CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Prophage number
NC_011986	Agrobacterium vitis S4 plasmid pAtS4a, complete sequence	0 crisprs	NA	1
NC_011984	Agrobacterium vitis S4 plasmid pAtS4c, complete sequence	0 crisprs	NA	1
NC_011988	Agrobacterium vitis S4 chromosome 2, complete sequence	0 crisprs	csa3	1
NC_011982	Agrobacterium vitis S4 plasmid pTiS4, complete sequence	0 crisprs	csa3	2
NC_011989	Agrobacterium vitis S4 chromosome 1, complete sequence	2 crisprs	cas3,csa3,DEDDh,WYL	8
NC_011991	Agrobacterium vitis S4 plasmid pAtS4b, complete sequence	0 crisprs	NA	0
NC_011981	Agrobacterium vitis S4 plasmid pAtS4e, complete sequence	0 crisprs	NA	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

29462 : 38681

Acidithiobacillus_phage(33.33%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012653034.1\|29462_31016_+\|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	1.6e-103	42.4
WP_012653035.1\|31028_31805_+	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	1.1e-60	47.1
WP_085946666.1\|32042_33273_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	6.3e-103	66.2
WP_080517094.1\|33596_33902_+	hypothetical protein	NA	NA	NA	NA
WP_012653038.1\|33820_35170_-	adenylate/guanylate cyclase domain-containing protein	A0A1B1IWY2	uncultured_Mediterranean_phage	2.9e-16	24.7
WP_012653039.1\|35255_35540_-	copper-binding protein	NA	NA	NA	NA
WP_012653040.1\|35562_36042_-	cupredoxin domain-containing protein	NA	NA	NA	NA
WP_012653041.1\|36181_36451_-	hypothetical protein	NA	NA	NA	NA
WP_012653042.1\|36643_37321_+	response regulator	W8CYM9	Bacillus_phage	7.6e-26	32.7
WP_012653043.1\|37307_38681_+	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	1.9e-15	23.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_011988

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1167799 : 1206354

Sinorhizobium_phage(29.63%)

tail,portal,integrase,protease,terminase,head,capsid

attL 1162936:1162952|attR 1178509:1178525

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1162936:1162952	attL	NA	NA	NA	NA
WP_071207950.1\|1167799_1168843_-\|integrase	tyrosine-type recombinase/integrase	A0A291AUF0	Sinorhizobium_phage	1.1e-52	38.0
WP_012654387.1\|1168846_1169101_-	hypothetical protein	NA	NA	NA	NA
WP_041698674.1\|1169163_1169670_-	hypothetical protein	NA	NA	NA	NA
WP_041698677.1\|1169681_1170140_-	hypothetical protein	NA	NA	NA	NA
WP_012654388.1\|1170140_1170488_-	HNH endonuclease	A0A291AUJ4	Sinorhizobium_phage	1.0e-39	72.6
WP_041698680.1\|1170480_1170804_-	hypothetical protein	NA	NA	NA	NA
WP_012654389.1\|1170803_1171625_-	hypothetical protein	NA	NA	NA	NA
WP_012654390.1\|1171621_1172365_-	hypothetical protein	B4UTT6	Rhizobium_phage	3.5e-48	53.4
WP_012654391.1\|1172346_1172892_-	hypothetical protein	A0A068C9C1	Rhizobium_phage	1.2e-16	33.7
WP_012654392.1\|1172884_1174021_-	DNA polymerase III subunit beta	B4UTW9	Rhizobium_phage	8.5e-38	30.7
WP_041698684.1\|1174013_1174220_-	hypothetical protein	NA	NA	NA	NA
WP_012654393.1\|1174221_1174587_-	hypothetical protein	NA	NA	NA	NA
WP_156753187.1\|1174583_1174745_-	hypothetical protein	NA	NA	NA	NA
WP_012654394.1\|1174737_1175061_-	hypothetical protein	NA	NA	NA	NA
WP_156753186.1\|1175057_1175231_-	hypothetical protein	NA	NA	NA	NA
WP_012654395.1\|1175227_1175548_-	hypothetical protein	NA	NA	NA	NA
WP_139192347.1\|1175544_1175745_-	hypothetical protein	NA	NA	NA	NA
WP_156753185.1\|1175752_1175911_-	hypothetical protein	NA	NA	NA	NA
WP_012654396.1\|1175979_1176852_-	ParB N-terminal domain-containing protein	A0A0U2C144	Paracoccus_phage	4.4e-34	47.7
WP_012654397.1\|1176916_1177267_-	hypothetical protein	NA	NA	NA	NA
WP_012654398.1\|1177458_1178076_+	hypothetical protein	NA	NA	NA	NA
WP_012654399.1\|1178082_1178481_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012654400.1\|1179027_1179360_-	helix-turn-helix transcriptional regulator	A0A141GF24	Brucella_phage	7.7e-08	42.4
1178509:1178525	attR	NA	NA	NA	NA
WP_012654401.1\|1179432_1179627_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012654403.1\|1180096_1180555_+	hypothetical protein	A0A291AUS4	Sinorhizobium_phage	3.5e-27	51.0
WP_041698695.1\|1180558_1180744_+	hypothetical protein	NA	NA	NA	NA
WP_139192348.1\|1180736_1180970_+	hypothetical protein	NA	NA	NA	NA
WP_041698697.1\|1180966_1181155_+	hypothetical protein	NA	NA	NA	NA
WP_012654404.1\|1181420_1183196_+	hypothetical protein	A0A291AUK6	Sinorhizobium_phage	2.2e-141	57.2
WP_041698702.1\|1183195_1183483_+	hypothetical protein	A0A1V0EES3	Caulobacter_phage	2.8e-06	46.6
WP_071207954.1\|1183475_1183769_+	hypothetical protein	NA	NA	NA	NA
WP_012654406.1\|1183765_1184938_+	DNA cytosine methyltransferase	Q6JIG4	Burkholderia_virus	3.8e-33	31.7
WP_012654407.1\|1184934_1186230_+	helix-turn-helix domain-containing protein	A0A068CE61	Rhizobium_phage	1.3e-53	33.9
WP_049777372.1\|1186216_1186840_+	hypothetical protein	NA	NA	NA	NA
WP_187152407.1\|1187087_1187486_+	HNH endonuclease	C4ML58	Xanthomonas_virus	1.1e-13	46.8
WP_012654409.1\|1187622_1188264_+\|terminase	P27 family phage terminase small subunit	NA	NA	NA	NA
WP_012654410.1\|1188274_1190017_+\|terminase	terminase large subunit	A0A2K5B285	Erysipelothrix_phage	1.6e-80	33.7
WP_012654411.1\|1190016_1191261_+\|portal	phage portal protein	A0A141GEV9	Brucella_phage	4.2e-91	47.9
WP_012654412.1\|1191238_1192093_+\|protease	Clp protease ClpP	A0A141GEW1	Brucella_phage	3.5e-60	45.2
WP_139192525.1\|1192243_1193518_+\|capsid	phage major capsid protein	A0A141GEW2	Brucella_phage	1.6e-80	40.5
WP_012654414.1\|1193570_1194008_+	hypothetical protein	NA	NA	NA	NA
WP_012654415.1\|1194070_1194667_+\|head,tail	phage head-tail connector protein	A0A141GEW4	Brucella_phage	2.9e-29	39.5
WP_012654416.1\|1194666_1194987_+\|head	phage head closure protein	C7BGH2	Burkholderia_phage	7.0e-06	35.0
WP_012654417.1\|1194990_1195437_+	hypothetical protein	A0A0U2C0P4	Paracoccus_phage	8.8e-15	36.1
WP_012654418.1\|1195440_1195836_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_012654419.1\|1195853_1196540_+	hypothetical protein	A0A0H4INV0	Stenotrophomonas_phage	2.7e-07	40.0
WP_012654420.1\|1196547_1196931_+	hypothetical protein	NA	NA	NA	NA
WP_012654421.1\|1196993_1197245_+	hypothetical protein	NA	NA	NA	NA
WP_049777373.1\|1197244_1199635_+\|tail	phage tail tape measure protein	I3NL90	Bifidobacterium_phage	3.3e-31	30.1
WP_012654423.1\|1199634_1200354_+	hypothetical protein	A0A291AUU7	Sinorhizobium_phage	3.4e-48	45.0
WP_012654424.1\|1200356_1200938_+	hypothetical protein	A0A291AUU9	Sinorhizobium_phage	6.2e-61	52.3
WP_041698705.1\|1200934_1201348_+	hypothetical protein	NA	NA	NA	NA
WP_012654426.1\|1201344_1203510_+	hypothetical protein	A0A291AUU6	Sinorhizobium_phage	1.0e-164	46.8
WP_041698707.1\|1203560_1205477_+	hypothetical protein	A0A291AUU8	Sinorhizobium_phage	4.3e-34	45.0
WP_139192505.1\|1205494_1205686_+	hypothetical protein	NA	NA	NA	NA
WP_012654428.1\|1205745_1206354_+	hypothetical protein	R9U4A9	Rhizobium_phage	3.0e-42	45.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NC_011982

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

7356 : 81684

Escherichia_phage(20.0%)

transposase,integrase

attL 77706:77765|attR 82400:83147

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012648915.1\|7356_8493_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_012648916.1\|9561_10257_+	SMC-Scp complex subunit ScpB	NA	NA	NA	NA
WP_041699446.1\|10346_10670_-	hypothetical protein	NA	NA	NA	NA
WP_012648919.1\|11907_12624_+\|transposase	IS6 family transposase	NA	NA	NA	NA
WP_139191542.1\|12778_13006_+	hypothetical protein	NA	NA	NA	NA
WP_012648921.1\|13034_13523_+	hypothetical protein	NA	NA	NA	NA
WP_041699447.1\|13519_13708_+	hypothetical protein	NA	NA	NA	NA
WP_012648922.1\|13817_14705_+	Ku protein	A0A249XRB2	Mycobacterium_phage	5.1e-14	27.3
WP_012648923.1\|14708_15530_+	Ku protein	NA	NA	NA	NA
WP_012648924.1\|15593_18275_-	DNA ligase D	A0A1X9SH33	Bradyrhizobium_phage	6.7e-25	41.6
WP_174083776.1\|18617_19681_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_012648926.1\|19975_20953_+	TIGR03885 family FMN-dependent LLM class oxidoreductase	NA	NA	NA	NA
WP_012648927.1\|21012_22674_+	alpha-amylase family protein	NA	NA	NA	NA
WP_012648935.1\|24041_24758_+\|transposase	IS6 family transposase	NA	NA	NA	NA
WP_012648929.1\|24954_26739_+	PAS domain-containing methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	1.9e-07	30.1
WP_012648930.1\|27092_27371_-	HU family DNA-binding protein	B5TA87	Burkholderia_phage	2.4e-10	42.5
WP_012648931.1\|28127_28448_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_162292250.1\|32037_32232_-	hypothetical protein	NA	NA	NA	NA
WP_012648935.1\|33342_34059_+\|transposase	IS6 family transposase	NA	NA	NA	NA
WP_041699461.1\|34142_34763_-	BA14K family protein	NA	NA	NA	NA
WP_012648937.1\|35379_35595_-	type IV conjugative transfer system coupling protein TraD	NA	NA	NA	NA
WP_012648938.1\|35599_35896_-	TraC family protein	NA	NA	NA	NA
WP_012648940.1\|44011_44956_-	GGDEF domain-containing protein	G3MA91	Bacillus_virus	1.1e-19	33.3
WP_041699550.1\|44952_45375_-	helix-turn-helix transcriptional regulator	Q8W6G2	Sinorhizobium_phage	2.9e-28	51.2
WP_041699462.1\|48130_48883_+\|transposase	IS6 family transposase	A0A077SL39	Escherichia_phage	1.2e-40	43.8
WP_041699553.1\|49975_51226_-	hypothetical protein	NA	NA	NA	NA
WP_041699465.1\|51394_51721_-	XRE family transcriptional regulator	NA	NA	NA	NA
WP_041699467.1\|51717_52077_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_041699469.1\|52836_53013_+	hypothetical protein	NA	NA	NA	NA
WP_041699470.1\|53230_54193_+	DUF3991 and TOPRIM domain-containing protein	NA	NA	NA	NA
WP_012648950.1\|54335_54938_+	DUF1419 domain-containing protein	NA	NA	NA	NA
WP_174083776.1\|56620_57683_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_012648953.1\|61658_64496_-	hypothetical protein	NA	NA	NA	NA
WP_041699472.1\|64492_65242_-	hypothetical protein	NA	NA	NA	NA
WP_012648955.1\|65581_66406_-	isocitrate lyase/phosphoenolpyruvate mutase family protein	NA	NA	NA	NA
WP_012648956.1\|68594_69068_+	hypothetical protein	NA	NA	NA	NA
WP_012648957.1\|69064_69952_+	hypothetical protein	NA	NA	NA	NA
WP_012648959.1\|70698_71298_+	hypothetical protein	NA	NA	NA	NA
WP_012648960.1\|71613_72540_+	DUF1738 domain-containing protein	A0A1V0EEV1	Caulobacter_phage	1.6e-74	48.3
WP_174083776.1\|73594_74658_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_080517078.1\|77553_77721_+	DUF736 family protein	NA	NA	NA	NA
77706:77765	attL	NA	NA	NA	NA
WP_012648963.1\|77848_78151_-	DUF736 domain-containing protein	NA	NA	NA	NA
WP_143050364.1\|78116_78455_-	hypothetical protein	NA	NA	NA	NA
WP_012648964.1\|78539_79766_+\|integrase	tyrosine-type recombinase/integrase	A7XX23	Thermus_virus	6.0e-13	29.1
WP_041699479.1\|79759_80680_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012648966.1\|80676_81684_+\|integrase	tyrosine-type recombinase/integrase	A0A2L1IV36	Escherichia_phage	9.6e-09	29.5
82400:83147	attR	NA	NA	NA	NA

DBSCAN-SWA_2

145480 : 184009

Stx2-converting_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012649016.1\|145480_146581_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_041699590.1\|146743_147133_+\|transposase	IS5/IS1182 family transposase	A0A0N9SHJ4	Paenibacillus_phage	2.6e-10	38.4
WP_158212759.1\|147692_148139_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012649017.1\|148204_150673_-	virA/G regulated protein	NA	NA	NA	NA
WP_041699501.1\|150780_152769_-	type IV secretion system ATPase VirD4	NA	NA	NA	NA
WP_139191409.1\|152829_155160_-	virA/G regulated protein	NA	NA	NA	NA
WP_012649020.1\|155515_156727_-	T-DNA border endonuclease VirD2	NA	NA	NA	NA
WP_012649021.1\|156753_157200_-	T-DNA border endonuclease subunit VirD1	NA	NA	NA	NA
WP_012649022.1\|157456_158152_+	conjugal transfer ATPase VirC1	A0A0A8IL09	Aurantimonas_phage	1.6e-10	29.9
WP_041699509.1\|158154_158763_+	conjugal transfer protein VirC2	NA	NA	NA	NA
WP_012649024.1\|158884_159610_-	response regulator	NA	NA	NA	NA
WP_012649025.1\|159840_160875_-	P-type DNA transfer ATPase VirB11	NA	NA	NA	NA
WP_012649026.1\|160908_162030_-	type IV secretion system protein VirB10	NA	NA	NA	NA
WP_012649027.1\|162029_162908_-	P-type conjugative transfer protein VirB9	NA	NA	NA	NA
WP_012649028.1\|162904_163618_-	type IV secretion system protein VirB8	NA	NA	NA	NA
WP_012649104.1\|163604_163772_-	type IV secretion system lipoprotein VirB7	NA	NA	NA	NA
WP_012649029.1\|163799_164687_-	type IV secretion system protein	NA	NA	NA	NA
WP_012649030.1\|164746_165415_-	pilin minor subunit VirB5	NA	NA	NA	NA
WP_012649031.1\|165442_167812_-	VirB4 family type IV secretion/conjugal transfer ATPase	NA	NA	NA	NA
WP_012649032.1\|167811_168138_-	type IV secretion system protein VirB3	NA	NA	NA	NA
WP_012649033.1\|168134_168500_-	pilin major subunit VirB2	NA	NA	NA	NA
WP_012649034.1\|168515_169232_-	type IV secretion system lytic transglycosylase VirB1	NA	NA	NA	NA
WP_012649035.1\|170523_170877_+	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_012649036.1\|170938_172600_+\|transposase	IS66 family transposase	A0A0P0ZEB3	Stx2-converting_phage	7.7e-72	37.4
WP_041699516.1\|174076_174424_-	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZBY2	Stx2-converting_phage	7.8e-27	54.9
WP_012649039.1\|174420_174783_-	IS66 family insertion sequence hypothetical protein	NA	NA	NA	NA
WP_080517075.1\|174872_175073_-\|transposase	transposase	NA	NA	NA	NA
WP_012649040.1\|175274_177296_-	virA/G regulated protein	NA	NA	NA	NA
WP_012649041.1\|177362_179033_-	type IV secretion system single-stranded DNA binding effector VirE2	NA	NA	NA	NA
WP_012649042.1\|179046_179238_-	type IV secretion system effector chaperone VirE1	NA	NA	NA	NA
WP_041699590.1\|180144_180534_-\|transposase	IS5/IS1182 family transposase	A0A0N9SHJ4	Paenibacillus_phage	2.6e-10	38.4
WP_012649035.1\|181932_182286_+	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_012649036.1\|182347_184009_+\|transposase	IS66 family transposase	A0A0P0ZEB3	Stx2-converting_phage	7.7e-72	37.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

4. NC_011989

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_011989_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011989_1

2483585-2483681

Orphan

Consensus_repeat	Method
CGGAAAACCGCTTCACACTTTTCCTGGAAATGCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_011989_1

>merge|NC_011989|1|2483585-2483681|CRISPRCasFinder
CGGAAAACCGCTTCACACTTTTCCTGGAAATGCTCCAGGTCTTTGCCTCACGCATTTCCGGACGGAAAACCGCTTCACACTTTTCCTGGAAATGCTC

>NC_011989|1|1|2483585-2483681|CRISPRCasFinder
CGGAAAACCGCTTCACACTTTTCCTGGAAATGCTC	CAGGTCTTTGCCTCACGCATTTCCGGA
CGGAAAACCGCTTCACACTTTTCCTGGAAATGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011989.1\|WP_041696828.1\|2493036_2493561_-\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223528
NC_011989.1\|WP_041696822.1\|2484305_2484530_-\|hypothetical-protein	unknown	unknown	unknown
NC_011989.1\|WP_015916572.1\|2492031_2492922_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|272892
NC_011989.1\|WP_015916561.1\|2478216_2481990_-\|methionine-synthase	unknown	unknown	gnl\|CDD\|236539
NC_011989.1\|WP_015916553.1\|2471230_2472289_-\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|235440
NC_011989.1\|WP_015916560.1\|2477564_2478137_-\|hypothetical-protein	unknown	unknown	unknown
NC_011989.1\|WP_015916562.1\|2482248_2483505_+\|AGE-family-epimerase/isomerase	unknown	unknown	gnl\|CDD\|369267
NC_011989.1\|WP_015916569.1\|2489103_2489742_+\|porin-family-protein	unknown	unknown	gnl\|CDD\|226163
NC_011989.1\|WP_015916558.1\|2476185_2476566_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133388
NC_011989.1\|WP_187152357.1\|2472599_2473343_+\|autoinducer-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|99777
NC_011989.1\|WP_015916556.1\|2474402_2475572_+\|acyltransferase	unknown	unknown	gnl\|CDD\|224748
NC_011989.1\|WP_015916565.1\|2484912_2485734_-\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|224442
NC_011989.1\|WP_015916570.1\|2489801_2490548_-\|SIMPL-domain-containing-protein	unknown	unknown	gnl\|CDD\|225516
NC_011989.1\|WP_139190210.1\|2485919_2486348_-\|copper-resistance-protein	unknown	unknown	gnl\|CDD\|226861
NC_011989.1\|WP_015916557.1\|2475616_2476099_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_011989.1\|WP_015916555.1\|2473657_2474062_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_011989.1\|WP_015916568.1\|2487942_2488806_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|183067
NC_011989.1\|WP_041696824.1\|2491005_2491809_-\|hypothetical-protein	unknown	unknown	unknown
NC_011989.1\|WP_041696818.1\|2476644_2477460_+\|aminotransferase-class-IV-family-protein	unknown	unknown	gnl\|CDD\|236438
NC_011989.1\|WP_187152389.1\|2486431_2487787_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|224089

Protein	Function_ID	Function_description	E-value
NC_011989.1\|WP_041696828.1\|2493036_2493561_-\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	4.79581e-06
NC_011989.1\|WP_015916561.1\|2478216_2481990_-\|methionine-synthase	gnl\|CDD\|236539	PRK09490, metH, B12-dependent methionine synthase; Provisional.	0
NC_011989.1\|WP_015916553.1\|2471230_2472289_-\|histidinol-phosphate-transaminase	gnl\|CDD\|235440	PRK05387, PRK05387, histidinol-phosphate aminotransferase; Provisional.	0
NC_011989.1\|WP_015916572.1\|2492031_2492922_+\|hypothetical-protein	gnl\|CDD\|272892	TIGR00075, Hydrogenase_isoenzymes_formation_protein_HypD, hydrogenase expression/formation protein HypD. HypD is involved in the hyp operon which is needed for the activity of the three hydrogenase isoenzymes in Escherichia coli. HypD is one of the genes needed for formation of these enzymes. This protein has been found in gram-negative and gram-positive bacteria and Archaea. [Protein fate, Protein modification and repair].	0.00763418
NC_011989.1\|WP_015916562.1\|2482248_2483505_+\|AGE-family-epimerase/isomerase	gnl\|CDD\|369267	pfam07221, GlcNAc_2-epim, N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase). This family contains a number of eukaryotic and bacterial N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) enzymes (EC:5.3.1.8) approximately 500 residues long. This converts N-acyl-D-glucosamine to N-acyl-D-mannosamine.	3.78267e-128
NC_011989.1\|WP_015916569.1\|2489103_2489742_+\|porin-family-protein	gnl\|CDD\|226163	COG3637, COG3637, Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane].	2.3315e-21
NC_011989.1\|WP_015916558.1\|2476185_2476566_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133388	cd01282, HTH_MerR-like_sg3, Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily. Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 3). Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	3.40483e-39
NC_011989.1\|WP_187152357.1\|2472599_2473343_+\|autoinducer-binding-domain-containing-protein	gnl\|CDD\|99777	cd06170, LuxR_C_like, C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.	6.73717e-22
NC_011989.1\|WP_015916556.1\|2474402_2475572_+\|acyltransferase	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	9.34958e-25
NC_011989.1\|WP_015916565.1\|2484912_2485734_-\|thermonuclease-family-protein	gnl\|CDD\|224442	COG1525, COG1525, Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair].	2.33794e-16
NC_011989.1\|WP_015916570.1\|2489801_2490548_-\|SIMPL-domain-containing-protein	gnl\|CDD\|225516	COG2968, COG2968, Uncharacterized conserved protein [Function unknown].	2.9233e-73
NC_011989.1\|WP_139190210.1\|2485919_2486348_-\|copper-resistance-protein	gnl\|CDD\|226861	COG4454, COG4454, Uncharacterized copper-binding protein [Inorganic ion transport and metabolism].	3.98003e-18
NC_011989.1\|WP_015916557.1\|2475616_2476099_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.54397e-09
NC_011989.1\|WP_015916555.1\|2473657_2474062_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.82795e-15
NC_011989.1\|WP_015916568.1\|2487942_2488806_+\|DMT-family-transporter	gnl\|CDD\|183067	PRK11272, PRK11272, putative DMT superfamily transporter inner membrane protein; Provisional.	5.46501e-08
NC_011989.1\|WP_041696818.1\|2476644_2477460_+\|aminotransferase-class-IV-family-protein	gnl\|CDD\|236438	PRK09266, PRK09266, hypothetical protein; Provisional.	2.06414e-135
NC_011989.1\|WP_187152389.1\|2486431_2487787_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	3.5837e-123

>NC_011989.1|WP_015916562.1|2482248_2483505_+|AGE-family-epimerase/isomerase
MSNVNQGKSLADQWSGRPYHRKWLLDQANGLFDFFQTAAINPKGGFYDLARDGTPLTTDNPVRGIHASARMVHCYAIGDLLGRPGAADVVDHGMRYLWRKHRDEKNGGYVWQLNDDGVADGSKQGYGHAFVLLAASSAKTVGHPLADRLLEDITEVLETKFWEERHGAIAEEFSQDWQPVAGYRGQNSNMHLTEALMAAFEATGEQHYLDKATRIADLIINRRAREEAFRVAEHFDEEWVVDRNYYHPNEMFRPAGTTPGHWLEWARLVLQLWVLTGKQHDWMPEAASGLFYQSMLLGWDRKKGGFYYTLDWDNVPAKTFKLWWPLCEAAGAAHYLNQHQGRDLNEENYRKIWSFIANHTIDKQFGGWHEEMTEDLVPSNSLFPGKGDIYHALQACLIPLFPAEGSLTKVIQEYPLDV
>NC_011989.1|WP_015916561.1|2478216_2481990_-|methionine-synthase
MLDQLFGREGANRDGAEILKALQQAARERILILDGAMGTEIQGLGLDEDDFRGERFIGCACHQKGNNDLLILTQPEAIEDIHFRYAMAGADIVETNTFSSTRIAQADYEMEGAVYDLNKHGAQVVRRALLRAEREDGKRRFVAGAIGPTNRTASISPDVNNPGYRAVSFDDLRLAYGEQIDGLIDGGADLILIETIFDTLNAKAAIFACEERFLAKGIRLPVMISGTITDLSGRTLSGQTPSAFWNSVRHAKPFTIGLNCALGADAMRPHLQELSGLADTFVSAYPNAGLPNEFGQYDQSPEYMAKLVEGFAEEGIVNVVGGCCGSTPAHIQAIAEAVKGKTPRQPVEHRPFMSLSGLEPFVLTKDIPFVNVGERTNVTGSAKFRKLITAGDYNAALVVARDQVENGAQIIDINMDEGLIDSEKAMVEFLNLIAAEPDIARVPVMIDSSKFQIIESGLKCVQGKPIVNSISLKEGEENFVAQAKLIRNYGAAVVVMAFDETGQADTYERKVAICERAYKILTEDAGFSPEDIIFDPNVFAVATGIEEHNNYGVDFIEATRTIRQRMPLVHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNAGQLAVYESIDAELREACEDVVLNRREDGTERLLEIAERYRGTGEAKARVQDMSWRELPVEKRLEHALVNGITEFIDADTEEARQNAARPLHVIEGPLMAGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAVLLPYMEEEKRANGGTGEREAAGKILMATVKGDVHDIGKNIVGVVLACNNYEIIDLGVMVPAAKILEVAIKENVDIIGLSGLITPSLDEMVHVAAEMQRQGFNVPLLIGGATTSRVHTAVKIHPQYQKGQAVYVLDASRAVGVVSSLLSPDTRDTTIETLRTEYAKVADAHARAELEKQRLPISRARANAAKVDWASYKPKKPSFTGIKVFENYDLKELAKYIDWTPFFQTWELKGRYPAILEDEKQGEAARALYADAQAMLAKIIDETWFRPRAVIGFWPANTVGDDIRLFADEERSQELATFFTLRQQLSKRDGRPNVALSDFVAPVDSGVEDYVGGFVVTAGIEEVAISERFERANDDYSSIMVKALADRFAEAFAERMHERVRKEFWGYGADETYTPEELISESYAGIRPAPGYPAQPDHTEKVTLFNLLDATATTGVTLTESYAMWPGSSVSGIYIGHPDSYYFGVAKVERDQVEDYAARKGMEVREIERWLGPVLNYVPKAAVEEDAAA
>NC_011989.1|WP_015916560.1|2477564_2478137_-|hypothetical-protein
MTLIATYLPNYSFREVHSCVIAASTGTVISAAANYSPEADPVFRKMIGLREWPTRFASFLRGKQSQLPPPFGMHNFTLLERRDGAELAYGLVGRFWRPDFGLVPIRDGSAFLRFDTPSVAKLVLGFSAAGQADGMTLLITETRVFCPDRVCWLKFAPYWYVIRPVSGLIRRRILAAMKRASESASPSVII
>NC_011989.1|WP_041696818.1|2476644_2477460_+|aminotransferase-class-IV-family-protein
MSTCFPSKITLNGHAVSADDLAPLAFSGFAHFTAMQVRQGRVQGLELHLERLRLASLAMFGMAMPDEQVRAHLHAVLDGAPNDLSLTATIFSRSGEFTAPAAPDNLAILVRTALPSNGPAGPLRLDVVLHERPLASIKHVGESAKTYYLRKAVERGFDDAAFLDTKGRLSEATIWNLVFWDGEAIVWPRADMLHGVTMGIIRRQLEKLGIPQRQQEVRLEDLKNMTSAALMNSWTPGIAISSIETTNFTQTSTLTELLHRAYQAEPAIAIG
>NC_011989.1|WP_015916558.1|2476185_2476566_-|MerR-family-transcriptional-regulator
MKIGEFARQTGTSIRMLRYYEAEGLLTPTRTASGYRDYGQAEKNVIERIKLLGAAGMTLPVILQFLPCALDARAEFEPCDELRSILRQHVALVDQRVDKLVQSRTLLSELLTTLDEQDPNLVETQA
>NC_011989.1|WP_015916557.1|2475616_2476099_-|GNAT-family-N-acetyltransferase
MLIRPSTSLDAQGMSDALNEIFAAGLRKSAGDPQLVLANYIEHKDRIECSVAQDDEGRIFGFQSLRFATVDNPYGTPEGWGIIGTHISPLAARRGIGSALFRATLQAAKSFPLDNIEAAIGADNEAGLAYYEAMGFRTYRSSEVTICKVYRIEADAHKPV
>NC_011989.1|WP_015916556.1|2474402_2475572_+|acyltransferase
MKSIGSVLDEHRGIGPGFDFLRIFLAVMVLLDHSFLIAEGEKHQFSQPGITVLQAAILPMFFALSGFLITGSAIRLRLKDFLLNRGIRIVPALAVDIVFAALILGPLFTTVSLSAYFQSYEFWAYFANIFGVIHYVLPGVFEHNPFPSTVNGSLWTVPYEIGCYAIMSALIIFGFLKRPMMALVATACVAVIIIALKVENISPSSLGGLFAPESSGYTLLNHFIGLRGLMLYVNFMLGSVFFLFRRFIPKHWVLAAISCIVPIAISFALPDVSGSTLCTIFAPMLVYLTVYVGMVRIPPIPIYHRGDYSYGIYLYGYPFQQALVNLFPKLTSPWLHFAISLPIATVIAMGSWHFIEKPILRLRKKFSFTAQKGEEKEVLPQAAAVTRSA
>NC_011989.1|WP_015916555.1|2473657_2474062_+|helix-turn-helix-transcriptional-regulator
MTLLKKTPDVHDYNILAGERLKSARKNKGMSQADVARKLGVTFQQLHKYEKGINGMSASRLAAAATLLGMDPDFFYTADSAVAPSKDTSSELTDLVKATSRSDALELNTCFASIKNSNTRKIIISIIEQIASAR
>NC_011989.1|WP_187152357.1|2472599_2473343_+|autoinducer-binding-domain-containing-protein
MTKDMTSPNLDKTLSFLSQIKQTDTVKNLVDLTKHATSRYGVKNIVLGFPPEIGMLPSQQMQGILLADWPDEWSHLYFRDNLAFQDPAIRHIVSSEPSFVWSDFSKTLPISRDEKWLMDQAKEFFVSNGFTLPILSLDGRRAGVTFAGSDIDDSPQARTGMALIASLVFARALELYGANQKQTTRLTPREREVIGWIANGKTDWEISVIFGVSEKAVTKHVGNIMMKLGAVSRSHAIAEAFRQKLIC
>NC_011989.1|WP_015916553.1|2471230_2472289_-|histidinol-phosphate-transaminase
MSRFWSPIVQSLTPYVAGEQPAISDLVKLNTNESPYGPSPHAIAAMRDAVDDTLRLYPDPTGLPLRHAIAKSHNLDPGEVFVGNGSDEVLAHTFQALLNHDKPLLFPDVSYSFYPTYCRLYGIDFREVALDDAMRVRIEDYRQPCGAIILPNPNAPTGIVLSLSEIETLVRDHPDQVVVIDEAYVDFGADSAIPLVKTYPNLLVVQTFSKSRGLAGLRVGFAVGQRALIEALERVKDSFNSYPLDRLALAGAVASWEDREWFERHRDLVVASRERLSLGLQGLGFEVLPSSANFVFARHSERSGADLTLALRQKSVLVRNFQKPRIGDFLRISIGTDAECDRLLGALREILD
>NC_011989.1|WP_041696822.1|2484305_2484530_-|hypothetical-protein
MTYDMTDLTMSEVLKDPMIRQLLRADGVSLSAFAVLLDDAARQRNLALRCRKAGVPAAHVIDSLSHVQAPADCL
>NC_011989.1|WP_015916565.1|2484912_2485734_-|thermonuclease-family-protein
MAARKAAGGARRGGANKRRSSGGTRAKRTGSGGSLWPWFGALVVVVAGVSAYDHRKELPGLIDKTFGTGGKYIAQLQGHAPRETSSRSETGPVPPASVPTPMARRLDPTPLPPATTMIPTASMMPRSRDDSPLPPATTLVPGQVVASLQPRGVDKQRVSGKFYYCGTSGLDNCVVDGDTFWVNKTKIRVADIDAPETEQAKCKSERDRGFAAKVRLRDLLSAGSFDLSPFGMRDEDQYGRKLRVVSRNGRSLGAMMVDEGLVRPWTGHRQPWC
>NC_011989.1|WP_139190210.1|2485919_2486348_-|copper-resistance-protein
MFKTGLYAALIATSLTASVAFAAETQIKVTETGEGGGAMGLKMEPATVAAGPAVFHVHNDAMSEDHEMIVVKLATPDAKIPLDTAKHRVDEKKLKSLGEVSDLKPGADGKLKVTLKPGSYLVFCNIKGHYEAGMQGTLTVTP
>NC_011989.1|WP_187152389.1|2486431_2487787_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MAAIRARISSRSLATGARLPSVRGFAKTMQVSVSTVVEAYERLAAEGLIRSRPGSGFFVAAPLAPLSLTNLGPRLEREIDPFWVSRQSLEAGGDLLKPGCGWLPPDWLPQAALRRAVRMLGRTDGAVLTDYGSPLGLPGLRQLLSRRMADHGLTVAADAIMLTESGTHAIDLVCRFFLEPGDCVLVDDPCYFNFHALLRAHRATIVGVPYLADGPDLAAFAAIVEAHKPRLYITNSGVHNPTGASLSAVNAHRLLTLADRADLTIVEDDIFADFEDVASARLSAFDGLNRVVQIGSFSKTLSASVRCGYIAARRDWIEGLTDLKIATSFGGGRLSAELVLAVLTDGGYRKHLEGLKTRLAGARSSVAAELSSLGFTPWLQPKAGLFLWCRMPDGIESGALARHCLDDGVILAPGNVFSLSQNAGRFMRFNVAQTMDARVLGSLKAGLHQLR
>NC_011989.1|WP_015916568.1|2487942_2488806_+|DMT-family-transporter
MNKTTSGLINGFLGMLIFSGSLPATRAAIGSFDPFFLTVARASIAGLLGCGLLLMFRPAKPNLAEIAALAMVSLCVVIGFPLLTAYALQHIPSARSLVFIALLPLSTALFAVLRGGERPRPIFWLFSSLGSALVIGFALSQGAATASYGDMLMILAILICGLGYAEGARLSRRLGGWQVICWALTLALPISVVAAAFTLPSTLSGVTAGAWLGLGYVSLFSMLIGFIFWYRGLAQGGIAAIGQLQLLQPFFGLALAAALLHETVSASMLVTTLAVVACVTGARRATL
>NC_011989.1|WP_015916569.1|2489103_2489742_+|porin-family-protein
MNKLTLLATAATLFVSTGIAMAADAVDQVPTAPAAVETPAAFSWAGGYIGVYGGYGWLDATLSQGGASLSDNFDGGRIGGFGGWNFDVGHNVILGVEADVNYDWNENNYSGVKVGMDVSGSARARAGYAIDRALIFVAGGWTADRTYIKSSSGDFNKTLNGWTIGAGVDYAITNRIFTRLEYRYNDYGTKNISGIDFDSKQNVVNLGIGIKF
>NC_011989.1|WP_015916570.1|2489801_2490548_-|SIMPL-domain-containing-protein
MVNLGAVLGLGRFGFMLASLAFVSPAMAQEASRQEAVINVSGEGEVSLAPDMALMQLGVVTEAAEAAQALKDNNEALAKVLKSLKDKGLADRDLQTSGFQITPRYRQEPEDKADSRPPVIEGYSVSNGLTIRVRDLSKLGGVIDTSVGLGANQGGEIRFTNDKPETAIDEARKAAMADALAKAKVLTQAAGVKLGRIISINENSARPFEQGMMMKASMARDMAPAPTPMAAGENTYRVTVNVSFALEQ
>NC_011989.1|WP_041696824.1|2491005_2491809_-|hypothetical-protein
MALLLFLREKHDGRQVLRDIGDLVAHRTERTRGLIHGEVWDNLVIARFHLEVLNGGDRVIDFGNLPDYFPDYLRATRRRLTRKEIEKNGLKVKVADRILSDVIKALKVLPNGRLSLGRLPTAQENPVLHSLTSVLAATTETTNELLVSQMASALRSQGLLKKGEEEVFRKASNFIGSFTVATMHRSEVLFADGGRVTLYADLDNERLNVLCELKAKEFNGVPAILMVVFRGPPKASVLAETPDEYLTLYHSDLEFDSAGQLTLVPIS
>NC_011989.1|WP_015916572.1|2492031_2492922_+|hypothetical-protein
MKPKITIKNVGFDGFGTGVHSNGPIEADFSNNTFNNVTTPYDLAPGSTGSIQNERIVNDPKLGFSGRNEASKRAEQTSSGWRMPAGPPMPSYCPKCQNIFPSKNYRFAGTFFTCWGNKEECPVCSFPNAELLEGTFDLSRETATILKAPDFSYEMLTRLKQLGADVAFGKLKVEEAIEIAESIYGPAGASLKKWVCFGIGFEIVRFFFEIVGGVDATWSMAQRLTDNNVVVDRVLESAFSSFSFNWQDYLEQPRGSIHSEPPTHELNSEEGRQPANEKAAEPQLPKVGPVPQPKPK
>NC_011989.1|WP_041696828.1|2493036_2493561_-|NAD(P)-dependent-oxidoreductase
MIAVYGALGKIGRLVVADLQGMGQSVVPINTDNELAAPASLHDIAIWCATSPPPHNRMEPFWEDFQSFMRLLHRPYRRVIFTSSFGIETGNGVEAINAYAAGKIAAEAFLKAWTEEDASRSGVAIRMGGYGPLTDVSMPWAMSEDQILAAYRAALLKPNGYHLIRPLHQDWMGE

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Crispr_ID: NC_011989_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011989_2

3603359-3603446

Orphan

Consensus_repeat	Method
GTCGCACTTCGCATACGTGAGAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_011989_2

>merge|NC_011989|2|3603359-3603446|CRISPRCasFinder
GTCGCACTTCGCATACGTGAGAAGAGCAAAGATGACTAAAATATACCCTTGTATTAGGTACGTTGTCGCACGTCGCATACGTGAGAAG

>NC_011989|2|2|3603359-3603446|CRISPRCasFinder
GTCGCACTTCGCATACGTGAGAAG	AGCAAAGATGACTAAAATATACCCTTGTATTAGGTACGTT
GTCGCACGTCGCATACGTGAGAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_011989.1\|WP_015917519.1\|3603779_3605084_-\|capsular-biosynthesis-protein	unknown	unknown	gnl\|CDD\|319749
NC_011989.1\|WP_015917524.1\|3611724_3612753_-\|zinc-metalloprotease-HtpX	unknown	unknown	gnl\|CDD\|234944
NC_011989.1\|WP_015917511.1\|3596682_3597966_-\|glutamate-5-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|234685
NC_011989.1\|WP_015917515.1\|3601218_3601806_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NC_011989.1\|WP_139192356.1\|3613894_3615274_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|227278
NC_011989.1\|WP_041697248.1\|3608460_3610137_-\|heparinase-II/III-family-protein	unknown	unknown	gnl\|CDD\|227658
NC_011989.1\|WP_015917528.1\|3615263_3616598_+\|S41-family-peptidase	unknown	unknown	gnl\|CDD\|223864
NC_011989.1\|WP_015917510.1\|3596051_3596708_-\|nicotinate-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|234611
NC_011989.1\|WP_015917513.1\|3599133_3600234_-\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237048
NC_011989.1\|WP_041697246.1\|3606691_3608308_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NC_011989.1\|WP_015917514.1\|3600321_3601182_+\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|226098
NC_011989.1\|WP_041697243.1\|3595551_3596016_-\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|223870
NC_011989.1\|WP_015917516.1\|3601805_3602438_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NC_011989.1\|WP_015917512.1\|3597958_3599137_-\|glutamate-5-kinase	unknown	unknown	gnl\|CDD\|235460
NC_011989.1\|WP_015917525.1\|3612862_3613093_+\|DUF1674-domain-containing-protein	unknown	unknown	gnl\|CDD\|227795
NC_011989.1\|WP_015917520.1\|3605219_3606572_+\|capsular-biosynthesis-protein	unknown	unknown	gnl\|CDD\|319749
NC_011989.1\|WP_015917517.1\|3602565_3602838_-\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NC_011989.1\|WP_015917518.1\|3602876_3603191_-\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NC_011989.1\|WP_015917526.1\|3613287_3613515_+\|hypothetical-protein	unknown	unknown	unknown
NC_011989.1\|WP_015917523.1\|3610252_3611734_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|223222

Protein	Function_ID	Function_description	E-value
NC_011989.1\|WP_015917519.1\|3603779_3605084_-\|capsular-biosynthesis-protein	gnl\|CDD\|319749	cd16441, beta_Kdo_transferase_KpsS, beta-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo)-transferase KpsS. KpsS is a beta-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo)-transferase. It is part of the ATP-binding cassette transporter dependent capsular polysaccharides (CPSs) synthesis pathway, one of two CPS synthesis pathways present in Escherichia coli. The poly-Kdo linker is thought to be the common feature of CPSs synthesized via this pathway. CPSs are high-molecular-mass cell-surface polysaccharides that are important virulence factors for many pathogenic bacteria.	3.2797e-132
NC_011989.1\|WP_015917524.1\|3611724_3612753_-\|zinc-metalloprotease-HtpX	gnl\|CDD\|234944	PRK01345, PRK01345, heat shock protein HtpX; Provisional.	0
NC_011989.1\|WP_015917511.1\|3596682_3597966_-\|glutamate-5-semialdehyde-dehydrogenase	gnl\|CDD\|234685	PRK00197, proA, gamma-glutamyl phosphate reductase; Provisional.	0
NC_011989.1\|WP_015917515.1\|3601218_3601806_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.38918e-33
NC_011989.1\|WP_139192356.1\|3613894_3615274_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|227278	COG4942, COG4942, Membrane-bound metallopeptidase [Cell division and chromosome partitioning].	3.19295e-99
NC_011989.1\|WP_041697248.1\|3608460_3610137_-\|heparinase-II/III-family-protein	gnl\|CDD\|227658	COG5360, COG5360, Uncharacterized protein conserved in bacteria [Function unknown].	0
NC_011989.1\|WP_015917528.1\|3615263_3616598_+\|S41-family-peptidase	gnl\|CDD\|223864	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane].	6.0784e-148
NC_011989.1\|WP_015917510.1\|3596051_3596708_-\|nicotinate-nucleotide-adenylyltransferase	gnl\|CDD\|234611	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase.	5.02438e-77
NC_011989.1\|WP_015917513.1\|3599133_3600234_-\|GTPase-ObgE	gnl\|CDD\|237048	PRK12299, obgE, GTPase CgtA; Reviewed.	0
NC_011989.1\|WP_041697246.1\|3606691_3608308_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NC_011989.1\|WP_015917514.1\|3600321_3601182_+\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|226098	COG3568, ElsH, Metal-dependent hydrolase [General function prediction only].	1.29884e-42
NC_011989.1\|WP_041697243.1\|3595551_3596016_-\|ribosome-silencing-factor	gnl\|CDD\|223870	COG0799, COG0799, Uncharacterized homolog of plant Iojap protein [Function unknown].	6.11062e-49
NC_011989.1\|WP_015917516.1\|3601805_3602438_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	1.13407e-30
NC_011989.1\|WP_015917512.1\|3597958_3599137_-\|glutamate-5-kinase	gnl\|CDD\|235460	PRK05429, PRK05429, gamma-glutamyl kinase; Provisional.	0
NC_011989.1\|WP_015917525.1\|3612862_3613093_+\|DUF1674-domain-containing-protein	gnl\|CDD\|227795	COG5508, COG5508, Uncharacterized conserved small protein [Function unknown].	6.26852e-15
NC_011989.1\|WP_015917520.1\|3605219_3606572_+\|capsular-biosynthesis-protein	gnl\|CDD\|319749	cd16441, beta_Kdo_transferase_KpsS, beta-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo)-transferase KpsS. KpsS is a beta-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo)-transferase. It is part of the ATP-binding cassette transporter dependent capsular polysaccharides (CPSs) synthesis pathway, one of two CPS synthesis pathways present in Escherichia coli. The poly-Kdo linker is thought to be the common feature of CPSs synthesized via this pathway. CPSs are high-molecular-mass cell-surface polysaccharides that are important virulence factors for many pathogenic bacteria.	1.98691e-143
NC_011989.1\|WP_015917517.1\|3602565_3602838_-\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	2.23703e-54
NC_011989.1\|WP_015917518.1\|3602876_3603191_-\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	2.36278e-52
NC_011989.1\|WP_015917523.1\|3610252_3611734_-\|MFS-transporter	gnl\|CDD\|223222	COG0144, Sun, tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis].	2.20011e-100

>NC_011989.1|WP_015917518.1|3602876_3603191_-|50S-ribosomal-protein-L21
MFAVIKTGGKQYRVAANDVLTIEKLEAEAGAIVEFTEILVVGVGADATIGAPFVAGATVKAEVVEHNRGKKVIAFKKRRRQNSKRSRGHRQHHTVVRITDIVAA
>NC_011989.1|WP_015917517.1|3602565_3602838_-|50S-ribosomal-protein-L27
MAHKKAGGSSRNGRDSESKRLGVKKFGGEVVIPGNIIVRQRGTQWHPGANVGMGKDHTIFALTTGNVTYRTKSNGRVFVSVMPKTAEAAE
>NC_011989.1|WP_015917516.1|3601805_3602438_-|GNAT-family-N-acetyltransferase
MERLLLRDDQLRSPDDRLRPDRLRQSCPVLLSQRLVMRAPHVEDIDALTHLANNAAVATMVSRMPHPYTAADAADFVRRSNLGEIGKCVYAITKGENGEFLGCCALEPHTDLETLEIGYWLGEPYWNNGYATEAAHALIDMAFRTRDIAFIDARCRVTNVAARRVIQKCGFQFQGSGMVGHLAARGMVPVEWYRLDRKTWMSLKSWGEMR
>NC_011989.1|WP_015917515.1|3601218_3601806_-|GNAT-family-N-acetyltransferase
MAALEKPRLQTRFPSLGPCPVIETPRLVLRPHRLSDADAIAASLNDWQVTRMLSRVPMPYDRQDACDWLNRISAGVMPDWHLAITSGDDVHIGMVGLELRHGLWHLGYWLNRFYWGQGLMSEAAQAAVERFFRRMPEAVLHSGAFADNAASLKIQEKLGFTLTRCADLYSLSRNAMAPHVETRLTQDGFQRAKAF
>NC_011989.1|WP_015917514.1|3600321_3601182_+|endonuclease/exonuclease/phosphatase-family-protein
MRFVSYNIQYGIGLDGKFDPIRIAKNLEGADVIALQEVTRGYPANGGADLPEIFANHFPEYHWVYGPACDLHASSALIKGRRVDKRFQFGNMVLSRWPILANRMLLLPRTRTFEKLNNQRAATEAVIDAPGGALRVYSVHLDHVAPDERIAQIRFLKDRAINFIQEGGAMTGGQEFALPQPPLPEDFLLMGDFNMQPESPEYREMVGTIDAYYGRTARADAPLDALARLGKLNAGSYSWEEVGKPDMRMHLDYCFLSGSLAHRLKAASVDTDAVGSDHFPVWVELD
>NC_011989.1|WP_015917513.1|3599133_3600234_-|GTPase-ObgE
MKFLDEAKVYIRSGDGGAGAVSFRREKFIEFGGPDGGDGGRGGDVWVEAVNGLNTLIDFRFQQHFKATVGTHGMGRNRTGANGEHVTLKVPVGTQIFEEDAETLIVDMVTEGQRFRLAAGGNGGFGNAHFKSATNQAPDWANPGLEGEEKTIWLRLKLIADAGLVGLPNAGKSTFLAAVTRARPKIANYPFTTLHPNLGVATVDEREFILADIPGLIEGAHEGVGIGDRFLGHVERTRVLLHLVSAQEEDVAKAYTTVAHELEAYDGGLEDKPEIVALSQIDVLDEDELKKKLKALQKACSKKPMMISAITGKGMLEVLRALRDVIVENRSYDDETISQRPKKHRHKLEDRPQHENGPEESEEGEE
>NC_011989.1|WP_015917512.1|3597958_3599137_-|glutamate-5-kinase
MSAPLASLSHYKRIVIKIGSALLVDRGAGLKHAWLDAVCDDIAALRAKGVEVLVVSSGAIALGRTVLNLPGGALKLEESQAAAAVGQIALARHWSESLSRSSIVAGQILLTLGDTEERRRYLNARATISQLLKLGAVPIINENDTVATTEIRYGDNDRLAARVATMTGADLLILLSDIDGLYTAPPHLDPEAKLLPVIAEITPEIEAMAGGAASELSRGGMRTKIDAGKIATSAGCAMIITSGKLLNPLRGIDEGAAHSWFAPSAMPVTARKTWIAGQLQPAGILSVDAGAETALRAGKSLLPAGVREVSGHFHRGDTISVVGLEGREIARGLAGYDADEARRIAGHKSAEIEALLGYAGRSAMIHRDDLVMTEQTGRKAGKSTKKKDEAHA
>NC_011989.1|WP_015917511.1|3596682_3597966_-|glutamate-5-semialdehyde-dehydrogenase
MLDTVAKADGIDALMLDIGAKAKAAARPLAIASADQKNAALMAMSEAILSGKSQIIAANAIDLKAAETAGLAASFIDRLTLNEERITAMAKGLREVAELKDPVSEVIAAWERPNGLKIERVRTPLGVIGVIYESRPNVTADAGALCLKSGNAVILRGGSDSVNSSRAIHACLVAGLVAAGLPDHAIQLVPVTDRAAVGAMLTGLNGTIDVIVPRGGKSLVARVQSDARVPVFAHLEGLCHVYVDGSADLDMAKSIVVNAKMRRTGICGSAETLLVDSAAIGSHLMPLLEALTEAGCEIRASATVLKVFPGLKAAVDEDWRTEYLDAIISVAVVDGIGGAIDHIARYSSNHTEAVIAEDPAVVERFFNEVDSAILLHNASTQFADGGEFGMGGEIGIATGKMHARGPVGVEQLTSFKYRVHGTGQIRP
>NC_011989.1|WP_015917510.1|3596051_3596708_-|nicotinate-nucleotide-adenylyltransferase
MAPGRSGPDVSHSGVAAHYLRMPHTERGMVVGLFGGSFNPPHQGHVLVAEIALRRLGLDQLWWMVTPGNPLKNHSQLAPLAERLALCEGLAQDPRLKITAFEAELGTSYTARTLDHVKRLNPHVHFIWIMGADNLRSFHHWQDWQKIAMTFPIAVIDRPGATLSYLSSKMAQRFDFARVDESDAGVLWRRQAPAWTFIHGPRSMLSSTALRTGPVLKD
>NC_011989.1|WP_041697243.1|3595551_3596016_-|ribosome-silencing-factor
MGASESFSCCYRRKGQTLTTVHTKGRATVAIPQSPERGVDAAARALELVLTSLEDSKAEDIVSIDIAGKSALGDYMVVVSGRSSRHVVAICEHLVSDLKDEGFGAPRVEGLETGDWVLIDAGDIIIHVFRPEIREFYNIEKMWAAPDIEESRLH
>NC_011989.1|WP_015917519.1|3603779_3605084_-|capsular-biosynthesis-protein
MTKRRTFLFLQGPASPFLPALARALETRDVAVGKVNFCSGDVIFWRKWPFDFFRGRDDAWPGFLERLILRHGITDVLMLGDGRPKHAAAVALCTRLGLRAHIFEHGYLRPDWLTLEPFGMSSQSRFPVDPQAIAALAQGVEAPQPRSPYPSSFLTYALYDLIYHIPNVALGWLLHPHYKAHGPVHPVVEYSGWIIKGLTARRRKAQAVRLQQRYLATDREFDFYLFPLQLPGDYQIRRHAPMGDLFRILQAVIRSFADRAPSGSRLLFKTHPIDNGLRDWSSDIARMAERCGIANQVDVIDGGDLTALIGASRGLVTVNSTVGLTALQQAIPVMALAPAIYDVPGLTHQQSLASFWQAPELPDATLLNRLIRAMTATIQLPGGFIGKQAITDGATAMADRLLAETKPLAHEPSPERSRFRYESELLELEAVGLR
>NC_011989.1|WP_015917520.1|3605219_3606572_+|capsular-biosynthesis-protein
MTSVEPTKAVLFLQGPPSILWTEFARAFEQAGVKTHHVNFTLGDFLFWRKRGAKNYRGSFSKWPAYLRRLIAEKGITDIVYYADRLPYHAKAAEIGEELGVRCHAVEWGYLRPDWLTFERDGMGRFSHFPNDPKAIRAIAAKVEEPDIAVKYPHTFGQEAFNEVIYNLLNFFGRPFYPLYNADKYYSALVDYLPWLLKAGVKPARLPEGFLEDGQPPFYLVALQLQSDYQIRANSPYRHLRDMMRQVIASFVKNAPAGSKLLFKQHPLDNGLERWHKVLRHIAREFKIEDRVVFIEEGDLHDILQKTAGVVIVNSTVGLHSLRAQKPTIVLGCAVFDVPGLTHQGRLDDFWKRPEPVDPELMRDLVKAMAATIQIKGDFFNKAGRQAAIGAMVQRVIEGTVNMPDAFIDPPPRLTSPKGILTVLGRPVELDWEEDAAVPDMTYARSGPIR
>NC_011989.1|WP_041697246.1|3606691_3608308_-|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MAVVSKKIPVPDRVQVRTALLSVFDKSGIVDLARALNDMGVRLLSTGGTYKALIEAGLPATDVSDVTGFPEIMDGRVKTLHPAVHGGLLAIRDDEDHVKAMQAHKIEAIDLAVINLYPFEAVLAAGGDYPTTVENIDIGGPAMIRASAKNHAYVTVVTDPADYAQLLDALKADDCHTPYALRQQFAARAYARTAAYDATISNWFAEALAIETPRNRVIGGSLREEMRYGENPHQKAGFYVNGDQRPGVATATLLQGKQLSYNNINDTDAAFELVSEFLPENGPACAIIKHANPCGVAVGKTLADAYRRALACDSVSAFGGIIALNQTLDAETAEEIVKLFTEVIIAPDVTEEAKAIIARKANLRLLTTGGLADPRAPGLTAKTVSGGLLVQSRDNLVVEDLDLKVVTKRAPTAAELEDMKLAFKIAKHVKSNAVIYAKDGQAVGIGAGQMSRVDSARIAAMKAEDAAKAMGLAEPLTRGSAVASEAFYPFADGLLAAIAAGATAVIQPGGSMRDAEVIAAADEHGVAMVFTGVRHFRH
>NC_011989.1|WP_041697248.1|3608460_3610137_-|heparinase-II/III-family-protein
MPQRQGQSLPVLYVREGWRRWKRRGWLPVRAAFSRLRRRQVRLLVAPTDLRVVDSHVATEIFEGRFPLAGRLLECGRASPFTLELPSQVFAAKLHSFSWLRHIRANKTPEASAHARAIVDSWIKLNGKRVGIGWEAGILGQRIIAWLSHSPVVLQDCESGFYRRFLKSLSRQVAYAGLIADLAPDGVDRLRLRIALAMASIAMSASARQIRKAAHFLDLELERQVLADGGHISRNPQAALDILFDLLPLRQTYVNLGHDVPIKLISTIDRMFPAIRFFRHSNGDLALFNGATATLANDLMSVLRYDESGGQPFRALPHSHYQRLAAGGAVVLVDTGVPAQGDISRSAHAGCLSFELSCGRHRLVVNSGTPRFAGERYRQMARATAAHSTLVIGDQSSCRISTSRFLGPIIVGGVSSVEVMRRAGDDGSDHLTARHDGYLKGFGILHERDLRLNAAGTKLVGHDRLLSDKEQPLADMPKGGTIIRFHIHPSVRLTQEDDHNIRLVANGGSETWVFSSPTGFPVIAEDVFFAGLSGIQASEQIELVLETPEIWWFFSKQG
>NC_011989.1|WP_015917523.1|3610252_3611734_-|MFS-transporter
MELNERRGKSPTDKSSSGHRESSLGTPGKQDGQSRQKSDRPRRQVHDDKPGLEARMAASRLLAAVIDRKTSLDGMMDGDHGNPAYAALSEADRGLVRAILNTSLRFLPRIEAMLARLLDAPLPDGARALYHSLIVAAAQMVYLDVPDHSAVDLAVEQANRDPRSRRFAKLVNAVLRRLGREKQALLADVEDVICMPDWFFERLIAVYGEEEARRIAQAQLTPAAIDLTVKADPAVWAEKLNGVVLPTGSIRLASFAGAVSALPGFEEGAWWVQDAAAALPVRMFGSLEGKRAVDLCAAPGGKTAQLAAAGAVVTAVEQSANRLKRLNGNLQRLGFSAQLVHQDLMEFNLGEDHPGFDAVLLDAPCSSTGTTRRHPDVFYTKGPQDIVKLAGVQERLLRHAVTLLAPGGSIVFSNCSLDPQEGEDVVARVLADHPELERVAMQVADWPGLEDAITPLGEFRTTPAMLPGPAMLPGGDSHAGGLDGFYACRLRRV
>NC_011989.1|WP_015917524.1|3611724_3612753_-|zinc-metalloprotease-HtpX
MNIMRTAMLLAFMTALFMGVGFLIGGKGGMMIALVIAGAMNLFSYWNSDRMVLSAYHAQEVDPRNAPEFYEIVRGLTQNAGLPMPKVYIFDNPQPNAFATGRNPQNAAVAASTGLLQALTPEEVAGVMAHELAHVEHRDTLTMTITATLAGAISMLGNFAFFFGGRRDENGNGGGIIGPLVAMIVAPFAAMLVQMAISRTREYAADRRGAEICGNPLWLASALAKIAGAHQPNYQAERNPATAHMFIINPLSGQKMDSLFSTHPDTSNRIAALQALAQEMGGRQANVYRPQHSKPAASGPWGSSAERSTDDPWGVKGGASTRSVPKIGRRGKDNDAPKGPWN
>NC_011989.1|WP_015917525.1|3612862_3613093_+|DUF1674-domain-containing-protein
MDEHQNDRQDSGTANSDGTDAAPKTLSPAAVRALAEAEERRKAEQAQKPAPEVGGRGGADPARFGDWEINGRAIDF
>NC_011989.1|WP_015917526.1|3613287_3613515_+|hypothetical-protein
MKKIVLATAFALTTIIANIVPAQAQSPRMPPPDDDRRGPPHHMQRPPPPPPHCKVRKVVRWHHGEKIVKRVRVCR
>NC_011989.1|WP_139192356.1|3613894_3615274_+|peptidoglycan-DD-metalloendopeptidase-family-protein
MAQQLPAPDNAVSTQPSINPTSPNDIGPQAGPETSSQTSPDDPAGALRAKREDVSRQLQDLSQSMQLSSEKSEELRKSIDALDKSSTSLRQALIDSAARRKDLEQKIADGEKKLADYGVRQDVIHKSFRARRAVLAEVLGALERMGRNPPPALLVTPEDALGAVRTAILLGAVVPGMRKETEKLASDLQELTNLRKASIDEREKMVASLKSRQEEEARMDMLLAENARLSQQNNAQLQEELARSQELAQKSSSLQGLIGSLENEIASVRQATDQAKLEEEKRRQMTDAQRDQARLEAQTTPPDKNRIAPAFSFEELKAKLELPAVGDVLRQFGDPDGTGHEAKGIVLATAPAAVVIAPADGTVVYAGQFRSYGKMAILNTGNGYHIVLSGMDRVNVHAGQFVLSGEPIGAMGEKRVVSAAAFALETDRPTLYIEFRKDGNSVDSRPWWAKDAGKVRNDT
>NC_011989.1|WP_015917528.1|3615263_3616598_+|S41-family-peptidase
MIRRASIMLVGALMGATAMSVVYSAGVPAQAAGNSTYKELAIFGDVFERVRAQYVTPPDEKKLVEAAINGMLSSLDPHSSYMNAQEAADMQTQTKGEFGGIGIEVTMENDLVKVITPIDDTPGAKAGILAGDMISEINGTPVRGMQLNDAVEKMRGAVNTPIKLTILRKGADKPIEMSVMREIIPIRAVKSRVDGDVGYVRVISFTEKTYDDLEAAINKIKKEVPADKLKGFVLDLRLNPGGLLDQAIYVSDAFLQKGEIVSTRSRDPEDTRRFNATAGDLTDGKPLIVLVNGGSASASEIVAGALQDLKRATVVGTRSFGKGSVQTIIPMGDKGALRLTTALYYTPSGKSIQGTGIHPDIKVEEPLPADLQGKLRTEGESSLPGHIQGQSETEEGSGSVAYVPPDPKDDVQLNYALDLLRGAKTDPSFPPDPSKAVLESAKKK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

560423 : 595966

Stx2-converting_phage(50.0%)

transposase,integrase

attL 566499:566513|attR 570389:570403

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015914890.1\|560423_561521_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_015917605.1\|561679_562024_-	HNH endonuclease	NA	NA	NA	NA
WP_015914891.1\|562781_563984_+	SIR2 family protein	NA	NA	NA	NA
WP_015914892.1\|563970_566100_+	DUF87 domain-containing protein	NA	NA	NA	NA
WP_041696167.1\|566101_567139_+	hypothetical protein	NA	NA	NA	NA
566499:566513	attL	NA	NA	NA	NA
WP_015914893.1\|567359_567950_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_015914894.1\|568070_568496_+	tautomerase family protein	NA	NA	NA	NA
WP_015914895.1\|568574_568970_+	VOC family protein	NA	NA	NA	NA
WP_015914896.1\|569267_569900_+\|integrase	tyrosine-type recombinase/integrase	A0A0A8WF93	Clostridium_phage	6.6e-08	27.9
WP_015914897.1\|570316_570907_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
570389:570403	attR	NA	NA	NA	NA
WP_015914898.1\|570926_571211_+	hypothetical protein	NA	NA	NA	NA
WP_187152370.1\|572038_572386_-	hypothetical protein	NA	NA	NA	NA
WP_041696171.1\|572390_573230_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_015914901.1\|573251_573578_-	hypothetical protein	NA	NA	NA	NA
WP_015914902.1\|573583_574129_-	hypothetical protein	NA	NA	NA	NA
WP_015914903.1\|574297_575197_+	LysR family transcriptional regulator	Q6JIH3	Burkholderia_virus	1.7e-20	27.6
WP_041696175.1\|576186_576819_-	hypothetical protein	NA	NA	NA	NA
WP_015914905.1\|576892_577795_+	hypothetical protein	NA	NA	NA	NA
WP_015914906.1\|577837_578497_+	hypothetical protein	NA	NA	NA	NA
WP_015914907.1\|578894_580172_+	ATP-binding protein	NA	NA	NA	NA
WP_015914908.1\|580496_581183_-	hypothetical protein	NA	NA	NA	NA
WP_041696179.1\|581317_581566_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_015914909.1\|581651_581999_-	hypothetical protein	NA	NA	NA	NA
WP_015914910.1\|581995_583660_-	type IV secretory system conjugative DNA transfer family protein	NA	NA	NA	NA
WP_041696181.1\|583656_583989_-	hypothetical protein	NA	NA	NA	NA
WP_015914911.1\|584242_587560_+	Ti-type conjugative transfer relaxase TraA	NA	NA	NA	NA
WP_015914912.1\|587843_589361_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_015914913.1\|589350_590145_+	ATP-binding protein	A0A059NT77	Lactococcus_phage	5.9e-30	34.5
WP_015914914.1\|590873_591326_+	IS66 family insertion sequence hypothetical protein	NA	NA	NA	NA
WP_012650519.1\|591322_591676_+	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZDM8	Stx2-converting_phage	7.4e-33	57.8
WP_015914915.1\|591721_593380_+\|transposase	IS66 family transposase	A0A0P0ZEB3	Stx2-converting_phage	1.5e-96	39.9
WP_012650518.1\|593360_593594_-	hypothetical protein	NA	NA	NA	NA
WP_041696188.1\|593624_593933_+\|transposase	transposase	NA	NA	NA	NA
WP_015914916.1\|593929_594283_+	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_015914917.1\|594352_595966_+\|transposase	IS66 family transposase	A0A0P0ZEB3	Stx2-converting_phage	1.4e-91	41.0

DBSCAN-SWA_2

733304 : 740403

Pseudomonas_phage(50.0%)

portal,tail,terminase,protease,head,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015915030.1\|733304_734531_+\|portal	phage portal protein	M1PLL1	Streptococcus_phage	2.3e-41	33.2
WP_041696241.1\|734520_734925_+	hypothetical protein	NA	NA	NA	NA
WP_015915031.1\|734924_735476_+\|head,protease	HK97 family phage prohead protease	A0A2D1GNL2	Pseudomonas_phage	1.3e-23	43.1
WP_139192424.1\|735615_736689_+\|capsid	phage major capsid protein	B0VK33	Azospirillum_phage	2.2e-59	42.4
WP_015915033.1\|736723_737110_+	hypothetical protein	NA	NA	NA	NA
WP_015915034.1\|737112_737475_+	hypothetical protein	NA	NA	NA	NA
WP_015915035.1\|737471_737960_+	hypothetical protein	A0A2D1GNF2	Pseudomonas_phage	1.5e-15	34.4
WP_015915036.1\|737963_738434_+	hypothetical protein	NA	NA	NA	NA
WP_015915037.1\|738430_738742_+\|head,tail	phage head-tail connector protein	NA	NA	NA	NA
WP_041697540.1\|739247_739661_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_015915039.1\|739657_739969_+\|head	phage head closure protein	NA	NA	NA	NA
WP_015915040.1\|739965_740403_+\|terminase	phage terminase small subunit P27 family	NA	NA	NA	NA

DBSCAN-SWA_3

1120419 : 1127582

Geobacillus_phage(33.33%)

portal,tail,protease,head,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015915375.1\|1120419_1121622_+\|portal	phage portal protein	W8ECU7	Geobacillus_phage	6.6e-57	37.3
WP_015915376.1\|1121811_1122129_+	hypothetical protein	NA	NA	NA	NA
WP_015915377.1\|1122177_1122747_+\|head,protease	HK97 family phage prohead protease	A0A2H4JAI0	uncultured_Caudovirales_phage	8.0e-29	46.7
WP_015915378.1\|1122758_1124021_+\|capsid	phage major capsid protein	Q3HQT0	Burkholderia_phage	4.0e-81	44.1
WP_015915379.1\|1124125_1124695_+\|head,tail	phage head-tail connector protein	NA	NA	NA	NA
WP_015915380.1\|1124709_1125033_+\|head	phage head closure protein	NA	NA	NA	NA
WP_156597767.1\|1125029_1125206_+	hypothetical protein	NA	NA	NA	NA
WP_015915381.1\|1125186_1125585_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_015915382.1\|1125574_1126819_-	MFS transporter	NA	NA	NA	NA
WP_015915383.1\|1127171_1127582_+\|tail	phage major tail protein, TP901-1 family	NA	NA	NA	NA

DBSCAN-SWA_4

1600132 : 1633484

Rhizobium_phage(27.78%)

portal,integrase,terminase,tail,protease,head,tRNA,capsid

attL 1599728:1599746|attR 1619403:1619421

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1599728:1599746	attL	NA	NA	NA	NA
WP_015915807.1\|1600132_1601020_+\|tRNA	tRNA 2-thiocytidine(32) synthetase TtcA	A0A0U2S5Z2	Escherichia_phage	5.0e-70	49.2
WP_041696490.1\|1601072_1601900_+	inositol monophosphatase	NA	NA	NA	NA
WP_015915809.1\|1601927_1602749_+	inositol monophosphatase family protein	NA	NA	NA	NA
WP_015915810.1\|1602822_1604028_-	multidrug effflux MFS transporter	NA	NA	NA	NA
WP_015915811.1\|1604285_1604621_-	Grx4 family monothiol glutaredoxin	NA	NA	NA	NA
WP_041696492.1\|1604722_1604923_-	hypothetical protein	NA	NA	NA	NA
WP_015915812.1\|1604938_1605175_-	BolA family transcriptional regulator	NA	NA	NA	NA
WP_015915813.1\|1605213_1607451_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.3e-162	41.8
WP_085946625.1\|1607816_1608410_+	DnaJ domain-containing protein	Q8QNB4	Ectocarpus_siliculosus_virus	9.6e-09	47.5
WP_139192370.1\|1608509_1608713_+	hypothetical protein	NA	NA	NA	NA
WP_139192369.1\|1608812_1609625_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_015915816.1\|1609646_1610378_-	lipoyl(octanoyl) transferase LipB	NA	NA	NA	NA
WP_187152382.1\|1611038_1612052_+	ABC transporter permease	NA	NA	NA	NA
WP_049777160.1\|1612076_1613144_-\|integrase	tyrosine-type recombinase/integrase	G8DH71	Emiliania_huxleyi_virus	4.3e-68	40.3
WP_015915819.1\|1614154_1615162_-	hypothetical protein	NA	NA	NA	NA
WP_015915820.1\|1615575_1616190_-	helix-turn-helix transcriptional regulator	A0A1W6JND9	Staphylococcus_phage	1.4e-07	27.3
WP_041696500.1\|1616277_1616529_+	hypothetical protein	NA	NA	NA	NA
WP_015915821.1\|1616744_1617242_+	hypothetical protein	R9TQJ7	Rhizobium_phage	2.5e-42	59.0
WP_041696502.1\|1617238_1617475_+	hypothetical protein	NA	NA	NA	NA
WP_015915822.1\|1617560_1618121_+	hypothetical protein	NA	NA	NA	NA
WP_015915823.1\|1618117_1618411_+	hypothetical protein	NA	NA	NA	NA
WP_041697883.1\|1618410_1619691_+	helix-turn-helix domain-containing protein	A0A291AUK7	Sinorhizobium_phage	4.6e-24	32.5
1619403:1619421	attR	NA	NA	NA	NA
WP_015915825.1\|1619677_1620334_+	transcriptional antiterminator	NA	NA	NA	NA
WP_139192368.1\|1620558_1620768_-	hypothetical protein	NA	NA	NA	NA
WP_015915826.1\|1621002_1621470_+\|terminase	P27 family phage terminase small subunit	NA	NA	NA	NA
WP_139192375.1\|1621456_1623268_+\|terminase	terminase large subunit	A0A0U2C138	Paracoccus_phage	2.1e-147	49.4
WP_015915828.1\|1623280_1624588_+\|portal	phage portal protein	B4UTP1	Rhizobium_phage	2.7e-128	61.7
WP_015915829.1\|1624562_1625159_+\|head,protease	HK97 family phage prohead protease	B4UTP2	Rhizobium_phage	2.4e-36	49.4
WP_041696504.1\|1625200_1626472_+\|capsid	phage major capsid protein	B4UTP3	Rhizobium_phage	4.9e-119	55.3
WP_041696506.1\|1626532_1626814_+	hypothetical protein	NA	NA	NA	NA
WP_015915831.1\|1626810_1627359_+	hypothetical protein	NA	NA	NA	NA
WP_041696508.1\|1627358_1627556_+	hypothetical protein	NA	NA	NA	NA
WP_041696509.1\|1627530_1627893_+\|head,tail	head-tail adaptor protein	A0A141GEW5	Brucella_phage	5.5e-23	46.3
WP_015915832.1\|1627889_1628351_+	HK97 gp10 family phage protein	B4UTQ0	Rhizobium_phage	3.6e-11	33.9
WP_015915833.1\|1628347_1628755_+	DUF3168 domain-containing protein	A0A141GEW7	Brucella_phage	1.7e-17	40.0
WP_015915834.1\|1628781_1629225_+	hypothetical protein	A0A2D2W2I6	Sinorhizobium_phage	2.8e-13	31.5
WP_041697891.1\|1629221_1629605_+	gene transfer agent family protein	NA	NA	NA	NA
WP_015915835.1\|1629964_1630828_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	2.3e-96	58.2
WP_015915836.1\|1630905_1631811_-	dTDP-4-dehydrorhamnose reductase	NA	NA	NA	NA
WP_015915837.1\|1631807_1632866_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	4.4e-97	51.0
WP_015915838.1\|1632920_1633484_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	7.2e-38	44.5

DBSCAN-SWA_5

1879237 : 1922668

Rhizobium_phage(45.45%)

portal,plate,integrase,tail,terminase,head,capsid

attL 1875820:1875835|attR 1930559:1930574

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1875820:1875835	attL	NA	NA	NA	NA
WP_015916059.1\|1879237_1880278_-\|integrase	tyrosine-type recombinase/integrase	F8TUV0	EBPR_podovirus	4.8e-72	43.7
WP_139192391.1\|1880497_1880767_-	hypothetical protein	NA	NA	NA	NA
WP_041696596.1\|1880892_1881738_-	hypothetical protein	NA	NA	NA	NA
WP_015916061.1\|1882220_1885514_-	error-prone DNA polymerase	Q8W6C3	Saccharomonospora_phage	5.6e-82	25.2
WP_041696599.1\|1885510_1887022_-	DNA polymerase Y family protein	NA	NA	NA	NA
WP_015916063.1\|1886942_1887695_-	hypothetical protein	NA	NA	NA	NA
WP_071204222.1\|1888269_1888746_-	hypothetical protein	NA	NA	NA	NA
WP_015916065.1\|1889610_1890024_-	type II toxin-antitoxin system HicB family antitoxin	NA	NA	NA	NA
WP_015916066.1\|1890440_1891022_-	hypothetical protein	NA	NA	NA	NA
WP_015916067.1\|1891840_1892251_+	Prophage antirepressor	R9TP95	Rhizobium_phage	1.1e-14	33.9
WP_139192390.1\|1893533_1894172_+	hypothetical protein	R9TRT9	Rhizobium_phage	6.4e-43	46.3
WP_080516976.1\|1894398_1894590_-	DUF1508 domain-containing protein	NA	NA	NA	NA
WP_015916069.1\|1894754_1895384_+\|tail	phage tail protein	A0A0A8IL87	Aurantimonas_phage	5.9e-41	47.3
WP_015916070.1\|1895628_1896231_+	hypothetical protein	R9TNC8	Rhizobium_phage	2.9e-61	62.7
WP_015916071.1\|1896227_1898243_+\|terminase	phage terminase large subunit family protein	A0A068CDC0	Rhizobium_phage	0.0e+00	77.0
WP_015916072.1\|1898239_1899877_+\|portal	phage portal protein	R9TN54	Rhizobium_phage	2.4e-235	75.3
WP_041696611.1\|1899876_1900143_+	hypothetical protein	NA	NA	NA	NA
WP_015916073.1\|1900152_1901073_+	S49 family peptidase	A0A068CE01	Rhizobium_phage	4.5e-114	66.1
WP_139192389.1\|1901218_1901671_+	hypothetical protein	A0A068C988	Rhizobium_phage	4.6e-11	40.0
WP_015916075.1\|1901674_1902037_+\|head	head decoration protein	NA	NA	NA	NA
WP_015916076.1\|1902048_1903065_+\|capsid	major capsid protein	A0A0A8ILA9	Aurantimonas_phage	4.1e-68	41.5
WP_015916077.1\|1903142_1903622_+	hypothetical protein	NA	NA	NA	NA
WP_015916078.1\|1903625_1903997_+	hypothetical protein	NA	NA	NA	NA
WP_041696613.1\|1903999_1904785_+	hypothetical protein	NA	NA	NA	NA
WP_015916079.1\|1904781_1905324_+\|plate	phage baseplate assembly protein V	A0A1B2LRU5	Wolbachia_phage	3.7e-07	28.7
WP_015916080.1\|1905320_1905716_+	GPW/gp25 family protein	NA	NA	NA	NA
WP_015916081.1\|1905719_1906577_+\|plate	baseplate J/gp47 family protein	K4HZB7	Acidithiobacillus_phage	5.1e-35	37.2
WP_015916082.1\|1906573_1907707_+	phage protein gp27	NA	NA	NA	NA
WP_015916083.1\|1907719_1910929_+	DUF4815 domain-containing protein	K4ICQ5	Acidithiobacillus_phage	1.9e-167	36.1
WP_015916084.1\|1910938_1912096_+	hypothetical protein	A0A222YWB9	Escherichia_phage	3.9e-14	34.2
WP_041696617.1\|1912095_1912320_+	hypothetical protein	NA	NA	NA	NA
WP_015916085.1\|1912416_1913679_+\|tail	phage tail sheath protein	A0A0A8IL59	Aurantimonas_phage	1.5e-56	35.6
WP_015916086.1\|1913705_1914239_+\|tail	phage major tail tube protein	NA	NA	NA	NA
WP_015916087.1\|1914235_1914706_+\|tail	phage tail assembly protein	NA	NA	NA	NA
WP_041696618.1\|1914710_1916588_+\|tail	phage tail tape measure protein	A0A068C997	Rhizobium_phage	4.5e-68	35.4
WP_041696620.1\|1916735_1916999_-	Arc family DNA-binding protein	NA	NA	NA	NA
WP_080516977.1\|1917092_1917260_+	Arc family DNA-binding protein	NA	NA	NA	NA
WP_015916089.1\|1917310_1917619_+	hypothetical protein	NA	NA	NA	NA
WP_041696622.1\|1917615_1917888_+	hypothetical protein	NA	NA	NA	NA
WP_015916090.1\|1917884_1918676_+	Prophage antirepressor protein	R9TP95	Rhizobium_phage	1.3e-69	54.3
WP_015916091.1\|1918766_1919702_+	Rha family transcriptional regulator	S5MQL6	Escherichia_phage	3.6e-18	43.9
WP_015916092.1\|1919784_1920204_+\|tail	phage tail protein	NA	NA	NA	NA
WP_041696624.1\|1920200_1920434_+\|tail	tail protein X	NA	NA	NA	NA
WP_015916093.1\|1920433_1921447_+	hypothetical protein	A0A0A8ILC1	Aurantimonas_phage	1.7e-37	34.2
WP_041696625.1\|1921511_1921757_+	hypothetical protein	NA	NA	NA	NA
WP_015916094.1\|1921743_1922322_+	lysozyme	L7TM06	Rhizobium_phage	7.4e-30	41.2
WP_041696627.1\|1922323_1922668_+	ammonia monooxygenase	G8GWD9	Rhodobacter_phage	6.7e-39	65.4
1930559:1930574	attR	NA	NA	NA	NA

DBSCAN-SWA_6

2198036 : 2210995

uncultured_Mediterranean_phage(80.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015916331.1\|2198036_2200607_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	5.6e-61	49.8
WP_015916332.1\|2200816_2201188_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	1.4e-10	35.9
WP_015916333.1\|2201397_2202264_+	ATP-binding protein	NA	NA	NA	NA
WP_041696707.1\|2202379_2204023_-	LysM peptidoglycan-binding domain-containing M23 family metallopeptidase	S5VY01	Leptospira_phage	5.0e-07	29.4
WP_015916335.1\|2204247_2204901_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1J0MC37	Streptomyces_phage	3.0e-11	35.5
WP_015916336.1\|2204897_2205668_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	6.0e-27	32.5
WP_015916337.1\|2205802_2207086_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	2.7e-96	45.6
WP_015916338.1\|2207127_2207940_-	twin-arginine translocase subunit TatC	A0A1B1IVR7	uncultured_Mediterranean_phage	3.0e-53	46.9
WP_015916339.1\|2207936_2208887_-	twin-arginine translocase subunit TatB	NA	NA	NA	NA
WP_015916340.1\|2208981_2209197_-	twin-arginine translocase TatA/TatE family subunit	A0A1B1IVR9	uncultured_Mediterranean_phage	1.0e-08	70.5
WP_015916341.1\|2209391_2210108_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	9.7e-40	47.2
WP_041696712.1\|2210113_2210995_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	4.9e-33	34.0

DBSCAN-SWA_7

2493560 : 2528665

Ochrobactrum_phage(40.0%)

tail,protease,head,capsid,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015916573.1\|2493560_2495816_-	hypothetical protein	A0A291AUU8	Sinorhizobium_phage	5.1e-26	49.6
WP_015916574.1\|2495824_2499160_-\|tail	tail fiber protein	G8GWG0	Rhodobacter_phage	1.0e-280	45.0
WP_015916575.1\|2499156_2499576_-	C40 family peptidase	M4SRS7	Rhodobacter_phage	2.5e-27	48.9
WP_041696831.1\|2499747_2500263_-	hypothetical protein	A0A1B0T6D7	Thiobacimonas_phage	1.1e-32	47.7
WP_015916576.1\|2500259_2500682_-	hypothetical protein	A0A1B0T6E0	Thiobacimonas_phage	5.0e-36	61.4
WP_015916577.1\|2500678_2504485_-\|tail	phage tail length tape measure family protein	V9QJ75	Rhizobium_phage	5.0e-34	51.9
WP_041696833.1\|2504481_2504787_-	DUF1799 domain-containing protein	G8GWF5	Rhodobacter_phage	2.1e-12	45.7
WP_041696835.1\|2504837_2505290_-	hypothetical protein	NA	NA	NA	NA
WP_139192274.1\|2505322_2506252_-	hypothetical protein	G8GWF3	Rhodobacter_phage	1.7e-73	45.3
WP_156753170.1\|2506251_2506422_-	hypothetical protein	NA	NA	NA	NA
WP_015916581.1\|2506418_2506835_-	hypothetical protein	NA	NA	NA	NA
WP_015916582.1\|2506831_2507407_-	phage virion morphogenesis protein	A0A2K9VH22	Faecalibacterium_phage	3.8e-10	32.8
WP_015916583.1\|2507408_2507846_-	DUF1320 domain-containing protein	A0A1B0T6F3	Thiobacimonas_phage	4.1e-17	37.9
WP_015916584.1\|2507857_2508199_-	hypothetical protein	NA	NA	NA	NA
WP_015916585.1\|2508306_2509203_-\|head	Mu-like prophage major head subunit gpT family protein	M4SRT6	Rhodobacter_phage	2.1e-92	53.0
WP_015916586.1\|2509215_2509623_-	hypothetical protein	A0A1B0T6E4	Thiobacimonas_phage	1.6e-26	54.8
WP_049777203.1\|2509619_2510702_-\|protease	phage protease	A0A219VH76	Ochrobactrum_phage	4.0e-21	29.7
WP_015916588.1\|2511067_2512363_-\|capsid	minor capsid protein	A0A219VH74	Ochrobactrum_phage	1.5e-54	35.4
WP_015916589.1\|2512359_2513913_-	DUF935 domain-containing protein	A0A1B0T6F2	Thiobacimonas_phage	1.6e-108	44.0
WP_015916590.1\|2513912_2515556_-	hypothetical protein	M4SRU6	Rhodobacter_phage	4.3e-200	64.6
WP_015916591.1\|2515552_2516137_-	DUF3486 family protein	M4SNU5	Rhodobacter_phage	6.1e-40	47.9
WP_015916592.1\|2516139_2516457_-	hypothetical protein	A0A219VHE1	Ochrobactrum_phage	1.3e-17	48.5
WP_015916593.1\|2516437_2516821_-	DUF2730 family protein	A0A219VHD8	Ochrobactrum_phage	2.9e-14	41.2
WP_041696838.1\|2516817_2517036_-	TraR/DksA C4-type zinc finger protein	B5TA71	Burkholderia_phage	3.9e-08	41.8
WP_080516988.1\|2517025_2517286_-	hypothetical protein	NA	NA	NA	NA
WP_041696840.1\|2517230_2517584_-	hypothetical protein	NA	NA	NA	NA
WP_041696842.1\|2517580_2517853_-	hypothetical protein	A0A219VHD7	Ochrobactrum_phage	1.3e-13	53.4
WP_156753171.1\|2517852_2518029_-	hypothetical protein	NA	NA	NA	NA
WP_015916596.1\|2518025_2518532_-	M15 family metallopeptidase	NA	NA	NA	NA
WP_015916597.1\|2518633_2518993_-	hypothetical protein	M4SNV1	Rhodobacter_phage	1.9e-12	42.4
WP_041696845.1\|2518985_2519177_-	hypothetical protein	NA	NA	NA	NA
WP_041698105.1\|2519179_2519410_-	hypothetical protein	A0A219VHD0	Ochrobactrum_phage	1.6e-07	47.5
WP_041696847.1\|2519433_2519871_-	hypothetical protein	NA	NA	NA	NA
WP_156753172.1\|2519870_2520041_-	hypothetical protein	NA	NA	NA	NA
WP_015916600.1\|2520040_2520688_-	regulatory protein GemA	A0A219VHC6	Ochrobactrum_phage	2.6e-44	49.8
WP_015916601.1\|2520684_2520975_-	hypothetical protein	NA	NA	NA	NA
WP_041696849.1\|2520974_2521181_-	hypothetical protein	NA	NA	NA	NA
WP_041696852.1\|2521177_2521489_-	hypothetical protein	NA	NA	NA	NA
WP_041696854.1\|2521485_2521920_-	hypothetical protein	NA	NA	NA	NA
WP_015916602.1\|2521931_2522585_-	DUF3164 family protein	M4STB6	Rhodobacter_phage	1.1e-61	55.7
WP_041696856.1\|2522589_2522877_-	hypothetical protein	NA	NA	NA	NA
WP_041696860.1\|2523151_2523433_-	hypothetical protein	NA	NA	NA	NA
WP_015916603.1\|2523429_2524461_-	AAA family ATPase	A0A219VHC7	Ochrobactrum_phage	2.6e-94	52.6
WP_015916604.1\|2524498_2526571_-\|transposase	Mu transposase C-terminal domain-containing protein	A0A219VHD4	Ochrobactrum_phage	1.6e-175	63.4
WP_041696862.1\|2526567_2526771_-	hypothetical protein	NA	NA	NA	NA
WP_015916605.1\|2526770_2527232_-	hypothetical protein	A0A219VHC5	Ochrobactrum_phage	1.8e-42	53.6
WP_015916606.1\|2527228_2528056_-	ParB N-terminal domain-containing protein	A0A219VHB6	Ochrobactrum_phage	3.0e-53	46.9
WP_041696864.1\|2528048_2528315_-	hypothetical protein	NA	NA	NA	NA
WP_049777303.1\|2528314_2528665_-	hypothetical protein	A0A219VHC3	Ochrobactrum_phage	1.5e-17	42.2

DBSCAN-SWA_8

2534871 : 2555780

Ochrobactrum_phage(50.0%)

terminase,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015915598.1\|2534871_2535666_+	ATP-binding protein	A0A059NT77	Lactococcus_phage	7.0e-31	34.9
WP_015916611.1\|2536850_2538404_-	DUF935 domain-containing protein	A0A1B0T6F2	Thiobacimonas_phage	4.6e-111	44.2
WP_015916612.1\|2538403_2539762_-\|terminase	terminase	A0A2P9JZI8	Alteromonadaceae_phage	1.7e-149	60.2
WP_015916613.1\|2539758_2540358_-	DUF3486 family protein	M4SNU5	Rhodobacter_phage	4.8e-48	53.8
WP_041696869.1\|2540360_2540678_-	hypothetical protein	A0A219VHE1	Ochrobactrum_phage	4.3e-16	45.6
WP_015916614.1\|2540658_2541042_-	DUF2730 family protein	A0A219VHD8	Ochrobactrum_phage	2.2e-14	42.0
WP_015916615.1\|2541038_2541257_-	TraR/DksA C4-type zinc finger protein	NA	NA	NA	NA
WP_080516990.1\|2541246_2541504_-	hypothetical protein	NA	NA	NA	NA
WP_015916616.1\|2541451_2541805_-	hypothetical protein	NA	NA	NA	NA
WP_015916617.1\|2541801_2542074_-	hypothetical protein	A0A219VHD7	Ochrobactrum_phage	1.0e-13	51.3
WP_156753215.1\|2542073_2542250_-	hypothetical protein	NA	NA	NA	NA
WP_080517022.1\|2542246_2542753_-	M15 family metallopeptidase	NA	NA	NA	NA
WP_049777210.1\|2542853_2543255_-	hypothetical protein	M4SNV1	Rhodobacter_phage	1.6e-15	43.4
WP_015916619.1\|2543205_2543859_-	regulatory protein GemA	M4STB3	Rhodobacter_phage	8.3e-46	48.3
WP_041696873.1\|2543855_2544092_-	hypothetical protein	NA	NA	NA	NA
WP_015916620.1\|2544103_2544757_-	DUF3164 family protein	M4STB6	Rhodobacter_phage	1.1e-71	65.2
WP_041696875.1\|2544761_2545043_-	hypothetical protein	NA	NA	NA	NA
WP_041696877.1\|2545039_2545369_-	hypothetical protein	NA	NA	NA	NA
WP_041696878.1\|2545365_2545650_-	hypothetical protein	NA	NA	NA	NA
WP_015916622.1\|2545646_2546690_-	AAA family ATPase	A0A219VHC7	Ochrobactrum_phage	8.2e-96	52.4
WP_015916623.1\|2546727_2548794_-\|transposase	Mu transposase C-terminal domain-containing protein	A0A219VHD4	Ochrobactrum_phage	1.1e-176	62.5
WP_015916624.1\|2548790_2549255_-	hypothetical protein	A0A219VHC5	Ochrobactrum_phage	3.2e-44	55.8
WP_187152358.1\|2549251_2549623_-	hypothetical protein	A0A219VHB6	Ochrobactrum_phage	1.9e-15	43.9
WP_187152359.1\|2549667_2550108_-	ParB/RepB/Spo0J family partition protein	A0A219VHB6	Ochrobactrum_phage	2.9e-42	66.0
WP_015916625.1\|2550107_2550458_-	hypothetical protein	A0A219VHC3	Ochrobactrum_phage	7.4e-17	43.1
WP_139192495.1\|2550710_2550959_+	hypothetical protein	NA	NA	NA	NA
WP_041696880.1\|2550908_2551145_-	hypothetical protein	NA	NA	NA	NA
WP_015916627.1\|2551298_2551637_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_139192501.1\|2551772_2552465_+	helix-turn-helix domain-containing protein	R9U2Q5	Rhizobium_phage	1.0e-70	56.8
WP_015916629.1\|2552585_2553059_+	hypothetical protein	NA	NA	NA	NA
WP_015916630.1\|2553263_2555780_-	Hsp70 family protein	G8DDB7	Micromonas_pusilla_virus	4.2e-29	30.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

5. NC_011984

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

7499 : 79828

uncultured_Caudovirales_phage(27.27%)

integrase,transposase

attL 12849:12908|attR 55420:56895

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012650478.1\|7499_8633_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_041699298.1\|8757_9711_+	DUF1403 family protein	NA	NA	NA	NA
WP_139191523.1\|10411_10687_-	hypothetical protein	NA	NA	NA	NA
WP_012650483.1\|11139_11832_+	DUF72 domain-containing protein	D2XAQ3	Marseillevirus	9.2e-11	26.0
WP_080517069.1\|12116_12749_+	toll/interleukin-1 receptor domain-containing protein	NA	NA	NA	NA
12849:12908	attL	NA	NA	NA	NA
WP_081364425.1\|14325_15030_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_049777436.1\|14983_15280_-	hypothetical protein	NA	NA	NA	NA
WP_012650487.1\|18103_18475_-	response regulator	NA	NA	NA	NA
WP_139192311.1\|18706_19339_-	isochorismatase family protein	NA	NA	NA	NA
WP_148213982.1\|21944_22205_-\|transposase	transposase	NA	NA	NA	NA
WP_012650491.1\|23097_24783_+	Na/Pi cotransporter family protein	NA	NA	NA	NA
WP_012650492.1\|24775_25312_+	NUDIX hydrolase	A0A2H4IB87	Erwinia_phage	7.6e-05	27.9
WP_041699307.1\|25406_26123_-\|transposase	IS6 family transposase	NA	NA	NA	NA
WP_187152414.1\|26162_28283_-	PAS domain S-box protein	NA	NA	NA	NA
WP_012650495.1\|28638_29355_-\|transposase	IS6 family transposase	NA	NA	NA	NA
WP_012650496.1\|29501_29999_-	ferritin-like domain-containing protein	NA	NA	NA	NA
WP_012650497.1\|30062_30977_-	hypothetical protein	NA	NA	NA	NA
WP_071206036.1\|30994_31504_-	response regulator	NA	NA	NA	NA
WP_012650499.1\|31974_32436_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_139192543.1\|33020_34187_+	PHB depolymerase family esterase	NA	NA	NA	NA
WP_012650503.1\|35625_36870_-	type II toxin-antitoxin system HipA family toxin	NA	NA	NA	NA
WP_012650504.1\|36862_37198_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012650505.1\|37428_39786_+	hypothetical protein	NA	NA	NA	NA
WP_139191523.1\|41030_41306_+	hypothetical protein	NA	NA	NA	NA
WP_187152415.1\|42168_43692_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	1.3e-09	59.0
WP_012650490.1\|43936_44251_+\|transposase	transposase	NA	NA	NA	NA
WP_148213984.1\|44201_44717_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_012650509.1\|45004_45976_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_148213984.1\|46631_47147_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_012650490.1\|47097_47412_-\|transposase	transposase	NA	NA	NA	NA
WP_049777466.1\|48888_50595_+	carbohydrate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_187152416.1\|50721_52497_+	MCP four helix bundle domain-containing protein	A0A2H4J162	uncultured_Caudovirales_phage	3.0e-13	34.6
WP_012650515.1\|55854_58425_-	GAF domain-containing protein	B5LWN8	Feldmannia_species_virus	2.5e-21	29.1
55420:56895	attR	NA	NA	NA	NA
WP_139191369.1\|58447_59308_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012650517.1\|60361_62647_+	HAMP domain-containing protein	A0A2H4J162	uncultured_Caudovirales_phage	5.3e-15	35.6
WP_071204112.1\|64084_64909_+\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_012650518.1\|64854_65088_+	hypothetical protein	NA	NA	NA	NA
WP_015914915.1\|65068_66728_-\|transposase	IS66 family transposase	A0A0P0ZEB3	Stx2-converting_phage	1.5e-96	39.9
WP_012650519.1\|66773_67127_-	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZDM8	Stx2-converting_phage	7.4e-33	57.8
WP_015914914.1\|67123_67576_-	IS66 family insertion sequence hypothetical protein	NA	NA	NA	NA
WP_012650521.1\|67959_69096_-	hybrid sensor histidine kinase/response regulator	A0A1V0SGX0	Hokovirus	1.1e-21	31.1
WP_012650522.1\|69095_69665_-	chemotaxis protein CheB	NA	NA	NA	NA
WP_012650523.1\|69661_70495_-	chemotaxis protein CheR	NA	NA	NA	NA
WP_012650524.1\|70491_73929_-	response regulator	A0A1V0SGX0	Hokovirus	5.0e-33	28.1
WP_049777445.1\|74211_74586_+	YsnF/AvaK domain-containing protein	NA	NA	NA	NA
WP_012650526.1\|74602_75058_+	hypothetical protein	NA	NA	NA	NA
WP_012650527.1\|75090_75744_+	DUF433 domain-containing protein	NA	NA	NA	NA
WP_012650528.1\|75740_76172_+	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_012650529.1\|76206_77067_-	putative addiction module antidote protein	NA	NA	NA	NA
WP_080517071.1\|78645_78819_-	hypothetical protein	NA	NA	NA	NA
WP_085946654.1\|79067_79828_-\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	8.0e-24	43.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage