CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NC_012527	Deinococcus deserti VCD115 plasmid 1, complete sequence	2 crisprs	cas3	7	0
NC_012526	Deinococcus deserti VCD115, complete sequence	1 crisprs	cas3,csa3,DEDDh,DinG	0	2
NC_012528	Deinococcus deserti VCD115 plasmid 3, complete sequence	0 crisprs	csa3	0	0
NC_012529	Deinococcus deserti VCD115 plasmid 2, complete sequence	0 crisprs	csa3	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_012527_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012527_1

306582-306801

Orphan

Consensus_repeat	Method
CTCCACGACACACCTGAGCGATT	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_012527_1

>merge|NC_012527|1|306582-306801|CRISPRCasFinder
CCCGACGACACACCTGAGCGATTTCTTCTCATAGGTCGCTGTGAATCCTTCCCAACATGACTCAGCAACGACATACCTGAGCGATTCAGTGTAAAGACACCCTCCTGATGAGGTGAGTTCTCGGCTTTGATCAGCGACACACCTGAGTGATTTGTACGAAACGGTTCTGTTGGACGGATACAAACCACACGGGCATACCGACGACACACCTGAGCGATGA

>NC_012527|1|1|306582-306801|CRISPRCasFinder
CCCGACGACACACCTGAGCGATT	TCTTCTCATAGGTCGCTGTGAATCCTTCCCAACATGACTC
AGCAACGACATACCTGAGCGATT	CAGTGTAAAGACACCCTCCTGATGAGGTGAGTTCTCGGCTTTG
ATCAGCGACACACCTGAGTGATT	TGTACGAAACGGTTCTGTTGGACGGATACAAACCACACGGGCAT
ACCGACGACACACCTGAGCGATGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012527.1\|WP_012694762.1\|307376_308738_+\|plasmid-replication-initiator-protein	unknown	unknown	gnl\|CDD\|370826
NC_012527.1\|WP_162485672.1\|295719_296504_+\|IS5-like-element-ISDds9-family-transposase	unknown	unknown	gnl\|CDD\|379129
NC_012527.1\|WP_012694770.1\|317570_318206_+\|LexA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224885
NC_012527.1\|WP_012694754.1\|297106_297571_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_012527.1\|WP_012694763.1\|308972_310607_-\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213027
NC_012527.1\|WP_012694756.1\|298848_300375_+\|sensor-domain-containing-diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_012527.1\|WP_162485671.1\|294587_294839_-\|hypothetical-protein	unknown	unknown	unknown
NC_012527.1\|WP_012694767.1\|315046_315979_+\|alpha-E-domain-containing-protein	unknown	unknown	gnl\|CDD\|377234
NC_012527.1\|WP_162485673.1\|301667_302414_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NC_012527.1\|WP_012694761.1\|304611_305760_+\|diaminopropionate-ammonia-lyase	unknown	unknown	gnl\|CDD\|236186
NC_012527.1\|WP_012694760.1\|303456_304590_+\|ArgE/DapE-family-deacylase	unknown	unknown	gnl\|CDD\|349935
NC_012527.1\|WP_012694757.1\|300641_300974_-\|hypothetical-protein	unknown	unknown	unknown
NC_012527.1\|WP_012694771.1\|318208_319480_+\|Y-family-DNA-polymerase	unknown	unknown	gnl\|CDD\|176458
NC_012527.1\|WP_012694753.1\|296509_296881_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378504
NC_012527.1\|WP_012694766.1\|313244_315047_+\|circularly-permuted-type-2-ATP-grasp-protein	unknown	unknown	gnl\|CDD\|225190
NC_012527.1\|WP_012694768.1\|316006_316852_+\|transglutaminase-family-protein	unknown	unknown	gnl\|CDD\|224224
NC_012527.1\|WP_012694769.1\|316929_317370_-\|response-regulator	unknown	unknown	gnl\|CDD\|381108
NC_012527.1\|WP_012694755.1\|297941_298355_+\|hypothetical-protein	unknown	unknown	unknown
NC_012527.1\|WP_162485674.1\|311563_311857_-\|hypothetical-protein	unknown	unknown	unknown
NC_012527.1\|WP_162485690.1\|312053_312857_-\|transglutaminase-family-protein	unknown	unknown	gnl\|CDD\|224224

Protein	Function_ID	Function_description	E-value
NC_012527.1\|WP_012694762.1\|307376_308738_+\|plasmid-replication-initiator-protein	gnl\|CDD\|370826	pfam10134, RPA, Replication initiator protein A. Members of this family of bacterial proteins are single-stranded DNA binding proteins that are involved in DNA replication, repair and recombination.	1.38987e-16
NC_012527.1\|WP_162485672.1\|295719_296504_+\|IS5-like-element-ISDds9-family-transposase	gnl\|CDD\|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	2.92037e-26
NC_012527.1\|WP_012694754.1\|297106_297571_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.17427e-25
NC_012527.1\|WP_012694763.1\|308972_310607_-\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213027	cd10970, CE4_DAC_u1_6s, Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel. This family contains uncharacterized prokaryotic polysaccharide deacetylases. Although their biological functions remain unknown, all members of the family contain a conserved domain with a 6-stranded beta/alpha barrel, which is similar to the catalytic NodB homology domain of rhizobial NodB-like proteins, belonging to the larger carbohydrate esterase 4 (CE4) superfamily.	1.80734e-64
NC_012527.1\|WP_012694756.1\|298848_300375_+\|sensor-domain-containing-diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.67857e-37
NC_012527.1\|WP_012694767.1\|315046_315979_+\|alpha-E-domain-containing-protein	gnl\|CDD\|377234	pfam04168, Alpha-E, A predicted alpha-helical domain with a conserved ER motif. An uncharacterized alpha helical domain containing a highly conserved ER motif and typically found as a tandem duplication. Contextual analysis suggests that it functions in a distinct peptide synthesis/modification system comprising of a transglutaminase, a peptidase of the NTN-hydrolase superfamily, an active and inactive circularly permuted ATP-grasp domains and a transglutaminase fused N-terminal to a circularly permuted COOH-NH2 ligase domain.	1.47854e-103
NC_012527.1\|WP_162485673.1\|301667_302414_+\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	1.29015e-07
NC_012527.1\|WP_012694761.1\|304611_305760_+\|diaminopropionate-ammonia-lyase	gnl\|CDD\|236186	PRK08206, PRK08206, diaminopropionate ammonia-lyase; Provisional.	7.46181e-120
NC_012527.1\|WP_012694760.1\|303456_304590_+\|ArgE/DapE-family-deacylase	gnl\|CDD\|349935	cd08013, M20_ArgE_DapE-like, M20 peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases. Peptidase M20 family, uncharacterized protein subfamily with similarity to acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE) subfamily. This group includes the hypothetical protein ygeY from Escherichia coli, a putative deacetylase, but many in this subfamily are classified as unassigned peptidases. ArgE/DapE enzymes catalyze analogous reactions and share a common activator, the metal ion (usually Co2+ or Zn2+). ArgE catalyzes a broad range of substrates, including N-acetylornithine, alpha-N-acetylmethionine and alpha-N-formylmethionine, while DapE catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelate (L,L-SDAP) to L,L-diaminopimelate and succinate. Proteins in this subfamily are mostly fungal and bacterial, and have been inferred by homology as being related to both ArgE and DapE.	0
NC_012527.1\|WP_162485690.1\|312053_312857_-\|transglutaminase-family-protein	gnl\|CDD\|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	8.66526e-35
NC_012527.1\|WP_012694771.1\|318208_319480_+\|Y-family-DNA-polymerase	gnl\|CDD\|176458	cd03468, PolY_like, DNA Polymerase Y-family. Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.	1.77647e-11
NC_012527.1\|WP_012694753.1\|296509_296881_+\|hypothetical-protein	gnl\|CDD\|378504	pfam10882, bPH_5, Bacterial PH domain. This family of proteins with unknown function appear to be related to bacterial PH domains. This family was formerly known as DUF2679.	0.000577089
NC_012527.1\|WP_012694770.1\|317570_318206_+\|LexA-family-transcriptional-regulator	gnl\|CDD\|224885	COG1974, LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms].	2.67431e-35
NC_012527.1\|WP_012694768.1\|316006_316852_+\|transglutaminase-family-protein	gnl\|CDD\|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	1.11242e-52
NC_012527.1\|WP_012694769.1\|316929_317370_-\|response-regulator	gnl\|CDD\|381108	cd17557, REC_Rcp-like, phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains. This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	4.93292e-40
NC_012527.1\|WP_012694766.1\|313244_315047_+\|circularly-permuted-type-2-ATP-grasp-protein	gnl\|CDD\|225190	COG2308, COG2308, Uncharacterized conserved protein [Function unknown].	0

>NC_012527.1|WP_012694761.1|304611_305760_+|diaminopropionate-ammonia-lyase
MTTQTDQPRFYFNPAVQTFAAAVEPEVLEFHRKLPGYLPTPLVRAPRLAEALNVAEAWVKDEASRLGLPAYKILGASWATYRELDTRFGPFRPWQSLAELAAQLSPHRPLTLVAATDGNHGRAVARTARWLGLAAHILVPEDMVRARIQAIEEEGAQVQIVRGSYDDAVEASARLADAAHLVISDTAWDGYTRVPGWVIAGYSTIFQEIDAQLAQQGARPPHLVAAQMGVGSLAAAVVGHYRTPARQTQVAGVEPTRADCVLRSLEAGRPTEVPGPHTSMMAGLNCGNTSPLAWPLLQGGLSASMAIPDERAEQAMRLLAQDGVTSGESGAAGAGGLLELLAGSQAQASRRTLGITPQSTVLVISTEGATDPAAYARIVPTS
>NC_012527.1|WP_012694760.1|303456_304590_+|ArgE/DapE-family-deacylase
MTQSLQDLLAALVRINSINPSLVPGAAGEAELATFVAGWLQDHGIEAVIDEAAPGRLSVIGTVRGTGGGRSLLLNAHLDTVGTDHMPEAFNPVVRDGRMYGRGTYDMKGGLAACLFALLDAREAGLRGDVILAAVADEEHASLGMQSVLKTVRADAAIVTEPTSLQLCVAHKGFTWHEITTHGRAAHGSRPDLGTDAIAHMGRVLVRLEALQRELEERPPHPLLGHASVHASLITGGQELSSYPERCTLQIERRTLPGETRDEVEQEWTALLGELAQDPQFHAEHRITLLREPFGVSEEAPIVQVLHAQAAQVLGEAPQHIGQTFWMDAAFLAGAGIPTVVFGPHGTGAHATEEWVDLASVEQCRAVLSATVRAFCA
>NC_012527.1|WP_162485673.1|301667_302414_+|universal-stress-protein
MTSPGFSPLTYLVPLDGRVGPTWVTEQAIELASAHGGTVLGLSTLKGPEAQNDLHSFQERCRVTGIAARSLHLPGPRFQGIMEASKRADLVMVAWTAESARVLDFSTFGALVRHATCPVWIAPPSGRVPAELTVAFHGQRKAFHAIAQAAKLAQTWQLPVDTLVVAEGPDINDHDTLIARQELRARNVIERHSRYERGVTGEILAAATSPDQLLIMGGAGDGPFFGLTLSRIVRQVLRLPRGPVLICP
>NC_012527.1|WP_012694757.1|300641_300974_-|hypothetical-protein
MDLPAAKQVVQQIINDLSLPDGTRLGVDVDANPDRLNIIAISGRRAGVVVITKEALEDHGHKAINAAIERLRRAIYDKDLPLLTGAPVQLGMLDSRGWTDGSVSPYSNDS
>NC_012527.1|WP_012694756.1|298848_300375_+|sensor-domain-containing-diguanylate-cyclase
MPSAPLPEQEYARLLELARYNILDTAPEESFDRLTRLAARTLRVPGVILNFVDQGRQWRKSWFGDGETNCSREDSFCAWTILSDDVLAVSDAREDPRFHDYKLVVGDPNIRMYAGAPLVTPSGHRIGSLCVFSAEARELDLDDQATLRDLAALVMDELELRLHNHVLQSQINQQDQQLWELRQTVAHAQVLEDINGLTETATTPEEVTLAVAAKIGEAIHADWTGLIAFSGNDATIQVAHHQPDLSPALLAFASRLPQLPCGVTRGMRGVTHTAYIEDYRQHPDALQEGVDAGFKSAALVPLGQYGEIEFLLIAARAERGSRAAWRSSDRALLDAAGRTVRAALVRRAALEASLLAARQDRLTGIANRRAFDHDLELRMQAGQPFTFALMDLDGFKQVNDVEGHAQGDRVLQVFALALRDTVSSYGQVYRYGGDEFALLLDPLTDERALEHVDSAVLAARQVTTRFVGASVGIVQMGNEDNPYCPSELQQRADTRMYEVKRRRQAALN
>NC_012527.1|WP_012694755.1|297941_298355_+|hypothetical-protein
MRQQDSRTDDHQTQFANALKQLMVAHGLGSVRARGDSGFLGLTPAGKFETTDLAFKFMAPDEHLAAAQALGLPAPQIGPSGRSARPQDMERFVRATGQLFDEYGVMNLEFTREALLGFRKTGHTVDFVVEGITLTLR
>NC_012527.1|WP_012694754.1|297106_297571_+|MarR-family-transcriptional-regulator
MTQNLTKPALPKVTLDLEDQLCFDLYAAARLITSAHRPFLLPLNLTYPQYVVMLTLWQHGPQTVTELGEYLHLDSGTLSPLLKRLETTGYVTRSKSALDERATIIELTPAGAALKERVTDVPSAVACQVGLKPEEKQKMQEQLRAMIARLSGDR
>NC_012527.1|WP_012694753.1|296509_296881_+|hypothetical-protein
MESVAIGLILLTLPPLLYIVSQKTGVRYTWTPDALQVDTGLRRYIFPYATTTARLTTQPLGSRIWGTAVSGSVTGRYTLDSSTVQALATTARPAQALLLEAGQQTFYVTPERAEEFAARFLAK
>NC_012527.1|WP_162485672.1|295719_296504_+|IS5-like-element-ISDds9-family-transposase
MMRLTDQQWTVLAPLLPRPVKRTRRGRTRQPDREVLEGILWILRTGAQWDALPKGEYPSKTTCHDRFQEWNEQNVFPTVLSALYELGEEEHLLDLREAFIDGTFSPAKKGARTSGQPKKGKGTKVMIMVDASGVPLAVHTSSASPAEVTLVHDTLEASFGMDFPKRLIGDKAYDSDGLDVELETLGIEMIAPNRRNRKKTQDGRPLRRYRRRWKVERTIAWLQSFRRVRTRDEVKAQNFLGMVQLACIVILLRLVTSPPVP
>NC_012527.1|WP_162485671.1|294587_294839_-|hypothetical-protein
MEMLFTAVVVGIGLLDLLLYLFIPRRVPPPTCQLTLKHPPRKSVPASAWERKIVTSVHEVISEPRHPGIPSGRNIPAHPEVNF
>NC_012527.1|WP_012694762.1|307376_308738_+|plasmid-replication-initiator-protein
MTSPPSRFDELNLSRLNLISAVDQAEVSEWDVTFEAHGRIVHVRCEALPKYAVPHGLDSDVTAALINLYIELGEPEDGRFSVSATTLLKLCGWHNTGKYHGILRVCLERLHTSSYSVSGGWRDHPKGRWTHAKFHFIESLDFSSSDGAGAFDDRTIIAGRLADVIVASIRSGYVKPLDTEFMLSLSRPRTRALYRILDGARYDPDHPDVRLDTLEFNLIQWADQCKIPSTIPGNIRRALASPHEELIKRGYLRAATLSGRGKDQRVRYEFVREFVAMDAVLARRFRSYGVADGVARKLLVEHGRDALIASMDRFDGLVRQGVLVVKKTPAAALMHLINHPDDYPYPKGAPAAPAPVRPARVEPVMEAPSVEAEFASLSLEQAAERLISRMNVHYRKLLSVSDLDTLRQAVMKELLSPSAVLEEATAAVVKLQRENFAQTLRARLGLPEERPIK
>NC_012527.1|WP_012694763.1|308972_310607_-|polysaccharide-deacetylase-family-protein
MKPYLSPAALILTALLSACSTDSSTPTATEDTTAISELGTFDAAFTNPQGGTMRSLSASVALQPATPLGAVDIRVAGSGMYDDERSNRRYLWGVFEVTNTSKTNLSNLTMVAYTKAGASIGGTAITRLQDAQGRAYLNERVAQNIRPGDHLNILNSYAFQGLTEDEAQRIETGARTGKLIGTNDDVLEYGFTVINPRDGSQTLRPGETGTLVLATKLPLLAGNAPQKFNMSLLLTTGGARRVTRNVGESNESVHLRARLSGAREIAYIGPDTNTAPGRYRTVRIPNIRLTTGAKPTYLLDLEEKLSSCVQGLQPTGLRPLNNAGPMVTFITDDGAAADHSRLLPLFKQKGVVATAAIATQNIISGDPYFATPEQVRDLQRAGWEIASHTRTHPDLVTLSDAELSAEIEGSKRELEDLGFRADTFVYPYGSHNPTVREKVCQHYRTAFIDRGGANDTPLNTNYQLRRVAFGAWTDAGQNTMDAYKAAVDSAIARNSWLVFMLHPGNREQHNEQQQQYLADTIDYVRGKNVPIVTAGDALYRLGAK
>NC_012527.1|WP_162485674.1|311563_311857_-|hypothetical-protein
MKIRHDRDAGRGRVLSSECLTIDEGTTVRIVKHEASGGQLCHYELLDEETGLMYTAECGTGEGRYDDVYTYRVQEPGIRVGSQSMGQVMGTKTSGTR
>NC_012527.1|WP_162485690.1|312053_312857_-|transglutaminase-family-protein
MLFVVEPQNRPGQQIVQTREYLDPSAGVGRWSRYTDVFGNSIWRVLGVGHTLQVGQDVIVQVPAHSDPQHPDLPKTPVEDLPDEVLQFLLPSRYVDSDLISNEAWERFGHIQGGWAQVQAISHHLYSTCSYGAASTSSTTAQQAYQSGRAVCRDFAHMGVAFCRALNIPARYVCGYLGDIGVPSTDTPMDFHAWFEAWIDGAWRTFDARHNKPRTGRVLIATGRDAADVAFTTSFGAARLTRMQVWADQVDPGFTLPDTWAPPQPRA
>NC_012527.1|WP_012694766.1|313244_315047_+|circularly-permuted-type-2-ATP-grasp-protein
MEQYDQGTTFFDEMFTPQGQVRPHYQGVLSYFRRLGTTEFQRRQALMDLAFRNQGITFTVYGDSAGVERTFPFDPVPRIIPASEWSALEAGLKQRVKALNAFLRDVYSDGQILKDGIIPRELVYTSSNFRREVHGLQVPLGIYTHIVGSDLIRDEQGRYLVLEDNLRSPSGVSYLLANRQAMTRIFPGMFERQGVRTVDHYTTALLGVLSSLSPRAPEATVVVLTPGMYNSAYFEHAYLAQQMGVELVEGRDLFVDGGRVWMRTTSGRTQVDVIYRRIDDDFLDPLTFRRDSALGVPGLVEVYRQGRVAIANAIGAGVADDKAVYAYVPRMIEYYLGEQPLLDNVPTFLGWNPDHLAYMLDNAAELVIKAVGEAGGYGMLIGPAATREETEDFLKNVRANPRNYIAQPVIGLSRHPTFYPDARAFEPAHVDLRPYILVGQEVTIVPGGLTRVALRRGSLVVNSSQGGGSKDTWVLNHDGPAPARIQQQFQGATEPQEPHPAVPGEVKVEAQAGHTQVQSLGRMMQEQSLGGAQAHSRSPSLVQEEDPQSSTAGQHQWQGAAGEPLSAEERDEAGAPDSGVSDMLTSGQSGPGPADPKGDI
>NC_012527.1|WP_012694767.1|315046_315979_+|alpha-E-domain-containing-protein
MLSRLAESLYWIGRYMERAENTARLLTVNYYATLETSGQVSEEWGPLLDISGSKENFVRLHGRADGRTVPAWLAFDRNNPSSVSSSLAQARENARGLRDRIPSEMWECLNRAYYDLCFQNEEVLDRDGLFEFCSAARDTSQFFFGIAFATLPRDEGWLFMRAGQMLERGDNVLRLVQTRYRSHAADPAQLAVHNHRWIAVLKTASAYEAYRKCNHANVSPRTIAEFLLLNPGFPRSVRYSGENLHDALAGIDRIHPGAHPALLREAKWLVARLDHATIEELIARDQAELGTLLTDFNRIGSAISASYFTV
>NC_012527.1|WP_012694768.1|316006_316852_+|transglutaminase-family-protein
MRADIRHITEYRYAEPAWDSFNEVRLSPEVSARQDLRSFHLAVRPEPSLVSTHRDYFGSLIHHVHVHEPHQVLRIEAQALVITRPLPGLETVPFSALDELRGEVTEFLVSSPRVPSGRWPEVFGVRAPQPHEDLSAFMVALTTQLHRQFTYHPGATSVSTTLEQFARDLRGVCQDYTHAMLGICRTLGIPARYVSGYLYSGGEMIGADATHAWVEVLIPGQGWVGFDPTNDMLAGEKHIKIGHGRDYPDVSPVRGTYYGGGGEASLNVEVRVYGDPPARQE
>NC_012527.1|WP_012694769.1|316929_317370_-|response-regulator
MRSTPQSCCTLSPHILLIDDNPLDRELTELALLEVAPGSSLTLAESGIQAMQLLWAGLRTDLILLDVNMPGMHGFDVLQALRADTSLNHIPVVMLSTSGAERDRAQAQALEVDGYMVKASRFEAYVQQMLGLMRWYHAAAPLQTLA
>NC_012527.1|WP_012694770.1|317570_318206_+|LexA-family-transcriptional-regulator
MPPELTRTRRLILDAILRLQAEDTPATLGAVAQATGLTKQAVSYQTVLLREAHYLEPAASRYAPLILTSKARALIGGGGFPLVGEIAAGQPGHAEQNVEAYITRLDQVIDMKEGDYLLRVRGDSMIGVGIYPQDIVIVRPNETVPNGDIAVVLLPGESTATLKRVEHQNSKITLHSANPDYPPMTFPARDVRIQGCLVAHIGQAALRSRRV
>NC_012527.1|WP_012694771.1|318208_319480_+|Y-family-DNA-polymerase
MAGRTPSLIACVLLSPWPLELLQRRHPGVPVAVLSEEGSGGGRRVLHVSPGARDAGVKVGMRDTAALSRCPELHAETMNAPLAAAAWNELLEQMYVRYSDRVEGRTPGLIFLKLSLGAARDLAAALQAPVGLAGSLEVAHLAALRAKAGEVREVHPGEQAEQAFLNLVPLEHLQVLGLSPAQAERLRFLGVTGLADLCKWSAAQREAFLGVDMGTQVNRFLKGHRTEQLPRYVPGQILEASLDTDAPLLNSLEADAAFQELLPGLMTGLRGRTAAYLTVRCDTLGGSLTATRKLKWPLDSGGLMRVAGLALEDTGALAIGIDRLSVQFSGLQQPSRMVGLWAGLADLDVTRNVLDRFPDALVRVRWLDPWAYTTNAMYEWVDWQTGEVRPTPMTPQMTWTPTRAQAREKAVDRILAFFEGAQP

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Crispr_ID: NC_012527_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012527_2

306979-307233

Orphan

Consensus_repeat	Method
CTCCACGACACACCTGAGCGATT	CRISPRCasFinder

4 spacers

The CRISPR arrays of NC_012527_2

>merge|NC_012527|2|306979-307233|CRISPRCasFinder
CTCCACGACACACCTGAGCGATTACCATTCCAGACGACGACATACCTGAGCGATTCTCCACGACACACCTGAGCGAATGCCCTGGCTGCGTCGGCGACACACTTGAGTAATGTTGGAAAGCAGCAACGACATACCTGAGCGATCAATGGCGACATACCTGAGCGGTTCTATACGACACACCTGAGCGGTTCGCCAGCGGTCCTGCGACACACCTGAGCGATTTGTGCGTCAAGACGACGACATACTTGAGCGATT

>NC_012527|2|2|306979-307233|CRISPRCasFinder
CTCCACGACACACCTGAGCGATT	ACCATTCCAGACGACGACATACCTGAGCGATT
CTCCACGACACACCTGAGCGAAT	GCCCTGGCTGCGTCGGCGACACACTTGAGTAATGTTGGAAAGC
AGCAACGACATACCTGAGCGATC	AATGGCGACATACCTGAGCGGTT
CTATACGACACACCTGAGCGGTT	CGCCAGCGGTCCTGCGACACACCTGAGCGATTTGTGCGTCAA
GACGACGACATACTTGAGCGATT

Protein	Signature genes	Signature genes Name	Protein_function
NC_012527.1\|WP_012694762.1\|307376_308738_+\|plasmid-replication-initiator-protein	unknown	unknown	gnl\|CDD\|370826
NC_012527.1\|WP_162485672.1\|295719_296504_+\|IS5-like-element-ISDds9-family-transposase	unknown	unknown	gnl\|CDD\|379129
NC_012527.1\|WP_012694770.1\|317570_318206_+\|LexA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224885
NC_012527.1\|WP_012694754.1\|297106_297571_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_012527.1\|WP_012694763.1\|308972_310607_-\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213027
NC_012527.1\|WP_012694756.1\|298848_300375_+\|sensor-domain-containing-diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_012527.1\|WP_162485671.1\|294587_294839_-\|hypothetical-protein	unknown	unknown	unknown
NC_012527.1\|WP_012694767.1\|315046_315979_+\|alpha-E-domain-containing-protein	unknown	unknown	gnl\|CDD\|377234
NC_012527.1\|WP_162485673.1\|301667_302414_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NC_012527.1\|WP_012694761.1\|304611_305760_+\|diaminopropionate-ammonia-lyase	unknown	unknown	gnl\|CDD\|236186
NC_012527.1\|WP_012694760.1\|303456_304590_+\|ArgE/DapE-family-deacylase	unknown	unknown	gnl\|CDD\|349935
NC_012527.1\|WP_012694757.1\|300641_300974_-\|hypothetical-protein	unknown	unknown	unknown
NC_012527.1\|WP_012694771.1\|318208_319480_+\|Y-family-DNA-polymerase	unknown	unknown	gnl\|CDD\|176458
NC_012527.1\|WP_012694753.1\|296509_296881_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378504
NC_012527.1\|WP_012694766.1\|313244_315047_+\|circularly-permuted-type-2-ATP-grasp-protein	unknown	unknown	gnl\|CDD\|225190
NC_012527.1\|WP_012694768.1\|316006_316852_+\|transglutaminase-family-protein	unknown	unknown	gnl\|CDD\|224224
NC_012527.1\|WP_012694769.1\|316929_317370_-\|response-regulator	unknown	unknown	gnl\|CDD\|381108
NC_012527.1\|WP_012694755.1\|297941_298355_+\|hypothetical-protein	unknown	unknown	unknown
NC_012527.1\|WP_162485674.1\|311563_311857_-\|hypothetical-protein	unknown	unknown	unknown
NC_012527.1\|WP_162485690.1\|312053_312857_-\|transglutaminase-family-protein	unknown	unknown	gnl\|CDD\|224224

Protein	Function_ID	Function_description	E-value
NC_012527.1\|WP_012694762.1\|307376_308738_+\|plasmid-replication-initiator-protein	gnl\|CDD\|370826	pfam10134, RPA, Replication initiator protein A. Members of this family of bacterial proteins are single-stranded DNA binding proteins that are involved in DNA replication, repair and recombination.	1.38987e-16
NC_012527.1\|WP_162485672.1\|295719_296504_+\|IS5-like-element-ISDds9-family-transposase	gnl\|CDD\|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	2.92037e-26
NC_012527.1\|WP_012694754.1\|297106_297571_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.17427e-25
NC_012527.1\|WP_012694763.1\|308972_310607_-\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213027	cd10970, CE4_DAC_u1_6s, Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel. This family contains uncharacterized prokaryotic polysaccharide deacetylases. Although their biological functions remain unknown, all members of the family contain a conserved domain with a 6-stranded beta/alpha barrel, which is similar to the catalytic NodB homology domain of rhizobial NodB-like proteins, belonging to the larger carbohydrate esterase 4 (CE4) superfamily.	1.80734e-64
NC_012527.1\|WP_012694756.1\|298848_300375_+\|sensor-domain-containing-diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.67857e-37
NC_012527.1\|WP_012694767.1\|315046_315979_+\|alpha-E-domain-containing-protein	gnl\|CDD\|377234	pfam04168, Alpha-E, A predicted alpha-helical domain with a conserved ER motif. An uncharacterized alpha helical domain containing a highly conserved ER motif and typically found as a tandem duplication. Contextual analysis suggests that it functions in a distinct peptide synthesis/modification system comprising of a transglutaminase, a peptidase of the NTN-hydrolase superfamily, an active and inactive circularly permuted ATP-grasp domains and a transglutaminase fused N-terminal to a circularly permuted COOH-NH2 ligase domain.	1.47854e-103
NC_012527.1\|WP_162485673.1\|301667_302414_+\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	1.29015e-07
NC_012527.1\|WP_012694761.1\|304611_305760_+\|diaminopropionate-ammonia-lyase	gnl\|CDD\|236186	PRK08206, PRK08206, diaminopropionate ammonia-lyase; Provisional.	7.46181e-120
NC_012527.1\|WP_012694760.1\|303456_304590_+\|ArgE/DapE-family-deacylase	gnl\|CDD\|349935	cd08013, M20_ArgE_DapE-like, M20 peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases. Peptidase M20 family, uncharacterized protein subfamily with similarity to acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE) subfamily. This group includes the hypothetical protein ygeY from Escherichia coli, a putative deacetylase, but many in this subfamily are classified as unassigned peptidases. ArgE/DapE enzymes catalyze analogous reactions and share a common activator, the metal ion (usually Co2+ or Zn2+). ArgE catalyzes a broad range of substrates, including N-acetylornithine, alpha-N-acetylmethionine and alpha-N-formylmethionine, while DapE catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelate (L,L-SDAP) to L,L-diaminopimelate and succinate. Proteins in this subfamily are mostly fungal and bacterial, and have been inferred by homology as being related to both ArgE and DapE.	0
NC_012527.1\|WP_162485690.1\|312053_312857_-\|transglutaminase-family-protein	gnl\|CDD\|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	8.66526e-35
NC_012527.1\|WP_012694771.1\|318208_319480_+\|Y-family-DNA-polymerase	gnl\|CDD\|176458	cd03468, PolY_like, DNA Polymerase Y-family. Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.	1.77647e-11
NC_012527.1\|WP_012694753.1\|296509_296881_+\|hypothetical-protein	gnl\|CDD\|378504	pfam10882, bPH_5, Bacterial PH domain. This family of proteins with unknown function appear to be related to bacterial PH domains. This family was formerly known as DUF2679.	0.000577089
NC_012527.1\|WP_012694770.1\|317570_318206_+\|LexA-family-transcriptional-regulator	gnl\|CDD\|224885	COG1974, LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms].	2.67431e-35
NC_012527.1\|WP_012694768.1\|316006_316852_+\|transglutaminase-family-protein	gnl\|CDD\|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	1.11242e-52
NC_012527.1\|WP_012694769.1\|316929_317370_-\|response-regulator	gnl\|CDD\|381108	cd17557, REC_Rcp-like, phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains. This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	4.93292e-40
NC_012527.1\|WP_012694766.1\|313244_315047_+\|circularly-permuted-type-2-ATP-grasp-protein	gnl\|CDD\|225190	COG2308, COG2308, Uncharacterized conserved protein [Function unknown].	0

>NC_012527.1|WP_012694761.1|304611_305760_+|diaminopropionate-ammonia-lyase
MTTQTDQPRFYFNPAVQTFAAAVEPEVLEFHRKLPGYLPTPLVRAPRLAEALNVAEAWVKDEASRLGLPAYKILGASWATYRELDTRFGPFRPWQSLAELAAQLSPHRPLTLVAATDGNHGRAVARTARWLGLAAHILVPEDMVRARIQAIEEEGAQVQIVRGSYDDAVEASARLADAAHLVISDTAWDGYTRVPGWVIAGYSTIFQEIDAQLAQQGARPPHLVAAQMGVGSLAAAVVGHYRTPARQTQVAGVEPTRADCVLRSLEAGRPTEVPGPHTSMMAGLNCGNTSPLAWPLLQGGLSASMAIPDERAEQAMRLLAQDGVTSGESGAAGAGGLLELLAGSQAQASRRTLGITPQSTVLVISTEGATDPAAYARIVPTS
>NC_012527.1|WP_012694760.1|303456_304590_+|ArgE/DapE-family-deacylase
MTQSLQDLLAALVRINSINPSLVPGAAGEAELATFVAGWLQDHGIEAVIDEAAPGRLSVIGTVRGTGGGRSLLLNAHLDTVGTDHMPEAFNPVVRDGRMYGRGTYDMKGGLAACLFALLDAREAGLRGDVILAAVADEEHASLGMQSVLKTVRADAAIVTEPTSLQLCVAHKGFTWHEITTHGRAAHGSRPDLGTDAIAHMGRVLVRLEALQRELEERPPHPLLGHASVHASLITGGQELSSYPERCTLQIERRTLPGETRDEVEQEWTALLGELAQDPQFHAEHRITLLREPFGVSEEAPIVQVLHAQAAQVLGEAPQHIGQTFWMDAAFLAGAGIPTVVFGPHGTGAHATEEWVDLASVEQCRAVLSATVRAFCA
>NC_012527.1|WP_162485673.1|301667_302414_+|universal-stress-protein
MTSPGFSPLTYLVPLDGRVGPTWVTEQAIELASAHGGTVLGLSTLKGPEAQNDLHSFQERCRVTGIAARSLHLPGPRFQGIMEASKRADLVMVAWTAESARVLDFSTFGALVRHATCPVWIAPPSGRVPAELTVAFHGQRKAFHAIAQAAKLAQTWQLPVDTLVVAEGPDINDHDTLIARQELRARNVIERHSRYERGVTGEILAAATSPDQLLIMGGAGDGPFFGLTLSRIVRQVLRLPRGPVLICP
>NC_012527.1|WP_012694757.1|300641_300974_-|hypothetical-protein
MDLPAAKQVVQQIINDLSLPDGTRLGVDVDANPDRLNIIAISGRRAGVVVITKEALEDHGHKAINAAIERLRRAIYDKDLPLLTGAPVQLGMLDSRGWTDGSVSPYSNDS
>NC_012527.1|WP_012694756.1|298848_300375_+|sensor-domain-containing-diguanylate-cyclase
MPSAPLPEQEYARLLELARYNILDTAPEESFDRLTRLAARTLRVPGVILNFVDQGRQWRKSWFGDGETNCSREDSFCAWTILSDDVLAVSDAREDPRFHDYKLVVGDPNIRMYAGAPLVTPSGHRIGSLCVFSAEARELDLDDQATLRDLAALVMDELELRLHNHVLQSQINQQDQQLWELRQTVAHAQVLEDINGLTETATTPEEVTLAVAAKIGEAIHADWTGLIAFSGNDATIQVAHHQPDLSPALLAFASRLPQLPCGVTRGMRGVTHTAYIEDYRQHPDALQEGVDAGFKSAALVPLGQYGEIEFLLIAARAERGSRAAWRSSDRALLDAAGRTVRAALVRRAALEASLLAARQDRLTGIANRRAFDHDLELRMQAGQPFTFALMDLDGFKQVNDVEGHAQGDRVLQVFALALRDTVSSYGQVYRYGGDEFALLLDPLTDERALEHVDSAVLAARQVTTRFVGASVGIVQMGNEDNPYCPSELQQRADTRMYEVKRRRQAALN
>NC_012527.1|WP_012694755.1|297941_298355_+|hypothetical-protein
MRQQDSRTDDHQTQFANALKQLMVAHGLGSVRARGDSGFLGLTPAGKFETTDLAFKFMAPDEHLAAAQALGLPAPQIGPSGRSARPQDMERFVRATGQLFDEYGVMNLEFTREALLGFRKTGHTVDFVVEGITLTLR
>NC_012527.1|WP_012694754.1|297106_297571_+|MarR-family-transcriptional-regulator
MTQNLTKPALPKVTLDLEDQLCFDLYAAARLITSAHRPFLLPLNLTYPQYVVMLTLWQHGPQTVTELGEYLHLDSGTLSPLLKRLETTGYVTRSKSALDERATIIELTPAGAALKERVTDVPSAVACQVGLKPEEKQKMQEQLRAMIARLSGDR
>NC_012527.1|WP_012694753.1|296509_296881_+|hypothetical-protein
MESVAIGLILLTLPPLLYIVSQKTGVRYTWTPDALQVDTGLRRYIFPYATTTARLTTQPLGSRIWGTAVSGSVTGRYTLDSSTVQALATTARPAQALLLEAGQQTFYVTPERAEEFAARFLAK
>NC_012527.1|WP_162485672.1|295719_296504_+|IS5-like-element-ISDds9-family-transposase
MMRLTDQQWTVLAPLLPRPVKRTRRGRTRQPDREVLEGILWILRTGAQWDALPKGEYPSKTTCHDRFQEWNEQNVFPTVLSALYELGEEEHLLDLREAFIDGTFSPAKKGARTSGQPKKGKGTKVMIMVDASGVPLAVHTSSASPAEVTLVHDTLEASFGMDFPKRLIGDKAYDSDGLDVELETLGIEMIAPNRRNRKKTQDGRPLRRYRRRWKVERTIAWLQSFRRVRTRDEVKAQNFLGMVQLACIVILLRLVTSPPVP
>NC_012527.1|WP_162485671.1|294587_294839_-|hypothetical-protein
MEMLFTAVVVGIGLLDLLLYLFIPRRVPPPTCQLTLKHPPRKSVPASAWERKIVTSVHEVISEPRHPGIPSGRNIPAHPEVNF
>NC_012527.1|WP_012694762.1|307376_308738_+|plasmid-replication-initiator-protein
MTSPPSRFDELNLSRLNLISAVDQAEVSEWDVTFEAHGRIVHVRCEALPKYAVPHGLDSDVTAALINLYIELGEPEDGRFSVSATTLLKLCGWHNTGKYHGILRVCLERLHTSSYSVSGGWRDHPKGRWTHAKFHFIESLDFSSSDGAGAFDDRTIIAGRLADVIVASIRSGYVKPLDTEFMLSLSRPRTRALYRILDGARYDPDHPDVRLDTLEFNLIQWADQCKIPSTIPGNIRRALASPHEELIKRGYLRAATLSGRGKDQRVRYEFVREFVAMDAVLARRFRSYGVADGVARKLLVEHGRDALIASMDRFDGLVRQGVLVVKKTPAAALMHLINHPDDYPYPKGAPAAPAPVRPARVEPVMEAPSVEAEFASLSLEQAAERLISRMNVHYRKLLSVSDLDTLRQAVMKELLSPSAVLEEATAAVVKLQRENFAQTLRARLGLPEERPIK
>NC_012527.1|WP_012694763.1|308972_310607_-|polysaccharide-deacetylase-family-protein
MKPYLSPAALILTALLSACSTDSSTPTATEDTTAISELGTFDAAFTNPQGGTMRSLSASVALQPATPLGAVDIRVAGSGMYDDERSNRRYLWGVFEVTNTSKTNLSNLTMVAYTKAGASIGGTAITRLQDAQGRAYLNERVAQNIRPGDHLNILNSYAFQGLTEDEAQRIETGARTGKLIGTNDDVLEYGFTVINPRDGSQTLRPGETGTLVLATKLPLLAGNAPQKFNMSLLLTTGGARRVTRNVGESNESVHLRARLSGAREIAYIGPDTNTAPGRYRTVRIPNIRLTTGAKPTYLLDLEEKLSSCVQGLQPTGLRPLNNAGPMVTFITDDGAAADHSRLLPLFKQKGVVATAAIATQNIISGDPYFATPEQVRDLQRAGWEIASHTRTHPDLVTLSDAELSAEIEGSKRELEDLGFRADTFVYPYGSHNPTVREKVCQHYRTAFIDRGGANDTPLNTNYQLRRVAFGAWTDAGQNTMDAYKAAVDSAIARNSWLVFMLHPGNREQHNEQQQQYLADTIDYVRGKNVPIVTAGDALYRLGAK
>NC_012527.1|WP_162485674.1|311563_311857_-|hypothetical-protein
MKIRHDRDAGRGRVLSSECLTIDEGTTVRIVKHEASGGQLCHYELLDEETGLMYTAECGTGEGRYDDVYTYRVQEPGIRVGSQSMGQVMGTKTSGTR
>NC_012527.1|WP_162485690.1|312053_312857_-|transglutaminase-family-protein
MLFVVEPQNRPGQQIVQTREYLDPSAGVGRWSRYTDVFGNSIWRVLGVGHTLQVGQDVIVQVPAHSDPQHPDLPKTPVEDLPDEVLQFLLPSRYVDSDLISNEAWERFGHIQGGWAQVQAISHHLYSTCSYGAASTSSTTAQQAYQSGRAVCRDFAHMGVAFCRALNIPARYVCGYLGDIGVPSTDTPMDFHAWFEAWIDGAWRTFDARHNKPRTGRVLIATGRDAADVAFTTSFGAARLTRMQVWADQVDPGFTLPDTWAPPQPRA
>NC_012527.1|WP_012694766.1|313244_315047_+|circularly-permuted-type-2-ATP-grasp-protein
MEQYDQGTTFFDEMFTPQGQVRPHYQGVLSYFRRLGTTEFQRRQALMDLAFRNQGITFTVYGDSAGVERTFPFDPVPRIIPASEWSALEAGLKQRVKALNAFLRDVYSDGQILKDGIIPRELVYTSSNFRREVHGLQVPLGIYTHIVGSDLIRDEQGRYLVLEDNLRSPSGVSYLLANRQAMTRIFPGMFERQGVRTVDHYTTALLGVLSSLSPRAPEATVVVLTPGMYNSAYFEHAYLAQQMGVELVEGRDLFVDGGRVWMRTTSGRTQVDVIYRRIDDDFLDPLTFRRDSALGVPGLVEVYRQGRVAIANAIGAGVADDKAVYAYVPRMIEYYLGEQPLLDNVPTFLGWNPDHLAYMLDNAAELVIKAVGEAGGYGMLIGPAATREETEDFLKNVRANPRNYIAQPVIGLSRHPTFYPDARAFEPAHVDLRPYILVGQEVTIVPGGLTRVALRRGSLVVNSSQGGGSKDTWVLNHDGPAPARIQQQFQGATEPQEPHPAVPGEVKVEAQAGHTQVQSLGRMMQEQSLGGAQAHSRSPSLVQEEDPQSSTAGQHQWQGAAGEPLSAEERDEAGAPDSGVSDMLTSGQSGPGPADPKGDI
>NC_012527.1|WP_012694767.1|315046_315979_+|alpha-E-domain-containing-protein
MLSRLAESLYWIGRYMERAENTARLLTVNYYATLETSGQVSEEWGPLLDISGSKENFVRLHGRADGRTVPAWLAFDRNNPSSVSSSLAQARENARGLRDRIPSEMWECLNRAYYDLCFQNEEVLDRDGLFEFCSAARDTSQFFFGIAFATLPRDEGWLFMRAGQMLERGDNVLRLVQTRYRSHAADPAQLAVHNHRWIAVLKTASAYEAYRKCNHANVSPRTIAEFLLLNPGFPRSVRYSGENLHDALAGIDRIHPGAHPALLREAKWLVARLDHATIEELIARDQAELGTLLTDFNRIGSAISASYFTV
>NC_012527.1|WP_012694768.1|316006_316852_+|transglutaminase-family-protein
MRADIRHITEYRYAEPAWDSFNEVRLSPEVSARQDLRSFHLAVRPEPSLVSTHRDYFGSLIHHVHVHEPHQVLRIEAQALVITRPLPGLETVPFSALDELRGEVTEFLVSSPRVPSGRWPEVFGVRAPQPHEDLSAFMVALTTQLHRQFTYHPGATSVSTTLEQFARDLRGVCQDYTHAMLGICRTLGIPARYVSGYLYSGGEMIGADATHAWVEVLIPGQGWVGFDPTNDMLAGEKHIKIGHGRDYPDVSPVRGTYYGGGGEASLNVEVRVYGDPPARQE
>NC_012527.1|WP_012694769.1|316929_317370_-|response-regulator
MRSTPQSCCTLSPHILLIDDNPLDRELTELALLEVAPGSSLTLAESGIQAMQLLWAGLRTDLILLDVNMPGMHGFDVLQALRADTSLNHIPVVMLSTSGAERDRAQAQALEVDGYMVKASRFEAYVQQMLGLMRWYHAAAPLQTLA
>NC_012527.1|WP_012694770.1|317570_318206_+|LexA-family-transcriptional-regulator
MPPELTRTRRLILDAILRLQAEDTPATLGAVAQATGLTKQAVSYQTVLLREAHYLEPAASRYAPLILTSKARALIGGGGFPLVGEIAAGQPGHAEQNVEAYITRLDQVIDMKEGDYLLRVRGDSMIGVGIYPQDIVIVRPNETVPNGDIAVVLLPGESTATLKRVEHQNSKITLHSANPDYPPMTFPARDVRIQGCLVAHIGQAALRSRRV
>NC_012527.1|WP_012694771.1|318208_319480_+|Y-family-DNA-polymerase
MAGRTPSLIACVLLSPWPLELLQRRHPGVPVAVLSEEGSGGGRRVLHVSPGARDAGVKVGMRDTAALSRCPELHAETMNAPLAAAAWNELLEQMYVRYSDRVEGRTPGLIFLKLSLGAARDLAAALQAPVGLAGSLEVAHLAALRAKAGEVREVHPGEQAEQAFLNLVPLEHLQVLGLSPAQAERLRFLGVTGLADLCKWSAAQREAFLGVDMGTQVNRFLKGHRTEQLPRYVPGQILEASLDTDAPLLNSLEADAAFQELLPGLMTGLRGRTAAYLTVRCDTLGGSLTATRKLKWPLDSGGLMRVAGLALEDTGALAIGIDRLSVQFSGLQQPSRMVGLWAGLADLDVTRNVLDRFPDALVRVRWLDPWAYTTNAMYEWVDWQTGEVRPTPMTPQMTWTPTRAQAREKAVDRILAFFEGAQP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_012527_1	1.1\|306605\|40\|NC_012527\|CRISPRCasFinder	306605-306644	40	NC_012527	Deinococcus deserti VCD115 plasmid 1, complete sequence	306605-306644	0	1.0
NC_012527_1	1.2\|306668\|43\|NC_012527\|CRISPRCasFinder	306668-306710	43	NC_012527	Deinococcus deserti VCD115 plasmid 1, complete sequence	306668-306710	0	1.0
NC_012527_1	1.3\|306734\|44\|NC_012527\|CRISPRCasFinder	306734-306777	44	NC_012527	Deinococcus deserti VCD115 plasmid 1, complete sequence	306734-306777	0	1.0
NC_012527_2	2.1\|307002\|32\|NC_012527\|CRISPRCasFinder	307002-307033	32	NC_012527	Deinococcus deserti VCD115 plasmid 1, complete sequence	307002-307033	0	1.0
NC_012527_2	2.2\|307057\|43\|NC_012527\|CRISPRCasFinder	307057-307099	43	NC_012527	Deinococcus deserti VCD115 plasmid 1, complete sequence	307057-307099	0	1.0
NC_012527_2	2.3\|307123\|23\|NC_012527\|CRISPRCasFinder	307123-307145	23	NC_012527	Deinococcus deserti VCD115 plasmid 1, complete sequence	307123-307145	0	1.0
NC_012527_2	2.4\|307169\|42\|NC_012527\|CRISPRCasFinder	307169-307210	42	NC_012527	Deinococcus deserti VCD115 plasmid 1, complete sequence	307169-307210	0	1.0
NC_012527_2	2.1\|307002\|32\|NC_012527\|CRISPRCasFinder	307002-307033	32	NC_012527	Deinococcus deserti VCD115 plasmid 1, complete sequence	307202-307233	7	0.781

1. spacer 1.1|306605|40|NC_012527|CRISPRCasFinder matches to NC_012527 (Deinococcus deserti VCD115 plasmid 1, complete sequence) position: , mismatch: 0, identity: 1.0

tcttctcataggtcgctgtgaatccttcccaacatgactc	CRISPR spacer
tcttctcataggtcgctgtgaatccttcccaacatgactc	Protospacer
****************************************

2. spacer 1.2|306668|43|NC_012527|CRISPRCasFinder matches to NC_012527 (Deinococcus deserti VCD115 plasmid 1, complete sequence) position: , mismatch: 0, identity: 1.0

cagtgtaaagacaccctcctgatgaggtgagttctcggctttg	CRISPR spacer
cagtgtaaagacaccctcctgatgaggtgagttctcggctttg	Protospacer
*******************************************

3. spacer 1.3|306734|44|NC_012527|CRISPRCasFinder matches to NC_012527 (Deinococcus deserti VCD115 plasmid 1, complete sequence) position: , mismatch: 0, identity: 1.0

tgtacgaaacggttctgttggacggatacaaaccacacgggcat	CRISPR spacer
tgtacgaaacggttctgttggacggatacaaaccacacgggcat	Protospacer
********************************************

4. spacer 2.1|307002|32|NC_012527|CRISPRCasFinder matches to NC_012527 (Deinococcus deserti VCD115 plasmid 1, complete sequence) position: , mismatch: 0, identity: 1.0

accattccagacgacgacatacctgagcgatt	CRISPR spacer
accattccagacgacgacatacctgagcgatt	Protospacer
********************************

5. spacer 2.2|307057|43|NC_012527|CRISPRCasFinder matches to NC_012527 (Deinococcus deserti VCD115 plasmid 1, complete sequence) position: , mismatch: 0, identity: 1.0

gccctggctgcgtcggcgacacacttgagtaatgttggaaagc	CRISPR spacer
gccctggctgcgtcggcgacacacttgagtaatgttggaaagc	Protospacer
*******************************************

6. spacer 2.3|307123|23|NC_012527|CRISPRCasFinder matches to NC_012527 (Deinococcus deserti VCD115 plasmid 1, complete sequence) position: , mismatch: 0, identity: 1.0

aatggcgacatacctgagcggtt	CRISPR spacer
aatggcgacatacctgagcggtt	Protospacer
***********************

7. spacer 2.4|307169|42|NC_012527|CRISPRCasFinder matches to NC_012527 (Deinococcus deserti VCD115 plasmid 1, complete sequence) position: , mismatch: 0, identity: 1.0

cgccagcggtcctgcgacacacctgagcgatttgtgcgtcaa	CRISPR spacer
cgccagcggtcctgcgacacacctgagcgatttgtgcgtcaa	Protospacer
******************************************

8. spacer 2.1|307002|32|NC_012527|CRISPRCasFinder matches to NC_012527 (Deinococcus deserti VCD115 plasmid 1, complete sequence) position: , mismatch: 7, identity: 0.781

accattccagacgacgacatacctgagcgatt	CRISPR spacer
gtgcgtcaagacgacgacatacttgagcgatt	Protospacer
..   ** **************.*********

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_012526_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012526_1

2805977-2806083

Orphan

Consensus_repeat	Method
TTGTTTCACCGTCAAGTTTCCCGTGAAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012526_1

>merge|NC_012526|1|2805977-2806083|CRISPRCasFinder
TTGTTTCACCGTCAAGTTTCCCGTGAAACGAAAGAATCGTCAAGCGAAAGGTGCGCCAGCACACCCTGGCGCACCTATTTGTTTCACCGTCAGGTTTCCCGTGAAAC

>NC_012526|1|1|2805977-2806083|CRISPRCasFinder
TTGTTTCACCGTCAAGTTTCCCGTGAAAC	GAAAGAATCGTCAAGCGAAAGGTGCGCCAGCACACCCTGGCGCACCTAT
TTGTTTCACCGTCAGGTTTCCCGTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012526.1\|WP_012694492.1\|2799402_2800674_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|274963
NC_012526.1\|WP_012694509.1\|2818488_2818800_-\|hypothetical-protein	unknown	unknown	unknown
NC_012526.1\|WP_012694501.1\|2810666_2811785_+\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|223997
NC_012526.1\|WP_162485628.1\|2795899_2796727_-\|metalloenzyme-domain-protein	unknown	unknown	gnl\|CDD\|293734
NC_012526.1\|WP_012694495.1\|2803321_2804167_-\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|275105
NC_012526.1\|WP_012694502.1\|2811781_2812801_+\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NC_012526.1\|WP_041227654.1\|2817418_2818492_+\|DNA-protecting-protein-DprA	unknown	unknown	gnl\|CDD\|223829
NC_012526.1\|WP_012694498.1\|2805641_2805962_-\|hypothetical-protein	unknown	unknown	unknown
NC_012526.1\|WP_012694503.1\|2812829_2813063_+\|hypothetical-protein	unknown	unknown	unknown
NC_012526.1\|WP_012694500.1\|2807967_2809569_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|223594
NC_012526.1\|WP_012694506.1\|2815213_2815873_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_012526.1\|WP_012694504.1\|2813089_2814604_+\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NC_012526.1\|WP_162485473.1\|2796799_2797000_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319901
NC_012526.1\|WP_012694497.1\|2804910_2805645_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NC_012526.1\|WP_012694507.1\|2815984_2817361_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_012526.1\|WP_012694491.1\|2797282_2799277_-\|elongation-factor-G	unknown	unknown	gnl\|CDD\|237186
NC_012526.1\|WP_012694505.1\|2814783_2815197_+\|hypothetical-protein	unknown	unknown	unknown
NC_012526.1\|WP_041227289.1\|2800735_2801737_+\|YpdA-family-putative-bacillithiol-disulfide-reductase	unknown	unknown	gnl\|CDD\|188533
NC_012526.1\|WP_012694494.1\|2801888_2803250_+\|VanW-like-protein	unknown	unknown	gnl\|CDD\|225341
NC_012526.1\|WP_012694496.1\|2804150_2804900_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|224113

Protein	Function_ID	Function_description	E-value
NC_012526.1\|WP_012694492.1\|2799402_2800674_+\|AAA-family-ATPase	gnl\|CDD\|274963	TIGR04075, Ser/Thr_phosphatase_family_protein, polynucleotide kinase-phosphatase. Members of this protein family are the bacterial polynucleotide kinase-phosphatase (Pnkp) whose genes occur paired with genes for the 3' terminal RNA ribose 2'-O-methyltransferase Hen1. All members of the seed alignment belong to a cassette with the Hen1. The pair acts in bacterial RNA repair. This enzyme performs end-healing reactions on broken RNA, preparing from the RNA ligase to close the break. The working hypothesis is that the combination of Pnkp (RNA repair) and Hen1 (RNA modification) serves to first repair RNA damage from ribotoxins and then perform a modification that prevents the damage from recurring. [Transcription, RNA processing].	1.01875e-180
NC_012526.1\|WP_012694501.1\|2810666_2811785_+\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	gnl\|CDD\|223997	COG1071, AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion].	3.53198e-148
NC_012526.1\|WP_162485628.1\|2795899_2796727_-\|metalloenzyme-domain-protein	gnl\|CDD\|293734	cd16010, iPGM, 2 3 bisphosphoglycerate independent phosphoglycerate mutase iPGM. The 2,3-diphosphoglycerate- independent phosphoglycerate mutase (iPGM) catalyzes the interconversion of 3-phosphoglycerate (3PGA) and 2-phosphoglycerate (2PGA). They are the predominant PGM in plants and some other bacteria, including endospore forming Gram-positive bacteria and their close relatives. The two steps catalysis is a phosphatase reaction removing the phosphate from 2- or 3-phosphoglycerate, generating an enzyme-bound phosphoserine intermediate, followed by a phosphotransferase reaction as the phosphate is transferred from the enzyme back to the glycerate moiety. The iPGM exists as a dimer, each monomer binding 2 magnesium atoms, which are essential for enzymatic activity.	0.000646692
NC_012526.1\|WP_012694495.1\|2803321_2804167_-\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	1.1149e-79
NC_012526.1\|WP_012694502.1\|2811781_2812801_+\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	0
NC_012526.1\|WP_041227654.1\|2817418_2818492_+\|DNA-protecting-protein-DprA	gnl\|CDD\|223829	COG0758, Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion].	1.55277e-108
NC_012526.1\|WP_012694506.1\|2815213_2815873_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	9.08234e-69
NC_012526.1\|WP_012694504.1\|2813089_2814604_+\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	6.59521e-162
NC_012526.1\|WP_012694500.1\|2807967_2809569_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	3.03329e-90
NC_012526.1\|WP_012694507.1\|2815984_2817361_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.48992e-38
NC_012526.1\|WP_162485473.1\|2796799_2797000_-\|hypothetical-protein	gnl\|CDD\|319901	cd07235, MRD, Mitomycin C resistance protein (MRD). Mitomycin C (MC) is a naturally occurring antibiotic, and antitumor agent used in the treatment of cancer. Its antitumor activity is exerted primarily through monofunctional and bifunctional alkylation of DNA. MRD binds to MC and functions as a component of the MC exporting system. MC is bound to MRD by a stacking interaction between a His and a Trp. MRD adopts a structural fold similar to bleomycin resistance protein, glyoxalase I, and extradiol dioxygenases; and it has binding sites at an identical location to binding sites in these evolutionarily related enzymes.	1.13238e-13
NC_012526.1\|WP_012694497.1\|2804910_2805645_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	1.58685e-68
NC_012526.1\|WP_012694491.1\|2797282_2799277_-\|elongation-factor-G	gnl\|CDD\|237186	PRK12740, PRK12740, elongation factor G-like protein EF-G2.	0
NC_012526.1\|WP_041227289.1\|2800735_2801737_+\|YpdA-family-putative-bacillithiol-disulfide-reductase	gnl\|CDD\|188533	TIGR04018, thioredoxin_reductase, putative bacillithiol system oxidoreductase, YpdA family. Members of this protein family, including YpdA from Bacillus subtilis, are apparent oxidoreductases present only in species with an active bacillithiol system. They have been suggested actually to be thiol disulfide oxidoreductases (TDOR), although the evidence is incomplete. [Unknown function, Enzymes of unknown specificity].	4.05747e-172
NC_012526.1\|WP_012694494.1\|2801888_2803250_+\|VanW-like-protein	gnl\|CDD\|225341	COG2720, COG2720, Uncharacterized vancomycin resistance protein [Defense mechanisms].	1.68077e-103
NC_012526.1\|WP_012694496.1\|2804150_2804900_-\|ParA-family-protein	gnl\|CDD\|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	1.24955e-79

>NC_012526.1|WP_012694498.1|2805641_2805962_-|hypothetical-protein
MATFEQGLLLGVLIGEGHFGGDGKQPHVTVRMHTKHAGLFNTLLDLCPGSKLYGPYEHGGRSYYQWMVRGQVLREQLVPQLDALPLQSIDHHVYDRYMEMKQRYHL
>NC_012526.1|WP_012694497.1|2804910_2805645_-|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MNPEATELLLAGAQELGLDVAPVLDQFAALLVLLQEGNARFNLTALKTERDIVLKHFVDSLTCLGGGHLDGNHQVVDLGTGAGFPTLPLALMRAELQFTPVDSTRKKVEFVRATAEALGLQNVRPVAGRAETLTRQPEHRDRYDRVVVRAVAALPILAELALPFLRPGGLLVAQKGPISPEELRAGQRAAGELGGRVTEVEAFTLPVLGDARTLVVVEKLRDTPDRYPRREGVPNQQPLFWSAK
>NC_012526.1|WP_012694496.1|2804150_2804900_-|ParA-family-protein
MKVLGVVNQKGGVGKTTTAVNLAAYLAAGGRKVLLLDMDPQGNATSGLGLRGAEQGLYEALGEPARAAEFTLPTLQDGLFVLPSTPDLAGAGVELADDPDALTRLLASVGGYDLVLIDAPPSLGPLTVNVLAAVDALLIPLQAEYYALEGLAGLMETVERVQGGLNPRLKVLGVVLTMFDGRTNLAQEVETMVRGHFGELVFWSVVPRNVRLSEAPSFSKPINAFAPLSSGAAAYKRLADEVMQRVEKI
>NC_012526.1|WP_012694495.1|2803321_2804167_-|ParB/RepB/Spo0J-family-partition-protein
MSKKSSLGRGLDALLGAKAAPEAAGGPQVQTLSISRITQAAYQPRQVFAPEALAELAQSIRDKGVLQPLLVRPRGDNFEIVAGERRWRASQLAGLTEIPVIIRDLADREALEIAIVENLQREDLGPLEEARAYQALMNQGLNQEGVAQAVGKGRSTVANALRLLSLDSAALNALDRGQISAGHARAILAQPEKDRAWALDQIVTHGLNVREAEALKRETRAPGPIKVNPPRTYRQVELDLSRRTGTRVRITGEDKGRVELNYGSREELDRILSLLGYAADD
>NC_012526.1|WP_012694494.1|2801888_2803250_+|VanW-like-protein
MVSALSRALLLGTLLLGAHAAAQSVPVLPPAAPVTPVPPTEPAPVPVEPAPVDPAPVEPAPVEPPPAEPVPVDPAPRPPAKPVAPAQPAPQISAPLLINVEAQWPAVVNGKKTVVPFTRTLTIPGHRVSVLRQRGVITPSLEADVATFIKELPTEPQDARFEELWDGWTLVQRNGLKVDGAKTRQSILTALKNPKGVKATVVISGQVAPKRTLDYFVSRGITAHLGSGETNYHGSSPARMTNIHVGAASFKDRLFEGKTFSFNQMIGPISTQSGYVTGLVIAGERTASGVGGGICQVSTTVFRTLYKAGLPVVERRNHSYQVHYYDPQGMDATIYQPSQDLRFANDTGGALWFQADWNDKEARLSVHVFGKVRDHTVEVGAPRTLSTTPSPKDRLIQDATLNAGQRKQVDWAAPGAVIEVTRKFIRAGKVFKQDTLRSQYRPWPNIFLVGTKS
>NC_012526.1|WP_041227289.1|2800735_2801737_+|YpdA-family-putative-bacillithiol-disulfide-reductase
MSGLVDVAIIGAGPVGLAAAIACKRAGLSYVVLEKGCVVNAIFEYPTYMSFFTTAPELEIGNHPMVTGHDKPDRRDALMYYRLVTQREALNVEQYTEVTAVHAAPAGFTVQVEKRDGNSGVVEARRVVVATGYYDNPMALGIPGEDSDNVSHYYTEAHPFMGLNVTVIGAGNSAADAALDLWRGGANVTMVVRAPELKPTIKYWVRPDLENRIKEGSITAHFNSQVVEIHPDLVRVQRQDGTTWDLPTHFTFALTGYRPDLSFLSGLGLAQHPDECLVLSDHYESSVPGLFVAGSAGFAGKTNQVFIENGRFHADVAVAEITRQLGSGVLRQG
>NC_012526.1|WP_012694492.1|2799402_2800674_+|AAA-family-ATPase
MWQHDASMSGSPEQPRKVRLPALALVALIGARGAGKTTFAAEHLRPEEVVSAAQHGEDPLAPLLQAAGTRLSRGELAVVDAPLVRPHDRRRVVELARQHDVSAVAVVLDLPRPLLTQRLGPEGDRAALAAEVTELHRTLHGLEKEGFRRVWVLRSLQEVRQFSLQRVPLAPDRRDLEGPFDIIGDVHGCLPELLTLLDQLGYTRGQAMTPPPGRRAVFLGDLVDRGPDSAGVLRLVMDMVNSGAALCLPGNHEEKLLRALNGKAVRALHGLDVTLQQLHAAGEAFRSEVRAFVQSMPSHLLLDGGRLVVAHAGLPEHYHGRVSGRVRSFALYGDTDGRVDETGLPVRRDWARTYRGEALVVYGHTPVTAPRWLNGTVNIDTGCAFGGQLTALRYPELDTVSVPASEQYAVPGRPLLEAGIHPG
>NC_012526.1|WP_012694491.1|2797282_2799277_-|elongation-factor-G
MPVRIVSLAAHSGAGKTTLSEALLHRSGAISRAGRVEDGTTQSDHSEEERQHGFSIRTGVLRLQHRDTSITLLDTPGFADFVREIRGGIRAADNVIVVVSATGGVEVGTERVWTTADRFGMPRIVVLGKMDRERAHFAATLADVRATLPGPTVAAYLPDGEGPDFRGLVDVLSDEDQVPDELRSAVAEARTVLTDAIVESDDELMNRYLEGEEISTEELRAAFFRAVHAGQLYPALPVSATTGVGLDELLDLMVHGLRSAAERGDVTGVDGQTRAPTPEAPFSARVWRVSMDPYVGKVAHVRVWSGTLRAGDTVRNTTRGAELRPAHLYVASGRELQEVPELSAGMIGVLTKSPDLHTGDTLADPQHPIEYDPLELPDVVHTVALHPQTRQDEDRLGDALGKLLEEDPTLNYSREPQTGEMLLGGMGEMHTTIAVEKLAALGVKVSTTPPQIPYRETIRATAQAQGRHKKQSGGHGQFGDCVLRIQPGKGYLFSSAVVGGAIPSKYLPSIEKGVQDAMVKGSLAGFPVQDVHVTVLDGSYHEVDSSDLAFRMAGALAMRNALEQARPVLLEPVMLLRVRAPASFTGDLMSDLQTRRARVQGMEPEGSVFTISAVVPQSELQTYNADLRSMTGDRGAYSVKPFGYQEVPEHLARKVIEERRAAQV
>NC_012526.1|WP_162485473.1|2796799_2797000_-|hypothetical-protein
MLTFSGGRIGVVVQTDDAAEVDEVVRRVGDARYHVITEPFDAPWGQRCASGDPDGTHVDVLAWRPH
>NC_012526.1|WP_162485628.1|2795899_2796727_-|metalloenzyme-domain-protein
MGHPLDAPGGSAWEQALPTLRPLVDRGAALDATLGVPGQPQSGTGQSCWLTGQDAVRVMGEHFGPHPGPTLQRLLAQHSLPVQLVQAGARVALANHYAPAFFEAQRRRSRLGCFPFSIQAARLPLNPPGLPLVPASLGLDYRAPWLAHTMSLSDVSALGTALGGAARAWDLLILDLWFSDLLGHAGRDPTPVEVMRAARTYLCRVDALIEGLLSSGAEVVLSSDHGNMENLLIKAHTLARVPLAASWTDVRGPLHVVHGGQWLKTWMGLPGTAEF
>NC_012526.1|WP_012694500.1|2807967_2809569_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MDFASLRADLIGGDAAIRTPFGIRRVTYADYVASGRALHSVEDRIATLALPLYANTHTEDSATGAHSTHLTHQAQAYIKSQLGGDDTCKLLFCGSGSTAAVRRLQDILGLSVPCSHRETVLSNLPEHERPVVFVGPYEHHSNEVSWRETLAEVIEVPLCPRGGLDLDALRGLLRNPVYARRPKIGSFSAASNVTGLLTDTRTVARLLHANGAYAFFDFAASGPYVKIDMKPGAPDGYDAVFLSPHKFVGGPGTPGLLCFQQHLYQLQVPSTAGGGTVRYVSRQRHAYIEDIEAREDAGTPAILGKLRTALAFRVKEELGVKQLTQREHELFGRALAQLGANPRVQLLGNPDSARLAFLSFLVKTSQGTYLHPRLVVRLLNDLFGIQARGGCACAGPYGHALLNIDEEHSERYFQCIMGDLEGIKPGWTRLNLAPWATDEEVTFLLAAVEFIAEYGERFLPLYDFNWQTGAWTHADDQAPLDLFGHERPLKEEGAVPYQKYLSYAFQLASSLSERGEARAVPPQVPADLVFFAH
>NC_012526.1|WP_012694501.1|2810666_2811785_+|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha
MIQPFTAEPIQWVSESGVPVRDLPERFTPQLLRDLHALMLRAREFDRKLITLLRQGRTTFYAQSSGMEATQVGLARSIRVGHDWVWPYYRDHTLGLAMGVPMFELISQCLGSNSDPSRGRQMPHHFAAKRQNFVSISSSIASQVPPAAGNAMAQKYLGVDEITVCTFGDGATSEGDWHAGMNMAGAHQAPALFVCENNQWAISTHLRAQTASENIHIKAKAYGMPGFYVDGNDIVAVMEVCAHAAEWVRAGNGPALVECLTYRVGSHSNADADAEKHYRTREEVEEWLGRDPIVRIEKLLEHLGHPISAEERAQMIAQTHREVDEQVIQAEATGQPDWRIIFEDVYADMPGHLRDQEAQLRAEQEAGQEVRA
>NC_012526.1|WP_012694502.1|2811781_2812801_+|alpha-ketoacid-dehydrogenase-subunit-beta
MTATQQRNPASGGGETRTINLIQAVTEALHEELERDERVVLFGEDVGARGGVFMATAGLQATFGKHRVFDTPLSEASIVGAAVGMAVRGLRPVAEIQFADYMGPGFDQIISQAAKIRYRSGGQFTAPMVIRTPSGGGVKGGHHHSQSPEAYYTHTPGLKVVMPSTPYDAKGLLKAAIRGEDPVIYFEPKRLYRASKGEVPVHDFTVKLGEAAIRREGSDLSLIGYGGVMPDLEKAADALGAEGVSVEVIDLRSLVPWDKDRVLTSVQKTGRAVLVSEAPRIGNFMGEVAYTIQEQAFDYLTAPVGQVAGFDTPYPYVQDKVYLPGPNRIVRACVQALNY
>NC_012526.1|WP_012694503.1|2812829_2813063_+|hypothetical-protein
MKPELWRPLLGTLGLMIGFGLYGLIGKLAEPWQSVCIGALFVILGAVAYWYAQGERWIQVLGLLLAVYGVLRAFLLR
>NC_012526.1|WP_012694504.1|2813089_2814604_+|2-oxo-acid-dehydrogenase-subunit-E2
MKEVLLPELAESVVEGEILKWLVQEGDTIALEQPLCEVMTDKVTVELPSPVAGVLRQRLANEGDVVAVHAAIALIDETGGGASSSAPSAMQAIQDTAESPATADAQLPPQAQEEREQIGGSIVEASHLPKADDDSSSLFKAFASDEQVKVQGLGGRTPAPQGAAQPVRNDGRVLAVPAARQLARELGLDLNRIQGSGPNGRIRVSDVLAQTQGQTASSTAASSMPASAPAPQPASTAQAAAQPAPASSKAAQGGLPVAPVQYRTPKGYEHLEDRVPLRGMRRAISNQMVASHLYTVRTLTVDEVNLTRLVEFRNRVKDEAKAADVKLSYLPFIFKAVAVALRKYPSLNTSFDEATQEIVQKRYYNMGMAVATDAGLTVPVLKDVGRKSVFELAREVVDLAGRAQAGKLQPDELAGSTFSITNIGSIGALFSFPIINVPDAAILGVHSIVKRPIVDEDDNIVVAHMMYLSLSFDHRLVDGAEAARFCKEVIRLLENPDRLMLEAM
>NC_012526.1|WP_012694505.1|2814783_2815197_+|hypothetical-protein
MPRLLTLLLLLLLASPAGALQLIVWDRDFQTKVGYGESSGGKFNIQLLPRYSGPVVVLFSQTDEERRRATFPTLLSRYDGFLRGGQLTIEPPGNDDVTLAKFLAIFRLSVNVQSTGQTLTLPGLKVAGPDNIKINNK
>NC_012526.1|WP_012694506.1|2815213_2815873_+|response-regulator-transcription-factor
MLAQILVVEDDPHLGPLLKEYLSADYQVHHSATLRDAQAWLGTHSAQLILLDLNLPDGDGLDLVQALRQYSSTPVLVLSARSGVQERVAGLNAGADDYLTKPFAMPELDARITALLRRTAAGTGVNLGNTSLSTSSLLLTVDEKNINLTEHEARILELMMRTPERVFSRADIESHLYGWETPNSNSVEVRISQLRKKLEQAASDLRIRTIRNVGYVLQT
>NC_012526.1|WP_012694507.1|2815984_2817361_+|HAMP-domain-containing-histidine-kinase
MTRHVALSTARVAWRHSLRFRLALVYSLVALAITTLSGLVVITLLLGSMDRQFDARLNERADVLADQFTNLSKGLGQRPPAITGFTVLVDAQNRVALSSNGLNLAPGEPFPQLNEYRLPVQGTRVRAVTRKAGGFGTLWVGLPEDDLIAARESAMRALLLSALITPALMLLLGWWVGRRALAGLGQAADLADRIDPTRSLATLPLPQREDEVHRLLAAINRLLVRIEAGQAREKQLLGQIVHELGAPLTVLKASLNRAAERTGDVEVGRAALVADELTFTTQDLMQLARGQLEMKMVWHYIPARTLLGRLDRLVPGTRFEGDWSGGILCDPDRLTQALRNLLANARRAAGPDGTVSLTLEDTPEQVRFVVQDSGPGLPPELGERIFEPFISGSGSSGLGLSVSRQIAVMHGGNLTGSNQGGGAQFVLSLPSATLGDDQDDDLEETESAEVSTPAAAHR
>NC_012526.1|WP_041227654.1|2817418_2818492_+|DNA-protecting-protein-DprA
MPEPGKAELLALLTLRFTPHLGPRRIESLRRHFGTACEALSAPFSALREVPGLDSRSIAALGNAKARAQAEAELHLAQQLGVTLLGRGLSGYPQALEALGDPSPVLWVRGSLPELPVVPRSIGIVGTRAASPHALSMARMLAAELAHADVTVVSGLARGVDTAAHAAAVEAGGQSIGVLGSAVNRIYPPENEALSEQLTLVSEYPLGTGPAQHHFPTRNRLIAALSAGTLVVEGEFKSGSLITATHALECGRTVFAMPGRAGDPRAAGPHQLLRDGAVLTETARDILQEFGWGNAPARPLPTLPPDQAAVLEALTAPATLDDLRAATGLCLPELQTALVMLQLQGLAEESGGRWVRR
>NC_012526.1|WP_012694509.1|2818488_2818800_-|hypothetical-protein
MKVRFTARGVRVRIDDLELAALQRGEAQTTGVDWDGGGWSLTLDPQSDSVTGRGPLLEVGLRLLLPDLLDPSREGVTLSGPVRVDVEKDFGPQHIDAHESALS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

256930 : 263409

Staphylococcus_phage(50.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012692155.1\|256930_257401_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	6.6e-29	43.0
WP_012692156.1\|257452_258673_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	5.4e-99	47.1
WP_012692157.1\|258669_259329_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	4.9e-30	38.9
WP_012692158.1\|259328_260435_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	2.0e-39	34.6
WP_012692160.1\|260903_261866_-	hypothetical protein	NA	NA	NA	NA
WP_012692161.1\|262133_262868_-	NAD-dependent deacylase	S5M4R0	Bacillus_phage	1.2e-16	30.3
WP_012692162.1\|262893_263409_-	RNA 2'-phosphotransferase	A0A2H4UTN1	Bodo_saltans_virus	6.3e-33	42.4

DBSCAN-SWA_2

756756 : 843518

Tupanvirus(16.67%)

tail,plate,tRNA,integrase,transposase

attL 761158:761217|attR 795732:795824

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012692609.1\|756756_758706_+\|tRNA	threonine--tRNA ligase	A0A2K9L297	Tupanvirus	6.8e-120	36.3
WP_012692610.1\|758835_759846_-	DsbA family protein	NA	NA	NA	NA
WP_012692611.1\|759973_760687_+	triacylglycerol lipase	NA	NA	NA	NA
761158:761217	attL	NA	NA	NA	NA
WP_012692612.1\|761308_762496_-\|integrase	site-specific integrase	A0A2H4YHQ5	Gordonia_phage	1.5e-13	23.7
WP_012692613.1\|762580_762841_-	hypothetical protein	NA	NA	NA	NA
WP_049760435.1\|763018_765532_-	bifunctional DNA primase/polymerase	A0A2H4JF22	uncultured_Caudovirales_phage	1.1e-50	34.8
WP_083764271.1\|765528_765717_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_041227044.1\|765827_766994_+	hypothetical protein	NA	NA	NA	NA
WP_162485392.1\|767403_767955_+	hypothetical protein	NA	NA	NA	NA
WP_012692618.1\|767981_770732_-	DEAD/DEAH box helicase family protein	A0A2H4J643	uncultured_Caudovirales_phage	1.4e-22	22.2
WP_041227391.1\|770731_773497_-	DUF1156 domain-containing protein	NA	NA	NA	NA
WP_012692620.1\|773516_776300_-	DUF1156 domain-containing protein	NA	NA	NA	NA
WP_012692621.1\|776296_776917_-	DUF3780 domain-containing protein	NA	NA	NA	NA
WP_012692622.1\|776942_780017_-	DUF499 domain-containing protein	NA	NA	NA	NA
WP_162485393.1\|780409_785560_+	RecQ family ATP-dependent DNA helicase	F2NZ48	Diadromus_pulchellus_ascovirus	6.1e-51	36.4
WP_012692624.1\|785556_787737_+	hypothetical protein	NA	NA	NA	NA
WP_012692625.1\|787773_790323_-	ATP-dependent helicase	S5M596	Bacillus_phage	1.7e-46	25.6
WP_083764220.1\|790473_794319_+	SIR2 family protein	NA	NA	NA	NA
WP_012692627.1\|794452_795454_+\|transposase	IS4-like element ISDds2 family transposase	NA	NA	NA	NA
WP_012692629.1\|797240_798344_+	hypothetical protein	NA	NA	NA	NA
795732:795824	attR	NA	NA	NA	NA
WP_162485394.1\|798451_799861_+	hypothetical protein	NA	NA	NA	NA
WP_012692632.1\|801438_802125_-	type II secretion system protein	NA	NA	NA	NA
WP_012692633.1\|802121_802487_-	type II secretion system protein	NA	NA	NA	NA
WP_012692634.1\|802483_802900_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_162485395.1\|802896_804813_-	hypothetical protein	NA	NA	NA	NA
WP_083764222.1\|805733_808118_-	PAS domain S-box protein	A0A1V0SGX0	Hokovirus	2.8e-06	22.6
WP_012692637.1\|808953_809598_+	pyridoxamine 5'-phosphate oxidase	NA	NA	NA	NA
WP_041227394.1\|809688_811194_-	2-phosphoglycerate kinase	NA	NA	NA	NA
WP_012692639.1\|811321_811939_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_012692640.1\|812024_812882_+	ROK family protein	NA	NA	NA	NA
WP_012692641.1\|812931_813666_+	sporulation protein	NA	NA	NA	NA
WP_041227396.1\|813727_814909_+	amidohydrolase family protein	NA	NA	NA	NA
WP_012692643.1\|814912_815521_-	thymidine kinase	Q6GYZ9	Mycoplasma_phage	1.6e-22	37.3
WP_012692645.1\|815658_815877_-	50S ribosomal protein L31	NA	NA	NA	NA
WP_012692646.1\|815971_816964_-	ADP-ribosylglycohydrolase	A0A2K9L8G6	Tupanvirus	2.8e-05	23.6
WP_012692647.1\|817030_817552_+	DUF4388 domain-containing protein	NA	NA	NA	NA
WP_012692649.1\|818971_819466_+	NUDIX domain-containing protein	NA	NA	NA	NA
WP_012692650.1\|819462_822225_+\|tRNA	valine--tRNA ligase	A0A1V0SK04	Klosneuvirus	3.9e-137	36.8
WP_012692651.1\|822283_822886_-	HD domain-containing protein	NA	NA	NA	NA
WP_162485396.1\|823036_823351_-	hypothetical protein	NA	NA	NA	NA
WP_012692652.1\|823477_824611_-	cysteine desulfurase	H7BUW1	unidentified_phage	1.1e-32	39.1
WP_012692653.1\|824645_826313_-	PASTA domain-containing protein	NA	NA	NA	NA
WP_012692654.1\|826376_826673_-	hypothetical protein	NA	NA	NA	NA
WP_041227398.1\|826669_827386_-	AzlC family ABC transporter permease	NA	NA	NA	NA
WP_041227056.1\|827719_828175_+	alkyl hydroperoxide reductase	NA	NA	NA	NA
WP_012692657.1\|828304_828925_+	histidine phosphatase family protein	NA	NA	NA	NA
WP_012692658.1\|829130_830270_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_012692659.1\|830961_831249_-	type VI secretion protein	NA	NA	NA	NA
WP_049760436.1\|831281_831992_-	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_012692661.1\|836509_837052_-\|tail	phage tail protein	NA	NA	NA	NA
WP_012692662.1\|837232_837652_-	hypothetical protein	NA	NA	NA	NA
WP_041227402.1\|837663_838086_-\|tail	phage tail protein	NA	NA	NA	NA
WP_012692664.1\|838163_839813_-\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	1.6e-61	31.5
WP_012692665.1\|840040_840865_+	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_162485517.1\|841011_841332_+	GPW/gp25 family protein	NA	NA	NA	NA
WP_012692667.1\|841391_843518_+\|plate	putative baseplate assembly protein	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_012527

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_012526

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection