CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NC_008704	Mycobacterium sp. KMS plasmid pMKMS02, complete sequence	0 crisprs	csf1gr8,csf4gr11,csf2gr7,DEDDh	0	2
NC_008703	Mycobacterium sp. KMS plasmid pMKMS01, complete sequence	0 crisprs	csa3	0	1
NC_008705	Mycobacterium sp. KMS, complete sequence	4 crisprs	cas3,csa3,casR,WYL,cas4,DEDDh,DinG	1	5

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

25554 : 65394

Mycobacterium_phage(37.5%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011558258.1\|25554_26802_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	5.8e-80	42.4
WP_011562807.1\|27535_27946_-	hypothetical protein	NA	NA	NA	NA
WP_167535230.1\|28211_28382_+	hypothetical protein	NA	NA	NA	NA
WP_011562809.1\|28742_29420_-	hypothetical protein	NA	NA	NA	NA
WP_011562810.1\|29416_30136_-	hypothetical protein	NA	NA	NA	NA
WP_011562811.1\|30135_33330_-	hypothetical protein	NA	NA	NA	NA
WP_011562812.1\|33326_33719_-	hypothetical protein	NA	NA	NA	NA
WP_011767984.1\|34184_34481_+	hypothetical protein	NA	NA	NA	NA
WP_011562816.1\|36282_36618_-\|transposase	transposase	Q8W6R2	Burkholderia_virus	3.2e-17	47.6
WP_109750939.1\|36598_37798_-\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	5.8e-37	31.7
WP_011558261.1\|39200_40520_-\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	3.4e-232	92.5
WP_083775484.1\|40897_41269_-\|transposase	transposase	NA	NA	NA	NA
WP_011562981.1\|41273_42023_-	IclR family transcriptional regulator	NA	NA	NA	NA
WP_041310550.1\|42070_42886_+	2-keto-4-pentenoate hydratase	NA	NA	NA	NA
WP_011562979.1\|42882_43830_+	acetaldehyde dehydrogenase (acetylating)	G8DDL4	Micromonas_pusilla_virus	1.2e-32	32.4
WP_011562978.1\|43826_44876_+	4-hydroxy-2-oxovalerate aldolase	E5EQ69	Micromonas_sp._RCC1109_virus	2.9e-40	31.0
WP_011562976.1\|45618_46518_+	alpha/beta fold hydrolase	A0A249XTU1	Mycobacterium_phage	2.1e-07	34.2
WP_011562975.1\|46517_47834_+	aromatic ring-hydroxylating dioxygenase subunit alpha	NA	NA	NA	NA
WP_011562974.1\|47836_48349_+	aromatic-ring-hydroxylating dioxygenase subunit beta	NA	NA	NA	NA
WP_011562973.1\|48388_49618_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_011562972.1\|49637_50606_+	extradiol ring-cleavage dioxygenase	NA	NA	NA	NA
WP_011767986.1\|51205_51955_+	class II aldolase/adducin family protein	NA	NA	NA	NA
WP_049771653.1\|52059_52623_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_041310557.1\|52789_53668_-	NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_011562968.1\|53762_54206_-	cupin domain-containing protein	NA	NA	NA	NA
WP_011562967.1\|54306_54864_-	3-phenylpropionate/cinnamic acid dioxygenase subunit beta	NA	NA	NA	NA
WP_011562966.1\|54860_56276_-	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_011562965.1\|56523_56721_-	ferredoxin	NA	NA	NA	NA
WP_011562964.1\|56751_57798_-	hypothetical protein	NA	NA	NA	NA
WP_011562963.1\|57784_58243_-	DNA-binding protein	NA	NA	NA	NA
WP_011562962.1\|58279_59446_-	transporter	NA	NA	NA	NA
WP_011562961.1\|59442_60696_-	CoA transferase	NA	NA	NA	NA
WP_011562960.1\|60748_61780_-	2,3-butanediol dehydrogenase	NA	NA	NA	NA
WP_011562959.1\|61886_62429_-	aromatic-ring-hydroxylating dioxygenase subunit beta	NA	NA	NA	NA
WP_049771638.1\|62425_63760_-	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_011558261.1\|64074_65394_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	3.4e-232	92.5

DBSCAN-SWA_2

165116 : 204779

Mycobacterium_phage(33.33%)

transposase,protease,integrase

attL 182291:182310|attR 186237:186256

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011562855.1\|165116_166499_-\|protease	type VII secretion-associated serine protease mycosin	V5UPA7	Mycobacterium_phage	4.7e-75	40.1
WP_011562854.1\|166498_167917_-	type VII secretion integral membrane protein EccD	NA	NA	NA	NA
WP_153266311.1\|167919_169071_-	AAA family ATPase	NA	NA	NA	NA
WP_011562852.1\|169608_170439_-	ESX secretion-associated protein EspG	NA	NA	NA	NA
WP_011562851.1\|170431_170671_-	hypothetical protein	NA	NA	NA	NA
WP_011562850.1\|171299_172958_+	ParB/RepB/Spo0J family partition protein	I3NLC2	Bifidobacterium_phage	1.9e-09	29.1
WP_011562849.1\|173082_173952_+	ParA family protein	NA	NA	NA	NA
WP_011562848.1\|173944_174196_+	hypothetical protein	NA	NA	NA	NA
WP_167535236.1\|174427_174598_+	hypothetical protein	NA	NA	NA	NA
WP_011562847.1\|174630_174990_+	hypothetical protein	NA	NA	NA	NA
WP_011562846.1\|175265_176705_+	recombinase family protein	A0A2D1GQ20	Mycobacterium_phage	6.9e-61	37.6
WP_041310603.1\|176924_177881_+	ATP-binding protein	A0A0R6PCP6	Moraxella_phage	2.2e-10	31.5
WP_041310606.1\|177877_180490_+	S8 family peptidase	NA	NA	NA	NA
WP_011562843.1\|180787_181225_-	hypothetical protein	NA	NA	NA	NA
182291:182310	attL	NA	NA	NA	NA
WP_041310610.1\|182416_183526_+\|integrase	site-specific integrase	A0A220NQQ9	Corynebacterium_phage	1.2e-12	33.3
WP_011562840.1\|183570_185736_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_011562839.1\|185725_186136_+	hypothetical protein	NA	NA	NA	NA
WP_011562837.1\|186473_187550_-	hypothetical protein	NA	NA	NA	NA
186237:186256	attR	NA	NA	NA	NA
WP_109750939.1\|188279_189479_-\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	5.8e-37	31.7
WP_085975523.1\|191310_192473_-\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	9.3e-32	32.2
WP_011562829.1\|192524_193118_-	hypothetical protein	NA	NA	NA	NA
WP_011562828.1\|193110_194553_-	cell division protein FtsK	G1FGP1	Mycobacterium_phage	6.2e-09	28.1
WP_011562827.1\|194642_194981_-	hypothetical protein	NA	NA	NA	NA
WP_011562825.1\|196025_196493_+	NUDIX domain-containing protein	NA	NA	NA	NA
WP_041310618.1\|196502_197039_-	HD domain-containing protein	NA	NA	NA	NA
WP_011562823.1\|197586_198156_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_011562822.1\|198245_198710_-	hypothetical protein	NA	NA	NA	NA
WP_011562821.1\|198706_201544_-	RND family transporter	NA	NA	NA	NA
WP_011562820.1\|201540_201984_-	hypothetical protein	NA	NA	NA	NA
WP_109750939.1\|203579_204779_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	5.8e-37	31.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_008703

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

54898 : 100417

Mycobacterium_phage(27.27%)

integrase,transposase

attL 40741:40758|attR 94471:94488

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
40741:40758	attL	NA	NA	NA	NA
WP_011767755.1\|54898_55903_-\|transposase	IS1595-like element ISMfl2 family transposase	NA	NA	NA	NA
WP_083775478.1\|55987_56695_+	MMPL family transporter	NA	NA	NA	NA
WP_011767757.1\|56828_57722_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_083775473.1\|57906_58863_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_110797900.1\|58886_59784_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_011767759.1\|59819_60449_-	hypothetical protein	NA	NA	NA	NA
WP_041321950.1\|60461_60791_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011767761.1\|60790_61873_-\|integrase	tyrosine-type recombinase/integrase	A0A142KCU7	Gordonia_phage	3.9e-08	26.4
WP_041321953.1\|63000_63456_+	hypothetical protein	NA	NA	NA	NA
WP_041321956.1\|63471_64428_+	hypothetical protein	A0A1P8D5M4	Corynebacterium_phage	3.7e-26	32.4
WP_011767765.1\|64624_66574_+	hypothetical protein	NA	NA	NA	NA
WP_041321958.1\|66794_67733_+	DNA ligase	A0A076GD42	Sinorhizobium_phage	9.8e-32	35.4
WP_011767767.1\|67733_69290_-	serine/threonine protein kinase	A0A1B1IUU3	uncultured_Mediterranean_phage	5.1e-17	32.5
WP_011767768.1\|69336_69747_-	ribonuclease	NA	NA	NA	NA
WP_011767769.1\|69737_69965_-	hypothetical protein	NA	NA	NA	NA
WP_041321962.1\|70109_71066_+	DUF4226 domain-containing protein	NA	NA	NA	NA
WP_153266297.1\|71097_71361_-	hypothetical protein	NA	NA	NA	NA
WP_041322043.1\|71491_71824_+	hypothetical protein	NA	NA	NA	NA
WP_011767773.1\|71902_72607_-	hypothetical protein	NA	NA	NA	NA
WP_011767774.1\|73061_74261_+	helix-turn-helix transcriptional regulator	V5UNB6	Mycobacterium_phage	1.6e-10	37.8
WP_011767775.1\|74266_75184_+	hypothetical protein	NA	NA	NA	NA
WP_011767776.1\|75289_75598_+	hypothetical protein	NA	NA	NA	NA
WP_049772852.1\|76224_77379_-	MFS transporter	NA	NA	NA	NA
WP_049772853.1\|77467_77971_-	hypothetical protein	NA	NA	NA	NA
WP_011767779.1\|78225_78567_-	MerR family DNA-binding protein	NA	NA	NA	NA
WP_011767780.1\|78693_79509_-	AAA family ATPase	NA	NA	NA	NA
WP_013470158.1\|79505_80966_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A2H4JEQ4	uncultured_Caudovirales_phage	3.1e-08	24.8
WP_011767782.1\|81056_81677_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_083775474.1\|81869_81980_-	MerR family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_163886445.1\|85640_86687_+	DUF2637 domain-containing protein	V5UP70	Mycobacterium_phage	3.4e-17	43.9
WP_041321969.1\|87426_87870_+	hypothetical protein	NA	NA	NA	NA
WP_011767787.1\|87873_88710_-	ParB N-terminal domain-containing protein	A0A1C9EHY8	Gordonia_phage	1.4e-05	30.3
WP_011767788.1\|88709_89423_-	ParA family protein	D3JZ99	Mycobacterium_phage	2.0e-05	32.1
WP_011767789.1\|90175_90928_+	hypothetical protein	NA	NA	NA	NA
WP_011767790.1\|91957_92887_+	ParA family protein	F0PIG8	Enterococcus_phage	9.1e-06	27.3
WP_011767791.1\|92883_93576_+	hypothetical protein	NA	NA	NA	NA
WP_011767792.1\|93610_94315_-	transcription factor WhiB	NA	NA	NA	NA
WP_041321975.1\|94299_94560_+	hypothetical protein	NA	NA	NA	NA
94471:94488	attR	NA	NA	NA	NA
WP_083775475.1\|96210_96501_-	transcription factor WhiB	NA	NA	NA	NA
WP_153266299.1\|96712_97426_+	transcriptional regulator	NA	NA	NA	NA
WP_011767797.1\|98040_99171_+	lytic transglycosylase	G9FHI5	Rhodococcus_phage	1.2e-12	34.9
WP_167535226.1\|99721_100417_+\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NC_008705

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CRISPR-Cas detection and classification

Crispr_ID: NC_008705_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008705_1

4088587-4088690

Orphan

Consensus_repeat	Method
GCGCTGAGGGCCTGGGCAAGTCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008705_1

>merge|NC_008705|1|4088587-4088690|CRISPRCasFinder
GCGCTGAGGGCCTGGGCAAGTCTCCAATGCATTGGACACTTCATCCTCGGTCAGTTGAGTCGTCGTGACTCACCTCCCCAGCGCTGAGGGCCTGGGCCAAGTCT

>NC_008705|1|1|4088587-4088690|CRISPRCasFinder
GCGCTGAGGGCCTGGGCAAGTCTC	CAATGCATTGGACACTTCATCCTCGGTCAGTTGAGTCGTCGTGACTCACCTCCCCA
GCGCTGAGGGCCTGGGCCAAGTCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008705.1\|WP_011561179.1\|4085954_4086695_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|181349
NC_008705.1\|WP_011561184.1\|4089280_4089595_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_041309765.1\|4088168_4088354_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561191.1\|4092703_4092982_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561173.1\|4080868_4081690_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561188.1\|4091521_4092169_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561183.1\|4088921_4089281_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|366837
NC_008705.1\|WP_011561189.1\|4092171_4092390_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561185.1\|4089611_4089941_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561175.1\|4082501_4083077_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_008705.1\|WP_011561190.1\|4092367_4092619_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561174.1\|4081686_4082397_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011768330.1\|4085193_4085958_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187629
NC_008705.1\|WP_011561176.1\|4083078_4083951_-\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl\|CDD\|224617
NC_008705.1\|WP_011561186.1\|4090211_4091069_-\|phage-major-capsid-protein	unknown	unknown	gnl\|CDD\|377449
NC_008705.1\|WP_011561182.1\|4087753_4088128_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561181.1\|4087067_4087730_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561177.1\|4083963_4085115_-\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NC_008705.1\|WP_011561187.1\|4091297_4091522_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561192.1\|4093007_4093403_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_008705.1\|WP_011561179.1\|4085954_4086695_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|181349	PRK08278, PRK08278, SDR family oxidoreductase.	7.74873e-65
NC_008705.1\|WP_011768330.1\|4085193_4085958_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187629	cd05371, HSD10-like_SDR_c, 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs. HSD10, also known as amyloid-peptide-binding alcohol dehydrogenase (ABAD), was previously identified as a L-3-hydroxyacyl-CoA dehydrogenase, HADH2. In fatty acid metabolism, HADH2 catalyzes the third step of beta-oxidation, the conversion of a hydroxyl to a keto group in the NAD-dependent oxidation of L-3-hydroxyacyl CoA. In addition to alcohol dehydrogenase and HADH2 activites, HSD10 has steroid dehydrogenase activity. Although the mechanism is unclear, HSD10 is implicated in the formation of amyloid beta-petide in the brain (which is linked to the development of Alzheimer's disease). Although HSD10 is normally concentrated in the mitochondria, in the presence of amyloid beta-peptide it translocates into the plasma membrane, where it's action may generate cytotoxic aldehydes and may lower estrogen levels through its use of 17-beta-estradiol as a substrate. HSD10 is a member of the SRD family, but differs from other SDRs by the presence of two insertions of unknown function. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.10065e-92
NC_008705.1\|WP_011561176.1\|4083078_4083951_-\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl\|CDD\|224617	COG1703, ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism].	7.78081e-93
NC_008705.1\|WP_011561186.1\|4090211_4091069_-\|phage-major-capsid-protein	gnl\|CDD\|377449	pfam05065, Phage_capsid, Phage capsid family. Family of bacteriophage hypothetical proteins and capsid proteins.	2.47225e-35
NC_008705.1\|WP_011561183.1\|4088921_4089281_-\|HNH-endonuclease	gnl\|CDD\|366837	pfam01844, HNH, HNH endonuclease. His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.	1.72489e-06
NC_008705.1\|WP_011561177.1\|4083963_4085115_-\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.90866e-147
NC_008705.1\|WP_011561175.1\|4082501_4083077_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.21884e-12

>NC_008705.1|WP_041309765.1|4088168_4088354_-|hypothetical-protein
MYAAAAKERMLAGKKDPVANSRQGSQRERRSDEQAAKAVEASDRSVLFPVWDMPLTSTDEN
>NC_008705.1|WP_011561182.1|4087753_4088128_-|hypothetical-protein
MSRIPLWDRAIHITSRTLSGMTINMSIPTRDEIENLSDTDHKVLENRLRRAAERQDLRLLKSRARDPRSRLYGTYMLTDQNNGVVFADHSTGRGYGLDLVDVAEWLFGDREQFAVQADTREALR
>NC_008705.1|WP_011561181.1|4087067_4087730_-|hypothetical-protein
MDKKQATVYDKEIRRLVGKIQDDLDTLAHLINQMLEGQAHLALGFKTPQAYLQDVFRIDGVSRVIEQRRPVVAMLTQKGLSQRAIADIVGVSVGTVVNDQAASGAQKLSTSSEDRVIGRDGKSYPATKPKPEPEVSDDEIIDYQAAQDDFNRLTSSMFAAKRKAQDALSLALHLRGFNEDEKRSIVADVADEVIDVFNAIKDAAKGRSMDAELRKLLDQG
>NC_008705.1|WP_011561179.1|4085954_4086695_+|SDR-family-NAD(P)-dependent-oxidoreductase
MSLAGKVAFVAGASRGIGATVAKALAAEGAAVAVAARSEQPGKLPGTIHTVAESITASGGRALPVSCDVTDESSVETAVAETVSEFGGIDILVANAGVLWLGPIESTPLKRWQLCLNVNLTGVFLVTKAVIPHVRARGGGSLIAVTTTGVTMTDQGSNAYWVSKAAAERLYLGLAADLRADNIAVNCLSPSRVVLTEGWQAGGAGMEIPPEMVEPPEAMGRAAVLLAAQDASGITGTIQRSEEVVR
>NC_008705.1|WP_011768330.1|4085193_4085958_+|SDR-family-NAD(P)-dependent-oxidoreductase
MQIAGSSAIVVGGAGGLGEATVRRLQGAGAKVVVADLADEKGAALEKELGVRYVRTDATSEESVNAAIAEAESMGPLRISVDTHGGPASGGRLIGKDGSPLDLDGFKKTIEFYLTAVFNVMRLTAAAIAKSEPLEEGGRGVIVNTASIAGYEGQIGQLPYSAAKGGVLGMTLVAARDLSPLGIRVCTIAPGTINTPAYGKAADQLEQYWGPQVPFPKRMGRSTEYAQLAQSIIENDYLNGEIIRLDGALRFPPK
>NC_008705.1|WP_011561177.1|4083963_4085115_-|thiolase-family-protein
MPEAVIVSALRTPIGTAMKGTLRDTDAYRLAEHVVAAAAEDLPTGQIDDVVLGEGLYGGGVIARHAAITAGLISVPGLSNNRHCAAGQAAVQSAAASIRAGMDQLVIAGGVNSASTTPRFTRRASSAKDAAMLDWFPPTHPDRADAPNMDMSITVGWNAAVRAGVSREEMDQWALDSHRKAIQAIDEGRFKEEIVPIDTPYGLFDTDEHPRRDTSIEKLASLKPLHPEIEGFSITAGNACGANDGAAVLALASDRLGLPALGAVKAWASVGVDPAFTGLAPVEAIPKALKRAGISLSDVDLFEINEAFAAMCVATVKMLDIDPAKVNVSGSGCSLGHPVAATGARMLVTLVHELRRRGGGIGVAAMCAGGGMGSATVIEVPAP
>NC_008705.1|WP_011561176.1|4083078_4083951_-|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MDVDELIAAARNGSTRAAGRLLSLVEGTRRDEVLAALAPHRARVVGLTGPPGAGKSTTVAALVTAYRQRGLRVAVLAVDPSSPYSGGALLGDRIRMAAHINDPDVLIRSVATRGHLGGLAAAVPAAIRLLAALAFDLIILETVGVGQSEIEIAAIADPTVVVLNPGAGDAVQAAKAGLLEVADIVVVNKADRDGADQTVRDLRGEVSVPILKLVAAQGEGVPELVDTIDAHHRDDTAQRRTARARTQILSLAHTLLRTHPELDRLAELVAEGTHDPYGAAEQLFAVRIES
>NC_008705.1|WP_011561175.1|4082501_4083077_+|TetR/AcrR-family-transcriptional-regulator
MPPVHDHPAVRRSAAQVRVLDAALDLIAENGVGGTSLQMIADRIGVTKAAVYHQFKTKEEIVIALTERELAGLEDALAAAEAEENRSRAREVLLTRVVDLAINRRRVASVLQFDPVIVRLLAEHEPFQRFIDRLYSAMLGNETGTRARVHAAMLSGVISVAVMHPLVVDIDDDTLRDEVLQTMRRIVDLPG
>NC_008705.1|WP_011561174.1|4081686_4082397_-|hypothetical-protein
MTRRVDGEVILLWTLPAVVLIWVSAFFLFPGFVHPMSPTMSAEEVAAFYRDETARIRYSMILFNWFGVGLIPLVMLIVVQVRRMAHRTPILSYSLLACSAGPPTLFLVANMFWLLGAFRPERAPELTQLFNDLAWITFTILVPYLIAQCLLLALAIYWDHQAQPVFTPWVAHFNLLVAAALAPAAFTALAWTGPFAWDGVLSFWLKNVAIALWIVVMGLVVAQTIRRQRTQERVVA
>NC_008705.1|WP_011561173.1|4080868_4081690_-|hypothetical-protein
MSPPIVEPPPGSVIGRFFWNVRHHPKKELWFAWWVMVVFYQLYGVLFFLVTRVQPPPSPAWDIPTVVQWFDDRHLGILAGFGVVFLISGMCGPMNALLAYSMRRMSVSPIFGYSYLAMYALSAIPGMLVMAIAMTVAALRPDRDPELIHWLYDFAFLSFSGTMGVFLIGSLVWMVAILLDKNRVLPKWFGYLGLCNALTEVVVAPAWMFQRGVFAWNGAIAWWINMVVFLLYTAAFIMLLRRMIQREDFGTGPLPDLPAEGIREDSDTVEAVR
>NC_008705.1|WP_011561183.1|4088921_4089281_-|HNH-endonuclease
MPRAPKMCGRNGCRTIVHPPRKHCPEHSGWNTSPRTASAAATERSYWRTVIRPQALARDNHQCQLRFPGICTGHATEVDHIVAVSDGGADELDNARSACRRCHARRTAQDAARASHRAR
>NC_008705.1|WP_011561184.1|4089280_4089595_-|hypothetical-protein
MIGATGSPQQAAEKVAADLAALAEKLDVLRERPDWHHDDVLAPALAALTSAAKSTPAQRAKRRAAKDEARADELARAKAARNRFRTPASDRRTGGPNAVKARRS
>NC_008705.1|WP_011561185.1|4089611_4089941_-|hypothetical-protein
MPRNRFKPGAEHPNWRGDAASYAAIHYRLRTTLGSARDHRCVDCGEPAKHWSFSGCESEIPRRRNEAGRVISPPYCPHPEHFSPRCIPCHWRHDGAADRLNKKPAKKSA
>NC_008705.1|WP_011561186.1|4090211_4091069_-|phage-major-capsid-protein
MAFLSTSAGSILKPEEVHDLIVQPTQEQSVAMQTATVVPTSSAEFRFPVVVEDAAAQWLSEGEEIPLTDPTVDEVVARPKKIASLTKVSRELAEDSSPEATALVGASVARDMARRIDAAWFAASTAKGPAGLASLIGTAQSVAGGAYTNLDALAEALSLIEDVGGNPTAFVSNSSTVLALSKLKKTSDSNEPLLSPNLATGATQRIERQLLGVRLHSTPDTNLEDDVIWAYDQSKVFVVLRRDVDLAVDQSAFFTSDSLAVRCTMRIDFAFPHPQSVVRVGPDGS
>NC_008705.1|WP_011561187.1|4091297_4091522_-|hypothetical-protein
MPASKRSKRQIAIQRSQRRHRPDDPAMKPQPWHPLPDGDVRPFVPRNQRNATRDERGRVRNTEEVHDELRRLNP
>NC_008705.1|WP_011561188.1|4091521_4092169_-|hypothetical-protein
MPESSTTATDSGSSTGAEGGAQHQDSTGRELPADSPEATERQDNPASEAPGTDTGGGAGEPVADSRQVSDDPPADLQEGEPDPADDGKPDREAAKYRRERNEARAEVDRLRATVETFQRAEVERLAALKLIDGRDVWAAGAKLADLLADDGTVDIEKVSAAAQEIAATRRHWAKQAAAPASVVTGNQKPGYGDDEKTTWGDVFQRVRNGVAPEDR
>NC_008705.1|WP_011561189.1|4092171_4092390_-|hypothetical-protein
MLWLAVIDRDYPAVDRALDMLPADPEVRAIAITLCEIGIAIEPRLRCDAARDQALTQLALLDHTFKMLTGRD
>NC_008705.1|WP_011561190.1|4092367_4092619_-|hypothetical-protein
MRCPLCSRLTWLDRLPSTRSVPAHCNPHALLRLETHTLRRTIEHHRDQRPEAAARRAFIAQCRAQHLADHDQGGADDAVAGGD
>NC_008705.1|WP_011561191.1|4092703_4092982_-|hypothetical-protein
MPANIFRLELNERDYQRVGAALAALVHCDARGIADVLKDATEAKRGFHYHVAVLQTLAHRMGLDGPDRDELLANLQQEIAELARRAEAGGDD
>NC_008705.1|WP_011561192.1|4093007_4093403_-|hypothetical-protein
MTERSGLDRPNPHLNGWSTNDVVRLLLSLAEELQNLDAELSGLERDAVTKAEQLNVAQAKALLTATGKTVGEREAQALLATEAERLAARLAEINVKATKRRVETLRMRIDIGRTVCATLRSETELERSSWR

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Crispr_ID: NC_008705_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008705_2

4533157-4533261

Unclear

Consensus_repeat	Method
GAGACTTGGCCCAGGCCCTCAGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008705_2

>merge|NC_008705|2|4533157-4533261|CRISPRCasFinder
GAGACTTGGCCCAGGCCCTCAGCGCTGGGGAGGTGAGTCACGACGACTCAACTGACCGAGGATGAAGTGTCCAATGCATTGGAGACTTGCCCAGGCCCTCAGCGC

>NC_008705|2|2|4533157-4533261|CRISPRCasFinder
GAGACTTGGCCCAGGCCCTCAGCGC	TGGGGAGGTGAGTCACGACGACTCAACTGACCGAGGATGAAGTGTCCAATGCATT
GGAGACTTGCCCAGGCCCTCAGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008705.1\|WP_011561182.1\|4533719_4534094_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561181.1\|4534117_4534780_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561186.1\|4530778_4531636_+\|phage-major-capsid-protein	unknown	unknown	gnl\|CDD\|377449
NC_008705.1\|WP_011561191.1\|4528865_4529144_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561613.1\|4536530_4537316_+\|diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|376615
NC_008705.1\|WP_011561185.1\|4531906_4532236_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561184.1\|4532252_4532567_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561188.1\|4529678_4530326_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_041309765.1\|4533493_4533679_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561189.1\|4529457_4529676_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561192.1\|4528444_4528840_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561612.1\|4535785_4536490_+\|membrane-protein	unknown	unknown	gnl\|CDD\|223505
NC_008705.1\|WP_011561187.1\|4530325_4530550_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_041309833.1\|4539230_4540169_-\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326
NC_008705.1\|WP_011561616.1\|4540161_4540662_-\|DUF501-domain-containing-protein	unknown	unknown	gnl\|CDD\|224424
NC_008705.1\|WP_011561183.1\|4532566_4532926_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|366837
NC_008705.1\|WP_011561614.1\|4537689_4539234_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|224875
NC_008705.1\|WP_011561190.1\|4529228_4529480_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561611.1\|4535314_4535782_+\|DUF4383-domain-containing-protein	unknown	unknown	gnl\|CDD\|379556
NC_008705.1\|WP_011768358.1\|4537312_4537681_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_008705.1\|WP_011561612.1\|4535785_4536490_+\|membrane-protein	gnl\|CDD\|223505	COG0428, COG0428, Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism].	0.00022869
NC_008705.1\|WP_011561614.1\|4537689_4539234_+\|radical-SAM-protein	gnl\|CDD\|224875	COG1964, COG1964, Predicted Fe-S oxidoreductases [General function prediction only].	1.0911e-31
NC_008705.1\|WP_011561186.1\|4530778_4531636_+\|phage-major-capsid-protein	gnl\|CDD\|377449	pfam05065, Phage_capsid, Phage capsid family. Family of bacteriophage hypothetical proteins and capsid proteins.	2.47225e-35
NC_008705.1\|WP_011561613.1\|4536530_4537316_+\|diacylglyceryl-transferase	gnl\|CDD\|376615	pfam01790, LGT, Prolipoprotein diacylglyceryl transferase.	1.67178e-34
NC_008705.1\|WP_041309833.1\|4539230_4540169_-\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	4.78204e-97
NC_008705.1\|WP_011561183.1\|4532566_4532926_+\|HNH-endonuclease	gnl\|CDD\|366837	pfam01844, HNH, HNH endonuclease. His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.	1.72489e-06
NC_008705.1\|WP_011561611.1\|4535314_4535782_+\|DUF4383-domain-containing-protein	gnl\|CDD\|379556	pfam14325, DUF4383, Domain of unknown function (DUF4383). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 137 and 164 amino acids in length.	2.03737e-32
NC_008705.1\|WP_011561616.1\|4540161_4540662_-\|DUF501-domain-containing-protein	gnl\|CDD\|224424	COG1507, COG1507, Uncharacterized conserved protein [Function unknown].	3.43903e-87

>NC_008705.1|WP_011561183.1|4532566_4532926_+|HNH-endonuclease
MPRAPKMCGRNGCRTIVHPPRKHCPEHSGWNTSPRTASAAATERSYWRTVIRPQALARDNHQCQLRFPGICTGHATEVDHIVAVSDGGADELDNARSACRRCHARRTAQDAARASHRAR
>NC_008705.1|WP_011561184.1|4532252_4532567_+|hypothetical-protein
MIGATGSPQQAAEKVAADLAALAEKLDVLRERPDWHHDDVLAPALAALTSAAKSTPAQRAKRRAAKDEARADELARAKAARNRFRTPASDRRTGGPNAVKARRS
>NC_008705.1|WP_011561185.1|4531906_4532236_+|hypothetical-protein
MPRNRFKPGAEHPNWRGDAASYAAIHYRLRTTLGSARDHRCVDCGEPAKHWSFSGCESEIPRRRNEAGRVISPPYCPHPEHFSPRCIPCHWRHDGAADRLNKKPAKKSA
>NC_008705.1|WP_011561186.1|4530778_4531636_+|phage-major-capsid-protein
MAFLSTSAGSILKPEEVHDLIVQPTQEQSVAMQTATVVPTSSAEFRFPVVVEDAAAQWLSEGEEIPLTDPTVDEVVARPKKIASLTKVSRELAEDSSPEATALVGASVARDMARRIDAAWFAASTAKGPAGLASLIGTAQSVAGGAYTNLDALAEALSLIEDVGGNPTAFVSNSSTVLALSKLKKTSDSNEPLLSPNLATGATQRIERQLLGVRLHSTPDTNLEDDVIWAYDQSKVFVVLRRDVDLAVDQSAFFTSDSLAVRCTMRIDFAFPHPQSVVRVGPDGS
>NC_008705.1|WP_011561187.1|4530325_4530550_+|hypothetical-protein
MPASKRSKRQIAIQRSQRRHRPDDPAMKPQPWHPLPDGDVRPFVPRNQRNATRDERGRVRNTEEVHDELRRLNP
>NC_008705.1|WP_011561188.1|4529678_4530326_+|hypothetical-protein
MPESSTTATDSGSSTGAEGGAQHQDSTGRELPADSPEATERQDNPASEAPGTDTGGGAGEPVADSRQVSDDPPADLQEGEPDPADDGKPDREAAKYRRERNEARAEVDRLRATVETFQRAEVERLAALKLIDGRDVWAAGAKLADLLADDGTVDIEKVSAAAQEIAATRRHWAKQAAAPASVVTGNQKPGYGDDEKTTWGDVFQRVRNGVAPEDR
>NC_008705.1|WP_011561189.1|4529457_4529676_+|hypothetical-protein
MLWLAVIDRDYPAVDRALDMLPADPEVRAIAITLCEIGIAIEPRLRCDAARDQALTQLALLDHTFKMLTGRD
>NC_008705.1|WP_011561190.1|4529228_4529480_+|hypothetical-protein
MRCPLCSRLTWLDRLPSTRSVPAHCNPHALLRLETHTLRRTIEHHRDQRPEAAARRAFIAQCRAQHLADHDQGGADDAVAGGD
>NC_008705.1|WP_011561191.1|4528865_4529144_+|hypothetical-protein
MPANIFRLELNERDYQRVGAALAALVHCDARGIADVLKDATEAKRGFHYHVAVLQTLAHRMGLDGPDRDELLANLQQEIAELARRAEAGGDD
>NC_008705.1|WP_011561192.1|4528444_4528840_+|hypothetical-protein
MTERSGLDRPNPHLNGWSTNDVVRLLLSLAEELQNLDAELSGLERDAVTKAEQLNVAQAKALLTATGKTVGEREAQALLATEAERLAARLAEINVKATKRRVETLRMRIDIGRTVCATLRSETELERSSWR
>NC_008705.1|WP_041309765.1|4533493_4533679_+|hypothetical-protein
MYAAAAKERMLAGKKDPVANSRQGSQRERRSDEQAAKAVEASDRSVLFPVWDMPLTSTDEN
>NC_008705.1|WP_011561182.1|4533719_4534094_+|hypothetical-protein
MSRIPLWDRAIHITSRTLSGMTINMSIPTRDEIENLSDTDHKVLENRLRRAAERQDLRLLKSRARDPRSRLYGTYMLTDQNNGVVFADHSTGRGYGLDLVDVAEWLFGDREQFAVQADTREALR
>NC_008705.1|WP_011561181.1|4534117_4534780_+|hypothetical-protein
MDKKQATVYDKEIRRLVGKIQDDLDTLAHLINQMLEGQAHLALGFKTPQAYLQDVFRIDGVSRVIEQRRPVVAMLTQKGLSQRAIADIVGVSVGTVVNDQAASGAQKLSTSSEDRVIGRDGKSYPATKPKPEPEVSDDEIIDYQAAQDDFNRLTSSMFAAKRKAQDALSLALHLRGFNEDEKRSIVADVADEVIDVFNAIKDAAKGRSMDAELRKLLDQG
>NC_008705.1|WP_011561611.1|4535314_4535782_+|DUF4383-domain-containing-protein
MARRPTLMAVQGAALIVGTGYLLLGALGFLPGVTTNHERLEWIGHQSDALLFGVFATSGLHNVLHLLLGAAGMFCARTYAASRAYLLAGGVALLGVWFYRAGSGHSGIAEVFPLNRADNWLHFALGVVMLVLALTLAAQHDPTKPRSRPRAKSRA
>NC_008705.1|WP_011561612.1|4535785_4536490_+|membrane-protein
MLGALLWGLVAASSLIVGALAGVARDWNRHLIGLVLGFGAGALVAGISFELAEEGFRVGGALSVSLGLAAGAVTFFIADHLVDRVGNGKKTTAGIPLLLGALLDGIPEQAVLGIGIAAGGAVSPALLTAIFVSNLPEAVGSASDLRGAGHRVKGIVLGWTAIALLCAAATVGGYQLREIAGASLQGGIDGFAAGALLVMLVGSMIPEATEKAREQAGLAAVLGFALAAGLSLAA
>NC_008705.1|WP_011561613.1|4536530_4537316_+|diacylglyceryl-transferase
MTPEWHLGPVAVPVHGVFVGLGVLAALVVFVAEARRRGAVNEQSVVAASGALVGGAIGMRLSGWARHLDLTANPSLAEAWQFGSRSILGGLLGAYLGVLVAKRIGGYRGKTGDLFAPAVALGITVGRIGCHLTEAPGRPTTLPWGIHAPATTPDCPGCLTGQAMHPSFLYEIAFQLAAFVILLWLRDRISHPGELFVLYIAGYATFRFLVEFTRANETVWLDLTRPQWFLLPSLLLIGIRLWYGHRRGYYRSAAHQQEVRA
>NC_008705.1|WP_011768358.1|4537312_4537681_+|hypothetical-protein
MTHPPGPPYPGGYGYPAPPPQPPKKISIGMVFVGAPVYVALNSLLGFLAFIIASSSTDSANIILGAAAVMLALIAFGGGAALLTVRNPQAKGVGLGLMVGWALVSLVTVGICTGINPSLYAT
>NC_008705.1|WP_011561614.1|4537689_4539234_+|radical-SAM-protein
MGLRGDRLHRYVTAYCPHCHDEAPERPLADVERLSGRLVERDGRVWLERGCRSHGLVRTLYDEVPEILSYLEEWTAPTKVHTPDVPGNFDPIPQAYLRGLPEMQTQHTCILLQDISDTCNLRCPTCFTESSPDLRNVVPVAEVLANVDQRLRRENGRLDVVMLSGGEPTLHPRLAELLTELVDRPITRILVNTNGVRIATDDALLDLLTAHRERVEVYLQYDGLSEAAHRHHRGGDLRRIKRAALQRLSEREIFTTLVMTTALGVNDDEIGDMVRLALATPYVGGLTIQPQFGSGRSGDIDPQHRLTHTGVLSRLGPQTGGAVTWRDLTALPCSHPHCCSVGYLIRDDNDQWRSLVALIGYDNLKEKLGLVANRIADSEIPRQLRMAVQESLLGLLSEQSSLSHPQIGDIWQIICQSCDLGMSTLLTLASSALPGRRRKVRRLLGERVVRITVKPFMDMSTMIEERLVQCCVHVGTRSAQDQCAPFCAVQAWPALARQRLSATAGAALPIVAVR
>NC_008705.1|WP_041309833.1|4539230_4540169_-|Ppx/GppA-family-phosphatase
MVRVAAVDCGTNSIRLLIADAADGRLTDVHREMRIVRLGQGVDATGEFAPDALARTQGALAAYAELMRAYEVAKVRMVATSAARDVANRDAFFQMTADVLGEVVDGAVAEVITGTEEAELSFRGAVAELDPADGPFVVVDLGGGSTEVVVGRDRVDASFSADIGCVRLTERCLHSDPPTAEEVSAAREFIRGALDEALQQVPVQGARTWVGVAGTMTTLAALAHRMTTYDSEAIHLSRVGFRSLLEVCDELIAMTRQQRAALGPMHEGRVDVIGGGAIIVEELARELGERAGINELVVSEHDILDGIALSIA
>NC_008705.1|WP_011561616.1|4540161_4540662_-|DUF501-domain-containing-protein
MVERSDLDAVARQLGREPRGVLEIAYRCPNGEPGVVKTAPRLPDGTPFPTLYYLTHPVLTAAASRLESSGLMREMTERLSEDPELADAYRRAHESFLAERDAIEPLGTTFSGGGMPDRVKCLHVVIAHSLAKGPGVNPFGDEALAILAAEPGMQGILDADVWRLRG

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Crispr_ID: NC_008705_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008705_3

4642613-4642699

Orphan

Consensus_repeat	Method
GCATCATCCGCCGTCACCCGACCGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008705_3

>merge|NC_008705|3|4642613-4642699|CRISPRCasFinder
GCATCATCCGCCGTCACCCGACCGGCGCCCAGCCCGTCGTGCCGAGCGCCCAACAGACCGGCATCATCCGCCGTCACCCGACCGGCG

>NC_008705|3|3|4642613-4642699|CRISPRCasFinder
GCATCATCCGCCGTCACCCGACCGGCG	CCCAGCCCGTCGTGCCGAGCGCCCAACAGACCG
GCATCATCCGCCGTCACCCGACCGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008705.1\|WP_011768366.1\|4648299_4649748_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143421
NC_008705.1\|WP_011561709.1\|4645745_4646042_+\|chorismate-mutase	unknown	unknown	gnl\|CDD\|236117
NC_008705.1\|WP_011561704.1\|4639126_4640029_-\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
NC_008705.1\|WP_011561698.1\|4632142_4632772_-\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|235544
NC_008705.1\|WP_011561706.1\|4641465_4642548_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NC_008705.1\|WP_011768365.1\|4635300_4636431_-\|dimethyl-sulfone-monooxygenase-SfnG	unknown	unknown	gnl\|CDD\|274923
NC_008705.1\|WP_011561713.1\|4651513_4652263_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181324
NC_008705.1\|WP_011561715.1\|4653216_4653606_-\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|224861
NC_008705.1\|WP_011561699.1\|4632791_4634210_-\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011561710.1\|4646094_4648140_-\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224748
NC_008705.1\|WP_011561716.1\|4653624_4654389_-\|precorrin-6A-synthase-(deacetylating)	unknown	unknown	gnl\|CDD\|236218
NC_008705.1\|WP_011561717.1\|4654416_4655469_-\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NC_008705.1\|WP_011561705.1\|4640039_4641203_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NC_008705.1\|WP_011561702.1\|4636531_4637380_+\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NC_008705.1\|WP_011561700.1\|4634267_4635155_-\|DUF5336-domain-containing-protein	unknown	unknown	gnl\|CDD\|375092
NC_008705.1\|WP_011561697.1\|4630562_4632146_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NC_008705.1\|WP_011561703.1\|4637451_4638981_-\|acetyl-CoA-acetyltransferase	unknown	unknown	gnl\|CDD\|236204
NC_008705.1\|WP_011561708.1\|4643189_4645547_-\|DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|273429
NC_008705.1\|WP_011561714.1\|4652336_4653200_-\|Fpg/Nei-family-DNA-glycosylase	unknown	unknown	gnl\|CDD\|223344
NC_008705.1\|WP_011561712.1\|4649799_4651464_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234679

Protein	Function_ID	Function_description	E-value
NC_008705.1\|WP_011768366.1\|4648299_4649748_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	gnl\|CDD\|143421	cd07103, ALDH_F5_SSADH_GabD, Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like. Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.	0
NC_008705.1\|WP_011561709.1\|4645745_4646042_+\|chorismate-mutase	gnl\|CDD\|236117	PRK07857, PRK07857, chorismate mutase.	2.81797e-39
NC_008705.1\|WP_011561704.1\|4639126_4640029_-\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
NC_008705.1\|WP_011561698.1\|4632142_4632772_-\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|235544	PRK05647, purN, phosphoribosylglycinamide formyltransferase; Reviewed.	6.28927e-104
NC_008705.1\|WP_011561706.1\|4641465_4642548_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.79122e-42
NC_008705.1\|WP_011768365.1\|4635300_4636431_-\|dimethyl-sulfone-monooxygenase-SfnG	gnl\|CDD\|274923	TIGR04021, LLM_DMSO2_sfnG, dimethyl sulfone monooxygenase SfnG. This family of FMNH2-dependent members of the luciferase-like monooxygenase (LLM) family includes SfnG, a monooxygenase that converts dimethylsulphone (DMSO2) to methanesulphonate. This step can be followed immediately by methanesulfonate sulfonatase (an alkanesulfonate monooxygenase - see TIGR03565) for the FMNH2-dependent conversion an inorganic form. [Central intermediary metabolism, Sulfur metabolism].	0
NC_008705.1\|WP_011561713.1\|4651513_4652263_-\|SDR-family-oxidoreductase	gnl\|CDD\|181324	PRK08251, PRK08251, SDR family oxidoreductase.	4.84705e-163
NC_008705.1\|WP_011561715.1\|4653216_4653606_-\|phage-holin-family-protein	gnl\|CDD\|224861	COG1950, COG1950, Predicted membrane protein [Function unknown].	7.41776e-26
NC_008705.1\|WP_011561717.1\|4654416_4655469_-\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	1.22002e-68
NC_008705.1\|WP_011561710.1\|4646094_4648140_-\|acyltransferase-family-protein	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	3.61581e-67
NC_008705.1\|WP_011561716.1\|4653624_4654389_-\|precorrin-6A-synthase-(deacetylating)	gnl\|CDD\|236218	PRK08284, PRK08284, precorrin 6A synthase; Provisional.	5.61835e-142
NC_008705.1\|WP_011561705.1\|4640039_4641203_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NC_008705.1\|WP_011561702.1\|4636531_4637380_+\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	7.95963e-89
NC_008705.1\|WP_011561700.1\|4634267_4635155_-\|DUF5336-domain-containing-protein	gnl\|CDD\|375092	pfam17270, DUF5336, Family of unknown function (DUF5336). This Actinobacterial family of proteins has no known function. Most of the family members are predicted to have have 4 trans-membrane regions.	4.73071e-59
NC_008705.1\|WP_011561697.1\|4630562_4632146_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NC_008705.1\|WP_011561703.1\|4637451_4638981_-\|acetyl-CoA-acetyltransferase	gnl\|CDD\|236204	PRK08257, PRK08257, acetyl-CoA acetyltransferase; Validated.	0
NC_008705.1\|WP_011561708.1\|4643189_4645547_-\|DNA-helicase-PcrA	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_008705.1\|WP_011561714.1\|4652336_4653200_-\|Fpg/Nei-family-DNA-glycosylase	gnl\|CDD\|223344	COG0266, Nei, Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair].	7.29499e-67
NC_008705.1\|WP_011561712.1\|4649799_4651464_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0

>NC_008705.1|WP_011561706.1|4641465_4642548_+|M23-family-metallopeptidase
MAAHRSSRSREGASTNARQRQGVSIPAERPAEVTDIIPFNEFGDLDDIDFRDSTAFDRDSQIIRAPELDDLHDTDDLIPLRLAIPAQFRAEGDPDTPRRSRAYRESHTDVSDGAAATDIIDLRGRRAAHRKEAEGPIKSRLVIAAMAAGATAAGAYSMTQNTAPATTDTVLASGETTVEGASITGSVDGMQIVSVASTANTAVHHEEIQKAAAFAQERAEREARQMRPLYVMPTKGVWTSGFGYRWGVLHGGIDIAGPIGTPILAAADGVVIDVGPTAGYGAWVKLRHADGTVTLYGHLNTWSVSMGEQVMAGDQIATMGNRGNSTGPHLHFEVMVGGSNRIDPVGWLSKRGISTGSYVG
>NC_008705.1|WP_011561705.1|4640039_4641203_-|ADP-forming-succinate--CoA-ligase-subunit-beta
MDLFEYQAKELFAKHNVPTTPGRVTDTAEDAKAIAEEIGKPVMVKAQVKVGGRGKAGGVKYAATADDAFTHAQNILGLDIKGHVVKKLLVAEASDIAEEYYISFLLDRANRTYLAMCSVEGGVEIEEVAATKPDRLARIPVDATKGVDEAFAREIAEKGHLPAEVLDAAAVTIAKLWEVFVGEDATLVEVNPLVRTPDDQILALDGKVTLDANADFRHPEHAEFEDRDATDPLELKAKENDLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGEKHNGVKPANFLDIGGGASAEVMANGLDVILNDSQVKSVFVNVFGGITACDAVANGIVKALEILGEEANKPLVVRLDGNRVEEGRKILADANHPLVVLAQTMDEGADKAAELANK
>NC_008705.1|WP_011561704.1|4639126_4640029_-|succinate--CoA-ligase-subunit-alpha
MSIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQLVGGVNARKAGTTVSHVDKDGKDVELPVFGSVGDAMKETGADVSVVFVPPKFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNVEKGQKTRIIGPNCPGIITPGEALAGITPANITGSGPVGLVSKSGTLTYQMMYELRDFGFSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKVIVMIGEIGGDAEERAADYIKDNVSKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAAGVKVGKTPSETAQLAREILQNQ
>NC_008705.1|WP_011561703.1|4637451_4638981_-|acetyl-CoA-acetyltransferase
MVDPRTPVIVGVGQFTERIDDDGYRGLSAVDLATEATRAALSDTGADTAAVAQAIEVFAGLRQFEICTPFADPPLGASDNYLRSVAKRVGADPARAVLEPIGGNGPQKLMTEFAGAIAAGDIEVALVVGSEPGSTAKYFAKRDRKPDFTEHVGGQLEDRGYGFEQYMSDYTVAHGLTGAPVQYGLLDNARRAAKGLGVAEYRREMAELFAPFSAVAAKNPYSSSPVERSVDEIVTVTDENRMICDPYPRLLVARDTVNQGAAAIVMSVAAARRLGVPEGKWVYLRGHADQTEQDLLDRERLGVSVSAKQAVAEALRVAGIGIDDVATFDLYSCFPFPVFAVCDEFGLDADDPRGLTLTGGLPYFGGPGNSYSLHGIAETVAAMRDNPGSYGLVGANGGVMSKYSVGVYSTEPADWAADRSKELQADIAGLPKVPVTRHADGRGTVETYSVRYDWPVRTGIIIGRLDADGSRFLAISEDDDLVALMSDGDPLGAAIEVRPDGDKNRATSA
>NC_008705.1|WP_011561702.1|4636531_4637380_+|LLM-class-F420-dependent-oxidoreductase
MDFGLVLFTSDRGIAPATAAKLADDHGFRTFYVPEHTHIPIKREAAHPTTGDETLPDDRYMRTLDPWVSLGTACAVTSRVRLSTAVALPVEHDPITLAKSIATLDHLSGGRVSLGVGFGWNTDELADHNVPPGRRRTMLREYLEAMRALWTQEEASYEGEFVNFGPSWAWPKPVQAHIPVLVGAAGTEKNFKWIAKSADGWITTPRDFDIDAPVKLLQDTWAGAGRDGAPQIVALDFKPDPDKLARWRELGVTEVLFGLPDKSEAEVAAYVERLAGKLSALV
>NC_008705.1|WP_011768365.1|4635300_4636431_-|dimethyl-sulfone-monooxygenase-SfnG
MSTERIADHVKFAYWVPNVSGGLVTSTIEQRTDWNYEYNKKLAQTAENNGFEYALSQVRYEASYGAEYQHESTSFSLALLLATERLKVIAAVHPGLWQPAVLAKLGATADQLSGGRFAVNVVSGWFKDEFTHLGEPWLEHDERYRRSAEFLQVLRKIWTEDDVDFRGDFYRIHDFTLKPKPVNTPERPNPELFQGGNSTAARRNGGRYADWYFSNGKDFDGITEQIVEVRDHAREVGREVKVGLNGFIIARDTEKEARDTLREIIEKADKPAVEGFRSAVQQAGNSTADKKGMWADSSFEDLVQYNDGFRTQLIGTPEQIAERIAAYRKRGVDLILGGFLHFQEEIEYFGARVLPLVREIEASDASSADAPALATV
>NC_008705.1|WP_011561700.1|4634267_4635155_-|DUF5336-domain-containing-protein
MTYSPGSPGYPPANQPTTQFSAPTQHFGKVPEQPAAGEGPNKLPAYLLMVVAALGLLVYLCNFGPIFEVSASDFLGQGGTVSGSTLGIGLAVISALTAGLLAGVTLLSKGRTYVAIAAVLSVLALLLVIAELINKPSEASIGWALYALIVLSLLQAGSAVAALLFDTGVLTPPTPRPKYDQQQQYGQYGGPGPYYGQPHSGAHQPQQLHTGSHQQAPQQQRPGYPSQYGGGYPGAGGPSTGGFQSSGQQSGPPTPPTGFPTYGQPQQQQGGGSGQGGSGQGQQPPTSQQSGQNPS
>NC_008705.1|WP_011561699.1|4632791_4634210_-|hypothetical-protein
MDNRPVGTRQARELLRVAFGPSVVALVVIAAVTLLQLLIANSDMTGAFGAIASMWLGVHLVPVSIGGSELGAMPLMPALMMVWGTARTTAAATPPHGSWFVTRWVVASALGGPLLIAAIALAVIHDAASVLTELQTPSALRAFGGVLVVHLIGAAIGVASRVGRRTVLTSPLPNWLPDAFRAAAAGVLALAGLCGVVIAGSLVVHWSTMHELFAITDSVFGQFSLTVLSLLYLPNVVVGAAAVAVGSSAHIGLATFSSFTVLGGDVPALPVLAAVPEPPLGPVWVALLIVGAAAAVAVGQQVARRPAPIHIAAAKLVVASAVAALTMALLGEAGGGRLGNFGQVGVDQTTFGPGVFLWFTVIGGLTVVMSGGIVRRPRRVRVTEPEPEPEPEAAPEQDLDDAETGPIVDPVAAAPEPVTAEPVAEPVPGEPDPALDPEEHFIVDDAGSPPNDSAPNDSPPNDSAPTDGEPRR
>NC_008705.1|WP_011561698.1|4632142_4632772_-|phosphoribosylglycinamide-formyltransferase
MQQPLRVPPSAPARLVVLASGTGSLLASLLESTVDDYPARVVAVGTDRTCAALDIAAAAQVPTYTVRLGEYPDRTAWDAAVTAATAEHEPDLVVSAGFMKILGPEFLNRFPGRVVNTHPALLPAFPGAHAVADSLAYGVRVTGCTVHLVDAGMDTGPILAQEAVAVRDGDDEATLHERIKVVERRLLVDVLAAMAQRGVTWTGRKATIG
>NC_008705.1|WP_011561697.1|4630562_4632146_-|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MSGDQGQAGAKRPIRRALISVYDKTGLIDLARGLHEAGVDIVSTGSTAKTIADKGIPVTPVEFVTGFPEVLDGRVKTLHPHIHAGLLADTRKPEHVEALAKLGIAPFDLVVVNLYPFSETVESGASVDECVEQIDIGGPSMVRAAAKNHPSVAVVVEPNGYDGVLAAVRTGGFTLAERKILASLAFRHTAEYDVAVASWMGSTLAPEEPAQKLPAWVGGTWRRAAVLRYGENPHQQAALYRDATAWPGLAQAEQLHGKEMSYNNYTDADAAWRAAFDHEEICVAIIKHANPCGIAISSVSVADAHRKAHECDPLSAFGGVIATNSSVSVEMAETVADIFTEVIVAPAYEPGAVEILSRKKNIRILVAAQPPTTGTELRPISGGLLLQQRDALDADGDDPVNWTLATGEPADPATLANLKFAWRSCRAVKSNAIVVVADGATVGVGMGQVNRVDAARLAVQRAGDRVRGAVAASDAFFPFPDGLETLTEAGVKAIVHPGGSMRDDVVTEAAAKAGISLYLTGARHFAH
>NC_008705.1|WP_011561708.1|4643189_4645547_-|DNA-helicase-PcrA
MSVNVTEPSSRPDDRAEELLDGLNPQQRQAVLHEGSPLLIVAGAGSGKTAVLTRRIAYLLAARDVGVGQVLAITFTNKAAAEMRERVVHLVGPRARSMWVATFHSTCVRILRNQASLLPGLNSNFSIYDADDSRRLLLMIGKDMGLDTKKYSPRLLSNGISNLKNELIGPEQAAAEASEAADDLARIIADVYAEYQRRLRAANALDFDDLIGETVAVLQRFPQIAQYYRRRFRHILVDEYQDTNHAQYVLVRELVGGGAHDTGEVAPAELCVVGDADQSIYAFRGATIRNIEDFERDYPNATTILLEQNYRSTQTILNAANSVIARNAGRREKRLWTDSGHGELIVGYVADNEHDEARFVAQEIDRLADDGHSYNDFAVFYRTNNNSRALEEVFIRAGIPYKVVGGVRFYERREIRDIVAYLRVLDNPGDSVSMRRILNTPRRGIGDRAEACVAVYAENTGASFNDALQAAAEGKVPMLNTRSEKCIASFVQMLDDLRGRLGDELGELVEAVLDRTGYRAELEASNDPQDLARLDNLNELVSVAHEFSIDRANAAALAEDLDEPVDEDIPDTGVLAQFLERVSLVADADDIPEHGSGVVTMMTLHTAKGLEFPVVFVTGWEDGMFPHMRALGDPNELSEERRLAYVGITRARQRLYLSRAKVRSSWGQPMLNPESRFLREIPQELIDWRRTDPENRRPSFSAPSRMSSGSSGTSFGAPRPSPMRSGGGKKPLIVLEPGDRINHDKYGLGRVEEVSGVGESAMSLIDFGSAGRVKLMHNHAPVQKL
>NC_008705.1|WP_011561709.1|4645745_4646042_+|chorismate-mutase
MRPEPPHEESEMSIETDQSLDIDALRQEIDELDAAILAAVQRRTEVSKIIGRARMASGGTRLVHSREMKVIERYSVLGPEGKDLAMLLLRLGRGRLGH
>NC_008705.1|WP_011561710.1|4646094_4648140_-|acyltransferase-family-protein
MTAVTAAPVRVVARRRWVAPVAGRTRRGTAGRREIPALDGIRAVAVALVLADHGGVPGVSGGFLGVDVFFVLSGFLITSLLLDELGRTGRVDLRGFWIRRARRLLPALLAMVAAVVAARVFFPPDAVTTLRDDAVAAFFWVANWAFVAQHTDYFSQGSPPSPLQHTWSLGVEEQFYLVWPLLLIAVVGVLAIRRSAPTLRAVRWGAFGLAVVGGAASAAAAVLLTSEASANRVYFGTDTRVQALLIGAAAAALLVRDWSTVTMGTPIRARWGRWVARVLSVVGLAGLAVLAHHATGAPAEYRMGLFTAAAAAAVLVVATAALDQAGPVARLLALRPLVWLGTISYGVYLWHWPIFLFLNGERTGWTGWRLLIARCAATLAVAVLSYWLLERPIRRWRPATVPQLPLALATAATAAVVTISVVPVGVQPGDDLPPGGLLDINSAAAVLPERPIPVGAVGAQRPPGTRSVAVFGDSVAWTLMRYLPETPGLHFSNYTTIGCGIARGGPYKTTGQTLTQKPECETWPTRWAQRIGHDRPDVVLLMVGRWELVDRINEGKWTHVGDDAYDGYLRGELDRALDILGSTGARVVVTTAPYNRRAEQADGTLYPEDDPDRADAWNELLREATAKRPNVTVLDLNKKLSPRGYYTNRVEGIQMRDDGVHPTKEAVEWLTPWLTEALSKK
>NC_008705.1|WP_011768366.1|4648299_4649748_-|NAD-dependent-succinate-semialdehyde-dehydrogenase
MDTTALLKSVPTGLWIGGEEREAKSTFNVLDPSSDEVLVAVGDATAEDAVAALDAACAVQAEWAATPARKRGEILRSVFETLTDRADDIAALMTLEMGKVLAESKGEVTYGAEFFRWFAEEAVRIGGRYTPSPAGTGRIIVTKQPVGPCYAITPWNFPLAMGTRKMGPAFAAGCTMIVKPAQETPLTMLYLAKLMAEAGLPKGVLSVLPTSSPGPVTEALVDDGRLRKLTFTGSTGVGKSLVKQSADKLLRTSMELGGNAPFIVFDDADVDAAVDGAMLAKMRNGGEACTAANRFHVANSVREEFTEKLVKRMSEVTLGNGLDESATLGPLINNKQLQKVTELVSDAVSRGATVAVGGVAPGGPGNFYPATVLADVPADARILKEEVFGPVAPITGFDSEEEGVAAANDTEYGLAAYVYTRSLDRALRVAEAIESGMVGINRGVISDAAAPFGGIKESGFGREGGTEGIEEYLDTKYIALTK
>NC_008705.1|WP_011561712.1|4649799_4651464_+|glucose-6-phosphate-isomerase
MTADDQLTDISATSAWQALQRHHGEIAGRHLRELFAEDPSRGTELTVSVGDLYIDYSKHRVTRETLRLLVDLARAAGLEKRRDAMLSGVHINTSEDRAVLHTALRLPRDASLTVDGQDVVADVHEVLDRMGDFTDRLRSGEWTGATGERIRTVVNIGIGGSDLGPAMVYESLRHYADAGISARFVSNVDPADLVAKLDGLDPATTLFIVASKTFSTLETLTNATAARRWLTNTLGDAAVARHFVAVSTNQKLVDEFGIDTANMFGFWDWVGGRYSVDSAIGLSVMAAIGRERFAEFLAGFHLVDEHFRTAPLEANAPALLGLIGLWYSNFFGAQSRAVLPYSNDLSRFAAYLQQLTMESNGKSVRADGTPVSTDTGEIFWGEPGTNGQHAFYQLLHQGTRLVPADFIGFSQPTDDLPTADGTGSMHDLLMSNFFAQTQVLAFGKTAEEIAAEDTPADVVPHKVMPGNRPTTSILATKLTPSVVGQLIALYEHQVFTEGVVWGVDSFDQWGVELGKTQAKALLPVITADDSPAEQSDTSTDALVRRYRAERGRSA
>NC_008705.1|WP_011561713.1|4651513_4652263_-|SDR-family-oxidoreductase
MTRQRILITGASSGLGAGMARAFAAKGRDLALCARRVDRLDELKAELKQRYPEITVAVAELDVNDHDQVPKVFAALSDELGGLDRVIVNAGLGKGAPLGSGKLWANKATIETNLVAALVQIETALEMFKRTGAGHLVLISSVLGNKGVPGVKAAYAASKAGVSSLGESLRAEYAKGPIRVTVLEPGYIESEMTSKSASTMLMTDTDTGVAAMVRVIEKEAGRAAVPWWPWAPLVQLMRVLPPRLTRLFA
>NC_008705.1|WP_011561714.1|4652336_4653200_-|Fpg/Nei-family-DNA-glycosylase
MPELPEVEALADHLRRHAVGLPIGRVDVSAFSVLKTFDPPITALHGREVTDAHRWGKYLGLQAGDLYLITHLSRAGWLRWSDKLAAAPLKPGKGPIALRVHLGTPGAAPGFDLTEAGTQKRLAVWLVSDPSAVPGIAALGPDALELTADELGVLLSKQSGRIKTVITDQKVLAGIGNAYSDEILHVAQLSPFATANKLTPEQVATLHDAMLSVLTDAVSRSVGQQAATLKGEKRSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGRVLADRRLSRLLK
>NC_008705.1|WP_011561715.1|4653216_4653606_-|phage-holin-family-protein
MGFLLRAAVTGVALWLVTQFVSGMEFVGGENTLQRVGIIFVVAVVFGLVNAIVKPIVQILSIPLYVVTLGLFHVVVNALMLWLTAWITEHTTHWGLYIDDFWWTAVWAGIVLSIVSWVLSVLSGNLIKR
>NC_008705.1|WP_011561716.1|4653624_4654389_-|precorrin-6A-synthase-(deacetylating)
MTRRIHVIGIGAGDPDYVTAQAVAALNDTDVFFAMDKGSRTRGGQQADTKDDLVALRRLICERFITEPGYRFVEMPDPVRAKSGDYRQAVDEWHAARARLWAEAIERELDDDGVGAFLAWGDPSLYDSTLRILDRVAAHVDIDYDVIPGVTAIQALTARHRIPLNDVGEPVLITTGRRLREQGLTGTAVVMLDADCAFTGTPAQTRIWWGAYLGTADELLVSGTVGEVGERIVALRAEARERHGWIMDTYLLRP
>NC_008705.1|WP_011561717.1|4654416_4655469_-|YihY/virulence-factor-BrkB-family-protein
MAEAASTKHRAPDPDDPRKPESPTDLTKPSAFYVLRKTAREFGHDQCTDLAAALTYYAVLSLFPAVLVMVSLLGVFGQGRRTTDALLDIVSDVAPASTVDTLRPTIEQLVESPSAGFALVIGILTALWSASGYVGAFGRAMNRIYEVAEGRPVWKLRPLQLVLTFAALLGAALVAFMLAVSGPVAEALGNAIGLGEAAVTAWSIGRWPVILLLVVVAVAVLYYATPNVQQPKFRWISLGAGLAILTWIVASVGFGFYVANFSSYNKTYGTLAGVIIFLLWLWITNLALLFGAELDAELERGRQLQAGLPAERELQLPPRDTRVIEKKEAAIEEDVERAKALRRSRGRDDG

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Crispr_ID: NC_008705_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008705_4

5574610-5574710

Orphan

Consensus_repeat	Method
GGCCACGACGGCGGGGCCGACGGCACCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008705_4

>merge|NC_008705|4|5574610-5574710|CRISPRCasFinder
GGCCACGACGGCGGGGCCGACGGCACCGCTGACGCGGGCGAGGGAACCGCCGACGGCGGTTCGAACCCCGAAGGCCACGACGGCGGAGCCGACGGCACCGC

>NC_008705|4|4|5574610-5574710|CRISPRCasFinder
GGCCACGACGGCGGGGCCGACGGCACCGC	TGACGCGGGCGAGGGAACCGCCGACGGCGGTTCGAACCCCGAA
GGCCACGACGGCGGAGCCGACGGCACCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008705.1\|WP_011562624.1\|5576861_5577344_-\|DUF302-domain-containing-protein	unknown	unknown	gnl\|CDD\|269820
NC_008705.1\|WP_011768420.1\|5565495_5567622_-\|5-oxoprolinase	unknown	unknown	gnl\|CDD\|376810
NC_008705.1\|WP_011562619.1\|5572330_5573299_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187539
NC_008705.1\|WP_011562628.1\|5579680_5581057_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340925
NC_008705.1\|WP_011562625.1\|5577356_5577887_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NC_008705.1\|WP_011562618.1\|5571835_5572327_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NC_008705.1\|WP_011562617.1\|5570468_5571746_-\|multidrug-effflux-MFS-transporter	unknown	unknown	gnl\|CDD\|340878
NC_008705.1\|WP_163647433.1\|5565317_5565482_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011562623.1\|5575934_5576822_+\|sucrase-ferredoxin	unknown	unknown	gnl\|CDD\|227101
NC_008705.1\|WP_011562631.1\|5582789_5583140_+\|hypothetical-protein	unknown	unknown	unknown
NC_008705.1\|WP_011562622.1\|5574723_5575938_+\|cupin	unknown	unknown	gnl\|CDD\|369647
NC_008705.1\|WP_011562616.1\|5569915_5570503_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_008705.1\|WP_011562627.1\|5579087_5579678_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_008705.1\|WP_120313196.1\|5564413_5565040_-\|GAF-and-ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|198080
NC_008705.1\|WP_011562629.1\|5581219_5582059_+\|nitrile-hydratase-subunit-beta	unknown	unknown	gnl\|CDD\|376740
NC_008705.1\|WP_011562612.1\|5563648_5564398_-\|GAF-and-ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|379056
NC_008705.1\|WP_011562630.1\|5582077_5582785_+\|thiocyanate-hydrolase-subunit-gamma	unknown	unknown	gnl\|CDD\|188402
NC_008705.1\|WP_011562621.1\|5573910_5574429_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|366361
NC_008705.1\|WP_011562626.1\|5577889_5578852_-\|NmrA-family-NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|187542
NC_008705.1\|WP_011562620.1\|5573361_5573817_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670

Protein	Function_ID	Function_description	E-value
NC_008705.1\|WP_011562624.1\|5576861_5577344_-\|DUF302-domain-containing-protein	gnl\|CDD\|269820	cd14797, DUF302, Uncharacterized domain family DUF302. These domains are mostly found in bacterial single-domain proteins and have been shown to form homodimers; they may also bind zinc. Also characterized as COG3439.	2.02908e-05
NC_008705.1\|WP_011768420.1\|5565495_5567622_-\|5-oxoprolinase	gnl\|CDD\|376810	pfam02538, Hydantoinase_B, Hydantoinase B/oxoprolinase. This family includes N-methylhydaintoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase EC:3.5.2.9 which catalyzes the formation of L-glutamate from 5-oxo-L-proline. These enzymes are part of the oxoprolinase family and are related to pfam01968.	8.33943e-146
NC_008705.1\|WP_011562619.1\|5572330_5573299_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187539	cd05228, AR_FR_like_1_SDR_e, uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs. This subgroup contains proteins of unknown function related to aldehyde reductase and flavonoid reductase of the extended SDR-type. Aldehyde reductase I (aka carbonyl reductase) is an NADP-binding SDR; it has an NADP-binding motif consensus that is slightly different from the canonical SDR form and lacks the Asn of the extended SDR active site tetrad. Aldehyde reductase I catalyzes the NADP-dependent reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. The related flavonoid reductases act in the NADP-dependent reduction of flavonoids, ketone-containing plant secondary metabolites. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.12142e-45
NC_008705.1\|WP_011562628.1\|5579680_5581057_-\|MFS-transporter	gnl\|CDD\|340925	cd17367, MFS_KgtP, Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters. This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.59775e-173
NC_008705.1\|WP_011562625.1\|5577356_5577887_-\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	7.56492e-32
NC_008705.1\|WP_011562618.1\|5571835_5572327_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	7.04348e-10
NC_008705.1\|WP_011562617.1\|5570468_5571746_-\|multidrug-effflux-MFS-transporter	gnl\|CDD\|340878	cd17320, MFS_MdfA_MDR_like, Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.89162e-92
NC_008705.1\|WP_011562623.1\|5575934_5576822_+\|sucrase-ferredoxin	gnl\|CDD\|227101	COG4759, COG4759, Uncharacterized protein conserved in bacteria containing thioredoxin-like domain [Posttranslational modification, protein turnover, chaperones].	1.07244e-24
NC_008705.1\|WP_011562622.1\|5574723_5575938_+\|cupin	gnl\|CDD\|369647	pfam08007, Cupin_4, Cupin superfamily protein. This family contains many hypothetical proteins that belong to the cupin superfamily.	1.13072e-36
NC_008705.1\|WP_011562616.1\|5569915_5570503_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.06619e-13
NC_008705.1\|WP_011562627.1\|5579087_5579678_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.4469e-12
NC_008705.1\|WP_120313196.1\|5564413_5565040_-\|GAF-and-ANTAR-domain-containing-protein	gnl\|CDD\|198080	smart01012, ANTAR, ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	3.4415e-09
NC_008705.1\|WP_011562629.1\|5581219_5582059_+\|nitrile-hydratase-subunit-beta	gnl\|CDD\|376740	pfam02211, NHase_beta, Nitrile hydratase beta subunit. Nitrile hydratases EC:4.2.1.84 are unusual metalloenzymes that catalyze the hydration of nitriles to their corresponding amides. They are used as biocatalysts in acrylamide production, one of the few commercial scale bioprocesses, as well as in environmental remediation for the removal of nitriles from waste streams. Nitrile hydratases are composed of two subunits, alpha and beta, and they contain one iron atom per alpha beta unit.	1.21835e-71
NC_008705.1\|WP_011562612.1\|5563648_5564398_-\|GAF-and-ANTAR-domain-containing-protein	gnl\|CDD\|379056	pfam13185, GAF_2, GAF domain.	2.43975e-11
NC_008705.1\|WP_011562630.1\|5582077_5582785_+\|thiocyanate-hydrolase-subunit-gamma	gnl\|CDD\|188402	TIGR03887, Thiocyanate_hydrolase_subunit_gamma, thiocyanate hydrolase, gamma subunit. Members of this family are the gamma subunit of thiocyanate hydrolase. This family is closely related to the nitrile hydratase, alpha subunit (TIGR01323).	9.91496e-136
NC_008705.1\|WP_011562621.1\|5573910_5574429_+\|VOC-family-protein	gnl\|CDD\|366361	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	2.7476e-16
NC_008705.1\|WP_011562626.1\|5577889_5578852_-\|NmrA-family-NAD(P)-binding-protein	gnl\|CDD\|187542	cd05231, NmrA_TMR_like_1_SDR_a, NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs. Atypical SDRs related to NMRa, TMR, and HSCARG (an NADPH sensor). This subgroup resembles the SDRs and has a partially conserved characteristic [ST]GXXGXXG NAD-binding motif, but lacks the conserved active site residues. NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. HSCARG has been identified as a putative NADP-sensing molecule, and redistributes and restructures in response to NADPH/NADP ratios. Like NmrA, it lacks most of the active site residues of the SDR family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Atypical SDRs are distinct from classical SDRs. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.13689e-79
NC_008705.1\|WP_011562620.1\|5573361_5573817_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.10488e-20

>NC_008705.1|WP_011562621.1|5573910_5574429_+|VOC-family-protein
MHLRRVNHVVLSVSDLDRSLTFYRDLLGLLPVAELPGSEHWPAMVFLRSPAPSSNHHDLALIANAEAPAPTSAPRPAGMFHVALEVGTLDELAAVQQTLDSAGVLRGAVDQGMHLSVYTADPDGIEVEIIWRAPDDAWSYDDALTRRPLDVASARERWGGHLATGSAAGAPA
>NC_008705.1|WP_011562620.1|5573361_5573817_-|MarR-family-transcriptional-regulator
MAERAERSGVPTPAELSDDFFAAAKALRAHANATLREQGFTLARGKLLSILQRNGATRVSVLARKLDITTRSVTEAVDALERDGLVRRAPDPADRRAVLVSLTDRGSAVIDAAVQPRRAAMKRTFGALSPSQRTELAELLAILTASTRDPG
>NC_008705.1|WP_011562619.1|5572330_5573299_-|NAD-dependent-epimerase/dehydratase-family-protein
MLIGVTGGTGYVGAHCVRALLADGHRVRLLVGPDAEGAPVLEHLAELGDVDVFSGDIRDAMTIDLLLDGCDAVLHGAGVVGTDNRRAALMWEVNAYATEALLTQAVRAGLDPVISVSSYSSLFPPPDGIIGPDTPPANGRSAYAKTKGYADRVARRLQAEGAPVVVTYPSSVVGPAFHTAPGVTERGWAPIVRFGVAPRLRGGMQMIDVRDVAAVHAAAMKPGRGPRRYVCGGELITFDGMIDALERGSGRRFRRIPVSQAVFRGMSRIGDTLAGIVPLGDGLSYEAALLLTAATPTDDSATLADFGLTWRSPTDAIIASFA
>NC_008705.1|WP_011562618.1|5571835_5572327_+|winged-helix-turn-helix-transcriptional-regulator
MPVVTEPTDQYRDLALVLHDLSWRLARFGPAQVGLEPLPASELAVLRAVMEAPGRSVSEVAAVTNMQSSNVSTAVRSLMERGLLDKHADPRDRRVSLLEPTARALTEREAIENAIARSVSTALTALPGADVEALVAAVPAIRALTTHVAAALTGRADLAQRGA
>NC_008705.1|WP_011562617.1|5570468_5571746_-|multidrug-effflux-MFS-transporter
MSQKIAAVASPPSAVLIAVLALLNAVTPFSIDMYLSAFPEMASEFGVSPSTIQLSLTTFLIGLAVGQLIIGTLSDRYGRRRPLIIGTVACVAVSVACAVAPSIALLIGLRFAQGFCGAAGVVISRAVIADRSRGSRAARLFAVMMLIGVLAPITAPILGGVIVTGFGWRAVFLALAVLNLATLLGVVLTVRESLSEEHRRPGGLKALGVSARTVLGNRHYLGYTLVMAFAAAAMFGYISASPFVVQNILGFSPAAYSVTFGSCALAVGAGSLISARLVRTVAPRRVLMGGVTALLVVATLMLLNVTAGHVIGWATIALMACFMGSIGFVYANATALALGEVPRAAGTGSAVLGFLQYGMGAITPPLVGLAGQSSAVPMGLVMFGAATLAALSMFVLTRGHVPFGDEDDDAGDAPVTVSAGGTTSR
>NC_008705.1|WP_011562616.1|5569915_5570503_+|TetR-family-transcriptional-regulator
MATLREAQKQRTRGLLLECGLESFASKGYQATTIDDIAAAAGTTRATFYLHFSSKAQLMRQLIDDVDAILTAADDPPLTEVVASGSRDLLREWLSRKFDQWPAIRPYMLVVHDAEFSEPEVAAVLDKWFDGTVEAMRAGLDAAGRFDAESRRPRCLLAFGQFEFVSRQWFRRGWQVEREVLLETLTDSWCHLLTQ
>NC_008705.1|WP_011768420.1|5565495_5567622_-|5-oxoprolinase
MNTLTDTPVDVDVITYEVVRNRLTAIVAQQSAVLKNVSGSPLVTEANDCNTGVYLAGGEVVAMGPHNLFHSGSMETVVNHIIADCTDTVGIEEGDVFITNDPYKGVLHMPDVTMIEPVFHEGVRIGWVGTCAHVLDIGGMTPSSWSPAAREVYQEGLILPPTKIISGGRTRHDVWNLILAASRLPANLGLDLKAMIAANNHARQGMLRLVDRYGADVVTTVMTTMLDRSEAQVRERLLAVPDGTTRARTYFDHDGHKSTLARVEVELRKDGDRLVFDYGRTAEQLPGFFNCTMSGLRGGVFSAILPVLAHDIPWNSGVMRAIEVTAPEGTIVNARHPAPCGASTTGATTIVESTAGSALSTLVSAHDELRGEARAVTTGGLMVFHIAGRNQYGEPYGGAMTEVLAGGAGANVNRNGVDYRGPNEILTGQFNNVEGEEAVFPLLYLNRSANTDGGGAGRHHGGVSVSSSFVLHDTDALHGVMAGHSMSMPNSLGLHGGLPGSTHQVTIVRGGEPVVYTGSPGEIHLAAGDVVDWSFHGGGGWGDPLDADPDEVLADVTAGRISTESASRLYGVVLTAGAVDREETTARRNRERARRRLWARHRVFGARQLDMVGDARRIGDRLVLTHDGVSAVYACDCGNVIAPADENWKDYAAHSRLSEHDLGPKVRLHPGLRADAYACAGCGTLLAVEIRAHEDEPLRDLELAGQSG
>NC_008705.1|WP_163647433.1|5565317_5565482_+|hypothetical-protein
MSPRRSIARLLAATERAASRAADGRWAVARLRRDREFTDRSRDNRLAHQRRVDK
>NC_008705.1|WP_120313196.1|5564413_5565040_-|GAF-and-ANTAR-domain-containing-protein
MMLLGIDAAAISLVFDGANTGTLGASGTLARSCDELQFTLGEGPCLDTVTHRAPVFVVDLADPDETRWPVYGPAMLDMRIRGVFAMPVLIAGEYVGALDLFRTEPGGLRAGQLAGAIAAAELAGIPLLDLLDTDLRAAVDEPGSDAWAELNALSRTEVSQATGMLVAQLGVDPPEALLRLRAHAYSTGRSASDVARDILERRLRLEAD
>NC_008705.1|WP_011562612.1|5563648_5564398_-|GAF-and-ANTAR-domain-containing-protein
MTDPSRETRVLDAVVTLVDSLLDDFDVVDLLTELTERCADLLDVAAAGFLLVDPMDRLRLLAATTDQAEALELFQLQSDEGPCVDCYRTGLPVSVADLTGAGQRWPRFVPAAREAGFASVHAVPMRAAGIVLGALGLFGSRPGALNEADLLVSQTLAHVACVAILQEHPPTPATVLPQLRSALTSRIVVEQAKGFLREIFDVPVEEAFTLLRTYARSRGEHLTDVARALMGDRLVRPVMIAALTEMVER
>NC_008705.1|WP_011562622.1|5574723_5575938_+|cupin
MLSRCIATDPHTFATEYWGRRPLLSRSGALPRDFADLLSPGMVDELIAERGVRAPFIRLAKEGDVLAKDCYLGPAGFGAEMPDQVDSAKVLTQFSAGATIVLQGLHRLWPPVIDLVRHLVDDLGHPVQANAYITPPSNRGFDPHYDVHDVFLLQTAGEKRWVVHEPVHPHPLPSQPWTQHRDAIAERAAGEPVIDTVLAPGDALYLPRGWVHSAHALDTTSIHLTIGVSAVTGVDVARAVVDALADSAAFRAPLPMGGDPADRDEIIAAVTKVMAQMVETMRDDATALSGAAADRLTRTHASRTRPVAVRPLATLDAAAHADTTTVQWRHGLVATADTAGDRIELRLTDRVLSFPASCAPAVLALQRGLAADAGSLPGLDRADGTVLIRRLLREAVVTPVPATA
>NC_008705.1|WP_011562623.1|5575934_5576822_+|sucrase-ferredoxin
MTLRKRAPCSDQSLLRRDPMYGTASAGSSWVLLELPGGWGPSAFLQSPAVIDPELGRAIVRRVEGAKMRIAAIRRHGRRTDTPRWRWFIARAVVGGEALYAGEVDNPRDYLDLALDGSDGTLSTDPVVAVCAHGRHDQCCAVRGRGAIAAIADAYPEMAWECSHLGGDRFAATMLILPEGLCYGRVDSTDAAELVRLYLDGRLDNRYLRGRTSLPHAVQAAQYFAREKYGDDRIAGLPTLSAEHTDHRHRVVLGGESGPVEVTVEEGWSEPLLSQCHAKVPGRVKIFSLVSITPA
>NC_008705.1|WP_011562624.1|5576861_5577344_-|DUF302-domain-containing-protein
MTEPTTVVDYVARRILVALPDAYDEARARYEQLVPIVDLEACSSAGSWAAVLAAVEVQAPNGFMRYYRGDVTSVVAGSPSRWKATQYLMGNHTIAETMFRHDPSVMVYAPLRTLIYEDPAGRTRPDAPGWPSTSPACSSPASVTPGSPRSASVSTLSCRG
>NC_008705.1|WP_011562625.1|5577356_5577887_-|PaaI-family-thioesterase
MTQDATLTARSGHWGAENTRTVSWHDPGPTTNEGLRMAGIDYLRAMLDGRLPPPPIANLLQMGLTAVEPGRVTFTCTPDQSTYNPIGAVHGGLVCTLLDSAAGCAMHSVLAAGRGYTSVEIKVNYLRGVRLDTGRLTATGTVIKAGARVGFTEATVTDDTGTLIASASSTLLIFDL
>NC_008705.1|WP_011562626.1|5577889_5578852_-|NmrA-family-NAD(P)-binding-protein
MTPTNPILVIGATGRHGNTGEHLVTRLREEGRAVRVLARTFGERTDRLADLGAEIVRGDLQDRGSLVAALADVDLAYFTYPIADGVVPAAANYASAVREVGRNPRTVVMSMGPANPNHPSDLGKGQWLAEQVMEWAGLDLLILRIAALFHENLLVLHAPSIRKDAVFRNSFGASVIGWISGRDAADLSVAALLHPQRFDGPVTYPRGSEQFTHADIAALLSEVLGTPVGFTPVCEAAWRDELLELADNDADGVVNPAMAQHISAVGAAISRSGAAIPADPATLRDLIGREPVSLREYLVANREAFEPIGVHTLVAAKAGE
>NC_008705.1|WP_011562627.1|5579087_5579678_+|helix-turn-helix-transcriptional-regulator
MLPPVTTAPAGRRGRGARERIIRAASALFYRRGIHATGVDLLTQEAQVSKRTFYQHFPSKVELVETYLREIAENGGSPAERRLDLPGLGPRERLLAIFDASAVKRFRGCPFHNAAVESAGALECVDEIVREHKRWFADRLAQVSTEAGARDPYLLGEQLLVLFEGATALSTSMGDTAPMVHARSAAAQLIDDACRV
>NC_008705.1|WP_011562628.1|5579680_5581057_-|MFS-transporter
MSDGETLSSSTGPTRAPTSTRRAVLNTIRGSAGNLVEWYDVYVYTVFATYFEAQFFDQDDENSTLYIYAIFAVTFVMRPVGSWFFGRFADRRGRKAALMVSITVMSSCSFVVAVMPTREVIGYWAAVILIAARLLQGFATGGEYGTSATYMSEAATPRRRGFLSSFQYVTLVGGHVLAQFTLLIALSVLDVEAVTAWGWRIGFFIGGIAALVVLWMRRSMDESLSDSHLEAIREGNDREAGSVKALFTTHWRALLLCFLITAGGTVAFYTYTINAPAIVKSTFGSDRALTGTWINLLGLIFLMLLQPLGGLLSDKVGRKPLLISFAVGGILYTYVLLTYLPQTTSPLTAFALTAVGYIILTGYTSVNAIVKAELFPADVRALGVGLGYALANSAFGGTAPLLYQGAKSSDQIGWFIVYVTVVIGVSLSVYVFGLKNKGITALDREQGSAWRVPEPAAR
>NC_008705.1|WP_011562629.1|5581219_5582059_+|nitrile-hydratase-subunit-beta
MSTAADRAAQLNLVARLKSAYPELPDAPTPDLLDHGRITAYLKPVHDVGGEPDAPMKYENKQYEQWEEATYVICEVLAWRGIWLSEERRRIGNVDVGRAQYLGLPYYGRWLLAVARVLVEKHHIGLTELTERMAEVKARYADGLDGGKPEAQPKFEGDGSQVKRNEHHRHAVGKGDPQVYAGLAGQPKFAVGDAVRVRELPVLFYTRTPEYTRGATGVIAKVAYESPAAEDETWDRPDATPEWFYVVRFNQSELWHGYTGTATDTLQTELPERWLEAAS
>NC_008705.1|WP_011562630.1|5582077_5582785_+|thiocyanate-hydrolase-subunit-gamma
MTHDHDHDHDRTVKPMVDEITDFEVLEIALRELCIEKGIFTAEEHRHFTEFAEQIGPTPAARLVARAWLDPDFKDLALREPMTASKEVGVDWMEPTGFGTPSDFTAFEILADTPGLHHVIVCALCSCYPRPILGNSPEWYRTPNYRRRLVRWPRQVLAEFGLYLPDDVEVRVQDSNQKHRFMVMPMRPEGTDGWTEDQLAEIVTRDCLIGVALPKPGVTTNVIVDTRPAVHPITD
>NC_008705.1|WP_011562631.1|5582789_5583140_+|hypothetical-protein
MTAPEPIETLARIVERGQVWPRMAAKYGVENPVPPWKTSLDGLCDALDHGACRDTNVPTFKERRDEEDSLSATVYADLPYPENQLVSLAHSLLARGVIDEAELRQRLSSIRARLEA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_008705_3	3.1\|4642640\|33\|NC_008705\|CRISPRCasFinder	4642640-4642672	33	NC_015727	Cupriavidus necator N-1 plasmid pBB1, complete sequence	522395-522427	8	0.758

1. spacer 3.1|4642640|33|NC_008705|CRISPRCasFinder matches to NC_015727 (Cupriavidus necator N-1 plasmid pBB1, complete sequence) position: , mismatch: 8, identity: 0.758

cccagcccgtcgtgccgagcgcccaacagaccg	CRISPR spacer
ccttgatggtcgtgccgagcgccaaatagacct	Protospacer
**. * . *************** **.*****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1534483 : 1600219

Corynebacterium_phage(15.38%)

protease,transposase,integrase

attL 1546473:1546532|attR 1598928:1600345

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011558824.1\|1534483_1535875_-\|protease	zinc-dependent metalloprotease	NA	NA	NA	NA
WP_011768129.1\|1535966_1536995_+	PDZ domain-containing protein	NA	NA	NA	NA
WP_011558826.1\|1537079_1540091_+	UPF0182 family protein	NA	NA	NA	NA
WP_011558827.1\|1540134_1543560_+	AAA family ATPase	NA	NA	NA	NA
WP_011558828.1\|1543662_1545051_+	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_011558829.1\|1545636_1546428_-	hypothetical protein	NA	NA	NA	NA
1546473:1546532	attL	NA	NA	NA	NA
WP_011558258.1\|1546516_1547764_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	5.8e-80	42.4
WP_011558830.1\|1547883_1548201_-	hypothetical protein	NA	NA	NA	NA
WP_153266286.1\|1548426_1549209_-	hypothetical protein	NA	NA	NA	NA
WP_011558832.1\|1549289_1550618_-\|integrase	site-specific integrase	A0A1B0T6A8	Bacillus_phage	6.9e-47	30.3
WP_167535178.1\|1550614_1550797_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_011558833.1\|1550789_1551599_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_011558834.1\|1552278_1553007_+	hypothetical protein	NA	NA	NA	NA
WP_011558835.1\|1553046_1553301_+	hypothetical protein	NA	NA	NA	NA
WP_011558836.1\|1553425_1553677_+	hypothetical protein	NA	NA	NA	NA
WP_011558837.1\|1553855_1554434_+	hypothetical protein	NA	NA	NA	NA
WP_011558838.1\|1554433_1556884_+	hypothetical protein	V5UPQ7	Mycobacterium_phage	2.5e-18	30.2
WP_011558839.1\|1556880_1557642_+	hypothetical protein	NA	NA	NA	NA
WP_011558840.1\|1557710_1562282_-	relaxase domain-containing protein	NA	NA	NA	NA
WP_011558841.1\|1562486_1563053_+	hypothetical protein	NA	NA	NA	NA
WP_011558842.1\|1563257_1563839_+	hypothetical protein	NA	NA	NA	NA
WP_011558843.1\|1564122_1565097_-	sterol desaturase family protein	NA	NA	NA	NA
WP_011558844.1\|1565151_1565925_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011558845.1\|1566172_1567258_+	C40 family peptidase	A0A1W6DXV0	Rhodococcus_phage	1.1e-15	44.3
WP_011558846.1\|1567440_1568280_-	hypothetical protein	NA	NA	NA	NA
WP_011558847.1\|1568503_1569190_+	DUF305 domain-containing protein	NA	NA	NA	NA
WP_011558848.1\|1569205_1570390_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	7.0e-27	27.1
WP_011558849.1\|1570386_1571184_-	response regulator transcription factor	Q6XM27	Feldmannia_irregularis_virus	4.2e-07	31.2
WP_153266287.1\|1571167_1571476_+	hypothetical protein	NA	NA	NA	NA
WP_011558850.1\|1571506_1572910_-	NlpC/P60 family peptidoglycan endopeptidase RipA	A0A1J0GW44	Streptomyces_phage	2.1e-14	38.6
WP_011558851.1\|1573326_1573689_+	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_041310073.1\|1573688_1574609_+	M56 family metallopeptidase	NA	NA	NA	NA
WP_011558853.1\|1574797_1575385_+	hypothetical protein	NA	NA	NA	NA
WP_011558854.1\|1575487_1576603_+	PLP-dependent cysteine synthase family protein	NA	NA	NA	NA
WP_011558855.1\|1576599_1577859_+	MFS transporter	NA	NA	NA	NA
WP_011558856.1\|1577974_1578760_+	response regulator transcription factor	NA	NA	NA	NA
WP_011558857.1\|1578834_1579605_-	NlpC/P60 family peptidoglycan endopeptidase RipB	NA	NA	NA	NA
WP_011558858.1\|1580118_1581339_-	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_011558859.1\|1581911_1582748_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_011768132.1\|1583017_1583230_+	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_011558861.1\|1583226_1584183_+	hypothetical protein	NA	NA	NA	NA
WP_011558862.1\|1584217_1586500_+	copper-translocating P-type ATPase	A0A218MNH6	uncultured_virus	2.2e-85	33.7
WP_011558863.1\|1586518_1586794_+	YHS domain-containing protein	NA	NA	NA	NA
WP_011558864.1\|1586872_1587202_+	metal-sensitive transcriptional regulator	NA	NA	NA	NA
WP_011558865.1\|1587391_1587682_+	hypothetical protein	NA	NA	NA	NA
WP_085975375.1\|1587757_1588896_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	6.3e-33	34.8
WP_011768134.1\|1589089_1589317_+	DUF2933 domain-containing protein	NA	NA	NA	NA
WP_011558867.1\|1589352_1590099_+	isoprenylcysteine carboxylmethyltransferase family protein	NA	NA	NA	NA
WP_011558868.1\|1590212_1590815_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	3.6e-11	25.8
WP_011558869.1\|1590811_1592314_+	ABC transporter permease	NA	NA	NA	NA
WP_011558870.1\|1592310_1592718_+	hypothetical protein	NA	NA	NA	NA
WP_011558871.1\|1593046_1595353_+	heavy metal translocating P-type ATPase	A0A218MNH6	uncultured_virus	9.6e-89	33.6
WP_085975370.1\|1595831_1597092_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	5.8e-72	53.4
WP_011558873.1\|1597618_1597888_+	hypothetical protein	NA	NA	NA	NA
WP_011558874.1\|1597933_1598788_-	hypothetical protein	NA	NA	NA	NA
WP_011558258.1\|1598971_1600219_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	5.8e-80	42.4
1598928:1600345	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1818999 : 1864456

Leptospira_phage(60.0%)

transposase,integrase

attL 1820019:1820034|attR 1823961:1823976

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011768156.1\|1818999_1820181_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	3.6e-63	40.3
1820019:1820034	attL	NA	NA	NA	NA
WP_041310610.1\|1820140_1821250_+\|integrase	site-specific integrase	A0A220NQQ9	Corynebacterium_phage	1.2e-12	33.3
WP_011562840.1\|1821294_1823460_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_011562839.1\|1823449_1823860_+	hypothetical protein	NA	NA	NA	NA
WP_011559084.1\|1824390_1825290_+	alpha/beta fold hydrolase	NA	NA	NA	NA
1823961:1823976	attR	NA	NA	NA	NA
WP_011559085.1\|1825289_1826606_+	aromatic ring-hydroxylating dioxygenase subunit alpha	NA	NA	NA	NA
WP_011559086.1\|1826608_1827121_+	aromatic-ring-hydroxylating dioxygenase subunit beta	NA	NA	NA	NA
WP_011768159.1\|1827157_1828387_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_011768160.1\|1828406_1829360_+	extradiol ring-cleavage dioxygenase	NA	NA	NA	NA
WP_011559089.1\|1829893_1830673_+	class II aldolase/adducin family protein	NA	NA	NA	NA
WP_013470377.1\|1830909_1831761_+	3-(cis-5,6-dihydroxycyclohexa-1, 3-dien-1-yl)propanoate dehydrogenase	NA	NA	NA	NA
WP_011768161.1\|1831773_1832664_+	glyoxalase	NA	NA	NA	NA
WP_011559093.1\|1832736_1834137_+	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_011559094.1\|1834201_1834720_+	aromatic-ring-hydroxylating dioxygenase subunit beta	NA	NA	NA	NA
WP_011559095.1\|1834768_1834987_+	hypothetical protein	NA	NA	NA	NA
WP_085975375.1\|1836488_1837626_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	6.3e-33	34.8
WP_011559096.1\|1837843_1838953_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_011559097.1\|1838978_1839983_-	ketopantoate reductase family protein	NA	NA	NA	NA
WP_011559098.1\|1839982_1840960_-	dihydrodipicolinate synthase family protein	NA	NA	NA	NA
WP_041309542.1\|1841234_1841984_-	IclR family transcriptional regulator	NA	NA	NA	NA
WP_011855201.1\|1842056_1842854_+	protocatechuate 3,4-dioxygenase subunit beta	NA	NA	NA	NA
WP_011559101.1\|1842853_1843423_+	protocatechuate 3,4-dioxygenase subunit alpha	NA	NA	NA	NA
WP_011559102.1\|1843419_1844625_+	fumarate lyase	NA	NA	NA	NA
WP_011559103.1\|1844621_1845803_+	4-carboxymuconolactone decarboxylase	NA	NA	NA	NA
WP_011559104.1\|1845799_1846498_+	3-oxoacid CoA-transferase subunit A	NA	NA	NA	NA
WP_011559105.1\|1846494_1847217_+	3-oxoacid CoA-transferase subunit B	NA	NA	NA	NA
WP_011559106.1\|1847281_1848016_+	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_011559107.1\|1848008_1848602_+	CAP domain-containing protein	NA	NA	NA	NA
WP_011768164.1\|1848812_1849301_+	cupin domain-containing protein	NA	NA	NA	NA
WP_011559109.1\|1849311_1849665_+	DUF732 domain-containing protein	NA	NA	NA	NA
WP_085975375.1\|1849903_1851041_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	6.3e-33	34.8
WP_011559096.1\|1851258_1852368_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_011559097.1\|1852393_1853398_-	ketopantoate reductase family protein	NA	NA	NA	NA
WP_011559098.1\|1853397_1854375_-	dihydrodipicolinate synthase family protein	NA	NA	NA	NA
WP_041309542.1\|1854649_1855399_-	IclR family transcriptional regulator	NA	NA	NA	NA
WP_011855201.1\|1855471_1856269_+	protocatechuate 3,4-dioxygenase subunit beta	NA	NA	NA	NA
WP_011559101.1\|1856268_1856838_+	protocatechuate 3,4-dioxygenase subunit alpha	NA	NA	NA	NA
WP_011559102.1\|1856834_1858040_+	fumarate lyase	NA	NA	NA	NA
WP_011559103.1\|1858036_1859218_+	4-carboxymuconolactone decarboxylase	NA	NA	NA	NA
WP_011559104.1\|1859214_1859913_+	3-oxoacid CoA-transferase subunit A	NA	NA	NA	NA
WP_011559105.1\|1859909_1860632_+	3-oxoacid CoA-transferase subunit B	NA	NA	NA	NA
WP_011559106.1\|1860696_1861431_+	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_011559107.1\|1861423_1862017_+	CAP domain-containing protein	NA	NA	NA	NA
WP_011768164.1\|1862227_1862716_+	cupin domain-containing protein	NA	NA	NA	NA
WP_011559109.1\|1862726_1863080_+	DUF732 domain-containing protein	NA	NA	NA	NA
WP_085975375.1\|1863318_1864456_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	6.3e-33	34.8

DBSCAN-SWA_3

1971703 : 1979429

Bacillus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011559210.1\|1971703_1972561_+	SDR family oxidoreductase	W8CYX9	Bacillus_phage	2.9e-06	37.2
WP_011559211.1\|1972568_1973741_-	AAA family ATPase	A0A077SLJ9	Escherichia_phage	1.4e-56	35.7
WP_011559212.1\|1973750_1974818_-	DNA polymerase IV	F1C5A5	Cronobacter_phage	1.0e-13	26.5
WP_011559213.1\|1974821_1975424_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011559214.1\|1975519_1976086_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	1.2e-08	33.1
WP_011559215.1\|1976551_1976803_+	redoxin NrdH	V5UN81	Mycobacterium_phage	1.6e-21	64.5
WP_011559216.1\|1976835_1977294_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	NA	NA	NA	NA
WP_082947857.1\|1977260_1979429_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	1.5e-205	51.0

DBSCAN-SWA_4

3086612 : 3099846

Streptomyces_phage(22.22%)

integrase,portal,terminase,capsid

attL 3083487:3083502|attR 3098977:3098992

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
3083487:3083502	attL	NA	NA	NA	NA
WP_011768245.1\|3086612_3087071_-	transglycosylase family protein	A0A1J0GVU2	Streptomyces_phage	1.8e-26	58.7
WP_011560302.1\|3087500_3087821_-	hypothetical protein	NA	NA	NA	NA
WP_011560303.1\|3087820_3088666_-\|capsid	phage major capsid protein	Q7Y410	Yersinia_phage	5.6e-10	24.2
WP_011560304.1\|3088912_3089368_-	hypothetical protein	NA	NA	NA	NA
WP_011560305.1\|3089364_3089955_-	hypothetical protein	NA	NA	NA	NA
WP_011560306.1\|3089951_3091271_-\|portal	phage portal protein	A0A1B3B111	Gordonia_phage	3.2e-36	30.5
WP_011560307.1\|3091267_3092737_-\|terminase	terminase	Q9T214	Streptomyces_phage	2.6e-55	35.4
WP_011560308.1\|3092736_3093111_-	HNH endonuclease	U5PTU3	Clavibacter_phage	3.0e-16	53.7
WP_011560309.1\|3093490_3093736_-	hypothetical protein	NA	NA	NA	NA
WP_011560310.1\|3093732_3094077_-	hypothetical protein	NA	NA	NA	NA
WP_041309710.1\|3094069_3094252_-	hypothetical protein	NA	NA	NA	NA
WP_011560311.1\|3094248_3095349_-	AAA family ATPase	A0A2P1CJ11	Microbacterium_phage	5.5e-10	29.3
WP_011560312.1\|3095345_3095621_-	hypothetical protein	NA	NA	NA	NA
WP_011560313.1\|3095617_3095986_-	hypothetical protein	NA	NA	NA	NA
WP_011560314.1\|3095982_3096252_-	helix-turn-helix domain-containing protein	A0A2D1GF53	Mycobacterium_phage	4.8e-08	58.2
WP_011768246.1\|3096284_3096905_+	hypothetical protein	NA	NA	NA	NA
WP_011560316.1\|3096901_3098041_+\|integrase	site-specific integrase	A0A023ZX87	Mycobacterium_phage	1.2e-87	47.2
WP_011560317.1\|3098268_3099846_+	deoxyribodipyrimidine photo-lyase	A0A1V0CPG0	Kaumoebavirus	1.1e-40	32.7
3098977:3098992	attR	NA	NA	NA	NA

DBSCAN-SWA_5

4410505 : 4418691

Gordonia_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011561485.1\|4410505_4411741_+	exodeoxyribonuclease VII large subunit	A0A1B3AYB4	Gordonia_phage	1.3e-68	51.9
WP_011561486.1\|4411727_4411940_+	exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
WP_011561487.1\|4412003_4413119_+	NAD-dependent epimerase/dehydratase family protein	Q76TT0	Molluscum_contagiosum_virus	9.2e-29	33.0
WP_011561488.1\|4413128_4413449_-	hypothetical protein	NA	NA	NA	NA
WP_011561489.1\|4413523_4414240_-	MgtC/SapB family protein	G3MA03	Bacillus_virus	1.4e-14	44.4
WP_011561491.1\|4414554_4416099_+	arylsulfatase	A0A2P0VMN7	Tetraselmis_virus	9.4e-157	52.1
WP_011561492.1\|4416098_4417007_+	haloacid dehalogenase-like hydrolase	NA	NA	NA	NA
WP_011561493.1\|4416999_4417875_+	formylglycine-generating enzyme family protein	A0A075BSL8	Microcystis_phage	2.3e-14	28.9
WP_041310282.1\|4417926_4418691_+	SDR family oxidoreductase	A0A0M4JSW6	Mollivirus	2.0e-11	42.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_008704

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_008703

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NC_008705

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection