CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_012469	Streptococcus pneumoniae Taiwan19F-14, complete genome	2 crisprs	DEDDh,cas3,DinG	0	1	12	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_012469_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012469_1

1081776-1081879

Orphan

Consensus_repeat	Method
ATAGGGGATTTACCCACTACAAATATTATAGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012469_1

>merge|NC_012469|1|1081776-1081879|CRISPRCasFinder
ATAGGGGATTTACCCACTACAAATATTATAGAGCCCTTTTTTTCTACAATAAAATAGGCTCCATAATATCTATAGTGGATTTACCCACTACAAATATTATAGAG

>NC_012469|1|1|1081776-1081879|CRISPRCasFinder
ATAGGGGATTTACCCACTACAAATATTATAGAG	CCCTTTTTTTCTACAATAAAATAGGCTCCATAATATCT
ATAGTGGATTTACCCACTACAAATATTATAGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012469.1\|WP_000799053.1\|1077316_1078135_+\|NAD-kinase	unknown	unknown	gnl\|CDD\|235317
NC_012469.1\|WP_000653403.1\|1072468_1073110_-\|redox-sensing-transcriptional-repressor-Rex	unknown	unknown	gnl\|CDD\|225221
NC_012469.1\|WP_000639664.1\|1073767_1074883_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_012469.1\|WP_000171676.1\|1076661_1077333_+\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232
NC_012469.1\|WP_001283813.1\|1074892_1075852_-\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|235039
NC_012469.1\|WP_000584888.1\|1089005_1090907_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_012469.1\|WP_000981526.1\|1081938_1082238_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NC_012469.1\|WP_000109141.1\|1083525_1083840_+\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NC_012469.1\|WP_010963271.1\|1073192_1073444_-\|DUF4649-family-protein	unknown	unknown	gnl\|CDD\|339492
NC_012469.1\|WP_000592056.1\|1086367_1087216_-\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NC_012469.1\|WP_000613700.1\|1083855_1084200_+\|ribosomal-processing-cysteine-protease-Prp	unknown	unknown	gnl\|CDD\|225423
NC_012469.1\|WP_001284639.1\|1088303_1088579_+\|HU-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|259853
NC_012469.1\|WP_000587444.1\|1085357_1086275_+\|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl\|CDD\|235536
NC_012469.1\|WP_001210006.1\|1078131_1079028_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_012469.1\|WP_000451584.1\|1079071_1080046_+\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|236609
NC_012469.1\|WP_000509041.1\|1082639_1083338_+\|DUF1275-domain-containing-protein	unknown	unknown	gnl\|CDD\|226146
NC_012469.1\|WP_000916509.1\|1084216_1084510_+\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NC_012469.1\|WP_000161392.1\|1087357_1088197_+\|DegV-family-protein	unknown	unknown	gnl\|CDD\|273257
NC_012469.1\|WP_000681293.1\|1075964_1076534_-\|CYTH-domain-containing-protein	unknown	unknown	gnl\|CDD\|226601
NC_012469.1\|WP_000863509.1\|1073415_1073763_-\|DUF1831-domain-containing-protein	unknown	unknown	gnl\|CDD\|370163

Protein	Function_ID	Function_description	E-value
NC_012469.1\|WP_000799053.1\|1077316_1078135_+\|NAD-kinase	gnl\|CDD\|235317	PRK04885, ppnK, inorganic polyphosphate/ATP-NAD kinase; Provisional.	9.83191e-171
NC_012469.1\|WP_000653403.1\|1072468_1073110_-\|redox-sensing-transcriptional-repressor-Rex	gnl\|CDD\|225221	COG2344, COG2344, AT-rich DNA-binding protein [General function prediction only].	1.79308e-117
NC_012469.1\|WP_000639664.1\|1073767_1074883_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	4.06104e-174
NC_012469.1\|WP_000171676.1\|1076661_1077333_+\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	7.7772e-102
NC_012469.1\|WP_001283813.1\|1074892_1075852_-\|ribose-phosphate-diphosphokinase	gnl\|CDD\|235039	PRK02458, PRK02458, ribose-phosphate pyrophosphokinase; Provisional.	0
NC_012469.1\|WP_000584888.1\|1089005_1090907_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0
NC_012469.1\|WP_000981526.1\|1081938_1082238_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	1.2452e-33
NC_012469.1\|WP_000109141.1\|1083525_1083840_+\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	6.1021e-45
NC_012469.1\|WP_010963271.1\|1073192_1073444_-\|DUF4649-family-protein	gnl\|CDD\|339492	pfam15507, DUF4649, Domain of unknown function (DUF4649). This family of Firmicute sequences has members that are annotated as ribose-phosphate pyrophosphokinase; however there is no evidence for this attribution. Member proteins are all shorter than 100 residues in length.	2.08879e-28
NC_012469.1\|WP_000592056.1\|1086367_1087216_-\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	4.30505e-85
NC_012469.1\|WP_000613700.1\|1083855_1084200_+\|ribosomal-processing-cysteine-protease-Prp	gnl\|CDD\|225423	COG2868, COG2868, Predicted ribosomal protein [Translation, ribosomal structure and biogenesis].	4.93617e-39
NC_012469.1\|WP_001284639.1\|1088303_1088579_+\|HU-family-DNA-binding-protein	gnl\|CDD\|259853	cd13831, HU, histone-like DNA-binding protein HU. This subfamily includes HU and HU-like domains. HU is a conserved nucleoid-associated protein (NAP) which binds non-specifically to duplex DNA with a particular preference for targeting nicked and bent DNA. It is highly basic and contributes to chromosomal compaction and maintenance of negative supercoiling, thus often referred to as histone-like protein. HU can induce DNA bends, condense DNA in a fiber and also interact with single stranded DNA. It contains two homologous subunits, alpha and beta, typically forming homodimers (alpha-alpha and beta-beta), except in E. coli and other enterobacteria, which form heterodimers (alpha-beta). In E. coli, HU binds uniformly to the chromosome, with a preference for damaged or distorted DNA structures and can introduce negative supercoils into closed circular DNA in the presence of topoisomerase I. Anabaena HU (AHU) shows preference for A/T-rich region in the center of its DNA binding site.	4.4762e-40
NC_012469.1\|WP_000587444.1\|1085357_1086275_+\|bifunctional-riboflavin-kinase/FAD-synthetase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	8.98101e-130
NC_012469.1\|WP_001210006.1\|1078131_1079028_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	8.56983e-100
NC_012469.1\|WP_000451584.1\|1079071_1080046_+\|phosphate-acetyltransferase	gnl\|CDD\|236609	PRK09653, eutD, phosphotransacetylase.	0
NC_012469.1\|WP_000509041.1\|1082639_1083338_+\|DUF1275-domain-containing-protein	gnl\|CDD\|226146	COG3619, COG3619, Predicted membrane protein [Function unknown].	8.49808e-63
NC_012469.1\|WP_000916509.1\|1084216_1084510_+\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	6.08512e-51
NC_012469.1\|WP_000161392.1\|1087357_1088197_+\|DegV-family-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	3.43566e-110
NC_012469.1\|WP_000681293.1\|1075964_1076534_-\|CYTH-domain-containing-protein	gnl\|CDD\|226601	COG4116, COG4116, Uncharacterized protein conserved in bacteria [Function unknown].	1.98141e-96
NC_012469.1\|WP_000863509.1\|1073415_1073763_-\|DUF1831-domain-containing-protein	gnl\|CDD\|370163	pfam08866, DUF1831, Putative amino acid metabolism. Solution of the structure of the Lactobacillus plantarum protein from this family has indicated a potential new fold with remote similarities to TBP-like (TATA-binding protein) structures. This similarity, in combination with genomic context analysis, leads us to propose an involvement in amino-acid metabolism. The potentially novel fold is an alpha + beta fold comprising two beta sheets packed against a single helix. The enzyme is present in the cytosol.	7.32693e-51

>NC_012469.1|WP_000451584.1|1079071_1080046_+|phosphate-acetyltransferase
MEVFESLKANLVGKNARIVLPEGEEPRILQATKRLVKETEVIPVLLGNPEKIKIYLEIEGIMDGYEVIDPQHYPQFEEMVSALVERRKGKMTEEDVRKVLVEDVNYFGVMLVYLGLVDGMVSGAIHSTASTVRPALQIIKTRPNVTRTSGAFLMVRGTERYLFGDCAININPDAEALAEIAINSAITAKMFGIEPKIAMLSYSTKGSGFGESVDKVVEATKIAHDLRPDLEIDGELQFDAAFVPETAALKAPGSTVAGQANVFIFPGIEAGNIGYKMAERLGGFAAVGPVLQGLNKPVNDLSRGCNADDVYKLTLITAAQAVHQ
>NC_012469.1|WP_001210006.1|1078131_1079028_+|RluA-family-pseudouridine-synthase
MRFEFIADEHVKVKTFLKKHEVSKGLLAKIKFRGGAILVNNQPQNATYLLDVGDYVTIDIPAEKGFETLEAIELPLDILYEDDHFLVLNKPYGVASIPSVNHSNTIANFIKGYYVKQNYENQQVHIVTRLDRDTSGLMLFAKHGYAHARLDKQLQKKSIEKRYFALVKGDGHLEPEGEIIAPIARDEDSIITRRVAKGGKYAHTSYKIVASYGNIHLVDIRLHTGRTHQIRVHFSHIGFPLLGDDLYGGSLDDGIQRQALHCHYLSFYHPFLEQDLQLESPLPDDFSNLITQLSTNTL
>NC_012469.1|WP_000799053.1|1077316_1078135_+|NAD-kinase
MKNTGKRIDLIANRKPQSQRVLYELRDRLKRNQFILNDTNPDIVISIGGDGMLLSAFHKYENQLDKVRFIGLHTGHLGFYTDYRDFELDKLVTNLQLDTGARVSYPVLNVKVFLENGEVKIFRALNEASIRRSDRTMVADIVINGVPFERFRGDGLTVSTPTGSTAYNKSLGGAVLHPTIEALQLTEIASLNNRVYRTLGSSIIVPKKDKIELIPTRNDYHTISVDNSVYSFRNIERIEYQIDHHKIHFVATPSHTSFWNRVKDAFIGEVDE
>NC_012469.1|WP_000171676.1|1076661_1077333_+|GTP-pyrophosphokinase-family-protein
MTLEWEEFLDPYIQAVGELKIKLRGIRKQYRKQNKHSPIEFVTGRVKPIESIKEKMARRGITYATLEHDLQDIAGLRVMVQFVDDVKEVVDILHKRQDMRIIQERDYITHRKASGYRSYHVVVEYTVDTINGAKTILAEIQIRTLAMNFWATIEHSLNYKYQGDFPDEIKKRLEITARIAHQLDEEMGEIRDDIQEAQALFDPLSRKLNDGVGNSDDTDEEYR
>NC_012469.1|WP_000681293.1|1075964_1076534_-|CYTH-domain-containing-protein
MKHLEIELKTLLKKDEYNRLKDQFTGVTPVLQTNYYIDTPDFELREKKVAMRIRTFEDWAELTLKVPQSVGNMEYNQKLQLKDAENYLSKEELPQGLVLDELAKHGIQSKNWQVLGCLTTLRYEMKTAIGLMALDQSRYFDMTDYELELEVENHEQGKQDFRQFLEKNQISYQKAPSKLVRFVKSMKNS
>NC_012469.1|WP_001283813.1|1074892_1075852_-|ribose-phosphate-diphosphokinase
MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAHSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCDKGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGYIIGDVEGKKAILIDDILNTGRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNKKK
>NC_012469.1|WP_000639664.1|1073767_1074883_-|cysteine-desulfurase
MIYLDNAATTPMSAVAISAMTKVMQETHGNPSSIHGHGRQAGKLLREARQELAQLLRTKPQHIFFTSGGTEGNNTTIIGYCLRHQEQGKHIITTAIEHHAVLETIDYLVQHFGFEATIIQPENQEITAQQIQKALRDDTILVSTMFANNETGNLLPIAEIGQILKQHPAAYHVDAVQAIGKIPIHSEELGIDFLTASAHKFHGPKGIGFLYASSMDFDSYLHGGDQEQKKRAGTENLPAIVGMVAALKEDLEKQEEHFQHVQNLETAFLAELEGIQYYLNRGKHHLPYVLNIGFPGQKNDLLLLRLDLAGISISTGSACTAGVVQSSHVLKAMYGANSERLKESLRISLSPQNTVEDLQTLAKTLKEIIGG
>NC_012469.1|WP_000863509.1|1073415_1073763_-|DUF1831-domain-containing-protein
MAFEKIIQLKNCRYDYTLSPSVKKFTLKDNTFFETKVGNYELTRLLEKVPNSGEGFQLKIIINKELTGAKINITDKFGLRLVDIFKSEDHHIHQEKFYFLMDSLVERGVFTKSER
>NC_012469.1|WP_010963271.1|1073192_1073444_-|DUF4649-family-protein
MVSLQNRKDRAKMFELTYKDCYHVERTLKYEDHEALMLTLSGCVTLPDTLYVTSLTFRGKKVYQGLVGDLYRFLSHADFLHQN
>NC_012469.1|WP_000653403.1|1072468_1073110_-|redox-sensing-transcriptional-repressor-Rex
MKDKQFAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIGIDSATVRRDFSYFGELGRRGFGYDVKKLMTFFADLLNDNSITNVMLVGIGNMGHALLHYRFHERNKMKIIMAFDLDDHPEVGTQTPDGIPIYGISQIKDKIKDADVKTAILTVPSVKSQEVANLLVDAGVKGILSFSPVHLHLPKDVVVQYVDLTSELQTLLYFMRKED
>NC_012469.1|WP_000981526.1|1081938_1082238_-|YbaB/EbfC-family-nucleoid-associated-protein
MMNMQNMMRQAQKLQKQMEQSQAELAAMQFVGKSAQDLVQATLTGDKKVVSIDFNPAVVDPEDLETLSDMTVQAINSALEQIDETTKKKLGAFAGKLPF
>NC_012469.1|WP_000509041.1|1082639_1083338_+|DUF1275-domain-containing-protein
MGGKMRLLPIRKISRQSKRLALFLTFCAGYVDAYTFIVRGNTLVAGQTGNVVFLSVELIKNNVSDVRDKVLTLLAFMMGVFLLTIYKEKLRIVKKPILSLIPLAILSIIIAFVPQTVDNIYLVPPLAFCMGLVTTAFGEVSGIAYNNAFMTGNIKRTMLAFGDYFRTKHTPFLREGFIFVSLLSSFVLGVVFSAYLTIFYHEKTILGVPIMMSVFYLSMLFASWQKKVKEKA
>NC_012469.1|WP_000109141.1|1083525_1083840_+|50S-ribosomal-protein-L21
MSTYAIIKTGGKQVKVEVGQAVYVEKLNVEAGQEVTFNEVVLVGGENTVVGTPLVAGATVVGTVEKQGKQKKVVTYKYKPKKGSHRKQGHRQPYTKVVINAINA
>NC_012469.1|WP_000613700.1|1083855_1084200_+|ribosomal-processing-cysteine-protease-Prp
MIQAVFERAEDGELRSAEITGHAESGEYGLDVVCASVSTLAINFINSIEKFAGYEPILELNEDEGGYLMVEIPKDLPSHQREMTQLFFESFFLGMANLSENYSEFVQTRVITEN
>NC_012469.1|WP_000916509.1|1084216_1084510_+|50S-ribosomal-protein-L27
MLKMTLNNLQLFAHKKGGGSTSNGRDSQAKRLGAKAADGQTVTGGSILYRQRGTHIYPGVNVGRGGDDTLFAKVEGVVRFERKGRDKKQVSVYPIAK
>NC_012469.1|WP_000587444.1|1085357_1086275_+|bifunctional-riboflavin-kinase/FAD-synthetase
MIITIPIKNQKDIGTPSDSVVVLGYFDGIHKGHQELFRVANKAARKDLLPIVVMTFNESPKIALEPYHPDLFLHILNPAERERKLKREGVEELYLLDFSSQFASLTAQEFFATYIKAMNAKIIVAGFDYTFGSDKKTAEDLKDYFDGEVIIVPPVEDEKGKISSTRIRQAILDGNVKEAGKLLGAPLPSRGMVVHGNARGRTIGYPTANLVLLDRTYMPADGVYVVDVEIQRQKYRAMASVGKNVTFDGEEARFEVNIFDFNQDIYGETVMVYWLDRIRDMTKFDSVDQLVDQLKADEEVTRNWS
>NC_012469.1|WP_000592056.1|1086367_1087216_-|YitT-family-protein
MIKKIYPIFTILLGAAIYAFGLTYFVVPHHLFEGGATGITLITFYLFKIPVSLMNLLINIPLFILAWKIFGAKSLYSSLLGTLALSAWLAFFEHIPLHIDLQGDLLITALIAGILLGIGLGIIFNAGGTTGGTDILARILNKYTHISIGKLLFILDFCILMLILLIFKDLRLVSYTLLFDFIVSRVIDLIGEGGYAGKGFMIITKRPDQLAKAINDDLGRGVTFISGQGYYSKENLKIIYCIVGRNEIVKTKEMIHRIDPQAFITITEAHEILGEGFTFEKE
>NC_012469.1|WP_000161392.1|1087357_1088197_+|DegV-family-protein
MTKIKIVTDSSVTIEPELVKQLDITIVPLSVMIDNVVYSDADLKEEGKFLQLMQESKNLPKTSQPPVGVFAEIFEDLCKDGGQILAIHMSHALSGTVEAARQGASLSTADVTVVDSSFTDQALKFQVVEAAKLAQEGKDMEAILCHVEEVKNHTELYIGVSTLENLVKGGRISRVTGLLSSLLNIRVVMQMKDHELQPMVKGRGTKTFKKWLDELITSLSERAVAEIGISYSGSDDWAKEMKESLQAYVEKPISVLETGSIIQTHTGENAWAILIRYHS
>NC_012469.1|WP_001284639.1|1088303_1088579_+|HU-family-DNA-binding-protein
MANKQDLIAKVAEATELTKKDSAAAVEAVFAAVADYLAAGEKVQLIGFGNFEVRERAERKGRNPQTGKEMTIAASKVPAFKAGKALKDAVK
>NC_012469.1|WP_000584888.1|1089005_1090907_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MIILQANKIERSFAGEVLFDNINLQVDERDRIALVGKNGAGKSTLLKILVGEEEPTSGEINKKKDISLSYLAQDSRFESENTIYDEMLHVFNNLRRTERQLRQMELEMGEKSGEDLDKLMSDYDRLSENFRQAGGFTYEADIRAILNGFKFDESMWQMKIAELSGGQNTRLALAKMLLEKPNLLVLDEPTNHLDIETIAWLENYLVNYSGALLIVSHDRYFLDKVATITLDLTKHSLDRYVGNYSRFVELKEQKLATEAKNYEKQQKEIAALEDFVNRNLVRASTTKRAQSRRKQLEKMERLDKPEAGKKAANMTFQSEKTSGNVVLTVENTAIGYDGEVLSQPINLDLRKMNAVAIVGPNGIGKSTFIKSIVDQIPFIKGEKRFGANVEVGYYDQTQSKLTPSNTVLDELWNDFKLTPEVEIRNRLGAFLFSGDDVKKSVGMLSGGEKARLLLAKLSMENNNFLILDEPTNHLDIDSKEVLENALIDFDGTLLFVSHDRYFINRVATHVLELSENGSTLYLGDYDYYVEKKATAEMSQTEEASTSNQAKEASPVNDYQAQKESQKEVRKLMRQIESLEAEIEELESQSQAISEQMLETNDADKLMELQAELDKISHRQEEAMLEWEELSDQV

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Crispr_ID: NC_012469_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012469_2

1410988-1411120

Orphan

Consensus_repeat	Method
ACTTCTGGTGTCGGTACATTTGGTG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_012469_2

>merge|NC_012469|2|1410988-1411120|CRISPRCasFinder
TGTTCTGGAACCGGTACTTCTGGTGTTGGAACAGCTGGAGTTGGTTGTACTGGCACTTCTGGTGTCGGTACATTTGGTGTTGGTTGCGCTGGCACAGGTTTAACCAGTACTTCTGGTGTCGGCACATTTGGTG

>NC_012469|2|2|1410988-1411120|CRISPRCasFinder
TGTTCTGGAACCGGTACTTCTGGTG	TTGGAACAGCTGGAGTTGGTTGTACTGGC
ACTTCTGGTGTCGGTACATTTGGTG	TTGGTTGCGCTGGCACAGGTTTAACCAGT
ACTTCTGGTGTCGGCACATTTGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012469.1\|WP_001151785.1\|1405859_1406150_-\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NC_012469.1\|WP_000822863.1\|1419209_1420805_-\|hypothetical-protein	unknown	unknown	unknown
NC_012469.1\|WP_000339034.1\|1403411_1404812_-\|bifunctional-Cof-type-HAD-IIB-family-hydrolase/peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223725
NC_012469.1\|WP_000697775.1\|1418172_1418901_-\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|234999
NC_012469.1\|WP_000032458.1\|1422146_1424843_-\|cation-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319781
NC_012469.1\|WP_001865572.1\|1428341_1429541_-\|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|237339
NC_012469.1\|WP_000412220.1\|1420816_1421227_-\|peptide-deformylase	unknown	unknown	gnl\|CDD\|181704
NC_012469.1\|WP_000167151.1\|1406302_1407646_-\|asparagine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235176
NC_012469.1\|WP_001279133.1\|1426473_1428345_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_012469.1\|WP_000813916.1\|1425146_1426331_+\|CDF-family-manganese-efflux-transporter-MntE	unknown	unknown	gnl\|CDD\|223131
NC_012469.1\|WP_000039614.1\|1410015_1410564_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223508
NC_012469.1\|WP_000777792.1\|1408022_1409210_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NC_012469.1\|WP_000689600.1\|1403050_1403410_-\|S1-RNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|180908
NC_012469.1\|WP_000565216.1\|1407805_1408030_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319923
NC_012469.1\|WP_001106134.1\|1416613_1418122_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|285470
NC_012469.1\|WP_000153791.1\|1409206_1409638_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227656
NC_012469.1\|WP_000068664.1\|1405106_1405346_-\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NC_012469.1\|WP_001277403.1\|1421342_1422134_-\|glutathione-dependent-disulfide-bond-oxidoreductase	unknown	unknown	gnl\|CDD\|183298
NC_012469.1\|WP_000609607.1\|1405377_1405848_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|180915
NC_012469.1\|WP_000389568.1\|1418979_1419159_-\|YczI-family-protein	unknown	unknown	gnl\|CDD\|315732

Protein	Function_ID	Function_description	E-value
NC_012469.1\|WP_001151785.1\|1405859_1406150_-\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	1.40041e-37
NC_012469.1\|WP_000339034.1\|1403411_1404812_-\|bifunctional-Cof-type-HAD-IIB-family-hydrolase/peptidylprolyl-isomerase	gnl\|CDD\|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	5.47265e-62
NC_012469.1\|WP_000697775.1\|1418172_1418901_-\|peroxide-stress-protein-YaaA	gnl\|CDD\|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	5.15942e-96
NC_012469.1\|WP_000032458.1\|1422146_1424843_-\|cation-translocating-P-type-ATPase	gnl\|CDD\|319781	cd02089, P-type_ATPase_Ca_prok, prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1. Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_012469.1\|WP_001865572.1\|1428341_1429541_-\|CCA-tRNA-nucleotidyltransferase	gnl\|CDD\|237339	PRK13299, PRK13299, tRNA CCA-pyrophosphorylase; Provisional.	0
NC_012469.1\|WP_000412220.1\|1420816_1421227_-\|peptide-deformylase	gnl\|CDD\|181704	PRK09218, PRK09218, peptide deformylase; Validated.	5.2801e-91
NC_012469.1\|WP_000167151.1\|1406302_1407646_-\|asparagine--tRNA-ligase	gnl\|CDD\|235176	PRK03932, asnC, asparaginyl-tRNA synthetase; Validated.	0
NC_012469.1\|WP_001279133.1\|1426473_1428345_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0
NC_012469.1\|WP_000813916.1\|1425146_1426331_+\|CDF-family-manganese-efflux-transporter-MntE	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	3.68565e-101
NC_012469.1\|WP_000039614.1\|1410015_1410564_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223508	COG0431, COG0431, Predicted flavoprotein [General function prediction only].	1.09403e-32
NC_012469.1\|WP_000777792.1\|1408022_1409210_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0
NC_012469.1\|WP_000689600.1\|1403050_1403410_-\|S1-RNA-binding-domain-containing-protein	gnl\|CDD\|180908	PRK07252, PRK07252, S1 RNA-binding domain-containing protein.	1.98721e-79
NC_012469.1\|WP_000565216.1\|1407805_1408030_-\|hypothetical-protein	gnl\|CDD\|319923	cd07262, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.22811e-09
NC_012469.1\|WP_001106134.1\|1416613_1418122_+\|transcriptional-regulator	gnl\|CDD\|285470	pfam08270, PRD_Mga, M protein trans-acting positive regulator (MGA) PRD domain. Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This corresponds to the PRD like region.	1.11813e-76
NC_012469.1\|WP_000153791.1\|1409206_1409638_-\|hypothetical-protein	gnl\|CDD\|227656	COG5353, COG5353, Uncharacterized protein conserved in bacteria [Function unknown].	1.44816e-57
NC_012469.1\|WP_000068664.1\|1405106_1405346_-\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	3.32721e-37
NC_012469.1\|WP_001277403.1\|1421342_1422134_-\|glutathione-dependent-disulfide-bond-oxidoreductase	gnl\|CDD\|183298	PRK11752, PRK11752, putative S-transferase; Provisional.	0
NC_012469.1\|WP_000609607.1\|1405377_1405848_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|180915	PRK07275, PRK07275, single-stranded DNA-binding protein; Provisional.	1.66017e-101
NC_012469.1\|WP_000389568.1\|1418979_1419159_-\|YczI-family-protein	gnl\|CDD\|315732	pfam13129, DUF3953, Protein of unknown function (DUF3953). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 47 and 76 amino acids in length.	7.99728e-05

>NC_012469.1|WP_000039614.1|1410015_1410564_+|NAD(P)H-dependent-oxidoreductase
MSKKVLFIVGSLRQGSFNHQMALEAEKALAGKAEVSYLDYSALPLFSQDLEVPTHPAVAAAREAVLVADAIWIFSPVYNFSIPGTVKNLLDWLSRALDLSDTRGASALQDKFVTVSSVANAGHDQLFAIYKDLLPFIRTQGVGDFTAARVNDSAWADGKLVLEETVLNSLEKQAQDLVEAIQ
>NC_012469.1|WP_000153791.1|1409206_1409638_-|hypothetical-protein
MTILFVVISASFLYMVSLSMKPYQTAKSEGEKLAQQYAGLEQADQVDLYNGLESYYSVLGRNKQQEALAVLIGKDDHKIYVYQLNQGVSQEKAETVSKEKGAGEIDKIIFGRYQDKPIWEVKSGSDFYLVDFETGALVNKEGL
>NC_012469.1|WP_000777792.1|1408022_1409210_-|pyridoxal-phosphate-dependent-aminotransferase
MKLSNRVLEMEESVTLAAGARAKALKAEGRDILSLTLGEPDFTTPKNIQDAAIASIRDGRASFYTVTSGLPELKAVVNSYFERFYGYSVASNQVTVAAGAKYSLYTFFMAVVNPGDEVIIPTPYWVSYGDQVKMAEGVPVFVSAKEDNHFKVTVEQLEVARTDKTKVLVLNSPSNPTGMIYTREELLAIGNWAVENDILILADDIYGRLVYNGHEFTPISSLSEAIRKQTVVINGVSKTYAMTGWRIGYAVGEADIIAAMSKIAGQTTSNPSAVAQYAAVEALSGEQDTVESMRQAFEERLNTIYPLLAEVPGFEVVKPQGAFYLFPNVKKAMEMKGYTDVTDFTTAILEESEVALVTGAGFGAPENVRLSYATDLDTLKEAVERLKAFMGSEND
>NC_012469.1|WP_000565216.1|1407805_1408030_-|hypothetical-protein
MIDHFEIKVKDLQISEGFYRSFLAPLDYKLAFKTSSLISFLSPNSPHPGGDFWLTQGTQDPVHFAFLAENKEEV
>NC_012469.1|WP_000167151.1|1406302_1407646_-|asparagine--tRNA-ligase
MTKRVTIIDVKDYVGQEVTIGAWVANKSGKGKIAFLQLRDGTAFFQGVAFKPNFVEKFGEEVGLEKFDVIKRLSQETSVYVTGIVKEDERSKFGYELDITDIEVIGESQDYPITPKEHGTDFLMDNRHLWLRSRKQVAVLQIRNAIIYATYEFFDKNGFMKFDSPILSGNAAEDSTELFETDYFGTPAYLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSYLTHDESLDLQEAYVKALLQGVLDRAPQALETLERDTELLKRYIAEPFKRITYDQAIDLLQEHENDEDADYEHLEHGDDFGSPHETWISNHFGVPTFVMNYPAAIKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREEDYDALVAKMDELGMDRTEYEFYLDLRKYGTVPHGGFGIGIERMVTFAAGTKHIREAIPFPRMLHRIKP
>NC_012469.1|WP_001151785.1|1405859_1406150_-|30S-ribosomal-protein-S6
MAKYEILYIIRPNIEEEAKNALVARFDSILTDNGATVVESKTWEKRRLAYEIQDFREGLYHIVNVEANDDAALKEFDRLSKINADILRHMIVKIDA
>NC_012469.1|WP_000609607.1|1405377_1405848_-|single-stranded-DNA-binding-protein
MINNVVLVGRMTRDAELRYTPSNVAVATFTLAVNRTFKSQNGEREADFINVVMWRQQAENLANWAKKGSLIGVTGRIQTRSYDNQQGQRVYVTEVVAENFQMLESRSVREGHTGGAYSAPTANYSAPTNSVPDFSRNENPFGATNPLDISDDDLPF
>NC_012469.1|WP_000068664.1|1405106_1405346_-|30S-ribosomal-protein-S18
MAQQRRGGFKRRKKVDYIAANKIEYVDYKDTELLSRFVSERGKILPRRVTGTSAKNQRKVTTAIKRARVMALMPFVNED
>NC_012469.1|WP_000339034.1|1403411_1404812_-|bifunctional-Cof-type-HAD-IIB-family-hydrolase/peptidylprolyl-isomerase
MDAKLRYKAKKIKIVFFDIDDTLRNSKTGFIPTTIPTVFKQLREKGILTGIASGRGIFGVVPEIRDLKPDFFVTLNGAYIEDKKGQVIYQHQIGKSDVEEYISWAKQEGIEYGLVGSHDAKLSTRTDMMSEAINPIYPDLDVDPDFHEKEDIYQMWTFEDKGDDLHLPDSLSDKLRMVRWHQHSSDIVPISGSKATGVEKVVEHLGLKPEKVMVFGDGLNDLELFDYAGISVAMGISHDKIKEKADYITKTLEEDGIFDALEVFGMVEKELHFPQVDIETVEGPLATIKTNHGDLRIKLFPEHAPKTVANFVSLSKDGYYDGVIFHRIIKDFMIQGGDPTGTGMGGESIYGESFEDEFSEELYNIRGALSMANAGPNTNGSQFFIVQNQHLPYSKKEITRGGWPEPIAEIYANQGGTPHLDRRHTVFGQLADEASYAVLDAIAAVETGAMDKPVEDVVIETIEIED
>NC_012469.1|WP_000689600.1|1403050_1403410_-|S1-RNA-binding-domain-containing-protein
MKIGDKLKGRITGIQPYGAFVELETGDTGLIHISEIRTGFIENIHETLKVDEEVQVQVVDLDEFTGKASLSIRTLEEEKYQFPRRRRFSSDRFNYGFAPFRRMLPIWTGEALHYLKKKK
>NC_012469.1|WP_001106134.1|1416613_1418122_+|transcriptional-regulator
MNYGENTRMRNLLSTKVQRQLRLMENLIQNRNWMKLHELAEKLGCTERILKSDLNELRIAFPSINIQSSVNGIMIDLEVNTSVEDIYQYFLANSQSFQLLEYMFFNEGLPIYRTIENLYFSSANLYRLGRNITKVLSSQFQIELSFTPSEIRGNEIDIRYFFAQYFSERYYFLDWPFPDLPEEDLTEFADFFYKITNYPMRFSIYRMYKLMIAISIHRVKNGHFIDLPNHFYKEYYPLLKSIPNFQETLAYFSKHFGLEMTPDTIAQIFISFLQNDIFLDPQEFFNSLEDNSQARYSYQLLSQILERLSKQYKITFTNHDELIWHLHNTAFFERQEIFSTPILFEQKALTIKKFEVYFPDFMGSARQELAQYRQAIGQHDHPEQLEHLMYTILTHAENLSTQLLENRPPIKVLIISNFDHAISLTFVDMLSYYCNNRFTFDIWDELKTSPEILNQTDYDIIVSNFYIPGITKKFICRNHLSIINLVNHLNTLSNEIHLSNTL
>NC_012469.1|WP_000697775.1|1418172_1418901_-|peroxide-stress-protein-YaaA
MKILIPTAKEMNTDLPSIEAIPLKPESQTVLDALALYSASQLESFYKVSAEKAAEEFQNIQALKRQTAQHYPALKLFDGLMYRNIKRDKLTEAEQDYLENHVFITSALYGVVPALSPMAPHRLDFLMKLKVAGKTLKSHWKAVYDEALKKEEVIFSLLSSEFETVFSKEIRAKMVTFKFMEDRGGQLKIHSTISKKARGAFLTALIENQVQTVGEARRLNFAGFVYREDLSQPQGLVFVKEV
>NC_012469.1|WP_000389568.1|1418979_1419159_-|YczI-family-protein
MEDKEMGFYLMVASMLLGLLALKIGFSQFKEKKDKFLSILTSLAGTALVLVAVWLGWPK
>NC_012469.1|WP_000822863.1|1419209_1420805_-|hypothetical-protein
MKRIVFELIFIATTWYIFLPPLNLTSWEFLFFLCGHLLVVAILFGFGKGINLVKTVHVRHGKAEAALNLEGFKINRLGKILLASIGGILLLAALVSLVTSSMFQAKNYANVVTVTEKDFTEFPKSDTSKVPILDRSTAEKIGDRYLGSLTDKVSQYVAADTYTQLTIDGKPYRVTPLEYADPIKWFNNQAKGIGEYIKVDMVTGNADLVDLKTPIKYSDSEYFNRDVKRHLRLKYPTKIFKTPSFEVDDEGNPFYVATVYQKQFGLAVPRPASVIILDATNGETKEYSLSDVPEWVDRIYPAEETIEQINYNGKYKDGFLNAMISKKNVTQTTNGYNYLSIGNDIYLYTGVTSANADESNLGFILENMRTGEITKYSLASATEESARESAEGAVQEKSYKATFPILINLNDKPLYIMGLKDNAGLVKEYALVDAVEYQNVIVATTVEEMLSKYANKNDLEIDNATTESIKGVVADLKSAVIKGDTVYFFKVDGKIYKVKASVSDDLPYLENGKTFEGQVGKDNYLKTFKLR
>NC_012469.1|WP_000412220.1|1420816_1421227_-|peptide-deformylase
MEKKIVKDILFLSQVSQPASQEDLYLARDLQDTLLANRDTCVGLAANMIGVQKRVIIFNLGLVPVVMFNPVLLSFEGSYEAEEGCLSLVGVRSTKRYETIRLAYRDSKWQEQTITLTGFPAQICQHELDHLEGRII
>NC_012469.1|WP_001277403.1|1421342_1422134_-|glutathione-dependent-disulfide-bond-oxidoreductase
MSAYQLPTVWQDEASNQGAFTGLNRPTAGARFEQNLPKGEQAFQLYSLGTPNGVKVTILLEELLEAGFKEAAYDLYKIAIMDGDQFGSDFVKLNPNSKIPALLDQSGTENVRVFESAHILLYLAEKFGAFLPSNPVEKVEVLNWLFWQAGAAPFLGGGFGHFFNYAPEKLEYPINRFTMEVKRQLDLLDKELAQKPYIAGNDYTIADIAIWSWYGQLVQGNLYQGSAKFLDASSYQNLVKWAEKIANRPAVKRGLEVTYTEIK
>NC_012469.1|WP_000032458.1|1422146_1424843_-|cation-translocating-P-type-ATPase
MSKEQKRQAFYTQSPEEVLQAVDATEQGLSSSEAEKRLAEFGHNELEEGEKRSILVKFIEQFKDLMIIILVAAAILSVVTSGGEDIADAIIILAVVIINAAFGVYQEGKAEEAIEALKSMSSPVARVLRDGHMAEIDSKELVPGDIVALEAGDVVPADLRLIEANSLKIEEAALTGESVPVEKDLSVELATDAGIGDRVNMAFQNSNVTYGRGMGVVVNTGMYTEVGHIAGMLQDADETDTPLKQNLNNLSKVLTYAILVIALVTFVVGVFIQGKNPLGELLTSVALAVAAIPEGLPAIVTIVLSLGTQVLAKRHSIVRKLPAVETLGSTEIIASDKTGTLTMNKMTVEKVFYDAVLHDSADDIELGLEMPLLRSVVLANDTKIDVEGNLIGDPTETAFIQYALDKGYDVKGFLEKYPRVAELPFDSDRKLMSTVHPLPDGRFLVAVKGAPDQLLKRCLLRDKAGDIAPIDEKVTNLIHTNNSEMAHQALRVLAGAYKIIDSIPENLTSEELENDLIFTGLIGMIDPERPEAAEAVRVAKEAGIRPIMITGDHQDTAEAIAKRLGIIDANDTEGHVLTGAELNELSDEEFEKVVGQYSVYARVSPEHKVRIVKAWQKQGKVVAMTGDGVNDAPALKTADIGIGMGITGTEVSKGASDMILADDNFATIIVAVEEGRKVFSNIQKTIQYLLSANTAEVLTIFLSTLFGWDVLQPVHLLWINLVTDTFPAIALGVEPAEPGVMNHKPRGRKASFFSGGVLSSIIYQGVLQAALVMSVYGLAIAYPVHVGDNHAIHADALTMAFATLGLIQLFHAYNVKSVYQSILTVGPFKSKTFNWSILVSFILLMATIVVEPLEGIFHVTKLDLSQWGIVMAGSFSMIIIVEIVKFIQRKLGFDKNAI
>NC_012469.1|WP_000813916.1|1425146_1426331_+|CDF-family-manganese-efflux-transporter-MntE
MKQSISNLKLAERGAIISISTYLILSAAKLAAGHLLHSSSLVADGFNNVSDIIGNVALLIGIRMARQPADRDHRFGHWKIEDLASLITSIIMFYVGFDVLRDTIQKILSREETVIDPLGATLGIISAAIMFVVYLYNTRLSKKSNSKALKAAAKDNLSDAVTSLGTAIAILASSFNYPIVDKLVAIIITFFILKTAYDIFIESSFSLSDGFDDRLLEDYQKAIMEIPKISKVKSQRGRTYGSNIYLDITLEMNPDLSVFESHEIADQVESMLEERFGVFDTDVHIEPAPIPEDEILDNVYKKLLMREQLIDQGNQLEELLTDDFVYIRQDGEQMDKEAYKTKKELNSAIKDIQITSISQKTKLICYELDGIIHTSIWRRHETWQNIFHQETKKE
>NC_012469.1|WP_001279133.1|1426473_1428345_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSDFIVEKLSKSVGDKTVFRDISFIIHDLDRIGLIGVNGTGKTTLLDVLSGVSGFDGDVSPFSAKNDYQIGYLTQDPDFDDRKTVLDTVLSSELKEIQLIREYELIMLDYSEDKQARLERVMAEMDSLQAWEIESQVKTVLSKLGIQDLSTPVGELSGGLRRRVQLAQVLLGNHDLLLLDEPTNHLDIAIIEWLTLFLKNSKKTVLFITHDRYFLDALSTRIFELDRAGLTEYQGNYQDYVRLKAEQDERDAALLHKKEQLYKQELAWMRRQPQARATKQQARINRFHDLKKEVSGSSAETDLTMNFETSRIGKKVIEFQAVSFAYENKPILQDFNLLVQAKDRIGIVGDNGVGKSTLLNLIAGSLEPTKGQVVIGETVRIAYFSQQIEGLDESKRVINYLQEVAEEVKTSGGSTTSIAELLEQFLFPRSTHGTLIEKLSGGEKKRLYLLKLLLEKPNVLLLDEPTNDLDIATLTVLENFLQGFAGPVLTVSHDRYFLDKVATKILAFEDGKIRPFFGHYTDYLDEKAFETDMANQVQKVEKEKVVKVREDKKRMTYQEKQEWASIEGDIETLEKRIAAIEEEMQANGSDFGKLATLQKELDEKNEALLEKYERYEYLSEFDS
>NC_012469.1|WP_001865572.1|1428341_1429541_-|CCA-tRNA-nucleotidyltransferase
MRLTQMPSEFQKALPVLEKIKEAGFEAYFVGGSVRDALLHSPIHDVDIATSSYPEETKQIFPRTADIGIEHGTVLVLDGDEEYEVTTFRTEDVYVDYRRPSAVSFVRSLEEDLKRRDFTVNAFALDETGEIVDLFHGLEDLEKQVLRAVGVASERFNEDALRIMRGFRFQASLGFALEPETFKAMKTLTPLLEKISVERTFVEFDKLLLAPFWRRGLASMIESQAYDYLPDMASSQDKLNRLFDLETDFTFESSEQAWAALLWALEIENAQSLLKSWKTSRQFAKQVQDLLIILALRENGELSKRDCYRFDIDLLLQAENLRQAQGKEVNPQAITEKYQSLTIHDKKEIQINGGILIKEYGYQPGPDLGEILTEIEFAIVDGELENNREAIHAYLREKK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_012469_1	1.1\|1081809\|38\|NC_012469\|CRISPRCasFinder	1081809-1081846	38	KY065475	Streptococcus phage IPP35, complete genome	23044-23081	4	0.895
NC_012469_1	1.1\|1081809\|38\|NC_012469\|CRISPRCasFinder	1081809-1081846	38	MK448453	Streptococcus satellite phage Javan360, complete genome	13985-14022	5	0.868

1. spacer 1.1|1081809|38|NC_012469|CRISPRCasFinder matches to KY065475 (Streptococcus phage IPP35, complete genome) position: , mismatch: 4, identity: 0.895

ccctttttttctacaataaaataggctccataatatct	CRISPR spacer
gactttttttctacacaaaaataggctccataatatct	Protospacer
  *************  *********************

2. spacer 1.1|1081809|38|NC_012469|CRISPRCasFinder matches to MK448453 (Streptococcus satellite phage Javan360, complete genome) position: , mismatch: 5, identity: 0.868

ccctttttttctacaataaaataggctccataatatct	CRISPR spacer
gactttttttctacaacaaaataggctccataatattc	Protospacer
  **************.*******************..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

13047 : 23357

Streptococcus_phage(62.5%)

integrase,transposase

attL 13278:13292|attR 29829:29843

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000424684.1\|13047_13653_-	Rha family transcriptional regulator	A0A192Y918	Salmonella_phage	6.8e-18	34.1
13278:13292	attL	NA	NA	NA	NA
WP_014678319.1\|13674_14052_-	hypothetical protein	NA	NA	NA	NA
WP_012677155.1\|14244_15591_+\|transposase	IS1380-like element ISSpn5 family transposase	A0A1X9I6F6	Streptococcus_phage	9.9e-78	39.8
WP_001241280.1\|15834_16026_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_001814778.1\|16229_16946_+	helix-turn-helix domain-containing protein	A0A1S5SFG5	Streptococcus_phage	2.6e-77	63.0
WP_000666926.1\|16964_17633_+	zinc ribbon domain-containing protein	A0A141DZS3	Streptococcus_phage	8.4e-78	74.1
WP_000222518.1\|17771_18440_+	Fic family protein	D7RWK9	Brochothrix_phage	9.2e-08	24.6
WP_000255647.1\|18903_19362_-	hypothetical protein	A0A1X9I5V5	Streptococcus_phage	5.6e-25	46.0
WP_000417039.1\|20784_21090_+	hypothetical protein	NA	NA	NA	NA
WP_000422980.1\|21194_21755_+	multidrug DMT transporter	A0A1W6JPJ7	Morganella_phage	4.6e-21	56.1
WP_000704676.1\|22190_23357_+\|integrase	site-specific integrase	A0A1X9I5Y5	Streptococcus_phage	2.0e-103	51.5
29829:29843	attR	NA	NA	NA	NA

DBSCAN-SWA_2

60384 : 71840

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000668293.1\|60384_62538_+	peptide cleavage/export ABC transporter	W8CYL7	Bacillus_phage	1.0e-44	28.0
WP_000801629.1\|62550_63900_+	HlyD family secretion protein	NA	NA	NA	NA
WP_078102921.1\|64027_64777_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D8KNF0	Synechococcus_phage	1.4e-41	39.2
WP_000429436.1\|64787_64922_+	hypothetical protein	NA	NA	NA	NA
WP_000361166.1\|64978_68704_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	6.2e-37	25.5
WP_000220633.1\|68796_70239_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	5.7e-55	35.1
WP_000182580.1\|70275_71298_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SE90	Cyanophage	7.3e-65	44.2
WP_000717501.1\|71294_71840_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	9.7e-24	35.0

DBSCAN-SWA_3

113247 : 154683

Streptococcus_phage(50.0%)

tRNA,transposase,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012677166.1\|113247_114594_+\|transposase	IS1380-like element ISSpn5 family transposase	A0A1X9I6F6	Streptococcus_phage	4.5e-78	40.0
WP_001257240.1\|115665_115863_+	hypothetical protein	NA	NA	NA	NA
WP_000808434.1\|116099_117164_-	membrane protein	NA	NA	NA	NA
WP_001229057.1\|117226_118138_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_000198675.1\|118130_118724_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000273854.1\|118710_119037_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_000744897.1\|119175_120342_-	CynX/NimT family MFS transporter	NA	NA	NA	NA
WP_000096202.1\|120399_121557_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_001035700.1\|121598_123449_+	polysaccharide biosynthesis protein	A0A2P1ELS8	Moumouvirus	7.6e-28	30.5
WP_000200898.1\|123798_124431_-	HAD family hydrolase	NA	NA	NA	NA
WP_000500038.1\|124452_125325_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha	NA	NA	NA	NA
WP_000838912.1\|125333_126005_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit beta	NA	NA	NA	NA
WP_000836450.1\|126246_126834_+	LysM peptidoglycan-binding domain-containing protein	A0A288TY55	Enterococcus_phage	1.6e-27	56.7
WP_001189285.1\|126885_127206_-	hypothetical protein	NA	NA	NA	NA
WP_000227119.1\|127657_127906_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000723961.1\|127960_130069_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000571330.1\|130065_130707_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.3e-23	34.8
WP_001038474.1\|130913_131720_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_099516442.1\|131685_132156_+	argininosuccinate synthase	NA	NA	NA	NA
WP_001189278.1\|132445_132766_-	hypothetical protein	NA	NA	NA	NA
WP_000424418.1\|133524_133893_+\|bacteriocin	SP_0115 family bacteriocin-like peptide	NA	NA	NA	NA
WP_014632394.1\|133894_134101_+	hypothetical protein	NA	NA	NA	NA
WP_001268157.1\|134292_135156_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000915345.1\|135621_135960_+	peptidase C39	NA	NA	NA	NA
WP_000074494.1\|136056_136434_+	hypothetical protein	NA	NA	NA	NA
WP_000973716.1\|136587_136800_+	hypothetical protein	NA	NA	NA	NA
WP_000424467.1\|137215_137578_+	hypothetical protein	NA	NA	NA	NA
WP_000356083.1\|137558_137804_+	hypothetical protein	NA	NA	NA	NA
WP_001814711.1\|137960_139019_+	hypothetical protein	NA	NA	NA	NA
WP_000792250.1\|139334_140312_+	hypothetical protein	NA	NA	NA	NA
WP_000424474.1\|140688_141063_+\|bacteriocin	SPH_0224 family bacteriocin-like peptide	NA	NA	NA	NA
WP_000511668.1\|141069_141252_+	hypothetical protein	NA	NA	NA	NA
WP_000619753.1\|141270_142173_+	hypothetical protein	NA	NA	NA	NA
WP_013193366.1\|142195_142582_+	hypothetical protein	NA	NA	NA	NA
WP_000539711.1\|142548_143307_+	hypothetical protein	NA	NA	NA	NA
WP_000680086.1\|143785_143983_+	hypothetical protein	NA	NA	NA	NA
WP_073077614.1\|144381_144681_+	hypothetical protein	M1Q0Z8	Streptococcus_phage	1.2e-15	54.1
WP_000058768.1\|144699_144945_+	hypothetical protein	M1Q0Z8	Streptococcus_phage	1.3e-15	53.4
WP_001035384.1\|145230_147405_+	pneumococcal surface protein A	NA	NA	NA	NA
WP_001282969.1\|147805_148927_+\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_073077617.1\|149040_149523_+	NUDIX hydrolase	NA	NA	NA	NA
WP_000220964.1\|149532_151446_+\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG	NA	NA	NA	NA
WP_001809448.1\|151577_151727_-	hypothetical protein	NA	NA	NA	NA
WP_000331983.1\|151798_153478_-	ribonuclease J	NA	NA	NA	NA
WP_000639589.1\|153479_153713_-	DNA-dependent RNA polymerase auxiliary subunit epsilon family protein	NA	NA	NA	NA
WP_000282479.1\|153992_154208_+	hypothetical protein	NA	NA	NA	NA
WP_013315026.1\|154339_154537_-	hypothetical protein	NA	NA	NA	NA
WP_000974047.1\|154530_154683_-\|bacteriocin	fratricide two-peptide bacteriocin subunit CibB	NA	NA	NA	NA

DBSCAN-SWA_4

198095 : 208847

Streptococcus_phage(77.78%)

integrase

attL 198074:198090|attR 210739:210755

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
198074:198090	attL	NA	NA	NA	NA
WP_000704664.1\|198095_199262_-\|integrase	site-specific integrase	A0A1X9I5Y5	Streptococcus_phage	3.7e-153	70.1
WP_001233766.1\|199346_200861_-	ATPase AAA	NA	NA	NA	NA
WP_001107589.1\|201021_201735_-	helix-turn-helix domain-containing protein	Q708R9	Streptococcus_phage	2.0e-16	51.9
WP_000090006.1\|201887_202118_+	helix-turn-helix transcriptional regulator	X2KUC2	Streptococcus_phage	3.7e-09	47.0
WP_000424665.1\|202133_202760_+	Rha family transcriptional regulator	R9QNB1	Lactococcus_phage	2.1e-30	40.8
WP_000141100.1\|203131_203584_+	hypothetical protein	NA	NA	NA	NA
WP_000174331.1\|203580_203781_+	hypothetical protein	NA	NA	NA	NA
WP_001003774.1\|203782_203998_+	hypothetical protein	NA	NA	NA	NA
WP_000058832.1\|203994_204336_+	hypothetical protein	NA	NA	NA	NA
WP_000492137.1\|204328_204610_+	hypothetical protein	A0A1X9I5U9	Streptococcus_phage	7.9e-30	67.8
WP_000158192.1\|204744_205611_+	hypothetical protein	A0A1X9I6L2	Streptococcus_phage	8.2e-126	75.0
WP_000434359.1\|205663_207133_+	DNA primase	Q9AZI5	Lactococcus_phage	2.3e-64	35.0
WP_000173130.1\|207736_208267_+	hypothetical protein	A0A1X9I5U4	Streptococcus_phage	2.8e-36	48.7
WP_000811078.1\|208337_208847_+	hypothetical protein	A0A1X9I5V2	Streptococcus_phage	5.8e-47	53.9
210739:210755	attR	NA	NA	NA	NA

DBSCAN-SWA_5

348795 : 402942

Streptococcus_phage(25.0%)

transposase,protease,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001063396.1\|348795_350901_+\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	1.0e-116	37.6
WP_000032550.1\|351195_351678_-	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_000743620.1\|351772_353257_-	DUF1846 domain-containing protein	NA	NA	NA	NA
WP_001156769.1\|353409_355017_+	alpha-glucosidase	NA	NA	NA	NA
WP_033604964.1\|355181_355349_+	S-ribosylhomocysteinase	NA	NA	NA	NA
WP_000091077.1\|356436_357882_+	LCP family protein	A0A1X9I5X1	Streptococcus_phage	3.6e-134	60.1
WP_000565348.1\|357883_358615_+	tyrosine-protein phosphatase CpsB	NA	NA	NA	NA
WP_000664166.1\|358623_359316_+	capsular polysaccharide biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	4.3e-61	55.9
WP_001142521.1\|359325_360009_+	polysaccharide biosynthesis tyrosine autokinase CpsD	A0A1X9I5D6	Streptococcus_phage	1.3e-70	60.9
WP_000343581.1\|360024_361392_+	sugar transferase	NA	NA	NA	NA
WP_001205625.1\|361395_362139_+	WecB/TagA/CpsF family glycosyltransferase	NA	NA	NA	NA
WP_001076786.1\|362135_362960_+\|holin	LPS cholinephosphotransferase	A0A1V0SD50	Indivirus	1.8e-05	38.7
WP_000458863.1\|362961_363840_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_000120848.1\|363840_365178_+	oligosaccharide repeat unit polymerase	NA	NA	NA	NA
WP_001092842.1\|365200_366622_+	hypothetical protein	NA	NA	NA	NA
WP_000723326.1\|366685_367774_+	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	A0A1V0SAG5	Catovirus	1.0e-27	30.3
WP_000676118.1\|367812_368682_+	glucose-1-phosphate thymidylyltransferase RfbA	K7QKA7	Escherichia_phage	9.2e-101	63.2
WP_000131463.1\|368682_369279_+	dTDP-4-dehydrorhamnose 3,5-epimerase	H9NC63	Sphingomonas_phage	3.0e-10	32.8
WP_000141500.1\|369288_370338_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	8.3e-72	44.2
WP_000600898.1\|370403_371255_+	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	4.3e-26	35.4
WP_000842571.1\|372723_374706_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001032472.1\|375006_380310_+	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_001041857.1\|380475_382635_-	PBP1A family penicillin-binding protein	NA	NA	NA	NA
WP_000248773.1\|382631_383228_-	Holliday junction resolvase RecU	A0A1L2JY30	Aeribacillus_phage	1.5e-17	33.9
WP_000179553.1\|383294_383822_+	DUF1273 domain-containing protein	NA	NA	NA	NA
WP_000200644.1\|383891_384233_+	cell division regulator GpsB	NA	NA	NA	NA
WP_000711398.1\|384718_385876_+	class I SAM-dependent RNA methyltransferase	NA	NA	NA	NA
WP_000039290.1\|385888_387283_+	mid-cell-anchored protein MapZ	NA	NA	NA	NA
WP_000158792.1\|387358_388783_+	NADP-dependent phosphogluconate dehydrogenase	M4QQM4	Ostreococcus_lucimarinus_virus	2.7e-41	29.6
WP_000518011.1\|388794_389484_+	response regulator transcription factor	NA	NA	NA	NA
WP_000698035.1\|389581_390544_+\|holin	choline-binding protein CbpC	NA	NA	NA	NA
WP_000771128.1\|390562_391561_+\|holin	choline-binding protein CbpJ	NA	NA	NA	NA
WP_000765677.1\|391678_392911_-	MFS transporter	NA	NA	NA	NA
WP_001822134.1\|392953_393541_-	lanthionine synthetase	NA	NA	NA	NA
WP_001816235.1\|393440_393779_-	lantibiotic-modifying protein	NA	NA	NA	NA
WP_000196972.1\|394441_394771_+\|transposase	transposase	NA	NA	NA	NA
WP_000163329.1\|394892_395771_+	mevalonate kinase	NA	NA	NA	NA
WP_000373456.1\|395752_396706_+	diphosphomevalonate decarboxylase	NA	NA	NA	NA
WP_000562377.1\|396692_397700_+	phosphomevalonate kinase	NA	NA	NA	NA
WP_000210628.1\|397683_398694_+	type 2 isopentenyl-diphosphate Delta-isomerase	NA	NA	NA	NA
WP_001224634.1\|398771_399470_+	cell wall-active antibiotics response protein	NA	NA	NA	NA
WP_000743662.1\|399466_400462_+	sensor histidine kinase	NA	NA	NA	NA
WP_000698433.1\|400475_401108_+	response regulator transcription factor	NA	NA	NA	NA
WP_075218746.1\|401275_401587_+	DNA alkylation repair protein	NA	NA	NA	NA
WP_000754506.1\|402027_402942_+\|protease	serine protease	NA	NA	NA	NA

DBSCAN-SWA_6

475180 : 536532

Streptococcus_phage(20.0%)

tRNA,transposase,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001810089.1\|475180_475351_-\|transposase	transposase	NA	NA	NA	NA
WP_000628994.1\|476004_477228_-	ROK family transcriptional regulator	NA	NA	NA	NA
WP_073078459.1\|477391_478717_+	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_023356947.1\|478664_480605_+	DUF4838 domain-containing protein	NA	NA	NA	NA
WP_000836781.1\|480772_481117_+	PTS lactose/cellobiose transporter subunit IIA	NA	NA	NA	NA
WP_000429402.1\|481126_482539_+	6-phospho-beta-galactosidase	NA	NA	NA	NA
WP_000359753.1\|482607_484287_+	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_001809506.1\|484412_485852_-	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000691685.1\|485855_487205_-	Trk system potassium transporter TrkA	NA	NA	NA	NA
WP_001063601.1\|487392_488241_+	S-adenosyl-l-methionine hydroxide adenosyltransferase family protein	NA	NA	NA	NA
WP_000403169.1\|488255_488804_+	ECF-type riboflavin transporter substrate-binding protein	NA	NA	NA	NA
WP_000693286.1\|488810_489068_+	hypothetical protein	NA	NA	NA	NA
WP_000656522.1\|489169_490852_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.4e-19	34.4
WP_001148103.1\|490836_491667_+	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_000181380.1\|491859_492363_+\|tRNA	tRNA (cytidine(34)-2'-O)-methyltransferase	NA	NA	NA	NA
WP_000185835.1\|492815_493379_+	ECF transporter S component	NA	NA	NA	NA
WP_001842683.1\|493368_494019_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_000867296.1\|494045_494435_+	hypothetical protein	NA	NA	NA	NA
WP_000333653.1\|494439_494889_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_001808720.1\|495001_495604_+	DNA-directed RNA polymerase subunit delta	NA	NA	NA	NA
WP_000105242.1\|495993_497601_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	8.9e-142	47.0
WP_000026631.1\|498159_499791_-	Na/Pi cotransporter family protein	NA	NA	NA	NA
WP_000795202.1\|500079_505020_+	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_001096743.1\|505109_506306_+	phosphoglycerate kinase	NA	NA	NA	NA
WP_000119900.1\|506441_506969_+	aromatic acid exporter family protein	NA	NA	NA	NA
WP_000659547.1\|507045_507402_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_001122904.1\|507438_508785_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_001808898.1\|508880_509000_-	hypothetical protein	NA	NA	NA	NA
WP_000410535.1\|508964_509114_+	hypothetical protein	NA	NA	NA	NA
WP_001220748.1\|509566_510847_+	restriction endonuclease subunit S	A0A1V0SLK8	Klosneuvirus	8.1e-13	25.6
WP_000187223.1\|510794_512360_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_000029054.1\|512359_513823_-	SAM-dependent DNA methyltransferase	NA	NA	NA	NA
WP_000229085.1\|513835_516169_-	DEAD/DEAH box helicase	A0A097BY72	Enterococcus_phage	2.0e-25	28.9
WP_013193390.1\|516541_516742_+	hypothetical protein	NA	NA	NA	NA
WP_001088687.1\|516776_517286_+	DUF2812 domain-containing protein	NA	NA	NA	NA
WP_000255769.1\|517449_518484_+	heat-inducible transcriptional repressor HrcA	NA	NA	NA	NA
WP_000046031.1\|518510_519035_+	nucleotide exchange factor GrpE	NA	NA	NA	NA
WP_000034662.1\|519514_521338_+	molecular chaperone DnaK	A0A0N9QXN8	Chrysochromulina_ericina_virus	1.3e-133	47.2
WP_000115730.1\|521350_521704_+	hypothetical protein	NA	NA	NA	NA
WP_001066299.1\|521908_523045_+	molecular chaperone DnaJ	E3T4P7	Cafeteria_roenbergensis_virus	1.2e-23	31.0
WP_001808905.1\|523366_523561_-	hypothetical protein	NA	NA	NA	NA
WP_000777760.1\|523722_524010_-	hypothetical protein	NA	NA	NA	NA
WP_001278301.1\|524019_524430_-	HIT family protein	B5LJ12	Mycobacterium_phage	3.4e-05	31.6
WP_000889923.1\|524497_525229_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	9.0e-25	28.6
WP_000653752.1\|525225_526275_+	ABC transporter permease	NA	NA	NA	NA
WP_000132575.1\|526442_526772_-	hypothetical protein	NA	NA	NA	NA
WP_001816270.1\|527067_528414_-\|transposase	IS1380-like element ISSpn5 family transposase	A0A1X9I6F6	Streptococcus_phage	3.4e-78	40.0
WP_000682122.1\|528755_529094_+	response regulator transcription factor	NA	NA	NA	NA
WP_001219126.1\|529098_529836_+	response regulator transcription factor	NA	NA	NA	NA
WP_000275284.1\|529848_531189_+	sensor histidine kinase	NA	NA	NA	NA
WP_001816270.1\|531428_532775_-\|transposase	IS1380-like element ISSpn5 family transposase	A0A1X9I6F6	Streptococcus_phage	3.4e-78	40.0
WP_000358814.1\|532941_533097_-	quorum-sensing system pheromone BlpC	NA	NA	NA	NA
WP_001069099.1\|533153_534515_-\|bacteriocin	bacteriocin secretion accessory protein	NA	NA	NA	NA
WP_001093269.1\|536058_536307_+\|bacteriocin	bacteriocin	NA	NA	NA	NA
WP_000483697.1\|536322_536532_+\|bacteriocin	bacteriocin	NA	NA	NA	NA

DBSCAN-SWA_7

768416 : 775422

Streptococcus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000405832.1\|768416_768911_+	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	1.9e-42	52.1
WP_001170347.1\|768910_769441_+	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.4e-46	54.3
WP_000889093.1\|769434_769791_+	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.2e-33	57.3
WP_001103449.1\|769948_770749_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_000590986.1\|770748_771492_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.6e-29	41.0
WP_001206969.1\|771557_771794_+	DUF4059 family protein	NA	NA	NA	NA
WP_000272311.1\|771859_772771_+	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.9e-89	51.5
WP_000855734.1\|772808_773537_-	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_001272941.1\|773581_774193_-	peptide deformylase	E3SLL2	Synechococcus_phage	4.9e-16	42.4
WP_000930003.1\|774705_775422_+	CapA family protein	A0A0N9SJ77	Staphylococcus_phage	2.1e-26	30.9

DBSCAN-SWA_8

1199789 : 1210185

Streptococcus_phage(70.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001166874.1\|1199789_1200668_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	1.7e-115	75.7
WP_000358228.1\|1200670_1200988_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	2.9e-28	60.0
WP_000806706.1\|1201027_1201918_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	1.4e-72	51.4
WP_000033363.1\|1201914_1202553_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.2e-75	67.6
WP_000689709.1\|1202772_1203570_-	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	2.7e-59	50.6
WP_000254686.1\|1203573_1204836_-	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	2.5e-139	64.5
WP_001844793.1\|1204845_1205976_-	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.1e-114	58.4
WP_000728257.1\|1206055_1207939_-	MBL fold metallo-hydrolase	Q332B9	Clostridium_botulinum_C_phage	9.5e-10	23.7
WP_000403195.1\|1207941_1208829_-	RluA family pseudouridine synthase	A0A2H4UV25	Bodo_saltans_virus	1.3e-09	28.0
WP_000745389.1\|1208818_1209280_-	signal peptidase II	NA	NA	NA	NA
WP_001025704.1\|1209276_1210185_-	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	3.1e-06	27.7

DBSCAN-SWA_9

1435014 : 1441773

Streptococcus_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000081004.1\|1435014_1435983_+	NAD(P)/FAD-dependent oxidoreductase	Q9JRK7	Streptococcus_phage	1.8e-65	99.2
WP_000011306.1\|1436016_1436928_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	1.5e-154	99.7
WP_001231086.1\|1436924_1437902_-	YvcK family protein	A1IMD5	Streptococcus_phage	1.2e-184	100.0
WP_000163033.1\|1437898_1438789_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	3.9e-06	29.8
WP_001140420.1\|1438840_1439221_-	RidA family protein	NA	NA	NA	NA
WP_000422605.1\|1439231_1439819_-	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_001839487.1\|1439827_1441060_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	4.9e-132	59.2
WP_000442260.1\|1441096_1441267_-	hypothetical protein	NA	NA	NA	NA
WP_000162453.1\|1441266_1441773_-	dihydrofolate reductase	G3MBI7	Bacillus_virus	8.7e-27	42.5

DBSCAN-SWA_10

1696681 : 1704054

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001814725.1\|1696681_1697401_+	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	4.7e-34	36.2
WP_001108392.1\|1697397_1697550_+	hypothetical protein	NA	NA	NA	NA
WP_079199405.1\|1697831_1698806_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	1.2e-56	40.5
WP_001193665.1\|1698795_1699752_+	iron chelate uptake ABC transporter family permease subunit	NA	NA	NA	NA
WP_000764303.1\|1699748_1700501_+	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	5.6e-14	28.1
WP_000858251.1\|1700596_1701562_+	siderophore ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000821615.1\|1701786_1702029_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.8e-18	59.4
WP_001222228.1\|1702028_1702751_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_000105310.1\|1702737_1703307_-	segregation/condensation protein B	A0A1B1IVT7	uncultured_Mediterranean_phage	5.0e-15	34.9
WP_000351913.1\|1703325_1704054_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	4.1e-09	22.3

DBSCAN-SWA_11

1785495 : 1812067

Streptococcus_phage(92.0%)

transposase,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000420682.1\|1785495_1785810_+	YdcP family protein	A0A1S5SF38	Streptococcus_phage	5.2e-54	100.0
WP_000985015.1\|1785825_1786212_+	YdcP family protein	A0A1S5SF96	Streptococcus_phage	3.0e-64	100.0
WP_000813488.1\|1786240_1787626_+	DNA translocase FtsK	A0A1S5SFB5	Streptococcus_phage	1.1e-265	100.0
WP_000879507.1\|1787628_1787781_+	hypothetical protein	NA	NA	NA	NA
WP_000398284.1\|1787803_1789009_+	XRE family transcriptional regulator	A0A1S5SEX3	Streptococcus_phage	2.8e-233	100.0
WP_001009056.1\|1789051_1789273_+	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.3e-31	100.0
WP_000342539.1\|1789389_1789887_+	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.7e-91	100.0
WP_000506270.1\|1789861_1790368_+	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	8.6e-91	100.0
WP_000331160.1\|1790351_1792799_+	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	100.0
WP_012677156.1\|1792801_1794979_+	membrane protein	A0A1S5SF30	Streptococcus_phage	0.0e+00	98.5
WP_000769868.1\|1794975_1795977_+	peptidase P60	A0A1S5SEZ8	Streptococcus_phage	5.0e-191	100.0
WP_001224318.1\|1795973_1796906_+	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	3.1e-171	99.4
WP_012386611.1\|1797180_1797267_+	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_000691729.1\|1797282_1799202_+	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	97.3
WP_001813542.1\|1799565_1799811_+	hypothetical protein	A0A1B0RXA7	Streptococcus_phage	2.6e-37	98.8
WP_000806926.1\|1799807_1800143_+	hypothetical protein	NA	NA	NA	NA
WP_000567222.1\|1800155_1800524_+	hypothetical protein	A0A1B0RXA8	Streptococcus_phage	1.1e-58	97.5
WP_001072467.1\|1800510_1800810_+	hypothetical protein	A0A1B0RX98	Streptococcus_phage	1.8e-48	96.0
WP_000420313.1\|1800927_1802391_-	ABC-F type ribosomal protection protein Msr(D)	A0A1B0RXA0	Streptococcus_phage	3.7e-251	97.3
WP_000417519.1\|1802510_1803728_-	macrolide efflux MFS transporter Mef(A)	A0A2K5B2B5	Erysipelothrix_phage	5.1e-198	90.6
WP_000873143.1\|1804113_1804284_-	hypothetical protein	A0A1X9I6E4	Streptococcus_phage	3.7e-22	98.2
WP_001860868.1\|1804805_1804997_+	conjugal transfer protein	D0R0F6	Streptococcus_phage	5.4e-14	69.4
WP_001227347.1\|1805056_1805410_-	helix-turn-helix transcriptional regulator	A0A1S5SFA6	Streptococcus_phage	1.3e-58	100.0
WP_013670292.1\|1805614_1805686_+	hypothetical protein	NA	NA	NA	NA
WP_000804885.1\|1805914_1806337_+	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	2.5e-72	100.0
WP_000857133.1\|1806333_1806564_+	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	2.7e-36	100.0
WP_001845478.1\|1806789_1807041_-	hypothetical protein	NA	NA	NA	NA
WP_000814511.1\|1807024_1807228_+	excisionase	A0A1S5SF07	Streptococcus_phage	4.0e-31	100.0
WP_001291561.1\|1807309_1808527_+\|transposase	transposase	A0A1S5SEW7	Streptococcus_phage	3.7e-233	100.0
WP_000732395.1\|1809417_1811433_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000571425.1\|1811434_1812067_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.8e-22	32.9

DBSCAN-SWA_12

2090529 : 2099283

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000510412.1\|2090529_2091369_-	energy-coupling factor transporter ATPase	W8CYL7	Bacillus_phage	1.1e-15	32.6
WP_000835715.1\|2091353_2092181_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	2.8e-22	32.9
WP_000712136.1\|2092177_2092723_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_001844398.1\|2092733_2093564_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_000170193.1\|2093596_2094880_-	insulinase family protein	A0A1E1EST3	Acanthamoeba_castellanii_mimivirus	7.1e-17	29.5
WP_000424257.1\|2094876_2096127_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	6.0e-93	42.1
WP_000455903.1\|2096285_2096654_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	7.0e-18	57.3
WP_000266662.1\|2096656_2097754_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_000073428.1\|2097804_2099283_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	2.2e-94	40.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_012469

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection