CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_009831	Shewanella sediminis HAW-EB3, complete sequence	10 crisprs	cas3,csa3,DEDDh,RT,DinG,WYL	1	1	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_009831_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009831_1

824102-824201

Orphan

Consensus_repeat	Method
GATGGCATAGATAGAGTCGTCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_009831_1

>merge|NC_009831|1|824102-824201|CRISPRCasFinder
GATGGCATAGATAGAGTCGTCGCACTGTTAGAGAGTCGGAGTCATTGTGATTGAGTGAGTATATGAATAAAGAGATAGATGGAATAGATAGAGTCGTCGC

>NC_009831|1|1|824102-824201|CRISPRCasFinder
GATGGCATAGATAGAGTCGTCGC	ACTGTTAGAGAGTCGGAGTCATTGTGATTGAGTGAGTATATGAATAAAGAGATA
GATGGAATAGATAGAGTCGTCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_009831.1\|WP_012141026.1\|818867_819392_+\|lactoylglutathione-lyase-family-protein	unknown	unknown	gnl\|CDD\|132684
NC_009831.1\|WP_012141035.1\|827788_829000_+\|NnrS-family-protein	unknown	unknown	gnl\|CDD\|377571
NC_009831.1\|WP_012141038.1\|832685_833444_+\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NC_009831.1\|WP_012141036.1\|829071_830466_+\|ammonia-forming-cytochrome-c-nitrite-reductase-subunit-c552	unknown	unknown	gnl\|CDD\|236854
NC_009831.1\|WP_012141024.1\|816688_817777_+\|cysteine-synthase-A	unknown	unknown	gnl\|CDD\|182672
NC_009831.1\|WP_012141040.1\|834111_835326_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_009831.1\|WP_012141039.1\|833447_834122_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_009831.1\|WP_012141030.1\|823040_823940_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NC_009831.1\|WP_012141027.1\|819463_820942_-\|sodium:proton-antiporter-NhaD	unknown	unknown	gnl\|CDD\|129857
NC_009831.1\|WP_150104387.1\|830657_831737_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341030
NC_009831.1\|WP_012141029.1\|821870_822764_-\|phospholipase-A	unknown	unknown	gnl\|CDD\|376748
NC_009831.1\|WP_012141032.1\|824830_825226_+\|response-regulator	unknown	unknown	gnl\|CDD\|381099
NC_009831.1\|WP_012141033.1\|825384_826449_+\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|377393
NC_009831.1\|WP_012141025.1\|817847_818732_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_009831.1\|WP_012141022.1\|814741_815125_+\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012141023.1\|815281_815836_-\|DUF2799-domain-containing-protein	unknown	unknown	gnl\|CDD\|378521
NC_009831.1\|WP_012141034.1\|826649_827111_+\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|223149
NC_009831.1\|WP_012141041.1\|835799_836546_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367531
NC_009831.1\|WP_012141028.1\|821264_821756_+\|peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|238901
NC_009831.1\|WP_012141021.1\|814259_814511_-\|DUF2999-domain-containing-protein	unknown	unknown	gnl\|CDD\|288110

Protein	Function_ID	Function_description	E-value
NC_009831.1\|WP_012141026.1\|818867_819392_+\|lactoylglutathione-lyase-family-protein	gnl\|CDD\|132684	TIGR03645, glyox_marine, lactoylglutathione lyase family protein. Members of this protein family share homology with lactoylglutathione lyase (glyoxalase I) and are found mainly in marine members of the gammaproteobacteria, including CPS_0532 from Colwellia psychrerythraea 34H. This family excludes a well-separated, more narrowly distributed paralogous family, exemplified by CPS_3492 from C. psychrerythraea. The function is of this protein family is unknown.	1.90318e-126
NC_009831.1\|WP_012141035.1\|827788_829000_+\|NnrS-family-protein	gnl\|CDD\|377571	pfam05940, NnrS, NnrS protein. This family consists of several bacterial NnrS like proteins. NnrS is a putative heme-Cu protein (NnrS) and a member of the short-chain dehydrogenase family. Expression of nnrS is dependent on the transcriptional regulator NnrR, which also regulates expression of genes required for the reduction of nitrite to nitrous oxide, including nirK and nor. NnrS is a haem- and copper-containing membrane protein. Genes encoding putative orthologues of NnrS are sometimes but not always found in bacteria encoding nitrite and/or nitric oxide reductase.	2.30577e-93
NC_009831.1\|WP_012141038.1\|832685_833444_+\|LuxR-family-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	2.21352e-09
NC_009831.1\|WP_012141024.1\|816688_817777_+\|cysteine-synthase-A	gnl\|CDD\|182672	PRK10717, PRK10717, cysteine synthase A; Provisional.	0
NC_009831.1\|WP_012141040.1\|834111_835326_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.90492e-13
NC_009831.1\|WP_012141039.1\|833447_834122_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.83595e-64
NC_009831.1\|WP_012141030.1\|823040_823940_-\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.05182e-21
NC_009831.1\|WP_012141027.1\|819463_820942_-\|sodium:proton-antiporter-NhaD	gnl\|CDD\|129857	TIGR00775, CT857_hypothetical_protein, Na+/H+ antiporter, NhaD family. These proteins are members of the NhaD Na+:H+ Antiporter (NhaD) Family (TC 2.A.62). A single member of the NhaD family has been characterized. This protein is the NhaD protein of Vibrio parahaemolyticus which has 12 GES predicted transmembrane regions. It has been shown to catalyze Na+/H+ antiport, but Li+ can also be a substrate. [Transport and binding proteins, Cations and iron carrying compounds].	1.82714e-127
NC_009831.1\|WP_150104387.1\|830657_831737_-\|MFS-transporter	gnl\|CDD\|341030	cd17477, MFS_YcaD_like, YcaD and similar transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.24204e-66
NC_009831.1\|WP_012141029.1\|821870_822764_-\|phospholipase-A	gnl\|CDD\|376748	pfam02253, PLA1, Phospholipase A1. Phospholipase A1 is a bacterial outer membrane bound acyl hydrolase with a broad substrate specificity EC:3.1.1.32. It has been proposed that Ser164 is the active site for Escherichia coli phospholipase A1.	3.59142e-140
NC_009831.1\|WP_012141032.1\|824830_825226_+\|response-regulator	gnl\|CDD\|381099	cd17546, REC_hyHK_CKI1_RcsC-like, phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC. This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.71962e-19
NC_009831.1\|WP_012141033.1\|825384_826449_+\|FUSC-family-protein	gnl\|CDD\|377393	pfam04632, FUSC, Fusaric acid resistance protein family. This family includes a conserved region found in two proteins associated with fusaric acid resistance, FusC from Burkholderia cepacia and fdt-2 from Klebsiella oxytoca. These proteins are likely to be membrane transporter proteins.	2.77473e-19
NC_009831.1\|WP_012141025.1\|817847_818732_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	3.51407e-34
NC_009831.1\|WP_012141036.1\|829071_830466_+\|ammonia-forming-cytochrome-c-nitrite-reductase-subunit-c552	gnl\|CDD\|236854	PRK11125, nrfA, ammonia-forming cytochrome c nitrite reductase.	3.25998e-161
NC_009831.1\|WP_012141023.1\|815281_815836_-\|DUF2799-domain-containing-protein	gnl\|CDD\|378521	pfam10973, DUF2799, Protein of unknown function (DUF2799). Some members in this family of proteins are annotated as yfiL which has no known function.	1.06213e-27
NC_009831.1\|WP_012141034.1\|826649_827111_+\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	9.60806e-30
NC_009831.1\|WP_012141041.1\|835799_836546_+\|hypothetical-protein	gnl\|CDD\|367531	pfam03502, Channel_Tsx, Nucleoside-specific channel-forming protein, Tsx.	9.48886e-28
NC_009831.1\|WP_012141028.1\|821264_821756_+\|peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|238901	cd01920, cyclophilin_EcCYP_like, cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these have reduced affinity for cyclosporin A. E. coli cyclophilin A has a similar peptidylprolyl cis- trans isomerase activity to the human cyclophilin A. Most members of this subfamily contain a phenylalanine residue at the position equivalent to Human cyclophilin W121, where a tyrptophan has been shown to be important for cyclophilin binding.	6.84687e-73
NC_009831.1\|WP_012141021.1\|814259_814511_-\|DUF2999-domain-containing-protein	gnl\|CDD\|288110	pfam11212, DUF2999, Protein of unknown function (DUF2999). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	2.22015e-39

>NC_009831.1|WP_012141030.1|823040_823940_-|EamA-family-transporter
MNILLAMIPAFFWGTTYAVTQYTLPDWPPLLLGALRALPAGLLLLAIKPSMPKRSEWGVLFRLGLINIAAFFSLIFVMALTLPSAISGVGMISVPVFAMLYHWAVNKRRPNAIQAFFGLVLIVLAWLLFDPGSISLSPVGLMALLAAILCIVIGSSITKSLADRIHWWSILTWQLIIGGTLLAIAAAVHALFSPGTYLEAVQGFSSANGAGLLWITLLNTVLGYIMYVWLLQRMTVVDFTFGGIANPIAGIVSGMVLLNESFSPHQYLLMAGMILTSLLPQIIQLIRNRKPHSVAVKSS
>NC_009831.1|WP_012141029.1|821870_822764_-|phospholipase-A
MTIYRSCIMLVFLAITSLTVHAEDSLVESRLKDELLTSELPFVITPHKVNYILFASYNDNPNIEPFLPEAEQQEIEPVIDNVEAKFQISFKFPLMYNVFGDNGHLFVAYTNQSYWQVYNKDISSPFRETNHEPEIFMLFNNDWEIAGMTNSFWGVGAVHQSNGQTPSRSRSWNRIYGTMIFDGGPFALAGKVWWRIPEDEKEYPEDPRGDDNPDIEDYMGNFELSGVYGLDEHRFTMMLRNNLSSPNYGAVELTWSYPIMGNLRLYTQYFNGYGESLIDYNAHTQRIGIGVSINDIL
>NC_009831.1|WP_012141028.1|821264_821756_+|peptidyl-prolyl-cis-trans-isomerase
MIIFTTNIGDITIELDVDNAPVSAKNFLRYCQDGFYEGTIFHRVIKGFMVQGGGLTADMDEKPTRAAIVNEANRGLKNVVGSIAMARTDAPHSATGQFFINLANNSFLDHTATTNAGWGYAVFGKVTAGMDVIKKIEKAKTTSVAGHDDVPREPIVIERVTVI
>NC_009831.1|WP_012141027.1|819463_820942_-|sodium:proton-antiporter-NhaD
MKSIRPFRGSVAASQLAKFLLFLAVLFSPSVFASTSGSSGQLLDLTATTAGYLALFIFVFSYLLVMGEEVIHLRKSKPVLVAAGLIWGIIGFIYVQNGMSELSEAAFKHNLLDYAELFLFLLVAMTYINAMEERQLFDALRAWMIGRGFSLRTVFWLTGFMSFFISPIADNLTTALLMCAVVMKVGGINHKFISLACINIVIAANAGGAFSPFGDITTLMVWQKGVVQFSQFIDLFIPSLVNYIVPAIIMSLFVVNRTQKVQEEKVIMKRGAKRIVALFLLTIATAVCTHTFLGLPPVLGMMTGLGFLQFFGFFLRMTFDKSVAKKRKLAERAQDEKRLTYLGHVVPFDVFTRIARAEWDTLLFFYGVVLCVGGLGFMGYLSLVSEAMYTHWDVTYANIAIGVLSAIVDNIPVMFAVLTMNPDMGLGQWLLVTLTAGVGGSLLSIGSAAGVALMGQAHGVYTFAAHLKWTPVIALGYAASILVHLWLNASLF
>NC_009831.1|WP_012141026.1|818867_819392_+|lactoylglutathione-lyase-family-protein
MSMLTPQSSPYPRTFSHIGISVPDLEAAVKFYTQVLGWYLIMEPTEVIEDDSAIGEMCTDVFGAGWERFRIAHLSTGDRIGVELFEFKNQENPEDNFEYWKTGIFHFCVQDPNVEELAEKIVAAGGKKRMKAPRYYYPGEKPYRMIYMEDPFGNILEIYSHSYELHYSSGAYND
>NC_009831.1|WP_012141025.1|817847_818732_-|LysR-family-transcriptional-regulator
MLNPLWLNTFKTLIDLGHFTRTAEKLHMTQPGVSQQIQKLEKACGHSLIKREKKSFELTEQGRLVYGYALKIAEDEANLIETLGFDNPYAGQCKLSCSGSQALQLYPALLSLQLQHPELSVQLEAAPNQKILHDLQSGKIDLGIVTHTPESGLYRSTVIGEETLCLVLPKQYENRGIDPERLIECGLIDHPDAKHYLSLYFEHCGEKALAKMSQDEVPKSGYINQVNQILLPVAKGLGFTVLPESAVKNFPLRDKLYIAHTAKQVKETLYLVQKRNRNLPSRYQTVSQLLRSII
>NC_009831.1|WP_012141024.1|816688_817777_+|cysteine-synthase-A
MKSSPHSQERPLTLSPVLGNVTQLIGNTDLLRINSISDLTGCEILLKCEQQNPGGSIKDRAALQMVQDAIFSGKLKPGMTIVEGTAGNTGIGLALVAKALRFKMLVVMPRGQAPEKEQMINLYGAELLLVDACPFANPNHFYHTAKRIAEGNDNYWWADQFENTSNSKAHYEHTGPEIWQQTQGEIDALVSVAGTGGTIAGNSRYLSEMHHGLKTWLVDPDGSGIYAYLKTGQYVSSGSSFTEGIGIMRSVENFRQAKVDKAITLPDRDLIAIARHVRECDGIALGSSSALNVAGALYAAAKMGAGKTIVTFCCDLAERSSSKLYNEDFLVEKGFSESCESIEEMFERYQNEPAEAVVDVHR
>NC_009831.1|WP_012141023.1|815281_815836_-|DUF2799-domain-containing-protein
MKFKIFAAIAALSLTQCTSLNLEQCKHSDWYSLGMTDGNSGSASSTLNGYIEDCREFGLGVNTEQWTAGYRAGLENYCQPENGYKLGLQGSYYNGVCANNEFVKRYNEGHRQFEIKNKIARIQSRLKDIERELTQVNKKIHAKQDVASNKEDKKSLKNERHDLEKELMLLRIGAADILPIQLLF
>NC_009831.1|WP_012141022.1|814741_815125_+|hypothetical-protein
MSDQFICWHCGNVLEEVILPMSRREGCGACGADQHVCKMCVFFNDSGRGDCREERAEWVSDRERANFCDYFKLSEGGTDTYAPGANEQALAELAELFGDTPPSEPDEKEKEMTPAEIAEKQLRDLLG
>NC_009831.1|WP_012141021.1|814259_814511_-|DUF2999-domain-containing-protein
MNPILAILKEHNVSDTQINELFQTLTENPLMAMGTIGQLGIPPEKLQQLMALVMQNPALIKEAVEELGLDFSKVEAAKAQLQQ
>NC_009831.1|WP_012141032.1|824830_825226_+|response-regulator
MRILIADDDKVSRNINRDILSLSGSVDAVVNGAEAVQIFKTALHENDPYELICLDISMPFFDGMYALEEIRSLERAKMISPEKSVKIVMVTSSSDRRDILNVRGKCNGYLLKPLSTGSMEKLLNRFKELKH
>NC_009831.1|WP_012141033.1|825384_826449_+|FUSC-family-protein
MSVFSPATPFANYIYRHFRAIHALKLGLALLIAVIINAFWAQPHFVWSMVTIVIIMMSLPQVGGAIEKSMQRAVGTCIGSAYGVMLVVSFQNYWLLMGLLILGVSLTCFISAGRYSYAYLVAGFTMIIVIGDANHDTFEALWRTANILLGCFIAVLVSLFVFPIKAKQDWRSQLAHSTNILAVILDKHFTASMKEPFDARPELESAMKAVLTQKKLFFSLEWESKTLKQYKSVLTHLVNKQIRVITLLELLLQTRWTDEDSASYAKVNQVALILQSSLLELSEFLTGRRTDFPALPEKMAINLHQELLASLDRDEQQEFSLTGYSWLIYQLAKTIESIYAEVDVISQAYERKRR
>NC_009831.1|WP_012141034.1|826649_827111_+|Hsp20/alpha-crystallin-family-protein
MKSFFPSIFHRDDPRSAMDNIFNDFSREWLSSWPNSRLDKHHVIPAIDVKEYGEYFEIKAELPDMNEKDIEVDIQGTYLSIRGEKKYEQESDEKGYHLRERSFGTFHRQIPLGFNVDVELVTAKYAKGVLSIHVPKPVEMQHDVKKIKVKFEE
>NC_009831.1|WP_012141035.1|827788_829000_+|NnrS-family-protein
MINIDDPAAVEKTPAIWRLGFRPFFLGGASIAMLYIPLWLVTWFLPQYSLFQSEFWVKVVPLWWHPHEMLFGFALAIVCGFLLTSVQTWTNQPGMKGWPLAVTFGCWLSARLLLLAPFEIPLWLPALFDSLFLAFTAIKLWRCIYKVKQWHNIGFPIMLAVALGINLLSYYALSERNFTLSNHIWQAMLWWLGLLITIVGGRVIPFFTAIKIKQTKPTPIAVIERSLIVLMALLVVQAITKMMPSALEQVLLIAAGALHLARWLRWFPHKTLKEPMLWSLHSAYIFLPITLFALAWNVNDLNAYRHLLHLFAIGTLAGICLSMISRVSLGHTSRNIYEGPKMAIAFICLPIAAIFRAVIPLFLPEQSQLWLWLAGSFWSVAFGMFVWNYATILCSPRADGRPG
>NC_009831.1|WP_012141036.1|829071_830466_+|ammonia-forming-cytochrome-c-nitrite-reductase-subunit-c552
MISIQSNKVKALSVLSLCLSVFAVSLPASAGAVDAKLDNAMQEQFPNQYKSWLATSEQTERQDMLASYPAAIILWAGSSFAKEYHSPRGHHFAVADVTHTLRTGVAVAEGEKGLSASCWTCKSPDVPRLIGELGVEGFSAKNFTDLGTEIQSVVYCTDCHVKGSAKLALPRPHAQDAMTKAHIPFDKQDINMQGAQVCGQCHVSYYFQPERSNKVNIPWIFGNNADDIEKYYDTRRFYEWIHPISKTPILKARHPEFEHWSRSEHAKQGVTCITCHMPATSDDKGNQFTSHKVSKALEHYPQACQGCHGDKAALMQTLETGKHEIEAKAREVEGLLVKAHYEAQAAWDAGATWPIINDALMAIRHSQWRWDFAMASHGLYAHNPSEGRELLDTAIEQAKYARTSLAEILKMLEVKEVNYPDISTKESAQKAVGISLDTLTEQKKAFLKEEVDKHWSEVSRHGYE
>NC_009831.1|WP_150104387.1|830657_831737_-|MFS-transporter
MSLIPLSLPSFGLSESLVPWLASIFYLGILIGATSIQNLVSRTGHRIALIIFLSTLILTIIAMLLVPDAGVWLIARFVAGFAVAGIFVVIESWLLMADSSKQRAKRLGLYMTSLYGGSALGQLAIAPIGISGIAPYLTVIFLLMLAILPPLLIKRGQPSCEQHQKVKLCELRGMSRPAILGCLASGLLLGPIYGLMPVYISSQVQSADQTGMLMAVIILGGMLVQPLVSHLSSRVSKSLLMALFCLFGTLGVVGVLEAQNFVIIATSYLVLGACSFALYPIAITLACDALPVAKIVSATEIMLLSYSVGSVLGPLFAANLSDSPDGIIFYLGGCLITTCIYMLIKSMQKTHSEQWPLSQ
>NC_009831.1|WP_012141038.1|832685_833444_+|LuxR-family-transcriptional-regulator
MEKLTRLSGHETAKSSPLAESILNNIKLPIAEHGFGGFWFQGIANSAYQDYMQNSRKSLLTRRVLRSRGGVFASSPTVQQLHEQYVTRVAPTDINFGEALRLESPYCYVLCENEKPNKAKKLFNRHGVNTVMSWPLRHFASDAWGGRFTLLSKHPQGEINLIGLEATLKQAQMSLFEHFHNEINPYRQNNLFNQTAIKALKMAATGLHNYEISQELHITVRGVEYHLESMRNKLSASNRANLVHIAHQLEII
>NC_009831.1|WP_012141039.1|833447_834122_+|response-regulator-transcription-factor
MLVLLVEDNRLLAKNIIHYLELNEIECDYAETLAQAELAIFSRTFDAIILDLNLPDGDGITACKKWKEQRIISPIIMLTARSNLQDRLSGFEVGADDYLVKPFAMAELVARLRVVSQRRPSPKLLSIGELELDFAGHHAHRQGQLLTLSRTGWQILTLLARRSPEIVEREEIERLLWPDSLPDSDSLRSHIHLLRKIVDKPFEQKLIHTIRGVGLCLKVDTDET
>NC_009831.1|WP_012141040.1|834111_835326_+|HAMP-domain-containing-histidine-kinase
MKPKLSLKRVYQVYGLCFLAITLIINSFIPLCMMCTGMFSMHDITMSNAAQAAALYTSPRNNLFQTDNITVFPNWESVPERVKAINGGVAPDKPQNVKHQHTDGQFIDALMLHQGQEGQESYVWLHYNATHDLEFAPKNMAAILLLVIMTFTVNAILAWYLQSRVISPVHEISRAIKQHDWQKMQQLRFPKQCYAELQSIVDALDSSIKQLKEAQQRELSFLRFASHELRTPIAICQSSFDILTLQQGKLTGPTLHASQATTQMKSITETLLWLMSSDCSPMNSSNVKLASLLESIIYDQKYAQGSDVPVELKCDETELFVLKEPLTIVLNNLVRNSLEHGAKGISIVQAGNRIDIVNPLSLHNSSGFGLGLMLVERLAKQLNWHYSTSNDHNSFRATLIIRPS
>NC_009831.1|WP_012141041.1|835799_836546_+|hypothetical-protein
MKKQLATALAALVMAPAMSATSVDLGYKAYTSDTKSDNGGAYDQPFVKLTHFNKADWGTLLAYVKLENPGEVKDAQHGKDGKLTVKSLLIVDKQIGDTSYNFWGQNFLVSNRTVMEDNLYLGVTTNRKYGALFINAGVGLNYSAAHFDPTGASFDGISGYAAVINARYPFSAMGLKHSLSVNYEGQIDRDEDHMSTLGYDSYGHQIITTLKTSMTESFYTKLHMTHFDSWGAAPNDGIEYGVAVGFTF

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Crispr_ID: NC_009831_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009831_2

1811036-1811167

Orphan

Consensus_repeat	Method
AGTCTATAACTCATGCTCAACATGATGAGGTGTGCGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_009831_2

>merge|NC_009831|2|1811036-1811167|CRISPRCasFinder
AGTCTATAACTCATGCTCAACATGATGAGGTGTGCGGTGATAGGTCATAGAGCTGGCTGTTTGAGCCTGGCTCTATAACCTTTTTCACAACTACAGTCTGTAACTCATGCTCAACATGATGAGGTGTGCGGT

>NC_009831|2|2|1811036-1811167|CRISPRCasFinder
AGTCTATAACTCATGCTCAACATGATGAGGTGTGCGGT	GATAGGTCATAGAGCTGGCTGTTTGAGCCTGGCTCTATAACCTTTTTCACAACTAC
AGTCTGTAACTCATGCTCAACATGATGAGGTGTGCGGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_009831.1\|WP_012141865.1\|1806056_1807214_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|226355
NC_009831.1\|WP_012141872.1\|1814333_1816316_-\|OmcA/MtrC-family-decaheme-c-type-cytochrome	unknown	unknown	gnl\|CDD\|274617
NC_009831.1\|WP_012141862.1\|1802494_1803343_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_009831.1\|WP_012141871.1\|1813252_1814254_-\|DmsE-family-decaheme-c-type-cytochrome	unknown	unknown	gnl\|CDD\|274618
NC_009831.1\|WP_041421593.1\|1807413_1808187_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012141867.1\|1808365_1809337_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_009831.1\|WP_012141876.1\|1823756_1825892_-\|MtrB/PioB-family-decaheme-associated-outer-membrane-protein	unknown	unknown	gnl\|CDD\|371763
NC_009831.1\|WP_012141878.1\|1827300_1827555_+\|ferrous-iron-transport-protein-A	unknown	unknown	gnl\|CDD\|377199
NC_009831.1\|WP_012141874.1\|1819447_1821616_-\|OmcA/MtrC-family-decaheme-c-type-cytochrome	unknown	unknown	gnl\|CDD\|274617
NC_009831.1\|WP_150104398.1\|1803410_1803737_-\|QacE-family-quaternary-ammonium-compound-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|137367
NC_009831.1\|WP_012141868.1\|1809478_1810123_-\|uracil-DNA-glycosylase-family-protein	unknown	unknown	gnl\|CDD\|381683
NC_009831.1\|WP_012141864.1\|1804266_1806015_+\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NC_009831.1\|WP_012141879.1\|1827547_1829842_+\|Fe(2+)-transporter-permease-subunit-FeoB	unknown	unknown	gnl\|CDD\|223447
NC_009831.1\|WP_012141873.1\|1816750_1818967_-\|OmcA/MtrC-family-decaheme-c-type-cytochrome	unknown	unknown	gnl\|CDD\|274617
NC_009831.1\|WP_041422047.1\|1825907_1826870_-\|DmsE-family-decaheme-c-type-cytochrome	unknown	unknown	gnl\|CDD\|274618
NC_009831.1\|WP_012141861.1\|1801988_1802438_+\|GFA-family-protein	unknown	unknown	gnl\|CDD\|368144
NC_009831.1\|WP_041421594.1\|1821681_1823619_-\|OmcA/MtrC-family-decaheme-c-type-cytochrome	unknown	unknown	gnl\|CDD\|274617
NC_009831.1\|WP_041422044.1\|1810166_1810763_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012141880.1\|1830004_1831675_+\|glutamine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235424
NC_009831.1\|WP_012141860.1\|1800733_1801831_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187673

Protein	Function_ID	Function_description	E-value
NC_009831.1\|WP_012141872.1\|1814333_1816316_-\|OmcA/MtrC-family-decaheme-c-type-cytochrome	gnl\|CDD\|274617	TIGR03507, decahem_SO1788, decaheme c-type cytochrome, OmcA/MtrC family. The protein SO_1778 (MtrC) of Shewanella oneidensis MR-1, and its paralog SO_1779 (OmcA), with which it intteracts, are large decaheme proteins, about 900 amino acids in length, involved in the use of manganese [Mn(III/IV)] and iron [Fe(III)] as terminal electron acceptors. This model represents these and similar decaheme proteins, found also in Rhodoferax ferrireducens DSM 15236, Aeromonas hydrophila ATCC7966, and a few other bacterial species. [Energy metabolism, Electron transport].	1.20878e-88
NC_009831.1\|WP_012141862.1\|1802494_1803343_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	7.5634e-42
NC_009831.1\|WP_012141871.1\|1813252_1814254_-\|DmsE-family-decaheme-c-type-cytochrome	gnl\|CDD\|274618	TIGR03508, decahem_SO, decaheme c-type cytochrome, DmsE family. Members of this family are small, decaheme c-type cytochromes, related DmsE of Shewanella oneidensis MR-1, which has been shown to be part of an anaerobic dimethyl sulfoxide reductase.	9.54096e-130
NC_009831.1\|WP_012141867.1\|1808365_1809337_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	9.42602e-46
NC_009831.1\|WP_012141876.1\|1823756_1825892_-\|MtrB/PioB-family-decaheme-associated-outer-membrane-protein	gnl\|CDD\|371763	pfam11854, MtrB_PioB, Putative outer membrane beta-barrel porin, MtrB/PioB. MtrB-PioB is a family of bacterial putative outer membrane porins. This family, is secreted as part of the pio (phototrophic iron oxidation) operon that has been found to couple the oxidation of ferrous iron [Fe(II)] to reductive CO2 fixation using light energy. PioABC is found in Rhodopseudomonas palustris and MtrB-PioB is likely to be a beta-barrel porin. Similar to other outer membrane porins, PioB and MtrB are predicted to have long loops protruding into the extracellular space and short turns on the periplasmic side.	0
NC_009831.1\|WP_012141878.1\|1827300_1827555_+\|ferrous-iron-transport-protein-A	gnl\|CDD\|377199	pfam04023, FeoA, FeoA domain. This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	6.36172e-15
NC_009831.1\|WP_012141874.1\|1819447_1821616_-\|OmcA/MtrC-family-decaheme-c-type-cytochrome	gnl\|CDD\|274617	TIGR03507, decahem_SO1788, decaheme c-type cytochrome, OmcA/MtrC family. The protein SO_1778 (MtrC) of Shewanella oneidensis MR-1, and its paralog SO_1779 (OmcA), with which it intteracts, are large decaheme proteins, about 900 amino acids in length, involved in the use of manganese [Mn(III/IV)] and iron [Fe(III)] as terminal electron acceptors. This model represents these and similar decaheme proteins, found also in Rhodoferax ferrireducens DSM 15236, Aeromonas hydrophila ATCC7966, and a few other bacterial species. [Energy metabolism, Electron transport].	2.42567e-127
NC_009831.1\|WP_150104398.1\|1803410_1803737_-\|QacE-family-quaternary-ammonium-compound-efflux-SMR-transporter	gnl\|CDD\|137367	PRK09541, emrE, EmrE family multidrug efflux SMR transporter.	4.50839e-23
NC_009831.1\|WP_012141868.1\|1809478_1810123_-\|uracil-DNA-glycosylase-family-protein	gnl\|CDD\|381683	cd10033, UDG_like, uncharacterized family of the uracil-DNA glycosylase superfamily. Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Uracil may arise from mis-incorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations; thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other. UDG family 1 is the most efficient uracil-DNA glycosylase (UDG, also known as UNG) and shows a specificity for uracil in DNA. UDG family 2 includes thymine DNA glycosylase which removes uracil and thymine from G:U and G:T mismatches, and mismatch-specific uracil DNA glycosylase (MUG) which in Escherichia coli is highly specific to G:U mismatches but also repairs G:T mismatches at high enzyme concentration. UDG family 3 includes Human SMUG1 which can remove uracil and its oxidized pyrimidine derivatives from, single-stranded DNA and double-stranded DNA with a preference for single-stranded DNA. Pedobacter heparinus SMUG2, which is UDG family 3 SMUG1-like, displays catalytic activities towards DNA containing uracil or hypoxanthine/xanthine. UDG family 4 includes Thermotoga maritima TTUDGA, a robust UDG which like family 1, acts on double-stranded and single-stranded uracil-containing DNA. UDG family 5 (UDGb) includes Thermus thermophilus HB8 TTUDGB which acts on double-stranded uracil-containing DNA; it is a hypoxanthine DNA glycosylase acting on double-stranded hypoxanthine-containing DNA except for the C/I base pair, as well as a xanthine DNA glycosylase which acts on both double-stranded and single-stranded xanthine-containing DNA. UDG family 6 hypoxanthine-DNA glycosylase lacks any detectable UDG activity; it excises hypoxanthine. Other UDG families include one represented by Bradyrhizobium diazoefficiens Blr0248 which prefers single-stranded DNA and removes uracil, 5-hydroxymethyl-uracil or xanthine from it.	7.24842e-89
NC_009831.1\|WP_012141864.1\|1804266_1806015_+\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NC_009831.1\|WP_012141879.1\|1827547_1829842_+\|Fe(2+)-transporter-permease-subunit-FeoB	gnl\|CDD\|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	0
NC_009831.1\|WP_012141873.1\|1816750_1818967_-\|OmcA/MtrC-family-decaheme-c-type-cytochrome	gnl\|CDD\|274617	TIGR03507, decahem_SO1788, decaheme c-type cytochrome, OmcA/MtrC family. The protein SO_1778 (MtrC) of Shewanella oneidensis MR-1, and its paralog SO_1779 (OmcA), with which it intteracts, are large decaheme proteins, about 900 amino acids in length, involved in the use of manganese [Mn(III/IV)] and iron [Fe(III)] as terminal electron acceptors. This model represents these and similar decaheme proteins, found also in Rhodoferax ferrireducens DSM 15236, Aeromonas hydrophila ATCC7966, and a few other bacterial species. [Energy metabolism, Electron transport].	4.85305e-129
NC_009831.1\|WP_041422047.1\|1825907_1826870_-\|DmsE-family-decaheme-c-type-cytochrome	gnl\|CDD\|274618	TIGR03508, decahem_SO, decaheme c-type cytochrome, DmsE family. Members of this family are small, decaheme c-type cytochromes, related DmsE of Shewanella oneidensis MR-1, which has been shown to be part of an anaerobic dimethyl sulfoxide reductase.	2.85075e-118
NC_009831.1\|WP_012141861.1\|1801988_1802438_+\|GFA-family-protein	gnl\|CDD\|368144	pfam04828, GFA, Glutathione-dependent formaldehyde-activating enzyme. The GFA enzyme catalyzes the first step in the detoxification of formaldehyde. This domain has a beta-tent fold.	1.62645e-21
NC_009831.1\|WP_041421594.1\|1821681_1823619_-\|OmcA/MtrC-family-decaheme-c-type-cytochrome	gnl\|CDD\|274617	TIGR03507, decahem_SO1788, decaheme c-type cytochrome, OmcA/MtrC family. The protein SO_1778 (MtrC) of Shewanella oneidensis MR-1, and its paralog SO_1779 (OmcA), with which it intteracts, are large decaheme proteins, about 900 amino acids in length, involved in the use of manganese [Mn(III/IV)] and iron [Fe(III)] as terminal electron acceptors. This model represents these and similar decaheme proteins, found also in Rhodoferax ferrireducens DSM 15236, Aeromonas hydrophila ATCC7966, and a few other bacterial species. [Energy metabolism, Electron transport].	2.53938e-143
NC_009831.1\|WP_012141865.1\|1806056_1807214_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|226355	COG3835, CdaR, Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms].	4.31253e-132
NC_009831.1\|WP_012141880.1\|1830004_1831675_+\|glutamine--tRNA-ligase	gnl\|CDD\|235424	PRK05347, PRK05347, glutaminyl-tRNA synthetase; Provisional.	0
NC_009831.1\|WP_012141860.1\|1800733_1801831_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187673	cd09813, 3b-HSD-NSDHL-like_SDR_e, human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs. This subgroup includes human NSDHL and related proteins. These proteins have the characteristic active site tetrad of extended SDRs, and also have a close match to their NAD(P)-binding motif. Human NSDHL is a 3beta-hydroxysteroid dehydrogenase (3 beta-HSD) which functions in the cholesterol biosynthetic pathway. 3 beta-HSD catalyzes the oxidative conversion of delta 5-3 beta-hydroxysteroids to the delta 4-3-keto configuration; this activity is essential for the biosynthesis of all classes of hormonal steroids. Mutations in the gene encoding NSDHL cause CHILD syndrome (congenital hemidysplasia with ichthyosiform nevus and limb defects), an X-linked dominant, male-lethal trait. This subgroup also includes an unusual bifunctional [3beta-hydroxysteroid dehydrogenase (3b-HSD)/C-4 decarboxylase from Arabidopsis thaliana, and Saccharomyces cerevisiae ERG26, a 3b-HSD/C-4 decarboxylase, involved in the synthesis of ergosterol, the major sterol of yeast. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid sythase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.46788e-80

>NC_009831.1|WP_041422044.1|1810166_1810763_-|hypothetical-protein
MKIISSAINTQRISISALLLLIPTPAFAFSAAGSTATAFIILVLGGFTLLNLILNALFFFAGKYQSQRFSKIHTLCSLIIPLIALALTVMDHRGFADIAFNIGLIIVAIALALLPLQLTLNGRAPTPYGPMILSLGAFLFLAIAYLIPPVALFAALVAHVALQSQPDTKARIISFSALIIGYPLMAYWLYQTLQMFTS
>NC_009831.1|WP_012141868.1|1809478_1810123_-|uracil-DNA-glycosylase-family-protein
MALSNSDTLDALINQISACQLCRAELPYPPKPIIQVSADAKILIAGQAPGQKAHEQGLPFKDVSGDRLRSWLGVTSSQFYDPNLFAILPMGFCFPGNIIRNGKKAGDKPPIPLCAKSWRQAILSHLDKVELTVILGQYAIDYHLDNDTPDSDKCSKKSSKISVTSAVASWKQYWPSQIVLPHPSPRNNIWLKRHPEFETEILPQLKLRVKSIIS
>NC_009831.1|WP_012141867.1|1808365_1809337_-|GGDEF-domain-containing-protein
MPGKTLPPYPYSSILNLEIEEIDWQRWQRLVNTVADMFNAPATFINQANLKGIEVIIASEKPETHYHPGSSNLNSNIYCHQVVKNHSKLYVRDAKLDPQWSDNPEYTEDNYVSYLGLPISWPDGSVFGTLCVLDTKVTNYPQTYINALGVIKEVVDSDLRHLYKENQLLTLSYTDPLTQVFNRRGFSDLLRSTQELAHRLNRKLILLYFDLDEFKHANDTFGHDIGDIMLKTFAKTLKKNSRSCDLVARWGGDEFIVLIHAESESCVNLFTNRMNDLLTEQNLQPEIKYSYGYAVINPDEKMELEDLLKIADDYMYQNKLNKK
>NC_009831.1|WP_041421593.1|1807413_1808187_-|hypothetical-protein
MASPLRNTFLVLFIGSILMACGGGGANSQTTTTPEKSSTHEFRADVINLISSPDTARLNSKVDLFYKNAGIDEVEIASNLDYQQKKSTSSFGWKGLPKANLIFTIKDSYNNQSVLSTTTMEFNSAQPNFFLLAMGKTSGLEKRTLHRINKLDGALNSYRFTHANALDPRSVDIYDVDTKQALVLNLSFNHTSGVHVYDEGLAETSVIVIPSGTQPSFSNTSNYLVQTSLSHLGSNHLNVLIANPDSPSIWSLKQYSE
>NC_009831.1|WP_012141865.1|1806056_1807214_-|helix-turn-helix-domain-containing-protein
MYFLDSSLAQQIVVRTMKIIAHNINVMNHHGIILGSGDPHRIGATHEGALLAISQNRTVEITAATASDLHGVKAGINLPLHYKGEIIGVIGITGEPECLRSYGELLKMTAELIVEQANSLELTLWQYRQKEEFIFQLIKSENGFSTHLLDWAAQLGIDLSEPRVAAVIQVQGDTEQTSANSILKKVLNLLENPSRGNLVAMTSMTELVILKPAFLDGKQWDPELESLRIDKLLTRIPKEMNVRLKIALGHFFPNAADISRSYQTAKETLDAGKLLRPDESKYLYEDFSLLVLLSGLKGDWRGQELTTPYQALLNADKNGQLNKTLSVYLQHFGDQQLCANTLFIHRNTLRYRLEKIQQITGVNIQELDGLLQLYLGQVLVATRPV
>NC_009831.1|WP_012141864.1|1804266_1806015_+|phospho-sugar-mutase
MDTQLKFKIKNWLENDPDPRTKQELQGLIDANDETELGHRFSGRLVFGTAGLRGVVGAGPMRMNRLVVQQTSAGLGMYLKHQTRDVETRGVVIGYDGRHDSKQFAHDAAAVLTAMGIKVYLTSEVAATPLVAFGVTHFGAAAGIVVTASHNPPEYNGYKVYWGNGAQIIPPHDSGIAACIDRAATQAIVMQELEKTIADNSLTMLEADFYEAYRQGVRTAEILQNHTRPDLVSLSYTAMHGVGAKMAETVLKDAGVTQVYSVATQREPDGDFPTVKFPNPEEKGAMDRVIAEAKKHHTLLACANDPDADRFAVAVRKGEYESKDESAKGEYQMLTGDQVGVLLGHYLLTHAASSQRLTCTTIVSSSLLSKVAASFNATCRTTLTGFKWLTNVGMSEQTDDNRFLFAYEEALGYTVGSMVWDKDGLSALVAFAQLTAELASKGQTIWDRLDEIYREHGFHLNAQVSIALKPETPNIGAYLRNNPPLSIAGKKVLVTDDISSGLRWFEDGHTESIALPASDVLIYQLEGGARVIVRPSGTEPKIKCYYEVVEAMTPTDSLTSVQARAQKVMDGFISAHQLSLPK
>NC_009831.1|WP_150104398.1|1803410_1803737_-|QacE-family-quaternary-ammonium-compound-efflux-SMR-transporter
MNSYLYLAIAIISEVIATTLLPITMGFTRILPSLACVIGYGSAFYFLSLATAHIPTAVAYAIWCGAGIVLIALIGALQGNMPNLDTIFGMVLIIIGVSLINMNTPSLH
>NC_009831.1|WP_012141862.1|1802494_1803343_-|RluA-family-pseudouridine-synthase
MSKNQIESHIKVTSLASDAAALLALESGLSKQLIKQAMNKGAVWLTRGKHTQRLRRAKRALKIGDELHLYYNQEVLEHEVADAELIADEGQYSLWYKPYGMLCQGSKWGDHTTINRYAETHLAPDRPAFIIHRLDRAATGLVLIGHSKKTTAALAKLFELRLLDKYYQVIVEGHFSNHGVDELVTIDSEVDGKPARSHAKQLKYDPEQNRSLVQVKIESGRKHQIRIHMASIGYPVVGDRQHGIADESEVNLQLTSCYLKFPCPITGEEKEFELPQRLRPEL
>NC_009831.1|WP_012141861.1|1801988_1802438_+|GFA-family-protein
MQNPIDDRKLVRTASCNCGQLSLTTMGEPKRVSVCHCTACQKRTGSAFGVQVRFPVESVEFVGRSKSYRRIGDSGSSICFHFCPDCGGTLWFILDGAATDVVIPMGNFADEQAFLEEHSSLKLPSPKIAIYEERAQPWVILEGIEERYS
>NC_009831.1|WP_012141860.1|1800733_1801831_+|NAD-dependent-epimerase/dehydratase-family-protein
MSASNLSVSNRQMALEHYHIDEQLVLKKLSGQVKRAFVTGAGGFLGKAICQRLIAAGVEVTGFARGAYPELSAMGVNMIQGDISDNLAVIDAMKGCELVFHVASKAGVWGCKQSYFSPNVDGAANIINACKRLNIGYLVYTSTPSVTFAGADEAGIDETAPYADKYLNYYGESKAIAEQMVLDANGSKLKTVSLRPHLIWGPEDPHLVPRVIERARAGRLKLVGREDKLVDTIYVGNAAYAHILAALNLTEEQSSAAGRAYFLSNDEPITMAAMLNKILTCADLPEVDKRVPANLAYAVGVILETIYGLLGKTEEPLMTRFVARQLSTCHYFDISAAKRDLGYSPLVSIDQGMVKLREYLEANPV
>NC_009831.1|WP_012141871.1|1813252_1814254_-|DmsE-family-decaheme-c-type-cytochrome
MKITNKFKTLSMAVLPALMVSAVLSLGFASTATASKWDAKMTPDEVEATLDKKFAEGKYSPKGADSCLMCHRKSEKVMDIFKGVHGSIDSSKSPMAGLQCESCHGPMGKHNKGGKEPMIAFGPDSTLSAEKQNSVCMSCHQDDKRMAWNGGHHDNAEVACASCHSVHTDKDPVLSKNTEMEVCTSCHTKQKADMNKRSSHPMKWAQMVCSDCHNPHGTLADSDLVKPSVNETCYSCHAEKRGPKLWEHAPVTEDCVTCHNPHGSVNEGMLKTRAPQLCQQCHASDGHASRANFGNTGQGSSVGDNAFTGGNSCLNCHSKIHGSNHPSGKLFQR
>NC_009831.1|WP_012141872.1|1814333_1816316_-|OmcA/MtrC-family-decaheme-c-type-cytochrome
MMNVKNNKFALLLAASAVSMALTGCGGSDGDDGNNGNPGGPVAEYINTLNLDVTKVTYVDGMPSIEVFATNEEDLPVVGLKDFEVKKVAQLLPQGSTGAGDNAQWQVIGSQKTFIDNQDGSYTFDIEVEGYDSALTQRYNVIAKASTLLDGVTTVPQAEIAEDFSGEGYEATYTKDIVSTASCNACHAEGEKIYHSYMTQETCATCHTKEYAEERGKPEIEWNHLVHNVHNSAKGYKADRDTGEFTKDAVTAQHIVQNDCTNCHVAPEDGTEGLTEWGNWTRVPTMETCTSCHVNIDFEAGKGHSQQADNSNCVACHNASWTEELHTEDALQKKAVIDQIGMNATLTAVQDDKSANLTISFTDSAGNVLDVTNLLPKIKRVESITNVGPNFPIMGYNPSPGNGEHKVALDLVQSGELANNAEIADGNLVINTGTLPFGAAGTDTDTAFSFIGLEVCSDGAELINCAEGVATTSMKAELAHGTLSGEAPSTRHIDSVNFATCESCHGETFELHKGYHAGFIMTEQLGREVNGQMTVGVDGCVACHTPDGTYMSGGNKGAFEMKLHVVHGEQGIIKDCAQCHNDFNLDAFKVKGALATPAGYTTPIAATCTSCHTSDSTKLHAVGQGAIIDGSYEAANDAAQLETCFFCHNPAISDHTQVKM
>NC_009831.1|WP_012141873.1|1816750_1818967_-|OmcA/MtrC-family-decaheme-c-type-cytochrome
MMKKFNSFNAKRSAAAKAVLSAGILSFALAGCGSDGKDGEDGKDGVVGVNIDAAKSVNAIFTNATVEAGVVTVDFKLQNDNGVAVLGLTKDHDLRFGIAQLSHVTEMMGETEVDRGYQWQAYINAEKTPNPDWVPEGESHINPSNQFQANVEKAGDCETCFVDNEDGSYTYTYQQNIGSVVEPVEVTYNAEETQRATMELELSSFAANANYDWQPSTGTTEGIQTRDVVSIETCYTCHQPESLELHGGRRINIENCASCHTGTSGDPESGNSVDFTFMIHAIHKGQERMTSTAEGMVPAPYKVIGYGGGVHDYGKVMFPQKPAANCAACHVEGENAPANADLFKANLSNTACVGCHTEKPSQMHSSTDCMSCHIEEGYARSGVEAHGDATKAYDVSKNYSATFSNIKPEGQGLSFDVQLLDDAGAPIAKEFIYKLGYSNPYIVVSWDVDADYPAYKTGSKYSERRISLYDASQATYDEANKTFSVVSANIALPADINGKSFELLPVVKTCFKKGGYGRPLVEPMSCYDDDGVTIAGNAKAAYIQDEPMRFIWNNGQSEEPAVARRSIVDDAKCHNCHGAEFYHDSNGVNCQACHTSDKAVKESERNSGKFDKPTSFAYKAHHAEGHYLKYAGVGSKTVVKTDCKTCHTDNGFELGRSPERVWNYPNLETLDSTGIFVSSDAGTCLSCHQKYLDDAAKSHIVTNGGILDGTSTEDVRTRAAEACQTCHTPEKVIALHGH
>NC_009831.1|WP_012141874.1|1819447_1821616_-|OmcA/MtrC-family-decaheme-c-type-cytochrome
MERKIMDIKRKSSTLNLIALTCSALLFGCGSDGKDGEDGKDGVVGVNIDSTATLSANISTASVTDGLITINFDLTNANGVAVLGLTKDHDLRFGIAQLTRVSETMGDTEVDRGFNWQAYINAEKTPNPDWIPEGESHINPSNQYQANVEKAADCDECFLDNGDGSYAYTYQVNIAEVTEPLTVTYSADSTQRATLELELPQVTANAFLDWQPSSESSEGIQTRDVVSIETCYTCHQVESLALHGGRRIAIENCASCHTSTSGDPESGNSVEFTYMIHAIHKGNERMTSTADGMVPAPYKIIGYGGGIHDYGKVMFPQGPAADCSSCHVEGEGAPADADLFKADLSNTACVGCHTEKPSQNHSSTNCIGCHNSTDTYPGTGSAEKRHFDVMKAYSDARAMSVEFSNIGLTADGKIKFDLQIIDAAGTAIAGEFINQGTRVVVAWDSDKDYPAYNDASYSNRRIKLSEGTYDANSKTFTITGNNFDMPNDADGKTFELWSAVEVCFNKGGYGVAEVMMTECSDNTRSIEVKEEAYHFVWSGTGMDADAQAATRRSIIDTTKCQGCHNQEVFHYDNGVNCQTCHTSDKTTKSDDSYPGGKKPTSFAYKAHAAEGHYLKYAGVESGTVLKTDCMTCHTDDGIKLGRVSDRVWRFGHKTSGEDIWVSSDVGTCLSCHQKYLSDAGASHIVTNGGILDGTSEEDVQTRASEACSTCHTPEQLMSLHAH
>NC_009831.1|WP_041421594.1|1821681_1823619_-|OmcA/MtrC-family-decaheme-c-type-cytochrome
MNKSTKSNTVSLYRLIPLTLTLLLAACGSGDDGAPGNPGEPGGPPASDISTLMVEVTGVTTDAGIATVNYRVSNQDDEPVVGISTGTYIAAQLLPQGYTNAGNSSQWQYFVSESCSSGCTGELIDHKNGSYSYTFSAAFDGLNDVSYQPGSTQRVMIKIGGDTLPDGSPLPTTNQHFDWSDSGEPAYTRDLIAIETCNSCHNDLAFHGPSGFEKYNEVETCVTCHNADRVSNPDNIFPQMIHTKHLVGFPGELANCQTCHASDETLTENMNWARVPGMEACGSCHTNIDFPAGEGHPAQTDNSNCVACHNSDWTANVHNDGGDDEALGQFNANIVSASLTGNTVTFNITLTNPVTNTVYADSADKLDFIDDLRVYANWGTSFDYAPSAKSLKLQDSSPISGSNGIYTYAISGLTIPAGTESDRGVLAIQGKLCSSQGELGDCEEDAFSTVNLKSSHQFFSAAELTDTGRRVVVTNDTCGSCHGVQALNFHGARNDLQGQCQLCHNPNMMADATASNPSVSTADYKHLIHSLHSAQREGYEGLNYPGQIGNCAQCHASDDTGLLSAALPLNLGVKPLAIDNGTFTSATAAICSDCHFSDTAKNHMTQQGAVFMGSEADATAGTESCSTCHGEGAPADILKVHPINE
>NC_009831.1|WP_012141876.1|1823756_1825892_-|MtrB/PioB-family-decaheme-associated-outer-membrane-protein
MNKRILNPAPYTGLLPIKLSLVAMAIGSLLSPAYADGYGLSQANRAAVKLDKWQCKRCSVSTDTRGSIGAGIAYNDGTDNRFGNTSGTNEDGAVGHLEADILLKNKSGYQTRIEADKLGYDSGSAQVSTGAPGQYKVVLGYRGIANYDTSSALTPYLVDGDKMNLPDNWQTGATTGQMTELSGSAAPVALKTQRDRFTLGAGYTGSFYKAELDYRHEDRKGKRTFSGNLLTNSVMLAQPIDDSTDNLGAKIYFNGANWLAGVDAMLSHYNNDHDAINWQSAFTPTFGAAYRGQSATAADNRAYRIAANAQLGSNGHQVLMHTGFSRFSQDETFLPATINGPSPTLPQSSLDGQVDMIEMTLKYSGRITRELSIRASYDYKDRDNKTRVLNMPQVITDSYYAGTAINPEYDHTRQKASFAAKYRFSRNIYLDTGYRYDHNRYSDLDRETLQESGVYGRLNYRPSQAWSFGLKADIKDRSGSEYGVVTSTSSTSNPLMRKSYLADREHQEYRLQADYNGSGALSASANLHTSHDDYTDTNIGLTDVKTSGYYISAQYLIDDDLSLNAFFNQDWRDSEQAGSSNFGSANWYANLDERSTLVGAGMQYQNLIDSKLSLGLDYNYSDGQSDTEITQGFTSPYGDYFSTKHNINAFADYRFSEKMAIRIDWIFEQYEDADWSNQGITLDAIPNVLTFGSLSHDYSAHYLGLTLSYHL
>NC_009831.1|WP_041422047.1|1825907_1826870_-|DmsE-family-decaheme-c-type-cytochrome
MNMESARFKQKVPLFLLFALTTICFNILAAPWDDKDPAEVEAILDSKFVEGKYSSKGADSCLMCHRKSSDVMALFDGVHGNPDINGSPMADLQCEACHGPQGKHNRGGKEPMITFGADSPLPAQKQNSVCLSCHNDEQRMVWSGNHHDNADVSCSGCHLVHTGKDPISDRKREVEVCSSCHTQQKADIHKRSAHPLKWQQMVCSDCHNPHGSLSDSNLKQMSVNENCYSCHAEKRGPKLWEHSPVSDNCANCHNPHGSVNEGMLISKPPQLCQQCHASDGHASNAVFANSNNAFNAGQSCMNCHSQIHGSNHPSGKLLQR
>NC_009831.1|WP_012141878.1|1827300_1827555_+|ferrous-iron-transport-protein-A
MKLSDLNPGEHATISEVGQLSLPSVVKRKLLSMGITPNTSFLMIRKAPMGSGLELDIRGSKLCMRRDLADVIDVERVEVEKANA
>NC_009831.1|WP_012141879.1|1827547_1829842_+|Fe(2+)-transporter-permease-subunit-FeoB
MPKQFHCVTVGNPNAGKSTLFNALTGANQQVGNWSGVTVEKKTGLFTLNGADVYLTDLPGIYDLLPAGSTCDCSLDEQIAQQYLAEQQVDGIINLVDATNIERHLYLTVQLRELGIPMVVVLNKIDAAKKHGIEIDTENMARTLGCPVVSVCSRDEADIEKVKAQVVDLLEGKVSEAPLVLDYDPRIETGVNSLLSNDDNLSRGRALAMLGNGLGCGKCKNGQMLDEVNQCSESLSSQGKDIEIMVATTRFDFVQNVYTSSVNANGAETLSDKLDKVILHPVAGVPVFLFVMYLMFMFSINVGSSFIDFFDITAGAIFVDHLGALMSGMGSPTWLVTIIAGGIGQGIQTVATFIPVIAALFLALSVLEGSGYMARAAFVVDGLMRRIGLPGKAFVPMIVGFGCSVPAIMATRTLGSERERIVTGMMAPFMSCGARLPVYALFAAAFFPESGQNLVFMLYIIGVLAAVGTGLLLRSTLLPGSSSAVVMELPSYEKPKFKTVMNRTGKRTKSFIMGAGKTIVIVVTLLNFVNSIGIDGSFGHEDSSESVLSVASQKVTPLFAPMGVEQDNWPATVGIITGIFAKEAVVGTLNSLYSTPSDGEEELAPFIETLNEALATIPDNLLGIQVNDPLGLDVGDVSSVAVASEELEVDTSTFTALQAGFTGIAAAFAYLLFILLYTPCVAAMGALVGEFGGRWAAFAGTWTFGLAYGTATIFYQAATFSAHPLQSSLWIGFFVTALVVFYVWLKQKAKRSQTIIPGIKIITE
>NC_009831.1|WP_012141880.1|1830004_1831675_+|glutamine--tRNA-ligase
MSHVDSEVRPSNFIRNIIDEDLESGKHTSVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGLCNLRFDDTNPEKEDIDYVHSIQDDVKWLGFQWDGEIRYSSNYFDKLHQYAIELINKGLAYVCFLNSEETREYRGTLKEPGKNSPYRDTSVQENLELFEKMRKGEFKEGECALRAKIDMASSFMCMRDPVIYRIRFAHHHQSGDKWCIYPMYDFTHCISDAIENISHSLCTLEFQDNRRLYDWVLDQLDDFKAPNRTRQYEFSRLNLEYTLMSKRKLNDLVVRDVVHGWDDPRMPTIAGLRRRGYTSASIREFCKRIGVTKQENMIEVGMLDACIREELNEHAPRAMAVINPVKVIIENYPQDQIETINAPVHPSNEEMGKRELAFGRELFIDAADFREEANKKYKRLVQGKEVRLRNAYVIKAERCDKDAEGNITTIYCTYDDETLGKNPSDGRKVKGVIHWVEASTAKPAEFRLYDRLFTDANPAAAETIDEVLNPDSLVVTHGLVEAGLITAEAEKAYQFEREGYFCADNKDSTPESLVFNLTVALRDSSQ

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Crispr_ID: NC_009831_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009831_3

2570852-2570927

Orphan

Consensus_repeat	Method
TTTGTGTCTGGAACACTTATGTCTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_009831_3

>merge|NC_009831|3|2570852-2570927|CRISPRCasFinder
TTTGTGTCTGGAACACTTATGTCTAATTACCATGGATGGATTTAAATAGACTTTGTGTCTGGAACACTTATGTCTA

>NC_009831|3|3|2570852-2570927|CRISPRCasFinder
TTTGTGTCTGGAACACTTATGTCTA	ATTACCATGGATGGATTTAAATAGAC
TTTGTGTCTGGAACACTTATGTCTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_009831.1\|WP_012142463.1\|2566621_2566822_-\|CPXCG-motif-containing-cysteine-rich-protein	unknown	unknown	gnl\|CDD\|379524
NC_009831.1\|WP_012142458.1\|2558972_2560190_+\|2-methylaconitate-cis-trans-isomerase-PrpF	unknown	unknown	gnl\|CDD\|131387
NC_009831.1\|WP_012142471.1\|2574151_2576665_+\|DNA-translocase-FtsK-4TM-domain-containing-protein	unknown	unknown	gnl\|CDD\|236669
NC_009831.1\|WP_012142460.1\|2562299_2562800_+\|VF530-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|226976
NC_009831.1\|WP_012142461.1\|2564556_2565933_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|234981
NC_009831.1\|WP_012142474.1\|2578739_2579114_+\|fluoride-efflux-transporter-CrcB	unknown	unknown	gnl\|CDD\|172685
NC_009831.1\|WP_041421643.1\|2565965_2566580_+\|riboflavin-synthase	unknown	unknown	gnl\|CDD\|183846
NC_009831.1\|WP_012142464.1\|2567678_2569607_+\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234752
NC_009831.1\|WP_041421646.1\|2581299_2581581_-\|sulfurtransferase-complex-subunit-TusB	unknown	unknown	gnl\|CDD\|377218
NC_009831.1\|WP_012142469.1\|2572168_2573284_-\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NC_009831.1\|WP_012142475.1\|2579132_2580419_+\|serine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235461
NC_009831.1\|WP_012142466.1\|2570236_2570431_+\|50S-ribosomal-protein-L35	unknown	unknown	gnl\|CDD\|234676
NC_009831.1\|WP_012142470.1\|2573464_2573968_+\|leucine-responsive-transcriptional-regulator-Lrp	unknown	unknown	gnl\|CDD\|183009
NC_009831.1\|WP_012142476.1\|2580853_2581189_-\|TusE/DsrC/DsvC-family-sulfur-relay-protein	unknown	unknown	gnl\|CDD\|213798
NC_009831.1\|WP_012142467.1\|2570449_2570809_+\|50S-ribosomal-protein-L20	unknown	unknown	gnl\|CDD\|179959
NC_009831.1\|WP_041421642.1\|2560367_2561978_-\|ABC-F-family-ATPase	unknown	unknown	gnl\|CDD\|237894
NC_009831.1\|WP_012142468.1\|2571082_2572033_-\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|182343
NC_009831.1\|WP_012142473.1\|2577415_2578747_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NC_009831.1\|WP_012142472.1\|2576779_2577406_+\|outer-membrane-lipoprotein-chaperone-LolA	unknown	unknown	gnl\|CDD\|178807
NC_009831.1\|WP_083758938.1\|2569610_2570153_+\|translation-initiation-factor-IF-3	unknown	unknown	gnl\|CDD\|234582

Protein	Function_ID	Function_description	E-value
NC_009831.1\|WP_012142463.1\|2566621_2566822_-\|CPXCG-motif-containing-cysteine-rich-protein	gnl\|CDD\|379524	pfam14255, Cys_rich_CPXG, Cysteine-rich CPXCG. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There are 5 conserved cysteines which occur in a CPXCG motif and a DCXXCCXP motif.	9.02385e-20
NC_009831.1\|WP_012142458.1\|2558972_2560190_+\|2-methylaconitate-cis-trans-isomerase-PrpF	gnl\|CDD\|131387	TIGR02334, conserved_hypothetical_protein, probable AcnD-accessory protein PrpF. The 2-methylcitrate cycle is one of at least five degradation pathways for propionate via propionyl-CoA. Degradation of propionate toward pyruvate consumes oxaloacetate and releases succinate. Oxidation of succinate back into oxaloacetate by the TCA cycle makes the 2-methylcitrate pathway a cycle. This family consists of PrpF, an incompletely characterized protein that appears to be an essential accessory protein for the Fe/S-dependent 2-methylisocitrate dehydratase AcnD (TIGR02333). This protein is related to but distinct from FldA (part of pfam04303), a putative fluorene degradation protein of Sphingomonas sp. LB126. [Energy metabolism, Fermentation].	0
NC_009831.1\|WP_012142471.1\|2574151_2576665_+\|DNA-translocase-FtsK-4TM-domain-containing-protein	gnl\|CDD\|236669	PRK10263, PRK10263, DNA translocase FtsK; Provisional.	0
NC_009831.1\|WP_012142460.1\|2562299_2562800_+\|VF530-family-DNA-binding-protein	gnl\|CDD\|226976	COG4628, COG4628, Uncharacterized conserved protein [Function unknown].	1.81145e-41
NC_009831.1\|WP_012142461.1\|2564556_2565933_-\|MATE-family-efflux-transporter	gnl\|CDD\|234981	PRK01766, PRK01766, multidrug efflux protein; Reviewed.	0
NC_009831.1\|WP_012142474.1\|2578739_2579114_+\|fluoride-efflux-transporter-CrcB	gnl\|CDD\|172685	PRK14197, PRK14197, fluoride efflux transporter CrcB.	8.86633e-63
NC_009831.1\|WP_041421643.1\|2565965_2566580_+\|riboflavin-synthase	gnl\|CDD\|183846	PRK13020, PRK13020, riboflavin synthase subunit alpha; Provisional.	1.7049e-132
NC_009831.1\|WP_012142464.1\|2567678_2569607_+\|threonine--tRNA-ligase	gnl\|CDD\|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0
NC_009831.1\|WP_041421646.1\|2581299_2581581_-\|sulfurtransferase-complex-subunit-TusB	gnl\|CDD\|377218	pfam04077, DsrH, DsrH like protein. DsrH is involved in oxidation of intracellular sulphur in the phototrophic sulphur bacterium Chromatium vinosum D.	2.19314e-20
NC_009831.1\|WP_012142469.1\|2572168_2573284_-\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NC_009831.1\|WP_012142475.1\|2579132_2580419_+\|serine--tRNA-ligase	gnl\|CDD\|235461	PRK05431, PRK05431, seryl-tRNA synthetase; Provisional.	0
NC_009831.1\|WP_012142466.1\|2570236_2570431_+\|50S-ribosomal-protein-L35	gnl\|CDD\|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	1.90253e-19
NC_009831.1\|WP_012142470.1\|2573464_2573968_+\|leucine-responsive-transcriptional-regulator-Lrp	gnl\|CDD\|183009	PRK11169, PRK11169, leucine-responsive transcriptional regulator Lrp.	9.12896e-116
NC_009831.1\|WP_012142476.1\|2580853_2581189_-\|TusE/DsrC/DsvC-family-sulfur-relay-protein	gnl\|CDD\|213798	TIGR03342, dsrC_tusE_dsvC, sulfur relay protein, TusE/DsrC/DsvC family. Members of this protein family may be described as TusE, a partner to TusBCD in a sulfur relay system for 2-thiouridine biosynthesis, a tRNA base modification process. Other members are DsrC, a functionally similar protein in species where the sulfur relay system exists primarily for sulfur metabolism rather than tRNA base modification. Some members of this family are known explicitly as the gamma subunit of sulfite reductases.	6.99827e-65
NC_009831.1\|WP_012142467.1\|2570449_2570809_+\|50S-ribosomal-protein-L20	gnl\|CDD\|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	1.28327e-68
NC_009831.1\|WP_041421642.1\|2560367_2561978_-\|ABC-F-family-ATPase	gnl\|CDD\|237894	PRK15064, PRK15064, ABC transporter ATP-binding protein; Provisional.	0
NC_009831.1\|WP_012142468.1\|2571082_2572033_-\|thioredoxin-disulfide-reductase	gnl\|CDD\|182343	PRK10262, PRK10262, thioredoxin reductase; Provisional.	0
NC_009831.1\|WP_012142473.1\|2577415_2578747_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NC_009831.1\|WP_012142472.1\|2576779_2577406_+\|outer-membrane-lipoprotein-chaperone-LolA	gnl\|CDD\|178807	PRK00031, lolA, outer membrane lipoprotein chaperone LolA.	1.43244e-53
NC_009831.1\|WP_083758938.1\|2569610_2570153_+\|translation-initiation-factor-IF-3	gnl\|CDD\|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	4.38599e-94

>NC_009831.1|WP_012142467.1|2570449_2570809_+|50S-ribosomal-protein-L20
MPRVKRGVTARARHKKVLKLAKGYYGARSRTYRVAKQAVTKAGQYAYRDRRQKKRQFRQLWIARINAASRQNGLSYSRFINGLKKASIEIDRKILADIAVFDKVVFTTLVEKAKEALAK
>NC_009831.1|WP_012142466.1|2570236_2570431_+|50S-ribosomal-protein-L35
MPKMKTDKGVAKRFKKTANGFKRKQAHLRHILTKKSTKRKRHLRAKCQVAKSDVPAIARQLPYA
>NC_009831.1|WP_083758938.1|2569610_2570153_+|translation-initiation-factor-IF-3
MKIKKTAGRQAAPNRINELITGVSEVRLNGLEGEALGVLTIRDAQELADEAGVDLVEISPNAEPPVCRIMDYGKFLFDKAKAQKEQKKKQKQIQVKEVKFRPGTDENDYQVKLRNLNRFLDDGDKAKVTLRFRGREMAHQSLGMNLLNRIKDDLAEIAVVESFPKMEGRQAVMVLAPKKK
>NC_009831.1|WP_012142464.1|2567678_2569607_+|threonine--tRNA-ligase
MPVITLPDGSKREFANPVSTLDVAADIGPGLAKACIAGRVNGELKDACDIIDTDSELSIITAKDEEGVEILRHSCAHLLGHAFKQLWPEAKMAIGPVIDNGFYYDIDLDHKLTQEDIDALQKRMTQLAKTNYKVEKRVGSWQVARDTFEARGETYKMEVLDENISKDDQPALYHHEEYVDMCRGPHVPNMKFCQNFKLMSVAGAYWRGNSDNKMLQRVYGTAWADKKALKVHLNRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSLFLELEKFIRQKLGQYTYQEVKGPLMMDRVLWERSGHWDKYADAMFTTNSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHVFCTEDQVQQEVSACIKMVYDTYETFGFKDIVVKLSTRPEKRIGDDDMWDRSEEALKQALTANGIAYEILPGEGAFYGPKIEFTLHDCLDRAWQCGTVQLDYALPGRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGKFPTWLAPMQVVVMNITDKQSDYVDEVVNIFKESGIRASKDLRNEKIGFKIREHTLRRVPYLLVVGDQEMDNKEVAVRTRDGVDLGKMRIEDFASKINEQISLRSLNLLED
>NC_009831.1|WP_012142463.1|2566621_2566822_-|CPXCG-motif-containing-cysteine-rich-protein
MRYATQTISCPHCGHHQHIDVDGTSGDQDYYDDCRICCNPIHLRIHIDEARHKIELFIDSGDEQIY
>NC_009831.1|WP_041421643.1|2565965_2566580_+|riboflavin-synthase
MFTGIVQATCEVVAINKKDGLNTLEIAMEPELREGLITGASVANNGVCLTVTRIANDRVFFDVMEETLSVTNLSNLTLGSKVNIERSLTFGSEIGGHILSGHVHTQARILEVSNTNSHFDIKLGVDPKWMNYILYKGFVGVNGCSLTVGEVTDSSFMLHLIPETLKLTNLDDSKVGGCLNIEIDSQTQAIVDTVERVLAKRAGS
>NC_009831.1|WP_012142461.1|2564556_2565933_-|MATE-family-efflux-transporter
MNQFGFQAKRLVQLALPVLIAQVTQTMMGFIDTVMAGRVSAVDMAAVAVGTSLWLPALLFVQGLLMAFTPVFAHQHGANNQKAIQPLAHQAGYIAIIGSIGVIVFLTFAQNIFTMMELEPELARLSIGYLNGFAWGVPAFVLYQVLRGCSEGISYTLPTMVIGFVGLAVNIPANYIFIYGHFGIPAMGGAGCGIATALVFWAMFIAMIIYMQLHKKFAELAPFKSFHKPDWKTMWDMTKHGFPIAMALFFEVSLFAVIALLLAPLGANVVAGHQIALNFSSIVFMLPLSIGIAVSIRVGYYLGQDKAHISKLITKVGLSLSFTLAIITAIITVLFRTEIAYLYNDNPEVVALAGSLMFLAALYQLSDSVQVVAAGALRGYKDTRSALYITLVSYWAIGMVLGYILARTDLIVPHMGAHGFWIGLIAGLTSAAILFAWRLRHIQKTGDLKQVIMDTGHK
>NC_009831.1|WP_012142460.1|2562299_2562800_+|VF530-family-DNA-binding-protein
MIEQQQNNPLHGLSLETMLTELVDFYDWKILDAALRLACFKTNPNMPACLKFLKKTEWARERVEAFYLYRFKRMPKGSAAQFELKPRERGFEDGIVPRKPQELTVELIADMRAKATADYEAMKQNKGSRPRYGSDKPRAQDSYAQNRSSSHNKPAPSQDPKNPWGK
>NC_009831.1|WP_041421642.1|2560367_2561978_-|ABC-F-family-ATPase
MISTANITMQFGPEPLFENISAKFGNGNRYGLIGANGCGKSTFMKILSGELAPTSGNVSITPGQKVGTLSQDQFAFEEFSVIDAVIQGDAKLWEVKQERERIYSLPEMSEEDGMKVGELESEFAEMDGYSAESRAGEILLEAGIEEEFHFGLMSQVAPGWKLRVLLAQALFSNPDILLLDEPTNNLDIHTINWLAGQLNKRKCTMIIISHDRHFLNTVCTHMADIDYGELRIYPGNYEYFMEAAALIQEQLLAGNAKKSAEMNELQDFVNRFGANASKAKQASSRAKKLEKISLDEVKSSSRMTPSLRFDDGKKLHRQALVLENLGHGFDDEILFEGGELILEAGAKLAVIGENGVGKSTFLRCLVNELQNNQGVVKWSENASIGYCPQDSSKDFDNDLNLFDWMSLWRTPKHNDLMVRGMLGRLLFTEDDANKKVKNCSGGEKNRLLFGKLMMMDINVLIMDEPTNHMDMEAIEALNNALKTYQGTLIFVSHDREFVSSLATRIIDVKDKRLVNFQGTFNEYMASQQEMEARKVS
>NC_009831.1|WP_012142458.1|2558972_2560190_+|2-methylaconitate-cis-trans-isomerase-PrpF
MTSKKVHPPQKHLPQIKVPATYMRGGTSKGVFFNLTELPKSAQIAGSARDALLLRVIGSPDPYGKQTDGMGGATSSTSKTVIVAKSAKADHDVDYLFGQVAIDKPFVDWSGNCGNLSAAVGSFAISSGLVDPSRIPENGIVVVRIWQKNISKTIIAHVPITNGEVQETGDFELDGVTFPAAEVEVEFMDPADGEGAMFPTGNLVDDLVLPTDVIASGVLNATMINAGIPTVFVNAKDLGYTGAELQEAINGDVKALAMFESIRAHGAVKMGLIKHIDEAAGRQHTPKVAIVAEPVDYTSSSGKLINKADIDLNVRALSMGKLHHAMMGTAAVAIGTAAAIPGTLVSLAAGNIERESVHFGHPSGTLRVGAQASLVNSEWRVNKAVMSRSARVLMEGWVLVPADVL
>NC_009831.1|WP_012142468.1|2571082_2572033_-|thioredoxin-disulfide-reductase
MSQARHCELLILGSGPAGYTAAVYAARANLKPVLVTGLQQGGQLTTTTEVENWPGDAEDLTGPALMERMQKHAEKFETEILFDHINEVDLKVRPFKLKGDNGDFTCDALIISTGASAMYLGLESEEAFKGKGVSACATCDGFFYRNQKVAVIGGGNTAVEEALYLSNIASEVHLIHRRDAFRSEKILTKRLMDKVENGNIILHLDNTLDEVVGDQMGVTGLKMKSTKDGSITDLEVMGVFVAIGHKPNTQMFEGQLEMNNGYIKVQSGLDGNATQASIEGVFAAGDVMDQHYRQAITSAGTGCMAALDAERYLDSK
>NC_009831.1|WP_012142469.1|2572168_2573284_-|alanine-dehydrogenase
MIIGVPKEIKNHEYRVGMVPSSVRELTNKGHTVFIEANAGTGIGFTDQDYIDVGASILATAAEVFATAEMIVKVKEPQAVERAMLREDQLLFTYLHLAPDLPQTEDLVKSGSVCIAYETVTDDRGALPLLAPMSEVAGRMSIQAGAMALEKNMGGRGMLLGGVPGVEPAKVVIIGGGMVGTNAAQMAVGLGAEVVILDRNIDTLRRLNVQFDNKVKAIYSTADAIEKHVLEADLVIGGVLVPGAAAPKLVTKDHIKRMKPGSAIVDVAIDQGGCIETSHATTHQDPTYIVDDVVHYCVANMPGAVARTSTFALNNATLPYIIKLAELGYRKALLQDKHLLNGLNVMHGKITCSEVAEALNMEFVDPAILLN
>NC_009831.1|WP_012142470.1|2573464_2573968_+|leucine-responsive-transcriptional-regulator-Lrp
MVNNKKSPIKDLDRIDRNILNELQTDGRISNVELSKRVGLSPTPCLERVKRLEKQGYINGYTALVNPHFLGASLLVFVEITLNRDSSEVFDKFNRAVQLLDDIQECHLVSGDFDYLLKTRVSDMSAYRRLLGETLLRLPSVSDTRTYVVMEEVKQTSKVAINVTAES
>NC_009831.1|WP_012142471.1|2574151_2576665_+|DNA-translocase-FtsK-4TM-domain-containing-protein
MSKGNSIKTLSGVQRLLEGGLIICCMLATYVLLALSSFYSSDPGWSQSHFEGEIQNVTGAVGAWTADVLFYFFGYTAYLIPIIMALTGWLLFKRTHKLLEIDYFSVGLRLIGFLLIVFSLAALASMNANDIYEFSAGGVAGDVIRDAMLPYFNKLGTTLLLLCFVGAGFTLLTGISWLTIVDLTGFSAIWVFNSLRSLPERFKRDSGETEDTQGFMSVFDKFKEKRNQSEDDFEDEELDSERLDTHLNQFEELNHGEQLNTNSRIEPQLESEEDAIDDEVHLAPSATAPETELDEIDFDSQTSVGAVSLAKPKVVESAKIVDGIVVLPGQDLEQAKKPITPLPSISLLDVPNRKANPISREELEQVGALVEVKLADFNIVAKVVGVFPGPVVTRFELELAPGVKASKVTNLSKDLARSLLAESVRVVEVIPGKAYVGIELPNKFRETVFMRDVLDSKTFAESKSHLSMVLGQDIAGEPVVVDLGKMPHLLVAGTTGSGKSVGVNVMITSLLYKSGPDDVRFIMIDPKMLELSVYEGIPHLLCEVVTDMKEAANSLRWCVGEMERRYKLMSALGVRNLKGYNAKIKEAKESGQPITDPLWKSSDSMEPEAPELDKLPSIVVVVDEFADMMMIVGKKVEELIARIAQKARAAGIHLILATQRPSVDVITGLIKANIPTRMAFQVSSRIDSRTILDQQGAETLLGMGDMLYLPPGTSIPIRVHGAFIDDHEVHAVVADWHSRGKPQYIDEILQGSTEGEQVLLPGEASDAEEESDALYDEAVAFVTETRRGSISSVQRKFKIGYNRAARIIEQMEAQGVVSSQGHNGNREVLAPPPPKAF
>NC_009831.1|WP_012142472.1|2576779_2577406_+|outer-membrane-lipoprotein-chaperone-LolA
MRKTLSILAISLPLLVSGYAQASESGVLKAKLAEISTLKANFTQTVTDVNKKEIQKGSGVFALAYPNQFYWHLTEPDESLIVADGRDVWIYNPFAEEVSVMDLNQAINASPIALLVHRDEETWSKYTVTNEEGCFSIAPKSVDAGVESVDVCFDGNTLTQMVLQDQQGNVSQFMLSDQTAISDDELSMFKFTVPDDVDIDDQRLNTVN
>NC_009831.1|WP_012142473.1|2577415_2578747_+|replication-associated-recombination-protein-A
MSSFSFDFAPDFRPLAARMRPETISQYIGQTHLLGEGKPLRKALEAGRAHSMMFWGPPGTGKTTLAELVANYANAHVERISAVTSGVKEIRTAIEHAKNVAESRGQRTLLFVDEVHRFNKSQQDAFLPFIEDGTVIFVGATTENPSFEINNALLSRARVYLIKKLTNDEIVHIVRQALTDEERGLGKRKLLIPDNVALKLANVSEGDARKALNLIELMSDMLADGGSFSEEMIIEVAGQQLAGFDKNGDQFYDLISAVHKSIRGSAPDAALYWFCRMLEGGCDPLYIARRLLAIASEDIGNADPVAMTVALNAWECFHRVGPSEGERAIAQAIVYLASAPKSNSVYTAFKAARQLARETGQEAVPEHLRNAPTQLMQDLGYGEGYRYAHDEPNSYASGECYFPEGLAESRFYYPTEHGFEKRIKAKLEHLAQLDRDSEIKRYE
>NC_009831.1|WP_012142474.1|2578739_2579114_+|fluoride-efflux-transporter-CrcB
MNNILFVALGGSIGAVFRYLLSIFMLQLFGSAFPFGTLLVNVIGSFLMGTIYALGQVSQVSPEIKALVGVGLLGALTTFSTFSNETLLLIQSGAWIKAFFNIALNLCLCIFMVYLGQQLVFSRI
>NC_009831.1|WP_012142475.1|2579132_2580419_+|serine--tRNA-ligase
MLDPKFLRTELEATAERLATRGFILDVERLSKLEEKRKSLQMATEELQASRNAISKSIGQAKAKGEDVAPIMAQVGDLGSQLDTKKQELAELLETLNAIAMSVPNLPDESVPAGADESENVEVRRWGTPKEFNFEVKDHVELGETLGGLDFKAAVKITGTRFIIMKGQIARMNRALAQFMLDLHTTEHGYTEAYVPLLVNEESLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPLTNIARDTIIDEADLPVKLTAHTPCFRSEAGSYGRDTRGLIRQHQFDKVELVQLVKPEDSMAALDSLTGHAETVLQKLELPYRTVVLCTGDMGFGSSKTFDIEVWLPAQNTYREISSCSNMQDFQARRMQARYKAKSAKKPALLHTLNGSGLAVGRTLVAVIENYQNEDGSITVPEVLRPYMGGLEKIG
>NC_009831.1|WP_012142476.1|2580853_2581189_-|TusE/DsrC/DsvC-family-sulfur-relay-protein
MNSFEYKGEQIETDTQGYLKQVSQWNEEIAELIAAQEEITLTPAHWEVIHFVRDFYLEYKTSPAIRILVKAIGQKLGADKGNSKYLYTLFPTGPAKQATKVAGLPKPAKCI
>NC_009831.1|WP_041421646.1|2581299_2581581_-|sulfurtransferase-complex-subunit-TusB
MNLHHIQTSAKQDNALACCIKYMDKQDSILLSGNGVNSLLLSQWRERLANIRVMLLIDDVEARGLSQRFEDYTLIDYDTFVKESLTHDKVITW

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Crispr_ID: NC_009831_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009831_4

2770224-2770324

Orphan

Consensus_repeat	Method
TGCCTATCTTCACATCTAACCTTCGCGGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_009831_4

>merge|NC_009831|4|2770224-2770324|CRISPRCasFinder
TGCCTATCTTCACATCTAACCTTCGCGGCTGAAGCACGCTCCTACAGCAAGACATATCATTTCGGATGCATTGCCTATCTTCACATCGAACCTTCGCGGCT

>NC_009831|4|4|2770224-2770324|CRISPRCasFinder
TGCCTATCTTCACATCTAACCTTCGCGGCT	GAAGCACGCTCCTACAGCAAGACATATCATTTCGGATGCAT
TGCCTATCTTCACATCGAACCTTCGCGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_009831.1\|WP_012142630.1\|2769240_2769984_-\|DTW-domain-containing-protein	unknown	unknown	gnl\|CDD\|225690
NC_009831.1\|WP_012142638.1\|2779073_2779778_-\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|234695
NC_009831.1\|WP_012142634.1\|2774407_2774581_+\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012142639.1\|2779882_2781043_-\|lipopolysaccharide-assembly-protein-LapB	unknown	unknown	gnl\|CDD\|236983
NC_009831.1\|WP_012142640.1\|2781044_2781335_-\|DUF1049-domain-containing-protein	unknown	unknown	gnl\|CDD\|226294
NC_009831.1\|WP_012142626.1\|2761712_2762312_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|226932
NC_009831.1\|WP_012142635.1\|2774782_2776240_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl\|CDD\|182972
NC_009831.1\|WP_083758943.1\|2758441_2759635_+\|FAD:protein-FMN-transferase	unknown	unknown	gnl\|CDD\|224394
NC_009831.1\|WP_049772112.1\|2759974_2761720_+\|PhnD/SsuA/transferrin-family-substrate-binding-protein	unknown	unknown	gnl\|CDD\|226654
NC_009831.1\|WP_012142637.1\|2778420_2778963_-\|DUF2058-domain-containing-protein	unknown	unknown	gnl\|CDD\|378260
NC_009831.1\|WP_012142632.1\|2772390_2773704_-\|CDP-diacylglycerol--serine-O-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|236510
NC_009831.1\|WP_012142633.1\|2773715_2774048_-\|DUF1904-domain-containing-protein	unknown	unknown	gnl\|CDD\|370190
NC_009831.1\|WP_049772159.1\|2762916_2764395_-\|efflux-transporter-outer-membrane-subunit	unknown	unknown	gnl\|CDD\|273830
NC_009831.1\|WP_012142631.1\|2770647_2771874_+\|multidrug-efflux-MFS-transporter-EmrD	unknown	unknown	gnl\|CDD\|183259
NC_009831.1\|WP_012142628.1\|2764421_2767589_-\|multidrug-efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|273335
NC_009831.1\|WP_012142623.1\|2756823_2758170_-\|FMN-binding-protein	unknown	unknown	gnl\|CDD\|377242
NC_009831.1\|WP_150104418.1\|2755702_2756746_-\|porin	unknown	unknown	gnl\|CDD\|238208
NC_009831.1\|WP_041421668.1\|2762422_2762668_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012142636.1\|2776423_2778181_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173842
NC_009831.1\|WP_041422136.1\|2767588_2768788_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776

Protein	Function_ID	Function_description	E-value
NC_009831.1\|WP_012142630.1\|2769240_2769984_-\|DTW-domain-containing-protein	gnl\|CDD\|225690	COG3148, COG3148, Uncharacterized conserved protein [Function unknown].	2.01055e-83
NC_009831.1\|WP_012142638.1\|2779073_2779778_-\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|234695	PRK00230, PRK00230, orotidine-5'-phosphate decarboxylase.	2.02373e-142
NC_009831.1\|WP_012142639.1\|2779882_2781043_-\|lipopolysaccharide-assembly-protein-LapB	gnl\|CDD\|236983	PRK11788, PRK11788, tetratricopeptide repeat protein; Provisional.	0
NC_009831.1\|WP_012142640.1\|2781044_2781335_-\|DUF1049-domain-containing-protein	gnl\|CDD\|226294	COG3771, COG3771, Predicted membrane protein [Function unknown].	2.28159e-15
NC_009831.1\|WP_012142626.1\|2761712_2762312_+\|response-regulator-transcription-factor	gnl\|CDD\|226932	COG4566, TtrR, Response regulator [Signal transduction mechanisms].	2.63602e-62
NC_009831.1\|WP_012142635.1\|2774782_2776240_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl\|CDD\|182972	PRK11113, PRK11113, D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional.	1.0633e-131
NC_009831.1\|WP_083758943.1\|2758441_2759635_+\|FAD:protein-FMN-transferase	gnl\|CDD\|224394	COG1477, ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism].	1.31776e-55
NC_009831.1\|WP_049772112.1\|2759974_2761720_+\|PhnD/SsuA/transferrin-family-substrate-binding-protein	gnl\|CDD\|226654	COG4191, COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms].	3.51894e-39
NC_009831.1\|WP_012142628.1\|2764421_2767589_-\|multidrug-efflux-RND-transporter-permease-subunit	gnl\|CDD\|273335	TIGR00915, Probable_aminoglycoside_efflux_pump, The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family. Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate].	0
NC_009831.1\|WP_012142633.1\|2773715_2774048_-\|DUF1904-domain-containing-protein	gnl\|CDD\|370190	pfam08921, DUF1904, Domain of unknown function (DUF1904). This domain is found in a set of hypothetical bacterial proteins.	7.13882e-44
NC_009831.1\|WP_049772159.1\|2762916_2764395_-\|efflux-transporter-outer-membrane-subunit	gnl\|CDD\|273830	TIGR01845, Outer_membrane_protein_OprM, efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family. Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins].	1.04382e-87
NC_009831.1\|WP_012142631.1\|2770647_2771874_+\|multidrug-efflux-MFS-transporter-EmrD	gnl\|CDD\|183259	PRK11652, emrD, multidrug transporter EmrD.	0
NC_009831.1\|WP_012142632.1\|2772390_2773704_-\|CDP-diacylglycerol--serine-O-phosphatidyltransferase	gnl\|CDD\|236510	PRK09428, pssA, CDP-diacylglycerol--serine O-phosphatidyltransferase.	0
NC_009831.1\|WP_012142623.1\|2756823_2758170_-\|FMN-binding-protein	gnl\|CDD\|377242	pfam04205, FMN_bind, FMN-binding domain. This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins.	6.39771e-13
NC_009831.1\|WP_150104418.1\|2755702_2756746_-\|porin	gnl\|CDD\|238208	cd00342, gram_neg_porins, Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers are stabilized by hytrophillic clamping of Loop L2. Loop 3 bends into the pore, creating an elliptical constriction of about 7 x 11A, large enough to allow passage of a glucose molecule without steric hindrance. Removal of the C-terminal residue (usuallly F) destabilizes the trimer and removal of the 16th beta-sheet abolishes trimerization. Unlike typical membrane proteins, porins lack long hydrophobic stretches. Short turns are found at the smooth, periplasmic end, longer irregular loops are found at the rough, extracellular end. C-terminal residue forms salt bridge with N-terminus.	1.25486e-33
NC_009831.1\|WP_012142637.1\|2778420_2778963_-\|DUF2058-domain-containing-protein	gnl\|CDD\|378260	pfam09831, DUF2058, Uncharacterized protein conserved in bacteria (DUF2058). This domain, found in various prokaryotic proteins, has no known function.	1.72363e-63
NC_009831.1\|WP_012142636.1\|2776423_2778181_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	2.25911e-152
NC_009831.1\|WP_041422136.1\|2767588_2768788_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	6.82842e-66

>NC_009831.1|WP_012142630.1|2769240_2769984_-|DTW-domain-containing-protein
MSFHQHAVHRLYRYRKAISTKPYGARGKNLVRCEQCLLAEVYCTCESRTQLESNNAFLLIMYDDEVLKPSNSGRLIADLIPDTHAYIWSRTQANRKMLALIQSPEYQPFVIFPGEYAYDNQPIVDKVIPSSIGEGKRPLFIMLDGSWREAIKMFRKSPYLHSLPLLSFTPETAAKYGLRKGSRDFQLGTAEVAALALGASGEQGNAESLNAWFELFIESSIFSRSRKSTSDLTPLMELTQAFKASLK
>NC_009831.1|WP_041422136.1|2767588_2768788_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MGFAILLGSLAGISGCEEVAPTIIPKAVVVEQVSTATVPLYGNYIGITKASLDVEVRARVNGFVEDKSFIEGSGVKEGSVLYRIDDRPYVAVVNRLKANMESQQSVLDKAQRDVERLKPLYEQDAASQLDFDNALSLLSQAKSSLAASKAQLEEAQLELSYTSIRSPISGLVSRSEVDIGALVGSSGQSLLTRVKQVDPIYVTFNMSALDYLNARRRMTSYSEKKEAESEGKAVEGFVTITLPDNSEYRYLGDVRFTDPSVNPETGTFQVRAELPNPDKELLPGQYTNVRIKLNEVNNAIVIPQKATQVEQGGVYVMVVLPDNKVERRFIVIDHQGPMGVVVQSGLKAGELVIIEGMHRVRHGQIAEPLTAEQYHKKEDSKEKQQALKQQELEQIQEQE
>NC_009831.1|WP_012142628.1|2764421_2767589_-|multidrug-efflux-RND-transporter-permease-subunit
MAQYFVNRPVFASVISIVIVLLGVIAMFQLPIDQYPYITPPQVKVSASYPGATSTTAAESVATPLEQELNGVPNMIYMSSKSTNSGSANVTITFDVGTNPDLAAVDVQNSTQQATGSLPIDVQTEGVSVSKEASVELLKLALTSSDERYDEIYLSNYATINIQSALKRIPGVGRVRNTGSRSYSMRVWLKPDMMAGYGLTTSDVIGAIKAQNRESPAGSIGSQPNTDSLSMTLPITAAGRMSSVPQFNEIIVRANTDGSLIRLRDIASIELGSSAYTLQSQLNGANATILQVYLLPGANALEVTKRVKQEMAALGEKFPQGMEWQVFFDASIFIQNSIDEVVKTLIEALVLVILVVYLFLQNWRATLIPAIAVPVSLIGTLAAMLAFGFTINTVSLLALVLAIGIVVDDAIVVVENVERLMHENGLSPTEATKVAMKELSGALVATSLVLAAVFVPVSFLSGITGIMYREFAVAITVAVLISTVVALTLSPALCALLLRPGDQATSGFFKWLNDKLDMSTSKYVALVTLTNKHAKRSYLAFAVMVGGVYVIMSGLPSSFMPDEDQGRFFIDMSLPNGATVNRSQAVLKKAEAKVLNHPAVAYSFTLAGENRRSGSNQANGMFEIILKPWSQRADDNATVQQVMKDIKVSLQDILEAEFSVYLPSAVPGLGNGSGVEMELQDTSGTNFKGLMETADELVEALKLQPEIATAGLSLQSAIPQLHLSVDEAKAMAIGVNISDIYSTIKTFTDSSTVNDFNLFGRVYRVKVQAEDKYRQFPEQIKDYYVRSSSGAMVPIGVLAEYDYSVGPAAVTHYNLFTSASINASPAQGYASGDVIRAINRVATPMLPNEFRYEWTGITYQEVQSANQTGIAVTLAMVFVFLFLCALYESWTIPIAVLLIAPIAMLGAALGTFVSGMESNLFFQVAFISLIGMAAKNSILIVEFANQLHKQGKSRLEAALEAANMRFRPILMTSMAFILGVLPLVLSVGPGAVSRQSISIPILCGMIFATTIGIVLVPLFFVTTAGWFKSKTESKSEMQSAENESITPTGEQGGAV
>NC_009831.1|WP_049772159.1|2762916_2764395_-|efflux-transporter-outer-membrane-subunit
MFKRSLSKPGQNRIACIALMGCTTLLAGCAMGPDYQQPELDLPGQYHNELQQGEGDNIGKTQWRDFYLDPQLQPLINHALAQNLDLEAMRSRLIAARQRITVTDAALYPKVGIDAYGERSLDSGLTNTEPSSEDEFNLSGVVSWELDIWGANRRRSEAEYANFLSAQESLNLATISLISDVASRYYEWLDIEQRYQISTNTVALRKKELDLARLRKENGVISGLEVRQAEVEFQSAKVTLPDLDFERGEKANQLRILLGEFGYPLQLQTEAELRVEDALFPAQFNVGVPSEMLSQRPDVKAAEQALIAMNAKVGVAKTAFFPKFTISGSFGRESDELSNLLDSEGVTWSLLGGITAPIFNAGSISAQYEIAKEESKQALLAYRNTVLRAYFEVNDAMNSFRRSELAINAQQELVAASSEYNRLAGLRYRNGVASSLDLMDAQRKLFSAQLALSQIKRDRLLSMITLYRALGGGILSLQDAPPVMAADIIEGE
>NC_009831.1|WP_041421668.1|2762422_2762668_-|hypothetical-protein
MTKRPIHKFLLLTVYSVATYLSVSMLAGVDNSAYLYSFKQETNQQRVQQITFNRYQVGHVCKERGWEFCKKWSRYSRTRLA
>NC_009831.1|WP_012142626.1|2761712_2762312_+|response-regulator-transcription-factor
MCDIYLVDDDQDVLNSLSWMLDGLGLKTQGFLNAASFLSAVDITRPGIAILDIQMPGMDGIALLHHIKVAASPMSVIMLTGHGTITMAVQAIQQGAIDFLEKPVDGDKLSLLLARAKEISLQSFDELRLQTEIEHRVASLTPREHEVMLKVLEGKLNKVIAAELNIAQRTIELHRQKVMQKMQVSNAAELAYLMAKSEE
>NC_009831.1|WP_049772112.1|2759974_2761720_+|PhnD/SsuA/transferrin-family-substrate-binding-protein
MKRILLLITSLLSCFASAGGNEPVRIGVLSFASPHTVYQRWAPTFDRVAEDTGHTFSVLPLTPGELQESVANDKLDFIIGNALTTVTFKKDYGVSNLLSLVPNYHSDPDHAIGSALITRSSINIEDIEQLSTMSVVSSDPNAFGGFQILAGELASLSINPFKDFKKLTFVGFPQDKLLNLVLDKKADVAILPSCVLESAIEKGLVPESALKVVLQKEVPNYECAVSSSLYPSYAFSKLGHTSHVLATQVVKSLLTITNKDKEAISGRYQYWSAPVNDREVFRLLRTLNRWPFVTNWEFLLKGAVPWVIGALILLLLGYLHHLRVKRLVVLRTRALSSEMEQHQHTQKELFEQQKQFYKAQRVLLTGEMASGIAHELNQPLAGIRYLTQGCLYRLTPEQGELNSALNKAIEQVDRAQSTIKRFRQFCQQPSVYEKCDLKNLIEETLNLMAPEFKRMNISPKLSLERVTTIADISLIQQVLVNLIRNSLDAMESEALPELGIRLVKEDNQALIVIEDNGIGLSEEALSRLFFPFETSKEKGLGLGMVICKRIIEEHGGQIHAVNLIKGLKISVSLPIKEQQDV
>NC_009831.1|WP_083758943.1|2758441_2759635_+|FAD:protein-FMN-transferase
MNRLPIINRRFGPSLLSTLLVLGVSVSSTVMAKPNSELAIQETFKPYQCEGNGIISHTGGVSTLNTLKYFGTSITIDVYNSKPEQAGQALCHALNVVQEYHYLASNYSTYPHVENIKSINNSPASIHKIDPKLTALIAAGLDWYDKSDGYFNIALSPVINLWRKHRSECKGKIKDNGLCTKPGMDKLQNAAEYINIEDISLNQADNTIRLKTGMSIDLGGIAKGWMAEKVYEQLKSEGLTSFMINAGGNIRHLGLHTEGREFVTAIEDPLCKKFDYQLPECREFEGQYHEVIHGTDLTIVSSGNYLRYYRVKDKEYHHLIDPKTLQPKPEGISTSVVLDGLQIFADVISTTLFLMPLEQALEFADRSDYLEAVWYLDNEGNKVSSANFDKYRFKLSD
>NC_009831.1|WP_012142623.1|2756823_2758170_-|FMN-binding-protein
MIKNNRFKRSLVCSAVTIASLGLAGCATTPIEGKYVDGTHEVSGKGKKSQITLTVNVKEGKITDVTTKSHKETESLFLNAERLLAKIVSNNGHEGIDAVSGATFSSNGILKAINKLPRADGSTPEYVAVGSKEVSGNDDFKLKWSIQPQLGMIIGDYYYQEARFRQGHMGSMAIVVDSDNAKDVIFAEFNESGRPNYYTRLFQDVPKRTSEYNFSMGKKKGTAWVQSALTMEKLMVEQDKLTFDLNPDYDPKLRNKLKQPNRLKYSGIDVVAGASNSIQQSMVPLTAKIHAQINGEGSTLKFYQNAEKQLDKNGKWTGITTVLRLIVDTETKQITKSYFDEVFADEKNEIKDASLKKHYRQSKYASINYVEPARIGFNVMFDALNVHLQQGGSLFDINDLPATGDSGSYAATGFTKRSSSWDIYLKQADILYSQMRADNVIKTHNKPN
>NC_009831.1|WP_150104418.1|2755702_2756746_-|porin
MMKTFTLSLLATSMLISPQILADDLLKFYGRIDYSVTNSDSGSATHNGKSGTVLENNWSRLGVKGSSEIMDDTEIFYQIEVGVNGASQDKGKNPFSSRPTFIGIKHASVGQLAAGRIDPVFKMAKGTADAMDMYSMKHDRLFAGDKRWGDSLEYKSVKWNKLQLGASYIMEDNYYGEDDLRRDNGNYQLALTYGDKHFRSSNLYLAAAYTDGVEDIKGYRGVVQYKYGNLMLGSIYQASELVNPYKTNWEQRDGSGFIVSAKYQIDKLLLKAQYGQDDSGTGRIAAKVYDKYGESVTQTPEVSQWAVGAEYRVSKSTRLHTEIGQFDVEQFDDFDDTIVSVGVRYDF
>NC_009831.1|WP_012142631.1|2770647_2771874_+|multidrug-efflux-MFS-transporter-EmrD
MNGPLMKSNPSQNNPGFSSLIFLIVMMVACGQMAQTIFVPALPAIADSFTVTAGQLQAIMACYLLSYGLLQFVYGPASDRLGRKPLLIFGLSLFVIGALLASVATSYSELIAATLLQGMGTASAGALCRSIPRDHYFGEPLVSLNSYISMAVIFSPLLAPFAGGMMTHYFGWQSVYSLLAGFGALVLLLVIFRLKESLPADKRKPESIMSSYRFVLAHRKFKSYLLCLVATFSGIAAFEAVAGVLYGQVLALSPFWVSIYFVAPIPGYLAGAYYAAKLKDNNKSTYRSVALLGSGALFLLIPGLSDLVIGWSLLVGSVLFFTGAGILFPVLTSAALEPFPRHAGVAGALLGGLQNFGAGVAALLMSLVPMHGQLSIGGLCALMVMLVILALNYARSGTDLDKSDVAVL
>NC_009831.1|WP_012142632.1|2772390_2773704_-|CDP-diacylglycerol--serine-O-phosphatidyltransferase
MLNKLGGIPVQPDAIRWLLTPKGLKAELLERIASAEHSIYISALYLEDDEAGREILTALMSAKQRTPSMDIKVLVDFHRARRGLIGHKGDSGNYQMYRKVMAEAEHPIDILGVPVKSREFMGVLHLKGFIVDDTVIYSGASINNIYLHQQEKYRFDRYHVIDSAELARSMRQMIQTYLVEDIAVCSLTQDKECELLPEKNDVRSLKNRLSKAHYEFTKVNQGNRITPLVGLGRKKNRLNKLVVDMVAQSKESLFICTPYFNPPYVLARAMAKHLKDGKRIDIVVGDKTANDFYIPPEEEFSTIGALPYMYEQSLRKFAKRQQWAIESGQLSIHLWKDGINSYHLKGISADDKCHLITGSNLNPRAWALDLENGLLLQDESGAWKEKFQVEQAHILQHTERLYHYSQLETLNNYPAPVRKIMTRIRRLKADFLLRRIL
>NC_009831.1|WP_012142633.1|2773715_2774048_-|DUF1904-domain-containing-protein
MPHIRMRGLPEAAVAELSKTLLERLADICEVNSQGFTLDWIPSVGYRNGSADQSFTQVEMLWFPKDPETHHLVEKVIREAVQKAYPESLHIVVMFRQLEPETYYRNGQHF
>NC_009831.1|WP_012142634.1|2774407_2774581_+|hypothetical-protein
MNLKILITLAIALVLAWAVFHFKAQLGLFILPIFIALVSFVTLRLYRLMEKDAPEDE
>NC_009831.1|WP_012142635.1|2774782_2776240_+|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MKKLTSALLLYWLSTSTACADEYFSNILSLIKPPHSHTSVIATDLVNDSVIYEENADILLLPASTQKLLTAVAATAALGNQFNYKTEIYSHFPIRNGKIMGDVFIKFSGDPTLTSLELRELFKQLTDQGLLQIEGDLYLVGEKHEELQAPGWVWDDLGICFAAPVSSFIINKNCVHGQLKPTLASSASQIQFPSYLPVIIDNSAIFDKNSTLEFCNLSLQRLTNNHFNLTGCHSGNRPLKLAIAITEPALFARDTVAQIAKSSQIKVTGKILLKDTLPQHRSLIASHQSKALPEMLNTMLVKSDNLIADSLLKQIGHKQYNRPGTFTNGSKAMVQILTEEGVDLTHARIVDGSGLSRYNLLSARQLSQVLRLIYTDPRFMSLMESLPVAGISGTLKYKPSFTSAPLRKYVWAKTGSMQGVDNLAGFIKKPKTDDMLFVILENGQSPIEKEQQLAPFSALFLQTLLDHTAAPTELNATTAKSVIAN
>NC_009831.1|WP_012142636.1|2776423_2778181_-|acyl-CoA-dehydrogenase
MNPYQAPLAEMKFMLDKVFDAPNTWASLPAIAENVDMDTAVAIMDEADKISRELIHPINRSGDEQGVRHEDDKVITPDGFKAVYDQYAEGGWVGLCGDPELGGMGMPKMLGVLVDEMSYSACNSFTLYGSLTAGAALCINAHGSDELKEKYLPMLYSGEWAGAMDMTEPQAGSDLRNIRTKAVPNDDGSYNITGSKIFITGGDHDLTENVIHLVLAKLPDSNGISLFLVPKIKVDDSGNLGESNGVTVGSIEHKMGLKASATCVMNYDDAQGYLIGRPNRGLVCMFTMMNYERLAIGIQGLGTSQAAYQMASDYAKERVQGVAAGGSPTGATCDPILVHGDVRRMLLNIRTLTEAGRALSILTGKQLDIAKYGEGEDKAKAARYVGLLTPVAKAFLSDRGLDAAIMAQQVFGGHGYIRETGIEQLVRDTRIAQIYEGTNGIQAIDFLGRKVTGDNLAALTEFVTECNEKLSQMTHVDDAHKEKVASLFNQLLAVADTVNDNKISSPALINTCAVDFLDAFGHILYGYFWLLMTDTAAVHEDEKFTAQKRHLSDFYINKVLPKAEYHLAQVSAGDVCVMNIPEETF
>NC_009831.1|WP_012142637.1|2778420_2778963_-|DUF2058-domain-containing-protein
MANPFQEQLLKAGLVSKQKVQKAKTQKKRDRKAKVDDGSAALKQEIAAQKKAQAEKDKALNEKRFEEASEKGLVRGLVTEFKRLAIKLPQHAELKFNYTFNNKIFSLYVDEKLQSQLLNGQLGIVRHEETSYLVPHKLAERVNMLVPEWCGYLWVKDDKTQVVEEDDPYADYVIPDDLMW
>NC_009831.1|WP_012142638.1|2779073_2779778_-|orotidine-5'-phosphate-decarboxylase
MNNKPIVVALDFDDKNAALQLIDRLDPQMCRLKVGKEMFTLFGPELVKDIHSRDFDLFLDLKFHDIPNTVAKAVTAAAELGVWMTNIHATGGLAMMEAAKKALVPYGKDAPLLIAVTVLTSMSDEDLKLIGIDVPAFEHVQRLARLTQQAGLDGVVCSAHEAQLLKSSLGESFKLVTPGIRPAGADKGDQHRVMTPPQAIEAGSDYLVIGRPITKAADPLAALTAIHQSLSIPG
>NC_009831.1|WP_012142639.1|2779882_2781043_-|lipopolysaccharide-assembly-protein-LapB
MLEILFLLLPIAAGYGWYMGRRSVRHKQSSDRKKLSRDYFTGLNFLLSNESDKAVDLFISMLDVDDDTIDTHLSLGSLFRKRGEVDRSIRIHQNLIARPSLATEQRDIAMMELGKDYLAAGFYDRAEEIFQNLVKQDDHSEAAETHLIDIYQVTKEWQKAINIIKSLKRKRQLVLKHNTAHFYCELANEEADSGGQLKLLQAAIKQDPQCGRAILTLAQKYLDQGELIKCKDMLYKLLEADVELIPDALATCRQAYHESNDSTGYCDFLRQALQQGAGASVAITLAQHLIEQGETQAAEKLVLDGLYRHPTMKSFQHLMQMQMLQAEDGQAKESLTMLEKLVQQQIKFRPGYRCSECGFPSHSLYWHCPSCKSWGSIKRIRGLDGE
>NC_009831.1|WP_012142640.1|2781044_2781335_-|DUF1049-domain-containing-protein
MKSFIITVLVALFFFLALIFGARNEQVVTISYFVAQGEFRLPIVLAVVFLAGFLISWIFAMYHIAKLKLALRTANKKNLNLENKITDPTLLQEVDA

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Crispr_ID: NC_009831_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009831_5

3434165-3434265

Unclear

Consensus_repeat	Method
CCTACTTCAATACATAATTGCGTCTCAACAGCTTC	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NC_009831_5

>merge|NC_009831|5|3434165-3434265|CRISPRCasFinder
CCTACTTCAATACATAATTGCGTCTCAACAGCTTCGCGGCTAAAGCCGCTCCTACATAGGGTGAAACCTACTTCAATACATAATTGCGTCTCAACAGCTTC

>NC_009831|5|5|3434165-3434265|CRISPRCasFinder
CCTACTTCAATACATAATTGCGTCTCAACAGCTTC	GCGGCTAAAGCCGCTCCTACATAGGGTGAAA
CCTACTTCAATACATAATTGCGTCTCAACAGCTTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_009831.1\|WP_150104432.1\|3444641_3445637_-\|ferrochelatase	unknown	unknown	gnl\|CDD\|234585
NC_009831.1\|WP_012143177.1\|3433282_3434056_+\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012143182.1\|3443160_3444465_-\|inosine/guanosine-kinase	unknown	unknown	gnl\|CDD\|185033
NC_009831.1\|WP_012143172.1\|3427827_3428103_-\|acylphosphatase	unknown	unknown	gnl\|CDD\|184676
NC_009831.1\|WP_012143181.1\|3441701_3443012_+\|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl\|CDD\|366058
NC_009831.1\|WP_041421718.1\|3429253_3430267_-\|beta-N-acetylhexosaminidase	unknown	unknown	gnl\|CDD\|235417
NC_009831.1\|WP_012143171.1\|3426749_3427697_+\|peptidoglycan-binding-protein-CsiV	unknown	unknown	gnl\|CDD\|371320
NC_009831.1\|WP_012143185.1\|3446670_3447516_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|225660
NC_009831.1\|WP_012143175.1\|3430587_3431964_+\|L-serine-ammonia-lyase	unknown	unknown	gnl\|CDD\|273233
NC_009831.1\|WP_012143179.1\|3437552_3438890_+\|N-succinylarginine-dihydrolase	unknown	unknown	gnl\|CDD\|237332
NC_009831.1\|WP_041422204.1\|3421202_3422435_-\|lipoprotein-releasing-ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|274034
NC_009831.1\|WP_012143187.1\|3449752_3450352_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NC_009831.1\|WP_012143186.1\|3447639_3449556_-\|molecular-chaperone-HtpG	unknown	unknown	gnl\|CDD\|235366
NC_009831.1\|WP_012143173.1\|3428621_3429161_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|179896
NC_009831.1\|WP_012143180.1\|3438968_3441485_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376772
NC_009831.1\|WP_012143184.1\|3445827_3446472_-\|adenylate-kinase	unknown	unknown	gnl\|CDD\|234711
NC_009831.1\|WP_012143170.1\|3423274_3426748_+\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182649
NC_009831.1\|WP_012143169.1\|3422532_3423138_+\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012143178.1\|3434353_3437023_-\|type-I-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|236048
NC_009831.1\|WP_012143176.1\|3432084_3433059_-\|HTH-type-transcriptional-regulator-CysB	unknown	unknown	gnl\|CDD\|183678

Protein	Function_ID	Function_description	E-value
NC_009831.1\|WP_150104432.1\|3444641_3445637_-\|ferrochelatase	gnl\|CDD\|234585	PRK00035, hemH, ferrochelatase; Reviewed.	8.78385e-163
NC_009831.1\|WP_041421718.1\|3429253_3430267_-\|beta-N-acetylhexosaminidase	gnl\|CDD\|235417	PRK05337, PRK05337, beta-hexosaminidase; Provisional.	0
NC_009831.1\|WP_012143182.1\|3443160_3444465_-\|inosine/guanosine-kinase	gnl\|CDD\|185033	PRK15074, PRK15074, inosine/guanosine kinase; Provisional.	0
NC_009831.1\|WP_012143172.1\|3427827_3428103_-\|acylphosphatase	gnl\|CDD\|184676	PRK14429, PRK14429, acylphosphatase; Provisional.	5.88032e-61
NC_009831.1\|WP_012143179.1\|3437552_3438890_+\|N-succinylarginine-dihydrolase	gnl\|CDD\|237332	PRK13281, PRK13281, N-succinylarginine dihydrolase.	0
NC_009831.1\|WP_012143171.1\|3426749_3427697_+\|peptidoglycan-binding-protein-CsiV	gnl\|CDD\|371320	pfam10972, CsiV, Peptidoglycan-binding protein, CsiV. CsiV, a small periplasmic protein (cell-shape integrity in Vibrio), is essential for growth of Vibrio cholerae in the presence of DAA, non-canonical amino-acids, the typical components of peptidoglycan side-chains in Vibrio cholerae. CsiV interacts with LpoA, the lipoprotein activator of penicillin-binding-protein1A that is necessary for mediating the assembly of peptidoglycan. CsiV acts through LpoA to promote peptidoglycan biogenesis in V. cholerae and other vibrio species as well as in the other genera where this protein is found.	8.03062e-55
NC_009831.1\|WP_012143185.1\|3446670_3447516_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|225660	COG3118, COG3118, Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones].	2.48525e-69
NC_009831.1\|WP_012143175.1\|3430587_3431964_+\|L-serine-ammonia-lyase	gnl\|CDD\|273233	TIGR00720, hypothetical_protein_NEICINOT_00681, L-serine dehydratase, iron-sulfur-dependent, single chain form. This enzyme is also called serine deaminase and L-serine dehydratase 1. L-serine ammonia-lyase converts serine into pyruvate in the gluconeogenesis pathway from serine. This enzyme is comprised of a single chain in Escherichia coli, Mycobacterium tuberculosis, and several other species, but has separate alpha and beta chains in Bacillus subtilis and related species. The beta and alpha chains are homologous to the N-terminal and C-terminal regions, respectively, but are rather deeply branched in a UPGMA tree. This enzyme requires iron and dithiothreitol for activation in vitro, and is a predicted 4Fe-4S protein. Escherichia coli Pseudomonas aeruginosa have two copies of this protein. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	0
NC_009831.1\|WP_041422204.1\|3421202_3422435_-\|lipoprotein-releasing-ABC-transporter-permease-subunit	gnl\|CDD\|274034	TIGR02212, releasing_system_transmembrane_protein_lolC., lipoprotein releasing system, transmembrane protein, LolC/E family. This model describes the LolC protein, and its paralog LolE found in some species. These proteins are homologous to permease proteins of ABC transporters. In some species, two paralogs occur, designated LolC and LolE. In others, a single form is found and tends to be designated LolC. [Protein fate, Protein and peptide secretion and trafficking].	2.03949e-157
NC_009831.1\|WP_012143187.1\|3449752_3450352_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	4.84483e-114
NC_009831.1\|WP_012143186.1\|3447639_3449556_-\|molecular-chaperone-HtpG	gnl\|CDD\|235366	PRK05218, PRK05218, heat shock protein 90; Provisional.	0
NC_009831.1\|WP_012143173.1\|3428621_3429161_-\|alpha/beta-hydrolase	gnl\|CDD\|179896	PRK04940, PRK04940, hypothetical protein; Provisional.	6.00451e-133
NC_009831.1\|WP_012143181.1\|3441701_3443012_+\|dicarboxylate/amino-acid:cation-symporter	gnl\|CDD\|366058	pfam00375, SDF, Sodium:dicarboxylate symporter family.	1.76556e-137
NC_009831.1\|WP_012143184.1\|3445827_3446472_-\|adenylate-kinase	gnl\|CDD\|234711	PRK00279, adk, adenylate kinase; Reviewed.	2.58327e-135
NC_009831.1\|WP_012143170.1\|3423274_3426748_+\|transcription-repair-coupling-factor	gnl\|CDD\|182649	PRK10689, PRK10689, transcription-repair coupling factor; Provisional.	0
NC_009831.1\|WP_012143180.1\|3438968_3441485_-\|hypothetical-protein	gnl\|CDD\|376772	pfam02369, Big_1, Bacterial Ig-like domain (group 1). This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial surface proteins such as intimins and invasins involved in pathogenicity.	5.08948e-06
NC_009831.1\|WP_012143178.1\|3434353_3437023_-\|type-I-DNA-topoisomerase	gnl\|CDD\|236048	PRK07561, PRK07561, DNA topoisomerase I subunit omega; Validated.	0
NC_009831.1\|WP_012143176.1\|3432084_3433059_-\|HTH-type-transcriptional-regulator-CysB	gnl\|CDD\|183678	PRK12681, cysB, HTH-type transcriptional regulator CysB.	0

>NC_009831.1|WP_012143177.1|3433282_3434056_+|hypothetical-protein
MIFTLVLILIGALLLLVIGINVIQQQKERAEAERRTELARQRAIIDETEEVLSHTGMFPCSSQIVLVLYKRVQDALALAVQNAASQAGDYQRRGVDIKTQIDTLQSSPKTSPAIEGFRLPDNDKQILTLVQVLKKLKAILRAEHNKGKVEPAVFSEEEGRIDSLQLRINVDSMLSRSRAACFMKQYGSAKQMVTKALSTLHAIKAQTPNDPFIARKVDEAKAMLDEIMGAQKEASPVIKQEKDEEDIDVLFQPKKKW
>NC_009831.1|WP_012143176.1|3432084_3433059_-|HTH-type-transcriptional-regulator-CysB
MKLQQLRYIAEVVNHNLNVSATAENLYTSQPGISKQVRMLEDELGIQIFGRSGKHLTHVTPAGEQVISIANNILGKVESIKKVAEEYTKPDQGELNIATTDTQARYALPNIIRGFIDRYPKVNLHMHQGTPSQISELAARGDADFAIATEGMHLYSDLIMLPCYHWNRSIVVTRDHPLASRSNISIEDLGRFPLVTYVFGFDRESEIEKSFNRAGLEPRVVFSATSADVLKTYVRLGLGVGVIASMAIDPNMDRDLVAIDASHLFAHSTTKIGFRKGNFLRTYMYEFIEHFAPHLTKEVVEKAVGLRDPQSIENMFADIELPVR
>NC_009831.1|WP_012143175.1|3430587_3431964_+|L-serine-ammonia-lyase
MISVFDMFKIGIGPSSSHTVGPMKAGNIFINDLDRKGLLESTDELRSELFGSLGQTGKGHGTGKAVILGLMGEAPDTVDTDIIDKVLKEVSESEQLQMANGTNVIFSRDAGVIYHRRKSLPAHANAMTLYAFSKGKCIYERTYYSVGGGFILDEDEIKAQDASPAAPIQSAPFDFNSASELLAACTDNGLSISSLMMANELSVAPENQIREQLWHIWQTMKNCVERGYQKEGILPGGLKLRRRAPAMYRRLKAEGKNNIDPLTALDWVDLFALSVNEQNAAGDRVVTAPTNGAAGIIPAVLCYYDTFVEEVDIDVCSRYLLTAAAIGILYKKNASISGAEVGCQGEVGVACSMAAGALTEIMGGTIEHVENAAEIGMEHNLGLTCDPVGGLVQVPCIERNAMGAVKAINASRMALRGDGNHKVSLDKVIKTMMDTGKDMRSKYKETAKGGLAVNIVEC
>NC_009831.1|WP_041421718.1|3429253_3430267_-|beta-N-acetylhexosaminidase
MSYLMLDLLSTQASEEELSQLQHPMVGGVILFSRNYSNRTQLIALIKQVRSVRPDILIAVDHEGGRVQRFRDGFTAIPAMGDILPIAGKDMVLAKSWAVELGYLMAIELLACDIDLSFAPVLDLNGISKVIGKRAFGSEPDVVIELAGSFIDGMEQAGMAAVGKHFPGHGSVEADSHFDQAVDNRTRQQIVESDMRPFKQLIDQEKLHGVMPAHVIYPNIDPNPAGFSGYWLKQVLRNELAFKGVIFSDDLGMEGAGVVGGYKARAQAALDAGCNMILLCNDAAGATEVLNELVWPETLPERPASLLKPRLDVVTKALEDDARWTRAKEIAGKFPIN
>NC_009831.1|WP_012143173.1|3428621_3429161_-|alpha/beta-hydrolase
MILYLHGFDATSPGNHEKMRQLQFIDKDVRLVSYSTLHPKHDMQHLLNEVSRQLQQSDDSDPIIIGVGLGAYWAERIGFLNGIRSVLINPNLNPQENMVGRIDRPEEYADIAGKCVSEFRGKNQGKALVILSRKDQVNDNQSVSEQLGGFYQICWDEEQPHKFPVLASHLPQINLFKQA
>NC_009831.1|WP_012143172.1|3427827_3428103_-|acylphosphatase
MKRVLINVNGKVQGVCFRRFALSKAQELGLTGYVSNIEDGSVNILAQGAFPSVDSLIDWCHIGSPQAQVTRVLVEEDEADEIYLDFSIVQS
>NC_009831.1|WP_012143171.1|3426749_3427697_+|peptidoglycan-binding-protein-CsiV
MLRQTLLILLGFLSFTELAYAQDERWFEVEVYLFERSNADPQEQAPQQVQLTKTNKAIDLISPLFSTNITGASIGLEGCSSRDWATNADECNQQLKSTQVNHLSQIPSNIFAVEPQYGVPGGPAVLLSDSQNQFQEIINKLSRERGNRSLLHMTWQQSMLPRHKAKAVRLFSGQDYASRYELSGQTVQTHQTESVIPQFDFFGETLSDDTPKPVWELDGTLNIYLNHYLYVETALNLRKEGIKTVGIMMDNTHLNETLESVTTPFLFAIPMTQNRRVRSDEIHYFDHPDMGMILQIRKMEQPIDRVTEAVSVDVN
>NC_009831.1|WP_012143170.1|3423274_3426748_+|transcription-repair-coupling-factor
MKPFSVLTPPAVKSATRAQTLFTLGGASQAITLANIVQKHDGLTLAVTNDTPTALLLETELTYLLKEKDIPVWIFPDRETLPYDNFSPHQDLVSQRLETLSRIPNAKQSLVIVPITTLMMRLPPKSFLAGNVLLLTKGDNYCLQDVKQQLVDTGYHMVEQVYEHGEFAVRGSIIDLFPMGSTQPYRIELFDDEVESIRYFDPETQRSSGTIDSVRLLPAKEFPTNDAAIEGFRQRYRRRFEVLVKEPESVYQMVSRKLLPAGIENYLPLFFDDTASLFDYLPDDAQLVNIGDLEQAVKTHLAEIEIRYENRRVDPLRPLLSPKELYLLTEQIFSEFKQHPRTLLKVGDAQESGHQAKLEVLPDVTANHKLKQPLSLLQEFSEGAGNILFSAESEGRREALFELLSKIDIKPKLFAHFDDFVLSNAKLGLIVSPLSKGCIVEKSRGAKFSIICETELFGHKISQKRRRDKQRQISSDALVKNLAELKVGQPIVHLDHGVARYMGLETLDTGGLIAEYLMLEYSGGDKLYVPVSSLHLISRYSVGPDEEANLNKLGNETWAKAKRKAVEKIRDVAAELLDVYARRQARPGDACKVIEEEYAQFANSFPFEETVDQETSINAVMTDMCSPIAMDRLVCGDVGFGKTEVAMRAAFVAVNDGKQVAILVPTTLLAQQHYENFKDRFADWPVKIEVMSRFKTAKEQKHVMEELANGKVDIVIGTHKLLQSDAKFENLGLLVIDEEHRFGVRQKEKIKALRANVDILTLTATPIPRTLNMAMSGMRDLSIIATPPAKRLSVKTFIREYDDTTVIEALQREILRGGQVYFLHNNVESIEKRASELSELLPEARVVTAHGQMRERELEKVMSDFYHQKFNVLVCTTIIETGIDVPSANTIIIERADKFGLAQLHQLRGRVGRSHHQAYAYLMTPHPKRMTKDSVKRLEAIGALEDLGAGFLLATQDLEIRGAGELLGDEQSGHISKIGFTLYMEMLEDAVKSLKEGKEPSLDQMLRHQCEIELRIPALLPDDFVHDVNIRLSLYKRIANCETEQALDELRVELIDRFGLLPDATKNLMELTLYKHQATALGIKKLEMHAKGGSLEFNDDHKVDPGFIIGLLQSQPQNYRMDGPSKLKFIIPAESYSDRLALVKLLLGQLSQHRLGE
>NC_009831.1|WP_012143169.1|3422532_3423138_+|hypothetical-protein
MFTDSTPYFSVMHDFTVYLTLWPEDSPLPSESELKFMLPTGLLLISDVKALEADCLIQLRHFDDEAKSIVDYLKLQSRKIDLVLQHVIEQEQHEGEQHHGVSFGGSGIKIIGNAELEVGNQYKITLHIKEELIALLCFVKVSSNQVVDASDDASNAAESARYITELEFTQILDSDVEQLVKASLSVQQKHLKYRKLAQKAP
>NC_009831.1|WP_041422204.1|3421202_3422435_-|lipoprotein-releasing-ABC-transporter-permease-subunit
MNFALSAHIGFRYWRARKANTFASFITFFAVSGILLGVAALIIVSSVMNGLEGQLKQRILGAVPQLTVHASQPLTDWEKQVQGLKNLPGVLGATPSISTQAMVQSQTNISAVQVYGIYPAYEQELLRTMKRSFNGSFDKLEPRQYRVILGAELARRLDVVAGDTVRLLSGEGVVYSPLGPVPSQRKFIVAGVFEMGSQVDANLAYVHYEDAQRLMRQKSGEIKHLRLYLVDPFNAVSLTSKVVEQFENQGIEVTTSDWRESYGHLFSAVKMEKNMMSLMLSLIIAVAAFNIVSALVMMVVDKTTDVAVLKTQGLSTLTVMGIFMIQGSLNAILGLISGLLVGIGLSLNLNSILNTLGISVLGAGQSLPVQIEWTQLGWIVVGTLIITFLATVYPALRAAGVQPASALRYE
>NC_009831.1|WP_012143178.1|3434353_3437023_-|type-I-DNA-topoisomerase
MGKSLVIVESPAKAKTINKYLGKDYIVKSSVGHIRDLPTSSSTEAKVATKTPAEVRKMAPEEKAIYKSIKAKQALVSRMGIDPDKGWKANYQTLPGKEKVVKELQKLAESADQIFLATDLDREGEAIAWHLQEVIGGDASRYQRVVFNEITKSAIQDAFSKPSTLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVATRLVVEKESEIKAFVPEEFWDIHAQLETLNNAALKMQVVKFQDKAFNPVTESQAQTATSALSQSSFVVAARDDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDGVREMIAKEFGDKYLPEAPIRYGSKGGAQEAHEAIRPSDVSVQAASMKDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGEYELKATGRTLRFDGWTRVQTVVKKKNEEDNTLPVVAQGDKLNLQELMPKQHFTKPPARYGEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSESLVGSFKELMSYDFTASMEQTLDDVAQGELKWKKVLDGFYKDLTKQIEQAELAPEEGGMRPNEMVLTDNIKCPTCDRPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTPGEEAVSENSEDAETDALRAKHRCDVCGTAMDSYLIDEKRKLHVCGNNPICGGYEVEQGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNDDCKNTRKLLKSGEAAPPKEDPIHLPELKCTKSDGYFVLRDGAAGIFMAASTFPKSRETRAPLVEELVKYRELLWPKYAYLADAPVTDDDGNKATVRFSRKTKEQYVATDVDGKASGWASKFIDGKWVSESKKKAKPKAKAKPKEKK
>NC_009831.1|WP_012143179.1|3437552_3438890_+|N-succinylarginine-dihydrolase
MKHFEANFDGLVGPTHNYAGLSFGNVASLNNAAATSNPRAAAKQGLKKAKALADMGMVQGMLAPQERPDLHTLRRIGFSGTDAEILNKAAKEAPALLRACCSASSMWTANAATVSPSADTHDGKLHFTPANLVDKLHRSIEPETTGNILAATFNNSRHFAHHQHLPEHSSFGDEGAANHTRLCKDYGNAGVELFVYGQEATNPAAPKPSKFPARQTLEASQAIARLHQLDDENTVFISQNPDVIDQGVFHNDVIAVGNQNVLFYHEQAFLDTKRKLDEIKRKFGDSELHFIEVPTSRVAIQDAVKSYLFNTQIITLPSGEMAIIAPTNCQENEAVHAYLNEVVTLGSPIKQVNYFDVKQSMQNGGGPACLRLRVAMNDMELAAVNQHTLMNDALFTRLNAWVDKHYRDRLSVDDLADPQVLIESRTALDELTQIMKLGSVYQFQK
>NC_009831.1|WP_012143180.1|3438968_3441485_-|hypothetical-protein
MKSAYQVLVAFICSFFIVACSGGGDIVDDGGGGTTPPATITVELAVNNTQVSVAEPATITATVKSSTGAAVSTLVSFTLNNDTYGTFAPGTGEVATNADGVATIQLNTAEINTGATITATISSGESASLNVTMVGDGGEAGGGAQVSLVLTDTSGNPIQTISTLSPGRLTATVTGINKSVIVTFDSPIGDLPIKSAVTDADGKATVDIYAGSSLGAGEVTASLSTNEVGKTIVVVGATNVVMGSGTPFEEGVAEVSTVNLSAGGTATISVLIQDDQGTAFTQPVDVNFSSTCATKNPAQAQISSPVSSSNGVATSTYLAQGCVGEDQIHVTADAGGISLSAVGIINVLQADVGSIIFVSAEPENIGILGTGGTESSTVKFQVLDKNSNPVSNQNVIFELNTNVGGVDISPAVATTNNEGIVQTVVTTGTVATSVRVTATVDDNSNPVISSQSKQLIISTGIPDQDSFSLSAEVLNAEGWDRDGTEVKVTARMADAFNNPVPDGTTVSFTTEGGAIEDACQTVNGACSVTWTSQLARPEGQSLFDEKGDQIRNPKAELACYVLKVNEGDSSICDIANDAQTRVYGNIYGQQYGGRATITATAIGEETFPDLNGNGRFDASEMSEFLTGKDVTGEGFDLNDAFNDYNEDTIFNPQPSGQLIGHAGGALEELVDFNSNGVFDLKDGLYNGVLCSLPAHVGCADGIADSKSLYVRRSLTMVMSGSSAVATKHADIIIEDKDGVHNPGRITIVGKGSASVYFTISDLHNQQMPAGSKVIFTATAGSVVSGSEYIWPSSNHNGGRDVKVTVKGEDEPNSGVLLVQVETPNGVVTEVVAVGITIE
>NC_009831.1|WP_012143181.1|3441701_3443012_+|dicarboxylate/amino-acid:cation-symporter
MALTQARKLGLTSKILIGMGAGILFGLLLRNLFPESTFIENYVTEGFLNVIGTIFVSGLKMIVVPLVFISLVCGTCSLSDPSKLGRLGGKTIAFYLFTTAIALSMAISVAILVHPGNASLVSDGLVFNAKEAPSLSQVLINIVPTNPLQAMSEGNMLQIILFAVIFGFAISHIGERGKRVAALFNDLNEVIMRVVTLIMQLAPYGVFALMAKLALTLGLETFGSVVQYFFVVLGVLLLHAFVVYPSLLKIIAGLNPFTFIRKMRDVQLFAFSTASSNATLPVTIETAEHRLGVDNKVASFTLPLGATINMDGTAIMQGVATVFIAQVYGIDLTITDYTMVVVTATLASIGTAGVPGVGLIMLAMVLNQVGLPVEGIALIIGVDRLLDMVRTAVNVTGDTVATVVIAKSEKEFNEVTFNDTQAGKAASSFNDQLNAK
>NC_009831.1|WP_012143182.1|3443160_3444465_-|inosine/guanosine-kinase
MKFPGQRKSKHYFPVKNRDPLLAQMTQQPQRFPTYITGIDQTLVDIEAKVGDELLERYALPKGNSTLIDDEKAHALYSELKTNKLVSDEFAGGTIGNTVHNYSILADDRSVLFGVMSNNIEVGSYAYRYLCNTSSKVDLNYLQPVNGPIGRCFTLISECGERTFAISKGSMDKLTPEYIDKDIVQGASALILTAYLMRASDGDQITDAALKAIEYAKEAGVPVVLTLGTRFLIEEDPSWWKSFIKDNVTILAMNEDEGEALTGFKDPLQASEAALELCDLVLTTAGPLGLYMAGYTEDSEKRETSHTLLPGMIPEFNRYEFSRPKLKSACDTPIKVYAHISPYMGGPEKIRNTNGAGDGALAALLHDLASNTFHKANVPGSSKHMRDGLCYSSFSQVCKYANRVAYEVLAQHSPRLSRGLPEREDSLEEAYWER
>NC_009831.1|WP_150104432.1|3444641_3445637_-|ferrochelatase
MSETPPAFGVLLVNLGTPDSPSASDVKRFLKQFLSDPRVVDLNPLIWKPILNGIILNTRPAKVAKLYQAIWSDEGSPLMVVSQRQREKVASLLQEQLGQAIPVELGMSYGNPSLASGLEKLKQQGVKRIVVLPLYPQYSCSTVAPVFDAIAAEFKGWRDIPETRFNKEYYQDPTYIEALASSVKSHWNEHGQADVLLMSFHGVPVRYVNEGDPYQAQCQATALLLAQALGLKDEQWKLCFQSQFGKEEWLTPYTDKLLESLPEKGVKSVDIMCPAFAADCLETLEEISIGGKESFIESGGESYRFIPCLNDNEPHIELLAKLVTEQAAQWV
>NC_009831.1|WP_012143184.1|3445827_3446472_-|adenylate-kinase
MRIMLLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGLVKERVAQDDCAKGFLLDGFPRTIPQADAMASSGISIDHVVEIDVPDEEIVKRMGGRRVHPGSGRVYHIVFNQPKVEGKDDVTGEELAIRPDDEESTVRKRLAIYHEQTKPLVEYYGKVAAAGHSTYSKFDGTQSVAAVSEQIVTALS
>NC_009831.1|WP_012143185.1|3446670_3447516_-|tetratricopeptide-repeat-protein
METVLELTKENIQQIVDVSMKQLVVLSFWSQQSPESVALCQTLTSMAQKQSGRFVLAKVDCDKEMEIANYFQIQNVPTTLVLSEGKPIDGFAGSQDEGQISAMLDKHLPAQWELQLNQAKNHLALHEFEPALVLLKQAFAESPNAEVALVYADAQLMAGDLVTATQLLDSVGLADQDSYYQSLKAKLALALDAADTPEIRQLQQAFDSEPSNIAVLMELVKALHQAKRNEEALGLLFTPLSKDITIENGDAKKLFLEILTALGQGNALANQYRRKLYSLLY
>NC_009831.1|WP_012143186.1|3447639_3449556_-|molecular-chaperone-HtpG
MSQQETHGFQTEVKQLLNLMIHSLYSNKEIFLRELVSNAADASDKLRYEALTNDALYEGDGELRVRISTNKEKGTVTIEDNGIGMTRDTVIEHLGTIAKSGTADFFKNLSGDESKDSQLIGQFGVGFYSSFIVADKVTVRTRAAGHGSDEGVQWESAGEGDFTVDTIVKETRGTEIVLHLREEEKEFADDYRLRSIITKYSDHISVPVEMWEEGTPAIEATEEQEAVAATDGQWQSMNKATALWTRNKSDVSKEEYEEFYKHISHDFTDPLLWSHNRVEGKQEYTSLLYIPSKAPWDMWNRDRKHGLKLFVQRVFVMDDAEQFMPSYLRFVQGLIDSNDLPLNVSREILQDNKVTTALRTAVTKRVLGMLEKLAKNDAEKYQTFWAEFGQVLKEGPAEDMVNKERIAGLLRFASTHTEDAAPTVSLADYVSRMQEGQSKIYYIVADSHEAAANSPHLELLRKKGIEVVLMSERIDEWLINHLTDFDGKQLHSVTRGDLELGDLEDAGEKEAQEKLETESEGLVKRIKDSLGEKVSAVKVTTRLTDTPACVVAGEGEMSTQMIKLMEAAGQAVPESKPTFEINPEHPLVARLNDEQDEALFAQWSDLLLQQAQLSEKGSLADPSAFIKLMNEMLLAKLK
>NC_009831.1|WP_012143187.1|3449752_3450352_-|recombination-protein-RecR
MKFSPLVDELIQSLKCLPGVGPKSAQRMAFQLLERDRKAGQTLAQALASAMSDVGHCRSCRTFTEESHCPICASNKRGQSEQICVVETPADVLAIEAGGHFSGRYFVLLGHLSPLDGVGPEELGLSLLEEHLCSGGVSELILATNPTVEGDATAHFIADMAKVHNVSVSRIAHGVPVGGELEYVDSTTLALSFNGRLPI

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Crispr_ID: NC_009831_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009831_6

4447498-4447580

Orphan

Consensus_repeat	Method
GTTAATATTTACTCTGACCCCATATATTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_009831_6

>merge|NC_009831|6|4447498-4447580|CRISPRCasFinder
GTTAATATTTACTCTGACCCCATATATTCAATGTGAGCTCCCCTGACAAGGCGGGTTAATATTTACTCTGACCCCATATATTC

>NC_009831|6|6|4447498-4447580|CRISPRCasFinder
GTTAATATTTACTCTGACCCCATATATTC	AATGTGAGCTCCCCTGACAAGGCGG
GTTAATATTTACTCTGACCCCATATATTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_009831.1\|WP_041422312.1\|4440034_4441363_-\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|234607
NC_009831.1\|WP_012143981.1\|4443520_4445563_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|312032
NC_009831.1\|WP_012143983.1\|4446254_4447106_-\|HDOD-domain-containing-protein	unknown	unknown	gnl\|CDD\|370050
NC_009831.1\|WP_083758962.1\|4436361_4436997_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|225040
NC_009831.1\|WP_150104451.1\|4437394_4438018_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379235
NC_009831.1\|WP_012143989.1\|4455238_4455487_-\|DUF3297-family-protein	unknown	unknown	gnl\|CDD\|371696
NC_009831.1\|WP_012143974.1\|4435447_4436359_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012143978.1\|4438821_4439874_+\|alkene-reductase	unknown	unknown	gnl\|CDD\|239243
NC_009831.1\|WP_012143990.1\|4455767_4456874_-\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|162579
NC_009831.1\|WP_012143982.1\|4445691_4446123_-\|ribosome-recycling-factor-family-protein	unknown	unknown	gnl\|CDD\|378887
NC_009831.1\|WP_012143986.1\|4449923_4450997_-\|DUF3083-family-protein	unknown	unknown	gnl\|CDD\|314264
NC_009831.1\|WP_012143984.1\|4447918_4449370_+\|DUF3360-family-protein	unknown	unknown	gnl\|CDD\|288673
NC_009831.1\|WP_012143980.1\|4441835_4443080_-\|DUF2325-domain-containing-protein	unknown	unknown	gnl\|CDD\|378383
NC_009831.1\|WP_012143988.1\|4454309_4455041_+\|nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|350167
NC_009831.1\|WP_012143992.1\|4458250_4461403_+\|nucleoside-phosphorylase-like-protein	unknown	unknown	gnl\|CDD\|350159
NC_009831.1\|WP_012143977.1\|4438098_4438680_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_009831.1\|WP_012143993.1\|4461512_4462556_+\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012143987.1\|4451667_4453221_-\|ammonia-forming-cytochrome-c-nitrite-reductase-subunit-c552	unknown	unknown	gnl\|CDD\|236854
NC_009831.1\|WP_012143991.1\|4457153_4457591_+\|cytidine/deoxycytidylate-deaminase-family-protein	unknown	unknown	gnl\|CDD\|225042
NC_009831.1\|WP_041422315.1\|4449441_4449678_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_009831.1\|WP_041422312.1\|4440034_4441363_-\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	1.83888e-132
NC_009831.1\|WP_012143981.1\|4443520_4445563_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	2.54119e-11
NC_009831.1\|WP_012143983.1\|4446254_4447106_-\|HDOD-domain-containing-protein	gnl\|CDD\|370050	pfam08668, HDOD, HDOD domain.	5.02146e-47
NC_009831.1\|WP_083758962.1\|4436361_4436997_-\|metallophosphoesterase	gnl\|CDD\|225040	COG2129, COG2129, Predicted phosphoesterases, related to the Icc protein [General function prediction only].	1.97858e-11
NC_009831.1\|WP_150104451.1\|4437394_4438018_+\|AAA-family-ATPase	gnl\|CDD\|379235	pfam13521, AAA_28, AAA domain.	8.66964e-18
NC_009831.1\|WP_012143989.1\|4455238_4455487_-\|DUF3297-family-protein	gnl\|CDD\|371696	pfam11730, DUF3297, Protein of unknown function (DUF3297). This family is expressed in Proteobacteria and Actinobacteria. The function is not known.	2.2757e-44
NC_009831.1\|WP_012143978.1\|4438821_4439874_+\|alkene-reductase	gnl\|CDD\|239243	cd02933, OYE_like_FMN, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include 12-oxophytodienoate reductase, pentaerythritol tetranitrate reductase, morphinone reductase, and related enzymes.	9.80514e-168
NC_009831.1\|WP_012143990.1\|4455767_4456874_-\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|162579	TIGR01883, Uncharacterized_protein_YqjE, peptidase T-like protein. This model represents a clade of enzymes closely related to Peptidase T, an aminotripeptidase found in bacteria. This clade consists of gram positive bacteria of which several additionally contain a Peptidase T gene.	2.00565e-147
NC_009831.1\|WP_012143982.1\|4445691_4446123_-\|ribosome-recycling-factor-family-protein	gnl\|CDD\|378887	pfam12614, RRF_GI, Ribosome recycling factor. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 130 amino acids in length. There are two conserved sequence motifs: LPS and LKR. Overproduction of ribosome recycling factor (RRF) reduces tna operon expression and increases the rate of cleavage of TnaC-tRNA(2)(Pro), relieving the growth inhibition associated with plasmid-mediated tnaC overexpression.	1.38985e-63
NC_009831.1\|WP_012143986.1\|4449923_4450997_-\|DUF3083-family-protein	gnl\|CDD\|314264	pfam11281, DUF3083, Protein of unknown function (DUF3083). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	6.92043e-172
NC_009831.1\|WP_012143984.1\|4447918_4449370_+\|DUF3360-family-protein	gnl\|CDD\|288673	pfam11840, DUF3360, Protein of unknown function (DUF3360). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 489 to 517 amino acids in length.	0
NC_009831.1\|WP_012143980.1\|4441835_4443080_-\|DUF2325-domain-containing-protein	gnl\|CDD\|378383	pfam10087, DUF2325, Uncharacterized protein conserved in bacteria (DUF2325). Members of this family of hypothetical bacterial proteins have no known function.	1.23266e-30
NC_009831.1\|WP_012143988.1\|4454309_4455041_+\|nucleoside-phosphorylase	gnl\|CDD\|350167	cd17767, UP_EcUdp-like, uridine phosphorylases similar to Escherichia coli Udp and related phosphorylases. Uridine phosphorylase (UP) is specific for pyrimidines, and is involved in pyrimidine salvage and in the maintenance of uridine homeostasis. In addition to E. coli Udp, this subfamily includes Shewanella oneidensis MR-1 UP and Plasmodium falciparum purine nucleoside phosphorylase (PfPNP). PfPNP is an outlier in terms of genetic distance from the other families of PNPs. PfPNP is catalytically active for inosine and guanosine, and in addition, has a weak UP activity. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	7.12061e-99
NC_009831.1\|WP_012143992.1\|4458250_4461403_+\|nucleoside-phosphorylase-like-protein	gnl\|CDD\|350159	cd09008, MTAN, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases. This subfamily includes both bacterial and plant 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidases (MTANs): bacterial MTANs show comparable efficiency in hydrolyzing MTA and SAH, while plant enzymes are highly specific for MTA and are unable to metabolize SAH or show significantly reduced activity towards SAH. MTAN is involved in methionine and S-adenosyl-methionine recycling, polyamine biosynthesis, and bacterial quorum sensing. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	1.52046e-24
NC_009831.1\|WP_012143977.1\|4438098_4438680_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.02709e-10
NC_009831.1\|WP_012143991.1\|4457153_4457591_+\|cytidine/deoxycytidylate-deaminase-family-protein	gnl\|CDD\|225042	COG2131, ComEB, Deoxycytidylate deaminase [Nucleotide transport and metabolism].	1.66845e-50
NC_009831.1\|WP_012143987.1\|4451667_4453221_-\|ammonia-forming-cytochrome-c-nitrite-reductase-subunit-c552	gnl\|CDD\|236854	PRK11125, nrfA, ammonia-forming cytochrome c nitrite reductase.	6.05528e-134

>NC_009831.1|WP_012143983.1|4446254_4447106_-|HDOD-domain-containing-protein
MSTSPLDYAKQAQKICVLSDVYITLNRMLSSDDCSMEELADAIAYEPAIAASILKIANSAMFSMPREIDNLSKALVLLGIKEVKKLVNAYGVTAAFSSIDPKVVDVDKFWEISVDCALICQYFAKNKDTPDTDNIFLSGLFHNLGMLAIVHSEPDKVRYCEGYDRDETPWLRQSEVFGFTFADCTTELLKLWNLPDTIIQPISQFNRAEGEPLPDNSKLLYIASRLAVINAEPGLYAKEELINPDILEDLGISLDEINESLEYCNLQGIQLLATFPIQGRTRE
>NC_009831.1|WP_012143982.1|4445691_4446123_-|ribosome-recycling-factor-family-protein
MNEAITIPLPSLIHRIGREAVKQAQGVAKQYHCELKRVRRSRNWGLSGEAIKIQSFTAQLKTEQLKAAQLKAAQLQREGGEFRYLIQKIETALLDHTDKLEPLEAKLARLINDNPNITLSELIHTTDCTMSEARTARFNADSW
>NC_009831.1|WP_012143981.1|4443520_4445563_+|alpha/beta-fold-hydrolase
MIKDKFPLIATTIIATSMLSACGGSGSKTETTGTGVTDPIKSYKPIECKAMLSASQLALLTPGSGCGYLSVPEKHALYGQPASEKNIEIAVIKLASTSSEKKADPLVYLQGGPGGNASASIGQVVTSNTLIKNRDIYLVDQRGTGYSKPALFCTEYSGEAGTPEQLQACKARLEKAGVDLNAYNSVQNAHDFIQLRKALSIPEWNLYGISYGTRLATTIMRENNSEGIRSVILDGMFPIEVNGISDTPWANYESLNQIVKNCDNTDSCPADDLKAVIEDIIARMHNEGMVAESRVFIQNLLELIKEPAIINYLLAVNEDIGKYRSALASLMADQDDEQDGGGERAGDEESDEEELFYGAMGLSTVCAEEYPFLNTTALSDDNSQGWSASTQVAVNGMYHMGFDKSSCQAWNVAPANDVETQAVASTLPVLILNGQNDTQTPAAWGSLVAKNMLNAQNITNPQGEHGQLMAGFSCFDTIADEFLAEPNKTVDASCVSEIPAVSYEGGGGEEKSASFTFKNGDTSSDTVYMNGVIGSDTLDVMQTLLNSYPQIKTIVMQNVPGSMDDDTNLLASMEIRKRGIATHIPADGMVASGGTDMFLAGVKRTAEAGAKLGVHSWSDGSGKVALDYPRDHQTHVKYLDYYKAVGIDTSFYWYTLEAAPADGIHWMTAEEIAQYGVLTE
>NC_009831.1|WP_012143980.1|4441835_4443080_-|DUF2325-domain-containing-protein
MCDAPATATGAEVFNGFKGKRKLWELTSKLLCPVIGTCLTTSEIRKLAQKVVDKEQARKSDYWLHTWVVSNCDSKHHLSLTVQKHLDKKFAAAIKRFGLLKCRDELKQLWQQHIDRGASAEALWALLTHPLCDLAMQDMAYETIHMLSHQIGAGQRADLKRLHEAEKELVELRKALDKSQQKAHQTISNKECQLDTLQRQVAELKADNLRLKEHNQRLELGGDSSALAPQLQQLRNELASTSSSVEILDRQKVQWQQKLRQSEENILDLTQKLRQREQETRALEGFVKQSLSPCNGCSADSCRDCPDLKGQKILCVGGMHRMTDQYRELVSRCNGEFSHHDGGVEDRSKRLDALLWSADAVICASDCISHDAYYRLKRFCKQHNKRHLFIPSSGISSFAKAMDDVANGVSCISL
>NC_009831.1|WP_041422312.1|4440034_4441363_-|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme
MSNANKPATNALLKQAHNNMPLGVADSYRYWGEENTVFVKSSQGCTITDADDQQFIDFRLAYGPIILGYRDTRVDQEVVAAITERGTISGFSTDLDSQVVELIKQMCPNIEKVRFANSGTEAVIGAVRTARGFTHRNKIVVVEGGFHGLYDEMMWKSDVDNWDSETEAAPKVTAFGGGIPEASREHLETVPLNDFAAIDEVFTRVGDDIAAIVIEPILGNCGSIASTQEYMQKLRDICDANGTLLIMDEVKTGFRVAKGGAQELYGIHADLTTYAKAMGNGYPVAAFGGRKDVMDVISFGKNGVTHGGTYTANMIALSAAKATLTILNETNAYDTINKAGVDIQQVLSRVFTKHGIEHKFAGPDAMFGIHFGSQVPHNYRDWKKTDSDLYTEFAHNLIKSGIMLEPDSREPWFICESHKDIDLAKLEEIADAAMAKAIADRK
>NC_009831.1|WP_012143978.1|4438821_4439874_+|alkene-reductase
MTDNLFQPFALNETITLQNRILMAPLTRCMADEELVPTQAMAEYYTRRAEAGLIISEAVLIRPDGQGYPNTPGLFTPAQIDGWRVVTDAVHKAGGKIFAQLWHTGRVAHPHFFEKSGSTQVIAPSAVGLEGSLPRMRELNYHVPKAVSHDEIVQLVADYAQAAANAIDAGFDGVEIHGANGYLIDQFLHHDSNRRTDEYGQTAENMARFPLAVVDAISARIGNDRTGLRVSPGAYVNMAGDSRDRAVFDYLLAELELRDLAFLHIGIFDDAMEFDYLGGSASSYVRSIYSKTLVGVGSYSAEMGSAAIAADKFDLLAIGRPFIANPDYVARVREGDELVEYSDEMLTSLV
>NC_009831.1|WP_012143977.1|4438098_4438680_-|TetR/AcrR-family-transcriptional-regulator
MRNAEFDREKVLRSAMTAFMDKGYGKTSMQDLTKATGLHPGSIYCAFDNKRGLLLAALEQYKADRSAEFQRFFSGNKPVLVELKAYLDNTVQECISCEAAKACLLTKALNEMAQQDEEVQEIIMANLANWQQGLADVFELAQAKGELSAKRDSQHLARFLAMGIYGLRTFAHTHPQGETLQELADQLFQDICA
>NC_009831.1|WP_150104451.1|4437394_4438018_+|AAA-family-ATPase
MTRQIKIVVTGGPGGGKTTALDLFRRELGDTVAIVPESATVLFSGGIGRSCDEQVVKNVQKTIFSLQQNVENIQEKQYPDRFLICDRGTLDGLAYWPGTEDEFFEEVGSTIEKELSRYDAVIFFESAAASGRDIQSNNPIRNESSTQAAALDKKLQSIWSRHPSYYFVGNSESFVKKIMFGIMTIENVINRHNGGYVGPSFVPNLSK
>NC_009831.1|WP_083758962.1|4436361_4436997_-|metallophosphoesterase
MKLLHVSDLHFNQAQFEWVSEQASHYDVLCISGDLLDDSWHQTASSEEQIDWITQWTLTLQLPTFICSGNHDQLQLENNEQPSAHWLRNLKSNQLYLDNNIIDLGSYRFGCIPYENPNFHHFRDCDVLLHHVPPSKLKVAKQGGDDWGCPDIRAAIQFGELQAKYILCGHVHHPKARFSKFKNKFISNPGNNPSSEKPNFNSINLTAVSEK
>NC_009831.1|WP_012143974.1|4435447_4436359_-|hypothetical-protein
MTKQFARKFALNQLSDPKPEWWKELLLRLKPAGKELSSNGLRLAVRDNYLNFYHKGQAIAKVGFNQGRELYSEQHIKYVFEGASTQNYPRLTGSDPTLINPVKTEETEQYLGGQTLDLWIERSKTHKGDEKTFVEEIAAANSNVIDMEMGLPGSAYRIDLVALERHGGGARLVLWEAKLTTDKRCRTNSEKPEVLEQLARYRDFLTDENRQEQLQKAYVTACQVLVKITELAGKSIAPIIKDVATGQLPLTIDSEPRLLLYYNSEGDVRNSWPRHEERLRKNRVVMQVMTDSTGYKLQSGEQC
>NC_009831.1|WP_012143984.1|4447918_4449370_+|DUF3360-family-protein
MSIEQATYKQRRRKASEFESRSAYLEHELSIMDLKRWRVNLPFRDFGIEIEDWVPAVAATIGKVVMVAAMVAAFASQFGLSQEFVAENTRFELLIAGVIFVVFFSAILNPLSNLAGTHGPMIPLIPLIAAAGGHPLALGIMVGLFGLILSATKGGSRLVKLTGEGVRGGLLIYLGAVGLIGQLSKFESWAISSAQDAVPFVVILTSIIIYAYLAKIEKRWLAIPLCSLIAGVVAFAMGVPFEFVTEPGLPNMNPFYWWGETTGWQLGWPQLEHYIAVIPFAILAVAMWSPDFLGHRVFQELNYPKSAKGTLMNVDDTMAVCSIRQIVGAGLGGGNLASSWGTYMIPAAIAKRPIPGGALLTGLLCVLTAVLGFPMDLAMWEPVLRVALLVGVFLPLLEAGMQMVKCSRNSQSAGICMFACALVNPVFGWALTMVLDNLGLIGNKERADSLSRTDKLIIPVAALIICVGSLALVGQLPGIPALL
>NC_009831.1|WP_041422315.1|4449441_4449678_-|hypothetical-protein
MTDDKLILLLKCCIAVGLGLISLGIYFHNYSDTVEAMGVKGIIISAMCVAFGMALSLPTKMYLTFILVKRETERKEQD
>NC_009831.1|WP_012143986.1|4449923_4450997_-|DUF3083-family-protein
MALRHQQKVYLPKDVRSNQYITAEIIVTDALLAHYTDYKTCYQTLSRAIFNLAEQEELYNIHVITNDKLPVVRFHTEAYCFPTAEQIIFFYNPEYHEAQTLHSQDDYRARKIRIVLLATGEEIRSNSANFHIKVQSFLAKLMPQLPEKDLKIKIRDHQHLSYDLFAKAKGNKESYGYKLRSISDRYKARQCPLPEGHGSLCYVTVKLPLSRKLKQALLPTHTDDFTPLYKKLEDTFIQAASGNKLNRIAMVANGLTPLVRNSKFDQVDGTDEVQMLGFDPNIEEQQYIRHWDGNRLVETVNFTIAAGVKDSKDDGLSRYLNRVEDALKSLTSELALDKSREELIVRFHQHISYKAPE
>NC_009831.1|WP_012143987.1|4451667_4453221_-|ammonia-forming-cytochrome-c-nitrite-reductase-subunit-c552
MKIKKLAIAVMLSTVFTGYSMATEVDLYKSENWKKQFPEQYTTWAETEETTPESGKLDDFLASNPNLVSAWAGYGFAKDYNRARGHQFAMTDIIKTLRTGHPVVGHDGKVVGEAMPANCWSCKTPDIARMYDKVGEANFSDNSWSTWGHEMSNSIGCADCHELGSDEIRISRPYAARAMKSIGKDFSKQTQTMQASQTCAQCHIEYYFEGSDSKKVRYPWDHWVPGVKTDYKEVVNYTGTDGLYQGFAAEAKLAYYDQRNFKDWTNAISGVPSLKAQHPEYENMLDRTEHAMDNHLEFGCTTCHMPKATNKAGAKYSNHKVTFDAEQLPESCLSCHEGADFEEIFDERKAEIKKLRFTADGTDPRLTEAHFKAQAIWSANGIKGLEAGKSIGEAKGNYEAALKAGTPLAAEMDSLLTKIRHGQWFWDSATASHGIHAHNPTEAVRLLKKSNSILDEAIAEADLLLTKYAPNYVYDGSKYDTKAKVQPLAGLNFEAMKTSKDNFIEKRVEKEWPVDLK
>NC_009831.1|WP_012143988.1|4454309_4455041_+|nucleoside-phosphorylase
MSKQPHIAVSPQQVAEHVIVCGEPDRVNRISALLEQVELLADNREFRLMNGLYQGKLITVCSTGVGAPSAIIALEELNLCGAKYVVRVGSAGALQHDIALGELIVAEAAVRDEGGSKAYVASEFPACANRHLLFGIEAYLVENNYPAHVGLVRSHDSFYRDDEDSICQLWSQKGVLGADMETSALLTVGRLRGLKVASILNNVVLYQQDVQDGVNQYVNADNVMMQGELVASRAALHALWLQP
>NC_009831.1|WP_012143989.1|4455238_4455487_-|DUF3297-family-protein
MTDTTSQPALPDRLSVNPRSPHHVAEIFEHEIGIKVNGKERFDVEEYCVSEGWVKVPTHKALDRRGQPLMMTVKGTVEAFYK
>NC_009831.1|WP_012143990.1|4455767_4456874_-|M20/M25/M40-family-metallo-hydrolase
MTNINQQRLVEHFLSLVKIDSESGNEKAVAETLVEQLGQLGFEVTQLSVPGTISNGFNIYAKLQGSLEGSIIFSSHMDTVTPGNGIEPIIEDGVISAKGDTILGGDDKSGIAAVMEAVRAIQESGDAHKTIEVAFTVYEERGMHGSKNFDMSKIESNQAIVLDSGGPIGTIITTAPGQQSLKVTIKGKPAHAGLEPEAGINALTVAADAISKMQLSRIDEETTANIGVVQGGQATNIVMPELHIEAEARSLNDDKLAKQVEHMVSTFESAAQKHGAGIEIASSRSYNAYHISDDDAHVTEIKAAFEAIGIEAVTKPTGGGSDANIFNEKGLKTVNLSTGMSKVHTTDEFIAVADLVSITEFIRSYLTR
>NC_009831.1|WP_012143991.1|4457153_4457591_+|cytidine/deoxycytidylate-deaminase-family-protein
MMTKWAIRFLQMAELVASWSKDPSTQVGAVITENNRIVSLGFNGYPHGISDSAETDNREMKLLKTLHAEENAILHAKRDLSSCEIWVTHFPCPNCAAKIIQTGLRAVHSPQPSEDFLSRWGDKIKVSQDMFDQAGVQVDWMQVES
>NC_009831.1|WP_012143992.1|4458250_4461403_+|nucleoside-phosphorylase-like-protein
MSIYQEVELSELNESYDIDFLIITATTVELNAAIEFLTPIEDDILQAYYNANTYYIGLFGNFICAIVKTNSMGAISSGASLQTTQESIAALTPKAIIMGGIALGKEKDKQKLGDILVSKSVVFYEQARVNDNGSIEYRGIKPEANRTLINRLTQNSTHDYLFNNKNKDATVISGPILSGEKLIDNNQFKQKLLSHFPDAIGGEMEAHGVYVACHDKNVPWIIVKTICDWADGHKEKSFQSESAYIAFSFIHRALESKFAFSNLKILPFKKKRDSPEVNLDAINILPLLVSRRDLSKVLSNREIIKDSSKKVYYEYFFFENRGRVEGFLFIGKNVTITNTLDSFVSTFEKPKILNVYVTKKYNATGPIDRISHLNKETAKRQLSATIYDGIQYLEETIWDSTFKSYDDTKHHKRSDYIDQSLYTYHEDDTNLGHGTEYFKSILADKMGSSISIIFGSGGVGKTTLCDALKSDIERDSDVRKKGVFLIRGERTSSLKNFHDIYVESLLDLFEAFKEESNLSNLSTNDFSINYACGNIQVIIDGLDEIDSALGERFNLERFFQSLSDLDERFHNTKIILTTRDYFAKNLVSSSPLIKKFKLNGFTEGDIEKFKKIKLKTDSQRTKFDKLLESKKLRKGSFSLPVIINLACQAVLGDGPHNKSYNENSEYLISDHVYDSILDYMLNREIEKQKINCTVDDLFLLLVEIVTSHNNKISTSELKEYVELSFNETVNKFLRNPIFSVTSDFISIKEEALCSLVRCRYARYLLLKNISLTEKISELLKDSYKGNGEIYSSLVDTIDTNNEKFIENSTKLLKQMSHKESHSTSNYEKSKYKKSISAMLYILMSNRNCDNKPDRSNFLLQIKGSTTNTTSIDGLHIYGEFHTLDFSNITITNSYFSEFEKFEDCIFPSESKVVFSYCEFNKITLKKANNIKTDIFEASCKFEDCNIMSEIKNQQDDDCIKQKRVRDNIVSISRYIDTTQRSSNLIKLNTSVKWSKSHKGFLKSLISESFLEFTNKGLYKINHDYYDNLPDIKLGRFPDKLDEIVAKLAKK
>NC_009831.1|WP_012143993.1|4461512_4462556_+|hypothetical-protein
MTSARRTLIDPESTPFYHIINRCVRRAFLCGEDKLTGKSYEHRRGWIVDKVKALSTIFCIDICAYAVMNNHYHLVLKIDTDKAKSLSNKEVISRWCKVTKGHAVATKYMNGETLIEGEPLLLDSLLAEWHERLSSISWFMRCLNEEIARRANREDECKGAFWEGRFKSQALLDEQALLACMMYVDLNPIRAGIADTVQTSDFTSIQERIAELNSLDTNACNPLSPTAQEPELAAGEPPKPLAEFDGSTHLATQSGIPFHFCDYLQLIDWTGRAIRNDKRGFIDSNRPKLLNELGISPDAWITSAKEFRRQYSGISGRWDAMCEFKKQHQSGKWCKGKACSNALHPSP

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Crispr_ID: NC_009831_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009831_7

4484888-4485002

Orphan

Consensus_repeat	Method
AACATTCGCGGCTAAAGCCACTCCTACAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_009831_7

>merge|NC_009831|7|4484888-4485002|CRISPRCasFinder
AACATTCGCGGCTAAAGCCACTCCTACATTGAGACCCCTTCCCGTCATTCTGAACTTGTTTCAGAATCCAAAAAAAGCAACGAGAGAACATTCGCGGCTAAAGCCACTCCTACAT

>NC_009831|7|7|4484888-4485002|CRISPRCasFinder
AACATTCGCGGCTAAAGCCACTCCTACAT	TGAGACCCCTTCCCGTCATTCTGAACTTGTTTCAGAATCCAAAAAAAGCAACGAGAG
AACATTCGCGGCTAAAGCCACTCCTACAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_009831.1\|WP_012144021.1\|4489963_4490482_+\|copper-resistance-protein-NlpE-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377235
NC_009831.1\|WP_012144008.1\|4479157_4479547_-\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NC_009831.1\|WP_012144009.1\|4479955_4481050_-\|glycine-cleavage-system-aminomethyltransferase-GcvT	unknown	unknown	gnl\|CDD\|234742
NC_009831.1\|WP_150104364.1\|4492019_4492565_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|225076
NC_009831.1\|WP_012144007.1\|4476115_4479004_-\|aminomethyl-transferring-glycine-dehydrogenase	unknown	unknown	gnl\|CDD\|235432
NC_009831.1\|WP_012144011.1\|4482634_4483882_-\|2-octaprenyl-6-methoxyphenyl-hydroxylase	unknown	unknown	gnl\|CDD\|235584
NC_009831.1\|WP_012144023.1\|4491368_4491929_+\|type-II-secretion-system-protein	unknown	unknown	gnl\|CDD\|225076
NC_009831.1\|WP_150104455.1\|4489240_4489915_+\|5-formyltetrahydrofolate-cyclo-ligase	unknown	unknown	gnl\|CDD\|182385
NC_009831.1\|WP_150104454.1\|4487786_4488068_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012144014.1\|4485950_4486199_-\|YgjV-family-protein	unknown	unknown	unknown
NC_009831.1\|WP_049772135.1\|4472906_4474556_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_009831.1\|WP_012144013.1\|4485165_4485474_+\|cell-division-protein-ZapA	unknown	unknown	gnl\|CDD\|182874
NC_009831.1\|WP_012144017.1\|4487016_4487679_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_009831.1\|WP_012144010.1\|4481363_4482578_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|236341
NC_009831.1\|WP_012144003.1\|4470208_4471909_+\|Na(+)/H(+)-antiporter-subunit-D	unknown	unknown	gnl\|CDD\|237168
NC_009831.1\|WP_012144022.1\|4490465_4491134_-\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NC_009831.1\|WP_012144004.1\|4472035_4472722_+\|transposase	unknown	unknown	gnl\|CDD\|224854
NC_009831.1\|WP_012144012.1\|4484017_4484584_-\|UPF0149-family-protein	unknown	unknown	gnl\|CDD\|234976
NC_009831.1\|WP_150104453.1\|4474753_4475155_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_041421807.1\|4488443_4489160_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736

Protein	Function_ID	Function_description	E-value
NC_009831.1\|WP_012144021.1\|4489963_4490482_+\|copper-resistance-protein-NlpE-N-terminal-domain-containing-protein	gnl\|CDD\|377235	pfam04170, NlpE, NlpE N-terminal domain. This family represents a bacterial outer membrane lipoprotein that is necessary for signalling by the Cpx pathway. This pathway responds to cell envelope disturbances and increases the expression of periplasmic protein folding and degradation factors. While the molecular function of the NlpE protein is unknown, it may be involved in detecting bacterial adhesion to abiotic surfaces. In Escherichia coli and Salmonella typhi, NlpE is also known to confer copper tolerance in copper-sensitive strains of Escherichia coli, and may be involved in copper efflux and delivery of copper to copper-dependent enzymes.	6.78782e-33
NC_009831.1\|WP_012144008.1\|4479157_4479547_-\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	1.29194e-72
NC_009831.1\|WP_012144017.1\|4487016_4487679_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	7.98534e-11
NC_009831.1\|WP_150104364.1\|4492019_4492565_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	3.3274e-09
NC_009831.1\|WP_012144007.1\|4476115_4479004_-\|aminomethyl-transferring-glycine-dehydrogenase	gnl\|CDD\|235432	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase.	0
NC_009831.1\|WP_012144011.1\|4482634_4483882_-\|2-octaprenyl-6-methoxyphenyl-hydroxylase	gnl\|CDD\|235584	PRK05732, PRK05732, 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated.	1.42139e-173
NC_009831.1\|WP_012144023.1\|4491368_4491929_+\|type-II-secretion-system-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	4.46056e-09
NC_009831.1\|WP_150104455.1\|4489240_4489915_+\|5-formyltetrahydrofolate-cyclo-ligase	gnl\|CDD\|182385	PRK10333, PRK10333, 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional.	1.59998e-71
NC_009831.1\|WP_012144022.1\|4490465_4491134_-\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	1.07254e-141
NC_009831.1\|WP_049772135.1\|4472906_4474556_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.69533e-60
NC_009831.1\|WP_012144013.1\|4485165_4485474_+\|cell-division-protein-ZapA	gnl\|CDD\|182874	PRK10972, PRK10972, cell division protein ZapA.	2.75705e-21
NC_009831.1\|WP_012144010.1\|4481363_4482578_-\|FAD-dependent-monooxygenase	gnl\|CDD\|236341	PRK08850, PRK08850, 2-octaprenyl-6-methoxyphenol hydroxylase; Validated.	0
NC_009831.1\|WP_012144003.1\|4470208_4471909_+\|Na(+)/H(+)-antiporter-subunit-D	gnl\|CDD\|237168	PRK12668, PRK12668, Na(+)/H(+) antiporter subunit D.	0
NC_009831.1\|WP_012144004.1\|4472035_4472722_+\|transposase	gnl\|CDD\|224854	COG1943, COG1943, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	5.60589e-14
NC_009831.1\|WP_012144012.1\|4484017_4484584_-\|UPF0149-family-protein	gnl\|CDD\|234976	PRK01736, PRK01736, hypothetical protein; Reviewed.	6.21176e-43
NC_009831.1\|WP_012144009.1\|4479955_4481050_-\|glycine-cleavage-system-aminomethyltransferase-GcvT	gnl\|CDD\|234742	PRK00389, gcvT, glycine cleavage system aminomethyltransferase GcvT.	0
NC_009831.1\|WP_041421807.1\|4488443_4489160_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	9.92684e-14

>NC_009831.1|WP_012144012.1|4484017_4484584_-|UPF0149-family-protein
MATPPSLRIDNLMAALDAAEIGQQPGEVHGALVGLICGGVEQSKKAWNSTFLELMNDGQPLPDALQQLIDELYQDTLARLSDADFGFTPMLPEEEEPLAKRVEALSLWVQSFLTGIAMVQPKLNRASSDVQEVIKDLAEIALVEFDVADDDESESAYMELMEFSKMAALLCYSEFGPEPTEQEAGVIH
>NC_009831.1|WP_012144011.1|4482634_4483882_-|2-octaprenyl-6-methoxyphenyl-hydroxylase
MKAQTEQDTSQTINVVDVAIVGGAMAGATLALGLKALAKDLQRPLKIALIEAHRPDDNHPGFDARSIAVAHGSIFELNRLGIWPKIAHLGTPIENIHISDRGHFGMTELNADDFYLKYLGQVIELEPVGQVLFKQIADTDIELYCPAKLASVEAQTDAQLLTLDDGTQLSTSLLVAADGVNSKVRQAFKQPLEQVDFDQVALIANVETDTPHEQRAFERFTDSGPLAILPMSKSKGVNRVSLVWALRPDDAERLMSVSKDEFLAELQQAFGYRAGQFTGVGERHSYPLLLSHMPRPIYHRTVFIGNAAQTLHPIAGQGFNLGLRDLVSLLEVLKQTIESEASDELDFGSAQVTHKYLQSREADRSATMTNIEFLVRGFSNDYWPLVAGRSLALRLLSWLPPLKTPIARSAMGWRS
>NC_009831.1|WP_012144010.1|4481363_4482578_-|FAD-dependent-monooxygenase
MLSTQTYDVAIIGGGMVGLATAIGLAMEELRVVVIDAGETHAVSGEARLRVSAINKASQRLLQNLGAWSYLDSERLSPYQKMEVWDKDSLGKIGFDAHSLSEQHLGSIIENDNISFALAKRAAELDQITHLENHRLEKIAFGEREAWLTLDNGDNLSAALVIGADGANSWVREQCKIPMTFWDYGHHAIVASIRTEIPHLDTARQVFLDEGPLAFLPLYESNLCSIVWSVPPAKAKKLLEADKLEFEHTLTAEFDGRMGMCHLEGEPQAFPLRMRYARHFARHRLLLAGDAAHTIHPLAGQGVNLGFLDAAAIIQTIGELKLDGKDIGDYGNLRALERWRKADALEMIAAMEGFKRLFEGSNPVKKALRDFGLNLVDNISPVKTLFMQQAMGNKSSLPKLCKAE
>NC_009831.1|WP_012144009.1|4479955_4481050_-|glycine-cleavage-system-aminomethyltransferase-GcvT
MANKTVLFNKHLESDAKMVDFHGWDMPLNYGSQIEEHNAVRQDAGMFDVSHMTVVDVTGTDACAFLRKLLANDVAKLKVPGKALYGGMLDHNAGVIDDLITYYLTDTHYRVVVNSATREKDLAWIAEQVKGFDVEIVERPELAMIAVQGPNAKAKAATVFNDAQNAAVEGMKPFFGVQADSLFIATTGYTGETGYEIIVPEDEAQALWQGLLEAGVKPCGLGARDTLRLEAGMNLYGLDMDETVNPLAANMGWTIAWEPQDRDFNGREALAAIKAAGTEKLVGLIMEAKGVIRPGMSVFFTDGEGVEQQGTITSGTFSPTLGYSIAMARVPRSIGDTAEVEMRKKRVSVKVVAPSFVRNGKQAF
>NC_009831.1|WP_012144008.1|4479157_4479547_-|glycine-cleavage-system-protein-GcvH
MSNIPAELKYASSHEWIRKEEDGSYTVGISEHAQELLGDMVFIELPDVGDTLSAGEDCAVAESVKAASDIYAPLSGEVLAINEALEDSPELVNSDAFGDGWFFRVMPSDVAEIDSLLDAEGYQAVIDEE
>NC_009831.1|WP_012144007.1|4476115_4479004_-|aminomethyl-transferring-glycine-dehydrogenase
MTTETLTQLEQHELFIRRHIGPDSAQQQEMLNFVGAESLEDLTQQIVPESIRLNRDLAVGSACGEAEGMAYIREIADKNKVFKSYIGMGYYGTEVPSVIQRNVLENPGWYTAYTPYQPEIAQGRLEAILNFQQVSMDLTGLDLASASLLDEATAAAEAMALAKRVSKAKKANIFFVADDVFPQTLDVVKTRAECFGFEIVVGPASEAVNYELFGALFQYTNRFGEITDFTELFTELKAKKAVVSVAADIMSLVMLKSPGSMGADVVFGSAQRFGVPMGLGGPHAAFFVTRDAHKRSLPGRIIGVSQDTRGNRALRMAMQTREQHIRREKANSNICTAQVLLANMASFYAVYHGPQGLKIIAERIHRLTDILASGLTAKGVELVNGTWFDTLSLKATDSEAITARAVAAGINLRIDSDGVLGVSLAETTLREDIAELFDVILGEGHGLDVAALDAEIIKAGSSSIPAQLVRTDAILTHPTFNSYHSETEMMRYIKRLENKDLALNHSMISLGSCTMKLNAATEMMPISWPEFGNMHPFCPLDQSEGYTDLIEELSTWLVDITGYDAMCMQANSGASGEYAGLLAIRNYHISRGDAHRNVCLIPQSAHGTNPASAQMAGMKIVVTACDKAGNVDMEDLKAKAAEVAENLSCIMITYPSTHGVYEETVSEICEVIHQHGGQVYLDGANMNAQVGLTTPGSIGADVSHLNLHKTFAIPHGGGGPGMGPIGVKAHLAPFVAGHVVVKHGRESDNNGAVSAAPYGSASILPITWMYIKLLGHQGLRQSTQVALLNANYVMKKLSEHYPVLYTGRNERVAHECIIDLRPLKESSGVTEMDIAKRLNDYGFHAPTMSFPVAGTLMIEPTESESKVELDRFIEAMISIRGEASRVESGEWPADNNPLHNAPHTLADIMDPEFDSRPYSREVAVFPTAAVKLNKFWPTVNRIDDVFGDRNLFCACVPMSEYE
>NC_009831.1|WP_150104453.1|4474753_4475155_-|hypothetical-protein
MQQGLPITIAADGRFSNSLKPLLTQLEMWLNFQALKADWYGNEDFVLSFDFTLVRSLDEKMQQLKTARAASAESWIVESGYAYHYESSRLTTIAFIAVDDLIQGGVGIEQAIKARLIAVANSVGSKHGFLALS
>NC_009831.1|WP_049772135.1|4472906_4474556_+|GGDEF-domain-containing-protein
MKKEISSDNDSFSRSITFRLIIIFSLVSLFFGGVNTIVATTKAKNLLTKQIQKQQLTFSKYVSNDIEVEMRKSLNFFTFLAKDLSELNFKTDVGSATKLLEERHVPPIFKYGILLISPDGEELVAESPALPGGTEFIFGQSEWFQRAKLADQAVFSRPFKNRVTHEPSIVIAAPIKNEENKVVAVVAGILELNQTDLFKYLYSSVLEGGSDILVISPKDNLFVASSIPEMVLKPTPEPGRNRLHDMAMRGYRGVGVTVNAYGVEELAAITSIESTGWFVATRQKTTEAYLPVRQLTESMLMYLVLSAILGVLIITFVFITMLSPLKKAALSVKDMAQGNTPLKKLTIVHKDEVGDLIDGFNSLVDAIDGRTDALETANQKLAALSLTDELTGLGNRRHFNEKLEQEWIRASRTKQPLALGMIDIDFFKKYNDKYGHVLGDECLQEISKLLASIISRAGDLSARYGGEEFAFIAPATDEEGARDIAEKFQEALHSLTLPHVESEFGFVTASIGIAVRTPTKGEESICLIKIADEALYLAKEQGRNRVVQL
>NC_009831.1|WP_012144004.1|4472035_4472722_+|transposase
MPRAHRNSPVNIPQHIIQRGNNRQACFASEEDFMLYAKWLKQYASEYQVHIHAWVFMTNHVHILCTPLQPNAISQMMQSLGRQYVRYFNFTYKRTGTLWEGRFKSCLVQTEQYLLQVYRYIELNPVRAEMVAEPSAYKWSSYQINALGKTSTLCTPHQTYLSLASNPTQRQINYRALFKHHIDTQLITQIRNATNKGMAIGNDKFKNEIEALTGESIRPKKRGRPSQK
>NC_009831.1|WP_012144003.1|4470208_4471909_+|Na(+)/H(+)-antiporter-subunit-D
MWMLELPPFTLFFIGGLIAAMTRGKLRGAIMVAIPVISAMHLWTVPEGIHLQLTFLDYELVPYRADKLSLMFGYVFHIAAFISIIYSLHVKDTVQQVAAMLYAGSALGAVFAGDLLTLFVFWELLAFTSVFLIWARRTSRAYHAGMRYLIIQVLSGVILLVGALFYAAEMGSLAFGYIGLESIAGWLILIAFGIKCAFPFAHNWLTDAYPEATPTGTVLLSAFTTKVAVYALARAYPGTELLVYIGAAMTCFPIFFAVIENDLRRVLAYSLINQVGFMVVGIGIGTALAINGAIAHAFNDVIFKGLLFMSMGAVLHMTGRINGSDLGGLYKTMPKTTILCIVGAASISAFPLFSGFVSKSMVMSAALENGYDWIWLMLLFASAGVFHHAGIKIPYFAFFAHDSGLRANDPPGNMLFAMFIAASLCVAIGIYPAALYSLLPYDTGYNPYDATHVLAQTQLLLFSALAFVWLNLRNMYPPELRSTNLDVDWIYRRAIPNVLQKVFAVIWQADGALRQAVSGRLNQCQSFIASKHKGLGGLLSGSYPSGNMVLWVGVLLASYLFIGFVG
>NC_009831.1|WP_012144013.1|4485165_4485474_+|cell-division-protein-ZapA
MSSHAIEISLLGRTYSIACPPGQEGALQHVAQNLEQQLSSLKTRTNNLSREEIAIMAALNIGYELLEEQQKNQDYIKQMDDKIGLLQSTLENALVERSTKDD
>NC_009831.1|WP_012144014.1|4485950_4486199_-|YgjV-family-protein
MMSAEILGYIASGFVGLSLLMGDIKKLRYINLFGCLLFVIYGLNISAYPVAVMNLFCAGINLYHIGVIIKLDRANKHLGASS
>NC_009831.1|WP_012144017.1|4487016_4487679_+|Crp/Fnr-family-transcriptional-regulator
MRYLDRMIQQGFEIFSQNVERPELKVKQMKPQDFILRQGQEISELYWLKSGACTIAYNAENGRRFNLGRLRARSRLFGEIEWLNNSPCQFEVCADEPIELIVLPLNFVTELIESHASIGLWLSHCLSTKYHDGIEFTLAQILYPLSYNIALDLKHRQQGSRPEISFRQLYREAERFGCSERVFRKVVAQLQTLGLVEKVEHQLKILDMEKLEAFIESMEK
>NC_009831.1|WP_150104454.1|4487786_4488068_-|hypothetical-protein
MLGLAAGLAFAGTAVAGFDEKVAASFAAKYQVCALKLKDTPGYRLKALGLKAKSDEIGRDKLGGGGYIEAFQKEKKKAWLLTKKECKRFADRL
>NC_009831.1|WP_041421807.1|4488443_4489160_+|Crp/Fnr-family-transcriptional-regulator
MIDSALSNKLQWRTELSPELINKLLSIAQLRSKLTASELDDSSIAHQGISFILEGTVTICMQTPNLKTVNNIVMGQGDWFGSYDIKNAGYTPFFLTEIEPVRLIHFENSDLQRLAGENIEIYKWFHSLSFEAKAKWLQSQLMMSENLPSRIVYLLIELAAHIPFITGQIPKLSVSQQQISQITGIARQRVNETIKLLEKEKLVHLERGCIYLTDLTGLGNKLEDVDLSIRDPRRSQQR
>NC_009831.1|WP_150104455.1|4489240_4489915_+|5-formyltetrahydrofolate-cyclo-ligase
MVSCFRRAAGQYHKKNIEGSILKPQFSSSPSAKATRTALRAQVRDARRCISDNEQHSFATTATKQILAELTKLKAKHIALYLTNDGELDTQPLIRALWEQGVNLYLPRLHPFSRGNLLFFAYTPETALVENKLKIPEPVLDIGKMILPHQLDAVVTPLVAFDSTGGRMGMGGGFYDRTLANWQKIGKPYPIGFAHDCQQVESLPSEHWDVPLPMIVTPTRVLRF
>NC_009831.1|WP_012144021.1|4489963_4490482_+|copper-resistance-protein-NlpE-N-terminal-domain-containing-protein
MKLQFNARTNLPVLALLALIATATTACSTQPPELKVDIETARSGVDSSASVAQLPLGDNSQNALDWNGIYSGIIPCASCEGIKTLLTLKRDNHYILESEYLGRSDKTFIEQGMFEWNSTGSKITLKQEPTDQKTEKQFQVGENQLFLLDKAENRVTGALADSYRLIKITPAR
>NC_009831.1|WP_012144022.1|4490465_4491134_-|uracil-DNA-glycosylase
MVEHSNWDSFIEAEKLQDYFTQLQAFVSAERAQGKAIFPPQDEVFSAFELTPLDRVRVVIIGQDPYHGPEQAHGLCFSVKHGIKTPPSLVNMYKELVDDIDGFVTPNHGHLSSWAEQGVLMLNTVLTVEQGKAHSHAKSGWETFTTHALELLNRQTTPIVFILWGAHAIKKGKVITAPQHHILSGPHPSPLSAYRGFFGCKHFSKTNDLLELDGSDPITWQV
>NC_009831.1|WP_012144023.1|4491368_4491929_+|type-II-secretion-system-protein
MYSGSLTSIAKTEGFTLIELVVVIIILGILAVVALPKFINVSQDAHLSTVKGTGGAFKSGINLARAVWATRVGSGPADDLPVFGTATEGELDFNDNGWPAQHWGTADSDGDSPKLDNTDDCISVWETIFEGDEPSISDVLDSDDTDYKANYLSPERCRYDYSANSNLSITYNSLDGSVTIDSDPDS
>NC_009831.1|WP_150104364.1|4492019_4492565_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MNNRYSPTQRASGFTLIELVVVIIVLGILAVIALPQFINIKQDAQISTVEGTGGAFAAGIKLANVKWASKGHSGPVDNLQVYDGGNSGQLDINQWGWPAQNYPPFEASPRLNNTNDCMSVWRTILLDAPKVSTSADVADSVYRATYISPDQCKFFFNELPALSIYYDSRDGTVTTDSDPES

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Crispr_ID: NC_009831_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009831_8

4597368-4597477

Orphan

Consensus_repeat	Method
AGATTCGCGGCTAAAGCCGCTCCTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_009831_8

>merge|NC_009831|8|4597368-4597477|CRISPRCasFinder
AGATTCGCGGCTAAAGCCGCTCCTACAGGGGGAATGTCGCACCTCGAATGTCGTGGCTCGTAGCTCGTAACTCGTAGCCCTTAAAGATTCGCGGCTAAAGCCGCTCCTAC

>NC_009831|8|8|4597368-4597477|CRISPRCasFinder
AGATTCGCGGCTAAAGCCGCTCCTAC	AGGGGGAATGTCGCACCTCGAATGTCGTGGCTCGTAGCTCGTAACTCGTAGCCCTTAA
AGATTCGCGGCTAAAGCCGCTCCTAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_009831.1\|WP_012144097.1\|4585577_4586237_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173412
NC_009831.1\|WP_012144108.1\|4598892_4599150_+\|ribosome-alternative-rescue-factor-ArfA	unknown	unknown	gnl\|CDD\|367714
NC_009831.1\|WP_150104367.1\|4588083_4588290_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012144103.1\|4591768_4593175_-\|reductive-dehalogenase	unknown	unknown	gnl\|CDD\|274158
NC_009831.1\|WP_190273173.1\|4588363_4591249_-\|flavodoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|273882
NC_009831.1\|WP_041421821.1\|4606493_4606697_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012144105.1\|4594647_4595529_+\|pirin-family-protein	unknown	unknown	gnl\|CDD\|224655
NC_009831.1\|WP_049772182.1\|4607973_4609050_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197314
NC_009831.1\|WP_012144109.1\|4599631_4600567_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NC_009831.1\|WP_012144106.1\|4595761_4597243_-\|YdiU-family-protein	unknown	unknown	gnl\|CDD\|234583
NC_009831.1\|WP_012144113.1\|4605632_4606121_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012144098.1\|4586598_4586964_-\|response-regulator	unknown	unknown	gnl\|CDD\|381093
NC_009831.1\|WP_012144102.1\|4591481_4591766_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_041421820.1\|4600868_4602197_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_009831.1\|WP_012144099.1\|4587334_4587988_+\|DUF1707-domain-containing-protein	unknown	unknown	gnl\|CDD\|377959
NC_009831.1\|WP_012144104.1\|4593261_4594233_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_009831.1\|WP_012144114.1\|4607040_4607952_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_083758983.1\|4603410_4605180_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225971
NC_009831.1\|WP_012144111.1\|4602284_4603280_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223787
NC_009831.1\|WP_041422341.1\|4597643_4598702_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293810

Protein	Function_ID	Function_description	E-value
NC_009831.1\|WP_012144097.1\|4585577_4586237_-\|hypothetical-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	0.00796333
NC_009831.1\|WP_012144108.1\|4598892_4599150_+\|ribosome-alternative-rescue-factor-ArfA	gnl\|CDD\|367714	pfam03889, DUF331, Domain of unknown function. Members of this family are uncharacterized proteins from a number of bacterial species. The proteins range in size from 50-70 residues.	1.46884e-17
NC_009831.1\|WP_012144103.1\|4591768_4593175_-\|reductive-dehalogenase	gnl\|CDD\|274158	TIGR02486, putative_reductive_dehalogenase_partial, reductive dehalogenase. This model represents a family of corrin and 8-iron Fe-S cluster-containing reductive dehalogenases found primarily in halorespiring microorganisms such as dehalococcoides ethenogenes which contains as many as 17 enzymes of this type with varying substrate ranges. One example of a characterized species is the tetrachloroethene reductive dehalogenase (1.97.1.8) which also acts on trichloroethene converting it to dichloroethene.	8.16086e-52
NC_009831.1\|WP_190273173.1\|4588363_4591249_-\|flavodoxin-domain-containing-protein	gnl\|CDD\|273882	TIGR01931, Sulfite_reductase_flavoprotein_alpha-component, sulfite reductase [NADPH] flavoprotein, alpha-component. This model describes an NADPH-dependent sulfite reductase flavoprotein subunit. Most members of this family are found in Cys biosynthesis gene clusters. The closest homologs below the trusted cutoff are designated as subunits nitrate reductase.	0
NC_009831.1\|WP_012144105.1\|4594647_4595529_+\|pirin-family-protein	gnl\|CDD\|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	6.50545e-68
NC_009831.1\|WP_049772182.1\|4607973_4609050_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197314	cd09080, TDP2, Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains. Human TDP2, also known as TTRAP (TRAF/TNFR-associated factors, and tumor necrosis factor receptor/TNFR-associated protein), is a 5'-tyrosyl DNA phosphodiesterase. It is required for the efficient repair of topoisomerase II-induced DNA double strand breaks. The topoisomerase is covalently linked by a phosphotyrosyl bond to the 5'-terminus of the break. TDP2 cleaves the DNA 5'-phosphodiester bond and restores 5'-phosphate termini, needed for subsequent DNA ligation, and hence repair of the break. TDP2 and 3'-tyrosyl DNA phosphodiesterase (TDP1) are complementary activities; together, they allow cells to remove trapped topoisomerase from both 3'- and 5'-DNA termini. TTRAP has been reported as being involved in apoptosis, embryonic development, and transcriptional regulation, and it may inhibit the activation of nuclear factor-kB. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.	8.76253e-07
NC_009831.1\|WP_012144109.1\|4599631_4600567_+\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.75733e-13
NC_009831.1\|WP_012144098.1\|4586598_4586964_-\|response-regulator	gnl\|CDD\|381093	cd17538, REC_D1_PleD-like, first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains. PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	9.52219e-30
NC_009831.1\|WP_012144106.1\|4595761_4597243_-\|YdiU-family-protein	gnl\|CDD\|234583	PRK00029, PRK00029, YdiU family protein.	0
NC_009831.1\|WP_041421820.1\|4600868_4602197_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	8.66603e-53
NC_009831.1\|WP_012144099.1\|4587334_4587988_+\|DUF1707-domain-containing-protein	gnl\|CDD\|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	1.08278e-05
NC_009831.1\|WP_012144104.1\|4593261_4594233_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.81519e-36
NC_009831.1\|WP_083758983.1\|4603410_4605180_-\|HD-domain-containing-protein	gnl\|CDD\|225971	COG3437, COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms].	1.37187e-75
NC_009831.1\|WP_012144111.1\|4602284_4603280_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	2.33593e-27
NC_009831.1\|WP_041422341.1\|4597643_4598702_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293810	cd07724, POD-like_MBL-fold, ETHE1 (PDO type I), persulfide dioxygenase A (PDOA, PDO type II) and related proteins; MBL-fold metallo-hydrolase domain. Persulfide dioxygenase (PDO, also known as sulfur dioxygenase, SDO, EC 1.13.11.18) is a non-heme iron-dependent oxygenase which catalyzes the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria. Mutations in ethe1 (the human PDO gene) are responsible for a rare autosomal recessive metabolic disorder called ethylmalonic encephalopathy. Arabidopsis thaliana ETHE1 is essential for embryo and endosperm development. Bacterial ETHE1-type PDOs are also called Type 1 PDOs. Type II PDOs (also called PDOAs), are mainly proteobacterial. These enzymes belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	4.6174e-68

>NC_009831.1|WP_012144106.1|4595761_4597243_-|YdiU-family-protein
MSSMEIDLGLTFDNSYAQELEGFYDACLGDRAPSPELVKLNASLAESVGLTNTDTGELAQVFSGSDAPIGASPLAQVYAGHQFGGFTPQLGDGRALLLGEVLDKEGKRLDLQLKGSGPTKFSRRGDGKAVLGAVLREYILSEAMHALNIPTTRALAVVTTGEPVMRTQFLPGAVLTRIASSHLRVGTFQFFSARGEQDKVKQLADYAIARHYPELKESQQPYLDLLCAVRDKQAELVARWLLVGFVHGVMNTDNMTISGETIDYGPCAFMDNYDTNAVFSSIDEQGRYSYNNQPVIAQWNLARLAETLLPLIDVDRDEAIAQATEAVTGFWETFHRCWLAGMRAKLGLSTAQETDLALCEQLLETMSGQEVDFTQLFRQLASDLTSGNSESQTLFKDADKFLLWRASWLARLAQESLSTPERVEMMNGANPLYIPRNHLVEDAIDAAEQEGDYQPFEKLIAVLATPYMQQESADDYTKPAPESFGCYTTYCGT
>NC_009831.1|WP_012144105.1|4594647_4595529_+|pirin-family-protein
MRVINQFSARPAMDGDGVNIRRVADFNNTRFDPFLMLDEIKSDDKQDFIGGFPPHPHRGIETFTYIKKGGFEHRDQLGNVKAIRAKDVQWMSTGSGVIHSEMPLADADEGLHGFQIWVNMPANQKMRPARYEDSSETANPESTNDKGALLRALAGNWAFTGQSSISAPIQDLAGEAAIADLMLSPEAMAELQLDRHEFVGLYLYEGTLIGNNDAQSSDNTLPNDYSAGTYLILDSQDLLKLQAGPDGAGLLLFAGQPIKEKIVHMGPFVMNTQAEIEQTIKDYQEGRFGEIPL
>NC_009831.1|WP_012144104.1|4593261_4594233_-|LysR-family-transcriptional-regulator
MQRRRPPQQQSTPEELASQLRLDEIKLFNLVAKLGSFSAAAKQSGISQPTASRRIRRLEESLSLRLFERTTHTVTLTELGTQFLQHSLQLMANFDSTLSFVRQTREEPAGLLTVGLPLWLLQTIDSRFFAEFLQKYPKIQLNFYNVSPVRLQAESFECDEMDLMLHFFLPADRKMTARPLQAYKLDFFANPNYLARAPTLEHPRQFSQHDCLYVRNPFLQDKGWLWTENGQTNSVIINALTTFETFTPALDWALQGIGVIWCPTPLIDKADPQRQMIKLFDGAYATSLILNAIYPSRRLLSPKVKVFMEELTCFLRSGHAASV
>NC_009831.1|WP_012144103.1|4591768_4593175_-|reductive-dehalogenase
MTTEKDNNSTDAPADPSRRKMFRLSAVAAGIAAVGGAGTFISHRVEGVPFEGGFPMPIDDKVLKPFNQRNWIFSQGGSERNRAEFPNRDKAFSELIGEEDWSFQDGMFAASDYTRSPEQWDNARPGYQQIDWALFCAASHPLEYLGKMAKFGMPDAPGICGWPQKNLAPVKWQFASKKEAATKIKRAAKLFGATRVGITYNDPRWNYEPMYNIFESKEVSWDEYPFKPKTVIVMLHEMDYDAIRTSPSPASVGAVNKGYTDMAVKAGSLADFIRRLGYKAIASHNDSINKVAYGIMAGLGEGARNGALVAPGLGPRVRISAVITDFDFVEYDKPRNFGIMEFCEHCKLCADRCPSKAITFDDKPGFKPTYEGADNPDLAWAGQIGVKKFYNDAKKCFKFWADNTVACTNCIKACPWNKPDFWHHRLIDASNTFTKGPVHTFMKDMDTLFGYGDMDVAKATKLFWNKED
>NC_009831.1|WP_012144102.1|4591481_4591766_-|hypothetical-protein
MMGLQWYLMGVLTIFAWNGYLWLGRHYRLDWKASLGLLISACTLLVCFGWSWASFAEGEARSGAMGLLLFGLGGLMIFSGTWRAFIRPKKHSLN
>NC_009831.1|WP_190273173.1|4588363_4591249_-|flavodoxin-domain-containing-protein
MKKNLGPHLEKLWLLFAWSTLILAFIIGHIAAKPDYLTMAKSHFSNFNLVPSKDYTSLPVVFVPGEDSQSSISGGEAVVIAAGTGYGGPFVLGVRAQKGENSARIKEVVVLSHKETPAYLQKLINNNFFRQFINKSVTDNFLLEEDVDGISGATVSSKGFTKAIGLALHQGAQSHLGYEKTWHEVEWSPGLNEALMVALFLMVLVVVYAPRQIAKPFKLILPFASLAFVGFYVNASISLGTLAGIAMGYVPEFRQYPIWWIIVGGVLGGILLLGRNLYCGYLCPFSVIQDLLQKVSGIKLALRPGMARNARRVIYGLSWLALILIFLSRHPALGSYEPFGMMFSLQGMGIQWYILPFSLLGSFFVPQFWCRLFCPVGLYLSEAVRLQHATVRTVGNILVKNVTGRPSDSKIIADSYSKATDTLTILFASQTGNSKHLAYQLKASCDANSLPVRIASMADYDTDNLQRESHLIIVTSTYGEGEPPESAEGFYHTLFADNAPQLPDLSYSILALGDTSYRFFCKTGIDFDERLSELGAQRLHERAECDVDYDAMADTWITSVIKVLQNRLEASCANAVMPIESTGAEQAYYNKARPFSARLLCNDRLAPDACEKDFRHIALSLEGSGIQYQPGDLLSVWFKNDETEVATLLANLSIPADVEVEVDGNIRTISQALIENYELTQCHPAFIEKYATLSQQAELLGLVADFDGVRDYARRHQIFELVRLYPARLTAEQLLSSLRRLTPRKYSISSSQSDVGEEVHLTIAVVEYMSGQGVESHRYVGGASGYLCQRLALNAEVNIFVEENEHFRLPEHGDASMIMIGPGTGVAPFRAFMQQRAAQKHTGKSWLFFGNRNEELDYLYRDEWQQHLDSGVLTRMDLAFSRDQQQKIYVQHRIEQQGAEFYGWLEQGAYIYICGDVSHMAVDVEKAILQVIELHGEMSCDEALKYYERLKHEKRLLKDVY
>NC_009831.1|WP_150104367.1|4588083_4588290_-|hypothetical-protein
MSQSNNTGHEQSGNKGSTFETKMSFGLGMITLLLIFGYFYESFQEIQRQEIIVIAIDRIEAASDAKKD
>NC_009831.1|WP_012144099.1|4587334_4587988_+|DUF1707-domain-containing-protein
MDVILEDRPIEQIREEVIDQLIVNYSHGVISAEAFERRLDDAMNSSSHREILDLVADLSLKADTDYSNKKEHQFTPSYSNKTEDDQLSLNCILGNNERSGQWQVPKVINVRNILGESTLDFSDAIFQHQHVTIKLNCVLGGAIIYVPEGINVVCKTYGIVSSIENRAPSLANRQAPVITIEGKVVLGSLNVSIKRTIKEKFIEFANNLKSAFDMKAR
>NC_009831.1|WP_012144098.1|4586598_4586964_-|response-regulator
MDKSKILIIDDDPVCTGVLLAILGDDYDVTTANSGSGGIDILSSQTPDLILLDITMPEVNGYQVLKFLQEDPSRIDIPVVVISTLVESSDQEFAIKLGADDYVNKPIMPNVIQEKLEKYLR
>NC_009831.1|WP_012144097.1|4585577_4586237_-|hypothetical-protein
MKAVELAKAILVSTSLMMIAPATMAEPPTNTEKKAENKAEKKAMKEQKKSEKEARKAAEKREREARKDAKEYDREARKDAEERQREARKYDKEYDREARKDVEERQREARKDAKEYDREARKDAEERQREARKYDKEYDREARKDVEERQREARKDAKEYDREARKDAEERELEVRKDAKERQREARLEAEERQREAKEKAKERESRDCKKNEECEEFL
>NC_009831.1|WP_041422341.1|4597643_4598702_+|MBL-fold-metallo-hydrolase
MIFHRIRTERGCQSYLIGCSETNSAIIIDPEISQMEHYLGLASHDGLAIHYLLDTHTHADHFSASKQLASQLKVPVIMHCNSPAPFVDMYVDDGEIIIVGKLRLTIMHTPGHTADSICIVMKDRVFTGDTLLLGGTGRTDLPSGDPERLYDSLFNGLLKLSADLKVYPAHAYSERTHSSIGEELSNNPRLQKKDRDEFVAQMRAIDLKMPTQLTESLRTNLSGGKTVEQFISDAERKISFVSLEQVLRYSQSIAPKFVIVDVRERDAFDKGHIAGAIHIPRGQLELRVNELLPDPTRRIAVYCEFGIISVLATSTLREMGFLRAVALDHGLNLWRELGYPLIESKNEEGNEQ
>NC_009831.1|WP_012144108.1|4598892_4599150_+|ribosome-alternative-rescue-factor-ArfA
MAKHRKSSSHIEHDSKRGKIKDNALKALVTSELFKMRTERPKKGKGSYNRKQQKGHKLKGFAPFDFSAFNFHLFDFSPLFLIKLS
>NC_009831.1|WP_012144109.1|4599631_4600567_+|DMT-family-transporter
MQNPVPLPKMVPFAFLSVVLIWSTTPLGIVWSSASVHPTMAVLLRMVLALVLGSLLLVIFQIRFPWTKAAKKLYGFSSIGIVGGMLLSYFAARYLASGTMSLIFGLSPLISGILAQKLLNEPKFGPTKLLALAMAFIGLGIVCSSKLSLNSDSWIGLLLVLAAVSLFSLSGVLIKTVKINIHPIASTVGALLFSTPLFTLAWLLFDGTLPVDTWQVKSIWAIIYLGVFGSLIGFIAYFYVLQNLKASTVALVTLITPVFAMTLGATLNGEVITDTLIIGALFVIGGLALYQFGEKLQSLLKTIRGRRHIKR
>NC_009831.1|WP_041421820.1|4600868_4602197_-|diguanylate-cyclase
MKVTLRLKILLIVSLMLTSIILISFITLKEIQMQTNSQLYQVSDIEHKIDLLSSKLWLLQQYHDEDALVQTRDAHEELKLLLNKKLFTHKNKIIIVANLIRMNANLGTLLELSQKDLESQFRHGITSPAGMLSARYSMTLQSMNEDLGKLERLAIKDSEISQRKILFAVILLMVVGSAVVMALTLFTLKTFNTNLNALTVGIKDLAKGNLNSRIEIHDTDELSILAEQFNLMKRSLEETTIKKDQLQLEVDRQTKELQQQREEFQHQANHDSLTKLYSRSAFEEQMKTAIARCGRTKQSAALLFIDLDRFKAINDCHGHAAGDAVLIQIAQKLLQTVRSSDIIARIGGDEFIIWLEPIENATQVITVINKLIEEFALPMQYQDVELLIDASIGVGFFPIDATELSGLLKVADDNMYKAKEIDGTTFQLTNKATVGFSDAKMA
>NC_009831.1|WP_012144111.1|4602284_4603280_-|ABC-transporter-substrate-binding-protein
MIKKLLLFLAFVGVATYLIVGVQTETSNEAFTAPIKIAMSTTPLSSPLIIAQELSLFDKHKVHVELLPVRGGHRSFTMMSNGEVDLATSSESVVMFNSFLRTDFSVLASFVESDNDLKLITLKSSSITEAKLLQGKNVGMVESSASEFFIYAYMILTGNKEVKFNRVFMDASELGPALLSGRVDAISIWEPLGYQLNKEYGDQISQFQTRGIYNLSFNLIAKKATLENSLNSYVRILAAIDEAQNYIAENPKRSKSIVSDFLHIPVTELEWGWTDYLFRLSLSNVLLSNLQTQARWAIATGSVVDTKGMPDFRQLIDTRALERAGNIETDL
>NC_009831.1|WP_083758983.1|4603410_4605180_-|HD-domain-containing-protein
MLANSLYINVEQAKQQALVQAAIEVGTNLAQHDLTTVMSHLEFLTASENVESYLDNGIDDSKAHIEREFLNLANTSQLYDQIRLISPSGIELVRIDYFDEQAVAVVPELLQDKSNRYYFQEAAAITTDKMYISALDLNVENGVIEQPLKPMIRFAKPLKDENGELRGVIVLNYFANLLLDKFRNQMMFAPGEGALLNKDGYWLSSRDPSQEWGFMLDHKLSFGTDSPELWQTISLAEKGSVENSDGLVTFATVHPIKDIDKKVANRDHFIDEWRIIIVNTYWGLGPALVLSKIEFLYPALIIYPIGLILLWFWARASVGRKCAERELKKLNKTLTLRVAERTKELAVIKDVTILSMATLAETRDNETGQHLRRTQTYVKLLAEELQDHPDFHDFLSDKNIDLLYKSAPLHDIGKVGIPDDILLKPAKLTDFEFEIMKRHTTYGSNAISSSIHTLTSELAENDGPTFLQFAQDIAHYHHEKWDGRGYPNGLSGDDIPIAARIMAIADVFDALSCKRVYKGAFSRDKTESIMLEGRGTHFDPRMIDAFCRVNDSFWEVKALFEDEPPEVTNGCIEHFPVEYSQLINFGQGI
>NC_009831.1|WP_012144113.1|4605632_4606121_-|hypothetical-protein
MPSSLVKLAVTTCTLLAIGSGIGISAYLNSGHSENHDHLLPLVIGSWVKIPGFCEGKTVYLDQMDIVNKQSMIMKGETLEIVNFQLTNTSPINLTCEPIGEVELFAQTSFIADKFSRFYVGKVSGYTVMKEVSPTGDLWFKLDIRLQKKLQAMNKMNNRARI
>NC_009831.1|WP_041421821.1|4606493_4606697_-|hypothetical-protein
MSYTAPMPKQLNFTVNQHLYQTSNHYRCRVDYVIKLLGSKEMAANHQSLNYRADIINEEKDFVLGYN
>NC_009831.1|WP_012144114.1|4607040_4607952_-|hypothetical-protein
MLDAICMFDEDEPVTYSVFKFQKLSDADIERYRQSLICPQCHGKAYYRKASLDGKAACFGSRYHQANCKEFKPSQAKAREEQDAIEVNQLVVDSDALIIDFTKRPSIHAPKAGAKPVSKEKSLQAESGPNVGEEREVVDSYKVDVESAKDDISKTSLPDDKRVSTQGLEKLLHSLLRGSELAESELWVYTDDKYRWRAKNLFVNFADAEPTENGAPRMYWGTVSHIDKSMQWLNPSDSRDVGIPIEEFQGSLFERFNIKDRRDIEGAGIILFGKCFLNKDKTRKIIQLWGKDISRVFISKLDD
>NC_009831.1|WP_049772182.1|4607973_4609050_-|endonuclease/exonuclease/phosphatase-family-protein
MQSQSTNGSDASELIKIATFNLFNFIEPPGAFYEFENIYTQEQWQKKLDWIATYINEHQPDVIGFQEVFTPDALAQLTQRCGLEYFAVLDTPEVVDDFIYSKPVVALASRYPITEVHNVTVGDGWASMMGLQDDFGFSRKPLRVTISLPKLGSCDCYVVHFKSKRPLFDAQELNGLTTPSADSSGGNVGQLLSIEALAQWGSSIQRGCEAALLRYSMVERRTQTGNPMVLMGDFNDILSDGVLASLTSVDTRIKPDPLLGEVEHQLRDHRLKDAYELYQSSQYSLSCQQRPATHYYFAKGSVLDYILLSSEFDIKNSRSLAEVGRYETYDRHLINPRFERDSQSTDHAPVMITISIRH

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Crispr_ID: NC_009831_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009831_9

4627929-4628030

Orphan

Consensus_repeat	Method
TTCGCGGCTAAAGCCACTCCTACAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_009831_9

>merge|NC_009831|9|4627929-4628030|CRISPRCasFinder
TTCGCGGCTAAAGCCACTCCTACATGGGGAATGTCGAACCTCGTGGCTAGAACCTAGAACCTCGTAGCCCCAAAACATTCGCGGCTAAAGCCGCTCCTACAT

>NC_009831|9|9|4627929-4628030|CRISPRCasFinder
TTCGCGGCTAAAGCCACTCCTACAT	GGGGAATGTCGAACCTCGTGGCTAGAACCTAGAACCTCGTAGCCCCAAAACA
TTCGCGGCTAAAGCCGCTCCTACAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_009831.1\|WP_041421825.1\|4618985_4619507_-\|menaquinone-dependent-protoporphyrinogen-IX-dehydrogenase	unknown	unknown	gnl\|CDD\|182966
NC_009831.1\|WP_012144130.1\|4626960_4627794_+\|TIGR03899-family-protein	unknown	unknown	gnl\|CDD\|274842
NC_009831.1\|WP_041421823.1\|4616473_4617136_+\|thiol:disulfide-interchange-protein-DsbA/DsbL	unknown	unknown	gnl\|CDD\|239317
NC_009831.1\|WP_012144133.1\|4631285_4631633_+\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012144129.1\|4625709_4626900_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NC_009831.1\|WP_012144138.1\|4634238_4635987_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012144137.1\|4633740_4634154_-\|DUF3010-family-protein	unknown	unknown	gnl\|CDD\|378599
NC_009831.1\|WP_012144122.1\|4617224_4618274_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340839
NC_009831.1\|WP_012144139.1\|4636909_4637677_-\|phosphoadenylyl-sulfate-reductase	unknown	unknown	gnl\|CDD\|234997
NC_009831.1\|WP_012144127.1\|4622731_4624129_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378583
NC_009831.1\|WP_041421827.1\|4631736_4632117_+\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012144136.1\|4632759_4633614_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224632
NC_009831.1\|WP_012144135.1\|4632180_4632708_+\|redoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|224146
NC_009831.1\|WP_012144132.1\|4629599_4631144_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|143479
NC_009831.1\|WP_012144123.1\|4618350_4618887_-\|cytochrome-b/b6-domain-containing-protein	unknown	unknown	unknown
NC_009831.1\|WP_012144126.1\|4621515_4622670_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271141
NC_009831.1\|WP_041422345.1\|4619748_4621362_-\|c-type-cytochrome	unknown	unknown	gnl\|CDD\|368963
NC_009831.1\|WP_041422349.1\|4637669_4639379_-\|assimilatory-sulfite-reductase-(NADPH)-hemoprotein-subunit	unknown	unknown	gnl\|CDD\|237402
NC_009831.1\|WP_012144128.1\|4624606_4625467_-\|formylglycine-generating-enzyme-family-protein	unknown	unknown	gnl\|CDD\|224182
NC_009831.1\|WP_012144131.1\|4628119_4628929_-\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|381169

Protein	Function_ID	Function_description	E-value
NC_009831.1\|WP_041421825.1\|4618985_4619507_-\|menaquinone-dependent-protoporphyrinogen-IX-dehydrogenase	gnl\|CDD\|182966	PRK11104, hemG, menaquinone-dependent protoporphyrinogen IX dehydrogenase.	1.80134e-62
NC_009831.1\|WP_012144130.1\|4626960_4627794_+\|TIGR03899-family-protein	gnl\|CDD\|274842	TIGR03899, hypothetical_protein, TIGR03899 family protein. Members of this protein family are conserved hypothetical proteins with a limited species distribution within the Gammaproteobacteria. It is common in the genera Vibrio and Shewanella, and in this resembles the C-terminal domain and putative protein sorting motif TIGR03501. This model, but design, does not extend to all homologs,but rather represents a particular clade.	3.51633e-143
NC_009831.1\|WP_041421823.1\|4616473_4617136_+\|thiol:disulfide-interchange-protein-DsbA/DsbL	gnl\|CDD\|239317	cd03019, DsbA_DsbA, DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol oxidant known, due to the unusual stability of the thiolate anion form of the first cysteine in the CXXC motif. The highly unstable oxidized form of DsbA directly donates disulfide bonds to reduced proteins secreted into the bacterial periplasm. This rapid and unidirectional process helps to catalyze the folding of newly-synthesized polypeptides. To regain catalytic activity, reduced DsbA is then reoxidized by the membrane protein DsbB, which generates its disulfides from oxidized quinones, which in turn are reoxidized by the electron transport chain.	9.2936e-45
NC_009831.1\|WP_012144129.1\|4625709_4626900_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.1459e-12
NC_009831.1\|WP_012144137.1\|4633740_4634154_-\|DUF3010-family-protein	gnl\|CDD\|378599	pfam11215, DUF3010, Protein of unknown function (DUF3010). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	1.70242e-36
NC_009831.1\|WP_012144122.1\|4617224_4618274_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340839	cd03811, GT4_GT28_WabH-like, family 4 and family 28 glycosyltransferases similar to Klebsiella WabH. This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.	9.25223e-37
NC_009831.1\|WP_012144139.1\|4636909_4637677_-\|phosphoadenylyl-sulfate-reductase	gnl\|CDD\|234997	PRK02090, PRK02090, phosphoadenylyl-sulfate reductase.	1.29905e-131
NC_009831.1\|WP_012144127.1\|4622731_4624129_-\|hypothetical-protein	gnl\|CDD\|378583	pfam11180, DUF2968, Protein of unknown function (DUF2968). This family of proteins has no known function.	0.000184255
NC_009831.1\|WP_012144136.1\|4632759_4633614_-\|hypothetical-protein	gnl\|CDD\|224632	COG1718, RIO1, Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning].	4.90631e-68
NC_009831.1\|WP_012144135.1\|4632180_4632708_+\|redoxin-domain-containing-protein	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	3.17596e-37
NC_009831.1\|WP_012144132.1\|4629599_4631144_+\|hypothetical-protein	gnl\|CDD\|143479	cd07563, Peptidase_S41_IRBP, Interphotoreceptor retinoid-binding protein; serine protease family S41. Interphotoreceptor retinoid-binding protein (IRBP) is a homolog of the S41 protease, C-terminal processing peptidase (CTPase) family. It is thought to facilitate the compartmentalization of the visual cycle that requires poorly soluble and potentially toxic retinoids to cross the aqueous subretinal space between the photoreceptors and the retinal pigment epithelium (RPE). IRBP is secreted by photoreceptors into the interphotoreceptor matrix (IPM) where it is rapidly turned over by a combination of RPE and photoreceptor endocytosis. It is the most abundant soluble protein component of the IPM, consisting of homologous modules, each repeat structure arising through the duplication (as in teleost IRBP) or quadruplication (in tetrapods) of an ancient gene, arisen in the early evolution of the vertebrate eye. IRBP has been shown to promote the release of all-trans retinol from photoreceptors and facilitates its delivery to the RPE. Conversely, IRBP can promote the release of 11-cis-retinal from the RPE, prevent its isomerization in the subretinal space, and transfer it to photoreceptors. In vivo evidence implicates IRBP as a retinoid transporter in the visual cycle, suggesting a critical role for IRBP in cone function essential for human vision. IRBP is a dominant autoimmune antigen in the eye; IRBP proteolysis analysis has proven a useful biomarker for autoimmune uveitis (AU) disorders, a major cause of blindness. This family also includes a chlamydia-secreted protein, designated chlamydia protease-like activity factor (CPAF), known to degrade host proteins, enabling Chlamydia to evade host defenses and replicate.	1.174e-09
NC_009831.1\|WP_012144126.1\|4621515_4622670_-\|hypothetical-protein	gnl\|CDD\|271141	cd14658, Imelysin-like_IrpA, Imelysin-like domain in iron-regulated protein A. This family includes putative iron-regulated protein A (IrpA) mainly from Bacteriodes, proteobacteria and cyanobacteria, with domain similar to insulin-cleaving membrane protease (imelysin, ICMP) protein. It has been shown to be essential for growth under iron-deficient conditions in the cyanobacteria Synechococcus sp. The conserved GxHxxE motif is similar to other known imelysin-like proteins that are regulated by iron, such as ICMP, IrpA and EfeO. Imelysin is a membrane protein with the active site outside the cell envelope. The tertiary structure shows a fold consisting of two domains, each of which consists of a bundle of four helices that are similar to each other, implying an ancient gene duplication and fusion event.	6.46028e-104
NC_009831.1\|WP_041422345.1\|4619748_4621362_-\|c-type-cytochrome	gnl\|CDD\|368963	pfam06537, DHOR, Di-haem oxidoreductase, putative peroxidase. DHOR is a family of di-haem oxidoredictases. It carries the two characteristic Cys-X-Y-Cys-His haem-binding motifs. The C-terminal high-potential site functions as an electron transfer centre, and the N-terminal low-potential site corresponds to the peroxidatic centre. Its probable function is as a peroxidase.	0
NC_009831.1\|WP_041422349.1\|4637669_4639379_-\|assimilatory-sulfite-reductase-(NADPH)-hemoprotein-subunit	gnl\|CDD\|237402	PRK13504, PRK13504, NADPH-dependent assimilatory sulfite reductase hemoprotein subunit.	0
NC_009831.1\|WP_012144128.1\|4624606_4625467_-\|formylglycine-generating-enzyme-family-protein	gnl\|CDD\|224182	COG1262, COG1262, Uncharacterized conserved protein [Function unknown].	9.73298e-47
NC_009831.1\|WP_012144131.1\|4628119_4628929_-\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|381169	cd11642, SUMT, Uroporphyrin-III C-methyltransferase (also known as S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT). SUMT is an enzyme of the cobalamin and siroheme biosynthetic pathway. It catalyzes the first of three steps leading to the formation of siroheme from uroporphyrinogen III; it transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. Precorrin-2 is also a precursor for the biosynthesis of vitamin B12, coenzyme F430, siroheme and heme d1. This family includes proteins in which the SUMT domain is fused to other functional domains, such as to a uroporphyrinogen-III synthase domain to form bifunctional uroporphyrinogen-III methylase/uroporphyrinogen-III synthase, or to a dual function dehydrogenase-chelatase domain, as in the case of the multifunctional S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase/dehydrogenase/ferrochelatase CysG, which catalyzes all three steps that transform uroporphyrinogen III into siroheme.	2.44144e-124

>NC_009831.1|WP_012144130.1|4626960_4627794_+|TIGR03899-family-protein
MVELARINETKAAQSDVSARKKALLLGRQLGLSSEEGYRPGNASVAERAAFRQQKVSSQYQANLETIYAIALSNTPSDVTGVDLDPDWAHQFFQIAEQIHNRKMQELWGRILANEITTPGNFSLRTLSTLKQLTHKEAQIFEKALGMAVKVNNESRLKLIIGYRYTGGFGQIFRKSSPINIGLSNFGLPYSNILTLVDAGILHRGEFETGLLNSKTPMSFTLLDEKMKLTPKSGHLLFNYYRLTPIGDELTQLIHPKADTEYAKAFKTLFSKDFKIE
>NC_009831.1|WP_012144129.1|4625709_4626900_+|MFS-transporter
MSKSPQKLLLWMTFIMSLVFSVWQVLLNNFVIEQAQFTGAEIGVLQSLREVPGFLAFTAIFILLLIREQAFALLSLALLCVGVAITGFFPQVLGLYLTTILMSVGFHYFETINQSLTLQWVDKKETAGFLGKALAWRSAAALSGYASIWLIMSWLKLDYVWMYALIGCLGLLMVITITVYFPQFEVGEPQHKKVILRKKYWLYYLLTFFSGARRQIFMVFAGFMMVEKFGYSVSEITTLFLINYVINLLFAPAIGRFIGRIGERRALTIEYLGLIIIFVSYALVEHPEMAAALYVIDHLLFAMAIAIKTYFQKIADSKDIAATMSVSFTINHIAAVVIPAMLGLLWLYSPQAVFYIGAGFAACSLLLARNIPTMPTQGNEVNWSWSPKKTAHRVKQ
>NC_009831.1|WP_012144128.1|4624606_4625467_-|formylglycine-generating-enzyme-family-protein
MSGLKLSHLPLPGLSRLIVSQLSLLPLLMSSSVLADSTQLKVGVLVPESSFQMGCSVKDSDCESDEGKPGGVSVFVPAFYIDTHEVMVSEYQACLDAGKCQRPKDHDRNQYCNLGAKGRDHHPINCVDWSQAQAFCQWRGQRLPYEAEWEKAARASSLTRYPWGDAVSCKQAILDDGKTMGSVAGEPDGCGEDRTWPIGSRSANALGLFDMHGNVGEWTMNWYAKDGIAQYVQGNLTDQKPTPRKVVRGGSWDETALNLRSSFRNIKAPISGDSIYGSIGFRCAND
>NC_009831.1|WP_012144127.1|4622731_4624129_-|hypothetical-protein
MKSKLTLLALSITTLSLAGLSSTQVLAAEPEQLQQAIAKQEAELNKLKRDLAELASQQKLQQQEQQKQAQVVTAAKQELADSKFSKFKFKSYGSMNYTSAEYFENVQDTSPERRGRFDLERIVTEFGYQFNDEWDMEVEIEYEHGGTGTALEYDGFDEFGEFESEVEAGGEVMIEKAQLRYRPSDAFGVKFGNIHLPIGLSSILHKPDQYLTVLRHRSEAAMLPAVWNETGVGLFGEVANFHYQAQVVSGLNSEYFRTYDWVASGHQKRFEHVNADDLAYALRLDYGNFKKGSAVGVAYYYGNTTGNRHKSNKVSGDGTVSILAVSGAFVQGPWILRGQYLNGTLSDADAITQSNKTTPGLKPGNFAQLGSKSEAFFVEAGVDLGQFTPVPITIFANIDYSNPLAEVETGTATKRYENTWTSVGVNYFPIPEIVLKAEVGRQQVAVSSIPDTNFFALGVGYQFSL
>NC_009831.1|WP_012144126.1|4621515_4622670_-|hypothetical-protein
MKSLKYSAIAIALALISTLAACGGSGSDDTTPPVDESKFEFAATEMITNLTDDVIVSGYATLAMKGESLLLATQTLVNTPTQANLLAAQEAWKAARQPWEQGESHIFGPVDSLGIDPHLDSWPLNTTDLTTVLANNSGFDAETIKGWNDDVQGFHTMEYLLFGDGIADNEKAIADLTTAENEYLMGLAEVFRDYTKVLDDAWQVSHDGQSGKAYGELVKSPGSDGNTFYSSQVGVIQELVNGMIGIVDEVGNGKIADPFGVSLETADTSKVESQYSWNSLTDFSDNIVGVRNVYQGELTGASDKQGIVDFVKAADATLAARVGSEIDDAIIKIQAISGTNNMPFRQAISDVEGRARVQTAIDALSKLQTSLESDILPLLNDWKV
>NC_009831.1|WP_041422345.1|4619748_4621362_-|c-type-cytochrome
MTHRYPGLAFALCIGLSACGGSGDDTPEPKPDEKIYPAYTDISASGGETTTFDASESGHGFSTPAPNLSDANLELHLEGDLGFETAFTTAPNSEHPDLDGLGPVFNNADCNSCHQRDGRNSTPMVQVGKDRIKLGSEAGLFLRISKAPAEPCTLGTEANNYCAPIGVPNFGGQLFHRGVLKARPDWEDNLFGGQADVYLSYETKQVTYPDGTSITLKKPLFDVENPYDAPGETLSSANVTSELLQDDVLMGWRNGMPVFGLGLLEAIPEADILALVDIDDVDGDKISGRANFVFDAVKAQAGDPNPVSLGRFGWKANTPSVRVQSLGALRGDIGITNPLFPDESVVGTALHDSYLTRTGFTDTGEDENGAPEASAEFSDSVVFYAETLAVPARRNIESQDVREGARLFEQLNCTGCHKARFVTKSAGNIGGLPMAEALKGQTIYPFTDMLLHDMGDDLADGRPDFLADGNEWRTRSLWGIGLTQTVNPQAGFLHDGRAATLEEAILWHGGESEQSRDDFMALNRSEREQVVDFLMSL
>NC_009831.1|WP_041421825.1|4618985_4619507_-|menaquinone-dependent-protoporphyrinogen-IX-dehydrogenase
MSNILIIYSSVHGQTRKICEYLEQQLEAVGNTVTASSIDDVPDLAVFDKVILGASIRNGKHNPSVYEFISHNRVMLEQKVTSFFSVNLVARKPAKNTVETNPYTKAFLEKTDWRPTLLKVVAGNIDYQGYGAMDRNIIRFIMWITKGPTDANTKIEYTDWAKVETYAQEFHAL
>NC_009831.1|WP_012144123.1|4618350_4618887_-|cytochrome-b/b6-domain-containing-protein
MSKPASAITKLFAKLNELQHLFIIILSAYLIITSGWILIGRSLRASASFWDLAHVYLGLITAIFSFTFLLSNSLKGKWRQYFPWLKGDFSQLKKDISGLFKGKLPIAGGSGLFSWIEGLGMLVFVGVGFTGVIWYFLQGTPDALLWRGYHIMLAKSFIGFIVLHIVLAGLHLLDFIRD
>NC_009831.1|WP_012144122.1|4617224_4618274_-|glycosyltransferase-family-4-protein
MRPQVIHLVDDSKLGGVKLALESQSESSLKQTFDFKICILNLHSWFPRRYSADIICLHAAASWRKLPGLCLLRLANIGTPLLYQEHHYSEYFVKHRVAKSWRFLLMLRLCYRLMTRVLSVSDAQANWMKRERLTSQDKLIVMGQAKDVTPFLMLSAKPIGRPVVLGAYGRFDSQKGFDLLLEAMTQLSPEKVELRLAGGGEELEELETKWANLPHVRFVGEVHDVPQFLSGCDAVVIPSRWEPFGLTCQESLTAGKTIITSGVDGLNEQLEEIESLGLNRTGDLIRLAELTPEKIVEAIDKLIDRAEALLGDNKESNASLGLSRQARQIVAARWPVLLEKWREVLSKHL
>NC_009831.1|WP_041421823.1|4616473_4617136_+|thiol:disulfide-interchange-protein-DsbA/DsbL
MIKHIALALTLAVAPLSSFAAQFVEGKHFTQVSDKAPSAQPKLTEFYSFYCHNCFNMETQYLGDIKANLNKNVKFDSKHVDFMNSEIGTEVMRSLAVIQELDAGDKMTHAMFAAIQGDEGANGHSHDHDHSAHEKPELNNRDDIKKVFADKGFDVSKYDAIADSKAVNDKIDLWRVQQREFRIQSVPAFIVNDKYAVNMGQVRTLGELIDLINYLAVEHK
>NC_009831.1|WP_012144131.1|4628119_4628929_-|uroporphyrinogen-III-C-methyltransferase
MEIVTLPGQRAGGKVWLVGAGPGDVELLTLKAYRILKSAEVVLYDALVSEDIMALVPFDAEKIAVGKRAGKHSANQDEINQLLVTKGFTRKNVVRLKGGDPFIFGRGGEELQSLVEAGLEFEVVPGITAASGTSSYAGIPLTHRDHAQGVTFITGHCQLGSRPMDWANYANPSNTLVIYMGILNAGIISQGLIDAGRSAQTPVAIVSKATTSEQRRFIGKLGELEQLAADPELKMPALMIIGEVVQLADTLNWFTPQSDSESRPISYEL
>NC_009831.1|WP_012144132.1|4629599_4631144_+|hypothetical-protein
MRFGFKEIVNTFGLCLLISTLQLAHLTLTSTEYRVSLRHGEMRHDLNILVDELRQHSAFSGLNSSRLENIEQAIDSILYRYPINITSDKFKAEVIKLIAMLDDPGTSITTHTQASGVLPLRLRPLGDTWLALNEDEQLLDPQHPYITHIDGIPLSRWIDVSLRFIPYSLRLSLSQQIQWLSQLNMLRAEMGLAVTNKVRLTLTDNLDSNIQLILAVQTDSPLKDALILKDPLDIESGAALISITDLTRFETDPLALKELQLAFTHPLTILDLREVTGNSDRLLRLLVSEFAGTEQFNRSDEADRYLMALSQYRRSTDFNGNLLRPLNFLPFDEFNFFEQLQFSDISQTINNENAARFGHWYARRSPAITGLNTDESKAHRLALLIGPECREECEWIAYVAKSLPRVTLIGEKTSGDLGKRYGFRLPQSNIEVRVTASITYSARGKLLSGIGTQPDIELPINETIHWQGLVTLLTHERGPGENNQASVPELSLKRVETADSKNSALIDLWSQSSP
>NC_009831.1|WP_012144133.1|4631285_4631633_+|hypothetical-protein
MSNKAKHLLTADTFNRGALRMTVALLRGVNPRLALTIQNQMSGPLNPQSDACPSPKDNFRLTLKPIEVRLVVETLKAKGEHPNADPGTEMLIKALIIDWVNYANYLIELENEHDA
>NC_009831.1|WP_041421827.1|4631736_4632117_+|hypothetical-protein
MSSPIGGFYLNAQYRKKAEKFELSSKPKLNISIELQLDGGIILNDSQIGLADIECRFSSSQAAISLHPTVTTTGMIRLDCSIKIEHQDDDIAQTKQQLVNIESSETLSTLVEGNERIRLKISCNIC
>NC_009831.1|WP_012144135.1|4632180_4632708_+|redoxin-domain-containing-protein
MIKLTKILIVSLILTCSAYVQASDLKVGDKAPDFKLQSTNGEFYQLKDYLGKQTLVLAWYPMANTRGCTLECRSLVQKGHLIREYNAAYMMASVDDLEDNQDFAKKQKADFPMLSDPTKETAKAYDVLNFVRVASRVTFYIGEDGTILKIDEDINAETAAEDIAATLKQLGIEKQ
>NC_009831.1|WP_012144136.1|4632759_4633614_-|hypothetical-protein
MKIPKRIQPLVDEGLVDEVLRPLMSGKEADVFVVRSGNEVRCAKIYKEAEKRSFKQAVQYREGRKGRNSRRARAMEKGSKFGRNEQEQAWQNAEVDALFRLAYAGVRVPQPYGCFDGVLLMELITDEQGFVAPRLNDVTLTAEQALAHHKVVMKDVQRMLCAGLIHGDLSEFNVLLDSCGPVIIDLPQAVDAAANNNAKRMLERDVNNMTQYYGQFAPELLKTKYAKEMWALFESGKLNPDSELTGKFKESTKAADVDSVLAEIEAAFDEEQERKERIREAVEG
>NC_009831.1|WP_012144137.1|4633740_4634154_-|DUF3010-family-protein
MLVAGMFLKANEVRIVTLKGTRATHELVAPKTNKFTLIKNPTQGEVVTFGEQVKAFCIEHSIDKLVLNRRASKGQGAGGAGTFLMEGVILALSPSNIELVHPATVRATDKRTSEFKALKPKTVDLGKAYDLAFELLT
>NC_009831.1|WP_012144138.1|4634238_4635987_-|hypothetical-protein
MKKILIAAAVVAAGAGGYWLSQDKPSSVSSQSDTVLASVPADTPLFSGQLKPFPIKSYVNSLSQSYKTAPAELFAELEQSDDARAKFLLSLSRSYMDSLQSGEQFIATFGLSEKIRSYFYTLGILPVVKFEVEKPQAIWTLLDKAELDSGYSHEIRTLKGQEYRVYTLSDIGEPDKLELLIAQKDGLLTVTLNSAFIDEPTLETALGVRPVAQSLADSGIIEQIIKTHGFSDEAIGYLNHQEIVKAITTKEGNQLAQQITAFSAQEGEDLLAEFRTPECHKEFSAITANWPRTVFGVNSVNIVDKQSSFDISTIVESKNQTLLNAFKKMRGFIPDYAKNPGDSVFSMGVGIELNQLVPSLTAVWDELLQPQYQCQVLQEFQQELSGQSPAMLGMFTGMANGVRGVSAALIDYKFTESSASEQGEPRLESIDAIVSLSADNPSMLFNMVKPFAPELANIQLPQDGSVIDLSHLLPLPPEYGIQPKMAVKGSHLVLFNGDKAEAIAEQLAAEPLTDNGLYNIALDYKKLFTPIVTLAEMTGEPLPEELSMMKDYDMQVKMGVDINEQGIVFDSYINNKVTPAEE
>NC_009831.1|WP_012144139.1|4636909_4637677_-|phosphoadenylyl-sulfate-reductase
MTNSIKVESIVSADELLALLSAPQVEQKLELERINQFLAELNPAQRVSWGLDYLPGNHALSSSFGIQGAVMLHLVSAQKADIPVILTDTGYLFSETYRFIDELTERLKLNLKVFASPQTPAWQEARFGLLWEKGLDGLDQYNRMNKVEPMQRALGELEVGTWFAGLRRSQSSTREALPILAIHGSRYKILPILEWSNKDVHEYLTEHYLPYHPLWEKGYVSVGDVHSSKPLELGMSEEETRFNGLKRECGLHFDI
>NC_009831.1|WP_041422349.1|4637669_4639379_-|assimilatory-sulfite-reductase-(NADPH)-hemoprotein-subunit
MTVENVEEKLSINEHLKTDSDFLRGGIEEGLDTAVTGAFSEGDQQLIKFHGFYQQDDRDLRNERKEQKLEPLYSFMLRARVAGGVCTPEQWLGVDEISSTLTSSNSIRLTTRQTFQYHGISKRNLRTLIQSLDKKALDSIAACGDVNRNVMCNPNPVESRLHEQAYYWAKKLSDIYLPRTKAYAEIWLGDDKVATSEGDEVEPIYGKTYLPRKFKMAVAVPPDNDVDVYTNDLGLIAVAQEGELVGFNLVAGGGMGSTHGEVETFPRLADDFGFIKAEDTLKFAEAILKVQRDWGNRSNRKQSRLKYTIVKHGYDAFKAEVEKRAGVTFEPKRDVVIGDRGDRYGWIKGVDNRWHLTLFIEGGRIKDLPGQPLQTGLREIAKIHKGDFRMTSNQNFIVAGVAEEDKEAIEALARNHGLMGKLITETRGRSIACVALPTCALAMAEAERYFPDFLTKVESLQEKHGFADQGIVIRMTGCPNGCARPFAAEIGLVGKAPGRYNLYLGASFEGTRLNKLYRENIQEAEILSELDQLFARYVSEREEGETFGNFTVRSGVVKAVIDAAKDFHD

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Crispr_ID: NC_009831_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_009831_10

5193725-5193953

Orphan

Consensus_repeat	Method
ACCCAACCTCTAGACCAACCACCAGCCATTCTACCTCCTACTC	PILER-CR

2 spacers

The CRISPR arrays of NC_009831_10

>merge|NC_009831|10|5193725-5193953|PILER-CR
CTTTAGACCAACCACCAGCCATCAAACTCTCCTATGAAGCATCCATCGATTTGATCTTGCACCATCATCCAACCCCAACCTCTAGACCAACCACCAGCCATTCTTCCTCCTACTCTTTATTACCTATCTTTTACTGTCTAGTGCCTGCAGTATTAAAAACGACGATATACTCAACCTTGCACCTTCACCCAGCCACTAGACCAACCACCAGCTATTCTACCTTCTGCTC

>NC_009831|10|1|5193725-5193953|PILER-CR
CTTTAGACCAACCACCAGCCATCAAACTCTCCTATGAAGCATCCATCGAT	TTGATCTTGCACCATCATCCAACCCCAACCTCTAGACCAACCAC
CAGCCATTCTTCCTCCTACTCTTTATTACCTATCTTTTACTGTCTAGTGC	CTGCAGTATTAAAAACGACGATATACTCAACCTTGCACCTTCACCCAGCCACTAGACCAACCACCAGCTA
TTCTACCTTCTGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_009831.1\|WP_041421860.1\|5194772_5195342_-\|S-(hydroxymethyl)glutathione-synthase	unknown	unknown	gnl\|CDD\|235451
NC_009831.1\|WP_012144568.1\|5200198_5201203_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270359
NC_009831.1\|WP_150104373.1\|5186591_5186837_-\|sortase-B-protein-sorting-domain-containing-protein	unknown	unknown	unknown
NC_009831.1\|WP_190273230.1\|5192112_5193228_-\|S-(hydroxymethyl)glutathione-dehydrogenase/class-III-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176260
NC_009831.1\|WP_012144564.1\|5195409_5196561_-\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341467
NC_009831.1\|WP_012144567.1\|5198441_5199650_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NC_009831.1\|WP_190273176.1\|5188428_5189157_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270422
NC_009831.1\|WP_012144552.1\|5184311_5184713_-\|MAPEG-family-protein	unknown	unknown	gnl\|CDD\|226311
NC_009831.1\|WP_083758969.1\|5193961_5194309_-\|phosphate-starvation-inducible-PsiE-family-protein	unknown	unknown	gnl\|CDD\|377613
NC_009831.1\|WP_012144559.1\|5191178_5192018_-\|S-formylglutathione-hydrolase	unknown	unknown	gnl\|CDD\|178061
NC_009831.1\|WP_083758968.1\|5189848_5190373_-\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|376515
NC_009831.1\|WP_012144556.1\|5189254_5189968_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187615
NC_009831.1\|WP_012144558.1\|5190526_5190853_-\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|224987
NC_009831.1\|WP_012144571.1\|5203440_5204655_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369347
NC_009831.1\|WP_012144569.1\|5201289_5202189_+\|proline/glycine-betaine-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226644
NC_009831.1\|WP_012144565.1\|5196890_5197760_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176159
NC_009831.1\|WP_012144566.1\|5197786_5198047_-\|hypothetical-protein	unknown	unknown	unknown
NC_009831.1\|WP_012144570.1\|5202181_5203441_+\|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226643
NC_009831.1\|WP_012144553.1\|5185225_5186446_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NC_009831.1\|WP_150104374.1\|5186880_5188296_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225387

Protein	Function_ID	Function_description	E-value
NC_009831.1\|WP_041421860.1\|5194772_5195342_-\|S-(hydroxymethyl)glutathione-synthase	gnl\|CDD\|235451	PRK05417, PRK05417, glutathione-dependent formaldehyde-activating enzyme; Provisional.	2.1262e-132
NC_009831.1\|WP_012144568.1\|5200198_5201203_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270359	cd13641, PBP2_HisX_like, Substrate-binding domain of ABC-type histidine transporter involves in betaine and proline uptake; the type 2 periplasmic-binding protein fold. This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to certain quaternary ammonium compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as glycine betaine, proline betaine, choline, and carnitine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.10754e-108
NC_009831.1\|WP_190273230.1\|5192112_5193228_-\|S-(hydroxymethyl)glutathione-dehydrogenase/class-III-alcohol-dehydrogenase	gnl\|CDD\|176260	cd08300, alcohol_DH_class_III, class III alcohol dehydrogenases. Members identified as glutathione-dependent formaldehyde dehydrogenase(FDH), a member of the zinc dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes or ketones. Like many zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these FDHs form dimers, with 4 zinc ions per dimer. The medium chain alcohol dehydrogenase family (MDR) have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding.	0
NC_009831.1\|WP_012144564.1\|5195409_5196561_-\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341467	cd08188, PDDH, 1,3-Propanediol (1,3-PD) dehydrogenase. This family includes 1,3-propanediol (1,3-PD) dehydrogenase, a key enzyme in the microbial production of 1,3-PD that has been previously characterized as the product of dhaT gene in Klebsiella pneumoniae. 1,3-PD dehydrogenase is a member of the family III metal-dependent polyol dehydrogenases, which are shown to require a divalent metal ion for catalysis. However, some members of this family showed a dependence on Fe(2+) or Zn(2+) for activity.	0
NC_009831.1\|WP_012144567.1\|5198441_5199650_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	9.67304e-98
NC_009831.1\|WP_190273176.1\|5188428_5189157_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270422	cd13704, PBP2_HisK, The periplasmic sensor domain of histidine kinase receptors; the type 2 periplasmic binding fold protein. This subfamily includes the periplasmic sensor domain of the histidine kinase receptors (HisK) which are elements of the two-component signal transduction systems commonly found in bacteria and lower eukaryotes. Typically, the two-component system consists of a membrane-spanning histidine kinase sensor and a cytoplasmic response regulator. The two-component systems serve as a stimulus-response coupling mechanism to enable microorganisms to sense and respond to changes in environmental conditions. Extracellular stimuli such as small molecule ligands and ions are detected by the N-terminal periplasmic sensing domain of the sensor kinase receptor, which regulate the catalytic activity of the cytoplasmic kinase domain and promote ATP-dependent autophosphorylation of a conserved histidine residue. The phosphate is then transferred to a conserved aspartate in the response regulator through a phospho-transfer mechanism, and the activity of the response regulator is in turn regulated. The sensor domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space through their function as an initial high-affinity binding component. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.82221e-20
NC_009831.1\|WP_012144552.1\|5184311_5184713_-\|MAPEG-family-protein	gnl\|CDD\|226311	COG3788, COG3788, Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only].	1.2946e-17
NC_009831.1\|WP_083758969.1\|5193961_5194309_-\|phosphate-starvation-inducible-PsiE-family-protein	gnl\|CDD\|377613	pfam06146, PsiE, Phosphate-starvation-inducible E. Phosphate-starvation-inducible E (PsiE) expression is under direct positive and negative control by PhoB and cAMP-CRP, respectively. The function of PsiE remains to be determined.	1.3457e-12
NC_009831.1\|WP_012144559.1\|5191178_5192018_-\|S-formylglutathione-hydrolase	gnl\|CDD\|178061	PLN02442, PLN02442, S-formylglutathione hydrolase.	1.00881e-138
NC_009831.1\|WP_083758968.1\|5189848_5190373_-\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|376515	pfam01288, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK).	3.04175e-14
NC_009831.1\|WP_012144556.1\|5189254_5189968_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187615	cd05357, PR_SDR_c, pteridine reductase (PR), classical (c) SDRs. Pteridine reductases (PRs), members of the SDR family, catalyzes the NAD-dependent reduction of folic acid, dihydrofolate and related compounds. In Leishmania, pteridine reductase (PTR1) acts to circumvent the anti-protozoan drugs that attack dihydrofolate reductase activity. Proteins in this subgroup have an N-terminal NAD-binding motif and a YxxxK active site motif, but have an Asp instead of the usual upstream catalytic Ser. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	2.66527e-53
NC_009831.1\|WP_012144558.1\|5190526_5190853_-\|multidrug-efflux-SMR-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	4.38665e-21
NC_009831.1\|WP_012144571.1\|5203440_5204655_+\|hypothetical-protein	gnl\|CDD\|369347	pfam07396, Porin_O_P, Phosphate-selective porin O and P. This family represents a conserved region approximately 400 residues long within the bacterial phosphate-selective porins O and P. These are anion-specific porins, the binding site of which has a higher affinity for phosphate than chloride ions. Porin O has a higher affinity for polyphosphates, while porin P has a higher affinity for orthophosphate. In P. aeruginosa, porin O was found to be expressed only under phosphate-starvation conditions during the stationary growth phase.	0.000244541
NC_009831.1\|WP_012144569.1\|5201289_5202189_+\|proline/glycine-betaine-ABC-transporter-permease	gnl\|CDD\|226644	COG4176, ProW, ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism].	8.93844e-125
NC_009831.1\|WP_012144565.1\|5196890_5197760_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176159	cd08470, PBP2_CrgA_like_1, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 1. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.19965e-128
NC_009831.1\|WP_012144570.1\|5202181_5203441_+\|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein	gnl\|CDD\|226643	COG4175, ProV, ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism].	2.1331e-179
NC_009831.1\|WP_012144553.1\|5185225_5186446_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	1.71288e-62
NC_009831.1\|WP_150104374.1\|5186880_5188296_+\|hypothetical-protein	gnl\|CDD\|225387	COG2831, FhaC, Hemolysin activation/secretion protein [Intracellular trafficking and secretion].	2.5353e-05

>NC_009831.1|WP_190273230.1|5192112_5193228_-|S-(hydroxymethyl)glutathione-dehydrogenase/class-III-alcohol-dehydrogenase
MKSKAAVAWAVGEPLSMEIVDVMPPQKGEVRVKMIATGVCHTDAFTLSGDDPEGIFPCILGHEGGGIVESIGEGVTSVQVGDHVIPLYTPECGECKFCKSGKTNLCQKIRETQGKGLMPDGTTRFSKDGVDIFHYMGTSTFSEYTVLPEISLAKVNPEAPLEEVCLLGCGVTTGMGAVMNTAKVEEGATVAIFGMGGIGLSAVIGATMAKASRIIVIDINESKFELARKLGATDFINPKDYDKPIQDVIVELTDGGVDYSFECIGNVNVMRSALECCHKGWGESVVIGVAGAGQEISTRPFQLVTGRVWKGSAFGGVKGRSELPEYVERYMAGEFKLNDFITHTMGLEQVNDAFDLMHEGKSIRTVIHFDK
>NC_009831.1|WP_012144559.1|5191178_5192018_-|S-formylglutathione-hydrolase
MTVESISVNKSFGGWHKQYSHHSKTLNCGMRFAIYLPPQASNGKKVPVLYWLSGLTCTDENFMQKAGVQALAAELGIAIVAPDTSPRGDDVADDEGYDLGKGAGFYVNATQAPWNRHYHMYDYVVDELPKLIESMFPVSDKRSIAGHSMGGHGALVIALRNSDAYQSVSAFSPISNPINCPWGKKALTAYLGRDSATWTEYDSSALMRQATKFVPALVDQGDADDFLVEQLKPEVLEAAAKVNGYPLELNYREGYDHSYYFISSFIENHLRFHAEHLGN
>NC_009831.1|WP_012144558.1|5190526_5190853_-|multidrug-efflux-SMR-transporter
MSWIFLLLGVMAEALSHVALKATDGFTRPLPAAMVILGHLTAFIFLGQAMKGMPVGVVHALWAGMAIVTVTLLSALFYRQHLDMTAWVGMLFVALGVVMINLSQGHSH
>NC_009831.1|WP_083758968.1|5189848_5190373_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MFYYLSIGTNITPELNAVSITSALCQNFGVVIGFPFIYTEPVGIESEHRFLNSLAVIESAKEPGDIKQMTNSIETSLGRDRTALDCSLADRVADIDIVTCSDKLDFSLFLSSGESYVSSLLTVDKSRYVDLTQYGLPPTDGPTAINFNTRSGNIMIVEQESHGLKDRHITTFER
>NC_009831.1|WP_012144556.1|5189254_5189968_+|SDR-family-NAD(P)-dependent-oxidoreductase
MRTIVITGSSRRLGLFLVEKFLSMGDTVIAITRSPSQNFQSISSEHLQLIQIDSYDQFGITKAMQEIETLAERVDLLINNASMYDVDPENFEELENHYLSLFNVHMLFPTLLITALKEHMYSESTPGVVVNITDIYADNPNPEYALYCSTKSGLESLTQSFAKKFSPGIRCNSIMPGPIQFLEQHTEHQKSEVYKETLLPFEGGYMPVFQAVTFLLDNHYVTGTSIKVDGGRSICRG
>NC_009831.1|WP_190273176.1|5188428_5189157_+|transporter-substrate-binding-domain-containing-protein
MKIVCHEFAPFSYQDQQQNITGILVEIARLACQDWPQGCEIELLPNKRAKQQFNQGLAHGHFQGWNEERALTTWFSIPLLQTEYGFYSPLAQPLTDLKQTSGKNIGAFGPSNTLTSLINIDRQQVRLGLPPMEIILSSSGDEQPLKMLHKRRFDAYYVNKEVGAYYAKHLGLNDLYYLSSGQPIHYFIGFKMKHNEYETIKAFNHLLVKLYQNHRFDEIFAKWKMIPSPLLPTEFPDLNVPY
>NC_009831.1|WP_150104374.1|5186880_5188296_+|hypothetical-protein
MILNKLPFSKESRISQKDLEEAQRNLRSEPYIRDAKISFSKRDPQADTPAEGETVLVETWDNWSLLPTISFSRSGGDSEFSVGIKEDNLLGYGVRTRMNYQSDADRTGYKLAFEAPLDNFIKHSKLGVSFYDNSDGQSKQLYFYKPFYTLDTKDSYSITYLDDLRNDTLKQNGMDINEFEVKQDFINLVYGWRISKNDNARSRIITGLTQDKNQFSHVDTYPGSRLPQDRDFIYPWVAYEFLQDDYTVLNNVHLINNNEDFNLGWHHYLKFGLETNDTDSSSPFGYHINWKTTRGYKDEAELLLLEFNGTSTLATTQDDFYRINASAEYFYQIHPKWTTYAKTRISTSKNNYLDQTFALGDDTGIRGYPNDYQHGDNQWLLTAELRHYPHINLYQLAELGWAAFVDVGQAFGGPDENNEVSAPIGSLGIGARIFSSHSSYGNVAHIDFSVPFTSGEEVNSWEWRFQVKNHF
>NC_009831.1|WP_150104373.1|5186591_5186837_-|sortase-B-protein-sorting-domain-containing-protein
MKKLSGSDSSKMGLLVTIILLSFFPLVGSPSIEFTSSPQLAVEAKRLAMKRDRYDLLPCIGSPYMSTFRLAEEKVNSFLTI
>NC_009831.1|WP_012144553.1|5185225_5186446_+|threonine/serine-exporter-family-protein
MNNEEFLEKRRFIIKLGKSLHKFGTPAYRLEAHLQAVSELLGLEGYFLISPTAMTFVLQHDTDQEYNHVARVKPGELDLGALARTDELVEELVSGKRTLQEALERLDEIANKPNAYGSLLTLLAFGCSAGAFAMLMGTSWNDVFWSALLGFMVYGLVYRAERSKRMAEMLEPLAAILCALVASGIAQLDPHINLPVVILSGIIIFVPGLALTLGLAELAARDLISGTARVMDACMLLFKLYFGAIFGMVIGKAIFGEAIYFEPDPVPQVAIWSAVPILSMALVIIFKARMKDSPWGVLAGIVAFFSSMLGGIYLGDSIGIFFGAFAVGVYSNLFARWMKAPASIALLQGIVILVPGSKTYIGLNTLILGETMLNQSHIGSQIFLIFMSLVAGLIFANVAVSPRRTL
>NC_009831.1|WP_012144552.1|5184311_5184713_-|MAPEG-family-protein
MSVAISGLYISITAILVVMFAMRVIQLRRKHKIGLGSSGNEELRLANRVHANLVENAPIAMILLLVAEQNHLPGLFLHILGIVWVIGRILHAIGLTQGRGGYHLGRFWGGLLSWLVILILAGINFGYFFFSLG
>NC_009831.1|WP_083758969.1|5193961_5194309_-|phosphate-starvation-inducible-PsiE-family-protein
MTLVILWSVVDVGRVLFIEVITPPYGLMDMQDILAIFGSFLAVLIAIEIFQNITIYLKEEVIHVQIVIASALMAISRKIIILDFKEVGPEYVWASAAVIIALGVTYWLVSGKRDH
>NC_009831.1|WP_041421860.1|5194772_5195342_-|S-(hydroxymethyl)glutathione-synthase
MKTLIHPQVDNGVVADRDGFAGGTLLCKCSSKPVEVTVGAQTAHNHVCGCSKCWKPEGALFAQIAVVSRDHVSVTANADKLAIVDESAAIQRHACRECGTHMYGRIENTGHPFHGLDFIHTELSAEKGWSAPEFAAFVSSIIESGAAPESMGDVRNTLKELGLEPYDCLSPVLMDAIATHVASHVVSNG
>NC_009831.1|WP_012144564.1|5195409_5196561_-|iron-containing-alcohol-dehydrogenase
MSTTFYMPPMSLMGQNAIKQLGDELNARNFNKALIVTDKALVDIKLVEKLTDELASHNINFAIFDGVKPNPTEKNIDQGLALLEAQKCDFVISFGGGSSHDCAKGIALVAANGGHIRDYSKGVHLSAKPQLPLVTVNTTAGTAAEMTIFAIVTNEEDETKYPIVDKNLTPIIAVNDSELMVAMPKFLTAATGMDALTHAVEAYVSTAATPITDASAIKAIELIAQNLKTAVDNGEDREARDAMQYGEYLAGMAFSNASLGYVHSMAHQLGGVYDLVHGLCNAILLPVVSRFNAAEKVERFADVAKAMGVDTAGMAFSDAAEAGILAIEKLSASVGTDQKLSDLGVKEDKLEFMAINALNDACSLTNPRKATTQEVINIFKKVM
>NC_009831.1|WP_012144565.1|5196890_5197760_+|LysR-family-transcriptional-regulator
MFNWEGVSEFVAVAEAESFTKAAKRLGISTAQVSRQVSALETRMATKLFHRTTRKVSVTEVGRIYYQHCRQVLDGLEEAERAITNLQSTPRGLLKITAPVTYGERTLAPLVNDFIAKYPELEVKVSLTNQKVDLIDEGYDLAIRLGQLEDSSMMAKRLGSRTQYVCASPGYVSTFGIPHSLSELEQHNCLLGTLDYWRFQENGKTRNVRVKGNLSCNSGHALVDAAIKGIGIIQLPDYYVLPYLEDGQLIPLLEQNRQPDEGIWALYPHNRHLSPKVRMLLDYLSEALE
>NC_009831.1|WP_012144566.1|5197786_5198047_-|hypothetical-protein
MYHIVKKNIYNRIFGEWMWERNILWLFSFLCMLDALMVSGDHYQNFLRDGAFHAGLLIGISGYLSELRYNFFKNLRNDELDDEAEK
>NC_009831.1|WP_012144567.1|5198441_5199650_+|NAD(P)/FAD-dependent-oxidoreductase
MSRVVIVGGGAAGLELASILGRSVNCQDEVILVDGETHHYWKPRFHEIAAGTFDNDLDTLCYFSHGAKNGYMHYQGWMTDIKREEKQLVVSKPNGETDFVNYDYLVIAIGAISNDFATPGALEHCLFLDSPEQARSSWLQISSLLRSGHQRAINIVGAGATGLELAAELAKVNAGLEPNPHAAKLKINLIEATDRVLPNSPLKMSHQAQLMLEKYNINVMLNTRIASVEQQGMTTSDGLTISADIQFWAAGIKAPNWLKNIGGLESNSFNQLMVQQTLASTLDPNIFALGDCAAIPQGEGVMVPPKAQAANRAAVHLAKSLTGLMRGKQLTPFIYKDGGMVVAIGHNFAISTMMNDKLILKGRVIRRLYDTIFRLHQKTVSGVLTMSRLIIAKRLKCIFQPN
>NC_009831.1|WP_012144568.1|5200198_5201203_+|ABC-transporter-substrate-binding-protein
MKSMILIGGLLLSSATHQAFAEEQCGKVTIADMNWSSASLIANVDRFILEHGYGCEAELIPGDTMPTSTSMVEKGEPDIAPEIWSNSVKELIERGVSDKRLTIAGNSLSEGGEEGFWVPQYMVDKDPSLTTIEGIIAKVKTFEHPEDPDRGAFYGCPAGWGCQLSAENLYRALKLSDAGFDLIDPGSGAGLSGSIARAYEREKPWFGYYWAPTAVLGKYKMAKVDFGSGTDADHFRDCIAKVECAEPKVTMYPSALVQTVTTTAFAEKSTREFEYLGTRSLTNAQMNGLLAWMEDNQADGNIAAEYFLMNHEDTWLKWVPADVAAKVKAAIEAL
>NC_009831.1|WP_012144569.1|5201289_5202189_+|proline/glycine-betaine-ABC-transporter-permease
MADFSWLSKFPKMDRSTLLEIRKYLDGTFRDFSREYGDVIESFFDPLLDFLIWFEKLLVQSPWWAVLLSITALVYLASRSWKLSLGVVVSFLLIGYFGMWEDTMRTLSIITVCTLLAIVLGVPIGILMARSNRTQSLVTPILDVMQTMPAFVYLIPVVMLLGIGKVPGVIAVVIYAIPPVIRLTNLGIRLVDKEVLEAATAYGANPMQRLMGVQLPLASPTIMAGINQTIMMALGMVVIASMIGVKGLGQPVLKSITNQYFTLGLFNGLAIVALAIIFDRASQAYAKRSQKHMQGGQHD
>NC_009831.1|WP_012144570.1|5202181_5203441_+|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein
MTNESQTEPLIQIKDLFKVFGKKPAKVMPMVRDGLSKDEILAKTGHTVGLKAINLDIHQGEIFVIMGLSGSGKSTLIRHFNRLIDPTEGQILVEGIDVMKLNTKELEQFRRNKMAMVFQRFGLMPHKSVLENVAYGLSVQGIDKVTRNAKATQWLETVGLAGYEDQYPSQLSGGQQQRVGLARALCTDAEILLMDEAFSALDPLIRSEMQDQLIELQKELHKTIIFITHDLDEALRIGDRIAILKDGNLVQVGEPVDILLNPADDYVEAFVKDVNRPRALTVETVMKPPAYRLTADTIGEALKQMKRIPANYAYYVTDEGFQGVVCQEALEDAVKTDKEALMEDFKVEEMTPISQDALLESIIPATMESDFPLPVIDSDGDLQGELSRTHLADVLSDFYTDGADDSADAEKQNSTKEDK
>NC_009831.1|WP_012144571.1|5203440_5204655_+|hypothetical-protein
MIRYTLAASCIALALAANANATPVDEELEALKARIEQLESEQTPVTEEKENAIKFGGAARFQYSYEDYDVDNKDRGGDFDFDVFRIDVNGNVDDVIFSAQYRWHQYMDVIHHAWVGYNFDEKQQAKIGITQVPFGILTWASNSFFFSSNFYTGLEDDYDMGLNYTYNGDANRLDLAFYKNDEQGGLDGYVSDRSERYSYDVVGVRLAGEGIYDAPSEGKAAAESNTLNARYAHNLAFGDVAVELGVSAQAGQLEIQDGTDGDHVAAALHSVINYDRWNVKLQLTDYTYDVDGMDVERMVVGAYAFYDSIPAEATSYVANVAYSLPVSMGPISNLTFYNDYSLVTDKPGVQEDTFMNVTGVAITAGGLYTYVDFVVAENQPFIGGSMVGDGETNKRLNINFGYYF

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_009831_6	6.1\|4447527\|25\|NC_009831\|CRISPRCasFinder	4447527-4447551	25	NC_009831.1	4447292-4447316	0	1.0

1. spacer 6.1|4447527|25|NC_009831|CRISPRCasFinder matches to position: 4447292-4447316, mismatch: 0, identity: 1.0

aatgtgagctcccctgacaaggcgg	CRISPR spacer
aatgtgagctcccctgacaaggcgg	Protospacer
*************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_009831_6	6.1\|4447527\|25\|NC_009831\|CRISPRCasFinder	4447527-4447551	25	NZ_CP027375	Escherichia coli strain 05-3629 plasmid unnamed2, complete sequence	111359-111383	5	0.8
NC_009831_6	6.1\|4447527\|25\|NC_009831\|CRISPRCasFinder	4447527-4447551	25	NZ_CP027458	Escherichia coli strain 88-3493 plasmid unnamed, complete sequence	91918-91942	5	0.8
NC_009831_6	6.1\|4447527\|25\|NC_009831\|CRISPRCasFinder	4447527-4447551	25	NZ_CP028383	Escherichia coli strain RM10466 plasmid pRM10466-2, complete sequence	4465-4489	5	0.8
NC_009831_6	6.1\|4447527\|25\|NC_009831\|CRISPRCasFinder	4447527-4447551	25	CP027580	Escherichia coli strain 2013C-4282 plasmid unnamed1	22501-22525	5	0.8
NC_009831_6	6.1\|4447527\|25\|NC_009831\|CRISPRCasFinder	4447527-4447551	25	CP027581	Escherichia coli strain 2013C-4282 plasmid unnamed2, complete sequence	108938-108962	5	0.8
NC_009831_6	6.1\|4447527\|25\|NC_009831\|CRISPRCasFinder	4447527-4447551	25	NZ_CP028610	Escherichia coli strain 142 plasmid pTA142-3, complete sequence	53708-53732	5	0.8

1. spacer 6.1|4447527|25|NC_009831|CRISPRCasFinder matches to NZ_CP027375 (Escherichia coli strain 05-3629 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.8

aatgtgagctcccctgacaaggcgg	CRISPR spacer
gttgtgagctcacctgacaaggcat	Protospacer
. ********* ***********.

2. spacer 6.1|4447527|25|NC_009831|CRISPRCasFinder matches to NZ_CP027458 (Escherichia coli strain 88-3493 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.8

aatgtgagctcccctgacaaggcgg	CRISPR spacer
gttgtgagctcacctgacaaggcat	Protospacer
. ********* ***********.

3. spacer 6.1|4447527|25|NC_009831|CRISPRCasFinder matches to NZ_CP028383 (Escherichia coli strain RM10466 plasmid pRM10466-2, complete sequence) position: , mismatch: 5, identity: 0.8

aatgtgagctcccctgacaaggcgg	CRISPR spacer
gttgtgagctcacctgacaaggcat	Protospacer
. ********* ***********.

4. spacer 6.1|4447527|25|NC_009831|CRISPRCasFinder matches to CP027580 (Escherichia coli strain 2013C-4282 plasmid unnamed1) position: , mismatch: 5, identity: 0.8

aatgtgagctcccctgacaaggcgg	CRISPR spacer
gttgtgagctcacctgacaaggcat	Protospacer
. ********* ***********.

5. spacer 6.1|4447527|25|NC_009831|CRISPRCasFinder matches to CP027581 (Escherichia coli strain 2013C-4282 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.8

aatgtgagctcccctgacaaggcgg	CRISPR spacer
gttgtgagctcacctgacaaggcat	Protospacer
. ********* ***********.

6. spacer 6.1|4447527|25|NC_009831|CRISPRCasFinder matches to NZ_CP028610 (Escherichia coli strain 142 plasmid pTA142-3, complete sequence) position: , mismatch: 5, identity: 0.8

aatgtgagctcccctgacaaggcgg	CRISPR spacer
gttgtgagctcacctgacaaggcat	Protospacer
. ********* ***********.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1507119 : 1516294

Staphylococcus_phage(57.14%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012141616.1\|1507119_1508217_-	metallophosphoesterase	A0A1V0SLL4	Klosneuvirus	2.6e-15	27.8
WP_012141617.1\|1508520_1510188_-	energy-dependent translational throttle protein EttA	A0A1V0SKJ1	Klosneuvirus	1.0e-39	27.3
WP_012141618.1\|1510700_1511957_+	serine hydroxymethyltransferase	A0A219Y950	Aeromonas_phage	3.0e-92	52.6
WP_012141619.1\|1512112_1512562_+	transcriptional regulator NrdR	NA	NA	NA	NA
WP_012141620.1\|1512627_1513752_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	8.1e-49	34.3
WP_012141621.1\|1513756_1514419_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	4.3e-26	32.5
WP_012141622.1\|1514528_1515632_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	2.5e-66	39.1
WP_012141623.1\|1515811_1516294_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	3.0e-29	45.7

DBSCAN-SWA_2

2574151 : 2585752

uncultured_Caudovirales_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012142471.1\|2574151_2576665_+	DNA translocase FtsK 4TM domain-containing protein	A0A218M9A2	Mycobacterium_phage	5.4e-85	49.9
WP_012142472.1\|2576779_2577406_+	outer membrane lipoprotein chaperone LolA	NA	NA	NA	NA
WP_012142473.1\|2577415_2578747_+	replication-associated recombination protein A	G3MBE0	Bacillus_virus	2.6e-78	39.9
WP_012142474.1\|2578739_2579114_+	fluoride efflux transporter CrcB	A0A2H4J148	uncultured_Caudovirales_phage	1.8e-05	37.0
WP_012142475.1\|2579132_2580419_+\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	1.6e-96	44.3
WP_012142476.1\|2580853_2581189_-	TusE/DsrC/DsvC family sulfur relay protein	NA	NA	NA	NA
WP_041421646.1\|2581299_2581581_-	sulfurtransferase complex subunit TusB	NA	NA	NA	NA
WP_041422111.1\|2581580_2581937_-	sulfurtransferase complex subunit TusC	A0A2H4J8C0	uncultured_Caudovirales_phage	6.1e-11	32.8
WP_012142479.1\|2582007_2582397_-	sulfurtransferase complex subunit TusD	A0A2H4JA39	uncultured_Caudovirales_phage	2.9e-22	44.9
WP_012142480.1\|2582562_2583222_-	Bax inhibitor-1/YccA family protein	A0A2H4JFM9	uncultured_Caudovirales_phage	1.1e-34	42.0
WP_012142481.1\|2583471_2584374_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_041421647.1\|2584492_2585752_+	Bcr/CflA family multidrug efflux MFS transporter	S4TR35	Salmonella_phage	1.0e-15	23.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_009831

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection