CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_012467	Streptococcus pneumoniae P1031, complete sequence	2 crisprs	DEDDh,cas3,DinG,RT	0	0	11	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_012467_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012467_1

130757-130852

Orphan

Consensus_repeat	Method
AATGTGTAAGATTTTTATATATAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012467_1

>merge|NC_012467|1|130757-130852|CRISPRCasFinder
AATGTGTAAGATTTTTATATATAATTTTTCTACACATACATTGTACATCTAAAAGAAAGCCCTGTCAAGAGAAATGTGTAAAATTTTTATATATAA

>NC_012467|1|1|130757-130852|CRISPRCasFinder
AATGTGTAAGATTTTTATATATAA	TTTTTCTACACATACATTGTACATCTAAAAGAAAGCCCTGTCAAGAGA
AATGTGTAAAATTTTTATATATAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012467.1\|WP_000273863.1\|130412_130739_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_012467.1\|WP_000836451.1\|137909_138482_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NC_012467.1\|WP_001075102.1\|122902_123826_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012467.1\|WP_001189271.1\|138533_138854_-\|hypothetical-protein	unknown	unknown	unknown
NC_012467.1\|WP_000096213.1\|132101_133241_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133016
NC_012467.1\|WP_000838912.1\|136996_137668_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	unknown	unknown	gnl\|CDD\|224674
NC_012467.1\|WP_000198692.1\|129832_130426_-\|DUF1700-domain-containing-protein	unknown	unknown	gnl\|CDD\|227053
NC_012467.1\|WP_001233685.1\|128928_129840_-\|DUF4097-domain-containing-protein	unknown	unknown	gnl\|CDD\|372574
NC_012467.1\|WP_000723960.1\|139617_141726_+\|bacteriocin-associated-integral-membrane-family-protein	unknown	unknown	gnl\|CDD\|273736
NC_012467.1\|WP_000744903.1\|130877_132044_-\|CynX/NimT-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340897
NC_012467.1\|WP_000714588.1\|121959_122889_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_012467.1\|WP_001230167.1\|139278_139563_+\|lactococcin-972-family-bacteriocin	unknown	unknown	gnl\|CDD\|370615
NC_012467.1\|WP_000808443.1\|127801_128866_-\|membrane-protein	unknown	unknown	gnl\|CDD\|370966
NC_012467.1\|WP_001140347.1\|126764_127625_+\|DUF4299-domain-containing-protein	unknown	unknown	gnl\|CDD\|339103
NC_012467.1\|WP_000500040.1\|136115_136988_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	unknown	unknown	gnl\|CDD\|129801
NC_012467.1\|WP_000800407.1\|123909_125385_+\|DUF3502-domain-containing-protein	unknown	unknown	gnl\|CDD\|378792
NC_012467.1\|WP_000148253.1\|121206_121467_+\|hypothetical-protein	unknown	unknown	unknown
NC_012467.1\|WP_001035706.1\|133308_135159_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224011
NC_012467.1\|WP_000200890.1\|135461_136094_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319798
NC_012467.1\|WP_001030032.1\|125656_126643_+\|rhodanese-related-sulfurtransferase	unknown	unknown	gnl\|CDD\|234663

Protein	Function_ID	Function_description	E-value
NC_012467.1\|WP_000273863.1\|130412_130739_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	8.86871e-19
NC_012467.1\|WP_000836451.1\|137909_138482_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	5.58739e-13
NC_012467.1\|WP_001075102.1\|122902_123826_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.04007e-69
NC_012467.1\|WP_000096213.1\|132101_133241_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133016	cd02525, Succinoglycan_BP_ExoA, ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.	9.65723e-108
NC_012467.1\|WP_000838912.1\|136996_137668_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	gnl\|CDD\|224674	COG1760, SdaA, L-serine deaminase [Amino acid transport and metabolism].	1.1908e-89
NC_012467.1\|WP_000198692.1\|129832_130426_-\|DUF1700-domain-containing-protein	gnl\|CDD\|227053	COG4709, COG4709, Predicted membrane protein [Function unknown].	3.2841e-63
NC_012467.1\|WP_001233685.1\|128928_129840_-\|DUF4097-domain-containing-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	1.5652e-38
NC_012467.1\|WP_000723960.1\|139617_141726_+\|bacteriocin-associated-integral-membrane-family-protein	gnl\|CDD\|273736	TIGR01654, unnamed_protein_product, bacteriocin-associated integral membrane (putative immunity) protein. This model represents a family of integral membrane proteins, most of which are about 650 residues in size and predicted to span the membrane seven times. Nearly half of the members of this family are found in association with a member of the lactococcin 972 family of bacteriocins (TIGR01653). Others may be associated with uncharacterized proteins that may also act as bacteriocins. Although this protein is suggested to be an immunity protein, and the bacteriocin is suggested to be exported by a Sec-dependent process, the role of this protein is unclear. [Cellular processes, Toxin production and resistance].	0
NC_012467.1\|WP_000744903.1\|130877_132044_-\|CynX/NimT-family-MFS-transporter	gnl\|CDD\|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.00309e-125
NC_012467.1\|WP_000714588.1\|121959_122889_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	8.41366e-143
NC_012467.1\|WP_001230167.1\|139278_139563_+\|lactococcin-972-family-bacteriocin	gnl\|CDD\|370615	pfam09683, Lactococcin_972, Bacteriocin (Lactococcin_972). These sequences represent bacteriocins related to lactococcin. Members tend to be found in association with a seven transmembrane putative immunity protein.	4.66681e-22
NC_012467.1\|WP_000808443.1\|127801_128866_-\|membrane-protein	gnl\|CDD\|370966	pfam10310, DUF5427, Family of unknown function (DUF5427). This is a domain of unknown function. Family members found in Saccharomyces cerevisiae, are synthetic lethal with genes involved in maintenance of telomere capping. However, experimental evidence is yet to verify the exact function of family members and the domain.	9.90573e-05
NC_012467.1\|WP_001140347.1\|126764_127625_+\|DUF4299-domain-containing-protein	gnl\|CDD\|339103	pfam14132, DUF4299, Domain of unknown function (DUF4299). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 275 and 313 amino acids in length. There are two conserved sequence motifs: RGF and DAY. There are two completely conserved residues (P and D) that may be functionally important.	6.60514e-120
NC_012467.1\|WP_000500040.1\|136115_136988_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	gnl\|CDD\|129801	TIGR00718, Probable_L-serine_dehydratase_alpha_chain, L-serine dehydratase, iron-sulfur-dependent, alpha subunit. This enzyme is also called serine deaminase. L-serine dehydratase converts serine into pyruvate in the gluconeogenesis pathway from serine. This model describes the alpha chain of an iron-sulfur-dependent L-serine dehydratase, found in Bacillus subtilis. A fairly deep split in a UPGMA tree separates members of this family of alpha chains from the homologous region of single chain forms such as found in Escherichia coli. This family of enzymes is not homologous to the pyridoxal phosphate-dependent threonine deaminases and eukaryotic serine deaminases. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	1.44295e-105
NC_012467.1\|WP_000800407.1\|123909_125385_+\|DUF3502-domain-containing-protein	gnl\|CDD\|378792	pfam12010, DUF3502, Domain of unknown function (DUF3502). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is about 140 amino acids in length. This domain is found associated with pfam01547.	4.24398e-44
NC_012467.1\|WP_001035706.1\|133308_135159_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224011	COG1086, COG1086, Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	0
NC_012467.1\|WP_000200890.1\|135461_136094_-\|HAD-family-hydrolase	gnl\|CDD\|319798	cd04302, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065. 5'-nucleotidases dephosphorylate nucleoside 5'-monophosphates to nucleosides and inorganic phosphate. Purified Pseudomonas aeruginosa PA0065 displayed high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	8.29103e-98
NC_012467.1\|WP_001030032.1\|125656_126643_+\|rhodanese-related-sulfurtransferase	gnl\|CDD\|234663	PRK00142, PRK00142, rhodanese-related sulfurtransferase.	0

>NC_012467.1|WP_000273863.1|130412_130739_-|PadR-family-transcriptional-regulator
MYFPTSSALIEFLILAVLEQGDSYGYEISQTIKLIANIKESTLYPILKKLEGNSFLTTYSREFQGRMRKYYSLTNGGIEQLLTLKDEWALYTDTINGIIEGSIRHDKN
>NC_012467.1|WP_000198692.1|129832_130426_-|DUF1700-domain-containing-protein
MTRTEYLTQLELYLKKLPEADRIEAMDYFRELFDDAGVEGEEELIASLGTPKEAAHEVLSNLLDKKINEAPAQKNNRQILHIALLALLAAPIGIPLGIAILVTLFAILVAALTVILAFFAVSILGIIGGFLFLVESFTVLAQAKSAFILIFGSGLLAIGASSLVLLGISYVARFFGLLIVRLVQFVLKKRKRGNQHA
>NC_012467.1|WP_001233685.1|128928_129840_-|DUF4097-domain-containing-protein
MRKWTKGFLIFGVVTTVIGFILLFVGIQSDGIKSLLSMSKEPIYDSRTEKLTFGKEVENLEITLHQHALTITDSFDDQIHISYHPSLSAHHDLITNQNDRTLSLTDKKLSETPFLSSGIGGILHIASSYSSRFEEVILQLPKGRTLKGINISANRGQTTIINASLENATLNTNSYILRIEGSRIKNSKLTTPNIVNIFDTVLTDSQLESTENHFHAENIQVHGKVELTAKDYLRIILNQKESQRINWDISSNYGSIFQFTREKPESRGTELSNPYKTEKTDVKDQLIARSDDNIDLISTPSRR
>NC_012467.1|WP_000808443.1|127801_128866_-|membrane-protein
MKQEWFESNDFVKTTSKNKPEEQAQEVADKAEETIADLDTPIEKNTQLEEEVPQAEVELESQQEEKIEAPEDSEARTEIEEKKASNSTEEEPDLSKETEKVTIAEESQEALPQQKATTKEPLLISKSLESPYIPDQAPKSRDKWKEQVLDFWSWLVEAIKSPTSKLETSITHSYTAFLLLILFSASSFFFSIYHIKHAYYGHIASINSRFPEQLAPLTLFSIISILVATTLFFFSFLLGSFVVRRFIHQEKDWTLDKVLQQYSQLLAIPIFLTAIASFFAFFDSLRFTALLCVISIGIILLASLHIITRPSQASETDSFYQLFLSVLVNGVIILLFFVAEVALIGDYLRILAFL
>NC_012467.1|WP_001140347.1|126764_127625_+|DUF4299-domain-containing-protein
MAKTFFIPNKQSILGEQEILNAKSILALLDGLESHSYDVVYLRQPLNRLEYIECAIVGQSQFLFKVSYADGQKAYRVDLPDLLTKTDWQIIKSFLDALLAYTGTDIEGLDGFDFEAYFQASIQAYLADPVARFTICQGIFNPIFFSRENLKSFLEADGLAQFEARVRAVQETDAYFARVSFYQDGEGKVHGVYHLAQGVKTVLPREPFVPAAYIEQLVDKEVQWEIDLVQITGDGSKPEDYEAIARLDYAKFLEVLPLSFYHQLDANQIEVQPILDKDFKALAQEE
>NC_012467.1|WP_001030032.1|125656_126643_+|rhodanese-related-sulfurtransferase
MAKDIRVLLYYLYTPIENAEQFAADHLAFCKSIGLKGRILVADEGINGTVSGDYETTQKYMDYVHSLPGMEELWFKIDEESEQAFKKMFVRYKKEIVHLGLEDNDFDNDINPLETTGAYLSPKEFKEALLDKDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKDPEVQGELWDGKMYVFDERIAVDVNHVNPTIVGKDWFDGTPCERYVNCGNPFCNRRILTSEENEDKYLRGCSHECRVHPRNRYVSKNELTQAEVIERLAAIGESLDQAATV
>NC_012467.1|WP_000800407.1|123909_125385_+|DUF3502-domain-containing-protein
MKNWKKYAFASASVVALAAGLAACGNLTGNSKKAADSGDKPVIKMYQIGDKPDNLDELLANANKIIEEKVGAKLDIQYLGWGDYGKKMSVITSSGENYDIAFADNYIVNAQKGAYADLTELYKKEGKDLYKALDPAYIKGNTVNGKIYAVPVAANVASSQNFAFNGTLLAKYGIDISGVTSYETLEPVLKQIKEKAPDVVPFAIGKVFIPSDNFDYPVANGLPFVIDLEGDTTKVVNRYEVPRFKEHLKTLHKFYEAGYIPKDVATSDTSFDLQQDTWFVREETVGPADYGNSLLSRVANKDIQIKPITNFIKKNQTTQVANFVISNNSKNKEKSMEILNLLNTNPELLNGLVYGPEGKNWEKIEGKENRVRVLDGYKGNTHMGGWNTGNNWILYINENVTDQQIENSKKELAEAKESPALGFIFNTDNVKSEISAIANTMQQFDTAINTGTVDPDKAIPELMEKLKSEGAYEKVLNEMQKQYDEFLKNKK
>NC_012467.1|WP_001075102.1|122902_123826_+|carbohydrate-ABC-transporter-permease
MAKKKIKKEKIDNVGIHSFSKKADIFFSIISGLIALSCILPFVFVIIISVTDEKSLLQYGYSFFPSQFGLDGFEFLAQFKDKILQALFISVFVTVVGTLTNVFITTTYAYAISRTTFKYRRFFTIFVLLSMLFNAGLVPGYIMVTRVLQLGDTVWALIVPMLLSPFNIILMRSFFKKTIPEAILESARIDGASEARIFFQICLPLSLPGIATITLLTALGFWNDWFNALLYIKSDNLYPLQYLLMQIQQNMDYIAKAVGLTGQLGVALPKETGRMAMVVVATLPIAILYPFFQRYFVKGLTIGGVKE
>NC_012467.1|WP_000714588.1|121959_122889_+|sugar-ABC-transporter-permease
MKKFSKTLRDNWIFLLMVLPGTLWLILFFYIPVFGNVVAFKDYHMTSNGFIDSIINSKWVGLDNFRFLFSSRDAFIITRNTVLYNLGFIFLGLVVSVGIAIILSELRSKRMVKIFQTSMLFPYFLSWVIISFFTDAFLNIDKGVFNHLLESLGLKEVNFYADLGIWPYLLLFLGIWKGFGYSSVMYYATIMGIDPTYYEAATVDGASKWQRIRNVTIPQLTPLVTVLTILAVGNIFRADFGLFYQIPHNAGQLYNVTNVLDVYVFNGLTQTADIGMAAAAGLYQSVVGLILVILSNLLARRVDPNSALF
>NC_012467.1|WP_000148253.1|121206_121467_+|hypothetical-protein
MTGVSNPTTDSARLVLAEAKKAFADDSLTEQGLRDILQTVKDAIASLESIKESQSATKDGGQTAGKETAGEDESANQTQEISQGIK
>NC_012467.1|WP_000744903.1|130877_132044_-|CynX/NimT-family-MFS-transporter
MKKQSLFFVPGIILIGVSLRTPFTVLPIILGNISQGLEVEVSSLGVLTSLPLLMFTLFSPFSTRLAQKIGLEHLFTYSLFFLTIGSLIRLINLPLLYLGTLMVGASVAVINVLLPSLIQANQPKKIGFLTTLYVTSMGIATALASYLAVPITQASSWKGLILLLTLLCLATFLVWLPNHRYNHRLAPQTKQKSQIKVMRNKQVWAIIIFSGFQSLIFYTAMTWLPTMSIHAGLSSHEAGLLTSILSLISIPFSMTIPSLTTSLSTRNRQLMLTLVSLAGVVGISMLFFPINNFIYWLAIHLLIGTATSALFPYLMVNFSLKTSAPEKTAQLSGLSQTGGYILAAFGPTLFGYSFDLFHSWVPAVAALLLIDILMTVALFTVDRADKIL
>NC_012467.1|WP_000096213.1|132101_133241_+|glycosyltransferase-family-2-protein
MSSKVSGFQDKNGKVLKIMIEWWKGKFRRVVVTQNVESLLVSIVISAYNEEKYLPGLIEDLKNQTYPKENIEILFINAMSTDGTTAIIQQFIKEDAEFNSIRLYNNPKKNQASGFNLGVKHSVGGLILKIDAHSKVTESFVMNNVAVIQQGEFVCGGPRPTIVKGKGKWAETLHLVEENMFGSSIANYRNSSEDRYVSSIFHGMYKREVFQKVGLVNEQLGRTEDNDIHYRIREHGYKIRYSPSILSYQYIRPTFKKMLHQKYSNGLWIGLTSHVQFKCLSLFHYVPCLFVLSLVFSLALLPITFVFITLLLGAYFLLLSLLSLLTLLTLLKHKNGFLIVMPFLLFSIHFAYGLGTIVGLIRGFKWKKEYKGTVIYLEK
>NC_012467.1|WP_001035706.1|133308_135159_+|polysaccharide-biosynthesis-protein
MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILFYGLINPAPVDYIIYTSLAFLFYQLMVDFWGLSASISRYSKITDFMKIFFGVTASSVLSYSICYAFLPLFSIRFIILFILLSAFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGAGDGGALFMDSYQHPTSELELVGILDKDSKKKGQKLGGIPVLGSYDNLPELAKRHQIERVIVAIPSLDPSEYERILQMCNKLGVKCYKMPKVETVVQGLHQAGTGFQKIDITDLLGRQEIRLDESRLGAELTGKTILVTGAGGSIGSEICRQVSRFNPERIVLLGHGENSIYLVYHELIRKFQGIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFKNNIRGTYNVARAVDEAKVPKMVMISTDKAVNPPNVMGATKRVAELIVTGFNQRSQSTYCAVRFGNVLGSRGSVIPVFERQIAEGGPVTVTDFRMTRYFMTIPEASRLVIHAGAYAKDGEVFILDMGKPVKIYDLAKKMVLLSGHTESEIPIVEVGIRPGEKLYEELLVSTELVDNQVMDKIFVGKVNVMPLESINQKIGEFRTLSGDELKQAIIAFANQTTHIE
>NC_012467.1|WP_000200890.1|135461_136094_-|HAD-family-hydrolase
MTSITAIFFDLDGTLVDSSIGIHNAFTYTFKELGVPSPDAKTIRGFMGPPLESSFATCLSKDQISEAMQIYRSYYKAKGIYEAQLFPQIIDLLEELSSSYPLYITTTKNTSTAQDMAKNLEIHHFFDGIYGSSPEAPHKADVIHQALQTHQLAPEQAIIIGDTKFDMLGARETGIQKLAVTWGFGEQADLLNYQPDYIAHKPLEVLAYFQ
>NC_012467.1|WP_000500040.1|136115_136988_-|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha
MFYSIKELVEQADLDFQGNVAELMITTEFELTGREREEVFLLMERNLEVMKASVQLGLNENKSRSGLTGGDAAKLDHYIKNEKTLSDYTILSAARNAIAVNEHNAKMGLVCATPTAGSAGCLPSVLTAAIEKLDLSHEQQLDFLFAAGAFGLVIANNASISGAEGGCQAEVGSASAMSAAALTLAAGGTPYQASQAIAFVIKNMLGLICDPVAGLVEVPCVKRNAMGASFAFIAADMALAGIESKIPVDEVIDAMYQVGASMPTAFRETAEGGLATTPTGRRLQKEIFGE
>NC_012467.1|WP_000838912.1|136996_137668_-|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta
MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPTEVEFQLFNSFAKTYRGHGTDLALVAGILGMDTDDPEIPNSLEIAHKRGIKIVWTIQKDSNAPHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDIPGMIALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHNVNFFK
>NC_012467.1|WP_000836451.1|137909_138482_+|LysM-peptidoglycan-binding-domain-containing-protein
MKSITKKIKATLAGVAALFAVFSPSFVSAQESSTYTVKEGDTLSEIAETHNTTVEKLAENNHIDNIHLIYVDQELVIDGPVAPVATPAPATYAAPAAQDETVSAPVVSETVVSTVSGSEAEAKEWIAQKESGGSYTATNGRYIGRYQLTDSYLNGDYSAENQERVADAYVAGRYGSWTAAKNFWLNNGWY
>NC_012467.1|WP_001189271.1|138533_138854_-|hypothetical-protein
MQRLEVYKNYQHLYDLQIAILLNLSTLYLYNQDKNMCKQICYTLLEDAKNKKSYDRLAICYVRIGICTDDSKLIQKGFSLLELTEETSMLSHLKKEVEIYYQAKER
>NC_012467.1|WP_001230167.1|139278_139563_+|lactococcin-972-family-bacteriocin
MRKLVKIGVASLMVCSILASTSVLAVWVDGGQWNYGVGWSGNFGYSDYLHSTRSHTATVKDGNKFSKDRAEAEAWARASIFKFPPTGMEYFYGF
>NC_012467.1|WP_000723960.1|139617_141726_+|bacteriocin-associated-integral-membrane-family-protein
MKKISHLCMLLLLLCTTFFVFNVNYTREVVRIQEMGKTVDSLDLYLKDINEPAASVLRFFEDVSKEYKVSIIKTDSGDEVVKSGVFDKDTFPYQEFGISSLDFTTDGEGVYSNKEISNKLGTIPTFLKAKPIQLMTFQTYIKDTSRSLNGRYTITSTQEMDKDRIVQKWSDFFKIDQATLLEPTYKSAVEVINRDLLLSAIVFVLAILLLVLVTVYQPMMEMKRVGVQKLLGFQDRAVLADVVKGNLYLLLGGALVINLGVFFLLDYKPKDLFPMLWLSHFLLLQLYLFISWLTYLLIQKMTISSLLKGFSSFKFGLLFNYLMKIGTTILLTVLLVGVGKSLEQENKELDYQKQWISQGNYLTLETFQLNDNLWQEQLAGSGKALDYFYRFYQDLVEKTQAGYVQSSSLPVKNFVQSEQIQQYQLTDTVDVYYANRNFLKSKGFKLPDTGIKKVILMPASTKGEEDKNQLLGKLIAFHSMKYEEQQKRTIEEMDVEIAYYEGDWSFFPYSDKRKENLSNPIISLVNDSDMMWDEKASLSTTGLNNPIKIENTVQHQKEITELVEKLSDGNYLKFSSIQAIQQEKVDSYRDAVRNFNLLFALFGLLSMMISYFLLVITFLLKRRDIITKKFMGWKLVDRYRPLLVLLLLGYSFPLLVLIFFAHAFLPLLLFAGFTCLDILFVLVLASRMEKRSLVELLKGGIL

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Crispr_ID: NC_012467_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012467_2

1059441-1059553

Orphan

Consensus_repeat	Method
ACAACAGGAGTAGATGAAAATGGAAACTTGATTGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012467_2

>merge|NC_012467|2|1059441-1059553|CRISPRCasFinder
ACAACAGGAGTAGATGAAAATGGAAACTTGATTGAACCACCTGTTAACGACATCCCAGAATATACTGAGCCAGTAGGTACAACAGGAGTGGATGAAAATGGAAACTTGATTGA

>NC_012467|2|2|1059441-1059553|CRISPRCasFinder
ACAACAGGAGTAGATGAAAATGGAAACTTGATTGA	ACCACCTGTTAACGACATCCCAGAATATACTGAGCCAGTAGGT
ACAACAGGAGTGGATGAAAATGGAAACTTGATTGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012467.1\|WP_000857133.1\|1070717_1070948_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378900
NC_012467.1\|WP_044811956.1\|1042034_1042481_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271189
NC_012467.1\|WP_000645900.1\|1066919_1067369_+\|hypothetical-protein	unknown	unknown	unknown
NC_012467.1\|WP_000822768.1\|1064699_1065479_+\|replication-initiator-protein-A	unknown	unknown	gnl\|CDD\|369151
NC_012467.1\|WP_000131079.1\|1039982_1040429_-\|YueI-family-protein	unknown	unknown	gnl\|CDD\|227793
NC_012467.1\|WP_001809343.1\|1038216_1038588_+\|HAD-IB-family-phosphatase	unknown	unknown	gnl\|CDD\|319803
NC_012467.1\|WP_000022813.1\|1040592_1041897_+\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NC_012467.1\|WP_000174775.1\|1050876_1052055_+\|hypothetical-protein	unknown	unknown	unknown
NC_012467.1\|WP_000772338.1\|1043739_1047015_+\|ATP-dependent-nuclease-subunit-B	unknown	unknown	gnl\|CDD\|274291
NC_012467.1\|WP_000159602.1\|1064529_1064703_+\|hypothetical-protein	unknown	unknown	unknown
NC_012467.1\|WP_001210976.1\|1065577_1066936_+\|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl\|CDD\|273211
NC_012467.1\|WP_000840776.1\|1067754_1067988_+\|hypothetical-protein	unknown	unknown	unknown
NC_012467.1\|WP_000417184.1\|1052263_1058743_+\|G5-domain-containing-protein	unknown	unknown	gnl\|CDD\|369436
NC_012467.1\|WP_001844778.1\|1038532_1038757_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319803
NC_012467.1\|WP_001291561.1\|1068754_1069972_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|334163
NC_012467.1\|WP_000566528.1\|1067361_1067742_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224311
NC_012467.1\|WP_000814511.1\|1070053_1070257_-\|excisionase	unknown	unknown	gnl\|CDD\|286167
NC_012467.1\|WP_000706434.1\|1038870_1039986_+\|glycerate-kinase	unknown	unknown	gnl\|CDD\|224840
NC_012467.1\|WP_000767228.1\|1047011_1050662_+\|helicase-exonuclease-AddAB-subunit-AddA	unknown	unknown	gnl\|CDD\|274299
NC_012467.1\|WP_000821271.1\|1067990_1068593_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806

Protein	Function_ID	Function_description	E-value
NC_012467.1\|WP_044811956.1\|1042034_1042481_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	3.29836e-15
NC_012467.1\|WP_000821271.1\|1067990_1068593_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	4.63944e-09
NC_012467.1\|WP_000822768.1\|1064699_1065479_+\|replication-initiator-protein-A	gnl\|CDD\|369151	pfam06970, RepA_N, Replication initiator protein A (RepA) N-terminus. This of family of predicted proteins represents the N-terminus (approximately 80 residues) of replication initiator protein A (RepA), a DNA replication initiator in plasmids. Most proteins in this family are bacterial, but archaeal and eukaryotic members are also included.	8.20296e-31
NC_012467.1\|WP_000131079.1\|1039982_1040429_-\|YueI-family-protein	gnl\|CDD\|227793	COG5506, COG5506, Uncharacterized conserved protein [Function unknown].	9.24487e-56
NC_012467.1\|WP_001809343.1\|1038216_1038588_+\|HAD-IB-family-phosphatase	gnl\|CDD\|319803	cd07500, HAD_PSP, phosphoserine phosphatase (PSP), similar to Methanococcus Jannaschii PSP and Saccharomyces cerevisiae SER2p. This family includes Methanococcus jannaschii PSP, and Saccharomyces cerevisiae phosphoserine phosphatase SER2p, EC 3.1.3.3, which participates in a pathway whereby serine and glycine are synthesized from the glycolytic intermediate 3-phosphoglycerate; phosphoserine phosphatase catalyzes the hydrolysis of phospho-L-serine to L-serine and inorganic phosphate, the third reaction in this pathway. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	5.00146e-40
NC_012467.1\|WP_000022813.1\|1040592_1041897_+\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NC_012467.1\|WP_000772338.1\|1043739_1047015_+\|ATP-dependent-nuclease-subunit-B	gnl\|CDD\|274291	TIGR02774, putative_ATP-dependent_exonuclease_subunit_B, ATP-dependent nuclease subunit B. DNA repair is accomplished by several different systems in prokaryotes. Recombinational repair of double-stranded DNA breaks involves the RecBCD pathway in some lineages, and AddAB (also called RecAB) in other. The AddA protein is conserved between the firmicutes and the alphaproteobacteria, while the partner protein is not. The partner may be designated AddB, as in Bacillus and in alphaproteobacteria, or RexB as in Streptococcus and Lactococcus. Note, however, that RexB proteins lack an N-terminal GxxGxGK[ST] ATP-binding motif found in Bacillus subtilis and related species, and this difference may be important; this model represents specifically RexB proteins as found in Streptococcus and Lactococcus. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_012467.1\|WP_001210976.1\|1065577_1066936_+\|DNA-(cytosine-5-)-methyltransferase	gnl\|CDD\|273211	TIGR00675, Modification_methylase, DNA-methyltransferase (dcm). All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	2.17762e-81
NC_012467.1\|WP_000857133.1\|1070717_1070948_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378900	pfam12645, HTH_16, Helix-turn-helix domain. This domain appears to be a helix-turn-helix domain suggesting that this might be a transcriptional regulatory protein. Some members of this family are annotated as conjugative transposon domains.	4.41299e-26
NC_012467.1\|WP_000417184.1\|1052263_1058743_+\|G5-domain-containing-protein	gnl\|CDD\|369436	pfam07580, Peptidase_M26_C, M26 IgA1-specific Metallo-endopeptidase C-terminal region. These peptidases, which cleave mammalian IgA, are found in Gram-positive bacteria. Often found associated with pfam00746, they may be attached to the cell wall.	0
NC_012467.1\|WP_001844778.1\|1038532_1038757_+\|HAD-family-hydrolase	gnl\|CDD\|319803	cd07500, HAD_PSP, phosphoserine phosphatase (PSP), similar to Methanococcus Jannaschii PSP and Saccharomyces cerevisiae SER2p. This family includes Methanococcus jannaschii PSP, and Saccharomyces cerevisiae phosphoserine phosphatase SER2p, EC 3.1.3.3, which participates in a pathway whereby serine and glycine are synthesized from the glycolytic intermediate 3-phosphoglycerate; phosphoserine phosphatase catalyzes the hydrolysis of phospho-L-serine to L-serine and inorganic phosphate, the third reaction in this pathway. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.19358e-24
NC_012467.1\|WP_001291561.1\|1068754_1069972_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|334163	pfam00589, Phage_integrase, Phage integrase family. Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.	6.12129e-48
NC_012467.1\|WP_000566528.1\|1067361_1067742_+\|hypothetical-protein	gnl\|CDD\|224311	COG1393, ArsC, Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism].	7.23137e-20
NC_012467.1\|WP_000706434.1\|1038870_1039986_+\|glycerate-kinase	gnl\|CDD\|224840	COG1929, COG1929, Glycerate kinase [Carbohydrate transport and metabolism].	0
NC_012467.1\|WP_000767228.1\|1047011_1050662_+\|helicase-exonuclease-AddAB-subunit-AddA	gnl\|CDD\|274299	TIGR02785, ATP-dependent_helicase/nuclease_subunit_A, helicase-exonuclease AddAB, AddA subunit, Firmicutes type. AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_012467.1\|WP_000814511.1\|1070053_1070257_-\|excisionase	gnl\|CDD\|286167	pfam09035, Tn916-Xis, Excisionase from transposon Tn916. The phage-encoded excisionase protein Tn916-Xis adopts a winged-helix structure that consists of a three-stranded anti-parallel beta-sheet that packs against a helix-turn-helix (HTH) motif and a third C-terminal alpha-helix. It is encoded for by Tn916, which also codes for the integrase Tn916-Int. The protein interacts with DNA by the insertion of helix alpha-2 into the major groove and the contact of the hairpin that connects strands beta-2 and beta-3 with the adjacent phosphodiester backbone and/or minor groove. Tn916-Xis stimulates phage excision and inhibits viral integration by stabilizing distorted DNA structures.	1.3564e-15

>NC_012467.1|WP_000417184.1|1052263_1058743_+|G5-domain-containing-protein
MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQETAGVHYKYVADSELSSEEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSKNERQALVSGASLAALGILIFAVSKKKVKNKTVLHLVLVAGMGNGVLVSVHALENHLLLNYNTDYELTSGEKLPLPKEISGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDYNVTPNFVDHPSTVQAIQEQTPVSSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQLAEHKNLETKKEEKISPKEKTGVNTLNPQDEVLSGQLNKPELLYRDETIETKIDFQEEIQENPDLAEGTVRVKQEGALGKKVEIVRIFSVNNEEVSREIISTSTTAPVSRIVEKGTKKAQVIKEQAETGAEHKEVQSGAIVEPAIQPELPAAVLTDKGESAVQPELPEAVVSDKGVPEVQPALPEAVMTDKGDPEQVEPLPEYTGVQAGAIVEPEKVEPEYAGVQAGAIVEPEQVAPLPEYTGVQAGAIVEPEKVEAPKEYTGVQAGAIVEPEKVEAPKEYTGVQAGAIVEPEKVEPSKEYTGVQAGAIVEPEQIAPLPEYTGVQAGAIVEPEKVEALKEYTGKIEQPSAEDTKPNNENTNTPEEMSIQKKSSALINMNFITDSSKVTGVGSATFIAPNVLLTVAHNFINNSTDNTTGEFRGDKSKNVYEWVTPDGQKGTFTANNIHFYNKKDYPKGFIYDLAVIKLPETTGREHVELVKNYSKVNLNDKLNVHGYPAGKYTHLKDATVEMEQEYANNTYGVQYQGGNPGMSGGGIFNANGEVIGVHQNGAQNRSGGLILSPTQLAWIKSIIAGNEIPPVYDELYRHKDEKKDDAKDEKEVIKKLELRNISSVELYSKDGNKYRHVTSLASLPSNAENYFMKVKSENFKDVMLPVTSITNDTKDNRDVYKIVASANSLIQHENNNVLENYTYYLPKTQQSETGVYTSFKNLVDAMNSNPNGTFRLGATMDAREVELPDGQESYVNNVFHGILVGTNNEKYYAIYNLKKPLFGELNGATVEKLSLKDVNISAKDDTATLAKEANNNTHIDNVHADGAIAGERSIGGLVSQVNNSTISNSSYTGRITNTYKTVASYQIGGLVGKLSGPRGLIDKSFASIDLSSNATQGDQSIGGIVGAVENSALISNSYAEGNLNNVQRFANVGGVVGNLWDPVGGLEKSGRLSNVLSDVNVTNGNAIAGYNFNGIKANGTYSNKNNKVVNVVQEDDEILTKDSTVQRGEVLEDAQIKEKKATFVSKNTIKTEDFNFSSRYVTDYKNLENADSSKEKVYKNIEKLLPFYNRETIVKYGNLVETSSNLYNKELLSVVPMKDKEVISDINKNKSSINKLLLYYADNTSETLNVNYQTDFSNVAEYRIGGTNLIYTPNTLLRNYQNILDEVLPALNSVEYKSEAIRKVLDVSKDVSLTELYLEEQFNTTKTNLKDSLTKLLTADAAIAENNNKVIDNYVIEKIKNNKEALLLGLTYLERWYDFKYRDTKAKDLVMYHLDFFGKSNSSALDNVIELGKSGYNNLLAKNNVITYNVLLAKNYKTNNLFDALEKYRKAFVPDKTNNEWFKEQTKAYIVEEKSTIKEVSDKQSIAGSPYSIGVYDRLTSPSWKYPSMVLPLLTLPEKSVFIIANISTIGFGAYDRYRSKEHPAGTDLNDYVEKKAKEAAVRFRDHYDYWYRILDDKNKEKLYRSVLVYDAFRFGTDEKEDKDTYQATFETNHPAIKHFFGPAGNNVVHNSNGAYATGDAFYYMAYRMLDKDGAVTYTHEMTHNSDREIYLGGYGRRNGLGPEFYAKGLLQAPDHPNDPTVTINSILKYDQSEESTRLQVADPTQRFGSVDDLNKYMHNMFDVIYMLEILEGKAVAKLDTNQKYDLLRKIENEYKPDPDGNSVYATNVVRRLKPEELTKLTTFNSLIEHDIITRRGYVDEATYKRNGYYTINLFSPIYSALSSKIGTPGDLMGRRIAFELLAAKGYKDGMVPYISNQYEKEAKAQGKVITSYGKQIGLVTDEIVLSKVFNNQYNSWIDFKKDMYKEREDKFGKLNKVSFIDPNGSWARQQKVTIDNINRLEKMIEDAVKFDAEDEVAKLYPETNSRVLKLKKAIFKAYLDQTGDFRSSIFENKK
>NC_012467.1|WP_000174775.1|1050876_1052055_+|hypothetical-protein
MTLPVRKSLHDAVLQASKADTWEQATKEWNEVSLIFNGIGRSNCVCGNAIKYAYELFNGVTGQRLFPIGSDCVRHFHRLSLDQQLEEEEKLLRKVENLTRKAQKKEKIKVNKSDFDERLLKWLWEKGVFKPNRGNQFAPERDYQLFLEVFQGGSWTKAEPKKKARMEEVLEKCIKPFLLGKSDDQLYLVKLGKEKIDYEQELRIQAEKERKKRDKIAKQYADNLVLAMGPAERAYQDYFGFTETLTQEERKWEKILFGKNRAERAIKAKQYQKELEKDQRIASQDPIERKQKQTWLLNSYFRELPEEKARFSRLLLEYRKSGEVPFSTEYLSDHLIDFFYKMKAFEFEIAPEQVRDFLKKSLQEDHRSSAQGSWIEGILLNCLKPFLERLVI
>NC_012467.1|WP_000767228.1|1047011_1050662_+|helicase-exonuclease-AddAB-subunit-AddA
MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSGQNILVSASAGSGKTFVMAERILDQLARGVEISQLFISTFTVKAATELKERLEKKISKKIQETDDVDLKQHLGRQLADLPNAAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLLLENEVFHEVFEAHYQGKQKESFSHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWLSESFLKGFEKADFTSEKEKLTEQIKQALWDLERFFRYHLDNDAKEFAKAAYLENVQLILDEIGSLNQEFDSQAYQAVLARVVAISKEKNGRALTNASRKADLKPLADAYNEERKTQFTKLGQLSDQIAILDYQERYHGDTWKLAKTFQSFMSDFVEAYRQRKRQENAFEFADISHYTIEILENFPQVRESYQERFHEVMVDEYQDTNHIQERMLELLSNGHNRFMVGDIKQSIYRFRQADPQIFNEKFQRYAQNPQEGKLILLKENFRSSSEVLSATNDVFERLMDQEVGEINYDNKHQLVFANTKLTPNPDNKAEFLLYDKDDTGEEEESQTETKLTGEMRLVIKEILKLHQEKGVAFKEIALLTSSRSRNDQILLALSEYGIPVKTDGEQNNYLQSLEVQVMLDTLRVIHNPLQDYALVALMKSPMFGFDEDELARLSLQKAEDKVHENLYEKLVNAQKMASSQKGLIHTALAEKLKQFMDILASWRLYAKTHSLYDLIWKIYNDRFYYDYVGALPNGPARQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDLSSVAVAPPKDAVELMTIHKSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIAKMETGAVEDHYPKTIKLSIPSLTYRQNEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKGSREKLEVKQYPAAKNGKLNSNTRLQARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTREAIGELETKSPLQDSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKFYEPVMDMEGVEIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTLASLTETLKQVQTSQAVRDKINLDKILAFFDTVLGQEILANTDHLYREQPFSMLKRDQKSQEDFVVRGILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIENIEKYLILLGKDEVQVVKV
>NC_012467.1|WP_000772338.1|1043739_1047015_+|ATP-dependent-nuclease-subunit-B
MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKERAVLECLSQQASFSITVTRFAQMARYLVLNDLPAKTTLDDIGLGLAFYKCLAELDPKDLRVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRADLLLIFEKVTAYLNQGQLAQGSQLSHLIEAIENDKVSSDFNQITLVIDGFTRFSAEEERVVDLLHGKGVEIVIGAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLESSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILLGDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINLLRTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQIFTKSHHGKFNLERLNVLRLRILAPLETLFASRKQKAENLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVLEQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYAIGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSARKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSLVAYHQQGEMSDTEQDLTFVKVLSRVIGKKLDLQGLENPAIPTSPSSKTLAKDTLQALYPAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLRPDARSHGNFLHRIFERALQLPNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIETIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPHFFNGLNSQLPTYLAALKREGKQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKYQGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYTENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWFEKIREELNR
>NC_012467.1|WP_044811956.1|1042034_1042481_-|tyrosine-type-recombinase/integrase
MRKHGLISKSTSKGYYQVAIPFMRLFCLVLVSIDYINCLSETTDKNWHKSDRIFVTNTGKPVHSSILSKSLQRANERLKKPIPKHLSPHIFRHTTISILSENKIPLKTITDRVGHSDSEVTTSIYTHVTKNMKDEAINVLDKVMKKIF
>NC_012467.1|WP_000022813.1|1040592_1041897_+|phosphopyruvate-hydratase
MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYGGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEIPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMILPVGAPTFKEALRYGAEIFHALKKILKSRGLETAVGDEGGFAPRFEGTEDGVETILAAIEAAGYVPGKDVFIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGKKVQLVGDDFFVTNTDYLARGIQEGAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK
>NC_012467.1|WP_000131079.1|1039982_1040429_-|YueI-family-protein
MTDLSKQLLEKAHGGLKINPDEQRRYLGTFEERVLGYVDIDTANSPQLEKGFLFILENLQEKAEPLFVKISPTIEFDKQVFYLKEAKETDSQATIVSEEHITSPLGLVIHSNAPVQVEEKDLRLAFPKLWEVKKEEPAKTSLWKKWFS
>NC_012467.1|WP_000706434.1|1038870_1039986_+|glycerate-kinase
MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDGGEGTVDAIRHSLDLKEKWIQVTDPSGQKEAMRYFQKGELALFEVADLVGLGKIPLEKRNPLQIQTCGIGELILHLISKGIKDIYIGVGGTASNDGGLGIAAGLGYQFYDRDGNVLPASDQSLLNLASVSTENCYKIPEGVQIHILADVVSPLCGHQGATYTFGNQKGLHPTMFAVVDQAIQDFYEKFSPATLEIKGAGAGGGLAGGLCAFAQASIVSGIDTCLDLINFDKKVSDADLVVVGEGRLDSQSFAGKAPIGVAKRTPVGVPVIAICGSLAEDLPPLPFENIQAVFSILEKSEPLEDSLKNASLYLERTAANIGHLLNMCKI
>NC_012467.1|WP_001844778.1|1038532_1038757_+|HAD-family-hydrolase
MERLAKSLGIAYFTANQLEVKEGLLTGKLVGQIISPQVKKETLEKWRKKLKLSKERTVAIGDGVNNLLMLKSAE
>NC_012467.1|WP_001809343.1|1038216_1038588_+|HAD-IB-family-phosphatase
MSQVKGLCVLDVDGTLILEEVIDLLGREAGHEAEISQITSRAMRGELVFESSLRKRVSLLEGLPILVFDNVFNSIHLSLNVPEFISILQKNGILVGLVSGGFTPIVGEISKIPWYCLFHCQPA
>NC_012467.1|WP_000159602.1|1064529_1064703_+|hypothetical-protein
MTKELQSSRYIVISFLVREMGIDIVEAISLMAELEKSGLVQLESSGDLTLKELGGAL
>NC_012467.1|WP_000822768.1|1064699_1065479_+|replication-initiator-protein-A
MKRITANQYQTSERYYKLPKILFEDEKYMDMKLEVKVAYSILKDRLELSLSRGWIDEEGAVYLVFSNSKLMKLLGCSKSKLLSIKKILKEYDLIDEVQQSSSEKGRLANKIYLGELSSTPVGNSNRPSVKKRLGQVENETAPVSHSAPRETEVSETKYSETDSLFIEDEEDRNTQPILKRKVEKVTKYDRDYIWGLVQDQFRREGFSETASEIAMTDFERIYQYALDNVRFVRRAEVLAEFVFNGLYSVWNNRVRKGGG
>NC_012467.1|WP_001210976.1|1065577_1066936_+|DNA-(cytosine-5-)-methyltransferase
MRFIDLFSGIGGFRLGMESVGHECIGFCEIDKFARKSYKSIFQTEGEIEFHDIRDVSDAEFKKLRGKVDIICGGFPCQAFSIAGRRLGFEDTRGTLFFEIARAAKQIQPRFLFLENVKGLLNHDKGRTFTTILTTLDELGFDVEWQLLNSKDFGVPQNRERVFIIGHSRKRGTRLLFPFRREGQTTNSETLKTLGNLNPSKSGMSGKVYYSEGLAPTLVRGKGEGFKVAIPCMTPDRLDKRQNGRRFKENQEPMFTLNTQDRHGIVVVGDLPTSFKETGRVYGSEGLSPTLTTMQGGDKIPKILIPEPIQFLKVREATKKGYAQAEIGDSINLERPSSQYRRGRVGKGIANTLTTSGQMGVVVASYEGEDKQVYHVAGVLIDGQFYRLRIRRITPKECFRLQGFPDWAFEAARKVSSNSQLYKQAGNSVTVPVIAAIAKKLKEIEEKDESAK
>NC_012467.1|WP_000645900.1|1066919_1067369_+|hypothetical-protein
MKALNKESILYCDELETELHDAEMMQLDEQIFLMPNYPCEFEVTFLDYYHKKHNYPLFYESYLQNIMEFLESQDIKNGADAFIDDNHNLVFVLYGQGYRAEGKEGILTTQVTVKAYDEDKKSINFSNLLDSLIVSEYQMEPNLWEVSHD
>NC_012467.1|WP_000566528.1|1067361_1067742_+|hypothetical-protein
MIDLYLSKNNHRNQLLLEFFQNYGIEVSCHSISEMTRDKLIEMMSYSSDCFEFLSPNLLRFKNRDNLRLTDFIEMILKNPELTIRLPLAVSNKRVYPNLNLEEARALLPRDTKQLIYMAQTHYLSN
>NC_012467.1|WP_000840776.1|1067754_1067988_+|hypothetical-protein
MAERFWENLSIILAERNISWIELTRKMFAGEFHYPSELNRLYQKIRHYKMEQRMPQSPWVERIVQVLDLDYEDLFRR
>NC_012467.1|WP_000821271.1|1067990_1068593_+|CPBP-family-intramembrane-metalloprotease
MKRIIPVYIFQQVNVLLVSLYLLKFLCIGELTILQIIYGASLISFLWMYGQRKQVAKVNMETRIKWIGIGFVSLLIISLYFSLIHAQESTNQANLIGLQHQVPWFSFLLFLINASMVEEFLYREILWNLVRKLDIRVALTSVLFALAHHPGTILAWCLYVSLGMFLGMVRYKSDLWGSMGLHLVWNLLVYSLLLFNKNKV
>NC_012467.1|WP_001291561.1|1068754_1069972_-|tyrosine-type-recombinase/integrase
MSEKRRDNKGRILKTGESQRKDGRYLYKYIDSFGEPQFVYSWKLVATDRVPAGKRDCISLREKIAELQKDIHDGIDVVGKKMTLCQLYAKQNAQRPKVRKNTETGRKYLMDILKKDKLGVRSIDSIKPSDAKEWAIRMSENGYAYQTINNYKRSLKASFYIAIQDDCVRKNPFDFQLKAVLDDDTVPKTVLTEEQEEKLLAFAKADKTYSKNYDEILILLKTGLRISEFGGLTLPDLDFENRLVNIDHQLLRDTEIGYYIETPKTKSGERQVPMVEEAYQAFKRVLANRKNDKRVEIDGYSDFLFLNRKNYPKVASDYNGMMKGLVKKYNKYNEDKLPHITPHSLRHTFCTNYANAGMNPKALQYIMGHANIAMTLNYYAHATFDSAMAEMKRLNKEKQQERLVA
>NC_012467.1|WP_000814511.1|1070053_1070257_-|excisionase
MKQTDIPIWERYTLTIEEASKYFRIGENKLRRLAEENKNANWLIMNGNRIQIKRKQFEKIIDTLDAI
>NC_012467.1|WP_000857133.1|1070717_1070948_-|helix-turn-helix-domain-containing-protein
MKTQYPMIPFPLIVKATDGDTEAINQILHHYRGYITKRSLRLMKDEYGNQSMVVDEVLRGRMETRLITKILSFEIK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

4381 : 87791

Streptococcus_phage(76.92%)

tRNA,protease,terminase,capsid,tail,transposase,integrase,bacteriocin,portal,head,holin

attL 24213:24233|attR 59704:59724

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000163932.1\|4381_4951_+\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_000258090.1\|4951_8461_+	transcription-repair coupling factor	NA	NA	NA	NA
WP_001234978.1\|8518_8785_+	RNA-binding S4 domain-containing protein	NA	NA	NA	NA
WP_000041909.1\|8777_9146_+	septum formation initiator family protein	NA	NA	NA	NA
WP_001224756.1\|9265_10534_+	serine hydrolase	NA	NA	NA	NA
WP_001208983.1\|10530_11808_+\|tRNA	tRNA lysidine(34) synthetase TilS	A7K9Y8	Acanthocystis_turfacea_chlorella_virus	2.5e-06	24.1
WP_000892184.1\|11811_12354_+	hypoxanthine phosphoribosyltransferase	A0A218MMB5	uncultured_virus	2.7e-10	28.9
WP_000744537.1\|12369_14328_+\|protease	ATP-dependent zinc metalloprotease FtsH	H8ZJI5	Ostreococcus_tauri_virus	5.4e-109	45.8
WP_000588897.1\|14449_14929_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_000939546.1\|22364_22601_+	hypothetical protein	NA	NA	NA	NA
WP_000205044.1\|22831_24118_+	adenylosuccinate synthase	L7Y4J5	Megavirus	2.7e-72	37.1
24213:24233	attL	NA	NA	NA	NA
WP_000876726.1\|24349_25498_-\|integrase	site-specific integrase	A0A1S5S8M0	Streptococcus_phage	1.6e-217	100.0
WP_001174227.1\|25672_26485_-	restriction endonuclease	A0A1S5S8D3	Streptococcus_phage	5.7e-129	100.0
WP_000285962.1\|26915_27179_-	type II toxin-antitoxin system RelE/ParE family toxin	A0A1S5S8E8	Streptococcus_phage	1.2e-43	100.0
WP_000156422.1\|27178_27412_-	hypothetical protein	A0A1S5S8D5	Streptococcus_phage	4.7e-36	100.0
WP_000495824.1\|27411_27780_-	helix-turn-helix transcriptional regulator	A0A1S5S8C4	Streptococcus_phage	3.2e-63	100.0
WP_001001334.1\|28064_28211_+	hypothetical protein	A0A141E188	Streptococcus_phage	2.5e-19	100.0
WP_000573356.1\|28254_28629_+	hypothetical protein	A0A1S5S8E6	Streptococcus_phage	3.5e-65	100.0
WP_000032100.1\|28621_28825_+	hypothetical protein	A0A1S5S8F3	Streptococcus_phage	1.2e-27	100.0
WP_001057654.1\|28841_29039_+	hypothetical protein	A0A1S5SEL5	Streptococcus_phage	3.6e-29	100.0
WP_001004503.1\|29049_29211_+	hypothetical protein	A0A1S5S8H5	Streptococcus_phage	4.5e-22	100.0
WP_000456433.1\|29205_29631_-	hypothetical protein	A0A1S5S8M8	Streptococcus_phage	2.1e-37	100.0
WP_001002346.1\|29684_30398_+	ORF6C domain-containing protein	A0A1S5S8E1	Streptococcus_phage	5.2e-134	100.0
WP_000370958.1\|30410_30668_+	hypothetical protein	A0A1S5SFD5	Streptococcus_phage	1.2e-43	100.0
WP_000462827.1\|30753_31074_+	hypothetical protein	A0A1S5S8E5	Streptococcus_phage	5.6e-48	100.0
WP_001156934.1\|31089_31386_+	hypothetical protein	A0A1S5S8D4	Streptococcus_phage	4.0e-48	100.0
WP_001289767.1\|31378_32206_+	phage replisome organizer N-terminal domain-containing protein	A0A1S5SCN0	Streptococcus_phage	3.5e-150	100.0
WP_000228214.1\|32345_33116_+	ATP-binding protein	A0A1S5S8G3	Streptococcus_phage	5.2e-140	100.0
WP_000470303.1\|33130_33325_+	hypothetical protein	A0A1S5SCY7	Streptococcus_phage	1.8e-28	100.0
WP_000891963.1\|33324_33552_+	hypothetical protein	A0A1S5S8I1	Streptococcus_phage	2.3e-40	100.0
WP_000233203.1\|33678_33846_+	hypothetical protein	A0A1S5SEY3	Streptococcus_phage	5.0e-24	100.0
WP_000872730.1\|33832_34042_+	hypothetical protein	A0A1S5S8G8	Streptococcus_phage	8.5e-29	100.0
WP_000969678.1\|34013_34343_+	hypothetical protein	A0A141E1Y9	Streptococcus_phage	2.3e-60	100.0
WP_000772905.1\|34332_34758_+	DUF1642 domain-containing protein	A0A1S5S8E4	Streptococcus_phage	1.2e-77	100.0
WP_000612387.1\|35268_35658_+	hypothetical protein	A0A1S5S8G9	Streptococcus_phage	4.7e-73	100.0
WP_001067627.1\|35657_35894_+	DUF3310 domain-containing protein	A0A1S5S8G0	Streptococcus_phage	6.0e-39	100.0
WP_153231720.1\|35890_36049_+	hypothetical protein	NA	NA	NA	NA
WP_000736391.1\|36260_36662_+	transcriptional activator	A0A1S5S8P9	Streptococcus_phage	6.2e-68	100.0
WP_000397552.1\|36850_37393_+\|integrase	site-specific integrase	A0A1S5S8G1	Streptococcus_phage	1.4e-99	100.0
WP_000238198.1\|37556_37748_+	hypothetical protein	A0A1S5S8H4	Streptococcus_phage	3.2e-30	100.0
WP_000282422.1\|37867_38188_+	HNH endonuclease	A0A1S5SFJ3	Streptococcus_phage	2.7e-58	100.0
WP_001118282.1\|38325_38718_+\|terminase	P27 family phage terminase small subunit	A0A1S5S8F2	Streptococcus_phage	1.6e-65	100.0
WP_000527303.1\|38710_40441_+\|terminase	terminase large subunit	A0A1S5S8L1	Streptococcus_phage	0.0e+00	100.0
WP_001002923.1\|40448_40667_+	hypothetical protein	A0A1S5SEK2	Streptococcus_phage	1.3e-32	100.0
WP_000510807.1\|40684_41887_+\|portal	phage portal protein	A0A1S5S8H6	Streptococcus_phage	8.8e-227	100.0
WP_001172113.1\|41870_42446_+\|head,protease	HK97 family phage prohead protease	A0A1S5S8L3	Streptococcus_phage	2.6e-104	100.0
WP_001037663.1\|42442_43615_+\|capsid	phage major capsid protein	A0A1S5S8J5	Streptococcus_phage	4.6e-180	99.7
WP_000120767.1\|43626_43917_+	hypothetical protein	A0A1S5S8Q9	Streptococcus_phage	7.7e-36	100.0
WP_000371962.1\|43919_44201_+\|head,tail	phage head-tail connector protein	A0A1S5S8H0	Streptococcus_phage	1.8e-45	100.0
WP_000267061.1\|44187_44487_+\|head	phage head closure protein	A0A1S5S8I2	Streptococcus_phage	3.7e-49	100.0
WP_000063886.1\|44483_44831_+	HK97 gp10 family phage protein	A0A1S5SEL8	Streptococcus_phage	8.8e-47	100.0
WP_000777003.1\|44827_45151_+	hypothetical protein	A0A1S5SEP5	Streptococcus_phage	3.5e-53	100.0
WP_000191278.1\|45162_45741_+	hypothetical protein	A0A1S5S8L9	Streptococcus_phage	2.6e-107	100.0
WP_001227145.1\|45752_46172_+	hypothetical protein	A0A1S5S8H9	Streptococcus_phage	8.7e-73	100.0
WP_000918322.1\|46449_49209_+	hypothetical protein	A0A1S5S8I3	Streptococcus_phage	2.4e-288	100.0
WP_000589852.1\|49205_49928_+	hypothetical protein	A0A1S5S8M4	Streptococcus_phage	1.8e-134	100.0
WP_001846667.1\|49928_53150_+\|tail	phage tail protein	A0A1S5S8K1	Streptococcus_phage	0.0e+00	99.9
WP_001091109.1\|56508_56712_+	hypothetical protein	A0A060QN53	Streptococcus_phage	1.3e-26	100.0
WP_001165344.1\|57076_57493_+\|holin	phage holin family protein	A0A1S5SCE8	Streptococcus_phage	1.9e-67	100.0
WP_001186237.1\|57496_57832_+\|holin	phage holin	A0A1S5S8N1	Streptococcus_phage	7.5e-51	100.0
WP_000350458.1\|57831_58788_+	N-acetylmuramoyl-L-alanine amidase family protein	A0A1S5S8I6	Streptococcus_phage	1.5e-144	100.0
WP_001209433.1\|59057_59237_-	hypothetical protein	Q3BLW4	Phage_SK137	3.5e-23	96.6
WP_001030863.1\|59378_59528_-	hypothetical protein	C5J952	Streptococcus_phage	9.1e-17	95.9
WP_000291875.1\|59809_60277_+	nucleoside deaminase	NA	NA	NA	NA
59704:59724	attR	NA	NA	NA	NA
WP_000701992.1\|60463_60907_+	dUTP diphosphatase	Q2WG49	Clostridium_botulinum_D_phage	2.1e-29	47.3
WP_000691236.1\|60908_61424_+	histidine phosphatase family protein	NA	NA	NA	NA
WP_078065389.1\|61437_62799_+	DNA repair protein RadA	NA	NA	NA	NA
WP_001809263.1\|62871_63369_+	carbonic anhydrase	NA	NA	NA	NA
WP_001844651.1\|63393_63588_+	hypothetical protein	NA	NA	NA	NA
WP_001819301.1\|63569_64193_+\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_000010163.1\|64337_65306_+	ribose-phosphate diphosphokinase	A0A1V0SHF7	Hokovirus	4.0e-44	34.7
WP_000492760.1\|65847_66081_-	hypothetical protein	NA	NA	NA	NA
WP_161801537.1\|66085_66190_-	damage-inducible protein CinA	NA	NA	NA	NA
WP_060544779.1\|66404_66755_-\|transposase	PD-(D/E)XK nuclease family transposase	NA	NA	NA	NA
WP_001844860.1\|67010_69644_+	DNA polymerase I	A0A218MKQ4	uncultured_virus	1.3e-57	30.1
WP_000076480.1\|69728_70166_+	CoA-binding protein	NA	NA	NA	NA
WP_000009173.1\|70528_71539_-	YeiH family putative sulfate export transporter	NA	NA	NA	NA
WP_000366352.1\|71687_72857_+	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_000616164.1\|72853_73624_+	DNA repair protein RecO	NA	NA	NA	NA
WP_000717461.1\|73620_74613_+	phosphate acyltransferase PlsX	NA	NA	NA	NA
WP_000136447.1\|74618_74852_+	acyl carrier protein	A0A2I7RIC8	Vibrio_phage	3.3e-05	40.6
WP_001093075.1\|75390_75621_+\|bacteriocin	bacteriocin-like peptide BlpU	NA	NA	NA	NA
WP_000668301.1\|76335_78489_+	peptide cleavage/export ABC transporter	W8CYL7	Bacillus_phage	5.5e-46	28.2
WP_000801608.1\|78501_79851_+	HlyD family secretion protein	NA	NA	NA	NA
WP_000043300.1\|80020_80728_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D8KNF0	Synechococcus_phage	1.8e-41	39.2
WP_000361197.1\|80929_84655_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	3.3e-38	25.9
WP_000220665.1\|84747_86190_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.2e-54	34.9
WP_000182586.1\|86226_87249_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SE90	Cyanophage	1.6e-64	43.9
WP_000717500.1\|87245_87791_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	4.1e-22	33.9

DBSCAN-SWA_2

139278 : 178739

Planktothrix_phage(25.0%)

tRNA,protease,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001230167.1\|139278_139563_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000723960.1\|139617_141726_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000571037.1\|141722_142364_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	6.7e-24	35.8
WP_001038470.1\|142570_143377_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_114865980.1\|143342_143813_+	argininosuccinate synthase	NA	NA	NA	NA
WP_001189280.1\|144102_144423_-	hypothetical protein	NA	NA	NA	NA
WP_000424422.1\|145186_145567_+\|bacteriocin	SP_0115 family bacteriocin-like peptide	NA	NA	NA	NA
WP_001844753.1\|145940_146999_+	hypothetical protein	NA	NA	NA	NA
WP_000424407.1\|148666_149041_+\|bacteriocin	SPH_0224 family bacteriocin-like peptide	NA	NA	NA	NA
WP_000619752.1\|149248_150151_+	hypothetical protein	NA	NA	NA	NA
WP_000424427.1\|150206_150560_+	hypothetical protein	NA	NA	NA	NA
WP_000072905.1\|150556_151285_+	hypothetical protein	NA	NA	NA	NA
WP_000770316.1\|152416_152656_+	hypothetical protein	NA	NA	NA	NA
WP_000058766.1\|152674_152920_+	hypothetical protein	M1Q0Z8	Streptococcus_phage	1.7e-15	57.6
WP_001035309.1\|153205_155041_+	pneumococcal surface protein A	NA	NA	NA	NA
WP_001282978.1\|155441_156563_+\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_000193606.1\|156703_157159_+	NUDIX hydrolase	NA	NA	NA	NA
WP_000220964.1\|157168_159082_+\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG	NA	NA	NA	NA
WP_000331961.1\|159460_161140_-	ribonuclease J	NA	NA	NA	NA
WP_000639574.1\|161141_161375_-	DNA-dependent RNA polymerase auxiliary subunit epsilon family protein	NA	NA	NA	NA
WP_000977347.1\|162180_162333_-\|bacteriocin	fratricide two-peptide bacteriocin subunit CibB	NA	NA	NA	NA
WP_000180803.1\|162334_162520_-\|bacteriocin	fratricide two-peptide bacteriocin subunit CibA	NA	NA	NA	NA
WP_000865669.1\|162697_163381_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	NA	NA	NA	NA
WP_000569807.1\|163377_163815_+	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_000655036.1\|163804_164815_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	NA	NA	NA	NA
WP_000288029.1\|169591_171208_+	ABC transporter ATP-binding protein	A0A1V0SE00	Indivirus	3.0e-28	36.0
WP_001283046.1\|173651_174401_+	PIG-L family deacetylase	NA	NA	NA	NA
WP_001017606.1\|174413_175586_+	nucleotide sugar dehydrogenase	M1IJ73	Paramecium_bursaria_Chlorella_virus	9.2e-80	43.2
WP_000570712.1\|175980_176844_+	XRE/MutR family transcriptional regulator	NA	NA	NA	NA
WP_000933479.1\|177129_177363_+	hypothetical protein	NA	NA	NA	NA
WP_000738307.1\|177384_178062_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000720788.1\|178073_178739_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_3

325962 : 384344

Streptococcus_phage(23.08%)

transposase,integrase,protease,holin

attL 361451:361464|attR 385268:385281

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001063455.1\|325962_328068_+\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	5.8e-117	37.6
WP_000032550.1\|328922_329405_-	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_000743611.1\|329499_330984_-	DUF1846 domain-containing protein	NA	NA	NA	NA
WP_001156810.1\|331136_332744_+	alpha-glucosidase	NA	NA	NA	NA
WP_001022232.1\|332902_333076_+	hypothetical protein	NA	NA	NA	NA
WP_000091069.1\|335644_337090_+	LCP family protein	A0A1X9I5X1	Streptococcus_phage	3.1e-133	59.9
WP_000565348.1\|337091_337823_+	tyrosine-protein phosphatase CpsB	NA	NA	NA	NA
WP_000664173.1\|337831_338524_+	capsular polysaccharide biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	2.7e-63	56.8
WP_001142516.1\|338533_339199_+	polysaccharide biosynthesis tyrosine autokinase CpsD	A0A1X9I5D6	Streptococcus_phage	1.4e-72	60.7
WP_001053205.1\|339339_340476_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_001079795.1\|340468_341020_+	acyltransferase	NA	NA	NA	NA
WP_000862350.1\|341016_342171_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_000672721.1\|342287_343592_+	oligosaccharide repeat unit polymerase	NA	NA	NA	NA
WP_001818726.1\|343777_344947_+	oligosaccharide flippase family protein	NA	NA	NA	NA
WP_001214397.1\|345014_346085_+	UDP-glucuronate 4-epimerase Gla	A0A291LAD7	Escherichia_phage	7.3e-23	27.6
WP_000685088.1\|346113_347346_+	nucleotide sugar dehydrogenase	M1I6D5	Acanthocystis_turfacea_Chlorella_virus	6.3e-103	49.9
WP_000268343.1\|347561_347744_+	hypothetical protein	NA	NA	NA	NA
WP_000676140.1\|349551_350409_+	glucose-1-phosphate thymidylyltransferase RfbA	K7QKA7	Escherichia_phage	1.7e-94	61.1
WP_000131462.1\|350409_351006_+	dTDP-4-dehydrorhamnose 3,5-epimerase family protein	H9NC63	Sphingomonas_phage	5.1e-10	33.1
WP_000141505.1\|351015_352065_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	8.3e-72	45.1
WP_000927994.1\|353056_353491_+\|transposase	transposase	A0A218MNE7	uncultured_virus	2.1e-05	24.6
WP_000842582.1\|354408_356391_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001032458.1\|356691_361995_+	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
361451:361464	attL	NA	NA	NA	NA
WP_001040012.1\|362161_364321_-	PBP1A family penicillin-binding protein	NA	NA	NA	NA
WP_000248788.1\|364317_364914_-	Holliday junction resolvase RecU	A0A1L2JY30	Aeribacillus_phage	9.6e-17	33.3
WP_000179547.1\|364979_365507_+	DUF1273 domain-containing protein	NA	NA	NA	NA
WP_000146522.1\|365576_365906_+	cell division regulator GpsB	NA	NA	NA	NA
WP_000711391.1\|366391_367549_+	class I SAM-dependent RNA methyltransferase	NA	NA	NA	NA
WP_000039273.1\|367561_368956_+	mid-cell-anchored protein MapZ	NA	NA	NA	NA
WP_000158781.1\|369031_370456_+	NADP-dependent phosphogluconate dehydrogenase	M4QQM4	Ostreococcus_lucimarinus_virus	1.6e-41	29.6
WP_000518018.1\|370467_371157_+	response regulator transcription factor	NA	NA	NA	NA
WP_000771110.1\|371254_372274_+\|holin	choline-binding protein CbpC	NA	NA	NA	NA
WP_000765670.1\|372391_373624_-	MFS transporter	NA	NA	NA	NA
WP_001844742.1\|373783_374254_-	hypothetical protein	NA	NA	NA	NA
WP_179130704.1\|374420_374831_-	hypothetical protein	NA	NA	NA	NA
WP_000206971.1\|375361_375484_+\|holin	choline-binding protein C	NA	NA	NA	NA
WP_000163315.1\|375605_376484_+	mevalonate kinase	NA	NA	NA	NA
WP_000373458.1\|376465_377419_+	diphosphomevalonate decarboxylase	NA	NA	NA	NA
WP_000562430.1\|377405_378413_+	phosphomevalonate kinase	NA	NA	NA	NA
WP_000210617.1\|378396_379407_+	type 2 isopentenyl-diphosphate Delta-isomerase	NA	NA	NA	NA
WP_001224637.1\|379483_380182_+	cell wall-active antibiotics response protein	NA	NA	NA	NA
WP_000743661.1\|380178_381174_+	sensor histidine kinase	NA	NA	NA	NA
WP_000698434.1\|381187_381820_+	response regulator transcription factor	NA	NA	NA	NA
WP_001808881.1\|381820_382063_+	DNA alkylation repair protein	NA	NA	NA	NA
WP_075588398.1\|381987_382299_+	DNA alkylation repair protein	NA	NA	NA	NA
WP_000754501.1\|382739_382979_+	hypothetical protein	NA	NA	NA	NA
WP_001844741.1\|383023_383653_+\|protease	serine protease	NA	NA	NA	NA
WP_000378125.1\|383951_384344_+\|integrase	tyrosine-type recombinase/integrase	C9E2L6	Enterococcus_phage	3.6e-20	41.4
385268:385281	attR	NA	NA	NA	NA

DBSCAN-SWA_4

442283 : 505027

Klosneuvirus(16.67%)

tRNA,transposase,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001808894.1\|442283_442454_-\|transposase	transposase	NA	NA	NA	NA
WP_000628994.1\|443276_444500_-	ROK family transcriptional regulator	NA	NA	NA	NA
WP_001059639.1\|444667_445990_+	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_000236919.1\|445991_447878_+	DUF4838 domain-containing protein	NA	NA	NA	NA
WP_000836780.1\|448045_448390_+	PTS lactose/cellobiose transporter subunit IIA	NA	NA	NA	NA
WP_000429426.1\|448399_449812_+	6-phospho-beta-galactosidase	NA	NA	NA	NA
WP_000359734.1\|449881_451561_+	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_001845061.1\|451686_453126_-	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000691674.1\|453129_454479_-	Trk system potassium transporter TrkA	NA	NA	NA	NA
WP_001063601.1\|454666_455515_+	S-adenosyl-l-methionine hydroxide adenosyltransferase family protein	NA	NA	NA	NA
WP_000403162.1\|455529_456078_+	ECF-type riboflavin transporter substrate-binding protein	NA	NA	NA	NA
WP_000693286.1\|456084_456342_+	hypothetical protein	NA	NA	NA	NA
WP_000656547.1\|456443_458126_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	7.7e-19	34.4
WP_001148103.1\|458110_458941_+	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_000181374.1\|459133_459637_+\|tRNA	tRNA (cytidine(34)-2'-O)-methyltransferase	NA	NA	NA	NA
WP_000185835.1\|460089_460653_+	ECF transporter S component	NA	NA	NA	NA
WP_000678693.1\|460666_461293_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_000867290.1\|461320_461710_+	chromosome partitioning protein ParB	NA	NA	NA	NA
WP_000333653.1\|461714_462164_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000418402.1\|462291_462879_+	DNA-directed RNA polymerase subunit delta	NA	NA	NA	NA
WP_000105242.1\|463268_464876_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	8.9e-142	47.0
WP_000026645.1\|465434_467066_-	Na/Pi cotransporter family protein	NA	NA	NA	NA
WP_000795217.1\|467358_472299_+	bacterial Ig-like domain-containing protein	NA	NA	NA	NA
WP_001096743.1\|472388_473585_+	phosphoglycerate kinase	NA	NA	NA	NA
WP_000119905.1\|473720_474248_+	aromatic acid exporter family protein	NA	NA	NA	NA
WP_000659547.1\|474324_474681_+	transcriptional repressor GlnR	NA	NA	NA	NA
WP_001122900.1\|474717_476064_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_001808898.1\|476153_476273_-	hypothetical protein	NA	NA	NA	NA
WP_001845060.1\|476506_477853_-\|transposase	IS1380-like element ISSpn5 family transposase	A0A1X9I6F6	Streptococcus_phage	1.3e-77	40.0
WP_001220758.1\|478546_479827_+	restriction endonuclease subunit S	A0A1V0SKS6	Klosneuvirus	6.9e-12	29.2
WP_000651177.1\|479883_480681_+	tyrosine-type DNA invertase PsrA	A0A0H4TI16	Erysipelothrix_phage	1.3e-21	28.7
WP_001813510.1\|480691_481297_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_000187276.1\|481244_482795_-	restriction endonuclease subunit S	A0A1V0SLK8	Klosneuvirus	9.9e-13	25.6
WP_000029046.1\|482794_484258_-	SAM-dependent DNA methyltransferase	NA	NA	NA	NA
WP_000856786.1\|484270_486109_-	DEAD/DEAH box helicase family protein	A0A097BY72	Enterococcus_phage	1.6e-25	26.3
WP_001088691.1\|487211_487721_+	DUF2812 domain-containing protein	NA	NA	NA	NA
WP_000255779.1\|487884_488919_+	heat-inducible transcriptional repressor HrcA	NA	NA	NA	NA
WP_000046031.1\|488945_489470_+	nucleotide exchange factor GrpE	NA	NA	NA	NA
WP_000034662.1\|489949_491773_+	molecular chaperone DnaK	A0A0N9QXN8	Chrysochromulina_ericina_virus	1.3e-133	47.2
WP_000115730.1\|491785_492139_+	hypothetical protein	NA	NA	NA	NA
WP_001836079.1\|492343_493480_+	molecular chaperone DnaJ	E3T4P7	Cafeteria_roenbergensis_virus	2.4e-24	31.3
WP_001845059.1\|493801_494176_-	hypothetical protein	NA	NA	NA	NA
WP_000777760.1\|494337_494625_-	hypothetical protein	NA	NA	NA	NA
WP_001278301.1\|494634_495045_-	HIT family protein	B5LJ12	Mycobacterium_phage	3.4e-05	31.6
WP_000889923.1\|495112_495844_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	9.0e-25	28.6
WP_000653769.1\|495840_496890_+	ABC transporter permease	NA	NA	NA	NA
WP_000132583.1\|497057_497387_-	hypothetical protein	NA	NA	NA	NA
WP_000682136.1\|497663_498002_+	response regulator transcription factor	NA	NA	NA	NA
WP_001219137.1\|498006_498744_+	response regulator transcription factor	NA	NA	NA	NA
WP_001099894.1\|498757_500098_+	sensor histidine kinase	NA	NA	NA	NA
WP_000358812.1\|500141_500297_-	quorum-sensing system pheromone BlpC	NA	NA	NA	NA
WP_001069063.1\|500353_501715_-\|bacteriocin	bacteriocin secretion accessory protein	NA	NA	NA	NA
WP_000205160.1\|501725_503879_-	peptide cleavage/export ABC transporter BlpA	W8CYL7	Bacillus_phage	2.4e-41	27.7
WP_001093255.1\|504160_504415_+\|bacteriocin	two-peptide bacteriocin subunit BlpM	NA	NA	NA	NA
WP_001099490.1\|504430_504634_+\|bacteriocin	two-peptide bacteriocin subunit BlpN	NA	NA	NA	NA
WP_001809846.1\|504877_505027_+\|bacteriocin	bacteriocin-like peptide BlpO	NA	NA	NA	NA

DBSCAN-SWA_5

860376 : 870018

Streptococcus_phage(88.89%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000728264.1\|860376_862260_+\|holin	phosphorylcholine esterase CbpE	Q332B9	Clostridium_botulinum_C_phage	9.5e-10	23.7
WP_001844793.1\|862339_863470_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.1e-114	58.4
WP_000254688.1\|863479_864742_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	2.3e-140	65.0
WP_000689700.1\|864745_865543_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	1.1e-60	50.9
WP_000033388.1\|865762_866401_+	dTMP kinase	M1PSC7	Streptococcus_phage	2.9e-75	67.6
WP_000806708.1\|866397_867288_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	6.4e-73	51.4
WP_000358228.1\|867327_867645_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	2.9e-28	60.0
WP_001166878.1\|867647_868517_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	2.3e-115	75.7
WP_001261452.1\|868743_869262_+	ClbS/DfsB family four-helix bundle protein	NA	NA	NA	NA
WP_000345254.1\|869370_870018_+	replication initiator protein A	A0A2P0VK56	Streptococcus_phage	7.0e-13	33.7

DBSCAN-SWA_6

1065577 : 1086280

Streptococcus_phage(94.74%)

integrase,protease

attL 1056062:1056077|attR 1076871:1076886

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1056062:1056077	attL	NA	NA	NA	NA
WP_001210976.1\|1065577_1066936_+	DNA (cytosine-5-)-methyltransferase	A0A141E1L1	Streptococcus_phage	1.3e-130	56.7
WP_000645900.1\|1066919_1067369_+	hypothetical protein	NA	NA	NA	NA
WP_000566528.1\|1067361_1067742_+	hypothetical protein	NA	NA	NA	NA
WP_000840776.1\|1067754_1067988_+	hypothetical protein	NA	NA	NA	NA
WP_000821271.1\|1067990_1068593_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001291561.1\|1068754_1069972_-\|integrase	tyrosine-type recombinase/integrase	A0A1S5SEW7	Streptococcus_phage	3.7e-233	100.0
WP_000814511.1\|1070053_1070257_-	excisionase	A0A1S5SF07	Streptococcus_phage	4.0e-31	100.0
WP_000857133.1\|1070717_1070948_-	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	2.7e-36	100.0
WP_000804885.1\|1070944_1071367_-	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	2.5e-72	100.0
WP_001227347.1\|1071871_1072225_+	helix-turn-helix domain-containing protein	A0A1S5SFA6	Streptococcus_phage	1.3e-58	100.0
WP_000336323.1\|1072284_1072452_-	cysteine-rich KTR domain-containing protein	D0R0F6	Streptococcus_phage	1.6e-14	68.0
WP_000691751.1\|1072570_1074490_-	tetracycline resistance ribosomal protection protein Tet(M)	A0A2K5B2A5	Erysipelothrix_phage	0.0e+00	99.5
WP_001814923.1\|1074505_1074622_-	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_001224320.1\|1074866_1075802_-	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	7.7e-170	99.0
WP_000769868.1\|1075798_1076800_-	lysozyme family protein	A0A1S5SEZ8	Streptococcus_phage	5.0e-191	100.0
WP_000804748.1\|1076796_1078974_-	membrane protein	A0A1S5SF30	Streptococcus_phage	0.0e+00	100.0
1076871:1076886	attR	NA	NA	NA	NA
WP_000331160.1\|1078976_1081424_-	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	100.0
WP_000506269.1\|1081407_1081914_-	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	9.5e-90	99.4
WP_000342539.1\|1081888_1082386_-	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.7e-91	100.0
WP_001009056.1\|1082502_1082724_-	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.3e-31	100.0
WP_000398284.1\|1082766_1083972_-	replication initiation factor domain-containing protein	A0A1S5SEX3	Streptococcus_phage	2.8e-233	100.0
WP_000879507.1\|1083994_1084147_-	hypothetical protein	NA	NA	NA	NA
WP_000813485.1\|1084149_1085535_-	DNA translocase FtsK	A0A1S5SFB5	Streptococcus_phage	1.2e-264	99.8
WP_000985015.1\|1085563_1085950_-	YdcP family protein	A0A1S5SF96	Streptococcus_phage	3.0e-64	100.0
WP_000420682.1\|1085965_1086280_-	YdcP family protein	A0A1S5SF38	Streptococcus_phage	5.2e-54	100.0

DBSCAN-SWA_7

1193329 : 1259809

Indivirus(16.67%)

transposase,protease,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000792121.1\|1193329_1194283_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000726272.1\|1194455_1196621_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_001096339.1\|1196620_1197361_+	amino acid ABC transporter ATP-binding protein	W5SAS9	Pithovirus	4.9e-18	27.5
WP_000096168.1\|1197509_1198997_+	glucose-6-phosphate dehydrogenase	H6WFS4	Cyanophage	4.9e-70	32.8
WP_000522311.1\|1199040_1200330_-	signal recognition particle-docking protein FtsY	NA	NA	NA	NA
WP_000763468.1\|1200333_1201152_-	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_000153021.1\|1201151_1201946_-	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_000280946.1\|1201942_1205482_-	chromosome segregation protein SMC	NA	NA	NA	NA
WP_000661496.1\|1205472_1206171_-	ribonuclease III	J2YAN1	Acanthamoeba_polyphaga_lentillevirus	2.5e-24	32.9
WP_000931157.1\|1206488_1207475_-	GMP reductase	G3MBI2	Bacillus_virus	2.4e-137	72.2
WP_001223088.1\|1207649_1208966_-	McrC family protein	NA	NA	NA	NA
WP_001042395.1\|1208952_1210866_-	McrB family protein	K4I1H4	Acidithiobacillus_phage	1.8e-16	33.7
WP_001867136.1\|1211814_1212174_-	3-isopropylmalate dehydratase small subunit	NA	NA	NA	NA
WP_000762426.1\|1212177_1212447_-	DUF1294 domain-containing protein	NA	NA	NA	NA
WP_001074712.1\|1212443_1213481_-	3-isopropylmalate dehydrogenase	NA	NA	NA	NA
WP_000461585.1\|1214605_1215262_-	MmcQ/YjbR family DNA-binding protein	NA	NA	NA	NA
WP_000638796.1\|1215305_1215938_-	copper homeostasis protein CutC	NA	NA	NA	NA
WP_001237219.1\|1216030_1216390_-	YbaN family protein	NA	NA	NA	NA
WP_000179635.1\|1216495_1218583_-	type I DNA topoisomerase	A0A1V0SCS0	Indivirus	3.0e-105	37.6
WP_012677071.1\|1218749_1219793_-	TIGR00341 family protein	NA	NA	NA	NA
WP_000705306.1\|1220676_1221525_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	4.2e-34	39.5
WP_000643975.1\|1221622_1222312_-	NTP transferase domain-containing protein	A0A127AW70	Bacillus_phage	3.4e-05	45.0
WP_000837609.1\|1222323_1223202_-	DMT family transporter	NA	NA	NA	NA
WP_000411229.1\|1223191_1224061_-\|holin	choline kinase LicA	NA	NA	NA	NA
WP_000609894.1\|1224077_1225100_-	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_000638502.1\|1225104_1225812_-	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_000835899.1\|1226147_1227635_+	type IV teichoic acid flippase TacF	NA	NA	NA	NA
WP_000811874.1\|1227644_1228448_+\|holin	phosphorylcholine transferase LicD	A0A1V0SD50	Indivirus	5.3e-10	27.1
WP_001199649.1\|1228449_1229259_+\|holin	phosphorylcholine transferase LicD	A0A1V0SD50	Indivirus	9.1e-10	30.3
WP_001126437.1\|1229533_1232710_-	carbamoyl-phosphate synthase large subunit	NA	NA	NA	NA
WP_000166703.1\|1233022_1234102_-	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	2.2e-59	36.2
WP_001293845.1\|1234151_1235075_-	aspartate carbamoyltransferase catalytic subunit	M1HGA5	Paramecium_bursaria_Chlorella_virus	8.7e-25	31.7
WP_000850024.1\|1235093_1235615_-	bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR	NA	NA	NA	NA
WP_000244451.1\|1235825_1236455_-	endonuclease III	NA	NA	NA	NA
WP_000773235.1\|1236454_1236997_-	DUF177 domain-containing protein	NA	NA	NA	NA
WP_001844621.1\|1237721_1239281_+	ABC-F family ATP-binding cassette domain-containing protein	A0A1B0RXA0	Streptococcus_phage	2.1e-10	27.5
WP_000895728.1\|1239324_1240224_-\|protease	zinc metalloprotease HtpX	NA	NA	NA	NA
WP_000219823.1\|1240225_1240786_-	LemA family protein	NA	NA	NA	NA
WP_000801941.1\|1240879_1241593_+	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	NA	NA	NA	NA
WP_000808288.1\|1241846_1243130_+	uracil transporter	Q9KX94	Enterobacteria_phage	4.0e-60	35.3
WP_000863631.1\|1243324_1244896_-	signal recognition particle protein	NA	NA	NA	NA
WP_000402071.1\|1244907_1245240_-	putative DNA-binding protein	NA	NA	NA	NA
WP_001814693.1\|1245330_1245708_-	DUF1934 domain-containing protein	NA	NA	NA	NA
WP_001003469.1\|1245779_1247084_+	HD domain-containing protein	E3T4P8	Cafeteria_roenbergensis_virus	1.7e-26	30.5
WP_000023524.1\|1247096_1247903_+	sugar-phosphatase	NA	NA	NA	NA
WP_001009007.1\|1247945_1248944_+	SAP domain-containing protein	NA	NA	NA	NA
WP_001068669.1\|1249222_1249570_-	50S ribosomal protein L19	NA	NA	NA	NA
WP_000237418.1\|1249688_1250018_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	8.2e-10	37.8
WP_000712098.1\|1250011_1250386_-	fluoride efflux transporter CrcB	NA	NA	NA	NA
WP_000362438.1\|1250382_1250649_-	chorismate mutase	NA	NA	NA	NA
WP_001162129.1\|1250764_1251208_-	flavodoxin	NA	NA	NA	NA
WP_000401777.1\|1251311_1252247_+	bifunctional oligoribonuclease/PAP phosphatase NrnA	NA	NA	NA	NA
WP_001808393.1\|1252300_1252585_+	type B 50S ribosomal protein L31	NA	NA	NA	NA
WP_000252109.1\|1252641_1253220_-	hypothetical protein	NA	NA	NA	NA
WP_000199558.1\|1255197_1256544_+	NADP-specific glutamate dehydrogenase	NA	NA	NA	NA
WP_000711943.1\|1257039_1257210_-	hypothetical protein	NA	NA	NA	NA
WP_000151483.1\|1257222_1257864_-	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	1.7e-19	40.1
WP_001845280.1\|1258462_1259809_-\|transposase	IS1380-like element ISSpn5 family transposase	A0A1X9I6F6	Streptococcus_phage	1.7e-77	39.8

DBSCAN-SWA_8

1363243 : 1406224

Streptococcus_phage(28.57%)

tRNA,transposase,bacteriocin,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000691855.1\|1363243_1363438_-\|transposase	transposase	NA	NA	NA	NA
WP_001136122.1\|1363938_1364124_-	hypothetical protein	NA	NA	NA	NA
WP_000065693.1\|1364427_1365990_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	1.4e-19	32.8
WP_000936184.1\|1366131_1366830_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000071665.1\|1366872_1367769_-	EamA family transporter	NA	NA	NA	NA
WP_000872220.1\|1367777_1368713_-	serine hydrolase	NA	NA	NA	NA
WP_001102217.1\|1368709_1369435_-	CppA family protein	NA	NA	NA	NA
WP_000290648.1\|1369518_1370154_-\|holin	1-alkyl-2-acetylglycerophosphocholine esterase	A0A2K9L661	Tupanvirus	4.3e-07	28.2
WP_000972931.1\|1370155_1370983_-	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_000526284.1\|1371004_1371340_-	hypothetical protein	NA	NA	NA	NA
WP_001272941.1\|1372502_1373114_+	peptide deformylase	E3SLL2	Synechococcus_phage	4.9e-16	42.4
WP_000855733.1\|1373158_1373887_+	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_000272302.1\|1373925_1374837_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	4.5e-90	51.8
WP_000926600.1\|1374902_1375127_-	DUF4059 family protein	NA	NA	NA	NA
WP_000590986.1\|1375204_1375948_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.6e-29	41.0
WP_001103449.1\|1375947_1376748_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_000889093.1\|1376905_1377262_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.2e-33	57.3
WP_001170346.1\|1377274_1377787_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.3e-46	55.6
WP_000405821.1\|1377786_1378281_-	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	2.9e-43	52.8
WP_000858735.1\|1378415_1378862_+	DUF1836 domain-containing protein	NA	NA	NA	NA
WP_001097986.1\|1378858_1379506_+	hemolysin III family protein	NA	NA	NA	NA
WP_000689945.1\|1379526_1380108_-	pyridoxal 5'-phosphate synthase glutaminase subunit PdxT	NA	NA	NA	NA
WP_000138517.1\|1380108_1380984_-	pyridoxal 5'-phosphate synthase lyase subunit PdxS	NA	NA	NA	NA
WP_000036789.1\|1381135_1382515_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_000175407.1\|1382808_1383732_+	FAD:protein FMN transferase	NA	NA	NA	NA
WP_000915957.1\|1383791_1384397_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	7.7e-54	54.2
WP_000673694.1\|1384415_1385660_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL82	Lactobacillus_phage	1.7e-55	52.7
WP_000371293.1\|1385882_1386140_-	DUF896 family protein	NA	NA	NA	NA
WP_000164760.1\|1386181_1388218_-\|tRNA	glycine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_000038731.1\|1388477_1389395_-\|tRNA	glycine--tRNA ligase subunit alpha	NA	NA	NA	NA
WP_012677106.1\|1389763_1390090_-	hypothetical protein	NA	NA	NA	NA
WP_001846081.1\|1390056_1390341_-	hypothetical protein	NA	NA	NA	NA
WP_001099682.1\|1390613_1391456_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	2.2e-51	40.2
WP_001844203.1\|1391569_1392961_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_001813436.1\|1393195_1393573_-\|transposase	PD-(D/E)XK nuclease family transposase	NA	NA	NA	NA
WP_000915901.1\|1393787_1394765_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_000850587.1\|1394761_1395844_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	5.2e-37	31.0
WP_001040724.1\|1397337_1398534_-	elongation factor Tu	A0A076FFS6	Aureococcus_anophage	7.3e-32	29.6
WP_000348122.1\|1399409_1400279_-	aquaporin family protein	NA	NA	NA	NA
WP_000248973.1\|1400501_1401182_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_001021429.1\|1401139_1402246_-	MucBP domain-containing protein	NA	NA	NA	NA
WP_012677083.1\|1402181_1402379_-	hypothetical protein	NA	NA	NA	NA
WP_001833808.1\|1402356_1402611_-	hypothetical protein	NA	NA	NA	NA
WP_000200313.1\|1402968_1403502_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_001844799.1\|1403488_1403704_-	hypothetical protein	NA	NA	NA	NA
WP_001833809.1\|1403670_1403814_-\|transposase	transposase	NA	NA	NA	NA
WP_000121713.1\|1404047_1405766_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	1.5e-272	83.4
WP_000434652.1\|1405876_1406224_+\|bacteriocin	PedC/BrcD family bacteriocin maturation disulfide isomerase	NA	NA	NA	NA

DBSCAN-SWA_9

1469244 : 1475998

Streptococcus_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000081003.1\|1469244_1470213_+	NAD(P)/FAD-dependent oxidoreductase	Q9JRK7	Streptococcus_phage	2.8e-66	100.0
WP_000011276.1\|1470246_1471158_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	2.3e-155	100.0
WP_001231093.1\|1471154_1472132_-	YvcK family protein	A1IMD5	Streptococcus_phage	9.8e-184	99.4
WP_000163033.1\|1472128_1473019_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	3.9e-06	29.8
WP_001140412.1\|1473070_1473451_-	RidA family protein	NA	NA	NA	NA
WP_000422409.1\|1473461_1474049_-	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_000106346.1\|1474057_1475290_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	4.2e-131	59.0
WP_000162483.1\|1475491_1475998_-	dihydrofolate reductase	G3MBI7	Bacillus_virus	6.7e-27	42.5

DBSCAN-SWA_10

1735291 : 1742623

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000167850.1\|1735291_1735993_+	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	4.1e-35	36.5
WP_000777244.1\|1736415_1737375_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	2.4e-57	40.8
WP_001193668.1\|1737364_1738321_+	iron chelate uptake ABC transporter family permease subunit	NA	NA	NA	NA
WP_000764304.1\|1738317_1739070_+	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	5.6e-14	28.1
WP_000858260.1\|1739165_1740131_+	siderophore ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000821643.1\|1740355_1740598_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	1.7e-17	59.4
WP_001222225.1\|1740597_1741320_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_000105310.1\|1741306_1741876_-	segregation/condensation protein B	A0A1B1IVT7	uncultured_Mediterranean_phage	5.0e-15	34.9
WP_000351907.1\|1741894_1742623_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	5.3e-09	22.3

DBSCAN-SWA_11

2089735 : 2098489

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000510406.1\|2089735_2090575_-	energy-coupling factor transporter ATPase	W8CYL7	Bacillus_phage	1.5e-15	32.6
WP_000835715.1\|2090559_2091387_-	energy-coupling factor transporter ATPase	W8CYL7	Bacillus_phage	3.5e-17	33.3
WP_000712132.1\|2091383_2091929_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_001227958.1\|2091939_2092761_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_000170194.1\|2092802_2094086_-	insulinase family protein	A0A1E1EST3	Acanthamoeba_castellanii_mimivirus	1.1e-17	30.0
WP_000424262.1\|2094082_2095333_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	2.7e-93	42.3
WP_000455903.1\|2095491_2095860_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	7.0e-18	57.3
WP_000266662.1\|2095862_2096960_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_000073428.1\|2097010_2098489_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	2.2e-94	40.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_012467

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection