CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_009475	Bradyrhizobium sp. BTAi1 plasmid pBBta01, complete sequence	0 crisprs	NA	0	0	1	0
NC_009485	Bradyrhizobium sp. BTAi1, complete sequence	1 crisprs	cas3,WYL,RT,csa3,DEDDh,cas9	0	0	6	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

105880 : 162525

Leptospira_phage(50.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148221383.1\|105880_107019_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.1e-32	34.8
WP_168167962.1\|107228_107390_-	hypothetical protein	NA	NA	NA	NA
WP_011931000.1\|107421_107835_-	DUF1622 domain-containing protein	NA	NA	NA	NA
WP_085972756.1\|107891_109154_-	OpgC domain-containing protein	NA	NA	NA	NA
WP_011931002.1\|109131_109806_-	hypothetical protein	NA	NA	NA	NA
WP_148221670.1\|110381_110708_-	hypothetical protein	NA	NA	NA	NA
WP_168167961.1\|110772_110940_+	hypothetical protein	NA	NA	NA	NA
WP_011931004.1\|111054_112419_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_011931005.1\|112646_113537_+	TIGR00730 family Rossman fold protein	F4YCQ1	Synechococcus_phage	9.0e-11	31.9
WP_041751817.1\|113928_114135_+	hypothetical protein	NA	NA	NA	NA
WP_011931007.1\|115402_116686_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_011931008.1\|117030_118578_-	glycogen synthase GlgA	NA	NA	NA	NA
WP_148221682.1\|119195_119789_+	periplasmic heavy metal sensor	NA	NA	NA	NA
WP_041751818.1\|119941_120151_-	hypothetical protein	NA	NA	NA	NA
WP_168167963.1\|120179_120347_-	hypothetical protein	NA	NA	NA	NA
WP_011931012.1\|121934_122186_+	hypothetical protein	NA	NA	NA	NA
WP_011931013.1\|122369_122906_+	hypothetical protein	NA	NA	NA	NA
WP_083780819.1\|123141_123603_-	four-helix bundle copper-binding protein	NA	NA	NA	NA
WP_148221671.1\|123754_125239_+	MFS transporter	NA	NA	NA	NA
WP_011931017.1\|125507_125906_-	copper-binding protein	NA	NA	NA	NA
WP_049795539.1\|126251_126620_+	hypothetical protein	NA	NA	NA	NA
WP_011931019.1\|126639_127680_-	hydrogenase expression/formation protein HypE	NA	NA	NA	NA
WP_041751865.1\|127676_129917_-	carbamoyltransferase HypF	NA	NA	NA	NA
WP_011931021.1\|129945_130458_-	HyaD/HybD family hydrogenase maturation endopeptidase	NA	NA	NA	NA
WP_011931022.1\|130454_131594_-	hydrogenase formation protein HypD	NA	NA	NA	NA
WP_011931023.1\|131590_132430_-	hydrogenase nickel incorporation protein HypB	NA	NA	NA	NA
WP_011931024.1\|132422_132860_-	hydrogenase maturation nickel metallochaperone HypA	NA	NA	NA	NA
WP_011931025.1\|132852_133092_-	HypC/HybG/HupF family hydrogenase formation chaperone	NA	NA	NA	NA
WP_011931026.1\|133121_134033_-	hypothetical protein	NA	NA	NA	NA
WP_083780820.1\|134029_135829_-	nickel-dependent hydrogenase large subunit	NA	NA	NA	NA
WP_011931028.1\|135812_136790_-	hydrogenase small subunit	NA	NA	NA	NA
WP_148221672.1\|136872_137193_-	hypothetical protein	NA	NA	NA	NA
WP_011931030.1\|138029_138452_+\|transposase	transposase	NA	NA	NA	NA
WP_011931031.1\|138445_138799_+	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_011931032.1\|138850_140413_+\|transposase	IS66-like element ISBrsp6 family transposase	A0A0P0ZEB3	Stx2-converting_phage	3.6e-87	38.0
WP_011931033.1\|140409_141012_+	plasmid pRiA4b ORF-3 family protein	NA	NA	NA	NA
WP_011931035.1\|141984_142767_-	copper resistance protein B	NA	NA	NA	NA
WP_011931036.1\|142776_144819_-	multicopper oxidase domain-containing protein	NA	NA	NA	NA
WP_011931038.1\|145080_145773_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_011931039.1\|145890_146667_-	cytochrome c3 family protein	NA	NA	NA	NA
WP_011931040.1\|146663_147368_-	iron reductase	NA	NA	NA	NA
WP_041751869.1\|147369_149085_-	2Fe-2S iron-sulfur cluster binding domain-containing protein	A0A0E3FC86	Synechococcus_phage	4.7e-08	36.1
WP_011931042.1\|149557_150244_-	Spy/CpxP family protein refolding chaperone	NA	NA	NA	NA
WP_011931043.1\|150474_152229_+	DUF3141 domain-containing protein	NA	NA	NA	NA
WP_041751824.1\|152614_152881_+	hypothetical protein	NA	NA	NA	NA
WP_011931045.1\|153528_155700_+	hypothetical protein	NA	NA	NA	NA
WP_011931047.1\|156101_156878_-	class III cytochrome C family protein	NA	NA	NA	NA
WP_011931048.1\|156874_157618_-	hypothetical protein	NA	NA	NA	NA
WP_148221673.1\|157620_158256_-	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_148221383.1\|158236_159374_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.1e-32	34.8
WP_011931051.1\|159750_160011_+	hypothetical protein	NA	NA	NA	NA
WP_011931052.1\|160133_161249_-	OpgC domain-containing protein	NA	NA	NA	NA
WP_148221383.1\|161387_162525_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.1e-32	34.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_009485

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CRISPR-Cas detection and classification

Crispr_ID: NC_009485_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009485_1

2309171-2309412

Orphan

Consensus_repeat	Method
GATCCCGACAATGACGGCACGCT	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_009485_1

>merge|NC_009485|1|2309171-2309412|CRISPRCasFinder
GACCCGGACAAGGACGGCACTGCCGACATGAACGAGGTTCGTGCCGCGGCGGGAGCACTGTTCGATCGTCTCGACCGCGATCATGATGGCACGCTCGATGCCAAGGAGCTCCGCGGCCGCGTGTCGGCCAAGGACCTGAAGGCTGCTGATCCCGACAATGACGGCACGCTGACCAAGGACGAATATCTCGCGCTGGTCGAGGGACGCTTCAAGGCCGCCGATCCCGACAATGACGGCACGCT

>NC_009485|1|1|2309171-2309412|CRISPRCasFinder
GACCCGGACAAGGACGGCACTGC	CGACATGAACGAGGTTCGTGCCGCGGCGGGAGCACTGTTCGATCGTCTC
GACCGCGATCATGATGGCACGCT	CGATGCCAAGGAGCTCCGCGGCCGCGTGTCGGCCAAGGACCTGAAGGCTGCT
GATCCCGACAATGACGGCACGCT	GACCAAGGACGAATATCTCGCGCTGGTCGAGGGACGCTTCAAGGCCGCC
GATCCCGACAATGACGGCACGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_009485.1\|WP_012042434.1\|2301995_2302325_+\|DUF2160-domain-containing-protein	unknown	unknown	gnl\|CDD\|378313
NC_009485.1\|WP_012042450.1\|2319782_2321021_-\|lytic-murein-transglycosylase	unknown	unknown	gnl\|CDD\|274067
NC_009485.1\|WP_012042448.1\|2318613_2319381_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187654
NC_009485.1\|WP_041750527.1\|2319525_2319756_-\|4-oxalocrotonate-tautomerase	unknown	unknown	gnl\|CDD\|179269
NC_009485.1\|WP_041751363.1\|2316802_2317216_+\|hypothetical-protein	unknown	unknown	unknown
NC_009485.1\|WP_012042432.1\|2300102_2301005_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_009485.1\|WP_012042452.1\|2323229_2324066_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NC_009485.1\|WP_148221599.1\|2313405_2316417_+\|autotransporter-domain-containing-protein	unknown	unknown	gnl\|CDD\|377133
NC_009485.1\|WP_012042444.1\|2310590_2312984_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|366183
NC_009485.1\|WP_012042443.1\|2309646_2310282_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_009485.1\|WP_012042441.1\|2308296_2308875_+\|hypothetical-protein	unknown	unknown	unknown
NC_009485.1\|WP_041750526.1\|2306728_2307070_-\|hypothetical-protein	unknown	unknown	unknown
NC_009485.1\|WP_012042438.1\|2305760_2306708_+\|TonB-family-protein	unknown	unknown	gnl\|CDD\|223880
NC_009485.1\|WP_012042435.1\|2302449_2304192_+\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NC_009485.1\|WP_012042437.1\|2305338_2305764_+\|TonB-system-transport-protein-ExbD	unknown	unknown	gnl\|CDD\|183064
NC_009485.1\|WP_012042436.1\|2304558_2305335_+\|tonB-system-energizer-ExbB	unknown	unknown	gnl\|CDD\|131844
NC_009485.1\|WP_012042440.1\|2307127_2307973_-\|hypothetical-protein	unknown	unknown	unknown
NC_009485.1\|WP_012042447.1\|2317298_2318396_-\|alkene-reductase	unknown	unknown	gnl\|CDD\|239243
NC_009485.1\|WP_012042451.1\|2321245_2322886_-\|alpha-D-glucose-phosphate-specific-phosphoglucomutase	unknown	unknown	gnl\|CDD\|236050
NC_009485.1\|WP_012042433.1\|2301004_2301811_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472

Protein	Function_ID	Function_description	E-value
NC_009485.1\|WP_012042434.1\|2301995_2302325_+\|DUF2160-domain-containing-protein	gnl\|CDD\|378313	pfam09928, DUF2160, Predicted small integral membrane protein (DUF2160). The members of this family of hypothetical prokaryotic proteins have no known function. It is thought that they are transmembrane proteins, but their function has not been inferred yet.	8.35082e-34
NC_009485.1\|WP_012042450.1\|2319782_2321021_-\|lytic-murein-transglycosylase	gnl\|CDD\|274067	TIGR02283, Membrane-bound_lytic_murein_transglycosylase_B, lytic murein transglycosylase. Members of this family are closely related to the MltB family lytic murein transglycosylases described by TIGR02282 and are likewise all proteobacterial, although that family and this one form clearly distinct clades. Several species have one member of each family. Many members of this family (unlike the MltB family) contain an additional C-terminal domain, a putative peptidoglycan binding domain (pfam01471), not included in region described by this model. Many sequences appear to contain N-terminal lipoprotein attachment sites, as does E. coli MltB in TIGR02282. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	6.43819e-140
NC_009485.1\|WP_012042448.1\|2318613_2319381_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187654	cd08951, DR_C-13_KR_SDR_c_like, daunorubicin C-13 ketoreductase (KR), classical (c)-like SDRs. Daunorubicin is a clinically important therapeutic compound used in some cancer treatments. Daunorubicin C-13 ketoreductase is member of the classical SDR family with a canonical glycine-rich NAD(P)-binding motif, but lacking a complete match to the active site tetrad characteristic of this group. The critical Tyr, plus the Lys and upstream Asn are present, but the catalytic Ser is replaced, generally by Gln. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type KRs have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	9.10263e-116
NC_009485.1\|WP_041750527.1\|2319525_2319756_-\|4-oxalocrotonate-tautomerase	gnl\|CDD\|179269	PRK01271, PRK01271, tautomerase PptA.	5.33535e-20
NC_009485.1\|WP_012042451.1\|2321245_2322886_-\|alpha-D-glucose-phosphate-specific-phosphoglucomutase	gnl\|CDD\|236050	PRK07564, PRK07564, phosphoglucomutase; Validated.	0
NC_009485.1\|WP_012042452.1\|2323229_2324066_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.000385114
NC_009485.1\|WP_148221599.1\|2313405_2316417_+\|autotransporter-domain-containing-protein	gnl\|CDD\|377133	pfam03797, Autotransporter, Autotransporter beta-domain. Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.	8.94481e-34
NC_009485.1\|WP_012042444.1\|2310590_2312984_+\|TonB-dependent-receptor	gnl\|CDD\|366183	pfam00593, TonB_dep_Rec, TonB dependent receptor. This model now only covers the conserved part of the barrel structure.	1.48367e-38
NC_009485.1\|WP_012042443.1\|2309646_2310282_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.22548e-42
NC_009485.1\|WP_012042432.1\|2300102_2301005_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.32107e-60
NC_009485.1\|WP_012042438.1\|2305760_2306708_+\|TonB-family-protein	gnl\|CDD\|223880	COG0810, TonB, Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane].	3.624e-11
NC_009485.1\|WP_012042435.1\|2302449_2304192_+\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	7.38864e-26
NC_009485.1\|WP_012042437.1\|2305338_2305764_+\|TonB-system-transport-protein-ExbD	gnl\|CDD\|183064	PRK11267, PRK11267, biopolymer transport protein ExbD; Provisional.	4.31935e-56
NC_009485.1\|WP_012042436.1\|2304558_2305335_+\|tonB-system-energizer-ExbB	gnl\|CDD\|131844	TIGR02797, Biopolymer_transport_protein_ExbB, tonB-system energizer ExbB. This model describes ExbB proteins, part of the MotA/TolQ/ExbB protein family. The paired proteins MotA and MotB, TolQ and TolR, and ExbB and ExbD harness the proton-motive force to drive the flagellar motor, energize the Tol-Pal system, or energize TonB, respectively. Tol-Pal and TonB are both active at the outer membrane. Genomes may have many different TonB-dependent receptors, of which many of those characterized are involved in siderophore transport across the outer membrane. [Transport and binding proteins, Cations and iron carrying compounds].	1.23527e-84
NC_009485.1\|WP_012042447.1\|2317298_2318396_-\|alkene-reductase	gnl\|CDD\|239243	cd02933, OYE_like_FMN, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include 12-oxophytodienoate reductase, pentaerythritol tetranitrate reductase, morphinone reductase, and related enzymes.	0
NC_009485.1\|WP_012042433.1\|2301004_2301811_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	7.2984e-67

>NC_009485.1|WP_012042441.1|2308296_2308875_+|hypothetical-protein
MHDRMHADSQISQRMEPPVLKAIVHRRRSSTPWGRLGAITILLLSFMLLSDGHAFAREQSLRDELEAWWKHSHTGTKAADKTCVTSEAGCTKRKIVRRRGAKATAADAAEAGGHVGRARRVSLGRAVLPAAQAKGGVDTMMHSGTQRRRAAKRGRDVAANSRGEARDAAGADLEMSPRRDRPGRYFLHGPRF
>NC_009485.1|WP_012042440.1|2307127_2307973_-|hypothetical-protein
MTTAALLLMPFGASAEEIQGNDPASPGHFQIEQRFGYVTTFNPQQQNGGQRVPQRAITGETEIGYSPTEWYEIALTSPYAFARANVPMTLGNVMDNGVPGYSFQSGGVTIRQTFIQGDRLERTVFLGLVSRTILAPQGGLTPDLWVANKAGAGQPGAPRFVQEATPRVAQMFTPIIGVNLPNDYQLIFNANMTFGIDGAGSAFEPSVRFVKRLNDRWTVGIEHFSNLGPIGHILPWNQQMQTLYAVADTKFKGFEFSFGVGYGLTNASRGLAVKTSIGKDF
>NC_009485.1|WP_041750526.1|2306728_2307070_-|hypothetical-protein
MRRLVTTCAVLMLAGSAAFAEDGPRFLNRTGQTIVKMYLAAAGTKSWGTDQCKNDDEGEVDHNERMTLVGVKSGRYDIKLADKAGRTCVAKNIELKEGAQFVVRDTDLTECSK
>NC_009485.1|WP_012042438.1|2305760_2306708_+|TonB-family-protein
MSVLTLDPFEDDERRERTLWTIAALVVAALHVGLAAGYLLLRPAAQGRAEAPAFDVVFTPAVVSDPAPAAQDAPPADPTPPVEPPKEEPVKEEPVAREAVAEPVPQPPPDPEPQVMAQPDPVPEVAPAPEPAPQVALAPEPPRVDDIVLPPPLPKPVEAKPPEQKPAPVPERVERKPVEKKETQEKAEKKPAPPKPAAAQASRPSRVASAPNPGEDSVGAREGQASWNAEVVAHIRRYVAYPSDGNGASGTAIVNVVIDRNGRLVSRRLAGSSGSPALDRAALSIIERAAPFPRFPPVMKQAQETRSVPLHMRPR
>NC_009485.1|WP_012042437.1|2305338_2305764_+|TonB-system-transport-protein-ExbD
MAVKLAKRPDEFEETHDINVTPFIDVMLVLLIIFMVAAPLATVDIPVNLPAISAEPQPRAETPVFVTFKADRSLAVGDQSVAQADIAASLDAATKSDHGQRVLLRADQTLPYGEVMALMNTLRRAGYTKVALVALEDRSVP
>NC_009485.1|WP_012042436.1|2304558_2305335_+|tonB-system-energizer-ExbB
MDQANIASLASTLPEALSPWTMFLQADMVVKAVMIGLALASVATWTVLVVKTIQLRAALRVARVALGTAVTAHSLANAAGSESAQEGVVGRLLAVAEDEIDKSRGLPADGIKERVAWQFERVEAAAVARIGRGIGILATVGAVAPFVGLFGTVWGIMNSFIGISHAHTTNLAVVAPGIAEALLATAFGLAAAIPAVVIYNLFARATGGYRAVIADASVAVMRLLSRDLDRQHAASTEARRGAIRAVDTSLLSIANPAE
>NC_009485.1|WP_012042435.1|2302449_2304192_+|carbohydrate-ABC-transporter-substrate-binding-protein
MTSAVALFAATMTLSAPARSDDATIQKWIDSEFQPSTLSKEEQLKELQWFAKAAEPFKGMEINVVSETITTHEYEAKTLAKAFSEITGIKLKHDIIQEGDVVEKLQTQMQSGKNVYDGWINDSDLIGTHFRYGQTIALSDYMKGEGKDVTDPYLDVNDFIGKSFTTAPDGKLYQLPDQQFANLYWFRYDWFTNPEYKAKFKAKYGYDLGVPVNWSAYEDIAEFFTNDIKEINGVKVYGHMDYGKKDPSLGWRFTDAWLSMAGNGDKGIPNGLPVDEWGIRMEGCRPVGSSVERGGDTNGPAAVYSITKYLEWMKKYAPPQAQGMTFSEAGPVPAQGNVAQQIFWYTAFTADMVKPGLPVVNADGTPKWRMAPSPHGAYWKEGMKLGYQDAGSLTLLKSTPPDRRKAAWLYLQFIVSKTVSLKKSHVGLTFIRESDIWDKSFTERAPKLGGLIEFYRSPARVQWTPTGNNVPDYPKLAQLWWQNIGDASSGAKTPQAAMDALAAAQDSVLERLEKSKVQGECGPKLNKKESAEFWFNKSAKDGNIAPQRKLANEKPKGETIDYDTLIKSWPASPPKRAEAK
>NC_009485.1|WP_012042434.1|2301995_2302325_+|DUF2160-domain-containing-protein
MDSIAWMAWTAPTAIFFVALACTLGVMTLLAARYPEAERVGVLRIPTTRGDRLFISLITAAVIHLAWIGLVGTDTIATLPIGEEGFEVSSLWLATAISLASAVAIFRTV
>NC_009485.1|WP_012042433.1|2301004_2301811_+|carbohydrate-ABC-transporter-permease
MNTIPGRRVIMAVFLVFLLLPIYWLVNMSFKTNNEIVTTMTLWPHQPTIANYMRIFTDESWYSGYINSLKYVILNTVISILVALPAAYAFSRYRFLGDKHLFFWLLSNRMAPAAVYALPFFNLYSAIGLFDTPWAVALAHCIFNIPLAVWILEGFVSSVPREIDETAFLDGYSFPRFFVKILVPLIASGIGVAAFFCFMFSWVELLLARTLTSVDAKPISAVMTRTVSASGMDWGLLAAAGVLTIIPGALVIWFVRNYIARGFALGRV
>NC_009485.1|WP_012042432.1|2300102_2301005_+|sugar-ABC-transporter-permease
MDKTINNKAWFLVLPVFLLVAFSAILPLMTVVNYSMQDTFGNNQFFWNGVGWFKELLDPSTDLGGRFLASLGRNLIFSLAILAIEVPLGIVVALSMPRDGWTVAFCLVVLALPLLIPWNVVGTIWQIFGRPDIGLLGYTLTSMGIDYNYVSNDLDAWATVIVMDVWHWTSLVALLCYAGLKSIPDAYYQAAQIDGASRWAVFTAIQLPKMHRVLLIAVLLRFMDSFMIYTEPFVVTGGGPGNSTTFISIELVKIALGQFDLGKAAALSLVYNLIILIVCWVFYTIMTNAGAERRPAEGGA
>NC_009485.1|WP_012042443.1|2309646_2310282_-|response-regulator-transcription-factor
MYRVLLVDDHPVVVAACRWLLSEAGIGELSEAHDAESAYEAFVRERPDAAVVDLRLQSQELGGIGLIQRMRSHDPGARILVFSMLADPRIVRSAIDAGASGYLLKDAPPHELPKALDQIRSGGTYLDPQLAKRIALLRKDADGTAATALTQRERQALALLGQAKSYQAIADQLGISYKTVINLTYRLRQKLGARSLPDLVRLAVEMSRPSL
>NC_009485.1|WP_012042444.1|2310590_2312984_+|TonB-dependent-receptor
MTRLSALKSALLATCALLPAAAFAQQTLQTIEVVGVAPVPGAEIDRDKVPSNVETIGARELDHSRAPSLLDNILRSVPGVSLSDQSGNAFQRNLDYRGATASPVPGTPQGIAVYQNGSRINEAFGDVVNWDLIPEMAIARMTLMPNNPLFGLNATGGALSIEMKNGFTYQGTEAQLWGGSYGRIQSGAQTGWTNGNVSAYVAAEGAYDRGWRDHSSSSQVRRMYADLGLRGDTTEFHLSFTGADNKLGSVAATPIEMLNQRWSSVYTWPQSTRLQLAFLQASAKWTPTDAWTVQANAYYRAYRASHVDGNGTEAQACDDNGAFPGEFCFQDDATGAEFPINRNSASVNNLPANTALGAIDRNWTKSNSYGGSLQAANTAQLFGHDNHFVVGSSVDHGRSNFQATSELGTVDGNFFVTGTGVFIDQPQANVAPVNLGAKNTYVGVYATDTFDITSQLAFTAGGRFNYAQINLQDETGLNPALNSRNNFQRFNPVVGFTYKFTPGLTAYAGYSEANRAPTPLELGCSDPANPCLIDNFLIADPPLKQVVSRTIEGGLRGEISGGRSAYAAVAPYRKAPPLVENDGWRLRWGISLFRTQNSDDIINVASLARPNAGYFTNAGTTLRQGVEAKVDLTWDRWAAYANYTFVDATFRSSFSVNDPNLQAVVAVTPGSHIPAIPAHRLKLGAEYAVTDAWKVGADMNYIGSQYLLRDEANTYPKVPAYWVVNLHTSYQVTKNVELFGMVQNLFNKRYYSAGTVFDPKGFNNSTEGAANLVTFNDPRSMLPGMPLAVYAGLKATF
>NC_009485.1|WP_148221599.1|2313405_2316417_+|autotransporter-domain-containing-protein
MTTGGAKAECTTPGVAVSCSGSITTAVTVYDAAAATATPASGSNAYTPANPAFPARGYNPNPPTAIITLDATANRTLVTNTQAGLADRGMIAANFSNAENPAVNNVVINNAGWLSLTTSQLSAGRLHVVVADSQVNRFTVNNTGTLAATQNVFSTFDPARLTVSTGATATARYNGTNLAIISALYSDDNTNSFVLNNRAGGTVSATGHFAAAYYGRAATIIANSGTIANTDWTAASRFYDGHWAIAAFAGAEFRTVAGSNPDTPLYAFDSNGNVTVSETKTLNLTNTAGGVIKGDILALDTNPLTTAAGRASGQAFPLTGSGSNSGPRDSVIANAGLIQGNLYLGSGAHNVTNSGTISGKIEVDQSASRGSFTKGIAGTAAGTFSSSGTGTDAGGRACPAAGTNTTDPLCAATTAQAASFSGARNFRLVNSGRLDGDITIIDQRGASNTILLRGTGFSGNVVARNGIGSNALTLDGVTSLASVVNFGMLDLMKSQVTVNSVNGVQLVDNAVLRTTIYGPGGTAAAPSTNLGNISGRLAFAGTGTIAPRLQGIVRDGDVYRVATSVSTAPLNVDFSGALVSFNADSTTGALLLKANVRSPASIAGLSPSSLAALDHLVGYRGGNAQLQALGGAVQSLRSDNEVRRAGDQLRPFVNGAQIEVPLATAALLQGQIDNRLTAAAAGASPNARVASAFADDTDPLTSVLLAFAPTKARPTLKAPAVVPEPERTVWGSLIGTNISQREVGGVAGYAGNTGGLVAGIDQRIGSASRIGAAFGYAASAMDDKTAAGDSVGIQHYQGTVYGAYVQPSWYVSGSAGVALLDYTTTRRIGFAGFADSVSGSHKGWLTVGRAELGVPVKVDQAVLTPFAGVAFAHLDQQGYTEASAAGAALTIAKQTTNSVRSNLGLRSMIPLLVTSTYGFGLETLAAWRHEFGNTAQTVTAGFAGGAGTFFAAGPSPTRDTAELGAALKLIAFGDRQSLSLGYNAVVGSAYLEQSAVLKVRAEF
>NC_009485.1|WP_041751363.1|2316802_2317216_+|hypothetical-protein
MASRRPTVLRRTLGAMALLILSAGLAMWCPLRCDATARDLDGRYANSPLKAWFESLRSAKGPCCSDADGTALSDIDWEMQDGRYRVRIEGLWWDVPEDAVVAGPNRAGRTMVWPVYYRQLDKVLRIEVRCFLPGSMT
>NC_009485.1|WP_012042447.1|2317298_2318396_-|alkene-reductase
MSTSKLFEPYKLGPITLANRAVMAPLTRNRAVEGLAAGPLTATYYAQRASAGLLISEASQVSQQGQGYQDTPGIYSKEQIAGWRKVTDAVHAKGGRIFIQLWHVGRISHVSLQPHGGAPVAPSAIAAKTKTFVGGAFTDVSAPRALELAEIPGIVQAFKQAALNAIEAGFDGVEIHGANGYLLDQFAKDGANKRTDAYGGSIENRARLMLEVAKAVSEAIGADKTGIRLSPVTPANDISDSNPQALFDYIVDQLNALKLVYIHVIEGATGGPRDVAPFDYASLRKRFKGTYIANNGYDLALANKQLDANAADLIAFGRPFIANPDLVERLKQNAPLNELDRATLYGGGAKGYTDYPTLQASQAAE
>NC_009485.1|WP_012042448.1|2318613_2319381_-|SDR-family-NAD(P)-dependent-oxidoreductase
MAIVFITGSADGLGRAAAQSLLDQGHRVVLHARSADRAAALGELGSRAAGIAVGDLRSAEETRRIADQVNAIGRMDAIIHNAGVYSQPDRGATPEGHATTLAINTLAPYVLTALIERPARLVYLSSGLHRGGEGSLTDLDWTTRPWDSAKAYAETKLHVVALALALARLWPEVLSNAVDPGWVQTRMGGTSAPVDIETGQRTQTWLAVSDDPEALVSGRYWHHLRQQEPAEEAVERTFQDKLIARLAELTGVTLP
>NC_009485.1|WP_041750527.1|2319525_2319756_-|4-oxalocrotonate-tautomerase
MPHVIVKLYPGRSEQQKQALARALTEAVTRTLNSGEDSVSVGIEDVTPNEWTAKVYRPDIIDKADTIYKKPGYDPQ
>NC_009485.1|WP_012042450.1|2319782_2321021_-|lytic-murein-transglycosylase
MAPEAAAPRPKPAPSMRAASCHNGQSFDRFLAELKQRAVAEGVSQRAIAAASPYLTYDQGIVNRDRGQRVFGQLFTEFAGRMAAVYRMQNGQQHIKMHAAAFARAEKDYGVPPAVIAAFWGLESDFGANMGNLPVLPSLVSLAYDCRRSERFQNETIAALKVIDRGDLSPTEMIGSWAGELGQTQFLPTHYVTYAVDYDGDGRRDLLRSAPDVIGSTANYIATGLKWRRGEPWLEEIRVPPTFPWEQADLTVKAPRSKWIGLGVTYADGRPLPNDALEASVLLPMGRNGPAFLAYANFAAYTEWNNSLIYSTTAAYLATRIAGAAPMRKASGPVAQLPFNEIKELQQLLVKAGFDVGKVDGVLGQQSRIAVKTMQLRLGLPADSWPTAELLARMRGNTPRAQAAPATTTATR
>NC_009485.1|WP_012042451.1|2321245_2322886_-|alpha-D-glucose-phosphate-specific-phosphoglucomutase
MAKIDPAAGKPLANAALANIPRLITAYYALKPDPHEPTQRVAFGTSGHRGSSLKTGFNENHILATTQALCDYRRQHGLDGPLFVGIDTHALAEPALASALEVFGANGVDVMVDKDGGYTPTPVISHAIIAYNKGRTEHLADGVVITPSHNPPEDGGYKYNPPHGGPADTDATGEIERQANIYLANELDGVSRISYTKARQRGSVHPYDYITPYVADLANTVDLDAIKAAGVKIGIDPLGGAAIAYGAPLIERYGLNATIVNDLVDPTFRFMTADWDGKIRMDCSSPYAMASLIGMRERFDVAFANDTDADRHGIVTRSGGLMNPNHYLATAISYLFAHRPDWRSDAAIGKTIVSSSLIDRVARKLGRKLVETPVGFKWFVEGLHSGSFGFAGEESAGASFLKRDGTVWTTDKDGLILGLLAAEIMARRGRDPSELYKELTSELGAPVYERIDVPASPPQKAALKALTPEQLNLTELAGDPVRVVHTKAPGNGQSFGGIKVETDYGWFAARPSGTEDVNKLYAESFRDAEHLKRIQSEAQAALAKVA
>NC_009485.1|WP_012042452.1|2323229_2324066_+|hypothetical-protein
MRALCIGALAVVSALALGGCSHPATPQFAVPCVDLSGQACADSPPVGEPTVLAPAEIAGQSSRKSAPAVARRAKLQRKHARAAKRRAASHATVTKPADKPSDKTRDKRTETSADKPINTPARTARPEPTSPPAAGESGAKPPPAVSDVLPNPAKVQSEVTVAAELAERMTALRVPEVPADTHLVAVLMARPNVRALADLSGKVIAIDERYAKSNAKITAAMNAAGASEVLLLEGQATAITRLTNGEVSAAVVALASPEAAEAFPKIAGFRLFSVMLTP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1291069 : 1326414

Catovirus(16.67%)

transposase,holin,integrase

attL 1294917:1294962|attR 1326587:1326632

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012041500.1\|1291069_1292674_-\|holin	choline dehydrogenase	A0A1V0S9J5	Catovirus	7.2e-51	29.6
WP_012041501.1\|1292853_1294287_-	coniferyl aldehyde dehydrogenase	NA	NA	NA	NA
1294917:1294962	attL	NA	NA	NA	NA
WP_012041502.1\|1295195_1298243_+	hypothetical protein	NA	NA	NA	NA
WP_041750364.1\|1298355_1299264_-	prolyl oligopeptidase family serine peptidase	NA	NA	NA	NA
WP_012041504.1\|1299278_1300175_-	hypothetical protein	NA	NA	NA	NA
WP_012041505.1\|1300260_1300488_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012041506.1\|1300518_1300842_-	DUF3768 domain-containing protein	NA	NA	NA	NA
WP_148221399.1\|1300951_1301443_-	hypothetical protein	NA	NA	NA	NA
WP_011931033.1\|1301485_1302088_-	plasmid pRiA4b ORF-3 family protein	NA	NA	NA	NA
WP_011931032.1\|1302084_1303647_-\|transposase	IS66-like element ISBrsp6 family transposase	NA	NA	NA	NA
WP_011931031.1\|1303698_1304052_-	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_011931030.1\|1304045_1304468_-\|transposase	transposase	NA	NA	NA	NA
WP_012041510.1\|1304509_1304692_-	hypothetical protein	NA	NA	NA	NA
WP_041751265.1\|1304904_1305291_-	hypothetical protein	NA	NA	NA	NA
WP_041751266.1\|1305965_1306541_-\|integrase	site-specific integrase	A0A1W6DWU1	Sphingobium_phage	2.3e-31	41.7
WP_148221400.1\|1307476_1308787_+	hypothetical protein	NA	NA	NA	NA
WP_012041517.1\|1308875_1309751_+	hypothetical protein	NA	NA	NA	NA
WP_168167872.1\|1309933_1310260_+	hypothetical protein	NA	NA	NA	NA
WP_148221383.1\|1310303_1311441_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.1e-32	34.8
WP_012041520.1\|1311617_1315013_-	DEAD/DEAH box helicase family protein	A0A0H5ARP5	Pseudomonas_phage	9.1e-11	25.5
WP_012041521.1\|1315009_1315867_-	transcriptional regulator	NA	NA	NA	NA
WP_041750367.1\|1316006_1317290_+	DUF2130 domain-containing protein	NA	NA	NA	NA
WP_012041523.1\|1317366_1319199_+	AAA family ATPase	NA	NA	NA	NA
WP_041750368.1\|1319195_1320530_+	ATP-binding domain-containing protein	NA	NA	NA	NA
WP_148221585.1\|1321009_1321303_+	hypothetical protein	NA	NA	NA	NA
WP_012041526.1\|1321437_1323687_-	phage / plasmid primase P4	Q9T0Y1	Lactobacillus_phage	2.7e-80	37.4
WP_012041527.1\|1323819_1324104_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012041528.1\|1324265_1325108_-	hypothetical protein	NA	NA	NA	NA
WP_012041529.1\|1325109_1326414_-\|integrase	tyrosine-type recombinase/integrase	A0A221SAN4	Ralstonia_phage	5.7e-38	32.8
1326587:1326632	attR	NA	NA	NA	NA

DBSCAN-SWA_2

3163550 : 3172555

uncultured_Mediterranean_phage(33.33%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012043169.1\|3163550_3165161_+	DUF853 family protein	A0A248XCZ8	Klebsiella_phage	9.1e-78	41.5
WP_012043170.1\|3165306_3166710_+	M20/M25/M40 family metallo-hydrolase	NA	NA	NA	NA
WP_012043171.1\|3166728_3167946_-	GGDEF domain-containing protein	G3MA91	Bacillus_virus	1.6e-18	36.0
WP_012043172.1\|3168095_3169193_-\|protease	trypsin-like serine protease	A0A1B1IT49	uncultured_Mediterranean_phage	2.3e-24	26.4
WP_012043173.1\|3169415_3169730_+	co-chaperone GroES	A0A221S4G8	uncultured_virus	1.2e-21	55.4
WP_012043174.1\|3169770_3171393_+	chaperonin GroEL	A0A240F779	uncultured_virus	1.3e-177	60.7
WP_012043175.1\|3171656_3171887_+	hypothetical protein	NA	NA	NA	NA
WP_012043176.1\|3172105_3172555_+	Hsp20 family protein	A0A1B1IW69	uncultured_Mediterranean_phage	2.9e-26	42.0

DBSCAN-SWA_3

4621964 : 4631618

uncultured_Mediterranean_phage(88.89%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012044445.1\|4621964_4623419_-	LysM peptidoglycan-binding domain-containing M23 family metallopeptidase	Q8SBN9	Clostridium_phage	7.3e-18	40.9
WP_041751544.1\|4623526_4624144_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	1.6e-27	48.1
WP_012044447.1\|4624451_4624847_+	response regulator	NA	NA	NA	NA
WP_012044448.1\|4624838_4625606_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	2.8e-37	38.3
WP_012044449.1\|4625701_4626061_-	hypothetical protein	NA	NA	NA	NA
WP_012044450.1\|4626164_4627493_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	4.5e-99	48.5
WP_012044451.1\|4627624_4628440_-	twin-arginine translocase subunit TatC	A0A1B1IVR7	uncultured_Mediterranean_phage	1.5e-52	46.4
WP_012044452.1\|4628436_4628979_-	twin-arginine translocase subunit TatB	A0A1B1IVT0	uncultured_Mediterranean_phage	5.9e-05	48.9
WP_006614346.1\|4629088_4629322_-	twin-arginine translocase TatA/TatE family subunit	A0A1B1IVR9	uncultured_Mediterranean_phage	4.2e-08	55.4
WP_012044453.1\|4629601_4630759_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	5.2e-43	49.7
WP_012044454.1\|4630778_4631618_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	3.1e-29	35.5

DBSCAN-SWA_4

5176345 : 5215041

Shigella_phage(25.0%)

integrase,transposase

attL 5176104:5176145|attR 5191946:5191987

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
5176104:5176145	attL	NA	NA	NA	NA
WP_012044936.1\|5176345_5177650_+\|integrase	site-specific integrase	A0A2H4JB45	uncultured_Caudovirales_phage	1.7e-13	30.6
WP_148221488.1\|5177646_5178123_+	hypothetical protein	NA	NA	NA	NA
WP_012044937.1\|5178307_5178556_+	hypothetical protein	NA	NA	NA	NA
WP_012044938.1\|5178742_5179051_+	hypothetical protein	NA	NA	NA	NA
WP_083780693.1\|5179212_5179389_+	hypothetical protein	NA	NA	NA	NA
WP_012044939.1\|5180071_5182282_+	hypothetical protein	A0A1W6JQ82	Corynebacterium_phage	7.9e-40	41.8
WP_012044940.1\|5183068_5183713_+	recombinase family protein	A0A0F7L6S1	uncultured_marine_virus	5.2e-24	38.5
WP_012044941.1\|5183871_5184723_+	HNH endonuclease	NA	NA	NA	NA
WP_012044942.1\|5184757_5185657_+	ATP-binding protein	NA	NA	NA	NA
WP_012044943.1\|5185789_5186200_+	hypothetical protein	NA	NA	NA	NA
WP_012044944.1\|5186199_5187648_+	hypothetical protein	NA	NA	NA	NA
WP_168167913.1\|5187667_5187823_+	hypothetical protein	NA	NA	NA	NA
WP_012044945.1\|5187819_5188113_+	hypothetical protein	NA	NA	NA	NA
WP_148221489.1\|5188159_5188933_+	hypothetical protein	NA	NA	NA	NA
WP_041750836.1\|5188916_5189138_+	hypothetical protein	NA	NA	NA	NA
WP_148221490.1\|5189236_5191456_-	DUF2254 domain-containing protein	NA	NA	NA	NA
WP_041751575.1\|5193511_5193718_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
5191946:5191987	attR	NA	NA	NA	NA
WP_012044951.1\|5194267_5194981_-	hypothetical protein	A0A291AUS5	Sinorhizobium_phage	5.0e-12	43.3
WP_012044953.1\|5195404_5195650_-	hypothetical protein	NA	NA	NA	NA
WP_041751576.1\|5195646_5196114_-	hypothetical protein	NA	NA	NA	NA
WP_012044955.1\|5196353_5197262_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_012044956.1\|5197671_5198568_+\|transposase	transposase	NA	NA	NA	NA
WP_041750838.1\|5198856_5199207_+	hypothetical protein	NA	NA	NA	NA
WP_012044958.1\|5199299_5202710_-	AAA family ATPase	NA	NA	NA	NA
WP_012044959.1\|5202706_5204530_-	hypothetical protein	NA	NA	NA	NA
WP_012044960.1\|5204534_5205683_-	trypsin-like peptidase domain-containing protein	NA	NA	NA	NA
WP_012044961.1\|5205960_5207334_+	hypothetical protein	NA	NA	NA	NA
WP_049795396.1\|5208261_5208543_-	hypothetical protein	NA	NA	NA	NA
WP_049795508.1\|5209043_5209394_-\|transposase	transposase	NA	NA	NA	NA
WP_148221492.1\|5209479_5210649_-	GRRM system radical SAM/SPASM domain protein	NA	NA	NA	NA
WP_012044965.1\|5210629_5210929_-	hypothetical protein	NA	NA	NA	NA
WP_168167914.1\|5211654_5212461_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	1.6e-30	35.3
WP_083780697.1\|5212580_5212976_+\|transposase	transposase	Q76S41	Shigella_phage	5.4e-08	46.4
WP_041750840.1\|5212972_5213320_+	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZDM8	Stx2-converting_phage	5.2e-31	56.6
WP_012044968.1\|5213391_5215041_+\|transposase	IS66 family transposase	A0A0P0ZEB3	Stx2-converting_phage	2.1e-106	42.5

DBSCAN-SWA_5

5873581 : 5879838

Yellowstone_lake_phycodnavirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012045550.1\|5873581_5874304_+	nucleotidyltransferase family protein	A0A127AW70	Bacillus_phage	3.8e-07	23.1
WP_012045551.1\|5874412_5875351_+	SDR family oxidoreductase	E3T4Y8	Cafeteria_roenbergensis_virus	3.7e-07	28.8
WP_012045552.1\|5875347_5875956_+	SIS domain-containing protein	NA	NA	NA	NA
WP_012045553.1\|5875968_5876967_+	NAD-dependent epimerase/dehydratase family protein	A0A0N7KVW3	Yellowstone_lake_phycodnavirus	1.6e-35	35.8
WP_012045554.1\|5877023_5877872_+	transketolase	A0A0P0YMZ3	Yellowstone_lake_phycodnavirus	7.8e-12	36.1
WP_012045555.1\|5877868_5878792_+	transketolase	A0A0P0YNE1	Yellowstone_lake_phycodnavirus	2.0e-16	31.0
WP_012045556.1\|5878800_5879838_+	zinc-binding dehydrogenase	E3SJ82	Synechococcus_phage	4.1e-55	37.4

DBSCAN-SWA_6

6862117 : 6879996

Rhizobium_phage(33.33%)

tail,plate,portal,terminase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012046426.1\|6862117_6863236_-\|plate	baseplate J/gp47 family protein	M1PJA4	Vibrio_phage	1.5e-10	27.4
WP_012046427.1\|6863235_6863793_-	phage protein	A0A068CDD6	Rhizobium_phage	1.6e-18	36.5
WP_012046428.1\|6863794_6864313_-	bacteriophage protein, gp45-like protein	NA	NA	NA	NA
WP_012046429.1\|6864315_6865419_-\|tail	phage tail protein	A0A068CH59	Rhizobium_phage	9.7e-39	32.1
WP_012046430.1\|6865422_6866691_-	DNA circularization protein	NA	NA	NA	NA
WP_012046431.1\|6866834_6868841_-	hypothetical protein	A0A1S5NRM8	Burkholderia_phage	2.4e-19	25.9
WP_012046432.1\|6869056_6869356_-	hypothetical protein	NA	NA	NA	NA
WP_012046433.1\|6869424_6869814_-	hypothetical protein	NA	NA	NA	NA
WP_012046434.1\|6869889_6871389_-\|tail	Mu-like prophage FluMu tail sheath protein	A0A068CC80	Rhizobium_phage	4.7e-68	35.5
WP_012046435.1\|6871468_6871798_-	DUF2635 domain-containing protein	NA	NA	NA	NA
WP_148221533.1\|6871798_6872320_-	hypothetical protein	NA	NA	NA	NA
WP_148221534.1\|6872568_6872910_-	hypothetical protein	NA	NA	NA	NA
WP_012046438.1\|6872981_6873326_-	DUF2190 family protein	NA	NA	NA	NA
WP_012046439.1\|6873416_6875471_-\|protease	Clp protease ClpP	A0A1W6JT88	Pseudomonas_phage	3.1e-107	41.7
WP_012046440.1\|6875442_6876981_-\|portal	phage portal protein	D4HTU3	Vibrio_phage	4.5e-58	32.2
WP_012046441.1\|6876980_6877241_-	hypothetical protein	NA	NA	NA	NA
WP_012046442.1\|6877271_6877925_-	hypothetical protein	A0A1X9SH03	Bradyrhizobium_phage	2.4e-37	41.7
WP_012046443.1\|6877962_6879996_-\|terminase	terminase	A0A0A8ILA6	Aurantimonas_phage	5.6e-157	47.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_009475

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_009485

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection