CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_008697	Nocardioides sp. JS614 plasmid pNOCA01, complete sequence	0 crisprs	csa3,PD-DExK	0	0	0	0
NC_008699	Nocardioides sp. JS614, complete sequence	34 crisprs	cas3,csa3,DEDDh,cas4,WYL,c2c9_V-U4,DinG	22	1	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_008699_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_1

156226-156310

Orphan

Consensus_repeat	Method
TCCCCGGTGAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_1

>merge|NC_008699|1|156226-156310|CRISPRCasFinder
TCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAACATCCCCGGTGAACCGGGGAAACCG

>NC_008699|1|1|156226-156310|CRISPRCasFinder
TCCCCGGTGAACCGGGGAAACCG	GAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAACA
TCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011753642.1\|160033_161599_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238119
NC_008699.1\|WP_172419803.1\|143604_145524_+\|peptidase-M13	unknown	unknown	gnl\|CDD\|226118
NC_008699.1\|WP_011753639.1\|156986_157367_-\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NC_008699.1\|WP_011753628.1\|145777_146350_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753641.1\|159673_159841_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753637.1\|156320_156584_-\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197385
NC_008699.1\|WP_011753636.1\|155619_156168_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_008699.1\|WP_011753646.1\|166368_167466_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_140403767.1\|146444_148619_+\|ATP-dependent-DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|223588
NC_008699.1\|WP_011753643.1\|161747_163259_+\|acetyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|178415
NC_008699.1\|WP_041547004.1\|150059_151478_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NC_008699.1\|WP_011753644.1\|163347_165252_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|227111
NC_008699.1\|WP_011753630.1\|148880_149261_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753633.1\|151664_152153_-\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|223463
NC_008699.1\|WP_011753645.1\|165251_166199_+\|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|163676
NC_008699.1\|WP_011753638.1\|156585_156990_-\|DUF302-domain-containing-protein	unknown	unknown	gnl\|CDD\|269820
NC_008699.1\|WP_011753631.1\|149284_149956_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753635.1\|154924_155605_+\|SWIM-zinc-finger-family-protein	unknown	unknown	gnl\|CDD\|226729
NC_008699.1\|WP_011753640.1\|157492_159649_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_008699.1\|WP_011753634.1\|152213_154925_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223627

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011753642.1\|160033_161599_+\|VWA-domain-containing-protein	gnl\|CDD\|238119	cd00198, vWFA, Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.	3.38363e-08
NC_008699.1\|WP_172419803.1\|143604_145524_+\|peptidase-M13	gnl\|CDD\|226118	COG3590, PepO, Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones].	0
NC_008699.1\|WP_011753638.1\|156585_156990_-\|DUF302-domain-containing-protein	gnl\|CDD\|269820	cd14797, DUF302, Uncharacterized domain family DUF302. These domains are mostly found in bacterial single-domain proteins and have been shown to form homodimers; they may also bind zinc. Also characterized as COG3439.	4.22616e-39
NC_008699.1\|WP_011753637.1\|156320_156584_-\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|197385	cd10148, CsoR-like_DUF156, Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156. This superfamily includes various transcriptional regulators that respond to stressors including Cu(I), Ni(I), sulfite, and formaldehyde. It includes CsoR (copper-sensitive operon repressor) from Mycobacterium tuberculosis (MtCsoR), Bacillus subtilis (BsCsoR), Thermus thermophilus (TthCsoR), and Staphylococcus aureus (SaCsoR), Mycobacterium tuberculosis RicR (regulated in copper repressor, MtRicR), Escherichia coli RncR (formally known as YohL, nickel and cobalt-sensitive), Alcaligenes xylosoxidans NreA (nickel-sensitive), E. coli FrmR (formally known as YaiN, formaldehyde sensitive), and Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor, NWMN_0026.5, SaCstR). CsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis. For example, TthCsoR binds the promoter region of the copZ-csoR-copA operon, and represses expression of these genes, which encode the copper chaperone CopZ, CsoR, and the copper efflux P-type ATPase CopA, respectively. In the presence of excess Cu(I), TthCsoR binds this ion, and is released from the DNA, allowing expression of the downstream genes. TthCsoR also senses other metal ions such as Cu(II), Zn(II), Ag(I), Cd(II) and Ni(II). CsoRs form a homotetramer (dimer of dimers). In the case of MtCsoR, two Cys residues on opposite subunits within each dimer, along with a His residue, bind the Cu(I) ion. These residues are conserved in the majority of members of this superfamily. Exceptions include the functionally uncharacterized Bacillus subtilis YrkD where there is an Asn instead of His (C-N-C), E.coli RcnR where there is a Thr instead of the second Cys (C-H-T), or TthCsoR and E.coli FrmR where there is a His instead of the second Cys and which have an additional N-terminal His (not found in those family members having C-H-C) that may also be involved in metal binding (H-C-H-H). A conserved Tyr and a Glu residue facilitate allosteric regulation of DNA binding. SaCstR regulates genes predicted to function in sulfur metabolism; it is thought that oxidation of the intersubunit Cys pair to a mixture of disulphide and trisulphide linkages by sulfite, results in a reduced affinity of SaCstR for the operator DNA. SaCstR exists as a mixture of oligomeric states, including dimers, tetramers and octamers. The sequence of SaCstR was not available at the time this hierarchy was curated and therefore was not included. Escherichia coli RncR represses expression of the gene encoding the nickel and cobalt-efflux protein RcnA. The gene encoding Alcaligenes xylosoxidans NreA is part of the nre nickel resistance locus located on the pTOM9 plasmid from thisbacteria. Escherichia coli FrmR regulates the formaldehyde degradation frmRAB operon.	4.62482e-24
NC_008699.1\|WP_011753636.1\|155619_156168_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	6.94345e-13
NC_008699.1\|WP_140403767.1\|146444_148619_+\|ATP-dependent-DNA-helicase-RecQ	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	1.3273e-120
NC_008699.1\|WP_011753643.1\|161747_163259_+\|acetyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|178415	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain.	0
NC_008699.1\|WP_041547004.1\|150059_151478_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.04827e-120
NC_008699.1\|WP_011753644.1\|163347_165252_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NC_008699.1\|WP_011753633.1\|151664_152153_-\|glutathione-peroxidase	gnl\|CDD\|223463	COG0386, BtuE, Glutathione peroxidase [Posttranslational modification, protein turnover, chaperones].	3.7208e-76
NC_008699.1\|WP_011753645.1\|165251_166199_+\|hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|163676	cd07938, DRE_TIM_HMGL, 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain. 3-hydroxy-3-methylglutaryl-CoA lyase (HMGL) catalyzes the cleavage of HMG-CoA to acetyl-CoA and acetoacetate, one of the terminal steps in ketone body generation and leucine degradation, and is a key enzyme in the pathway that supplies metabolic fuel to extrahepatic tissues. Mutations in HMGL cause a human autosomal recessive disorder called primary metabolic aciduria that affects ketogenesis and leucine catabolism and can be fatal due to an inability to tolerate hypoglycemia. HMGL has a TIM barrel domain with a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. The cleavage of HMG-CoA requires the presence of a divalent cation like Mg2+ or Mn2+, and the reaction is thought to involve general acid/base catalysis. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	7.85599e-152
NC_008699.1\|WP_011753639.1\|156986_157367_-\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	7.42418e-39
NC_008699.1\|WP_011753635.1\|154924_155605_+\|SWIM-zinc-finger-family-protein	gnl\|CDD\|226729	COG4279, COG4279, Uncharacterized conserved protein [Function unknown].	7.5259e-26
NC_008699.1\|WP_011753640.1\|157492_159649_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	4.65784e-74
NC_008699.1\|WP_011753634.1\|152213_154925_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223627	COG0553, HepA, Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair].	7.42313e-111

>NC_008699.1|WP_011753636.1|155619_156168_-|TetR/AcrR-family-transcriptional-regulator
MSRRDQILATAAELFAAHGYHGVSVADLGAACGISGPALYKHFASKQAVLAEMLVAISEELLRVGTERVAAATGPRTAIAALVDWHVDFALRHRALIVVQDRDWEALPEEARERVRTLQREYVDLWAAQLRLADPRLDLATARAMAHAAFGLINSTPHSGLLPDTDMRGLLSRMALGALGAG
>NC_008699.1|WP_011753635.1|154924_155605_+|SWIM-zinc-finger-family-protein
MTGTVLHPRVAPRRATARATTWWGKAWVRAVDEAAYAEADLVASRALARAGRVGQIATEPGRFVAAVEDRRGLWTVEGTVPVLGAADVAALVETVAAESGRIAALLAGELPHRLVEHAEEAGVELLPYGGELGASCTCEHWVDPCVHALAVLHQLAWLVDADPFVLLQLRGLARDELLGRLHERSAAPLVEPRDSADGTVDEDEPDLQAALEAALYAARLLVDPLS
>NC_008699.1|WP_011753634.1|152213_154925_+|DEAD/DEAH-box-helicase
MSFVPVTGPATFRAADPPREGVVEFTDDRRTVSLPIRAALPVLTKARSRDDLHPSVGVLSGAALLALRLVAAGKFAPAGSSPPAWRVAGLDADDEQRIVLLARNGPDDEQLVRDLLDAVADAMPRTQPRTQPRSRPSAEPSGTTVSRERRPTFEERLQARLARHQRVDARALPQLVTISLRVEADEEELVAGAVRLVAQAHDEQNPLHLCDLALLWTGTPQEHGFGERARTHATIALRAAADAWPVLDRLLELRVPDQLTLDSDELVSLLDEGVGALRAAGVDVLWPKALGRDLTATTVLDRAAPMTREEPLNEPVLGAEALFAFNWQIALHGDPLTAEEMDRLATSASPLLRLRGSWTVVDPSIARKAKKRLVRTVKPAEAVAAALTGTAQIAAPGGEQSEQDVVVGASLLKVRDRLLGAATREPVEPPAALRATLRDYQRHGLTWLAEMTSLGLGACLADDMGLGKTVTLIALHLHRAERGHRGPTLVVCPASLLGNWEAEVRRFAPGVPVVRFHGTSRDVEAAGDGFVLTTYGTMRRDAEALGSVRWDLVVADEAQHVKNPRTATARALRSITSAARVALTGTPVENDLTELWAILDWTTPGLLGSRNAFRKAWAAPIESGREPAKARQFADLIGPFLLRRRKSDPGIAPELPAKTETDHPLRLTREQVVLYESFVRDTMARIERADPSDPVARRGLVLTLLTGLKQICNHPDHFLKRSGARLSGRSEKVDLLDELVGTVLAEDGAVLVFTQYVAMARLLEGHLARAGVPHQLLHGGTPVREREAMVARFQAGETPVFLLSLKAGGTGLNLTRADHVVHVDRWWNPAVEEQATDRAYRIGQTKPVQVHRMITRGTVEEKVAELLTRKRALADAVLSRGEAALTELSDDELRDFVALRRDP
>NC_008699.1|WP_011753633.1|151664_152153_-|glutathione-peroxidase
MSILDAKIARLDGTPSTLGEITGGRPALLVNVASKCGLTPQYAGLEELHERLADRGFTVVGLPCNQFRGQEPGTADEIAEFCSATYGVTFPMTEKIDVNGPDRHEIYRTLVDTPNESGESGDITWNFEKFLVDASGAVLARFSPGVEPGDPRLVAAVESQVG
>NC_008699.1|WP_041547004.1|150059_151478_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MVAGVVVLGAIMSILDITVVSVALQTFQQEFDATSAEVAWTMTGYTLALASVIPLTGWAADRFGTKRLYLLAVLLFTAGSVLCAAATSLEMLVSFRVLQGVGGGMLMPLGMTILTRAAGPERVGRVMAVLGIPMLLGPIFGPILGGALIDSASWHWIFLINLPIGIAALAYAAVVLPRDHVEPSETFDWLGMVLLSPGLAAFLYGVSSIPAAREEHGTLWTTEVVAPALAGLLLIAAFVPWALNRRNLHPLVDLRLFGNGTMTAAVLSMSLFAIAFFGASLLFPLYFQWVRGEDALGAGLLLAPQGVGAMITMPIAGVLADRIGPGKIVLTGIAVITVGMGMFTQLDQDTSYAYLLTALFVMGLGMGATMMPIMSAALATLREHTIARGSTLMNIVQQVAASIGTAVFAMLLTNGTIDLDPSDPAGFVTGLADAFAHVFVVATVMVALVLVPAFFLPRRKVAPADPTLVVGH
>NC_008699.1|WP_011753631.1|149284_149956_+|hypothetical-protein
MTSQDDSPDDGRRAAELGERLAAWLEELGLGAHLAAAGLPTCERDEHGRAAWTDPNTGLPMTGEQLEDLERLLRSEGADPQHAVPVQLVQIARRARVRQELLDSAWYDYESLAELRGTSVDATRFAVHKAEGEHRLLVVAADARTLVPAFQLTPEGNLRPELGPVLTSLLAARMDPWQAWAWLTQPAGLLGGEVPERAAADPETADVVQRAAARLAERAGARP
>NC_008699.1|WP_011753630.1|148880_149261_+|hypothetical-protein
MAEGATNRVAADKEYLDEYGFRGRLQQRVDGLTYAVAGLLTAAPEPQELLESVRAAADRGTRFLLVAAGDVETEGLAAQRLLTAAPDLVEVWTVPGAGHVQGLRTDPEGWSQRVVGFLDAALVGPR
>NC_008699.1|WP_140403767.1|146444_148619_+|ATP-dependent-DNA-helicase-RecQ
MSGPAGRQGRVSAPAETDVRRSAEAHLRALVGPRPGEPEPVLREDQWAAIEALAVHRRRALVVQRTGWGKSAVYFVATLLLREQGAGPTVIVSPLLALMRNQIAAAERAGIRAVTINSTNIEDWEPIHEAIAAGEVDVLLVSPERLNNPGFRDEVLPRLAATCGLLVVDEAHCISDWGHDFRPDYRRIRTLLGELPDGIPVLATTATANARVTDDVAEQLGVSTGSATDGFGEVLVLRGSLDRESLRLGVVRLRTAEQRLAWLADHLAEQPGSGIVYCLTVAATQEIADYLRSRGHEVAAYSGQTDPTERHALEQDLVNGRVKALVATSALGMGFDATLGFVVNMGAPPSPVAYYQQVGRAGRGTTLPPEGATVVLLPAIEDRDIWAYFASLAFPREEQVRRTLEVLGAEGRPLSTATLETYVDLNRTRLETMLKVLDVDGAVRRVRGGWEATGREWSYDEERYRRVTEARQREQQAMLDYIATDACRMRFLRDQLDDPEAEDCGRCDNCGGLTLSADVSAAALEDAGARLARPGVAVEPRKMWPSALANLGIELKGKIAEGAQEGRAVARLTDLGHGQALRELFAPATPDGPVPVPLVRAVLEVLGDWRPPVDAIVVVESQTRPTLTADLAAGLSRHLGVPVVGRWAIVNPDIVPGQGAANSAQRVAAVGRRFALQVDQPLDGLRVLLVDDRTDTGWTLTLAARAVRRAGAAEVRPLVLATTT
>NC_008699.1|WP_011753628.1|145777_146350_-|hypothetical-protein
MSNHRTLAFAAVASLATLGLVGGATTTSSADADGFAPHVGQRVAAKATAPVKCGGGALKKMTSRLSAEPFSFAGTAGADVAVTGAQVALTGPPKGTDTVLVTFTAESYYTGSGWMSLELHKDGVPAAPYADNGSPFAFTSEASYHGDSAQFCTKIGTGTHVLAIQASTTGNSSTDSGWIDDWTMSVPRFE
>NC_008699.1|WP_172419803.1|143604_145524_+|peptidase-M13
MSPEIRPQDDLFGHVNGRWLDETEIPADRSSWGPFIQLADTAETQVHEIIEDLARRVAAGEPVDEDAHKIGDLFASFMDTETIARNGLRPVRPLIEAVAGLRDVRDLAAFLGEFERIGGHGLFGSYVDTDSKNSDRYLFNLVQGGLGLPDESYYRDEKFAEIREKYVAYLTTLFGLGEHPDPAAAAATVLAIDTRMAAGHWERAETRDVQKTYNLMTRAELIELSPGFDWDAYVTNLGGNEETLAEVCVRQPSYFTHLSVLLDEISLEDWREWLLAHVLRSAAAYLTDDFVETNFDFYGRTLSGTPELRARWKRGVALVEGAIGEAVGKEYVARHFPPRSKAMMDELVANLLAAYRQSISRLDWMTEETKQRAYDKLDRFRPKIGYPEKFRDYSALRVTRDDLLGNVAAASAFETDRQLAKIGSPVDRDEWFMLPQTVNAYYNPGTNEICFPAGILQKPFFSPDAEEAENYGGIGAVIGHEIGHGFDDQGAQYDGSGNLHDWWTPDDKAAFEVKSKALIEQYDGFEPRTLPGERVNGALTVGENIGDLGGLTIGHTAYLIARGGSASVEDRQKVFLNWAYCWRTKRRKEQEQQYLTIDPHSPAEFRANIVRNLDEFHEVFGTVEGDGLWLDPDQRVRIW
>NC_008699.1|WP_011753637.1|156320_156584_-|metal-sensitive-transcriptional-regulator
MELDPQEMTPVINRIKRAQGQLAGVLRMLEEGRECEDVVTQLAAVSRALDRAGFAIVATGLQQCLTTGDGLDSLDAKKMEKLFLSLA
>NC_008699.1|WP_011753638.1|156585_156990_-|DUF302-domain-containing-protein
MSFTLSATVERPYDETVAEVREALAGQGFGVLTEIDIRATLAAKLGVDVPPQVILGACRPQLAHRALEIDPTIAAVLPCNVVVRSLGEHTTVVEAFDPDAMMGLAGDGLTEVAGEARQRLSAALAALTPPAEES
>NC_008699.1|WP_011753639.1|156986_157367_-|thioredoxin
MTTTTLTAAQFEETVTGNDIVLVDFWASWCGPCRQFAPVFEAASEKHPDVVFGKVDTEAERELAAAAQITSIPTLMAFREGVLVFAQPGALPATSLEQVIGAVRELDMDDVRAQLAAQSQDQEENQ
>NC_008699.1|WP_011753640.1|157492_159649_+|MMPL-family-transporter
MSTITTPPDVDPEIGYRPGPLGRLGVWVTHHTRATAVVWLLVIVGLGAFAPKVEAELSGAGWQADGSESVAARELAQEHFGGNASSAIQVVVHSSKIPLDSSSGQRILDRATALLEEDPRIAEVVQPQPGATLSEDGRTAVLLAGAAADPNEMVRAADDLKGPLQDLSTAGIQVNPTGASLLWSDFNEANLDAMLKSEMFSWPVTLAILVLAFGALVAAGLPLILTLAGLVASAGSLVLINQVVPVSIWAMNFAMMFALALGIDYALFLVVRFRAARMGHHESPRQAIAETMDTAGKAVLLSGATVLISLSAVMLVPSPSFRSMAGGIMLSVVFVLAATLTLLPLVLHLLDQRINKLALPWVHTGEHRSPKFAAWGERLWKRPIVFGLAALFILLALAAPILGLKTAMPSIKVLPEDASARVGYDLVQESFGEGAPGTLQVVTTGADAEATYDALGADPGIAAAMPPMPAPDGTDHVLIQAVPTVDPSDPGLGATVDRLRADLPESAIVGGAAVENLDLKSQLDDSTPLVIGVILALGFLLLLVALQAPLIALLGTLASLLSTAAAFGVARLIFQEGWGSGLLGFESQGFLDAWAPVFFFAMIFAIAMDYTVFLLASAKEHFEHTGDPKDAMVGSLAHSGRVIFAAGAVMVAVFFTFALSGPLPPKEMGVVLGVAVLLDAFLVRLVLLPVLLRLTGRAAWYVPRWLDRVLPDVRFSHS
>NC_008699.1|WP_011753641.1|159673_159841_+|hypothetical-protein
MCHRTTCRRCGKASWAGCGAHVSQVMAGVPKADRCPGHEGEPPLPGFLSRLLGRA
>NC_008699.1|WP_011753642.1|160033_161599_+|VWA-domain-containing-protein
MQFTTSRAIVRRLVPAAAGAAVLATVASSAALAAPGVTPAHYTDALDPGSTVTITKTVETPPIPPRPDIVFLADTTGSMGGSIANVRSNANAILAQIQAAQPTARFAVAEYKDESDGPAAVFHVDQQLTDSTADVVAGINAWSASGGGDAPEAWIGALGRIPSSIDFRPDGTRVLVMFGDAPSHDPSLGFTLGSATSGLQASGVRVIAIDVPGTAGGLDALGQATHVTSQTGGSLAAADPDQVASTILSELQNLPAVVTHDTTCDPGASLSFDQASRTVTSGDSTTFDETITVAGDAVQGSVLTCTTRFLVNGELPGPEFVQTVEIAVNDVTPPVVTVESKTVEATGPDGATVGYTSSATDNVDGPLTPTCTPASGSLFGLGATTVTCAATDAAGNTGTGTGTITVVDTTPPSVGCPEAENPGGQVPGAHNEDGFFRLEASDIVDGDVDVYLRDTGSGTVFGPYASGQRVKYTENGAKPSVKTMPSGILHITGTGDAEVYAVDFSGNTSAPAACLVPQPPK
>NC_008699.1|WP_011753643.1|161747_163259_+|acetyl-CoA-carboxylase-subunit-beta
MKELVDELRERLATARQGGSEKARRKHTDRGKLLVRDRVDRLLDPGSPFLELSPLAADGMYGGAVPSAGVVTGIGRVSGREVVVVANDATVKGGTYYPMTVKKHLRAQTVAADNRLPCVYLVDSGGAFLPMQDEVFPDREHFGRIFFNQANLSARGIPQIASVMGSCTAGGAYVPAMSDETVIVRNQGTIFLGGPPLVKAATGEVVTAEELGGGDVHARTSGVADHLAEDDAHALAIVRSIVETVGPRAAAPWEVHPVEEPHEDPTSLYDVIPADTRTPYDVREVIRRVVDGSRFHEFKKLYGETLVTGFARVWGHPVGIVANNGILFSESSLKGAHFIELCNQRGIPLVFLQNITGFMVGKEYENGGIAKDGAKLVTAVACSVVPKFTVVIGGSFGAGNYGMCGRAYDPRFLWMWPNARISVMGGEQAASVLATVAGRPDDEEFKAPIREQYETQGSPYYSTARLWDDGIIDPADTRRVLGMGLAAAANAPVPAPTYGIFRM
>NC_008699.1|WP_011753644.1|163347_165252_+|ATP-grasp-domain-containing-protein
MTNSLAAVLESVLVANRGEIALRVMRACRKYGVRTIAIYTDLDVDAPHVRAADDAVHVSSYLDIDAVVAAAVASGATAVHPGYGFLSERSAFVRAVEAAGVVFVGPPADVMDKMGRKDAAREIAVAAGVPVVPRGEDAGFPVLVKAAAGGGGKGMRVVREEADLEEAKAAAAREALAAFGDDTLLIEKYVERGRHIEVQIMADAHGHVVHLDERDCSTQRRHQKVLEEAPAPTISPEVRELVTSSAVALAKQVGYVNAGTVEFLVDDDTGEAYFLEMNTRLQVEHPVTELIHHDLDLVLHQLLVALGHPLEIEQDNVRPSGHAIEARVYAEDSFGGFLPQAGRTSIVRWPAGVRVDHALEPDQVVSTSYDPMLGKVIVHGPDRESARRALVDALDRTAILGLTTNVGFLRALVASEEFRDAAIDTAWLDRNSVPAPDDDLPRVFVAWVSAMLAAGHDSGQPFRADGWRSGADPAPTIVELDRPVVVDRFAGLVDGRAVRQVAAADHVLTLEVDGRVHSAVVNVQPHVAEVVHHGQRFVFERPDVFGDHAVDVGDGAIAAPMPGTVLDVRVEPGATVVAGDVLGVLEAMKMELTLKAPFDGTVSQVGATIGAQVALGARLFVVEPHAEAEEEEAG
>NC_008699.1|WP_011753645.1|165251_166199_+|hydroxymethylglutaryl-CoA-lyase
MRTPAVVPALPVSAAPMPDRVTIYEVGPRDGLQNEKSLVPTDVKAEFVRRLLAAGLPIVEATSFVHPKWVPQLADAAELMALLGPAGRDCPVLVPNERGLDRALELGVRHVAIFGSATETFAQKNLNRSLDEQFAMFEPTVRRARDAGLDVRAYVSMCFGDPWEGAVPIEQVVGVGKRLFDLGASQLSIGDTIGVGTAGHVTALVRAFDEVGLGTDRLALHFHDTFGQALANTYAALQAGITTFDASAGGLGGCPYAKSATGNLATEDLVWMLRGLGIETGVDLEEVAATSVWMAAHLGRPSPSAVVRALAPSAS
>NC_008699.1|WP_011753646.1|166368_167466_+|hypothetical-protein
MSRKVYLHIGAPKTGTTYLQDRLTVNAKTLAAQGVHFPTGSPLVSPGLYQFRAALDLLGQDWGGPPGHADGSWEGLVRRARRRSGTVVISHEILAPAAPGQVARAMRDLAGSEIHVVYTARDLARQLPAAWQESIKQGRRWSYRRFLDRFEKGRSWFYRAFDVPRVLGTWGAGLPPERVHVVTVPHARVQTQHGDQLWLRMCEVLGIDPVWAPLDSDRSNRSLGIAETQVIRQLNRRMDRAARRESTYDALIRDMLAQGELVKRESAAVRLPPERFAWVEERAERWIEWIEGSGVHVVGDVAELRPVRPAEDERWRDPDRVRAKRQLATALDALAAMTREAARRPDPERQLTTRVLAQAQRLRDR

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Crispr_ID: NC_008699_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_2

183660-183748

Orphan

Consensus_repeat	Method
TCCCCGGTTAACCGGGGAAACCGGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_2

>merge|NC_008699|2|183660-183748|CRISPRCasFinder
TCCCCGGTTAACCGGGGAAACCGGAACTTATCGGCCGAAACTTCGGGCCAACAGTTCCAACATCCCCGGTTAACCGGGGAAACCGGAAC

>NC_008699|2|2|183660-183748|CRISPRCasFinder
TCCCCGGTTAACCGGGGAAACCGGAAC	TTATCGGCCGAAACTTCGGGCCAACAGTTCCAACA
TCCCCGGTTAACCGGGGAAACCGGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011753671.1\|188776_189625_+\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223635
NC_008699.1\|WP_041546058.1\|190955_191534_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239632
NC_008699.1\|WP_011753661.1\|179429_179804_-\|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|237999
NC_008699.1\|WP_172419801.1\|178260_179397_-\|adenylate/guanylate-cyclase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NC_008699.1\|WP_011753665.1\|182922_183609_-\|nickel-pincer-cofactor-biosynthesis-protein-LarB	unknown	unknown	gnl\|CDD\|224605
NC_008699.1\|WP_011753672.1\|189624_190122_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NC_008699.1\|WP_140403777.1\|184809_185208_+\|DUF4446-family-protein	unknown	unknown	gnl\|CDD\|379655
NC_008699.1\|WP_011753659.1\|177385_178240_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223267
NC_008699.1\|WP_011753668.1\|185228_185696_+\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|211538
NC_008699.1\|WP_011753662.1\|179898_181122_-\|arginine-deiminase	unknown	unknown	gnl\|CDD\|234949
NC_008699.1\|WP_041546055.1\|183810_184683_-\|prephenate-dehydratase	unknown	unknown	gnl\|CDD\|237014
NC_008699.1\|WP_011753656.1\|175147_175516_+\|methylmalonyl-CoA-epimerase	unknown	unknown	gnl\|CDD\|319911
NC_008699.1\|WP_011753657.1\|175512_176310_+\|glycerophosphoryl-diester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176524
NC_008699.1\|WP_011753675.1\|191630_192209_-\|bacterial-proteasome-activator-family-protein	unknown	unknown	gnl\|CDD\|378489
NC_008699.1\|WP_011753658.1\|176320_177259_+\|SEC-C-domain-containing-protein	unknown	unknown	gnl\|CDD\|235521
NC_008699.1\|WP_011753663.1\|181154_181745_-\|TMEM165/GDT1-family-protein	unknown	unknown	gnl\|CDD\|225030
NC_008699.1\|WP_011753670.1\|187505_188780_+\|serine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235461
NC_008699.1\|WP_011753673.1\|190118_190913_+\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|319818
NC_008699.1\|WP_041546056.1\|185795_187370_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|224513
NC_008699.1\|WP_011753664.1\|181744_182926_-\|nickel-pincer-cofactor-biosynthesis-protein-LarC	unknown	unknown	gnl\|CDD\|235249

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011753671.1\|188776_189625_+\|HAD-family-phosphatase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.21204e-55
NC_008699.1\|WP_041546058.1\|190955_191534_+\|hypothetical-protein	gnl\|CDD\|239632	cd03577, NTR_TIMP_like, NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by non-covalently binding their active zinc-binding sites. This group contains domains similar to the TIMP NTR domain, which binds MMPs. Members of this group may or may not function as MMP inhibitors.	9.09752e-30
NC_008699.1\|WP_011753661.1\|179429_179804_-\|cyclic-nucleotide-binding-domain-containing-protein	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	1.81612e-16
NC_008699.1\|WP_172419801.1\|178260_179397_-\|adenylate/guanylate-cyclase-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	3.02312e-32
NC_008699.1\|WP_011753665.1\|182922_183609_-\|nickel-pincer-cofactor-biosynthesis-protein-LarB	gnl\|CDD\|224605	COG1691, COG1691, NCAIR mutase (PurE)-related proteins [General function prediction only].	5.87389e-73
NC_008699.1\|WP_011753672.1\|189624_190122_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	5.13696e-16
NC_008699.1\|WP_140403777.1\|184809_185208_+\|DUF4446-family-protein	gnl\|CDD\|379655	pfam14584, DUF4446, Protein of unknown function (DUF4446). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 165 and 176 amino acids in length.	1.81584e-39
NC_008699.1\|WP_011753659.1\|177385_178240_-\|hypothetical-protein	gnl\|CDD\|223267	COG0189, RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis].	9.77882e-11
NC_008699.1\|WP_011753668.1\|185228_185696_+\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|211538	TIGR00026, Hypothetical_protein_Rv1261c/MT1299/Mb1292c., deazaflavin-dependent oxidoreductase, nitroreductase family. This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity].	2.30289e-27
NC_008699.1\|WP_011753662.1\|179898_181122_-\|arginine-deiminase	gnl\|CDD\|234949	PRK01388, PRK01388, arginine deiminase; Provisional.	0
NC_008699.1\|WP_041546055.1\|183810_184683_-\|prephenate-dehydratase	gnl\|CDD\|237014	PRK11899, PRK11899, prephenate dehydratase; Provisional.	0
NC_008699.1\|WP_011753656.1\|175147_175516_+\|methylmalonyl-CoA-epimerase	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	4.99256e-12
NC_008699.1\|WP_011753657.1\|175512_176310_+\|glycerophosphoryl-diester-phosphodiesterase	gnl\|CDD\|176524	cd08582, GDPD_like_2, Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of uncharacterized bacterial glycerophosphodiester phosphodiesterase and similar proteins. They show high sequence similarity to Escherichia coli glycerophosphodiester phosphodiesterase, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	2.82858e-63
NC_008699.1\|WP_011753675.1\|191630_192209_-\|bacterial-proteasome-activator-family-protein	gnl\|CDD\|378489	pfam10759, DUF2587, Protein of unknown function (DUF2587). This is a bacterial family of proteins with no known function.	7.31157e-89
NC_008699.1\|WP_011753658.1\|176320_177259_+\|SEC-C-domain-containing-protein	gnl\|CDD\|235521	PRK05590, PRK05590, hypothetical protein; Provisional.	1.21813e-07
NC_008699.1\|WP_011753663.1\|181154_181745_-\|TMEM165/GDT1-family-protein	gnl\|CDD\|225030	COG2119, COG2119, Predicted membrane protein [Function unknown].	1.58196e-26
NC_008699.1\|WP_011753670.1\|187505_188780_+\|serine--tRNA-ligase	gnl\|CDD\|235461	PRK05431, PRK05431, seryl-tRNA synthetase; Provisional.	0
NC_008699.1\|WP_011753673.1\|190118_190913_+\|HAD-family-phosphatase	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.75701e-62
NC_008699.1\|WP_041546056.1\|185795_187370_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	1.24863e-51
NC_008699.1\|WP_011753664.1\|181744_182926_-\|nickel-pincer-cofactor-biosynthesis-protein-LarC	gnl\|CDD\|235249	PRK04194, PRK04194, nickel pincer cofactor biosynthesis protein LarC.	2.06474e-174

>NC_008699.1|WP_011753665.1|182922_183609_-|nickel-pincer-cofactor-biosynthesis-protein-LarB
MDQPVEPRTTDLGFARVDVDRAHRTGDPEVVYGSGKTPDQVVAILRALHDKHPERAVLATRVAADALDVVARALPGATVDRVARAVTVGPMPETRGTVAVVSAGTSDAPVAAEAALTVRVHGSAVDQISDVGVAGLHRLLGVRERLDAADCLVVVAGMEGALPSVVGGLTGVPLVAVPTSVGYGASLGGVAALLAMLNSCAPGIAVVNIDNGYGAGVHAARVARRSAR
>NC_008699.1|WP_011753664.1|181744_182926_-|nickel-pincer-cofactor-biosynthesis-protein-LarC
MTTAWVDASAGASGDMLLGALVGAGVPVAVLQAAVDAVAPEPVTLRVEHVRRGGLAATRCHVEVTDTARHRTWRDVRTLLAAADLADDVRGLALRVFERLATAEATVHGTSPDDVHFHEVGALDAIADVTGVVAGFVHLGATAVTVSPVAVGSGSVSTAHGLLPVPPPAVAELLRGVPSYAGAATMETCTPTGAALLTTLATAYGPQPAMSVDTIGVGAGGRDPEGHPNVLRLFVGVPADAGGGPLLLECNVDDLDPRVWPAVIAALLEAGASDAWLTPILMKKGRPAHTLSALVDAGRAAGVRAAIFRQTSTIGLREQPLTKHALEREIVAVDVDGQRIAVKLARHDGAVVNAQPEYDDVARAAADLDRPVADVLAEAVARGRAFLTPGDKI
>NC_008699.1|WP_011753663.1|181154_181745_-|TMEM165/GDT1-family-protein
MDPVVIGLTFLAIFVVELPDKTFLATLVLATRYRPILVWLGVGLAFAVQTTVAVLLGHAVSFLPDDAVRAGAALMFLAGAVILVREGRGHQQAAAEDTPAPTRDRHGLQAVVASFLVLFAAEWGDLSQLLTISLVAKYEQPFSVYAGALGALLVVSGLAVLAGRQLQRFISLHVLHYVGAAVCLTLATFTAYDLLA
>NC_008699.1|WP_011753662.1|179898_181122_-|arginine-deiminase
MASPHGADSEVGTLQTVMLHRPGNELKRLTPRNNDRLLFDGIPWVSRAQEEHDAFAEALRARDVEVLYLTDLLTETFASDTAREHAITTALAGLHLGDTMRGYLTGFLHDAAPAELTGYLTAGIRNDEVRGGRGLVTSLLARDDFLIDPLPNLLFTRDSSVWVRDRVAVTSLAMPARARETQLTELIYTEHPRFQGTRKIHGWHHEHVEGGDVLLLAPGVIAVGVGERTTPAGAERFARQVFHADLAHTVLAVPIAQERATMHLDTVCTMVDVDKIVMYPNIADSLQAYAVTLAERADDDHDLVLAVAGPEPFLVAAAKAMGIDTLHQIDTGLDPVTAEREQWDDGNNTLALAPRVAVAYERNDETNDRLEEAGIEVVRIAGSELGSGRGGPRCMSCPIAREPLPAG
>NC_008699.1|WP_011753661.1|179429_179804_-|cyclic-nucleotide-binding-domain-containing-protein
MAESFYDAFAPEEIARIAAAGTRVHVPEGWSPIWEKTPADKAYIILDGTVSVRHRGEEIAQLGAGEIVGEAAIVNHSLRTASIVALTPLELIHFTDEAVRRLCAEMPAFKTALEAVAVERFGRN
>NC_008699.1|WP_172419801.1|178260_179397_-|adenylate/guanylate-cyclase-domain-containing-protein
MAGAEETVEELLLGALPHLTRGEVAERAGLPIEVAEQLWRLLGFARTAPDDLAFTEADVEALRLTRELIELGILGPDSQAALVRTWGRSYARLAEWQTSLLADIAVADADPGRRLTELAESVLPRVEALQSYVWRRHLASATGRALAAESAAAPVSPLAVCFVDIVGYTSRSKALDQAELVGWLEQFEDAATGVVVDHGGRIIKTIGDEVLFVADRAADAAEAALRLTARGSDEADPFPAVRAGIAYGDVVSRLGDVFGPTVNVAARLTSLARPGTVLVDDGCYAALTGRADDSDQASDQASDQGSDDSGDEGSAGADPVDETGTERDDAGDGTGSDSGDEAGAGAPYTFRRMRRASVKGYSRLQPWVLRRLPLPTRE
>NC_008699.1|WP_011753659.1|177385_178240_-|hypothetical-protein
MENVLLATFELLPQGEDGGDLLPRELARLGIEARWAVWTDPEVDWSRADAVVVRSTWDYHRRLPEFLAWADRVAATTRLVNAPDVLRWNADKRYLLDLADAVPVVPTRDVPPDGLVAGLADGLAEHGTVVVKPRVGASGVGVVVAERSDDLRLAGLTAGPWLVQPLVTSVRTEGEASVFVFAGRAVSQLRKVATSGDVRVHEEYGGTTTPVPLDAEAAALAERAVAVAGEHCGPAPAYGRVDLLHHHGRLVVSEVELIEPGLYLDLLPGNAEALAAALAAVLVT
>NC_008699.1|WP_011753658.1|176320_177259_+|SEC-C-domain-containing-protein
MAKKSRTKARDHQPASGEVGPRQPCPCGSGKRYKACHGAAGGAPAPFVNRPFEGLPSECDIVAMRELVPAATAPLTLVDHADRTVQLCTLLPMAAPAMVRDSGEIWLGLQVQHNFGDPARDLGAVLAKALTADAGIVGLTDPPGEGPRLQDLVTGDRLAVTVHEGFEFWIGDVEESERAGMAAALEQANTAAMPTARLTTVEAAYWTDVGTKEHLRWVLPEPEDRLLDALARLHAAGNDGLVAGSRFVGMFRAHGLLAPVWDLPLGTGPEPLEEPAERFAADLAQALADTSDLTADERAARSGLANRQVTIR
>NC_008699.1|WP_011753657.1|175512_176310_+|glycerophosphoryl-diester-phosphodiesterase
MRPQVVAHRGASYENAEHTLGAYIAALDAGADAVECDVRLTADGHLVCVHDRDLRRTARTRGLVSTMELAELDQLDFASWKNPWADLDDEAPLRDERLDRVLTLRTLLETIADYDRPVEVAIETKHPTRYGGLVERRLIEQLRRFGWDRPGAPVRVMSFSWTALQRVERLAPGVRLVMLLEHARNWPALRRLVGPDWLVGPGIDELMDHRRLGPRITRSGHDLHVWTVNTPVELDLCLELGVKAVITDRPAYVRDLLDQREADPG
>NC_008699.1|WP_011753656.1|175147_175516_+|methylmalonyl-CoA-epimerase
MDLVQIAQRADDLERATAFYTLLLGSPPVATYEPPGLVFFDLGGVRLLIEHGAPSATVYLRVEDIDAAVAQAREAGTEVASEPHVIFAHADDTLGPRGTDEWQAFIRDSEGNLVGLVEHRPR
>NC_008699.1|WP_041546055.1|183810_184683_-|prephenate-dehydratase
MSTVTRRIAYQGEPGSNSHQVCKQHYPDWEAVPCASFEDVFAAVEGGPGVAPAADLAMIPIDNSIAGRVADIHHFLPGSRLHIIAEHFLRIRFHLLGVPGSSLDTITTVHSHVHALGQCRKVIREHGLKPVIAGDTAGAAREVAELGDPTLAAISPPLAAEIYGLDVLEEDVEDEEHNTTRFVVLSPDLVQAPSGNGPVVTSFIFNVRNLPAALYKALGGFATNGVNMTKLESYMVGGEFAATQFLAEVDGHPDDIGVKRALEELAFFTTDIKVLGVYPADPFRAEVSSP
>NC_008699.1|WP_140403777.1|184809_185208_+|DUF4446-family-protein
MLAVLVAILALLVAVVVGLVTLRRTAPGRGDGADALPEDVHGLRQEVAALRAEAAAALRHLAVVRYDAFGDMGGHLSWSLALLDDGGDGVVLTSIHGRSDARTYAKGIRGWRCDQQLSPEELEAVANARPRG
>NC_008699.1|WP_011753668.1|185228_185696_+|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MNPLRWLALRLGAQPWLPRFARVIVTLDLTTQRLSRGRVDLLTFAGLPELLLQVPGRRTGVLRSTPLLCVPHGDGWLVAGSNWGAPTPPAWVANVLGADEPLVTFRGHTVAADALLLTGPDRDEAWAVMTGTWPNYAKYAERTGRELPVILLTPR
>NC_008699.1|WP_041546056.1|185795_187370_-|phosphatase-PAP2-family-protein
MLDRPRATLLTWTAALLVMFVLVTIAVQTGWGPVTSIDNRGQGAETWAVDERWLRLPLRWIEVGFGAIGTWVIVGVLAVLLFVRQHRRAAVYAVGVVAVTKIATTILKAVFGRHRPDWQNPEHLLDSNAYPSGHSSTIVALVGVAAVLVMMLVRRRSARHTAYALLAVLAVVVGLDRVLLGRHFPSDVVGGALLGAIVVLLGIVVQNPLPRSHAASVEPLPEVFGSEHRLTVILNPVKVEDVGQFEALVTAMAAEAGWSAPTWHYTTVEDPGTGMAEAAAVAGTDLVLVCGGDGTVREVCAELAGTGIPVGIIPAGTGNLLARNLDIPLYLRAAIDVALTGQDRAIDLVEVSGDGFEDTHFMVMAGMGFDAAIMEGVNEDIKKRVGWLAYVLSALKSLMFPAVRVEVSVDGGEFTRHRARTIVVGNVGFLQAGMPLLPDAAIDDGVLDVVMLHPRRFLSWIPLAYRVLARRPRTDELVNRMTGHTVVVRASTDTPRQLDGDSIGPGRELRMTCVHGRLLVRVPR
>NC_008699.1|WP_011753670.1|187505_188780_+|serine--tRNA-ligase
MIDPRVLRDEPDRVRAAQVKRGLSDEVVDHALSADGERRRAIAAFEAKRAEQKQLGKLIPQAQGEEKQALLAQTKTLAAEVKQAEAAQAVAEEAWQAALMSIPNLAADEAPAGGEDDYVVLEEIGTPRDFAADGFEPRDHIELGRMLGAIDLDRGAKVSGSRFYFLTGAGAELELALVNLAMQQARESGFTPVIAPSMVKPRAMDGTGFLGQAADDVYRIEGQDMYLVGTSEVPMAAYHSDEILDGGALPLRYAAFSPCFRKEAGSHGKDTKGIIRVHWFDKVEMFVYTTTEESYAEHQRLLAWEKEFLEKLELAYRVIDVAAGDLGLSAQRKFDCEAWIPTQGRYRELTSTSNCTEFQTRRLDTRGRFGSEIRPISTLNGTLCAITRTIVAVLETHQQADGSVRVPKALQPWLGREVLEPVTT
>NC_008699.1|WP_011753671.1|188776_189625_+|HAD-family-phosphatase
MSGPVSGWRPRLVALDIDGTILKWVEGSGTTREEISPTVKESVHRVLAAGAHVVLASGRSPHGMTNVADLLELHGPGRDRLWIVASNGAVVFRYPPLDVVHEETFDARPAVEAILDRHPTALVAVEERGVGYRVNSHFPDGELSGDMIVTEIDELLAVEVSRVIIRDPESTADEFVALAEELGLQGTNYVVGWTAWLDLAPVGVSKASGLEYVAKQLGISSDDTLALGDGRNDVEMFEWAHRGVAMGQAIEEVLAKADAVTGSVYEDGVATELDRWFGDGRA
>NC_008699.1|WP_011753672.1|189624_190122_+|GNAT-family-N-acetyltransferase
MLPDGPPEVVTSERLRLPLWTPQDAADIRAGRHREGWHRDYPRPDDRDAATIYRSGDPWAPRHVVRGVTALGSIGFFGPPQAAADGVPEVEVGYGLVAEARGWGFATEALRALLAETDRAGVRVRASVDPANTASVRVLAKCGFTELRGSNEDGELVMARPLPAS
>NC_008699.1|WP_011753673.1|190118_190913_+|HAD-family-phosphatase
MTRPRLVATDLDGTLVRSDGTVSPYTREVLTAVEAAGAIVVFVTGRPLRWAEEVFDHVGEHGLAVVANGALVWDVGRHDVHLLRPIDPALGLEASELLRAALPGTTFAVETVDGIGLEPEFLERHPLPEDARRGPLTELFDRPAVKLLARHEELGPQEFWDLAEEALGGRLVITWSSASALLEISAPGVTKASTLALLCADLGVEAEEVIAFGDMPNDLPMLAWAGSSYAMADAHPTVTAAADHVAPGHDEDGVARVLAGVFDL
>NC_008699.1|WP_041546058.1|190955_191534_+|hypothetical-protein
MTRLPRLLLAALLLAGGGVVATGAMAAPALACPASRTGLDQLTMQADDVFTGAVEDRARQGRTIVYTVTVDRVYKGDLDGTEATVTTPARARACGLPDLRTGTDYVFFTQGADLETTSTAGTAPAAATLLRRVERLLGEGHPATPPTPPEATFTLVGEQPTSFERVAAPGAALVIAGLLGLLLVAGLSRRRA
>NC_008699.1|WP_011753675.1|191630_192209_-|bacterial-proteasome-activator-family-protein
MNEQPGQDEQEQQVVIIGPDGHPMGSVPASALEPGESGDEDDERAITDLVEQPAKVMRIGSMIRQLLEEVKAAPLDEASRNRLKEIHQASIKELEAGLAPELVEELDRLTLPFTEDTVPSDGELRIAQAQLVGWLEGLFHGIQTAIYAQQMAARAQFEQIRKALPQAMNPGAGQPRPDGEAPRPGDSGGMYL

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Crispr_ID: NC_008699_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_3

238672-238757

Orphan

Consensus_repeat	Method
TTCCCCGGTTAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_3

>merge|NC_008699|3|238672-238757|CRISPRCasFinder
TTCCCCGGTTAACCGGGGAAACCGGAACCGTTGGGCCGAAACTTCGGGGCAGAAGTTCCAACTTCCCCGGTTAACCGGGGAAACCG

>NC_008699|3|3|238672-238757|CRISPRCasFinder
TTCCCCGGTTAACCGGGGAAACCG	GAACCGTTGGGCCGAAACTTCGGGGCAGAAGTTCCAAC
TTCCCCGGTTAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011753716.1\|236744_237353_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_008699.1\|WP_011753722.1\|243143_244100_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_008699.1\|WP_041547018.1\|231041_231740_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223487
NC_008699.1\|WP_049774518.1\|245993_248345_+\|carbon-monoxide-dehydrogenase-large-subunit	unknown	unknown	gnl\|CDD\|131469
NC_008699.1\|WP_011753724.1\|244516_245392_+\|xanthine-dehydrogenase-family-protein-subunit-M	unknown	unknown	gnl\|CDD\|224238
NC_008699.1\|WP_041546064.1\|244241_244517_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753718.1\|238855_239734_+\|xanthine-dehydrogenase-family-protein-subunit-M	unknown	unknown	gnl\|CDD\|224238
NC_008699.1\|WP_011753712.1\|231837_233535_-\|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein/permease	unknown	unknown	gnl\|CDD\|213186
NC_008699.1\|WP_011753720.1\|240197_242573_+\|carbon-monoxide-dehydrogenase-large-subunit	unknown	unknown	gnl\|CDD\|131469
NC_008699.1\|WP_011753719.1\|239724_240201_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NC_008699.1\|WP_011753710.1\|230365_230893_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753708.1\|227623_227929_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753717.1\|237462_238644_+\|flavin-reductase	unknown	unknown	gnl\|CDD\|214900
NC_008699.1\|WP_011753714.1\|234533_235880_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|379197
NC_008699.1\|WP_011753715.1\|236112_236748_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_008699.1\|WP_011753721.1\|242553_243147_+\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|133025
NC_008699.1\|WP_011753713.1\|233537_234467_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119324
NC_008699.1\|WP_011753709.1\|228225_230379_+\|ATPase-AAA	unknown	unknown	gnl\|CDD\|226482
NC_008699.1\|WP_011753727.1\|248341_249241_+\|XdhC-family-protein	unknown	unknown	gnl\|CDD\|379212
NC_008699.1\|WP_011753725.1\|245388_245934_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011753716.1\|236744_237353_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	6.37483e-10
NC_008699.1\|WP_011753722.1\|243143_244100_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.68365e-30
NC_008699.1\|WP_041547018.1\|231041_231740_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	3.12349e-100
NC_008699.1\|WP_049774518.1\|245993_248345_+\|carbon-monoxide-dehydrogenase-large-subunit	gnl\|CDD\|131469	TIGR02416, Carbon_monoxide_dehydrogenase_large_chain, carbon-monoxide dehydrogenase, large subunit. This model represents the large subunits of group of carbon-monoxide dehydrogenases that include molybdenum as part of the enzymatic cofactor. There are various forms of carbon-monoxide dehydrogenase; Salicibacter pomeroyi DSS-3, for example, has two forms. Note that, at least in some species, the active site Cys is modified with a selenium attached to (rather than replacing) the sulfur atom. This is termed selanylcysteine, and created post-translationally, in contrast to selenocysteine incorporation during translation as for many other selenoproteins. [Energy metabolism, Other].	0
NC_008699.1\|WP_011753724.1\|244516_245392_+\|xanthine-dehydrogenase-family-protein-subunit-M	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	2.3673e-73
NC_008699.1\|WP_011753718.1\|238855_239734_+\|xanthine-dehydrogenase-family-protein-subunit-M	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	1.03039e-83
NC_008699.1\|WP_011753712.1\|231837_233535_-\|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein/permease	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	6.30039e-87
NC_008699.1\|WP_011753720.1\|240197_242573_+\|carbon-monoxide-dehydrogenase-large-subunit	gnl\|CDD\|131469	TIGR02416, Carbon_monoxide_dehydrogenase_large_chain, carbon-monoxide dehydrogenase, large subunit. This model represents the large subunits of group of carbon-monoxide dehydrogenases that include molybdenum as part of the enzymatic cofactor. There are various forms of carbon-monoxide dehydrogenase; Salicibacter pomeroyi DSS-3, for example, has two forms. Note that, at least in some species, the active site Cys is modified with a selenium attached to (rather than replacing) the sulfur atom. This is termed selanylcysteine, and created post-translationally, in contrast to selenocysteine incorporation during translation as for many other selenoproteins. [Energy metabolism, Other].	0
NC_008699.1\|WP_011753719.1\|239724_240201_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	4.65416e-75
NC_008699.1\|WP_011753717.1\|237462_238644_+\|flavin-reductase	gnl\|CDD\|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	4.74085e-52
NC_008699.1\|WP_011753714.1\|234533_235880_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|379197	pfam13458, Peripla_BP_6, Periplasmic binding protein. This family includes a diverse range of periplasmic binding proteins.	6.47399e-34
NC_008699.1\|WP_011753715.1\|236112_236748_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.76242e-10
NC_008699.1\|WP_011753721.1\|242553_243147_+\|nucleotidyltransferase-family-protein	gnl\|CDD\|133025	cd04182, GT_2_like_f, GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	8.0747e-46
NC_008699.1\|WP_011753713.1\|233537_234467_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	4.58088e-46
NC_008699.1\|WP_011753709.1\|228225_230379_+\|ATPase-AAA	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	9.8654e-48
NC_008699.1\|WP_011753727.1\|248341_249241_+\|XdhC-family-protein	gnl\|CDD\|379212	pfam13478, XdhC_C, XdhC Rossmann domain. This entry is the rossmann domain found in the Xanthine dehydrogenase accessory protein.	4.32389e-29
NC_008699.1\|WP_011753725.1\|245388_245934_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	7.2086e-79

>NC_008699.1|WP_011753717.1|237462_238644_+|flavin-reductase
MSDPNPAHFRQVLGQYPTGVAVVTALDESGAPLGMTVGSFTSVSLDPPLVAFLPDQGSSSWRALRASGDRFCVNVLGADQEDVCRAIAVRKVDKFAGIPWRPSPAGNPVIDGAVAYLDCTTEQVHDAGDHHIVVGRVHQLDLVGGDQPLLFFRGGYGSFTPLSLASGDSDLLDHLRLVDLARPQMDRLAARFDTEVTAIALVRDELVLAAAAGRTRLAVAPTRVGQRLPFMPPLGSCFAGWGDDAVRAAWVGGLSDLVDPDTRDAVRAVPGLVRRRGYSIALGHGDGARLETLSTRFHEGDAQVSKAALREAIAQSVSGYNPASYGAGPVELRSLSAPVFANDGRVAFTLTLWGPPGAIDAAEVDRHVEELLAATGAATIAIDGRVPLDAAIA
>NC_008699.1|WP_011753716.1|236744_237353_+|TetR/AcrR-family-transcriptional-regulator
MTAAEGQDGSRQRIVAAAAEIAAEAGYEGTTISKVVKRSGLPVSSVYWFFKDKDELIAEVVRSSFDTWIGDQPTWDPLPKGVSVGDGLRAVLDKSALSLAAAPDFLRIGLMLTLERRETEPAARTLFLDIRIAIEDELTRWFAAAIGTRKVRRAPDLPRRLARMVIAGTDGLFLAHQIHDVADTHEYVDILVTIVESAIAAA
>NC_008699.1|WP_011753715.1|236112_236748_+|TetR/AcrR-family-transcriptional-regulator
MPRKTTRRHRQGDESRHRILATTLEIAAERGYEGTTVGLVTERTGLPASSVYWHFKNKDELLAETLEYSYRQWREATPTWEGVDDEGVPDLRAEVRRRLRAASRALLESPEFWRLGLMLALERRAKEPAARGRYVEVRLETAAAIARWWASVLPAELRERDDELPDRLARVHLALMDGFFVGRRADPRWDVGAMVELMAEGMAAYVEGVAR
>NC_008699.1|WP_011753714.1|234533_235880_-|ABC-transporter-substrate-binding-protein
MSVLPSTRRGPRARSTSRSVRRSVALGAALALALSLSACGEDKPEVSAAETQAQAADLVDLLAIPEGTDLGGDLTWKMGAALTLSGPSAANGESMKNAIDLAVEQVKAAGGPTIEVLTKDIKGPDPVAAKQAAEELAAAGVPAKITSMGDGLGAMLENTAKDQILSLDGVGGAQVFTQGVDYFFGTREVAPSDAVPGALEWLKQSDPEATTVGLVGVDLGPFNDPIKADITAKIDASGLQFNGLWETVAPTSQDYASVISKIKENQPDMLLVAFGGGAPGAFAAQAKAAGLDSLLMGIEFTEEAVKASKGVLDSDGFHFAMDYFDAENPANPLAELFVDSYEKAYGVKPDFYAANAYEEVLMFWDLVRRVVADGGDPNDSAALKAALEADPTFASVYGAGEGDGPGTLAIDLKTHGVASRPMGVYEYQDGAVSTLATFDVNAAGFALN
>NC_008699.1|WP_011753713.1|233537_234467_-|branched-chain-amino-acid-ABC-transporter-permease
MDSLISADFWQLTANGLVRGSFYAALGAGLALVLGVTARFHFAYTLTYTFAPYAAFLAMDRQGVSFWPAALLGLAAAVVLSVLIELLVYQPVARRAGDRAMLAVLVTSIGVSAAGIAALQLVAGTSSVPFYGPAMTISEYGPVRVSSFELYQVLTCVGLVVALAAFLALTPLGRSIRAVRSNPGLAGLLGIGVTRVNLTVFAIAGLFSGAGALWYGLLYTVEPVMGDKVVIYGFVVAFLAGTRTSPLRALPVGLGLGLLEQWSSMWVSVQWTQTAVFTVLVVYLVALSGRGRWGRLLSPRPRARLEKAV
>NC_008699.1|WP_011753712.1|231837_233535_-|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein/permease
MWLNYLVQAVLLASLALSVNLLVGYAGQVSVAHAAFAGVGGYTIAYLTTARDWPFVTALVAATLIAAAVGVVIGLIALGLAEEFLILMTLAFSLAVIGIFATFDALGGVMGITNVTGLSILGHEMTGPRDWLVPALGTLVVTFAVCWRIGESPYGRVLKGIREDSDATRSLGKNTFAYKVGIFAITAGMAGWVGGLYSGWLGLATPSAFGFPLAMSVFAMVIVGGSANLFGSVLAAGVLTLIEPTLREALAMQSSQAALVQIVLYGALLVVMMILRPQGLLAERFRHVTPPASGPVELVAERGAPVVRRLDAHPVVLRAEGLEKRFGGIVAARNLSLELRRGTITALVGPNGAGKTTAFNLLTGAIAPDRGSVLLDGQELVGRRPDEIVRAGLVRTYQDVRLLGRLTCLENVMLGVPDQHGEHLGRLFVPGRAVSRADRAVAERALEWLGFVGMAEQAGVPTEALSYGQTKLVSLARALATEAPVLLLDEPASGVDSAWVETMLRMIDAVRAEGRTVCLVEHNLDVVRELADHTYFMELGEITASGTIAELTSSARLTEAYFGAQ
>NC_008699.1|WP_041547018.1|231041_231740_-|ABC-transporter-ATP-binding-protein
MLRVRDLAAAYGPKQVLYGVDLEVRAGEIVALMGHNGAGKTTTIRTVLGALRARSGEVSVAGEDLTGQPVRRLVRAGVALVPSERFVFPDLSIRDNLLLGAANAPRDADSAARLREVEEAFPLLSERSSQLAGQLSGGQQRMVSLGIALMAQPRLLLLDEPSLGLAPSIVEAIFGRLRALATSSGLGILLLEQNVKQALQIADRAYVMRSGRVILEEPAAQMRRRPDFWDLF
>NC_008699.1|WP_011753710.1|230365_230893_-|hypothetical-protein
MEKIMWLVLGGTTFAAALRARTSRRARYVARGALGLLFLAFGVNAIYLALDNGYYDDFADPSPFGFVRDTWESVVLPHQGVFIGLLIGFEAAAGVLVLSGGRWTQAGLIGLIGFHVGQLAFGGMLWAWAAVMLVALVLLLRAERHPPEPSAAGPDRPRHRHRDRGVPTAGGLTGS
>NC_008699.1|WP_011753709.1|228225_230379_+|ATPase-AAA
MEPTTTSAFDLPAHLAAKADPGLIGRDERHFAAIAESLKVTIAELTDRLDAARRAPGGNGQEALERDQEVHRLTARLRALRRYGLDLCLGHVVGADDGEPAYVGRLGLTDTAGRRLLLDWRSPAAEPFFGATHANPMGLASRRRYRWTRGRVTDYWDEVFTADGLDGHAAALDDQSAFIASLGATRSPRMRDVLGTIQADQDAIIRASSRGALVVDGGPGTGKTVVALHRTAYLLYADPRLGHRRGGVLFVGPHQPYLAYVSDVLPSLGEEGVQTATVGDLVPEGATAPPEADPAVARLKASARMVAAIEPAVRLYEELPTEGMAVETPYADLWVSVEDWAEAFGAADPALPHNEARDDVWLALVAILLDKADPDDVPVDRLRRSLAHHEGLVSAFDRAWTVIDPYDLVGDLWSVPAYLRRCAPWLEPDEVRLLQRADAQAWTVSDLPLLDAARQQLGDPGASRRRRRREAALQAQAEEMSHVVDHLIATDDSEMQVMSMLRVEDLQGALVDEDVVPAADPDQLAGPFAHVVVDEAQELTDAEWQMLLLRCPSRSLTVVGDRAQARHGFAESWQERLQRIGLDRVEVAALNLNYRTPAEVMAEAEPVIRAALPDANVPTSVRRSGIPVHHGSVADLEVIVDDWLAEHAEGTVCIVGDHPLAPRPRVRSLAPELVKGLEFDLVVLVDPGRFGDGVEGAVDRYVAMTRATQRLVLLTSR
>NC_008699.1|WP_011753708.1|227623_227929_-|hypothetical-protein
MDTRSADLDTVSTRAGTATLGLGLLFLAATIFIFVLSLSDLVDPPTWVRVLGLVWLPLGFFGAPLTYAVARAGPGRNRGRLGLALMLVPLAAFVALLFVAG
>NC_008699.1|WP_011753718.1|238855_239734_+|xanthine-dehydrogenase-family-protein-subunit-M
MQVPAPIEYERATSVEHAIGLLARLGDEARLIAGGHSLLPMMKLRLANPEYLVDINDLHDELSYIDIGPTGVRIGALTRHRELLESDALAEVCPIFRDAERVIADPPVRNRGTLGGALCQADPSEDLSSVCTTLDASCVIRGRDGERVVSMDDFHLGPYETVVRHDEMLIEVRIPVRPHGSSAYAKVDRRAGDWAVTAVGAALWLDEHDSIADARVGLAAVGPNTTGIPAISAALRGRAPSEEAWAEAGAIAAASCRPVTDGRGSADYKRHLAGELTRRTLRTAWERVVTWR
>NC_008699.1|WP_011753719.1|239724_240201_+|(2Fe-2S)-binding-protein
MEVTLTVNGEVVTRDVEARLLLVHFLRDDLGLTGTHWGCDTSNCGSCVVLYDDEPVKSCTVLTAMAAGHDVRTVEDLEQDGELDPVQQGFMECHGLQCGFCTSGMLMSARALLDRDPDPSEEDIREAISGQICRCTGYASIVRSVRWAADHPEGRIEA
>NC_008699.1|WP_011753720.1|240197_242573_+|carbon-monoxide-dehydrogenase-large-subunit
MTATVPIGHGRMLRKEDRRFVRGRGKYLDDIALPGMLHLAVLRSPVAHARILSIDTLAAEAHPKVKAVVTGALLAERGLAWMPTLSGDVQAVLATDKVRFQGQEVAFVVAEDRYSARDALELIDVEYDVLPPVVDVRRALDADAPLIRDDVAGKTDNHCFDWETGDAAATDAVFDRAEVVVRQEIVFPRVHPAPLETCGAVADYDRVEQKLTLWATTQAPHAHRTLYSMFAGLPEHKIRVISPDIGGGFGNKVPIYPGYVCAIVGSMVTGRPVKWTEDRTENLVASGFARDYVMQGEIAATRDGRILALRSHVLADHGAFNGTAAPRKFPGGFFGVFTGSYDIEAAYCSMTAVHTNKAPGGVAYACSFRIAEAVYLVERMVDLLADELGIDPVELRLRNFIRSDQFPYTSRTGWVYDSGDYATTMQEALRIAGYDELRAEQAARRAAGDGQSLMGIGVSFFTEAVGAGPRKDMDMLGLGMADGCELRVHPTGSAVLRIAVQTQGQGHETTFAQLVAEELGIHPENIDVVHGDTDNTPYGLGTYGSRSTPVSGAAAVIASRRVREKARLIAAGMLEVAPDDLEWTKDAAGGRFGVRGVPGASVTIEQVAMRAHGADELPEGVEGGLDAQVSYNPDNLTYPYGAYICVVDIDPGTAVVKVRRFVAVDDCGTRINEMIVEGQIHGGLTDGVGMALMEYIGYDEHGNCLGGSLMDYLIPTAKEVPDWETGMTVTPSPHHPIGAKGVGESATVGSPPAVVNAVIDALAPYGVRHADMPLTPSRVWEAMHGRATPPQ
>NC_008699.1|WP_011753721.1|242553_243147_+|nucleotidyltransferase-family-protein
MPRLLSDATALVLAAGGSSRLGRPKQLLPLGGATLLDATLSAVRRCGFGQVVLALGGAADEVAATVDLSGVDVVRNPGFGAGCSSSIAAALPAISATSEGLVLMLGDQPEVSPAAVAAVAAVDADLAVCRYDNGLGHPFWLGRSRFGELANLHGDKAVWKLVDAAGDALVTVPVVGDVPADVDTEADYRALLARWDR
>NC_008699.1|WP_011753722.1|243143_244100_+|LysR-family-transcriptional-regulator
MTPTQLRAFATVVRLGSVKAAAAELEVSEAAVSLHVGQLRKELGDQLFNRTASGLAFTPGGLRLASRAVELLGLQDRTVLEVREAGVGRRMLRLGTTSLFAEYAAPGLIGLFADRARDLDVELSVHRARDFEQLLLTRTVDAVVGPRPATGDPALISKLFLNYQVLAVVGPEHPVTRGQPGIAMLRDQTWLLGPSAADDAGVIPGLLQRIGVPEERQQIFQSHAAALEEAKRGRGITLAVAFAVAQDLATGALVRVPGRPVQGQGSWNISILGGERATPAAEEMARFVTTPRATQAMLRGRGVTHGRFKPAVHVTLWS
>NC_008699.1|WP_041546064.1|244241_244517_+|hypothetical-protein
MPVESDGHSRGNPRMYELIENAPRSTSEGPGKSPTVWAFPEFVEFLKVAGQPVQGPWPPHQHPRPDPTDVESLPVAIPDPAAEPRHRTEGA
>NC_008699.1|WP_011753724.1|244516_245392_+|xanthine-dehydrogenase-family-protein-subunit-M
MYPSRFRYEAPRSIDEAIQLLHEGAGEAKVLAGGQSLVPLMKLRFAAPELLVDINNLPGLDHLDVAADGGIRVGALCRHRDLERSLEVARAQPVMAAAAPLIADPIVRTRGTLVGSLCHADPQGDWAAVVTALGGHVVAQGPGGRRSIPITDFVTGPFQNVLEYDEVAVEAVLPAPRARVAGGFLKLERRVGDFATAGTAVALELDGDRVTRAGIALTGVGSRTVDARAAAEALVGQPLTAEAIGRAADLAAEVAQPTSDHRGSASYKRHVIHTFVTRILTRVTQTSEAAA
>NC_008699.1|WP_011753725.1|245388_245934_+|(2Fe-2S)-binding-protein
MTSLFEEVPAAAAEGVPVRRITVRVNGTPRTADVEPRLLLAHLLRQGFKLTGTHTGCDTTNCGACTVLVDGLPVKSCTMLAVQADGHEVTTVEGLAGPSELHPLQEGFKDEHGLQCGFCTPGMMLAAKALLAENPDPTEDEVRFALSGNLCRCTGYQNIVKSVLWAAKQMNGASADEGSAE
>NC_008699.1|WP_049774518.1|245993_248345_+|carbon-monoxide-dehydrogenase-large-subunit
MGASRRRVEDNRFIRGRGHYVDDVVLPGMLHMEILRSPVAHARIVSIDTTRAWNMPGVRLVLTGEMMATRNLAWMPTLSYDTQAVLATDKVRFQGQEVACVIADDPYIAKDACEAIEVEYEQLPVIVNPTQAMAPDAPIIRDDKEGQADNVIFDWEVGDKEGTDRAFAEADHVSTIRMHYPRSHPSPLECCGSVADFDRATGKLTIYMTTQAPHIVRAAVALIAELPEHMIRIVSPDLGGGFGNKVPVYPGYVMTILASILLERPVKWIEDRSGNLISTGFGRDVYLEGELALRRDGKILAVRMHTDSDHGAFFGDAQPSKFKIGLLHSTFSCYDIPTAHLTARGVYTNKAPGGVAYRCSFRVTEAMFFQERMMQAAADELGIDQAEFRRMNFVRDDDFPHRTPFGFLTDSGQYAKCLQVGLDAIDYEGFRREQAEAAKQGRLLGIGISCMTEPLGAGNSREYDILGIKMFDSAELRVHMTGKAILRTGAKTQGQGHETTWAQIVAHELGLPADDVVVEEGDTDTAPFGMGTYASRSTPVAGAAVAMVARKIRAKARKLAAHLLEVSEEDVEWELGRFYVRSAPDRGVTIQECAMAAYSNMPDGLEPGLEANAYYDPPNLTWPFGCYIVTVEVDPMTGVWDVLRVVAVDDCGVRINPMIVEGQIMGGLTEAYAMSSMQFITFDADGNCIGSNFMDYLLPTAWETPGYELHEVVTPCPHHPIGAKGIGECATVGGPAAFVNAVMDALKQYGVRNVDMPLLPDRVHEAITQRHDVSGAPPIRTDA
>NC_008699.1|WP_011753727.1|248341_249241_+|XdhC-family-protein
MNEPDLIADLGGQEYAVATVVWRQAPSSGQIGSRAYVTADGHVHGWIGGACAEPTVIREAQRVIRDGEPKLLYLGASEDLVLPEGMTAIPMSCQSEGALQIYIEPVHPPVHLVVVGRSPMAQTLAALARALGWRTDLVDGPDFTGADIDQRSVVVVATQGHGDEDVVRHAASAMPAYVGLVASRKRGDAVLGYLAERGVPQHLLERVRTPVGIDLGRTSHQEIAVSILAELVQVRAAGGISAEPVRRTLPLLETPEALDPVCGMTVPADDAHFPAEVDGTTYHFCCVGCRDAFLAKVEA

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Crispr_ID: NC_008699_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_4

263408-263492

Orphan

Consensus_repeat	Method
TCGGCCGGCCGATGAAACTCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_4

>merge|NC_008699|4|263408-263492|CRISPRCasFinder
TCGGCCGGCCGATGAAACTCGACCCTGGACGATGAAGTTGCATCGTCCAGGCACGAGGTCTGTCGGCCGGCCGATGAAACTCGAC

>NC_008699|4|4|263408-263492|CRISPRCasFinder
TCGGCCGGCCGATGAAACTCGAC	CCTGGACGATGAAGTTGCATCGTCCAGGCACGAGGTCTG
TCGGCCGGCCGATGAAACTCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011753741.1\|257633_258317_-\|acyltransferase	unknown	unknown	gnl\|CDD\|100053
NC_008699.1\|WP_011753747.1\|263533_266875_+\|exodeoxyribonuclease-V-subunit-gamma	unknown	unknown	gnl\|CDD\|273633
NC_008699.1\|WP_041547027.1\|272736_274041_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NC_008699.1\|WP_041546070.1\|266880_270207_+\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273172
NC_008699.1\|WP_011753740.1\|256881_257550_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753739.1\|255983_256661_+\|NADPH-dependent-F420-reductase	unknown	unknown	gnl\|CDD\|273873
NC_008699.1\|WP_011753752.1\|274118_275576_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|131010
NC_008699.1\|WP_049774519.1\|255335_255929_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_008699.1\|WP_041547026.1\|270208_271954_+\|exodeoxyribonuclease-V-subunit-alpha	unknown	unknown	gnl\|CDD\|273631
NC_008699.1\|WP_049774188.1\|259105_260905_-\|GAF-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_008699.1\|WP_011753745.1\|261622_262567_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NC_008699.1\|WP_011753750.1\|272007_272631_+\|ACT-domain-containing-protein	unknown	unknown	gnl\|CDD\|153159
NC_008699.1\|WP_041546072.1\|277134_278469_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349949
NC_008699.1\|WP_011753742.1\|258373_258877_+\|PGPGW-domain-containing-protein	unknown	unknown	gnl\|CDD\|370603
NC_008699.1\|WP_011753754.1\|276110_277028_+\|1,4-dihydroxy-2-naphthoyl-CoA-synthase	unknown	unknown	gnl\|CDD\|181386
NC_008699.1\|WP_041546075.1\|278930_280460_+\|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|236507
NC_008699.1\|WP_011753737.1\|254150_255320_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NC_008699.1\|WP_011753753.1\|275611_276055_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|281995
NC_008699.1\|WP_011753744.1\|260988_261486_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380364
NC_008699.1\|WP_011753746.1\|262563_263382_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|372253

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011753741.1\|257633_258317_-\|acyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	2.23316e-36
NC_008699.1\|WP_011753747.1\|263533_266875_+\|exodeoxyribonuclease-V-subunit-gamma	gnl\|CDD\|273633	TIGR01450, recC, exodeoxyribonuclease V, gamma subunit. This model describes the gamma subunit of exodeoxyribonuclease V. Species containing this protein should also have the alpha (TIGR01447) and beta (TIGR00609) subunits. Candidates from Borrelia and from the Chlamydias differ dramatically and score between trusted and noise cutoffs. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_008699.1\|WP_041547027.1\|272736_274041_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.31769e-18
NC_008699.1\|WP_041546070.1\|266880_270207_+\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|273172	TIGR00609, RecBCD_enzyme_subunit_RecB, exodeoxyribonuclease V, beta subunit. The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	0
NC_008699.1\|WP_011753739.1\|255983_256661_+\|NADPH-dependent-F420-reductase	gnl\|CDD\|273873	TIGR01915, F420-dependent_NADP_reductase, NADPH-dependent F420 reductase. This model represents a subset of a parent family described by pfam03807. Unlike the parent family, members of this family are found only in species with evidence of coenzyme F420. All members of this family are believed to act as NADPH-dependent F420 reductase. [Energy metabolism, Electron transport].	1.92649e-66
NC_008699.1\|WP_011753752.1\|274118_275576_-\|alpha/beta-hydrolase	gnl\|CDD\|131010	TIGR01955, Transcriptional_activator_rfaH., transcription elongation factor/antiterminator RfaH. This model represents the transcription elongation factor/antiterminator, RfaH. This protein is most closely related to the transcriptional termination/antitermination protein NusG (TIGR00922) and contains the KOW motif (pfam00467). This protein appears to be limited to the gamma proteobacteria. In E. coli, this gene appears to control the expression of haemolysin, sex factor and lipopolysaccharide genes. [Transcription, Transcription factors].	0.000657367
NC_008699.1\|WP_049774519.1\|255335_255929_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.78032e-05
NC_008699.1\|WP_041547026.1\|270208_271954_+\|exodeoxyribonuclease-V-subunit-alpha	gnl\|CDD\|273631	TIGR01447, recD, exodeoxyribonuclease V, alpha subunit. This family describes the exodeoxyribonuclease V alpha subunit, RecD. RecD is part of a RecBCD complex. A related family in the Gram-positive bacteria separates in a phylogenetic tree, has an additional N-terminal extension of about 200 residues, and is not supported as a member of a RecBCD complex by neighboring genes. The related family is consequently described by a different model. [DNA metabolism, DNA replication, recombination, and repair].	1.59046e-144
NC_008699.1\|WP_049774188.1\|259105_260905_-\|GAF-domain-containing-sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.3146e-57
NC_008699.1\|WP_011753745.1\|261622_262567_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.31847e-84
NC_008699.1\|WP_011753750.1\|272007_272631_+\|ACT-domain-containing-protein	gnl\|CDD\|153159	cd04887, ACT_MalLac-Enz, ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains. The ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI, a malolactic enzyme (MalLac-Enz) which converts malate to lactate, and other related ACT domains. The yqkJ product is predicted to convert malate directly to lactate, as opposed to related malic enzymes that convert malate to pyruvate. Members of this CD belong to the superfamily of ACT regulatory domains.	3.33121e-21
NC_008699.1\|WP_041546072.1\|277134_278469_+\|hypothetical-protein	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	3.73852e-07
NC_008699.1\|WP_011753742.1\|258373_258877_+\|PGPGW-domain-containing-protein	gnl\|CDD\|370603	pfam09656, PGPGW, Putative transmembrane protein (PGPGW). Proteins in this entry are putative Actinobacterial proteins of about 150 amino acids in length, with three predicted transmembrane helices and an unusual motif with consensus sequence PGPGW.	1.67151e-16
NC_008699.1\|WP_011753754.1\|276110_277028_+\|1,4-dihydroxy-2-naphthoyl-CoA-synthase	gnl\|CDD\|181386	PRK08321, PRK08321, 1,4-dihydroxy-2-naphthoyl-CoA synthase.	0
NC_008699.1\|WP_041546075.1\|278930_280460_+\|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-alpha	gnl\|CDD\|236507	PRK09424, pntA, Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha.	0
NC_008699.1\|WP_011753737.1\|254150_255320_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	1.26686e-174
NC_008699.1\|WP_011753753.1\|275611_276055_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|281995	pfam04075, F420H2_quin_red, F420H(2)-dependent quinone reductase. This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.	3.79722e-41
NC_008699.1\|WP_011753744.1\|260988_261486_-\|cupin-domain-containing-protein	gnl\|CDD\|380364	cd02236, cupin_CV2614-like, Chromobacterium violaceum CV2614 and related proteins, cupin domain. This family includes mostly bacterial proteins homologous to CV2614, a Chromobacterium violaceum protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.94124e-08
NC_008699.1\|WP_011753746.1\|262563_263382_+\|ABC-transporter-permease-subunit	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	2.75688e-05

>NC_008699.1|WP_011753746.1|262563_263382_+|ABC-transporter-permease-subunit
MTATLTETGSLLVAADAPRPGFVDALRAEWVKLRTVRSTWWTLVATFVLGAGLTILMCWANADWLASAEADESPGSFITWGMMIAQITAVVLGALVVTTEYGTGMIRSTFAAVPHRGRVLAAKSLVLVAVLLVVGTGTALVGYLGGNYFLDREGIGMPLEGDVLRSMYGSGLYLAGIGLFTVAVGFLLRHTAGTISVVLALMLILGNMVNLVPGSFGEWLTKLMPGNAGSVVATPVSFNPNLLDAWTGFAVFGLEIAVLLAAAYVVLRRRDA
>NC_008699.1|WP_011753745.1|261622_262567_+|ATP-binding-cassette-domain-containing-protein
MIRAHALTKRFATEKGQSRVAVDGIDFVVGPGRVTGFLGPNGAGKSTTMRMILGLDAPTSGTVSVNGHRYAAAPAPLREIGALLDAHAIHPGRSARDHLRWMAASNGIPTTRVGEVLELVGLESVAGQRAGRYSLGMGQRLGIAAAMLGDPPVVVLDEPVNGLDPEGIRWVRTFARQLADEGRTVFISSHLMSEMALMADHLLVIGRGSILADCSMSEFMTDHAASYVRVKAPALGDVADLLGRRGLEVSRVDDELRVAGLDAPAVGELVFGHGLVLHELTLVRSSLEDAFMALTADSVEYHAAPEPARTGALR
>NC_008699.1|WP_011753744.1|260988_261486_-|cupin-domain-containing-protein
MKRLLLPLGGLALVCSGFGAGIAVSATAADDADRAAPVVVTREPLAEVTAPPGAPHRTLGLSKVVVMPGARLAAHHHPGAQLGYVAEGTLTYTVESGQARLMKGPGDDATLVRTIDPGETVKVRPGRWLVEEQGEVHHARNAGTTPIVIYIATLLRTGAPAAIAD
>NC_008699.1|WP_049774188.1|259105_260905_-|GAF-domain-containing-sensor-histidine-kinase
MVDTEVVHHEDARAGWSDSAARAVLQLMVESVAEMVGFEVATLSVVLDGDLVTMAYTGPEEFRDYLMAPDPVTVLDPVLARAESWGRFHFLAAEDYDATTLEGHWMVVADGQVDVPDAWHPMDVLVGLLTDDDGRLVGAMSVDRPVSGRRPDPAQRRLLERYAAQAERAVMTAFEREELVQQVAHSEAARRLIRSASMPDQASLQAVLDHTHRPLVEGFGAAGSWLQVLDPDSGGVGYARTREGEVVSLSDRMIALAHGLAPRLWEAQQVLVVAEGVEPSLSAESGAGPLLEEARRQIAELGLTSAMAVPLGAGTECLGFLVLSRRAQDPPWSTVEIGSALQIGYDLGAALMTVRALERERSLVRELQQLDDYRSQLIATLSHELRTPLTVISGNLELLGDLSLDETAQHYQEAMTRGTTRMQKVVDDLLLLARVSDPQHPLVQVPVDLNAVTRTTVDLLTAPALAKGLSLRLQHNPREHLVPGDPGELDRLLTNLVSNAVKYTPAGGTVTVTVERRGDAAVLEVADDGLGISEEDQVGLFRPFFRTTNPDALREPGTGLGLAIVATIVERHGGEVRVRSRLGVGTTFTVTFPAAAPAG
>NC_008699.1|WP_011753742.1|258373_258877_+|PGPGW-domain-containing-protein
MKAVVRRVALEVLGWVLVVAGIAALVLPGPGLLMIFAGLVILSQEYEWAERRVEPVKIRALRGAAEGVENWRRVTFSTAIAVGLVGCGAVWIWGPEAPGWWPVAERWWLPGGAATGVTQVASGFIAIGLIVYSYRRFRVRGEPVPELPDDDDDDNDDNDSRGAAERD
>NC_008699.1|WP_011753741.1|257633_258317_-|acyltransferase
MNPLARALGHGVLNRGVHAVWRWLDRAGEIVPGTHAAAAFGSFGAGSCIDFPPATLLNCRSIHVGSGVLVGRQATLSVGYGADDPNIPDRALVIGDRSSLGARVSITAHSSITIGESVFFGQSVFVTDASHGYQDPTRPIGEQFGAHQPVSIGSGSWIGHGAVILPGARIGRNAVVAAGAVVRGEVEDFAVVAGNPARVVRRLEPDVGWVDSRGDVRPVLEGLFGSD
>NC_008699.1|WP_011753740.1|256881_257550_+|hypothetical-protein
MNLTLATLVGLAGTLLAAGYTVPQFSKLRRMATAAGVSVAALASSTISGVAWTVFGVLEHDIWVALPAAVAVPATVGALVLAWLRGGSRERLWLPAAWLATVSLAGLATLWVGPTPATVVLGFSVALLVTPAALTAWRSRDVSAIAASAWALMILDALLAGAYGLLAGVDANLIYAAVATIGSLAVLLRIAVPAHVHARLVPLPALADAEVEVVPEDLSLVA
>NC_008699.1|WP_011753739.1|255983_256661_+|NADPH-dependent-F420-reductase
MSDLPESLAGTTVAVLGGTGPQGRGLARRFAAAGLPVVIGSRSAERAAATAADLAAATGGDVTGADNAHAATTGDLVVVAVPWEGHGELVGGLATELAGKVVVDCVNPLGFDKQGAFALAVEEGSAAQQAQALLPESTVVGAFHNVSAVKLEDPEVASVDTDVLVLGDVREATDLVQDLCATIPGVRGVYGGRLRNAHQVEALTANLISVNRRYKSHAGVRVTDL
>NC_008699.1|WP_049774519.1|255335_255929_+|TetR/AcrR-family-transcriptional-regulator
MPGTDSVNAVPPPRHQLLDELIELFLAEGFLEFGIGDLAARLRCSRTTIYRVAETKEQVVLAAVRGFFRRAAERIEAQVAAEPDPGARLAVYLTAVAEELAPASARFYADLQAYAPAAEIYEANTRLAAERVQELVGAGVAAGALRRVDASFVGAAVAQVMSAIQGGRIAAASGLQDAAAYRALAELVVHGVGGSTP
>NC_008699.1|WP_011753737.1|254150_255320_-|acyl-CoA-dehydrogenase-family-protein
MSASRLLPTDEAVDLIALVRQIAAEELAPRSAEAEATETFPRDVFAMLGRTGLLGLPYPEQHGGGGQPYEVYLQVLEEVGAVWASIGVGISVHALSCFGLATAGTAAQQAEWLPAMLGGELLGAYCLSEPHAGSDPAAMRTRARRDGDEYVLNGAKAWTTHGGHADFYKVMARTGDQRGDISCFLVPADTPGLSADPPEHKMGLTGSATATMRFDDVRIPAERLLGGEGDGLKIALAGLDAGRLGIAAVATGLAQGALDRAVAYAQERETFGRRIIDHQGLAFVLADMEAAVQSARATTLHAARLKDAGLPYGREASVAKLVATDNAMRVTTDAVQVLGGYGYTRDFPVERYMREAKVMQIFEGTNQIQRMVISRALDRSTAGTLTVAP
>NC_008699.1|WP_011753747.1|263533_266875_+|exodeoxyribonuclease-V-subunit-gamma
MTLQIHRASRTDVLADALGDLLRTPLADPFAEEVVVVPAKGVERWLTQRLSHRLGAGPRGDDGVCAGVRFLNPRSLVSLLLGRERDDPWDPERLVWPLLATIDESLGEREFATLGRHLGHGVDGADGELRRNRRYSVALRLAHLFASYALQRPSLVTAWREGRDGEHGGEQGLPPDLAWQPELWRRLIAQVDAPPPDVRHAQTCAALQAGGDGLPLPDRLSLFGHTRIPVTEVALLKALGEHRDVHLFLPQPSPVLWDDLADLGGPGGVVPRAADDSVERVGHPLLASLGRDARELRRLLDGVSSEEVRPPAGTPTGSTTDPVTLLGWLQHDLRANHAPSYDERSTRELDPDDHSLQVHACHGPARQVDVLREVLVGLLEDDPTLEPRDVLVMCPDIETYAPLISAGFGLATTDGHPAHRLRVKLADRALTSTNPLLAVAGDLLDLAGGRVTASDVLDLAGTDPVRRRFGFTDDELDRVSRWVARAGVRWGLDEESRAAFRMERFPHNTWRTGLDRILLGVAMSGDDHHHLGRGLPLDDVASSEIDLAGRLAELVARVDRTLTVLAGARTVADWATGLRDGVRSLVDVAADDAWQVPQFERELGRAAASSHEGGLELRLADVRAMLESRLAGRPTRANFRTGSLTVATMVPMRSVPHRVVCLVGLDDGVFPRAGAVDGDDVLGRHPLTGERDVRSEDRQLLLDAVLAATEHLVITYSGADEQSGASLPPAVPLGEILDAADRTTNAPVRDRVLTRHPLQPYDARNFTRERPFSFDTAALAGARSARGVRREPPPLLDGPLPPRLALDGRAADVSLQDLRDFLGHPVRAFLRGRLDVATPFEPDDLADAIPVSLDSLEKWQIGDRLLRQLLAGQDPVAVLTAEQLAGTLPPRGLGTLALHEVAEECQRLWSRTADLRDGERRSVDVDVDLRDGRRLTGTVPGVYGSRVVSLGYSRLNARQRLHAWVDLLALSATYPDQHWTAHAVGKDRAGPKRALCGPLDHRAVGWLRDLVDLRDRGLCAPLPVPVKTGAAWADAHARELMGQDHPPVEAARREWETDPHNQFGITGEDADPYHQRVYGPAAPVEALLDAGLGEHAWAIWEPLLTGGERVGPL
>NC_008699.1|WP_041546070.1|266880_270207_+|UvrD-helicase-domain-containing-protein
MRPFAITDPLPAGTVLLEASAGTGKTWTIGALLTRYVAEGVARLDQLLVVTFGRAASQELRERVRAQLVEAERVLGDDPVAGDSGDPGDPGDPGDSELVTLLRSWGADERRRGHRRVTEALAGFDAATIATTHQFCSMVLDSLGVAGDTDSRARLVEDLDDLVKETVDDLYLRAFADAEPAFTHDEAMAIARAAVGDPQARLEPAGADRSTIAGRKVSFADAVRTELDRRKRRLGILSYDDLLSQLADALAQPGSAAAQRMRARWRIVLVDEFQDTDPVQWEVLDRAFSGHATMVLIGDPKQAIYAFRGGDVTTYLRAAETAQTRQTLAVNRRSDGPLLAAVQTLLAGAELGDERIVVHDVTAHHGESRLAGAPVPHPFRLRVVRRDTFGRRGGSTLTVGQVRPHVARDLALDVRRLLASGATWCGEPIRPRDVAVISYRHADLATVREALLEVGVPAVIAGGGSVFATPAAIEWLTLLEALEQPHRSTRVRSAALTCFFGHTAVELDARGDDLTDEVADTLRGWVELFAGRGLAAVLEAANVAGLPERVLAEIGGDRRLTDLRHIGEALHEVTLVARHGLPSLLTWLRGQVTEGRAGRGVERTRRLDSDAAAVQLVTIHASKGLEYPVVYVPALADRFVPKPTRPLFHDDGGTRCLDVGGARSDDGWADHCRRWADEEAGEWLRLLYVATTRAKSQVVAWWAPTKNAVASPLHRMLMRDGDGPDGEMSASVPAAPAVPDDDAVVTLFSRWRERGGPSPEAAIHADPGADPPRPATPDLAARTFTRTIDTEWRRASYSSLSRVEVAAPAGAVVSEPEITGKEDEALAPEAVPVAPLLASDVPSPMAGLPVGATFGSLVHAVLEHTDPEAVDLRAELLGHIDEQLGWWPVDLDREELADALVAVCDSPLGPLAAGTTLRQVTLGDRLREMEFELPLGDGLLGDLRPLLERHLPPGDPVRAYTAHLDGPLGEQTLRGYLTGSVDVVLRLRSEAGPRYLVVDYKTNWLGPTDEPLTAHSYASVALDAAMGHSDYPLQALLYVAVLHRFLRWRQPGYDPEQHLGGVLYLYLRGMCGPDTPSVDGAPCGVFAWRPPVALVEELSDLLDGGARD
>NC_008699.1|WP_041547026.1|270208_271954_+|exodeoxyribonuclease-V-subunit-alpha
MFEPVDEHDWRIATGATGLLATFNAAGVLTSSDVHVATRIGVLGGETDERMLLAVALTVRAVRRGSVCLDLAGVAATAPDLPWPDEWPVAGSPLVHAGVVRWDHELLYLDRYHRLERQVHDDLAARLALAPPAVDEQRLEAALARLGGGHFSEEQRAAVVAAVRRRTTILTGGPGTGKTTTVARLLALLADQAAGRGSRLSIALAAPTGKAATRLQEAVVTELAAVATAWPEAPALVGRLDGLTLHRLLGWRPDNATRFRHDRANRLKYDVVVVDESSMVELTMMGRLLEALRPDSRLVLVGDPQQLTSVGAGAVLSDLVAGYEGRPDSPVAALSTNFRSEEDIKSLAAALRSGDADEVIAVLRAPSEQVSWVETSDAAEVEAALRPDSLASARAVWAAARDEDAERALAELDRYRLLCAHREGLYGVRRWNHLVERWLAEDPDVEIYDEWYVGRPLLVTSNDYALDVYNGESGVVVRQDQRRRVFVAGSERLKEFAPGRLEAVETMHAMTIHKSQGSQADRVSVLLPDEGSRLLTLELFYTAITRARHHVRVVGSEAAVRAAVDTRAQRATGLRARLADG
>NC_008699.1|WP_011753750.1|272007_272631_+|ACT-domain-containing-protein
MPYLLRVELPDVPGSLGRLATAIGEAGGDIEAIEIVEKRHGGTAVDDVFLEMDPGAMPDSVVSTVNALDGVRVLWVGRYAAGGNLFLDLEAVEELTEDPEHALGRLIDRLPVVFRADWAARVSKADGVVYATGAAPKELAWQPIERAETIGSADENNIHCAARLNKSEIVVIGRRGGPAFLDSEIARLGHLTGLAMSIARAARAATP
>NC_008699.1|WP_041547027.1|272736_274041_-|MFS-transporter
MTATTPAPRSALAEPTTKPPGRWIAAITLASIGLWAGFFGPIQVLLAQQAEAIAPDDKKVVLSVVLGLGAFVSVVCNPVFGAFSDRTTLRAGRRLPWIAGGAVGGALSLLLLSVADNVVVMAIGWCGVQATLNAMLAAVTATVPDQVPVGERGRVGGILAVAQTVGVVGGTGIASATGSIAAGYVVTAGVLIVLTLPYCVGSRDVPLAPDELPPPFDWGGFLRSFWVSPRRHPDFAWAWITRFLVNLGNALGLLYLLYYLQDVIGVDKDEADDRVFLLTAIYAAVIMATTVVFGVWSDRTGKRKVFVIWSGVVGSLASLLLAVGQTWPAAVAAAVLMGVGYGIYTSVDFALITQVLPGAEDRAKDLGVINIANALPQVFAPFIAAVILLVVEAAGGVTETGGDRFSVGYCVLYSVAFLVAVLGSVFVTKIRSVP
>NC_008699.1|WP_011753752.1|274118_275576_-|alpha/beta-hydrolase
MRALTATLSLLLAGALAAPAAADPAPTDPAYTQRDAQNITDAYGRIDGEGGQLRNPAYLPALVAASTQRGVDQLLTQVASPTRPALTPGNVFPGWNVGNPLRAGWDGTRGVSRAVTFTNEYGAQLRGHVWKPLPGARDPYTGRRLHGPFPGVVITEGSVQGSEGMYEWLAQDLAERGYVVLTYDVQGQGTSETFPHQESPVPVDGLPFCNPFAAPDDGEMSGCPGVPSQQLSNFVVGTEAALDFITSRANPFRRSLDRSPDPHPATPGRTTRIAIIGHSMGAAAVSKVQGTDRRVAAVVALDKLAGPDSSGALDGAGNRPVVPALAVQSEYGFTVSPWFLSGGSSLSPQPSPDGPDPMRERATGYDAWRAAGVDAMLVVPRASTHLEYTDIPLVLPASRYGQDLTSVYVQRWLDRYLKHRDDTAALLADSFRYLEPAGDGVWSPVRLHRDDLLSFYYCSAYGLDTPRGEVADGDVTGVGCPSSIG
>NC_008699.1|WP_011753753.1|275611_276055_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MTLDGEYEPNPQQWVRDQVEEFEASNGQRANILMDHPEWPIVVITSRGATSGKLRKNPVMRVEKDGVYAAIASKGGTPEHPSWYHNFVAHPEVDLQDRSEKHSYRARIAEGAERAEWWERAVAQYAPYAEYQEKTDREIPVFLLERV
>NC_008699.1|WP_011753754.1|276110_277028_+|1,4-dihydroxy-2-naphthoyl-CoA-synthase
MSAIDGVSEIFDADAWDVVPGFEDLTDLTYHRAREHGTVRVAFDRPDVLNAFRPHTVDELLRVLEHARTSSDVGCVLLTGNGPSAKNGKWAFCTGGDQRIRGRAGYQYAEGETAETVDKAKLGRLHILEVQRLIRFMPKIVICVVPGWTAGGGHSLHVVCDLTLASAEEARFKQTDADVGSFDGGFGSAYLARQVGQKFAREIFFLGQEYSAEDGVRMGTVNRAVPHAELEATALEWGRIVNGKSPTAQRMLKYSFNAIDDGLVGQQLFAGETTRLAYMTDEAQEGRDQFLEKRDPDWSPFPWYY
>NC_008699.1|WP_041546072.1|277134_278469_+|hypothetical-protein
MSRAESLYTALVRRNPETEQEMPAQVRRSIAPNGLRQVLANALQSSGDQLVNASTVLPWLFGALGVPAALTGLLVPVRESGSMLPQAALTPLVLRARYRKRIFVAGALVQAVAVASMAAIAALGSGLAAGLVIVASLVVFALGRCLCSIASKDVQGRTIPKGERGQINGLATTAAGLVAITLGLAVRLLGGEDLSAGQLAGLLAAGAGLWVAVAVVYTGIREPADDPAGGAPARSPADDADTWFTRSLRLLKEDEHFRDFVGVRSLLLVSSLSPPFVVTLSTQAGAGGLAGLGGFIVASGVAALIGGRLFGRFADRSSRRLMSTGAGVASAVVIATVVVVAVPGSTGEGRSGNILFIGAYFLLTLMHTGVRVGRKTYVVDMAEGDRRTEYVAVSNSAMGLILLVVGGVSSALAIVHISWALLFLAGMGLVGVVAGARLPEVEHR
>NC_008699.1|WP_041546075.1|278930_280460_+|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-alpha
MRIGVPRESRAGETLVAATAQTASRLVKLGYDVVVESGAGGPASQPDEAYAEAGVTVSSAEEVWSSDVVVKINAPTDDEVARLGRGATVVSLMAPARSPELVERLAAAGVTALAMDAVPRISRAQSMDVLSSMANVAGYRAVVEAAHAFGRQFTGQVTAAGKIPPARVFVVGAGVAGLAAIGAAGSMGAIVRAFDVRPEVAEQVESMGAEFVTVDMQSEVSSDGYAKEMTAEQEKATAVMYDEEARAADIVITTALIPGRPAPRLIGEETVAGMRPGSVIVDMAAANGGNVAMTVADEEVVTDNGVRILGYTDLAGRLAAQTSQLYGTNVVNLLTLMTPEKDGALTLDLDDPVQRGLTVVREGEVLWPPPPVQVSAAPKAPAPTAPAEPPPPKKKRPMWLVFAAASVLLFLVATTAPAPLPEHFFVLTLAIVIGYYVIGHVHHALHTPLMSVTNAISGIIVVGAMLQLGVDDAAVRTLSFVAVLLASINVFGGFAVTRRMLGMFRKADQ

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Crispr_ID: NC_008699_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_6

297445-297530

Orphan

Consensus_repeat	Method
TTCCCCGGTTAACCGGGGATACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_6

>merge|NC_008699|6|297445-297530|CRISPRCasFinder
TTCCCCGGTTAACCGGGGATACCGGAACTGTTGGGCCGAAACTTCGGGCCAACAGTTCCAACTTCCCCGGTTAACCGGGGAAACCG

>NC_008699|6|6|297445-297530|CRISPRCasFinder
TTCCCCGGTTAACCGGGGATACCG	GAACTGTTGGGCCGAAACTTCGGGCCAACAGTTCCAAC
TTCCCCGGTTAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011753764.1\|287510_289760_-\|malto-oligosyltrehalose-synthase	unknown	unknown	gnl\|CDD\|237740
NC_008699.1\|WP_011753777.1\|302654_303251_+\|CocE/NonD-family-hydrolase	unknown	unknown	gnl\|CDD\|225487
NC_008699.1\|WP_011753773.1\|298808_299240_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NC_008699.1\|WP_049774189.1\|292122_293601_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
NC_008699.1\|WP_011753762.1\|285055_285760_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753776.1\|301390_302623_+\|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl\|CDD\|376451
NC_008699.1\|WP_083768248.1\|296356_297052_-\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232
NC_008699.1\|WP_158305619.1\|297248_297419_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753780.1\|304959_305166_-\|DUF1918-domain-containing-protein	unknown	unknown	gnl\|CDD\|378101
NC_008699.1\|WP_011753765.1\|289764_291966_-\|glycogen-debranching-protein-GlgX	unknown	unknown	gnl\|CDD\|131155
NC_008699.1\|WP_011753778.1\|303598_304468_+\|sulfotransferase	unknown	unknown	gnl\|CDD\|366246
NC_008699.1\|WP_011753775.1\|299701_301321_-\|FMN-binding-glutamate-synthase-family-protein	unknown	unknown	gnl\|CDD\|239202
NC_008699.1\|WP_011753772.1\|298299_298785_+\|tRNA-adenosine-deaminase-associated-protein	unknown	unknown	gnl\|CDD\|274869
NC_008699.1\|WP_011753767.1\|293626_294772_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173849
NC_008699.1\|WP_041547033.1\|304621_304891_+\|DUF1876-domain-containing-protein	unknown	unknown	gnl\|CDD\|378103
NC_008699.1\|WP_011753763.1\|285766_287506_-\|malto-oligosyltrehalose-trehalohydrolase	unknown	unknown	gnl\|CDD\|274114
NC_008699.1\|WP_011753768.1\|294847_295579_+\|VIT1/CCC1-transporter-family-protein	unknown	unknown	gnl\|CDD\|153123
NC_008699.1\|WP_011753769.1\|295783_296350_+\|RNA-2',3'-cyclic-phosphodiesterase	unknown	unknown	gnl\|CDD\|224431
NC_008699.1\|WP_041547030.1\|299302_299674_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319924
NC_008699.1\|WP_011753771.1\|297538_298180_-\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011753764.1\|287510_289760_-\|malto-oligosyltrehalose-synthase	gnl\|CDD\|237740	PRK14511, PRK14511, malto-oligosyltrehalose synthase.	0
NC_008699.1\|WP_011753777.1\|302654_303251_+\|CocE/NonD-family-hydrolase	gnl\|CDD\|225487	COG2936, COG2936, Predicted acyl esterases [General function prediction only].	6.91845e-21
NC_008699.1\|WP_011753773.1\|298808_299240_+\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	5.19998e-63
NC_008699.1\|WP_049774189.1\|292122_293601_+\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.28003e-57
NC_008699.1\|WP_083768248.1\|296356_297052_-\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	3.78481e-81
NC_008699.1\|WP_011753776.1\|301390_302623_+\|alpha-hydroxy-acid-oxidizing-protein	gnl\|CDD\|376451	pfam01070, FMN_dh, FMN-dependent dehydrogenase.	2.07646e-159
NC_008699.1\|WP_011753780.1\|304959_305166_-\|DUF1918-domain-containing-protein	gnl\|CDD\|378101	pfam08940, DUF1918, Domain of unknown function (DUF1918). This domain, found in various hypothetical bacterial proteins, has no known function.	5.07584e-28
NC_008699.1\|WP_011753765.1\|289764_291966_-\|glycogen-debranching-protein-GlgX	gnl\|CDD\|131155	TIGR02100, Glycogen_operon_protein_GlgX_homolog, glycogen debranching enzyme GlgX. This family consists of the GlgX protein from the E. coli glycogen operon and probable equivalogs from other prokaryotic species. GlgX is not required for glycogen biosynthesis, but instead acts as a debranching enzyme for glycogen catabolism. This model distinguishes GlgX from pullanases and other related proteins that also operate on alpha-1,6-glycosidic linkages. In the wide band between the trusted and noise cutoffs are functionally similar enzymes, mostly from plants, that act similarly but usually are termed isoamylase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_008699.1\|WP_011753778.1\|303598_304468_+\|sulfotransferase	gnl\|CDD\|366246	pfam00685, Sulfotransfer_1, Sulfotransferase domain.	2.89409e-07
NC_008699.1\|WP_011753775.1\|299701_301321_-\|FMN-binding-glutamate-synthase-family-protein	gnl\|CDD\|239202	cd02808, GltS_FMN, Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.	4.19627e-142
NC_008699.1\|WP_011753772.1\|298299_298785_+\|tRNA-adenosine-deaminase-associated-protein	gnl\|CDD\|274869	TIGR03941, conserved_hypothetical_protein, putative tRNA adenosine deaminase-associated protein. This model describes a protein family about 200 amino acids in length with only five invariant residues, including an Arg, a Ser-Asp pair, and two Gly residues. Members always are found exclusively in Actinobacteria, and always adjacent to homologs of TadA, a tRNA-specific adenosine deaminase from Escherichia coli. Homology, phyletic pattern, and gene neighborhood together suggest a housekeeping function in tRNA metabolism. [Unknown function, General].	3.76144e-46
NC_008699.1\|WP_011753767.1\|293626_294772_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	5.5342e-145
NC_008699.1\|WP_041547033.1\|304621_304891_+\|DUF1876-domain-containing-protein	gnl\|CDD\|378103	pfam08962, DUF1876, Domain of unknown function (DUF1876). This domain is found in a set of hypothetical bacterial proteins.	6.86435e-34
NC_008699.1\|WP_011753763.1\|285766_287506_-\|malto-oligosyltrehalose-trehalohydrolase	gnl\|CDD\|274114	TIGR02402, Malto-oligosyltrehalose_trehalohydrolase, malto-oligosyltrehalose trehalohydrolase. Members of this family are the trehalose biosynthetic enzyme malto-oligosyltrehalose trehalohydrolase, formally known as 4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase (EC 3.2.1.141). It is the TreZ protein of the TreYZ pathway for trehalose biosynthesis, and alternative to the OtsAB system. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_008699.1\|WP_011753768.1\|294847_295579_+\|VIT1/CCC1-transporter-family-protein	gnl\|CDD\|153123	cd02432, Nodulin-21_like_1, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	7.29848e-90
NC_008699.1\|WP_011753769.1\|295783_296350_+\|RNA-2',3'-cyclic-phosphodiesterase	gnl\|CDD\|224431	COG1514, LigT, 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis].	8.78885e-38
NC_008699.1\|WP_041547030.1\|299302_299674_+\|VOC-family-protein	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	6.97049e-22
NC_008699.1\|WP_011753771.1\|297538_298180_-\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	1.26182e-119

>NC_008699.1|WP_158305619.1|297248_297419_+|hypothetical-protein
MTDDDERLGRPDGHRYDAPESEETRAGKEWVYAVLGVLVLVLLILIATGKVQIFPS
>NC_008699.1|WP_083768248.1|296356_297052_-|GTP-pyrophosphokinase-family-protein
MLEHRFGMDEIVTKLTILRDEFTHLRDYNPIESVSSRLKSPESLVEKMLRKGLVLDERPSFDQIRATVTDIAGVRVVCSFVSDVYRVFDMLVEQEDVSTVEVRDYIATPKPNGYRSLHALVEVPVFLSEGPVPVLVEVQFRTIAMDFWASLEHKIYYKYRREVPAELLERLHDAAETAYALDATMERLHEEVRGLDELPPDVLAQLRDGGERPDAALREALRKLGATPETA
>NC_008699.1|WP_011753769.1|295783_296350_+|RNA-2',3'-cyclic-phosphodiesterase
MRMFVALVPPAEAVEHLDAFLEPRRSAAAFRWAGVEQLHVTVAFLAEVEERRLEDLVERLGRAAARRSAFDTAITGGGAFPNVGRARVLWAGLALDEHGRTQLDRLATGCRTAANRAGVPVDGQRFRPHLTVARIAHPTEATSWVRLLDGYAGPAWRADRVELVASYLGEGPRGRPRYETVAELELAG
>NC_008699.1|WP_011753768.1|294847_295579_+|VIT1/CCC1-transporter-family-protein
MTTSEIEVPAGPHESEPHIRGFNNRLNWLRAAVLGANDGIVSTAGIVIGAIGATSDRNAIVIAGVAGLAAGAMSMAAGEYVSVSTQRDSELALLEKERRELLEEPEEELAELAGLYAAKGLPDDLALEVATVLTAQDALAAHAEVELGIDPDDIASPLHAAWASMLAFTIGALLPLLSITLASAETRVPLTVGVVVLALAITGWASARLGYSSPARAVARNVAGGLFAMAVTFAIGSALGTQI
>NC_008699.1|WP_011753767.1|293626_294772_+|acyl-CoA-dehydrogenase-family-protein
MKRSIYDDDHEAFRDSVREFLERSVIPQVEQHAADKAIPRDFWTEAGRQGFLGLEIPEEYGGAEAGDYRFNAVLLEELNKVNAALGSCVGIHADITAPYLVELGTDEQKQRWLPGVAAGEVLLAIGMTEPSGGSDLAALKTTAVKDGDSWVINGSKTFITNGYSADLVLVAARTSPEKKARGITLFAVESTAPGYSRGRKLDKIGQDESDTAELFFENVRVTDAEIVGELDGGFIHMMQKLPQERLGCAISNVAHAKQILLETLQYAKDRKAFGQGIGSFQYNKFLLAELFTRIEVTEAFIDQCVVAHAAGELTPIDAAKAKWWSSQVQNEVLDHCVQLHGGYGYMNEYRVARAWRDARVSKIWAGSNEIMKELIGRDLGL
>NC_008699.1|WP_049774189.1|292122_293601_+|MFS-transporter
MSATGWALLSDVALSDVSRASVGLRSERGPVLLAVMLSNGLVAIDSTILATAVPAVVTDLGGFTQFPWLFSVYLLAQAVSVPIYAKLADLYGRKPMLLLGIGLFVLGSLLCGLAWGMGALIAFRALQGLGAGAVQPIGLTVVGDIYSIQERAKVQGYLASVWAISAIVGPTLGGAFSDYLSWRWIFFVNLPLGVAAAWMFWRRFDERVERRRHRIDHAGAVLLAGGGLLLMLALLEGGVRWPWSSVTSVALFSGAAVLLVGFVLVERRAAEPILPLWVFRHRVLGSAMSASLIVGVLVMGLASYVPLYAQAVLGHGAVVAGFALAGMTLGWPLASSSAGRLFLTIGPRSTMMLGGATTAAGAALLLTVGADSSFLHLAVPCFVMGLGFGLVASPAVIAAQSAVTWQDRGVATGSTMFARSMGSAIGVAVFGAVANGVVASRLGSRAGSLELVTPRVLEPAIGAVFLTSAVVALSLVAISAVMTRRIAEPVTD
>NC_008699.1|WP_011753765.1|289764_291966_-|glycogen-debranching-protein-GlgX
MQVWPGRAYPLGATFDGSGTNFALFSEVADRVELCLFDAEGSEGYRETRVELTEVDAYVWHCYLPAVQPGQRYGYRVHGPWDPENGQRCNPNKLLLDPYAKATSGEIDWDQSLFSYNFGDPEDSDARNDEDSAPHMTHGVVINPFFDWEGDRRLDYDYNESIIYEAHVKGLTQLHPDIPEELRGTYAALGHPAITEHLTKLGVTAIELMPVHQFIQDSTLLDKGLRNYWGYNTLGFFAPHADYAATGQPGQQVQEFKSMVKAMHAAGIEVILDVVYNHTAEGNHLGPTLSFKGIDNAAYYRLVEDDQRYYMDYTGTGNSLNVRHPHSLQLLMDSLRYWVTEMHVDGFRFDLASTLAREFYDVDRLSTFFELVQQDPVVSQVKLIAEPWDIGPGGYQVGGFPPQWTEWNGKYRDTVRDFWRGEPSLGEFASRLAGSADLYEHSGRRPVASINFVTAHDGFTLRDLVSYDEKHNEANGEDNNDGESHNRSWNHGVEGPTDDPEILEFRAREQRNFIATLLLSQGVPMLLHGDEMGRTQQGNNNTYAQDSELSWVHWDEADKPLVEFTAALSRLRRAHPTFRRKRFFTGGTVRVPDGGDGDRLNDIVWLHLDGRPMEDNDWTQSDSGAGAQALGMYLNGHGIAGRDERGGPIVDNHFLLYFNADGPAEVTLPPDEYADAWDVVVDTGGLVDDQTALAAGSTCSMASRSLIVLREHREPEAEVDHSVAASVAQARRG
>NC_008699.1|WP_011753764.1|287510_289760_-|malto-oligosyltrehalose-synthase
MRAPVSTYRLQITPEFDLFEAARRLPYLRALGADWVYLSPLLASEPGSNHGYDVVAFDRVDPARGGAEGLAVLSAEARRLGMGILVDIVPNHVGVATPAENAWWWDLLQHGRASKHADAFDVDWDAGDGKVLIPVVGDGDGGSIRVEDGEVRYHDHRFPLAAGTSAHEEQHYRLVSWRDADDKLNYRRFFAVNTLAGVRVEEPEVFAQSHVEIRRWFAEGLVDGLRVDHPDGLRDPQGYLDDLADLTGRAYVLVEKILEPGEKLPRSWATQGTTGYDGLALVDRVLTDPTGQAPLDRLEARLRGAPVDWPDLIHGTKRAVADGILQSEVRRIVREIGPEDPAPYRDAVAELLTCFPVYRSYLPEGRDHLAEAFARARRTRPDLAATYDALEPVLTDAASPPALRFQQTSGMVMAKGVEDCAFYRWSRLTSLTEVGGDPSVFAVTVAGFHEAMAARQRDWPHTMNTLSTHDTKRGEDVRARITALAEMPDTWAAALERLLALAPVPDPGFGSLLWQAVLGAWTPEHLPDLRDRLHGYAEKAMREAGDRTTWTEPDATYEAAVHAAVDAAFDSTDVRAVLADLAARIDAPGRSNSLAAKLVAITMPGVPDVYQGSELFETSLVDPDNRRPVDFDHRAAVLAGTDADDAVDKLHVTCSALTLRRDRPELFTTYAAVPATGTAADHVLAFDRGGAISVATRLPVGLAARGGWGDTVLELPAGRWHDVLTGSSTEGRLADLLAALPVAMLVRAD
>NC_008699.1|WP_011753763.1|285766_287506_-|malto-oligosyltrehalose-trehalohydrolase
MTHGPFDVWAPLPRRLRLAVAGETVAMRRGEGDWWTPAGPVPAGAELDYGYLVDDGEAPRPDPRSRRQPGGVHQLSRTFDPASYPWTDQAWTGRQLAGSVVYELHVGTFTPEGTFDAALEKLPHLREIGVDLVELMPVNAFNGTHNWGYDGVGWFAVHEGYGGPAGYQRFVDGCHAAGLGVIQDVVYNHLGPSGNYLPELGPYLKQGANTWGDFLNLDGPGSDEVRRYILDNVRMWLADYHVDGLRLDAVHALNDAGHQHLLEELAAEVAALSAHQRRPLTLIAESDLNDTRLVRPREAGGYGLDAQWSDDFHHAVHVALTGETAGYYADFEPLSALAKVCERGFFHDGTWSSFRGRDHGFPVDLRTMPTWRLVVCSQNHDQIGNRARGDRITEVLDDDQLACAALLTLCGPFTPMLFMGEEWAASTPFQFFTSHPEPDLGTATAEGRIAEFERMGWDPAVVPDPQDPATFERSKLDWAEATRGRHARMLDVYRRLARLRREHEALTDPSFGSVRCTADEHTRVFTMRRGDLLVAVNFGDAAATVETAAATLLFQTGAGLTLDAGRLSLPPHAGALVGP
>NC_008699.1|WP_011753762.1|285055_285760_+|hypothetical-protein
MARIAMAAVGLGTAALLTACGGGDDFTDQSADDIVSAAKSEMGDLKAVKVSGSVTSDGQQIDIDLQSSSEGSCTGTIGVAGGTTELLGVDGSTWMKPDEAFWRATAGDAADSVITAVGDKWVVIPAEDDSFNTFCDLDDLLDQLLKDDEEDGSTYSKNGTEDVDGETAVKVDNEDPEDGTSTGYVLVDEPHYLVKIEKTDGADTGNITFSEFDEEFDVEAPGADEVVDLDQLGA
>NC_008699.1|WP_011753771.1|297538_298180_-|uracil-phosphoribosyltransferase
MRTHVVDHPLVAHKLTHLRNEETDSPTFRRLADELVTLLAYEATRDVRVEPIDVVTPVSPTTGVQLAKPRPLVVPILRAGLGMLDGMMRLLPTAEVGFLGMIRNEETLQASTYAERLPEDLSGRQCYVLDPMLATGGTLAAAIRFLTDRGADHITAICLLAAPEGCARLEQELDGLDVPVTIVTAAMDERLNEKGYIVPGLGDAGDRLYGIVG
>NC_008699.1|WP_011753772.1|298299_298785_+|tRNA-adenosine-deaminase-associated-protein
MADQVDGIDFALAAYREGGAWTVQELAHDVLEDIDTLSAALRRFPGDGGAVGMVAIEEDFFVVVRVAGPTTRVLLSDITAADEWELASSAVEFLGLPLPEDEDDPVPAGDLDLLGDLGMHAMDMGVLLDDIDLYPDEMLSDVARRLGFGKLFDDAVGLTSA
>NC_008699.1|WP_011753773.1|298808_299240_+|nucleoside-deaminase
MRTALDEARAALASGDVPIGAVVLDPDGTPVARGRNVREADHDPTGHAEVVALRAAARARGEWRLEGHTLVVTLEPCTMCAGAAVLSRVERIVFGAWDPKAGAVGSLWDVVRDRRLNHRPEVISGVLAEESAGLLEDFFLTQR
>NC_008699.1|WP_041547030.1|299302_299674_+|VOC-family-protein
MDYKIELIPLAVRDVDRSIAFYGDSLGWSVDHDQTVSPTLRFVQVTPPGSACSICFGVGLEMMPAGSSQFIQVVVADADAALAELRERGVGCEGVDDQPWGRFVYFQDPDGNRWALQQVVRPS
>NC_008699.1|WP_011753775.1|299701_301321_-|FMN-binding-glutamate-synthase-family-protein
MRKTTLAALPAAALGAVAAHDLLQRRHAILRNFPVVGHARYWLEALGPELRQYIVASNDEERPFSRDQRRWVYASAKLQNNYFGFGTDNDLEHSSGNVIVHHRTFGRSYPTHGAVGQEARLPSAKILGGPRGRRRAFRPASVVNVSGMSFGSLSGNAVEAINRGAAEAGCLHNTGEGAVSPYHRQGADLVFQIGTAYFGCRDDDGRFSLPRLKDLVESAPVRALEIKLSQGAKPGLGGVLPAAKVSAEIAATRGVPAGLDCLSPSRHAEFDDVDSLLDFVELLADETGLPVGIKSAVGDLGFWRDLTEEMAKGQRGVDFVTIDGGEGGTGASPLIFTDAVSLPFRLGFARVYAEFARRGLHEDVTFIGSGKLGLPDNAVVAFALGADLVNVAREAMLAVGCIQAQKCHTGECPTGVATQNPWLAHGLDPVEKSGRVANYVRTLRRDLLKVAETCGVEHPGLIGPHDVEILDNLSDGRLLDEVYGYDPGWGFPSARDRQEIAAIMSATEEPETRTEGPPETAEEGAPGTEHAGDEEPSGD
>NC_008699.1|WP_011753776.1|301390_302623_+|alpha-hydroxy-acid-oxidizing-protein
MKRQLPRRRDLAPLVRFRTPVLSPRGRRLRDALTIEDLRRAARRRTPRAAFDYTDGAADDEISLARARQAFRDVQFNPGVLRDVSSVDTSREVLGARASLPFGIAPTGFTRLMHTEGEVAGATAAAAAGIPFALSTMGTTSIEDVAAAAPSGRHWFQLYMWKDRDRSMALVERAARAGFDALLVTVDVPVAGARLRDVRNGMTIPPTLTPRTVLDAIPRMRWWFDLLTTEPLAFATLDSWSGTVAELLDTMFDPTVTFEDLAWIKEQWPGRLVVKGIQTVDDARRVADLGADAVLLSNHGGRQLDRAPIPFRLLPEVVAAVGQDVEVHLDTGIMSGQDIVAALAHGARFTLVGRAYLYGLMAGGRDGVDRAVEILRSQVERTMRLLGVRSLGDLEPGHVTQLDRLEPRRR
>NC_008699.1|WP_011753777.1|302654_303251_+|CocE/NonD-family-hydrolase
MNRYAAALVVALSALVAPPAHAASAHATSAAQEAWSPRPEIYPATVTRTDLAVPMSDGVVLRGDLVLPAGADGRAVRGRFPVIVTITAYNKTALSSGGGVAGAPPAYLVQRGYAQLTVDARGTGSSEGQWSAFGARENEDSAEVVEWAHSRKRPWSDGRVGMSGPITARLYTSSVSGDGMLSVSVSDVAPDGTVSRLS
>NC_008699.1|WP_011753778.1|303598_304468_+|sulfotransferase
MTRIPLEEAPRIPINVAIAGVQKAGTSSLFDLLRKHPEVCAGPRKEWHFFDDEKRSWADPDYSDYWAPGRTDRQRIAIDGTPAYTFWPHAMERMHAYRPDMRLIVSLRDPIERAFSHWAMYYGKLPAFPSFSQLAQGPRREGLLERIPEGWNHLRMRRWSMIPRGLYGAQVARGLELFSREQWLFLDFHRFVGEHRETLDRVTSFLGLDPYPKEPRLRVIQSTRQDLVAAAPTAADVSRLVEVYADDLDLLTRLTGLDVSDWPTRRVRDGLLDPADLADRLGRKAGLLG
>NC_008699.1|WP_041547033.1|304621_304891_+|DUF1876-domain-containing-protein
MHTKTWSVEIFIGEHDGQTRAEARLATEPSATRLTGWGIARLNPADPEVPEIGDELATARALADLAHQLLETAAVDIGAVTSKPVHLTH
>NC_008699.1|WP_011753780.1|304959_305166_-|DUF1918-domain-containing-protein
MHATKGDHLVIHGTHVGEPLRDGEIVEVRGPDGAPPYVVRWADNGHESLTYPGPDAEVHHLHHKGEGG

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Crispr_ID: NC_008699_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_5

295604-295702

Orphan

Consensus_repeat	Method
CGCCCACGGGGCTGACCGTCCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_5

>merge|NC_008699|5|295604-295702|CRISPRCasFinder
CGCCCACGGGGCTGACCGTCCGACGGCGTGGCCGCGTCTGGCGCGTCGCCTTCGGCGCCACGCCGGCCGCGGGATCGCCCACGGGGTTGACCGTCCGAC

>NC_008699|5|5|295604-295702|CRISPRCasFinder
CGCCCACGGGGCTGACCGTCCGAC	GGCGTGGCCGCGTCTGGCGCGTCGCCTTCGGCGCCACGCCGGCCGCGGGAT
CGCCCACGGGGTTGACCGTCCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011753764.1\|287510_289760_-\|malto-oligosyltrehalose-synthase	unknown	unknown	gnl\|CDD\|237740
NC_008699.1\|WP_011753777.1\|302654_303251_+\|CocE/NonD-family-hydrolase	unknown	unknown	gnl\|CDD\|225487
NC_008699.1\|WP_158305619.1\|297248_297419_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753760.1\|283043_284195_+\|DUF697-domain-containing-protein	unknown	unknown	gnl\|CDD\|226125
NC_008699.1\|WP_011753762.1\|285055_285760_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753776.1\|301390_302623_+\|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl\|CDD\|376451
NC_008699.1\|WP_083768248.1\|296356_297052_-\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232
NC_008699.1\|WP_049774189.1\|292122_293601_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
NC_008699.1\|WP_011753759.1\|282484_282982_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753765.1\|289764_291966_-\|glycogen-debranching-protein-GlgX	unknown	unknown	gnl\|CDD\|131155
NC_008699.1\|WP_011753773.1\|298808_299240_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NC_008699.1\|WP_011753775.1\|299701_301321_-\|FMN-binding-glutamate-synthase-family-protein	unknown	unknown	gnl\|CDD\|239202
NC_008699.1\|WP_011753772.1\|298299_298785_+\|tRNA-adenosine-deaminase-associated-protein	unknown	unknown	gnl\|CDD\|274869
NC_008699.1\|WP_011753767.1\|293626_294772_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173849
NC_008699.1\|WP_011753763.1\|285766_287506_-\|malto-oligosyltrehalose-trehalohydrolase	unknown	unknown	gnl\|CDD\|274114
NC_008699.1\|WP_011753768.1\|294847_295579_+\|VIT1/CCC1-transporter-family-protein	unknown	unknown	gnl\|CDD\|153123
NC_008699.1\|WP_011753769.1\|295783_296350_+\|RNA-2',3'-cyclic-phosphodiesterase	unknown	unknown	gnl\|CDD\|224431
NC_008699.1\|WP_011753771.1\|297538_298180_-\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
NC_008699.1\|WP_041547030.1\|299302_299674_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319924
NC_008699.1\|WP_011753761.1\|284214_284913_+\|NAD-dependent-deacylase	unknown	unknown	gnl\|CDD\|234777

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011753764.1\|287510_289760_-\|malto-oligosyltrehalose-synthase	gnl\|CDD\|237740	PRK14511, PRK14511, malto-oligosyltrehalose synthase.	0
NC_008699.1\|WP_011753777.1\|302654_303251_+\|CocE/NonD-family-hydrolase	gnl\|CDD\|225487	COG2936, COG2936, Predicted acyl esterases [General function prediction only].	6.91845e-21
NC_008699.1\|WP_011753773.1\|298808_299240_+\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	5.19998e-63
NC_008699.1\|WP_011753760.1\|283043_284195_+\|DUF697-domain-containing-protein	gnl\|CDD\|226125	COG3597, COG3597, Uncharacterized protein/domain associated with GTPases [Function unknown].	5.41196e-19
NC_008699.1\|WP_049774189.1\|292122_293601_+\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.28003e-57
NC_008699.1\|WP_083768248.1\|296356_297052_-\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	3.78481e-81
NC_008699.1\|WP_011753776.1\|301390_302623_+\|alpha-hydroxy-acid-oxidizing-protein	gnl\|CDD\|376451	pfam01070, FMN_dh, FMN-dependent dehydrogenase.	2.07646e-159
NC_008699.1\|WP_011753765.1\|289764_291966_-\|glycogen-debranching-protein-GlgX	gnl\|CDD\|131155	TIGR02100, Glycogen_operon_protein_GlgX_homolog, glycogen debranching enzyme GlgX. This family consists of the GlgX protein from the E. coli glycogen operon and probable equivalogs from other prokaryotic species. GlgX is not required for glycogen biosynthesis, but instead acts as a debranching enzyme for glycogen catabolism. This model distinguishes GlgX from pullanases and other related proteins that also operate on alpha-1,6-glycosidic linkages. In the wide band between the trusted and noise cutoffs are functionally similar enzymes, mostly from plants, that act similarly but usually are termed isoamylase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_008699.1\|WP_011753761.1\|284214_284913_+\|NAD-dependent-deacylase	gnl\|CDD\|234777	PRK00481, PRK00481, NAD-dependent deacetylase; Provisional.	1.3374e-118
NC_008699.1\|WP_011753775.1\|299701_301321_-\|FMN-binding-glutamate-synthase-family-protein	gnl\|CDD\|239202	cd02808, GltS_FMN, Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.	4.19627e-142
NC_008699.1\|WP_011753772.1\|298299_298785_+\|tRNA-adenosine-deaminase-associated-protein	gnl\|CDD\|274869	TIGR03941, conserved_hypothetical_protein, putative tRNA adenosine deaminase-associated protein. This model describes a protein family about 200 amino acids in length with only five invariant residues, including an Arg, a Ser-Asp pair, and two Gly residues. Members always are found exclusively in Actinobacteria, and always adjacent to homologs of TadA, a tRNA-specific adenosine deaminase from Escherichia coli. Homology, phyletic pattern, and gene neighborhood together suggest a housekeeping function in tRNA metabolism. [Unknown function, General].	3.76144e-46
NC_008699.1\|WP_011753767.1\|293626_294772_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	5.5342e-145
NC_008699.1\|WP_011753763.1\|285766_287506_-\|malto-oligosyltrehalose-trehalohydrolase	gnl\|CDD\|274114	TIGR02402, Malto-oligosyltrehalose_trehalohydrolase, malto-oligosyltrehalose trehalohydrolase. Members of this family are the trehalose biosynthetic enzyme malto-oligosyltrehalose trehalohydrolase, formally known as 4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase (EC 3.2.1.141). It is the TreZ protein of the TreYZ pathway for trehalose biosynthesis, and alternative to the OtsAB system. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_008699.1\|WP_011753768.1\|294847_295579_+\|VIT1/CCC1-transporter-family-protein	gnl\|CDD\|153123	cd02432, Nodulin-21_like_1, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	7.29848e-90
NC_008699.1\|WP_011753769.1\|295783_296350_+\|RNA-2',3'-cyclic-phosphodiesterase	gnl\|CDD\|224431	COG1514, LigT, 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis].	8.78885e-38
NC_008699.1\|WP_041547030.1\|299302_299674_+\|VOC-family-protein	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	6.97049e-22
NC_008699.1\|WP_011753771.1\|297538_298180_-\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	1.26182e-119

>NC_008699.1|WP_011753768.1|294847_295579_+|VIT1/CCC1-transporter-family-protein
MTTSEIEVPAGPHESEPHIRGFNNRLNWLRAAVLGANDGIVSTAGIVIGAIGATSDRNAIVIAGVAGLAAGAMSMAAGEYVSVSTQRDSELALLEKERRELLEEPEEELAELAGLYAAKGLPDDLALEVATVLTAQDALAAHAEVELGIDPDDIASPLHAAWASMLAFTIGALLPLLSITLASAETRVPLTVGVVVLALAITGWASARLGYSSPARAVARNVAGGLFAMAVTFAIGSALGTQI
>NC_008699.1|WP_011753767.1|293626_294772_+|acyl-CoA-dehydrogenase-family-protein
MKRSIYDDDHEAFRDSVREFLERSVIPQVEQHAADKAIPRDFWTEAGRQGFLGLEIPEEYGGAEAGDYRFNAVLLEELNKVNAALGSCVGIHADITAPYLVELGTDEQKQRWLPGVAAGEVLLAIGMTEPSGGSDLAALKTTAVKDGDSWVINGSKTFITNGYSADLVLVAARTSPEKKARGITLFAVESTAPGYSRGRKLDKIGQDESDTAELFFENVRVTDAEIVGELDGGFIHMMQKLPQERLGCAISNVAHAKQILLETLQYAKDRKAFGQGIGSFQYNKFLLAELFTRIEVTEAFIDQCVVAHAAGELTPIDAAKAKWWSSQVQNEVLDHCVQLHGGYGYMNEYRVARAWRDARVSKIWAGSNEIMKELIGRDLGL
>NC_008699.1|WP_049774189.1|292122_293601_+|MFS-transporter
MSATGWALLSDVALSDVSRASVGLRSERGPVLLAVMLSNGLVAIDSTILATAVPAVVTDLGGFTQFPWLFSVYLLAQAVSVPIYAKLADLYGRKPMLLLGIGLFVLGSLLCGLAWGMGALIAFRALQGLGAGAVQPIGLTVVGDIYSIQERAKVQGYLASVWAISAIVGPTLGGAFSDYLSWRWIFFVNLPLGVAAAWMFWRRFDERVERRRHRIDHAGAVLLAGGGLLLMLALLEGGVRWPWSSVTSVALFSGAAVLLVGFVLVERRAAEPILPLWVFRHRVLGSAMSASLIVGVLVMGLASYVPLYAQAVLGHGAVVAGFALAGMTLGWPLASSSAGRLFLTIGPRSTMMLGGATTAAGAALLLTVGADSSFLHLAVPCFVMGLGFGLVASPAVIAAQSAVTWQDRGVATGSTMFARSMGSAIGVAVFGAVANGVVASRLGSRAGSLELVTPRVLEPAIGAVFLTSAVVALSLVAISAVMTRRIAEPVTD
>NC_008699.1|WP_011753765.1|289764_291966_-|glycogen-debranching-protein-GlgX
MQVWPGRAYPLGATFDGSGTNFALFSEVADRVELCLFDAEGSEGYRETRVELTEVDAYVWHCYLPAVQPGQRYGYRVHGPWDPENGQRCNPNKLLLDPYAKATSGEIDWDQSLFSYNFGDPEDSDARNDEDSAPHMTHGVVINPFFDWEGDRRLDYDYNESIIYEAHVKGLTQLHPDIPEELRGTYAALGHPAITEHLTKLGVTAIELMPVHQFIQDSTLLDKGLRNYWGYNTLGFFAPHADYAATGQPGQQVQEFKSMVKAMHAAGIEVILDVVYNHTAEGNHLGPTLSFKGIDNAAYYRLVEDDQRYYMDYTGTGNSLNVRHPHSLQLLMDSLRYWVTEMHVDGFRFDLASTLAREFYDVDRLSTFFELVQQDPVVSQVKLIAEPWDIGPGGYQVGGFPPQWTEWNGKYRDTVRDFWRGEPSLGEFASRLAGSADLYEHSGRRPVASINFVTAHDGFTLRDLVSYDEKHNEANGEDNNDGESHNRSWNHGVEGPTDDPEILEFRAREQRNFIATLLLSQGVPMLLHGDEMGRTQQGNNNTYAQDSELSWVHWDEADKPLVEFTAALSRLRRAHPTFRRKRFFTGGTVRVPDGGDGDRLNDIVWLHLDGRPMEDNDWTQSDSGAGAQALGMYLNGHGIAGRDERGGPIVDNHFLLYFNADGPAEVTLPPDEYADAWDVVVDTGGLVDDQTALAAGSTCSMASRSLIVLREHREPEAEVDHSVAASVAQARRG
>NC_008699.1|WP_011753764.1|287510_289760_-|malto-oligosyltrehalose-synthase
MRAPVSTYRLQITPEFDLFEAARRLPYLRALGADWVYLSPLLASEPGSNHGYDVVAFDRVDPARGGAEGLAVLSAEARRLGMGILVDIVPNHVGVATPAENAWWWDLLQHGRASKHADAFDVDWDAGDGKVLIPVVGDGDGGSIRVEDGEVRYHDHRFPLAAGTSAHEEQHYRLVSWRDADDKLNYRRFFAVNTLAGVRVEEPEVFAQSHVEIRRWFAEGLVDGLRVDHPDGLRDPQGYLDDLADLTGRAYVLVEKILEPGEKLPRSWATQGTTGYDGLALVDRVLTDPTGQAPLDRLEARLRGAPVDWPDLIHGTKRAVADGILQSEVRRIVREIGPEDPAPYRDAVAELLTCFPVYRSYLPEGRDHLAEAFARARRTRPDLAATYDALEPVLTDAASPPALRFQQTSGMVMAKGVEDCAFYRWSRLTSLTEVGGDPSVFAVTVAGFHEAMAARQRDWPHTMNTLSTHDTKRGEDVRARITALAEMPDTWAAALERLLALAPVPDPGFGSLLWQAVLGAWTPEHLPDLRDRLHGYAEKAMREAGDRTTWTEPDATYEAAVHAAVDAAFDSTDVRAVLADLAARIDAPGRSNSLAAKLVAITMPGVPDVYQGSELFETSLVDPDNRRPVDFDHRAAVLAGTDADDAVDKLHVTCSALTLRRDRPELFTTYAAVPATGTAADHVLAFDRGGAISVATRLPVGLAARGGWGDTVLELPAGRWHDVLTGSSTEGRLADLLAALPVAMLVRAD
>NC_008699.1|WP_011753763.1|285766_287506_-|malto-oligosyltrehalose-trehalohydrolase
MTHGPFDVWAPLPRRLRLAVAGETVAMRRGEGDWWTPAGPVPAGAELDYGYLVDDGEAPRPDPRSRRQPGGVHQLSRTFDPASYPWTDQAWTGRQLAGSVVYELHVGTFTPEGTFDAALEKLPHLREIGVDLVELMPVNAFNGTHNWGYDGVGWFAVHEGYGGPAGYQRFVDGCHAAGLGVIQDVVYNHLGPSGNYLPELGPYLKQGANTWGDFLNLDGPGSDEVRRYILDNVRMWLADYHVDGLRLDAVHALNDAGHQHLLEELAAEVAALSAHQRRPLTLIAESDLNDTRLVRPREAGGYGLDAQWSDDFHHAVHVALTGETAGYYADFEPLSALAKVCERGFFHDGTWSSFRGRDHGFPVDLRTMPTWRLVVCSQNHDQIGNRARGDRITEVLDDDQLACAALLTLCGPFTPMLFMGEEWAASTPFQFFTSHPEPDLGTATAEGRIAEFERMGWDPAVVPDPQDPATFERSKLDWAEATRGRHARMLDVYRRLARLRREHEALTDPSFGSVRCTADEHTRVFTMRRGDLLVAVNFGDAAATVETAAATLLFQTGAGLTLDAGRLSLPPHAGALVGP
>NC_008699.1|WP_011753762.1|285055_285760_+|hypothetical-protein
MARIAMAAVGLGTAALLTACGGGDDFTDQSADDIVSAAKSEMGDLKAVKVSGSVTSDGQQIDIDLQSSSEGSCTGTIGVAGGTTELLGVDGSTWMKPDEAFWRATAGDAADSVITAVGDKWVVIPAEDDSFNTFCDLDDLLDQLLKDDEEDGSTYSKNGTEDVDGETAVKVDNEDPEDGTSTGYVLVDEPHYLVKIEKTDGADTGNITFSEFDEEFDVEAPGADEVVDLDQLGA
>NC_008699.1|WP_011753761.1|284214_284913_+|NAD-dependent-deacylase
MVVRIVVLTGAGISAESGLPTFRDADGLWHGHRVEEVATPEAFERVPALVHRFYDERRAALATVRPNAAHEALARLEQALGDDLLVVTQNIDDLHERSGSRQVLHMHGRLRSALCGSCAGHFDWVGDLGDAPPCPRCGRRELRPDVVWFGEAPYDMDRILGAVGRADLFVSVGTSGAVYPAAGFVQYAAGQGARTLELNLVPSEGSHLFDESRHGPASRLVPEWVAEIFDTP
>NC_008699.1|WP_011753760.1|283043_284195_+|DUF697-domain-containing-protein
MGTPADDWFGQAFSKAWRDKAEEIGRFNLAIFGKTGVGKSTLVNAIFGSEIAATGIGEPVTRAEHLYLHQSGTLGVLDTRGLEVGRDNDALIAELKDYLHGMRRRPLADQLHVAWYCVRAGDRRFEATEAEFVRALHELGLPVILVLTQVPRSIGPGGDARVHPDAEALAASIAELRLPIVDGLIHYTMALEDDFTGQAAYGLQELLDATFRGAPEGVAHAITAAQRIDFVRKRERAEKAIKAATGAATTAGASPIPFSDAAILVPLQIGMMASIAVTYGVPLERSTAASLAATAAATTAGRSLVTNLVKFVPGAGTMVAAPISATVAGTFTYAMGQAWLRVCERLARGELGVVGGALDGESVRKVFLEEFKTQAARRRVGRR
>NC_008699.1|WP_011753759.1|282484_282982_+|hypothetical-protein
MAAYGDRLLIGAGSDGGRLTVFEKVGDGPFRVLARSRAVHDFDVAYSGREPVLAWSRGRLRQLSLVVGGRLVNTRTPTEAVALATDGRLVHVVFSTVARTTCGPAGCLHSGVYHVGLRGRRVAIKASLVQAGSSSPFRLAADTSGRTLGVVVSRNGVTRLYQRSF
>NC_008699.1|WP_011753769.1|295783_296350_+|RNA-2',3'-cyclic-phosphodiesterase
MRMFVALVPPAEAVEHLDAFLEPRRSAAAFRWAGVEQLHVTVAFLAEVEERRLEDLVERLGRAAARRSAFDTAITGGGAFPNVGRARVLWAGLALDEHGRTQLDRLATGCRTAANRAGVPVDGQRFRPHLTVARIAHPTEATSWVRLLDGYAGPAWRADRVELVASYLGEGPRGRPRYETVAELELAG
>NC_008699.1|WP_083768248.1|296356_297052_-|GTP-pyrophosphokinase-family-protein
MLEHRFGMDEIVTKLTILRDEFTHLRDYNPIESVSSRLKSPESLVEKMLRKGLVLDERPSFDQIRATVTDIAGVRVVCSFVSDVYRVFDMLVEQEDVSTVEVRDYIATPKPNGYRSLHALVEVPVFLSEGPVPVLVEVQFRTIAMDFWASLEHKIYYKYRREVPAELLERLHDAAETAYALDATMERLHEEVRGLDELPPDVLAQLRDGGERPDAALREALRKLGATPETA
>NC_008699.1|WP_158305619.1|297248_297419_+|hypothetical-protein
MTDDDERLGRPDGHRYDAPESEETRAGKEWVYAVLGVLVLVLLILIATGKVQIFPS
>NC_008699.1|WP_011753771.1|297538_298180_-|uracil-phosphoribosyltransferase
MRTHVVDHPLVAHKLTHLRNEETDSPTFRRLADELVTLLAYEATRDVRVEPIDVVTPVSPTTGVQLAKPRPLVVPILRAGLGMLDGMMRLLPTAEVGFLGMIRNEETLQASTYAERLPEDLSGRQCYVLDPMLATGGTLAAAIRFLTDRGADHITAICLLAAPEGCARLEQELDGLDVPVTIVTAAMDERLNEKGYIVPGLGDAGDRLYGIVG
>NC_008699.1|WP_011753772.1|298299_298785_+|tRNA-adenosine-deaminase-associated-protein
MADQVDGIDFALAAYREGGAWTVQELAHDVLEDIDTLSAALRRFPGDGGAVGMVAIEEDFFVVVRVAGPTTRVLLSDITAADEWELASSAVEFLGLPLPEDEDDPVPAGDLDLLGDLGMHAMDMGVLLDDIDLYPDEMLSDVARRLGFGKLFDDAVGLTSA
>NC_008699.1|WP_011753773.1|298808_299240_+|nucleoside-deaminase
MRTALDEARAALASGDVPIGAVVLDPDGTPVARGRNVREADHDPTGHAEVVALRAAARARGEWRLEGHTLVVTLEPCTMCAGAAVLSRVERIVFGAWDPKAGAVGSLWDVVRDRRLNHRPEVISGVLAEESAGLLEDFFLTQR
>NC_008699.1|WP_041547030.1|299302_299674_+|VOC-family-protein
MDYKIELIPLAVRDVDRSIAFYGDSLGWSVDHDQTVSPTLRFVQVTPPGSACSICFGVGLEMMPAGSSQFIQVVVADADAALAELRERGVGCEGVDDQPWGRFVYFQDPDGNRWALQQVVRPS
>NC_008699.1|WP_011753775.1|299701_301321_-|FMN-binding-glutamate-synthase-family-protein
MRKTTLAALPAAALGAVAAHDLLQRRHAILRNFPVVGHARYWLEALGPELRQYIVASNDEERPFSRDQRRWVYASAKLQNNYFGFGTDNDLEHSSGNVIVHHRTFGRSYPTHGAVGQEARLPSAKILGGPRGRRRAFRPASVVNVSGMSFGSLSGNAVEAINRGAAEAGCLHNTGEGAVSPYHRQGADLVFQIGTAYFGCRDDDGRFSLPRLKDLVESAPVRALEIKLSQGAKPGLGGVLPAAKVSAEIAATRGVPAGLDCLSPSRHAEFDDVDSLLDFVELLADETGLPVGIKSAVGDLGFWRDLTEEMAKGQRGVDFVTIDGGEGGTGASPLIFTDAVSLPFRLGFARVYAEFARRGLHEDVTFIGSGKLGLPDNAVVAFALGADLVNVAREAMLAVGCIQAQKCHTGECPTGVATQNPWLAHGLDPVEKSGRVANYVRTLRRDLLKVAETCGVEHPGLIGPHDVEILDNLSDGRLLDEVYGYDPGWGFPSARDRQEIAAIMSATEEPETRTEGPPETAEEGAPGTEHAGDEEPSGD
>NC_008699.1|WP_011753776.1|301390_302623_+|alpha-hydroxy-acid-oxidizing-protein
MKRQLPRRRDLAPLVRFRTPVLSPRGRRLRDALTIEDLRRAARRRTPRAAFDYTDGAADDEISLARARQAFRDVQFNPGVLRDVSSVDTSREVLGARASLPFGIAPTGFTRLMHTEGEVAGATAAAAAGIPFALSTMGTTSIEDVAAAAPSGRHWFQLYMWKDRDRSMALVERAARAGFDALLVTVDVPVAGARLRDVRNGMTIPPTLTPRTVLDAIPRMRWWFDLLTTEPLAFATLDSWSGTVAELLDTMFDPTVTFEDLAWIKEQWPGRLVVKGIQTVDDARRVADLGADAVLLSNHGGRQLDRAPIPFRLLPEVVAAVGQDVEVHLDTGIMSGQDIVAALAHGARFTLVGRAYLYGLMAGGRDGVDRAVEILRSQVERTMRLLGVRSLGDLEPGHVTQLDRLEPRRR
>NC_008699.1|WP_011753777.1|302654_303251_+|CocE/NonD-family-hydrolase
MNRYAAALVVALSALVAPPAHAASAHATSAAQEAWSPRPEIYPATVTRTDLAVPMSDGVVLRGDLVLPAGADGRAVRGRFPVIVTITAYNKTALSSGGGVAGAPPAYLVQRGYAQLTVDARGTGSSEGQWSAFGARENEDSAEVVEWAHSRKRPWSDGRVGMSGPITARLYTSSVSGDGMLSVSVSDVAPDGTVSRLS

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Crispr_ID: NC_008699_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_7

361176-361260

Orphan

Consensus_repeat	Method
CGGTTTCCCCGGTTCACCGGGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_7

>merge|NC_008699|7|361176-361260|CRISPRCasFinder
CGGTTTCCCCGGTTCACCGGGGATGTTGGAACTTCTGGCCCGAAGTTTCGGCCCAACAGTTCCGGTTTCCCCGGTTCACCGGGGA

>NC_008699|7|7|361176-361260|CRISPRCasFinder
CGGTTTCCCCGGTTCACCGGGGA	TGTTGGAACTTCTGGCCCGAAGTTTCGGCCCAACAGTTC
CGGTTTCCCCGGTTCACCGGGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011753826.1\|354972_355617_+\|CoA-transferase-subunit-B	unknown	unknown	gnl\|CDD\|188219
NC_008699.1\|WP_011753841.1\|367343_369338_-\|acetate--CoA-ligase	unknown	unknown	gnl\|CDD\|234677
NC_008699.1\|WP_011753834.1\|361274_361952_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_008699.1\|WP_011753830.1\|358834_358990_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379366
NC_008699.1\|WP_172419808.1\|351884_353969_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223082
NC_008699.1\|WP_011753838.1\|364135_365311_+\|MarP-family-serine-protease	unknown	unknown	gnl\|CDD\|379142
NC_008699.1\|WP_083768047.1\|362041_362815_+\|endonuclease-III	unknown	unknown	gnl\|CDD\|223255
NC_008699.1\|WP_011753831.1\|358986_359451_+\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100006
NC_008699.1\|WP_011753829.1\|357822_358725_+\|FliA/WhiG-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274153
NC_008699.1\|WP_011753840.1\|365913_367218_-\|Na+/H+-antiporter-NhaA	unknown	unknown	gnl\|CDD\|184855
NC_008699.1\|WP_011753825.1\|354202_354976_+\|CoA-transferase-subunit-A	unknown	unknown	gnl\|CDD\|224702
NC_008699.1\|WP_011753836.1\|362811_363423_+\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NC_008699.1\|WP_011753843.1\|371071_371434_-\|DUF485-domain-containing-protein	unknown	unknown	gnl\|CDD\|377315
NC_008699.1\|WP_083768250.1\|360413_361157_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293836
NC_008699.1\|WP_011753839.1\|365472_365892_-\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377816
NC_008699.1\|WP_011753842.1\|369470_371075_-\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
NC_008699.1\|WP_140403781.1\|355712_356573_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274153
NC_008699.1\|WP_011753832.1\|359461_360334_+\|NUDIX-hydrolase	unknown	unknown	unknown
NC_008699.1\|WP_049774190.1\|356846_357617_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274153
NC_008699.1\|WP_140403794.1\|363533_364139_+\|CoA-pyrophosphatase	unknown	unknown	gnl\|CDD\|239518

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011753826.1\|354972_355617_+\|CoA-transferase-subunit-B	gnl\|CDD\|188219	TIGR02428, 3-oxoadipate_CoA-transferase_subunit_B, 3-oxoacid CoA-transferase, B subunit. Various members of this family are characterized as the B subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The A subunit represents a different clade in pfam01144.	1.74713e-122
NC_008699.1\|WP_011753841.1\|367343_369338_-\|acetate--CoA-ligase	gnl\|CDD\|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NC_008699.1\|WP_011753834.1\|361274_361952_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	4.48476e-55
NC_008699.1\|WP_011753830.1\|358834_358990_+\|hypothetical-protein	gnl\|CDD\|379366	pfam13783, DUF4177, Domain of unknown function (DUF4177).	7.63858e-05
NC_008699.1\|WP_172419808.1\|351884_353969_-\|AAA-family-ATPase	gnl\|CDD\|223082	COG0003, ArsA, Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning].	8.87056e-49
NC_008699.1\|WP_011753838.1\|364135_365311_+\|MarP-family-serine-protease	gnl\|CDD\|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	5.27216e-16
NC_008699.1\|WP_083768047.1\|362041_362815_+\|endonuclease-III	gnl\|CDD\|223255	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair].	7.78158e-91
NC_008699.1\|WP_011753831.1\|358986_359451_+\|RidA-family-protein	gnl\|CDD\|100006	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	1.69252e-68
NC_008699.1\|WP_011753829.1\|357822_358725_+\|FliA/WhiG-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274153	TIGR02479, RNA_polymerase_sigma_factor_WhiG, RNA polymerase sigma factor, FliA/WhiG family. Most members of this family are the flagellar operon sigma factor FliA, controlling transcription of bacterial flagellar genes by RNA polymerase. An exception is the sigma factor WhiG in the genus Streptomyces, involved in the production of sporulating aerial mycelium.	1.47924e-64
NC_008699.1\|WP_011753840.1\|365913_367218_-\|Na+/H+-antiporter-NhaA	gnl\|CDD\|184855	PRK14853, nhaA, pH-dependent sodium/proton antiporter; Provisional.	0
NC_008699.1\|WP_011753825.1\|354202_354976_+\|CoA-transferase-subunit-A	gnl\|CDD\|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	1.57086e-98
NC_008699.1\|WP_011753836.1\|362811_363423_+\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	7.15638e-31
NC_008699.1\|WP_011753843.1\|371071_371434_-\|DUF485-domain-containing-protein	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	6.04905e-31
NC_008699.1\|WP_083768250.1\|360413_361157_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293836	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.46484e-69
NC_008699.1\|WP_011753839.1\|365472_365892_-\|phage-holin-family-protein	gnl\|CDD\|377816	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III. Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.	4.81267e-25
NC_008699.1\|WP_011753842.1\|369470_371075_-\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NC_008699.1\|WP_140403781.1\|355712_356573_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274153	TIGR02479, RNA_polymerase_sigma_factor_WhiG, RNA polymerase sigma factor, FliA/WhiG family. Most members of this family are the flagellar operon sigma factor FliA, controlling transcription of bacterial flagellar genes by RNA polymerase. An exception is the sigma factor WhiG in the genus Streptomyces, involved in the production of sporulating aerial mycelium.	9.96459e-57
NC_008699.1\|WP_049774190.1\|356846_357617_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274153	TIGR02479, RNA_polymerase_sigma_factor_WhiG, RNA polymerase sigma factor, FliA/WhiG family. Most members of this family are the flagellar operon sigma factor FliA, controlling transcription of bacterial flagellar genes by RNA polymerase. An exception is the sigma factor WhiG in the genus Streptomyces, involved in the production of sporulating aerial mycelium.	8.31286e-19
NC_008699.1\|WP_140403794.1\|363533_364139_+\|CoA-pyrophosphatase	gnl\|CDD\|239518	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.	8.75022e-53

>NC_008699.1|WP_083768250.1|360413_361157_+|MBL-fold-metallo-hydrolase
MTLDGTNTWVLREPGARRSVVVDPGPALPAHLDAIAAEAGEVGVVLLTHHHADHAEAARAFAERVGCGVRALDPAYRLGAEGLGDGDVVAVDGLEIRVVGTPGHTADSLSFLLPAEGAVLTGDTVLGRGTTVVAHPDGQLGAYLGSLDRLHALAEAHEVASIWPGHGPVIVNALGALDHYLAHRQERLEQVRAAVETLQAAHRPEGIAAEELPRRVVEIVYADVDPVLWGAAELSVRAQLAYLAEPR
>NC_008699.1|WP_011753832.1|359461_360334_+|NUDIX-hydrolase
MRIPIPPIPLPEQIVELAREYDDGRRDPAEPRDAATVILVRPSDHGPAVYYLRRHTTMEFAGGMCVYPGGGVDPRDFDTTVAWAGPAPAEWAERLGCDEEMARALVCAAVRETFEESGVLLAGPSADEVVADTTGEDWEADRHALESRELAMTAFLSARGLVLRTDLLGVWGGWLTPAFEPKRYRTWFFVALLPEGQRTRDVSTESESVTWLPAADAVAQAERGEMLMMPPTYLTSLEVAQLATPDEVIVAAHGRVVEMHTPVVEPLDGEGWTLSVPAHHRSILAAHRGA
>NC_008699.1|WP_011753831.1|358986_359451_+|RidA-family-protein
MTSPEERLAELGLAVPDVAKPVAVYVPAVVSGDLVFTSGQLPMRDGELMVTGKVGGEVSPEEAALCAQQCALNAIAAVKSMVGDLDRVAQVVKVVAFVASTPDFTGQPQVANGASELFGKVFGDRGAHARSAVGVPVLPLDAPVEVEIVVRVAS
>NC_008699.1|WP_011753830.1|358834_358990_+|hypothetical-protein
MTKWEYLTAPILTHAAKQILDNFGADGWELVQVAPGPNPENLVGFFKRPLA
>NC_008699.1|WP_011753829.1|357822_358725_+|FliA/WhiG-family-RNA-polymerase-sigma-factor
MTDPEVNEPDTPTAATSGPGPRPGSAEADRLAVEHVPLVTHVVYETLARVPSYVDRNDLRSAGLLALVAAARSFDPERGVPFARYAMPRIRGAMVDELRSVDWASRSVRRRAREIEEARARLAATLGEFPDDEAVAAALGMTLDEVNRVDSEAARGTVLPLDAGAQQGLAEILPVREAGPEERAVHLERVRYLADAVEELPERMRLVVRGYFLEERPMAELAAELGVTESRVSQVRAEALALLRDALGEAFDPHLPKPHPNPAGVAARRRLAYTSAVAARYAARRTMPARRPHRGLESTA
>NC_008699.1|WP_049774190.1|356846_357617_+|sigma-70-family-RNA-polymerase-sigma-factor
MTINAPGPAPTVDPARLAAHHLPLVAHLVYDTLRRVPAAVDRHDLLAVGVDALLAAAREPTVERPFAEHASVRIRAALVEELRAIDWAARAEHPRHAASARARLLAALADLPDAGAAARVLDVDHDPAEAEEGSPAVVGGTTRPAHPDRRDERREYVEAALDELPERLRLVVRGYFVEQRPMAAVAAQVGASEARAVQLLVEGLGLLRDALALAFGPSADAGPVTSTRAASYARTVAARYAARPVRAPREEQRTSA
>NC_008699.1|WP_140403781.1|355712_356573_-|sigma-70-family-RNA-polymerase-sigma-factor
MNSGRSTPMTIAERDQLAVQHVPLVAHLVRETMARVPSYMDRNDLHSAGLLALVQAARAFDPERGVPFAGYASTRIRGALVDELRSVDWASRSVRRRAREIEAARARLAATLGQFPDDAAVAEALGITPEEIGKADSEVARAVVLPLDAGPNAGFVESLAGRDPGPEEEALHAERAQYLAAAIEELPERLRHVVRGYFVAQRPMAELAAELGVSESRISQLRAEALVLLRDALAEAFEPHLAAPHPNPDGVAARRRLAYTSAVAARYAARRTMPAARVREGLSSIA
>NC_008699.1|WP_011753826.1|354972_355617_+|CoA-transferase-subunit-B
MSWSREEMAARAASELSDGSYVNLGIGLPTMVPNYVGDDVELVLQSENGILGVGAYPFDGEEDPDLINAGKETVTLRRGASFFDSATSFGMIRGGKIDAAILGAMQVSKAGDIANWMIPGKMVKGMGGAMDLVHGAKRVIVLMEHVAKDGSYKIVEECSLPYTGKGVVQRIITDLAVIDVTREGLELVELAPGVSLDEVREKTEPELVAANVES
>NC_008699.1|WP_011753825.1|354202_354976_+|CoA-transferase-subunit-A
MDKVVASATAAVADIPDGVTLSVGGFGLCGIPSVLIQAVLDRGTQDLEVVSNNAGVDGWGLGLLLGAGRLRRVVASYVGENKEFARQYLSGELEVELTPQGTLAERMRAGGSGIPAFFTATGVGTQVAEGGLPWRYDAEGAVVKSSPAKQTQVFETAEGPKEFVLEHAIVADFGLVRAWKGDRHGNLVFRDSARNFNPLAAMCGRVTIAEVEHLVEPGELDPNQVHTPGVFVQRVVELTPEQAADKRIEKKTVRARG
>NC_008699.1|WP_172419808.1|351884_353969_-|AAA-family-ATPase
MRGRGAAGDRPDVRRRPAALRGASDRDRAAPRRPTTRRRARAAHRRGVRAAGVPRDVLQARPRGSRTRPLRRHRVRDHDRSGRPRRTAHREGLRGGAAQQPQPQRHPVRRRRAGRPADRADHPVPQRERGAGRACQGRADQGPGRHRDDVVPVTTDAGSSRHGPRGDACAGDRRRDLRAACRPVAGRRGHRQPGAAPGHHARGPRGRRRRPPRHRADRGRPGPGRRDRGDRAGGGADRRGPRPRRAAGPGGRAARGRRLLRVADVRAAAADQRRRPRRPVRAGRRPEEPGAGVSTARKTRTRTRVGPLATAPTAAPALDVDALLDDRGTGIIVCCGSGGVGKTTASAALALRAAERGRRVVVLTIDPARRLAQSMGIEQLDNTPRPVTGLRTNAKGNRKGGGLDAMMLDMKRTFDEVVESQANPEKARLILDNPFYIALSSSFAGTQEYMAMEKLGQLHADARRDGTYDLIVVDTPPSRSALDFLDAPERLSSFLDGRFIRLLLTPARGPARMMTAGLGLITNALNRILGTQVLRDMQTFVAAFDTLFGGFRVRAQKTFELLQADGTAFLVVAAPEPDALREAAYFVERLSEDDMPLAGLIVNRATPVPPGSLSADEAMAASERLRKQDPDSLTAGLLCLHADQTRIVEREALLRDRFAAAHPQVPTAVVPALAGDVHDLDGLRRVGELLARSG
>NC_008699.1|WP_011753834.1|361274_361952_-|Crp/Fnr-family-transcriptional-regulator
MDNDVLRQAPLFSALDDEAATALRASMTESKLRRGDVLFHEGDSGDKLYIVLDGKVKLGRTSSDGRENLLAILGPGQMFGELSLFDPGPRSATVTAVTDATFASLSHEDLLRWLEGRPVVARGLLTQLAGRLRKANDVVADLVFSDVPGRVAKALLDLADRFGRSADDGVHVHHDLTQEELAQLVGASRETVNKALADFASRGWLRLEPRSVVIMDVERLGRRAR
>NC_008699.1|WP_083768047.1|362041_362815_+|endonuclease-III
MSGCAVRSPTTGWSVPRRTLGPVPAVPESRTGLVRRARKIDRLLAETYPDARCELDFDNPFELLVVTVLSAQTTDKRVNAVRPTLFAAYPDARTMAGADRATLEGIVGPLGFFRAKTESLLKLSAALVERHGGEVPPRLDDLVQLPGVGRKTANVVLGNAFGIPGITVDTHFGRLSRRFAWTEETDPVKVEHAVGALFEKRDWTMLSHHLIWHGRRICHARNPACGACPVARWCPAYGEGPTDPAAAAKLVKTEGRA
>NC_008699.1|WP_011753836.1|362811_363423_+|TlpA-family-protein-disulfide-reductase
MRRLLPAVLAAAVLVLGACGSADLPKPPGQAKVDVDTPELRAIRADAGIEPCRQAAGAAVDGGLPDVTLPCLGGGPDVDLAGLRGPVVVNLWASWCGPCRKELPIYQQFHERYGDRVGVVGIDYNDVQPKAALELARDTGVTYPLLADPGSTLEGTESFPTIPGLPWVVLVDADGKVVHKQAIEITSVDQLVGLVDEHLGTDL
>NC_008699.1|WP_140403794.1|363533_364139_+|CoA-pyrophosphatase
MLFGAGEQGGELLLTERAHDMRSHPGQVSFPGGALDPGETPVEAALREAEEEVGVDPASVEVFGRLPELWLPPSNFAVTPVLGWWREPGDVSIVSQAEVHAIHHVPISELLDPEHRITVRHPRGGYQSPGFLIGPDHDVVLWGFTGGIIARLFDFLGWTRPWDESRLRDLPSYMLQADPRRGRLLDIEDDQDDDQDEEEDG
>NC_008699.1|WP_011753838.1|364135_365311_+|MarP-family-serine-protease
MNLLDWLLVVLVLAYALSGYWQGFITGAFATGGLLLGGLFGVWLAPVALGDANPSLMVSLGALFIVILSASLGQAVLQFAGARIRERITWQPARALDAVGGAMLSAVAVLVVAWALGVAISGSRIGGVTPLVRGSTVLSHVDEVMPASADGALQAFNDVVGTSFFPRYLEPFAPERIVEVGPGPKRLLNDPDVERAGSSVLKIRGTNECGRGVEGSGFLYAGNRLMTNAHVVAGIDDPEVIVGDESVPADVVYYNPDIDVAVLSFDSGDLPALRFDRDAGAPDGVAILGYPQDGPYHVEPARIRSEQRLRSPNIYGDGAVIREVYSLRGRILPGNSGGPIVSSAGDVVGVVFAASVTDHETGYALTAGQVSAAAAAGLTSSSQVSTGGCAG
>NC_008699.1|WP_011753839.1|365472_365892_-|phage-holin-family-protein
MASNQVQAAPPDEGDPTIGRLVHDASRDISTLIQKEIQLAKSELKVSVQAGGIGIGLFAAAGFIAVLAVIMLSVAIAYFINWNGDGLALHWAFLIVFGFYLLLAGLMVFVGIRKVKQVRAPERAIEQGREIPKALKGRS
>NC_008699.1|WP_011753840.1|365913_367218_-|Na+/H+-antiporter-NhaA
MTGRRPTRPRLFSRGSFLESSRVADILRAETTGGLLLIAAATVAIVWANTPWSASYADLRDLRVGPQAWHLDLTLGAWAADGLLAIFFFVAGLELKREFVAGDLRDPRRAALPVVAAMGGMAVPALVYVLWNLGGDGALQGWAIPTATDIAFAVAILAVISTHLPTGLRTFLLTLAVVDDLLAITIIALFYTDELHLGYLAAAAVPLLVFALLVQRRIHRGWLLIPLAATAWVLVHESGVHATVAGVLLGFAVPVLRSDGQEGPGLAEHLEHLVRPLSAGLAVPVFAFFAAGVTVGGFDGLVDALSDPVALGVVTGLVVGKTVGIAGSTWLLATFTRADLDDQLSWVDVVGLAMLAGIGFTVSLLIGELAFGSGTPRDDHVKVGVLVGSLAATALATGVLRMRNRAYRRLVEIEEQDADADGVPDVYQRDADEG
>NC_008699.1|WP_011753841.1|367343_369338_-|acetate--CoA-ligase
MSDETLSNLLKEERRFEPPAEIAAKANLQADAYDRAAADPQAFWAEQAERLDWDQRWDRVLDWDDPPFAKWFVGGRLNAAYNCVDRHVAAGRGDKVALHWVGEPLDDTRDITYAELQDEVCRAANALTDLGVRTGDRVAIYLPMIPEAVVAMLACARIGAPHTVVFGGFSADALASRLEDCQAKVVVTSDGGYRRGSASALKPAVDEARAKTAARGHTVEKVLVVRRTGQDVAWDDAVDLWWHDAVGGASSEHTPEFFDAEHPLYVMYTSGTTGKPKGILHTTGGYLVGSAYTHWAVFDLKPDTDVYWCSADIGWVTGHSYLVYGPLANGATQVMYEGTPDSPERGRWWKIIQDYQVSIFYTAPTAIRSFMKQGREIPDGFDMSSLRILGSVGEPINPEAYIWYRHVIGDDRTPVVDTWWQTETGAIMISPLPGVTAGKPGSAMTPIPGVSAEVVNDEGDPVPNGSGGYLVLTAPWPAMLRTIWGDDQRYRDTYWSRFAKQGYYFAGDGAKKDDDGDIWVLGRVDDVMNVSGHRLSTTEIESALVSHPKVAEAAVVGAKDEDTGQAVCAFVILRESASDPGASDGGDDIVAELRQHVRKEIGPIATPRQIMIVPELPKTRSGKIMRRLLRDVAEHREVGDVTTLADSSVMDLIAQGLGSGKSEE
>NC_008699.1|WP_011753842.1|369470_371075_-|cation-acetate-symporter
MSSDTLTAILFIGVVLITIAITFWASRQNKGTADFYAAGRSFSGFQNGMAISGDYMSAASFLGISGAIALYGYDGFLYSIGFLVAWLVALLLVAELLRNSGRYTMADQLAYRMRQRPVRTAASTSTVVVSIFYLLAQMVGAGALVALLLGADSEAAKNATIIGVGVLMIFYVTVGGMKGTTWVQIVKAVLLMGGTILITILVLAKFNFNISDLLGAAAANTGKGDAFLQPGLKYGIDTTAKIDFLSLGLALVLGTAGLPHILIRFYTVPSAKAARTSVLWAIGLIGAFYLMTLALGFGAAALLDTGAGSKVAASGGNLASPLLAEAVGGGDGTTGGAVLLALISAVAFATILAVVAGLTLTSASSVAHDLYATVFKKGAATERDEVRVARLSAFVIGGIAIALAIPAQKLNIAFLVALAFAVAASANLPSLIYNLFWRRFNTRGATWAIYGGLIASVGLVFFSPVVSGSETALFTGQDWSYFPLSNPGIISIPLGFFFGWLGTVTSQEPESAARFTELEVRAFTGAGAEQAVRH
>NC_008699.1|WP_011753843.1|371071_371434_-|DUF485-domain-containing-protein
MSDLDQTAGQAHRHDPVYDELHASPEFNRLRSLYRGFAFPATIAFLAWYLLYVVMSNWATGFMDTKLSGNINLALVFGLLQFLTTFAIAWLYARYMNRNVDPIARALEKKYNDRPGGGAR

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Crispr_ID: NC_008699_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_8

375273-375388

Orphan

Consensus_repeat	Method
GCAACCGTTGGGGGCGCTCATTCGGTTACCTGCTCACCGCTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_8

>merge|NC_008699|8|375273-375388|CRISPRCasFinder
GCAACCGTTGGGGGCGCTCATTCGGTTACCTGCTCACCGCTGGCCGGGGGTGGCGGGGGTGGGCGGTGTGTCCGCAACCGTTGGGGGCGCTCATTCGGTTGCCTGCTCACCGCTGG

>NC_008699|8|8|375273-375388|CRISPRCasFinder
GCAACCGTTGGGGGCGCTCATTCGGTTACCTGCTCACCGCTGG	CCGGGGGTGGCGGGGGTGGGCGGTGTGTCC
GCAACCGTTGGGGGCGCTCATTCGGTTGCCTGCTCACCGCTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011753841.1\|367343_369338_-\|acetate--CoA-ligase	unknown	unknown	gnl\|CDD\|234677
NC_008699.1\|WP_011753855.1\|385392_386220_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NC_008699.1\|WP_011753854.1\|384576_385362_-\|carbonic-anhydrase-family-protein	unknown	unknown	gnl\|CDD\|239398
NC_008699.1\|WP_041547046.1\|380813_382319_-\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
NC_008699.1\|WP_011753846.1\|375403_376786_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224171
NC_008699.1\|WP_011753845.1\|373203_375246_+\|molybdopterin-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|239155
NC_008699.1\|WP_011753836.1\|362811_363423_+\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NC_008699.1\|WP_011753844.1\|371695_373204_+\|NarK/NasA-family-nitrate-transporter	unknown	unknown	gnl\|CDD\|184994
NC_008699.1\|WP_140403794.1\|363533_364139_+\|CoA-pyrophosphatase	unknown	unknown	gnl\|CDD\|239518
NC_008699.1\|WP_011753838.1\|364135_365311_+\|MarP-family-serine-protease	unknown	unknown	gnl\|CDD\|379142
NC_008699.1\|WP_011753840.1\|365913_367218_-\|Na+/H+-antiporter-NhaA	unknown	unknown	gnl\|CDD\|184855
NC_008699.1\|WP_011753847.1\|376782_379299_+\|nitrite-reductase-large-subunit	unknown	unknown	gnl\|CDD\|184951
NC_008699.1\|WP_011753849.1\|379669_380788_+\|uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|235981
NC_008699.1\|WP_011753843.1\|371071_371434_-\|DUF485-domain-containing-protein	unknown	unknown	gnl\|CDD\|377315
NC_008699.1\|WP_011753839.1\|365472_365892_-\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377816
NC_008699.1\|WP_011753852.1\|382701_383451_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_008699.1\|WP_011753842.1\|369470_371075_-\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
NC_008699.1\|WP_011753848.1\|379295_379673_+\|nitrite-reductase-small-subunit-NirD	unknown	unknown	gnl\|CDD\|239605
NC_008699.1\|WP_140403782.1\|383447_384563_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NC_008699.1\|WP_011753851.1\|382327_382705_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340990

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011753841.1\|367343_369338_-\|acetate--CoA-ligase	gnl\|CDD\|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NC_008699.1\|WP_011753855.1\|385392_386220_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.35065e-26
NC_008699.1\|WP_011753854.1\|384576_385362_-\|carbonic-anhydrase-family-protein	gnl\|CDD\|239398	cd03124, alpha_CA_prokaryotic_like, Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.	1.78143e-92
NC_008699.1\|WP_041547046.1\|380813_382319_-\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	9.82732e-134
NC_008699.1\|WP_011753846.1\|375403_376786_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224171	COG1251, NirB, NAD(P)H-nitrite reductase [Energy production and conversion].	8.99871e-112
NC_008699.1\|WP_011753845.1\|373203_375246_+\|molybdopterin-oxidoreductase-family-protein	gnl\|CDD\|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NC_008699.1\|WP_011753836.1\|362811_363423_+\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	7.15638e-31
NC_008699.1\|WP_011753844.1\|371695_373204_+\|NarK/NasA-family-nitrate-transporter	gnl\|CDD\|184994	PRK15034, PRK15034, nitrate/nitrite transport protein NarU; Provisional.	2.09954e-106
NC_008699.1\|WP_140403794.1\|363533_364139_+\|CoA-pyrophosphatase	gnl\|CDD\|239518	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.	8.75022e-53
NC_008699.1\|WP_011753838.1\|364135_365311_+\|MarP-family-serine-protease	gnl\|CDD\|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	5.27216e-16
NC_008699.1\|WP_011753840.1\|365913_367218_-\|Na+/H+-antiporter-NhaA	gnl\|CDD\|184855	PRK14853, nhaA, pH-dependent sodium/proton antiporter; Provisional.	0
NC_008699.1\|WP_011753847.1\|376782_379299_+\|nitrite-reductase-large-subunit	gnl\|CDD\|184951	PRK14989, PRK14989, nitrite reductase subunit NirD; Provisional.	0
NC_008699.1\|WP_011753849.1\|379669_380788_+\|uroporphyrinogen-III-synthase	gnl\|CDD\|235981	PRK07239, PRK07239, bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated.	1.77539e-162
NC_008699.1\|WP_011753843.1\|371071_371434_-\|DUF485-domain-containing-protein	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	6.04905e-31
NC_008699.1\|WP_011753839.1\|365472_365892_-\|phage-holin-family-protein	gnl\|CDD\|377816	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III. Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.	4.81267e-25
NC_008699.1\|WP_011753852.1\|382701_383451_-\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	3.38456e-52
NC_008699.1\|WP_011753842.1\|369470_371075_-\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NC_008699.1\|WP_011753848.1\|379295_379673_+\|nitrite-reductase-small-subunit-NirD	gnl\|CDD\|239605	cd03529, Rieske_NirD, Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while fungal proteins have a C-terminal Rieske domain in addition to several other domains. The fungal NirD is involved in nutrient acquisition, functioning at the soil/fungus interface to control nutrient exchange between the fungus and the host plant. The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The Rieske [2Fe-2S] cluster is liganded to two histidine and two cysteine residues present in conserved sequences called Rieske motifs. In this family, only a few members contain these residues. Other members may have lost the ability to bind the Rieske [2Fe-2S] cluster.	4.31393e-53
NC_008699.1\|WP_140403782.1\|383447_384563_-\|histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	1.03855e-77
NC_008699.1\|WP_011753851.1\|382327_382705_-\|hypothetical-protein	gnl\|CDD\|340990	cd17432, MFS_GLUT_Class2, Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0.0075802

>NC_008699.1|WP_011753845.1|373203_375246_+|molybdopterin-oxidoreductase-family-protein
MTQTHCPYCSLQCGMRLEGGRRLEVRPWPEFPVNEGALCRKGWTAAGLRGHRERLTTPLIRDRATGELRAAGWDEALDLVASRLCGLRDEHGPDSVAVFGGGGLTNEKAYQLGKLARVALGTSQVDYNGRWCMSSAASAGNRALGIDRGLPFPLADVEHTDVLVLVGSNLAETMPPAARHLDRLRENGGRVVVVDPRRTPTAERADLFLQPVPGTDLPLALGLLHLLDAAGAVAEEYVAARTTGWEEVRRSLAGWWPERVERVAGVQASQLRECADLLAGAERVMVLTARGAEQHAQGTDTVLAWIDLALALGMPGKQYAGYGCLTGQGNGQGGREHGQKADQLPGYRMIDDPLARDHVAEVWGVSTDSLPGPGRSAYELLDSLGTGGGPRALLVVGSNIVVSAPNATHVASRLAALDLLVVADLVLSETAAQADVVLPVAQWAEETGTMTNLEGRVILRERAVAPPEGVRTDLEVIAGLAERLGSPVPFAVDPEEVFAELGRASSGGRADYSGIGYDRIRDEHGVFWPCPSPDHPGTPRLFAESFPTADGRARFVAVEHRGPAEPTDPSYPIHLTTGRVLAQYQSGAQTRRVRELPDEGPFVEMHPMLAARIGAHDGQQVVVTTRRGELRVPARVTATIRPDTVFVPFHWVGANRLTHDALDPASRMPEFKVCAAAVRA
>NC_008699.1|WP_011753844.1|371695_373204_+|NarK/NasA-family-nitrate-transporter
MALTSLHTDAAEASPIRRRTGRWIDDWRPEDPDFWANGGQQVARRNLVWSVFAEHLGFSVWLIWSVSSAFLLAQGFTFTPQQLFLLVAIPNLVGSLLRVPYTLAVPRFGGRNWTMVSAGLLLVPTLGFAYAVTDPSTPYWVFCLIAASAGFGGGNFASSMANINFFYPTAKKGAALGLNAAGGNLGVSLIQFFLPLIVGGAAIFGLAKASPGGIHLERAAWVYAGLAIVATAAAYFFMDNLGTARSSAREQLGVLKHKQTWVMSFLYIGTFGSFIGYSAAMPLLIKLNFWVPEPAPLGTGIYFAYFAFLGALVGSITRPLGGWLADRYGGARVTLGAFTGIILSTLGVLWTLLQLTPNPAADPAIAADNKSWFPYFLGFFLLVFAATGIGNGSTYKMIPAIFRTEAERATAVGTEERTAALLAATKRASAAIGIIGAVGAIGGFLIPITFSSPWVSDPMEATKTAFVIFTVFYLACAATTWVVYLRRPAEHKAHLSYAGAGI
>NC_008699.1|WP_011753843.1|371071_371434_-|DUF485-domain-containing-protein
MSDLDQTAGQAHRHDPVYDELHASPEFNRLRSLYRGFAFPATIAFLAWYLLYVVMSNWATGFMDTKLSGNINLALVFGLLQFLTTFAIAWLYARYMNRNVDPIARALEKKYNDRPGGGAR
>NC_008699.1|WP_011753842.1|369470_371075_-|cation-acetate-symporter
MSSDTLTAILFIGVVLITIAITFWASRQNKGTADFYAAGRSFSGFQNGMAISGDYMSAASFLGISGAIALYGYDGFLYSIGFLVAWLVALLLVAELLRNSGRYTMADQLAYRMRQRPVRTAASTSTVVVSIFYLLAQMVGAGALVALLLGADSEAAKNATIIGVGVLMIFYVTVGGMKGTTWVQIVKAVLLMGGTILITILVLAKFNFNISDLLGAAAANTGKGDAFLQPGLKYGIDTTAKIDFLSLGLALVLGTAGLPHILIRFYTVPSAKAARTSVLWAIGLIGAFYLMTLALGFGAAALLDTGAGSKVAASGGNLASPLLAEAVGGGDGTTGGAVLLALISAVAFATILAVVAGLTLTSASSVAHDLYATVFKKGAATERDEVRVARLSAFVIGGIAIALAIPAQKLNIAFLVALAFAVAASANLPSLIYNLFWRRFNTRGATWAIYGGLIASVGLVFFSPVVSGSETALFTGQDWSYFPLSNPGIISIPLGFFFGWLGTVTSQEPESAARFTELEVRAFTGAGAEQAVRH
>NC_008699.1|WP_011753841.1|367343_369338_-|acetate--CoA-ligase
MSDETLSNLLKEERRFEPPAEIAAKANLQADAYDRAAADPQAFWAEQAERLDWDQRWDRVLDWDDPPFAKWFVGGRLNAAYNCVDRHVAAGRGDKVALHWVGEPLDDTRDITYAELQDEVCRAANALTDLGVRTGDRVAIYLPMIPEAVVAMLACARIGAPHTVVFGGFSADALASRLEDCQAKVVVTSDGGYRRGSASALKPAVDEARAKTAARGHTVEKVLVVRRTGQDVAWDDAVDLWWHDAVGGASSEHTPEFFDAEHPLYVMYTSGTTGKPKGILHTTGGYLVGSAYTHWAVFDLKPDTDVYWCSADIGWVTGHSYLVYGPLANGATQVMYEGTPDSPERGRWWKIIQDYQVSIFYTAPTAIRSFMKQGREIPDGFDMSSLRILGSVGEPINPEAYIWYRHVIGDDRTPVVDTWWQTETGAIMISPLPGVTAGKPGSAMTPIPGVSAEVVNDEGDPVPNGSGGYLVLTAPWPAMLRTIWGDDQRYRDTYWSRFAKQGYYFAGDGAKKDDDGDIWVLGRVDDVMNVSGHRLSTTEIESALVSHPKVAEAAVVGAKDEDTGQAVCAFVILRESASDPGASDGGDDIVAELRQHVRKEIGPIATPRQIMIVPELPKTRSGKIMRRLLRDVAEHREVGDVTTLADSSVMDLIAQGLGSGKSEE
>NC_008699.1|WP_011753840.1|365913_367218_-|Na+/H+-antiporter-NhaA
MTGRRPTRPRLFSRGSFLESSRVADILRAETTGGLLLIAAATVAIVWANTPWSASYADLRDLRVGPQAWHLDLTLGAWAADGLLAIFFFVAGLELKREFVAGDLRDPRRAALPVVAAMGGMAVPALVYVLWNLGGDGALQGWAIPTATDIAFAVAILAVISTHLPTGLRTFLLTLAVVDDLLAITIIALFYTDELHLGYLAAAAVPLLVFALLVQRRIHRGWLLIPLAATAWVLVHESGVHATVAGVLLGFAVPVLRSDGQEGPGLAEHLEHLVRPLSAGLAVPVFAFFAAGVTVGGFDGLVDALSDPVALGVVTGLVVGKTVGIAGSTWLLATFTRADLDDQLSWVDVVGLAMLAGIGFTVSLLIGELAFGSGTPRDDHVKVGVLVGSLAATALATGVLRMRNRAYRRLVEIEEQDADADGVPDVYQRDADEG
>NC_008699.1|WP_011753839.1|365472_365892_-|phage-holin-family-protein
MASNQVQAAPPDEGDPTIGRLVHDASRDISTLIQKEIQLAKSELKVSVQAGGIGIGLFAAAGFIAVLAVIMLSVAIAYFINWNGDGLALHWAFLIVFGFYLLLAGLMVFVGIRKVKQVRAPERAIEQGREIPKALKGRS
>NC_008699.1|WP_011753838.1|364135_365311_+|MarP-family-serine-protease
MNLLDWLLVVLVLAYALSGYWQGFITGAFATGGLLLGGLFGVWLAPVALGDANPSLMVSLGALFIVILSASLGQAVLQFAGARIRERITWQPARALDAVGGAMLSAVAVLVVAWALGVAISGSRIGGVTPLVRGSTVLSHVDEVMPASADGALQAFNDVVGTSFFPRYLEPFAPERIVEVGPGPKRLLNDPDVERAGSSVLKIRGTNECGRGVEGSGFLYAGNRLMTNAHVVAGIDDPEVIVGDESVPADVVYYNPDIDVAVLSFDSGDLPALRFDRDAGAPDGVAILGYPQDGPYHVEPARIRSEQRLRSPNIYGDGAVIREVYSLRGRILPGNSGGPIVSSAGDVVGVVFAASVTDHETGYALTAGQVSAAAAAGLTSSSQVSTGGCAG
>NC_008699.1|WP_140403794.1|363533_364139_+|CoA-pyrophosphatase
MLFGAGEQGGELLLTERAHDMRSHPGQVSFPGGALDPGETPVEAALREAEEEVGVDPASVEVFGRLPELWLPPSNFAVTPVLGWWREPGDVSIVSQAEVHAIHHVPISELLDPEHRITVRHPRGGYQSPGFLIGPDHDVVLWGFTGGIIARLFDFLGWTRPWDESRLRDLPSYMLQADPRRGRLLDIEDDQDDDQDEEEDG
>NC_008699.1|WP_011753836.1|362811_363423_+|TlpA-family-protein-disulfide-reductase
MRRLLPAVLAAAVLVLGACGSADLPKPPGQAKVDVDTPELRAIRADAGIEPCRQAAGAAVDGGLPDVTLPCLGGGPDVDLAGLRGPVVVNLWASWCGPCRKELPIYQQFHERYGDRVGVVGIDYNDVQPKAALELARDTGVTYPLLADPGSTLEGTESFPTIPGLPWVVLVDADGKVVHKQAIEITSVDQLVGLVDEHLGTDL
>NC_008699.1|WP_011753846.1|375403_376786_+|NAD(P)/FAD-dependent-oxidoreductase
MRVVVVGAGMAAARLADGLHDHDVTLLGDEPHPPYNRILLSAVLEGTHDPTAIAMPLRGDVDLRLGTRVVEIHREDRDVELADRSRVPYDRLVLATGSIPTLPPIRGLVRMDGRLDERVHAFRSLEDCRRLDVAVPAAHRAVVVGGGLLGLQVARALAVRGVATEVVEGGDHLLRSQVGPRAGAILARDLGRLGTRVYTGARAVRLTDEGLRLDNGYTLATDLVVLTAGGRPSTALARRAGLEVRRGIVVDERLRTSDHRIHAIGDCAQHGTQVTGFVPPAWEQAGLLARQLRGEDVTYAGSRSVARLRATGLEVAVLGEPERAEGQVVEVANPVTGTHRKLVVRDGVIVAATLVGDLSRIGLITQHYDRGTVLGASEPGDLLIGDRPAAQVDLPDDAEVCACAGVSAGAIRACASLADARETTRATTGCGGCAAAVRQLLAARLSPGPSLGTTLEGTPR
>NC_008699.1|WP_011753847.1|376782_379299_+|nitrite-reductase-large-subunit
MSPKHRRTLLVAGHGMVGHRFVQAAIERGLTETHDIVVVGEERRPAYDRVALTSFFEVGADELSFLPSGEYDDPRVRLLLGTSVDGFDPATRTVVLSDGQEIAYDELVLATGAMPFVPPVPGHDLEGCFVYRTIEDLEAIRAAAATAEVGAVVGGGLLGLEAANALAQLGLVTHVVEMAPRLMAVQVDEAGGATLARHIERLGLTVHTGATTQRILGADRVEGLALAGEEPIPADLVVFSAGIRPRDQLARDAGLDVAERGGVLVDERCRTSDPHVWAIGECAAPGGRMYGLVAPGYAMAEVVVDALLGGSGAFTGADLSTKLKLLGVDVASFGDAFAATEGALELVYADAVTGVYKKLVLSADGRQLLGGILVGDASAYGVLRPMVASGIALPDNPEDLILPTGRGVLEIGLPDEAQVCSCNDVTKGDILAAAAAGTSTRAGATCGSCKAQTKRIIEDYYASQGKVVDRSLCEHFALTRQELFDVVAVHGYTRFDDIVAGHGRGRGCDICKPAIASILASQLNGHVLDGPNRTLQDTNDAYLANIQRNGTYSVVPRIPGGEITPEKLIVIGEVAQEFGLYTKITGGQRIDLFGARMEQLPAIWRRLVDSGFESGHAYGKSLRTVKSCVGSTWCRYGVQDSVQLAIDLELRYRGLRSPHKLKGGVSGCARECAEARAKDFGVIATEKGWNLYVGGNGGATPAHARLLAGDLDRETLVRYLDRFLMYYVRTADRLQRTASWIDSIDGGLDRVREIVVDDALGLGSELEAAMARHVAGYFDEWRATLDDPAKLARFVSFVNAPGTPDPHITFRSERDQAVPEESSGPVDLGATIPVGAPR
>NC_008699.1|WP_011753848.1|379295_379673_+|nitrite-reductase-small-subunit-NirD
MSTSTGPAAGATYTTVCGLDQIEVEGGVVALVDGVAVAIFRTHDGNVYAISNYDPVSRASVLARGIVGTRGDVPVVASPMHKQAYDLRTGQCLDDAAVRVPTYDVRVIDGTVHVGGPRPEHQDST
>NC_008699.1|WP_011753849.1|379669_380788_+|uroporphyrinogen-III-synthase
MTDSLPLAGFRIGVTAARKVDEQVTLLERRGATVEWAPALSLDPNRVDDAALRAATEEVLAAPVDMILATTGIGMRTWFDAAERWGLLPRLLRALGSAEILARGPKSVGALRARGLRELWAPESECFEDVLEHLRGRSLAGLRIVVQEHGQSLSMVAHALRRQGAEVTTVTVYRVVSAEDPGPMFALVDLVADRSLDAVTFTSAPAVAALMDAAGSTGRRDELVSAFQADVVAACVGPVTAAAFEMWGVPTIFPERSRLGAMVKQLETELPVRRSGLAIGLVGGHRLLLHGEDVLLDGAEVRLSPAPAAVLQALVANPGNVVPRRALLAMLPSGTAGSEHAVEMAVARLRAALGTRTVQTVVKRGYRLAVAS
>NC_008699.1|WP_041547046.1|380813_382319_-|cation-acetate-symporter
MDAAPGIVAVAVVTIATLVIGTWGLRFSRTTSDFFVASRTVRPRLNASAIGGEYLSAASFLGVAGLVLTFGADMLWYPVGWTAGYLVLLVLVAAPLRRSGAYTLPDFAEARLGSRSVRAVCSLLVVAVGWLYLLPQFQGAGITLRSTLGAPTWVGPVIVGLVVLANVTSGGMRSITFVQAFQYWLKLTALLVPGAVLLVVWAGDSAPLRAGSDGWSVPLAAGGNQGLYVTYSLIIATFLGTMGLPHVVVRFYTNPDGRAARRTTLVVLALLGVFYLLPPLYGALGRVYAPSLAESGRSDALVLELPRIMLDGPAGEVLTGLVTAGAFAAFLSTSSGLSIAVSGVLSQDVTGRPWAGRRLGGVAAFRVGAVVAVTVPCVVALAAPNLGVARAVGLAFAMAASTFCPLLLLGIWWRRLTPAGALAGLLAGGVGSGVAIAWTLATSRPSGWADALMGQPAAWTFPLALTTMVVVSLATAHRIPTHAGRFLVRLHTPETLGLDRS
>NC_008699.1|WP_011753851.1|382327_382705_-|hypothetical-protein
MSEPGAAPERVRVTGPPRRRTPAARTADIDDETLLGGMYMGSLLREQLRLAVGVLTVLGLTLGLLPLAFHLFPRLGEVEVLGAPLAWVLLGVLAYPTLLLLGWVYVRRAERNERDFAELVSEVEG
>NC_008699.1|WP_011753852.1|382701_383451_-|response-regulator-transcription-factor
MSAPAAPVPRLRALVVDDERPALDELRYLLERDDRVREVLTTDSATEGLRILRDLDVDVVFLDIQMPGLTGLELAQVLSRFRTPPGIVFVTAHEAHAVEAFDVHAVDYVLKPVRADRLAEAVRRVVAGTDRAANGDDMRVAVERGGVTRFLNRSDITHVEAHGDYARLHTGDGSHLVRTPLAALEEEWAGAGFVRIHRSLLVSLAHVREVRMDAGRCAVVVGEPPVELGVSRRHTRELRELLLQYRTGP
>NC_008699.1|WP_140403782.1|383447_384563_-|histidine-kinase
MTRPWRRRHLGTEADRATFRTLHTASLASPALREGLTRTSAERSIRHLHDLLGGPALALTDTATTLAWHGTGQHHEEQCPGLAVATVERGRTRMFDREELPCDVSGCPVRSAIVSPLVVEERVIGTLQVFPAYATAGLARAADEVAQWVSSQLELAELDASRNRLMEAEVRALRAQISPHFIYNSLGAIASFVRTDPDRARDLLLEFADFTRYSFRRHGEYTTLAEELRSVERYLLLEQARFGDRLQVTLRIAPEVLPVAVPFLCIQPLVENAVRHGLETAERGGHIRIVARDQGQECVIEVEDDGTGEDPDVVRRALAGDAALDSTGLGNVDGRLRNAFGDDFGLAVETAPGAGTKVVVRVPKFAPGVHA
>NC_008699.1|WP_011753854.1|384576_385362_-|carbonic-anhydrase-family-protein
MNAARPNRRVRLLVVLCVALAAGSCSGDGDGTRTEPGDHGSEAGRAEHWSYDDVEAWEEACATGREQSPVDLAGATSRDLPDLGFAYRPAPATVVDNGHTVQASVEGAGSLELDCETFELRQLHFHSPSEHLVAGASYAAEVHLVHEGTDGRLAVVAVLVQEGSANPVVAALLDQVPAAGAEPVAADAPVDPVRVLPADRRAFRYDGSLTTPPCTEGVAWSVLAEPITWSAGQLAEFAERHPDSHRPPQPRDGRVLLHDER
>NC_008699.1|WP_011753855.1|385392_386220_-|methyltransferase-domain-containing-protein
MSDQPATSPALSFGDVAAAYDRGRPTYPRAAAAWAVGDQPTTVLELGAGTGKLTEVLVSLGHDVHATDPDEQMLAVLRERLPEVRTSVAAAEDIPAPDASYDVVVAAQAFHWFDHERALPEIARVLKPGGRLAVVWNARDERIPWVRRLGRIIGSQEQSRSEGPLENSTLFEALETESFRHWQLVDRDSIRDLVLSRSNVATLDETARADKLAEVVAFYDDYGRGMDGMQLPYVARCFRSALVAGAVTEDPGAGPAAEAPVTDGSDTEMLLIDFR

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Crispr_ID: NC_008699_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_9

455983-456067

Orphan

Consensus_repeat	Method
CGGTTTCCCCGGTTCACCGGGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_9

>merge|NC_008699|9|455983-456067|CRISPRCasFinder
CGGTTTCCCCGGTTCACCGGGGATGTTGGAACTTCTGGCCCGAAGTTTCGGCCCAACAGTTCCGGTTTCCCCGGTTAACCGGGGA

>NC_008699|9|9|455983-456067|CRISPRCasFinder
CGGTTTCCCCGGTTCACCGGGGA	TGTTGGAACTTCTGGCCCGAAGTTTCGGCCCAACAGTTC
CGGTTTCCCCGGTTAACCGGGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011753910.1\|449691_450126_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753924.1\|460687_461275_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NC_008699.1\|WP_011753914.1\|452286_453144_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187578
NC_008699.1\|WP_011753920.1\|457321_458134_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181131
NC_008699.1\|WP_011753912.1\|450722_451823_+\|endonuclease/exonuclease/phosphatase	unknown	unknown	gnl\|CDD\|197317
NC_008699.1\|WP_083768051.1\|454001_454358_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753917.1\|454354_454762_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753918.1\|454783_455962_+\|NADH:flavin-oxidoreductase	unknown	unknown	gnl\|CDD\|239201
NC_008699.1\|WP_140403800.1\|451815_452208_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|334619
NC_008699.1\|WP_011753921.1\|458143_459244_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293811
NC_008699.1\|WP_011753923.1\|459673_460591_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NC_008699.1\|WP_011753925.1\|461271_462150_+\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|132002
NC_008699.1\|WP_041546110.1\|449485_449665_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753926.1\|462412_463492_+\|thiamine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270263
NC_008699.1\|WP_083768252.1\|453118_454003_-\|putative-protein-N(5)-glutamine-methyltransferase	unknown	unknown	gnl\|CDD\|274733
NC_008699.1\|WP_011753922.1\|459233_459677_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225064
NC_008699.1\|WP_011753927.1\|463525_465160_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
NC_008699.1\|WP_140403786.1\|450124_450643_+\|ribonuclease-HI	unknown	unknown	gnl\|CDD\|260010
NC_008699.1\|WP_011753919.1\|456144_457266_+\|diacylglycerol-kinase	unknown	unknown	gnl\|CDD\|226326
NC_008699.1\|WP_011753928.1\|465159_466158_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011753924.1\|460687_461275_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	1.33036e-15
NC_008699.1\|WP_011753914.1\|452286_453144_+\|SDR-family-oxidoreductase	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.21057e-82
NC_008699.1\|WP_011753920.1\|457321_458134_+\|SDR-family-oxidoreductase	gnl\|CDD\|181131	PRK07814, PRK07814, SDR family oxidoreductase.	3.36733e-145
NC_008699.1\|WP_011753912.1\|450722_451823_+\|endonuclease/exonuclease/phosphatase	gnl\|CDD\|197317	cd09083, EEP-1, Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1. This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.	7.53065e-07
NC_008699.1\|WP_011753918.1\|454783_455962_+\|NADH:flavin-oxidoreductase	gnl\|CDD\|239201	cd02803, OYE_like_FMN_family, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	7.47233e-103
NC_008699.1\|WP_140403800.1\|451815_452208_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|334619	pfam01638, HxlR, HxlR-like helix-turn-helix. HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.	5.33829e-26
NC_008699.1\|WP_011753921.1\|458143_459244_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293811	cd07725, TTHA1429-like_MBL-fold, uncharacterized Thermus thermophilus TTHA1429 and related proteins; MBL-fold metallo hydrolase domain. Includes the MBL-fold metallo hydrolase domain of uncharacterized Thermus thermophilus TTHA1429 and related proteins. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.35187e-38
NC_008699.1\|WP_011753923.1\|459673_460591_-\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	6.98765e-45
NC_008699.1\|WP_011753925.1\|461271_462150_+\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	1.07248e-117
NC_008699.1\|WP_011753922.1\|459233_459677_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225064	COG2153, ElaA, Predicted acyltransferase [General function prediction only].	1.18896e-51
NC_008699.1\|WP_011753926.1\|462412_463492_+\|thiamine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270263	cd13545, PBP2_TbpA, Substrate binding domain of thiamin transporter, a member of the type 2 periplasmic binding fold superfamily. Thiamin-binding protein TbpA is the periplasmic component of ABC-type transporter in E. coli, while the transmembrane permease and ATPase are ThiP and ThiQ, respectively. Thiamin (vitamin B1) is an essential confactor in all living systems that most prokaryotes, plants, and fungi can synthesized thiamin. However, in vertebrates, thiamine cannot be synthesized and must therefore be obtained through dietary absorption. In addition to thiamin biosynthesis, most organisms can import thiamin using specific transporters. After binding thiamine with high affinity, TbpA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The thiamine-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.15104e-97
NC_008699.1\|WP_083768252.1\|453118_454003_-\|putative-protein-N(5)-glutamine-methyltransferase	gnl\|CDD\|274733	TIGR03704, PrmC_rel_meth, putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific. This protein family is closely related to two different families of protein-(glutamine-N5) methyltransferase. The first is PrmB, which modifies ribosomal protein L3 in some bacteria. The second is PrmC (HemK), which modifies peptide chain release factors 1 and 2 in most bacteria and also in eukaryotes. The glutamine side chain-binding motif NPPY shared by PrmB and PrmC is N[VAT]PY in this family. The protein substrate is unknown. [Protein synthesis, Ribosomal proteins: synthesis and modification].	9.49243e-94
NC_008699.1\|WP_011753927.1\|463525_465160_+\|iron-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	6.13979e-72
NC_008699.1\|WP_140403786.1\|450124_450643_+\|ribonuclease-HI	gnl\|CDD\|260010	cd09278, RNase_HI_prokaryote_like, RNase HI family found mainly in prokaryotes. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD), residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Prokaryotic RNase H varies greatly in domain structures and substrate specificities. Prokaryotes and some single-cell eukaryotes do not require RNase H for viability.	1.6896e-58
NC_008699.1\|WP_011753919.1\|456144_457266_+\|diacylglycerol-kinase	gnl\|CDD\|226326	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown].	1.25572e-81
NC_008699.1\|WP_011753928.1\|465159_466158_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	4.71041e-104

>NC_008699.1|WP_011753918.1|454783_455962_+|NADH:flavin-oxidoreductase
MTADVFAPTTLGPVRLRNRTVKAATFEGRAPHGQVTDELIDYHLAVTHGGVGLTTVAYLAVAPEGRTHREQIVVGEPTLAGLTRLADAIHESGAAIAGQVGHAGPVANGRSNGVKAISASRMPSPLSMQLIRSATEADLTRVTKAYVAASRLLVRAGFDVLELHMAHSYLISSFLAPGLNRRKDGWGGSLANRARLGRQVARAVRDEIGSDAAITAKVSVGDGFRGGVTTDEGIEYAQLLEADGTLDALQLSGGSSLMNPMYLFRGEAPVREFAATMPLVVRLGMKTPVGQSFLKAYPFEEAYFREKALRFREAVSMPLMLLGGINRLATMEQAMAEGFDFVAMGRALLREPDLVDRLQSGRATAGVCIHCNRCMPTIYSGTRCPVIAPEPA
>NC_008699.1|WP_011753917.1|454354_454762_+|hypothetical-protein
MSGDRRSGPHQVLLALYALFTLAAGARSIVQLTTQYDEAPVAYWLSLGAAVTYALGWFAIRQASAGHTGFASVMLRVELGGVVGVGTLSLAVRDWFPDASVWSDYGIGYGFVPAALPVAGLLWLRRQKRPALAAD
>NC_008699.1|WP_083768051.1|454001_454358_+|hypothetical-protein
MPSVSTQITWIVVGYAALVAVLAVVAARRGERPGWLDQMAWMLEVLLLVRALAGLGPLLGDDRPDSTSTYVGYLFASVCVLPIAMRSVAGDRAAWSSAVVAVAAVAVGVVAVRLQMTA
>NC_008699.1|WP_083768252.1|453118_454003_-|putative-protein-N(5)-glutamine-methyltransferase
MAASSTMAGPAPDDALVATLRAAGCVFAEDEAALLAREAGDEAALAAMVARRVAGEPLEQVLGFAEFLGLRVAVEPGVFVPRLRTTLLARRAIRALEPGDLAVDLCCGTGAIGVALLAAVPGAEVHAADIDPAAVRCARRNLPPDRVHEGDLYDALPGELRGRVAVVVANAPYVPTGAIATMPPEARDHEHRVALDGGADGLEVARRVIAGARPWLAPGGRVLVETSAAQRDLAAAHVVAAGLDVTVASAADVDGNVVIGRLHPERLSPERLSPEQLSPGQLSPGQLSPGRPRC
>NC_008699.1|WP_011753914.1|452286_453144_+|SDR-family-oxidoreductase
MSIVITGATGHLGRLVVEALLARGAEGIVATGRSVERLADLADRGVRVERLDFDDVPESVDWLGAGDVLLLVSGSEVGQRLPQHRAVVDLAVRAGVRRIAYTSAPAADDTTLAVAPEHAATEAMIRESGLPFTFLRNGWYTENYLPTFAQARESGLVIGSAGEGRVASAPRSDFAEAAAVVLTTDGHEGAVYELFGDAAWTYGELAATFADVLGREVTYRSLTPEAHREALLAAGLDEGTAGFVVALDQDIAAGLLGLSTGHLAKLLGRPTVPLRDTVSTWAAQD
>NC_008699.1|WP_140403800.1|451815_452208_-|winged-helix-turn-helix-transcriptional-regulator
MTLKWGTHLRVRFGVVPFVRDLQLDTDCPDTRLLVEHVTSKWGVLVLLTLDDRTLRWSELKREIAGVSEKMLIQTLQVLEADGLVRRTALPVVPPHVEYSLTDDGRAAAAHLAPLVRWAQARVGPRVAVS
>NC_008699.1|WP_011753912.1|450722_451823_+|endonuclease/exonuclease/phosphatase
MVRRVRLGRRDASRRARRWAGPPPLLLVATLIGFLVAPLVGHQPEPPPAARIAAHVTAPGARDSVLTASPTHPRAVADRPPRQRVLSAAPSRAGHAAGAGLRPVRLKRVHIGVASMNMYRKLSPAQAAHDARRLTRRPGLDVVGWQEADRFGRVLHSLPGWDTKTFPFGRRNSEIAVSWRRSEFALVSARQRQVAQGVSWRDGRYPFGNRMVGVVTLRHRDTGRLLTVVDAHLPQAIEDLSRPGRWTPTINAYRARNQLARIATTWRSAPGRWVVGTGDYNFDARADARHRPRGGPRRALADTAVSSYQALGADVAPTFPSNGRRIDYVYVDRAAYRAEQMRFTGQWVVGGFASDHNALVTRLVLS
>NC_008699.1|WP_140403786.1|450124_450643_+|ribonuclease-HI
MTDDGSQPPLCEGAPVPPRTRVKRPPRPAMPVPEGAREVFTDGACSGNPGPGGWAWALDTAVYASGREAPSTNQRMEIRAALEAVRSLDGPLLVVSDSTYVVHCFRDLWWQGWLDRDWVSSARKPVANRDLWEPLVGLVQDRGDVAFAWVKGHSGHVMNDFVDRLAVAATRA
>NC_008699.1|WP_011753910.1|449691_450126_-|hypothetical-protein
MGTEPLPTDLLGTWTLTRVVDDHLTGERRDVVGVTTLAVESPDRVRWSEEGTMTWAGRSVPVSRTLYVERAGETWEVTFSDGRPFHPWSVGHRVGHPCGADHYDGLIEVGPEGWSVEWRATGPEKDYVMTTVHSDRRAARRSSD
>NC_008699.1|WP_041546110.1|449485_449665_+|hypothetical-protein
MIDLSALEPFAIAFLVVGVVAAVVAAATLVAVVAEVRRVARPALAVVTAEPAATAGRAA
>NC_008699.1|WP_011753919.1|456144_457266_+|diacylglycerol-kinase
MVSTGSATERTPPRPPLRVVVWSTGTVGRHAIAGIDAHPDLELVGVWVSNPDKAGKDAGELAGLGRELGVCATTDKQQLLALRPDAIVHTAMTDDRVFEAIDDLVDFLEAGVNVTSSGPVLLQWPEQILPPELMERITKAGERTGASLHVNGIDPGFANDVLPLTLTSLSQRIDEVRVMEICDYSTYYQPVVMNDLFGFGKPMDQPGFLFAPGVLSMAWGSVVRQLAAGLGITLDEPLTEDVDRRPAEVDTTSVSGDVAAGTMGAVRFQVIGKVDGVPRVVLDHITRTAPDQVPEWPTPPDGDGCYRVVVTGEPFLQLDLTHHGENGDHNVSGMIVTAQRIVNAVPAVVASPGGLVTALDLPLVTGTGLVSRA
>NC_008699.1|WP_011753920.1|457321_458134_+|SDR-family-oxidoreductase
MILDRFSTEGQVAIVTGAGRGLGAATAVALAEAGSDVLISARTERQLDQVAERIRATGRRALVVAADLSDLDAVAGLAQTAYDELGRLDTVVNNVGGTFPNAFLDTSNEFLNEAFAFNVTTAHALTRAAVPLMLRDAGSVADAQKSVVTISSMMGRTADRGFIAYGTAKAALAHWTRMAAQDLAPRIRVNGIYVGSIMTSALEYVAGRPELMSQLETKTPLGRVGEPEDIAAGVVYLASRAGQYVTGKLLEIDGGIQQPTLDLGFPDVGS
>NC_008699.1|WP_011753921.1|458143_459244_+|MBL-fold-metallo-hydrolase
MTPSTSPASTPTAFAVSPDSGEHWSKAGAWQVADGIHRIPLPLPMDGLKAINVYVIESADGLTLIDGGWAIDVARDLLERCLRQVGYGFGDIRRFLVTHVHRDHFTLATVLGHEYGADVALGLGEKPALDLLNDRLLDESPFLDVLRTAGANAIADLWAAGGERPDPAMWLLPDTWLEGDHEIEVGVRTLDAVHTPGHTPGHYVFAEQAAGLLFAGDHVLPTITPSIGFTVPPTPDPLGDFMASLTKVRALPDLKVLPAHGPVAPSSHARADELLSFHDRRLEQSLAAIAEEPGTGFTVAHQLAWTRHEKAYDELDLFSQGMAAMEIKAHLELLVARGQATRADTPEGVLFSAVPAGAPGEDTLSG
>NC_008699.1|WP_011753922.1|459233_459677_-|GNAT-family-N-acetyltransferase
MITITAGPFTALDAPTAYAVWRLRQDVFVVEQECPYPDLDGRDDEPDTRHVLLRDDDTLLGYARVLDEERDGQAVWRIGRVVLDRAVRGQGLADPLVQTALQVCKDRDVVLDAQSPLAPWYATFGFEVSGPEFLEDGIPHTPMRLSR
>NC_008699.1|WP_011753923.1|459673_460591_-|alpha/beta-hydrolase
MSPSRRHEALAWVVPRLRRSRDLGTPEAERARIERWHARLARRLPTRVTPGFAKRFSVVTEVLTGRSGEFASYVVTPRGTDPRRTVVYLHGGGYVAPIDPFHVRYLCRLATDLHARIVLPDYPLAPEHTWRDSHAAIADLTGRWVGDSDQLVLAGDSAGGGYALAIAQTLRDRGGPQPARLLLHSPWVDLTTATPETESFTVRDPWLFLGKLQAYAAWWAGSTEDLGRPEVSPALAELGGLPPALMFCGTRDTLTPGCRLLARRAEQADWDLTYVEVHDLIHVYPLLPFIPEAREARRRTMEFLR
>NC_008699.1|WP_011753924.1|460687_461275_+|carboxymuconolactone-decarboxylase-family-protein
MPSTFRIPKATITGLYGKVVSAYARRTFGEIPDGLYVYFHHKPLMRAVVGFEGKVAKWGALDPTLKSYAELASAGTIGCSWCLDFGYFKAHDEGVDLAKVSEVPRWRESDVFTPLEREVLEYAEAMTATPPTVTDAMVARLVEQLGTPAVVELTQIVALENMRSRFNSAAGLQSQGYSDVCELPLAVPSGDVRPA
>NC_008699.1|WP_011753925.1|461271_462150_+|RNA-polymerase-sigma-70-factor
MNATDSTDVFVDHRNLLFTVAYEMLGSAADAEDVLQETWLRWVEVDREEVREARAYLVRIATRLALNRMRTNARRRESYVGPWLPEPLLTTPDVAEDVELADSVSLAMLTLLETLGPTERAVFVLREVFDFGYDEIAAAVDKTPAAVRQIAHRARGHVAERRPRAEATRSEREHVMATFLAAVATGDIQSLMDVLAPDVVLVTDGGGVKKAALRPILGRDKVVRFLGAVSEGLDAVADVVVVNGAPALRIVLDGELDTVASMVVEDGLVTGLYVVRNPAKLARLDAVVTLTR
>NC_008699.1|WP_011753926.1|462412_463492_+|thiamine-ABC-transporter-substrate-binding-protein
MRPIHALAPLAPLVALALAATGCSTIGNGSSGDESTASPGGEPGRVVLVTHESFSLPKPLIKQFEQQSGYDLVVRASGDAGILTNKLVLTKGDPLGDVAFGIDNTFASRALDEGVFAPYDAPLPDGADQYRLPGDDEHDLTPIDNASVCVNVDDTWFADHHLAPPKTLDDLAAPEYQGLFVTPGAATSSPGLAFLLSTIAAYGEDGWQDYWARLMENGTKLTAGWSDAYEVDFTQGGGQGDRPIVLSYDSSPAFTVADGESSTSALLDTCFRQVEYAGVLDGAANPAGAEQLVDFLLSPEVQAALPESMYVFPVDSSVQLPKEWARFAKQPSDPFSVDPASIDEHRDEWLREWTDVTSR
>NC_008699.1|WP_011753927.1|463525_465160_+|iron-ABC-transporter-permease
MRRSLELVGLAALPLAVLGVFFLLPVSGMVSEGFVTDGRFDPGGVLEVLGRPRVHRVLWFTVWSSTVATLLAVLLGLPVAHLLHRRRFWGRRALRSLLLVPFVLPTVVVGVAFRELIGEAGPLGFLGLDGSAVAIVAGLVFFNVAVVIRAVGAAWESLDPRPAEAAAALGAGPAHVFRTVTLPALRPAIVSAASVVFLFCATAFGVVLTLGGLRYSSVETEIYLLTTNLLDLQAAAALSILQLLAITALLVVTGRLRAVPDPALARSTRRPPRPAPGDWPGLVATGLVLLLVGAPVAALVAGSLRVGDAWSLGNYRALTGEGTQHALLASATDALVTSLRTAVDATWMSLSLGVLVTVVVTRRSRTRGERRARGLLDGLFMLPLGVSAVTLGFGFLITLDRPPLDLRDSPLLVPIAQALVALPLVVRTLVPVLGGIDDRQRQAAASLGAGPLRTFATVDLPAMWRPLTAAAGFAFAVSLGEFGATSFLAREDHPTLPIVIYHLIGHPGAMNYGMALAASVVLATTTALVMLAVDRLRVPSVGAF
>NC_008699.1|WP_011753928.1|465159_466158_+|ABC-transporter-ATP-binding-protein
MLALDHLSVSYDGVPAVVDATLELADGHVLAVLGPSGSGKSTLLRAVAGLEPAVAGRICWDGADLAHVPTHKRGFALMFQDGQLFNHLTVARNIGYALRLRRTPRAAERVAELLALVGLEGYAERLPATLSGGERQRVALARSLAVAPRLLLLDEPLSALDAGLRERLAVDLREILRAAGTTALMVTHDQEEAFAVADRLAVMRAGRIVQQGEIAEVWRAPADPETALFLGYARVLEGSAAAALLQAAGLPVAPAVAVRRSALVVADGAEAGPLRGAVVSARATPELIRLVVDVDTIGEVDAVARLGTHPGPGDPVRLSVDPSRLAPTPTGR

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Crispr_ID: NC_008699_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_10

482126-482210

Orphan

Consensus_repeat	Method
TTCCCCGGTGAACCGGGGAAACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_10

>merge|NC_008699|10|482126-482210|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCAGAACTGTTGACCCGAAGTTTCGGCCCAGAAGTTCCAACTTCCCCGGTGAACCGGGGAAACC

>NC_008699|10|10|482126-482210|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACC	AGAACTGTTGACCCGAAGTTTCGGCCCAGAAGTTCCAAC
TTCCCCGGTGAACCGGGGAAACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_041547066.1\|477977_478790_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
NC_008699.1\|WP_011753935.1\|473579_474293_+\|Ig-like-domain-repeat-protein	unknown	unknown	gnl\|CDD\|379864
NC_008699.1\|WP_011753949.1\|485731_486844_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NC_008699.1\|WP_041546116.1\|489136_490051_+\|DUF2520-domain-containing-protein	unknown	unknown	gnl\|CDD\|227782
NC_008699.1\|WP_011753951.1\|487978_488893_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213815
NC_008699.1\|WP_011753943.1\|480243_480849_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173412
NC_008699.1\|WP_049774199.1\|484788_485739_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270324
NC_008699.1\|WP_041546114.1\|482220_483207_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213262
NC_008699.1\|WP_011753953.1\|490047_491052_+\|pantoate--beta-alanine-ligase	unknown	unknown	gnl\|CDD\|376824
NC_008699.1\|WP_011753942.1\|479742_480234_+\|DUF3180-domain-containing-protein	unknown	unknown	gnl\|CDD\|378650
NC_008699.1\|WP_041546119.1\|491051_491471_+\|aspartate-1-decarboxylase	unknown	unknown	gnl\|CDD\|376751
NC_008699.1\|WP_140403801.1\|483971_484736_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224095
NC_008699.1\|WP_011753941.1\|479165_479735_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|223872
NC_008699.1\|WP_011753940.1\|478786_479173_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
NC_008699.1\|WP_011753950.1\|486893_487982_+\|sulfotransferase-family-protein	unknown	unknown	gnl\|CDD\|226081
NC_008699.1\|WP_011753937.1\|475119_477165_+\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
NC_008699.1\|WP_041547065.1\|477316_477922_+\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472
NC_008699.1\|WP_041547068.1\|483312_483966_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NC_008699.1\|WP_011753936.1\|474308_474860_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NC_008699.1\|WP_041547067.1\|481006_482113_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_041547066.1\|477977_478790_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	3.47102e-106
NC_008699.1\|WP_011753935.1\|473579_474293_+\|Ig-like-domain-repeat-protein	gnl\|CDD\|379864	pfam16640, Big_3_5, Bacterial Ig-like domain (group 3). This family consists of bacterial domains with an Ig-like fold.	1.34405e-06
NC_008699.1\|WP_011753949.1\|485731_486844_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	3.43205e-41
NC_008699.1\|WP_041546116.1\|489136_490051_+\|DUF2520-domain-containing-protein	gnl\|CDD\|227782	COG5495, COG5495, Uncharacterized conserved protein [Function unknown].	3.46748e-41
NC_008699.1\|WP_011753951.1\|487978_488893_+\|hypothetical-protein	gnl\|CDD\|213815	TIGR03469, HpnB, hopene-associated glycosyltransferase HpnB. This family of genes include a glycosyl transferase, group 2 domain (pfam00535) which are responsible, generally for the transfer of nucleotide-diphosphate sugars to substrates such as polysaccharides and lipids. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. Indeed, the members of this family appear to never be found in a genome lacking squalene-hopene cyclase (SHC), although not all genomes encoding SHC have this glycosyl transferase. In the organism Zymomonas mobilis the linkage of this gene to hopanoid biosynthesis has been noted and the gene named HpnB. Hopanoids are known to feature polar glycosyl head groups in many organisms.	2.22564e-06
NC_008699.1\|WP_011753943.1\|480243_480849_+\|hypothetical-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	8.62907e-06
NC_008699.1\|WP_049774199.1\|484788_485739_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270324	cd13606, PBP2_ProX_like, Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold. This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.87006e-75
NC_008699.1\|WP_041546114.1\|482220_483207_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213262	cd03295, ABC_OpuCA_Osmoprotection, ATP-binding cassette domain of the osmoprotectant transporter. OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	1.5411e-135
NC_008699.1\|WP_011753953.1\|490047_491052_+\|pantoate--beta-alanine-ligase	gnl\|CDD\|376824	pfam02569, Pantoate_ligase, Pantoate-beta-alanine ligase. Pantoate-beta-alanine ligase, also know as pantothenate synthase, (EC:6.3.2.1) catalyzes the formation of pantothenate from pantoate and alanine.	1.35349e-149
NC_008699.1\|WP_011753942.1\|479742_480234_+\|DUF3180-domain-containing-protein	gnl\|CDD\|378650	pfam11377, DUF3180, Protein of unknown function (DUF3180). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	7.70768e-21
NC_008699.1\|WP_041546119.1\|491051_491471_+\|aspartate-1-decarboxylase	gnl\|CDD\|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	2.44036e-80
NC_008699.1\|WP_140403801.1\|483971_484736_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	1.11363e-44
NC_008699.1\|WP_011753941.1\|479165_479735_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	2.51022e-51
NC_008699.1\|WP_011753940.1\|478786_479173_+\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	1.21815e-43
NC_008699.1\|WP_011753950.1\|486893_487982_+\|sulfotransferase-family-protein	gnl\|CDD\|226081	COG3551, COG3551, Uncharacterized protein conserved in bacteria [Function unknown].	9.35132e-19
NC_008699.1\|WP_011753937.1\|475119_477165_+\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_008699.1\|WP_041547065.1\|477316_477922_+\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	3.11148e-114
NC_008699.1\|WP_041547068.1\|483312_483966_+\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	9.80126e-49
NC_008699.1\|WP_011753936.1\|474308_474860_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	6.2621e-86
NC_008699.1\|WP_041547067.1\|481006_482113_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.33067e-07

>NC_008699.1|WP_041547067.1|481006_482113_+|GNAT-family-N-acetyltransferase
MLGDLPGLPSGWTIGTPDPSDRFDVARLTHLLRAHERHARGWAGSGVDDVMVEVSEHGLRMRENVVIRDEDGDIHAWGSVHDRSVGRMLFVHIVQRDLPDDPDGSIADSCSDLLVEWAEAQARCVGSARGLAVQQIDTGAFAGDERQARWLAGSGFEKVRTWWQMSRPVTPDEEGLVATPDHWTDRGVVFRLVRRTGDGMPDEGDLHEVHEVLEGAFVDHFNSSEETFEEFVHRLREDPGHRWDHWWLAELVEDGEDGEDGEDGEDGEDGEDGVRRPVGALIGTASEDATGPDGSYVSYLGVLEAARGRGVATGLLRTIIADAAARGRNRVGLEVDADSPTGATGLYTSMGWVTKYVTESWHRDIPVA
>NC_008699.1|WP_011753943.1|480243_480849_+|hypothetical-protein
MASSPAPASRRRQRSTRLTVAVVLLVLAALVVAAAAATGSTVLITLAAVLGVALGAAATRITHSELALTRREAARDRAEQARAYRTLTAERTAENAAFAESMRTRMARQQDALRELEEALTAAQGRAAEATRKLNAEARRADAAERDSRQLEEGLAGAEQRAAEAIVRVAELEQELDVVRAELDVVTQAWHAAEAGQRKHA
>NC_008699.1|WP_011753942.1|479742_480234_+|DUF3180-domain-containing-protein
MSAGPSGEEPQPTGRLRPTSGGALTAWAVAGLVGGWLLHPAAERVRDTAPIVTWAQPLALVLVAAILGATAYLTWRTVHVQQQRLEPQRAVNRLVLARSCALVGALVAGGYLGYAVSWIGVDTELATQRAWRSAVAAAAGVGIVVTSVLLERACRVRSDDEDT
>NC_008699.1|WP_011753941.1|479165_479735_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MTETPNPNIIDADTLTGEMRPIRRAVLALGSNLGERMGNLQGALNALADTPDVWITAVSPVYETDPVDCPPEAKTFLNAVVLIDTTLAASRLMDRALAIEDAFERERGEQRNAPRTLDVDLIVVGDRRSNEEFLRLPHPRAAERAFVLRPWFDVDPAAEVPDRGPVADLLDGTDQSGLKLRDDLVLEIQ
>NC_008699.1|WP_011753940.1|478786_479173_+|dihydroneopterin-aldolase
MTERPTDELSVTGIACYGHHGVFDFERREGQTFVVDLVLGVDTAPAAASDDLQDTVDYGSLVASVQAAVEKDPVDLIETLAQRIAGVCLLDGRVEWARVTVHKPDAPIEATFADVTLTITRRREGTRD
>NC_008699.1|WP_041547066.1|477977_478790_+|dihydropteroate-synthase
MGVVNVTPDSFSDGGRWLEPRDAIAHGRDLLADGADILDIGGESTRPGATRPLVEEELGRVVPVITALAAEGAVVSVDTMRAEVAEAALAAGATVVNDVSGGLADPRILEVVAASGAAYVAMHWRAHADHMRDFAVYDGPGGVVGAVCDELTARVRAMTAAGIAREQVILDPGLGFAKRAEHNWELLRRIDELAALGYPLLVGASRKSFLGRLLVDRGGVPRAVDQREHANAAITLHLARHAVWGVRVHDVRASRDALRVAEQLSEEGST
>NC_008699.1|WP_041547065.1|477316_477922_+|GTP-cyclohydrolase-I-FolE
MSDSTLPGGRPAPAFDLARAEAAVRELLIAIGEDPEREGLQETPARVARAYAELTAGLRMEPEDVLTTTFDIGHDEMVLVRDIELWSMCEHHLVPFTGVAHVGYIPATSGKITGLSKLARLVDVYAKRPQVQERLTTQVADALTRLLEARGVIVVIEAEHLCMTMRGVKKAGARTITSAVRGTMRTNPTTRAEAMALIHRR
>NC_008699.1|WP_011753937.1|475119_477165_+|ATP-dependent-zinc-metalloprotease-FtsH
MKRIFKGPWLWIVLAVVGVLLALQYLAPNRGGEEVDASKMQDLISSGEIKELTFVDGGEQQIKATLDNGDKVTAFWLDGTQAELDSQVQDQVDAGKIDSYTVEVPKPSLLGSILATLLPFALIILLFLFLMNQVQGGGGRGVMQFAKSRAKLISKDMPKTTFGDVAGCEEAIEELGEIKEFLQEPAKFQAVGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFEQAKENAPAIVFIDEIDAVGRHRGAGMGGGHDEREQTLNQLLVEMDGFDVRGGVILIAATNRPDVLDPALLRPGRFDRQIQVDAPDLNGRHMILKVHSRGKPMSQDIDLLSVARRTPGFTGADLANVLNEAALLTARSNQKLITNANLDEAIDRVIAGPQRRTRLMSEKEKLITAYHEGGHALVAAALPGTDPVHKITILPRGRALGYTMVLPDEDKYSQTRSQMLDSLAYMLGGRAAEEMVFHDPTTGAGNDIEKATNLARAMVTQYGMTERLGAIKLGESNSEPFLGRDLGHARNYSEDVAAIVDEETKKLLANAHQEAFEILEENRDVLDALVLELVEKETLDKQQVAEVFAPLRRRSERPAWTGSPERNPSAIPPVEIPQWIRDRAAANGHSKEEGEAGPVLTPPGSGGDVHGDPGVGGAETPPGLPPH
>NC_008699.1|WP_011753936.1|474308_474860_+|hypoxanthine-phosphoribosyltransferase
MHASDVENDLVNVLFTEEQIQQRLAELAKDIEADYEGKDLLIVGILRGAVMVMADLARSFTRHLEMDWMAVSSYGSGTKSSGVVRILKDLDTDISGRHVVIVDEIIDTGLTLSWLTSNLSSRSPASVEICTLLRKPDALTMPVEVKYVGWDIPNEFVVGYGLDYRERYRNLRDIGTLAPHVYS
>NC_008699.1|WP_011753935.1|473579_474293_+|Ig-like-domain-repeat-protein
MSHRRTFAAAVALLAAAVIAPQALPASASPAGRAVTAQRAGQALIQGVVVDQAGRYVDDVEVQATKADGTPAASAITYASDREDGPQHGYFFLEVTRGTYTLTFSRDGYRTLVLDDLQIERARQKLSLGEVEIQKKLAESKTEASLVRRTITTKQNGEVVVTVSARGVKPTGDVEIREGRTVVGEDGLRARDNGQVTIELDRLPRGTHELKAYYLGSPDLKVSASTSFTLTVTRGRH
>NC_008699.1|WP_041546114.1|482220_483207_-|ATP-binding-cassette-domain-containing-protein
MIRLSGVGKTYDDGTVAVHALDLEVERGELVCLVGPSGCGKSTTLKMINRLIEPTTGTIEIDGRDVTGQDPVRLRRGIGYVIQEVGLFPHQKIIANVMTVPLLYGESRATARERARELLELVGLDPATYAERYPTQLSGGQQQRVGVARALAAKPPVLLMDEPFGAVDPLVRLRLQDEFLRLQRELGVTVVFVTHDIDEAVRLGDRVAVFATGGRLAQYDTPARLLGRPADDFVAEFVGSTSGLRRLDVTPLDPAHLEPMDGVTAGDLGAAIDVDSTLGHALAVLLRGDAGMVGVREGARFVGVLTPNGIHRALRAALAEMAEVASAG
>NC_008699.1|WP_041547068.1|483312_483966_+|ABC-transporter-permease
MTNEWFCGQYLGDYRHELVDATTQHLVITVVSVIAGVVIAFPLALLARRLPALETSVLGVTTAVYTIPSLALFPLLVPFTGLSATTVVIGLALYALTILVRSMLEGLRSVPEEVRESAVGLGYGATRLLVLVELPLALPVIMAGLRVATVSTVALTTVGSLVAYGGLGNLIKDGVTTNFRAELMTASLLCVLLAVVLDALIVGAQWLLTPWSRGARG
>NC_008699.1|WP_140403801.1|483971_484736_+|ABC-transporter-permease-subunit
MTVLADAWDYLTTAGSWTGDGGMVELLLQQLLLSFTSLALAAAVGLPVALWLGHLGRGGFLAINVTNIGRAVPTFALLALLVTADWPGTGTLGPYGRAGLATIIALTLFALPPIITSSYVGVREVSPAVKQAADGMGMTGRQRFFRVELPLAAPLVLLGLRLALVQVWATATIAALVAGPGLGRVITDGFYRTNYGKGVAGAVVVAVVALLLELLAALGQRVLDPTARASSPKRHQGMSVDAPRVTEAADAVGR
>NC_008699.1|WP_049774199.1|484788_485739_+|ABC-transporter-substrate-binding-protein
MQVRRSLAAALAVGSLFLATACADDDLDSKQADDATPSATTDQGPVRIAGQSFTEAAIVAAMYDELLTAAGYDTDVKLVDTRDAYMATFPDSVDVVPEYVGGIVNFLNARENGAKAEPFTAGDGAELVDQGKSLLDAAGIALLDQSAATDTNAFFVTKDFSESEGVTKLSDLEGRSVKLAAAPDCEGRLDCEGGLVDQYGIDVTEVLPLGYASNDTYQSVISGESELGETSTTDGTLESQGLVVLEDDKQIQPAQNLVPAVSSAFLEQHPDIADVLNGLMAALTTEKLTELNGAVAVDRDKPEDVAHQFLVDEGLI
>NC_008699.1|WP_011753949.1|485731_486844_-|glycosyltransferase-family-2-protein
MKFGRRRPLVSVVVPVYDVAAYLPEALDSVLAQSHRNLEVVVVDDGSPDASGVIADEYAGRDPRIRVVHTANRGLGAARNEGIRHATGDLLAFADSDDVVPRDAYAVLVRHLERTGSEFVTGSVARWEAGVLTELPWMRRLHRDRGAFTLEEHPELLGDVFAWNKLFRRSFWDRAELAWPEGIRYEDQPTTTRAFVAAERFGVVPEVVYHWRIRHDGTSITQQRASLADLRDRWETKRMALASVASLGSEQVDAVFHDRVLAGDLHRYFAEIPGCSDQWWDLLVAGVREFWGDRSLVHSGLPPVHRLTGWLVEQGRREEAELVMRYVAALGGPVPQVDAPHGPRIDVPGLDPTGVDPAALALRDFEVRAR
>NC_008699.1|WP_011753950.1|486893_487982_+|sulfotransferase-family-protein
MPADPSDVDPADYPRKVLFVAGAGRSGTSTMAGLMQIMGLHVPQPEVVADETNPKGFGEPAWVVEHHDRLLKEAGVQVSDARPEAWFETGRVSTREPERIRTAEWLDGHFAVNPELVVKDPRLSWFLSLWRVAAVRTGATPVFATMLRPPAEVVGSKQNYYQNRLGSAHLAASWLNMLLHTERATRESVVDGGRVFVRYADLLDDWTRVVMHAGERLGLEHVMHAKSEAIRNGHRFVDPSLRRMNQTLEDLALPPRLHELTAETWEELNKLAEPDGDTPAVHEALDQLREGYVELYEEAAAISRSSVVAAEQRVRKQLKGGGGSRPAPAAPADPADRIPHGVRAAIPAPVRRGLRKAMGRSR
>NC_008699.1|WP_011753951.1|487978_488893_+|hypothetical-protein
MTAHLGATGLANLEGHTDFDITWPWLRPGGLRPGSTAVLRVKNEAPSLPFVLPPLLRACEFVLLVDNGSDDGTPDVARETAERAGRADRLTVTSYPFAVARAGAEHLAQHELSVHSLAYFYNWCFSQVTTRYSWKWDGDMVLTTEGEVSIADLGWQVGDVQSIIRVPRHGLYLESEAKGYLDLGWRNAEEWGFPIGPDFVYTKAFEWEIRTTPVGVRSIGLPHGLCVELKYLDGEEFAHWTDPESFATSWRNRRKRREWEVFHALKEGRVPPGVHEITAPAGVHIVDHVTHDWLPHAPRPLQVG
>NC_008699.1|WP_041546116.1|489136_490051_+|DUF2520-domain-containing-protein
MTHLSANLRVGVVGAGRVGAVVAAALGAAGHHVVAAAGESDASRARIADLLPGTRTAKPTDVARSCDLLLLTVPDDMLGNVVTVLSDSGAIRPGQYVVHTSGRHGLAVLEPAARAGAHPVAMHPAMTFTGTALDLDRLPGCVYGLTAEPSERVFTEGLVADLRGRPTWVPEEMRTLYHGGLAHGANHLVTLVSQAMELLAAAGCDHPAGTLRPLLTAALDNALEQGDSALTGPIVRGDVNTVRAHLADIATNAPHTLPSYVALARDTLDRVVTDGRVLPIRAAAIKRALEQAEQAAPRTTAPRR
>NC_008699.1|WP_011753953.1|490047_491052_+|pantoate--beta-alanine-ligase
MSSAPVLAHTREELATLLAAARARGEQVGLVPTMGALHEGHASLVRAARERVTDDGRMGPVVVSVFVNPLQFGANEDLDRYPRTLEADLEVCAREGADIVFAPSVDEVYPGGPPQVTVRPGPLGKILEGKVRPGHFRGVLTVVAKLFGLVRPDVAVFGQKDYQQLALIRRMVLDLALGVEIVAAETVREDDGLALSSRNRYLEPEQREQAVALSRALLAAQENAGYGAEVALDEARAELRAAPGVDLDYLVITDPDLDELPAVVPPGTPARILVAARVGGTRLIDNLPLMLGTRGPAGEASPPNRERSEPGSAEQNKSPGEARTTPSGTSEASE
>NC_008699.1|WP_041546119.1|491051_491471_+|aspartate-1-decarboxylase
MLRTMMKSKIHRATVTQADLHYVGSVTVDEDLLDAADLLPGELVHIVDIDNGARLETYTIAGERGSGVIGINGAAARLVHPGDLVILIAYGQMEDVEAKGFEPHVVFVDADNRVVSTGSDPADAPAGSGLLRGDRPAGR

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Crispr_ID: NC_008699_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_11

520013-520098

Orphan

Consensus_repeat	Method
CGGTTTCCCCGGTTCACCGGGGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_11

>merge|NC_008699|11|520013-520098|CRISPRCasFinder
CGGTTTCCCCGGTTCACCGGGGAAGTTGCCACTCCGGGGCCGAAACTTCGGGTCAACAGTTCCGGTTTCCCCGGTTCACCGGGGAA

>NC_008699|11|11|520013-520098|CRISPRCasFinder
CGGTTTCCCCGGTTCACCGGGGAA	GTTGCCACTCCGGGGCCGAAACTTCGGGTCAACAGTTC
CGGTTTCCCCGGTTCACCGGGGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_041546126.1\|521043_522582_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341259
NC_008699.1\|WP_011753991.1\|530332_531670_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607
NC_008699.1\|WP_011753981.1\|519077_519878_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|131997
NC_008699.1\|WP_011753973.1\|510530_511481_+\|proline-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223580
NC_008699.1\|WP_008356322.1\|515311_515413_+\|AURKAIP1/COX24-domain-containing-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753990.1\|528933_530103_-\|lytic-murein-transglycosylase	unknown	unknown	gnl\|CDD\|225501
NC_008699.1\|WP_011753988.1\|526009_527668_+\|uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|223086
NC_008699.1\|WP_011753989.1\|527692_528694_+\|porphobilinogen-synthase	unknown	unknown	gnl\|CDD\|236450
NC_008699.1\|WP_011753980.1\|517792_518947_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753986.1\|523684_524977_+\|glutamyl-tRNA-reductase	unknown	unknown	gnl\|CDD\|234592
NC_008699.1\|WP_140403803.1\|524985_525918_+\|hydroxymethylbilane-synthase	unknown	unknown	gnl\|CDD\|234612
NC_008699.1\|WP_011753992.1\|531682_532363_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NC_008699.1\|WP_011753977.1\|514975_515179_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NC_008699.1\|WP_011753984.1\|522578_522824_+\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|368604
NC_008699.1\|WP_041546128.1\|523025_523688_+\|redox-sensing-transcriptional-repressor-Rex	unknown	unknown	gnl\|CDD\|235486
NC_008699.1\|WP_011753975.1\|512431_513400_-\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|234866
NC_008699.1\|WP_011753974.1\|511591_512395_+\|pyrroline-5-carboxylate-reductase	unknown	unknown	gnl\|CDD\|237008
NC_008699.1\|WP_011753978.1\|515439_516519_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187551
NC_008699.1\|WP_011753976.1\|513594_514779_+\|acetoin-utilization-protein-AcuC	unknown	unknown	gnl\|CDD\|212520
NC_008699.1\|WP_011753979.1\|516511_517639_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153249

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_041546126.1\|521043_522582_+\|AMP-binding-protein	gnl\|CDD\|341259	cd05936, FC-FACS_FadD_like, Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD. This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	2.13128e-147
NC_008699.1\|WP_011753991.1\|530332_531670_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NC_008699.1\|WP_011753981.1\|519077_519878_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|131997	TIGR02952, RNA_polymerase_sigma-70_factor_ECF_subfamily, RNA polymerase sigma-70 factor, TIGR02952 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family. This family is found in a limited number of Gram-positive bacterial lineages.	1.4954e-54
NC_008699.1\|WP_011753973.1\|510530_511481_+\|proline-dehydrogenase-family-protein	gnl\|CDD\|223580	COG0506, PutA, Proline dehydrogenase [Amino acid transport and metabolism].	4.90521e-53
NC_008699.1\|WP_011753989.1\|527692_528694_+\|porphobilinogen-synthase	gnl\|CDD\|236450	PRK09283, PRK09283, porphobilinogen synthase.	0
NC_008699.1\|WP_011753988.1\|526009_527668_+\|uroporphyrinogen-III-synthase	gnl\|CDD\|223086	COG0007, CysG, Uroporphyrinogen-III methylase [Coenzyme metabolism].	4.45999e-63
NC_008699.1\|WP_011753990.1\|528933_530103_-\|lytic-murein-transglycosylase	gnl\|CDD\|225501	COG2951, MltB, Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane].	2.47092e-22
NC_008699.1\|WP_011753986.1\|523684_524977_+\|glutamyl-tRNA-reductase	gnl\|CDD\|234592	PRK00045, hemA, glutamyl-tRNA reductase; Reviewed.	1.51658e-146
NC_008699.1\|WP_140403803.1\|524985_525918_+\|hydroxymethylbilane-synthase	gnl\|CDD\|234612	PRK00072, hemC, porphobilinogen deaminase; Reviewed.	3.7185e-132
NC_008699.1\|WP_011753977.1\|514975_515179_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	1.90142e-17
NC_008699.1\|WP_011753992.1\|531682_532363_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	2.87566e-42
NC_008699.1\|WP_041546128.1\|523025_523688_+\|redox-sensing-transcriptional-repressor-Rex	gnl\|CDD\|235486	PRK05472, PRK05472, redox-sensing transcriptional repressor Rex; Provisional.	1.50906e-112
NC_008699.1\|WP_011753984.1\|522578_522824_+\|glutaredoxin-family-protein	gnl\|CDD\|368604	pfam05768, DUF836, Glutaredoxin-like domain (DUF836). These proteins are related to the pfam00462 family.	1.23586e-21
NC_008699.1\|WP_011753978.1\|515439_516519_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.2876e-80
NC_008699.1\|WP_011753974.1\|511591_512395_+\|pyrroline-5-carboxylate-reductase	gnl\|CDD\|237008	PRK11880, PRK11880, pyrroline-5-carboxylate reductase; Reviewed.	4.35363e-103
NC_008699.1\|WP_011753975.1\|512431_513400_-\|tryptophan--tRNA-ligase	gnl\|CDD\|234866	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed.	1.27204e-149
NC_008699.1\|WP_011753976.1\|513594_514779_+\|acetoin-utilization-protein-AcuC	gnl\|CDD\|212520	cd09994, HDAC_AcuC_like, Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes. AcuC (Acetoin utilization protein) is a class I deacetylase found only in bacteria and is involved in post-translational control of the acetyl-coenzyme A synthetase (AcsA). Deacetylase AcuC works in coordination with deacetylase SrtN (class III), possibly to maintain AcsA in active (deacetylated) form and let the cell grow under low concentration of acetate. B. subtilis AcuC is a member of operon acuABC; this operon is repressed by the presence of glucose and does not show induction by acetoin; acetoin is a bacterial fermentation product that can be converted to acetate via the butanediol cycle in absence of other carbon sources. Inactivation of AcuC leads to slower growth and lower cell yield under low-acetate conditions in Bacillus subtilis. In general, Class I histone deacetylases (HDACs) are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase.	1.14229e-162
NC_008699.1\|WP_011753979.1\|516511_517639_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153249	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.	6.87312e-44

>NC_008699.1|WP_011753981.1|519077_519878_-|sigma-70-family-RNA-polymerase-sigma-factor
MSWEDTDVARGLDALRRLVAHVLVLEQPQLAGTPGMLATEAVASGRAEMRAKTRPKSGPGTGDGGPDGYGDAELATSSEEDEAERSRLIALVELARKGDADAFGLLYDHYQPSVYRFLFYRTRSGTLAEDLTSETFFRALRSMNNFRWQGKDFGAWLMTIARNLATDHFKAGRTRLELTTEDMGLHDDATEGPESMVLAGLTNELLLHALTELPPEQRDCLVMRFLQGMSIAETAAVLGRSDGAVKQLQLRGVRNLAKLMPEGIRD
>NC_008699.1|WP_011753980.1|517792_518947_-|hypothetical-protein
MTWGFTAQRRAEEFDARVEGASTYDVADPRDAELLALVGALRAVPEAQPRPEFVATLRERLMAEAATALVPDDVSRLTLPARRPTRERRLAAVVGGIVIVGASTSLAVASQSALPGDSLYPVKRAIEQAHTGLSVGEGSKGTTILANASDRLDEVDALTRQNHFGDEIRIADTLNTFTDQATQATDLLLADYAHTGEASSIAHLRDFAASSLTRLADLEPLVPAEARDELIRAAGVVTTIDTEAALRCGDCGGAGITSIPATLGAAAEVINVPKPPADAVTKGDRTRNGGKHGTKGAQGTGLPDVDPGEVGPGSILNPDGSGLQPGTTTSGGSDPIGDLANGLTGGDSPSDAPSVPVVTDVVDGVGGILQDVVDGVTGGLPKTP
>NC_008699.1|WP_011753979.1|516511_517639_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MGDAEIIPIGTRGRPGRGTGKHPSSAARGLATGARPPAAKAGRRTAGPASGSAPEPPARSDTRAERPATTTQDRAPLAGIPASDWLAAVQHGAREVFGEQWEPQLARFLAFLRRRITGDYVVDEYGFDQEITERFLMATLRPIAQKWFRIEVRGIENIPTEGGALVVSNHSGTIPVDGLMTLVSIYDHTGRFLRPLGADLVFRLPFVSSLARKSGATLACNEDAERMLHGGQLVGVWPEGFKGIGKAYSDRYKLQRFGRGGFVSAALRTGVPIIPLAVVGAEEIYPLVGNLPSLARALGLPYLPVTPFFPALGPLGLVPLPSKWLLEFGEPIRTDELDVGAADDPMLVFNVTDQVRETIQQTLYSLLMQRESVFK
>NC_008699.1|WP_011753978.1|515439_516519_+|NAD-dependent-epimerase/dehydratase-family-protein
MGSAGRVVLVTGVSRDLGRRFARALAADPSVDRVVGVDAVPPRGDIGEVSFVRADIRNPVIAKVIVKEDVDTVVHMSVISTPGSAGGRNTMKELNVIGTMQLLAACQKAPGLRTLVVKSSTTVYGASNRDPAMFTEDMEPRRVPRSGYAKDVAEVEGYVRGFARRRPDVSVTILRAANVIGPQVTSPLTSYFRLPVIPTVLGFDPRLQFLHEQDLLDVLRHAIAAEVAGTFNVAGAGILMLSQAVRRLQRPSVPLPPFAVGRVGSTLRSARVADFSPEQLGLLTYGRGVDTTRMRTELGFEPALTTAGAFADFAAPLPPTGGYADRLLARVAQGLPEPAPVPAPLPASAPAYPRGADRG
>NC_008699.1|WP_008356322.1|515311_515413_+|AURKAIP1/COX24-domain-containing-protein
MGSVIKKRRKRMAKKKHRKLLKKTRVQRRKLGK
>NC_008699.1|WP_011753977.1|514975_515179_+|helix-turn-helix-domain-containing-protein
MATNPGDSSSSKFLTVAEVAAMMRVSKMTVYRLVHNGELPAVRVGRSFRVQEKDVDEYLRKSFYSAG
>NC_008699.1|WP_011753976.1|513594_514779_+|acetoin-utilization-protein-AcuC
MPACQGPATVVFDPSLTAYDFGPTHPMSPLRVDLTIRLAEELGVLAGLRRVDAPVATDEVIATVHRPALIEAVRRAGTMPGILDEAHGLGTDDNPTFPDMHHAAAHIVGATVEAARQVWSGESLHAVNISGGLHHAMPERASGFCIYNDVAVGIQHLLDSGAKRVAYVDVDVHHGDGVEKVFWDDPRVLTISLHETGQMLFPGTGFPTDAGGPAARGTAVNVALPPGTGDGGWLRAYHAVVPPLVREFAPDVLVTQHGCDSHIEDPLAHLMLSVDGQRAAYLALHELAHEVCGGRWVATGGGGYALVEVVPRAWTHLLAIVAGRPLDPATETPEGWRRHVQTTLDQVAPHRMTDGRTPAYRDWIDGYDPEIWLDRAIHSTRMEVFPLHGLDPFP
>NC_008699.1|WP_011753975.1|512431_513400_-|tryptophan--tRNA-ligase
MHRQLSLLTPSGHLTLGNLLGALRPMAAAQRDASTPAACFYGIADLHAMTTPHEPARLRSLTHETATLLLAAGLEESTLFVQSRVPAHAQLAYLLECTASTGELNRMIQFKEKGRDQPTTRASLFTYPALMAADILLYRPRQVPVGADQRQHVELTRDLATRFNSTYGPVFTIPEITVPAAGARVMRLDDPTVKMGKSAAETPGVVRLLDPPDVVRRKVARAVTDSDTGPDAVRADPNKPGVTNLLEILTACGGSAEGISTYGALKKAVADAVIAELEPLQKRYADLAADPAHVTSVYEAGAARCREVTAPVLAAAQAAMGL
>NC_008699.1|WP_011753974.1|511591_512395_+|pyrroline-5-carboxylate-reductase
MSQTAILGAGVMGETLLSGLVRAGRRVDHLLVGEKRPERAQELEERYGVAVVGNAEAARKADTLALVVKPQDMGDLLEEIAGELRPGQLVVSLAAGITTAFIEARVPEGVAVVRVMPNTPALVDEGMAAVSPGSHCSEEHLAEAESLMASVGRVLRIPERQQDAVTAISGSGPAYIFFVVESMIEAGVHLGLPRATATDLVVQTVVGSAKMLRETGTHPAVLREQVTSPAGTTAAALRELEIHKVRAAFLAAMEAARDRSRALAEGS
>NC_008699.1|WP_011753973.1|510530_511481_+|proline-dehydrogenase-family-protein
MSLLRQPLLLLARSSLVKKVVSGMPVSAGIVRSYVPGETTESAVGATAELVDGGLRVTLDYLGEDTTDAEQADATVAAYLDVLQELSARGLTRNAEVSVKLSAIGQFLPDAVGFGGGEKIALENARTICRAARNAGTAVTLDMEDHTTTDSTLSILRELRKDFPETGAVLQAALHRTESDCRALAYEGSRVRLCKGAYLEPESVAFQDRLEISKSYVRCLKVLLAGEGYPMIATHDPRMIEIASSLASRYGRAAGTYEYQMLYGIRPEEQRRLVASGETMRVYVPYGTEWYGYLMRRLAERPQNLSFFVKSLVSKK
>NC_008699.1|WP_041546126.1|521043_522582_+|AMP-binding-protein
MRDIAELVSVAAAEHPDRLAVVEAGGRSLTWAGLEDEVGRIATGLGAAGILGGTRVLLAVGNRLEFVTTYLGVLRAQAVAVPVNPRSTVSELSRMVADSGARMVVGEPDTVEALREAVAGLDPAPLLVVIEAEPLPGERAHDELRALPARPVPPLQDPEKLAVLLYTSGTSGLPRAAMLTHRALLANLDQVAQVEPPMIHGDDVVLGVLPLFHVYGLNAVLGGILRHRAKLVLVERFDPHETLSLIDDEACSVVPVAPPVFAYWLGEEHLAEHLGPVRLVLSGSAPLAAELIDKFTARAGVPVHQGYGLTEAAPVVTSTLCSVTPQVGSVGAALPGVELRLVDESGRSPDGDDPGEIQIRGANLFSGYWPDGEGGPDDDGWWSTGDVGFLDPSGDLFLVDRIKDLVIVSGFNVYPVEVEEVLTEVDGVVEAAVIGVDDPVTGEAVVAYVRAPDADPAAIEEAVRVHCEQRLARFKRPSRIEVVDALPKTGTGKVQKGRLRGIERRRTLGLLE
>NC_008699.1|WP_011753984.1|522578_522824_+|glutaredoxin-family-protein
MSAPRVTLYTRPGCHLCDVAREVVERVCAELGEAYAEVHIDDDPELRERFTDEVPVTFVDGRQHDFWRVDEARLRAALATS
>NC_008699.1|WP_041546128.1|523025_523688_+|redox-sensing-transcriptional-repressor-Rex
MSARTSPESARDIPEATVARLPVYLRALVTLSEQGTATCSSEELAVAAGVNSAKLRKDLSYLGSYGTRGVGYDVDYLRYQIAREIGVTQDWPVVIVGIGNLGQALANYSGFRSRGFRVVALLDADPARHDQVVAGIEVRPFDHLERIVRDHAVAIGVIATPAVAAQDVADRMVAYGITSILNFAPTVLTVPAEVDVRKVDLSIELQILAYHEQRKGAVTA
>NC_008699.1|WP_011753986.1|523684_524977_+|glutamyl-tRNA-reductase
MSVLVVGISHKSAPVALLEQLALDGPGLHKLIDDVAASEHVTEATVIATCNRLEIYAEVDRFHGSVEEVSRLVVDRAGERTEAMLPHLYVHYDDGAVSHLFQVVAGLDSMAVGEGQILGQTRAALNAGQEIGTVGPALNVLFQQALRVGKRARAETGIDRAAPSLVSAALDRSRATVGELSGKRVLVVGAGSMAGLATSTVAARGTASVTVVNRTSGNADRLAEEYGARSATLAELAAELAVADVVISCTGATGTLITRDMVAAATVDGRELSILDLALPHDVDPTVADLPGVSLVGLTDLADELRDSDAGQEVEAVRQIVTQEVAAFLSARRQASVTPTVVALRSMATSVVEAEMERLTSRVPGLDDDIRAEVLHTVRRVADKLLHQPTVRVRELANETGAVSYAAALAELFALDQEAVDAVTRPEGLT
>NC_008699.1|WP_140403803.1|524985_525918_+|hydroxymethylbilane-synthase
MRVGTRASVLATTQSGLVADQLREALGREVELVTVSTEGDRTQAAGIPLQGGSATGVFVAALRDALLRGEVDVAVHSLKDLPTYPTEGITLAAVPVREDPRDVVVARDGLTLGELPVGSRVGTGSPRRVAQLHALGLGLEVVGIRGNVDTRIGKVRSGECDAVILARAGLARIGRLEAVTEVLDPLQMLPAPGQGALAVECRTDDPLAAQVAAALDDPRVRAAVTAERAVLATLEGGCSAPIGALAEIVEGEDGDELWVRSVALSPDGALSVRRSASGSPSDAAGVGTRLGEQMLADGADRLGDPAEVQQ
>NC_008699.1|WP_011753988.1|526009_527668_+|uroporphyrinogen-III-synthase
MTRGKTTTATGSGSTRGWVSFVGSGPGDPGLLTVRAVDLLRQADVVVTEVPDHAALVRTVLGLPLDAAGAEPAGPEIVDGGFGEDGQPLTHAARAKVVVRQAKRGLRVVRLMAGDPFLYASGPEEAQACVKAGLGFEIVPGVSSVSAVPAYAGIPLTTKDCREVAVVTCGERVDWSRYVDARTLVLLSAVGQIADISKALVAAGRSPETPVAMTRVGTTTEQATVTSTLERIGADARAARMTPPAITVVGDVVDLRETLSWFETKPLFGWRVLVPRTKEQAGSLSARLRGYGAVPDEVPTISVEPPRNPLQMDKAVRGLVEGRYEWIAFTSVNAVRAVREKFEEYGLDARAFSGLKIAAVGDKTAQAIAGWGLRADLVPSGEQSAAGLLADWPEYDELLDPINRVFLPRADIATENLVAGLVDLGWECDDVTAYRTVRAAPPPAPTRDAIKTGKFDAVVFTSSSTVRNLVGIAGKPHPSTIIAVIGPATAKTAEEHGLRVDVLAAKPDVDTLVDALADFGASRRIAMVEAGQPVTKPSDRKPSGRRKTTSAR
>NC_008699.1|WP_011753989.1|527692_528694_+|porphobilinogen-synthase
MSEVPVPPVVGPTVRPRRLRTTAALRRMVSETSLEARQLVLPVFVCEGLDEPRPISSMPGVVQHTRSSLLAAVTEAAELGLGGVMLFGIPERKDAVGSGAVDPAGILNLAITDVVGEVGDALTVMSDLCLDEFTDHGHCGVLTPDGKVDNDRTLSRYAEMALAQAHAGVDMVGPSGMMDGQVAVVRRALDAAGHTDVSILAYSAKYASAFFGPFREAVDSSLEGDRRTYQQDPANAREGVREAMLDVEEGADLVMVKPALAYLDVLHRVRDAVDVPVAAYNVSGEYAMLEAAAAKGWIDREPAILEALTSIRRAGADVVLTYWAAEVARILAR
>NC_008699.1|WP_011753990.1|528933_530103_-|lytic-murein-transglycosylase
MPTRSTRFGRGQKVMALVPLALLSAAWTASIAGVGASTATASAESESTALPDGSTVPTEAIKAPASVSTSGGLAPGVRGDGAGIVSTASTSGIPSAALAAYQRAETVINAADKSCHLSWQLIAAIGRVESDHGRTNGNTLDAQGVARPGIYGIALDGSHGTTRITDTDAGQYDADARFDRAIGPMQFIPSTWSVVGVDADGDGQRNPQDVDDAALATAVYLCSGSDDLSTPAGQRAAVYRYNHSSSYVDLVLSIAAAYLDGDFTSVPNGTTSAGYLVPAPAKPGQQGPKKHHGQPHATQTQGPGGGSQQPAPEPSPEPTAPAAPNPTGGGGGGDLPVPSVPPLPSTSIPPVDELLTVAQAIVQCTLDGYVDNILKDDDAFDQCVYDYTH
>NC_008699.1|WP_011753991.1|530332_531670_+|glutamate-1-semialdehyde-2,1-aminomutase
MTAGATLPTAASAALFERARAVTPGGVNSPVRAFNAVGGTPRFIRSARGAWLTDADGNEYVDLICSWGPMLLGHAHPEVQAAVSAAVARGTSYGAPTEPEVELAEEIAARAPVERVRFVSSGTEATMSAIRLARGFTGRDVVVKFAGCYHGHVDSLLASAGSGLATFAVPGTPGVPESSTALTLVLPYNDRAAVEKAFAEHGDRIACLITEAAPGNMGVVPPDADGSGGGFNGFLAETCARHGALFVSDEVMTGFRASRQGQWGLDGAVEGWRPDLMTFGKVMGGGFPAAAFGGRADVMSRLAPEGPVYQAGTLSGNPIATTAGLATLRLATDDVYAHIGAAADTIKTAASDALSRAGVEHVVQAAGTMFSVFLTAGPVRDFADASRTDVAAYAAFFHAMLDQGVYLPPSAYEAWFLSSAHDDRAVQTVLDALPTAARAAAAAQT
>NC_008699.1|WP_011753992.1|531682_532363_+|histidine-phosphatase-family-protein
MNQTPDTIVHLLRHGEVHNPEGVLYGRRDGFHLSDLGVQMAEKVAEAIKDRDIVHLRSSPLERAQETGAPLARARGLDIVTDERVIESTNKFEGRRFAGGANALRDPRTWALLWNPFRPSWGEPYKQVVARMMAAVDDAREVARGHEAVVVSHQLPIWITRLAAEKRSFLHDPRRRQCTLCSLTSFHFVGDRLTQVSYSEPAGDLIPVQDKSAPFSAGGAPEQRRP

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Crispr_ID: NC_008699_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_12

546946-547031

Orphan

Consensus_repeat	Method
TTCCCCGGTGAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_12

>merge|NC_008699|12|546946-547031|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCGGAACTGTTGACCCGAAACTTCGGGCCAGAAGTTCCAACTTCCCCGGTGAACCGGGGAAACCG

>NC_008699|12|12|546946-547031|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCG	GAACTGTTGACCCGAAACTTCGGGCCAGAAGTTCCAAC
TTCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011754013.1\|551531_552086_+\|NADH-quinone-oxidoreductase-subunit-B	unknown	unknown	gnl\|CDD\|235797
NC_008699.1\|WP_011754002.1\|540288_541902_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	unknown	unknown	gnl\|CDD\|236020
NC_008699.1\|WP_041546136.1\|554971_556282_+\|NADH-quinone-oxidoreductase-subunit-NuoF	unknown	unknown	gnl\|CDD\|131014
NC_008699.1\|WP_041546133.1\|547043_548312_-\|isochorismate-synthase	unknown	unknown	gnl\|CDD\|224091
NC_008699.1\|WP_011754014.1\|552082_552835_+\|NADH-quinone-oxidoreductase-subunit-C	unknown	unknown	gnl\|CDD\|181115
NC_008699.1\|WP_140403789.1\|538328_539339_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236108
NC_008699.1\|WP_041546134.1\|548377_549013_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011753998.1\|536910_537180_+\|DUF4229-domain-containing-protein	unknown	unknown	gnl\|CDD\|379415
NC_008699.1\|WP_011754010.1\|549034_549964_-\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|341130
NC_008699.1\|WP_011754007.1\|546288_546924_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|316044
NC_008699.1\|WP_011754004.1\|543867_545064_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NC_008699.1\|WP_083768053.1\|545624_546290_-\|LysE-family-transporter	unknown	unknown	gnl\|CDD\|224198
NC_008699.1\|WP_041547077.1\|541944_543810_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223104
NC_008699.1\|WP_041546131.1\|539335_540292_+\|o-succinylbenzoate-synthase	unknown	unknown	gnl\|CDD\|235084
NC_008699.1\|WP_086000423.1\|545121_545559_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NC_008699.1\|WP_041546130.1\|537408_538284_-\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	unknown	unknown	gnl\|CDD\|235695
NC_008699.1\|WP_011754016.1\|554171_554963_+\|NADH-quinone-oxidoreductase-subunit-NuoE	unknown	unknown	gnl\|CDD\|181024
NC_008699.1\|WP_011754011.1\|550119_550809_+\|demethylmenaquinone-methyltransferase	unknown	unknown	gnl\|CDD\|234689
NC_008699.1\|WP_011754015.1\|552834_554175_+\|NADH-quinone-oxidoreductase-subunit-D	unknown	unknown	gnl\|CDD\|180385
NC_008699.1\|WP_011754012.1\|551158_551518_+\|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl\|CDD\|181171

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011754013.1\|551531_552086_+\|NADH-quinone-oxidoreductase-subunit-B	gnl\|CDD\|235797	PRK06411, PRK06411, NADH-quinone oxidoreductase subunit NuoB.	9.30202e-100
NC_008699.1\|WP_011754002.1\|540288_541902_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	gnl\|CDD\|236020	PRK07449, PRK07449, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Validated.	4.55201e-146
NC_008699.1\|WP_041546136.1\|554971_556282_+\|NADH-quinone-oxidoreductase-subunit-NuoF	gnl\|CDD\|131014	TIGR01959, NADH-quinone_oxidoreductase_subunit_F, NADH-quinone oxidoreductase, F subunit. This model describes the F chain of complexes that resemble NADH-quinone oxidoreductases. The electron acceptor is a quinone, ubiquinone, in mitochondria and most bacteria, including Escherichia coli, where the recommended gene symbol is nuoF. This family does not have any members in chloroplast or cyanobacteria, where the quinone may be plastoquinone and NADH may be replaced by NADPH, nor in Methanosarcina, where NADH is replaced by F420H2. [Energy metabolism, Electron transport].	0
NC_008699.1\|WP_041546133.1\|547043_548312_-\|isochorismate-synthase	gnl\|CDD\|224091	COG1169, MenF, Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	7.11958e-93
NC_008699.1\|WP_011754014.1\|552082_552835_+\|NADH-quinone-oxidoreductase-subunit-C	gnl\|CDD\|181115	PRK07785, PRK07785, NADH dehydrogenase subunit C; Provisional.	1.45767e-151
NC_008699.1\|WP_140403789.1\|538328_539339_+\|AMP-binding-protein	gnl\|CDD\|236108	PRK07824, PRK07824, o-succinylbenzoate--CoA ligase.	4.91528e-83
NC_008699.1\|WP_011754012.1\|551158_551518_+\|NADH-quinone-oxidoreductase-subunit-A	gnl\|CDD\|181171	PRK07928, PRK07928, NADH dehydrogenase subunit A; Validated.	1.37668e-66
NC_008699.1\|WP_011753998.1\|536910_537180_+\|DUF4229-domain-containing-protein	gnl\|CDD\|379415	pfam14012, DUF4229, Protein of unknown function (DUF4229). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 122 amino acids in length.	2.84373e-13
NC_008699.1\|WP_011754010.1\|549034_549964_-\|peptidoglycan-binding-protein	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	2.20395e-21
NC_008699.1\|WP_011754007.1\|546288_546924_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|316044	pfam13483, Lactamase_B_3, Beta-lactamase superfamily domain. This family is part of the beta-lactamase superfamily and is related to pfam00753.	1.01941e-26
NC_008699.1\|WP_011754004.1\|543867_545064_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.01626e-75
NC_008699.1\|WP_083768053.1\|545624_546290_-\|LysE-family-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	6.53295e-08
NC_008699.1\|WP_041547077.1\|541944_543810_+\|cation:proton-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	2.93032e-79
NC_008699.1\|WP_041546131.1\|539335_540292_+\|o-succinylbenzoate-synthase	gnl\|CDD\|235084	PRK02901, PRK02901, O-succinylbenzoate synthase; Provisional.	2.35371e-151
NC_008699.1\|WP_086000423.1\|545121_545559_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	4.13439e-12
NC_008699.1\|WP_041546130.1\|537408_538284_-\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	gnl\|CDD\|235695	PRK06080, PRK06080, 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated.	2.04221e-112
NC_008699.1\|WP_011754016.1\|554171_554963_+\|NADH-quinone-oxidoreductase-subunit-NuoE	gnl\|CDD\|181024	PRK07539, PRK07539, NADH-quinone oxidoreductase subunit NuoE.	2.74661e-87
NC_008699.1\|WP_011754011.1\|550119_550809_+\|demethylmenaquinone-methyltransferase	gnl\|CDD\|234689	PRK00216, ubiE, bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE.	1.27019e-122
NC_008699.1\|WP_011754015.1\|552834_554175_+\|NADH-quinone-oxidoreductase-subunit-D	gnl\|CDD\|180385	PRK06075, PRK06075, NADH-quinone oxidoreductase subunit D.	0

>NC_008699.1|WP_011754007.1|546288_546924_+|MBL-fold-metallo-hydrolase
MRITKFGHACVRVEHAGTTVVLDPGVFTDPAALDGADAVLITHEHADHYLPDHLLATDAPVFTIEAVAAHVREDVPAVAERLTVVAPGETFDVGVPVRAVGELHAVIHPEFPRFFNSGYVLTLGDRKVYHPGDALTEPGEDVDVLLVPVSGPWLKASEAIDFARAVRAPRNLAIHDRVYSEAGLGIIDGHMDKFLPKEGLEYVRRPDGHDL
>NC_008699.1|WP_083768053.1|545624_546290_-|LysE-family-transporter
MRPTVIRWPSPSGSRDDPRVLEVVLSGLVTGWAIAIPIGAVGAFLVTLSARTSFRVGGAGALGVATVDGGYAALAVVAGSAIAAALEPVSRALSIASGLVLLGVAGLTAAHALRSAGRVREVPSLRPRTAYAMFLGITAVNPTTVVYFAAVVLGNQGLVAGPAEGVVFVLAAFLASASWQLLLAGGGAALGRIATGHRAHLVTGLVSAVVVAGLAVHTMLA
>NC_008699.1|WP_086000423.1|545121_545559_-|GNAT-family-N-acetyltransferase
MHAACWREAYAPYVDAALLEQRVTDLDRWVAAWTKHLVDGPPRVLAEAGGEPVGFAVVGPSRDDDGATPQELYAIYVRAAWWGTGLGQALWDAVRPDAACSLWVLEDNARAQAFYRRNGFVPDGAREHYAGLDTCEIRMVRPTNP
>NC_008699.1|WP_011754004.1|543867_545064_-|cytochrome-P450
MTYFDLSDPAFDVTSAQVHAARDQDWYVETNWGWAVLRYAEVSALLRDRRFRQGNARWPAQNGIHSGLFSDWWQETLLSLEGDDHARIRRLLMPAFRNKTIAAMRPRFQALANELIDGFADRGSVEFVSEFAEPYAARIICVLLGLPEDHWQQVAHWADDLGASFSIDVGNQVPRIEAALDGLYGYVDEVVADRAAHPREDLVTTLVQATADGDRLSRHELGVALVFLAFAGMETTRNQLGLAVQTLLEHPDQWRLLGEHPELGENAVEEVMRVNPTVTWVTREALEDVELQGLRIPKGGIVQMLSHSAGTDPAAMPDPSFDITQQRPPHHGFGAGVHHCLGHFVARTDMAVALPLLARRMPGAEPDGPGRWLPISGNTGALSFPIRFEHPAPIGSCA
>NC_008699.1|WP_041547077.1|541944_543810_+|cation:proton-antiporter
MDTALFLVALAVAVLAGVVVAGRIGVPAPLLLVVAGVAASFLPFLPEVHLEPDVVLFGLLPPLLYSAAITSSLVDFNANRRPILLLSVGLVVFTTLGVGVLVHELVPGLSWPVAFALGAVVAPPDAVAATSIGRHIGLPRRVVTILEGESLFNDATALVSLQTALGATLVGVELWRVGLDFVVAAGGGVLIGVVVFLVVGAMRRRLSDPMLDVAMSFVIPFTAFLAAEEVHASGVVAVVTAGLLLGHRAPVLQTAQSRIAERINWRTIAFLLENTVFALIGLQARWLFDDLGESTLSPARIIAVSAATLVAVIVLRLVWVFLSRSLLVRPRVDPATGQVPPWSFTLLLGWSGMRGVVTLAAAFLIPPDTRHREVLLVVAFAVVAGTLLVQGLSLPWLTRRLHVPAPDPLDDALARATLLQQASKAAVEELERQEYDDQAGVGDLIRQRLDQRNFAAWERLGTTADQESPAAVYYRIRMAMIAAERRRILEIRRSGTVASEVIAEVLSMLDVEESMLDNAHQERDEAEDYARRRWTLGETCDDLGRYPVVDAEPATYCQACLDEGTRWVALRRCLECGNLACCDSSPRQHATAHFRETQHPVMQSAEPGEDWRWCYLHHLTA
>NC_008699.1|WP_011754002.1|540288_541902_+|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase
MTAPEPAPESATATARRILAALVEAGVTEIVVAPGSRNAPLSFAAYDAAAAGLVRLHTRLDERTAGFLALGLTRSGRRAAVVCTSGTAVANLHPAVLEAAHAGVDLVVVSADRPARLRGTGANQTTDQVGIFGPLVPTQDASGPVELLTAGPVHLNVPLEEPLVPDDRWLPDVVPGEPAHRVIPASLTVLARGPRTVVVAGDDAGPRVRVLAEQAGWPLLAEPSSGSRTGDNAIRTYRLLLDGDLGARVERVVVGGHPTLSRPVSRLLARPDVEVVDLGAWGVWSERPFPVHSRILGGVGVDAPVDAADGTADDTDWLEEWRTADRAVSARLDALLAAEPGLTPHEVAGAVARALPAGGLLVVGASSPIRDLDLMVPRYDVGARRKVVANRGLAGIDGTISTAVGAALGRPRSTRALTLMGDVTFLHDAGALVIGPGEAVPDLTIVVVNDDGGSIFAMLEQGAAEYADQYDRLFGTPHRVDLASLCAATRTPHWRVDSLAELEHALASPAGGIEVVEAVVRRDNRRDLDERIRALRP
>NC_008699.1|WP_041546131.1|539335_540292_+|o-succinylbenzoate-synthase
MIVWSVPMRTRFRGITVREGVLLRGPADAERPGWGEWSPFLEYDAAVAEPWLRCAEEAAAGDWPAPLRDRVPVNVTVPAVGPQQAHAIVLAGGCRTAKVKVAEPGQTAADDQARLEAVRDALGADGRVRIDVNGLWDLDTAVASIPVLDRAAGGLEYVEQPCASVEDLAAVRRRVDVPIAADESIRRAADPYRVRDLEAADVAVLKVQPLGGVRACLRIAEDIGLPVVVSSALETSVGIAAGVALAAALPELPYACGLATVQLLTADVVTESLLPVGGELPVRAVQVDESLAPADPDRVAHWEARLAEVRALRQDRPS
>NC_008699.1|WP_140403789.1|538328_539339_+|AMP-binding-protein
MDRVDTVVEPVAGWLAADDPEPWVVETSGSTGAPKRVVLPRDAVLASVRASARRVGATGQWLLALPPAYVAGLQVVCRSLAAGHPPVLLEDHGSFAAAAAAMAPGERFVSLVPTQLHRLLETDAPALATFHTVLLGGGPIDPALRRRAADAGVHVIATYGSAETAGGCVYDGVALDGVAVALDADGRVRIAGPTLFAGYAGDPELTARVLVDGWFRTADAGRLDEDGRLQVLGRIDDMVVTGGVNVPAPAVAARLREHPDVEAAEVLGVPDEEWGNRVVAFVVGPVSLDVARDWVAAAHPRSWAPRQLVALDTIPLLGNGKPDRLALRHAAVEEWA
>NC_008699.1|WP_041546130.1|537408_538284_-|1,4-dihydroxy-2-naphthoate-polyprenyltransferase
MATPDQWLAGARPRTLPAAVSPVLAGTGVAAYADGLVWWKALLALVVALALQVAVNYANDYSDGIRGTDADRVGPMRLVGSGAARPAAVKRAAFLAFGVAAGAGLVLAATTAWWLVAVGLVSVLAAWFYTGGSKPYGYLGLGEVMVFVFFGLVAVLGTAYVQTEAWEWAALYAAVGVGTLACAILVANNLRDIPTDAVAGKRTLAVVLGDRRTRSLFLLLVVLAAAAVVAVAATTTWWALAGLGFLVLAGPAARTVLGGAAGPGLIPVLQQTGLAELLWAVLVAAALVAGG
>NC_008699.1|WP_011753998.1|536910_537180_+|DUF4229-domain-containing-protein
MKEFWIYTALRFLLFVGSLGIVAGVWFLLADSVPILWAVVIAFVISGAGSYFLLNRPREALARRVQTRAERMTAKIEEMRAKEDVDDEA
>NC_008699.1|WP_041546133.1|547043_548312_-|isochorismate-synthase
MTSSPTPGDPPPAPADALVVRTVRLDLDQAASLLDLVPADRPVTWLRRGDGLVGWGVAAQVRTSGATRFADAVKWWSETIARADVHDDVNEPGTGLVSFGSFAFADDPGDSILVLPRVVVGRRGDVTWLTTVGEVGPPLGPVERPAAPAAVSFADGALNGEQWMSVVADAVARINAGDLEKVVLARDLVATASDPVDVRWPLGRLGETYPMCWTFHVDGMFGATPEMLVRRERGLVTSRVLAGTIRRTGDHERDLALAATLAHSSKDLEEHEYAVRSVADALEPHCSSMNVPEAPFVLHLPNVMHLATDVAGVVHDAATVSSLQLAEALHPSAAVGGTPTPVATALIADIEGMDRDRYAGPVGWMDASGDGEWGIALRSARLEGRTVRLFAGCGIVADSDPAAELAEAQAKFVPVRDALTAS
>NC_008699.1|WP_041546134.1|548377_549013_+|hypothetical-protein
MTSRTSAPTSGRPSTWAGIAIGVIALGLLALFAIALPKAVGEDDGAARLVLPDTLPGGYAAADDPASFEGGDYADQADSIAEQEKSNSAYGNRVLPEVLGHAAATRTYVLDGTKAVFVQVFDAEGGAFAPNSIPDPEASGGAPANEVTNVGDGVCILSYGQGSTDAGPADPVFSQCQVTRDGRTVQIGAPDVDAEDLVATADGLLDDLQGS
>NC_008699.1|WP_011754010.1|549034_549964_-|peptidoglycan-binding-protein
MLLARRLLLLVAVAALLCAAAFVAGDALDGGSSARPAASGAGAASTDQPATTDPTAAPSSSDPTATPGSSPTDAPAPTAADEPTRQPTHLPTRQPTLVPGPRLLGPGDQGDEVRDLQARLKQIYWFNTDVTGVYGDVTATAVRGFQAKREIPVTGEVDQRTLDRLRAMTSTPTGAELHNRGNTPGALDARCRTGRVLCIDKTSSTLRWVVDGTVRQTLDVRFGASTTPTREGVFHVYLKDADHVSRLYGSAMPYSMFFSGGQAVHYSSDFAAVGYAGASHGCVNVRDYDALGLLYGQVRVGDTVVVYWS
>NC_008699.1|WP_011754011.1|550119_550809_+|demethylmenaquinone-methyltransferase
MVRAELDKQPSDVRRMFDAVARRYDVTNDVLSMGQDRRWRRAVIAAVDPQPGERVLDLAAGTGTSSQPFADRGASVVPCDFSLGMLRVGKSALPHLPFTAGDGTRLPFADATFDAVTISFGLRNIVDPLSGLRELHRVTRPGGRLVVCEFSHPTFAPFRTVYLEYLMRALPSIARAVSSAPDAYVYLAESIRAWPDQEGLAAMVAEAGWRAPAWRNLSGGIVALHRATR
>NC_008699.1|WP_011754012.1|551158_551518_+|NADH-quinone-oxidoreductase-subunit-A
MELYTPVVVLVVLATVFALGGAVMAFAVGPTRYNRVKLDSYECGIEPTPQAVGGGRFPIKYYITAMLFIVFDIEIVFLYPWAVQFDELKFFGLVEMVLFIATVFVAYAYVWRRGGLDWD
>NC_008699.1|WP_011754013.1|551531_552086_+|NADH-quinone-oxidoreductase-subunit-B
MGIEEKLPSGVLLSTVEGLAGYMRKASFWPASFGLACCAIEMMTSGGPKHDLGRFGMEVFRASPRQADVMIVAGRVSQKMAPVLRQIYDQMPEPKWVLAMGVCASSGGMFNNYAVVQGVDHVVPVDMYLPGCPPRPQMLIDAILKLHDKVQHTKMGAHRAAEIEELETAALRALPTSEMKGQLR
>NC_008699.1|WP_011754014.1|552082_552835_+|NADH-quinone-oxidoreductase-subunit-C
MSDDSSDVKPGPKGPEQPAVEQSPENVPAPTGEVHQVGARHGMFGVRGTGDTSGYGGLNQAIVLPGDAQRPYGGWFDEVADGLAAATREAGLEIAAPRVVIHRGEITFHLRREDLLPVAQVLRDDERLRFEFCAGVSGVHYPDETGRELHAVYHLLSMTHNRRIRLEVAVPDADPHIPSIVPVYPTNDWHERETYDMFGIIFDGHPALTRILMPDDWPGHPQRKDYPLGGVPVEYKGGTVPPPDQRRSYN
>NC_008699.1|WP_011754015.1|552834_554175_+|NADH-quinone-oxidoreductase-subunit-D
MADQDLYSGSSETTEGRVFTVTGQDWDSIAEGLAEDEAQERIVVNMGPQHPSTHGVLRLILELEGETVTEARAGIGYLHTGIEKNMEYRTWTQGVTFCTRMDYLSPFFNEMTYVLGIERLLDIEDRVPEKAQVMRVLLMELNRISSHLVAIATGGMELGALTVMTIGFRERELVLDLFELITGLRMNHAFIRPGGVAQDMPPGALDEIRGFVALMKKRLPEYADLCNANPIFKGRLEGIGHLDLAGCLALGLTGPVLRSTGYPWDLRKTQPYCGYETYDFDVQTWDTSDSYGRFRIRLNEMWESLRIIEQAADRLAGLDGAPVMIEDKKIGWPSQLAIGSDGMGNSLDHIRHIMGESMEALIHHFKLVTEGFRVPPGQAYVPVESPRGELGAHVVSDGGTRPFRAHFRDPSFTNLQATSVMAEGGMVADVIVAIASIDPVMGGVDR
>NC_008699.1|WP_011754016.1|554171_554963_+|NADH-quinone-oxidoreductase-subunit-NuoE
MSLTQETYGELQEIAARYPEPRSGLLPMLHLVQSAEGRITPEGIEACADLLGVTAAEVSGVATFYTMYKRRPVGDYHVGVCTNTLCAVMGGDAIFDRLKSDLGVGNDETTEDGKITLEHIECNAACDYAPVMMVNWEFMDNMTPDTAARIIDDLRAGNEVHSTRGPRIVTWREAERVLAGFPDDLADEGPAAGRASLVGLGLARERGWAAPSSEQGPAAHDVPEEPAQVEQAAADASPPPSEAATVEKESGTSETAAEKGDAQ
>NC_008699.1|WP_041546136.1|554971_556282_+|NADH-quinone-oxidoreductase-subunit-NuoF
MTDVLTPVLTDNWDQERSWTLAAYESRGGYRAVDTAFAMEPDAVIDAVKESGLRGRGGAGFPTGMKWGFIPQDNPRPKYLVVNADESEPGTCKDIPLMMASPHTLVEGVIISSYAIRANKAFIYIRGEVLHVIRRVQRAVQEAYAAGHLGTNIHGSGFDLDVVVHAGAGAYICGEETALLEGLEGRRGQPRLRPPFPAVAGLYASPTVINNVESISSVPSIIGRGHAWFASMGTEKSKGVGIFSLSGHVKRPGQYEAPLGITLRTLIDLAGGIREGHELKFWTPGGSSTPLLTAEHLDVPLDFEGVGSAGSMLGTRALQIFDDSVCVVRAVLRWSEFYKHESCGKCTPCREGTWWLVQVLTALEKGDGTEEDLDLLLDQCDNILGRSFCALADGATSPIVSSIQFFRDEYVAHLTHGGCPFDPAAATLFATAGAQA

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Crispr_ID: NC_008699_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_13

705624-705708

Orphan

Consensus_repeat	Method
TCCCCGGTGAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_13

>merge|NC_008699|13|705624-705708|CRISPRCasFinder
TCCCCGGTGAACCGGGGAAACCGGAACTCCGGGGCCGAAACTTCGGGCCAACAGTTCCAACATCCCCGGTGAACCGGGGAAACCG

>NC_008699|13|13|705624-705708|CRISPRCasFinder
TCCCCGGTGAACCGGGGAAACCG	GAACTCCGGGGCCGAAACTTCGGGCCAACAGTTCCAACA
TCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011754130.1\|694653_695829_-\|fumarylacetoacetase	unknown	unknown	gnl\|CDD\|215461
NC_008699.1\|WP_011754140.1\|705813_706992_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NC_008699.1\|WP_011754147.1\|711521_712544_+\|UDP-N-acetylmuramate-dehydrogenase	unknown	unknown	gnl\|CDD\|237552
NC_008699.1\|WP_011754143.1\|709508_709679_+\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NC_008699.1\|WP_011754146.1\|711145_711529_+\|MaoC-family-dehydratase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|239537
NC_008699.1\|WP_011754145.1\|710747_711149_+\|MaoC-family-dehydratase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379194
NC_008699.1\|WP_049774531.1\|708399_709137_-\|thioesterase-family-protein	unknown	unknown	gnl\|CDD\|379298
NC_008699.1\|WP_011754149.1\|712983_714015_-\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480
NC_008699.1\|WP_011754141.1\|707009_708410_+\|amidase	unknown	unknown	gnl\|CDD\|181154
NC_008699.1\|WP_041546194.1\|700110_700413_+\|DUF1905-domain-containing-protein	unknown	unknown	gnl\|CDD\|378097
NC_008699.1\|WP_011754136.1\|700423_701272_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227760
NC_008699.1\|WP_011754138.1\|703881_704937_+\|pirin-family-protein	unknown	unknown	gnl\|CDD\|224655
NC_008699.1\|WP_011754144.1\|709746_710715_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011754129.1\|693163_694732_+\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	unknown	unknown	gnl\|CDD\|274589
NC_008699.1\|WP_049774530.1\|695825_696716_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_140403824.1\|698913_699978_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340842
NC_008699.1\|WP_011754133.1\|698008_698875_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381326
NC_008699.1\|WP_011754148.1\|712564_712987_-\|DUF4190-domain-containing-protein	unknown	unknown	gnl\|CDD\|379388
NC_008699.1\|WP_011754137.1\|701440_703822_+\|FdhF/YdeP-family-oxidoreductase	unknown	unknown	gnl\|CDD\|273765
NC_008699.1\|WP_011754132.1\|696777_697992_+\|homogentisate-1,2-dioxygenase	unknown	unknown	gnl\|CDD\|226039

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011754130.1\|694653_695829_-\|fumarylacetoacetase	gnl\|CDD\|215461	PLN02856, PLN02856, fumarylacetoacetase.	3.84362e-147
NC_008699.1\|WP_011754140.1\|705813_706992_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	2.5553e-50
NC_008699.1\|WP_011754147.1\|711521_712544_+\|UDP-N-acetylmuramate-dehydrogenase	gnl\|CDD\|237552	PRK13903, murB, UDP-N-acetylmuramate dehydrogenase.	0
NC_008699.1\|WP_011754143.1\|709508_709679_+\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	3.05611e-22
NC_008699.1\|WP_011754149.1\|712983_714015_-\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	4.16378e-137
NC_008699.1\|WP_011754145.1\|710747_711149_+\|MaoC-family-dehydratase-N-terminal-domain-containing-protein	gnl\|CDD\|379194	pfam13452, MaoC_dehydrat_N, N-terminal half of MaoC dehydratase. It is clear from the structures of bacterial members of MaoC dehydratase, pfam01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerize to form a whole. Divergence of the N- and C- monomers in higher eukaryotes has led to two distinct domains, this one and MaoC_dehydratas. However, in order to function as an enzyme both are required together.	1.29675e-20
NC_008699.1\|WP_049774531.1\|708399_709137_-\|thioesterase-family-protein	gnl\|CDD\|379298	pfam13622, 4HBT_3, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	1.55433e-37
NC_008699.1\|WP_011754141.1\|707009_708410_+\|amidase	gnl\|CDD\|181154	PRK07869, PRK07869, amidase; Provisional.	0
NC_008699.1\|WP_041546194.1\|700110_700413_+\|DUF1905-domain-containing-protein	gnl\|CDD\|378097	pfam08922, DUF1905, Domain of unknown function (DUF1905). This domain is found in a set of hypothetical bacterial proteins.	5.08175e-27
NC_008699.1\|WP_011754136.1\|700423_701272_-\|hypothetical-protein	gnl\|CDD\|227760	COG5473, COG5473, Predicted integral membrane protein [Function unknown].	4.85024e-09
NC_008699.1\|WP_011754138.1\|703881_704937_+\|pirin-family-protein	gnl\|CDD\|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	3.2164e-70
NC_008699.1\|WP_011754146.1\|711145_711529_+\|MaoC-family-dehydratase-N-terminal-domain-containing-protein	gnl\|CDD\|239537	cd03453, SAV4209_like, SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.	4.85574e-39
NC_008699.1\|WP_011754129.1\|693163_694732_+\|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB	gnl\|CDD\|274589	TIGR03459, crt_membr, carotene biosynthesis associated membrane protein. This model represents a family of hydrophobic and presumed membrane proteins found in the Actinobacteria. The genes encoding these proteins are syntenically associated with (found proximal to) genes of carotene biosynthesis ususally including phytoene synthase (crtB), phytoene dehydrogenase (crtI) and geranylgeranyl pyrophosphate synthase (ispA).	2.35335e-50
NC_008699.1\|WP_011754133.1\|698008_698875_+\|aldo/keto-reductase	gnl\|CDD\|381326	cd19100, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	3.52306e-77
NC_008699.1\|WP_140403824.1\|698913_699978_-\|glycosyltransferase	gnl\|CDD\|340842	cd03814, GT4-like, glycosyltransferase family 4 proteins. This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.	6.21333e-42
NC_008699.1\|WP_011754148.1\|712564_712987_-\|DUF4190-domain-containing-protein	gnl\|CDD\|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	3.52077e-06
NC_008699.1\|WP_011754137.1\|701440_703822_+\|FdhF/YdeP-family-oxidoreductase	gnl\|CDD\|273765	TIGR01701, Hypothetical_protein_Rv2900c/MT2968/Mb2924c., oxidoreductase alpha (molybdopterin) subunit. This model represents a well-defined clade of oxidoreductase alpha subunits most closely related to a group of formate dehydrogenases including the E. coli FdhH protein (TIGR01591). These alpha subunits contain a molybdopterin cofactor and generally associate with two other subunits which contain iron-sulfur clusters and cytochromes. The particular subunits with which this enzyme interacts and the substrate which is reduced is unknown at this time. In Ralstonia, the gene is associated with the cbb operon, but is not essential for CO2 fixation.	0
NC_008699.1\|WP_011754132.1\|696777_697992_+\|homogentisate-1,2-dioxygenase	gnl\|CDD\|226039	COG3508, HmgA, Homogentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	9.94625e-58

>NC_008699.1|WP_011754138.1|703881_704937_+|pirin-family-protein
MSNLEDRPDEVDGACAVTSGIEIMTPRDVPLGGPRAMRVRRTLPQRQRSLIGAWCFVDHYGPDRVADTGGMSVAPHPHTGLQTVSWLFTGEVEHRDSAGNHAMVRPGEVNLMTAGRGISHSEVSPAATETLHGAQLWVALPDADRFTDPGFAHHAPPAVTGDGWTARVFLGSLLGDSSPVPTYTPLLGAELLLGPGTTLTLDVDETFEHGVLADTGVLSVAGVETKQNDLAYVPPGRSTLTLTAYDEPVRLLLLGGPPFPESIVMWWNFVGRSHDEIVAFREEWQAQVLDPDGAERAPAEAGGRREDGGAYARVVRDSQLVREGRFGVVVGDHLPPIPAPPLPNVRLRPRT
>NC_008699.1|WP_011754137.1|701440_703822_+|FdhF/YdeP-family-oxidoreductase
MGRRPPHRDIDERELDVDPPKRTAAGVPAVAVAMKRAVEQMGVRRTAQTLLKLNQADGFDCQGCAWPDPDPSHRATAEFCENGAKAVTEEATRRHLHRGFFAAHPLTELRERSDYWLGQQGRITEPMVLREGGTHYEPIGWDEAFATIARHLQALESPDQAIFYTSGKTSNEAAFAYQLFVRAFGTNNLPDCSNMCHESTSVALAEVIGIGKASVTIRDVLEADLIVIAGQNPGTNHPRMLTALEGAKRNGARIIAVNPLKEAGLVRFKNPQRPRGIVGHGTELADLHLPLRINGDLALFQAIGALLLEWGCVDHEFVDRHTWGFEAWAEHLRTLDWDVVRRSTGLTREQIEEAARMFRDSRATVICWAMGITQHRNAVATVKEFANVAFLQGNIGRPGAGLFPVRGHSNVQGDRTMGIWERPPGHFLDKLRDEFGFEPPREHGFDSVAAIKALRDGDAKVFFGLGGNFVSAAPDTEVTEEAFRRAALTVHVSTKLNRSHVVHGREALILPALGRSEKDLTGGRVQRVTVEDSTCSVHASQGPLEPASPYLRSEVDIVCSLAQAVLGDRYGLPWQEFRADYTEIRRRIARVVPGCAAYDEKVDRPGGFVLPHPPRDSRTFPTEKDRAIFTVSPTTVLEVPEGRLLLQTLRSHDQFNTTIYGLDDRYRGISGGRRVVFVHADDIAALGLEEGEHVDLVSEWEDGSQRRAPSFRVVAYDTPRGCAAAYYPETNPLVPLDSTAEGSNCPTSKSVVVRLDRADGGPQGVTAGSDVGTITPAGRGDEGKRHVEPEHLS
>NC_008699.1|WP_011754136.1|700423_701272_-|hypothetical-protein
MSTNEPPPPDQAPPPPLPPPSGDGYGGPPPPTGGYGENPPPPPPAPSYGGGDGSGYSLGNALSYGWAKFQANTAQIILSAVVLVVALVVVAVLGTFVMNALTTDASCSVQNGSLTCDDGTGFFGRLILQSLLSAVLLVVAWIIGAGLVRASLNVTAGRPFLFADVIKTDNLGSVVVASVIIAVATFVGTILCYLPGLVVGFATSYTLFFIIDKNMAPVDAIKASVLFVKDNLAATIVWYIVGGLVAAVGFVICVVGALVSVPVVLLGTAYTYKTLNREPVAP
>NC_008699.1|WP_041546194.1|700110_700413_+|DUF1905-domain-containing-protein
MAGWTCEFDAELWEWESSPQGTAWVFLTVPAEETEEIRLRSGPPRGFGSVRVEVTLGGSTWRTSVFPDQERGYVLPVKKAVRRAESLEVGDPARLRLELV
>NC_008699.1|WP_140403824.1|698913_699978_-|glycosyltransferase
MKTAVAALGAGYVTAGVDRLLVVPGPVDAATTTEHGDVVQVRAPRVGGGYRLIVEPWRVVDVLERFAPTSVELSDKLTLLPVTRWARRRGVGSVLFSHERLDDMFAMRSGLETTSKVSIGLLNRLLVRSFDTLVVTSDYAQREFQALADAAGCPTVRVPLGVDLETFRPHPAAASDVLRLAHVGRLSREKSPHLAVATAVELHRRGVPVRMDVYGDGPHLDELVELAAGAPVTFHGFIAGRADLSHRIAAADVALSVCPGETFGLAVLEALASGTPVVTASRGGARELVDEQSGGWAESDPAALADAVLEVAARPVAVRRQAARRRAELFPWQATVDRMLAVHAAVTDGARVPA
>NC_008699.1|WP_011754133.1|698008_698875_+|aldo/keto-reductase
METRRLGRLEHRSTVLIYGAAALSEVTQDVADRSIQEALDGGINHFDVAADYGDAELRLGPWLPRIRDRIFLATKTGRRDRESAWQEINRSLERLQTDHVDLLQLHAVGDLADLDLATGPGGALEAALRAQEEGLVGAVGITGHGAQAPATHLEALRRHPFATVLTPLNPVLWRDESYRADYQALVAEVRRQDAGLMTIKTASRRNWPEGDEHRYSTWYEPYDDQARITAAVSWVLAHDEVTGLATAGDVRLLGMFLEAERTRVAAAQAEHLLAGDPRYSSPFVAMPF
>NC_008699.1|WP_011754132.1|696777_697992_+|homogentisate-1,2-dioxygenase
MAHYRRIGAVPPKRHTQARDPDGRLYYEELMGEEGFSSDSSLLYHRGVPSAIVAAEPWELPDQSRTPNHPLKPRHLRLHDLETGGDAVTSRRLVLANADVRISYVVAGSEPSAYYRNAIGDECVYVESGAGVVETVFGVVGYRAGDYVVIPRATTHRWVPAPGSEDPSRLYAIEANSHIAPPKRYLSRYGQLLEHAPYCERDLYGPTQPFTADGGDVDVLVKHRTGGGIVGTRMTYATHPFDVVGWDGCLYPYTLNIEDYMPITGKVHQPPPVHQVFEGHNFVVCNFLPRKVDYHPLAIPVPYYHSNVDSDEVMFYVGGDYEARKGSGIRIGSISLHPGGHAHGPQPSAIEASLGVEYFEESAVMVDTFAPLDLGEAGLAVEDPAYAWSWAGRGPEDPPVFSNS
>NC_008699.1|WP_049774530.1|695825_696716_-|hypothetical-protein
MVRVATVSTQPPAPALGGAWRGLVDDAAIFPPGDAPLAEATARHLARRAQPGADLVGTFVVRDTDLPALKATPLALSVVVTGGAGQVAGTVALARKLHVAVEGVELALRDPDDLLGAARRVGAAVDAARAEGQLDDHVPVFVEIPHVGSTASWLAAADEVAAQEFRLKFRTGGLDATAFPHAHALARWIDAALDRETPFKCTAGLHHAVRHTGPAESGGFEHHGFLNVLVATRLAFDGASAEEVVEVLERRDGDGLAAEARDLDLAGARRWFTSFGSCSIDEPFEDLVALGLLELS
>NC_008699.1|WP_011754130.1|694653_695829_-|fumarylacetoacetase
MRTWVPGAAGSGFDVDHLPYGVFSRAGEEPRVGVRIGDQVLDLAPVAAAEMLDVHRVLEERSLNALMAEGRRVRESVRAWVTGLLSDEAERDLVEPHLVPLAEVALHLPVEVADYVDFYASEHHASNVGRIFRPDAEPLLPNWKHLPVGYHGRAGTVVASGTPVVRPCGQRRGDAGPTYGPSTRLDIEAELGFVVGTPSELGTPVRYDAFADHVFGVVGLNDWSARDIQAWEYVPLGPFLGKSFATSVSQWVTPLEALDAAWVDLPGQDPEPLPYLGPGATRGLDIDVEVVVNGEVVSRPPYRTMYWSPAQLLAHLTVNGASLRTGDLYASGTISGPEPDQRGSLLELGWGADDAFLDDGDEVVLRYAAPGTSGGRITLGEVAGVIAPART
>NC_008699.1|WP_011754129.1|693163_694732_+|polyprenol-phosphomannose-dependent-alpha-1,6-mannosyltransferase-MptB
MLTRGFVGSVLVLLGGLVVSTLPRSTWLMGHDLLVDLRGAEAGRMAGLAVVLLGLGLLAAAWLSLCRHVAVAQGEEREDAVYLVRHAAVVWSAPLVLAPPLFSRDGWSYAAQGMLAHVGISPYEYGPGVLAGLPVAEAVDPRWMTTVTPYGPVPVAVGELAAGVTGNPWVLVVAHRLVALVGLALLAWAVPRLAQWSGLDPALASAVVLASPLMIANGVGGLHNDLLMVGLMAAALVAAVERGWVAGALLGGLAAAVKLPGGLVCVGVALVGLPLTASFAARVRRLAVVGLAAVGTLLGLGVASGLGSGWVHGLAVPATVNTPLSVTTLVGGLLDRLAWLLGLGLAPATFLGLVRQLGTAAMLVTVLVVALRWRTGDRAGAVQAVALVVATTVLLSPVVHLWYLLWVVPFVATLRLSRVATAGLLAASTGFGLVAPMDSSLHGAYYAIVLGSMLVAMLVPLLLLTRRSRARIERIVSAEWIPAAGSVAGVAVEPEPAQVRAGAMTPATSPSVIRPPDVPGAA
>NC_008699.1|WP_011754140.1|705813_706992_+|ROK-family-protein
MVENRETAAPATAGELLELVRTGRASTRSQLRALTGLSRTAVTARVGSLTSAGLLLLGEELASTGGRPPGALVFNKDAGTVLAAAIGRSRSQLAVLDLDGQELSADSRDHEVGVGPDELMADVVDRFRGLLAGVEPPVLGIGLSLPGTLDQARGVSIGSPVMSGWDGVPLAPYFADLAQAPLFVGNDADVLARSELLGGAGDLGDVLVVKASTGLGLGIIAGGRVLSGHLGAAGEIGHTKVDAAGELPCRCGAAGCLETIAGGWSLVAKMAEGGHPVGHVRELVALALQGDSAARGLLRDSGRELGDLLAVAINLLNPAAVVIGGDMGAAFDFYLAGVRESVYRRAAPLATRDLQFLPATHGARAGVVGCAALALDHVLSPVAIDSRLATQA
>NC_008699.1|WP_011754141.1|707009_708410_+|amidase
MTRVHAFGDDALGTLDAVGLVEAIQEGRVSIREVVDAAIARTERLQPELGALAYVAYDRARAEARDPRGGYFAGVPTFVKDNVDVARMPTQQGCDAYRARPVKHDGDFARMFLATGLVPLGKTQLSEFGFSPSAEHPRLGPVRSPWDTARTAGASSAGTAALVAAGAVPIAHGNDGGGSIRIPAAVNGLVGLKPTRDRLAQDRLTRRMPVRIVADGVLTRSVRDTAAFLREAEHVYRALSLPPIGDVTRPGRARLRIAVHTGGIGRTASPEVVDLTLKTARLLEELGHEVEQVVHPAPATVPEDFLLYWSMLAMTIVGAGRRHLGTSWDRTRLDNLTLGLDRHCRRRLHRLPGAIARLRRLSRVSADFHRRYDVALTPTLAQATPLIGHLDPTNDFDTVMERILEWVAFTPWQNATGDPAVSLPLATTSTGMPQGMMLSAGAGRESTLLELAYELEEAAPWPRITD
>NC_008699.1|WP_049774531.1|708399_709137_-|thioesterase-family-protein
MPTTAGPWSPDAQHGGPPAALLARAIERLPAAGGGRVGRFTMELLGPVPVGPVAVSARVVRPGRSVQLAAAELHDVARGRVAATAAAWLFPRTAGPGAGPAPLPHTPADGVAHPRPEAWHGGYLDAIEWRWVSGGLEVPGRGVVWMRPPALVEGEPISPVQRLLACVDSASGASAALDVREWGFLNTELTVHVLREPAGEWVCLDAETTLSDGSVGVATSATYDERGLVARSAQALLVVPRSVSP
>NC_008699.1|WP_011754143.1|709508_709679_+|50S-ribosomal-protein-L33
MASKTSDVRPKITLACVECKERNYITKKNRRNDPDRMELSKFCPRCRKHTAHRETR
>NC_008699.1|WP_011754144.1|709746_710715_-|hypothetical-protein
MLALALAAGAGCTGSRLPFPDHDDRRSGCGPLTYDEVRGRPPAYLGKPALDRFANDHAVCAGVWLRTGRGFVPQGVATAGWAAWVSGFDGDAPLHHRYCAITQVDLRTGRTMARLDPVAGQVGDRDPVTCRHGGGLVRDAHGLWLVETSRLWLIDPGTLDVRRVWALADPLRGSFALLDGDGRLGIGRWYPHRPGRVDWFDTDALVASTALDITPATAQRSTPAPRATQGAVWGALGGGRPGAWFVQSVTRCGVLVGPDGTRRRAFVPGAEGMSLAGRRSLWVVSESGTRHYQRLGGRPVVPMLVRLDLTDFASWTRPGCRV
>NC_008699.1|WP_011754145.1|710747_711149_+|MaoC-family-dehydratase-N-terminal-domain-containing-protein
MPVDQSLVGRVFPPTRPYAVTEEHVRSFVAATGGAYDGGPAPTTYPIVLAFEAMNAFLEAEAIELHRIVHGEQRFAYERPVVPGDVLTATLTVSSLRQIAGNDIIGTTSEVTDEAGALVCSTSATLVHRGAGA
>NC_008699.1|WP_011754146.1|711145_711529_+|MaoC-family-dehydratase-N-terminal-domain-containing-protein
MSAGSLPARTFTVTRADLVAYAEASGDHNPIHQDEAVARSVGLPGVIAHGMYTMALAARAVSEWFPGAQVVSLGCKFTNPVVVPASGGVDVEVAGEAEEADGVTTVKLTVTCAGQKVLGMPKAVLRA
>NC_008699.1|WP_011754147.1|711521_712544_+|UDP-N-acetylmuramate-dehydrogenase
MPDLADHTTLRLGGPAGRWVRATSEDELVAAVSEADGAGEPVLVLGGGSNLVVSDDGFPGTVVEVATRGVVPDVEDGASCGGVLVTVAAGETWDDLVALAVEREWSGIEALSGIPGSVGATPIQNVGAYGQEVAQTIASVRVWDRTLRGVRTFAGADCGFGYRTSRFKQDPGRHVVLSVTFQFRQGSLGAPVSYAELARAVGVEVGQRAPSAQVRRAVLSLRSGKGMVLDPADHDTWSAGSFFTNPVVPADAVPDGAPAWPQPDGRVKTSAAWLIEQAGFGKGYGAGPARLSGKHTLALTNRGSATTADLLQLAREVRDGVEARFGIRLVNEPVLVGCEL
>NC_008699.1|WP_011754148.1|712564_712987_-|DUF4190-domain-containing-protein
MSDPNQPGEPQQPYQQPYQQPYGAGQYQQPYQPGPGQPPYHWAPKPPEHPSATTAMVLGIIGLVGILLCGGVTLVVSPFAWAIGSRALREIDAEPGRYSGREMASAGRVMGIVGTGLLALAVVIVLAFIALFVGVATTSP
>NC_008699.1|WP_011754149.1|712983_714015_-|adenosine-deaminase
MRDLHELPKAHLHLHFTGSMRHSTLLELAERDGIVLPDQLVEDWPPQLSAADEKGWFRFQRLYDVARSVLRTEGDVRRLVLEAAEDDVRDGGRWLEIQVDPSGYAARFGGITAFTDLVLDAVRDAERATGLGMAVVIAANRTRHPLDARTLARLAAQYAGRGVVGFGLSNDERRGSTADFAPAFRIAERAGLLLAPHGGELRGPEHVRLCLDALHAERLGHGIRSAEDPALLDRIVSAGVALEVCPVSNVALGVYSDLTSVPLPTLLATGATVALGADDPLLFGSRLAGQYATMRAAHDLTDTQLAELARMSVRASRAPGDVRSRVLADIDAWLGASPATMGP

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Crispr_ID: NC_008699_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_14

1235754-1235838

Orphan

Consensus_repeat	Method
CGGTTTCCCCGGTTCACCGGGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_14

>merge|NC_008699|14|1235754-1235838|CRISPRCasFinder
CGGTTTCCCCGGTTCACCGGGGATGTTGGAACTTCTGGCCCGAAGTTTCGGCCCAACAGTTCCGGTTTCCCCGGTTCACCGGGGA

>NC_008699|14|14|1235754-1235838|CRISPRCasFinder
CGGTTTCCCCGGTTCACCGGGGA	TGTTGGAACTTCTGGCCCGAAGTTTCGGCCCAACAGTTC
CGGTTTCCCCGGTTCACCGGGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011754625.1\|1234885_1235731_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|334634
NC_008699.1\|WP_140403897.1\|1237501_1238419_-\|cyclase-family-protein	unknown	unknown	gnl\|CDD\|377240
NC_008699.1\|WP_011754620.1\|1229808_1231080_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379306
NC_008699.1\|WP_011754632.1\|1241055_1243371_+\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	unknown	unknown	gnl\|CDD\|224446
NC_008699.1\|WP_083768088.1\|1235871_1237227_-\|glycerate-kinase	unknown	unknown	gnl\|CDD\|376844
NC_008699.1\|WP_011754633.1\|1243525_1244791_+\|Tm-1-like-ATP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|179420
NC_008699.1\|WP_011754619.1\|1229447_1229738_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011754636.1\|1247422_1248148_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_008699.1\|WP_011754621.1\|1231159_1232068_+\|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	unknown	unknown	gnl\|CDD\|274584
NC_008699.1\|WP_011754629.1\|1238589_1239645_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176198
NC_008699.1\|WP_041546357.1\|1228525_1228756_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_140403904.1\|1246608_1247229_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_008699.1\|WP_011754618.1\|1229065_1229440_+\|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|239517
NC_008699.1\|WP_011754623.1\|1232805_1233030_-\|DUF433-domain-containing-protein	unknown	unknown	gnl\|CDD\|377269
NC_008699.1\|WP_083768089.1\|1245230_1246484_+\|3-keto-5-aminohexanoate-cleavage-protein	unknown	unknown	gnl\|CDD\|377562
NC_008699.1\|WP_140403898.1\|1239674_1240541_+\|FAD-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224238
NC_008699.1\|WP_011754631.1\|1240537_1241059_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NC_008699.1\|WP_011754624.1\|1233071_1234814_+\|VanW-family-protein	unknown	unknown	gnl\|CDD\|377286
NC_008699.1\|WP_011754622.1\|1232105_1232441_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011754617.1\|1228745_1229060_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011754625.1\|1234885_1235731_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|334634	pfam01674, Lipase_2, Lipase (class 2). This family consists of hypothetical C. elegans proteins and lipases. Lipases or triacylglycerol acylhydrolases hydrolyze ester bonds in triacylglycerol giving diacylglycerol, monoacylglycerol, glycerol and free fatty acids. Lipase EstA is a extracellular lipase from B. subtilis 168.	2.58254e-25
NC_008699.1\|WP_140403897.1\|1237501_1238419_-\|cyclase-family-protein	gnl\|CDD\|377240	pfam04199, Cyclase, Putative cyclase. Proteins in this family are thought to be cyclase enzymes. They are found in proteins involved in antibiotic synthesis. However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site.	1.33751e-22
NC_008699.1\|WP_011754620.1\|1229808_1231080_+\|ATP-binding-protein	gnl\|CDD\|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	7.65012e-30
NC_008699.1\|WP_083768088.1\|1235871_1237227_-\|glycerate-kinase	gnl\|CDD\|376844	pfam02595, Gly_kinase, Glycerate kinase family. This is family of Glycerate kinases.	5.24161e-137
NC_008699.1\|WP_011754633.1\|1243525_1244791_+\|Tm-1-like-ATP-binding-domain-containing-protein	gnl\|CDD\|179420	PRK02399, PRK02399, hypothetical protein; Provisional.	0
NC_008699.1\|WP_011754632.1\|1241055_1243371_+\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	2.6332e-152
NC_008699.1\|WP_011754636.1\|1247422_1248148_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.09718e-39
NC_008699.1\|WP_011754624.1\|1233071_1234814_+\|VanW-family-protein	gnl\|CDD\|377286	pfam04294, VanW, VanW like protein. Family members include vancomycin resistance protein W (VanW). Genes encoding members of this family have been found in vancomycin resistance gene clusters vanB and vanG. The function of VanW is unknown.	1.30762e-58
NC_008699.1\|WP_011754629.1\|1238589_1239645_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	4.60387e-91
NC_008699.1\|WP_140403904.1\|1246608_1247229_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.29438e-36
NC_008699.1\|WP_011754618.1\|1229065_1229440_+\|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	gnl\|CDD\|239517	cd03425, MutT_pyrophosphohydrolase, The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). This enzyme requires two divalent cations for activity; one coordinates the phosphoryl groups of the NTP/dNTP substrate, and the other coordinates to the enzyme. It also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as metal binding and catalytic site. MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides.	2.39082e-36
NC_008699.1\|WP_011754623.1\|1232805_1233030_-\|DUF433-domain-containing-protein	gnl\|CDD\|377269	pfam04255, DUF433, Protein of unknown function (DUF433).	2.1074e-19
NC_008699.1\|WP_083768089.1\|1245230_1246484_+\|3-keto-5-aminohexanoate-cleavage-protein	gnl\|CDD\|377562	pfam05853, BKACE, beta-keto acid cleavage enzyme. BKACE, beta-keto acid cleavage enzyme plays, a role in lysine degradation. In certain instances it catalyzes the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA. The family is found to have at least 14 slightly different potential new enzymatic activities, all of which can therefore be designated as beta-keto acid cleavage enzymes.	2.62991e-125
NC_008699.1\|WP_140403898.1\|1239674_1240541_+\|FAD-binding-domain-containing-protein	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	2.21078e-58
NC_008699.1\|WP_011754631.1\|1240537_1241059_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	1.14012e-63
NC_008699.1\|WP_011754621.1\|1231159_1232068_+\|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	gnl\|CDD\|274584	TIGR03445, mycothiol_MshB, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase. Members of this protein family are N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase, also called 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, the MshB protein of mycothiol biosynthesis in Mycobacterium tuberculosis and related species. [Cellular processes, Detoxification].	2.50226e-105
NC_008699.1\|WP_011754617.1\|1228745_1229060_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	1.63634e-19

>NC_008699.1|WP_011754625.1|1234885_1235731_+|alpha/beta-fold-hydrolase
MRLLLGALLVSLVAALGVSAPAGADGVPLPTNPFGDPTGANDWSCEPATQRPQPVIIVHGTFGDKKSLLDDLSAAMVADGFCVYSFDYGNRGTGDIPTSAKQLSAFTAKVLDATGADRVSMVGHSQGGMMPRYYIKFLGGASVVDDLVGLSPSNHGTTIVADPSNPLTGGLCPACNQQAAGSDFLTRLNAGDETPGRVSYTQISTRHDEVVVPYTSAFLAAGPRTTNVTIQDSCPADTAEHVFIPMSRTAIAWVLNALTRPGPADPAYRPTCGATGLPGAP
>NC_008699.1|WP_011754624.1|1233071_1234814_+|VanW-family-protein
MNQQPTVPAREKEGGKVVLLMLAGLVLLAGAAYGALYLAAGDKVPRGTTVAGVDIGGRTPADAEEVLRTGLADRVDRPITVAAEGARSTLDPGEAGLTVDYAASVAEAGGGRSWSPGRLWDYWTGGDDLDPVLDVDDAAFDAALDKLGEDLGTPPVEGDVKFRDGKVVVTDPATGEEIHPEAARLAITTAYIAEDATDVELELRPADPEVDAADLQEALEAFANPAMSGPVTLVFGDSPVRLDPADFGKVLGMGAEDGELVPDLREKKLVKLVDRGISQDGAPVDATVALVDGKPKVIPAKPGVTYKPSDVSDAFLELVAREGDREMKVPSTVAEPDFTTKDARALKIREQVSTFTTYYPYAEYRNINIGRAAELIDGTVLKPGDEFSLNGIVGERTRENGFTEGFIISDGIFKEDLGGGVSQMATTTFNAMFFAGLKDIEHKPHSFYIDRYPVGREATVAWGAVDLRFENDTPYGVLVHAHVTPATSSSQGVVTVSMYSTKYWDISTTTSDRYNYRQPATRTLTTPDCYPNTGYAGFDVDVTRTFRRHGEDAVDHTEKFHTAYTPSDTVICKKPKQRGD
>NC_008699.1|WP_011754623.1|1232805_1233030_-|DUF433-domain-containing-protein
MSTDRITVDPARMAGAPTIRDTRVTVTAVLGQLAAGSPVEQVLADYPYLEREDVLAALAFATESIQRDFPFVAA
>NC_008699.1|WP_011754622.1|1232105_1232441_+|hypothetical-protein
MRWLAALGLLVAGAVTGVAVVALHPIGWGLALGLVATGAVVAALPAGWWSRLAFVVGWDLLVGWLTFPRPEGDYVISQDLPGYTVLGAALVLIVVGIATLPRPRGCRGGEA
>NC_008699.1|WP_011754621.1|1231159_1232068_+|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase
MTFDQRLLLVHAHPDDESIGQGATMAKYAAEGRGVTLVTCTGGEMGEILVPELTHLAADQEDRLGEHRRGELDAAMAELGVTDHRYLGGFGTYRDSGMKWHEDGHAVPADDIHQNAFWHADLTEAADHLVAVIREVRPQVLVTYDQFGGYGHPDHIQAHRVATYAAALAAVPSYRKDLGAAWDIAKIYWGAMSESRMRAALRALREAGDTTAFEGMDPDGPLPPFVTADEDLSAVVDAQEHVEAKLAAMRAHATQITTDGPFFALSNNVGNVAWGLEFFRLAKGERGELNQDGLETDLFAGL
>NC_008699.1|WP_011754620.1|1229808_1231080_+|ATP-binding-protein
MPGYVRRIVDDELDDLLAGLAAISIEGPKGVGKTATAEVRATTTYRLDVPSELQVVQADPDRLVAGPQPILIDEWQHYPPSWDLVRRAVDRDPAPARFLLTGSASPSGAPTHTGAARIVPVRMRPLSLVERGIPASVSLGSLLSGRRGAISGATDITLRDYVDEILAGGFPGLRGLPARALRAQLDGYLQRVVDREFPEQGLTLRHPDTLRAWMRAYAAATSTTASFEVIRDAAMPGVGNKPAKSTTVPWRDILARLWLLDPVPAWLPTTNLFKELASADKHQLADPALAARLLNVTAEKLLAGESVGPQVPRHGTLLGALLEGLVALNLRVYAQAAEAEVRHLRTHRGEHEVDFIVTGSDGGVVALEVKLSATVADTDLTHLRWLASRLGNDLRDAVLVNTGTHAYRRADGIAVVPVALLGP
>NC_008699.1|WP_011754619.1|1229447_1229738_+|hypothetical-protein
MRGIFFDEDDARAVVARLIALGYDAHAERDRLAGEDDDEDHPWAVLTDAPAVELELLVEQYDGWLDDDAPAPPAPPPLDLPSGPRRIKRSGRTGSV
>NC_008699.1|WP_011754618.1|1229065_1229440_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase
MVGAAILRDGRVLAARRTFPAEAAGRWELPGGKVEPGETPEDALVREVAEELGCTIELTGWLPEEVAIGDRHVLRVALARLVADEPTPHEHDRVRWLGADELEDVDWLDPDRPFLLAVRAALLG
>NC_008699.1|WP_011754617.1|1228745_1229060_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MRGDVFELRVPRGSQGHEQRGRRFAVVVQSDLLPLSTWLVAPTSSSARASGFRPEVEVGGTVTRVLVEQTAAVDPQRLGDLVGHLTGAELDEVDRSLRIVLGLE
>NC_008699.1|WP_041546357.1|1228525_1228756_+|hypothetical-protein
MATITFRTDPEVDAALAALVVEGRDRSRAIREAIIEAARRERDDRLRAEATALAADPEDRAEARAVIEDMESLRAW
>NC_008699.1|WP_083768088.1|1235871_1237227_-|glycerate-kinase
MLGRGRFPGRDAGGDPERCQDRSDVPGRRRVRGARGDGVRSSQPRRRSPRQAPARADRPGGPRPGAECHRLPDPGGSLPGRRSAVSRVRRVIVAPDKFKGSLRAAEVADLIAGALAQRPGFEVVRHPVADGGEGTVELALGLGFDPVAVEVTGPLGRPVPTTFAMRDGTAIIEMASAAGLAVLPVAPDPRTAWSATTYGVGELILAAVSRGATHVVVGAGGSATTDGGAGAVAALGIEVAALGHHPHRGGPPRIRPDGQLGEVDLVVACDVDNPLTGAEGAARVYAPQKGADPPCVAALEARMTAWADAVAKATGRDLRHLPGAGAAGGLGFGLVALAGARLASGTELLLELTGFDVVAASADLVIVGEGSLDRQSLRGKGPVGVARASAARGAAVIAVTGRNELSELEEGEAGLSRVYSLSDLESDPAVCMREARRLLRAVAARIAEDWG
>NC_008699.1|WP_140403897.1|1237501_1238419_-|cyclase-family-protein
MSSTPFPEAPEGLRHVGPAGHQSPADVLAALRLPEQGRVFSLALPRYTGMPLFGSHPPFQVTMYRTPAGLRGDGVEPWGPHNEVNLQYMAENVSGTAHSGAHVDALAHMTIGEDDHWYGGGNAQEHLGDRGPTVGDGSRLPPFIRRGVLLDVPGYLGVDALPSHQPVDAAQLQAVARHQGVTVRRGDVVLVRTGYLSAWPDTDRMARHTTAGPDLSAARWLLEQGVVATGSDTETYEVQPAPDPGSPANPQPVHTLLLIEHGIYLFEGIYLEELAAEHVHEFLFVALPLKIKGTTGSMLDPVAII
>NC_008699.1|WP_011754629.1|1238589_1239645_+|alcohol-dehydrogenase-catalytic-domain-containing-protein
MTQIMQALVVREPNVLEIAEVPVPEPGRNEVLARVRSVSICGTDAHLINGDYPGFWPPQFPFTPGHEWAGDVVALGEGADTFGWRVGDRVAGTSHSACGACQKCVEGQYNLCENYGRPALHAQYGHNAQGVNATYAVHNVKSIFRLPDEVSFDVGALADPASIALHVARRGNIKPGDTVAVTGAGAIGLLAADAALIDGAARVIVVGRGHRLERAAALGFETVDTRTGDPVAEVRGLTSGLGADVVLECAGVPETLIWGMAMLRRGGRCAMVGIPTEDVSLKCQPLVLDELELVGSRASAGEMRRVLPFIANGRMRAEELITHHFPLSEYDKALATFNDRASGAIKIIVNP
>NC_008699.1|WP_140403898.1|1239674_1240541_+|FAD-binding-domain-containing-protein
MVRYYRPATTAQAVAALAGQPHASRILVGGTDLLVAVRHRRAQPTLVVDIKRVRDLVPPITVDEQGITFGPTATMSNVIADPTVREWFPALVEAAALVGSVAIRNRASLIANSANGSPAADTSPPLVSLNASVTISSVSGERTSPLREFFVAPRRTRCEPGEMVTSLRVPRPAPGSSSAFERMTRRRGVDLATCSVSAVVDADGAMTVGLGALGPTTLLGGPVAPIDLTSQEQLEQAIDALLAPATPIGDVRAGKPYRTAMARVLARRTVLRAAGRRTDPDRQTGRSS
>NC_008699.1|WP_011754631.1|1240537_1241059_+|(2Fe-2S)-binding-protein
MIPTADPSADDVGADLVAVTCTVNGRSAGFSVPPHRTLMDTLRYELGLTGTKTCCAEGECGACTVIVDGVTVNSCLMLAAEAEGCDILTVEGLGAGEPSGLCDLQESFLQTGAVQCGFCIPGQVMAAEHLLRANPDPSVEEIREGMSGNLCRCAGYQRIVAAVELTSRKRATR
>NC_008699.1|WP_011754632.1|1241055_1243371_+|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit
MIEQQGSEREALRTVGEPIRRYGGAARVAGQQEFLADLHFPDAAAVALVTLPVACASVTGVDGKRAMEMPGVIAVVSAADLPQPVPRFGISHQDRPVLADGEVLFHGEPVAAVVAETLDQAEAGAREVEVTFEEKTGVYTVDGALAAGAPLVRDPSLRPVEDENRDSNVLETALYEWGDTVAAAGEAAVIVENTYTFPMVTHFPIEPGGTVAVPTGAGGLDIYSPVQHPYLLQRTIATVTGLPLSQVRVFAPDPGGGFGGKQTPRLEPLLAFLALRTGRTCRLVLSLEQTFQMMRRAACRVQARTGFAGDGALIFHELECDFLIGAYADVAPRVMTKGSYVGAGPYRIPRVRTASRAVLSNTTPSTAFRGFGAPQVAWATESQLDAGARALGLDGLQIRRRNLVNMGEAFFRGPYEATADGHWHEALEKAAELVGWGQPLAPGRGRGIAVAIKPGATSGLSQSLVRFLADGSAIAYAGTSDMGQGARTLWQQILADELGSPLDKIRVVSGDTGVVPFDLQTSASRSTVFMGNAVLEACRDIRKRVLALYAESTGIDEELLSEAPGVLITPDGELTLLEASRIALGALGGEFVGQGTARMRGRKGHPLGGDAAFYEFNCTAIEVEVDLETGELLLHRHVSVSDVGTELNPIQVTSQDEGASIMGLGHSQMEQLLLDDHGVIRNLGALDYRIPTFKDVPVELITHGIENHDGPGPYGSKGISEGALLCTAGALGSAVSDAIGTPIRDLPLTPERVWTALHPDVTGRPGGEEHT
>NC_008699.1|WP_011754633.1|1243525_1244791_+|Tm-1-like-ATP-binding-domain-containing-protein
MERKAVVCLAGTLDTKGAEYAYVKDCLLAAGVDVHVIDCGVLGEPGFTPDVDAVQVAERAGIRLEDFQSGVEGAGGRVLAVTKMSEGLQQVLEELVSQDRIDAVVGLGGTGGTDLLSGAFKNLGLGFPKLIVSTMASNNTRPYVGHSDLHMANAVTDIAGLNSISKQVLGNAANGVAGMAMGRARIRAQAEASKPLIAVSMFGVTTPGVMRVRSRLEAEGFEVVTFHAVGEGAGMEHLIDQGAIDGLIDYTLPEVLNHWNHGIFDPGCERMEAAIRSGIPQVVVPGAMECFNFGAVDTIPAEFNTPERNVLVHNPNITSLLATPEELVKLGEYLAEHVNQAPGPKAVGLPLGGLDNYFKEGSQWHGVDVTPLFDAVRRTLDPGIELIEMESNINDAEFADAIFDLFMKQWAAREQPAAAVG
>NC_008699.1|WP_083768089.1|1245230_1246484_+|3-keto-5-aminohexanoate-cleavage-protein
MAGTPGAGGVLGRSPLAPGRHRGSRGPEDPGVRREPCRRAGLAWQDDRRRHPLPGPAGPGATAARRRPRRAGPGHRLPVVGRVRLGRHRGRRARDVVKTVRREGGSVPDAIITCAPTGAIHTPSMSPYLPVTPHEIAAAALAAADAGAAIVHLHVRDPDDGHPVQDTGLFRELLAEIQGKSDVVINLTTGGSPHMTVEERIEPAIALAPELASLNMGSMNMGLFPMLDRFPDLDHDWERRHLGNKDLVFKNTFADIERILRTCGDQGTRFEFECYDTAHLYNLAHFLDRGLVEPPLFIQTVVGLLGGIGADAEDLLHLRRTATRLFGDQFEWSTLGAGAAQIRVGTIALALGANARVGLEDSLWDGPGRLAESSRAQVERLRAAAAVLYRDIATPSEARRRLALRSAERSSGPGGES
>NC_008699.1|WP_140403904.1|1246608_1247229_+|GntR-family-transcriptional-regulator
MSGYYKPGERIIELQLSKELGTSQSPVREALRDLAAIGIVTIHSRRGARVRLPTRKELSDISVVRSEIDALAATLAAPLLDEDVLGQLRETYAEMQRHHAAGDHVALTQADAQFHRLIVTTSTNQAIEHVFDQLEPFARTFITLTLPKANVTSIIGEHKLILDALERGDATLAARHAREHQLNVSALFRDLFEDEERTAGTDPGGK
>NC_008699.1|WP_011754636.1|1247422_1248148_+|GntR-family-transcriptional-regulator
MSSSDPLTRSVLADQVKEWLLEAILGGAYPPDSRIVETAVAKELGTSQAPVREALRGLEALGIVEIAPFRGARVRRLEAAELLEAYVVRCTIEVLGARLAMARLTDEDIAGLLEIGEQMQSAADASDGRALAVVDASLHGRIMELAGNRTLLRVWRSLEPISRTYITLAGPGSDPQWTAGLHTPILDAIRLRDTDGVVHAIESHFDEIRDWLADHLAEVVEQQAAGTSGRTDTMSAGRGHD

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Crispr_ID: NC_008699_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_15

1283015-1283099

Orphan

Consensus_repeat	Method
TCCCCGGTGAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_15

>merge|NC_008699|15|1283015-1283099|CRISPRCasFinder
TCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCGAAGTTTCGGGCAAGAAGTTCCAACATCCCCGGTGAACCGGGGAAACCG

>NC_008699|15|15|1283015-1283099|CRISPRCasFinder
TCCCCGGTGAACCGGGGAAACCG	GAACTGTTGGGCCGAAGTTTCGGGCAAGAAGTTCCAACA
TCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011754675.1\|1286718_1286964_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NC_008699.1\|WP_011754673.1\|1284628_1285105_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011754669.1\|1281069_1282653_+\|leucyl-aminopeptidase-family-protein	unknown	unknown	gnl\|CDD\|238247
NC_008699.1\|WP_140403906.1\|1289070_1290384_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_140403905.1\|1277860_1278274_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_041546365.1\|1284005_1284632_+\|RNA-polymerase-sigma-factor-SigE	unknown	unknown	gnl\|CDD\|236606
NC_008699.1\|WP_082574674.1\|1280896_1281064_+\|DUF3117-domain-containing-protein	unknown	unknown	gnl\|CDD\|371461
NC_008699.1\|WP_011754663.1\|1276793_1277525_+\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|224527
NC_008699.1\|WP_011754670.1\|1282649_1282988_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011754667.1\|1279128_1279923_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|236163
NC_008699.1\|WP_011754674.1\|1285151_1286567_+\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NC_008699.1\|WP_011754677.1\|1287778_1289092_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349765
NC_008699.1\|WP_011754664.1\|1277531_1277834_+\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|274639
NC_008699.1\|WP_011754680.1\|1290898_1292350_+\|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	unknown	unknown	gnl\|CDD\|274360
NC_008699.1\|WP_011754662.1\|1275727_1276792_+\|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl\|CDD\|237264
NC_008699.1\|WP_041546364.1\|1283110_1283761_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NC_008699.1\|WP_011754676.1\|1287100_1287775_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011754668.1\|1279977_1280754_-\|PaaX-domain-containing-protein,-C--domain	unknown	unknown	gnl\|CDD\|225864
NC_008699.1\|WP_011754679.1\|1290411_1290777_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_049774264.1\|1278318_1279074_+\|DUF2817-domain-containing-protein	unknown	unknown	gnl\|CDD\|349475

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011754675.1\|1286718_1286964_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	7.9754e-12
NC_008699.1\|WP_011754669.1\|1281069_1282653_+\|leucyl-aminopeptidase-family-protein	gnl\|CDD\|238247	cd00433, Peptidase_M17, Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and play a key role in protein degradation and in the metabolism of biologically active peptides. They do not contain HEXXH motif (which is used as one of the signature patterns to group the peptidase families) in the metal-binding site. The two associated zinc ions and the active site are entirely enclosed within the C-terminal catalytic domain in leucine aminopeptidase. The enzyme is a hexamer, with the catalytic domains clustered around the three-fold axis, and the two trimers related to one another by a two-fold rotation. The N-terminal domain is structurally similar to the ADP-ribose binding Macro domain. This family includes proteins from bacteria, archaea, animals and plants.	5.17711e-165
NC_008699.1\|WP_011754677.1\|1287778_1289092_+\|hypothetical-protein	gnl\|CDD\|349765	cd03111, CpaE-like, pilus assembly ATPase CpaE. This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains 7 genes: pilA, cpaA, cpaB, cpaC, cpaD, cpaE and cpaF. These genes are clustered together on chromosome.	1.70343e-10
NC_008699.1\|WP_041546365.1\|1284005_1284632_+\|RNA-polymerase-sigma-factor-SigE	gnl\|CDD\|236606	PRK09647, PRK09647, RNA polymerase sigma factor SigE; Reviewed.	1.46954e-110
NC_008699.1\|WP_011754674.1\|1285151_1286567_+\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	7.15192e-90
NC_008699.1\|WP_011754663.1\|1276793_1277525_+\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|224527	COG1611, COG1611, Predicted Rossmann fold nucleotide-binding protein [General function prediction only].	5.34029e-52
NC_008699.1\|WP_011754667.1\|1279128_1279923_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|236163	PRK08140, PRK08140, enoyl-CoA hydratase; Provisional.	3.59219e-82
NC_008699.1\|WP_082574674.1\|1280896_1281064_+\|DUF3117-domain-containing-protein	gnl\|CDD\|371461	pfam11314, DUF3117, Protein of unknown function (DUF3117). This family of proteins with unknown function appears to be restricted to Actinobacteria.	4.53331e-23
NC_008699.1\|WP_011754664.1\|1277531_1277834_+\|DivIVA-domain-containing-protein	gnl\|CDD\|274639	TIGR03544, cell_division_initiation_protein_DivIVA, DivIVA domain. This model describes a domain found in Bacillus subtilis cell division initiation protein DivIVA, and homologs, toward the N-terminus. It is also found as a repeated domain in certain other proteins, including family TIGR03543.	1.42201e-10
NC_008699.1\|WP_011754680.1\|1290898_1292350_+\|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	gnl\|CDD\|274360	TIGR02946, Putative_diacyglycerol_O-acyltransferase_Mb3115, acyltransferase, WS/DGAT/MGAT. This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity].	5.04217e-131
NC_008699.1\|WP_011754662.1\|1275727_1276792_+\|succinyl-diaminopimelate-desuccinylase	gnl\|CDD\|237264	PRK13007, PRK13007, succinyl-diaminopimelate desuccinylase; Reviewed.	0
NC_008699.1\|WP_041546364.1\|1283110_1283761_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	3.06048e-58
NC_008699.1\|WP_011754668.1\|1279977_1280754_-\|PaaX-domain-containing-protein,-C--domain	gnl\|CDD\|225864	COG3327, PaaX, Phenylacetic acid-responsive transcriptional repressor [Transcription].	2.64272e-48
NC_008699.1\|WP_049774264.1\|1278318_1279074_+\|DUF2817-domain-containing-protein	gnl\|CDD\|349475	cd06904, M14_MpaA-like, Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins. Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A (MpaA) and related proteins. MpaA is a member of the M14 family of metallocarboxypeptidases (MCPs), however it has an exceptional type of activity, it hydrolyzes the gamma-D-glutamyl-meso-diaminopimelic acid (gamma-D-Glu-Dap) bond in murein peptides. MpaA is specific for cleavage of the gamma-D-Glu-Dap bond of free murein tripeptide; it may also cleave murein tetrapeptide. MpaA has a different substrate specificity and cellular role than endopeptidase I, ENP1 (ENP1 does not belong to this group). MpaA works on free murein peptide in the recycling pathway.	1.57183e-40

>NC_008699.1|WP_011754670.1|1282649_1282988_+|hypothetical-protein
MKGLTVRWSLADAPAGVEEQLASYVADSSHARFTGQPGLRFKTWRCRPGEWFEGCYVFVSDEARAAFQEAFSQTAAESPGSQIIGSAPILIEECDIVAVAEGGDGFLAAGRY
>NC_008699.1|WP_011754669.1|1281069_1282653_+|leucyl-aminopeptidase-family-protein
MPATPSSAPSSAPSSPALPSQVSPPEFALSAALPHAILGVEVVALPVLPGDDGGPVALGPGAAELGEQLGLDLLAYLEGDGATGAAGEILSVPVPLGTPDNAGLRCVLLAGVGAQTAADLRRAGAALARATYDRRSLATTVPAIAPDDGLEAFVVGAMLGSFGFSWRSGPPPHQPVKRVVLAGLPDPRPLAPVLDRAVAIGGAGWRSRLLATVPSNLKNPPWLADQAEQIGREAGLEVTVWDEHRLAEEGFGGLLGVGRASATPPRLIRLDYSPRKAGRRTPTVALVGKGITFDTGGLSIKPGEAMVNMKRDMTGGAVVLATMAALSAVDCPVRVVGLVVAAENAIGGDALRPGDVIRHYGGRTSEVTNTDAEGRLVLADALAYAVAEVKPDAVVDVATLTGAMKVALGQRTGGLFANDDALAATLVAAAERAGEPLWRFPLASVYEPKLSSTVADADNAPSGPGAIVAALFLQHFVGDLPWAHLDIASAGDSPDERHEWTTGPTGFGARALLAWLGTGHPLEGVGS
>NC_008699.1|WP_082574674.1|1280896_1281064_+|DUF3117-domain-containing-protein
MAAMKPRTGDGPLEVTKEGRGIVMRVPLEGGGRLVVELNAEEAGALGDALKDVVG
>NC_008699.1|WP_011754668.1|1279977_1280754_-|PaaX-domain-containing-protein,-C--domain
MQARSALFDVYGDHLRARGSEAPVAALVRLLDPVGIAAPAVRTAISRMVMQGWLEPVQLDGGRGYRTTTRADRRLDETGRRVYRRDAPAWDGHWHLAFVSPPPGRAARARLRAGLTFIGYAELADHVWVTPFERTELGSVLDRERASATTARADRFDPPPTGAWDLAALRLAYEGWLQAADDLVEQHLAAHEDPDEAAFAARFHLVHEWRKFLFTDPGLPDALLPRDWPGHAAAELFAGAAGRLKPGADRFVARCLGD
>NC_008699.1|WP_011754667.1|1279128_1279923_-|enoyl-CoA-hydratase/isomerase-family-protein
MTEPSVLLDVTDGVGTITLNRPDAYNSLDVATKELLLETVRAVADDPAVRCVVLTGSGRAFCTGQDLKEHIELLENGGSDLLFTTVDKHYNPIVTTLAGMAKPVVAAVNGVAAGAGASLAFACDLRILADTAGFNLAFANVALSCDTGASYHLQRLVGRAKALELLYFPSTVPAADALELGLATRVVPADELAAEVGALASRLAAGPTVALGAMRQSVAYAAGHSFEESLELESAMMQKTGATADHRAAVAAFVAKQKPVFEGR
>NC_008699.1|WP_049774264.1|1278318_1279074_+|DUF2817-domain-containing-protein
MRLGTLLATALTVTLATGLLAGVPTASYAVRAPDDRPAVKEVRVIGHSVRGRPIKAFRLGERGRPKALLISTMHGNEGHPRQILATLRDGRPIHGLNLWVLPIYNPDGLARHTRKNAHGVDLNRNFPYRWADLDGSYESGPRPGSEPETRAVMKFLKQIKPRWIVSFHQPLHGVDTDTKNARFSRRVADKLNLPRKSFTCGGVCHGTMTGWYNHQFRGSALTVEYGAHPSTRLMRRIAPKQVLSIWGARRG
>NC_008699.1|WP_140403905.1|1277860_1278274_+|hypothetical-protein
MIVYVLTGLAAVVIVLTRLRLGRQDGGAGRLQMGSGLLNVHTGAGALALVLWLVFLVAGEDSAAGSETVGIIALALWWVVVVAGLLILVRWLPSRGRHASEGREDTWSEGPGLSILAHVGMLVGVGVFTWAYLTAAV
>NC_008699.1|WP_011754664.1|1277531_1277834_+|DivIVA-domain-containing-protein
MWFFAVLIVLALGGIAVVAAGRGAPLAEVYDDRPDAGVPAEGPVTAEDLRRVRFPLAVRGYRMSEVDALLDRLASQLENGRGPEDERPGSPPRHGGEPHA
>NC_008699.1|WP_011754663.1|1276793_1277525_+|TIGR00730-family-Rossman-fold-protein
MVRSKSKGPILQRRAQVDAVTTDQRLLDSRGSADWVHTDPWRVLRIQAEFIEGFGALAELGPAISVFGSARTPADHPAYAVGEEVGRKLVQAGFAVITGGGPGVMEAANKGASEAGGISVGLGIEVPWEAELNGWVDVGINFRYFFVRKTMFVKYSQGYIALPGGLGTLDELFEAMTLVQTQKITSFPIVLLGVAEWAGLLDWMGDSMLADGRIKQADLDSLLVTDDIDEAIAWIVAGRRDGE
>NC_008699.1|WP_011754662.1|1275727_1276792_+|succinyl-diaminopimelate-desuccinylase
MHRIDLTTDVVTLTERLVDIESVSRNEQAIADAVETALAAYPHLTVTRHGNTVVARTDLGRPERVVIAGHLDTVPVNDNLPARREGGLLHGLGTCDMKGGDAVILRLAATVTEPTRDVTYLLYDAEEVEAEHNGLRLLSLSHPELLAADFAILMEPSNAGVEAGCQGTLRVDVRTTGERAHSARSWRGVNAIHRAGEVLRRLEGYAARRPVIDGLEYHEGLNAVGIRGGVAGNVVPDECVVAVNYRFAPDRSEAEAEAFVREFFAGFDVTVTDSAPGALPGLDRPAAKAFVDAVGGEVNPKFGWTDVARFTGLGIPAVNYGPGDPVLAHKQEEHVPIEQIERCETRLRAWLEGR
>NC_008699.1|WP_041546364.1|1283110_1283761_-|O-methyltransferase
MTTPIKPASWSYAEAYVVEDDVLAAARSRAEEVGVVPIGPGGGAALRFLASVLDARAVVEIGTGTGVSGLWLLRGMRADGVLTTVDIEAEHQRLARQSFTEAGIAAQRARTISGAALDVLPRLTDGHYDLVFCDGDKAEYSAYLQEALRLLRPGGVVAFDNALWHDRVADPAQRDEDTVAIRELGRQVAEHDDLVAVLLPVGDGLLVAKKEWNPGA
>NC_008699.1|WP_041546365.1|1284005_1284632_+|RNA-polymerase-sigma-factor-SigE
MDTPVTPAAGGPADRPAEGVPSWEEIVEQHSDRVFRLAYRLTGNRHDAEDLTQEVFVRVFRSLSTYTPGTFEGWLHRITTNLFLDQARRKQRIRFDALSDERADRLTSSSPSPDAAYADRTFDDDIERALATLPPDFRAAVVLCDVEGLAYEEIAEILGAKLGTVRSRIHRGRAMLRSALAHRAPSAGRVRYAGPAAGPLLSGWGSAT
>NC_008699.1|WP_011754673.1|1284628_1285105_+|hypothetical-protein
MIGHHLGSRTSALLDGQLSTDETERAWAHVHGCHACRDLVEREGWIKTRLAGLSFEVAAPAAPAWLKGSLIDASAGCGSACLTMAAPADHRRRNLGLAAIGGGAVGAAVMGVLVFGVAPADAPTIDRRAPLTSITNTQAPRTPTPTVPAAHVTRQAKR
>NC_008699.1|WP_011754674.1|1285151_1286567_+|trypsin-like-peptidase-domain-containing-protein
MTQDEPRDDESTQPLAAAPLGPPPATPPATPAEPPAAPPAAPPVAPPAGPPAGPRPPSWLPPTVQSPPHRWAGLPPGAPYAGQQQPFGPSFGPPSGPPPGHLAPRGRVPGWLWPVVCVLALTLGLVGGALGGLAYDQLSEDEPGTVSSGLAGVDTVSEAPLSADNGSIEAVAARLLPSTVQISAEYEGQRGGATGSGFVLDRQGHVITNNHVVADADEADGPIQIVDQDGNRYPATVVGRSPVYDLAVLYSPKAKGLTPAALGASQELRVGEGVVAIGSPLGLSSTVTAGIVSALHRPVTTGDAGNDSSYINAVQTDAAINPGNSGGPLVNLRGQVVGVNSAIATTGGGIGGESGNIGVGFAIPIEQVRVTADQILRTGEAKYPVIGAQVQTGQNDGNGAEIDEVMPDTPAERGGLRKGDVIIEVEGERVTDGIALIVAIRTHQPGETVEFTILRDGQERTISLTLGAETG
>NC_008699.1|WP_011754675.1|1286718_1286964_-|helix-turn-helix-domain-containing-protein
MAGPRFLTLADVAEVLNTSSAQVYALVRRGDLPAIKIGGRGQWRVESAQLEEFIERMYAETRTFVDEHPYVESDTRSEADA
>NC_008699.1|WP_011754676.1|1287100_1287775_+|hypothetical-protein
MTRRPAQRPEIGGVAPVPPATRATRAGWRDPRLWVGVLIVAVSVVAGARLLAAADDTVSVWAVSGDAGPGAELDAGDLVAHRVRFADAEDLGRYFTLDDELPADLRLVRGVTAGELLPRSALGAADDGADTVELPVAVDVELVPPSVRAGSVVDVYLVGRGNRDHTGPALAGATVVDAPGIDTTFGSASGHRQLVLAVPQADAAAFLDQLGRTEAPVLTVVRRG
>NC_008699.1|WP_011754677.1|1287778_1289092_+|hypothetical-protein
MADRALVLIVASGAAWEPAALRRLGDHPGIVVLKRCVDIDDLLAAATAGQADVAVLGLDAPGLDRSAVDLLRKHGVRPVAIAPGGVTLDGGRLRAARIGVHRVVTDDDLDRLVETVLAEESPATAVRPPAPLGPPPAGPPSPPPSGPAPGTPALPGRVIAVWGPAGAPGRTTVATALAAETARRQRRTVLVDADPYGGAVAQQLGILDEVSGLLSAARLASSGQLEERFASVQRGIDPHLSVVTGLPRGDRWVEVRVGAIEHLLEVGREQAEVVVDTGFSLEEDAAPDFGTRPARNQMTLGALEVADEVVVVGAADPVGLSRLARGLVELRDLTAGRPVHVVVNRMRGTLGWSERDIAGMVHGFARVAGLHFLPEDQVAVDRALVSGRTLVEVGDSSLGRAVARLVDALSPRGSTGAPADLPAPGARRAQAQAANSR
>NC_008699.1|WP_140403906.1|1289070_1290384_-|hypothetical-protein
MTLAHGIGGAKDLPISPELAIAGASAALVVSFTVLAVAWRTPRYDAATSGRPAPTLLGRLVDSTGWRVACRVFGMVVFLWAAMAAVFGKDLVINPIFGIFYVWWWVGLVPLSVLLGPVWKAISPARTINLAFAKVSGSDPDRGLLTYPDRLGYWPAALGLFAFVWMELVYPFSTELGPVRLWCAAYVAVMLVGGALFGTTFYERADPFEVYSTLVSRLSVWGRRGDLLVVRSPLANLDTTPARPGLVAVVAVLFGSTAFDSFKDSTRWLSFVQSTDTSSYLLNNLALLAFCVGVGLVFVVGCVLTGLGDDLRRRELPNLLAHSVVPIIVGYIIAHYLRYLVEVGQLTLVQASDPFSDGSNYLGTGNLDPVYWLAYHPTFLANVKVLAVVVGHVLGVIAAHDRAIKILPPRHQLTGQLPLLFAMVAFTVGGLYLLFAA
>NC_008699.1|WP_011754679.1|1290411_1290777_-|hypothetical-protein
MRRVLASLAVLLSSLPALTACGGSDSPSDGADSGPEVVEVTIQGESVTPNGERVEVAVGQDVELDVTADAPGEIHVHSTPEQELEYEAGESTLTIKGIDKPGTVDVESHNLEKVIVQLEVR
>NC_008699.1|WP_011754680.1|1290898_1292350_+|wax-ester/triacylglycerol-synthase-family-O-acyltransferase
MTERLRPRDVAILAEESASTPMHNATVEIFEPGQSGFDYARLVRLVQERISFVPRYRQRVQPVPGRLANPVWVDDEHFDIGYHVRRSALPRPGTLDQLRDLVARIVSRPLDRSRPLWEMYFVEGLADGQVAILTKSHQVLVDGIETVDLGQVLLDKSPEPKELGADGWRARARPSPIALMAGAVHDSLTGPETVAETLLSTTGSVLRGAASSARSAGRVFDALANRSVAGDSPIIGPLSQQRRIVAVRTDLADYRKVREAHGGTVNDVVLATVTGALRAWLMTRGESMRGIRQIRAVVPVSVIDEELEATSLGSQIAAHFVDLPVWEASPVVRLHQVSYSFQAHKETGRAVGASRLASMSGFAPATFHAIGSRVATVERRRGYQLSVTNVPGPQAPLYAAGARMVSTYPVPPLLEGHPLAIGVTSYDGHVYYGLTADRDLLPDADLLGPCVQEALDELVDSASGSRSRAPRGRKKRQPPEEPS

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Crispr_ID: NC_008699_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_16

1306911-1307000

Orphan

Consensus_repeat	Method
TTCCCCGGTGAACCGGGGAAACCGGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_16

>merge|NC_008699|16|1306911-1307000|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCGAAGTTTCGGGCCAGAAGTTCCAACTTCCCCGGTGAACCGGGGAAACCGGAAC

>NC_008699|16|16|1306911-1307000|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCGGAAC	TGTTGGGCCGAAGTTTCGGGCCAGAAGTTCCAAC
TTCCCCGGTGAACCGGGGAAACCGGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011754691.1\|1306687_1306885_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213197
NC_008699.1\|WP_083768092.1\|1296449_1301429_+\|NAD-glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|377452
NC_008699.1\|WP_011754692.1\|1307022_1307910_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_008699.1\|WP_011754701.1\|1315047_1315659_+\|S26-family-signal-peptidase	unknown	unknown	gnl\|CDD\|119398
NC_008699.1\|WP_011754690.1\|1305287_1306688_+\|amidase	unknown	unknown	gnl\|CDD\|171524
NC_008699.1\|WP_011754689.1\|1303272_1305132_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_008699.1\|WP_041547222.1\|1312521_1313226_+\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|226309
NC_008699.1\|WP_011754693.1\|1307959_1308550_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_008699.1\|WP_083768093.1\|1308548_1309496_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235962
NC_008699.1\|WP_011754684.1\|1294590_1295073_-\|DUF2505-domain-containing-protein	unknown	unknown	gnl\|CDD\|378476
NC_008699.1\|WP_140403907.1\|1301596_1303276_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_008699.1\|WP_011754695.1\|1309597_1310359_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NC_008699.1\|WP_041546367.1\|1295072_1295552_-\|DUF2505-domain-containing-protein	unknown	unknown	gnl\|CDD\|378476
NC_008699.1\|WP_011754696.1\|1310488_1311484_-\|Ku-protein	unknown	unknown	gnl\|CDD\|238408
NC_008699.1\|WP_011754686.1\|1295670_1296474_+\|tryptophan-2,3-dioxygenase	unknown	unknown	gnl\|CDD\|188272
NC_008699.1\|WP_041546370.1\|1311577_1312504_+\|non-homologous-end-joining-DNA-ligase	unknown	unknown	gnl\|CDD\|236599
NC_008699.1\|WP_011754699.1\|1313225_1314140_+\|non-homologous-end-joining-DNA-ligase	unknown	unknown	gnl\|CDD\|240133
NC_008699.1\|WP_011754683.1\|1294387_1294606_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011754700.1\|1314297_1314819_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_041546366.1\|1292748_1294377_+\|L-glutamate-gamma-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143441

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011754691.1\|1306687_1306885_+\|hypothetical-protein	gnl\|CDD\|213197	cd03230, ABC_DR_subfamily_A, ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A. This family of ATP-binding proteins belongs to a multi-subunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding protein and one or two integral membrane proteins. Eukaryotic systems of the ABCA subfamily display ABC domains that are quite similar to this family. The ATP-binding domain shows the highest similarity between all members of the ABC transporter family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	5.39591e-07
NC_008699.1\|WP_083768092.1\|1296449_1301429_+\|NAD-glutamate-dehydrogenase	gnl\|CDD\|377452	pfam05088, Bac_GDH, Bacterial NAD-glutamate dehydrogenase. This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyze the reversible oxidative deamination of glutamate to ketoglutarate and ammonia.	0
NC_008699.1\|WP_011754692.1\|1307022_1307910_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.63618e-13
NC_008699.1\|WP_011754701.1\|1315047_1315659_+\|S26-family-signal-peptidase	gnl\|CDD\|119398	cd06530, S26_SPase_I, The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are translocated across biological membranes. The bacterial signal peptidase I, which is the most intensively studied, has two N-terminal transmembrane segments inserted in the plasma membrane and a hydrophilic, C-terminal catalytic region that is located in the periplasmic space. Although the bacterial signal peptidase I is monomeric, signal peptidases of eukaryotic cells commonly function as oligomeric complexes containing two divergent copies of the catalytic monomer. These are the IMP1 and IMP2 signal peptidases of the mitochondrial inner membrane that remove leader peptides from nuclear- and mitochondrial-encoded proteins. Also, two components of the endoplasmic reticulum signal peptidase in mammals (18-kDa and 21-kDa) belong to this family and they process many proteins that enter the ER for retention or for export to the Golgi apparatus, secretory vesicles, plasma membranes or vacuole. An atypical member of the S26 SPase type I family is the TraF peptidase which has the remarkable activity of producing a cyclic protein of the Pseudomonas pilin system. The type I signal peptidases are unique serine proteases that utilize a serine/lysine catalytic dyad mechanism in place of the classical serine/histidine/aspartic acid catalytic triad mechanism.	2.10806e-05
NC_008699.1\|WP_011754690.1\|1305287_1306688_+\|amidase	gnl\|CDD\|171524	PRK12470, PRK12470, amidase; Provisional.	0
NC_008699.1\|WP_011754689.1\|1303272_1305132_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.22591e-173
NC_008699.1\|WP_041547222.1\|1312521_1313226_+\|L,D-transpeptidase-family-protein	gnl\|CDD\|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	8.29982e-18
NC_008699.1\|WP_011754693.1\|1307959_1308550_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.48297e-06
NC_008699.1\|WP_083768093.1\|1308548_1309496_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235962	PRK07201, PRK07201, SDR family oxidoreductase.	1.40185e-133
NC_008699.1\|WP_011754684.1\|1294590_1295073_-\|DUF2505-domain-containing-protein	gnl\|CDD\|378476	pfam10698, DUF2505, Protein of unknown function (DUF2505). Members of this family are all Actinobacteria. The function is not known.	5.74682e-40
NC_008699.1\|WP_140403907.1\|1301596_1303276_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.73821e-137
NC_008699.1\|WP_011754695.1\|1309597_1310359_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	7.74218e-31
NC_008699.1\|WP_041546367.1\|1295072_1295552_-\|DUF2505-domain-containing-protein	gnl\|CDD\|378476	pfam10698, DUF2505, Protein of unknown function (DUF2505). Members of this family are all Actinobacteria. The function is not known.	2.6722e-38
NC_008699.1\|WP_011754696.1\|1310488_1311484_-\|Ku-protein	gnl\|CDD\|238408	cd00789, KU_like, Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku homologs are predicted to form homodimers. It is proposed that the Ku homologs are functionally associated with ATP-dependent DNA ligase and the eukaryotic-type primase, probably as components of a double-strand break repair system.	1.10935e-119
NC_008699.1\|WP_011754686.1\|1295670_1296474_+\|tryptophan-2,3-dioxygenase	gnl\|CDD\|188272	TIGR03036, trp_2_3_diox, tryptophan 2,3-dioxygenase. Members of this family are tryptophan 2,3-dioxygenase, as confirmed by several experimental characterizations, and by conserved operon structure for many of the other members. This enzyme represents the first of a two-step degradation to L-kynurenine, and a three-step pathway (via kynurenine) to anthranilate plus alanine. [Energy metabolism, Amino acids and amines].	1.0412e-69
NC_008699.1\|WP_041546370.1\|1311577_1312504_+\|non-homologous-end-joining-DNA-ligase	gnl\|CDD\|236599	PRK09632, PRK09632, ATP-dependent DNA ligase; Reviewed.	8.40544e-77
NC_008699.1\|WP_011754699.1\|1313225_1314140_+\|non-homologous-end-joining-DNA-ligase	gnl\|CDD\|240133	cd04863, MtLigD_Pol_like, MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-homologous end joining (NHEJ)-mediated repair of DNA double-strand breaks (DSB). NHEJ-mediated DNA DSB repair is error-prone. MtLigD is monomeric and contains an N-terminal Pol domain, a central phosphoesterase module, and a C-terminal ligase domain. It has been suggested that LigD Pol contributes to NHEJ-mediated DNA DSB repair in vivo, by filling in short 5'-overhangs with ribonucleotides; the filled in termini would then be sealed by the associated LigD ligase domain, resulting in short stretches of RNA incorporated into the genomic DNA. The MtLigD Pol domain is stimulated by manganese, is error-prone, and prefers adding rNTPs to dNTPs in vitro. The MtLigD Pol domain has been shown to prefer DNA gapped substrates containing a 5'-phosphate group at the gap.	7.04777e-135
NC_008699.1\|WP_041546366.1\|1292748_1294377_+\|L-glutamate-gamma-semialdehyde-dehydrogenase	gnl\|CDD\|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0

>NC_008699.1|WP_011754691.1|1306687_1306885_+|hypothetical-protein
MPAIAVADLTMTYGELRAVDGVRLQVGEGEFFGILGRGPAPMGILAAFAVVVTLVAARLFCWETT
>NC_008699.1|WP_011754690.1|1305287_1306688_+|amidase
MTDLSRAGVAETARLVAGGEASARGVVEHALARMEERDRGLNAISQLLVDAAIAEAQARDEALVAGGPIGPLHGVPVVIKEEIDVAGTVTTFGGEANSTPADADAEVVRRLRAAGAVIVAKTTMPEFGAFPFTESASRGVTRNPWDPSRTPGGSSGGTAVAVSAGMVPAGMGGDGGGSIRIPSASCGLFGLKPQRGRVTTAPHPHLWWALGTAGPLTRSVLDSALVYDAIRGNVAGDLYTAGGDEPFVAAAGREPGRLRIGWSVKPVTLGVRPDPVHVRAVEDTARLLTDLGHDVREVDPRYPDPTAAFVPQFFAGIRTEADQVEHFERLERRTRETYRLGSWVTPKVIDRALRTTEQVAAKANRVFEDVDVLLTPAIAHRPPRVGRLDGVGTVRASLRAMPSIAYAALWNVAGNPAASVPCGLAADGLPVAVQLVGRTDDEATLFSLSAQLEAARPWPLLAGDPA
>NC_008699.1|WP_011754689.1|1303272_1305132_+|ABC-transporter-ATP-binding-protein
MTTGPGSNTDDDTDVRRWRGVAEVDADEAAERMTAGRLGGGSGRLLRELLAPYRRAIQALVLIVVVENAARLSIPYLVKEGIDTGIPPIQESGDLEPLFLVVGAVLVATLVQALSRNLFLVRSGRIGQDVLFEVRRRVFRHFQVLSPAFHDGYTSGRVISRQTSDVDAIYEMLETGFDGLVTAALTLVGTAGILLLLDVKLGLVALLCGPFLAWLTNWFRKESARSYQVTREKVALVIVHFVESMGGIRAVQAFRREPRNQEIFDDVNDQYRAANLVAFRLVAWFMPGIRLIGNVTIALVLLYGGYRAYQGEVTVGVLAAFLLYLRQFFEPMMEISQFYNTFQSASAALDKLAGVLDQEPGVPEPQRPRDLPEARGELRFEHVGFAYVEGRPVLPDLDLTVPAGQTLALVGTTGAGKTTLAKLATRFYDPTSGRVLLDGVDLRELASDTLRDRVVMVTQENYLFSGSVADNIRFGRPTATREEVVAAARALGADDFIRTLPAGYDTDVSNRGGRLSAGQRQLVAFARAFLADPAVLILDEATSSLDIPSERLVQRALRTVLAGRTAVIIAHRLSTVEIADRVIVMEHGRIVEDGSPAELVAGGSGRFSDLHRAWLDSLA
>NC_008699.1|WP_140403907.1|1301596_1303276_+|ABC-transporter-ATP-binding-protein
MLLASLGGVGLSIAIPLVTKALIDGPITHHELRGLIGLGLLALALGVLEAVLVWWRRWVQSATVLDLETALRGDLYDHLQQLPMSFHSRWQSGQLLSRATTDLSAIRRFSGFGLIFLITNVLQLGVVTVVLLEMYWPLGLVVAATAAPIVWLSMRFERSYVLVSRRVQDEQGDLATLAEEGAVGIRVIKSFGRSEHVSAQYEAAARTLHATSMDKVRLSAKFWTFLEVIPNLAVVVVLLLGSIGVGKGYLTPGELVAFITLMLSLVWPVASLGVILAMAQEAMTAAARILEIFDTAPAIVTGTREIERPRGHVRFEHVDFAFPDAPGELVLRDVNLDIAPGETVALVGATGSGKTILTALVPRLYDVTAGRVTIDGVDVRELRLSHLRQLVATAFEEPTLFSMSARENLTLGRADATEEEIESALEVSQAGFARDLPWALDTRIGEQGMALSGGQRQRLALARAVLARPRVLVLDDTLSALDVHTERLVEESLRRVLADTTGLVVAHRASTVLLADWVALIQDGTVTHVGDHRELLATVPAYQELLAAEALDDTEGGAA
>NC_008699.1|WP_083768092.1|1296449_1301429_+|NAD-glutamate-dehydrogenase
MGTAQRAVGAPKRRLGGAVLVDGRRRPNVGPVSTTTREQDLSELLSEAAALARKGKGTGSPPHDAIDDLIRAYYRHVAPEDVCERSAVDVYGAFASHYRLAAERPQGTARVRVFTPTPGDQGWSAAGHSVVEVVVDDMPFLVDSLTMELSRQMRDVHLVVHPLFDVVRDITGQLREVNPGADATDSDETGRELGRESWMHVEIDRIPEGEDHGRIEESIQRVLRDVRESVEDWSKMHAQVADIVHELTVEPPDGVDAEEVREARDLLQWLAEDHFTFLGYREYHLERQDDGEHLRGVPGTGLGILRADQDMATSSGKLPAQAAAKAREKTVLVLTKANSRSTVHRPAYLDYVGVKKFENGEVVGERRFLGLFSSAAYTESLTRIPLLRDRATAVLKRIGFSPHSHDGKALMDTLETYPRDELFHTSVDELAPMAQAAMHARERRQLKMFIRRDTYGRYVSVLVYLPRDRYNTAVRERFSEILRESLGGDTVEFTVRLTESTTARVHFVVHPPKGSAIHEVDSADLERRLLEASRSWRDDFASAVLAEYGEEDGARLARRYLDSFPEAYKEDFPARIGALDLGRLEAVRVGENGAGLDLSLHQDLDAGQGEARLKVYRIGPPLSLSEVLPMLSSMGVEVVDERPYDLDGLERPTYIYEFGLRYERALPDDSRELFEDAIRAVWGGHNEIDGFNSLILGAGLTWRQATVLRAYAKYMRQGNSPFALDYIHDALSNNVDITRLLVLLFEIRFDPTADHTRAAKIEERITRALDDVASLDHDRILRSYLAHIRGTLRTNYFQASRDGGVRSYISFKLDPSGIPDLPEPRPRFEIFVYSPRVEGVHLRFGAVARGGLRWSDRRDDFRTEVLGLVKAQMVKNTVIVPVGAKGGFFCKQLPDPGDRDAWLAEGIACYKTFISGLLDITDNLVDGETVPPEQVVRHDGDDSYLVVAADKGTAAFSDIANGVAKDYGFWLGDAFASGGSVGYDHKGMGITARGAWVAVQRHFRERGVDCQTEDFTCVGIGDMSGDVFGNGMLRSEHTRLVAAFDHRDIFLDPSPDAAASYAERKRLFELPRSSWQDYDHALISEGGGVYSRSLKKIQLNDPVRSALGIASDVESMTPAELMRAILLAPVDLLWNGGIGTYVKSSEETNAAAGDKANDGIRVDGRDLRARCVGEGGNLGFTQLGRVEYALEGGPATADSGHGGRINTDFIDNSAGVDTSDHEVNLKILLDRVVKNGDLTEKQRNALLAEMTDEVADLVLRDNYEQNLALANAAANAGSMLHVHEEWVRRLERDGFINRELEGLPTSREVRRRLDRGAGLTTPEMSVLLAWTKIALAEELLVSDLPDDPYLDLDLRAYFPQPVQDGFGPQIHEHPLRREIIVTQVVNDIVNGAGITFWPRLSGETGATGAELTRANFVAREIFGSLPLRDDLRTLDNQLDAAVQTRMRLEMRTLVERASRWLVNNRRPPLDSQGTVDQFSGPVQRVMAELPDLMTGRELAAYQDRCERLEGEGVPSDLASRVAVLPPAYVLLGIVEVAAREELDPADVARVHFALGERLGLAALVQRILGLPRDDRWQTMARAALRDDLHDVHTQLTAQVLATTSADDPAPVRIAAWEDADGVLVPRAAATLEEICADDAADLARLSVGLRVVRGLLGTS
>NC_008699.1|WP_011754686.1|1295670_1296474_+|tryptophan-2,3-dioxygenase
MSDNFVSFGEQGAQLTYGSYLRLPQLLEAQHLESDPPAHDELLFITIHQVYELWFKQLLHEVSAARDAMLGGEAGGRLWWAQHLLTRVHVIERVLVQQIDVLETMTPQEFLEFRQRLAPASGFQSVQFRELEFLSGAKDPAYLERFRGITPAEKARLDARLSEPTLWDAFLAMLRSFGFAADSDAEVSAALRTAAHDRTRYAVVWALSEGLLQHDELAANWRARHVVMVERMIGSKSGTGGSSGSSYLRSRLPVQYYPLLWGLRSEL
>NC_008699.1|WP_041546367.1|1295072_1295552_-|DUF2505-domain-containing-protein
MRFRHELHYDAAPAAVFEMLADAAFREAACAAQDVISAEVTLERDGNGFTLSVDQEQRTDDLPSFARTFAGASTRAIQRETWTDTTGGTLQIDTPGKPSTLKGTITLRPEGSGTVEIVELEIKVKLPLIGGKLEHLLADKVTAGMDAEHGVGVEYLAGR
>NC_008699.1|WP_011754684.1|1294590_1295073_-|DUF2505-domain-containing-protein
MSRRLTHQMTYAAPLAQVVEMLADPRFREGVCEYQRVVSADVEIDRSGDAMTVLIEQVQPAAGIPSFAKKFVGDEIRIVQREDWSAPDTAELHVTIPGKPGHMDGTITLVESGGTTVETVDVEIRVNLPLVGGKIEGLVSDLLRKALVAEEKVGARYLSA
>NC_008699.1|WP_011754683.1|1294387_1294606_+|hypothetical-protein
MIPLHLGALHPVEQALTLILAFGPFALLGLVAWLRRRADRREDARTESTATSQTDSRVGSHAGSHAGGHADR
>NC_008699.1|WP_041546366.1|1292748_1294377_+|L-glutamate-gamma-semialdehyde-dehydrogenase
MDAVTHPPAPVNEPNLTYAPGTPERESLLVEIERLEKRQKSLRAYIGGRWKAGGGAEVAVVQPHDHQHVLGVLKNATQADARAAVKAAGEAAPQWRAMDFDDRAAILLKAAELLAGPWRQRLNAATVLGQSKTPFQAEIDAACELIDFWRYNVHYAREILADQPIANSRGIWNRTDHRPLEGFVYAITPFNFTAIAGNLPTAPALMGNTVIWKPSPTQQLAASLTMELLEEAGLPPGVINMLPGDGIDVSAVALAHPDLAGIHFTGSTPTFQHLWREVGNNIENYRSYPRIVGETGGKDFIVAHASADPDVLRTAMIRGAFEFQGQKCSAASRAYVARSVWTRMKDSFLAEIESITVGDPTDFSNFMGAVIDERAFAKHRKAIERAKRSRKLDIVVGGTLDDSAGWFVDPTVVEGGDPTDEMFTTEYFGPILAVHVFEDGDFEKVVRGMESIAPYALTGSVIAQDRRAIAWAQDELRFAAGNFYINDKPTGAVVGQQPFGGGRASGTNDKAGAAVNLLRWTSPRSIKETFVPPTDYRYPYLG
>NC_008699.1|WP_011754692.1|1307022_1307910_-|alpha/beta-fold-hydrolase
MASSGAQKRTIVRSIIRIGFGLLDRVAPGLGARLVIRIWFRIPRGMPLVAPTGAPFEVRWQGRTLRGQVWGEGPPVYLVHGWGGNGDQMRHFVEPLVAAGHRVVAYDGPSHGRSDAGRHGPETTDAVELAQALDAVVAEFGPARAVVAHSLGTLSLLLALRDGWFTAERVVLVAPVDGVPGFTAYFRRLLGFGDRVQRHTERLVEERTGYRPDELQTLLLAERPGLPEALVVQDRDDRSVGTGLARELAAGWPGATYLETRGLGHSRVLADPDVVASVVRFVADEVADARDELAS
>NC_008699.1|WP_011754693.1|1307959_1308550_-|TetR/AcrR-family-transcriptional-regulator
MSKGTETRAAILDEAADLASRVGLGGLTIGTLATQTGLSKSGLFGHFSSKETLQIGVLGRARERFVDRVLRPTVATPRGEQRVRALFEHWLAWQQGGLAGGCLFVDAVSEFDDQDGPVREELLRSERDKAESVMTIVATAVAEGDFAADLDLEQFAFELEGIMLTHHHSCRMLRVPDATDRARTAFERLVESARPR
>NC_008699.1|WP_083768093.1|1308548_1309496_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTQEKHDRSDVSTPARLVRPAPLRSWPMGLLLATPRARAARALRRLVHDPASPLAGRTVLVTGASSGIGEATAREVARAGATVLLVARRAEELERVRQEIEEAGGRASAYPCDLTDGDAVDALVAQVLAEHGVVDYLVNNAGRSIRRSLDLTQDRFHDFERTMAINYFGPVRLTMGLLPAMREQGFGHVVNVLSWGVQMKAPKFSAYLASKTALDTWSRIAGRETYGDGVTFTNIRFSLVRTAMSAPTEAYAGRGASPEQAAARVLRALEDRPVTLNTRAGDVGELLNILAPRLSDWLYHRFDAVFPDSKAARGD
>NC_008699.1|WP_011754695.1|1309597_1310359_-|VOC-family-protein
MSNVPGAPTWIELFAADTDTARTFYGELFGWTVQGSGPEYGGYAQFLRDGAPVAGLMRNEVGLPDTWSVYLRSTDVAATVASARQHGGQVVVEPMQVGDLGHMAVVADPSGAAVGVWQPLAFEGTAVRAEVGAPSWFELHTTDYPAAVAFYRDVFGWSTHQMSDTPEFRYTTLGRDDDALAGIMDATGHFDGAPSTWVFYVQVADADATVARAVELGGSLLPDSGPHDTPYGRLAVLADPAGVQLSVVGPNRG
>NC_008699.1|WP_011754696.1|1310488_1311484_-|Ku-protein
MRAIWKGAVSFGLVSVPVKLYAATESHDVSFRQVHAKDGGRIKYQRVCSLDGEEVAYADIAKGYETEDGEMVVLTDDDMAELPSTSSREIAVEKFVPSEQIDPMLFEKSYYLEPEKSGAKPYALLRQALLDADRMAVVTVALRQRTTVGVLRVKDADNGQVIVLQTMMWPDEIRTPDFVVDAGEVKPAEVKMANMLVETLAGDFDPAEFEDDYAEAVEALVKAKVEGGEVKRTPTSTKSSGEVVDLLAALQRSVDAAKSARGEETAAGPRDDSEEEAEDQTEPTKKTAAKKSAAKRAPAKKTAAKKSAATKAATKAPAKKAAKKAPARKAS
>NC_008699.1|WP_041546370.1|1311577_1312504_+|non-homologous-end-joining-DNA-ligase
MRPMLATHGRQVPTGEAWAHEVKWDGVRALTEVRDGALRMTSRNENAITIAWPELATSPLGDRDLLVDGEIIALNERGLPDFRTLQDRMHVRKAATAARLSREVPATYMVFDVLRIDGRDLTGEPLDVRRELLAGLGLDGTWQVPGSYDDGPMLFEATLQQGFEGIVSKRRSSRYAFGERSPHWLKFAHRHRVSYVVGGWRPQEGTADRLASLLVGEPTADGLLYRGRVGSGIGPKQGRALAELVARLGRPASPFADEVPRADAQGTRWLEPVLVVDIDTHGRGYQRLRQPSFQGVRSDLTPEDLCST
>NC_008699.1|WP_041547222.1|1312521_1313226_+|L,D-transpeptidase-family-protein
MSVGTPFVLAVALAATVLVAPPPAQAARDHVRLDGVDVRLRPGTTQVVTVNHTRGYRARVTWWVRTGEGWQKRMRATDGRIGYGGLVVGRHRRQGTGTTPLGTYDLPSAFGTHRARPGWDLDYRKIRKGDFWVQDNASDHYNRYRNKRQGGFRWWLPAGDPNSSERLSDYPVQYEWSIVTGFNGRQVRHRGSGIFLHVNGSGATAGCVSAPRWFIKSLMDRLDPDRKPVIAIGR
>NC_008699.1|WP_011754699.1|1313225_1314140_+|non-homologous-end-joining-DNA-ligase
MAQPEKEEVRVQVDGRTLTISNLYKVLYPRTGTTKGEVLNYYAQVAPTLLPHLAGRCVTRIRWPHGVHEGSFFEKNAPAGTPSWVRTAEVPTTGSRAQSSSDTLVFPIIEDLATLTWLVNLAALELHVHQWTVDRSGRPRGADRVVVDLDPGEPAGLHECCRVALMVRDRLAERGLAAKPVTSGSKGLHLYADLPERVPSEDSSALAKAVAEELQGEHPALVTATMTKARRAGKVFLDWSQNAGSKTTVSPYSLRGRELPTVATPLAWAEVEAGAQDPMALRQFRFDEVLERVQEHGDLFAGPR
>NC_008699.1|WP_011754700.1|1314297_1314819_+|hypothetical-protein
MTTTTAAATARKLILPVGSVVGAGLLAMLMGVPWTSAGEGASGIRLLADDHQGATLTISRIEPGESVSRSVTIRNSGGTPSRLSFQETGDPSPFADGELRLVIDQDGRTLYDGDFAAMSDIAQDVGTVESHGSSTFTFTVSLPDDAPFANQGDPASASYTWVNSTSGSSGSFG
>NC_008699.1|WP_011754701.1|1315047_1315659_+|S26-family-signal-peptidase
MEITTSPHRPASTPWGRLLALVVIVAPVSILVLLPIGLGLERYVMSGDSMDSGAAGGISQGSVVFERAVPVGDLRVGDVITFRPPAGAGVDGLVTHRIVSIGTDGIRTRGDAEAVRDPWVLHPKEPTLPRVVYTLPWVGYGYLVIFHPISRLLMAGSAVLLVLLITSEIRRRRGVAATGHDAPDQPEAPVPGAATRATEGSER

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Crispr_ID: NC_008699_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_17

1574651-1574736

Orphan

Consensus_repeat	Method
TTCCCCGGTGAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_17

>merge|NC_008699|17|1574651-1574736|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAACTTCCCCGGTGAACCGGGGAAACCG

>NC_008699|17|17|1574651-1574736|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCG	GAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAAC
TTCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011754952.1\|1577273_1577795_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NC_008699.1\|WP_011754947.1\|1571136_1572552_-\|FdrA-family-protein	unknown	unknown	gnl\|CDD\|180395
NC_008699.1\|WP_011754942.1\|1566839_1567379_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011754949.1\|1573277_1574594_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225306
NC_008699.1\|WP_011754954.1\|1580207_1580858_+\|carbon-monoxide-dehydrogenase-subunit-G	unknown	unknown	gnl\|CDD\|176853
NC_008699.1\|WP_011754943.1\|1567375_1567717_+\|MGMT-family-protein	unknown	unknown	gnl\|CDD\|226219
NC_008699.1\|WP_011754946.1\|1569721_1571140_-\|DUF1116-domain-containing-protein	unknown	unknown	gnl\|CDD\|377673
NC_008699.1\|WP_083768105.1\|1583391_1583637_-\|DUF2630-family-protein	unknown	unknown	gnl\|CDD\|378515
NC_008699.1\|WP_011754951.1\|1576434_1577277_+\|FAD-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224238
NC_008699.1\|WP_011754956.1\|1583772_1584438_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NC_008699.1\|WP_041546411.1\|1567826_1568825_+\|daunorubicin-resistance-protein-DrrA-family-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|130256
NC_008699.1\|WP_011754948.1\|1572548_1573202_-\|DUF2877-domain-containing-protein	unknown	unknown	gnl\|CDD\|378658
NC_008699.1\|WP_011754945.1\|1568824_1569634_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NC_008699.1\|WP_140403972.1\|1584484_1585900_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238618
NC_008699.1\|WP_011754950.1\|1574953_1576417_+\|nitrate-reductase	unknown	unknown	gnl\|CDD\|132655
NC_008699.1\|WP_011754955.1\|1581000_1582407_+\|amidase	unknown	unknown	gnl\|CDD\|236028
NC_008699.1\|WP_011754941.1\|1565520_1566843_+\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NC_008699.1\|WP_011754958.1\|1585896_1588017_+\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223
NC_008699.1\|WP_011754953.1\|1577799_1580211_+\|xanthine-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|376913
NC_008699.1\|WP_011754940.1\|1564501_1565524_+\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011754952.1\|1577273_1577795_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	2.59998e-67
NC_008699.1\|WP_011754947.1\|1571136_1572552_-\|FdrA-family-protein	gnl\|CDD\|180395	PRK06091, PRK06091, membrane protein FdrA; Validated.	3.59825e-132
NC_008699.1\|WP_011754953.1\|1577799_1580211_+\|xanthine-dehydrogenase-family-protein	gnl\|CDD\|376913	pfam02738, Ald_Xan_dh_C2, Molybdopterin-binding domain of aldehyde dehydrogenase.	0
NC_008699.1\|WP_011754949.1\|1573277_1574594_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	3.67112e-15
NC_008699.1\|WP_011754954.1\|1580207_1580858_+\|carbon-monoxide-dehydrogenase-subunit-G	gnl\|CDD\|176853	cd05018, CoxG, Carbon monoxide dehydrogenase subunit G (CoxG). CoxG has been shown, in Oligotropha carboxidovorans, to anchor the carbon monoxide (CO) dehydrogenase to the cytoplasmic membrane. The gene encoding CoxG is part of the Cox cluster (coxBCMSLDEFGHIK) located on a low-copy-number, circular, megaplasmid pHCG3. This cluster includes genes encoding subunits of CO dehydrogenase and several accessory components involved in the utilization of CO. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	7.24297e-49
NC_008699.1\|WP_011754943.1\|1567375_1567717_+\|MGMT-family-protein	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	1.42589e-17
NC_008699.1\|WP_011754946.1\|1569721_1571140_-\|DUF1116-domain-containing-protein	gnl\|CDD\|377673	pfam06545, DUF1116, Protein of unknown function (DUF1116). This family contains hypothetical bacterial proteins of unknown function.	6.31904e-120
NC_008699.1\|WP_083768105.1\|1583391_1583637_-\|DUF2630-family-protein	gnl\|CDD\|378515	pfam10944, DUF2630, Protein of unknown function (DUF2630). This bacterial family of proteins have no known function.	2.32602e-33
NC_008699.1\|WP_140403972.1\|1584484_1585900_+\|amidohydrolase-family-protein	gnl\|CDD\|238618	cd01293, Bact_CD, Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi, but not mammalian cells. The bacterial enzymes, but not the fungal enzymes, are related to the adenosine deaminases (ADA). The bacterial enzymes are iron dependent and hexameric.	2.06185e-89
NC_008699.1\|WP_011754956.1\|1583772_1584438_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	1.25807e-52
NC_008699.1\|WP_041546411.1\|1567826_1568825_+\|daunorubicin-resistance-protein-DrrA-family-ABC-transporter-ATP-binding-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	1.09095e-110
NC_008699.1\|WP_011754940.1\|1564501_1565524_+\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.80484e-96
NC_008699.1\|WP_011754948.1\|1572548_1573202_-\|DUF2877-domain-containing-protein	gnl\|CDD\|378658	pfam11392, DUF2877, Protein of unknown function (DUF2877). This bacterial family of proteins are putative carboxylase proteins however this cannot be confirmed.	2.20176e-23
NC_008699.1\|WP_011754945.1\|1568824_1569634_+\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	6.24417e-16
NC_008699.1\|WP_011754950.1\|1574953_1576417_+\|nitrate-reductase	gnl\|CDD\|132655	TIGR03616, Putative_pyrimidine_permease_RutG, pyrimidine utilization transport protein G. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the uracil-xanthine permease family defined by TIGR00801. As well as the The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40).	4.51536e-101
NC_008699.1\|WP_011754941.1\|1565520_1566843_+\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	4.94302e-24
NC_008699.1\|WP_011754958.1\|1585896_1588017_+\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	0
NC_008699.1\|WP_011754955.1\|1581000_1582407_+\|amidase	gnl\|CDD\|236028	PRK07486, PRK07486, amidase; Provisional.	4.6706e-155
NC_008699.1\|WP_011754951.1\|1576434_1577277_+\|FAD-binding-domain-containing-protein	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	7.80203e-58

>NC_008699.1|WP_011754949.1|1573277_1574594_+|helix-turn-helix-domain-containing-protein
MLISGDREELASAALAKVDALHTGLTQIVLEGGNLDGIAAEVARVLEVGVAFTSTDGRERASALPEDLRSALDSHDLVDPTGRLRVERMAGDGAPVETGEARSLRVAAGGVDLARLVCLRPDEPLSSDDVHALERAAAVAALLITREEAVTAVENKYQGDFLRDLLMRRGGLANDQAYVTEHAATFGWDLARPVVVVSAEIDPVPGEEPVGGVQRRQWQERFSAAWRQVSNGLGTGIPCVDFSSEVVTLLPLAGYGPEDDPGDRREDEPVAGHDVVRRAVTAVAGDKGGGRRSFSVGVSRVARTLDELPGAYAQARRAVEVGRRVSGWGSTTFFDQLGLHRLIALIPPEENGELRSFVRDVLGPLAEPTSEAADLRETLQVLLDTNFNVAEAARLQFFHYNTMRYRVSKLERLLGPLSTDPHLRLDVAVALRVLELAG
>NC_008699.1|WP_011754948.1|1572548_1573202_-|DUF2877-domain-containing-protein
MIPVSAPARVRARLHAAPDGPLPVVHRGRDAIYLDLAGSCVGVVGTRATAVPCALRTALDALDAGSARVTGGVLHLDDEPLVIGRIVDVTVPRLTAATTSGPAPLPGDVREMVGRGDGLTPYDDDVLCGWLAVHRGLGVPTPDADAAIRACVDRTTLLSATLLDCAMHGEVIPEFAAWVATPDDPDRTATLAAVGHTSGRGMLQGARFVLDHLRGAA
>NC_008699.1|WP_011754947.1|1571136_1572552_-|FdrA-family-protein
MTTPSPTHVELRPGAYADSVTLLQVSRVVQGLPGVLAAQVAMATPLNVEVLTGMGFEVPAQAGPNDLVVALRLEAADALPAALAGVDQALRDANRRDEGAATIAPPRTTASALRRTPDAVALVSVPGAHAFVEAMDAVEAGRDVMVFSDNVPLEQELALKRAAAERGVLVMGPDCGTAVVDGVGLGFANVVEPGPVGIVAASGTGCQQLLALLDHAGVGVTSALGVGGRDLSAEVRGLATREALRRLDEDPGVELIVLISKPPAADVTAEIEAYAAALATPVELALLGPGRPDLTAAAEAVLRRLGREVPAWPVDPPDVSPRVNPGALRGLFVGGTLASEAALVAGELLGEADGHTFVDFGDDEYTTGRAHPMIDPSIRLEHLARAAADPTTGVLLLDVVLGHGAEPDPAASLAPALAGVAQPVVVAVVGTAGDPQGRDRQVRALVDAGAEVHLSNAGATRRAIELLGGTR
>NC_008699.1|WP_011754946.1|1569721_1571140_-|DUF1116-domain-containing-protein
MTTPEAVVNVGADLLADAVADQAVPVTRVDWRPPMDGTAADLATVAADPRRQAANERALAAMLGVTATLVDVLPASEALGLEPGQFLHAGPPIGWDRASGPLRGALMGGAALEGLVADPEDAAALFEAGTSVSLEPCHHRSAVGPMAGVVTPSMWVFVLEDPATGRRSYCSLNEGLGKVLRYGAYSPEVITRLRWMGDVLGPLLQRAVRTVRDSEAGPVDVTGILTQMLQMGDEAHNRNRAGTLMLLRDLSPALVGSIGSAGSDPADVAEALRFIGANDHFFLNLAMPACKLALDAARGIDGSTMVVAMARNGTDFGIQVAGTGDEWFTGPAQLADGLFLGDYGPEDANPDIGDSAITETAGIGGFAMATAPAIVRFVGGSVPDALATTRRMHEITLGENPRWSVPVLEFQGTPTGIDVTMVCRTGILPQINTGMAGKLAGVGQVGAGLVTPPAEIFPKALARLAELACPRS
>NC_008699.1|WP_011754945.1|1568824_1569634_+|ABC-transporter-permease
MSVLVEGASDAWVITRRNLRKILRVPDVLVFTTLSPIMFVLLFAYVFGNAIGSQDTGVDYTEFLVPGIFAQTVVFGATFTGYSLAEDLQKGIIDRFRSLPMSSSSVVLGRTVADIGINIVSLVVMALTGLVVGWRIRSSMVEALAGFLVLLVFAFAISWIMATVALLVRTPEVVNNASFIVIFPLTFIANTFVSISNLPGPLATFANWNPVSAVCQAARELFGNTDPAATVPDAWSMHHPVLYTLVWVVLILLVFVPLSIRQYRRATSR
>NC_008699.1|WP_041546411.1|1567826_1568825_+|daunorubicin-resistance-protein-DrrA-family-ABC-transporter-ATP-binding-protein
MSTGRPTAIRATGLVKRYGAVTALDGLDLEVEEGTVLGLLGPNGAGKTTAVRVLTTLLRPDAGHAEVAGIDVLRHPRELRRRIGVSGQYAAVDEHLTGFENLDMVGRLYHLGAAESRARARELLDQFDLAHAAGRVVKGWSGGMRRRLDLAGALVAKPPVIFLDEPTTGLDPRGRVGMWDVIEELVRGGTTLLLTTQYLEEADRLADRIAVIDRGTVIALGTADELKAQLGGEQVEVRLPSGGDLVAAARAAAGVGVGEPVIDERDRRLTVPVDGGTHDLRELLDRLDRAGVPVAEAGLRRPTLDDVFLALTGHAAEEPAPAGEDADEDGAA
>NC_008699.1|WP_011754943.1|1567375_1567717_+|MGMT-family-protein
MRIDPEEYAERVLQCVESVPRGRVTTYGAIAEVVGELLGGGGPRQVGSVMSAHGGAVAWWRVVHADGSPPTCHDGEAPQAYLEESTPLRPSGRIDLARAFWRPRLEAEPRPRA
>NC_008699.1|WP_011754942.1|1566839_1567379_+|hypothetical-protein
MNPLRGYGEPDDWARSQVALRMLVLAGPVVAVLAAGPAGHAAPWWLVGVVAALAGASAWVPDSPFGVAPFLVVLGWWAAALGDASSAWVLVAAAGLVVAHVAGAVASYGPATMPVDAATAGLWARRGLLVLLTAPVAWVTARLLRDQPEQPGVWVLGVAAACLATVVATAALGTREEDR
>NC_008699.1|WP_011754941.1|1565520_1566843_+|DUF58-domain-containing-protein
MSPLPPGRGGPASWRPTTALGRALVVGGLGVVGALLSGEPAVVVLAAPFVMLAALGVAHRPTREPVLDSRLDHLTLREGVGTTSRLSVAGAEDAEYLVRVTGQPPYVVMRPSGGRVGRLLAGGQVPEVEISPRRWGRRMLGEEKVALYTPWAGYRFGPVGIGGQWTRVLPTTAPYDSRAEAPQPLGLVGAHRSRRTGSGTELAGIRPFQPGDRLRRVNWRVSLRTRDLHVVTTRAEEDTGVLLVLDALADHGASDGVDGAASSLDLGVRAASAIAEHHVRRGDRVALRVVGRGHEQVGYGAGPRHLRRIQDQLATVRIGVAAEPDSGVLQLGVTGGVVVVVLSPMLAEPVATVAATLTRRGVAVLVVDTLPPDPRPDLPGDADPTLAALAWRMRMVERSVVLDRLAALGCPVVAWRGPGTIDDVLRRLARRGRLPRVVGR
>NC_008699.1|WP_011754940.1|1564501_1565524_+|MoxR-family-ATPase
MTDPVSDPVPDPVSDPASERLSVAEAADLAGRVLDEVEKAVVGKRKALVQVLAAVLAKGHVLLEDYPGLGKTLAARSLARALGIDFARAQFTPDLLPADLTGSFIYDQRRGEFEFRRGPLFTGLLLADEINRTPPKTQAALLEAMQERQVTVEGETFPLSAPFHVLATANPIEYEGTFPLPEAQLDRFLLRVSFGYPSPHEEYDVLARRMARRQEEVELDRVTDGAGLLAMQAAVETVAVDESVGRYCVELAVATRHHPDVLTGASPRGSLGLVLTARAFALLRGRDYVVPEDVKAIARPVLAHRITVKPELWMSDASGRRVVDAVLGQVPTPTTLDGRR
>NC_008699.1|WP_011754950.1|1574953_1576417_+|nitrate-reductase
MSMFKWELVDPKPGEAVAPHQRLSWGKTVGLGAQHVVAMFGATFVFPLIMGLNANLAIMMSGIATICFLLIVQGKVPSYLGTSASFVGAAAAIYAYQGGDGPGGPADVTGAILVAGIVLAIVGVIVHYLGADSVNAVLPPVVTGAVVMLIGFNLAPVATLTYMPSDPWVALITMTAVILMAVGLRGFFGRIAVFLGLIFGYLLSVVWDWIFGQSTLPLPGNPEPGPHDRVNWDAVKNADWFGFPVHTKDGLVGNQAFTDGYANVGWHMPSFSIAFILLALPAVIALVAENIGHVKAVAEMTKTDLDPVMGRAIAADGVGTVIASTVGGSPTTTYAENIGVMAATRVYSTAAYFVAAIVAILLGLVPKFGQIVNATPPAVLGGITLVLYGMIGLLGAKIWKENGVDFAKPINLVPVAAGIILAIGNADLKITDDFHLTGIALGTLVVVLGYHLARVVAPKDLDDGTMIAVGHEGVHAEDHAAPHDHHH
>NC_008699.1|WP_011754951.1|1576434_1577277_+|FAD-binding-domain-containing-protein
MKPAPFEYRRPGTIAEAVTALAGGTDSKVLAGGQSLVPLLSMRLAAPALLVDINAIPGLDTIEVEGEDGGVRVGALARHAAVLASPDVHRVQPLVPMALAHVAHATIRNRGTTVGSLVHADAAAEMPAVLALLGGSVEVEGPAGGRTIPADELFVGPLESSLAHDEIALSAYFPALAPGAGVAFDEIARRHGDYALVGAAALVDGDEVRVGYLSVADVPTVVDLSGVAEEELGDAALTHLEPGDDIHATAEYRAQLVRVLTTRVVRSAREHAQQSREGRR
>NC_008699.1|WP_011754952.1|1577273_1577795_+|(2Fe-2S)-binding-protein
MTEELHDVRLSVNGTTYDTRVPARRLLSDALRHDLGLTGTHVGCEHGVCGACTILVDGEPMRSCLMFAVSAVDHELTTVEGLTNEDGSLSPVQQAFSECHGLQCGFCTPGFLTTITAGLRDNPTPTHEEARDMIAGNLCRCTGYQNIVKAVERAAELVELAELVETPAPEAGR
>NC_008699.1|WP_011754953.1|1577799_1580211_+|xanthine-dehydrogenase-family-protein
MTTKLMGQKVQRVEDQRFLRGQGRYVDDVGVSGSTQLLHAAVLRSPHAHARILDIDVEAVLDLEGVHAVWTYDDLAGLAAPMAEPLPLLIPHPALTHGRTQYALARDEVNYAGEAIAFVVADDRYLAEDAVGRIRVSYEPLPPVVGIDAAREARALVHEDVPGNIGARLEQNVGDAPAAIKAAPHTLSLDLTVERSACTPLEGRGTVARWDPDINRLQVWTSTQSSTGVRAAVAVKLGLDLGQVDVITPDVGGGFGVKINHPWPEELLVPLAARALGRTVKFTEDRREHFISSAHERGQVQHIEVGFDDDGRLLGLDVEFWHDHGAYTPYGLIVPIITSTQLLGPYKPHNYRVVFESLYTNTVMVTPYRGAGRPQGCYAMERTMDAIAAYLGKDRADVRAVNFIQPDEFPFDQGLIFQDGRELEYDSGDYPASLEKIKALVGWDEFPAFQREMAAQGRRVGIGLACYVEGTGVGPYEGAHVHIETSGKVKVATGLTTQGQGHATVFAQLVADELGVKFEDVEVVTGDTRRMAYAVGTFASRAAVMSGSAIHLAAKRAKEKVLKIAADALEAAPEDLEIVDGVVSVKGSPGASIDLGTVSVLSNPLRYAFDEASKAATQFSVGDPGKPPVAEDDEPGLEGKDFYSPERATFASGMHAVIVETDPETAEIKILKYAVVHDCGHLINPMIVEGQIHGGVAQGVGGALYERMAYDESGQLLNASFMDFLMPYVTEVPDGIDIDHLETPSPLNPLGIKGAGEAGVIPSAAVFAAAIEDAERVDRPALAITAMPISPSELYTLRQEHPR
>NC_008699.1|WP_011754954.1|1580207_1580858_+|carbon-monoxide-dehydrogenase-subunit-G
MKITGSNVVPYPVEQVWDAILDPRVLVATIPGCERLETRSSTPGSEHAYDMTVTAGVAAIKGTYAGACVLSDLVEHESLVMRLEGAGAPGTIDATVNVYFGEAEPGHTKIDYDADAVVGGMVGGVGQRMLTSVSRRMAGEFFSNVGQAIGAPAPAAAVAAAPGAAGAPGAPAAVGQVFTAPAKAGIASRDDFVKGIAVGAGLVLLGVLAGSLRRRR
>NC_008699.1|WP_011754955.1|1581000_1582407_+|amidase
MSGVTVESTAREQAAAVRAKEISARELLDLHLARIAERNPELNAIVSLDEERAREGAAEADRALAAADRDGTDVGPLHGLPFAFKDTHAVAGWRTTYGSPLYADHVPDADELIVERVRRAGVVVIGKTNVPEFAAGSHTFNRVFGTTLNPVDPSRSAGGSSGGAASALAAGMVPLADGSDMGGSLRNPASFCGVFGLRPSLGRVPEWPLYNQWETTSVGGPMARNVGDLALLLSVLAGPDPRAPQALGDPGATFAPPLAGSLAGLRVAVSVDLGGAFEVDHEVAAVVESSAAAFTAAGAQVTAAHPVLTEADDTFRTLRAWHLQAKLGGLLAAHPDGLKPSLADNIRLGEHLTGADVARAYTQRTALSERMREFFVPGGQGFDLLVLPVSQVPPFPADQEYPATINGRPMQTYLDWMRAAYLITVTGCPAISVPFGHTSDGLPIGLQLVAAHGRDRFLLETAAALEAR
>NC_008699.1|WP_083768105.1|1583391_1583637_-|DUF2630-family-protein
MADPEIQDRIKSLIDEEHRLRASLSAGDISPGEEHDRLHDLEVELDQCWDLLRQRRAKREAGRDPAEAAVRPPGTVENYRQ
>NC_008699.1|WP_011754956.1|1583772_1584438_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MYAVLHTVVPPVAKAIWRPQVVGLENVPRTGPVILASNHLSFADSLVIPIVAPRKVVFLAKSDYFAGGGVKGTLQKAWFEGMGMLPVDRDDTKAALASLDTALDVLGRGEAFGIYPEGTRSRDGRLYRGRTGVAHLALTAGAPVVPVGLTGTERLQPVGAKLPRVVPVTVRFGRAIDVAGRYDGVPPGRARREVTDEIMAAIQELSGQEQAGIYNDRAPDA
>NC_008699.1|WP_140403972.1|1584484_1585900_+|amidohydrolase-family-protein
MRPGVSCGFWLPAAATSNSRAGRPCRRTPVPSAISAVVGVDAARLNRRVPTHQIVVADARLRHPPGGRDGRWQVGIDDGRITALAQDPLTGTDEIDAAGALVTESFVNGHMHLDKVHTLDRIGDAALTAYTSGDMGSAMTSIELASAVKAGYDRSWIEPNARTAVLEAVRYGVRHVLAFADVDPKARLEGVIPLLALREEFRGVVDLQVVAFPQDGLLRDPGAEELVREAVELGADVVGGIPWIEHTDADAREHVQRMCALAATHDRRVAMLVDDAGDAGLRTTEMLAVAMIEHGLVGRGVANHARAVGLYARPSLERLAGLARRAGLGFVSDPHTGPLHLPVRELTAMGVPVALGQDDIEDAYYPFGRHNMGEIAFLAAHALEAVDSAGIDLVYDGVTTTAARVLGVIGHRLEVGGNADLVVHHHPTLREVVGHHAAPAYVLASGRLVASSSATTTFHLDNLDNLEGNQP
>NC_008699.1|WP_011754958.1|1585896_1588017_+|hydantoinase/oxoprolinase-family-protein
MTRSIRIGIDTGGTFTDVVAFDEDSGELVTTKTPSTPSNPADGFLAGIDKVLAVLGASGADIDAVSHGTTVATNQLLEGKVDRLGFITTAGYEAMLEIARQSVPDGYGNSYFWVKPDRIVPRDRVKGVGGRLDFTGAEVRPFDEDAARAAARWFRAQGINTLGVCFLHAYANPEHEERMRAVLAEEHPDAVVSLSSEVLREYREYERAMTTLVDAAVKPRLSAYVSNIKARLAGYVPAGASGGAPRVVPFYVMKSNGGVLSADEVVHQPITTVLSGPAAGALGAALIAKVAGFDKVLTSDGGGTSTDVSVVIDGEPTLTTEGSVGAFPSKIPMIDVVTVGAGGGSIAWLSPEGTLKVGPQSAGADPGPLCYGKGGTEVTITDAHVVLGRIPPHLLGGEIPLDVDAARAGVEQLAAKLGLTPEACATGILEISAWNQANALRQVTVKRGLDVRDFTLTTFGGSGSLLLCRLMDVLGIPTVLVPPNPGNVSAFGLLTVDVKNDYVQTHVTLDDHLDPAAVTGIYDELTARAAEALAKEGFEPAEHQFVRTADLRYFGQAFEVRVPVAAGALDPQAVADAFHAEHKALYGYDFSGDSSQQVEWVNLRVSGIGPIKRPAITRHPVESGVLATDSPDSTVTTPDSTVRAVCFDAAEGYVDTPVLWRPDLAPGTVLDGPAIIEEFGSTVPLHPGFTARIDEYLNIIVTRSQA

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Crispr_ID: NC_008699_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_18

1580880-1580965

Orphan

Consensus_repeat	Method
CGGTTTCCCCGGTTCACCGGGGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_18

>merge|NC_008699|18|1580880-1580965|CRISPRCasFinder
CGGTTTCCCCGGTTCACCGGGGAAGTTGGAACTTCTGGCCCGAAGTTTCGGCCCAACACTTCCGGTTTCCCCGGTTCACCGGGGAA

>NC_008699|18|18|1580880-1580965|CRISPRCasFinder
CGGTTTCCCCGGTTCACCGGGGAA	GTTGGAACTTCTGGCCCGAAGTTTCGGCCCAACACTTC
CGGTTTCCCCGGTTCACCGGGGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011754952.1\|1577273_1577795_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NC_008699.1\|WP_011754947.1\|1571136_1572552_-\|FdrA-family-protein	unknown	unknown	gnl\|CDD\|180395
NC_008699.1\|WP_011754953.1\|1577799_1580211_+\|xanthine-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|376913
NC_008699.1\|WP_011754949.1\|1573277_1574594_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225306
NC_008699.1\|WP_011754954.1\|1580207_1580858_+\|carbon-monoxide-dehydrogenase-subunit-G	unknown	unknown	gnl\|CDD\|176853
NC_008699.1\|WP_011754951.1\|1576434_1577277_+\|FAD-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224238
NC_008699.1\|WP_011754946.1\|1569721_1571140_-\|DUF1116-domain-containing-protein	unknown	unknown	gnl\|CDD\|377673
NC_008699.1\|WP_083768105.1\|1583391_1583637_-\|DUF2630-family-protein	unknown	unknown	gnl\|CDD\|378515
NC_008699.1\|WP_140403972.1\|1584484_1585900_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238618
NC_008699.1\|WP_011754956.1\|1583772_1584438_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NC_008699.1\|WP_011754961.1\|1590867_1591542_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187561
NC_008699.1\|WP_011754948.1\|1572548_1573202_-\|DUF2877-domain-containing-protein	unknown	unknown	gnl\|CDD\|378658
NC_008699.1\|WP_011754945.1\|1568824_1569634_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NC_008699.1\|WP_011754962.1\|1591620_1592316_-\|TIGR00266-family-protein	unknown	unknown	gnl\|CDD\|376704
NC_008699.1\|WP_011754960.1\|1590145_1590841_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011754950.1\|1574953_1576417_+\|nitrate-reductase	unknown	unknown	gnl\|CDD\|132655
NC_008699.1\|WP_041546412.1\|1588093_1590043_+\|hydantoinase-B/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|376810
NC_008699.1\|WP_011754958.1\|1585896_1588017_+\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223
NC_008699.1\|WP_011754955.1\|1581000_1582407_+\|amidase	unknown	unknown	gnl\|CDD\|236028
NC_008699.1\|WP_011754963.1\|1592424_1592826_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|377622

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011754952.1\|1577273_1577795_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	2.59998e-67
NC_008699.1\|WP_011754947.1\|1571136_1572552_-\|FdrA-family-protein	gnl\|CDD\|180395	PRK06091, PRK06091, membrane protein FdrA; Validated.	3.59825e-132
NC_008699.1\|WP_011754953.1\|1577799_1580211_+\|xanthine-dehydrogenase-family-protein	gnl\|CDD\|376913	pfam02738, Ald_Xan_dh_C2, Molybdopterin-binding domain of aldehyde dehydrogenase.	0
NC_008699.1\|WP_011754949.1\|1573277_1574594_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	3.67112e-15
NC_008699.1\|WP_011754954.1\|1580207_1580858_+\|carbon-monoxide-dehydrogenase-subunit-G	gnl\|CDD\|176853	cd05018, CoxG, Carbon monoxide dehydrogenase subunit G (CoxG). CoxG has been shown, in Oligotropha carboxidovorans, to anchor the carbon monoxide (CO) dehydrogenase to the cytoplasmic membrane. The gene encoding CoxG is part of the Cox cluster (coxBCMSLDEFGHIK) located on a low-copy-number, circular, megaplasmid pHCG3. This cluster includes genes encoding subunits of CO dehydrogenase and several accessory components involved in the utilization of CO. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	7.24297e-49
NC_008699.1\|WP_011754951.1\|1576434_1577277_+\|FAD-binding-domain-containing-protein	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	7.80203e-58
NC_008699.1\|WP_011754946.1\|1569721_1571140_-\|DUF1116-domain-containing-protein	gnl\|CDD\|377673	pfam06545, DUF1116, Protein of unknown function (DUF1116). This family contains hypothetical bacterial proteins of unknown function.	6.31904e-120
NC_008699.1\|WP_083768105.1\|1583391_1583637_-\|DUF2630-family-protein	gnl\|CDD\|378515	pfam10944, DUF2630, Protein of unknown function (DUF2630). This bacterial family of proteins have no known function.	2.32602e-33
NC_008699.1\|WP_140403972.1\|1584484_1585900_+\|amidohydrolase-family-protein	gnl\|CDD\|238618	cd01293, Bact_CD, Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi, but not mammalian cells. The bacterial enzymes, but not the fungal enzymes, are related to the adenosine deaminases (ADA). The bacterial enzymes are iron dependent and hexameric.	2.06185e-89
NC_008699.1\|WP_011754956.1\|1583772_1584438_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	1.25807e-52
NC_008699.1\|WP_011754961.1\|1590867_1591542_+\|NAD(P)H-binding-protein	gnl\|CDD\|187561	cd05251, NmrA_like_SDR_a, NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs. NmrA and HSCARG like proteins. NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. HSCARG has been identified as a putative NADP-sensing molecule, and redistributes and restructures in response to NADPH/NADP ratios. Like NmrA, it lacks most of the active site residues of the SDR family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Atypical SDRs are distinct from classical SDRs. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	9.81806e-23
NC_008699.1\|WP_011754948.1\|1572548_1573202_-\|DUF2877-domain-containing-protein	gnl\|CDD\|378658	pfam11392, DUF2877, Protein of unknown function (DUF2877). This bacterial family of proteins are putative carboxylase proteins however this cannot be confirmed.	2.20176e-23
NC_008699.1\|WP_011754945.1\|1568824_1569634_+\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	6.24417e-16
NC_008699.1\|WP_011754962.1\|1591620_1592316_-\|TIGR00266-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	2.18296e-86
NC_008699.1\|WP_011754950.1\|1574953_1576417_+\|nitrate-reductase	gnl\|CDD\|132655	TIGR03616, Putative_pyrimidine_permease_RutG, pyrimidine utilization transport protein G. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the uracil-xanthine permease family defined by TIGR00801. As well as the The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40).	4.51536e-101
NC_008699.1\|WP_041546412.1\|1588093_1590043_+\|hydantoinase-B/oxoprolinase-family-protein	gnl\|CDD\|376810	pfam02538, Hydantoinase_B, Hydantoinase B/oxoprolinase. This family includes N-methylhydaintoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase EC:3.5.2.9 which catalyzes the formation of L-glutamate from 5-oxo-L-proline. These enzymes are part of the oxoprolinase family and are related to pfam01968.	1.43118e-152
NC_008699.1\|WP_011754958.1\|1585896_1588017_+\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	0
NC_008699.1\|WP_011754955.1\|1581000_1582407_+\|amidase	gnl\|CDD\|236028	PRK07486, PRK07486, amidase; Provisional.	4.6706e-155
NC_008699.1\|WP_011754963.1\|1592424_1592826_+\|cupin-domain-containing-protein	gnl\|CDD\|377622	pfam06172, Cupin_5, Cupin superfamily (DUF985). Family of uncharacterized proteins found in bacteria and eukaryotes that belongs to the Cupin superfamily.	1.11033e-52

>NC_008699.1|WP_011754954.1|1580207_1580858_+|carbon-monoxide-dehydrogenase-subunit-G
MKITGSNVVPYPVEQVWDAILDPRVLVATIPGCERLETRSSTPGSEHAYDMTVTAGVAAIKGTYAGACVLSDLVEHESLVMRLEGAGAPGTIDATVNVYFGEAEPGHTKIDYDADAVVGGMVGGVGQRMLTSVSRRMAGEFFSNVGQAIGAPAPAAAVAAAPGAAGAPGAPAAVGQVFTAPAKAGIASRDDFVKGIAVGAGLVLLGVLAGSLRRRR
>NC_008699.1|WP_011754953.1|1577799_1580211_+|xanthine-dehydrogenase-family-protein
MTTKLMGQKVQRVEDQRFLRGQGRYVDDVGVSGSTQLLHAAVLRSPHAHARILDIDVEAVLDLEGVHAVWTYDDLAGLAAPMAEPLPLLIPHPALTHGRTQYALARDEVNYAGEAIAFVVADDRYLAEDAVGRIRVSYEPLPPVVGIDAAREARALVHEDVPGNIGARLEQNVGDAPAAIKAAPHTLSLDLTVERSACTPLEGRGTVARWDPDINRLQVWTSTQSSTGVRAAVAVKLGLDLGQVDVITPDVGGGFGVKINHPWPEELLVPLAARALGRTVKFTEDRREHFISSAHERGQVQHIEVGFDDDGRLLGLDVEFWHDHGAYTPYGLIVPIITSTQLLGPYKPHNYRVVFESLYTNTVMVTPYRGAGRPQGCYAMERTMDAIAAYLGKDRADVRAVNFIQPDEFPFDQGLIFQDGRELEYDSGDYPASLEKIKALVGWDEFPAFQREMAAQGRRVGIGLACYVEGTGVGPYEGAHVHIETSGKVKVATGLTTQGQGHATVFAQLVADELGVKFEDVEVVTGDTRRMAYAVGTFASRAAVMSGSAIHLAAKRAKEKVLKIAADALEAAPEDLEIVDGVVSVKGSPGASIDLGTVSVLSNPLRYAFDEASKAATQFSVGDPGKPPVAEDDEPGLEGKDFYSPERATFASGMHAVIVETDPETAEIKILKYAVVHDCGHLINPMIVEGQIHGGVAQGVGGALYERMAYDESGQLLNASFMDFLMPYVTEVPDGIDIDHLETPSPLNPLGIKGAGEAGVIPSAAVFAAAIEDAERVDRPALAITAMPISPSELYTLRQEHPR
>NC_008699.1|WP_011754952.1|1577273_1577795_+|(2Fe-2S)-binding-protein
MTEELHDVRLSVNGTTYDTRVPARRLLSDALRHDLGLTGTHVGCEHGVCGACTILVDGEPMRSCLMFAVSAVDHELTTVEGLTNEDGSLSPVQQAFSECHGLQCGFCTPGFLTTITAGLRDNPTPTHEEARDMIAGNLCRCTGYQNIVKAVERAAELVELAELVETPAPEAGR
>NC_008699.1|WP_011754951.1|1576434_1577277_+|FAD-binding-domain-containing-protein
MKPAPFEYRRPGTIAEAVTALAGGTDSKVLAGGQSLVPLLSMRLAAPALLVDINAIPGLDTIEVEGEDGGVRVGALARHAAVLASPDVHRVQPLVPMALAHVAHATIRNRGTTVGSLVHADAAAEMPAVLALLGGSVEVEGPAGGRTIPADELFVGPLESSLAHDEIALSAYFPALAPGAGVAFDEIARRHGDYALVGAAALVDGDEVRVGYLSVADVPTVVDLSGVAEEELGDAALTHLEPGDDIHATAEYRAQLVRVLTTRVVRSAREHAQQSREGRR
>NC_008699.1|WP_011754950.1|1574953_1576417_+|nitrate-reductase
MSMFKWELVDPKPGEAVAPHQRLSWGKTVGLGAQHVVAMFGATFVFPLIMGLNANLAIMMSGIATICFLLIVQGKVPSYLGTSASFVGAAAAIYAYQGGDGPGGPADVTGAILVAGIVLAIVGVIVHYLGADSVNAVLPPVVTGAVVMLIGFNLAPVATLTYMPSDPWVALITMTAVILMAVGLRGFFGRIAVFLGLIFGYLLSVVWDWIFGQSTLPLPGNPEPGPHDRVNWDAVKNADWFGFPVHTKDGLVGNQAFTDGYANVGWHMPSFSIAFILLALPAVIALVAENIGHVKAVAEMTKTDLDPVMGRAIAADGVGTVIASTVGGSPTTTYAENIGVMAATRVYSTAAYFVAAIVAILLGLVPKFGQIVNATPPAVLGGITLVLYGMIGLLGAKIWKENGVDFAKPINLVPVAAGIILAIGNADLKITDDFHLTGIALGTLVVVLGYHLARVVAPKDLDDGTMIAVGHEGVHAEDHAAPHDHHH
>NC_008699.1|WP_011754949.1|1573277_1574594_+|helix-turn-helix-domain-containing-protein
MLISGDREELASAALAKVDALHTGLTQIVLEGGNLDGIAAEVARVLEVGVAFTSTDGRERASALPEDLRSALDSHDLVDPTGRLRVERMAGDGAPVETGEARSLRVAAGGVDLARLVCLRPDEPLSSDDVHALERAAAVAALLITREEAVTAVENKYQGDFLRDLLMRRGGLANDQAYVTEHAATFGWDLARPVVVVSAEIDPVPGEEPVGGVQRRQWQERFSAAWRQVSNGLGTGIPCVDFSSEVVTLLPLAGYGPEDDPGDRREDEPVAGHDVVRRAVTAVAGDKGGGRRSFSVGVSRVARTLDELPGAYAQARRAVEVGRRVSGWGSTTFFDQLGLHRLIALIPPEENGELRSFVRDVLGPLAEPTSEAADLRETLQVLLDTNFNVAEAARLQFFHYNTMRYRVSKLERLLGPLSTDPHLRLDVAVALRVLELAG
>NC_008699.1|WP_011754948.1|1572548_1573202_-|DUF2877-domain-containing-protein
MIPVSAPARVRARLHAAPDGPLPVVHRGRDAIYLDLAGSCVGVVGTRATAVPCALRTALDALDAGSARVTGGVLHLDDEPLVIGRIVDVTVPRLTAATTSGPAPLPGDVREMVGRGDGLTPYDDDVLCGWLAVHRGLGVPTPDADAAIRACVDRTTLLSATLLDCAMHGEVIPEFAAWVATPDDPDRTATLAAVGHTSGRGMLQGARFVLDHLRGAA
>NC_008699.1|WP_011754947.1|1571136_1572552_-|FdrA-family-protein
MTTPSPTHVELRPGAYADSVTLLQVSRVVQGLPGVLAAQVAMATPLNVEVLTGMGFEVPAQAGPNDLVVALRLEAADALPAALAGVDQALRDANRRDEGAATIAPPRTTASALRRTPDAVALVSVPGAHAFVEAMDAVEAGRDVMVFSDNVPLEQELALKRAAAERGVLVMGPDCGTAVVDGVGLGFANVVEPGPVGIVAASGTGCQQLLALLDHAGVGVTSALGVGGRDLSAEVRGLATREALRRLDEDPGVELIVLISKPPAADVTAEIEAYAAALATPVELALLGPGRPDLTAAAEAVLRRLGREVPAWPVDPPDVSPRVNPGALRGLFVGGTLASEAALVAGELLGEADGHTFVDFGDDEYTTGRAHPMIDPSIRLEHLARAAADPTTGVLLLDVVLGHGAEPDPAASLAPALAGVAQPVVVAVVGTAGDPQGRDRQVRALVDAGAEVHLSNAGATRRAIELLGGTR
>NC_008699.1|WP_011754946.1|1569721_1571140_-|DUF1116-domain-containing-protein
MTTPEAVVNVGADLLADAVADQAVPVTRVDWRPPMDGTAADLATVAADPRRQAANERALAAMLGVTATLVDVLPASEALGLEPGQFLHAGPPIGWDRASGPLRGALMGGAALEGLVADPEDAAALFEAGTSVSLEPCHHRSAVGPMAGVVTPSMWVFVLEDPATGRRSYCSLNEGLGKVLRYGAYSPEVITRLRWMGDVLGPLLQRAVRTVRDSEAGPVDVTGILTQMLQMGDEAHNRNRAGTLMLLRDLSPALVGSIGSAGSDPADVAEALRFIGANDHFFLNLAMPACKLALDAARGIDGSTMVVAMARNGTDFGIQVAGTGDEWFTGPAQLADGLFLGDYGPEDANPDIGDSAITETAGIGGFAMATAPAIVRFVGGSVPDALATTRRMHEITLGENPRWSVPVLEFQGTPTGIDVTMVCRTGILPQINTGMAGKLAGVGQVGAGLVTPPAEIFPKALARLAELACPRS
>NC_008699.1|WP_011754945.1|1568824_1569634_+|ABC-transporter-permease
MSVLVEGASDAWVITRRNLRKILRVPDVLVFTTLSPIMFVLLFAYVFGNAIGSQDTGVDYTEFLVPGIFAQTVVFGATFTGYSLAEDLQKGIIDRFRSLPMSSSSVVLGRTVADIGINIVSLVVMALTGLVVGWRIRSSMVEALAGFLVLLVFAFAISWIMATVALLVRTPEVVNNASFIVIFPLTFIANTFVSISNLPGPLATFANWNPVSAVCQAARELFGNTDPAATVPDAWSMHHPVLYTLVWVVLILLVFVPLSIRQYRRATSR
>NC_008699.1|WP_011754955.1|1581000_1582407_+|amidase
MSGVTVESTAREQAAAVRAKEISARELLDLHLARIAERNPELNAIVSLDEERAREGAAEADRALAAADRDGTDVGPLHGLPFAFKDTHAVAGWRTTYGSPLYADHVPDADELIVERVRRAGVVVIGKTNVPEFAAGSHTFNRVFGTTLNPVDPSRSAGGSSGGAASALAAGMVPLADGSDMGGSLRNPASFCGVFGLRPSLGRVPEWPLYNQWETTSVGGPMARNVGDLALLLSVLAGPDPRAPQALGDPGATFAPPLAGSLAGLRVAVSVDLGGAFEVDHEVAAVVESSAAAFTAAGAQVTAAHPVLTEADDTFRTLRAWHLQAKLGGLLAAHPDGLKPSLADNIRLGEHLTGADVARAYTQRTALSERMREFFVPGGQGFDLLVLPVSQVPPFPADQEYPATINGRPMQTYLDWMRAAYLITVTGCPAISVPFGHTSDGLPIGLQLVAAHGRDRFLLETAAALEAR
>NC_008699.1|WP_083768105.1|1583391_1583637_-|DUF2630-family-protein
MADPEIQDRIKSLIDEEHRLRASLSAGDISPGEEHDRLHDLEVELDQCWDLLRQRRAKREAGRDPAEAAVRPPGTVENYRQ
>NC_008699.1|WP_011754956.1|1583772_1584438_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MYAVLHTVVPPVAKAIWRPQVVGLENVPRTGPVILASNHLSFADSLVIPIVAPRKVVFLAKSDYFAGGGVKGTLQKAWFEGMGMLPVDRDDTKAALASLDTALDVLGRGEAFGIYPEGTRSRDGRLYRGRTGVAHLALTAGAPVVPVGLTGTERLQPVGAKLPRVVPVTVRFGRAIDVAGRYDGVPPGRARREVTDEIMAAIQELSGQEQAGIYNDRAPDA
>NC_008699.1|WP_140403972.1|1584484_1585900_+|amidohydrolase-family-protein
MRPGVSCGFWLPAAATSNSRAGRPCRRTPVPSAISAVVGVDAARLNRRVPTHQIVVADARLRHPPGGRDGRWQVGIDDGRITALAQDPLTGTDEIDAAGALVTESFVNGHMHLDKVHTLDRIGDAALTAYTSGDMGSAMTSIELASAVKAGYDRSWIEPNARTAVLEAVRYGVRHVLAFADVDPKARLEGVIPLLALREEFRGVVDLQVVAFPQDGLLRDPGAEELVREAVELGADVVGGIPWIEHTDADAREHVQRMCALAATHDRRVAMLVDDAGDAGLRTTEMLAVAMIEHGLVGRGVANHARAVGLYARPSLERLAGLARRAGLGFVSDPHTGPLHLPVRELTAMGVPVALGQDDIEDAYYPFGRHNMGEIAFLAAHALEAVDSAGIDLVYDGVTTTAARVLGVIGHRLEVGGNADLVVHHHPTLREVVGHHAAPAYVLASGRLVASSSATTTFHLDNLDNLEGNQP
>NC_008699.1|WP_011754958.1|1585896_1588017_+|hydantoinase/oxoprolinase-family-protein
MTRSIRIGIDTGGTFTDVVAFDEDSGELVTTKTPSTPSNPADGFLAGIDKVLAVLGASGADIDAVSHGTTVATNQLLEGKVDRLGFITTAGYEAMLEIARQSVPDGYGNSYFWVKPDRIVPRDRVKGVGGRLDFTGAEVRPFDEDAARAAARWFRAQGINTLGVCFLHAYANPEHEERMRAVLAEEHPDAVVSLSSEVLREYREYERAMTTLVDAAVKPRLSAYVSNIKARLAGYVPAGASGGAPRVVPFYVMKSNGGVLSADEVVHQPITTVLSGPAAGALGAALIAKVAGFDKVLTSDGGGTSTDVSVVIDGEPTLTTEGSVGAFPSKIPMIDVVTVGAGGGSIAWLSPEGTLKVGPQSAGADPGPLCYGKGGTEVTITDAHVVLGRIPPHLLGGEIPLDVDAARAGVEQLAAKLGLTPEACATGILEISAWNQANALRQVTVKRGLDVRDFTLTTFGGSGSLLLCRLMDVLGIPTVLVPPNPGNVSAFGLLTVDVKNDYVQTHVTLDDHLDPAAVTGIYDELTARAAEALAKEGFEPAEHQFVRTADLRYFGQAFEVRVPVAAGALDPQAVADAFHAEHKALYGYDFSGDSSQQVEWVNLRVSGIGPIKRPAITRHPVESGVLATDSPDSTVTTPDSTVRAVCFDAAEGYVDTPVLWRPDLAPGTVLDGPAIIEEFGSTVPLHPGFTARIDEYLNIIVTRSQA
>NC_008699.1|WP_041546412.1|1588093_1590043_+|hydantoinase-B/oxoprolinase-family-protein
MSRRAPTQFPFGHLTADAGASADPVLVEIVQGSLASVEMEVETAIGRTSRSPMIRDAHDFRAGIHDRLLRKLTGRSYSALVHPVARDFPIEEMREGDVFFHNDVYRSEGGIGHLPDLCVTVPVFAKDAGASGGSTGGGAPRVVAFVQAFGHHDDIGGAVPGSMPSHATSVFEEGLMVPPIRLWDAGVPNRSALAIMTRNSRMPESLAADLDAECSACLMGARRLGELFDRYGLDAVESCFDAIINRTTETYRREILGKIPVGSWVWEDYAEHDGVDEPQLHTQRITLTRTPADDPEGERLILDFDGTSPQAKGPINHCGDYSDGVFLKKWLAPILRNLADTPERMAELDVNEGIVPLIEMRFPEPGTLLTPVFPAPTNARTFVILRLLGVLAGVVAKAVDGRMPADQETIRYTGVYGEDLEGRPYLMREVLGGGSGGRYYADGEDTIHVVPDSRNLPTEFTEARFPFRVESLSLAVDSGGAGQYRGGLGYEKHLRMLKDGHFMSIADRSILACWGVKGGRAGQPFQVTIDPGGPNEREVDALADAEPVAAGEVIRIRTTGGGGWGDPLRRDPALVVRDVVWRKVSPEAALGDYGVVLTGSLDDDSLGYDEAATAAERAARPAASEAFFDRGPGYATLAAGAPYAAVDLV
>NC_008699.1|WP_011754960.1|1590145_1590841_+|hypothetical-protein
MGTTDVLSRSLDHTHSRLAERLEAARAMAAPPGEPRRDRQRIDAFLGETSKHLHAVDAVLVPEARRALGDGGPRVHDYVHAVKELEVVLAHVKAHEYGSVYESSFAWPAVWADVDEALAEQARREHDLGERLTDALGDDDLGRLAERLRSAEQAAPSRPHPYTPHTGLLGLVARRVMHVADRFWDAVEGRMVPEPERAPKPPPGRVAQYFLADPHFDPRFEQERRAGRRSR
>NC_008699.1|WP_011754961.1|1590867_1591542_+|NAD(P)H-binding-protein
MTRIALLGGHGKTGRAVAAALAARGAEPVALGRADWPDLTGAVAGCAAAYVVAPNLHPDEPGYVAAALDALHAAGVPRIGYHSVASPYCPELPHHLGKAVSEDLVRRSGLAWTILQPGAYLQNLDLSGPVRVPYDVHAVFGFADLADVGAAAATVLLEDGHAGATYELATRVTTVAELAAEAGVTAERVEDPGTHPWLSAMFAYYDAHGLPVGTLPLRALLGRV
>NC_008699.1|WP_011754962.1|1591620_1592316_-|TIGR00266-family-protein
MQSEVMYSPAYATAKLTLAAGEAVRAESGAMLAMSPGIAMETSTQGGVLKGLKRSVLGGESFFMNTFTAQVDGAELYVAPALPGDVVAWPLNGVLYVQSGSFLAASSNIQVDTKWGGGKTFFSSEGLFMLRIEGQGELVLSSYGAIHAIDLQAGQTYTVDTGHMVAWTDGVQYNVRKVGNWKSTFFSGEGLVCDLTGPGRIYLQTRSQDAFLGWLVPKLPTQKSGGDSLFS
>NC_008699.1|WP_011754963.1|1592424_1592826_+|cupin-domain-containing-protein
MRPPLAETLDLQPHPEGGWYRQTWSAPETVTLPDGRVRPTATLIYFLLPAGESSAWHRVASDELWLAHRGAVALELGGVGPAPVLESTAVVDVERPQALVPAGTWQRTVPAEADALVSCLVSPGFDFDDFELA

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Crispr_ID: NC_008699_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_19

1892423-1892507

Orphan

Consensus_repeat	Method
TCCCCGGTGAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_19

>merge|NC_008699|19|1892423-1892507|CRISPRCasFinder
TCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAACATCCCCGGTGAACCGGGGAAACCG

>NC_008699|19|19|1892423-1892507|CRISPRCasFinder
TCCCCGGTGAACCGGGGAAACCG	GAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAACA
TCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_140404170.1\|1895031_1896849_+\|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224170
NC_008699.1\|WP_011755245.1\|1898527_1898767_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011755233.1\|1883214_1883397_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011755247.1\|1899775_1901683_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173812
NC_008699.1\|WP_086000405.1\|1884074_1885151_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|379588
NC_008699.1\|WP_041546458.1\|1892143_1892395_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011755250.1\|1903375_1903918_-\|CGNR-zinc-finger-domain-containing-protein	unknown	unknown	gnl\|CDD\|378696
NC_008699.1\|WP_011755237.1\|1886981_1887560_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_083768289.1\|1892571_1893246_-\|endonuclease-NucS	unknown	unknown	gnl\|CDD\|235114
NC_008699.1\|WP_011755242.1\|1893312_1894860_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NC_008699.1\|WP_011755244.1\|1896988_1898470_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340874
NC_008699.1\|WP_140404169.1\|1889511_1890567_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_008699.1\|WP_011755240.1\|1890651_1891584_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|334462
NC_008699.1\|WP_140404172.1\|1902524_1903328_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|182637
NC_008699.1\|WP_011755234.1\|1883444_1883969_+\|ferritin	unknown	unknown	gnl\|CDD\|153113
NC_008699.1\|WP_083768287.1\|1891558_1892260_-\|DUF952-domain-containing-protein	unknown	unknown	gnl\|CDD\|377607
NC_008699.1\|WP_049774301.1\|1887549_1889370_-\|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379079
NC_008699.1\|WP_049774302.1\|1901685_1902531_+\|endo-alpha-1,4-polygalactosaminidase	unknown	unknown	gnl\|CDD\|377061
NC_008699.1\|WP_041547354.1\|1885234_1886959_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378217
NC_008699.1\|WP_011755246.1\|1898814_1899582_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_140404170.1\|1895031_1896849_+\|NAD(P)-binding-domain-containing-protein	gnl\|CDD\|224170	COG1250, FadB, 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism].	1.48087e-113
NC_008699.1\|WP_011755247.1\|1899775_1901683_-\|S8-family-serine-peptidase	gnl\|CDD\|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	5.0266e-46
NC_008699.1\|WP_086000405.1\|1884074_1885151_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|379588	pfam14378, PAP2_3, PAP2 superfamily.	2.48909e-25
NC_008699.1\|WP_011755234.1\|1883444_1883969_+\|ferritin	gnl\|CDD\|153113	cd01055, Nonheme_Ferritin, nonheme-containing ferritins. Nonheme Ferritin domain, found in archaea and bacteria, is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The ferritin protein shell is composed of 24 protein subunits arranged in 432 symmetry. Each protein subunit, a four-helix bundle with a fifth short terminal helix, contains a dinuclear ferroxidase center (H type). Unique to this group of proteins is a third metal site in the ferroxidase center. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite.	8.69373e-55
NC_008699.1\|WP_011755250.1\|1903375_1903918_-\|CGNR-zinc-finger-domain-containing-protein	gnl\|CDD\|378696	pfam11706, zf-CGNR, CGNR zinc finger. This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	9.26522e-15
NC_008699.1\|WP_049774302.1\|1901685_1902531_+\|endo-alpha-1,4-polygalactosaminidase	gnl\|CDD\|377061	pfam03537, Glyco_hydro_114, Glycoside-hydrolase family GH114. This family is recognized as a glycosyl-hydrolase family, number 114. It is endo-alpha-1,4-polygalactosaminidase, a rare enzyme. It is proposed to be TIM-barrel, the most common structure amongst the catalytic domains of glycosyl-hydrolases.	3.07709e-49
NC_008699.1\|WP_083768289.1\|1892571_1893246_-\|endonuclease-NucS	gnl\|CDD\|235114	PRK03298, PRK03298, endonuclease NucS.	9.27611e-169
NC_008699.1\|WP_011755244.1\|1896988_1898470_+\|MFS-transporter	gnl\|CDD\|340874	cd17316, MFS_SV2_like, Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily. This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.96421e-38
NC_008699.1\|WP_140404169.1\|1889511_1890567_-\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.51909e-07
NC_008699.1\|WP_011755240.1\|1890651_1891584_+\|FAD-binding-oxidoreductase	gnl\|CDD\|334462	pfam01266, DAO, FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.	2.27282e-26
NC_008699.1\|WP_140404172.1\|1902524_1903328_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|182637	PRK10673, PRK10673, esterase.	1.89023e-45
NC_008699.1\|WP_011755242.1\|1893312_1894860_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	2.86446e-40
NC_008699.1\|WP_083768287.1\|1891558_1892260_-\|DUF952-domain-containing-protein	gnl\|CDD\|377607	pfam06108, DUF952, Protein of unknown function (DUF952). This family consists of several hypothetical bacterial and plant proteins of unknown function.	7.78099e-23
NC_008699.1\|WP_049774301.1\|1887549_1889370_-\|right-handed-parallel-beta-helix-repeat-containing-protein	gnl\|CDD\|379079	pfam13229, Beta_helix, Right handed beta helix region. This region contains a parallel beta helix region that shares some similarity with Pectate lyases.	1.23773e-10
NC_008699.1\|WP_041547354.1\|1885234_1886959_+\|hypothetical-protein	gnl\|CDD\|378217	pfam09594, GT87, Glycosyltransferase family 87. The enzymes in this family are glycosyltransferases. PimE is involved in phosphatidylinositol mannoside (PIM) synthesis, a major class of glycolipids in all mycobacteria. PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of PIM. The family also includes alpha(1-->3) arabinofuranosyltransferase, invloved in the synthesis of of mycobacterial arabinogalactan.	0.00864267

>NC_008699.1|WP_041546458.1|1892143_1892395_+|hypothetical-protein
MHVTTLVRPTPRPQFAVEPVAGAVPAERRDAGRQGHQGHRGNPGHQEPIVVHVPMPRGPSDRSSAIRDAYRLERDRPAVDLYL
>NC_008699.1|WP_083768287.1|1891558_1892260_-|DUF952-domain-containing-protein
MALVALATGVAALRRHGTRDRLDRELRPRRGTDQGRDVHTRSTRPGRPGHAPLRRSPSRRISGGTHRAGWARWRPCARTTSTPRSPSGTTTRTTRCSRPRCSGRPSTSWPTRRETGPAGRCDDERVRIFHVATLADWAGAHRTGEYTTSTRGVSLAQQGFIHASRADQWERVLAAFYADVEEPLVLLEIDTDLLGVPVAEEPPAPDVAETFPHVYGAIRVPAVVAVTRLEPPR
>NC_008699.1|WP_011755240.1|1890651_1891584_+|FAD-binding-oxidoreductase
MTDRVIVVGAGVIGLTCAVRLLQAGHRVDVVARDLPLETTSAVAGAFWYPYRALPQDRVAAWSATSYAVFDALADTDPESGVRMVAGTEVFMAPEPDPWWGAAVPGLTRTRDVPPGWVDGWTFTTPVVDTGVYLAWLAGRVEQLGGTITRLNLSALPSGPGLVVNCAGLGARLLGADRTVVPVRGQVVVVEQTGIDRWWLDRSGPTYVVPREHDVVVGGTDVEGEWSRTPSPATAEAILERATRLVPGLRGARVLRHRVGLRPVRPAVRLDRVGDVVHCYGHGGAGVTLSWGAADEVVALAAVSAAAPGG
>NC_008699.1|WP_140404169.1|1889511_1890567_-|alpha/beta-hydrolase
MRLTLLGVLTALLGALLAAPPPPAAAAGAATAAGARATVVAREVVFELENTNATSVLCVPDNQSYEVRGRLVGPRPAVLGHSGPIRINVLVHDLAAGSWFWSLPGHPAYDYARQLARRGETSLVLDRLGYGASPLANGDATCLGAQADMLHQVVQHVRSGRYTFAEPDGDTTPAAAHVVTHGHSVGAAIAQIEAATFDDVDGLVLMSWTDRGATSLATRTAARQSAACLSGPDYAPLTRTGADYRKLMFASAPSGVQRTAARLRVDDPCGDVSSLSPMLVASNLAATQVDAPVLLLYGAEDALNRPAAREQQAAAYPTPVTTRTFAGAGSALPLERSADKVRAAVLRWLRS
>NC_008699.1|WP_049774301.1|1887549_1889370_-|right-handed-parallel-beta-helix-repeat-containing-protein
MAVLLVAAATVLTMLAGAPPAGAHEERPAQFPDGTGHRPSFLGFDNPRQRVVCGSDSGRLIAALPEGAVKDRNERLLDSCRYRSIQDAIDSVRKRQTSVYVLPGTYHEAKWARAERSDYCSHLQTSSTSPLPFSEYIGSLSSPDPGAEQAAADSGESNPIALSYADQRRCAHNLNLIAVFGDRTPGNDSIRCDSRFCGLQLVGTGQTPADVVVDNRFAKLNAIRADRAGGFYLSNMTFQQAEFNAIYVLETDGFVIDRVVARGNDEYGVLAFASDHGLIEDSEAYYNGDSGIYPGSGSDLNADNTEFEATRYAIEIRGNNSHDNTLGYSGTAGNSIWAHDNDFHDNATGIATDSLFPGHPGLPQDHARWNRNRIYSNNSNWYTEFVDTGVCDKPMEQRGYMDGTVCPVVPTPVGTGVLIAGGNYDSTDHNWIYDNWRYGTMQFWVPAPLRDDYDPSHLYDTSNHNHTFENQMGIDPQGHEQPNGMDHWWDDQGVGNCWEDNHYGSAGQTDNFTVPPPSCADGGSVFLPGATVKDAGFLSCSQYDRSDPTWKHPPACEWFDSPSKPARAVAAPGRPASGTVLVAPIAMTAGALALVLGLRRRWSRAD
>NC_008699.1|WP_011755237.1|1886981_1887560_-|hypothetical-protein
MRTRAGRRIGLVLVTLLGLLAAGGFALARSAPSLSAGGPTSVAGTEATGVFEIADRTVRQVRYDDGGTLRYTFELTNDDRFPVTVHGLAADQPPSRLFTYSGLADAAGRSTLRLSPGESVPVTLSLLMGGCETLSARAGAFVTAVVLRIERAGMLTGLPADNVTVTLPEELHTGSPREAFCPNSTATSRPPG
>NC_008699.1|WP_041547354.1|1885234_1886959_+|hypothetical-protein
MRRWSRSPVAVAVVVSATLQILWWRIVATGGGDLAAQDAWAEFARLHPGSAYNLSWYGGMHPVSYSVLSPYLMAAVGVRPTLVVAGTLSAGLLTWALVGRHGRTDARALAVGGYAALALVGNAVSGRVTFAVGTVFALVAICLLLGWPYQRSPVLTLRPARAIAVAVASGLATAASPVAGLFLGLVAATLWLARQRWAAYALGVTPVVVVALSALLFPFSGTQPMPWYSTILPVLVGAAVTVTAPASWRAVRLAAALYAPAVLLVWLVPSPIGTNISRLGLLFGGVLMVGAAAGGWRTSALARRRGPRAARGLLVVAVLTASIWQVATAARDVVNASGQTSWGPDVAPILTELQHRRADRGRVEVVPTRSHREAAVFAPHVPLARGWNRQADAVRNPLFYRDQPLTKVAYRRWLHRWAVQYVVLSSAEPDGAAVAETELITSGLPYLSPVWSDENWTLYAVRRPTPLVSPPAKVVSFGAAHLTVYTPRSGDVVIRVADSPWLSLVEVDPLPPASRSSVASWFAAPACLSGLETEDQANAEAHPHRPDWLVLHAPRAGTYRISAPYKLPRGSSCP
>NC_008699.1|WP_086000405.1|1884074_1885151_+|phosphatase-PAP2-family-protein
MKAGGRVGAGISGREALRLTAWVWALTAVFASVALLRSEHLGIPFRDPGGAMFRGRLGTAFTLLLVFALADALRRAVRLRPLGWSWSDVGRHLRERWTPQRVLLVCSGLLAYHVVYISYRNLKSWDAFNTPLDQELLAIERWFLLGHSPAVLLHGLLGEGQAAVVLAVVYRSFTYLVPLSVVGTLALLPRVREAYVMLCSALWVWILGVGSYYLVPSLGPFASAPEEFAGLRPTAISATQVKYLAERAHFLADPHAGDAFVSISAFASLHVGFTCTVLLVARYYRWRRTTLALATFLSVTMVATVYFGWHFVVDDIAGVVLALAAFTLGRLMVYPVRNGDRSVADGSHAGEDDVVAST
>NC_008699.1|WP_011755234.1|1883444_1883969_+|ferritin
MAAPRFVDQLNAQIGNELAAHNQYLACAVYYDALTMPRMAAFFYAQAVEERAHAAMMIQYLLDTDAEVVIPAVEAPVNAFADVVAPVALALEQERRVTEQVNGLLRIAREEGDFASEQFLQWFIKEQVEEVATMSDLLAVTTRNRDDIEDIEEYVAREQSGAEVDSTAPRQAGA
>NC_008699.1|WP_011755233.1|1883214_1883397_+|hypothetical-protein
MPKARKLPKTECCASKTKCARCPLRMLKEGTLPAGYTVKKRKLVRVDGTKVTKKKLAKAA
>NC_008699.1|WP_083768289.1|1892571_1893246_-|endonuclease-NucS
MRLVVARCQVDYAGRLTAHLPMATRVLMIKADGSVLVHSDGGSYKPLNWMSPPCILREGTTDDGRVEWTVISKNDDTLRILIEEVLHESIHELGVDPGLQKDGVEKHLQEMLAEHPATLSPGLTLVRREYPTAIGPVDLMCKDAEGRNVAVEIKRRGDIDGVEQLTRYLELLNRDPLLAPVRGIFAAQEIKPQARVLATDRGIACAVVDYDALRGLDDPTHRLF
>NC_008699.1|WP_011755242.1|1893312_1894860_-|methyl-accepting-chemotaxis-protein
MPRNGSAAVPLRTLLGVALGLQLLAAVVVRGDRAALALLLVTSVLTAAATALLHRRVLAPLGRASAYVEALAAGDLTGSPGAGADVPLTGALAAVGERTRTAMRDVADSVGSLNGTAESVAATTEAMGQTFAETSTRAAEVSSAAGVVSSNVAAVSTGAREMSDSVTEIARNVTDAVAVAEEAVSMAAEAAAVMAELDSASERIGNVVRLITAIAGQTNLLALNATIEAARAGEAGKGFAVVASEVKTLAQETARATEDITEQVGALQGGSRAAVASLERTQEVISRFADYQATISSAIEEQAATTAEMSRRLLEAADGSQQIAETVRSVATSTAQAMEQLTHTRRAAGELSGLSSDLGAVTGRFRLPEPVVVVHDIGANGGVALEVEGVVSVTHDPKLQAVIVRWLRYQDQAVKPALGMQLELIRKHSLRTVVVDSREAVGAYSAEMNHWIGVEFVPLLERTTMKAFVTVVPRSAVADLANKGWQEGQDGLGFQMVEVASMTEAEEIARRACRL
>NC_008699.1|WP_140404170.1|1895031_1896849_+|NAD(P)-binding-domain-containing-protein
MTSTSPETAAPGAGREFRTIGVIGLGTMGAGIAEVFARAGHAVVGVEKDDESLARGRQYLEHSTSRAVKREKMTEADQAELLGRITFTTSLKDLAEADFVVEAVVESLETKKAIFRDLDEIVSPETILATNTSSLSVTEISTANGSPGRVVGVHFFNPAPVQALVEIVRTVVTEQSVLDETTALVTSLGKAPVVCGDKAGFIANTLLFGYLNHAVAMYEGHYASREDIDAAMRYGCGYPMGPLALLDLIGLDTAYEILETMYHQGRDRLHAPRPILKQMVTAGMLGRKTGRGFYSYEAADSPVVVADELTPSVDQKPQLRHDIKLVGVVGTGTMATGIVEVFAKSGYDVLYVGRSADKVAGVRAAIEKSLDKAIQRGKLEESAKAEVLGRLTGSTSLDDLAPVDIVVEAIAEDLAIKSTLFANLDEICRPGAILATTTSSLPVIECAQATARPHDVIGIHFFNPAPVMKLVEVVSTVVTSDEVTETTRALCDRVGKVAVSCGDRAGFIVNALLFPYLNDAVKMLEAHYATADDIDLAMKQGCALPMGPFELLDVVGNDVSLAIQRELYLEFREPGFAPAPLLEHLVTAGYLGRKTKRGFRDYSAR
>NC_008699.1|WP_011755244.1|1896988_1898470_+|MFS-transporter
MAVETGRITTDIPARLDRLPWARWHWLVVIGLGTVWILDGLEVTIVGSMSDALKPDGTGLGMNNFDIGLAGSMYVAGACLGAPFFGQLTDRLGRKKLFIVTLAVYTVATVLTAFSMNPMWYFACRFLTGCGIGGEYAAINSAIDELIPAKYRGRVDIAINGSFWVGAAGGALLTIPLLDPTMIDQSWGWRLAFGLGAILAVGILVVRRNVPESPRWLFIHGREDEAEQIVRDIERTVSEESHHQLHDVHDTITVRQRTSIGIGLIARTVFTLYPKRTILCFSLFVGQAFLYNAFFFTYGDTLTTFLGVEQTGYYIAVFAASNFAGALLLSPLFDTLGRVKMITATYIGSGVLLAVTGFYLGSFDATTLTLMGAIIFFMASAGASAAYLTASEVFPMETRALCIAFFYAIGTAAGGISGPLFFGWLIEQASADKDITQIAVGYFLGAALMIIGGIVEAFLGVKAEGKSLESIAQPLTAEDTDTGSTGSTQPQHA
>NC_008699.1|WP_011755245.1|1898527_1898767_+|hypothetical-protein
MPMPPPKPSTEGKRDRQVFHEMGQIVRALEVEGPQPPEELARMVGASYWERDRFDRALAYAVADGLVYRTAEGALAAAG
>NC_008699.1|WP_011755246.1|1898814_1899582_+|hypothetical-protein
MDGLVILLLLAAIVAAVVLARRSSKARERERQRAELEPVKKLAFEDITALGEELQALDLDLAGHELGAGENADYQRALDAYESAKTAGDAMSRPDDVRHVTQILEDGRYAIACVRARVAGDPLPTRRPPCFFDPRHGLSVTEVPWTPPGGATRDVPACALDAERVAAGADPDARMVMVGAQRVPYWQGGRAYQPYASGYFGAFTPMDWMFAGLLFGGFGGFDALGEGIGALGEGIGDGIGSIGDGIGDLFDGFDF
>NC_008699.1|WP_011755247.1|1899775_1901683_-|S8-family-serine-peptidase
MPSSRTRLLALTSALAAVLSLTGVASAAAPAAPAAATVGSDLQGAHRGLDRLLADGTPNHRAIVTFAAVPTSTQIGALQALGLVVQPMSHLPLALVEGPVPAMVQAVTAGIGLDVYPDERLQLLDTPSTNAMSSSPAAAQALRTRGFTGKGVTVGVVDSGCDATHSDLADHVVHNVSLLSPEYANAGTDPAIVVPVDQGPVSNTDLGSGHGTHVAGIIAADSSSAEDGSRYGVAPDADLACFAIGAVLFTTAVVTAYDYMLDQPDLLGIDVVNNSWGNSYRQFDPADPVAVATKAVADRGVTVVFAAGNSGSGDVPMSLNPFSQSPWVISVAAGTLDRHRGDFSSNGLVHDNSQPTAIGTEGHTTYTGDRIGLVHPDLTAPGVDIGSTCDSAGTLIGPCGPDENASASGTSMASPHIAGAAAVLLQAQPRLSPEQVRLALQATATPVQATGGPAALPFWEVGYGYANLDRAVQLVRSDGWQGRLRAAAHRADRRVLAADGTAVVRSDFFVHEAPPATAGGSDSASYDVPVSARTRGLAVSLAFPSGGSVGASLFSYTVQVLDPSGKVIATTTSDPVAGSGTALATVRLPQGAEAGTYTFEVTGDYAASDPDTVDSDSLLGRFVTLHVAQLRSSRR
>NC_008699.1|WP_049774302.1|1901685_1902531_+|endo-alpha-1,4-polygalactosaminidase
MIRSREVPGQRRNRAAGYVVARLLVALLLVDLLVLALVAVIPATASADPPPVTPLPTGTDVDYQLGGAAEMPDHVGIVVRDRTDSPADGRYNVCYVNGFQTQPDQRRFWKRHWRLVLKDGGEPVADEAWGEWLLDVRTEAKRADLARVVGRWVRGCAADGFDAVEYDNLDSFTRSHRLVARRQALAYARLLVRAGHRAGLAVGQKNLAGYDGTAIGYDFAVAEECGRYRECASYVRHYGDRVLAIEYRRANFRWTCAHVGDRLAVVLRDRDLTPTGVHEWC
>NC_008699.1|WP_140404172.1|1902524_1903328_+|alpha/beta-fold-hydrolase
MLNESGPHQGLHVTSLGERGPLVAFCHGLFGQGKNWTTVAKAVAEDHRVLLVDMPHHGRSEWVDHFDYVDVADRVAGLFEAEDPVALVGHSMGGKAAMVLALRHPELVERLCVVDVSPVDYEERGEFAGYIDAMLALDLATLEHRRDADAALADAVPSPTVRSFLLQNLHHHAGRWTWRPNLAVLGRDLEALGGWPEDALAGRPPYQRPTLWIAGQRSGYVRDEYAAAMDRWFPLNRRVVVKNAGHWVHSEQPEVFIEVLRRFLAQA
>NC_008699.1|WP_011755250.1|1903375_1903918_-|CGNR-zinc-finger-domain-containing-protein
MPFTHDTEASLQAAAILANSRLEPDTLTRVEDLDAFYAEFEYTGRHDRDRAELDAVRAIRPALYDLLTADRDHAVEMVNAMLAEAAAVPQLVRHDVWDWHLHAVAPEQDLPTRILVETAMAMIDVIRADEMSRLGVCADDSCDGVVLDLSRNRSKRFCSTACGNRNAVAAYRARRSSREF

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Crispr_ID: NC_008699_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_20

2015565-2015651

Orphan

Consensus_repeat	Method
TTTCCCCGGTGAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_20

>merge|NC_008699|20|2015565-2015651|CRISPRCasFinder
TTTCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAATTTCCCCGGTGAACCGGGGAAACCG

>NC_008699|20|20|2015565-2015651|CRISPRCasFinder
TTTCCCCGGTGAACCGGGGAAACCG	GAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAA
TTTCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011755338.1\|2003394_2003709_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011755350.1\|2020068_2020725_+\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225167
NC_008699.1\|WP_049774563.1\|2023435_2024986_+\|DNA-polymerase-Y-family-protein	unknown	unknown	gnl\|CDD\|176458
NC_008699.1\|WP_011755343.1\|2011313_2012216_+\|ComEA-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|224472
NC_008699.1\|WP_011755347.1\|2016195_2017152_-\|phosphotransferase	unknown	unknown	gnl\|CDD\|270703
NC_008699.1\|WP_011755348.1\|2017232_2019140_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NC_008699.1\|WP_011755354.1\|2025001_2028439_+\|error-prone-DNA-polymerase	unknown	unknown	gnl\|CDD\|235553
NC_008699.1\|WP_011755346.1\|2015819_2016080_-\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|376586
NC_008699.1\|WP_011755351.1\|2020809_2022651_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NC_008699.1\|WP_049774312.1\|2028438_2029731_+\|coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|180172
NC_008699.1\|WP_011755349.1\|2019139_2020051_+\|aminoglycoside-resistance-protein	unknown	unknown	gnl\|CDD\|309685
NC_008699.1\|WP_011755342.1\|2010335_2011190_+\|DegV-family-protein	unknown	unknown	gnl\|CDD\|273257
NC_008699.1\|WP_140403877.1\|2012259_2014539_+\|ComEC/Rec2-family-competence-protein	unknown	unknown	gnl\|CDD\|273036
NC_008699.1\|WP_011755345.1\|2014551_2015544_+\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|236130
NC_008699.1\|WP_011755339.1\|2003854_2005318_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NC_008699.1\|WP_041546471.1\|2007811_2010313_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NC_008699.1\|WP_041547394.1\|2002650_2003322_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NC_008699.1\|WP_140403876.1\|2022797_2023424_+\|DNA-recombination/repair-protein-RecA	unknown	unknown	gnl\|CDD\|280776
NC_008699.1\|WP_041547392.1\|2002016_2002355_+\|MmcQ/YjbR-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|377256
NC_008699.1\|WP_011755340.1\|2005415_2007524_+\|PhoX-family-phosphatase	unknown	unknown	gnl\|CDD\|225752

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011755350.1\|2020068_2020725_+\|MOSC-domain-containing-protein	gnl\|CDD\|225167	COG2258, COG2258, Uncharacterized protein conserved in bacteria [Function unknown].	4.12736e-55
NC_008699.1\|WP_049774563.1\|2023435_2024986_+\|DNA-polymerase-Y-family-protein	gnl\|CDD\|176458	cd03468, PolY_like, DNA Polymerase Y-family. Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.	2.37732e-39
NC_008699.1\|WP_011755343.1\|2011313_2012216_+\|ComEA-family-DNA-binding-protein	gnl\|CDD\|224472	COG1555, ComEA, DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair].	1.00997e-24
NC_008699.1\|WP_011755351.1\|2020809_2022651_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	2.00121e-174
NC_008699.1\|WP_011755348.1\|2017232_2019140_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_008699.1\|WP_011755354.1\|2025001_2028439_+\|error-prone-DNA-polymerase	gnl\|CDD\|235553	PRK05672, dnaE2, error-prone DNA polymerase; Validated.	0
NC_008699.1\|WP_011755345.1\|2014551_2015544_+\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|236130	PRK07914, PRK07914, hypothetical protein; Reviewed.	3.61799e-64
NC_008699.1\|WP_011755342.1\|2010335_2011190_+\|DegV-family-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	2.98867e-82
NC_008699.1\|WP_049774312.1\|2028438_2029731_+\|coproporphyrinogen-III-oxidase	gnl\|CDD\|180172	PRK05628, PRK05628, coproporphyrinogen III oxidase; Validated.	0
NC_008699.1\|WP_011755349.1\|2019139_2020051_+\|aminoglycoside-resistance-protein	gnl\|CDD\|309685	pfam04655, APH_6_hur, Aminoglycoside/hydroxyurea antibiotic resistance kinase. The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation utilising ATP. Likewise hydroxyurea is inactivated by phosphorylation of the hydroxy group in the hydroxylamine moiety.	6.82723e-43
NC_008699.1\|WP_011755347.1\|2016195_2017152_-\|phosphotransferase	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	6.2225e-06
NC_008699.1\|WP_140403877.1\|2012259_2014539_+\|ComEC/Rec2-family-competence-protein	gnl\|CDD\|273036	TIGR00361, Recombination_protein_2, DNA internalization-related competence protein ComEC/Rec2. Apparant orthologs are found in 5 species so far (Haemophilus influenzae, Escherichia coli, Bacillus subtilis, Neisseria gonorrhoeae, Streptococcus pneumoniae), of which all but E. coli are model systems for the study of competence for natural transformation. This protein is a predicted multiple membrane-spanning protein likely to be involved in DNA internalization. In a large number of bacterial species not known to exhibit competence, this protein is replaced by a half-length N-terminal homolog of unknown function, modelled by the related model ComEC_N-term. The role for this protein in species that are not naturally transformable is unknown. [Cellular processes, DNA transformation].	3.78464e-47
NC_008699.1\|WP_011755346.1\|2015819_2016080_-\|30S-ribosomal-protein-S20	gnl\|CDD\|376586	pfam01649, Ribosomal_S20p, Ribosomal protein S20. Bacterial ribosomal protein S20 interacts with 16S rRNA.	1.5321e-22
NC_008699.1\|WP_011755339.1\|2003854_2005318_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	9.32607e-94
NC_008699.1\|WP_041546471.1\|2007811_2010313_+\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NC_008699.1\|WP_041547394.1\|2002650_2003322_+\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	5.35018e-33
NC_008699.1\|WP_140403876.1\|2022797_2023424_+\|DNA-recombination/repair-protein-RecA	gnl\|CDD\|280776	pfam02667, SCFA_trans, Short chain fatty acid transporter. This family consists of two sequences annotated as short chain fatty acid transporters, however, there are no references giving details of experimental characterization of this function.	0.00163048
NC_008699.1\|WP_041547392.1\|2002016_2002355_+\|MmcQ/YjbR-family-DNA-binding-protein	gnl\|CDD\|377256	pfam04237, YjbR, YjbR. YjbR has a CyaY-like fold.	1.01296e-07
NC_008699.1\|WP_011755340.1\|2005415_2007524_+\|PhoX-family-phosphatase	gnl\|CDD\|225752	COG3211, PhoX, Predicted phosphatase [General function prediction only].	1.03633e-174

>NC_008699.1|WP_011755345.1|2014551_2015544_+|DNA-polymerase-III-subunit-delta
MAGPSHPRAADVLGRVTLVTGKEEFLNERTVSAVRAAVRNHDAEAELSETVAGDLSLATLGELAAPSLFSSIRCVVVRALENLPEESVDGLLAYAAAPAEDVALVLVHGGGAKGSGTLTKLRKLETVTESKSGELRPSEFPSFVAAEVRSHGSTIDQEAADFLVQAVGQDLRSLSAAADQLTNDFPGQPLSVEKVKQYFGGRAEAKSFAVADAAFWGRRTAALEELRWALDGGTAPVLVTSAFAGGARGVARYKAAPRGMRDADLAREVGVPPWKLRTIRDQSRGWSDGGIARAIRAIAQADADIKGAASDPSYTLERLVLTITALRDPR
>NC_008699.1|WP_140403877.1|2012259_2014539_+|ComEC/Rec2-family-competence-protein
MLLLGGVAWGGALAARALGWWLLPAALGIGLVAWPLAHGRGRAAVRTTAAVVVVAAAVGAVAVLRLDQVAHSPVARLAQEGAAVRLVGTVTSDPRRTEGRFGEVVTVRLDVREVTGRGATYALVAPVLVLADDDWADLPLGATVTGSGRLSVAEGGDLAAVLGARGPPEVVDDPDVWWDAAAAVRGSIRGAVAHRPDTQRALVPALVDGDDAAVDEALAEDFRTTGLTHLLAVSGTNLTLVVGFVLVLARWCGVRGRLLYAVGALGIVGFVLLARTEPSVLRAAVMGAVALFAMGPEGRERGSRALGVAVLALLLVRPDLAASAGFTLSVLATAGILLLAPGWRDALARWLPRWVAEAIAVPAAAQLACTPVVAAISGQVSLVAVAANLAAAPVVGPATVLGLGGGLAGLVWEPAGRLLGTLAGWCVGWLVVVATRGARLPSAALGWGTGAVALALLTLVVVAIALAGPLLLRRRSTGLGCCALLVATVLVRLPTPGWPPDGWVLVACDVGQGDALVLNAGPHAAVVVDAGPDPTLVDACLDRLDIDSVPLVVLTHFHADHVDGLPGVLDGRTVGAIETTRLLDPPVGVTEVADALAGTGLATGPAPYGATRHVGAVSFQVLWPPADSPTVGPGDGSTANEASVVLLVEVRGVRILLGGDIEPEGQAALARALPGLRVDVLKVPHHGSRYQDEDWLLSLGARVALVSVGADNDYGHPAAETLAPLEAAGVRVLRTDRDGDLAVLADRDGSGAGLSVATR
>NC_008699.1|WP_011755343.1|2011313_2012216_+|ComEA-family-DNA-binding-protein
MPTTRPVRPRPERQEVVARRLALLHAELAGARPPAPPPDPPPAPLAEPLAEPLAEPLAELLAEPPAVPVPGRHASRRPGRSVAVLPATLRGRVALGPAQLAVVALVVALGLGVTSWWVVRGDADRLEAPALEPTGAALVSEGPLSDASPVAAEATASPATVTVDVTGKVRRPGIVVLDTGARVVDALEAAGGARRGVDLSGLNLARVLVDGEQVVVGEPAPTPLGAAAVPTPGAPGGPLVDLNTATQAELEALPEVGPVTAQAILAWRDEHGGFTSVDELLEVDGIGDATLGQLAPFVTV
>NC_008699.1|WP_011755342.1|2010335_2011190_+|DegV-family-protein
MPVVIVTDSTASLPPEVAAERGVRVVPLQVVIGATVYDEGADGATPELVAAALKDWLPVSTSRPGPAALLEVYEQAARDGATEVVSIHLSGQMSGTFESAQLAARDASIPVLPVDTRQVGVATGYAVLAAADVLDAGGDAEAAAEAARARAELSASLFYVDTLEYLRRGGRIGKAAALLGGALSVKPLLQIEDGVVASLERVRTSARALARLEELAVLAAGEVPVDVSVAHLANPERAGQLAERLAHRLEANLEGREVWCGELGAVLGAHVGPGMIAVCVAPRL
>NC_008699.1|WP_041546471.1|2007811_2010313_+|leucine--tRNA-ligase
MSEQTQQAAQPAETAAYDVRAIQDKWLPVWERLDPFRADDSSPREKKYALTMFPYPSGDLHMGHAEVTALHDVVARYWWQRGYEVLNPMGWDSFGLPAENAAIRNDEHPATYTYANIETQYESFKRYAVSFDWSRRLHTSDPEYYRWTQWLFLKFRERGLAYRKSSPVNWCPNDQTVLANEQVVDGRCERCGAEVTKRELTQWYFKITDYAQELLDRLDDLEPTWPARVVTAQRNWIGRSEGAHVDFVVDGRDEPITVYTTRPDTIFGTTFMVVAVDSPLAAELVTDAQRPAFEAYREEIRKETEIERLSTDRPKTGVDLGVTATNPVTGTQIPVWATDYVLADYGTGAVMGVPGGDQRDWEFATEMGLDIVRTTQTPEGFDGEAYHGEGPAINSPAPGADAPLDINGLPVDEAKRATIEFLEQQGTGAGAVNFRLRDWLLSRQRYWGVPIPIIHCDACGEVAVPYDQLPLELPELRGADLKPKGVSPLAAAEEWVNVACPECGGAATRDSDTMDTFVDSSWYFLRYCSPDYTEGPFDVEKAKAWMPADIYVGGVEHAVLHLLYARFFTKVLRDMGMLEVDEPFAAQLNQGIVINQGKKMSKSLGNGVSLGDQLAEFGVDAVRVTLVFAGPPEDDIDWADVSPAGALRFLQRAWRLSGDVTSEAGTPAAGGDVALRRVTARTVHDAAELIESYRFNVMVARVMELVNATRKAIDGAPGPADPAVREATETVAILLSLVAPYVAEEMWERLGHEPTVARVGWPEVDPALLVEEQVTAVVQIQGKVRARLEVAPDISEADLEQLAMADPAVVRAIDGRPVRKVIVRAPKLVNVVV
>NC_008699.1|WP_011755340.1|2005415_2007524_+|PhoX-family-phosphatase
MTTAPAPHDRPLLPVHPVGSGNRHGSRSHLTCYFRCGNACDQPEPNRSDNGHIQDEIAKAVQRRSVLKGAAVGSGALVVSGLVGAAEGAAAAPATAASGSGMAGRGARDSLAKATFTPVAPNKRDAVTTADGFDHHVVIRWGDPVEAGAPAFDPHRQTMSAAMKQFGYNCDYVGVLPVPGDDKRALLVVNHEYTDENIMFPSTGYTSVDIKQVAMANHGMSVVAIKRGLVPGSWYRETNLRATPYNRRIHIHTPFVVDGPAAGDERLRTSADPTGTRVLGTLNNCAGGTTPWGTVLSGEENFNQYFDKSGSLDSRYTAQYARYGITGSGTKGWKDVDSRFDLTTEPHEPHRFGWIVEIDPFAPDEAPRKHTMLGRFKHEGANIVIAKNGRAVAYLGDDERGDYIYKFVSADRFDARRGAAARRRNKTLLTKGTLYVGKFVGDGSEDGVYDGTGQWLPLCTDTESFVEGMSVADVLIFTRLAADKVGATKMDRPEDVEPNLVNGKVYAALTNNSNRGKAGMEADEANPITSSMVRSAIGAPLTSASGNRNGYILELTPSSADHAGTSFTWDLMLVCGDPAAAETYFGGYDKSGVSPISCPDNVSFDDDGNLWIATDGNVLGSNDGIFRVPTKGPERGRVQQFVTMPRGAEACGPLIADQDRSLFFAVQHPGEIDGATFEDQASTWPHSDDFPRPSVCVAFRQA
>NC_008699.1|WP_011755339.1|2003854_2005318_-|NAD(P)/FAD-dependent-oxidoreductase
MHVVVIGAGFGGLGMAHALRQAGVTDVTVLERADEIGGVWRDNTYPGAACDVPSPLYSWSWATNPEWGRRYSPQPEILDYIRRTAAADGLLELVRTGVEVSAVEYDDATSTWRVTTSTGTVTADLVVSAVGQLSNPVVPAIPGASTFAGPAFHSAHWRHDVDLTGKRVAVVGTGASAIQFVPGIVDRVGAITIFQRSAPYVVPKPDQAYRPRHHRLFRRWPGIPAAERRAVYWLTERLNGALAGESPISRPMIAALRAAWRLQLRRQVRDPELRHRLVPDYPIGCKRLLFSNDWYPALDRDHVEVVTDRITGIEPAGVRTADGALHEADVLIWGTGFAATEFLAGIDVRGAGGVSLKELWADGARAHLGLTVPGFPNLFCVYGPNTNLGGSSIIAMMEAQAGWIAQVARRIADGRAHRVAVRRDVWEVYDREMQGRLGESVWAGCDSWYVDGDRITTNWPGLVTEYKQRTATVDWSELQEVDLQRAK
>NC_008699.1|WP_011755338.1|2003394_2003709_-|hypothetical-protein
MFGTGDLGIVRAYAWNSSPSASANLTNNGYTCNRSGGTVNVVHNSTGSYAITFAGLNLNGGNVVVSGYGGTPTWCTIGSWGNSSVSVYCFDAAGPRSTATGRSR
>NC_008699.1|WP_041547394.1|2002650_2003322_+|HAD-family-hydrolase
MASFDTVVLDIDGTLLDSNYHHALAWSRAFDKVLDRHVPAAVIHRHIGMGGDRLVAAVAGDDVEDQHGDEVRERWEKEYDEVIDQTRLFESARELLVAIGAAGLKVVLASSSIPKHAERPLELLRAGEHSDAWTTSEDAEESKPDPELLDAALEKVAGGRALMVGDAVWDVEAADAQRIPTIGLLCGGTGRQELLDAGAVAVYDDPADLIAHLGEALEAANRS
>NC_008699.1|WP_041547392.1|2002016_2002355_+|MmcQ/YjbR-family-DNA-binding-protein
MDDFLGLVAQLPGVARTDRARWSQFDVLGQRFGYLWERTLTVGLKQTIAEQLGLVAERPDVFEVQFTAHGFGWVVVYLERVERDELAELVFEAWRLSAPVEMVAERADRLPV
>NC_008699.1|WP_011755346.1|2015819_2016080_-|30S-ribosomal-protein-S20
MANIKSQIKRNKQNEKRHERNKAVKTGLKTAVRKFREAAEAGDKDTAVALGQDAARKLDKAASKGVIHKNQAANRKSAIAKKAASL
>NC_008699.1|WP_011755347.1|2016195_2017152_-|phosphotransferase
MSAVRRPTTIPHGRTARRLEWPHLPPHIRSLIEQRCGSPVVEAISQGAGFTPGFASVLTCADGSRHFVKAASARAQRMFAEAYREEARKLAGLPVEAPAPRLLWVHDTADPDDWVVLGIEHVPSRQPRRPWRAEDLAACLAMTERLAATLTPPPAGLVLDDFSTEFAGWPALWADVRREHAGRAAELAARFGEVAPGGTLVHTDIRDDNLMLADDGRVLLCDWNWPVVGAAWLDTLILLIGPRGDGLDVDAVLASSPLTRDLDPEAVDIVLALVTGYFLSSAGQPVPPNSPHMRDAQRWQGEVCWEWLCERRGWRRPT
>NC_008699.1|WP_011755348.1|2017232_2019140_+|elongation-factor-4
MAPSPSARRESPVPTNTAPLPGHTDPAIIRNFCIIAHIDHGKSTLADRMLQLTGVVDERSARAQYLDRMDIERERGITIKSQAVRMPWTVPAGNAAGAEPGTYVLNMIDTPGHVDFTYEVSRSLEACEAAILLVDAAQGIEAQTLANLYLAMGADLHIIPVLNKIDLPGANPEKYAAELAGLVGCEPEDVLRVSAKTGDGVADLLNEIVHQTPPPVGEADRPARALIFDSVYDTYRGVVTYVRVVDGRLTHRDRIKMMSTGATHELLELGVISPEQVKATEIGVGEVGYLITGVKDVRQSRVGDTVTTQNHGATEALGGYKHPNPMVYAGLYPIDGDQFGDLREALEKLQLNDAALTYEPETSGALGFGFRCGFLGLLHMEITRDRLEREFDLDLISTAPNVVYHVQMEDGSEVEVTNPSEFPDGKIAEIREPVVRATILSPSDYIGTIMELCQTKRGSLQGMDYLSEDRVEMRYTLPMGEIVFDFFDQLKSRTKGYASLDYERSGEQAADLVKVDVLLQGEPVDAFSAIVHREAAYSYGVMMAGKLKELIPRQQFEVPIQAAIGARVIARENIRAIRKDVLAKCYGGDISRKRKLLEKQKAGKKRMKNIGTVEVPPEAFIAALSNAPTSEKTKK
>NC_008699.1|WP_011755349.1|2019139_2020051_+|aminoglycoside-resistance-protein
MIPPGFSAYAARGADWAAFLDRLPGLVRDLLEEWQLTEDGPATHGFCALVLPVRTAGGRPAVLKMSWPHWEAEHEHLALQRWHGAGAVELLRADPYRYALLLERLHPEDLRDLWDVEACAVVGALYERLHVPAPPQLVTLSSCVARWGVELAALPRDAPLPRRLVEQAASLCRSLAADEATDGRLVHTDLHYENVLAADREPWLAIDPKPLSGDPHYEVAPMLWNRWDDLLSASRSVRDGIRLRFHTLVDVAGLDERRARDWVVVRMLCNALWRLQDPPGVHRSTPTGEYLTRCVTVAKSVQD
>NC_008699.1|WP_011755350.1|2020068_2020725_+|MOSC-domain-containing-protein
MAVVGILHSVNVGRDRDAPYANLGHSGMNKQPVAGRVAVRALGLDGDQVGDTVHHGGVDQAVYVFAREDLDRWAVELGQDIRDGMFAENLTTRGIDVNEAEVGERWRIGTAELEVASVRIPCNDFKSWMGVGGYDNRAWVKRFAATGRPGPYLRVLVEGEVGAGDEIAVVHRPGHGVTVSTMFRALTTETDLLPDLLRVEGLVEQARVTAEKYVAARG
>NC_008699.1|WP_011755351.1|2020809_2022651_+|long-chain-fatty-acid--CoA-ligase
MTAQASSAPNYDAGFVDNLTQNFALQFLDRVAASAEREAFRYPRGEAWESVTWKQAGDLVEKLAAGLLALGLESEQRVGIAAGTRYEWILADLAIMCAAGATTTVYPSTNAEDTAYILSDSECRVVFAEDDEQIAKLKEHRNELPHLGKIVTFDGTTDGDWVIGLDDLAKLGEAYLAEHPGVVEETVRSIAPDQLATLIYTSGTTGRPKGVRLLHRSWVYEGTAIQVQDILHEDDLQFLWLPMAHSFGKVLLSAQLACGFATAIDGRVDKIVDNLGVVKPTFMGAAPRIFEKAHGRIVTMQAAEGGAKEKIFKKAFEVGVKVDQLKREGRSVPLLLGVQHGLFDKLVFSKVRERFGGRVRFFISGSAALNAEIAEWFHAAGILILEGYGMTENAAGATVNHPADYKIGSVGPALPGSEVKIGENDEVLLRGPHVMAGYHNLPEETAATLTADGWLHTGDKGSLDADGFLTITGRIKDLFKTSGGKYVAPSAIESKFKAVCPYASQFLVFGNERNYVVALITLDPDAMAGWAEENGMGGASYTDIVNSDQVQKMVGEYVDELNSRLNRWETIKKWRLLDHDLTIESGELTPSMKVKRNIVEKNNQELIDSLYQG
>NC_008699.1|WP_140403876.1|2022797_2023424_+|DNA-recombination/repair-protein-RecA
MARMHDGVPRLPLETHPVLAGLVQLRAGGSYAVDSASLALALMAGPSRAGGWCAVVGVGDFGAEAAYALGVDLGRTVLVPDPGDQWLEVTAALVDVATVVVISPPGRVTEPVADRLAARLRKRSAALVARERTPGDWPRCEVRLTTREPAWSGAGAGHGHLRSRRLVVEAQRGTAPPRRGALWFPAEDQTYRRAEPLVAATQLVEEAS
>NC_008699.1|WP_049774563.1|2023435_2024986_+|DNA-polymerase-Y-family-protein
MAIWCPDWPVVAALADEGLPTHLPAAVFSANIVQACNAGARAFGVRRGMRRRDAQGRCPELKVYAAIPDRDARAFEPVLAAVEELRPGVAPLRPGLVALRAPGRFYGGEPAAAALVAERLVGLGVWDCRVGVADELFTAEQAARRAAPQDCFVVEPGESVPFLRGLPVEVIEDLPDGRDAVSLLKRLGLRTLGQLGDLAAADVRDRFGRQVAWVHRVVGGDGAELLATRIPPPELACHVDFEPPLDSAETIGFSVRQTADRFVAGLARQHLVCTEVRIEARCEGEAEPSCSRVWLHPRWFGAADLVDRLHWQLQGARSGVPGRGGQVRAPVDRVVFEPVTVVPDAVHADGLWGGTEERVERGIARVQGLLGHEAVVRPVLQGGRCPGDRQAFVPWGERPTGLRPTGPPWPGSIPPPAPSRVLATPWSAEVVGATGRPVAVDERGSVTCAPERFRVDRSGGWQPVAAWAGPWPIDELWWEAPPRRRKVARFQVVGVDGRAWLLTCEEGVWWTEAAYD
>NC_008699.1|WP_011755354.1|2025001_2028439_+|error-prone-DNA-polymerase
MGWSNPPISWGELEKRLSGRLSTPQDPEAPISTRKRKRTRVDVARPAGPVTPYAELHCHSSFSFLDGASGPDHLVLEALRLGLHGLAITDHDGFYGAPLFAETAQLHATNEQSLKTAYGAELSLGLTRPQHGVADPEGGHLLVLARGVEGYHRLAGAITDAQLRGDEKGRPVYDLAELAERGRDHWLVLTGCRKGAVRRALLEHGPVAAAAELDRLTALFGHDNVVVELIDHGYPTDSAHNDLLAALAADHGLRVVATNNVHHARPEQHRVADAMAAVRARRSLAEMDGWLPASGMACLRSGEEMVRRFARYPGAVARSVELADEIVFDLQKATPRLPKDGIPAGHTPSTWLRELTERGFAQRYAGGPLETRARASVEHELRIIAEKDFDGYFVIVHDIVAFARSRGILCQGRGSAASSAVCYALGITAIDPVFYRLPFERFISQHRDEEPDIDVDFDAGRREEVIQWVYERYGRHNAAQVANVVGYRPKMAVRDAAKALGHSPGQQDAWSKQVTSWTTVATRDGGEHPADLHVPAPVVALANGFLGAPRHLGIHSGGMVLTERPIGEVVPIERARMDKRTVLQWDKDGCEYMGLVKFDLLGLGMLSALDHMMRIVEEHLGERWELSTIPKEEPAVYDLLCRADSVGVFQVESRAQIGTLPRLRPREFYDLAIEIALIRPGPIQGGAVHPYIRRATGREEVEYAHPSLVPVLERTKGVPLFQEQLMDMARVLGDCTRDEADLLRRAMGSKRGIERIESIKDKLYEGMARKGLVGEEADAIYLKILSFANFGFAESHALSFAKLVYASSWCKLHYPGAFLAALLRAQPMGFYSPQSLVHDARRHGVEVLRPDLVRSAASADLEPLAVADGPVGLPRCLVDHPERTDWVPGTPDPTPAHRRDAAYAVRLGLDAVRGISAVVAERIVAARAERPFADQADLSRRAGLDARQLEALATAGAFDEAFPGGGLSRRQALWNAGWTESEEHLEGIRAAGPAPMLPEMDEVEVTMADLWATGITPAQHPFGHLRERLRAAGIKSVADTASAEPGRRVHVAGLVTHRQRPGTAGGVTFLNLEDETGMLNVICTVGVWRRHRATAAGAAGMVVRGILERQDGVTNLVADRLAPIESVHPEAGQALRARHRSRDFQ
>NC_008699.1|WP_049774312.1|2028438_2029731_+|coproporphyrinogen-III-oxidase
MGGSVRSGWEDGVVSPSALPPGEPAPEDGSLPASALARVGERGFGFYVHVPFCTVRCGYCDFNTYTAEELGPAGGAPGASRATYAEAAIAEVRRARQVLGDTDLPVNTVFFGGGTPTLLGPADLGAVLAAIGAEFGLADDVEVTTEANPDSVALWDLEELRAAGFTRLSFGMQSAVDHVLRVLDRTHDPLRVPAVVDWARQAGFEQISLDLIYGTPGESVADWDVSVEAALACGPEHVSAYSLIVEEGTALARRVKRGELPMPDEDDLADKYLLVDDRLAAAGLEWYEVSNWARGRDDNTASRCRHNLLYWTGGDWWGVGPGAHSHVGGVRWWNVKHPAAYAERIAAGRSPAHAREVLDEESRRVERVLLELRLRDGLPVEVLDESGRAAVPDLVARDLITELATDDGHRLVPTRRGRLLADAVVRDLLP

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Crispr_ID: NC_008699_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_21

2155124-2155208

Orphan

Consensus_repeat	Method
TTCCCCGGTGAACCGGGGAAACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_21

>merge|NC_008699|21|2155124-2155208|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCGAAACTTCGGGCCAGAGGTTCCAACTTCCCCGGTGAACCGGGGAATCC

>NC_008699|21|21|2155124-2155208|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACC	GGAACTGTTGGGCCGAAACTTCGGGCCAGAGGTTCCAAC
TTCCCCGGTGAACCGGGGAATCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_140404199.1\|2162400_2164881_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341246
NC_008699.1\|WP_148217945.1\|2165980_2167537_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
NC_008699.1\|WP_041546486.1\|2155225_2155546_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|225209
NC_008699.1\|WP_041547452.1\|2154772_2154988_-\|ferrous-iron-transport-protein-A	unknown	unknown	gnl\|CDD\|377199
NC_008699.1\|WP_140404198.1\|2146782_2147193_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011755465.1\|2150183_2150561_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368388
NC_008699.1\|WP_041546488.1\|2159605_2161054_+\|RNB-domain-containing-ribonuclease	unknown	unknown	gnl\|CDD\|223631
NC_008699.1\|WP_011755475.1\|2161202_2162423_+\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|224837
NC_008699.1\|WP_011755462.1\|2147197_2148049_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_008699.1\|WP_041546487.1\|2156764_2157508_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224495
NC_008699.1\|WP_011755470.1\|2155597_2156731_+\|Nif3-like-dinuclear-metal-center-hexameric-protein	unknown	unknown	gnl\|CDD\|225860
NC_008699.1\|WP_011755466.1\|2150725_2152291_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|235730
NC_008699.1\|WP_011755477.1\|2164922_2165984_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NC_008699.1\|WP_011755472.1\|2157504_2158710_+\|bifunctional-RNase-H/acid-phosphatase	unknown	unknown	gnl\|CDD\|180903
NC_008699.1\|WP_011755473.1\|2158831_2159587_-\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|234999
NC_008699.1\|WP_011755467.1\|2152287_2152833_-\|NifU-family-protein	unknown	unknown	gnl\|CDD\|376458
NC_008699.1\|WP_011755464.1\|2148712_2150239_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|273593
NC_008699.1\|WP_011755468.1\|2152829_2154776_-\|ferrous-iron-transporter-B	unknown	unknown	gnl\|CDD\|223447
NC_008699.1\|WP_011755461.1\|2145857_2146562_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011755463.1\|2148056_2148728_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_140404199.1\|2162400_2164881_-\|AMP-binding-protein	gnl\|CDD\|341246	cd05922, FACL_like_6, Uncharacterized subfamily of fatty acid CoA ligase (FACL). Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	3.24321e-115
NC_008699.1\|WP_148217945.1\|2165980_2167537_-\|iron-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	1.80423e-91
NC_008699.1\|WP_041546486.1\|2155225_2155546_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	4.36988e-24
NC_008699.1\|WP_041547452.1\|2154772_2154988_-\|ferrous-iron-transport-protein-A	gnl\|CDD\|377199	pfam04023, FeoA, FeoA domain. This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	2.87587e-15
NC_008699.1\|WP_011755465.1\|2150183_2150561_-\|hypothetical-protein	gnl\|CDD\|368388	pfam05327, RRN3, RNA polymerase I specific transcription initiation factor RRN3. This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.	0.00048856
NC_008699.1\|WP_041546488.1\|2159605_2161054_+\|RNB-domain-containing-ribonuclease	gnl\|CDD\|223631	COG0557, VacB, Exoribonuclease R [Transcription].	1.49432e-78
NC_008699.1\|WP_011755475.1\|2161202_2162423_+\|dienelactone-hydrolase-family-protein	gnl\|CDD\|224837	COG1926, COG1926, Predicted phosphoribosyltransferases [General function prediction only].	1.07854e-45
NC_008699.1\|WP_011755462.1\|2147197_2148049_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.26849e-51
NC_008699.1\|WP_011755470.1\|2155597_2156731_+\|Nif3-like-dinuclear-metal-center-hexameric-protein	gnl\|CDD\|225860	COG3323, COG3323, Uncharacterized protein conserved in bacteria [Function unknown].	4.51722e-40
NC_008699.1\|WP_011755466.1\|2150725_2152291_+\|AMP-binding-protein	gnl\|CDD\|235730	PRK06187, PRK06187, long-chain-fatty-acid--CoA ligase; Validated.	5.86879e-168
NC_008699.1\|WP_011755477.1\|2164922_2165984_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	9.50142e-112
NC_008699.1\|WP_011755472.1\|2157504_2158710_+\|bifunctional-RNase-H/acid-phosphatase	gnl\|CDD\|180903	PRK07238, PRK07238, bifunctional RNase H/acid phosphatase; Provisional.	8.95089e-153
NC_008699.1\|WP_011755473.1\|2158831_2159587_-\|peroxide-stress-protein-YaaA	gnl\|CDD\|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	3.49185e-69
NC_008699.1\|WP_011755467.1\|2152287_2152833_-\|NifU-family-protein	gnl\|CDD\|376458	pfam01106, NifU, NifU-like domain. This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.	5.09835e-20
NC_008699.1\|WP_011755464.1\|2148712_2150239_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	2.61387e-57
NC_008699.1\|WP_011755468.1\|2152829_2154776_-\|ferrous-iron-transporter-B	gnl\|CDD\|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	1.12514e-151
NC_008699.1\|WP_011755463.1\|2148056_2148728_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.89124e-85
NC_008699.1\|WP_041546487.1\|2156764_2157508_+\|hypothetical-protein	gnl\|CDD\|224495	COG1579, COG1579, Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only].	3.85665e-26

>NC_008699.1|WP_041547452.1|2154772_2154988_-|ferrous-iron-transport-protein-A
MPAGASGTIVGVAADAEPHVARRLVDLGLVPGTEVTVVRRAPLRDPTLYRFADTSMCLRAAQARLVTVAPA
>NC_008699.1|WP_011755468.1|2152829_2154776_-|ferrous-iron-transporter-B
MSAHCAPGPATSTDTGRAMVALVGAPNAGKSTIFNALTGLRVKTGNYPGVTVGRSQGTCALTDGTAVEVEDLPGTYSLEPISIDERIVVDLLHGRLDGVGEPDAVLVVADATTLRSSLRLLAGVLALGRPTALVLTMHDELVARGGRVDLDRLTRALGVPVVVADGRRRAGAAELVDLLRDRPAWPAPVVPPPTDTDECTAWISSVLTTAAYRSAQESALTARIDRVLLHPVAGVAVFFAVMFGFFQTIFALAAPAQDAIGTGIAALAATVRDTFGDSAPVRLVTDGLLGGVGGVLVFVPQIALLFVLIAALEQVGYLSRAAFLMDRVMALAGLEGRAFVALLSSFACAIPGIMATRTMPSARERLATMLSVPLVTCSARLPVYTLLISMLIPAQASWWGVSARGTTMFGLYLLGAVSMMLAARVATLVGGGRHPVMPFTMEMPPYRLPALRSVVVAVWLPVKGFLRKMGTVIVVSTIVLWALLNLPVHSAAELRADGVDPADGTAVAAYTMEHSVAAGIGRAAAPVFDPLGLDWRTNVAVISSLAARETFVATMGQITAAGDPDQPAQALRDTTFDSGPKAGQPVFTSATLAALLVFFVYALQCMATIATLRRETGGWQWPLTVFGAYFALAWTMALLARTVVGAFA
>NC_008699.1|WP_011755467.1|2152287_2152833_-|NifU-family-protein
MSLAAPTVDLIALHPEPGATPDEVRWVVPDAPLPAPGRAAEVPAELGSLIADGTLVEVQVLPGCIATRAASAGEWRRCGPRVRQAVAAALADPGRWRTEAGDAPDDRDLIEAVHRLLAGDVGDYVRSHGGAIELVDVRDGVVGVRLRGACHGCPASAFTLRARFERRLRAECPGLVAVEAR
>NC_008699.1|WP_011755466.1|2150725_2152291_+|AMP-binding-protein
MIVPFSVSDFIDRAVQVYGERVGVVDEPDQPASPLGAGGQLTYGELGSLARRQAARLDELGLDVGDRVAIVSHNSARLLTSFFGVSGFGRVLVPVNFRLRPDEVHYIVKHSGARVLLIDPELEETLEDVPAEFKFVLGRDEDMFAAAPADGGVEPRPWEPDENATACINYTSGTTARPKGVQITHRNIWVNAATFAMHAGVTDRDVYLHTLPMFHANGWGMPYAMTGLGVKQVVIRKIDGAEILRRVRDQGVTVMCAAPAVAAAVLDAAQTWEGEIPGRDRVRIIMAGAPPPTKTVIRVQEELGWEFIQIYGLTETSPLLTINRTREEWDDLSAEERAIRLTRAGAPALGVRLAISDHEENSGEVLARSNVVLDGYWQQPEETERALADGWFHTGDGGSLGDDGYLTISDRKKDVIITGGENVSSIEVEDVLFSHPAVAEVCVIGVPSDKWGETIKALVVLAEGASATEAELIAWCKEKAAGYKAPTSVEFRDELARTATGKLQKFKLRAPYWEGRDRQVN
>NC_008699.1|WP_011755465.1|2150183_2150561_-|hypothetical-protein
MKTLWKVLLALALVVPLAAYVTGSLVASAADDPAPRPPIVIQDAGRSAAPSQTPSSSPSASDDVGEVELDPDDLDDDSDDFGRDDDRFDDHGDDHGDDDHSGPGGGGDDHSGSGSDDSGHGSSDD
>NC_008699.1|WP_011755464.1|2148712_2150239_-|HAMP-domain-containing-histidine-kinase
MTTAAAAATTAATGAATTDPTTEGTDPRRSARPTSRPGVSVRVRITAAVALLGALALTGAGAIVYAVEGQRVEEQQLAEIDQELAELGKLHKRGLNPDTGRPFDSVGTMLDTFLVRNVPDENEILVSWFDGRPQKASPTAAFAETQLFRDTAGALVDDGGGSARVDVPGYGEALITVQPVRSTREAGALVIVTYLTEARAELRDTMRTYATVALLSLLLVTAAAAWLSGRLLAPLRTLRETADDISGSDLSRRLPVTGHDDITALTRTVNGMLDRLEAAFVGQREFLDDAGHELRTPLTVLRGHLELLDTGDPAEVAETKELLLDEVDRMSRLVGDLILLAKSDRPDFLQLRPVDLAGLTADVLAKARGLGDRDWQLDAAADVVVVGDEQRLTQALLQLADNAVKHTGPGDTVAIGSSYDDGRARLWVRDTGPGVPPEQRGLIFERFGRGAVMPGDEGFGLGLSIVSAIARSHGGGVEVEDAEETAPRGARFVMTLPAPPKEDPWPGS
>NC_008699.1|WP_011755463.1|2148056_2148728_-|response-regulator-transcription-factor
MARILIVEDEERIASFLAKGLRADGHVTTCVADGREGLDLALGGDVDLVVLDIGLPGMDGFEVLDQLRSQGSTVPVIVLTARDSVGDTVSALEGGADDYMPKPFRFAELLARVRLRLRQSADAGGASREDVLQSGRVKLDVRTRRAVVEDRQVDLSAREFSLAEIFMVNAGQVLSREQLLDHVWGMDFDPGSNVVDVYVGYLRKKLGADTIATVRGMGYRFNR
>NC_008699.1|WP_011755462.1|2147197_2148049_+|serine/threonine-protein-kinase
MPNPSSWGFAEGDAITAELTAVRRLGGGSAYEAYLAFDELTYLPVVVKLVRPDLVRDEHALRGLTREVEALATVNHPVVVRGLRHEPGGPRPHVVLEQVDGPRLSTLLRRYGPLQEQQYLPLAIEVASALHYLRHLGWVHLDVKPSNVIMGAPARLIDLSVARPVADAADTRQVGTDAYMAPEQADPERYGAPGPASDVWGLCATLFEAVAGYRAFDGHGFPQLDEDPYELPDRTPTEVVKVLYAGLDRAAANRPLPHELAEALEPVLDRLPAARLAGAFKAS
>NC_008699.1|WP_140404198.1|2146782_2147193_+|hypothetical-protein
MNKLMTSGTLGLASLVTTGLIAWQAPLALADQGSDDSGRDDRHHSKAFKRDDDSQAVVTTVDDDDDDDTGLDNGTNTGTNTGADAGTNTGTRTRGGDTDHSRDASVRDLTSDGPGSGNVDHSRHHTNDGTRHNTRG
>NC_008699.1|WP_011755461.1|2145857_2146562_-|hypothetical-protein
MWARALVLGAVMLGTGTVSHASAGGRIPHPVALLVLTAALVVLAGRFLLGPASTRRIVVLVVAGQGLAHTALSALAGHRDDGGTAAPRHLSVPATSLPVDADGRRVGSLLDAYTSMPAMAGHDRPGVPTAPLTHLLHHLADQGPLMLAAHLAAAVALGLLLAVGERALWALLHLAAARVVVLAAARRSAAATLAVLRGAATAPRPRPRRAGFTPIPRLDRPALSHRGPPALLAS
>NC_008699.1|WP_041546486.1|2155225_2155546_-|antibiotic-biosynthesis-monooxygenase
MPVVKINAISVPPQAHEELEKRFAGRAHTVDATPGFLGFQLLRPVRGEDRYFVVTQWADEESFAAWRDGDARAAHASQAGERRDPVSTGADLLEFEVVLDVPPAAG
>NC_008699.1|WP_011755470.1|2155597_2156731_+|Nif3-like-dinuclear-metal-center-hexameric-protein
MPALEDVVDLLHGWYPPHTADSWDAVGLVYGDPAAPVRKILFAVDPVLPVAQEAAEWGADLLVTHHPLFLKAVHGFPATTPKGRTLAALAGAGCALLAAHTNADQAVGGVSEALARTLGLSDPEPIVPASAGLLDKLTVYVPAADADRLREVLAQAGAGRIGDYDHASFSSPGEGRFRPLEGAHPAIGSVGEVEVVDEVRVEVVVPRDRRAAVVRALLTAHPYEEPAYDVVELADPGLATTGTGRIGTVPETTLEGFAAHVAGALPATAQGVRVAGDPQRPVRRVALCGGAGDFLLDAVARTDADVYVTSDLRHHPASEFAERGGPALVDVAHWAAEWTWLPVVAARVAEALVAEGTGDTVETRVSTIRTDPWRFRV
>NC_008699.1|WP_041546487.1|2156764_2157508_+|hypothetical-protein
MKADPSAQLQLLDVQALDARADLLRHQRTSLPELAEIATLRTSRTELDNRARDARIAVDDLTVEQEKVDADAEAVKARRRRDRDRMDQGLVTNPKDLERMQHELESLERRIASLEDEELEVMARLEDAQRDLDGLTAQVAEADQRLAELAAARDERLAAIDAELGSVLAERAPAVEGVPADLLALYDRLREQKGGVGAAELRQRRCTGCQLGIDNAELAVIKAAPADEVIRCEECQRILVRTPESGL
>NC_008699.1|WP_011755472.1|2157504_2158710_+|bifunctional-RNase-H/acid-phosphatase
MTRSVVVEADGGSRGNPGPAAYGAVLRDAETGAVIAEDATAIGIASNNVAEYSGLIAGLRLAERFAPDADIEVRMDSKLVVEQMSGRWKIKHPDMRPLATEASRLAPFGTTYTWVPREQNKHADRLANEALDGLRSGVSVPAEAAEPDSLIEEVESPEERAEAGQEQPASIQSQARGWGGGGTPTTVVLVRHGVTPHTTEKRFSGGLASANPGLSEEGRAQVRAVADWLAPLAERVDVVLSSPVRRTRESAELVAERLGQEVRVEPGFAEMEFGAWDGLTFAEVGERHPEDLTAWLGSLDVAPGGPQGGGESFRVVQERVLAGLSRLLDEHAGRTVVVVSHVTPIKTLVAHALDAPLEAVFRMELTPASVTVVSYYDDRPSLRMYNALPPGNDVFGAASTW
>NC_008699.1|WP_011755473.1|2158831_2159587_-|peroxide-stress-protein-YaaA
MLILLPPSEGKAAARRGKPLDLGTLAFPALNPARERVLATLEELCAGDPAVAAKTLGLGGTQLDLVDLNARLRTAPTARADQVYTGVLYDALDVNTLSAAAKRRAASRVAVTSSLFGLLRTADRIPAYRLSGDTTLPGLGAVAGVWREQLGPVVTEAVGNGLLVDLRSGTYVAFWRPAGVRTATVRVLHESGGTRKVVSHFNKATKGRIVRALLEAGADPRTPARLAEALRDLGWVVEEDGPRLDVVVGEL
>NC_008699.1|WP_041546488.1|2159605_2161054_+|RNB-domain-containing-ribonuclease
MPSSRVVRVRSVRDEVAAAALRDGIARIQADLEVTPDFPAEVEQAAAAAAGAPRLPDLDRTDLPFVTIDPPGSMDLDQALHLERDGEGYVVHYAIADVAAFVAPGDPIDVEAHRRGETLYGADSKIPLHPPALSEDAASLLPDQVRPALLWTIRVDADGGRTAVHVERARVRSTARLSYEEAQRAIDAGTGPESLALLREVGELRLAREAARGGVSLPLPEQDVDVEGDHWRLEFREQLPVEQWNAQISLLTGFAAAALMVYARVGLLRTLPPPDPRDVQRLHRTARALGIEWPAEQLYPDFIRSLDPSRPSHAAMVNASARLLRGSGYVAFDGETPADPQHAALASEYAHVTAPLRRLGDRYAGEVCLALCAGTDVPDWVLAALPGLPKTLQSSGARARSYERQIVDLVEAGVLRDRVGEVFDGVVVDVDEKDPGRGVVVIQDPAVESRLVGPAPLPLGTDVRARLTTADLTTRTVELTVE
>NC_008699.1|WP_011755475.1|2161202_2162423_+|dienelactone-hydrolase-family-protein
MFLDRIDGGRRLAALLSHFTGTNVVVVGLPRGGVPVAAEVAYQLRAPLDVIVVRKPGLPGEPELTDPERAALRERATQLRSGRSGLDLSGRVALIVDDGIATGATAAAACRVAREVGASYVVVAAPVVAPGIDARDLDADEIVYVEMPARFTSVAAHYQDFRPTTDEQVVRLLDGGRGDGVDPSGQTVRIPAGGAILAGTLRIPDHPRGVVLFAHGSGSSRHSLRNVKVARRLTNAGFATLLLDLLSPAEESSCDRVFDVDGLAHRLITATNWLAGVPALEGLPIGYFGASTGAAAALRAAAALDGRITAVVARGGRPDLAGDALGRVAAPTLLVVGGADPTVLELNRWAAARMHCPSQVTIVPGATHLFSEPHSLERVAELATEWFSRHLTTQAAAGTVSLGVSC
>NC_008699.1|WP_140404199.1|2162400_2164881_-|AMP-binding-protein
MDLTLLGGHPDDPALVTGDRTVTYAELAALVQRRALELDDPGRLLLLEMANDLPSVVTYLAALALHRPVVIATPGAHDDIARTYRPALDADAPPPLHPDLAVLLSTSGSTGSPKLVRLSRANVVANARSIADYLGIRRSDRALTSLPLHYCYGLSVLNSHLVAGAAVVLTDLSVADECFWDLARTHRATTFAGVPYTFDLLDATGFADRDLPHLRYVTQAGGRLAPETVVRYAELGQRRGWDLFVMYGQTEATARMAYLPPTLAPTRPEAIGVAVPGGTLRVDLDGPGREGLPADVGELVYGGPNVMMGYAHGPADLARGAELTELRTGDLARRGPDGLWEVVGRLNRTAKVFGLRLDLDRIERRLATAGAPARAVVVGEGLHLFTTRPRDRRVLPTHLARIAGIPAGTVTAHVVETVPTTASGKCDYAALRRQAEAALALAEPDAGSEAAPAYGDVTGLRDLYAVLLGRPDATAQDTFVGLGGDSLSFVELSTRLAARIGHLPADWPHRSIESLALESRPARRFTTPVELGVVLRAVAIILIVVTHVDVVHLLGGAHVLLALVGYHLARFGLAVDGRRTRTRRLLVGLAGVAVPASLWIGGAALLTGEYRPATALYLNGVVGESRWSDDWQFWFLDVLVWGTLAVALALAVPWVDRRQRRSPYAVALVALVAALGLRYATVGVSADLTEKYTVAGSLWLIALGWAVAEARTRTQRLVVAAVAALGLVGFFPGEPSRTAIVGIGVLLLLWARPVPVPTVLAAPLRVVAGASLWIYLTQWQVYPGLEAAGRPALAIGASLAVGVACCCAYTRLERAVRPRLSRRRRG
>NC_008699.1|WP_011755477.1|2164922_2165984_-|ABC-transporter-ATP-binding-protein
MTKALEVSGLTVGYGDHTVLHAVDLVVEDGITAVLGVSGCGKSTLLRTVAGFLRPRAGTIRLAGTEVSSPTRSVAPRGRNIGYVPQEGALFPHLDVAHNIAFGLPRGQRRRPRERVAEMLELVDLPAGLATRYPHHLSGGQQQRVALARALAARPSLVLLDEPFSSLDAGLREETGRAVVDALRATGSAALLVTHDQGEALSLADQVAIMSGGHFLQAAAPRTIYLSPANEAVASFLGHAALIRGEVAPGEPSRATCVLGSVRVTGHPAPGPVTLALRPEQVQVRPAESGEGVAAEVIDVSFFGHDATVRARLDGHPDLVIARTPADTLPRPGDHVRLVVTGEVRCFAPGAGA
>NC_008699.1|WP_148217945.1|2165980_2167537_-|iron-ABC-transporter-permease
MPGTEPAARTHPQRPEPAPPFLLALGALVTVACLIPLGYVVWSVADVGLAEARDYLFRPRIGELLWNTSRLLVGGVALSVVLGVGGAWLVERTDVPGRGWWHGLMCAPLAVPAFVNGYGWVSMTHAVQSYGGAALVVSLSYFPFVYLPTVAALRRLDPSLEEVSASLGQRPLATFLRVVLPAISPAVLGGALLVGLHLLAEYGALQLLNYPTLTTAILQQYGTSFNGPAASLLALVLVVFCLALLAVELLLRGRGRRARVGSGAARAADPHRLGRGRLPAAGGLAALVVLALGVPLLNLARWLVRGSSTRWDLPDLTSAIATSVGLAVLAGLVATAAATPVAWLSVRHRGGLTTTLERATYTASAMPGIVVALALVTVSIRAVPALYQTVPLLVIGYVILFLPRAVVSLRPTMELAPPVLEDVARSLGCGRTGVGLRVTAPLIAPGLAAGFALVSLAVSTELTATLLLAPIGTDTLSTEFWSKASSVAYGAAAPYALALVVLSVPATWLLSRVTVGAR

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Crispr_ID: NC_008699_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_22

2525300-2525384

Orphan

Consensus_repeat	Method
GCACGCAGCGCGTGCGGCCTGTCGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_22

>merge|NC_008699|22|2525300-2525384|CRISPRCasFinder
GCACGCAGCGCGTGCGGCCTGTCGTGCGTTCGGGTGGGTGGTAGCGCGGCTCTGCCGTTTGCACGCAGCGCGTGCGGCCTGTGTC

>NC_008699|22|22|2525300-2525384|CRISPRCasFinder
GCACGCAGCGCGTGCGGCCTGTCGT	GCGTTCGGGTGGGTGGTAGCGCGGCTCTGCCGTTT
GCACGCAGCGCGTGCGGCCTGTGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011755819.1\|2528912_2529692_+\|inositol-monophosphatase	unknown	unknown	gnl\|CDD\|223559
NC_008699.1\|WP_041546538.1\|2525400_2525586_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011755810.1\|2518791_2519856_-\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176187
NC_008699.1\|WP_011755823.1\|2533225_2533984_+\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NC_008699.1\|WP_011755818.1\|2528391_2528916_+\|HIT-domain-containing-protein	unknown	unknown	gnl\|CDD\|238606
NC_008699.1\|WP_041546537.1\|2515218_2516238_-\|pyruvate-ferredoxin-oxidoreductase	unknown	unknown	gnl\|CDD\|239471
NC_008699.1\|WP_011755809.1\|2518162_2518804_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_140403993.1\|2524644_2525049_-\|SsgA-family-sporulation/cell-division-regulator	unknown	unknown	gnl\|CDD\|377399
NC_008699.1\|WP_011755822.1\|2532003_2533134_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380650
NC_008699.1\|WP_011755816.1\|2525865_2527872_+\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237050
NC_008699.1\|WP_011755812.1\|2520446_2521682_+\|type-II-toxin-antitoxin-system-HipA-family-toxin	unknown	unknown	gnl\|CDD\|377920
NC_008699.1\|WP_011755807.1\|2516219_2517425_-\|2-ketoisovalerate-ferredoxin-oxidoreductase-subunit-alpha	unknown	unknown	gnl\|CDD\|181403
NC_008699.1\|WP_011755821.1\|2530429_2531593_-\|xylose-isomerase	unknown	unknown	gnl\|CDD\|237170
NC_008699.1\|WP_049774578.1\|2527882_2528329_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_008699.1\|WP_011755813.1\|2523834_2524659_+\|aminotransferase-class-IV	unknown	unknown	gnl\|CDD\|238800
NC_008699.1\|WP_011755820.1\|2529784_2530405_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|367760
NC_008699.1\|WP_011755808.1\|2517417_2517990_-\|2-oxoacid:acceptor-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|274014
NC_008699.1\|WP_011755824.1\|2533980_2535240_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226669
NC_008699.1\|WP_011754492.1\|2521859_2523098_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_008699.1\|WP_011755811.1\|2520112_2520457_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011755819.1\|2528912_2529692_+\|inositol-monophosphatase	gnl\|CDD\|223559	COG0483, SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism].	6.93715e-49
NC_008699.1\|WP_011755810.1\|2518791_2519856_-\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176187	cd05284, arabinose_DH_like, D-arabinose dehydrogenase. This group contains arabinose dehydrogenase (AraDH) and related alcohol dehydrogenases. AraDH is a member of the medium chain dehydrogenase/reductase family and catalyzes the NAD(P)-dependent oxidation of D-arabinose and other pentoses, the initial step in the metabolism of d-arabinose into 2-oxoglutarate. Like the alcohol dehydrogenases, AraDH binds a zinc in the catalytic cleft as well as a distal structural zinc. AraDH forms homotetramers as a dimer of dimers. AraDH replaces a conserved catalytic His with replace with Arg, compared to the canonical ADH site. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.72569e-169
NC_008699.1\|WP_011755823.1\|2533225_2533984_+\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	1.55136e-107
NC_008699.1\|WP_011755818.1\|2528391_2528916_+\|HIT-domain-containing-protein	gnl\|CDD\|238606	cd01275, FHIT, FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.	1.6933e-57
NC_008699.1\|WP_041546537.1\|2515218_2516238_-\|pyruvate-ferredoxin-oxidoreductase	gnl\|CDD\|239471	cd03376, TPP_PFOR_porB_like, Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea and some hyperthermophilic bacteria. PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea, anaerobic bacteria and eukaryotes that lack mitochondria (and therefore pyruvate dehydrogenase) use PFOR to oxidatively decarboxylate pyruvate, with ferredoxin or flavodoxin as the electron acceptor. The 36-kDa porB subunit contains the binding sites for the cofactors, TPP and a divalent metal cation, which are required for activity.	2.35141e-133
NC_008699.1\|WP_140403993.1\|2524644_2525049_-\|SsgA-family-sporulation/cell-division-regulator	gnl\|CDD\|377399	pfam04686, SsgA, Streptomyces sporulation and cell division protein, SsgA. The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division.	2.37584e-34
NC_008699.1\|WP_011755822.1\|2532003_2533134_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|380650	cd19995, PBP1_ABC_xylose_binding-like, periplasmic xylose-like sugar-binding component of the ABC-type transport systems. Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	6.9265e-91
NC_008699.1\|WP_011755816.1\|2525865_2527872_+\|threonine--tRNA-ligase	gnl\|CDD\|237050	PRK12305, thrS, threonyl-tRNA synthetase; Reviewed.	0
NC_008699.1\|WP_011755812.1\|2520446_2521682_+\|type-II-toxin-antitoxin-system-HipA-family-toxin	gnl\|CDD\|377920	pfam07804, HipA_C, HipA-like C-terminal domain. The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.	6.2465e-56
NC_008699.1\|WP_011755807.1\|2516219_2517425_-\|2-ketoisovalerate-ferredoxin-oxidoreductase-subunit-alpha	gnl\|CDD\|181403	PRK08367, porA, pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed.	1.1728e-112
NC_008699.1\|WP_011755821.1\|2530429_2531593_-\|xylose-isomerase	gnl\|CDD\|237170	PRK12677, PRK12677, xylose isomerase; Provisional.	0
NC_008699.1\|WP_011755813.1\|2523834_2524659_+\|aminotransferase-class-IV	gnl\|CDD\|238800	cd01559, ADCL_like, ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.	7.21365e-64
NC_008699.1\|WP_049774578.1\|2527882_2528329_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.32995e-10
NC_008699.1\|WP_011755820.1\|2529784_2530405_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	0.000677651
NC_008699.1\|WP_011755808.1\|2517417_2517990_-\|2-oxoacid:acceptor-oxidoreductase-family-protein	gnl\|CDD\|274014	TIGR02175, Pyruvate_synthase_subunit_PorC, 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family. A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins (H. pylori) used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes the gamma subunit. In Pyrococcus furious, enzymes active on pyruvate and 2-ketoisovalerate share a common gamma subunit.	2.44843e-60
NC_008699.1\|WP_011755824.1\|2533980_2535240_+\|ABC-transporter-permease	gnl\|CDD\|226669	COG4214, XylH, ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism].	7.85365e-74
NC_008699.1\|WP_011754492.1\|2521859_2523098_-\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	7.62393e-23
NC_008699.1\|WP_011755811.1\|2520112_2520457_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.45149e-09

>NC_008699.1|WP_140403993.1|2524644_2525049_-|SsgA-family-sporulation/cell-division-regulator
MAQDLSLQCLDASGHAVDLPATFGYDPADPWAVWITFRGPRDEVRWAVGRDLLLQGLTDPAGEGDIQLWPSIDEHGRAAVVMELCSPDGRLVTQLHTHELYRFLTRTLAIVPVGSEAIDLDDLVAELTGISRAE
>NC_008699.1|WP_011755813.1|2523834_2524659_+|aminotransferase-class-IV
MRAWINGHLLPDATAPAVPVTDHGLTVGDGVFEAVKVVDGRPFALDRHLERLHRSAHGLGLAGIDEDAVRRGVAALLTGEPLALGRLRITCTGGPAPLGSGRGDAAPTLIVVLDTMTAWPDTTSVATVPYPRNERGALAGLKTTSYAENVVALAAARERGASEAIFANLAGHLCEGTGSNVFYVLDGELRTPTLASGCLAGVTRALVLEWYGAREVDEPIEVVERASEVFLVSTTRDVQAVARWDEREVPAPGPVTTAVREVWRSREPELLLRA
>NC_008699.1|WP_011754492.1|2521859_2523098_-|IS110-family-transposase
MEVIHVRCAGMDVSKKDAKVCVRHAGAGRRKTVETVTTWTSMTGQILALREHLIAEQVTCVVMEATGDYWKPFYYLLEDLPGVEVMLVNARHVKTLPGRKSDVADATWLAQLGAHGLVRASFVPPEPIRQLRDLTRARTAITRERGREVQRLEKLLEDAGIKLSAVASDIMGVSGRAMLEALIAGDRDPAGLADLARRRLRSKIPELTEALAGRFTEHHAFLARVHLDLIDRHTAAVEQLTERIEVVIEPFQGFHDLICTIPGISTITADIITAETGADMTRFPTAKHLASWAGTTPGSNESAGKVKSSRTRPGNPYLQGALGAAAMACSQNRTTYLGARYRRIASRRGPLKANVAIQHSMLIAIWHMGTTGTLYDDPGGEFFNRLHPDRTKMRAISQLEAMGYRVTLDHAS
>NC_008699.1|WP_011755812.1|2520446_2521682_+|type-II-toxin-antitoxin-system-HipA-family-toxin
MTSEPYRARRVFVWTWLPGESTPVVAGAVDRVGADRLDFTYARSYLDNERAISLYTPELPLRRGTQEPMDGLTVAACLRDATPDSWGERVIGNRLGSGDTELSVETYMLESGSNRLGAIDFQESPEDYSPRVDTAGLDELYDAAEKVLAGEPLNPAIGDALMNGTAIGGAHPKVLISDDSGVEHLAKLSVSSDVHPWVRAEAVAIELARLCGIEVPKAHVIKSVGREVLLIERFDRPPGGRRRHVVSGLTMLGFDALLGARYGSYPEMLDVLREWGRAPQDIGHRLFERIVFNIAVGNNDDHARNHAAFWDGTSLELTPAFDLTPQPRSTDTSAQAMAIGRDGSRASRFSVCVAAAADYGLSRAEAGQIVERIVATVENHWSEAADAAGLSEADRNLLWKRSILNRSSFYD
>NC_008699.1|WP_011755811.1|2520112_2520457_+|helix-turn-helix-transcriptional-regulator
MARIRVSPRRGAADAAVVLGQQVKAARVARRWTAVELAERIGVDRRTVAAIEAGDPGVSLGNAFNAADILGVPLFGAEDRAELARLRREGRDRLALLPTRVDKPRKQAEPDDDF
>NC_008699.1|WP_011755810.1|2518791_2519856_-|NAD(P)-dependent-alcohol-dehydrogenase
MQALRLRAWKSDPVLEDVAVPEPGPDEVLVQVGGAGACHSDLHLMHEFEPGTLPWSPPFTLGHENAGWVHTVGTGVTGLEPGQPVAVVGAWGCGVCDRCRAGVETYCERPDLAPVPSGGGGLGLDGGMAEYLLVRGARHVVPLPEGLDPVTAAPLTDAGLTPYHAVRRSLAKLAPGATALVIGVGGLGHLGVQVLRAVTAARVIAVDPRSSALSLASKVGADATLTPGPATAAEVRELTHGVGADVVLDFVGSDDTLALAAQAVRQLGDLTVVGIAGGSLPFSFFGVPYECSVQTTYWGNRTELVEVLDLAARGLLTAHTTTFELAQAPEVYAELARGEIDGRAVVVPNRAYRP
>NC_008699.1|WP_011755809.1|2518162_2518804_+|hypothetical-protein
MKGTPERVIESRAMRRYRAGWNGVVILLVAVGTAAGSVAIGWAPLVGITACLAVLGAAFGVAWVEPDGDRRLAATTGARYGAAAATILGGFPALIDGWTALVLITTTLTAPPILEQLRRSLHGKSAPGAVDDPTRLSERDLAERWRSSYDEVHRADATPRELLDVIAERGRLLDELERRDPRRFRAWLAATAETKPGPRPGSKPGSQPGAQGR
>NC_008699.1|WP_011755808.1|2517417_2517990_-|2-oxoacid:acceptor-oxidoreductase-family-protein
MFNVRFHGRGGQGVVTAAEMLSAAAFDMGLHGQAFPTFGSERTGAPVVSFCRIHDRPIGFHEPISVPDALVVQDPTLLHVLAVLEGASPVTYLLVNTSRSFADVGLEGYVDWLAPGRAATLPATEMAREFLGRPMPNTALLGAFAALTGVVTLEAVTTAIRHRFGGVLPPDIVEANVEVATRAHGVICHV
>NC_008699.1|WP_011755807.1|2516219_2517425_-|2-ketoisovalerate-ferredoxin-oxidoreductase-subunit-alpha
MFEQLEGSRAVATAVARCRPAVIAAYPISPQTHIVEALSDFVRTGELRGCEYLMVESEFGAMSACIGASGVGARTYTATASQGLLFMAEALFNASGLGLPIVMTVANRAIGSPINIWNDQSDSMSQRDAGWVQLFAVSNQEAVDLHLQAFVLAERLSLPVMVCMDGFVLTHAVEAIDVPEQAQVDAFLPPFVPRQHLDPSDPITIGSMVGPEAFTEVRYLMHDQQLAALDELPRIQRDFHAEFGRDTGGLVRPYRTEDADVVVVALGSVLGGVNEVVDALREDGIAAGSLGITCFRPWPLDAVREALGSARQVVVVERAFSPGVGGIVGRDVRLALRGTVGGGPAVYDVVAGLGGRPVTRGSLRRLVDDVLAERLDPRGLHFLDLDHDLLARAGTPWRRTS
>NC_008699.1|WP_041546537.1|2515218_2516238_-|pyruvate-ferredoxin-oxidoreductase
MEEDVVTDLKLYQVGTFAAGNRLVDLELRSVQAHPDRTNSITSGHRACQGCGEALGARYVLDAAMRAAGGDLVVANATGCLEVFSTPYPESSWQVAWLHSLFGNAPAVAAGMAAGLRALGRETRVVGQGGDGGTVDIGFGCLSGMFERNDDVLYVCYDNQGYMNTGVQRSGATPPAARTANTAPVGPEPGNAFGQGKSAPLIAMAHEIPYVATATVADLRDLERKVEKAMSIRGARYLHVLVPCPLGWAAAPSDTIRLARLATESGIFPVFEAEHGEVTDVSPIRRQVPVEEYLKLQGRYAHLFGKHARPDLVARLQAGADRNIARFGLLEAEPRTGSD
>NC_008699.1|WP_041546538.1|2525400_2525586_-|hypothetical-protein
MPGPREICSHCGHLIVDVPQVGWVAPELGDSYDLCAGDTFGNHLPRRESTRTKSALARSGI
>NC_008699.1|WP_011755816.1|2525865_2527872_+|threonine--tRNA-ligase
MSDLKIALTHADAREERTVTTGTKAWELFQDDPSVIAARVNGALRDLAHELADGDQVEPVAIDSPDGHDILRHSTAHVMAQAVQQLFPDAKLGIGPPVENGFYYDFDVDTPFNPADLDKIETAMRKIIKEGQRFSRRVTTDADAISELRDEPYKIELIGLKGSGASTGSTTEAVEGASVEVGAGELTIYDNIRRNGDVAWSDLCRGPHLPTTKRIPAFKLMRTAAAYWRGNEKNKQLQRIYGTAWESKDALEEHLHRIEEAERRDHRKLGRDLDLFSFPDEIGSGLPVFHPKGGVIKRVMEDYVRQRHVEEGFEYVGTPHIAKEGLFYTSGHLPYYGEAMFPPLDVDGMDYRLKAMNCPMHNLIFRSRQRSYRELPLRLFEFGHVYRHEKSGVIHGLTRVRGFAQDDSHSYVTKEQAPAEIKHLLDFCLGLFRDFGLDDFYLELSTRDDSKPDKFIGSDEDWAVATKVLEDVCIASGLELVPDPGGAAYYGPKVSVQARDAIGRTWQMSTIQYDFNQPSADRFDLHYTAADGSRQQPVMIHSAKFGSIERFIGVLVEHYAGAFPPWLAPVQVQAIPIAERHNDYLYDVAKRMQAQGLRVEVDDSDDRMQKKIRNAQLLKVPFMMIAGDDDVAAGAVSFRYRDGRQDNGVPLDEAIRRVADAVASREQV
>NC_008699.1|WP_049774578.1|2527882_2528329_-|GNAT-family-N-acetyltransferase
MAVAADIWHRGWHLAHAGHVPEGLTAARTLAAFHERTPGRVADTTVAEVDGGLAGFIMIADDELEQLFVDPARHGSGVAAPLLAEAERQIAAAGHAEAWLAVVAGNARARRFYEKHGWRDGGDLPYEVTAGGTTYVSPCRRYVKSLRA
>NC_008699.1|WP_011755818.1|2528391_2528916_+|HIT-domain-containing-protein
MTDPAGHERDGFEGFDRLWTPHRMAYIVPSIPVDGDGCPFCAMEHMAPEDSLVVHRGETCFVVLNLHPYNPGHLMVLPHRHVAELEDLSVEEVTELMTTTQQAVRVLREIAGPHAFNIGVNLGGVAGGSLSQHLHQHVVPRWSGDANFITVLGGTKTLPQLLADTRRLLVEAWA
>NC_008699.1|WP_011755819.1|2528912_2529692_+|inositol-monophosphatase
MSPDPSLAEDAALAARLVRDAGTLAARMRAEGLEAATKTSISDVVTAADHAAERLVVDALAAERPRDGVLGEEGAASEGTSGRTWVIDPVDGTYNFVAGLDWWCSALALTDGDDLVLGAVHHPASGRTFVGGPGLPTTVDGVALPALDDRRLAAACLTTYLHPPSYGAEVGAAFTRLVGGAATLRMLGSASMDATAIASGQLHVRCQHSLPPWDDLPGAALILGVGGATAHVDAAGVRWSAAGAPRAVADVCAALEATG
>NC_008699.1|WP_011755820.1|2529784_2530405_+|antibiotic-biosynthesis-monooxygenase
MHARSITFMGDPSRLAAGIDYVRDDVMPMLDAIEGCLGMSMLADPETGQVIVTSSWRSAEDLDASDRLLTGSRARAAEIMGAPPEAAVWEVAVMHRDHRAAAGSCCRVTWLRLNHTDVGRGVELYRTALLPAMAELPGFCSASLLVDRRAGRACSTTTYDSRAAMESSRDRSWAIRDAGVRESGVDVMDVAEFDLVLAHLHLPELV
>NC_008699.1|WP_011755821.1|2530429_2531593_-|xylose-isomerase
MTESSFSPTRDDHFTFGLWTVGWQGVDVFGTAIRPVLEPAEAIHRLSDLGAYGVTFHDNDVFPFDADATTKEQHLAPFRKALEETGLVVPMVTTNLFSHPVFRDGGFTNNHRDVRRFAIRKAADQIDLAAELGAKIFVAWGGREGAESGAAKDIKSALSRYKEAFDLLGAYVLEQGYDLRFAIEPKPNEPRGDILLPTVGHALAFINELEHPELVGLNPEVGHEEMASLNYAHGLAQALWHGKLFHIDLNGQHGPRYDQDLRFGAGNARGAFWTVDIVENGGYEGPRHFDYKPPRTEDMDGVWVSAEACMRNYLILREKVRAFRADPEVQQALKDARVDQLAVPTVAAGESLADLRAEAFDPDQAAQRGMGFEKLDQLALEHLYGVR
>NC_008699.1|WP_011755822.1|2532003_2533134_+|substrate-binding-domain-containing-protein
MVRIQGARLASLVAVGALAFGSLAACGSDSDGGDTGSESTNGTSESSAPEVTGKVGVILPDSKTSVRWETQDRPNLEAAFKAAGLESIIQNAEGSPDTFGQLCDQMITEGVQVLIETDLDPDSGKACIDKAKNAGIAVIDYDRLTLGGGADYYVSFDNVKVGALQGQGLIDALQAKGEKSGNIAFINGAATDNNATLFKQGYEQVIKDDGSYTVVGDQTGEWDPDTAGKVFDQFYAAHPDLVGLVTANDGMAGGVIAREKAAGVEGKILVTGQDATAEGLANVLLGYQAGTVFKDTSIEAKAAADLAIAIIKGEDPSTIATGSVNDSVLGVDVPSVLATPVWITADTVKDVVAAGQANAADICKGIEDLCKKYGVA
>NC_008699.1|WP_011755823.1|2533225_2533984_+|sugar-ABC-transporter-ATP-binding-protein
MSSGEPLLELRGVQKSFGAVHVLQGVDLTVRPGRVTALVGDNGAGKSTLIKGIAGIHPFDEGDYAFEGNPVHVKNPRDSNALGIEVVYQDLALCDNLDVVHNMFLGRELTKGGMVDEDTMEARARETLDGLSVRTLQSVRTHVAALSGGQRQTVAIARAVLWNSKIVILDEPTAALGVAQTEQVLKLVRRLADRGLGVVLISHNLNEVFQVADDIAVLYLGQMVGQVDVATTSRERVIAAITTGKVNEGDAA
>NC_008699.1|WP_011755824.1|2533980_2535240_+|ABC-transporter-permease
MSVATEEIHDRQDTHSRATVGGLVKEYLAKLRGGDVGSLPAILGLVALVIVFSSLRPETFTKAFNFGNLIQQSAGVTIIAMGMVFVLLLGEIDLSAGYTGGTAAAVMSLLLTEQGWPTPLAILACLATGMVIGTGIGLIVAWLGIPSFVVTLAMFLGLQGVMLSIIGEKGSIDSGEFVAKLNSETISVWLGWVIAVALVGLYATSTFLSNRRRRRHGLTSQPTLLWALKSGGLAVITILVVFYLSIERSPNAHIKSIKGVPISLLILIGLALVLGALLSRTKWGSHVYAVGGNAEAARRAGINVAMIKLSCFVLGSTVAAVGGIMLASYSGGVNNVTGGSTILLYAVGAAVIGGTSLFGGKGRVIDALIGGTVVAVIANGMGLLNQPDSRKYIVTGLVLLVAASVDAISRRRATATGRA

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Crispr_ID: NC_008699_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_23

2576469-2576553

Orphan

Consensus_repeat	Method
TCCCCGGTGAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_23

>merge|NC_008699|23|2576469-2576553|CRISPRCasFinder
TCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAACATCCCCGGTGAACCGGGGAAACCG

>NC_008699|23|23|2576469-2576553|CRISPRCasFinder
TCCCCGGTGAACCGGGGAAACCG	GAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAACA
TCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011755857.1\|2571514_2572243_+\|prepilin-peptidase	unknown	unknown	gnl\|CDD\|224900
NC_008699.1\|WP_011755862.1\|2575652_2576450_+\|SIMPL-domain-containing-protein	unknown	unknown	gnl\|CDD\|225516
NC_008699.1\|WP_011755869.1\|2582617_2584087_+\|arginine-ornithine-antiporter	unknown	unknown	gnl\|CDD\|163522
NC_008699.1\|WP_011755865.1\|2577701_2579078_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224169
NC_008699.1\|WP_041547613.1\|2573499_2574009_+\|shikimate-kinase	unknown	unknown	gnl\|CDD\|234654
NC_008699.1\|WP_011755855.1\|2569477_2570671_+\|endolytic-transglycosylase-MltG	unknown	unknown	gnl\|CDD\|376862
NC_008699.1\|WP_011755856.1\|2570705_2571518_+\|shikimate-dehydrogenase	unknown	unknown	gnl\|CDD\|234703
NC_008699.1\|WP_011755866.1\|2579074_2579911_+\|DUF1206-domain-containing-protein	unknown	unknown	gnl\|CDD\|377695
NC_008699.1\|WP_011755870.1\|2584228_2585524_+\|arginine-deiminase	unknown	unknown	gnl\|CDD\|234949
NC_008699.1\|WP_011755863.1\|2576694_2577258_+\|elongation-factor-P	unknown	unknown	gnl\|CDD\|234788
NC_008699.1\|WP_011755858.1\|2572282_2573461_+\|chorismate-synthase	unknown	unknown	gnl\|CDD\|235438
NC_008699.1\|WP_011755860.1\|2574005_2575103_+\|3-dehydroquinate-synthase	unknown	unknown	gnl\|CDD\|234565
NC_008699.1\|WP_011755871.1\|2585552_2586557_+\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|179366
NC_008699.1\|WP_011755867.1\|2580026_2581346_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223531
NC_008699.1\|WP_011755864.1\|2577257_2577665_+\|transcription-antitermination-factor-NusB	unknown	unknown	gnl\|CDD\|234686
NC_008699.1\|WP_011755854.1\|2569006_2569477_+\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|335420
NC_008699.1\|WP_011755861.1\|2575099_2575540_+\|3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|238262
NC_008699.1\|WP_011755853.1\|2566292_2568983_+\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NC_008699.1\|WP_011755868.1\|2581357_2582389_+\|NADPH:quinone-reductase	unknown	unknown	gnl\|CDD\|176215
NC_008699.1\|WP_011755872.1\|2586571_2587528_+\|carbamate-kinase	unknown	unknown	gnl\|CDD\|183466

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011755857.1\|2571514_2572243_+\|prepilin-peptidase	gnl\|CDD\|224900	COG1989, PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	6.64803e-08
NC_008699.1\|WP_011755862.1\|2575652_2576450_+\|SIMPL-domain-containing-protein	gnl\|CDD\|225516	COG2968, COG2968, Uncharacterized conserved protein [Function unknown].	1.08409e-39
NC_008699.1\|WP_011755869.1\|2582617_2584087_+\|arginine-ornithine-antiporter	gnl\|CDD\|163522	TIGR03810, arginine-ornithine_antiporter, arginine-ornithine antiporter. Members of this protein family are the arginine/ornithine antiporter, ArcD. This exchanger of ornithine for arginine occurs in a system with arginine deiminase, ornithine carbamoyltransferase, and carbamate kinase, with together turn arginine to ornithine with the generation of ATP and release of CO2. [Transport and binding proteins, Amino acids, peptides and amines].	0
NC_008699.1\|WP_011755865.1\|2577701_2579078_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224169	COG1249, Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion].	1.32629e-122
NC_008699.1\|WP_041547613.1\|2573499_2574009_+\|shikimate-kinase	gnl\|CDD\|234654	PRK00131, aroK, shikimate kinase; Reviewed.	1.3282e-60
NC_008699.1\|WP_011755855.1\|2569477_2570671_+\|endolytic-transglycosylase-MltG	gnl\|CDD\|376862	pfam02618, YceG, YceG-like family. This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 389 amino acids in length. This family was previously incorrectly annotated and names as aminodeoxychorismate lyase. The structure of YceG was solved by X-ray crystallography.	1.11059e-87
NC_008699.1\|WP_011755856.1\|2570705_2571518_+\|shikimate-dehydrogenase	gnl\|CDD\|234703	PRK00258, aroE, shikimate 5-dehydrogenase; Reviewed.	2.12728e-72
NC_008699.1\|WP_011755866.1\|2579074_2579911_+\|DUF1206-domain-containing-protein	gnl\|CDD\|377695	pfam06724, DUF1206, Domain of Unknown Function (DUF1206). This region consists of two a pair of transmembrane helices and occurs three times in each of the family member proteins.	3.16883e-13
NC_008699.1\|WP_011755870.1\|2584228_2585524_+\|arginine-deiminase	gnl\|CDD\|234949	PRK01388, PRK01388, arginine deiminase; Provisional.	0
NC_008699.1\|WP_011755863.1\|2576694_2577258_+\|elongation-factor-P	gnl\|CDD\|234788	PRK00529, PRK00529, elongation factor P; Validated.	7.73764e-110
NC_008699.1\|WP_011755858.1\|2572282_2573461_+\|chorismate-synthase	gnl\|CDD\|235438	PRK05382, PRK05382, chorismate synthase; Validated.	1.39931e-179
NC_008699.1\|WP_011755860.1\|2574005_2575103_+\|3-dehydroquinate-synthase	gnl\|CDD\|234565	PRK00002, aroB, 3-dehydroquinate synthase; Reviewed.	2.65863e-156
NC_008699.1\|WP_011755871.1\|2585552_2586557_+\|ornithine-carbamoyltransferase	gnl\|CDD\|179366	PRK02102, PRK02102, ornithine carbamoyltransferase; Validated.	0
NC_008699.1\|WP_011755867.1\|2580026_2581346_+\|hypothetical-protein	gnl\|CDD\|223531	COG0455, flhG, Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility].	4.12114e-09
NC_008699.1\|WP_011755864.1\|2577257_2577665_+\|transcription-antitermination-factor-NusB	gnl\|CDD\|234686	PRK00202, nusB, transcription antitermination factor NusB.	4.45273e-48
NC_008699.1\|WP_011755854.1\|2569006_2569477_+\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|335420	pfam03652, RuvX, Holliday junction resolvase. This family of nucleases resolves the Holliday junction intermediates in genetic recombination.	2.25229e-48
NC_008699.1\|WP_011755861.1\|2575099_2575540_+\|3-dehydroquinate-dehydratase	gnl\|CDD\|238262	cd00466, DHQase_II, Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway and the catabolic quinate pathway. There are two types of DHQases, which are distinct from each other in amino acid sequence and three-dimensional structure. Type I enzymes usually catalyze the biosynthetic reaction using a syn elimination mechanism. In contrast, type II enzymes, found in the quinate pathway of fungi and in the shikimate pathway of many bacteria, are dodecameric enzymes that employ an anti elimination reaction mechanism.	3.50929e-78
NC_008699.1\|WP_011755853.1\|2566292_2568983_+\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NC_008699.1\|WP_011755868.1\|2581357_2582389_+\|NADPH:quinone-reductase	gnl\|CDD\|176215	cd08253, zeta_crystallin, Zeta-crystallin with NADP-dependent quinone reductase activity (QOR). Zeta-crystallin is a eye lens protein with NADP-dependent quinone reductase activity (QOR). It has been cited as a structural component in mammalian eyes, but also has homology to quinone reductases in unrelated species. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	4.49593e-124
NC_008699.1\|WP_011755872.1\|2586571_2587528_+\|carbamate-kinase	gnl\|CDD\|183466	PRK12354, PRK12354, carbamate kinase; Reviewed.	0

>NC_008699.1|WP_011755862.1|2575652_2576450_+|SIMPL-domain-containing-protein
MNANVTVSVRGLLVAALVAMALVVAYLLGGSGGGTPAAQAADDGGTSAPAERPRLLTMTGTGEAGAVPDQLSFGLRVTLTRVDLDEALAAANASMSRVLRALDEYDVARSDVQTTGLSMTPVYAYHDYSPPTITGYRVSERASVLVKELAQGGKAVSAAVAAGGNAVRVGDIRLLVGDSDAVLEKARDAAVQEATAKAQQYAEASGQTLGDVVTLREVHARPLPSPYLQFGSAVAGRAAMDLSAVPIRAGRDKSAVTVRVVWELS
>NC_008699.1|WP_011755861.1|2575099_2575540_+|3-dehydroquinate-dehydratase
MSHGRRVLVLNGPNLGRLGRRQPEIYGTTTHAELADLCVAWGRDLGLDVEVRQTNHEGELLDWLNAAADDAEPVVLNAAAWTHYSYALLDACAQLVAPLVEVHISDPRQRPEEFRHTSVVTPYAVEVFAGHGIEGYRLALEAVARR
>NC_008699.1|WP_011755860.1|2574005_2575103_+|3-dehydroquinate-synthase
MRDTVVRVTGAAPYDVVIGHDLSERLPQLLGVGVQRVAVVFSDALAELVNPVLDSLAAAYDVMVLPIPDGERAKKAAVAVSCWEALGEAGFTRSDAVVTFGGGATTDVGGFVAATWLRGVKVVHVPTTLLGMVDAAVGGKTGVNTRSGKNLVGAFHEPAGVLCDLSTLRSLPRAELLAGLGEVIKCGFIADPAILNLVEGNEASRLDADSLVLRELVERAVRVKAGVVSADLKETGGRPDDPGREILNYGHTMAHAIERTENYRIRHGEAVSIGCVYVAELANRAGTLASDIVERHRHAFARVGLPTSYSKASFDDLHRAMRVDKKARGSQLRFIVLSDLAVPTVLAGPSVVDLRDAYAAIGGPA
>NC_008699.1|WP_041547613.1|2573499_2574009_+|shikimate-kinase
MGAGKTTVARLLADAWGTGVRDTDHDVESAEGRTISDIFVDSGEGAFRDLERRAVAAALREHDGVLALGGGAVLDPGTRDLLAGHRVVFLRVGLSDAVKRVGLGVARPLLLGNVRGRIKALLDERTPIYESVATLVVDTDGRSPEDVAQEIRAALDGPALDGSALEGEA
>NC_008699.1|WP_011755858.1|2572282_2573461_+|chorismate-synthase
MLRWLTAGESHGPSLVAILEGLPAHVQVTSDDVADALARRRLGYGRGARMKFERDEVTLVGGIRHGETMGGPVAIEIGNTEWPKWEKVMAADPVDPVELESLARNAPLTRPRPGHADLVGMQKYDFTEARPILERASARETAARVALGRVASNLLEQAVGARIVSHVIELGGVRAPAGLWPQPEDVDRLDDDPVRCLDADTSKLMVEAIDQAHQDGDTLGGVVEVVVHGLPPGLGSHVHWDRRLDARLAGALMGIQAIKGVEVGDGFELAATPGSRAHDEIVSGTDGLRRVSGRSGGTEGGMSTGEVLRVRAAMKPIATVPRALRTVDVATGEAAVAHHQRSDVCAVPAAGIVAEAMVALVLADAVLEKFGGDSVRETRRNAEGYLDTLRFR
>NC_008699.1|WP_011755857.1|2571514_2572243_+|prepilin-peptidase
MSVDPGAVVLGAAACGAAGLLVPALIARIPEPDADPEHDVVTEDPGAPSYAEVAAAPGLRSVAAVLSLVAGGLVGAGVGLDWPLLFLLPLVPVGVALAVVDLRTRLLPTVVVWPTLAATAVLAVLSGLLDDDQDALVRAGLGGVVVFALFFALWWIHPAGMGYGDVRLSAVLGLALGYLGWAELAIGIYGGFLAFSVPGLLLALLRRDRAILRAAYPFGPFLLAGALAGVVLGPLWTGLASG
>NC_008699.1|WP_011755856.1|2570705_2571518_+|shikimate-dehydrogenase
MTRCAVLGDPIAHSLSPVLHRAGYAALGLDWSYEAVRVPEDGLEGFLTGLGPQWRGLSLTMPLKRRALAIVAGVTERARLAGGVNTLVLEDGAVVLADNTDLPGAVAAVRERYAGPVTAGTVLGGGATAAATGLALVELGARRVRLLARTPERAAAAAGAIAAHPAAPQVEVATLADGPVDGEIVVSTIPAAAQDPSLVARCGAVPVVFEVVYDPWPTPLAASATGRILVGGLDLLVHQAVLQFELFTGAPGPLDAMRAAGERALGTAPA
>NC_008699.1|WP_011755855.1|2569477_2570671_+|endolytic-transglycosylase-MltG
MTDEHDAEYDDPRDDAGLLGVQEPAYEAGRRRGRKRRSLPGCLAVLLALAIIVGGFYVVVTWGIDKVRDQFDSAEDYPGPGRGNVTYQVVSGATAGSIGRDLKAAGVVASVDAFVQAANASPDWADLQAGYFALKKQMAAADAVEILVDPANMVKDTVTIPEGLRVVDIVGILAKKTDYPKADFEKVLDNPGDLGLPSYAEGNPEGYLFPATYDFGPDATPESMLTAMVTRWKQAAEDADLEAAAAELGYTPAELMTVASLVQAEGRGDDMPKIARVIYNRVENPDNGVTNGLLQVDASVNYALERSTIAVLTQAEIDSVADSPYNTYTQTGLPPAPIEAPGDDAIEAAAHPADGDWLFYVTVNLRTGETKFTEDYQEFLGFKQELQEYCDTQSDRC
>NC_008699.1|WP_011755854.1|2569006_2569477_+|Holliday-junction-resolvase-RuvX
MRAGVRIGIDPGDARIGVARSDPSGFLATPVETVRRGKGDLARIGRILAAEEDEGATVLEVVVGLPRSLSGREGPAAAKVREFAGRLAARVAPVPVRLVDERMTTVSAEAMLRDQGRTGGKRRAVVDQAAAVLILQHALDTERATGAAPGEIVEET
>NC_008699.1|WP_011755853.1|2566292_2568983_+|alanine--tRNA-ligase
MDTAEIRRRFVAHFEHNTTVGAHTPVPSASLLLDDPNLLFVNAGMVPFKPYFLGQEAPPYPRATSVQKCVRTPDIEDVGKTTRHGTFFEMCGNFSFGDYFKEGAIELAWDLVTRPLADGGWGLEESKLYPSVYEDDPEAVALWKKVTGLPEERIIRLGKRENYWSMGVPGPGGPCSEILYDRGPDYGPDGDFGPKGEDRYLEIWNLVFMQDELSAVRSKEDFDIAGSLPKKNIDTGMGLERVAFLLQGKANMYEIDVMFPVIQKAEELTGRRYGADHDDDVRFRVVADHVRSSMMLIGDGVTPGNEARGYVLRRLLRRAVRSMRLLGYEDPALPELFPISRDKMGETYTALHRDWERISTVAYAEEHAFRQTLRSGTTIFDQATAELKQAGGSQLSGDKAFALHDTYGFPIDLTLEMAAEQGLAVDEVGFRRLMNEQRQRAKDDAKAKKGQHRDASAYRQVADSLGRPVEFTGYDVVTDEASVRGLVAAGGVVSSAGPGDDVEIILDRTPFYAEGGGQLADQGVIELDNGARVEVRDVQSPVRGLIVHHATVLSGEVSIGLGAHALVDVERRRSISRSHTATHMVHKAFREALGETATQAGSENSPGRFRFDFSAVGAVPESVMADVEARVNEVVLDDLAVHAEVMSQADAVKSGAMALFGEKYGDRVRVVSVGDWARELCGGTHAGSSGKLGVVKLLGESSIGSGVRRVEALVGSDAYRFLAREHVLVAQLSDTLKVRPEQLPERVHDLVEKLREAEKEIERVRVGQLLAAAGELAAGAAKVGPVNLVAHRADGAGGGDVRTLALDVRGRLPQGEPGVVVVIGAVDGKVAVVAALNDEARARGLSANELVRAVGPLVGGKGGGKDDVAQGGGTDASRIDEAITLVTAEVGRVAAG
>NC_008699.1|WP_011755863.1|2576694_2577258_+|elongation-factor-P
MATTNDLKNGMVLNIDGQLWAVVEFQHVKPGKGPAFVRTKLKNVESNKTVDKTFNAGTKVETATVDRRTMQYLYNDGSSYVFMDVQSYDQLEIAPEIVGNAKNFLLENQEAIVATNEGRVLFIELPASVELEITFTEPGLAGDSATGRTKPATLETGHEIQVPLFINQGEKVKVDTRDSSYLGRVKG
>NC_008699.1|WP_011755864.1|2577257_2577665_+|transcription-antitermination-factor-NusB
MSARSKARKRALDVLFASDVRGEDAVAALDRAIAEGEGPTNDYTATLVRGVVEHQARIDELLSSYSHGWALDRMPAVDRNVLRLGVWELLYADDVPDAVAVSEAMALVTDLSTDESPQFVNGILGSIVRNKPSLA
>NC_008699.1|WP_011755865.1|2577701_2579078_+|NAD(P)/FAD-dependent-oxidoreductase
MDAHEVDLVVIGTGPGGEALATGAARAGLRVVAVDRHLVGGECPYYGCIPTKMMVRGSDAVAEVRRAAGVAGEATIAPAWSVVARRIDEEATTGWDDTIAVDRLRDAGVTFHHGAGRLDGPGRVRVEEPDGTATTYAATRGVLVNPGTRPAVPPVDGLADAPYWTNREAVRVTELPGSLVVLGGGPIGCELAQVFSRFGVRVAVVQRGPRLLPADEPEAAELVAEVFAEEGIRVLTGAEATRVAYDEGGFTIRLDTGEQLSADKLLVAAGRTPNLDDLGLDTVGLDPTARTLEVDERLRAGDRLWAIGDVTGRGAFTHVSMYQSAIALRDILGEPGAPARYHAVPHTTFTDPEVGGVGLTESRARESGLRVRTGGTDLAGSSRGFTHGPGGHGLIKVVEDADRGVLVGATAVGPAGGEILGFLAVAVHAEVPVETLRNMMYAYPTFHRAIESAIADLS
>NC_008699.1|WP_011755866.1|2579074_2579911_+|DUF1206-domain-containing-protein
MTVSGGSTARRAEGAAREAQHSEWVDHAVRAGLVAYAVVYLMIGWLAVQLAFGDRSGKPSSSGAMHELAQQPFGDVLIWVVSLGMFLLVAWKLLDAGFGHRDEQDSGKRTRARLTSAAKAIVYAAIGVSGLRVATGSGSSGKGQKSWTAELMDVTGGQLLVGLIGLAIMGYGGYQVYKAWTEGFADKLDAEGRSGSTGTAYLAFGKAGYTARGIAFLIVGGLVLYGAITHDASKSGGLDQALFKVLDQPFGPVLLCLLGVGLACYGIFTLARARHLSR
>NC_008699.1|WP_011755867.1|2580026_2581346_+|hypothetical-protein
MSQDAWSSAGSRHDHDATSDRLYTPEDLAGYAARRDARAGAGSRGPSAGPTDPLTDPLTAPLADPGLEPPVGTAPTRVPASPPPSGPPPSYRPAGPPPSAPPSVPVVLVAEGEPLDPEQPADAGELRRFMTATDFLDRRDAAQEHGPATWGWRGAVRRWSGGLVTPRMGPAEQAYERDRQAIQKDFDGPRTIAFINPKGGAAKTTGVLAAGYTFGTVRGGGVVAWDNNETRGTLGIRGTRSAHRNTTRELLEDLERFTDVYQSRIGDLGAFVRSQGDAHFDVLASDERPDVTGTIRAQDFDAVHKLLERFYRIILVDTGNNMRAENWLAAAGAADLLVVTSTVREDTGYSGLWMLDALQDAGYQNLKYKAITVLSDPSATVDTKLAADLVDVYQQRTREVYRVPYDPALVAGSVVPYSQLSRGTKREWLKACAGMAAAL
>NC_008699.1|WP_011755868.1|2581357_2582389_+|NADPH:quinone-reductase
MRAVVYQQTGPSSVLEVVERDLPVPGPGEVRVRVVRAGVNPTDWKFRAGMMTEYDEVVPGQDGAGVVDAVGEGVDGLAVGDRVWLVLAQAGRAYGTAAELTVQPAARVVPLPADASFDLGASLGVPAVTAHRALTAAEGGPSRLWPGALEGRVVLVAGGAGAVGNAAIQLARWAGATVVTTVSSAEKAALARAAGADHVVNYREPGAAQAILETAPDGVDLAVEVAPAQNIELDLDVVRVHGTVSIYANNGGDTLTMPLRAAFGKNLRFQFLILYTLREDLLRAAVEDISVALAAGALRVGEEAGLPLHHYPLAQAAEAHDAVEGGVVGKVLLDVGSAADRDL
>NC_008699.1|WP_011755869.1|2582617_2584087_+|arginine-ornithine-antiporter
MTQQMVRPPSGPSPEQSARGAGTLALPALIALVVGSMIGSGIFALPSQMAGSAAPGPLLIGWLVTGVGMLMLAFVFQTLSRRKPDVDGGVYGYARAGFGNYLGFTSAWGYWISAWIGNVGYLVLLMSTLGYFVPAFEGGNTVAAIIGASVVLWVVQALTLRGVQSAAFVNTLVTIAKIVPLLTFIAIAAVGFKAGIFTADVWGDSAGLGSTLDQVKNMMLVTVWVFIGIEGAAVYSQRATRRSDVGRATVIGFVGVLALLLAVNVLSYGLMSQAKLAGLEDPSMAGLMRQEVGAWGTGFISIGLAVSVAGALLAWVLLSVEILRLPAREGVLPRQLGTENRYGAPSVALWLTSGCVQLMLLWTLVNENTYTDLIYLATSLILLPYLWSALYQVKLAISGESYAQGESRTRDLLVGLVALAYAVWLVYAGGWEYVLVAGIFYLVGTALYVWARSQARAAIFTVAERAVVAVVVGLSIAGVIGLVQGFVSI
>NC_008699.1|WP_011755870.1|2584228_2585524_+|arginine-deiminase
MAIEQLPRAAVEETVAEPRVGVWSEVGRLRRVMVCAPGLAHLRLTPDTCDELLYDDVIWVGQAKRDHYDFVMKMRDRGVEVLDMLQLLVDVVRYPEGRNWILDRKVTDDQVGPGLVHEVRAWLESLPAEKLAEFLIGGVAFGDVPDDMAGPFLRAFRDAEVQQFVLPPLPNTTFARDNSSWVYQGVTLNRMYWGARRQETLLTTAIYRFHPSFAGEDFRVWFGDPDQQPRDRGNATIEGGDVMPIGNGAVVIGMGERTSQQAITQVARSLFAAGAADRVIAAGLPRMRAAMHIDTVFTFCDRDVVTAYGPVVDAINSFSLRPDDSSPSGLDIRHEGKHFVDVVSDALGTPMRVVPTGGDRYGSAREQWDDGNNVLAIEPGVVVGYDRNTHTNTQLRKAGIEVITIDASELGRGRGGGRCMTCPILRDPVDY
>NC_008699.1|WP_011755871.1|2585552_2586557_+|ornithine-carbamoyltransferase
MPVNLRGRHLLSLRHHSADEIRYLLDLSRDLKRAKYAGSERQLLQGRNVALIFEKTSTRTRCAFEVASYDQGAHVTYIDPASSQLGHKESVKDTARVLGRMYDAIEYRGFSQQVVEELAEYAGVPVFNGLTDEFHPTQMLADVLTMREHCDKPLHEIAFAFMGDGRNNVANSLLLVAAKLGMDVRIGAPKELWPEDELVKLCHDLADVSGARITITDDPTQAVAGVDFIYTDVWVSMGEPVESWAERVERCLPFQVNADLLHATGNARVKVLHCLPAFHNTETKVGHQVVAQYPQLANGIEVTEDVFESAANISFDQAENRMHTIKALLVASLA
>NC_008699.1|WP_011755872.1|2586571_2587528_+|carbamate-kinase
MRIVIALGGNALLRRGEPLTADNQRANIRIAAERIATVVPDNEVVIAHGNGPQVGLLALQAAAYEDVRPYPLDVLGAQTEAMIGYVIEQELGNVLPEEQHIATLLTMVRVDPEDPAFQNPTKFIGPVYMQDEAEELAAENGWVIKQDGSAFRRVVASPEPQHIYEVPSIRSLVEDGTVVICAGGGGIPTVLEPGRILRGVEAVIDKDLASSLLAQEIGADLLVIATDVDGVYLDWGSPDQRLLTETTPQELRAFDFAAGSMGPKVEAVCRFVEQTGRSAAIGSLADIAEIVAGRAGTRVVPDGHGPASGQDRELVVSG

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Crispr_ID: NC_008699_24

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_24

2592707-2592808

Orphan

Consensus_repeat	Method
CCACAGTGGGGGGCTTCGCCCCCCACACCCCCCGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_24

>merge|NC_008699|24|2592707-2592808|CRISPRCasFinder
CCACAGTGGGGGGCTTCGCCCCCCACACCCCCCGCGCCCCCCACACCCCCACAGTGGGGGGCTCCGCCACAGTGGGGGGCTCCGCCCCCCACACCCCCCGCG

>NC_008699|24|24|2592707-2592808|CRISPRCasFinder
CCACAGTGGGGGGCTTCGCCCCCCACACCCCCCGCG	CCCCCCACACCCCCACAGTGGGGGGCTCCG
CCACAGTGGGGGGCTCCGCCCCCCACACCCCCCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011755871.1\|2585552_2586557_+\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|179366
NC_008699.1\|WP_011755886.1\|2601487_2603521_+\|primosomal-protein-N'	unknown	unknown	gnl\|CDD\|237844
NC_008699.1\|WP_011755884.1\|2598780_2600091_+\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	unknown	unknown	gnl\|CDD\|235513
NC_008699.1\|WP_011755882.1\|2597879_2598464_+\|guanylate-kinase	unknown	unknown	gnl\|CDD\|234719
NC_008699.1\|WP_011755878.1\|2595121_2596189_+\|quinone-dependent-dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235388
NC_008699.1\|WP_011755867.1\|2580026_2581346_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223531
NC_008699.1\|WP_011755885.1\|2600172_2601363_+\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NC_008699.1\|WP_011755873.1\|2587675_2588290_+\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	unknown	unknown	gnl\|CDD\|235365
NC_008699.1\|WP_011755869.1\|2582617_2584087_+\|arginine-ornithine-antiporter	unknown	unknown	gnl\|CDD\|163522
NC_008699.1\|WP_011755870.1\|2584228_2585524_+\|arginine-deiminase	unknown	unknown	gnl\|CDD\|234949
NC_008699.1\|WP_011755883.1\|2598473_2598806_+\|DNA-directed-RNA-polymerase-subunit-omega	unknown	unknown	gnl\|CDD\|234744
NC_008699.1\|WP_011755876.1\|2590552_2591689_+\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237139
NC_008699.1\|WP_011755880.1\|2597003_2597435_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011755872.1\|2586571_2587528_+\|carbamate-kinase	unknown	unknown	gnl\|CDD\|183466
NC_008699.1\|WP_011755875.1\|2589257_2590556_+\|dihydroorotase	unknown	unknown	gnl\|CDD\|236479
NC_008699.1\|WP_011755868.1\|2581357_2582389_+\|NADPH:quinone-reductase	unknown	unknown	gnl\|CDD\|176215
NC_008699.1\|WP_011755874.1\|2588286_2589261_+\|aspartate-carbamoyltransferase-catalytic-subunit	unknown	unknown	gnl\|CDD\|234849
NC_008699.1\|WP_011755879.1\|2596185_2597007_+\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|234651
NC_008699.1\|WP_011755887.1\|2603596_2604142_+\|peptide-deformylase	unknown	unknown	gnl\|CDD\|234668
NC_008699.1\|WP_041547624.1\|2597543_2597864_+\|30S-ribosomal-protein-S13	unknown	unknown	gnl\|CDD\|223177

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011755871.1\|2585552_2586557_+\|ornithine-carbamoyltransferase	gnl\|CDD\|179366	PRK02102, PRK02102, ornithine carbamoyltransferase; Validated.	0
NC_008699.1\|WP_011755884.1\|2598780_2600091_+\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	gnl\|CDD\|235513	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated.	0
NC_008699.1\|WP_011755882.1\|2597879_2598464_+\|guanylate-kinase	gnl\|CDD\|234719	PRK00300, gmk, guanylate kinase; Provisional.	4.59595e-98
NC_008699.1\|WP_011755878.1\|2595121_2596189_+\|quinone-dependent-dihydroorotate-dehydrogenase	gnl\|CDD\|235388	PRK05286, PRK05286, quinone-dependent dihydroorotate dehydrogenase.	1.2073e-165
NC_008699.1\|WP_011755867.1\|2580026_2581346_+\|hypothetical-protein	gnl\|CDD\|223531	COG0455, flhG, Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility].	4.12114e-09
NC_008699.1\|WP_011755885.1\|2600172_2601363_+\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NC_008699.1\|WP_011755873.1\|2587675_2588290_+\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	gnl\|CDD\|235365	PRK05205, PRK05205, bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR.	7.99695e-94
NC_008699.1\|WP_011755869.1\|2582617_2584087_+\|arginine-ornithine-antiporter	gnl\|CDD\|163522	TIGR03810, arginine-ornithine_antiporter, arginine-ornithine antiporter. Members of this protein family are the arginine/ornithine antiporter, ArcD. This exchanger of ornithine for arginine occurs in a system with arginine deiminase, ornithine carbamoyltransferase, and carbamate kinase, with together turn arginine to ornithine with the generation of ATP and release of CO2. [Transport and binding proteins, Amino acids, peptides and amines].	0
NC_008699.1\|WP_011755870.1\|2584228_2585524_+\|arginine-deiminase	gnl\|CDD\|234949	PRK01388, PRK01388, arginine deiminase; Provisional.	0
NC_008699.1\|WP_011755883.1\|2598473_2598806_+\|DNA-directed-RNA-polymerase-subunit-omega	gnl\|CDD\|234744	PRK00392, rpoZ, DNA-directed RNA polymerase subunit omega; Reviewed.	4.13157e-16
NC_008699.1\|WP_011755876.1\|2590552_2591689_+\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NC_008699.1\|WP_011755886.1\|2601487_2603521_+\|primosomal-protein-N'	gnl\|CDD\|237844	PRK14873, PRK14873, primosomal protein N'.	0
NC_008699.1\|WP_011755872.1\|2586571_2587528_+\|carbamate-kinase	gnl\|CDD\|183466	PRK12354, PRK12354, carbamate kinase; Reviewed.	0
NC_008699.1\|WP_011755875.1\|2589257_2590556_+\|dihydroorotase	gnl\|CDD\|236479	PRK09357, pyrC, dihydroorotase; Validated.	0
NC_008699.1\|WP_011755868.1\|2581357_2582389_+\|NADPH:quinone-reductase	gnl\|CDD\|176215	cd08253, zeta_crystallin, Zeta-crystallin with NADP-dependent quinone reductase activity (QOR). Zeta-crystallin is a eye lens protein with NADP-dependent quinone reductase activity (QOR). It has been cited as a structural component in mammalian eyes, but also has homology to quinone reductases in unrelated species. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	4.49593e-124
NC_008699.1\|WP_011755874.1\|2588286_2589261_+\|aspartate-carbamoyltransferase-catalytic-subunit	gnl\|CDD\|234849	PRK00856, pyrB, aspartate carbamoyltransferase catalytic subunit.	0
NC_008699.1\|WP_011755879.1\|2596185_2597007_+\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|234651	PRK00125, pyrF, orotidine 5'-phosphate decarboxylase; Reviewed.	2.37448e-105
NC_008699.1\|WP_011755887.1\|2603596_2604142_+\|peptide-deformylase	gnl\|CDD\|234668	PRK00150, def, peptide deformylase; Reviewed.	2.61279e-73
NC_008699.1\|WP_041547624.1\|2597543_2597864_+\|30S-ribosomal-protein-S13	gnl\|CDD\|223177	COG0099, RpsM, Ribosomal protein S13 [Translation, ribosomal structure and biogenesis].	0.000227095

>NC_008699.1|WP_011755876.1|2590552_2591689_+|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MTRAILVLEDGRSFQGESYGAEGETFGEAVFNTGMTGYQETLTDPSYHRQVVVMTAPHIGNTGVNDEDPESRRIWVAGYVVRDPARRSSSWRSRRTLDDELREQGVVGISDIDTRALTRHLRERGAMRVGISSTETDPAVLLERVRASEPMSGAELASEVSTQEAYVVPAIGERRYTVAALDLGIKSMTPHRMAERGIEVHVLPATASLADINAVSPDGLFYSNGPGDPAATTHQVDVLQGALAQGLPYFGICFGNQLFGRALGFGTYKLKYGHRGINQPVMDRTTGKVEVTAHNHGFAVDAPLSGSTTTPYGEASVSHVCLNDDVVEGLELRDGAGALRAFSVQYHPEAAAGPHDAAYLFDRFVDLMSGDHHSGEEA
>NC_008699.1|WP_011755875.1|2589257_2590556_+|dihydroorotase
MSTSYLIKNVSVLGGTPTDLLLEDGVIREAADRPDAEVIDATGLIALPGLVDLHTHLREPGREDAETVETGTHAAAMGGFTAVHAMANTEPVADTAGVVEQVWRLGREAGYCDVFPVGAVTVGLQGERLAELGAMADSAARVRVFSDDGKCVSDAVLMRRALEYVKAFDGVVAQHAQEPRLTEGAQMNEGELSGRLGLAGWPAVAEEAIIARDLLLAEHVGSRLHVCHVSTAGSVELIRWAKAKAEKDGHWEVTAEACPHHLLLTDELAATYDPIYKVNPPLRTAADAQALRAGLADGTIDIVATDHAPHPHEDKDCEWAAAAFGMLGLETALSVVQQTMVDTGLLDWAGLAERMSYAPARIGRVSDQHGRPVAIGEPANMVLYDPGATRTIDPSESASLSRNTPYRGMELPGRVVATFLRGRATVLDGKLQ
>NC_008699.1|WP_011755874.1|2588286_2589261_+|aspartate-carbamoyltransferase-catalytic-subunit
MKRHLLSAGDLSRDDAELVLRTAAELRELADRPIKKLPALRGRTVVNLFFEDSTRTRISFEAAAKRLSADVINFAAKGSSLSKGESLKDTALTLEAMGADAVVVRHGASGAPHRLAHSGWVRSSVVNAGDGTHEHPTQALLDAFTMWRHLGQGKEQSLDGRRIAIVGDVLHSRVARSNALLLKTLGAEVTLVAPPTLLPVGIDTWPVETSYDLDAVLPKADAVMMLRVQRERMSGGFFPTAREYSRRYGLDGRRMATLQDHTIVMHPGPMVRGMEITADVADSDRSVIVEQVTNGVAVRMAVLYLLLGGSEPAVSTSSTNEAEE
>NC_008699.1|WP_011755873.1|2587675_2588290_+|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR
MPAHPQAVPPGPSSSTDRAHPVRTVLDERDIGRALTRISHEILERNKGATDLVLLGIPSRGVPLAERIAERISTVEGYAVPVGSLDVTMYRDDLRMKPARTLLPTQIPAGGIDGRTVVLVDDVLFSGRTIRAALDALNDLGRPRAVQLAVLVDRGHRELPIRADFVGKNLPTSLVERVRVSLVGIDDVDAVTIQGTAPAGEVTA
>NC_008699.1|WP_011755872.1|2586571_2587528_+|carbamate-kinase
MRIVIALGGNALLRRGEPLTADNQRANIRIAAERIATVVPDNEVVIAHGNGPQVGLLALQAAAYEDVRPYPLDVLGAQTEAMIGYVIEQELGNVLPEEQHIATLLTMVRVDPEDPAFQNPTKFIGPVYMQDEAEELAAENGWVIKQDGSAFRRVVASPEPQHIYEVPSIRSLVEDGTVVICAGGGGIPTVLEPGRILRGVEAVIDKDLASSLLAQEIGADLLVIATDVDGVYLDWGSPDQRLLTETTPQELRAFDFAAGSMGPKVEAVCRFVEQTGRSAAIGSLADIAEIVAGRAGTRVVPDGHGPASGQDRELVVSG
>NC_008699.1|WP_011755871.1|2585552_2586557_+|ornithine-carbamoyltransferase
MPVNLRGRHLLSLRHHSADEIRYLLDLSRDLKRAKYAGSERQLLQGRNVALIFEKTSTRTRCAFEVASYDQGAHVTYIDPASSQLGHKESVKDTARVLGRMYDAIEYRGFSQQVVEELAEYAGVPVFNGLTDEFHPTQMLADVLTMREHCDKPLHEIAFAFMGDGRNNVANSLLLVAAKLGMDVRIGAPKELWPEDELVKLCHDLADVSGARITITDDPTQAVAGVDFIYTDVWVSMGEPVESWAERVERCLPFQVNADLLHATGNARVKVLHCLPAFHNTETKVGHQVVAQYPQLANGIEVTEDVFESAANISFDQAENRMHTIKALLVASLA
>NC_008699.1|WP_011755870.1|2584228_2585524_+|arginine-deiminase
MAIEQLPRAAVEETVAEPRVGVWSEVGRLRRVMVCAPGLAHLRLTPDTCDELLYDDVIWVGQAKRDHYDFVMKMRDRGVEVLDMLQLLVDVVRYPEGRNWILDRKVTDDQVGPGLVHEVRAWLESLPAEKLAEFLIGGVAFGDVPDDMAGPFLRAFRDAEVQQFVLPPLPNTTFARDNSSWVYQGVTLNRMYWGARRQETLLTTAIYRFHPSFAGEDFRVWFGDPDQQPRDRGNATIEGGDVMPIGNGAVVIGMGERTSQQAITQVARSLFAAGAADRVIAAGLPRMRAAMHIDTVFTFCDRDVVTAYGPVVDAINSFSLRPDDSSPSGLDIRHEGKHFVDVVSDALGTPMRVVPTGGDRYGSAREQWDDGNNVLAIEPGVVVGYDRNTHTNTQLRKAGIEVITIDASELGRGRGGGRCMTCPILRDPVDY
>NC_008699.1|WP_011755869.1|2582617_2584087_+|arginine-ornithine-antiporter
MTQQMVRPPSGPSPEQSARGAGTLALPALIALVVGSMIGSGIFALPSQMAGSAAPGPLLIGWLVTGVGMLMLAFVFQTLSRRKPDVDGGVYGYARAGFGNYLGFTSAWGYWISAWIGNVGYLVLLMSTLGYFVPAFEGGNTVAAIIGASVVLWVVQALTLRGVQSAAFVNTLVTIAKIVPLLTFIAIAAVGFKAGIFTADVWGDSAGLGSTLDQVKNMMLVTVWVFIGIEGAAVYSQRATRRSDVGRATVIGFVGVLALLLAVNVLSYGLMSQAKLAGLEDPSMAGLMRQEVGAWGTGFISIGLAVSVAGALLAWVLLSVEILRLPAREGVLPRQLGTENRYGAPSVALWLTSGCVQLMLLWTLVNENTYTDLIYLATSLILLPYLWSALYQVKLAISGESYAQGESRTRDLLVGLVALAYAVWLVYAGGWEYVLVAGIFYLVGTALYVWARSQARAAIFTVAERAVVAVVVGLSIAGVIGLVQGFVSI
>NC_008699.1|WP_011755868.1|2581357_2582389_+|NADPH:quinone-reductase
MRAVVYQQTGPSSVLEVVERDLPVPGPGEVRVRVVRAGVNPTDWKFRAGMMTEYDEVVPGQDGAGVVDAVGEGVDGLAVGDRVWLVLAQAGRAYGTAAELTVQPAARVVPLPADASFDLGASLGVPAVTAHRALTAAEGGPSRLWPGALEGRVVLVAGGAGAVGNAAIQLARWAGATVVTTVSSAEKAALARAAGADHVVNYREPGAAQAILETAPDGVDLAVEVAPAQNIELDLDVVRVHGTVSIYANNGGDTLTMPLRAAFGKNLRFQFLILYTLREDLLRAAVEDISVALAAGALRVGEEAGLPLHHYPLAQAAEAHDAVEGGVVGKVLLDVGSAADRDL
>NC_008699.1|WP_011755867.1|2580026_2581346_+|hypothetical-protein
MSQDAWSSAGSRHDHDATSDRLYTPEDLAGYAARRDARAGAGSRGPSAGPTDPLTDPLTAPLADPGLEPPVGTAPTRVPASPPPSGPPPSYRPAGPPPSAPPSVPVVLVAEGEPLDPEQPADAGELRRFMTATDFLDRRDAAQEHGPATWGWRGAVRRWSGGLVTPRMGPAEQAYERDRQAIQKDFDGPRTIAFINPKGGAAKTTGVLAAGYTFGTVRGGGVVAWDNNETRGTLGIRGTRSAHRNTTRELLEDLERFTDVYQSRIGDLGAFVRSQGDAHFDVLASDERPDVTGTIRAQDFDAVHKLLERFYRIILVDTGNNMRAENWLAAAGAADLLVVTSTVREDTGYSGLWMLDALQDAGYQNLKYKAITVLSDPSATVDTKLAADLVDVYQQRTREVYRVPYDPALVAGSVVPYSQLSRGTKREWLKACAGMAAAL
>NC_008699.1|WP_011755878.1|2595121_2596189_+|quinone-dependent-dihydroorotate-dehydrogenase
MRGERGSKPSVYSLFFDGVLTRTDPERAHHGAFRAIRAARPVLASRRTPGEQVTALGLTFPNVLGLAAGFDKNAVGIDALAALGFGHVEIGTVTGEPQPGNPKPRLFRLPEDRAIVNRMGFNNDGAEVVARRLAERSRGRDRLGHRSRPVLGVNIGKSKVVPDDDQAAVEADYEKSARLLAPYADYLVVNVSSPNTPGLRNLQAVEKLRPLLEHVRRTADAVTRTRVPLLVKIAPDLADEDVLGVADLALAIGLDGIIATNTTISRAGLRTPADRVGEIGAGGLSGRPLTGRALEVLRLLRERVGPDLTLVGVGGISTVQDARDRLTAGADLLQAYSAFVYEGPLWPRRIVRGVA
>NC_008699.1|WP_011755879.1|2596185_2597007_+|orotidine-5'-phosphate-decarboxylase
MIPFGSRLHAAIADRGPLCVGIDPHAGLLSDWGLGDDVAGLETFALEVVEAIAPYVSVVKPQSAFFERFGSRGIAVLERVIAQSRAAGALVLLDVKRGDIGSTSQAYADAYLDPTSPLASDAITVSPFLGFGSLDPIVETARTHGAGLFVLALTSNKEGPEVQHARVDGVAGGGTVAGLMLDHLRRLNAEASPLGSFGAVVGATIGSTDEDLAFNGPVLAPGFGAQGGTIADVRRLFGAAAAVLPSSSRDVLRLQDPDVMRDFVVRTNDELRS
>NC_008699.1|WP_011755880.1|2597003_2597435_+|hypothetical-protein
MRRLLAVAVLLPLLAACGSGPDEYCAAVKDHQQELSDLVGSGAPDALLKALGPFRDLRDHAPEDITDEWQQVVGRIEALAEALDDAGVDPATYDRDHPPAGVSAADKARIDAAAAQLGSGTTLRALQDLDQQARDVCRTPLTL
>NC_008699.1|WP_041547624.1|2597543_2597864_+|30S-ribosomal-protein-S13
MALPPLTPEQRQAALEKAAASRRERAEVKNRLKNSGASIVDVLQEGQRNEVIGKMRVVDLLQSMPGLGKVRARQVMERLGIAESRRVRGLGAKQVAALEKEFAARD
>NC_008699.1|WP_011755882.1|2597879_2598464_+|guanylate-kinase
MTAPSTRRSRLVVLAGPTAVGKGTVAAEVRRTHPEVWISVSATTRPPRPGEENGVHYWFVSDEEFDAMVEQGNLLEWAVVHKAARYGTPRQPVELALASGRPAMLEIDLQGARQVRATMPDALFVFLKPPSWDELVRRLVGRGTETETERERRLETAREELAAEAEFDLTIVNHEVNAAAEELVALMAPSPTDL
>NC_008699.1|WP_011755883.1|2598473_2598806_+|DNA-directed-RNA-polymerase-subunit-omega
MSGPTIAAEGVTNPPIDELLTKTDSKYKLVLYSAKRARQINAYYSQLGEGLLEYVGPLVDTHVQEKPLSIALREINEDLLTCEDVDPAELAAEEAAAQAAAADAGSSFSE
>NC_008699.1|WP_011755884.1|2598780_2600091_+|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC
MRAARSASDPLTTSSTHEAASPSGGRPAARPEQAPRVVLGVSGGIAAYKVCELLRRFTESGHDVTVVPTVAALEFVGAPTWAALSGKPVSTEVWNDVHQVPHVRIGQWADLLVLAPATADLIAKAAHGLADDLLTNTLLTARCPVVLAPAMHTEMWEHPATQANVATLRERGVVVIEPAEGRLTGKDTGKGRLPEPDAIFDLCRELLTRGSGAPDLAGRQVLVTAGGTREYLDPVRFLGNRSSGLQGYALARAAAARGAEVTLVAANVSLPDPAGVKIVRVGSTAELRDAVLAGAASADAVVMAAAPADFRPVDVSEAKIKKDVDGSAPTVTLAQNPDILHEISTHRARPGAVIVGFAAETGDETGTVLDLARAKLARKGCDLLVVNDVSGGAVFGSPENQAVILAADGAEVEVPRGPKNALAHIIWDQVASRLQD
>NC_008699.1|WP_011755885.1|2600172_2601363_+|methionine-adenosyltransferase
MTGRLFTSESVTEGHPDKIADQISDSVLDAMLELDPTSRVAVETLLTTGVVVVAGEVTTTGYVDVKDVVRRRIIEIGYDSSVKGFDGHSCGVMVAIGGQSGDIAQGVDTGHESRTGSVDAMDKQGAGDQGLMFGYACDDTDVLMPLPIVIAQRLAEQLTAVRKDGTLPYLRPDGKTQVTIEYDAENRPVRVDTVVLSSQHDEDTELDTLEADVKKHVIDPVLATFPIPSEGYRLLVNPTGRFVVGGPMGDAGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLATRCEAQVAYAIGKAQPVGVFVETFGTGVVDDERIQEAVLEVFDLRPAAIIRDLDLLRPIYAKTAAYGHFGRELPEFTWERTDRADALRAAAGL
>NC_008699.1|WP_011755886.1|2601487_2603521_+|primosomal-protein-N'
MTDSEEQPELLPGMVRASVKASRAKARATRARKAAEAEPAAVDPVARVLVDLPLAHLDRPFDYAVPAAMADDARPGARVKVRFAGQDVDGYLVARAAESEHLGRLAPLRRVVSPEPVLAPQIEALSAELAERYAGTRSDVLRLAVPPRHATTEKAPSPPVPSWGGPDPAAGEAAWAGHEPGAAFLRHLTAGGIPRAVWTAAPAADWPVMIAHAVAATYASGRGSLVCVPDHKDVARVGAALTDVLGEGRHVTLTADSGPAARYRDFLAVSRGARRVVVGTRGAAFAPVHELGLVVVWDDGDDLHAEPRAPYPHTRETLLLRAEREGAAALVGGFVRTVEGEYLLRTGWAHELVPAREEVRRRVTVSVAGDAGDRDVHARGVRMPRAIHQAIREALDDGPVLVQTPRVGYVNALACERCRTPARCAACQGPLALTGPTTPPACRWCGILAEGWACRECGFRGLRAPVLGDARTAEELGRAFPGTTVRTSSGEAVVAAVGARPQVVVATPGAEPVAEDGYAAVVLLDTWLLLSRIDLRAEEEALRRWANAAGLVRPGGRVVAVGDAAHPALQALVRWDPAGFAARETAERVEAHLPPASRLATITGEPGAVDDALILLDAPSGAEILGPVDVGEGESRVVVRVPRAQGPALSHALGQLQRVRSSRKLDAVRIQVDPPTL
>NC_008699.1|WP_011755887.1|2603596_2604142_+|peptide-deformylase
MAIQPIRLFGDPVLRKPAIEVVDFDKELRRLVADLTDTMMDAPGAGLAAPQIGVGLRVFTWYVDGEPGHLVNPQLDLSDELQDGPEGCLSIPGLSVDCQRAMAAVARGFNMYGDPVTIEGTELLARALQHETDHLDGVLFIDRLDTEARKAAMKAIRESEWFGLDAPQVKVSPHATHGLGF

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Crispr_ID: NC_008699_25

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_25

3379146-3379230

Orphan

Consensus_repeat	Method
TCCCCGGTGAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_25

>merge|NC_008699|25|3379146-3379230|CRISPRCasFinder
TCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGGCGAAACTTCGGGCCAGAAGTTCCAACATCCCCGGTGAACCGGGGAAACCG

>NC_008699|25|25|3379146-3379230|CRISPRCasFinder
TCCCCGGTGAACCGGGGAAACCG	GAACTGTTGGGGCGAAACTTCGGGCCAGAAGTTCCAACA
TCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011756612.1\|3373705_3375067_-\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NC_008699.1\|WP_041547830.1\|3379233_3380919_-\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NC_008699.1\|WP_011756610.1\|3371934_3372738_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011756608.1\|3370301_3371180_+\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|132002
NC_008699.1\|WP_011756607.1\|3369699_3370305_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NC_008699.1\|WP_011756626.1\|3388520_3391337_-\|translation-initiation-factor-IF-2	unknown	unknown	gnl\|CDD\|235401
NC_008699.1\|WP_011756611.1\|3372747_3373494_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224861
NC_008699.1\|WP_011756609.1\|3371224_3371923_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226317
NC_008699.1\|WP_011756613.1\|3375063_3377292_-\|polyribonucleotide-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|131743
NC_008699.1\|WP_011756625.1\|3387859_3388348_-\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|234787
NC_008699.1\|WP_011756614.1\|3377569_3377845_-\|30S-ribosomal-protein-S15	unknown	unknown	gnl\|CDD\|180170
NC_008699.1\|WP_011756621.1\|3384818_3385076_+\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|376329
NC_008699.1\|WP_011756620.1\|3382732_3384781_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|182066
NC_008699.1\|WP_011756618.1\|3381008_3381776_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_008699.1\|WP_011756619.1\|3381772_3382729_+\|1-phosphofructokinase-family-hexose-kinase	unknown	unknown	gnl\|CDD\|274804
NC_008699.1\|WP_011756616.1\|3378782_3379028_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011756622.1\|3385079_3386054_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379825
NC_008699.1\|WP_011756624.1\|3387003_3387873_-\|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl\|CDD\|235113
NC_008699.1\|WP_011756623.1\|3386050_3386983_-\|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl\|CDD\|235536
NC_008699.1\|WP_140404050.1\|3378104_3378773_+\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|226309

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011756612.1\|3373705_3375067_-\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	1.21282e-122
NC_008699.1\|WP_041547830.1\|3379233_3380919_-\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	6.12712e-162
NC_008699.1\|WP_011756623.1\|3386050_3386983_-\|bifunctional-riboflavin-kinase/FAD-synthetase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	3.26344e-134
NC_008699.1\|WP_011756608.1\|3370301_3371180_+\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	1.97854e-110
NC_008699.1\|WP_011756607.1\|3369699_3370305_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	1.19e-12
NC_008699.1\|WP_011756626.1\|3388520_3391337_-\|translation-initiation-factor-IF-2	gnl\|CDD\|235401	PRK05306, infB, translation initiation factor IF-2; Validated.	0
NC_008699.1\|WP_011756611.1\|3372747_3373494_-\|hypothetical-protein	gnl\|CDD\|224861	COG1950, COG1950, Predicted membrane protein [Function unknown].	0.00185677
NC_008699.1\|WP_011756609.1\|3371224_3371923_-\|hypothetical-protein	gnl\|CDD\|226317	COG3794, PetE, Plastocyanin [Energy production and conversion].	0.000217815
NC_008699.1\|WP_011756613.1\|3375063_3377292_-\|polyribonucleotide-nucleotidyltransferase	gnl\|CDD\|131743	TIGR02696, polyribonucleotide_nucleotidyltransferase, guanosine pentaphosphate synthetase I/polynucleotide phosphorylase. Sohlberg, et al. present characterization of two proteins from Streptomyces coelicolor. The protein in this family was shown to have poly(A) polymerase activity and may be responsible for polyadenylating RNA in this species. Reference 2 showed that a nearly identical plasmid-encoded protein from Streptomyces antibioticus is a bifunctional enzyme that acts also as a guanosine pentaphosphate synthetase.	0
NC_008699.1\|WP_011756625.1\|3387859_3388348_-\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	3.15138e-45
NC_008699.1\|WP_011756614.1\|3377569_3377845_-\|30S-ribosomal-protein-S15	gnl\|CDD\|180170	PRK05626, rpsO, 30S ribosomal protein S15; Reviewed.	1.32395e-50
NC_008699.1\|WP_011756621.1\|3384818_3385076_+\|HPr-family-phosphocarrier-protein	gnl\|CDD\|376329	pfam00381, PTS-HPr, PTS HPr component phosphorylation site.	1.26727e-21
NC_008699.1\|WP_011756620.1\|3382732_3384781_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|182066	PRK09765, PRK09765, PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional.	4.48761e-126
NC_008699.1\|WP_011756618.1\|3381008_3381776_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	3.46311e-82
NC_008699.1\|WP_011756619.1\|3381772_3382729_+\|1-phosphofructokinase-family-hexose-kinase	gnl\|CDD\|274804	TIGR03828, pfkB, 1-phosphofructokinase. This enzyme acts in concert with the fructose-specific phosphotransferase system (PTS) which imports fructose as fructose-1-phosphate. The action of 1-phosphofructokinase results in beta-D-fructose-1,6-bisphosphate and is an entry point into glycolysis (GenProp0688).	1.6553e-103
NC_008699.1\|WP_011756622.1\|3385079_3386054_-\|hypothetical-protein	gnl\|CDD\|379825	pfam16327, CcmF_C, Cytochrome c-type biogenesis protein CcmF C-terminal. This C-terminal region of CcmF, one of the cytochrome c-type biogenesis proteins, is associated at the C-terminal with Cytochrome_C_asm family pfam01578. It is possible that it is this domain which delivers reductant to haem on CcmE.	0.0020545
NC_008699.1\|WP_011756624.1\|3387003_3387873_-\|tRNA-pseudouridine(55)-synthase-TruB	gnl\|CDD\|235113	PRK03287, truB, tRNA pseudouridine synthase B; Provisional.	3.31909e-151
NC_008699.1\|WP_140404050.1\|3378104_3378773_+\|L,D-transpeptidase-family-protein	gnl\|CDD\|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	1.77956e-20

>NC_008699.1|WP_011756616.1|3378782_3379028_-|hypothetical-protein
MGYGLGIFLLALGLILALAVTDSISNVDLTMVGWILAAAGALVLVLTAATLARARRSTAVTTHADGSRTVSERRDDVPPAV
>NC_008699.1|WP_140404050.1|3378104_3378773_+|L,D-transpeptidase-family-protein
MLMAAPAPTQALEQPGTRGRAWTPPWAPLVPERTTQVVRTISSHQFCRKVWCTVTQAWERDGDGHWSKAREFRSTIGLRGWGKQREGDNRSPVGVYRIKVTFTTGSENPGEMPWRRRRPTSVVSSSAGPNYNTWLEARGVTSGDRPSMRSGWVVDYNRVRLRPGVGPRPVPGKGSGIFYHTSKPGHRWAPTAGCTQVGNPRQMRWLLTWLRPEARPRIVQDR
>NC_008699.1|WP_011756614.1|3377569_3377845_-|30S-ribosomal-protein-S15
MSIGTDAETKKKIIAEYAKTEGDTGSPEVQIALLSHRISHLTEHLKQHKHDHHSRRGLLLLVGQRRRLLNYLQKTEIERYRSIVERLGLRR
>NC_008699.1|WP_011756613.1|3375063_3377292_-|polyribonucleotide-nucleotidyltransferase
MTDPEISAVETVLDNGKFGTRTVKFETGLLARQAAGAVTAYLDEDTMLLSATTAGKHPKDHFDFFPLTIDVEERMYAAGKIPGSFFRSEGRPGEDAILTCRLIDRPLRPTFKKGLRNEVQVVITVMALNPDTPYDVLAINAASLSTQLSGLPFSGPVGGVRVALIEGQWVAFPTHSQLENAVFDMVVAGRVTETGDVAIMMVEAEATEQTWDLVRSGTQAPTEEIVAGGLDAAKPFIKQLCEAQVELANVAAKPVQDFPVFLDYEDDVYDAVEAAVKAELAAAMKIADKQERNDRTDELKDEVLAKLGEQFEGREKEIGAAFRSVNKQVVRESILRDKVRIDGRGLADIRPLHAEVGVIPRVHGSALFERGETQILGVTTLDMLKMEQQLDTLSPEKHRRYMHKYVFPPFSTGETGRVGSPKRREVGHGALARRALLPVLPTREEFPYAIRQLSEAMGSNGSTSMGSVCASTLALLQAGVPLKAPVAGIAMGLVSGEIDGQLQYVALTDILGAEDAFGDMDFKVAGTREFVTALQLDTKLDGIPAEVLAQALTQARDARLTILDVMAEAIDEPEEMSAYAPRIITITIPVDKIGEVIGPKGKIINQIQDDTGASISIEDDGTIYIGATNGEAAEAAKNAVNAIANPTMPEVGERYLGTVVKTTNFGAFVSLMPGKDGLLHISKLRSLAGGKRVDAVEDVVSVGQKIQVQIAEIDDRGKLSLVPVVEGDQADSDTAEAGSEEE
>NC_008699.1|WP_011756612.1|3373705_3375067_-|insulinase-family-protein
MTPRSAEASPVTRQSSSGGSPSSRGTTRTLQTTTDADGQVTSRVRRTVLPSGLRVISEHQAGVRSAAIGVWVGVGSRDESPSLHGCSHFLEHLLFKGTTERSALDISVALDAVGGEFNAFTAKEYTCFHARVLDEDLPLAVDVLGDMITASTLTAEDVEAERDVILDEIAMHDDDPDDVVHNLFAEQAWGDTPLGRPIAGTVGSIRSLSRDQVRRFYRRHYRPANVVVAAAGNVDHAQLVRQVRTAFARNGWLDGRDTPVVPRHGTRKRVRPGVLATTRPFEQVNVVLGMEGLRRDDDRRFALGVLNTALGGGTSSRLFQEVRERRGLAYSVFSFATHHADSGLVGVSVGCLPNKLDDVLAVVREELAKVAESGITAEELARGKGQLRGGLVLGLEDSASRMSRIGKAELVHDRLMSIDEVIARIDGVTLEEVQSIAAEVFARPEILAVVGPA
>NC_008699.1|WP_011756611.1|3372747_3373494_-|hypothetical-protein
MSLTETSEVFVAVEESALNDLITAVCTTRPHLLDYGSPAFVPASSVSATQMAPIPFPGSPGLQWSVRLSTPVLDLFKQDVALPPELSLGAGQFSLSTRVRLCVDCASRGRNEPPGEDPKGHDHPEHDPKDPDHRDDRDDPLWPDDRDDWGKARNPTCCVLDVFAVGHLVSTWAGGQQAIGFALDSVEIVDIEPNALESVIECLLTMVLRSVLATLSLPVTALELGAFTLTPTQGPLIDVNRVLARGDF
>NC_008699.1|WP_011756610.1|3371934_3372738_-|hypothetical-protein
MSEIIAAIDEGAAQQLFDTEVAALGPQSTSGSSSLGPFTVSYAVTGTLSNGTVDLIAPATVEIADLRLDWHVDLSFQLDIGDFIPDIHIPQVCVHIPCVGDVCTPKIDIVWPTVTVPVSFGDYVLTTVDLGVALSLVAGAWTVEGIVQGVPSLQFGASTAALLAAIGLAVSAAVAWVPLIGPFLAVLVGAVVAAIGIAGLTGLLGPLITPFVSGTRFPITEVPAHFEVLPASGPFDPAVFVTVTSLGAEVQNNPPEDELVVLADIQP
>NC_008699.1|WP_011756609.1|3371224_3371923_-|hypothetical-protein
MTEYLDSRALRNIDCYGQRFMRPGTYPYALVPAGGAGAGGDFPYVVEVGEPSSKRERDMHQTTVTVSFVKERHGDCCDERTVDPGRFVPDQERVTVEAGDMVVWNSPDAAARPFAVAGQKEFFGSSVLTNECGYTHVFTTPGEHEYVDANGSGLRGVVRVKDPRPRNAEELRAWQSRLGEGTLVLISDGRPEPAEVEVVLGQTVFFAVVTGPGVTITDAALVAERPHEAGAA
>NC_008699.1|WP_011756608.1|3370301_3371180_+|RNA-polymerase-sigma-70-factor
MSEDPFVAHRSLLFTVAYEMLGSVADAEDVVQETWLRWAALPAADRGEVRDPRAYLVRIVTRLSLNRLRTLTRLREEYVGEWLPEPLLTSPDVAEDVELAESVSIAMLAVLETLLPTERAVFVLREVFDVPYDEIAAALDKSSAAVRQIASRARKYVAARRPRTSVSRAEQERVVERFLAALTTGDVVGLLDVLAPDVLLVGDGGGLVPTVPSPVRGAARLAPVMARFAELAPGTTAVIVDLNGGIAARIDPGGQNDTAVSFVIEGHRIAQIYAIRNPHKLQRLAEVAELRR
>NC_008699.1|WP_011756607.1|3369699_3370305_+|carboxymuconolactone-decarboxylase-family-protein
MTTTTTDHATRIPPAEITGLKGALIKRMIEKKLGKVPTAVGIYWHNPKVLFATFGLGGKLQKWDACDEGLKSFAHMAVASLVGCTWCLDFNYFEAHNSGLDVEKARQIPRWRETDVFTSLERDVLEYAEAMSQTPPTVTDELVDRLHAELGAAAVVELTSVISFANMTTRGNIALGIESDGFAAACGLKPLAERPHVASAS
>NC_008699.1|WP_041547830.1|3379233_3380919_-|phosphoenolpyruvate--protein-phosphotransferase
MVTSPEARSTLRGTPVVPAVAYGPAVLVRSEVSPDAIARFDPSGLDPETALQTYESAAQSVSDGFARKAEKASGAAAEVLTASAGLARDKGLRGAVRKHLSAGDDLLAAVHAGVEQFVTVFTGMGGLMAERVTDLRDIERRIVARLVGEPEPGVVVPETPAVLLAEDLAPSDTAGLHPAVVLGLVTERGGPTSHTAIIARQLGIPCVVGVHGAMAVPAGTPLLLDGVAGTVELGPDPATAQERVAADAALRAALASWSGPGGTADGVPVKILANVADGESARAASSAPVQGVGLFRTELCFLNRQDEPSVEEQASIYGEVLGAFGNERYVVVRTLDAGSDKPVAFATHVGEENPALGVRGLRLSFDNPGLLDRQLEGIAKAAAATGTEAWVMAPMVATVAEAAEFSTKVRAHGLKAGVMIEVPSAALLAHRVLEVVDFLSIGTNDLTQYTMAADRMATDLAHLTDPWQPAVLQLIAITAEAGFHAGKPVGVCGEAAADPLLACVLVGMGVTSLSMAAAAVRPVGARLATVPMDLCEDAAEVALAATDPASARDAVRTLLLG
>NC_008699.1|WP_011756618.1|3381008_3381776_+|DeoR/GlpR-transcriptional-regulator
MYAEERQQAMAQLVAEHGRLSVAVIAEQFDVTTETVRRDLSTLERMGLVRRVHGGAVPASSLAVIESGLGERDQANTSQKEAIAKAALEQLPPPGGTVLLDAGSTTSRFAVLLPRDHRLTVITHAVPVAARLTGMPQIDLHLLPGRVRSTTQAAVGADTVTAVHKLKVDVAFLGTNGISVEHGLSTPDHDEAAVKRAMVGAARRVVCLTDSSKAGTDAAVRFAALAEVDVLVTDDHLPVGDRVAFEVAGVEVVTA
>NC_008699.1|WP_011756619.1|3381772_3382729_+|1-phosphofructokinase-family-hexose-kinase
MILTLTANPSLDRTVVLAGRLKRGKVIRADSVISQAGGKGVNIARACIAAGVPAIAVLPAAKDDPFVLELLAAGIDCRPVHHDGSLRVNITITEPDGTTTKLNSPGPELTEPVRRALADALRHRAAAADWVVLAGSLPPGAPPEWYAELVVLLRECGARVAVDTSDAPLRALVDRLPTAAPHLMKPNGEELASFTGDDPELLEADPYAAAKAARTLVESGVESVLATLGARGAVLVTADGAWHAAPPPTPVVSTVGAGDSSLFGYLLGELRGHRPEERLALAVAYGSAAAGLPGTTMPHPHQVRPDLVSVRALDLSEG
>NC_008699.1|WP_011756620.1|3382732_3384781_+|PTS-sugar-transporter-subunit-IIA
MSDLINAELVRLDADLGADKHTVIRALARIVGDAGRAGDADQLVADAFAREATSATGLPGGIAIPHCRTAGVAEPVLAFARLQPAVDFGAKDGPADLVFLIAAPTGGDNTHLQLLTKLARALVKPAFTDSLRAAGTPAEVAELVTGAIGAAPQPAAPAAPAASAAPRRLVAVTACPTGIAHTYMAAEALEAAAARAGVDLQVETQGSAGATPLDPATIAAADAVIFAVDVGVRDRHRFAGKPLVSSGVKRPFDQADAMIAEALRYADDPDAPRVEGSAADAATTSRSTAGESWGARTRRVLMTGVSYMIPFVAAGGLLIALSFLLGGYEIVGPYGDIAVNNTLFDLPDPDALGLEHALLGSGLAAYIGALFFIIGKTAFMLFIPALAGYIAYAIADRPGIAPGFVMGGLAANIFNVQSSGDSPVSIPATGFLGAIIGGVLAGLIAHWVGGRQVPAWMRGLMPVLIIPLVTSIVAGLLMIVVFGKPIGWLMDQLNDGLNSLSGSSAMVLGAILGLMMAFDMGGPLNKVAYTFAATGVGGAALASDAPQLKIMAAVMLAGMVPPLALALATVVRPGLFNQAERENGKAAWALGASFITEGAIPFAAADPLRVIPAIMCGSAVTGGISMALDVGVRAPHGGIFVLFAVSNILGYLIALAVGTLVGAAAVIGLKSLGKPDPDLAIG
>NC_008699.1|WP_011756621.1|3384818_3385076_+|HPr-family-phosphocarrier-protein
MLTKTVVVGSSVGLHARPAQLIAQAAEELDSEVLIGIPGGDPVDASSSLMIMTLGAGPGDQVEVSSDDQAALDTIAALVEQDLDA
>NC_008699.1|WP_011756622.1|3385079_3386054_-|hypothetical-protein
MTVPPPPEPIAAADAWFLQHGLSYFVPERRADVRNALRLRRTVPLLLLVALLAAAAGAALAWVSGQFSAAPATLVSLGLAAAVWYALTALHARQIVAWGLKRTFGGLRRLLPMTTRALPLLLLAITFLFINTEMWQVGGNLSVGSLWLVVLLFALLAVAFLLVRLPEEVDRADDAVDDALLLRACAGSPLEETCRELVEDPDADPAAYAEVTGFERWNLILVLMVVQVVQVLLLSLAVFAFLMVFGGLIMTGPVIEAWQAGDDFSESRALVQVSVFLAAFSGLYLTVSTVTDETYRAQFFSGVTRELERAVGMRAVYLALRERS
>NC_008699.1|WP_011756623.1|3386050_3386983_-|bifunctional-riboflavin-kinase/FAD-synthetase
MQIWRSLEEVPSGLGPTAVVIGNFDGVHLGHRHVVNRARETAAERSLTVVAVTFEPHPMAVLRPEHAPTTLTSLEIRAELLADAGADAVLVLPFDRGVAAWTPEEFVERVLVDALHAAVVVVGANFRFGNKAAGDVATLRQAGERHGFEAEGIALDGGPQVWSSTYVRMSLAAGDVAGAAEALGRPYAVRGVVVRGDQRGRDLGFPTANVPADELTAVPPDGVYAGRLRRLDTGETFPAAISVGTNPTFDGVRDRRVEAYVLDRTDLDLYGVEVEVSFVDRLRGMVAFESIDKLVAQMNDDVDRARELLA
>NC_008699.1|WP_011756624.1|3387003_3387873_-|tRNA-pseudouridine(55)-synthase-TruB
MTTSEAGLVVVDKPGGLTSHDVVSRVRRLTGTRKVGHAGTLDPMATGVLVLGINRATRLLGHLMLTEKAYDATIRLGVATSTDDAEGEVTATASAAGLDEATVRAAAAEFVGDLLQVPTAVSAIKVDGKRAYQRVRAGEEVALEARPVTVHELVVHEVRPAGDTCDLDVAVRCSSGTYVRAIARDLGARLGVGGHLTALRRTAVGPYGLDVAHTLDELGEELVVLPVAAAARAAFASRDLDDAQATDVRFGRALDLDLPGLTAVFAPDGEFLALYEPRGGAAKAVAVFV
>NC_008699.1|WP_011756625.1|3387859_3388348_-|30S-ribosome-binding-factor-RbfA
MSNPRIRKIADRIQVVVAEMLERRIKDPRLGFVTVTDVRVSGDSQQATIFYTVLGEDDEAARTASAVALESAKGLLRSEVAKQLGMRHAPTLEFVHDALPESARQLDEVLARAKAQDEALAAGRGTAYAGEADPYKKPRPADADEPDDSGEPGEFDGVDDDE
>NC_008699.1|WP_011756626.1|3388520_3391337_-|translation-initiation-factor-IF-2
MAKTRVHELAKEFGVESKFVLEKFKEMGEFVKSASSTVELPAEMRFRKEYGEKLKAEASAAPAAPAEKPAAKKAPAKKAAATAEPEALAAEPAAEPAAAEAPAAAEAEAPAAKAAAPKPGPKPAPVAEQPAPPAEPEAPEAPEAPAASAAPAAPKAPAPRPVGRPGAPRPGNNPFASSQGMGRRPAPGAPAAPGAGDNRPPRPPAAREGGVPGRPGMPRPNPAMMPKSPSAFGAGPGGRGPARPGAPGRGGAPGRGGAPGRGGVGTGAPGRGGAPGGGFGPSGGGRPGGGRPGQRGQTQGAFGRPGGPSRRGRKSKRARRQEFEAMEAPTIGGIRVRKGNGETVRLPRGASLTDFAERINVEPAQLVQMLFSLGEMVTATESVNDETLELLGEELNYVVEVVSPEDEDRELLESFDIEFADDEDDEGHFEARPPVVTVMGHVDHGKTKLLDALRHANVASGEAGGITQHIGAYQVHTDVDGEDRKITFIDTPGHEAFTAMRARGSQSSDIAVLVVAADDGVMPQTVEALNHAKAAGVPIVVAVNKIDKPEADPTKVRGQLTEYGLVPEEYGGDTMFVDVSAKSELNLDKLLEAVVLTADASLDLRANPNRDAQGLVIEAHLDRGRGPVATILVQRGTLHVGDSIVAGPAHGRVRAMLDEYGNELTEATPSRPAMVLGLSTVPGAGQNFIVVEDDRMARQIAEKREARERAAMQAKRRVRRTLEDFMASMEKGESQELNLILKGDVSGSVEALEDALAKIDVGDDVSLRVIDRGVGAITETNVDLAAASDAIIIGFNVRPQGKATELADREGVEIRYYTVIYQAIEEIEAALKGMLKPEFEESTLGQAEIRAIFRSSKVGNIAGCMVISGVIRRNAKVRVIRDGAVVADNLDLASLKREKDDASEVREGFECGLVLRNFQDIKEGDIVEAFEMREIPRA

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Crispr_ID: NC_008699_26

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_26

3655170-3655255

Orphan

Consensus_repeat	Method
TTCCCCGGTGAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_26

>merge|NC_008699|26|3655170-3655255|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCAAAATTTCGGGCCAGAAGTTCCAACTTCCCCGGTGAACCGGGGAAACCG

>NC_008699|26|26|3655170-3655255|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCG	GAACTGTTGGGCCAAAATTTCGGGCCAGAAGTTCCAAC
TTCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011756877.1\|3651227_3652244_-\|methionine-synthase	unknown	unknown	gnl\|CDD\|239426
NC_008699.1\|WP_011756872.1\|3645626_3645929_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011756882.1\|3656399_3657950_-\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237045
NC_008699.1\|WP_011756873.1\|3646043_3648302_-\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NC_008699.1\|WP_011756889.1\|3665659_3665986_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011756886.1\|3662368_3663079_-\|DUF2344-domain-containing-protein	unknown	unknown	gnl\|CDD\|274865
NC_008699.1\|WP_011756878.1\|3652240_3653341_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_008699.1\|WP_011756875.1\|3648977_3650570_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NC_008699.1\|WP_011756881.1\|3655265_3656381_-\|glutamate-5-kinase	unknown	unknown	gnl\|CDD\|235460
NC_008699.1\|WP_011756884.1\|3658333_3658642_-\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NC_008699.1\|WP_049774404.1\|3654627_3655086_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197318
NC_008699.1\|WP_011756879.1\|3653348_3654548_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_008699.1\|WP_011756876.1\|3650648_3651185_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153228
NC_008699.1\|WP_041546683.1\|3664337_3665543_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340897
NC_008699.1\|WP_011756874.1\|3648330_3648978_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NC_008699.1\|WP_011756883.1\|3658047_3658302_-\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NC_008699.1\|WP_011756871.1\|3644275_3645613_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|131034
NC_008699.1\|WP_011756885.1\|3658807_3662020_-\|Rne/Rng-family-ribonuclease	unknown	unknown	gnl\|CDD\|273254
NC_008699.1\|WP_011756887.1\|3663096_3664287_-\|winged-helix-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|377630
NC_008699.1\|WP_011756890.1\|3665975_3666206_+\|Arc-family-DNA-binding-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011756877.1\|3651227_3652244_-\|methionine-synthase	gnl\|CDD\|239426	cd03310, CIMS_like, CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by transferring a methyl group from 5-methyltetrahydrofolate to L-homocysteine without using an intermediate methyl carrier. The active enzyme has a dual (beta-alpha)8-barrel structure, and this model covers both the N-and C-terminal barrel, and some single-barrel sequences, mostly from Archaea. It is assumed that the homologous N-terminal barrel has evolved from the C-terminus via gene duplication and has subsequently lost binding sites, and it seems as if the two barrels forming the active enzyme may sometimes reside on different polypeptides. The C-terminal domain incorporates the Zinc ion, which binds and activates homocysteine. Side chains from both barrels contribute to the binding of the folate substrate.	3.74232e-39
NC_008699.1\|WP_011756882.1\|3656399_3657950_-\|GTPase-ObgE	gnl\|CDD\|237045	PRK12296, obgE, GTPase CgtA; Reviewed.	0
NC_008699.1\|WP_011756873.1\|3646043_3648302_-\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NC_008699.1\|WP_011756886.1\|3662368_3663079_-\|DUF2344-domain-containing-protein	gnl\|CDD\|274865	TIGR03936, radical_SAM-linked_protein, radical SAM-linked protein. This model describes an uncharacterized protein encoded adjacent to, or as a fusion protein with, an uncharacterized radical SAM protein.	3.87768e-67
NC_008699.1\|WP_011756878.1\|3652240_3653341_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_008699.1\|WP_011756875.1\|3648977_3650570_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.09695e-68
NC_008699.1\|WP_011756881.1\|3655265_3656381_-\|glutamate-5-kinase	gnl\|CDD\|235460	PRK05429, PRK05429, gamma-glutamyl kinase; Provisional.	0
NC_008699.1\|WP_011756884.1\|3658333_3658642_-\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	1.89121e-37
NC_008699.1\|WP_049774404.1\|3654627_3655086_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197318	cd09084, EEP-2, Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2. This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps, proteins.	9.84413e-13
NC_008699.1\|WP_011756879.1\|3653348_3654548_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	7.71001e-172
NC_008699.1\|WP_011756876.1\|3650648_3651185_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|153228	cd03134, GATase1_PfpI_like, A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus. A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus. This group includes proteins similar to PfpI from P. furiosus. and PH1704 from Pyrococcus horikoshii. These enzymes are ATP-independent intracellular proteases and may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For PH1704, it is believed that this Cys together with a different His in one monomer and Glu (from an adjacent monomer) forms a different catalytic triad from the typical GATase1domain. PfpI is homooligomeric. Protease activity is only found for oligomeric forms of PH1704.	5.61333e-79
NC_008699.1\|WP_041546683.1\|3664337_3665543_+\|MFS-transporter	gnl\|CDD\|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.48191e-96
NC_008699.1\|WP_011756874.1\|3648330_3648978_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	1.30943e-23
NC_008699.1\|WP_011756883.1\|3658047_3658302_-\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	2.38585e-46
NC_008699.1\|WP_011756871.1\|3644275_3645613_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	3.51826e-99
NC_008699.1\|WP_011756885.1\|3658807_3662020_-\|Rne/Rng-family-ribonuclease	gnl\|CDD\|273254	TIGR00757, Ribonuclease_E/G-like_protein, ribonuclease, Rne/Rng family. This model describes ribonuclease G (formerly CafA, cytoplasmic axial filament protein A), the N-terminal domain of ribonuclease E in which ribonuclease activity resides, and related proteins. In E. coli, both RNase E and RNase G have been shown to play a role in the maturation of the 5' end of 16S RNA. The C-terminal half of RNase E (excluded from the seed alignment for this model) lacks ribonuclease activity but participates in mRNA degradation by organizing the degradosome. [Transcription, Degradation of RNA].	3.9513e-169
NC_008699.1\|WP_011756887.1\|3663096_3664287_-\|winged-helix-DNA-binding-domain-containing-protein	gnl\|CDD\|377630	pfam06224, HTH_42, Winged helix DNA-binding domain. This family contains two copies of a winged helix domain.	9.31999e-48

>NC_008699.1|WP_049774404.1|3654627_3655086_-|endonuclease/exonuclease/phosphatase-family-protein
MVFSSTELGRPERTATWYDGCVVRAGDLVVVPTHPQAPTEPDLWRSDHAALLDAVRRHDPDLVLGDLNATDDHAPMRALTDTGLRDAVELANGGCQRTWPAGGRWQVIGLAAPPLTRIDHVLVGSRLAVVSVRTADLPSSDHRAVVAVLART
>NC_008699.1|WP_011756879.1|3653348_3654548_-|cysteine-desulfurase
MTAAAPSRTVYLDHAATTPMVPAAVEAMTAHLREVGNPSSLHASGRRARRVVEESRETIAQALNCRPGEVVFTSGGTEADNLAVKGIFWSRRDEDARRTRVLTTAVEHHAVLDAVHWLGHAEGAEVELLPVDDRARLDVDALRSAIERDPASVAVVSVMWANNEVGTLQPIHDVVALAAEHGIPVHTDAVQAVGHVPVDFAASGIDALTLTGHKLGGPYGVGALVVRREVPVRPLVHGGGQERDIRSGTLDTPAIAGFAAAVELAVKHQADHATHIGALRDELVRRVIEVVPDAHLHGAALDLGGTERLPGNAHLGFPGCEGDSLLMLLDARGIECSTGSACSAGVPQPSHVLLAMGCDADQARHSLRFSLGHTTTAADVDAVAEAIGPVVERARAARR
>NC_008699.1|WP_011756878.1|3652240_3653341_-|tRNA-2-thiouridine(34)-synthase-MnmA
MRVLAAMSGGVDSAVAAARAAEAGHDVTGIHLALSRNPQSYRSGARGCCTIEDSNDARRAADVIGIPFYVWDLSDRFHEDVVEDFMAEYAAGRTPNPCLRCNEKIKFAAVLDRALGLGFDAVATGHYARLVAGADGLVEMHRAVDHGKDQSYVLGVLDQGQLRHSLFPLGGSTKDEVRREAAERGLLVADKPDSHDICFIADGDNAGWLREKLGDRAPHHEGTIVDDDTGEVLGRHEGSYGFTIGQRKGLRIGRPAPDGRPRFVLDIEPVSGTVTVGPHERLAVHRLRGIRPRWCGTVPDRLSGTVQLRAHGEEHRAVLVRDGDEVDIELLEPAYGIAPGQAAVLYDGSRVVGSATISATDRVAAR
>NC_008699.1|WP_011756877.1|3651227_3652244_-|methionine-synthase
MTLATGVGSYPGVDQAAYDEAVRTVLGELGEGGTGLPHLPEVPGRGATATLTGRGLAVVAELTADLQPAGWRLTGTHGGSGVDHRRARSLLAQDLDTLEEEAAGLAGAFKIQVAGPWTLAATVEKPRGDKIVSDAGARRELAQALAEGLGDHVRDVRRRLPDVQRLVVQVDEPAIAAVLAGKVPTASGFGRHRSVHPPEAAEALEWVLGAVSAAGAEPWVHTCAPDAPVRLLTGAGARGLSVDLAVATAADHDAVAEALEAGGTVALGVVPASDPPTAPTDAGVTESVLRWLDMVGLDPAEVADRLVVTAGCGFAGATPTWVRRALGLLRTSAASLSG
>NC_008699.1|WP_011756876.1|3650648_3651185_-|type-1-glutamine-amidotransferase
MGDLTGRTVAIIATDHFEEAELVQPRDALRDAGATVLVYSTGTDPIQGVEGDTTPTQKVEVDGTLDDLDVGSVQALVVPGGTVNADRIRTEPRAQDIARQAMEDGKPLAVICHGPWLLVSAGLARGRRLTSYPSLADDVRNAGGTWTDEEVVVDGNLITSRSPEDLPAFIKALEDALS
>NC_008699.1|WP_011756875.1|3648977_3650570_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MTEVTSTAGAETTAPPGTTRHLGWALVLISVAQLMVVLDGTIVNIALPYIQGDLGISDANLRWVVTGYALAFGSLLLLGGRLGDLYGRRRVFMLGLIVFGIASLLGGLATNEPLLLAARGLQGLGAALASPAALALIATTFPAGPARNRAFGVYAAMSGVGAAVGLLLGGWLTGMDSVLGMDVEGWRLTLLINTPIGVATALLATRFLPESETHPGELDLPGAVTGTLGVLGLVYGISRAGTDGWGDTWTVASLVVGVALIAVFLTLERRVEHPLLPVRVFTNRTRAASFVAMFFAPAAMFAMFFYLSQYIQTVMGYSPIKAGVAFLPFVFGLMAAAGISSNMINRVDPRFLAGIGTLLSAGALFGFSRLPYDTSFPVTAVQGSYATDILPFILMMSFGMGLVFVPLTLTAVHHLRVEDAGIGSGVLNTMQQVGGALGLSLLGTIATQTMDDRSAELFPQLAQAAAQLDPTQAGILQKVAGIEIFTEGATDAFLLGAGLMLLASLVTWVFLNVKHQELATDGPEAPVHVG
>NC_008699.1|WP_011756874.1|3648330_3648978_+|TetR/AcrR-family-transcriptional-regulator
MTPIERPRVEGDREQEILDATLEVLADVGYDRLTMDAVAARAKASKATLYRRWNNKVSLVIEALHSAKGPAELPDTGTLRGDLQGVFCGMGGLVDPQSVATFASVLTAIARDADFAEAFRREVVGPKIAVSQEIWRRARERGEVCAEADLSLLEPALAGIVLHRVFVMGEQPDEDLITRVIDQIILPAATCCAVPATTDPSPSPSHKDSHKEQED
>NC_008699.1|WP_011756873.1|3646043_3648302_-|NAD-dependent-DNA-ligase-LigA
MKRNGFVPSNSVGRRGIPSNSTSSAIASAGGAVVWTGAGAGRVRARPEQVSVGPGTMSCVTDPREEHRLIAEEIEEARWRYYVLDSPTIDDADFDRRMRRLEALEEEFPELRTPDSPTQTVGGAVSTDFTSHPHLRRMESLDNAFSVEEVEAWYARLRRDGVEDPALLCELKVDGLAINLLYEEGRLVRALTRGDGTTGEDVTSNVKTITSVPHRLTGTDEFPVPALVEVRGEVFLPVEAFERLNESLLEAGKAPFANPRNSAAGSLRQKDPRITASRALGMVCHGIGERRGFEPQAQSHAYDALAAWGLPTSDQVRVVSTLKGVEGYIENAGARRHTIVPYEIDGVVVKVDDVALQRRLGSTSRAPRWAIAFKYPPEEVNAKLLEIRVNVGRTGRVTPYAVMEPTKVAGSTVENATLHNFYEVERKDVRPGGPGDPGDTVILRKAGDVIPEILGPVLALRPEGLQPWVPPTTCPSCGTPLVEQKEGDKDRRCPNHEKCPGQLRERVFFVASRNAFDIEGLGYEAAVALLDAEVIANEGDVFDLDAAALLRAPLFTRAPKKDEDGPQLSANGQRLLDNLDKAKQVPLWRVLVALSIRHVGPKAGRALATEFGSMAAIRAATEEQLAAAEGVGPTIAEAVIEWFKEPWHVEIVDKWERAGVTMADERDESTPRTLAGLTVVVTGSLVDFSRDSAKEAILSRGGKAAGSVSKKTDYVVVGENAGSKADKAEQLGVPVLDEAGFKTLLDGGPAAL
>NC_008699.1|WP_011756872.1|3645626_3645929_-|hypothetical-protein
MVVIAFMVVGGILVATIATFALLRGFGQEVSRTEAELHEPGSHSELFPVPPGRDPAVLMGVLRSAGFVAVEETPERLLVACPRPGDAERARHLLDHTYQT
>NC_008699.1|WP_011756871.1|3644275_3645613_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MPTNTRTSAQARAARTRPLARLVGADQQVPLVTGGPVRYANLDIAASAPALQSVADRVAEFLPFYSSVHRGAGYASAVSTAAYETARRTIGAFVGARGDDVVQVVRNTTDALNLLATAVPGDVVHLDVEHHANLLPWQGLGRRARAVTARETVAATLAAVEAELHRAPAALLAVTGASNVTGEILPLADLVGIAHRAGARIAVDGAQLVPHHRVHLERLGVDYLAFSGHKLYAPYGAGVLVGRRDWLDAAPPYLAGGGAVRSVSLEHTSWADAPARHEAGTPNVVGAVALAAACEAIAALPDSELRIHEEGLRDRLLNALEFLEVPTLHLWRGQVEAIGVVTFTVAGYDAELVAQYLSAEHGVGVRDGRFCAHPLLERLNGGRTAVRASLGLGSTTEDVDRLVIGIARLVAQGPAWTYDAQGRPAPDPRPLPPWVTEAGPGAACA
>NC_008699.1|WP_011756881.1|3655265_3656381_-|glutamate-5-kinase
MSLRHEVTEAKRIVVKIGSSSLTTAAGGIDPGRVRDLVDVLAKLRAGGSEVVLVSSGAIAAGLAPLGLRRRPRSLPAQQAAASVGQGLLVHRYNEELARHGVVAGQVLLTVDDVTRRSHYRNAYQTFAKLLELGVLPIVNENDTVATSEIRFGDNDRLAALVAHLVHADLLVLLSDVEGLYDADPAAPGSSMLPDVVSVHDLADVRIGKAGAAGLGTGGMHTKIDAARIATGAGIPVVLTSAERAPAALLGEPVGTLFHATGRRRPTRLLWLAHATEPKGTLLLDAGAVRAVVERRASLLAAGITGVEGTFHAGDPVDIAAPDGTPVARGLVNFDAEELPNLLGRSSHELKRELGAGYEREVVHRDDLVLL
>NC_008699.1|WP_011756882.1|3656399_3657950_-|GTPase-ObgE
MAVPTFVDRVTLHVSAGRGGNGVASVHREKFKPLGGPDGGNGGPGGSVTLRVDPDVTTLLDYHHSPKRRAEHGGHGAGAHRNGAHGADLVLPVPDGTVVSDPQGHLLADLVGPGTELVVAQGGRGGLGNAALASAKRKAPGFALLGEPGDELEIVLELKVVADIGLVGFPSAGKSSLIAAISRARPKIADYPFTTLVPNLGVVSAGDTTFTVADVPGLIEGASEGRGLGHDFLRHIERCAAIVHVVDTASIEPGRNPVDDLDVIENELTRYGGLEDRPRLVALNKVDVPDGRDIAGFVVDELRQRGLRVFEVSAASGEGLRELTFAMAGIVEAARAAKPAVEATRIVLRPPSVDGSDAFTVTATPDGWRVRGEKPERWVRQTDFSNDEAVGFLADRLNRLGVETRLAEMGAEEGDAVLIGDPENAVVFDFKPGVDAAAEILSRRGEDQRFDESRPAARRRRAIEEAMADRAEGETRADVARRLDRPAREDGGAYGPQSYEIGGRDDPDWAEEDLGE
>NC_008699.1|WP_011756883.1|3658047_3658302_-|50S-ribosomal-protein-L27
MAHKKGAASTKNGRDSNSQRLGVKRYGGQVVNAGEIIVRQRGTHFHPGSGVGRGGDDTLFALVAGAVQFGTRRGRRVVNIVPGE
>NC_008699.1|WP_011756884.1|3658333_3658642_-|50S-ribosomal-protein-L21
MYAIVRAGAKQQKVAVGDVIEIDQVETAAGEKVTLPVVLVVDGETVTSDAKKLDKASVTAEVLGGTKGPKIVIQKYKNKTGYKKRQGHRQKYTQVKVTDISL
>NC_008699.1|WP_011756885.1|3658807_3662020_-|Rne/Rng-family-ribonuclease
MPDDLQAGAEPTTDAPEQAPTAEKPAAKKATARKTAAKRTAKKAAAAEPADTLVDAPLLDAPADAGGDAAVEAPAKKTAAKKTAAKKAAAKKAPAKAVAKKSAAKKAAAEPVPAEEAPTPPHGDPLAQPTTEQAGPAAPAVLFQAPESTKPAKKTAKKAAAKKAPAKKAAATAPDEDQAAADSAETAEESARPAKKTAAKKTAAKKTAAKKGGGRKADGSSDQPETATEDEDDETTQPEDAESAETGGEGTGRRRRRRGGRRRRKAGDGDSGSGDAAHAGPGEDAEDASDRSDAAAAEDSGPESGGESGGESSSRRRRRRRRSGEDGGASAEDPEGTVTRVRSRRSAEDEITAVSGSTRLEAKKQRRREGREAGRRRAPIVSEAEFLARRESVDRVMVVRQREDLTQIGVLEDRVLVEHYVARESQTSLIGNVYLGRVQNVLPSMEAAFIDIGKGRNAVLYAGEVNWSALGHKDGQPRKIESVLSSGQSVLVQVTKDPIGHKGARLTSQISLAGRFLVYVPDGTTSGISRKLPDTERTRLKALLKEIVPDSAGVIVRTAAEGASEEELTRDVERLKARWEDIEGKAKGSAPQLLYGEPDLTLKVVRDLFTEDFSKLVIQGEDAWDTVQGYVHHVAPDLEARLERYDPGADGAGGKADVFAEYRIDEQIAKGLDRKVWLPSGGSLIIDRTEAMTVVDVNTGKFTGSGGNLEETVTKNNLEAAEEIVRQLRLRDIGGIIVVDFIDMVLESNRDLVLRRLVECLGRDRTRHQVAEVTSLGLVQMTRKRIGTGLLEAFSETCEHCQGRGVLVHEAPVEPRRAEDDSRRGSGRRGRGGRGRGSDQDAAASAPQKAPSPKDVAAMARPDSADLSTEAATDAATEAAVPEVDEVPPVAAEETPERPTDQPVEAAAPVETPPEPETPAEPEPPKVVTRSRRRSASRPAGTPTTATTATAPAAEPVAEPVVAEPVVAEPAEEAVPEAVGEPVPDPVPEPPKVVTRTRRRSASRPAGPPVTEAPASPASPVAETPPPGAIGSVGVPPVSGVVEPGTAEAETDDVPAIEHVPIKKKGSRKR
>NC_008699.1|WP_011756886.1|3662368_3663079_-|DUF2344-domain-containing-protein
MRDQPEQQAPPVQRLRIRYAKRGRLRFTSHRDFSRAFERAVFRARVPMAYSSGFNPHPRISYAGAAPTGSASEAEYLEIGLAEVRDPATVRAALEEALPDGLDVVEVVEAAGGSLADLLEASHWLLDLEVAPEVTGPAVTTFLAAEAVPVQRMTKKGLRDFDCRAAVIALAAEPHGTGTRLDLVLRHGVPSVRPDDVLAGLTAVSGLEMPGAPLLTRLAQGPLDPTTGEIGDPLGG
>NC_008699.1|WP_011756887.1|3663096_3664287_-|winged-helix-DNA-binding-domain-containing-protein
MREIRDTERRSRLARRHALAPGHRAAGPEAATYAMTVLHATEAPTVYLSLWARADGLTVADVDRALYADRTLVKQLAMRRTLFVFPRDLLPAAWGSASARVARAHRARLAKDVEAAGLAADGEAWVAAAEAATLTRLADGSELSAAQLREELPELEGRLHMSPGKSYGGHVPIAPRLFTQLGVEGSIVRGRNAGHWRTARPQWTLTSTWLGEVPEPAKEREGYAELVGRWLRTFGPGTEADLVWWLGATKGAVRAALADVAAVEVALEGGGAGWLLPDDPLAVDPEPDIEPWAALLPVLDPTVMGWKERSFFLGPHAPALFDANGNAGTTVWWDGRVVGCWVQDPDGLVLLNLLEDVGSDGAAALEVEAARLTAWLGGDRVSTVYPSAAMKQAVAR
>NC_008699.1|WP_041546683.1|3664337_3665543_+|MFS-transporter
MSTPARRTAALVLVGLVLLSFNLRPAAISVGPVLAEVRDAYSMSGATAGLLTSLPVIAFAAFGALAPAAAHRIGIHRVTLLAIVAAIAGLIGRVLTHRESVFLVLSLVALAGMAMANVLLPSLVKLHFPDRIGRVTAIYTTALSVGLTASLVLTVPIADAFGGWRSGLGAWAVLAVLAAVPWLSLIAHDRHLESAPRSIRYVDVARTPLGVAMSLFFGLQSLQAYVVFGWFPQLWRDSGYSATVAGVLAGVVAGMSIPLALWLPNVLARSEDPRRLMFTVIAAYPVGYIGLMVAPYALAPVWAVVVGVAAVTFPLILTLIGLRARTPQGTAALSAFTQSTGYLVAAVGPFLIGVVHDASGGWNLPLLILLLLALPLFALAAYVARPMYVEDQLKRSGSPRT
>NC_008699.1|WP_011756889.1|3665659_3665986_+|hypothetical-protein
MLYNPVVDSLDLDLLSEEPFEVDAQAAHLFKHPHLGLKDVYDVWTSDPLFYPARPPAHWLMVAEVVGRVLVVPIAPSRNGDPTRCRPIGCYEASVELARTYRGDRNDV
>NC_008699.1|WP_011756890.1|3665975_3666206_+|Arc-family-DNA-binding-protein
MTSEMTPDEEYEFYADPANREPVGPPRRRKANLTAPIPVRFPESVLDEVKKRAEADDRSVSSWIRRAVEHELNRSA

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Crispr_ID: NC_008699_27

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_27

3937368-3937453

Orphan

Consensus_repeat	Method
GCGCGAGTTTCATCGGCCGGCCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_27

>merge|NC_008699|27|3937368-3937453|CRISPRCasFinder
GCGCGAGTTTCATCGGCCGGCCGACAAACGTCGTGCTTGGACGATGCAGTTTCATCGTCCAGGCTCGAGTTTCATCGGCCGGCCGA

>NC_008699|27|27|3937368-3937453|CRISPRCasFinder
GCGCGAGTTTCATCGGCCGGCCGA	CAAACGTCGTGCTTGGACGATGCAGTTTCATCGTCCAG
GCTCGAGTTTCATCGGCCGGCCGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011757147.1\|3944233_3944893_-\|trimeric-intracellular-cation-channel-family-protein	unknown	unknown	gnl\|CDD\|225415
NC_008699.1\|WP_011757143.1\|3940855_3941422_+\|mismatch-specific-DNA-glycosylase	unknown	unknown	gnl\|CDD\|381679
NC_008699.1\|WP_049774418.1\|3928286_3928850_+\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|377233
NC_008699.1\|WP_011757134.1\|3930068_3931157_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|179564
NC_008699.1\|WP_011757136.1\|3932413_3933763_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_008699.1\|WP_011757144.1\|3941459_3942380_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|223528
NC_008699.1\|WP_011757148.1\|3945031_3946279_-\|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234846
NC_008699.1\|WP_011757130.1\|3926043_3926886_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|181139
NC_008699.1\|WP_140403889.1\|3926895_3928248_-\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NC_008699.1\|WP_140403890.1\|3935259_3936561_-\|site-specific-DNA-methyltransferase	unknown	unknown	gnl\|CDD\|225100
NC_008699.1\|WP_011757137.1\|3933844_3935263_+\|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	unknown	unknown	gnl\|CDD\|274360
NC_008699.1\|WP_011757135.1\|3931153_3932254_-\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|226614
NC_008699.1\|WP_140403892.1\|3942389_3942785_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011757141.1\|3939105_3940368_+\|phosphodiester-glycosidase-family-protein	unknown	unknown	gnl\|CDD\|378342
NC_008699.1\|WP_049774419.1\|3936519_3937362_+\|matrixin-family-metalloprotease	unknown	unknown	gnl\|CDD\|239806
NC_008699.1\|WP_011757149.1\|3946331_3947525_+\|glycogen-synthase	unknown	unknown	gnl\|CDD\|273997
NC_008699.1\|WP_011757142.1\|3940349_3940799_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011757146.1\|3942923_3944237_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|349914
NC_008699.1\|WP_011757133.1\|3928869_3930000_+\|glutamate--cysteine-ligase	unknown	unknown	gnl\|CDD\|237408
NC_008699.1\|WP_041548012.1\|3937553_3939086_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|334820

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011757143.1\|3940855_3941422_+\|mismatch-specific-DNA-glycosylase	gnl\|CDD\|381679	cd10028, UDG-F2_TDG_MUG, Uracil DNA glycosylase family 2, includes thymine DNA glycosylase, mismatch-specific uracil DNA glycosylase and similar proteins. Uracil DNA glycosylase family 2 consists of thymine DNA glycosylase (TDG), which removes uracil and thymine from G:U and G:T mismatches in double-stranded DNA. It includes mismatch-specific uracil DNA glycosylase (MUG), the prokaryotic homolog of TDG. Escherichia coli MUG is highly specific to G:U mismatches but also repairs G:T mismatches at high enzyme concentration. Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Uracil in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other..	2.52826e-62
NC_008699.1\|WP_049774418.1\|3928286_3928850_+\|DUF402-domain-containing-protein	gnl\|CDD\|377233	pfam04167, DUF402, Protein of unknown function (DUF402). Family member FomD is a predicted protein from a fosfomycin biosynthesis gene cluster in Streptomyces wedmorensis. Its function is unknown.	9.35036e-11
NC_008699.1\|WP_011757134.1\|3930068_3931157_-\|DNA-polymerase-IV	gnl\|CDD\|179564	PRK03352, PRK03352, DNA polymerase IV; Validated.	0
NC_008699.1\|WP_011757136.1\|3932413_3933763_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.48749e-105
NC_008699.1\|WP_011757144.1\|3941459_3942380_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	4.65939e-23
NC_008699.1\|WP_011757148.1\|3945031_3946279_-\|glucose-1-phosphate-adenylyltransferase	gnl\|CDD\|234846	PRK00844, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
NC_008699.1\|WP_011757130.1\|3926043_3926886_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|181139	PRK07832, PRK07832, SDR family oxidoreductase.	1.93638e-61
NC_008699.1\|WP_140403889.1\|3926895_3928248_-\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	2.44326e-62
NC_008699.1\|WP_140403890.1\|3935259_3936561_-\|site-specific-DNA-methyltransferase	gnl\|CDD\|225100	COG2189, COG2189, Adenine specific DNA methylase Mod [DNA replication, recombination, and repair].	5.28602e-36
NC_008699.1\|WP_011757137.1\|3933844_3935263_+\|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	gnl\|CDD\|274360	TIGR02946, Putative_diacyglycerol_O-acyltransferase_Mb3115, acyltransferase, WS/DGAT/MGAT. This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity].	1.51368e-147
NC_008699.1\|WP_011757135.1\|3931153_3932254_-\|FUSC-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	3.59861e-23
NC_008699.1\|WP_011757147.1\|3944233_3944893_-\|trimeric-intracellular-cation-channel-family-protein	gnl\|CDD\|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	3.84312e-44
NC_008699.1\|WP_011757141.1\|3939105_3940368_+\|phosphodiester-glycosidase-family-protein	gnl\|CDD\|378342	pfam09992, NAGPA, Phosphodiester glycosidase. This is a family conserved from bacteria to humans. The structure of a member from Bacteroides has been crystallized and modelled onto the luminal region of the human member of the family, the transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. There is some conservation of potentially functional residues, implying that in the bacterial members this family acts in some way as a phosphodiester glycosidase. The human protein is also present, so the eukaryotic members are likely to be catalyzing the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides.	2.28131e-30
NC_008699.1\|WP_049774419.1\|3936519_3937362_+\|matrixin-family-metalloprotease	gnl\|CDD\|239806	cd04279, ZnMc_MMP_like_1, Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.	2.65376e-06
NC_008699.1\|WP_011757149.1\|3946331_3947525_+\|glycogen-synthase	gnl\|CDD\|273997	TIGR02149, glgA_Coryne, glycogen synthase, Corynebacterium family. This model describes Corynebacterium glutamicum GlgA and closely related proteins in several other species. This enzyme is required for glycogen biosynthesis and appears to replace the distantly related TIGR02095 family of ADP-glucose type glycogen synthase in Corynebacterium glutamicum, Mycobacterium tuberculosis, Bifidobacterium longum, and Streptomyces coelicolor. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	4.21187e-180
NC_008699.1\|WP_011757146.1\|3942923_3944237_-\|amidohydrolase	gnl\|CDD\|349914	cd05664, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, Uncharacterized subfamily of proteins predicted as putative amidohydrolases or hippurate hydrolases. These are a class of zinc binding homodimeric enzymes involved in the hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as in the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	0
NC_008699.1\|WP_011757133.1\|3928869_3930000_+\|glutamate--cysteine-ligase	gnl\|CDD\|237408	PRK13517, PRK13517, glutamate--cysteine ligase.	0
NC_008699.1\|WP_041548012.1\|3937553_3939086_+\|hypothetical-protein	gnl\|CDD\|334820	pfam02129, Peptidase_S15, X-Pro dipeptidyl-peptidase (S15 family).	1.58928e-08

>NC_008699.1|WP_049774419.1|3936519_3937362_+|matrixin-family-metalloprotease
MFRMLSAQLARRRHARELRRLLRDLDRLERRRRRTHRIAPRARTSVSLLLAVALAALVVAFNPTSTGERLRATLGIGQDLTFTITDTGGAGYTFAMLQPDGVGPVTWDRCREIPYVVNPEGAPAGHLETVAAAAEDLADASGLRFRYDGTTDDRRLEDRAGPFGSTAPVLVAWATPEEVPALAGDVAGVGGAEARPVTPDRLAFVTGMVALDRDAFAAMAARPDGAALQRAVVEHELAHVLGLGHVDDPAQLMYAETTGQRRLAPGDRDGLAVLGSGPCQ
>NC_008699.1|WP_140403890.1|3935259_3936561_-|site-specific-DNA-methyltransferase
MAAPRQLCREHAEHAAILGPPRACRGRFAHLRARLRHYCRAVGQPWNVFVEGDNLDVLPRVPELVGRPVDLVYIDPPYNTGNDFAYHDDFRCHAAWVEMMRPRLTAAREVLAETGAIFVSIDDHEVAHLRLLMDEVYGEQNLLAQVVVNLNPKGRQLGRGFATSHEYLLVYARDARRTVLDAATHETVDPSDFPLESADGRRYRQLPLRNTNKKFNPVTARTLHFTVWGDPQTGRVATVPFEGAVEIGPVFGDGTPAVWRWSRPLIDQRPDDLVCRRVKGRLGERVDVFQKDWLHPVAAGGVPGVRRKKLRTIWLAEEVGSTDTAVAELKEVVGHVFESPKPTGLLRRILGTMPGDAVVLDFFAGSGTTGHAVALQNAADGGTRRCVSINSAEPTREGSNARNAGLRTVADITRARLRAVAERVGGGFEEVRL
>NC_008699.1|WP_011757137.1|3933844_3935263_+|wax-ester/triacylglycerol-synthase-family-O-acyltransferase
MVSPIDPTATGFLLAENRSMPMHVGGLQLFEKPEGAGRDYGRVMYEAMRDVSEVAPLFIKRPHRSVATAGQLVWVEDEQFDIEHHVRHSALPKPGRIRELLDLAGRLHSTRLAWERPLWEAHVIEGLRDGRVALYTKTHHALVDGISAMRLLQGVLTTDPDQRDMPAPWDAGTRRNQAAAAAGGSSPGLAELPAHVVRQALSQGLGIAAEAAGLPGALVRTLSKGVRNETSAISLHAPRTLFNQKITGSRRFAAQDWPIERLRAIGKATGTTINDVVLAMCSGAVRAYLLEHEALPEAPLVAMVPVGLKAKESNIASIDGGNAIGAVMCRLGTDLVDPADRLRAIHRSMKDGKDALSSMTPTQILVMSALGQAPAIVAPMLRMQGIVRPPYNLIISNVPGPRTTHYWNGARLVGTYPLSIPINGMALNITCTSYDGNMAFGLIGCRRTVPHLQRLLTHLDDEVRALEKAAGV
>NC_008699.1|WP_011757136.1|3932413_3933763_+|serine/threonine-protein-kinase
MDKGDLLGGRYRLTERIGAGGMGTVYRAHDTRLDRTVAIKTLHEGRDVDDVTRSRLRAEAQLAGTLRHPGVVQVFDYGEEAGATGPTPYVVMELVEGTPLSQVLRARGPLPTEEAAALVGDVARALEAAHAAGIVHRDLKPSNILVTPEGRAVLLDFGVARSDSMEPLTETGLIIGSADYLSPEQVRGQRATPASDVFGLGVVAHQSLSAASPFHRDTQAATVLARLHEDAPELPASVPAPLRRLVASMLAREPDDRPSAADVADRAATAHRSGPVLPPPLPTPPSAPRSRWNRQRLLAIAAAAVVLASSLGLLALQRRDVPPAGASELEVPAVVGKRAERAVRILEHAGFEAILEDTTGGVPGQVVRQSPEPGPYDGAATVTLWVVVVPTSAVPPSPMPTPATRPQPHEKPTAIRQNPKEHGPGSAQGQGWENGHGKGPHEEPGKKHD
>NC_008699.1|WP_011757135.1|3931153_3932254_-|FUSC-family-protein
MEAGPLDRMWDRSRTSVRARIRRLQAKSFQIAQCALAAAVAWLIAADVLGHPTPFFAPVAAVVALGTSYGQRLRRVAEVTIGVAVGVFLADLLVVWLGSGWWQIGLIVALAMAAAFLLDGGQLFVTQAAVQSIVVASLVPDPGAAFTRWTDAVVGGAVALVAATAVPAAPLRRPREQAAVVMRKIAALLRAAGEVMDDGEAARALDLLADARSTDYLIRELKDAADEGLSVVESSPFRIRHKGDLRKMVDLVDPLDRALRSTRVLVRHTAVAAYRRRPVPSSYSLLALDLADAADRVADELAANRMAAAARGVLLVVGEATGQVERTDLLTAEAILAQLRAVVADLLMVTGLDQMESTEALPPPPR
>NC_008699.1|WP_011757134.1|3930068_3931157_-|DNA-polymerase-IV
MSGRTAPGWVLHVDLDQFIAAVEVLRRPELAGRPVVVGGRGDPTERGVVATASYEARAFGVGSGMPLRVAARKCPDAVFLPVDKEAYDAASAQVMTTLRGLEWGGVPVVLEVLGWDEAFLAAGEDHGELGNPREFAEHLRAEVLAETRLHCSVGIGDNKLRAKIATDFGKPRGVWQLTEADWFPVMGERPTTALWGIGARTAKKLSALGIDTVEQLARSDARVLAAELGPTMGPWFHRLGRGVDTSPVDATPWVPRAHGREETYQEDLEDWDRVTEEVRALTRRVVDDIDREGRPAARVGIKVRYRPFSTVSRSLTLPEPSNDPAVLEDAAVSLLERVERGRPVRLLGVRLEMVDPPEGPLR
>NC_008699.1|WP_011757133.1|3928869_3930000_+|glutamate--cysteine-ligase
MRIDFHASPEPTLGVEWEFALVDRRTRDLRNDATHLFARAKPRLPDPDKLHKELLRNTVEVVSGVCHTVGEAMADLRRTLEVVVPAGDDLDLDLYGGGTHPFASWTVQQLSEGHRYEELINRTQWWGRQMLIWGVHVHVGMPERDRVMAVLSSLLNFHPHLQALSASSPIWSGIDTGYASNRALMFQQLPTAGLPFQFERWSEFEAFVGDELVTGVIEELSEVRWDVRPAPRIGTLENRICDGVPDLADLSSLVALMHCLVVDLDTRAAAGETLPTMPPWHVQENKWRAARYGLDAIVITDAESNERLVTEDLADHLERLAPVADRLGCSEELAQVAQIPVRGASYQRQRAVAERTGGDLVAVVDSVVRELRAGLG
>NC_008699.1|WP_049774418.1|3928286_3928850_+|DUF402-domain-containing-protein
MTSVARPDLPPRPGDRVRVVMTKWRDGRHWEFEADYLGRDQHGDWLGILAGTPMARPGATYVAPTDQVGLVPAPGPDTGRGWLATFHAVGGPVRVYVDVTTPPVWDGPVVRAVDLDLDVVRGNSGRVWVDDEDEFADHRVRLGYPDELVRAALASCELVRAAIETAAAPYDGTAEAWLTLVGARRGP
>NC_008699.1|WP_140403889.1|3926895_3928248_-|threonine/serine-exporter-family-protein
MPEARQLNLTLDFCLRVGELLLSSGAGAADVTATMQSLAWHLGVRHPEIDITFTSLSMSYQRDPEEPAAVLLRHVKQRDIDYEDLTLVDHLVRDVLRGEVDLKEARSRLARIVSSGHLTPRWAVTLGWGAMCAGVGLQLGGGPVIVAVAFVAAACIDRLQLLMARRRLPFFYQQVAGGGVATIIAVLAAVALPGDLDPSVAVTANIIMLLAGIGFMGALHDALSGFYVTAGARLTEALLATAGIIAGVSGGLTLAEVLGVDVGRLDPGAAADLKTLSVMALGAAICGSAFAFASYAPRRSLLPIGAVAAVAIVISGSGALGGLGRTWPTALAAFFVGLVSYTVAGRMRVPPLVVVVPAIVPMLPGLSIYRGLSLLTEGGGQTSDGLLAIITAASVAIALASGVILGEYVAQPLKREAHRLESRLAGPRLVGPLRTRTSRRARRGAKDRDE
>NC_008699.1|WP_011757130.1|3926043_3926886_+|SDR-family-NAD(P)-dependent-oxidoreductase
MRTLDDKVCVVTGAGSGIGRALALNLAGRGARLALSDVDDIGLAATVDQVRAAGGREVRSDHLDVADRDAFASYAADVAGHFGRVNVAINNAGVALAGNFEDLEYPDMDWIIGVNFWGVVHGTKEFLPHLIASGDGHLVNISSLFGLVSMPGQSMYNASKYAVRGMSEAVREEMLIAGHPVGVTVVHPGGIKTAIARNARVSSREDKEKTARLFDEKLAKMTPERAAEIIVRGILHNRARVLVGLDAHAVHHLAKLTGSRYQDILAKAAGRVLPDQTTAV
>NC_008699.1|WP_041548012.1|3937553_3939086_+|hypothetical-protein
MAAGLAATMAAGTLLAAPVTPAAVAKPVATTTDGCLSSVPDPGTTAPVQICYTVFRPAGASRRHPVPMLMHSHGWGGSRATEPAELSTYLEAGYGVLSFDQRGFGESGGHAYVENPAVEGHDVRALVRLVGRLPWVRQDGPGDPRMGAIGGSYGGGYQFLTAFEELRVTGKPVLDALAPEITWNDLSDSLAPDGVVRTAWAVALSAGAVPSDALPPNVYKALVEGAATGFWPDGSVPGTEDMATFFRANGPKWHVEHGRWLDIPVLLGQGTTDSLFPLQQGLANWRTALTPQARRHSIFVAYNGGHVLPAVLPSGVSVDSDPCSRQLAGGSFADLTVRFFDEQLRGRDTGLHGYGKYHLATPDSTCTTVASVAANTSYDVGTVATPETGGAPLAYEVAAGPIRVAGTPYLTGTLTALGANNRAFYGLAVGTSPADAHLVQNNVLPLNTLEPVVGQPWHLALPSVAVDVPAGQSLYVIASPLSDTFVGMGSRTPGAVLLEDTVAHLPIVGR
>NC_008699.1|WP_011757141.1|3939105_3940368_+|phosphodiester-glycosidase-family-protein
MRTRLLSVSLAACLLAATGPALAGDPGSDASAAGQAVARGGHGNRPDVPRTLHPQHTSGGEEGEVAAALPSMRRTASQNWRTSWQVAPGVKFTRWSQTDARGPIVAHLLTIDPKTPGLRIDYASMGAVRRVAPVRDILAVDNAVAGVNGDFYDIGHTGAPLGLGKDRQRGLLHAREDGWNKAFFINRHGRAGIGDLPMTARVLYHPKLKVTNLNSPFVMPGGIGIYTPRWGRTAGYGVTQGQTERVRAVTVVNGRVRTNRAKLSHDQPIKGLLFIGRGEGAKVLRKLPKHTRIKVRWSLQGRPQMAISGNNFLVHDGIIRAIDDREMHPRTAVGVDSDTGEVLLLVVDGRQADSRGYTMVELANLMVDLGADEAVNLDGGGSSTMVGKNRRGKVAVLNDPSDGFQRWVANAIEVTYSPPS
>NC_008699.1|WP_011757142.1|3940349_3940799_-|hypothetical-protein
MRRILGTTLLVLALPLGAAACGDDEGVSAIGDPPAPEVTLVSGTAAGGQVADGVTVLDGRAAIRAYAGGFRGPLAGKVASAATGFEVPPDAQLVAAVVAVGCDVPPDVDVVGEGAATTFVPARVPSPRQECFAPVTTVALAAVPQDGGE
>NC_008699.1|WP_011757143.1|3940855_3941422_+|mismatch-specific-DNA-glycosylase
MPRFTRAELESFRDAEVPDLVGPGLKLLFVGINPGLWTAATRTHFAHPANRFYPALLQAGIITEPISPSAGMTDEDRDRLRARGLGITNLVRRATARAAELGDEELRAGGLELVETVRRTTPRVVAIAGITAYRAAFGARRAVLGRQPEPLAGAELWIVPNPSGLNAHETIASLAVAYAEAARAAGVI
>NC_008699.1|WP_011757144.1|3941459_3942380_+|NAD-dependent-epimerase/dehydratase-family-protein
MSESPPTAPPVVVVTGANGLVGSHVCAALAERGATVRAVVRRPGAAPDLADVEEWAGEFGDAGFAAAVTAGASAAVTTVHPMGSDLETQRRVGVEATGTFARAAAAAGVGRLVHLSTAAVYDRSPGRGDVDEASALVGDDANDYAVTKRDTDAVLLAVAGPTRVLLRPPAVLGGGETSVWNTLRPAQLRADEAARHAVPEQTFSWVHVLDLAAFAADLAAGRIANATAPDDGPVAGGCTAVNVAAEPGTARDYFETVTRALGVDATWDDAPAWTGRILAGRAQRWGWTPTVDLATALAEIDAGLRA
>NC_008699.1|WP_140403892.1|3942389_3942785_-|hypothetical-protein
MSAMTSWQRSDLDGLVEIAEPPEGMIQIQLEEVGRHSWKSALFGAVMSAGGGPVYRFVAAAPGGEHAEVEHAGSSDRFPLVPFQDLDDDTDDKWTHLARQRLEELDAELVRAGWHRRPDQGKHWWSLRYEW
>NC_008699.1|WP_011757146.1|3942923_3944237_-|amidohydrolase
MTSEPLTSVLAGLSRVRSWQEECYRDLHAHPELSHQETRTAGVVADRLRQDGCDVHEGVGGTGVVGVLSNGGGPTVLLRADMDALPVREATGVPYASTAVATDADGAVVPVMHACGHDVHVACLLGAVSLLAAARDAWHGTVVAVFQPAEEVADGARGMVDDGLVGLVDGAGVGRPQVALCQHVLPLPTGQVATRVGPTLSAADSMRITVHGRGAHGSMPQASVDPVVLAAMIVVRLQTVISRETQPGEPAVLTVGSLQAGTKSNVIPDHAVIALNVRTYHEHTRTAILDAIRRIVVAECEASGSPRPPEFELFDRFPLTDNDPDVTERVAAAFRRRFGDDAVELPLQTASEDFTDLPNAFAIPYTYWGIGGIDRDLYERARSAGRIAQDVPVNHSAAFAPVLQPTLDTGTTALVTAALEWLAPASIVETPDGVAGR
>NC_008699.1|WP_011757147.1|3944233_3944893_-|trimeric-intracellular-cation-channel-family-protein
MSSESPLLLTLDLTGTFAFALNGAMTAIRVARLDVVGVVTLGMITAIGGGILRDILIGAVPPATFSDWRYLLVAAAGSLVAFGFSRALTGLTTPILVLDAAGLSLFAVTGAAKALNFDVGVAQAVILGVITAVGGGTLRDVMTGVVPVVLRSELYAIPALVAATIVVATDRAGGYGVPAALLAAGTCFAIRMLGVHYRINAPRPPGMIEEPDRTDGGSR
>NC_008699.1|WP_011757148.1|3945031_3946279_-|glucose-1-phosphate-adenylyltransferase
MARISRKNVLVICLAGGEGKRLMPLTADRAKPAVPFAGIYRLIDFALSNVVNSGFLKVVVLTQYKSHSLDRHVTQTWRMSTMLGNYVTPVPAQQRVGKHWYLGSADAIYQSLNLMRDERPDYVVVVGADHVYRMDFYQMVKAHAESGAACTVAAIRQPIELADQFGVIDVHPDDPSRIREFLEKPTDPVGLPDSPGEVLASMGNYVFDADALVEAVTRDATEIGSKHDMGGDIVPAFVRRQQAAVYDYKDNDVAGSTDRDRGYWRDVGTLGSYYAAHMDVVSPLPVFNLYNFDWPIYTSYGPQPPAKLVQGASGDLPGVDEAVLSPGVVVTGGQVQRSVLSPSVRVDTGAEVTGAVLMNGVYVGAGAVVRNAILDKNVVVPPGAQIGVDPEADRARGFVVEDGLTILGKDQAFPT
>NC_008699.1|WP_011757149.1|3946331_3947525_+|glycogen-synthase
MRVDVLSKEYPPEVYGGAGVHVAELVRALRARDDVTAHVHAFGALRDEDRTSSYPDLAELATANAALRTLGVDLTIADGCAGTDLVHSHTWYANLAGHLSSLLYDVPHVVTAHSLEPLRPWKAEQLGGGYAISSWAERTSYEAAAAVIAVSAAMRDDVLASYPRIDADRVHVVHNGIDTEDWRPVADPDRVRGLGVDPDRRSVVFVGRITRQKGLPLFLRACSALPPDVQIVLCAGAPDTPEIMAEVEGLVDGLRASRDGVVWIPEMLPRRDVVALLTAATAFACPSIYEPLGIVNLEAMACETAVVATATGGIPEVVVPGETGLLVPIEQASDGTGTPLDPDRYVSDFAAALLEIVSDPGRAAELGRAGRARAIADFSWAAIAERTVAVYRSALAR

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Crispr_ID: NC_008699_28

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_28

4117162-4117246

Orphan

Consensus_repeat	Method
TCCCCGGTTAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_28

>merge|NC_008699|28|4117162-4117246|CRISPRCasFinder
TCCCCGGTTAACCGGGGAAACCGGAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAACATCCCCGGTGAACCGGGGAAACCG

>NC_008699|28|28|4117162-4117246|CRISPRCasFinder
TCCCCGGTTAACCGGGGAAACCG	GAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAACA
TCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011757337.1\|4113723_4114839_+\|DUF4350-domain-containing-protein	unknown	unknown	gnl\|CDD\|379527
NC_008699.1\|WP_008360994.1\|4111278_4111587_-\|30S-ribosomal-protein-S10	unknown	unknown	gnl\|CDD\|179076
NC_008699.1\|WP_011757331.1\|4108644_4109481_-\|50S-ribosomal-protein-L2	unknown	unknown	gnl\|CDD\|236488
NC_008699.1\|WP_011757336.1\|4113103_4113727_+\|DUF4129-domain-containing-protein	unknown	unknown	gnl\|CDD\|379261
NC_008699.1\|WP_041546776.1\|4126843_4128187_+\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|235917
NC_008699.1\|WP_011757342.1\|4119472_4120846_+\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NC_008699.1\|WP_011757347.1\|4125443_4126190_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NC_008699.1\|WP_011757339.1\|4115844_4117137_+\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NC_008699.1\|WP_011757338.1\|4114835_4115834_+\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NC_008699.1\|WP_041546775.1\|4112153_4113107_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011757332.1\|4109512_4109818_-\|50S-ribosomal-protein-L23	unknown	unknown	gnl\|CDD\|235586
NC_008699.1\|WP_011757346.1\|4124428_4125484_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_008699.1\|WP_011757348.1\|4126352_4126838_+\|GyrI-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|214874
NC_008699.1\|WP_011757340.1\|4117256_4118252_-\|stage-II-sporulation-protein-M	unknown	unknown	gnl\|CDD\|376676
NC_008699.1\|WP_011757345.1\|4123013_4124381_-\|beta-glucosidase	unknown	unknown	gnl\|CDD\|274539
NC_008699.1\|WP_011757333.1\|4109814_4110594_-\|50S-ribosomal-protein-L4	unknown	unknown	gnl\|CDD\|235404
NC_008699.1\|WP_011757334.1\|4110596_4111268_-\|50S-ribosomal-protein-L3	unknown	unknown	gnl\|CDD\|234564
NC_008699.1\|WP_011757341.1\|4118308_4119118_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|224628
NC_008699.1\|WP_011757344.1\|4122045_4122975_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_008699.1\|WP_011757343.1\|4121033_4121996_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011757337.1\|4113723_4114839_+\|DUF4350-domain-containing-protein	gnl\|CDD\|379527	pfam14258, DUF4350, Domain of unknown function (DUF4350). This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length.	2.66257e-05
NC_008699.1\|WP_008360994.1\|4111278_4111587_-\|30S-ribosomal-protein-S10	gnl\|CDD\|179076	PRK00596, rpsJ, 30S ribosomal protein S10; Reviewed.	2.05936e-70
NC_008699.1\|WP_011757331.1\|4108644_4109481_-\|50S-ribosomal-protein-L2	gnl\|CDD\|236488	PRK09374, rplB, 50S ribosomal protein L2; Validated.	0
NC_008699.1\|WP_011757341.1\|4118308_4119118_+\|RDD-family-protein	gnl\|CDD\|224628	COG1714, COG1714, Predicted membrane protein/domain [Function unknown].	4.62452e-14
NC_008699.1\|WP_041546776.1\|4126843_4128187_+\|aspartate-aminotransferase-family-protein	gnl\|CDD\|235917	PRK07046, PRK07046, aminotransferase; Validated.	0
NC_008699.1\|WP_011757347.1\|4125443_4126190_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	6.15218e-66
NC_008699.1\|WP_011757339.1\|4115844_4117137_+\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	6.64655e-49
NC_008699.1\|WP_011757338.1\|4114835_4115834_+\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.51548e-95
NC_008699.1\|WP_011757342.1\|4119472_4120846_+\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	2.20163e-25
NC_008699.1\|WP_011757332.1\|4109512_4109818_-\|50S-ribosomal-protein-L23	gnl\|CDD\|235586	PRK05738, rplW, 50S ribosomal protein L23; Reviewed.	1.62861e-47
NC_008699.1\|WP_011757346.1\|4124428_4125484_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.63788e-105
NC_008699.1\|WP_011757348.1\|4126352_4126838_+\|GyrI-like-domain-containing-protein	gnl\|CDD\|214874	smart00871, AraC_E_bind, Bacterial transcription activator, effector binding domain. This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.	9.84323e-12
NC_008699.1\|WP_011757340.1\|4117256_4118252_-\|stage-II-sporulation-protein-M	gnl\|CDD\|376676	pfam01944, SpoIIM, Stage II sporulation protein M. SpoIIM is on e of four stage II sporulation proteins that is necessary for the forespore inside the mother-cell to be properly internalized through the breakdown of peptidoglycans trapped between the membranes of the septum separating the forespore and the mother-cell. The four proteins working in sequence are SpoIIB, pfam05036, SpoIIM, SpoIIP, pfam07454, and finally SpoIID, pfam08486. D, M and P are in a complex with each other and the complex assembles in a hierarchical manner such that M, which serves as a membrane anchor, recruits P to the septum and P, in turn, recruits D to the septum.	2.99433e-40
NC_008699.1\|WP_011757345.1\|4123013_4124381_-\|beta-glucosidase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	0
NC_008699.1\|WP_011757333.1\|4109814_4110594_-\|50S-ribosomal-protein-L4	gnl\|CDD\|235404	PRK05319, rplD, 50S ribosomal protein L4; Provisional.	3.78152e-96
NC_008699.1\|WP_011757334.1\|4110596_4111268_-\|50S-ribosomal-protein-L3	gnl\|CDD\|234564	PRK00001, rplC, 50S ribosomal protein L3; Validated.	1.18347e-123
NC_008699.1\|WP_011757336.1\|4113103_4113727_+\|DUF4129-domain-containing-protein	gnl\|CDD\|379261	pfam13559, DUF4129, Domain of unknown function (DUF4129). This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif.	4.39001e-06
NC_008699.1\|WP_011757344.1\|4122045_4122975_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.79317e-74
NC_008699.1\|WP_011757343.1\|4121033_4121996_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.76071e-64

>NC_008699.1|WP_011757339.1|4115844_4117137_+|DUF58-domain-containing-protein
MAISGRVPLLLLLGVAAVLLRPGMGTVWLWVLAVALLVAADLLLAPAPERLSFERPAVGTVLLGQPTETRLVACNVSRRRVRGTLRDAWQPSAGATGNRHRLALGPGDRVELRTALLPVRRGDLRALGVTVRLRGPLGLAARQRTRVVDGAVRSLPPFDSRKHLPSRLARLRDLDGRAAVRVRGAGTEFDSLREYVRGDDVRSIDWRASARNRAVVVRTWQPERDRRVVLVLDTSRTSAGRVGDVPRLDSAMDAALLLAALAARAGDRVDFVAGDRRVRARLRSAGARDVAARLQDAMADLEPLIAEADWDSLAGAVTALGRQRALVVLLTPLEPAAVEEGLLPVLPTLTKHHRVVLASVRDPALEQLAAARGTLDEVYDAAAAEQVLGRRRRTAGLLRTLGVDVVDADAEQLPPALADHYLSLKARGLL
>NC_008699.1|WP_011757338.1|4114835_4115834_+|MoxR-family-ATPase
MTDPHHPDHPGRSEAADRDARDRLAAVRTEVAKAVVGQDAAVSGLLVALLCGGHVLMEGVPGVAKTLLVRTLAAALSVDARRVQFTPDLMPGDITGSMVIDGTRGELIFREGPIFTNLLLADEINRTPPKTQSALLEAMEEGQVSVDGVSRPLPRPFLVAATQNPVEYEGTYPLPEAQLDRFLLKVVLPIPERADELEIVRRHAAGFDPRDVPAAGVRAVAGADDITAGRAAVGRVQVTPEVAAYVVDIARATRESPSLSLGVSPRGATALLRSARAWAWLTGRDFVTPDDVKALAHATLVHRLGLRPEAELEGVDVGQVLASALGSVPVPR
>NC_008699.1|WP_011757337.1|4113723_4114839_+|DUF4350-domain-containing-protein
MSGHGLLRQRSTLVVLAGLTLAVVVVLLLGDAGARRGVALDPDNPDPDGARALARVLSDQGVDVTIARGAEALDATEVEDATVLVTSTGLLGESTIARLVEHTAGARLVLAEPGPGTTAALGVDSLPYQVTLDEPRPADCADPTYAGLSVQVDHAVEYPVRGGCFRGEHGALVAEPRPDLVLLGAGELLSNGQVLRADDAAVALRLLGERDHLVWYVPSLDDLVGDDGVSLATLLPRWLRPALWVLALSAFALLLWRARRLGPLATEPLPVVVKAIETTRSRGRLYRKAGDRGHAAEVLRSAARRHAADRLGLDTRADAARLVDDVVRHTGRARDEVAWLLGPGAPPPTTDHDLIALADRLAQLDREVRRP
>NC_008699.1|WP_011757336.1|4113103_4113727_+|DUF4129-domain-containing-protein
MTGPLLAILAEPPLDPSPDEAGSLLRRELVRPEYHDRDVLQQVLDWVDRLVSSAVDAASRTPPLSTFAAMVAFLLLALGLGWLVSRARRTARSTRERAVLPAGAVLRADDLRARAERALAEGRAEDAVVDAFRALAVRQVERGVLEDRPGATAHEVATALGAAHPDQRPRVDGTAALFDAVRYGDRPASPAQARGVLELDDVLGGRG
>NC_008699.1|WP_041546775.1|4112153_4113107_+|hypothetical-protein
MLGAAHKPGAMPLRPLALGDMYDAAFRIIRFNPKATVGSAVLVAAVAMGVPVLVTALLTLVVDLSAAQSGDDLSTAEVVGYAGSIGSLFLGTALQSVGSILVTGMVAHVTAAAAIGRRLTLGEAWAATRGSRWRLVGLTLLLGLMLAGLLLAYGLLWILAVVLLPTWAIVLFGVLSVPAFLAFACWFWIRVYYLPVPALMIERTRVLAAIGRGFRLTRRQFWRTFGIALLTVIVTGIAGSMLSAPFTIAAQLLPLAMAESRYAVLVLVVLSAIATVVQTAFVTPFTSAVTSVQYLDQRIRKEAYDVELMTQAGITAS
>NC_008699.1|WP_008360994.1|4111278_4111587_-|30S-ribosomal-protein-S10
MAGQKIRIRLKAYDHEVIDTSARKIVDTVTRTGAKVAGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDIIDPTPKTVDSLMRLDLPAGVDIEIKL
>NC_008699.1|WP_011757334.1|4110596_4111268_-|50S-ribosomal-protein-L3
MTIERNMKGLLGTKLGMTQVWDENNRVVPVTVIAAGTNVVTQVRTPATDGYNAIQVGYGEIDGRKVTKPQAGHFGKAGTTPRRHLVEIRTALAADYTVGQELAVDTFAAGEEIDVTGTSKGKGFAGTMKRHGFAGVSASHGAHRNHRKPGSIGACATPGRVFKGVRMAGRMGTDTVTTQNVTVHAVDTAKGLILLKGAVPGPKGGLVVLRSAAKSSLTSGKEV
>NC_008699.1|WP_011757333.1|4109814_4110594_-|50S-ribosomal-protein-L4
MAEDNEKTTPAKKTAAKKTDAAKTTAAKKAAPAKKAAPAKKAAPAKKAAAPKAAKVDFPAEIFDVELNVPLIHQVVVAQQAAARQGTHATKTRGEVRGGGRKPYKQKGTGRARQGSTRAPQFAGGGTVHGPQPRSYDQRTPKKMKVAALRGALSDRARNDRIHVVESLITAEAPSTRTALAALSTLSERSRFLVVLERTDTVTWLSLRNAPEVHIVAVDQLNTYDVLASDDVVFTQGAYDAFVNGTAVSKPVPAEEAAK
>NC_008699.1|WP_011757332.1|4109512_4109818_-|50S-ribosomal-protein-L23
MSTLHKDHRDILLAPVVSEKSYGLLDANKYTFLVHPDANKTEIKIAVEKVFNVKVTSVNTINRPGKTRRTRNGLGKRKDTKRAIVSLAEGDRIDIFGGPVS
>NC_008699.1|WP_011757331.1|4108644_4109481_-|50S-ribosomal-protein-L2
MAIRKYKPTTPGRRGSSVADFVEITRTTPEKSLTRPLPKKGGRNNQGRITTRHQGGGHKRAYRLIDFRRYDKDGVPAKVAHIEYDPNRTARIALLHYVDGEKRYIIAPKDLTQGTRVESGPNADIKPGNNLPLRNIPVGTTIHCVELRPGGGAKIARSAGNSAQLVAREGSRATLRMPSGEMRFVDVRCRATVGEVGNAEQSNINWGKAGRMRWKGKRPTVRGVVMNPVDHPHGGGEGKTSGGRHPVSPWGQPEGRTRKRKASDSQIIRRRKTGKNKR
>NC_008699.1|WP_011757340.1|4117256_4118252_-|stage-II-sporulation-protein-M
MDLDAYVGAHASEWRRLEELTRKHRLTGAEADELVERYQRVATHLSVVRTSAPDATVVAHLSALLSRARNRATGTRTSTWRGVRLFFVDRFPAALYRLRWWWLGTLAANVAVTAVMMLWLLDHPAVEQSLLSPEQVDQLVAHDFEDYYSEYAASHFAAQVWVNNAWVAALCLALGVLGVPVVYLLFQNIANLAIIGSIMIRHDHGAHFWGLILPHGLLELTAVFVAGGVGLRLFWSWVEPGPLTRTQALAREGRTAGTVALGLVAVLLVSGLIEAFVTPSGLPTWARVGIGVLAEAVFLSYVFVLGRDAVRRGHTGDLDPALLEDRVTSEA
>NC_008699.1|WP_011757341.1|4118308_4119118_+|RDD-family-protein
MAPPEFATLTTDDLVTGEAVALDLPPAGLGLRIASGLVDVLVTAGVLVALVLGLVIAALQADEALLQVAMLAAVIVAFVGFPTALETLSGGRSLGKLAFGLRTVRDDAGPISFQHAFVRALVGVVEIYLFFGGPAFFSALLSVRGKRLGDFAAGTYVVRERVKLQLGPPAAMPPQLARWAAGADLAALPTGLALAVRQFLARLPQIDPASRASIGGRLAAAVEEYVAPAPPAGTPPEAFLAAVVAARRDRDAARLARQAELRRRLTRDR
>NC_008699.1|WP_011757342.1|4119472_4120846_+|carbohydrate-ABC-transporter-substrate-binding-protein
MRSRKTRRGMAVAAALVSAGLVLAGCGGSDDGGSGEASGKSPGEGKAECEQLTQFGDLTGKDVTVYTSIVAPEDKPHIDSWKVFEDCTGADVKYEGSKEFETQLQVRVQSGNPPDIAYVPQPGLLQTLVGTGKVVEAPDTVSANVDKWFGEDWRSYGSVDGKLYAAPLGANVKSFVWYSPKMFAENGWEIPTTWDDMLALSDTITATGIKPWCAGIESGEATGWPATDWLEDVLLRSVGPDVYDQWVAHEIPFNDPAVVESLDNVGAILKNDKYVNGGIGDVSSIATTAFQDGGLPILDGKCALHRQASFYAANWPEGTDVSENGDVFAFYLPAMGDEFGNPVLGGGEFVAAFSDAIEVQAFQTYLSSDQWANEKAKATPNGGWVSANKGLDIANLASPVDKLSGEILQDPDAVFRFDGSDMMPGEVGAGSFWKEMTNWITGESTQDALDKIEASWP
>NC_008699.1|WP_011757343.1|4121033_4121996_+|sugar-ABC-transporter-permease
MSTGEKFIQMVIAIAVFFAVVAVILLLTQRLRSRRGELVQSAAFVLPAIALIGVGLLYPAVTTIYQSFLDRTGDAGVGFDNYKTIFTDADQLIVLRNTAAWVILVPILSTVIGLVYAVLVDRSRFEKVAKALIFLPMAISLVGASIIWRFVYDYHDKSQTQIGIANAVLKGLGFDTYKFILNDPWNTVFLIVVMIWVQAGFAMVILSASIKAIPDDIVEAARLDGVGGFRMFRYITVPSIRPSLIVVLTTISITTLKAFDIVRTMTGGNFDTSVLAYQFYREYFVSANQGLATAIATLIFVLVMPIVIYNVRQMRKLEAR
>NC_008699.1|WP_011757344.1|4122045_4122975_+|carbohydrate-ABC-transporter-permease
MSTAVPEQKGVEAVVAQEPVTATAKRALSSPWASLAAIIIAVLWTIPTFGLLVTSFRPESAITTSGWWTALWNGGWTLDNYDQVLNGSDTNLGTYFVNSLVITVPSVLIPISIAVMAAYAFAWMKFPGRDFLFVAIFALQIVPIQVTMIPLLKLYVNQGFAGSEAPGGGFYTIWLSHSIFALPLAIYLLHNFMSQIPGELIESARVDGAAHVQIFTRIMLPLMAPAIAAFGIFQFLWVWNDLLVALVFGGGSLEISPLTVRLAELSGTRGNDWFLLSAGAFVSLVIPLIVFLSLQRYFVRGLLAGSVKG
>NC_008699.1|WP_011757345.1|4123013_4124381_-|beta-glucosidase
MSLHLPSPSTLAYGAATASYQIEGATAEDGRGASIWDTFTTRPGAIRDGSDGSVACDSYHRYEEDADLVAGLGVGWYRFSIAWPRVLPEGTGRVEPRGLDYYDRLVDALLARGVSPTATLYHWDLPQALEDRGGWLERSTAEAFADYAMVVHERLGDRVGVWATHNEPWCAAYLGYAAGIHAPGRREGGAAHRAAHHLLLGHGLAAARLHEAGVGDVGIALNLAPFWPESPDAVAAADGVDAIRNRLWLGPLVDGAYDDGLLAVAPELADPDVVHEGDLELVRGSADWIGINYYTPFRPTLADPALETHPEVDAYPGATPVSFVVREPRTDIGWEVEARGLEELLVETHRRTGLPLIVTENGAAYADDTLREGAAGVIDDQDRIAYLRDHIAATERARSAGADVRAYIVWTLLDNFEWAEGYTKTFGVVHVDPKDQTRTPKASYHWLAEHVAEAH
>NC_008699.1|WP_011757346.1|4124428_4125484_+|LacI-family-DNA-binding-transcriptional-regulator
MTGIKDVAREVEMSTATVSRALRGLPGVSEETRSRVRETARRLGYVPSPSAAGLASGQTRTVAVIVPFVTRWFFAAVVQGAEEVLRERGYDLLLYNLAGDPSARHRVFETSLLTKRVDAVIVLSLKPSPDERARLEKLGRPVTIVGADLPGWATVRIDDHLAAQTAMRHLLDLGHERIGYVGGATEGVLDFTAPTARLAGYRDSLVEAGHALAPALEANGEFTVTGGMRAGRELLQRPDRPTAVFAASDEMAIGVLRAARELGLAVPEELSVIGIDDHEMAAIFDLTTVAQPVHEQGRVAALQVLGALGRRDWEPEQVLLPTRLVVRRTTAAPAPRPGPSARRRGGGRRGR
>NC_008699.1|WP_011757347.1|4125443_4126190_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MPEHAPDGVRPARPHHKLTADGRRMREVLTYSRRGSRFSPRQQQAWAAYAERWWVPDEAVDDPGFTLAGCFERSAPLIVEIGSGIGESTVALAAARPDHDVVAIEVWRPGVADTLGRIGAAGLSNVRLLSVDAVWSMAHLVEPDSLAALWTFFPDPWHKAKHHKRRLVTASFARLVAGRLAPGAEWRLATDWADYADQMVEVLDAEPMLEGGVVERWAERPVTKFERKGIAAGRAITDLAYRRRGAAR
>NC_008699.1|WP_011757348.1|4126352_4126838_+|GyrI-like-domain-containing-protein
MNHTIDDVHEAGRRIAVTSFPWDHEDISELMAASFGTVARYLGRIGVPITGPAVGYYTKQADGRFRVSAGFVVDEAFEGDGTVELTRLPAGRVITTVHIGPYERLTESYDTLQDYAARHHLVLDQEAMWEEYLSGPDVDPEQVHTRVTWPATHANVPVSVH
>NC_008699.1|WP_041546776.1|4126843_4128187_+|aspartate-aminotransferase-family-protein
MLDRHRLAELRTTEEERFVAARPRSAALAARARGPLLAGVPMPWMTRWPGRFPVFFESATGARLVDVDGHEYVDLCLGDTGAMTGHALPQVADALAARARSGITTMLPSADAVWVGEELARRFGLPTWQLAMSATDANRFVLRFARHLTGRPRIAVMDWCYHGTVDETLAVLDGDRVVPRPGALGPQVPVAETTAVVPFNDAEALERRLAVGDVACLLMEPALTNIGIVLPEPGYLEAVREITHRHGVLLVIDETHTLCTGPGGATAAWGLEPDLVVVGKPIGGGVPCAAYGMSAAVADRLSGPMLGHEIDVAGVGGTLTGNALALAAIRATLSTCLREEDFTVAIPLAERFTDGVAGVIAEHRLPWHVQRLGCRAEYWFCPPPRDGAAAAAAVDEELEGFLHLWCLNRGVLLTPFHNMALFSPAHTPADVDRHTEVFGEAVAALLA

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Crispr_ID: NC_008699_29

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_29

4406765-4406909

Orphan

Consensus_repeat	Method
CGGCCCGACCACGTGGACAGCCCACCGCCCACCAGCGCCGAGC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_008699_29

>merge|NC_008699|29|4406765-4406909|CRISPRCasFinder
CGGCCCGACCACGTGGACAGCCCACCGCCCACCAGCGCCGAGCCGCGCCCGCCAACCCCGGGCCGCCAACCCCGGGCCGGCGGTGCCCCATCCACCTCCACCCGGCCCGACCACGTGGACAGCCCACCGCCCACCAGGGCCGAGC

>NC_008699|29|29|4406765-4406909|CRISPRCasFinder
CGGCCCGACCACGTGGACAGCCCACCGCCCACCAGCGCCGAGC	CGCGCCCGCCAACCCCGGGCCGCCAACCCCGGGCCGGCGGTGCCCCATCCACCTCCACC
CGGCCCGACCACGTGGACAGCCCACCGCCCACCAGGGCCGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_140404063.1\|4398045_4398396_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011757603.1\|4413911_4414988_+\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|176192
NC_008699.1\|WP_011757608.1\|4419388_4420342_+\|GDP-mannose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|379835
NC_008699.1\|WP_011757593.1\|4399619_4399931_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_041548167.1\|4400082_4401915_-\|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl\|CDD\|235256
NC_008699.1\|WP_140404071.1\|4412892_4413894_+\|mandelate-racemase	unknown	unknown	gnl\|CDD\|239444
NC_008699.1\|WP_083768231.1\|4403786_4406273_+\|molybdopterin-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|239155
NC_008699.1\|WP_011757598.1\|4406274_4406751_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011757607.1\|4418402_4419383_+\|GDP-mannose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|224014
NC_008699.1\|WP_041546830.1\|4402062_4402395_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_008699.1\|WP_011757604.1\|4414984_4416793_+\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|225922
NC_008699.1\|WP_041546829.1\|4397588_4398056_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_049774449.1\|4402394_4403414_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223732
NC_008699.1\|WP_011757599.1\|4406982_4407990_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235935
NC_008699.1\|WP_011757601.1\|4410985_4412767_+\|thiamine-pyrophosphate-requiring-protein	unknown	unknown	gnl\|CDD\|181344
NC_008699.1\|WP_011757606.1\|4417110_4418364_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379306
NC_008699.1\|WP_011757600.1\|4407986_4410989_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NC_008699.1\|WP_158305695.1\|4403401_4403782_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_008699.1\|WP_011757592.1\|4398408_4399623_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371831
NC_008699.1\|WP_011757605.1\|4416789_4416993_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011757601.1\|4410985_4412767_+\|thiamine-pyrophosphate-requiring-protein	gnl\|CDD\|181344	PRK08273, PRK08273, thiamine pyrophosphate protein; Provisional.	0
NC_008699.1\|WP_011757603.1\|4413911_4414988_+\|glucose-1-dehydrogenase	gnl\|CDD\|176192	cd08230, glucose_DH, Glucose dehydrogenase. Glucose dehydrogenase (GlcDH), a member of the medium chain dehydrogenase/zinc-dependent alcohol dehydrogenase-like family, catalyzes the NADP(+)-dependent oxidation of glucose to gluconate, the first step in the Entner-Doudoroff pathway, an alternative to or substitute for glycolysis or the pentose phosphate pathway. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossman fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.	7.29496e-148
NC_008699.1\|WP_011757608.1\|4419388_4420342_+\|GDP-mannose-4,6-dehydratase	gnl\|CDD\|379835	pfam16363, GDP_Man_Dehyd, GDP-mannose 4,6 dehydratase.	1.0436e-129
NC_008699.1\|WP_041548167.1\|4400082_4401915_-\|phosphoenolpyruvate-carboxykinase-(GTP)	gnl\|CDD\|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NC_008699.1\|WP_083768231.1\|4403786_4406273_+\|molybdopterin-oxidoreductase-family-protein	gnl\|CDD\|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NC_008699.1\|WP_011757607.1\|4418402_4419383_+\|GDP-mannose-4,6-dehydratase	gnl\|CDD\|224014	COG1089, Gmd, GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane].	4.90736e-176
NC_008699.1\|WP_041546830.1\|4402062_4402395_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.92917e-12
NC_008699.1\|WP_011757604.1\|4414984_4416793_+\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	5.30748e-124
NC_008699.1\|WP_049774449.1\|4402394_4403414_+\|STAS-domain-containing-protein	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	1.04833e-46
NC_008699.1\|WP_011757599.1\|4406982_4407990_+\|SDR-family-oxidoreductase	gnl\|CDD\|235935	PRK07109, PRK07109, short chain dehydrogenase; Provisional.	2.66687e-170
NC_008699.1\|WP_011757600.1\|4407986_4410989_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.01459e-70
NC_008699.1\|WP_011757606.1\|4417110_4418364_+\|ATP-binding-protein	gnl\|CDD\|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	2.21099e-45
NC_008699.1\|WP_140404071.1\|4412892_4413894_+\|mandelate-racemase	gnl\|CDD\|239444	cd03328, MR_like_3, Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. This subgroup's function is unknown.	4.76188e-155
NC_008699.1\|WP_158305695.1\|4403401_4403782_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.21881e-20
NC_008699.1\|WP_011757592.1\|4398408_4399623_-\|hypothetical-protein	gnl\|CDD\|371831	pfam11981, DUF3482, Domain of unknown function (DUF3482). This presumed domain is functionally uncharacterized. This domain is found in bacteria and eukaryotes. This domain is typically between 289 to 301 amino acids in length. This domain is found associated with pfam01926. The central region of these proteins contains a hydrophobic region that is similar to pfam05433.	0.00948812

>NC_008699.1|WP_011757598.1|4406274_4406751_+|hypothetical-protein
MPHLATYVGLADHSERTLADSFRAIAEGHAHVADVFHTCRLLAGWCDRHREALAPVIDRYGEQAGDREGVDEPERLHAAGLAQAREGEVGLLRDLQDLHVLASLVQSTWMVIAQGAQGLRDRELLQIAQDSGAEAARQIAWLDTRMKVAAPQALIVAP
>NC_008699.1|WP_083768231.1|4403786_4406273_+|molybdopterin-oxidoreductase-family-protein
MEWTASPTRAREAVTNASATASTGSPAGSSVASIPAIYAQAHESGSAGHRTRVSANTEQASTDRTQDVWGERTPHPRATPWPTRVDLHLEDGLAEDQVDSWVASACLLCSNGCGVDIAVKDGKMVGVRGRETDRVNHGRLGPKGLYGSTPWSHSPDRLTTPLVREHGELVETDWDTAMGRIVARSKQLLEEQGPLSHGFYTSGQLFLEEYYTLAVIGKAGLGTPHMDGNTRLCTATAAAALKESFGADGQPGSYEDIEHCDALFLYGHNMAETQTVLWSRILDRTRGEDPPKVVCVDPRRTAVAAEAERTGGVHLAPKVGTNLALMNALIRELLEHDAWVDHAWVDAHTIGLEGLRAAVAPYTPEQAAEICGVDPDEVRRAARIFGESEAVLSTVLQGFYQSHQATAASVAVNNLHLLRGMIGRPGAGLLQMNGQPTAQNNRETGADGDLTGFRNWDNPTHVQELADHWNVDPMTIPHWAPPTHAMQIFSYAQAGTVGLLWISATNPAVSMPETERIRSILSGDQCFVVVQDLFLTETAQLADVVLPAAGWGEKTGCFTNVDRTVHLSQQAVDPPGEARSDLDIFLAYADAMGFEDQDGGPLITWRTPEETFAHWSAATRGRPCDYTGITYELLSGPTGVQWPLGVERLYADAQFPTHTEQCETFGHDLTTGATVTEQEHRAQAPAGRAFLKGAPYSPPHEEPSAEYPFRLTTGRTVYQFHTRTKTARSRPLDACAPHAWVELAPADSQRLGIADGDLVRLESPRGSVDVPARVTEVTEGAVFVPFHYGDHPANELTMTVWDPVSKQPTFKTAACRVTRLGAGTGEEG
>NC_008699.1|WP_158305695.1|4403401_4403782_-|MarR-family-transcriptional-regulator
MGAPEVTVAQFRLLVLLAASGERTVGDVAEHLGVAQSNASRHCDRLQRLGLVARRRSRSDGRVVRVRLTDEGRALVDAVDRRRRGEVHRLLGRMTPEERSGALEAMRAFSRAADELGERSWVVQAW
>NC_008699.1|WP_049774449.1|4402394_4403414_+|STAS-domain-containing-protein
MGGRTGAGVAELLPQAADWRPFRPGADLTAGLMVGLVALPLALGFGASSGLGAGAGLVTAIVAGAVAALFGGIPATAAIARTAVNVRSGATTRLASLSHSVVLLAVVLVAARWVAEIPLAALAGVLVATAFQMVRLSSVAALLRATRGDAAVLVVTAVATVAVDLVTAVIVGLVVAGFFALRQTALAARLDEVPLEEGTDGPDDTTHADEERRLLDQHIVAYGMEGPLFFAAAHDFLLELSEASDVRVVVLRMSRLSTIDATGASVLADTMARLEGRGITVLLSGLQPRHDKVLRELGVFDRLGHDRHLFATTPEAIAHARQHVAREQHTHDTSEPHHA
>NC_008699.1|WP_041546830.1|4402062_4402395_+|winged-helix-turn-helix-transcriptional-regulator
MGVPLYQAKAELFKTLGHPARIRILELLSERDHAVHELLEQIEIEPSNLSQQLAVLRRTSMVESHRTGSEVVYSVSVPEVRDLLLAARTILSGLIAVQGELGTELAASAS
>NC_008699.1|WP_041548167.1|4400082_4401915_-|phosphoenolpyruvate-carboxykinase-(GTP)
MMDLESVLDAAGLTNPHVREYVARWAAITGAERVEVVDASDDARLVKEALEAGELQPVGDGCYYSRSYSKDTARSEERTIVATNDPADKGTYNNWRPAGEMKELLEGLMRGASTGKTMYVIPYLMAPPGSPMERFAAGVQVTDCRPVVLHMIRMSRVGVHHINDLADPNSFVRAVHVTGDLENLGQGTPDDQRYFVTVADERTILHYGSSYGGNALLGKIAHGLRQAAYDGQASREFLAEQFMLLGIIDNETGQRFHVAGGFPSASGKTNLAMTLAPEALGERYRVEFYGDDITWLWIDSQDGRLYGMNPEFGVFGVAKDTNESTNPTALDSVRPGTGAIFTNVAYNPRTQEVWWEGRTPEPPSDLDGWLDWKGEPIAARAPGDESPWAHPNSRFTTTLANVPNVAADFEEPRGVPIDAIIFGGRTRDREPLVRAITDLAEGVYDGLTLGAEATFAADGVDGQLRYDPMSMRPFMSYPEARYAAHWLDVVGRASDQPIFAHVNWFQRDPEDGHFLWPGYRENLRALLWLARLKEGSVTGVQTAVGILPKEDELHLADLDLPEADKERILSIDKDRWCQEMGFRETHLAQFDGLPEEIWEAHRRVARDLDC
>NC_008699.1|WP_011757593.1|4399619_4399931_-|hypothetical-protein
MGVPEVEVHPDDLSQVVDVLTSAGGALSGHAGDLATGPDAGRSTGEVGRALAALGAAVAALGAELGALASRTGAASGLLTGTDDLIGARLDSHLDGGTGPVGP
>NC_008699.1|WP_011757592.1|4398408_4399623_-|hypothetical-protein
MSDVLDTRVYGDPAACSAAAGAVGGVRRAVADAESAAGKARSLASSWRGQAGAAFEARVDATITDLAGLGERLEAMRSALGDFAGELTVVRDRMAHARAVAAAGGVSVTGTDVHRPVAPEVMSQGQADAFTTRAEAWNEAVGIAEAARTKETEAHDHLRDGLDRTTGDGFLEDLLERLGLLPADFADGDDIGAYLLGLGGLGFGAATGYLVSSRYGIFQPRVAGRFASPAGLDFWGRLRAGASGDSFHARPYTAGARDWWGRAGKVGGYAGTALTGGFAAWNQWQADADDPSLSDANKAGRAGAMGVSTAAGAWAGAEAGAWAGGAIGTAICPGIGTAIGGVAGGLVGGAVGGFVGSEVGQEVMGAVGDATEATVDWVGDAAGDVGDWAGDTGGDVVDAVTFWD
>NC_008699.1|WP_140404063.1|4398045_4398396_-|hypothetical-protein
MVTPVLMLLAGVGLAAWNLWQRRGRTPAARAWARGLQGDWTRRSVLVVRPLIALVLVLGAVVAWREDGALVVAVGAAIGVCLLLLGAFLVLPIPVPGFLEPGWCRESRARGRAHAG
>NC_008699.1|WP_041546829.1|4397588_4398056_-|hypothetical-protein
MPGEGGAGLLDVPAGWEVHDRPAEGALLVVREPAGADPPAFRANLVVTAVPVGGLSFRDWQAGSDEILARALEDYLLVDLERLSVGGRPGGRRLAHHAGPRGEALTLEQWVTLVDGVGHTLTATVATGRYDELADLLATAAASWRPDPLGGTGAR
>NC_008699.1|WP_011757599.1|4406982_4407990_+|SDR-family-oxidoreductase
MTGRVVVVTGASGGIGRACARAFAARGDDVALLARGETGLEAAAAEATDAGVRALPVEVDMADAAAVEAAALRIEAELGPIEVWVNVAFTSVFARFVDIAPEEFARVTEVSYLGYVNGTRSALRRMTARDRGTIVQVGSALAYRGIPLQSAYCGAKHAIQGFHESLRTELLHDGSRVHVTMVQMPAVNTPQFDWVRSRLPRHARPVPPIYQPELAADAVVYAADHPSRREYWVGETTALTLLANAVAPGLLDRYLARTGFKSQQADRRRDPDQPENLWAPADGAAGADFGAHGDFDARSHRRSPQVWASQHHGLLGAAAAGGIALAGALARRRAS
>NC_008699.1|WP_011757600.1|4407986_4410989_+|FAD-binding-oxidoreductase
MTATAVPDLGRAALTLADRVDGEVRFDPGSRAAYSTDASNFRQVPLGVVVPHTIEAAVEAIAVCHELGLPVVSRGGGTSLAGQCTNAAVVLDFSKYCHRLLSVDAANRRCVVEPGIVLDDLNAQLAPTGLRFGPEPATHPNCTLGGMIGNNSCGATAQRTGKVVDNVASLDVLLHDGTRFTAAPLTDEQYAEAAARPGRVGEIHRRLRRLRDDHADLIRERYPDIPRRVSGYNLDSLLSEHGFDVAGFLVGSEATLVTVLRAELELVPVVPARTLVVLGYPGIAAAADAVPSVVEHEPIALEGVDDFLLRDQQLKGMNPEALDMLPRGSGFLMVQMGGADTDESDRRAEAMLAALGRTDHAPDVAFYDDPDREHELWLVRESGLGATAHVPHRPDTFEGWEDAAVPVDRLGDYLRDVRRLYEEFGYASDVGPSLYGHFGQGCVHTRIPFDLYTTEGVATYRRFLERAADLVVSYGGSLSGEHGDGQTRGELLPKMFGAEVVGLFEEVKALFDPDDLMNPGKVVHPAPLDAHLRLGGHWEPKRLLPLAFGFPEDGHSFAQAANRCVGVGKCRQLDHDGGTVMCPSYQATREEQHSTRGRARLLFEMMDGHGDGTITDGWRSTEVREALDLCLACKGCKSDCPAHVDMATYKAEFLYHHYRHRLRPRADYATGWLPTAAMLVDRLRLAPVVNAVAGVRPLRRAGTRLAGLEDREVPRFARQSLQRWLAGHTPAPGAGARGTVLLWPDTFTNHFHPEVGIAAVRVLESAGWGVTMPQRPVCCGLTWISTGQLGVARMRVRHTIAELAPHVRAGGLVLGLEPSCTSVLRSDAVELMPEDRDAKRVRDHTVTLAELLTEHTDGWEPPYAGGVSALAQVHCHQHAVLGWDADRTLLEHAGADVEQLESGCCGLAGNFGFTAGHGEVSAACAEQVLLPRLREVDPRDPATVVLADGFSCRTQIHELDSGGNEGVHLAQLLARLLDGQTATPTDRTARPEERSEGSTR
>NC_008699.1|WP_011757601.1|4410985_4412767_+|thiamine-pyrophosphate-requiring-protein
MTTTVADQLLARLREWGVAQVFGYPGDGINGILGAFSRADDQPRFIQSRHEEMSAFQAVGYAKFSGRPGVCMATSGPGAIHLLNGLYDAKLDHVPVVAIVGQTNRTAMGGSYQQEVDLISLFKDVAGDYVQMVTVPEQLPNVLDRAIRVATARRAPTAIIVPNDVQELEYAAPQHAFKMVPSSLTPTQRPTVTPDPAALRQAADVLNSGRKVALLVGQGARGADAEIAEVVDLLGAGVAKALLGKDVLSDELPWVTGSIGLLGTRPSYELMMGCDTLLTVGSSFPYTQFMPELDQARAVQIDLDGTMIGMRYPYEVNLVGDAQATLRALIPLLEKQQDRSWHDEICANVTDWWEVMDAEAHVAADPVNPMRIFNEFSKVAPTDAIISSDSGSAANWYARHVKMRGRMRGSLSGTLATMGPAVPYAIGAKFAHPDRPAIAFEGDGAMQMNGLAELLTIARYWPEWADPRLVVAVLHNNDLNQVTWELRAMGGTPTFVESQALPDVSYADFARSCGLGATTVTDPDQLADAWQVALSSDRPHLLDVHCDPDVPPIPPHATLEQMTAMAKALIKGDTSRWGVMKEGIRTKAQELLH
>NC_008699.1|WP_140404071.1|4412892_4413894_+|mandelate-racemase
MVVVHARAGGEVGTGWTWAPAAAAAVVDELLSPVVLGRDALAPAAAQEAMLRAVRNAGRGGLVAMAVSAVDIALWDLGARLLDLPLHRWWGDAATPVPVYGSGGFTTYDDDRLRSQVRGWLALGLPAVKIKVGESWGRRERRDLDRTALVRDLVDTTGPGTQVFVDANGGYSPGQARRVGRDLDALGVTWFEEPVSSEDLPGLAAVRAAVDADVAAGEYADDPAAFARLLPVVDCLQVDVTRCGGYTGWRQAVALAAAHGVDVSGHCAPYLTVPVAAVTPRLRHLEWFHDHVRIVRELVEGYADPLGGTLTVADGPGHGLRLRAAAAERYRVA
>NC_008699.1|WP_011757603.1|4413911_4414988_+|glucose-1-dehydrogenase
MRALTVRPGAAGTLAVETVPDPEPAAGELLVAGLAIGVCGTDKEIVRGEYGWAPHDHDGRLVLGHESLGRVLEAPAGSGFAAGDLVAGVVRRPDPEPCGACAHDEWDMCRNGRYTERGIKELDGFGSERWTVPPEYAVRVAGHLGLAGVLMEPTSVVAKAWEQVDRVGARAWFEPRTALVTGAGPIGLLAALIGVQRGLDVHVLDLVTDGPKPDLVRDLGATYHHSSVAEIARTARPDVVLEATGVGRLVFEAMAATSPYGVVCLTGVSSAGRRLSVDAGGLNRELVLENDVVVGSVNANTRHYRAAADALAAADLAWLERLLTRRVPLADAADAFEAGPEDVKVVIELGADDGEGAG
>NC_008699.1|WP_011757604.1|4414984_4416793_+|glycoside-hydrolase-family-15-protein
MSNRIEDYALIGDLQTAALVGRDGSIDWLCLPRFDSAACFAALLHDEGAGHWRIAPAGADSATSRRYREHTLVLETTWETADGTVRVVDLMPPRGEAPDVVRIVEGVSGSVPVEMALRLRFDYGRVRPWTRVDRAEASAIAGPDAVWLSASVPLSHDGDAVRAEFTLAAGDRAWFVLTYQAAHLPRPDPVDAERALADTASYWTDWVDRGSYEGRWAEEVERSLLLLKALTYAPTGGILAAATTSLPEDVGGVRNWDYRYCWLRDATFTLQALLGTGYTEEARAWREWLVRAVAGDPDKLQIMYALDGTQRLPETTLDWLDGFDDSTPVRVGNAAAGQFQLDVWGEVLDGLHLARNAGLELTDPAWDVQRALLDWLEGNWRQPDNGLWEVRGPQRQFVHSKVMAWVGVDRAVRTVERLDLDVPVDRWRRLGQEIHAEVCEHGYDADRRTFTQFYGSEGLDAALLLLPRVGFLPWDDERVVGTVEAVQRELCREGFLLRYDPAADGGADGLPGTEGAFLACSFWLADALHGIGRTGEAEEMFTRLLALRNDVGMLSEECDPRSGAHLGNTPQAFSLVGLVNTARHLGGTTHATTETPTRGDRA
>NC_008699.1|WP_011757605.1|4416789_4416993_+|hypothetical-protein
MTLHPGDPLDDLLRWEQAGGSWRLLDRGGEGVTVSLRRCDGGEEVDRIVSTDPELAVYVTARPSSED
>NC_008699.1|WP_011757606.1|4417110_4418364_+|ATP-binding-protein
MLEYRNRVADDELASRMRAAGAVLIEGPKACGKTATAQRVATTTFRLDVDDGARDLVDAAPELLLGADPPVLFDEWQLAPKLWNLVRREVDDRGIRGQFILTGSATPNDDTSRHPGAGRFSRLRMRPMSLFESGVSTGEVSLGALFNGDFKPSLDPGVTVPKLVDHLIVGGWPGLLEASVRDAQRWLADYLATIVEVDLPQLGVRRDPATLRRLLASLGRGVGTELSTKAIADDVGGADGPARRDTVAGYLRALERLMLIEDVPAWGPHMRSTTPLRKSATRFMTDPSLGLAALGVGPEHLLRDLNATGFHFEGLVARDLRVYAQPLDGQLWHWRDNNGHEVDIVITLADGRWGAIEVKLNPDSVDRAAKSLARFATKVDTSKAGDPAFLAVVTTRTAALRRPSDGIYVLPVATLGP
>NC_008699.1|WP_011757607.1|4418402_4419383_+|GDP-mannose-4,6-dehydratase
MPTALITGITGQDGLYLAEFLLAKGYDVHGVIRGQNNPKRDLVEQLLPDVRLHNGDLTDMSSLIRALRDSCPDEVYNLGAVSFVAYSWENAQLTTDVTAKGVLNMLEAVRLHTGDEPEEIRFYQASSSEMFGKVQEVPQHERTLLWPRSPYGVSKVFGHYMTINYRESYGMHASSGILFNHESPRRGPEFVTRKISEAVARIKLGVQKELVLGNLDAERDWGFAGDYVEAMWLMLQQPAADDYVIATGEAHSIRDFLDAAFAHIGIDDWAPYVRQDPRFMRPAEVDHLIGDASKAREVLGWKPKVSFHELVALMVDADLAATQQGW
>NC_008699.1|WP_011757608.1|4419388_4420342_+|GDP-mannose-4,6-dehydratase
MTRPLRAFVTGISGQDGRYLAERLLGEGVEVHALAHALEPLPDLPGVELHRGDLTAVEEVRALLVDVAPDEVYNLAALSSVARSWEEPDLTARVNGLAAAGLLESALQVQDKLGRPVRFVQASSAEIFGQPDRSPQDESTPLRPVNPYGAAKAYAHLMVDVYRRRDLHAVSAILYNHESPHRPPEFVTRKITSTVAAIAHGRAGTLALGNLDARRDWGWAPDYVDAMVRAVRADVARDYVVATGVSRSVRDFVAAAFARAGIEDWQHLVTVDPEFVRPADPTELVGDATLARETLGWAPTVEFDEIVGRMVDADLAT

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Crispr_ID: NC_008699_30

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_30

4474564-4474649

Orphan

Consensus_repeat	Method
TCGGCCGGCCGATGAAACTCGTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_30

>merge|NC_008699|30|4474564-4474649|CRISPRCasFinder
TCGGCCGGCCGATGAAACTCGTGCCTGGACGATGCAGCTTCATCGTCCAGGGTCGAGATCTGTCGGCCGGCCGATGAAACTCGGCG

>NC_008699|30|30|4474564-4474649|CRISPRCasFinder
TCGGCCGGCCGATGAAACTCGTGC	CTGGACGATGCAGCTTCATCGTCCAGGGTCGAGATCTG
TCGGCCGGCCGATGAAACTCGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011757663.1\|4476072_4476630_-\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|131283
NC_008699.1\|WP_011757661.1\|4474774_4475206_+\|Hsp20-family-protein	unknown	unknown	gnl\|CDD\|365807
NC_008699.1\|WP_140404069.1\|4483137_4483830_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_008699.1\|WP_011757664.1\|4476677_4477190_-\|alternate-type-signal-peptide-domain-containing-protein	unknown	unknown	gnl\|CDD\|274972
NC_008699.1\|WP_140404068.1\|4478507_4478894_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011757657.1\|4472444_4472930_-\|DUF4395-domain-containing-protein	unknown	unknown	gnl\|CDD\|379566
NC_008699.1\|WP_041546850.1\|4469174_4471079_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|185628
NC_008699.1\|WP_011757659.1\|4473824_4474253_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NC_008699.1\|WP_011757670.1\|4482474_4483113_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_008699.1\|WP_011757662.1\|4475261_4476080_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011757656.1\|4471540_4472389_-\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NC_008699.1\|WP_041546849.1\|4468514_4468940_+\|D-tyrosyl-tRNA(Tyr)-deacylase	unknown	unknown	gnl\|CDD\|235383
NC_008699.1\|WP_011757669.1\|4481436_4482297_-\|inositol-phosphorylceramide-synthase	unknown	unknown	gnl\|CDD\|239481
NC_008699.1\|WP_011757651.1\|4466499_4466913_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_193371869.1\|4473252_4473732_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_008699.1\|WP_049774455.1\|4467028_4467871_-\|3-keto-5-aminohexanoate-cleavage-protein	unknown	unknown	gnl\|CDD\|377562
NC_008699.1\|WP_011757655.1\|4471244_4471541_-\|DUF1416-domain-containing-protein	unknown	unknown	gnl\|CDD\|377793
NC_008699.1\|WP_011757668.1\|4478908_4481437_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_008699.1\|WP_011757665.1\|4477394_4477667_-\|MoaD/ThiS-family-protein	unknown	unknown	gnl\|CDD\|340560
NC_008699.1\|WP_011757660.1\|4474229_4474520_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133394

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011757663.1\|4476072_4476630_-\|signal-peptidase-I	gnl\|CDD\|131283	TIGR02228, Signal_peptidase_I_W, signal peptidase I, archaeal type. This model represents signal peptidase I from most archaea, a subunit of the eukaryotic endoplasmic reticulum signal peptidase I complex, and an apparent signal peptidase I from a small number of bacteria. It is related to but does not overlap in hits with TIGR02227, the bacterial and mitochondrial signal peptidase I.	5.61688e-23
NC_008699.1\|WP_011757661.1\|4474774_4475206_+\|Hsp20-family-protein	gnl\|CDD\|365807	pfam00011, HSP20, Hsp20/alpha crystallin family. Not only do small heat-shock-proteins occur in eukaryotes and prokaryotes but they have also now been shown to occur in cyanobacterial phages as well as their bacterial hosts.	2.72181e-25
NC_008699.1\|WP_011757664.1\|4476677_4477190_-\|alternate-type-signal-peptide-domain-containing-protein	gnl\|CDD\|274972	TIGR04089, conserved_hypothetical_protein, alternate signal-mediated exported protein, RER_14450 family. Members of this Actinobacterial protein family contain the cognate signal peptide domain, modeled by TIGR04088, for the variant SipW form of the signal peptidase I family. The remainder of this protein, however, differs from families such as Peptidase_M73 (pfam12389) and YqxM (TIGR04087) that share the same signal peptide domain. Some additional homologs to this family lack full-length homology and are excluded by the trusted cutoff as set. The two known targets for export by the SipW signal peptidase in Bacillus subtilis act in producing biofilm matrix material.	8.5355e-35
NC_008699.1\|WP_011757657.1\|4472444_4472930_-\|DUF4395-domain-containing-protein	gnl\|CDD\|379566	pfam14340, DUF4395, Domain of unknown function (DUF4395). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 142 and 168 amino acids in length. There are two completely conserved C residues that may be functionally important.	1.17084e-37
NC_008699.1\|WP_041546850.1\|4469174_4471079_+\|hypothetical-protein	gnl\|CDD\|185628	PTZ00449, PTZ00449, 104 kDa microneme/rhoptry antigen; Provisional.	9.25568e-06
NC_008699.1\|WP_011757659.1\|4473824_4474253_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	1.90498e-08
NC_008699.1\|WP_011757670.1\|4482474_4483113_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	9.78729e-12
NC_008699.1\|WP_011757656.1\|4471540_4472389_-\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	8.48106e-103
NC_008699.1\|WP_041546849.1\|4468514_4468940_+\|D-tyrosyl-tRNA(Tyr)-deacylase	gnl\|CDD\|235383	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional.	9.94089e-71
NC_008699.1\|WP_140404069.1\|4483137_4483830_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	6.45403e-12
NC_008699.1\|WP_011757669.1\|4481436_4482297_-\|inositol-phosphorylceramide-synthase	gnl\|CDD\|239481	cd03386, PAP2_Aur1_like, PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.	1.63784e-39
NC_008699.1\|WP_193371869.1\|4473252_4473732_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	3.664e-16
NC_008699.1\|WP_049774455.1\|4467028_4467871_-\|3-keto-5-aminohexanoate-cleavage-protein	gnl\|CDD\|377562	pfam05853, BKACE, beta-keto acid cleavage enzyme. BKACE, beta-keto acid cleavage enzyme plays, a role in lysine degradation. In certain instances it catalyzes the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA. The family is found to have at least 14 slightly different potential new enzymatic activities, all of which can therefore be designated as beta-keto acid cleavage enzymes.	8.52017e-111
NC_008699.1\|WP_011757655.1\|4471244_4471541_-\|DUF1416-domain-containing-protein	gnl\|CDD\|377793	pfam07210, DUF1416, Protein of unknown function (DUF1416). This family consists of several hypothetical bacterial proteins of around 100 residues in length. Members of this family appear to be Actinomycete specific. The function of this family is unknown.	4.47178e-39
NC_008699.1\|WP_011757668.1\|4478908_4481437_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	4.00108e-107
NC_008699.1\|WP_011757665.1\|4477394_4477667_-\|MoaD/ThiS-family-protein	gnl\|CDD\|340560	cd17040, Ubl_MoaD_like, ubiquitin-like (Ubl) domain found in a group of small sulfide carrier proteins. Ubiquitin-like (Ubl) domain found in a group of small sulfide carrier proteins This family includes ThiS, MoaD, CysO, QbsE, and their homologs, which are structurally homologous to ubiquitin (Ub) and may function as the sulfide donor for the biosynthesis of thiamin, molybdopterin, cysteine, thioquinolobactin, and other sulfur-containing natural products. Ub is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Ubiquitination is comprised of a cascade of E1, E2 and E3 enzymes that results in a covalent bond between the C-terminus of Ub and the epsilon-amino group of a substrate lysine. Like Ub, small sulfide carrier proteins in this family are adenylated at a diglycyl C-terminus by specific activating proteins. The adenylated C-terminus is subsequently converted to a thiocarboxylate, serving as the sulfide source. Those activating proteins are diverse and show little sequence similarity. This family also includes the small archaeal modifier protein (SAMP), including SAMP1, SAMP2 and SAMP3, which are Ub-like proteins that function as protein modifiers and are required for the production of sulfur-containing biomolecules in the archaeon Haloferax volcanii. SAMP1 and SAMP2 are involved in sulfur transfer during molybdenum cofactor biosynthesis and tRNA thiolation much like MoaD and Urm1, respectively. They can form covalent conjugates with their protein targets through an isopeptide linkage via their C-terminal diglycine motif in a streamlined archaeal E1-dependent pathway. SAMP2 also forms homo-conjugates through the intermolecular isopeptide bond between the C-terminal Gly and the Lys58 side chain, a feature that likely resembles polyubiquitination. SAMP3 conjugates are dependent on the Ub-activating E1 enzyme homolog of archaea (UbaA) for synthesis and are cleaved by the JAMM/MPN+ domain metalloprotease HvJAMM1.	1.37951e-09
NC_008699.1\|WP_011757660.1\|4474229_4474520_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133394	cd04766, HTH_HspR, Helix-Turn-Helix DNA binding domain of the HspR transcription regulator. Helix-turn-helix (HTH) transcription regulator HspR, N-terminal domain. Heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	1.09199e-24

>NC_008699.1|WP_011757660.1|4474229_4474520_-|MerR-family-transcriptional-regulator
MTERTRGVFAISVAADMVAMQIQNLRVYERRGLVDPDRTAGGTRLYSPADIDRLHRIRDLLAAGLNLAGIAEVLRLEDRVRRLEGEVERLRGRRTP
>NC_008699.1|WP_011757659.1|4473824_4474253_+|VanZ-family-protein
MAAPFSRQTIAVALVIYAAALGFALLVPYGAVPSSGASWTAELAARLGAPAWAVEPSRWEFLANALILMPLSALGSLRWPRTTWRDWTAYAFVIAAGVELAQGLFLPERSATFTDVVANTLGGLGGAAVVLAGRRLRRTPAA
>NC_008699.1|WP_193371869.1|4473252_4473732_-|thioredoxin-family-protein
MALAVAFGSYRALTDGRFRGTHRVRQSPATPTSPAAPTSEDAAAVVEGGVSATSLGTTWTQVTKALPDATLGEQATLLQFSSAFCAPCRVTRRTLSEVADVVPGVEHLEVDAEHHLDLVRALGIMRTPTTLVLDATGQEVTRAVGAPRKEQVIAALGIT
>NC_008699.1|WP_011757657.1|4472444_4472930_-|DUF4395-domain-containing-protein
MSTTQQHHQADQAQRPAERRPAGIDPRGPQFAAALTSIALIVVLLLAPGPAAVVVLALQAAVFAVGATRGVQHTPYSWLFRTLVRPRLAVPDHLEDPAPPRFAQTVGLGFAVVALVGFLAGVDLLGLVATGFALVAALLNALFRFCLGCELYLLGRRITAH
>NC_008699.1|WP_011757656.1|4471540_4472389_-|sulfurtransferase
MSRETSLVTAQWVEEHLDDPKVVLIEVDEDTTAYDKGHIKGAVKLDWTTDLQDQVRRDFVNKQQFEALLSERGVANDHTVVLYGGNNNWFAAYAYWYFKLYGHQDLKLLDGGRKKWELDSRELTEERPTRAKTSYTAQEQDLSIRAFRDDTVAAIGVKNLVDVRSPDEYAGRLLAPAHLPQEQAQRAGHVPTSINVPWSKAANDDGTFKSDEELKALYADAGLDDAKETIALCRIGERSSHTWFVLKELLGHQSVKNYDGSWTEYGSLVGVPVAIGDEPGEA
>NC_008699.1|WP_011757655.1|4471244_4471541_-|DUF1416-domain-containing-protein
MCGATEGGLSLDGVDVKKEAIVQGQVLRDGEPVPNAYVRLLDRTGEFTAEVPTSASGHFRFFAGTGEWTLRTLAPKADPVDRRVHAEVGRVAEVVVAI
>NC_008699.1|WP_041546850.1|4469174_4471079_+|hypothetical-protein
MAVGRRALAVIVAIAVALVTGSTIALASTGQAAGEPAPARLHPVLVSGSGVGALTWHGPGAMLGEYAASITAGAIGIADQPRLATSGQADTVRIGKYATSGPAAISLALIRGNAVQLIGGVDLPAAAGVYQYGFVDGAGAPTTLPFQAGDRLGIVNESSAPLPVIAKASTAYSEEECNLDAANALTGCTIATVGWRLQVDLGVGEAAPSGPSTSASPTGPASPTGSATPTGSASPTGSASPTGSASPTGSASPTTPTGSATPSDPSDPGGVDPGTPGAPVTNCPTGIAADGWRIPKSTRAPRSLVGFDLAKDGRDKLRGTLVTSLTDNLVERLPSGRGAYYSSSTRASAYSLAGATQAVAWSEHHDVTLDSGLLLPCEAVYATLRAGGPAQPLLWAKSGGLDRLDAAVDEAGRLALVVTNAAPLDKDVRALYWPAVRKDGVYDVRAGTRLPLRGVETVRVATAGGRVVIAVAGFGRMAVYTGPITGQLREVFRARKVDPSLDVAVGRGGTPVVAYASDGRLHLLVGGRDVDTRYPAYGAAMALSKSGTVAHLAWSVKPTAEPCPTRSGLLYNCAGRNALLVADAALSNGRLRHVGIGAWLGDGVAPQVVVGPGDRAAAYYIPPTSRRLVVRPVP
>NC_008699.1|WP_041546849.1|4468514_4468940_+|D-tyrosyl-tRNA(Tyr)-deacylase
MRAVVQRADGARVVVDGAVVGGFEGEGLVVYLGITHDDGPAEITWMARKIWDVRVLRSERSASDVGAPVLVVSQFTLYGDARKGRRPTWQAAAPGPVSEPAYDAVCAELERLGARVERGVFGADMRVESVNDGPVTLILER
>NC_008699.1|WP_049774455.1|4467028_4467871_-|3-keto-5-aminohexanoate-cleavage-protein
MPTTSPEKILITVAPTGAETTKQDCPQLPTTLEELVQTAQECEAAGAAMIHVHIRDADHRPTLDQTRLRDTVQALRESTGLIVQLSTGGSVHDPLENRLKVLDAEPDSCSLTMGTTNFGDDVFSNPWPFVCELYQLSQERQVVPEFELFDLGHVHALRRLIDKFGLPYGGQVHCDFVMGVPGGMPGTAPALVAGVALLPDEVTSWSATGIGRSTLPVMLAALSMGGHLRVGMEDVLTLAKGVPVERNAQLVERAVTAARLAQRTPMQPSEARTAIGLPAR
>NC_008699.1|WP_011757651.1|4466499_4466913_-|hypothetical-protein
MKKMMVSLFSAALMGAGLVGVGAAPAQAACPYTGCVETFTHVNAPDTVVRGDRARICVKVTTGGNGRPKGRVTVLVHKSVGDYHFTDSKRYDGGRECFTTTKLNKRGKYVVKANFDRKAGSGFKDSDQRTVFRVVSG
>NC_008699.1|WP_011757661.1|4474774_4475206_+|Hsp20-family-protein
MLLRTTDPFRDFDRLTQQLFGTTNRPAVMPMDAWREGDRFVIEFDLPGVSKESIDLDVERNVLTVRAERVARNGDWEALASERPRGMFSRQLVLGDNLDLDHIEAGYTDGVLRLVVPVAEKAKPRKIQIAAGSSDTERTAIEA
>NC_008699.1|WP_011757662.1|4475261_4476080_-|hypothetical-protein
MRDRVLAAAAALTAVLVLAGSGVTSAGWTDATSIPGTSMSSGRLDLRVDGQDAVASYAPLDLPRLVPGQTAATVLTVGNQGNVALGWTATTSGTNAGNGLLAALRLLVTDATSTDGTSCGGTALPGSAATAGGTLVGTARTLAAGASEQVCVQVGLPAGAASALAGSASDLTIQVQATTGSWSDTADVGGVNLAAVPLTPPTVTCSGVLGVNLTMTWTEVPGAKEYRVFNALGTLIGTVPAGGLLQATVGALVGVTVKTVFGSEWVSAGAGC
>NC_008699.1|WP_011757663.1|4476072_4476630_-|signal-peptidase-I
MAADSRDSFLDGFRRAGEWMLLAVVLAAVLAAVVLPRLGGATPFAVLTGSMRPVMPPGTLVVVRPVDPADIDVGSVITFMPREHDPAVVTHRVVGVGFDATGQPAFRTKGDANDAPDGAMVRTYQIVGERWYFVPYLGYLTNLLTGRQREVVLGLAVAALLVYALVMFAGAARDRLRRPPGTTGA
>NC_008699.1|WP_011757664.1|4476677_4477190_-|alternate-type-signal-peptide-domain-containing-protein
MRKSTKGALAAGAAALLLFGGMGTRAGWSDDGTFTGTDIGTGHLNLINATCNGWKIGASAFDPATIKIVPGSVLTQVCTFEVDAVGTNLKATLSVTAPSFATANGLTGVLTTAATYVNNADSSPIDATTQLADGTVIKATMTVTLPASADNTIQGLTATLDNVTVTATQA
>NC_008699.1|WP_011757665.1|4477394_4477667_-|MoaD/ThiS-family-protein
MSLAPIEVHYWASARSAAGVASDALAVQGPITLAEVLERAVALHPGTRLPDVLKICSTLVGDRPVNSEDPEGVLVPPGSSVEFLPPFAGG
>NC_008699.1|WP_140404068.1|4478507_4478894_-|hypothetical-protein
MTCVPDDDHEVLRLQLMTAGRGLLAAFEAGDDVTMARGRVARVCETALVPRLEEDERCLLQAAQRADTRLLAEAMRAQIRAITAITRELAGPVQPWEAVAATRALYTMLAAYTHHHALLSSALGAPAA
>NC_008699.1|WP_011757668.1|4478908_4481437_-|MMPL-family-transporter
MLRTLATFSVRHRFLVVIAWLILVAGVLFAGQSYGGSFSNDLSLKDTDSQQAYDELRAKFPEMSGDGMQVVIHDDKGVDQGQVRAAVEAAVADVAGRPGVASAASPYGPGPQMVSADGTTAVATVRFDERATDIAEADLTAAQEAFAPVADLGVQVEYGGAALDAENHPSGSEAIGLAAAVLVLLLAFGSVFAMLVPLLTAVLALGLGMGIIFLLSDQVTIGTAGPVVAAMIGLGVGIDYALLVVTRHREGLATGHSARESIPIALSTAGRSVLVAGTTVIIAILSLYAIGIPFVATLGLASAITVATTMLAAVTLLPALLAVFGDQLDRLRVRRPRLDHGGGRVSGWHRWTRHVQRRPWPYLLAAVAVLATLAIPLLDLRLGTADDGSAPVGSTERAAYDLIATDFGPGWTGPLVVTASYPDGTAAETQRSAKALAGEIAGVEGVEQVSPPAVNEAGDTAVLTVVPSTSPDDQATEDLVHRLRDQVGRDGAADDTRAQPQARPEPEVHVGGATATNIDLADKLTDRMPWFMAFVVGLSFLLLLVEFRSIFVPVKAALMNLLSVGAAYGAVVAIFQWGWLSDVFGAQPGPIESFAPMMLFAVLFGLSMDYEVFLLSRVREEYLRTGQAGAAVADGIAATARVITAAASVMVVVFASFLLNDDRVVNLFGFGLAVAIAIDATLVRLVLVPALMAVAGRLAWYLPPWLDRVLPRIELEPHPVDPYEEELDRLDPDVRDVVLAEEPPVPAGPGAHLERGAEDPRAALETLRDVVAERDAYLQDYLETRAELERVRAQHEAVVEALRTIQEAGAGNGVALNGSRAARRSRRAQAAPRARDGDGDGG
>NC_008699.1|WP_011757669.1|4481436_4482297_-|inositol-phosphorylceramide-synthase
MLDRPARHLRLRAALVELVLVAALFNLYRFGRAAIDGQQATARHNAELVTDAQRALGLPSEASLQRLLDVELLLRLANTYYTFVHFPLMVAFLAWGFVRRPRHEYVWARNLIAVQTGAALVIHMAFPLAPPRMFPEWGFVDTMAVYGPSAYDGVSGDVANQFAAMPSLHVGWAVAIAYIVFRTGPRPLAVLAALHASVTYLVVILTANHWWLDGVVAIALLALAAALTRLRAARAAARAAARAAARARMRGSLPGPATVPASETTVSQLVREGPVGPGRPPHRREP
>NC_008699.1|WP_011757670.1|4482474_4483113_+|TetR/AcrR-family-transcriptional-regulator
MTVRPAGLAGARGQAREKTRDAVLQAALRLFSEHGYLAVRVEDIAREAGVSRATFYKHFAEREEILAMLLTRLLGADEGAGTEVEQPAGDLAARVQALGRAIVDRMLEQEQLARFVYSLPVRHEALLGAQQLPRPSAFGRVDRLLDAADAAGELRDGVPLAVVRTQVHAAIETALREWATGQATDPHERLAQHLDVVLHGAAAPTRKAIRRR
>NC_008699.1|WP_140404069.1|4483137_4483830_-|TetR/AcrR-family-transcriptional-regulator
MCTRVYAGRVTHPSPLPDRSPVARGRARARHTRDAVVETALRLFSEHGYLAVRVEDIAREAGISRATFYKYFSEREEILAALLTRLLDDQAAAQVDRVHADGAAGPDGTTPDVSTRVRALAREVAERTLEREELARFVYALPVRHEALLNVEPLRRPRACRQLDGLLAEAGATGELRADVPLGAARAHVHAAIETALRAWATGQAPDALAEVDRQLDLALYGVLGLPHAG

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Crispr_ID: NC_008699_31

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_31

4745716-4745800

Orphan

Consensus_repeat	Method
CGGTTTCCCCGGTTCACCGGGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_31

>merge|NC_008699|31|4745716-4745800|CRISPRCasFinder
CGGTTTCCCCGGTTCACCGGGGATGTTGGAACTTCTGGCCCGAAGTTTCGGCCCAACAGTTCCGGTTTCCCCGGTTCACCGGGGA

>NC_008699|31|31|4745716-4745800|CRISPRCasFinder
CGGTTTCCCCGGTTCACCGGGGA	TGTTGGAACTTCTGGCCCGAAGTTTCGGCCCAACAGTTC
CGGTTTCCCCGGTTCACCGGGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011757917.1\|4747690_4749217_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238625
NC_008699.1\|WP_011757920.1\|4752681_4753326_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_140404141.1\|4741801_4742689_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NC_008699.1\|WP_041546918.1\|4754065_4755538_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_008699.1\|WP_011757908.1\|4738824_4739994_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NC_008699.1\|WP_011757918.1\|4749316_4750780_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NC_008699.1\|WP_041546914.1\|4745815_4746772_-\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131
NC_008699.1\|WP_011757914.1\|4744507_4745632_-\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NC_008699.1\|WP_011757912.1\|4742715_4744122_-\|glycoside-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|366376
NC_008699.1\|WP_011757921.1\|4753368_4753941_+\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NC_008699.1\|WP_011757924.1\|4756560_4757379_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|372253
NC_008699.1\|WP_041546912.1\|4744118_4744313_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223472
NC_008699.1\|WP_011757916.1\|4746808_4747708_+\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238861
NC_008699.1\|WP_011757909.1\|4740063_4740849_-\|glucosamine-6-phosphate-deaminase	unknown	unknown	gnl\|CDD\|238693
NC_008699.1\|WP_041546910.1\|4737600_4738719_-\|ferredoxin-reductase	unknown	unknown	gnl\|CDD\|99812
NC_008699.1\|WP_041546920.1\|4755655_4756564_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NC_008699.1\|WP_011757906.1\|4736349_4737579_-\|acyl-CoA-desaturase	unknown	unknown	gnl\|CDD\|239583
NC_008699.1\|WP_011757905.1\|4735199_4736228_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_008699.1\|WP_140404134.1\|4740848_4741802_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238434
NC_008699.1\|WP_011757919.1\|4750870_4752544_-\|phenylacetic-acid-degradation-protein-PaaN	unknown	unknown	gnl\|CDD\|143445

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011757917.1\|4747690_4749217_-\|amidohydrolase-family-protein	gnl\|CDD\|238625	cd01300, YtcJ_like, YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.	6.01646e-88
NC_008699.1\|WP_140404141.1\|4741801_4742689_-\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	3.71672e-50
NC_008699.1\|WP_041546918.1\|4754065_4755538_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.29908e-84
NC_008699.1\|WP_011757908.1\|4738824_4739994_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	8.76816e-14
NC_008699.1\|WP_011757918.1\|4749316_4750780_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.96815e-72
NC_008699.1\|WP_041546914.1\|4745815_4746772_-\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	4.16468e-29
NC_008699.1\|WP_011757914.1\|4744507_4745632_-\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	5.49797e-49
NC_008699.1\|WP_011757912.1\|4742715_4744122_-\|glycoside-hydrolase-family-protein	gnl\|CDD\|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	3.52572e-68
NC_008699.1\|WP_011757921.1\|4753368_4753941_+\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	3.46273e-44
NC_008699.1\|WP_011757924.1\|4756560_4757379_+\|ABC-transporter-permease-subunit	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	1.25302e-06
NC_008699.1\|WP_041546912.1\|4744118_4744313_-\|hypothetical-protein	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	6.11813e-14
NC_008699.1\|WP_011757916.1\|4746808_4747708_+\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238861	cd01823, SEST_like, SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxylic acid.	1.0804e-53
NC_008699.1\|WP_011757909.1\|4740063_4740849_-\|glucosamine-6-phosphate-deaminase	gnl\|CDD\|238693	cd01399, GlcN6P_deaminase, GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.	2.77819e-116
NC_008699.1\|WP_041546910.1\|4737600_4738719_-\|ferredoxin-reductase	gnl\|CDD\|99812	cd06216, FNR_iron_sulfur_binding_2, Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.	1.72364e-103
NC_008699.1\|WP_041546920.1\|4755655_4756564_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	2.76478e-90
NC_008699.1\|WP_011757906.1\|4736349_4737579_-\|acyl-CoA-desaturase	gnl\|CDD\|239583	cd03506, Delta6-FADS-like, The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases are required for the synthesis of highly unsaturated fatty acids (HUFAs), which are mainly esterified into phospholipids and contribute to maintaining membrane fluidity. While HUFAs may be required for cold tolerance in bacteria, plants and fish, the primary role of HUFAs in mammals is cell signaling. These enzymes are described as front-end desaturases because they introduce a double bond between the pre-exiting double bond and the carboxyl (front) end of the fatty acid. Various substrates are involved, with both acyl-coenzyme A (CoA) and acyl-lipid desaturases present in this CD. Acyl-lipid desaturases are localized in the membranes of cyanobacterial thylakoid, plant endoplasmic reticulum (ER), and plastid; and acyl-CoA desaturases are present in ER membrane. ER-bound plant acyl-lipid desaturases and acyl-CoA desaturases require cytochrome b5 as an electron donor. Most of the eukaryotic desaturase domains have an adjacent N-terminal cytochrome b5-like domain. This domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain the residues: HXXXH, HXX(X)HH, and Q/HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homolog, stearoyl CoA desaturase.	2.64944e-44
NC_008699.1\|WP_011757905.1\|4735199_4736228_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.90634e-116
NC_008699.1\|WP_140404134.1\|4740848_4741802_-\|amidohydrolase-family-protein	gnl\|CDD\|238434	cd00854, NagA, N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to amino-sugar-nucleotides, which is needed for cell wall peptidoglycan and teichoic acid biosynthesis. Deacetylation of N-acetylglucosamine is also important in lipopolysaccharide synthesis and cell wall recycling.	2.28955e-106
NC_008699.1\|WP_011757919.1\|4750870_4752544_-\|phenylacetic-acid-degradation-protein-PaaN	gnl\|CDD\|143445	cd07127, ALDH_PAD-PaaZ, Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like. Phenylacetic acid degradation (PAD) proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida) are putative aromatic ring cleavage enzymes of the aerobic PA catabolic pathway. PaaZ mutants were defective for growth with PA as a sole carbon source due to interruption of the putative ring opening system. This CD is limited to bacterial monofunctional enzymes.	0

>NC_008699.1|WP_011757914.1|4744507_4745632_-|ROK-family-transcriptional-regulator
MSPVGRPLRPRGKLLQEDARRHHRSLLLQQLFREGPASRADLARTTRLTRVTVSDLVGELVGEGLVEELGAPAEARVGKPPTLVGLAPDASHIIGLDLSADDRMTGAVVNLLGQVQARHEIEIGDAQGEAAVRLVHRLAAELIAMTDRPVLGVGVGSPGVVDAAGTVIDAPNFAWTDTPLSTTLAAALGVPVFVANDANTAVLGEHTFGQTGDGGLMVLRVGIGVGAGLVLGGSLLHGHLGAAGEIGHVTVDPDGDVCACGRRGCLETILAAPRLRRRLAEPGADRDAVLTEVGERLGVTLAPVVGTLNIHELVLSGPTELLDGPLRAAADRVVRERTMPVSSAGLTVRTSTLGADVVLIGAAVLVLSGQLGVS
>NC_008699.1|WP_041546912.1|4744118_4744313_-|hypothetical-protein
MVVMSQGDKKTLPLWLSIFTDLNRGTDWGGIMAGSTLIAIPVVIFFLVVQGRMVAGLTSGAVKG
>NC_008699.1|WP_011757912.1|4742715_4744122_-|glycoside-hydrolase-family-protein
MSDLTRSRPENGQSLEQLALRVLLPAFPGTTLARDVAGLFAEGLGGVCLFGSNTADGPAAVAELTSAIHAAAPYAVVAVDEEGGDVTRLHALDRSPVLGPAALGAAGDLALTRETGAAIGTELAAAGIDLDLGPVADVNSDPDNPVIGTRSFGTDAAAAAAHTAAWVAGLQGAGVAACAKHFPGHGDTAQDSHLALPMVDVDLPTLLGRELAPFAAAVEAGVASVMTSHILVPAVDPALPATLSRPVLGLLRDHLGYGGVLVTDALDMAGASAGRGIPEAAVLSLAAGADLLCLGADKDIALVRQVQAAIVAAVRSGRLAEERLVEAVDRIARLPRGAGSAAPVDAARQLAGARRAVTVEGELPDLRGAEVVSVATPANIAIGEVPWGLPPDRFLQPGEPVTGDRPVVLQVRDAHRRPEVLVEGAAVVVEWGWPGPYAGGTPRICTRGYSRPGAVAVTELLRKAGWDR
>NC_008699.1|WP_140404141.1|4741801_4742689_-|ROK-family-protein
MGLDIGATKTLGLVVDEDGGIRATVREATEPGAEGVVRTAARVVEALRAATGERLAGTVGVGMPGLVDVERGAVKHAVNLGVNGDWLPLGDLLGDRLGTPVVVENDVNVASLGAVAMSGEDDLVYLSIGTGLAAGLVLAGRLRRGDHGAAGEIGHVPVDPAGALCQCGQRGCLETIASGSALAAAWPSEDVPPAQALFAAAHASDPDAIAARDRFAAGVASAVRVLGLAVDPRTVVLGGGVAQLGEPLRAAVADALREQARTSPFLASLDLAGRLRVVPAHYPVAAVGAALLGRS
>NC_008699.1|WP_140404134.1|4740848_4741802_-|amidohydrolase-family-protein
MSIVVPGLVDAQVNGAAGIDLTTEPHRLWEVAAALPAYGVVAFVPTVITSDPAARGQALATLAAGPPPGWSGAEPLGLHFEGPMIAPTRKGAHPERWLRPPSLDLVDGWSRESGVVIATIAPELPGALEVIERLAARGVVVSVGHTAASAAEVAAALEAGARCLTHLGNAMPPLQAREPGPVGAAFGSDPGTGPVAGLIVDGHHLDPLFVRAAWRALGPDRFLSVSDTTAGLGLPDGPARLGDQDVVVADGTVRLADGTLAGSAASLLDCLRILLAQTGCTLEEAVATATSTPLRLLGLPPREERIRLTDDLRLEVH
>NC_008699.1|WP_011757909.1|4740063_4740849_-|glucosamine-6-phosphate-deaminase
MEIVPLATEPEVAGLAADAIEALVRAHPESVLGLATGSSPLPAYQELIRRRRAGSGPSYAGVRAFLLDEYVGLPPGHPQSYRETIFRELTDALDIDRDRVASPDPTPDLLSTAGERYEDAIRAAGGVDLQVLGIGADGHLAFNEPGSSLGSLTRLKTLTGETRADNARFFDSVDQVPRHVLTQGLGTILRAGRLLLVATGAGKAAAIAAAVEGPVSASCPASVLQLHPHVTVLLDEAAAAQLTRTAYYREVFDDKPDWQRP
>NC_008699.1|WP_011757908.1|4738824_4739994_+|helix-turn-helix-domain-containing-protein
MVRRPVRHTADHGLRLDSGAVTEMRTELPRVAEHVVAAIIDEVPSYTDAFSGPMGETIRNAVQLALGGFLSLASGSRGADRSTPAAPAVEGAYQLGRGEARSGRTTDALLAAYRIGARVSWREMSTVAVRNGVAGETLVAFAELVFAYIDELSAASVAGHTDELDTSGRVRQRLLERVAHHLLTGSPVDQVAAAAERAGWDPPRTLTAVIVPEAQVRPVLAALSPATLQVTDPPGLDDGALLLVPDAHEHRRRALLRVLADRGALAGPARPWLEARASYDRALRARAAGVELDTEAHLVGLVLEADATARADLRAQALAPLAGLRPATAEKLTDTLRSWLLHQGRREQVAAELFVHPQTVRYRMGQLRELYGERLDDPDTVLALVVALG
>NC_008699.1|WP_041546910.1|4737600_4738719_-|ferredoxin-reductase
MSVAIPSAASRSGSGWSLRSTLRQVAQAAVTPRDLDDVLDHFHPLRRGTDLRGRIVEVRPETAASATVVIKPGRDWTGHVPGQYLRVGVDVDGVRLWRTYSLTHGPRADRCISITVKAIPGGVVSNHLVHRIRPGQMIQIGQAEGEFVLTQPIPDKLLLVTAGSGITPVIGMLRNLFSRAVRPTTDIVLLHSALSRSEVIFGEELRRYGAAGWLRLVELHTDTHGLLQVGDPEAGLDRIVPDLAERTAYACGPAGLLDALQEHYDARGLELNVERFRAPMVATGEGGTLTFTSGVAVAADGATPILDAAESAGVLMPSGCRMGVCFGCVLPLREGAVRDLRNGQLTTAAPGDGVIIQTCINAVAGECHLDHA
>NC_008699.1|WP_011757906.1|4736349_4737579_-|acyl-CoA-desaturase
MTAIQKKPVSPVAHLTPEDVEQIGIELDAIRQDVLDSRGERDARYIHRVIDVQRRLELGSRAVLLFSSFPPAWIVGTAGLSVAKILENMEIGHNILHGQWDWMRDPKIHSTTWEWDMATPAAQWQHSHNELHHTYTNVIGKDNDLGYGIMRVDEDQPWHPFFLVQPLWNFINACFFEYGIAAYDLELGATVKRKQTKDPGFQRRLKAVLTKVRRQATKDYLVHPALSIPTGSFLATLAANFTANVVRNLWSHSVIMCGHFPEGVETFEKRSIDGETRGEWYLRQMLGSANISGSKAVHIMSGNLSHQIEHHLFPDLPSNRYAEIAPRVQALFEKYDLNYHAAPLPKQVYSAWHKVVRLSLPNGWLATTNVKNAPQQLALLYKMATGGPKVRRAAQARLTQQARKAGAAG
>NC_008699.1|WP_011757905.1|4735199_4736228_+|LacI-family-DNA-binding-transcriptional-regulator
MRGVTPTLRDVADAAGVHPATASRALNPATRGLVNADTARRVIKVAESLGYRPNPIARGLKTAKSGTVGLVIPDLTNPLFPPIVRGIEDVLEPAGYSGLIVNTDNDPSRERAQFESLRSRQVEGFIVATALLDHPLLDQLRREGVLMVMVNRRPDGLDVPSITPDDAAGVELAVRHLAELGHRRVAHLAGPSNTSTGVVRARSFRNTVRDLGLDEDPALTVTCPYWSETAGAEALRSLLDSGAEFTAVVAGNDLIALGCYDVFAERSIECPRDVSVVGFNDMPFLDKLRPPLTTVAVPHQQIGAEAARMLLDAIRDPSRPARSVLLPLSLVVRGSTAPPYSG
>NC_008699.1|WP_041546914.1|4745815_4746772_-|cation-diffusion-facilitator-family-transporter
MATPTLPSESSGGESLLTVLVALVANGLLAIAKSVAAAVTGSASMVAEAAHSWADTGNEVFLLVAERKGSRPRDEEHPRGYGRSTYIWSLVAAFGLFSAGAVVSLWHGITELTGEEAAPSYAVNYIVLGVAFVLEGVSFAQATRQVHGAARRFGLHPLRFVSRTSNPTLRAVFFEDSAALAGILLAGAGIALHQVTGEAVFDALGSIAVGILLGFVAVFLMRRNMDYLLGEGLTPELRSRVIAQLLEHPQIDRITYLHVEYVGPQRLFVVAAVDLTGDDREGHLAVRLRDVEAEIERNPLIEDAVLTLAPPDEPALMP
>NC_008699.1|WP_011757916.1|4746808_4747708_+|SGNH/GDSL-hydrolase-family-protein
MLRPIVPALAVALAAALGLSGCAGSDEPVAAPARSTGSPTAAPTAYDQYVALGDSYTAAPLVPPTDGSSICLRSGVNYPALVAQAMPGTELTDVSCSGARTANVTSPQTGQRGGRVPPQLTAVRPGTDLVTISLGGNDDHLFGGTLGQCVQLAPTDPAGAPCRAAVDASSLTRTFEHIRANLSGVVDAVRGRSPHARILLVGYPQIVPASGTCDLLPLADGDYAFARSVTEDLNRTVQAAADDTGVEYVDLWGPSAGHDICADDPWVNGRVTSAETALAYHPLAAGQRAAAEAVLAELR
>NC_008699.1|WP_011757917.1|4747690_4749217_-|amidohydrolase-family-protein
MSSILIRNARLVPIGPGAEVPDQPVDVAVVDGVVTAVGPGAERPAGAEDVDAAGRWLIPGLWDQHVHLGQWTLTSQRLDLARARSPEDATRAVAEWIAAYPGLPVIGWGHRSAGWHREVTVSELDAVSGDTPVVLISGDAHHAWLNTTALMHLAIPVRDSVVRETEWFAAYPRLVTLVGSDGTSPEAYRRTLDAAAAQGVVGVVDFEFGASREEWAERWALGCDRLRIRWATYADTLDEVIAAGLRTGDPLPGCDDRATMGPLKIISDGSLNTRTAWCCEPYGDAHRLEYPAGQPNLDGAELRGLLARAHAGGLEVATHAIGDAAVAEALASYAETGARGSIEHVQMARREDLRTLARLGLRASVQPAHLLDDRDLTERIWGERAERCFAFRWMLEDGVRLAFGSDAPVSPLDPWLAMAAAVHRSADDRDPWRAEQALTVREALAASVDGQPTVGVGSPGDLVLLDRDPLLPDLDAGDTAGLGTALRSLGSALTVVAGVPVHRSAELG
>NC_008699.1|WP_011757918.1|4749316_4750780_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MTDLKSRWLALYVLCLGDLMIVLDSSIVNVALPSIQADLGFTRSALAWVVNAYLLTFGGFLLLSGRLGDLLGNKRVFLGGVVSFTVASVACGLAPSSGLLVVGRAVQGLGGAAVSAVALSLIMGLFSDPAERARAMGFFGFVMSGGGAVGVLLGGVLTGLFSWHWIFLVNVPIGVGVWLAARRVLPADEVVPGAGRLDVPGAVLVTAALMLSVYGIVGGNEAGWTSGRTLGLLGASAVLLAAFVLREARAASPLVPLRLFALRNVSVSQVVGMLWAAAMFAWFFLAALYLQQVLGYDALEVGLAFVPTSVVMAFCSLRVSDRLVMRFGIRRPLMAGLALAAASLALFSRAPVDGSFGTDVLPSMLLLGAGAGIAFNPVLLAAMGDVEPHESGLASGVVNTSFMMGGALGLAVLVSLSTWRTESLAADGADRLEALNGGFQFAFATGALAALAAAVIGGLLLRPKPMGGAELDAVAIADEPTLDASLG
>NC_008699.1|WP_011757919.1|4750870_4752544_-|phenylacetic-acid-degradation-protein-PaaN
MTETTAGALFDRHRARLDAAVAACASREYYSAFDESPSPRVYGETAAAEGKAAFEAWLGSPFPLPTPGAQGSVATERSPYGVDLGVSYPRAVDVDALLSAARAGMKGWRDAGPDGRTGVCLEILARLHARIFELANAVQHTSGQAFVMAFQAGGAHALDRALEAIAYAWTEMTRTPATAIWEKPGRGGPLRMEKTFTVVPRGVALVIGCNTFPTWNSWPGLFASLVTGNPVVVKPHPAAVLPLAISVQVCREVLAEAGFDPDLVLLAAEEPEDRLAATLAVRPEVRLIDFTGGNAFGDWLEANAGQAVVFTEKAGVNTVVVDSTSDFAAMCQNLAFSFALYSGQMCTAPQNVYVPAAGIATEDGVRSPAEVGAGIGAALQGLLGDDARAVELLGGIVNDGVLARLEKAGRGHVLVPSREVAHPAYADATVRTPMLVGLTAEDSDVYESECFGPVAYLIETEGTDQSIDLFRHTVLAHGAMTAAVYSTSPEVVEQVREAALEAGVALSENLLGGVFVNQSAAYSDFHGTGANPAANAAYTDGAYVASRFRVVQSRRHV
>NC_008699.1|WP_011757920.1|4752681_4753326_+|hypothetical-protein
MRVRWAGLVLALILAGAAAGYGLGSLDHHEPAAIDHPEPVPARSPSIPVDPTPTFAPDVDYPALATDLRYRTRRIGDPPFFQWEYDAPRGWVRTTTDQPDEFRWRPADEPPVGGYSLRVKIVTQRLTPEQMVEQKIAAVESIYDDVEIVDQDEDEVYFTYRDGLDHQRHNLFWWFPAPGQTAASFEMSVAGRGVDLPGLEALETRVAASVRKVP
>NC_008699.1|WP_011757921.1|4753368_4753941_+|TerD-family-protein
MIELHPGDELDLAAADGTPLTELRMGVGWDKERTAGFIGTGAPDIDLDASAVQFAGGQLFDLAFYNNLATRDGSVVHLGDNKTGSGAGDDETIAVDLAKVYGAVDTVVFLVSSYQGHTLEWINNAYCRLVAGDPDGTELARLTLTAGVPETGVALAKLYRSGDGWRLRAIGQGIRLTVPTQGLDVLRPFL
>NC_008699.1|WP_041546918.1|4754065_4755538_-|serine/threonine-protein-kinase
MPMPSRLGRYAVRRRIGSGGFATVWLAYDEQLDSPVAIKVLADNWTEDQAVRQRFLEEGRFLRKVESPYVVSVYDAGELEDGRPYLVMSYADQGTLADRLEVLGLTPGQALEVVRQVGAGLQALHVRGVLHRDVKPANVLFRTVEEGGRSEVRAMVADLGLGKALDMSSRLTMIAGTPSFVAPEQAQGEPLDARADQYSLAALTYLMLCGRAPYSHASLAAAAAPCAPPALSTPERPFPDAVEAVVRRGLAADREDRWPDVAAYVEALAAALGADADADPSGPWLPLDPDLTRPGARPSPLPPSRPLADPVPPRRTGRRVLAAIVGLVALAAGAGVGYAVEQHGDAEVSLTDRTGTLSVIVPSDWDRARSTRMWQAPGGGGEFPALSVGSSADWTDAGSTAQGVFLGILPGDELPEQVPQHPECGTADDPVDDTIDDNPTRTVVYTRCPGGVTVERVVQLASNRLLWVQVRSADRATATAVLDDVEAHGY
>NC_008699.1|WP_041546920.1|4755655_4756564_+|ATP-binding-cassette-domain-containing-protein
MITVESLTKTYGGFTAVDDVTFTARSGRVTGFLGPNGAGKSTTMRIMVGLTPATSGTAQVSGRRFADLPNPGLEVGVLLDASAQHAGRTGREILTIAQRTMGLPARRVDELLDLVSLTPDEAGRRVRNYSLGMRQRLGIATALLGDPEVLILDEPANGLDPAGIRWMRDLLRGYADQGGTVLLSSHLLHEIEVIADDLVVIGQGRIVAQGTKAELLAAAGTLVRTPDLPTLARALVSADVEFTRTADALRVEADPDLVGRLALAAGVPLTELRAGDGAGLEEMFLELTADTQRDEISEGAAA
>NC_008699.1|WP_011757924.1|4756560_4757379_+|ABC-transporter-permease-subunit
MTTLTLEHEHEHAPVRVERAVPAPIPMSRLIAVEARKSFDTRSGFWMLASVGILATLATAATILFAPDSEITYMTFGTAIGVPMAIILPMIAVLSVTSEWSQRTGLTSFTLVPHRGRVVNAKLTVAVTVGVVSMLLALGIGALGNLLGAAVVGIDPVWDVPAADLVGLLLFQIVNMLIGFMLGVLFRNSAGAIVGYFVYSFVLGTITQVLSASQDWFERIQPWIDFNYTQGSLTEMSGMTAENWAQFGVTGLVWLVLPLAIGLRAVLRSEVK

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Crispr_ID: NC_008699_32

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_32

4772284-4772369

Orphan

Consensus_repeat	Method
TTCCCCGGTGAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_32

>merge|NC_008699|32|4772284-4772369|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCGGAACTTCCCGGCCGAAACTTCGGTCCAACAGTTCCAACTTCCCCGGTGAACCGGGGAAACCG

>NC_008699|32|32|4772284-4772369|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCG	GAACTTCCCGGCCGAAACTTCGGTCCAACAGTTCCAAC
TTCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011757938.1\|4772383_4773358_-\|glutathione-S-transferase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|223512
NC_008699.1\|WP_041546927.1\|4765113_4766382_+\|ArgE/DapE-family-deacylase	unknown	unknown	gnl\|CDD\|349890
NC_008699.1\|WP_041546922.1\|4762359_4763178_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187589
NC_008699.1\|WP_140404132.1\|4780485_4781049_+\|DUF3558-domain-containing-protein	unknown	unknown	unknown
NC_008699.1\|WP_011757933.1\|4766437_4767862_-\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NC_008699.1\|WP_011757945.1\|4778372_4779077_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_008699.1\|WP_011757937.1\|4771245_4772271_+\|family-43-glycosylhydrolase	unknown	unknown	gnl\|CDD\|350113
NC_008699.1\|WP_162094031.1\|4779070_4780489_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NC_008699.1\|WP_041546925.1\|4763199_4764087_+\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132866
NC_008699.1\|WP_011757935.1\|4768855_4770052_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NC_008699.1\|WP_140404138.1\|4776917_4777421_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|319971
NC_008699.1\|WP_011757928.1\|4760738_4762232_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha/beta	unknown	unknown	gnl\|CDD\|223848
NC_008699.1\|WP_011757944.1\|4777417_4778296_+\|fructosamine-kinase-family-protein	unknown	unknown	gnl\|CDD\|367711
NC_008699.1\|WP_049774480.1\|4770233_4771148_-\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
NC_008699.1\|WP_011757934.1\|4767873_4768854_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NC_008699.1\|WP_011757940.1\|4774594_4775665_-\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|179559
NC_008699.1\|WP_140404139.1\|4776446_4776827_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377198
NC_008699.1\|WP_011757931.1\|4764108_4765080_-\|DUF2804-domain-containing-protein	unknown	unknown	gnl\|CDD\|378522
NC_008699.1\|WP_041548293.1\|4773408_4774425_-\|glycoside-hydrolase-family-3-protein	unknown	unknown	gnl\|CDD\|224389
NC_008699.1\|WP_041546931.1\|4775674_4776256_-\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011757938.1\|4772383_4773358_-\|glutathione-S-transferase-C-terminal-domain-containing-protein	gnl\|CDD\|223512	COG0435, ECM4, Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	9.25267e-139
NC_008699.1\|WP_041546927.1\|4765113_4766382_+\|ArgE/DapE-family-deacylase	gnl\|CDD\|349890	cd03895, M20_ArgE_DapE-like, M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases. Peptidase M20 family, uncharacterized protein subfamily with similarity to acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE) subfamily. ArgE/DapE enzymes catalyze analogous reactions and share a common activator, the metal ion (usually Co2+ or Zn2+). ArgE catalyzes a broad range of substrates, including N-acetylornithine, alpha-N-acetylmethionine and alpha-N-formylmethionine, while DapE catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelate (L,L-SDAP) to L,L-diaminopimelate and succinate. Proteins in this subfamily are mostly bacterial, and have been inferred by homology as being related to both ArgE and DapE.	3.26367e-110
NC_008699.1\|WP_041546922.1\|4762359_4763178_+\|SDR-family-oxidoreductase	gnl\|CDD\|187589	cd05328, 3alpha_HSD_SDR_c, alpha hydroxysteroid dehydrogenase (3alpha_HSD), classical (c) SDRs. Bacterial 3-alpha_HSD, which catalyzes the NAD-dependent oxidoreduction of hydroxysteroids, is a dimeric member of the classical SDR family. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	4.13687e-50
NC_008699.1\|WP_011757933.1\|4766437_4767862_-\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	3.85615e-155
NC_008699.1\|WP_011757945.1\|4778372_4779077_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.77014e-84
NC_008699.1\|WP_011757937.1\|4771245_4772271_+\|family-43-glycosylhydrolase	gnl\|CDD\|350113	cd08999, GH43_ABN-like, Glycosyl hydrolase family 43 protein such as endo-alpha-L-arabinanase. This glycosyl hydrolase family 43 (GH43) subgroup includes mostly enzymes with alpha-L-arabinofuranosidase (ABF; EC 3.2.1.55) and endo-alpha-L-arabinanase (ABN; EC 3.2.1.99) activities. These are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. The GH43 ABN enzymes hydrolyze alpha-1,5-L-arabinofuranoside linkages while the ABF enzymes cleave arabinose side chains so that the combined actions of these two enzymes reduce arabinan to L-arabinose and/or arabinooligosaccharides. These arabinan-degrading enzymes are important in the food industry for efficient production of L-arabinose from agricultural waste; L-arabinose is often used as a bioactive sweetener. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	3.03237e-74
NC_008699.1\|WP_162094031.1\|4779070_4780489_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.17673e-58
NC_008699.1\|WP_041546925.1\|4763199_4764087_+\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132866	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6. Bacterial patatin-like phospholipase domain containing protein 6. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This group includes YCHK and rssA from Escherichia coli as well as Ylbk from Bacillus amyloliquefaciens.	2.9551e-66
NC_008699.1\|WP_011757935.1\|4768855_4770052_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	1.6118e-174
NC_008699.1\|WP_140404138.1\|4776917_4777421_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	1.14263e-47
NC_008699.1\|WP_011757928.1\|4760738_4762232_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha/beta	gnl\|CDD\|223848	COG0777, AccD, Acetyl-CoA carboxylase beta subunit [Lipid metabolism].	2.48808e-83
NC_008699.1\|WP_011757944.1\|4777417_4778296_+\|fructosamine-kinase-family-protein	gnl\|CDD\|367711	pfam03881, Fructosamin_kin, Fructosamine kinase. This family includes eukaryotic fructosamine-3-kinase enzymes. The family also includes bacterial members that have not been characterized but probably have a similar or identical function.	1.13004e-59
NC_008699.1\|WP_049774480.1\|4770233_4771148_-\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	2.9252e-82
NC_008699.1\|WP_011757934.1\|4767873_4768854_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	5.16401e-151
NC_008699.1\|WP_011757940.1\|4774594_4775665_-\|histidinol-phosphate-transaminase	gnl\|CDD\|179559	PRK03321, PRK03321, putative aminotransferase; Provisional.	7.97122e-170
NC_008699.1\|WP_140404139.1\|4776446_4776827_+\|phage-holin-family-protein	gnl\|CDD\|377198	pfam04020, Phage_holin_4_2, Mycobacterial 4 TMS phage holin, superfamily IV. These proteins are predicted transmembrane proteins with probably four transmembrane spans. The 1.E.40 is represented by the mycobacterial 4 phage holin, but it also contains many cyanobacterial. proteobacterial and firmicute proteins. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as in those of the bacteriophage of these organisms. The primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded the enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases.	4.90551e-17
NC_008699.1\|WP_011757931.1\|4764108_4765080_-\|DUF2804-domain-containing-protein	gnl\|CDD\|378522	pfam10974, DUF2804, Protein of unknown function (DUF2804). This is a family of proteins with unknown function.	3.71403e-107
NC_008699.1\|WP_041548293.1\|4773408_4774425_-\|glycoside-hydrolase-family-3-protein	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	3.86784e-59
NC_008699.1\|WP_041546931.1\|4775674_4776256_-\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	1.11003e-06

>NC_008699.1|WP_011757937.1|4771245_4772271_+|family-43-glycosylhydrolase
MGWGRRAAAAALTMVLAALLTTALTVELMPDASAVRLRPPAQRVTPVLHREGFADPSVVSIAGGYLAISTGFRAPRAVSSSPRGPWHPVSRALPKKLPHWVRSPQIWASELVRSRTGWLLYYSAVAHGKTRRCIGVATARHPLDAFRPVGRRPLVCPQRGAIDPSGFVRSNGGRYLLFKTQGNPTSIRLLRLTRDGRHRGHRAHSRVLLRSQHTIENPVLVRRKRHLVLFTSEGYFGSCGYETTWRRSKNLFRWGRSEPHPLLRRTNTRICGPGGADVLTAGRKNPVLYFHGWTCGKGRRPCPPRFVLGRAERPYARRVMYAAHLRWKHGTPRVHGFIRRH
>NC_008699.1|WP_049774480.1|4770233_4771148_-|cation-transporter
MGHDDDHAAGRAEDRGRLRVVLAVTVVVMAVEVVGALLTGSLALLADAGHMATDAAAVVLALGASYVASRGGGPRSTFGLHRAEILAALVNALALLVVCGYLAWAGISRLADPVSVDAGPMVAFAAVGLVANAVSLVILNRSETGSLNLRGAANEVFADLVGSVLAVLAGAVIWVWGLDRADPIASLVIAALILPRSLVLLRESAAILLEVAPRGLDLDDVRRHLLAMPGVLDVHDLHAWTITSGMPSLSAHVTVTEEALAELGVGGVLDRLSECTAEHFDVRHSTFQVEPVTHREHEDLGEVH
>NC_008699.1|WP_011757935.1|4768855_4770052_-|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MTQQAAGGNPAHTAGFGPDLAEVFGPAQQDGGPELVQLLTPEGERVEHPDFSFDLGDDTILGFYRDMVLTRRIDTEATALQRHGELGIWAQLLGQEAAQIGAGRALRPQDFVFPTYREHGVAWCRGIDPLDLLGLFRGVDQGSWDPKDKNFGLYTIVIGAQTLHATGYAMGMQRDGVVGTGDPDRDAAVIAHFGDGASSQGDVNESFVFAASYNAPVVFFCQNNQWAISEPFERQSRIPLYQRALGFGFPGVRVDGNDVLATYAVTQAALDRARDGQGPTFVEAYTYRMGAHTTTDDPTRYRLSDDLERWKLKDPIARVEAYLRRNGIADDAFFAGVQEEAADLGVRLREGCRALPDPSPLSIFDHVYTELTEELEQQREAFAAYLASFDGADFEGAH
>NC_008699.1|WP_011757934.1|4767873_4768854_-|alpha-ketoacid-dehydrogenase-subunit-beta
MTQKITLAKGLNMGLRKAMEDDPKVLLMGEDVGKLGGVFRITDGLQKDFGEDRVIDSPLAESGIVGTAVGLALRGYRPVVEIQFDGFVYPAYDQIVCQVAKMTFRSQGKSRMPMVIRIPFGGGIGAVEHHSESPEAQFAHTPGLKVVACSNPVDGYWMIQQAIACDDPVIFLEPKRQYHADKADLEETATPDPLFSSRVVRRGTDITVLAYGPTVKTAMAAAEAAATEGRSLEVIDLRTLSPLDMTPVYESVRRTGRVVVTHEAHVNLGLGAELAARITEQCFYSLEAPVLRVGAFDTPYPASRIEEDYLPDLDRVLDAVDRSLEF
>NC_008699.1|WP_011757933.1|4766437_4767862_-|2-oxo-acid-dehydrogenase-subunit-E2
MPEYKLPDPGEGLTEAEIVKWHVAVGDVVEINQVVVEIETAKSIVELPSPYAGEVSAILVAEGELVPVGTPIIAIGDDVAAEPAAGAAPEARAAAPVEIDLSNPAASGGGEGESLVGRNKADRGPVRRARKVTSGAMAAHMQAQAAFETGGAPMVEADEEPVPATAAAPLDAPAAVRTLAKPPVRKLAKDLGVDLTTLTPSGPNGTVSREDVEAAAGGDAVLGGRVAAGERGGESRPAEREWREPIKGVRKMMGQAMVQSAFTLPHVTEWVTVDVTATMELVERLKTRREFREVRVSPLLVLARAVMLAMRRTPEINSWWDDAAHEVVYKRYVNLGIAAATPRGLVVPNVKDAESMTLLELAQAINAVTATAREGKTQPAEMSGGTFTITNVGVFGVDSGTPIINPGESAILAFGAVRKQPWVVETDGQDTIVPRQICTLALAFDHRHIDGEKGSRFLADVAEIMADPATALLY
>NC_008699.1|WP_041546927.1|4765113_4766382_+|ArgE/DapE-family-deacylase
MPYRDLNDRELRALAFVDERELVRDLVELVSVPSISGSDAECDIQHRLAKQLGGLGLDVDLWQLDLDRLTADPAFPGWEAPRTESWGLVAASGPGEPELVLQGHVDVVPPGDLGAWGADPFGGTVTGRRVHGRGTCDMKAGVVANVAAVRAVRAAGIELTKPYAVQLVVGEEDGGLGAFATLERGHRGRACIITEPTSGTITTANAGALTFELRVPGAATHASTSYAGVSALEKFWPLHAALGELEARRNRDAHPLMAEYPLAYPLSIGKVACGDWASTVPDLLVAEGRLGVALGEDPDDARAELEEAIAEAACADLWLRDHAPTIAWTGGQFASGQYAEGSGALLDLVATAHADVTRGPRPRERGAPYGSDLRLYAAAGVPTLHYGPGDVRLAHGPHEAVDVDELVAVTESLVLALVRACA
>NC_008699.1|WP_011757931.1|4764108_4765080_-|DUF2804-domain-containing-protein
MAEREITAPVDLCLPGGRLNPDAVGWSRRPLHRANLRGWGRAKRWEYWGIVTPRLCLGVVASSLDYAGVCSVWVLDRATGRTWSRDEVPPLARGVSLPPGVGGRTLVEAGRLRIELADAPGGASGTVVRASAPGIEVDLVVGAGGECVGVVVPWSARRFQYTVKDVARPVTGRVVLEGTPYDVHAGWAVLDHGRGKWPYAITWNWAAGSSERVGITLGGQWTDGTGSTENALFVDGRAHKIGEQLTWEYDRSDWRRPWRIHGPRVDATLEPFHERVDRTNLGVVANQTHQCFGHWSGWASTDGGERVSLDGLVGWAEEARNRW
>NC_008699.1|WP_041546925.1|4763199_4764087_+|patatin-like-phospholipase-family-protein
MRVALALGSGGARGYAHIGAIEEIRARGHEIVAIAGSSMGALVGGLAAADRLEPYAEWARSLTQRDLLRLLDPKWSAPGAIAAGRFFAEVERLLGEQQIEALPIPFTAVATDLHARREVWFQRGPLVSAIRASTAIPGVITPVEMNGRLLADGGLMNPVPIEPTAVSVAELTIAISLQGARTAHERATPAREPAAPTWREELVERVRRTVGRSAEPEPEPEPPTLLEQVRLSDVVGLSMDAMQGLITRYRMAGLPPDVLVTVPVGAARSLEFHRAAEMIELGRTLTAEALDAAGR
>NC_008699.1|WP_041546922.1|4762359_4763178_+|SDR-family-oxidoreductase
MRTYAVSGAASGIGAATAGMLREQGHRVIGVDRVAADGVDVTADVSTPAGRAEAVAGVRALTDRVHGLVPAAGIAGRTGVDSQLVVSVNFFGAIALVTGLHTELTAGARDGGAGVVLLASNSITGMPGWNAPVAQACLRDDEPTAREEAGRVDSVLVYPATKAALAWWARREGVKPEWAGAGIRLNSVAPGATETPMVDQMRSDPLLGSAVDAYPTAIGRTGRPEEVAAAICFLLSEGAANIVGAVLFVDGGTDAMLHPVSPSGWEVGPIEP
>NC_008699.1|WP_011757928.1|4760738_4762232_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha/beta
MTTAPRPARLSAAELIDLVLDEGSWVSWDTPPDRTGVSPEYAAALDAAFDKSGADESVLTGEGRMRGRRVAVLMGEFAFLAGSIGRAAADRLVGSIERATREGLPLLAGPVSGGTRMQEGTPAFVQMVRITEAVAAHKAAGLPYLVYLRHPTTGGVMASWGSLGHVTVAEPGALVGFLGPRVYEALYGKPFPPGIQTSENLYAHGIIDAVVPPEEIAGILDRALEILLAPRHGIQPVPAPVPLTPLPEVETWDAVTRSRRPDRPGVRRLLKYAASDVIPLNGTGQGEQDPGLLIALVRFGQAPCVFLGQDRRGQTAEHPMGPEALREAQRGMRLASDLGLPLLTVIDTRGAALSAEAENGGMAGEIARCLNELITVTAPTLCLMLGEGNGGGALAFLPADRVIAAQHAWLSPLPPEGASAIVHRDLDHAPEMARSQQVRALDLRRLGIVDRIVAELPDAADEPEAFCRRVGAVLEHELAALLDAGPGTPAERARRYA
>NC_008699.1|WP_011757938.1|4772383_4773358_-|glutathione-S-transferase-C-terminal-domain-containing-protein
MGDDSRTGRGRYLTSGDFDRDMTYIPDRITKDGRRPEHGPVQGGLWPVEPGRYRLVAAKACPWATRSIIVRQLLGLEDVISMGLCGPTHDERSWTFDLDPGGRDPVLGIERLQEAYFARYPDYPRGITVPAVVDVPTGAVVTNDFPWITHDLFFEWRDHHRPDAPDLWPDDLREEMDQVMQRIFTEVNNGVYRCGFAGTQEAYDAAYDRLWTALDWLEERLADRRYLMGDRLTEADVRLFTTLARFDAVYHGHFKCNRNKLAEMPVLWAYARDLYQTPAFGENTDFDQIKAHYYVVHEDINPSKVVPKGPDPSVWLTPHGRDRL
>NC_008699.1|WP_041548293.1|4773408_4774425_-|glycoside-hydrolase-family-3-protein
MSLAQRVGQLFMVGTPADRVDRRTRAQIHRFHVGNVMLTGRSYDGVRAPARVSRAMRGEVDGRSTAGVRLFVATDQEGGQVRVLQGPGFSDIPSALEQGTWQPRRLRGAAKLWAGQLRRAGVNLDLAPVMDTVPSRRAARHNPPIGRYDREFGFTTKVVARHGVAFLNGMADGGVVPTAKHFPGLGRVHANPDTHAGVTDRVTTRHDAYLRPFGAAIDAGVPIVMMSTAYYEHLDPRNPAAFSPFVVGTMLRGDLGFRGVVISDDLARARQVAGFSPAGRALRFIGAGGDIVLSVDADPVGEMYRAVLERARTSERFRAKVDAAVLRVLRAKQDRHLL
>NC_008699.1|WP_011757940.1|4774594_4775665_-|histidinol-phosphate-transaminase
MTSPQPRRTVAAIPPYVAGKPPTVRPGMTSYKLSSNENPYPPLPGVIEAVQAGVAAMNRYPDMGSAALYAALSEKFAVPSDHLSVATGSVGLIYQLVQAFCEPGDEVVFAWRSFEAYPIAVTAAAATAVKVPVLADGRHDLDAMAAAVTDRTKVVLVCTPNNPTGPAVTQAELDDFLEKVPPHVLVVVDEAYLEFVRMADPVDGLATYRARENVVLTRTFSKAYGLAGFRVGYAVAPAPIAAALRAVSLPFGVSTVAQAAAIASLERQAELLERVEALVVERARVVAGLAEAGWDVPAAQGNFVWFELGERTADFAAAADEAGIVVRPFAGEGARVSIGETEANGRLLQVAAAFSR
>NC_008699.1|WP_041546931.1|4775674_4776256_-|VanZ-family-protein
MFPVGGVGVMLLLVVVSAAACLLLVVALGRRLGWVTAGSLGGLVWSLAVIASITLIPANGAPGIVPVEGRLTGCSWDVGGPAPDGFWIFSGGQRLLNTVVFVPPGALLVFAAARWRAAWVLVPAGLALLASYSAAIEGTQLALARLDRACDVTDVVDNVTGAVVGVGIGIVLAVLLRPWRRRPHRPAAREVRH
>NC_008699.1|WP_140404139.1|4776446_4776827_+|phage-holin-family-protein
MLTNAVALAVACQLFDGIGFRGGADSGWDEVADKIWPLLFVALILGVVNSFVSPVLKFLSIPFIIITLGLFLLVINALMLLFTEWLAGLFDIDFYVDGFWTAVGGAIVITIVTWIVGLLLGDAEEA
>NC_008699.1|WP_140404138.1|4776917_4777421_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MAQVVLTERVADAGLADRVTVSSAGTGDWHVGDPMDRRAAATLTRSGYDATRHRARQWTGRDPVDLVLAMDAQNHADITDLEDPAEDLAEDLAEDPAEDPAPAERAGRVRLFREFDPVEPGSDVPDPYYGGDSGFEEVLAMVERTAEALVQTLERERPWSGGGERVS
>NC_008699.1|WP_011757944.1|4777417_4778296_+|fructosamine-kinase-family-protein
MTRQPLVARRAEELLGSSVVATAPIAGGDISTATRLRLSDGTTALMKTLPHAPDEFFAEEAAGLRWLAEATPAGGAQVPEVLGVDHECVIVRWVEPGKNSVDAATAFGRALAATHAAGAPSYGRDRDGFIGRLPMPNRPTDTWAEFYAARRVLPYLKLARDRGAATAEQAAAIEAVLPRLADLVPEEPPARLHGDLWNGNVLWGLDGQAWLIDPASYGGHREVDLAMLALFGLPHLPRVLDAYAEATAGTTPLADGWADRVALHQVFPLLVHACHFGGGYAGRAAEAAARFV
>NC_008699.1|WP_011757945.1|4778372_4779077_+|response-regulator-transcription-factor
MTTPTAPRPRVLVVDDDKAVRESLRRSLEFNGYEVVLAADGAEALAGISAAAPDVVVMDVMMPRLDGLETTRALRTAGNDLPILVLTARDAVGDRVEGLDAGADDYLTKPFALQELLARLRALLRRVVPHEDATDEMLSFSDLSMDVGTREVRRGERVIELTRTEFALLEMFLRRPRRVLERSFILEEVWGYDFPTTANSLEVYVGYLRRKTEAEGEARLIHTVRGVGYVLKES
>NC_008699.1|WP_162094031.1|4779070_4780489_+|HAMP-domain-containing-protein
MVTVFPPVPPDGRWHYRRSLASRVTLLTTIAVGVTVAFVAAGAYLTVRMQMQTTLDDSLVERATTASLDLCQNDLHIPDEYLGAADVWVACLQGGIGVATSVDKSSPISLLGSPEAAVVGGERQQSLRTVVSKDGDTHWRVIALRRDGGQTMILAQSLESQQNVLNRLGIVMFLFGLAGVIAAGMAGWAVARNGLRPVRRLTSSVEQIARTEDLRPLPIEGDDEIARLATAFNQMLAALAASRDRQRQLVADAGHELRTPLTSLRTNLDLLGQADRGGVDLPSEARAELLDDVAAQIEEMTTLIGDLMELARDEPLTHVVEPVDVPELVDRAIARVRRRAAGVTFDVVAEPWFVVGESAGLERAVTNLLDNAAKWSPAGGTVRVRLAGGVLTVDDDGPGISEEDLPHVFDRFYRSQESRSMPGSGLGLSIVRQVAERHSGTVWAGAAPTGGARLTLWLPGSRAPVPDWTPAS
>NC_008699.1|WP_140404132.1|4780485_4781049_+|DUF3558-domain-containing-protein
MRRALPAAVLLAAGLLTAACSSGSAGSEADPGSAASDASAALSEATDVGWSPCDGLDAAQVSRFAAEPMAEQTGTTDQPRCAFTPVAEGGPAFDVNYLFFDGGLDEAWRTMGPIRGRVSRIAVPGADAARLVVHARRPAVLVTGFVQSGGLVQSVNAVQLRPYDEQQVVAATRRLLAALVRAAPERP

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Crispr_ID: NC_008699_33

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_33

4848570-4848655

Orphan

Consensus_repeat	Method
TTCCCCGGTGAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_33

>merge|NC_008699|33|4848570-4848655|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCGAAACTTCGGGGCAGAAGTTCCAACTTCCCCGGTGAACCGGGGAAACCG

>NC_008699|33|33|4848570-4848655|CRISPRCasFinder
TTCCCCGGTGAACCGGGGAAACCG	GAACTGTTGGGCCGAAACTTCGGGGCAGAAGTTCCAAC
TTCCCCGGTGAACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011758000.1\|4843959_4845966_+\|NADPH-dependent-2,4-dienoyl-CoA-reductase	unknown	unknown	gnl\|CDD\|239240
NC_008699.1\|WP_011758007.1\|4853654_4855295_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223539
NC_008699.1\|WP_011757999.1\|4843417_4843963_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_008699.1\|WP_011757996.1\|4840817_4841555_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_008699.1\|WP_011758012.1\|4859176_4860100_-\|diacylglycerol-kinase-family-lipid-kinase	unknown	unknown	gnl\|CDD\|224513
NC_008699.1\|WP_011757994.1\|4837728_4838460_-\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|181035
NC_008699.1\|WP_011758004.1\|4849970_4850900_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133022
NC_008699.1\|WP_011758003.1\|4848663_4849953_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372620
NC_008699.1\|WP_162094032.1\|4838468_4839614_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
NC_008699.1\|WP_011758010.1\|4856992_4858390_-\|beta-glucosidase	unknown	unknown	gnl\|CDD\|274539
NC_008699.1\|WP_011758006.1\|4852003_4853647_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|132997
NC_008699.1\|WP_049774493.1\|4856311_4856965_+\|sulfotransferase	unknown	unknown	gnl\|CDD\|379204
NC_008699.1\|WP_041546946.1\|4845989_4847138_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|224090
NC_008699.1\|WP_049774494.1\|4858405_4859068_+\|pirin-family-protein	unknown	unknown	gnl\|CDD\|380375
NC_008699.1\|WP_011758002.1\|4847230_4848553_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NC_008699.1\|WP_011758005.1\|4850904_4851993_-\|sulfotransferase-family-protein	unknown	unknown	gnl\|CDD\|226081
NC_008699.1\|WP_041546944.1\|4841551_4842403_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_008699.1\|WP_011757998.1\|4842399_4843293_-\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270248
NC_008699.1\|WP_086000443.1\|4839810_4840719_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011758008.1\|4855294_4856287_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379276

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011758000.1\|4843959_4845966_+\|NADPH-dependent-2,4-dienoyl-CoA-reductase	gnl\|CDD\|239240	cd02930, DCR_FMN, 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the flavin and iron-sulfur cofactors. Metabolism of unsaturated fatty acids requires auxiliary enzymes in addition to those used in b-oxidation. After a given number of cycles through the b-oxidation pathway, those unsaturated fatty acyl-CoAs with double bonds at even-numbered carbon positions contain 2-trans, 4-cis double bonds that can not be modified by enoyl-CoA hydratase. DCR utilizes NADPH to remove the C4-C5 double bond. DCR can catalyze the reduction of both natural fatty acids with cis double bonds, as well as substrates containing trans double bonds. The reaction is initiated by hybrid transfer from NADPH to FAD, which in turn transfers electrons, one at a time, to FMN via the 4Fe-4S cluster. The fully reduced FMN provides a hydrid ion to the C5 atom of substrate, and Tyr and His are proposed to form a catalytic dyad that protonates the C4 atom of the substrate and completes the reaction.	0
NC_008699.1\|WP_011758007.1\|4853654_4855295_-\|hypothetical-protein	gnl\|CDD\|223539	COG0463, WcaA, Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane].	1.5354e-06
NC_008699.1\|WP_011757999.1\|4843417_4843963_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.40699e-18
NC_008699.1\|WP_011758004.1\|4849970_4850900_-\|hypothetical-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	1.57822e-05
NC_008699.1\|WP_011758012.1\|4859176_4860100_-\|diacylglycerol-kinase-family-lipid-kinase	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	1.78603e-50
NC_008699.1\|WP_011757994.1\|4837728_4838460_-\|glutamine-amidotransferase	gnl\|CDD\|181035	PRK07567, PRK07567, glutamine amidotransferase; Provisional.	3.97879e-138
NC_008699.1\|WP_011757996.1\|4840817_4841555_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.07102e-135
NC_008699.1\|WP_011758003.1\|4848663_4849953_-\|hypothetical-protein	gnl\|CDD\|372620	pfam13506, Glyco_transf_21, Glycosyl transferase family 21. This is a family of ceramide beta-glucosyltransferases - EC:2.4.1.80.	0.00536562
NC_008699.1\|WP_162094032.1\|4838468_4839614_-\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	1.81697e-107
NC_008699.1\|WP_011758010.1\|4856992_4858390_-\|beta-glucosidase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	0
NC_008699.1\|WP_011758006.1\|4852003_4853647_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|132997	cd00761, Glyco_tranf_GTA_type, Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold. Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.	2.91385e-16
NC_008699.1\|WP_049774493.1\|4856311_4856965_+\|sulfotransferase	gnl\|CDD\|379204	pfam13469, Sulfotransfer_3, Sulfotransferase family.	6.5117e-08
NC_008699.1\|WP_041546946.1\|4845989_4847138_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|224090	COG1168, MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism].	3.83724e-110
NC_008699.1\|WP_049774494.1\|4858405_4859068_+\|pirin-family-protein	gnl\|CDD\|380375	cd02910, cupin_Yhhw_N, Escherichia coli YhhW and YhaK and related proteins, pirin-like bicupin, N-terminal cupin domain. This family includes the N-terminal cupin domains of YhhW and YhaK, Escherichia coli pirin-like proteins with unknown function. YhhW is structurally similar not only to human pirin but also to quercitin 2,3-dioxygenase (quercitinase). Although the function of YhhW is not completely understood, YhhW and its human ortholog have quercitinase activity and are likely to play an important role in transcription and apoptosis. This N-terminal cupin domain of YhhW has a metal coordination site and is thought to have catalytic activity while the C-terminal cupin-like domain has diverged considerably and has closer alignment with C-terminal pirin. YhaK is found in low abundance in the cytosol of E. coli and is strongly up-regulated by nitroso-glutathione (GSNO). There are major structural differences at the N-terminus of YhaK compared with YhhW; YhaK lacks the canonical cupin metal-binding residues of pirins and may be involved in chloride binding and/or sensing of oxidative stress in enterobacteria. YhaK showed no quercetinase and peroxidase activity; however, reduced YhaK was very sensitive to reactive oxygen species (ROS). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	2.33856e-50
NC_008699.1\|WP_011758002.1\|4847230_4848553_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	7.26349e-179
NC_008699.1\|WP_011758005.1\|4850904_4851993_-\|sulfotransferase-family-protein	gnl\|CDD\|226081	COG3551, COG3551, Uncharacterized protein conserved in bacteria [Function unknown].	1.44482e-18
NC_008699.1\|WP_041546944.1\|4841551_4842403_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.45549e-55
NC_008699.1\|WP_011757998.1\|4842399_4843293_-\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270248	cd13530, PBP2_peptides_like, Peptide-binding protein and related homologs; type 2 periplasmic binding protein fold. This domain is found in solute binding proteins that serve as initial receptors in the ABC transport, signal transduction and channel gating. The PBP2 proteins share the same architecture as periplasmic binding proteins type 1, but have a different topology. They are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the family includes ionotropic glutamate receptors and unorthodox sensor proteins involved in signal transduction.	5.65275e-53
NC_008699.1\|WP_011758008.1\|4855294_4856287_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379276	pfam13578, Methyltransf_24, Methyltransferase domain. This family appears to be a methyltransferase domain.	9.97958e-11

>NC_008699.1|WP_011758002.1|4847230_4848553_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MPGQRVTVIGCGYLGATHAACMAELGYEVLGVEIDAAKRESLAAGKVPFYEPELEELLAKHVTSGRLRFTDSYEEAGAFGAIHFVCVGTPQRHDALGADVRYVDAAVESLAPYLVESALVVGKSTVPVGTAERLAARLAALAPAGAEARLAWNPEFLREGFAVKDTLEPDRLVFGVASERDEQELRSFYSSVIEAGTPVVVTDFATAELVKVSANAFLATKISFINAVAEVCEAAGGDVVDLADAIGHDARIGRKFLNAGVGFGGGCLPKDIRAFLHRAGELGVEDTMSFLRQVDDINLRQRTRVVQIATTMLGGSVARARIAVWGAAFKPHSDDVRDSPALSIAGQLHLRGAQVSVYDPKANDTARATFPTLDYAESALAAARDADLLLHLTEWPEFRSVDPAELGAVVRRKQLVDGRNVLDLAAWRAAGWTARGLGRR
>NC_008699.1|WP_041546946.1|4845989_4847138_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MTRQLIRDLTDDQARSAFPLKWGAVEPGVVPGWVAEMDYRPAPPIEEALVATVRQGALGYAAFGDGGLGEAFAGFAKRHWDWSVPAESVLPTGGVMGGIRLALEALCPPGPVVVPLPCYPPFRDAVAITGRELVTVTVDPDADEAVLDLAAVEAAFAAGTRTFLLCNPHNPLGRAWSREELTELAELARRYDVRVVSDEIHAPLVLAGATFTPYLTVDERAVVVTSASKSFNVPGVHGAQLVLLDAADRAVFAGLPVPAQNSWSSLGIVAGVAAWRDGDEWHAALLERLTAQRALLGDLLATRLPRARMRPLEATYLAWLDLRAYGVDDPAAAGLAHGVRLAPGSDYQPGLDGHVRLNLATNADRLELMVHRLATALTSRNS
>NC_008699.1|WP_011758000.1|4843959_4845966_+|NADPH-dependent-2,4-dienoyl-CoA-reductase
MTYPHLLEPITLGPLTLRNRVVMGSMHTGLEDRPRDLTALAAYLAERARGGVGLIVTGGYAPNRRGWLKPFAAEMTTRLQAMRHREITGAVHDEGGAIALQVLHAGRYGYHPFSVSASGRKSPITPFRPRALSTKGVDRTATDFAHSVALARKAGYDAVEIMGSEGYLINQFLAARTNDRTDAWGGTAARRMRFPLEVVRRSRELVGDDFPIVYRISLLDLVEGGQAWDEVVELAHGLEQAGITVLNTGIGWHEARVPTIITQVPRGAWRSATARLKAEVSVPVCASNRINTPELAEEILAAGEADLVSMARPLLADPDFVAKAAAGRADEINTCIACNQACLDHVFANRKASCLVNPRACRETTLVLTPTRTRRTVAVVGAGPAGLAAAVSAAERGLAVTLFERSAEIGGQFRLAMRVPGKEEFAETLRYYARRLEVLGADVRLGTTASAADLAAYDEVVVATGVAPRVPELEGVDHPKVVSYADVLSAAVVPGRRVAVIGAGGIGVDVSHFLTHDPADTDEDWRAHWGVGDPALHPGGLTERKPRAPVREVTLLQRKTTPIGIGLGKTSGWAHRAVLRQSGVVQVSGTTYGRVDDAGLHITVDGEQRVLDVDHVVLCAGQESVRGLYDELVDRRPGGLHLIGGADVAAELDAKRAIEQGTRVAAAL
>NC_008699.1|WP_011757999.1|4843417_4843963_+|PadR-family-transcriptional-regulator
MALEHALLVALREQPASGLDLAKRFDRSIGFFWHATHQQIYRVLARMDADGWVRVTTVEQTGRPDKKVYDVTPAGAEVLGSWLAAPSEAEPLRSELAVKLRGASFGDRDAVLEVVRGNLADHRLRLDHYRGLMARDYPRPDELRDPLELDQYLVLRGGILLEEMWIAWLTEYLDRHDKARR
>NC_008699.1|WP_011757998.1|4842399_4843293_-|amino-acid-ABC-transporter-substrate-binding-protein
MRLRGSLTIAALPLLLAAAACAPESDGGPTTASDPAASDTAGSSAPADQCAKESLPLVSEHPMLTIGTDSPAYEPWFVDNDPTNGKGFESAVAYAVAEQLGFSADEVMWVKVPFNNSYAPGPKKFDFDINQISITPQRAEVVDFSDGYYSAAQAVITLKKDGATPTSLADLAGLKLGAQTGTTSLTAIRDQIQPDSDPLVFQNTNAAKQALLNGQVDAIVADLPTAFYITAVEIPGSTLAGQFQFSGEQEQFGMLFEKGNPLVTCVDEALAALKSDGTLAGIEQQWLSDTVDVPVLE
>NC_008699.1|WP_041546944.1|4841551_4842403_-|amino-acid-ABC-transporter-permease
MSAVDRTPSERERERARVRRSIRRRGVLLATAATVVVLGLLVVGLTSSPGWPRVRETFLSWPDAKESFPDIAKGFWLNVKMFLAAEPLILLLGGAVAIVRSTVSPLLTPIRLLAVVYTDFFRGVPTILVVFLFAFGIPALGLQGVPNDLAVLGTAALVLSYGAYVAEVIRAGIDSVHPSQVASAEALGLSRAQAMRFVVLPQGVRRVVPPLINDFVSLQKDTALVGAVGVFESLFAAQDYGNFNFNYTPYLVTAAFFVALTIPIARFTDWMGRRMMERERGSR
>NC_008699.1|WP_011757996.1|4840817_4841555_-|amino-acid-ABC-transporter-ATP-binding-protein
MSALLEITGLRKSYGDKVVLDDVSLAVAPHDVICLIGSSGSGKSTLLRCLNLLEDIDDGVIRFEGAEISDPRVDARAVRKRIGMVFQAYNLFPHLTVLDNCTLAPRQVHGVRRADAEARARELLERFGLADQAAKHPDKLSGGQQQRAALVRALCTHPTLLLLDEITAALDPELVGEVLEIVRAEAERGMTMVLATHEMAFARDVATRVCFLDQGRILEQGPPAEIFSNPREERTRHFLRRVLPG
>NC_008699.1|WP_086000443.1|4839810_4840719_+|hypothetical-protein
MVSRAQVVACGGAPHDLGRLVRRRELVRVLPGVFVDHTGRPTWLQRAWAGCLYYEPAALAGPSALRAVSGPGWRHHDDSGPVDLALDVSRRCVDAPGYRVRRVTGLAAKVQWNMSPPRIRVEEAALDEALRQPSRFAMIGVLADICQSRRTTAHRVLEAAGERGRLTDRSLLCGVLADIADGTCSTLEHAYLDLVERAHGLPVGRRQQPGSSERSGVLRDVDYDPLLFLVELDGRLFHDTSGQRDRDLDRDLDAAVDGRRTVRLGWGQVIDRPCRTAARVAALLARAGWTGTPTRCGPDCRL
>NC_008699.1|WP_162094032.1|4838468_4839614_-|CoA-transferase
MGQGTGPLRGVKVVEIAGIGPGPHACMTLADLGADVIRVERPGGQLLAGGGPHMFLNRGRPSVALDLKHPDAIRTVLELVAGADVLVEGMRPGVAERLGFGPEVCHERNPRLVYGRMTGWGQDGPFAQVAGHDLNYISITGALHGLGQDKARPHFPGNLLGDFGGGSTYLVIGVLAALLEARASGQGQVVDAAIVDGTAHLNTMAAAFLAAGTFKEERAANLLDGGVPYYDIYETADGKHMSVGALEPQFYDEFVRLLGIADRAPDRYDADRAEALRTLIADTFRTRTQAEWVELFEGTDACVAGIIPLTEAAEHPHMRARGVLVERDGYLQPAPAPRFSRTAATLGRTAEDAGQSTREALAAWGVTGVEALLESGAAVQG
>NC_008699.1|WP_011757994.1|4837728_4838460_-|glutamine-amidotransferase
MKPFLFLGTRAEDEAADSEYAAVLRCAGLEERDVRRIRVERDELGPVDLDGLSGIVLGGGPFNSSDPDQTKSPVQRRAEADLRRLAEQVLDADFPFLGACYGVGVLGGLRGGLVDRTYGEPISSRRITLTEAGMLDPLLGAMPPAFDAFLGHKEAVARLPVGAVLLASSDTCPVQAFRMGSNVYATQFHPELDGDGLALRIETYRHHGYFEPDELDGLLAMARGSTVEHPPRLLARFVALYAR
>NC_008699.1|WP_011758003.1|4848663_4849953_-|hypothetical-protein
MAERRTEVRVADLLALRSYDGPADERSAVVRVLVESAPGALALVPRPEWPPLTSLRSRRAEGGWLVVARFARPVAVAEVVSELGRQAVWPVVVAVREDPARLDERLFNPIGFRSAWERGVVALGSAPLTPSLVAELRDAQGVAVGPDADPRTVAGLAMAGVPLTGAGFDEVDLDDPLAREEHSLVLRRAALDAHGSIDWQRPVSVLLATRRPEQLDFALAQVARQRGVAALQLVLAPHGFTVDEAWVRAAVGPAVDVRLAPASADTIFGDVLHAAAGVADGDVLLKMDDDDWYAPDVVTDLLRARAYSGAQLVGMPAEFHYVAPRDLTVKRGHPTELYARFVAGGTMLVDRPVLREVGGFRSVRRYVDAQLLTAVTAAGGAIYRTHGLGYVLRRNESGHTWEVDLDYLLDPSRVERSWTGLTPSRLMEL
>NC_008699.1|WP_011758004.1|4849970_4850900_-|hypothetical-protein
MGRATTGPDIPNREGERAYDVTWPWREGPLRPGLTCVFRVRNEARNLPWVLPPMFEAVQHVVLVDNGSDDGTPEVAQRVAEQVGAADRFTLTAYPFRVSRAGAEHLATPPDSVHSLTHFYNWSFSQVRTSYSMKWDGDMVLTREGVATLADLSWQLEDSRAVVAVPRHPVSIESESVAWIDLGFRFLEPWIYPMGPEYTFVKAFEWEVREFPEGSERIILPEGLCVELKWLDADEFAHWSHTEFDSSRAPRKRREWEVYSALCEGRGERVEGLHRIEAPPGVHVVDHITRTWLPRVPRPLVQRRGRLDV
>NC_008699.1|WP_011758005.1|4850904_4851993_-|sulfotransferase-family-protein
MPGHPSTPIPLSEPIPVKRRVVFVVGSGRSGTSTMSGALQTLGMHVPQPEVVADETNPKGFGEPQWVVDFHDELLKRCNVQVSDARPAAWFLAGKLSAFEPLRGRLHEWLEEQFVEGGPELVVKDPRLAWFLGLWRAAALRCDAAPAYVTMLRPVTEVVGSKQKYYAAAKAGAAAGEVQRTAAWVNMMLHTERSTRGSARRFVRYDDMLKDWTIPVFGIGQAFDLDAVQSATANDIRRVHQFIDPSLRRVQLTWDDVEVPGRLREIAEETWQHLDRLADEDGDTPDVHDRLDELRTAYAALYDEAEALSHSTALAARREGQAQAPSGALVPARLADRVPHGVRAMVPAGARRGLRKAFGKER
>NC_008699.1|WP_011758006.1|4852003_4853647_-|glycosyltransferase-family-2-protein
MSDQPRVRRNDWGTLDAPALGRWEPTRSVSVVIPAYGAQRLLPYVLAGLAAQTYPAHLLEVVVADDDPARPLELSELTGPRPERTRIVRVETGWGRANACHTGALAADGEVLHWLDADMLVEPEEVEAQLRWHHLIDHAVVLGHKWFVDPDSLLARDPDASGRMHEVFATAEKERHWVEDVWDRTDDLRTAGPRALRTHVGATASLRRTLYDEAGGMDTGLRLGEDIDLGYRLAECGAVFVADREARSWHLGRSHQQSRQEEVNDYNTHFLADRVPDLQPQRRRGRLYSVPYLEVVLDTRGLDHTAVIATVDSVLGSSLTDLSVTLLGDWSRITEERTHPLDDEQRAPRLVRAAYAGEPRVLLAESSGRRRGQFRLVLANADWAPTPETLGTLVLHLERTHHGLRQVLMADGSVARVERTAAYARAAKVAGPEGNPADPERLDDLVDELFGSWWVEGGDAGFEPSVTIKRPRLRGTAGPAQDPAESWRELGGTGGGSPQQKGRRAGAQQGKQAAQQAGQPAQPEPRRQAPARPGRSRIGSLLRRGRR
>NC_008699.1|WP_011758007.1|4853654_4855295_-|hypothetical-protein
MLADLAAPALVLVGPGVDLATGSGPVPEGVTRVALGDEVPDGVWASVLLAVADEAALRVAVSRLPRLGRTKHVGCHLASATGPVTTVLRPEWPPLANLVAETADGGAHTRLTFRRPAPAGPVLVELARHTGTRVVTGNHGLVVTGAPVPVDPTAVTDEVPAAVVVGGRADLPEHPVLGRAPVALHLRGEPAGPLDEAPLDEALLNPVGFRRDWDRGPVPLPAGDPTPELVAAVRDAQAVVVPDDADPRTVAGLAMAGVPLLGAGYPGIDPVDPADLDDPLRREEHSVRLRRAALREHSHLAWRHRVARRAGLRAAAYPSVSVLLPTRRPEQLAFALDQVARQRGVAELELVLATHGFEADPGLVRERLGERPVTLLPLPADTVFGDVLRAATDAATGDVVVKMDDDDWYGPDLLADLLLAKHYSGADLVGTPAELVYLEPIRTTVRRRGPSESFGAVVAGGTMTLDRALLRAVGGFRSVPRHVDARLLEDVRAAGGSVYRTQGLGYVLRRTTHGHTWDTGLGYFLTRQSVAAQWRGFRPSRLLEAG
>NC_008699.1|WP_011758008.1|4855294_4856287_-|class-I-SAM-dependent-methyltransferase
MSAARLRLAALVVALLLVAAPVVFGLVDGRTGVLVGLALSGAVAATGVCGYVVLRRVEERLRGLERGIARAQRPDRQPGRPGRPGQPGKQGKQGNQGRRGRGAARPQLPKGLVTQAHLKKERDQVAKRVQDITNLFDMVPIRAGIPPLGLWTASADLLVALVDRFVETRPATVVEGGSGVSTVVLALAAREHGIATRIVALEHDPDWADSTRRLLARHGVAEYAEVRVAPLGPTSLPDHHTPWYDESALADLSEVGLVLVDGPPEGTGPRARYPMVPLLRDRLARTCTIVVDDTSRPGDADVVDRWRPLLPDFEFETLRLDKGAAVLTRT
>NC_008699.1|WP_049774493.1|4856311_4856965_+|sulfotransferase
MPRSDLRYLFVVTYGRSGSTLLMGVLNTLPGYLIRGENRDALHHLFLFDKTMRTESGRGPRKKLRQPTHPFFGIAGYPPERAVRQLRRLATDTVLRPKEDTRVTGFKEIRWYHADLEEYVAWLREVFPGARFLVNTRNHADVLKSKWWAEGEDKSAHLADIERQILALADSLGDAAYRVHYDEYVADPAALRGLFDWLGEDFDEDAVRATMAVRHSI
>NC_008699.1|WP_011758010.1|4856992_4858390_-|beta-glucosidase
MPPASPDSSPGSRSGSPAGSSLPQLPPGFRFGTSTASYQIEGAATEDGKGPSVWDTFTAEEGRIVDGSSGAVACDHYHRYGEDVALMKRLGAGGYRFSLSWPRIQPTGSGPANPKGLDFYDRLIDELLANGVQPMATLYHWDLPQALEDDGGWLNRATVDRFAEYAAIVGERFADRVEHWIPVNEPNVVMMMGYAVGFQAPGRTLMFDSMPVAHHLLLAHGRAAVELRAAGATSIGCANNHSPMWPASDDEADVGATKLFDALWNGMFTEPMLLGRYPADLQPLMADVVCDGDLSVIRQPLDFYGVNYYHPFKIGAAREDAEMPFEFRELVGYPTTDFGWPVVPDALREWLITLRARYRAALPPIYITESGCSYNMGPDEFGVVDDQPRIDYLDAHLRAVATACQRGVDVRGYYTWSLMDNFEWSEGYTQRFGLVHVDFDTQVRTPKRSFQWYADVIARQTRSVG
>NC_008699.1|WP_049774494.1|4858405_4859068_+|pirin-family-protein
MSVEIRRGTDRYLTRGAGFFTRHSFAFGEHYDPDNVSFGPLVCHDDHRLGAGAGFESHPHRDLEIVTWVLSGALRHEDSAGHSAVVTPGVVQVLSAGTGVTHSELAGPDGPVRFVQAWLTPEEPGTPPAYSARAVELEPGRLVDVVRVGAATLRVARLGAGDTVILPEEPRQHVFVAGGALTRSSLAEPLADGDAFRIVDQPGLAVTAAVPTELMVWSFG
>NC_008699.1|WP_011758012.1|4859176_4860100_-|diacylglycerol-kinase-family-lipid-kinase
MSAPESRRAFTFLVNPSSGGGAAPEAVVPVARLLREGGATVDVTYSPGPHAMVELVDQAVGRGDVVVSVGGDGMLSSLAGLVSERGGVLGVLPAGRGNDFARMLGLPEDAEGQARLLLEGAVRHVDLIAVTGLGRARRVVAGSVYAGVDARATEIVDRATWLPRRLQYPYAALRSLATYQAGRYVVAVDGIEHTYTAATVVVANSGYYGSGMKIAPAASVEDGRLDVVVIEAASRVALMRSLPKVYDGSHVALPEVTVLTGTRVELRGTSRSAIPVGGDGEPLGPLPTLDAAPAAVEILPGALAVLA

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Crispr_ID: NC_008699_34

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008699_34

4872953-4873037

Orphan

Consensus_repeat	Method
TCCCCGGTTAACCGGGGAAACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008699_34

>merge|NC_008699|34|4872953-4873037|CRISPRCasFinder
TCCCCGGTTAACCGGGGAAACCGGAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAACATCCCCGGTTCACCGGGGAAACCG

>NC_008699|34|34|4872953-4873037|CRISPRCasFinder
TCCCCGGTTAACCGGGGAAACCG	GAACTGTTGGGCCGAAACTTCGGGCCAGAAGTTCCAACA
TCCCCGGTTCACCGGGGAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008699.1\|WP_011758015.1\|4862290_4863862_+\|glycerol-3-phosphate-dehydrogenase/oxidase	unknown	unknown	gnl\|CDD\|223651
NC_008699.1\|WP_011758031.1\|4882599_4884243_-\|sodium:solute-symporter	unknown	unknown	gnl\|CDD\|223664
NC_008699.1\|WP_011758014.1\|4861691_4862294_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_008699.1\|WP_041546952.1\|4873045_4874941_-\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|274573
NC_008699.1\|WP_011758032.1\|4884239_4884551_-\|DUF3311-domain-containing-protein	unknown	unknown	gnl\|CDD\|371707
NC_008699.1\|WP_011758026.1\|4878810_4879098_-\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011758025.1\|4876867_4878700_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_008699.1\|WP_140403862.1\|4863948_4865022_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236196
NC_008699.1\|WP_011758024.1\|4875021_4876791_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|236941
NC_008699.1\|WP_011758022.1\|4870832_4872938_+\|elongation-factor-G-like-protein-EF-G2	unknown	unknown	gnl\|CDD\|237186
NC_008699.1\|WP_158305699.1\|4879349_4879487_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_011758013.1\|4860096_4861653_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NC_008699.1\|WP_011758028.1\|4879667_4880258_+\|YceI-family-protein	unknown	unknown	gnl\|CDD\|377274
NC_008699.1\|WP_011758021.1\|4868867_4870325_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143421
NC_008699.1\|WP_140403852.1\|4866787_4867696_-\|DUF2332-domain-containing-protein	unknown	unknown	gnl\|CDD\|378386
NC_008699.1\|WP_140403851.1\|4867820_4868813_+\|hypothetical-protein	unknown	unknown	unknown
NC_008699.1\|WP_049774497.1\|4881302_4882571_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NC_008699.1\|WP_011758029.1\|4880363_4881290_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|132489
NC_008699.1\|WP_011758018.1\|4865656_4866667_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NC_008699.1\|WP_011758017.1\|4865023_4865587_+\|TIGR03086-family-protein	unknown	unknown	gnl\|CDD\|274424

Protein	Function_ID	Function_description	E-value
NC_008699.1\|WP_011758015.1\|4862290_4863862_+\|glycerol-3-phosphate-dehydrogenase/oxidase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	4.9998e-123
NC_008699.1\|WP_011758031.1\|4882599_4884243_-\|sodium:solute-symporter	gnl\|CDD\|223664	COG0591, PutP, Na+/proline symporter [Amino acid transport and metabolism / General function prediction only].	8.6347e-61
NC_008699.1\|WP_011758014.1\|4861691_4862294_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.73791e-07
NC_008699.1\|WP_041546952.1\|4873045_4874941_-\|penicillin-binding-protein	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	1.07636e-61
NC_008699.1\|WP_011758032.1\|4884239_4884551_-\|DUF3311-domain-containing-protein	gnl\|CDD\|371707	pfam11755, DUF3311, Protein of unknown function (DUF3311). This is a family of short bacterial proteins of unknown function.	7.94937e-14
NC_008699.1\|WP_140403862.1\|4863948_4865022_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236196	PRK08241, PRK08241, RNA polymerase subunit sigma-70.	4.9621e-169
NC_008699.1\|WP_011758024.1\|4875021_4876791_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|236941	PRK11634, PRK11634, ATP-dependent RNA helicase DeaD; Provisional.	0
NC_008699.1\|WP_011758022.1\|4870832_4872938_+\|elongation-factor-G-like-protein-EF-G2	gnl\|CDD\|237186	PRK12740, PRK12740, elongation factor G-like protein EF-G2.	0
NC_008699.1\|WP_011758029.1\|4880363_4881290_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|132489	TIGR03448, mycothiol_MshD, mycothiol synthase. Members of this family are MshD, the acetyltransferase that catalyzes the final step of mycothiol biosynthesis in various members of the Actinomyctes, Mycothiol replaces glutathione in these species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	3.2357e-12
NC_008699.1\|WP_011758013.1\|4860096_4861653_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	6.533e-61
NC_008699.1\|WP_011758028.1\|4879667_4880258_+\|YceI-family-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	4.0167e-58
NC_008699.1\|WP_011758021.1\|4868867_4870325_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	gnl\|CDD\|143421	cd07103, ALDH_F5_SSADH_GabD, Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like. Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.	0
NC_008699.1\|WP_140403852.1\|4866787_4867696_-\|DUF2332-domain-containing-protein	gnl\|CDD\|378386	pfam10094, DUF2332, Uncharacterized protein conserved in bacteria (DUF2332). Members of this family of hypothetical bacterial proteins have no known function.	4.41797e-70
NC_008699.1\|WP_011758025.1\|4876867_4878700_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_008699.1\|WP_049774497.1\|4881302_4882571_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	1.21053e-132
NC_008699.1\|WP_011758018.1\|4865656_4866667_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	1.97616e-16
NC_008699.1\|WP_011758017.1\|4865023_4865587_+\|TIGR03086-family-protein	gnl\|CDD\|274424	TIGR03086, TIGR03086, TIGR03086 family protein. This family, like pfam07398 and TIGRFAMs family TIGR030834, belongs to the larger set of probable enzymes defined in family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized.	3.29635e-15

>NC_008699.1|WP_011758022.1|4870832_4872938_+|elongation-factor-G-like-protein-EF-G2
MAEKGGGNRRASGQDLAASSPDRIRNVVLVGPAGSGKTTLAETLLAASGAIPRAGSVRDGTTVSDHEESEHAHGRSNSLSVAPLVHEGVKVNLIDTPGYADFVGELRAGLRAADCALFVIAANDGVDDATRALWRECAAVGMPRAVVVTKLDQARADYDGVLRQAQDAFGDRVLPLYVPVRDGADVTGLTGLLTPGAEAEATGLRGDLIEAVIEESEDETLMERYVGGEEIDEKVLVQDLERAVARATFYPVVPVCSMTGVGCQELLDLAVRAFPSPAEHISPDVFLPSGAAADPISCDPDGPLVAEVVKTASDPYVGRLSLVRVFSGTLEPDQTVHVSGHFSSFFGEGGGHPDHDEDERIGNLGHAFGKLQVPTDRVVAGDLCAVGRLSRAETGDTLSAVDQPRVLRPWSMPEPLLPIAIVARSKADEDKLSQALGRLAAEDPSLRIENNAETHQLVLWCMGESHAEVTLERLTERYAVHVDQVPFVVSLRETFAGKGAGLGRHVKQSGGHGQYAVCQIEVEPLPEGGGFEFVDKVVGGAVPRQFIPSVEKGVRAQMERGVRHGYPVVDLRVTLLDGKAHAVDSSDMAFQMAGGLALREAAAATTVTMLEPYDTVTVVIPDDLVGTVMSDLSARRARLLGTDKVGDDRTQVLAEVPQTELVRYAVDLRSATHGAGVFTRSFAHYEPMPEEVARNVETRTT
>NC_008699.1|WP_011758021.1|4868867_4870325_-|NAD-dependent-succinate-semialdehyde-dehydrogenase
MNGLDLLGPTQRGLLIGGTWRDAEGGKRLDVIDPADGSVLTDVADGSVADAVDALDAAVAAQADWAATPPRQRGELLRTAFELIIERSEQFAHLMSLEMGKTVAEAAGEVTYGAEFFRWYAEEAVRIHGRWMQAPGGGSRLLTIKKPVGPCLFITPWNFPLAMGTRKIGPAVAAGCTMVVKPASQTPLSMLALAAVLEEAGLPAGVLNVVTTSHTGEFSETLQADDRLRKVSFTGSTGVGRVLVRQSADRLQRVSMELGGNAPFLVFEDADVDAAVDGAMVAKMRNMGEACTAANRFLVHASVADDFAEKLGKRMGALSLGRGQDDGVDVGPLIDERAVESVSQLVTDAVHDGATVVTGGRPVDGPGYFYPPTVLLGVPADSEINVQEIFGPVAPITTFDSEADAIRMANDTEYGLASYVYTRDLARTIRLAEALEFGMVGVNTGLISNPAAPFGGVKSSGFGREGGFEGIEEYLETTYVALPAG
>NC_008699.1|WP_140403851.1|4867820_4868813_+|hypothetical-protein
MGTFGGRRAVAHASALLVLPVLLVASLLAGCTAALDQAHSVQTKLGRIDQIADATVSTPSHERAAAITISYTGVTTARELARLLDDVARVADDEQYPAYRLDLAPADSPGDTLVVDSTFIDSDVVSAVLTTWFRVTASLLGDVTYSYQPGNESIAVDAGAAVAHDVSEASRIGYGFRDTTWTFTNAGTVFVASGRVSPTDVLLFSGVQRSVSSAALPAPAPTWRLERRTDHLLLDLDVTFASEPVAAARLTIERYGDDVQRLVVAALGAVRVAGLPVWLRLHHRADTAGGGTPQDDVFGYWVAGHNPVRGRDPMLRGWDRWLAALARATR
>NC_008699.1|WP_140403852.1|4866787_4867696_-|DUF2332-domain-containing-protein
MLRGLVAADEELLAWLATLPLTKRQPNLVLAAARWHGVPAPGPYAALREALLRDDGTIRRTILDRATQTNEAGRLATLVPAFALAAGAGPVALVEVGASAGLCLFPDRYRYAWRTASGVHRVGDPAAPELACAVLGDGPLPDGPPEVVWRAGIDLAPVDVTDDDQVRWLAALVWPEHDDRRARLERAVEVARADPPYLVRGDLLEELPALVDRAREHAPVLVFHSAVVAYLPEERRTAFHDLMTGLVAAGRCHWVSNEGPRVLPAVTATGPAVPEDEHGFVFGVDGRAVARTHGHGRSLRWF
>NC_008699.1|WP_011758018.1|4865656_4866667_+|helix-turn-helix-transcriptional-regulator
MLPTRVDLAARGYAMARAGRIGEALADLEQLRATGWDDLDDLDRASVLTTAVDCRLARGDLSAAMALGETLGGFLDRPGLTGAVAHHGRGELSAAAGDSDLAAGHFTRAGRLLAGGTGDIGPGDIGPGDIGLVPWRVGAALAAVRLGRRREGAALAREHLGAARSSCSPYAVAVALRTMATVDAGSDRTALLREARDVLAGVPAARLAAQIDTDLAGLLLLSGRPDAAAALGLLRAAEAYAGREELWPLQSRVRRLLDRMGEPARPVHGEALAALTAAERRVARLAADGLTNRQIADRLVVTVKAVEWHLSHIYRKLGIRSRTGLPASLGLEAAAL
>NC_008699.1|WP_011758017.1|4865023_4865587_+|TIGR03086-family-protein
MTQTLPGSVELLDRALGYTRARLAVVHSELLCRPTPCEGWTLADLLAHLEDGLDTFTEAAGGAVEVRGGSTAAGRLDSLRDKACALLAAWSEPTPGDVVIETAGAHVDLAAPTLVATAALEVTVHGWDVGQSTGERAAIPANLAQHLLPIAHRLVGAGDRGARFKRARPVPAMAPYDQRLLGFLGRT
>NC_008699.1|WP_140403862.1|4863948_4865022_+|sigma-70-family-RNA-polymerase-sigma-factor
MTTHPQTDTPTEGRTAAARSELGDFPTLTQRYQRELLAHCYRMSGSVQEAEDLVQETFLRAWKASADFQGRSSVRTWLYRIATNVCLTNLEGRPRRPLPAGLGTPDAMAGDALEENHEIAWLEPVPDAAVVVAERDSIRLAFVAALQHLPARQRAVLILRDVLRWSAAEVAEALDTTSAAVNSALQRAHAQLAGRGLTEETVEPDLTPAQQQLLERYVDAFWRKDVDAIVSLLTSEAVWEMPPFTNWFVGPDNIGELIDKHCPGGWNDMPMLRTSANGQPAFGLYMRMADGGFTPFQLQVLELDGSRVAHVHAFFDTALFAKFGLPDRLDDDYRPGDHPMSLVPTSPAPSAPSPAGE
>NC_008699.1|WP_011758015.1|4862290_4863862_+|glycerol-3-phosphate-dehydrogenase/oxidase
MTGPTTTSRITPGLAGVPTEVDLVVIGLGITGAGVALDAASRGLSVLAVDAHDLAFGTSRWSSKMVHGGLRYLAKGQVGVAHESAVERGILMEVTAPHLTHPMPMLVPLSSSVTRLQTWLTRSGMWAGDLLRRGARTDAETLPKPRHLTVTEARSLVPALRPAGLRGAVLGWDGQLEDDARLVITIARTAASYGAQVRTHARVLEATGTSVRLRDETRSAEGDETTTVTARSVVNAAGVWAGGLVDGITLRPSRGTHLVLREETLPGLTVSVFCPVPGETNRFVMVLPQPDGTVYVGLTDEPVDGEIPDVPEASETEVGFLLDVVSAAFSHQLHRTDVVGTFAGLRPLLDLGGDGDGARTADLSRRHAVLTSSTGVITVVGGKLTTYRRMAEDAVDAAVAQAGLAASPCRTRELPLLGAAPRAELASLELPSRLVRRYGTDAALVLESAREVSGLADEELLAAVAPHVPVTLAELLFGVTHEGAADVDDLLDRRTRVGLVPADRELAVPAARRALEIAAPAVR
>NC_008699.1|WP_011758014.1|4861691_4862294_+|TetR/AcrR-family-transcriptional-regulator
MTSLRHNAPDRAEPRDGYLDAARACILDVGWRRTTLTEVARRAGVSRMTIYRTWADMPRLLADLMTREWGSVVADSLADEDPAAPTVDRLVGDIVQTVQRLRENELFVRIVELDPELILPYLFSRRGRSQDSILERTVAALRDAQAEGAARAGDPVAMARAMLLAAHGFVLSAHTMVDDDVSVEDLDAELVLALTRGLRP
>NC_008699.1|WP_011758013.1|4860096_4861653_-|FAD-binding-oxidoreductase
MHPSRWGDPTRARALPDEARGLVEMVFGVDDRPTVAHPALAPSALAPDLVAGLEEVVGVGHVLIDDATRRLRTRGKSTPDLLRARAGDLADAPDAVVRPGSHDEVAAVLAFAVEHHLAVVPFGGGTSVTGGLVARREGFAAVLSLDLVRMKRLLAVDHVSMTATLEPGLRGPEAEALLAAEGMTIGHFPQSFEYASLGGFAATRSSGQSSAGFGRFDALVVGLTVATPQGRIVLGTAPANAAGPDLRQLFLGSEGTLGVITSLTLRVRPVPAVQVYEAWRWPSFADGATAMRTLAQAGLLPTVLRLSDESESAINLADPAAIGGESAGGCLMVVGFEGEPAAVEAKRSAVTAVFEGLGGTGVGTGPGEKWAHGRYDAPYLRDSLLDAGVLVETLETATFWSNLDRLYTGVKTALETSLGQPSLVLCHISHVYETGASLYFTVAAKETDDPLGQWRVAKAAASDAMLAAGATITHHHAVGTDHLPWFEREIGPVGVSILRAVKADLDPTGVLNPGVLIP
>NC_008699.1|WP_041546952.1|4873045_4874941_-|penicillin-binding-protein
MRPSRRLPLATLALLLVGSALVGCDAAEKVTGPDPDEAAAALAEALVSGDFGAVAFTEGAAADVGAEYAKVVEGMGEVTPAVTATGTDESDAGAATATLSWTWSLAGEEWSYTTQAPLTEAADEWQVTWSRKVVEPSLGPGTVLDVTPIGGGRGPVLGAGGVALVTDRPVVRFGIDRSQVPAARAADAARRLARLVGVDPAPYAKQVEAAGEQAYVEAIVFRKDDVPLEVARGYQAIPGALAVPDDIPLAPTRDFAAPLLGTVGAVTAEMIEKEPDKYRVGDQAGLSGLQARYDDQLQGTDGVVVDAVASDGRERQLFRVDAKQGEPLELTLDERLQLAAERALAGVGPASALVALRTSTGAILAAANGPGNDGYNLATYGQLAPGSTFKSVSSLALLRAGLTPQSVVPCTPSIVVDGKRFENYDDYPSGALGDIALRTAIANSCNTAVISQRDKLGAGDLAAAAASLGLGIDHDLGFPAYFGSVEPPASETEAAADLIGQGRVLASPMAMATVIASVQAGHTVVPRLVESVDVSVPDRAKPLSGSEAAALRSMLRAVVTSGSGAGLLDVPGPPVIAKTGTAEFERGGKLLTHAWMIAAQGDLAVAVFVDLGSSGSGTAGPILEAFLRAAR
>NC_008699.1|WP_011758024.1|4875021_4876791_-|DEAD/DEAH-box-helicase
MSSDEQDDTTTPEVTFADLGLSDQVLKALADVGYEKPSAIQAATIPPLLAGRDVVGLAQTGTGKTAAFALPILSRLDLTQTTPQALVLAPTRELALQVCEAFERYAAHVKGVHVLPVYGGQGYGVQLSALRRGVHVVVGTPGRIMDHLEKGTLDLSELRFLVLDEADEMLNMGFAEDVETILADTPDDKNVALFSATMPAQIRRISKKYLDDPAEITVKGKTATASNITQRYLTVSYPQKVDALTRILEVENFEGMIVFVRTKNETETLAEKLRARGLSAMAINGDVAQAQRERTVNQLKSGKLDILVATDVAARGLDVERISHVVNYDIPTDTESYVHRIGRTGRAGRSGDAISFVTPRERYLLKHIEKATRQPLTQMQLPTVEDVNSTRLSRFDDAITEALSQTQRIDAFRDIVAHYVREHDVPEADVAAALAVVAQGETPLLLDPADRANELRAPREERAGQGTRRDRHDHGGPGGHGGPPRERRPRGRSDVPMATYRIAVGKRHKVEPRQIVGAIANEGGLSRQDFGHIDIRGDHSLVELPADLPAGAWDSLRSTRISGKLIELTRDGGGPAADTRHKKPRHKTR
>NC_008699.1|WP_011758025.1|4876867_4878700_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYVGAQQAAPILVEGLTRLEHRGYDSAGLAVLAGSGIKVAKRAGRVRDLADSLPKRFAGKVGIGHTRWATHGPANDVNAHPHSDAKGLVSVVHNGIIDNAAALRHRLADEGVDLVSDTDTEVLAHLVARSSADTLEGKVSQALAAIEGTYGIAVLHVDFPDRVVVARNGSPLIVGVGEREMFVASDLAAIVRHTTTVAHLDDGELATVTATGFTTYRQDLTATAKSATVLDVDPSSYDAGEHDSFMRKEMFEQPSAAERVLRGRLDERFGTAHLGGLNLDPRENRAIRRVKILGCGSAYYVGQMGAELVEELARIPADAEAASEFRYRNPIIEPDTLYVAVSQSGETIDTLLAVQEIRRKGGRVVGLVNVVGSAIARECDGGIYLHAGPEVAVASTKALTNMFLGFALLALQLGRVRDLSIADGRRLIAGLARLPGQIEEVLAQEGALAELAGRLAEAESLFFVGRVRGYPVAREGAQKFKEISYRHAEAYQTSELKHGPLALICETVPTVAIVPADELTDRNVGALHEIAARRGPLVVVTHDDVDLGDLADRPEVQRVVVPRNERELDPILLTVPLQLLAYHAALRLGHDIDKPRNLAKSVTVE
>NC_008699.1|WP_011758026.1|4878810_4879098_-|hypothetical-protein
MSGSTASPRSPDPELVGRIAASTGLSVGEAARVVEDVVAFHAETVAHYVQRRHAHLKTYGAKNDEIFALIAEELAHRVVAAPALTARQLRRLVYG
>NC_008699.1|WP_158305699.1|4879349_4879487_+|hypothetical-protein
MTNTTMTNSLVQTWVPVTDADGRTHLEARWTPAHAGAPVQAPHAA
>NC_008699.1|WP_011758028.1|4879667_4880258_+|YceI-family-protein
MSFFNRSSAEAFDAPTAAVEDISGDYTIDPTHTRIGFSTRHAMVTTVRGQFSEFNGTAHVDTANPENSRVELVIQTASIDTGVADRDAHLRSADFFDADQNKEITFVSTKVERGGDDWVITGDLTIKGVTKPVTVAFEPTGSARDPFGNLRIGFEGGSAINRKDWGLTWNAALETGGVLVSEKVKLEFDVSAIRNA
>NC_008699.1|WP_011758029.1|4880363_4881290_+|GNAT-family-N-acetyltransferase
MSPVPAPLELPADLSARPLVMSDARAVFEVMAAQEAHDTGEVAIEEADILGDWGRPSYDVSAGTVGVLDGERLVAYAELMGADRGDAAVHPDYRGRGIGTALAGWMQAKARAAGSEVIGMPVPRGSAGDRLLSALGYHVRWESWALRLPADAQIPPRDLPSGYTLREATPADHEACWTVIEDAFLEWSERDRMPLADWLATVVGRPGFEPWNLRVVTDPTGEVVGATQVFLSGEERAREGYVNKVATRRDQRGRGIAQAMLVDAFATARAHGAVGAGLDTDSRTGALSLYEKVGMVVSSTWVNRAIRV
>NC_008699.1|WP_049774497.1|4881302_4882571_-|acyl-CoA-dehydrogenase-family-protein
MARSRAHDPARVGNVPRVTPSFELDQDHLDLRTWVHDFAEEVVRPAAAEWDEREEFPWPVVEEAAKVGLYSVDFIVTQALDETGLGFPITMEELFWGDAGIGLSIVGTSLAAAGVRANGTDEQVAEWIPAMYGAPGDLKLGAFCSSEPDAGSDVGAMRTRATYDEAGDEWVLNGTKTWATNGGIADVHVVTAVVDPELRTRGQASFVVPPGTKGLSQGQKFHKHGIRASHTAEVVLDQVRVPGRCLLGGKEKLDARLARAREGARSAGSSNASMATFERTRPAVGAQAIGIARAAYEVALDYAKTREQFGRAIIENQAIAFTLADMATSIEASRLLVWRAAWMARQGKRFEQAEGSMSKLFAGETAVRVTGQAMQILGGNGFTREYPVERMARDAKIYTIFEGTSEIQRLVIARSISGAPIR
>NC_008699.1|WP_011758031.1|4882599_4884243_-|sodium:solute-symporter
MIADVNGVVLGVFVFLFLLVTVLGFAAARWRRAQSLDSLDEWGLGGRGFGTFIAWFLIGGDIYTAYTFIAVPATLYAGSAVGFFAVPYTIVVYPLIFVFLPRLWSVSHRHGYVTPADFVQGRYDSRPLALAVALTGILATMPYIALQLVGMQVVLEVMGLGTDSDNWLVKDFPLLLAFVVLAAYTYSSGLRAPALIAFVKDTLIYLVIIVAVVYLPSQLGGWEHIFSTVNDSFSSFNADNADAIAAGDAAPKGTMPPGPAQWAYASLALGSALALFMYPHSVTGVLSTRSRSVIRRNAALLPAYSFLLGLLALLGFVAIAAGVKVENPQQSVPQLFENEFSPWFAGVAFAAIVIGALVPAAIMSIAAANLWTRNIYKAFINRDATHAQEAKQSKVASLLVKFGALVFVLALSNSFAINLQLLGGVWILQTLPAIVIGLYTRWMHRWALFAGWAVGMAWGTWLAYGVSSPVQEHFGGPLVNFPGTETKFYIALIAFLANLLVAIVLTVVFRALDVAEGVDQTRAQDYHADVGDPGVESELEPHESVRA
>NC_008699.1|WP_011758032.1|4884239_4884551_-|DUF3311-domain-containing-protein
MSDVPRRPADRRSVPRGRWLIVAALLAPAVVLPLWVPLYDREDPSFLGFPFYYWFQFLLIVGAVTLTVPAYLVATGADRAHRLAHGLPPEPDGTAASRDGEPR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_008699_1	1.1\|156249\|39\|NC_008699\|CRISPRCasFinder	156249-156287	39	NC_008699.1	4669432-4669470	0	1.0
NC_008699_6	6.1\|297469\|38\|NC_008699\|CRISPRCasFinder	297469-297506	38	NC_008699.1	3858356-3858393	0	1.0
NC_008699_7	7.1\|361199\|39\|NC_008699\|CRISPRCasFinder	361199-361237	39	NC_008699.1	4669432-4669470	0	1.0
NC_008699_9	9.1\|456006\|39\|NC_008699\|CRISPRCasFinder	456006-456044	39	NC_008699.1	4669432-4669470	0	1.0
NC_008699_12	12.1\|546970\|38\|NC_008699\|CRISPRCasFinder	546970-547007	38	NC_008699.1	1198832-1198869	0	1.0
NC_008699_12	12.1\|546970\|38\|NC_008699\|CRISPRCasFinder	546970-547007	38	NC_008699.1	4753983-4754020	0	1.0
NC_008699_14	14.1\|1235777\|39\|NC_008699\|CRISPRCasFinder	1235777-1235815	39	NC_008699.1	4669432-4669470	0	1.0
NC_008699_16	16.1\|1306939\|34\|NC_008699\|CRISPRCasFinder	1306939-1306972	34	NC_008699.1	504072-504105	0	1.0
NC_008699_16	16.1\|1306939\|34\|NC_008699\|CRISPRCasFinder	1306939-1306972	34	NC_008699.1	2130493-2130526	0	1.0
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	1129652-1129689	0	1.0
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	1559068-1559105	0	1.0
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	4669432-4669469	0	1.0
NC_008699_19	19.1\|1892446\|39\|NC_008699\|CRISPRCasFinder	1892446-1892484	39	NC_008699.1	4669432-4669470	0	1.0
NC_008699_20	20.1\|2015590\|37\|NC_008699\|CRISPRCasFinder	2015590-2015626	37	NC_008699.1	1129652-1129688	0	1.0
NC_008699_20	20.1\|2015590\|37\|NC_008699\|CRISPRCasFinder	2015590-2015626	37	NC_008699.1	1559068-1559104	0	1.0
NC_008699_20	20.1\|2015590\|37\|NC_008699\|CRISPRCasFinder	2015590-2015626	37	NC_008699.1	4669432-4669468	0	1.0
NC_008699_23	23.1\|2576492\|39\|NC_008699\|CRISPRCasFinder	2576492-2576530	39	NC_008699.1	4669432-4669470	0	1.0
NC_008699_28	28.1\|4117185\|39\|NC_008699\|CRISPRCasFinder	4117185-4117223	39	NC_008699.1	4669432-4669470	0	1.0
NC_008699_31	31.1\|4745739\|39\|NC_008699\|CRISPRCasFinder	4745739-4745777	39	NC_008699.1	4669432-4669470	0	1.0
NC_008699_34	34.1\|4872976\|39\|NC_008699\|CRISPRCasFinder	4872976-4873014	39	NC_008699.1	4669432-4669470	0	1.0
NC_008699_1	1.1\|156249\|39\|NC_008699\|CRISPRCasFinder	156249-156287	39	NC_008699.1	4776326-4776364	1	0.974
NC_008699_3	3.1\|238696\|38\|NC_008699\|CRISPRCasFinder	238696-238733	38	NC_008699.1	4776326-4776363	1	0.974
NC_008699_7	7.1\|361199\|39\|NC_008699\|CRISPRCasFinder	361199-361237	39	NC_008699.1	4776326-4776364	1	0.974
NC_008699_9	9.1\|456006\|39\|NC_008699\|CRISPRCasFinder	456006-456044	39	NC_008699.1	4776326-4776364	1	0.974
NC_008699_14	14.1\|1235777\|39\|NC_008699\|CRISPRCasFinder	1235777-1235815	39	NC_008699.1	4776326-4776364	1	0.974
NC_008699_15	15.1\|1283038\|39\|NC_008699\|CRISPRCasFinder	1283038-1283076	39	NC_008699.1	504071-504109	1	0.974
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	314222-314259	1	0.974
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	4776326-4776363	1	0.974
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	469336-469373	1	0.974
NC_008699_18	18.1\|1580904\|38\|NC_008699\|CRISPRCasFinder	1580904-1580941	38	NC_008699.1	1129652-1129689	1	0.974
NC_008699_18	18.1\|1580904\|38\|NC_008699\|CRISPRCasFinder	1580904-1580941	38	NC_008699.1	1559068-1559105	1	0.974
NC_008699_18	18.1\|1580904\|38\|NC_008699\|CRISPRCasFinder	1580904-1580941	38	NC_008699.1	4669432-4669469	1	0.974
NC_008699_19	19.1\|1892446\|39\|NC_008699\|CRISPRCasFinder	1892446-1892484	39	NC_008699.1	4776326-4776364	1	0.974
NC_008699_20	20.1\|2015590\|37\|NC_008699\|CRISPRCasFinder	2015590-2015626	37	NC_008699.1	469337-469373	1	0.973
NC_008699_20	20.1\|2015590\|37\|NC_008699\|CRISPRCasFinder	2015590-2015626	37	NC_008699.1	4776326-4776362	1	0.973
NC_008699_21	21.1\|2155147\|39\|NC_008699\|CRISPRCasFinder	2155147-2155185	39	NC_008699.1	1129651-1129689	1	0.974
NC_008699_21	21.1\|2155147\|39\|NC_008699\|CRISPRCasFinder	2155147-2155185	39	NC_008699.1	1559067-1559105	1	0.974
NC_008699_21	21.1\|2155147\|39\|NC_008699\|CRISPRCasFinder	2155147-2155185	39	NC_008699.1	4669431-4669469	1	0.974
NC_008699_23	23.1\|2576492\|39\|NC_008699\|CRISPRCasFinder	2576492-2576530	39	NC_008699.1	4776326-4776364	1	0.974
NC_008699_25	25.1\|3379169\|39\|NC_008699\|CRISPRCasFinder	3379169-3379207	39	NC_008699.1	4669432-4669470	1	0.974
NC_008699_28	28.1\|4117185\|39\|NC_008699\|CRISPRCasFinder	4117185-4117223	39	NC_008699.1	4776326-4776364	1	0.974
NC_008699_31	31.1\|4745739\|39\|NC_008699\|CRISPRCasFinder	4745739-4745777	39	NC_008699.1	4776326-4776364	1	0.974
NC_008699_33	33.1\|4848594\|38\|NC_008699\|CRISPRCasFinder	4848594-4848631	38	NC_008699.1	1129652-1129689	1	0.974
NC_008699_33	33.1\|4848594\|38\|NC_008699\|CRISPRCasFinder	4848594-4848631	38	NC_008699.1	1559068-1559105	1	0.974
NC_008699_33	33.1\|4848594\|38\|NC_008699\|CRISPRCasFinder	4848594-4848631	38	NC_008699.1	4669432-4669469	1	0.974
NC_008699_34	34.1\|4872976\|39\|NC_008699\|CRISPRCasFinder	4872976-4873014	39	NC_008699.1	4776326-4776364	1	0.974
NC_008699_1	1.1\|156249\|39\|NC_008699\|CRISPRCasFinder	156249-156287	39	NC_008699.1	504071-504109	2	0.949
NC_008699_1	1.1\|156249\|39\|NC_008699\|CRISPRCasFinder	156249-156287	39	NC_008699.1	1198831-1198869	2	0.949
NC_008699_1	1.1\|156249\|39\|NC_008699\|CRISPRCasFinder	156249-156287	39	NC_008699.1	4736280-4736318	2	0.949
NC_008699_3	3.1\|238696\|38\|NC_008699\|CRISPRCasFinder	238696-238733	38	NC_008699.1	1129652-1129689	2	0.947
NC_008699_3	3.1\|238696\|38\|NC_008699\|CRISPRCasFinder	238696-238733	38	NC_008699.1	1559068-1559105	2	0.947
NC_008699_3	3.1\|238696\|38\|NC_008699\|CRISPRCasFinder	238696-238733	38	NC_008699.1	4669432-4669469	2	0.947
NC_008699_6	6.1\|297469\|38\|NC_008699\|CRISPRCasFinder	297469-297506	38	NC_008699.1	1129652-1129689	2	0.947
NC_008699_6	6.1\|297469\|38\|NC_008699\|CRISPRCasFinder	297469-297506	38	NC_008699.1	1559068-1559105	2	0.947
NC_008699_6	6.1\|297469\|38\|NC_008699\|CRISPRCasFinder	297469-297506	38	NC_008699.1	1768125-1768162	2	0.947
NC_008699_6	6.1\|297469\|38\|NC_008699\|CRISPRCasFinder	297469-297506	38	NC_008699.1	4669432-4669469	2	0.947
NC_008699_7	7.1\|361199\|39\|NC_008699\|CRISPRCasFinder	361199-361237	39	NC_008699.1	504071-504109	2	0.949
NC_008699_7	7.1\|361199\|39\|NC_008699\|CRISPRCasFinder	361199-361237	39	NC_008699.1	1198831-1198869	2	0.949
NC_008699_7	7.1\|361199\|39\|NC_008699\|CRISPRCasFinder	361199-361237	39	NC_008699.1	4736280-4736318	2	0.949
NC_008699_9	9.1\|456006\|39\|NC_008699\|CRISPRCasFinder	456006-456044	39	NC_008699.1	504071-504109	2	0.949
NC_008699_9	9.1\|456006\|39\|NC_008699\|CRISPRCasFinder	456006-456044	39	NC_008699.1	1198831-1198869	2	0.949
NC_008699_9	9.1\|456006\|39\|NC_008699\|CRISPRCasFinder	456006-456044	39	NC_008699.1	4736280-4736318	2	0.949
NC_008699_12	12.1\|546970\|38\|NC_008699\|CRISPRCasFinder	546970-547007	38	NC_008699.1	1129652-1129689	2	0.947
NC_008699_12	12.1\|546970\|38\|NC_008699\|CRISPRCasFinder	546970-547007	38	NC_008699.1	1559068-1559105	2	0.947
NC_008699_12	12.1\|546970\|38\|NC_008699\|CRISPRCasFinder	546970-547007	38	NC_008699.1	4669432-4669469	2	0.947
NC_008699_14	14.1\|1235777\|39\|NC_008699\|CRISPRCasFinder	1235777-1235815	39	NC_008699.1	504071-504109	2	0.949
NC_008699_14	14.1\|1235777\|39\|NC_008699\|CRISPRCasFinder	1235777-1235815	39	NC_008699.1	1198831-1198869	2	0.949
NC_008699_14	14.1\|1235777\|39\|NC_008699\|CRISPRCasFinder	1235777-1235815	39	NC_008699.1	4736280-4736318	2	0.949
NC_008699_16	16.1\|1306939\|34\|NC_008699\|CRISPRCasFinder	1306939-1306972	34	NC_008699.1	1129656-1129689	2	0.941
NC_008699_16	16.1\|1306939\|34\|NC_008699\|CRISPRCasFinder	1306939-1306972	34	NC_008699.1	1559072-1559105	2	0.941
NC_008699_16	16.1\|1306939\|34\|NC_008699\|CRISPRCasFinder	1306939-1306972	34	NC_008699.1	3397176-3397209	2	0.941
NC_008699_16	16.1\|1306939\|34\|NC_008699\|CRISPRCasFinder	1306939-1306972	34	NC_008699.1	4669436-4669469	2	0.941
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	2130489-2130526	2	0.947
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	4736280-4736317	2	0.947
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	4943217-4943254	2	0.947
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	504072-504109	2	0.947
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	1198832-1198869	2	0.947
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	3858356-3858393	2	0.947
NC_008699_17	17.1\|1574675\|38\|NC_008699\|CRISPRCasFinder	1574675-1574712	38	NC_008699.1	4753983-4754020	2	0.947
NC_008699_18	18.1\|1580904\|38\|NC_008699\|CRISPRCasFinder	1580904-1580941	38	NC_008699.1	314222-314259	2	0.947
NC_008699_18	18.1\|1580904\|38\|NC_008699\|CRISPRCasFinder	1580904-1580941	38	NC_008699.1	469336-469373	2	0.947
NC_008699_18	18.1\|1580904\|38\|NC_008699\|CRISPRCasFinder	1580904-1580941	38	NC_008699.1	4776326-4776363	2	0.947
NC_008699_19	19.1\|1892446\|39\|NC_008699\|CRISPRCasFinder	1892446-1892484	39	NC_008699.1	504071-504109	2	0.949
NC_008699_19	19.1\|1892446\|39\|NC_008699\|CRISPRCasFinder	1892446-1892484	39	NC_008699.1	1198831-1198869	2	0.949
NC_008699_19	19.1\|1892446\|39\|NC_008699\|CRISPRCasFinder	1892446-1892484	39	NC_008699.1	4736280-4736318	2	0.949
NC_008699_20	20.1\|2015590\|37\|NC_008699\|CRISPRCasFinder	2015590-2015626	37	NC_008699.1	504073-504109	2	0.946
NC_008699_20	20.1\|2015590\|37\|NC_008699\|CRISPRCasFinder	2015590-2015626	37	NC_008699.1	1198833-1198869	2	0.946
NC_008699_20	20.1\|2015590\|37\|NC_008699\|CRISPRCasFinder	2015590-2015626	37	NC_008699.1	3858357-3858393	2	0.946
NC_008699_20	20.1\|2015590\|37\|NC_008699\|CRISPRCasFinder	2015590-2015626	37	NC_008699.1	4753984-4754020	2	0.946
NC_008699_20	20.1\|2015590\|37\|NC_008699\|CRISPRCasFinder	2015590-2015626	37	NC_008699.1	2130489-2130525	2	0.946
NC_008699_20	20.1\|2015590\|37\|NC_008699\|CRISPRCasFinder	2015590-2015626	37	NC_008699.1	4736280-4736316	2	0.946
NC_008699_20	20.1\|2015590\|37\|NC_008699\|CRISPRCasFinder	2015590-2015626	37	NC_008699.1	4943217-4943253	2	0.946
NC_008699_21	21.1\|2155147\|39\|NC_008699\|CRISPRCasFinder	2155147-2155185	39	NC_008699.1	469336-469374	2	0.949
NC_008699_21	21.1\|2155147\|39\|NC_008699\|CRISPRCasFinder	2155147-2155185	39	NC_008699.1	314221-314259	2	0.949
NC_008699_21	21.1\|2155147\|39\|NC_008699\|CRISPRCasFinder	2155147-2155185	39	NC_008699.1	4776325-4776363	2	0.949
NC_008699_23	23.1\|2576492\|39\|NC_008699\|CRISPRCasFinder	2576492-2576530	39	NC_008699.1	504071-504109	2	0.949
NC_008699_23	23.1\|2576492\|39\|NC_008699\|CRISPRCasFinder	2576492-2576530	39	NC_008699.1	1198831-1198869	2	0.949
NC_008699_23	23.1\|2576492\|39\|NC_008699\|CRISPRCasFinder	2576492-2576530	39	NC_008699.1	4736280-4736318	2	0.949
NC_008699_25	25.1\|3379169\|39\|NC_008699\|CRISPRCasFinder	3379169-3379207	39	NC_008699.1	4776326-4776364	2	0.949
NC_008699_26	26.1\|3655194\|38\|NC_008699\|CRISPRCasFinder	3655194-3655231	38	NC_008699.1	504072-504109	2	0.947
NC_008699_26	26.1\|3655194\|38\|NC_008699\|CRISPRCasFinder	3655194-3655231	38	NC_008699.1	1129652-1129689	2	0.947
NC_008699_26	26.1\|3655194\|38\|NC_008699\|CRISPRCasFinder	3655194-3655231	38	NC_008699.1	1559068-1559105	2	0.947
NC_008699_26	26.1\|3655194\|38\|NC_008699\|CRISPRCasFinder	3655194-3655231	38	NC_008699.1	2130489-2130526	2	0.947
NC_008699_26	26.1\|3655194\|38\|NC_008699\|CRISPRCasFinder	3655194-3655231	38	NC_008699.1	4669432-4669469	2	0.947
NC_008699_28	28.1\|4117185\|39\|NC_008699\|CRISPRCasFinder	4117185-4117223	39	NC_008699.1	504071-504109	2	0.949
NC_008699_28	28.1\|4117185\|39\|NC_008699\|CRISPRCasFinder	4117185-4117223	39	NC_008699.1	1198831-1198869	2	0.949
NC_008699_28	28.1\|4117185\|39\|NC_008699\|CRISPRCasFinder	4117185-4117223	39	NC_008699.1	4736280-4736318	2	0.949
NC_008699_30	30.1\|4474588\|38\|NC_008699\|CRISPRCasFinder	4474588-4474625	38	NC_008699.1	4283117-4283154	2	0.947
NC_008699_31	31.1\|4745739\|39\|NC_008699\|CRISPRCasFinder	4745739-4745777	39	NC_008699.1	504071-504109	2	0.949
NC_008699_31	31.1\|4745739\|39\|NC_008699\|CRISPRCasFinder	4745739-4745777	39	NC_008699.1	1198831-1198869	2	0.949
NC_008699_31	31.1\|4745739\|39\|NC_008699\|CRISPRCasFinder	4745739-4745777	39	NC_008699.1	4736280-4736318	2	0.949
NC_008699_33	33.1\|4848594\|38\|NC_008699\|CRISPRCasFinder	4848594-4848631	38	NC_008699.1	314222-314259	2	0.947
NC_008699_33	33.1\|4848594\|38\|NC_008699\|CRISPRCasFinder	4848594-4848631	38	NC_008699.1	469336-469373	2	0.947
NC_008699_33	33.1\|4848594\|38\|NC_008699\|CRISPRCasFinder	4848594-4848631	38	NC_008699.1	4776326-4776363	2	0.947
NC_008699_34	34.1\|4872976\|39\|NC_008699\|CRISPRCasFinder	4872976-4873014	39	NC_008699.1	504071-504109	2	0.949
NC_008699_34	34.1\|4872976\|39\|NC_008699\|CRISPRCasFinder	4872976-4873014	39	NC_008699.1	1198831-1198869	2	0.949
NC_008699_34	34.1\|4872976\|39\|NC_008699\|CRISPRCasFinder	4872976-4873014	39	NC_008699.1	4736280-4736318	2	0.949

1. spacer 1.1|156249|39|NC_008699|CRISPRCasFinder matches to position: 4669432-4669470, mismatch: 0, identity: 1.0

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaaca	Protospacer
***************************************

2. spacer 6.1|297469|38|NC_008699|CRISPRCasFinder matches to position: 3858356-3858393, mismatch: 0, identity: 1.0

gaactgttgggccgaaacttcgggccaacagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccaacagttccaac	Protospacer
**************************************

3. spacer 7.1|361199|39|NC_008699|CRISPRCasFinder matches to position: 4669432-4669470, mismatch: 0, identity: 1.0

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaagtttcggcccaacagttc	Protospacer
***************************************

4. spacer 9.1|456006|39|NC_008699|CRISPRCasFinder matches to position: 4669432-4669470, mismatch: 0, identity: 1.0

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaagtttcggcccaacagttc	Protospacer
***************************************

5. spacer 12.1|546970|38|NC_008699|CRISPRCasFinder matches to position: 1198832-1198869, mismatch: 0, identity: 1.0

gaactgttgacccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgacccgaaacttcgggccagaagttccaac	Protospacer
**************************************

6. spacer 12.1|546970|38|NC_008699|CRISPRCasFinder matches to position: 4753983-4754020, mismatch: 0, identity: 1.0

gaactgttgacccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgacccgaaacttcgggccagaagttccaac	Protospacer
**************************************

7. spacer 14.1|1235777|39|NC_008699|CRISPRCasFinder matches to position: 4669432-4669470, mismatch: 0, identity: 1.0

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaagtttcggcccaacagttc	Protospacer
***************************************

8. spacer 16.1|1306939|34|NC_008699|CRISPRCasFinder matches to position: 504072-504105, mismatch: 0, identity: 1.0

tgttgggccgaagtttcgggccagaagttccaac	CRISPR spacer
tgttgggccgaagtttcgggccagaagttccaac	Protospacer
**********************************

9. spacer 16.1|1306939|34|NC_008699|CRISPRCasFinder matches to position: 2130493-2130526, mismatch: 0, identity: 1.0

tgttgggccgaagtttcgggccagaagttccaac	CRISPR spacer
tgttgggccgaagtttcgggccagaagttccaac	Protospacer
**********************************

10. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 1129652-1129689, mismatch: 0, identity: 1.0

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
**************************************

11. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 1559068-1559105, mismatch: 0, identity: 1.0

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
**************************************

12. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 4669432-4669469, mismatch: 0, identity: 1.0

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
**************************************

13. spacer 19.1|1892446|39|NC_008699|CRISPRCasFinder matches to position: 4669432-4669470, mismatch: 0, identity: 1.0

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaaca	Protospacer
***************************************

14. spacer 20.1|2015590|37|NC_008699|CRISPRCasFinder matches to position: 1129652-1129688, mismatch: 0, identity: 1.0

gaactgttgggccgaaacttcgggccagaagttccaa	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaa	Protospacer
*************************************

15. spacer 20.1|2015590|37|NC_008699|CRISPRCasFinder matches to position: 1559068-1559104, mismatch: 0, identity: 1.0

gaactgttgggccgaaacttcgggccagaagttccaa	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaa	Protospacer
*************************************

16. spacer 20.1|2015590|37|NC_008699|CRISPRCasFinder matches to position: 4669432-4669468, mismatch: 0, identity: 1.0

gaactgttgggccgaaacttcgggccagaagttccaa	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaa	Protospacer
*************************************

17. spacer 23.1|2576492|39|NC_008699|CRISPRCasFinder matches to position: 4669432-4669470, mismatch: 0, identity: 1.0

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaaca	Protospacer
***************************************

18. spacer 28.1|4117185|39|NC_008699|CRISPRCasFinder matches to position: 4669432-4669470, mismatch: 0, identity: 1.0

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaaca	Protospacer
***************************************

19. spacer 31.1|4745739|39|NC_008699|CRISPRCasFinder matches to position: 4669432-4669470, mismatch: 0, identity: 1.0

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaagtttcggcccaacagttc	Protospacer
***************************************

20. spacer 34.1|4872976|39|NC_008699|CRISPRCasFinder matches to position: 4669432-4669470, mismatch: 0, identity: 1.0

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaaca	Protospacer
***************************************

21. spacer 1.1|156249|39|NC_008699|CRISPRCasFinder matches to position: 4776326-4776364, mismatch: 1, identity: 0.974

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaaccgttgggccgaaacttcgggccagaagttccaaca	Protospacer
****.**********************************

22. spacer 3.1|238696|38|NC_008699|CRISPRCasFinder matches to position: 4776326-4776363, mismatch: 1, identity: 0.974

gaaccgttgggccgaaacttcggggcagaagttccaac	CRISPR spacer
gaaccgttgggccgaaacttcgggccagaagttccaac	Protospacer
************************ *************

23. spacer 7.1|361199|39|NC_008699|CRISPRCasFinder matches to position: 4776326-4776364, mismatch: 1, identity: 0.974

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaagtttcggcccaacggttc	Protospacer
**********************************.****

24. spacer 9.1|456006|39|NC_008699|CRISPRCasFinder matches to position: 4776326-4776364, mismatch: 1, identity: 0.974

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaagtttcggcccaacggttc	Protospacer
**********************************.****

25. spacer 14.1|1235777|39|NC_008699|CRISPRCasFinder matches to position: 4776326-4776364, mismatch: 1, identity: 0.974

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaagtttcggcccaacggttc	Protospacer
**********************************.****

26. spacer 15.1|1283038|39|NC_008699|CRISPRCasFinder matches to position: 504071-504109, mismatch: 1, identity: 0.974

gaactgttgggccgaagtttcgggcaagaagttccaaca	CRISPR spacer
gaactgttgggccgaagtttcgggccagaagttccaaca	Protospacer
************************* *************

27. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 314222-314259, mismatch: 1, identity: 0.974

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccgac	Protospacer
***********************************.**

28. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 4776326-4776363, mismatch: 1, identity: 0.974

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaaccgttgggccgaaacttcgggccagaagttccaac	Protospacer
****.*********************************

29. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 469336-469373, mismatch: 1, identity: 0.974

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttggggcgaaacttcgggccagaagttccaac	Protospacer
*********** **************************

30. spacer 18.1|1580904|38|NC_008699|CRISPRCasFinder matches to position: 1129652-1129689, mismatch: 1, identity: 0.974

gttggaacttctggcccgaagtttcggcccaacacttc	CRISPR spacer
gttggaacttctggcccgaagtttcggcccaacagttc	Protospacer
********************************** ***

31. spacer 18.1|1580904|38|NC_008699|CRISPRCasFinder matches to position: 1559068-1559105, mismatch: 1, identity: 0.974

gttggaacttctggcccgaagtttcggcccaacacttc	CRISPR spacer
gttggaacttctggcccgaagtttcggcccaacagttc	Protospacer
********************************** ***

32. spacer 18.1|1580904|38|NC_008699|CRISPRCasFinder matches to position: 4669432-4669469, mismatch: 1, identity: 0.974

gttggaacttctggcccgaagtttcggcccaacacttc	CRISPR spacer
gttggaacttctggcccgaagtttcggcccaacagttc	Protospacer
********************************** ***

33. spacer 19.1|1892446|39|NC_008699|CRISPRCasFinder matches to position: 4776326-4776364, mismatch: 1, identity: 0.974

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaaccgttgggccgaaacttcgggccagaagttccaaca	Protospacer
****.**********************************

34. spacer 20.1|2015590|37|NC_008699|CRISPRCasFinder matches to position: 469337-469373, mismatch: 1, identity: 0.973

gaactgttgggccgaaacttcgggccagaagttccaa	CRISPR spacer
gaactgttggggcgaaacttcgggccagaagttccaa	Protospacer
*********** *************************

35. spacer 20.1|2015590|37|NC_008699|CRISPRCasFinder matches to position: 4776326-4776362, mismatch: 1, identity: 0.973

gaactgttgggccgaaacttcgggccagaagttccaa	CRISPR spacer
gaaccgttgggccgaaacttcgggccagaagttccaa	Protospacer
****.********************************

36. spacer 21.1|2155147|39|NC_008699|CRISPRCasFinder matches to position: 1129651-1129689, mismatch: 1, identity: 0.974

ggaactgttgggccgaaacttcgggccagaggttccaac	CRISPR spacer
ggaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
******************************.********

37. spacer 21.1|2155147|39|NC_008699|CRISPRCasFinder matches to position: 1559067-1559105, mismatch: 1, identity: 0.974

ggaactgttgggccgaaacttcgggccagaggttccaac	CRISPR spacer
ggaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
******************************.********

38. spacer 21.1|2155147|39|NC_008699|CRISPRCasFinder matches to position: 4669431-4669469, mismatch: 1, identity: 0.974

ggaactgttgggccgaaacttcgggccagaggttccaac	CRISPR spacer
ggaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
******************************.********

39. spacer 23.1|2576492|39|NC_008699|CRISPRCasFinder matches to position: 4776326-4776364, mismatch: 1, identity: 0.974

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaaccgttgggccgaaacttcgggccagaagttccaaca	Protospacer
****.**********************************

40. spacer 25.1|3379169|39|NC_008699|CRISPRCasFinder matches to position: 4669432-4669470, mismatch: 1, identity: 0.974

gaactgttggggcgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaaca	Protospacer
*********** ***************************

41. spacer 28.1|4117185|39|NC_008699|CRISPRCasFinder matches to position: 4776326-4776364, mismatch: 1, identity: 0.974

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaaccgttgggccgaaacttcgggccagaagttccaaca	Protospacer
****.**********************************

42. spacer 31.1|4745739|39|NC_008699|CRISPRCasFinder matches to position: 4776326-4776364, mismatch: 1, identity: 0.974

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaagtttcggcccaacggttc	Protospacer
**********************************.****

43. spacer 33.1|4848594|38|NC_008699|CRISPRCasFinder matches to position: 1129652-1129689, mismatch: 1, identity: 0.974

gaactgttgggccgaaacttcggggcagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
************************ *************

44. spacer 33.1|4848594|38|NC_008699|CRISPRCasFinder matches to position: 1559068-1559105, mismatch: 1, identity: 0.974

gaactgttgggccgaaacttcggggcagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
************************ *************

45. spacer 33.1|4848594|38|NC_008699|CRISPRCasFinder matches to position: 4669432-4669469, mismatch: 1, identity: 0.974

gaactgttgggccgaaacttcggggcagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
************************ *************

46. spacer 34.1|4872976|39|NC_008699|CRISPRCasFinder matches to position: 4776326-4776364, mismatch: 1, identity: 0.974

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaaccgttgggccgaaacttcgggccagaagttccaaca	Protospacer
****.**********************************

47. spacer 1.1|156249|39|NC_008699|CRISPRCasFinder matches to position: 504071-504109, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaagtttcgggccagaagttccaaca	Protospacer
****************..*********************

48. spacer 1.1|156249|39|NC_008699|CRISPRCasFinder matches to position: 1198831-1198869, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgacccgaaacttcgggccagaagttccaaca	Protospacer
*********. ****************************

49. spacer 1.1|156249|39|NC_008699|CRISPRCasFinder matches to position: 4736280-4736318, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaaacttcagcccagaagttccaaca	Protospacer
*********************.* ***************

50. spacer 3.1|238696|38|NC_008699|CRISPRCasFinder matches to position: 1129652-1129689, mismatch: 2, identity: 0.947

gaaccgttgggccgaaacttcggggcagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
****.******************* *************

51. spacer 3.1|238696|38|NC_008699|CRISPRCasFinder matches to position: 1559068-1559105, mismatch: 2, identity: 0.947

gaaccgttgggccgaaacttcggggcagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
****.******************* *************

52. spacer 3.1|238696|38|NC_008699|CRISPRCasFinder matches to position: 4669432-4669469, mismatch: 2, identity: 0.947

gaaccgttgggccgaaacttcggggcagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
****.******************* *************

53. spacer 6.1|297469|38|NC_008699|CRISPRCasFinder matches to position: 1129652-1129689, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcgggccaacagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
***************************. *********

54. spacer 6.1|297469|38|NC_008699|CRISPRCasFinder matches to position: 1559068-1559105, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcgggccaacagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
***************************. *********

55. spacer 6.1|297469|38|NC_008699|CRISPRCasFinder matches to position: 1768125-1768162, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcgggccaacagttccaac	CRISPR spacer
gaactgttgccccgaaacttcgggccaacagttccaac	Protospacer
*********  ***************************

56. spacer 6.1|297469|38|NC_008699|CRISPRCasFinder matches to position: 4669432-4669469, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcgggccaacagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
***************************. *********

57. spacer 7.1|361199|39|NC_008699|CRISPRCasFinder matches to position: 504071-504109, mismatch: 2, identity: 0.949

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaaacttcggcccaacagttc	Protospacer
*********************..****************

58. spacer 7.1|361199|39|NC_008699|CRISPRCasFinder matches to position: 1198831-1198869, mismatch: 2, identity: 0.949

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaagtttcgggtcaacagttc	Protospacer
**************************** .*********

59. spacer 7.1|361199|39|NC_008699|CRISPRCasFinder matches to position: 4736280-4736318, mismatch: 2, identity: 0.949

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctgggctgaagtttcggcccaacagttc	Protospacer
*************** *.*********************

60. spacer 9.1|456006|39|NC_008699|CRISPRCasFinder matches to position: 504071-504109, mismatch: 2, identity: 0.949

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaaacttcggcccaacagttc	Protospacer
*********************..****************

61. spacer 9.1|456006|39|NC_008699|CRISPRCasFinder matches to position: 1198831-1198869, mismatch: 2, identity: 0.949

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaagtttcgggtcaacagttc	Protospacer
**************************** .*********

62. spacer 9.1|456006|39|NC_008699|CRISPRCasFinder matches to position: 4736280-4736318, mismatch: 2, identity: 0.949

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctgggctgaagtttcggcccaacagttc	Protospacer
*************** *.*********************

63. spacer 12.1|546970|38|NC_008699|CRISPRCasFinder matches to position: 1129652-1129689, mismatch: 2, identity: 0.947

gaactgttgacccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
*********. ***************************

64. spacer 12.1|546970|38|NC_008699|CRISPRCasFinder matches to position: 1559068-1559105, mismatch: 2, identity: 0.947

gaactgttgacccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
*********. ***************************

65. spacer 12.1|546970|38|NC_008699|CRISPRCasFinder matches to position: 4669432-4669469, mismatch: 2, identity: 0.947

gaactgttgacccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
*********. ***************************

66. spacer 14.1|1235777|39|NC_008699|CRISPRCasFinder matches to position: 504071-504109, mismatch: 2, identity: 0.949

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaaacttcggcccaacagttc	Protospacer
*********************..****************

67. spacer 14.1|1235777|39|NC_008699|CRISPRCasFinder matches to position: 1198831-1198869, mismatch: 2, identity: 0.949

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaagtttcgggtcaacagttc	Protospacer
**************************** .*********

68. spacer 14.1|1235777|39|NC_008699|CRISPRCasFinder matches to position: 4736280-4736318, mismatch: 2, identity: 0.949

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctgggctgaagtttcggcccaacagttc	Protospacer
*************** *.*********************

69. spacer 16.1|1306939|34|NC_008699|CRISPRCasFinder matches to position: 1129656-1129689, mismatch: 2, identity: 0.941

tgttgggccgaagtttcgggccagaagttccaac	CRISPR spacer
tgttgggccgaaacttcgggccagaagttccaac	Protospacer
************..********************

70. spacer 16.1|1306939|34|NC_008699|CRISPRCasFinder matches to position: 1559072-1559105, mismatch: 2, identity: 0.941

tgttgggccgaagtttcgggccagaagttccaac	CRISPR spacer
tgttgggccgaaacttcgggccagaagttccaac	Protospacer
************..********************

71. spacer 16.1|1306939|34|NC_008699|CRISPRCasFinder matches to position: 3397176-3397209, mismatch: 2, identity: 0.941

tgttgggccgaagtttcgggccagaagttccaac	CRISPR spacer
tgttcggccgaagtttcgggccagatgttccaac	Protospacer
**** ******************** ********

72. spacer 16.1|1306939|34|NC_008699|CRISPRCasFinder matches to position: 4669436-4669469, mismatch: 2, identity: 0.941

tgttgggccgaagtttcgggccagaagttccaac	CRISPR spacer
tgttgggccgaaacttcgggccagaagttccaac	Protospacer
************..********************

73. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 2130489-2130526, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaagtttcgggccagaagttccaac	Protospacer
****************..********************

74. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 4736280-4736317, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcagcccagaagttccaac	Protospacer
*********************.* **************

75. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 4943217-4943254, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagtggcaac	Protospacer
********************************  ****

76. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 504072-504109, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaagtttcgggccagaagttccaac	Protospacer
****************..********************

77. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 1198832-1198869, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgacccgaaacttcgggccagaagttccaac	Protospacer
*********. ***************************

78. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 3858356-3858393, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccaacagttccaac	Protospacer
***************************. *********

79. spacer 17.1|1574675|38|NC_008699|CRISPRCasFinder matches to position: 4753983-4754020, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcgggccagaagttccaac	CRISPR spacer
gaactgttgacccgaaacttcgggccagaagttccaac	Protospacer
*********. ***************************

80. spacer 18.1|1580904|38|NC_008699|CRISPRCasFinder matches to position: 314222-314259, mismatch: 2, identity: 0.947

gttggaacttctggcccgaagtttcggcccaacacttc	CRISPR spacer
gtcggaacttctggcccgaagtttcggcccaacagttc	Protospacer
**.******************************* ***

81. spacer 18.1|1580904|38|NC_008699|CRISPRCasFinder matches to position: 469336-469373, mismatch: 2, identity: 0.947

gttggaacttctggcccgaagtttcggcccaacacttc	CRISPR spacer
gttggaacttctggcccgaagtttcgccccaacagttc	Protospacer
************************** ******* ***

82. spacer 18.1|1580904|38|NC_008699|CRISPRCasFinder matches to position: 4776326-4776363, mismatch: 2, identity: 0.947

gttggaacttctggcccgaagtttcggcccaacacttc	CRISPR spacer
gttggaacttctggcccgaagtttcggcccaacggttc	Protospacer
*********************************. ***

83. spacer 19.1|1892446|39|NC_008699|CRISPRCasFinder matches to position: 504071-504109, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaagtttcgggccagaagttccaaca	Protospacer
****************..*********************

84. spacer 19.1|1892446|39|NC_008699|CRISPRCasFinder matches to position: 1198831-1198869, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgacccgaaacttcgggccagaagttccaaca	Protospacer
*********. ****************************

85. spacer 19.1|1892446|39|NC_008699|CRISPRCasFinder matches to position: 4736280-4736318, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaaacttcagcccagaagttccaaca	Protospacer
*********************.* ***************

86. spacer 20.1|2015590|37|NC_008699|CRISPRCasFinder matches to position: 504073-504109, mismatch: 2, identity: 0.946

gaactgttgggccgaaacttcgggccagaagttccaa	CRISPR spacer
gaactgttgggccgaagtttcgggccagaagttccaa	Protospacer
****************..*******************

87. spacer 20.1|2015590|37|NC_008699|CRISPRCasFinder matches to position: 1198833-1198869, mismatch: 2, identity: 0.946

gaactgttgggccgaaacttcgggccagaagttccaa	CRISPR spacer
gaactgttgacccgaaacttcgggccagaagttccaa	Protospacer
*********. **************************

88. spacer 20.1|2015590|37|NC_008699|CRISPRCasFinder matches to position: 3858357-3858393, mismatch: 2, identity: 0.946

gaactgttgggccgaaacttcgggccagaagttccaa	CRISPR spacer
gaactgttgggccgaaacttcgggccaacagttccaa	Protospacer
***************************. ********

89. spacer 20.1|2015590|37|NC_008699|CRISPRCasFinder matches to position: 4753984-4754020, mismatch: 2, identity: 0.946

gaactgttgggccgaaacttcgggccagaagttccaa	CRISPR spacer
gaactgttgacccgaaacttcgggccagaagttccaa	Protospacer
*********. **************************

90. spacer 20.1|2015590|37|NC_008699|CRISPRCasFinder matches to position: 2130489-2130525, mismatch: 2, identity: 0.946

gaactgttgggccgaaacttcgggccagaagttccaa	CRISPR spacer
gaactgttgggccgaagtttcgggccagaagttccaa	Protospacer
****************..*******************

91. spacer 20.1|2015590|37|NC_008699|CRISPRCasFinder matches to position: 4736280-4736316, mismatch: 2, identity: 0.946

gaactgttgggccgaaacttcgggccagaagttccaa	CRISPR spacer
gaactgttgggccgaaacttcagcccagaagttccaa	Protospacer
*********************.* *************

92. spacer 20.1|2015590|37|NC_008699|CRISPRCasFinder matches to position: 4943217-4943253, mismatch: 2, identity: 0.946

gaactgttgggccgaaacttcgggccagaagttccaa	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagtggcaa	Protospacer
********************************  ***

93. spacer 21.1|2155147|39|NC_008699|CRISPRCasFinder matches to position: 469336-469374, mismatch: 2, identity: 0.949

ggaactgttgggccgaaacttcgggccagaggttccaac	CRISPR spacer
ggaactgttggggcgaaacttcgggccagaagttccaac	Protospacer
************ *****************.********

94. spacer 21.1|2155147|39|NC_008699|CRISPRCasFinder matches to position: 314221-314259, mismatch: 2, identity: 0.949

ggaactgttgggccgaaacttcgggccagaggttccaac	CRISPR spacer
ggaactgttgggccgaaacttcgggccagaagttccgac	Protospacer
******************************.*****.**

95. spacer 21.1|2155147|39|NC_008699|CRISPRCasFinder matches to position: 4776325-4776363, mismatch: 2, identity: 0.949

ggaactgttgggccgaaacttcgggccagaggttccaac	CRISPR spacer
ggaaccgttgggccgaaacttcgggccagaagttccaac	Protospacer
*****.************************.********

96. spacer 23.1|2576492|39|NC_008699|CRISPRCasFinder matches to position: 504071-504109, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaagtttcgggccagaagttccaaca	Protospacer
****************..*********************

97. spacer 23.1|2576492|39|NC_008699|CRISPRCasFinder matches to position: 1198831-1198869, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgacccgaaacttcgggccagaagttccaaca	Protospacer
*********. ****************************

98. spacer 23.1|2576492|39|NC_008699|CRISPRCasFinder matches to position: 4736280-4736318, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaaacttcagcccagaagttccaaca	Protospacer
*********************.* ***************

99. spacer 25.1|3379169|39|NC_008699|CRISPRCasFinder matches to position: 4776326-4776364, mismatch: 2, identity: 0.949

gaactgttggggcgaaacttcgggccagaagttccaaca	CRISPR spacer
gaaccgttgggccgaaacttcgggccagaagttccaaca	Protospacer
****.****** ***************************

100. spacer 26.1|3655194|38|NC_008699|CRISPRCasFinder matches to position: 504072-504109, mismatch: 2, identity: 0.947

gaactgttgggccaaaatttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaagtttcgggccagaagttccaac	Protospacer
*************.**.*********************

101. spacer 26.1|3655194|38|NC_008699|CRISPRCasFinder matches to position: 1129652-1129689, mismatch: 2, identity: 0.947

gaactgttgggccaaaatttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
*************.***.********************

102. spacer 26.1|3655194|38|NC_008699|CRISPRCasFinder matches to position: 1559068-1559105, mismatch: 2, identity: 0.947

gaactgttgggccaaaatttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
*************.***.********************

103. spacer 26.1|3655194|38|NC_008699|CRISPRCasFinder matches to position: 2130489-2130526, mismatch: 2, identity: 0.947

gaactgttgggccaaaatttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaagtttcgggccagaagttccaac	Protospacer
*************.**.*********************

104. spacer 26.1|3655194|38|NC_008699|CRISPRCasFinder matches to position: 4669432-4669469, mismatch: 2, identity: 0.947

gaactgttgggccaaaatttcgggccagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccaac	Protospacer
*************.***.********************

105. spacer 28.1|4117185|39|NC_008699|CRISPRCasFinder matches to position: 504071-504109, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaagtttcgggccagaagttccaaca	Protospacer
****************..*********************

106. spacer 28.1|4117185|39|NC_008699|CRISPRCasFinder matches to position: 1198831-1198869, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgacccgaaacttcgggccagaagttccaaca	Protospacer
*********. ****************************

107. spacer 28.1|4117185|39|NC_008699|CRISPRCasFinder matches to position: 4736280-4736318, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaaacttcagcccagaagttccaaca	Protospacer
*********************.* ***************

108. spacer 30.1|4474588|38|NC_008699|CRISPRCasFinder matches to position: 4283117-4283154, mismatch: 2, identity: 0.947

ctggacgatgcagcttcatcgtccagggtcgagatctg	CRISPR spacer
ctggacgatgcagcttcatcgtccagggtcgagctttg	Protospacer
********************************* *.**

109. spacer 31.1|4745739|39|NC_008699|CRISPRCasFinder matches to position: 504071-504109, mismatch: 2, identity: 0.949

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaaacttcggcccaacagttc	Protospacer
*********************..****************

110. spacer 31.1|4745739|39|NC_008699|CRISPRCasFinder matches to position: 1198831-1198869, mismatch: 2, identity: 0.949

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctggcccgaagtttcgggtcaacagttc	Protospacer
**************************** .*********

111. spacer 31.1|4745739|39|NC_008699|CRISPRCasFinder matches to position: 4736280-4736318, mismatch: 2, identity: 0.949

tgttggaacttctggcccgaagtttcggcccaacagttc	CRISPR spacer
tgttggaacttctgggctgaagtttcggcccaacagttc	Protospacer
*************** *.*********************

112. spacer 33.1|4848594|38|NC_008699|CRISPRCasFinder matches to position: 314222-314259, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcggggcagaagttccaac	CRISPR spacer
gaactgttgggccgaaacttcgggccagaagttccgac	Protospacer
************************ **********.**

113. spacer 33.1|4848594|38|NC_008699|CRISPRCasFinder matches to position: 469336-469373, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcggggcagaagttccaac	CRISPR spacer
gaactgttggggcgaaacttcgggccagaagttccaac	Protospacer
*********** ************ *************

114. spacer 33.1|4848594|38|NC_008699|CRISPRCasFinder matches to position: 4776326-4776363, mismatch: 2, identity: 0.947

gaactgttgggccgaaacttcggggcagaagttccaac	CRISPR spacer
gaaccgttgggccgaaacttcgggccagaagttccaac	Protospacer
****.******************* *************

115. spacer 34.1|4872976|39|NC_008699|CRISPRCasFinder matches to position: 504071-504109, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaagtttcgggccagaagttccaaca	Protospacer
****************..*********************

116. spacer 34.1|4872976|39|NC_008699|CRISPRCasFinder matches to position: 1198831-1198869, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgacccgaaacttcgggccagaagttccaaca	Protospacer
*********. ****************************

117. spacer 34.1|4872976|39|NC_008699|CRISPRCasFinder matches to position: 4736280-4736318, mismatch: 2, identity: 0.949

gaactgttgggccgaaacttcgggccagaagttccaaca	CRISPR spacer
gaactgttgggccgaaacttcagcccagaagttccaaca	Protospacer
*********************.* ***************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	KM879463	Arthrobacter phage vB_ArtM-ArV1, complete genome	5184-5213	5	0.833
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	NZ_CP015231	Epibacterium mobile F1926 plasmid unnamed1, complete sequence	735766-735795	6	0.8
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	NZ_CP021765	Ralstonia pseudosolanacearum strain CRMRs218 plasmid unnamed, complete sequence	480675-480704	6	0.8
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	NC_017957	Tistrella mobilis KA081020-065 plasmid pTM1, complete sequence	76466-76495	7	0.767
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	NC_018022	Mycolicibacterium chubuense NBB4 plasmid pMYCCH.01, complete sequence	125104-125133	7	0.767
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	MN694699	Marine virus AFVG_250M1158, complete genome	3434-3463	7	0.767
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	NC_014310	Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence	748022-748051	7	0.767
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	NZ_CP022760	Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence	648078-648107	7	0.767
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	NZ_CP022789	Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence	648068-648097	7	0.767
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	NC_019958	Mycobacterium sp. JS623 plasmid pMYCSM02, complete sequence	76045-76074	8	0.733
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	NZ_CP015203	Rhodococcus sp. 008 plasmid pR8L1, complete sequence	574338-574367	8	0.733
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	NZ_CP020568	Kitasatospora aureofaciens strain DM-1 plasmid unnamed1, complete sequence	222438-222467	8	0.733
NC_008699_8	8.1\|375316\|30\|NC_008699\|CRISPRCasFinder	375316-375345	30	NZ_CP044989	Deinococcus sp. AJ005 plasmid p380k, complete sequence	157305-157334	8	0.733

1. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to KM879463 (Arthrobacter phage vB_ArtM-ArV1, complete genome) position: , mismatch: 5, identity: 0.833

ccgggggtggcgggggtgggcggtgtgtcc-	CRISPR spacer
ccgggggtgccgggggtgggc-gtctattcg	Protospacer
********* *********** ** *.*.*

2. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to NZ_CP015231 (Epibacterium mobile F1926 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.8

ccgggggtggcgggggtg---ggcggtgtgtcc	CRISPR spacer
ccgggggtggcggggctgcgcggcggcgag---	Protospacer
*************** **   *****.* *

3. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to NZ_CP021765 (Ralstonia pseudosolanacearum strain CRMRs218 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.8

ccgggggtggcgggggtgggcggtgtgtcc	CRISPR spacer
ccgggggtgccgtgggtgggcggatcgtcg	Protospacer
********* ** **********  .***

4. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to NC_017957 (Tistrella mobilis KA081020-065 plasmid pTM1, complete sequence) position: , mismatch: 7, identity: 0.767

ccgggggtggcgggggtgggcggtgtgtcc	CRISPR spacer
tcgggggtggcgggggtggcgggtgccgca	Protospacer
.******************  ****.  *

5. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to NC_018022 (Mycolicibacterium chubuense NBB4 plasmid pMYCCH.01, complete sequence) position: , mismatch: 7, identity: 0.767

ccgggggtggcgggggtgggcggtgtgtcc	CRISPR spacer
tcgggggtggcgcgggtggccggttcggct	Protospacer
.*********** ****** **** .* *.

6. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to MN694699 (Marine virus AFVG_250M1158, complete genome) position: , mismatch: 7, identity: 0.767

ccgggggtggcgggggtgggcggtgtgtcc	CRISPR spacer
ccggggggggcgggggggggcggcgggggg	Protospacer
******* ******** ******.* *

7. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to NC_014310 (Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence) position: , mismatch: 7, identity: 0.767

ccgggggtggcgggggtgggcggtgtgtcc	CRISPR spacer
gtggcagtggcgcgggtgggcggtgtggcg	Protospacer
 .** .****** ************** *

8. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to NZ_CP022760 (Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

ccgggggtggcgggggtgggcggtgtgtcc	CRISPR spacer
gtggcagtggcgcgggtgggcggtgtggcg	Protospacer
 .** .****** ************** *

9. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to NZ_CP022789 (Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

ccgggggtggcgggggtgggcggtgtgtcc	CRISPR spacer
gtggcagtggcgcgggtgggcggtgtggcg	Protospacer
 .** .****** ************** *

10. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to NC_019958 (Mycobacterium sp. JS623 plasmid pMYCSM02, complete sequence) position: , mismatch: 8, identity: 0.733

ccgggggtggcgggggtgggcggtgtgtcc	CRISPR spacer
gtgggggtggcgggggtgagtggtggcgtc	Protospacer
 .****************.*.****   .*

11. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to NZ_CP015203 (Rhodococcus sp. 008 plasmid pR8L1, complete sequence) position: , mismatch: 8, identity: 0.733

ccgggggtggcgggggtgggcggtgtgtcc	CRISPR spacer
gagggggtggatggggtgggcggtgagctg	Protospacer
  ********  ************* *..

12. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to NZ_CP020568 (Kitasatospora aureofaciens strain DM-1 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

ccgggggtggcgggggtgggcggtgtgtcc	CRISPR spacer
ccgggggtggcgggggtgaccgggtcggtg	Protospacer
******************. ***  .* .

13. spacer 8.1|375316|30|NC_008699|CRISPRCasFinder matches to NZ_CP044989 (Deinococcus sp. AJ005 plasmid p380k, complete sequence) position: , mismatch: 8, identity: 0.733

ccgggggtggcgggggtgggcggtgtgtcc	CRISPR spacer
ccggtggtggcgggggtgggcctgctgctg	Protospacer
**** ****************    **..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

582460 : 602703

Mycobacterium_phage(40.0%)

integrase,tail,transposase

attL 595781:595797|attR 612015:612031

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011754042.1\|582460_585370_-\|tail	phage tail tape measure protein	A0A068F1L4	Mycobacterium_phage	1.4e-31	27.7
WP_011754043.1\|585455_585692_-	hypothetical protein	NA	NA	NA	NA
WP_011754044.1\|585698_586034_-	hypothetical protein	NA	NA	NA	NA
WP_158305622.1\|586030_586426_-	excisionase family DNA-binding protein	NA	NA	NA	NA
WP_041546145.1\|586428_587115_-	hypothetical protein	NA	NA	NA	NA
WP_011754047.1\|587199_588729_-	hypothetical protein	A0A142K7D7	Mycobacterium_phage	5.5e-48	31.8
WP_011754048.1\|588725_589163_-	hypothetical protein	NA	NA	NA	NA
WP_041546146.1\|589295_589544_-	hypothetical protein	NA	NA	NA	NA
WP_011754049.1\|589543_589915_-	hypothetical protein	NA	NA	NA	NA
WP_041546152.1\|590236_590434_-	hypothetical protein	NA	NA	NA	NA
WP_158305623.1\|590430_590571_-	hypothetical protein	NA	NA	NA	NA
WP_041546154.1\|591093_591336_-	hypothetical protein	NA	NA	NA	NA
WP_140403790.1\|591717_591903_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_011754054.1\|591982_592798_+	hypothetical protein	NA	NA	NA	NA
WP_011754055.1\|592797_593883_+\|integrase	site-specific integrase	A0A220NQQ9	Corynebacterium_phage	1.1e-13	25.5
WP_140403791.1\|593882_594476_+	hypothetical protein	NA	NA	NA	NA
WP_011754056.1\|594466_594958_-	YajQ family cyclic di-GMP-binding protein	NA	NA	NA	NA
WP_011754057.1\|595340_596720_-\|integrase	site-specific integrase	NA	NA	NA	NA
595781:595797	attL	NA	NA	NA	NA
WP_011754058.1\|596886_597114_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_011754059.1\|597414_598725_-	hypothetical protein	NA	NA	NA	NA
WP_011754060.1\|598724_599024_-	hypothetical protein	NA	NA	NA	NA
WP_011754061.1\|599140_599677_-	hypothetical protein	NA	NA	NA	NA
WP_011754062.1\|599688_600102_-	single-stranded DNA-binding protein	NA	NA	NA	NA
WP_011754063.1\|600242_600554_+\|transposase	transposase	NA	NA	NA	NA
WP_083768136.1\|600769_601345_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A1B3AZE5	Gordonia_phage	7.8e-24	41.3
WP_140404203.1\|601503_602703_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	2.5e-32	35.1
612015:612031	attR	NA	NA	NA	NA

DBSCAN-SWA_2

614125 : 663173

Mycobacterium_phage(50.0%)

integrase,transposase

attL 623695:623710|attR 656287:656302

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011754069.1\|614125_615679_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_011754070.1\|615675_616455_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.8e-23	31.7
WP_158305625.1\|617359_617776_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_140404164.1\|617905_618304_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011754071.1\|618227_618641_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011754072.1\|618936_620220_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_140404163.1\|620472_620763_+	hypothetical protein	NA	NA	NA	NA
WP_011754074.1\|621281_622454_+	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_011754075.1\|622576_623803_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
623695:623710	attL	NA	NA	NA	NA
WP_011754076.1\|623978_624278_+	Dabb family protein	NA	NA	NA	NA
WP_011754077.1\|624277_625204_+	cyclase family protein	NA	NA	NA	NA
WP_011754078.1\|625235_626420_+	FAD-dependent monooxygenase	NA	NA	NA	NA
WP_011754079.1\|626504_627239_+	SRPBCC family protein	NA	NA	NA	NA
WP_011754080.1\|627273_628125_+	xanthine dehydrogenase family protein subunit M	NA	NA	NA	NA
WP_041547085.1\|628162_628633_+	(2Fe-2S)-binding protein	NA	NA	NA	NA
WP_041547086.1\|628656_631035_+	xanthine dehydrogenase family protein molybdopterin-binding subunit	NA	NA	NA	NA
WP_041547087.1\|631064_631874_+	carbon-nitrogen family hydrolase	NA	NA	NA	NA
WP_193371864.1\|633291_633657_+	hypothetical protein	NA	NA	NA	NA
WP_049774213.1\|633777_634110_-\|transposase	transposase	A0A2P1JR32	Mycobacterium_phage	1.7e-23	58.3
WP_011754084.1\|634391_635381_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_011754085.1\|635377_636376_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_011754086.1\|636372_637611_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_011754088.1\|638468_639644_-	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_140404162.1\|640370_640658_-	hypothetical protein	NA	NA	NA	NA
WP_011754089.1\|641062_641557_-	(2Fe-2S)-binding protein	A0A0P0IVM8	Acinetobacter_phage	1.5e-23	40.3
WP_011754090.1\|641553_642441_-	xanthine dehydrogenase family protein subunit M	NA	NA	NA	NA
WP_011754091.1\|642622_643873_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_041547092.1\|643943_644627_-	DsbA family protein	NA	NA	NA	NA
WP_011754093.1\|644689_645766_-	ABC transporter permease	NA	NA	NA	NA
WP_011754094.1\|645762_647367_-	sugar ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	6.9e-09	25.1
WP_011754095.1\|647540_649913_-	xanthine dehydrogenase family protein molybdopterin-binding subunit	NA	NA	NA	NA
WP_140404161.1\|650143_651214_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_011754097.1\|651307_651658_+	DUF861 domain-containing protein	NA	NA	NA	NA
WP_011754099.1\|654930_657102_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
656287:656302	attR	NA	NA	NA	NA
WP_011754100.1\|657098_658139_-	EamA family transporter	NA	NA	NA	NA
WP_049774215.1\|658193_659132_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_049774216.1\|659377_659788_+	DUF861 domain-containing protein	NA	NA	NA	NA
WP_011754103.1\|660056_661448_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_041546178.1\|661718_662045_+\|transposase	transposase	A0A2P1JR43	Mycobacterium_phage	7.3e-27	60.4
WP_049774219.1\|662041_662695_+\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	3.7e-38	58.9
WP_041546180.1\|662879_663173_-\|transposase	IS3 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_008699

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection