CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_009337	Chlorobium phaeovibrioides DSM 265, complete genome	2 crisprs	WYL,csa3,DEDDh,RT,Cas9_archaeal,cas3,cas3HD,cas5,cas8c,cas7,cas4,cas1,cas2	0	4	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_009337_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009337_1

1461368-1461602

TypeI

I-C

Consensus_repeat	Method
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	PILER-CR
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CRISPRCasFinder
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CRT

3 spacers

cas2,cas1,cas4,cas7,cas8c,cas5,cas3,cas3HD

The CRISPR arrays of NC_009337_1

>merge|NC_009337|1|1461368-1461602|PILER-CR,CRISPRCasFinder,CRT
GTCGCGCCCTTCACGGGCGCGTGGATTGAAACAGTTTTCTCAGGGAGCTACGCCGGCGCAACCGGATCGTCGCGCCCTTCACGGGCGCGTGGATTGAAACTGGCAGTAAAGCCCAGTGTCAGTACGCGACTGGGTCGCGCCCTTCACGGGCGCGTGGATTGAAACCAGTCCCACTCCGAGATAGCCAGAGCCCGGTTGAAAGGTCGCGCCCTTCACGGGCGCGTGGATTGAAACG

>NC_009337|1|1|1461368-1461601|PILER-CR
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	AGTTTTCTCAGGGAGCTACGCCGGCGCAACCGGATC
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	TGGCAGTAAAGCCCAGTGTCAGTACGCGACTGG
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CAGTCCCACTCCGAGATAGCCAGAGCCCGGTTGAAAG
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC

>NC_009337|1|1|1461368-1461602|CRISPRCasFinder
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	AGTTTTCTCAGGGAGCTACGCCGGCGCAACCGGATC
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	TGGCAGTAAAGCCCAGTGTCAGTACGCGACTGG
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CAGTCCCACTCCGAGATAGCCAGAGCCCGGTTGAAAG
GTCGCGCCCTTCACGGGCGCGTGGATTGAAACG

>NC_009337|1|1|1461368-1461601|CRT
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	AGTTTTCTCAGGGAGCTACGCCGGCGCAACCGGATC
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	TGGCAGTAAAGCCCAGTGTCAGTACGCGACTGG
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CAGTCCCACTCCGAGATAGCCAGAGCCCGGTTGAAAG
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_009337.1\|WP_011890547.1\|1467264_1468455_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|237657
NC_009337.1\|WP_011890544.1\|1463993_1465424_+\|UDP-N-acetylmuramate--alanine-ligase	unknown	unknown	gnl\|CDD\|223844
NC_009337.1\|WP_041470197.1\|1470290_1471169_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	unknown	unknown	gnl\|CDD\|236467
NC_009337.1\|WP_041470198.1\|1471377_1472118_+\|DUF4412-domain-containing-protein	unknown	unknown	gnl\|CDD\|373032
NC_009337.1\|WP_011890537.1\|1456625_1458341_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|187887
NC_009337.1\|WP_011890546.1\|1466723_1467194_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372273
NC_009337.1\|WP_081424444.1\|1460899_1461190_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_009337.1\|WP_011890535.1\|1453898_1455896_+\|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NC_009337.1\|WP_011890533.1\|1452046_1453159_-\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	unknown	unknown	gnl\|CDD\|99740
NC_009337.1\|WP_011890538.1\|1458367_1459216_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl\|CDD\|377458
NC_009337.1\|WP_011890548.1\|1468478_1469063_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|271355
NC_009337.1\|WP_011890552.1\|1472169_1473615_+\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236327
NC_009337.1\|WP_011890532.1\|1450591_1451920_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NC_009337.1\|WP_011890540.1\|1459864_1460896_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NC_009337.1\|WP_011890536.1\|1455918_1456629_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	gnl\|CDD\|187534
NC_009337.1\|WP_155811660.1\|1461704_1462858_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_009337.1\|WP_011890534.1\|1453670_1453898_+\|CRISPR-associated-endonuclease-Cas3''	cas3HD	cd09641_cas3HD_CAS-I	gnl\|CDD\|193608
NC_009337.1\|WP_011890545.1\|1465550_1466555_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|223135
NC_009337.1\|WP_011890549.1\|1469081_1470155_-\|heat-inducible-transcription-repressor-HrcA	unknown	unknown	gnl\|CDD\|273017
NC_009337.1\|WP_011890539.1\|1459208_1459868_+\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|187768

Protein	Function_ID	Function_description	E-value
NC_009337.1\|WP_011890547.1\|1467264_1468455_-\|molecular-chaperone-DnaJ	gnl\|CDD\|237657	PRK14281, PRK14281, chaperone protein DnaJ; Provisional.	0
NC_009337.1\|WP_011890544.1\|1463993_1465424_+\|UDP-N-acetylmuramate--alanine-ligase	gnl\|CDD\|223844	COG0773, MurC, UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane].	7.9249e-135
NC_009337.1\|WP_041470197.1\|1470290_1471169_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	gnl\|CDD\|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	2.08295e-113
NC_009337.1\|WP_041470198.1\|1471377_1472118_+\|DUF4412-domain-containing-protein	gnl\|CDD\|373032	pfam14371, DUF4412, Domain of unknown function (DUF4412). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is typically between 75 and 104 amino acids in length.	2.43743e-90
NC_009337.1\|WP_011890537.1\|1456625_1458341_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	0
NC_009337.1\|WP_011890546.1\|1466723_1467194_+\|hypothetical-protein	gnl\|CDD\|372273	pfam12724, Flavodoxin_5, Flavodoxin domain. This is a family of flavodoxins. Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.	2.37452e-06
NC_009337.1\|WP_081424444.1\|1460899_1461190_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	8.80881e-32
NC_009337.1\|WP_011890535.1\|1453898_1455896_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	1.33531e-52
NC_009337.1\|WP_011890533.1\|1452046_1453159_-\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	gnl\|CDD\|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	2.76667e-144
NC_009337.1\|WP_011890538.1\|1458367_1459216_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.0299e-152
NC_009337.1\|WP_011890548.1\|1468478_1469063_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|271355	cd00446, GrpE, nucleotide exchange factor GrpE. GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.	1.38784e-43
NC_009337.1\|WP_011890552.1\|1472169_1473615_+\|proline--tRNA-ligase	gnl\|CDD\|236327	PRK08661, PRK08661, prolyl-tRNA synthetase; Provisional.	0
NC_009337.1\|WP_011890532.1\|1450591_1451920_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.07115e-51
NC_009337.1\|WP_011890540.1\|1459864_1460896_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NC_009337.1\|WP_011890536.1\|1455918_1456629_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	1.99451e-104
NC_009337.1\|WP_155811660.1\|1461704_1462858_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.06451e-31
NC_009337.1\|WP_011890534.1\|1453670_1453898_+\|CRISPR-associated-endonuclease-Cas3''	gnl\|CDD\|193608	cd09641, Cas3''_I, CRISPR/Cas system-associated protein Cas3''. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; HD-like nuclease, specifically digesting double-stranded oligonucleotides and preferably cleaving at G:C pairs; signature gene for Type I.	5.08677e-09
NC_009337.1\|WP_011890545.1\|1465550_1466555_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	0
NC_009337.1\|WP_011890549.1\|1469081_1470155_-\|heat-inducible-transcription-repressor-HrcA	gnl\|CDD\|273017	TIGR00331, Heat-inducible_transcription_repressor_HrcA, heat shock gene repressor HrcA. HrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures. In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene. [Regulatory functions, DNA interactions].	1.67048e-104
NC_009337.1\|WP_011890539.1\|1459208_1459868_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|187768	cd09637, Cas4_I-A_I-B_I-C_I-D_II-B, CRISPR/Cas system-associated protein Cas4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster.	7.29344e-44

>NC_009337.1|WP_081424444.1|1460899_1461190_+|CRISPR-associated-endonuclease-Cas2
MMVLVTYDVNTETPAGRRRLRRIAKTCQNFGQRVQFSVFECSVDPAQWIKFRAKLIHEMNPEQDSLRFYFLGSNWQHRIEHAGTKEPRDLEGVLIL
>NC_009337.1|WP_011890540.1|1459864_1460896_+|type-I-C-CRISPR-associated-endonuclease-Cas1
MKKHLNTLFVTTQGTYLSKEGECAVISIDKVEKTRIPLHMLQGIICFGRISFSPYLFGYCAELGITITFLTEYGKFLCLMQGPARGNILLRRAQYRLADNYEQSAMIARSFIIGKIGNARITLSRTMRDHAEKVDLVQMRRAQHLLAGCIRKIQTITDQEIIRGIEGEAAKIYFDVFDQCITASDPLLRFSGRNRRPPLDRINCLLSFLYTLLTHDIRSALESTGLDPSAGFLHKDRPGRPSLALDVLEEFRSYIADRLTLSLINRGQIQANDFTISETGAIKLNDDARKTVLTAYQQRKQEEIEHPFIKEKMAIGLLWHMQAMLLARFIRGELDTYPPFVWR
>NC_009337.1|WP_011890539.1|1459208_1459868_+|CRISPR-associated-protein-Cas4
MAELAYYEESDFVTLSSLQHFIFCPRQCALIHLEQIWVENAFTAEGREMHELVDKGETSYRAGVKITRSLSLKSRILGLSGVADVVEWHHSNKESQPFPVEYKRGKPKGHNADKIQLCAQALCLEEMLSVHIPAGALFYGQTKHRMDVPFDSQLRDQTINAAKEVHDLIHGGITPMPEPGAKCKHCSLLEQCMPDVIAHGRSAKSYLQKLFHDLQEDSF
>NC_009337.1|WP_011890538.1|1458367_1459216_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MDAIKKRYDFVLLFDVQDGNPNGDPDAGNLPRIDAETGMGLVSDVCLKRKVRNYVQLAGQEIFIKEKGVLNTLIAESHEQPEVKSKTKGDKTEAARSWMCSKYYDIRTFGAVMSTGENAGQVRGPVQITFARSVEPVVALEHSITRMAVATEAEAEKQDGGNRTMGRKYTIPYGLYLAHGFVSANLANQTGFSEKDLQLFWDALLNMFEHDRSAARGMMSTRGLYIFEHNSALGNAPAHSLFERISVSRKNPASGPARSFAEYSIDINQANLEPVSLIKKLG
>NC_009337.1|WP_011890537.1|1456625_1458341_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MILQALNDYYQRKAADSLSGIAPEGFEWKEIPFIVVIDQKGTFVTIEDTREGDGKKKTAKRFLVPAAEKRTVGIKANLLWDNAEYTLGANPRNRADVHERKSAFIHRLRSEFANDEAEKKVEPLIRFLENEPLAKIESATIDASLWQDLFEKNANVIFRIAEAPEPTIIDELRPYIAAPIEGDGGICLVSGTQGAISRLHASIKGIRGAQSSGAALVSFNLPPFQSYGKTQNYNAPVSESAAFAYTTALNTLLGKESKNKLTIGDTATTVFWSEKSTAFETDFAAFFSFPPKDDPDADVRAVKKLYDGIYTGNNTTDSETDFYVLGLAPNAARISIRFWQKGTVKSLSQNIRKHFDDLEIIRSKNDKNHFALFWILSAMAQENKVDNIPPNLAGQIINAVLNGTQYPTTMHHQVIRRIRATQNVTRLQAAILKAYLNRFHRIHSTNEKEITVTLDMENNSPGYRLGRLFAILEKIQEEANPGINATIRDRFYGAASSTPVTVFPQLLKLKNHHLAKLSNTGRKVNFERMLAEVFSGITTEMPAHLAMGDQARFAIGYYHQRQALFESKTQS
>NC_009337.1|WP_011890536.1|1455918_1456629_+|type-I-C-CRISPR-associated-protein-Cas5
MDYHDKTFCLEVEGDYACFTRPEMKVERVSYDVITPSAARAIFEAIFWKPAIHWKITKIEVLKPIKWISFRRNEVGAVASPQSNGIIIEDSRQQRAGLFLRDVAYRLHAELVFIPASKRTEAKKAAKKTLIDDAEIAAAGKDENPAKYQGMFERRARKGQCFNQPYLGCREFSCNFRLVDNADHERAPILETRDLGFMLYDLDFKNPESPSPAFYRPQIINGIIDVPSWDSEEVKK
>NC_009337.1|WP_011890535.1|1453898_1455896_+|CRISPR-associated-helicase-Cas3'
MGKIDHSSAGALHAVNKNGRVGRILAYLIAGHHAGLPNWTYEPHGGGALSDRLSTIENLYAALEGKPPEELLAKQLPTSIPCGSGFRDNYEAVHLWVRMLYSCLVDADFLDTESFMAPEKTKERHQEWTLDKLKPLFDKHIDQLQQDANATPVNTNRKAILEECKNKASLAPGVFSLTVPTGGGKTLSSMAFALEHAIKYKKKRVIIAIPYTSIIEQTAAIFRKIFGSDAVLEHHSNLDPDRETQSARLSSENWDAPIIVTTNVQLFESLFAARSSSCRKLHNLVNSVIILDEAQTLPTGFLQPILSSLKVLTEYFKASLLLCTATQPILTERIGSDDNILNGFKAGSVREIISNPNTLFEIFQRVKVYGPKSREKLQWEEVKDQLCQHPQVLCIVNTRKDCSELHQLMPEGTVHLSALMCPEHRSEVIAAVKEQLMTNQPIRVISTQLLEAGVDIDFPVVYRAFSGLDSIAQAAGRCNREGLLDYGHVTVFNPPTPSPKGIMLKAEQAAQEVFNSNPKLAASLMPGAFQCYFRAYFNSLNNFDEQSIMDLLAGTDAREFKLQFRTAAQRFKLINNAHQHGVIVKYQSQHHDSTQLIKQLRYAGPSRYLMRRLQRFSVNVYQNDLQEMQRNGVVENIEGLWVQTAETLYNKVFGLDVKAGVNLYW
>NC_009337.1|WP_011890534.1|1453670_1453898_+|CRISPR-associated-endonuclease-Cas3''
MKPVAHLRQLEDLRWEEHLLLNHLTHVADMAAEFAAEFDNADWLRIAGSWHDLGKYNPLWQEYIRNNNGNYTEEE
>NC_009337.1|WP_011890533.1|1452046_1453159_-|DegT/DnrJ/EryC1/StrS-family-aminotransferase
MQFIDLITQKDRIRGAVMARLESIVDRAQFIMGAEVAELESQLAAFAGTRHCLSCSSGTDALLIALMAKGIGPGDAVLTTPFTFVATAEVVSLTGATPVFVDIDPVSFNIDPDGIAGAVKEAEAKGLKPKALIPVDLFGLPADYDRLESVARNHGLWILEDACQGFGGALNGRKAGSFGLVGATSFFPAKPLGCWGDGGAIFTDDDELAELMISVRVHGGGADKYSNVRIGINGRLDAMQAAVLLEKLTIFDEELLLRDRVANAYSKRLAGRVQVPVVPEGYSSAWAQYSVLASDSAEREQLMAALQKEGIPSVIYYKIPLHLQGAYADLGYCAGDFPITEDISSRIFSLPMHPYLKESEIEQVCSALLA
>NC_009337.1|WP_011890532.1|1450591_1451920_+|MFS-transporter
MKSSTEQHHLGPVILSPGVLPQHGWTFLYAAFVSIGLVTFVSIGQAYILNEHLKIPIAEQGTISGNLVFWTEIVTLLFFIPAGVLMDRIGRKPIYIAGMILLAIAYGLYPMAQSVADLTLYRIVYALGIVAVTGGLATVMVDYPAERSRGKLIAITGFLNGLGIVVLNQFFGGLPEKLIGRGFSGVEAGIIAHMSIAALALVTAIVLSVGLKGGTPVRKEERPPLKTLLTSGFTHAKNPRILLSYAAAFVARGDQSIIGTFLPLWGTTAGIAMGMNPAEAVKKGMMVFIISQAAALLWAPVIGPLIDRWNRVTALVVCMGLASAGYLSLALIENPHDSFSTLYFVLLGIGQISAFLGSQSLIGQEAPREARGSVIGMFNISGAIGILIITTLGGRMFDQLSPKAPFLVVGAINLLVMLGGIYVRIKAPGTISVRASAIDSEK
>NC_009337.1|WP_155811660.1|1461704_1462858_+|IS3-family-transposase
MKKNRRKFNPEFKTKVVLEALSERLTLTELAQKYELHPNQITLWKREFLDRASEVFSKSDKTQKAEQDSKQETEELYKTIGQLKVEVDWLKKKLVVKTLSVRRSMIEKEHPKISLNRQCELLSIHRSGLYYQPRRSTKLNRELMRLVDEQYLLKPYYGVYRMWEWLVKDKGYKVNIKRVRRLCRLMGLEAIGPKPNTSKPAPGHKVYPYLLRGLTIQRCNQVWATDITYVPMAQGFMYLMAVIDLKSRYVLNWSVSNTMDATWCAEVFREAVSMHGAPEILNTDQGSQFTSEVFTTAVIKEAKVKLSMDGRGRAIDNVFIERLWRSVKYEYIYYRPPVDGIELYQGLKNWFNDYNTTRRHKSLNGEVPATVYYSQKVQAPEAA
>NC_009337.1|WP_011890544.1|1463993_1465424_+|UDP-N-acetylmuramate--alanine-ligase
MSSLYFIGIGGTAMASVAVALSHLGHAITGSDTGLYPPMSTYLDEHHIRYFSGFSADNLQSVKPDMVVVGNAVSRGNEELEYALNEKMELVAMPDLVRRELIGKNTSIVVAGTHGKTTTTSIVAWLLESGGLRPGFLVGGIPENFGIGCRPSGRSDEGFFVSEGDEYDTAFFDKRSKFMLYRPDIAIINNIEFDHADIFSSLEEIKRSFRLLVNLIPSNGALIVNGDDPVAMEVSSKALCRVETFGLTDGCDWTAQNIRVEENGSSFDLYYKGGFERRFNAPLFGSYNILNTLASIAVATLSGMTLDMTAEGLREFLRPKRRMETVGTYEGNITVIEDFAHHPTAIRVTLEAIKERWPERRIITCFEARSNTTTRNIFQKELAECFGPADIVVLGKVHRPERYGPEGSLDTARLKKELEEQGKTVFLGGSDPKNYPADIVGFLESCRKKDDVVLMLTNGSFAGLKTALTESFQKKR
>NC_009337.1|WP_011890545.1|1465550_1466555_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MTKVKVGINGFGRIGRLVFRQAMDNPKFEIVAINDLCDPKTLAHLLKYDSTHKKFNGEVSVEDGNIVVNGKTITICAERDPANLPWKALGCDLVVESTGIFTSREAASKHIAAGAKKVIISAPAKDKIDATIVLGVNENLITGNEQIISNASCTTNCLAPMVKVLEDSFGLEKGFMTTIHAYTNDQNILDLPHKDLRRARSAGVSMIPTSTGAAKAIGEVIPELAGKLDGFAVRVPVPDGSMTDLTAILKKPATKEEINAAMKAAADGPMKGYLEYCTDPIVSQDIVGNPHSSIFDSLLTMSSGTMVKTVSWYDNELGYSTRVVDLLEIYSNFV
>NC_009337.1|WP_011890546.1|1466723_1467194_+|hypothetical-protein
MKAIILYDSRSEGGSTDRLVDAIGQKLAGKGMDVEKARCRAQADYSFISEFDLVIMGAPVYYLMVSSQLLGALIQSNLSNMLKNKNTALFLACGSPQPMAELLYMPQMKMNLQGSRILAEKVFAPAETSDMEVIGEYVDTIYAEWLKEEERRGKRK
>NC_009337.1|WP_011890547.1|1467264_1468455_-|molecular-chaperone-DnaJ
MKKDYYEILGVGRSADKDEIKKAYRKLALKYHPDKNPDNKDAEDHFKEVNEAYEVLSNDDKRRRYDQFGHAGVGSSAASGGGAGAYGAGGADFSDIFSAFNDMFGGGGGGRGRGGFEDAFGGGQRRSRASAGIQGTDLKIRLKLSLEEIAKGVEKTLKIKKQVPCKECNGSGSKTGATETCPTCHGTGEVRQASKTMFGQFVNIAACPTCGGEGRIVKDRCPACYGEGIKQGEVTVKVTVPAGVQDNNYLTLRGQGNSGPRGGASGDLIVVIEEKPHEFFVRNGDDVIYSLAVSFPDLVLGTKVEVPTLDGAIKMTIPPSTQPETMLRIPGHGIGHLRGSGKGDQYVRVNVFVPKDLSATDKELLKGLRKSPGISPEAHGTGTEKSFFEKMKDIIG
>NC_009337.1|WP_011890548.1|1468478_1469063_-|nucleotide-exchange-factor-GrpE
MMKHRDKPMPENEEPLQEQEGTLHAEPAEPQPQKEDRVAELEAALTAEKEQSGKLRDEVLRRAAEFENFRKQKEREAVQSSLRAKETILRELLPVLDDVERVLANAPEPEAIPVAAKPFIEGVELMKKNLDRWLEEKGVKPIEAIGLKLDVDFHEAISQIEHPEAEPDTIVEQYQTGYLLGDRVIRHAKVIVSR
>NC_009337.1|WP_011890549.1|1469081_1470155_-|heat-inducible-transcription-repressor-HrcA
MGSRELSLRERQVLGIIIQSYVVTAAPVGSRYIARNYSLGLSDATIRNVMADLEDEGYIHQPHTSAGRIPTDLGYRYYVDLIMKVQRIDEDEKRRMETDYGQIAMEHPGTSRDVLLSAAKVLGCISRQLSVVLSPTLSDAVFERLDMVLLSSTRMMVILSIHSLFVKTIVMELPLEVSRKMIEEVSNVINERLAGLTLSEIRRSIAHRLAGSHGDGALKDLIVRSAGSLFDESPIFERLYISGTEYIVDQPEFKQPERVRELITMIEDKFSVARLVEKSGHMSEALRPSDMDVTISIGSENSTREAEDLTIVSTPYYAGNMVGRLGILGPKRMDYEHAVRVLNYMADSLTATLTDAN
>NC_009337.1|WP_041470197.1|1470290_1471169_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase
MEQVREWQVVDLLKTTEEFFSSKGVDEARIGAEMLLSQVLGLKRIELYLNYQRPVYPDELERFRRLCRQRLEGRPVQYIAGEQFFYGLQFHVDERVLIPRPETELLVEHALGFLENTQSARVMDIGTGSGCIAVTMALRNASLVLDALDCSVEALAVARGNALAHKVQDRVRFHEADIFRDSFTAPFSAGTYSLIVSNPPYIPDAEWELLQREVREYEPRLALTTPTGMECYRAIAGHAGELLKPEGVLCFEVHAEGAAAVGAIMDSSGFSAITVTKDYSGLDRIVSGRLQA
>NC_009337.1|WP_041470198.1|1471377_1472118_+|DUF4412-domain-containing-protein
MKKAAILLILLLFSIPGPSTKAAEKFSGVMEMMLTMPSGKGELTFSFGREAQRMDMFLQMDNIPAPVRSTIITRAAEPDQATLLNHDTRSWASLNLKNAAEEAILLDFDSNYTLEKLGTVKLHGYSCQLVRLTSRTEKLELWLTRDLGSFTSFSLLQRQNPHFSNSALSKKLAAAGVDGFPVKTLQHSQNGTYTMELVEAWPKSVPDSQFRVPANYTRISANTPKISKSQKEHLKNLMEKMKKFEQ
>NC_009337.1|WP_011890552.1|1472169_1473615_+|proline--tRNA-ligase
MADKITSREADYSQWYIDLVRSAKLADYSDVRGCMVIRPNGYAVWEKMQAALDRMFKETGHVNAYFPLFIPESFIAKEAEHIEGFAPECAVVTHGGGEELAEKLYVRPTSETIIWSSYKKWIQSYRDLPLLINQWANVVRWEMRTRLFLRTTEFLWQEGHTAHATPEESQEEVMRMIRVYKTFAEEYMAMPVIMGRKTDSEKFAGADETYCIEAMMQDGKALQAGTSHNLGQNFAKAFDCQFQTKEGVLDYVWATSWGVSTRLIGALIMAHSDDRGLVLPPKLATRQVVIIPILRGDKAAVLAKAESMAAELKENGIPAFVDDSEQNSPGWKFAEYELQGIPVRIEVGPRDIDKGVCIAARRDTLEKTELQLDATLAVQVSGMLSAMQADMFQKALRFREENTREVTDYETFKSAVEEGFVIAHWDGTAETEEKIKEETRATIRVLPEESDYREHYHMDEPGVCIFSGKPSSQKVVFAKAY

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Crispr_ID: NC_009337_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009337_2

1462908-1463724

TypeI

I-C

Consensus_repeat	Method
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	PILER-CR
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CRISPRCasFinder
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CRT

12 spacers

cas2,cas1,cas4,cas7,cas8c,cas5,cas3,cas3HD

The CRISPR arrays of NC_009337_2

>merge|NC_009337|2|1462908-1463724|PILER-CR,CRISPRCasFinder,CRT
GTCGCGCCCTTCACGGGCGCGTGGATTGAAACTTGTTGTCGATAAGCCCTTTGACGATGCCGAGCCGTCGCGCCCTTCACGGGCGCGTGGATTGAAACCGTGAATCTGCTGGCGGGTATACTGACGGCGCGGTCGCGCCCTTCACGGGCGCGTGGATTGAAACAGTGCAGGAAGGTACCAGTCAGAATAACCGTTAAGTCGGGCCCTTCACGGGCGCGTGGATTGAAACCGCTGACTGACATGACCAAAGCGGCTGTCGGAAGTCGCGCCCTTCACGGGCGCGTGGATTGAAACATAAACAGCTGAAAGTGAGAAACATCAAGAGAGTCGCGCCCTTCACGGGCGCGTGGATTGAAACGCCGTCTATCTTCGCCTACAGTATTACCGTCAGGTCGCGCCCTTCACGGGCGCGTGGATTGAAACATCTCTGCGGCTATGTCCGATATCAAGTATGATCGTCGCGCCCTTCACGGGCGCGTGGATTGAAACGTACTGATACAAAGGAATGCCTTGGTGTAGTTTGTCGCGCCCTTCACGGGCGCGTGGATTGAAACACGCGTAGTCATCGGATGACTACCAAAATGACTACGTCGCGCCCTTCACGGGCGCGTGGATTGAAACCTTTTTTCTTGCCGCCTATACGCCCTGACTCCTTGTCGCGCCCTTCACGGGCGCATGGATTGAAACAAAGCCGTCACTTGATAAAGAACCGTCCTCTTTGTCGCGCCCTTCACGGGTGCGTGGATTGAAACATAGTCTTTGACCGAACCAAAAAGCTGGATGGAGTCGCGCCCTTCACGGGCGCGTGGATTGAAAC

>NC_009337|2|2|1462908-1463724|PILER-CR
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	TTGTTGTCGATAAGCCCTTTGACGATGCCGAGCC
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CGTGAATCTGCTGGCGGGTATACTGACGGCGCG
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	AGTGCAGGAAGGTACCAGTCAGAATAACCGTTAA
GTCGGGCCCTTCACGGGCGCGTGGATTGAAAC	CGCTGACTGACATGACCAAAGCGGCTGTCGGAA
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	ATAAACAGCTGAAAGTGAGAAACATCAAGAGA
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	GCCGTCTATCTTCGCCTACAGTATTACCGTCAG
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	ATCTCTGCGGCTATGTCCGATATCAAGTATGATC
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	GTACTGATACAAAGGAATGCCTTGGTGTAGTTT
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	ACGCGTAGTCATCGGATGACTACCAAAATGACTAC
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CTTTTTTCTTGCCGCCTATACGCCCTGACTCCTT
GTCGCGCCCTTCACGGGCGCATGGATTGAAAC	AAAGCCGTCACTTGATAAAGAACCGTCCTCTTT
GTCGCGCCCTTCACGGGTGCGTGGATTGAAAC	ATAGTCTTTGACCGAACCAAAAAGCTGGATGGA
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC

>NC_009337|2|2|1462908-1463724|CRISPRCasFinder
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	TTGTTGTCGATAAGCCCTTTGACGATGCCGAGCC
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CGTGAATCTGCTGGCGGGTATACTGACGGCGCG
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	AGTGCAGGAAGGTACCAGTCAGAATAACCGTTAA
GTCGGGCCCTTCACGGGCGCGTGGATTGAAAC	CGCTGACTGACATGACCAAAGCGGCTGTCGGAA
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	ATAAACAGCTGAAAGTGAGAAACATCAAGAGA
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	GCCGTCTATCTTCGCCTACAGTATTACCGTCAG
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	ATCTCTGCGGCTATGTCCGATATCAAGTATGATC
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	GTACTGATACAAAGGAATGCCTTGGTGTAGTTT
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	ACGCGTAGTCATCGGATGACTACCAAAATGACTAC
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CTTTTTTCTTGCCGCCTATACGCCCTGACTCCTT
GTCGCGCCCTTCACGGGCGCATGGATTGAAAC	AAAGCCGTCACTTGATAAAGAACCGTCCTCTTT
GTCGCGCCCTTCACGGGTGCGTGGATTGAAAC	ATAGTCTTTGACCGAACCAAAAAGCTGGATGGA
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC

>NC_009337|2|2|1462908-1463724|CRT
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	TTGTTGTCGATAAGCCCTTTGACGATGCCGAGCC
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CGTGAATCTGCTGGCGGGTATACTGACGGCGCG
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	AGTGCAGGAAGGTACCAGTCAGAATAACCGTTAA
GTCGGGCCCTTCACGGGCGCGTGGATTGAAAC	CGCTGACTGACATGACCAAAGCGGCTGTCGGAA
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	ATAAACAGCTGAAAGTGAGAAACATCAAGAGA
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	GCCGTCTATCTTCGCCTACAGTATTACCGTCAG
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	ATCTCTGCGGCTATGTCCGATATCAAGTATGATC
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	GTACTGATACAAAGGAATGCCTTGGTGTAGTTT
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	ACGCGTAGTCATCGGATGACTACCAAAATGACTAC
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC	CTTTTTTCTTGCCGCCTATACGCCCTGACTCCTT
GTCGCGCCCTTCACGGGCGCATGGATTGAAAC	AAAGCCGTCACTTGATAAAGAACCGTCCTCTTT
GTCGCGCCCTTCACGGGTGCGTGGATTGAAAC	ATAGTCTTTGACCGAACCAAAAAGCTGGATGGA
GTCGCGCCCTTCACGGGCGCGTGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_009337.1\|WP_011890547.1\|1467264_1468455_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|237657
NC_009337.1\|WP_011890545.1\|1465550_1466555_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|223135
NC_009337.1\|WP_011890553.1\|1473672_1474263_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239313
NC_009337.1\|WP_041470197.1\|1470290_1471169_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	unknown	unknown	gnl\|CDD\|236467
NC_009337.1\|WP_041470198.1\|1471377_1472118_+\|DUF4412-domain-containing-protein	unknown	unknown	gnl\|CDD\|373032
NC_009337.1\|WP_011890537.1\|1456625_1458341_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|187887
NC_009337.1\|WP_011890546.1\|1466723_1467194_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372273
NC_009337.1\|WP_081424444.1\|1460899_1461190_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_009337.1\|WP_011890535.1\|1453898_1455896_+\|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NC_009337.1\|WP_011890533.1\|1452046_1453159_-\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	unknown	unknown	gnl\|CDD\|99740
NC_009337.1\|WP_011890538.1\|1458367_1459216_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl\|CDD\|377458
NC_009337.1\|WP_011890548.1\|1468478_1469063_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|271355
NC_009337.1\|WP_011890552.1\|1472169_1473615_+\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236327
NC_009337.1\|WP_011890544.1\|1463993_1465424_+\|UDP-N-acetylmuramate--alanine-ligase	unknown	unknown	gnl\|CDD\|223844
NC_009337.1\|WP_011890540.1\|1459864_1460896_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NC_009337.1\|WP_011890536.1\|1455918_1456629_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	gnl\|CDD\|187534
NC_009337.1\|WP_155811660.1\|1461704_1462858_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_009337.1\|WP_011890534.1\|1453670_1453898_+\|CRISPR-associated-endonuclease-Cas3''	cas3HD	cd09641_cas3HD_CAS-I	gnl\|CDD\|193608
NC_009337.1\|WP_011890549.1\|1469081_1470155_-\|heat-inducible-transcription-repressor-HrcA	unknown	unknown	gnl\|CDD\|273017
NC_009337.1\|WP_011890539.1\|1459208_1459868_+\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|187768

Protein	Function_ID	Function_description	E-value
NC_009337.1\|WP_011890547.1\|1467264_1468455_-\|molecular-chaperone-DnaJ	gnl\|CDD\|237657	PRK14281, PRK14281, chaperone protein DnaJ; Provisional.	0
NC_009337.1\|WP_011890545.1\|1465550_1466555_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	0
NC_009337.1\|WP_011890553.1\|1473672_1474263_-\|peroxiredoxin	gnl\|CDD\|239313	cd03015, PRX_Typ2cys, Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. The functional unit of typical 2-cys PRX is a homodimer. A unique intermolecular redox-active disulfide center is utilized for its activity. Upon reaction with peroxides, its peroxidatic cysteine is oxidized into a sulfenic acid intermediate which is resolved by bonding with the resolving cysteine from the other subunit of the homodimer. This intermolecular disulfide bond is then reduced by thioredoxin, tryparedoxin or AhpF. Typical 2-cys PRXs, like 1-cys PRXs, form decamers which are stabilized by reduction of the active site cysteine. Typical 2-cys PRX interacts through beta strands at one edge of the monomer (B-type interface) to form the functional homodimer, and uses an A-type interface (similar to the dimeric interface in atypical 2-cys PRX and PRX5) at the opposite end of the monomer to form the stable decameric (pentamer of dimers) structure.	5.88916e-106
NC_009337.1\|WP_041470197.1\|1470290_1471169_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	gnl\|CDD\|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	2.08295e-113
NC_009337.1\|WP_041470198.1\|1471377_1472118_+\|DUF4412-domain-containing-protein	gnl\|CDD\|373032	pfam14371, DUF4412, Domain of unknown function (DUF4412). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is typically between 75 and 104 amino acids in length.	2.43743e-90
NC_009337.1\|WP_011890537.1\|1456625_1458341_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	0
NC_009337.1\|WP_011890546.1\|1466723_1467194_+\|hypothetical-protein	gnl\|CDD\|372273	pfam12724, Flavodoxin_5, Flavodoxin domain. This is a family of flavodoxins. Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.	2.37452e-06
NC_009337.1\|WP_081424444.1\|1460899_1461190_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	8.80881e-32
NC_009337.1\|WP_011890535.1\|1453898_1455896_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	1.33531e-52
NC_009337.1\|WP_011890533.1\|1452046_1453159_-\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	gnl\|CDD\|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	2.76667e-144
NC_009337.1\|WP_011890538.1\|1458367_1459216_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.0299e-152
NC_009337.1\|WP_011890548.1\|1468478_1469063_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|271355	cd00446, GrpE, nucleotide exchange factor GrpE. GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.	1.38784e-43
NC_009337.1\|WP_011890552.1\|1472169_1473615_+\|proline--tRNA-ligase	gnl\|CDD\|236327	PRK08661, PRK08661, prolyl-tRNA synthetase; Provisional.	0
NC_009337.1\|WP_011890544.1\|1463993_1465424_+\|UDP-N-acetylmuramate--alanine-ligase	gnl\|CDD\|223844	COG0773, MurC, UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane].	7.9249e-135
NC_009337.1\|WP_011890540.1\|1459864_1460896_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NC_009337.1\|WP_011890536.1\|1455918_1456629_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	1.99451e-104
NC_009337.1\|WP_155811660.1\|1461704_1462858_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.06451e-31
NC_009337.1\|WP_011890534.1\|1453670_1453898_+\|CRISPR-associated-endonuclease-Cas3''	gnl\|CDD\|193608	cd09641, Cas3''_I, CRISPR/Cas system-associated protein Cas3''. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; HD-like nuclease, specifically digesting double-stranded oligonucleotides and preferably cleaving at G:C pairs; signature gene for Type I.	5.08677e-09
NC_009337.1\|WP_011890549.1\|1469081_1470155_-\|heat-inducible-transcription-repressor-HrcA	gnl\|CDD\|273017	TIGR00331, Heat-inducible_transcription_repressor_HrcA, heat shock gene repressor HrcA. HrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures. In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene. [Regulatory functions, DNA interactions].	1.67048e-104
NC_009337.1\|WP_011890539.1\|1459208_1459868_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|187768	cd09637, Cas4_I-A_I-B_I-C_I-D_II-B, CRISPR/Cas system-associated protein Cas4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster.	7.29344e-44

>NC_009337.1|WP_155811660.1|1461704_1462858_+|IS3-family-transposase
MKKNRRKFNPEFKTKVVLEALSERLTLTELAQKYELHPNQITLWKREFLDRASEVFSKSDKTQKAEQDSKQETEELYKTIGQLKVEVDWLKKKLVVKTLSVRRSMIEKEHPKISLNRQCELLSIHRSGLYYQPRRSTKLNRELMRLVDEQYLLKPYYGVYRMWEWLVKDKGYKVNIKRVRRLCRLMGLEAIGPKPNTSKPAPGHKVYPYLLRGLTIQRCNQVWATDITYVPMAQGFMYLMAVIDLKSRYVLNWSVSNTMDATWCAEVFREAVSMHGAPEILNTDQGSQFTSEVFTTAVIKEAKVKLSMDGRGRAIDNVFIERLWRSVKYEYIYYRPPVDGIELYQGLKNWFNDYNTTRRHKSLNGEVPATVYYSQKVQAPEAA
>NC_009337.1|WP_081424444.1|1460899_1461190_+|CRISPR-associated-endonuclease-Cas2
MMVLVTYDVNTETPAGRRRLRRIAKTCQNFGQRVQFSVFECSVDPAQWIKFRAKLIHEMNPEQDSLRFYFLGSNWQHRIEHAGTKEPRDLEGVLIL
>NC_009337.1|WP_011890540.1|1459864_1460896_+|type-I-C-CRISPR-associated-endonuclease-Cas1
MKKHLNTLFVTTQGTYLSKEGECAVISIDKVEKTRIPLHMLQGIICFGRISFSPYLFGYCAELGITITFLTEYGKFLCLMQGPARGNILLRRAQYRLADNYEQSAMIARSFIIGKIGNARITLSRTMRDHAEKVDLVQMRRAQHLLAGCIRKIQTITDQEIIRGIEGEAAKIYFDVFDQCITASDPLLRFSGRNRRPPLDRINCLLSFLYTLLTHDIRSALESTGLDPSAGFLHKDRPGRPSLALDVLEEFRSYIADRLTLSLINRGQIQANDFTISETGAIKLNDDARKTVLTAYQQRKQEEIEHPFIKEKMAIGLLWHMQAMLLARFIRGELDTYPPFVWR
>NC_009337.1|WP_011890539.1|1459208_1459868_+|CRISPR-associated-protein-Cas4
MAELAYYEESDFVTLSSLQHFIFCPRQCALIHLEQIWVENAFTAEGREMHELVDKGETSYRAGVKITRSLSLKSRILGLSGVADVVEWHHSNKESQPFPVEYKRGKPKGHNADKIQLCAQALCLEEMLSVHIPAGALFYGQTKHRMDVPFDSQLRDQTINAAKEVHDLIHGGITPMPEPGAKCKHCSLLEQCMPDVIAHGRSAKSYLQKLFHDLQEDSF
>NC_009337.1|WP_011890538.1|1458367_1459216_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MDAIKKRYDFVLLFDVQDGNPNGDPDAGNLPRIDAETGMGLVSDVCLKRKVRNYVQLAGQEIFIKEKGVLNTLIAESHEQPEVKSKTKGDKTEAARSWMCSKYYDIRTFGAVMSTGENAGQVRGPVQITFARSVEPVVALEHSITRMAVATEAEAEKQDGGNRTMGRKYTIPYGLYLAHGFVSANLANQTGFSEKDLQLFWDALLNMFEHDRSAARGMMSTRGLYIFEHNSALGNAPAHSLFERISVSRKNPASGPARSFAEYSIDINQANLEPVSLIKKLG
>NC_009337.1|WP_011890537.1|1456625_1458341_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MILQALNDYYQRKAADSLSGIAPEGFEWKEIPFIVVIDQKGTFVTIEDTREGDGKKKTAKRFLVPAAEKRTVGIKANLLWDNAEYTLGANPRNRADVHERKSAFIHRLRSEFANDEAEKKVEPLIRFLENEPLAKIESATIDASLWQDLFEKNANVIFRIAEAPEPTIIDELRPYIAAPIEGDGGICLVSGTQGAISRLHASIKGIRGAQSSGAALVSFNLPPFQSYGKTQNYNAPVSESAAFAYTTALNTLLGKESKNKLTIGDTATTVFWSEKSTAFETDFAAFFSFPPKDDPDADVRAVKKLYDGIYTGNNTTDSETDFYVLGLAPNAARISIRFWQKGTVKSLSQNIRKHFDDLEIIRSKNDKNHFALFWILSAMAQENKVDNIPPNLAGQIINAVLNGTQYPTTMHHQVIRRIRATQNVTRLQAAILKAYLNRFHRIHSTNEKEITVTLDMENNSPGYRLGRLFAILEKIQEEANPGINATIRDRFYGAASSTPVTVFPQLLKLKNHHLAKLSNTGRKVNFERMLAEVFSGITTEMPAHLAMGDQARFAIGYYHQRQALFESKTQS
>NC_009337.1|WP_011890536.1|1455918_1456629_+|type-I-C-CRISPR-associated-protein-Cas5
MDYHDKTFCLEVEGDYACFTRPEMKVERVSYDVITPSAARAIFEAIFWKPAIHWKITKIEVLKPIKWISFRRNEVGAVASPQSNGIIIEDSRQQRAGLFLRDVAYRLHAELVFIPASKRTEAKKAAKKTLIDDAEIAAAGKDENPAKYQGMFERRARKGQCFNQPYLGCREFSCNFRLVDNADHERAPILETRDLGFMLYDLDFKNPESPSPAFYRPQIINGIIDVPSWDSEEVKK
>NC_009337.1|WP_011890535.1|1453898_1455896_+|CRISPR-associated-helicase-Cas3'
MGKIDHSSAGALHAVNKNGRVGRILAYLIAGHHAGLPNWTYEPHGGGALSDRLSTIENLYAALEGKPPEELLAKQLPTSIPCGSGFRDNYEAVHLWVRMLYSCLVDADFLDTESFMAPEKTKERHQEWTLDKLKPLFDKHIDQLQQDANATPVNTNRKAILEECKNKASLAPGVFSLTVPTGGGKTLSSMAFALEHAIKYKKKRVIIAIPYTSIIEQTAAIFRKIFGSDAVLEHHSNLDPDRETQSARLSSENWDAPIIVTTNVQLFESLFAARSSSCRKLHNLVNSVIILDEAQTLPTGFLQPILSSLKVLTEYFKASLLLCTATQPILTERIGSDDNILNGFKAGSVREIISNPNTLFEIFQRVKVYGPKSREKLQWEEVKDQLCQHPQVLCIVNTRKDCSELHQLMPEGTVHLSALMCPEHRSEVIAAVKEQLMTNQPIRVISTQLLEAGVDIDFPVVYRAFSGLDSIAQAAGRCNREGLLDYGHVTVFNPPTPSPKGIMLKAEQAAQEVFNSNPKLAASLMPGAFQCYFRAYFNSLNNFDEQSIMDLLAGTDAREFKLQFRTAAQRFKLINNAHQHGVIVKYQSQHHDSTQLIKQLRYAGPSRYLMRRLQRFSVNVYQNDLQEMQRNGVVENIEGLWVQTAETLYNKVFGLDVKAGVNLYW
>NC_009337.1|WP_011890534.1|1453670_1453898_+|CRISPR-associated-endonuclease-Cas3''
MKPVAHLRQLEDLRWEEHLLLNHLTHVADMAAEFAAEFDNADWLRIAGSWHDLGKYNPLWQEYIRNNNGNYTEEE
>NC_009337.1|WP_011890533.1|1452046_1453159_-|DegT/DnrJ/EryC1/StrS-family-aminotransferase
MQFIDLITQKDRIRGAVMARLESIVDRAQFIMGAEVAELESQLAAFAGTRHCLSCSSGTDALLIALMAKGIGPGDAVLTTPFTFVATAEVVSLTGATPVFVDIDPVSFNIDPDGIAGAVKEAEAKGLKPKALIPVDLFGLPADYDRLESVARNHGLWILEDACQGFGGALNGRKAGSFGLVGATSFFPAKPLGCWGDGGAIFTDDDELAELMISVRVHGGGADKYSNVRIGINGRLDAMQAAVLLEKLTIFDEELLLRDRVANAYSKRLAGRVQVPVVPEGYSSAWAQYSVLASDSAEREQLMAALQKEGIPSVIYYKIPLHLQGAYADLGYCAGDFPITEDISSRIFSLPMHPYLKESEIEQVCSALLA
>NC_009337.1|WP_011890544.1|1463993_1465424_+|UDP-N-acetylmuramate--alanine-ligase
MSSLYFIGIGGTAMASVAVALSHLGHAITGSDTGLYPPMSTYLDEHHIRYFSGFSADNLQSVKPDMVVVGNAVSRGNEELEYALNEKMELVAMPDLVRRELIGKNTSIVVAGTHGKTTTTSIVAWLLESGGLRPGFLVGGIPENFGIGCRPSGRSDEGFFVSEGDEYDTAFFDKRSKFMLYRPDIAIINNIEFDHADIFSSLEEIKRSFRLLVNLIPSNGALIVNGDDPVAMEVSSKALCRVETFGLTDGCDWTAQNIRVEENGSSFDLYYKGGFERRFNAPLFGSYNILNTLASIAVATLSGMTLDMTAEGLREFLRPKRRMETVGTYEGNITVIEDFAHHPTAIRVTLEAIKERWPERRIITCFEARSNTTTRNIFQKELAECFGPADIVVLGKVHRPERYGPEGSLDTARLKKELEEQGKTVFLGGSDPKNYPADIVGFLESCRKKDDVVLMLTNGSFAGLKTALTESFQKKR
>NC_009337.1|WP_011890545.1|1465550_1466555_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MTKVKVGINGFGRIGRLVFRQAMDNPKFEIVAINDLCDPKTLAHLLKYDSTHKKFNGEVSVEDGNIVVNGKTITICAERDPANLPWKALGCDLVVESTGIFTSREAASKHIAAGAKKVIISAPAKDKIDATIVLGVNENLITGNEQIISNASCTTNCLAPMVKVLEDSFGLEKGFMTTIHAYTNDQNILDLPHKDLRRARSAGVSMIPTSTGAAKAIGEVIPELAGKLDGFAVRVPVPDGSMTDLTAILKKPATKEEINAAMKAAADGPMKGYLEYCTDPIVSQDIVGNPHSSIFDSLLTMSSGTMVKTVSWYDNELGYSTRVVDLLEIYSNFV
>NC_009337.1|WP_011890546.1|1466723_1467194_+|hypothetical-protein
MKAIILYDSRSEGGSTDRLVDAIGQKLAGKGMDVEKARCRAQADYSFISEFDLVIMGAPVYYLMVSSQLLGALIQSNLSNMLKNKNTALFLACGSPQPMAELLYMPQMKMNLQGSRILAEKVFAPAETSDMEVIGEYVDTIYAEWLKEEERRGKRK
>NC_009337.1|WP_011890547.1|1467264_1468455_-|molecular-chaperone-DnaJ
MKKDYYEILGVGRSADKDEIKKAYRKLALKYHPDKNPDNKDAEDHFKEVNEAYEVLSNDDKRRRYDQFGHAGVGSSAASGGGAGAYGAGGADFSDIFSAFNDMFGGGGGGRGRGGFEDAFGGGQRRSRASAGIQGTDLKIRLKLSLEEIAKGVEKTLKIKKQVPCKECNGSGSKTGATETCPTCHGTGEVRQASKTMFGQFVNIAACPTCGGEGRIVKDRCPACYGEGIKQGEVTVKVTVPAGVQDNNYLTLRGQGNSGPRGGASGDLIVVIEEKPHEFFVRNGDDVIYSLAVSFPDLVLGTKVEVPTLDGAIKMTIPPSTQPETMLRIPGHGIGHLRGSGKGDQYVRVNVFVPKDLSATDKELLKGLRKSPGISPEAHGTGTEKSFFEKMKDIIG
>NC_009337.1|WP_011890548.1|1468478_1469063_-|nucleotide-exchange-factor-GrpE
MMKHRDKPMPENEEPLQEQEGTLHAEPAEPQPQKEDRVAELEAALTAEKEQSGKLRDEVLRRAAEFENFRKQKEREAVQSSLRAKETILRELLPVLDDVERVLANAPEPEAIPVAAKPFIEGVELMKKNLDRWLEEKGVKPIEAIGLKLDVDFHEAISQIEHPEAEPDTIVEQYQTGYLLGDRVIRHAKVIVSR
>NC_009337.1|WP_011890549.1|1469081_1470155_-|heat-inducible-transcription-repressor-HrcA
MGSRELSLRERQVLGIIIQSYVVTAAPVGSRYIARNYSLGLSDATIRNVMADLEDEGYIHQPHTSAGRIPTDLGYRYYVDLIMKVQRIDEDEKRRMETDYGQIAMEHPGTSRDVLLSAAKVLGCISRQLSVVLSPTLSDAVFERLDMVLLSSTRMMVILSIHSLFVKTIVMELPLEVSRKMIEEVSNVINERLAGLTLSEIRRSIAHRLAGSHGDGALKDLIVRSAGSLFDESPIFERLYISGTEYIVDQPEFKQPERVRELITMIEDKFSVARLVEKSGHMSEALRPSDMDVTISIGSENSTREAEDLTIVSTPYYAGNMVGRLGILGPKRMDYEHAVRVLNYMADSLTATLTDAN
>NC_009337.1|WP_041470197.1|1470290_1471169_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase
MEQVREWQVVDLLKTTEEFFSSKGVDEARIGAEMLLSQVLGLKRIELYLNYQRPVYPDELERFRRLCRQRLEGRPVQYIAGEQFFYGLQFHVDERVLIPRPETELLVEHALGFLENTQSARVMDIGTGSGCIAVTMALRNASLVLDALDCSVEALAVARGNALAHKVQDRVRFHEADIFRDSFTAPFSAGTYSLIVSNPPYIPDAEWELLQREVREYEPRLALTTPTGMECYRAIAGHAGELLKPEGVLCFEVHAEGAAAVGAIMDSSGFSAITVTKDYSGLDRIVSGRLQA
>NC_009337.1|WP_041470198.1|1471377_1472118_+|DUF4412-domain-containing-protein
MKKAAILLILLLFSIPGPSTKAAEKFSGVMEMMLTMPSGKGELTFSFGREAQRMDMFLQMDNIPAPVRSTIITRAAEPDQATLLNHDTRSWASLNLKNAAEEAILLDFDSNYTLEKLGTVKLHGYSCQLVRLTSRTEKLELWLTRDLGSFTSFSLLQRQNPHFSNSALSKKLAAAGVDGFPVKTLQHSQNGTYTMELVEAWPKSVPDSQFRVPANYTRISANTPKISKSQKEHLKNLMEKMKKFEQ
>NC_009337.1|WP_011890552.1|1472169_1473615_+|proline--tRNA-ligase
MADKITSREADYSQWYIDLVRSAKLADYSDVRGCMVIRPNGYAVWEKMQAALDRMFKETGHVNAYFPLFIPESFIAKEAEHIEGFAPECAVVTHGGGEELAEKLYVRPTSETIIWSSYKKWIQSYRDLPLLINQWANVVRWEMRTRLFLRTTEFLWQEGHTAHATPEESQEEVMRMIRVYKTFAEEYMAMPVIMGRKTDSEKFAGADETYCIEAMMQDGKALQAGTSHNLGQNFAKAFDCQFQTKEGVLDYVWATSWGVSTRLIGALIMAHSDDRGLVLPPKLATRQVVIIPILRGDKAAVLAKAESMAAELKENGIPAFVDDSEQNSPGWKFAEYELQGIPVRIEVGPRDIDKGVCIAARRDTLEKTELQLDATLAVQVSGMLSAMQADMFQKALRFREENTREVTDYETFKSAVEEGFVIAHWDGTAETEEKIKEETRATIRVLPEESDYREHYHMDEPGVCIFSGKPSSQKVVFAKAY
>NC_009337.1|WP_011890553.1|1473672_1474263_-|peroxiredoxin
MSVLVGRKAPEFNVEAVVGGSQFVDSCKLSDFRGQYVVLFFYPLDFTFVCPTELHAFQEKLEEFKKRNVEVLGCSVDSKFSHLAWLNTPHNRGGIQGVTYTLLSDLNKTVSADYDVLAEGAGVALRGLFLIDCEGVVRHQVVNDLGLGRNVDEVLRMVDALQFTEQFGEVCPANWNKGDKAMKPTDEGLKDFFKND

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_009337_2	2.11\|1463595\|33\|NC_009337\|PILER-CR,CRISPRCasFinder,CRT	1463595-1463627	33	NZ_CP037432	Lactobacillus plantarum strain EM plasmid pEM3, complete sequence	46002-46034	5	0.848
NC_009337_2	2.2\|1463006\|33\|NC_009337\|PILER-CR,CRISPRCasFinder,CRT	1463006-1463038	33	NC_020062	Rhizobium tropici CIAT 899 plasmid pRtrCIAT899c, complete sequence	1275649-1275681	8	0.758
NC_009337_2	2.12\|1463660\|33\|NC_009337\|PILER-CR,CRISPRCasFinder,CRT	1463660-1463692	33	MT002875	Pseudoalteromonas phage AL, complete genome	14995-15027	8	0.758
NC_009337_2	2.1\|1462940\|34\|NC_009337\|PILER-CR,CRISPRCasFinder,CRT	1462940-1462973	34	NZ_CP049251	Rhizobium rhizoryzae strain DSM 29514 plasmid unnamed4, complete sequence	96279-96312	11	0.676

1. spacer 2.11|1463595|33|NC_009337|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP037432 (Lactobacillus plantarum strain EM plasmid pEM3, complete sequence) position: , mismatch: 5, identity: 0.848

---aaagccgtcacttgataaagaaccgtcctcttt	CRISPR spacer
tcgaaa---gtcacttgataaagcaccgtcgtcttt	Protospacer
   ***   ************** ****** *****

2. spacer 2.2|1463006|33|NC_009337|PILER-CR,CRISPRCasFinder,CRT matches to NC_020062 (Rhizobium tropici CIAT 899 plasmid pRtrCIAT899c, complete sequence) position: , mismatch: 8, identity: 0.758

cgtgaatctgctggcgggtatactgacggcgcg	CRISPR spacer
catgaacctgctggcgggtatcctgaccatggt	Protospacer
*.****.************** ***** ..*

3. spacer 2.12|1463660|33|NC_009337|PILER-CR,CRISPRCasFinder,CRT matches to MT002875 (Pseudoalteromonas phage AL, complete genome) position: , mismatch: 8, identity: 0.758

atagtc--tttgaccgaaccaaaaagctggatgga	CRISPR spacer
--ggtcaaattgacccaaccaaaaagcttgatgag	Protospacer
  .***   ****** ************ ****..

4. spacer 2.1|1462940|34|NC_009337|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049251 (Rhizobium rhizoryzae strain DSM 29514 plasmid unnamed4, complete sequence) position: , mismatch: 11, identity: 0.676

ttgttgtcgataagccctttgacgatgccgagcc	CRISPR spacer
ggcctccacataagccctttgaccttgccgagca	Protospacer
   .* .  **************  ********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

96402 : 154611

Leptospira_phage(20.0%)

integrase,protease,transposase

attL 111480:111494|attR 132548:132562

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011889339.1\|96402_97389_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_011889340.1\|98044_98659_-	hypothetical protein	NA	NA	NA	NA
WP_011889341.1\|99163_99832_-	HNH endonuclease	NA	NA	NA	NA
WP_081424449.1\|100652_100865_+\|transposase	transposase	S5WIU1	Leptospira_phage	6.2e-11	50.0
WP_011889342.1\|100914_102894_-	DUF262 domain-containing protein	NA	NA	NA	NA
WP_041469954.1\|102877_104281_-	DUF262 domain-containing protein	NA	NA	NA	NA
WP_011889344.1\|104369_105395_-	WYL domain-containing transcriptional regulator	NA	NA	NA	NA
WP_011889345.1\|105502_106048_-	hypothetical protein	NA	NA	NA	NA
WP_011889347.1\|106496_107591_+	WYL domain-containing protein	NA	NA	NA	NA
WP_011889348.1\|107698_108136_+	hypothetical protein	NA	NA	NA	NA
WP_155811630.1\|108125_108275_+	hypothetical protein	NA	NA	NA	NA
WP_011889349.1\|108297_109245_+	ADP-ribosylglycohydrolase family protein	M1HKZ0	Acanthocystis_turfacea_Chlorella_virus	1.2e-24	26.5
WP_011889350.1\|109285_109975_+	hypothetical protein	NA	NA	NA	NA
WP_041469662.1\|109983_110232_-	hypothetical protein	NA	NA	NA	NA
WP_011889351.1\|110384_111266_-	TIGR02452 family protein	G3MBH6	Bacillus_virus	7.5e-34	36.8
WP_155811631.1\|111347_111521_+	hypothetical protein	NA	NA	NA	NA
111480:111494	attL	NA	NA	NA	NA
WP_011889352.1\|112111_117964_+	DUF3320 domain-containing protein	NA	NA	NA	NA
WP_155811670.1\|118909_119389_+	hypothetical protein	NA	NA	NA	NA
WP_011889355.1\|120505_121198_+	hypothetical protein	NA	NA	NA	NA
WP_011889356.1\|121240_122752_+	sel1 repeat family protein	NA	NA	NA	NA
WP_041469666.1\|122876_123299_+	hypothetical protein	NA	NA	NA	NA
WP_011889358.1\|123943_124405_+	hypothetical protein	NA	NA	NA	NA
WP_155811632.1\|124614_124785_+	hypothetical protein	NA	NA	NA	NA
WP_011889360.1\|124785_125316_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_011889361.1\|125509_126658_+	hypothetical protein	NA	NA	NA	NA
WP_011358431.1\|128281_128566_-	thioredoxin family protein	NA	NA	NA	NA
WP_011358432.1\|128657_128993_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011889363.1\|129317_130175_+	ModD protein	NA	NA	NA	NA
WP_011358434.1\|130187_130961_+	molybdate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_011889364.1\|130974_131661_+	molybdate ABC transporter permease subunit	NA	NA	NA	NA
WP_011358436.1\|131657_132713_+	molybdenum ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	3.8e-16	30.9
132548:132562	attR	NA	NA	NA	NA
WP_155811633.1\|132802_133916_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.3e-42	39.2
WP_011889367.1\|133994_134732_+\|transposase	transposase	NA	NA	NA	NA
WP_041469669.1\|134896_135280_+	hypothetical protein	NA	NA	NA	NA
WP_155811634.1\|135664_136153_+	hypothetical protein	NA	NA	NA	NA
WP_011889369.1\|136202_136577_+	hypothetical protein	NA	NA	NA	NA
WP_041469971.1\|136615_137065_+	5'-3'-deoxyribonucleotidase	I6X231	Vibriophage	1.1e-44	57.9
WP_011889371.1\|137154_137760_+	hypothetical protein	NA	NA	NA	NA
WP_011889372.1\|137866_138271_-	PEGA domain-containing protein	NA	NA	NA	NA
WP_011889373.1\|138906_139491_-	3'-5' exonuclease	NA	NA	NA	NA
WP_011889374.1\|139522_140155_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_041469976.1\|140313_140916_+	VWA domain-containing protein	A0A0P0YMY2	Yellowstone_lake_phycodnavirus	3.3e-25	39.8
WP_011889376.1\|141052_141409_+	DUF3127 domain-containing protein	NA	NA	NA	NA
WP_049752382.1\|141597_142419_+	hypothetical protein	NA	NA	NA	NA
WP_011889378.1\|142465_143311_+	DUF4412 domain-containing protein	NA	NA	NA	NA
WP_011889379.1\|143341_143818_-	hypothetical protein	NA	NA	NA	NA
WP_011889380.1\|144023_144212_+	hypothetical protein	NA	NA	NA	NA
WP_011889381.1\|144217_144673_+	translesion error-prone DNA polymerase V autoproteolytic subunit	A0A1W6JNS2	Morganella_phage	6.4e-29	47.6
WP_011889382.1\|144684_145950_+	Y-family DNA polymerase	I6RSM4	Salmonella_phage	9.6e-91	45.0
WP_011889383.1\|146087_147452_-	hypothetical protein	NA	NA	NA	NA
WP_011889384.1\|147836_149063_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011889385.1\|149243_150698_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011889386.1\|150752_150911_+	hypothetical protein	NA	NA	NA	NA
WP_011889387.1\|151012_151549_-	nitroreductase	NA	NA	NA	NA
WP_011889388.1\|151545_152157_-	DUF1997 domain-containing protein	NA	NA	NA	NA
WP_011889389.1\|152207_153281_-	peptide chain release factor 1	A0A2I2MPK0	Mycobacterium_phage	2.7e-09	47.7
WP_011889390.1\|153297_154611_-\|protease	RIP metalloprotease RseP	NA	NA	NA	NA

DBSCAN-SWA_2

547010 : 556603

Enterobacteria_phage(42.86%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011889718.1\|547010_547889_+	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	9.0e-104	61.8
WP_011889719.1\|547949_548534_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	3.0e-47	57.8
WP_011889720.1\|548530_549391_+	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	6.4e-38	37.5
WP_011889721.1\|549403_550456_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	7.5e-89	48.8
WP_011889722.1\|550474_551443_+	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	1.5e-43	35.3
WP_011889723.1\|551439_552855_+	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	5.0e-56	30.8
WP_011889724.1\|552954_553182_+	hypothetical protein	NA	NA	NA	NA
WP_041470035.1\|553351_556603_+\|tRNA	isoleucine--tRNA ligase	A0A2I2L3Y0	Orpheovirus	1.5e-167	32.8

DBSCAN-SWA_3

708657 : 764859

Escherichia_phage(11.76%)

integrase,transposase

attL 715385:715405|attR 766860:766880

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011889858.1\|708657_710607_-\|integrase	tyrosine-type recombinase/integrase	A0A2I7QY74	Vibrio_phage	4.7e-12	25.1
WP_011889859.1\|710853_711672_+	hypothetical protein	NA	NA	NA	NA
WP_011889860.1\|711668_712286_+	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_011889861.1\|712511_712922_+	hypothetical protein	NA	NA	NA	NA
WP_011358595.1\|713072_713312_+	hypothetical protein	NA	NA	NA	NA
WP_011889862.1\|713823_715212_+	ATP-binding protein	NA	NA	NA	NA
715385:715405	attL	NA	NA	NA	NA
WP_041469732.1\|715490_715814_+	hypothetical protein	NA	NA	NA	NA
WP_041469734.1\|715810_716773_+	GDP-L-fucose synthase	M1HWW2	Paramecium_bursaria_Chlorella_virus	4.7e-90	52.2
WP_011889864.1\|716785_717901_+	GDP-mannose 4,6-dehydratase	M4QRT5	Synechococcus_phage	5.6e-135	67.2
WP_155811677.1\|718022_719726_+	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	1.3e-21	24.8
WP_011889866.1\|720062_721283_-\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_041469736.1\|721519_722239_+	hypothetical protein	F2Y1U6	Organic_Lake_phycodnavirus	2.3e-09	32.1
WP_155811647.1\|722413_723169_+	hypothetical protein	NA	NA	NA	NA
WP_041469737.1\|723193_723688_+	hypothetical protein	NA	NA	NA	NA
WP_081424425.1\|723654_723948_+	FkbM family methyltransferase	NA	NA	NA	NA
WP_011889869.1\|724015_725242_-\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_081424426.1\|725314_725851_+	DUF268 domain-containing protein	NA	NA	NA	NA
WP_011889870.1\|726095_726821_+	FkbM family methyltransferase	NA	NA	NA	NA
WP_011889871.1\|726828_727686_+	alpha-1,2-fucosyltransferase	NA	NA	NA	NA
WP_011889872.1\|727682_728600_+	hypothetical protein	NA	NA	NA	NA
WP_049752398.1\|728596_729112_+	hypothetical protein	NA	NA	NA	NA
WP_049752400.1\|729095_729578_+	hypothetical protein	NA	NA	NA	NA
WP_081424427.1\|729472_731158_+	hypothetical protein	NA	NA	NA	NA
WP_011889874.1\|731173_732121_+	SDR family oxidoreductase	A0A2K9KZK0	Tupanvirus	1.5e-88	49.5
WP_011889875.1\|732122_733670_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_011889876.1\|733713_734622_+	sulfate adenylyltransferase subunit CysD	NA	NA	NA	NA
WP_011889877.1\|734621_736541_+	sulfate adenylyltransferase subunit CysN	A0A1V0SGC3	Hokovirus	4.3e-34	25.9
WP_041470068.1\|736549_737341_+	3'(2'),5'-bisphosphate nucleotidase CysQ	NA	NA	NA	NA
WP_011889879.1\|737337_739119_+	SLC13 family permease	NA	NA	NA	NA
WP_155811648.1\|739127_739664_+	hypothetical protein	NA	NA	NA	NA
WP_011889881.1\|739676_740270_+	adenylyl-sulfate kinase	A0A1B0XTK9	Freshwater_phage	7.6e-06	33.0
WP_155811649.1\|740610_740970_+	hypothetical protein	NA	NA	NA	NA
WP_011889882.1\|741131_742340_+	AAA family ATPase	A0A077SLJ9	Escherichia_phage	4.2e-19	25.4
WP_155811678.1\|742351_742957_+	DUF4276 family protein	NA	NA	NA	NA
WP_041469745.1\|743071_743671_+	hypothetical protein	NA	NA	NA	NA
WP_081424428.1\|743919_744897_+	glycosyltransferase	A0A1V0SAH6	Catovirus	4.9e-10	24.7
WP_011889887.1\|745644_747144_+	hypothetical protein	NA	NA	NA	NA
WP_011889888.1\|747155_748304_+	O-antigen polymerase	NA	NA	NA	NA
WP_081424429.1\|748269_749088_+	glycosyltransferase family 2 protein	A0A218M8U1	Mycobacterium_phage	5.2e-05	35.2
WP_011889890.1\|749241_749727_+\|transposase	transposase	NA	NA	NA	NA
WP_011889891.1\|749756_750623_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_081424430.1\|750789_750963_+	hypothetical protein	A0A2H4UUT1	Bodo_saltans_virus	7.8e-12	54.4
WP_011889892.1\|750975_751827_+	glycosyltransferase	NA	NA	NA	NA
WP_041470078.1\|751936_752929_+	NAD-dependent epimerase/dehydratase family protein	A0A0K1L6Z1	Scale_drop_disease_virus	5.2e-07	28.6
WP_011889894.1\|752977_753472_+	WbuC family cupin fold metalloprotein	NA	NA	NA	NA
WP_155811679.1\|753624_754158_+	hypothetical protein	NA	NA	NA	NA
WP_011889896.1\|755053_755389_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_011358561.1\|756862_757201_-	hypothetical protein	NA	NA	NA	NA
WP_011889897.1\|757212_757560_-	addiction module protein	A0A141GEX6	Brucella_phage	2.7e-11	37.2
WP_081424431.1\|757611_758079_+	hypothetical protein	B0FIJ9	Escherichia_phage	1.9e-07	37.3
WP_011889899.1\|758322_758955_-	RES family NAD+ phosphorylase	NA	NA	NA	NA
WP_011889900.1\|758986_759367_-	DUF2384 domain-containing protein	NA	NA	NA	NA
WP_011889901.1\|759957_760914_-	HipA domain-containing protein	NA	NA	NA	NA
WP_011889902.1\|760917_761241_-	phosphatidylinositol kinase	NA	NA	NA	NA
WP_011889903.1\|761244_761451_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_041469752.1\|761778_761973_-	hypothetical protein	NA	NA	NA	NA
WP_011889904.1\|761973_762267_-	putative addiction module antidote protein	A4JWV1	Burkholderia_virus	3.0e-11	45.2
WP_011889905.1\|762263_762569_-	type II toxin-antitoxin system RelE/ParE family toxin	A4JWV2	Burkholderia_virus	2.2e-17	45.7
WP_011889906.1\|763009_764518_-	Fic family protein	NA	NA	NA	NA
WP_011889907.1\|764568_764859_-\|transposase	transposase	NA	NA	NA	NA
766860:766880	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_009337

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection