CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_010571	Opitutus terrae PB90-1, complete sequence	5 crisprs	Cas9_archaeal,csa3,WYL,DinG	0	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_010571_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010571_1

940221-940291

Orphan

Consensus_repeat	Method
ACGGGCGGGACGCCCGTGCCACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010571_1

>merge|NC_010571|1|940221-940291|CRISPRCasFinder
ACGGGCGGGACGCCCGTGCCACGGCTCATGCCCGCTTGCGCCAATCCTACGGGCGGGACGCCCGTGCCACG

>NC_010571|1|1|940221-940291|CRISPRCasFinder
ACGGGCGGGACGCCCGTGCCACG	GCTCATGCCCGCTTGCGCCAATCCT
ACGGGCGGGACGCCCGTGCCACG

Protein	Signature genes	Signature genes Name	Protein_function
NC_010571.1\|WP_012373601.1\|943142_944243_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_010571.1\|WP_012373600.1\|942569_943025_+\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|238245
NC_010571.1\|WP_012373597.1\|937965_938832_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|336409
NC_010571.1\|WP_012373594.1\|935485_935872_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|366361
NC_010571.1\|WP_012373593.1\|934075_935227_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NC_010571.1\|WP_012373595.1\|936331_937153_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293807
NC_010571.1\|WP_012373605.1\|951453_953718_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|274362
NC_010571.1\|WP_012373599.1\|941429_942413_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223566
NC_010571.1\|WP_012373606.1\|953883_954675_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234723
NC_010571.1\|WP_012373602.1\|944250_948930_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|274362
NC_010571.1\|WP_083767606.1\|955645_956302_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235513
NC_010571.1\|WP_012373603.1\|948926_950864_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_010571.1\|WP_148217997.1\|937468_937756_+\|hypothetical-protein	unknown	unknown	unknown
NC_010571.1\|WP_012373589.1\|931469_932081_-\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225462
NC_010571.1\|WP_012373592.1\|933365_933956_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_010571.1\|WP_012373591.1\|932889_933264_-\|hypothetical-protein	unknown	unknown	unknown
NC_010571.1\|WP_012373590.1\|932100_932736_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|334450
NC_010571.1\|WP_158305353.1\|950884_951451_+\|DUF4154-domain-containing-protein	unknown	unknown	gnl\|CDD\|379335
NC_010571.1\|WP_012373607.1\|954843_955617_+\|pantoate--beta-alanine-ligase	unknown	unknown	gnl\|CDD\|376824
NC_010571.1\|WP_012373588.1\|931197_931362_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_010571.1\|WP_012373601.1\|943142_944243_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.3587e-28
NC_010571.1\|WP_012373606.1\|953883_954675_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl\|CDD\|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	3.82956e-139
NC_010571.1\|WP_012373597.1\|937965_938832_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|336409	pfam06445, GyrI-like, GyrI-like small molecule binding domain. This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.	6.85362e-50
NC_010571.1\|WP_012373594.1\|935485_935872_-\|VOC-family-protein	gnl\|CDD\|366361	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	8.91981e-11
NC_010571.1\|WP_012373593.1\|934075_935227_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	1.82412e-146
NC_010571.1\|WP_012373595.1\|936331_937153_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	2.71925e-67
NC_010571.1\|WP_012373605.1\|951453_953718_+\|PAS-domain-S-box-protein	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	3.83554e-56
NC_010571.1\|WP_012373599.1\|941429_942413_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	2.12383e-41
NC_010571.1\|WP_012373602.1\|944250_948930_+\|PAS-domain-S-box-protein	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	3.06044e-57
NC_010571.1\|WP_083767606.1\|955645_956302_+\|hypothetical-protein	gnl\|CDD\|235513	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated.	2.03531e-72
NC_010571.1\|WP_012373603.1\|948926_950864_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	4.35418e-43
NC_010571.1\|WP_012373589.1\|931469_932081_-\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|225462	COG2910, COG2910, Putative NADH-flavin reductase [General function prediction only].	3.23976e-89
NC_010571.1\|WP_012373592.1\|933365_933956_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.1055e-11
NC_010571.1\|WP_012373600.1\|942569_943025_+\|cysteine-hydrolase	gnl\|CDD\|238245	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.	6.0551e-20
NC_010571.1\|WP_012373590.1\|932100_932736_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|334450	pfam01243, Putative_PNPOx, Pyridoxamine 5'-phosphate oxidase. Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as yeast YLR456W and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.	3.72975e-12
NC_010571.1\|WP_012373607.1\|954843_955617_+\|pantoate--beta-alanine-ligase	gnl\|CDD\|376824	pfam02569, Pantoate_ligase, Pantoate-beta-alanine ligase. Pantoate-beta-alanine ligase, also know as pantothenate synthase, (EC:6.3.2.1) catalyzes the formation of pantothenate from pantoate and alanine.	3.73802e-125
NC_010571.1\|WP_158305353.1\|950884_951451_+\|DUF4154-domain-containing-protein	gnl\|CDD\|379335	pfam13689, DUF4154, Domain of unknown function (DUF4154). This family of proteins is found in bacteria. Proteins in this family are typically between 172 and 207 amino acids in length. Many members are annotated as valyl-tRNA synthetase but this could not be confirmed.	6.14939e-46

>NC_010571.1|WP_012373597.1|937965_938832_-|AraC-family-transcriptional-regulator
MTSVRPATEQDYQERLRRVLLHIDQHRAAPLCLDDLAAVACLSPFHFHRIFRAYVGEPVGRYVQRIRLETAAVQLQTTQRSVTDIALDAGYESAAGFSRAFEERFGMAPTECRKTHQLSLQVRTASLQPSQPNAMIAPEIRERPDTRVAFVRHVGPYAAVGAAWARICGFAAAHQLFGPTTAMIGIGWDDPKLTAEDRIRYDACLTVNEKFVPSREVSVQTIPGGRYAVFLHAGPYHQLITTYDAIFRDWLPRSGEQLREQPAFELYLNSPDRTPPADLRTEIWVPLQ
>NC_010571.1|WP_148217997.1|937468_937756_+|hypothetical-protein
MPADTSKPAAARMLQPATRAFEGEMRTCSRYGFPTWSWVDSAASRERLVKIRFLFQPAAPLRDELVRAPPVPERHAQQEQMTGARRADVDRPLAR
>NC_010571.1|WP_012373595.1|936331_937153_-|MBL-fold-metallo-hydrolase
MRPSPTFHVAGGVAGLRTLMVNVYFVASGSEPGVWMLVDGGLRGAGPRILREAERHFGTGVPPRAIVLTHGHFDHVGGLPWLLQRWQVPVFAHPNELRFVNGQRPYAPADPSVGGGVMTLSSPLYPRHPAKLPVAVHALPEHGAVPGLPEWEWIATPGHSPGHVSLWRAHDRLLISGDAVISTRQESALAVWRQTREVRPPPAYFTHDWPAAYRSMLRLRQLNPAVLASGHGQPLSGESWLRELDQLLADFPHRGLPPRGRYVPSEWTERAVA
>NC_010571.1|WP_012373594.1|935485_935872_-|VOC-family-protein
MKFEHFALNVPDVRAMAGWYVEHLGFAIARSRADAPFTHFLKDETGRVIVELYTNPAAAIPDYRAAHPLCFHIAVVAADARAERARLQKAGATFEAQDLLPDGSILFMLRDPWGVPLQLCQRVQPLGG
>NC_010571.1|WP_012373593.1|934075_935227_-|PLP-dependent-aminotransferase-family-protein
MQQLRPSTIREILKVTAQPEVISFAGGLPAPELFPVEAVSRAAQAVLADGGSNALQYSESEGYGPLREWIATEMARRGVRASAQDVLVTTGSQQVLDLAGKAFLDPGDVVLTENPTYLAAIQAFQAMEARFVPVPTDAIGLVPEEIPALIAQHRPKFLYTIPNFQNPTGVTLPADRREKLARIAAEHGLTILEDDPYGQLRYRGSDVPPVKHWDTAGRVLYASTFSKIIAPGLRTGWVVAPHEVFLKLLMLKQASDLHTSSFDQRVAHVYLTSGDPMAHVAKIRAAYGERFGVMDAALREEMPKGFSWTHPEGGMFLWITGPKELDALALLEKAVQRKVAFVPGRDFFPGDAGRNYLRLNFSNSTPERIREGVHRLAALCRER
>NC_010571.1|WP_012373592.1|933365_933956_+|TetR/AcrR-family-transcriptional-regulator
MSSTASPAPASTPKRDRLLDVANRLFYRQGYHATGIDTILAEAELAKMTLYHHFASKEELIVAALERRSQAIGGALAAAMQAAGSSPRKRLQALFDWHAEWFADRQFNGCAFMRAVGEYPELKSPVHQAVRKHKQASRARLEQLLSEMKLPGAAALAQQIQLLLEGAIAIAHTEGDPASIEAARTAAFELIKAAER
>NC_010571.1|WP_012373591.1|932889_933264_-|hypothetical-protein
MKNAIIILSDPRAGSDEATSRLLNALAFADECQRNADELEIVFAGTGTRWPQELAKPTHPAHTRYSALREHVRGASRSCAVRNDAVPGLEAVGVPLIADNLVPGSQGVASLRRYVADGWHVTTF
>NC_010571.1|WP_012373590.1|932100_932736_-|pyridoxamine-5'-phosphate-oxidase-family-protein
MRREFLRTLATPTVQAAQARYYGTSRVPAPGPVTQSLGSEEQAFIAARDSFYLATVSENGWPYVQHRGGPKGFLRVVGPAQLAFADYNGNRQLLTTGNVQAHRRVALFLMDYAARERLKILGHARVLPATEAGEWIPQLAVPPRTVVERVFLIDVVGFDWNCPKYITPRFTAEEVTAMTAPLRERIAELERALAERRSAQGSVVAARLPET
>NC_010571.1|WP_012373589.1|931469_932081_-|NAD(P)-dependent-oxidoreductase
MKIAILGATGRVGSHLLAEALSRGHTVTGLARHPEALAAQPRLRAQRVDANEPEQLAAATAGHEALLSAVHFTDLKASTLLSAVKRSAVPRLLVVGGAGSLEVAPGESLVDTPEFPADYKAEALAARDFLQELRKETDVDWTFLSPSAFLHDGPRTGKFRLGDDTLLVDAQGQSAISIADYAIALIDELERPRHSRRRFTVGY
>NC_010571.1|WP_012373588.1|931197_931362_-|hypothetical-protein
MNKLCTLGGAVVGGYAGWFLAEALGAGFWVMFCVSSVGSLVGVYLGWKVARRFE
>NC_010571.1|WP_012373599.1|941429_942413_-|NAD(P)/FAD-dependent-oxidoreductase
MLRCQQRERSTAAPRSPGDIVATDSGELHDVCIVGAGPAGLNAALILGRCRRDVVVIDSGKPRNGASRALHGFLSRDGTPPLELRALGRAELEPYPSVQLRQNTAVVAARRGENRFDLTLADGSTVAARILLLATGRIDLVPEKPGFREYYGLGVFHCPYCDGWEHRDETLVAYSSGETGHDLALDLRVWSRDVVLCTDGPSGLTPAQLRKLALNGVRVIEAPVVGARGGTGGVIASIVFEGHPELSCGAIFFSSDCLQKSPLAEELGCDLDDTGSVRCTGHAATQVPGLYVAGNVRGGVHLAIVAAAEGAEAGMAINNALHEADLK
>NC_010571.1|WP_012373600.1|942569_943025_+|cysteine-hydrolase
MDAIIIVDLQQDLPVPPELVRRIEARSREFPRRVFTKFINEPGSLFRTKLGRNSCLPGTPGAELTLPTTDADLVLEKPGYGLGPMQIAQIRAAGIQKALVCGVDTDACVLGVVFSLFDAGIDCEVDRELCWSSSGLHEAALKIVQEQFGTG
>NC_010571.1|WP_012373601.1|943142_944243_+|HAMP-domain-containing-histidine-kinase
MNLPMASLLPTSVLCIGADAAGADLLAVTTRRLADGVAVRSYARLADVPPDAAVDGAGLLALCDPDAATLREALAAKDHAALPRWAVLVLGAMPDTETDGTLAVAREEWAPAVLAHAMRGALALHRCRREHAQLCGDVATFGSRIAHDLRTPLGGVMTTTEMLHEILMESDPDNAALTQPILDSADGLVKLIERMSFLAKAIASREPPQRVDMGVPFWNAFQQLESRLLATHTPLTYPQEWPAVHGHSTWLQVVWRELIANAVQHGSPGAPIEAGWNPVAGGFRFWVQDHGRVAPSLRPVLFMPFHRLNEPGAPRGLGLAIVQRLIAAEGGTCSYEPTRDGESCFTFTLPAASPSDSVSSSTTTLG
>NC_010571.1|WP_012373602.1|944250_948930_+|PAS-domain-S-box-protein
MADASDKTAGQSGPTCAADPFRGGGEAGAILRAIDWPSKPIGPVDTWPQSLRTALSLCLASRHPICIIWGPDRLYFYNDAYAPILGEKHPWALGESYITVWPEIWESSIRPILEQVEQTGEASWCDDLLLVLRRHGFNEECYFAFSFAPTRVEDGSVGGVFTAITETTLQVVGERRLHTLRDLGARAPDARSAEEACRIAADVLAQNRYDVPFALFYAIDETGQAAKLVPGPGIEPGARGTPARVALDQEDPEDFWHFGEVIRSGKPRVHSQLPEDLGPLPKGPWPERPHTAVVLPIARPGESVPYGLLVCGASARRPLDPDYQSFFSLIASQVATAVANALAFAEQRRRAESLAALDRAKIDFFSNVSHEFRTPLTLILGPLEELLSEPARSALPADAREQLKVVHRNSLRLLKLVNMLLDFSRLEAGRIDAHFEPVDLPEFTADLVAVFRSAIEKAGLRLQVDCPPAPFPALVDREMWEKIVFNLLSNAFKFTRHGEIEVSLHCLGPTFELRVRDTGLGIPPESQSEVFKRFHRLKHAHSRTHEGTGIGLSLVQELVRLHGGTVSLTSEVNVGTIVSVTIPVHRPAGTPANPGAPRSASGVEPRAFVEESLRWIQPTDAVMKAPAVPRADRPPLARVLLADDNADMRDYVMRLLREHYDIAAVADGQAALALVRHWKPDLVLADIMMPGLDGFELLQALRESPATQQLPVILLSARAGEESRSEGLEAGADDYLIKPFSARELLARVQSQLHLAELRRKAEAKVTASEARLAQLVAMLPAGIYTVDAEGRITFYNPRAAEIWQARPTLHAPYAEFAAQFKIIGEDGREVAMETRPMPTVLREGRNLVTNEIELERPDGSRFFANFSISPTFGPDGQISGAIAVFQDVTAERQARVALRATEERYRAVFQQASIGIMECDLEGRILRCNPALARLVGYAEAELCGMNWRDLCPPEEVGENERVAQRLLRGDRPSFTGERRYRRKDGSVGWIDIFATSIFDDSGRPTYGLAMLVDITERKRAEAELRETEERFRVAADNAPVLLWIADTDKQRTWFNQPWLEFVGRTLEQEVGLGWLDNVHPEDRDHVLEVFDTAFERRGPFRLEYRIRRHDGEYRWMLVHGVPRQQDEEFVGYIGSCVDITDRRLAEEAIHASRNAERAHRVELERARDEAVAASRAKDDFLAALSHELRTPLSPVLLLASDAAADPQLPPSVRADFETIRKSVELEARLIDDLLDLTRIVRDKISLDLREVDAPVALRDALINVRAEFEAKRIGLVLDLSPEPQFVRADPVRLQQVIWNVLKNAVKFTPAGGRVTITSRIDHERRRLVLAVADTGIGMTAGEIERAFEAFAQGDHAGSGGSHRFGGLGLGLAISRRVVELHGGSITAQSPGRGRGAVFRIELPLLAGPAGATAGDPPVAWELPTDRTTAAATGGSRRRVLLVEDHAPTRSALESLLVRRGFSVTAAASATEARALAASEHFDLLISDIGLPDGSGYDLMAEFRERYGLVGIALTGYGMEEDVMRSRRAGFKMHLTKPVRIQHLDQALATLQAAKEGE
>NC_010571.1|WP_012373603.1|948926_950864_+|TonB-dependent-receptor
MNRRRSRARRWIPGLRGLAVAGLCHVAAAHAQTPLASAERMQQLSLEELLSLEVTTMSRKTEPWWTAPGAVEVLTSEEIRRSTARNLPEALRLATGLDVAQSSARSWAISARGFNVLAANKISVLLDGRSLFTPFFSGVQWDAQDTLLADVDRIEVVRGPVGALWGAFAVNGFVQIVTKPADDTQGWLVSGGAGTEDPGFLAVRYGGRIGRRAFYRVYAKYFDTDWTYLANGRHAQPSTDFGQVGFRADALLDADTSLTVQGDAYTNKGLPQDREQAEISGGNLLARIRRTFSAASDLEVMSYYDRTARWLPTAWLERRDTGALTAKFRYPLDRHDLLVGADVHVSRDDIANLGFATMVPPQRTTHVVGVYLQDTIAVVPRRWAVTLGAKAEHNSFSGVEAEPSLRAAWTPTPRTTGWAAVSRAVRAPVRVDQDLLLQLGGQIIVDASDAFDSESVVAYELGWRQQVGSQLTLDVAAFHNEYRDLRTAEPIGAEIFPLTFKNGAEAQADGLETSVQYQPSARLFFKASYRLLDLDFMLRPGSRAGSSFANEGNDPRHLGSLTAHAVLSHHLEFDATLRHVSSRPDPATEGYWTADLRLAWLPSESWEIALLGRNLFTGLHRELITTNSLNEFIRASGTVKITWRY
>NC_010571.1|WP_158305353.1|950884_951451_+|DUF4154-domain-containing-protein
MPAVRLSRLLRAACAGLWLSLSAPGVRAVPAADEAAVKAALLYNLTQFVDWPPSSFRTPYDPVIIGILGPDPFDDYLDQLVRPVGAGSRRVVVMRFRDARAARQAHVLFIHASQREHLQAIFATLEGRAVLTVADFDGFLRRGGIVRFYRNAENKIRVRINLEAARAAGLTISAKLLRVVEIVPPEEE
>NC_010571.1|WP_012373605.1|951453_953718_+|PAS-domain-S-box-protein
MDFRDLPIKRKLAGAIMLTSLTVLALTSLALITYELYAYKQTTRRTLSTIADIIASNSTAVLIYDDHKLASQILAGLHDEPEIEAAALYDKDGQLYVSYPLSLGPTGVPATPGVDGIDFGLRQITLFEPVIEGQNRVGTLYLRGDLADMYRRLGVYGLVLLSVLGCSGLVALSLAAYFQRLISQPILNLANTARIVSERKDYSVRAVKLSNDELGGFTETFNSMLHQVQESHSALRESEERLSAVFQQAGAGIAQTDVSGRFLMVNDRYCEIVGRPRESLLQLRMQDIIHPADLSHHQFLSEHSARDGSSFVVETRYDRPQGGFVWVRNSVAFIRDAAGTIESAIAVTEDITSSKRTEKELERARDDALAASRAKDDFLATLSHELRTPLNPVLLLASEAAEDPTLPPAVRSDFATIRNNVELEARLIDDLLDLTRITRGKLLLDLKPHDMHAILQDALATVRAELERKQIVTTLKFDAGRAVVLSDAVRLQQVFWNVLKNAVKFTPEQGGITVHTHLAVGDSLVVEITDTGIGLEPAEIERIFDAFSQGDHAGTAGSHRFGGVGLGLAISRMLVELHRGSIRAESPGRGHGATFRIELPLLRRDVAAPRMPAADGPPARAAAAAGSAVPETMRRRILLVEDHAPTRTTLQQLLMRRRYEVLAAGTVAEARAIAAKESFDFVISDIGLPDGNAYELMSDLRAEKGLTGIALTGYGMESDIARSHAAGFVVHLTKPLRVQSLDEALARISGATPA
>NC_010571.1|WP_012373606.1|953883_954675_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MPTIRDLAAAKAGGRKIVMVTAYDASAARLLAGTEVDCLLVGDSAMMVVHGQRDTLGATVELMAMHTRAVVRGAPGKLIVTDFPFLAARKGIAPALDAAAELLRAGAHAVKIEGVRGHANVIRHLIESGIPVMGHLGLQPQSVHTLGGYTVQGRDPVEAQRLHEDAAELQALGVFALVLECVPQKLARNVTAELQIPTIGIGAGAGCDGQVLVWHDLLGLNPDFKPKFVRPFADGATVLREGINRFVTAVRAGKFPTNKESFS
>NC_010571.1|WP_012373607.1|954843_955617_+|pantoate--beta-alanine-ligase
MPKLIHTIAEWRALRAEHRAAGRTIGFVPTMGALHEGHASLFRAAAGEHPVVLASVFVNPTQFDEQHDFEKYPRTLAADCALMDAAGVTVAFVPSVDEMYPNGTRYGVVETEFSRELCGAHRPGHFAGMLTVVMKLLQIADAEAAYFGEKDYQQLLLIRGMREAFFLPTRIVGCPIIREPDGLAMSSRNARLSSAERALAPQFHSALVAAPTVEQARARLEAAGFRVDYVEDRDGRRFGAVRLGQTRLIDNVSLRVE
>NC_010571.1|WP_083767606.1|955645_956302_+|hypothetical-protein
MPPPSRTRLRAGLLRPSTLNPQLSSRFSAPMPNVLVLLTGSIACFKACTLISRLVQAGVTVQTVATPAALRFVGTATLEGLSGRPVFTDVFEEGRALDHIALARAADLALVCPATANTINQLAAGIAGDPVGTLFLAWELESKPWWIAPAMNAWMWKHPATAASIATLKSWGVRVLDPVEGPHACGETGPGRLAEPELITAEILKTLGARPPSAASEM

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Crispr_ID: NC_010571_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010571_2

3307819-3307908

Orphan

Consensus_repeat	Method
GGCGAAAGCCTCACGGCTTCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010571_2

>merge|NC_010571|2|3307819-3307908|CRISPRCasFinder
GGCGAAAGCCTCACGGCTTCCGCTACCAAGCGCGTCGAGGGCAACGCGCTCCACCTGACGCCGGTTGGGCGAAAGCCTCACGGCTTCCGC

>NC_010571|2|2|3307819-3307908|CRISPRCasFinder
GGCGAAAGCCTCACGGCTTCCGC	TACCAAGCGCGTCGAGGGCAACGCGCTCCACCTGACGCCGGTTG
GGCGAAAGCCTCACGGCTTCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_010571.1\|WP_012375398.1\|3313348_3314659_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NC_010571.1\|WP_012375399.1\|3314733_3316764_-\|hypothetical-protein	unknown	unknown	unknown
NC_010571.1\|WP_012375386.1\|3304419_3304962_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NC_010571.1\|WP_012375390.1\|3307296_3307719_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NC_010571.1\|WP_044892482.1\|3316787_3317357_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274618
NC_010571.1\|WP_012375396.1\|3312108_3312564_-\|phosphoribosyl-AMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234598
NC_010571.1\|WP_012375381.1\|3297514_3299140_-\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NC_010571.1\|WP_012375391.1\|3307987_3308641_+\|carbonate-dehydratase	unknown	unknown	gnl\|CDD\|238448
NC_010571.1\|WP_012375385.1\|3304063_3304438_-\|hypothetical-protein	unknown	unknown	unknown
NC_010571.1\|WP_012375383.1\|3300196_3301969_-\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|223097
NC_010571.1\|WP_012375395.1\|3311816_3312038_-\|hypothetical-protein	unknown	unknown	unknown
NC_010571.1\|WP_012375384.1\|3302614_3304000_+\|thymidine-phosphorylase	unknown	unknown	gnl\|CDD\|274244
NC_010571.1\|WP_044892481.1\|3305560_3306784_+\|class-I-SAM-dependent-rRNA-methyltransferase	unknown	unknown	gnl\|CDD\|224017
NC_010571.1\|WP_012375392.1\|3308798_3309356_-\|elongation-factor-P	unknown	unknown	gnl\|CDD\|234788
NC_010571.1\|WP_012375387.1\|3304983_3305442_-\|hypothetical-protein	unknown	unknown	unknown
NC_010571.1\|WP_012375382.1\|3299162_3299912_-\|DUF4339-domain-containing-protein	unknown	unknown	gnl\|CDD\|379517
NC_010571.1\|WP_012375397.1\|3312903_3313203_-\|DUF971-domain-containing-protein	unknown	unknown	gnl\|CDD\|377616
NC_010571.1\|WP_012375389.1\|3306886_3307252_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380355
NC_010571.1\|WP_012375394.1\|3310985_3311774_+\|acyl-ACP--UDP-N-acetylglucosamine-O-acyltransferase	unknown	unknown	gnl\|CDD\|100042
NC_010571.1\|WP_012375393.1\|3309564_3310905_+\|bifunctional-UDP-3-O-[3-hydroxymyristoyl]-N-acetylglucosamine-deacetylase/3-hydroxyacyl-ACP-dehydratase	unknown	unknown	gnl\|CDD\|237296

Protein	Function_ID	Function_description	E-value
NC_010571.1\|WP_012375386.1\|3304419_3304962_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	1.42011e-35
NC_010571.1\|WP_012375390.1\|3307296_3307719_+\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	2.75565e-17
NC_010571.1\|WP_044892482.1\|3316787_3317357_-\|hypothetical-protein	gnl\|CDD\|274618	TIGR03508, decahem_SO, decaheme c-type cytochrome, DmsE family. Members of this family are small, decaheme c-type cytochromes, related DmsE of Shewanella oneidensis MR-1, which has been shown to be part of an anaerobic dimethyl sulfoxide reductase.	1.86925e-38
NC_010571.1\|WP_012375396.1\|3312108_3312564_-\|phosphoribosyl-AMP-cyclohydrolase	gnl\|CDD\|234598	PRK00051, hisI, phosphoribosyl-AMP cyclohydrolase; Reviewed.	2.87725e-73
NC_010571.1\|WP_012375381.1\|3297514_3299140_-\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	1.0085e-27
NC_010571.1\|WP_012375391.1\|3307987_3308641_+\|carbonate-dehydratase	gnl\|CDD\|238448	cd00883, beta_CA_cladeA, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	1.10861e-108
NC_010571.1\|WP_012375398.1\|3313348_3314659_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	1.0109e-139
NC_010571.1\|WP_012375383.1\|3300196_3301969_-\|arginine--tRNA-ligase	gnl\|CDD\|223097	COG0018, ArgS, Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis].	0
NC_010571.1\|WP_012375384.1\|3302614_3304000_+\|thymidine-phosphorylase	gnl\|CDD\|274244	TIGR02644, Thymidine_phosphorylase, pyrimidine-nucleoside phosphorylase. In general, members of this protein family are designated pyrimidine-nucleoside phosphorylase, enzyme family EC 2.4.2.2, as in Bacillus subtilis, and more narrowly as the enzyme family EC 2.4.2.4, thymidine phosphorylase (alternate name: pyrimidine phosphorylase), as in Escherichia coli. The set of proteins encompassed by this model is designated subfamily rather than equivalog for this reason; the protein name from this model should be used when TIGR02643 does not score above trusted cutoff. [Purines, pyrimidines, nucleosides, and nucleotides, Other].	1.66023e-160
NC_010571.1\|WP_044892481.1\|3305560_3306784_+\|class-I-SAM-dependent-rRNA-methyltransferase	gnl\|CDD\|224017	COG1092, COG1092, Predicted SAM-dependent methyltransferases [General function prediction only].	5.27733e-107
NC_010571.1\|WP_012375392.1\|3308798_3309356_-\|elongation-factor-P	gnl\|CDD\|234788	PRK00529, PRK00529, elongation factor P; Validated.	2.92996e-89
NC_010571.1\|WP_012375382.1\|3299162_3299912_-\|DUF4339-domain-containing-protein	gnl\|CDD\|379517	pfam14237, DUF4339, Domain of unknown function (DUF4339). This domain is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. There are two completely conserved residues (G and W) that may be functionally important.	5.76576e-05
NC_010571.1\|WP_012375397.1\|3312903_3313203_-\|DUF971-domain-containing-protein	gnl\|CDD\|377616	pfam06155, DUF971, Protein of unknown function (DUF971). This family consists of several short bacterial proteins and one sequence from Oryza sativa. The function of this family is unknown.	1.68749e-22
NC_010571.1\|WP_012375389.1\|3306886_3307252_+\|cupin-domain-containing-protein	gnl\|CDD\|380355	cd02226, cupin_YdbB-like, Bacillus subtilis YdbB and related proteins, cupin domain. This family includes bacterial proteins homologous to YdbB, a Bacillus subtilis protein of unknown function. It also includes protein Nmb1881 From Neisseria meningitidis, also of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	4.18034e-50
NC_010571.1\|WP_012375394.1\|3310985_3311774_+\|acyl-ACP--UDP-N-acetylglucosamine-O-acyltransferase	gnl\|CDD\|100042	cd03351, LbH_UDP-GlcNAc_AT, UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic pathway and is also referred to as LpxA. Lipid A is essential for the growth of Escherichia coli and related bacteria. It is also essential for maintaining the integrity of the outer membrane. UDP-GlcNAc acyltransferase is a homotrimer of left-handed parallel beta helix (LbH) subunits. Each subunit contains an N-terminal LbH region with 9 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), and a C-terminal alpha-helical region.	2.01217e-126
NC_010571.1\|WP_012375393.1\|3309564_3310905_+\|bifunctional-UDP-3-O-[3-hydroxymyristoyl]-N-acetylglucosamine-deacetylase/3-hydroxyacyl-ACP-dehydratase	gnl\|CDD\|237296	PRK13188, PRK13188, bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed.	0

>NC_010571.1|WP_012375390.1|3307296_3307719_+|VOC-family-protein
MIKKLAHVCLFTDQLPAMIAFYRDTLGFPIKFTMKNDAGVDFGYYFATGEMTFVEIFDQKKAVAQWGGEVVAMKSNHTAHARHFCFEVNGLEQEVARLEAKGLAVKPVKVGMDHSKQAWIQDPDGNDIELMEYTPQSLQW
>NC_010571.1|WP_012375389.1|3306886_3307252_+|cupin-domain-containing-protein
MNPIDLTAAFATITTHWDPHIVGELNGQYVKCVKLRGDFVWHHHDHEDELFLVHRGTLEMRLRDRTVTLQPGQFFIVPRGVEHQPAARDEVEVVLFEPAGTLNTGNVREARTRDTLKRLDR
>NC_010571.1|WP_044892481.1|3305560_3306784_+|class-I-SAM-dependent-rRNA-methyltransferase
MEKPSKAPPPVVNRAAWPKPWAQLKYFTFQPAIFPRLLGQVSPDARPGDFVNVYDKNGQLTGGGLFNPRAKIPLRVVTHSTEPVTEAYFETAIRRAVALRRELFKLDETTDAYRLINSDGDGLSGLTIDRYADTLLCEVYSLGIAQRLPGWLPLLHELAGTKFARVQVDHDLGSLEGIKPSTFKETNAAAPRLVKIREHGVRYEVDFAEGHKTGFFCDQRENRKLLAKFTRGARVLDLCCYTGGFSLNAKVAGGAEEVTSVDLDEAAIAQAKRNANLNQARLKFVHADAFAYARQMQQNGEKWDVVVLDPPKFIFTRDDHGNWEGRQKYEDLNLLAISLVKPGGIFVTCSCSGLLSLEDFEQHVIKAAHRQNRRLQFFDRTGPGPDHPVYSNCLESRYLKVLWARVV
>NC_010571.1|WP_012375387.1|3304983_3305442_-|hypothetical-protein
MDLNLSHLPLANLGLEPWMISIVVPVVGLVFAGVIIVTTFYFKHRERELWHQTARVALEKGQPLPVLPDSAGFGDAAAAVKAATAANNQPRWRGYLIGGLINLAVGAGLFVSLSQISGASFNVGYFGCIPGFIGIALLLGAVIEAFASRHKS
>NC_010571.1|WP_012375386.1|3304419_3304962_-|RNA-polymerase-sigma-factor
MTPSDSDLIAGVLARDDRAAFGELVRRHQSMVRNFLRHLTRGDIALADDLAQETFIHAYRQLGRFRGDALFSTWLLGIAHNHWRNARRRQREHVEFSEHHLPAGPAGNASAAVDLRHDLATALRTLSPDEQLAIHLGYEQGLSHTEIATLVDWPLGTVKTHLARSKEKLRHLLAAWNPQA
>NC_010571.1|WP_012375385.1|3304063_3304438_-|hypothetical-protein
MEPSSLNASPQEDAALTAMLRAQSPVIPDDGFSARVLAALPPPQTARARWPWVAYVGGGLAGAIFIVARAGSWPDLVAGTNQLAGALSTVAAPLTEPWLVLALILTALSLVITLPFTQPRWRLW
>NC_010571.1|WP_012375384.1|3302614_3304000_+|thymidine-phosphorylase
MTKRTIPARRFIKPTFEYLIEKKRDGGEFTQEEIRYIIDSTLDGEMPQHQLAALMMAIYFSNMSAQETADLTEEMMLSGEVIDLSHIAKPKIDKYSTGGVGDKTSLVLVPLAMASGVIVPMMCGVEHDYVINTLEKLGAFPGFKGQMPIEQFTNQLARIGGAIVQQSDALAPADAKFYALRKETGTIPSLPLITGSVLSKKLAEGSEGLVIDVKWGNGSFIKDLEQAKQLARSMTRVGRSMKRRCVALVTDMNQPLGDTVGTSLEVKEAIQLLKGEGPEDMKELVLKLGMEIVRLAGVAGSTLSAKQTVQRHLTDGSALQKFKDLVKAQGGDTMFIDHPEKFPAARHIRKLPAPKRGYVHTINAAMIARGVHLLGAGVEAAAPTGNHNHGAHSHGHAKVDHAVGVSEIKKVGTQVKQGEPLMMIHYNDEAKLEQALEYFKNAYRLAPKRPTPPPLIVERVA
>NC_010571.1|WP_012375383.1|3300196_3301969_-|arginine--tRNA-ligase
MHVPFSLVDELDRVLKSAAAAAGFDAAAFSPEVRVADAQHGDYQANGVLGYAKSRKQNPRALAEKLVAALPAEFTQSTRVTIAGPGFINFTLAPGSLLAWLRTYATAEQLAAGAAADHAGQTWVVDYSSPNTAKQMHVGHLRSAVIGEAICRLLAFTGARVIRDNHLGDWGTQFGKLIYGYKRWADPAALAADPIEELERLYKLGHHATPEGSPELEEAKRELVKLQSGDPENVALWKKFSEVSLGAFQQIYDRLGIHFDHHLGESFYNDKVERVYGELTDIGLAENSDGALVVFHDEHPRFSRNAERPNPFMVRKADGASGYASTDLATALYRTEHFQADGIVIVTDFRQSDHFEQLFLTVKKWFAAKGYRLPQLHHVTFGAVTGEDGKALKTRDGGTIKLKALLDEAVERAFAIVSEKNPELPEDERRAIAEAVGVGAVQYADLSQNRSSNYVFSWEKMLSLEGNTAPYLLYAVARIHSIFRKAGATPGEPATESAATEPETPTEIALARKLLKFPDAVRLATETLRPHFLSLYLFELAGDYSTFNNADRVLVDDPVIRARRLLLCSRTLLILETGLRLLGLRPLTRM
>NC_010571.1|WP_012375382.1|3299162_3299912_-|DUF4339-domain-containing-protein
MATQEFYIRGETDTEARGPFNLEQLTSLAESGQVTPATLFYDATTEQWTAIETNAEVRSLLFPEKKKLSVRAKQQLNTLNQEQADAAPITVNDMLAAAEGRTADTKDKRDPILAMARAAAIGRWSAIVALVLAAAGEMLPATEAITSMAVSKILAQPLVILGAIDLLLAVMLVLGVVSVYPLVRFRAALGLGFLGFIFWTQGQALPFLACTAASVGLFGCTVAVSLLPVLIAAVLAVGGFAFVALHLLS
>NC_010571.1|WP_012375381.1|3297514_3299140_-|YihY/virulence-factor-BrkB-family-protein
MFRLADRWRRFLALYRKEIWQPGQLQERTPRGMLYALLRIVSITWTVFCETKAASRAAALSFSSLLGLGPLVALTVLIAGFALNKDDPNLAANALSRLINFVAPQVGQYSRLDEERASRPAGSARVSPAPVEAAGETPAHPGSASAAPTAAPTAPAPPRLEARPFPDVRLNPRLVQMMNNFINQGRSGSAGTVGFFGLVIIVLLLFKTVEDTFNEIWGVRSGRGVLMRIVYYWTTLTLGAVLFFASVTLLSAGAFFSVFNNALADLPFSAQMAAMLQWSLPALSFTLVALLLTIFYRVIPHTRVFWRSAFTGAIVVAALLMLNHYLAFLYVRRVILTESLYGSLGLPLVMMFGLYIFWLYVLIGGQISYAVQNVHFRNSQAAWGNLSQSMRERLLLVVLLTICRRFRDCRPPMTTSELGEMIKVPTQILNECLNRLADLQLVTAVPPRTPDDPTDLRYQPARPLNRITLRDFKRLDDDFGDNPMVGALEHIDPVVAHYRQAVTHTTESDFFSKSLEDLLAEHPFDAPRLPDGAGAPPAANG
>NC_010571.1|WP_012375391.1|3307987_3308641_+|carbonate-dehydratase
MDALGRLFAQNKAWANDIRARDPLFFEKLSRQQTPEYFWIGCSDSRVPANEILGLLPGEVFVHRNIANVVVHTDLNCLSVLQFAVDVIKVKHVMVVGHYGCSGVGAALRCERVGLADNWLRHVQDVREKHDGCLCGLQGEAAQAERLCELNVIEQFANVCETSIVRDAWKRGQPLAVHGWIYGLRDGLLRDLGCSASNPDEATSGYENAVANLTKQP
>NC_010571.1|WP_012375392.1|3308798_3309356_-|elongation-factor-P
MPAANDIRKGQVIKYNGEPHLVMETQHRTPGNLRAFVQVKMRNLRYGKALDQRFASTDTIEVLPTDKRTLEFSYADRETFAFIDPDTFDQIELSAQTLGEVKNYLTAGGKVDVLFVDDKPLTVELPSTVALKVVESSEGIKGDTASNVQKPATLETGLVVQVPLFIKEGEIIKISTADGSYLGRA
>NC_010571.1|WP_012375393.1|3309564_3310905_+|bifunctional-UDP-3-O-[3-hydroxymyristoyl]-N-acetylglucosamine-deacetylase/3-hydroxyacyl-ACP-dehydratase
MKQRTLAREVSIKGSALHTGDPVTLTMKPAPVDHGIVFKRTDLHGSPELRPRVDQVTDLVRATTIQSGHAKIHTVEHVLSALHGCGIDNVLLEMDASEPPIMDGSARPFVNLILQAEPVEQDKDREYFELDAPVSVTRGNSSIIALPSDVLKISCTSADDRGIHTQHLSLTIDPEVYQTQVAAARTFTIYEDIEELLKLGKIRGGSLDCAVVIRGDKIISKEPLRFKDEFVRHKILDIIGDVMLLGLPLKAHIVATRPGHAINAELTKAIYQKLLERKQGGTKKKEKPVAPTMLLTDETSLDIRRILDTVPHRYPFIMVDRVLEIKGPDELVALKNVTINEPYFQGHFPGNPVMPGVLQIEAMAQAAGILMLRKISSEGKTALFMSCDKVKFRRAVRPGDQLLIQVKMTKSRGNRIGVAEGQCSVNGQVVSSAELMFTVIDETDVE
>NC_010571.1|WP_012375394.1|3310985_3311774_+|acyl-ACP--UDP-N-acetylglucosamine-O-acyltransferase
MSSKIHPTAIIEPGAQLGSDVEIGAYAFVGTGTTLGDGTRLHHHASVEGNTVLGKACEVYPYACIGGKTQDLKYKGGNPGLRIGDRNVFREYVTVHAATKDGENTIIGNGNNLLALSHVAHDCVLGDGIVMSNNAGLAGHVTVENHVVIGANAGVHQFCRLGAFVMLSAYAKLVQDVPPFFIADGAPATVRTFNKVGLERNGFTPEQIERVKTIFRMLYRGGLNRTQALEQLAAHEQAASAEFQRVLEFAKKSERGMAAGGR
>NC_010571.1|WP_012375395.1|3311816_3312038_-|hypothetical-protein
MKRLLQASGRTIEEFVGTSDHGEFNQALAGAIKTAQLTLGTEEIRWTMLQLSGQTAPGAHALTVAIKAKRSDA
>NC_010571.1|WP_012375396.1|3312108_3312564_-|phosphoribosyl-AMP-cyclohydrolase
MSTPAFPARTTTADIELGTTLQPKFGPDGLIPCITQDVHTGEVLMFAFMNAESLAHTLRTKKATYWSRSRNKLWMKGEESGNVQHVHELRTDCDQDVVLIKVEQTGAANASCHNGYKSCFYRKLASLDASSLQLQFTAERLFDPATVYKKK
>NC_010571.1|WP_012375397.1|3312903_3313203_-|DUF971-domain-containing-protein
MHTPTNIQLIGSEVAIAWDDGAETYYAFDQLRAASPSAETQGERDVLGNQYGGDGPRRFPGVQVVGWERIGNYAIRFDFSDGHRTGLYSYDYLRELAQR
>NC_010571.1|WP_012375398.1|3313348_3314659_+|NAD(P)/FAD-dependent-oxidoreductase
MDASEKPRTLPHIVVVGAGFGGLTFCRKFPEDAARITVIDRQNHHLFQPLLYQVATAGLSAVDIAQPIRAILRRKKNLEVMMAEVTGFDLAARKVIHDRGETSYDYLVLAMGGRTSYFGHDDWERFAPGLKSLDDALEIRRRVLMSFECAETESDPQKRRELMTLIVVGGGPTGVELAGTFAELARTVLVRDFDRIDPSKARVLLIEGAPRVLAHFPPDLSASAQRQLERLGVEVRVGKHVKAIRHHEVEMPDGEIIRGIVIWAAGVSASPLTQQLGVETDRAGRIKVLPDLSLPGHPEVFVLGDLVTLTDPKGQVVPGVSPAAMQMGEHAVKLLAEEIRGRTSTTNAAAGRAPFVYWDKGSMATIGRSKAVAEIGRLHFSGYPAWMAWLFVHLIFLVGFRSKFSVFVQWVYSYLTYKRGARIITGATGTPPAGSA
>NC_010571.1|WP_012375399.1|3314733_3316764_-|hypothetical-protein
MQRFRSSLILATLLAPAALLAQTVTTSGTVSVSAGGTLLEGNRAAYQRTVQHAKQGFAGIEDFNLTREAEDSVFKFDARLLPGDEDYRVSFRFDKTDRFYIEGGYEQFRVWYNGGGGYFRPRGMAFTLFDEDLSLDRTRAWLEAGVYLPNQILLRARYEHRARNGTKDSTMWGDSNAPAPYGTRNITPSLMDLNETTNTFSVDIGNTTQEDQKWNVGGRVSETKIDDKRYSRRRPFDSGGDRIITTKDESSNDLYAAHGFYLRKVNDQLTVSGGALITKLDTVIEGSRIYGQSYDPVYDPNYARRQQRDEGFYNLEGKADVKQTVLNLNAVYTPRKDWSIRPSIRFENRRDEATDEFVEINTGPAPAVAPILEALEGENDKDWSEFTEEIEVRYTGKPNWTFNGTAEWLQGTGNLEEMLGEAGVFAINRDVDLDRFVQKYSFGANWYAKPGLTFAAQYYYKGSMADYGLTRDNTPPYGGDRYPSYIIDQDFETHDVNVRVTWRPVTQLNLVTRYDHQESKVTNVMAGLGKSPSGDYSSDIISQNVTWSPTARLFVTGSVNARYDQLATPAYPFVQNGDNNSINGSLGAGYVVSQKDDVFVDYHWFDADNYIDNSRTSLPFGLTDTQNAFYVTWVRRQTEQMIYTVKYGYVTNDDYTYGRRNDFEAHVLYAKVQYRF
>NC_010571.1|WP_044892482.1|3316787_3317357_-|hypothetical-protein
MAQGENAKAMGCEACHGPGSEHVKAGGGAGTIINPEKNPETCFQCHLDKRGEFSLPNAHPVMAGKMTCSDCHNPHEGDAVMGGGTNLMGANESCLKCHEAQRGPFVFEHEALRESCTSCHNPHGSVNAKMLNARNQSLCMQCHTQQQTAAGQLMIGGRDHAAFVTRGTCWTAGCHEAVHGSHVNSSLRF

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Crispr_ID: NC_010571_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010571_3

4503086-4503190

Orphan

Consensus_repeat	Method
CAAAAGCAGAACGATCGGGATCGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010571_3

>merge|NC_010571|3|4503086-4503190|CRISPRCasFinder
CAAAAGCAGAACGATCGGGATCGAGAGCCGAGAGCTCAGTGTGCAGATCCGAGTTTGGCCGCAAAAGAGCGCAGAAGGCGCAAAAGCAGAACGATCGGGATCGAG

>NC_010571|3|3|4503086-4503190|CRISPRCasFinder
CAAAAGCAGAACGATCGGGATCGAG	AGCCGAGAGCTCAGTGTGCAGATCCGAGTTTGGCCGCAAAAGAGCGCAGAAGGCG
CAAAAGCAGAACGATCGGGATCGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_010571.1\|WP_012376258.1\|4492363_4493059_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NC_010571.1\|WP_012376268.1\|4501437_4502817_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_010571.1\|WP_044891857.1\|4498224_4499406_-\|oligosaccharide-flippase-family-protein	unknown	unknown	gnl\|CDD\|240533
NC_010571.1\|WP_158305472.1\|4495526_4496438_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|366154
NC_010571.1\|WP_012376269.1\|4503482_4505204_-\|single-stranded-DNA-specific-exonuclease-RecJ	unknown	unknown	gnl\|CDD\|273193
NC_010571.1\|WP_083767865.1\|4516427_4516850_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|223427
NC_010571.1\|WP_012376275.1\|4513939_4514410_-\|four-helix-bundle-copper-binding-protein	unknown	unknown	gnl\|CDD\|153434
NC_010571.1\|WP_012376262.1\|4496489_4497284_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133055
NC_010571.1\|WP_012376266.1\|4500088_4500685_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224427
NC_010571.1\|WP_012376274.1\|4512411_4513722_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366721
NC_010571.1\|WP_012376260.1\|4494145_4495534_-\|O-antigen-ligase-family-protein	unknown	unknown	unknown
NC_010571.1\|WP_012376270.1\|4505304_4507854_-\|protein-translocase-subunit-SecDF	unknown	unknown	gnl\|CDD\|237276
NC_010571.1\|WP_012376272.1\|4508622_4510560_+\|biosynthetic-arginine-decarboxylase	unknown	unknown	gnl\|CDD\|235427
NC_010571.1\|WP_148218167.1\|4517060_4517510_+\|chemotaxis-protein-CheD	unknown	unknown	gnl\|CDD\|319352
NC_010571.1\|WP_012376273.1\|4511606_4512056_-\|GatB/YqeY-domain-containing-protein	unknown	unknown	gnl\|CDD\|370480
NC_010571.1\|WP_193372192.1\|4507938_4508274_-\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|235518
NC_010571.1\|WP_012376265.1\|4499504_4499888_-\|four-helix-bundle-protein	unknown	unknown	gnl\|CDD\|377534
NC_010571.1\|WP_012376276.1\|4514604_4516176_+\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|223200
NC_010571.1\|WP_012376263.1\|4497280_4498222_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|182223
NC_010571.1\|WP_012376259.1\|4493079_4494123_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831

Protein	Function_ID	Function_description	E-value
NC_010571.1\|WP_012376258.1\|4492363_4493059_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	3.22193e-16
NC_010571.1\|WP_012376268.1\|4501437_4502817_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	8.66884e-24
NC_010571.1\|WP_044891857.1\|4498224_4499406_-\|oligosaccharide-flippase-family-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	2.65538e-11
NC_010571.1\|WP_158305472.1\|4495526_4496438_-\|glycosyltransferase	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	1.67793e-20
NC_010571.1\|WP_012376269.1\|4503482_4505204_-\|single-stranded-DNA-specific-exonuclease-RecJ	gnl\|CDD\|273193	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ. All proteins in this family are 5'-3' single-strand DNA exonucleases. These proteins are used in some aspects of mismatch repair, recombination, and recombinational repair. [DNA metabolism, DNA replication, recombination, and repair].	1.75192e-158
NC_010571.1\|WP_083767865.1\|4516427_4516850_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	1.40336e-46
NC_010571.1\|WP_012376275.1\|4513939_4514410_-\|four-helix-bundle-copper-binding-protein	gnl\|CDD\|153434	cd08026, DUF326, Cysteine-rich 4 helical bundle widely conserved in bacteria. This functionally uncharacterized protein forms a 4-helical bundle with a bromodomain-like topology. It is present in major bacterial lineages and contains highly conserved cysteines in a repeated pattern, whose sidechains appear buried. Some family members have been (mis)annotated as putative ferredoxins.	1.08017e-21
NC_010571.1\|WP_012376262.1\|4496489_4497284_-\|hypothetical-protein	gnl\|CDD\|133055	cd06433, GT_2_WfgS_like, WfgS and WfeV are involved in O-antigen biosynthesis. Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	2.85738e-35
NC_010571.1\|WP_012376266.1\|4500088_4500685_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224427	COG1510, COG1510, Predicted transcriptional regulators [Transcription].	5.45587e-16
NC_010571.1\|WP_012376274.1\|4512411_4513722_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|366721	pfam01593, Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	4.3543e-50
NC_010571.1\|WP_012376270.1\|4505304_4507854_-\|protein-translocase-subunit-SecDF	gnl\|CDD\|237276	PRK13024, PRK13024, bifunctional preprotein translocase subunit SecD/SecF; Reviewed.	0
NC_010571.1\|WP_012376272.1\|4508622_4510560_+\|biosynthetic-arginine-decarboxylase	gnl\|CDD\|235427	PRK05354, PRK05354, biosynthetic arginine decarboxylase.	0
NC_010571.1\|WP_148218167.1\|4517060_4517510_+\|chemotaxis-protein-CheD	gnl\|CDD\|319352	cd16352, CheD, chemotaxis protein CheD stimulates methylation of methyl-accepting chemotaxis proteins. This family contains bacterial chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs). The CheD chemotaxis gene is not found in the Escherichia coli genome, but is present in many other organisms, including B. subtilis, where CheD appears to have two separate roles; it binds to chemoreceptors to activate them as part of the CheC/CheD/CheYp adaptation system, and it deamidates selected residues to activate chemoreceptors, enabling them to mediate amino acid chemotaxis. CheD has been shown to catalyze amide hydrolysis of specific glutaminyl side chains of the B. subtilis chemoreceptors McpA, McpB and McpC; deamination by CheD is required for the chemoreceptors to effectively transduce signals to the CheA kinase. CheD's ability to bind the receptors is controlled by CheC via a competitive binding mechanism; substituting Gln into the receptor motif of the signal-terminating phosphatase, CheC, turns the inhibitor into a receptor-modifying deamidase CheD substrate. Also, CheYp increases the affinity of CheD for CheC, controlling CheD binding to the receptors through its interactions with CheC. Thus, high levels of CheYp means CheC is a better binding target for CheD than the receptors, resulting in decreased CheA activity. The CheD structure reveals a distant homology with a class of bacterial toxins represented by the cytotoxic necrotizing factor 1 (CNF1) as well as a class of proteins of unknown function represented by B. subtilis YfiH. An invariant Cys-His pair forming a catalytic dyad is observed, and is required by the toxins for deamidation activity.	7.20529e-43
NC_010571.1\|WP_012376273.1\|4511606_4512056_-\|GatB/YqeY-domain-containing-protein	gnl\|CDD\|370480	pfam09424, YqeY, Yqey-like protein. The function of this domain found in the YqeY protein is uncertain.	9.71675e-33
NC_010571.1\|WP_193372192.1\|4507938_4508274_-\|preprotein-translocase-subunit-YajC	gnl\|CDD\|235518	PRK05585, yajC, preprotein translocase subunit YajC; Validated.	1.03054e-35
NC_010571.1\|WP_012376265.1\|4499504_4499888_-\|four-helix-bundle-protein	gnl\|CDD\|377534	pfam05635, 23S_rRNA_IVP, 23S rRNA-intervening sequence protein. This family consists of bacterial proteins encoded within an intervening sequence present within some 23S rRNA genes. It folds into an anti-parallel four-helix bundle and forms homopentamers.	1.61514e-23
NC_010571.1\|WP_012376276.1\|4514604_4516176_+\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	3.74857e-42
NC_010571.1\|WP_012376263.1\|4497280_4498222_-\|glycosyltransferase	gnl\|CDD\|182223	PRK10073, PRK10073, putative glycosyl transferase; Provisional.	4.59583e-27
NC_010571.1\|WP_012376259.1\|4493079_4494123_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	1.39471e-27

>NC_010571.1|WP_012376268.1|4501437_4502817_+|Gfo/Idh/MocA-family-oxidoreductase
MPAPTLTRRQFAKALGAGALTAPLIVRHLFSAPPSRVLRHASFGASNMAWADLQAICSNPFVQLVAVAEVDRNRLGDVLAAFPDVKVYQDWRELLDQERDLDSVNVSTPDHQHAVMALAAMERGKHVYGQKPLAHDLHETRALTDYARRHPRLVTQMGIQIHSEKSYRTAVALIQSGAIGLIREVHTWSNKKWGDQGPPPPVGDPVPEGFDWDLWLGGCAERPFVGRDYYHPGNWRKRLDFGTGTFGDMGCHIFDPVFEGLALTAPLSVRSEGPAPDAWNWSTDAVIRYVFPGTRYTEAATIPITWYDGDQRPPAEIRALVAPANPPARASTATPARPADPRDEGSILIGTKGVLHLPHPEMPRLCPVEQFKDYLLPQVTGSHHWSDWAEACVGGAARPLAPFAYSGPLTETVLLGSVAVRFPQTTLRWNSARLRFENERAANAFVRRRYRRGWRLGSV
>NC_010571.1|WP_012376266.1|4500088_4500685_-|helix-turn-helix-domain-containing-protein
MSRLPPAPASDDPYLAAPGAEVTAEFQQACVEFFGDVVHALGVPRSVGQIYGLLYASPQPLSFTDIAEKLDISRGSTSQGLQALKELGAVVPVGDGSREQGAGSRNGNPAAGGGQRQLFQPQLELRQLVGGLLREKVTPLVNEGPGRLKRLRELAESSPTPAGKKFAEKRLAKLDTWRRQMRLLLPLLKTILGPVRRA
>NC_010571.1|WP_012376265.1|4499504_4499888_-|four-helix-bundle-protein
MPAPIHSFEDLECWKAGREVRLFVAKQVVPLLPISEKHRLSDQIIRAARSITANIAEGYGRFHHLENAKFCSIARGSACEGLDHLITGADGPPTCLIRATHIQGGREQMPGPSELLAEYATVTQRSR
>NC_010571.1|WP_044891857.1|4498224_4499406_-|oligosaccharide-flippase-family-protein
MIVQAANLVAPLCIYPYALRALGADVYGKYANVNALALIVSLVADFGTTTTGPREVATARDDPSELRATTSALVKLRLFLAILAAIAVNIYYLYSEDLVLRTLGQWSSLLVLSCAVFPLWYYQGREQLMSIALSYGIARIASIGAIYLCVSDASDYGEFYAISLAPQLLVGVVFFVILIRHSSLTLQSVTSVRLSSSLKLNWRVALAASATAIKDRGPVALTASVLSFGDIAKLDFGSKIVELVASVSYNITRAVYPSFCARPDTRRLAVFVYSGVATGCIVSACLAIGSETIASLVGGVALAGAGPLLGVMGWALPGLIASSFIGHLGLLAHRQDGWYFTSVLLSSLAIVALLAGAVLAFPGNATKIAWTVVLGSVGEAVLRFAIARRSRAL
>NC_010571.1|WP_012376263.1|4497280_4498222_-|glycosyltransferase
MDKLLSIVIAAYNVEPWVDDCLLSIESQRDDRLDVVIVDDGSTDGTSDVIRAHKKRWALQCVTKKNGGLSSARNAGASAAGGRYLWFIDADDMILPGAVACMIAQCEQQRFDAIVFGTEEIMEGHRVPHRPRPIVGTPLESYLAGHLRFAVWNKILRAEIVNNHRIRFPIGCSMEGISFLGAFFLHASNVKVVPDICYAYRIRPGSIVTSASERILSDTRLALTELEKELVDHASERGTRRGLARCASALWAVRIAEVMRWPTERRRAGLACIWVLGKQDLSRIGCALIALDMVVWRKTVRAIAMAYKIVVGI
>NC_010571.1|WP_012376262.1|4496489_4497284_-|hypothetical-protein
MSRLLSIVTITKADRIGLVRTKASIEQQQNCPDIEWVVVGATDSDLEVVGSGPAATGLCDGGISAALNLGARLATGRWISYLNSGDIYAREDVLMRVSPVLERLNANRIVVYGDFYEAGDGFRHLRHANRDTIQIANSINHQSVFIGRELAMREQYDERLLLGMDYDLWLRLDRWAEFHHLGFPVAEFHWGGRSSRRDWASHQVMVRYFLRKLNNREQMRARDIWNLSVQLARAWVRHTCINSVAPGWQSRKGRTQHAKRPKGF
>NC_010571.1|WP_158305472.1|4495526_4496438_-|glycosyltransferase
MRDRPIELRRALRSVLAQTCNDIEVRIIDDASLQPIDSALGSEFLDERVIVSRLNSPFGAARARNVGVNQSRGRFVAFLDSDDEWYPNKLAAQLRHIAMAPTGVISYHRILVDDGGPERPRPVRAIARGEDVAEYLFVAGCNIQTSTLLAPREVWLQVPFRDGLAKHQDWDIAIRAQAAKIQLDCCGETLAVYHGRAKLGRISNDSDYDYSIAWAQSVGRLSRRAEACFWLRVVVPQIRSRHGFCRASGTFVKYVAAARLGAASLCRLFVRACLPGIYSHCCQVARRLSPVRPPCESLKKGHE
>NC_010571.1|WP_012376260.1|4494145_4495534_-|O-antigen-ligase-family-protein
MNRPKRTTTQAVSNASAVVLILLWCAPILYVPWWVHIVLLATALALTVFQRIAIGGLFLVGLLPLAAVAAEFINAGASDNLIGILGFWLPQVSVFSISLVVFHRVGVFRCALIPLCAAIVAALPMAPEAMGVYIRDMLPNYQDRYGGMDSFFMQYGSTERLRALFGEASTLSATLVLLSLLSGCAALAAEQQKVLRAPTATGMVLLCMVVAALGVLVPLSKAGVTICVVVAPFLVVAAIRFPSRERRLRVIGIAVLLVAAAIGFTLVSRSRGYLEAELAGVRELLTFANTSGTGTGSRLLHWRFTLEHVTRFPFGAGFSGVSEVFSAPAGFSPNAEMLRRIPNGVYGMMNAFANVCVQSGVIGVLTMGALIFGGIRLRVLPRAAGVGCLRCACFTGMLSFLLLVETYYFLSLLPLLWEVDRQLVCPQESTKRLARLWTDAKRTPSRETKGTVVDRTIHIGQG
>NC_010571.1|WP_012376259.1|4493079_4494123_-|glycosyltransferase-family-4-protein
MRQIAALSHSGCSYVFACPNVPVFRARVSASVPGVSFVDMPHRSLSFVHIWTMLKLIHETRGPIVVHSHGRGAGAYSKIICLAARCVVIHTPHGCHFAAGAHRWFQRLVEGVGILLSGCTLFVSKSEQIEFMGTLKYGATMVIPNGVAPPLSSVVADVTRRVDVYFVGRDNWQKDPVLALFIARQLIQRCGNESRFRFHFFGEGLDATSDFGRTAIKALGSAVVMHGIVADVWSWGSPAFILNTSRWEGMSLALLEGMVRGAVPVATDVSGNRDVVRRGANGFLFSRDAPDSAVDWIWECVRDQQCYEMLRRSAIAQVLQNHSIERVAANVEKVYTGLLSLQVGRIM
>NC_010571.1|WP_012376258.1|4492363_4493059_-|class-I-SAM-dependent-methyltransferase
MKRCTRIHIALNKTINRCLSKYAMRKGALLDVGCWNGATTLGYARTIAAIDIWGVEAMAEPAREAELLGVKVKIIDIEEQEFGMETGRFDVVVCNQVLEHLKNIFRPFDEIARVVRPGGIVILSVPNLASLHNRAMLLCGYQPSSIRIWGPHVRGFSQRAFTEFCVGHGLYKLKALIGVGFYPLRPEFGGNLLARFWTDACHTSVWVLERTGNPLMSYQCKYLNEGLQTIM
>NC_010571.1|WP_012376269.1|4503482_4505204_-|single-stranded-DNA-specific-exonuclease-RecJ
MRWTHTPVPTEEIEALSKGAGVSRVLAELLLRAGLRDAGGCATFLAPALAALQDPFLLRNVDAAATRLRQAIANQESVVVLGDYDVDGVSSTALLVSVLRRFGLLPRFVVPRRSEDGYGLSRSAIDRALEGGRPHLFVVLDCGTNSHDEVAYLREQGIDVIVLDHHRSKERALDGMLINPHVHRDDTGADGPWRHLCTVGLVFKLAHGLLKQLRAENHPVAFRIKLRDHLDLVALGTVADLVPLLGENRILARHGLTILQESRRPGLRALMEVAGVKPENGINPVDISFRLGPRINASGRLADAALSVELLLSEDLAFCQQTAQQLDAFNRERQEIERKITEEAEQLIETHYADSPGIVLFSEDWHPGVVGIVAGRVTRKYNRPCVVLGNEGEFAKGSGRSIDGLNLVEVLGTCCDHLVSWGGHPMAVGIALRKEHLPVFREQFAAAVRTQAGDAIAEARLELAAWLTPEQITPRLMDELEQLHPFGQGNAEPRFGVRGVVLRTAPEIFKTFHFRFNFEDQRGRRLHGVAWKMASRLLPVGVPVDLAVELKWNHFNDRKFLQLCLVDWRPSAG
>NC_010571.1|WP_012376270.1|4505304_4507854_-|protein-translocase-subunit-SecDF
MFRRNLWKLLLTLAMLGWAIATLIPLQDQPFVDYVKAHVTAKPAEFNALLAEASAMKREGRVLSEFVALKQIGKDRRLDLTQYFPDIRIESNLTNVEKRNEILLAELLRRSKSRLPLGLDLAGGVAFTLEAVQRPGDTADERERAEKLDKAIEIISTRINAFGVAEPLIRKVGNNRIEVQLPGVNTRDNPEIVDQVKAPARLDFRIVHPTLTPAPGVETPPGYEIMSLDYEGRRGETGSEELFIKRVPEMTGEAISNSFARPDMYGKPEVILQFTNEGKQRFAEVTRQIAEGGRQAGRLGRLAIVLDNKLYSAPTVREEINSESAQITGSFTDREALNLANVLNNPLDVELQVKEQYEVGPTMAESAVESGKRATYIGVGLVAVFMIGYYTIAGFVAVLSVTLNILVVLGVLASLGATLTMPGIAGIVLTVGMAVDAHILIFERMREELSAGKSLVAAFHSGHDRAFTTIVDANLTTLITSVLMIVFGNGPVKGFGVTITIGIFSTLFTALLVSQMLLDFLISSGRMKKMLMMSFLQPPAIDFVKYGKRAFIASWIVVAIGLSAIAFRGSSIYGIDFAGGDVINLAFKQEVNIEQVQRTLDNAKLGETLPFYQSEIGGGQRLLNLQTEAGKGQAAVATLKSAYPNAGFEVAGSTIVGPSMGREIQLNALLSIGLSILGIMLYVAFRFEIGYGIGAVVSTIHDVLLTIGIFVLSGRQFSAPMVGAILLIVGYSINDTIVVFDRIREELKNNPNTNLRDVINLATSRVFARSILTSLTTFLAALALYLFGGGVVNDLSFTFLVGIVTGTFSSLFIATPIFYWWHKGDRKHVEAHHDIAPKYEWTGSSKASH
>NC_010571.1|WP_193372192.1|4507938_4508274_-|preprotein-translocase-subunit-YajC
MFSPLEVPGFLAQQAAPGGSPWTQFIFFGLLFAAMYFLMIAPQRKKQKEHEKMLKALTSGDEIVTSGGIYGTITNVKDDRFVVRIADNTKIEVGKAFVTAVVKKVDGEAKK
>NC_010571.1|WP_012376272.1|4508622_4510560_+|biosynthetic-arginine-decarboxylase
MKSKSSSAWSAAKSEELYGFKRWGAGHISVDDEGFVNFQPRADERGIRVFDVVNEALGMGLKAPMVIRFQDLLRHRVIQLNEMFQKAIKEEGYKGSYRGVFPIKVNQLREVVDEIVAAGKDYAFGLEAGSKPELMIALAMHEGSQRLIICNGYKDHDYIRLALLGRKLGKKIIIVVEQLAELDDIIRLAAETGVKPMIGFRAKLQTRGEGKWALSTGDNAKFGLNTAEILFAIEKLRAAKLTQSLRLIHFHIGSQVPNIITIKNAVIEATRFYCQLAKMGFPMGYLDVGGGLGIDYDGSRTNFESSMNYSMEEYARDVVFNVREICTASDVEVPDIVSESGRAIVAPHSLLVVEVFERINKRESLGQQHQPKVKHKVVSDLEVMLKNKVRLGRLERFHDAIQKKEEAFSLFNLGYLDLENRAAAESIFWQICEQIAKEGRDSGYQPEELHELDKLLADQYVCNFSVFQSLLDHWALKQLFPIAPIHRLNEKPTVNAILVDITCDSDGKISSFIDLQDVKDYITLHPLNSKPYYLGIFLTGAYQDIMGDLHNLFGRVNEVHVFLEDDEPNGFYIEEALSGSRIADVIEGVQYQQEDLCRKMKAQIDAATRKDMVKPREGVRLLELYESQMLNKTYLSIDPKRGKKR
>NC_010571.1|WP_012376273.1|4511606_4512056_-|GatB/YqeY-domain-containing-protein
MATIYETLRADVVSAMKARNQQATVALRTADALIQRTSLDQGKPIDDALVVATLRKAVKNLADAKEEFAKGGRTDLVAANDAEIQLLSKYLPAGLDATKLEAIVVEAITETGAQSKKEMGKVIGALKQRPDAGLIDFAAASKLVQGKLS
>NC_010571.1|WP_012376274.1|4512411_4513722_-|FAD-dependent-oxidoreductase
MHQEPADVVVIGAGAAGMAAAATLARGGAQVVVLEARDRLGGRIWTHQPKGWSMPIELGAEFLHGENQALAAWLRRGRLQQIPVSEQHWLASGSQHTPIPDVWDRINAVMARIGPRYRGAFGAWLERHDDRIDDADQVLARTFVEGFHGAPLDEMSAHTLYRAARGPAEEQARIRGGYGRLVDVLERAMKDQRVDVRLNTVVTEVRWKRGAVTVVAKEAAWQARAVVVTLPVGVLQAAPGTRGAIRFVPALPQKEREWRRLGCGHAIRVVLRLRADVWRRGGLPAELRARQGRAFGFLHSDEPEFPVWWSEAPQPVLVGWTGGPAAARWSGASPQRQQRAARRVLARLLACPVTRLERVILDWRTHDWTADPFSRCAYSFSAAGAEHVPALLARPVQRTVFFAGEATADPLELGTVHGALMSGERAAREVRKEIES
>NC_010571.1|WP_012376275.1|4513939_4514410_-|four-helix-bundle-copper-binding-protein
MKMIETMLRSHPHADLQRSEAYADVLNALALCGQICTSCADACLGETEHLANLRRCIRLNLDCADVCQTTARLIVRQTETPNELIHSQLHACVLACQLCADECETHASMHDHCRVCAETCRHCQERCNFLLGEISASGVEEERADLRPTDSPPLSR
>NC_010571.1|WP_012376276.1|4514604_4516176_+|DNA-3-methyladenine-glycosylase-2-family-protein
MVASRATTPISPAVVSPTHRLRLSPAQMYARVLAGDPAWNGHFFTGVLTTGIYCLPSCKARKPKRENVRFFPTCEAARAAGLRPCKKCHPDDFARGADPVLESVEQLVAEMRANPAAFSEARALVRRLGFGVTRTFELLRLHYHTTPAELLTRARIAAAQQQLLAGATPLADIAYSVGFDALSVFHENFRRLTGLTPARYRELPHARSFELTLPDGYLLGYLRRALSRDAQSVSERLEGDVYTAAVNLSGGPALLTLRLNPSPVRVEVIPAAGGTGVPPVGSRPPTKGERVPDVASGVPTNTLEAHAIAIGLLGLEDDASSFARLARKLGLARLVAGRSELRISRIPSVFDGLVWAIIGQQINFSFACVLKRRLTELAGTRLSNGLMAPPTPTAIARLEPDELVPLQFSRQKAGYLITTARAITAGELDLAQLPSMSASRAERTLLALHGFGPWSVNYVMMRALGFADCVPLGDTGVTSGLQSLLHLEQRPDVDATRRLMAVFSPHRSLATAHLWQLNLPRPT
>NC_010571.1|WP_083767865.1|4516427_4516850_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MSRDAEWVSDQHRTGAVREQVGEYCGGARQEFDLPLAPTGSAFQQRVWTALRAIPFGTTCSYAQLAARLGLSGGARAIGGANAANPICLIVPCHRIIGSNGALTGFAFGEERKRALLEHERAATLAASRAPAVPQAACRA
>NC_010571.1|WP_148218167.1|4517060_4517510_+|chemotaxis-protein-CheD
MKATDLPHAAITTYALGSCLGVCCYDRANRIGGMLHAMLPDSSQSARRELKSAMYLDTGVPALLQSVIELGGDPKHSEFKVFGGARVGDGTDFFNIGSRNVEAMTALIHRYDLEVNYWHVGGQTNRTITLYLDNGDVRLRMPGRQEFIV

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Crispr_ID: NC_010571_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010571_4

4641332-4641434

Orphan

Consensus_repeat	Method
CGTGGCACCGGCGTCTCGCCCGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010571_4

>merge|NC_010571|4|4641332-4641434|CRISPRCasFinder
CGTGGCACCGGCGTCTCGCCCGTGATGCCTTCGCACGCAGCCTGTCGCCTCGCCTCTCCGTCTCGCGCTCGCGCCTCTTCGTGGCACGGGCGTCTCGCCCGTG

>NC_010571|4|4|4641332-4641434|CRISPRCasFinder
CGTGGCACCGGCGTCTCGCCCGTG	ATGCCTTCGCACGCAGCCTGTCGCCTCGCCTCTCCGTCTCGCGCTCGCGCCTCTT
CGTGGCACGGGCGTCTCGCCCGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_010571.1\|WP_012376371.1\|4641570_4642611_+\|ribosomal-small-subunit-Rsm22	unknown	unknown	gnl\|CDD\|286344
NC_010571.1\|WP_052300426.1\|4642836_4643526_-\|DUF1080-domain-containing-protein	unknown	unknown	gnl\|CDD\|368908
NC_010571.1\|WP_012376375.1\|4646200_4646785_-\|hypothetical-protein	unknown	unknown	unknown
NC_010571.1\|WP_158305476.1\|4630029_4630701_+\|hypothetical-protein	unknown	unknown	unknown
NC_010571.1\|WP_012376369.1\|4638861_4639830_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|378117
NC_010571.1\|WP_012376367.1\|4637121_4637898_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213260
NC_010571.1\|WP_012376379.1\|4651814_4652795_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_010571.1\|WP_012376376.1\|4646906_4647776_-\|serine-protease	unknown	unknown	gnl\|CDD\|223343
NC_010571.1\|WP_012376378.1\|4650073_4651564_-\|Mur-ligase	unknown	unknown	gnl\|CDD\|130153
NC_010571.1\|WP_012376370.1\|4640087_4641329_+\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379330
NC_010571.1\|WP_044891867.1\|4643751_4644357_+\|hypothetical-protein	unknown	unknown	unknown
NC_010571.1\|WP_012376363.1\|4630697_4631228_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NC_010571.1\|WP_012376374.1\|4644701_4646117_+\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl\|CDD\|223694
NC_010571.1\|WP_012376366.1\|4634693_4636832_-\|PAS-domain-containing-hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|237425
NC_010571.1\|WP_012376368.1\|4638042_4638834_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223673
NC_010571.1\|WP_012376361.1\|4629154_4629988_+\|ribosomal-RNA-small-subunit-methyltransferase-A	unknown	unknown	gnl\|CDD\|234708
NC_010571.1\|WP_012376380.1\|4652791_4654123_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912
NC_010571.1\|WP_012376365.1\|4633044_4634577_-\|xylulokinase	unknown	unknown	gnl\|CDD\|198375
NC_010571.1\|WP_012376377.1\|4647772_4649878_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NC_010571.1\|WP_012376364.1\|4631420_4632893_+\|B12-binding-domain-containing-radical-SAM-protein	unknown	unknown	gnl\|CDD\|379101

Protein	Function_ID	Function_description	E-value
NC_010571.1\|WP_012376371.1\|4641570_4642611_+\|ribosomal-small-subunit-Rsm22	gnl\|CDD\|286344	pfam09243, Rsm22, Mitochondrial small ribosomal subunit Rsm22. Rsm22 has been identified as a mitochondrial small ribosomal subunit and is a methyltransferase. In Schizosaccharomyces pombe, Rsm22 is tandemly fused to Cox11 (a factor required for copper insertion into cytochrome oxidase) and the two proteins are proteolytically cleaved after import into the mitochondria.	9.45049e-11
NC_010571.1\|WP_052300426.1\|4642836_4643526_-\|DUF1080-domain-containing-protein	gnl\|CDD\|368908	pfam06439, DUF1080, Domain of Unknown Function (DUF1080). This family has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16. However, the structure surrounding the active site differs from that of the endo-1,3-1,4-beta glucanase.	3.88542e-60
NC_010571.1\|WP_012376369.1\|4638861_4639830_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|378117	pfam09084, NMT1, NMT1/THI5 like. This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.	2.05718e-39
NC_010571.1\|WP_012376367.1\|4637121_4637898_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213260	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters. NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	3.08778e-102
NC_010571.1\|WP_012376380.1\|4652791_4654123_+\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	4.30193e-18
NC_010571.1\|WP_012376376.1\|4646906_4647776_-\|serine-protease	gnl\|CDD\|223343	COG0265, DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones].	0.000280731
NC_010571.1\|WP_012376378.1\|4650073_4651564_-\|Mur-ligase	gnl\|CDD\|130153	TIGR01081, mpl, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase. Alternate name: murein tripeptide ligase [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	1.30792e-119
NC_010571.1\|WP_012376370.1\|4640087_4641329_+\|SAM-dependent-methyltransferase	gnl\|CDD\|379330	pfam13679, Methyltransf_32, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.81598e-39
NC_010571.1\|WP_012376379.1\|4651814_4652795_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.01309e-92
NC_010571.1\|WP_012376363.1\|4630697_4631228_+\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	4.24725e-48
NC_010571.1\|WP_012376374.1\|4644701_4646117_+\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	gnl\|CDD\|223694	COG0621, MiaB, 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis].	7.82134e-154
NC_010571.1\|WP_012376366.1\|4634693_4636832_-\|PAS-domain-containing-hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|237425	PRK13557, PRK13557, histidine kinase; Provisional.	2.31514e-85
NC_010571.1\|WP_012376368.1\|4638042_4638834_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	4.26232e-48
NC_010571.1\|WP_012376361.1\|4629154_4629988_+\|ribosomal-RNA-small-subunit-methyltransferase-A	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	3.05185e-80
NC_010571.1\|WP_012376365.1\|4633044_4634577_-\|xylulokinase	gnl\|CDD\|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	0
NC_010571.1\|WP_012376377.1\|4647772_4649878_-\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	2.20629e-72
NC_010571.1\|WP_012376364.1\|4631420_4632893_+\|B12-binding-domain-containing-radical-SAM-protein	gnl\|CDD\|379101	pfam13282, DUF4070, Domain of unknown function (DUF4070). This is a bacterial domain often found at the C-terminus of Radical_SAM methylases.	2.6597e-41

>NC_010571.1|WP_012376370.1|4640087_4641329_+|SAM-dependent-methyltransferase
MTASPRERFFALLRAAVESHTLQKLTLGKYRGADASLRNLFVRPITLKSGPHLTFLWRHATRDVTKNHPPAEALADLDRLVGTDFLDAHLFTSTATAQLECQPDGPARLRTKKISGAAAPSPPPITHDRSKSHLIPADAPWLRALGVTNDRGQPREGMADKFRQIQRFAEVLSHLLAESGLASVAPHSDPSPATQPSTLNSQLPPSPLRIVDMGCGKGYLTFAVAALLGERARVVGVELRPELVAESNRIAREHHLDHCLQFTAGTIASTELSGIDVLIALHACDTATDDALAQGLAANAGLLVVSPCCQKELRPQLAAPRVLADALRHGIFQERQAEFVTDALRAQLLEWAGYRTKVFEFISTEHTAKNLMITAVKAHAPGDAARAARIREFAGFYGIRTQRLASHLGFTLG
>NC_010571.1|WP_012376369.1|4638861_4639830_+|ABC-transporter-substrate-binding-protein
MKRPLPLALTFLALALWMHGADRPLTKLTVQLDWMPEPEHGGFYQAQALGFFREEGLDVTLLPGGPNALVMPKVATGRADIGQADSTNTLLQQAEGLPVLQFAAVFQDDPSGLLVNAASSVHRFEDLQGKTIIARPEWAFLAFLEKKYQLKFAVVPQTFSVAAFLGNKEAIQQGYFIAEPHHIVKAGGEMPRFLSTWDAGFRAYAVLVTSRKFARDHPDALRAFVRAYLRGWRSYLEEDPTPAHAALKAANPSNTDEFMAFSRQKIIAEKLVTGRDASGGVTQIGRLDPARFDTQIRQLEELGILKPGKVTTAQAITTDFVP
>NC_010571.1|WP_012376368.1|4638042_4638834_+|ABC-transporter-permease-subunit
MPRRLLPLLLTVATGVAFVALWYGVHFWLSEDSRFLLPAPDAVLRAFGEYRTDLVRATLNTVYGALLGFALAIGVSILAAVVLSLSPIVRISLYPYLMLLQMTPIIIAAPILILWVGPGLPSVVLITFLICFFPLAVNTTQGLVSTDRNLVDLFRMWRASRFQQLVLLRLPAALPYFFTGLRIAATLAPIGALVGDYTAGSSAGDGGGLGFQALIYSSQAKYAALFATAAVTCVLGFVFVGFVLGASRLALRHWHDSFDPADK
>NC_010571.1|WP_012376367.1|4637121_4637898_+|ABC-transporter-ATP-binding-protein
MERSPLVEFQEVTKRFGDGPAVLEQISLTAAAGDFIGLIGPSGCGKSTLLRLIAGLSPITHGSLTIGGRSPEAAAADLAFVFQESTLLPWLNVAKNVEAPLRLRRIPGGQRVATRQRVLELVGLGDRGPAYPRQLSGGQKMRVSIARALALAPRLLLLDEPFGALDEMTRERLNEELLAIREQQAWTAFFVTHSVAEAVFLSNRIVVLSSAPGRIAAEVPVDLPYPRTAETRLSRAYHDLVTEVSRVLRQAESPRPVA
>NC_010571.1|WP_012376366.1|4634693_4636832_-|PAS-domain-containing-hybrid-sensor-histidine-kinase/response-regulator
MRIYPHGFALRTTLVYAAAAALWITFSDWAVLLLVQDVPAAARLSIYKGWAFVAVTSLLLYGVLQQWMARLKRQLDEQAKIEVELRQWADAFNHCAHGIAIGIPATNRLLACNPAFAAMHGFTVAEMNGRDVLTLYVPSDWEHVRRNVAIADRDGRVQFQANRVRKDGSVFTVQVDLVSVRDANEALLYRVTTVQDVTERNRAEAQRRESEDRFRAVVENIHEVFWIHDPSHIRIVYVSPAFEKIWGRPCAEVVNWDSETWLQTLHADDRERLRRVVQGGTPEGYDEQYRILRPDGTERWVHDRSFPVKDGAGRVVRIVGVAQDITERKQLESQFLRAQRLEAIGTLAGGVAHDLNNILAPMLMAAGLLKENITNEHDREMLSMVERSARRGADIIRQLLTFSRGVEGSRLALQIRHLVREMMGIMRETFPREITLIDQTKGELWPVVADATQLHQVLVNLCVNARDAMPHGGTLAISAVNVEFVAGDAQLPHDAPPGSYVMLSVKDTGVGMTPEIMERIFDPFFTTKDLGRGTGLGLSTVLGIVRSHGGFVNVSSEAGKGSDFRVYLPASRAEVAEPAAEPAEPLPLGHGELILVVDDEEPIRDATRHVLVKQNYRVVTATDGKEAVTAFLDQRDNVQLLLTDMMMPQMGGAALIRALRLLNPQLKVIATSGLDSHAGDGELAELGLSDILPKPCGPKALIESIQRALMRN
>NC_010571.1|WP_012376365.1|4633044_4634577_-|xylulokinase
MSLFIGIDSGTQSVKAIVLDLETRKVVAEARAPHQLIEGLPVGHMEQHPEDWTSALDFVIGEVVAKIGAEQAKRVRGIGVSGQQHGFVPLDENGAVIRPAKLWCDTSTAPECAIITKKLGGPKAAIRKTGNLILPGFTAPKILWLKRHEPENYKKLRHVLLPHDYLNFHLTGNYFMEFGDASGTAMMDVRTRKWSKDVIAAIDRKLADYLPPISESHQAAGTLRAELAAKYGLSTDVVVSAGGGDNMMGAIGTGNVAPGVVTASFGTSGTIYAFASKPVIDPQGEIAAFCSSTGGWLPLLCTMNVTTVTEQIRTLFGLDVRALDDSAAKAPAGANGLILLPYLAGERTPNVPDGSGVFFGLNQKTFNAAHLNRAAMEGVTMGMNYGLRRLATLGVKAKEIRVTGGGSKSPFWRQMMADIFGVPVVGMVEDEGAALGGALQAAWCVAIRDGNKKAKLTDFTTGTVALDESTRCTPNKANVARYRELQALQDKLSLALREVFADQRALANKA
>NC_010571.1|WP_012376364.1|4631420_4632893_+|B12-binding-domain-containing-radical-SAM-protein
MNILLVSPQTPDTFWSFKHVLRFVSKKAAFPPLGLLTIAAMLPRDWKLRLVDLNVERLRDELLREADYVLIGAMLVHQESVHEIVARCAALGKRVIGGGPLFTTGHEKFPEIAHFVLGEAEEIMPQLVADLVSGDLQPSYQAPRFPTITQTPVPRWDLINVRHYVTMAAQFSRGCPFDCEFCDIIVMNGRVPRTKTPAQFVEELEVLRRHGWRDMVFVVDDNFIGDKRRTRALLEALIEWRRRTNPKMGFFTEASVNLADDPELCALMVAAGFTKVFVGIETPSADALEECHKVQNRNRDLVSAVHTLQHAGLEVMGGFIVGFDSDLSDIFKRQFDFIQRSGVAIAMVGLLTALPRTKLWMRLKREGRLEAESTGNNTQAELNFVPKLSREYLQQGYRELMHRLYRPRDYYARIRTFLRNYQPKGPRLRLSRADLVAFLKSLWLLGVWHRGRIGYWRLFWGTLVKRPTKFRFALELAIMGYHFRRVARAL
>NC_010571.1|WP_012376363.1|4630697_4631228_+|N-acetyltransferase
MTPVDPEVLPPGIIVRDAQASDLPAIVSIYNEIIPGRMVTADLDLVTVESRLPWLQLHNPAHHPVWVVEENGAVIAWLSFDTFYPRPAYDGTAMLAIYVTKARRGSGLGRMLLTRAMRHAPKLGIRVLLGYIFAHNEPSLKLFAAHGFGRWAHLPGVAQLDGIDRDVIIMGKRVME
>NC_010571.1|WP_158305476.1|4630029_4630701_+|hypothetical-protein
MLRSCLLALALLSVPAFAQTGEPVDLLGKIEGRTYASPTGAFRVTIPVLPELGGRVMDTDNVVTFQDDFNVLSTIAAFPMDATQRWELSTRGLKDYLAYFFGNFVMPDFQQSIPGTRVESAKFAPSIGDGALLVYTLLPGGSMFNHRLTFVRPGERPPEAKRGNLLFVRNEWIYVLSIELAERVLERSTYNKTPAEEDEILRQRLIELREKMEFTTPAAAPTK
>NC_010571.1|WP_012376361.1|4629154_4629988_+|ribosomal-RNA-small-subunit-methyltransferase-A
MPLTPTATRELLAQLGHQPKRFLGQNFLVDGNIVRKSLELAQVRRGDAVVEIGPGLGTLTGALLEAGAEVWAVEKDRTLHAHLSSTLQPRHPDTFHLLEADAVEHPLADLPAAHAAAFKIVANLPYAIATPWLDAVLGGPLPERMVLMLQQEAAQRYVAMPGSKSFGAISVFLQSAYEVAPGHRVEASCFFPRPDVDSYLLHLVRRAEPFVFTPEVKALIRSVFQQRRKQIGGLLRDRLPDHGASWLARLTAAGLSSLTRPEAIPTELWRALQVRES
>NC_010571.1|WP_012376371.1|4641570_4642611_+|ribosomal-small-subunit-Rsm22
MTWDELDWPALDRLRDGFLRGGAASGHYWQNASDLASYDFTYGERIGWKWDHVLRELRLRGWSPRSRRIFDWGCGSGIAGRRVVEFFGAATFDELLLWDHSPVAADFAAAAASRAFPSLQVSPVTPGFLASDEPLGLLLISHVLNELSVDALASLRAMLERADAMLWVEPGTHEISRRLGQIRDALLPTHRVIAPCTHQLGCPMFRDGRERDWCHFFAPPPAGIHADSDWVKFGQRAGIDLRSLPYAFFATERTAASTDAPASIARAGETPVPAESVELSRVIGRAEHFKPYARVLSCDAAGLADLELPKRADPALFKQLERTKSPLLYHWHREGNKIVGGEPLAE
>NC_010571.1|WP_052300426.1|4642836_4643526_-|DUF1080-domain-containing-protein
MKTVVLGMLVLGLVGRMAASDVNSLTEDEAREGWRLLFDGSSLDGWRGFKSERPDKNWRVEDGALVLRGKAGDLVTQEAFGDFELTLEWKVAEGANSGVIYRVGLGEANTFTTGPEYQVLDNVKAHDNHPASHRAGALYDLEGIEEDVTRPVGEWNQARIVVSGWRVQHWLNGRQIVDVDLASPAGKALIAASKFKHWEKFASLARGHLALQDHGDVVSYRAIKLRELK
>NC_010571.1|WP_044891867.1|4643751_4644357_+|hypothetical-protein
MLQLDRFTEAPVPIKIIITIVWAGVFFAGLWILWWRTPATAKTPAPEVTSQMSDSSSKVVAGTVGQVQQGGAGSTFITHVAVNEPDSDRQTQDLYFRAISLAREILQFSADRQKSEPPYGPPSDRLNYERQISYSRTTVATYTERYSWRVTGILEELRREGLIDRSLESSNAHPTNPLGVESIGHDLTKISEQYRIAQAAK
>NC_010571.1|WP_012376374.1|4644701_4646117_+|30S-ribosomal-protein-S12-methylthiotransferase-RimO
MIKVSLISLGCAKNLVDSEIMVGHLHQAGMAVIPEAEKADVVIVNTCSFIDSSKEESIGHILEVHQHRGLRKRRKEQKLIVAGCMSQRFSKDLSSSLHDEVDAFIGLDQVTKVAPIIQEIYARERTKTDDPVSFVEGRSTFIPDYDTPRFRLTPKHFAYVKIAEGCNHPCTFCIIPQIRGRHRSRTVESVVAEVRQLVREGVKEINLISQDTTFFGMDTWEQRPNPRTPVDSGRGTALTTLLRQLNAIEGDFWIRLLYTHPAHWSDELIRTIAECPKVARYIDIPLQHISDAMLSRMQRETSGGYIRDLIARIRAGIPGIAVRTTFIVGFPGETDADVDELCAFISETKFERLGVFRYSQEDGTRAAKMPEQLSAKTKEARWHRTMALQKQIAADVSKTYVGRTLRVLVEEPGVARGEADAPDIDGRVYVPRELPVGEFADVTVTGYHDYDLLALPPGQKPAQWKVARQAQ
>NC_010571.1|WP_012376375.1|4646200_4646785_-|hypothetical-protein
MTPRFLEACQSLQSAEKATWDLLLRELPDAETLSPEVLNCAMDQTLDQLWSLLRDGPAEAGLQQATSAPPPLPAGGECLLTTHLPYFNAGERALELVAGEVLETEPPKTRRAHWRDCDELCAAFNVLVQCQLEALCRRCGRAAECRYGDLRAVAKLPSRHPFAMSPEAGDGHAAQPARSRKRRAHRAEEFETRN
>NC_010571.1|WP_012376376.1|4646906_4647776_-|serine-protease
MKRFPSFVIAVALLCGGAFSPRTAAATAETAAAGRALAARYADAVVGVELVVTLKVKSGGQEMPPREQRVEVNGVVIAPNGLTVTSLIEVDPQMAFESMRALQPGRPIELLGVDFKQVKLRLADGTEVPARFVLKDADLDLAFMAPEDATAEAGPRKFTHVDLATAADGAVLDRFFVVSRAAKVLQRTPLVQETTVIGIVEKPRRFYLLSQNMLSTAVFDPKGAVLGVTLQHLANGRRSGMVVLPAADIAEIARQVVFTKPAESAAPASPAAEPAAATGESTPDGAPKP
>NC_010571.1|WP_012376377.1|4647772_4649878_-|PDZ-domain-containing-protein
MVFQVTADEVMDASSLRKLLSGLIVCAVWSVAAAAIGATGKPTETAATTPTHDPMLAKIFPSIVRIEAIRLRPSDGRLTKQWTAGSGVVIAVEGRVLTNAHVTQDGDYFRCYLFDGSHIDAKLQGQDPLTDLAVLQMDLSQRPSGAPALVAATFGDSDALRAGDTVFALGSPGFLSQSVTRGIVSNPSLVLPEQTAGRMVLRGENVGTLVRWILHDARIFGGNSGGPLVNARGEIVGINELGVFNLSGAIPGNLARAVAAQLGKSGRVTRGWSGITVQPRLEANGRGAGVIVGDVAENSPAAAAGLRPGDLVTACDGQPIEGAEEKAVAHFNRLEMSRLPGDVFAIDFTREGAAQTIRLTLAERQPAQADDVEIRGWGAVVRDLTRELVREQRLPETAGVWLENVRPAGPCGQAEPILRREDVLLAVDGKPVATVAELRALTDRLLAAAPNHRRTVLASVRRDGAVLSSVVELRETSDHNVTQQARKAWLGAASQPLTPKLGDRLGIKAEGGARLTRIYPGTEAEKAELKVGDVVLALDGAPVTARRPEDTDVLARQIRQYRAGTSAVFTIWRDGQTRSLPVLLEAQPTPAAEMPWWEDTDLEFSVHDIAFDDRVRLQLSRDAQGVLVESAMPAGWAALAGLRSDDVIESASGRPVTNVAELRSERERAVAGKADWWVLLVRRAGQTLFVEINLKPAHSKS
>NC_010571.1|WP_012376378.1|4650073_4651564_-|Mur-ligase
MRIYFMGVCGTAMGNAALLARAAGHDVLGADVDVYPPMSTVLAQSGIALHEGYDAARLERLAPDLVVIGNAMSRGNPEVEWLLDTRRFAFTSLPAALHSLVLNVRRNIVVCGTHGKTTTTALTAYLLRANGRDPGFLIGGVPIDPPTGNHLGAAADPFVIEGDEYDSAFFDKRSKFIHYAPHIAVLNNLEFDHADIFRDLADVQRTFVHLTRIVPRNGFVVLNGDDENLRALGALPWTNVVRVGTGERNDLRIEAFRESAAGGEFGLSWQGQPWAEVRWPLPGLFNARNAAMAATAAQLALLPRDAARSGRVGELFASAAGAERLDLAALARFRGVKRRQEVLLDTPALTVIEDFGHHPTALAETLHSFRARFPGAILTAVFEPRSNTARTKALEAAFMRSLALADEVYLGAVNRADKLAAGERFDTVAVAQHLEQLGVKAHSAPTNAVLLEKMLAYSGARAERRRVVAFFTNGSFDGIIGKFVAAMSGSSSDAAS
>NC_010571.1|WP_012376379.1|4651814_4652795_+|ABC-transporter-ATP-binding-protein
MPAARLAADVRIRDLTKHYGRLAALRGISFDVAAGEIFGLLGPNGAGKTTTLECLLGLRRADAGALHVGGIDALAQPEDVRQIVGAQLQAATLQDKITPRQALQLAASFYAEPCPPDELLERFGLHAKAHAAFDTLSGGQKQRVLLALAFVNRPRLVVLDEPTAGLDPQSRRELHAVIRQLRADGCTILLSTHQLDEAGQLCDRIGILHEGRLVADAPPSQLIAGARALPKVVFTTAQPLTATMVSGLHGVASVAAHDGGWCADTRDVSGTITALTRQLERDGNPLIGLQIQRPTLEDVFLELTGRAWMPPANPLEGGVTDERNTP
>NC_010571.1|WP_012376380.1|4652791_4654123_+|ABC-transporter-permease
MSGARPWAGALRHFWVTLQLNSRSKQAIGYGYLLPVFFLLAFGSVFRGGEPLLLDQMGQLLTITILGTASIGLPTALVAERERGVWRRYRLLPVSTARLLAGTLLARLVIVVTAVALQVVLARLIYDTPLPQHPFSAFAALLVVTFAFLGLGLVVAALANDVPSVQALGQCLFLPMIMIGGVGVPLSVLPAWAQRVAGFMPGRYAVEALQSTFNAPAGLRREGFAVLALLVIGAAAAGVGLKLFRWDPLHRAGRTAGGWIAVALLAWLGVGLTASVTGRLAPIGAAGASYETITDEELEQIRFDDLTGDNELVTRLARPFDAAAAERIRPFLEKLHAWPPGQVTDPVQHARNLLSVAAIADVTADLQEAQIGRAVFDELQARYPRPQLRRILGWIILNPDGERVITATPELGLRREINERAVRQRSIFYAKKFLGRLLGKLPD

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Crispr_ID: NC_010571_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010571_5

4963328-4963418

Orphan

Consensus_repeat	Method
GCCATTTTCACGTAATACGTGAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010571_5

>merge|NC_010571|5|4963328-4963418|CRISPRCasFinder
GCCATTTTCACGTAATACGTGAAATTCTGTTGCGCCCGTCCGTGCCGGAGCGCGCGAGGGACGTGAGGCCATTTTCACGTATTACGTGAAA

>NC_010571|5|5|4963328-4963418|CRISPRCasFinder
GCCATTTTCACGTAATACGTGAAA	TTCTGTTGCGCCCGTCCGTGCCGGAGCGCGCGAGGGACGTGAG
GCCATTTTCACGTATTACGTGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_010571.1\|WP_012376627.1\|4964736_4968504_+\|carbohydrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|376716
NC_010571.1\|WP_012376632.1\|4975064_4976003_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|293742
NC_010571.1\|WP_012376624.1\|4962201_4962867_-\|hypothetical-protein	unknown	unknown	unknown
NC_010571.1\|WP_193372206.1\|4968990_4969758_-\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589
NC_010571.1\|WP_012376633.1\|4976208_4977345_+\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_010571.1\|WP_012376634.1\|4977428_4979093_-\|HDOD-domain-containing-protein	unknown	unknown	gnl\|CDD\|370050
NC_010571.1\|WP_012376622.1\|4959284_4960283_-\|bile-acid:sodium-symporter	unknown	unknown	gnl\|CDD\|372642
NC_010571.1\|WP_012376618.1\|4956573_4957818_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NC_010571.1\|WP_012376629.1\|4969890_4971153_-\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|173310
NC_010571.1\|WP_012376625.1\|4962975_4963245_-\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|274226
NC_010571.1\|WP_012376631.1\|4972461_4974915_-\|family-1-glycoside-hydrolase	unknown	unknown	gnl\|CDD\|200480
NC_010571.1\|WP_012376617.1\|4953247_4956421_-\|multidrug-efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|334294
NC_010571.1\|WP_012376635.1\|4979375_4979882_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_010571.1\|WP_158305487.1\|4959010_4959304_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379642
NC_010571.1\|WP_148218298.1\|4960470_4962003_-\|murein-biosynthesis-integral-membrane-protein-MurJ	unknown	unknown	gnl\|CDD\|240528
NC_010571.1\|WP_012376626.1\|4963578_4964556_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|223220
NC_010571.1\|WP_012376619.1\|4957935_4958172_-\|hypothetical-protein	unknown	unknown	unknown
NC_010571.1\|WP_012376630.1\|4971268_4972315_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|223135
NC_010571.1\|WP_012376620.1\|4958271_4958877_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_010571.1\|WP_012376616.1\|4952424_4953192_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|187620

Protein	Function_ID	Function_description	E-value
NC_010571.1\|WP_012376627.1\|4964736_4968504_+\|carbohydrate-binding-domain-containing-protein	gnl\|CDD\|376716	pfam02018, CBM_4_9, Carbohydrate binding domain. This family includes diverse carbohydrate binding domains.	4.67934e-13
NC_010571.1\|WP_012376632.1\|4975064_4976003_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|293742	cd16018, Enpp, Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin. Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.	8.59888e-45
NC_010571.1\|WP_012376630.1\|4971268_4972315_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	5.13666e-172
NC_010571.1\|WP_193372206.1\|4968990_4969758_-\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	3.65094e-150
NC_010571.1\|WP_012376633.1\|4976208_4977345_+\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	4.15746e-175
NC_010571.1\|WP_012376634.1\|4977428_4979093_-\|HDOD-domain-containing-protein	gnl\|CDD\|370050	pfam08668, HDOD, HDOD domain.	1.37504e-22
NC_010571.1\|WP_012376622.1\|4959284_4960283_-\|bile-acid:sodium-symporter	gnl\|CDD\|372642	pfam13593, SBF_like, SBF-like CPA transporter family (DUF4137). These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, pfam01758.	7.99406e-117
NC_010571.1\|WP_012376618.1\|4956573_4957818_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	6.34547e-68
NC_010571.1\|WP_012376629.1\|4969890_4971153_-\|phosphoglycerate-kinase	gnl\|CDD\|173310	PTZ00005, PTZ00005, phosphoglycerate kinase; Provisional.	0
NC_010571.1\|WP_012376625.1\|4962975_4963245_-\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|274226	TIGR02605, CxxC_CxxC_SSSS, putative regulatory protein, FmdB family. This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions].	6.98599e-19
NC_010571.1\|WP_012376631.1\|4972461_4974915_-\|family-1-glycoside-hydrolase	gnl\|CDD\|200480	cd11341, AmyAc_Pullulanase_LD-like, Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins. Pullulanase is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-and beta-amylase limit-dextrins of amylopectin and glycogen. Pullulanases are very similar to limit dextrinases, although they differ in their action on glycogen and the rate of hydrolysis of limit dextrins. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	9.55824e-92
NC_010571.1\|WP_012376617.1\|4953247_4956421_-\|multidrug-efflux-RND-transporter-permease-subunit	gnl\|CDD\|334294	pfam00873, ACR_tran, AcrB/AcrD/AcrF family. Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.	0
NC_010571.1\|WP_012376635.1\|4979375_4979882_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	3.11455e-08
NC_010571.1\|WP_158305487.1\|4959010_4959304_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	1.67287e-29
NC_010571.1\|WP_148218298.1\|4960470_4962003_-\|murein-biosynthesis-integral-membrane-protein-MurJ	gnl\|CDD\|240528	cd13123, MATE_MurJ_like, MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	6.65753e-127
NC_010571.1\|WP_012376626.1\|4963578_4964556_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	6.24955e-80
NC_010571.1\|WP_012376620.1\|4958271_4958877_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	7.84816e-14
NC_010571.1\|WP_012376616.1\|4952424_4953192_-\|glucose-1-dehydrogenase	gnl\|CDD\|187620	cd05362, THN_reductase-like_SDR_c, tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs. 1,3,6,8-tetrahydroxynaphthalene reductase (4HNR) of Magnaporthe grisea and the related 1,3,8-trihydroxynaphthalene reductase (3HNR) are typical members of the SDR family containing the canonical glycine rich NAD(P)-binding site and active site tetrad, and function in fungal melanin biosynthesis. This subgroup also includes an SDR from Norway spruce that may function to protect against both biotic and abitoic stress. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	8.33756e-89

>NC_010571.1|WP_012376625.1|4962975_4963245_-|zinc-ribbon-domain-containing-protein
MPTYEYACQKCGHTFEQFQSMHDAPLKKCPECKKLGLKRLIGGGAGLIFKGSGFYITDYKKKSGGDSGGEKPSTPKSESKADAKPAANK
>NC_010571.1|WP_012376624.1|4962201_4962867_-|hypothetical-protein
MNKKLERELHGPSWTEVILGAVLSLLLGVVLAAVYLVLKPVAAVKELPKEPATDVVYYLEGTRDLTKARQAAAKQKAFVQGGSVVLNEDELNTLLGLTPAVAKSEAEAAAAEKTITPGTPNFRIRDNVLQIGVPVQIKVLGFAQNVIVQARGGFAQRGDRWVFDPTEFYVGSCPLQRLPAVEGMLVKQVMAGATIPEDVAAAWQRLTGVAVEGSALRLTVE
>NC_010571.1|WP_148218298.1|4960470_4962003_-|murein-biosynthesis-integral-membrane-protein-MurJ
MVSLLTVVSRVLGLVRDQLGAAIFGASELNSAFITAFSLPNLFRRLLGEGSLTAAFVPTLQDELHERGRPGAFMLLNQVTSWLALITGALVVFAMVLFSQSRLLPGHESRWYLAADLAVILFPYLAMICIAAALNATLNVFEHFTEPALSPIWLNLAMIATLGGAGWHLATTELGQMYWLCAGVLIGGFLQLSVPAGVLVKMGWRPRFDFGLAPRVREIGALMAPGLFGTAIYQINVFVSRLFAFSIDEASATLLFYANRLMELPIGVFAIAVATVVYPLIARHATERNFAGMADDYRKGLRLILMINVPAAAGLALLSEPIVRLIYQHGEFTATDTRAMGPLLALFSVGMPFFSISSLTTRAFYALKDTVTPVKIGALSFVINVGLSWALKDWLGAPGLVLASTAAVIVQTIVMQRLLARAVPGLGFGELWRTIGKIVAATAAMSLVVFAGWAALRYAFAGNRTVDLIAIGGLIPVGVAVYAAVLWAVRVEGREEISAILARFRGKFGG
>NC_010571.1|WP_012376622.1|4959284_4960283_-|bile-acid:sodium-symporter
MRLKVDWFLAGMVAATALAWLFPEPGASGGWLYPDILTKAGIALIFYLHGLALSFGALKAGTLRWPLHVVVQVTTFLVFPLIGLGLITLLGERVSPELRLGLFYLCALPSTVSSSVALTAAAHGNIAAALFNATLSSVLGVFLTPLWVTVVLRSRGAAQPLGPVMLDLTIWLILPLILGQITRPLLGRWAERNKRVINKVDRLTILLLVYTSFCDSFQQGVWSHHGWATLALVLAIAAGLFTLVMAITGGVSRWLGFPREDRIAAMFCGSKKTLASGVPMARLIFGAHPGIGLILLPIMIYHPLQLVICGVLAQRWAHRTEDDDHGHARSTG
>NC_010571.1|WP_158305487.1|4959010_4959304_-|GNAT-family-N-acetyltransferase
MPAAPDDIAVTHNEAEQRFETQVQGELAVCEYQPEGRRWVFTHTYVPPELRGRNIAAKLVRTALEHARKQGVQIVPACSYVAAFIERNRDYQALVAQ
>NC_010571.1|WP_012376620.1|4958271_4958877_-|TetR/AcrR-family-transcriptional-regulator
MDAALELIWTQSYGAVTIDDICKRADVRKGSFYYFFDSKEQLAVAALERLWNDDWKPRMDEIFSASLEPLDRLKGYLAGVYRRQSETKKRTGRMLGCPVASVGSEMGTTECTICEKTREMVGRKRRYIEATVREAIANGSLEPGDPVKRTTVLMSFIEGLTLQARIMNDPEILKGLPELGLEILRVRAVQPELEPTPVPAL
>NC_010571.1|WP_012376619.1|4957935_4958172_-|hypothetical-protein
MNNTSHILSLSGLRSVHNARMRFYGVGRDPVFDSANPRQQRPFPGVGTPAGDRAAPPERLWRTDLLDRLEPPLTRYRE
>NC_010571.1|WP_012376618.1|4956573_4957818_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MSTASSTRSRPLPLRLRRPAFIIPTVLLGAALATYAVTHLTASEQAQAAPSAPPPPKVTVAPVERQLVTDYEELTGRVDSIETVDLRARVSGHIQDVRFQAGEIVHRGDVLFTIDPRWYRAEFDLALARADQARAQAEVADSEARRANELLAVAAVSTEEAEARRTRAHVARAAVASAEAALATARLNLEHTEVRAPIDGRISRALVTAGNLISGAPGGATLLATIVSTGEAYVYADIDESTLLKFNRLLRENRLALENGRVPVEMQLADESGYPRRGYIESTDNRLNPATGSLALRLVFANRDQALVPGLFARVRVPVGAPRPSLLVSERAIGTDQSQKFVLAVAADNKAVYRSVKLGGSFHDKRVIQSGLEPGDRVIVNGLQRVRPGMTVQPELLAAEATTQNANANRLASR
>NC_010571.1|WP_012376617.1|4953247_4956421_-|multidrug-efflux-RND-transporter-permease-subunit
MNLSDFFIKRPIFAGVVSTIIFLVGAISLWQLPVSEYPEVVPPTVVVRAVYPGANPKTISETVAAPLEQSINGVENSLYMSSQATSDGVMTLTVTFKVGTDLDNAQVQVQNRVAQAEPKLPEVVRRLGITTTKTSPDLLMVVHLFSPDNRYDDIYVRNYASLQVRDVLARLPGVGQVRIFGSGDYAMRVWLDPNKVAARGLTASEVVAAIREQNVQVASGAVGQQPNPNAISTELLINTQGRLTTEDEFGAIIIKTGAHGERVQLRDVARVELGAADYALRSLLNNKPAVALPIAQLPGSNAIATSDAVRATMTELKKNFPEGLDYSIVYDPTIFVRESIRAVVHTLLEAIVLVVLVVILFLQTWRASIIPLAAVPVSLVGTFAVMHALGFSINALSLFGLVLAIGIVVDDAIVVVENVERNIALGKTPFEATKQAMREVTGPIIATALVLSAVFIPTAFISGLTGQFYKQFAITIAISTIISAFNSLTLSPALSALLLRDHHAPKDWLTRGMDRSLGWFFRPFNRFFEWSARKYSHGVARLLRVSAVALLVYAGLLAFTALSFRKIPTGFVPSQDKQYLVAFAQLPAAASLERTDAVIRRMSEIALNHPGAQNAIAFPGLSINGFTNSPNSGIVFVALKPFEERRSAELSGQAIAQQLQQQFGEIQDAYIAIFPPPPVQGLGTIGGFKLYVEDRGDHGLDALYAATQGLVAQAAQTPVLTRVFSGFTINTPQLQADVDRAKAKSQGVPLQNVFETMQINLGSLYVNDFNRFGRTYQVIAQADAEFRQKPDDILRLKTRNAAGQLVPLGAVVNVSETYGPDRVVRYNGYPAAEINGAPAPGFSSGQAEAAMEQLARDHLPTRMALDWTELTYQKIIAGNTGVLVFPLSLLLVFLVLAAQYESFRLPFAVLLIVPMALFSAMVGLWLTHGENNVFTQIGLMVLIGLAAKNAILIVEFALKRREEGESVVQAALDAARLRLRPILMTSIAFIAGVFPLVVSTGAGAEMRRAMGVAVFAGMIGVTLFGLFLTPVFYVVLEKLGVRKPAAAAAPLPAPQSA
>NC_010571.1|WP_012376616.1|4952424_4953192_-|glucose-1-dehydrogenase
MSTHTKPKLFGKVALVTGASKGIGASIALHLGEAGAAVVVNYTSSREGAERVAGQITQHGGRAVAVQADVSKRADIDRLFAETIAAFGRLDILVNNAGVYDFAPLGQITEAHFHRHFDVNVLGLLLATQKAVDHFDEHGGVIINVGSIVSTFALANGSGYSATKAAVDAITRSLAKELGARRIRVNSLNPGAVDTEGSRAGGIIGSDFEKQIIQDTPLGRTGQPDDIGRVAVFLASGDSGWITGETIAVAGGHPH
>NC_010571.1|WP_012376626.1|4963578_4964556_+|polyprenyl-synthetase-family-protein
MDFAAELRRLTSLVEEGIERHLPPAATRPGRLHEAMRYSLQAGGKRLRPVLLLASAELCGGSGHSPSLQQSATPEPPAGRRGDLVTALALPAAVAIECLHTYSLIHDDLPCMDDDDLRRGRPTAHKAFDEATALLAGDALLTHAFALLAENYASQPALAMALIRELADAAGSRRLIGGQMEDLLAEKKADATAEELEFIHLNKTAAMIEASLVMGGWIGLHAQTAAPGALPPEITALRAAGRHLGLAFQIIDDVLDATADRATLGKTPGKDARAGKTTFVSLHGLDRSRQFAREHTAAARQALASLEREHAFLDALIDSLVTRAK
>NC_010571.1|WP_012376627.1|4964736_4968504_+|carbohydrate-binding-domain-containing-protein
MLRTRLLSISLLLALTCSVASAALESFTLPWNDATPGITNLQTWQPTPAGDAGWVSVTAGGHYVVGGERIRFLGVNVADLSCFPTHAQAEGHAARLARFGFNAVRFHHMEAQWAKDSVIIDYSLGNSRTLSADRLERLHYFVAQLAARGIYSNINLLVSREFQAGDGLGPEITQLEWKDQHILGFFMDEALQLHKEHATKLLSAPNPYRGGRSLAEDPAVSFVEIMNENGLLQKWYENVLDTLPTPYRSALQAKWNAWLKTRYATTAELLASWGTIDQPLGANMLANGDFAAGTGSWNFEQHNGAVATRIAGTEFNGQPSLRIAVTTPGSAGWHIQLNQAGLAFTSGKTYTVSFSAKAAAATPLSCSLTRTGPSDYSGVGSSISTTLGTSWQRYTFTFQAANDEPSVRLNFNGFGDRLCTVYLADVRFSEGGKIGGLADGVTLEAGNIPNVLHNAAAGSATAGQTRDWITYVFAAEKVYWDAMKAHIKDTLGYRGIVWGTIISNSPPNAQSSLDAMDSHAYWQHPVWPAGKDWDPVDWTISNVSMVNSPSSNTLTGIARQRVEGRPHNVTEYQHASPNTYASETPLLAAAFGALQDWDSLWMFAYDTNTDAAVSGFFDHGGHSGKMVNQLLAATLFRRGDVAPANLSYTLPFTPAQEVEAARASGAAWSIADGSKIGMPALMTSQSRVALSIGATATGLASPPATPTGSVFTADTGELRWDTSVANKGVVTVNTPRTKAVIGFTAGRSFDLGGVVIAPGTTRQDWSTIGLSLLEGYQFDQAGAARAVLVATGDQENTGQTWNTAKNSIGNRWGTSPVLVEVVPATITLPVAATRVSVWSLDETGQRKVAVSVRDAAGRAQFDLGRSGTTLWYEIAIEAGPVTAAAIASQPAPARSSILGGSVTLALSANGSPAPAVQWTRNGSDVTRLAAPVVTLENLQPADAGIYRARVSNASGSVLSEPMILGLTSSSKVVGAGHEVGSNIYVASNGNTFDQVLLEGAAAAITADHALNQITRLSYIDLDNDIVQVEMSGPGTLSLVLDSATGPAAPVNYNQSNVGYMKGHAGIVITGADERTNVSAFTVGRFTAFDPTGTFDVTKPVTDLNHPSKNGSPLFAGQADTAYDGIADLAFIAIASTDGRFGGVRAANANFFATKGLTGVYAPGVTFSGPVYVGDIIASDDSTPVLRLGAASNTRITGGDLLQANGAPVQVSGITQLVFADGSDSHGRLLPAQRNQAVLQENGVDVTATIVVNPTP
>NC_010571.1|WP_193372206.1|4968990_4969758_-|triose-phosphate-isomerase
MPRKKLIAGNWKMNKTPADGVALVKEIVAAAGKNNDVDMVVCPPFVAIESVGKALEGSNVKLGAQNMHPEASGAFTGEVSAPMLRAVFATHVILGHSERRAYFAETDAFINKKVLAALKNQLKPILCVGETLAEREAGSTLKVVQTQLEGGLEGVSKEQAATVVIAYEPVWAIGTGKVATTDQAQEVHAFIRGLLVKLFGDAIAAKVRILYGGSMKPSNAPELLAQKDIDGGLIGGAALEARSFLELINAAAAIK
>NC_010571.1|WP_012376629.1|4969890_4971153_-|phosphoglycerate-kinase
MAKFKSIRDLKLAGQRVFIRVDFNVPQDKATGAITNNARIVAALPTINYALEQGAAVVLASHLGRPDGKKIAKFSLKPVADELAKLLNKPVKFLDDCVGPAVEAACAKGTLKAGEVVLLENLRFHIEEEGKVKEKQPDGTEKSVKADPKAVEAFRASLSKLADVYVNDAFGTAHRAHSSMVGVQLKDKAAGFLMQAELEAFAKVVDNPARPLLAILGGAKIADKIPLINNLIDKANAIIIGGGMAFTFKKVLENVEIGASLFDPEGAKIVAELAAKAKAKGVKLVLPVDYVAGDKFAADAATKVVDDKAGIPAGWMGLDVGPKTNELFRQEILASKTIVWNGPAGVFEFDAFATGTKTQADAIAEATKAGAVTVIGGGDTATAAKKFKVAKVVTHCSTGGGASLELLEGKTLPGVAFLTA
>NC_010571.1|WP_012376630.1|4971268_4972315_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MAVKVAINGFGRIGRLVFRALVEQGLLGSTFDVVAVGDIVPADNLAYLLKYDSTQGKFNGTVSSKKSAADKAEDDVLVVNGHDIKVVSAKTPAELPWAAMGVQLVIESTGLFTAAEKAQGHITAGAKKVIISAPAKGEDITVVMGVNDDKLDVKKHNIISNASCTTNCLAPVVAVLLKEGFGVEEGLMTTVHAYTATQKTVDGPSKKDWKGGRTAAQNIIPSTTGAAKATALVLPEVKGKLTGMSLRVPVPTVSVVDLTVRTTKETSYKEICEAMKRASETYLKGILGYTTDEVVSSDFIHDKRSSIFDAGAGIELNSKFFKLVSWYDNEWGYSNRVVDLTKKIAAAL
>NC_010571.1|WP_012376631.1|4972461_4974915_-|family-1-glycoside-hydrolase
MASPGYRIIRAWLESLTSGVVELDRDWLGARPPQFSMGQQCPVLGGLAPASRRITGSAFGYRVEGNDIVFVLPELQCAGVDVERDGVYLGGDFNGWQQAVGLAEWRMQRSELEGESVLSWSGPAARFFDPAGQRFKFVTGEHQWLSVPDDAANAVRDADGNINRAIDPARTGRHLWSFVCPAPLDLAESLVIGWAAELTPPATPLVPGRFFYQLKTDLPLGALVREGETVFRLFAPRARSVTLFISPNRAGLKSPQQVPLARRPDADGRAGVWEVALNQRLHGWFYWYVIDGVREGRGAFDPTQRVLDPYALAALGREGPGIVLDRAWVGQGDRGFRTPAWQDLVIAEAHVRDLATHAPVPMTPAERRGFSGLRRWVEHPEFYLHRLGVNCVELQPVHEFDNHPHDHYHWGYMTNSFFSPESSYALDPAEGSAVRELQDLVRAFHGRGMAVLLDVVYNHVGVPPHLMFIDRLYYFEQHADGRLVDWSGCGNDLRANSAMARRLIIDSCVHMIEAYGVDGFRFDLAELLGVEVLREIEAALKRVKPDVVLIAEPWSFRAHIASRLRDTGWASWNDGFRDFLRKYVRGEGDARRMEYFLKGSPWYFAKWPAQTVNYTESHDDRTWIDMITEHHGYDGFAPTRRDVQRTHLMAALLFMSVGIPMLAAGQDFLRSKRGVSNTYLRGDLNALDYRRLFRYPGTHSYFAEWIAFRRSWLGRLVRHYERVSDAFFQFFHLDGAPAFAVVYNADRSLGPERLLFAVNPTQADLIVPLDEATAGAGWRQLANRERFINPQTPGATQPVEPALFVSALGCGLWVSDS
>NC_010571.1|WP_012376632.1|4975064_4976003_-|alkaline-phosphatase-family-protein
MTLSLFRRPRLLAWGSVFLLALTAAAARSAALPQRPIPAIEYVMVVSIDGMRPDVALLADTPTLHALVREGAYTFWAKTTAVSITLPSHVSMLTGVTPGRHGIMWNKELPFAEPVYPAVPTIMELATRAGYTTALVAGKPKFAALNKPGTITYSWIQPKTATDAQVATAAVEIIEQHQPAFLMVHFPAVDGVGHDFGWGSPEQRERLEQTDREFKRVLDALDRTNLRAKTLVLVTADHGGTGLTHGAEDPRSRHIPWIVAGPGVRRFYDLTRVENLEVRTEDTFATVAYLLGLPLPEKIDGKPVRAAFTDAR
>NC_010571.1|WP_012376633.1|4976208_4977345_+|tRNA-2-thiouridine(34)-synthase-MnmA
MPGAEKILVAMSGGVDSSVAALLLKQQGYDVVGAYMKNWINEDQVIGHCPWQQDIEDARRVATQIGIEFRVVNLMREYRERVVAYLLDGYARGLTPNPDIMCNREVKFGVFRSWAKDHGFAAIATGHYAQRVEVKPDLVTPAVLGGLNADGTPASTFALLEGADKNKDQSYFLALLSQEQLRDARFPIGHLPKPELRRIAREAGLATADKKDSQGICFIGEVKMQDFLRAYVPDAPGPIVRATDGRELGQHRGLHFYTLGQRKGIGIPSNTDHEAYVVVGKRAADRALLVAFDHPDAPGLFQREVRVHALSWIGKPVTTARALEGRVRYRDPRVPLEFVPESETTALIRFAAPQRGLAAGQILAFYDGERLLGGGVYA
>NC_010571.1|WP_012376634.1|4977428_4979093_-|HDOD-domain-containing-protein
MRGVLARGSHRLATVSTVAEAWSFIQRNVAVDLVFLELKLEGENGIGLLQRLRADCFLKVIPVVIYTAAGDRDVVRQAMQLGVQNFLVKPYRDDYILAEVGKALANPWRNQHFEEEKSFCAMTGLTPDGLRAALKEVHASLQNIGPELLEHIKGENAPGAIGTIENTTTKGEAAGAWGIVELLNEVKGLVEQGLWPAAGGALSQLGFAERLIFAHLNPAVVPEDFVSPEERAKAEEARARAVWFNAEAEQRVPVVAWPQLQQQLDGLKGCPVVDSVAAAFQMAATGHPSSLAPLMDIAEKDPGLSAQLIVAANQVRKGENEPDHEPVENPRICVGLLGEIRLAAMASSLVRVDERYMDMPPCSWTSFWMFQVGVARMARYTCRYLEFHSLESRAYAAGLLHDIGKLLLLRLHPYGFQAIVDFARRRSVPIAAAEKFFLGCTTAEMGAYFAEKREFPASYGVVMRFVETPEAATEDAVLVASVSLARDLCRQNRVGWSGDPNVGGVKPIAETAGWQVLSGRVFPSFNLQKFETEAHAECRQLKRELHGQVHLPQL
>NC_010571.1|WP_012376635.1|4979375_4979882_-|tetratricopeptide-repeat-protein
MKFLVLISLALALALTGGCKPKPKEIPALQRKEAANLASEAQFAVALRDYARAEPLFEKAAKLCPDQGDYWVNLGVARKRQGNTAGAKQAYESARKAFHDAFELDEKNTDAALQEVYTLALLGRADDARKTLERVRKQAPDDREIRLFIENKQLDRILEDPAFKDIAL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

5640733 : 5675492

Acanthocystis_turfacea_Chlorella_virus(33.33%)

holin,integrase

attL 5652069:5652128|attR 5681499:5686588

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_158305507.1\|5640733_5641135_-\|holin	phage holin family protein	NA	NA	NA	NA
WP_052300461.1\|5641189_5641777_-	hypothetical protein	NA	NA	NA	NA
WP_012377147.1\|5642022_5644149_-	DEAD/DEAH box helicase	M1HBX1	Acanthocystis_turfacea_Chlorella_virus	1.3e-31	27.7
WP_012377148.1\|5644464_5645148_+	choice-of-anchor K domain-containing protein	NA	NA	NA	NA
WP_012377149.1\|5645256_5646303_+	SIS domain-containing protein	NA	NA	NA	NA
WP_012377150.1\|5646485_5648003_+	DUF1846 domain-containing protein	NA	NA	NA	NA
WP_012377151.1\|5648603_5650016_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012377152.1\|5650185_5650803_+	hypothetical protein	NA	NA	NA	NA
WP_012377153.1\|5650805_5651831_+	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_083767816.1\|5651893_5652025_-	hypothetical protein	NA	NA	NA	NA
5652069:5652128	attL	NA	NA	NA	NA
WP_012374039.1\|5652241_5653540_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012374040.1\|5653543_5654536_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012374041.1\|5654508_5655519_+\|integrase	site-specific integrase	A0A2D2W391	Mycobacterium_phage	3.6e-08	25.7
WP_012374042.1\|5655515_5655920_-	heavy metal-responsive transcriptional regulator	NA	NA	NA	NA
WP_012374043.1\|5655968_5656559_+	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_012374044.1\|5656564_5657053_+	copper chaperone Copz family protein	NA	NA	NA	NA
WP_052300462.1\|5657105_5657456_-	JAB domain-containing protein	NA	NA	NA	NA
WP_012377154.1\|5657793_5658372_+	hypothetical protein	NA	NA	NA	NA
WP_012377155.1\|5658390_5660103_-	DUF2326 domain-containing protein	NA	NA	NA	NA
WP_012377156.1\|5660093_5660321_-	hypothetical protein	NA	NA	NA	NA
WP_012377157.1\|5660307_5661273_-	SMEK domain-containing protein	NA	NA	NA	NA
WP_012377158.1\|5661505_5661706_-	hypothetical protein	NA	NA	NA	NA
WP_012377159.1\|5661881_5662733_-	DUF945 domain-containing protein	NA	NA	NA	NA
WP_083767880.1\|5662631_5663144_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012377161.1\|5663591_5665097_+	B12-binding domain-containing radical SAM protein	NA	NA	NA	NA
WP_012377162.1\|5665117_5666113_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_012377163.1\|5666109_5667009_+	inner-membrane translocator	NA	NA	NA	NA
WP_012377164.1\|5667005_5667764_+	ATP-binding cassette domain-containing protein	G3M9Y6	Bacillus_virus	6.5e-10	26.5
WP_148218209.1\|5667709_5669716_+	hypothetical protein	NA	NA	NA	NA
WP_012377166.1\|5669690_5671205_+	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_012377167.1\|5671268_5671496_-	hypothetical protein	NA	NA	NA	NA
WP_012377168.1\|5671890_5672187_-	hypothetical protein	NA	NA	NA	NA
WP_148218210.1\|5672978_5673257_+	hypothetical protein	NA	NA	NA	NA
WP_012377170.1\|5673261_5673624_+	hypothetical protein	NA	NA	NA	NA
WP_012377171.1\|5674079_5675492_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
5681499:5686588	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_010571

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection