CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_011295	Coprothermobacter proteolyticus DSM 5265, complete sequence	4 crisprs	cas3,cas3HD,csa3,cas2,cas1	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_011295_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011295_1

41136-41230

Orphan

Consensus_repeat	Method
TCGTTTTTATCGTTCCTATAAGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_011295_1

>merge|NC_011295|1|41136-41230|CRISPRCasFinder
TCGTTTTTATCGTTCCTATAAGGAAGGAAAACAGCTTCTGATATTTGCAGAGTGCAATAAACATCATAGTTTAGTTTTTATCGTTCCTATAAGGA

>NC_011295|1|1|41136-41230|CRISPRCasFinder
TCGTTTTTATCGTTCCTATAAGGA	AGGAAAACAGCTTCTGATATTTGCAGAGTGCAATAAACATCATAGTT
TAGTTTTTATCGTTCCTATAAGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_011295.1\|WP_012544192.1\|48526_49396_+\|cysteine-synthase-family-protein	unknown	unknown	gnl\|CDD\|107204
NC_011295.1\|WP_143708061.1\|35776_35920_-\|DUF2620-family-protein	unknown	unknown	gnl\|CDD\|378513
NC_011295.1\|WP_143708141.1\|41699_42797_+\|DNA-recombination-protein-RmuC	unknown	unknown	gnl\|CDD\|224241
NC_011295.1\|WP_012544876.1\|44217_45033_+\|TIGR02391-family-protein	unknown	unknown	gnl\|CDD\|378194
NC_011295.1\|WP_143708062.1\|41233_41584_+\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_012544064.1\|42799_42937_+\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_041735491.1\|35944_36325_+\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_012543985.1\|37764_38361_+\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_041735494.1\|39256_39604_+\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_143708142.1\|43236_44091_+\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NC_011295.1\|WP_083760203.1\|36536_36713_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225080
NC_011295.1\|WP_012544402.1\|46921_47743_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381297
NC_011295.1\|WP_041735898.1\|45842_46712_+\|DUF1028-domain-containing-protein	unknown	unknown	gnl\|CDD\|377639
NC_011295.1\|WP_012543837.1\|47960_48530_+\|serine-acetyltransferase	unknown	unknown	gnl\|CDD\|223975
NC_011295.1\|WP_041735493.1\|38361_38949_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372757
NC_011295.1\|WP_012544727.1\|36884_37751_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|234698
NC_011295.1\|WP_012543836.1\|36325_36595_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377924
NC_011295.1\|WP_012543591.1\|49710_50361_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|237297
NC_011295.1\|WP_012543622.1\|39588_40935_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133045
NC_011295.1\|WP_012544661.1\|39042_39192_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378383

Protein	Function_ID	Function_description	E-value
NC_011295.1\|WP_012544192.1\|48526_49396_+\|cysteine-synthase-family-protein	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	4.73948e-122
NC_011295.1\|WP_143708061.1\|35776_35920_-\|DUF2620-family-protein	gnl\|CDD\|378513	pfam10941, DUF2620, Protein of unknown function DUF2620. This is a bacterial family of proteins with unknown function.	9.47514e-15
NC_011295.1\|WP_143708141.1\|41699_42797_+\|DNA-recombination-protein-RmuC	gnl\|CDD\|224241	COG1322, COG1322, Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only].	7.47689e-89
NC_011295.1\|WP_012544876.1\|44217_45033_+\|TIGR02391-family-protein	gnl\|CDD\|378194	pfam09509, Hypoth_Ymh, Protein of unknown function (Hypoth_ymh). This entry consists of a relatively rare prokaryotic protein family (about 8 occurrences per 200 genomes). Genes for members of this family appear to be associated variously with phage and plasmid regions, restriction system loci, transposons, and housekeeping genes. Their function is unknown.	1.44634e-52
NC_011295.1\|WP_012543591.1\|49710_50361_+\|peroxiredoxin	gnl\|CDD\|237297	PRK13189, PRK13189, peroxiredoxin; Provisional.	1.64265e-145
NC_011295.1\|WP_041735898.1\|45842_46712_+\|DUF1028-domain-containing-protein	gnl\|CDD\|377639	pfam06267, DUF1028, Family of unknown function (DUF1028). Family of bacterial and archaeal proteins with unknown function. Some members are associated with a C-terminal peptidoglycan binding domain. So perhaps this could be an enzyme involved in peptidoglycan metabolism.	7.22028e-109
NC_011295.1\|WP_143708142.1\|43236_44091_+\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	3.48521e-31
NC_011295.1\|WP_083760203.1\|36536_36713_+\|hypothetical-protein	gnl\|CDD\|225080	COG2169, Ada, Adenosine deaminase [Nucleotide transport and metabolism].	8.24483e-09
NC_011295.1\|WP_012544402.1\|46921_47743_+\|aldo/keto-reductase	gnl\|CDD\|381297	cd19071, AKR_AKR1-5-like, AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.	8.22973e-135
NC_011295.1\|WP_012543837.1\|47960_48530_+\|serine-acetyltransferase	gnl\|CDD\|223975	COG1045, CysE, Serine acetyltransferase [Amino acid transport and metabolism].	1.22425e-60
NC_011295.1\|WP_041735493.1\|38361_38949_+\|hypothetical-protein	gnl\|CDD\|372757	pfam13851, GAS, Growth-arrest specific micro-tubule binding. This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.	0.00104606
NC_011295.1\|WP_012544727.1\|36884_37751_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	3.33636e-76
NC_011295.1\|WP_012543836.1\|36325_36595_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	5.5746e-13
NC_011295.1\|WP_012543622.1\|39588_40935_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133045	cd06423, CESA_like, CESA_like is the cellulose synthase superfamily. The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.	1.54614e-53
NC_011295.1\|WP_012544661.1\|39042_39192_+\|hypothetical-protein	gnl\|CDD\|378383	pfam10087, DUF2325, Uncharacterized protein conserved in bacteria (DUF2325). Members of this family of hypothetical bacterial proteins have no known function.	9.97147e-05

>NC_011295.1|WP_012543622.1|39588_40935_+|glycosyltransferase-family-2-protein
METRLNTETKLPPSYKTVYIPVIYKFFIAQSIAFTWMIFSIRISIPWLKDLSSVVGLPLAVFIIAFIAYIPGYLVAFVAVSLLLDRQPPFKEKNPDLHVTILIAARNEAAKIRNTLKYIANQDYNGKIDVIIVDNNSTDGTLEAAQKAANEYGLNCTFLFEPKAGKSYALNTGLKAIKTEYFMTLDADTLLHKKAVNNIVARILSSPSDVCAVAGHVLARNSRDNILTRMQEWDYFLGIASLKRMQGLYQGTLVAQGAFSLYKTDVVREVGGWDDVIGEDIVLTWKFFEKGYRVFFEPLAIAFTEVPNRFKHFTRQRSRWTRGMLEGLKKAGPWKQERFLAIFLLGIDILIPLIDLAFTIFWIPGLVLAFFGKYYIVGPYTLLVLPLNVLVTVIMYSFQKNIFDALGLRVRRNRIGYTFYLLFYQIIHSPISVMGYIQEIFKLERVWK
>NC_011295.1|WP_041735494.1|39256_39604_+|hypothetical-protein
MCGVEVDDNLLSEKPCSIPTAHYVVFDELPEYADVYWVISVSNFRAALLAGKQVPGGMRYVSVSVKDDCLVEQLEDILLTSVEASGGARNISGFYGISDKLANLLLREASPWKQD
>NC_011295.1|WP_012544661.1|39042_39192_+|hypothetical-protein
MLTRLCSHEVMWAAKEYVADTGKPIAFSRASGVEGIVREVYKLLTEKEE
>NC_011295.1|WP_041735493.1|38361_38949_+|hypothetical-protein
MPIDTWPIEEYVRVYGRERITWLLLNLPLPEELERYRTEKLAAVIPKKSSGPQAVLWERIKQLGDELTRQRRRAENLAKQLFEEHAEKARLSEELHVLRKEIEQLKNNSQSATRNIDDVLRIKRLKTLISELREENTKLRRQLEELGIKEVQDIEGEYEERNDEAVEAVGKTQDIEEDVLGRIRNKNVAVYGRVG
>NC_011295.1|WP_012543985.1|37764_38361_+|hypothetical-protein
MLHLQLYFERFCRKCKKRIAVLVHDYGTINSIDEADQKLGNLNIPVMPIRCPQCGGEDWPEYALAHDATRNVTFQRIAIGTEDLPIVGGSVPYAHVRSPEEQAELERGLAKLKDFFSEREGKFWDEYCRWAVERWNEALKWLADIEWRKAYKELGIGIGANSGPAAYRKDAEKRFITQEEKERFWRTANSHLVYFELL
>NC_011295.1|WP_012544727.1|36884_37751_+|tyrosine-type-recombinase/integrase
MLELYHEYLVKKGKSPHTIKNYISDLMQFQKWFEESTGEQFSPGKITEIDVRSYRSYLINIRQLKPSSIKRKLEAIRKFLDWTVKQDIISKNPAKEVEAPASVTLPPRSLSEKEFLRLRRSFYKEGNERDIAIFEVLANTGIRVSELCSLKLSDVQISERKGKLIVRYGKGQKYREVPLNSDARKALNEYLKSRADENNERLFLGERGPLTPSGVFRIIKRYARDAGVEVSPHQLRHTFARRLLQSGADIVTVQQILGHANLNTTAVYLKPDYAEQEEAVEKISKLHL
>NC_011295.1|WP_083760203.1|36536_36713_+|hypothetical-protein
MVIQKPLQPKKYVGSIESNKYHLPTCRVEQIKPENRIWFDSEEEAQKAGYEPCKVCNP
>NC_011295.1|WP_012543836.1|36325_36595_+|copper-amine-oxidase-N-terminal-domain-containing-protein
MRDRASKYAITAIVIFFFLLSLQLPVLAAAPKIIIDGTELKIDANPVVVDGRTLVPLRGIFEALGAIISWDGNTKTITAQKICGEHRKQ
>NC_011295.1|WP_041735491.1|35944_36325_+|hypothetical-protein
MKNMLVIKQNLIPASPGEPLPYNTGFGLTERLYELLLKASKDMRTTMSEVIRMALNYVIFDEKQIKQLREKKEENDKLACWRTVNLNELQAKKITELSTKYGISKSKIINMSIGIFLKQIYNRDAL
>NC_011295.1|WP_143708061.1|35776_35920_-|DUF2620-family-protein
MAGRPPKEEEVVNAVKQGKVAFGFTNDHIDRAVPMIVNAILKEKGEV
>NC_011295.1|WP_143708062.1|41233_41584_+|hypothetical-protein
MKKNFSVIWGKFTIRKEKLTKGKHAILAIVWIYIETPLCYESGYFFSEHINFLSRKTLFAIELRKYEITIGGTEIAGYVFIAIYFSCDYCTFANCYICGGNEAQRRSGTNKIPNGA
>NC_011295.1|WP_143708141.1|41699_42797_+|DNA-recombination-protein-RmuC
MNSTITKNISEMGISQQNLIKNFSDTVSSLADKTEERLNRMRDTIEAKLKEIQDENSSKLEQMRQTVDEKLQSTLNARISESFKLVSERLEQVHSGLGEVQSLVNDVGDLKKVLSNIKTRGILGEDQLEAIIEDILVPGQYEKNVIVRPGSREVVEFAVKIPVENGGNGSYMWLPIDAKFPMEDFERLIDAEERCDTAECERLRKELENRLKQCAKDIRDKYIDPPNTTDFAIMFLPAESLFAEALRKPGFIEVLQRECRVLITGPTTLSAVLNSLRQGFKIFAIEKKAEEVWKLLGAVKTEVGKFGDLLEKVNKKLQEAQNVIEDASRKTRTIDRKLRNVEEISPEETAELLALSPSSPDDDAF
>NC_011295.1|WP_012544064.1|42799_42937_+|hypothetical-protein
MKKEIIKHLKLLILLNAFDGIVTHIGVSAGYIEEWNSKTPRKWAQ
>NC_011295.1|WP_143708142.1|43236_44091_+|thermonuclease-family-protein
MLILIAGLLAACGNEAAPTPPAAGKTAEAASNAQHVEAVSSSGSKQPKQEQQPTVEKPAAGDKIEQVTSTENEKAEEGIELIKAKVTKAVDGDTVYVKLESDKEEKVRFIGVDTPESTTKVEPYGKEATAYTKSKLLNKDVWLELDVQERDKYGRLLAYVWLSPPTKESDEEIRTKMFNAVLLLEGYAQVMTVPPNVKYAEYFRKYQQEAMEKSAGLWGLEVKEEKPAFSQAVSASYIGNKNSKKFHLPDCQWTEKIAPGNRVYFKSRDEAIKAGYEPCKVCKP
>NC_011295.1|WP_012544876.1|44217_45033_+|TIGR02391-family-protein
MGTSDENKTLKLFSLSALEKLADIVADYHTGSGITELFRKAGFPEIRHDGSTKRWFVYQALQQVHQQHYGPYNVLKVIEALCNPEEFIGKPQVQQQVLEKVNEILRFYDLFVGEDGKVRRTSETETALTTRLLEGRRFDERGFHPEIRKHARQLFLEGYYFHAVLECCKALEKFVREKSGINKHGAELMSAALNLNNGPLKLNSQRTESERNEQEGVMHLCIGLMRAIRNPASHEPALDWTITREDALDLLSLISYLFRQIEQAVYFRIRN
>NC_011295.1|WP_041735898.1|45842_46712_+|DUF1028-domain-containing-protein
MRNISTFSIVARDPKTGELGIAVQSKFLAVGAVVPWAKAGVGAIATQAAANLDYGELGLKLLKKGYSPQAVLDALLALDDGREDRQVGIVDANGNSVTYTGENCFPWAGGIAGQDFACQGNILVSEATVNALKETFLSTEGPLAKRLVTALDAAQDAGGDRRGRQSAALLVVKEKGSYGGYNDRYIDLRVDDHPDPIKELIRLLDLYNMYFSKTTEGEKVKVTPEIVSSMQEALRNLGYYDGPVSGAFDEKTKNAYKNFCEFENFEERLCEGNFVDKRVIEFLLNKGKA
>NC_011295.1|WP_012544402.1|46921_47743_+|aldo/keto-reductase
MSVLTETYVLHNGVKIPKIGFGTWQIPNGEVAYNSVSYALEVGYRHVDTAYVYGNEESVGKAIRESGIPRDQIFVTSKLPADVKTYDGTLDYFERTLRNLNMDYLDLYLIHWPWPWNEKGKDYKKENIEVWHAMEELYKSGRIRAIGVSNFDVEYLQVLMDNCSVKPMVNQIRFFIGNTQEEITQFCQQNGILVEAYSPLATGRLIENDTIKKIADKYNKTVAQICIRYVIQRNALPLPKSTTPSRIKENADVDFEISPEDMEYLNSLKDTVE
>NC_011295.1|WP_012543837.1|47960_48530_+|serine-acetyltransferase
MRLYILGTELKKARNALKEDRQALLKSDPSIETPADIRFHAGYRSLRLYRYAHAFYVAGFRNVSAFIHFISRVLYAVDIHPAAEIEPGVVVDHGMGVVIGSTAKVGSGTVIYHGVTLGAKNITTGKRHPQVGKNVFIGAGATLLGAINVGDGARIGAGSVVVEDVPPYSTVVGVPAKVVKQDCVKEVVA
>NC_011295.1|WP_012544192.1|48526_49396_+|cysteine-synthase-family-protein
MIGIMETPLVCIEPYGIYAKLERFNPTGSIKDRPAYFMLVHALKENLIQPGGTLVEPTSGNTGISLAALGSQVGIKVILTMPASVTPERVKLAQSYGAEVILTPAEKGIPGAIEKAKQLQEKHHAYIPDQFNNPFNVLAHELTTGPEILKQTNWEVDAFVAGVGSGGTISGVGRALRRVLGNRVKIIAVEPAESPVLSGGKGGSHIIQGIGAGFIPTIFDKDLVDEIITVRGNEALEGVKMLSAKGYSVGISSGANFIAALRIKEKYNLAHVVTVFPDDGLKYLSTIAY
>NC_011295.1|WP_012543591.1|49710_50361_+|peroxiredoxin
MFEEQTRMPLIGDKFPELEVKTTFGPMKLPDDFNGKWVVFFSHPGDFTPVCTTEFVAFQKRFDEFKALNTELIGLSVDQVPSHIKWVQWIKDNLGVEIQFPIIADELGRIAKALGLIHPAKGTNTVRAVYIVDPKGIIRAILYYPQEIGRNIDEIIRMIKAFQTADANHVAIPANWPNNELMGDEVIIPLPPDIKGAEERMNQPNCYDWWLCHKKI

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Crispr_ID: NC_011295_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011295_2

42877-42974

Orphan

Consensus_repeat	Method
GGTTTCAGCTGGATATATAGAGGAGTGGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_011295_2

>merge|NC_011295|2|42877-42974|CRISPRCasFinder
GGTTTCAGCTGGATATATAGAGGAGTGGAACTCGAAAACGCCAAGAAAATGGGCGCAATGAACATACGGTTTCAGCTGGATATATAGAGGAGTGGAAC

>NC_011295|2|2|42877-42974|CRISPRCasFinder
GGTTTCAGCTGGATATATAGAGGAGTGGAAC	TCGAAAACGCCAAGAAAATGGGCGCAATGAACATAC
GGTTTCAGCTGGATATATAGAGGAGTGGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011295.1\|WP_012544192.1\|48526_49396_+\|cysteine-synthase-family-protein	unknown	unknown	gnl\|CDD\|107204
NC_011295.1\|WP_041735898.1\|45842_46712_+\|DUF1028-domain-containing-protein	unknown	unknown	gnl\|CDD\|377639
NC_011295.1\|WP_143708141.1\|41699_42797_+\|DNA-recombination-protein-RmuC	unknown	unknown	gnl\|CDD\|224241
NC_011295.1\|WP_143708063.1\|50441_52427_+\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|223288
NC_011295.1\|WP_143708062.1\|41233_41584_+\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_012543591.1\|49710_50361_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|237297
NC_011295.1\|WP_012544159.1\|52896_54741_-\|aldehyde-ferredoxin-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|225277
NC_011295.1\|WP_012544876.1\|44217_45033_+\|TIGR02391-family-protein	unknown	unknown	gnl\|CDD\|378194
NC_011295.1\|WP_012543985.1\|37764_38361_+\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_041735494.1\|39256_39604_+\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_143708142.1\|43236_44091_+\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NC_011295.1\|WP_083760203.1\|36536_36713_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225080
NC_011295.1\|WP_012544402.1\|46921_47743_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381297
NC_011295.1\|WP_012543837.1\|47960_48530_+\|serine-acetyltransferase	unknown	unknown	gnl\|CDD\|223975
NC_011295.1\|WP_041735493.1\|38361_38949_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372757
NC_011295.1\|WP_012544727.1\|36884_37751_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|234698
NC_011295.1\|WP_012543836.1\|36325_36595_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377924
NC_011295.1\|WP_143708143.1\|52619_52889_-\|MoaD-family-protein	unknown	unknown	gnl\|CDD\|224888
NC_011295.1\|WP_012543622.1\|39588_40935_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133045
NC_011295.1\|WP_012544661.1\|39042_39192_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378383

Protein	Function_ID	Function_description	E-value
NC_011295.1\|WP_012544192.1\|48526_49396_+\|cysteine-synthase-family-protein	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	4.73948e-122
NC_011295.1\|WP_012544876.1\|44217_45033_+\|TIGR02391-family-protein	gnl\|CDD\|378194	pfam09509, Hypoth_Ymh, Protein of unknown function (Hypoth_ymh). This entry consists of a relatively rare prokaryotic protein family (about 8 occurrences per 200 genomes). Genes for members of this family appear to be associated variously with phage and plasmid regions, restriction system loci, transposons, and housekeeping genes. Their function is unknown.	1.44634e-52
NC_011295.1\|WP_143708141.1\|41699_42797_+\|DNA-recombination-protein-RmuC	gnl\|CDD\|224241	COG1322, COG1322, Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only].	7.47689e-89
NC_011295.1\|WP_143708063.1\|50441_52427_+\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	3.79893e-146
NC_011295.1\|WP_012543591.1\|49710_50361_+\|peroxiredoxin	gnl\|CDD\|237297	PRK13189, PRK13189, peroxiredoxin; Provisional.	1.64265e-145
NC_011295.1\|WP_012544159.1\|52896_54741_-\|aldehyde-ferredoxin-oxidoreductase-family-protein	gnl\|CDD\|225277	COG2414, COG2414, Aldehyde:ferredoxin oxidoreductase [Energy production and conversion].	0
NC_011295.1\|WP_041735898.1\|45842_46712_+\|DUF1028-domain-containing-protein	gnl\|CDD\|377639	pfam06267, DUF1028, Family of unknown function (DUF1028). Family of bacterial and archaeal proteins with unknown function. Some members are associated with a C-terminal peptidoglycan binding domain. So perhaps this could be an enzyme involved in peptidoglycan metabolism.	7.22028e-109
NC_011295.1\|WP_143708142.1\|43236_44091_+\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	3.48521e-31
NC_011295.1\|WP_083760203.1\|36536_36713_+\|hypothetical-protein	gnl\|CDD\|225080	COG2169, Ada, Adenosine deaminase [Nucleotide transport and metabolism].	8.24483e-09
NC_011295.1\|WP_012544402.1\|46921_47743_+\|aldo/keto-reductase	gnl\|CDD\|381297	cd19071, AKR_AKR1-5-like, AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.	8.22973e-135
NC_011295.1\|WP_012543837.1\|47960_48530_+\|serine-acetyltransferase	gnl\|CDD\|223975	COG1045, CysE, Serine acetyltransferase [Amino acid transport and metabolism].	1.22425e-60
NC_011295.1\|WP_041735493.1\|38361_38949_+\|hypothetical-protein	gnl\|CDD\|372757	pfam13851, GAS, Growth-arrest specific micro-tubule binding. This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.	0.00104606
NC_011295.1\|WP_012544727.1\|36884_37751_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	3.33636e-76
NC_011295.1\|WP_012543836.1\|36325_36595_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	5.5746e-13
NC_011295.1\|WP_143708143.1\|52619_52889_-\|MoaD-family-protein	gnl\|CDD\|224888	COG1977, MoaD, Molybdopterin converting factor, small subunit [Coenzyme metabolism].	6.8202e-16
NC_011295.1\|WP_012543622.1\|39588_40935_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133045	cd06423, CESA_like, CESA_like is the cellulose synthase superfamily. The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.	1.54614e-53
NC_011295.1\|WP_012544661.1\|39042_39192_+\|hypothetical-protein	gnl\|CDD\|378383	pfam10087, DUF2325, Uncharacterized protein conserved in bacteria (DUF2325). Members of this family of hypothetical bacterial proteins have no known function.	9.97147e-05

>NC_011295.1|WP_143708141.1|41699_42797_+|DNA-recombination-protein-RmuC
MNSTITKNISEMGISQQNLIKNFSDTVSSLADKTEERLNRMRDTIEAKLKEIQDENSSKLEQMRQTVDEKLQSTLNARISESFKLVSERLEQVHSGLGEVQSLVNDVGDLKKVLSNIKTRGILGEDQLEAIIEDILVPGQYEKNVIVRPGSREVVEFAVKIPVENGGNGSYMWLPIDAKFPMEDFERLIDAEERCDTAECERLRKELENRLKQCAKDIRDKYIDPPNTTDFAIMFLPAESLFAEALRKPGFIEVLQRECRVLITGPTTLSAVLNSLRQGFKIFAIEKKAEEVWKLLGAVKTEVGKFGDLLEKVNKKLQEAQNVIEDASRKTRTIDRKLRNVEEISPEETAELLALSPSSPDDDAF
>NC_011295.1|WP_143708062.1|41233_41584_+|hypothetical-protein
MKKNFSVIWGKFTIRKEKLTKGKHAILAIVWIYIETPLCYESGYFFSEHINFLSRKTLFAIELRKYEITIGGTEIAGYVFIAIYFSCDYCTFANCYICGGNEAQRRSGTNKIPNGA
>NC_011295.1|WP_012543622.1|39588_40935_+|glycosyltransferase-family-2-protein
METRLNTETKLPPSYKTVYIPVIYKFFIAQSIAFTWMIFSIRISIPWLKDLSSVVGLPLAVFIIAFIAYIPGYLVAFVAVSLLLDRQPPFKEKNPDLHVTILIAARNEAAKIRNTLKYIANQDYNGKIDVIIVDNNSTDGTLEAAQKAANEYGLNCTFLFEPKAGKSYALNTGLKAIKTEYFMTLDADTLLHKKAVNNIVARILSSPSDVCAVAGHVLARNSRDNILTRMQEWDYFLGIASLKRMQGLYQGTLVAQGAFSLYKTDVVREVGGWDDVIGEDIVLTWKFFEKGYRVFFEPLAIAFTEVPNRFKHFTRQRSRWTRGMLEGLKKAGPWKQERFLAIFLLGIDILIPLIDLAFTIFWIPGLVLAFFGKYYIVGPYTLLVLPLNVLVTVIMYSFQKNIFDALGLRVRRNRIGYTFYLLFYQIIHSPISVMGYIQEIFKLERVWK
>NC_011295.1|WP_041735494.1|39256_39604_+|hypothetical-protein
MCGVEVDDNLLSEKPCSIPTAHYVVFDELPEYADVYWVISVSNFRAALLAGKQVPGGMRYVSVSVKDDCLVEQLEDILLTSVEASGGARNISGFYGISDKLANLLLREASPWKQD
>NC_011295.1|WP_012544661.1|39042_39192_+|hypothetical-protein
MLTRLCSHEVMWAAKEYVADTGKPIAFSRASGVEGIVREVYKLLTEKEE
>NC_011295.1|WP_041735493.1|38361_38949_+|hypothetical-protein
MPIDTWPIEEYVRVYGRERITWLLLNLPLPEELERYRTEKLAAVIPKKSSGPQAVLWERIKQLGDELTRQRRRAENLAKQLFEEHAEKARLSEELHVLRKEIEQLKNNSQSATRNIDDVLRIKRLKTLISELREENTKLRRQLEELGIKEVQDIEGEYEERNDEAVEAVGKTQDIEEDVLGRIRNKNVAVYGRVG
>NC_011295.1|WP_012543985.1|37764_38361_+|hypothetical-protein
MLHLQLYFERFCRKCKKRIAVLVHDYGTINSIDEADQKLGNLNIPVMPIRCPQCGGEDWPEYALAHDATRNVTFQRIAIGTEDLPIVGGSVPYAHVRSPEEQAELERGLAKLKDFFSEREGKFWDEYCRWAVERWNEALKWLADIEWRKAYKELGIGIGANSGPAAYRKDAEKRFITQEEKERFWRTANSHLVYFELL
>NC_011295.1|WP_012544727.1|36884_37751_+|tyrosine-type-recombinase/integrase
MLELYHEYLVKKGKSPHTIKNYISDLMQFQKWFEESTGEQFSPGKITEIDVRSYRSYLINIRQLKPSSIKRKLEAIRKFLDWTVKQDIISKNPAKEVEAPASVTLPPRSLSEKEFLRLRRSFYKEGNERDIAIFEVLANTGIRVSELCSLKLSDVQISERKGKLIVRYGKGQKYREVPLNSDARKALNEYLKSRADENNERLFLGERGPLTPSGVFRIIKRYARDAGVEVSPHQLRHTFARRLLQSGADIVTVQQILGHANLNTTAVYLKPDYAEQEEAVEKISKLHL
>NC_011295.1|WP_083760203.1|36536_36713_+|hypothetical-protein
MVIQKPLQPKKYVGSIESNKYHLPTCRVEQIKPENRIWFDSEEEAQKAGYEPCKVCNP
>NC_011295.1|WP_012543836.1|36325_36595_+|copper-amine-oxidase-N-terminal-domain-containing-protein
MRDRASKYAITAIVIFFFLLSLQLPVLAAAPKIIIDGTELKIDANPVVVDGRTLVPLRGIFEALGAIISWDGNTKTITAQKICGEHRKQ
>NC_011295.1|WP_143708142.1|43236_44091_+|thermonuclease-family-protein
MLILIAGLLAACGNEAAPTPPAAGKTAEAASNAQHVEAVSSSGSKQPKQEQQPTVEKPAAGDKIEQVTSTENEKAEEGIELIKAKVTKAVDGDTVYVKLESDKEEKVRFIGVDTPESTTKVEPYGKEATAYTKSKLLNKDVWLELDVQERDKYGRLLAYVWLSPPTKESDEEIRTKMFNAVLLLEGYAQVMTVPPNVKYAEYFRKYQQEAMEKSAGLWGLEVKEEKPAFSQAVSASYIGNKNSKKFHLPDCQWTEKIAPGNRVYFKSRDEAIKAGYEPCKVCKP
>NC_011295.1|WP_012544876.1|44217_45033_+|TIGR02391-family-protein
MGTSDENKTLKLFSLSALEKLADIVADYHTGSGITELFRKAGFPEIRHDGSTKRWFVYQALQQVHQQHYGPYNVLKVIEALCNPEEFIGKPQVQQQVLEKVNEILRFYDLFVGEDGKVRRTSETETALTTRLLEGRRFDERGFHPEIRKHARQLFLEGYYFHAVLECCKALEKFVREKSGINKHGAELMSAALNLNNGPLKLNSQRTESERNEQEGVMHLCIGLMRAIRNPASHEPALDWTITREDALDLLSLISYLFRQIEQAVYFRIRN
>NC_011295.1|WP_041735898.1|45842_46712_+|DUF1028-domain-containing-protein
MRNISTFSIVARDPKTGELGIAVQSKFLAVGAVVPWAKAGVGAIATQAAANLDYGELGLKLLKKGYSPQAVLDALLALDDGREDRQVGIVDANGNSVTYTGENCFPWAGGIAGQDFACQGNILVSEATVNALKETFLSTEGPLAKRLVTALDAAQDAGGDRRGRQSAALLVVKEKGSYGGYNDRYIDLRVDDHPDPIKELIRLLDLYNMYFSKTTEGEKVKVTPEIVSSMQEALRNLGYYDGPVSGAFDEKTKNAYKNFCEFENFEERLCEGNFVDKRVIEFLLNKGKA
>NC_011295.1|WP_012544402.1|46921_47743_+|aldo/keto-reductase
MSVLTETYVLHNGVKIPKIGFGTWQIPNGEVAYNSVSYALEVGYRHVDTAYVYGNEESVGKAIRESGIPRDQIFVTSKLPADVKTYDGTLDYFERTLRNLNMDYLDLYLIHWPWPWNEKGKDYKKENIEVWHAMEELYKSGRIRAIGVSNFDVEYLQVLMDNCSVKPMVNQIRFFIGNTQEEITQFCQQNGILVEAYSPLATGRLIENDTIKKIADKYNKTVAQICIRYVIQRNALPLPKSTTPSRIKENADVDFEISPEDMEYLNSLKDTVE
>NC_011295.1|WP_012543837.1|47960_48530_+|serine-acetyltransferase
MRLYILGTELKKARNALKEDRQALLKSDPSIETPADIRFHAGYRSLRLYRYAHAFYVAGFRNVSAFIHFISRVLYAVDIHPAAEIEPGVVVDHGMGVVIGSTAKVGSGTVIYHGVTLGAKNITTGKRHPQVGKNVFIGAGATLLGAINVGDGARIGAGSVVVEDVPPYSTVVGVPAKVVKQDCVKEVVA
>NC_011295.1|WP_012544192.1|48526_49396_+|cysteine-synthase-family-protein
MIGIMETPLVCIEPYGIYAKLERFNPTGSIKDRPAYFMLVHALKENLIQPGGTLVEPTSGNTGISLAALGSQVGIKVILTMPASVTPERVKLAQSYGAEVILTPAEKGIPGAIEKAKQLQEKHHAYIPDQFNNPFNVLAHELTTGPEILKQTNWEVDAFVAGVGSGGTISGVGRALRRVLGNRVKIIAVEPAESPVLSGGKGGSHIIQGIGAGFIPTIFDKDLVDEIITVRGNEALEGVKMLSAKGYSVGISSGANFIAALRIKEKYNLAHVVTVFPDDGLKYLSTIAY
>NC_011295.1|WP_012543591.1|49710_50361_+|peroxiredoxin
MFEEQTRMPLIGDKFPELEVKTTFGPMKLPDDFNGKWVVFFSHPGDFTPVCTTEFVAFQKRFDEFKALNTELIGLSVDQVPSHIKWVQWIKDNLGVEIQFPIIADELGRIAKALGLIHPAKGTNTVRAVYIVDPKGIIRAILYYPQEIGRNIDEIIRMIKAFQTADANHVAIPANWPNNELMGDEVIIPLPPDIKGAEERMNQPNCYDWWLCHKKI
>NC_011295.1|WP_143708063.1|50441_52427_+|UvrD-helicase-domain-containing-protein
MDSVDLSKLNEAQKQAVTAPPKPLAIIAGPGSGKTRVLTYRALFAVKEWHLPPERILAITFTNKAADELKERLGRLIPEGDRIFAATMHSFAARMLRYFAPYAGISQNFVIYDDDDSKGLIEDILKQMNMDTKRFRPNDVLNHISAAKARMFDCNTFPEFIRQRYGSWGYYFDTVHQVFMTYERLKEQSQALDFDDLIMVLAQRMEDRPELREMIAGLFDLVMVDEFQDTNFAQYQMLLYMTNPHYSGMNNVTIVGDPDQSIYGFRAAEYYNIKRFIDDYNPEVVFLDLNYRSNRTIVDSASALINDSPSALFERKLESIKGAGNKLILRRPFDDADAAITAAFEVQRLHKMGIPYEEIAVLMRTRALTARVEREFATRNIQYHIIGGVPFFARREIKDILAYLRLSRNAMDRVSLKRILTMKKRGFGTASLEKLFNFAEENKLTLLEAMKAAVESLLFKKLSMNDYLESLYTLIQTIQEIAEPSQAIYLVMEQENLLDHFRSISKSEEEYIERTENVKQLISIAEESADMDDFLQRSALGTRENNGGVEGVAISTVHGVKGLEFQAVILYYVTDGFFPHSLSVTTAEKEEERRLLYVAMTRAKEHLIFYVPYKQPWGNGFEQMARPSPFLRSIPKELWDGKPNEIESLYAPYSPQQKWSE
>NC_011295.1|WP_143708143.1|52619_52889_-|MoaD-family-protein
MLVNVLYFGHLREATLKEKETLEVPSEATLATLIELLEQKYGPEYRNAMDAIKGLRILIDGRDSSILGGTDAPLKEGCTVVFLPPIAGG
>NC_011295.1|WP_012544159.1|52896_54741_-|aldehyde-ferredoxin-oxidoreductase-family-protein
MQGGYMNRILRVDLSNRTWTTEELDEKLVRDYIGGRGFGAKFLYDDLKPGIDPLGEENEIIFIAGPLAATGAQSCARFEIYFKSPQTGGYFQSSGGGFFAPEMKFAGYDAIIIKGKSEKPVYLWIHDDKVEFKDASYLWGLGLADTEQLIREELNDPYVRVAAIGPAGENLVKYAGVFSDRRAAARGGGGAVMGSKNLKGVAVRGHQKVPIANNEAFQQALKAQVGAYKGNPMYEMMHTTGTQASELTAVLGMYPWKNFREAPGPEWEKLQASEFNKLRVRKMGCQNCMIRCSQITKVWDGPYKGVWSEGPEYETLWSFSGPIGKAEIGLTVLADRLCDDLGMDTISAGQSIGFAYELYEKGIITKEDTDGLELVYGNIEPVPRLIEMIARREGFGNVLAEGTKRMAEKYNQGSEYYAIQVKGLELPAYDPRGAKAHGLNLATSPLGADHNYGYGSQELFGVPIPHPVDRFAVEGKGEITKFNQDWAAFTETGILCTFASLMTGPDIFSQLLYGATGVEEFADPNYMWVVGERIVNLERMFNAREGFTREDDRMPERIVKDPLPYGPSAGQVFEQDELLDQYYEARGWDKVTGIPKAEKLRELGLDFTLDYAAQ

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Crispr_ID: NC_011295_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011295_3

1263870-1264966

Unclear

Consensus_repeat	Method
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	PILER-CR
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	CRISPRCasFinder
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	CRT

16 spacers

csa3

The CRISPR arrays of NC_011295_3

>merge|NC_011295|3|1263870-1264966|PILER-CR,CRISPRCasFinder,CRT
GTTTCAATCCCTTGTAGGTAAGCTAGAAACGCTTTCTTCGAGTCAATGGACTCTGTAACACGTTCCTTGAGTTTCAAACCCTTGTAGGTAAGCTAGAAACAAGCCTTGCTGTGAGAGAAGACTTTATATGCCAGGGGCGTTTCAATCCCTTGTAGGTAAGCTAGAAACCAATGAGTCTGGGGTTGAAATGAATAAGAGGAGCATGTTTCAATCCCTTGTAGGTAAGCTAGAAACCACGCTATGTCTTTAACACGCTGTTCCACCATCATAGTTTCAATCCCTTGTAGGTAAGCTAGAAACATGGCAGGAATTGTATTTCGTAGTGGCGAGCAAAAAGGTTTCAATCCCTTGTAGGTAAGCTAGAAACTTTTCAATTCCTGGTTGTACGACTCACCAATCTTCAGTTTCAATCCCTTGTAGGTAAGCTAGAAACTTTTTAACTGGAGGACTAATCCTCCAGTTCCTCCAAGTTTCAATCCCTTGTAGGTAAGCTAGAAACTGGATAGTTATGGCGATTCAATGTACAGCAATCATAAGTTTCAATCCCTTGTAGGTAAGCTAGAAACTTTAATTAGGCCGAAACAAGGATTTAAGGAATTGATGTTTCAATCCCTTGTAGGTAAGCTAGAAACCCGACGAGGTATTGTTGGGAAGAGTTAGGGAGTATAGTTTCAATCCCTTGTAGGTAAGCTAGAAACTTTTTTACGGTGAGAGAGAAGTGCTAAGGGGACATATGTTTCAATCCCTTGTAGGTAAGCTAGAAACTTTGCTTTTCAAAATGCCGAACGCAGACATAAGGCCGTTTCAATCCCTTGTAGGTAAGCTAGAAACATTTGCGAGAATGGTGCTTGCGATGTATTCACGATGTTTCAATCCCTTGTAGGTAAGCTAGAAACTACCTACACAACTGCTATGCTCACAAAACGACATGCCGGTTTCAATCCCTTGTAGGTAAGCTAGAAACTCTAAATTTTTTACACCTTCCTTACTCACGAAGTTTGTTTCAATCCCTTGTAGGTAAGCTAGAAACACTGAACCTTCACCGCGCCGAACTACCTCTTCATCGAGTTTCAATCCCTTGTAGGTAAGCTAGAAAC

>NC_011295|3|1|1263870-1264966|PILER-CR
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	GCTTTCTTCGAGTCAATGGACTCTGTAACACGTTCCTTGA
GTTTCAAACCCTTGTAGGTAAGCTAGAAAC	AAGCCTTGCTGTGAGAGAAGACTTTATATGCCAGGGGC
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	CAATGAGTCTGGGGTTGAAATGAATAAGAGGAGCAT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	CACGCTATGTCTTTAACACGCTGTTCCACCATCATA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	ATGGCAGGAATTGTATTTCGTAGTGGCGAGCAAAAAG
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTTCAATTCCTGGTTGTACGACTCACCAATCTTCA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTTTAACTGGAGGACTAATCCTCCAGTTCCTCCAA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TGGATAGTTATGGCGATTCAATGTACAGCAATCATAA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTAATTAGGCCGAAACAAGGATTTAAGGAATTGAT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	CCGACGAGGTATTGTTGGGAAGAGTTAGGGAGTATA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTTTTACGGTGAGAGAGAAGTGCTAAGGGGACATAT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTGCTTTTCAAAATGCCGAACGCAGACATAAGGCC
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	ATTTGCGAGAATGGTGCTTGCGATGTATTCACGAT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TACCTACACAACTGCTATGCTCACAAAACGACATGCCG
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TCTAAATTTTTTACACCTTCCTTACTCACGAAGTTT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	ACTGAACCTTCACCGCGCCGAACTACCTCTTCATCGA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC

>NC_011295|3|3|1263870-1264966|CRISPRCasFinder
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	GCTTTCTTCGAGTCAATGGACTCTGTAACACGTTCCTTGA
GTTTCAAACCCTTGTAGGTAAGCTAGAAAC	AAGCCTTGCTGTGAGAGAAGACTTTATATGCCAGGGGC
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	CAATGAGTCTGGGGTTGAAATGAATAAGAGGAGCAT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	CACGCTATGTCTTTAACACGCTGTTCCACCATCATA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	ATGGCAGGAATTGTATTTCGTAGTGGCGAGCAAAAAG
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTTCAATTCCTGGTTGTACGACTCACCAATCTTCA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTTTAACTGGAGGACTAATCCTCCAGTTCCTCCAA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TGGATAGTTATGGCGATTCAATGTACAGCAATCATAA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTAATTAGGCCGAAACAAGGATTTAAGGAATTGAT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	CCGACGAGGTATTGTTGGGAAGAGTTAGGGAGTATA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTTTTACGGTGAGAGAGAAGTGCTAAGGGGACATAT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTGCTTTTCAAAATGCCGAACGCAGACATAAGGCC
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	ATTTGCGAGAATGGTGCTTGCGATGTATTCACGAT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TACCTACACAACTGCTATGCTCACAAAACGACATGCCG
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TCTAAATTTTTTACACCTTCCTTACTCACGAAGTTT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	ACTGAACCTTCACCGCGCCGAACTACCTCTTCATCGA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC

>NC_011295|3|1|1263870-1264966|CRT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	GCTTTCTTCGAGTCAATGGACTCTGTAACACGTTCCTTGA
GTTTCAAACCCTTGTAGGTAAGCTAGAAAC	AAGCCTTGCTGTGAGAGAAGACTTTATATGCCAGGGGC
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	CAATGAGTCTGGGGTTGAAATGAATAAGAGGAGCAT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	CACGCTATGTCTTTAACACGCTGTTCCACCATCATA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	ATGGCAGGAATTGTATTTCGTAGTGGCGAGCAAAAAG
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTTCAATTCCTGGTTGTACGACTCACCAATCTTCA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTTTAACTGGAGGACTAATCCTCCAGTTCCTCCAA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TGGATAGTTATGGCGATTCAATGTACAGCAATCATAA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTAATTAGGCCGAAACAAGGATTTAAGGAATTGAT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	CCGACGAGGTATTGTTGGGAAGAGTTAGGGAGTATA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTTTTACGGTGAGAGAGAAGTGCTAAGGGGACATAT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TTTGCTTTTCAAAATGCCGAACGCAGACATAAGGCC
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	ATTTGCGAGAATGGTGCTTGCGATGTATTCACGAT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TACCTACACAACTGCTATGCTCACAAAACGACATGCCG
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	TCTAAATTTTTTACACCTTCCTTACTCACGAAGTTT
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC	ACTGAACCTTCACCGCGCCGAACTACCTCTTCATCGA
GTTTCAATCCCTTGTAGGTAAGCTAGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011295.1\|WP_158300397.1\|1266805_1266943_-\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_012543490.1\|1267197_1267893_-\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_158300398.1\|1267892_1270049_-\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341180
NC_011295.1\|WP_012544507.1\|1253976_1255149_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NC_011295.1\|WP_083760236.1\|1260945_1261200_-\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NC_011295.1\|WP_143708129.1\|1261790_1262609_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NC_011295.1\|WP_012544252.1\|1274709_1275642_-\|type-II-restriction-endonuclease	unknown	unknown	gnl\|CDD\|377384
NC_011295.1\|WP_143708185.1\|1270520_1272746_-\|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl\|CDD\|226581
NC_011295.1\|WP_012543863.1\|1255376_1257263_+\|aldehyde-ferredoxin-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|225277
NC_011295.1\|WP_012544542.1\|1265065_1266193_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173800
NC_011295.1\|WP_049750687.1\|1272840_1273224_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|227304
NC_011295.1\|WP_012544199.1\|1273721_1274705_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|334588
NC_011295.1\|WP_012544431.1\|1273216_1273417_-\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_012543825.1\|1266167_1266584_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377924
NC_011295.1\|WP_012544024.1\|1259911_1260925_-\|permease	unknown	unknown	gnl\|CDD\|223773
NC_011295.1\|WP_012544872.1\|1257317_1257764_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213216
NC_011295.1\|WP_012544369.1\|1263543_1263750_-\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_012544683.1\|1259507_1259861_-\|TM0996/MTH895-family-glutaredoxin-like-protein	unknown	unknown	gnl\|CDD\|379063
NC_011295.1\|WP_041735826.1\|1258202_1259231_+\|acyltransferase	unknown	unknown	gnl\|CDD\|376607
NC_011295.1\|WP_012543599.1\|1262722_1263145_-\|DUF296-domain-containing-protein	unknown	unknown	gnl\|CDD\|224575

Protein	Function_ID	Function_description	E-value
NC_011295.1\|WP_158300398.1\|1267892_1270049_-\|restriction-endonuclease-subunit-S	gnl\|CDD\|341180	cd17291, RMtype1_S_MgeORF438P-TRD-CR_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S.MgeORF438P TRD1-CR1 and TRD2-CR2, and to Escherichia coli G5 S subunit (S.Eco16445ORF5013P ) TRD2-CR2 and Acetobacter pasteurianus IFO 3283-01 S subunit (S2.Apa3283ORF14230P) TRD1-CR1. The recognition sequences of Mycoplasma genitalium G-37 S subunit (S.MgeORF438P), Escherichia coli G5 S subunit (S.Eco16445ORF5013P), and Acetobacter pasteurianus IFO 3283-01 S subunit (S2.Apa3283ORF14230P) are undetermined. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	8.16474e-64
NC_011295.1\|WP_012543599.1\|1262722_1263145_-\|DUF296-domain-containing-protein	gnl\|CDD\|224575	COG1661, COG1661, Predicted DNA-binding protein with PD1-like DNA-binding motif [General function prediction only].	1.71198e-26
NC_011295.1\|WP_083760236.1\|1260945_1261200_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	6.70714e-20
NC_011295.1\|WP_143708129.1\|1261790_1262609_-\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	5.40832e-45
NC_011295.1\|WP_012544252.1\|1274709_1275642_-\|type-II-restriction-endonuclease	gnl\|CDD\|377384	pfam04556, DpnII, DpnII restriction endonuclease. Members of this family are type II restriction enzymes (EC:3.1.21.4). They recognize the double-stranded unmethylated sequence GATC and cleave before G-1. http://rebase.neb.com/rebase/enz/DpnII.html.	5.85694e-125
NC_011295.1\|WP_143708185.1\|1270520_1272746_-\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|226581	COG4096, HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	4.55334e-91
NC_011295.1\|WP_012543863.1\|1255376_1257263_+\|aldehyde-ferredoxin-oxidoreductase-family-protein	gnl\|CDD\|225277	COG2414, COG2414, Aldehyde:ferredoxin oxidoreductase [Energy production and conversion].	0
NC_011295.1\|WP_012544542.1\|1265065_1266193_+\|S8-family-serine-peptidase	gnl\|CDD\|173800	cd07474, Peptidases_S8_subtilisin_Vpr-like, Peptidase S8 family domain in Vpr-like proteins. The maturation of the peptide antibiotic (lantibiotic) subtilin in Bacillus subtilis ATCC 6633 includes posttranslational modifications of the propeptide and proteolytic cleavage of the leader peptide. Vpr was identified as one of the proteases, along with WprA, that are capable of processing subtilin. Asp, Ser, His triadPeptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	3.01187e-13
NC_011295.1\|WP_049750687.1\|1272840_1273224_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|227304	COG4969, PilA, Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion].	5.14497e-09
NC_011295.1\|WP_012543825.1\|1266167_1266584_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	4.54953e-37
NC_011295.1\|WP_012544024.1\|1259911_1260925_-\|permease	gnl\|CDD\|223773	COG0701, COG0701, Predicted permeases [General function prediction only].	3.45608e-52
NC_011295.1\|WP_012544872.1\|1257317_1257764_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213216	cd03249, ABC_MTABC3_MDL1_MDL2, ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins. MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the yeast MDL1 (multidrug resistance-like protein 1) and MDL2 (multidrug resistance-like protein 2) transporters are also included in this CD. MDL1 is an ATP-dependent permease that acts as a high-copy suppressor of ATM1 and is thought to have a role in resistance to oxidative stress. Interestingly, subfamily B is more closely related to the carboxyl-terminal component of subfamily C than the two halves of ABCC molecules are with one another.	2.22659e-59
NC_011295.1\|WP_012544199.1\|1273721_1274705_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	1.94473e-14
NC_011295.1\|WP_012544683.1\|1259507_1259861_-\|TM0996/MTH895-family-glutaredoxin-like-protein	gnl\|CDD\|379063	pfam13192, Thioredoxin_3, Thioredoxin domain.	1.93856e-29
NC_011295.1\|WP_041735826.1\|1258202_1259231_+\|acyltransferase	gnl\|CDD\|376607	pfam01757, Acyl_transf_3, Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.	1.46052e-15
NC_011295.1\|WP_012544507.1\|1253976_1255149_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	0

>NC_011295.1|WP_012544369.1|1263543_1263750_-|hypothetical-protein
MLLKKGGCRKVVDPEIEAKAGKVFMNPTEEFSKHVPEDEFEWHHLPKFVAMKLNEAGVIVFGKWEREE
>NC_011295.1|WP_012543599.1|1262722_1263145_-|DUF296-domain-containing-protein
MTIKENNGIIAVRLHDGDKFMESLKAVAKDCGVNSAVLHGIGLFKNAELGYFNGHEYVTKSFYQQLMEVISLEGNISMAENGAEVVIHAHCVLGLPDYSLIGGHLMDGTFFNGELFIQKLEGIKLVRRSEPSGLNGLWVE
>NC_011295.1|WP_143708129.1|1261790_1262609_-|metallophosphoesterase
MRKRRKVLVVFFALFFFWLFENFKIVVSVTTISSPKIRSTVTIVQISDLHGYSFGLDNNYLLRAIEKQQPDIVAVTGDLFNRGDNRGKAKALNLIKVLSEEYPVYYVRGEHEGSSSVDDIGDAGATVLEYERVDVKVGETPISIYGCPTTGYYSSADNVLEAIKVEESNNYNILLAHIFYEEVFDKWKGDLILSGDTHGGSIRLPFLGPLKYNGITLPKLSYNGPVYDKGLFNLGDKYLYVSPGLGNFPLPLRLFNHPELTVIKLVSSTQGS
>NC_011295.1|WP_083760236.1|1260945_1261200_-|helix-turn-helix-transcriptional-regulator
MLSLLNDGEKCACKLLEKLSISQPTLSHHMKILCDSGLVKSRNEGKWVHYSIDPAGFALAQQFLGQLSRFNIADPVCCSKSSTT
>NC_011295.1|WP_012544024.1|1259911_1260925_-|permease
MQVLAAVWSFFQNQILGMKWLSSVVYSALNALGLDMNTRVGGVIHFFVYDLAKIFLLLSVLIFVISYVQSYFPPERTKKIVGRSHGIWANILAALLGTVTPFCSCSSIPLFIGFTNAGLPVGVTFSFLISSPLVDLGSLVLLMSIFGLRVAVMYVVIGVLLAVVGGTLIEVFGMDKHVYSFVKDTKAADIDPPSLTVTDRLIFARDQVRDIVHRVGRYVVIGVAIGAVIHNVIPATWISSILGRKNNGAVILATLVGVPIYGDIFGSIPVAESLFAKGAGLGTVLSFMMAVTALSLPSMVMLSKVVKLKLLVLFIAIVTGGIMVVGYIFNALQAVLI
>NC_011295.1|WP_012544683.1|1259507_1259861_-|TM0996/MTH895-family-glutaredoxin-like-protein
MHQEKPENQTSSFSEGTPNLDHEQENCVRNDSNPAVLSVKVLGPGCARCKALEANTKSALDKLGLKADFNHVTDFSQIAAYGIMSTPALVINEKVVSFGRVLSAEEVVKILRSELQL
>NC_011295.1|WP_041735826.1|1258202_1259231_+|acyltransferase
MKRLREFDVLKGLSITAVILIHVTSHGVGTFDPTSTSYFVYLILNRLSQFAVPTFIFASCVLLSYIHGDDFRTITAGGLKAFYSKRFVRIIPPYLIWTLVYLVVKHIESNGTVRVTWGNYLNLLLRGDGYYHLYFVVVILQVYILLPFIMYVVSHLKVRFRQILLISIGVQVACYYLYEFYIIHYFPRGTRLMIWYLAVILVGVWIGENYEEYCKRERHVTIFLPAALVSGVLYTYFYHLSNIGQPVSSGIVNLWWYIYVSSTPLLLLYISKKVNIRFFERAGQLSFGIFLMHPLFLFIMNRIYATVNVILYDIFVFFIIYSLSYIITKWLEATPWGKYIVG
>NC_011295.1|WP_012544872.1|1257317_1257764_-|ATP-binding-cassette-domain-containing-protein
MTIKENILLDDEFTEEEFFDAVRKSKVNKFVYLLENGYDTVVGERGGKLSDGQRQRIAIARAVIRKPKILVLDEATSGVDSQTEEEIFDELKEEDMTLIIISHRLSTIRKADRVLVLNEGRVVEEGTHEELMASSCVYKDIIESQLVV
>NC_011295.1|WP_012543863.1|1255376_1257263_+|aldehyde-ferredoxin-oxidoreductase-family-protein
MKGTLGKVLEVDLSSKTVEMRPIEDKTMYDYLGGLGLATRLLFDQTRPQIDALSEENVLVIAPGLLVGSGLPTASKTTLTFKSPLTNGFGRSVAGAYLGVELKKAGYDALVIKGKSDKPVYLFIDDDHVEIRDASHLWGKDAIETQELLKAELGNVRTGAIGYAGEKLSKISGVDFEERQAGRAGGGAVMGSKMLKAIAVRGTKNIPYANVEALRETIKKWNQKIVGSPVQELDMKYGSGEFYEWVNKIMGVFPVKNWQQSYFEDSFNAHPDGKSPLDPYYWAPLYTEKHHPCPNCNKPCGRHIVFKEGKYAPLRVEGVEYELLYSLGGALGIDDIEVTAKLNSICDRAGLDGISAGVTLAWAMEAYERGLLTKEDTDGLDLRFGNSDAAVAAMEKLANREGKLGELLSNGVKEASRKLGKGSEKFALEVKGLEPPAYDVRGLKGMALALAVSVRGACHLTGGIYAPELTGSFWEFSNIDRLSSEWKGYEVKTGEDFMTVYDVLGLCKFSRSLFWLEEDVVDAIEAVTGIRFTIEQLMAIGERIYNLQRLFNIREGFTRKDDYLPYRVTHEPISNGVTKGSYVSEEELQDMLDQYYMARGWSKEGVPTKMHLKRLGLVEEAEVFGAPI
>NC_011295.1|WP_012544507.1|1253976_1255149_+|thiolase-family-protein
MNEVFISMPLRTAISKFGGSLKDIPAPEIAGKVINAILEETHLPPDAFDDVVLGNVIQAGEKMNAARQAAIYGGISDSVPAMVVNRVCGSGLQAVITAAMEIQSGYASCVLAGGMENMDKAPYILSNGRYGARMGDTTLYDAMLMDGLNDAFTGKHSGLITDEYLVPKYGVTREEQDQFAYESHMKAAKAIQEGKFSSQIVPIQVSKEFVFQVDENVRPDTTLERLAKLRPAFKEGGTITAGNAPSLNSGAAAMVLSTEKVANKFNLPVFGRILSCAVSAVDPNFFGIAPIPAVKNALEKASLSINDIDLFEINEAFAAIAIVVQRELSIPEEKLNVNGGAVALGHPIGASGAMLVTKILYELRNRQAKLGCVSLCIGGGQGIALIVERV
>NC_011295.1|WP_012544542.1|1265065_1266193_+|S8-family-serine-peptidase
MLGYVGYPATFMRYYNMFGGTSCSAPFAGAVATLVKQAHKDWTAEQVRASLMNTASVLYNKVTGEPISVMIQGSGLIDGVAAVKTPALISPYEIDMTATGLHPVVLTVKNVSDATLTFTVTVQPTLGNFEYGQNDGLTLSLTSSRIIVSPRLSATLGLTAKADLSKLTKGSHEALIWFSNGTATLHVPMLIWNDLNTIWWERSNPFDAGYNSKLPPKLINVRATKLPNSSDVAIDFTLNRGSISGSSWGSPEPYWSNYADEIRVDIVNQSGATVATVFDKGHLLIGHYRAVWNGKDSNGQPVPAGEYKYVITVTDYFTNFDIPIIDTDTQYTGYITVGNNATLTPSLTVTASSFAYIPANYQSKNSYSAYHTCTA
>NC_011295.1|WP_012543825.1|1266167_1266584_+|copper-amine-oxidase-N-terminal-domain-containing-protein
MPITPAPLSIIELQIGNPVFKLNNQALLLDSPPVIKNDRTLLPIRAVVEAMGGQVNWNAEERRVDIEYRGKTVTLWIGKNTAKVNGKEVMIDPSNPNVVPEIINGRTMLPLRFVAEALGCEVKWDDATKTITILFPSY
>NC_011295.1|WP_158300397.1|1266805_1266943_-|hypothetical-protein
MNGSESKFKRFLNTEEELEAFYSEVVSTVQSDLAQQVYTAHRSTK
>NC_011295.1|WP_012543490.1|1267197_1267893_-|hypothetical-protein
MHTSVILSEALRYFIDSEHFELSVVLFAVAVERLMKQRLCELDDVLVLDKNNSVEHLVRFKKLQDKVKNIQSRQNLMTRKERRETFLTIPYNEVISRYEAMFNLNIEEDEAVTDKHELKRIREERDRRKAALVRLGNMRNNIVHYFEYYFNPVDEGLFILNEILPFIREMIQEVSDAYKYEDIFNETVFEKLKAKEEELTRQQSDTLSQKIREKKEEYSELNPELIEERKK
>NC_011295.1|WP_158300398.1|1267892_1270049_-|restriction-endonuclease-subunit-S
MNKILTLWAEHTNLLFKSLANKNSTVSILLLATSFISWWNLLTREIGEKIYDPAAGTGGFILRAFEVVKSKIDNLVKAGMRVNESTAAYNGVQFDEAEMLYRKLKEESLYAVEKAPDVYKLALMNMILHNDGKSNLFEADSLDNRAQLEHKEKYDVVLTNPPYGPLAQSRVGTFEFHAKRYEALFIQHIMAALRPSEPGKKRSRAVVIILDKILFDNSSVFKNIRMKLLREFDLKAVFSMPAGIFQPYSGVKTTVLYFEKPTKEEWDETKKQNAYTTKQVLFVDVKEDGFTLTTQRRPINGAFQGDDPNIYEPPCGNLPKAVEVFRRWIDWLNNPTKELPDFIDNDFCWTATIEEIKTKDYNLNPGLYRKTIKGKQKWEVVSLREICDIQKGTSITKADTVEGNVPVIAGGQEPAYYHNQSNRDGNIITVSASGAYAGFVNYFDIPIFASDCTTIKSNDEEKALTKYIFYILKSRQEDLYKLQRGAGQPHVYPNDLANIQIPLPPLPVQQELVARLDKQQAIIEQCNAMEKTILEAGIDDSIFEGDWEWVELGELIALRNGISISNTLVSNRGKYPVCGSNGIYGYTDNNDKLLFGETIVVGRVGAYCGNVHYYDVPIWVTDNAIVVTVTNKDKLKTKYLYYFLLSKDLGKYANVTGQPYISQSIISSLKVPLPPIEKQQKIVDFLNVQFETLTNIRRLKENAKQTIKMILDREVFGE
>NC_011295.1|WP_143708185.1|1270520_1272746_-|DEAD/DEAH-box-helicase-family-protein
MNTEENAKSLIDEHLRALNWNLADFTQITKEYPIPGGERADYAILVNSLPVAIIEAKKQGMDLNAALAQAKNYAKKLNESGKEVFLIFASDGKVFYRQNLKANTRPEKISRLMTYAEIKDFLNPETDILLAGLRNYQKIAVSQVVSAFQLGRDRTYIEMATGTGKTITAAGIISKLYKVGLVRRVLFLVDRDSLAEQTVRSFNKVLGDTFKINRLTGTKEDKYNDISVSTIQFLYVNDKYRAYPNNFFDLVILDECHRSYFGDWHTVIEHFRTGKAKVLGLTATPSDKETQSTDDYFGEPVFRYSYYQGVKDGILAFTERYKFLTNVDLSGIHDMGFDFEPEDLGRRVDVPRRNELIAEKYFEVIGYEQTHTIPKTLVFAASIAHANHLRDALITKYNELNKLPKDSSEAEDFIVVIHNQVRNASELIRKFQEIDSEIRIAVSVDMLSTGIDAPDIEVLVMARPTKSKILYVQMKGRATRKCNEQEHGKTKESFKLIDFVDLAGIEEVVTDETLETDEIIDTTEETEVSSDGEKIPSDKEDGEGKEPKETEKIEMVIADVPVWIVKSEVITSSAFDHIRKQIEPQLKAIKEKTVLKERFVQAVLSWEALNPGIPVDEKYLEAFGFDISTLRDIYGEVTATYKDFIDVALGKTRFKTVEEKNRDAVIAHLKEKKHLNDEQVEFIMMFYDFKKRNPALTFTQFSNSQLLQQKGGIARIKGLFGSLDKFVQLYDEIKAVSFLDV
>NC_011295.1|WP_049750687.1|1272840_1273224_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MCRINKGFTLIELMLVVAVIVLLVAVVIPMYRDYTERAKQASFCATVHNIETLLYRWRAEKLTDSYPTLDELNTLLTSATYFTTEPINPYTNKSLVITATLTDKEGSISYTKTPTGYILESSPACGR
>NC_011295.1|WP_012544431.1|1273216_1273417_-|hypothetical-protein
MFVKPLTNNSCSQYDLQFALYPEYVEQLGESFTFADAYKLVQKKLTSEITKEERKVKAGLEQLSHV
>NC_011295.1|WP_012544199.1|1273721_1274705_-|methyltransferase-domain-containing-protein
MSLKVKCPICGYKCTKTEYAKHLESYHVEDYQRIVDEINKDIKNGMSIKDVAQKNSLTERFVKGVLGYRTLVKEEMTNYNVSKAKTEIWEPEDFSLETTTVWGFPDRGDWATHSGKYRGNWSPYIPRNVILRYSNENDVVLDQFVGSGTTLVEAKLLGRRGLGVDINPDAVKLALSNVNFEHKCGLADVHIGDARNLDFVKDSSIDLICTHPPYSNIIKYSDNIEGDLSHYDIPEFLKEMYKVASESYRVLKRGRFCAVLMGDTRRKGNIIPLGFRVMEVFCKAGLTLKEIVIKEQHNCTSTGYWKKQSIKYNFLLIAHEYLFIFKK
>NC_011295.1|WP_012544252.1|1274709_1275642_-|type-II-restriction-endonuclease
MKYSNLFYKLISCKDEDDVFEYLIRNLKETIISWDFFVAWEKVINKVEDIEISLNLLNYLVGKENITEKFAELVSKYPEVIDVLPVLVAWRAKNVKVLDPLDDNIFNYKEYSFEKKSSYTTEEIASLTEFADKTGLLAMFKNENIKSVVDYVTGVEVGLDTNARKNRSGAAMEMITELLIKRICAKNRYNYISQATAHKINELFGYEVKVDKSERSFDFAIDNGDKLYLVETNYYGGGGSKLKAVAGEFVTLCRFLKRETPQHTFIWITDGLGWKTAKKPLREAFDEVDYILNLSMLENGVLENIILEGL

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Crispr_ID: NC_011295_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011295_4

1273430-1273524

Unclear

Consensus_repeat	Method
AATGTTTCAATCCCTTGTAGGTAAGCTA	CRISPRCasFinder

1 spacers

cas2,cas1

The CRISPR arrays of NC_011295_4

>merge|NC_011295|4|1273430-1273524|CRISPRCasFinder
AATGTTTCAATCCCTTGTAGGTAAGCTAGAAACTACGTCAACCAATTGTCAGCACCATCCCAGGCTTAATGTTTCAATCCCTTGTAGGTAAGCTA

>NC_011295|4|4|1273430-1273524|CRISPRCasFinder
AATGTTTCAATCCCTTGTAGGTAAGCTA	GAAACTACGTCAACCAATTGTCAGCACCATCCCAGGCTT
AATGTTTCAATCCCTTGTAGGTAAGCTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_011295.1\|WP_158300397.1\|1266805_1266943_-\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_012544769.1\|1281308_1281473_-\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_012544199.1\|1273721_1274705_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|334588
NC_011295.1\|WP_158300398.1\|1267892_1270049_-\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341180
NC_011295.1\|WP_012543599.1\|1262722_1263145_-\|DUF296-domain-containing-protein	unknown	unknown	gnl\|CDD\|224575
NC_011295.1\|WP_012544435.1\|1276962_1277226_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NC_011295.1\|WP_012543803.1\|1275631_1276579_-\|DNA-adenine-methylase	unknown	unknown	gnl\|CDD\|273146
NC_011295.1\|WP_143708185.1\|1270520_1272746_-\|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl\|CDD\|226581
NC_011295.1\|WP_012543490.1\|1267197_1267893_-\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_049750687.1\|1272840_1273224_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|227304
NC_011295.1\|WP_012544542.1\|1265065_1266193_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173800
NC_011295.1\|WP_012544431.1\|1273216_1273417_-\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_143708132.1\|1279175_1281179_-\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_143708131.1\|1277621_1279121_+\|phosphodiester-glycosidase-family-protein	unknown	unknown	gnl\|CDD\|377924
NC_011295.1\|WP_012543825.1\|1266167_1266584_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377924
NC_011295.1\|WP_012544252.1\|1274709_1275642_-\|type-II-restriction-endonuclease	unknown	unknown	gnl\|CDD\|377384
NC_011295.1\|WP_143708133.1\|1281796_1284241_-\|peptidase-M56	unknown	unknown	gnl\|CDD\|310280
NC_011295.1\|WP_012543976.1\|1277235_1277385_-\|hypothetical-protein	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NC_011295.1\|WP_012544369.1\|1263543_1263750_-\|hypothetical-protein	unknown	unknown	unknown
NC_011295.1\|WP_012544000.1\|1284243_1284630_-\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747

Protein	Function_ID	Function_description	E-value
NC_011295.1\|WP_158300398.1\|1267892_1270049_-\|restriction-endonuclease-subunit-S	gnl\|CDD\|341180	cd17291, RMtype1_S_MgeORF438P-TRD-CR_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S.MgeORF438P TRD1-CR1 and TRD2-CR2, and to Escherichia coli G5 S subunit (S.Eco16445ORF5013P ) TRD2-CR2 and Acetobacter pasteurianus IFO 3283-01 S subunit (S2.Apa3283ORF14230P) TRD1-CR1. The recognition sequences of Mycoplasma genitalium G-37 S subunit (S.MgeORF438P), Escherichia coli G5 S subunit (S.Eco16445ORF5013P), and Acetobacter pasteurianus IFO 3283-01 S subunit (S2.Apa3283ORF14230P) are undetermined. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	8.16474e-64
NC_011295.1\|WP_012543599.1\|1262722_1263145_-\|DUF296-domain-containing-protein	gnl\|CDD\|224575	COG1661, COG1661, Predicted DNA-binding protein with PD1-like DNA-binding motif [General function prediction only].	1.71198e-26
NC_011295.1\|WP_012543803.1\|1275631_1276579_-\|DNA-adenine-methylase	gnl\|CDD\|273146	TIGR00571, DNA_adenine_methylase, DNA adenine methylase (dam). All proteins in this family for which functions are known are DNA-adenine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The DNA adenine methylase (dam) of E. coli and related species is instrumental in distinguishing the newly synthesized strand during DNA replication for methylation-directed mismatch repair. This family includes several phage methylases and a number of different restriction enzyme chromosomal site-specific modification systems. [DNA metabolism, DNA replication, recombination, and repair].	1.90615e-87
NC_011295.1\|WP_143708185.1\|1270520_1272746_-\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|226581	COG4096, HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	4.55334e-91
NC_011295.1\|WP_012544542.1\|1265065_1266193_+\|S8-family-serine-peptidase	gnl\|CDD\|173800	cd07474, Peptidases_S8_subtilisin_Vpr-like, Peptidase S8 family domain in Vpr-like proteins. The maturation of the peptide antibiotic (lantibiotic) subtilin in Bacillus subtilis ATCC 6633 includes posttranslational modifications of the propeptide and proteolytic cleavage of the leader peptide. Vpr was identified as one of the proteases, along with WprA, that are capable of processing subtilin. Asp, Ser, His triadPeptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	3.01187e-13
NC_011295.1\|WP_049750687.1\|1272840_1273224_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|227304	COG4969, PilA, Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion].	5.14497e-09
NC_011295.1\|WP_012544435.1\|1276962_1277226_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.49275e-31
NC_011295.1\|WP_143708131.1\|1277621_1279121_+\|phosphodiester-glycosidase-family-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	5.1782e-36
NC_011295.1\|WP_012543825.1\|1266167_1266584_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	4.54953e-37
NC_011295.1\|WP_012544252.1\|1274709_1275642_-\|type-II-restriction-endonuclease	gnl\|CDD\|377384	pfam04556, DpnII, DpnII restriction endonuclease. Members of this family are type II restriction enzymes (EC:3.1.21.4). They recognize the double-stranded unmethylated sequence GATC and cleave before G-1. http://rebase.neb.com/rebase/enz/DpnII.html.	5.85694e-125
NC_011295.1\|WP_143708133.1\|1281796_1284241_-\|peptidase-M56	gnl\|CDD\|310280	pfam05569, Peptidase_M56, BlaR1 peptidase M56. Production of beta-Lactamase and penicillin-binding protein 2a (which mediate staphylococcal resistance to beta-lactam antibiotics) is regulated by a signal-transducing integral membrane protein and a transcriptional repressor. The signal transducer is a fusion protein with penicillin-binding and zinc metalloprotease domains. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. homologs to this peptidase domain, which corresponds to Merops family M56, are also found in a number of other bacterial genome sequences.	3.22033e-54
NC_011295.1\|WP_012543976.1\|1277235_1277385_-\|hypothetical-protein	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.52817e-17
NC_011295.1\|WP_012544199.1\|1273721_1274705_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	1.94473e-14
NC_011295.1\|WP_012544000.1\|1284243_1284630_-\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	5.18534e-32

>NC_011295.1|WP_012544431.1|1273216_1273417_-|hypothetical-protein
MFVKPLTNNSCSQYDLQFALYPEYVEQLGESFTFADAYKLVQKKLTSEITKEERKVKAGLEQLSHV
>NC_011295.1|WP_049750687.1|1272840_1273224_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MCRINKGFTLIELMLVVAVIVLLVAVVIPMYRDYTERAKQASFCATVHNIETLLYRWRAEKLTDSYPTLDELNTLLTSATYFTTEPINPYTNKSLVITATLTDKEGSISYTKTPTGYILESSPACGR
>NC_011295.1|WP_143708185.1|1270520_1272746_-|DEAD/DEAH-box-helicase-family-protein
MNTEENAKSLIDEHLRALNWNLADFTQITKEYPIPGGERADYAILVNSLPVAIIEAKKQGMDLNAALAQAKNYAKKLNESGKEVFLIFASDGKVFYRQNLKANTRPEKISRLMTYAEIKDFLNPETDILLAGLRNYQKIAVSQVVSAFQLGRDRTYIEMATGTGKTITAAGIISKLYKVGLVRRVLFLVDRDSLAEQTVRSFNKVLGDTFKINRLTGTKEDKYNDISVSTIQFLYVNDKYRAYPNNFFDLVILDECHRSYFGDWHTVIEHFRTGKAKVLGLTATPSDKETQSTDDYFGEPVFRYSYYQGVKDGILAFTERYKFLTNVDLSGIHDMGFDFEPEDLGRRVDVPRRNELIAEKYFEVIGYEQTHTIPKTLVFAASIAHANHLRDALITKYNELNKLPKDSSEAEDFIVVIHNQVRNASELIRKFQEIDSEIRIAVSVDMLSTGIDAPDIEVLVMARPTKSKILYVQMKGRATRKCNEQEHGKTKESFKLIDFVDLAGIEEVVTDETLETDEIIDTTEETEVSSDGEKIPSDKEDGEGKEPKETEKIEMVIADVPVWIVKSEVITSSAFDHIRKQIEPQLKAIKEKTVLKERFVQAVLSWEALNPGIPVDEKYLEAFGFDISTLRDIYGEVTATYKDFIDVALGKTRFKTVEEKNRDAVIAHLKEKKHLNDEQVEFIMMFYDFKKRNPALTFTQFSNSQLLQQKGGIARIKGLFGSLDKFVQLYDEIKAVSFLDV
>NC_011295.1|WP_158300398.1|1267892_1270049_-|restriction-endonuclease-subunit-S
MNKILTLWAEHTNLLFKSLANKNSTVSILLLATSFISWWNLLTREIGEKIYDPAAGTGGFILRAFEVVKSKIDNLVKAGMRVNESTAAYNGVQFDEAEMLYRKLKEESLYAVEKAPDVYKLALMNMILHNDGKSNLFEADSLDNRAQLEHKEKYDVVLTNPPYGPLAQSRVGTFEFHAKRYEALFIQHIMAALRPSEPGKKRSRAVVIILDKILFDNSSVFKNIRMKLLREFDLKAVFSMPAGIFQPYSGVKTTVLYFEKPTKEEWDETKKQNAYTTKQVLFVDVKEDGFTLTTQRRPINGAFQGDDPNIYEPPCGNLPKAVEVFRRWIDWLNNPTKELPDFIDNDFCWTATIEEIKTKDYNLNPGLYRKTIKGKQKWEVVSLREICDIQKGTSITKADTVEGNVPVIAGGQEPAYYHNQSNRDGNIITVSASGAYAGFVNYFDIPIFASDCTTIKSNDEEKALTKYIFYILKSRQEDLYKLQRGAGQPHVYPNDLANIQIPLPPLPVQQELVARLDKQQAIIEQCNAMEKTILEAGIDDSIFEGDWEWVELGELIALRNGISISNTLVSNRGKYPVCGSNGIYGYTDNNDKLLFGETIVVGRVGAYCGNVHYYDVPIWVTDNAIVVTVTNKDKLKTKYLYYFLLSKDLGKYANVTGQPYISQSIISSLKVPLPPIEKQQKIVDFLNVQFETLTNIRRLKENAKQTIKMILDREVFGE
>NC_011295.1|WP_012543490.1|1267197_1267893_-|hypothetical-protein
MHTSVILSEALRYFIDSEHFELSVVLFAVAVERLMKQRLCELDDVLVLDKNNSVEHLVRFKKLQDKVKNIQSRQNLMTRKERRETFLTIPYNEVISRYEAMFNLNIEEDEAVTDKHELKRIREERDRRKAALVRLGNMRNNIVHYFEYYFNPVDEGLFILNEILPFIREMIQEVSDAYKYEDIFNETVFEKLKAKEEELTRQQSDTLSQKIREKKEEYSELNPELIEERKK
>NC_011295.1|WP_158300397.1|1266805_1266943_-|hypothetical-protein
MNGSESKFKRFLNTEEELEAFYSEVVSTVQSDLAQQVYTAHRSTK
>NC_011295.1|WP_012543825.1|1266167_1266584_+|copper-amine-oxidase-N-terminal-domain-containing-protein
MPITPAPLSIIELQIGNPVFKLNNQALLLDSPPVIKNDRTLLPIRAVVEAMGGQVNWNAEERRVDIEYRGKTVTLWIGKNTAKVNGKEVMIDPSNPNVVPEIINGRTMLPLRFVAEALGCEVKWDDATKTITILFPSY
>NC_011295.1|WP_012544542.1|1265065_1266193_+|S8-family-serine-peptidase
MLGYVGYPATFMRYYNMFGGTSCSAPFAGAVATLVKQAHKDWTAEQVRASLMNTASVLYNKVTGEPISVMIQGSGLIDGVAAVKTPALISPYEIDMTATGLHPVVLTVKNVSDATLTFTVTVQPTLGNFEYGQNDGLTLSLTSSRIIVSPRLSATLGLTAKADLSKLTKGSHEALIWFSNGTATLHVPMLIWNDLNTIWWERSNPFDAGYNSKLPPKLINVRATKLPNSSDVAIDFTLNRGSISGSSWGSPEPYWSNYADEIRVDIVNQSGATVATVFDKGHLLIGHYRAVWNGKDSNGQPVPAGEYKYVITVTDYFTNFDIPIIDTDTQYTGYITVGNNATLTPSLTVTASSFAYIPANYQSKNSYSAYHTCTA
>NC_011295.1|WP_012544369.1|1263543_1263750_-|hypothetical-protein
MLLKKGGCRKVVDPEIEAKAGKVFMNPTEEFSKHVPEDEFEWHHLPKFVAMKLNEAGVIVFGKWEREE
>NC_011295.1|WP_012543599.1|1262722_1263145_-|DUF296-domain-containing-protein
MTIKENNGIIAVRLHDGDKFMESLKAVAKDCGVNSAVLHGIGLFKNAELGYFNGHEYVTKSFYQQLMEVISLEGNISMAENGAEVVIHAHCVLGLPDYSLIGGHLMDGTFFNGELFIQKLEGIKLVRRSEPSGLNGLWVE
>NC_011295.1|WP_012544199.1|1273721_1274705_-|methyltransferase-domain-containing-protein
MSLKVKCPICGYKCTKTEYAKHLESYHVEDYQRIVDEINKDIKNGMSIKDVAQKNSLTERFVKGVLGYRTLVKEEMTNYNVSKAKTEIWEPEDFSLETTTVWGFPDRGDWATHSGKYRGNWSPYIPRNVILRYSNENDVVLDQFVGSGTTLVEAKLLGRRGLGVDINPDAVKLALSNVNFEHKCGLADVHIGDARNLDFVKDSSIDLICTHPPYSNIIKYSDNIEGDLSHYDIPEFLKEMYKVASESYRVLKRGRFCAVLMGDTRRKGNIIPLGFRVMEVFCKAGLTLKEIVIKEQHNCTSTGYWKKQSIKYNFLLIAHEYLFIFKK
>NC_011295.1|WP_012544252.1|1274709_1275642_-|type-II-restriction-endonuclease
MKYSNLFYKLISCKDEDDVFEYLIRNLKETIISWDFFVAWEKVINKVEDIEISLNLLNYLVGKENITEKFAELVSKYPEVIDVLPVLVAWRAKNVKVLDPLDDNIFNYKEYSFEKKSSYTTEEIASLTEFADKTGLLAMFKNENIKSVVDYVTGVEVGLDTNARKNRSGAAMEMITELLIKRICAKNRYNYISQATAHKINELFGYEVKVDKSERSFDFAIDNGDKLYLVETNYYGGGGSKLKAVAGEFVTLCRFLKRETPQHTFIWITDGLGWKTAKKPLREAFDEVDYILNLSMLENGVLENIILEGL
>NC_011295.1|WP_012543803.1|1275631_1276579_-|DNA-adenine-methylase
MRKTAFNDVSVTLARPFVKWAGGKAQLLDTFRDYYPRALQTGRVKRYIEPFVGGGAVLFDILQSYNVKEAFVFDINEDLINAYNVVKYCVNELIEILSFLEREYLRADEEERKHMYYDIRNLYNNANKQPGLNVERAAQFIFLNHTCFNGLYRVNKAGLFNVPAGRYKNPKIYDEENLYSVSNVLKKVSIFAADYKASLNYVDKDSFVYIDPPYRPLTATARFTSYSRYDFTDDDQIELAQVFREMNKMGALLMLSNSDPKNVDLNDSFFDELYKDFHIYRVYAKRSINAKADGRASISELIVTNYKVKRGVYEI
>NC_011295.1|WP_012544435.1|1276962_1277226_-|CRISPR-associated-endonuclease-Cas2
MYVIMVYDVGEERVAKVLKTGRKYLTWIQNSVFEGQITESKLEKLKTELKKIIEPEKDSIIFFKLREAYLTKKEIIGREKHDTSNII
>NC_011295.1|WP_012543976.1|1277235_1277385_-|hypothetical-protein
MFDEKLQSTLDYKKIKRNVSYKTLIRLELYKLEKHFMGEDIYRPFVAEW
>NC_011295.1|WP_143708131.1|1277621_1279121_+|phosphodiester-glycosidase-family-protein
MKNSRFRRITVVAICAFLLCTLLGTSTQVINVQAQTSNSPIPIYIQGQKKSFDSLPILRDGRVFLPIRYISEYFGAQVTWNDQTKTVTVKQGSKTISLQIGNSIAQIDGKEVSLDVPAFINGARTYVPLRFIGEAFGRYVDWDQTERAVYIDTDAVSSTMQMSFGGKTFNVKVVKVFLNNPHVDLKIAYGQNQIGLTESLLSMAQRSNAIAAINGTFFRAYETTNPKEPSGNLIIDGRIEHLCFRDKPATTFGFTKDGRADIGLIGMKIEGLYVELAPDMEPWIMDMGWYVGTINRSPQYWSTVGSINLYTPKRGSTTRAYNGGTNVIVRNNTVTQVIHGDNVSIPRDGYVINIYGSEKKYEDRFHVGTVLRYIDNYYVYNGNPDIWQQGVIEGALSAGPHLITDGKITVNPEAENYTIPKITEYSMSRSALGLTKDNKLLMVTVSSAKIEDLATIMQKLGAYNAMNIDGGASSGLYYKGKLLTTPGRDLSNALVVIRK
>NC_011295.1|WP_143708132.1|1279175_1281179_-|hypothetical-protein
MRVIRGLQMPFFVFLAAFVVFLLPASNIYADTAPFFIGGVNIKPYQESNIVLSKENLTITFNKSDDMRNSTASVNAQFIFVNTGDKVSLKVGFPFSLASRPGFDTTSTLESLKVKVKVDGNQITPTFVAPGQQGEYAPLIYFDVTFDKNETKEIQVSYEGKAAGGYFLYVLNTGSYWKGPIGTLDMTFKFPYKAAALNVFSITPGGYKIDGNEVVYHLVNYEPVQNIEVEFLPYYMYEKVNPLRIKAEASDNASDWFNYAMAFFPENPIGSMDEFVGWYRTPGFSDYVESVFKKAVSLQEEGSPEQVVLQEVYSAHYEAPASFAEGLDAVLKLDGNHVSLPSTSLDILRENIGSIENATEGKILGYVMEYAVAADLKQNRPTQALSDFDQLLELADRYFDKDTYYSVSPVLSMAMQNIIGKGMTKYVSPPFTQCFIPSVSLKNQTLTVHYDVPYDLGLALEDFDSNNDQNPPKDYRIVGALEKAPPYGYVVTVTFPKGVTESQFASVKETLTQLGNGAFDVAPDSQTAKLLSSYFGKILDNVMLENGKLAVIKSYVASTPELEMGLADLSLEIRKITSAQQQFKDTPFDEAFGQTMLSYLSSNKAYFDNLPRNSAITFGAVAQTGASGPTSQSLIIAIMASLVAVLLIAFVLVTERRSKVEDANAKE
>NC_011295.1|WP_012544769.1|1281308_1281473_-|hypothetical-protein
MEGYIFAIDGVRVAASGIQLTYDDGNVEILNEDWKVFSKASLGQGAQLMLPKTE
>NC_011295.1|WP_143708133.1|1281796_1284241_-|peptidase-M56
MLETLFQKVLQVSMSTSIVIGVLLLLLPLINRSYSAKWRYLVWLIIAVRLLIPFSPSIAGEAPVTIPSVSQNVQIPIPLPANTNLSEQTNIIPTQPTPVVTPNSSAVRTITLADLLPVIWLIGAILFMTYYFAGYIVFRKSAMRFSEIVEDEQTLATFSQMKQEMGTKGNIELIRSKKVQSPMITGFVKPIFLLPYVEYSEADLELIMKHELIHYKHKDIWNKLVMVVANAVHWFNPLVYVMRYRSNADIEMACDSELVEGTGTEFRKQYSETILSAIHKGRERETVFSTYFYGGVKTMKERLGNIFDGGGKRGGIVALCLVVAAVIVIGALVACGGSTAAELTAEEKAQITELLDNFGRELTNVTIIDPENVVAEQIKEHYTPYLTSNLLSKWVLDPSLAMGRTTSSPWPDRIEVDSMEKVDSDRIKVQGYVVWVASGGQNGLKVTAKVPAVFFVKKDSSTGKFLIDNAFSNKYAFYDTEELTKMLQSVLPEAGSQSEPFIVATWPLIDGSEEEIALAYMGTGGAYVDYYTLCIGQDDKLALANFKDEDGAVGPHVFAEGASVKHEVRLSVYNASPLNFYVYQYQVDRDDSDAISNIDVEAYRWNMDAQVFEFDADASQQFKEELENSLDVDKVILAQLSNALREALVANYSPYYKDIGIHLTLDPRADSFTVKDGVASAILDANITATLKAEKLEDMPFVKGMLDYLESVRSTLTDAQLDAANDVIDDWKSELSGYIGKPEPTSYATYKVVARVDDSGNIDKDTVKFYIEQPSTTGSGFEFYPVPDPMFDSEETLYRNGQNAVKEAIEKAGK
>NC_011295.1|WP_012544000.1|1284243_1284630_-|BlaI/MecI/CopY-family-transcriptional-regulator
MKKSIRRLPDSELEIMKIIWDAKEPVTSAYISEKLKGKKDWKITSILTFLARLTEKGFIECKREGKVNIYRPLISEQEYLEKESKSILEKLYNNSLTNFVASLYNSNAIAEDELKELQEFIEELTRGE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

192483 : 199927

Cyanophage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012544073.1\|192483_192969_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.7e-25	47.0
WP_012544565.1\|192992_193703_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4SM18	Cyanophage	5.8e-45	42.9
WP_012543900.1\|193704_193956_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_012544456.1\|193961_194639_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_012543661.1\|194645_196862_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	3.6e-165	44.5
WP_041735524.1\|196840_198253_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	9.8e-60	34.9
WP_012544489.1\|198266_199283_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SQF5	Cyanophage	4.4e-70	47.6
WP_012544901.1\|199279_199927_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.4e-21	36.0

DBSCAN-SWA_2

573392 : 583847

Bacillus_virus(33.33%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012543945.1\|573392_575306_+	DNA topoisomerase (ATP-hydrolyzing) subunit B	G3M9Z3	Bacillus_virus	1.5e-143	44.5
WP_012544627.1\|575320_577597_+	DNA topoisomerase 4 subunit A	G3M9Z5	Bacillus_virus	8.0e-96	36.9
WP_012543707.1\|577616_578000_+	archease	NA	NA	NA	NA
WP_012544432.1\|578042_579476_+	RtcB family protein	A2RQD0	Archaeal_BJ1_virus	4.9e-115	46.2
WP_012543618.1\|579472_579889_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	NA	NA	NA	NA
WP_012544264.1\|579861_580419_+\|protease	glycoprotease family	NA	NA	NA	NA
WP_012543717.1\|580409_580883_+	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_012544378.1\|580898_581849_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	1.6e-37	34.9
WP_012543612.1\|581919_582216_+	co-chaperone GroES	A0A221S322	uncultured_virus	3.5e-20	50.0
WP_012544191.1\|582233_583847_+	chaperonin GroEL	A0A219YK78	uncultured_virus	4.1e-155	56.1

DBSCAN-SWA_3

858644 : 865959

Streptococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012544182.1\|858644_859616_+	D-3-phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	9.2e-09	22.5
WP_041735717.1\|859605_860958_+	DUF814 domain-containing protein	A0A0N7HVQ3	Ostreococcus_lucimarinus_virus	5.4e-07	33.6
WP_012543534.1\|860950_862084_-	S41 family peptidase	A0A0R6PIZ1	Moraxella_phage	5.0e-22	29.8
WP_012544429.1\|862092_863253_-	peptidoglycan DD-metalloendopeptidase family protein	Q9AYV6	Lactococcus_phage	3.7e-20	44.8
WP_012543782.1\|863236_864166_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_012544608.1\|864137_864854_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	9.4e-35	37.3
WP_012543910.1\|864846_865959_-	peptide chain release factor 2	A0A2I2MPK0	Mycobacterium_phage	5.2e-08	49.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_011295

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection