALLTAGCSSSSYGGGSTASTSTAQAAGGGAASSGAASAGAASAGAAVVGTATGPLGTYLVDGRGMTLYLWDADRGTASTCYNACAKAWPPLLTNGAPTAAGGADASKLGVSKRTDGTTQVTYNGHPLYYFYKDTKPGEMAGQGSNGFGAPWWIVAPSGTPIITMPSSSGGYGYNY
>NC_008578.1|WP_011718866.1|26836_29221_-|heavy-metal-translocating-P-type-ATPase
MRREHWLFTTSTAFLALGGLAWLVHMHKAAVVLWVLATSLGLAVSLATTIKAVTKRRPTVDVIALLALAGALAVREPFAGAVIAVMLASGQLLEERASARASRTLSALVARSPQQARRYRTSGTTPAAGEAVDSDAEVIEEVPIDAVQVGDRVVVRPGEVVPVDGRLLTPGVFDESSLSGESREVEREAGEPIRSGVINIGSPVELAVTAPAAESTYARLVQLVAEAQRVATPFVRLADRLAVFFVPLTLAVAGSAWAFSGDAVRAVAVLVVATPCPLLLAVPIALISGVSRAAASGVVVKGAGALEKLARGRTILFDKTGTLTRGEPEIAEIIVADTSIDPRHLLRLAAAVEQFSAHVFAAAFARASGRSQLSVPVASDVAEIPGCGVVGVVDGREVRIGKAHWVLDGATPAWARRAQRRAEMDGSSVAFIAVDGRPAGAFLLRDPVRSDAPRMIRTLRKAGLTRIVLLTGDRPDVAESVGRVVGIDAVIADADPADKLVVVREESSVAPTIMVGDGINDAPALAAAGAGVALAGRGATASSEAADVVLVADRVDALADAVLTARRTKRIAGQAAGTGMGLSLAAMAAAGLGLLPPAAGALLQEGIDLLAIALALRALLPGTRHTVGLATADQAVAERLRAEHDVVRSVGQRLRVVADALAPCREDFSALEDLVGELEAVLLPHERAEEDQLLPIVARALRSSDVVAGLSRAHAEIEHYVRRLRRLLTMVGGEPESDDVIEARRLLYGLHAVLDLHNAEEDEIAFALLPDAGQRNTQDQKRVLTSTAPTGVSE
>NC_008578.1|WP_011718876.1|41318_42296_+|restriction-endonuclease
MAVVTIPQYHELMWPVLIALRKRGGSATIKEIYEQVVEDEHFSEEQQAVPTKDGRMSELEYRLHWARTHLKGIGAIQNSTRGVWSLTEKGQTITPEQMRRDTKAYRDELLRRAKQKQPSNSATDQASDDELDSWKEQLIARLLRLPPHGFERLAQRLLREAGFVYVTVLGTSGDGGIDGVGVYRLSPVSFPVYFQCKRYKGSVTAGVVRDFRGAMAGRGDKVLLITTGSFTKDAQNEASRDGAPPVELIDGDRLCDLLRDYRLGVDVRGVSSMRLSSMRRSSTSTTPPAPPRRRMPDTGASRFTNYGRGGTSERFIADRCRAVHD
>NC_008578.1|WP_148204480.1|42852_43662_-|hypothetical-protein
MDALEIEAARVVNSFYMGRIIQRDGMKASDGSHDYDIELPDGRIIALEVTSAADPERMALLSELSKTPSIPSSLEHDWLVSVWDVRNEPHVNIKRLVKKTEPRLSTLVRHGVTEIDKVSLDRKRHVPRDVCYELASLGVARARTLTLANPGEVREIFFSYAGGVTSHQGILNQLIEQTTKANAAKLAVANAAERHLFVWVTALGRPDVELAMFSNWLPVNSPAIAPGIDVVWAATLETPGFCQQRIRRLWRVRREGPWESLPLPFGIAD
>NC_008578.1|WP_011718879.1|44328_44760_+|VOC-family-protein
MARVSTYLNFQGQTEEAFTFYAGIFGTEISMLVRYADVPDMPLENLPAEERNLVMHAELPIMAGHMLMATDMLRSMGHETRVGNNTTLCLEVDSREDADHLYQALSAGGSEGSPMADMPWGSYWGVTLDRYGIRWMINYAYAS
>NC_008578.1|WP_011718880.1|44860_45496_-|TetR/AcrR-family-transcriptional-regulator
MPRSGPSRAPRTGHEVRRTRTPWGTISRETVVDAAIKAVTSGNYEDMSIRSLAADLGVAPMTLYRHVRDKDDLLDEVVDRLLARVWKPTVSRSDWRAWIIQAADKLRRFLVTSPVALYVYLRHPVVTPTAIRRMTAMLAVLRQGIGDEEKARRAYAVIHAYTLGFAALEVARSGWSSAETTVDEVTREVAAFISPRQFRDGLGYLLDGIAG
>NC_008578.1|WP_011718881.1|45634_47398_+|chloride-channel-protein
MNEVDSYAGRRDAESSWRAFGYRAFASAPLRLTSATANWLRSSRLGTVAVAFLVGTGAGLGAVGFRWLIFTVTWLVTGHKEFGQAGHIGSSHLPALGVWFLLLIPAVGGLLYGPLIQRFAPEARGHGVPEVMIAVAENGGRIRSQVTVVKALASALCIGTGGSVGREGPIVQIGSAFASSIGQIVRLPESRLRILVACGAAGGISATFNAPMTGVLFGFELILREFSIGALLPIIVSAVLADIVGRAFFGSGPILSQVPHYLVLPHDMDFILVGVLGLIAAVIGVGFKSALYRIEDVCDRVWGNRPEWARPAVGGIVLGVLLLALPQLYGVGYPVMDKAVAGQYALWFLLLLMVGKIVAASLTIGIGGSGGVFAPSLFIGATAGTAFGAVAEHLFGPQVGSPAIYGIIAMGAVFAAAARAPLTAIASVIEMTGNFTLTLPVMLAVGLAAGLSKRLTYGTIYTTKLLRRGIDIERPKSSSMLQVLTVADVMQPLTVLDGQGRLQPAGASGEADGRAAVDPSTTLRAGDRVLVLVPVPSRDASAKDGEEESHDDVRGATAEEDHVSAVPTLDAVDLPDGGRSDSHVVLR
>NC_008578.1|WP_011718882.1|47539_48028_+|OsmC-family-protein
MSQEHARTEGQGKATHVGLDLEHDYRFRVDFGAHHEPLVMDEPPPLGNNDGPNASAVLAAAVGNCLSASLLYCLRKARIEVDGMHTDVRVSLARNEAGRLRVSAIRVELQPRVTDETSGRVERCRQLFEDFCVVTESVRTGIDVEVIVSPESAAPPVAEPHP
>NC_008578.1|WP_011718883.1|48158_49064_+|alpha/beta-fold-hydrolase
MTSVFEVERVQVSAELRLAVRRLRGPRRPFLLVHGLASNARLWDGVAQHLAAAGHETVAVDLRGHGESDAPAARYDTATAAADVHELCRRMNLTGNRRPIAVGQSWGGNVVLTLAARHGGAAGLVLVDGGWLHLADRFPTFDDCWAALAPPQFDGVRFDDVRRHLAEMHPDWSPEARDAVLGNFRILEDGTVRARLERDHHRSILFSLWSENPRDLYPLVDVPVFVIPAIPPNFDPATDDEQLIEAKPGLYDALNMLADVDVRWYVGADHDLHAQYPERLAADLLAFATRVDSPERDATGR
>NC_008578.1|WP_083760417.1|49465_50989_+|MFS-transporter
MNSGRSARRRSPAHSPPFHRLIVPSFVPRTRLLPPSVARSPCPCGANHRRPPDGTSLRGHQATRHPPAGVPAAQPYVAEARHHQTAKGECVLRSADRSNSLLRQPRAVYAVAFACVISFMGIGLVDPILPALAAKLHATPSQVELLFTSYLVITAVAMLITGWVAGRLGSKNTLLVGLALVVIFSALAGASRTIGGIVGFRAGWGLGNALFIATSLAVIVASAAGGFGAAIILYETALGIGIASGPLLGGLLGNVSWRGPFFGVAVLMAAALVATLVLLPPTPRPAVRSRLRDPILALEHGPLARVSLTGLFYNWGFFTVLGYSPFLMHLSALDLGWVFFGWGVLVAIFAIIIAPMLRRRFGTAPTLYVNLALVAVGLLVIGGWAAHPLVIIVTVILFGSVVGINNTLVTTAVMSVAPVPRPVASAAYGFVRFIGGGLAPYVAGKLVEHVGVHVPFVIGAVVVLAGIVSLAGARDALDAADRSDAVPAAASAPVVAAPVGCLEPGES
>NC_008578.1|WP_011718886.1|51103_51544_+|hypothetical-protein
MNWRWSLRARDGGMTGLEFASAVTGGGHYRVLVHAAPAQLAVEVRHLDDDQLVARSDADRDGEYSPMTLLTIADGRVRRDEVWPTPEFYGLPVILAGGEVGVLRYWEHAADHSWWRWLIEFSNHKGWPPDWRPPELPPDALRPAIS
>NC_008578.1|WP_083760602.1|51536_52460_-|fructosamine-kinase-family-protein
MIERSCTALVDELERRLAGRSAAPTSPAERPVEAADAGLSVTLVSRVSGGDICESWRGADRHGRPVFVKTLRNAPAGFFTAEARGREFLAVPGGPPLPEILAVTEDALVVSWIEEDRPNPRAAREFGRRLARMHASAPPYFGAAEPGFIGTLPLPNEPTASWPEFYAKCRLRPFLQALPRRQRDVVEEVCDVIDRLAGPTEPPARIHGDLWSGNLVWAADGRVWLVDTAAAHGGHRETDLAMLALFGTPYFDDILAGYHEVAPLDPGWRRRLPLHQLHPLLVHATLFGGGYAERAVAAARTALEILS

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Crispr_ID: NC_008578_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_2

199670-199755

Orphan

Consensus_repeat	Method
GCCGCCAGCGCACCCGTCGAGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_2

>merge|NC_008578|2|199670-199755|CRISPRCasFinder
GCCGCCAGCGCACCCGTCGAGCGGATGTCCCGATCTTCGGGCAACTCGGGGCCGACAAGCTGGGCCTCCAGCGCACCCGTCGAGCG

>NC_008578|2|2|199670-199755|CRISPRCasFinder
GCCGCCAGCGCACCCGTCGAGCG	GATGTCCCGATCTTCGGGCAACTCGGGGCCGACAAGCTGG
GCCTCCAGCGCACCCGTCGAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_011719015.1\|184776_185601_+\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|238635
NC_008578.1\|WP_083760609.1\|198770_199442_-\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|379247
NC_008578.1\|WP_049751316.1\|185955_187062_+\|DUF348-domain-containing-protein	unknown	unknown	gnl\|CDD\|226111
NC_008578.1\|WP_011719018.1\|188339_190310_+\|PHB-depolymerase-family-esterase	unknown	unknown	gnl\|CDD\|273828
NC_008578.1\|WP_011719028.1\|202043_203336_+\|deferrochelatase/peroxidase-EfeB	unknown	unknown	gnl\|CDD\|273606
NC_008578.1\|WP_041834854.1\|193132_194065_+\|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase	unknown	unknown	gnl\|CDD\|235110
NC_008578.1\|WP_169303217.1\|190921_192937_+\|glycoside-hydrolase	unknown	unknown	gnl\|CDD\|366032
NC_008578.1\|WP_011719027.1\|200868_202026_+\|EfeM/EfeO-family-lipoprotein	unknown	unknown	gnl\|CDD\|271139
NC_008578.1\|WP_011719035.1\|208419_209907_+\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224787
NC_008578.1\|WP_011719029.1\|203506_204274_+\|metal-dependent-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224240
NC_008578.1\|WP_011719023.1\|196901_197843_+\|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223677
NC_008578.1\|WP_011719021.1\|194120_195044_-\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|132002
NC_008578.1\|WP_011719031.1\|205441_206167_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912
NC_008578.1\|WP_041834857.1\|210092_211385_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_008578.1\|WP_011719030.1\|204379_205369_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_008578.1\|WP_011719022.1\|195237_196191_-\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223528
NC_008578.1\|WP_011719017.1\|187182_188055_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NC_008578.1\|WP_041835184.1\|207471_208062_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_008578.1\|WP_011719026.1\|199955_200807_+\|FTR1-family-protein	unknown	unknown	gnl\|CDD\|251822
NC_008578.1\|WP_011719032.1\|206251_207448_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_011719015.1\|184776_185601_+\|TatD-family-hydrolase	gnl\|CDD\|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	5.15878e-107
NC_008578.1\|WP_083760609.1\|198770_199442_-\|M15-family-metallopeptidase	gnl\|CDD\|379247	pfam13539, Peptidase_M15_4, D-alanyl-D-alanine carboxypeptidase. This family resembles VanY, pfam02557, which is part of the peptidase M15 family.	5.83848e-20
NC_008578.1\|WP_049751316.1\|185955_187062_+\|DUF348-domain-containing-protein	gnl\|CDD\|226111	COG3583, COG3583, Uncharacterized protein conserved in bacteria [Function unknown].	2.22635e-55
NC_008578.1\|WP_011719018.1\|188339_190310_+\|PHB-depolymerase-family-esterase	gnl\|CDD\|273828	TIGR01840, poly3-hydroxybutyrate_depolymerase_A_precursor, esterase, PHB depolymerase family. This model describes a subfamily among lipases of the ab-hydrolase family. This subfamily includes bacterial depolymerases for poly(3-hydroxybutyrate) (PHB) and related polyhydroxyalkanoates (PHA), as well as acetyl xylan esterases, feruloyl esterases, and others from fungi. [Fatty acid and phospholipid metabolism, Degradation].	2.75243e-40
NC_008578.1\|WP_011719028.1\|202043_203336_+\|deferrochelatase/peroxidase-EfeB	gnl\|CDD\|273606	TIGR01412, Probable_deferrochelatase/peroxidase_EfeN, Tat-translocated enzyme. This model represents a small family of proteins with a typical Tat (twin-arginine translocation) signal sequence, suggesting that the family is exported in a folded state, perhaps with a bound redox cofactor. Members of this family show homology to Dyp, a dye-decolorizing peroxidase from Geotrichum candidum that lacks any typical heme-binding site.	3.16572e-158
NC_008578.1\|WP_041834854.1\|193132_194065_+\|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase	gnl\|CDD\|235110	PRK03188, PRK03188, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional.	7.74936e-156
NC_008578.1\|WP_169303217.1\|190921_192937_+\|glycoside-hydrolase	gnl\|CDD\|366032	pfam00331, Glyco_hydro_10, Glycosyl hydrolase family 10.	3.87896e-159
NC_008578.1\|WP_011719027.1\|200868_202026_+\|EfeM/EfeO-family-lipoprotein	gnl\|CDD\|271139	cd14656, Imelysin-like_EfeO, EfeO is a component of the EfeUOB operon. This family includes the EfeO domain, an essential component of the EfeUOB operon which is highly conserved in bacteria. However, its biochemical function is unknown. EfeO contains an N-terminal cupredoxin (CUP)-like domain and C-terminal imelysin-like domain that may bind iron. Algp7, a member of EfeO family protein from Sphingomonas sp. A1, is found to bind alginate at neutral pH, but does not contain the CUP domain, thus having a role that does not seem to be related to iron uptake. Some members of this family are fused to an N-terminal putative EfeU ion permease domain. The imelysin-like domain of this family also contains the GxHxxE sequence motif and a highly conserved functional site, suggesting a similar role to other imelysin family proteins containing the same motif.	3.13045e-94
NC_008578.1\|WP_011719035.1\|208419_209907_+\|PhoH-family-protein	gnl\|CDD\|224787	COG1875, COG1875, NYN ribonuclease and ATPase of PhoH family domains [General function prediction only].	8.71431e-118
NC_008578.1\|WP_011719029.1\|203506_204274_+\|metal-dependent-transcriptional-regulator	gnl\|CDD\|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	1.0885e-45
NC_008578.1\|WP_011719023.1\|196901_197843_+\|zinc-binding-alcohol-dehydrogenase-family-protein	gnl\|CDD\|223677	COG0604, Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only].	1.52389e-57
NC_008578.1\|WP_011719021.1\|194120_195044_-\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	1.97077e-105
NC_008578.1\|WP_011719031.1\|205441_206167_+\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	9.07926e-07
NC_008578.1\|WP_041834857.1\|210092_211385_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	1.86742e-27
NC_008578.1\|WP_011719030.1\|204379_205369_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.26651e-81
NC_008578.1\|WP_011719022.1\|195237_196191_-\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	1.4985e-35
NC_008578.1\|WP_011719017.1\|187182_188055_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	3.67548e-116
NC_008578.1\|WP_041835184.1\|207471_208062_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.15252e-58
NC_008578.1\|WP_011719026.1\|199955_200807_+\|FTR1-family-protein	gnl\|CDD\|251822	pfam03239, FTR1, Iron permease FTR1 family.	4.61323e-49
NC_008578.1\|WP_011719032.1\|206251_207448_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.61422e-37

>NC_008578.1|WP_083760609.1|198770_199442_-|M15-family-metallopeptidase
MAASTPAPIATTASPTPPAGRRPTVTPTPTQSAGTGGFVSSVRPVSAQELGASWHPGCPVSPDQLRQITLSYWGFDGQPHLGRLVVNVSAVTAVTEVFQRLYQARFPIRSVRPIAEFGGSDDASMAADNTSAFNCRYAVAAGPPRWSVHAYGLAVDVNPVENPYLDGGRVLPAGGARYVDRSRYQPGMAVAGGVLVQAFAAIGWRWGGRWASPDYQHFSATGG
>NC_008578.1|WP_011719023.1|196901_197843_+|zinc-binding-alcohol-dehydrogenase-family-protein
MKTRAARLIRHGEPLVVETVELPEPGGDEVCVELAFAGVNPVDSYIIAGRVAPDAPLPRIVGIEASGYLDGRPVLVYGEGFGRDRDGGYARHAVVPRSAVHPLPEGIDLAVAACIGVAGATAWRVVEMAGVGNEDRVLVLGGAGGVGLPVISYARSKGARVWAQTSNPEKVDAMHRAGAEKGVVADAAALAAAIADFAPTVVFDPLGGSFTGIAIRALQPRGRLVIYGTSAGPDAEIPLQVLYRNNLRMLGYGGLIASPEELREAVTAAIAAVAAGRMHIPVGARVALDQINEAFALLRRRSIPGKIVVDLRD
>NC_008578.1|WP_011719022.1|195237_196191_-|NAD(P)-dependent-oxidoreductase
MRVLIAGGSGAVGRPLVALLASAGHEVVATTRMAEKMPLLRRLGATPVVMDGLDPKAVGDVVARIEPEVIIHQMTGLAGAQNLRRFDRAFSVTNQLRTRGTEYLLAAARAVGVRRFVAQGYGGWPYAPGAGELSTEETPFDSEPLFGRARRTLDALRRQEELVASSPLSGVVLRYGTFYGPGASDELVALVRRRRLPIIGKGSGVWSWIHVEDAAHAAVAAMHANAEGVFNIADDEPARVTEWLPYLARVLGAPPPRRIPAACGRLIAGAAVTALMTQVAGMSNAKAKTELGWRPRWSTWRLGFRDGLSSAVHEHAT
>NC_008578.1|WP_011719021.1|194120_195044_-|RNA-polymerase-sigma-70-factor
MADGAYPTLQRMLFSVAYRMLGSVAEAEDIVQEAFVRFYALDADRVRDIESVPAYLTAVVTRLSIDYLRSARARREQYVGTWLPEPLVTEHSVVDGARYVEQLDSLSIAFLVVLERLSPLERAVFLLHDIFDYSYPEISRMIGKSATYCRQLAVRARRHVQASGRRRTKISQNEQERLARRFFAAVGDGDVAALVDLLVMDAAAYGDGGGQAPAARIPICGRDRVAAFLASLGRTARRLGVRYRVTEINRQPGALFFNRSGQLLSVAILDIGENGVGAVYSIVNPDKLQHLGPVGDVRELLRKGVPS
>NC_008578.1|WP_041834854.1|193132_194065_+|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase
MSVTVQASAKINLYLRVGPLRSDGYHDLATVFHAVSLHDEITVEESEHLSLEICGEQAEKVPLDGDNLAVRAAMLLARRLGREPGVRIVLRKGIPVAGGMAGGSADAAATLIACAALWHAELPHDELMTLAAQLGSDVPFCVVGGTALGHGRGERLAPVLAAGPWYWVLALADGGLSTPQVYAEFDRRRASGDGELREPGDGEPLDVPAALLSALRDGDPKRLGSLLHNDLQDAAVALRPALGRVLEAGLDGGALGGIVCGSGPTCAFLVSDQDAAVDLAARLAGSGWVRAVRCATGPAAGARILARTAG
>NC_008578.1|WP_169303217.1|190921_192937_+|glycoside-hydrolase
MVTSASVVGVATLAAATVLITGGIAHAASTLKQGAEANGRYFGVSASVNTLNNSAAANLVATQFDMLTPENEMKWDTVESSRGSFNFGPGDQIVAFATAHNMRVRGHNLVWHSQLPGWVSSLPLSQVQSAMESHITAEVTHYKGKIYAWDVVNEPFDDSGNLRTDVFYQAMGAGYIADALRTAHAADPNAKLYLNDYNIEGINAKSDAMYNLIKQLKSQGVPIDGVGFESHFIVGQVPSTLQQNMQRFADLGVDVAITELDDRMPTPPSQQNLNQQATDDANVVKACLAVARCVGITQWDVSDADSWVPGTFSGQGAATMFDSNLQPKPAFTAVLNALSASASVSPSPSPSPSPSPSPSPSPSPSPSPSPSPSPSPSSSPVSGGVKVQYKNNDSAPGDNQIKPGLQVVNTGSSSVDLSTVTVRYWFTRDGGSSTLVYNCDWAVMGCGNIRASFGSVNPATPTADTYLQLSFTGGTLPAGGSTGEIQSRVNKSDWSNFTETNDYSYGTNTTFQDWSKVTVYVNGRLVWGTEPSGTSPSPTPSPSPTPSPSPSPSPSPSPSPSPSPSPSPSSSPSSGCVASMRVDSSWPGGFTATVTVSNTGGVSTSGWQVGWSWPSGDSLVNAWNAVVSVTGTSVRAVNASYNGVIPAGGSTTFGFQANGTPGTPTFTCTTS
>NC_008578.1|WP_011719018.1|188339_190310_+|PHB-depolymerase-family-esterase
MRRIGRRLAVWLSAGTVAITAAMTGFLGAGGARAASTGPIPPGVLTQVTNFGTNPTALNMYVYVPQNLAARPALLVAIHYCTGSAQALFSGYAHDFVTAADRYGYIIVFPEATRSGQCFDVYSPQALARNGGSDPQGVMSMVSWVESQYPIDRSRVFAMGVSSGAMMTNVLLAEYPDVFAAGVAFMGVPYGCFATGSASVTWNSQCANGQVIKTAQQWGDLARSAYPGYTGGYPRIQLWHGTADTTLNYANLGEEVKQWTNLHGLSTTPTSSDSPVSGWTRSRYGSTTTQPPVEAISVAGAGHVLPQTGMDAYAITFLGLDSAGGSVSPSPSPSPSPSPSPSPSPSPSPSPSPSPSPSPSPSSSPVSGGVKVQYKNNDSAPGDNQIKPGLQVVNTGSSSVDLSTVTVRYWFTRDGGSSTLVYNCDWAVMGCGNIRASFGSVNPATPTADTYLQLSFTGGTLPAGGSTGEIQSRVNKSDWSNFTETNDYSYGTNTTFQDWSKVTVYVNGRLVWGTEPSGTSPSPTPSPSPTPSPSPSPSPSPSPSPSPSPSPSPSSSPSSGCVASMRVDSSWPGGFTATVTVSNTGGVSTSGWQVGWSWPSGDSLVNAWNAVVSVTGTSVRAVNASYNGVIPAGGSTTFGFQANGTPGTPTFTCTTS
>NC_008578.1|WP_011719017.1|187182_188055_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MSDAGHVDAVCKPLGAADIRELARSAGVRPRKTFGQHFVVDPGVLRKIARYAELSSEDIALEIGPGFGSLTLVLLPLVRRLLAVEIDRVLAAVLPETIRRRCPAFADRLVVVHGDVLRLTTLPDDPTVLVANLPYNVAVPAVLRVFERFSTVTRTVIMVQREVAERLCADPGSPAYGAPSIKLRWYGRARIVGSVSADVFWPRPQVESAVVRIDRQPPPVPGVDRAAVFAVIDAAFAQRRKMLRRALSGWAGSAQAAEERILAAGLRPTDRGEALTLADFIRLAQAPPTR
>NC_008578.1|WP_049751316.1|185955_187062_+|DUF348-domain-containing-protein
MRKRLILATGSGLVAAAVLSAAAGYAAHQASVVLVVDGHVQHVRTHARSVADVLKKQHIAVGPHDSVTPATNSRIHDGQTVTVTHGRLLTVTVDGVTRRVWVAANSVADALRYIGIRTAGARLSVNRFARVPLSGMDISINLPHTLSVVVDGRVQSIVTTDDTIGGALQSAGIRLNPDDEVSVPLEERPADGVTVVITRITIGQTTEQVPIPYNTVTTYDSSLYVGTRKVSQLGHNGVLVRTYRVTYANGTERSKQLLSSQVSVPPTPQVVLVGTKPIPVAPAPTYSVKSDGLNWAALARCESGGRPNLVDPPYYGLYQFTLPTWRAVGGRGLPSDASPSEQTYRAQLLYQRSDWRRQWPVCGHYLFS
>NC_008578.1|WP_011719015.1|184776_185601_+|TatD-family-hydrolase
MSDYRPAATERPAPPIPPRLAAPAVDAHCHVDLLDVPVAEAVAAARAAGVERLVTVGYSVPSSQWCARVAEEHAEVVAAVAVHPNDAMDADADALGVIAELAALPQVRAVGETGLDYYWKRTDPAVQQEIFRRHIDIAKQLGKALVIHDRDAHADVLRILDEVGPPERTVFHCFSGDLAMAKMCVEKGYFLSFSGTVTFKNAPDVREAAAWTPLDAMLVETDAPFLTPMPYRGHRNGPYLVALTIRAIAALKGVPEEEVATRTAANALQVFGSW
>NC_008578.1|WP_011719026.1|199955_200807_+|FTR1-family-protein
MLATYVIGLREGLEAALIVGIIAAFLRRQGRMDALRLVWVGVSVAVALCAGVAVTLQVISAELPTRAQEGLETVVAVLAVCMVTTMILWMRRHARALKGELERAAAWALEHGSAYAMVGMAFLAVLREGSETAVFLLAVLQQPGVRAITAGGGVIAGLVTAVVIGWGIYRGGVRLNLTRFFRATGVVLVLVAAGLVMSALHTAHEAGWLNAGQSQPIDIAWLVRPGTPIAALATGVLGLQPHPALAEIVGWCCYVLPMLAVVLRQPRRPATTPRVAPEVSATS
>NC_008578.1|WP_011719027.1|200868_202026_+|EfeM/EfeO-family-lipoprotein
MASVRRFGPAGGVRRFGLVGGVVLALVSGCSSDSGGTTPRGIGTDAGTRNVNIVVTAEGCPPSPARVDAGLIRFHVRNQNASAVTEAELLAGSTILGEKENLVPGLDGTFTLRLQHGRYTVYCPNAKQPRSDFVVTGENASPTAAAATEAAARYHQFVVGQVQALVTGTATFCAAVKAGDLAAARRAYPAARWHYEAIEPVAESFGDLDPAIDARLDDVADPAEWTGFHRLEKALWQDDSLAGMTAVADRLQSDVRTLADLVATQTYQPAQIANGAVELLDEIARSKVTGEEERYSHTDLYDIDANLAGSKAAFQAVEPILRERDPALATTIDARFADVEAALRPLARGTGWVSYEAVDAATRRNLAQRIDALAEPLSRVAAVVG
>NC_008578.1|WP_011719028.1|202043_203336_+|deferrochelatase/peroxidase-EfeB
MTEASGGVTRRRFLGGLGLAGGGLGIAAAFTGGSAAGAVLGLVDRSPDGRSEQAAGAVSTPGRVVPFRGRHQAGIITPAQDRLVFGAFDVVTDSAGALRDVLDAWTIAAEAMTQGRSVPADDGSPQAPPTDTGEALGLPPAALTVTIGYGPRLFARFGLATRRPSALAELPPLPGDRLDPARCGGDICIQACSDDPQVAFHAVRNVTRLGRGVVVLRWLQLGFGRTSSTTTGQQTPRNLMGFKDGTRNLRADDTAALDRHVWIGTETDQPWLIGGSYLVARRIRMLIEAWDRASLSEQERVIGRRKVSGAPLTGSREYDPPDFSAVRAGELVIPSDAHIRLASPEHNAGRRMLRRGYSYTDGIDLSTGELDAGLFFISFHKDPATFIAVQRILGTQDALREYIVHTGSALFVCPPGLQDGESWGRQLFGA
>NC_008578.1|WP_011719029.1|203506_204274_+|metal-dependent-transcriptional-regulator
MRENRTVNQAHDLIDTIEMYLRTIYELEEEGVVPLRARIAERLGQSVPTVSQTVARMERHGLVHLEGDRRLELTPQGRAAATRVMRRHRLAECLLVDVIGLDWELVHEEACRWEHVMSEEVERRLLEILGHPTESPYGNPIPGLDELGEPRRDVAFREGLVPLPSIPDQFDRVIVRRIGEPLQSDRALLGRLRRAGVRPNVPVPVRRESRGGVWLGREPDAVHLEDAAAAHVFVRPVELEGVDGSAAAAGAAARA
>NC_008578.1|WP_011719030.1|204379_205369_+|ABC-transporter-ATP-binding-protein
MTDRVTAATGVADSARPDVERRVPTDGPAKETVGVRLDGVRKSFGAVRAVDGIDLTVCPGETVALLGPNGAGKSTTIDMILGLLAPDSGSIAVFGTTPHAAVRRGAIGAMLQTGSLLRDLTVRELLAMMASLYPRHMAVDDVLELMGIRAIAQQRTERLSGGQVQRVRAALALLPDPELLVLDEPTVALDVESRRAFWQSIRDFAAQGRTVVFATHYLDEADSYADRVVVLSRGRIVADGPANEIRAMAGMRTIRATIPEADDARLAALPGVRMVERRGSAVVLRCADSDAAIRAVLAVYPDAKDIEISSAGLEEAFLYLTGDGRHAGP
>NC_008578.1|WP_011719031.1|205441_206167_+|ABC-transporter-permease
MNATYLRYELLRLFRNRRYFLFSLAFPLLFFYLIAGNNRHVTLDGIPFPTYYLAGMTAFGTVGAMVAAGGRIAAERAVGWNRQLRLTPLRTVDYVWAKVLTAYAMAVVTIVVLFFAGATLGVPLRFSEVLAMTGLVLVALVPFAALGILLGHLLTPETMGPVAGFGVAVLAFLGGAWGPIGATGVLHHVSQAIPTYWLVRAGRLLLGEPAWSPLGWFVVVTWSVVLGVLAGWAYGRDTKRV
>NC_008578.1|WP_011719032.1|206251_207448_+|two-component-sensor-histidine-kinase
MTVPESSGVGGSRLRARCTPSAGTRWRRAGGIWLFYLLGPLIAAWRSSSPVVAVVGSFLLLAFSVVYLFGFPRVWPAARRRRDVVLVSGTLVILSAASIALIGPSALATWVFVAVTWVVLLRWQIAVPLVLALAAAALAVPQHVPGWHLRGPQWSLAASIAFASFAVLAVVRANQSLAAARAEVAQLAAERERLRIARDLHDLLGHSLTTITVKAALAARLADRDLTRARNEIADVEALARRTLADVRAAVAGYRDVRLATEIATAREVLAAAGIEADLPRVVDDVPAELAGLFGWVVREGVTNVVRHSQAKRVRITVDQRVIEVVDDGVGVLSAVADAALAASGSGGGGGHGLLGLAERVAAAGGRLITGPADGFGAPGFRLRVEVPALALTSGEAS
>NC_008578.1|WP_041835184.1|207471_208062_+|response-regulator-transcription-factor
MADDQHLVRGALATLLALESDIEVVAEVGRGDDVVEAARRTAADVAVLDIEMPGLDGLAAAAALRREVPDCRVLIVTTFGRAGYLRRAMEAGVSGFLVKDAPVERLVDAVRRVAAGQRVVDPELAAATLAAGANPLTAREQEVLAAARGGATIADIAGRLFLSEGTVRNYLSAAIAKTGARNRIEALRVAEENGWL
>NC_008578.1|WP_011719035.1|208419_209907_+|PhoH-family-protein
MATTYEPPASPSRPAGGNPDTVTPAPGTEHPVPGAGPLTRSAAQTGHVVVLDTSALMADPEGIFDAYPGADLVIPLAVIQELDGLKKRLDPAGAAARDVLRRVEALRLAAGGDLREPLQRRVGGTVRMQVNGVHAALLRRYGLHADSPDNRIVGTALALAAAQPDGPQVLVVSNDTALRLTAAAVGLAAAEHNPLDAAPAHARPDGWIALEVSPEVLDQLFENRLIDAASVGASDVAENTFVVLRAGTSSALARYRNGLLRVLDQLPPIWGLRPANKEQRFALDLLLDDDVRVIVLDGPAGTGKTLCAVAAGLHMVVEQHRFERMSVYRPVIPVGQADLGYLPGTLDEKIDPWMAAITDAVAALSGDGLDRRRRQEGTRGKVAQDSLDYIKAQGLLTMESVTHLRGRTLHSTFVLVDEAMNLSPQVGKTLLTRIGADSKIVLTGDTSQIDAPFLSERTNALTAVVSAFAGQPCFGHVRLTRGERSPVAELAARLM
>NC_008578.1|WP_041834857.1|210092_211385_+|C40-family-peptidase
MRAGRWLTTVGLVVAFTVGATCPALADKPPIIPSQSEVDAARAAAQAKAAAVAQTEQALADANAQLQKLNDQVETLVEAYNGAMVRLQDAQAKARAAAANLAAARAAHEQAQIEMDQFAALTYMGAGDVAKLTALLFAPDPERFLTRAGTLAAIDRHRQGIIALTEATAQAEASAAAAAAQALGQQQKAADAAARAKDAAVQAVNAQAAEVAQITQRKQDLQAQLAVLQGKAKSLAEARARGLAELAAQRAAAAAAAAAAAKRRAAEQAASESGTGSSAGPVGNLPTPGMGHSISTPQQRAGAVAFARSQIGVWYRWAGAGEVGPTVTDQGIQNVPGYDCSGLVMRAYESVGIELGHYTGLQWDEGMHVSQDQLMPGDLVFFATNVNDPSTIHHVGIYIGNGQMIDAPQTGEQVGIHNAFRPDYIGAVRP

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Crispr_ID: NC_008578_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_3

561069-561157

Orphan

Consensus_repeat	Method
ATTGGTCCCGGTGAGTGCGGATAGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_3

>merge|NC_008578|3|561069-561157|CRISPRCasFinder
ATTGGTCCCGGTGAGTGCGGATAGCGGGCTCGTCTCGGCGGTCGTTTGTGAGCCCGTCGGACATTGGTCCCGGTGAGTGCGGATAGCGG

>NC_008578|3|3|561069-561157|CRISPRCasFinder
ATTGGTCCCGGTGAGTGCGGATAGCGG	GCTCGTCTCGGCGGTCGTTTGTGAGCCCGTCGGAC
ATTGGTCCCGGTGAGTGCGGATAGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_011719365.1\|563975_565112_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NC_008578.1\|WP_011719371.1\|569046_570318_-\|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|235037
NC_008578.1\|WP_011719368.1\|566675_567056_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341405
NC_008578.1\|WP_041834899.1\|561421_562042_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011719353.1\|550177_550774_-\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011719357.1\|555554_557948_+\|phosphoketolase-family-protein	unknown	unknown	gnl\|CDD\|235379
NC_008578.1\|WP_041834898.1\|560286_560526_-\|sulfurtransferase-TusA-family-protein	unknown	unknown	gnl\|CDD\|376492
NC_008578.1\|WP_011719361.1\|560566_560980_-\|DsrE/DsrF/DrsH-like-family-protein	unknown	unknown	gnl\|CDD\|225120
NC_008578.1\|WP_011719356.1\|552659_555395_-\|bifunctional-GNAT-family-N-acetyltransferase/acetate--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|131764
NC_008578.1\|WP_083760614.1\|548936_550100_+\|GAF-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_008578.1\|WP_011719370.1\|568033_569044_-\|ribosome-small-subunit-dependent-GTPase-A	unknown	unknown	gnl\|CDD\|224084
NC_008578.1\|WP_148204510.1\|565813_566494_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NC_008578.1\|WP_169303179.1\|563515_563683_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011719359.1\|559122_560274_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NC_008578.1\|WP_011719366.1\|565142_565703_-\|YceI-family-protein	unknown	unknown	gnl\|CDD\|377274
NC_008578.1\|WP_148204509.1\|557935_558976_+\|acetate/propionate-family-kinase	unknown	unknown	gnl\|CDD\|234680
NC_008578.1\|WP_011719369.1\|567163_567961_-\|histidinol-phosphatase	unknown	unknown	gnl\|CDD\|238819
NC_008578.1\|WP_011719363.1\|562207_562993_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224500
NC_008578.1\|WP_011719354.1\|551039_551717_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_008578.1\|WP_011719355.1\|552026_552593_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_011719371.1\|569046_570318_-\|3-phosphoshikimate-1-carboxyvinyltransferase	gnl\|CDD\|235037	PRK02427, PRK02427, 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional.	1.6593e-155
NC_008578.1\|WP_011719368.1\|566675_567056_-\|CBS-domain-containing-protein	gnl\|CDD\|341405	cd09836, CBS_pair_arch, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	2.19346e-27
NC_008578.1\|WP_011719355.1\|552026_552593_+\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	2.09708e-24
NC_008578.1\|WP_148204510.1\|565813_566494_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	6.98441e-15
NC_008578.1\|WP_011719357.1\|555554_557948_+\|phosphoketolase-family-protein	gnl\|CDD\|235379	PRK05261, PRK05261, phosphoketolase.	0
NC_008578.1\|WP_041834898.1\|560286_560526_-\|sulfurtransferase-TusA-family-protein	gnl\|CDD\|376492	pfam01206, TusA, Sulfurtransferase TusA. This family includes the TusA sulfurtransferases.	2.32954e-22
NC_008578.1\|WP_011719361.1\|560566_560980_-\|DsrE/DsrF/DrsH-like-family-protein	gnl\|CDD\|225120	COG2210, COG2210, Peroxiredoxin family protein [General function prediction only].	1.51462e-41
NC_008578.1\|WP_011719356.1\|552659_555395_-\|bifunctional-GNAT-family-N-acetyltransferase/acetate--CoA-ligase-family-protein	gnl\|CDD\|131764	TIGR02717, Uncharacterized_protein_MJ0590, acetyl coenzyme A synthetase (ADP forming), alpha domain. Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.	8.39194e-153
NC_008578.1\|WP_083760614.1\|548936_550100_+\|GAF-domain-containing-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	5.51966e-43
NC_008578.1\|WP_011719370.1\|568033_569044_-\|ribosome-small-subunit-dependent-GTPase-A	gnl\|CDD\|224084	COG1162, COG1162, Predicted GTPases [General function prediction only].	7.30506e-85
NC_008578.1\|WP_011719354.1\|551039_551717_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.07311e-72
NC_008578.1\|WP_011719366.1\|565142_565703_-\|YceI-family-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	1.0491e-59
NC_008578.1\|WP_148204509.1\|557935_558976_+\|acetate/propionate-family-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	3.45267e-138
NC_008578.1\|WP_011719369.1\|567163_567961_-\|histidinol-phosphatase	gnl\|CDD\|238819	cd01641, Bacterial_IMPase_like_1, Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates.	1.96029e-81
NC_008578.1\|WP_011719359.1\|559122_560274_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	2.80357e-36
NC_008578.1\|WP_011719365.1\|563975_565112_+\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.20541e-53
NC_008578.1\|WP_011719363.1\|562207_562993_-\|hypothetical-protein	gnl\|CDD\|224500	COG1584, COG1584, Predicted membrane protein [Function unknown].	2.22424e-18

>NC_008578.1|WP_011719361.1|560566_560980_-|DsrE/DsrF/DrsH-like-family-protein
MTKKMSLVVFSGTADRLQAAATIAAGEAAMGVETHIFLTFWGLTALRTSELGNPRPLPAEYGAQTEALRTLMQEKNVPPWHEVLRQASDIGDVHVHACAMTADLMGIGKEDLDPMVEDVIGVGRFIELADDGQILFI
>NC_008578.1|WP_041834898.1|560286_560526_-|sulfurtransferase-TusA-family-protein
MMSVTADKEIDARGSFCPGPLMEMIHAIRDAQVGDVVAVLSKDPGSRTDIPAWVTKAKHELLAIEDHGDYARFVVRKAR
>NC_008578.1|WP_011719359.1|559122_560274_-|FAD-dependent-oxidoreductase
MDTRHRPRIVVLGGGVGGTLTANLLARRLGTRAQVTLVDRTGLHIYQPSFLYAAFRPLPTRSLGRDLRSLLRRDIRLVVDEVTTIDPASRTAGLRHGQNLEYDFLVIALGSQLAPERIPGLAEGSHNFYSLAGAQRLHTALHEFSGGTVLVGVAGIPYKCPPAPIEFTFLLDDYLRRRGLRSATTIRFLSPLNRAFTIASASRMIEPIFEERRIELHTFVNVAAVDPEKHIVTTLEDETYDYDLAVIVPPHTTPAVLRNAGLTDGDWVPVDRQTLAVRGQENVYAIGDCTDLPISKAGSTAHFEARVVAERITAAVEQRPVDPTRGTYHGKVMCFLETGGGKATYLVFDYDHEPRPPQPSRIWHLGKAVLNQAYWVTVPQGRL
>NC_008578.1|WP_148204509.1|557935_558976_+|acetate/propionate-family-kinase
MAVVGDVRRVLVVNTGSSSTKVSLVVDGAVTDRWSSLDVPLPDVDAVAHRFVHGGERLGPVALIDNQVRTALEAAAELAPLHQGRALEVLDMLQSRLPQVPHVACFDSAFHATLPPEAATYALPAEWNERYHIRRYGFHGFSHAWAARRAREWCPGARRVVTCHLGSGASLAAVCDGISVDTTMGFTPLEGLVMATRSGDVDPGLVLWLAEREPDVAAALASRSGLLGLAGTADMREILARDDEQARLARTVYLHRLRKGIAAMAAAMGGIDVCIFTGGVGENAPQIRAGAADGLEFLGISIDPERNQRAVPDEEISASGARVRTLVVAAQEDRQIAEDVRLFFQR
>NC_008578.1|WP_011719357.1|555554_557948_+|phosphoketolase-family-protein
MTEPTAGPGDAVLSDQELAAIDAYWRAANYLCVGQLYLLDNPLLREPLRPEHIKPRLLGHWGTTPGLNFIYTHMNRFIRRDDWNAIFITGPGHGGPAPVAQAYLEGTYSEIYPSITRDEEGLRRLFRQFSFPGGIPSHAAPETPGSIHEGGELGYSLAHAFGAVFDNPDLLAVCVVGDGEAETGPLATSWHSNKFLNPRHDGAVLPILHLNGYKIAGPTVLGRIPRSELLALFEGYGYRPLLVAGDDPAAMHQLMARTLEEALDDIREIQRRARSGVPGRPTWPMIILETPKGWTGPCEVDGRPVEGSFRSHQIPLTDPRGNAEHLAMLEAWMRSYRPEELFDAHGAVRPELTDLAPRGARRMSANPHANGGVLLRDLFLPDFTAYAVPVEKPATTTSEATRVLGRYLRDVLALNAESRNFRIFGPDETASNRLDAVFDVENRMLNADILPTDDHIAPDGRVMEVLSEHLCQGWLEGYLLTGRHGLFNSYEAFIHIVDSMFNQHAKWLKVTRSLPWRRPIASLNYLLSSHVWRQDHNGFSHQDPGFIDLVVNKKAEVIRVYLPPDTNTLLSVMDHCLRTRNYVNVVIAGKQPALNYLSMPDAIAHCTRGIGVWSWASNDMGDDGRGEPDVVMAAAGDVPTLEALAATALLREFFPDLRVRFINVVDLMRLQPSSEHPHGLTDAEFDALFTTDKPVIFAFHGYPWLIHRLTYRRTNHKNIHVRGYKEEGTTTTPFDMAMLNDIDRYHLVMDVIDRVPSLGTRAYHIRQRMADERLAKRRYTRDVGDDHPDVKNWVWPW
>NC_008578.1|WP_011719356.1|552659_555395_-|bifunctional-GNAT-family-N-acetyltransferase/acetate--CoA-ligase-family-protein
MTASTEEQRIHGGVRSEEVHIDALLTDAGIVHIRSVRPTDASALRDMYASVSDDTIYMRFFTMSRASVEEDIAALCRPPDDRHFVLVAELGGRIIGLATYETLDWDRTRAEVAFLVEDTQRGRGVGTLLFEHLAALALQNGVKTFIAEVLPENNPMLRMLRDIGLPRKARSLEGVVHFEIPLTMDETYRAAVDRREAAANARSLARVLSPKVVAVVGAGANPQGLGHQILVNIVQGGYRGEVFAINRSGHRVAGVPAYASLADLPASPDVVIVAVPAAEVLAVARQAAQRHPAGLVVISAGFAEAGAEGAERQRELLAICRAAGMRLIGPNCMGIANIDPEISLNATFCATMPPPGGISLMSQSGAVGIAALNHAARSGVGLATFISAGNKADVSGNDVLCAWESDPRTRVCALYLESFGNPRKFARIARRVGKAKPIVAVKAGRTLAGIRGAASHTAAAATPDVVVDSLFAQAGVTRVDSLEDLFNVATFFDVAPLPAGRRVAIVGNSGGPGVLAADACEAAGLEVIQLGERTRTLLRSLLPEGAAVDNPVDVVASTETRVFEAALRIVAHDPEVDAVVVVFTEIRPGSIPETAKAIAKVSREYSGKPFVACLLGHPGIPDELTDGSGRLLVPVYAFPEPAVRALAAAERYARWRRRRPGTFPHFEDLDRESAAALVAATLAEHPEGTWLDTPAAVQLLTAYGITLAPTVAAKSSAEAVAAAERIGYPVVLKPAAGSFVHKTELHAVKLNLTSAEDVAAAFADIASRLDLGDTGVVVQPMLRGGVEAALGVVTDRTFGPVVMVGLGGVASDLLADRAFRLPPLTVEEADEQIRSLRTAPLLFGYRNAPPTKVEALRDMLLRLAELASALPEIAELDLNPVLVSPDGAVALDAKVRLAPAPHDDPLVRRLR
>NC_008578.1|WP_011719355.1|552026_552593_+|universal-stress-protein
MIEVIQRSEPVALPSVVPWRLQRIVVGVDGSENSLAALSAAVQLAARDGATVEAVCAYHTYHSAYFDALLTKHYGSRPPDYVGPGAPSGAAGDALDTLEEAARKIIGPKLPDTLLLRAIQGHPADVLVKASENADLLVVGAHGRSGVLGSLLGSTTQTCIRYAGCPVLVVPPQVKSRFSAEQTAVVMR
>NC_008578.1|WP_011719354.1|551039_551717_+|response-regulator-transcription-factor
MTEERPPIRVFLVDDHEVVRRGLTQLLEAESDIRVAGEAGTAAEALARVPAVRPDVAVLDVRLPDGDGVEVCRELRSALPGLACLILTSFADDDALYRAILAGASGYVLKQIRGNEIVSAVRTVAAGGSLLDPVTTTRVLQRLRDQAERPEPGNPYAALTEQERRVLELIGEGLTNRQIGERLFLAEKTVKNYVSSILAKLGLQRRTQAAVLAVEHRPRGSQPQT
>NC_008578.1|WP_011719353.1|550177_550774_-|hypothetical-protein
MKRKVFDILVSAGGLLVALVLIVAGALAMWGASFANSSVHNQLAQQQIFFPQKGDPQLANPKIGPYLTKYAGQQVLTGAQAKAYADHFIAVHLSEMPYGGVYAKISELALKNPNDAKLQALKQTSFQGTTLRGLLLTAYAFSVFGEIAFWGGIAAFILAGVMLILVGLGFWHARRTPPQAEILTSEPRGQPQAQPQHA
>NC_008578.1|WP_083760614.1|548936_550100_+|GAF-domain-containing-sensor-histidine-kinase
MRDPEQLHALLDAVLLIEQDLDLRSTLQRIVGAACALTGARYGALGVLDAAGTGLSEFVYTGLDAETAARIGPPPKGIGVLGLLIRDPRPIRLADLAAHPAAVGFPPGHPPMRSFLGVPVRVGDDVYGNLYLTEKRDAAEFTADDEALVVAFAKAAGLAIRNARLHARVEELALAADRERIARELHDTVIQRLFATGLALQSVVPITEVPAVRKQILETVADLDETIRQIRTTIFSLEPPPETAPSLRARLLEITSDAARGLGFEPEVRFAGPVDAVVPEPIGREILVVAREALANVARHAHARHVEVRLAVDGGESAAGGAPAAVILSVTDDGVGVDEAVIHGGRSRRGGHGLRNMRERAEALGGVFSIQPVDGGGTLLEWRVPLT
>NC_008578.1|WP_041834899.1|561421_562042_+|hypothetical-protein
MDVRRSATWWRRIAVGLAVGCASILGLVGLPSIAVAAPSASPGSVIDCLDWQQRAASGTACADITPTFACVWNNGDGTYTAALGYVNPSSYTLELQPGSYVNSFYGKKGDPNNWGQPALYPPGTSTTYFTITWSQQWQYTLLWQLGTAGHTVTFSSASTPCTSKPVSIIGNVGLVGAALLGALVVFVFLNRRVERRRRETTKASAC
>NC_008578.1|WP_011719363.1|562207_562993_-|hypothetical-protein
MEASNARTAEPYPRAENPMTSSAQLVYPDDQTGWLARTRVTLSPMAAPSILGFFGLFVAAVMVGAWQAGWYGTDATPAVLWPLVMLFGGLAQLVAGFAALRARDAVAVALHGTWGAFWLAWGVLQILVATGVNSAIAIGSADTGLAFWFLAVGAVTLLTALAAIPYHLGFAAVAWTLTAAAGLSAAGFWAGDLNTTRAGGVLFVIAAAIAWLVAGAMVFEGATGRTVLPSGRLAKGASIPGRSAIQPLEFSAGEPGVRIGQ
>NC_008578.1|WP_169303179.1|563515_563683_+|hypothetical-protein
MEHTQQDVGAMISLTPEQYRRAALVVCGHARDRDDAAELLDALGLRAALSSHAAA
>NC_008578.1|WP_011719365.1|563975_565112_+|EAL-domain-containing-protein
MPTEATRGAVPAEGSIEACARLLPGLLRDPEQPRLVFQPIVDLDRAVVAGYEALARFAVSPPVAPDVWFAAAAAGGLAAELERRVVRRVLAARSHLPPNCFLTVNVSPQALTTDDVLDEFRHGGDLAGIFVELTEQQHVLDLAATHKALEELRQHGAMIAMDDAGSGYSGLQRLVALRPELMKIDRSLVSGIDSDEAKKACVEMLRVLAGRLDAWLLAEGVETPEELRTLVSLEVPLAQGFLLGHPVDDWRGLDARTTARIRVAARELLGSRQLVRLVERVAIRTPEAAEPPGSSDVVVCLDGDGRPASLLINSDAGRPRTVPVTLQLPATTPITEAARQCLDRPQPYRFDPVLCVHEDGTVAGIVHAERIFDFLTRR
>NC_008578.1|WP_011719366.1|565142_565703_-|YceI-family-protein
MTTTTVETLPGYIAGTWTIDPVHSEVGFTVRHMMVSKVRGRFTKFDGQIITAENPLDSQVTATIDVASISTGDENRDNHLRSSDFLDVAHHPTMTYRSTGVRRDGDRFIVDGELTLRGVTRAVPLVVEVNGFGPDGYGGTRAGFSATAEINRRDFGVNWNAALDNGGVVVGDKVTINLEIEAILQK
>NC_008578.1|WP_148204510.1|565813_566494_+|MarR-family-transcriptional-regulator
MSPQSAASRLGAAVSPRPAERGRTVSARPGDGGHSRPAVAQGGHRTPAGASPGAAGSEPRWLTDDEQRVWRLFLAVNRLLWARLEQELQRDAGMPHAYYEVLVHLSEAPGRRLRMSQLAERSLSSPSRLSHAVNRLERLGWVVREALPADRRCQIAVLTDAGFAALAAAAPGHVEGVRTHLFDALTPEQVRQLGDICQAIVQRINAVPCRQCAPPTRPRTGTVPDS
>NC_008578.1|WP_011719368.1|566675_567056_-|CBS-domain-containing-protein
MRVADAMNPLVLTVGPNHTLREVARRMAERKVGAAVVIDPENGIGIITERDLLESIAAGENPDAEPVSAHLTRELVYAAPDWDLDQAATAMIRGGFRHLVVLSGNEVVGVLAMRDIVRSWVSTGVR
>NC_008578.1|WP_011719369.1|567163_567961_-|histidinol-phosphatase
MSDPTAADLALALRLADLADEISLSRFQAMDFRVETKPDLTPVSDVDLSVEREVRRVLAADRPGDAVLGEEFGGEPVDGRVWVIDPIDATKNFVRGVPIWATLIALLDAGEPVIGVVSAPALASRWWAGRGLGSWTARLGAAPRRNQVSAVRNLSDASLSYSGLGGWGTRVSDFLNLTKAVWRTRAYGDFFSHVLVAEGAVDISAEPEVSLWDTAALVVIVTEAGGRVTGVDGGPSPAASSILCTNAWLHDAALSHLAGSARRGG
>NC_008578.1|WP_011719370.1|568033_569044_-|ribosome-small-subunit-dependent-GTPase-A
MARRLDLVEEDVRTRPGPGSRPRSRLRPTYPDARLGQVVAVDRGRFTCAVDGRDVIAVRAKELRRTPVVVGDFVALVGDLSGRPDTLARIVRVDPRRTVLRRSADDTDPEERVIVANADQLAVVCSVANPAPQPRLVDRYLVAAFDGGLDVVLVFSKADLADPQPLLDMYRPLEVPMVVTANRQPGPELPELLRDRMTVFAGASGVGKSTLINALVPGAGRATAEVNEVTGKGRHVTTSTVVFDLPGGGRVVDTPGVRSFGLAHLDVERVVAAFPDLAPATVDCPRDCDHQPHPELDPEAARCALDSWVAAGHAAAQRLESLRRLLASLQHREADR
>NC_008578.1|WP_011719371.1|569046_570318_-|3-phosphoshikimate-1-carboxyvinyltransferase
MTTTELTGWPAPTASGRVDAVVHLPGSKSMTNRALVLAALAAEPTAIRGGLRARDTELMMAGLRSLGVGIDDAGDMWLVSPAELRGPAAIDCGLAGTVMRFLLAAATLATGEVSFDGDPRARERPLRPLLDALRQLGAELRDTGGRLPVTVVGSGHLPGGHCVVDASASSQFVSALLLVAPRADTPVTVGHVGRTLPSVPHITMTVAMLRERGVEVAGTDGSWRVQPGPIRGGTVQIEPDLSNAAPFLAAALVTGGRVRVPDWPMRTTQAGDALRDLLTAMGARCELDATGLTVTGGPVIHGLDADLRDVSELVPTLAALAALADRPSTFRGIGHMRGHETDRLAALAAELTRLGGDVTATDDGLVIRPRPLHGGVFHSYGDHRMATTGAVLGLVIPGIVVENIQTVAKTMPTFVELWTGMLR

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Crispr_ID: NC_008578_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_4

641364-641457

Orphan

Consensus_repeat	Method
CGGGCGCTCACTGCGCCCGCCGCAGCTCGGGAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_4

>merge|NC_008578|4|641364-641457|CRISPRCasFinder
CGGGCGCTCACTGCGCCCGCCGCAGCTCGGGAATGGCGGCGTGGAGAAGCCGCGGTTGCACGGGCGCTCACTGCGCCCGCCGCACCTCGGGAAT

>NC_008578|4|4|641364-641457|CRISPRCasFinder
CGGGCGCTCACTGCGCCCGCCGCAGCTCGGGAAT	GGCGGCGTGGAGAAGCCGCGGTTGCA
CGGGCGCTCACTGCGCCCGCCGCACCTCGGGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_011719442.1\|643414_643870_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_008578.1\|WP_011719438.1\|639181_639526_-\|Lsr2-family-protein	unknown	unknown	gnl\|CDD\|378714
NC_008578.1\|WP_041835308.1\|641480_642338_+\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|369882
NC_008578.1\|WP_169303183.1\|637094_638519_-\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NC_008578.1\|WP_011719447.1\|650067_650844_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
NC_008578.1\|WP_011719449.1\|652199_652778_-\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011719437.1\|638669_639029_-\|Sec-independent-protein-translocase-subunit-TatB	unknown	unknown	gnl\|CDD\|179287
NC_008578.1\|WP_169303182.1\|634215_635970_-\|thiol-reductant-ABC-exporter-subunit-CydD	unknown	unknown	gnl\|CDD\|274323
NC_008578.1\|WP_148204645.1\|645789_646587_-\|SAM-dependent-chlorinase/fluorinase	unknown	unknown	gnl\|CDD\|376645
NC_008578.1\|WP_041835312.1\|651273_651861_-\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011719439.1\|639807_641226_-\|glycoside-hydrolase-family-18-protein	unknown	unknown	gnl\|CDD\|119365
NC_008578.1\|WP_011719431.1\|629346_630603_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|225148
NC_008578.1\|WP_011719446.1\|647607_649914_-\|FdhF/YdeP-family-oxidoreductase	unknown	unknown	gnl\|CDD\|273765
NC_008578.1\|WP_083760466.1\|628205_629150_+\|biotin-dependent-carboxyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224895
NC_008578.1\|WP_011719433.1\|632542_634219_-\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|274331
NC_008578.1\|WP_148204644.1\|643883_645533_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_008578.1\|WP_011719435.1\|636030_637077_-\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|376764
NC_008578.1\|WP_041834908.1\|630926_632546_+\|divalent-metal-cation-transporter	unknown	unknown	gnl\|CDD\|334596
NC_008578.1\|WP_011719441.1\|642433_643264_+\|ZIP-family-metal-transporter	unknown	unknown	gnl\|CDD\|223505
NC_008578.1\|WP_011719445.1\|646837_647308_-\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107221

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_011719442.1\|643414_643870_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	7.65375e-19
NC_008578.1\|WP_011719438.1\|639181_639526_-\|Lsr2-family-protein	gnl\|CDD\|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	3.08997e-41
NC_008578.1\|WP_041835308.1\|641480_642338_+\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|369882	pfam08450, SGL, SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.	1.86616e-80
NC_008578.1\|WP_169303183.1\|637094_638519_-\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	0
NC_008578.1\|WP_011719447.1\|650067_650844_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	4.16014e-24
NC_008578.1\|WP_011719437.1\|638669_639029_-\|Sec-independent-protein-translocase-subunit-TatB	gnl\|CDD\|179287	PRK01371, PRK01371, Sec-independent protein translocase protein TatB.	3.50317e-36
NC_008578.1\|WP_169303182.1\|634215_635970_-\|thiol-reductant-ABC-exporter-subunit-CydD	gnl\|CDD\|274323	TIGR02857, transport_ATP-binding_protein, thiol reductant ABC exporter, CydD subunit. The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD.	9.97507e-120
NC_008578.1\|WP_148204645.1\|645789_646587_-\|SAM-dependent-chlorinase/fluorinase	gnl\|CDD\|376645	pfam01887, SAM_adeno_trans, S-adenosyl-l-methionine hydroxide adenosyltransferase. This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria. The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme. S-adenosyl-l-methionine hydroxide adenosyltransferases utilizes a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion. This family used to be known as DUF62.	1.15547e-94
NC_008578.1\|WP_011719439.1\|639807_641226_-\|glycoside-hydrolase-family-18-protein	gnl\|CDD\|119365	cd06548, GH18_chitinase, The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.	1.52971e-116
NC_008578.1\|WP_011719431.1\|629346_630603_+\|CBS-domain-containing-protein	gnl\|CDD\|225148	COG2239, MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism].	1.23819e-48
NC_008578.1\|WP_011719446.1\|647607_649914_-\|FdhF/YdeP-family-oxidoreductase	gnl\|CDD\|273765	TIGR01701, Hypothetical_protein_Rv2900c/MT2968/Mb2924c., oxidoreductase alpha (molybdopterin) subunit. This model represents a well-defined clade of oxidoreductase alpha subunits most closely related to a group of formate dehydrogenases including the E. coli FdhH protein (TIGR01591). These alpha subunits contain a molybdopterin cofactor and generally associate with two other subunits which contain iron-sulfur clusters and cytochromes. The particular subunits with which this enzyme interacts and the substrate which is reduced is unknown at this time. In Ralstonia, the gene is associated with the cbb operon, but is not essential for CO2 fixation.	0
NC_008578.1\|WP_083760466.1\|628205_629150_+\|biotin-dependent-carboxyltransferase-family-protein	gnl\|CDD\|224895	COG1984, DUR1, Allophanate hydrolase subunit 2 [Amino acid transport and metabolism].	1.45782e-93
NC_008578.1\|WP_011719433.1\|632542_634219_-\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|274331	TIGR02868, ABC_transporter_ATP-binding_protein, thiol reductant ABC exporter, CydC subunit. The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex.	2.00962e-88
NC_008578.1\|WP_148204644.1\|643883_645533_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.20112e-40
NC_008578.1\|WP_011719435.1\|636030_637077_-\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	1.24764e-95
NC_008578.1\|WP_041834908.1\|630926_632546_+\|divalent-metal-cation-transporter	gnl\|CDD\|334596	pfam01566, Nramp, Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.	2.38096e-81
NC_008578.1\|WP_011719441.1\|642433_643264_+\|ZIP-family-metal-transporter	gnl\|CDD\|223505	COG0428, COG0428, Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism].	8.6513e-12
NC_008578.1\|WP_011719445.1\|646837_647308_-\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107221	cd06464, ACD_sHsps-like, Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.	2.8559e-32

>NC_008578.1|WP_011719439.1|639807_641226_-|glycoside-hydrolase-family-18-protein
MLSRFRHTRWITRTQRHTRWSTRTHRRTGRLAPAAAVLVAAVVVPSSAAAHEPRSDGLVRAAYYTQWSVYSGFTVAGVVANGDAGRLNQINYAFINVAPNPAVSGSPIECLSGDPWADYQMPFGGATGRPSVDGTADDWSGLQGNFKQLRELKTRYPNLRIIASLGGYSWSGYFSDAALTAESRAHLVASCIDLLINGNLPGLPPGAAKGIFDGIDVDWEYPGAAGATLTNGNGNPTARPEDTRNFTLLLAEFRRQLDSAARANHHRRYLLTAALSANPTKIALLEVPQISRLLDQMDVMDYDFHGPWEAHGPTDFQSELYPSAAEVAVIGSAQQFSVDQSIDAFLRAGADRHKLLVGVPFYGHGWVGVPDGGTHGLYQTATGPSWLNGGSPTWAQLEALGYAPYRDPITGGYWLYDQASETLYVVDDPVEIGQKMHYILRRDLGGTAAWSLDGDDSAGSLGAALALGLIDH
>NC_008578.1|WP_011719438.1|639181_639526_-|Lsr2-family-protein
MAQRWQVAVVDDRTGEPATETVRFALDGVEYEIDLSRSNAARLRALLAPYVRAGRRLLRTATRNGRIRYVVPRRVPVAADPRAVRAWARAHRIPVPERGRIPVAVIEMYHAAGH
>NC_008578.1|WP_011719437.1|638669_639029_-|Sec-independent-protein-translocase-subunit-TatB
MPFDLSTAKLLVLGLLALVIFGPERLPHIARDAARMLRQLRGLVGQARNELQAELGDVRHIVNDLGLSDLDPRYLIRRHLLDDQDSRAPVRGGPLPPPSHQGGVAMRSDGPPPFDPEAT
>NC_008578.1|WP_169303183.1|637094_638519_-|cytochrome-ubiquinol-oxidase-subunit-I
MSHVRLRGVTRPEVLVALFLARWQFAIVTIFHFFFVPVTIGLGVLVAVLATLAHRHRGSDWERLTRFFSHIFLISMAVGVVTGIVLEFQFGLNWSRYSVFVGNIFGAPLAIEGLLAFFLESTFIGLWVFGRDRLPPRVHLATIWLVSIGTLLSAFFILAANAWMQHPVGYRVENGKAVLTNFWAVLGNSTLWWSFAHTVFAALATGGALMLGIAVYRSRRDSDDPPSRLAFRKAAMLAAGVTAAAGILTAVSGDGQARLMDTQQPMKMAAAEALYDTTRGASFSLLTIGDLSGNPIFQIRVPGLLSLIATLNPEGEVLGIHQIQQAEQARYGSGSYVPVIWLTYWSFRIMVGAGILLVLLPLWILWRMRRRTGFEGRWLQRIALAGIALPLVANTAGWIFTEAGRQPWIVYGLMTTASGVSTVPVADVAATLGSFVAVYTILGFIAAVLIARAARRPFVEPSQFGEDEVPELVY
>NC_008578.1|WP_011719435.1|636030_637077_-|cytochrome-d-ubiquinol-oxidase-subunit-II
MSFGVLDTTWFSLIGLLWAGYLFLEGFDFGVALITPLVSKDEIDRRMCLNSVGPFWDGNEVWLIVAGGATFAAFPLWYARLFSGFYLALFLILLALIARGVSFEFRNKDHRPAWRRTWDWANFLGSLIPPAVWGVAFTNLVVGLPLDSGGVYRGGLAGLLHPIAVLGGAATVALVSFHGANFLLLKTSSGLAHRTRSVAVPLGVAATLLTGAVVLAVALTRGKALPEALPGVVPLAMAVAGVAGVAAGTFLVARARDGAAFAATGGSLLLTMGAVFARMFPTVFPDFHHPAHSVTIAAAASGHYTLVVMTIVAAIFTPLVLAYQGWTYWVFRRRLMRPTTGSGATGSA
>NC_008578.1|WP_169303182.1|634215_635970_-|thiol-reductant-ABC-exporter-subunit-CydD
MAARPRYPPTVRILLDLPAVRRGIVVAVITGVAVVAGMYLQALALAHLLDSFFTRRHTASASTWVLGLFAGIALRAGAGFSADQYANWVVVRAKEQLRTRFLTSAMHEAISQHTDPIRIAVLASRGLDGLDGYLGRYLPSLVSLVVTPPLLLGAVGWLDWPSLLIVFVPLLLFPVFGVLVGRSTTQLATRRWNITARFAAQVADTFNGLPVLRAFGLTAQRRNHLTALEQQLETATLASLRLAFLTALVLDTLAAVAVALVAVPLGLRLIYGHVSLVSALTVLVITPEILAPLRNASAQFHETAEAAQALDEIAAAFRGALGNTTDADLSNRLPNALPRSAAGGSPDPGNQTIRLSGIVVRGDRQRDRLRLEALTLRPGTVVVVVGPNGAGKSTLLQVVAGLRVPDAGHITVGDAVLSPAELTTWRRFIGYLPQPPAIIPGTVADNLRLARPDATDAELYDALVAAGAARMVERFPQALETRIGPGGRPLSAGERQRLGLARILLRRASLYLLDEPTEHLDHDSEDGILATLAHHLTGKTALIVTHRPALTQLAHVVVELPGTDGTVSLRFPLPSSASRTVDLP
>NC_008578.1|WP_011719433.1|632542_634219_-|thiol-reductant-ABC-exporter-subunit-CydC
MSASPPPTETALPRLWRRVEWRTCLKAVAISWTTVGSGIGLMTMAGWLITDASLRPPILALAVAAASVQSLALGRGVGRYAARLVLHAAALRYLGRIRLWLYDRLEPLVPAAVPRTGEVVNRLVTDADVVANGRIRGAAAITDAVGAWLIGTLAAIAIQPVLGMIVAAGTAAAQGIALWSTTVHERAEQRLSEARALLNAQVFEAFSALPELLVYDRSDVLDTVVRHATAETRPHEVRHALTVGLTRMLISIISGGTLVLVLLIGRHLAARGAINGSSVAAAAFLVLAVGEVCLALPDGLQNIGRARGAARNLSAVASRPLPSREPAVAGVPPTRPAQLLARDIVVRRSQQADSVSPATGVTEFRYPTVHVPPRARLVVTGPNGSGKSTLSYVLLHFLEPLSGAVMLGDVPLHTLRRTQIAEVVGWMPDEVYIFTATVRDNVRLAAPTASDDACKTALSRVGLAQWLTSLPNGLDTILGAGGRQLSSGERQRLGLARLLLTAVDIVLLDEPAAHIEPHDVPRLLAEIDAEFTEKSLVIMTPEGIDIPLRADATIVLGR
>NC_008578.1|WP_041834908.1|630926_632546_+|divalent-metal-cation-transporter
MEVRPTAGQAVLDDAHIGDIRGALGSIRADALTERPTWRRRLLTLAAILGPGVIVMVGDNDAGGVATYAQAGQDYGYSLLWVLLLLIPVLIVNQEMVVRLGAVTGVGHARLIVERFGRGWGWFSVGDLFVLNFLTLATEFIGIALAADYIGLSKYLVVPIAAVVLVLITASGSFQRWERSLFVFIAVSLLQIPMLLLAHPHWASIGRHLVVPGIAGGVTSNAVLLIIAIVGTTVAPWQLFFQQSNIIDKRITPRFISYERADTVIGSIFVIIGAIAIMVTAAYGAAGTGGYGHFTDAAGVAHLLRQHSPVLGAIFAVVLLDASIIGAAAVTLSTSYAFGDVFGIRHSLHRSFRDAKEFYLSYIGLVAAAAAIVLIPGAPLGLITTSVQVLAGLLLPSASVFLLLLCNDRHVLGPWTNPRWLNVVTGVIIGVLLLLSATLMVTTLFPEVPIVPLLIGLSTGLVVLGASGWLVARVSQRGRPSGQAGPPVYGDKQTWRMPSLAVLPPVEWSTWTKISMVALRGYLILSAVLLVVKAIRLAH
>NC_008578.1|WP_011719431.1|629346_630603_+|CBS-domain-containing-protein
MRLSAVIRRPVVTRSGQHVGRVVDVVIRLRDPGYPKVVGLVVDSGRRRIFVPAGQVAAVQSTRIMLAGDAVDLRPFERRRGELLLRADLLGHRFIDVSHAELVRAFDIELASGPDGWEVRALDTRRLRRWWPWRRGPAAQVRDWKDFEPLLGHIPTTHRRAARRLRRMRAADLADLLEEASAGERREILQHVHGDSELEADVFEELEPDIARRLLADKSDSDIADVLVHMRPDDAADALQDLPAERRHGVLDRLPAEYRTKLLALLHFHPTSAGGLMNVDVLTVSETMTVADALAVVAAATTVQPELAGVVHVIDAENRLIGVARVARLVQASPQAEIGTIMDADPVRVNATTDIVDLAILMADYDLTTLPVVDESGRLLGVVTVDDVLESIIPEEWRRREPPPHPEYRPEPAEDQSA
>NC_008578.1|WP_083760466.1|628205_629150_+|biotin-dependent-carboxyltransferase-family-protein
MADAAENTVLVESAGARTTIQDLGRVGFAHVGVPRSGVADWFSARLANALVGNVPSAPLLEATLIGPRLRFRRAALVAVTGAPAPVTVDGAAVPPFQPVAIPEGGVLQIGTMRSGVRAYVAVRGGVAAPLILGSASTDTLSGLGPSPLTAGAELPLGNADQCPAPPADDEVRELAKNAAAGVLLAVREGRVRFLPTVEGDPAQLAGEYRVRPESDRVGVRLAPIGKPPEATRPAETMGMVGGAIQLPPDGNPIILLADHSVTGGYPVAGVVIHADLPLVAQARPGDRVRLVAVSEEEAHAALVARHLVLARVER
>NC_008578.1|WP_041835308.1|641480_642338_+|SMP-30/gluconolactonase/LRE-family-protein
MSTAEQFTEPAAFHAEGPVWSPYGLRWVDMLAGDVLGVVGGVVRRRHVGSVAAALRPRRQGGMVIAVERGFALCDGDPLDASSALFPLPELWTDRGVRMNDGGCDPAGRFYCGSMAYDQAPGRGALYRLDPDHSSHLVLPNVTISNGIDWSPDGSLVYYNDSPTHRVWCFDDDGLSGLRNRRVFAEIPEDLGVGDGLTVDADGGVWVAIYGGGQVRRYRPDGVLDGVVELPVTQVTACAFGGDDFGELFITTSRENVADGEQPEAGAVFRIRPGVHGRPPRPYAG
>NC_008578.1|WP_011719441.1|642433_643264_+|ZIP-family-metal-transporter
MSPERVALLGAIAGVTIFIGLPVGRTRKAIPATKVLLGGLAAGILVFLLWDVLEHAWEPIDQALGDHHYASAIGNGAVMTAGFCLGMLGLIGYEVWMSQRARRRAPSLGPGTAAVAELEPSLLGTPARRLAFFIAVGIGLHNFSEGLAIGQSAARGELTLATLLVIGFATHNATEGFGIVAPLAAEAVRPSWGWLGLLGLIGGGPTFIGTLVGQSVVNDTLSIAFLALAAGSILYVVVELIAAGRKSGHKVLLSTGIVLGVVLGFLTDAIVTAAGA
>NC_008578.1|WP_011719442.1|643414_643870_-|MarR-family-transcriptional-regulator
MPSAQKSAAELVELATDLRVAAGRLLRRTRAAAAGGLTPSQLAVLTTLEEHGQLRLGELAHREGVAPPTMSRTVDALLLLGLVARRPDPADARSTFVELTTAGRAVIRRTADRRTRLLAEHLRRLSTAELRAIRDVLPVLHRLADDLGSDE
>NC_008578.1|WP_148204644.1|643883_645533_-|MFS-transporter
MLMATINSSIVMISLPAIFRGIHIDPLAHGNVSYLLWMIMGFLLVTAVLVVSVGRLGDIYGRVRIYSMGFAIFTAASIALALDPLTGGGGALWLIIWRVVQGVGAAMLFANSAAILTDAFPPDRRGMAMGINQVAAIAGSFIGLIAGGLLSEVDWRLVFFVSVPFGLLGTIWSYASLREIGERSPARIDVWGNLTFGLGLTAILVAITYGIQPYGGSTMGWTNPWVDAGLVGGAALLAVFCIIETKVPEPMFHMQLFRIKAFSAGNLAGWLASIARGGMQFMLIIWLQGIWLPLHGYKFADTPLWAGIYLLPLTIAFLAAGPISGYLSDRFGARAFATGGLLIVAASFAGLMALPTNFPYWEFAALLAINGIGSGLFSSPNTTAIMNAVPASTRGAASGMRSTFFNSGTSLSIGIFFSLMILGLAHNLPHTLTSGLEAHHVPSNIATAIGNAPPVASLFAAFLGYNPIQTLLGPHVLSTLPPTDAAVLTGRTFFPSLIAGPFHDGLVVVFAMAIAMSVIGAVASLFRGARYVHDEAERRPTATPAAQGA
>NC_008578.1|WP_148204645.1|645789_646587_-|SAM-dependent-chlorinase/fluorinase
MGLMPWISLLTDYGYEDAFVAICHGVIGRLAPDVRILDITHAVPPGNVRRGATLLAEAIPFLPDGVHVGIVDPGVGTARRPIVVETPQHLFVGPDNGLLLPAAEAAGGIRRAFRLTNSALWLHPVSATFHGRDIFAPTAAHLATGTPVDLVGPELDPQQLVRLPSPVARLHGEMIDAEISSIDRFGNVQLACGDIAGWALGQPLVVEGGGAQVPAVRATTFGAVAPGETLVYVDSAGRLAVAVHGGRADARLSVHEGDLLRIRPA
>NC_008578.1|WP_011719445.1|646837_647308_-|Hsp20/alpha-crystallin-family-protein
MALRFDPFREFDRLTEQLLGSALGSVRTPRFMPMDLYRAGDHYVLHADLPGVDPGSVNVSVENGILTIEAERTPRTDENLQWLASERFTGKFMRQISLGEGVDTDHIAATYENGVLTVTIPVAEKAKARRIEVTRADSPRVIESSAASVQQPASVS
>NC_008578.1|WP_011719446.1|647607_649914_-|FdhF/YdeP-family-oxidoreductase
MSRRARQGGEPAQHAAGLPAVARTVEITLREAGVGRGLRALAAVNQRGGFECPSCAWPDAEPRHRIEFCENGAKAVAWEATRRTIGAAFFAEHSITDLLSRDDHWLESRGRLAEPLVAEPGDDYYRPVSWDAALDRIAAALRGLDTPDQAVFYTSGRTSNEAAFLYQLLARRLGTNNLPDCSNMCHESSGVALSQTIGVGKGSVTLDDIAHYADLIVLVGQNPGTNHPRMLSSLEEAKRRGARIVAVNPLPEPGLRSFRNPQRVSGLLGRGTPIADLYLPVRVGGDLALFQWVNRRLVERDARFGGGENILDHGFIRRYCAGFEDAAQFWAGLDPRRLAAESGLDDEAVNRFVDEVIAARSVVLCWAMGITQHRNAVPTIREFVNFLLLRGNFGRPGAGACPVRGHSNVQGDRTMGITDKPSPAFLERLQAEFGFAPPTQPGLDVVEAIRAMYDGRIRFFMGLGGNFAVAAPDTMRTAEAMRTCALTVHVATKLNRTHLLRGTTSFLLPALARSDRDESAGRRQMVTIEDSMGIVRASIGHLTPVSPHLRSEVSIVAELGARIFGDADVVPWRELGRDNRRIRERIARVVDGFADVEDRLNAGGSFVLPHPVRDERRFPTADGRAHFTVNRAQPLEIPPGCLLLQTIRSHDQFNTTIYSYHDQYRGVVGDRRVVFVNPDDLSRLGIAPRSRVTLVSIWSDGERRLRDFTAIPYPTPQGCAAAYFPEANPLVPLDSTALESNTPTSKAIVIRLEPQSVTPDAEVAAPRR
>NC_008578.1|WP_011719447.1|650067_650844_-|phosphatase-PAP2-family-protein
MAGDKTKTLVQLLDRLIARMGRRRWYLLIGVLIAYALLTMAVIFGSPLDALDHRAAAMDLAQRWPDVKPWILHYVMIGQRAPSAAAAGALVIYLSWRRRTAQPLVMLAVGLALLNVSVGAVKVSTGRLGPLLTTHPHAVFDGGDIFPSGHTSNAVVVFGILVLLTAPTYRRLVTAVAVFVAVTVGLSTIFLDTHWVTDVLGGWLAGSLILLILPEVTLVTMRALHGARARWHIWRTFRRTGGPPEDWRDHSQPELAKR
>NC_008578.1|WP_041835312.1|651273_651861_-|hypothetical-protein
MSATPFLVLAVVAGLVASAVLIWHASFAAFTATTSNSNNQWSSGTVTLSDDDTNQAMFSATGLKPGSTGSHCITVQYGGSLPAAVKLYIAPGGLTHSAGSSPYLSDYLTITVEEGSGGNFGSCTGFTPSTTIINAVHLTTIASTYTNFATGAGTWAPSGAANMVYRFTYTLDSSAPNTVAGQTDTATFTWEADNT
>NC_008578.1|WP_011719449.1|652199_652778_-|hypothetical-protein
MIQTPAGSSQATRAPTLVIRVRGTATCRTVTYSASGSVRGGDATPHRRTPSATRRAIGSALALALIGIASACSAHHAKPNPTAGASPSAKIAAEANRNHVTVDINKGEIVRVTIPPLYQNDGQVTLYNVDPPGSNVVAPVPGAPGYFRGMVPGSVTIRAQQVPPCATQSPSPTSGCDTRPADIGLLTITVKG

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Crispr_ID: NC_008578_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_5

1280366-1280453

Orphan

Consensus_repeat	Method
CTCCGGCTGCCGCCCACCTGCGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_5

>merge|NC_008578|5|1280366-1280453|CRISPRCasFinder
CTCCGGCTGCCGCCCACCTGCGTGGCGCACTGACCGCGTACGCCAGAGCGTTTGGCGCATCAGTCTCCGGCTGCCGCCCACCTGCGCT

>NC_008578|5|5|1280366-1280453|CRISPRCasFinder
CTCCGGCTGCCGCCCACCTGCGTG	GCGCACTGACCGCGTACGCCAGAGCGTTTGGCGCATCAGT
CTCCGGCTGCCGCCCACCTGCGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_011719997.1\|1289478_1290633_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NC_008578.1\|WP_148204554.1\|1283875_1284958_-\|lytic-murein-transglycosylase	unknown	unknown	gnl\|CDD\|381602
NC_008578.1\|WP_148204667.1\|1273484_1274444_-\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|236489
NC_008578.1\|WP_041835493.1\|1286714_1287539_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NC_008578.1\|WP_011719989.1\|1281557_1282418_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_008578.1\|WP_011719986.1\|1278891_1279596_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl\|CDD\|187594
NC_008578.1\|WP_011719981.1\|1274454_1274898_-\|DUF3099-domain-containing-protein	unknown	unknown	gnl\|CDD\|378630
NC_008578.1\|WP_011719987.1\|1279595_1280363_+\|enoyl-ACP-reductase-FabI	unknown	unknown	gnl\|CDD\|236124
NC_008578.1\|WP_011719982.1\|1274919_1275132_+\|dodecin-domain-containing-protein	unknown	unknown	gnl\|CDD\|377810
NC_008578.1\|WP_011719978.1\|1271104_1272988_-\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|225922
NC_008578.1\|WP_011719983.1\|1275162_1276581_-\|peptidase	unknown	unknown	gnl\|CDD\|223389
NC_008578.1\|WP_011719990.1\|1282442_1282874_+\|NfeD-family-protein	unknown	unknown	gnl\|CDD\|224501
NC_008578.1\|WP_011719996.1\|1288005_1289328_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_008578.1\|WP_011719984.1\|1276582_1278100_-\|TldD/PmbA-family-protein	unknown	unknown	gnl\|CDD\|223389
NC_008578.1\|WP_011719994.1\|1286219_1286432_-\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011719979.1\|1273139_1273478_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011719988.1\|1280593_1281394_+\|transglycosylase-family-protein	unknown	unknown	gnl\|CDD\|381607
NC_008578.1\|WP_011719991.1\|1282877_1283834_+\|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl\|CDD\|223407
NC_008578.1\|WP_083760525.1\|1285086_1285986_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NC_008578.1\|WP_011719985.1\|1278236_1278623_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_011719997.1\|1289478_1290633_-\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.56217e-79
NC_008578.1\|WP_148204554.1\|1283875_1284958_-\|lytic-murein-transglycosylase	gnl\|CDD\|381602	cd13399, Slt35-like, Slt35-like lytic transglycosylase. Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).	7.13829e-29
NC_008578.1\|WP_148204667.1\|1273484_1274444_-\|quinolinate-synthase-NadA	gnl\|CDD\|236489	PRK09375, PRK09375, quinolinate synthase NadA.	1.41491e-174
NC_008578.1\|WP_041835493.1\|1286714_1287539_+\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	2.57418e-58
NC_008578.1\|WP_011719989.1\|1281557_1282418_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	2.3059e-93
NC_008578.1\|WP_011719986.1\|1278891_1279596_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl\|CDD\|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	9.50062e-121
NC_008578.1\|WP_011719981.1\|1274454_1274898_-\|DUF3099-domain-containing-protein	gnl\|CDD\|378630	pfam11298, DUF3099, Protein of unknown function (DUF3099). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	6.7919e-23
NC_008578.1\|WP_011719987.1\|1279595_1280363_+\|enoyl-ACP-reductase-FabI	gnl\|CDD\|236124	PRK07889, PRK07889, enoyl-[acyl-carrier-protein] reductase FabI.	4.0086e-167
NC_008578.1\|WP_011719982.1\|1274919_1275132_+\|dodecin-domain-containing-protein	gnl\|CDD\|377810	pfam07311, Dodecin, Dodecin. Dodecin is a flavin-binding protein,found in several bacteria and few archaea and represents a stand-alone version of the SHS2 domain. It most closely resembles the SHS2 domains of FtsA and Rpb7p, and represents a single domain small-molecule binding form.	2.08455e-30
NC_008578.1\|WP_011719978.1\|1271104_1272988_-\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	4.42275e-134
NC_008578.1\|WP_011719983.1\|1275162_1276581_-\|peptidase	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	3.09963e-32
NC_008578.1\|WP_011719996.1\|1288005_1289328_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.87357e-63
NC_008578.1\|WP_011719984.1\|1276582_1278100_-\|TldD/PmbA-family-protein	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	1.65253e-93
NC_008578.1\|WP_011719990.1\|1282442_1282874_+\|NfeD-family-protein	gnl\|CDD\|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	2.50742e-20
NC_008578.1\|WP_011719988.1\|1280593_1281394_+\|transglycosylase-family-protein	gnl\|CDD\|381607	cd13925, RPF, core lysozyme-like domain of resuscitation-promoting factor proteins. Resuscitation-promoting factor (RPF) proteins, found in various (G+C)-rich Gram-positive bacteria, act to reactivate cultures from stationary phase. This protein shares elements of the structural core of lysozyme and related proteins. Furthermore, it shares a conserved active site glutamate which is required for activity, and has a polysaccharide binding cleft that corresponds to the peptidoglycan binding cleft of lysozyme. Muralytic activity of Rpf in Micrococcus luteus correlates with resuscitation, supporting a mechanism dependent on cleavage of peptidoglycan by RPF.	2.73732e-25
NC_008578.1\|WP_011719991.1\|1282877_1283834_+\|SPFH/Band-7/PHB-domain-protein	gnl\|CDD\|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	6.77477e-64
NC_008578.1\|WP_083760525.1\|1285086_1285986_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	8.26663e-30
NC_008578.1\|WP_011719985.1\|1278236_1278623_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	5.05031e-10

>NC_008578.1|WP_011719987.1|1279595_1280363_+|enoyl-ACP-reductase-FabI
MGILDGKQLLVTGVLTDASIAFHVARLAQLEGAEVLLSSYGRAFRLTERIAGRLPKPAPVIELDVTNAEDLAALPDRVRAHLTRLDGVVHAIAYAPEGALGGKFLQTPWEDVATALHVSAYSLKALATAATPLMGEGSSLVGLDFDASVAWPLYDWMGVAKAALESCARYLARDLGPRGIRVNLVSAGPVRTVAAKGIPGFESLAAIWTERAPLSWDLSDGEAPARAVIALLSDWFPKTTGEIVHVDGGVHAVGA
>NC_008578.1|WP_011719986.1|1278891_1279596_+|3-oxoacyl-[acyl-carrier-protein]-reductase
MARCVLVTGGSRGIGLAIAQAFAADGDHVAVTYRSSEPPAGLFAVRADVTNSDEVEKAFDAVEAEFGPVQVLVANAGITRDTLLLRMTEDDWRTVLETNLTGAYRVAKRAVRSMLRARSGRLLFISSVVGLLGSAGQANYAATKAGLIGFARSLAREFGSRGITANVVAPGFVDTEMTRVLGDERRAEILKQVPLGRYATPEEVAGVVRFLASDAASYITGAVIPVDGGLGMGH
>NC_008578.1|WP_011719985.1|1278236_1278623_-|STAS-domain-containing-protein
MTTMTADSLGSVSTTVLADGIVVRLGGSLDAASLPELRAALLTERPEGRDDVLVDASRVTEVHERALAILVAAVSWAEQTGGRLQFAAMSPALAETARYFAVHDLLPLLPGPGGRAERAALTVAGDGC
>NC_008578.1|WP_011719984.1|1276582_1278100_-|TldD/PmbA-family-protein
MPADHRAIEPAFLALPLTRLADAALDEARRLGAQHADVRVERIRSQHLRLRDGRLEGRIDDEDIGFAVRVIADGTWGFAAGVDMTPEAARAVAGRAVEIARAAKAINREPVELAPEPVYRDAIWISAYEVDPFSVPDNEKIELLAERSRRLLASPHVDHVDAGVAQVLENKFYADTAGTSTIQQRVRVMPTLTAVAVDETTGRFETMDTIASPAGRGWEYLTGTGFDWESELAQLPEWLAEKLVAPSVEPGRYDLVIDPSNLWLTIHESIGHATELDRALGYEAAYAGTSFATFDKLGSLRYGSPIMHVTGDRTAVHGLATIGYDDEGVAAQQFDLIRDGILVGYQLDRRIARLKGFPRSNGCAFADCAAHMPIQRMANVSLQPAPDGPSTQELIGMVDRGIYIVGDKSWSIDMQRYNFQFTGQRFFEIRGGRLTRQIRDVAYQATTTDFWGAMEAVGGPQTYVLGGAFNCGKGQPGQIAAVSHGCPSALFRGVRILNTVQEGGR
>NC_008578.1|WP_011719983.1|1275162_1276581_-|peptidase
MAAFSPQDAAETILERARGTCDVDGCIVLVDEDSSANLRWANNTLTTNGVTRQRRITVIATVPQHDGAGTGIAAGVVSRSVTADTDVTELVDAAVGAARSSTPAEDAAPLVEPGDRNSPAWSEPPHETSGGVFTDLVAGLGAELSRADKEGRLLFGFAEHQMRTTYLATSTGVRLRHDQPTGKIELTGRSTDHRRSAWVAAGTRTFQDVDIAALHADIAQRLGWAERSIELPPGRYETLLPPTAVADLMIYLYWSAGARDAHDGRTVFSKPGGGTRVGDQLTGVPLTLRSDPFEPGLECEPFVIAHTSTGESSVFDNGLPLGPTAWIDRGRLAALLQTRYSARLTGLPVTPAIDNLILTHADGQATLSEMIASSRRSLLVTSLWYIREVDPQTLLLTGLTRDGLYLVEDGEVVAAVNNFRFNESPVDLLARVTEGGGTVPCLPREWNDYFTRTAMPPLRVADFNMSTVSQAS
>NC_008578.1|WP_011719982.1|1274919_1275132_+|dodecin-domain-containing-protein
MTDRTYRITEIVGTSRESVQQAIRNGIKRAAQTLRHLDWFEVTQIRGNLINGEVDHFQVTLKVGFRLEDP
>NC_008578.1|WP_011719981.1|1274454_1274898_-|DUF3099-domain-containing-protein
MGVPVGTVKSVTGWGRSHRTPVPLVTTARPPHSVELSHRFRRYVFSMAVRTAAVVLAIFVFHGWMRLVAIVAGVALPWLAVVAANAGPSRDEQEPLFLRPGEGGRAAGSEEARQISPSTGRHDDADRDSPMNAHLPEATTNRMDNDR
>NC_008578.1|WP_148204667.1|1273484_1274444_-|quinolinate-synthase-NadA
MTSWAAEVRRLADQRNAVILAHNYQLPEIQDVADHVGDSLALSRVAAEHPADVIVFCGVHFMAETAKILSPDKTVLLPEPEAGCSLAASITADDVRAWKATHPDGVVVAYVNTSAEVKAESDICCTSSNAADVVRSIPEGVPIFFIPDQFLGAHVRRVTGRDMDVWAGECHVHAEISPAELRRRIADEPDADILIHPECGCTTTALYLAGAGDLPRERTKILSTGGMVAYAEQTQARRVLVATETGILHQLRRRAPGTDFQPITDRAVCPYMKMITPEKLLRSLRDGVFEVDVDPEIAARARRSVERMIQIGSPSRGGE
>NC_008578.1|WP_011719979.1|1273139_1273478_+|hypothetical-protein
MKRRVAAAAVIALGCMLASCKQTAGLARQELVVQFRPGATQADHERVWRACPGGPRIVREPLDTTSSYAATLLNNVRYRVDTASNYDLAQLIQCLQRDPSVAGYSITGGDNQ
>NC_008578.1|WP_011719978.1|1271104_1272988_-|glycoside-hydrolase-family-15-protein
MSRPIEDYGLIGDMHTAALVSRGGSIDWLCFPRFDSAACFAALLGDEENGHWTIAPAAGGDATRRQYRGDTLILEHEWVTPEGTVRLIDFMPPRDELPDVVRIVEGVSGRVPMRSTLRIRFDYGHIVPWVTRHDGVLGAIAGPDALWFRSPVPTKGVDFSTVSEFTVVSGDRLAFSLTWNPSHWPPPRSPDPTRALRDTEKYWQKWISRNAFDRESPYYEAVVRSLIVLKALTYRPTGGIVAAATTSLPEQIGGSRNWDYRYCWLRDATMTLHALLDAGYEEEAKAWREWLIRAVAGDPKDMQIMYGIDGRRRLLEYEVPWLAGYENSRPVRVGNAASEQFQLDVYGEVMDALDLARTAGLAPDEQAWSFQRVVMDFLEGHWRDPDNGIWEIRGDPQHFTHSKVMAWVAVDRVIRGVERWGLTGPVDRWKALRDEISRDVLEHGYNAELGCFTQVYGSRELDAALLLIPAYGFLPAKDERVLRTIEAIQRELVVDGLVRRYRTSNDTTGIDGLAGEEGVFLACTFWLADALCLAGRTAEAREIYERLLSLRNDLGLLSEEWDVARRRQVGNVPQAYSHIGIVNTACNLAGQTGPVHNRAQQYTVGAWRRLRSIPQVLSRVAANFGEW
>NC_008578.1|WP_011719988.1|1280593_1281394_+|transglycosylase-family-protein
MGAHRYRGPRHARPKGPRHAKPAPPSVAGRTVAATGFAVAMLTGELASAASASAVGSDVWAALRMCESSGNYHINTGNGYYGAYQFDLRTWRGLGYSGLPSDAPPAVQDEAAQRLYAQRGWQPWPACSRKLGLVDDRASRSANRPPLDPPQGVDPPQGTDTATAEVVRAAAQDTGPAVRSGPAGPAPVPRLPWNGHYLTVRDVYQVRDDVRLFQQAMVAHGYHIAVDGRYGPQSAAATTAFERAHHLHVEDPGVVGPQVWGALFGT
>NC_008578.1|WP_011719989.1|1281557_1282418_+|ABC-transporter-ATP-binding-protein
MVEVWHAVRGSAHDPALFGVRVAESAGDVVVRLRSASVVRGGATLLADIDWEVRGGEHWVVLGPNGAGKTTLLKLLSTQWHPTTGEVEVLGERMGAVDVFELRPRIGFSSAALADRLPAGERVRDVVLTASYGTIGRWREQYDEADFARAHAVLARLGVGHLRDRRYGSLSEGERKRVQLARALMSDPELLLLDEPAAGLDLGGREDLLAQLAHLLQSPTAPATVLVTHHVEEIPRGITHGLLLRAGRIVARGPLTEVLTAANLSVTFARDLVVEAHDGRFFARSI
>NC_008578.1|WP_011719990.1|1282442_1282874_+|NfeD-family-protein
MPMWLIWTIVAVACAGAEALTLTLILGFIAAAAALTLVAAVLGAPIVAQLLVFVGSAAALLGVVRPIARAHLYTPPALRTGVDALVGQRGLVVERVDAHHGQIKIGGELWSARPYVDGQCYEPGTTVEVVKIQGAIALVFGTE
>NC_008578.1|WP_011719991.1|1282877_1283834_+|SPFH/Band-7/PHB-domain-protein
MPAAVIALIVIAIFVLIVLGRSVRIVPQARAGIVERLGRYHRTLAPGLNVVVPFIDRIRPLIDMREQVVSFPPQPVITQDNLVVGIDTVLYFQVTDAKAATYEIANYIQAIEQLTVTTLRNVIGGMDLEKTLTSREEINAQLRGVLDEATGKWGIRVNRVELKSIDPPLSIKDSMEKQMRADRDKRAAILLAEGQKQAQILTAEGEKQAAILRAEGQAQAAVTQARAEAEAQALRANGQAQAIGTVFRAIHEGKVDPDLLAYQYLQVLPQIAQGDANKVWIVPSEISKALEGVGNLFGRAAAPGNPDGAAAQRTTSPE
>NC_008578.1|WP_148204554.1|1283875_1284958_-|lytic-murein-transglycosylase
MPIGGELGHRARRWLATGACVLALSPLLVPTAADAESAAQAQREAAAIAAQVQALQPQVTAALAAYEAALDGVARSVSATVADRRVYEALQAQADQAAATYAAGIAALYEAGGPLGIYAALLTTGVPPDLRHLPYVSGVLSRQAAWAETTRQFASAAKQRLDADEASIDTELDNAATIQQRYLVLQGLLDRAQAILDAATARARALAAWESAAAALAAVRVAADQAGVDAAANAVAEPIPDAYRAWYQAAAKTCPGLPWQVLAAIGQVESHHGQGTMVSAAGALGPMQFLPATFARYATDGNGDGKADIWNPADAIFTAARYLCANGAGQGEAGLQAALWNYNHAEWYVQLVLAIAAKIR
>NC_008578.1|WP_083760525.1|1285086_1285986_+|sulfite-exporter-TauE/SafE-family-protein
MALSAQPRRPPRGRGVHPAGLPGRNRPPPASAVRATPYARAVPALNLLNVAGVFGAGIVAGTVNTIVGSGSLLTFPVLLGVGLSPLAANVTNTVGLVPGSVSGALGYRRELRGQRRRCLRLAVSSLIGGCVGAVLLLVLPSRSFERIVPFLVLMASLLVLVQPRLGRIVARRNSARGHDPQRTDPILDTTNGLTAVYGGYFGAAQGVILMALLGIFVPEDLQRLNAVKNVLAALVNGIAALLFAFFAPVAWWFALVEALGAVVGGQLGAVVGRRIPPRLLRAVIVIVGLVVAAKLFASW
>NC_008578.1|WP_011719994.1|1286219_1286432_-|hypothetical-protein
MNDLDLFSRRRGGLMRGVRGAVAWFGSGFVVGMALALLFSTLVRALIIAAAIVIVLLALIRTAIGGRRPY
>NC_008578.1|WP_041835493.1|1286714_1287539_+|RNA-methyltransferase
MAEVVPIYDPQDPRLADYRALTDVELRKRVEPAHGIFIAESALVIQRALAAGYRMISAFVSDRWLDELADQLSSVEAPVYVGAPEVLQSVTGFHVHRGALAAFARRPLSSVEEILRTSRRIVVLEDVNNHTNLGAVFRCAAALGMDGVLLSPRCADPLYRRSVRVSMGAVFAIPYARFDTWPDELTGVSAAQFRLLALTPDPAATDIRTLRVAAGERIALMLGAEGPGLSKQALDRAELRVRIPMHAGVDSLNVAAAAAIACFVVGEPAPPRLD
>NC_008578.1|WP_011719996.1|1288005_1289328_+|GGDEF-domain-containing-protein
MTVLPRAWALATMPRPARHFVLAVDALYLMALIAGGMRTSFRTTDLVTAGVLTGLAIVSIETSLRFVWHRPHGGGSTNDLLAVWTLPVALLLPPLYSALVVVPVLLFTQVRVVRRAPVKLIFSIASTGIAGFVAASVHEAYFGSGTVWTPETLVGSPRALAATASCVLVRYVVNLLLVGQVVALTKPKTSPFALLKNRENLGISAAEACTGVLVALACATALYAVPLAIPPVLVFQRTLLIAELRHAARTDPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRPRDFVGRFGGEEFVILLAGSDLEQAAVAAERVRQHIAHLTVDTPLHGDPVSVTVSVGVAAFRENGHSVLELLDAADAALYEAKRAGRNCVRVATGVRQQVLDLTGDTPRLIDLRTERQPIVD
>NC_008578.1|WP_011719997.1|1289478_1290633_-|MFS-transporter
MDPVLLAPPRLSAQRARIVIATIFAVHGVVFATFATRIPWLQDRLGLSAGSLGAALLFGAIGGLLGMPFASRLLHRFGGRRTTRVLMAAWCIAGALPVLAPNLAALIPLLLLYGMTSGMADVAMNAQAIPVERDLGKSIMSGLHGMWSVGGIVGSAVGVAAAHAGLDARIHLAIVDAALLVVALGATSKLPVNLPDAAEPPPKPFVVPSRGVLLIGLVAFCAIFAEAASSDWCAVYLTRITGADPGIAAASYTAFACTMAAARFGGDFAVRRLGLRSTVRIGGVVGTLGALLVVAAFAIAPTIVGFALIGLGIAVTFPLAVAAAGHADPIPARGISGVATISYGAGIAAPGIIGGIADATSLQVSFGVVAAVIAFIAVGARYLR

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Crispr_ID: NC_008578_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_6

1286553-1286650

Orphan

Consensus_repeat	Method
ATGGACGCCGATCCGTCGCTGTCTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_6

>merge|NC_008578|6|1286553-1286650|CRISPRCasFinder
ATGGACGCCGATCCGTCGCTGTCTGCCAGGGAAGGTGCGGCCCGCCTGGAGTGACCGGGCTGCAGCGTCGCCATGGACGCCGATCCGTCGCTGTTGCA

>NC_008578|6|6|1286553-1286650|CRISPRCasFinder
ATGGACGCCGATCCGTCGCTGTCTGC	CAGGGAAGGTGCGGCCCGCCTGGAGTGACCGGGCTGCAGCGTCGCC
ATGGACGCCGATCCGTCGCTGTTGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_011719997.1\|1289478_1290633_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NC_008578.1\|WP_148204554.1\|1283875_1284958_-\|lytic-murein-transglycosylase	unknown	unknown	gnl\|CDD\|381602
NC_008578.1\|WP_041835493.1\|1286714_1287539_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NC_008578.1\|WP_011719989.1\|1281557_1282418_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_008578.1\|WP_011719986.1\|1278891_1279596_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl\|CDD\|187594
NC_008578.1\|WP_011720000.1\|1294990_1296280_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|181163
NC_008578.1\|WP_011719987.1\|1279595_1280363_+\|enoyl-ACP-reductase-FabI	unknown	unknown	gnl\|CDD\|236124
NC_008578.1\|WP_148204555.1\|1292420_1294097_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176654
NC_008578.1\|WP_169303194.1\|1296922_1298053_-\|ATP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|273632
NC_008578.1\|WP_011720003.1\|1298082_1299099_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|223739
NC_008578.1\|WP_041834979.1\|1299244_1299460_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_041835496.1\|1296527_1296824_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011719996.1\|1288005_1289328_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_008578.1\|WP_011720004.1\|1299463_1300138_+\|MSMEG_4193-family-putative-phosphomutase	unknown	unknown	gnl\|CDD\|163560
NC_008578.1\|WP_011719994.1\|1286219_1286432_-\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011719990.1\|1282442_1282874_+\|NfeD-family-protein	unknown	unknown	gnl\|CDD\|224501
NC_008578.1\|WP_011719988.1\|1280593_1281394_+\|transglycosylase-family-protein	unknown	unknown	gnl\|CDD\|381607
NC_008578.1\|WP_011719991.1\|1282877_1283834_+\|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl\|CDD\|223407
NC_008578.1\|WP_083760525.1\|1285086_1285986_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NC_008578.1\|WP_011719985.1\|1278236_1278623_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_011719997.1\|1289478_1290633_-\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.56217e-79
NC_008578.1\|WP_148204554.1\|1283875_1284958_-\|lytic-murein-transglycosylase	gnl\|CDD\|381602	cd13399, Slt35-like, Slt35-like lytic transglycosylase. Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).	7.13829e-29
NC_008578.1\|WP_041835493.1\|1286714_1287539_+\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	2.57418e-58
NC_008578.1\|WP_011719989.1\|1281557_1282418_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	2.3059e-93
NC_008578.1\|WP_011719986.1\|1278891_1279596_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl\|CDD\|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	9.50062e-121
NC_008578.1\|WP_011720000.1\|1294990_1296280_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|181163	PRK07906, PRK07906, hypothetical protein; Provisional.	0
NC_008578.1\|WP_011719987.1\|1279595_1280363_+\|enoyl-ACP-reductase-FabI	gnl\|CDD\|236124	PRK07889, PRK07889, enoyl-[acyl-carrier-protein] reductase FabI.	4.0086e-167
NC_008578.1\|WP_148204555.1\|1292420_1294097_+\|hypothetical-protein	gnl\|CDD\|176654	cd06142, RNaseD_exo, DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins. Ribonuclease (RNase) D is a bacterial enzyme involved in the maturation of small stable RNAs and the 3' maturation of tRNA. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. In vivo, RNase D only becomes essential upon removal of other ribonucleases. Eukaryotic RNase D homologs include yeast Rrp6p, human PM/Scl-100, and the Drosophila melanogaster egalitarian protein.	7.73591e-50
NC_008578.1\|WP_169303194.1\|1296922_1298053_-\|ATP-binding-domain-containing-protein	gnl\|CDD\|273632	TIGR01448, recD_rel, helicase, putative, RecD/TraA family. This model describes a family similar to RecD, the exodeoxyribonuclease V alpha chain of TIGR01447. Members of this family, however, are not found in a context of RecB and RecC and are longer by about 200 amino acids at the amino end. Chlamydia muridarum has both a member of this family and a RecD. [Unknown function, Enzymes of unknown specificity].	2.02189e-09
NC_008578.1\|WP_011720003.1\|1298082_1299099_-\|aldo/keto-reductase	gnl\|CDD\|223739	COG0667, Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion].	2.82927e-90
NC_008578.1\|WP_011719996.1\|1288005_1289328_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.87357e-63
NC_008578.1\|WP_011720004.1\|1299463_1300138_+\|MSMEG_4193-family-putative-phosphomutase	gnl\|CDD\|163560	TIGR03848, MSMEG_4193, probable phosphomutase, MSMEG_4193 family. A three-gene system broadly conserved among the Actinobacteria includes MSMEG_4193 and homologs, a subgroup among the larger phosphoglycerate mutase family protein (pfam00300). Another member of the trio is a probable kinase, related to phosphatidylinositol kinases; that context supports the hypothesis that this protein acts as a phosphomutase.	9.73953e-114
NC_008578.1\|WP_011719990.1\|1282442_1282874_+\|NfeD-family-protein	gnl\|CDD\|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	2.50742e-20
NC_008578.1\|WP_011719988.1\|1280593_1281394_+\|transglycosylase-family-protein	gnl\|CDD\|381607	cd13925, RPF, core lysozyme-like domain of resuscitation-promoting factor proteins. Resuscitation-promoting factor (RPF) proteins, found in various (G+C)-rich Gram-positive bacteria, act to reactivate cultures from stationary phase. This protein shares elements of the structural core of lysozyme and related proteins. Furthermore, it shares a conserved active site glutamate which is required for activity, and has a polysaccharide binding cleft that corresponds to the peptidoglycan binding cleft of lysozyme. Muralytic activity of Rpf in Micrococcus luteus correlates with resuscitation, supporting a mechanism dependent on cleavage of peptidoglycan by RPF.	2.73732e-25
NC_008578.1\|WP_011719991.1\|1282877_1283834_+\|SPFH/Band-7/PHB-domain-protein	gnl\|CDD\|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	6.77477e-64
NC_008578.1\|WP_083760525.1\|1285086_1285986_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	8.26663e-30
NC_008578.1\|WP_011719985.1\|1278236_1278623_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	5.05031e-10

>NC_008578.1|WP_011719994.1|1286219_1286432_-|hypothetical-protein
MNDLDLFSRRRGGLMRGVRGAVAWFGSGFVVGMALALLFSTLVRALIIAAAIVIVLLALIRTAIGGRRPY
>NC_008578.1|WP_083760525.1|1285086_1285986_+|sulfite-exporter-TauE/SafE-family-protein
MALSAQPRRPPRGRGVHPAGLPGRNRPPPASAVRATPYARAVPALNLLNVAGVFGAGIVAGTVNTIVGSGSLLTFPVLLGVGLSPLAANVTNTVGLVPGSVSGALGYRRELRGQRRRCLRLAVSSLIGGCVGAVLLLVLPSRSFERIVPFLVLMASLLVLVQPRLGRIVARRNSARGHDPQRTDPILDTTNGLTAVYGGYFGAAQGVILMALLGIFVPEDLQRLNAVKNVLAALVNGIAALLFAFFAPVAWWFALVEALGAVVGGQLGAVVGRRIPPRLLRAVIVIVGLVVAAKLFASW
>NC_008578.1|WP_148204554.1|1283875_1284958_-|lytic-murein-transglycosylase
MPIGGELGHRARRWLATGACVLALSPLLVPTAADAESAAQAQREAAAIAAQVQALQPQVTAALAAYEAALDGVARSVSATVADRRVYEALQAQADQAAATYAAGIAALYEAGGPLGIYAALLTTGVPPDLRHLPYVSGVLSRQAAWAETTRQFASAAKQRLDADEASIDTELDNAATIQQRYLVLQGLLDRAQAILDAATARARALAAWESAAAALAAVRVAADQAGVDAAANAVAEPIPDAYRAWYQAAAKTCPGLPWQVLAAIGQVESHHGQGTMVSAAGALGPMQFLPATFARYATDGNGDGKADIWNPADAIFTAARYLCANGAGQGEAGLQAALWNYNHAEWYVQLVLAIAAKIR
>NC_008578.1|WP_011719991.1|1282877_1283834_+|SPFH/Band-7/PHB-domain-protein
MPAAVIALIVIAIFVLIVLGRSVRIVPQARAGIVERLGRYHRTLAPGLNVVVPFIDRIRPLIDMREQVVSFPPQPVITQDNLVVGIDTVLYFQVTDAKAATYEIANYIQAIEQLTVTTLRNVIGGMDLEKTLTSREEINAQLRGVLDEATGKWGIRVNRVELKSIDPPLSIKDSMEKQMRADRDKRAAILLAEGQKQAQILTAEGEKQAAILRAEGQAQAAVTQARAEAEAQALRANGQAQAIGTVFRAIHEGKVDPDLLAYQYLQVLPQIAQGDANKVWIVPSEISKALEGVGNLFGRAAAPGNPDGAAAQRTTSPE
>NC_008578.1|WP_011719990.1|1282442_1282874_+|NfeD-family-protein
MPMWLIWTIVAVACAGAEALTLTLILGFIAAAAALTLVAAVLGAPIVAQLLVFVGSAAALLGVVRPIARAHLYTPPALRTGVDALVGQRGLVVERVDAHHGQIKIGGELWSARPYVDGQCYEPGTTVEVVKIQGAIALVFGTE
>NC_008578.1|WP_011719989.1|1281557_1282418_+|ABC-transporter-ATP-binding-protein
MVEVWHAVRGSAHDPALFGVRVAESAGDVVVRLRSASVVRGGATLLADIDWEVRGGEHWVVLGPNGAGKTTLLKLLSTQWHPTTGEVEVLGERMGAVDVFELRPRIGFSSAALADRLPAGERVRDVVLTASYGTIGRWREQYDEADFARAHAVLARLGVGHLRDRRYGSLSEGERKRVQLARALMSDPELLLLDEPAAGLDLGGREDLLAQLAHLLQSPTAPATVLVTHHVEEIPRGITHGLLLRAGRIVARGPLTEVLTAANLSVTFARDLVVEAHDGRFFARSI
>NC_008578.1|WP_011719988.1|1280593_1281394_+|transglycosylase-family-protein
MGAHRYRGPRHARPKGPRHAKPAPPSVAGRTVAATGFAVAMLTGELASAASASAVGSDVWAALRMCESSGNYHINTGNGYYGAYQFDLRTWRGLGYSGLPSDAPPAVQDEAAQRLYAQRGWQPWPACSRKLGLVDDRASRSANRPPLDPPQGVDPPQGTDTATAEVVRAAAQDTGPAVRSGPAGPAPVPRLPWNGHYLTVRDVYQVRDDVRLFQQAMVAHGYHIAVDGRYGPQSAAATTAFERAHHLHVEDPGVVGPQVWGALFGT
>NC_008578.1|WP_011719987.1|1279595_1280363_+|enoyl-ACP-reductase-FabI
MGILDGKQLLVTGVLTDASIAFHVARLAQLEGAEVLLSSYGRAFRLTERIAGRLPKPAPVIELDVTNAEDLAALPDRVRAHLTRLDGVVHAIAYAPEGALGGKFLQTPWEDVATALHVSAYSLKALATAATPLMGEGSSLVGLDFDASVAWPLYDWMGVAKAALESCARYLARDLGPRGIRVNLVSAGPVRTVAAKGIPGFESLAAIWTERAPLSWDLSDGEAPARAVIALLSDWFPKTTGEIVHVDGGVHAVGA
>NC_008578.1|WP_011719986.1|1278891_1279596_+|3-oxoacyl-[acyl-carrier-protein]-reductase
MARCVLVTGGSRGIGLAIAQAFAADGDHVAVTYRSSEPPAGLFAVRADVTNSDEVEKAFDAVEAEFGPVQVLVANAGITRDTLLLRMTEDDWRTVLETNLTGAYRVAKRAVRSMLRARSGRLLFISSVVGLLGSAGQANYAATKAGLIGFARSLAREFGSRGITANVVAPGFVDTEMTRVLGDERRAEILKQVPLGRYATPEEVAGVVRFLASDAASYITGAVIPVDGGLGMGH
>NC_008578.1|WP_011719985.1|1278236_1278623_-|STAS-domain-containing-protein
MTTMTADSLGSVSTTVLADGIVVRLGGSLDAASLPELRAALLTERPEGRDDVLVDASRVTEVHERALAILVAAVSWAEQTGGRLQFAAMSPALAETARYFAVHDLLPLLPGPGGRAERAALTVAGDGC
>NC_008578.1|WP_041835493.1|1286714_1287539_+|RNA-methyltransferase
MAEVVPIYDPQDPRLADYRALTDVELRKRVEPAHGIFIAESALVIQRALAAGYRMISAFVSDRWLDELADQLSSVEAPVYVGAPEVLQSVTGFHVHRGALAAFARRPLSSVEEILRTSRRIVVLEDVNNHTNLGAVFRCAAALGMDGVLLSPRCADPLYRRSVRVSMGAVFAIPYARFDTWPDELTGVSAAQFRLLALTPDPAATDIRTLRVAAGERIALMLGAEGPGLSKQALDRAELRVRIPMHAGVDSLNVAAAAAIACFVVGEPAPPRLD
>NC_008578.1|WP_011719996.1|1288005_1289328_+|GGDEF-domain-containing-protein
MTVLPRAWALATMPRPARHFVLAVDALYLMALIAGGMRTSFRTTDLVTAGVLTGLAIVSIETSLRFVWHRPHGGGSTNDLLAVWTLPVALLLPPLYSALVVVPVLLFTQVRVVRRAPVKLIFSIASTGIAGFVAASVHEAYFGSGTVWTPETLVGSPRALAATASCVLVRYVVNLLLVGQVVALTKPKTSPFALLKNRENLGISAAEACTGVLVALACATALYAVPLAIPPVLVFQRTLLIAELRHAARTDPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRPRDFVGRFGGEEFVILLAGSDLEQAAVAAERVRQHIAHLTVDTPLHGDPVSVTVSVGVAAFRENGHSVLELLDAADAALYEAKRAGRNCVRVATGVRQQVLDLTGDTPRLIDLRTERQPIVD
>NC_008578.1|WP_011719997.1|1289478_1290633_-|MFS-transporter
MDPVLLAPPRLSAQRARIVIATIFAVHGVVFATFATRIPWLQDRLGLSAGSLGAALLFGAIGGLLGMPFASRLLHRFGGRRTTRVLMAAWCIAGALPVLAPNLAALIPLLLLYGMTSGMADVAMNAQAIPVERDLGKSIMSGLHGMWSVGGIVGSAVGVAAAHAGLDARIHLAIVDAALLVVALGATSKLPVNLPDAAEPPPKPFVVPSRGVLLIGLVAFCAIFAEAASSDWCAVYLTRITGADPGIAAASYTAFACTMAAARFGGDFAVRRLGLRSTVRIGGVVGTLGALLVVAAFAIAPTIVGFALIGLGIAVTFPLAVAAAGHADPIPARGISGVATISYGAGIAAPGIIGGIADATSLQVSFGVVAAVIAFIAVGARYLR
>NC_008578.1|WP_148204555.1|1292420_1294097_+|hypothetical-protein
MTTSPSNEMSTLVKRLTLGRVRRFFTPPEEQALVDGARAYLTGDEELALEHLGKAVKLPDAAYLAGLLALNNAQFDNAATWLTSALERHKQLGRYLAKYRVNVTVLIPIGKLVAVPITPNQRGVLLSLAVLYRQREQWDEAISRAEKLLDLDPADMSARLCLADILLEARPSTEHNFRRVVSLIPDLDEVTALHGALLLCRARALHKLGLLEAAHDALNAMIRRKVNRPTELQRALRYERACLYDKMGQHRRARVEWEKLYAEDPDYADVADRLHATNHPASTSRHANGRKAEPPPTPSSQDSPSDISNLDTSGRRHRDEVTHGTTIRNNDQSFDLPSHGGQVDGSTTASRVRRTDDDHDGYRIEVMSQDVTPDFLRYIYSTGKAGWDIETTGLNWYADRICTVQLACGNRVAVVQLPEGHTPQRLSQILGDQNILKIFHNARFDLRFMVYHWSVIPQNVACTLELVRLLNPRERAGHTLREVLERYLAVQIIKDQTCSDWTTAQLTQEQIRYATNDVRYLPVLFDLLMNMARERRLEEAAMRRFRQMLKDVFTFRYP
>NC_008578.1|WP_011720000.1|1294990_1296280_+|M20/M25/M40-family-metallo-hydrolase
MTTTAEAEVVDLCAELIRIDTSNPIKPERPAAEYVAAKLAEVGLTPTILESEPGRASVVARMPGADPGRPALLIHGHLDVVPADPADWQVHPFSGEIKDGYLWGRGAIDMKDMDAMVLAVVRDRMRTRRPPARDVVLAFVADEEAGGGKGARFLVDNHRDLFDGCTESISEVGGFSIDLNGTRLYPVQTAQRGMTWLKLTATGRAGHGSLVNDANPVTALAETVARIGTYDWPVRVTPCTREFLTALGAALGEPIDPDNLSALAPRLGSVTALVASTLRNTANPTMLEAGYKVNVVPQTANAYIDGRYLPGYREEFLTTIEKLLHPRVRYEIVHDDVALENPWSGPLVDAMVTALTAEDPDGKPIPYCLFGGTDDKSFSRLGITGYGFSPLRLAPDLDFAGMFHAVDERVNIAALQFGVRVLDRFLDLC
>NC_008578.1|WP_041835496.1|1296527_1296824_+|hypothetical-protein
MPVSPADVRSAAEALKAAIDTHLAAVENRSGENDPRVQQAYDALAAAAETYDDLLFSAYEEVTPFGPSDVDEDDDEDDVDEDDDAGFGDDLEWEPDSR
>NC_008578.1|WP_169303194.1|1296922_1298053_-|ATP-binding-domain-containing-protein
MPAGGPAMDAVGGGGLPGPGSPRVGGVSRDEENAAAAVLLGLLETAARDGHTVVPLTVVRAALAGRGVECDDALEGARADVAVFAGTRLGLRRLLDAEDRIARAVATRMAGGRIALVAGPAGERRDDLVTQVGGDGAAVADDAQSLDVEAFAAFFESCGTDEMVVLAGDPDELGSPGPGDVFASLLAVDGIPRYDVPDDGAGALAQLLAGIRRGELPRIEDPDRQVVVVPVANAAEAVHRVSQLLATSIPRAFGIPPAEIQVLCPLRRGPGGVLALRDAVATVGAPAPRTIHEAVGYRWPAVVVVFSPECAGVLTRQLVYTALSRAERHVSIVHGVGTALAGAVRSIATRPRRTTLRERLTQLTADQRLTQLTADG
>NC_008578.1|WP_011720003.1|1298082_1299099_-|aldo/keto-reductase
MEIRYLGTSGLAVGWLGLGTALWGRDTDEHEAAEQLRDFVESGGQLIDTGDAYGGGAAEAVVGALLAGRFARSDVVLAVKTGGGAPDAAAGDADLSRRGLLAALDGSLRRLGVDHIDLWQIDGVDPVTPLEETLSALDIAVSSGRVRYVGLANFCGWRTAKAAAWQAAWPGRARLISNQVEYSLLQRGVEREVVPAMRDAGMSILAWSPLGRGVLTGKYRTGIPADSRAASDHLAAFVQPYLGPESTRIVNAVCTAAQGLGVSPLAVALAWVRDRPGVGGVLVGARTAAQLRGILAECDLTLPAEISAALDEVSAVPSGYPERTAAERATAGPSPAFS
>NC_008578.1|WP_041834979.1|1299244_1299460_+|hypothetical-protein
MARFSSARPLQPWQFWAGIIILVVCGALALLALAGTVGAHSSCPNPGQDSRPANANCFPPYQHQEQTGVVG
>NC_008578.1|WP_011720004.1|1299463_1300138_+|MSMEG_4193-family-putative-phosphomutase
MTTVIFLRHGLTESTGRLLTGRMPGVHLDSRGLAQAADLAKRLAGIRLSAIVSSPLERCRETVQPIADQTGLPIEIEPGVIECGYGDWTGRDLRHLTKDPLWRILQTHPSSVVFPGAEGESLRAVQYRAVDAVRAWNARLGAKAAWLCCTHADVIRLVLADALGMHLDEFQRLIIDPCSVSIVRYTTTRPFVLRVNDTGGDLASLIEPAARRRSRGSTRPRATP

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Crispr_ID: NC_008578_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_7

1290678-1290813

Orphan

Consensus_repeat	Method
TCGGCGAGGCTGCGGCGGGAAGAACATGGCGGCACCCGCCCGGCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_7

>merge|NC_008578|7|1290678-1290813|CRISPRCasFinder
TCGGCGAGGCTGCGGCGGGAAGAACATGGCGGCACCCGCCCGGCCGCGGAAGCTAGGCGCCACCGGCGGCGGAGGCTGGCAAGGCAAACTCGGCGGGGCTGCGGCGGGAAGAACATGGCGGCACCCGCCCGGCCGC

>NC_008578|7|7|1290678-1290813|CRISPRCasFinder
TCGGCGAGGCTGCGGCGGGAAGAACATGGCGGCACCCGCCCGGCCGC	GGAAGCTAGGCGCCACCGGCGGCGGAGGCTGGCAAGGCAAAC
TCGGCGGGGCTGCGGCGGGAAGAACATGGCGGCACCCGCCCGGCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_011719997.1\|1289478_1290633_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NC_008578.1\|WP_148204554.1\|1283875_1284958_-\|lytic-murein-transglycosylase	unknown	unknown	gnl\|CDD\|381602
NC_008578.1\|WP_041835493.1\|1286714_1287539_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NC_008578.1\|WP_011719989.1\|1281557_1282418_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_008578.1\|WP_041834979.1\|1299244_1299460_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720000.1\|1294990_1296280_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|181163
NC_008578.1\|WP_011720005.1\|1300147_1300720_+\|DUF3090-domain-containing-protein	unknown	unknown	gnl\|CDD\|213872
NC_008578.1\|WP_148204555.1\|1292420_1294097_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176654
NC_008578.1\|WP_011720007.1\|1301463_1302675_+\|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase	unknown	unknown	gnl\|CDD\|183518
NC_008578.1\|WP_169303194.1\|1296922_1298053_-\|ATP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|273632
NC_008578.1\|WP_011720003.1\|1298082_1299099_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|223739
NC_008578.1\|WP_011719996.1\|1288005_1289328_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_008578.1\|WP_011720004.1\|1299463_1300138_+\|MSMEG_4193-family-putative-phosphomutase	unknown	unknown	gnl\|CDD\|163560
NC_008578.1\|WP_011719994.1\|1286219_1286432_-\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011719990.1\|1282442_1282874_+\|NfeD-family-protein	unknown	unknown	gnl\|CDD\|224501
NC_008578.1\|WP_011719988.1\|1280593_1281394_+\|transglycosylase-family-protein	unknown	unknown	gnl\|CDD\|381607
NC_008578.1\|WP_011719991.1\|1282877_1283834_+\|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl\|CDD\|223407
NC_008578.1\|WP_041835496.1\|1296527_1296824_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720006.1\|1300719_1301439_+\|SCO1664-family-protein	unknown	unknown	gnl\|CDD\|274813
NC_008578.1\|WP_083760525.1\|1285086_1285986_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_011719997.1\|1289478_1290633_-\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.56217e-79
NC_008578.1\|WP_148204554.1\|1283875_1284958_-\|lytic-murein-transglycosylase	gnl\|CDD\|381602	cd13399, Slt35-like, Slt35-like lytic transglycosylase. Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).	7.13829e-29
NC_008578.1\|WP_041835493.1\|1286714_1287539_+\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	2.57418e-58
NC_008578.1\|WP_011719989.1\|1281557_1282418_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	2.3059e-93
NC_008578.1\|WP_011720005.1\|1300147_1300720_+\|DUF3090-domain-containing-protein	gnl\|CDD\|213872	TIGR03847, TIGR03847, conserved hypothetical protein. The conserved hypothetical protein described here occurs as part of the trio of uncharacterized proteins common in the Actinobacteria.	7.36399e-88
NC_008578.1\|WP_011720000.1\|1294990_1296280_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|181163	PRK07906, PRK07906, hypothetical protein; Provisional.	0
NC_008578.1\|WP_011720007.1\|1301463_1302675_+\|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase	gnl\|CDD\|183518	PRK12418, PRK12418, cysteinyl-tRNA synthetase; Provisional.	0
NC_008578.1\|WP_148204555.1\|1292420_1294097_+\|hypothetical-protein	gnl\|CDD\|176654	cd06142, RNaseD_exo, DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins. Ribonuclease (RNase) D is a bacterial enzyme involved in the maturation of small stable RNAs and the 3' maturation of tRNA. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. In vivo, RNase D only becomes essential upon removal of other ribonucleases. Eukaryotic RNase D homologs include yeast Rrp6p, human PM/Scl-100, and the Drosophila melanogaster egalitarian protein.	7.73591e-50
NC_008578.1\|WP_169303194.1\|1296922_1298053_-\|ATP-binding-domain-containing-protein	gnl\|CDD\|273632	TIGR01448, recD_rel, helicase, putative, RecD/TraA family. This model describes a family similar to RecD, the exodeoxyribonuclease V alpha chain of TIGR01447. Members of this family, however, are not found in a context of RecB and RecC and are longer by about 200 amino acids at the amino end. Chlamydia muridarum has both a member of this family and a RecD. [Unknown function, Enzymes of unknown specificity].	2.02189e-09
NC_008578.1\|WP_011720003.1\|1298082_1299099_-\|aldo/keto-reductase	gnl\|CDD\|223739	COG0667, Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion].	2.82927e-90
NC_008578.1\|WP_011719996.1\|1288005_1289328_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.87357e-63
NC_008578.1\|WP_011720004.1\|1299463_1300138_+\|MSMEG_4193-family-putative-phosphomutase	gnl\|CDD\|163560	TIGR03848, MSMEG_4193, probable phosphomutase, MSMEG_4193 family. A three-gene system broadly conserved among the Actinobacteria includes MSMEG_4193 and homologs, a subgroup among the larger phosphoglycerate mutase family protein (pfam00300). Another member of the trio is a probable kinase, related to phosphatidylinositol kinases; that context supports the hypothesis that this protein acts as a phosphomutase.	9.73953e-114
NC_008578.1\|WP_011719990.1\|1282442_1282874_+\|NfeD-family-protein	gnl\|CDD\|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	2.50742e-20
NC_008578.1\|WP_011719988.1\|1280593_1281394_+\|transglycosylase-family-protein	gnl\|CDD\|381607	cd13925, RPF, core lysozyme-like domain of resuscitation-promoting factor proteins. Resuscitation-promoting factor (RPF) proteins, found in various (G+C)-rich Gram-positive bacteria, act to reactivate cultures from stationary phase. This protein shares elements of the structural core of lysozyme and related proteins. Furthermore, it shares a conserved active site glutamate which is required for activity, and has a polysaccharide binding cleft that corresponds to the peptidoglycan binding cleft of lysozyme. Muralytic activity of Rpf in Micrococcus luteus correlates with resuscitation, supporting a mechanism dependent on cleavage of peptidoglycan by RPF.	2.73732e-25
NC_008578.1\|WP_011719991.1\|1282877_1283834_+\|SPFH/Band-7/PHB-domain-protein	gnl\|CDD\|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	6.77477e-64
NC_008578.1\|WP_011720006.1\|1300719_1301439_+\|SCO1664-family-protein	gnl\|CDD\|274813	TIGR03843, Phosphatidylinositol_3-_and_4-kinase, conserved hypothetical protein. This model represents a protein family largely restricted to the Actinobacteria (high-GC Gram-positives), although it is also found in the Chloroflexi. Distant similarity to the phosphatidylinositol 3- and 4-kinase is suggested by the matching of some members to pfam00454.	3.96528e-137
NC_008578.1\|WP_083760525.1\|1285086_1285986_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	8.26663e-30

>NC_008578.1|WP_011719997.1|1289478_1290633_-|MFS-transporter
MDPVLLAPPRLSAQRARIVIATIFAVHGVVFATFATRIPWLQDRLGLSAGSLGAALLFGAIGGLLGMPFASRLLHRFGGRRTTRVLMAAWCIAGALPVLAPNLAALIPLLLLYGMTSGMADVAMNAQAIPVERDLGKSIMSGLHGMWSVGGIVGSAVGVAAAHAGLDARIHLAIVDAALLVVALGATSKLPVNLPDAAEPPPKPFVVPSRGVLLIGLVAFCAIFAEAASSDWCAVYLTRITGADPGIAAASYTAFACTMAAARFGGDFAVRRLGLRSTVRIGGVVGTLGALLVVAAFAIAPTIVGFALIGLGIAVTFPLAVAAAGHADPIPARGISGVATISYGAGIAAPGIIGGIADATSLQVSFGVVAAVIAFIAVGARYLR
>NC_008578.1|WP_011719996.1|1288005_1289328_+|GGDEF-domain-containing-protein
MTVLPRAWALATMPRPARHFVLAVDALYLMALIAGGMRTSFRTTDLVTAGVLTGLAIVSIETSLRFVWHRPHGGGSTNDLLAVWTLPVALLLPPLYSALVVVPVLLFTQVRVVRRAPVKLIFSIASTGIAGFVAASVHEAYFGSGTVWTPETLVGSPRALAATASCVLVRYVVNLLLVGQVVALTKPKTSPFALLKNRENLGISAAEACTGVLVALACATALYAVPLAIPPVLVFQRTLLIAELRHAARTDPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRPRDFVGRFGGEEFVILLAGSDLEQAAVAAERVRQHIAHLTVDTPLHGDPVSVTVSVGVAAFRENGHSVLELLDAADAALYEAKRAGRNCVRVATGVRQQVLDLTGDTPRLIDLRTERQPIVD
>NC_008578.1|WP_041835493.1|1286714_1287539_+|RNA-methyltransferase
MAEVVPIYDPQDPRLADYRALTDVELRKRVEPAHGIFIAESALVIQRALAAGYRMISAFVSDRWLDELADQLSSVEAPVYVGAPEVLQSVTGFHVHRGALAAFARRPLSSVEEILRTSRRIVVLEDVNNHTNLGAVFRCAAALGMDGVLLSPRCADPLYRRSVRVSMGAVFAIPYARFDTWPDELTGVSAAQFRLLALTPDPAATDIRTLRVAAGERIALMLGAEGPGLSKQALDRAELRVRIPMHAGVDSLNVAAAAAIACFVVGEPAPPRLD
>NC_008578.1|WP_011719994.1|1286219_1286432_-|hypothetical-protein
MNDLDLFSRRRGGLMRGVRGAVAWFGSGFVVGMALALLFSTLVRALIIAAAIVIVLLALIRTAIGGRRPY
>NC_008578.1|WP_083760525.1|1285086_1285986_+|sulfite-exporter-TauE/SafE-family-protein
MALSAQPRRPPRGRGVHPAGLPGRNRPPPASAVRATPYARAVPALNLLNVAGVFGAGIVAGTVNTIVGSGSLLTFPVLLGVGLSPLAANVTNTVGLVPGSVSGALGYRRELRGQRRRCLRLAVSSLIGGCVGAVLLLVLPSRSFERIVPFLVLMASLLVLVQPRLGRIVARRNSARGHDPQRTDPILDTTNGLTAVYGGYFGAAQGVILMALLGIFVPEDLQRLNAVKNVLAALVNGIAALLFAFFAPVAWWFALVEALGAVVGGQLGAVVGRRIPPRLLRAVIVIVGLVVAAKLFASW
>NC_008578.1|WP_148204554.1|1283875_1284958_-|lytic-murein-transglycosylase
MPIGGELGHRARRWLATGACVLALSPLLVPTAADAESAAQAQREAAAIAAQVQALQPQVTAALAAYEAALDGVARSVSATVADRRVYEALQAQADQAAATYAAGIAALYEAGGPLGIYAALLTTGVPPDLRHLPYVSGVLSRQAAWAETTRQFASAAKQRLDADEASIDTELDNAATIQQRYLVLQGLLDRAQAILDAATARARALAAWESAAAALAAVRVAADQAGVDAAANAVAEPIPDAYRAWYQAAAKTCPGLPWQVLAAIGQVESHHGQGTMVSAAGALGPMQFLPATFARYATDGNGDGKADIWNPADAIFTAARYLCANGAGQGEAGLQAALWNYNHAEWYVQLVLAIAAKIR
>NC_008578.1|WP_011719991.1|1282877_1283834_+|SPFH/Band-7/PHB-domain-protein
MPAAVIALIVIAIFVLIVLGRSVRIVPQARAGIVERLGRYHRTLAPGLNVVVPFIDRIRPLIDMREQVVSFPPQPVITQDNLVVGIDTVLYFQVTDAKAATYEIANYIQAIEQLTVTTLRNVIGGMDLEKTLTSREEINAQLRGVLDEATGKWGIRVNRVELKSIDPPLSIKDSMEKQMRADRDKRAAILLAEGQKQAQILTAEGEKQAAILRAEGQAQAAVTQARAEAEAQALRANGQAQAIGTVFRAIHEGKVDPDLLAYQYLQVLPQIAQGDANKVWIVPSEISKALEGVGNLFGRAAAPGNPDGAAAQRTTSPE
>NC_008578.1|WP_011719990.1|1282442_1282874_+|NfeD-family-protein
MPMWLIWTIVAVACAGAEALTLTLILGFIAAAAALTLVAAVLGAPIVAQLLVFVGSAAALLGVVRPIARAHLYTPPALRTGVDALVGQRGLVVERVDAHHGQIKIGGELWSARPYVDGQCYEPGTTVEVVKIQGAIALVFGTE
>NC_008578.1|WP_011719989.1|1281557_1282418_+|ABC-transporter-ATP-binding-protein
MVEVWHAVRGSAHDPALFGVRVAESAGDVVVRLRSASVVRGGATLLADIDWEVRGGEHWVVLGPNGAGKTTLLKLLSTQWHPTTGEVEVLGERMGAVDVFELRPRIGFSSAALADRLPAGERVRDVVLTASYGTIGRWREQYDEADFARAHAVLARLGVGHLRDRRYGSLSEGERKRVQLARALMSDPELLLLDEPAAGLDLGGREDLLAQLAHLLQSPTAPATVLVTHHVEEIPRGITHGLLLRAGRIVARGPLTEVLTAANLSVTFARDLVVEAHDGRFFARSI
>NC_008578.1|WP_011719988.1|1280593_1281394_+|transglycosylase-family-protein
MGAHRYRGPRHARPKGPRHAKPAPPSVAGRTVAATGFAVAMLTGELASAASASAVGSDVWAALRMCESSGNYHINTGNGYYGAYQFDLRTWRGLGYSGLPSDAPPAVQDEAAQRLYAQRGWQPWPACSRKLGLVDDRASRSANRPPLDPPQGVDPPQGTDTATAEVVRAAAQDTGPAVRSGPAGPAPVPRLPWNGHYLTVRDVYQVRDDVRLFQQAMVAHGYHIAVDGRYGPQSAAATTAFERAHHLHVEDPGVVGPQVWGALFGT
>NC_008578.1|WP_148204555.1|1292420_1294097_+|hypothetical-protein
MTTSPSNEMSTLVKRLTLGRVRRFFTPPEEQALVDGARAYLTGDEELALEHLGKAVKLPDAAYLAGLLALNNAQFDNAATWLTSALERHKQLGRYLAKYRVNVTVLIPIGKLVAVPITPNQRGVLLSLAVLYRQREQWDEAISRAEKLLDLDPADMSARLCLADILLEARPSTEHNFRRVVSLIPDLDEVTALHGALLLCRARALHKLGLLEAAHDALNAMIRRKVNRPTELQRALRYERACLYDKMGQHRRARVEWEKLYAEDPDYADVADRLHATNHPASTSRHANGRKAEPPPTPSSQDSPSDISNLDTSGRRHRDEVTHGTTIRNNDQSFDLPSHGGQVDGSTTASRVRRTDDDHDGYRIEVMSQDVTPDFLRYIYSTGKAGWDIETTGLNWYADRICTVQLACGNRVAVVQLPEGHTPQRLSQILGDQNILKIFHNARFDLRFMVYHWSVIPQNVACTLELVRLLNPRERAGHTLREVLERYLAVQIIKDQTCSDWTTAQLTQEQIRYATNDVRYLPVLFDLLMNMARERRLEEAAMRRFRQMLKDVFTFRYP
>NC_008578.1|WP_011720000.1|1294990_1296280_+|M20/M25/M40-family-metallo-hydrolase
MTTTAEAEVVDLCAELIRIDTSNPIKPERPAAEYVAAKLAEVGLTPTILESEPGRASVVARMPGADPGRPALLIHGHLDVVPADPADWQVHPFSGEIKDGYLWGRGAIDMKDMDAMVLAVVRDRMRTRRPPARDVVLAFVADEEAGGGKGARFLVDNHRDLFDGCTESISEVGGFSIDLNGTRLYPVQTAQRGMTWLKLTATGRAGHGSLVNDANPVTALAETVARIGTYDWPVRVTPCTREFLTALGAALGEPIDPDNLSALAPRLGSVTALVASTLRNTANPTMLEAGYKVNVVPQTANAYIDGRYLPGYREEFLTTIEKLLHPRVRYEIVHDDVALENPWSGPLVDAMVTALTAEDPDGKPIPYCLFGGTDDKSFSRLGITGYGFSPLRLAPDLDFAGMFHAVDERVNIAALQFGVRVLDRFLDLC
>NC_008578.1|WP_041835496.1|1296527_1296824_+|hypothetical-protein
MPVSPADVRSAAEALKAAIDTHLAAVENRSGENDPRVQQAYDALAAAAETYDDLLFSAYEEVTPFGPSDVDEDDDEDDVDEDDDAGFGDDLEWEPDSR
>NC_008578.1|WP_169303194.1|1296922_1298053_-|ATP-binding-domain-containing-protein
MPAGGPAMDAVGGGGLPGPGSPRVGGVSRDEENAAAAVLLGLLETAARDGHTVVPLTVVRAALAGRGVECDDALEGARADVAVFAGTRLGLRRLLDAEDRIARAVATRMAGGRIALVAGPAGERRDDLVTQVGGDGAAVADDAQSLDVEAFAAFFESCGTDEMVVLAGDPDELGSPGPGDVFASLLAVDGIPRYDVPDDGAGALAQLLAGIRRGELPRIEDPDRQVVVVPVANAAEAVHRVSQLLATSIPRAFGIPPAEIQVLCPLRRGPGGVLALRDAVATVGAPAPRTIHEAVGYRWPAVVVVFSPECAGVLTRQLVYTALSRAERHVSIVHGVGTALAGAVRSIATRPRRTTLRERLTQLTADQRLTQLTADG
>NC_008578.1|WP_011720003.1|1298082_1299099_-|aldo/keto-reductase
MEIRYLGTSGLAVGWLGLGTALWGRDTDEHEAAEQLRDFVESGGQLIDTGDAYGGGAAEAVVGALLAGRFARSDVVLAVKTGGGAPDAAAGDADLSRRGLLAALDGSLRRLGVDHIDLWQIDGVDPVTPLEETLSALDIAVSSGRVRYVGLANFCGWRTAKAAAWQAAWPGRARLISNQVEYSLLQRGVEREVVPAMRDAGMSILAWSPLGRGVLTGKYRTGIPADSRAASDHLAAFVQPYLGPESTRIVNAVCTAAQGLGVSPLAVALAWVRDRPGVGGVLVGARTAAQLRGILAECDLTLPAEISAALDEVSAVPSGYPERTAAERATAGPSPAFS
>NC_008578.1|WP_041834979.1|1299244_1299460_+|hypothetical-protein
MARFSSARPLQPWQFWAGIIILVVCGALALLALAGTVGAHSSCPNPGQDSRPANANCFPPYQHQEQTGVVG
>NC_008578.1|WP_011720004.1|1299463_1300138_+|MSMEG_4193-family-putative-phosphomutase
MTTVIFLRHGLTESTGRLLTGRMPGVHLDSRGLAQAADLAKRLAGIRLSAIVSSPLERCRETVQPIADQTGLPIEIEPGVIECGYGDWTGRDLRHLTKDPLWRILQTHPSSVVFPGAEGESLRAVQYRAVDAVRAWNARLGAKAAWLCCTHADVIRLVLADALGMHLDEFQRLIIDPCSVSIVRYTTTRPFVLRVNDTGGDLASLIEPAARRRSRGSTRPRATP
>NC_008578.1|WP_011720005.1|1300147_1300720_+|DUF3090-domain-containing-protein
MPREVYVYDTPDRVVIGTVGQPGHRTFFLQVRENDRLTSVVLEKAQVAVLAERLDAMLDEVVRVSGGVASVPAVAPADLDDDAPLDEPIVEAFRVGALGLGWDPETEQVVIEAQAIDPDAEEEILVEDDDADGPPLLRIRMSGAVARAFAKRALAVVAAGRPTCQFCGQPIDPTGHICARANGHKPHGSS
>NC_008578.1|WP_011720006.1|1300719_1301439_+|SCO1664-family-protein
MTNYDDAEVRHVLAEGELRVEGRLVDASNTTLYACARLGGCEIPCVYKPIAGERPLWDFPDGTLAYREVAAYLVSQATGWGIVPPTVLRDGPFGPGACQVWVEVDPDVDLLELLRSDHPGLQRIAVFDAVVNNADRKGGHLLPTKAGHIFGVDHGVCFAVEDKLRTVLWQWRSQPLPADAVETLRALRDKLAGDLGAELAALLSRQEIAATRRRVNRLLATRRFPEPPEHWPAIPWPPL
>NC_008578.1|WP_011720007.1|1301463_1302675_+|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase
MHAWPAPKIPSLPGRNRLPSLFDTASRRLVTVGSQQGASMYVCGITPYDATHLGHAATYVAFDLLVRTWHDAGVTVRYAQNVTDVDDPLLERARQVDQPWEAIAARETAKFRADMAALRVVPPDRYVGVVESLPQIIGLIEVLRSRGLTYELDGDQYFATHAIPDFGAVSHLGRDDMIALFAARGGDPDRAGKKDPLDALLWRGKRPEEPSWPAPFGRGRPGWHVECAAIALTHLPLPLDVQGGGADLVFPHHDMTAAQAEAATGRRFARAYVHTGLVAYQGEKMSKSLGNLVFVSDLCAAGADPMAVRLALLDHHYRTEWEWTPRLLDEATDRLAEWRAAVRRPRGAPGDGLLAAVRDRLADDLDAPGAIALIDEWTTQDGDDPDAPTLVAAMADALLGVHL

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Crispr_ID: NC_008578_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_8

1547941-1548204

Orphan

Consensus_repeat	Method
GGCGCCCCACATCCGCGCATCCCA	CRISPRCasFinder

5 spacers

The CRISPR arrays of NC_008578_8

>merge|NC_008578|8|1547941-1548204|CRISPRCasFinder
AGCGTCCCATATCTGGGCGCCCCACATCCGCGCATCCCAGACATCAGCGCCCCACATCCGCGCACCCCACATACGGGCGCCCCACATCCGCGCATCCCACGAGCCGGCGCCCCACATCCGCGCACCCCACATCCGGGCCTCCCAGGAATCGGCGCCCCACATCCGCGCGTCCCAGGAATCGGCACCCCACATACGGGCACCCCACATCCGCGCATCCCACGAGTCGACGCCCCACATCCGCGCACCCCACATCCGGGCGCCCCA

>NC_008578|8|8|1547941-1548204|CRISPRCasFinder
AGCGTCCCATATCTGGGCGCCCCA	CATCCGCGCATCCCAGACATC
AGCGCCCCACATCCGCGCACCCCA	CATACGGGCGCCCCACATCCGCGCATCCCACGAGCC
GGCGCCCCACATCCGCGCACCCCA	CATCCGGGCCTCCCAGGAATC
GGCGCCCCACATCCGCGCGTCCCA	GGAATCGGCACCCCACATACG
GGCACCCCACATCCGCGCATCCCA	CGAGTCGACGCCCCACATCCG
CGCACCCCACATCCGGGCGCCCCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_011720218.1\|1541446_1542298_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|307170
NC_008578.1\|WP_011720227.1\|1552469_1553345_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720233.1\|1562488_1563163_+\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643
NC_008578.1\|WP_011720223.1\|1546432_1547920_-\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720234.1\|1563253_1563955_+\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643
NC_008578.1\|WP_083760636.1\|1560191_1562354_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NC_008578.1\|WP_011720217.1\|1540285_1541392_-\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NC_008578.1\|WP_148204677.1\|1551000_1552212_+\|HRDC-domain-containing-protein	unknown	unknown	gnl\|CDD\|223426
NC_008578.1\|WP_083760635.1\|1550058_1550796_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_008578.1\|WP_011720216.1\|1538897_1540289_-\|protoporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|237009
NC_008578.1\|WP_011720214.1\|1537787_1538189_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|376583
NC_008578.1\|WP_011720220.1\|1543621_1544503_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213236
NC_008578.1\|WP_041834997.1\|1558570_1559005_-\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_049751621.1\|1538194_1538842_-\|chlorite-dismutase-family-protein	unknown	unknown	gnl\|CDD\|377705
NC_008578.1\|WP_011720222.1\|1545332_1546436_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_008578.1\|WP_011720219.1\|1542407_1543625_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224582
NC_008578.1\|WP_011720231.1\|1559001_1560195_-\|class-I-SAM-dependent-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|225174
NC_008578.1\|WP_011720229.1\|1555627_1558408_-\|aconitate-hydratase	unknown	unknown	gnl\|CDD\|236445
NC_008578.1\|WP_011720221.1\|1544672_1545290_+\|DUF3000-domain-containing-protein	unknown	unknown	gnl\|CDD\|378665
NC_008578.1\|WP_041835564.1\|1553508_1555404_-\|1-deoxy-D-xylulose-5-phosphate-synthase	unknown	unknown	gnl\|CDD\|235470

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_011720218.1\|1541446_1542298_-\|DMT-family-transporter	gnl\|CDD\|307170	pfam00892, EamA, EamA-like transporter family. This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.	0.000528729
NC_008578.1\|WP_011720216.1\|1538897_1540289_-\|protoporphyrinogen-oxidase	gnl\|CDD\|237009	PRK11883, PRK11883, protoporphyrinogen oxidase; Reviewed.	1.56303e-143
NC_008578.1\|WP_011720233.1\|1562488_1563163_+\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	3.99279e-41
NC_008578.1\|WP_041835564.1\|1553508_1555404_-\|1-deoxy-D-xylulose-5-phosphate-synthase	gnl\|CDD\|235470	PRK05444, PRK05444, 1-deoxy-D-xylulose-5-phosphate synthase; Provisional.	0
NC_008578.1\|WP_011720234.1\|1563253_1563955_+\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	4.46284e-46
NC_008578.1\|WP_083760636.1\|1560191_1562354_-\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.6735e-26
NC_008578.1\|WP_011720217.1\|1540285_1541392_-\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	7.28021e-178
NC_008578.1\|WP_011720229.1\|1555627_1558408_-\|aconitate-hydratase	gnl\|CDD\|236445	PRK09277, PRK09277, aconitate hydratase AcnA.	0
NC_008578.1\|WP_083760635.1\|1550058_1550796_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.56561e-56
NC_008578.1\|WP_148204677.1\|1551000_1552212_+\|HRDC-domain-containing-protein	gnl\|CDD\|223426	COG0349, Rnd, Ribonuclease D [Translation, ribosomal structure and biogenesis].	3.42222e-73
NC_008578.1\|WP_011720214.1\|1537787_1538189_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|376583	pfam01641, SelR, SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.	1.42593e-80
NC_008578.1\|WP_011720220.1\|1543621_1544503_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213236	cd03269, ABC_putative_ATPase, ATP-binding cassette domain of an uncharacterized transporter. This subgroup is related to the subfamily A transporters involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two integral membranes. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.59773e-96
NC_008578.1\|WP_049751621.1\|1538194_1538842_-\|chlorite-dismutase-family-protein	gnl\|CDD\|377705	pfam06778, Chlor_dismutase, Chlorite dismutase. This family contains chlorite dismutase enzymes of bacterial and archaeal origin. This enzyme catalyzes the disproportionation of chlorite into chloride and oxygen. Note that many family members are hypothetical proteins.	6.41609e-90
NC_008578.1\|WP_011720222.1\|1545332_1546436_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.66789e-42
NC_008578.1\|WP_011720219.1\|1542407_1543625_-\|ABC-transporter-permease	gnl\|CDD\|224582	COG1668, NatB, ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism].	5.84126e-20
NC_008578.1\|WP_011720231.1\|1559001_1560195_-\|class-I-SAM-dependent-RNA-methyltransferase	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	6.50394e-94
NC_008578.1\|WP_011720221.1\|1544672_1545290_+\|DUF3000-domain-containing-protein	gnl\|CDD\|378665	pfam11452, DUF3000, Protein of unknown function (DUF3000). This is a bacterial family of uncharacterized proteins.	8.35208e-78

>NC_008578.1|WP_011720223.1|1546432_1547920_-|hypothetical-protein
MSPTWRLRLVAILAIGASLPLAAATHWGHPALWALPLLVILVAAANILRISITIARMLVTFTMTEGVLAGAFLLAPGWWIVPATCLGLFPALLRQRSSPLKVFYNLAQYFLTGTLAAYTAVHLHGGVVACAAAMAIWWMTDQVMSAIPLSIMGRQSLRAMIFEDAGVYAVHAAGTTSVGLLASWLMVHAPFGLLGLLVPVFLLWVAFDEQTSKSAEARLFAELARGQEQAVTHSVDISARVVLTAAARVLGGADVELVVLEHEGPVVYTGDESGQTQRRPDPHAFDQPWALRALGARGVLVGSEEGRPFCSAVIGKHDRPLAVMIARRAEGSSSFGRREVALVKVLVGQAKSWLSVADLAAARDRAMARAHAADQAARSLGDLGADTAPALDMLRESATRLARLASTGSNDAVREIVEELHAVERAVASLLGAIALAADPALRELDATPSAPVRREGEWTTTGLLPGTAKPDGVAPGIRLPEAAQPDNEQTQSVR
>NC_008578.1|WP_011720222.1|1545332_1546436_-|sensor-histidine-kinase
MKPFRGHGFPLAVWTSGLAAASGVAALIVVTLGLVAADRLDAASWLALGVALVVTALCAWVGYRAGRRFAVALRHLRENATHRLEDAHAPLVGDSKDHVLVSAVPELLELARALEALHLRIRVSDDVAARHRQLAETASAGMFELLSGLVEAEESARGQLSAELHDTVAQTLMLARSLLTSPVVEPSDLVTIRELVAEAEDQVRAVMARTRPPALRDGDLAQAVLALRDDLRTRYGLEVLIEWPSSPYPLPLVTAVTVYRFFQEGLLNVVKHADVDIARISLTVDETHVVAVVHDDGPGFDPEQVRPERGRHVGLGLLRERVRLAGGSLDITSWPQPGTTLTLRMPRGAPSGPLAPSNRRSEPVPSS
>NC_008578.1|WP_011720221.1|1544672_1545290_+|DUF3000-domain-containing-protein
MASRQRPSEPPEAFARAIAGLRAVRLRPEIRLAEAPAPQRLAPFALAFTGDIDAAGEELATGRFVVLHNPAGEETWQGDTRVVVYVRALLEPEMANDPFLPAVAWTWLTEALTHRFEPAMPVALGGTVTRVLSESFGTMSSRPPSAHVELRASWTPSGDLTAHLEAWGEVLASAAGLPPLPPGVAVLPPPGDARRTAATRPPRRR
>NC_008578.1|WP_011720220.1|1543621_1544503_-|ABC-transporter-ATP-binding-protein
MLELRSITKAFGPRRVLDAVSMTLRPGEITGFVGANGAGKTTTMRIVMGLVPYDSGALLWDGAPLRLEEQRTFGYMPEERGLYRKQPVREQLLYFGRLHGMSKRQAAQRADELLDIFGLTSRAGDKLEQLSLGNQQRVQIAVALMHRPRALILDEPFSGLDPDAVHAMAGLVRSAAAEGVPVLFSSHQLDLVERLCDQIVIISAGRIVAAGSADALRARHAPLMRLDAPAVGEWIHEMPGITVTEKTADRVVFIPETPQRAQAVLQRALQSGPVTHFAEVIRPLSEIYQEVTR
>NC_008578.1|WP_011720219.1|1542407_1543625_-|ABC-transporter-permease
MIRRFRRAFRRAAWPLVAGREIRVSATSMAVRVSTGITLLAVLGGIIAVHFLTNRVTTYRVGAVSADASAIVQTVAGRHGTIVIREQEFSDRQSAEAAVRSGRIDAALVPPRDGSGWLVVAKRTPSATLVAYLTQAVQRGVLQDAAVRAGLAPNALIAASRVTPVALVPQRQDQAADRVIAAAFGVLFFVSCQLFGTAMSTGAAEEKESRVVEVLLAAIPARALLAGKIVGNVAVAFAQMTLYAAAAAAAAAAVGGIPHLDAILRSGGWFLLFYLVGFTTVAFLFAGLGALASRIPDVPAATMPIQLLVIATYIFALIGKGAAVTVASFLPVLCTVAMPQRIFAGHVPGWQVGLALLAAVLFSGLALTLASRIYQVAALHSGVRLRLLSTLRSASRRPAPASAGS
>NC_008578.1|WP_011720218.1|1541446_1542298_-|DMT-family-transporter
MAAFLALFASVTWGCSDYVGGVVSRRHQPLVVVALAYAIGAAVLLPIAAASGAFTSPLGYLPWALAAGVVGLLGLGAFYRALATGTMGVVAPIAGAGAGIPVIVGIARGEAPSAAQILGIAAAVVGVILAGGPELRSGGTRRPILLAALAGGCFGTVFVLLAGGAKTSVVMTLLIMRLTSVVLFLAGVGFFRVRSRRPRMPVRGWPMGDVTRVLFVGCADVAGNGLYAVASRSGLMSVVAVLASLYPAVTVLLARFLDGERLRHIQTTGIVLVLAGIPLLAAG
>NC_008578.1|WP_011720217.1|1540285_1541392_-|uroporphyrinogen-decarboxylase
MADVLPRSDGALLRVCRGEPAPVTPVWFMRQAGRALPEYRAARGETPMLQACLDRDLIVELTLQPVRRYRVDAAILFSDITVPLALSGVSLRIEPGVGPVFDQPVRRAADVARIRPLDRGSMTPIVEAVRLLVGELAGIPLIGFAGAPFTLASYLVEGGPSRDHAVTKALMYSDPATWHALLDRLADISREFLLAQIDAGVSVVQVFDSWAGALHPDDYRRYVAPHSGKLLAGLPVPRIHFGVGTGELLPQFRAVGADVVGVDWRVPLDVAARRIGADAVVQGNLDPAVVFAPWPVLEAAVRDVLIRGRAARGHIFNLGHGVLPSTDPGVLAAIVDFVHAWSADRSARGVPTAVDRFGSEHPAAEAAG
>NC_008578.1|WP_011720216.1|1538897_1540289_-|protoporphyrinogen-oxidase
MTARIVVVGGGIAGLSAAFYARRRGFSVTVLEGSKRFGGKLLRAEVAGVSTDLGAEALLARRPEAVDLAREVGLGGELVPPATTQAAVYSRGRLRPLPAGHVMGVPRSLRSLAATGIVPPTAVLRAAADLLLPPTPVGDDVPVARGIGIRLGRGVVDRLVEPLLGGVYAGRADRLSLRATLPQLVDVLDRGSLLRGLRDLPPPGGADPVFAGIPGGVARLGEALVDVLRADGVELRTSAMVRVLRRTPTGWRCDVGPASAPEAVDADGVVVAVPAPAAARMLGPEAGGLAAELAGIEYASVAVVTLAFPADQVNLPAGSGFLVPAVERRLVKAATFSSVKWPWYAGSDVAVVRCSIGRFGDTADLQRDDAELVAGVLADLGAIVRLRAQPIDSIVTRWAGALPQYDVGHAARVARIRSAAARLPGFALCGAAYDGVGIPACIAGAQRAVASLTGPRSVSRTAG
>NC_008578.1|WP_049751621.1|1538194_1538842_-|chlorite-dismutase-family-protein
MYAVLRGRPGALADLDRSHVSAEVENLLAEAAGKGVTTRGVYDISGFRADADVLIWWIGGEAEALQDAYQRLRRTAFGQACEPAWTAIGVHREAEFNKAHIPAFLAGEAPKKYVCVYPYNRDHEWYLLPAAYRADMLAEHGRMGREYPDVLANTVAAFALGDYEFLLAFEADELHRIVDLMRRLREARARRHTRLETPFFTGPRRPVAEIIAALP
>NC_008578.1|WP_011720214.1|1537787_1538189_+|peptide-methionine-(R)-S-oxide-reductase-MsrB
MERIIRSEAEWRAQLSPAEYAVLREAATEPPFSGEYVNTTTPGVYVCRACGAELFRSETKFDSHCGWPSFYAPQDTDAVELLPDHSHGMIRTEVRCRRCGSHLGHVFHGEGYPTPTDDRYCINSIALRLVPED
>NC_008578.1|WP_083760635.1|1550058_1550796_+|response-regulator-transcription-factor
MTPGDTGSGKPTSTSRGGTRVTALAEHVPPQPGNSAGFTAMVVDDHPLVRESMVSRLTAMGAREVIEAASCAEARARARSVGPCDVCIVDVGLPDGSGLDLIAELRAAGWPRLVVLSAADDPYSVRAAFVAGAQGYLLKSASPVVVTDGVRRVLDGGVYADPAVASLLAAGLRNNASNEGIGDLSSREIEVLRLVADGRSNKEIGDQLGLSALTVKSHLARIARKLGTGDRAEMVALAMRAGIIR
>NC_008578.1|WP_148204677.1|1551000_1552212_+|HRDC-domain-containing-protein
MSLRDGTPDVVDTPEKLAAAVRALAAADGPVAVDAERASAYRYGHRAYLVQLRRPGAGTFLIDPLPFANLRPVHEALSTAEWIVHAAAQDLPCLAELGLRPARLFDTELAARLAGYPRVGLAAMVEELLGFRLNKDHARVDWSRRPLPESWLRYAALDVEVLVELREILHTELQRQGKLRWAVEEFEHVRTAPPPSSPVERWRRVSGIHQVRGRRQLAVVRELWHARDRRARELDMSPGKVLSDSAIIRAATGKFRSKKELAATPEFSARPAREFLDEWWDAIGRATACGEAELPAPTPNIDGPPPAHRWSEASPDAAARLSVAKTVVAALADEHRLPAENLLAPDVVRRLAWQPPHSLDDHAVATALRRLGARPWQVGLTAEPLAKALRRVELHELRHSTSP
>NC_008578.1|WP_011720227.1|1552469_1553345_+|hypothetical-protein
MAPARNQSDAESSASSVALRQCLLAVSVTADIDLTPTDDGAVIAGVPVVRLTFSEVAEAIRNAAPQTALARRRLLRWIRLRRALAERSIDELAESARPVGLPIGHELHPGPDWVCEHILGGCLDLGIGIVGLDDADPQRVVVVPPGVFRATNIDTTEWWRAAYEYLENMGALATVRWRREPRRPLHPMGDCDVVTLLGSAVFRGAIAADAGGMRAVAAPMRHRGWLELSRIDPAFVRAAAMLTDDENRGFVRPVLVTADEVCLAGDGDGVRIVLRDPAARDERWLRDVLYH
>NC_008578.1|WP_041835564.1|1553508_1555404_-|1-deoxy-D-xylulose-5-phosphate-synthase
MGLLESVNTPEDLRALDHAQLTRLAGEIRDFLVQAVSRTGGHLGPNLGAVELTIALHRVFDSPSEPILFDTGHQAYVHKILTGRRDGFAMLRQRGGLSGYPSRAESEHDWIENSHASTALSYADGLAKALALRGERRTVVAVVGDGALTGGMCWEALNNIAAAKDRSIVIVVNDNGRSYAPTIGGLAAHLNALRTNPNYEKVLARVKDVLSRTPLVGEALYDTLHGIKKGLKDVLTPQGLFEDLGLKYLGPIDGHDIGAMEHAFLQAKRFGGPVIVHCVTRKGYGYAPAERDEVDHLHGPGAFDPRTGKEMPKPRSWTAVFSEEIVRIGADRPDVVALTAAMLHPVGLAEFAAAYPDRVFDVGIAEQHAVTSAAGMAMGGLHPVVCVYSTFLNRAFDQVLMDVGLHGLPVTFVLDRAGITGDDGPSHNGMWDLAILSLVPGMRIALPRDARRLRELLHEVLAVSDGPTAIRFPKGELPADVEAVDRIGGVDVLRQADDAEVLLVGYGPMSHVALEVADRLAAHGISATVVDPRYLLPMDPALLTLCAAYALVVTIEDNCRQGGAGATLSLALRDKGVDTPVRIHAIPQRYLAHGKRAQVLADIGLSAQDIARSVVETVASLGSLDRQPVID
>NC_008578.1|WP_011720229.1|1555627_1558408_-|aconitate-hydratase
MTEANSFGSRSTLAVGDARYTIYRLDAVPSVHRLPFSLKVLLENLLRTEDGVNVTADHIRALANWDPDKEPDTEIQFTPARVLMQDFTGVPCIVDLAAMREAMVALGGDPKRINPLSPAELVIDHSVIADVYGRPDAFVRNAELEFQRNRERYQFLKWGQRAFDNFKVVPPDTGICHQVNLEYLSRVVFDRDGVAYPDTLVGTDSHTTMVNGLSVLGWGVGGIEAEAAMLGQPISMLIPKVVGFRVHGELPDGATATDLVLTVAEMLRRHGVVGKFVEFYGPGVGNIPLADRATIGNMSPEYGSTCAIFPIDDETLRYLRFTGRSPERVALVEAYAKEQGLWHDPEHEPEFSERLELDLSTVEPSIAGPKRPQDRIPLTGAKRAFRSALRNYVTDEPADGSLDEGLAESFPASDPVAVEHEHPGDKPRVVASAAQGSNGRPSKPTLVTLSDGTTVELDHGAVVIAAITSCTNTSNPSVMIGAALLAKKAVERGLTPKPWVKTTLAPGSKVVMSYYEAAGLVPYLEKLGFALVGYGCTTCIGNSGPLDEPLSRAINESELAVASVLSGNRNFEGRIHPDTKLNYLASPPLVVAYALAGSMDVDLTTEPLGIGADGNPVYLRDIWPSEQEISEVMGRAIESRMFVESYRDVFAGDERWNSLQVPDGELFVWDETSTYVRRPPYFDGMTPEPAPLADIVGARALVMLGDSVTTDHISPAGSIKRDSPAGRYLMEHGVQPKDFNSYGSRRGNHEVMIRGTFANIRLRNLLAPGTEGGVTRHLPDGELMTVYDAAMRYAAEGVPLIVLAGKEYGSGSSRDWAAKGTALLGVRAVIAESFERIHRSNLIGMGVLPLQFVDGQNRESLGLTGEETYTIAGLAGADHIPRQLVVRADDKEFPVIVRIDTPGEAEYYRHGGILPYVLRSILARPA
>NC_008578.1|WP_041834997.1|1558570_1559005_-|hypothetical-protein
MMHATLLLCDAAEVDPAGKVHMLGAGWTVVGAGPTGALPGQAVVVLVHVPWHRTGEDHLLRLSLEDADGRAVLAGAPENPQPLVHQQAFRVQRPPGAPEGITIDVPVVVTIGPGLVLPPGRYAWRLEIDGETREDWLVSFHVRA
>NC_008578.1|WP_011720231.1|1559001_1560195_-|class-I-SAM-dependent-RNA-methyltransferase
MSAVGDRLELTIGPVAHGGVCVARHQGRVVFVRHTLPGERVVARLIDVRSRFARADVIDVLDPSPHRVAPACPYAIPGGCGGCDWQHAEAAYQRQLKSTVVGEQLTRLAGLQREVAVEPTGTDLGWRTRVQFAVDDQGRAGFHPWRSHAVLPVERCAIAHPAVEALDIEGRRWPAARAVEAAVGVATGSHSVLVTRSDGRRRLIGDRRLIEVVRGRRFRLRPTTFWQVHPAAADLLIGAIVSGVTPAPGERVLDLYAGAGLFAAFLAESVGSSGRVVAVEGDRGAAADASVNLAEFDTVEVRRADVAEFLAAAADRGERFDIVVADPPRTGLGPPNARRICALRPRAIGYVACDPAALARDLAVFSEAGYQAVSVRAFDIFPQTHHVECVAILRPEP
>NC_008578.1|WP_083760636.1|1560191_1562354_-|APC-family-permease
MVDSFGVPACREPGPSWHALGRRSARPRCSGAAAHCARRPLATIVRVPFPGGVLKRLLVGRALRSDRLGETLLPKRIALPVFASDALSSVAYAPDEIFLTLSAAGFAAYAFSWKIAIAVAVVMVTVVASYRQTVRAYPNGGGDYEVTSHNLGATVGLVVASALMVDYVLTVAVSISSGADYAASAIPLLKGHTAALAVGLVVVLMAMNLRGIRESGTAFAIPTYAYMIGVLGMALVGFVRAALGTLPQAETARIPVPPSTEFPHGLTGLLGAFLILKAFSSGSAALTGVEAISNGVPNFREPKSKNAATTLLLLGTIAVTMMFSVVVLARITDVHRFAARQDPIISQLAKAAFSGFSPGFYFVATATGVVLVMAANTAFNGFPVLGSILAKHGYLPRQLQNRGDRLAFSNGIILLAGFAVLLIVVFDAQTTRLIQLYIVGVFVSFTASQIGMVRHWNRHLRTVTDAAERRRMIRSRAINAFGATMTGIVLFVVLVTKFLAGAWISVAAMSVIFLTMRGIRGHYDAVSRELFANLDAETALPARVHAIVLLSKLHKPALRALAYARATRPSVLEAVIVDVDPEETAALVQEWEQRGIPVPLKVLASPYREITRPIVEYLRSIRRRSPRDVITVFIPEYIVGRWWEQLLHNQTALRLKGRLLFTPGVMVVSVPYQLKSSERLTAQLEDAATWWHTATASPTDLPADGRPPVELPTRPGPPES
>NC_008578.1|WP_011720233.1|1562488_1563163_+|TrkA-family-potassium-uptake-protein
MHVVILGCGRVGATLANSLERLGHSVAIIDQDAHAFRRLPPDFRGRKVHGFGLHRSVLEESGIRHASAFAAVSNGDNSNIISARLAREVFGVENVVARIYDIRRAEIYQRLGIPTVATVKWTADQILRRLLPSGLQTVWRDPTGTMALGEVHVDPSWIGRPLTELEGAAGARIAFVTRFGAGVLPTPETVLQEGDLVYLLAPETHLREAAEILGRPREAEREHA
>NC_008578.1|WP_011720234.1|1563253_1563955_+|TrkA-family-potassium-uptake-protein
MRVAIAGAGAVGRSIAAELVENGHEVLLIDKDSKAIDVDAIPRAEWMLADACEIASLDEVGLDRCHVVVAATGDDKVNLVVSLLAKTEYGVPRVVARVNDPVNEWLFDESWGVDVAVSTPRLLSALVEEAVSVGDLVRLMTFRRGQANLVEWTLPPSAPLIGKRVGSVSWPPDTALVVILRDGRVIVPSPDDPLEGGDELLFVAAPEVEEQLRALLLRGSQPPSDQAAAAGAR

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Crispr_ID: NC_008578_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_9

1654488-1654581

Orphan

Consensus_repeat	Method
CCGCACCGGCGGTCGCACCACCCGAACGGA	CRISPRCasFinder

1 spacers

DinG

The CRISPR arrays of NC_008578_9

>merge|NC_008578|9|1654488-1654581|CRISPRCasFinder
CCGCACCGGCGGTCGCACCACCCGAACGGACGTGAGGCGCCAGGGAGGCCCGCCGACTCGGTCTCCGCACCGGCGGTCGTACCACCCGAACGGA

>NC_008578|9|9|1654488-1654581|CRISPRCasFinder
CCGCACCGGCGGTCGCACCACCCGAACGGA	CGTGAGGCGCCAGGGAGGCCCGCCGACTCGGTCT
CCGCACCGGCGGTCGTACCACCCGAACGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_169303200.1\|1663288_1666096_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NC_008578.1\|WP_011720312.1\|1658917_1659430_-\|transcriptional-repressor-NrdR	unknown	unknown	gnl\|CDD\|234774
NC_008578.1\|WP_083760544.1\|1667885_1668881_-\|diaminopimelate-epimerase	unknown	unknown	gnl\|CDD\|234768
NC_008578.1\|WP_011720301.1\|1642551_1644198_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235906
NC_008578.1\|WP_011720305.1\|1646310_1649304_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NC_008578.1\|WP_148204680.1\|1666311_1667823_-\|GTPase-HflX	unknown	unknown	gnl\|CDD\|274455
NC_008578.1\|WP_011720300.1\|1641566_1642394_-\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NC_008578.1\|WP_011720310.1\|1654589_1655525_+\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|239116
NC_008578.1\|WP_041835007.1\|1650967_1652209_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341031
NC_008578.1\|WP_011720304.1\|1645452_1646301_-\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197320
NC_008578.1\|WP_011720302.1\|1644230_1644665_-\|DUF1707-domain-containing-protein	unknown	unknown	gnl\|CDD\|377959
NC_008578.1\|WP_011720303.1\|1644844_1645453_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NC_008578.1\|WP_011720308.1\|1652293_1653316_-\|zinc-dependent-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|176247
NC_008578.1\|WP_011720309.1\|1653857_1654313_+\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107221
NC_008578.1\|WP_041835594.1\|1649584_1650808_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_008578.1\|WP_011720314.1\|1660254_1661082_+\|transcriptional-repressor-LexA	unknown	unknown	gnl\|CDD\|234688
NC_008578.1\|WP_011720311.1\|1655558_1658855_-\|vitamin-B12-dependent-ribonucleotide-reductase	unknown	unknown	gnl\|CDD\|235828
NC_008578.1\|WP_148204679.1\|1661159_1662839_-\|ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|224120
NC_008578.1\|WP_011720313.1\|1659727_1660042_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NC_008578.1\|WP_041835600.1\|1668775_1669714_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_169303200.1\|1663288_1666096_-\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	2.2243e-114
NC_008578.1\|WP_011720312.1\|1658917_1659430_-\|transcriptional-repressor-NrdR	gnl\|CDD\|234774	PRK00464, nrdR, transcriptional repressor NrdR.	2.61896e-78
NC_008578.1\|WP_083760544.1\|1667885_1668881_-\|diaminopimelate-epimerase	gnl\|CDD\|234768	PRK00450, dapF, diaminopimelate epimerase; Provisional.	4.13764e-91
NC_008578.1\|WP_011720301.1\|1642551_1644198_-\|hypothetical-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	6.10915e-06
NC_008578.1\|WP_011720305.1\|1646310_1649304_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	2.86519e-67
NC_008578.1\|WP_148204680.1\|1666311_1667823_-\|GTPase-HflX	gnl\|CDD\|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	2.1563e-170
NC_008578.1\|WP_011720300.1\|1641566_1642394_-\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	4.52838e-78
NC_008578.1\|WP_011720310.1\|1654589_1655525_+\|nucleoside-hydrolase	gnl\|CDD\|239116	cd02650, nuc_hydro_CaPnhB, NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. .	1.0333e-104
NC_008578.1\|WP_041835007.1\|1650967_1652209_+\|MFS-transporter	gnl\|CDD\|341031	cd17478, MFS_FsR, Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters. Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.36679e-25
NC_008578.1\|WP_011720304.1\|1645452_1646301_-\|exodeoxyribonuclease-III	gnl\|CDD\|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	3.6738e-121
NC_008578.1\|WP_011720302.1\|1644230_1644665_-\|DUF1707-domain-containing-protein	gnl\|CDD\|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	7.50887e-22
NC_008578.1\|WP_011720303.1\|1644844_1645453_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	9.39942e-10
NC_008578.1\|WP_011720308.1\|1652293_1653316_-\|zinc-dependent-alcohol-dehydrogenase-family-protein	gnl\|CDD\|176247	cd08287, FDH_like_ADH3, formaldehyde dehydrogenase (FDH)-like. This group contains proteins identified as alcohol dehydrogenases and glutathione-dependant formaldehyde dehydrogenases (FDH) of the zinc-dependent/medium chain alcohol dehydrogenase family. The MDR family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. FDH converts formaldehyde and NAD to formate and NADH. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	0
NC_008578.1\|WP_011720309.1\|1653857_1654313_+\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107221	cd06464, ACD_sHsps-like, Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.	1.06122e-30
NC_008578.1\|WP_041835594.1\|1649584_1650808_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.59114e-56
NC_008578.1\|WP_011720314.1\|1660254_1661082_+\|transcriptional-repressor-LexA	gnl\|CDD\|234688	PRK00215, PRK00215, transcriptional repressor LexA.	1.51783e-109
NC_008578.1\|WP_011720311.1\|1655558_1658855_-\|vitamin-B12-dependent-ribonucleotide-reductase	gnl\|CDD\|235828	PRK06556, PRK06556, vitamin B12-dependent ribonucleotide reductase; Validated.	0
NC_008578.1\|WP_148204679.1\|1661159_1662839_-\|ATP-dependent-DNA-helicase	gnl\|CDD\|224120	COG1199, DinG, Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair].	1.05482e-111
NC_008578.1\|WP_011720313.1\|1659727_1660042_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	1.05228e-08
NC_008578.1\|WP_041835600.1\|1668775_1669714_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	1.6745e-136

>NC_008578.1|WP_011720309.1|1653857_1654313_+|Hsp20/alpha-crystallin-family-protein
MALPVRATRNRAPARLDLFREFDELTDRLNQLWENTFGSLASDPWWSPLADIEETDDAYTVEIDLPGVKRDDVTVEFHNGELRVSGEIKERERTGILRRQTRRTGHFQYAVHLPGEIDVDKVTAQLTDGVLTVRLPKVAAAKGRRIEITSG
>NC_008578.1|WP_011720308.1|1652293_1653316_-|zinc-dependent-alcohol-dehydrogenase-family-protein
MRGVMLYAPRDVRVVDRADPVCVEPTDAIIRLAATCICGSDLWPYRGIDRVDGPVPMGHEYVGFVEDVGAAVTTVRRGQFVVGSFFASDNTCEICRAGYQSSCVNRQPMGELGAQAEYLRVPLADGTLVATPAAPPDDLVPSLLAASDVLGTAWFAADAAQVSPGKTVVIVGDGAVGLLAVLAARHRGAERIIVMSRHEERQKIAWEYGATEIIPERGDDGVARVKALTNGLGAHCAIEAVGTQEAMMQAIRATRPGGHVGYVGVAHGVQLPGDELFFSHVHLHGGPAPVRRYLPELIDLIWSRRIDASRVFDLALPLAEAARGYQAMDERRAVKVLLTP
>NC_008578.1|WP_041835007.1|1650967_1652209_+|MFS-transporter
MPDWRPGDRFQIALLTVAHAVQHFSAAVLAFSYPFVVAYFHVSYAVLGVVLGVTGVIGGLLQGIAGLLRRIPARTLLVGQDIGLAASLLLGALSPVFAVFALAKALGSLVQWPQHPIGSAYLSERVPHRRAFALSWHTIGGSIGTLAVPLIAGFVTARWGWRWSLGVFVPPLLLGAAALWFGMDRDVSPSSDDETAVPVVEQGRNAPPVDAAQSLGAVLRRPAALAALAAGTVAAAGRGLGVLGAYVPAFLRDGAHLGSVLVGVLYTVMLVGSVVGPAGAGWLADRVGRRTVLLVVYPAAALFLVLYVFVGATLWALAVVGLFVGVFAYAESPLIQALFADTTAGAAARSVFGVYFAIAYGVGALWQVIIGWLVSSYGFRTAFIVMAISFVAAGLCVAGAREQPAGDRTRAAA
>NC_008578.1|WP_041835594.1|1649584_1650808_+|MFS-transporter
MSLWRHRNFRRLWIGETVSHFGTQVSVVAIPLVAVTTLHAGALAVGLLSTLETIAFAVLGLPAGAWCDRWRRRPVLITADVGRAIALATVPIAAAFHVLTFGQLCAVVTVSGVLTVFFDVDYQAFLPTLVGRDHVVAANGALEASRSAAALGGPSLGGLLAQLFTAPYAVAADAVSFAWSAAWIAAIDAAEVRKPRAQSSTGREILDGLRFVFGHRLLRMLAGSTASFNLFNGLTNAVVVLFLVRTVGLSAGSIGVLFSAAGLGGLAGALVAHRLNRSLGYARMIRGSAAIVALLAPLLPLTDRGWRLSLFVVWSLVGSAAIAAYNIATVSLRQVLCPPELLGRMNATMRFVVWGTLPLGSLLGGALGANLGLRGALWVAAIGTLGSPAWVFASPLRAGQPVTEGVF
>NC_008578.1|WP_011720305.1|1646310_1649304_-|FAD-binding-oxidoreductase
MSGRFAASTGSPEHRDLIRALRSVMRGPVDASSRRRAEYSSDASNYRVVPAVVAYPQDASDVCAAIDVARRFHIPVTMRGGGTSVAGNAIGPGIVLDTSRFFRRILDIDPSGRTAYVEPGVILADLQKALRPHGLRFGPDPATANRATIGGALGNNACGSHALAFGRAADNVIEMDVVDGTGRRFTVGSGWEPVPGLARLVEENAAIIRTEFGRFSRQISGYGMEHLLPEKGRFLARALVGSEGSAVLVLGARVRVVDIPRHTALAVLGFPDLIAAADAVPIVLRHAPLAVEGLAARLVDVIRRAGRPVPTLPDGGGWLLVEVGGASDDHAVSRARRVVADVRPMSSAVLTDSAQAAAIWRIREDGAGLVGRFARSGGAWPGWEDAAVPPENLGPYLRDFTRLLDEFGIDAIPFGHFGDGCVHTRLDVPLTTAGDVERFRSFIDEAADIVCAYGGSFSGEHGDGRARSRLLPRMYSAQAMRLFADFKRLFDPEGILNPGIIVHPPPLDADLRRPLAADIAAATGFRFTADAGSFTRAVHRCVGIGKCRADYRDSGTFMCPSYLATRDEKDTTRGRARVLQELAVAARGGRRAVARSFRTGDVHDALDLCLSCKACASDCPTGVDMARYKSEVLYRAYRWRLRPRSHYTLGRLPSWLRLVRGMPALSRRLLRAEPAVALLRFLAGIDPHRSLPLPARRGFRPGDVRPWLDDSGDPAGSGEAGTAVLWVDSFTQTFAPHVAAAAAWLLTTAGYRVRLPDRQPCCGLPWITTGQLRAARRRLAGLVDVLHPAAAEGAIIVGIEPSCTATLRSDLPDLLADPRAEQIAHATRTLAEALLAARWQPPQLDGVHLLVQPHCHHYAVIGYDADRALLGQTGAQLTEAAGCCGMAGNFGMEKRHYAVSRRIAELGVLALLANRPDSVVVADGFSCRTQLADLADCHAVHLAELLAGAAGTADGAARTEDSAAGTADGGAAGTADSAAAGGAADLDAGADGGPAPR
>NC_008578.1|WP_011720304.1|1645452_1646301_-|exodeoxyribonuclease-III
MRIATWNVNSVVARLPRLHEWLDTVRPDVVCLQETKCAGDAFPSEGIIERGYQVAAHGDGRWNGVAILSRIGLEEVTRGFPGQPGYAAPPAAPSPDSDDALLPAAAAEPVVEARAIGATCGGVRIWSLYVPNGRALDSPHYAYKLEWLAALRTALAAELARHSGRPFIVAGDFNIAPTDRDVWDPAVFVGSTHVTDAERQALQAICDLGLRDIFPRALKYDYPFTYWDYRAGMFPKNQGMRIDLVLANDAAAAKVTDAYVDREARKGKGPSDHAPIVVDFAL
>NC_008578.1|WP_011720303.1|1644844_1645453_-|GNAT-family-N-acetyltransferase
MSSAAGFPPPGSSGDAPASAPADGRADPLTFRTATQDDIPAVVALVESAYRGDASRAGWTTEADLLDGQRTDADAVAAIVADPASRILLALDSSGRLVGCAQLTVRADGTVYFGMFAVRPGRQGTGLGTRILAEAERQAATLWNATAMEMTVIEQRSELIAWYERRGYRRTGERRPFPYGDERFGIPKRPDLVFAVLRKELR
>NC_008578.1|WP_011720302.1|1644230_1644665_-|DUF1707-domain-containing-protein
MANSGYLRIGDAERDQAIELLGRHFADGRLTQEEYEERLSAALRARTRADLTALFSDLPQLPPAVPAVRPRRIMPWLIPVACCLLLALALLVAVDHGIAPFLVVLGAFVVIGGGRRRGRRASSGGWPPRHDVESPGGWRRGGAS
>NC_008578.1|WP_011720301.1|1642551_1644198_-|hypothetical-protein
MTVALTGCTGDHHTAEPSSQPRPQPSSDVSSPPAPPAHAHPTHPTTPVTVISERTPAAATAALATVLFSAADLVVLSADDAADIAQAAQTATAQCAPLLVVDTAGPPVATLLHLHTRQVITYGTITGPPPGISIVGPPADMPSINGDGDHEPSTPPADQAQPTAPATRTERSMTTPPDAGQPTAAGSRQSPSAGSHHSPAAGGTADLRDTAVLVDRSDGRLARAVTPTAQAAGVRVVEVQGTDPRADPGAIAALHALQPRYTVAVGDFGPPALLASRLAVAGTGLQLPAGGQVIFPGRRFVALYGHPDTPALGVLGAQDLPASVQRAEELAARYQALSDVPVVPTFEIIAAVAQRNPGADGDFTAETDPAELRPWVEAAQQAGMYVLLDLQPGRADPLRLAQRYAALLAYPYVGLAVDPEWALAPGVAPLQRIGSLDAQVLNSVAAWLDGFTAARHLPQKLFVIHQFQLSMIRNERALRVRYDNLAVLIHMDGQGSPPDKEATWRSVVGAAPAGVSLGWKNFYREDHPMLSPEQTMAHQPSPLMISYQ
>NC_008578.1|WP_011720300.1|1641566_1642394_-|LLM-class-F420-dependent-oxidoreductase
MEIGVAIFATDDALDPASVARLAEERGYESLFFPEHSHIPAARLTPYRGGGDLPRRYWRTYDLFVALAAAATATRRLRIGSGICLVVQRDPIYLAKETASIDHLSGGRFEFGVGAGWNREEMLNHGTDPKVRMHILRERIEAVKVIWSEAEASYRGRYVNFEGICSWPKPLQRPHPPILVGGRGPTVFDRVLSYGDGWFPNHAGDVIERSRELLARADRRISLQVMGVPADPHVLEAYEKAGFDRAVHWLPSAKRSVIERAMDDFERAVAEYRGH
>NC_008578.1|WP_011720310.1|1654589_1655525_+|nucleoside-hydrolase
MKRILLDCDTGIDDALAIIYGIRHGAQFAGIGSVHGNVPAPLAAANTLRVLDVLGAAEIPVRVGAARPIAQPLCTAEHVHGADGLGNTNLPPPKRSPYPGSAAEQIVSLAHRFPGELTLVAIGPLTNVALALLLDPELPALIPDVIVMGGVVQPPGNVTPLAEANIWHDPEAAALVIEAAWSVTFVTLDVTMRTLLREDQLAAIANAATPHGRFAWSVLQFYLDAYERRLATRTCPLHDPLALALALDPSLATYRSLPTRIELRGETSRGMAVCDLRGPQADRDSSWHDVRYVAELDIETFHHRFLDALLS
>NC_008578.1|WP_011720311.1|1655558_1658855_-|vitamin-B12-dependent-ribonucleotide-reductase
MTEPTSGARAQMDGSGRRGLTMQRIYTTPGVHPYDEVNWVRRDVVMTNWRDGSVNFEQRGVEFPDFWSQNAVNIVTTKYFRGALGTPQREWSLKQLVDRVVKAYAKAGLENGYFATPDDATIFEHELAHALVHQVFSFNSPVWFNVGTPAKQQVSACQPYSAPVSTPDGPIPIGKLVDANAVGEKVFDASGVTRIVATTCNGRKPVLRIRTSGGHVLDVTPDHLVWQVVDQTAGRFVPAGQLRVGDRLEWHDRANSDAMVAAFTADSAAAAQPGQIVDILAIDELGVMPVYDIQTESGEYLSDGIRVHNCFILSVDDTMESILDWYKEEGLIFKGGSGAGVNLSRIRSSKELLSSGGTASGPVSFMRGADASAGTIKSGGATRRAAKMVILDVDHPDIEEFIETKVREEEKIRVLRDAGFDMDLGGRDLYSVQYQNANNSVRVSDEFMRAVERGESFGLRARTTGEVIETVDARKLFRKMAEAAWACADPGIQYDDTINDWHTCPESGRITASNPCSEYMHLDNSSCNLASLNLMKFLTDDGRFDIDTFIKVVELVITAMDISICFADFPTEKIADTTRRFRQLGIGYANLGALLMATGHAYDSDGGRALAAAITSLMTATAYKRSAELAAIVGPYDGYARNAEAHKRVMRKHAAASDALRTIGEMDRAIAERACQMWRECLTLGEQHGWRNSQASVLAPTGTIGLAMDCDTTGIEPDLALVKFKKLVGGGSMQIVNRTVPRALRTLGYPEEQVEAIVEYISEHGSVVGAPGLRPEHYEVFDCAMGDRAISPMGHVRMMAAVQPFISGAISKTVNMPESATVEDVEEIYFQGWKLGLKALAIYRNNCKVGQPLSDAKEKKVSAAVEGSHEHRPVRRRLPKRRPSQTISFSVGGAEGYLTAGSYPDNGLGEVFLKLGKQGSTLAGVMDAFAIAISIALQYGVPLEAFVSKFVNMRFEPSGMTDDPDIRFASSIMDYIFRRLALDYLPYEKREELGIFSAEERARKQSGELSAASAEPLADETADSVTADDAEARADTAVAGSAPRATTPGLGGHGAAELVDRVFGQAADAPLCMNCGTTMRPAGSCYVCEGCGSTSGCS
>NC_008578.1|WP_011720312.1|1658917_1659430_-|transcriptional-repressor-NrdR
MYCPFCRHPDSRVVDSRVTDDGTAIRRRRSCPECGRRFTTVETAALSVIKRSGVIEPFSRAKVIAGVRKACQGRPVSEDALALLAQRVEDELRATGCSEVTSQEVGLAVLGPLRELDDVAYLRFASVYRGFESLEDFEAEIALQRAERALERSETVERGRPVPSRGVDDR
>NC_008578.1|WP_011720313.1|1659727_1660042_-|LysM-peptidoglycan-binding-domain-containing-protein
MASTVRLTRRGRRVLTAGAMVLIALLTLVITVLLTRLAHAAPPAPSADDRQVHRVLVVQPGDTLWQIALRLAPQTDPRVTIARILAVNPSARAVIQPGQQLVVP
>NC_008578.1|WP_011720314.1|1660254_1661082_+|transcriptional-repressor-LexA
MKRSTPRPARSQAALTTSSEESPDRVERGGDGVATVTDFPDGPPDETGLTPRQRRILDVIRDSVRRRGYPPSMREIGEAVGLTSTSSVAHQLMVLQRKGFLRRDPNRPRAVEIRSAESAVPDASAGHSPAADRAPSARRPPRGPSPIDSNPDVVAVPLVGRIAAGGPALAEQLIEDVVPLPRQLVGEGTLFLLQVKGDSMVDAAICDGDWVVVRQQPVAENGDIVAAMIDGEATVKTFKRRGAHIWLMPHNPQYEPIPGDEATILGRVVAVLRRL
>NC_008578.1|WP_148204679.1|1661159_1662839_-|ATP-dependent-DNA-helicase
MDALPMDVARAGAAPAREKTGGAGVIAAGLPGTANVRQGTGESPDAPAAGFLAWSALGREVARITSWANETSTGDRDELVPGVSERAWGQFAVTARECVGASRCPHGSRCFSELARIRAGQADIVVTNHAMLAVDVLGDAPVLPEHDVVIVDEAHELVDRVTAAATAELGAADVVRVANRLRTFASVAAGRLERAVGEFDAALRDVSVGRLIDLPERLVTVLSGIRDAAREGVSALLGEITVDGRRAQARAAAEELFDTASRFLAGDSGDVRWLDRDDRGGAVLRAAPLDVAPLLRNAIFASRIAVLTSATLTVGGSFHPMIERLGLHHDVRTLDVGSPFSYQRQGILYVASHLPPPGRDGISADALEELVALMTAAGGRTLGLFSSMRAAQEAAAFARERVDFPVLCQGDDATAELIRRFAADAQTCLFGTLSLWQGVDVPGAACQLVVVDRIPFPRPDDPLMAARQQAVTEAGGNGFLQVAAGHAALLLAQGCGRLLRSPHDRGVVAVLDSRLATARYARFLRSSLPPFWYTTDRDLVCRSLRALSARSGSASSSAS
>NC_008578.1|WP_169303200.1|1663288_1666096_-|EAL-domain-containing-protein
MPPADNFEVGRGGRFEHALLGALAAALGAAATGAGLGFVAPVLGNALVGAGGTVAGVAAGAGFVVRARADAVRRFGWLAVGVFAVAGTAWSTVAAVQVAVPGRAPVLAAHPNGDLGALVAAPFGVLGLLVLTRRDGNRQSRLLAGLDAAIAACALATLAYGVGRPAGVGAVGTLHAIAAVLLGTAAIAAIARCRLEGDIPFLALFLIGAGVIVCELGDLFSLRPLALGEWSPRHPSYLLAVAGRLVLGLAVLSRTAERADLVQLRRREYIAVLTPVLPVLAVGSLLIAAAVMRVSLRPATLILLGVLGILLLLAWLAARLDQLLLSRTLEHRVVERTLALRTHAKWFRSLVQNSSDIITIVDPSGVIRYQTPSATRVLGYDPNAMVGQRFVSLVAPADVHRLEAILLDAVLRPRSTHTIEFAMRHAAGHWRETETVITSLVDDHDIRGLVLNTRDVSERKELERQLTRQAFSDPLTGLANRALFANRVEHALSERSRQPGEVAVLFLDLDGFKGVNDAQGHAVGDHLLTLVADRLRRCVRPSDTVARLGGDEFAILVVGPQAEAHGVDVAERVQRALAEPFLLSGREVTLAASIGIAVTDDGTETVDQLLRNADLAMYRAKSSRKGTYVRFRTEMHDALLARVQTETDLRHALSRRELVLHYQPTVNLRTGQVVGVEALIRWYHPTRGLIQPMDFIGMAEETGLVESIGAWAIRECCRQGARWQRYAQPGGVFHVAVNVSGRQLHPRLPDIVRTALTETGMPPGALVIEVTENILVKRSEEAIAVLRQLKSFGVRVAIDDFGTGYSSLSYLARFPVDVLKIDKSFVEQITDRNSGTEGTELVRTILHLGRALRLGTVAEGIETREQYAALLAMSCDYGQGYLFSRPLPAEGIDTLFGGTLVAGLPEQRVVYDATTHLSASRETGRWSVGPARLRA
>NC_008578.1|WP_148204680.1|1666311_1667823_-|GTPase-HflX
MTDTPAPDLSARDPQPSARGVRDMRPSTLSARDAQPSGLSAADDENLDVADRHALRRVPGLSTELRDVTEVEYRRLRLERVVLVGVWTHGTMRDAENSLVELKLLAETAGSQVLAGLLQRRDKPDPATYIGAGKARELRDIVVTSGADTVICDGELSPSQLRNLEQLVKVKVVDRTALILDIFAQHARSREGKAQVELAQMTYLLPRLRGWGESLSRQAGGRAGAGGVGIGGRGPGETKIELDRRRIRARMTKLRRELAELATTRDVKRRKRRVNDIPAVAIAGYTNAGKSSLLNRLTGAGVLVEDALFATLDPTVRRATTSDGRIYTLTDTVGFVRHLPHQLVEAFRSTLEEVTDADLVLHVVDGAHADPFGQIDAVRAVFDEIGASHIPELVAVNKTDIADPAVVATVLRAEERKGNRAVAVSVRTGAGLDDLRRAIEEMLPRPAVHVDVLVPYDEGRWVARIYELGDVDAVEHTPAGTRVRARVPAALAAELAHLGSPSR
>NC_008578.1|WP_083760544.1|1667885_1668881_-|diaminopimelate-epimerase
MVPARSADPLARRGRRRSRNSRRPYDRRVDDVPFLKGHATRNDFVILPDHDDELELDAALVRAICDRRRGLGADGILRVVAVPADDAPVSSAGATADAAAGRPPQPSAGRPPQPAAARWFMDYRNADGSVAEICGNGIRLFARYLVDAGLEEAGRFLVGTRIGPVPVDVPPAGDVTAWLPAPELRGGGRARFDGRMLEGVRVSVGNPHLVCVVDTLADVDFTRAPVLDSDEFPDGANVEVVEIERPGVLRMRVYERGVGETWSCGSGACAVAAVAEGAERIPRPADGWWRIVVPGGELRIRFDGDRVALAGPAVVVAEGRLHLAALEKSDG
>NC_008578.1|WP_041835600.1|1668775_1669714_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MSSSASLQRVVVLVGPTATGKSVLAVRLAQRFNAEVVNADSMQVYRGMDIGTAKLPPAERDGVAHHVLDVWPVTKTASVAEYQHLARAAIEEIGRRGRLPILVGGSGLYVRAAVDRLEFPGTDPAIRARLEAELAAHGPEALHARLARLDPQAAERILPTNGRRIVRALEVLQLGRPRFAAELPEYASVYDALFLGLDLATPELDDRVERRVAAMWQAGFVDEVRHLAEDCGLREGRTASRALGYRQVLTMLDGGCDEAEARRRTVDATKRFVRRQRSWFRPDPRIHWLDAADAALETAAARTIEGWMTSRS

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Crispr_ID: NC_008578_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_10

1681826-1681929

Orphan

Consensus_repeat	Method
GAAATACGGCCATATGCGGGCCGCTCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_10

>merge|NC_008578|10|1681826-1681929|CRISPRCasFinder
GAAATACGGCCATATGCGGGCCGCTCGGCCAGCGGCTCGGCGTCGATCCCGCGGAGGTGGCCGACGACATCGTGCGAAATACGGCCATATGCGGGCGGCTCGGC

>NC_008578|10|10|1681826-1681929|CRISPRCasFinder
GAAATACGGCCATATGCGGGCCGCTCGGC	CAGCGGCTCGGCGTCGATCCCGCGGAGGTGGCCGACGACATCGTGC
GAAATACGGCCATATGCGGGCGGCTCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_011720328.1\|1681249_1681444_-\|DUF3046-domain-containing-protein	unknown	unknown	gnl\|CDD\|378612
NC_008578.1\|WP_011720338.1\|1697684_1698611_-\|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl\|CDD\|235107
NC_008578.1\|WP_011720332.1\|1689034_1690318_-\|competence/damage-inducible-protein-A	unknown	unknown	gnl\|CDD\|234789
NC_008578.1\|WP_011720334.1\|1690998_1692426_-\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl\|CDD\|272900
NC_008578.1\|WP_011720333.1\|1690336_1690999_-\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|273139
NC_008578.1\|WP_011720337.1\|1696002_1697688_-\|ribonuclease-J	unknown	unknown	gnl\|CDD\|223668
NC_008578.1\|WP_011720329.1\|1682082_1682712_+\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NC_008578.1\|WP_011720326.1\|1679293_1679677_-\|regulatory-protein-RecX	unknown	unknown	gnl\|CDD\|234646
NC_008578.1\|WP_011720335.1\|1692451_1693273_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224343
NC_008578.1\|WP_011720330.1\|1682708_1684055_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_148204569.1\|1693462_1695859_-\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|224588
NC_008578.1\|WP_041835602.1\|1673945_1675397_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237674
NC_008578.1\|WP_083760641.1\|1688468_1688909_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_008578.1\|WP_041835008.1\|1670741_1671944_+\|DUF349-domain-containing-protein	unknown	unknown	gnl\|CDD\|377186
NC_008578.1\|WP_011720327.1\|1679841_1680879_-\|recombinase-RecA	unknown	unknown	gnl\|CDD\|236476
NC_008578.1\|WP_011720320.1\|1669748_1670552_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153388
NC_008578.1\|WP_011720325.1\|1677505_1678981_-\|ribonuclease-Y	unknown	unknown	gnl\|CDD\|237177
NC_008578.1\|WP_083760545.1\|1672145_1673864_+\|cell-wall-binding-repeat-containing-protein	unknown	unknown	gnl\|CDD\|367829
NC_008578.1\|WP_011720324.1\|1675568_1677509_+\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NC_008578.1\|WP_041835600.1\|1668775_1669714_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_011720328.1\|1681249_1681444_-\|DUF3046-domain-containing-protein	gnl\|CDD\|378612	pfam11248, DUF3046, Protein of unknown function (DUF3046). This family of proteins with unknown function appears to be restricted to Actinobacteria.	5.42831e-28
NC_008578.1\|WP_011720338.1\|1697684_1698611_-\|4-hydroxy-tetrahydrodipicolinate-synthase	gnl\|CDD\|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	8.03985e-153
NC_008578.1\|WP_011720332.1\|1689034_1690318_-\|competence/damage-inducible-protein-A	gnl\|CDD\|234789	PRK00549, PRK00549, competence damage-inducible protein A; Provisional.	4.43525e-155
NC_008578.1\|WP_011720333.1\|1690336_1690999_-\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl\|CDD\|273139	TIGR00560, pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis].	6.48995e-31
NC_008578.1\|WP_011720337.1\|1696002_1697688_-\|ribonuclease-J	gnl\|CDD\|223668	COG0595, COG0595, mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair].	0
NC_008578.1\|WP_011720329.1\|1682082_1682712_+\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	5.26178e-46
NC_008578.1\|WP_011720326.1\|1679293_1679677_-\|regulatory-protein-RecX	gnl\|CDD\|234646	PRK00117, recX, recombination regulator RecX; Reviewed.	1.8748e-20
NC_008578.1\|WP_011720335.1\|1692451_1693273_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224343	COG1426, COG1426, Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown].	1.47699e-21
NC_008578.1\|WP_011720334.1\|1690998_1692426_-\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	gnl\|CDD\|272900	TIGR00089, Ribosomal_protein_S12_methylthiotransferase_RimO, radical SAM methylthiotransferase, MiaB/RimO family. This subfamily contains the tRNA-i(6)A37 modification enzyme, MiaB (TIGR01574). The phylogenetic tree indicates 4 distinct clades, one of which corresponds to MiaB. The other three clades are modelled by hypothetical equivalogs (TIGR01125, TIGR01579 and TIGR01578). Together, the four models hit every sequence hit by the subfamily model without any overlap between them. This subfamily is aparrently a part of a larger superfamily of enzymes utilizing both a 4Fe4S cluster and S-adenosyl methionine (SAM) to initiate radical reactions. MiaB acts on a particular isoprenylated Adenine base of certain tRNAs causing thiolation at an aromatic carbon, and probably also transferring a methyl grouyp from SAM to the thiol. The particular substrate of the three other clades is unknown but may be very closely related.	2.03948e-119
NC_008578.1\|WP_148204569.1\|1693462_1695859_-\|DNA-translocase-FtsK	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	1.90923e-157
NC_008578.1\|WP_041835602.1\|1673945_1675397_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237674	PRK14326, PRK14326, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
NC_008578.1\|WP_083760641.1\|1688468_1688909_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.15427e-08
NC_008578.1\|WP_041835008.1\|1670741_1671944_+\|DUF349-domain-containing-protein	gnl\|CDD\|377186	pfam03993, DUF349, Domain of Unknown Function (DUF349). This domain is found singly or as up to five tandem repeats in a small set of bacterial proteins. There are two or three alpha-helices, and possibly a beta-strand.	5.87893e-16
NC_008578.1\|WP_011720327.1\|1679841_1680879_-\|recombinase-RecA	gnl\|CDD\|236476	PRK09354, recA, recombinase A; Provisional.	0
NC_008578.1\|WP_011720320.1\|1669748_1670552_-\|hypothetical-protein	gnl\|CDD\|153388	cd07951, ED_3B_N_AMMECR1, The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain. This subfamily is composed of uncharacterized proteins containing an N-terminal domain with similarity to the catalytic B subunit of class III extradiol dioxygenases and a C-terminal AMMECR1-like domain. This model represents the N-terminal domain. Class III extradiol dioxygenases use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon, however, proteins in this subfamily do not contain a potential metal binding site and may not exhibit class III extradiol dioxygenase-like activity. The AMMECR1 protein was proposed to be a regulatory factor that is potentially involved in the development of AMME contiguous gene deletion syndrome.	1.24326e-18
NC_008578.1\|WP_011720325.1\|1677505_1678981_-\|ribonuclease-Y	gnl\|CDD\|237177	PRK12704, PRK12704, phosphodiesterase; Provisional.	0
NC_008578.1\|WP_083760545.1\|1672145_1673864_+\|cell-wall-binding-repeat-containing-protein	gnl\|CDD\|367829	pfam04122, CW_binding_2, Putative cell wall binding repeat 2. This repeat is found in multiple tandem copies in proteins including amidase enhancers and adhesins.	2.30908e-16
NC_008578.1\|WP_011720324.1\|1675568_1677509_+\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	1.80489e-66
NC_008578.1\|WP_041835600.1\|1668775_1669714_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	1.6745e-136

>NC_008578.1|WP_011720328.1|1681249_1681444_-|DUF3046-domain-containing-protein
MRLTDFWDRMRSAFGEVYAASFAHDFVLAELGERTVHQALEAGVEPADIWRAVCRAVDVPTHLQ
>NC_008578.1|WP_011720327.1|1679841_1680879_-|recombinase-RecA
MAAAFDREKALEHAIAQIERAHGKGSLMRLGDEARAPIDVIPTGSIALDVALGIGGLPRGRIVEIYGPESSGKTTLALHAVANAQRAGGIAAFIDAEHALDPEYAKKLGVDTDNLLVSQPDTGEQALEIADTLIRSGAIDVVVIDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKITGALSHSGTTAIFINQLREKVGVFFGSPETTTGGKALKFYASIRLDVRRIDTIKEGQEAIGNRTRVKVVKNKCASPFRQAEFDILYNVGISREGSLIDMGVEHGIIRKSGAWYTYEGDQLGQGKENARNFLRENPDLADEIEKKIKEKLGIGPRVDAPIDLTVVER
>NC_008578.1|WP_011720326.1|1679293_1679677_-|regulatory-protein-RecX
MLERLAAVGLIDDRAYAVQWMTSRRRRGLAPRAIAGELRRRGVDEVIIRETVDTVDPDDVLAAATALARMRCRTMVGLPEPVKVRRLAAMLARRGYSPEVVFQAIRHVLGDGVIEEGATDASDAERA
>NC_008578.1|WP_011720325.1|1677505_1678981_-|ribonuclease-Y
MPVLIATVGVVAVAALVIAIFVVIKFGRAPRVDAGNVRQPSGMSGPDAAAAEAEIREARSELERREQRLAEREARLDAEHERLAARERQLAELEEKLGRLQAELAQVAEERRLLLERTAGLTAEAAKAELVALIENQAKRDAALTVREIERAATEEAERRAREIVTTAIQRVASEQTAESVVSVVHLPGDEMKGRIIGREGRNIRAFESITGVNLIIDDTPEAVLLSCFDPVRREIARVALERLVDDGRIHPLRIEEVYEASRLEVERLCQRAAEDALLAVGITGMHPELVALLGRLRYRTSYGQNVLKHLVETAHLAGVMAAELHIDPQLVKRGALLHDIGKALSHEVEGSHALIGAELARRYGEHEDVVHAIEAHHNEVEPRTIEAVLTQAADAISGGRPGARRESLESYVQRLERLEEIASAYEGVEKVFAMQAGRELRVMVLPDVVDDIQAQVIARDIAKQIETELTYPGQIRVTVVRETRASEFAH
>NC_008578.1|WP_011720324.1|1675568_1677509_+|S9-family-peptidase
MPEIAPYGSWVSPISAADVARGGVRLGFPSLVAGDVWWLEGRPTEQGRQVVVSAQRGDLLGPPWNARTRVHEYGGRSFWPIAADSFVFSEWTDQRLYLVTGEEDPRPLTPAPAVPSGWRYADATVGPDGQVWCVRETVTAAGALDVVRDIVAVPLDGSAADDPRRIRVVVGGSRFFAYPTVSPDGGRLAWVAWDHPQMPWDGTELRIGALRDGIVDTWTTVAGGPAESILQPTWATDGSLYFLSDRSGWWNLYRWDGAAVHALAPRDEECGGPLWQLGMRWFAPLADGRIAVIHGGHLGVLNPDSGEVVDVAIPLSYVDASVTADGSEVVVVGASPTHPLSVARVDVSTGRYAVVRRSLETLPPEEYLPVPVTRIFRSDDGHDVHAHVYPPRNPDFRAPDGERPPYIVVAHGGPTASSPPIFRLEYAYFTNRGIGILDVDYGGSSGYGRAYRERLRGQWGVVDVADCVTAVRALAASGEADPNRVAIRGGSAGGWTVLCAVTRTDVFAAGTSYFGVADPEQLAAETHDFESHYLDGLLGPLPEARDVYRERAPIRRVDAVRCPVLLLQGAQDPIVPPSQAELFRDALAAKGIPHAYLLFEGEQHGFRQAENIVRALEAELSFYGQLFGFSPPGIPVLPLTPAPPAP
>NC_008578.1|WP_041835602.1|1673945_1675397_-|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MPAAGPAPDRPRTYQVRTFGCQMNMHDSERIAGLLEAAGYVRAADDEPADVVVFNTCAVRENADNRLYGNLGLLLPVKKAKPDMQIAVGGCLAQKDKGDIVRRAPWVDVVFGTHNIEALPVLLERARIAREAQVEIREALEVFPSTLPSRRESVYAAWVAISVGCNNTCTFCIVPSLRGRERDRRPGDILREIQTLVADGVLEVTLLGQNVNSYGVDFGDRQAFAKLLRACGTIDGLERVRFTSPHPRDFTDDVIAAMAETPNVMPQLHMPLQSGSDAVLRRMRRSYRKEKYLDIISRVRSAIPDAAITTDIIVGFPGETEDDFAETLDVVRKARFAGAFTFQYSKRPGTPAAEMPDQVPPDVVADRFARLVALVEQIALEENQAQVGRVVEVLVAEGEGRKDAETHRMSGRAPDNRLVHFRATDARPGDVVTVAVTQAAPHCLIADQVLGVRRTRAGDAWEARRSVRPSGVLLGMPALRPRT
>NC_008578.1|WP_083760545.1|1672145_1673864_+|cell-wall-binding-repeat-containing-protein
MRGGATTRCVHTEAGQRRRAPMRPARVLAGAVLALSAIAGVPSSGTAAASPAGHRSPTAVPAPIRLHALPATTGTVQRLAGPDRYATSAAVLGTYPTGVSRLFVATGATYPDALAAAGAAGAQDAVLLVGNPPSQTTINAVAANHPGQIILVGGPAAIPDTTGDLLGRYAANGWSRIAGADRYATAALLATATWTSAPTVYLASGESFADALTAAALAAARNSPVLLTAPDAVPAPTQAALAQLHPSSVVIVGGTAAISDTVASEISQAIAPVTRIAGADRYATNALAVGSFGGSVANLVVASGATFPDAISGAALAGHLQTALLLVGSSLTNAQQSLVATLHPAAVTVVGGAAAISDAVVDAVAVAAGLSPPVNAADNDYVVNTIAGQVVRWNPCQPVGWQLNIGSLPSSVASVISTEVQVLAADSGLTLRYDGTTTFVPTTTNIDTEPDDLIVAVIPRSATDLFDGATGTVVGEGGWTAGYNANGHIVIAHGFAVITQDALATGLLPISTQGGVTLGTAVLHELGHAVGLNHASQPTEIMYPVLSPQTPATYSPSDRAGLAAVGAPAGCL
>NC_008578.1|WP_041835008.1|1670741_1671944_+|DUF349-domain-containing-protein
MGIETQWGRIAPDGTVYVKTRDGERVVGSWQAGSLEDGLAHFVRRYEDLATEVGLLETRFASGTASPSTTLVAAKRLRESLPTANVVGDLDALDSRLSQLIDAAAAKREEEREARRLAAHQATEAKRALVEQAEELAQSTQWKKAGDRLREIADQWREIKGADRKAEAELWKRFAAARSEFNRRRGEYFSRLEQERKDIIARKEKLIAEAESLAQSSDWTTAGNRFRTLMTEWKNAGHVNRDTESALWQRFRAAQETFYSRRAEALAQRDEEQRANQAAREALLAEAETVDVNGDPDALQTKLRDLQRRWAQIGRAPRDVSADLDKRFDTLVARIRNAIDEQRRAAAVSSSPLVIRLRESVAKLERKIDRARQAGRTAEVDQLEAQLATQREWLARTLHH
>NC_008578.1|WP_011720320.1|1669748_1670552_-|hypothetical-protein
MITDGEFDALVRGELRPAAVAFCPHPPVLIPAIARKAAAEFAPLLAACDDAVQWLTERATVVGIVGSRVPTAPVSHFAPGVAAQELPPDDLPLSVAIGWWLIDRMAPAHDRFAVAVDPDGGRAALLRSEVQATEGPVGLLVMGDGSARRGPKAPGYVDPRAEPFDAAVSAALAAADRTTLANLDVAAATELLVAGVGPWRAVARWTAEGEWTASVRYADASAGVQYIVATWARSDPAGAAAVSHGIAATVGKFPGPALHVVAGPASS
>NC_008578.1|WP_041835600.1|1668775_1669714_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MSSSASLQRVVVLVGPTATGKSVLAVRLAQRFNAEVVNADSMQVYRGMDIGTAKLPPAERDGVAHHVLDVWPVTKTASVAEYQHLARAAIEEIGRRGRLPILVGGSGLYVRAAVDRLEFPGTDPAIRARLEAELAAHGPEALHARLARLDPQAAERILPTNGRRIVRALEVLQLGRPRFAAELPEYASVYDALFLGLDLATPELDDRVERRVAAMWQAGFVDEVRHLAEDCGLREGRTASRALGYRQVLTMLDGGCDEAEARRRTVDATKRFVRRQRSWFRPDPRIHWLDAADAALETAAARTIEGWMTSRS
>NC_008578.1|WP_011720329.1|1682082_1682712_+|SigE-family-RNA-polymerase-sigma-factor
MSVLVDATGPLRGASAAADEMPGVSVDDERRRVFDEFARARMPELLRFGYALTGNPHAAADLVQDALERTMLAWHRVEKQGDPEGYVRRIMVNRNISIWRRLRRERLVVDIPEESGPSDGLTPRDLALWERVRALPPRQRTVIVLRYYEDLSEAQIAEIMGSSVGTVKSQASRALAALRRDAAQFADVPGAGGRTDDPRITRSRKGMEP
>NC_008578.1|WP_011720330.1|1682708_1684055_+|hypothetical-protein
MTDDELDERLRALFRAGHPPLVPRPDMLEVIHRGARRRQARRAGTLAAAGVVAVALATTAVVRPFAPARQTAGTHAQTAAAVQPSRLVASPTLQATETSAPAVAATSAEAGTVPAGGTPPAGFVPLSVTGTTSNGQTFWVLGDAPCATGTCTAVAKTTDGGQSFTEMAAPASAVVPDHLLGMDGVSPQTIANMRFVDAKNGWAFGGALWQTTDGAQSWQQITSITGTVQQLEVASGHAWAIVATGGGSPPGATGTARLFTATYPAGTWGPVDAAGVFGPAEPALVVHDTTVIVAGEDPTTGTPRAVRSTDAATFAELPAPPCVPAPTGGLSITASALWLLCADHARAYVSTDAGTSWRQVGSTLPADAAVVAAIDPTTAVIAHGGRLIRIGTDGTMQTAATPSGASGFAFVGFVNDTVGFAIAEVANSRQLWRSTDAGAHWSLVRIGG
>NC_008578.1|WP_083760641.1|1688468_1688909_-|helix-turn-helix-transcriptional-regulator
MILLRRLIGDALRRHRLRQERTLRDVSAEARVSLGYLSEIERGQKEASSELLAAICDALGVHLSDVLREVSDELRVLEAAQMPSYEPDADGRRRERVTRRGGDGASVDDRLTAALTETLVAAANTDAVTHPDDDRPSPSDRLTVPV
>NC_008578.1|WP_011720332.1|1689034_1690318_-|competence/damage-inducible-protein-A
MKAEVVAIGTELLLGDIVNGNAAWLGQALAELGVDVEQMAVVGDNVARIAEVLGAATRRADVVVATGGLGPTQDDLTREALAELAGVPLERDPEIEAALRARYAALGRADFPPMNLRMADRPHGAVPLPNPAGTAPGLRMTVGNAVIFALPGVPGEMREIFRRWVAPELAERAGPGTVLLSRVLRTIGVWESEVADALADLDAELALRGNPTLAYLASEGQTRVRISAKAANRDLAAAMIAEVEERARIALGDAVYGADSDTIEAVVHRLLTDAGATVATAESLTGGLVGAALTETPGASDVYRGGVIGYTVAAKVELLGLAPELIAARGVVDPEVAVVMAESIRSRLGATYGVATTGVAGPARQDGKPVGTVYVAVTAEGGPTVRDVHLSGDRQRIRRQAVNIALDLLRRRLLNLPPEPQLRRRRS
>NC_008578.1|WP_011720333.1|1690336_1690999_-|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MPDPQRRSPSSTPPPVGIANLANGLTTVRLLLVPVFAVLLAFGADGTAHPQWRYAATGVFVIASLTDRVDGEIARRRALITTFGKIADPIADKALIGAALIGLSAIGALPWWVTAVILGREFGVTALRFWVIRNGVAAASSGGVLAASQAAKAKTVAQAVAIGLYLLPVSGVWGTARFWVMMIAVAITVVTGVNYLYRAIRVRRRQRSEAAAVRATIAQS
>NC_008578.1|WP_011720334.1|1690998_1692426_-|30S-ribosomal-protein-S12-methylthiotransferase-RimO
MPASRTVRLIRLGCARNDVDAEELAARLVDAGWRLTEAPSADVTVVNTCGFIEAAKQESIDTLLEAADGSTRVVAVGCLAERYGAALADAMPEATILSFDDYPVIAQRLEDVLAGRPPAPHTPRDRRTLLPLTPVDRPRAAAEVGIPGHLGGPRVLRHRLDDSPVAPLKIASGCDRRCTFCAIPSFRGAFVSRPPADILREAQWLADHGAREIVLVSENSTSYGKDLGDPFALEKLLAAFGGVDGLVRVRVTYLQPAEVRPALIDVIATAPHVAPYFDLSFQHASPRVLRRMRRFGGSEEFLNLLAEIRRRNPRAAVRSNVIVGFPGETEEDVAELGEFLRAARLDGIGVFGYSDEDGTEASGFPEKIPEQEIRSRVDDIAGIAEEVTADRARARLGETVDVLIDGVDDDRPDACYGYTEVQAVDVDGVTVLRDCSAARGALVRAEIVEIDGVDFLAAPVTGSTAGTPSGATVEG
>NC_008578.1|WP_011720335.1|1692451_1693273_-|helix-turn-helix-domain-containing-protein
MSIGQSLAEARERAGLSIEDVAARTRLRASVIRAMENDDFSLCGGHFYARAHLRTLAGVVGIDPAPLLAEYDARYGRNEDDDVTAKLAEVETASKLIARTQELRRTSWGSLALAALLVVIIVAVGAQLLTSHGRTPSRASGPVGAPSSASGPSPSAAATPSISAVPSSGSPSPPPTGAPSSAVAEAGVKVVVRVTTAKCWVLARASDGTTLYQGIMNPGDVQTFTDPQQIYLKLGNAPATDLVVNGVEIGAPPSTNDVAAFTFGPGPPNVGQG
>NC_008578.1|WP_148204569.1|1693462_1695859_-|DNA-translocase-FtsK
MPPALRVILRLIRALWLGLAHLVGGAVRLIGHRARDLDPTHRRDGFGLAVLGLAIVTGGALWWRLPNPVGAVTVAIVAGAVGAASYAVPVGLAALAWRILRHPQRPVGEGRLLVGWVALGVGVLGLLHIAAGTPDPSHGAHAMRTAGGLIGFLVAAPLVAGLSSWIAVPLLVLVALFGVLVVTATPVNAIPRRIAELRDRLRRRTAVPAANPPAPAGAAARPRRARRPTTTDDADDTAESRPFDTPLVGGSSGSAPEPGTVEPGGRPSTADPAVPAGVEGHSTTSAAADGSSAARRDKPWPRAEQLLLSGDITYHLPPPTLLREGTPAKPRTRANETVVAALTDVLQQFGIDATVTGFTRGPTVTRYEVELGPGVKVERVTALSKNIAYAVASADVRILSPIPGKSAIGIEIPNADRDLVSLGDVLRSPAATSDHHPMVVGLGKDVEGRYICANLAKMPHLLVAGATGSGKSTCINTIVTSILTRATPDEVRMVLVDPKRVELSHYDGIPHLVAPIITSPKKAAEALQWVVREMEMRYDDLAASGFRHIDDFNRAVRKGQLRPPPGSERVYRPYPYLLVIVDELADLMMVAPRDVEDAIVRITQLARAAGIHLVLATQRPSVDVVTGLIKANVPSRLAFATSSLADSRVILDQPGAEKLVGLGDALFLPMGASKPLRLQGAFVTESEVQAVVAHCKQQMQPTYRDDLLAESPARRALDDDIGDDLDLLCQAVELVVTTQFGSTSMLQRKLRVGFAKAGRLMDLMETRGIVGPSEGSKARDVLVKPDDLPSILATLRGN
>NC_008578.1|WP_011720337.1|1696002_1697688_-|ribonuclease-J
MSHPHPELGAPPPLPPHGLRIVALGGLGEVGRNMTVFEFGGRLLIVDCGVLFPDPEQPGVDLILPDFDYIRGRLDAVEALVLTHGHEDHTGAVPFLLRERPDIPLVGSPLTLAFAESKLAEHRITPYTLTVREGSRERLGPFDCEFFAVNHSIPDGLAVAIRTPAGLVLHTGDFKMDQLPLDGRLTDLGGFARLGAEGVDLLMSDSTNAEIPGFVTPERDIAPVLRDIFSRAGRRIIVACFASHVHRVQQVLDAAAAFGRKVAFVGRSMVRNMGVARDLGYLQVPGDLLVDAREIDALPPEKVVLISTGSQGEPLSALSRMANRDHPVRIEPGDTVVLASSLIPGNESAVYRVINGLGRWGATVIHKGNALVHVSGHAPAGELLYVLNLTRPSNFVPIHGEWRHLRAHGELAKLTGVPADRVLLAENGMVMDLVDGKASIVGAVHCGYVYVDGISVGEVTEASLKDRRILGEEGFVSVVVVVDAAAGKVVGGPEIHARGSGIDDAALVDVLPKVHESVERAMADGMADIAELEQVVRRTVGRWVNETYRRRPMIIPMVVEV
>NC_008578.1|WP_011720338.1|1697684_1698611_-|4-hydroxy-tetrahydrodipicolinate-synthase
MTTSLRPAPFGRVLTAMVTPFTADGALDLDGAARLATYLVDHGNDGLVISGTTGESPTTTDDEKERLLRAVLDAVGDRATVVAGVGTNDTRHTIELAQRAEKAGAHGLLVVTPYYSKPPQAGLLAHFRQVADATGLPVMLYDIPGRTGTAIEPETMVRLAEHERIVAVKDAKGDFEASSWVLARTDLAYYSGDDKNTLPLLAIGAVGVVGVPTHVFGTQTGAMIAAYLRGDVDGALALHRQLLPVFTGFFRTQGVILAKAALRLAGLPGGPVRPPLVDATAEQVARLREDMAAAGFTEFAEGAEERRG

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Crispr_ID: NC_008578_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_11

1869424-1869520

Orphan

Consensus_repeat	Method
GCGTCATCCGCCGCCATGGCCACAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_11

>merge|NC_008578|11|1869424-1869520|CRISPRCasFinder
GCGTCATCCGCCGCCATGGCCACACCCTATCCACCCCGGCGACGAAGCGACCGGCCGGATTCTGCCGCACCAGCGTCATCCGCCGCCATGGCCACAC

>NC_008578|11|11|1869424-1869520|CRISPRCasFinder
GCGTCATCCGCCGCCATGGCCACAC	CCTATCCACCCCGGCGACGAAGCGACCGGCCGGATTCTGCCGCACCA
GCGTCATCCGCCGCCATGGCCACAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_011720497.1\|1870218_1871571_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|227334
NC_008578.1\|WP_011720500.1\|1874429_1875068_+\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|376498
NC_008578.1\|WP_011720485.1\|1856159_1856441_+\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197385
NC_008578.1\|WP_083760554.1\|1862061_1863753_+\|MmgE/PrpD-family-protein	unknown	unknown	gnl\|CDD\|377179
NC_008578.1\|WP_011720489.1\|1859957_1860995_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NC_008578.1\|WP_011720493.1\|1864659_1865781_+\|bifunctional-2-methylcitrate-synthase/citrate-synthase	unknown	unknown	gnl\|CDD\|237590
NC_008578.1\|WP_041835042.1\|1877758_1877998_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720505.1\|1878388_1879972_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|240135
NC_008578.1\|WP_011720494.1\|1866240_1868934_+\|glycoside-hydrolase-family-3-protein	unknown	unknown	gnl\|CDD\|224389
NC_008578.1\|WP_041835040.1\|1873705_1874368_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225222
NC_008578.1\|WP_041835039.1\|1871752_1873699_+\|S8/S53-family-peptidase	unknown	unknown	gnl\|CDD\|173788
NC_008578.1\|WP_049751637.1\|1859526_1859781_+\|SHOCT-domain-containing-protein	unknown	unknown	gnl\|CDD\|225993
NC_008578.1\|WP_011720507.1\|1880800_1881340_+\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|239474
NC_008578.1\|WP_011720496.1\|1869577_1870222_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_148204689.1\|1856507_1856714_+\|cation-transporter	unknown	unknown	gnl\|CDD\|225328
NC_008578.1\|WP_049751462.1\|1863734_1864670_+\|methylisocitrate-lyase	unknown	unknown	gnl\|CDD\|131370
NC_008578.1\|WP_011720490.1\|1861043_1861238_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720487.1\|1856773_1859161_+\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NC_008578.1\|WP_148204582.1\|1877156_1877684_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_041835043.1\|1880043_1880652_-\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|376871

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_011720497.1\|1870218_1871571_+\|EAL-domain-containing-protein	gnl\|CDD\|227334	COG5001, COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms].	4.18652e-100
NC_008578.1\|WP_011720485.1\|1856159_1856441_+\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|197385	cd10148, CsoR-like_DUF156, Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156. This superfamily includes various transcriptional regulators that respond to stressors including Cu(I), Ni(I), sulfite, and formaldehyde. It includes CsoR (copper-sensitive operon repressor) from Mycobacterium tuberculosis (MtCsoR), Bacillus subtilis (BsCsoR), Thermus thermophilus (TthCsoR), and Staphylococcus aureus (SaCsoR), Mycobacterium tuberculosis RicR (regulated in copper repressor, MtRicR), Escherichia coli RncR (formally known as YohL, nickel and cobalt-sensitive), Alcaligenes xylosoxidans NreA (nickel-sensitive), E. coli FrmR (formally known as YaiN, formaldehyde sensitive), and Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor, NWMN_0026.5, SaCstR). CsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis. For example, TthCsoR binds the promoter region of the copZ-csoR-copA operon, and represses expression of these genes, which encode the copper chaperone CopZ, CsoR, and the copper efflux P-type ATPase CopA, respectively. In the presence of excess Cu(I), TthCsoR binds this ion, and is released from the DNA, allowing expression of the downstream genes. TthCsoR also senses other metal ions such as Cu(II), Zn(II), Ag(I), Cd(II) and Ni(II). CsoRs form a homotetramer (dimer of dimers). In the case of MtCsoR, two Cys residues on opposite subunits within each dimer, along with a His residue, bind the Cu(I) ion. These residues are conserved in the majority of members of this superfamily. Exceptions include the functionally uncharacterized Bacillus subtilis YrkD where there is an Asn instead of His (C-N-C), E.coli RcnR where there is a Thr instead of the second Cys (C-H-T), or TthCsoR and E.coli FrmR where there is a His instead of the second Cys and which have an additional N-terminal His (not found in those family members having C-H-C) that may also be involved in metal binding (H-C-H-H). A conserved Tyr and a Glu residue facilitate allosteric regulation of DNA binding. SaCstR regulates genes predicted to function in sulfur metabolism; it is thought that oxidation of the intersubunit Cys pair to a mixture of disulphide and trisulphide linkages by sulfite, results in a reduced affinity of SaCstR for the operator DNA. SaCstR exists as a mixture of oligomeric states, including dimers, tetramers and octamers. The sequence of SaCstR was not available at the time this hierarchy was curated and therefore was not included. Escherichia coli RncR represses expression of the gene encoding the nickel and cobalt-efflux protein RcnA. The gene encoding Alcaligenes xylosoxidans NreA is part of the nre nickel resistance locus located on the pTOM9 plasmid from thisbacteria. Escherichia coli FrmR regulates the formaldehyde degradation frmRAB operon.	3.35795e-31
NC_008578.1\|WP_083760554.1\|1862061_1863753_+\|MmgE/PrpD-family-protein	gnl\|CDD\|377179	pfam03972, MmgE_PrpD, MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle.	4.96295e-132
NC_008578.1\|WP_011720489.1\|1859957_1860995_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	5.70491e-33
NC_008578.1\|WP_011720493.1\|1864659_1865781_+\|bifunctional-2-methylcitrate-synthase/citrate-synthase	gnl\|CDD\|237590	PRK14033, PRK14033, bifunctional 2-methylcitrate synthase/citrate synthase.	0
NC_008578.1\|WP_011720505.1\|1878388_1879972_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|240135	cd04865, LigD_Pol_like_2, LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-homologous end joining (NHEJ)-mediated repair of DNA double-strand breaks (DSB). NHEJ-mediated DNA DSB repair is error-prone. It has been suggested that LigD Pol contributes to NHEJ-mediated DNA DSB repair in vivo, by filling in short 5'-overhangs with ribonucleotides; the filled in termini would then be sealed by the associated LigD ligase domain, resulting in short stretches of RNA incorporated into the genomic DNA. The Pol domains of PaeLigD and Mycobacterium tuberculosis (Mt)LigD are stimulated by manganese, are error-prone, and prefer adding rNTPs to dNTPs in vitro; however PaeLigD and MtLigD belong to other subgroups, proteins in this subgroup await functional characterization.	8.11326e-114
NC_008578.1\|WP_011720494.1\|1866240_1868934_+\|glycoside-hydrolase-family-3-protein	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	8.76554e-60
NC_008578.1\|WP_011720500.1\|1874429_1875068_+\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|376498	pfam01227, GTP_cyclohydroI, GTP cyclohydrolase I. This family includes GTP cyclohydrolase enzymes and a family of related bacterial proteins.	3.3685e-88
NC_008578.1\|WP_041835039.1\|1871752_1873699_+\|S8/S53-family-peptidase	gnl\|CDD\|173788	cd04056, Peptidases_S53, Peptidase domain in the S53 family. Members of the peptidases S53 (sedolisin) family include endopeptidases and exopeptidases sedolisin, kumamolysin, and (PSCP) Pepstatin-insensitive Carboxyl Proteinase. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of Asn in subtilisin. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Characterized sedolisins include Kumamolisin, an extracellular calcium-dependent thermostable endopeptidase from Bacillus. The enzyme is synthesized with a 188 amino acid N-terminal preprotein region which is cleaved after the extraction into the extracellular space with low pH. One kumamolysin paralog, kumamolisin-As, is believed to be a collagenase. TPP1 is a serine protease that functions as a tripeptidyl exopeptidase as well as an endopeptidase. Less is known about PSCP from Pseudomonas which is thought to be an aspartic proteinase.	7.71412e-78
NC_008578.1\|WP_049751637.1\|1859526_1859781_+\|SHOCT-domain-containing-protein	gnl\|CDD\|225993	COG3462, COG3462, Predicted membrane protein [Function unknown].	3.6964e-06
NC_008578.1\|WP_011720507.1\|1880800_1881340_+\|carbonic-anhydrase	gnl\|CDD\|239474	cd03379, beta_CA_cladeD, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	3.03414e-48
NC_008578.1\|WP_041835040.1\|1873705_1874368_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	1.34656e-14
NC_008578.1\|WP_148204689.1\|1856507_1856714_+\|cation-transporter	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	6.23541e-15
NC_008578.1\|WP_049751462.1\|1863734_1864670_+\|methylisocitrate-lyase	gnl\|CDD\|131370	TIGR02317, Methylisocitrate_lyase, methylisocitrate lyase. Members of this family are methylisocitrate lyase, also called (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase. This enzyme acts in propionate metabolism. It cleaves a carbon-carbon bond to convert 2-methylisocitrate to pyruvate plus succinate. Some members of this family have been annotated, incorrectly it seems, as the related protein carboxyphosphoenolpyruvate phosphomutase, which is involved in synthesizing the antibiotic bialaphos in Streptomyces hygroscopicus.	6.59811e-135
NC_008578.1\|WP_011720487.1\|1856773_1859161_+\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_008578.1\|WP_041835043.1\|1880043_1880652_-\|biotin-transporter-BioY	gnl\|CDD\|376871	pfam02632, BioY, BioY family. A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin. BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes.	2.44029e-35

>NC_008578.1|WP_011720494.1|1866240_1868934_+|glycoside-hydrolase-family-3-protein
MRRRVRWVLLGTFLLVLLAAAVPAERPHRSTPMAIGRQPAVRVAPSRLVRATTRAVAAAGQRTPDPLARCPWLAAAIRAGAGPDQLAGLVLARMTLTEKIGEIVLRPANGFENTNAGVPRLCIPPLTLQDGPAGLGFGDTGVTQLPAPIALAATFDPSLAWKYGQVQGAEAHAQGIDVVQGPDLNLARVPENGRIFEAYGEDPLLTAAMGTADIQGIQSQGVLAEAKHLVAYNQETDRNLVNVVVSPRALQELYFRPFAAAVTSGHVGAMMCAYPKLNGVYQCEDPALAAQLAAWGFTGLLRTDYAAAPDPVAALKAGVDLVKPADPGALLAAVQSGRLPMAAVNRAVHDILVVAFRYHLVENPPAGRPNTPVASPSHENVALTVAEHAIVLLKNSGGLLPLDAGADAPIAVIGSDAAAPVTGGGGSSAVLPPFVSSPLDAIQARVSNPGDVTFADGATSPAPLPPIPSSALTADSRNTPGLTLTLSDSSSAGRHTVVLPTPVVRIVLGAAPRNRYTITGSTVRTIAIPANAGVTSAVFSGTLTAPTDGLYDFSLSCTGSATMTLDDHVVPLGVLDGEGGTRTAALSLHAGHRYRLAIHWQPFGVTSPAHALYDRAFFALGWKDTTPAIDAAVALAQRARTVVIFAADRTGEGFDRGDLNLPGDQNALISAVADVNPRTIVVLNTAGPVAMPWLSKVGAVVEAWYPGEAAGQAIAAVLFGDIDPSGHLPVTFPTDTAQLGITTAQQWPGTQLTVRYSEGLQVGYRYLNAHQLKPLFPFGYGLSYTTFAMNDMRVAPVAGGYRVTLTITNTGSRAGTATPQLYLTFPAAAGEPPEQLAGFGQVTLAPGESGSVTITVPRNVFSSYWNGRWTTWPGGYRLAAGWSVTDLPIAATVPAPS
>NC_008578.1|WP_011720493.1|1864659_1865781_+|bifunctional-2-methylcitrate-synthase/citrate-synthase
MTSEQSPTVHKGLVGVYADTTAVSTIDEPTNTLIYRGYPAAQLAERYSIEHIAYLLWYGDLPTAAEFDAFTSRIRAAYRLDPAVADWLATTRPDTHPMDLLRTAVSILGATDSSTPQLDRDTTLAQATRLLAQMPAVVAAIQRHRHAQPPIPADPGLGIAENFFHMCFDDIPSEPMVRAFETSLILYAEHGFNASTFTARVVTSTLADLYSAITAAIGALKGPLHGGANEAVMYMLQQIDSPEAAADWVRRALERKERIMGFGHRVYKHGDSRVPAMEKALKTVVAERGATDLLARYHAVQDAVYQAKQLLPNLDFPAGPAYYLMGFDIPIFTPIFAMARVTGWVAHVLEQRADNALIRPLAVYTGPTSRPLP
>NC_008578.1|WP_049751462.1|1863734_1864670_+|methylisocitrate-lyase
MRRHPVTPTSAAADFRAKLTSGRLLRFPGAINPLSAVLIEELRFDGVYVSGAVVAADLALPDIGLTTLTEVVNRAEQIARVTRLPVLVDADTGFGGPVNIARTVQLLTRAGVAGCHIEDQQHPKRCGHLEGKTLVTVTEMLQRIRAAVTARPDPDFVICARTDARTVEGLDAAIDRAKAYVDAGADLIFAEALADEAEIARFRAAVDAPLLINMTEFGRTTLLPASTLATLGVNVVIYPVTLFRVAMGAVERALATIAAEGTQMSLLEGMQTRQRLYELVRYRDYAAFDADIYTFTTPTTTPTAESDSDDQ
>NC_008578.1|WP_083760554.1|1862061_1863753_+|MmgE/PrpD-family-protein
MTVTAVTDGPPTKQHPAVIRHPTRPWCCGKRCSAVPWCDTVRYVADRAGVTPDDTAALAARRDGVWEFRTRVLRPGERADRERELAWQLALLAADNVPLDDNVTAMLINRVIDNTGVAIAALARRPVVNAAAQAARRPATPGASVFGAPTLRSAPEWAAWANGVAVRELDFHDTFLAAEYAHPADNIPPLLAVAQHCGRSGLDVLRALATAYEVHVDLAKGISLHEHGIDHITHLAASVAAGLGTLLALPPDVTYQGIQQAVHTTTTTRQSRKGTISSWKAYAPAFAGMMGILAVDRAMRGETAPSPIYEGTGGVIATLLGGPEAEYVVPLPSPGEPKRAILETYTKEYSAEYHAQAWIDLARRLRDRIPDQSAIRRVVIKTSSHTHRVIGTGSGDPEKYDPDASRETLDHSLMYIFAVALQDGTWHHERSYAPERAHRADTIQLWRSIQTVEDPVWTARYHDTDPAKRAFGGDVLIELADGTTIHDSIDVADAHPRGARPFDRARYIEKFRTLATPFVSDADQETFLRAAENLAELPAGRLAELFPTVTNVPAVPPVSGGIL
>NC_008578.1|WP_011720490.1|1861043_1861238_+|hypothetical-protein
MNREATAHVPTPEHPLLTALSRGLPMTLLVDLVDPNGPRSREVYEREGTGDGLRLAAARFAVTA
>NC_008578.1|WP_011720489.1|1859957_1860995_+|YihY/virulence-factor-BrkB-family-protein
MNIIERGLRRIDRLQQRHALLGVPFATVRKFGDDQAGTQAVLLAYYGFFALFPLLLLLTTILGWLLPGHPGLQNRILNSALANFPIIGTQLRGDVHALRGNLLAVIVGIAGLLYGAQGVGQAAQSAMNTVWNVPFRDRPNFFSRRLRGYAWLAVLGLATLISTVVAGFGAQVFPGALGWLWSQSVPFAINLGVFTVIFRVLVAAPLRWRDVRIGVLLAAVFWQGLQIGGGFYVSRTLNHASDVYGFFAIVIGLLSWLYLAAELTLFAAEVNVVIRDRLWPRSLLQPPLTPADRVVLARLTRMAIRRPELDVSVRFTDDAPALTRNPGPPGDPDSTGDPGSSPGAG
>NC_008578.1|WP_049751637.1|1859526_1859781_+|SHOCT-domain-containing-protein
MDWDTGPGWGGPTWAGWLGMSLMMALAVALIVAVVVWLTRMLSSAPEARREQREDALRILDERFARGELDEETYQRQRALLTRR
>NC_008578.1|WP_011720487.1|1856773_1859161_+|copper-translocating-P-type-ATPase
MAAETRHPTTNPTESEYADIELAISGMTCASCAARIEKKLNRLDGVRASVNFATEKAQVTFDPARVTPADLVATVEAAGYRARLPERVARAGAGSAQLHEPAAPGAGAAAAPAGTERSPVRSPAETPDDETTGVRTRLLISAALTVPVVLLAMVPSLQFRFWQWLSFTLAAPVVAWGAWPFHRATLINLRHRAVTMDTLISVGVLAAFGWSVWALFLGGAGEPGTHMRFELIPHAAGNHPDLYLEVASGVTTLILLGRYLEARAKRRSGAALRALLELGARDAAVIRDGAEVRIPVEQLAVGDRFVVRPGEKIATDGVVEEGTSAVDMSMLTGESVPVEVGPGSEVVGATVNVGGRLVVRATRVGADTALAQIARLVAQAQAGKAPVQRLADRISAVFVPVVIALAAATLLFWLADGASARFAFTAAVAVLVIACPCALGLATPTALLVGTGRGAQLGILIKGPDVLESTRRVDTVVLDKTGTVTTGEMTLLDVISAPGVSSEEALRLAGAVEDASEHPIARAIARAARERFGELPAVESFTATAGLGVVGVVEGHAVVVGRAAFLADWGLHPGAELTDAATKAETAGRTPIFAGWDGELRAVFVVADTPKPTSRAAVAELRRLGLRPVLLTGDNARTAEAIAAEVGIDEVVAEVLPAEKVAAIKELQARGRVVAMVGDGINDAAALAQADLGIAMGTGTDVAIEASDITVISGDLRAVVDAIRLSRRTLATIKGNLFWAFAYNVAALPLAAAGLLNPLIAGAAMAFSSVFVVTNSLRLRRFGVAHAPASGAASQ
>NC_008578.1|WP_148204689.1|1856507_1856714_+|cation-transporter
MMTTKTYTVEGMSCQHCVSAITAEVGKVPGVAGVTVDLAGKTVTVTGDAFEDAAIAAAVEEAGYTLVG
>NC_008578.1|WP_011720485.1|1856159_1856441_+|metal-sensitive-transcriptional-regulator
MVGYAGTKETVLARLRRIEGQVRGLHRMVEQDTYCIDVLTQISAATRALEAVALNLLEEHLRHCVHDAITAGGPEAEEKITEAADAIRRLVRS
>NC_008578.1|WP_011720496.1|1869577_1870222_+|hypothetical-protein
MSRPSRTRRSMVHAFLPYAAASLIPVLLLGVALALGYRAQARANGIARAQSQAHLLAQTAIEPILDGTPLGVALPSQEQMNLQRVVGQAVTAGSILRLRLRNLDGTVVYSDDGSGFSELPDDEALDAAHGQVIARLTRLGTDANDRGQPGVPAVEVYQPLTAGTRRRSGSASSSSTCPTSRSRRTSQRDSARRTTTWPSDSLRSTSPCWSSRRR
>NC_008578.1|WP_011720497.1|1870218_1871571_+|EAL-domain-containing-protein
MTRRLRTEVARNAYQARHDALTGLPNRAAFQRSGEAAVARAVSRRLGVRREGTTAVAVIDLDRFKAINDTLGPRNGDVLLRRIAERLASHTRKGDTVARLGGDEFGLILRDTADPHDALCRIRGLIESELDVAGIPLAVEASIGYAVTPDDAATIEELLQYADVAVHHAKARHLGVVRYHPSQNHYDAASLSLISEFRRAVTDNQLVLHYQPKAKLSDGAVEAIEALVRWHHPARGLLYPDVFVPLVEQTDLIDDLTRWVLRHALEDLATIGDPHLAVAVNISARNLSRHTFAADVKAAVRRAGIEPHRLVLELTETALLFDPTRAHDVFTDLTSYGIRVSIDDFGRGQTSLGYLSALPLSEIKIDRTFVRDMVTNAAHAAIVRSVVELGHNLGLIVVAEGVETAEVGDELRECGCDVAQGYWFARPMPLVDLRRWLAGSDRGDFSLAQL
>NC_008578.1|WP_041835039.1|1871752_1873699_+|S8/S53-family-peptidase
MATPRRRPVRRLTIVAAASSLGVVISSFAAPLAAHASPARSPVPHSRPGWLTHARDLGRAPATAAVQARIYLAPNGGLDALAARALAVSTPGSADYGHFLSPAEYFAEFGTTDATVRAVTRWLTSSGLTVTGVEAHNRYLDITGSVAAAERAFGVHIHAYSHDGQTVQAPDDTLTTPADLADDVLAVDGIDTTPNIVRPALAAGAVPYRGAPIPPPAGFRNAAPCSSYYGEKLATDLPSFNGQALPYAVCGYVGAQFRSAYEGATTLDGTGITVGITDAYASPTIAADAATYAVRNGDRPYAPGQLTQSLPRTFTNTKLCDASGWFGEETLDVEAVHAMAQGAKIRYYASSSCLDRDLLDAFARINDEARVQIVSNSWGAVEQSEHRSTILAYEQAFLQGAVEGISYVFSSGDSGDEVASSGTKQTDYPASDPFVTAVGGTATAIDATGRLAWETGWGTYRYALAPDGTAWSSSGTFLYGSGGGESTVFAQPIYQQGITPAGARGVPDVAMDADVTTGMLVGQTQAFPDGTYYDQYRIGGTSLAAPLFAGMTALTFQHARGGVGLLNPTIYRNAGTGVFTDVTGPGPDPGNVRVDYADGVDAAQGVVATVRTFNQDSSLAVGPGWDPVTGLGSANAGWLTAIPPRARR
>NC_008578.1|WP_041835040.1|1873705_1874368_-|helix-turn-helix-domain-containing-protein
MDPSSSAPDWGVIGCLAEPTRRRVYEAVRAAARPLTRDDVAQLVGIGRPLATFHLEALARTGLLDVTFARPAGRGGPGAGRPAKWYAVRNRDVIASLPPRRYELAAEILLRSVCAARATAELCAAAVEVGRRLGGTLTGRPLDEVLTRLGYQPIERDGGHAFANCPFHALVEADAETVCAMNQSLVTGLLEGLGIKELDAVVDPLPGGCCVRLRPRPPSG
>NC_008578.1|WP_011720500.1|1874429_1875068_+|GTP-cyclohydrolase-I-FolE
MRSQETISDVVPDTPLPDGRHPVLRVIPQPSIDLAAAERAAAAFLHALGIDLDSEVMAQTPKRMARGFAELLEPREFTLTTFPNTERYDEMVAARHIPFVSLCEHHMFPFVGFATVGYLPGDRILGLSKLARVVEHFARRPQVQERFTAQIARWLDEHLGPRGVGVIVDAEHLCMTIRGVRATGARTTTSALLGAFRDDPRVRAEFLDLAGD
>NC_008578.1|WP_148204582.1|1877156_1877684_+|hypothetical-protein
MAVAEQVFASSNPRAEYDKLNASDKASFDAVETPSSVTHTVVIRGLGANAGKTVDSLAAASSGSWWVSASWDEKALAGNTLFSYGQETKVYVSGGRVTSVQVLNMYSETSTPGWYQNGPNRSYTNNVGWEGRGIIQVDYALGVNGWNIQHVTPCGQLRLNANGYNYAVSSSCNPN
>NC_008578.1|WP_041835042.1|1877758_1877998_+|hypothetical-protein
MVAAIASVLLLVLPLVTPFVAAGGMVVSYLAGRGDKRTIFKVTFVVCALVFVGALVMDSTLLGASVSPGRPSIGHAPNS
>NC_008578.1|WP_011720505.1|1878388_1879972_+|ATP-dependent-DNA-ligase
MADRRPGDLREYRRRRNFCRTPEPAGRADPRHITRNSAEPRFVVQRHRATRLHYDLRLEINGVLVSWAVPKGPTLDPTVRRAAIHVEDHPLEYLDFEGAIPHGEYGGGDVIVWDTGTWRPHGTDDPAQAVVDGELHADFFGRKLRGRFVFVRRGTDEKSWLVLHKDDEHAVRGWNPEDYPRSVLSGATNDDVARHPRRLWRGGRAHPVAQHNDTEASADEIAALDALDDEGTWEVFGRRLKVTHLNKVIYPGRGRTHALTKRDLLRYAARIAPVVMPYLAGRPFTMHRFPDGIDAPGFWHKQLPSHAPDWLPRWQNPSAKRGEAATYLVVDEPAALIWAVNFGAIEWHAWTSRTDRPDLPTWALVDIDPGSRTTWRELVELALLHRDALDHLGVQGKPKLTGQRGIQIWIPIRRGPTFDDTRAWVEHLSKVVGSLMPDAVSWEWEKKRRAGRARLDFTQNAANKTLVAPYSPRPLPRAPVSAPVEWDELPHLRPDRFTVRTILDRLAERGDPFHALLTVNQQLPPLG
>NC_008578.1|WP_041835043.1|1880043_1880652_-|biotin-transporter-BioY
MSPVAGAPSSPAARPVLAERLLPVVRGRALDVILIVGVAALTALTAQFSVHIPGTPVPVTGQTFGVLLGAATVGAWRGFAGQLLYIAAGCAGLPVFAGGAHGVHQVFGPTGGYFVGFLLASVFVGWQARRGADRRVDTIAGAFLVGSVLIYLPGVTWLAMDLHVGLAKALELGVYPFVLGDVVKATLAGLLLPTAWRAVKRH
>NC_008578.1|WP_011720507.1|1880800_1881340_+|carbonic-anhydrase
MTTTSSSSTGSPTTADIFADVLDANRRFAASFEHAGLLGIAARQLAVLTCMDCRIDPLRVLGLAPGDAKILRNAGARVTPDVLATLAVAVHLLNVRRIMVMAHTRCRMASGTEDDLHQAIAHAGGPDTRSLAFLTTTDQTAAVQRDVQRIQSWPYLQGSGVAVGGFLYDVDTGDVHVVC

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Crispr_ID: NC_008578_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_12

1887773-1887904

Orphan

Consensus_repeat	Method
GCGCATTTCCAGCCACCGTGAATTGCCAG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_008578_12

>merge|NC_008578|12|1887773-1887904|CRISPRCasFinder
TCGGATTTCCAGCCGCCGCGCATTTCCAGCCACCGTGAATTGCCAGGTGGCTGCGCATTTCCAGGCGCTGCGCATTTCCAGCGGCTGCGCATTTCCAGCCACCGTGAATTGCCAGCCGCTGCGTATTTCCAG

>NC_008578|12|12|1887773-1887904|CRISPRCasFinder
TCGGATTTCCAGCCGCCGCGCATTTCCAG	CCACCGTGAATTGCCAGGTGGCT
GCGCATTTCCAGGCGCTGCGCATTTCCAG	CGGCTGCGCATTTCCAGCCACC
GTGAATTGCCAGCCGCTGCGTATTTCCAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_148204582.1\|1877156_1877684_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720517.1\|1893945_1894422_+\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
NC_008578.1\|WP_011720509.1\|1883182_1884160_-\|aldose-1-epimerase-family-protein	unknown	unknown	gnl\|CDD\|185699
NC_008578.1\|WP_041835043.1\|1880043_1880652_-\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|376871
NC_008578.1\|WP_041835042.1\|1877758_1877998_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720520.1\|1897211_1897949_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293802
NC_008578.1\|WP_011720507.1\|1880800_1881340_+\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|239474
NC_008578.1\|WP_011720513.1\|1887933_1888443_-\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_041835654.1\|1884468_1885557_+\|galactose-1-phosphate-uridylyltransferase	unknown	unknown	gnl\|CDD\|238341
NC_008578.1\|WP_148204690.1\|1896350_1897070_-\|ribonuclease-PH	unknown	unknown	gnl\|CDD\|178914
NC_008578.1\|WP_011720511.1\|1885553_1886543_+\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|224012
NC_008578.1\|WP_011720505.1\|1878388_1879972_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|240135
NC_008578.1\|WP_011720518.1\|1895715_1896351_-\|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl\|CDD\|234648
NC_008578.1\|WP_011720508.1\|1881503_1883096_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_008578.1\|WP_041835655.1\|1886602_1887742_+\|galactokinase	unknown	unknown	gnl\|CDD\|223231
NC_008578.1\|WP_148204583.1\|1895195_1895582_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_041835044.1\|1888868_1891955_+\|cell-wall-binding-repeat-containing-protein	unknown	unknown	gnl\|CDD\|173788
NC_008578.1\|WP_011720516.1\|1892489_1893542_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|176192
NC_008578.1\|WP_011720521.1\|1897964_1898756_-\|glutamate-racemase	unknown	unknown	gnl\|CDD\|234851
NC_008578.1\|WP_011720515.1\|1892060_1892387_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|197951

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_011720517.1\|1893945_1894422_+\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	3.38471e-76
NC_008578.1\|WP_011720509.1\|1883182_1884160_-\|aldose-1-epimerase-family-protein	gnl\|CDD\|185699	cd09022, Aldose_epim_Ec_YihR, Aldose 1-epimerase, similar to Escherichia coli YihR. Proteins similar to Escherichia coli YihR are uncharacterized members of aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism, catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen.	1.76498e-114
NC_008578.1\|WP_011720515.1\|1892060_1892387_-\|co-chaperone-GroES	gnl\|CDD\|197951	smart00883, Cpn10, Chaperonin 10 Kd subunit. The chaperonins are 'helper' molecules required for correct folding and subsequent assembly of some proteins. These are required for normal cell growth, and are stress-induced, acting to stabilise or protect disassembled polypeptides under heat-shock conditions. Type I chaperonins present in eubacteria, mitochondria and chloroplasts require the concerted action of 2 proteins, chaperonin 60 (cpn60) and chaperonin 10 (cpn10). The 10 kDa chaperonin (cpn10 - or groES in bacteria) exists as a ring-shaped oligomer of between six to eight identical subunits, while the 60 kDa chaperonin (cpn60 - or groEL in bacteria) forms a structure comprising 2 stacked rings, each ring containing 7 identical subunits. These ring structures assemble by self-stimulation in the presence of Mg2+-ATP. The central cavity of the cylindrical cpn60 tetradecamer provides as isolated environment for protein folding whilst cpn-10 binds to cpn-60 and synchronizes the release of the folded protein in an Mg2+-ATP dependent manner. The binding of cpn10 to cpn60 inhibits the weak ATPase activity of cpn60.	8.20926e-23
NC_008578.1\|WP_148204690.1\|1896350_1897070_-\|ribonuclease-PH	gnl\|CDD\|178914	PRK00173, rph, ribonuclease PH; Reviewed.	5.24284e-158
NC_008578.1\|WP_011720520.1\|1897211_1897949_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293802	cd07716, RNaseZ_short-form-like_MBL-fold, uncharacterized bacterial subgroup of Ribonuclease Z, short form; MBL-fold metallo-hydrolase domain. The tRNA maturase RNase Z (also known as tRNase Z or 3' tRNase) catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors. Two forms of RNase Z exist in eukaryotes, one long (ELAC2) and one short form (ELAC1), the former may have resulted from a duplication of the shorter enzyme. Only the short form exists in bacteria. Members of this bacterial subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.3078e-77
NC_008578.1\|WP_011720507.1\|1880800_1881340_+\|carbonic-anhydrase	gnl\|CDD\|239474	cd03379, beta_CA_cladeD, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	3.03414e-48
NC_008578.1\|WP_041835044.1\|1888868_1891955_+\|cell-wall-binding-repeat-containing-protein	gnl\|CDD\|173788	cd04056, Peptidases_S53, Peptidase domain in the S53 family. Members of the peptidases S53 (sedolisin) family include endopeptidases and exopeptidases sedolisin, kumamolysin, and (PSCP) Pepstatin-insensitive Carboxyl Proteinase. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of Asn in subtilisin. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Characterized sedolisins include Kumamolisin, an extracellular calcium-dependent thermostable endopeptidase from Bacillus. The enzyme is synthesized with a 188 amino acid N-terminal preprotein region which is cleaved after the extraction into the extracellular space with low pH. One kumamolysin paralog, kumamolisin-As, is believed to be a collagenase. TPP1 is a serine protease that functions as a tripeptidyl exopeptidase as well as an endopeptidase. Less is known about PSCP from Pseudomonas which is thought to be an aspartic proteinase.	2.06635e-79
NC_008578.1\|WP_041835654.1\|1884468_1885557_+\|galactose-1-phosphate-uridylyltransferase	gnl\|CDD\|238341	cd00608, GalT, Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme contains two identical subunits. It also demonstrates that the active site is formed by amino acid residues from both subunits of the dimer.	3.93197e-125
NC_008578.1\|WP_011720511.1\|1885553_1886543_+\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|224012	COG1087, GalE, UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane].	4.72586e-167
NC_008578.1\|WP_011720505.1\|1878388_1879972_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|240135	cd04865, LigD_Pol_like_2, LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-homologous end joining (NHEJ)-mediated repair of DNA double-strand breaks (DSB). NHEJ-mediated DNA DSB repair is error-prone. It has been suggested that LigD Pol contributes to NHEJ-mediated DNA DSB repair in vivo, by filling in short 5'-overhangs with ribonucleotides; the filled in termini would then be sealed by the associated LigD ligase domain, resulting in short stretches of RNA incorporated into the genomic DNA. The Pol domains of PaeLigD and Mycobacterium tuberculosis (Mt)LigD are stimulated by manganese, are error-prone, and prefer adding rNTPs to dNTPs in vitro; however PaeLigD and MtLigD belong to other subgroups, proteins in this subgroup await functional characterization.	8.11326e-114
NC_008578.1\|WP_011720518.1\|1895715_1896351_-\|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	gnl\|CDD\|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	8.79417e-98
NC_008578.1\|WP_011720508.1\|1881503_1883096_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.66466e-58
NC_008578.1\|WP_041835655.1\|1886602_1887742_+\|galactokinase	gnl\|CDD\|223231	COG0153, GalK, Galactokinase [Carbohydrate transport and metabolism].	1.92811e-116
NC_008578.1\|WP_011720521.1\|1897964_1898756_-\|glutamate-racemase	gnl\|CDD\|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	1.24618e-128
NC_008578.1\|WP_011720516.1\|1892489_1893542_-\|glucose-1-dehydrogenase	gnl\|CDD\|176192	cd08230, glucose_DH, Glucose dehydrogenase. Glucose dehydrogenase (GlcDH), a member of the medium chain dehydrogenase/zinc-dependent alcohol dehydrogenase-like family, catalyzes the NADP(+)-dependent oxidation of glucose to gluconate, the first step in the Entner-Doudoroff pathway, an alternative to or substitute for glycolysis or the pentose phosphate pathway. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossman fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.	6.5631e-155
NC_008578.1\|WP_041835043.1\|1880043_1880652_-\|biotin-transporter-BioY	gnl\|CDD\|376871	pfam02632, BioY, BioY family. A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin. BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes.	2.44029e-35

>NC_008578.1|WP_041835655.1|1886602_1887742_+|galactokinase
MFVARFGGDPAGVWSAPGRINLIGEHTDYTGGCVLPVAIDRRTYVAARPRPDGMLRIVSHAYAGQPPVFLGSADLHPESAAHQGWAAYVAGILWVFRNRTEIPDGFDIAVYSTVPIGAGLSSSAALECAVAAAVADLTATAVPPSELARLAQYAENAYVGVPCGILDQMAACVCQAEHALFFDIGAGRYEHIPFAPESHGLVLLVADTGISHRHASGEYAKRRESCRQAEDILGVPRLGDIRAASLETVLAALPDETLRRRVRHVVTENERVRRTVELLRSGRLAEIGPLLLASHASLRDDYAVSTPELDAAVEAAISGGAIGARLTGGGFGGSIIALAPRDRVPQVVAQIQGAFTSRGWKPPAAPLIPRIADGVRRDA
>NC_008578.1|WP_011720511.1|1885553_1886543_+|UDP-glucose-4-epimerase-GalE
MKVLVTGGAGYIGSVVTRVLIEDGHDVVVLDDLSTGHRDAVPAGVPFVHADIADAGDVLAREPFDGVLHFAAKSLVGESMNRPELYWATNVCGTRHLLDAMRRHSVPRLIFSSTAAVYGEGGPDGIGEDTPPRPTSPYGTSKLAVDLMISDECRAYPLGAVSLRYFNVAGAYGPCGERHRTETHLIPITLDVAAGRRPHLEIYGNDWPTPDGTCMRDYIHVLDLARAHVVALQHARPGHHAIYNLGNGRGFSVREVVAAVERVTGRRVPVTVAPRRPGDPAWLVADDSRARAELNWQPQADLDTIIADAWAFHQQRRHTDGLAGGGTTS
>NC_008578.1|WP_041835654.1|1884468_1885557_+|galactose-1-phosphate-uridylyltransferase
MPIVTQLADGREIRYYDDPGVPIDHGDLVDHRELPSMTPTSIRRFDRLLDEWVTIAGHRQSRTYLPPDDECPLCPSKQGRQSEIPARDYHVVVFENRFPSFTTTARVPSDGDGFFVTEPGLGRCEVVCFTSDHTAAFSSLPVTRVRTVIDAWIDRTLELSRLPYVEQVFCFENRGSEIGVTLSHPHGQIYGYPFVTPRTRRMLDSARAHHERTGRNLFADIVAAEVAAGTRIIAGNAHWVAFVPYAARWPLEVHLYPRRRVPDLPALNDAERDALAPIYLEVVRRMEHVYPDTMPYIAAWHQAPVRVGRELAYLHLELFSIRRAPGKLKFLAGSESAMGAFINDVLPEEAADMLRTVSIDPS
>NC_008578.1|WP_011720509.1|1883182_1884160_-|aldose-1-epimerase-family-protein
MHESPGRSVDNEVSPHNEVSLHRGATTLVVARRGAAVQVLRVGDRDVFQPAVPGETGAFTGCVLTPWPNRIADGRYRFAGVEYQLPINEPETGSALHGLGWDVDWRVLDVGSDDKTEYVDLRLDATPVDGYPFHVVTTVRYTLVDDGIRVDALAENVGRQPCPYALGFHPYLSAGRTPTGGEASVDDCTLRLGVRRRFLTDARQIPVGDVAADGWLDGYPLAGRRLDDGFFDVVVENDGLVHARLSRPDGFVVDLWAEPVFAFWQVYTGDKRAAAYARRGIAVEPMTAAPNAFNNHQGLLILAPGESFSAAWGVTLRPADADGWA
>NC_008578.1|WP_011720508.1|1881503_1883096_-|MFS-transporter
MRIRQLLPSTLAGRDAVHRRGLGLAAVCTLLFLTFLDNTIVSVALGDIQQRLSAGVQSLQWVVNAYALTFASAMLLAGALGDRVGERKVMFSGAAVFCIGSVICAVAPDTSVLIAGRGVMGIGAAASEPGTLAMIRYLFPGRRERARATGVWAGVSGLALALGPVIGGIIVGLSSWRWIFWFNLAFGVAALAIAAIVVPETPRVPSRRIDLVGGLLGAGSLALLVFGVLRGELDGFGAAHVISLLVASVVVGLVFLWWQFHASEPLIPPQFLRMPAFVVPNIVAFATYFGTFAVFFFAALYLNIVVGFSGLRIALQFIPMMVIMIAASVLTGRWIGRTGARRPVVLGCGVFTLGLLLTDGALTRHPHYLPLAASLALAGLGIGITVVPTAFAAMSAVPVDRAGVASSAVNTSREIGAVVGTAVLGAIVNSALISHATSTLNALGWSKLKGFVTSAILNGGASLGGPLGQASPEIQKLVNALYDAFAEGLHIALVLSACLVLAAGVLAASVRGPRLAESEETALGHVHLPS
>NC_008578.1|WP_011720507.1|1880800_1881340_+|carbonic-anhydrase
MTTTSSSSTGSPTTADIFADVLDANRRFAASFEHAGLLGIAARQLAVLTCMDCRIDPLRVLGLAPGDAKILRNAGARVTPDVLATLAVAVHLLNVRRIMVMAHTRCRMASGTEDDLHQAIAHAGGPDTRSLAFLTTTDQTAAVQRDVQRIQSWPYLQGSGVAVGGFLYDVDTGDVHVVC
>NC_008578.1|WP_041835043.1|1880043_1880652_-|biotin-transporter-BioY
MSPVAGAPSSPAARPVLAERLLPVVRGRALDVILIVGVAALTALTAQFSVHIPGTPVPVTGQTFGVLLGAATVGAWRGFAGQLLYIAAGCAGLPVFAGGAHGVHQVFGPTGGYFVGFLLASVFVGWQARRGADRRVDTIAGAFLVGSVLIYLPGVTWLAMDLHVGLAKALELGVYPFVLGDVVKATLAGLLLPTAWRAVKRH
>NC_008578.1|WP_011720505.1|1878388_1879972_+|ATP-dependent-DNA-ligase
MADRRPGDLREYRRRRNFCRTPEPAGRADPRHITRNSAEPRFVVQRHRATRLHYDLRLEINGVLVSWAVPKGPTLDPTVRRAAIHVEDHPLEYLDFEGAIPHGEYGGGDVIVWDTGTWRPHGTDDPAQAVVDGELHADFFGRKLRGRFVFVRRGTDEKSWLVLHKDDEHAVRGWNPEDYPRSVLSGATNDDVARHPRRLWRGGRAHPVAQHNDTEASADEIAALDALDDEGTWEVFGRRLKVTHLNKVIYPGRGRTHALTKRDLLRYAARIAPVVMPYLAGRPFTMHRFPDGIDAPGFWHKQLPSHAPDWLPRWQNPSAKRGEAATYLVVDEPAALIWAVNFGAIEWHAWTSRTDRPDLPTWALVDIDPGSRTTWRELVELALLHRDALDHLGVQGKPKLTGQRGIQIWIPIRRGPTFDDTRAWVEHLSKVVGSLMPDAVSWEWEKKRRAGRARLDFTQNAANKTLVAPYSPRPLPRAPVSAPVEWDELPHLRPDRFTVRTILDRLAERGDPFHALLTVNQQLPPLG
>NC_008578.1|WP_041835042.1|1877758_1877998_+|hypothetical-protein
MVAAIASVLLLVLPLVTPFVAAGGMVVSYLAGRGDKRTIFKVTFVVCALVFVGALVMDSTLLGASVSPGRPSIGHAPNS
>NC_008578.1|WP_148204582.1|1877156_1877684_+|hypothetical-protein
MAVAEQVFASSNPRAEYDKLNASDKASFDAVETPSSVTHTVVIRGLGANAGKTVDSLAAASSGSWWVSASWDEKALAGNTLFSYGQETKVYVSGGRVTSVQVLNMYSETSTPGWYQNGPNRSYTNNVGWEGRGIIQVDYALGVNGWNIQHVTPCGQLRLNANGYNYAVSSSCNPN
>NC_008578.1|WP_011720513.1|1887933_1888443_-|hypothetical-protein
MHSPGPIRLDPLAMAWNTVASFSTYEEAQAAVDYLSDHHFPVEYVDIVGSDLRILERVTGRLTTTRAAAAGAASGAWFGLFIGLLVGLFTNGPRWLGLVLGGVIIGALWGATFGAVGHLATRGRRDFASMRSLVALKYDVVARGGHAEQARAMLRDGGILVEEPPQAEA
>NC_008578.1|WP_041835044.1|1888868_1891955_+|cell-wall-binding-repeat-containing-protein
MTTIGLLVVVLGWTAHAASSDHAEQTQLRRVATPPISALAVNAQPSDAAVPLVLDSAAPAAIAGPPQIPQPDTANASTSGRVPTTRPLAGDTPVQATIALRSAVVPSAIDAGIHRLRTNGLSVTLLGDPPVALLVHGTARQVNRVFRTSVVSYRGIADQEILTFAMPPALPADLAAATGTAFVRRGQATSAHRLTAVPAAFSTAGGAVSPQPCTAAANAASATGAHTADQIASHYNIGPLYAAAPQRPVTVALVEFEPFNPADIAAFQQCYGTHATVTTVQVDGGAGAGTGSGRAATDIEMVIAAAPDANIVVYQAPGDTGSVYDTYARIAADNTAQVVVTSWGICEPTATVSSLPTLERPLFEQMARNGQTVLAAAGDSGSAACYAPPSATDTSLAVLDPASQPTITAVGGTSFAGVSDPDISWHTAGGAGGGGISHIWPMPRYQAGATTTQNSPALCNAPTGSACRQVPDISMLADPTHGYVAYVGGTWRAVGGTGAATATFAGILALIDESCVAGPVGLINPALYRLAGTSAVVDVTQGPNTDLTGTNGGAYPPATGVDLATGLGRPDAAALAAALCPPTGAAGSGTITVDPNLVVTNSSTSLTFRYTPASGTGMVNGELDITVPGTWSLPTTTSGQPGYTTADAGVLTVSGNTIVLRSITLPANSTVTVTFGDTSGGPGARTPSAAQITTFATASAPASAGGAAGLARNPAVRVLTPGGSQAGQGTLLRIAGADRIGTAIAASQLRFTTGGASAVVLARADIFPDALAGVPLAAQVHGPLLLTPPSSLPIAVLNEIQRVLPVGGPVFLLGGTAALSATVEQQLVTLGYLPHRISGMDRFDTAVQIAHALGDPTTILECSGLDFPDALSAGPAAVITHGAVLLTAGPDQAAATAAYLTVHPRVTRYAIGGPAAHADPGAIPLVGADRYATSVLVAQQFFTAPSGIGLASGAAFPDALAGGPATAEAGGPLLLVPPSGALPTGTANYFSAVASSVLTGWLFGGTAAVGTDIASETAQALVLVPPPS
>NC_008578.1|WP_011720515.1|1892060_1892387_-|co-chaperone-GroES
MERTATGVPIKLLHDRVLVKAEGPAGERRSTGGIVIPATASVGRRLVWAEVVGVGQTVRSVQPGDRVLYEPEDRAQIEIHGVSYVLLRERDIHAVAAERVEGSTGLYL
>NC_008578.1|WP_011720516.1|1892489_1893542_-|glucose-1-dehydrogenase
MSVRALSVVPGKPETAQVGDHPDPPESDGSVLVDGLLIGICGTDVEILREGYGWAPPGEERLVIGHESLGRVAAAPPDSGFSPGDLVAGIVRRPDPVPCVPCSLGAWDFCRNGRYTERGIKERHGYAANQWRIEPEFAVRLDPTLGDLGVLLEPTSVVAKAWDQAEKVAARSPAPRHVALVTGAGPIGLLAALLGVQRAYQVHVFDQVTTGPKPDLVADLGATYHTGDIAGIGVQPDVVIECTGHGPLVFALTDVVATDGVICLTGISASKRQAAMRPDEVNKEMVLDNLALVGSVNASRAHYEAAAAALAAADRSWLARLITRRVPLERFDQALERQDGDVKVVLELAH
>NC_008578.1|WP_011720517.1|1893945_1894422_+|thioredoxin-dependent-thiol-peroxidase
MPKLTVGDAAPDFTLPDADGKPVALRDFRGRQVIVYFYPAAMTPGCTTEACDFRDNLAALDSRNIAVVGISPDPVEKLAKFRDAYHLTFPLLSDVDKNTLIAYGAYGEKTNYGKTVMGVIRSTFIVGADGRIEHAFYNVKATGHVARLLDELGFTQQP
>NC_008578.1|WP_148204583.1|1895195_1895582_+|hypothetical-protein
MTEWLADALSFFRAVVGVLLRHAVDRSAKRRDDNQKLLRKAIKALNRVQISYQGVLDKKKYKHRREKLLRKARVRVADAYALHRPQPEQLKEYLDHKNWSLEDVRKVRDILCELYHSQRKRTPSDVDR
>NC_008578.1|WP_011720518.1|1895715_1896351_-|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase
MATSSSARRVVLATRNPHKLVELRRILSAAGLDSIELVGADAYPGLPEVAETGDSFEANARLKARAVCAFTGELAIADDSGLVVDALGGMPGIFSARWSGSLAGNQDRDRANLQLVLDQLADVPDDRRTAKFVCAAVAALPDGREFVAHGEVHGVITRAPRGTNGFGYDPIFELPSGRTTAELEPAEKDAVSHRGRAFRALVEILSAHGVW
>NC_008578.1|WP_148204690.1|1896350_1897070_-|ribonuclease-PH
MRVDGRAADELRPVRFTRGWLLHAEGSVLVEFGRTRVLCAASVLEGVPKWRKGTGLGWVTGEYAMLPRATTTRTDRESVRGRLGGRTQEISRLVGRSLRACVEPARLGENTVHLDCDVLQADGGTRTAAITGAYLALADACRWMRDHGWVTSDPLVRSVAAVSVGIVDGVPVLDLCYDEDVRAGTDMNVVMTGDGDFVEIQGTAEGTPLRRDEVDALLELATRGCARLTELQRTALAEA
>NC_008578.1|WP_011720520.1|1897211_1897949_-|MBL-fold-metallo-hydrolase
MRWTVIGCSGSFPGPANACSSYLVEHDGFRLLIDIGNGALGALQNFCDPRDVDAVVVSHLHGDHWLDLVPLAYARPHHPDGRVPPSLPVLLPDPQPLYVLTGKDAAALRPVFDVRPIVDGEVGPFSVTFIPTVHPVNTYAMRIRVGGISIGYTADTAWSDRLAPFFSGVDLLVAEATFPARENGPPGLHLTAVEAAELANRSGAGRLLLTHIPPWLDPQVQYADAVATFTGRVDLARPGWSVRLD
>NC_008578.1|WP_011720521.1|1897964_1898756_-|glutamate-racemase
MRNLPIGVFDSGVGGLTVARAILDLLPHEPLYYVADTAHFPYGTKSIAEVRQYGLAVLDRMVADGVKLLVIACNSASSALLRDARERYDVPVVEVIQPAVRKAVSATRNGKVGVIGTPATIASMAYDDAFAAAPHVDLTTAACPRFVEFVEAGITMSDELLECAKEYLAPIVERGCDTLILGCTHYPFLAGAIALVVGDEVMLVSSADETARDVYRVLVSRGLTRPASAPPPVHRFAATGDPEPFSRLGRRFLGPEIGHVTTL

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Crispr_ID: NC_008578_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_13

2003883-2003957

Orphan

Consensus_repeat	Method
GGCCGTTCCGGCTGGCGGGCGTGGCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_13

>merge|NC_008578|13|2003883-2003957|CRISPRCasFinder
GGCCGTTCCGGCCGTTCCGGCTGGCGGGCGTGGCGGCCGGTCCGGTGGCGCGTGGCGGCCGGTGGCCGTTCCGGC

>NC_008578|13|13|2003883-2003957|CRISPRCasFinder
GGCCGTTCCGGCCGTTCCGGCTGGCGGG	CGTGGCGGCCGGTCCGGTG
GCGCGTGGCGGCCGGTGGCCGTTCCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_148204592.1\|2005318_2006665_+\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|270872
NC_008578.1\|WP_011720607.1\|2009132_2009402_+\|mycoredoxin	unknown	unknown	gnl\|CDD\|131255
NC_008578.1\|WP_049751479.1\|1997248_1997959_-\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
NC_008578.1\|WP_011720609.1\|2011208_2011703_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_008578.1\|WP_169303206.1\|1998220_1999954_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237447
NC_008578.1\|WP_011720612.1\|2018752_2019943_-\|adenylyltransferase/sulfurtransferase-MoeZ	unknown	unknown	gnl\|CDD\|181156
NC_008578.1\|WP_049751482.1\|2007389_2008922_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_008578.1\|WP_169303207.1\|2003659_2003818_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720591.1\|1989713_1990493_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NC_008578.1\|WP_148204590.1\|1991044_1991251_-\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_049751483.1\|2015283_2018562_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_008578.1\|WP_083760570.1\|2002545_2003175_-\|M48-family-metallopeptidase	unknown	unknown	gnl\|CDD\|320703
NC_008578.1\|WP_011720610.1\|2011689_2015184_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_008578.1\|WP_011720599.1\|2000028_2001756_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_008578.1\|WP_011720603.1\|2004099_2005278_+\|TOMM-precursor-leader-peptide-binding-protein	unknown	unknown	gnl\|CDD\|238386
NC_008578.1\|WP_041835682.1\|1994884_1995664_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_008578.1\|WP_011720594.1\|1991733_1994763_-\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NC_008578.1\|WP_041835067.1\|2006767_2007052_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NC_008578.1\|WP_011720600.1\|2001762_2002440_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_008578.1\|WP_011720608.1\|2009514_2010924_-\|dipeptidase	unknown	unknown	gnl\|CDD\|349929

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_148204592.1\|2005318_2006665_+\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|270872	cd13970, ABC1_ADCK3, Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3. This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.	2.9033e-90
NC_008578.1\|WP_011720607.1\|2009132_2009402_+\|mycoredoxin	gnl\|CDD\|131255	TIGR02200, conserved_hypothetical_protein, Glutaredoxin-like protein. This family of glutaredoxin-like proteins is limited to the Actinobacteria and contains the conserved CxxC motif.	1.08004e-30
NC_008578.1\|WP_049751479.1\|1997248_1997959_-\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	6.85475e-33
NC_008578.1\|WP_011720609.1\|2011208_2011703_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.45781e-22
NC_008578.1\|WP_169303206.1\|1998220_1999954_-\|hypothetical-protein	gnl\|CDD\|237447	PRK13613, PRK13613, lipoprotein LpqB; Provisional.	5.1913e-51
NC_008578.1\|WP_011720612.1\|2018752_2019943_-\|adenylyltransferase/sulfurtransferase-MoeZ	gnl\|CDD\|181156	PRK07878, PRK07878, molybdopterin biosynthesis-like protein MoeZ; Validated.	0
NC_008578.1\|WP_049751482.1\|2007389_2008922_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	8.71152e-86
NC_008578.1\|WP_011720591.1\|1989713_1990493_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	5.83951e-06
NC_008578.1\|WP_049751483.1\|2015283_2018562_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	3.10788e-72
NC_008578.1\|WP_083760570.1\|2002545_2003175_-\|M48-family-metallopeptidase	gnl\|CDD\|320703	cd07344, M48_yhfN_like, Peptidase M48 YhfN-like, a novel minigluzincin. M48 YhfN-like protease is considered as a CaaX prenyl protease 1 homolog, with most of the sequences in this family as yet uncharacterized. It contains the zinc metalloprotease motif (HEXXH), likely exposed on the cytoplasmic side. It is probably associated with the endoplasmic reticulum (ER), regardless of whether its genes possess the conventional signal motif (KKXX) in the C-terminal. Proteins in this family proteolytically remove the C-terminal three residues of farnesylated proteins. This novel family of related proteins consist of the soluble minimal scaffold similar to the catalytic domains of the integral-membrane metallopeptidase M48 and M56, thus called minigluzincins.	1.66472e-18
NC_008578.1\|WP_011720610.1\|2011689_2015184_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	2.70127e-81
NC_008578.1\|WP_011720599.1\|2000028_2001756_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.43713e-55
NC_008578.1\|WP_011720603.1\|2004099_2005278_+\|TOMM-precursor-leader-peptide-binding-protein	gnl\|CDD\|238386	cd00757, ThiF_MoeB_HesA_family, ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD and ThiS, respectively, on the alpha-phosphate of an ATP molecule bound at the active site of the activating enzymes, leading to the formation of a high-energy acyladenylate intermediate and subsequently to the formation of a thiocarboxylate at the C termini of MoaD and ThiS. MoeB, as the MPT synthase (MoaE/MoaD complex) sulfurase, is involved in the biosynthesis of the molybdenum cofactor, a derivative of the tricyclic pterin, molybdopterin (MPT). ThiF catalyzes the adenylation of ThiS, as part of the biosynthesis pathway of thiamin pyrophosphate (vitamin B1). .	2.17724e-12
NC_008578.1\|WP_041835682.1\|1994884_1995664_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.9756e-81
NC_008578.1\|WP_011720594.1\|1991733_1994763_-\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NC_008578.1\|WP_041835067.1\|2006767_2007052_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	6.88918e-14
NC_008578.1\|WP_011720600.1\|2001762_2002440_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.44614e-88
NC_008578.1\|WP_011720608.1\|2009514_2010924_-\|dipeptidase	gnl\|CDD\|349929	cd05680, M20_dipept_like, uncharacterized M20 dipeptidase. Peptidase M20 family, unknown dipeptidase-like subfamily (inferred by homology to be dipeptidases). M20 dipeptidases include a large variety of bacterial enzymes including cytosolic nonspecific dipeptidase (CNDP), Xaa-methyl-His dipeptidase (anserinase),and canosinase. These dipeptidases have been shown to act on a wide range of dipeptides, but not larger peptides. For example, anserinase mainly catalyzes the hydrolysis of N-alpha-acetylhistidine while carnosinase degrades beta-alanyl-L-histidine.	0

>NC_008578.1|WP_169303207.1|2003659_2003818_+|hypothetical-protein
MAEKYNGEAYCVKCKEKRQFEGDVVVNDKGTKMARGKCPVCGTTLNRILGKA
>NC_008578.1|WP_083760570.1|2002545_2003175_-|M48-family-metallopeptidase
MTASSGSRSRGSQRSYRSTPTPPRRSVSVERVLLDGSTLVEIRRSLRRRRTISAHVDGDHIVVSVPARLSRAEREKWVRIMVERLARRRGRQDAADSDQRLLRRAVQLSRRYLGGRAQPASVRWVANQESRWGSCTPESRSIRLSKRLQVMPSWVRDYVLLHELVHLIDPTHGPRFHALLNQFPWAERAKGYLQGISDAALLRSHRGSA
>NC_008578.1|WP_011720600.1|2001762_2002440_-|response-regulator-transcription-factor
MKGRVLVVDDDTALAEMLGIVLRGEGFEPHFVFDGDKALAAFREVKPDVVLLDLMLPGTDGIDVCRQIRAESGVPIVMLTAKSDTVDVVVGLESGADDYVVKPFKPKELVARLRARLRRTDEPAPEILTIGDVTIDVAGHSVTRDGQPIPLTPLEFDLLVALARKPRHVFSREVLLEQVWGYRHAADTRLVNVHVQRLRSKIEKDPDHPEIVLTVRGVGYKAGPA
>NC_008578.1|WP_011720599.1|2000028_2001756_-|HAMP-domain-containing-histidine-kinase
MAVLDDAAPAPDGRRPPSGDEPAAVHSVPAAWHRRGFPVGRIARAIGHRWRRSIQFRVVATTLLVSAAVVALLGLVVLQQVRAGLLQAKVRSSVNQELIGLASAQQSLTSSANAITALTNTVKSLSPPDTSRRQPGGYEVVAFQVLSPGVVAKNQPAADVDFRVSSIPDDLIAAVSQGQARYYYAYTVMQYTDGFQVPGLAIGSLVTTPSNQQYEIYYVFSLQQEQQTLELVTRTLLVSGLGLVALLAAIAYLVTRQVVKPVRVAAQIAERLADGRLQERMTPKGEDDLARLAASFNKMAESLQRQIRRLEHLSRVQRRFVSDVSHELRTPVTTIRMAADVLFEARHGFDPASARSAELLQNQLDRFESLLADLLEISRHDAGAASLEADVVDVRDLVRHVVEDTEPLAARRGSIVQVIVPAEACLCEADGRRVERILRNLLVNAAEHGEGRPIVVRVAAGEDAVAVAVRDHGIGLRPGEAALVFNRFWRADPARARSTGGTGLGLAIALEDARLHGGTLQAWGEPGKGSQFVLTLPKRVGFPISRPPIPVEPEDAAASPSGAGSASVAAERAVP
>NC_008578.1|WP_169303206.1|1998220_1999954_-|hypothetical-protein
MTVPTGGRVHAGSQASQDSQGGRNIQVPAAYAVEGLSPKDVVGGFRLASAVLSNPAIARSYLADPTWQPTEGVHVIDESGESVVYAINGDTATVRVIDKWVGTIFTDGTYQPQPNGATSDVTYTLTKSAPQSKGEWRISKLPNFLVLDRTEVENAFWQGSLYYLSPGGQFLVPVRVFLPHTATDVATALVEQLSQPVPGWLAHAGVFSALPQTDQAPTVTVSGDVATVDLPPPFGNLNAIERDQASAQLTYTLVRSGVASQVRITVGGAPLPNSRQAVTQTLKTWSAFDPDVLRTATFTYIDDAGVPRLANGAPLLSPPLPEPTATKGTGTAAPGPRPRFVSAVVAPRLVGSSGPDLVAGVTRNPDNTQTLYAGPINAVVPVLSAASFSTPSWDLLGNVWTVEQVSTGAQEILVGVVTPTTTPKFQRVNIDGTLASSLIVSLKVSRDGTRVALVVRSTTGSQLWVGRVERSDRGVTIGGLYPVAPNVQPAADGVAWASATSLAILATSSGSEIVTAWLVDVDGWDATIQQVPFDASSLTAAPNQPLAIGTKSRQVEVLNGSAWQVVVDGGTVPNYPS
>NC_008578.1|WP_049751479.1|1997248_1997959_-|ComF-family-protein
MSWLRAAGRAVAELLVACACPGCGRDAPPGSLCAVCDAAIRAGPLVARQLAEGVPVVAAGGYEGPLRRLLLAYKEHGRRDLRDVLAALLVRNLDFLAATADRIVVVPIPSTRTALRARGWEPVAELARAAAHAAVPPTRVARLLRCRRTVADQAALAATERFVNLAGAYTVSPGMAARFRREQADPPRRTAVLVLDDIVTTGATLGEAVRALRAGGVPVFGAVTVAATRLRRGGTC
>NC_008578.1|WP_041835682.1|1994884_1995664_-|response-regulator-transcription-factor
MRPPYPGGNRAHGANGPAPASGPAPATAPDAPATDATGDVDPIKVLVADDHALFRRGLEMVLRQEPDIQLVAEASDGAEAVARAAETLPDVVLLDVRMPKRTGIEACAAIKEVCPSAKIIMLTISDEEADLYEAIKAGAMGYLLKEISIDEVAAAIRAVHGGQSLISPSMASKLLNEFASLIKRGDARHQVPAPKLTEREMEVLRLVAKGLNNRDIAKQLFISENTVKNHVRNILEKLQLHSRMEAVVYAVREKLLEIT
>NC_008578.1|WP_011720594.1|1991733_1994763_-|preprotein-translocase-subunit-SecA
MPALLDKLLRAGEGKILRKLKAIAEQVNSIEDEFAKLSDGELRGLTDEFRARYADGESLDDLLPEAFAAVREAAKRTLGQRHFDVQIMGGAALHFGNIAEMKTGEGKTLVSTLPAYLNALAGRGVHVVTVNDYLARRDAEWMGRIHRFLGLEVGVISPQMGPAERKKAYAADITYGTNNEFGFDYLRDNMAWSVDEIVQRGHFYAIVDEVDSILIDEARTPLIISGPVDMNQKWYTDFAKLAERLQRGENGEGDYEVDEKKRTISITERGVQRVEDWLGIDNLYEPTNTPLVGYLHNALRAKELYKRDRDYVVIDGEVLIVDEFTGRILYGRRYNEGMHQAIEAKEGVPIKQENQTLATITLQNYFRLYEKLAGMTGTAMTEANEFHQIYKLGVVPIPTNRPMIRIDQPDVVFKTEKAKFAAVVEDIAQRHAKGQPVLVGTTSVEKSELLSGMLLRRGIPHAVLNAKYHEKEAAIVAQAGRKGAVTVATNMAGRGTDIMLGGNPEFLARQELAERGLSPVDTPEEYEAAWPEVLEKWKKAVAAEHDEVVQLGGLYVLGTERHDSRRIDNQLRGRSGRQGDPGESRFYLSLEDDLMRLFNGPMVQRIMETLNYPEDVPLESKMVTRAIRSAQTQVEQQNFEIRKNVLKYDEVLNKQRAVIYAERRRVLHGDDLHEQVGHMIDDVIRDYVRAATEEGYAEDWDLEQLWTALRSLYPVGLTIDQVVAECGGDRSGLTAEFLIERLTEDAHRAYAEREAALGTLPDGQPVIRELERRVVLAVLDRKWREHLYEMDYLQEGIQLRSYGQRDPLVEYQREGYTMFQTMLDGIKEESVRLLFSVDVQVTPVAEAPVAATAAADGAGTAAEGTAGVAVPQPAGASGPALQPVPAATAPGQQPVPAAAALSPGAGMRLADSPVAKLLAPPRPTRLQYTAPTIDGAAGSGEATAMTVDERRPSGAAARGPSPASASRQRAGAGEQARPLMYAGTPRSAKCPCGSGKPYKRCHGDPRNAG
>NC_008578.1|WP_148204590.1|1991044_1991251_-|hypothetical-protein
MDRVLRDAADARRDARLDAVRDAGDVSPDAADATRAAGRNAVRDPARDAALGRGAGGLWTGLMGELPC
>NC_008578.1|WP_011720591.1|1989713_1990493_+|LysM-peptidoglycan-binding-domain-containing-protein
MYSEVNASKRWHLRAAWVALLVTGMGVIALWAGGSPRRLLAALQHPADFDALIRCVAASVALVLCAWFLFAIVGVLAAHLAAAASRTPRRLLLGIAAVLDRVTPRVIRRLARAAVGATLALGPVAGYSAPSWAVPSAPPGATSGSVAADAGSFTLDWPTVPSSSPPTAPSDRWPTVPSGSPRSLPPPDDPSGDIHVVVPGDTLWDIAGKHLAARDGGHPPSAAAIAKEWPRWYAANRVIIGGDPNLLFPGERLQPPAES
>NC_008578.1|WP_011720603.1|2004099_2005278_+|TOMM-precursor-leader-peptide-binding-protein
MRPRLKPAVRVLWRDAATVQFGVDARSAVAVTGVDPCTAALFDALDGSRTDAELRVLGRQLGLDASSVDRLLDWLRSGRLLDDAARRPAEALLPRGAEDLLTPDLAALSLLSEEPDGGAVLLERRRAARISVVGAGRVGATVATLLAAAGIGRVVPDDPEPATAADCAPGGLAPADAGTPRGDALRRRLLAVNPAVQTAPPTDGDYTLQVLAPPGPFDATVGDAALRGHTPHLLAFVRDLTGVIGPLVSPGRSPCLRCLEAARAARDPRWPLIAAQLASDPPRKRRACDVVLATLVAAIAALQVLAFVDGRRPATVGATVEMTLPDWRFRRRRWSMHPDCGCGWPSNAEPDAGIDPGSGRGIGAAPGGGVGPGRAVGPSVSVGARSGVGMNA
>NC_008578.1|WP_148204592.1|2005318_2006665_+|AarF/ABC1/UbiB-kinase-family-protein
MADIPRGTVARTARLARLPLSAAGRTAVGIGKRLTGRPAEEVIGEFQRRTAEQLFDVLGELKGGAMKLGQALSVFEAAMPDDLAAPYRESLTRLQENAPPLPAATVHRVLAGQLGPQWRTYFRDFEDRPAAAASIGQVHRAVWQDGRHVAVKIQYPGAGKALLSDLTQLGRLGRVFGVLFPGLDLKPLLQELRARVTEELDYRLEAMSQHAFARAYLDDPDIYVPDVLAGADRVIVSEWIDGTPLSSIIRSGTRRQRDHAGLLLVRFLFSGPARVGMLHADPHPGNYRLLDDGRLAVLDFGAVNRLPGGFPPIIGRLLSLALREEPDAVLEGLREEGFVRARRSVDPHDLLAYLNPFLDPVRYPVFHFTRRWLREQASRIGDPRTPSGALARQLNLPPSYLLIHRVWMGSIGILCQLDAAGPFRAEIERWLPGLELPELVEDAEQSAE
>NC_008578.1|WP_041835067.1|2006767_2007052_-|WhiB-family-transcriptional-regulator
MSVTDVDAGCAQAIDARREIPCLQVNPEIFFAEDPEDIDVAKALCRRCPRRVACLDDALQRREPWGVWGGELFSGGRVVSQKRPRGRPRKERVV
>NC_008578.1|WP_049751482.1|2007389_2008922_-|ATP-dependent-helicase
MTVSRAVSGVDVLAALDDDQRAAVTAMPGPVGILAGPGTGKTRTIAHRIAHAVQSGQWRPQQVLAVTFTNRAAAELRHRLRMLGVDDVSTGTFHAVALRQLRYFWPRLVGGAFPRIVADKTPFLTQAAGQLGVRLSDFDVRDVAADLEWAKVLQCPPQNYPALARRHGRVSAKPADETAALYDRYEALKSAAHCLDFEDVLLLLVALLETEPEAVRMVRGRYQCFVVDEYQDVNALEQRLLDAWLGSRTEVCVVGDPRQAIYGFAGATDRYLVEFAERYPQATMVSLTRNYRSTQEILAAAHRLAGGTPLIAVRGSGVSPTVVAYPTVEAEAQGVAASVAELISSGVSPDDIAVLVRRHALAEPISAAFDEVGIRSVRIATASRTGVPRTAGAVTIASLHAAKGLEWEVVFLPGWADGILPDARALSVDAVAEEQRLAYVGVTRARRMLVVSYPRSVQRAGERVECEPSRFLAAFAASARPAVGEPSVEPAEKPGGCGAAGGVGAAGPAS
>NC_008578.1|WP_011720607.1|2009132_2009402_+|mycoredoxin
MPDGTTVTIFTTPWCGYCRRLKRELDEQGIPYQEVNIEADPEAADLVARVNGGNQTVPTVLFPDGRTLTNPPASAVIARLADLQATPQR
>NC_008578.1|WP_011720608.1|2009514_2010924_-|dipeptidase
MDREAVRRYLAEQRDAFVAQLGEWLRIPSVWTDPAHADDVRRSAEWLAAVLRSAGFPTVEVWTAPSGAPAVFAEWPAEDPGAPTVVVYGHHDVQPVDPVEAWTFAPFEPAIVDDRILGRGASDDKGQVLCHLLGLQANLAASGRQQPPVTLRLLIEGEEESGSPTFAELLRAHRDRLAPDVIVVSDSAMYAPGVVSVCLGMRGLTDCQIDLHGPDVDLHSGTFGGAVPNPLTVLARLLAGLHDDHGQVTLPGFYDHVRPISAQEREMISRLPFDESTWLAQAASRATYGEDGFSTLERIWTRPTCEIHGIWGGYTGPGHKTIIPTDAHAKVSFRLVADQDPASVQEALRRYVAEHVPAGITATVTFFGPGVRPYLVPADHPAVAATCRALSAAFDGAEVFFTREGGSGPEADIAEILGAPLVFLGIGLPTDRYHAPDEHAHIPMLLKGAEAICYLWDDLAAHRDDVVRR
>NC_008578.1|WP_011720609.1|2011208_2011703_+|universal-stress-protein
MVEQLIATGVDDTAHDVTQTEPEPTATEARRNLVVVGVDGSACSAKALAWAEEYAKTVGADLALVIAWHWPTAYGEPIPFEDFTPEADAAEVLRKAAATLTLPSERVRLVVRQGAAGDVLVKASESARLLVVGCRGHGSLLKRVIGSTSIYCAHHAHCPVVIVR
>NC_008578.1|WP_011720610.1|2011689_2015184_-|ATP-dependent-helicase
MTGATSAGSGAGARPRFRAADLAGLLGLPPPTDEQAAVIESAAPLSVVLAGAGSGKTETMAGRVVYLVANGIVRPEQVLGLTFTRRAATELAGRIRRRLTQLARRRVIDPEVLAVGEPTVVTYDAYAGRIVADHALRLGVEPGLRLIGQAASWQFARRAVDAYDGPMDAVTLSPTTVTNRVFILAGELAQHRVDVESVAEFCDQLAAKLCALPYPRGRSRTMAEDVERIVDQLKLRRQLLPIVVDYRARKRDAEVLDFADQMALAATLAELFPEVGAAERAAFRAVLLDEFQDTSHAQLDFLRALFLPKTAPPDAESPAAAQPWLTVVGDPAQAIYGWRGASHGTFRALIAEAPCAVTVFPLATSFRNSPEILAVANLIAEPLRAGRDTTAVPVLRPRDDAPVGEARCACYPTVEDEAAAVAEYVARVLREDEAARQAGEPGRSIAILLRKWRQLLPLEPALRARGVPIRILGVGGLLDQPEIEDVVATLQVLVDPDRGDALMRLLTGARWRIGAADLAALHRWARRCAAADDRAATESQTLHGPDDRAATESQTSHGPDDAGAPLGGDAADSLSLVDALDRLRTERWVTQSGWFSVEGGRRLARLADELHHLRSRLSQPLPDLVAEVIATIGVDVEVLARGEQPGRSNLDAFLEVAADYADAAENPTLGGFLDYLEAAGYAERGLDRPEDDAAVAFDAAAGERRPGVVDVLTVHAAKGLEWDVVCVPGMVDGVFPTGVRNTTGWLTSAHLLPWPLRGDRDALPSIDMTTADDQSAVVALLKDFAEAVKCHALAEERRLAYVAVTRARRWLFCTGYRWDDTTRAHADSAFLTGDVLGAMRVECWTPVPDDGTANPRLVDGPRRVAWPVDPLGSRRPQVERAAALVRDAVAVAGEPMSGRDDGSAEALTGGEAEPRPRTPIPATQWEQVDGWSRDIAVLLAERSRATEQSAVVLPEQLSVTQLVALREDPSRFAARLRRPLPNRPVPSARRGTAFHRWLEQRFAAPRLLDVDELPGAADSDAAPDDELEALKTAFLESHWASRHPVDVEVPFHLVVDGRVIRGRMDAVFADPDGGFTIVDWKTGRRPRGEYAEAAAVQLGAYRLAWSELSGVPLERVRATFCYLRDGGDYAPADLLDRRGLMELLAARTLPLAGRPRSGSPFSAR
>NC_008578.1|WP_049751483.1|2015283_2018562_-|ATP-dependent-helicase
MVATVADTPGGNRHPGRAAPEWDAEQQAVLAHRGGPLLILGGPGTGKTTLLIETVADRVSRGEVALENVLVLTGQRRSAAELRRRIALRLGRTSREPLARTFHSYAFGVLCADAIQRGEPPPRLLTSAEQDVIIRELLRGDLDRGATGWPERLRPALPTRGFARELREFLQQAVQRGLTPDDVARLGRQAGRDDWVAIGRFAREYSQVTALRDAAGYDPAELILAATALLQEHPQLLESCRVRHALVVVDEYEETDPAQRRLLRAITSGAALVIAADPDQSVYGFRGADPLGVREFLSDFADQRPRVVVLGRAYRGGPALLAAVRRLAERLPVVVPPGVSAAAYRGLAVGAEAGAVRALAGAGAGVAGAGAAAADGDGSVDVRAGAGADGDGSVDVRAFATPGAQAAYIAYHLRHAHLVEGLGWTAMAVLVRSAAQIPPLRRALTAAGVPVRVPEQSSPIVDVPIVRHLLLALRIAAGQPLLDVERAPTAAASLAEELVAGPIGRADPLQLRRLRIALRRLDRAAGGERSSAVVLAQVLNDPRDLEVIDEQAAAPALRVARAIEAGRRAVTEPAATAETVLWEIWNATGLATELYAQALSGGAVGAAADRDLDAVMALFAAASRYVDRLPRAGAALFADYLLGQEIPTDTLAARAPEPDGVDLLTAHAAKSREWDVVVLAGVQEGVWPDLRRRGSLLGLRDFLDVLDGRIADAADRGPGGSIRTLEERSAALAEERRLCYLAASRARRKLIVTAVSGDQEIPSRFLDDIDPLDADERPLTRPPRGLDLPSLLGDLRRAAETADDAVARRAAGHLAQLAAAGIPGAAPDGWYGLPAPSTDQPLRRDDEPVPVSPSRLELFTRCPLRWLLESCGGRGRSSASQVVGTAVHRAAATFSVDVAQLRERLDAALADTDLGTGWFAAAQRDRAAAMVERLAAWMARNPRRLLAVERDFQVTVGRALLTGRVDRLEQDDDGRLYVVDLKTGRRAVRKADLAEHPQLGAYQVAVVEGAFDEGRTPAGAALLFLDEDRPEPVEWGQAPLEAAGGSWAHEMIMKCAEGMAAAVFDAVANDGCRFCPVRICCPLWVEGAAVTG
>NC_008578.1|WP_011720612.1|2018752_2019943_-|adenylyltransferase/sulfurtransferase-MoeZ
MAYPPLVEPADTLTVDEVRRYSRHLIIPDVGMAGQKRLKNAKVLAIGAGGLGSPVLMYLAAAGVGTLGVIDFDTVDESNLQRQVIHGQSDIGRSKAQSARDTIKEINPFVTVVLHEERLDNDNVLDIFSQYDLIVDGTDNFATRYLVNDACVLLGKPYVWGSIYRFDGQVSVFWANAPGGQAPCYRCLYPEPPPPGMVPSCAEGGVLGVLCATVGSIQATEAIKVLTGIGEPLVGRLLVYDALEMTFRTVNVRKDPECPICGKNPTITELIDYEEFCGVASEEAQLAAAGSTISPLELKEWMDRGENIFLVDVREPAEFEIVSIPGATLIPKGEFVMGTALEKLPQNKRIVLYCKTGGRSAEALAIVKAAGFADAVHVGGGVVGWVKQVDPSLPSY

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Crispr_ID: NC_008578_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_14

2007215-2007299

Orphan

Consensus_repeat	Method
GATCGAACCGGTTCGTGGTCGCGCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_14

>merge|NC_008578|14|2007215-2007299|CRISPRCasFinder
GATCGAACCGGTTCGTGGTCGCGCGACCGGTCTTGGCGGCGCCCCTTCTATCACCCAGCGATCGAACCGGTTCGTGGTCGCGCGA

>NC_008578|14|14|2007215-2007299|CRISPRCasFinder
GATCGAACCGGTTCGTGGTCGCGCGA	CCGGTCTTGGCGGCGCCCCTTCTATCACCCAGC
GATCGAACCGGTTCGTGGTCGCGCGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_148204592.1\|2005318_2006665_+\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|270872
NC_008578.1\|WP_011720607.1\|2009132_2009402_+\|mycoredoxin	unknown	unknown	gnl\|CDD\|131255
NC_008578.1\|WP_049751479.1\|1997248_1997959_-\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
NC_008578.1\|WP_011720609.1\|2011208_2011703_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_008578.1\|WP_049751482.1\|2007389_2008922_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_008578.1\|WP_169303206.1\|1998220_1999954_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237447
NC_008578.1\|WP_169303207.1\|2003659_2003818_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_049751483.1\|2015283_2018562_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_008578.1\|WP_011720612.1\|2018752_2019943_-\|adenylyltransferase/sulfurtransferase-MoeZ	unknown	unknown	gnl\|CDD\|181156
NC_008578.1\|WP_011720614.1\|2021120_2021795_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214910
NC_008578.1\|WP_083760570.1\|2002545_2003175_-\|M48-family-metallopeptidase	unknown	unknown	gnl\|CDD\|320703
NC_008578.1\|WP_011720610.1\|2011689_2015184_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_008578.1\|WP_083760646.1\|2019957_2020932_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|184875
NC_008578.1\|WP_011720599.1\|2000028_2001756_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_008578.1\|WP_011720603.1\|2004099_2005278_+\|TOMM-precursor-leader-peptide-binding-protein	unknown	unknown	gnl\|CDD\|238386
NC_008578.1\|WP_041835682.1\|1994884_1995664_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_008578.1\|WP_011720615.1\|2021942_2022581_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NC_008578.1\|WP_041835067.1\|2006767_2007052_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NC_008578.1\|WP_011720600.1\|2001762_2002440_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_008578.1\|WP_011720608.1\|2009514_2010924_-\|dipeptidase	unknown	unknown	gnl\|CDD\|349929

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_148204592.1\|2005318_2006665_+\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|270872	cd13970, ABC1_ADCK3, Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3. This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.	2.9033e-90
NC_008578.1\|WP_011720607.1\|2009132_2009402_+\|mycoredoxin	gnl\|CDD\|131255	TIGR02200, conserved_hypothetical_protein, Glutaredoxin-like protein. This family of glutaredoxin-like proteins is limited to the Actinobacteria and contains the conserved CxxC motif.	1.08004e-30
NC_008578.1\|WP_049751479.1\|1997248_1997959_-\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	6.85475e-33
NC_008578.1\|WP_011720609.1\|2011208_2011703_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.45781e-22
NC_008578.1\|WP_049751482.1\|2007389_2008922_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	8.71152e-86
NC_008578.1\|WP_169303206.1\|1998220_1999954_-\|hypothetical-protein	gnl\|CDD\|237447	PRK13613, PRK13613, lipoprotein LpqB; Provisional.	5.1913e-51
NC_008578.1\|WP_049751483.1\|2015283_2018562_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	3.10788e-72
NC_008578.1\|WP_011720612.1\|2018752_2019943_-\|adenylyltransferase/sulfurtransferase-MoeZ	gnl\|CDD\|181156	PRK07878, PRK07878, molybdopterin biosynthesis-like protein MoeZ; Validated.	0
NC_008578.1\|WP_011720614.1\|2021120_2021795_-\|hypothetical-protein	gnl\|CDD\|214910	smart00917, LeuA_dimer, LeuA allosteric (dimerisation) domain. This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyses the first committed step in the leucine biosynthetic pathway. This domain, is an internally duplicated structure with a novel fold. It comprises two similar units that are arranged such that the two -helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich.	0.000423667
NC_008578.1\|WP_083760570.1\|2002545_2003175_-\|M48-family-metallopeptidase	gnl\|CDD\|320703	cd07344, M48_yhfN_like, Peptidase M48 YhfN-like, a novel minigluzincin. M48 YhfN-like protease is considered as a CaaX prenyl protease 1 homolog, with most of the sequences in this family as yet uncharacterized. It contains the zinc metalloprotease motif (HEXXH), likely exposed on the cytoplasmic side. It is probably associated with the endoplasmic reticulum (ER), regardless of whether its genes possess the conventional signal motif (KKXX) in the C-terminal. Proteins in this family proteolytically remove the C-terminal three residues of farnesylated proteins. This novel family of related proteins consist of the soluble minimal scaffold similar to the catalytic domains of the integral-membrane metallopeptidase M48 and M56, thus called minigluzincins.	1.66472e-18
NC_008578.1\|WP_011720610.1\|2011689_2015184_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	2.70127e-81
NC_008578.1\|WP_083760646.1\|2019957_2020932_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	1.88309e-29
NC_008578.1\|WP_011720599.1\|2000028_2001756_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.43713e-55
NC_008578.1\|WP_011720603.1\|2004099_2005278_+\|TOMM-precursor-leader-peptide-binding-protein	gnl\|CDD\|238386	cd00757, ThiF_MoeB_HesA_family, ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD and ThiS, respectively, on the alpha-phosphate of an ATP molecule bound at the active site of the activating enzymes, leading to the formation of a high-energy acyladenylate intermediate and subsequently to the formation of a thiocarboxylate at the C termini of MoaD and ThiS. MoeB, as the MPT synthase (MoaE/MoaD complex) sulfurase, is involved in the biosynthesis of the molybdenum cofactor, a derivative of the tricyclic pterin, molybdopterin (MPT). ThiF catalyzes the adenylation of ThiS, as part of the biosynthesis pathway of thiamin pyrophosphate (vitamin B1). .	2.17724e-12
NC_008578.1\|WP_041835682.1\|1994884_1995664_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.9756e-81
NC_008578.1\|WP_011720615.1\|2021942_2022581_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	2.42746e-14
NC_008578.1\|WP_041835067.1\|2006767_2007052_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	6.88918e-14
NC_008578.1\|WP_011720600.1\|2001762_2002440_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.44614e-88
NC_008578.1\|WP_011720608.1\|2009514_2010924_-\|dipeptidase	gnl\|CDD\|349929	cd05680, M20_dipept_like, uncharacterized M20 dipeptidase. Peptidase M20 family, unknown dipeptidase-like subfamily (inferred by homology to be dipeptidases). M20 dipeptidases include a large variety of bacterial enzymes including cytosolic nonspecific dipeptidase (CNDP), Xaa-methyl-His dipeptidase (anserinase),and canosinase. These dipeptidases have been shown to act on a wide range of dipeptides, but not larger peptides. For example, anserinase mainly catalyzes the hydrolysis of N-alpha-acetylhistidine while carnosinase degrades beta-alanyl-L-histidine.	0

>NC_008578.1|WP_041835067.1|2006767_2007052_-|WhiB-family-transcriptional-regulator
MSVTDVDAGCAQAIDARREIPCLQVNPEIFFAEDPEDIDVAKALCRRCPRRVACLDDALQRREPWGVWGGELFSGGRVVSQKRPRGRPRKERVV
>NC_008578.1|WP_148204592.1|2005318_2006665_+|AarF/ABC1/UbiB-kinase-family-protein
MADIPRGTVARTARLARLPLSAAGRTAVGIGKRLTGRPAEEVIGEFQRRTAEQLFDVLGELKGGAMKLGQALSVFEAAMPDDLAAPYRESLTRLQENAPPLPAATVHRVLAGQLGPQWRTYFRDFEDRPAAAASIGQVHRAVWQDGRHVAVKIQYPGAGKALLSDLTQLGRLGRVFGVLFPGLDLKPLLQELRARVTEELDYRLEAMSQHAFARAYLDDPDIYVPDVLAGADRVIVSEWIDGTPLSSIIRSGTRRQRDHAGLLLVRFLFSGPARVGMLHADPHPGNYRLLDDGRLAVLDFGAVNRLPGGFPPIIGRLLSLALREEPDAVLEGLREEGFVRARRSVDPHDLLAYLNPFLDPVRYPVFHFTRRWLREQASRIGDPRTPSGALARQLNLPPSYLLIHRVWMGSIGILCQLDAAGPFRAEIERWLPGLELPELVEDAEQSAE
>NC_008578.1|WP_011720603.1|2004099_2005278_+|TOMM-precursor-leader-peptide-binding-protein
MRPRLKPAVRVLWRDAATVQFGVDARSAVAVTGVDPCTAALFDALDGSRTDAELRVLGRQLGLDASSVDRLLDWLRSGRLLDDAARRPAEALLPRGAEDLLTPDLAALSLLSEEPDGGAVLLERRRAARISVVGAGRVGATVATLLAAAGIGRVVPDDPEPATAADCAPGGLAPADAGTPRGDALRRRLLAVNPAVQTAPPTDGDYTLQVLAPPGPFDATVGDAALRGHTPHLLAFVRDLTGVIGPLVSPGRSPCLRCLEAARAARDPRWPLIAAQLASDPPRKRRACDVVLATLVAAIAALQVLAFVDGRRPATVGATVEMTLPDWRFRRRRWSMHPDCGCGWPSNAEPDAGIDPGSGRGIGAAPGGGVGPGRAVGPSVSVGARSGVGMNA
>NC_008578.1|WP_169303207.1|2003659_2003818_+|hypothetical-protein
MAEKYNGEAYCVKCKEKRQFEGDVVVNDKGTKMARGKCPVCGTTLNRILGKA
>NC_008578.1|WP_083760570.1|2002545_2003175_-|M48-family-metallopeptidase
MTASSGSRSRGSQRSYRSTPTPPRRSVSVERVLLDGSTLVEIRRSLRRRRTISAHVDGDHIVVSVPARLSRAEREKWVRIMVERLARRRGRQDAADSDQRLLRRAVQLSRRYLGGRAQPASVRWVANQESRWGSCTPESRSIRLSKRLQVMPSWVRDYVLLHELVHLIDPTHGPRFHALLNQFPWAERAKGYLQGISDAALLRSHRGSA
>NC_008578.1|WP_011720600.1|2001762_2002440_-|response-regulator-transcription-factor
MKGRVLVVDDDTALAEMLGIVLRGEGFEPHFVFDGDKALAAFREVKPDVVLLDLMLPGTDGIDVCRQIRAESGVPIVMLTAKSDTVDVVVGLESGADDYVVKPFKPKELVARLRARLRRTDEPAPEILTIGDVTIDVAGHSVTRDGQPIPLTPLEFDLLVALARKPRHVFSREVLLEQVWGYRHAADTRLVNVHVQRLRSKIEKDPDHPEIVLTVRGVGYKAGPA
>NC_008578.1|WP_011720599.1|2000028_2001756_-|HAMP-domain-containing-histidine-kinase
MAVLDDAAPAPDGRRPPSGDEPAAVHSVPAAWHRRGFPVGRIARAIGHRWRRSIQFRVVATTLLVSAAVVALLGLVVLQQVRAGLLQAKVRSSVNQELIGLASAQQSLTSSANAITALTNTVKSLSPPDTSRRQPGGYEVVAFQVLSPGVVAKNQPAADVDFRVSSIPDDLIAAVSQGQARYYYAYTVMQYTDGFQVPGLAIGSLVTTPSNQQYEIYYVFSLQQEQQTLELVTRTLLVSGLGLVALLAAIAYLVTRQVVKPVRVAAQIAERLADGRLQERMTPKGEDDLARLAASFNKMAESLQRQIRRLEHLSRVQRRFVSDVSHELRTPVTTIRMAADVLFEARHGFDPASARSAELLQNQLDRFESLLADLLEISRHDAGAASLEADVVDVRDLVRHVVEDTEPLAARRGSIVQVIVPAEACLCEADGRRVERILRNLLVNAAEHGEGRPIVVRVAAGEDAVAVAVRDHGIGLRPGEAALVFNRFWRADPARARSTGGTGLGLAIALEDARLHGGTLQAWGEPGKGSQFVLTLPKRVGFPISRPPIPVEPEDAAASPSGAGSASVAAERAVP
>NC_008578.1|WP_169303206.1|1998220_1999954_-|hypothetical-protein
MTVPTGGRVHAGSQASQDSQGGRNIQVPAAYAVEGLSPKDVVGGFRLASAVLSNPAIARSYLADPTWQPTEGVHVIDESGESVVYAINGDTATVRVIDKWVGTIFTDGTYQPQPNGATSDVTYTLTKSAPQSKGEWRISKLPNFLVLDRTEVENAFWQGSLYYLSPGGQFLVPVRVFLPHTATDVATALVEQLSQPVPGWLAHAGVFSALPQTDQAPTVTVSGDVATVDLPPPFGNLNAIERDQASAQLTYTLVRSGVASQVRITVGGAPLPNSRQAVTQTLKTWSAFDPDVLRTATFTYIDDAGVPRLANGAPLLSPPLPEPTATKGTGTAAPGPRPRFVSAVVAPRLVGSSGPDLVAGVTRNPDNTQTLYAGPINAVVPVLSAASFSTPSWDLLGNVWTVEQVSTGAQEILVGVVTPTTTPKFQRVNIDGTLASSLIVSLKVSRDGTRVALVVRSTTGSQLWVGRVERSDRGVTIGGLYPVAPNVQPAADGVAWASATSLAILATSSGSEIVTAWLVDVDGWDATIQQVPFDASSLTAAPNQPLAIGTKSRQVEVLNGSAWQVVVDGGTVPNYPS
>NC_008578.1|WP_049751479.1|1997248_1997959_-|ComF-family-protein
MSWLRAAGRAVAELLVACACPGCGRDAPPGSLCAVCDAAIRAGPLVARQLAEGVPVVAAGGYEGPLRRLLLAYKEHGRRDLRDVLAALLVRNLDFLAATADRIVVVPIPSTRTALRARGWEPVAELARAAAHAAVPPTRVARLLRCRRTVADQAALAATERFVNLAGAYTVSPGMAARFRREQADPPRRTAVLVLDDIVTTGATLGEAVRALRAGGVPVFGAVTVAATRLRRGGTC
>NC_008578.1|WP_041835682.1|1994884_1995664_-|response-regulator-transcription-factor
MRPPYPGGNRAHGANGPAPASGPAPATAPDAPATDATGDVDPIKVLVADDHALFRRGLEMVLRQEPDIQLVAEASDGAEAVARAAETLPDVVLLDVRMPKRTGIEACAAIKEVCPSAKIIMLTISDEEADLYEAIKAGAMGYLLKEISIDEVAAAIRAVHGGQSLISPSMASKLLNEFASLIKRGDARHQVPAPKLTEREMEVLRLVAKGLNNRDIAKQLFISENTVKNHVRNILEKLQLHSRMEAVVYAVREKLLEIT
>NC_008578.1|WP_049751482.1|2007389_2008922_-|ATP-dependent-helicase
MTVSRAVSGVDVLAALDDDQRAAVTAMPGPVGILAGPGTGKTRTIAHRIAHAVQSGQWRPQQVLAVTFTNRAAAELRHRLRMLGVDDVSTGTFHAVALRQLRYFWPRLVGGAFPRIVADKTPFLTQAAGQLGVRLSDFDVRDVAADLEWAKVLQCPPQNYPALARRHGRVSAKPADETAALYDRYEALKSAAHCLDFEDVLLLLVALLETEPEAVRMVRGRYQCFVVDEYQDVNALEQRLLDAWLGSRTEVCVVGDPRQAIYGFAGATDRYLVEFAERYPQATMVSLTRNYRSTQEILAAAHRLAGGTPLIAVRGSGVSPTVVAYPTVEAEAQGVAASVAELISSGVSPDDIAVLVRRHALAEPISAAFDEVGIRSVRIATASRTGVPRTAGAVTIASLHAAKGLEWEVVFLPGWADGILPDARALSVDAVAEEQRLAYVGVTRARRMLVVSYPRSVQRAGERVECEPSRFLAAFAASARPAVGEPSVEPAEKPGGCGAAGGVGAAGPAS
>NC_008578.1|WP_011720607.1|2009132_2009402_+|mycoredoxin
MPDGTTVTIFTTPWCGYCRRLKRELDEQGIPYQEVNIEADPEAADLVARVNGGNQTVPTVLFPDGRTLTNPPASAVIARLADLQATPQR
>NC_008578.1|WP_011720608.1|2009514_2010924_-|dipeptidase
MDREAVRRYLAEQRDAFVAQLGEWLRIPSVWTDPAHADDVRRSAEWLAAVLRSAGFPTVEVWTAPSGAPAVFAEWPAEDPGAPTVVVYGHHDVQPVDPVEAWTFAPFEPAIVDDRILGRGASDDKGQVLCHLLGLQANLAASGRQQPPVTLRLLIEGEEESGSPTFAELLRAHRDRLAPDVIVVSDSAMYAPGVVSVCLGMRGLTDCQIDLHGPDVDLHSGTFGGAVPNPLTVLARLLAGLHDDHGQVTLPGFYDHVRPISAQEREMISRLPFDESTWLAQAASRATYGEDGFSTLERIWTRPTCEIHGIWGGYTGPGHKTIIPTDAHAKVSFRLVADQDPASVQEALRRYVAEHVPAGITATVTFFGPGVRPYLVPADHPAVAATCRALSAAFDGAEVFFTREGGSGPEADIAEILGAPLVFLGIGLPTDRYHAPDEHAHIPMLLKGAEAICYLWDDLAAHRDDVVRR
>NC_008578.1|WP_011720609.1|2011208_2011703_+|universal-stress-protein
MVEQLIATGVDDTAHDVTQTEPEPTATEARRNLVVVGVDGSACSAKALAWAEEYAKTVGADLALVIAWHWPTAYGEPIPFEDFTPEADAAEVLRKAAATLTLPSERVRLVVRQGAAGDVLVKASESARLLVVGCRGHGSLLKRVIGSTSIYCAHHAHCPVVIVR
>NC_008578.1|WP_011720610.1|2011689_2015184_-|ATP-dependent-helicase
MTGATSAGSGAGARPRFRAADLAGLLGLPPPTDEQAAVIESAAPLSVVLAGAGSGKTETMAGRVVYLVANGIVRPEQVLGLTFTRRAATELAGRIRRRLTQLARRRVIDPEVLAVGEPTVVTYDAYAGRIVADHALRLGVEPGLRLIGQAASWQFARRAVDAYDGPMDAVTLSPTTVTNRVFILAGELAQHRVDVESVAEFCDQLAAKLCALPYPRGRSRTMAEDVERIVDQLKLRRQLLPIVVDYRARKRDAEVLDFADQMALAATLAELFPEVGAAERAAFRAVLLDEFQDTSHAQLDFLRALFLPKTAPPDAESPAAAQPWLTVVGDPAQAIYGWRGASHGTFRALIAEAPCAVTVFPLATSFRNSPEILAVANLIAEPLRAGRDTTAVPVLRPRDDAPVGEARCACYPTVEDEAAAVAEYVARVLREDEAARQAGEPGRSIAILLRKWRQLLPLEPALRARGVPIRILGVGGLLDQPEIEDVVATLQVLVDPDRGDALMRLLTGARWRIGAADLAALHRWARRCAAADDRAATESQTLHGPDDRAATESQTSHGPDDAGAPLGGDAADSLSLVDALDRLRTERWVTQSGWFSVEGGRRLARLADELHHLRSRLSQPLPDLVAEVIATIGVDVEVLARGEQPGRSNLDAFLEVAADYADAAENPTLGGFLDYLEAAGYAERGLDRPEDDAAVAFDAAAGERRPGVVDVLTVHAAKGLEWDVVCVPGMVDGVFPTGVRNTTGWLTSAHLLPWPLRGDRDALPSIDMTTADDQSAVVALLKDFAEAVKCHALAEERRLAYVAVTRARRWLFCTGYRWDDTTRAHADSAFLTGDVLGAMRVECWTPVPDDGTANPRLVDGPRRVAWPVDPLGSRRPQVERAAALVRDAVAVAGEPMSGRDDGSAEALTGGEAEPRPRTPIPATQWEQVDGWSRDIAVLLAERSRATEQSAVVLPEQLSVTQLVALREDPSRFAARLRRPLPNRPVPSARRGTAFHRWLEQRFAAPRLLDVDELPGAADSDAAPDDELEALKTAFLESHWASRHPVDVEVPFHLVVDGRVIRGRMDAVFADPDGGFTIVDWKTGRRPRGEYAEAAAVQLGAYRLAWSELSGVPLERVRATFCYLRDGGDYAPADLLDRRGLMELLAARTLPLAGRPRSGSPFSAR
>NC_008578.1|WP_049751483.1|2015283_2018562_-|ATP-dependent-helicase
MVATVADTPGGNRHPGRAAPEWDAEQQAVLAHRGGPLLILGGPGTGKTTLLIETVADRVSRGEVALENVLVLTGQRRSAAELRRRIALRLGRTSREPLARTFHSYAFGVLCADAIQRGEPPPRLLTSAEQDVIIRELLRGDLDRGATGWPERLRPALPTRGFARELREFLQQAVQRGLTPDDVARLGRQAGRDDWVAIGRFAREYSQVTALRDAAGYDPAELILAATALLQEHPQLLESCRVRHALVVVDEYEETDPAQRRLLRAITSGAALVIAADPDQSVYGFRGADPLGVREFLSDFADQRPRVVVLGRAYRGGPALLAAVRRLAERLPVVVPPGVSAAAYRGLAVGAEAGAVRALAGAGAGVAGAGAAAADGDGSVDVRAGAGADGDGSVDVRAFATPGAQAAYIAYHLRHAHLVEGLGWTAMAVLVRSAAQIPPLRRALTAAGVPVRVPEQSSPIVDVPIVRHLLLALRIAAGQPLLDVERAPTAAASLAEELVAGPIGRADPLQLRRLRIALRRLDRAAGGERSSAVVLAQVLNDPRDLEVIDEQAAAPALRVARAIEAGRRAVTEPAATAETVLWEIWNATGLATELYAQALSGGAVGAAADRDLDAVMALFAAASRYVDRLPRAGAALFADYLLGQEIPTDTLAARAPEPDGVDLLTAHAAKSREWDVVVLAGVQEGVWPDLRRRGSLLGLRDFLDVLDGRIADAADRGPGGSIRTLEERSAALAEERRLCYLAASRARRKLIVTAVSGDQEIPSRFLDDIDPLDADERPLTRPPRGLDLPSLLGDLRRAAETADDAVARRAAGHLAQLAAAGIPGAAPDGWYGLPAPSTDQPLRRDDEPVPVSPSRLELFTRCPLRWLLESCGGRGRSSASQVVGTAVHRAAATFSVDVAQLRERLDAALADTDLGTGWFAAAQRDRAAAMVERLAAWMARNPRRLLAVERDFQVTVGRALLTGRVDRLEQDDDGRLYVVDLKTGRRAVRKADLAEHPQLGAYQVAVVEGAFDEGRTPAGAALLFLDEDRPEPVEWGQAPLEAAGGSWAHEMIMKCAEGMAAAVFDAVANDGCRFCPVRICCPLWVEGAAVTG
>NC_008578.1|WP_011720612.1|2018752_2019943_-|adenylyltransferase/sulfurtransferase-MoeZ
MAYPPLVEPADTLTVDEVRRYSRHLIIPDVGMAGQKRLKNAKVLAIGAGGLGSPVLMYLAAAGVGTLGVIDFDTVDESNLQRQVIHGQSDIGRSKAQSARDTIKEINPFVTVVLHEERLDNDNVLDIFSQYDLIVDGTDNFATRYLVNDACVLLGKPYVWGSIYRFDGQVSVFWANAPGGQAPCYRCLYPEPPPPGMVPSCAEGGVLGVLCATVGSIQATEAIKVLTGIGEPLVGRLLVYDALEMTFRTVNVRKDPECPICGKNPTITELIDYEEFCGVASEEAQLAAAGSTISPLELKEWMDRGENIFLVDVREPAEFEIVSIPGATLIPKGEFVMGTALEKLPQNKRIVLYCKTGGRSAEALAIVKAAGFADAVHVGGGVVGWVKQVDPSLPSY
>NC_008578.1|WP_083760646.1|2019957_2020932_-|alpha/beta-fold-hydrolase
MLFVRRAGPVDRVAGSAESPRAPLLFVHGLGGDSLDWAELAGVLRAHDPTQALIAIDLPGFGFSLPPADGDFSLDAHGRAIAGCIEALDCGPVHLVANSMGGSIATRLAARRPELFTSLTLISPALPDPLPPRGSWQLLPAALPAIGPRLVSAGLRVDPEWVVHHAIRLCFGNPNRIDDTRRRLLFDIVRRRAGTAHGVDAYCASLRSLIASYGRRRLWADAAAVDVPTLLVYGGRDRLVSPRSAYRALRAFPHARLVFLPDAGHVPHLEAPEVVAGALMAFFRGAPVVAGTGRPAPPAGMVAAHATVDVGATGPTLRDERTVS
>NC_008578.1|WP_011720614.1|2021120_2021795_-|hypothetical-protein
MSVTDHREIVAALRELPGVADAEVQPDTAGDGLGVLRLGLEPGVDEVEVASAVGRLLRERFGLGVDAERVQLVEDMEAGDEEPSEAPQPTQAADGRFRPAIRRMHIVSSGLSVAADVTLAVGDRTVVGHADGTATRSGVQRAVATATLRAVEELLGGQARFELDLVEVAPTGRDRTVLVAVTMLTGNGSERLTGAAAIREDVRQAAIRATLDALNRRVEHLLAG
>NC_008578.1|WP_011720615.1|2021942_2022581_-|methyltransferase-domain-containing-protein
MRGAVFDAFADRYDRWYDRDPGRAWFAAEVEALRPFVEPTVHPRLEVGSGSGRFTAALDIDIGIDPAWQPLQLARCRGVRVLRGVAERLPFRGHVFGVVVFVVTLCFVDDLDRVFAETRRVLRPGAPIVIGVIFAEGPLGRAYRAATELGNPFYAKARFLTWPDLRSALSRAGFAVDGVRSILATHRQGDWRPVEVRDGLAKEAAFVALSAR

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Crispr_ID: NC_008578_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_15

2018628-2018730

Orphan

Consensus_repeat	Method
CCCTGCGGTTCGGTGACGGGCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_15

>merge|NC_008578|15|2018628-2018730|CRISPRCasFinder
CCCTGCGGTTCGGTGACGGGCCTTTGCGCCCGGTCCCCCTGCGGTTCGGTGACGGGCCTCCAGGCCCGGGCTAGCGGTCCCCCTGCGGTTCGGTGACGGGCCT

>NC_008578|15|15|2018628-2018730|CRISPRCasFinder
CCCTGCGGTTCGGTGACGGGCCT	TTGCGCCCGGTCCCCCTGCGGTTCGGTGACGGGCCTCCAGGCCCGGGCTAGCGGTCC
CCCTGCGGTTCGGTGACGGGCCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_148204695.1\|2023053_2024616_+\|cytochrome-b-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379304
NC_008578.1\|WP_148204592.1\|2005318_2006665_+\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|270872
NC_008578.1\|WP_011720607.1\|2009132_2009402_+\|mycoredoxin	unknown	unknown	gnl\|CDD\|131255
NC_008578.1\|WP_011720619.1\|2025298_2025973_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|205967
NC_008578.1\|WP_011720610.1\|2011689_2015184_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_008578.1\|WP_148204593.1\|2026087_2026528_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_049751482.1\|2007389_2008922_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_008578.1\|WP_169303207.1\|2003659_2003818_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720612.1\|2018752_2019943_-\|adenylyltransferase/sulfurtransferase-MoeZ	unknown	unknown	gnl\|CDD\|181156
NC_008578.1\|WP_049751483.1\|2015283_2018562_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_008578.1\|WP_011720614.1\|2021120_2021795_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214910
NC_008578.1\|WP_011720618.1\|2025013_2025238_+\|DUF3107-domain-containing-protein	unknown	unknown	gnl\|CDD\|378634
NC_008578.1\|WP_011720617.1\|2024761_2024977_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_083760646.1\|2019957_2020932_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|184875
NC_008578.1\|WP_011720603.1\|2004099_2005278_+\|TOMM-precursor-leader-peptide-binding-protein	unknown	unknown	gnl\|CDD\|238386
NC_008578.1\|WP_011720615.1\|2021942_2022581_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NC_008578.1\|WP_011720608.1\|2009514_2010924_-\|dipeptidase	unknown	unknown	gnl\|CDD\|349929
NC_008578.1\|WP_011720620.1\|2026705_2027068_-\|response-regulator	unknown	unknown	gnl\|CDD\|381150
NC_008578.1\|WP_041835067.1\|2006767_2007052_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NC_008578.1\|WP_011720609.1\|2011208_2011703_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_148204695.1\|2023053_2024616_+\|cytochrome-b-N-terminal-domain-containing-protein	gnl\|CDD\|379304	pfam13631, Cytochrom_B_N_2, Cytochrome b(N-terminal)/b6/petB.	2.26666e-11
NC_008578.1\|WP_148204592.1\|2005318_2006665_+\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|270872	cd13970, ABC1_ADCK3, Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3. This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.	2.9033e-90
NC_008578.1\|WP_011720607.1\|2009132_2009402_+\|mycoredoxin	gnl\|CDD\|131255	TIGR02200, conserved_hypothetical_protein, Glutaredoxin-like protein. This family of glutaredoxin-like proteins is limited to the Actinobacteria and contains the conserved CxxC motif.	1.08004e-30
NC_008578.1\|WP_011720619.1\|2025298_2025973_-\|hypothetical-protein	gnl\|CDD\|205967	pfam13794, MiaE_2, tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like.	6.49604e-63
NC_008578.1\|WP_011720610.1\|2011689_2015184_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	2.70127e-81
NC_008578.1\|WP_049751482.1\|2007389_2008922_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	8.71152e-86
NC_008578.1\|WP_011720612.1\|2018752_2019943_-\|adenylyltransferase/sulfurtransferase-MoeZ	gnl\|CDD\|181156	PRK07878, PRK07878, molybdopterin biosynthesis-like protein MoeZ; Validated.	0
NC_008578.1\|WP_049751483.1\|2015283_2018562_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	3.10788e-72
NC_008578.1\|WP_011720614.1\|2021120_2021795_-\|hypothetical-protein	gnl\|CDD\|214910	smart00917, LeuA_dimer, LeuA allosteric (dimerisation) domain. This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyses the first committed step in the leucine biosynthetic pathway. This domain, is an internally duplicated structure with a novel fold. It comprises two similar units that are arranged such that the two -helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich.	0.000423667
NC_008578.1\|WP_011720618.1\|2025013_2025238_+\|DUF3107-domain-containing-protein	gnl\|CDD\|378634	pfam11305, DUF3107, Protein of unknown function (DUF3107). Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.	8.75775e-33
NC_008578.1\|WP_011720603.1\|2004099_2005278_+\|TOMM-precursor-leader-peptide-binding-protein	gnl\|CDD\|238386	cd00757, ThiF_MoeB_HesA_family, ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD and ThiS, respectively, on the alpha-phosphate of an ATP molecule bound at the active site of the activating enzymes, leading to the formation of a high-energy acyladenylate intermediate and subsequently to the formation of a thiocarboxylate at the C termini of MoaD and ThiS. MoeB, as the MPT synthase (MoaE/MoaD complex) sulfurase, is involved in the biosynthesis of the molybdenum cofactor, a derivative of the tricyclic pterin, molybdopterin (MPT). ThiF catalyzes the adenylation of ThiS, as part of the biosynthesis pathway of thiamin pyrophosphate (vitamin B1). .	2.17724e-12
NC_008578.1\|WP_011720615.1\|2021942_2022581_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	2.42746e-14
NC_008578.1\|WP_011720608.1\|2009514_2010924_-\|dipeptidase	gnl\|CDD\|349929	cd05680, M20_dipept_like, uncharacterized M20 dipeptidase. Peptidase M20 family, unknown dipeptidase-like subfamily (inferred by homology to be dipeptidases). M20 dipeptidases include a large variety of bacterial enzymes including cytosolic nonspecific dipeptidase (CNDP), Xaa-methyl-His dipeptidase (anserinase),and canosinase. These dipeptidases have been shown to act on a wide range of dipeptides, but not larger peptides. For example, anserinase mainly catalyzes the hydrolysis of N-alpha-acetylhistidine while carnosinase degrades beta-alanyl-L-histidine.	0
NC_008578.1\|WP_011720620.1\|2026705_2027068_-\|response-regulator	gnl\|CDD\|381150	cd19923, REC_CheY_CheY3, phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins. CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	5.24728e-30
NC_008578.1\|WP_083760646.1\|2019957_2020932_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	1.88309e-29
NC_008578.1\|WP_041835067.1\|2006767_2007052_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	6.88918e-14
NC_008578.1\|WP_011720609.1\|2011208_2011703_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.45781e-22

>NC_008578.1|WP_049751483.1|2015283_2018562_-|ATP-dependent-helicase
MVATVADTPGGNRHPGRAAPEWDAEQQAVLAHRGGPLLILGGPGTGKTTLLIETVADRVSRGEVALENVLVLTGQRRSAAELRRRIALRLGRTSREPLARTFHSYAFGVLCADAIQRGEPPPRLLTSAEQDVIIRELLRGDLDRGATGWPERLRPALPTRGFARELREFLQQAVQRGLTPDDVARLGRQAGRDDWVAIGRFAREYSQVTALRDAAGYDPAELILAATALLQEHPQLLESCRVRHALVVVDEYEETDPAQRRLLRAITSGAALVIAADPDQSVYGFRGADPLGVREFLSDFADQRPRVVVLGRAYRGGPALLAAVRRLAERLPVVVPPGVSAAAYRGLAVGAEAGAVRALAGAGAGVAGAGAAAADGDGSVDVRAGAGADGDGSVDVRAFATPGAQAAYIAYHLRHAHLVEGLGWTAMAVLVRSAAQIPPLRRALTAAGVPVRVPEQSSPIVDVPIVRHLLLALRIAAGQPLLDVERAPTAAASLAEELVAGPIGRADPLQLRRLRIALRRLDRAAGGERSSAVVLAQVLNDPRDLEVIDEQAAAPALRVARAIEAGRRAVTEPAATAETVLWEIWNATGLATELYAQALSGGAVGAAADRDLDAVMALFAAASRYVDRLPRAGAALFADYLLGQEIPTDTLAARAPEPDGVDLLTAHAAKSREWDVVVLAGVQEGVWPDLRRRGSLLGLRDFLDVLDGRIADAADRGPGGSIRTLEERSAALAEERRLCYLAASRARRKLIVTAVSGDQEIPSRFLDDIDPLDADERPLTRPPRGLDLPSLLGDLRRAAETADDAVARRAAGHLAQLAAAGIPGAAPDGWYGLPAPSTDQPLRRDDEPVPVSPSRLELFTRCPLRWLLESCGGRGRSSASQVVGTAVHRAAATFSVDVAQLRERLDAALADTDLGTGWFAAAQRDRAAAMVERLAAWMARNPRRLLAVERDFQVTVGRALLTGRVDRLEQDDDGRLYVVDLKTGRRAVRKADLAEHPQLGAYQVAVVEGAFDEGRTPAGAALLFLDEDRPEPVEWGQAPLEAAGGSWAHEMIMKCAEGMAAAVFDAVANDGCRFCPVRICCPLWVEGAAVTG
>NC_008578.1|WP_011720610.1|2011689_2015184_-|ATP-dependent-helicase
MTGATSAGSGAGARPRFRAADLAGLLGLPPPTDEQAAVIESAAPLSVVLAGAGSGKTETMAGRVVYLVANGIVRPEQVLGLTFTRRAATELAGRIRRRLTQLARRRVIDPEVLAVGEPTVVTYDAYAGRIVADHALRLGVEPGLRLIGQAASWQFARRAVDAYDGPMDAVTLSPTTVTNRVFILAGELAQHRVDVESVAEFCDQLAAKLCALPYPRGRSRTMAEDVERIVDQLKLRRQLLPIVVDYRARKRDAEVLDFADQMALAATLAELFPEVGAAERAAFRAVLLDEFQDTSHAQLDFLRALFLPKTAPPDAESPAAAQPWLTVVGDPAQAIYGWRGASHGTFRALIAEAPCAVTVFPLATSFRNSPEILAVANLIAEPLRAGRDTTAVPVLRPRDDAPVGEARCACYPTVEDEAAAVAEYVARVLREDEAARQAGEPGRSIAILLRKWRQLLPLEPALRARGVPIRILGVGGLLDQPEIEDVVATLQVLVDPDRGDALMRLLTGARWRIGAADLAALHRWARRCAAADDRAATESQTLHGPDDRAATESQTSHGPDDAGAPLGGDAADSLSLVDALDRLRTERWVTQSGWFSVEGGRRLARLADELHHLRSRLSQPLPDLVAEVIATIGVDVEVLARGEQPGRSNLDAFLEVAADYADAAENPTLGGFLDYLEAAGYAERGLDRPEDDAAVAFDAAAGERRPGVVDVLTVHAAKGLEWDVVCVPGMVDGVFPTGVRNTTGWLTSAHLLPWPLRGDRDALPSIDMTTADDQSAVVALLKDFAEAVKCHALAEERRLAYVAVTRARRWLFCTGYRWDDTTRAHADSAFLTGDVLGAMRVECWTPVPDDGTANPRLVDGPRRVAWPVDPLGSRRPQVERAAALVRDAVAVAGEPMSGRDDGSAEALTGGEAEPRPRTPIPATQWEQVDGWSRDIAVLLAERSRATEQSAVVLPEQLSVTQLVALREDPSRFAARLRRPLPNRPVPSARRGTAFHRWLEQRFAAPRLLDVDELPGAADSDAAPDDELEALKTAFLESHWASRHPVDVEVPFHLVVDGRVIRGRMDAVFADPDGGFTIVDWKTGRRPRGEYAEAAAVQLGAYRLAWSELSGVPLERVRATFCYLRDGGDYAPADLLDRRGLMELLAARTLPLAGRPRSGSPFSAR
>NC_008578.1|WP_011720609.1|2011208_2011703_+|universal-stress-protein
MVEQLIATGVDDTAHDVTQTEPEPTATEARRNLVVVGVDGSACSAKALAWAEEYAKTVGADLALVIAWHWPTAYGEPIPFEDFTPEADAAEVLRKAAATLTLPSERVRLVVRQGAAGDVLVKASESARLLVVGCRGHGSLLKRVIGSTSIYCAHHAHCPVVIVR
>NC_008578.1|WP_011720608.1|2009514_2010924_-|dipeptidase
MDREAVRRYLAEQRDAFVAQLGEWLRIPSVWTDPAHADDVRRSAEWLAAVLRSAGFPTVEVWTAPSGAPAVFAEWPAEDPGAPTVVVYGHHDVQPVDPVEAWTFAPFEPAIVDDRILGRGASDDKGQVLCHLLGLQANLAASGRQQPPVTLRLLIEGEEESGSPTFAELLRAHRDRLAPDVIVVSDSAMYAPGVVSVCLGMRGLTDCQIDLHGPDVDLHSGTFGGAVPNPLTVLARLLAGLHDDHGQVTLPGFYDHVRPISAQEREMISRLPFDESTWLAQAASRATYGEDGFSTLERIWTRPTCEIHGIWGGYTGPGHKTIIPTDAHAKVSFRLVADQDPASVQEALRRYVAEHVPAGITATVTFFGPGVRPYLVPADHPAVAATCRALSAAFDGAEVFFTREGGSGPEADIAEILGAPLVFLGIGLPTDRYHAPDEHAHIPMLLKGAEAICYLWDDLAAHRDDVVRR
>NC_008578.1|WP_011720607.1|2009132_2009402_+|mycoredoxin
MPDGTTVTIFTTPWCGYCRRLKRELDEQGIPYQEVNIEADPEAADLVARVNGGNQTVPTVLFPDGRTLTNPPASAVIARLADLQATPQR
>NC_008578.1|WP_049751482.1|2007389_2008922_-|ATP-dependent-helicase
MTVSRAVSGVDVLAALDDDQRAAVTAMPGPVGILAGPGTGKTRTIAHRIAHAVQSGQWRPQQVLAVTFTNRAAAELRHRLRMLGVDDVSTGTFHAVALRQLRYFWPRLVGGAFPRIVADKTPFLTQAAGQLGVRLSDFDVRDVAADLEWAKVLQCPPQNYPALARRHGRVSAKPADETAALYDRYEALKSAAHCLDFEDVLLLLVALLETEPEAVRMVRGRYQCFVVDEYQDVNALEQRLLDAWLGSRTEVCVVGDPRQAIYGFAGATDRYLVEFAERYPQATMVSLTRNYRSTQEILAAAHRLAGGTPLIAVRGSGVSPTVVAYPTVEAEAQGVAASVAELISSGVSPDDIAVLVRRHALAEPISAAFDEVGIRSVRIATASRTGVPRTAGAVTIASLHAAKGLEWEVVFLPGWADGILPDARALSVDAVAEEQRLAYVGVTRARRMLVVSYPRSVQRAGERVECEPSRFLAAFAASARPAVGEPSVEPAEKPGGCGAAGGVGAAGPAS
>NC_008578.1|WP_041835067.1|2006767_2007052_-|WhiB-family-transcriptional-regulator
MSVTDVDAGCAQAIDARREIPCLQVNPEIFFAEDPEDIDVAKALCRRCPRRVACLDDALQRREPWGVWGGELFSGGRVVSQKRPRGRPRKERVV
>NC_008578.1|WP_148204592.1|2005318_2006665_+|AarF/ABC1/UbiB-kinase-family-protein
MADIPRGTVARTARLARLPLSAAGRTAVGIGKRLTGRPAEEVIGEFQRRTAEQLFDVLGELKGGAMKLGQALSVFEAAMPDDLAAPYRESLTRLQENAPPLPAATVHRVLAGQLGPQWRTYFRDFEDRPAAAASIGQVHRAVWQDGRHVAVKIQYPGAGKALLSDLTQLGRLGRVFGVLFPGLDLKPLLQELRARVTEELDYRLEAMSQHAFARAYLDDPDIYVPDVLAGADRVIVSEWIDGTPLSSIIRSGTRRQRDHAGLLLVRFLFSGPARVGMLHADPHPGNYRLLDDGRLAVLDFGAVNRLPGGFPPIIGRLLSLALREEPDAVLEGLREEGFVRARRSVDPHDLLAYLNPFLDPVRYPVFHFTRRWLREQASRIGDPRTPSGALARQLNLPPSYLLIHRVWMGSIGILCQLDAAGPFRAEIERWLPGLELPELVEDAEQSAE
>NC_008578.1|WP_011720603.1|2004099_2005278_+|TOMM-precursor-leader-peptide-binding-protein
MRPRLKPAVRVLWRDAATVQFGVDARSAVAVTGVDPCTAALFDALDGSRTDAELRVLGRQLGLDASSVDRLLDWLRSGRLLDDAARRPAEALLPRGAEDLLTPDLAALSLLSEEPDGGAVLLERRRAARISVVGAGRVGATVATLLAAAGIGRVVPDDPEPATAADCAPGGLAPADAGTPRGDALRRRLLAVNPAVQTAPPTDGDYTLQVLAPPGPFDATVGDAALRGHTPHLLAFVRDLTGVIGPLVSPGRSPCLRCLEAARAARDPRWPLIAAQLASDPPRKRRACDVVLATLVAAIAALQVLAFVDGRRPATVGATVEMTLPDWRFRRRRWSMHPDCGCGWPSNAEPDAGIDPGSGRGIGAAPGGGVGPGRAVGPSVSVGARSGVGMNA
>NC_008578.1|WP_169303207.1|2003659_2003818_+|hypothetical-protein
MAEKYNGEAYCVKCKEKRQFEGDVVVNDKGTKMARGKCPVCGTTLNRILGKA
>NC_008578.1|WP_011720612.1|2018752_2019943_-|adenylyltransferase/sulfurtransferase-MoeZ
MAYPPLVEPADTLTVDEVRRYSRHLIIPDVGMAGQKRLKNAKVLAIGAGGLGSPVLMYLAAAGVGTLGVIDFDTVDESNLQRQVIHGQSDIGRSKAQSARDTIKEINPFVTVVLHEERLDNDNVLDIFSQYDLIVDGTDNFATRYLVNDACVLLGKPYVWGSIYRFDGQVSVFWANAPGGQAPCYRCLYPEPPPPGMVPSCAEGGVLGVLCATVGSIQATEAIKVLTGIGEPLVGRLLVYDALEMTFRTVNVRKDPECPICGKNPTITELIDYEEFCGVASEEAQLAAAGSTISPLELKEWMDRGENIFLVDVREPAEFEIVSIPGATLIPKGEFVMGTALEKLPQNKRIVLYCKTGGRSAEALAIVKAAGFADAVHVGGGVVGWVKQVDPSLPSY
>NC_008578.1|WP_083760646.1|2019957_2020932_-|alpha/beta-fold-hydrolase
MLFVRRAGPVDRVAGSAESPRAPLLFVHGLGGDSLDWAELAGVLRAHDPTQALIAIDLPGFGFSLPPADGDFSLDAHGRAIAGCIEALDCGPVHLVANSMGGSIATRLAARRPELFTSLTLISPALPDPLPPRGSWQLLPAALPAIGPRLVSAGLRVDPEWVVHHAIRLCFGNPNRIDDTRRRLLFDIVRRRAGTAHGVDAYCASLRSLIASYGRRRLWADAAAVDVPTLLVYGGRDRLVSPRSAYRALRAFPHARLVFLPDAGHVPHLEAPEVVAGALMAFFRGAPVVAGTGRPAPPAGMVAAHATVDVGATGPTLRDERTVS
>NC_008578.1|WP_011720614.1|2021120_2021795_-|hypothetical-protein
MSVTDHREIVAALRELPGVADAEVQPDTAGDGLGVLRLGLEPGVDEVEVASAVGRLLRERFGLGVDAERVQLVEDMEAGDEEPSEAPQPTQAADGRFRPAIRRMHIVSSGLSVAADVTLAVGDRTVVGHADGTATRSGVQRAVATATLRAVEELLGGQARFELDLVEVAPTGRDRTVLVAVTMLTGNGSERLTGAAAIREDVRQAAIRATLDALNRRVEHLLAG
>NC_008578.1|WP_011720615.1|2021942_2022581_-|methyltransferase-domain-containing-protein
MRGAVFDAFADRYDRWYDRDPGRAWFAAEVEALRPFVEPTVHPRLEVGSGSGRFTAALDIDIGIDPAWQPLQLARCRGVRVLRGVAERLPFRGHVFGVVVFVVTLCFVDDLDRVFAETRRVLRPGAPIVIGVIFAEGPLGRAYRAATELGNPFYAKARFLTWPDLRSALSRAGFAVDGVRSILATHRQGDWRPVEVRDGLAKEAAFVALSAR
>NC_008578.1|WP_148204695.1|2023053_2024616_+|cytochrome-b-N-terminal-domain-containing-protein
MWTARLRRRLLATLPPKKLLPDRQPIYVASWVYVFGVATLAALGLAIFSGALIALGGTDWWHTNPVGHFFNSLHLWSVELFMAFMVIHLWGKFWMAAWRGRRSLTWITGVVAFLASIVECFTGYLSQQNFDSQWIATNGKDAFNAVGVGAFWNVMNFGQMLTWHVVLMPLILVALVGFHVILVRVRGVSKPLPENRTAAPKDRRARRAARADDAAPWRGPTRRYDILKEGAIATAVTTALVIIFAGVLSSPDVPPVTVQNWAKLAPADFLATAAGELDGSALAASYGPPYNDGDAAVQQVGPFNWQKLAGITHPIDAAQVFVLSPLEKLAPTNATLAHALAVYDHASPEQRNAWASAYDKAVTKVTFTNGQPVVPPADDGPVPVLMASELTMARSGALDSALLAQNQFYGTDYTKPLLFIADGNYYADLAASMHLTGDQWGVMNETGNYPGQPWLWFYALWYHVHPFSTSPNVDIWAVYLTGIGTLLLLLVPFIPGLRDIPRWIPVHRLIWRRNRLGPVG
>NC_008578.1|WP_011720617.1|2024761_2024977_+|hypothetical-protein
MAGRPLPPDPSVPAEVPEADAAEQQTEAARDSEETGEAAPVVPRITRKRWEADAVDPDDERVVVLDEDDYR
>NC_008578.1|WP_011720618.1|2025013_2025238_+|DUF3107-domain-containing-protein
MEVKIGVQSVARELTLESNQNADEIESAVASALSTGGLLRLVDEKGRRVLVPTDKLAYVEIGEPVERRVGFGAM
>NC_008578.1|WP_011720619.1|2025298_2025973_-|hypothetical-protein
MSSTGMHESADDAEYRAAVADILGVLAYGELMAFERLAYDARMAPTLDDKAALGRLATAEFEHFAALATRLSDLGIPASAAIEPFVEPLEEFHARTAPSDWAESLIKAYVGDGLMRDFYREVTRVLDAETRVVVEKALADTEHVTFLAERLRRIMAEDPRCAGRLALWARRIVGEALLQARLVATRREALVRLLAGGRGVDLSAAFDRIIQAHAGRMAAIGLAA
>NC_008578.1|WP_148204593.1|2026087_2026528_+|hypothetical-protein
MALRTVAGHQIGEDTNDLQQWLRQLTGCPTVHRTIPATCDAPSHDEPATWFYVEADPVQAVARRRCLSCGATRHVLDSEERWTAPHMWQCPGCAQSIAEVATGLHLDDDHVTWIAVAARCVGCGLIAGLTDFIVPRLPFDEVLTRI
>NC_008578.1|WP_011720620.1|2026705_2027068_-|response-regulator
MRILVVDDSRAMRRIIERMLVLAGYDHHDIVHAADAVEATRLMAEQPPDLILCDWNMPGTNGLEFLTAIRRAGWTTPFGFITSEASPAMREQALAAGALFLIAKPFTPEEFHAALDPVLA

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Crispr_ID: NC_008578_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_16

2120249-2120331

Orphan

Consensus_repeat	Method
CCGGCTCGCTGGGACGCCGGTCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_16

>merge|NC_008578|16|2120249-2120331|CRISPRCasFinder
CCGGCTCGCTGGGACGCCGGTCGGCTGAGCCGAAAAGCGCATCGGCTGAGCCGAGACGCCGACTCGCTGGGACGCCGGTCGGC

>NC_008578|16|16|2120249-2120331|CRISPRCasFinder
CCGGCTCGCTGGGACGCCGGTCGGC	TGAGCCGAAAAGCGCATCGGCTGAGCCGAGACG
CCGACTCGCTGGGACGCCGGTCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_148204602.1\|2105963_2106425_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239517
NC_008578.1\|WP_011720711.1\|2121720_2122011_+\|exodeoxyribonuclease-VII-small-subunit	unknown	unknown	gnl\|CDD\|179195
NC_008578.1\|WP_169303210.1\|2127447_2129601_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_008578.1\|WP_011720705.1\|2113650_2114178_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235095
NC_008578.1\|WP_011720706.1\|2114185_2114743_+\|purine-binding-chemotaxis-protein-CheW	unknown	unknown	gnl\|CDD\|223905
NC_008578.1\|WP_049751654.1\|2110291_2110516_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226657
NC_008578.1\|WP_011720707.1\|2114870_2116538_+\|methyl-accepting-chemotaxis-sensory-transducer	unknown	unknown	gnl\|CDD\|214599
NC_008578.1\|WP_011720708.1\|2116545_2119065_+\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|223716
NC_008578.1\|WP_148204700.1\|2126380_2127214_-\|isoprenyl-transferase	unknown	unknown	gnl\|CDD\|237825
NC_008578.1\|WP_011720710.1\|2120473_2121724_+\|exodeoxyribonuclease-VII-large-subunit	unknown	unknown	gnl\|CDD\|272979
NC_008578.1\|WP_011720703.1\|2110570_2111449_+\|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	unknown	unknown	gnl\|CDD\|274584
NC_008578.1\|WP_011720714.1\|2123939_2125358_+\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NC_008578.1\|WP_011720712.1\|2122000_2123050_+\|class-II-fructose-bisphosphatase	unknown	unknown	gnl\|CDD\|236536
NC_008578.1\|WP_011720715.1\|2125392_2125983_-\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|366654
NC_008578.1\|WP_049751655.1\|2131748_2132216_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|223427
NC_008578.1\|WP_011720718.1\|2129726_2131703_-\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|224250
NC_008578.1\|WP_011720700.1\|2107203_2109000_-\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|236101
NC_008578.1\|WP_011720701.1\|2109067_2109895_-\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720713.1\|2123206_2123497_+\|HesB/YadR/YfhF-family-protein	unknown	unknown	gnl\|CDD\|223393
NC_008578.1\|WP_011720699.1\|2106421_2107204_-\|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|237086

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_148204602.1\|2105963_2106425_+\|NUDIX-domain-containing-protein	gnl\|CDD\|239517	cd03425, MutT_pyrophosphohydrolase, The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). This enzyme requires two divalent cations for activity; one coordinates the phosphoryl groups of the NTP/dNTP substrate, and the other coordinates to the enzyme. It also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as metal binding and catalytic site. MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides.	3.44424e-38
NC_008578.1\|WP_011720712.1\|2122000_2123050_+\|class-II-fructose-bisphosphatase	gnl\|CDD\|236536	PRK09479, glpX, fructose 1,6-bisphosphatase II; Reviewed.	0
NC_008578.1\|WP_169303210.1\|2127447_2129601_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.74481e-38
NC_008578.1\|WP_011720705.1\|2113650_2114178_+\|hypothetical-protein	gnl\|CDD\|235095	PRK02983, lysS, bifunctional lysylphosphatidylglycerol synthetase/lysine--tRNA ligase LysX.	0.000277021
NC_008578.1\|WP_011720706.1\|2114185_2114743_+\|purine-binding-chemotaxis-protein-CheW	gnl\|CDD\|223905	COG0835, CheW, Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms].	4.58888e-28
NC_008578.1\|WP_049751654.1\|2110291_2110516_+\|hypothetical-protein	gnl\|CDD\|226657	COG4194, COG4194, Predicted membrane protein [General function prediction only].	0.000194211
NC_008578.1\|WP_011720707.1\|2114870_2116538_+\|methyl-accepting-chemotaxis-sensory-transducer	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	5.36501e-64
NC_008578.1\|WP_011720708.1\|2116545_2119065_+\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|223716	COG0643, CheA, Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms].	1.22535e-134
NC_008578.1\|WP_148204700.1\|2126380_2127214_-\|isoprenyl-transferase	gnl\|CDD\|237825	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional.	1.62471e-135
NC_008578.1\|WP_011720710.1\|2120473_2121724_+\|exodeoxyribonuclease-VII-large-subunit	gnl\|CDD\|272979	TIGR00237, exodeoxyribonuclease_VII_large_subunit, exodeoxyribonuclease VII, large subunit. This family consist of exodeoxyribonuclease VII, large subunit XseA which catalyses exonucleolytic cleavage in either the 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. Exonuclease VII consists of one large subunit and four small subunits. [DNA metabolism, Degradation of DNA].	1.46965e-163
NC_008578.1\|WP_011720703.1\|2110570_2111449_+\|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	gnl\|CDD\|274584	TIGR03445, mycothiol_MshB, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase. Members of this protein family are N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase, also called 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, the MshB protein of mycothiol biosynthesis in Mycobacterium tuberculosis and related species. [Cellular processes, Detoxification].	1.87388e-122
NC_008578.1\|WP_011720714.1\|2123939_2125358_+\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NC_008578.1\|WP_011720715.1\|2125392_2125983_-\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|366654	pfam01464, SLT, Transglycosylase SLT domain. This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.	0.00267874
NC_008578.1\|WP_049751655.1\|2131748_2132216_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	7.47974e-48
NC_008578.1\|WP_011720718.1\|2129726_2131703_-\|thioredoxin-domain-containing-protein	gnl\|CDD\|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NC_008578.1\|WP_011720700.1\|2107203_2109000_-\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|236101	PRK07803, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
NC_008578.1\|WP_011720711.1\|2121720_2122011_+\|exodeoxyribonuclease-VII-small-subunit	gnl\|CDD\|179195	PRK00977, PRK00977, exodeoxyribonuclease VII small subunit; Provisional.	1.26851e-19
NC_008578.1\|WP_011720713.1\|2123206_2123497_+\|HesB/YadR/YfhF-family-protein	gnl\|CDD\|223393	COG0316, sufA, Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones].	2.64329e-10
NC_008578.1\|WP_011720699.1\|2106421_2107204_-\|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	gnl\|CDD\|237086	PRK12386, PRK12386, fumarate reductase iron-sulfur subunit; Provisional.	0

>NC_008578.1|WP_011720708.1|2116545_2119065_+|hybrid-sensor-histidine-kinase/response-regulator
MGGWAEDPELLATFRAEVEERLASLSAGLLRLETGAASRQVLSALFRDAHTVKGSARMMGLTAVLETAHAAEDLLAALRDGRFPVRRDLVDLLLATVDGISRSLPGDPAPVGEEHLRALIAALRSALDGEEPVTVPRLPEPTVTVQSGPQPLAVPPPPARPGTTPSATETPAPAAQAAAPPFAVPPPPDGQAAGPPLAVPPPPAGPTGSPAGSTARPPRPAGSAPPPAGSAPVGRPSTPTATLSTPAAAASTLLESITPPAAVQIGGPTEPERGFDAIRVASRRVYDLLDVVGEAELDARRVERNAIELETLLTEQQRWLRAVRAAATQPSEDLELALHRLVATSDQLVASGHQLRERVEDARSRLAQVRDGAMGLAMVPVRRVLSGFPRLVRDVASAGGKDVGLRLVGEDVELDKKVLDAIADALRHLVTNAVDHGCETPAERVAAGKPPRATVTVEARSAGGTVVLEVADDGRGIDESAVRRQAIERGLLPPDSTVSGPALLQVLFAPAFSTAPTVTVTSGRGVGLDVVRTVVDELGGTIDIYTEPGRGTRFVLTLPITLGVLRCLIARVGAERYAVPVPNVIESISLRDVPVDNLAGAPVVVRHGTSVPLLDLGAALGVEGVRDPRAALVVRQGGGDLVAWSVDRLEGELELVVKDLGSFIGRLPLVTGATIDGDGTVVCLLDLREMSARTGAASTAQPATAPPELETPRPLGRRPRILVVEDSVGVRELERVILEGAGYEVTTAVDGLDGLARLRTELPDLVLADVEMPGMDGFTLTRTIRRTRGWEHLPVVIMTSRGDDGDRRAGMEAGANAYLLKSEFDQAQLVETVGRLLGR
>NC_008578.1|WP_011720707.1|2114870_2116538_+|methyl-accepting-chemotaxis-sensory-transducer
MDVVKRLQQVSAICTGLMLALGIAGVLAVGSHPTPGVDIRPAVVAGWLGVAVLGATLVTVACLARVDHPALGPTGAVADLGRLVYLAGITGALVAAAGFATPLWILYIPVLLTTAVSDAPWKSFGYAFLAAVLALTATAATHHLDRSTALTTLLAIPAIPAVVWFASTLAHSVTNLRQRLDEERRRMHDELERTRAELLDEARAERENLQDEIRRERAELKAKVERLSEALAAAARGDLSAYQQIDLGPPTGEDDEALAVLQAAFANTLGSLRHLVEQIRASGESISAAAGQLLATAEEHAASATQQSSAVAETTSTIEELAATAAQIAETAEAVARYAAETLRYAEEGREAVAASVAAMDTIANRVDSIASRALSLGEKSQEIGRILEVIDDLADQTNLLALNAAIEAARAGEHGRGFAVVASEVRKLAERSQESAAKIQGIVSEIQAETNATILATEEGAKEVHAGTELARGVVEALERISGMVDETTTAAKEISIATQQQRSASDQVVTAMMQVSDVSRQYVVGSKQAAASAAQLNVLAAELRASIAQFRIS
>NC_008578.1|WP_011720706.1|2114185_2114743_+|purine-binding-chemotaxis-protein-CheW
MRDSETTTGTAATEARRAAGPAAADGGTGGGPRLADVEEAGYVLARLGGGRYAIEMSAVAEVGRVPWITRVPGTPVWLAGVANWRGRILAVVDLRPLLGTEMPPVGSLGRLVVITDGTVTAGLLTEGVHGVIHCPADQLDPPPRTVDPDVAALLLGQFTPDHGPVAVINPAALLGLRRKLPNVRT
>NC_008578.1|WP_011720705.1|2113650_2114178_+|hypothetical-protein
MPPSAPQPDRRWTWLTAGIGVLLGLVTGLLTAVQATRVVDGVPVGALAAFGANFGGGVLIGWGLRAREAAALPAFGWLLAVFLLIALPRPGGDVLLPGSGAPVVAFLLGGIAGSPASIFVAAALLRRQAKAANSGSRSQLPSAAPTASRPDDIDRPGAAARDTTDGASPNSRTSR
>NC_008578.1|WP_011720703.1|2110570_2111449_+|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase
MVRSLLLVHAHPDDESISTGATMAYYAAQGVRVTLVTCTLGEEGEILVPDLRLLAADEADQLGGYRISELAAACAALGVTDHRFLGGAGRYRDSGMMGTPANNHPRAFWQADLDTAAAYLVDIIRDVRPQVVITYDENGGYGHPDHIQAHRVTVRAVDQTRDIVTKLYAAAVPRSAFAEGIQALRAAGDTTSFAGVEDVDNVPFVRPDEVITTAIDARAFLDRKIAALRAHATQIAVDGPFFALSNNIGQRAFGVEYYILLRGTAYPAGDGRENDLFAGVDVVQAGDVGAAT
>NC_008578.1|WP_049751654.1|2110291_2110516_+|hypothetical-protein
MLIAAVVRELRRPKAERRWVGQLGPIPYDLRTPTPQRLLRSVWSPEDPRILVPRAFGVGWSINFAALRRRAARH
>NC_008578.1|WP_011720701.1|2109067_2109895_-|hypothetical-protein
MTVESRVPAPAPARTGRRAAIGVATLRTDRWWAQPAFTFGVLMSFIIYSTWAAFVDRDYFWEPYLSPFYSPCIATRCGMVPGSAGAPHVGIFGSWWIISPAVIILIVPLGFRLTCYYYRKAYYRAFWLAPPACAVAEPHARYTGETRFPLILQNVHRYFFYLGFLLNIILSYDAVIAFRDHSGRWGHAGLGTLVLVLNALLLWGYTLSCHSCRNIVGGRLNHFSKHPLRYRFWTLVSRMNRYHGQIAWVSLVWVALADLYVRLVAAGWITDVRFF
>NC_008578.1|WP_011720700.1|2107203_2109000_-|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit
MTEIERHQYDVVIVGAGGAGLRAAIGAHDKGARTAVVCKSLLGKAHTVMAEGGIAAAMGNVWPEDNWQVHFRDTMRGGKMLNNWRMAQLHAQEAPERVWELESWGALFDRTPDGKISQRDFGGHRYARLAHVGDRTGLEMIRTLQQRVVALGIDVFMECTITRLLLDGDRIAGAFGYWRESGRFIVFEAPAVVLATGGIGKSFKVTSNSWEYTGDGHAMAMAAGAPLINMEFVQFHPTGMLWPPSVRGILVTESVRGDGGVLRNAAGRRFMFDYISDYFKAETADTEEEADRWYDDHINNRRPPELLPRDEVARAINAEVKAGRGSPHGGVYLDIASRRSPEFIKKRLPSMYHQFKELADVDITKEPMEIAPTCHYVMGGVEVDADSAMSKVPGLFAAGEVAGGMHGANRLGGNSLSDLLVFGKRAGEYAAEYARGQASRPRIDEADIRDAEQEALAPFMRDGGENPYTLQRELQETMHSLVGIIRVADEMKQALEKIAEYRERLARVSVEGNRQYNPGWHLALDLRNMLMVSESIARAALERKESRGGHTRDDYPASDPEWGKRNVCCRWAGDHVEVYQQPLPEMPDELKKLFEENH
>NC_008578.1|WP_011720699.1|2106421_2107204_-|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit
MGYDLKLRVWRGDENGGRLVDFTVPVEEGEVVLDAIHRLQATQAGDLAVRWNCKAGKCGSCSAEINGKPRLMCMTRLSLFDPQETITVTPMRTFPVIRDLVTDVSFNYEKAKSVPPFTPPADLAPGEYRMQQVDVERSQEFRKCIECFLCQDVCHVIRDHEENKPRFAGPRFFIRYAELDMHPLDTLDRKQQLREEHGIGFCNITKCCTEVCPEGIKITDNAIIPMKERVVDTHYDPVTRLFRKVRSPEQPRRPAARDAG
>NC_008578.1|WP_148204602.1|2105963_2106425_+|NUDIX-domain-containing-protein
MRGRARAVAPALATTAGRLQSVTSIIVGAAIIQEGRLLAACRADPPELAGWWELPGGKVEDGEEEADAIRRECREELDVDVAPLHRLGEWPIDADRRLRVWTARLRDGAPRAVTHREVRWLAAEELYSVAWLPADLPVIGVLDAQLRNGRRGP
>NC_008578.1|WP_011720710.1|2120473_2121724_+|exodeoxyribonuclease-VII-large-subunit
MALTSSAESPVPVREVARQIGLWVGRLGRIWVDGQLTQIKIRPGTNTVFFNLRDPSANVTLLATCPRQVFECIEPKPTEGLRVAVLGKPEFYVPRGSLQLVVHDIRPIGIGDLLARLERLKKILAAEGLFAPERKRPLPFLPRVVGLICGRGSAAERDVVENARRRWPAVRFDIAAVAVQGPYAVPEIVAALRRLDDDPVVDVIVIARGGGSVEDLLPFSDETLLRAVAACRTPVVSAIGHETDTPLLDFVADVAASTPTDAARRIVPDVAEQYAQLAQLGDRLRNALRHRIDREQQVLDTLRSRPVLAHPVQDINRRGEEILRLVRAGRTALDTAIRAADADARHLVARLRALAPAATLERGYAIVLDPAGRVIRGADEVQTGDELVVRLGRGRLRVTVTDVAPAETDHPLGSLA
>NC_008578.1|WP_011720711.1|2121720_2122011_+|exodeoxyribonuclease-VII-small-subunit
MTEPPLPHESADDGRARLSYEDARDELIQIVQRLELGGLPLEEALRLWERGEELARVCQAWLDGARARLEAYRAPEQSAANDVSAPGSAEEHDHGR
>NC_008578.1|WP_011720712.1|2122000_2123050_+|class-II-fructose-bisphosphatase
MADNDVERQPEAPDRNLALELVRVTEAAAMAAGRWVGRGDKDAADHAAVEAMRRLIGTVSMRGVVVIGEGEKDHAPMLYNGEHVGDGTGPECDVAVDPIDGTRLTAMGMNNAISVLAVADRHSMYDPSAVFYMQKLVTGAVAAPYVDINAPVSANIRAVAAAKGCANQDVTVVVLDRPRHADLVREIRETGARIKFIMDGDVAGAIMAAREDTGVDLLLGIGGTPEGIIAACAVKCLGGVIQGKLWPRDEEERRKALDAGHDLDRVLTNDDLVRSDNVFFCATGITDGELLRGVRYRGGGAQTSSLVMRSKSGTIRMIHSEHRLSKLRSYAIVDYDQRPVASSDRIQLR
>NC_008578.1|WP_011720713.1|2123206_2123497_+|HesB/YadR/YfhF-family-protein
MLTLTDNAAAVVRTLTQQIAGETGGLRFSRQPGMDETLTIRAAAAPEPGDQVVEQDGARVFLTEEAAAALDDQILDAVVDAGGSVHFSVAPQQPSA
>NC_008578.1|WP_011720714.1|2123939_2125358_+|class-II-fumarate-hydratase
MTAGALGDAFRVEHDSMGEVRVPAHAKWRAQTQRAVENFPISGMRIDRELIAALAAIKGAAARVNAELGVIDPDVASAIAEAAEEVRHGQWDDHFPVDVFQTGSGTSSNMNANEVIATLAAERLGRPIHPNDHVNASQSSNDTFPSAIHIAACRAVTGTLLPALEHLAAALERKATEFADVVKAGRTHLMDATPVTLGQEFSGYSAAVRYGMERLRSVLPRLGELPLGGTAVGTGINTPPGFAARVIERLASQLQLPLTEARNHFEAQGARDALVETSGMLRVVAVSLYKIANDLRLMASGPRTGLAEIHLPDLQPGSSIMPGKVNPVIPEAVCQVAAQVIGNDATVAFGGAAGTLELNVMLPVIARNLLESIRLLSNVARLFADRCVAGITADVERCRRYAESSPAIVTPLNRYIGYEAAAKVAKYALEHDTTIRQAVIDCGFVANGQISEAQLDRVLDVLAMTGRPVTAD
>NC_008578.1|WP_011720715.1|2125392_2125983_-|transglycosylase-SLT-domain-containing-protein
MFRISTRPPAAVCGFAGTMASLAVLAAAVKIPASAGTVASAGASQAATTTGTTVAPQPTPFIGTSTPFVARSVLQPPSRSETRPASPSATASPAVLPENPRDIAQYLAAQRGWTGWEWTCLDELWRRESNYETTATNPASGAYGIPQALPAEKMASAGPDWRTDPVTQITWGLDYIASRYGEPCTAWRYWLRAGSY
>NC_008578.1|WP_148204700.1|2126380_2127214_-|isoprenyl-transferase
MERRCPRVLSLSGGSLPRELEVGNVGLRRLLYGLYERRLAATLPPDRIPRHVGVILDGNRRWGRAMGLGASGGHRRGAEKIEEFLGWCADLRIEVVTLWLLSTDNLARPADELVPLLRIIEETVAELAASRRWRLHPVGALDLLPDQTARTLKEAEHATQDVDGLLVNVAVGYGGRREIADAVRALLHEHAIRGTSIEDLANVLDVEHIARHLYTKGQPDPDLVIRTSGEQRLSGFLLWQSAHSELFFCEALWPDFRRVDFLRAVRAYAQRERRFGA
>NC_008578.1|WP_169303210.1|2127447_2129601_-|SpoIIE-family-protein-phosphatase
MTDPDSPPDKGGQESSHDDTVGDEATTAARPASPEDVDAHLVIDSLVDAVLVVAPDGRIVLANSAAEKLLGAEPGSLSGAPLLDFVPQRYQRAHCAGFERYVRTGEGRLPAGQAVDVAARRRDGVEIPVEIRFGRAGKPTPEGFSVVGVLREVTERIRLERAALLSRYLQAVVEAAPDGVIAWSPDLTILAVNRRFTEMCRLPSEAIPVGGDVVELLQRYGSLLREPQRLLDAFEYARRNPTEAQSLELTLADGRIVETYGAPITDESGTLLGRVWYVHDATERRAAEAHRDRLLRELAAVQRAQQFLLDASTVLARVSGFSESLHALAAAAVPALGDICIVDVLVDDGRRIERVAAVHADPTAQPLVDDLRRRFPPRLDGDNPAAQVLRDGVSRWAAEMSDDFLRATTRNEEHYQLVRALGYTSFITVPMIADGQVLGSITLVSTNSHRRFTDEDVKLAEELARRAALVVAKERRYDAERRLSHNLQASLLPSDLPVFPGVDYAVCFQPGTRDAEVGGDFWDVTTMPDGEVAIMVGDVAGHDMQAAAMMAQLRAACRAIRAETRGPDELVARLHAHWDQLGLARMASAVFARLRPWSGLLRVASAGHPPPLIVEDGRPWFVPIEPSTPFGAPGGGASLWQGTLSPGAVAVFYTDGLVEDRHRDIDDGMARLAVVVTEHWTEPASAIADHVISALLGPERADDVAVLVLRWLGPICS
>NC_008578.1|WP_011720718.1|2129726_2131703_-|thioredoxin-domain-containing-protein
MANRLATATSPYLLQHKDNPVEWWPWCEEAFAEARRRNVPILLSIGYSSCHWCHVMAHESFEDPATAAFMNEHFVCVKVDREERPDIDAVYMEATQAMTGRGGWPLTCFLTPDGEPFFTGTYFPKEPRAGMPAFRQVLEAVWTAWQSRSADLVAAARRVVAVLQQGSRLTDDLGAIDADLLDAAVGELRRQYDPVHGGFGSAPKFPSATTLEFLLRYGSLGAMEMVAVTCEHMARGGIYDQLAGGFHRYSVDAAWTVPHFEKMLYDNAQLLGVYLHWWRRTQHQLARRIVEEVAEFLLRDLCTPAGGFAAALDADAGGVEGGTYVWTLAELRDALGSDDAAYAAELFGVTEHGNTEDGRSVLQLAVDAPDLERWRRIRQRLLAVRSRRAQPARDDKIIASWNGLAVASLAEAGFLLDRDALVDAAVRSAEYLIDVHLRDGRLCRSSRDGERNPVDGALDDYANVAQGLLTLAQIRSEARYLELAGALLEAILTHFRAEDGGFYDTADDAERLVRRPRTFTDDATPSGNSAAAHALLTYAALTGSQRHRDAVPGALRPTVRLARRYPHAVGYGLATIAAWLDGPAEIAVVGDGSLWRTAWLVDRPGAVRAARAADGPPWAPLLEGRTAPPGQSLAYVCRNFECQRPVASEAELRALLES
>NC_008578.1|WP_049751655.1|2131748_2132216_-|methylated-DNA--[protein]-cysteine-S-methyltransferase
MLLVGDGSSDGLALCGAYFIGQRHSVPVDPSWRNEPDAFSEAVVQLTEYFGGERCVFTVPLRWHGTPFQETVWRELLGIPYGATWSYRDLAEKVGHGGKARAVAAAVGRNRLAVFVPCHRVIGADGSLAGYAAGVDRKRWLLEHEGALPRGTDTF

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Crispr_ID: NC_008578_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_17

2208609-2210116

TypeII

Consensus_repeat	Method
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CRISPRCasFinder
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CRT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	PILER-CR

23 spacers

cas2,cas1,cas9

The CRISPR arrays of NC_008578_17

>merge|NC_008578|17|2208609-2210116|CRISPRCasFinder,CRT,PILER-CR
TGTTTAAAGCCTGTCTCAATCCCCCGGCTAAAATGGGCGTACCGCGGAAACAGCTATCGCGCATGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGCAGGCTTGACGGGCTCTGCTCGCGGGAAGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGAAAGCACGGCGGGCTGCCGGCCTCACCCGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGCGCGTCAGCCGCGGCACGATTACCGTACGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGATCTGGCCGAGTGCTCGTGGTCACGACGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGCGACCAACGGAAGATCGCCGATATGATAGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGCAATCATCCCACGGCTGCGCACCCCACGGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGATCGGCTTGGTGCGGACCGGCGGGTTTTGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGGCAGATTGATGCTAAAGCTGGGGAGATTGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGGCAGATTGATGCTAAAGCTGGGGAGATTGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGCTCCGGGTGGTATTCCCGCCGGGACCTGGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGCCAACCGCGTACATGGTCGAGGTTTGCAGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGGAAACTGTGAAAAACGGTGCCTTTGCCAGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGTCCGCACCGTCGACTCGTACGCCTGCAGGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGAGATCCTTGAGTGCGTGCCCGGTGCCGCGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGCGCCCGCGCCGCCTGAGCTGGTCGAATTGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGTGCTCGAGCACCGGTAGCAGCTGTGTCTGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGGATCCCACACCCAGCACCAGAACGCGCGGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGCCACCCGGCCACCGTAGCGCGCGGCGGAGGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGTCCATGTCAATTCAGTGGTGGCCGACCTGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGCCGACCGAGCGAAACGCCCGGTGCGAGAGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGTTGATGGCGTGCGATATTCCCCGGTGCGGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGGAGCGGGACTTGAACCCGCGACCAGCGGAGCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG

>NC_008578|17|17|2208609-2210116|CRISPRCasFinder
TGTTTAAAGCCTGTCTCAATCCCCCGGCTAAAATGG	GCGTACCGCGGAAACAGCTATCGCGCAT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CAGGCTTGACGGGCTCTGCTCGCGGGAA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	AAAGCACGGCGGGCTGCCGGCCTCACCC
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CGCGTCAGCCGCGGCACGATTACCGTAC
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	ATCTGGCCGAGTGCTCGTGGTCACGAC
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CGACCAACGGAAGATCGCCGATATGATA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CAATCATCCCACGGCTGCGCACCCCACG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	ATCGGCTTGGTGCGGACCGGCGGGTTTT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	GCAGATTGATGCTAAAGCTGGGGAGATT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	GCAGATTGATGCTAAAGCTGGGGAGATT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CTCCGGGTGGTATTCCCGCCGGGACCTG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CCAACCGCGTACATGGTCGAGGTTTGCA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	GAAACTGTGAAAAACGGTGCCTTTGCCA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	TCCGCACCGTCGACTCGTACGCCTGCAG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	AGATCCTTGAGTGCGTGCCCGGTGCCGC
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CGCCCGCGCCGCCTGAGCTGGTCGAATT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	TGCTCGAGCACCGGTAGCAGCTGTGTCT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	GATCCCACACCCAGCACCAGAACGCGCG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CCACCCGGCCACCGTAGCGCGCGGCGGAG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	TCCATGTCAATTCAGTGGTGGCCGACCT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CCGACCGAGCGAAACGCCCGGTGCGAGA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	TTGATGGCGTGCGATATTCCCCGGTGCG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	AGCGGGACTTGAACCCGCGACCAGCGGA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG

>NC_008578|17|1|2208609-2210116|CRT
TGTTTAAAGCCTGTCTCAATCCCCCGGCTAAAATGG	GCGTACCGCGGAAACAGCTATCGCGCAT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CAGGCTTGACGGGCTCTGCTCGCGGGAA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	AAAGCACGGCGGGCTGCCGGCCTCACCC
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CGCGTCAGCCGCGGCACGATTACCGTAC
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	ATCTGGCCGAGTGCTCGTGGTCACGAC
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CGACCAACGGAAGATCGCCGATATGATA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CAATCATCCCACGGCTGCGCACCCCACG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	ATCGGCTTGGTGCGGACCGGCGGGTTTT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	GCAGATTGATGCTAAAGCTGGGGAGATT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	GCAGATTGATGCTAAAGCTGGGGAGATT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CTCCGGGTGGTATTCCCGCCGGGACCTG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CCAACCGCGTACATGGTCGAGGTTTGCA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	GAAACTGTGAAAAACGGTGCCTTTGCCA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	TCCGCACCGTCGACTCGTACGCCTGCAG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	AGATCCTTGAGTGCGTGCCCGGTGCCGC
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CGCCCGCGCCGCCTGAGCTGGTCGAATT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	TGCTCGAGCACCGGTAGCAGCTGTGTCT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	GATCCCACACCCAGCACCAGAACGCGCG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CCACCCGGCCACCGTAGCGCGCGGCGGAG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	TCCATGTCAATTCAGTGGTGGCCGACCT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CCGACCGAGCGAAACGCCCGGTGCGAGA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	TTGATGGCGTGCGATATTCCCCGGTGCG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	AGCGGGACTTGAACCCGCGACCAGCGGA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG

>NC_008578|17|1|2208673-2210116|PILER-CR
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CAGGCTTGACGGGCTCTGCTCGCGGGAA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	AAAGCACGGCGGGCTGCCGGCCTCACCC
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CGCGTCAGCCGCGGCACGATTACCGTAC
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	ATCTGGCCGAGTGCTCGTGGTCACGAC
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CGACCAACGGAAGATCGCCGATATGATA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CAATCATCCCACGGCTGCGCACCCCACG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	ATCGGCTTGGTGCGGACCGGCGGGTTTT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	GCAGATTGATGCTAAAGCTGGGGAGATT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	GCAGATTGATGCTAAAGCTGGGGAGATT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CTCCGGGTGGTATTCCCGCCGGGACCTG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CCAACCGCGTACATGGTCGAGGTTTGCA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	GAAACTGTGAAAAACGGTGCCTTTGCCA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	TCCGCACCGTCGACTCGTACGCCTGCAG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	AGATCCTTGAGTGCGTGCCCGGTGCCGC
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CGCCCGCGCCGCCTGAGCTGGTCGAATT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	TGCTCGAGCACCGGTAGCAGCTGTGTCT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	GATCCCACACCCAGCACCAGAACGCGCG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CCACCCGGCCACCGTAGCGCGCGGCGGAG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	TCCATGTCAATTCAGTGGTGGCCGACCT
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	CCGACCGAGCGAAACGCCCGGTGCGAGA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	TTGATGGCGTGCGATATTCCCCGGTGCG
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG	AGCGGGACTTGAACCCGCGACCAGCGGA
GCTGGGGAGCCTGTCTCAATCCCCCGGCTAAAATGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_011720783.1\|2207054_2208095_-\|pirin-family-protein	unknown	unknown	gnl\|CDD\|224655
NC_008578.1\|WP_011720782.1\|2204964_2206482_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl\|CDD\|184641
NC_008578.1\|WP_011720779.1\|2202462_2203053_-\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|376485
NC_008578.1\|WP_148204610.1\|2201586_2202429_+\|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl\|CDD\|225002
NC_008578.1\|WP_011720777.1\|2200677_2201541_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133061
NC_008578.1\|WP_011720793.1\|2223967_2224744_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NC_008578.1\|WP_011720774.1\|2196922_2198413_-\|sugar-transferase	unknown	unknown	gnl\|CDD\|274398
NC_008578.1\|WP_011720785.1\|2210482_2211370_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NC_008578.1\|WP_011720784.1\|2210163_2210490_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NC_008578.1\|WP_011720775.1\|2198848_2199424_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|100048
NC_008578.1\|WP_041835088.1\|2211366_2214840_-\|HNH-endonuclease	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|375896
NC_008578.1\|WP_148204704.1\|2218370_2220059_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NC_008578.1\|WP_011720780.1\|2203068_2203680_-\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	unknown	unknown	gnl\|CDD\|235534
NC_008578.1\|WP_011720791.1\|2221021_2222395_-\|NADP-dependent-succinic-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|181826
NC_008578.1\|WP_011720781.1\|2203928_2204906_-\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|179535
NC_008578.1\|WP_011720776.1\|2199420_2200659_-\|L-2-hydroxyglutarate-oxidase	unknown	unknown	gnl\|CDD\|183292
NC_008578.1\|WP_011720790.1\|2220055_2220979_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|283340
NC_008578.1\|WP_011720792.1\|2222585_2223509_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NC_008578.1\|WP_011720787.1\|2215153_2216782_-\|DUF885-domain-containing-protein	unknown	unknown	gnl\|CDD\|377577
NC_008578.1\|WP_011720788.1\|2216841_2218401_+\|trehalose-6-phosphate-synthase	unknown	unknown	gnl\|CDD\|340820

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_011720783.1\|2207054_2208095_-\|pirin-family-protein	gnl\|CDD\|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	4.39477e-67
NC_008578.1\|WP_011720782.1\|2204964_2206482_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl\|CDD\|184641	PRK14352, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NC_008578.1\|WP_011720779.1\|2202462_2203053_-\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|376485	pfam01195, Pept_tRNA_hydro, Peptidyl-tRNA hydrolase.	1.39461e-87
NC_008578.1\|WP_148204610.1\|2201586_2202429_+\|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl\|CDD\|225002	COG2091, Sfp, Phosphopantetheinyl transferase [Coenzyme metabolism].	1.83919e-22
NC_008578.1\|WP_011720777.1\|2200677_2201541_-\|glycosyltransferase	gnl\|CDD\|133061	cd06439, CESA_like_1, CESA_like_1 is a member of the cellulose synthase (CESA) superfamily. This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.	1.86286e-20
NC_008578.1\|WP_011720793.1\|2223967_2224744_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	4.52967e-11
NC_008578.1\|WP_011720774.1\|2196922_2198413_-\|sugar-transferase	gnl\|CDD\|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	1.42138e-137
NC_008578.1\|WP_011720785.1\|2210482_2211370_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	4.10543e-80
NC_008578.1\|WP_011720784.1\|2210163_2210490_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	3.95549e-13
NC_008578.1\|WP_011720775.1\|2198848_2199424_-\|N-acetyltransferase	gnl\|CDD\|100048	cd03358, LbH_WxcM_N_like, WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization and transacetylation reactions of keto-hexoses. It contains an N-terminal LbH domain responsible for the transacetylation function and a C-terminal isomerase domain. The LbH domain contains imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), typical of enzymes with acyltransferase activity.	2.29441e-60
NC_008578.1\|WP_041835088.1\|2211366_2214840_-\|HNH-endonuclease	gnl\|CDD\|375896	pfam18470, Cas9_a, Cas9 alpha-helical lobe domain. This is an alpha-helical lobe domain found in Cas9 proteins. Cas9 enzymes adopt a bilobed architecture composed of a nuclease lobe containing juxtaposed RuvC and HNH nuclease domains and a variable alpha-helical lobe likely to be involved in nucleic acid binding. Amino acid residues located in both the nuclease and alpha-helical lobe clefts are highly conserved within type II-A Cas9 proteins.	3.34074e-54
NC_008578.1\|WP_148204704.1\|2218370_2220059_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	2.6366e-82
NC_008578.1\|WP_011720780.1\|2203068_2203680_-\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	gnl\|CDD\|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	3.51051e-67
NC_008578.1\|WP_011720791.1\|2221021_2222395_-\|NADP-dependent-succinic-semialdehyde-dehydrogenase	gnl\|CDD\|181826	PRK09406, gabD1, succinic semialdehyde dehydrogenase; Reviewed.	0
NC_008578.1\|WP_011720781.1\|2203928_2204906_-\|ribose-phosphate-diphosphokinase	gnl\|CDD\|179535	PRK03092, PRK03092, ribose-phosphate diphosphokinase.	0
NC_008578.1\|WP_011720776.1\|2199420_2200659_-\|L-2-hydroxyglutarate-oxidase	gnl\|CDD\|183292	PRK11728, PRK11728, L-2-hydroxyglutarate oxidase.	0
NC_008578.1\|WP_011720790.1\|2220055_2220979_+\|DMT-family-transporter	gnl\|CDD\|283340	pfam05653, Mg_trans_NIPA, Magnesium transporter NIPA. NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.	0.000101505
NC_008578.1\|WP_011720792.1\|2222585_2223509_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	2.21675e-22
NC_008578.1\|WP_011720787.1\|2215153_2216782_-\|DUF885-domain-containing-protein	gnl\|CDD\|377577	pfam05960, DUF885, Bacterial protein of unknown function (DUF885). This family consists of several hypothetical bacterial proteins several of which are putative membrane proteins.	1.18572e-91
NC_008578.1\|WP_011720788.1\|2216841_2218401_+\|trehalose-6-phosphate-synthase	gnl\|CDD\|340820	cd03788, GT20_TPS, trehalose-6-phosphate synthase. Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.	4.93958e-132

>NC_008578.1|WP_011720783.1|2207054_2208095_-|pirin-family-protein
MPAVTVDNILALPRLRHVDPAVERDRPVVSITTAPSGLEGEGFPVRRAFAGVSLAALDPFVHMDQMGEVEYAPGEPKGTPWHPHRGFETVTYMIDGIFEHHDSNGGGGLITNGDTQWMTAGRGILHIERPPEYLVASGGLFHGFQLWVNLPRRLKFAPPRYQDIRASAVSLVASPDGGALLRIIAGEVDGFRGPGITHTPIALLHVTLAAGASVTIPWPRHFNALVYALGGFGAVGAGRHPLRYGQLAVFGAGDAITVSASKQQESRSPNFDVLVLGGEPIREPVAMYGPFVMNTKAEVLQAFEDYQKGILGTIPAEHAVVPHGSVRGQASADEMTAGGTDQPAAG
>NC_008578.1|WP_011720782.1|2204964_2206482_-|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MSETSRPAAAIVLAAGEGTRMRSTRPKALFPILGRSLLGHVLAAVRALDPEELVVVTGHRRAEVEAHLAEIDPAAKPVYQTEQRGTGHAVRAALEALDAERRAAGRPTLTGTVLVTAADTPLLTPRSLAAMVAHREQTGVAGVLLTATMPDPTGYGRVLRDDSGRVRGIVEERDADPAHREIREVNAGVYAFDAAKVRAALARLTTDNAQGEEYLTDVVRIFGTEGEPIAAAVLDDWREILGVNDRAQLAVAAALLRDRKNTALMRAGVTIMDPATTWIDVDVDVAPDAEIWPNTILAGTTRVAASARIGPNCHLIDTEVGERARVRDATCENAQIGPDAEVGPYTYLRPGTRLGRGAKAGGFVEMKNAVVGAESKVPHLSYVGDATIGERTNVGAATVFVNYDGVAKHHSVVGNDVRIGSDTMIVAPVTIGDGAYTAAGSVIVEDVPPGALAIARSRQQNIEGWVVRKRPGTRAAEAAKQASAAGGPPAAGGTSGRDAGDDASR
>NC_008578.1|WP_011720781.1|2203928_2204906_-|ribose-phosphate-diphosphokinase
MTGIRRQGQKTLMLFSGRAHPELAAEVAACLGIEPTPTSAYEFANGEIFVRFDESVRGSDAFVIQSHCAPINKWIMEQLIMVDALKRASAKRITVVVPFYGYARQDKKHRGREPISARLMADLFKAAGADRLMAVDLHTAQIQGFFDGPVDHLFALPILADYIESKLDTSRITVVAPDAGRVRVAERWTDRLNCPLAIIHKRRDPLVANEVKIHEVVGAVEGRICVIVDDMIDTAGTITKAADALMENGAADVVATATHAVLSGPAVDRLKNSPISEVVVTNTLPVPSERRIDKLTVLTIAPMLARAIQEVFEDGSVTSLFNGAS
>NC_008578.1|WP_011720780.1|2203068_2203680_-|50S-ribosomal-protein-L25/general-stress-protein-Ctc
MSEVRIKAEPRTEFGKGAARRVRRAGKVPAVLYGHGTPPRHISLPGHELMLALKTPNVLLRLEGLEGPDDGELALPKAVQRNVVTGFLEHVDLLLVRRGEQVEVDVPLRFVGTHAPGGVLEEHLVALPVRADATRIPEEIEVSLDGLEIGGSIYVRDVRLPDGVTAAAEPDEVVVHLLPALTASELAEAVEGATETGAGAAAG
>NC_008578.1|WP_011720779.1|2202462_2203053_-|aminoacyl-tRNA-hydrolase
MPDEPWLVVGLGNPGPAYAKNRHNVGFMVVDLLAERAGMRFTVHRTRTQLANGRLAGQPAMLAKPLSYMNQSGGPVAGLLHYFRIPRERLIVVHDELDLPFGVLRVKRGGGDAGHNGLRSITAALRGADYLRVRFGIGRPPPHLDPAEYVLRDFSAAERAELGVHLEEAADVVESLLSVGLAATQNAVHGRGRQRP
>NC_008578.1|WP_148204610.1|2201586_2202429_+|4'-phosphopantetheinyl-transferase-superfamily-protein
MNRETVMSRARDDPEPILLTIFSALGREAEIPRLLTMFSESERARFSQHHGRENAVVTRATLRQVLSSLLRTEPGGIVIENDAHGRPRAVARRRVEFSVTHTAHVGAIIATTGRLALGIDLEWRGRVKPWTDDAVARMARRCLTTDERTEFDTLRDDEKRNAFLRAWTRKEAFLKALGTGLTTPMRHVHLGLGDIPDLRQLPAPAQGWAWRLLDLDVRHTPAACEPAGDTAVPRDFLGAIAVGLPRGRTGGLAEPEADITVRLTIDAPGFEVSVTDSGSR
>NC_008578.1|WP_011720777.1|2200677_2201541_-|glycosyltransferase
MAEPAATIVMAAHNEAAVIERTLRAFLPQSAPGEFQVLVVCNGCSDGTAEAARSTGEQTGRPVEVREIPVASKIAALRKAEDEPLVERADVRIYLDADVLVDVTTLRNVRDAVAGDMPRLGVVCGEVDAAGSSRLVRAYYAVWSARQHAAPDGSGAGIFAVNRAGAARISQWPDVLSDDGFVARQFAASERVVAAGRSVIRAPRTVSALVRRRARIVNGNRELDIRWPRTAAEPPAVRRLVLARRVSLVQAGVFVTLTIAARALAAWRRWRGRAAMWSADDTSRRAY
>NC_008578.1|WP_011720776.1|2199420_2200659_-|L-2-hydroxyglutarate-oxidase
MSTAQASADVAVIGGGIVGLAAARAVLQREPTLSLVVLEKEERLACHQSGRNSGVVHAGVYYAPGSLKARFCTAGRAALAAYTAERHLPYVECGKVVVALRDAEIPRLEELYRRSCANGVPDVRLIDADELRRIEPTARGVAALHSPRTAITDFPAIARSFADDIRAAGGRIMTAFPVQHIEQRQDTVVLTGRNGDRVVAGRVLICAGLYGDRLAVMAGDAPEPRIVPFRGDYYRLTPEWRTRVRGLIYPVPDPGLPFLGVHITPTVGGELLVGPNAVLAMAREGYRARTVRPDEVLDAIGWPGFLRFARRYWRVGCAEMWRAVSRRRFAADVAAYLPGITARDLIRARAGVRAQAMDAAGRLVDDFIVRRVGKVVAVRNAPSPAATSSIPIGEELARLLLSTDDVPAVESQ
>NC_008578.1|WP_011720775.1|2198848_2199424_-|N-acetyltransferase
MSDSSVTESPETSFFCHPTAEVEPGAQIGRDTRLWRQVHVRTGASIGVGCNIGKNVFVDEGVRIGDRVKIQNNVSVYRGVTLEDDVFVGPSAVFTNDLRPRAGSTEWTVVPTIVRRGASIGGGAVIVCGHEIGEWAMVAAGAVVTRDVAPHQLVAGNPARHRGWVCRCGQKISDAVEPPAVLTCPTCQQLQ
>NC_008578.1|WP_011720774.1|2196922_2198413_-|sugar-transferase
MVVLDEVSTLPRRTDRVLRTTRSRRAVRDRLSFLRRYGRVLAVAEGVIAALAVLVYSSGYAGRVDRAAWLQVVALGLGWPATLALLRAYEPRFLGLGSEEYRRVVHAGLGLTACIATAGYATSSLGGRGVALFAVPGAMTATLVTRYGARKWLHFQRRQGRHLQRVLIVGHDATAAELAEAMRREAYAGLFVVGACVPGGKAGSHHRLDAAGVPVIDDLESVTRAVVAVDAAAVAVLPCPELCGPKLRKLGWDLEAAGVDLIVAPTIVDVTGPRIHIRPLAGLPLLHVEAPEFHGFRRVLKEAFDRFAAAIALIVLSPLLLAVAIAVVATSDGGAFFCQQRVGKGGKSFRMYKFRSMYADAEHRLTELLDKNKHGATGVLFKLVDDPRVTPVGRFLRRYSLDELPQLVNVLLGHMSLVGPRPPLAREVAMYGPEAKRRLLVKPGLTGLWQISGRSDLDWQTSVRLDLWYVENWSFWLDLMILWKTAFAVVRGSGAY
>NC_008578.1|WP_011720784.1|2210163_2210490_-|CRISPR-associated-endonuclease-Cas2
MLKDEPVWAIAAFDLPTQTREQRRDANRYRHHLLELGFSRVQLSVYAKYMINGAGFRWVGSAAGAVVPPGGVLRVIPVSDHEWARALCYVGERLVPPEDPPQQLAIFP
>NC_008578.1|WP_011720785.1|2210482_2211370_-|type-II-CRISPR-associated-endonuclease-Cas1
MTGPWRVVDLSELSGEVHAAQGALLVGDERVPLVDVAMMLTGPYVSLHGSVIDRAAAFGVGVVHCDWRGVPVAATLPWSTHNRVAARHRAQAELSLPRQKNAWMNIVKTKIRNQAAVLRALRRDGVAQLERLAAQVRSGDASNAEGAAARVYWARLFQDKHFRRVPRARDVVNGLLDYGYAILRGCCLRAVVGAGLAPSLGLWHRRHDNPFTLVDDLIEPFRPAVDKTVIEIVTAGASGLDRPTKRLLVAVLDHQFDASGATVGTAVERFAQQVGRYVEGEIRSLRPPAMELSHA
>NC_008578.1|WP_041835088.1|2211366_2214840_-|HNH-endonuclease
MSLQLIIKGVEYGRGADPTMGGSEVGTVPVTWRLGVDVGERSIGLAAVSYEEDKPKEILAAVSWIHDGGVGDERSGASRLALRGMARRARRLRRFRRARLRDLDMLLSELGWTPLPDKNVSPVDAWLARKRLAEEYVVDETERRRLLGYAVSHMARHRGWRNPWTTIKDLKNLPQPSDSWERTRESLEARYSVSLEPGTVGQWAGYLLQRAPGIRLNPTQQSAGRRAELSNATAFETRLRQEDVLWELRCIADVQGLPEDVVSNVIDAVFCQKRPSVPAERIGRDPLDPSQLRASRACLEFQEYRIVAAVANLRIRDGSGSRPLSLEERNAVIEALLAQTERSLTWSDIALEILKLPNESDLTSVPEEDGPSSLAYSQFAPFDETSARIAEFIAKNRRKIPTFAQWWQEQDRTSRSDLVAALADNSIAGEEEQELLVHLPDAELEALEGLALPSGRVAYSRLTLSGLTRVMRDDGVDVHNARKTCFGVDDNWRPPLPALHEATGHPVVDRNLAILRKFLSSATMRWGPPQSIVVELARGASESRERQAEEEAARRAHRKANDRIRAELRASGLSDPSPADLVRARLLELYDCHCMYCGAPISWENSELDHIVPRTDGGSNRHENLAITCGACNKEKGRRPFASWAETSNRVQLRDVIDRVQKLKYSGNMYWTRDEFSRYKKSVVARLKRRTSDPEVIQSIESTGYAAVALRDRLLSYGEKNGVAQVAVFRGGVTAEARRWLDISIERLFSRVAIFAQSTSTKRLDRRHHAVDAVVLTTLTPGVAKTLADARSRRVSAEFWRRPSDVNRHSTEEPQSPAYRQWKESCSGLGDLLISTAARDSIAVAAPLRLRPTGALHEETLRAFSEHTVGAAWKGAELRRIVEPEVYAAFLALTDPGGRFLKVSPSEDVLPADENRHIVLSDRVLGPRDRVKLFPDDRGSIRVRGGAAYIASFHHARVFRWGSSHSPSFALLRVSLADLAVAGLLRDGVDVFTAELPPWTPAWRYASIALVKAVESGDAKQVGWLVPGDELDFGPEGVTTAAGDLSMFLKYFPERHWVVTGFEDDKRINLKPAFLSAEQAEVLRTERSDRPDTLTEAGEILAQFFPRCWRATVAKVLCHPGLTVIRRTALGQPRWRRGHLPYSWRPWSADPWSGGTP
>NC_008578.1|WP_011720787.1|2215153_2216782_-|DUF885-domain-containing-protein
MTVASTPEPAADFERFASEAVDQLLAYQPSLATAIGDHRFDDRLEDLRPAAVNDEIRALRAVLTRLERYPLDRLPVGHRVDAEILRNKVAERLFELETLREHEWNPLQANPGTALYLLLARDFAPLDDRLRALAGRLAAVPEQLAAARASSRDMPRVHVETAIDQFSGTLRLLEDEIPAHAQGSPYAGLVAERLAPAVEAVRTHLAWLCEQLDQADGDPRLGPELYTAKLALVLDVARRPEDVAAAAWAEVQRVEQAMVETAGRLGGSPQEIFARLAEQAPNDETVITEARSALAEATEFVQGRELVTYYADPLDIIVMPEIHRGVAVAYCEPPGPLDPPDTPTFFAISPAPASWPSERVASFYREYNVHALRNLVVHEAMPGHMLQLAHARRSETPTLVRRAFWSGPFVEGWAVYAEEVMARYGFGGLAVAMQQLKMRLRTALNAVLDVGVHCEGLTEEEALRLLRDRGYQEEGEAVGKWRRALLTSAQLSTYHVGVLEVSEVAAQLRAAHPEWSDRRLHDTLLSFGNPPPRHLPRLLGLA
>NC_008578.1|WP_011720788.1|2216841_2218401_+|trehalose-6-phosphate-synthase
MAERAGGRWQLGVPVIVASHRAPVQFRREGGRRIARRGAGGLVTALLGLVREIPDAVWVCAASTEEDAAVVAEHRGKAIPIAVGPLPRIADPDAHDEPVAAIRMVEIDPAAREDFYSVISNPMLWFVQHGLYDLTRAPNIDEVEHEAFEHGYVAVNRAFADTIAEEVESRGGRALVMLHDYHFYLVAAMVRERCPDVVLSHFVHIPWPGPDAWRVLPPHMRDQIFAGLLGNDIVAFHTERFARNFLLCAQELLGLPINLDKMTVQYGPRTIAAKTYPISIDVDALEEVARSKAVRTRLDDLETWLAAEGGKLIVRVDRTDPSKNIVRGFLAFERLLDDHPELVGKVRFLAFLQPSRLDVPEYVEYIGRIGSVVARINAKYTRGGEAPIDLRLHEDFLTAVAAYSICDVVMVNSIADGMNLVAKEAVCVSRRNAVLALSENTGAYEELGAFAVTLYPFDIQQQADALYIALMMPEEERRERLEAAAEIVRANNVTKWLDFQLTDLAEFTGLWSWKPTRSS
>NC_008578.1|WP_148204704.1|2218370_2220059_+|FAD-dependent-oxidoreductase
MVVETDAIVIGSGPNGLVAANLLADAGWSVLVVEAAQQPGGGVRSGRYVDPDFISDACSAFYPLAIASPAMQAMQLERYGVRWRHADFAFAHPLPDGRALAVSRDVTETAALLDDVAPGSGAGWMELAALWKRAAPALMDALCTPFPPVRAGVRLARALYRSGLGRFARMALLPVRRFAEEWVREPTGLLFAGNALHADFAPESTMSGLYGWLLAMLAGDVGFPVPQGGAQRVTDALLARLRDRDGELLCGRRVTGILIRSGRAVGVRLADGDEIAARRAVLAAVPAPSLYGELIPPEHVPENVRRDLRNFQWDFGTVKIDWALHEPIPWTNDLVRRAGTVHIGASMDDLTRYAADLAMGLVPARPFVVLGQLSTVDPSRSPAGTESLWGYTHIPQQIRGDAGPDGISGAWTETEIEAFVRRIEDHIERYAPGFRECIKTRVVRGPAAMDADHPGLHNGAFGQGTAALHQQLIFRPLPGVARPETPIPGLYLASSSAHPGPGVHGACGANAARAALRADHLATRIFGAPLRRVCERVIRGPEHPASQRPVLDSPDRPPKRLS
>NC_008578.1|WP_011720790.1|2220055_2220979_+|DMT-family-transporter
MTYLLGVAAAIFLGLGFTLQQHAAASAPASDFLRIRLLIDLLHKPIWIVGVLSMIAGQVLSAMALATADVSLVEPLLSANVLFALILARLLYHQPLGLREWSGSLVLSAGVGVFLWAGDPRGGDPDTDSLLRWVLAIGVLLLAQLCVVEARRRGGEVRPMLLAAAAGLLFGVQDGLTRRATAAWHAGIAKIFLHWAPYTLIAIGIVAMLLAQSAFETGRLRTTLPVIAAAEPLAGIAMGVIVFGERVRLDTLPLAGEACGLAAIVAGVVLVGTSQNFRQLEQALLRRRPRLSHRHADLRLTRNHTVD
>NC_008578.1|WP_011720791.1|2221021_2222395_-|NADP-dependent-succinic-semialdehyde-dehydrogenase
MAIATVNPATGEVVKTFDPMTPAEIDAKLTAALQGFQTLAAWSFERRAAAMREAARILDEEREEIARILTIEMGKTIRSARAEVSKCARALRFYAEHAEEFLADEPADAAAIGASRAFVRYQPIGPVLAVMPWNYPLWQVIRFAAPALMAGNSGVLKHASNVPQAALFLEELFRRAGFPDGAFVTVLVGSDAVEKIIADPRIRAVTLTGSEYAGRQVAAIAGRELKKTVLELGGSDPFIVLPSADIERAAEVATTTRCQNNGQSCIAAKRFIVHAEVYEAFAEAFVAKMSALKVGDPLDDATEIGPLATEQGRADVEELVEDARAKGAQILCGGRRPEGPGWWYPPTVVAGVTPQMRMFDEEVFGPVAGLYRVTSADEALRLANATPFGLGSNVWTRDLAEAEHFVNGLEAGMVFVNGMTTSYPEVPFGGIKNSGYGRELSAHGIREFCNIKTVWIG
>NC_008578.1|WP_011720792.1|2222585_2223509_-|sulfite-exporter-TauE/SafE-family-protein
MHIAPDLSIAGALVGFLIGLTGMGGGALMTPILIMFFGVAPLAAVSSDLVASLFMKPVGAAVHWRRGTVHHRLALWLIVSSVPAAFGGVLLIRALGGSHVQSTVKVLLGVVLLLTIASMLVRNRLTRHVPVVAVSQVKVRPLLTVAIGVFGGLAVGMTSVGSGTLVIALLLLAYPQLRAGQLVGTDLVQAIPLVGAAALGHALFGDVKISVTLSLLVGAIPGVYLGARLSAGRAVGWVRPILTVVLLASAVKLVGAPTPLTLSVTGIWVVLQIGAAFAPRISRRLVIRRILRQAAAETPSRTPDAVG
>NC_008578.1|WP_011720793.1|2223967_2224744_-|MarR-family-transcriptional-regulator
MRTETSSDARHPSRRGLTSPAESRRDCERSSPGPDDHDVRRGDDVVRRIAALLDASGTLRRVLRARMRSAWPYDDLPVGQLDLLRLLVESPGLSVNQAAERLALAPNSVSTMVRGMIAAGLVERRSDPADARAARLYPSAHAAARLRRWRARRAQVLAAALPRLDGDHDWLDAAVAAVERLTAILAGDDETGVPDPADATAVARRPADRHGRRSASGGGKALPGGADEPRPASGSTSGRGKTHKIGRGTRLIDRDLPE

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Crispr_ID: NC_008578_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008578_18

2284553-2284644

Orphan

Consensus_repeat	Method
CCTGACCGGCTCACGCGGGGGACCAGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008578_18

>merge|NC_008578|18|2284553-2284644|CRISPRCasFinder
CCTGACCGGCTCACGCGGGGGACCAGGTGGCACGGCTGCGAATCCGCCGGACGCGCCCAACATTCCTGATCGGCTCACGCGGGGGACCAGGT

>NC_008578|18|18|2284553-2284644|CRISPRCasFinder
CCTGACCGGCTCACGCGGGGGACCAGGT	GGCACGGCTGCGAATCCGCCGGACGCGCCCAACATT
CCTGATCGGCTCACGCGGGGGACCAGGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008578.1\|WP_011720835.1\|2274219_2274378_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379366
NC_008578.1\|WP_011720839.1\|2277484_2279947_+\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223815
NC_008578.1\|WP_083760592.1\|2292771_2293134_+\|cold-shock-domain-containing-protein	unknown	unknown	gnl\|CDD\|278729
NC_008578.1\|WP_049751518.1\|2294003_2294513_-\|tRNA-adenosine-deaminase-associated-protein	unknown	unknown	gnl\|CDD\|274869
NC_008578.1\|WP_011720849.1\|2289199_2289736_-\|DUF5063-domain-containing-protein	unknown	unknown	gnl\|CDD\|374737
NC_008578.1\|WP_011720850.1\|2289728_2290328_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NC_008578.1\|WP_011720851.1\|2290439_2292353_-\|DNA-polymerase-III-subunit-gamma-and-tau	unknown	unknown	gnl\|CDD\|236090
NC_008578.1\|WP_011720841.1\|2280645_2281545_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|224326
NC_008578.1\|WP_011720853.1\|2293530_2293965_-\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NC_008578.1\|WP_011720848.1\|2288381_2289167_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720846.1\|2285964_2287026_-\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NC_008578.1\|WP_011720836.1\|2274486_2275527_+\|ATPase	unknown	unknown	gnl\|CDD\|223082
NC_008578.1\|WP_011720840.1\|2279952_2280507_-\|GatB/YqeY-domain-containing-protein	unknown	unknown	gnl\|CDD\|370480
NC_008578.1\|WP_169303214.1\|2282355_2282574_+\|hypothetical-protein	unknown	unknown	unknown
NC_008578.1\|WP_011720847.1\|2287052_2288321_-\|aspartate-kinase	unknown	unknown	gnl\|CDD\|235843
NC_008578.1\|WP_083760590.1\|2275523_2276879_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223082
NC_008578.1\|WP_049751658.1\|2276911_2277220_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NC_008578.1\|WP_011720834.1\|2273729_2274215_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100006
NC_008578.1\|WP_011720855.1\|2294648_2296025_-\|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta	unknown	unknown	gnl\|CDD\|376743
NC_008578.1\|WP_011720842.1\|2281738_2282227_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|153102

Protein	Function_ID	Function_description	E-value
NC_008578.1\|WP_011720835.1\|2274219_2274378_-\|hypothetical-protein	gnl\|CDD\|379366	pfam13783, DUF4177, Domain of unknown function (DUF4177).	0.000117096
NC_008578.1\|WP_011720839.1\|2277484_2279947_+\|penicillin-binding-protein	gnl\|CDD\|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	5.75193e-157
NC_008578.1\|WP_083760592.1\|2292771_2293134_+\|cold-shock-domain-containing-protein	gnl\|CDD\|278729	pfam00313, CSD, 'Cold-shock' DNA-binding domain.	2.52952e-34
NC_008578.1\|WP_049751518.1\|2294003_2294513_-\|tRNA-adenosine-deaminase-associated-protein	gnl\|CDD\|274869	TIGR03941, conserved_hypothetical_protein, putative tRNA adenosine deaminase-associated protein. This model describes a protein family about 200 amino acids in length with only five invariant residues, including an Arg, a Ser-Asp pair, and two Gly residues. Members always are found exclusively in Actinobacteria, and always adjacent to homologs of TadA, a tRNA-specific adenosine deaminase from Escherichia coli. Homology, phyletic pattern, and gene neighborhood together suggest a housekeeping function in tRNA metabolism. [Unknown function, General].	7.36403e-41
NC_008578.1\|WP_011720849.1\|2289199_2289736_-\|DUF5063-domain-containing-protein	gnl\|CDD\|374737	pfam16702, DUF5063, Domain of unknown function (DUF5063).	1.44331e-48
NC_008578.1\|WP_011720850.1\|2289728_2290328_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	1.76974e-124
NC_008578.1\|WP_011720851.1\|2290439_2292353_-\|DNA-polymerase-III-subunit-gamma-and-tau	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0
NC_008578.1\|WP_011720841.1\|2280645_2281545_+\|metallophosphoesterase	gnl\|CDD\|224326	COG1408, COG1408, Predicted phosphohydrolases [General function prediction only].	1.71915e-55
NC_008578.1\|WP_011720853.1\|2293530_2293965_-\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	1.25878e-64
NC_008578.1\|WP_011720846.1\|2285964_2287026_-\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NC_008578.1\|WP_011720836.1\|2274486_2275527_+\|ATPase	gnl\|CDD\|223082	COG0003, ArsA, Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning].	3.5724e-28
NC_008578.1\|WP_011720840.1\|2279952_2280507_-\|GatB/YqeY-domain-containing-protein	gnl\|CDD\|370480	pfam09424, YqeY, Yqey-like protein. The function of this domain found in the YqeY protein is uncertain.	4.86289e-48
NC_008578.1\|WP_011720847.1\|2287052_2288321_-\|aspartate-kinase	gnl\|CDD\|235843	PRK06635, PRK06635, aspartate kinase; Reviewed.	0
NC_008578.1\|WP_083760590.1\|2275523_2276879_+\|AAA-family-ATPase	gnl\|CDD\|223082	COG0003, ArsA, Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning].	4.39068e-48
NC_008578.1\|WP_049751658.1\|2276911_2277220_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	5.16129e-26
NC_008578.1\|WP_011720834.1\|2273729_2274215_-\|RidA-family-protein	gnl\|CDD\|100006	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	1.89355e-67
NC_008578.1\|WP_011720855.1\|2294648_2296025_-\|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta	gnl\|CDD\|376743	pfam02233, PNTB, NAD(P) transhydrogenase beta subunit. This family corresponds to the beta subunit of NADP transhydrogenase in prokaryotes, and either the protein N- or C terminal in eukaryotes. The domain is often found in conjunction with pfam01262. Pyridine nucleotide transhydrogenase catalyzes the reduction of NAD+ to NADPH. A complete loss of activity occurs upon mutation of Gly314 in E. coli.	0
NC_008578.1\|WP_011720842.1\|2281738_2282227_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|153102	cd01043, DPS, DPS protein, ferritin-like diiron-binding domain. DPS (DNA Protecting protein under Starved conditions) domain is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. Some DPS proteins nonspecifically bind DNA, protecting it from cleavage caused by reactive oxygen species such as the hydroxyl radicals produced during oxidation of Fe(II) by hydrogen peroxide. These proteins assemble into dodecameric structures, some form DPS-DNA co-crystalline complexes, and possess iron and H2O2 detoxification capabilities. Expression of DPS is induced by oxidative or nutritional stress, including metal ion starvation. Members of the DPS family are homopolymers formed by 12 four-helix bundle subunits that assemble with 23 symmetry into a hollow shell. The DPS ferroxidase site is unusual in that it is not located in a four-helix bundle as in ferritin, but is shared by 2-fold symmetry-related subunits providing the iron ligands. Many DPS sequences (e.g., E. coli) display an N-terminal extension of variable length that contains two or three positively charged lysine residues that extends into the solvent and is thought to play an important role in the stabilization of the complex with DNA. DPS Listeria Flp, Bacillus anthracis Dlp-1 and Dlp-2, and Helicobacter pylori HP-NAP which lack the N-terminal extension, do not bind DNA. DPS proteins from Helicobacter pylori, Treponema pallidum, and Borrelia burgdorferi are highly immunogenic.	2.26084e-48

>NC_008578.1|WP_169303214.1|2282355_2282574_+|hypothetical-protein
MAVQQPELTESVWSAVGAVKHGYPPPVRAPGTLTTAYCGELIVVQGECTDRPPRDACPLCALAWEQRRRRPW
>NC_008578.1|WP_011720842.1|2281738_2282227_-|DNA-starvation/stationary-phase-protection-protein
MPAHARVSEPAARFVGSQRLAEHLQAVLADLIELHMQGKQAHWNVVGPNFRDLHLQLDEIVNLAREAGDTVAERMRALHATPDGRTATVAGSTSLPAFPPGEQSTKRVVDLMTERLVRAAATVRRVLPDVEAEDPPTANMLQEIITDLEKHAWMLSAENVGV
>NC_008578.1|WP_011720841.1|2280645_2281545_+|metallophosphoesterase
MVTRSVWLVPLGLATAAVGYAAGIERRTPVLRRVTVPVLPEGERPLRVLHISDAHLTPRQGWKRRWLRKLDDLQPDVIVNTGDSIAHPEAVPAFVDAIQPLLARPGVFVLGSNDRYAPRFKNPLRYLLPDDGRRVHGPMLPWRELVDSLERHGWRHLGNARAVLEIGGRRVEFRGVDDPHIWCDRYDDIAGPVDRNVLIGIGVTHSPEPRVVSRMAADGCRLVLAGHTHGGQLRVPFYGALVTNCGLDRRRARGLSRYDATWLHVSAGLGTSPLAPVRFSCPPEATLITLVGRDHAPVG
>NC_008578.1|WP_011720840.1|2279952_2280507_-|GatB/YqeY-domain-containing-protein
MQIPLEERPGAPGSDEERPGAPGSDARLNSMSLKERLRADLAHAIKARDEVRTATLRMALAAITTEEVSGATARTLTDEDIIKVLLRERKKRDEAAEAFAAAGRQDLADRERAEAEVIAAYLPEPLSDDELRAAVREAIAEVGAVPGPEGARFIGPVMKLLTARLSGRADGSRIAAEVRQQLAG
>NC_008578.1|WP_011720839.1|2277484_2279947_+|penicillin-binding-protein
MATGTSTEGRLGPGRIFGHLLTLGFLALLTGALVAALALPVVGGAGLAVRDMIGNISFTDLPPELQTPPLAQRSVILAADGTELATFYYENRQSVSLSDVAPDMREAIVAIEDARFYEHHGIDPIGILRALIRDTSSGSAVQGASTITQQYVRQALVEINTQNENQAGAKAATAKTLSRKLTEARYALALEQKLSKDQILEDYLNTVYFGSGAYGIAAAAQHYFSEDPSQLTLPQAALLAGVVNNPSRFDPILNPQDALARRNVVLQRMADLHYITQAQADAAMQAPIGLKVSKIPNGCATSVAPFFCQYVVDEILNNPAFGPTRAARTNLLLRGGLTISTTLDMHMQAAAQNAVNTVIPPDPTKNAGLAAAIDIVDPKTGAIRAMAVDRAFGSGEGETEVNLAADLAHGGSSGRHAGSTFKIFVLASALQQGIPTGLTLVSPNRITIKKGAMTDCNGAPTSEWNVANAGDSEAGTFDMVQATKLSVNTYFAQLEEKTGLCKPIQIAEAMGVRQATGAPLDQVPSFVLGAEDVDPLTIAGAFATLANQGTYCPPFAITAVTRQLGDTTTSIQVPASTCRRAIDPAIANGVTSLLTHVLEPGGTGAGLGIGRPAAGKTGTDDEYRNAWFSGYTPNLAASVWVGNPDSTTPMRAITVNGHYYREVFGATLAGPIWQKAMQEAVKNLPVQAFPQAPDSVLKGQPITVPDVAGQDPQTAVTTLQQLGLVVTVDPTPVYSDQPANTVAGTDPPAGSTVYVGNTITVHLSNGAGPSPSASLSPSASPSATESPSASPSPSASSSPPLIVPLPPPHHPGRGAPTPSG
>NC_008578.1|WP_049751658.1|2276911_2277220_-|WhiB-family-transcriptional-regulator
MAWIKDWAAYAACRNVDPDALFVQGAAQNRAKAICYRCPVRAECLADALDNRVEFGVWGGLTERERRALLRRRPNVTSWRRLLAAAMEDFERSHRDGVSAAS
>NC_008578.1|WP_083760590.1|2275523_2276879_+|AAA-family-ATPase
MTANDSVLPPAEESTPLASESTRRAPRRSSPTLPSSLHADAPADQPAPIRTRRSPASARPTRSTPRHRQPTNGTPSGVRAPRLDVDALLMNPGTQIIVCCGSGGVGKTTLAAALGLRAAEAGRRVVTLTIDPARRLAQSLGMTELDNTPRPVPGVRGTGELHAMMLDMKRTFDEIVEAHTTPARAAQILANPFYQSLSSSFAGTQEYMAMEKLGQLKASGRFDLIVVDTPPARSALDFLDAPARLARFLDGRFIRTLLVPTGRGYLRVVHAGLQFVTATMTRLLGAALLADVQTFVAAMDTMFGGLRERAEATARLLRTPGTAFVVVAAPEPDALREASYFIERLIEDNLPLAGVVINRLHLSGAPEISAAQARAAAETLDGAADDDTVFAAAVLRTHAQRMEIAAVEHKRLHGFTVAHPRVPVAFAPAFADDIHDVAALRTLGSSIAAGT
>NC_008578.1|WP_011720836.1|2274486_2275527_+|ATPase
MGVDRDWEGVRLHVVTGKGGTGKTTVAAALALALASDGRRALLVECEGRQGIARLFDTPPLPYAERKLAVAPGEGMVYGLAIDPEQALLEYLEMYYHLGRPARVLQRVGAIDFATTIAPGLRDVLLTGKVYEATRRRFSGSRPARTAARIVRHDGVPADAYVYDAVVLDAPPTGRITRFLNVNAEVADLARVGPINRQAASIMSLLRSPQTAVHLVTVLEDMPVQETLDGIAELRRQQLPVGAIVINRVQPAHLPTSALRAVARGEVDTAALQRGLAKLGIAAEPSTVDALAAETIDAARTAVRERRLRHTLSQAGRPTYDLPELDIGDIARLYTLAAALREQGAA
>NC_008578.1|WP_011720835.1|2274219_2274378_-|hypothetical-protein
MSAWEYATVPLLVHATKQILDTWGADGWELVTVIPGPGPDQLVAYFKRPRQA
>NC_008578.1|WP_011720834.1|2273729_2274215_-|RidA-family-protein
MTASTPEERLAALGLRLPAVARPVAAYVPAVRTGRYVYTSGQLPMVDGELVETGKVGTDVDAEVSPEAARAAARICALNALAAIRDLIGDLAKVRRVVKVVGYVASSRSFTGQPGVINGASELLTEVFGDAGAHARSAVGVAVLPLDAPVEVEVIVEVADD
>NC_008578.1|WP_011720846.1|2285964_2287026_-|aspartate-semialdehyde-dehydrogenase
MTERSFHVGIVGATGQVGGVMRRILAERHFPVASIRFFASARSAGRTLPWQDGEVVVEDAAAADPAGLDIVLFSAGAGTSRALAPKFATAGAVVIDNSSAWRMDPDVPLIVAEVNPHALSGMRKGIIANPNCTTMAAMPVLKPLHDAAGLIRLVASTYQAVSGSGLAGVEELDKQVRQVVDRAHDLTHDGRAVDFPAPQKYVRPIAFNVVPVAGNFVDDGSGETDEEQKLRNESRKILGIPDLRVSGTCVRVPVFTGHSLSINAEFARPLPASRAVELLESAPGVRVVDVPNPLEAAGTDPSYVGRIRQDHSVPDNRGLVLFVSNDNLRKGAALNAVQLAELVAAQWSSLPRR
>NC_008578.1|WP_011720847.1|2287052_2288321_-|aspartate-kinase
MPLIVQKYGGSSVADAERIKKVAQRIVATRKQGYDVCVVVSAMGDTTDELLDLAAQVSPMPPPRELDMLLTAGERISMALLAMAIANLGMEARSFTGSQAGVITDSRHGRAQIIDVTPGRIREALAAGHIAIVAGFQGVAQDTKDVTTLGRGGSDTTAVALAVALGAEVCEIYTDVDGVFTADPRIVPTARQIPRISYEEMLEMAAAGAKILHLRCVEYARRFKMPIHVRSSFSTKPGTWIVDIPPEEQMEAPIISGVAHERGEAKITVVGVPDKPGEAAQIFQVIADAGINVDMIVQNVSSTATGRTDITFTLPTSDLPTAMAALSKAKDRIGFEGLLSDDQIGKVSLIGAGMRTQPGVTAKFLTALADAGINVEMISTSQIRISVVIREDDLPAAVAALHRAFELDDPEGQAVVYGGTGR
>NC_008578.1|WP_011720848.1|2288381_2289167_+|hypothetical-protein
MPRSAGGRSSRGVRWPAPVVVCSAVGLVGVLLAGCSAHQPTPPPSTGAQTSTAGPLLALRAAAARALHASYTATYRALGTSPPRSGTVAVYRTPDAVRLDVTETGAAALRILVTAQGTFSCTLPGPPTPPPTGTSAPACVTLAGPKSTVPPSLDPGLQHVFTSTLEALAGSDDVRVAGTPEPRTIAGYSATCFAVTFTAASIALTPGTYCFTADGILAAALFRSSSISLISVDGAPVPGDFQLPASPVPLTPQPTPAGSGG
>NC_008578.1|WP_011720849.1|2289199_2289736_-|DUF5063-domain-containing-protein
MSDPLVESRSEDLGEFAAEIADQVESFVIAVREIARSTDAGSAVSLLLLEVSQLLLAGGRLGAITDIVPPEPFEPDVGPDPDIDDLRTRLAKLLAPIDRYVEIFDPYENPPSATTFVISDDLALIVSDLLHGLAHFRAGRPVEALWWWQFSYLSHWGTHAGAMVRALQSVVAHDRLDV
>NC_008578.1|WP_011720850.1|2289728_2290328_-|recombination-protein-RecR
MYEGVIQDLIDELGKLPGIGPKSAQRIAFHILGADPSQVRRLAEVLLDVKERIRFCAICGNVAEHEQCRICADPRRDPTVLCVVEEPKDVVAIEKTREFHGRYHVLGGAISPIDGIGPDDLRIRELLQRLADGTVKELILATDPNLEGEATATYLARLVKPLGVRVTRLASGLPVGGDLEYADEVTLGRALEGRRQLDV
>NC_008578.1|WP_011720851.1|2290439_2292353_-|DNA-polymerase-III-subunit-gamma-and-tau
MTLALYRKYRPATFAEVIGQEHVTEPLRQALRHNRVHHAYLFSGPRGCGKTSSARILARSLNCEQGPTPDPCGVCQSCRDLAPSGPGNVDVIEIDAASHGGVDDARDLRERSFYAPAVSRFKVYIIDEAHMVTAAGFNALLKLVEEPPPHLKFVFATTEPDKVLPTIKSRTHHYPFRLVPPAVLRQHLAHICEQEKVAIEPGALNLVVRAGAGSVRDALSILDQLIAGAGSEGVTHRYAAALLGYTDAALLDEAIEGLARGDGPAVFSVVTSVIDAGHDPRRFAEDILQRLRDLIVVDAVPDAPARGLLDVPEDAMDRMRRQAAAFGRTALLRAAEIVSAGLAEMRGSVAPRLVLELIVARLLVPAADRGETGVLARLERIERRLGLSAGGSVAGELPDQGQATGPSTRPSRAVDEPVRHGPAVGEPGRESAQPRTGSRPSAREAVESSAGPPGREAVDSSASPRVPRRDAPADQAAVLRAWDDVLEATKQRRRVAHSLLISGPAQVVDVRGSTIVVGFTTPALERQFALGPRNEEALAGALTDVLGGQWRIETTVLGSTGSGPEVTGTAAVGAERPHSSTSGNRGAAEPRDPEPDDLPGDGVDPDDPPVETSESETEHLALLQRHLGATVIEEDVD
>NC_008578.1|WP_083760592.1|2292771_2293134_+|cold-shock-domain-containing-protein
MASAWRYGGGPASVIEGRSSQHVFSHAAEPLRGDTHRGGRSAARCGRRSSSKESTLQGVVKWFNAEKGFGFIAVDGGSDVFVHYSAIQGEGYRTLAENQRVDFEITQGQKGPQAANVRPI
>NC_008578.1|WP_011720853.1|2293530_2293965_-|nucleoside-deaminase
MRLALQEAARAEKVADVPVGAIVLGPGGDVLGRGHNQREAAADPTAHAEIVALRAAAWRLGRWRLDGCTLVVTLEPCTMCAGAIVLARLDRLVYGAVDPKSGAVGSLWDVVRDRRLNHRPEVIAGVLADECGQVLRTFFSGRRG
>NC_008578.1|WP_049751518.1|2294003_2294513_-|tRNA-adenosine-deaminase-associated-protein
MERETTVSQLAALVAKDGHRWHGAEIDLGELRDIDDLADAMRLAARGDEPVFVFVEEDDEWFAVVRIDGGEEPRVFVSDVRMLAVSDIAERFFADLVVDTAETETDDAVAGARMRADAQPGGDTGILADFGISAKQLVAMCRREGQVPADVITEIADQLGCVDEIEVYR
>NC_008578.1|WP_011720855.1|2294648_2296025_-|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta
MSNGVLFAYFVTALCFILALKGLSSPKYARYGNLIGAFGAALAVVVTLTLHGLGHRLPIIIAIVVGTLIAVPAARLVKMTEIPQMVAMFNGVGGAAAALVSLNEYVKQHAVDSGGVAAAVVFSGIVGSVSFTGSLVTFAKLQGIMTGRPIVLPAARVVTPVVALASLGLGIAGIALTSVPLVVVCAVLALLLGVLFVLPVGGADVPVVISLLNAFTGLTVAASGYVLQNTLLIVAGTLVGASGTLLTQLMAQAMGRPLTGILFGAFAGPTTAGSTAELAGDRAVRSAGAEDIAILLGYARKVAIVPGYGLAVAQAQHTARELADVLEARGVQVFYAIHPVAGRMPGHMNVLLAEANVPYEQLKEMDAANSEFSSTDVAVVVGANDVVNPAARDLPGSPLYGMPILNVDEAANVVFLKRSLRPGFAGIDNALLYHPKTTVFFGDAKESLAKIVAAVKNL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_008578_13	13.1\|2003911\|19\|NC_008578\|CRISPRCasFinder	2003911-2003929	19	NC_008578.1	1787902-1787920	2	0.895

1. spacer 13.1|2003911|19|NC_008578|CRISPRCasFinder matches to position: 1787902-1787920, mismatch: 2, identity: 0.895

cgtggcggccggtccggtg	CRISPR spacer
cgtagcggccggcccggtg	Protospacer
***.********.******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MF140413	Mycobacterium phage Kingsolomon, complete genome	42403-42430	3	0.893
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MK878900	Mycobacterium phage MsGreen, complete genome	42397-42424	3	0.893
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	KT372003	Mycobacterium phage Lumos, complete genome	42394-42421	3	0.893
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MT889391	Mycobacterium phage MiniMac, complete genome	42220-42247	3	0.893
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MK494099	Mycobacterium phage Typha, complete genome	32833-32860	3	0.893
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MH727559	Mycobacterium phage Samty, complete genome	42404-42431	3	0.893
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MF140405	Mycobacterium phage Clautastrophe, complete genome	42397-42424	3	0.893
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MT889383	Mycobacterium phage MiniLon, complete genome	42222-42249	3	0.893
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	KT281791	Mycobacterium phage Lolly9, complete genome	42221-42248	3	0.893
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MN096377	Mycobacterium phage Finnry, complete genome	42667-42694	3	0.893
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NC_028778	Mycobacterium phage Snenia, complete genome	42398-42425	3	0.893
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MF140421	Mycobacterium phage Nicholas, complete genome	42403-42430	3	0.893
NC_008578_4	4.1\|641398\|26\|NC_008578\|CRISPRCasFinder	641398-641423	26	NZ_CP021016	Xanthomonas citri pv. phaseoli var. fuscans strain CFBP6991 plasmid pF, complete sequence	108608-108633	4	0.846
NC_008578_4	4.1\|641398\|26\|NC_008578\|CRISPRCasFinder	641398-641423	26	NZ_CP020890	Xanthomonas citri pv. citri strain TX160197 plasmid unnamed1, complete sequence	101352-101377	4	0.846
NC_008578_4	4.1\|641398\|26\|NC_008578\|CRISPRCasFinder	641398-641423	26	NZ_CP020883	Xanthomonas citri pv. citri strain TX160042 plasmid unnamed1, complete sequence	25154-25179	4	0.846
NC_008578_4	4.1\|641398\|26\|NC_008578\|CRISPRCasFinder	641398-641423	26	NZ_CP020886	Xanthomonas citri pv. citri strain TX160149 plasmid unnamed1, complete sequence	112384-112409	4	0.846
NC_008578_17	17.16\|2209604\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209604-2209631	28	NZ_CP032325	Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence	603878-603905	4	0.857
NC_008578_17	17.16\|2209604\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209604-2209631	28	NC_022061	Mycobacterium phage KayaCho, complete genome	31204-31231	4	0.857
NC_008578_17	17.16\|2209604\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209604-2209631	28	KJ433975	Mycobacterium phage 40BC, complete genome	31228-31255	4	0.857
NC_008578_17	17.16\|2209604\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209604-2209631	28	KJ433973	Mycobacterium phage 39HC, complete genome	31228-31255	4	0.857
NC_008578_17	17.16\|2209604\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209604-2209631	28	NC_024145	Mycobacterium phage Hosp, complete genome	29421-29448	4	0.857
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	HQ316582	Vibrio phage henriette 12B8, complete genome	103968-103995	4	0.857
NC_008578_1	1.1\|40655\|31\|NC_008578\|CRISPRCasFinder	40655-40685	31	NZ_CP032348	Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence	221843-221873	5	0.839
NC_008578_17	17.16\|2209604\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209604-2209631	28	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	491408-491435	5	0.821
NC_008578_17	17.19\|2209796\|29\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209796-2209824	29	LN997843	Streptomyces reticuli genome assembly TUE45, plasmid : II	596189-596217	5	0.828
NC_008578_17	17.21\|2209925\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209925-2209952	28	NZ_CP022992	Paraburkholderia aromaticivorans strain BN5 plasmid pBN2, complete sequence	156037-156064	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MH595538	Vibrio phage BONAISHI, complete genome	54401-54428	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MT354569	Pseudomonas phage phiK7B1, complete genome	1102-1129	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MH791414	UNVERIFIED: Aeromonas phage Aswh_1, complete genome	168939-168966	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NC_023688	Aeromonas phage PX29, complete genome	94357-94384	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	KX925554	Streptomyces phage BRock, complete genome	101256-101283	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	CP015514	Vibrio vulnificus strain FORC_036 plasmid unnamed, complete sequence	661394-661421	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	CP015514	Vibrio vulnificus strain FORC_036 plasmid unnamed, complete sequence	661651-661678	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NZ_AP022849	Bosea sp. ANAM02 plasmid pANAM02, complete sequence	413564-413591	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MF140414	Mycobacterium phage Krypton555, complete genome	42636-42663	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MN871440	UNVERIFIED: Aeromonas phage AsFcp_1, complete genome	164086-164113	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NC_022052	Mycobacterium phage Whirlwind, complete genome	42215-42242	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NZ_MF600313	Mycolicibacterium sp. CBMA 213 plasmid pCBMA213_1, complete sequence	246945-246972	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MT133560	Pseudomonas phage fnug, complete genome	271452-271479	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MK599315	Pseudomonas phage PA1C, complete genome	298305-298332	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	KU521356	Pseudomonas phage KTN4, complete genome	272023-272050	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MW057919	Pseudomonas phage vB_PaeM_kmuB, complete genome	259027-259054	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NC_004629	Pseudomonas phage phiKZ, complete genome	272882-272909	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	334599-334626	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	334839-334866	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MN871480	UNVERIFIED: Pseudomonas phage PaSz-1_45_270k, complete genome	11927-11954	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	DI373487	KR 1020130142837-A/1: Bacteriophage of Pseudomonas aeruginosa and uses thereof	36076-36103	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MN871489	UNVERIFIED: Pseudomonas phage PaZh_1, complete genome	43887-43914	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NC_042060	Pseudomonas phage PA7, partial genome	36076-36103	5	0.821
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	AP019418	Pseudomonas phage PA02 DNA, nearly complete genome	231137-231164	5	0.821
NC_008578_1	1.1\|40655\|31\|NC_008578\|CRISPRCasFinder	40655-40685	31	NZ_LR134469	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 27, complete sequence	143599-143629	6	0.806
NC_008578_17	17.3\|2208773\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2208773-2208800	28	NZ_CP028970	Aminobacter sp. MSH1 plasmid pUSP2, complete sequence	186393-186420	6	0.786
NC_008578_17	17.3\|2208773\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2208773-2208800	28	NZ_CP006368	Aureimonas sp. AU20 plasmid pAU20a, complete sequence	414019-414046	6	0.786
NC_008578_17	17.9\|2209156\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209156-2209183	28	NC_019763	Oscillatoria nigro-viridis PCC 7112 plasmid pOSC7112.01, complete sequence	92022-92049	6	0.786
NC_008578_17	17.9\|2209156\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209156-2209183	28	NC_019731	Oscillatoria nigro-viridis PCC 7112 plasmid pOSC7112.03, complete sequence	64733-64760	6	0.786
NC_008578_17	17.9\|2209156\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209156-2209183	28	CP008939	Candidatus Caedibacter acanthamoebae plasmid Plasmid_00003, complete sequence	20991-21018	6	0.786
NC_008578_17	17.10\|2209220\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209220-2209247	28	NC_019763	Oscillatoria nigro-viridis PCC 7112 plasmid pOSC7112.01, complete sequence	92022-92049	6	0.786
NC_008578_17	17.10\|2209220\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209220-2209247	28	NC_019731	Oscillatoria nigro-viridis PCC 7112 plasmid pOSC7112.03, complete sequence	64733-64760	6	0.786
NC_008578_17	17.10\|2209220\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209220-2209247	28	CP008939	Candidatus Caedibacter acanthamoebae plasmid Plasmid_00003, complete sequence	20991-21018	6	0.786
NC_008578_17	17.11\|2209284\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209284-2209311	28	NZ_CP030828	Neorhizobium sp. NCHU2750 plasmid pNCHU2750a, complete sequence	539538-539565	6	0.786
NC_008578_17	17.15\|2209540\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209540-2209567	28	NZ_CP017244	Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence	153528-153555	6	0.786
NC_008578_17	17.16\|2209604\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209604-2209631	28	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	922207-922234	6	0.786
NC_008578_17	17.16\|2209604\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209604-2209631	28	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	457584-457611	6	0.786
NC_008578_17	17.16\|2209604\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209604-2209631	28	NZ_LR134454	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 12, complete sequence	36926-36953	6	0.786
NC_008578_17	17.16\|2209604\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209604-2209631	28	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	125017-125044	6	0.786
NC_008578_17	17.19\|2209796\|29\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209796-2209824	29	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	480576-480604	6	0.793
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NZ_CP033873	Caulobacter sp. FWC26 plasmid p1, complete sequence	35091-35118	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NZ_CP013298	Arthrobacter sp. YC-RL1 plasmid unnamed 1, complete sequence	86286-86313	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NZ_CP028348	Novosphingobium sp. THN1 plasmid pTHN, complete sequence	38414-38441	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NZ_CP031166	Euzebya sp. DY32-46 plasmid pEDY32-46I, complete sequence	347985-348012	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NZ_CP044308	Escherichia coli strain C27A plasmid pC27A-3, complete sequence	75795-75822	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	152309-152336	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	AY266303	Bacteriophage Aeh1, complete genome	96394-96421	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NC_005260	Aeromonas phage Aeh1, complete genome	96394-96421	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	480204-480231	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MN966730	Vibrio phage Cilsick, complete genome	73687-73714	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MT460515	Vibrio phage Cody, complete genome	73135-73162	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MT460514	Vibrio phage AG74, complete genome	72568-72595	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MH153812	Rhodococcus phage Grayson, complete genome	79810-79837	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MN966731	Vibrio phage Chazly21, complete genome	73827-73854	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MT460517	Vibrio phage Athena, complete genome	73089-73116	6	0.786
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MN966732	Vibrio phage Chester, complete genome	73693-73720	6	0.786
NC_008578_16	16.1\|2120274\|33\|NC_008578\|CRISPRCasFinder	2120274-2120306	33	MF403005	Agrobacterium phage Atu_ph02, complete genome	39670-39702	7	0.788
NC_008578_17	17.4\|2208837\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2208837-2208864	28	NZ_CP017664	Cronobacter sp. JZ38 plasmid unnamed2, complete sequence	95097-95124	7	0.75
NC_008578_17	17.4\|2208837\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2208837-2208864	28	NZ_CP012267	Cronobacter dublinensis subsp. dublinensis LMG 23823 plasmid pCDU1, complete sequence	123727-123754	7	0.75
NC_008578_17	17.6\|2208964\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2208964-2208991	28	NC_011368	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence	886677-886704	7	0.75
NC_008578_17	17.8\|2209092\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209092-2209119	28	MH834594	Arthrobacter phage Adaia, complete genome	12735-12762	7	0.75
NC_008578_17	17.8\|2209092\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209092-2209119	28	CP041325	Planomicrobium glaciei strain 46093 plasmid unnamed1, complete sequence	35250-35277	7	0.75
NC_008578_17	17.8\|2209092\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209092-2209119	28	CP041325	Planomicrobium glaciei strain 46093 plasmid unnamed1, complete sequence	143715-143742	7	0.75
NC_008578_17	17.13\|2209412\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209412-2209439	28	NZ_CP047143	Lactobacillus sp. C25 plasmid unnamed, complete sequence	19818-19845	7	0.75
NC_008578_17	17.14\|2209476\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209476-2209503	28	MH576962	Streptomyces phage Satis, complete genome	104713-104740	7	0.75
NC_008578_17	17.14\|2209476\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209476-2209503	28	MK620894	Streptomyces phage Kradal, complete genome	104717-104744	7	0.75
NC_008578_17	17.18\|2209732\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209732-2209759	28	NZ_CP028969	Aminobacter sp. MSH1 plasmid pUSP1, complete sequence	274550-274577	7	0.75
NC_008578_17	17.18\|2209732\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209732-2209759	28	NZ_CP026266	Aminobacter sp. MSH1 plasmid pAM01, complete sequence	271827-271854	7	0.75
NC_008578_17	17.19\|2209796\|29\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209796-2209824	29	NZ_CP020440	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed2, complete sequence	109864-109892	7	0.759
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NC_023688	Aeromonas phage PX29, complete genome	83784-83811	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MN871440	UNVERIFIED: Aeromonas phage AsFcp_1, complete genome	174892-174919	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MT661596	Proteus phage 10, complete genome	124494-124521	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MH791407	UNVERIFIED: Aeromonas phage AsFcp_4, partial genome	208552-208579	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MH791401	UNVERIFIED: Aeromonas phage AsFcp_2, complete genome	32811-32838	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NZ_CP016463	Bosea sp. RAC05 plasmid pBSY19_1, complete sequence	459266-459293	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MH697579	Mycobacterium phage Cane17, complete genome	98383-98410	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MH051261	Mycobacterium phage Tyke, complete genome	98028-98055	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MT684598	Streptomyces phage Faust, complete genome	76854-76881	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	NC_005893	Lactobacillus phage phiAT3, complete genome	37027-37054	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	EU826471	Mycobacterium phage Cali, complete genome	97525-97552	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	KX721255	Mycobacterium phage Yucca, complete genome	97122-97149	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MF668280	Mycobacterium phage Phabba, complete genome	93876-93903	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MH910040	Mycobacterium phage Sauce, complete genome	95869-95896	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MK359308	Mycobacterium phage Shaqnato, complete genome	95315-95342	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	AY605066	Bacteriophage phi AT3, complete sequence	37027-37054	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MK359355	Mycobacterium phage Sprinklers, complete genome	96096-96123	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MN062707	Mycobacterium phage Grungle, complete genome	94468-94495	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	GQ303260	Mycobacterium phage ET08, complete genome	96008-96035	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	KC748968	Mycobacterium phage Gizmo, complete genome	98507-98534	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MT553335	Mycobacterium phage Ronan, complete genome	94853-94880	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MF919513	Mycobacterium phage Koguma, complete genome	94764-94791	7	0.75
NC_008578_17	17.23\|2210053\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2210053-2210080	28	MK450423	Mycobacterium phage Stubby, complete genome	95312-95339	7	0.75
NC_008578_1	1.1\|40655\|31\|NC_008578\|CRISPRCasFinder	40655-40685	31	NZ_CP014519	Sinomonas atrocyanea strain KCTC 3377 plasmid pSA01, complete sequence	23204-23234	8	0.742
NC_008578_1	1.1\|40655\|31\|NC_008578\|CRISPRCasFinder	40655-40685	31	NZ_CP039340	Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence	1155584-1155614	8	0.742
NC_008578_1	1.1\|40655\|31\|NC_008578\|CRISPRCasFinder	40655-40685	31	NZ_CP021355	Rhodococcus sp. S2-17 plasmid pRB98, complete sequence	807445-807475	8	0.742
NC_008578_9	9.1\|1654518\|34\|NC_008578\|CRISPRCasFinder	1654518-1654551	34	NC_013856	Azospirillum sp. B510 plasmid pAB510b, complete sequence	281430-281463	8	0.765
NC_008578_17	17.3\|2208773\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2208773-2208800	28	NZ_CP023526	Cedecea neteri strain FDAARGOS_392 plasmid unnamed, complete sequence	116644-116671	8	0.714
NC_008578_17	17.17\|2209668\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209668-2209695	28	NZ_AP022566	Mycolicibacterium alvei strain JCM 12272 plasmid pJCM12272, complete sequence	195530-195557	8	0.714
NC_008578_17	17.18\|2209732\|28\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209732-2209759	28	NZ_AP014706	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_2p, complete sequence	199920-199947	8	0.714
NC_008578_17	17.19\|2209796\|29\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209796-2209824	29	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	149873-149901	8	0.724
NC_008578_17	17.19\|2209796\|29\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209796-2209824	29	NC_010553	Burkholderia ambifaria MC40-6 plasmid pBMC401, complete sequence	28062-28090	8	0.724
NC_008578_17	17.19\|2209796\|29\|NC_008578\|CRISPRCasFinder,CRT,PILER-CR	2209796-2209824	29	NZ_CP015231	Epibacterium mobile F1926 plasmid unnamed1, complete sequence	1129993-1130021	8	0.724
NC_008578_1	1.1\|40655\|31\|NC_008578\|CRISPRCasFinder	40655-40685	31	NC_000958	Deinococcus radiodurans R1 plasmid MP1, complete sequence	29238-29268	9	0.71
NC_008578_1	1.1\|40655\|31\|NC_008578\|CRISPRCasFinder	40655-40685	31	NZ_CP050118	Deinococcus radiodurans strain BNK-50 plasmid pMP1, complete sequence	172593-172623	9	0.71
NC_008578_1	1.1\|40655\|31\|NC_008578\|CRISPRCasFinder	40655-40685	31	NZ_CP050122	Deinococcus radiodurans strain BND-54 plasmid pMP1, complete sequence	117092-117122	9	0.71
NC_008578_1	1.1\|40655\|31\|NC_008578\|CRISPRCasFinder	40655-40685	31	NC_015583	Novosphingobium sp. PP1Y plasmid Mpl, complete sequence	322239-322269	9	0.71
NC_008578_1	1.1\|40655\|31\|NC_008578\|CRISPRCasFinder	40655-40685	31	NZ_CP031502	Deinococcus radiodurans strain R1 dM1 plasmid pMP1, complete sequence	127654-127684	9	0.71
NC_008578_8	8.2\|1548010\|36\|NC_008578\|CRISPRCasFinder	1548010-1548045	36	MH271298	Microbacterium phage Floof, complete genome	38349-38384	9	0.75
NC_008578_3	3.1\|561096\|35\|NC_008578\|CRISPRCasFinder	561096-561130	35	NC_015060	Granulicella tundricola MP5ACTX9 plasmid pACIX905, complete sequence	112148-112182	11	0.686

1. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MF140413 (Mycobacterium phage Kingsolomon, complete genome) position: , mismatch: 3, identity: 0.893

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgaccaccggt	Protospacer
*********.************* ***

2. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MK878900 (Mycobacterium phage MsGreen, complete genome) position: , mismatch: 3, identity: 0.893

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgaccaccggt	Protospacer
*********.************* ***

3. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to KT372003 (Mycobacterium phage Lumos, complete genome) position: , mismatch: 3, identity: 0.893

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgaccaccggt	Protospacer
*********.************* ***

4. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MT889391 (Mycobacterium phage MiniMac, complete genome) position: , mismatch: 3, identity: 0.893

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgaccaccggt	Protospacer
*********.************* ***

5. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MK494099 (Mycobacterium phage Typha, complete genome) position: , mismatch: 3, identity: 0.893

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggcgggacttgaacccgcgacctacgga	Protospacer
.********************* .****

6. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MH727559 (Mycobacterium phage Samty, complete genome) position: , mismatch: 3, identity: 0.893

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgaccaccggt	Protospacer
*********.************* ***

7. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MF140405 (Mycobacterium phage Clautastrophe, complete genome) position: , mismatch: 3, identity: 0.893

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgaccaccggt	Protospacer
*********.************* ***

8. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MT889383 (Mycobacterium phage MiniLon, complete genome) position: , mismatch: 3, identity: 0.893

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgaccaccggt	Protospacer
*********.************* ***

9. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to KT281791 (Mycobacterium phage Lolly9, complete genome) position: , mismatch: 3, identity: 0.893

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgaccaccggt	Protospacer
*********.************* ***

10. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MN096377 (Mycobacterium phage Finnry, complete genome) position: , mismatch: 3, identity: 0.893

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgaccaccggt	Protospacer
*********.************* ***

11. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_028778 (Mycobacterium phage Snenia, complete genome) position: , mismatch: 3, identity: 0.893

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgaccaccggt	Protospacer
*********.************* ***

12. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MF140421 (Mycobacterium phage Nicholas, complete genome) position: , mismatch: 3, identity: 0.893

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgaccaccggt	Protospacer
*********.************* ***

13. spacer 4.1|641398|26|NC_008578|CRISPRCasFinder matches to NZ_CP021016 (Xanthomonas citri pv. phaseoli var. fuscans strain CFBP6991 plasmid pF, complete sequence) position: , mismatch: 4, identity: 0.846

ggcggcgtggagaagccgcggttgca	CRISPR spacer
cacagcgtggagaaggcgcggttgca	Protospacer
 .*.*********** **********

14. spacer 4.1|641398|26|NC_008578|CRISPRCasFinder matches to NZ_CP020890 (Xanthomonas citri pv. citri strain TX160197 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.846

ggcggcgtggagaagccgcggttgca	CRISPR spacer
cacagcgtggagaaggcgcggttgca	Protospacer
 .*.*********** **********

15. spacer 4.1|641398|26|NC_008578|CRISPRCasFinder matches to NZ_CP020883 (Xanthomonas citri pv. citri strain TX160042 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.846

ggcggcgtggagaagccgcggttgca	CRISPR spacer
cacagcgtggagaaggcgcggttgca	Protospacer
 .*.*********** **********

16. spacer 4.1|641398|26|NC_008578|CRISPRCasFinder matches to NZ_CP020886 (Xanthomonas citri pv. citri strain TX160149 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.846

ggcggcgtggagaagccgcggttgca	CRISPR spacer
cacagcgtggagaaggcgcggttgca	Protospacer
 .*.*********** **********

17. spacer 17.16|2209604|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP032325 (Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence) position: , mismatch: 4, identity: 0.857

cgcccgcgccgcctgagc---tggtcgaatt	CRISPR spacer
cgcccgcgccgcctgagccggtggccga---	Protospacer
******************   ***.***

18. spacer 17.16|2209604|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_022061 (Mycobacterium phage KayaCho, complete genome) position: , mismatch: 4, identity: 0.857

cgcccgcgccgcctgagctgg--tcgaatt	CRISPR spacer
cgcccgcgccgcccgagctggccccgaa--	Protospacer
*************.*******  .****

19. spacer 17.16|2209604|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to KJ433975 (Mycobacterium phage 40BC, complete genome) position: , mismatch: 4, identity: 0.857

cgcccgcgccgcctgagctgg--tcgaatt	CRISPR spacer
cgcccgcgccgcccgagctggccccgaa--	Protospacer
*************.*******  .****

20. spacer 17.16|2209604|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to KJ433973 (Mycobacterium phage 39HC, complete genome) position: , mismatch: 4, identity: 0.857

cgcccgcgccgcctgagctgg--tcgaatt	CRISPR spacer
cgcccgcgccgcccgagctggccccgaa--	Protospacer
*************.*******  .****

21. spacer 17.16|2209604|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_024145 (Mycobacterium phage Hosp, complete genome) position: , mismatch: 4, identity: 0.857

cgcccgcgccgcctgagctgg--tcgaatt	CRISPR spacer
cgcccgcgccgcccgagctggccccgaa--	Protospacer
*************.*******  .****

22. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to HQ316582 (Vibrio phage henriette 12B8, complete genome) position: , mismatch: 4, identity: 0.857

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
tgcgggactcgaacccgcgaccagccaa	Protospacer
 ********.*************** .*

23. spacer 1.1|40655|31|NC_008578|CRISPRCasFinder matches to NZ_CP032348 (Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence) position: , mismatch: 5, identity: 0.839

cggtcgtgccggccgggcgcccgc-ggcgtat	CRISPR spacer
tggtcctgccgtccgggcgcccgctggccta-	Protospacer
.**** ***** ************ *** **

24. spacer 17.16|2209604|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 5, identity: 0.821

cgcccgcgccgcctgagctggtcgaatt	CRISPR spacer
cccaggcgccgcctgagctggccgaagt	Protospacer
* *  ****************.**** *

25. spacer 17.19|2209796|29|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to LN997843 (Streptomyces reticuli genome assembly TUE45, plasmid : II) position: , mismatch: 5, identity: 0.828

ccacccggccaccgtagcgcgcggcggag	CRISPR spacer
ctacccgcccaccggagcgcgcggccggg	Protospacer
*.***** ****** ********** *.*

26. spacer 17.21|2209925|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP022992 (Paraburkholderia aromaticivorans strain BN5 plasmid pBN2, complete sequence) position: , mismatch: 5, identity: 0.821

ccgaccgagcgaaacgcccggtgcgaga	CRISPR spacer
cgaaccgggcgagacgcccggtgcgagg	Protospacer
* .****.****.**************.

27. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MH595538 (Vibrio phage BONAISHI, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggacttgaacccgcgaccaacgac	Protospacer
..*********************.**.

28. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MT354569 (Pseudomonas phage phiK7B1, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggacttgaacccgcgacctctcgc	Protospacer
**********************  . *

29. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MH791414 (UNVERIFIED: Aeromonas phage Aswh_1, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggactcgaacccgcgaccaacggg	Protospacer
..*******.*************.***.

30. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_023688 (Aeromonas phage PX29, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gactggacttgaaccagtgaccagcgga	Protospacer
..* *********** *.**********

31. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to KX925554 (Streptomyces phage BRock, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
tgagggacttgaacccccgaccatcggc	Protospacer
 * ************* ****** ***

32. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to CP015514 (Vibrio vulnificus strain FORC_036 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggagggagttgaacccccgaccagcggg	Protospacer
.* **** ******** **********.

33. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to CP015514 (Vibrio vulnificus strain FORC_036 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggagggagttgaacccccgaccagcggg	Protospacer
.* **** ******** **********.

34. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP022849 (Bosea sp. ANAM02 plasmid pANAM02, complete sequence) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgacctaacga	Protospacer
*********.************ .  **

35. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MF140414 (Mycobacterium phage Krypton555, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggcgggatttgaacccgcgacccgcagt	Protospacer
.******.************** **.*

36. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MN871440 (UNVERIFIED: Aeromonas phage AsFcp_1, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gactggacttgaaccagtgaccagcgga	Protospacer
..* *********** *.**********

37. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_022052 (Mycobacterium phage Whirlwind, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggcgggatttgaacccgcgacccgcagt	Protospacer
.******.************** **.*

38. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_MF600313 (Mycolicibacterium sp. CBMA 213 plasmid pCBMA213_1, complete sequence) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggcgggacttgaacccgcggccgccgca	Protospacer
.******************.**. ** *

39. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MT133560 (Pseudomonas phage fnug, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcaggacttgaacctgcgaccaagcga	Protospacer
***.***********.*******.  **

40. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MK599315 (Pseudomonas phage PA1C, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcaggacttgaacctgcgaccaagcga	Protospacer
***.***********.*******.  **

41. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to KU521356 (Pseudomonas phage KTN4, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcaggacttgaacctgcgaccaagcga	Protospacer
***.***********.*******.  **

42. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MW057919 (Pseudomonas phage vB_PaeM_kmuB, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcaggacttgaacctgcgaccaagcga	Protospacer
***.***********.*******.  **

43. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_004629 (Pseudomonas phage phiKZ, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcaggacttgaacctgcgaccaagcga	Protospacer
***.***********.*******.  **

44. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggcgggactcgaacccgcgacctcctga	Protospacer
.********.************  * **

45. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggcgggactcgaacccgcgacctcctga	Protospacer
.********.************  * **

46. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MN871480 (UNVERIFIED: Pseudomonas phage PaSz-1_45_270k, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcaggacttgaacctgcgaccaagcga	Protospacer
***.***********.*******.  **

47. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to DI373487 (KR 1020130142837-A/1: Bacteriophage of Pseudomonas aeruginosa and uses thereof) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcaggacttgaacctgcgaccaagcga	Protospacer
***.***********.*******.  **

48. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MN871489 (UNVERIFIED: Pseudomonas phage PaZh_1, complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcaggacttgaacctgcgaccaagcga	Protospacer
***.***********.*******.  **

49. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_042060 (Pseudomonas phage PA7, partial genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcaggacttgaacctgcgaccaagcga	Protospacer
***.***********.*******.  **

50. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to AP019418 (Pseudomonas phage PA02 DNA, nearly complete genome) position: , mismatch: 5, identity: 0.821

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcaggacttgaacctgcgaccaagcga	Protospacer
***.***********.*******.  **

51. spacer 1.1|40655|31|NC_008578|CRISPRCasFinder matches to NZ_LR134469 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 27, complete sequence) position: , mismatch: 6, identity: 0.806

--cggtcgtgccggccgggcgcccgcggcgtat	CRISPR spacer
atcgg--gtgccggccggccgcgcgcggcgggt	Protospacer
  ***  *********** *** ******* .*

52. spacer 17.3|2208773|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP028970 (Aminobacter sp. MSH1 plasmid pUSP2, complete sequence) position: , mismatch: 6, identity: 0.786

aaagcacggcgggctgccggcctcaccc	CRISPR spacer
ggagctcggcgggcggccggcctcatct	Protospacer
..*** ******** **********.*.

53. spacer 17.3|2208773|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP006368 (Aureimonas sp. AU20 plasmid pAU20a, complete sequence) position: , mismatch: 6, identity: 0.786

aaagcacggcgggctgccggcctcaccc	CRISPR spacer
gaaggacggcgcgctgccggcctctatc	Protospacer
.*** ****** ************  .*

54. spacer 17.9|2209156|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_019763 (Oscillatoria nigro-viridis PCC 7112 plasmid pOSC7112.01, complete sequence) position: , mismatch: 6, identity: 0.786

gcagattgatgctaaagctggggagatt	CRISPR spacer
cgagattgatgctaaaactggggatttg	Protospacer
  **************.*******  *

55. spacer 17.9|2209156|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_019731 (Oscillatoria nigro-viridis PCC 7112 plasmid pOSC7112.03, complete sequence) position: , mismatch: 6, identity: 0.786

gcagattgatgctaaagctggggagatt	CRISPR spacer
cgagattgatgctaaaactggggatttg	Protospacer
  **************.*******  *

56. spacer 17.9|2209156|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to CP008939 (Candidatus Caedibacter acanthamoebae plasmid Plasmid_00003, complete sequence) position: , mismatch: 6, identity: 0.786

gcagattgatgctaaagctggggagatt	CRISPR spacer
tccattttatgctaaagctggggggatt	Protospacer
 * . ** ***************.****

57. spacer 17.10|2209220|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_019763 (Oscillatoria nigro-viridis PCC 7112 plasmid pOSC7112.01, complete sequence) position: , mismatch: 6, identity: 0.786

gcagattgatgctaaagctggggagatt	CRISPR spacer
cgagattgatgctaaaactggggatttg	Protospacer
  **************.*******  *

58. spacer 17.10|2209220|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_019731 (Oscillatoria nigro-viridis PCC 7112 plasmid pOSC7112.03, complete sequence) position: , mismatch: 6, identity: 0.786

gcagattgatgctaaagctggggagatt	CRISPR spacer
cgagattgatgctaaaactggggatttg	Protospacer
  **************.*******  *

59. spacer 17.10|2209220|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to CP008939 (Candidatus Caedibacter acanthamoebae plasmid Plasmid_00003, complete sequence) position: , mismatch: 6, identity: 0.786

gcagattgatgctaaagctggggagatt	CRISPR spacer
tccattttatgctaaagctggggggatt	Protospacer
 * . ** ***************.****

60. spacer 17.11|2209284|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP030828 (Neorhizobium sp. NCHU2750 plasmid pNCHU2750a, complete sequence) position: , mismatch: 6, identity: 0.786

ctccgggtggtattcccgccgggacctg	CRISPR spacer
ctctgggtggtattcccgacgggaagat	Protospacer
***.************** *****

61. spacer 17.15|2209540|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017244 (Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence) position: , mismatch: 6, identity: 0.786

agatccttgagtgcgtgcccggtgccgc	CRISPR spacer
ggatacttgagggcgtgcccggtgtgcc	Protospacer
.*** ****** ************.  *

62. spacer 17.16|2209604|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 6, identity: 0.786

cgcccgcgccgcctgagctggtcgaatt	CRISPR spacer
ggcccgcgccgcttgcgctggtcggcat	Protospacer
 ***********.** ********.  *

63. spacer 17.16|2209604|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 6, identity: 0.786

cgcccgcgccgcctgagctggtcgaatt	CRISPR spacer
cgcccgcgccgcctgatccggtcctacg	Protospacer
**************** *.****  *.

64. spacer 17.16|2209604|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_LR134454 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 12, complete sequence) position: , mismatch: 6, identity: 0.786

cgcccgcgccgcctgagctggtcgaatt	CRISPR spacer
tgggggcgccgcccgagccggtcgaatt	Protospacer
.*   ********.****.*********

65. spacer 17.16|2209604|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 6, identity: 0.786

cgcccgcgccgcctgagctggtcgaatt	CRISPR spacer
ggcccgcgccgcttgcgctggtcggcat	Protospacer
 ***********.** ********.  *

66. spacer 17.19|2209796|29|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 6, identity: 0.793

ccacccggccaccgtagcgcgcggcggag	CRISPR spacer
ggaacaggccgccgtagcgcgcggcggtg	Protospacer
  * * ****.**************** *

67. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP033873 (Caulobacter sp. FWC26 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggcgggacttgaacccgcgacctccctg	Protospacer
.*********************  *  .

68. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP013298 (Arthrobacter sp. YC-RL1 plasmid unnamed 1, complete sequence) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggacttgaacccgcgacctccgcc	Protospacer
..********************  **

69. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP028348 (Novosphingobium sp. THN1 plasmid pTHN, complete sequence) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggcgggatttgaacccgcgacctgcatc	Protospacer
.******.************** **.

70. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP031166 (Euzebya sp. DY32-46 plasmid pEDY32-46I, complete sequence) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggacttgaacccgcaaccaccgcg	Protospacer
..****************.**** ** .

71. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP044308 (Escherichia coli strain C27A plasmid pC27A-3, complete sequence) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggactcgaacccgcgacctgcgtg	Protospacer
..*******.************ *** .

72. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggcgggactcgaacccgcgacctggagc	Protospacer
.********.************ * .*

73. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to AY266303 (Bacteriophage Aeh1, complete genome) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggactcgaacccgcgaccaacagt	Protospacer
..*******.*************.*.*

74. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_005260 (Aeromonas phage Aeh1, complete genome) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggactcgaacccgcgaccaacagt	Protospacer
..*******.*************.*.*

75. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggcgggatttgaacccgcgacctctggg	Protospacer
.******.**************  .**.

76. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MN966730 (Vibrio phage Cilsick, complete genome) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
tgcgggactcgaacccgcgaccccctgc	Protospacer
 ********.************  * *

77. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MT460515 (Vibrio phage Cody, complete genome) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
tgcgggactcgaacccgcgaccccctgc	Protospacer
 ********.************  * *

78. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MT460514 (Vibrio phage AG74, complete genome) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
tgcgggactcgaacccgcgaccccctgc	Protospacer
 ********.************  * *

79. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MH153812 (Rhodococcus phage Grayson, complete genome) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
tgagggacttgaacccccgacccgcgac	Protospacer
 * ************* ***** ***.

80. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MN966731 (Vibrio phage Chazly21, complete genome) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
tgcgggactcgaacccgcgaccccctgc	Protospacer
 ********.************  * *

81. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MT460517 (Vibrio phage Athena, complete genome) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
tgcgggactcgaacccgcgaccccctgc	Protospacer
 ********.************  * *

82. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MN966732 (Vibrio phage Chester, complete genome) position: , mismatch: 6, identity: 0.786

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
tgcgggactcgaacccgcgaccccctgc	Protospacer
 ********.************  * *

83. spacer 16.1|2120274|33|NC_008578|CRISPRCasFinder matches to MF403005 (Agrobacterium phage Atu_ph02, complete genome) position: , mismatch: 7, identity: 0.788

tgagc-cgaaaagcgcatcggctgagccgagacg	CRISPR spacer
-gaccatgctaaccgcatcggctgagccaagacg	Protospacer
 ** * .*  ** ***************.*****

84. spacer 17.4|2208837|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017664 (Cronobacter sp. JZ38 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.75

cgcgtcagccgcggcacgattaccgtac	CRISPR spacer
gatgtcacccgcggcaccattaccgttg	Protospacer
 ..**** ********* ********

85. spacer 17.4|2208837|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP012267 (Cronobacter dublinensis subsp. dublinensis LMG 23823 plasmid pCDU1, complete sequence) position: , mismatch: 7, identity: 0.75

cgcgtcagccgcggcacgattaccgtac	CRISPR spacer
gatgtcacccgcggcaccattaccgttg	Protospacer
 ..**** ********* ********

86. spacer 17.6|2208964|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_011368 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence) position: , mismatch: 7, identity: 0.75

cgaccaacggaagatcgccgatatgata	CRISPR spacer
ggaccaacggatgatcgccgatgctttt	Protospacer
 ********** **********..  *

87. spacer 17.8|2209092|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MH834594 (Arthrobacter phage Adaia, complete genome) position: , mismatch: 7, identity: 0.75

atcggcttggtgcggaccggcgggtttt	CRISPR spacer
atcggcttggtgctgaccggcgtaaacg	Protospacer
************* ******** .  .

88. spacer 17.8|2209092|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to CP041325 (Planomicrobium glaciei strain 46093 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.75

atcggcttggtgcggaccggcgggtttt	CRISPR spacer
ttcggcttggtgctgaccggcgtcctga	Protospacer
 ************ ********  .*

89. spacer 17.8|2209092|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to CP041325 (Planomicrobium glaciei strain 46093 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.75

atcggcttggtgcggaccggcgggtttt	CRISPR spacer
ttcggcttggtgctgaccggcgtcctga	Protospacer
 ************ ********  .*

90. spacer 17.13|2209412|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP047143 (Lactobacillus sp. C25 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.75

gaaactgtgaaaaacggtgcctttgcca	CRISPR spacer
agcactgtgaaaaacggtgcttttttct	Protospacer
.. *****************.*** .*

91. spacer 17.14|2209476|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MH576962 (Streptomyces phage Satis, complete genome) position: , mismatch: 7, identity: 0.75

tccgcaccgtcgactcgtacgcctgcag	CRISPR spacer
ggcgcaccgtcgactggtacgccgagaa	Protospacer
  ************* ******* . *.

92. spacer 17.14|2209476|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MK620894 (Streptomyces phage Kradal, complete genome) position: , mismatch: 7, identity: 0.75

tccgcaccgtcgactcgtacgcctgcag	CRISPR spacer
ggcgcaccgtcgactggtacgccgagaa	Protospacer
  ************* ******* . *.

93. spacer 17.18|2209732|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP028969 (Aminobacter sp. MSH1 plasmid pUSP1, complete sequence) position: , mismatch: 7, identity: 0.75

gatcccacacccagcaccagaacgcgcg	CRISPR spacer
gcggccccacccagcaccagaacgccaa	Protospacer
*   ** ******************  .

94. spacer 17.18|2209732|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP026266 (Aminobacter sp. MSH1 plasmid pAM01, complete sequence) position: , mismatch: 7, identity: 0.75

gatcccacacccagcaccagaacgcgcg	CRISPR spacer
gcggccccacccagcaccagaacgccaa	Protospacer
*   ** ******************  .

95. spacer 17.19|2209796|29|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP020440 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.759

ccacccggccaccgtagcgcgcggcggag	CRISPR spacer
cgacccggccaccgtggcgcgcgccttgc	Protospacer
* *************.******* *  .

96. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_023688 (Aeromonas phage PX29, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggactcgaacccgcgaccaatagt	Protospacer
..*******.*************...*

97. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MN871440 (UNVERIFIED: Aeromonas phage AsFcp_1, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggactcgaacccgcgaccaatagt	Protospacer
..*******.*************...*

98. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MT661596 (Proteus phage 10, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggactcgaacccgcgacctctacc	Protospacer
*********.************  ..

99. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MH791407 (UNVERIFIED: Aeromonas phage AsFcp_4, partial genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggactcgaacccgcgaccaatagt	Protospacer
..*******.*************...*

100. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MH791401 (UNVERIFIED: Aeromonas phage AsFcp_2, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggactcgaacccgcgaccaatagt	Protospacer
..*******.*************...*

101. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP016463 (Bosea sp. RAC05 plasmid pBSY19_1, complete sequence) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacttcgagc	Protospacer
*******.*************.   .*

102. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MH697579 (Mycobacterium phage Cane17, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

103. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MH051261 (Mycobacterium phage Tyke, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

104. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MT684598 (Streptomyces phage Faust, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggacttgaacccgcaaccattgcg	Protospacer
..****************.**** .* .

105. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_005893 (Lactobacillus phage phiAT3, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggcgggacttgcacccgcgaccttggct	Protospacer
.********** **********   *

106. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to EU826471 (Mycobacterium phage Cali, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

107. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to KX721255 (Mycobacterium phage Yucca, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

108. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MF668280 (Mycobacterium phage Phabba, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
gacgggactcgaacccgcgaccaccctc	Protospacer
..*******.************* *

109. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MH910040 (Mycobacterium phage Sauce, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

110. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MK359308 (Mycobacterium phage Shaqnato, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

111. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to AY605066 (Bacteriophage phi AT3, complete sequence) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
ggcgggacttgcacccgcgaccttggct	Protospacer
.********** **********   *

112. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MK359355 (Mycobacterium phage Sprinklers, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

113. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MN062707 (Mycobacterium phage Grungle, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

114. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to GQ303260 (Mycobacterium phage ET08, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

115. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to KC748968 (Mycobacterium phage Gizmo, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

116. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MT553335 (Mycobacterium phage Ronan, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

117. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MF919513 (Mycobacterium phage Koguma, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

118. spacer 17.23|2210053|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to MK450423 (Mycobacterium phage Stubby, complete genome) position: , mismatch: 7, identity: 0.75

agcgggacttgaacccgcgaccagcgga	CRISPR spacer
agcgggatttgaacccgcgacgttcacg	Protospacer
*******.*************   *. .

119. spacer 1.1|40655|31|NC_008578|CRISPRCasFinder matches to NZ_CP014519 (Sinomonas atrocyanea strain KCTC 3377 plasmid pSA01, complete sequence) position: , mismatch: 8, identity: 0.742

cggtcgtgccggccgggcgcccgcggcgtat	CRISPR spacer
gcccggtgccggccgggcgcccgcggcctca	Protospacer
   . ********************** *

120. spacer 1.1|40655|31|NC_008578|CRISPRCasFinder matches to NZ_CP039340 (Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence) position: , mismatch: 8, identity: 0.742

cggtcgtgccggccgggcgcccgcggcgtat	CRISPR spacer
tgaccgggccggccgggcgcccgctgcgggc	Protospacer
.*..** ***************** *** ..

121. spacer 1.1|40655|31|NC_008578|CRISPRCasFinder matches to NZ_CP021355 (Rhodococcus sp. S2-17 plasmid pRB98, complete sequence) position: , mismatch: 8, identity: 0.742

cggtcgtgccggccgggcgcccgcggcgtat	CRISPR spacer
cgatcgtgccgggcgggcgcccgcctccctg	Protospacer
**.********* ***********  * .

122. spacer 9.1|1654518|34|NC_008578|CRISPRCasFinder matches to NC_013856 (Azospirillum sp. B510 plasmid pAB510b, complete sequence) position: , mismatch: 8, identity: 0.765

cgtgaggcgccagggaggcccgccgactcggtct---	CRISPR spacer
ggtgatgcgccagggatgcccgccg---ccgtccagc	Protospacer
 **** ********** ********   * ***.

123. spacer 17.3|2208773|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP023526 (Cedecea neteri strain FDAARGOS_392 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.714

aaagcacggcgggctgccggcctcaccc	CRISPR spacer
taagcacggcgtgctgccggccgtgggg	Protospacer
 ********** ********** ..

124. spacer 17.17|2209668|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP022566 (Mycolicibacterium alvei strain JCM 12272 plasmid pJCM12272, complete sequence) position: , mismatch: 8, identity: 0.714

tgctcgagcaccggtagcagctgtgtct	CRISPR spacer
ccgtcgagcaccgggagcagctgttgtg	Protospacer
.  *********** *********  .

125. spacer 17.18|2209732|28|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014706 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_2p, complete sequence) position: , mismatch: 8, identity: 0.714

gatcccacacccagcaccagaacgcgcg	CRISPR spacer
tgccccacacccagctccagaacgataa	Protospacer
 ..************ ********   .

126. spacer 17.19|2209796|29|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.724

ccacccggccaccgtagcgcgcggcggag	CRISPR spacer
ggggaaggccaccgtcgcgcgcggcggac	Protospacer
  .   ********* ************

127. spacer 17.19|2209796|29|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NC_010553 (Burkholderia ambifaria MC40-6 plasmid pBMC401, complete sequence) position: , mismatch: 8, identity: 0.724

ccacccggccaccgtagcgcgcggcggag	CRISPR spacer
gatcctggccaccgtcgcgcgcggcgcgc	Protospacer
   **.********* ********** .

128. spacer 17.19|2209796|29|NC_008578|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP015231 (Epibacterium mobile F1926 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.724

ccacccggccaccgtagcgcgcggcggag	CRISPR spacer
gggcgcggcgaccgtagcgcgcggcgagc	Protospacer
  .* **** ****************..

129. spacer 1.1|40655|31|NC_008578|CRISPRCasFinder matches to NC_000958 (Deinococcus radiodurans R1 plasmid MP1, complete sequence) position: , mismatch: 9, identity: 0.71

cggtcgtgccggccgggcgcccgcggcgtat	CRISPR spacer
ggccggtgcctgccgggcgcccggggcggcc	Protospacer
 * . ***** ************ ****  .

130. spacer 1.1|40655|31|NC_008578|CRISPRCasFinder matches to NZ_CP050118 (Deinococcus radiodurans strain BNK-50 plasmid pMP1, complete sequence) position: , mismatch: 9, identity: 0.71

cggtcgtgccggccgggcgcccgcggcgtat	CRISPR spacer
ggccggtgcctgccgggcgcccggggcggcc	Protospacer
 * . ***** ************ ****  .

131. spacer 1.1|40655|31|NC_008578|CRISPRCasFinder matches to NZ_CP050122 (Deinococcus radiodurans strain BND-54 plasmid pMP1, complete sequence) position: , mismatch: 9, identity: 0.71

cggtcgtgccggccgggcgcccgcggcgtat	CRISPR spacer
ggccggtgcctgccgggcgcccggggcggcc	Protospacer
 * . ***** ************ ****  .

132. spacer 1.1|40655|31|NC_008578|CRISPRCasFinder matches to NC_015583 (Novosphingobium sp. PP1Y plasmid Mpl, complete sequence) position: , mismatch: 9, identity: 0.71

cggtcgtgccggccgggcgcccgcggcgtat	CRISPR spacer
cggtcgcgccggccgggcacccggctggagc	Protospacer
******.***********.****    * ..

133. spacer 1.1|40655|31|NC_008578|CRISPRCasFinder matches to NZ_CP031502 (Deinococcus radiodurans strain R1 dM1 plasmid pMP1, complete sequence) position: , mismatch: 9, identity: 0.71

cggtcgtgccggccgggcgcccgcggcgtat	CRISPR spacer
ggccggtgcctgccgggcgcccggggcggcc	Protospacer
 * . ***** ************ ****  .

134. spacer 8.2|1548010|36|NC_008578|CRISPRCasFinder matches to MH271298 (Microbacterium phage Floof, complete genome) position: , mismatch: 9, identity: 0.75

catacgggcgccccacatccgcgcatcccacgagcc	CRISPR spacer
cgaggtcgcgccccacatccgcgcatcccaggacgc	Protospacer
*. .   *********************** **  *

135. spacer 3.1|561096|35|NC_008578|CRISPRCasFinder matches to NC_015060 (Granulicella tundricola MP5ACTX9 plasmid pACIX905, complete sequence) position: , mismatch: 11, identity: 0.686

gctcgtctcggcggtcgtttgtgagcccgtcggac	CRISPR spacer
tttgagactggcggtcgtttgtgagcccttctgag	Protospacer
 .* .  ..******************* ** **

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_008578

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection