CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_010337	Heliobacterium modesticaldum Ice1, complete sequence	10 crisprs	cas4,cas2,cas1,cas6,cas5,cas7,cas8a4,cas3,DEDDh,RT,cas6e,cse2gr11,cas8e,csa3	0	8	10	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_010337_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010337_1

267863-267971

Unclear

Consensus_repeat	Method
TCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CRISPRCasFinder

1 spacers

cas4,cas2,cas1,cas6,cas5,cas7,cas8a4

The CRISPR arrays of NC_010337_1

>merge|NC_010337|1|267863-267971|CRISPRCasFinder
TCAATCCCCTACATAGCGGGTCATCCAGTGAAACCTCTAGTAAGTCGACCCTTCATCGAAAAACCTCTTCCCCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC

>NC_010337|1|1|267863-267971|CRISPRCasFinder
TCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CTCTAGTAAGTCGACCCTTCATCGAAAAACCTCTTCCCCTT
TCAATCCCCTACATAGCGGGTCATCCAGTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_010337.2\|WP_012281430.1\|279354_281193_-\|hypothetical-protein	cas8a4	cls000706_cas8a4_CAS-I-A	unknown
NC_010337.2\|WP_148207043.1\|263665_264712_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_010337.2\|WP_012281187.1\|266033_267656_+\|IS1182-like-element-ISHmo2-family-transposase	unknown	unknown	gnl\|CDD\|377531
NC_010337.2\|WP_041313043.1\|261058_261655_-\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012281414.1\|254486_257138_-\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NC_010337.2\|WP_012281423.1\|272564_273185_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NC_010337.2\|WP_012281420.1\|264600_264927_-\|transposase	unknown	unknown	gnl\|CDD\|366690
NC_010337.2\|WP_012281424.1\|273178_273466_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NC_010337.2\|WP_012281418.1\|261721_263071_-\|dNTP-triphosphohydrolase	unknown	unknown	gnl\|CDD\|273571
NC_010337.2\|WP_012281187.1\|268168_269791_+\|IS1182-like-element-ISHmo2-family-transposase	unknown	unknown	gnl\|CDD\|377531
NC_010337.2\|WP_012281426.1\|274994_276356_+\|transposase	unknown	unknown	unknown
NC_010337.2\|WP_012281413.1\|254045_254324_-\|IreB-family-regulatory-phosphoprotein	unknown	unknown	gnl\|CDD\|180108
NC_010337.2\|WP_012281416.1\|257537_258359_-\|sirohydrochlorin-cobaltochelatase	unknown	unknown	gnl\|CDD\|368778
NC_010337.2\|WP_049754001.1\|273468_274521_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187766
NC_010337.2\|WP_187147793.1\|276683_277505_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	cas6	mkCas0066_cas6_CAS-I:CAS-III	gnl\|CDD\|337605
NC_010337.2\|WP_012281187.1\|258531_260154_+\|IS1182-like-element-ISHmo2-family-transposase	unknown	unknown	gnl\|CDD\|377531
NC_010337.2\|WP_148207154.1\|265036_265741_+\|transposase	unknown	unknown	unknown
NC_010337.2\|WP_012281429.1\|278375_279320_-\|DevR-family-CRISPR-associated-autoregulator	cas7	pfam01905_cas7_CAS-I	gnl\|CDD\|376656
NC_010337.2\|WP_012281422.1\|271429_272362_-\|type-I-A-CRISPR-associated-protein-Cas4/Csa1	cas4	pfam06023_cas4_CAS-I	gnl\|CDD\|283640
NC_010337.2\|WP_012281428.1\|277653_278361_-\|hypothetical-protein	cas5	cls000048_cas5_CAS-I-A	unknown

Protein	Function_ID	Function_description	E-value
NC_010337.2\|WP_148207043.1\|263665_264712_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	3.47253e-28
NC_010337.2\|WP_012281187.1\|266033_267656_+\|IS1182-like-element-ISHmo2-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.30853e-11
NC_010337.2\|WP_049754001.1\|273468_274521_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.87934e-93
NC_010337.2\|WP_012281414.1\|254486_257138_-\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NC_010337.2\|WP_012281418.1\|261721_263071_-\|dNTP-triphosphohydrolase	gnl\|CDD\|273571	TIGR01353, dGTP_triPase, deoxyguanosinetriphosphate triphosphohydrolase, putative. dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions].	5.13933e-105
NC_010337.2\|WP_012281420.1\|264600_264927_-\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	2.94443e-06
NC_010337.2\|WP_012281424.1\|273178_273466_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	4.52789e-19
NC_010337.2\|WP_012281423.1\|272564_273185_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	1.73373e-32
NC_010337.2\|WP_012281187.1\|268168_269791_+\|IS1182-like-element-ISHmo2-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.30853e-11
NC_010337.2\|WP_012281422.1\|271429_272362_-\|type-I-A-CRISPR-associated-protein-Cas4/Csa1	gnl\|CDD\|283640	pfam06023, Csa1, CRISPR-associated exonuclease Csa1. CRISPR (clustered regularly interspaced short palindromic repeats) elements and cas (CRISPR-associated) genes are widespread in Bacteria and Archaea. The CRISPR/Cas system operates as a defense mechanism against mobile genetic elements (i.e., viruses or plasmids). Csa1 is part of the archaeal subtype I-A system. Cas1 has not yet been enzymatically characterized.	1.61003e-79
NC_010337.2\|WP_012281416.1\|257537_258359_-\|sirohydrochlorin-cobaltochelatase	gnl\|CDD\|368778	pfam06180, CbiK, Cobalt chelatase (CbiK). This family consists of several bacterial cobalt chelatase (CbiK) proteins (EC:4.99.1.-).	9.64652e-87
NC_010337.2\|WP_012281187.1\|258531_260154_+\|IS1182-like-element-ISHmo2-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.30853e-11
NC_010337.2\|WP_012281413.1\|254045_254324_-\|IreB-family-regulatory-phosphoprotein	gnl\|CDD\|180108	PRK05473, IreB-like, IreB family regulatory phosphoprotein. IreB (EF1202) was characterized in Enterococcus faecalis as a small protein, well-conserved in the Firmicutes. It belongs to a system that includes the Ser/Thr protein kinase IreK, and phosphatase IreP, undergoes phosphorylation on threonine residues, and is involved in regulating cephalosporin resistance. This family was previously named DUF965 by Pfam model pfam06135.	1.57502e-52
NC_010337.2\|WP_012281429.1\|278375_279320_-\|DevR-family-CRISPR-associated-autoregulator	gnl\|CDD\|376656	pfam01905, DevR, CRISPR-associated negative auto-regulator DevR/Csa2. This group of families is one of several protein families that are always found associated with prokaryotic CRISPRs, themselves a family of clustered regularly interspaced short palindromic repeats, DNA repeats found in nearly half of all bacterial and archaeal genomes. These DNA repeat regions have a remarkably regular structure: unique sequences of constant size, called spacers, sit between each pair of repeats. It has been shown that the CRISPRs are virus-derived sequences acquired by the host to enable them to resist viral infection. The Cas proteins from the host use the CRISPRs to mediate an antiviral response. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation. Cas5 contains an endonuclease motif, whose inactivation leads to loss of resistance, even in the presence of phage-derived spacers. This family used to be known as DUF73. DevR appears to be negative auto-regulator within the system.	6.76156e-80
NC_010337.2\|WP_187147793.1\|276683_277505_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	gnl\|CDD\|337605	pfam10040, CRISPR_Cas6, CRISPR-associated endoribonuclease Cas6. Cas6 is a member of the RAMP (repeat-associated mysterious protein) superfamily. It is among the most widely distributed Cas proteins and is found in both bacteria and archaea. Cas6 functions in the generation of CRISPR-derived guide RNAs for invader defense in prokaryotes.	1.56923e-06

>NC_010337.2|WP_012281187.1|266033_267656_+|IS1182-like-element-ISHmo2-family-transposase
MFRFDVDPQVSFYDFAALWDQLVPADSVFRLFRELAPLLIQPEDFTGLYCLDNGRPSHAARQMTMACMLQEMLGETDRGMEAQTRVNIEVKFALGMALDEPGIDHANFGVHRQRLIQKELDKVYLDRFIRLMYYLGVLTGKEPWITDTTHVIAPISAPTTIELIRQAMRLLVRLLAKQYSVPWHAIPHAPRAVRYLETVTEVKEHNLDDKAKMERLVEVVSEADELLAYVESSEASWKKKPDVIHYALLLCRILRERIIRKDDGTLEIAPGGSVKDMIVSAVDSEARFGCKGKTKWRGYKMAIVEVGNSGFIAAAEAMKANDYDGSSLVPLADQLPTDCVENPTIIGDTHYGAGDDRVTLKEKGIDVVAPLSPKTKCDILAGEGFQVSEDQTQLICPRGKVITTYSEVADGKNFVLRAKDHDCKHCPRYTTCFKEKKHRRTIFIHNAYGVMLEAAKHSQTKIYKEQMRLRSRIEAKQNELVNRYGLRRVRRIGKRNLAYAARLSALAANFQKLNRLRNDKNATMVLEVSALRGVAFKKAA
>NC_010337.2|WP_148207154.1|265036_265741_+|transposase
MAETYGKITDVYTLDALFAKAPVIHAALDAGAHVVVRMKEERRRIMKEANACFANRLPDSTWEERDGKGNTVYVQAWDEEGLAQWPQVRVPMRIVKIIRHTNKTVIEANKEVFVTDVVERWIATTCSSEKADTQTIAQIAAARWDIENIGFRNLKTFNALDHCFVHDSVAIKAMIGFQVLAFNLKRLFFFHHLPASSRNRDVPLRYLIDEMREATRWLSLHLYRWVWEWGLSTA
>NC_010337.2|WP_012281420.1|264600_264927_-|transposase
MRRNRYPKELKEQLIQEAMEVGNATQVARRHGIDPKRLYYWIRESQHKGFQEAPAEAKQIAPYVPSAQEFKRLESENIALKKLLGEKTLEIQILQDLIKKKNPSYRKN
>NC_010337.2|WP_148207043.1|263665_264712_-|IS3-family-transposase
MGIRKHSTEKATRRKDIRNPNIARFNKKEEPELSEKLEVADEWVAREEASTAFILRVIGIHEATYYARRQRLQREPKERAYNGGRPQPGYSWTQDGKRISDEQIKEYLMELIAGEESVYGYRKLGLCLHKQHQLIINHKKTYRLCKELDILSPQRQIKAKHPRRMARNRTITASNELWEMDIKYGYIAGEDRFFYLMSLIDVYDRSIVDYHIGLNCEGADAANTLKRALWKRNCFEKEKKPIVRTDNGSQFISRVFEETCEQYQVEHERIPPKTPNKNAHIESFHANLERECYIKHAFESYQDAYQVVGEYIDFYNQRRIHGSLYNMSPAEFCRQLADGNVPAFIVTL
>NC_010337.2|WP_012281418.1|261721_263071_-|dNTP-triphosphohydrolase
MNDERKELPEFLGQIEDREKKLSELKEVTRKLLDEVSFFNDMRQSSVDMPSTQRSRHALERDYTRVLYSSSFRRLQGKMQLLGVSHEHFFRNRLTHSLEVAQIARSFAYEFGYSHEDIYAIEACALAHDIGNPPFGHSGERVLNEISKDFGGFEGNAQTLRVLTTLEKKIPDHGGLNLTYRTLLGTVKYYNQRSANKDKFIYDNDFQMINQLKGSRDFKLRTIDAQLMDLADEIAYAGHDLEDSLNLRLFTIDELQHELQLYFLENKLSDKEKELLLNTFSSIVENAKEKANKAKTSEEFNSIFIKEITSLLIHILMRDVTYAKISDDFKKKTGSENVMEFTFGQYGKLAKALKTITFRCIQRTDIVQQYELQGERIIRGLFEVLMDTKFNKDCHLMPPEFRKGHNNYCTRGRNVIDYISGMMDSYAIAAYKKLFGSHALSKLYWDQSH
>NC_010337.2|WP_041313043.1|261058_261655_-|hypothetical-protein
MNKLQGFYELRHIGIPAAPWNIFSKNTFLDPGLLWTIRVAVKTGDDINLPRAVGVTAEKAMEKGTQFLSQFGSNGIVIYYPYFIALKSGIMELKEKVTIIESVDGDLWNLTTKGRRAVTIFVDRLTHTVTEHGQKNFLNKKEIERLFRYGARVRVKYKDYIFNYTSVMVEWSLALNTNVNHMPVGDPYFVFYECRVVK
>NC_010337.2|WP_012281187.1|258531_260154_+|IS1182-like-element-ISHmo2-family-transposase
MFRFDVDPQVSFYDFAALWDQLVPADSVFRLFRELAPLLIQPEDFTGLYCLDNGRPSHAARQMTMACMLQEMLGETDRGMEAQTRVNIEVKFALGMALDEPGIDHANFGVHRQRLIQKELDKVYLDRFIRLMYYLGVLTGKEPWITDTTHVIAPISAPTTIELIRQAMRLLVRLLAKQYSVPWHAIPHAPRAVRYLETVTEVKEHNLDDKAKMERLVEVVSEADELLAYVESSEASWKKKPDVIHYALLLCRILRERIIRKDDGTLEIAPGGSVKDMIVSAVDSEARFGCKGKTKWRGYKMAIVEVGNSGFIAAAEAMKANDYDGSSLVPLADQLPTDCVENPTIIGDTHYGAGDDRVTLKEKGIDVVAPLSPKTKCDILAGEGFQVSEDQTQLICPRGKVITTYSEVADGKNFVLRAKDHDCKHCPRYTTCFKEKKHRRTIFIHNAYGVMLEAAKHSQTKIYKEQMRLRSRIEAKQNELVNRYGLRRVRRIGKRNLAYAARLSALAANFQKLNRLRNDKNATMVLEVSALRGVAFKKAA
>NC_010337.2|WP_012281416.1|257537_258359_-|sirohydrochlorin-cobaltochelatase
MVNAKAKADIPAILLVAFGTSAPEGRAALDHIEAKVKAAFPGVEVRWSYTSSMIRKKISREQQVFIDSPLTALAKLRDDGYNQVVVHSLHIFPGREYCDLEDIVRSLQAMKTSDGPVFDRLVLSDSLLHEFDDYRRACEAIAGLIPENSDEEALLLMGHGTDHRSLSVFGCLNDLLRHQYRGKNVMLATVEGYPKLQHALNDLAASGVKKVKVAPFLVVAGSHAQKDMAGDAPHSWKSRLEAKGYDVSLHMQGLGENDAIVEMMVDHLKKAWR
>NC_010337.2|WP_012281414.1|254486_257138_-|alanine--tRNA-ligase
MEFTGNRVRQLFLEYFEQKGHTIVASSSLVPHNDPTLLFSNAGMNQFKDVFLGFEKRPYLRATTSQKCVRAGGKHNDLDTVGRTARHHTFFEMLGNFSFGDYFKKDAIRYAWEFLTDVCGLPKDKLYATVYLDDDEAFALWRDMIGLPEARILRLGEKDNFWAMGDTGPCGPCSEILIDRGEHLRCKAEECAIGKCDCDRWLEIWNLVFMQYNRDENGTMTPLPRPSIDTGMGLERVTSVLQKVGSNYDTDLLRPLIAFVEQLCGQVYHRDDRGFPFRVIADHIRSCTFLITDGVLPSNEGRGYVLRRILRRAVRFGKVLGIDKPFMYEIVPVVVELMGEAYPDIREKQDFVCKVIKIEEERFHETLHDGMRIAADMVAKVKQEGGNVLPGKQAFTLYDTYGFPLDLAEDIAEENGLTVDKDGFQQAMEAQRERARAARQDTAYGAGMELWAELLQQLGPTVFTGYGRTSGESVVKAIVAGATRVTEAGAGTAVQVVLAETPFYAESGGQIGDSGLLRAGDAVVRVEDTKKMAGGLHVHFGVVAEGVFKEGDQVVAEVESARRLAIARHHSATHLMHKALKEVLGEHVNQAGSLVTPDRLRFDFSHFSPLTRDEWNRIEAAVNRAVFQALPVEVFETSIDEAKAMGATALFGEKYGDRVRVVRMGNYSMELCGGTHLDNTSQVGLCKLLSESGIGAGLRRIEAVTGEAALAYLNEQEETVRMLAEKLKVPAAEVTNRVDSLQAQLREKEREMEQLLSRLAKYQIDDLLAGKEEINGVTVLAAKVQAPDMDALRSMSDLLKEKLGSGVLILGAVAGDKVNLVAAATKDIVGRGVHAGNLVKEAAKVCGGGGGGRPDMAQAGGKDPSRLSDALEAAKKLLKSQIK
>NC_010337.2|WP_012281413.1|254045_254324_-|IreB-family-regulatory-phosphoprotein
MANETFDQTMMFLAKAEDELATSDILRTVYEALKEKGYNPINQLVGYLLSGDPAYITSHKNARSLIRRLERDDLLEELVRFYLESHDEEKAQ
>NC_010337.2|WP_012281187.1|268168_269791_+|IS1182-like-element-ISHmo2-family-transposase
MFRFDVDPQVSFYDFAALWDQLVPADSVFRLFRELAPLLIQPEDFTGLYCLDNGRPSHAARQMTMACMLQEMLGETDRGMEAQTRVNIEVKFALGMALDEPGIDHANFGVHRQRLIQKELDKVYLDRFIRLMYYLGVLTGKEPWITDTTHVIAPISAPTTIELIRQAMRLLVRLLAKQYSVPWHAIPHAPRAVRYLETVTEVKEHNLDDKAKMERLVEVVSEADELLAYVESSEASWKKKPDVIHYALLLCRILRERIIRKDDGTLEIAPGGSVKDMIVSAVDSEARFGCKGKTKWRGYKMAIVEVGNSGFIAAAEAMKANDYDGSSLVPLADQLPTDCVENPTIIGDTHYGAGDDRVTLKEKGIDVVAPLSPKTKCDILAGEGFQVSEDQTQLICPRGKVITTYSEVADGKNFVLRAKDHDCKHCPRYTTCFKEKKHRRTIFIHNAYGVMLEAAKHSQTKIYKEQMRLRSRIEAKQNELVNRYGLRRVRRIGKRNLAYAARLSALAANFQKLNRLRNDKNATMVLEVSALRGVAFKKAA
>NC_010337.2|WP_012281422.1|271429_272362_-|type-I-A-CRISPR-associated-protein-Cas4/Csa1
MYFLSDEERKKLLHYYLPKARREGVAEELRGWNWSQPPLSPVYDCPLGVFEVASGYCSSSRDVYLRRVEGARSKPNGAMFQGSLLHGLAARFIVATKGLIYQEGVDGYREILRKLQEMTLSELLDEGLVFELASLAEADREELERKSRLLLEFERGRLIARLQEALVKQPYIGEDALTALAVPVVVEQKLDGSFLGLSAHLSADAYNIGQPMIVEVKFGEPRDFHRLATAGYALVMEAVYEHPVDVGCLVCVTFKGDRVIIRRDIHLIDDELRQWFVEARDEKARMVYEEIDPGLAKDCPQSCPFANRCS
>NC_010337.2|WP_012281423.1|272564_273185_-|CRISPR-associated-protein-Cas4
MLTLRVTDVKQYVYCPRIPYFTYVQPLKPRPTAKMDFGKDAHARLDKLEKRRTLAAYPELEAGERKFHTYIHSARLGLEGKLDLHLVHRGEIFPVEFKSTSRRPGLNHKYQLTAYAMLLEELYQKPVRRGYFKLVNPLADGARPEKSEITLPVEITVPMRDFVKDVLRRIRAMVKQESLPSPKRPGNRCRDCEYRVYCLDLGDVVR
>NC_010337.2|WP_012281424.1|273178_273466_-|CRISPR-associated-endonuclease-Cas2
MKTLVIYDIELDKVRTKVSELCKDYGLQRIQYSAFFGELNTNRREELRQRIKKTLGRTVGRIHFFPICDKDLRLVMQVMNLPELLVDGDDGEASC
>NC_010337.2|WP_049754001.1|273468_274521_-|CRISPR-associated-endonuclease-Cas1
MKPLDLILDASESEKQHIIISQFGASLGKKSGRLVVREKGQVVTEVPFDRVEQVTVITSGASLSTDAIEECVRHGIEINLLDFRGSPYAKLFAPGLTATVKTRREQLLAFNDQRSIFLAKAFVRGKIQNQINTLKYFAKYRKSARQEVYAYLQDAALLMEKNLQELTGIDGLNIDAVRGPLMSVEGRAATRYWDAVAFLLKGYVVFPGRENRGATDPVNSLLNYGYAVLEARVLGAVLQAGLDPYAGFLHVDRPGKTSLVYDFIEEFRQPVIDRPVLAMVIAGVEIGMEGERLADGTKRDLLERIQQRLAATERFDGKKYPLQSILLRQARRMASYLRGDQKYKPFVCSW
>NC_010337.2|WP_012281426.1|274994_276356_+|transposase
MQSVAQPLEEVQKIFCRTPGGKKAGRLIQHFTQYASKVYGFSQMVRQAKDGRKQPRIKAPAIFTVAFFGAFFCMESMEQMDRWQKTGVFRQLVPKNIRLPSHDTVRQALMKWDLKEQRKQHNCVIQRYKEQRGPQKESINGWRVTAIDGVELFHTKAYRCPECLTREHRDKTTDYYHAVVVAQQVGGNANLIYDWEMRKPQDGVDKDEGETTVAQRLIRRMAETYGKITDVYTLDALFAKAPVIHAALDAGAHVVVRMKEERRRIMKEANACFANRLPDSTWEERDGKGNTVYVQAWDEEGLAQWPQVRVPMRIVKIIRHTNKTVIEANKEVFVTDVVERWIATTCSSEKADTQTIAQIAAARWDIENIGFRNLKTFNALDHCFVHDSVAIKAMIGFQVLAFNLKRLFFFHHLPASRHRDVPLRYLIDEMREATRWVSLHLYRWVWEWGLSTA
>NC_010337.2|WP_187147793.1|276683_277505_-|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6
MFQKVCLVTILFQPVAPERQEGFFGRAQELPPPFVLRPLTGGKTEWRPGETFELAVHLFGKGCDYAPYLLSALSVAMEGGLGKGKRPAKMVRVFGENPFTGESVAVFVDNQWRMDGAPTLGGKDVDQRVRDVLQNFDGKVTMEYVTPLRLKSDSRLQHSVDPVLFVRSVLRRLSLLSMFHGQGRWEFPFQEYIEHSSGLAFCDEHYSWVDWERYSSRQESRLKLGGIIGSASLEGEVLPSFLPLILWAELTHVGKSTVFGLGKIWIKNKHVVR
>NC_010337.2|WP_012281428.1|277653_278361_-|hypothetical-protein
MWLLAAFSASNLFSLKVSGATSSGGKSHLIPTPYVVKMALIDASFRLDGRGEEDFAWIRPLTIAFQVPEAVVVNNNFVKVLKEARDGDETYQQTVGLRQYVYWHGPIRIAFEIGGLSELQRERLSRLVTLVNYFGKRGSFVQYRGQEITAELEAGFSFDMNEPRKPGNGPLSREMLIQMMDDMGGSSGFDAFNSYSSSRQKLHEDRIFRPIVLVSVKEASSRGYTLYRALSPSPA
>NC_010337.2|WP_012281429.1|278375_279320_-|DevR-family-CRISPR-associated-autoregulator
MTISSISLCARVTLDMHSLNNEGAEGNQLQTRMVHIVDQTGQLAVTNAISGDMLKHIQNENLAQIASEMGLPICSGCKRVNANRINVDRDFFKSIEKLDTKDNIGTLRELIRYCTVDDLEGILITEGKRSVARKSVIEFGWLVGVPEKTRTESYFHVKFDAESRSGGSGSEDGSNTGQNIFYRPANSGEYALVLNVELDRIGFHDVTREYVLDEAERSKRKRAMLQSILHTFVKLNGAHRNTQHPHMVNMAGVISVSYNKTPAPTISPLADGYREEIQAVVQELNRWKGNEINCYKFDSLSQFARLVTDLAKKL
>NC_010337.2|WP_012281430.1|279354_281193_-|hypothetical-protein
MIVERFFVPHSTGTYADALEAVGLALLLDNLSGDSVSTIKDSGPYFEIQLNEPLILEELPVDQVLPYDPGYPYFMTAKDKNVPAGYLLYDYEEEKKIANTYWEQYKKQKAKKTATVTSDVAQTMQGAEPNPRHNLLKNMYVLQAFNSHNRLLSEFAAADPEAVKDAIIEKLRTYCHGCLKTLDAPDPIPKEAKRSSKAQRFAPDLTAVQALNPIVGKGINRNKPTGTGLAGLPSAYVDWFAEYLRYLAVHCIANAFNVGDDIKYAVLVPGEVSFNELKKLADDFVRLPLGKRTSCQLDIHNAIGLAEKLIDHSRQLQEHNERQTRWKLPKQVIAGIATAYFKSLGSGKALTNVNTIGLPGWFPIETIQDADDWKQILEEHRRIMYGLDEEHSEEAELLYQYRDFISSGQLKNLLDFAASYGAFVFKQAANQKRGYLGLSQRHLERLVTSLSKPFSDIVKDEGFRAIADAIRRSTVVEQYRKSQGRQEYEIRYGLFSDLKRKSRSKQELICLIGDFVSDYNKENARKEEVRAKKAVEKGAGELYRRPSVSDDAIEKVVALIDIFGSEPVAMLLAAFGSAKTETKKETKTDGKTETSVKTETSADTENGKDTGD

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Crispr_ID: NC_010337_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010337_2

269931-271232

Unclear

Consensus_repeat	Method
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CRISPRCasFinder
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CRT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	PILER-CR

17 spacers

cas4,cas2,cas1,cas6,cas5,cas7,cas8a4,cas3

The CRISPR arrays of NC_010337_2

>merge|NC_010337|2|269931-271232|CRISPRCasFinder,CRT,PILER-CR
CTAGACGGCCTCTACATAGCGGGTCATCCAGTGAAACTTGAACAGGAAGAAGGGGTGGGCCCCAACCGGGAGCCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACTTATCCATCGTTCCATCATTCATTCCGCCTCCCTGTACCCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACAGCGGCCGCCCGGTAAGCCCCCGGTTGCTGCCGTAGGCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACTGACAGCAAGTATGAAAGTGGTGGTGGAGATCGCTTTTCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACCTCAATCTGCTACCGAATAGCCCTTTTTCGGCTTTACCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACCATTGTCAGCCATTACACCACTTCCCCTCTGGGTTAAACTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACGATGGCATAGGTTCCCGTGGCTTGCGTGGGCACATGGGCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACTCTCTCTCTTAGCGTTAATCTTCTCGACCAAAGACTTCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACGCCCCGGCCCTCACGCTGTTTAGTAGGGATCCGGTTCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACGCGTTGGAGGATACCTCCTCGATAGACTGAGAAATCCTTCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACTGATTAAAGACCCCAAGGGAAAGGTACTTATTGATACTAACTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACGATCTTGGACACTCGTGCGGATCATTACCTTGAATCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACGTTGCGCCCGGCAGTTCCCTCAGGTCTGCCATGCAGTCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACCGCGATTATTCCATACTTGTCTCTGAGCATCTGATACCCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACTCGTTGATTTTCTGGTCGAGATGCCACAGTCGCTGTTCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACGTATTCTGCCGTCCTTGAGCACGATGAAATTCCCGCCGCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAACAGTAATCCCCGGTGTTCGTGGCCGCCGAGCGAGCCCCTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC

>NC_010337|2|2|269931-271232|CRISPRCasFinder
CTAGACGGCCTCTACATAGCGGGTCATCCAGTGAAAC	TTGAACAGGAAGAAGGGGTGGGCCCCAACCGGGAGC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TTATCCATCGTTCCATCATTCATTCCGCCTCCCTGTACC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	AGCGGCCGCCCGGTAAGCCCCCGGTTGCTGCCGTAGG
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TGACAGCAAGTATGAAAGTGGTGGTGGAGATCGCTTTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CTCAATCTGCTACCGAATAGCCCTTTTTCGGCTTTAC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CATTGTCAGCCATTACACCACTTCCCCTCTGGGTTAAA
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GATGGCATAGGTTCCCGTGGCTTGCGTGGGCACATGGG
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TCTCTCTCTTAGCGTTAATCTTCTCGACCAAAGACTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GCCCCGGCCCTCACGCTGTTTAGTAGGGATCCGGTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GCGTTGGAGGATACCTCCTCGATAGACTGAGAAATCCTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TGATTAAAGACCCCAAGGGAAAGGTACTTATTGATACTAA
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GATCTTGGACACTCGTGCGGATCATTACCTTGAAT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GTTGCGCCCGGCAGTTCCCTCAGGTCTGCCATGCAGT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CGCGATTATTCCATACTTGTCTCTGAGCATCTGATACC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TCGTTGATTTTCTGGTCGAGATGCCACAGTCGCTGTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GTATTCTGCCGTCCTTGAGCACGATGAAATTCCCGCCG
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	AGTAATCCCCGGTGTTCGTGGCCGCCGAGCGAGCCC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC

>NC_010337|2|1|269931-271232|CRT
CTAGACGGCCTCTACATAGCGGGTCATCCAGTGAAAC	TTGAACAGGAAGAAGGGGTGGGCCCCAACCGGGAGC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TTATCCATCGTTCCATCATTCATTCCGCCTCCCTGTACC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	AGCGGCCGCCCGGTAAGCCCCCGGTTGCTGCCGTAGG
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TGACAGCAAGTATGAAAGTGGTGGTGGAGATCGCTTTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CTCAATCTGCTACCGAATAGCCCTTTTTCGGCTTTAC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CATTGTCAGCCATTACACCACTTCCCCTCTGGGTTAAA
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GATGGCATAGGTTCCCGTGGCTTGCGTGGGCACATGGG
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TCTCTCTCTTAGCGTTAATCTTCTCGACCAAAGACTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GCCCCGGCCCTCACGCTGTTTAGTAGGGATCCGGTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GCGTTGGAGGATACCTCCTCGATAGACTGAGAAATCCTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TGATTAAAGACCCCAAGGGAAAGGTACTTATTGATACTAA
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GATCTTGGACACTCGTGCGGATCATTACCTTGAAT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GTTGCGCCCGGCAGTTCCCTCAGGTCTGCCATGCAGT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CGCGATTATTCCATACTTGTCTCTGAGCATCTGATACC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TCGTTGATTTTCTGGTCGAGATGCCACAGTCGCTGTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GTATTCTGCCGTCCTTGAGCACGATGAAATTCCCGCCG
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	AGTAATCCCCGGTGTTCGTGGCCGCCGAGCGAGCCC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC

>NC_010337|2|1|270004-271232|PILER-CR
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TTATCCATCGTTCCATCATTCATTCCGCCTCCCTGTACC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	AGCGGCCGCCCGGTAAGCCCCCGGTTGCTGCCGTAGG
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TGACAGCAAGTATGAAAGTGGTGGTGGAGATCGCTTTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CTCAATCTGCTACCGAATAGCCCTTTTTCGGCTTTAC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CATTGTCAGCCATTACACCACTTCCCCTCTGGGTTAAA
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GATGGCATAGGTTCCCGTGGCTTGCGTGGGCACATGGG
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TCTCTCTCTTAGCGTTAATCTTCTCGACCAAAGACTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GCCCCGGCCCTCACGCTGTTTAGTAGGGATCCGGTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GCGTTGGAGGATACCTCCTCGATAGACTGAGAAATCCTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TGATTAAAGACCCCAAGGGAAAGGTACTTATTGATACTAA
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GATCTTGGACACTCGTGCGGATCATTACCTTGAAT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GTTGCGCCCGGCAGTTCCCTCAGGTCTGCCATGCAGT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	CGCGATTATTCCATACTTGTCTCTGAGCATCTGATACC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	TCGTTGATTTTCTGGTCGAGATGCCACAGTCGCTGTT
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	GTATTCTGCCGTCCTTGAGCACGATGAAATTCCCGCCG
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC	AGTAATCCCCGGTGTTCGTGGCCGCCGAGCGAGCCC
CTTTCAATCCCCTACATAGCGGGTCATCCAGTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_010337.2\|WP_012281430.1\|279354_281193_-\|hypothetical-protein	cas8a4	cls000706_cas8a4_CAS-I-A	unknown
NC_010337.2\|WP_148207043.1\|263665_264712_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_010337.2\|WP_012281187.1\|268168_269791_+\|IS1182-like-element-ISHmo2-family-transposase	unknown	unknown	gnl\|CDD\|377531
NC_010337.2\|WP_041313043.1\|261058_261655_-\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012281414.1\|254486_257138_-\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NC_010337.2\|WP_012281431.1\|281182_283696_-\|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_010337.2\|WP_012281423.1\|272564_273185_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NC_010337.2\|WP_012281420.1\|264600_264927_-\|transposase	unknown	unknown	gnl\|CDD\|366690
NC_010337.2\|WP_012281424.1\|273178_273466_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NC_010337.2\|WP_012281418.1\|261721_263071_-\|dNTP-triphosphohydrolase	unknown	unknown	gnl\|CDD\|273571
NC_010337.2\|WP_012281187.1\|266033_267656_+\|IS1182-like-element-ISHmo2-family-transposase	unknown	unknown	gnl\|CDD\|377531
NC_010337.2\|WP_012281426.1\|274994_276356_+\|transposase	unknown	unknown	unknown
NC_010337.2\|WP_012281422.1\|271429_272362_-\|type-I-A-CRISPR-associated-protein-Cas4/Csa1	cas4	pfam06023_cas4_CAS-I	gnl\|CDD\|283640
NC_010337.2\|WP_012281416.1\|257537_258359_-\|sirohydrochlorin-cobaltochelatase	unknown	unknown	gnl\|CDD\|368778
NC_010337.2\|WP_049754001.1\|273468_274521_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187766
NC_010337.2\|WP_012281428.1\|277653_278361_-\|hypothetical-protein	cas5	cls000048_cas5_CAS-I-A	unknown
NC_010337.2\|WP_012281187.1\|258531_260154_+\|IS1182-like-element-ISHmo2-family-transposase	unknown	unknown	gnl\|CDD\|377531
NC_010337.2\|WP_148207154.1\|265036_265741_+\|transposase	unknown	unknown	unknown
NC_010337.2\|WP_012281429.1\|278375_279320_-\|DevR-family-CRISPR-associated-autoregulator	cas7	pfam01905_cas7_CAS-I	gnl\|CDD\|376656
NC_010337.2\|WP_187147793.1\|276683_277505_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	cas6	mkCas0066_cas6_CAS-I:CAS-III	gnl\|CDD\|337605

Protein	Function_ID	Function_description	E-value
NC_010337.2\|WP_148207043.1\|263665_264712_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	3.47253e-28
NC_010337.2\|WP_012281187.1\|268168_269791_+\|IS1182-like-element-ISHmo2-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.30853e-11
NC_010337.2\|WP_049754001.1\|273468_274521_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.87934e-93
NC_010337.2\|WP_012281414.1\|254486_257138_-\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NC_010337.2\|WP_012281431.1\|281182_283696_-\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.17583e-55
NC_010337.2\|WP_012281418.1\|261721_263071_-\|dNTP-triphosphohydrolase	gnl\|CDD\|273571	TIGR01353, dGTP_triPase, deoxyguanosinetriphosphate triphosphohydrolase, putative. dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions].	5.13933e-105
NC_010337.2\|WP_012281420.1\|264600_264927_-\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	2.94443e-06
NC_010337.2\|WP_012281424.1\|273178_273466_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	4.52789e-19
NC_010337.2\|WP_012281423.1\|272564_273185_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	1.73373e-32
NC_010337.2\|WP_012281187.1\|266033_267656_+\|IS1182-like-element-ISHmo2-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.30853e-11
NC_010337.2\|WP_012281422.1\|271429_272362_-\|type-I-A-CRISPR-associated-protein-Cas4/Csa1	gnl\|CDD\|283640	pfam06023, Csa1, CRISPR-associated exonuclease Csa1. CRISPR (clustered regularly interspaced short palindromic repeats) elements and cas (CRISPR-associated) genes are widespread in Bacteria and Archaea. The CRISPR/Cas system operates as a defense mechanism against mobile genetic elements (i.e., viruses or plasmids). Csa1 is part of the archaeal subtype I-A system. Cas1 has not yet been enzymatically characterized.	1.61003e-79
NC_010337.2\|WP_012281416.1\|257537_258359_-\|sirohydrochlorin-cobaltochelatase	gnl\|CDD\|368778	pfam06180, CbiK, Cobalt chelatase (CbiK). This family consists of several bacterial cobalt chelatase (CbiK) proteins (EC:4.99.1.-).	9.64652e-87
NC_010337.2\|WP_012281187.1\|258531_260154_+\|IS1182-like-element-ISHmo2-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.30853e-11
NC_010337.2\|WP_012281429.1\|278375_279320_-\|DevR-family-CRISPR-associated-autoregulator	gnl\|CDD\|376656	pfam01905, DevR, CRISPR-associated negative auto-regulator DevR/Csa2. This group of families is one of several protein families that are always found associated with prokaryotic CRISPRs, themselves a family of clustered regularly interspaced short palindromic repeats, DNA repeats found in nearly half of all bacterial and archaeal genomes. These DNA repeat regions have a remarkably regular structure: unique sequences of constant size, called spacers, sit between each pair of repeats. It has been shown that the CRISPRs are virus-derived sequences acquired by the host to enable them to resist viral infection. The Cas proteins from the host use the CRISPRs to mediate an antiviral response. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation. Cas5 contains an endonuclease motif, whose inactivation leads to loss of resistance, even in the presence of phage-derived spacers. This family used to be known as DUF73. DevR appears to be negative auto-regulator within the system.	6.76156e-80
NC_010337.2\|WP_187147793.1\|276683_277505_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	gnl\|CDD\|337605	pfam10040, CRISPR_Cas6, CRISPR-associated endoribonuclease Cas6. Cas6 is a member of the RAMP (repeat-associated mysterious protein) superfamily. It is among the most widely distributed Cas proteins and is found in both bacteria and archaea. Cas6 functions in the generation of CRISPR-derived guide RNAs for invader defense in prokaryotes.	1.56923e-06

>NC_010337.2|WP_012281187.1|268168_269791_+|IS1182-like-element-ISHmo2-family-transposase
MFRFDVDPQVSFYDFAALWDQLVPADSVFRLFRELAPLLIQPEDFTGLYCLDNGRPSHAARQMTMACMLQEMLGETDRGMEAQTRVNIEVKFALGMALDEPGIDHANFGVHRQRLIQKELDKVYLDRFIRLMYYLGVLTGKEPWITDTTHVIAPISAPTTIELIRQAMRLLVRLLAKQYSVPWHAIPHAPRAVRYLETVTEVKEHNLDDKAKMERLVEVVSEADELLAYVESSEASWKKKPDVIHYALLLCRILRERIIRKDDGTLEIAPGGSVKDMIVSAVDSEARFGCKGKTKWRGYKMAIVEVGNSGFIAAAEAMKANDYDGSSLVPLADQLPTDCVENPTIIGDTHYGAGDDRVTLKEKGIDVVAPLSPKTKCDILAGEGFQVSEDQTQLICPRGKVITTYSEVADGKNFVLRAKDHDCKHCPRYTTCFKEKKHRRTIFIHNAYGVMLEAAKHSQTKIYKEQMRLRSRIEAKQNELVNRYGLRRVRRIGKRNLAYAARLSALAANFQKLNRLRNDKNATMVLEVSALRGVAFKKAA
>NC_010337.2|WP_012281187.1|266033_267656_+|IS1182-like-element-ISHmo2-family-transposase
MFRFDVDPQVSFYDFAALWDQLVPADSVFRLFRELAPLLIQPEDFTGLYCLDNGRPSHAARQMTMACMLQEMLGETDRGMEAQTRVNIEVKFALGMALDEPGIDHANFGVHRQRLIQKELDKVYLDRFIRLMYYLGVLTGKEPWITDTTHVIAPISAPTTIELIRQAMRLLVRLLAKQYSVPWHAIPHAPRAVRYLETVTEVKEHNLDDKAKMERLVEVVSEADELLAYVESSEASWKKKPDVIHYALLLCRILRERIIRKDDGTLEIAPGGSVKDMIVSAVDSEARFGCKGKTKWRGYKMAIVEVGNSGFIAAAEAMKANDYDGSSLVPLADQLPTDCVENPTIIGDTHYGAGDDRVTLKEKGIDVVAPLSPKTKCDILAGEGFQVSEDQTQLICPRGKVITTYSEVADGKNFVLRAKDHDCKHCPRYTTCFKEKKHRRTIFIHNAYGVMLEAAKHSQTKIYKEQMRLRSRIEAKQNELVNRYGLRRVRRIGKRNLAYAARLSALAANFQKLNRLRNDKNATMVLEVSALRGVAFKKAA
>NC_010337.2|WP_148207154.1|265036_265741_+|transposase
MAETYGKITDVYTLDALFAKAPVIHAALDAGAHVVVRMKEERRRIMKEANACFANRLPDSTWEERDGKGNTVYVQAWDEEGLAQWPQVRVPMRIVKIIRHTNKTVIEANKEVFVTDVVERWIATTCSSEKADTQTIAQIAAARWDIENIGFRNLKTFNALDHCFVHDSVAIKAMIGFQVLAFNLKRLFFFHHLPASSRNRDVPLRYLIDEMREATRWLSLHLYRWVWEWGLSTA
>NC_010337.2|WP_012281420.1|264600_264927_-|transposase
MRRNRYPKELKEQLIQEAMEVGNATQVARRHGIDPKRLYYWIRESQHKGFQEAPAEAKQIAPYVPSAQEFKRLESENIALKKLLGEKTLEIQILQDLIKKKNPSYRKN
>NC_010337.2|WP_148207043.1|263665_264712_-|IS3-family-transposase
MGIRKHSTEKATRRKDIRNPNIARFNKKEEPELSEKLEVADEWVAREEASTAFILRVIGIHEATYYARRQRLQREPKERAYNGGRPQPGYSWTQDGKRISDEQIKEYLMELIAGEESVYGYRKLGLCLHKQHQLIINHKKTYRLCKELDILSPQRQIKAKHPRRMARNRTITASNELWEMDIKYGYIAGEDRFFYLMSLIDVYDRSIVDYHIGLNCEGADAANTLKRALWKRNCFEKEKKPIVRTDNGSQFISRVFEETCEQYQVEHERIPPKTPNKNAHIESFHANLERECYIKHAFESYQDAYQVVGEYIDFYNQRRIHGSLYNMSPAEFCRQLADGNVPAFIVTL
>NC_010337.2|WP_012281418.1|261721_263071_-|dNTP-triphosphohydrolase
MNDERKELPEFLGQIEDREKKLSELKEVTRKLLDEVSFFNDMRQSSVDMPSTQRSRHALERDYTRVLYSSSFRRLQGKMQLLGVSHEHFFRNRLTHSLEVAQIARSFAYEFGYSHEDIYAIEACALAHDIGNPPFGHSGERVLNEISKDFGGFEGNAQTLRVLTTLEKKIPDHGGLNLTYRTLLGTVKYYNQRSANKDKFIYDNDFQMINQLKGSRDFKLRTIDAQLMDLADEIAYAGHDLEDSLNLRLFTIDELQHELQLYFLENKLSDKEKELLLNTFSSIVENAKEKANKAKTSEEFNSIFIKEITSLLIHILMRDVTYAKISDDFKKKTGSENVMEFTFGQYGKLAKALKTITFRCIQRTDIVQQYELQGERIIRGLFEVLMDTKFNKDCHLMPPEFRKGHNNYCTRGRNVIDYISGMMDSYAIAAYKKLFGSHALSKLYWDQSH
>NC_010337.2|WP_041313043.1|261058_261655_-|hypothetical-protein
MNKLQGFYELRHIGIPAAPWNIFSKNTFLDPGLLWTIRVAVKTGDDINLPRAVGVTAEKAMEKGTQFLSQFGSNGIVIYYPYFIALKSGIMELKEKVTIIESVDGDLWNLTTKGRRAVTIFVDRLTHTVTEHGQKNFLNKKEIERLFRYGARVRVKYKDYIFNYTSVMVEWSLALNTNVNHMPVGDPYFVFYECRVVK
>NC_010337.2|WP_012281187.1|258531_260154_+|IS1182-like-element-ISHmo2-family-transposase
MFRFDVDPQVSFYDFAALWDQLVPADSVFRLFRELAPLLIQPEDFTGLYCLDNGRPSHAARQMTMACMLQEMLGETDRGMEAQTRVNIEVKFALGMALDEPGIDHANFGVHRQRLIQKELDKVYLDRFIRLMYYLGVLTGKEPWITDTTHVIAPISAPTTIELIRQAMRLLVRLLAKQYSVPWHAIPHAPRAVRYLETVTEVKEHNLDDKAKMERLVEVVSEADELLAYVESSEASWKKKPDVIHYALLLCRILRERIIRKDDGTLEIAPGGSVKDMIVSAVDSEARFGCKGKTKWRGYKMAIVEVGNSGFIAAAEAMKANDYDGSSLVPLADQLPTDCVENPTIIGDTHYGAGDDRVTLKEKGIDVVAPLSPKTKCDILAGEGFQVSEDQTQLICPRGKVITTYSEVADGKNFVLRAKDHDCKHCPRYTTCFKEKKHRRTIFIHNAYGVMLEAAKHSQTKIYKEQMRLRSRIEAKQNELVNRYGLRRVRRIGKRNLAYAARLSALAANFQKLNRLRNDKNATMVLEVSALRGVAFKKAA
>NC_010337.2|WP_012281416.1|257537_258359_-|sirohydrochlorin-cobaltochelatase
MVNAKAKADIPAILLVAFGTSAPEGRAALDHIEAKVKAAFPGVEVRWSYTSSMIRKKISREQQVFIDSPLTALAKLRDDGYNQVVVHSLHIFPGREYCDLEDIVRSLQAMKTSDGPVFDRLVLSDSLLHEFDDYRRACEAIAGLIPENSDEEALLLMGHGTDHRSLSVFGCLNDLLRHQYRGKNVMLATVEGYPKLQHALNDLAASGVKKVKVAPFLVVAGSHAQKDMAGDAPHSWKSRLEAKGYDVSLHMQGLGENDAIVEMMVDHLKKAWR
>NC_010337.2|WP_012281414.1|254486_257138_-|alanine--tRNA-ligase
MEFTGNRVRQLFLEYFEQKGHTIVASSSLVPHNDPTLLFSNAGMNQFKDVFLGFEKRPYLRATTSQKCVRAGGKHNDLDTVGRTARHHTFFEMLGNFSFGDYFKKDAIRYAWEFLTDVCGLPKDKLYATVYLDDDEAFALWRDMIGLPEARILRLGEKDNFWAMGDTGPCGPCSEILIDRGEHLRCKAEECAIGKCDCDRWLEIWNLVFMQYNRDENGTMTPLPRPSIDTGMGLERVTSVLQKVGSNYDTDLLRPLIAFVEQLCGQVYHRDDRGFPFRVIADHIRSCTFLITDGVLPSNEGRGYVLRRILRRAVRFGKVLGIDKPFMYEIVPVVVELMGEAYPDIREKQDFVCKVIKIEEERFHETLHDGMRIAADMVAKVKQEGGNVLPGKQAFTLYDTYGFPLDLAEDIAEENGLTVDKDGFQQAMEAQRERARAARQDTAYGAGMELWAELLQQLGPTVFTGYGRTSGESVVKAIVAGATRVTEAGAGTAVQVVLAETPFYAESGGQIGDSGLLRAGDAVVRVEDTKKMAGGLHVHFGVVAEGVFKEGDQVVAEVESARRLAIARHHSATHLMHKALKEVLGEHVNQAGSLVTPDRLRFDFSHFSPLTRDEWNRIEAAVNRAVFQALPVEVFETSIDEAKAMGATALFGEKYGDRVRVVRMGNYSMELCGGTHLDNTSQVGLCKLLSESGIGAGLRRIEAVTGEAALAYLNEQEETVRMLAEKLKVPAAEVTNRVDSLQAQLREKEREMEQLLSRLAKYQIDDLLAGKEEINGVTVLAAKVQAPDMDALRSMSDLLKEKLGSGVLILGAVAGDKVNLVAAATKDIVGRGVHAGNLVKEAAKVCGGGGGGRPDMAQAGGKDPSRLSDALEAAKKLLKSQIK
>NC_010337.2|WP_012281422.1|271429_272362_-|type-I-A-CRISPR-associated-protein-Cas4/Csa1
MYFLSDEERKKLLHYYLPKARREGVAEELRGWNWSQPPLSPVYDCPLGVFEVASGYCSSSRDVYLRRVEGARSKPNGAMFQGSLLHGLAARFIVATKGLIYQEGVDGYREILRKLQEMTLSELLDEGLVFELASLAEADREELERKSRLLLEFERGRLIARLQEALVKQPYIGEDALTALAVPVVVEQKLDGSFLGLSAHLSADAYNIGQPMIVEVKFGEPRDFHRLATAGYALVMEAVYEHPVDVGCLVCVTFKGDRVIIRRDIHLIDDELRQWFVEARDEKARMVYEEIDPGLAKDCPQSCPFANRCS
>NC_010337.2|WP_012281423.1|272564_273185_-|CRISPR-associated-protein-Cas4
MLTLRVTDVKQYVYCPRIPYFTYVQPLKPRPTAKMDFGKDAHARLDKLEKRRTLAAYPELEAGERKFHTYIHSARLGLEGKLDLHLVHRGEIFPVEFKSTSRRPGLNHKYQLTAYAMLLEELYQKPVRRGYFKLVNPLADGARPEKSEITLPVEITVPMRDFVKDVLRRIRAMVKQESLPSPKRPGNRCRDCEYRVYCLDLGDVVR
>NC_010337.2|WP_012281424.1|273178_273466_-|CRISPR-associated-endonuclease-Cas2
MKTLVIYDIELDKVRTKVSELCKDYGLQRIQYSAFFGELNTNRREELRQRIKKTLGRTVGRIHFFPICDKDLRLVMQVMNLPELLVDGDDGEASC
>NC_010337.2|WP_049754001.1|273468_274521_-|CRISPR-associated-endonuclease-Cas1
MKPLDLILDASESEKQHIIISQFGASLGKKSGRLVVREKGQVVTEVPFDRVEQVTVITSGASLSTDAIEECVRHGIEINLLDFRGSPYAKLFAPGLTATVKTRREQLLAFNDQRSIFLAKAFVRGKIQNQINTLKYFAKYRKSARQEVYAYLQDAALLMEKNLQELTGIDGLNIDAVRGPLMSVEGRAATRYWDAVAFLLKGYVVFPGRENRGATDPVNSLLNYGYAVLEARVLGAVLQAGLDPYAGFLHVDRPGKTSLVYDFIEEFRQPVIDRPVLAMVIAGVEIGMEGERLADGTKRDLLERIQQRLAATERFDGKKYPLQSILLRQARRMASYLRGDQKYKPFVCSW
>NC_010337.2|WP_012281426.1|274994_276356_+|transposase
MQSVAQPLEEVQKIFCRTPGGKKAGRLIQHFTQYASKVYGFSQMVRQAKDGRKQPRIKAPAIFTVAFFGAFFCMESMEQMDRWQKTGVFRQLVPKNIRLPSHDTVRQALMKWDLKEQRKQHNCVIQRYKEQRGPQKESINGWRVTAIDGVELFHTKAYRCPECLTREHRDKTTDYYHAVVVAQQVGGNANLIYDWEMRKPQDGVDKDEGETTVAQRLIRRMAETYGKITDVYTLDALFAKAPVIHAALDAGAHVVVRMKEERRRIMKEANACFANRLPDSTWEERDGKGNTVYVQAWDEEGLAQWPQVRVPMRIVKIIRHTNKTVIEANKEVFVTDVVERWIATTCSSEKADTQTIAQIAAARWDIENIGFRNLKTFNALDHCFVHDSVAIKAMIGFQVLAFNLKRLFFFHHLPASRHRDVPLRYLIDEMREATRWVSLHLYRWVWEWGLSTA
>NC_010337.2|WP_187147793.1|276683_277505_-|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6
MFQKVCLVTILFQPVAPERQEGFFGRAQELPPPFVLRPLTGGKTEWRPGETFELAVHLFGKGCDYAPYLLSALSVAMEGGLGKGKRPAKMVRVFGENPFTGESVAVFVDNQWRMDGAPTLGGKDVDQRVRDVLQNFDGKVTMEYVTPLRLKSDSRLQHSVDPVLFVRSVLRRLSLLSMFHGQGRWEFPFQEYIEHSSGLAFCDEHYSWVDWERYSSRQESRLKLGGIIGSASLEGEVLPSFLPLILWAELTHVGKSTVFGLGKIWIKNKHVVR
>NC_010337.2|WP_012281428.1|277653_278361_-|hypothetical-protein
MWLLAAFSASNLFSLKVSGATSSGGKSHLIPTPYVVKMALIDASFRLDGRGEEDFAWIRPLTIAFQVPEAVVVNNNFVKVLKEARDGDETYQQTVGLRQYVYWHGPIRIAFEIGGLSELQRERLSRLVTLVNYFGKRGSFVQYRGQEITAELEAGFSFDMNEPRKPGNGPLSREMLIQMMDDMGGSSGFDAFNSYSSSRQKLHEDRIFRPIVLVSVKEASSRGYTLYRALSPSPA
>NC_010337.2|WP_012281429.1|278375_279320_-|DevR-family-CRISPR-associated-autoregulator
MTISSISLCARVTLDMHSLNNEGAEGNQLQTRMVHIVDQTGQLAVTNAISGDMLKHIQNENLAQIASEMGLPICSGCKRVNANRINVDRDFFKSIEKLDTKDNIGTLRELIRYCTVDDLEGILITEGKRSVARKSVIEFGWLVGVPEKTRTESYFHVKFDAESRSGGSGSEDGSNTGQNIFYRPANSGEYALVLNVELDRIGFHDVTREYVLDEAERSKRKRAMLQSILHTFVKLNGAHRNTQHPHMVNMAGVISVSYNKTPAPTISPLADGYREEIQAVVQELNRWKGNEINCYKFDSLSQFARLVTDLAKKL
>NC_010337.2|WP_012281430.1|279354_281193_-|hypothetical-protein
MIVERFFVPHSTGTYADALEAVGLALLLDNLSGDSVSTIKDSGPYFEIQLNEPLILEELPVDQVLPYDPGYPYFMTAKDKNVPAGYLLYDYEEEKKIANTYWEQYKKQKAKKTATVTSDVAQTMQGAEPNPRHNLLKNMYVLQAFNSHNRLLSEFAAADPEAVKDAIIEKLRTYCHGCLKTLDAPDPIPKEAKRSSKAQRFAPDLTAVQALNPIVGKGINRNKPTGTGLAGLPSAYVDWFAEYLRYLAVHCIANAFNVGDDIKYAVLVPGEVSFNELKKLADDFVRLPLGKRTSCQLDIHNAIGLAEKLIDHSRQLQEHNERQTRWKLPKQVIAGIATAYFKSLGSGKALTNVNTIGLPGWFPIETIQDADDWKQILEEHRRIMYGLDEEHSEEAELLYQYRDFISSGQLKNLLDFAASYGAFVFKQAANQKRGYLGLSQRHLERLVTSLSKPFSDIVKDEGFRAIADAIRRSTVVEQYRKSQGRQEYEIRYGLFSDLKRKSRSKQELICLIGDFVSDYNKENARKEEVRAKKAVEKGAGELYRRPSVSDDAIEKVVALIDIFGSEPVAMLLAAFGSAKTETKKETKTDGKTETSVKTETSADTENGKDTGD
>NC_010337.2|WP_012281431.1|281182_283696_-|CRISPR-associated-helicase-Cas3'
MQPELTALFTQITGKKPYGFQTQVAREVLEQERVILRAPTGSGKTWAALLPFLYAKENRTPWADRLIYAVPLRTLGKNLYSTIKKRLDDQFPGKYRVTMQTGDVPDDPLFEGDIILCTVDQLLSAYILHPYAVGPRRANVVAGALSGAYVVIDETHLLTPRESLATAVDMVRRYQGLMTALFMTATMPDTVMDEVARRCKAKTITVTEEQMESDPQSRQVKPERRIHRMTIPLSPEAVLSEHRTSSLVVCNTVDRAVRFYQTLKKMLGENKSDIPLFLLHSRFLPEDRARLERRITEQFGPDRTGRGIIISTQVLEAGVDISADVLHTELAPANAIVQRSGRVARYGGLGSIFVYDITEDGKRNYAPYFGVSIAANASSATNDINASSDEAEARRIMDATWDSLEKWDGKVIGFTQELAWVNEIHAAVEQRALRSRTERKVIDDVNAAMRSQSSHFLRDLVRNAASINLLVHPDPNTLDMRRQPPLFSLHPGVFRRIVRRVLRGEQDGAMWFMDFRENDEIIWMEIKNEKDLDGRYFFAVSPQLAAYHPEIGLTMESGTFQCKEKLDKPPVYERFRYRKELLSDHLQAVAGECEQQGKRNQAAVARWAELLCLRTDTIESFSWLGAAGHDAGKASLQWQTWARNYQFVLTGKVEEECLAHTDYDPENPRVKEAEKSKRKPSHAAEGAYYLFDRLLQPVADGLIPDDLPKAEIIARSVMTAIARHHGPHVKELNRQIEFCGMPDAVANWLSEQVKTMPVDTAILENIGLQSAWKSESSFDRNRFAKLLVDPKLNECGNNVLKELAWLFYLYLVRRLRMADWASMERAHPEKEVEKGDC

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Crispr_ID: NC_010337_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010337_3

602509-603596

TypeI-E

I-C,I-E,II-B

Consensus_repeat	Method
CGGTACACCCCCGCGCACGCGGGGAACAT	PILER-CR
CGGTACACCCCCGCGCACGCGGGGAACAT	CRISPRCasFinder
CGGTACACCCCCGCGCACGCGGGGAACAT	CRT

17 spacers

cas3,cas8e,cse2gr11,cas7,cas5,cas6e,cas1,RT

The CRISPR arrays of NC_010337_3

>merge|NC_010337|3|602509-603596|PILER-CR,CRISPRCasFinder,CRT
CGGTACACCCCCGCACACGCGGGGAACATCCAATAAGGGAAGACGGGGGTTTCTCGCTGCCTTACGGTACACCCCCGCGCACGCGGGGAACATGGGAATGGGGTGACCTGTCTGCCGCCCAGTATGTCCGGTACACCCCCGCGCACGCGGGGAACATCTCAAAGTGCCCACCGTATCGTTCCGCTTCAGGCGGTACACCCCCGCGCACGCGGGGAACATGTTTGAGGAGGTTGTCGAGGTCAAGTGCAAATCGGTACACCCCCGCGCACGCGGGGAACATTACTGCTCCACCTCGGGCGTCAATCCTTGCGCTTCCGGTACACCCCCGCGCACGCGGGGAACATATAAATGGGCCTCATGAAGGATCGTTTAACCTCGGTACACCCCCGCGCACGCGGGGAACATGGCAGTCCACTAACCACAGAGCATTCTGTCTTTACGGTACACCCCCGCGCACGCGGGGAACATTCCCGTCCAAACTTTCGGTCGAATCCTACTTGCGGTACACCCCCGCGCACGCGGGGAACATGTTGCCGTTGAGAACAAGGTTGGCGAGGGCTTCCGGTACACCCCCGCGCACGCGGGGAACATGGACCCTTCCCTTCCGTCTCCTTGCCCTCCAGCGGTACACCCCCGCGCACGCGGGGAACATGCCGGGCCGGTGAATCGGCCGTTGCTGGATGTCGGTACACCCCCGCGCACGCGGGGAACATGCGAACAACCGGGCTGAGGCGGGGTTTGAAGTCTACGGTACACCCCAGCGCACGCGGGGAACATCCGAAAGTCCCAAAATCTACAACATCGACCTTCGGTACACCCCCGCGCACGCGGGGAACATTTCAAAGGGTAAATGGGCCGGCAAGCCACTACTCCGGTACACCCCCGCGCACGCGGGGAACATGATTATCCCGACAACCGTTCCGCCGGTTCCCGAGCGGTACACCCCCGCGCACGCGGGGAACATGCTGCTTTCCTTCCCCGGCCGCTAGCTTTGCGACGGTACACCCCCGCGCACGCGGGGAACATGGTACGAGACTTGTTCTCGACCTTCGACGAGGACGGTACACCCCCGCGCACGCGGGGAACAT

>NC_010337|3|2|602509-603596|PILER-CR
CGGTACACCCCCGCACACGCGGGGAACAT	CCAATAAGGGAAGACGGGGGTTTCTCGCTGCCTTA
CGGTACACCCCCGCGCACGCGGGGAACAT	GGGAATGGGGTGACCTGTCTGCCGCCCAGTATGTC
CGGTACACCCCCGCGCACGCGGGGAACAT	CTCAAAGTGCCCACCGTATCGTTCCGCTTCAGG
CGGTACACCCCCGCGCACGCGGGGAACAT	GTTTGAGGAGGTTGTCGAGGTCAAGTGCAAAT
CGGTACACCCCCGCGCACGCGGGGAACAT	TACTGCTCCACCTCGGGCGTCAATCCTTGCGCTTC
CGGTACACCCCCGCGCACGCGGGGAACAT	ATAAATGGGCCTCATGAAGGATCGTTTAACCT
CGGTACACCCCCGCGCACGCGGGGAACAT	GGCAGTCCACTAACCACAGAGCATTCTGTCTTTA
CGGTACACCCCCGCGCACGCGGGGAACAT	TCCCGTCCAAACTTTCGGTCGAATCCTACTTG
CGGTACACCCCCGCGCACGCGGGGAACAT	GTTGCCGTTGAGAACAAGGTTGGCGAGGGCTTC
CGGTACACCCCCGCGCACGCGGGGAACAT	GGACCCTTCCCTTCCGTCTCCTTGCCCTCCAG
CGGTACACCCCCGCGCACGCGGGGAACAT	GCCGGGCCGGTGAATCGGCCGTTGCTGGATGT
CGGTACACCCCCGCGCACGCGGGGAACAT	GCGAACAACCGGGCTGAGGCGGGGTTTGAAGTCTA
CGGTACACCCCAGCGCACGCGGGGAACAT	CCGAAAGTCCCAAAATCTACAACATCGACCTT
CGGTACACCCCCGCGCACGCGGGGAACAT	TTCAAAGGGTAAATGGGCCGGCAAGCCACTACTC
CGGTACACCCCCGCGCACGCGGGGAACAT	GATTATCCCGACAACCGTTCCGCCGGTTCCCGAG
CGGTACACCCCCGCGCACGCGGGGAACAT	GCTGCTTTCCTTCCCCGGCCGCTAGCTTTGCGA
CGGTACACCCCCGCGCACGCGGGGAACAT	GGTACGAGACTTGTTCTCGACCTTCGACGAGGA
CGGTACACCCCCGCGCACGCGGGGAACAT

>NC_010337|3|3|602509-603596|CRISPRCasFinder
CGGTACACCCCCGCACACGCGGGGAACAT	CCAATAAGGGAAGACGGGGGTTTCTCGCTGCCTTA
CGGTACACCCCCGCGCACGCGGGGAACAT	GGGAATGGGGTGACCTGTCTGCCGCCCAGTATGTC
CGGTACACCCCCGCGCACGCGGGGAACAT	CTCAAAGTGCCCACCGTATCGTTCCGCTTCAGG
CGGTACACCCCCGCGCACGCGGGGAACAT	GTTTGAGGAGGTTGTCGAGGTCAAGTGCAAAT
CGGTACACCCCCGCGCACGCGGGGAACAT	TACTGCTCCACCTCGGGCGTCAATCCTTGCGCTTC
CGGTACACCCCCGCGCACGCGGGGAACAT	ATAAATGGGCCTCATGAAGGATCGTTTAACCT
CGGTACACCCCCGCGCACGCGGGGAACAT	GGCAGTCCACTAACCACAGAGCATTCTGTCTTTA
CGGTACACCCCCGCGCACGCGGGGAACAT	TCCCGTCCAAACTTTCGGTCGAATCCTACTTG
CGGTACACCCCCGCGCACGCGGGGAACAT	GTTGCCGTTGAGAACAAGGTTGGCGAGGGCTTC
CGGTACACCCCCGCGCACGCGGGGAACAT	GGACCCTTCCCTTCCGTCTCCTTGCCCTCCAG
CGGTACACCCCCGCGCACGCGGGGAACAT	GCCGGGCCGGTGAATCGGCCGTTGCTGGATGT
CGGTACACCCCCGCGCACGCGGGGAACAT	GCGAACAACCGGGCTGAGGCGGGGTTTGAAGTCTA
CGGTACACCCCAGCGCACGCGGGGAACAT	CCGAAAGTCCCAAAATCTACAACATCGACCTT
CGGTACACCCCCGCGCACGCGGGGAACAT	TTCAAAGGGTAAATGGGCCGGCAAGCCACTACTC
CGGTACACCCCCGCGCACGCGGGGAACAT	GATTATCCCGACAACCGTTCCGCCGGTTCCCGAG
CGGTACACCCCCGCGCACGCGGGGAACAT	GCTGCTTTCCTTCCCCGGCCGCTAGCTTTGCGA
CGGTACACCCCCGCGCACGCGGGGAACAT	GGTACGAGACTTGTTCTCGACCTTCGACGAGGA
CGGTACACCCCCGCGCACGCGGGGAACAT

>NC_010337|3|2|602509-603596|CRT
CGGTACACCCCCGCACACGCGGGGAACAT	CCAATAAGGGAAGACGGGGGTTTCTCGCTGCCTTA
CGGTACACCCCCGCGCACGCGGGGAACAT	GGGAATGGGGTGACCTGTCTGCCGCCCAGTATGTC
CGGTACACCCCCGCGCACGCGGGGAACAT	CTCAAAGTGCCCACCGTATCGTTCCGCTTCAGG
CGGTACACCCCCGCGCACGCGGGGAACAT	GTTTGAGGAGGTTGTCGAGGTCAAGTGCAAAT
CGGTACACCCCCGCGCACGCGGGGAACAT	TACTGCTCCACCTCGGGCGTCAATCCTTGCGCTTC
CGGTACACCCCCGCGCACGCGGGGAACAT	ATAAATGGGCCTCATGAAGGATCGTTTAACCT
CGGTACACCCCCGCGCACGCGGGGAACAT	GGCAGTCCACTAACCACAGAGCATTCTGTCTTTA
CGGTACACCCCCGCGCACGCGGGGAACAT	TCCCGTCCAAACTTTCGGTCGAATCCTACTTG
CGGTACACCCCCGCGCACGCGGGGAACAT	GTTGCCGTTGAGAACAAGGTTGGCGAGGGCTTC
CGGTACACCCCCGCGCACGCGGGGAACAT	GGACCCTTCCCTTCCGTCTCCTTGCCCTCCAG
CGGTACACCCCCGCGCACGCGGGGAACAT	GCCGGGCCGGTGAATCGGCCGTTGCTGGATGT
CGGTACACCCCCGCGCACGCGGGGAACAT	GCGAACAACCGGGCTGAGGCGGGGTTTGAAGTCTA
CGGTACACCCCAGCGCACGCGGGGAACAT	CCGAAAGTCCCAAAATCTACAACATCGACCTT
CGGTACACCCCCGCGCACGCGGGGAACAT	TTCAAAGGGTAAATGGGCCGGCAAGCCACTACTC
CGGTACACCCCCGCGCACGCGGGGAACAT	GATTATCCCGACAACCGTTCCGCCGGTTCCCGAG
CGGTACACCCCCGCGCACGCGGGGAACAT	GCTGCTTTCCTTCCCCGGCCGCTAGCTTTGCGA
CGGTACACCCCCGCGCACGCGGGGAACAT	GGTACGAGACTTGTTCTCGACCTTCGACGAGGA
CGGTACACCCCCGCGCACGCGGGGAACAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_010337.2\|WP_012281204.1\|608222_609650_-\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209
NC_010337.2\|WP_041313175.1\|598330_598546_+\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012281746.1\|590402_591335_-\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NC_010337.2\|WP_041313172.1\|591337_592024_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl\|CDD\|378050
NC_010337.2\|WP_148207064.1\|595993_598147_-\|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031
NC_010337.2\|WP_012281762.1\|614017_615157_-\|sporulation-protein-YhbH	unknown	unknown	gnl\|CDD\|274336
NC_010337.2\|WP_012281755.1\|605845_606634_-\|P-loop-NTPase	unknown	unknown	gnl\|CDD\|349757
NC_010337.2\|WP_049754214.1\|606797_607406_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_010337.2\|WP_012281763.1\|615169_617065_-\|PrkA-family-serine-protein-kinase	unknown	unknown	gnl\|CDD\|225357
NC_010337.2\|WP_012281426.1\|600852_602214_-\|transposase	unknown	unknown	unknown
NC_010337.2\|WP_012281760.1\|611836_612946_-\|HD-GYP-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NC_010337.2\|WP_148207065.1\|610083_610947_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270407
NC_010337.2\|WP_041313177.1\|611043_611778_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_010337.2\|WP_012281747.1\|592010_592703_-\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl\|CDD\|273842
NC_010337.2\|WP_012281750.1\|594438_596010_-\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09729_cas8e_CAS-I-E	gnl\|CDD\|378189
NC_010337.2\|WP_012281757.1\|607475_608129_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_010337.2\|WP_049754013.1\|592705_593866_-\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NC_010337.2\|WP_012281187.1\|598683_600306_+\|IS1182-like-element-ISHmo2-family-transposase	unknown	unknown	gnl\|CDD\|377531
NC_010337.2\|WP_012281749.1\|593865_594429_-\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09731_cse2gr11_CAS-I-E	gnl\|CDD\|378191
NC_010337.2\|WP_012281761.1\|613376_613817_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341404

Protein	Function_ID	Function_description	E-value
NC_010337.2\|WP_012281204.1\|608222_609650_-\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	0
NC_010337.2\|WP_041313177.1\|611043_611778_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	5.47416e-164
NC_010337.2\|WP_012281746.1\|590402_591335_-\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	1.83774e-145
NC_010337.2\|WP_041313172.1\|591337_592024_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	1.09864e-62
NC_010337.2\|WP_148207064.1\|595993_598147_-\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	2.07942e-84
NC_010337.2\|WP_012281762.1\|614017_615157_-\|sporulation-protein-YhbH	gnl\|CDD\|274336	TIGR02877, Stress_response_UPF0229_protein_YhbH, sporulation protein YhbH. This protein family, typified by YhbH in Bacillus subtilis, is found in nearly every endospore-forming bacterium and in no other genome (but note that the trusted cutoff score is set high to exclude a single high-scoring sequence from Nitrosococcus oceani ATCC 19707, which is classified in the Gammaproteobacteria). The gene in Bacillus subtilis was shown to be in the regulon of the sporulation sigma factor, sigma-E, and its mutation was shown to create a sporulation defect. [Cellular processes, Sporulation and germination].	0
NC_010337.2\|WP_148207065.1\|610083_610947_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270407	cd13689, PBP2_BsGlnH, Substrate binding domain of ABC glutamine transporter from Bacillus subtilis; the type 2 periplasmic-bindig protein fold. This group includes periplasmic glutamine-binding domain GlnP from Bacillus subtilis and its related proteins. The GlnP domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	9.5181e-104
NC_010337.2\|WP_049754214.1\|606797_607406_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	6.71349e-73
NC_010337.2\|WP_012281763.1\|615169_617065_-\|PrkA-family-serine-protein-kinase	gnl\|CDD\|225357	COG2766, PrkA, Putative Ser protein kinase [Signal transduction mechanisms].	0
NC_010337.2\|WP_012281760.1\|611836_612946_-\|HD-GYP-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	2.26316e-59
NC_010337.2\|WP_012281761.1\|613376_613817_+\|CBS-domain-containing-protein	gnl\|CDD\|341404	cd09834, CBS_pair_bac, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	4.14838e-70
NC_010337.2\|WP_012281747.1\|592010_592703_-\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|273842	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.	1.12179e-41
NC_010337.2\|WP_012281755.1\|605845_606634_-\|P-loop-NTPase	gnl\|CDD\|349757	cd02037, Mrp_NBP35, Mrp/NBP35 ATP-binding protein family. Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.	1.38271e-45
NC_010337.2\|WP_012281757.1\|607475_608129_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.80252e-81
NC_010337.2\|WP_049754013.1\|592705_593866_-\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	1.94113e-131
NC_010337.2\|WP_012281187.1\|598683_600306_+\|IS1182-like-element-ISHmo2-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.30853e-11
NC_010337.2\|WP_012281749.1\|593865_594429_-\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	6.43934e-25
NC_010337.2\|WP_012281750.1\|594438_596010_-\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|378189	pfam09481, CRISPR_Cse1, CRISPR-associated protein Cse1 (CRISPR_cse1). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	2.96818e-93

>NC_010337.2|WP_012281426.1|600852_602214_-|transposase
MQSVAQPLEEVQKIFCRTPGGKKAGRLIQHFTQYASKVYGFSQMVRQAKDGRKQPRIKAPAIFTVAFFGAFFCMESMEQMDRWQKTGVFRQLVPKNIRLPSHDTVRQALMKWDLKEQRKQHNCVIQRYKEQRGPQKESINGWRVTAIDGVELFHTKAYRCPECLTREHRDKTTDYYHAVVVAQQVGGNANLIYDWEMRKPQDGVDKDEGETTVAQRLIRRMAETYGKITDVYTLDALFAKAPVIHAALDAGAHVVVRMKEERRRIMKEANACFANRLPDSTWEERDGKGNTVYVQAWDEEGLAQWPQVRVPMRIVKIIRHTNKTVIEANKEVFVTDVVERWIATTCSSEKADTQTIAQIAAARWDIENIGFRNLKTFNALDHCFVHDSVAIKAMIGFQVLAFNLKRLFFFHHLPASRHRDVPLRYLIDEMREATRWVSLHLYRWVWEWGLSTA
>NC_010337.2|WP_012281187.1|598683_600306_+|IS1182-like-element-ISHmo2-family-transposase
MFRFDVDPQVSFYDFAALWDQLVPADSVFRLFRELAPLLIQPEDFTGLYCLDNGRPSHAARQMTMACMLQEMLGETDRGMEAQTRVNIEVKFALGMALDEPGIDHANFGVHRQRLIQKELDKVYLDRFIRLMYYLGVLTGKEPWITDTTHVIAPISAPTTIELIRQAMRLLVRLLAKQYSVPWHAIPHAPRAVRYLETVTEVKEHNLDDKAKMERLVEVVSEADELLAYVESSEASWKKKPDVIHYALLLCRILRERIIRKDDGTLEIAPGGSVKDMIVSAVDSEARFGCKGKTKWRGYKMAIVEVGNSGFIAAAEAMKANDYDGSSLVPLADQLPTDCVENPTIIGDTHYGAGDDRVTLKEKGIDVVAPLSPKTKCDILAGEGFQVSEDQTQLICPRGKVITTYSEVADGKNFVLRAKDHDCKHCPRYTTCFKEKKHRRTIFIHNAYGVMLEAAKHSQTKIYKEQMRLRSRIEAKQNELVNRYGLRRVRRIGKRNLAYAARLSALAANFQKLNRLRNDKNATMVLEVSALRGVAFKKAA
>NC_010337.2|WP_041313175.1|598330_598546_+|hypothetical-protein
MANVDARGMWEKLSFNPILDNGQPYAFYLKLRMTLSNIMHSSEKSSANNRFFFRPTGSTLQFVDQTGKWAT
>NC_010337.2|WP_148207064.1|595993_598147_-|CRISPR-associated-helicase-Cas3'
MEELLRFFQMDIWKQQDFPDHSTFGMLLSGITVLADWIASSEAFFGGDIPDWHQAKQKNFEVLALQFLDQVGLSGKKPINAEMTEEDSFLRFWRHLHLPSLRPLQALCEQIARSEKTGGLAIIEAPMGEGKSEAGIYLLNCWVAGSGGDGMYVALPTAATANQMYSRVQELLSNQGTEKGLRLVHGMAWLLDLQKQYWEEDEREDWFRPKKRALLAPYGVGTVDQAMLAAMRVKFGCLRLLGLAGKGLLIDEVHAYDTYMNTIIDQLLAWCGHLSIPVVLLSATLPVKRRKQLLEAYGGDVIEGAVNQQYPLVTVAVDAKTCEFPVLPSRPNQEYNLRMLPGALENAEAIVNAVLDWADAHDSGCAGVVVNTVYMAQQVFRKLKKLHRKGRLPSDVELLLYHARFTAGRRKAIEDKVLRWLDKGSLQDPARRPKRAVLVATQVVEQSLDIDFDVLFTELAPIDLLLQRIGRLWRHERPRRLNHAESKANVSIFAPEIAERFYWGKTGAVYEPLVLLKTLAVLQKRNQFQLPQDFRPLIESVYDDEIANVPDEWLYSLASVREEYRKNQVEQQQRARESLYPKPLKSELAVTPIFAVNEEVSEGEVSSHLHAVTRIGSETRSVLAVPKDEWERVGQGLVSHEQLHHWMKYHVSLPEKWLSGCELPALKPYRQWSVMPMHPGSPSFWEGTSKGGNVIRIEYDDELGFRLGKEEPNATSL
>NC_010337.2|WP_012281750.1|594438_596010_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MQPAFDLLTEPWVTVRDVKGRICVVHLRDVLAKAHEWSEVIDESPLIQFGLYRFLQALIIDIFPLKGQRGRLELMEEGQFDETKLNAYWEKYGVYFDLFDAERPFLQVPPREQEKVKRKSVAELFHQLPTGTNVIHFHHRLQDEYVLAPDVCARIMTTLSPFTTAGGQGLSPSINGNPPYYVWRKGDNLFETLLLNYWITDQDRGIPAWRDRRPSRGETRSEARLLEGLTWQPRRVTLIPEMGPFQCTYSGRSCQWGVRQMVFEAGFQARVDTWRDPNVAVVNTDKGRSFVRPRWGRQTWRDVGPLALIDGAGKGVQEKNSYERAPILNQASIYLECEQQTTTIEVYGLQTDGNMKYLDWRYEELQLPAGLEQVPNGEEFALQAMNNAEKAAWALRKAVNMCVQIKQKKGKKEQKIWPGEWGQRVEDAYWLSLEAPYLAFLSVLAGTAKEEDPDKHLETLMEAWTKEIRNKASDYFTEATKENVSDAEAMRRQIQAEQYLRRSLRFIGVKSPSKDEDAAKKGR
>NC_010337.2|WP_012281749.1|593865_594429_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MNDANRGDAIRNKAEDFIQRVKSLTPGERALLKRNAGCRLSESRGALPLFYRLCPRSIPEWEEDIWFLIACLCCLDRSEKEAEERSFARSLLDFLGKDGFEADGANGWQRKVTKLLDASQEELFYRLPQVVKRLVDNRVPIDWAGLLTDLRIWHWKSRIVQKRWAREFFGSKSNGTGEEQENDGGDN
>NC_010337.2|WP_049754013.1|592705_593866_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MLVEIHVLQNHAPANLNRDESGSPKDCMFGGVRRGRISSQCQKRTIRCSPLFQDSIGESRLGMRTRKLPFLVKEELMRLGLSEELAKIGARKASGLGNKDGKERDDEITAQAIFLTQEDVSVIARCLFRHLKDKTVKQAKAIKAQELQKDPELVGWRPVTVDVALFGRMTTSTAFNDVEASVQVGHAISTHRVDSEFDYFTAVDDLMGDGDSGADMIGDTEFNSCCYYKYFNVDMDELKRNLAGPDRLKKLTAEERQDLARDAAHIVKAFIESLVFCSPDGKQNSFAARQLPSAVLVEVKKRKIPVSYANAFVKPVTARGEMDLVQASVNAFLDHVKETEKCFGLTPNRRWLLLMGCESPKMTTDQVSTFPALVEELTAALQQGEE
>NC_010337.2|WP_012281747.1|592010_592703_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MGIPILALRLEGPLQSWGSRSRWDYRDSALEPTKSGIIGLLGCALGWSRNDKRLESLDAALRLTVRIDKPGTPLIDFHTVQGYLLMAEGKQKKSGNDMYTVVSRRVYLQEASFLALLTGEQGALHQCKKALNDPVWPVFLGRKSCPPARPLFDSFYEGDFRDVLEAMRSIPWSSAPAAGPIRLRYVMEDEGGREWRQDVLRINGARMYGRRRVSVGWVDLDRRRDPDVSK
>NC_010337.2|WP_041313172.1|591337_592024_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MYLSKLLLNIRHSQVRKDIARGHEMHRTLLRAFPEVQSGTESARSHYGVLYWLDTSGERDVTLLAQSRLPPTWEQLPSGYLTRPAAVKNIAPLFDSIQQGQVFRFRLRANPTLKRGGTSKEERQSGEPKRNSKRIFLVGQEAQAEWLMRQGEKYGFQTLVDHTGAPSIRIGASQSLLLGKGGKGQVIHVDYYGLLQVTDDERFRTALIEGIGPAKSYGCGMMMLLERR
>NC_010337.2|WP_012281746.1|590402_591335_-|type-I-E-CRISPR-associated-endonuclease-Cas1
MRDLHELPRLTDSISYLYVEHAVVEQEAKAIALWREDGKVQVPCASLSVLMLGPGTKVSHAAMRTLADCGCSVLWVGEGGLRVYGQGMGETRSSSNLLRQVSLWSNPDTRMAVVRRMYELRFREPVSPEMTLRQIRGMEGGRVRQIYARLAKEHGVVWTGRNYDRGNWNSADPVNRALSAANACLYGVCHAAIVSMGYSPAVGFIHTGKQLSFVYDVADIYKTDTTIPVAFTVAGKNDVANIEREVRLACRQQFHDKRLLERVAKDLSMLFSGINLPEVIEGYDGSDDKPGGIWDDQDGIVSGGKNYSDE
>NC_010337.2|WP_012281755.1|605845_606634_-|P-loop-NTPase
MTCEVIIAVMSGKGGTGKSTVTAFLAAGLAKAGLAVAVVDGDVAGSAIPTLFGLKAPLRRQGDRRMPAVTRRGIAVWSAGLLPDEGQSLLADSGARRRDTLGEWIGSAAQGEWDVVLIDMPSGLGEVHAAVVDAFAGLSIQSDGEPDGAGPRKPVTGALLVTSLRELDRRVVRRTAAWLKEKGVPIVGVVENGGEIECPHCENLLPLSDGDEAWAEEGGVIACFPWSAKLIEFARKGRLEEYDHPLVFQMALNIWESSHKEG
>NC_010337.2|WP_049754214.1|606797_607406_-|amino-acid-ABC-transporter-permease
MTGLQWTIELALISIALSFFFGIVICALRISRYPFLRYPAFLYVESLRNLPLILLIFFTYFALPKIGLGLPKFWAAVVAFTIFTSALVAEIIRGGIQSVPKGQWEAARAQGFTYLETMVYIILPQALRKMIPPLISQFITLTKDTSYASIIGLTELTEHGKLIFIEHNNPVQVFFFVACIYFVVNFTLSRLGMYMEKRMAIG
>NC_010337.2|WP_012281757.1|607475_608129_-|amino-acid-ABC-transporter-permease
MEQWNDLLAYGPQFFSGLKVTIEVTLYSLLLSMVIGVAIAILRVSGFKVLNAFGVAYVEFFQNTPLLIQVFFIYFGTPAMGIKLSGFACGTIGLAMYTGAYIGEVFRAGIQAVPKGQMEAARSSGMNYLQAMGYVVLPQAVKIILPPLTNQVVNMVKNSAILSTIVVADLMYETYRIASETFIIFEVFIFAALLYLVITVPLSTVANLLEQRLRRSS
>NC_010337.2|WP_012281204.1|608222_609650_-|group-II-intron-reverse-transcriptase/maturase
MMEGEATMRSRDAQRQPNIPKGNCQREEAVNPQGTGGVPSALPAQEAKQPREETYDLMEKVVERGNMTEAYKRVMANKGAAGIDGMGLESLRPYLKEEWSRIKQELLEGTYRPQPVRRVEIPKPQGGTRKLGIPTVVDRLIQQALNQILMPIFDPDFSTNSYGFRPGKSAHQAVKKAKEYIADGYRWVVDMDLAQFFDRVNHDILMARVARKVKDKRILKLIREYLKAGVMLNGIRVKSEEGTPQGGPLSPLLANIILDDLDKALESRGHRFCRYADDCNVYVRSRRAGQRVMEGMAKFLEGRLKLQVNWEKSAVDRPWNRKFLGFSFTWHKAAKIRLAPQTVKRVKEKIRQFTGRNRSIAMEDRLVTLNQYLKGWMGYFRLIDTPSVLKELDEWLRRRLRMCLLKQWKRPKTRRRNLVALGIPEEWACNISGSRKGYWRLSLTPQMNKALGLAYWREQGLVSLVETYQSHRQPA
>NC_010337.2|WP_148207065.1|610083_610947_-|transporter-substrate-binding-domain-containing-protein
MRRMSMFKKWTKGIALCCTAALLGTLAVGCGGSAPTGGEKKAAENQTQTSGDYIQTIKNRGYLIAGVKNDVPLFGQLKSGADKPEGFEVDIMKELAKKLFGDESKVKLEKVESQTRIPMLQNGQIDIVAGTTTITEERKKQIDFSDVYFKAGQSLLVKKGSPIKSVTDLKGKTVSTVRGSTSAKNIREKAPDAKVDEYATYTEAFQALKLGRSDAMTTDNSILMGFANEDPNFELVGGLFTEEPYGFGFQKGHPEWVNYVNDFLKELKANGKYDELYKKWFKEDPPK
>NC_010337.2|WP_041313177.1|611043_611778_-|amino-acid-ABC-transporter-ATP-binding-protein
MIRFEKVNKWFGKLHVLRDIDLHIREGEVVVVIGPSGSGKSTLLRCINKLETVTEGRLTVDGFRIDDPKTNINLLRQEIGMVFQHFNLYPHKTVLENITLAPIKVRKVAKEEAEKTAMFYLNKVGIPEKAQAYPSQLSGGQQQRVAIARGLAMKPKIMLFDEPTSALDPEMINEVLDVMKTLAKEGMTMVVVTHEMGFAREVADRVIFMDNGAIVEEGTPEHFFINPREDRTKLFLSKILTSAR
>NC_010337.2|WP_012281760.1|611836_612946_-|HD-GYP-domain-containing-protein
MYSARTGKVSEQYAIGDVLAADVFTVDGRLLIPKGTVLTDGIYRQILKWEEIGILTGQKPKTVSTVEMQYESLKKVGQEQILFQQSIETVRDVFLDMREGHGFNEGAIRSTTSDIVSTIARDEKIGLRLSRLWDSDDYTFHHSVDVCLLSTMIGMSLGLSKTELESLAIGAILHDIGKIYIPDAILNKRGKLTDEEFALIRTHPEAGMKVFQESGIRLPEEQMACILQHQEWCNGKGYPNGLRYAHIHLFARIVAVADVYSALTTNRSYRVRLDHINAVSIISSHARDHLDKHIVFVFIDRLRDLMLNTRVRLSTGEEGYVVQFYEESPLQPTVLVTETADGRKLVSPYLVHLKEKTDIFIQQVLYGKI
>NC_010337.2|WP_012281761.1|613376_613817_+|CBS-domain-containing-protein
MNIAFFLIPKKDVIHLPINATMRQAAEKMEYHRYTAVPLIDSQGRYVGTLTEGDLLWKWKNTPGLSFDNMHKVSLNDVPRRMNIKPVHIYAEMEELITLASEQNFVPVLDDRGVFIGIVRRREIIEYCAGLLQAGRPAVRVAANQG
>NC_010337.2|WP_012281762.1|614017_615157_-|sporulation-protein-YhbH
MAGDFSISREDWSLHRKGFIDQTRHQEKVREAIKKNLPQIISEEALILNNGQKTVKVPIRSLEEYRIRYDYNKQKHIGQGNGDSKVGDVLGRELQPAPGQGNGGAGSEPGLDYFEAEVDIDELEDILFADLHLPNMEEKAAPELETESYRFNDIRKKGLQGNIDRKRTLIEAFKRNALKGTPGFFPVLPEDLRYKTWEIHHERHSNAVVLAMMDTSGSMGNFEKYIARTFFFWMTRFLRSKYHAVQIVFVAHHTEAKEVTEEEFFTKGESGGTRCSSAYQLANEIIDKRFPPQDYNIYAFHFSDGDNLSTDNEQCVRLVNDLLGKCNQFGYGEIVRSHFSSTLMNAFRKIQSLKFSTVTIRDKSEVYGALKTFFKPVEM
>NC_010337.2|WP_012281763.1|615169_617065_-|PrkA-family-serine-protein-kinase
MEFLDKLENYRQRERELAWEGTFRDYLHLVKERPFITQLAHSRIYNMIVSEGVEEINGIRRYKFFSHELFGMDKTLETLVEEYFHSAARRTEVRKRILLLMGPVSGGKSTIVMMLKRGLERFSRTELGALYAIKGCPMHEEPLHLIPKELREDFQREYNVYIEGSLCPHCRMRLETEWKGRIEDVPVERIFFSEENRVGVGTFSPSDPKSQDIADLTGSIDFSTISEYGSESDPRAYRFDGELNKANRGMMEFQEMLKADEKFLWNLLSLSQEGNFKAGRFALISADELICAHTNESEYKAFVSNKKNEALISRMIVVRVPYNLKVSDEVRIYEKLISQSDLRHIHIAPHALRAAAMFSVLSRLKESKKQGMDLVKKMRLYDGEDVEGFKQKDLVELQNEALDEGMSGADPRYVINRLSSALIRKDTVCINALDVLRAIKDGLDQHPSISKEERDRLLNYIAIARKEFDDIAKKEVQKAFVYAYEESARTMLNNYLDNVESYCNGTKLQDPITDEEMDPDEKLMRSIEEQIGISENAKKAFREEILIRLSTYARKGKSFDYTSHERLKEAIEKKLFADLKDVVKITTSSRTPNAEQLKRMNEVTARLIEDHGYCHVCANELLRYTGSLLNR

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Crispr_ID: NC_010337_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010337_4

688615-688709

Orphan

Consensus_repeat	Method
TTGTCCCCCGATGAGGAAGGGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010337_4

>merge|NC_010337|4|688615-688709|CRISPRCasFinder
TTGTCCCCCGATGAGGAAGGGCAGAACCGGCAAAGCCGCGCAGCGGCGTGGTCAGTCGACCGATTCAGGTCATTGTCCTCCGATGAGGAAGGGCA

>NC_010337|4|4|688615-688709|CRISPRCasFinder
TTGTCCCCCGATGAGGAAGGGCA	GAACCGGCAAAGCCGCGCAGCGGCGTGGTCAGTCGACCGATTCAGGTCA
TTGTCCTCCGATGAGGAAGGGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_010337.2\|WP_012281820.1\|683493_683796_+\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012281822.1\|685529_687080_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_010337.2\|WP_012281818.1\|680738_683231_-\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_010337.2\|WP_012281835.1\|699411_700722_-\|globin-coupled-sensor-protein	unknown	unknown	gnl\|CDD\|214599
NC_010337.2\|WP_012281832.1\|691636_692143_+\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|368753
NC_010337.2\|WP_012281829.1\|690484_690796_-\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012281834.1\|695245_699307_+\|dynamin-family-protein	unknown	unknown	gnl\|CDD\|206739
NC_010337.2\|WP_012281837.1\|701756_703034_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|238487
NC_010337.2\|WP_012281821.1\|684129_685530_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|236901
NC_010337.2\|WP_187147801.1\|692436_695061_+\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|306825
NC_010337.2\|WP_012281813.1\|676784_677063_+\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012281816.1\|680252_680582_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378946
NC_010337.2\|WP_012281824.1\|688161_688479_+\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012281830.1\|691041_691401_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_010337.2\|WP_012281823.1\|687256_688105_+\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|223425
NC_010337.2\|WP_041313196.1\|677136_679974_-\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_010337.2\|WP_012281828.1\|689356_690349_+\|arsenic-resistance-protein	unknown	unknown	gnl\|CDD\|223869
NC_010337.2\|WP_012281836.1\|701071_701701_+\|redox-sensing-transcriptional-repressor-Rex	unknown	unknown	gnl\|CDD\|235486
NC_010337.2\|WP_012281826.1\|688890_689133_-\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012281812.1\|676433_676736_+\|divergent-PAP2-family-protein	unknown	unknown	gnl\|CDD\|376897

Protein	Function_ID	Function_description	E-value
NC_010337.2\|WP_012281832.1\|691636_692143_+\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	3.64717e-12
NC_010337.2\|WP_012281822.1\|685529_687080_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	4.23845e-170
NC_010337.2\|WP_012281818.1\|680738_683231_-\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_010337.2\|WP_012281835.1\|699411_700722_-\|globin-coupled-sensor-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	3.92943e-50
NC_010337.2\|WP_012281837.1\|701756_703034_-\|PDZ-domain-containing-protein	gnl\|CDD\|238487	cd00987, PDZ_serine_protease, PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this subfamily of protease-associated PDZ domains a C-terminal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in Eumetazoan signaling proteins.	3.88791e-07
NC_010337.2\|WP_012281834.1\|695245_699307_+\|dynamin-family-protein	gnl\|CDD\|206739	cd09912, DLP_2, Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins. The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.	7.46506e-33
NC_010337.2\|WP_012281821.1\|684129_685530_+\|sensor-histidine-kinase	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	3.57062e-51
NC_010337.2\|WP_012281828.1\|689356_690349_+\|arsenic-resistance-protein	gnl\|CDD\|223869	COG0798, ACR3, Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism].	1.71924e-28
NC_010337.2\|WP_012281816.1\|680252_680582_+\|hypothetical-protein	gnl\|CDD\|378946	pfam12788, YmaF, YmaF family. This family of proteins contain 6 HXH motifs and is named after the B. subtilis YmaF protein. It seems likely that these are involved in metal binding. The function of this protein is unknown.	4.485e-17
NC_010337.2\|WP_012281830.1\|691041_691401_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.95124e-13
NC_010337.2\|WP_012281812.1\|676433_676736_+\|divergent-PAP2-family-protein	gnl\|CDD\|376897	pfam02681, DUF212, Divergent PAP2 family. This family is related to the pfam01569 family (personal obs: C Yeats).	8.89687e-07
NC_010337.2\|WP_041313196.1\|677136_679974_-\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_010337.2\|WP_012281836.1\|701071_701701_+\|redox-sensing-transcriptional-repressor-Rex	gnl\|CDD\|235486	PRK05472, PRK05472, redox-sensing transcriptional repressor Rex; Provisional.	7.00443e-110
NC_010337.2\|WP_187147801.1\|692436_695061_+\|S-layer-homology-domain-containing-protein	gnl\|CDD\|306825	pfam00395, SLH, S-layer homology domain.	0.0001576
NC_010337.2\|WP_012281823.1\|687256_688105_+\|4Fe-4S-binding-protein	gnl\|CDD\|223425	COG0348, NapH, Polyferredoxin [Energy production and conversion].	2.31308e-23

>NC_010337.2|WP_012281824.1|688161_688479_+|hypothetical-protein
MRIKPLHYGLLVLALFWGVIGGAMASNLWVTKQSLPPVGTVTSTEEIKGWMTLEQIGETLSLPTPEVIRRLGLPPESDPNKKLKDLAAEQGKTPDQLKEGLLDHK
>NC_010337.2|WP_012281823.1|687256_688105_+|4Fe-4S-binding-protein
MTRKSILHPSRRVTLVRWLSLLFFVGLTSYIGLRHQIVGGGPQGAAPLDTFCIFGGIETLWSYATTGKFLAKTNMANLVLLAAGMLLLLVTGAGFCGWICPLGAIQEWLGGLGKKLFGKTFTVPPSVDRPLRALRYLFLALILYMTIADNKLWFEPYDPFKVLFHFDFETTTSIVVLALFVAFSLPIERFWCRYLCPLSAVYSLVSPLSIFKLKRQPHACIGCGVCTLNCPMGIDVQHCGTIPDGRCIKCLQCMESCPKPDALVLEAGKSRPATSIPPSLSR
>NC_010337.2|WP_012281822.1|685529_687080_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MERPLRLLVADDEEAMRLFLSAALERAGHRVDAVEDGQSALEKIVAAERSKAPYALALIDLQMPRLPGMDLLSHIRREWPRLPVIILTAHGSIPTAVEAMKLGAADFLVKPLPSPGHLRAAVSRVLAQSALNAAAGHNDADRDAVRSDTDPVGIAMTPLGPPTAPAASPSGKVSAQRESGRLSTPAGGVEALRRPNPELAVNDLIACDPATCAVLEQARLVAETDTTVLLLGESGVGKEVFAGVIHRLSKRSAGPFVAVNCAALPTSLIESELFGHERGAFTGAHTMKIGRFEQATGGTLFLDEIGELEATVQAKLLRVLQEKRFERIGGTRSIAADCRIIAATNRDLKAAVQERQFRSDLYYRLAVFPIEIPPLCRRPADILPLATHFLTRFAGKNGRDLPQLTEAALAALQEHPWPGNVRELANAIERALILCAGGPIEPRHLGLAHREKARADQGVKALADSTDDGILKQQERDTILRVLAANGNNRQKTAQQLGISVRTLRNKLKEYRIQTD
>NC_010337.2|WP_012281821.1|684129_685530_+|sensor-histidine-kinase
MTASLPLPVRLLLSLLAATAAILLAASYYNYQRSMEVKRVLLQNKAAGIAQTIEALARKSPSRTPEELQSLIAAWPDDPDLFDLTVFDRNGMIIAHRDPARLGKEDVASLFLVRQVLAEQQMSFRYLKGHTPSASSTGAASGIPESPNHTPPASPLFEAFLPLHLGGFDGEGPRMAGDYQPRFKVLRVQLRESAAGDVSRAALWQLFLIGLVLLGTLTVTAYLVQTLRRYFTLEAQAREQARMASLGQVATWVAHEVRNPLGAIKGLLQLIQETIEERDPDGQSRRYCETAVRESERLERFVGDLLAYSRLPQPTITEWPLANLVQEITALLEPELARQDAAIVTQIEPPGLIVRADREQMHRLLLNLIQNALAAMPSGGDIHLRALSSPTEEGLSIIVEDEGIGLPPGAEHRLFEPFFTTREKGSGLGLAICRDIANRHGGTIRAEGAPGGGARFIVNLPEKGEL
>NC_010337.2|WP_012281820.1|683493_683796_+|hypothetical-protein
MSKNKPNSKASSQKETAATATAPATTTVKKYGPDNPNEELLKSPAVKLVAIAFGTAVSYIVGRMVQGGGPQEVPLGLYAAGFFLSTSLFLFVRSLLKKKK
>NC_010337.2|WP_012281818.1|680738_683231_-|excinuclease-ABC-subunit-UvrB
MEQRLFQLKSEFVPKGDQPQAIARLVEGIEKGMRYQTLLGATGTGKTFTMASVIEKVQRPTLVLAHNKTLAAQLCAEFKEFFPDNAVEYFVSYYDYYQPEAYVPQSDTYIEKDASINDEIDKLRHAATAALIERRDVIIVASVSCIYGLGSPEEYLDQMISLRKGQIYDRDAVLRRLVDIQYSRNNINFTRGTFRVRGDVVEVFPASYSDRAVRLEFFGDELERISEIDTLTGEVYGERYHISIFPNTHYVTNWDKLELSIANIEAELEERLAWFKEQGKLVEAQRLAQRTRYDIEMLREMGFCTGIENYSRHLTFRPPGEPPYTLMHFFPKDFLLMVDESHVTIPQVGAMYQGDRSRKMTLIEHGFRLPSAADNRPLKFHEFEQMLNQVVFVSATPADYELQRSEQVVEQIIRPTGLIDPVIDVRPVKGQIDDLLGEIRERIKKDQRVLVTTLTKKMAEDLTAYLRNVGVRVRWMHSDVDAIERMQIIRDLRLGEFDVLVGINLLREGLDLPEVGLVAILDADKEGFLRSDRSLIQTIGRAARNVEGTVIMYGDRLTRSMQKAIDETNRRRAIQIAYNEQQGITPQTVKKAVRNVIEMTISGGDRKEAAGAATTGGGVLARAAAFLKKRTGKKGAESAVDAWTTQAAAPGEGAYGTGYAGDDGARVLREGGHGGGAGTYEVSSDRSADRVAEGLPPEEGFEAAAPERVASSEAMAPEQLAALIADLEGEMRQAAKELDFERAALLRDVIIELKGAAPAKSKTGGGMASGAATGAAKAARGGRKPSANDGNGTARAKGRGRGKSQAPQDPGLDFFPPSAGPSRPRGRKKG
>NC_010337.2|WP_012281816.1|680252_680582_+|hypothetical-protein
MRCKPKPPYDDGDCGFHTHDYHFESCLSEGHRHMLSGQTEPSVNKRDHAHRYAGVTSFNDNHVHYYCGCTGPAIYRPGCGHYHCMEGTTTCDDGHVHRYEDKTCNRSKL
>NC_010337.2|WP_041313196.1|677136_679974_-|excinuclease-ABC-subunit-UvrA
MMDQIRVRGARAHNLKNIDVDIPRDRLVVVTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDYIEGLSPAISIDQKTTSKNPRSTVGTVTEIYDYLRLLFARVGRPHCPKCGRPIRQQTVEQMVDQILAHPEGTRLQILAPLVRGKKGEHVKVIEDIRKNGYVRMRVNGQVMDATEEVKLEKNKKHTIEIVVDRIILKADIATRLADSLETALNLSEGLAVVDFMGEKEFIFSQNFACADCGISVGEIEPRIFSFNAPYGACPHCTGLGVQMEVDPDLVVPDPTKSIDEGAIVPWARMNSAYIPQMLKALAELHGFSTETPFKDLPPEIQKLILYGGSKEKIRLQFTNYDGERRSFETTYEGVVTNLERRYKETQSDWSREEIEEYMTQKPCPACKGARLKPESLAVLVGGKNIHEVTEMSVAAALRFFTDLDLSEREMIIARQIVKEIRERLGFLVNVGLTYLTLARPAGSLSGGEAQRIRLATQIGSGLMGVLYILDEPSIGLHQRDNERLLATLQRLRDLGNTLIVVEHDEDTMLAADHIIDIGPGAGAHGGQIIAEGPLSVIMEEPRSLTGQYLSGRKFIPVPEKRREPNGKWIEVLGACENNLKEIDVSFPLGVFICVTGVSGSGKSTLVNEILHKALASQLNGARSKPGAHRAIRGLEHLDKVIDIDQSPIGRTPRSNPATYTGVFDAIRDLFSQTAESKMRGYRPGRFSFNVRGGRCEACKGDGIIKIEMHFLPDVYVPCEVCKGKRYNRETLEVRYKGCSIADVLDMTVDESLAFFRNIPKVARKLQTLQDVGLGYIRLGQPATTLSGGEAQRVKLATELSRRSNGKTFYILDEPTTGLHIADIDRLLGVLQRLVDAGDTVLVIEHNLDVIKTADYIVDLGPEGGDGGGTVVAAGTPEEITQVAASHTGRFLKKVLQRKPGSAL
>NC_010337.2|WP_012281813.1|676784_677063_+|hypothetical-protein
MDRLTEIFLALRSAFTEPLEEKIRFESLHVELTSAEFFYLAITAYFIGGMVIGYLWAKSKYAPSRQTSSTDGAKPSYLDSGENPSDGNRIDE
>NC_010337.2|WP_012281812.1|676433_676736_+|divergent-PAP2-family-protein
MQAVPIRATATAAIGAVVIFDAMAIGRSAGEHARTSNWLLVFSQIRRGKKVPWQERPGHSPPEVSPAPSWGCSSLGPSADDGQPALFVKEISTKFRATAL
>NC_010337.2|WP_012281826.1|688890_689133_-|hypothetical-protein
MILRPVCYRTVSPHCGKPAQMRLNCGRVLRGRIQRVTPNGVWFYSSNPGLFFYPFFAISVLALTLPFWAGFGYGYGRGYR
>NC_010337.2|WP_012281828.1|689356_690349_+|arsenic-resistance-protein
MGKTALFWPSKNPVLSIPITLALGFTAGLFVDTSSLGNFILICTFLMIYPTMIGVKLKEAFDFSHAKVVGISLIINFLLIPLLAWGLGTTFLSGDPSMMAGLAIAGLLPTSGMTISWTMMFKGNVPAAIKMTALSLIIGSILAPFYLLIMVGKYVPIDLMKTFTTIAVIVFLPLVLGHVTFLQLKKKYSQEHFQKVIKPYLPAVSFWAMLAIIFASISMKSKMVLARPDLLGGILLALAVFYLINFTLSTVIARLFLNRADGVALIYGTVMRNLSIALGLAITAFGPQAALVVTLAFILQVQAAAWYGKMADRFGFFGKTPSDSLAVKQA
>NC_010337.2|WP_012281829.1|690484_690796_-|hypothetical-protein
MAVTLSLFQRYTIARQLMKRLAERYGHDDNRVLCQSVKVDKLVVALYRSKITKKVILYEKNSKTGAELPQKAVPNQQRAKRWKRQIRCKQACEEKQTLLVHCQ
>NC_010337.2|WP_012281830.1|691041_691401_+|helix-turn-helix-transcriptional-regulator
MDSIGNRIKHLRKQRGLTQPQLAKLLNVSPQVISNWERGYTPTIAPESIDKLASILETTSDFLLGRSTASISSSLEALEKSWPEGIKVLRRANEKLTPEKKRVILELIDTYVRTEGNHD
>NC_010337.2|WP_012281832.1|691636_692143_+|ImmA/IrrE-family-metallo-endopeptidase
MIARHFRGSSALPLGFDPTCHALSQQARLFWDKRVDDGITFYHSHSGSYTVILNPSLPRGRLHWTMAHELGHILLGHFTDYNTNRLTAHEEKILDREADEFTKEFLMPAATVIGAVRRPLTVAKIGRVKNLFQVSWEATGNRLIELALIHPLELHRLYHHHQKQLHRE
>NC_010337.2|WP_187147801.1|692436_695061_+|S-layer-homology-domain-containing-protein
MRRRLISACVALSIVLSPTAGLAAVRQFGDVSTVMPEYRPIMKLSAQGTIKGRGDGNFGPSDPVKQLEALVMVQRFFGMEATATAAASRLTPDMEKKFGGNVPAWGKGYLVTAVNQNLLDANEYFPWHQGATRAWVARLLVRLLNKEQEAQSRMNAPLTFADATLIPASLRGHIAVATDLGLIRGRENGCFDPNSIVTRGEMAIFLDRAERKMDRLPPGIDEATFISGRDAILSVLDEENRLSSLTLDANARIFGTERAVALSDLNPQDKIRYIQDGDKVVYLEVVQGSGQKANVLRGEVIASLPEQGLLTLKDDAGKPFTYSLATSVSVIDLAGQMLSTSHVGPGSKAQLRLNNEGKIAEILLESVGQQGLYGTIVDINLTAKLLILSDGANHYSSYYLADNTTVEYNGKRFASLEDLAKGDLVSVEVDGSYVVNKIILQKPKSTVTVKGTVSLISRDSRLVTIKGDDGQLYAFELPETTALQFSDGTSAAIENLYLQDTVTLQLENGTVKKLVIVRAGNTKGLTGKIASIDANRRLLIVKDARDRLQSYEINDPVILDIEGNTKPTISNLGIDTSIEFELNADNKITYIKSKNTIEGVVTRVDADRHLITLRDAAGTEKIYTVETNAECQIFRRSGEDLDDIDVDDRVKVRVSGDKINRIQVHTQLTGEIIDKTSERIYIKDIDNNERSYTVNSTLKLIVPNIIKPSLSDVTIRQWAVVSYWGDEPYQIAVQTPVAGEVTGVDTGRDKLVIRQYDGSSRTLEKASPFKVDKGGTTSYGLSAISIGDRIQAFTDEQNRIMRAFVASKVSGKIDGINRTTKDIYIGTTVGYHIDSNTIITLNGVRKNFDDIQQKQSATIYYTGGYNAIEVNLSN
>NC_010337.2|WP_012281834.1|695245_699307_+|dynamin-family-protein
MKLTTNPLPASAIIPMLIERLQTLADRFRQSRDEHAAYAAETLIGKLRRRQLRIAFCGHVSGGKSALINALIGDDILPTSPIPSSANIVTVRSGPASARARLKSGETVELDLFANLSGVQEHCLDGTDTHSVDIAIPIDLFGCAVDLVDTPGVDSAEAARRLAEDPAIVAADVIFYVMDYNHVQSEINFSFTKRLKERGKPVFLIVNQIDKHCDFELDFDYFRRSSAASFAAWDIQPEGIFFTSLSDPSHPENELPRLKARLRDLFRHEEELLVASVLPATRQLIDDHCRRLAEADREERQRLQALLDAAEDLEEALQSYGQVSRRIDELQRAPQRLKEELDREIRRVVENARITPHTTSELARRYLESRSSGFKVGFLFSSEKTKKEIATRLAAVYADFRQHVSTQLEWHLRDVLARVAERHGVTDGEYIQRANSLTVHWGADLLARLVREGAVVGNEYVHNYTRDIAAEVKSLYRREALALAEEAVQLAKRAAARQIEQLTRQLEPLQPLVDAIKTLDKMEQAERKSRNELLAALHRGLPEVVPMESLLSPPPETADSAAGGTGGTAAAVSGTAPDPLAGLGQALREQSAPERAASGRSDFDLAADLLAAPALNAATGLSDGATPPILQHTAQRLRRCAAAVAPLPGFAHIAEELASRAERLEKNIFTVALFGAFSAGKSSVANALLGRPVLPVSPNPTTAAINKILPPNEENPHGTVRVRLKTAADIESDVLHSLSACDVAASNMAEALRRLHEISPGDIHPTAKPHYSFLRAVARGIGAVESRLGEEQIIDLDAFQDYVASEEKACFVEWIELYYRCPLTARGVMLVDTPGADSINARHTGVAFDYIKKADAILFVTYFNSAFSHADRDFLFQLGRVKDSFGLDKMFFLINAADLARSAGELAEVQRHVAERITACGISKPRLYTVSSQTALLARLGELGLLTASQKKTYRQRTNSLAAVRKAGTAREGIGGIGGGIGAGIEGGIEGGIEGSIEGSIEGSIEGSIEGSIADSAGLLPWSAAFSLSGYDRFEADFYGFTLHELTQIAVSAAEGDIQRCLAGLDDMIEAARLDASARRRQRVACETSRLEAERAVSAVSVDADGDLLDKEADELIYYVNQRIFYRFGDLYDRYFNPSVLQDSRGNITKQSMQHCLEELLQTLEKELAQEIRATSLRLEQFVHKRAGQYRNKLAQSIGAIDSRCALPAYEPVALPALEIPEQLSLSRSEALRVLPNGFGNPKDFFEGSGRNRLRSQLEESLRTPVQNYLSDASVVVKAIYAPLLAQRLEEARHRALQAVADHYAGLLAALDADFDLAAAEGIRADLAMHAGLGDESRFRQPATATAATSAWR
>NC_010337.2|WP_012281835.1|699411_700722_-|globin-coupled-sensor-protein
MFWRKSADESEPRPYRGPKPTISLQDPSFQLSVRFIKLTPEQLELLQEIRPILEQNVDAAVEAFYGHLGAMAEMREFIDRTTTVDRLKKTMRNYILSLAPMKIDDNYVFERYKIGKAHDRIALPPYWFTSAYQLHYNFLIPKIMDAYKDKERAKQAVTALLTITNLDQQLAMSSYIESYTSGLSKKEELERILNDLTSLQQQVNDASQSLAATAEETAASAAHMSTSVERITRNVTEAAKHSAEVVTLAKGGEGQLKEAVQAIRELSQLMLDMKQKIAALDVSSEKISSIAEVIQGIASQTNLLALNAAIESARAGEQGRGFNVVAQEVKKLAGSSEQSVKEIAEMIQQSRHHTADVSGSMEQNAKSMERVNELVDKVVQGFSQIIQSIALNQEQMRQISDEVVTLSTTAHEIENASESVAHSAEELAMMAQEIKQ
>NC_010337.2|WP_012281836.1|701071_701701_+|redox-sensing-transcriptional-repressor-Rex
MKMLKIPEPTVVRLSLYSRFLNQASSKGIDIISSDEIGAAVGIPSAQVRKDLSYFGEFGIRGVGYRVRELCSQVDKLLCVNQTWPVIIIGAGHLGLAMSGYRGLQDRGFDVIALFDANPAKQGELPNGLSVLPMERLAETVREKDIRIGIITVPADAAQQVAEALIAAGITAIINFAPTVLNVPPEVKVRNIDLTVNLEVLSFNLGMRG
>NC_010337.2|WP_012281837.1|701756_703034_-|PDZ-domain-containing-protein
MAPWDLIRLVLEAMEVLLLQPQEYPSFWVFLFIIALLYRRQSRLKAELFQLEREGWWRPVLYSAVYGVIAGFFGSLLMLFFGITIVAAGFIYLLPVALLLALINVRYMCYAYAGGLISLAALFMGWREVSAAQIMGLVAILHLVEALLIYLSGHLSRLPVFIAHRKGMTVGAFNLQSFWPIPLLVLTLLPVPVDSGLPWQEIATPDWWPLIAQPPFDYDAAKEIAVLFPLPIVALLGYGDLAVTRLPAAHARRSAAHLALYSAILLALAVVASNVPALAALPALFGPLGHEALILWSRRREMKGVPIFTPSLRGLRVLDIGAGSPADRLGLRAGDVVGRINGMTVLSKRDMAIALSWSPSDVDVEYLPGGQGTVWKRGSVVKGWKEPLGLIAAPDPEEPPLVKLETGGILARPLAWLLGLWRGRR

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Crispr_ID: NC_010337_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010337_5

692143-692231

Orphan

Consensus_repeat	Method
AGCCAGGCCCTTGCCTGCATGGAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010337_5

>merge|NC_010337|5|692143-692231|CRISPRCasFinder
AGCCAGGCCCTTGCCTGCATGGAAGGCAGCGATGTCAAAGCGCATCAGCTACGGTACTGGCTCAAGCCAGGCCCTTGCCTGCATGGAAG

>NC_010337|5|5|692143-692231|CRISPRCasFinder
AGCCAGGCCCTTGCCTGCATGGAAG	GCAGCGATGTCAAAGCGCATCAGCTACGGTACTGGCTCA
AGCCAGGCCCTTGCCTGCATGGAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_010337.2\|WP_012281820.1\|683493_683796_+\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012281822.1\|685529_687080_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_010337.2\|WP_041313211.1\|707322_708267_-\|transketolase-family-protein	unknown	unknown	gnl\|CDD\|226467
NC_010337.2\|WP_012281835.1\|699411_700722_-\|globin-coupled-sensor-protein	unknown	unknown	gnl\|CDD\|214599
NC_010337.2\|WP_012281839.1\|704423_705599_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NC_010337.2\|WP_012281837.1\|701756_703034_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|238487
NC_010337.2\|WP_012281829.1\|690484_690796_-\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012281834.1\|695245_699307_+\|dynamin-family-protein	unknown	unknown	gnl\|CDD\|206739
NC_010337.2\|WP_012281840.1\|705640_706522_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225088
NC_010337.2\|WP_012281841.1\|706518_707217_-\|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl\|CDD\|225438
NC_010337.2\|WP_012281821.1\|684129_685530_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|236901
NC_010337.2\|WP_187147801.1\|692436_695061_+\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|306825
NC_010337.2\|WP_012281838.1\|703177_704350_-\|S41-family-peptidase	unknown	unknown	gnl\|CDD\|223864
NC_010337.2\|WP_012281824.1\|688161_688479_+\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012281830.1\|691041_691401_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_010337.2\|WP_012281823.1\|687256_688105_+\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|223425
NC_010337.2\|WP_012281828.1\|689356_690349_+\|arsenic-resistance-protein	unknown	unknown	gnl\|CDD\|223869
NC_010337.2\|WP_012281825.1\|688524_688806_+\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012281836.1\|701071_701701_+\|redox-sensing-transcriptional-repressor-Rex	unknown	unknown	gnl\|CDD\|235486
NC_010337.2\|WP_012281826.1\|688890_689133_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_010337.2\|WP_012281822.1\|685529_687080_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	4.23845e-170
NC_010337.2\|WP_041313211.1\|707322_708267_-\|transketolase-family-protein	gnl\|CDD\|226467	COG3958, COG3958, Transketolase, C-terminal subunit [Carbohydrate transport and metabolism].	4.28317e-152
NC_010337.2\|WP_012281835.1\|699411_700722_-\|globin-coupled-sensor-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	3.92943e-50
NC_010337.2\|WP_012281837.1\|701756_703034_-\|PDZ-domain-containing-protein	gnl\|CDD\|238487	cd00987, PDZ_serine_protease, PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this subfamily of protease-associated PDZ domains a C-terminal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in Eumetazoan signaling proteins.	3.88791e-07
NC_010337.2\|WP_012281836.1\|701071_701701_+\|redox-sensing-transcriptional-repressor-Rex	gnl\|CDD\|235486	PRK05472, PRK05472, redox-sensing transcriptional repressor Rex; Provisional.	7.00443e-110
NC_010337.2\|WP_012281834.1\|695245_699307_+\|dynamin-family-protein	gnl\|CDD\|206739	cd09912, DLP_2, Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins. The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.	7.46506e-33
NC_010337.2\|WP_012281840.1\|705640_706522_-\|ABC-transporter-permease	gnl\|CDD\|225088	COG2177, FtsX, Cell division protein [Cell division and chromosome partitioning].	5.38402e-79
NC_010337.2\|WP_012281841.1\|706518_707217_-\|cell-division-ATP-binding-protein-FtsE	gnl\|CDD\|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	2.82738e-129
NC_010337.2\|WP_012281821.1\|684129_685530_+\|sensor-histidine-kinase	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	3.57062e-51
NC_010337.2\|WP_012281828.1\|689356_690349_+\|arsenic-resistance-protein	gnl\|CDD\|223869	COG0798, ACR3, Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism].	1.71924e-28
NC_010337.2\|WP_012281839.1\|704423_705599_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.97958e-51
NC_010337.2\|WP_012281830.1\|691041_691401_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.95124e-13
NC_010337.2\|WP_012281823.1\|687256_688105_+\|4Fe-4S-binding-protein	gnl\|CDD\|223425	COG0348, NapH, Polyferredoxin [Energy production and conversion].	2.31308e-23
NC_010337.2\|WP_012281838.1\|703177_704350_-\|S41-family-peptidase	gnl\|CDD\|223864	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane].	5.56385e-121
NC_010337.2\|WP_187147801.1\|692436_695061_+\|S-layer-homology-domain-containing-protein	gnl\|CDD\|306825	pfam00395, SLH, S-layer homology domain.	0.0001576

>NC_010337.2|WP_012281830.1|691041_691401_+|helix-turn-helix-transcriptional-regulator
MDSIGNRIKHLRKQRGLTQPQLAKLLNVSPQVISNWERGYTPTIAPESIDKLASILETTSDFLLGRSTASISSSLEALEKSWPEGIKVLRRANEKLTPEKKRVILELIDTYVRTEGNHD
>NC_010337.2|WP_012281829.1|690484_690796_-|hypothetical-protein
MAVTLSLFQRYTIARQLMKRLAERYGHDDNRVLCQSVKVDKLVVALYRSKITKKVILYEKNSKTGAELPQKAVPNQQRAKRWKRQIRCKQACEEKQTLLVHCQ
>NC_010337.2|WP_012281828.1|689356_690349_+|arsenic-resistance-protein
MGKTALFWPSKNPVLSIPITLALGFTAGLFVDTSSLGNFILICTFLMIYPTMIGVKLKEAFDFSHAKVVGISLIINFLLIPLLAWGLGTTFLSGDPSMMAGLAIAGLLPTSGMTISWTMMFKGNVPAAIKMTALSLIIGSILAPFYLLIMVGKYVPIDLMKTFTTIAVIVFLPLVLGHVTFLQLKKKYSQEHFQKVIKPYLPAVSFWAMLAIIFASISMKSKMVLARPDLLGGILLALAVFYLINFTLSTVIARLFLNRADGVALIYGTVMRNLSIALGLAITAFGPQAALVVTLAFILQVQAAAWYGKMADRFGFFGKTPSDSLAVKQA
>NC_010337.2|WP_012281826.1|688890_689133_-|hypothetical-protein
MILRPVCYRTVSPHCGKPAQMRLNCGRVLRGRIQRVTPNGVWFYSSNPGLFFYPFFAISVLALTLPFWAGFGYGYGRGYR
>NC_010337.2|WP_012281825.1|688524_688806_+|hypothetical-protein
MTDRDVTEGFPSPSHPLRFVQPGREGASQALSPDEEGQNRQSRAAAWSVDRFRSLSSDEEGQITRESGSEIQSWGDFALQRELHRSSDDDLLT
>NC_010337.2|WP_012281824.1|688161_688479_+|hypothetical-protein
MRIKPLHYGLLVLALFWGVIGGAMASNLWVTKQSLPPVGTVTSTEEIKGWMTLEQIGETLSLPTPEVIRRLGLPPESDPNKKLKDLAAEQGKTPDQLKEGLLDHK
>NC_010337.2|WP_012281823.1|687256_688105_+|4Fe-4S-binding-protein
MTRKSILHPSRRVTLVRWLSLLFFVGLTSYIGLRHQIVGGGPQGAAPLDTFCIFGGIETLWSYATTGKFLAKTNMANLVLLAAGMLLLLVTGAGFCGWICPLGAIQEWLGGLGKKLFGKTFTVPPSVDRPLRALRYLFLALILYMTIADNKLWFEPYDPFKVLFHFDFETTTSIVVLALFVAFSLPIERFWCRYLCPLSAVYSLVSPLSIFKLKRQPHACIGCGVCTLNCPMGIDVQHCGTIPDGRCIKCLQCMESCPKPDALVLEAGKSRPATSIPPSLSR
>NC_010337.2|WP_012281822.1|685529_687080_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MERPLRLLVADDEEAMRLFLSAALERAGHRVDAVEDGQSALEKIVAAERSKAPYALALIDLQMPRLPGMDLLSHIRREWPRLPVIILTAHGSIPTAVEAMKLGAADFLVKPLPSPGHLRAAVSRVLAQSALNAAAGHNDADRDAVRSDTDPVGIAMTPLGPPTAPAASPSGKVSAQRESGRLSTPAGGVEALRRPNPELAVNDLIACDPATCAVLEQARLVAETDTTVLLLGESGVGKEVFAGVIHRLSKRSAGPFVAVNCAALPTSLIESELFGHERGAFTGAHTMKIGRFEQATGGTLFLDEIGELEATVQAKLLRVLQEKRFERIGGTRSIAADCRIIAATNRDLKAAVQERQFRSDLYYRLAVFPIEIPPLCRRPADILPLATHFLTRFAGKNGRDLPQLTEAALAALQEHPWPGNVRELANAIERALILCAGGPIEPRHLGLAHREKARADQGVKALADSTDDGILKQQERDTILRVLAANGNNRQKTAQQLGISVRTLRNKLKEYRIQTD
>NC_010337.2|WP_012281821.1|684129_685530_+|sensor-histidine-kinase
MTASLPLPVRLLLSLLAATAAILLAASYYNYQRSMEVKRVLLQNKAAGIAQTIEALARKSPSRTPEELQSLIAAWPDDPDLFDLTVFDRNGMIIAHRDPARLGKEDVASLFLVRQVLAEQQMSFRYLKGHTPSASSTGAASGIPESPNHTPPASPLFEAFLPLHLGGFDGEGPRMAGDYQPRFKVLRVQLRESAAGDVSRAALWQLFLIGLVLLGTLTVTAYLVQTLRRYFTLEAQAREQARMASLGQVATWVAHEVRNPLGAIKGLLQLIQETIEERDPDGQSRRYCETAVRESERLERFVGDLLAYSRLPQPTITEWPLANLVQEITALLEPELARQDAAIVTQIEPPGLIVRADREQMHRLLLNLIQNALAAMPSGGDIHLRALSSPTEEGLSIIVEDEGIGLPPGAEHRLFEPFFTTREKGSGLGLAICRDIANRHGGTIRAEGAPGGGARFIVNLPEKGEL
>NC_010337.2|WP_012281820.1|683493_683796_+|hypothetical-protein
MSKNKPNSKASSQKETAATATAPATTTVKKYGPDNPNEELLKSPAVKLVAIAFGTAVSYIVGRMVQGGGPQEVPLGLYAAGFFLSTSLFLFVRSLLKKKK
>NC_010337.2|WP_187147801.1|692436_695061_+|S-layer-homology-domain-containing-protein
MRRRLISACVALSIVLSPTAGLAAVRQFGDVSTVMPEYRPIMKLSAQGTIKGRGDGNFGPSDPVKQLEALVMVQRFFGMEATATAAASRLTPDMEKKFGGNVPAWGKGYLVTAVNQNLLDANEYFPWHQGATRAWVARLLVRLLNKEQEAQSRMNAPLTFADATLIPASLRGHIAVATDLGLIRGRENGCFDPNSIVTRGEMAIFLDRAERKMDRLPPGIDEATFISGRDAILSVLDEENRLSSLTLDANARIFGTERAVALSDLNPQDKIRYIQDGDKVVYLEVVQGSGQKANVLRGEVIASLPEQGLLTLKDDAGKPFTYSLATSVSVIDLAGQMLSTSHVGPGSKAQLRLNNEGKIAEILLESVGQQGLYGTIVDINLTAKLLILSDGANHYSSYYLADNTTVEYNGKRFASLEDLAKGDLVSVEVDGSYVVNKIILQKPKSTVTVKGTVSLISRDSRLVTIKGDDGQLYAFELPETTALQFSDGTSAAIENLYLQDTVTLQLENGTVKKLVIVRAGNTKGLTGKIASIDANRRLLIVKDARDRLQSYEINDPVILDIEGNTKPTISNLGIDTSIEFELNADNKITYIKSKNTIEGVVTRVDADRHLITLRDAAGTEKIYTVETNAECQIFRRSGEDLDDIDVDDRVKVRVSGDKINRIQVHTQLTGEIIDKTSERIYIKDIDNNERSYTVNSTLKLIVPNIIKPSLSDVTIRQWAVVSYWGDEPYQIAVQTPVAGEVTGVDTGRDKLVIRQYDGSSRTLEKASPFKVDKGGTTSYGLSAISIGDRIQAFTDEQNRIMRAFVASKVSGKIDGINRTTKDIYIGTTVGYHIDSNTIITLNGVRKNFDDIQQKQSATIYYTGGYNAIEVNLSN
>NC_010337.2|WP_012281834.1|695245_699307_+|dynamin-family-protein
MKLTTNPLPASAIIPMLIERLQTLADRFRQSRDEHAAYAAETLIGKLRRRQLRIAFCGHVSGGKSALINALIGDDILPTSPIPSSANIVTVRSGPASARARLKSGETVELDLFANLSGVQEHCLDGTDTHSVDIAIPIDLFGCAVDLVDTPGVDSAEAARRLAEDPAIVAADVIFYVMDYNHVQSEINFSFTKRLKERGKPVFLIVNQIDKHCDFELDFDYFRRSSAASFAAWDIQPEGIFFTSLSDPSHPENELPRLKARLRDLFRHEEELLVASVLPATRQLIDDHCRRLAEADREERQRLQALLDAAEDLEEALQSYGQVSRRIDELQRAPQRLKEELDREIRRVVENARITPHTTSELARRYLESRSSGFKVGFLFSSEKTKKEIATRLAAVYADFRQHVSTQLEWHLRDVLARVAERHGVTDGEYIQRANSLTVHWGADLLARLVREGAVVGNEYVHNYTRDIAAEVKSLYRREALALAEEAVQLAKRAAARQIEQLTRQLEPLQPLVDAIKTLDKMEQAERKSRNELLAALHRGLPEVVPMESLLSPPPETADSAAGGTGGTAAAVSGTAPDPLAGLGQALREQSAPERAASGRSDFDLAADLLAAPALNAATGLSDGATPPILQHTAQRLRRCAAAVAPLPGFAHIAEELASRAERLEKNIFTVALFGAFSAGKSSVANALLGRPVLPVSPNPTTAAINKILPPNEENPHGTVRVRLKTAADIESDVLHSLSACDVAASNMAEALRRLHEISPGDIHPTAKPHYSFLRAVARGIGAVESRLGEEQIIDLDAFQDYVASEEKACFVEWIELYYRCPLTARGVMLVDTPGADSINARHTGVAFDYIKKADAILFVTYFNSAFSHADRDFLFQLGRVKDSFGLDKMFFLINAADLARSAGELAEVQRHVAERITACGISKPRLYTVSSQTALLARLGELGLLTASQKKTYRQRTNSLAAVRKAGTAREGIGGIGGGIGAGIEGGIEGGIEGSIEGSIEGSIEGSIEGSIADSAGLLPWSAAFSLSGYDRFEADFYGFTLHELTQIAVSAAEGDIQRCLAGLDDMIEAARLDASARRRQRVACETSRLEAERAVSAVSVDADGDLLDKEADELIYYVNQRIFYRFGDLYDRYFNPSVLQDSRGNITKQSMQHCLEELLQTLEKELAQEIRATSLRLEQFVHKRAGQYRNKLAQSIGAIDSRCALPAYEPVALPALEIPEQLSLSRSEALRVLPNGFGNPKDFFEGSGRNRLRSQLEESLRTPVQNYLSDASVVVKAIYAPLLAQRLEEARHRALQAVADHYAGLLAALDADFDLAAAEGIRADLAMHAGLGDESRFRQPATATAATSAWR
>NC_010337.2|WP_012281835.1|699411_700722_-|globin-coupled-sensor-protein
MFWRKSADESEPRPYRGPKPTISLQDPSFQLSVRFIKLTPEQLELLQEIRPILEQNVDAAVEAFYGHLGAMAEMREFIDRTTTVDRLKKTMRNYILSLAPMKIDDNYVFERYKIGKAHDRIALPPYWFTSAYQLHYNFLIPKIMDAYKDKERAKQAVTALLTITNLDQQLAMSSYIESYTSGLSKKEELERILNDLTSLQQQVNDASQSLAATAEETAASAAHMSTSVERITRNVTEAAKHSAEVVTLAKGGEGQLKEAVQAIRELSQLMLDMKQKIAALDVSSEKISSIAEVIQGIASQTNLLALNAAIESARAGEQGRGFNVVAQEVKKLAGSSEQSVKEIAEMIQQSRHHTADVSGSMEQNAKSMERVNELVDKVVQGFSQIIQSIALNQEQMRQISDEVVTLSTTAHEIENASESVAHSAEELAMMAQEIKQ
>NC_010337.2|WP_012281836.1|701071_701701_+|redox-sensing-transcriptional-repressor-Rex
MKMLKIPEPTVVRLSLYSRFLNQASSKGIDIISSDEIGAAVGIPSAQVRKDLSYFGEFGIRGVGYRVRELCSQVDKLLCVNQTWPVIIIGAGHLGLAMSGYRGLQDRGFDVIALFDANPAKQGELPNGLSVLPMERLAETVREKDIRIGIITVPADAAQQVAEALIAAGITAIINFAPTVLNVPPEVKVRNIDLTVNLEVLSFNLGMRG
>NC_010337.2|WP_012281837.1|701756_703034_-|PDZ-domain-containing-protein
MAPWDLIRLVLEAMEVLLLQPQEYPSFWVFLFIIALLYRRQSRLKAELFQLEREGWWRPVLYSAVYGVIAGFFGSLLMLFFGITIVAAGFIYLLPVALLLALINVRYMCYAYAGGLISLAALFMGWREVSAAQIMGLVAILHLVEALLIYLSGHLSRLPVFIAHRKGMTVGAFNLQSFWPIPLLVLTLLPVPVDSGLPWQEIATPDWWPLIAQPPFDYDAAKEIAVLFPLPIVALLGYGDLAVTRLPAAHARRSAAHLALYSAILLALAVVASNVPALAALPALFGPLGHEALILWSRRREMKGVPIFTPSLRGLRVLDIGAGSPADRLGLRAGDVVGRINGMTVLSKRDMAIALSWSPSDVDVEYLPGGQGTVWKRGSVVKGWKEPLGLIAAPDPEEPPLVKLETGGILARPLAWLLGLWRGRR
>NC_010337.2|WP_012281838.1|703177_704350_-|S41-family-peptidase
MAGRRSGPILFIVLVLLSSLLLTGSLAMAALGDAQNVGNLIKVVRLVTTEYLEPVSVNDLVNGAMKGMVAALKDPYSVYMEPKEYKHLTEQIEGAFTGIGVYINKKDTNQMVVVSPIKGGPAERAGLKSGDVIVKVNGEDVADMDVDVAVSKIKGPEGTEVNLTVFREASKSLLEFKINREKVNIPVVTAEIAKKDSHVGVLRISQFNMTASSEVDRAIQDFKDKKVKGIIMDLRDNPGGELRAAVNIASHFVPKGRVVSVVDREGRSENYETTREYINIPVVVLINGGSASASEIVAGAIKDSGTGALVGTKTFGKGVVQSLIELSGGAGVKLTTAKYLTPKGNDIHKIGIEPDVKVEAEKANGASAHGGEEADVQFDKGLETLRTMMR
>NC_010337.2|WP_012281839.1|704423_705599_-|M23-family-metallopeptidase
MRQRLLIRGLSAGLATALLLGIATPGVRLFPLNAAVADELQSKQQELDEVRSMIEKTRRELKEKERQHQGVLGKLAAVKSEMNRTEVALYDLNRKVKDVEGRIGTAEREIADAQKRQASQTEALKTRLKDMYINGSVSYLDVILQASSFTDFLTRMDLMEKIVESDARLIAKIEAEEKRIAERKAELERRRAELAQLREQTAAQKVLLAQQAQETQQVLAQVVNEKESIERMLDEEEAASRQLEAVIRSLQMKQNRPKMGSGPMAHPVPNNTAVSSPYGNRIHPVLKKARFHTGVDFPAPTGTPIHAAQTGVVAMAGYYGAYGNTVIIDHGGGTATLYGHMSVINVSDGQTVQKGDIIGQVGSTGWSTGPHLHFEVRVNGNHTNPMPYIGG
>NC_010337.2|WP_012281840.1|705640_706522_-|ABC-transporter-permease
MKVQTFGYFFREAFRSMWQNGWMSVASISTVAISLLILGISLLLVMNSHYAAAAIESDLEIVLSLKNDIDAKQTQAVADRLRGNSRVAEVIFVSKQEAMSAMRKQVRPELLRALGEDNPFPDQFRVKAKDPNDVASLADEFGKIPGVELVKYGQGVVERLLRLTQWVRIVGLSVMGLIGLAAVFLISTTIRLTVFARRREINIMKFVGATNWFIRWPFLLEGTFLGLIGSLLAIVLVYALYTPVAEYVRTSLPFVPLRADSGFLLTISQILLASGVFIGALGSSISLRKFLKV
>NC_010337.2|WP_012281841.1|706518_707217_-|cell-division-ATP-binding-protein-FtsE
MIQMFNVSKTYANGVQALVDVNVRIQKGSFVFLVGPSGAGKSTFIKLIFREEVPTRGQILFDGRSLVRMRESEVPYLRRQIGVVFQDFRLLPNKSVYDNVAFAMEIVEASSKRIRQRVPQVLEMVGLGKKSDLLPNQLSGGEQQRVSIARAIVNDPMLIIADEPTGNLDPETAQEIMNLLLEINRRGTTIIMATHAKDIVDSMRKRVIAIEGGRIVRDEERGSYEQERGLPR
>NC_010337.2|WP_041313211.1|707322_708267_-|transketolase-family-protein
MMKKIATRDAYGRALARLGGEKADLVVLDADLAKSTKTIDFAKVYPERFFDMGIAEQNLMGTAAGLAAVGKIPFASTFAMFATGRAFEQIRNSIAYPKLNVKIAATHAGITVGEDGASHQTVEDIALMRVLPNMTVIVPADGPETEGAIRWAAEHEGPVYIRLGRLGVPVINDEESYRFTPGKAVTLRQGRDVSLIATGLMVSIALEAAAALAAEAIEAEVLNIHTIKPIDAESILDSAVRTGCVVTAEEHSVIGGLGSAVAEVLGEGQPVPLERVGLKDTFGESGKPDLLLKKYGLTAEAVADAARRAMARKG

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Crispr_ID: NC_010337_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010337_6

718528-718622

Orphan

Consensus_repeat	Method
TTCAGTCGCTTGCGCTGCCGCCACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010337_6

>merge|NC_010337|6|718528-718622|CRISPRCasFinder
TTCAGTCGCTTGCGCTGCCGCCACAAGCGCCCGGTGACAATAGTTCCCGCCCCCCTCGGCAGCAGCAACCTTCAGTCGCTTGCGCTGCCGCCACA

>NC_010337|6|6|718528-718622|CRISPRCasFinder
TTCAGTCGCTTGCGCTGCCGCCACA	AGCGCCCGGTGACAATAGTTCCCGCCCCCCTCGGCAGCAGCAACC
TTCAGTCGCTTGCGCTGCCGCCACA

Protein	Signature genes	Signature genes Name	Protein_function
NC_010337.2\|WP_012281843.1\|708277_709096_-\|transketolase	unknown	unknown	gnl\|CDD\|238970
NC_010337.2\|WP_041313218.1\|731551_732157_-\|UDP-4-amino-4,-6-dideoxy-N-acetyl-beta-L-altrosamine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|274661
NC_010337.2\|WP_012281845.1\|710561_713093_-\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NC_010337.2\|WP_012281856.1\|726685_726988_+\|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein	unknown	unknown	gnl\|CDD\|225166
NC_010337.2\|WP_041314487.1\|715944_716667_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_010337.2\|WP_041313211.1\|707322_708267_-\|transketolase-family-protein	unknown	unknown	gnl\|CDD\|226467
NC_010337.2\|WP_012281858.1\|727471_728182_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236892
NC_010337.2\|WP_012281859.1\|728490_728955_+\|flagellar-export-chaperone-FliS	unknown	unknown	gnl\|CDD\|294015
NC_010337.2\|WP_012281841.1\|706518_707217_-\|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl\|CDD\|225438
NC_010337.2\|WP_049754023.1\|722525_726623_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_010337.2\|WP_012281849.1\|716765_717431_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_010337.2\|WP_012281857.1\|727002_727440_+\|YaaR-family-protein	unknown	unknown	gnl\|CDD\|377152
NC_010337.2\|WP_012281860.1\|729009_730308_+\|flagellin	unknown	unknown	gnl\|CDD\|236344
NC_010337.2\|WP_012281853.1\|721100_721880_-\|glycosyltransferase-family-protein	unknown	unknown	gnl\|CDD\|133011
NC_010337.2\|WP_148207069.1\|709325_710439_-\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NC_010337.2\|WP_012281847.1\|713980_715924_-\|motility-associated-factor-glycosyltransferase-family-protein	unknown	unknown	gnl\|CDD\|225324
NC_010337.2\|WP_083765268.1\|722037_722304_-\|SEC-C-domain-containing-protein	unknown	unknown	gnl\|CDD\|200353
NC_010337.2\|WP_012281861.1\|730413_731505_-\|GDP-mannose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|187566
NC_010337.2\|WP_083765267.1\|717622_718399_-\|basic-amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270342
NC_010337.2\|WP_012281846.1\|713334_713859_-\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461

Protein	Function_ID	Function_description	E-value
NC_010337.2\|WP_012281843.1\|708277_709096_-\|transketolase	gnl\|CDD\|238970	cd02012, TPP_TK, Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.	1.86629e-153
NC_010337.2\|WP_041313218.1\|731551_732157_-\|UDP-4-amino-4,-6-dideoxy-N-acetyl-beta-L-altrosamine-N-acetyltransferase	gnl\|CDD\|274661	TIGR03585, PseH, UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase. Sequences in this family are members of the pfam00583 (GNAT) superfamily of acetyltransferases and are proposed to perform a N-acetylation step in the process of pseudaminic acid biosynthesis in Campylobacter species. This gene is commonly observed in apparent operons with other genes responsible for the biosynthesis of pseudaminic acid and as a component of flagellar and exopolysaccharide biosynthesis loci. Significantly, many genomes containing other components of this pathway lack this gene, indicating that some other N-acetyl transferases may be incolved and/or the step is optional, resulting in a non-acetylated pseudaminic acid variant sugar.	3.77458e-28
NC_010337.2\|WP_012281845.1\|710561_713093_-\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NC_010337.2\|WP_012281856.1\|726685_726988_+\|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein	gnl\|CDD\|225166	COG2257, COG2257, Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown].	5.67062e-31
NC_010337.2\|WP_041314487.1\|715944_716667_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	6.25259e-161
NC_010337.2\|WP_041313211.1\|707322_708267_-\|transketolase-family-protein	gnl\|CDD\|226467	COG3958, COG3958, Transketolase, C-terminal subunit [Carbohydrate transport and metabolism].	4.28317e-152
NC_010337.2\|WP_012281858.1\|727471_728182_+\|hypothetical-protein	gnl\|CDD\|236892	PRK11281, PRK11281, mechanosensitive channel MscK.	0.000221211
NC_010337.2\|WP_012281859.1\|728490_728955_+\|flagellar-export-chaperone-FliS	gnl\|CDD\|294015	cd16098, FliS, flagellar export chaperone FliS. This family contains flagellar export chaperone FliS, a protein critical for flagellar assembly and bacterial colonization. FliS prevents premature polymerization of flagellins, the major protein of the filament, by regulating interactions between structural components of the bacterial flagellum in the cytosol. It binds specifically to FliC (flagellin) which is sequentially secreted in large numbers through the central channel of the flagellum and polymerized to form the tail filament. FliS protects FliC from degradation and aggregation by binding to the FliC C-terminal helical domain, which contributes to stabilization of flagellin subunit interactions during polymerization. FliS has been shown to interact specifically with FlgM, whose role is to inhibit FliA, a flagellum-specific RNA polymerase responsible for flagellin transcription; FliA competes with FliS for FlgM binding.	1.34313e-23
NC_010337.2\|WP_012281841.1\|706518_707217_-\|cell-division-ATP-binding-protein-FtsE	gnl\|CDD\|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	2.82738e-129
NC_010337.2\|WP_049754023.1\|722525_726623_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	2.94198e-16
NC_010337.2\|WP_012281849.1\|716765_717431_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	2.63121e-89
NC_010337.2\|WP_012281857.1\|727002_727440_+\|YaaR-family-protein	gnl\|CDD\|377152	pfam03885, DUF327, Protein of unknown function (DUF327). The proteins in this family are around 140-170 residues in length. The proteins contain many conserved residues. with the most conserved motifs found in the central and C-terminal region. The function of these proteins is unknown.	3.82831e-42
NC_010337.2\|WP_012281860.1\|729009_730308_+\|flagellin	gnl\|CDD\|236344	PRK08869, PRK08869, polar flagellin E.	1.86982e-81
NC_010337.2\|WP_012281853.1\|721100_721880_-\|glycosyltransferase-family-protein	gnl\|CDD\|133011	cd02518, GT2_SpsF, SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat. Spore coat polysaccharide biosynthesis protein F (spsF) is a glycosyltransferase implicated in the synthesis of the spore coat in a variety of bacteria challenged by stress as starvation. The spsF gene is expressed in the late stage of coat development responsible for a terminal step in coat formation that involves the glycosylation of the coat. SpsF gene mutation resulted in spores that appeared normal. But, the spores tended to aggregate and had abnormal adsorption properties, indicating a surface alteration.	2.2716e-95
NC_010337.2\|WP_148207069.1\|709325_710439_-\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_010337.2\|WP_012281847.1\|713980_715924_-\|motility-associated-factor-glycosyltransferase-family-protein	gnl\|CDD\|225324	COG2604, COG2604, Uncharacterized protein conserved in bacteria [Function unknown].	1.93868e-54
NC_010337.2\|WP_083765268.1\|722037_722304_-\|SEC-C-domain-containing-protein	gnl\|CDD\|200353	TIGR04102, SEC-C_motif_domain_protein, SWIM/SEC-C metal-binding motif protein, PBPRA1643 family. Members of this protein family have a SWIM, or SEC-C, domain (see pfam02810), a 21-amino acid putative Zn-binding domain that is shared with SecA, plant MuDR transposases, etc. This small protein family of unknown function occurs primarily in marine bacteria.	1.17274e-24
NC_010337.2\|WP_012281861.1\|730413_731505_-\|GDP-mannose-4,6-dehydratase	gnl\|CDD\|187566	cd05256, UDP_AE_SDR_e, UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs. This subgroup contains UDP-N-acetylglucosamine 4-epimerase of Pseudomonas aeruginosa, WbpP, an extended SDR, that catalyzes the NAD+ dependent conversion of UDP-GlcNAc and UDPGalNA to UDP-Glc and UDP-Gal. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.65154e-82
NC_010337.2\|WP_083765267.1\|717622_718399_-\|basic-amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270342	cd13624, PBP2_Arg_Lys_His, Substrate binding domain of the arginine-, lysine-, histidine-binding protein ArtJ; the type 2 periplasmic binding protein fold. This group includes the periplasmic substrate-binding protein ArtJ of the ATP-binding cassette (ABC) transport system from the thermophilic bacterium Geobacillus stearothermophilus, which is specific for arginine, lysine, and histidine. ArtJ belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.16656e-98
NC_010337.2\|WP_012281846.1\|713334_713859_-\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	8.11891e-34

>NC_010337.2|WP_083765267.1|717622_718399_-|basic-amino-acid-ABC-transporter-substrate-binding-protein
MGMLALGMLITAAGCGGGEKAAQAPTGDKSSAKKTIKVATDAAYAPFEWKDEKGEIVGFDIDLIKAVGKELNADIELIDTPFDGIIAALTNKNVDMLISAMTITEKRKESIDFSKPYFVAVQAIAVKEGSPVKKFDDIKGLKVGVQNSTTGQYVVEKLLGEKSDKIFRYDTTPMAMNMLSNGDVDVVVADKPVVQHFLKNNPNAKMTLIDDASFEKEEYGIAVRKGETELLKQVNDALDKLEKSGKIKEISEKYLTGK
>NC_010337.2|WP_012281849.1|716765_717431_-|amino-acid-ABC-transporter-permease
MDFKWKIVQDYADLFLMGGWTTVKVTAISVMIGTVIGLFIALARLSHWRLLRWVAAIYTDVIRGTPLLVQIFIVHLGAPKLIGQSLPAMTSGLIALSVNSGAYVAEIFRAGIQSIDKGQMEASRSLGMSYGQAMRFVILPQAFRRVIPPLGNEFIAMLKDSSLVSVISLPELTMAGRTVLGSTARVWEAWLPVAAIYLTLTLLFSRLVAWYEQKLSVKSHR
>NC_010337.2|WP_041314487.1|715944_716667_-|amino-acid-ABC-transporter-ATP-binding-protein
MIEIKGLHKKFGALHVLRGVDMKVQEREVVCIIGPSGSGKSTLLRCINHLEEPTEGYITVDEILLTHKETDINRVRAEVGMVFQRFNLFPHMTVLQNITLAPVQVRKMAKGEAESLARELLAKVGLSEKEQAYPEQLSGGQQQRVAIARALAMRPKIMLFDEPTSALDPEMVGEVLNVMKDLAREGMTMVVVTHEMGFAREVGDRVIFMDEGVIVEEGTPEQLFGQAQQERTRAFLSKVL
>NC_010337.2|WP_012281847.1|713980_715924_-|motility-associated-factor-glycosyltransferase-family-protein
MQRRLPPYVQYLSDEIFAGNIQALATVQPPLAERMARYKPPYNQPFQVEPAQSGDLTLLVDTGRERLFLLSPVDPCKQAREWVAEVAGAPSSLLVVFGFGLGYTIEVLRQIIPSQGKMVVFERSIDLFWLALWTVDLRHVLADSRIRFAIDVDAASVGPIMHRLNLSASDALTAQLYEFHYLTALFDGYYDQVKGALQEYFQTQQIAVATENYFSLTWTLNFLQNLPAVLSACPVQHLYGRFPALPAVVIAAGPSLEKNLEGLREFARYGLLIATAPTLRVLQQRGIRPHLLLSIDGGAPNYSHFQGLAVDDVPLVFDATLYPPILKAYGGGGKRFALLAYDKAELYGILDGAVDVAAASVNVGASVANLGLVLAYRSGCDPIVFVGQDLAFTGNHSHISGSAFDSAVDEAGMSRYIEMDDIYGQKTYTQETWLAFREWFRWFIKGHPDRRYINATEGGIGIPGTEVATLAAVIGQLRETKASQGRNASDQAIAAAFLQGVQAASQGAAQRDAQIVKKLKNLHGHLRRILEGCEKGQELIAKYQRFVTSRVDIDKPFAQYYRKLDKIRRQIEGDHEAMGFLRLAFRPIVNQLEQSAILADVTDKREALAHDLMRGQLFFIEVGRRSGAILAQVERTMAVLQSPDRGS
>NC_010337.2|WP_012281846.1|713334_713859_-|ribosome-associated-translation-inhibitor-RaiA
MNIQVRGKNIEVTNALKEYVVKRLSKLEKYFHNIGGARTTLAVEGDMAKVEVTVPAGDLLLRAEESHPDMYAAIDLVFEKLEKQVDAYKTKLSRRLKGQGFKEFAAAEKNGATEPRVVRSKRFALKPMPVDEAIMQMNLIGHSFFVFSNAETEQVNVVYLRKDGNYGLIEPEFD
>NC_010337.2|WP_012281845.1|710561_713093_-|preprotein-translocase-subunit-SecA
MFGFLKNLLDDNARDIRRLQKTVDRINSMEPEWQRLSDADLQHKTVEFRQRLENGESLDDLLPEAFATVREASRRVLGMRHFDVQLIGGMVLHQGRIAEMRTGEGKTLVATLPSYLNALTGRGVHVVTVNDYLAKRDAEWMGRIHRFLGLQVGLIIHGLDFAERREAYAADITYGTNNEFGFDYLRDNMVIQPQHMVQRELHYAIVDEVDSILIDEARTPLIISGQANKPTEKYYAVARIIPRLTKDVDYKVDEKAHSVVLTEEGVSRVEKMLGIDNLADSLDWAHHVNQGLKAHALMRRDRDYVVKDGEVIIVDEFTGRLMFGRRYSEGLHQAIEAKEGLEIQNESQTLATITLQNYFRMYDKLSGMTGTAKTEEPEFMQIYKMDVVQIPTNKPMQRKDLPDVVYRTEEGKFNAVVEEIVQSFRRGQPVLVGTVSIEKSEQLSDKLKRRGVPHQVLNAKHHEKEAEIVKNAGQRGMVTIATNMAGRGTDIILGEGVAELGGLYVIGTERHEARRIDNQLRGRSGRQGDPGQTRFYVSLEDDLMRLFGAENIQGVMDRLGMDDSMPIESGMITRAIENAQRRVEARNFDIRKHVLQYDDVMNQQREVIYDQRKKVLNGENLRDTVFDFIDTLVENMVNRFAGEEKYVENWDLPAMLAYAEETFQIAVTAEDLHEMEKEEVIAFFQEKAQERYSQREQELGLETIRELERIILLRVVDSHWMDHLDAMDHLRHGIGLRAYGQKDPLVEYKYEAYSMFQEMIASVQEEFLRYMFRVNVVVAQAEEEKQEAEAEAEAETVLKNAVENRSDDSLPKQPVKAEPRVGRNDPCPCGSGKKYKKCCGVKG
>NC_010337.2|WP_148207069.1|709325_710439_-|peptide-chain-release-factor-2
MFSEVKRELGLLETRLDELRDSLDLAVKEERIAELEQMIQEPGFWDDTERAQKTMQELTGLKDKVKAYRDLRSQWEDLCVLRELGAEENDAEILAEIEAGIQTITAELDRWHLELLLNGPYDRNNALLTLHAGAGGTEAMDWNEMLLRMYIRWGEKRGYKVELLDSLPGDEAGIKSATLSVVGENAYGYLKGEMGVHRLVRISPFDSSGRRHTSFASLEVLPEVSDGAEIQIRPEDLKVDTFRAGGAGGQHVNKTESAVRITHIPTGIVVACQSERSQIQNRATAMRMLQAKLFERQRQEQEAEVNRLKGDQQDIAFGSQIRSYVFHPYNLVKDHRTNTEVGNVHAVMDGELDEFISAYLVWSTKQDNRL
>NC_010337.2|WP_012281843.1|708277_709096_-|transketolase
MSEAIIQRLEATARQIRRHIIAMTHAAGSGHPGGSLSAADMVTALFFKEMRIDPQNPRWPDRDRFVLGKGHAAPVLYAALAERGFFPAEELKGLRQTGHFLQGHPDMKKVPGVDMSTGSLGQGLSAAVGMALGLRLDKKDARVWALLGDGELQEGQVWEAAMAAAHYKLDKLAIFIDDNGLQIDGPVKEVMSSYPIVDKFRAFGWNVIEIDGHAMPAILEAIERAKAATGRPTCIVAHTVKGKGVSFMEDQVGWHGTAPNAEEAAIALKELQ
>NC_010337.2|WP_041313211.1|707322_708267_-|transketolase-family-protein
MMKKIATRDAYGRALARLGGEKADLVVLDADLAKSTKTIDFAKVYPERFFDMGIAEQNLMGTAAGLAAVGKIPFASTFAMFATGRAFEQIRNSIAYPKLNVKIAATHAGITVGEDGASHQTVEDIALMRVLPNMTVIVPADGPETEGAIRWAAEHEGPVYIRLGRLGVPVINDEESYRFTPGKAVTLRQGRDVSLIATGLMVSIALEAAAALAAEAIEAEVLNIHTIKPIDAESILDSAVRTGCVVTAEEHSVIGGLGSAVAEVLGEGQPVPLERVGLKDTFGESGKPDLLLKKYGLTAEAVADAARRAMARKG
>NC_010337.2|WP_012281841.1|706518_707217_-|cell-division-ATP-binding-protein-FtsE
MIQMFNVSKTYANGVQALVDVNVRIQKGSFVFLVGPSGAGKSTFIKLIFREEVPTRGQILFDGRSLVRMRESEVPYLRRQIGVVFQDFRLLPNKSVYDNVAFAMEIVEASSKRIRQRVPQVLEMVGLGKKSDLLPNQLSGGEQQRVSIARAIVNDPMLIIADEPTGNLDPETAQEIMNLLLEINRRGTTIIMATHAKDIVDSMRKRVIAIEGGRIVRDEERGSYEQERGLPR
>NC_010337.2|WP_012281853.1|721100_721880_-|glycosyltransferase-family-protein
MSTAIIVQARMGSTRLPGKVLAPLAGQPALWHTLERLKRVREAQVLAVATGDGTADDPIADAARQWGVFVFRGSETDVLARYVGCAQKVDAAVIVRITADCPLIDPDVVGAAIGEFRNRSLDYLSVEGGPRGLDTEVFTREALERAHRQGRYPAAREHVTFHLYHSGLFRTGSWQLPGPYRRSRYRLCVDEPLDYQLLAEIYERFYRPGRIIAVPEVLAWLDEHPQWALLNQSVRQKAVSDEELLPQGEDDRWEAQHLR
>NC_010337.2|WP_083765268.1|722037_722304_-|SEC-C-domain-containing-protein
MGTPKRPLVLRVATEKRGMEIMEICNERGLHYIIAFEPDKPEDLSDLERVLNPARPAVAGPKIGRNDPCPCGSGKKYKKCCGNGTLPG
>NC_010337.2|WP_049754023.1|722525_726623_+|hypothetical-protein
MRIQSPSTGTTRSDMEQPLELRQGDVYTGTIKKITASQEGIVQIRGQEQQVRFEGALPKSDRFTLQVTAVDGDVARIKVIEDLPSGAAATRHSEGNIGRLLRTFGVSPSEELSQAARQIIERGRPLTQETVQELNAFFEKTPGPAADKIDTVQALLRKNLEITAPQLKAVHEALHGRPIGQVLTDLVKQLDPTWQLPATVRQEPDLAKAIRQLQSTVAANRDIATDLASKVQQQLDSARQLQQQGYESLARENLARSLEQLARQLPDRTAAPAAATDHAQTLQTQPMQPPQGAPTPAAFAAAFAAPTTQPQPAPPAQQPPTTPAALPSAIVPPTTTPTAATTAATTAATAAATATATTAATAATTTAATTATAANTAAATTATTTAATTAATAIATTATTTAAATATAATTAAATTAATTATTTAATATEQIAQVLSRLSPHSPINEVIETVQELSRQWAADDKIPRPAITTLERSLSEARIYAAMGRQSDSLERLQQALSATAKAIAPTVPATTTPPTTATPTTSTNPTTTTTPTTPPASAQVGATRPSLPQGILTDAAATVRQEPDLAKAIRQLQSTVAANRDIATDLASKVQQQLDSARHLQQQGYESLARENLARSLEQLARQLPDRTAAPAAATGQAQTLQTQPMQPPQGAPTPAASTAAFAAPTTQPQPAPPAQQPPTTPAALPSAIVPPTTTPTAATTAATTATTATTTAAATATAAATTATTTAATTATTAAATAATTTAATTATTTAAATATAAATTATTTAATTATTAAATATEQIAQILSNLSPHSPINEVISATQTLSRQLSTGTPKEGALASSLNRALSEAQILATIGQEQKGKERLSQGLTQTLHALLRLAPTPSPSSAAPSPMTDKATTLPTPPTAGTFDPPEAPLPPAPLTEENDSTAIVNKAYKDALAMGGIALPAKNYMITEITRQLNQAAQDFRDLKREVTRNIDNIRQIVQNHRNNVLPMVKPLLESTIDLLDNAILKSDITLFTDMTTEKKLMVASSRLAEARTLLQQGHNQKAHDILTEVRDQLEQMNWRPADIKVRRILTDSGLFRFDKDPATPLGRQMNHVLSAPAPTQSLYTSTASPLPNPTATEPSARDIYNLLRTLGLNHDSEIAQTIATHNQKTPASEPASHQPSRQPGRDGDKGNPGSQQQPEARPDQGHSNLKSTLLQLAKSDSPLPPGLQSLAEQALNNLTGQQLLSKTDVGTTMQSLFFSLPMLLGNQVKNLKIWVNGRNERQKIDWENCNLYFLIDTPKYGETGIVVSAVDRNLAITLKNDTDHFKANMSPLVEKCKESMKKIGYTISSVQFTRLNEEKSKPTPPEALSQLPITPGVKVPGTIHPGGFSFKI
>NC_010337.2|WP_012281856.1|726685_726988_+|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein
MNFRFFNQKQKKEIGGPSVAALRYDPNSDAPVVIAQGKGHLARKIIEMAKEKNIPIQEDPLLVENLIDMDLGDTIPPQLYLVVAEILLMIEEMEGTQNKS
>NC_010337.2|WP_012281857.1|727002_727440_+|YaaR-family-protein
MEVNKIGKTTPTSKKNTNDIPADKISFAEIMVQQREQRSIDKFVKMAEKIEDQGKILAESRTVEDLKKYKELVKQFMDEVIKKGLQLEERRGFNRRGRAKIYKLITKVDEKLLELTDHVLKKQANSLKILGLVGEIKGLLVDMYT
>NC_010337.2|WP_012281858.1|727471_728182_+|hypothetical-protein
MTNEEFQSQVLTQLQTLTSEVRSVKETQEAMLERQDKLEQGQALLLERQDKLEQGQALLLERQDKLEQGQALLLERQDKLEQGQALLLERQDKLEQGQALLLERQDKLEQGQALLLERQDKLEQGQALLLERQDKLEQGQALLLERQDKLEQGQALLLERQDKLETEMNRRFDELTSMIARRFDEGDGLLNSRIDKLEEKIARIEENQQTQHRILLQLSYNSIKHEADIQELRRIK
>NC_010337.2|WP_012281859.1|728490_728955_+|flagellar-export-chaperone-FliS
MDRIPTEQEIFQMSSQEITLLLYQNLTERLQLSIAAIREKKFNEANIQLQKANAIVERLGAGINYEAGAMAEQLDALYNYVADRLYEANWKKDISIIEELLRILTPVAEAWEQMLKEKPTTRAEQIRLQTSAYERNLAYDDAETIHNGFINRRE
>NC_010337.2|WP_012281860.1|729009_730308_+|flagellin
MRINHNIQALNAYRQLNNNQGIVSKHMEKLSSGLRINRASDDAAGLAISERMRSQIRGLTVAERNGLDGVSLIQTAEAALDSVHQMLQRMRELAVQSANGIYTEQDRSALQDEVDELIKEIDRVAGHTEFNTRKLLNGNMGKAVSGAVANIQTNNLVTSGGKVFSGAAKLVNLSDRAGNKFGVVSGDTVQLSFVVNGKLLQTSGIKISGGTTFNSVIGAAVKDINGSSAGNVSGYFKLTVSGTKLHFTAVSGGYAKAVYGITFTFRDAQGIMKTPATDALSSFHETRQALVSRPPGDATLQIGPNTNQHLGLEIGDVTSAALGLKSYSGAEFNIKINTQQDANIAIKVFDEAIAKVSKERSKLGAFQNRLEYTINNLKVANESLTAAESRIRDTDMAMEMTQFTKQNIISQSATAMLAQANQLPQGILQLLK
>NC_010337.2|WP_012281861.1|730413_731505_-|GDP-mannose-4,6-dehydratase
MNILVTGGAGFIGRWVVLQLLRAGHHVWVVDDLSNGRAENLAYGDEALVGSDSLADPCCTGIVTGTLIFEVGDICDRERLRRWFEEHRFDLCYHLAAEINVQKSIDFPADTFRRDVEGTFGLLELCREFGTRFVFMSTCMVYAPFEEAAADRASRRGLELADGQGMNGCGYGDGGAPAGIDERHPVLPASPYAGAKLSGEHLALSYYHAYGLPVTVIRPFNTYGPYQKTNGEGGVVAIFVERALREEPLHIFGDGTQTRDLLYVEDCARFVIQAGMDRQAIGKTLNAGSGRDVSINELARLVGEVVQAGPGFSVCHVAHPHPQSEIRRLLCDFGEAKRLLGWEPQVSLEEGIARTADWIQGKQ
>NC_010337.2|WP_041313218.1|731551_732157_-|UDP-4-amino-4,-6-dideoxy-N-acetyl-beta-L-altrosamine-N-acetyltransferase
MSDVAVTVDVIYGRRVRLRVVEAEDLERVRCWRNSPEVYYPMYNWDPITAEMQRHWYETRVLKRERHHYFLVERFVPGESNYRPVGLISLTDVDGRHRRGDVGFYIANAEDRLPGVALEAEYMLLSFAFDQLGLHKVCLEVIQGNDKVAKMHRHYGFELEGRLRGHVWHDGVFKDVLVMGLLASDFAAHREKIEALLERLA

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Crispr_ID: NC_010337_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010337_7

905823-906018

Orphan

Consensus_repeat	Method
GTCTAACCGAAAACCGCGCCGGCTATTCGAGGCTACCAACCGGCATCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010337_7

>merge|NC_010337|7|905823-906018|CRISPRCasFinder
GTCTAACCGAAAACCGCGCCGGCTATTCGAGGCTACCAACCGGCATCGCCCGGGATGCCGCCAATTCCGTCACCGTCTAACCGAAAACCGCGCCGGCTGTTCGAGGCTACCAACCGGCATCGTCCGGGATGCCGCCAATTCCGTCACCGTCTAACCGAAAACCGCGCCGGCTGTTCGAGGCTACCAACCGGCATCG

>NC_010337|7|7|905823-906018|CRISPRCasFinder
GTCTAACCGAAAACCGCGCCGGCTATTCGAGGCTACCAACCGGCATCG	CCCGGGATGCCGCCAATTCCGTCACCGTCTAACCGAAAACCGCGCCGGCTGTTCGAGGCTACCAACCGGCATCGTCCGGGATGCCGCCAATTCCGTCACC
GTCTAACCGAAAACCGCGCCGGCTGTTCGAGGCTACCAACCGGCATCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_010337.2\|WP_012282017.1\|899480_900122_-\|manganese-efflux-pump	unknown	unknown	gnl\|CDD\|308338
NC_010337.2\|WP_012282021.1\|903602_904568_-\|DUF1385-domain-containing-protein	unknown	unknown	gnl\|CDD\|377780
NC_010337.2\|WP_049754034.1\|913347_914598_-\|alanine-racemase	unknown	unknown	gnl\|CDD\|143481
NC_010337.2\|WP_012282019.1\|901609_902503_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	unknown	unknown	gnl\|CDD\|236467
NC_010337.2\|WP_012282020.1\|902509_903574_-\|peptide-chain-release-factor-1	unknown	unknown	gnl\|CDD\|234801
NC_010337.2\|WP_012282028.1\|909760_910426_-\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012282014.1\|897930_898470_-\|TIGR01440-family-protein	unknown	unknown	gnl\|CDD\|377271
NC_010337.2\|WP_012282018.1\|900218_901487_-\|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl\|CDD\|223088
NC_010337.2\|WP_012282026.1\|908085_908733_-\|fructose-6-phosphate-aldolase	unknown	unknown	gnl\|CDD\|234947
NC_010337.2\|WP_049754224.1\|914619_915639_-\|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	unknown	unknown	gnl\|CDD\|225224
NC_010337.2\|WP_012282027.1\|908744_909599_-\|class-II-fructose-1,6-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|237235
NC_010337.2\|WP_012282024.1\|906039_906531_-\|DUF2062-domain-containing-protein	unknown	unknown	gnl\|CDD\|378263
NC_010337.2\|WP_012282022.1\|904623_904821_-\|50S-ribosomal-protein-L31	unknown	unknown	gnl\|CDD\|376487
NC_010337.2\|WP_083765103.1\|911181_912084_-\|YIP1-family-protein	unknown	unknown	gnl\|CDD\|377418
NC_010337.2\|WP_083765101.1\|904959_905781_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NC_010337.2\|WP_012282025.1\|906710_907694_-\|class-II-fructose-bisphosphatase	unknown	unknown	gnl\|CDD\|236536
NC_010337.2\|WP_012282012.1\|895907_896537_-\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
NC_010337.2\|WP_148207163.1\|912345_913134_-\|signal-peptide-peptidase-SppA	unknown	unknown	gnl\|CDD\|132934
NC_010337.2\|WP_012282029.1\|910485_910872_-\|response-regulator	unknown	unknown	gnl\|CDD\|333815
NC_010337.2\|WP_012282013.1\|896596_897838_-\|serine-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234571

Protein	Function_ID	Function_description	E-value
NC_010337.2\|WP_012282017.1\|899480_900122_-\|manganese-efflux-pump	gnl\|CDD\|308338	pfam02659, Mntp, Putative manganese efflux pump. MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organisms from bacteria to humans, and acts as an important element in the defense against oxidative stress and as an enzyme cofactor.	2.13776e-32
NC_010337.2\|WP_012282021.1\|903602_904568_-\|DUF1385-domain-containing-protein	gnl\|CDD\|377780	pfam07136, DUF1385, Protein of unknown function (DUF1385). This family contains a number of hypothetical bacterial proteins of unknown function approximately 300 residues in length. Some family members are predicted to be metal-dependent.	2.0191e-132
NC_010337.2\|WP_049754034.1\|913347_914598_-\|alanine-racemase	gnl\|CDD\|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	4.02218e-134
NC_010337.2\|WP_012282019.1\|901609_902503_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	gnl\|CDD\|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	1.75601e-122
NC_010337.2\|WP_012282020.1\|902509_903574_-\|peptide-chain-release-factor-1	gnl\|CDD\|234801	PRK00591, prfA, peptide chain release factor 1; Validated.	0
NC_010337.2\|WP_012282014.1\|897930_898470_-\|TIGR01440-family-protein	gnl\|CDD\|377271	pfam04260, DUF436, Protein of unknown function (DUF436). Family of bacterial proteins with undetermined function.	7.59613e-97
NC_010337.2\|WP_012282018.1\|900218_901487_-\|threonylcarbamoyl-AMP-synthase	gnl\|CDD\|223088	COG0009, SUA5, Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis].	3.32408e-92
NC_010337.2\|WP_012282026.1\|908085_908733_-\|fructose-6-phosphate-aldolase	gnl\|CDD\|234947	PRK01362, PRK01362, fructose-6-phosphate aldolase.	5.36951e-147
NC_010337.2\|WP_049754224.1\|914619_915639_-\|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	gnl\|CDD\|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	4.47687e-63
NC_010337.2\|WP_012282027.1\|908744_909599_-\|class-II-fructose-1,6-bisphosphate-aldolase	gnl\|CDD\|237235	PRK12857, PRK12857, class II fructose-1,6-bisphosphate aldolase.	0
NC_010337.2\|WP_012282024.1\|906039_906531_-\|DUF2062-domain-containing-protein	gnl\|CDD\|378263	pfam09835, DUF2062, Uncharacterized protein conserved in bacteria (DUF2062). This domain, found in various prokaryotic proteins, has no known function.	2.78745e-22
NC_010337.2\|WP_012282022.1\|904623_904821_-\|50S-ribosomal-protein-L31	gnl\|CDD\|376487	pfam01197, Ribosomal_L31, Ribosomal protein L31.	2.98573e-34
NC_010337.2\|WP_083765103.1\|911181_912084_-\|YIP1-family-protein	gnl\|CDD\|377418	pfam04893, Yip1, Yip1 domain. The Yip1 integral membrane domain contains four transmembrane alpha helices. The domain is characterized by the motifs DLYGP and GY. The Yip1 protein is a golgi protein involved in vesicular transport that interacts with GTPases.	1.63318e-11
NC_010337.2\|WP_083765101.1\|904959_905781_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	6.26919e-43
NC_010337.2\|WP_012282025.1\|906710_907694_-\|class-II-fructose-bisphosphatase	gnl\|CDD\|236536	PRK09479, glpX, fructose 1,6-bisphosphatase II; Reviewed.	0
NC_010337.2\|WP_012282012.1\|895907_896537_-\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	1.11817e-130
NC_010337.2\|WP_148207163.1\|912345_913134_-\|signal-peptide-peptidase-SppA	gnl\|CDD\|132934	cd07023, S49_Sppa_N_C, Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad. Signal peptide peptidase A (SppA; Peptidase S49; Protease IV): SppA is found in all three domains of life and is involved in the cleavage of signal peptides after their removal from the precursor proteins by signal peptidases. This subfamily contains members with either a single domain (sometimes referred to as 36K type), such as sohB peptidase, protein C and archaeal signal peptide peptidase, or an amino-terminal domain in addition to the carboxyl-terminal protease domain that is conserved in all the S49 family members (sometimes referred to as 67K type), similar to E. coli and Arabidopsis thaliana SppA peptidases. Site-directed mutagenesis and sequence analysis have shown these SppAs to be serine proteases. The predicted active site serine for members in this family occurs in a transmembrane domain. Mutagenesis studies also suggest that the catalytic center comprises a Ser-Lys dyad and not the usual Ser-His-Asp catalytic triad found in the majority of serine proteases. Interestingly, the single membrane spanning E. coli SppA carries out catalysis using a Ser-Lys dyad with the serine located in the conserved carboxy-terminal protease domain and the lysine in the non-conserved amino-terminal domain.	7.51399e-102
NC_010337.2\|WP_012282029.1\|910485_910872_-\|response-regulator	gnl\|CDD\|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	6.70001e-28
NC_010337.2\|WP_012282013.1\|896596_897838_-\|serine-hydroxymethyltransferase	gnl\|CDD\|234571	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed.	0

>NC_010337.2|WP_083765101.1|904959_905781_-|M23-family-metallopeptidase
MTPMQRDGRHPGGVYRLLLFTLLFCLLPLPGAGFAAEGDLWRLLKGDLVYEAKTAPGPTAAEGLSVRPAEGAAERWTLHRVAPGETLYGIARIYGFSVAQLQEMNGLKTGLLQPGQPLRLPLSGDPAFCEGRRDTDGGNPSRGAILSSLVTPLEGTVTSPYGPRRGVFHHGIDIAADKGETIRAAQRGRVVFAGWKAVYGQTVIIEHPFGVATLYAHSSKILVNEGERVERGRPIAQVGATGVATGPHLHFEVRLDSRAVNPAAYLRGASADL
>NC_010337.2|WP_012282022.1|904623_904821_-|50S-ribosomal-protein-L31
MKEGIHPQVHRAKVHCACGESFETTSTRKEIKVDVCSKCHPFFTGKSRTVEVGGRVDRFKKKYGL
>NC_010337.2|WP_012282021.1|903602_904568_-|DUF1385-domain-containing-protein
MGNFQYGGQAVIEGVMMRGPDEMAIAVRCPNGEIVTEKRPVASWMNGALMRTPILRGTGALLDALILGIKALSFSAGKATEEEEEELTPWEITATVAVSMVLGAGLFIFLPTAAAHLTRQMVPNLFFQNVIEGFVRIAIFFGYIAAISRMPDIQRVFQYHGAEHKVIHAYEAGEELTVANAQRQTTLHPRCGTSFLLFVMVIKIFAFSLLPDATLFWKVIYRLGLVPFVAGISYEIIKLSGRYRRFWLMRLFIQPGLWLQRMTTREPDDQQVEVAIRALQAVLPQAAPSLDVTVKEGCFQRRKGAAEEEPAAACTAAGGAG
>NC_010337.2|WP_012282020.1|902509_903574_-|peptide-chain-release-factor-1
MIDKLEIIEQKYDELTQLLSDPEIIQDQTRWQRHAKQQAGMTEIVDTFRAYKGVLQGIDDARAMLAESDPELQEMASLELDELLARKEELEQRLKVLLLPKDPNDDKNVIIEIRAGTGGEEAALFAGDLYRMYSRFADRQGWRTELLSANYTDIGGFKEVIVLIEGQGAFSKLKFESGVHRVQRVPATESSGRIHTSAATVAVLPEAEEVEIEVNPNELRIDVFCSSGAGGQHVNKTESAVRITHLPTGIVVSCQDEKSQLKNREKAMRVLRARLLEKAREEQHGEMASARKSMVGSGDRSERIRTYNFPQGRVTDHRIGLTLHRLETILDGDLDELLDALITTDQAEKLKTME
>NC_010337.2|WP_012282019.1|901609_902503_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase
MDRWEWKPATVGEALQAAVSFFTQSEIPSPRLEAEVLLAYGLGVSRAGLLAMLRDQLTDAQQARLGELIQRRLTGCPLQYITGRQEFWGLDFAVTPAVLIPRPETELLVETALALLGRQDRTAWIADVGVGSGAIAVAMARERPRLQVLATDLSEAALAVARQNAKRHGVAGQIRFARGDLLDPAIDAAIRLKAVLSNPPYIPSGHIPSLQREVAGFEPKLALDGGEDGLDLYRRLAFKAGLVLEPGGFVALEIGYNQGEAVSSLFAAQGFRDIGLIRDGQGHDRVVTAVWPGGKER
>NC_010337.2|WP_012282018.1|900218_901487_-|threonylcarbamoyl-AMP-synthase
MARDFKDTKIWRVDPRQVSAEGLREAAACLQAGGLVAFPTETVYGLGADALQAEAVAAIFTAKGRPSDNPLIVHIADRDDVARLTVGFPALARRLAERFWPGPLTLVLPASPQIPAVVTAGLATVAVRMPSHPVARALIGEAGTPVAAPSANRSGRPSPTTAAHVWEDLGGRIDGIVDGGDCDLGLESTVVDATGDVAVILRPGGVTREMIEALGLPVRTAFAAERLGEGTGAVAGTDAVAGTDAVAGTDAVAGTDAVAGTNEAAEAFCCDGDVEPGGGAGDFVPPSPGMKYVHYAPRAPLYLLDGGWEGQVEALRRLLSPSAERGDDAGPTGLLISEDTYRRIEPMLQQCGDAGHGEKWVVRLTGSREDLATVARRLFGAIRAFDQTTVARIVAETYPHRGIGSALMNRLEKAAGGRRWPG
>NC_010337.2|WP_012282017.1|899480_900122_-|manganese-efflux-pump
MTYWTLGVLAVGLGADAFSMALGIGMEGVRRRDAFMLGLVVALFHIFMPWFGILAGSALGLVVGRLASFIGAAVLFFLGGRMIYHAWKEKREGPAFPVSVPRRRGNGSGGGAIVGAGAIVGGRLFAPTRWELVVIGAAVSMDALSVGFSLGTVGAQLLPTVLTFGVVAGIMTVAGCRIGQQVSRMLGATAQLAGGLILLGIGIKLLLGSASPG
>NC_010337.2|WP_012282014.1|897930_898470_-|TIGR01440-family-protein
MTGIGAQVTAAATELLQAANLQPTQILVVGCSTSEVIGAAIGTKGSEAVAEEILTALRSVTTPKGVYLAIQCCEHLNRALVVEQEMLQLHRELEEVSVRPVAKAGGSLAARAMAHFSRPVVVEAIRAHAGLDIGETLIGMHLRAVAVPVRLSIRQIGEARLTAARTRPKLIGGERACYR
>NC_010337.2|WP_012282013.1|896596_897838_-|serine-hydroxymethyltransferase
MSEWKHLHQVDPEVAAAMDREKKRQKNNIELIASENFVSEAVMEAAGSVLTNKYAEGYPGKRYYGGCEFVDQVERLAIERAKRLFGAEHANVQPHSGANANMGVYFACLEPGDTVLGMNLAHGGHLTHGSPVNISGKYFRFVAYGVDAHTGRIDYDEVARIARETKPKLIVAGASAYPRVLDFARFRAIADEVGAMLMVDMAHIAGLVAAGLHPSPVPYAEFVTTTTHKTLRGPRGGMILCKQEWAAKVDKAIFPGLQGGPLMHIIAAKAVAFQEAMAPAFTAYQKQIAANAAALAKGLTDRGFQLVSGGTDNHLMLVDLRNKQLTGKEAEKRLDECRITVNKNAIPFDPQSPFVTSGIRIGTPAATSRGMDEAAMDQVAEAIHLCLSDGSEGAMQKAVAIVDALCARFPLYA
>NC_010337.2|WP_012282012.1|895907_896537_-|uracil-phosphoribosyltransferase
MARVVIMDHPLIQHKLSFIRSKNTGSKEFRELVEEVAMLMAYEVTRELPLVETEVETPVAVAKTKVLAGKKLGVVAILRAGLGMINGFVKLIPAAKVGHVGLYRDPKTLEPVEYYCKLPPDVAERDMIVIDPMLATGGSASAALTLLKQKGARHIKLVVLIAAPEGVSRVEQDHPDVDIYAAALDPCLNDHAYIVPGLGDAGDRLFGTK
>NC_010337.2|WP_012282024.1|906039_906531_-|DUF2062-domain-containing-protein
MTAWIRCKRFLRFHYLRLLRLKDQPEPLARGVALGFASGFGPFFGLGLVAAWMAAALLRGNRMAAVITAVLFKWAIPLFITANLAVGSWVWGRPLQEAAGGSLWELRFWKEVGLCFITGSAINGVTAYVVAYFPVLYWANRRRLAKRALQANLEQPARFSVRR
>NC_010337.2|WP_012282025.1|906710_907694_-|class-II-fructose-bisphosphatase
MYRELALEFARVTEAAALASARWMGRGDKHAADDAATEAMRAMFDTVSIDGVVVIGEGEMDEAPMLYIGEKVGAGGDAELDIAVDPLEGTNIVAKGLNGAISVLAAAHRGCLLHAPDMYMDKIAVGPAAVGRIHLDAPVEDNLKNVADALGKKIDELSVVILDRPRHSELISRCRKAGARIQLIPDGDVAPAVATAFPDSGIDIMMGIGGAPEGVIAAAAIRCLGGEMQGRLCPETAEEEARCVSMGLEDPRKILLLEDMVRGDGVIFAATGITDGSLLKGVKYTAQGAVTHTVVIRGRTGTVRFINALHRLDRKPHFGRGRNEAQG
>NC_010337.2|WP_012282026.1|908085_908733_-|fructose-6-phosphate-aldolase
MRFFLDSANIDEIREANRLGVISGVTTNPSLIAKEGRNFREVVQEIAAIVDGPISAEVISTDAEGMIAEARELAKIHPNIVIKIPLCAAGLSATARLAQEGIRTNVTLIFSANQGLLAANAGATYVSPFVGRLDDIGHDGMDVLRELVEIFDIHGIATEIIAASIRHPVHVSAAARAGAPIATVPFKVLMQLVKHPLTDLGIERFLKDWESVKDK
>NC_010337.2|WP_012282027.1|908744_909599_-|class-II-fructose-1,6-bisphosphate-aldolase
MPLVPVSQLLAAAEEGKYAVGAFNCNNMEIVQAIVAAAEAERAPVIIQASQGAIKYAGLEYIVALARLAGETASVPVALHLDHGTSFAQCIQCIRSGFTSVMIDGSKYPLEENIALTNRVLEVARAVGVSVEAELGKIGGTEDDIHVDERDAFFTDPAEAKQFVDATKVDALAVAIGTAHGQYKGRPELDFDRLAKIRQLVNIPIVLHGSSGVPEEDIQKAITLGVRKVNIDTNLREAFVDGVKEAIEKNPREIDPRKILGPAKLKMSEVIREKIRIFGSNGKA
>NC_010337.2|WP_012282028.1|909760_910426_-|hypothetical-protein
MILSTMTVVALRCPACGRMDFHALSLFAFAGRKVHKLHCSCGAGLMTVGSKDRRRFWLQAHCIMCETQHLHWFPREQLWSSQLTELRCAETLVEIGFIGPREKVKTAILNQDKSLQEMAENLGLTDFFENPEVMYAVLERLHKLAEEGALSCSCGSFQINVEVYPERVELRCEACDNTYVCYAESDKDLQAMKRCAELQIQGAAPGHRESSRGRRRRKKSP
>NC_010337.2|WP_012282029.1|910485_910872_-|response-regulator
MGDSRWVLVVDDQKGVRRLLYEAFHLVGVPVEVAASGAEALEKLGRREYSLMLLDVRMPAMTGLEALAEARRRGHRLPVILMSAYEDLSLIKEAGALDILDHLIKPFDVMELTQKITRWRASPFEYRS
>NC_010337.2|WP_083765103.1|911181_912084_-|YIP1-family-protein
MEKERAEERAGKVNLPIPSSEMASSESRAIAPSLSGAVEPGAPTGGPICPMVTEHQGEAPPLRRPEEKAGGEQRPHADGEQRAHAGEDERPGRWNCWDYLYHVLVKPKQAFAVAAREKPLGLALSVVLVASVVNLLIDLSLGGAGGPDSPFPPELAGPLLEGLKARIRLFGVLFGLFTWLFMTGFFNLIGELLGGVGNGKGLLASLGLTYWPMLLYAPLGLIGTYAPGGQAVQGLGAFAVTLWIFILQALAIKAALRLSTGRAVFVLLLPLLLLMLALFLFILIALSLLPSLGTLPLSSR
>NC_010337.2|WP_148207163.1|912345_913134_-|signal-peptide-peptidase-SppA
MIADAGAGAGAGLLGGESGSGQVLEALRRLQQDKQIKAVVLRINSPGGTSAASQEIGREVDRLRESGKVVVASMGDVAASGGYWVAARADKIVANAATTTGSIGVILDLANLTELYQKIGYRPNVIKSGPYKDIASSAREMTPEERAILQGMVDDIYQQFIDVVAEGRHMPHEQVRALADGRVFTGRQAKELGLVDELGNFYDAVALAGTMAGIRGEPEIREYGRGSALDRLLSGMTSTGLFGQTLSPVRLLDLLQPKNPLP
>NC_010337.2|WP_049754034.1|913347_914598_-|alanine-racemase
MNGIRPQGADAEDRRGDEAARGLGCWVEVDMDALAHNARSIRQYLGDEKILYGVVKANAYGCGIVECARCLVENGVDRLAVTHVSEGVQLRRSGIDAPILVMAPFMAEETGDLVRFGLTASVSDVDRAVQIAQEARRQGRRGLPVHIKVETGLGRTGVVAAAAPLLVAAIVGQDELYLEGAFTHLATAATGDVRQVHRQVARFLETVAAMEACAGFSIPVKHVANSAAALAFPQYHFDGVRIGTLLYGQPAGPVAAGLALRDVWRLKARVAHVATLPPGHGVGYGRAYVTRRETRVAVLPVGYVDGYQLEPVSVPVSLWDLAKVLVKTSAAYFGLGPTARSVRIGERRAPVLGKVAMQMTMIDVTDIPDVQLGTVVQLPARRTVVALNVPRVHVSAESTMRQRLGSGRREEAARLE
>NC_010337.2|WP_049754224.1|914619_915639_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein
MAEHPKGHVLQSWEWGDVKSRTGWQPHRLMVEEAGTPLAAVSILKRRIPVVGKHIFYAPRGPVIDPARPDAADRLLEGIEALARREKALFLKIDPDVIDPAPDWTEYLCSRGFRRVDKGEGFEGVQPRFVFRLDISDDLDQIFARFHQKTRYNIRLAEKKGVVIDEDCGKEELPLFYKVLKETSERDNFLVRSYAYFEDMWDNLVPAGMAKLFIARYQGEAIAGTLAFILGKKAWYIYGASSNRHRNVMPNYLLQWKMICWAKAEGCTLYDFRGVPGQVGEDHPLYGLVRFKRGFNGDYVGFIGEYDRVYQPFFYHLWNVAEPMYQNLVRKALSRRKGS

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Crispr_ID: NC_010337_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010337_8

1175117-1175217

Orphan

Consensus_repeat	Method
GCGCCGGCATCTGCTGACCGCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010337_8

>merge|NC_010337|8|1175117-1175217|CRISPRCasFinder
GCGCCGGCATCTGCTGACCGCTCTTAAGCCCTGGCGCGGCGACCTTCTCTTTGGTGTAGTCGCAACCACAGCCGTCTAGCGCCGGCATCTGCTGACTGCTC

>NC_010337|8|8|1175117-1175217|CRISPRCasFinder
GCGCCGGCATCTGCTGACCGCTC	TTAAGCCCTGGCGCGGCGACCTTCTCTTTGGTGTAGTCGCAACCACAGCCGTCTA
GCGCCGGCATCTGCTGACTGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_010337.2\|WP_012282263.1\|1180985_1182974_-\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|236848
NC_010337.2\|WP_187147811.1\|1179168_1180866_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NC_010337.2\|WP_148207168.1\|1173586_1174330_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NC_010337.2\|WP_012282250.1\|1167452_1168340_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|349764
NC_010337.2\|WP_041313385.1\|1177766_1178924_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340856
NC_010337.2\|WP_012282270.1\|1187108_1187708_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NC_010337.2\|WP_012282252.1\|1168825_1169188_+\|NifB/NifX-family-molybdenum-iron-cluster-binding-protein	unknown	unknown	gnl\|CDD\|224350
NC_010337.2\|WP_012282268.1\|1186038_1186203_-\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012282272.1\|1188372_1191885_+\|pyruvate:ferredoxin-(flavodoxin)-oxidoreductase	unknown	unknown	gnl\|CDD\|131231
NC_010337.2\|WP_012282266.1\|1183939_1185760_+\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|235505
NC_010337.2\|WP_012282249.1\|1166595_1167456_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|224071
NC_010337.2\|WP_012282257.1\|1174505_1174889_+\|CoA-binding-protein	unknown	unknown	gnl\|CDD\|379152
NC_010337.2\|WP_041314744.1\|1172377_1172812_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NC_010337.2\|WP_012282273.1\|1192382_1193069_+\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012282269.1\|1186781_1187105_+\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NC_010337.2\|WP_041313379.1\|1169220_1169592_+\|NifB/NifX-family-molybdenum-iron-cluster-binding-protein	unknown	unknown	gnl\|CDD\|224350
NC_010337.2\|WP_012282254.1\|1169977_1171828_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374452
NC_010337.2\|WP_049754047.1\|1165984_1166599_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_010337.2\|WP_012282271.1\|1187873_1188146_+\|pro-sigmaK-processing-inhibitor-BofA-family-protein	unknown	unknown	gnl\|CDD\|377835
NC_010337.2\|WP_012282251.1\|1168452_1168782_+\|DUF5320-domain-containing-protein	unknown	unknown	gnl\|CDD\|379955

Protein	Function_ID	Function_description	E-value
NC_010337.2\|WP_012282263.1\|1180985_1182974_-\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|236848	PRK11107, PRK11107, hybrid sensory histidine kinase BarA; Provisional.	1.16198e-86
NC_010337.2\|WP_187147811.1\|1179168_1180866_+\|HD-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	2.29716e-61
NC_010337.2\|WP_148207168.1\|1173586_1174330_+\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	1.91622e-31
NC_010337.2\|WP_012282250.1\|1167452_1168340_+\|ATP-binding-protein	gnl\|CDD\|349764	cd03110, SIMIBI_bact_arch, bacterial and archaeal subfamily of SIMIBI. Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.	4.59098e-98
NC_010337.2\|WP_041313385.1\|1177766_1178924_+\|glycosyltransferase	gnl\|CDD\|340856	cd04950, GT4_TuaH-like, teichuronic acid biosynthesis glycosyltransferase TuaH and similar proteins. Members of this family may function in teichuronic acid biosynthesis/cell wall biogenesis. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	2.94471e-43
NC_010337.2\|WP_012282252.1\|1168825_1169188_+\|NifB/NifX-family-molybdenum-iron-cluster-binding-protein	gnl\|CDD\|224350	COG1433, COG1433, Uncharacterized conserved protein [Function unknown].	7.82501e-22
NC_010337.2\|WP_012282270.1\|1187108_1187708_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	1.83809e-122
NC_010337.2\|WP_012282272.1\|1188372_1191885_+\|pyruvate:ferredoxin-(flavodoxin)-oxidoreductase	gnl\|CDD\|131231	TIGR02176, pyruvate_flavodoxin/ferrodoxin_oxidoreductase, pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric. This model represents a single chain form of pyruvate:ferredoxin (or flavodoxin) oxidoreductase. This enzyme may transfer electrons to nitrogenase in nitrogen-fixing species. Portions of this protein are homologous to gamma subunit of the four subunit pyruvate:ferredoxin (flavodoxin) oxidoreductase.	0
NC_010337.2\|WP_012282266.1\|1183939_1185760_+\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	0
NC_010337.2\|WP_012282249.1\|1166595_1167456_+\|ATP-binding-protein	gnl\|CDD\|224071	COG1149, COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion].	1.58112e-91
NC_010337.2\|WP_012282257.1\|1174505_1174889_+\|CoA-binding-protein	gnl\|CDD\|379152	pfam13380, CoA_binding_2, CoA binding domain. This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.	4.29187e-35
NC_010337.2\|WP_041314744.1\|1172377_1172812_+\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	2.08498e-63
NC_010337.2\|WP_012282269.1\|1186781_1187105_+\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	1.88944e-41
NC_010337.2\|WP_041313379.1\|1169220_1169592_+\|NifB/NifX-family-molybdenum-iron-cluster-binding-protein	gnl\|CDD\|224350	COG1433, COG1433, Uncharacterized conserved protein [Function unknown].	1.70206e-24
NC_010337.2\|WP_012282254.1\|1169977_1171828_+\|hypothetical-protein	gnl\|CDD\|374452	pfam16244, DUF4901, Domain of unknown function (DUF4901). This family consists of uncharacterized proteins around 470 residues in length and is mainly found in various Bacillus subtilis species. The function of this family is unknown.	0.00673361
NC_010337.2\|WP_049754047.1\|1165984_1166599_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.02292e-22
NC_010337.2\|WP_012282271.1\|1187873_1188146_+\|pro-sigmaK-processing-inhibitor-BofA-family-protein	gnl\|CDD\|377835	pfam07441, BofA, SigmaK-factor processing regulatory protein BofA. This family contains the sigmaK-factor processing regulatory protein BofA (Bypass-of-forespore protein A) (approximately 80 residues long). During sporulation in Bacillus subtilis, transcription is controlled in the developing sporangium by a cascade of sporulation-specific transcription factors (sigma factors). Following engulfment, processing of sigmaK is inhibited by BofA. It has been suggested that this effect is exerted by alteration of the level of the SpoIVFA protein.	1.13811e-10
NC_010337.2\|WP_012282251.1\|1168452_1168782_+\|DUF5320-domain-containing-protein	gnl\|CDD\|379955	pfam17253, DUF5320, Family of unknown function (DUF5320). A number of this family members have a coiled coil domain at the C terminal.	0.009731

>NC_010337.2|WP_012282257.1|1174505_1174889_+|CoA-binding-protein
MEDLISSMLKQKVWVVAGSFRSEEKWAYKIYRKLKQKGYTVYALNKAVKEVDGDPTYPELKDLPQVPQVINLVTPPEVSRKLVDESKAVGIDYVWFQPGAESAEAIEAAEKAGLKVLHNACVYALHN
>NC_010337.2|WP_148207168.1|1173586_1174330_+|Fic-family-protein
MEALSRKFREEWTYHTNALEGNTMTLQETVFFLREGLTVEGRTLKEHMEMLNHVEAIDFMQEALSSRDLSERMVKDFHAILFSDMKYAKGEIPVPPGLYKTRDNYVVTLSGEIHHYCPHYLVPEKMEELFRWYEDAKKSLHPLEISALMHQKLVAIHPFPDGNGRTARLVMNFLLLQKGYPPAIIPKERRREYYVALEEGDQGNTERFIRLVAEEVKRSLLVMHTEIAKVVQQQQPITGDKKKTDRV
>NC_010337.2|WP_041314744.1|1172377_1172812_+|nucleoside-deaminase
MGLALEEGRQAYAKGEVPIGCVIVKDGEVIGRGHNLRETEKNPVAHAEVLAIQDAANRIGGWRLAGATLYVTVEPCPMCAGAIVLARIPRVVFAVMDPKGGAAGTCFNILESPWTNHRVSVISGVREGEARELMQSFFQRLRRK
>NC_010337.2|WP_012282254.1|1169977_1171828_+|hypothetical-protein
MIYLKKGCQRKGGRRPAQAALAGLVLASMLAGAFPATALAAASSQTATVGEEANKIEKASPQVEARIQKTIDLLRSLYPEFGSLNLQMKFREKNTRMMHGQRLEREEWILFFDDRQSKDKKSEDWIYNQVHMNFDETGALISYSWQNPNWAGTDMPDKAMASKKAKEFLQKLIGADLDRYASGSASSTGTHGAASDGGKKVTWTHRSVQFEGLVNGIPLMNSSDNWTVDVDGKGRIVGVHHWNKERPDPALYPDPAKAITLEAAKRRLAEQTRMVLSYQPQEFLNQHPGGFADMPLPGRKPMVLVYMPDSMGYIDAFTGNLSEGFNAAADGFKKMEATIRITGQGKERYVRSPEEGRRFIEKDLGFDMTGMTFFDALKGEEEEPAAPTIKRYHWDEQARMDSLIAKIRPDKFRPRYASLTTESDTGRVCGFSIGRVYVDSERQVQEAKQYGAIPAEEAKKKAVSFLQSFLPARTIEMKLLEPKDGQPTYPDWVDLSKLPQDFHESPVYDFIFIPIHDGVPVEGLHWHVSVDKATGTVWSFTYFPVDFDKLPSKRGLLSPEAAKERYLKNLDMKEVYLWPEFFNQRAPKPQLVYMPAYETAGVIDAKTGKPIPFVKE
>NC_010337.2|WP_041313379.1|1169220_1169592_+|NifB/NifX-family-molybdenum-iron-cluster-binding-protein
MSNVRLAIPSVRPGGLSAECSGHFGRCDCFTIVEINDGKRVKDTVIDNPPHYEGGCLRPVNLLSEHQVNALVVQGIGAWPLSGFRQAGIEVYQANEPTVQKVVDAFCAGKISPIDDRQVCQHH
>NC_010337.2|WP_012282252.1|1168825_1169188_+|NifB/NifX-family-molybdenum-iron-cluster-binding-protein
MKVLITSTGPSLDDQVDERFGRARWLLLVDTDSRTLLEALDNHRQVNAMQGSGIKVAEIAGEKGAEWVLTGFVGPKAFAALQAMDIRIGQGVKGTARQVVESFLRGDFTAAEAPNAESHW
>NC_010337.2|WP_012282251.1|1168452_1168782_+|DUF5320-domain-containing-protein
MPRMDGTGPLGKGSMTGRGRGRCILPVGEVPVYQDGALGGQGGARSASGGQGGLRRIANAFCRFGGLGRGRGNGCPANGGLSNRGMGNGGGGFGRRGGGRGANGRNVGF
>NC_010337.2|WP_012282250.1|1167452_1168340_+|ATP-binding-protein
MKQIAVLSGKGGTGKTSLVAAFAALAERSVFADCDVDAADLHLLLQPEIEEKEPFESGRSLTWNKDGCIFCGRCLKVCRFDAIKFDRSGPKQVISPFACEGCGCCVDVCPGEAFTLTPKQAGELYVSTTRFGPFVHAQLGVAEEASGQLVTKVRKRAREIAEQQGMSYVLIDGCPGTGCPVIASITGTDLVVLVTEPTVSGLHDLRRVAQVVRHFRRPCGVVVNKADLNRDMTARIKDECRDEAIPFFGEIPFDDQVVAAQLAGRSIVEQGPSPAGEAIRAIWATISKTVSDSAT
>NC_010337.2|WP_012282249.1|1166595_1167456_+|ATP-binding-protein
MKPIIAIASGKGGTGKTTVAVNLAAVADEPVLLADCDVEEPNCHLFIHPEKKVTTPFSVLMPAFNLEKCVGCGRCRDVCRFQALIMVKGKPMLFPENCHACGGCSRHCPSRAITEVERPVGTIHQGDAGTVRLVYGILDIGEAKSPPLIRAVRRRLNDRTTTGERTVIIDAPPGTSCPVVSAIDGVDYLVLVTESTPFGLHDLQLAVAMARTMGLSFGVIINRAGLGDSRVHDYCQREGITLLMELPFDREVAQVYADGKLPARELPAIREAFQGLWQRLREEVTP
>NC_010337.2|WP_049754047.1|1165984_1166599_+|PadR-family-transcriptional-regulator
MFIGSQGHGSGPGPAPGLGEGSGRGQGPGPGRGPGRGRGRCRCGGMGGGRSDSLVFPGVLLSLRQRPAHGYELMEKLEQMHFVSALPDPAVIYRYLRRLEEEGMVESRLEPGQGGPARKVYSLTAEGESYLQAWVIRIGKQKNDLEAFLQAAERAAGAPGSAGGESAAPSAGESAAKGTSESGGGDADRRSTGQADGGSAGDSQ
>NC_010337.2|WP_041313385.1|1177766_1178924_+|glycosyltransferase
MRIKNIIVLGMYPYPWHEKTISDTMRSMTRAFKGKKRIFINPSVGFQRAVRENYSFAMDWACRDDSGVIVCTPPLETIPSSFGLGSMKNSWVNKRLASLMASLLGDDWREDSLLYLSSGGIGQSYQTMMALKPKRMAFDILDDNLGFPGIRPDEKAVLEDRFRELVNKANVVTAVSPYLVEKFSAKFQNDIHLLPNGLDVERFSYRPEYARPIAELNGLERPVIGFIGALTSWIDFELILKMAEHIKTGSIALVGPIYSTAVSQLKGHPRIRFIDSIPYERVPHFLYQFDILLLPRNYEPHSLASDPLKLYEYMATGKPVLSTALPSAMRFQDVIYVGKTHQDILDLLGKIPAHWSSEQSLAEIQRVASMDWHQRAERLLRWIED
>NC_010337.2|WP_187147811.1|1179168_1180866_+|HD-domain-containing-protein
MRTERAQLEEALRNEALAGATLLASAVGSELQKGDVERINSLAWALLNQPNIQYVRVLDANGRVVTQREKTFYVTDVLIEQVPVLELDKTLGTVEIAVRMTDLRKQQKKRFDYSVAVACLASLAAVAFSAWISRRLTLPLVRLREAARRMADGDRSVRVPEAGSEETVALAIAFNQMAAAVADHQALLQEEIRKATASLAEKVETLESLDRIFRSALAQNARRDEVIGTIIDHIRVRVPAEAISIAVWEEEKKIAECYIWESQGAGILSLSIPLDQTRLLAVAAAGQPRICADLRREAMGLQEEELLALGYHSTVYVPLMAGERALGAIIVSSREPGFYTDEMVGRLTEMAQAVSISLNNANAYTSLNNAFWQMIKTLSRAIDMRDAYTGGHSEQVMLLSRAIARLAGLPDGEIETIGIAGLLHDVGKIGIRESILQKPGPLSADEAAEMKSHPAMGAELLRPIRMFRKVADIVHHHHERFDGKGYPLGLRGEEIPIASRVIAIADAIDAMASDRPYRKGLPPSVIQEELRRHAGTQFDPHLATIVVEHFDELMALVLRTADATV
>NC_010337.2|WP_012282263.1|1180985_1182974_-|hybrid-sensor-histidine-kinase/response-regulator
MVRLDNPEQWKKTIIGYSTLGILAIGILIALVSIIPYYNHLQSDAEQQLIAALRSRTMVLEQFLSKCRDVTLQVTSRSQIKKSLSAYYHGEISRQELALYTAERLKEALNPEAGVIGITRFDRDKQALVQVGAALPQECPCVAEDNSGREAIHGPALIEGTPVLLVSAPITTATGDVLGYDTVIFRTDGLRHILEDKTGLGDTGGVLLARVQGEQGEWLFNLHEASTPSTFPIDTKDPVGATLLKASEGQSGLYNPHFVLAPHHIIAYGPIPDTCWVLLVMMSSDKFYAPIRVQTSLLAGVILGLIVLGVLAITLLLRLLTGKIIIHASEMEAEIRRKTLALEKELQERRQMQTALQLAKEEADVANRAKSAFLANMSHEIRTPMNAIIGIADLLWETPLNEEQKKFVHIFRDAGNNLLALINDILDLSKIESGKQVLQPVEFYLDNLVNDTIALFSTRAQEKGLELTVRLPDDIPRLLLGDVGALRQVLFNLLGNAIKFTETGAVSLHIEVADPVVSPSGATADPNPPHFPGQPVHLRFSVIDTGLGIPPEWQDRIFDSFTQVDASLTRRFGGTGLGLAICKRLVELMGGQIWVDSEPGKGSTFTFTACMVALPPPHLPPAVSVENRLPESAGSSEQAPEPDGRHRRETGAALPPTATKSR
>NC_010337.2|WP_012282266.1|1183939_1185760_+|DNA-polymerase-III-subunit-gamma/tau
MAYLALYREWRPQSFQELVGQEHVSRTLQNAIAYQRIAHAYLFCGPRGTGKTTTAKILAKALNCSGHGPVRPCNDCLNCRAINTGASHDVLEIDAASNRGVDEIRELREQVKYAPQEGNYKVYIIDEVHMLTTEAFNALLKTLEEPPANVIFVLATTEVHKIPATILSRCQRFDFRRLGVNEIVDRLERICRHHEIAASRETLSFIARKAEGGMRDALGILDQCVSYAGNEIDSGDVTAILGAVADEILYDMTQGLAEDRLSDVLMQLNDLINRGKEVRPLTRDLLGHYRDRLILRTVPGAADLVDMPDDIAAKVKETGHVYSVSDLQACIALLSQAENDMKWTTHPRILLEVAFVRIACREWGKGAGNAPASPTSGGAGGAADMEMRALRRRVESLEAKVREMQQAVENQGAASGEKRPSLDSEALRRPQPAMPSATISKLDEETKAAARLAEGPIHIDQVNACWPNVLAAALERISPLKRSILRGQTRLAGVELNRVVLVHNNTLYDQPNDPKLSDVVNALKEEFSKALGRPVSIQLCHESQWKPGGERQQRQRGGAPPAPAKAAGTGGATPPWADPAYIRDKVFQDPNLPVEFDDDDRLDGLE
>NC_010337.2|WP_012282268.1|1186038_1186203_-|hypothetical-protein
MSSREGVKNVPDAKNPELELKEGLNPDDFEETPNTARVRTEMIVGEKGEERTPS
>NC_010337.2|WP_012282269.1|1186781_1187105_+|YbaB/EbfC-family-nucleoid-associated-protein
MFGKMGDMQKMMKQVQKMQQDMVKLQEELVERTVDATGGGGAVKVVANGKNEILSITIAPEAVDPDDVEMLQDLILTVVNEALRKAREMVSQEMSKVTGGLKIPGMF
>NC_010337.2|WP_012282270.1|1187108_1187708_+|recombination-protein-RecR
MRYYAEPVGRLIEELSKLPGVGPKTAQRLAFHLLHVPRNEAVALAKAIVEAHDKTLYCSVCTNLTDRDPCRICSDANRDRAVICVVEEPRDVVAVEKTREYRGHYHVLHGALSPIEGVGPEQLRISQLMARLADPELKEVIVATNPTVEGEATAAYLARLIKPMGVKVTRIAHGLPVGGDLEYADQVTLLRAMEGRREL
>NC_010337.2|WP_012282271.1|1187873_1188146_+|pro-sigmaK-processing-inhibitor-BofA-family-protein
MNLTTEQVVLIGAGVLLLMVTGHLFLRPMRWLFTLAFNSLLGVLLLGGTNLLGAPFGLTLPLNPASALIAGFLGIPGMVLLIMLKYFMIS
>NC_010337.2|WP_012282272.1|1188372_1191885_+|pyruvate:ferredoxin-(flavodoxin)-oxidoreductase
MSKVMQTMDGNKAAAYVSYAFTECAAIYPITPSSTMAEYVDEWSAQGKKNIFGQTVTVAEMQSEAGAAGAVHGALTAGSLTTTYTASQGLLLMIPNMYKISGELLPGVMHVSARAVAGHALSIFGDHSDVMACRQTGWAMLASGSVQEVMDLGGIAHLAAIKSRVPFLHFFDGFRTSHEMQKIEIIDYADFAKLVDYEAVRAFRKRGLNPEHPSVRGTAQNPDIFFQAKEACNPYYKGVADIVAGYMKEIGKLTGRDYLPFNYYGAPDAERIIVAMGSVCDTIEETIDYLLARGEKVGLIKVRLYKPFSAKYFFDVLPATVQKIAVLDRCKEPGSLGEPLYEDVRTLFYDAACQPLIVGGRYGLGSKEVLPSDIKAVFDNLKADEPKNGFTIGIVDDVTFLSLPTGSFIDTAPEGTIQCKFWGLGSDGTVGANKQAVEIIGDHTDMYAQAYFAYDSKKSGGVTVSHLRFGHKPIKSPYLIHKADFISCSNQSYVYNYDLLAGLKEGGVFLLNTVWSPEELEEKLPARIKRTIAEKRIRFYTIDAVHIAKKLGLGNRTNMVMQSAFFKLANVIPIEEAVQYLKEGIKKAYGKKGESVVAMNAAAVDQGIEALVKIDVPASWAEAVDEAAATMEVPAFIEKILQPMNALQGDKLPVSAFADAADGTFPVETSRYEKRGVAAFVPEWIKENCIQCNQCSFVCPHAAIRPFLLNAEEQAKAPATFETIKAIGGKQFEGLTYRLQVTPLDCQGCGVCVMTCPAKQKALTMKELDSQVAVQQPNWDFATTLTIKDNLLKLDSIKGSQFAQPLLEFSGACAGCGETPYVKLITQLFGDRMIIANATGCSSIWGASAPSVPYCTNKEGKGPAWANSLFEDNAEFGYGMHLGVSKIRAKLADLVREALTQDIDAALKAAFNEWLVGMDDAEASKQATAKILPLLEGQTHPLLAEIADRKDYLIKKSQWIFGGDGWAYDIGFGGLDHVLASGEDVNILVMDTEVYSNTGGQSSKATPLSAIAKFASAGKRTKKKDLGLMAMSYGYVYVAQIAMGADMNQTIRAIKEAEAYKGPSLIIAYASCINHGLKSGMANSQIEMARAVKSGYWHLYRFNPELKEEGKNPFILESKEPSESFRDFIMSEVRFNALCRSYPEQAELLFSKMEQDAKERYEMYKRLASF
>NC_010337.2|WP_012282273.1|1192382_1193069_+|hypothetical-protein
MTISGTERQRVVEAYVGEYASGKSENAVNRALELLTQGRQPVTIVDLDIVEPFYTLRPIKKELEEKGLQVVAWETRATMGLGEAGTLIRGDMLWSLRREGDLVLDIGYGVEGSKTLNLLHGAHEDQDLRIIAVINASRPMTSSVEEIVDHVRGLGPVHGLLNNTHLAEETDLAIIREGARLVDGAARELDLPVVANAADERFQGKLTPEDVLGHPVRFLQRFMPRSFW

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Crispr_ID: NC_010337_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010337_9

1832975-1833072

Orphan

Consensus_repeat	Method
TGCGCCCGAGCCTAGCGCTCCCCCTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010337_9

>merge|NC_010337|9|1832975-1833072|CRISPRCasFinder
TGCGCCCGAGCCTAGCGCTCCCCCTTGTGACAATTCTACCTCTGCGAGCACCTTATTTACTGTCAACCCTGCTGCGCCCGAGCCTGGCGCTCCCCCTT

>NC_010337|9|9|1832975-1833072|CRISPRCasFinder
TGCGCCCGAGCCTAGCGCTCCCCCTT	GTGACAATTCTACCTCTGCGAGCACCTTATTTACTGTCAACCCTGC
TGCGCCCGAGCCTGGCGCTCCCCCTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_010337.2\|WP_012282900.1\|1837437_1837638_+\|aspartyl-phosphate-phosphatase-Spo0E-family-protein	unknown	unknown	gnl\|CDD\|378175
NC_010337.2\|WP_012282892.1\|1830148_1830697_+\|epoxyqueuosine-reductase-QueH	unknown	unknown	gnl\|CDD\|376894
NC_010337.2\|WP_012282903.1\|1839723_1840602_+\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
NC_010337.2\|WP_012282891.1\|1829026_1830139_+\|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl\|CDD\|234619
NC_010337.2\|WP_012282889.1\|1827702_1828191_+\|crossover-junction-endodeoxyribonuclease-RuvC	unknown	unknown	gnl\|CDD\|234587
NC_010337.2\|WP_041313602.1\|1835797_1836928_+\|tRNA-guanosine(34)-transglycosylase-Tgt	unknown	unknown	gnl\|CDD\|234642
NC_010337.2\|WP_041313599.1\|1833253_1834672_+\|SpoIID/LytB-domain-containing-protein	unknown	unknown	gnl\|CDD\|274252
NC_010337.2\|WP_041313596.1\|1827090_1827675_+\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012282901.1\|1837707_1838364_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225831
NC_010337.2\|WP_012282890.1\|1828187_1829012_+\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NC_010337.2\|WP_148207177.1\|1830991_1831741_+\|RNA-polymerase-sigma-factor-SigI	unknown	unknown	gnl\|CDD\|236233
NC_010337.2\|WP_012282905.1\|1841997_1844208_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NC_010337.2\|WP_012282885.1\|1825006_1825207_+\|CooT-family-nickel-binding-protein	unknown	unknown	gnl\|CDD\|378406
NC_010337.2\|WP_012282897.1\|1834671_1835706_+\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	unknown	unknown	gnl\|CDD\|234666
NC_010337.2\|WP_012282886.1\|1825211_1825979_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|234640
NC_010337.2\|WP_041313609.1\|1838496_1839705_+\|protein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
NC_010337.2\|WP_148207178.1\|1840846_1841752_+\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131
NC_010337.2\|WP_148207176.1\|1830726_1830918_+\|DUF2905-family-protein	unknown	unknown	gnl\|CDD\|378570
NC_010337.2\|WP_012282887.1\|1826304_1826775_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NC_010337.2\|WP_012282899.1\|1837022_1837289_+\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|376903

Protein	Function_ID	Function_description	E-value
NC_010337.2\|WP_012282900.1\|1837437_1837638_+\|aspartyl-phosphate-phosphatase-Spo0E-family-protein	gnl\|CDD\|378175	pfam09388, SpoOE-like, Spo0E like sporulation regulatory protein. Spore formation is an extreme response to starvation and can also be a component of disease transmission. Sporulation is controlled by an expanded two-component system where starvation signals result in sensor kinase activation and phosphorylation of the master sporulation response regulator Spo0A. Phosphatases such as Spo0E dephosphorylate Spo0A thereby inhibiting sporulation. This is a family of Spo0E-like phosphatases. The structure of a Bacillus anthracis member of this family has revealed an anti-parallel alpha-helical structure.	3.84916e-06
NC_010337.2\|WP_012282892.1\|1830148_1830697_+\|epoxyqueuosine-reductase-QueH	gnl\|CDD\|376894	pfam02677, DUF208, Uncharacterized BCR, COG1636.	2.23754e-81
NC_010337.2\|WP_012282903.1\|1839723_1840602_+\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	5.51277e-123
NC_010337.2\|WP_012282891.1\|1829026_1830139_+\|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl\|CDD\|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NC_010337.2\|WP_012282889.1\|1827702_1828191_+\|crossover-junction-endodeoxyribonuclease-RuvC	gnl\|CDD\|234587	PRK00039, ruvC, Holliday junction resolvase; Reviewed.	4.81694e-92
NC_010337.2\|WP_041313599.1\|1833253_1834672_+\|SpoIID/LytB-domain-containing-protein	gnl\|CDD\|274252	TIGR02669, stage_II_sporulation_protein_D, SpoIID/LytB domain. This model describes a domain found typically in two or three proteins per genome in Cyanobacteria and Firmicutes, and sporadically in other genomes. One member is SpoIID of Bacillus subtilis. Another in B. subtilis is the C-terminal half of LytB, encoded immediately upstream of an amidase, the autolysin LytC, to which its N-terminus is homologous. Gene neighborhoods are not well conserved for members of this family, as many, such as SpoIID, are monocistronic. One early modelling-based study suggests a DNA-binding role for SpoIID, but the function of this domain is unknown. [Unknown function, General].	8.5702e-74
NC_010337.2\|WP_041313602.1\|1835797_1836928_+\|tRNA-guanosine(34)-transglycosylase-Tgt	gnl\|CDD\|234642	PRK00112, tgt, queuine tRNA-ribosyltransferase; Provisional.	0
NC_010337.2\|WP_012282901.1\|1837707_1838364_+\|HD-domain-containing-protein	gnl\|CDD\|225831	COG3294, COG3294, HD supefamily hydrolase [General function prediction only].	1.75091e-09
NC_010337.2\|WP_012282890.1\|1828187_1829012_+\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	5.503e-64
NC_010337.2\|WP_148207177.1\|1830991_1831741_+\|RNA-polymerase-sigma-factor-SigI	gnl\|CDD\|236233	PRK08311, PRK08311, RNA polymerase sigma factor SigI.	1.34349e-106
NC_010337.2\|WP_012282905.1\|1841997_1844208_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NC_010337.2\|WP_012282885.1\|1825006_1825207_+\|CooT-family-nickel-binding-protein	gnl\|CDD\|378406	pfam10133, RNA_bind_2, Predicted RNA-binding protein. Members of this family of bacterial proteins are thought to have RNA-binding properties, however, their exact function has not, as yet, been defined.	4.86286e-21
NC_010337.2\|WP_012282897.1\|1834671_1835706_+\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	gnl\|CDD\|234666	PRK00147, queA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional.	0
NC_010337.2\|WP_012282886.1\|1825211_1825979_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|234640	PRK00110, PRK00110, YebC/PmpR family DNA-binding transcriptional regulator.	1.89128e-153
NC_010337.2\|WP_041313609.1\|1838496_1839705_+\|protein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	7.90503e-169
NC_010337.2\|WP_148207178.1\|1840846_1841752_+\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	3.44789e-91
NC_010337.2\|WP_148207176.1\|1830726_1830918_+\|DUF2905-family-protein	gnl\|CDD\|378570	pfam11146, DUF2905, Protein of unknown function (DUF2905). This is a family of bacterial proteins conserved of unknown function.	1.64876e-13
NC_010337.2\|WP_012282887.1\|1826304_1826775_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	3.58016e-49
NC_010337.2\|WP_012282899.1\|1837022_1837289_+\|preprotein-translocase-subunit-YajC	gnl\|CDD\|376903	pfam02699, YajC, Preprotein translocase subunit. See.	4.46852e-28

>NC_010337.2|WP_148207177.1|1830991_1831741_+|RNA-polymerase-sigma-factor-SigI
MLGSGVFASRNQEPENLLVRAREGDECSRNALIRKFTPFVLRVTSQTSGRYVRLGSDDEASIALIAFNEAITSYQEEKGVSFLSFAETVIRRRLIDYFRKQTRSQKEIPLSAFDYESEDDTGEEGNNRMEIRQATAAYMAESEANDRRNEILYYNKLLQEYGIRFSELVEVAPKHEDARRRAIQVARQVAETPAYREYLRLKGSLPLKELERDVDVSRKTLERQRKYIIAVAIIFMEKLDHLKEYIDKE
>NC_010337.2|WP_148207176.1|1830726_1830918_+|DUF2905-family-protein
MVLGAGLLLLGGLFWLLSQFVSLGRLPGDISWQKGNFSFYFPLASSLLLSLLLTILLNLFLRR
>NC_010337.2|WP_012282892.1|1830148_1830697_+|epoxyqueuosine-reductase-QueH
MRLLLHTCCAPCGIVPFDVLREEGHAVTAYYYNPNIHPYKEFLRRKETLEGYAASINLPLIVEEGYALEDFLRRVAADPAGRCPHCYDLRLRKTAEKARELGMEGFSTTLLISPYQDHETLRRAGEAAGREVGVPFVYADFRASFREGQQRARERELYRQPYCGCIYSEKDRYYKPKGGFKR
>NC_010337.2|WP_012282891.1|1829026_1830139_+|Holliday-junction-branch-migration-DNA-helicase-RuvB
MDERMMTSAKRPEDRETEWSLRPRTLREYIGQDKLKENLTVFIQAALGRREPLDHVLLYGPPGLGKTTLAQIIAQELGVQLRVTSGPAIERPGDLAAILTNLQPMDVLFIDEIHRLNRAVEEVLYPAMEDFCLDIVIGKGPAARSIRIDLPRFTLVGATTRAGMLTSPLRDRFGVIHRLEYYRPDELEFIILRAATILGVTAEPEGAREIALRSRGTPRIANRLLKRVRDYAQVLSDGVVTGEVAREALRRLEVDPRGLDTTDQRLLEALIRKFAGGPVGVETLAASVGESVDTVEDVVEPYLMQLGFLNRTPRGRMATIAACAHLGVPVPAGLLALQEGRPALLPSATDDTSSTAVGAAAEQAALSFDE
>NC_010337.2|WP_012282890.1|1828187_1829012_+|Holliday-junction-branch-migration-protein-RuvA
MIAFLRGRLVGLGDDCLLLDVSGVGYRVFVPATMLASLPQVGRDILIHTFYYAREDQVSLYGFLTEEELAFFRLLLEVSGVGPKVGLGILSAYSVVEVQRAIIAEDVLALTRIPGIGRKTAQRLVIELRDKLLKQGVRAVPVFGVDPFLEEASSQEQDQNAQDPLQQEQSPGSPEEQLPEKASLQNHSLKDPSSDRHVPEGTSPLARRRKKAVPAGADRMWKTSPRDEAFSALQVLGYTANEARDALVEAAALVPPDADVEAWIKGALRFLGSQ
>NC_010337.2|WP_012282889.1|1827702_1828191_+|crossover-junction-endodeoxyribonuclease-RuvC
MVILGIDPGTAICGYGLIEVQGNRLSALAYGAVRTPAHTSQASRLQTIFTDLEAIIATYRPTHVAVEELFFNRNVTTALTVGQARGVILLAAARAGLSVHEYKPSQVKQAVVGYGRAEKQQVQQMVRVLLALEEIPKPDDVADALAVAICCAHSLTWGVACR
>NC_010337.2|WP_041313596.1|1827090_1827675_+|hypothetical-protein
MALFMVTFSLTVITVFAYDFMVVKSDGAWANRYGKDMLHQPIAPGVAITIEKTYRLCGHQEIENLERPEDWTGRPFRELLQRYPESAGWRWELRPGQIRLFRSVDGLCPDDAAKRHLGIVGGVVAVIVGPPGLYGGIDRLTDLPAERLPRPLYELAERGWLGGMTPEELSLLLDGMDESDGHKEKDSTEGRRKP
>NC_010337.2|WP_012282887.1|1826304_1826775_-|Lrp/AsnC-family-transcriptional-regulator
MYDAVDCRILQHLQRNGRVTQTELASLVGLSSPAVAERIKKLEEKGVIQGFQARLNPKALDLGLTAFISLRLDHPNSYPQFVEQILGCPYILECHRVTGEDGFLLKIRVKDTVELEQILTTQILSLPGVSHTRTSIALATPKEETVLPLPTEEQSA
>NC_010337.2|WP_012282886.1|1825211_1825979_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MAGHSKWANIKHRKAKVDAQKGKIFTKIGRELIVAARQGGPDPNSNFRLKIAIQKAKENNMPNDNIQRAIQRGAGGTEGANYEELTYEGYGPGGVAIMIEAMTDNRNRTAGEIRHLFSKSGGNLGETGCVSWIFEPKGVIRLAVTPEAGAKVVDEDELMLVALETGALDIAVEEDEAEVFTLPEELEGVRQALADAGYAVLSAEVTLVPKNTMEVTDKDIATKLIKLMDALEEHDDVQNAYANFNIDDAVMEQIG
>NC_010337.2|WP_012282885.1|1825006_1825207_+|CooT-family-nickel-binding-protein
MCEANAYLRRNGKDQLILEAVDKLIPQAGQISMINIFGQQKTLKARIIELALVDHKIILEELQEEL
>NC_010337.2|WP_041313599.1|1833253_1834672_+|SpoIID/LytB-domain-containing-protein
MSGNKRTAWAIFLALFSIFSLSTGLGPAVAADREDRFELRVLLDQRSSVDIRVLSGTYQWYDEDLQTPVETVSPSDGWRAFAAGSTIQLDKNGRSLAKAYGGPLLLQAKGAGENKIEVNGKKYRGSLRLYHLRSQGANGMALINVIDVESYLYGVVGQEIGMNAPEEAMKAQAVVSRTYALQQRERRRQIGDYYDLRADLGSQVYKGVDGEQARVLKAVDDTRGQVITYDGAIIEAVFHSNSGGYTEDARLVWNSDVPYLRGVPAPEDRYAEEWGGTAALAYHWRKQLTPDEIARKTQSLTGKDLGELQRLRIVETSRSGRVTRLEVVGSRGTVSIDRTKVRQLLDTPSTKFTLADGSGNYVALGYGADGIKKNALPAGGTYAITSSGVAAVSSDPYVITSDGVGPAPKAPSTTAAGIIVIDGYGYGHGVGMSQWGAMGLARNGKSYTEIIEHYYNADRRDGRLQITNNWGK
>NC_010337.2|WP_012282897.1|1834671_1835706_+|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA
MEVALYDYELPKEAIAQTPVEPRDASRLMVLERRTGAVDHRIFRDLVHILHPGDLLVVNRTRVIPARLFGKKRDSDVTVEIVLLTPMGDDRWEVLVRPGRRLKPGVFVDLGEGRLAAEIVETTDFGGRVVRFHYSGDFDTLIDEIGQMPLPPYIETALPRQEAERYQTVYSQERGSAAAPTAGLHFTPQLLEDLKKRGIEITSVLLHVGLGTFRPVQVDRIEEHKMHSEFFQVDPEAARAIAKAKQEGRRVIAVGTTVARTLETAAGLHNGTVAAGSGWTDIFIYPGYTFQCIDGLITNFHLPRSTLLMLVSAFAGREQVLAAYREALEKGYRFFSFGDAMLII
>NC_010337.2|WP_041313602.1|1835797_1836928_+|tRNA-guanosine(34)-transglycosylase-Tgt
MHLTAAVRYELIKECTRTSARAGILHTPHGSFETPIFMPVGTQATVKTMTPEEVRELGAGIILSNTYHLYLRPGSDLVREAGGLHKFMNWSHGILTDSGGFQVFSLGPLRKITEEGVRFKSHIDGSEHFFTPEKSIQIQMDLGADIIMAFDECPPYPAEREYAQKSLEMTIRWAKRCRAAHTRKDQALFAITQGGMYADLRKESAARLVELDFPGYGIGGLSVGEPKPLMYEMLDATVPELPKNKARYLMGVGSPDCLWEGVERGVDMFDCVLPTRVARNGLAFTSHGKVVIRNAEHARDFERLDPECSCYTCRHYSRAYLRHLYKAEEILAYRLLTIHNLHMLLNLMRNIRQSILEDRFYEAKKAFFDKYGEERG
>NC_010337.2|WP_012282899.1|1837022_1837289_+|preprotein-translocase-subunit-YajC
MMDSSLLLVYLAAMFGLFYYLFIRPQKKAQKEHKEMLDKLRVHERVLTAAGIYGVITEVGEDTVTVKIAEGVQVDFAKTAILRVVDNN
>NC_010337.2|WP_012282900.1|1837437_1837638_+|aspartyl-phosphate-phosphatase-Spo0E-family-protein
MDSSVLLRRIQRKRKELERLARRFDSRNLTSGVVYRKSCELDRLIVEYMRTNRQLELDFPDFLPGR
>NC_010337.2|WP_012282901.1|1837707_1838364_+|HD-domain-containing-protein
MTVSIQEIRENPEVRAYIEKGDERLAVLGFTEHGLRHSAHVSAQAEAILSHLNYPERIAELAAIAGYMHDIGNAVSRDSHAQIGALLARSILRDMKMDFREIAEVMAAIGNHDETVGQVMNVAGAALILADKSDVHYRRVRNKERVAFDIHDRVNYAVRDSKLVLEGADISLTLTTDPDISPVLDYFEIFLPRMVMCRRAAAFLDCRFHLVINDAKML
>NC_010337.2|WP_041313609.1|1838496_1839705_+|protein-translocase-subunit-SecD
MNARKLLQLVALISVVAIAAALSYNPIVQNTKLGLDLQGGLHVVLQAVETPDRKVTQEEMQQVHAIMEQRINGLGVAEPLIQLEGTNRLIIELAGIQDPDKAVDLIGKTALLTFRTADGQTVIEGKDLKEAKEALEPGSNMAIVHLTLNSEGAKKFADVTRANVGKQIGIYLDEDLLQNPTVSEAITGGQARITGYGSLEDARRIAMLLNSGALPVKMEMVEKRTVGPTLGAESLEKSKAAAMIGVGLIFAFMFLYYRVPGFVAIVSLILYSVIVVGILTLLKATWTLPGIAGFLLSLGVAVDANVIIYERLKEELRAGKTLRTAIEDGFQRAFTTILDSNVTTLISIVILYYLGTGPIRGFAVTLGIGILTSMFTALSFTRMMLRSAGGSGLFNNKKLYGA
>NC_010337.2|WP_012282903.1|1839723_1840602_+|protein-translocase-subunit-SecF
MEIIGRRKIWYALSLLILIPGLISLLLQGLNLGIDFTGGSMLQLKFERAVTVENVRDVLDKANVGSSTIQLAEGNSVIVRTHTLEQSQRNELVGAMKTQLGDLTVERDENVGPVVGKELTRNALLALLLAIIGMVAYISFRFEFKFAVAAIIALLHDILVVTGLFSIFQIEVDSSFVAAILTVFGYSINDTIVIFDRIRENLRKKKKDENLDALVNRSVKETLTRSINTVLTVIFVLVALLFWGGNTTKVFTLAMLLGVIAGAYSSIFNASPVWYDLKQWERAQRRAKAKAA
>NC_010337.2|WP_148207178.1|1840846_1841752_+|cation-diffusion-facilitator-family-transporter
MVDERLRVAKLSVFSNLLLVIGKLAVGWLIGSVSVISEGIHSGLDLVAALIAFFSVREASRPADDSHQFGHGKIENVAGTIEALLIFLAAIWIIYEAVEKLSHGGMAPEAGWGVLIMAISAGVNFYVSSRLMAVARKTDSVALEADALHLRTDVYTSLGVLVGLILLKLTGWWILDPLVAIGVALLIVKASWDLLQEAFMPLLDQRLPEEEESQIQERIQRHAEKYVNVHAIRTRRSGAERHIDMHMVFCKRTSIQETHEISDRVEAEIQEIFPKSTVLVHQEPCDERCGECQFGHKEGRQ
>NC_010337.2|WP_012282905.1|1841997_1844208_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MQVTLGQLLKRVQSYTQNPADLEFVRRAFEYADAAHTGQLRKSGEPYIYHPMAVAYILADLELDVATIAAGLLHDVVEDTAITQEQLEKDFGPEVALMVDGVTKLSRLEFHSKQEQQVESLRKMFLAMAKDIRVILIKLADRLHNMRTLKHQTPEKQREIAIETIELFAPLANRLGISRIKWELEDLALRYLEPETYYDLVTRIATKRAEREERINEIIAILREKLAAVGIKAEISGRPKHFYSIYRKMTSQKKDLSEIYDLIAVRVLVDSVKDCYGALGIIHTIWKPIPMRFKDYIATPKTNMYQSLHTTLVGPLGEPFEVQIRTAEMHRTAEYGIAAHWKYKEGGKTQGRSFEEKLAWLRQLLEWQSDQKDTQTFMETLKIEFFSDAVFVFTPKGDVIELPAGSTPIDFAYRIHSNVGHRCMGAKVNGRIVPLDYRLNNGEIIEILTKTTAGHSRDWLNVVKTSNARNRIRQWFKKEKREEFVERGKEALEAELKRLKLDPADVLKTERMLDISKRFNYQTADDLYFAIGDGVLTVNQIILRLKEELKKEKRLEEDQAPPPEVKPFSGFGKPSQGVRVRGVDNVLIRFSRCCNPLPGDEIIGYITKGRGVSIHRVDCTNVVNMSEEERERIVEVAWDATSQATYQVEIEVIAMDRERLTTDVMLSVADTKTSINSIYSRATKNKMAQINMVVEIRDLGHLKFLMDKVSRVRDVLEVRRLTPNTKAERDGESLLG

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Crispr_ID: NC_010337_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010337_10

1872711-1872805

Orphan

Consensus_repeat	Method
GTTACAGACCGGAGCAAGCTGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010337_10

>merge|NC_010337|10|1872711-1872805|CRISPRCasFinder
GTTACAGACCGGAGCAAGCTGAACCCGGTCTGTGACTGCCGTAGCCTGACATCCCCGCGACGAGCAAATGAGTTACAGACCGAAGCAAGCTGAAC

>NC_010337|10|10|1872711-1872805|CRISPRCasFinder
GTTACAGACCGGAGCAAGCTGAAC	CCGGTCTGTGACTGCCGTAGCCTGACATCCCCGCGACGAGCAAATGA
GTTACAGACCGAAGCAAGCTGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_010337.2\|WP_012282931.1\|1871496_1872594_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NC_010337.2\|WP_012282932.1\|1874756_1875773_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NC_010337.2\|WP_012282937.1\|1880306_1882052_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NC_010337.2\|WP_012282924.1\|1866938_1867391_+\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NC_010337.2\|WP_012282922.1\|1864411_1865116_+\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|377783
NC_010337.2\|WP_012282942.1\|1885401_1888077_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341370
NC_010337.2\|WP_012282921.1\|1862667_1864431_+\|energy-coupling-factor-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NC_010337.2\|WP_012282936.1\|1879474_1880332_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_010337.2\|WP_012282927.1\|1868615_1868993_+\|Fe-S-cluster-assembly-scaffold-protein-NifU	unknown	unknown	gnl\|CDD\|132460
NC_010337.2\|WP_012282926.1\|1867446_1868613_+\|cysteine-desulfurase-NifS	unknown	unknown	gnl\|CDD\|132443
NC_010337.2\|WP_148207179.1\|1876897_1878493_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173885
NC_010337.2\|WP_012282935.1\|1878504_1879485_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_010337.2\|WP_012282939.1\|1883679_1884993_+\|diaminopimelate-decarboxylase	unknown	unknown	gnl\|CDD\|143501
NC_010337.2\|WP_012281187.1\|1872984_1874607_-\|IS1182-like-element-ISHmo2-family-transposase	unknown	unknown	gnl\|CDD\|377531
NC_010337.2\|WP_049754089.1\|1876226_1876883_+\|TraR/DksA-C4-type-zinc-finger-protein	unknown	unknown	gnl\|CDD\|225102
NC_010337.2\|WP_049754240.1\|1869236_1870370_+\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_010337.2\|WP_012282923.1\|1865260_1866757_+\|deoxyribodipyrimidine-photo-lyase	unknown	unknown	gnl\|CDD\|129679
NC_010337.2\|WP_012282930.1\|1871202_1871394_+\|hypothetical-protein	unknown	unknown	unknown
NC_010337.2\|WP_012282929.1\|1870456_1871185_+\|PRC-barrel-domain-containing-protein	unknown	unknown	gnl\|CDD\|368352
NC_010337.2\|WP_012282938.1\|1882323_1883172_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293801

Protein	Function_ID	Function_description	E-value
NC_010337.2\|WP_012282931.1\|1871496_1872594_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	9.17809e-55
NC_010337.2\|WP_012282932.1\|1874756_1875773_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	8.84784e-25
NC_010337.2\|WP_012282937.1\|1880306_1882052_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	0
NC_010337.2\|WP_012282924.1\|1866938_1867391_+\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	1.71274e-56
NC_010337.2\|WP_012282922.1\|1864411_1865116_+\|ECF-transporter-S-component	gnl\|CDD\|377783	pfam07155, ECF-ribofla_trS, ECF-type riboflavin transporter, S component. This family is the substrate-binding component (S component) of the energy coupling-factor (ECF)-type riboflavin transporter. It is a transmembrane protein which binds riboflavin, and is responsible for riboflavin-uptake by cells.	2.88966e-05
NC_010337.2\|WP_012282942.1\|1885401_1888077_+\|CBS-domain-containing-protein	gnl\|CDD\|341370	cd04595, CBS_pair_DHH_polyA_Pol_assoc, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the DHH and nucleotidyltransferase (NT) domains. This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream nucleotidyltransferase (NT) domain of family X DNA polymerases. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	1.60286e-64
NC_010337.2\|WP_012282921.1\|1862667_1864431_+\|energy-coupling-factor-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	6.44426e-85
NC_010337.2\|WP_012282927.1\|1868615_1868993_+\|Fe-S-cluster-assembly-scaffold-protein-NifU	gnl\|CDD\|132460	TIGR03419, NifU_clost, FeS cluster assembly scaffold protein NifU, Clostridium type. NifU and NifS form a pair of iron-sulfur (FeS) cluster biosynthesis proteins much simpler than the ISC and SUF systems. Members of this protein family are a distinct group of NifU-like proteins, found always to a NifS-like protein and restricted to species that lack a SUF system. Typically, NIF systems service a smaller number of FeS-containing proteins than do ISC or SUF. Members of this particular branch typically are found, almost half the time, near the mnmA gene, involved in the carboxymethylaminomethyl modification of U34 in some tRNAs (see GenProp0704). While other NifU proteins are associated with nitrogen fixation, this family is not. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	7.95558e-81
NC_010337.2\|WP_012282926.1\|1867446_1868613_+\|cysteine-desulfurase-NifS	gnl\|CDD\|132443	TIGR03402, Cysteine_desulfurase_NifS, cysteine desulfurase NifS. Members of this protein family are NifS, one of several related families of cysteine desulfurase involved in iron-sulfur (FeS) cluster biosynthesis. NifS is part of the NIF system, usually associated with other nif genes involved in nitrogenase expression and nitrogen fixation. The protein family is given a fairly broad interpretation here. It includes a clade nearly always found in extended nitrogen fixation genomic regions, plus a second clade more closely related to the first than to IscS and also part of NifS-like/NifU-like systems. This model does not extend to a more distantly clade found in the epsilon proteobacteria such as Helicobacter pylori, also named NifS in the literature, built instead in TIGR03403.	0
NC_010337.2\|WP_148207179.1\|1876897_1878493_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173885	cd08520, PBP2_NikA_DppA_OppA_like_21, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NC_010337.2\|WP_012282935.1\|1878504_1879485_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.62664e-102
NC_010337.2\|WP_012282939.1\|1883679_1884993_+\|diaminopimelate-decarboxylase	gnl\|CDD\|143501	cd06828, PLPDE_III_DapDC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase. Diaminopimelate decarboxylase (DapDC, EC 4.1.1.20) participates in the last step of lysine biosynthesis. It converts meso-2,6-diaminoheptanedioate to L-lysine. It is a fold type III PLP-dependent enzyme that contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. DapDC exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity.	2.2508e-177
NC_010337.2\|WP_012281187.1\|1872984_1874607_-\|IS1182-like-element-ISHmo2-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.30853e-11
NC_010337.2\|WP_049754089.1\|1876226_1876883_+\|TraR/DksA-C4-type-zinc-finger-protein	gnl\|CDD\|225102	COG2191, COG2191, Formylmethanofuran dehydrogenase subunit E [Energy production and conversion].	5.65854e-61
NC_010337.2\|WP_049754240.1\|1869236_1870370_+\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_010337.2\|WP_012282923.1\|1865260_1866757_+\|deoxyribodipyrimidine-photo-lyase	gnl\|CDD\|129679	TIGR00591, Deoxyribodipyrimidine_photo-lyase, photolyase PhrII. All proteins in this family for which functions are known are DNA-photolyases used for the direct repair of UV irradiation induced DNA damage. Some repair 6-4 photoproducts while others repair cyclobutane pyrimidine dimers. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	1.68518e-118
NC_010337.2\|WP_012282936.1\|1879474_1880332_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.09216e-67
NC_010337.2\|WP_012282929.1\|1870456_1871185_+\|PRC-barrel-domain-containing-protein	gnl\|CDD\|368352	pfam05239, PRC, PRC-barrel domain. The PRC-barrel is an all beta barrel domain found in photosystem reaction centre subunit H of the purple bacteria and RNA metabolism proteins of the RimM group. PRC-barrels are approximately 80 residues long, and found widely represented in bacteria, archaea and plants. This domain is also present at the carboxyl terminus of the pan-bacterial protein RimM, which is involved in ribosomal maturation and processing of 16S rRNA. A family of small proteins conserved in all known euryarchaea are composed entirely of a single stand-alone copy of the domain.	9.79656e-09
NC_010337.2\|WP_012282938.1\|1882323_1883172_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293801	cd07715, TaR3-like_MBL-fold, MBL-fold metallo-hydrolase domain of Myxococcus xanthus TaR3 and related proteins; MBL-fold metallo-hydrolase domain. Myxococcus xanthus Tar3 may function as an ammonium regulator/effector protein involved in biosynthesis of the antibiotic TA. Some are members of this subgroup are annotated as ribonucleases. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	6.61309e-107

>NC_010337.2|WP_012282931.1|1871496_1872594_+|AI-2E-family-transporter
MEGKARVIGGLFGFSGEKHVEVETALPKGRWRILLVAGFWAIVLLLSYLLRQTLVPFAVAFVLAYLLYPGVVWLEKGGLSRVVSILAVFAVVFGGFASLIAFGMPRIFSELNRFSVQLPQYTQQMQAWLARIQQDMIQSGFPPGIQQVWSDTLARGEATILAAVRWLLESAVSLAENAFDIVLIPVMSFYFLRDWEAIGKGSLNLVPQNLRAHVQIVGGEVNRILRAVVRCNFLMALVVGVLTTVGLTLIGLEYSLLIGIIAGIADLIPYFGPLIGMVPALVVGLLESPRLALYAVLIMIVVQQIEANLLSPKLLGDSVGLHPLAVIFALLAGGHLFGIVGLLLAVPVVAVGKVVGRYVLLKVLV
>NC_010337.2|WP_012282930.1|1871202_1871394_+|hypothetical-protein
MSCPVCGGKQVGKVGVNQFYCWNCFIEFNERNEIFEVAEDGSLMALEPDPPLMDLDGANAAPV
>NC_010337.2|WP_012282929.1|1870456_1871185_+|PRC-barrel-domain-containing-protein
MRKGRDIIHLPVVHSATGKTVGRVTDLIVNTREGRVTGLLLAAEGESANRRIDWTQVIYDRDVIRTEAEPAPHDPASLEPKPHDRAGHDSASHESAGHALAMQEPAGHAPDDQAPLSNVPAAYDLVNHEPPTDDQVRHEQAPCEPAHEQASPGEPSPATPVLLCLSRCEGHPVRTQAGRPLGQVGDILFDPAQGQLTAVEVSDGLMQDLLTGRLQLPWPDVTEWRADTVIVADHWQDAWQRE
>NC_010337.2|WP_049754240.1|1869236_1870370_+|tRNA-2-thiouridine(34)-synthase-MnmA
MSGGVDSSVTAALLLEQGYDVIGVTLQIWPKDAPEGAEGGCCSLSAVEDAKRVASKLGVPHYVLNFRDYFETEVIEYFGREYLAGQTPNPCIRCNRVIKFEGLLQKSLALGAAKVATGHYARIEQDSATGRYRLGRGIDANKDQSYALFNMTQEQLSRTLFPLGGFTKPEIREKAAQLGLAVASKPDSQEICFIPDNDYRRFLEERYPDHRFQPGPFVDQEGNVIGTHRGLPFYTVGQRKGLGVAFGFPAYVIALDVEHNAVVIGPDEAVKGRRLLADDLNWIDIAGLKAPMEVEAKIRYSASPAIAVISPVKDGSAVIVEFAAPQRAITPGQAVVFYRGDWVVGGGTIVRNLDLKLPEIRHPEPKPVKGVKAKGRV
>NC_010337.2|WP_012282927.1|1868615_1868993_+|Fe-S-cluster-assembly-scaffold-protein-NifU
MYTDKVMDHFMNPRNVGEIENASGVGEVGNASCGDIMRIYLDVEDNIIKDVKFKTFGCGAAIATSSMVTELIKGKTIDEALGLTNRAVADALGGLPPQKMHCSNLAADALHKAIADYKAKQEAKR
>NC_010337.2|WP_012282926.1|1867446_1868613_+|cysteine-desulfurase-NifS
MRRVYLDHGATTPVHPAVIEAMVDCMQNHFGNPSSVHSFGREAKKLLEEARAKVAHLIGARPEEIIFTSGGTEADNLTIFGVARAMRKKGNHVITSAAEHHAVLDACQALTKEGFEVTVLPVDKYGMVRVEDVKAALKPETVLVTIMHANNEVGTINPIKEITQLVKAHGAVMHTDAVQTVGKIPVDVNDLGVDLLSLSSHKIYGPKGVGALYIRKGTKLFPLSHGGGQERKRRPGTENLPGIVGFGKAAEIMARELPEEMGRMGRLRQRLIEGLLAIPEVQLNGHPTERIPINVNVSIKYIEGESLLLMLDMKGIAASSGSACTSGSLDPSHVLLAMGICHEVAHGSLRLTLGRDNTEEDIEYVLDVLPPIVERLRAMSPLYANKEG
>NC_010337.2|WP_012282924.1|1866938_1867391_+|Rrf2-family-transcriptional-regulator
MKLSTKGQYGVRAMFELAMQYGQGPVSLKLVAERQDISEHYLEQIIAGLRKAGLVNSIRGAQGGYVLARDPAEITVGDIIRVLEGPVAPVDCVNDDIPERCTRASQCISKRVWAKVRDSIEQVIDSITLADMCKDAEKMKYDEGAFMYHI
>NC_010337.2|WP_012282923.1|1865260_1866757_+|deoxyribodipyrimidine-photo-lyase
MIQRERIQVLNAGSAQAGRYVLYWMQASQRAEYNHALEYAIGEANKLGLPVLVFFGLTGGVPGANARHYRFLLEGLCDVREALQRRGIAMIIRRIPPVEGVVALARRAALVVTDRGYLRYQRQWREAAAARIDCPFIQVESDVIVPVETASPKEEYGAATFRPKIKRLLDTFLVPLEERDTDCPAPDVEALLDEALPGEPVFADSATPLSSIVTALSVDASISPARGWRGGSKEAHRRLDDFLGKKLFRYHEDKKDPSLDGLSELSPFLHFGQISPLEVALKARQAVATDLSLDGTGLSLDGTGPSPVGVGPSPNPGLAAFLEELIVRRELAMNFAYYNPAYDQFAALPAWAQATLHSHRLDSREFNYTKAELENACTHDRYWNAAQTELVLRGKMHGYMRMYWGKKILEWTADPERAYRIAVELNDTYALDGRDPNGYTGIAWCFGKHDRPWGERAIFGKVRYMNAAGLRRKFDIEAYVRKVENLVEENEKNGKSGV
>NC_010337.2|WP_012282922.1|1864411_1865116_+|ECF-transporter-S-component
MWPAWPKLQVPLILALAAGSLFASLIGRNIVGRQGWGLLALEMVFLALLLLFWAFERKEICSRELAMIAVLGALAAVGRIPFSALMGIQPVTFLTVLSGAVFGPRAGFMVGATAALVSNFFLGQGPWTPWQMFSWGMAGLSAGLLTRFFPDIGRLWMLAFLFAWGYLYGWIMNFWHWSAFVHPHTGQSFLLTYLASLSFDTVHAIGNCLFYALFGKRFTMILQRFRNKLQVAVS
>NC_010337.2|WP_012282921.1|1862667_1864431_+|energy-coupling-factor-ABC-transporter-ATP-binding-protein
MDLYSLRDLSYFYPEKRQPALRINSLRIEDGEFVLVSGLSGSGKSTLARALAGLVPRFYGGRFSGELRYQGRLLIDLPRRELAREVAIVFQDPEKQLVMTEAEAEIAFGLENLGLSPADMAARIAEVMSFFQLSALKGREIWTLSGGQQQKVALASALAMQPRVLILDEPTSQLDPAAAEEILSLVKRLNEDLAMTIVLVEQRLDRCFHLADRVLYMEEGAIVFNGSPGEMAQWGACRAGTLAPPVARFFAGMGLSPVPITVKAGRKALAALLSREGEPERALSLSPPTTSNASNLPELATLKGRKGVPPANAAVSLDRIWFSYPDGWEALQDVSLSVAPGDFLALLGPNGAGKSTLLRLIAGLLKPGRGRCSLSSAKQGVRSLHAGGRIGYLAQNPNDYLLQDTVEAEVAFGRRNFGLPDDGTVERLLQELRLEAYRGVHPRDLSGGERQRVAIAAVLATDPEILLLDEPTRGMDEQLKDELGALLRRRMDGGAAVILVTHDVEFVARHATRVAILDGGRVVREGGLLTVLGESLFYSTQISRLFRHAAPQLLTPEAAWAAFRDVGRQARKQAEGREADVHVACLA
>NC_010337.2|WP_012281187.1|1872984_1874607_-|IS1182-like-element-ISHmo2-family-transposase
MFRFDVDPQVSFYDFAALWDQLVPADSVFRLFRELAPLLIQPEDFTGLYCLDNGRPSHAARQMTMACMLQEMLGETDRGMEAQTRVNIEVKFALGMALDEPGIDHANFGVHRQRLIQKELDKVYLDRFIRLMYYLGVLTGKEPWITDTTHVIAPISAPTTIELIRQAMRLLVRLLAKQYSVPWHAIPHAPRAVRYLETVTEVKEHNLDDKAKMERLVEVVSEADELLAYVESSEASWKKKPDVIHYALLLCRILRERIIRKDDGTLEIAPGGSVKDMIVSAVDSEARFGCKGKTKWRGYKMAIVEVGNSGFIAAAEAMKANDYDGSSLVPLADQLPTDCVENPTIIGDTHYGAGDDRVTLKEKGIDVVAPLSPKTKCDILAGEGFQVSEDQTQLICPRGKVITTYSEVADGKNFVLRAKDHDCKHCPRYTTCFKEKKHRRTIFIHNAYGVMLEAAKHSQTKIYKEQMRLRSRIEAKQNELVNRYGLRRVRRIGKRNLAYAARLSALAANFQKLNRLRNDKNATMVLEVSALRGVAFKKAA
>NC_010337.2|WP_012282932.1|1874756_1875773_+|IS110-family-transposase
MELFGIEAWVVNAQHIKMVPGRKTDVKDAEWIASLMRHGLLKRSFIPNRPQRELRELLRYRKSMIDERSRELNRMQKVLEGANIKLASVASDILGVSSRKMIEGIIEGQSTPEELAQHAKGRMKAKKDELAKALDGLVGPHQQMMLSEQLKHLDYLDEQIKRLDHAVARQMNMAEELIQLLDTIPGVGRRTAEHLLGEVGLDMSRFPDAAHLASWVGMAPGNNESAGKRKSGRTRKGNKHLRSALVEAGRAATRTKDTFLSAMYHRIAARRGKNRAALAVGHRILVIFYHIVTNREPYKELGANYHDQRRKQSVVNRTVKRLEAMGYKVTIEETSQAA
>NC_010337.2|WP_049754089.1|1876226_1876883_+|TraR/DksA-C4-type-zinc-finger-protein
MNLQQDNQQDNQVDTRNWQEQERWQQCVRFHGHACPGLAIGFRQALIAMEALKVKRDGDEELFAVIETDACGADAVQWLTGCTIGKGNLIYRDRGKHALTLADRKSCQAVRVVTLPGESHRDRRSAELRAKVMAGEATPEERSEWSRLQQARMNDLLRMPVEALFRITAVPMPPVQKARLFNTVVCSRCGEPLAESRARLADGKPVCLDCHPDYSRGW
>NC_010337.2|WP_148207179.1|1876897_1878493_+|ABC-transporter-substrate-binding-protein
MKAWTKQTARPLAGLVTTLFLVMTLLSGCVGQPAQKAVQSGPIDTYTIADPRGDWGFPSPWGHYQRGPGYLRMSFLYDTLIWKDEQGFTPALASHWSYDEGTKAYRFALRDDALWHDGQKVTAGDVLFTFEYMKKHPYPWVDLSEVEKVEAVDAQTVQITLKRHYAPFLENVAGALPILPRHIWAAIERPEEHAEKEVLIGSGPYRLVDYSKEHGTYLYQANDRYYGGKPKVAQIRFVKLNESMAAAALTKGEVDAAQIPGETAEQMRQVGMQVIRGPHFWNAKLMFNHQKAPFSDKAFRQALAYTIDRQELVAKSLRGQGAPASPGLIPPDSPWHEPQVTPYTADLEKARELLASLGYFLEQGSLVKECRELSLELLCSPDNGRDGEIIKEQLARIGIKVRVKSLEAKTVDAKVGAWDFDLAVSGHGGIGGDPQFFSRMITGQGFLSARYNDNSRLNALLNEQLSAMDEEKRKEQVREAQRIYAEDLPALSLYYPTDYWCHNGKVNLFYTQGGISVGIPLPLNKLAFVRP
>NC_010337.2|WP_012282935.1|1878504_1879485_+|ABC-transporter-permease
MFLGKSSRKGLLTHLFALLVLITLNFVLPRSMPGDPLQALGEEALLCMSEETKAELIRRMALDQPLSAQFVSYWVNLLQGDLGYSYAYQAPVSAVIGGALPWTLALTGVSLLLSFSIGLLAGIYSGWRRGHPVDRGLSLAMVALSGLPNYFIGVLLLLLFAVQLGWFPLSGAVTAYAGWTGLRWLGDVIAHMILPVVALTLATLPEFYLLTRSAMVNILDAPFMRTARAKGVGPWRLQFRHGGRNALLPSVARLGVLAGKALTGALFVEMVFAYPGLGHVIHQGLLSRDYPLVQGLFFIVACLVITCNLLADKLLQKLDPRVNDAY
>NC_010337.2|WP_012282936.1|1879474_1880332_+|ABC-transporter-permease
MHINYRQRFISHPLGRLGLTLAAAFAALCLIGPWLSPYAPQATSYALFAPPSGEHWLGTNDVGQDILACLLAGGRTSFLVALGVAFSSTALACLVGALSAMGGGWVDRLLMRLTDVLLAVPHLVLILLVSTYLSPSPWLEIALFSLLLWGPGARVIRAQALSLKERAAVYAAAAFGAGKSYLFARHIFPDLVPLLSVLFLQGARQAVFMEAGLSFIGLADPNTVSWGAMIRHALGFTYLEVWMWCLLPVGAALSVTMVALTCIGHALEEMVKPPVEGHGVEDLYP
>NC_010337.2|WP_012282937.1|1880306_1882052_+|ABC-transporter-ATP-binding-protein
MGLKICIRDVQVCFGGKEIIGGVDLDIARGESVAVIGESGAGKTTLALSLMGLSEGEKAGAIVVEGLPFGEAETDLLRLSEEKWRELRGRHFAMVFQNTANGLNPVIPVLDQVAEAVFVHGLASPEGARKEARQALVKTGFPSRRQNAYPHQLSGGQRQQVMLAMALVNNPDFLILDEPTASLDPITRSEILDCLKGLQRERAMLVITHDLATASALCQRVAVMYRGRIVEEGALSDVFSRPGHPYSRALLRAYPNMTTTKDIQGIRDEWEAMLLSSPAEGYAEATQGASRPRLLRGCAFRPRCTQAVDRCATESPALQGREGRKIACHRGGVIPLIRVEGLSKSFGSVTAVAGLSFSLAEGETLAIVGQSGSGKSTIARLIMGLEKAEAGQLFFEEAPVSARGKDFYRKAQLIFQHPQDAVSHRMTVREALLEPLVIQGLGSREEREERIKKALVEVGFFPSEALLSAYVHYLSGGEAQRLVIARALILNPKLLIADEPTSALDTLAQARILKLLMHLQEQRGLAMIFITHDLALARKVSDRILVLQEGQVVEEGLSWQVTGMPQMPYTQRLIAAAPRLL
>NC_010337.2|WP_012282938.1|1882323_1883172_+|MBL-fold-metallo-hydrolase
MAQLGFEVTFWGVRGSLPVPGPLTTQYGGNTACVQVRIGERDFIIDAGSGLYHLGQALLKNNSGPIRGAFLISHIHWDHIQGFPFFGPAFADQNRFALYGQAKLGRTFADLFRGQMQPPYFPVLLEAMGAQLDFHDLSGGEVLDFDDGITVRTVLTNHPDGCLAYRIEQGGRSCCYLSDTEHCASVDPVLKAFIAGADLVIYDACYTDEEYKGEGLQPSRKGWGHSTWQEGVKLMQAAGAKTLVLFHHAVERTDADMQRIEEMAKAAYPDCLAAREGMTIRL
>NC_010337.2|WP_012282939.1|1883679_1884993_+|diaminopimelate-decarboxylase
MKLHGTATINERGNLAIGGCDATDLIKEFGSPLYVMDEAHLRENCRKYYQAFSASGAGEVLFASKAFMTMAMCRLVEQEGLGLDVVSGGELYTARRAGFPMEKVYFHGNNKTPAELRQAIEYGVGHIVVDNLYEADLLNAIAGETGALVRVLLRITPGIDCHTHEFVRTGQIDSKFGFTLPTGQALAGVKAVLERGNLIYDGLHCHIGSQIFELESFGYAAEVMMTFIDEIRRETGVETAILNLGGGFGIRYTEADTPGDVAEYARIVLSAVALEAEKRGLPTPKVLVEPGRSIVATAGTTLYTVGSVKEIIGVRKYVAVDGGMTDNPRPALYGSRYESMLANKATQEPEEVVSVTGKCCESGDMLLWDVSLPKVESGDILAVSCTGAYNYTMSMNYNRIGRPAVVFVRDGKAAVVVERESLDDLIRNDRIPPYLQR
>NC_010337.2|WP_012282942.1|1885401_1888077_+|CBS-domain-containing-protein
MEIILTHNNTDFDGLAASFAASKLYPRAIPVLAGKLSANVQEFMALHKDTLGFKTIKDIPSQQVKRVILVDTKMASRVGPLGQLTQKPDVDVHIYDHHPAGADDTPASQLVREDVGAVTTILVEILRRRHCRLTPFEATVLALGIYEDTGGLMFSTTTERDAAAVAYLLGRGANLSVINEFIDRPLSKEQKELLRELTSRSVVLVIHGIRVVVTSAELNEYVEGLSHLVHRLGDIESPDVMVAVVRMHDRVHVVARSRIEAVRVNTLLQPLGGGGHGAAAAASIKGGDAALTLEQLVRSLYDTIRPQRGAREIMSSPVKTITPDTTVDDAGKVMLRYGHTGLPVVEGDRLVGVISRRDFDKAYIHGLRHAPVKGFMSRNVITITPDTSLRHIQRLLIEHDIGRLPVLEEGKLVGIVSRTDVLRTLHGENMPVRYWTNFGSARAGEAAPVGTDRQVVDRMRQQLPPHILDLFDDVGRLADGEGVQVYVVGGFVRDLLLGVNNLDIDLVVEGDGICFATELARFLKGTLRTHEKFGTAVIRWGDQKIDVATARREFYQYPAALPQVEASDLRQDLYRRDFTINALAIRLNRERFGELVDFFQGVKDLEQGLVRVLYNLSFVEDPTRILRAIRFEQRYGFTIEPQTMGFAREAIARQMIRELSYERMVDELILILSEENPAPALRRLTELGLWEYLLPGLVWTPWVEVEVSAVPSMLKALAEAGLPVPQRPWVVYFYILARHLSMEGVCFVNDHYPLKQVMRDDLFKLHKEGKDTNQALMNWLRGDDPLSRLESILRDWSEEAILALRAGFSLPDTVRLFEAWRRIRETRPCLTGNDLKALKIPPGPIYARILNRLRRERLDGRLTDAGAERDFVRRLLQEEAPASETKGGNHV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_010337_3	3.8\|602977\|32\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	602977-603008	32	MN694589	Marine virus AFVG_250M1203, complete genome	5754-5785	7	0.781
NC_010337_3	3.11\|603161\|32\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	603161-603192	32	MK878901	Gordonia phage HannahD, complete genome	13770-13801	7	0.781
NC_010337_3	3.11\|603161\|32\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	603161-603192	32	MH479915	Gordonia phage GEazy, complete genome	13770-13801	7	0.781
NC_010337_3	3.11\|603161\|32\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	603161-603192	32	NZ_CP032685	Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence	660113-660144	7	0.781
NC_010337_3	3.11\|603161\|32\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	603161-603192	32	NZ_CP032690	Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence	659662-659693	7	0.781
NC_010337_3	3.11\|603161\|32\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	603161-603192	32	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	228016-228047	7	0.781
NC_010337_2	2.15\|271011\|37\|NC_010337\|CRISPRCasFinder,CRT,PILER-CR	271011-271047	37	MH552475	Siphoviridae sp. isolate ctbe4, complete genome	18182-18218	8	0.784
NC_010337_3	3.11\|603161\|32\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	603161-603192	32	NZ_CP025613	Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence	978823-978854	8	0.75
NC_010337_3	3.13\|603286\|32\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	603286-603317	32	NZ_CP021914	Sagittula sp. P11 plasmid unnamed1, complete sequence	120470-120501	8	0.75
NC_010337_3	3.10\|603100\|32\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	603100-603131	32	MN617843	Mycobacterium phage Quesadilla, complete genome	51182-51213	9	0.719
NC_010337_3	3.14\|603347\|34\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	603347-603380	34	NZ_CP021714	Klebsiella pneumoniae strain AR_0129 plasmid tig00000001, complete sequence	46499-46532	9	0.735
NC_010337_3	3.11\|603161\|32\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	603161-603192	32	MK977695	Gordonia phage Pupper, complete genome	83096-83127	10	0.688
NC_010337_3	3.6\|602853\|32\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	602853-602884	32	NZ_CP021280	Legionella pneumophila subsp. fraseri strain F-4198 plasmid unnamed, complete sequence	58921-58952	11	0.656
NC_010337_3	3.9\|603038\|33\|NC_010337\|PILER-CR,CRISPRCasFinder,CRT	603038-603070	33	MH706966	Enterobacteria phage mEp021, complete genome	45811-45843	11	0.667

1. spacer 3.8|602977|32|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to MN694589 (Marine virus AFVG_250M1203, complete genome) position: , mismatch: 7, identity: 0.781

tcccgtccaaactttcggtcgaatcctacttg	CRISPR spacer
ccccgtccatactttcggtcgaatgagtctcg	Protospacer
.******** **************    **.*

2. spacer 3.11|603161|32|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to MK878901 (Gordonia phage HannahD, complete genome) position: , mismatch: 7, identity: 0.781

gccgggccggtgaatcggccgttgctggatgt-	CRISPR spacer
cccgggccggtgagtcggccgttgc-ggtcacg	Protospacer
 ************.*********** ** ...

3. spacer 3.11|603161|32|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to MH479915 (Gordonia phage GEazy, complete genome) position: , mismatch: 7, identity: 0.781

gccgggccggtgaatcggccgttgctggatgt-	CRISPR spacer
cccgggccggtgagtcggccgttgc-ggtcacg	Protospacer
 ************.*********** ** ...

4. spacer 3.11|603161|32|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032685 (Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence) position: , mismatch: 7, identity: 0.781

gccgggccggtgaatcggccgttgctggatgt	CRISPR spacer
ggcgggccagtcaatcggccgttgcggcagat	Protospacer
* ******.** ************* * * .*

5. spacer 3.11|603161|32|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032690 (Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence) position: , mismatch: 7, identity: 0.781

gccgggccggtgaatcggccgttgctggatgt	CRISPR spacer
ggcgggccagtcaatcggccgttgcggcagat	Protospacer
* ******.** ************* * * .*

6. spacer 3.11|603161|32|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 7, identity: 0.781

gccgggccggtgaatcggccgttgctggatgt-	CRISPR spacer
ccgatgccggtgaatgggccgttgccgg-tgta	Protospacer
 * . ********** *********.** ***

7. spacer 2.15|271011|37|NC_010337|CRISPRCasFinder,CRT,PILER-CR matches to MH552475 (Siphoviridae sp. isolate ctbe4, complete genome) position: , mismatch: 8, identity: 0.784

tcgttgattttctggtcgagatgccacagtcgctgtt	CRISPR spacer
tcattgatcttctggtcgagatgccacagctcaagct	Protospacer
**.*****.********************..   *.*

8. spacer 3.11|603161|32|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP025613 (Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

gccgggccggtgaatcggccgttgctggatgt	CRISPR spacer
gaggggccggtggatgggccgttgctgaagac	Protospacer
*  *********.** ***********.* ..

9. spacer 3.13|603286|32|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021914 (Sagittula sp. P11 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

ccgaaagtcccaaaatctacaacatcgacctt	CRISPR spacer
ccggctcgcccaacctctacaacatcgacctc	Protospacer
***.    *****  ****************.

10. spacer 3.10|603100|32|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to MN617843 (Mycobacterium phage Quesadilla, complete genome) position: , mismatch: 9, identity: 0.719

ggacccttcccttccgtctccttgccctccag	CRISPR spacer
gagaagtcgccatccgactccttgccctccag	Protospacer
*..   *. ** **** ***************

11. spacer 3.14|603347|34|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021714 (Klebsiella pneumoniae strain AR_0129 plasmid tig00000001, complete sequence) position: , mismatch: 9, identity: 0.735

ttcaaagggtaaatgggccggcaagccactactc	CRISPR spacer
gccaaagggtaaatgcgctggcaagctgattcgc	Protospacer
 .************* **.*******.. * * *

12. spacer 3.11|603161|32|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to MK977695 (Gordonia phage Pupper, complete genome) position: , mismatch: 10, identity: 0.688

gccgggccggtgaatcggccgttgctggatgt	CRISPR spacer
cccgggccgttgaatccgccgttggcaccctt	Protospacer
 ******** ****** ******* ..  . *

13. spacer 3.6|602853|32|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021280 (Legionella pneumophila subsp. fraseri strain F-4198 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.656

ataaatgggcctcatgaaggatcgtttaacct	CRISPR spacer
ggcaatcggcctcatgaaggatggttgtgata	Protospacer
.  *** *************** ***  . .

14. spacer 3.9|603038|33|NC_010337|PILER-CR,CRISPRCasFinder,CRT matches to MH706966 (Enterobacteria phage mEp021, complete genome) position: , mismatch: 11, identity: 0.667

gttgccgttgagaacaaggttggcgagggcttc	CRISPR spacer
accagcgttgaaaacaaggttggccagggtaga	Protospacer
.... ******.************ ****.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

5624 : 46816

uncultured_Mediterranean_phage(18.18%)

transposase,lysis,integrase

attL 12450:12472|attR 46817:46839

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012281183.1\|5624_6254_-\|lysis	5-bromo-4-chloroindolyl phosphate hydrolysis family protein	NA	NA	NA	NA
WP_041314100.1\|6562_7291_+	uracil-DNA glycosylase	NA	NA	NA	NA
WP_012281187.1\|7835_9458_+\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_012281188.1\|9496_9826_-	DUF4405 domain-containing protein	NA	NA	NA	NA
WP_012281189.1\|10108_11989_-	molecular chaperone HtpG	A0A1B1ISV4	uncultured_Mediterranean_phage	7.1e-90	34.6
12450:12472	attL	NA	NA	NA	NA
WP_012281191.1\|12860_14204_-\|transposase	IS1380-like element ISHmo1 family transposase	NA	NA	NA	NA
WP_012281192.1\|14436_14802_+	hypothetical protein	NA	NA	NA	NA
WP_012281193.1\|14975_15302_-\|transposase	transposase	NA	NA	NA	NA
WP_012281195.1\|15597_16254_+	glycosyltransferase	NA	NA	NA	NA
WP_148207034.1\|16723_17491_+	hypothetical protein	NA	NA	NA	NA
WP_012281199.1\|17576_18086_+	DUF3794 domain-containing protein	NA	NA	NA	NA
WP_012281200.1\|18269_18794_+	hypothetical protein	NA	NA	NA	NA
WP_012281201.1\|18926_19403_-	hypothetical protein	NA	NA	NA	NA
WP_012281202.1\|19755_21378_-\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_012281204.1\|22175_23603_+	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	4.3e-31	32.8
WP_148207148.1\|23654_24359_-\|transposase	transposase	NA	NA	NA	NA
WP_012281206.1\|25202_25607_+	hypothetical protein	NA	NA	NA	NA
WP_012281207.1\|25835_27179_-\|transposase	IS1380-like element ISHmo1 family transposase	NA	NA	NA	NA
WP_041312978.1\|27272_28052_-	hypothetical protein	NA	NA	NA	NA
WP_012281209.1\|28263_28413_-	hypothetical protein	NA	NA	NA	NA
WP_012281210.1\|28780_29125_-	hypothetical protein	U6C6J3	Ralstonia_phage	4.7e-16	45.7
WP_012281211.1\|29137_29446_-	hypothetical protein	NA	NA	NA	NA
WP_083765262.1\|29467_30439_-	DUF5131 family protein	A0A1B1IPY1	uncultured_Mediterranean_phage	2.4e-25	30.6
WP_041312981.1\|30438_30672_-	hypothetical protein	NA	NA	NA	NA
WP_012281213.1\|30758_30914_-	hypothetical protein	NA	NA	NA	NA
WP_012281214.1\|30924_31248_-	hypothetical protein	NA	NA	NA	NA
WP_041312984.1\|31399_31642_-	hypothetical protein	NA	NA	NA	NA
WP_012281215.1\|31737_32148_-	hypothetical protein	H7BV88	unidentified_phage	2.7e-10	37.7
WP_012281216.1\|32144_32339_-	DUF3873 family protein	NA	NA	NA	NA
WP_012281218.1\|32924_33680_+	Fic family protein	A0A1V0E025	Clostridioides_phage	9.7e-06	36.3
WP_012281219.1\|33809_34079_-	hypothetical protein	NA	NA	NA	NA
WP_012281220.1\|34238_34574_+	hypothetical protein	NA	NA	NA	NA
WP_012281221.1\|34659_35136_+	hypothetical protein	NA	NA	NA	NA
WP_041312987.1\|35135_35714_+	hypothetical protein	NA	NA	NA	NA
WP_018035429.1\|36079_36583_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_012281222.1\|36579_39891_-	tape measure protein	A0A127AW00	Bacillus_phage	6.6e-06	32.2
WP_012281223.1\|39976_41374_-	hypothetical protein	A0A1B0XTI8	Freshwater_phage	1.7e-109	46.1
WP_012281224.1\|41407_41701_-	hypothetical protein	NA	NA	NA	NA
WP_012281225.1\|41728_42682_-	hypothetical protein	NA	NA	NA	NA
WP_012281226.1\|42696_43413_-	hypothetical protein	NA	NA	NA	NA
WP_012281227.1\|43529_44546_-	DUF4373 domain-containing protein	H7BVX7	unidentified_phage	1.6e-27	60.4
WP_012281228.1\|44608_44836_-	hypothetical protein	NA	NA	NA	NA
WP_049753980.1\|45038_45656_+	helix-turn-helix transcriptional regulator	X5JA02	Clostridium_phage	3.2e-07	46.6
WP_012281230.1\|45709_46816_+\|integrase	site-specific integrase	Q8SBN2	Clostridium_phage	3.5e-113	56.1
46817:46839	attR	NA	NA	NA	NA

DBSCAN-SWA_2

152111 : 267656

Bacillus_phage(15.0%)

transposase,tail,tRNA,integrase

attL 180729:180745|attR 252323:252339

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_083765263.1\|152111_152408_-\|tail	tail fiber protein	NA	NA	NA	NA
WP_012281312.1\|153052_154141_-	hypothetical protein	NA	NA	NA	NA
WP_049753992.1\|154254_160953_-	immunoglobulin domain-containing protein	M1FGL0	Enterobacteriaphage	2.9e-16	33.1
WP_083764956.1\|163210_166207_-	response regulator	Q8QKV7	Ectocarpus_siliculosus_virus	2.5e-44	32.5
WP_012281317.1\|166328_167027_+	response regulator transcription factor	W8CYM9	Bacillus_phage	9.8e-37	35.9
WP_012281318.1\|167086_167701_-	hypothetical protein	A0A2K9V3H4	Faecalibacterium_phage	7.8e-30	41.2
WP_012281319.1\|167762_168566_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_012281320.1\|168565_170182_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_012281321.1\|170178_171615_-	SAM-dependent DNA methyltransferase	A0A1V0SLK8	Klosneuvirus	4.2e-34	31.5
WP_012281322.1\|171633_173973_-	DEAD/DEAH box helicase family protein	A0A0E3JPC8	Verrucomicrobia_phage	2.3e-05	37.1
WP_012281323.1\|173998_174178_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012281326.1\|175819_176233_-	hypothetical protein	NA	NA	NA	NA
WP_049753994.1\|176243_176471_-	hypothetical protein	NA	NA	NA	NA
WP_012281329.1\|176795_177011_-	helix-turn-helix transcriptional regulator	A0A2K5B261	Erysipelothrix_phage	2.1e-22	74.6
WP_012281330.1\|177281_177536_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012281331.1\|177547_179368_-	type IV secretory system conjugative DNA transfer family protein	NA	NA	NA	NA
WP_012281332.1\|179424_180930_-	DUF3991 domain-containing protein	NA	NA	NA	NA
180729:180745	attL	NA	NA	NA	NA
WP_012281334.1\|181079_182864_-	SEL1-like repeat protein	NA	NA	NA	NA
WP_041313024.1\|182875_183283_-	hypothetical protein	NA	NA	NA	NA
WP_012281336.1\|183687_183945_-	hypothetical protein	NA	NA	NA	NA
WP_012281337.1\|184055_184349_-	hypothetical protein	NA	NA	NA	NA
WP_012281338.1\|184353_185235_-	ParM/StbA family protein	NA	NA	NA	NA
WP_012281339.1\|185268_185634_-	hypothetical protein	NA	NA	NA	NA
WP_012281340.1\|185651_186737_-	M23 family metallopeptidase	I2E8W3	Clostridium_phage	1.9e-26	50.4
WP_012281341.1\|186741_187236_-	gamma-glutamylcyclotransferase	NA	NA	NA	NA
WP_012281343.1\|188071_189097_-\|integrase	site-specific integrase	S5M872	Bacillus_phage	1.4e-07	23.9
WP_148207041.1\|189093_190083_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012281345.1\|190079_191303_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012281347.1\|191372_191801_-	amidoligase family protein	A0A2K9V489	Faecalibacterium_phage	3.1e-25	50.9
WP_012281348.1\|191868_193701_-	DUF87 domain-containing protein	NA	NA	NA	NA
WP_012281349.1\|193880_194516_-	Fic family protein	NA	NA	NA	NA
WP_015049870.1\|194499_194691_-	hypothetical protein	NA	NA	NA	NA
WP_012281351.1\|194800_195391_-	hypothetical protein	NA	NA	NA	NA
WP_012281352.1\|195387_195690_-	hypothetical protein	NA	NA	NA	NA
WP_012281353.1\|195703_196273_-	hypothetical protein	A0A2K5B270	Erysipelothrix_phage	1.0e-20	47.5
WP_015049869.1\|196269_197127_-	hypothetical protein	NA	NA	NA	NA
WP_012281355.1\|197201_197543_-	DUF3852 domain-containing protein	NA	NA	NA	NA
WP_012281356.1\|197772_198822_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012281357.1\|198811_199792_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012281358.1\|199775_201041_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012281359.1\|201180_202869_-	hypothetical protein	NA	NA	NA	NA
WP_012281360.1\|202944_203499_-	hypothetical protein	NA	NA	NA	NA
WP_012281361.1\|203591_204143_-	hypothetical protein	NA	NA	NA	NA
WP_012281362.1\|204139_204535_-	DUF4320 family protein	NA	NA	NA	NA
WP_012281364.1\|204647_205520_-	hypothetical protein	NA	NA	NA	NA
WP_012281365.1\|205526_206456_-	membrane protein	NA	NA	NA	NA
WP_012281366.1\|206452_207904_-	CpaF family protein	NA	NA	NA	NA
WP_012281367.1\|207900_208716_-	AAA family ATPase	NA	NA	NA	NA
WP_012281368.1\|208718_209531_-	Flp pilus assembly protein CpaB	NA	NA	NA	NA
WP_012281369.1\|209527_209989_-	prepilin peptidase	NA	NA	NA	NA
WP_012281370.1\|209978_210209_-	hypothetical protein	NA	NA	NA	NA
WP_012281371.1\|210321_210702_-	hypothetical protein	NA	NA	NA	NA
WP_012281372.1\|210743_210962_-	hypothetical protein	NA	NA	NA	NA
WP_012281373.1\|211009_211396_-	septation protein SpoVG family protein	NA	NA	NA	NA
WP_012281374.1\|211461_212022_-	hypothetical protein	NA	NA	NA	NA
WP_012281375.1\|212057_216641_-	S-layer homology domain-containing protein	NA	NA	NA	NA
WP_012281376.1\|216744_217329_-	hypothetical protein	NA	NA	NA	NA
WP_012281377.1\|217341_217626_-	hypothetical protein	NA	NA	NA	NA
WP_012281378.1\|217615_218038_-	hypothetical protein	NA	NA	NA	NA
WP_012281379.1\|218109_219045_-	DNA adenine methylase	A0A2H4IYF4	uncultured_Caudovirales_phage	3.9e-57	42.9
WP_012281380.1\|219052_219253_-	hypothetical protein	NA	NA	NA	NA
WP_012281381.1\|219354_219954_-	hypothetical protein	NA	NA	NA	NA
WP_012281382.1\|219955_220483_-	hypothetical protein	NA	NA	NA	NA
WP_012281384.1\|227187_228162_-	diguanylate cyclase	Q6XM27	Feldmannia_irregularis_virus	5.6e-06	28.0
WP_012281385.1\|228240_230970_-	response regulator	A0A1V0SGX0	Hokovirus	2.9e-76	34.0
WP_012281386.1\|231005_231404_-	Hpt domain-containing protein	NA	NA	NA	NA
WP_012281387.1\|231623_233438_-	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	5.8e-65	27.6
WP_012281388.1\|233562_235605_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	9.3e-11	30.8
WP_012281389.1\|235841_237473_-	putative manganese-dependent inorganic diphosphatase	NA	NA	NA	NA
WP_148207152.1\|237496_238504_-	cation diffusion facilitator family transporter	NA	NA	NA	NA
WP_012281391.1\|238679_239777_-	S-layer homology domain-containing protein	NA	NA	NA	NA
WP_012281392.1\|239884_240541_-	Fe-S cluster protein	NA	NA	NA	NA
WP_012281393.1\|240542_241253_-	cobalamin biosynthesis protein	NA	NA	NA	NA
WP_012281394.1\|241268_242048_-	ATP-binding cassette domain-containing protein	NA	NA	NA	NA
WP_012281396.1\|242464_243631_-	flavodoxin domain-containing protein	NA	NA	NA	NA
WP_012281397.1\|243766_244978_-	hypothetical protein	NA	NA	NA	NA
WP_012281398.1\|244991_245198_-	hypothetical protein	NA	NA	NA	NA
WP_012281399.1\|245200_245821_-	RNA polymerase sigma factor	NA	NA	NA	NA
WP_012281400.1\|245987_246803_-	M48 family metallopeptidase	NA	NA	NA	NA
WP_041313040.1\|246909_247137_+	hypothetical protein	NA	NA	NA	NA
WP_012281403.1\|247345_248128_-	transcriptional repressor LexA	A0A1B1P7Q3	Bacillus_phage	6.5e-13	53.6
WP_148207042.1\|248526_248805_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	A0A2I7SC16	Paenibacillus_phage	1.4e-18	57.0
WP_012281405.1\|248969_249116_+	hypothetical protein	NA	NA	NA	NA
WP_148207153.1\|249271_249472_-	hypothetical protein	NA	NA	NA	NA
WP_012281407.1\|249495_250950_-	U32 family peptidase C-terminal domain-containing protein	Q6DW11	Phage_TP	9.2e-53	36.4
WP_012281408.1\|250939_251956_-	endolytic transglycosylase MltG	NA	NA	NA	NA
WP_012281410.1\|252149_252419_-	DUF1292 domain-containing protein	NA	NA	NA	NA
252323:252339	attR	NA	NA	NA	NA
WP_012281411.1\|252570_253020_-	Holliday junction resolvase RuvX	NA	NA	NA	NA
WP_041314231.1\|253024_253987_-	aldo/keto reductase	NA	NA	NA	NA
WP_012281413.1\|254045_254324_-	IreB family regulatory phosphoprotein	NA	NA	NA	NA
WP_012281414.1\|254486_257138_-\|tRNA	alanine--tRNA ligase	A0A2K9L1X7	Tupanvirus	3.9e-86	39.1
WP_012281416.1\|257537_258359_-	sirohydrochlorin cobaltochelatase	NA	NA	NA	NA
WP_012281187.1\|258531_260154_+\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_041313043.1\|261058_261655_-	hypothetical protein	NA	NA	NA	NA
WP_012281418.1\|261721_263071_-	dNTP triphosphohydrolase	NA	NA	NA	NA
WP_148207043.1\|263665_264712_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_012281420.1\|264600_264927_-\|transposase	transposase	NA	NA	NA	NA
WP_148207154.1\|265036_265741_+\|transposase	transposase	NA	NA	NA	NA
WP_012281187.1\|266033_267656_+\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

556496 : 672945

Streptococcus_phage(19.05%)

transposase,holin,tRNA,coat,integrase

attL 559499:559514|attR 631373:631388

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012281712.1\|556496_557186_-\|tRNA	tRNA (guanosine(46)-N7)-methyltransferase TrmB	NA	NA	NA	NA
WP_083765033.1\|557250_558282_-	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_148207061.1\|558404_558881_-	hypothetical protein	NA	NA	NA	NA
WP_049754213.1\|558974_560591_-	alpha-glucan family phosphorylase	NA	NA	NA	NA
559499:559514	attL	NA	NA	NA	NA
WP_012281716.1\|560823_561000_-	hypothetical protein	NA	NA	NA	NA
WP_012281717.1\|561122_562346_+	HD domain-containing protein	NA	NA	NA	NA
WP_012281718.1\|562421_562793_-	adenosylmethionine decarboxylase	A0A222YVV4	Synechococcus_phage	1.9e-15	37.8
WP_012281720.1\|563568_564243_+	energy-coupling factor ABC transporter permease	NA	NA	NA	NA
WP_012281721.1\|564239_564482_+	energy-coupling factor ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_012281187.1\|564620_566243_+\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_012281723.1\|566683_567403_+	cobalt ECF transporter T component CbiQ	NA	NA	NA	NA
WP_012281724.1\|567423_568296_+	ATP-binding cassette domain-containing protein	NA	NA	NA	NA
WP_012281725.1\|568353_569037_-	Ni/Fe-hydrogenase, b-type cytochrome subunit	NA	NA	NA	NA
WP_012281726.1\|569049_570786_-	nickel-dependent hydrogenase large subunit	NA	NA	NA	NA
WP_041313160.1\|570793_571909_-	hydrogenase small subunit	NA	NA	NA	NA
WP_012281728.1\|572204_573077_-	hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	NA	NA	NA	NA
WP_012281729.1\|573225_574347_-	thiamine-phosphate kinase	NA	NA	NA	NA
WP_012281731.1\|574511_575822_-	phosphomethylpyrimidine synthase ThiC	NA	NA	NA	NA
WP_012281733.1\|576364_577480_+	HD-GYP domain-containing protein	NA	NA	NA	NA
WP_012281734.1\|577853_579146_-	hydroxylamine reductase	NA	NA	NA	NA
WP_148207062.1\|579376_580921_+	long-chain-fatty-acid--CoA ligase	Q75ZG1	Hepacivirus	2.1e-47	29.0
WP_012281736.1\|580988_584762_-	PAS domain-containing protein	Q8QKV7	Ectocarpus_siliculosus_virus	5.0e-18	22.7
WP_012281738.1\|585057_586098_-	HD-GYP domain-containing protein	NA	NA	NA	NA
WP_012281739.1\|586261_587413_-	glycerate kinase	W6LM47	Streptococcus_phage	1.5e-37	38.0
WP_041313166.1\|587965_588751_+	basic amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_012281745.1\|589115_589781_+	hypothetical protein	NA	NA	NA	NA
WP_041313169.1\|590112_590382_-	type I-E CRISPR-associated endoribonuclease Cas2	NA	NA	NA	NA
WP_012281746.1\|590402_591335_-	type I-E CRISPR-associated endonuclease Cas1	NA	NA	NA	NA
WP_041313172.1\|591337_592024_-	type I-E CRISPR-associated protein Cas6/Cse3/CasE	NA	NA	NA	NA
WP_012281747.1\|592010_592703_-	type I-E CRISPR-associated protein Cas5/CasD	NA	NA	NA	NA
WP_049754013.1\|592705_593866_-	type I-E CRISPR-associated protein Cas7/Cse4/CasC	NA	NA	NA	NA
WP_012281749.1\|593865_594429_-	type I-E CRISPR-associated protein Cse2/CasB	NA	NA	NA	NA
WP_012281750.1\|594438_596010_-	type I-E CRISPR-associated protein Cse1/CasA	NA	NA	NA	NA
WP_148207064.1\|595993_598147_-	CRISPR-associated helicase Cas3'	A0A2R2ZGW0	Clostridioides_phage	2.1e-05	21.8
WP_041313175.1\|598330_598546_+	hypothetical protein	NA	NA	NA	NA
WP_012281187.1\|598683_600306_+\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_012281426.1\|600852_602214_-\|transposase	transposase	NA	NA	NA	NA
WP_012281755.1\|605845_606634_-	P-loop NTPase	NA	NA	NA	NA
WP_049754214.1\|606797_607406_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_012281757.1\|607475_608129_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_012281204.1\|608222_609650_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	4.3e-31	32.8
WP_148207065.1\|610083_610947_-	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_041313177.1\|611043_611778_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.3e-35	41.0
WP_012281760.1\|611836_612946_-	HD-GYP domain-containing protein	NA	NA	NA	NA
WP_012281761.1\|613376_613817_+	CBS domain-containing protein	NA	NA	NA	NA
WP_012281762.1\|614017_615157_-	sporulation protein YhbH	X2JIL8	Bacillus_phage	1.0e-19	40.9
WP_012281763.1\|615169_617065_-	PrkA family serine protein kinase	A0MN77	Thermus_phage	3.4e-100	36.3
WP_041313181.1\|617248_619300_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	5.7e-08	82.5
WP_041314436.1\|619597_620734_-	2-hydroxyacyl-CoA dehydratase	NA	NA	NA	NA
WP_041314439.1\|620827_621622_-	2-hydroxyglutaryl-CoA dehydratase	NA	NA	NA	NA
WP_012281767.1\|621937_622804_+	VanW family protein	NA	NA	NA	NA
WP_187147821.1\|623338_623788_+	hypothetical protein	NA	NA	NA	NA
WP_012281769.1\|623839_625195_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	O89815	Mus_dunni_endogenous_virus	6.0e-06	29.4
WP_012281770.1\|625187_625988_+	AAA family ATPase	NA	NA	NA	NA
WP_041313184.1\|626699_627230_-	hypothetical protein	NA	NA	NA	NA
WP_148207066.1\|627226_628063_-	AAA family ATPase	A0A1V0DZZ0	Clostridioides_phage	1.2e-09	29.7
WP_012281773.1\|628423_628750_+\|transposase	transposase	NA	NA	NA	NA
WP_012281775.1\|629114_630737_-\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_148207067.1\|631913_632960_-\|transposase	IS3 family transposase	NA	NA	NA	NA
631373:631388	attR	NA	NA	NA	NA
WP_012281778.1\|632848_633175_-\|transposase	transposase	NA	NA	NA	NA
WP_012281187.1\|633555_635178_-\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_012281191.1\|636094_637438_-\|transposase	IS1380-like element ISHmo1 family transposase	NA	NA	NA	NA
WP_012281191.1\|637800_639144_-\|transposase	IS1380-like element ISHmo1 family transposase	NA	NA	NA	NA
WP_041313187.1\|639398_639623_+	excisionase family DNA-binding protein	A0A1B1IUF9	uncultured_Mediterranean_phage	3.5e-12	50.0
WP_049754215.1\|639663_640812_+	hypothetical protein	A0A139ZPI3	Marinitoga_camini_virus	2.1e-12	25.2
WP_012281782.1\|640826_642539_+	ATP-binding protein	A0A139ZPI2	Marinitoga_camini_virus	4.5e-67	32.1
WP_041313189.1\|642558_644130_+	ATP-binding protein	NA	NA	NA	NA
WP_012281784.1\|644126_645932_+	hypothetical protein	A0A139ZPI1	Marinitoga_camini_virus	5.3e-26	23.5
WP_012281785.1\|647008_648202_+	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_187147832.1\|648551_648821_-	hypothetical protein	NA	NA	NA	NA
WP_049754017.1\|648907_649258_+\|coat	spore coat associated protein CotJA	NA	NA	NA	NA
WP_012281788.1\|649278_649539_+\|coat	spore coat protein CotJB	NA	NA	NA	NA
WP_012281789.1\|649566_650139_+	manganese catalase family protein	NA	NA	NA	NA
WP_012281790.1\|650362_650830_-	SsrA-binding protein SmpB	W5RAM5	Staphylococcus_phage	4.4e-41	56.2
WP_012281791.1\|650933_651515_-	HDIG domain-containing protein	NA	NA	NA	NA
WP_012281792.1\|651586_652015_-	PaaI family thioesterase	NA	NA	NA	NA
WP_187147800.1\|652011_652674_-	twin-arginine translocase subunit TatB	NA	NA	NA	NA
WP_012281794.1\|652824_654882_-	sodium-translocating pyrophosphatase	NA	NA	NA	NA
WP_049754216.1\|654954_655218_-	preprotein translocase subunit SecG	NA	NA	NA	NA
WP_012281796.1\|655660_656950_-	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	6.4e-159	65.3
WP_041314453.1\|657093_658617_-	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	NA	NA	NA	NA
WP_012281187.1\|658846_660469_+\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_012281798.1\|660725_661481_-	triose-phosphate isomerase	NA	NA	NA	NA
WP_012281799.1\|661621_662809_-	phosphoglycerate kinase	NA	NA	NA	NA
WP_012281800.1\|662958_663966_-	type I glyceraldehyde-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_012281801.1\|664126_665428_-	RNA polymerase factor sigma-54	NA	NA	NA	NA
WP_187147822.1\|665471_665810_-	acyltransferase	NA	NA	NA	NA
WP_012281803.1\|665978_666938_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	4.3e-43	35.4
WP_049754217.1\|666960_668322_-	YvcK family protein	A1IMD5	Streptococcus_phage	1.3e-53	40.7
WP_012281805.1\|668330_669236_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	2.9e-12	32.3
WP_148207160.1\|669360_670848_-	4-alpha-glucanotransferase	NA	NA	NA	NA
WP_012281807.1\|670853_672383_-	alpha-amylase	NA	NA	NA	NA
WP_012281809.1\|672600_672945_-\|holin	phage holin family protein	NA	NA	NA	NA

DBSCAN-SWA_4

718598 : 775921

Acanthamoeba_polyphaga_moumouvirus(14.29%)

transposase,coat

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012281851.1\|718598_719714_-\|coat	spore coat polysaccharide biosynthesis protein spsg/glycosyltransferase	NA	NA	NA	NA
WP_012281853.1\|721100_721880_-	glycosyltransferase family protein	NA	NA	NA	NA
WP_083765268.1\|722037_722304_-	SEC-C domain-containing protein	NA	NA	NA	NA
WP_049754023.1\|722525_726623_+	hypothetical protein	NA	NA	NA	NA
WP_012281856.1\|726685_726988_+	EscU/YscU/HrcU family type III secretion system export apparatus switch protein	NA	NA	NA	NA
WP_012281857.1\|727002_727440_+	YaaR family protein	NA	NA	NA	NA
WP_012281858.1\|727471_728182_+	hypothetical protein	NA	NA	NA	NA
WP_012281859.1\|728490_728955_+	flagellar export chaperone FliS	NA	NA	NA	NA
WP_012281860.1\|729009_730308_+	flagellin	NA	NA	NA	NA
WP_012281861.1\|730413_731505_-	GDP-mannose 4,6-dehydratase	L7RCI0	Acanthamoeba_polyphaga_moumouvirus	3.1e-21	25.9
WP_041313218.1\|731551_732157_-	UDP-4-amino-4, 6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase	NA	NA	NA	NA
WP_012281863.1\|732153_733611_-	AMP-binding protein	NA	NA	NA	NA
WP_148207070.1\|733614_734370_-	SDR family oxidoreductase	F2NZ40	Diadromus_pulchellus_ascovirus	1.7e-05	28.9
WP_049754221.1\|734400_734670_-	hypothetical protein	NA	NA	NA	NA
WP_012281866.1\|734715_735897_-	N-acetylneuraminate synthase family protein	NA	NA	NA	NA
WP_041313220.1\|735953_737048_-	UDP-galactopyranose mutase	Q19CD9	Aeromonas_virus	7.1e-58	38.3
WP_012281868.1\|737092_737620_-	hypothetical protein	NA	NA	NA	NA
WP_187147823.1\|737623_739015_-	phosphomannomutase	A0A127AWJ1	Bacillus_phage	1.9e-31	27.9
WP_012281870.1\|739065_739578_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_012281187.1\|739679_741302_-\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_012281871.1\|741368_741893_-	glycosyltransferase	NA	NA	NA	NA
WP_012281872.1\|741846_743277_-	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	2.9e-59	30.7
WP_012281873.1\|743301_743583_-	hypothetical protein	NA	NA	NA	NA
WP_012281874.1\|743810_744356_-	hypothetical protein	NA	NA	NA	NA
WP_012281876.1\|744629_746033_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_148207072.1\|746079_746658_-	hypothetical protein	NA	NA	NA	NA
WP_012281187.1\|746829_748452_-\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_012281878.1\|748466_750392_-	hypothetical protein	NA	NA	NA	NA
WP_041313226.1\|750420_752007_-	glycosyltransferase	NA	NA	NA	NA
WP_012281880.1\|752062_753169_-	glycosyltransferase	NA	NA	NA	NA
WP_012281881.1\|753251_754358_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_012281882.1\|754497_755841_+\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_148207162.1\|756077_756227_-	hypothetical protein	NA	NA	NA	NA
WP_012281883.1\|756511_756832_-\|transposase	transposase	NA	NA	NA	NA
WP_012281884.1\|758287_759334_-	FkbM family methyltransferase	NA	NA	NA	NA
WP_012281887.1\|760782_761034_-	hypothetical protein	NA	NA	NA	NA
WP_012281889.1\|761473_762484_-	polysaccharide biosynthesis protein	A0A1V0SAI8	Catovirus	1.2e-35	30.7
WP_012281890.1\|762595_763147_-	hypothetical protein	NA	NA	NA	NA
WP_012281891.1\|763246_763687_-	flagellar protein FlaG	NA	NA	NA	NA
WP_012281892.1\|763790_765596_-	motility associated factor glycosyltransferase family protein	NA	NA	NA	NA
WP_041314516.1\|765674_766049_-	flagellar export chaperone FliS	NA	NA	NA	NA
WP_012281894.1\|766342_766750_-	hypothetical protein	NA	NA	NA	NA
WP_012281895.1\|766753_768334_-	flagellar filament capping protein FliD	NA	NA	NA	NA
WP_041313243.1\|768534_769761_-	flagellin	NA	NA	NA	NA
WP_012281897.1\|769907_770171_-	carbon storage regulator CsrA	H2BD56	Pseudomonas_phage	5.5e-09	52.9
WP_012281898.1\|770171_770633_-	flagellar assembly protein FliW	NA	NA	NA	NA
WP_012281899.1\|770675_771086_-	hypothetical protein	NA	NA	NA	NA
WP_012281900.1\|771319_772249_-	flagellar hook-associated protein FlgL	NA	NA	NA	NA
WP_012281901.1\|772292_774503_-	flagellar hook-associated protein FlgK	NA	NA	NA	NA
WP_012281902.1\|774772_775921_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	NA	NA	NA	NA

DBSCAN-SWA_5

789686 : 833365

Klosneuvirus(14.29%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148207074.1\|789686_790034_-\|transposase	transposase	NA	NA	NA	NA
WP_041314529.1\|790248_791343_-	undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase	NA	NA	NA	NA
WP_041313251.1\|791500_791941_-	3-hydroxyacyl-ACP dehydratase FabZ	NA	NA	NA	NA
WP_049754027.1\|791985_792306_-	hypothetical protein	NA	NA	NA	NA
WP_012281923.1\|792429_792918_+	DUF4330 domain-containing protein	NA	NA	NA	NA
WP_012281924.1\|793264_794542_-	glycosyltransferase	NA	NA	NA	NA
WP_041313254.1\|794637_796569_+	O-antigen ligase family protein	NA	NA	NA	NA
WP_041314540.1\|796692_797040_+	EamA family transporter	NA	NA	NA	NA
WP_012281927.1\|797611_798745_-	glycosyltransferase	A0A1V0SL50	Klosneuvirus	8.0e-20	27.2
WP_012281928.1\|798964_799498_-	DUF2304 domain-containing protein	NA	NA	NA	NA
WP_083765089.1\|799494_800301_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_012281930.1\|800452_801157_-	hypothetical protein	NA	NA	NA	NA
WP_083765091.1\|801373_801556_+	ATP-binding protein	NA	NA	NA	NA
WP_012281931.1\|801615_802551_-	dTDP-4-dehydrorhamnose reductase	NA	NA	NA	NA
WP_148207075.1\|802660_803791_-	ATP-binding cassette domain-containing protein	Q6GZ03	Mycoplasma_phage	2.3e-27	34.9
WP_012281933.1\|803747_804233_-	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_187147802.1\|804251_805049_-	sulfate ABC transporter permease subunit	NA	NA	NA	NA
WP_049754030.1\|805045_805870_-	sulfate ABC transporter permease subunit	NA	NA	NA	NA
WP_012281936.1\|805866_806907_-	sulfate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_012281187.1\|807125_808748_-\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_012281937.1\|809042_810917_-	sulfate adenylyltransferase subunit CysN	A0A1V0SGC3	Hokovirus	2.6e-31	25.2
WP_012281938.1\|810916_811816_-	sulfate adenylyltransferase subunit CysD	NA	NA	NA	NA
WP_041313263.1\|813857_815084_-	L-2-hydroxyglutarate oxidase	NA	NA	NA	NA
WP_012281942.1\|815073_816216_-	sulfotransferase domain-containing protein	NA	NA	NA	NA
WP_012281943.1\|816226_816502_-	hypothetical protein	NA	NA	NA	NA
WP_012281945.1\|817130_817643_+\|transposase	transposase	NA	NA	NA	NA
WP_012281946.1\|817639_817960_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012281939.1\|818405_819158_+\|transposase	transposase	NA	NA	NA	NA
WP_187147803.1\|819264_819633_-	FkbM family methyltransferase	NA	NA	NA	NA
WP_083765093.1\|820302_820509_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	7.9e-11	48.3
WP_012281952.1\|822773_823967_-	D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase	M1I080	Acanthocystis_turfacea_Chlorella_virus	3.7e-07	23.2
WP_012281953.1\|823974_825090_-	hypothetical protein	NA	NA	NA	NA
WP_041313271.1\|825094_827224_-	hypothetical protein	NA	NA	NA	NA
WP_041314558.1\|827226_827814_-	D-sedoheptulose 7-phosphate isomerase	NA	NA	NA	NA
WP_012281956.1\|827888_828821_-	NAD-dependent epimerase/dehydratase	A0A0F7LC08	uncultured_marine_virus	3.0e-73	46.3
WP_012281957.1\|829127_830471_-\|transposase	IS1380-like element ISHmo1 family transposase	NA	NA	NA	NA
WP_012281958.1\|830572_831556_-	GHMP kinase	A0A067XQL1	Caulobacter_phage	1.2e-27	29.6
WP_012281959.1\|831715_833365_+\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_6

1019353 : 1066838

Pseudomonas_phage(22.22%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012282120.1\|1019353_1021330_-\|protease	ATP-dependent protease, Lon family	A0A0R6PGP8	Moraxella_phage	9.6e-29	28.8
WP_012282121.1\|1021434_1021881_-	50S ribosomal protein L9	NA	NA	NA	NA
WP_049754038.1\|1022068_1024099_-	DHH family phosphoesterase	NA	NA	NA	NA
WP_012282123.1\|1024134_1025106_-	YybS family protein	NA	NA	NA	NA
WP_012282124.1\|1025333_1025870_-	single-stranded DNA-binding protein	A0A0K2CYR2	Paenibacillus_phage	9.6e-24	50.9
WP_012282125.1\|1025963_1027064_-	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_012282126.1\|1027252_1027396_+	hypothetical protein	NA	NA	NA	NA
WP_012282127.1\|1027518_1028604_+	hypothetical protein	NA	NA	NA	NA
WP_012282128.1\|1028737_1028947_-	DUF951 domain-containing protein	NA	NA	NA	NA
WP_049754225.1\|1028952_1029834_-	mechanosensitive ion channel family protein	NA	NA	NA	NA
WP_012282130.1\|1029887_1030892_-	HEAT repeat domain-containing protein	NA	NA	NA	NA
WP_012282131.1\|1030898_1031324_-	sulfurtransferase-like selenium metabolism protein YedF	NA	NA	NA	NA
WP_049754226.1\|1031353_1032805_-	aminopeptidase	NA	NA	NA	NA
WP_012282133.1\|1032855_1033581_-	CvpA family protein	NA	NA	NA	NA
WP_012282134.1\|1033654_1034629_-	ATP-binding protein	A0A1B1P7U2	Bacillus_phage	2.9e-18	29.3
WP_041313341.1\|1034640_1036023_-	DnaD domain protein	NA	NA	NA	NA
WP_012282136.1\|1036123_1036567_-	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_187147807.1\|1036664_1039208_-	DEAD/DEAH box helicase	F2Y0S4	Organic_Lake_phycodnavirus	6.7e-67	29.0
WP_012282138.1\|1039297_1040188_-	TIGR03943 family protein	NA	NA	NA	NA
WP_012282139.1\|1040201_1041272_-	permease	NA	NA	NA	NA
WP_148207084.1\|1041391_1041778_-	metalloregulator ArsR/SmtB family transcription factor	E4ZFI8	Streptococcus_phage	3.4e-15	36.7
WP_012282141.1\|1042030_1042528_+	hypothetical protein	NA	NA	NA	NA
WP_012282143.1\|1042785_1044507_+	acetate--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	4.2e-190	67.0
WP_148207085.1\|1044683_1046114_+	MFS transporter	NA	NA	NA	NA
WP_012282145.1\|1046177_1046348_+	hypothetical protein	NA	NA	NA	NA
WP_012282146.1\|1046367_1046826_-	DUF441 domain-containing protein	NA	NA	NA	NA
WP_012282147.1\|1046860_1047679_-	2-phosphosulfolactate phosphatase	NA	NA	NA	NA
WP_012282148.1\|1047691_1048534_-	phosphosulfolactate synthase	NA	NA	NA	NA
WP_012282149.1\|1048622_1049588_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_041314679.1\|1049751_1049976_-	MoaD/ThiS family protein	NA	NA	NA	NA
WP_187147808.1\|1050073_1051147_-	endospore germination permease	NA	NA	NA	NA
WP_012282152.1\|1051203_1051422_-	hypothetical protein	NA	NA	NA	NA
WP_041313347.1\|1051424_1052594_-	Ger(x)C family spore germination protein	NA	NA	NA	NA
WP_187147809.1\|1052590_1054135_-	spore germination protein	NA	NA	NA	NA
WP_012281204.1\|1054701_1056129_+	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	4.3e-31	32.8
WP_012282157.1\|1056586_1058014_+	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	7.4e-31	32.8
WP_012281778.1\|1058406_1058733_+\|transposase	transposase	NA	NA	NA	NA
WP_148207087.1\|1058621_1059668_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_187147810.1\|1059985_1061362_+\|transposase	transposase	NA	NA	NA	NA
WP_012281426.1\|1061858_1063220_-\|transposase	transposase	NA	NA	NA	NA
WP_012282160.1\|1063315_1064809_-	hypothetical protein	P79669	Escherichia_phage	1.1e-13	21.7
WP_012281187.1\|1065215_1066838_+\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA

DBSCAN-SWA_7

1508968 : 1574050

Bacillus_phage(20.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012281187.1\|1508968_1510591_+\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_012282593.1\|1510885_1512085_-	EAL domain-containing protein	NA	NA	NA	NA
WP_012282594.1\|1512148_1513126_-	YpdA family putative bacillithiol disulfide reductase	G3MA85	Bacillus_virus	4.6e-08	23.2
WP_012282596.1\|1514368_1515241_+	branched-chain-amino-acid transaminase	NA	NA	NA	NA
WP_041314961.1\|1515316_1516975_+	dihydroxy-acid dehydratase	NA	NA	NA	NA
WP_012282598.1\|1517001_1517484_+	acetolactate synthase small subunit	NA	NA	NA	NA
WP_012282599.1\|1517608_1518604_+	ketol-acid reductoisomerase	NA	NA	NA	NA
WP_083765181.1\|1518635_1520366_+	biosynthetic-type acetolactate synthase large subunit	A0A0P0YLY7	Yellowstone_lake_phycodnavirus	5.6e-57	31.6
WP_012282601.1\|1520515_1522054_+	2-isopropylmalate synthase	E5EQ69	Micromonas_sp._RCC1109_virus	2.0e-05	34.9
WP_012282602.1\|1522329_1523592_+	3-isopropylmalate dehydratase large subunit	NA	NA	NA	NA
WP_012282603.1\|1523591_1524092_+	3-isopropylmalate dehydratase small subunit	NA	NA	NA	NA
WP_012282604.1\|1524342_1525413_+	3-isopropylmalate dehydrogenase	NA	NA	NA	NA
WP_012282605.1\|1525712_1527308_+	citramalate synthase	NA	NA	NA	NA
WP_012282607.1\|1527542_1527920_-	small basic family protein	NA	NA	NA	NA
WP_012282608.1\|1528046_1528859_+	TIGR00159 family protein	NA	NA	NA	NA
WP_012282609.1\|1528855_1529953_+	hypothetical protein	NA	NA	NA	NA
WP_012282610.1\|1529977_1531660_+	hypothetical protein	NA	NA	NA	NA
WP_012282611.1\|1531793_1533173_+	phosphoglucosamine mutase	NA	NA	NA	NA
WP_041313496.1\|1533775_1535602_+	glutamine--fructose-6-phosphate transaminase (isomerizing)	M1HQK2	Paramecium_bursaria_Chlorella_virus	2.5e-108	40.3
WP_012282613.1\|1535846_1537103_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_012282614.1\|1537291_1538224_-	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	3.6e-10	21.6
WP_012282616.1\|1538577_1539126_+	NADH peroxidase	NA	NA	NA	NA
WP_012282617.1\|1539267_1540560_+	hypothetical protein	NA	NA	NA	NA
WP_187147826.1\|1541831_1543661_+	hypothetical protein	D4P754	Rhodococcus_phage	1.3e-35	27.0
WP_012282621.1\|1543960_1544632_+	response regulator transcription factor	W8CYM9	Bacillus_phage	9.4e-37	39.8
WP_012282622.1\|1544634_1546080_+	two-component sensor histidine kinase	W8CYF6	Bacillus_phage	2.0e-31	34.8
WP_012282623.1\|1546492_1547308_+	hypothetical protein	NA	NA	NA	NA
WP_041313504.1\|1547468_1548719_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_012282627.1\|1548731_1551851_+	efflux RND transporter permease subunit	NA	NA	NA	NA
WP_012282628.1\|1551925_1552555_-	DUF3793 family protein	NA	NA	NA	NA
WP_012282629.1\|1552843_1553524_+	ZIP family metal transporter	NA	NA	NA	NA
WP_012282630.1\|1553616_1554957_-	Na+/H+ antiporter NhaA	A0A2H4J5W3	uncultured_Caudovirales_phage	4.0e-79	46.4
WP_012282631.1\|1555565_1556966_+	sodium:alanine symporter family protein	NA	NA	NA	NA
WP_012282632.1\|1557010_1558228_-	reductive dehalogenase	NA	NA	NA	NA
WP_041313507.1\|1558354_1559176_-	molybdate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_012282637.1\|1561429_1561588_-	DUF1540 domain-containing protein	NA	NA	NA	NA
WP_148207172.1\|1561689_1562376_-	YjbE family putative metal transport protein	W8EBD0	Pseudomonas_phage	1.1e-27	39.3
WP_012282640.1\|1563095_1564193_-	YibE/F family protein	NA	NA	NA	NA
WP_187147756.1\|1564230_1564476_-	hypothetical protein	NA	NA	NA	NA
WP_148207100.1\|1565952_1566999_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_012282646.1\|1566887_1567214_-\|transposase	transposase	NA	NA	NA	NA
WP_012282647.1\|1567615_1569265_+\|transposase	transposase	NA	NA	NA	NA
WP_148207101.1\|1569475_1569751_+	hypothetical protein	NA	NA	NA	NA
WP_012281187.1\|1569884_1571507_-\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_148207102.1\|1571716_1572202_+	hypothetical protein	NA	NA	NA	NA
WP_012282648.1\|1572427_1574050_-\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA

DBSCAN-SWA_8

2802346 : 2859397

Erysipelothrix_phage(66.67%)

portal,transposase,holin,protease,capsid,head,tail,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012281191.1\|2802346_2803690_-\|transposase	IS1380-like element ISHmo1 family transposase	NA	NA	NA	NA
WP_083765251.1\|2804001_2804607_-	DUF2703 domain-containing protein	NA	NA	NA	NA
WP_148207139.1\|2804689_2805256_-	RNA polymerase sigma factor SigZ	NA	NA	NA	NA
WP_041313971.1\|2805291_2805828_-	permease	NA	NA	NA	NA
WP_041313973.1\|2805824_2806304_-	permease	NA	NA	NA	NA
WP_083765252.1\|2806453_2806690_-	ferredoxin family protein	NA	NA	NA	NA
WP_012283846.1\|2806905_2808267_+\|transposase	transposase	NA	NA	NA	NA
WP_083765253.1\|2809005_2809860_-	restriction endonuclease	NA	NA	NA	NA
WP_012283848.1\|2809867_2810827_-	DNA cytosine methyltransferase	A0A1S5SAY6	Streptococcus_phage	6.3e-26	27.7
WP_012283849.1\|2810895_2811357_-	very short patch repair endonuclease	V5UTF4	Oenococcus_phage	2.8e-32	58.3
WP_012283850.1\|2811387_2813919_-	S8 family peptidase	NA	NA	NA	NA
WP_012283851.1\|2813938_2814934_-	AAA family ATPase	A0A1S5V1G7	Saudi_moumouvirus	2.7e-16	31.5
WP_041313976.1\|2814980_2815193_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012283852.1\|2815261_2816836_-	recombinase family protein	A0A2K5B2B4	Erysipelothrix_phage	4.7e-172	59.6
WP_041313979.1\|2816783_2817617_-	recombinase zinc beta ribbon domain-containing protein	NA	NA	NA	NA
WP_041315623.1\|2817617_2819192_-	recombinase family protein	A0A2K5B2B2	Erysipelothrix_phage	1.2e-143	49.6
WP_041315625.1\|2819252_2819435_-	hypothetical protein	NA	NA	NA	NA
WP_012283857.1\|2819572_2820295_-	N-acetylmuramoyl-L-alanine amidase	H7BVK7	unidentified_phage	1.2e-48	46.9
WP_012283858.1\|2820295_2820709_-\|holin	phage holin family protein	A0A2K5B2A2	Erysipelothrix_phage	1.7e-49	69.9
WP_012283859.1\|2820796_2823265_-	glycosyl hydrolase	A0A2K5B2A1	Erysipelothrix_phage	0.0e+00	68.5
WP_041313982.1\|2823261_2823846_-	hypothetical protein	A0A2K5B2A0	Erysipelothrix_phage	3.0e-55	55.7
WP_041315627.1\|2824291_2824486_-	hypothetical protein	A0A2K5B299	Erysipelothrix_phage	3.9e-20	69.2
WP_012283861.1\|2824501_2827024_-\|tail	phage tail protein	A0A2K5B298	Erysipelothrix_phage	0.0e+00	64.3
WP_012283862.1\|2827061_2827835_-\|tail	phage tail family protein	A0A2I4R672	Erysipelothrix_phage	2.5e-73	52.7
WP_012283863.1\|2827848_2830137_-	hypothetical protein	A0A2K5B297	Erysipelothrix_phage	2.7e-14	44.2
WP_012283864.1\|2830352_2830736_-	hypothetical protein	A0A2K5B295	Erysipelothrix_phage	1.2e-39	67.2
WP_012283865.1\|2830735_2831335_-\|tail	phage tail protein	A0A2K5B294	Erysipelothrix_phage	1.5e-81	75.3
WP_012283866.1\|2831340_2831685_-	hypothetical protein	A0A2K5B293	Erysipelothrix_phage	1.5e-30	55.9
WP_012283867.1\|2831681_2832113_-	HK97 gp10 family phage protein	A0A2K5B292	Erysipelothrix_phage	9.3e-46	63.6
WP_012283868.1\|2832099_2832441_-\|head,tail	head-tail adaptor protein	A0A2K5B291	Erysipelothrix_phage	5.7e-30	57.1
WP_012283869.1\|2832444_2832753_-\|head,tail	phage gp6-like head-tail connector protein	A0A2K5B290	Erysipelothrix_phage	2.8e-36	71.6
WP_012283870.1\|2832774_2833971_-\|capsid	phage major capsid protein	A0A2I4R671	Erysipelothrix_phage	1.4e-176	77.9
WP_041315628.1\|2833984_2834692_-\|protease	ATP-dependent Clp protease proteolytic subunit	Q6DMU1	Streptococcus_phage	3.4e-77	66.5
WP_012283872.1\|2834723_2835995_-\|portal	phage portal protein	A0A2K5B287	Erysipelothrix_phage	2.6e-184	75.7
WP_041313988.1\|2835991_2837593_-\|terminase	terminase large subunit	A0A2K5B285	Erysipelothrix_phage	4.7e-252	78.4
WP_012283874.1\|2837704_2838172_-	gamma-glutamylcyclotransferase	NA	NA	NA	NA
WP_041313991.1\|2838231_2839131_-	amidoligase family protein	A0A2K9V489	Faecalibacterium_phage	5.3e-51	40.4
WP_012283877.1\|2839272_2839503_-	DUF4314 domain-containing protein	E4ZFL7	Streptococcus_phage	2.6e-10	51.6
WP_012283878.1\|2839506_2839836_-	hypothetical protein	NA	NA	NA	NA
WP_012283879.1\|2839828_2840503_-	virulence factor	A0A2K5B280	Erysipelothrix_phage	8.0e-28	33.6
WP_012283880.1\|2840621_2841875_-	DNA modification methylase	A0A2I4R670	Erysipelothrix_phage	6.8e-97	45.7
WP_012283881.1\|2841880_2843179_-	DNA modification methylase	A0A2I4R670	Erysipelothrix_phage	1.1e-76	40.5
WP_041313994.1\|2843180_2843732_-\|terminase	terminase	A0A2K5B277	Erysipelothrix_phage	2.2e-71	69.8
WP_041313997.1\|2843879_2844239_-	HNH endonuclease	A0A2K5B276	Erysipelothrix_phage	3.0e-42	65.5
WP_049754186.1\|2844372_2844825_-	hypothetical protein	NA	NA	NA	NA
WP_012283886.1\|2845440_2847942_-	primase	A0A1B1P7L5	Bacillus_phage	1.6e-41	32.2
WP_012283887.1\|2847928_2848363_-	hypothetical protein	A0A2K5B270	Erysipelothrix_phage	2.8e-42	58.2
WP_012283888.1\|2848359_2850297_-	bifunctional 3'-5' exonuclease/DNA polymerase	S5M8J1	Bacillus_phage	5.3e-40	28.9
WP_012283889.1\|2850364_2851132_-	hypothetical protein	I3VYY1	Thermoanaerobacterium_phage	2.7e-48	43.9
WP_012283890.1\|2851153_2851576_-	hypothetical protein	I3VYY4	Thermoanaerobacterium_phage	3.3e-35	57.8
WP_083765288.1\|2851572_2853009_-	DEAD/DEAH box helicase	I3VYY6	Thermoanaerobacterium_phage	3.4e-124	50.1
WP_012283892.1\|2852998_2853190_-	hypothetical protein	NA	NA	NA	NA
WP_012283893.1\|2853269_2853668_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_012283897.1\|2854406_2856623_-	DUF5301 domain-containing protein	NA	NA	NA	NA
WP_012283898.1\|2856622_2856991_-	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_041315636.1\|2857159_2857762_-	hypothetical protein	NA	NA	NA	NA
WP_012281426.1\|2858035_2859397_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_9

2881062 : 2934377

Erysipelothrix_phage(83.33%)

portal,transposase,protease,holin,capsid,head,tail,terminase,integrase

attL 2870832:2870848|attR 2946120:2946136

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2870832:2870848	attL	NA	NA	NA	NA
WP_012283919.1\|2881062_2881281_-	helix-turn-helix transcriptional regulator	A0A2K5B261	Erysipelothrix_phage	4.1e-10	48.5
WP_148207143.1\|2881549_2881759_+	hypothetical protein	NA	NA	NA	NA
WP_148207144.1\|2881878_2882391_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_012283921.1\|2882537_2882720_+	hypothetical protein	NA	NA	NA	NA
WP_012283922.1\|2882703_2883036_+	hypothetical protein	A0A2K5B2A7	Erysipelothrix_phage	3.5e-08	37.3
WP_012283923.1\|2883028_2884150_+	DUF2800 domain-containing protein	A0A1X9I6D8	Streptococcus_phage	1.4e-125	58.3
WP_012283924.1\|2884163_2884742_+	DUF2815 family protein	E4ZFK3	Streptococcus_phage	1.7e-74	73.0
WP_012283925.1\|2884738_2886679_+	DNA polymerase	A0A2K5B2B0	Erysipelothrix_phage	4.1e-282	71.7
WP_012283926.1\|2886759_2886966_+	hypothetical protein	A0A2K5B269	Erysipelothrix_phage	3.9e-18	55.9
WP_012283927.1\|2886962_2887631_+	Rha family transcriptional regulator	A0A2K5B268	Erysipelothrix_phage	9.2e-101	80.6
WP_041314019.1\|2887646_2888072_+	hypothetical protein	A0A2K5B270	Erysipelothrix_phage	4.3e-43	58.2
WP_012283930.1\|2888068_2890456_+	virulence-associated protein E	A0A2K5B271	Erysipelothrix_phage	4.3e-209	48.6
WP_012283931.1\|2890621_2890903_+	VRR-NUC domain-containing protein	A0A2K5B272	Erysipelothrix_phage	1.2e-25	64.4
WP_012283932.1\|2890883_2892242_+	DEAD/DEAH box helicase	A0A2K5B273	Erysipelothrix_phage	9.1e-172	73.6
WP_012283933.1\|2892238_2892688_+	hypothetical protein	NA	NA	NA	NA
WP_041314022.1\|2892815_2893172_+	HNH endonuclease	A0A2K5B276	Erysipelothrix_phage	2.3e-42	64.7
WP_012283934.1\|2893287_2893866_+\|terminase	terminase	A0A2K5B277	Erysipelothrix_phage	6.6e-47	50.8
WP_012283935.1\|2893872_2895105_+	site-specific DNA-methyltransferase	A0A2I4R670	Erysipelothrix_phage	1.1e-144	61.9
WP_012283936.1\|2895097_2897101_+	DNA cytosine methyltransferase	A0A2K9V3X0	Faecalibacterium_phage	8.5e-33	60.0
WP_012283937.1\|2897191_2897860_+	hypothetical protein	A0A2K5B280	Erysipelothrix_phage	2.0e-50	49.1
WP_041314026.1\|2897852_2898077_+	DUF4314 domain-containing protein	A0A2K5B281	Erysipelothrix_phage	3.0e-11	56.7
WP_012281187.1\|2898276_2899899_-\|transposase	IS1182-like element ISHmo2 family transposase	NA	NA	NA	NA
WP_041314029.1\|2900149_2900524_+	amidoligase family protein	NA	NA	NA	NA
WP_012281343.1\|2900562_2901588_-\|integrase	site-specific integrase	S5M872	Bacillus_phage	1.4e-07	23.9
WP_148207041.1\|2901584_2902574_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012281345.1\|2902570_2903794_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012283940.1\|2904611_2905076_+	gamma-glutamylcyclotransferase	G3MAQ5	Bacillus_virus	2.0e-17	36.0
WP_041314032.1\|2905068_2905254_+	DUF5049 domain-containing protein	NA	NA	NA	NA
WP_041315645.1\|2905343_2906945_+\|terminase	terminase large subunit	A0A2K5B285	Erysipelothrix_phage	1.6e-263	83.1
WP_012283943.1\|2906941_2908201_+\|portal	phage portal protein	A0A2K5B287	Erysipelothrix_phage	6.5e-180	73.5
WP_012283944.1\|2908197_2908911_+\|protease	Clp protease ClpP	Q6DMU1	Streptococcus_phage	9.3e-75	66.7
WP_012283945.1\|2908931_2910131_+\|capsid	phage major capsid protein	A0A2I4R671	Erysipelothrix_phage	9.2e-184	80.1
WP_012283946.1\|2910150_2910471_+\|head,tail	phage gp6-like head-tail connector protein	A0A2K5B290	Erysipelothrix_phage	1.9e-40	82.0
WP_012283947.1\|2910473_2910806_+\|head,tail	head-tail adaptor protein	A0A2K5B291	Erysipelothrix_phage	7.2e-30	58.5
WP_012283948.1\|2910798_2911230_+	HK97 gp10 family phage protein	A0A2K5B292	Erysipelothrix_phage	3.2e-46	65.0
WP_012283949.1\|2911226_2911571_+	hypothetical protein	A0A2K5B293	Erysipelothrix_phage	6.7e-31	54.1
WP_012283950.1\|2911573_2912164_+\|tail	phage tail protein	A0A2K5B294	Erysipelothrix_phage	5.3e-76	73.6
WP_012283951.1\|2912178_2912562_+	hypothetical protein	A0A2K5B295	Erysipelothrix_phage	2.4e-45	72.2
WP_012283953.1\|2912835_2915394_+	hypothetical protein	A0A2K5B297	Erysipelothrix_phage	6.0e-23	80.0
WP_012283954.1\|2915407_2916181_+\|tail	phage tail family protein	A0A2I4R672	Erysipelothrix_phage	5.0e-74	52.7
WP_012283955.1\|2916185_2918705_+\|tail	phage tail protein	A0A2K5B298	Erysipelothrix_phage	5.6e-311	61.6
WP_012283956.1\|2918717_2918912_+	hypothetical protein	A0A2K5B299	Erysipelothrix_phage	7.9e-13	53.8
WP_041314035.1\|2918921_2919491_+	hypothetical protein	A0A2K5B2A0	Erysipelothrix_phage	5.9e-48	51.4
WP_012283958.1\|2919487_2921956_+	glycosyl hydrolase	A0A2K5B2A1	Erysipelothrix_phage	0.0e+00	66.9
WP_012283959.1\|2922034_2922466_+\|holin	phage holin family protein	A0A2K5B2A2	Erysipelothrix_phage	3.4e-48	68.1
WP_012283960.1\|2922936_2923635_+	N-acetylmuramoyl-L-alanine amidase	H7BVK7	unidentified_phage	2.9e-49	43.4
WP_012283961.1\|2923783_2924005_+	hypothetical protein	A0A2K5B2B1	Erysipelothrix_phage	2.3e-08	51.9
WP_012283962.1\|2924055_2925618_+	recombinase family protein	A0A2K5B2B2	Erysipelothrix_phage	7.6e-154	52.8
WP_012283963.1\|2925618_2926050_+	hypothetical protein	A0A2K5B2B3	Erysipelothrix_phage	1.8e-25	45.3
WP_012283964.1\|2926036_2927605_+	recombinase family protein	A0A2K5B2B4	Erysipelothrix_phage	2.4e-160	56.9
WP_041314041.1\|2927674_2927998_-	hypothetical protein	NA	NA	NA	NA
WP_012283966.1\|2928000_2928684_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_012283967.1\|2929097_2930570_-	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	2.9e-62	32.0
WP_012283968.1\|2930755_2932018_+	hypothetical protein	NA	NA	NA	NA
WP_041314044.1\|2932059_2933706_-	amidohydrolase family protein	NA	NA	NA	NA
WP_083765254.1\|2933702_2934377_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
2946120:2946136	attR	NA	NA	NA	NA

DBSCAN-SWA_10

3053528 : 3066397

Synechococcus_phage(20.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012284075.1\|3053528_3054386_+	chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	4.3e-10	42.9
WP_041315690.1\|3054608_3055016_-	CBS domain-containing protein	A0A2I6B2H4	Macacine_betaherpesvirus	1.3e-09	33.6
WP_041314082.1\|3055189_3056485_-	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
WP_012284078.1\|3056521_3058105_-	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	1.5e-77	50.8
WP_012284079.1\|3058238_3058844_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.5e-28	38.2
WP_012284080.1\|3058840_3059941_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FK46	Synechococcus_phage	3.7e-70	44.7
WP_012284081.1\|3059950_3061396_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.1e-65	36.6
WP_012284082.1\|3061418_3061757_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_041315691.1\|3061760_3062477_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SSV5	Cyanophage	9.4e-43	40.3
WP_012284084.1\|3062612_3063905_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	2.2e-21	32.6
WP_012284086.1\|3064192_3064708_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	5.2e-27	48.4
WP_012284087.1\|3065032_3066397_-	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	4.9e-48	31.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_010337

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection