CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_011653	Thermosipho africanus TCF52B, complete sequence	12 crisprs	cas14j,cas3,cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7,cas6,csx1,cas2,cas1,cas4,DEDDh,csa3,cas3HD,cas5,cas7,cas8b1,casR,cas7b	0	11	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_011653_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011653_1

309784-310512

TypeIII

Consensus_repeat	Method
GTTTAGAATCTACCTATGAGGAATGAAAAC	PILER-CR
GTTTAGAATCTACCTATGAGGAATGAAAAC	CRISPRCasFinder
GTTTAGAATCTACCTATGAGGAATGAAAAC	CRT

10 spacers

cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7,cas6,csx1

The CRISPR arrays of NC_011653_1

>merge|NC_011653|1|309784-310512|PILER-CR,CRISPRCasFinder,CRT
GTTTAGAATCTACCTATGAGGAATGAAAACCATATTTTTTAGATAAAATATCACGCATTAAGTCCCCCAGTTTAGAATCTACCTATGAGGAATGAAAACTTGAATTCCTCGACACCCTCCTTTAAGATTTTCATTTGTTTAGAATCTACCTATGAGGAATGAAAACTATACTTCTCTATGTTGTCATTATAGTTATAGCAATATCTCGTGGTTTAGAATCTACCTATGAGGAATGAAAACATTCAAATTCTTTCTTTAACATAATAACACCTCCATACATTTGTTTAGAATCTACCTATGAGGAATGAAAACCTTAATTCTCAGCTTCGTGTTATATATTTCAATTTTCTTTTCCATAAGTTTAGAATCTACCTATGAGGAATGAAAACATAATAGGAGTAATAATATTAATCTCAAAATCTGGTTTAGAATCTACCTATGAGGAATGAAAACTGTATAATGTAATTTCCTTTTTTAAAAACATAATTTCCGTTTAGAATCTACCTATGAGGAATGAAAACGCTTTTCGATGAACTTTTCGAGTTGTTCGTAGCTGTGTATAATCGTTTAGAATCTACCTATGAGGAATGAAAACCAATCACATCATAAATTTCACCATGGGTCTTAATTACTGTTTAGAATCTACCTATGAGGAATGAAAACTCGATTACTTCTTTAATTAAGTTGTCAAGTTCGCCGTTTAGAATCTACCTATGAGGAATGAAAACT

>NC_011653|1|1|309784-310446|PILER-CR
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATATTTTTTAGATAAAATATCACGCATTAAGTCCCCCA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTGAATTCCTCGACACCCTCCTTTAAGATTTTCATTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TATACTTCTCTATGTTGTCATTATAGTTATAGCAATATCTCGTG
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATTCAAATTCTTTCTTTAACATAATAACACCTCCATACATTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTTAATTCTCAGCTTCGTGTTATATATTTCAATTTTCTTTTCCATAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATAATAGGAGTAATAATATTAATCTCAAAATCTG
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGTATAATGTAATTTCCTTTTTTAAAAACATAATTTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GCTTTTCGATGAACTTTTCGAGTTGTTCGTAGCTGTGTATAATC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CAATCACATCATAAATTTCACCATGGGTCTTAATTACT
GTTTAGAATCTACCTATGAGGAATGAAAAC

>NC_011653|1|1|309784-310512|CRISPRCasFinder
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATATTTTTTAGATAAAATATCACGCATTAAGTCCCCCA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTGAATTCCTCGACACCCTCCTTTAAGATTTTCATTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TATACTTCTCTATGTTGTCATTATAGTTATAGCAATATCTCGTG
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATTCAAATTCTTTCTTTAACATAATAACACCTCCATACATTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTTAATTCTCAGCTTCGTGTTATATATTTCAATTTTCTTTTCCATAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATAATAGGAGTAATAATATTAATCTCAAAATCTG
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGTATAATGTAATTTCCTTTTTTAAAAACATAATTTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GCTTTTCGATGAACTTTTCGAGTTGTTCGTAGCTGTGTATAATC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CAATCACATCATAAATTTCACCATGGGTCTTAATTACT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCGATTACTTCTTTAATTAAGTTGTCAAGTTCGCC
GTTTAGAATCTACCTATGAGGAATGAAAACT

>NC_011653|1|1|309784-310511|CRT
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATATTTTTTAGATAAAATATCACGCATTAAGTCCCCCA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTGAATTCCTCGACACCCTCCTTTAAGATTTTCATTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TATACTTCTCTATGTTGTCATTATAGTTATAGCAATATCTCGTG
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATTCAAATTCTTTCTTTAACATAATAACACCTCCATACATTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTTAATTCTCAGCTTCGTGTTATATATTTCAATTTTCTTTTCCATAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATAATAGGAGTAATAATATTAATCTCAAAATCTG
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGTATAATGTAATTTCCTTTTTTAAAAACATAATTTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GCTTTTCGATGAACTTTTCGAGTTGTTCGTAGCTGTGTATAATC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CAATCACATCATAAATTTCACCATGGGTCTTAATTACT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCGATTACTTCTTTAATTAAGTTGTCAAGTTCGCC
GTTTAGAATCTACCTATGAGGAATGAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011653.1\|WP_041427171.1\|302426_303659_-\|glycerate-kinase	unknown	unknown	gnl\|CDD\|225254
NC_011653.1\|WP_012579490.1\|313492_314377_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl\|CDD\|274210
NC_011653.1\|WP_012579492.1\|315435_317919_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
NC_011653.1\|WP_012579487.1\|308659_309166_-\|transcription-repressor-NadR	unknown	unknown	gnl\|CDD\|224740
NC_011653.1\|WP_012579485.1\|304495_305635_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|184603
NC_011653.1\|WP_004103905.1\|301462_302422_-\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240642
NC_011653.1\|WP_012579493.1\|317936_319157_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl\|CDD\|224286
NC_011653.1\|WP_041427172.1\|303639_304515_-\|NAD(+)-synthase	unknown	unknown	gnl\|CDD\|223249
NC_011653.1\|WP_012579489.1\|313092_313503_-\|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	gnl\|CDD\|378242
NC_011653.1\|WP_012579495.1\|319913_321350_-\|TIGR01897-family-CRISPR-associated-protein	csx1	cd09728_csx1_CAS-III	gnl\|CDD\|187859
NC_011653.1\|WP_012579481.1\|298705_300346_-\|methionine-synthase	unknown	unknown	gnl\|CDD\|376761
NC_011653.1\|WP_148203261.1\|321354_322446_-\|SAVED-domain-containing-protein	unknown	unknown	gnl\|CDD\|380122
NC_011653.1\|WP_012579494.1\|319180_319903_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NC_011653.1\|WP_012579488.1\|312328_313075_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	gnl\|CDD\|213662
NC_011653.1\|WP_012579497.1\|322793_323558_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012579486.1\|307394_308663_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340874
NC_011653.1\|WP_012579482.1\|300347_301427_-\|NAD/NADP-octopine/nopaline-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|376763
NC_011653.1\|WP_004103915.1\|306245_307283_-\|heat-inducible-transcription-repressor-HrcA	unknown	unknown	gnl\|CDD\|273017
NC_011653.1\|WP_012579491.1\|314390_315443_-\|type-III-B-CRISPR-module-associated-protein-Cmr3	cmr3gr5	pfam09700_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
NC_011653.1\|WP_004103913.1\|305640_306231_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|366423

Protein	Function_ID	Function_description	E-value
NC_011653.1\|WP_041427171.1\|302426_303659_-\|glycerate-kinase	gnl\|CDD\|225254	COG2379, GckA, Putative glycerate kinase [Carbohydrate transport and metabolism].	1.10149e-145
NC_011653.1\|WP_012579490.1\|313492_314377_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	1.71055e-63
NC_011653.1\|WP_012579492.1\|315435_317919_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	1.16474e-111
NC_011653.1\|WP_012579487.1\|308659_309166_-\|transcription-repressor-NadR	gnl\|CDD\|224740	COG1827, COG1827, Predicted small molecule binding protein (contains 3H domain) [General function prediction only].	3.60254e-43
NC_011653.1\|WP_012579485.1\|304495_305635_-\|molecular-chaperone-DnaJ	gnl\|CDD\|184603	PRK14282, PRK14282, chaperone protein DnaJ; Provisional.	0
NC_011653.1\|WP_004103905.1\|301462_302422_-\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240642	cd12165, 2-Hacid_dh_6, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	6.39767e-130
NC_011653.1\|WP_012579493.1\|317936_319157_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	gnl\|CDD\|224286	COG1367, COG1367, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.54072e-14
NC_011653.1\|WP_041427172.1\|303639_304515_-\|NAD(+)-synthase	gnl\|CDD\|223249	COG0171, NadE, NAD synthase [Coenzyme metabolism].	4.0484e-71
NC_011653.1\|WP_012579489.1\|313092_313503_-\|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	2.54842e-15
NC_011653.1\|WP_012579495.1\|319913_321350_-\|TIGR01897-family-CRISPR-associated-protein	gnl\|CDD\|187859	cd09728, Csx1_III-U, CRISPR/Cas system-associated protein Csx1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; Some proteins could have an additional fusion with RecB-family nuclease domain; Core domain appears to have a Rossmann-like fold; loosely associated with CRISPR/Cas systems; also known as DxTHG family.	9.42446e-30
NC_011653.1\|WP_012579481.1\|298705_300346_-\|methionine-synthase	gnl\|CDD\|376761	pfam02310, B12-binding, B12 binding domain. This domain binds to B12 (adenosylcobamide), it is found in several enzymes, such as glutamate mutase, methionine synthase, and methylmalonyl-CoA mutase. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, which is important for B12 binding.	3.57837e-08
NC_011653.1\|WP_148203261.1\|321354_322446_-\|SAVED-domain-containing-protein	gnl\|CDD\|380122	pfam18145, SAVED, SMODS-associated and fused to various effectors sensor domain. Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. The sensing of ligands by SAVED is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.	1.72652e-10
NC_011653.1\|WP_012579494.1\|319180_319903_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.14095e-33
NC_011653.1\|WP_012579488.1\|312328_313075_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl\|CDD\|213662	TIGR01898, repair_system, CRISPR type III-B/RAMP module RAMP protein Cmr6. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1791 of Thermotoga maritima, is designated Cmr6 [sic], for CRISPR/Cas Ramp Module protein 6. This family is both closely related to and frequently encoded next to the TM1792 family of Cas proteins described by TIGR01867. The two proteins are fused in an example from Methanopyrus kandleri.	2.19934e-38
NC_011653.1\|WP_012579486.1\|307394_308663_-\|MFS-transporter	gnl\|CDD\|340874	cd17316, MFS_SV2_like, Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily. This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.6815e-50
NC_011653.1\|WP_012579482.1\|300347_301427_-\|NAD/NADP-octopine/nopaline-dehydrogenase-family-protein	gnl\|CDD\|376763	pfam02317, Octopine_DH, NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain. This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. The Pfam family consists mainly of octopine and nopaline dehydrogenases from Ti plasmids.	1.67494e-58
NC_011653.1\|WP_004103915.1\|306245_307283_-\|heat-inducible-transcription-repressor-HrcA	gnl\|CDD\|273017	TIGR00331, Heat-inducible_transcription_repressor_HrcA, heat shock gene repressor HrcA. HrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures. In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene. [Regulatory functions, DNA interactions].	1.62401e-58
NC_011653.1\|WP_012579491.1\|314390_315443_-\|type-III-B-CRISPR-module-associated-protein-Cmr3	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	4.51808e-53
NC_011653.1\|WP_004103913.1\|305640_306231_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|366423	pfam01025, GrpE, GrpE.	4.44808e-35

>NC_011653.1|WP_012579487.1|308659_309166_-|transcription-repressor-NadR
MKERLKKILSILENSNKPVKGRDLAEVLKVSRQVIVQDISVLKTKGYKIYSTREGYILEKKRDVVRKMIAVKHSEDEIYDELLKIVKAGGKVIDVIVEHPLYGEIKGRLDIETMDDISKFMALMESSNATPLLKLSGGVHIHTIEAPNKKIMNDVLDAISKYLLGVEK
>NC_011653.1|WP_012579486.1|307394_308663_-|MFS-transporter
MKIDQVVDLIVSKKEQKNLLILTSILWIIGSAGVMVMPFVVPDLVSEWNLTTVQASSLISSVFIGMLLGALFSGIILDYFGRKIGVIFYLLVTVIFTVLFGFSKSFGSAYVFRLLSGFGYGGLLPSVNTYLSEYTSIRLRGRYLVILEASWAVGSILIALFAVTLGEKLGWRWDFYIFSIGIISLIPFFRKKDTPKYIFEKRGVEGLKKIFNKVPENIEEIEKVKVTFSGLFRKEHIKQTILVIISWFVVSFVYYALFSWAPKIFIASLGITITKAKWYTFFVYLAQLPGYLSVAYLIEKWGRKKTLATYFIGMGLSSFLLLLATGNLSFLFIVLILSFFTLGVWGLVYAYTPELFPTSFRGTANGVAGATARIAGIIAPYFTGYFVDKSIVAALSFVSLFAIFAAVMTLVLGVETKDKAVN
>NC_011653.1|WP_004103915.1|306245_307283_-|heat-inducible-transcription-repressor-HrcA
MADKWGEKMKELSTRQEQILYCLVREYVKSGTPVSSQKILESTNLEWSGATVRNDMRKLDYLGYVFQPHTSAGRVPTDKGLRFYVNEILKLRKETKKSGSSIDVSIDFPIGDLDKIIQGAAKLLATTVKAFVIIEKPNPMYLRIRRVVLTPVTKNFSIVNIITELGLTSVLPIQHSEIYNIQEIEEFLNKSLDGILLSEFRAKLREVVERFSWVGGRLKEFIELSEKIASEKYEEYITEGVFNLVNAKRFDEEKLKEIVRFSTNEEYYSKIFELGEGIFIGKEHNIKNFEQYSILIMPYFVFNREVGKIAVIFDKFSDYNRVFDSVEYVVNRLTEYFTVVARNVE
>NC_011653.1|WP_004103913.1|305640_306231_-|nucleotide-exchange-factor-GrpE
MEKKEMKKEKMIENEKVENVKEDANKEKKEKGKEKDLEKIIDEQSKKIEELENQLKEFENYARILKSQFENYKKDVAREKEQISISTIGRIVEKLVPIIDDFKRAFKNVDDETKKTQFFKGMEIIYKNLFKILEGLGLQEIKVGDKFDPFEHEAVERVEDEEKEEYSIVEIVEDGYKFNGRVLKPVKVKVSIKPRR
>NC_011653.1|WP_012579485.1|304495_305635_-|molecular-chaperone-DnaJ
MAKKDYYEILGVSRNASQEEIRQAYKQLIKKWHPDRNHQNRKEAEEKFKEIQEAYEVLSDPEKRAMYDRFGYVGDVPPNAGSGGGFGGFGGFGGFEDIFKDFGDFINNDIFNIFFGDQRTSSRQKQRRAKRGEDINITVDVPFEQVFTGTTIPIEYDRYEVCSHCNGEGVEPGSGWVSCPKCHGTGVVREERRTFLGVIVNQYTCNQCGGTGKIPGETCHVCGGSGRIRKRHRVEVKIPAGVDNGTVIRVQGKGNAGYNGGGYGDLYVNVRITGHIDFERRGNDLIKEIKIDYVEAILGTKVKIKMPDGRVKEVKIPSGVQDGENIYVYGEGVPDMRTGRRGDLILKIKVDIPKRVSRSEKKLLKEIAKLRGKDVDEEE
>NC_011653.1|WP_041427172.1|303639_304515_-|NAD(+)-synthase
MLTKKSEKIVNFLRETVAQYNFRGLVLGVSGGLDSAVVLALLVKAFDRDKIKCFILPERDSPKDSVKDAVFVCKYFGVEYEIKNITKILRALGIYKYYPPAFFVPWKVKENFAKKRWQKYKEKGNPFEFDIEGIEDEEFLKGISYYRAKHRVRMVYLYKEAERRNYAVVGTTNKTEFLTGLYVKWGDDSTDIEPILHLYKTQVYELAKELNVPEKIIMKPASPDLIPGIGDEEIFGLDYSTLDRILDKLLNNKSLDGEDPEKVKLVKRLYQIGKKRNSLRNVSMVDDLYGT
>NC_011653.1|WP_041427171.1|302426_303659_-|glycerate-kinase
MIYMELKTLAKKIIFDTLEDIQPEKLVKEKLKEIRVDKKVYVLSIGKAAWKMAKAASDVLDIEYGIVITKYGYNFGNIENFDIFEAGHPLPDENSLSATKFAVEKFSKLSKDDILLFLISGGGSSTFELLQDGLSLDDLKDVTTQLLKSGADIKEINTIRSRLSKVKGGRFLNFVKSKVITLVLSDVLENDLRYIASGPTYEACSTFEDAYKIIKKYNLDFNENIINVLKKDVKINKQIDVEHYIIGSIDIACDILEKHARKYNLNTLVLTTRLDCEAKEAGKFIASIAKSSKLKTPYCIIFGGETVVKVKGSGKGGRNQELCYSAALEIENMKDVVIASVGTDGTDGPTDAAGAIVDGKTISKVRKFSNDPNEFLLNNDTYNALKLSGDLLITGPTGTNLNDIGFILKG
>NC_011653.1|WP_004103905.1|301462_302422_-|2-hydroxyacid-dehydrogenase
MKALVLTKITDYFRKKMEEFNEIEWYTPKDIDYVLEDVEIIVTGYLTEEQVDKAKKLKAIFIPWTGADKLPWKKIKERNIIVSNSHGNGKMVAERALSLSLALLGRIIEFHNDLEKGIWHGFAVGFKEDDYWYSLQGKNVAILGTGVIGRHLAKLLKGFDCHITGFKRSKEQIAGFDRIVTSIEEAISDAQVIYLALPLTEKTYKIIDEKMFEKMRGKFLINVGRGELIDEYSLFKALNENILRGFASDVWYKYPSKDEQVILPFNFPIHKFKNVVLSPHVGGFTIEGQQGRIDELFENIESFLKKGFPKTAVDPELMY
>NC_011653.1|WP_012579482.1|300347_301427_-|NAD/NADP-octopine/nopaline-dehydrogenase-family-protein
MNITVIGAGNGGLALAGFLAMRGFAVTLYNRSLKRISSFIKSRVIKLEGEITGSVKIKNVTNNLEEALKDAELVMIVVPAFAHADIAEKVSKYVKDGQIFILNPGRTFGALEFYNIFKKNRVDKDVIIAETQTFLFASRTSNPGVSHIFRVKNAVPISAIPSTKNEKLKKVIEDIVPEFQVVDSIIYTSFNNIGAVFHPATLILNSGRVESTFGKFEFYLEGITPSVARVLEKIDAERCSVARTLGIEPMTAKDWLNYAYDVLGNNLYEAIHNNAGYQGIIAPPSLQNRYIFEDVPMSLVPISEMAKKLGINTPAIDSIIYLSSIMMGRDFYREGRTLERLGISKLSLDEIKNLIYKGV
>NC_011653.1|WP_012579481.1|298705_300346_-|methionine-synthase
MVKKILGGSIGSCVHVAGVLNFLKLAEKEGYKSIYLGGAVPLEKFVGAIVESDPDIVAISYRLDPKALEKLLNEFYKMIKEKNLLDKVYIFGGTVETAAVARKFEFISKIFDGSQDIDEVILWLRNAKKDKEKKEIPPQFLPERIIYKRPYPLIRHHIGLASLEETEKHIRILAESGLLDIISLAPDQNCQQYFFEPEKMDRKQDGAGGAPIRTKEDFIRLYNASRTGNYPLMRCYSGTSNLVEFSKLLKETINNAWAAIPLTWYSDLDRRSDRPLLEAIKENQEAIKWNAENNVPVEINEAHQWSLRYAHNAIEVATFYLAAYNAKKLGVRHYVAQYMLSTPPGLSPKFDLAKQIAKKQLIETLEDETFTSYTMIRTGLLSFPADEHSAMGQLVSTMFYGMYLKPDIIHVVSYSEAIRRATSKEIIESVKMVKQAMRNAMNGLPDFLEDKSIRNRVEVLKNEAMMIIDAIKQIGKGFDDPLIEPEVIYNAVKLGILDAPGLKGMSVAKGRFETQIIDGACYAVDENGKILTEEKRLEIIRKEAGM
>NC_011653.1|WP_012579488.1|312328_313075_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MKVGYKEDLGNKNIKSFSLFYDKYVYYNLHKNLSEKKNEDKLKDLDNLLKVFFNNNIYIYENSKILNDVFSKALKQLETSGYQIYEKSFELSSPLLIGSGIPSAYEVGIYLNRNYGLPVIPGQSIKGSFKAFLDEIDENDLIFFGNNENSSEIFFFDAVPEKYKLGIDILNPHFKEYYLSENVPNDVYQPVPINFISVFEGTYVFRYVIVSEKNDDNKNKKISEYFEEFLTIYGIGAKTSMGYGRFKK
>NC_011653.1|WP_012579489.1|313092_313503_-|type-III-B-CRISPR-module-associated-protein-Cmr5
MRNKIEIKNFSQNKIKENLKEMESNDELKKSYKSLVKSLGALVLQNGLYASIVFIISKTKDKNNYYYVLKDIQKFLKEYFKDSYVVNNKDIKDIKQEVLEFLESESFKKAYKQFSEQFIEFIKWHRRYVDIYIDID
>NC_011653.1|WP_012579490.1|313492_314377_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MNHEVGRIGFFYAVTQIHAGKGFDVGIVDQPIQREIHTRFPVINGVKGAIRNEISRLININYNDITQIFGTEFQDNEASEAGKVSFSEGKLAFYPVRSIDRGIVWITCPLILSRLKIAFDVVGLEEFKKLIEKINISYKEDYKALSTINDSKICLEEFEQDIKYSKDLMSFVNHLRNIFPDERLFERFSSNLVILSDKDFSYFVTNSTEVIARIRINPQKRTVDKGALWYEEYIPQDSVLFFISKLLVNNADYLLKKIDELNSKFLNIGGNASIGKGIVYISFLPFKGEDKNEK
>NC_011653.1|WP_012579491.1|314390_315443_-|type-III-B-CRISPR-module-associated-protein-Cmr3
MSKVKVLKFIPIDWVSFRKSKNFSTFENTIFPNIKTFYGAIFSAYFRKRGTKNAIKEIEKMIEEKLINLIGPFIVSERNEIYFRKPANLKLRKICKNENSCEYEYEYYKGFPCQDSFAVDDKNLRYIKYSNIDNLSEEGITFISISDLETFKKSSDKKLYLNLHKYNKNLPFSIERKVGIALDNKKRMVDKEHGAFYLLSTYRFRDGAGFGVFIDEKTEQFLNENKINTVNIGSKGKLARLEIFEIETDLFSKESSSKIKGLMLLTPAVFKNGFLPTSEYIRQKIVAVCNYKPEVYSGWDLKKNKPGKMFRIVPPGSVFFTEEKYLENLELTEEFNEYNYGKFIVLENCE
>NC_011653.1|WP_012579492.1|315435_317919_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MNEINWKKKVEAFLHDPVNKMANIRGHKNLAKTLLNKVGLKQNNNPRYDYIASAATRILFPQEVTKIKRNSEQIRIEFDESKFFHPFSGNDLSEYHKVKEKIKNIDEENFISKLAKIEDYKKLAYRLWWEIPKISDYSYLILEDTRLTNQSIIDHLDISSAFATADEESNGYLILSVSIGPVQEFIAAGRKIRDLRSGSYLLSYLTFKGIQVIGEKFGFDCIIFPDLRNNYLVKKYLENIDDFFKNNSEKFLMQPEVASLPNVFTAIIPYKEEYIDKNSEENIEILIKSAIKKEIDNISKFIFDLIKNKKLKEYTFSKEIENNPELYWNRQVNIFPDIIVESVMFYIFGDEKLNKENWIFKEWEKFIGSNELENYYEQLSKLENTYSLSEANMYNYHTKILQAKSFLRKNTRNFKALIEDFETPGDDLSGGLKSLVIYEKGDRKENLSALSVIKREFYRYLKNVGLDEAGEGIRNTRPISYEDSEDDEENNKESIVKEYKLGVLLMDGDQMGKWITGDKIEDNLKNVHPKAKEFLEKQSSDYLDFLKKYKLINPTYQKSISRTLNKFSYFVPHIVREFEGELIYAGGDDVLAIFPANRVLEAANKIRKVYSGIGNVRVEVNKNDGKSEIYEFRNGFCYKDDLPLFNMMGEKATMSAGIVVCNPKLNLSLVLDEVRKAEKEAKNEGRNRFSLRTIRRSGKITNLVFEWEYLSKSKEVFDILDEVEFVYSLFEKNETKKEKSYNSFFRRLKVEYEKLEISKKEFIEQVIPYVLKRIKKIKGIEKVIEVLEKYVQILEENSKNFENNNLEKFIDLLLEYEYIKRKVDKYE
>NC_011653.1|WP_012579493.1|317936_319157_-|type-III-B-CRISPR-module-RAMP-protein-Cmr1
MKNLETLKFNIEFISPLINRRGKYKDSILLPQTVRGVMRYYFRATAARVFGNNYKKIKELEDIIFGSINNKSFFDVTVTLQKERKIKLSELKALRYPLYGVIFTKKNEIKFNEKISLLDSRSEFLVNFIFFKSFFKRKIKDCNKVDEYFHKFKEFIKDLFVLISLVGGFGAKVKKGFGQFVIRNIERDIKLEDIGTILKNLEEKIKYLDKIFIKENEKNKESITNNSSSISNEAFDFPAFVDGFFYVYKLKKEFYSYENALRNIYFSKKNNFSYLNLKKKLRGSAFKDAIQNFNDKKKVDFNDALLGLPVLFFYGKANYKLNALDDKGNEYRKSSLLTIKLWRERNGKYKVYLIVLLSKIHLKNSKIVLKKIVQTNGSEGKSINIDFDYNKLKNTIEKYKELNKII
>NC_011653.1|WP_012579494.1|319180_319903_-|CRISPR-associated-endoribonuclease-Cas6
MRIYLDLDFEKLELPIHYNHILQSIIINMIDSSGYRKFIHDEGYVLGKRKFKLYTFSRLLGKFQIFGNKIAFFNGARLIISSLDDAMVEYIINYILKKGYINVLGEKIYVKAAVLKSLPSANYLRVSTKSPVVVYSTLFNYENKKETIFYEPDSSKFLSLVYENILKKYTAFYGSISKNNIEIKHVGKNPKRVKVVYKNTVIFGWLTAFDIYGDFELLKVAYDAGIGMKNSMGFGCVELI
>NC_011653.1|WP_012579495.1|319913_321350_-|TIGR01897-family-CRISPR-associated-protein
MKLFFSTFGKISNYKEVEYSIDYNENTFESPFLPDLMCKAFGVDTTELFLLDTLVEKNDLLKEDFKYEDIITSLENKYFNYFKSKDYKGNLNLHIIPGVGSYKEFRFVGNMNDTYYMTLIQLLNIFSRPEVINSEEIEVILDISFGINYQSNVLYRTLMDILPVLAYFKKVRFKLTNAEPVINTSAEGKNKINVYVVEEKVFEQSISYKKDFAKKTISVFRGLSINERKEVGKNYIREFEKRLRNEKNMGLNNVFLNLELYLKSIYYGLPLLYLYAMNGADFKYVVDKSLEMYNSAIEIRDSNENLKMVLRKLEFSEGIKYLVLGSIFKIYFENIYGTKYCTEIPYDELKKLSNFIWKIDEFKNQISLVLEKEIKEIESLFDYIEEGEEILFDLEMLKSRKNESIECEEKVDENTKKELEHENDELKKQNSIENFSRKERNFIAHGSLSKNTFYLKKYNSMVCIRLNEEEICKLGKAI
>NC_011653.1|WP_148203261.1|321354_322446_-|SAVED-domain-containing-protein
MKSSLEKIESLVGKKLIVIFDSEFKGNSFELAVAIGSLCKKIPKNIAFTGEIDEKGNIKRNIEYLDLKMKICSENNLKLISAFDVDNLFELKEFFEAKKIHIPILISLMAKDKEYIRTSYEELKEAVNEKFEIKYSDIFEKIYDVNKVFVKDSLNDDWGQVLKEVNSLLYKIISNRGIPHIAIMGPASFSMALGIALGVQNPLVVYHKAGIEYKPVIDLTDNVRKVKNIVSDYKFVKYSVENENGKNCAFILYFASHNPYDAVKNFLSKNNIDSKLVLIEPNFGKGNLPAEDWSEIVSEIMSVTQNIQFKHSCENVFFFMSCPVPLAFGVGLSFGDFAKGSIFHFDKNTGDYIEVFKIEKIRG
>NC_011653.1|WP_012579497.1|322793_323558_-|hypothetical-protein
MSFLKKEFELYKNLFGKYKLNIESLKIVPEGKALEAGDVFVIYGDILVYGVVIEKNGDLAECVLLSQDVFLSSSKALKIKINHLVDYVYVTHVNFYIEDNFAKNYCQVIINVKEDINKIAENVEELEEQIYTGPRKEYFDLLIDQISLLYDIFFEKIFDETKEEDKIIEINIPYASEFALVAGTNSLRGENFVGIVENNTLKVYLQDNAIGKKGKLIFKNQVIYEGELPNAFVSNNIKVSVEDLKKFLVIEVID

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Crispr_ID: NC_011653_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011653_2

310521-311880

TypeIII

Consensus_repeat	Method
GTTTAGAATCTACCTATGAGGAATGAAAAC	CRT
GTTTAGAATCTACCTATGAGGAATGAAAAC	PILER-CR
GTTTAGAATCTACCTATGAGGAATGAAAAC	CRISPRCasFinder

19 spacers

cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7,cas6,csx1

The CRISPR arrays of NC_011653_2

>merge|NC_011653|2|310521-311880|CRT,PILER-CR,CRISPRCasFinder
GTTTAGAATCTACCTATGAGGAATGAAAACATCCCGATGTCCCGGTCTTCTCTACTATCTTGTATGGATTTTGTTTAGAATCTACCTATGAGGAATGAAAACTTCATTTTTGTATTATACATTTCAATTTCCTTTTTTAAGTTTAGAATCTACCTATGAGGAATGAAAACATCACAGAATAATCTGTTGTCGATCGCCACTATTTTAAATCGTTTAGAATCTACCTATGAGGAATGAAAACGTGAATAAGTGTTTCTTCAAACTTTTCAAGACTAATGGTTTCGTTTAGAATCTACCTATGAGGAATGAAAACCAAAAATGGCACTTGCAACACTTTCTCCTTTTAGTTTCCTCAGTTTAGAATCTACCTATGAGGAATGAAAACCGCGTTTGCCGTACTCGTCTTTGTATACACCTAATCTATAAGTTTAGAATCTACCTATGAGGAATGAAAACTGACTTCAGGTTCAAAGGCTTCCATTAAATCGTATATAATTGTTTAGAATCTACCTATGAGGAATGAAAACGTACCTCCACAAGTGCACCATTCTCAATCTTGAAACTCCTCGTTTAGAATCTACCTATGAGGAATGAAAACAACTTTTGGAATGTTACGTTGTATGGGACTGATAAAGGTTTAGAATCTACCTATGAGGAATGAAAACCTCCCTTCATCAACTAAGTAAAAATAATTATCATTATCTAAAGTTTAGAATCTACCTATGAGGAATGAAAACCATGATTTCGAAGTTTCAAAGTACCGCCTTCAAACCCAAAGTTTAGAATCTACCTATGAGGAATGAAAACACGTATGTACATAGAAGATGAGTTTATAGAAACAGTGTTTAGAATCTACCTATGAGGAATGAAAACTTTTTGACGATTCCTCTAGCATTTTGTTGAATTCTTCGTTTAGAATCTACCTATGAGGAATGAAAACCCGTCGTAAAAAAATCATCTGCTTTTACTACTTTTACACCATGGTTTAGAATCTACCTATGAGGAATGAAAACACAAATTCATATGTATCCATAATTACACCTTCACTTAGTTTAGAATCTACCTATGAGGAATGAAAACATGTTTCCGGCACTGGCTCTATGAGTCAACTAGGAAACGTTTAGAATCTACCTATGAGGAATGAAAACGGACTAGTTACTGCTCCTTGTGGCAAACGTCCTTTATATGGTTTAGAATCTACCTATGAGGAATGAAAACGATTCTAAAACATAGTCGCTTTTTGTTGAACCAAAGAAATCGTGTTTAGAATCTACCTATGAGGAATGAAAACGTACGAAACTGTCTCCAATTTGCAACGGGGATAATTGTTGTTTAGAATCTACCTATGAGGAATGAAATT

>NC_011653|2|2|310521-311880|CRT
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATCCCGATGTCCCGGTCTTCTCTACTATCTTGTATGGATTTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTCATTTTTGTATTATACATTTCAATTTCCTTTTTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATCACAGAATAATCTGTTGTCGATCGCCACTATTTTAAATC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTGAATAAGTGTTTCTTCAAACTTTTCAAGACTAATGGTTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CAAAAATGGCACTTGCAACACTTTCTCCTTTTAGTTTCCTCA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CGCGTTTGCCGTACTCGTCTTTGTATACACCTAATCTATAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGACTTCAGGTTCAAAGGCTTCCATTAAATCGTATATAATT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTACCTCCACAAGTGCACCATTCTCAATCTTGAAACTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AACTTTTGGAATGTTACGTTGTATGGGACTGATAAAG
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTCCCTTCATCAACTAAGTAAAAATAATTATCATTATCTAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATGATTTCGAAGTTTCAAAGTACCGCCTTCAAACCCAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACGTATGTACATAGAAGATGAGTTTATAGAAACAGT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTTGACGATTCCTCTAGCATTTTGTTGAATTCTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CCGTCGTAAAAAAATCATCTGCTTTTACTACTTTTACACCATG
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACAAATTCATATGTATCCATAATTACACCTTCACTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATGTTTCCGGCACTGGCTCTATGAGTCAACTAGGAAAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GGACTAGTTACTGCTCCTTGTGGCAAACGTCCTTTATATG
GTTTAGAATCTACCTATGAGGAATGAAAAC	GATTCTAAAACATAGTCGCTTTTTGTTGAACCAAAGAAATCGT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTACGAAACTGTCTCCAATTTGCAACGGGGATAATTGTT
GTTTAGAATCTACCTATGAGGAATGAAATT

>NC_011653|2|2|310593-311880|PILER-CR
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTCATTTTTGTATTATACATTTCAATTTCCTTTTTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATCACAGAATAATCTGTTGTCGATCGCCACTATTTTAAATC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTGAATAAGTGTTTCTTCAAACTTTTCAAGACTAATGGTTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CAAAAATGGCACTTGCAACACTTTCTCCTTTTAGTTTCCTCA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CGCGTTTGCCGTACTCGTCTTTGTATACACCTAATCTATAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGACTTCAGGTTCAAAGGCTTCCATTAAATCGTATATAATT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTACCTCCACAAGTGCACCATTCTCAATCTTGAAACTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AACTTTTGGAATGTTACGTTGTATGGGACTGATAAAG
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTCCCTTCATCAACTAAGTAAAAATAATTATCATTATCTAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATGATTTCGAAGTTTCAAAGTACCGCCTTCAAACCCAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACGTATGTACATAGAAGATGAGTTTATAGAAACAGT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTTGACGATTCCTCTAGCATTTTGTTGAATTCTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CCGTCGTAAAAAAATCATCTGCTTTTACTACTTTTACACCATG
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACAAATTCATATGTATCCATAATTACACCTTCACTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATGTTTCCGGCACTGGCTCTATGAGTCAACTAGGAAAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GGACTAGTTACTGCTCCTTGTGGCAAACGTCCTTTATATG
GTTTAGAATCTACCTATGAGGAATGAAAAC	GATTCTAAAACATAGTCGCTTTTTGTTGAACCAAAGAAATCGT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTACGAAACTGTCTCCAATTTGCAACGGGGATAATTGTT
GTTTAGAATCTACCTATGAGGAATGAAATT

>NC_011653|2|2|310593-311880|CRISPRCasFinder
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTCATTTTTGTATTATACATTTCAATTTCCTTTTTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATCACAGAATAATCTGTTGTCGATCGCCACTATTTTAAATC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTGAATAAGTGTTTCTTCAAACTTTTCAAGACTAATGGTTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CAAAAATGGCACTTGCAACACTTTCTCCTTTTAGTTTCCTCA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CGCGTTTGCCGTACTCGTCTTTGTATACACCTAATCTATAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGACTTCAGGTTCAAAGGCTTCCATTAAATCGTATATAATT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTACCTCCACAAGTGCACCATTCTCAATCTTGAAACTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AACTTTTGGAATGTTACGTTGTATGGGACTGATAAAG
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTCCCTTCATCAACTAAGTAAAAATAATTATCATTATCTAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATGATTTCGAAGTTTCAAAGTACCGCCTTCAAACCCAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACGTATGTACATAGAAGATGAGTTTATAGAAACAGT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTTGACGATTCCTCTAGCATTTTGTTGAATTCTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CCGTCGTAAAAAAATCATCTGCTTTTACTACTTTTACACCATG
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACAAATTCATATGTATCCATAATTACACCTTCACTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATGTTTCCGGCACTGGCTCTATGAGTCAACTAGGAAAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GGACTAGTTACTGCTCCTTGTGGCAAACGTCCTTTATATG
GTTTAGAATCTACCTATGAGGAATGAAAAC	GATTCTAAAACATAGTCGCTTTTTGTTGAACCAAAGAAATCGT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTACGAAACTGTCTCCAATTTGCAACGGGGATAATTGTT
GTTTAGAATCTACCTATGAGGAATGAAATT

Protein	Signature genes	Signature genes Name	Protein_function
NC_011653.1\|WP_041427171.1\|302426_303659_-\|glycerate-kinase	unknown	unknown	gnl\|CDD\|225254
NC_011653.1\|WP_012579490.1\|313492_314377_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl\|CDD\|274210
NC_011653.1\|WP_012579492.1\|315435_317919_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
NC_011653.1\|WP_012579487.1\|308659_309166_-\|transcription-repressor-NadR	unknown	unknown	gnl\|CDD\|224740
NC_011653.1\|WP_012579485.1\|304495_305635_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|184603
NC_011653.1\|WP_004103905.1\|301462_302422_-\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240642
NC_011653.1\|WP_012579493.1\|317936_319157_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl\|CDD\|224286
NC_011653.1\|WP_041427172.1\|303639_304515_-\|NAD(+)-synthase	unknown	unknown	gnl\|CDD\|223249
NC_011653.1\|WP_012579489.1\|313092_313503_-\|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	gnl\|CDD\|378242
NC_011653.1\|WP_012579495.1\|319913_321350_-\|TIGR01897-family-CRISPR-associated-protein	csx1	cd09728_csx1_CAS-III	gnl\|CDD\|187859
NC_011653.1\|WP_012579481.1\|298705_300346_-\|methionine-synthase	unknown	unknown	gnl\|CDD\|376761
NC_011653.1\|WP_148203261.1\|321354_322446_-\|SAVED-domain-containing-protein	unknown	unknown	gnl\|CDD\|380122
NC_011653.1\|WP_012579494.1\|319180_319903_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NC_011653.1\|WP_012579488.1\|312328_313075_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	gnl\|CDD\|213662
NC_011653.1\|WP_012579497.1\|322793_323558_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012579486.1\|307394_308663_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340874
NC_011653.1\|WP_012579482.1\|300347_301427_-\|NAD/NADP-octopine/nopaline-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|376763
NC_011653.1\|WP_004103915.1\|306245_307283_-\|heat-inducible-transcription-repressor-HrcA	unknown	unknown	gnl\|CDD\|273017
NC_011653.1\|WP_012579491.1\|314390_315443_-\|type-III-B-CRISPR-module-associated-protein-Cmr3	cmr3gr5	pfam09700_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
NC_011653.1\|WP_004103913.1\|305640_306231_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|366423

Protein	Function_ID	Function_description	E-value
NC_011653.1\|WP_041427171.1\|302426_303659_-\|glycerate-kinase	gnl\|CDD\|225254	COG2379, GckA, Putative glycerate kinase [Carbohydrate transport and metabolism].	1.10149e-145
NC_011653.1\|WP_012579490.1\|313492_314377_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	1.71055e-63
NC_011653.1\|WP_012579492.1\|315435_317919_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	1.16474e-111
NC_011653.1\|WP_012579487.1\|308659_309166_-\|transcription-repressor-NadR	gnl\|CDD\|224740	COG1827, COG1827, Predicted small molecule binding protein (contains 3H domain) [General function prediction only].	3.60254e-43
NC_011653.1\|WP_012579485.1\|304495_305635_-\|molecular-chaperone-DnaJ	gnl\|CDD\|184603	PRK14282, PRK14282, chaperone protein DnaJ; Provisional.	0
NC_011653.1\|WP_004103905.1\|301462_302422_-\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240642	cd12165, 2-Hacid_dh_6, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	6.39767e-130
NC_011653.1\|WP_012579493.1\|317936_319157_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	gnl\|CDD\|224286	COG1367, COG1367, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.54072e-14
NC_011653.1\|WP_041427172.1\|303639_304515_-\|NAD(+)-synthase	gnl\|CDD\|223249	COG0171, NadE, NAD synthase [Coenzyme metabolism].	4.0484e-71
NC_011653.1\|WP_012579489.1\|313092_313503_-\|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	2.54842e-15
NC_011653.1\|WP_012579495.1\|319913_321350_-\|TIGR01897-family-CRISPR-associated-protein	gnl\|CDD\|187859	cd09728, Csx1_III-U, CRISPR/Cas system-associated protein Csx1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; Some proteins could have an additional fusion with RecB-family nuclease domain; Core domain appears to have a Rossmann-like fold; loosely associated with CRISPR/Cas systems; also known as DxTHG family.	9.42446e-30
NC_011653.1\|WP_012579481.1\|298705_300346_-\|methionine-synthase	gnl\|CDD\|376761	pfam02310, B12-binding, B12 binding domain. This domain binds to B12 (adenosylcobamide), it is found in several enzymes, such as glutamate mutase, methionine synthase, and methylmalonyl-CoA mutase. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, which is important for B12 binding.	3.57837e-08
NC_011653.1\|WP_148203261.1\|321354_322446_-\|SAVED-domain-containing-protein	gnl\|CDD\|380122	pfam18145, SAVED, SMODS-associated and fused to various effectors sensor domain. Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. The sensing of ligands by SAVED is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.	1.72652e-10
NC_011653.1\|WP_012579494.1\|319180_319903_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.14095e-33
NC_011653.1\|WP_012579488.1\|312328_313075_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl\|CDD\|213662	TIGR01898, repair_system, CRISPR type III-B/RAMP module RAMP protein Cmr6. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1791 of Thermotoga maritima, is designated Cmr6 [sic], for CRISPR/Cas Ramp Module protein 6. This family is both closely related to and frequently encoded next to the TM1792 family of Cas proteins described by TIGR01867. The two proteins are fused in an example from Methanopyrus kandleri.	2.19934e-38
NC_011653.1\|WP_012579486.1\|307394_308663_-\|MFS-transporter	gnl\|CDD\|340874	cd17316, MFS_SV2_like, Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily. This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.6815e-50
NC_011653.1\|WP_012579482.1\|300347_301427_-\|NAD/NADP-octopine/nopaline-dehydrogenase-family-protein	gnl\|CDD\|376763	pfam02317, Octopine_DH, NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain. This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. The Pfam family consists mainly of octopine and nopaline dehydrogenases from Ti plasmids.	1.67494e-58
NC_011653.1\|WP_004103915.1\|306245_307283_-\|heat-inducible-transcription-repressor-HrcA	gnl\|CDD\|273017	TIGR00331, Heat-inducible_transcription_repressor_HrcA, heat shock gene repressor HrcA. HrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures. In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene. [Regulatory functions, DNA interactions].	1.62401e-58
NC_011653.1\|WP_012579491.1\|314390_315443_-\|type-III-B-CRISPR-module-associated-protein-Cmr3	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	4.51808e-53
NC_011653.1\|WP_004103913.1\|305640_306231_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|366423	pfam01025, GrpE, GrpE.	4.44808e-35

>NC_011653.1|WP_012579487.1|308659_309166_-|transcription-repressor-NadR
MKERLKKILSILENSNKPVKGRDLAEVLKVSRQVIVQDISVLKTKGYKIYSTREGYILEKKRDVVRKMIAVKHSEDEIYDELLKIVKAGGKVIDVIVEHPLYGEIKGRLDIETMDDISKFMALMESSNATPLLKLSGGVHIHTIEAPNKKIMNDVLDAISKYLLGVEK
>NC_011653.1|WP_012579486.1|307394_308663_-|MFS-transporter
MKIDQVVDLIVSKKEQKNLLILTSILWIIGSAGVMVMPFVVPDLVSEWNLTTVQASSLISSVFIGMLLGALFSGIILDYFGRKIGVIFYLLVTVIFTVLFGFSKSFGSAYVFRLLSGFGYGGLLPSVNTYLSEYTSIRLRGRYLVILEASWAVGSILIALFAVTLGEKLGWRWDFYIFSIGIISLIPFFRKKDTPKYIFEKRGVEGLKKIFNKVPENIEEIEKVKVTFSGLFRKEHIKQTILVIISWFVVSFVYYALFSWAPKIFIASLGITITKAKWYTFFVYLAQLPGYLSVAYLIEKWGRKKTLATYFIGMGLSSFLLLLATGNLSFLFIVLILSFFTLGVWGLVYAYTPELFPTSFRGTANGVAGATARIAGIIAPYFTGYFVDKSIVAALSFVSLFAIFAAVMTLVLGVETKDKAVN
>NC_011653.1|WP_004103915.1|306245_307283_-|heat-inducible-transcription-repressor-HrcA
MADKWGEKMKELSTRQEQILYCLVREYVKSGTPVSSQKILESTNLEWSGATVRNDMRKLDYLGYVFQPHTSAGRVPTDKGLRFYVNEILKLRKETKKSGSSIDVSIDFPIGDLDKIIQGAAKLLATTVKAFVIIEKPNPMYLRIRRVVLTPVTKNFSIVNIITELGLTSVLPIQHSEIYNIQEIEEFLNKSLDGILLSEFRAKLREVVERFSWVGGRLKEFIELSEKIASEKYEEYITEGVFNLVNAKRFDEEKLKEIVRFSTNEEYYSKIFELGEGIFIGKEHNIKNFEQYSILIMPYFVFNREVGKIAVIFDKFSDYNRVFDSVEYVVNRLTEYFTVVARNVE
>NC_011653.1|WP_004103913.1|305640_306231_-|nucleotide-exchange-factor-GrpE
MEKKEMKKEKMIENEKVENVKEDANKEKKEKGKEKDLEKIIDEQSKKIEELENQLKEFENYARILKSQFENYKKDVAREKEQISISTIGRIVEKLVPIIDDFKRAFKNVDDETKKTQFFKGMEIIYKNLFKILEGLGLQEIKVGDKFDPFEHEAVERVEDEEKEEYSIVEIVEDGYKFNGRVLKPVKVKVSIKPRR
>NC_011653.1|WP_012579485.1|304495_305635_-|molecular-chaperone-DnaJ
MAKKDYYEILGVSRNASQEEIRQAYKQLIKKWHPDRNHQNRKEAEEKFKEIQEAYEVLSDPEKRAMYDRFGYVGDVPPNAGSGGGFGGFGGFGGFEDIFKDFGDFINNDIFNIFFGDQRTSSRQKQRRAKRGEDINITVDVPFEQVFTGTTIPIEYDRYEVCSHCNGEGVEPGSGWVSCPKCHGTGVVREERRTFLGVIVNQYTCNQCGGTGKIPGETCHVCGGSGRIRKRHRVEVKIPAGVDNGTVIRVQGKGNAGYNGGGYGDLYVNVRITGHIDFERRGNDLIKEIKIDYVEAILGTKVKIKMPDGRVKEVKIPSGVQDGENIYVYGEGVPDMRTGRRGDLILKIKVDIPKRVSRSEKKLLKEIAKLRGKDVDEEE
>NC_011653.1|WP_041427172.1|303639_304515_-|NAD(+)-synthase
MLTKKSEKIVNFLRETVAQYNFRGLVLGVSGGLDSAVVLALLVKAFDRDKIKCFILPERDSPKDSVKDAVFVCKYFGVEYEIKNITKILRALGIYKYYPPAFFVPWKVKENFAKKRWQKYKEKGNPFEFDIEGIEDEEFLKGISYYRAKHRVRMVYLYKEAERRNYAVVGTTNKTEFLTGLYVKWGDDSTDIEPILHLYKTQVYELAKELNVPEKIIMKPASPDLIPGIGDEEIFGLDYSTLDRILDKLLNNKSLDGEDPEKVKLVKRLYQIGKKRNSLRNVSMVDDLYGT
>NC_011653.1|WP_041427171.1|302426_303659_-|glycerate-kinase
MIYMELKTLAKKIIFDTLEDIQPEKLVKEKLKEIRVDKKVYVLSIGKAAWKMAKAASDVLDIEYGIVITKYGYNFGNIENFDIFEAGHPLPDENSLSATKFAVEKFSKLSKDDILLFLISGGGSSTFELLQDGLSLDDLKDVTTQLLKSGADIKEINTIRSRLSKVKGGRFLNFVKSKVITLVLSDVLENDLRYIASGPTYEACSTFEDAYKIIKKYNLDFNENIINVLKKDVKINKQIDVEHYIIGSIDIACDILEKHARKYNLNTLVLTTRLDCEAKEAGKFIASIAKSSKLKTPYCIIFGGETVVKVKGSGKGGRNQELCYSAALEIENMKDVVIASVGTDGTDGPTDAAGAIVDGKTISKVRKFSNDPNEFLLNNDTYNALKLSGDLLITGPTGTNLNDIGFILKG
>NC_011653.1|WP_004103905.1|301462_302422_-|2-hydroxyacid-dehydrogenase
MKALVLTKITDYFRKKMEEFNEIEWYTPKDIDYVLEDVEIIVTGYLTEEQVDKAKKLKAIFIPWTGADKLPWKKIKERNIIVSNSHGNGKMVAERALSLSLALLGRIIEFHNDLEKGIWHGFAVGFKEDDYWYSLQGKNVAILGTGVIGRHLAKLLKGFDCHITGFKRSKEQIAGFDRIVTSIEEAISDAQVIYLALPLTEKTYKIIDEKMFEKMRGKFLINVGRGELIDEYSLFKALNENILRGFASDVWYKYPSKDEQVILPFNFPIHKFKNVVLSPHVGGFTIEGQQGRIDELFENIESFLKKGFPKTAVDPELMY
>NC_011653.1|WP_012579482.1|300347_301427_-|NAD/NADP-octopine/nopaline-dehydrogenase-family-protein
MNITVIGAGNGGLALAGFLAMRGFAVTLYNRSLKRISSFIKSRVIKLEGEITGSVKIKNVTNNLEEALKDAELVMIVVPAFAHADIAEKVSKYVKDGQIFILNPGRTFGALEFYNIFKKNRVDKDVIIAETQTFLFASRTSNPGVSHIFRVKNAVPISAIPSTKNEKLKKVIEDIVPEFQVVDSIIYTSFNNIGAVFHPATLILNSGRVESTFGKFEFYLEGITPSVARVLEKIDAERCSVARTLGIEPMTAKDWLNYAYDVLGNNLYEAIHNNAGYQGIIAPPSLQNRYIFEDVPMSLVPISEMAKKLGINTPAIDSIIYLSSIMMGRDFYREGRTLERLGISKLSLDEIKNLIYKGV
>NC_011653.1|WP_012579481.1|298705_300346_-|methionine-synthase
MVKKILGGSIGSCVHVAGVLNFLKLAEKEGYKSIYLGGAVPLEKFVGAIVESDPDIVAISYRLDPKALEKLLNEFYKMIKEKNLLDKVYIFGGTVETAAVARKFEFISKIFDGSQDIDEVILWLRNAKKDKEKKEIPPQFLPERIIYKRPYPLIRHHIGLASLEETEKHIRILAESGLLDIISLAPDQNCQQYFFEPEKMDRKQDGAGGAPIRTKEDFIRLYNASRTGNYPLMRCYSGTSNLVEFSKLLKETINNAWAAIPLTWYSDLDRRSDRPLLEAIKENQEAIKWNAENNVPVEINEAHQWSLRYAHNAIEVATFYLAAYNAKKLGVRHYVAQYMLSTPPGLSPKFDLAKQIAKKQLIETLEDETFTSYTMIRTGLLSFPADEHSAMGQLVSTMFYGMYLKPDIIHVVSYSEAIRRATSKEIIESVKMVKQAMRNAMNGLPDFLEDKSIRNRVEVLKNEAMMIIDAIKQIGKGFDDPLIEPEVIYNAVKLGILDAPGLKGMSVAKGRFETQIIDGACYAVDENGKILTEEKRLEIIRKEAGM
>NC_011653.1|WP_012579488.1|312328_313075_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MKVGYKEDLGNKNIKSFSLFYDKYVYYNLHKNLSEKKNEDKLKDLDNLLKVFFNNNIYIYENSKILNDVFSKALKQLETSGYQIYEKSFELSSPLLIGSGIPSAYEVGIYLNRNYGLPVIPGQSIKGSFKAFLDEIDENDLIFFGNNENSSEIFFFDAVPEKYKLGIDILNPHFKEYYLSENVPNDVYQPVPINFISVFEGTYVFRYVIVSEKNDDNKNKKISEYFEEFLTIYGIGAKTSMGYGRFKK
>NC_011653.1|WP_012579489.1|313092_313503_-|type-III-B-CRISPR-module-associated-protein-Cmr5
MRNKIEIKNFSQNKIKENLKEMESNDELKKSYKSLVKSLGALVLQNGLYASIVFIISKTKDKNNYYYVLKDIQKFLKEYFKDSYVVNNKDIKDIKQEVLEFLESESFKKAYKQFSEQFIEFIKWHRRYVDIYIDID
>NC_011653.1|WP_012579490.1|313492_314377_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MNHEVGRIGFFYAVTQIHAGKGFDVGIVDQPIQREIHTRFPVINGVKGAIRNEISRLININYNDITQIFGTEFQDNEASEAGKVSFSEGKLAFYPVRSIDRGIVWITCPLILSRLKIAFDVVGLEEFKKLIEKINISYKEDYKALSTINDSKICLEEFEQDIKYSKDLMSFVNHLRNIFPDERLFERFSSNLVILSDKDFSYFVTNSTEVIARIRINPQKRTVDKGALWYEEYIPQDSVLFFISKLLVNNADYLLKKIDELNSKFLNIGGNASIGKGIVYISFLPFKGEDKNEK
>NC_011653.1|WP_012579491.1|314390_315443_-|type-III-B-CRISPR-module-associated-protein-Cmr3
MSKVKVLKFIPIDWVSFRKSKNFSTFENTIFPNIKTFYGAIFSAYFRKRGTKNAIKEIEKMIEEKLINLIGPFIVSERNEIYFRKPANLKLRKICKNENSCEYEYEYYKGFPCQDSFAVDDKNLRYIKYSNIDNLSEEGITFISISDLETFKKSSDKKLYLNLHKYNKNLPFSIERKVGIALDNKKRMVDKEHGAFYLLSTYRFRDGAGFGVFIDEKTEQFLNENKINTVNIGSKGKLARLEIFEIETDLFSKESSSKIKGLMLLTPAVFKNGFLPTSEYIRQKIVAVCNYKPEVYSGWDLKKNKPGKMFRIVPPGSVFFTEEKYLENLELTEEFNEYNYGKFIVLENCE
>NC_011653.1|WP_012579492.1|315435_317919_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MNEINWKKKVEAFLHDPVNKMANIRGHKNLAKTLLNKVGLKQNNNPRYDYIASAATRILFPQEVTKIKRNSEQIRIEFDESKFFHPFSGNDLSEYHKVKEKIKNIDEENFISKLAKIEDYKKLAYRLWWEIPKISDYSYLILEDTRLTNQSIIDHLDISSAFATADEESNGYLILSVSIGPVQEFIAAGRKIRDLRSGSYLLSYLTFKGIQVIGEKFGFDCIIFPDLRNNYLVKKYLENIDDFFKNNSEKFLMQPEVASLPNVFTAIIPYKEEYIDKNSEENIEILIKSAIKKEIDNISKFIFDLIKNKKLKEYTFSKEIENNPELYWNRQVNIFPDIIVESVMFYIFGDEKLNKENWIFKEWEKFIGSNELENYYEQLSKLENTYSLSEANMYNYHTKILQAKSFLRKNTRNFKALIEDFETPGDDLSGGLKSLVIYEKGDRKENLSALSVIKREFYRYLKNVGLDEAGEGIRNTRPISYEDSEDDEENNKESIVKEYKLGVLLMDGDQMGKWITGDKIEDNLKNVHPKAKEFLEKQSSDYLDFLKKYKLINPTYQKSISRTLNKFSYFVPHIVREFEGELIYAGGDDVLAIFPANRVLEAANKIRKVYSGIGNVRVEVNKNDGKSEIYEFRNGFCYKDDLPLFNMMGEKATMSAGIVVCNPKLNLSLVLDEVRKAEKEAKNEGRNRFSLRTIRRSGKITNLVFEWEYLSKSKEVFDILDEVEFVYSLFEKNETKKEKSYNSFFRRLKVEYEKLEISKKEFIEQVIPYVLKRIKKIKGIEKVIEVLEKYVQILEENSKNFENNNLEKFIDLLLEYEYIKRKVDKYE
>NC_011653.1|WP_012579493.1|317936_319157_-|type-III-B-CRISPR-module-RAMP-protein-Cmr1
MKNLETLKFNIEFISPLINRRGKYKDSILLPQTVRGVMRYYFRATAARVFGNNYKKIKELEDIIFGSINNKSFFDVTVTLQKERKIKLSELKALRYPLYGVIFTKKNEIKFNEKISLLDSRSEFLVNFIFFKSFFKRKIKDCNKVDEYFHKFKEFIKDLFVLISLVGGFGAKVKKGFGQFVIRNIERDIKLEDIGTILKNLEEKIKYLDKIFIKENEKNKESITNNSSSISNEAFDFPAFVDGFFYVYKLKKEFYSYENALRNIYFSKKNNFSYLNLKKKLRGSAFKDAIQNFNDKKKVDFNDALLGLPVLFFYGKANYKLNALDDKGNEYRKSSLLTIKLWRERNGKYKVYLIVLLSKIHLKNSKIVLKKIVQTNGSEGKSINIDFDYNKLKNTIEKYKELNKII
>NC_011653.1|WP_012579494.1|319180_319903_-|CRISPR-associated-endoribonuclease-Cas6
MRIYLDLDFEKLELPIHYNHILQSIIINMIDSSGYRKFIHDEGYVLGKRKFKLYTFSRLLGKFQIFGNKIAFFNGARLIISSLDDAMVEYIINYILKKGYINVLGEKIYVKAAVLKSLPSANYLRVSTKSPVVVYSTLFNYENKKETIFYEPDSSKFLSLVYENILKKYTAFYGSISKNNIEIKHVGKNPKRVKVVYKNTVIFGWLTAFDIYGDFELLKVAYDAGIGMKNSMGFGCVELI
>NC_011653.1|WP_012579495.1|319913_321350_-|TIGR01897-family-CRISPR-associated-protein
MKLFFSTFGKISNYKEVEYSIDYNENTFESPFLPDLMCKAFGVDTTELFLLDTLVEKNDLLKEDFKYEDIITSLENKYFNYFKSKDYKGNLNLHIIPGVGSYKEFRFVGNMNDTYYMTLIQLLNIFSRPEVINSEEIEVILDISFGINYQSNVLYRTLMDILPVLAYFKKVRFKLTNAEPVINTSAEGKNKINVYVVEEKVFEQSISYKKDFAKKTISVFRGLSINERKEVGKNYIREFEKRLRNEKNMGLNNVFLNLELYLKSIYYGLPLLYLYAMNGADFKYVVDKSLEMYNSAIEIRDSNENLKMVLRKLEFSEGIKYLVLGSIFKIYFENIYGTKYCTEIPYDELKKLSNFIWKIDEFKNQISLVLEKEIKEIESLFDYIEEGEEILFDLEMLKSRKNESIECEEKVDENTKKELEHENDELKKQNSIENFSRKERNFIAHGSLSKNTFYLKKYNSMVCIRLNEEEICKLGKAI
>NC_011653.1|WP_148203261.1|321354_322446_-|SAVED-domain-containing-protein
MKSSLEKIESLVGKKLIVIFDSEFKGNSFELAVAIGSLCKKIPKNIAFTGEIDEKGNIKRNIEYLDLKMKICSENNLKLISAFDVDNLFELKEFFEAKKIHIPILISLMAKDKEYIRTSYEELKEAVNEKFEIKYSDIFEKIYDVNKVFVKDSLNDDWGQVLKEVNSLLYKIISNRGIPHIAIMGPASFSMALGIALGVQNPLVVYHKAGIEYKPVIDLTDNVRKVKNIVSDYKFVKYSVENENGKNCAFILYFASHNPYDAVKNFLSKNNIDSKLVLIEPNFGKGNLPAEDWSEIVSEIMSVTQNIQFKHSCENVFFFMSCPVPLAFGVGLSFGDFAKGSIFHFDKNTGDYIEVFKIEKIRG
>NC_011653.1|WP_012579497.1|322793_323558_-|hypothetical-protein
MSFLKKEFELYKNLFGKYKLNIESLKIVPEGKALEAGDVFVIYGDILVYGVVIEKNGDLAECVLLSQDVFLSSSKALKIKINHLVDYVYVTHVNFYIEDNFAKNYCQVIINVKEDINKIAENVEELEEQIYTGPRKEYFDLLIDQISLLYDIFFEKIFDETKEEDKIIEINIPYASEFALVAGTNSLRGENFVGIVENNTLKVYLQDNAIGKKGKLIFKNQVIYEGELPNAFVSNNIKVSVEDLKKFLVIEVID

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Crispr_ID: NC_011653_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011653_3

326883-329288

TypeIII

Consensus_repeat	Method
GTTTAGAATCTACCTATGAGGAATGAAAAC	PILER-CR
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CRISPRCasFinder
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CRT
GTTTAGAATCTACCTATGAGGAATGAAAAC	PILER-CR

34 spacers

cas2,cas1,csx1,cas6

The CRISPR arrays of NC_011653_3

>merge|NC_011653|3|326883-329288|PILER-CR,CRISPRCasFinder,CRT,PILER-CR
GTTTTCATTCCTCATAGGTAGATTCTAAACATATCAAATTCGCCAAGCCGCTGTTCCCAAATATTCCGTTTTCATTCCTCATAGGTAGATTCTAAACATGATGACTATTAGTGCATACCTGATTATATTGGCGTCTATCTACGTTTTCATTCCTCATAGGTAGATTCTAAACGAAACATTAGGTAATCGACAAGATGAACTGTTTATGGAAGTTTTCATTCCTCATAGGTAGATTCTAAACTACAAAGTTAGAATTTGACAAAAAAGGAATAAAAGAATTTGAAGTTTTCATTCCTCATAGGTAGATTCTAAACACCTGAAAAGACACAGGAGGGAAAAATTCCTCATGAGCCAGTTTTCATTCCTCATAGGTAGATTCTAAACTGAGAATTGGTGTTCGAAGATATTTTAGCTATGAATATACGTTTTCATTCCTCATAGGTAGATTCTAAACTCAAAAATTTTGAAAAACTGATGAATGAAGTAATTCAACGTTTTCATTCCTCATAGGTAGATTCTAAACTATTCTAATTATCCAGGAGCTCGAGTTACAATTCACGTTTTCATTCCTCATAGGTAGATTCTAAACTTCGACTTCGACTCCAAAAACCTTATTCGGATCTTTATTTGTTTTCATTCCTCATAGGTAGATTCTAAACCTCATTAAACAAAACAAAAAGAAAAAACTTACAAAAGGAAGTTTTCATTCCTCATAGGTAGATTCTAAACTAGGGCTCCCCGTGTGGGGGATGACCGAAAGGGACCTGGCAATGTTTTCATTCCTCATAGGTAGATTCTAAACGCAAAAATGGGGGCCAATCACAGGCCCCTATTTTGTTGCGTTTTCATTCCTCATAGGTAGATTCTAAACAAACTAAAAATGGGCTCAAACGCCGCTTTTACGAGTTTTCATTCCTCATAGGTAGATTCTAAACAGTTTTTGGAAAAATAGTGCATGAGATGATAGCTAAACAATTGTTTTCATTCCTCATAGGTAGATTCTAAACTCTTGTTCTGGTTGAAGGAACACCGCAGACAAGAAAACATCAGTTTTCATTCCTCATAGGTAGATTCTAAACATTTCAATGCCTATCCATCTTCTACCTAATTGTTCTGCGTTTTCATTCCTCATAGGTAGATTCTAAACGAAATATGCAGAAATTGAGAAAGTAGATTGGAAACGTTTTCATTCCTCATAGGTAGATTCTAAACGAAAAATTCCTCATGAGCCACAGTATCCTGTGTCTGAGTAGGGGTTTTCATTCCTCATAGGTAGATTCTAAACATTTCAATGCCTATCCATCTTCTACCTAATTGTTCTGCGTTTTCATTCCTCATAGGTAGATTCTAAACCTAAACATACTACAGCGGAGCAGGTAATAAACTGTTATATCTAAGTTTTCATTCCTCATACGTAGATTCTAAACCGCAATATTTAGAGCTTTAATGTTTCAAAAATGGCACCAATACAGGTTTTCATTCCTCATAGGTAGATTCTAAACCTTTAGAGCTTTAATGTTTCAAAAATGGCACCAATACAGTGGTCTTGTTTTCATTCCTCATAGGTAGATTCTAAACTAATGTTTCAAAAATGGCACCAATACAGTGGTCTTTGTTTTCATTCCTCATAGGTAGATTCTAAACTACAACTCAGACCCAGAAGCTGAGTGGATGTTAGATGAATAGTTTTCATTCCTCATAGGTAGATTCTAAACGGAAACTATAGAAGAAAAGTTTGTGGTTATAAAACGTTTTCATTCCTCATAGGTAGATTCTAAACATAATAATAATAGAAAACAGATTATTCTGTGATTTTCGTTTTCATTCCTCATAGGTAGATTCTAAACCAAAACTCCTCGGCAACAAAATTGTGTTTTCACTTGGAACAACGTTTTCATTCCTCATAGGTAGATTCTAAACATTTGAATATGATGTAGGAATCGAAAAAGGATTAATCACCGGTTTTCATTCCTCATAGGTAGATTCTAAACATTCTTCTGTGATTTTCCAATCGCGGATTTTGGTCACGGTTTTCATTCCTCATAGGTAGATTCTAAACGAGGAATTCAAAAATTTTCGAAATTTCGAAGACCTCGAACTGTTTTCATTCCTCATAGGTAGATTCTAAACTTGAAAAGGGGGTGATTACCGCAACGTTCGAGATAAGTTTTCATTCCTCATAGGTAGATTCTAAACTCGGTGGGTTTAGAAATGCCCAATGTGGGCAAAAACAAATAAGGGTTTTCATTCCTCATAGGTAGATTCTAAACGTATAACACAAAGATGAAAATTTCCAAGGAGGGTGTCGAGTTTTCATTCCTCATAGGTAGATTCTAAACAGTTTAAGAACTTTAGATTTTTTGAAGACCTCGAATTGTTTTCATTCCTCATAGGTAGATTCTAAAC

>NC_011653|3|3|326883-328235|PILER-CR
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATATCAAATTCGCCAAGCCGCTGTTCCCAAATATTCC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATGATGACTATTAGTGCATACCTGATTATATTGGCGTCTATCTAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAACATTAGGTAATCGACAAGATGAACTGTTTATGGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TACAAAGTTAGAATTTGACAAAAAAGGAATAAAAGAATTTGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACCTGAAAAGACACAGGAGGGAAAAATTCCTCATGAGCCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAGAATTGGTGTTCGAAGATATTTTAGCTATGAATATAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCAAAAATTTTGAAAAACTGATGAATGAAGTAATTCAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TATTCTAATTATCCAGGAGCTCGAGTTACAATTCAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTCGACTTCGACTCCAAAAACCTTATTCGGATCTTTATTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTCATTAAACAAAACAAAAAGAAAAAACTTACAAAAGGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TAGGGCTCCCCGTGTGGGGGATGACCGAAAGGGACCTGGCAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCAAAAATGGGGGCCAATCACAGGCCCCTATTTTGTTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAACTAAAAATGGGCTCAAACGCCGCTTTTACGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AGTTTTTGGAAAAATAGTGCATGAGATGATAGCTAAACAATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCTTGTTCTGGTTGAAGGAACACCGCAGACAAGAAAACATCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTCAATGCCTATCCATCTTCTACCTAATTGTTCTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAATATGCAGAAATTGAGAAAGTAGATTGGAAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAAAATTCCTCATGAGCCACAGTATCCTGTGTCTGAGTAGGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTCAATGCCTATCCATCTTCTACCTAATTGTTCTGC
GTTTTCATTCCTCATAGGTAGATTCTAAACCTAAACATACTACAGCGGAGCAGGTAATAAACTGTTATATCTAAGTTTTCATTCCTCATACGTAGATTCTAAACCGCAATATTTAGAGCTTTAATGTTTCAAAAATGGCACCAATACAGGTTTTCATTCCTCATAGGTAGATTCTAAACCTTTAGAGCTTTAATGTTTCAAAAATGGCACCAATACAGTGGTCTTGTTTTCATTCCTCATAGGTAGATTCTAAACTAATGTTTCAAAAATGGCACCAATACAGTGGTCTTTGTTTTCATTCCTCATAGGTAGATTCTAAACTACAACTCAGACCCAGAAGCTGAGTGGATGTTAGATGAATAGTTTTCATTCCTCATAGGTAGATTCTAAAC	GGAAACTATAGAAGAAAAGTTTGTGGTTATAAAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATAATAATAATAGAAAACAGATTATTCTGTGATTTTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAAAACTCCTCGGCAACAAAATTGTGTTTTCACTTGGAACAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTGAATATGATGTAGGAATCGAAAAAGGATTAATCACCG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTCTTCTGTGATTTTCCAATCGCGGATTTTGGTCACG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAGGAATTCAAAAATTTTCGAAATTTCGAAGACCTCGAACT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTGAAAAGGGGGTGATTACCGCAACGTTCGAGATAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCGGTGGGTTTAGAAATGCCCAATGTGGGCAAAAACAAATAAGG


>NC_011653|3|3|326883-329288|CRISPRCasFinder
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATATCAAATTCGCCAAGCCGCTGTTCCCAAATATTCC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATGATGACTATTAGTGCATACCTGATTATATTGGCGTCTATCTAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAACATTAGGTAATCGACAAGATGAACTGTTTATGGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TACAAAGTTAGAATTTGACAAAAAAGGAATAAAAGAATTTGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACCTGAAAAGACACAGGAGGGAAAAATTCCTCATGAGCCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAGAATTGGTGTTCGAAGATATTTTAGCTATGAATATAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCAAAAATTTTGAAAAACTGATGAATGAAGTAATTCAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TATTCTAATTATCCAGGAGCTCGAGTTACAATTCAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTCGACTTCGACTCCAAAAACCTTATTCGGATCTTTATTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTCATTAAACAAAACAAAAAGAAAAAACTTACAAAAGGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TAGGGCTCCCCGTGTGGGGGATGACCGAAAGGGACCTGGCAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCAAAAATGGGGGCCAATCACAGGCCCCTATTTTGTTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAACTAAAAATGGGCTCAAACGCCGCTTTTACGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AGTTTTTGGAAAAATAGTGCATGAGATGATAGCTAAACAATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCTTGTTCTGGTTGAAGGAACACCGCAGACAAGAAAACATCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTCAATGCCTATCCATCTTCTACCTAATTGTTCTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAATATGCAGAAATTGAGAAAGTAGATTGGAAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAAAATTCCTCATGAGCCACAGTATCCTGTGTCTGAGTAGGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTCAATGCCTATCCATCTTCTACCTAATTGTTCTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTAAACATACTACAGCGGAGCAGGTAATAAACTGTTATATCTAA
GTTTTCATTCCTCATACGTAGATTCTAAAC	CGCAATATTTAGAGCTTTAATGTTTCAAAAATGGCACCAATACAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTTTAGAGCTTTAATGTTTCAAAAATGGCACCAATACAGTGGTCTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TAATGTTTCAAAAATGGCACCAATACAGTGGTCTTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TACAACTCAGACCCAGAAGCTGAGTGGATGTTAGATGAATA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGAAACTATAGAAGAAAAGTTTGTGGTTATAAAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATAATAATAATAGAAAACAGATTATTCTGTGATTTTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAAAACTCCTCGGCAACAAAATTGTGTTTTCACTTGGAACAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTGAATATGATGTAGGAATCGAAAAAGGATTAATCACCG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTCTTCTGTGATTTTCCAATCGCGGATTTTGGTCACG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAGGAATTCAAAAATTTTCGAAATTTCGAAGACCTCGAACT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTGAAAAGGGGGTGATTACCGCAACGTTCGAGATAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCGGTGGGTTTAGAAATGCCCAATGTGGGCAAAAACAAATAAGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GTATAACACAAAGATGAAAATTTCCAAGGAGGGTGTCGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AGTTTAAGAACTTTAGATTTTTTGAAGACCTCGAATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC

>NC_011653|3|3|326883-329288|CRT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATATCAAATTCGCCAAGCCGCTGTTCCCAAATATTCC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATGATGACTATTAGTGCATACCTGATTATATTGGCGTCTATCTAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAACATTAGGTAATCGACAAGATGAACTGTTTATGGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TACAAAGTTAGAATTTGACAAAAAAGGAATAAAAGAATTTGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACCTGAAAAGACACAGGAGGGAAAAATTCCTCATGAGCCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAGAATTGGTGTTCGAAGATATTTTAGCTATGAATATAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCAAAAATTTTGAAAAACTGATGAATGAAGTAATTCAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TATTCTAATTATCCAGGAGCTCGAGTTACAATTCAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTCGACTTCGACTCCAAAAACCTTATTCGGATCTTTATTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTCATTAAACAAAACAAAAAGAAAAAACTTACAAAAGGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TAGGGCTCCCCGTGTGGGGGATGACCGAAAGGGACCTGGCAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCAAAAATGGGGGCCAATCACAGGCCCCTATTTTGTTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAACTAAAAATGGGCTCAAACGCCGCTTTTACGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AGTTTTTGGAAAAATAGTGCATGAGATGATAGCTAAACAATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCTTGTTCTGGTTGAAGGAACACCGCAGACAAGAAAACATCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTCAATGCCTATCCATCTTCTACCTAATTGTTCTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAATATGCAGAAATTGAGAAAGTAGATTGGAAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAAAATTCCTCATGAGCCACAGTATCCTGTGTCTGAGTAGGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTCAATGCCTATCCATCTTCTACCTAATTGTTCTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTAAACATACTACAGCGGAGCAGGTAATAAACTGTTATATCTAA
GTTTTCATTCCTCATACGTAGATTCTAAAC	CGCAATATTTAGAGCTTTAATGTTTCAAAAATGGCACCAATACAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTTTAGAGCTTTAATGTTTCAAAAATGGCACCAATACAGTGGTCTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TAATGTTTCAAAAATGGCACCAATACAGTGGTCTTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TACAACTCAGACCCAGAAGCTGAGTGGATGTTAGATGAATA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGAAACTATAGAAGAAAAGTTTGTGGTTATAAAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATAATAATAATAGAAAACAGATTATTCTGTGATTTTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAAAACTCCTCGGCAACAAAATTGTGTTTTCACTTGGAACAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTGAATATGATGTAGGAATCGAAAAAGGATTAATCACCG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTCTTCTGTGATTTTCCAATCGCGGATTTTGGTCACG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAGGAATTCAAAAATTTTCGAAATTTCGAAGACCTCGAACT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTGAAAAGGGGGTGATTACCGCAACGTTCGAGATAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCGGTGGGTTTAGAAATGCCCAATGTGGGCAAAAACAAATAAGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GTATAACACAAAGATGAAAATTTCCAAGGAGGGTGTCGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AGTTTAAGAACTTTAGATTTTTTGAAGACCTCGAATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC

>NC_011653|3|4|328568-329152|PILER-CR
	ATATCAAATTCGCCAAGCCGCTGTTCCCAAATATTCC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATGATGACTATTAGTGCATACCTGATTATATTGGCGTCTATCTAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAACATTAGGTAATCGACAAGATGAACTGTTTATGGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TACAAAGTTAGAATTTGACAAAAAAGGAATAAAAGAATTTGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACCTGAAAAGACACAGGAGGGAAAAATTCCTCATGAGCCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAGAATTGGTGTTCGAAGATATTTTAGCTATGAATATAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCAAAAATTTTGAAAAACTGATGAATGAAGTAATTCAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TATTCTAATTATCCAGGAGCTCGAGTTACAATTCAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTCGACTTCGACTCCAAAAACCTTATTCGGATCTTTATTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTCATTAAACAAAACAAAAAGAAAAAACTTACAAAAGGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TAGGGCTCCCCGTGTGGGGGATGACCGAAAGGGACCTGGCAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCAAAAATGGGGGCCAATCACAGGCCCCTATTTTGTTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAACTAAAAATGGGCTCAAACGCCGCTTTTACGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AGTTTTTGGAAAAATAGTGCATGAGATGATAGCTAAACAATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCTTGTTCTGGTTGAAGGAACACCGCAGACAAGAAAACATCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTCAATGCCTATCCATCTTCTACCTAATTGTTCTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAATATGCAGAAATTGAGAAAGTAGATTGGAAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAAAATTCCTCATGAGCCACAGTATCCTGTGTCTGAGTAGGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTCAATGCCTATCCATCTTCTACCTAATTGTTCTGC
GTTTTCATTCCTCATAGGTAGATTCTAAACCTAAACATACTACAGCGGAGCAGGTAATAAACTGTTATATCTAAGTTTTCATTCCTCATACGTAGATTCTAAACCGCAATATTTAGAGCTTTAATGTTTCAAAAATGGCACCAATACAGGTTTTCATTCCTCATAGGTAGATTCTAAACCTTTAGAGCTTTAATGTTTCAAAAATGGCACCAATACAGTGGTCTTGTTTTCATTCCTCATAGGTAGATTCTAAACTAATGTTTCAAAAATGGCACCAATACAGTGGTCTTTGTTTTCATTCCTCATAGGTAGATTCTAAACTACAACTCAGACCCAGAAGCTGAGTGGATGTTAGATGAATAGTTTTCATTCCTCATAGGTAGATTCTAAAC	GGAAACTATAGAAGAAAAGTTTGTGGTTATAAAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATAATAATAATAGAAAACAGATTATTCTGTGATTTTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAAAACTCCTCGGCAACAAAATTGTGTTTTCACTTGGAACAAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTGAATATGATGTAGGAATCGAAAAAGGATTAATCACCG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTCTTCTGTGATTTTCCAATCGCGGATTTTGGTCACG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAGGAATTCAAAAATTTTCGAAATTTCGAAGACCTCGAACT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTGAAAAGGGGGTGATTACCGCAACGTTCGAGATAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCGGTGGGTTTAGAAATGCCCAATGTGGGCAAAAACAAATAAGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011653.1\|WP_012580542.1\|330235_331366_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_011653.1\|WP_012579498.1\|323567_324242_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_114702294.1\|324711_324990_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_011653.1\|WP_012579501.1\|331985_333188_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|349949
NC_011653.1\|WP_004103971.1\|336302_336530_-\|DNA-directed-RNA-polymerase-subunit-omega	unknown	unknown	gnl\|CDD\|234744
NC_011653.1\|WP_004103949.1\|324244_324658_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_004103959.1\|324986_325970_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NC_011653.1\|WP_012579502.1\|333171_334122_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|223609
NC_011653.1\|WP_004103981.1\|337147_337432_-\|DUF370-domain-containing-protein	unknown	unknown	gnl\|CDD\|179823
NC_011653.1\|WP_012579504.1\|336513_337146_-\|guanylate-kinase	unknown	unknown	gnl\|CDD\|234719
NC_011653.1\|WP_012579495.1\|319913_321350_-\|TIGR01897-family-CRISPR-associated-protein	csx1	cd09728_csx1_CAS-III	gnl\|CDD\|187859
NC_011653.1\|WP_004103963.1\|326294_326672_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_004103969.1\|335238_336246_+\|M42-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349906
NC_011653.1\|WP_004103961.1\|325984_326248_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_011653.1\|WP_012579503.1\|334221_335238_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349906
NC_011653.1\|WP_012579500.1\|331503_331923_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223976
NC_011653.1\|WP_012579494.1\|319180_319903_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NC_011653.1\|WP_148203261.1\|321354_322446_-\|SAVED-domain-containing-protein	unknown	unknown	gnl\|CDD\|380122
NC_011653.1\|WP_012579505.1\|337449_338325_-\|YicC-family-protein	unknown	unknown	gnl\|CDD\|236993
NC_011653.1\|WP_012579497.1\|322793_323558_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_011653.1\|WP_012580542.1\|330235_331366_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	4.60903e-47
NC_011653.1\|WP_012579502.1\|333171_334122_-\|radical-SAM-protein	gnl\|CDD\|223609	COG0535, COG0535, Predicted Fe-S oxidoreductases [General function prediction only].	1.54576e-52
NC_011653.1\|WP_012579501.1\|331985_333188_-\|MFS-transporter	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	3.90492e-14
NC_011653.1\|WP_004103971.1\|336302_336530_-\|DNA-directed-RNA-polymerase-subunit-omega	gnl\|CDD\|234744	PRK00392, rpoZ, DNA-directed RNA polymerase subunit omega; Reviewed.	6.7237e-15
NC_011653.1\|WP_012579500.1\|331503_331923_-\|peptidylprolyl-isomerase	gnl\|CDD\|223976	COG1047, SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones].	8.33133e-39
NC_011653.1\|WP_012579503.1\|334221_335238_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|349906	cd05656, M42_Frv, M42 Peptidase, endoglucanases. Peptidase M42 family, Frv (Frv Operon Protein; Endo-1 4-Beta-Glucanase; Cellulase Protein; Endoglucanase; Endo-1 4-Beta-Glucanase Homolog; Glucanase; EC. 3.2.1.4) subfamily. Frv is a co-catalytic metallopeptidase, found in archaea and bacteria, including Pyrococcus horikoshii tetrahedral shaped phTET1 (DAPPh1; FrvX; PhDAP aminopeptidase; PhTET aminopeptidase; deblocking aminopeptidase), phTET2 (DAPPh2) and phTET3 (DAPPh3), Haloarcula marismortui TET (HmTET) as well as Bacillus subtilis YsdC. All of these exhibit aminopeptidase and deblocking activities. The HmTET is a broad substrate aminopeptidase capable of degrading large peptides. PhTET2, which shares 24% identity with HmTET, is a cobalt-activated peptidase and possibly a deblocking aminopeptidase, assembled as a 12-subunit tetrahedral dodecamer, while PhTET1 can be alternatively assembled as a tetrahedral dodecamer or as an octahedral tetracosameric structure. The active site in such a self-compartmentalized complex is located on the inside such that substrate sizes are limited, indicating function as possible peptide scavengers. PhTET2 cleaves polypeptides by a nonprocessive mechanism, preferring N-terminal hydrophobic or uncharged polar amino acids. Streptococcus pneumoniae PepA (SpPepA) also forms dodecamer with tetrahedral architecture, and exhibits selective substrate specificity to acidic amino acids with the preference to glutamic acid, with the substrate binding S1 pocket containing an Arg allows electrostatic interactions with the N-terminal acidic residue in the substrate. The YsdC gene is conserved in a number of thermophiles, archaea and pathogenic bacterial species; the closest structural homolog is Thermotoga maritima FrwX (34% identity), which is annotated as either a cellulase or an endoglucanase, and is possibly involved in polysaccharide biosynthesis or degradation.	3.63097e-103
NC_011653.1\|WP_004103981.1\|337147_337432_-\|DUF370-domain-containing-protein	gnl\|CDD\|179823	PRK04323, PRK04323, hypothetical protein; Provisional.	4.78133e-50
NC_011653.1\|WP_012579504.1\|336513_337146_-\|guanylate-kinase	gnl\|CDD\|234719	PRK00300, gmk, guanylate kinase; Provisional.	6.4835e-111
NC_011653.1\|WP_148203261.1\|321354_322446_-\|SAVED-domain-containing-protein	gnl\|CDD\|380122	pfam18145, SAVED, SMODS-associated and fused to various effectors sensor domain. Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. The sensing of ligands by SAVED is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.	1.72652e-10
NC_011653.1\|WP_012579494.1\|319180_319903_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.14095e-33
NC_011653.1\|WP_004103969.1\|335238_336246_+\|M42-family-metallopeptidase	gnl\|CDD\|349906	cd05656, M42_Frv, M42 Peptidase, endoglucanases. Peptidase M42 family, Frv (Frv Operon Protein; Endo-1 4-Beta-Glucanase; Cellulase Protein; Endoglucanase; Endo-1 4-Beta-Glucanase Homolog; Glucanase; EC. 3.2.1.4) subfamily. Frv is a co-catalytic metallopeptidase, found in archaea and bacteria, including Pyrococcus horikoshii tetrahedral shaped phTET1 (DAPPh1; FrvX; PhDAP aminopeptidase; PhTET aminopeptidase; deblocking aminopeptidase), phTET2 (DAPPh2) and phTET3 (DAPPh3), Haloarcula marismortui TET (HmTET) as well as Bacillus subtilis YsdC. All of these exhibit aminopeptidase and deblocking activities. The HmTET is a broad substrate aminopeptidase capable of degrading large peptides. PhTET2, which shares 24% identity with HmTET, is a cobalt-activated peptidase and possibly a deblocking aminopeptidase, assembled as a 12-subunit tetrahedral dodecamer, while PhTET1 can be alternatively assembled as a tetrahedral dodecamer or as an octahedral tetracosameric structure. The active site in such a self-compartmentalized complex is located on the inside such that substrate sizes are limited, indicating function as possible peptide scavengers. PhTET2 cleaves polypeptides by a nonprocessive mechanism, preferring N-terminal hydrophobic or uncharged polar amino acids. Streptococcus pneumoniae PepA (SpPepA) also forms dodecamer with tetrahedral architecture, and exhibits selective substrate specificity to acidic amino acids with the preference to glutamic acid, with the substrate binding S1 pocket containing an Arg allows electrostatic interactions with the N-terminal acidic residue in the substrate. The YsdC gene is conserved in a number of thermophiles, archaea and pathogenic bacterial species; the closest structural homolog is Thermotoga maritima FrwX (34% identity), which is annotated as either a cellulase or an endoglucanase, and is possibly involved in polysaccharide biosynthesis or degradation.	4.22292e-129
NC_011653.1\|WP_004103961.1\|325984_326248_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.9406e-23
NC_011653.1\|WP_004103959.1\|324986_325970_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	2.47563e-125
NC_011653.1\|WP_012579495.1\|319913_321350_-\|TIGR01897-family-CRISPR-associated-protein	gnl\|CDD\|187859	cd09728, Csx1_III-U, CRISPR/Cas system-associated protein Csx1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; Some proteins could have an additional fusion with RecB-family nuclease domain; Core domain appears to have a Rossmann-like fold; loosely associated with CRISPR/Cas systems; also known as DxTHG family.	9.42446e-30
NC_011653.1\|WP_012579505.1\|337449_338325_-\|YicC-family-protein	gnl\|CDD\|236993	PRK11820, PRK11820, YicC family protein.	4.1287e-101
NC_011653.1\|WP_114702294.1\|324711_324990_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	9.72608e-24

>NC_011653.1|WP_004103963.1|326294_326672_-|hypothetical-protein
MRKFFIVLLISIFIIISFGEQNFLTTPSQVESLARVHANEDVNKFWPFLGGFVFGIIAPIYNYVVEPEVPAERLVKLRSIIKSEDDYLIDIYVRTYKDEIKKIKVGMSFAGWGSFIALLAISIST
>NC_011653.1|WP_004103961.1|325984_326248_-|CRISPR-associated-endonuclease-Cas2
MYLIMIYDVNKKRVGKVLKVARKYLKWVQNSVLEGKITKSNFETLRNQILSIIDEDEDTIYWYILEPEFVPYRKIYGNKKINVTNII
>NC_011653.1|WP_004103959.1|324986_325970_-|type-I-B-CRISPR-associated-endonuclease-Cas1
METLYIFTDGELKRKNHALYFVPKSKDSNPFFVPLKNISSIMIFSEVSFNKKFLGLLAKEGIPTFFYGYYGDFIGSFYPPENNKTGEMIVLQFQYYYDLSKRLEIAKEILESAVLNMLWVLNGYKEVTNEELNYIVKIKDSLKKQNNIPALMAIEGNIRKAYYKALGKIVKRKGFDFDERLKRPPKDEINALISFGNIILYNTVLAEIYKTSLEPRISFLHETNKRKFSLQLDIAEIFKPIIVDKAILKLVNKKEIKKEDFNFNNNGVFLYEDAKKKFINEIEERLNKKVTIYENQNVTFKTVIRHECYKLIRHLKGVEKFKGFVMG
>NC_011653.1|WP_114702294.1|324711_324990_-|CRISPR-associated-endonuclease-Cas2
MIYLKYLLLVYDVNEKRVNKIHRILKKYLVWQQNSTFEGYLSQSNIKKLFYEVKNKINEEEDSVVVYFFNSNKVFRKVIDGKDKCIFNNKFI
>NC_011653.1|WP_004103949.1|324244_324658_-|hypothetical-protein
MKQLIDAIFQKELGDFKSLIGYVYRLKEISKILGFDTLYKSRSTERERRPAIVEDNGKNSLKILFLSTKSYSRIKVDINKFCVISEDFECAELVLKSSYAFNYHKKLVFKLPRKVIEESFVKCGLCRKNIKNFIEVI
>NC_011653.1|WP_012579498.1|323567_324242_-|hypothetical-protein
MKEIILKYLNNKFEEEEENKLYLLIKKIVTIIIGTHSNYKDTLIDIYGTYDSAVNEIINEIFIKIKNKKEILMSIINNIENIESYISRMILNHIIDIVKSYKSKLSLNKEDDDGNEKIDVINIAEFDDLKSEIIAEYFVEELKSLDNMQLCYYFYKVLYNEEIFYSEKSKDAKYKMVQRLKEKLRNLVEDFGIDQKEFAIAVKIYMSEICDKIRHNNREEKNKK
>NC_011653.1|WP_012579497.1|322793_323558_-|hypothetical-protein
MSFLKKEFELYKNLFGKYKLNIESLKIVPEGKALEAGDVFVIYGDILVYGVVIEKNGDLAECVLLSQDVFLSSSKALKIKINHLVDYVYVTHVNFYIEDNFAKNYCQVIINVKEDINKIAENVEELEEQIYTGPRKEYFDLLIDQISLLYDIFFEKIFDETKEEDKIIEINIPYASEFALVAGTNSLRGENFVGIVENNTLKVYLQDNAIGKKGKLIFKNQVIYEGELPNAFVSNNIKVSVEDLKKFLVIEVID
>NC_011653.1|WP_148203261.1|321354_322446_-|SAVED-domain-containing-protein
MKSSLEKIESLVGKKLIVIFDSEFKGNSFELAVAIGSLCKKIPKNIAFTGEIDEKGNIKRNIEYLDLKMKICSENNLKLISAFDVDNLFELKEFFEAKKIHIPILISLMAKDKEYIRTSYEELKEAVNEKFEIKYSDIFEKIYDVNKVFVKDSLNDDWGQVLKEVNSLLYKIISNRGIPHIAIMGPASFSMALGIALGVQNPLVVYHKAGIEYKPVIDLTDNVRKVKNIVSDYKFVKYSVENENGKNCAFILYFASHNPYDAVKNFLSKNNIDSKLVLIEPNFGKGNLPAEDWSEIVSEIMSVTQNIQFKHSCENVFFFMSCPVPLAFGVGLSFGDFAKGSIFHFDKNTGDYIEVFKIEKIRG
>NC_011653.1|WP_012579495.1|319913_321350_-|TIGR01897-family-CRISPR-associated-protein
MKLFFSTFGKISNYKEVEYSIDYNENTFESPFLPDLMCKAFGVDTTELFLLDTLVEKNDLLKEDFKYEDIITSLENKYFNYFKSKDYKGNLNLHIIPGVGSYKEFRFVGNMNDTYYMTLIQLLNIFSRPEVINSEEIEVILDISFGINYQSNVLYRTLMDILPVLAYFKKVRFKLTNAEPVINTSAEGKNKINVYVVEEKVFEQSISYKKDFAKKTISVFRGLSINERKEVGKNYIREFEKRLRNEKNMGLNNVFLNLELYLKSIYYGLPLLYLYAMNGADFKYVVDKSLEMYNSAIEIRDSNENLKMVLRKLEFSEGIKYLVLGSIFKIYFENIYGTKYCTEIPYDELKKLSNFIWKIDEFKNQISLVLEKEIKEIESLFDYIEEGEEILFDLEMLKSRKNESIECEEKVDENTKKELEHENDELKKQNSIENFSRKERNFIAHGSLSKNTFYLKKYNSMVCIRLNEEEICKLGKAI
>NC_011653.1|WP_012579494.1|319180_319903_-|CRISPR-associated-endoribonuclease-Cas6
MRIYLDLDFEKLELPIHYNHILQSIIINMIDSSGYRKFIHDEGYVLGKRKFKLYTFSRLLGKFQIFGNKIAFFNGARLIISSLDDAMVEYIINYILKKGYINVLGEKIYVKAAVLKSLPSANYLRVSTKSPVVVYSTLFNYENKKETIFYEPDSSKFLSLVYENILKKYTAFYGSISKNNIEIKHVGKNPKRVKVVYKNTVIFGWLTAFDIYGDFELLKVAYDAGIGMKNSMGFGCVELI
>NC_011653.1|WP_012580542.1|330235_331366_-|IS3-family-transposase
MAKKGQKFKKYPSEIKYQVVKLFIEENLPKKTIASLLGIPPDRVRLWIKNYLLYGDAERKRGKPKKESFEEEMERLRAENAYLKLLMEKILEEGNSKKKIEVINELKERFSLELLCKISGISKSTYYRAMKRKDKDEKLKEEIKDIYFKYKGIYGYRRITMVLNRKGRKINHKKVYRLMKEMGLYARIRKKNHIRKLTLDAQYIADNKLKRNFKSKRPFEKFVSDITQIKTIDGKLYLIIIQDLYNNEIIEYSIGENNNLELVNNTIKRWLKSGKYRKGGILHTDRGFQYTHVLTAKILKEKGIIQSMSRKGVPQDNGPAESFFSHLKEEVVRINGEKTKEEYKKLIEEYIRFYNEERYQARLKNMAPVEYRNHVV
>NC_011653.1|WP_012579500.1|331503_331923_-|peptidylprolyl-isomerase
MGIKSGDKVKVHYVGKFEDGEVFDSSVGKEPLEFVVGMNQVIPGFEEGLMGMEVGEKRTINVPFEKAYGPYREDLVFPVEKSKLPEDVAVDHLLEVHQPDGSSFIVRVSDIKNDMAYLDANHPLAGKNLIFEVEIVSIG
>NC_011653.1|WP_012579501.1|331985_333188_-|MFS-transporter
MIKKDKQFRKFQMYGFLKNLRFFEPFLILFFLSSGLSYLQIGILYSIKSIATNILEIPTGVVADLYGRKKSMLFSMISYIVSFLIFYFSRSFYLYILAMIFFSFGEAFRTGTHKAMIFQYLKINGMENLKVQYYGATRAASQLGSALNSLIAASIVFVSGNYRTVFFIAILPYILNLINLATYPNELDKAEVKKTKKQTLKDFIDAVASWRVLKILLNTSSYSAIFKSLKDYLQPILESFALSIPIFVWLDDKKRSSIVIGIVYFFLYLLTSYASKNSWKIGKKSSSFALNLTLFVGALSVIFAGVSYIFNFYIVSILIFIVLYILENLRRPIAVSYVGDNVESDALASVLSVESQATTLLTAVFSIVLGFFADKLGVGQAVSILGIILLLMSLFFKIKD
>NC_011653.1|WP_012579502.1|333171_334122_-|radical-SAM-protein
MRYPKIIEFELTTACNYSCKHCYCNAGKKSTNELSFDEVKKVLHDLKDANVEIVDLIGGEPLIRQDIIDIISYAASIGLDVMLNTNASLASKEIVKRIKEVYPQLKVGISFDGHTPEIHDFVRGPGAFEKTYRGFLNFLEEGFDVTVLHVVNKVNYEHFEEMVKFAMEHNVSLYVDRFVPVGRGELYKDLLLPTKKEVEHVRKVIKKYENKLTFYVEENISGGLCTAGREHASVLVDGTVVPCGHFRYDKEYYMGNLKEKPFKQIWESYNPDILISNCKGCPHFSNCFGGCRAFAKKLGLDYDPIFCEVHVDDKEG
>NC_011653.1|WP_012579503.1|334221_335238_+|M20/M25/M40-family-metallo-hydrolase
MNTKDLLLKLSSIHGPSGYEHKVTKEIENIMKDLVDEYHYTKVGSLVCVKKGEGKGKIGLLAHVDQLGFVISKITDDGFAYVAGIGGWDPKTVIGQRAKIYSKNREFYGVFGFLAPHLQKAEDRKKIPTFNYLFLDISMNENWKEIQVGDIVMLDEIEGFEKNNLVYAPALDNRASCVSLIKTAEMLKKIKHQFDVYFIFSTQEEIGGPGAPTAAYFADLDYAFVIDVTHGDETIPGFRKIEINKGPVVAVGPVVDKEFNEKVQNVSSQYNIKIQYEPIPRRSGTDTDAVQLVKTGIKTQLISIPLKYMHTPYEKVHVNDVENTAKLMAFTISELEVQ
>NC_011653.1|WP_004103969.1|335238_336246_+|M42-family-metallopeptidase
MYLKELSEINGVSGNEKKVRDFIIEKIKDKVDKFWVDRMGNLIAFKKGNGKAKVVLDAHMDEVGFMITNIEEDGSLSFMPVGGVDPRVVIGKKVIINDEIIGVIGFKAIHLQDDPYKAPEFSQLKIDAGFSSKAEAEKKVKIGDYVAFTTKYKEIGNFATGKAFDDRGGCSILIDLIESNVKSDYDLYFVFSVQEETGLRGAAVVSEQIKPDFAIALETTTAGDNPELDKSQWATHIGDGPALTFLHSGYVIDKDLFDALVDTAKKNNIPFQYKRRTAGGTNAARYARSTYGVPAAVISIPSRYIHSPIIVISLDDYKNSVLLVKKFLESAPVVK
>NC_011653.1|WP_004103971.1|336302_336530_-|DNA-directed-RNA-polymerase-subunit-omega
MRPVINYDELLKKIPYKFAIPIAAAKRAENLKEFAKPYVETWDNNYVSIALKELSEGYIRIKNEEILKVLIPNVK
>NC_011653.1|WP_012579504.1|336513_337146_-|guanylate-kinase
MKGTLFVVSGPSGVGKTSIISALMNKLENIVFSVSCTTRPPRPGEVDGVDYFFVSRDKFIEMREKGEFLEWAEVHGNLYGTPKKFVLENIEKGNRIILDIDVQGALQVKRNFDDAVFIFVAPPSYEVLKERLLKRGTENSQSMLKRLENAKWEMSKIVEFDYLIVNSDLEKSILAMKSIVIAESYRTRRILDEELIKRLFKGVSESETGN
>NC_011653.1|WP_004103981.1|337147_337432_-|DUF370-domain-containing-protein
MFGLINIGFGNVIAGDRIVAIVNPESAPLKRLKEDAKEEGKLIDATYGRKTRAILISDSNHIILSAIQPETIAQRFMQSFFEIEEQLDKIRRKG
>NC_011653.1|WP_012579505.1|337449_338325_-|YicC-family-protein
MLKSMTGYAKVEKFSEKFRVSCEVKSLNSKGLDINVSLPYYLSSKEIEITKIISSFLTRGKVNVRINVKFLTPVNLSIDYVMAKSYYDTLEGVRESLGIQNSIVLGDLLNFREIFRGDIEDEVVEELWNFTKEVLSSSLEMLVEERKKEGQKICKDIENMVNKIEEITLNIEKVASDMKEEIAKKLRESVEEILPENVEMDTNQFETAVALIADKADIREEIERLKSHIDRMKELLLKDEPVGMLFNFLTQEVHREFNTILSKSRMLEISNLALEGKYINSQLKEQIQNVE

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Crispr_ID: NC_011653_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011653_4

368612-371819

Orphan

Consensus_repeat	Method
GTTTAGAATCTACCTATGAGGAATGAAAAC	PILER-CR
GTTTAGAATCTACCTATGAGGAATGAAAAC	CRISPRCasFinder
GTTTAGAATCTACCTATGAGGAATGAAAAC	CRT
GTTTAGAATCTACCTATGAGGAATGAAAAC	PILER-CR
GTTTAGAATCTACCTATGAGGAATGAAAAC	PILER-CR

45 spacers

The CRISPR arrays of NC_011653_4

>merge|NC_011653|4|368612-371819|PILER-CR,CRISPRCasFinder,CRT,PILER-CR,PILER-CR
GTTTAGAATCTACCTATGAGGAATGAAAACACAAGATCATCATCAATATCAACTTTCTTTAAGTTTAGAATCTACCTATGAGGAATGAAAACTATGCCAATTTTCATCTTTCCGCCCCCTTTTCATTCGTTTAGAATCTACCTATGAGGAATGAAAACCTCCAAGATATATTTGTTTCATTTTATCACCTCATTATAAAGTTTAGAATCTACCTATGAGGAATGAAAACCCAATTCGAGGTATTCAAAAAAATCACAATTTTTGAACTCCTCGTTTAGAATCTACCTATGAGGAATGAAAACACTAGTATTCTGAACCTTTTTGTTACTATACCTTTCATGTTTTCTCGTTTAGAATCTACCTATGAGGAATGAAAACTGAAAGAACTATTGTTCTTTTATCTAGGAGTTTTGCAAAGTTTAGAATCTACCTATGAGGAATGAAAACTAGTAGACTGTCATTCCGTCTACTTGTTCTTGATGAATATAAGAGTTTAGAATCTACCTATGAGGAATGAAAACGATTAGTGTTAAAGTGTAAATATTATTATCGCACAAATTATATGTTTAGAATCTACCTATGAGGAATGAAAACTAGAAAAGCACCACCTACAAGCAACCAAAAGCCAAATTTGTTTCCGTTTAGAATCTACCTATGAGGAATGAAAACAGCTTCCGGGTCTGAGTTGTAGTCTTGGATAAATTGTTTAGTTTAGAATCTACCTATGAGGAATGAAAACTCAATATACTTCTCTATGTTGTCGTCATTATAGTTATGTTTAGAATCTACCTATGAGGAATGAAAACTCTTTTATATTCTCTTCTAAAATTTTCATCTTTGTGTTAAGTTTAGAATCTACCTATGAGGAATGAAAACTTTGCAAAGAGATCGCCAGCATCTCCAAAGCTGGCAACCACGACCCGTTTAGAATCTACCTATGAGGAATGAAAACATATATTGTAGTAATGGAAACACAGATTGTCCTTCAAAAAACGATAGTTTAGAATCTACCTATGAGGAATGAAAACTGTGTCATACAATCTGGAAACCATCACATACATAATTACACGTTTAGAATCTACCTATGAGGAATGAAAACGAAACCATCACATACATAATCACACCATCCTTTCTTTTGGTTTAGAATCTACCTATGAGGAATGAAAACCGGATTGTCGCAGAACAAAAGTGTTGGTAAAGTAATGTTTAGAATCTACCTATGAGGAATGAAAACTTTTGAATCTCTTTGTCAGTTTACCTTTCATGTTTTCTGTTTAGAATCTACCTATGAGGAATGAAAACACCATAATACCCCTCCTTATTTTATTTTTTCGGAACCTTTTAGTTTAGAATCTACCTATGAGGAATGAAAACATACTTGCATCTCTCTGTTTCGATTGTTACTTGTAAATAATATGTTTAGAATCTACCTATGAGGAATGAAAACGGCTCATTTTTGTGTTACGCAACGAAAATGTAGTTGTCACCGTTTAGAATCTACCTATGAGGAATGAAAACCACTCAGCCTCCGGGTCTGTGTTGTAATCTTGAATAAATTTTGTTTAGAATCTACCTATGAGGAATGAAAACGAATTCAATTGTTTTGTTTCCAATTTTTGCAAAGAGATCGCGTTTAGAATCTACCTATGAGGAATGAAAACCATTTATTTCATGGCATATTTTCGATGAAATATATAACAGTTTAGAATCTACCTATGAGGAATGAAAACCATTATATATGTGTGAAATATGCTGAGCGTTACCATTAATTCCGTTTAGAATCTACCTATGAGGAATGAAAACTCCAAGTTCGAGGTCTTCAAAATCTCTGAATTCCTTGAACTCCGTTTAGAATCTACCTATGAGGAATGAAAACAAGTTTTCTTGTGGTCTACAAATAATTTCAAGCTTCATACTTCGTTTAGAATCTACCTATGAGGAATGAAAACGCAACTTTGATTCCAAATTCCAAGTATTCAAAATAGTTACAATTGTTTAGAATCTACCTATGAGGAATGAAAACTTTTTGTTCCATCCTTATGTAAAATTTCATACTTCGTTTAGAATCTACCTATGAGGAATGAAAACAAAAAAAGCGGTGGGTCAAAACCCACCGCTTATTAAAAAGTTTAGAATCTACCTATGAGGAATGAAAACTTCTCTTCTTCTTCTTGCCTTGTCAACATATCTAATTTTTCTTGTTTAGAATCTACCTATGAGGAATGAAAACAGTCTTGCATGGCTTTTCGCAATTGTTCTACGACGTTTAGAATCTACCTATGAGGAATGAAAACTAAGCTGAATAAGCCTACTTTTGTCATTGTCCTATTGTTTAGAATCTACCTATGAGGAATGAAAACTTATTCCATAGTCTTCCGATACTGTATCGATACTGTATCGTTTAGAATCTACCTATGAGGAATGAAAACCTGCATTCTGTACTAAACCTATAAGTTCAAAAATAGACGTGTTTAGAATCTACCTATGAGGAATGAAAACAACTGTTTTCGCGATTAACTTTGACCTCTCATCAGACGGTTTAGAATCTACCTATGAGGAATGAAAACGCCAGAACTAAGTTTTTGACGTTCTCCCAGGGAGCCAACCATGTTTAGAATCTACCTATGAGGAATGAAAACACTTTATAAGATTCATAAATCTTTTTACTCATAATTTCTCCTCGTTTAGAATCTACCTATGAGGAATGAAAACGAGGTACTCCTATAGTGATTCCAAGAAGAGGCAAAACAACAGTTTAGAATCTACCTATGAGGAATGAAAACACTAGCAAAGCCAAAACGCCAGTCGAAATTTAGAAAAAGTTTAGAATCTACCTATGAGGAATGAAAACGAGGTACTCCTATAGTGATTCCAAGAAGAGGCAAAACAACAGTTTAGAATCTACCTATGAGGAATGAAAACACTAGCAAAGCCAAAACGCCAGTCGAAATTTAGAAAAAGTTTAGAATCTACCTATGAGGAATGAAAACTTGGTCGGATCCAAAACAAAAATCTTTCCCTTTCGACATTTTTTTGTTTAGAATCTACCTATGAGGAATGAAAACTCATCATCTGCGATTATCGCTAGAACTAAATTCCTTATGCACTGTTTAGAATCTACCTATGAGGAATGAAAACGTCATCATCTGCGATTATTGCCAAAACTAGGTTCTGGATAGTTTAGAATCTACCTATGAGGAATGAAAAC

>NC_011653|4|5|368612-370487|PILER-CR
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACAAGATCATCATCAATATCAACTTTCTTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TATGCCAATTTTCATCTTTCCGCCCCCTTTTCATTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTCCAAGATATATTTGTTTCATTTTATCACCTCATTATAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CCAATTCGAGGTATTCAAAAAAATCACAATTTTTGAACTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGTATTCTGAACCTTTTTGTTACTATACCTTTCATGTTTTCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGAAAGAACTATTGTTCTTTTATCTAGGAGTTTTGCAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAGTAGACTGTCATTCCGTCTACTTGTTCTTGATGAATATAAGA
GTTTAGAATCTACCTATGAGGAATGAAAAC	GATTAGTGTTAAAGTGTAAATATTATTATCGCACAAATTATAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAGAAAAGCACCACCTACAAGCAACCAAAAGCCAAATTTGTTTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AGCTTCCGGGTCTGAGTTGTAGTCTTGGATAAATTGTTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCAATATACTTCTCTATGTTGTCGTCATTATAGTTAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCTTTTATATTCTCTTCTAAAATTTTCATCTTTGTGTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTGCAAAGAGATCGCCAGCATCTCCAAAGCTGGCAACCACGACCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATATATTGTAGTAATGGAAACACAGATTGTCCTTCAAAAAACGATA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGTGTCATACAATCTGGAAACCATCACATACATAATTACAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAAACCATCACATACATAATCACACCATCCTTTCTTTTG
GTTTAGAATCTACCTATGAGGAATGAAAAC	CGGATTGTCGCAGAACAAAAGTGTTGGTAAAGTAAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTGAATCTCTTTGTCAGTTTACCTTTCATGTTTTCT
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACCATAATACCCCTCCTTATTTTATTTTTTCGGAACCTTTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATACTTGCATCTCTCTGTTTCGATTGTTACTTGTAAATAATAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GGCTCATTTTTGTGTTACGCAACGAAAATGTAGTTGTCACC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CACTCAGCCTCCGGGTCTGTGTTGTAATCTTGAATAAATTTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAATTCAATTGTTTTGTTTCCAATTTTTGCAAAGAGATCGC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATTTATTTCATGGCATATTTTCGATGAAATATATAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATTATATATGTGTGAAATATGCTGAGCGTTACCATTAATTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCCAAGTTCGAGGTCTTCAAAATCTCTGAATTCCTTGAACTCC
GTTTAGAATCTACCTATGAGGAATGAAAACAAGTTTTCTTGTGGTCTACAAATAATTTCAAGCTTCATACTTCGTTTAGAATCTACCTATGAGGAATGAAAACGCAACTTTGATTCCAAATTCCAAGTATTCAAAATAGTTACAATTGTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTTGTTCCATCCTTATGTAAAATTTCATACTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AAAAAAAGCGGTGGGTCAAAACCCACCGCTTATTAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTCTCTTCTTCTTCTTGCCTTGTCAACATATCTAATTTTTCTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	AGTCTTGCATGGCTTTTCGCAATTGTTCTACGAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAAGCTGAATAAGCCTACTTTTGTCATTGTCCTATT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTATTCCATAGTCTTCCGATACTGTATCGATACTGTATC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTGCATTCTGTACTAAACCTATAAGTTCAAAAATAGACGT
GTTTAGAATCTACCTATGAGGAATGAAAACAACTGTTTTCGCGATTAACTTTGACCTCTCATCAGACGGTTTAGAATCTACCTATGAGGAATGAAAAC	GCCAGAACTAAGTTTTTGACGTTCTCCCAGGGAGCCAACCAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTTTATAAGATTCATAAATCTTTTTACTCATAATTTCTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAGGTACTCCTATAGTGATTCCAAGAAGAGGCAAAACAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGCAAAGCCAAAACGCCAGTCGAAATTTAGAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAGGTACTCCTATAGTGATTCCAAGAAGAGGCAAAACAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGCAAAGCCAAAACGCCAGTCGAAATTTAGAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTGGTCGGATCCAAAACAAAAATCTTTCCCTTTCGACATTTTTTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCATCATCTGCGATTATCGCTAGAACTAAATTCCTTATGCACT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTCATCATCTGCGATTATTGCCAAAACTAGGTTCTGGATA


>NC_011653|4|4|368612-371819|CRISPRCasFinder
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACAAGATCATCATCAATATCAACTTTCTTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TATGCCAATTTTCATCTTTCCGCCCCCTTTTCATTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTCCAAGATATATTTGTTTCATTTTATCACCTCATTATAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CCAATTCGAGGTATTCAAAAAAATCACAATTTTTGAACTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGTATTCTGAACCTTTTTGTTACTATACCTTTCATGTTTTCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGAAAGAACTATTGTTCTTTTATCTAGGAGTTTTGCAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAGTAGACTGTCATTCCGTCTACTTGTTCTTGATGAATATAAGA
GTTTAGAATCTACCTATGAGGAATGAAAAC	GATTAGTGTTAAAGTGTAAATATTATTATCGCACAAATTATAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAGAAAAGCACCACCTACAAGCAACCAAAAGCCAAATTTGTTTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AGCTTCCGGGTCTGAGTTGTAGTCTTGGATAAATTGTTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCAATATACTTCTCTATGTTGTCGTCATTATAGTTAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCTTTTATATTCTCTTCTAAAATTTTCATCTTTGTGTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTGCAAAGAGATCGCCAGCATCTCCAAAGCTGGCAACCACGACCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATATATTGTAGTAATGGAAACACAGATTGTCCTTCAAAAAACGATA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGTGTCATACAATCTGGAAACCATCACATACATAATTACAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAAACCATCACATACATAATCACACCATCCTTTCTTTTG
GTTTAGAATCTACCTATGAGGAATGAAAAC	CGGATTGTCGCAGAACAAAAGTGTTGGTAAAGTAAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTGAATCTCTTTGTCAGTTTACCTTTCATGTTTTCT
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACCATAATACCCCTCCTTATTTTATTTTTTCGGAACCTTTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATACTTGCATCTCTCTGTTTCGATTGTTACTTGTAAATAATAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GGCTCATTTTTGTGTTACGCAACGAAAATGTAGTTGTCACC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CACTCAGCCTCCGGGTCTGTGTTGTAATCTTGAATAAATTTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAATTCAATTGTTTTGTTTCCAATTTTTGCAAAGAGATCGC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATTTATTTCATGGCATATTTTCGATGAAATATATAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATTATATATGTGTGAAATATGCTGAGCGTTACCATTAATTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCCAAGTTCGAGGTCTTCAAAATCTCTGAATTCCTTGAACTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AAGTTTTCTTGTGGTCTACAAATAATTTCAAGCTTCATACTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GCAACTTTGATTCCAAATTCCAAGTATTCAAAATAGTTACAATT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTTGTTCCATCCTTATGTAAAATTTCATACTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AAAAAAAGCGGTGGGTCAAAACCCACCGCTTATTAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTCTCTTCTTCTTCTTGCCTTGTCAACATATCTAATTTTTCTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	AGTCTTGCATGGCTTTTCGCAATTGTTCTACGAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAAGCTGAATAAGCCTACTTTTGTCATTGTCCTATT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTATTCCATAGTCTTCCGATACTGTATCGATACTGTATC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTGCATTCTGTACTAAACCTATAAGTTCAAAAATAGACGT
GTTTAGAATCTACCTATGAGGAATGAAAAC	AACTGTTTTCGCGATTAACTTTGACCTCTCATCAGACG
GTTTAGAATCTACCTATGAGGAATGAAAAC	GCCAGAACTAAGTTTTTGACGTTCTCCCAGGGAGCCAACCAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTTTATAAGATTCATAAATCTTTTTACTCATAATTTCTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAGGTACTCCTATAGTGATTCCAAGAAGAGGCAAAACAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGCAAAGCCAAAACGCCAGTCGAAATTTAGAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAGGTACTCCTATAGTGATTCCAAGAAGAGGCAAAACAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGCAAAGCCAAAACGCCAGTCGAAATTTAGAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTGGTCGGATCCAAAACAAAAATCTTTCCCTTTCGACATTTTTTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCATCATCTGCGATTATCGCTAGAACTAAATTCCTTATGCACT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTCATCATCTGCGATTATTGCCAAAACTAGGTTCTGGATA
GTTTAGAATCTACCTATGAGGAATGAAAAC

>NC_011653|4|4|368612-371819|CRT
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACAAGATCATCATCAATATCAACTTTCTTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TATGCCAATTTTCATCTTTCCGCCCCCTTTTCATTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTCCAAGATATATTTGTTTCATTTTATCACCTCATTATAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CCAATTCGAGGTATTCAAAAAAATCACAATTTTTGAACTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGTATTCTGAACCTTTTTGTTACTATACCTTTCATGTTTTCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGAAAGAACTATTGTTCTTTTATCTAGGAGTTTTGCAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAGTAGACTGTCATTCCGTCTACTTGTTCTTGATGAATATAAGA
GTTTAGAATCTACCTATGAGGAATGAAAAC	GATTAGTGTTAAAGTGTAAATATTATTATCGCACAAATTATAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAGAAAAGCACCACCTACAAGCAACCAAAAGCCAAATTTGTTTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AGCTTCCGGGTCTGAGTTGTAGTCTTGGATAAATTGTTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCAATATACTTCTCTATGTTGTCGTCATTATAGTTAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCTTTTATATTCTCTTCTAAAATTTTCATCTTTGTGTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTGCAAAGAGATCGCCAGCATCTCCAAAGCTGGCAACCACGACCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATATATTGTAGTAATGGAAACACAGATTGTCCTTCAAAAAACGATA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGTGTCATACAATCTGGAAACCATCACATACATAATTACAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAAACCATCACATACATAATCACACCATCCTTTCTTTTG
GTTTAGAATCTACCTATGAGGAATGAAAAC	CGGATTGTCGCAGAACAAAAGTGTTGGTAAAGTAAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTGAATCTCTTTGTCAGTTTACCTTTCATGTTTTCT
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACCATAATACCCCTCCTTATTTTATTTTTTCGGAACCTTTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATACTTGCATCTCTCTGTTTCGATTGTTACTTGTAAATAATAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GGCTCATTTTTGTGTTACGCAACGAAAATGTAGTTGTCACC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CACTCAGCCTCCGGGTCTGTGTTGTAATCTTGAATAAATTTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAATTCAATTGTTTTGTTTCCAATTTTTGCAAAGAGATCGC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATTTATTTCATGGCATATTTTCGATGAAATATATAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATTATATATGTGTGAAATATGCTGAGCGTTACCATTAATTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCCAAGTTCGAGGTCTTCAAAATCTCTGAATTCCTTGAACTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AAGTTTTCTTGTGGTCTACAAATAATTTCAAGCTTCATACTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GCAACTTTGATTCCAAATTCCAAGTATTCAAAATAGTTACAATT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTTGTTCCATCCTTATGTAAAATTTCATACTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AAAAAAAGCGGTGGGTCAAAACCCACCGCTTATTAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTCTCTTCTTCTTCTTGCCTTGTCAACATATCTAATTTTTCTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	AGTCTTGCATGGCTTTTCGCAATTGTTCTACGAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAAGCTGAATAAGCCTACTTTTGTCATTGTCCTATT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTATTCCATAGTCTTCCGATACTGTATCGATACTGTATC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTGCATTCTGTACTAAACCTATAAGTTCAAAAATAGACGT
GTTTAGAATCTACCTATGAGGAATGAAAAC	AACTGTTTTCGCGATTAACTTTGACCTCTCATCAGACG
GTTTAGAATCTACCTATGAGGAATGAAAAC	GCCAGAACTAAGTTTTTGACGTTCTCCCAGGGAGCCAACCAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTTTATAAGATTCATAAATCTTTTTACTCATAATTTCTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAGGTACTCCTATAGTGATTCCAAGAAGAGGCAAAACAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGCAAAGCCAAAACGCCAGTCGAAATTTAGAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAGGTACTCCTATAGTGATTCCAAGAAGAGGCAAAACAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGCAAAGCCAAAACGCCAGTCGAAATTTAGAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTGGTCGGATCCAAAACAAAAATCTTTCCCTTTCGACATTTTTTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCATCATCTGCGATTATCGCTAGAACTAAATTCCTTATGCACT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTCATCATCTGCGATTATTGCCAAAACTAGGTTCTGGATA
GTTTAGAATCTACCTATGAGGAATGAAAAC

>NC_011653|4|6|370605-371110|PILER-CR
	ACAAGATCATCATCAATATCAACTTTCTTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TATGCCAATTTTCATCTTTCCGCCCCCTTTTCATTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTCCAAGATATATTTGTTTCATTTTATCACCTCATTATAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CCAATTCGAGGTATTCAAAAAAATCACAATTTTTGAACTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGTATTCTGAACCTTTTTGTTACTATACCTTTCATGTTTTCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGAAAGAACTATTGTTCTTTTATCTAGGAGTTTTGCAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAGTAGACTGTCATTCCGTCTACTTGTTCTTGATGAATATAAGA
GTTTAGAATCTACCTATGAGGAATGAAAAC	GATTAGTGTTAAAGTGTAAATATTATTATCGCACAAATTATAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAGAAAAGCACCACCTACAAGCAACCAAAAGCCAAATTTGTTTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AGCTTCCGGGTCTGAGTTGTAGTCTTGGATAAATTGTTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCAATATACTTCTCTATGTTGTCGTCATTATAGTTAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCTTTTATATTCTCTTCTAAAATTTTCATCTTTGTGTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTGCAAAGAGATCGCCAGCATCTCCAAAGCTGGCAACCACGACCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATATATTGTAGTAATGGAAACACAGATTGTCCTTCAAAAAACGATA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGTGTCATACAATCTGGAAACCATCACATACATAATTACAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAAACCATCACATACATAATCACACCATCCTTTCTTTTG
GTTTAGAATCTACCTATGAGGAATGAAAAC	CGGATTGTCGCAGAACAAAAGTGTTGGTAAAGTAAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTGAATCTCTTTGTCAGTTTACCTTTCATGTTTTCT
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACCATAATACCCCTCCTTATTTTATTTTTTCGGAACCTTTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATACTTGCATCTCTCTGTTTCGATTGTTACTTGTAAATAATAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GGCTCATTTTTGTGTTACGCAACGAAAATGTAGTTGTCACC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CACTCAGCCTCCGGGTCTGTGTTGTAATCTTGAATAAATTTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAATTCAATTGTTTTGTTTCCAATTTTTGCAAAGAGATCGC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATTTATTTCATGGCATATTTTCGATGAAATATATAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATTATATATGTGTGAAATATGCTGAGCGTTACCATTAATTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCCAAGTTCGAGGTCTTCAAAATCTCTGAATTCCTTGAACTCC
GTTTAGAATCTACCTATGAGGAATGAAAACAAGTTTTCTTGTGGTCTACAAATAATTTCAAGCTTCATACTTCGTTTAGAATCTACCTATGAGGAATGAAAACGCAACTTTGATTCCAAATTCCAAGTATTCAAAATAGTTACAATTGTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTTGTTCCATCCTTATGTAAAATTTCATACTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AAAAAAAGCGGTGGGTCAAAACCCACCGCTTATTAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTCTCTTCTTCTTCTTGCCTTGTCAACATATCTAATTTTTCTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	AGTCTTGCATGGCTTTTCGCAATTGTTCTACGAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAAGCTGAATAAGCCTACTTTTGTCATTGTCCTATT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTATTCCATAGTCTTCCGATACTGTATCGATACTGTATC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTGCATTCTGTACTAAACCTATAAGTTCAAAAATAGACGT
GTTTAGAATCTACCTATGAGGAATGAAAACAACTGTTTTCGCGATTAACTTTGACCTCTCATCAGACGGTTTAGAATCTACCTATGAGGAATGAAAAC	GCCAGAACTAAGTTTTTGACGTTCTCCCAGGGAGCCAACCAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTTTATAAGATTCATAAATCTTTTTACTCATAATTTCTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAGGTACTCCTATAGTGATTCCAAGAAGAGGCAAAACAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGCAAAGCCAAAACGCCAGTCGAAATTTAGAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAGGTACTCCTATAGTGATTCCAAGAAGAGGCAAAACAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGCAAAGCCAAAACGCCAGTCGAAATTTAGAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTGGTCGGATCCAAAACAAAAATCTTTCCCTTTCGACATTTTTTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCATCATCTGCGATTATCGCTAGAACTAAATTCCTTATGCACT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTCATCATCTGCGATTATTGCCAAAACTAGGTTCTGGATA


>NC_011653|4|7|371149-371819|PILER-CR
	ACAAGATCATCATCAATATCAACTTTCTTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TATGCCAATTTTCATCTTTCCGCCCCCTTTTCATTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTCCAAGATATATTTGTTTCATTTTATCACCTCATTATAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CCAATTCGAGGTATTCAAAAAAATCACAATTTTTGAACTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGTATTCTGAACCTTTTTGTTACTATACCTTTCATGTTTTCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGAAAGAACTATTGTTCTTTTATCTAGGAGTTTTGCAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAGTAGACTGTCATTCCGTCTACTTGTTCTTGATGAATATAAGA
GTTTAGAATCTACCTATGAGGAATGAAAAC	GATTAGTGTTAAAGTGTAAATATTATTATCGCACAAATTATAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAGAAAAGCACCACCTACAAGCAACCAAAAGCCAAATTTGTTTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AGCTTCCGGGTCTGAGTTGTAGTCTTGGATAAATTGTTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCAATATACTTCTCTATGTTGTCGTCATTATAGTTAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCTTTTATATTCTCTTCTAAAATTTTCATCTTTGTGTTAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTGCAAAGAGATCGCCAGCATCTCCAAAGCTGGCAACCACGACCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATATATTGTAGTAATGGAAACACAGATTGTCCTTCAAAAAACGATA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TGTGTCATACAATCTGGAAACCATCACATACATAATTACAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAAACCATCACATACATAATCACACCATCCTTTCTTTTG
GTTTAGAATCTACCTATGAGGAATGAAAAC	CGGATTGTCGCAGAACAAAAGTGTTGGTAAAGTAAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTGAATCTCTTTGTCAGTTTACCTTTCATGTTTTCT
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACCATAATACCCCTCCTTATTTTATTTTTTCGGAACCTTTTA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ATACTTGCATCTCTCTGTTTCGATTGTTACTTGTAAATAATAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GGCTCATTTTTGTGTTACGCAACGAAAATGTAGTTGTCACC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CACTCAGCCTCCGGGTCTGTGTTGTAATCTTGAATAAATTTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAATTCAATTGTTTTGTTTCCAATTTTTGCAAAGAGATCGC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATTTATTTCATGGCATATTTTCGATGAAATATATAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	CATTATATATGTGTGAAATATGCTGAGCGTTACCATTAATTCC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCCAAGTTCGAGGTCTTCAAAATCTCTGAATTCCTTGAACTCC
GTTTAGAATCTACCTATGAGGAATGAAAACAAGTTTTCTTGTGGTCTACAAATAATTTCAAGCTTCATACTTCGTTTAGAATCTACCTATGAGGAATGAAAACGCAACTTTGATTCCAAATTCCAAGTATTCAAAATAGTTACAATTGTTTAGAATCTACCTATGAGGAATGAAAAC	TTTTTGTTCCATCCTTATGTAAAATTTCATACTTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	AAAAAAAGCGGTGGGTCAAAACCCACCGCTTATTAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTCTCTTCTTCTTCTTGCCTTGTCAACATATCTAATTTTTCTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	AGTCTTGCATGGCTTTTCGCAATTGTTCTACGAC
GTTTAGAATCTACCTATGAGGAATGAAAAC	TAAGCTGAATAAGCCTACTTTTGTCATTGTCCTATT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTATTCCATAGTCTTCCGATACTGTATCGATACTGTATC
GTTTAGAATCTACCTATGAGGAATGAAAAC	CTGCATTCTGTACTAAACCTATAAGTTCAAAAATAGACGT
GTTTAGAATCTACCTATGAGGAATGAAAACAACTGTTTTCGCGATTAACTTTGACCTCTCATCAGACGGTTTAGAATCTACCTATGAGGAATGAAAAC	GCCAGAACTAAGTTTTTGACGTTCTCCCAGGGAGCCAACCAT
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTTTATAAGATTCATAAATCTTTTTACTCATAATTTCTCCTC
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAGGTACTCCTATAGTGATTCCAAGAAGAGGCAAAACAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGCAAAGCCAAAACGCCAGTCGAAATTTAGAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	GAGGTACTCCTATAGTGATTCCAAGAAGAGGCAAAACAACA
GTTTAGAATCTACCTATGAGGAATGAAAAC	ACTAGCAAAGCCAAAACGCCAGTCGAAATTTAGAAAAA
GTTTAGAATCTACCTATGAGGAATGAAAAC	TTGGTCGGATCCAAAACAAAAATCTTTCCCTTTCGACATTTTTTT
GTTTAGAATCTACCTATGAGGAATGAAAAC	TCATCATCTGCGATTATCGCTAGAACTAAATTCCTTATGCACT
GTTTAGAATCTACCTATGAGGAATGAAAAC	GTCATCATCTGCGATTATTGCCAAAACTAGGTTCTGGATA
GTTTAGAATCTACCTATGAGGAATGAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011653.1\|WP_012579529.1\|375071_376925_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_011653.1\|WP_081429687.1\|383130_383469_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213362
NC_011653.1\|WP_012579530.1\|376921_378646_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_011653.1\|WP_012579528.1\|372477_374664_-\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NC_011653.1\|WP_012579522.1\|361655_364031_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_004104037.1\|355113_355377_+\|stage-V-sporulation-protein-S	unknown	unknown	gnl\|CDD\|377254
NC_011653.1\|WP_012579525.1\|365299_366469_-\|tRNA-4-thiouridine(8)-synthase-ThiI	unknown	unknown	gnl\|CDD\|234960
NC_011653.1\|WP_012579531.1\|378629_379082_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_011653.1\|WP_004104061.1\|372000_372207_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328
NC_011653.1\|WP_012579523.1\|364030_364561_-\|bifunctional-nuclease-family-protein	unknown	unknown	gnl\|CDD\|376830
NC_011653.1\|WP_004104067.1\|374676_374949_-\|metal-sensing-transcriptional-repressor	unknown	unknown	gnl\|CDD\|197394
NC_011653.1\|WP_012579526.1\|366653_367430_+\|FTR1-family-protein	unknown	unknown	gnl\|CDD\|272930
NC_011653.1\|WP_148203262.1\|358754_360827_-\|fibronectin-type-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|379868
NC_011653.1\|WP_004104076.1\|382438_382780_+\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012579532.1\|379190_380405_-\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341465
NC_011653.1\|WP_004104063.1\|372222_372465_-\|SHOCT-domain-containing-protein	unknown	unknown	gnl\|CDD\|225993
NC_011653.1\|WP_012579521.1\|361031_361643_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012579524.1\|364541_365303_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NC_011653.1\|WP_012579519.1\|357020_358748_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_011653.1\|WP_012579518.1\|355439_356993_-\|bifunctional-UDP-sugar-hydrolase/5'-nucleotidase	unknown	unknown	gnl\|CDD\|236566

Protein	Function_ID	Function_description	E-value
NC_011653.1\|WP_081429687.1\|383130_383469_+\|hypothetical-protein	gnl\|CDD\|213362	cd12828, TmCorA-like_1, Thermotoga maritima CorA_like subfamily. This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.91243e-32
NC_011653.1\|WP_012579530.1\|376921_378646_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.47472e-169
NC_011653.1\|WP_012579528.1\|372477_374664_-\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_011653.1\|WP_012579518.1\|355439_356993_-\|bifunctional-UDP-sugar-hydrolase/5'-nucleotidase	gnl\|CDD\|236566	PRK09558, ushA, bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed.	0
NC_011653.1\|WP_004104037.1\|355113_355377_+\|stage-V-sporulation-protein-S	gnl\|CDD\|377254	pfam04232, SpoVS, Stage V sporulation protein S (SpoVS). In Bacillus subtilis this protein interferes with sporulation at an early stage and this inhibitory effect is overcome by SpoIIB and SpoVG. SpoVS seems to play a positive role in allowing progression beyond stage V of sporulation. Null mutations in the spoVS gene block sporulation at stage V, impairing the development of heat resistance and coat assembly.	1.96516e-45
NC_011653.1\|WP_012579525.1\|365299_366469_-\|tRNA-4-thiouridine(8)-synthase-ThiI	gnl\|CDD\|234960	PRK01565, PRK01565, thiamine biosynthesis protein ThiI; Provisional.	0
NC_011653.1\|WP_012579531.1\|378629_379082_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.94542e-22
NC_011653.1\|WP_004104061.1\|372000_372207_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	2.69789e-09
NC_011653.1\|WP_012579523.1\|364030_364561_-\|bifunctional-nuclease-family-protein	gnl\|CDD\|376830	pfam02577, DNase-RNase, Bifunctional nuclease. This family is a bifunctional nuclease, with both DNase and RNase activity. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site.	2.2891e-50
NC_011653.1\|WP_004104067.1\|374676_374949_-\|metal-sensing-transcriptional-repressor	gnl\|CDD\|197394	cd10159, CsoR-like_DUF156_2, Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156. Uncharacterized family 2, belonging to a larger superfamily that contains various transcriptional regulators that respond to different stressors such as Cu(I), Ni(I), sulfite, and formaldehyde, and includes CsoRs (copper-sensitive operon repressors). CsoRs form homotetramers (dimer of dimers). In Mycobacterium tuberculosis CsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily, including this family, and a conserved Tyr and a Glu residue that facilitate allosteric regulation of DNA binding for CsoRs are also conserved.	6.19928e-37
NC_011653.1\|WP_012579526.1\|366653_367430_+\|FTR1-family-protein	gnl\|CDD\|272930	TIGR00145, Uncharacterized_protein_slr0964, FTR1 family protein. A characterized member from yeast acts as oxidase-coupled high affinity iron transporter. Note that the apparent member from E. coli K12-MG1655 has a frameshift by homology with member sequences from other species. [Unknown function, General].	2.49281e-37
NC_011653.1\|WP_148203262.1\|358754_360827_-\|fibronectin-type-III-domain-containing-protein	gnl\|CDD\|379868	pfam16656, Pur_ac_phosph_N, Purple acid Phosphatase, N-terminal domain. This domain is found at the N-terminus of Purple acid phosphatase proteins.	0.0010514
NC_011653.1\|WP_012579532.1\|379190_380405_-\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341465	cd08186, Fe-ADH-like, Iron-containing alcohol dehydrogenase. This family contains iron-containing alcohol dehydrogenase (ADH) which catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. The ADH of hyperthermophilic archaeon Thermococcus hydrothermalis oxidizes a series of primary aliphatic and aromatic alcohols, preferentially from C2 to C8, but is also active towards methanol and glycerol, and is stereospecific for monoterpenes. It has been suggested that the type III ADHs in microorganisms are involved in acetaldehyde detoxication rather than in alcohol turnover.	0
NC_011653.1\|WP_012579529.1\|375071_376925_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NC_011653.1\|WP_012579524.1\|364541_365303_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	2.84732e-49
NC_011653.1\|WP_012579519.1\|357020_358748_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	7.37969e-158
NC_011653.1\|WP_004104063.1\|372222_372465_-\|SHOCT-domain-containing-protein	gnl\|CDD\|225993	COG3462, COG3462, Predicted membrane protein [Function unknown].	5.2995e-10

>NC_011653.1|WP_012579526.1|366653_367430_+|FTR1-family-protein
MASFIITFREALEAVLIVSIIFAFLNKNKLPNYKKHVYLGITLGIVSSIIFGMILATLEEHFAEAFEGIFSLIGAFLITTLILWLHKNKNFNKEIQNKLNSSLNKNFGITLILLVTVNILREGFETVIFLSAIPGDASIIYAILGIVVALVLGYLLYIGILKVNISIFFTVTNVLLILFAAGLIAYGIHELQEAGWFPIIIEHIYDINSFINEKGTFGGFLKTLFGYNGNPSLIEFIAYWTYLIPSMFFAFRKKEIKK
>NC_011653.1|WP_012579525.1|365299_366469_-|tRNA-4-thiouridine(8)-synthase-ThiI
MEPVVVVRYSEIGLKGKNRGYFEKKLIDNIRKIARPPEINKRYGRIIIRLKDMDFDEIKERLKYVFGIQNFSFAYAVSHDLDKIKEVVLKLLKLKLKNEKTFKVQTKRSYKQFPMNSQELSAHIGAFVLENFKELSVDVHNPDIIVGIEVKEKEVFVFVGKEQMYGGFPVGSSGKGILLLSGGIDSPVAGWYMMKRGILIETLSFLSPPFTSEKSKNKILELSNILSKYVPDTLKTWIVPFTPVQQYIKTNAPDKYSLIIQRRSMMRIANKLAKKIKAKAIITGENVGQVASQTLENLHTIESASNLPVLRPLIGFEKIDIVEKAKEIGSYEISIQPYLDSCVVFAPKNPATKSSIKEIEEIESKLTELSNLEEKAFENIEKHVIGRKL
>NC_011653.1|WP_012579524.1|364541_365303_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MRKIGSFFYTLYFLIGAVIYIVFYGAIVLFIGFLIGLFNKNLSRRFVVGQIETFGRMAFKLLGIKVYVYGEKPEIGENYLVVANHQSALDIPLIIGYVAPVAFIAKKELGKVPGINWFLKYLGSVLIERGNIRKTAMALKEVVKKLNDGVHFILFPEGTRSPDGSILPFKNRSLEISYKYKVKILPVSIWGAHEVLPKKSLIIRRKPIYIKIHELVDPNQFDSEEELREYVRNVIIEGVKFLEGRNLNEKSNS
>NC_011653.1|WP_012579523.1|364030_364561_-|bifunctional-nuclease-family-protein
MKKATVKAVVLDKLNNAPVVILGIEGTNKILPIWIGACEASVLALMLENADFERPLTHDLMINIIEGLEAKVERVYINKIENNTFFARVILKDLTIPEEEEEGHYIEFDARPSDAIILALKTSSPIYVSNELVNTHTVNFEGEKFDDEDEEFKKFVENLDIEEFKRRFKKGSQGDN
>NC_011653.1|WP_012579522.1|361655_364031_-|hypothetical-protein
MGFLKKILEKISPFFTMLKEKLKLNKVIEFLKSFYKRKVLFILTISIVVIAVALSILLSRILGKNAIEINPNQEITIIENLHVNIPKGAFPYEKKFNLIPLTKDSNPGIFSSAPFIDVVYDVKAADGKTDFSYVPMTFRYYFPAKYFLGIDYNNVALAYIPDDGSAFRVFPGCYIGYDEKGYFVEAKSFHSSKIGVVALTPKKQELGIKVLVEKLSPEPAILIVPGTDRNFKGYFKSDESSDLNFWSVAFSNRTIMLYNYPLYEVRSKLYQDMVTDYFKRSELKSYIEFEAERLASELKRFKNFKFDIVAQDIGGLIVTYTLLLHPEIDNIRRIAFVSVPFKGTNISNPVYFASLLYGKNPSALSKVYNLDENIVSSVQTHIFTYLETVNTYWNEILPNSQLLKKFENFKFPDSVKVVSFMGTRPPLGIDITGSGLAKFYPELIKGQGDGIVSTDSATLEGVQLVQIDGDAYTFYSKSEFIEKLKEFFTFDEIKVPEYKDDTYREYVSQTEKEKEVYLSKLIPYRFSGATISDSIVVEPEEKLDYPGNQIAIYKSVVYTGGPDGLFANGTKLMDGPILNLKETFDGVSFRMANEIYFYSPAIKKKYNIVYVSDFLATAEGVYTAVQAGEMISFWDPRGNKIVDLKGQYGRIKVDNNYLIFYTNKQIYVPKLELLLNVPQLENKSIDISDAIIYKNEVLSVTRSYGFLFFDIGTTEGNYVGEGWIGNIKIHHVANYFLTIGKNFITIVDIPERRVLKIIEKLDFDVINSATDGKYLYLVSKDGIYKYKVREY
>NC_011653.1|WP_012579521.1|361031_361643_-|hypothetical-protein
MIHLFLGHYVADHGFTHNSKLRHLKGWKLIEHLIWSVFAILAFTFDTLLKDAPVILFTFIAIHLVLDFLRTKVKKESFYHLIEISGIILALIFNYSVYKYFYTSYLSREFVLYLLGMALVTTALSYFFRNFYPKDEMFEDLEGISERLAFFVFFLANKPFFAFLSLLLGFMYRLWKVKKFDHVWWISPAFAVVFSMIWKVIVF
>NC_011653.1|WP_148203262.1|358754_360827_-|fibronectin-type-III-domain-containing-protein
MFSHVFLGNSKESMQEIYSGIDNNLEKVLKPGTYYWKVQSKFGNKLIESSIATFTIVNNFPILEDVKASVDKNVVSFEWNAKDPDNDLLSYSLFLYDSSNNVNKIDLKNNFYRLNLPAGKYSWKIVCFDEFGGVTESKLNYFEINSEEEKVDFIPTFDIAKKKEGFLISFKRLEGYKYYLQILSDKEREIKLDKDFYLLTDIKEGVRYKVRLKVENESGQKIYSPYKEIFVESKDNVPPNFEVLFPKDGFSGISDKLVFRWNIKDDKAEPFVTLYLGTEKDKLKKIVSNYKAKSYEYKGLLPDTTYFWKLVVSDGVNSVESPIFEFKTGPLVEIIDIIGTENDDYVNDVLQINDDIYILMTSGENVILRDVSGKYNLDLNIKGEGVDVEEKDGVFYTLVNTKDGDYILSALKNGIFIFKKRYGGKYKDTAKKLMLSDDGIYILGDTWSDDFVHLYGWNDVFIQKLDYNGKVIWTRNYGGSEFDEAVSFAKTSKGYVIVGNTMSKDVDIPKNYGMKDIFVMYLDKNFTPKVTRVFGRENNDTVSALNVTDGFVYIVSKVYFNKDGETEDANIYYLKLNEDGVRLEEKLLGGSGNDICNDIKVYKDNVYLFGSTNSRDGDFYTYYTAKGFGDLFISNLGKWTIVNGGYEEDEIKYGLITKNGIIFIGNTSSHSGLFDKHIGNVDVFIGKIER
>NC_011653.1|WP_012579519.1|357020_358748_-|ABC-transporter-ATP-binding-protein
MIKDFVKKRFWFYLAGVFTLIVVDTLQLIVPKFISRAVDSLNVETPDVNVAKIMALGIVGIAIGMFITRFFWRFFIIGSARKFTYEARKILYDKILSLDMSFFDKHRSGDLMAHFTNDMNNIERMMGPGIVMMVDASFMSVITIFFMATSVGWKLTLIALIPLPLIVLISLVFGKFIYKRSKKVQDTFSDLSGFTEESIDGVRILKTFSILPKFEEIFQVKAKDNFKATLSLIKVWGIMWPLIHFISSMAYFITIAYGGPMVINQKITLGEFFAFNNYIGMIVWPLTAIGWVINIIQNGRASYNRVLNILNTQSKVVEPENQDIKIGSIDNIEIKDLNFAYPESDRLVLKNVNMRISKGQLVGIVGTVGSGKSTIVKIISKLYPVQRGHVFVNGYDINDIPSKIVRTKISYVPQETFLFSTSLKNNIAFGMEDFDEWQVKEYAMLSAVHSDIERFPKSYDTVVGERGVTLSGGQKQRVTIARALIRNSDVYIFDDCLSAVDPETEEKIIKTLRESMKNKTMVIITHRLKVLTNADMIYVFDNGEIIESGKHDELMNLNGLYAKMYRKQLIEEELS
>NC_011653.1|WP_012579518.1|355439_356993_-|bifunctional-UDP-sugar-hydrolase/5'-nucleotidase
MRNLKFLVILMVVLALSVFAVKISIFHVNDTHGHAWTFSEYHNPDIGGFAVIASIIDEERAKNPNVLFLHAGDINTGVPESDLLNALPDIFALNRMKLDAMAVGNHEFDKPRDVLKYQMSIAKFPFLSANIYKDGKPFFTPYIIKNVGGIKVAIFGLTTEETSILEPLYSQDLEFRNAIEVAKELVPMLREKADVVVALTHLGMGQEYEGNYTTSEELAQNVDGIDVIIDGHSHTKLEEAKVINNTIVVQAWEWGKIVGKLDLDVENGKIKEWNWTPIPVNLKVYKGKDENGNSIYEYVGKPYEPAMYVKVPLDYFAKLGSKKLDTVIGETKVLLDGERAHVRSGDTNLGHLITDAMLWKTGADIAFQNGGGIRASIEPGKITIRNILTVLPFGNTVYVMKMKGSDVMKVLEYAANIPEGKGAFLHVAGLTFESKNGKVTKVMVNGKPLEMDKVYKVVTNNYMAGGGDGYSMLKEAKATGYDTGFVLADVVVEYIQKGLGGKIDSYDDTPRYIRINE
>NC_011653.1|WP_004104037.1|355113_355377_+|stage-V-sporulation-protein-S
MEVLKVASGSNPNKVAGALAGVIREKGKAEVQAIGAGAVNQAVKAIAIARGYLAPSGIDLVCVPAFTDVNIENESRTALKFIVFPRE
>NC_011653.1|WP_004104061.1|372000_372207_-|heavy-metal-associated-domain-containing-protein
MGKFILKVPDMSCKHCVMRITKALEELGEKNFEVKLESKTVEIETENLENVKAKLSEIDYPVESVESL
>NC_011653.1|WP_004104063.1|372222_372465_-|SHOCT-domain-containing-protein
MCYLWNPFWRFYPGGGFIMMFFGLILLAVILYFLFKTFKPSFKGEFEDSALKILNEKLAKGEITEEEYKRKKELIMKGRF
>NC_011653.1|WP_012579528.1|372477_374664_-|copper-translocating-P-type-ATPase
MPEKKITFSVTGMTCANCARTVEKVLSKDENIKFASVNLATNTAFVVGDESIDLEKVKKLVESVGYGVSTEKPQQIEEKRFRQIKRSLIMALAVTIPISILMIINMFFVKVPYFVLLEVIGGAFVTFVAGKNTIKGAWIALTHKHTNMDTLIFFGALTSWLTSVLALFGFELASFGAIGTMIISFHLLGRFIESYLRDRATKEIKKLLSLQAREARVVINGEELFLPIEAVKENMLVIVKPGERIPVDGIVIEGASGVDESVVTGESMPVEKKENDEVVGGALNLTGILKIKVTKTGEDTFLSKMIQLIQEAQGAKVPIQALADRITNWFVPTIITLAVISGIFWYFGFDKFYPLLESARKIFPWILSTNDPLSFAIFAFVATVVIACPCALGLATPMALITGTSLAAKKGLLIRNAEAIQTMKDVKVVLMDKTGTITQGNPAVVDTNLDEEVKKIVASIEKNSNHPLAKAISKISEKYLEIKDIKEISGKGVIAKYDGKEYFVGKPEDYSRYETLLKEGYTVVEVRQDSEIVGYIAIEDPIRQDSKIAIENLKSLNVIPVMVTGDNEKTAKIVAEKVGIEKVHSQVKPDEKLEIVRKYQVEGNKVLMVGDGMNDAAALKGADVGIAIGSGTDLAIDNADIIITKEGISKIVDAIYISNLTFKVIKQNLFWAFFYNIIAIPMAMLGLLHPAIAEAAMAFSSITVILNSSKINERRYAKVFSSKKSCCI
>NC_011653.1|WP_004104067.1|374676_374949_-|metal-sensing-transcriptional-repressor
MKHKDALRTLKNARGQIDAIIKMIEENRYCIDISKQILAAISLLKKANVQVLNSHLETCVKSAAFSDDPQEVEQKIKELEDVISYLNKIV
>NC_011653.1|WP_012579529.1|375071_376925_-|ABC-transporter-ATP-binding-protein
MSEKIQRPARGHRGGPGGPIRAAVEKPKDFKKALKRLMIYLKPYMVPIIIVLAMAIAGTIFSIIAPKVLGKATTKLFQGYMAKRIFPKAKIDLNGILKILINVGILYGLFALFMYIQQYVMAGVSQKVVKKLRTDVMEKLSKLPLKFYDSRTHGEILSRVTNDVDLISNTLNQSLTQLITSIVTIVGVIVMMLTISPLLTLVTVVTLPISVGFIVFIVKKSQKYFKNQQVYLGNVNGHVEEMFSGLVVVKAYNKEEESIKKFEEYNQKLYDVAWKAQFVSGITMPVMRFVGNLGYVIVSVVGGIMVTKKAIQLGDVQAFIQYAQQFNQPISQVANIMNMIQSTLAAAERVFEILDEEEELPDPEDAIELEKVDGNVKFEHVYFSYREDKKLIEDLNIDVKSGQTVAIVGPTGAGKTTLVNLLMRFYEIQGGRITVDGIDIRKIKRDNLRRTFGMVLQDTWLFNGTIRENIAYGKEGATEEEIINAAKLAHAHHFIMALPGGYDAVINEDANNISQGEKQLITIARAFIADPEILILDEATSNVDTLTEKLIQKAMKRLMHSRTNFVIAHRLSTIRDADIILVMNEGQIIEKGTHDELMKKNGFYAELYKSQFLGAYV
>NC_011653.1|WP_012579530.1|376921_378646_-|ABC-transporter-ATP-binding-protein
MKGVVKYLKKYTFLIILAITFVVIQAILNLYLPDLMGDIVNKGVSRGNVDYILSVGWKMLFVTLLNVAAAIVSTYFAAKVAMGFGKDLRSHVYKKVMNFSLNEVDKYGVATLINRNTNDITQIQNVIFMMLRMVALAPVMAIGGTIMAISKSPKLTMVLLVSLPIMFVVMYFIVKYSMPLFKSMQKKLDNLNRVLRENLTGVRVIRAFAKTEYEKKRFEVANEDLTSTALKVNRIFALVFPLILLIMNFTIIFLIWIGAIQIDKGTLEVGTMMAVMQYIMQIMFSFIMISVVFIFLPRASASAERVAQVLNEKERIKDVKSPKKLEGMGKVEFKNVTFYYEGGKEPAIENANFEINPGEVVGIIGSSGSGKSTLVKLLMRFYDVTSGEILIDGVNIKELSQKDLRDMISFTPSRPVIFSGTIEENVRIGKEDATEEEIVEALKTAQAWEFVSKLPEGIKTQVSQGGTNLSGGQKQRLAIARGIVGKRKIYIFDDSFSALDFKTDAKLRKELREKLKDATKIIVSLRVATVMNADKIIVLDKGRVVGIGTHKKLMKSCEVYREIVSSQLSEEEIA
>NC_011653.1|WP_012579531.1|378629_379082_-|MarR-family-transcriptional-regulator
MVDNFEFSSTFLLFSEIERLKFQILKSEMDKYKIHPGQIPIFFIVRKNPGISQKDLAKKVMLSTSTVAIMLRRMEKAGFVKRIQDESDRRFYHIYLTDKALKIVDKIFKRLKEFERQSFENFTNEEMEVLEKLLKKILLNLEAMKDERCC
>NC_011653.1|WP_012579532.1|379190_380405_-|iron-containing-alcohol-dehydrogenase
MWESKMDIYNVFELRCKTTCYFGVGAIKKISDILDNLKAQGINNVIFVTDKIAYKVTGAWDVIEPELKAKGFKYVIYEDVSPNPTTAQINEATKLGLQNGAQAVIGIGGGSPIDTAKSVAILLEYPEKTAEELYEGLFTPEKAKPIIAINTTHGTGTEVDRFAVASILEKEYKPAIAYDCIYPLYAIDDPQLMVTLPKGQTVFTSIDAVNHVTEAATTLVASPYSILLAKETIRLIARYLPQAVAHPDDLTARYYLLYASAIAGISFDNGMLHFTHALEHPLSAVKPDLAHGLGLAMLLPAVVKHIYIAKPEVLADIYEPIVPGLKGVPGEAEKIAAGIEKWLFNLGVTEKLEDMGFTENDVEKLTKLALETPSLGLLLSMAPIKADEKTIASIYRDSLKPISR
>NC_011653.1|WP_004104076.1|382438_382780_+|hypothetical-protein
MATFGYDLYFITDKNSIITYNPLTKMGEIILKEFDHGRIKNLAIEPYTKSIFISFTNNDQDMSIGYVDLKEQVVKVIDNEKVSDFLGILFNKGFLCVIKKDGYKVFSILDIVK
>NC_011653.1|WP_081429687.1|383130_383469_+|hypothetical-protein
MLNIENCYDDNEYNQELITWINVVGIHKEEIIEKIGKYFNLHSLTLEDILNIYQRSELEEFEDYIFIVLKDLKFEENGNLIDVNQISIVIKGNYIITFSEKIQTSLIILLNI

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Crispr_ID: NC_011653_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011653_5

499002-501657

Orphan

Consensus_repeat	Method
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CRISPRCasFinder
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CRT
AGTTTAGAATCTACCTATGAGGAATGAAAACAT	PILER-CR
GTTTAGAATCTACCTATGAGGAATGAAAAC	PILER-CR

37 spacers

The CRISPR arrays of NC_011653_5

>merge|NC_011653|5|499002-501657|CRISPRCasFinder,CRT,PILER-CR,PILER-CR
GAACACATTGCTAATAGGTAAATTCTAAACAAAAACGACATATTTTGAAAAAGTACTGTTCAAAGAAATGTTTTCATTCATCATAGGTAGATTCTAAACTCCGAACTGGCCCACCAACCGGCGCCTTCCGCACATTATGTTTTCATTCCTCATAAGTAGATTCTAAACTTTTGCAGACGCCTGCAAAATCGTTTTTGGTAGGAGATTCAAGTTTTCATTCCTCATAGGTAGATTCTAAACTCCGAACTGGCCCACCAACCGACGCCTTCCGCACATTATGTTTTCATTCCTCATAGGTAGATTCTAAACGCGGGTTTTTTATTTGTACCTGCGTCTGGAGCACCTTTTTTGTGTTTTCATTCCTCATAGGTAGATTCTAAACCTTTATTAAATGCATTACCTTACATAAAAGTTAAAAAGGTTTTCATTCCTCATAGGTAGATTCTAAACTCCATTCTTACAATTGTGTTAAATATCACTGAGGAACCCGCATACGTTTTCATTCCTCATAGGTAGATTCTAAACTATAGTTACAAAAGACGAAATATTTGTTGTTCCATGCAACTATTGTTTTCATTCCTCATAGGTAGATTCTAAACGAATACAAACCATCAATCTGGACAGACGCATACATTCGTTTTCATTCCTCATAGGTAGATTCTAAACTCTTTTAAACGATTATACAGTTCCTTGCCGATAGGATGTGTTTTCATTCCTCATAGGTAGATTCTAAACGGTTATATACAAAATAAAGGGCCCTGGAGCCCTTTATAGTAAGTTTTCATTCCTCATAGGTAGATTCTAAACTGTCTGAGTAGGGAAGGGAGATGACCAAAAGAACCTTGGGTTTTCATTCCTCATAGGTAGATTCTAAACCTGGACTGATGGCTGGAGAAACGAATTTTACGAGGCTGCAAAGTTTTCATTCCTCATAGGTAGATTCTAAACGGACCTTTTTTACATAATTATATCACATTTTGATTTAAATAAGTTTTCATTCCTCATAGGTAGATTCTAAACTGGCAACTATTAAGCGAGTTTGGAGAAATAGGAAATGAGTTTTCATTCCTCATAGGTAGATTCTAAACGCCTGTAATTTGTCCTATAACATGTCTTGTGCGAATTGGTGTGTTTTCATTCCTCATAGGTAGATTCTAAACATATTGAATTCAAAATAGCGCTTTTTTCGGCTTCTGACACTGTTGTTTTCATTCCTCATAGGTAGATTCTAAACAAAAGTGAATAGGTAGGTGGCGAAAGTAGGGCGCCTGAGGAGGAGTTTTCATTCCTCATAGGTAGATTCTAAACATTTAAGAGATGCAGTTAAAGATTTTAATTTGAACAAGTGGATGTTTTCATTCCTCATAGGTAGATTCTAAACCAGTATATGAAGCTATTGCAAGAAAAAGAGATAAGCAAACAATGTTTTCATTCCTCATAGGTAGATTCTAAACGGATATTATGATGTTAGTAAAAAGATTTGATTTAGTCAAGTTTTCATTCCTCATAGGTAGATTCTAAACCCGAGTTATTCCAAAATTATTATTTTGGGGCACATTGGAAACATTAGTTTTCATTCCTCATAGGTAGATTCTAAACGTTTTTCAGAGTAGGTATAATGGCTCCTTAAATAGGTTTTAGTTTTCATTCCTCATAGGTAGATTCTAAACCAAAATGGCGAACATCATTAGTTGTAAGAGAATGGAGTTGTTTTCATTCCTCATAGGTAGATTCTAAACAATAGACATCGTTACGATGGAAAATTTACCACAAGCTATTGGTTGTTTTCATTCCTCATAGGTAGATTCTAAACTCCTTTTTTAGATGCAACAGCTTTTATGAGATATTATTATTTAGTTTTCATTCCTCATAGGTAGATTCTAAACCATGGTTATAAATTTAAGTATTTTTGGGTTAAGGAGTTGGTTTTCATTCCTCATAGGTAGATTCTAAACTTATATGCAAAACGTGGCAGAAACACAATTGTGTTTACTCGTTTTCATTCCTCATAGGTAGATTCTAAACAAGAATTACTATATAGGCAAAAGAATAAGTATTAATTCGTTTTCATTCCTCATAGGTAGATTCTAAACTGAATTTATTGAATACACGGGTATAATTCAAGATGTAATTTTCGTTTTCATTCCTCATAGGTAGATTCTAAACAACGTTCGAAGTAACAGGATTAGACAAAATTACCAAGGGTTTTCATTCCTCATAGGTAGATTCTAAACCAATTATGGTGTCAGTTACTACATTGTATAACACGAAAATGAAGTTTTCATTCCTCATAGGTAGATTCTAAACTATGAAACTAACCAAGAGGACGGGAGCGGGCGAGAAACAAAGTTTTCATTCCTCATAGGTAGATTCTAAACTGAGAAATATATCGAACAATTTGTAAAAGATTACAACTCAGACCGTTTTCATTCCTCATAGGTAGATTCTAAACTTTTTAAAAGAAGCAGAGGACTATCTAGAAATAACAGTTTTCATTCCTCATAGGTAGATTCTAAACTTACTAGAGCAGTTTGAGGGGTTCATTCAAGAAGTTCTGTTTTCATTCCTCATAGGTAGATTCTAAACACCTGTTTGCCAAAATAAGAAACAGAAAAACAATTGAATTGTTTTCATTCCTCATAGGTAGATTCTAAAC

>NC_011653|5|5|499002-501657|CRISPRCasFinder
GAACACATTGCTAATAGGTAAATTCTAAAC	AAAAACGACATATTTTGAAAAAGTACTGTTCAAAGAAAT
GTTTTCATTCATCATAGGTAGATTCTAAAC	TCCGAACTGGCCCACCAACCGGCGCCTTCCGCACATTAT
GTTTTCATTCCTCATAAGTAGATTCTAAAC	TTTTGCAGACGCCTGCAAAATCGTTTTTGGTAGGAGATTCAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCCGAACTGGCCCACCAACCGACGCCTTCCGCACATTAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCGGGTTTTTTATTTGTACCTGCGTCTGGAGCACCTTTTTTGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTTTATTAAATGCATTACCTTACATAAAAGTTAAAAAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCCATTCTTACAATTGTGTTAAATATCACTGAGGAACCCGCATAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TATAGTTACAAAAGACGAAATATTTGTTGTTCCATGCAACTATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAATACAAACCATCAATCTGGACAGACGCATACATTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCTTTTAAACGATTATACAGTTCCTTGCCGATAGGATGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGTTATATACAAAATAAAGGGCCCTGGAGCCCTTTATAGTAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTCTGAGTAGGGAAGGGAGATGACCAAAAGAACCTTGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTGGACTGATGGCTGGAGAAACGAATTTTACGAGGCTGCAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGACCTTTTTTACATAATTATATCACATTTTGATTTAAATAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGGCAACTATTAAGCGAGTTTGGAGAAATAGGAAATGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCCTGTAATTTGTCCTATAACATGTCTTGTGCGAATTGGTGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATATTGAATTCAAAATAGCGCTTTTTTCGGCTTCTGACACTGTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAAAGTGAATAGGTAGGTGGCGAAAGTAGGGCGCCTGAGGAGGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTAAGAGATGCAGTTAAAGATTTTAATTTGAACAAGTGGAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAGTATATGAAGCTATTGCAAGAAAAAGAGATAAGCAAACAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGATATTATGATGTTAGTAAAAAGATTTGATTTAGTCAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CCGAGTTATTCCAAAATTATTATTTTGGGGCACATTGGAAACATTA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GTTTTTCAGAGTAGGTATAATGGCTCCTTAAATAGGTTTTA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAAAATGGCGAACATCATTAGTTGTAAGAGAATGGAGTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AATAGACATCGTTACGATGGAAAATTTACCACAAGCTATTGGTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCCTTTTTTAGATGCAACAGCTTTTATGAGATATTATTATTTA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CATGGTTATAAATTTAAGTATTTTTGGGTTAAGGAGTTG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTATATGCAAAACGTGGCAGAAACACAATTGTGTTTACTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAGAATTACTATATAGGCAAAAGAATAAGTATTAATTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAATTTATTGAATACACGGGTATAATTCAAGATGTAATTTTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AACGTTCGAAGTAACAGGATTAGACAAAATTACCAAGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAATTATGGTGTCAGTTACTACATTGTATAACACGAAAATGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TATGAAACTAACCAAGAGGACGGGAGCGGGCGAGAAACAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAGAAATATATCGAACAATTTGTAAAAGATTACAACTCAGACC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTTTTAAAAGAAGCAGAGGACTATCTAGAAATAACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTACTAGAGCAGTTTGAGGGGTTCATTCAAGAAGTTCT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACCTGTTTGCCAAAATAAGAAACAGAAAAACAATTGAATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC

>NC_011653|5|5|499002-501657|CRT
GAACACATTGCTAATAGGTAAATTCTAAAC	AAAAACGACATATTTTGAAAAAGTACTGTTCAAAGAAAT
GTTTTCATTCATCATAGGTAGATTCTAAAC	TCCGAACTGGCCCACCAACCGGCGCCTTCCGCACATTAT
GTTTTCATTCCTCATAAGTAGATTCTAAAC	TTTTGCAGACGCCTGCAAAATCGTTTTTGGTAGGAGATTCAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCCGAACTGGCCCACCAACCGACGCCTTCCGCACATTAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCGGGTTTTTTATTTGTACCTGCGTCTGGAGCACCTTTTTTGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTTTATTAAATGCATTACCTTACATAAAAGTTAAAAAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCCATTCTTACAATTGTGTTAAATATCACTGAGGAACCCGCATAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TATAGTTACAAAAGACGAAATATTTGTTGTTCCATGCAACTATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAATACAAACCATCAATCTGGACAGACGCATACATTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCTTTTAAACGATTATACAGTTCCTTGCCGATAGGATGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGTTATATACAAAATAAAGGGCCCTGGAGCCCTTTATAGTAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTCTGAGTAGGGAAGGGAGATGACCAAAAGAACCTTGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTGGACTGATGGCTGGAGAAACGAATTTTACGAGGCTGCAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGACCTTTTTTACATAATTATATCACATTTTGATTTAAATAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGGCAACTATTAAGCGAGTTTGGAGAAATAGGAAATGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCCTGTAATTTGTCCTATAACATGTCTTGTGCGAATTGGTGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATATTGAATTCAAAATAGCGCTTTTTTCGGCTTCTGACACTGTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAAAGTGAATAGGTAGGTGGCGAAAGTAGGGCGCCTGAGGAGGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTAAGAGATGCAGTTAAAGATTTTAATTTGAACAAGTGGAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAGTATATGAAGCTATTGCAAGAAAAAGAGATAAGCAAACAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGATATTATGATGTTAGTAAAAAGATTTGATTTAGTCAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CCGAGTTATTCCAAAATTATTATTTTGGGGCACATTGGAAACATTA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GTTTTTCAGAGTAGGTATAATGGCTCCTTAAATAGGTTTTA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAAAATGGCGAACATCATTAGTTGTAAGAGAATGGAGTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AATAGACATCGTTACGATGGAAAATTTACCACAAGCTATTGGTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCCTTTTTTAGATGCAACAGCTTTTATGAGATATTATTATTTA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CATGGTTATAAATTTAAGTATTTTTGGGTTAAGGAGTTG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTATATGCAAAACGTGGCAGAAACACAATTGTGTTTACTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAGAATTACTATATAGGCAAAAGAATAAGTATTAATTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAATTTATTGAATACACGGGTATAATTCAAGATGTAATTTTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AACGTTCGAAGTAACAGGATTAGACAAAATTACCAAGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAATTATGGTGTCAGTTACTACATTGTATAACACGAAAATGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TATGAAACTAACCAAGAGGACGGGAGCGGGCGAGAAACAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAGAAATATATCGAACAATTTGTAAAAGATTACAACTCAGACC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTTTTAAAAGAAGCAGAGGACTATCTAGAAATAACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTACTAGAGCAGTTTGAGGGGTTCATTCAAGAAGTTCT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACCTGTTTGCCAAAATAAGAAACAGAAAAACAATTGAATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC

>NC_011653|5|8|499007-499170|PILER-CR
CATTGCTAATAGGTAAATTCTAAACAAAAACGA	CATATTTTGAAAAAGTACTGTTCAAAGAAATGTTTT
CATTCATCATAGGTAGATTCTAAACTCCGAACT	GGCCCACCAACCGGCGCCTTCCGCACATTATGTTTT
CATTCCTCATAAGTAGATTCTAAACTTTTGCAGACGCCTGCAAAATCGTTTTTGGTAGGAGATTCAAGTTTTCATTCCTCATAGGTAGATTCTAAACTCCGAACTGGCCCACCAACCGACGCCTTCCGCACATTATGTTTTCATTCCTCATAGGTAGATTCTAAACGCGGGTTTTTTATTTGTACCTGCGTCTGGAGCACCTTTTTTGTGTTTTCATTCCTCATAGGTAGATTCTAAAC	CTTTATTAAATGCATTACCTTACATAAAAGTTAAAAAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCCATTCTTACAATTGTGTTAAATATCACTGAGGAACCCGCATAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TATAGTTACAAAAGACGAAATATTTGTTGTTCCATGCAACTATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAATACAAACCATCAATCTGGACAGACGCATACATTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCTTTTAAACGATTATACAGTTCCTTGCCGATAGGATGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGTTATATACAAAATAAAGGGCCCTGGAGCCCTTTATAGTAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTCTGAGTAGGGAAGGGAGATGACCAAAAGAACCTTGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTGGACTGATGGCTGGAGAAACGAATTTTACGAGGCTGCAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGACCTTTTTTACATAATTATATCACATTTTGATTTAAATAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGGCAACTATTAAGCGAGTTTGGAGAAATAGGAAATGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCCTGTAATTTGTCCTATAACATGTCTTGTGCGAATTGGTGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATATTGAATTCAAAATAGCGCTTTTTTCGGCTTCTGACACTGTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAAAGTGAATAGGTAGGTGGCGAAAGTAGGGCGCCTGAGGAGGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTAAGAGATGCAGTTAAAGATTTTAATTTGAACAAGTGGAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAGTATATGAAGCTATTGCAAGAAAAAGAGATAAGCAAACAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGATATTATGATGTTAGTAAAAAGATTTGATTTAGTCAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CCGAGTTATTCCAAAATTATTATTTTGGGGCACATTGGAAACATTA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GTTTTTCAGAGTAGGTATAATGGCTCCTTAAATAGGTTTTA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAAAATGGCGAACATCATTAGTTGTAAGAGAATGGAGTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AATAGACATCGTTACGATGGAAAATTTACCACAAGCTATTGGTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCCTTTTTTAGATGCAACAGCTTTTATGAGATATTATTATTTA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CATGGTTATAAATTTAAGTATTTTTGGGTTAAGGAGTTG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTATATGCAAAACGTGGCAGAAACACAATTGTGTTTACTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAGAATTACTATATAGGCAAAAGAATAAGTATTAATTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAATTTATTGAATACACGGGTATAATTCAAGATGTAATTTTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AACGTTCGAAGTAACAGGATTAGACAAAATTACCAAGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAATTATGGTGTCAGTTACTACATTGTATAACACGAAAATGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TATGAAACTAACCAAGAGGACGGGAGCGGGCGAGAAACAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAGAAATATATCGAACAATTTGTAAAAGATTACAACTCAGACC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTTTTAAAAGAAGCAGAGGACTATCTAGAAATAACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTACTAGAGCAGTTTGAGGGGTTCATTCAAGAAGTTCT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACCTGTTTGCCAAAATAAGAAACAGAAAAACAATTGAATT


>NC_011653|5|9|499354-501657|PILER-CR
	CATATTTTGAAAAAGTACTGTTCAAAGAAATGTTTT
CATTCATCATAGGTAGATTCTAAACTCCGAACT	GGCCCACCAACCGGCGCCTTCCGCACATTATGTTTT
CATTCCTCATAAGTAGATTCTAAACTTTTGCAGACGCCTGCAAAATCGTTTTTGGTAGGAGATTCAAGTTTTCATTCCTCATAGGTAGATTCTAAACTCCGAACTGGCCCACCAACCGACGCCTTCCGCACATTATGTTTTCATTCCTCATAGGTAGATTCTAAACGCGGGTTTTTTATTTGTACCTGCGTCTGGAGCACCTTTTTTGTGTTTTCATTCCTCATAGGTAGATTCTAAAC	CTTTATTAAATGCATTACCTTACATAAAAGTTAAAAAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCCATTCTTACAATTGTGTTAAATATCACTGAGGAACCCGCATAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TATAGTTACAAAAGACGAAATATTTGTTGTTCCATGCAACTATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAATACAAACCATCAATCTGGACAGACGCATACATTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCTTTTAAACGATTATACAGTTCCTTGCCGATAGGATGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGTTATATACAAAATAAAGGGCCCTGGAGCCCTTTATAGTAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTCTGAGTAGGGAAGGGAGATGACCAAAAGAACCTTGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTGGACTGATGGCTGGAGAAACGAATTTTACGAGGCTGCAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGACCTTTTTTACATAATTATATCACATTTTGATTTAAATAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGGCAACTATTAAGCGAGTTTGGAGAAATAGGAAATGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCCTGTAATTTGTCCTATAACATGTCTTGTGCGAATTGGTGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATATTGAATTCAAAATAGCGCTTTTTTCGGCTTCTGACACTGTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAAAGTGAATAGGTAGGTGGCGAAAGTAGGGCGCCTGAGGAGGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTAAGAGATGCAGTTAAAGATTTTAATTTGAACAAGTGGAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAGTATATGAAGCTATTGCAAGAAAAAGAGATAAGCAAACAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGATATTATGATGTTAGTAAAAAGATTTGATTTAGTCAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CCGAGTTATTCCAAAATTATTATTTTGGGGCACATTGGAAACATTA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GTTTTTCAGAGTAGGTATAATGGCTCCTTAAATAGGTTTTA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAAAATGGCGAACATCATTAGTTGTAAGAGAATGGAGTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AATAGACATCGTTACGATGGAAAATTTACCACAAGCTATTGGTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCCTTTTTTAGATGCAACAGCTTTTATGAGATATTATTATTTA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CATGGTTATAAATTTAAGTATTTTTGGGTTAAGGAGTTG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTATATGCAAAACGTGGCAGAAACACAATTGTGTTTACTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAGAATTACTATATAGGCAAAAGAATAAGTATTAATTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAATTTATTGAATACACGGGTATAATTCAAGATGTAATTTTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AACGTTCGAAGTAACAGGATTAGACAAAATTACCAAGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAATTATGGTGTCAGTTACTACATTGTATAACACGAAAATGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TATGAAACTAACCAAGAGGACGGGAGCGGGCGAGAAACAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAGAAATATATCGAACAATTTGTAAAAGATTACAACTCAGACC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTTTTAAAAGAAGCAGAGGACTATCTAGAAATAACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTACTAGAGCAGTTTGAGGGGTTCATTCAAGAAGTTCT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACCTGTTTGCCAAAATAAGAAACAGAAAAACAATTGAATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011653.1\|WP_012579625.1\|516679_517246_+\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|273579
NC_011653.1\|WP_012579623.1\|514618_515266_+\|dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|99789
NC_011653.1\|WP_012579613.1\|482460_483741_-\|serine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235461
NC_011653.1\|WP_012579619.1\|508264_509647_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NC_011653.1\|WP_004104343.1\|495382_496348_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|184118
NC_011653.1\|WP_004104295.1\|487368_489846_-\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NC_011653.1\|WP_004104297.1\|489943_490624_+\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl\|CDD\|236959
NC_011653.1\|WP_012579621.1\|511248_512283_+\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|377382
NC_011653.1\|WP_081429720.1\|504148_505594_-\|site-2-protease-family-protein	unknown	unknown	gnl\|CDD\|308008
NC_011653.1\|WP_012579614.1\|483746_484787_-\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|235578
NC_011653.1\|WP_004100667.1\|516077_516689_+\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|273785
NC_011653.1\|WP_004100674.1\|512260_513292_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012579615.1\|494919_495396_+\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012580542.1\|509636_510767_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_011653.1\|WP_004104293.1\|486354_487356_-\|peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|234605
NC_011653.1\|WP_012579622.1\|513504_514641_+\|dihydroorotase	unknown	unknown	gnl\|CDD\|236479
NC_011653.1\|WP_012579624.1\|515262_516081_+\|tRNA-dihydrouridine-synthase	unknown	unknown	gnl\|CDD\|240091
NC_011653.1\|WP_004104291.1\|484976_486287_+\|alkaline-phosphatase	unknown	unknown	gnl\|CDD\|224699
NC_011653.1\|WP_004104299.1\|490636_490990_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341465
NC_011653.1\|WP_012579616.1\|496319_496964_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_011653.1\|WP_012579625.1\|516679_517246_+\|orotate-phosphoribosyltransferase	gnl\|CDD\|273579	TIGR01367, Orotate_phosphoribosyltransferase, orotate phosphoribosyltransferase, Thermus family. This model represents a distinct clade of orotate phosphoribosyltransferases. Members include the experimentally determined example from Thermus aquaticus and additional examples from Caulobacter crescentus, Helicobacter pylori, Mesorhizobium loti, and related species. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis].	1.1638e-82
NC_011653.1\|WP_012579623.1\|514618_515266_+\|dihydroorotate-dehydrogenase	gnl\|CDD\|99789	cd06192, DHOD_e_trans_like, FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as NAD binding. NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal domain may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Ferredoxin is reduced in the final stage of photosystem I. The flavoprotein Ferredoxin-NADP+ reductase transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) which then transfers a hydride ion to convert NADP+ to NADPH.	1.95482e-42
NC_011653.1\|WP_012579613.1\|482460_483741_-\|serine--tRNA-ligase	gnl\|CDD\|235461	PRK05431, PRK05431, seryl-tRNA synthetase; Provisional.	0
NC_011653.1\|WP_012579619.1\|508264_509647_-\|HD-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	2.03521e-34
NC_011653.1\|WP_004104343.1\|495382_496348_+\|AAA-family-ATPase	gnl\|CDD\|184118	PRK13531, PRK13531, regulatory ATPase RavA; Provisional.	9.54793e-29
NC_011653.1\|WP_012580542.1\|509636_510767_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	4.60903e-47
NC_011653.1\|WP_004104297.1\|489943_490624_+\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl\|CDD\|236959	PRK11713, PRK11713, 16S ribosomal RNA methyltransferase RsmE; Provisional.	6.54611e-60
NC_011653.1\|WP_012579621.1\|511248_512283_+\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	gnl\|CDD\|377382	pfam04551, GcpE, GcpE protein. In a variety of organisms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.	0
NC_011653.1\|WP_081429720.1\|504148_505594_-\|site-2-protease-family-protein	gnl\|CDD\|308008	pfam02163, Peptidase_M50, Peptidase family M50.	2.41982e-39
NC_011653.1\|WP_012579614.1\|483746_484787_-\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|235578	PRK05720, mtnA, methylthioribose-1-phosphate isomerase; Reviewed.	0
NC_011653.1\|WP_004100667.1\|516077_516689_+\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|273785	TIGR01740, Orotidine_5'-phosphate_decarboxylase, orotidine 5'-phosphate decarboxylase, subfamily 1. This model represents orotidine 5'-monophosphate decarboxylase, the PyrF protein of pyrimidine nucleotide biosynthesis. In many eukaryotes, the region hit by this model is part of a multifunctional protein. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis].	1.56303e-43
NC_011653.1\|WP_012579624.1\|515262_516081_+\|tRNA-dihydrouridine-synthase	gnl\|CDD\|240091	cd04740, DHOD_1B_like, Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires FMN as co-factor. DHOD divides into class 1 and class 2 based on their amino acid sequences and cellular location. Members of class 1 are cytosolic enzymes and multimers while class 2 enzymes are membrane associated and monomeric. The class 1 enzymes can be further divided into subtypes 1A and 1B which are homodimers and heterotetrameric proteins, respectively.	5.03646e-72
NC_011653.1\|WP_004104293.1\|486354_487356_-\|peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|234605	PRK00059, prsA, peptidylprolyl isomerase; Provisional.	1.29471e-29
NC_011653.1\|WP_012579622.1\|513504_514641_+\|dihydroorotase	gnl\|CDD\|236479	PRK09357, pyrC, dihydroorotase; Validated.	8.36513e-145
NC_011653.1\|WP_004104291.1\|484976_486287_+\|alkaline-phosphatase	gnl\|CDD\|224699	COG1785, PhoA, Alkaline phosphatase [Inorganic ion transport and metabolism].	2.37523e-141
NC_011653.1\|WP_004104299.1\|490636_490990_+\|hypothetical-protein	gnl\|CDD\|341465	cd08186, Fe-ADH-like, Iron-containing alcohol dehydrogenase. This family contains iron-containing alcohol dehydrogenase (ADH) which catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. The ADH of hyperthermophilic archaeon Thermococcus hydrothermalis oxidizes a series of primary aliphatic and aromatic alcohols, preferentially from C2 to C8, but is also active towards methanol and glycerol, and is stereospecific for monoterpenes. It has been suggested that the type III ADHs in microorganisms are involved in acetaldehyde detoxication rather than in alcohol turnover.	0.00656636
NC_011653.1\|WP_004104295.1\|487368_489846_-\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0

>NC_011653.1|WP_012579616.1|496319_496964_+|hypothetical-protein
MKLKDISYTDIKHLKWIFSTVTVEDAKNGAIVLGVELYNLFVYKKHYTDFFEIKLFFDNLKGILPRSINSEEACVYISKVLNYFFDYDGELLYTNSNRSLVKILEKYYDEKYSKNLGKLLNDNIDYFIVLFNKSNNGLIENVLMQSNIILDNKVYIDKCANFKKDISEVYVSTDEKMNQNVEEIKRIRDLEDLKNLLPSYYLFFEEEYESILLP
>NC_011653.1|WP_004104343.1|495382_496348_+|AAA-family-ATPase
MKKDRTSGNFRELTRMFKNYLEVIYTLKNIILNKDDVIDAISCGFLTQTNVLLIGEPGTAKSLVINEFAKLMGFDIENGYFHYLLTKFTEPSEVLGPLNISELKKGKYVINTKNKLPEANVVFLDEVFNANSAILNSLLTLINEKKLLLGDIYKSLDDLIVIYGATNHTPTDPLLKAFYDRFPIRVLVEGVERKDYEELLDREFDIEEKNLRKDKEILFDRKESIMFSKMMNEYIMMKYFELRQNKYITDLLDRIEMLKKDKDIFISDRNLKFYVKNMIAYSMIRNESLNPNLNLEDLKFILSKIFNNEEQKYEIERYFIY
>NC_011653.1|WP_012579615.1|494919_495396_+|hypothetical-protein
MNHDDILNLTFEENEKDLFVESLRYFFEKSLIINPTYFIYYLLIKKNKSKEYILRFFIEIVIKNNIPIKEANLEFLYMIYEYNSIQKINSLIDEYKNEKSETIDYKKYLDRIEKVYDTTLNPISNKIELLYRLHLLPKTKNEYFKEIIMEGVNQYEKG
>NC_011653.1|WP_004104299.1|490636_490990_+|hypothetical-protein
MEKGKKIISFVKYEHEIEPSYREKLANAKRKSDVREVFINTLLELLSSIDPEFNEFSQEDIKFESEYYEFSKKLEEKLEKFKDSDLHAIIERIFEAAKNRYLKIEHDENTDYFNLKK
>NC_011653.1|WP_004104297.1|489943_490624_+|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MPNLFFGIKEDNNLIFDEHETVHIKTVRKKENDIIECTDGKGYYYKVKITQIGKKKSFGEILESKYIENNEKTFLSLFAPASRWERLRWLIEKSVELGVDNIYITKTAFSNRDYKDKVEKINMVIRDSAKQCVRFHFPNVDFITFKNIKNYATKNTYFLDFNGQKLPANIDGDVSIIVGPEGGFSKEELDFLFSNFNAIRLGNKILRFETAAFVALSYFAIVLNKI
>NC_011653.1|WP_004104295.1|487368_489846_-|leucine--tRNA-ligase
MKEYIPGQIEKKWQKVWEEEKVFETPQYSEKPKFYDLVMFPYPSGTLHVGHVKNYVIGDIVARYKRMKGFNVLHPFGYDAFGLPAENAAIKNKIHPEVWTFKNIETIRNQIKKIGISYDWKREIATCTEDYYKWTQWLFVKMYEKGLAYKKKAAVNWCPSCQTVLANEQVVDGKCERCGTEVTLKHLEQWYFKITDYAERLLNDLERLEGWPENVKTMQKNWIGKSTGAEIDFKVDGLDMSIRVFTTRPDTIWGVTFMAIAPESPLVETLVTEDKKEELEEFLKKVSLEDRFKRTSLEAEKEGFFLGRYAINPVTGEKIPIYVANYILYEYGTGAIMAVPAHDQRDFDFAKKYNIPIRLVIDNPESPIDVEKMEKAYEDEGIMVNSGPFNGISSKEAIEKIIDYLEEKNIGKRSVQYKLRDWLISRQRYWGAPIPVVYCEKCGTVAVPEEQLPVKLPKDVEFLPTGQSPLSLDEQFLNTTCPKCGGPARREADTMDTFVDSSWYYLRYVNPNLEDKPFESKDVNYWLPVDQYIGGVEHAVLHLLYSRFITKVLHDMGYVDFDEPFTNLFTQGMIYKDGWKMSKSKGNVVSPDDMIEKYGADTLRTYILFMAPPEKDAEWSDAGIEGVHRFLKRLWNNIYSVLEKIKNVSAEKIELKNKLEKDLRRKLHQSIKKITEDIEGGFKFNTAIAGLMELNNSFSDYLNKTEEKDLNLPLLRELVEKLALILSPFAPHMAEEIWHDLGNDTLIVNEEWPKYDEKALEVDEVTVIIQINGKVRGKINVDVNADEETVKKIAFEEPKVSSYIEGKEIVKVIYVKNKLLNIVVK
>NC_011653.1|WP_004104293.1|486354_487356_-|peptidyl-prolyl-cis-trans-isomerase
MKRFLLLLLVVFSVVIFSEELPATSTVAVVNGEAITLEQLNRAADVQKLMIGISQVDQTFFSVLSNTEEGVKVILRYKRVVLDDLVNKLLIVQFAQKYGARLSEEEVRNVVDKQISDYLDQQGIDEKTFDMYLQYANMGTLEDFKEKMYFETLVNLSLERLFNVVTKDATVSDEELMDYYQKHIDEYSTPTQYTLSLIAFDNEKVANAVKTKIVSGETFDSIASEYGISQFKYENIAEDTTFPGKLWNYIKNAPQGALLGPIDVDEKYYIFKVENVVPMQSKKFDEVREEISNMILSEKKKNMWANFIDSEFSKFKNESTVEVYYKVDVEQKN
>NC_011653.1|WP_004104291.1|484976_486287_+|alkaline-phosphatase
MKKLLLILLLLVSVFSFSVKNVIYMIGDGMGINHVMLASYLEGRLLEFMKTQNIALVTTHSANSNVTDSAAAGTALFTGFKTNNGMIGILPDGTTVPTIAEIAAKHGVKIGIIATSRITHATPGAVYGHVNSRSNENTLAEQLVNSPITVAFGGGWRHFVATGGKRNDGKDLIKLAKEKGFDYITTKEQLLNYNGKKVIGLFNSSHLPAYTDRVNEPTLSEMTKKALEILSKDNSPFFLMIEGSQIDWEAHGNDPYGVWKEIIEFEEAFKVAMEFLKQNPDTLIIVTADHETGGLGLSSGGYYFDVEMIRKFSKNTDFISKESNKDKNKLKELIKKYYQLELTDEDLELFDSLVKEQGNSYYAFSNAIGRLVSKKAHLGWTTYDHTGAPVALYAFGQGADNFKGLIDNTEIPRIIARLAGYPLTFPTYKLPVSGGH
>NC_011653.1|WP_012579614.1|483746_484787_-|S-methyl-5-thioribose-1-phosphate-isomerase
MKLKTMTMEWTGDELILIDQRKIPLVEEYVSCKSYKEVAVAIKDMVVRGAPAIGASAAFGYVLGAREMFVEDFNAFVKKMEEVKEVLANTRPTAVNLFWALNRMEDSLKKYGKIEGILEYLEEEAMNIAKEDIEVNKAIGRYGAELLKDGDTVLTHCNAGALATVDYGTALGVIRAAVEQGKKIKVFADETRPYLQGARLTAWELMKDGIDVTLISDNMSGWSMKLGKINAVIVGADRVAANGDVANKIGTYMVAVLAKRHGIPFYVAAPTSTIDLNTKTGKDIPIEERKHTEVTHCGGKQIAPDGVKVFNPAFDVTDAELVTAIITEKGVVYPPYEENLKKLFEE
>NC_011653.1|WP_012579613.1|482460_483741_-|serine--tRNA-ligase
MIDVKLLRKNPEIFYDAIKKRNMDTEIIDKILEVDKEWRELVAKVNELKAKRNEFSKLVAKAKVEKDNEKASKLIEESKKIGEEIKKIEEQEKKLEEEMQNLALNIPNIPAEDVPFGKDESENIEIRRWGEPRKFDFEPKAHWDLGPELSMMDFERGAKLSGSRFTVLYSYLARLERALIQFMLDVHTKEHGYTEVWVPQLVKRDAMLWTGKLPKFEEDAYCIEKDDMFLIPTAEVPLVALHAQEILSEKDLPIKYTAYSACYRREAGSYGKDVRGMIRQHQFDKVELVWITTPERSFEDLERLTQDAERILQLLELPYRVVSLCSGDLGFVSAKTYDIEVWLPSYNSYKEISSCSNTTDFQTRRSNIRYRGSDNKLHYAHALNGSGLAVGRTLVAIVENYQNEDGSITVPKVLVPYMGVEKIEVK
>NC_011653.1|WP_081429720.1|504148_505594_-|site-2-protease-family-protein
MFVVIVHEFGHFLFAKIFKVSVLEFSIGFGPSIFKKKFGETVWKINIIPFGGYVRLKGEDFDESEEDGLYAKPAWQRLLIAFAGPLFSVLAAYILFIPIVLNWGVPAVTIGKVIENSPAQEYGLQPGDVIYKLNGKRIFDSYEVTNTVSKGKVVKMEILRNGEIIKKEIPPRISPPEYIFLLDDVKGDINGEIVKINGYKVGIDLKLESGTFVELEDEFGNTISGVLVQYSYVPERPTIGFYYAGFKPVVEKDMHPFKKGDIILKVNNREIDDYISLVNVITAMKLSENQVYMDIWGQQIREKIVPLGNDLNVLVSRNGKEISLNLNKKEFLNIISSPGFFKQESYVIKPKNFFDAISLAVARCNSAAISIWKAFGKLFTTGQGVEQVAGPVGIAVIVGEAAKAGWETILTVVALFTLNLGIFNLLPLPALDGGRIVFSLIEIISRKKVNRKVEAIVHTIGFFILMALAFYFMFADFSKFF
>NC_011653.1|WP_012579619.1|508264_509647_-|HD-domain-containing-protein
MLFEKCIVIFLSVSLSGVSPIFGVFFLMFLIIYYILKNSYVRFAKELEDELKILKNSMDHFQNYLELSTVNKELRISELDELKERFNYLQKVVLDNEKELQEMFYSEERLRKEVEQLNNLLVSVYDILSNIVPEEDLEEIAHKILKKLIYIIPDVNAGSIILKDGGKYRFYAQMGYSDALKDIVFTDEDYVVAVKYEGFVDGKIFKEFNEKNVFKDKIEKLGSNKIKSSYIIPIYVNNEKLGGICLDSFVNEKLVIPEYATQIFGKLFGNFLYLKLYGKRMEKLFEEILTMLVEVEEKLSNKKHSKMLANVSKIVAEKMGLDVEKVYRAAYLHDIGKIMVDKTVLKKPGRLTEKERKEIESHVKHGYELLNKFEAFKDIAEIVLYHHERCDGKGYPKGLKCEQIPIESKIISAGDVCCTLLIKGYGKEEIINLLRKDVENGKLDGNIVEILIELLRNNII
>NC_011653.1|WP_012580542.1|509636_510767_-|IS3-family-transposase
MAKKGQKFKKYPSEIKYQVVKLFIEENLPKKTIASLLGIPPDRVRLWIKNYLLYGDAERKRGKPKKESFEEEMERLRAENAYLKLLMEKILEEGNSKKKIEVINELKERFSLELLCKISGISKSTYYRAMKRKDKDEKLKEEIKDIYFKYKGIYGYRRITMVLNRKGRKINHKKVYRLMKEMGLYARIRKKNHIRKLTLDAQYIADNKLKRNFKSKRPFEKFVSDITQIKTIDGKLYLIIIQDLYNNEIIEYSIGENNNLELVNNTIKRWLKSGKYRKGGILHTDRGFQYTHVLTAKILKEKGIIQSMSRKGVPQDNGPAESFFSHLKEEVVRINGEKTKEEYKKLIEEYIRFYNEERYQARLKNMAPVEYRNHVV
>NC_011653.1|WP_012579621.1|511248_512283_+|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase
MTKEINIKNVKIGGKNSIVIQSMTNTKTEDIKSTLQQIQNLYNAGCELVRVSAPTFEAAKALKTITKESPIPVIADIHFDYKLAIESIKNGASKVRINPGNIGNDEKVKEIIKVAKEYNVPIRVGANSGSIPKELETLPKIDALCESALKEVRLLEKFDFENIVISVKSSDVIETIKAYEKISKMTDYPLHIGVTEAGTYEWAIIKSSAALGYLLYKGIGDTIRISIAGDPVKEVLAAKKLLISLNLRKGIQIIACPTCARTTIDVEKWASIIEKRFSKVEKNIKIAVLGCVVNGIGEGKDAEIGIAGVQNGFLLFYKGKIVGTFKKEEIFQVLEDYIIKVEVE
>NC_011653.1|WP_004100674.1|512260_513292_-|hypothetical-protein
MRVFLSVEELKRVLKLIDKTVGTVEKTNRIVGFKYENGFLNLYGSDGCLILKAKVSEMNPTTLSFSVPLDILKFFVFELSGNISIYSDGNYVVLKAKDENLKLKTERFSFKNFEERYEELINVPINTFVNDLDFVSSHLEEGSYVDFYFGNKVRMVAENGSIINYVVRDKKSKEYSWRIPYYSARHLIKALSEIKSGELIVGEGLNKLVLSSDYLFNVCGEELDHLDLVPLENEIEKSEEFLRVSLKSIRRFLRRAMISGRYSRLKIFGNEKGLYFYAFSENMEYRGHIDISSKYIFQTTTNAYFLRSALNRIGSETLLFFKGEKYLIISTMQKRRFILLPLL
>NC_011653.1|WP_012579622.1|513504_514641_+|dihydroorotase
MKYISVKVYDPYQKKLFYEEISLPKNIHYENLVVVPTFFDFHTHVRLLEDQEDYESLKKACIAGGFSEVLIQPNTKPRLENSNVHEKHKKLSENPYVKFYRTTSFFGFQEPNNIDILCYSTDGIEYNYNELVENFSKKKPHLLLDHSQMFEHPGIFYKKIENLPKRPVTNEAVAVARTILTGIEFGFKDFHIQHISSIYTLEMIKFLKKYANITCEVTPHHLLLTNEHIKNSNFKINPPLADQQTREFLIEAVKNNDIDILATDHAPHPDKKNDFEKAPYGTSNIEIAFSAFYTAIEDLMIVINKLCDTPRRRLKIKPKFDSENFVVVDLNQEFIVDSKKFYSKGKNCAFDGMKLKGKVVGVKINGKWGFWNGEYLLD
>NC_011653.1|WP_012579623.1|514618_515266_+|dihydroorotate-dehydrogenase
MENTYLTKKDVIQINEDTFIVTFNEKFKFDEGQFIMIQTPSLTRKPFILGTWEDNIAVSVQIKGKGTNYIVFQGEKFKAHFPLGNKFIPPAGKGIVIASPTCITLANLLHEKYSCNVLIGSKSKINLELPFESVVGNEDFSKKIKTLKTYDWYLVSGSKQMEEFVLSNIESKNVFVSLEEYMGCGIGACKSCAVFTKDGVKHVCTDGPIFRRDML
>NC_011653.1|WP_012579624.1|515262_516081_+|tRNA-dihydrouridine-synthase
MNLNPPLVIASGPGGSGEYLSLINPKYVGAYTLKTITLNPKSGNKTKRMENSENYIINSIGLENPGIEYVISNIEKFVLKETKTILSLGGDSKDEYIKIAEKIAPYAKKFEAIEFNFSCPNVKKGGLSILSDINEWQEILENVRKILPDSFLIAKLSIEGNFVEVLSKKVKEFGWNGLTLINCVRGLLIKDGKIVMGGLSGPILKPIALRAIYEVRKVLKDIYIIASGGIYTKKDVDDFLLVGANAISIGSALFKDPQVVEELGKYLKGVER
>NC_011653.1|WP_004100667.1|516077_516689_+|orotidine-5'-phosphate-decarboxylase
MIPVLSLDMEKPLEFIDKYGSFDTVKVGHNLAIFGKKILDEFEKRNIKVILDLKFCDIPSTVSRSIKSWDHPAIIGFTVHSAAGIESVKAALDSTEKIIFSVVKLTSQVGELSDYLKKIEELENIKSSFVLPGRWAINLRKKLSGKFLVPGIRMQVKADDQKDIITLDQIKDIADFAVLGREIYLSKNPKEKIEKIKEELKWK
>NC_011653.1|WP_012579625.1|516679_517246_+|orotate-phosphoribosyltransferase
MEIKEILEKTGALLTGHFLLSSGNHSEKYVQCARLFEFPEYGDMVAKMLAEKIKKYKPDLIIGPAMGGIHLAYSVSKYLNIRNIFAERENGLMTLRRGFKINKGERVAIVEDVITTGKSVKEVIDIVNESGGNLCCIGSIINRSNSNPFDVPYEYLIKLELPIYSPDECPLCKKNIPLEKPGSRFIKK

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Crispr_ID: NC_011653_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011653_6

752132-754423

Orphan

Consensus_repeat	Method
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CRISPRCasFinder
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CRT
GTTTAGAATCTACCTATGAGGAATGAAAAC	PILER-CR

32 spacers

The CRISPR arrays of NC_011653_6

>merge|NC_011653|6|752132-754423|CRISPRCasFinder,CRT,PILER-CR
TTATTTATTTTTCATAGGTAGATTCTAAACACCAAATCCTTCCATTGAAAGGCCGGTGATGTAAATTGTGTTTTTTTCTCATAGGTAGATTCTAAACTCTGGAGAGGCATTAAAACCGGTTTTTGTCAAAACAAGAGGACATGTTTTCATTCCTCATAGGTAGATTCTAAACTGAACCTGTGTTATATGCCCAACTCACTGGTAAATGTTTTCATTCCTCATAGGTAGATTCTAAACATGCAAATGAGAAATATTAAAAAAGAAATTGAAAAGAAGTATGGGTTTTCATTCCTCATAGGTAGATTCTAAACCGCAACAACAAGCAATATTGTGGGCAAGGATGGAAGAACACGTTTTCATTCCTCATAGGTATATTCTAAACGAAGGTATGTTAAAGTTACATGATAAATTACAAAACACAGTTTTCATTCCTCATAGGTAGATTCTAAACTGTTTTTTCTTCTCATGTGCTATTCCTTCTAATAGTGGTGTTTTCATTCCTCATAGGTAGATTCTAAACGTGTTTTATGTCTCTTGCTGGATCATTGAATTCCTCGGTGTTTTCGTTTTCATTCCTCATAGGTAGATTCTAAACAAGTGAATATTACCAGGGTTCGAAGCGGGCTCCTGCTTGAACCTGAAGTTTTCATTCCTCATAGGTAGATTCTAAACTGTAGACGGCTCCCCTTTAAAGCCCGTCTATATTAAGAGGTTTTCATTCCTCATAGGTAGATTCTAAACTGTATTAAGTCCCCAGGCTGGCCAAATCGGGTCTGGGATAAAATGTTTTCATTCCTCATAGGTAGATTCTAAACTCGAACTAAATTCGGGTCTGTGCAAGGATTGCCAGACCCACAAGTTTTCATTCCTCATAGGTAGATTCTAAACGAATTAGACGCGCAAGTGTACCAAGGTCCAAGAAGTTTTCATTCCTCATAGGTAGATTCTAAACGTTGTAGTTGGTTCTGGGGTAGAATGAGCAAAAGCAAGTTTTCATTCCTCATAGGTAGATTCTAAACAAGACGCGATTTTCGCGTATTGGAGGCATCCGAGAGCCTTTGCGTTTTCATTCCTCATAGGTAGATTCTAAACGATAAAGAGGGAAGTAACATTTTATTTAGATTTGCACAATTTGTTTTCATTCCTCATAGGTAGATTCTAAACAATAATCGCAGATGACGACGATGAGGAAGACAACGATGGTTTTCATTCCTCATAGGTAGATTCTAAACGAAAAAGAATCGCTACAGACATGGCAAAAAGCATTGGGTTTTCATTCCTCATAGGTAGATTCTAAACTAACCGAAAAAGAATTGAGGCAAATGATAAACAACAAAATTAAAGTTTTCATTCCTCATAGGTAGATTCTAAACCAATATCCCGCTTGAGGAATACATCAGAAAATTCATTCAGTTTTCATTCCTCATAGGTAGATTCTAAACTAATCAGGGACCCAGATGTATGGGGGGCTCCCTGGGAGTGTGTTTTCATTCCTCATAGGTAGATTCTAAACGAAATAAAACAATTCAACGAAAAAATCCTTGATGCCCGTTTTCATTCCTCATAGGTAGATTCTAAACAGAAAAGAAAGGAGCTGATAGAATGTGTAGACTACTTGGTTTTCATTCCTCATAGGTAGATTCTAAACAAAGGTAAAGAGATTTGGGGGGTTTTTGAAACCAAGAAATACAAGTTTTCATTCCTCATAGGTAGATTCTAAACGGAGAAATTATGAGGAAAATTTACGAATCAAAAAAGGTAGATAAGTTTTCATTCCTCATAGGTAGATTCTAAACACGAAGGCTATGACGATGAAGAAGAGGATTATTAATAGTTTTCATTCCTCATAGGTAGATTCTAAACCGATGCAATGCCTGGAGCTGCTGCAAGTGCTGCTAATAGTTTTCATTCCTCATAGGTAGATTCTAAACGATTTACGAAGTGCAATTAATACTGTTATAGAACCGTTAACAGTTTTCATTCCTCATAGGTAGATTCTAAACGCATCATTACAACTTGGTATGGGAATATGCAAAAGCGTTCAAGTTTTCATTCCTCATAGGTAGATTCTAAACACATTACCTTTAAAGCTAATACATGGCGTTAGTAAAAGCACACGTTTTCATTCCTCATAGGTAGATTCTAAACAAAGATTATCGTGAAATTCAACAACGAAATGGAAAAAAGTTTTCATTCCTCATAGGTAGATTCTAAACCGAATAATAATAATCGACAACAGATTATTCTGTGATTGGAAAATCAGTTTTCATTCCTCATAGGTAGATTCTAAAC

>NC_011653|6|6|752132-754423|CRISPRCasFinder
TTATTTATTTTTCATAGGTAGATTCTAAAC	ACCAAATCCTTCCATTGAAAGGCCGGTGATGTAAATT
GTGTTTTTTTCTCATAGGTAGATTCTAAAC	TCTGGAGAGGCATTAAAACCGGTTTTTGTCAAAACAAGAGGACAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAACCTGTGTTATATGCCCAACTCACTGGTAAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATGCAAATGAGAAATATTAAAAAAGAAATTGAAAAGAAGTATGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CGCAACAACAAGCAATATTGTGGGCAAGGATGGAAGAACAC
GTTTTCATTCCTCATAGGTATATTCTAAAC	GAAGGTATGTTAAAGTTACATGATAAATTACAAAACACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTTTTTTCTTCTCATGTGCTATTCCTTCTAATAGTGGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GTGTTTTATGTCTCTTGCTGGATCATTGAATTCCTCGGTGTTTTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAGTGAATATTACCAGGGTTCGAAGCGGGCTCCTGCTTGAACCTGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTAGACGGCTCCCCTTTAAAGCCCGTCTATATTAAGAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTATTAAGTCCCCAGGCTGGCCAAATCGGGTCTGGGATAAAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCGAACTAAATTCGGGTCTGTGCAAGGATTGCCAGACCCACAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAATTAGACGCGCAAGTGTACCAAGGTCCAAGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GTTGTAGTTGGTTCTGGGGTAGAATGAGCAAAAGCAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAGACGCGATTTTCGCGTATTGGAGGCATCCGAGAGCCTTTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GATAAAGAGGGAAGTAACATTTTATTTAGATTTGCACAATTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AATAATCGCAGATGACGACGATGAGGAAGACAACGATG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAAAAGAATCGCTACAGACATGGCAAAAAGCATTGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TAACCGAAAAAGAATTGAGGCAAATGATAAACAACAAAATTAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAATATCCCGCTTGAGGAATACATCAGAAAATTCATTCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TAATCAGGGACCCAGATGTATGGGGGGCTCCCTGGGAGTGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAATAAAACAATTCAACGAAAAAATCCTTGATGCCC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AGAAAAGAAAGGAGCTGATAGAATGTGTAGACTACTTG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAAGGTAAAGAGATTTGGGGGGTTTTTGAAACCAAGAAATACAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGAGAAATTATGAGGAAAATTTACGAATCAAAAAAGGTAGATAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACGAAGGCTATGACGATGAAGAAGAGGATTATTAATA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CGATGCAATGCCTGGAGCTGCTGCAAGTGCTGCTAATA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GATTTACGAAGTGCAATTAATACTGTTATAGAACCGTTAACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCATCATTACAACTTGGTATGGGAATATGCAAAAGCGTTCAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACATTACCTTTAAAGCTAATACATGGCGTTAGTAAAAGCACAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAAGATTATCGTGAAATTCAACAACGAAATGGAAAAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CGAATAATAATAATCGACAACAGATTATTCTGTGATTGGAAAATCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC

>NC_011653|6|6|752132-754423|CRT
TTATTTATTTTTCATAGGTAGATTCTAAAC	ACCAAATCCTTCCATTGAAAGGCCGGTGATGTAAATT
GTGTTTTTTTCTCATAGGTAGATTCTAAAC	TCTGGAGAGGCATTAAAACCGGTTTTTGTCAAAACAAGAGGACAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAACCTGTGTTATATGCCCAACTCACTGGTAAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATGCAAATGAGAAATATTAAAAAAGAAATTGAAAAGAAGTATGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CGCAACAACAAGCAATATTGTGGGCAAGGATGGAAGAACAC
GTTTTCATTCCTCATAGGTATATTCTAAAC	GAAGGTATGTTAAAGTTACATGATAAATTACAAAACACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTTTTTTCTTCTCATGTGCTATTCCTTCTAATAGTGGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GTGTTTTATGTCTCTTGCTGGATCATTGAATTCCTCGGTGTTTTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAGTGAATATTACCAGGGTTCGAAGCGGGCTCCTGCTTGAACCTGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTAGACGGCTCCCCTTTAAAGCCCGTCTATATTAAGAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTATTAAGTCCCCAGGCTGGCCAAATCGGGTCTGGGATAAAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCGAACTAAATTCGGGTCTGTGCAAGGATTGCCAGACCCACAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAATTAGACGCGCAAGTGTACCAAGGTCCAAGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GTTGTAGTTGGTTCTGGGGTAGAATGAGCAAAAGCAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAGACGCGATTTTCGCGTATTGGAGGCATCCGAGAGCCTTTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GATAAAGAGGGAAGTAACATTTTATTTAGATTTGCACAATTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AATAATCGCAGATGACGACGATGAGGAAGACAACGATG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAAAAGAATCGCTACAGACATGGCAAAAAGCATTGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TAACCGAAAAAGAATTGAGGCAAATGATAAACAACAAAATTAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAATATCCCGCTTGAGGAATACATCAGAAAATTCATTCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TAATCAGGGACCCAGATGTATGGGGGGCTCCCTGGGAGTGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAATAAAACAATTCAACGAAAAAATCCTTGATGCCC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AGAAAAGAAAGGAGCTGATAGAATGTGTAGACTACTTG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAAGGTAAAGAGATTTGGGGGGTTTTTGAAACCAAGAAATACAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGAGAAATTATGAGGAAAATTTACGAATCAAAAAAGGTAGATAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACGAAGGCTATGACGATGAAGAAGAGGATTATTAATA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CGATGCAATGCCTGGAGCTGCTGCAAGTGCTGCTAATA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GATTTACGAAGTGCAATTAATACTGTTATAGAACCGTTAACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCATCATTACAACTTGGTATGGGAATATGCAAAAGCGTTCAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACATTACCTTTAAAGCTAATACATGGCGTTAGTAAAAGCACAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAAGATTATCGTGAAATTCAACAACGAAATGGAAAAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CGAATAATAATAATCGACAACAGATTATTCTGTGATTGGAAAATCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC

>NC_011653|6|10|752274-754423|PILER-CR
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGAACCTGTGTTATATGCCCAACTCACTGGTAAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATGCAAATGAGAAATATTAAAAAAGAAATTGAAAAGAAGTATGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CGCAACAACAAGCAATATTGTGGGCAAGGATGGAAGAACAC
GTTTTCATTCCTCATAGGTATATTCTAAAC	GAAGGTATGTTAAAGTTACATGATAAATTACAAAACACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTTTTTTCTTCTCATGTGCTATTCCTTCTAATAGTGGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GTGTTTTATGTCTCTTGCTGGATCATTGAATTCCTCGGTGTTTTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAGTGAATATTACCAGGGTTCGAAGCGGGCTCCTGCTTGAACCTGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTAGACGGCTCCCCTTTAAAGCCCGTCTATATTAAGAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TGTATTAAGTCCCCAGGCTGGCCAAATCGGGTCTGGGATAAAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TCGAACTAAATTCGGGTCTGTGCAAGGATTGCCAGACCCACAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAATTAGACGCGCAAGTGTACCAAGGTCCAAGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GTTGTAGTTGGTTCTGGGGTAGAATGAGCAAAAGCAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAGACGCGATTTTCGCGTATTGGAGGCATCCGAGAGCCTTTGC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GATAAAGAGGGAAGTAACATTTTATTTAGATTTGCACAATTT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AATAATCGCAGATGACGACGATGAGGAAGACAACGATG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAAAAGAATCGCTACAGACATGGCAAAAAGCATTGG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TAACCGAAAAAGAATTGAGGCAAATGATAAACAACAAAATTAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAATATCCCGCTTGAGGAATACATCAGAAAATTCATTCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TAATCAGGGACCCAGATGTATGGGGGGCTCCCTGGGAGTGT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GAAATAAAACAATTCAACGAAAAAATCCTTGATGCCC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AGAAAAGAAAGGAGCTGATAGAATGTGTAGACTACTTG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAAGGTAAAGAGATTTGGGGGGTTTTTGAAACCAAGAAATACAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGAGAAATTATGAGGAAAATTTACGAATCAAAAAAGGTAGATAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACGAAGGCTATGACGATGAAGAAGAGGATTATTAATA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CGATGCAATGCCTGGAGCTGCTGCAAGTGCTGCTAATA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GATTTACGAAGTGCAATTAATACTGTTATAGAACCGTTAACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GCATCATTACAACTTGGTATGGGAATATGCAAAAGCGTTCAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACATTACCTTTAAAGCTAATACATGGCGTTAGTAAAAGCACAC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AAAGATTATCGTGAAATTCAACAACGAAATGGAAAAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CGAATAATAATAATCGACAACAGATTATTCTGTGATTGGAAAATCA
GTTTTCATTCCTCATAGGTAGATTCTAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011653.1\|WP_148203267.1\|760505_761006_-\|transposase	unknown	unknown	gnl\|CDD\|376573
NC_011653.1\|WP_012579772.1\|761308_761971_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200557
NC_011653.1\|WP_012579774.1\|762555_763053_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|275030
NC_011653.1\|WP_004104694.1\|750936_751842_+\|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl\|CDD\|235439
NC_011653.1\|WP_012579758.1\|740495_741278_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|224997
NC_011653.1\|WP_012579773.1\|761973_762498_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012580547.1\|741368_742628_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_011653.1\|WP_012579759.1\|742987_743959_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NC_011653.1\|WP_012579762.1\|747003_748299_+\|amidophosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223112
NC_011653.1\|WP_041427191.1\|759139_760333_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340828
NC_011653.1\|WP_012579768.1\|755704_757123_-\|oligosaccharide-flippase-family-protein	unknown	unknown	gnl\|CDD\|240533
NC_011653.1\|WP_012579765.1\|749746_750940_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|223229
NC_011653.1\|WP_012579769.1\|757157_758180_-\|polysaccharide-pyruvyl-transferase-family-protein	unknown	unknown	gnl\|CDD\|377253
NC_011653.1\|WP_012579761.1\|745435_746482_+\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012579760.1\|744055_745414_+\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240552
NC_011653.1\|WP_012579776.1\|764949_765705_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012579767.1\|754473_755676_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340828
NC_011653.1\|WP_012579763.1\|748262_748820_+\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|187714
NC_011653.1\|WP_012579764.1\|748843_749737_+\|phosphoribosylaminoimidazolecarboxamide-formyltransferase	unknown	unknown	gnl\|CDD\|223216
NC_011653.1\|WP_012579770.1\|758176_759133_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154

Protein	Function_ID	Function_description	E-value
NC_011653.1\|WP_148203267.1\|760505_761006_-\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	0.00428589
NC_011653.1\|WP_012579772.1\|761308_761971_-\|hypothetical-protein	gnl\|CDD\|200557	cd10931, CE4_u7, Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily. This family corresponds to a group of uncharacterized bacterial proteins with high sequence similarity to the catalytic domain of the six-stranded barrel rhizobial NodB-like proteins, which remove N-linked or O-linked acetyl groups from cell wall polysaccharides and belong to the larger carbohydrate esterase 4 (CE4) superfamily.	1.47357e-45
NC_011653.1\|WP_012579774.1\|762555_763053_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|275030	TIGR04176, hypothetical_protein, EPS-associated transcriptional regulator, MarR family. Members of this family of MarR-family transcriptional regulators are associated with long genomic loci consisting of genes encoding enzymes for the biosynthesis of exopolysaccharides. These genes include glycosyl transferases, sugar modifying enzymes (epimerases, isomerases, methyltransferases, aminotransferases, etc.), and exopolysaccharide polymerases (wzx, wzy). In Leptospira interrogans, borgpeterenii and biflexa, this gene is observed first in unidirectional EPS biosynthesis loci as long as 90 genes. MarR genes (pfam01407) are known to bind to DNA regions with palindromic or pseudopalindromic sequences as homodimers, and to bind small molecules as triggers for conformational changes controlling on/off states.	4.75252e-20
NC_011653.1\|WP_004104694.1\|750936_751842_+\|phosphoribosylformylglycinamidine-cyclo-ligase	gnl\|CDD\|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	8.83663e-104
NC_011653.1\|WP_012579758.1\|740495_741278_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	5.76805e-89
NC_011653.1\|WP_012579768.1\|755704_757123_-\|oligosaccharide-flippase-family-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	3.01053e-24
NC_011653.1\|WP_012579759.1\|742987_743959_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	5.15465e-131
NC_011653.1\|WP_012579762.1\|747003_748299_+\|amidophosphoribosyltransferase	gnl\|CDD\|223112	COG0034, PurF, Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism].	0
NC_011653.1\|WP_041427191.1\|759139_760333_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340828	cd03798, GT4_WlbH-like, Bordetella parapertussis WlbH and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.	7.40784e-94
NC_011653.1\|WP_012579765.1\|749746_750940_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|223229	COG0151, PurD, Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism].	6.24588e-134
NC_011653.1\|WP_012579769.1\|757157_758180_-\|polysaccharide-pyruvyl-transferase-family-protein	gnl\|CDD\|377253	pfam04230, PS_pyruv_trans, Polysaccharide pyruvyl transferase. Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.	1.10605e-26
NC_011653.1\|WP_012580547.1\|741368_742628_+\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	3.27966e-31
NC_011653.1\|WP_012579760.1\|744055_745414_+\|MATE-family-efflux-transporter	gnl\|CDD\|240552	cd13147, MATE_MJ0709_like, Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	0
NC_011653.1\|WP_012579767.1\|754473_755676_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340828	cd03798, GT4_WlbH-like, Bordetella parapertussis WlbH and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.	3.80529e-97
NC_011653.1\|WP_012579763.1\|748262_748820_+\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|187714	cd08645, FMT_core_GART, Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART). Phosphoribosylglycinamide formyltransferase, also known as GAR transformylase or GART, is an essential enzyme that catalyzes the third step in de novo purine biosynthesis. This enzyme uses formyl tetrahydrofolate as a formyl group donor to produce 5'-phosphoribosyl-N-formylglycinamide. In prokaryotes, GART is a single domain protein but in most eukaryotes it is the C-terminal portion of a large multifunctional protein which also contains GAR synthetase and aminoimidazole ribonucleotide synthetase activities.	1.18392e-82
NC_011653.1\|WP_012579764.1\|748843_749737_+\|phosphoribosylaminoimidazolecarboxamide-formyltransferase	gnl\|CDD\|223216	COG0138, PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism].	1.10121e-106
NC_011653.1\|WP_012579770.1\|758176_759133_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	2.65833e-18

>NC_011653.1|WP_004104694.1|750936_751842_+|phosphoribosylformylglycinamidine-cyclo-ligase
MKYTYKQAGVDVKKGDEFAKIIKENVNIPEWILKEPTGYATVLLFTTPPIAVTADGIGTKILLHIEHGTFKEAAKDLIAMNYNDLICVGAKPIAFLDYIGTHKIGEIEKKFIDALIKELKNCDMYLVAGETAEMPDMYQENHFDVAGFAIGTLIKKFEHSHIKPGDYIMALDSSGFHSNGWSLIRKIISEEKINIKDLPFDILKGTRIYKEIIPYFDKIKAMAHVTGGGITRALRRLLGNLGYEINIEKKEFVDWILKYVEFDEAINTFNMGYGLLYVSETDELPGKVVGRVKESERVIKF
>NC_011653.1|WP_012579765.1|749746_750940_+|phosphoribosylamine--glycine-ligase
MKVCIVGSGGREHAMGYAFEKAGFEVFYTPGNGLTENNIDFESLKYFNGLIIPGSEEYLANGIAEKYANVFGPDSRASRLESSKIYAKQFMSIYNLTTPMFEIASNREELLEKIEKFYPPYVLKADGLAKGKGVLIVENKDEAVELGSKLISGELIAGVSGPIVIDEFLPGRELSAMAVVNGDNFSLFPFIQDYKKINTGNTGPNTGGMGSFGPIEIDGELKTKIEELFAKTLYGLKKEGVFYRGFLYLGLMIYEKTPYILEYNVRLGDPETEVIVATNPDNFVECVLKAYNKENIPEFNPKYYALDVVLASKGYPGKYEKGKEIRNLFPLQGEDFVIFGAGVKKENDKYYTNGGRVLHCVAFSENKEEAKKRAYEISEKIDFDGKIFRKDIGVIYA
>NC_011653.1|WP_012579764.1|748843_749737_+|phosphoribosylaminoimidazolecarboxamide-formyltransferase
MYLEKFDLDLRYGENSHEKAEIFGKPAFEILHEGKQLSYNNILDAEAAYVIANNLKKLKGYASVVVKHQTPCGASIKNDKIESILSAIAADEESSFGGILAVNFEFDEKCAMAIKKKYLEVVVAESFTQEAIEALSKKKVRILKINDYEPKVGKPAFGAFLVGERKLPDLKFTHVAGPQLDVEELNELLFAFIVVEGVKSNAILISKDMTTVGIGTGQPSRKRAAWIATELAGEKAKDAYVASDAFFPFPDGLEILAKAGVKAVVSPMGSIRDEEVINAAEKMGLSFYKAEGRVFRH
>NC_011653.1|WP_012579763.1|748262_748820_+|phosphoribosylglycinamide-formyltransferase
MPGMSQSKLPRIVVLASGNGSNFEAIVKAQREGKLRAEILMLVVNKECFAIERAKRLGISYKKLSKDWKGELFALLEELSPDLVVLAGFMKILPPNIVNKWKIVNIHPSLLPAFKGKDAIKQAYEYGVKVTGITIHYVDEGVDTGPIIFQHAINIDGMSFEEVEEEIHKIEHKYYPIIIDKILND
>NC_011653.1|WP_012579762.1|747003_748299_+|amidophosphoribosyltransferase
MCGIAGVWNVEKSYNVLHDLLLGLQHRGQESVGIVLEDFKMIKNKGLVSQVLSESNFLPGNSGIGHVRYSTYGSNTEIQPLIGITSKGKFAIAHNGNIPDAESRINSLVEKGSVFNSTLDTEIFLHYISLAPYSDPILSIQWAFSRISSAYSVVILGKDKLIAARDRFGFRPLFYGKYKNGYVIASEDSVLYSIGANKIVEVLPGEIVIFSDSGIEKVKYANTDVKFCSFEYIYFSRPDSNFLYGNVHRARYRMGEILFEESSMRGDIVIPILDSGFSGALGFSAASKIPIELGLMRNRYLGRSFIMPENREEIIKRKLVPIPEVIKDKEVIIIDDSIVRGTTMKQIVKMLKENGARKVKVGIHSPPVIGPCPYGIDTSRKNELIANQKSIDEILSEINADELHYLSVEGLKKAIGGDNLCLGCLNLNYPV
>NC_011653.1|WP_012579761.1|745435_746482_+|hypothetical-protein
MEFTIRIDELNNKLKSKFFIVILSNEENLKKCVENNIAGFPETDNGVWAYLDINEGDYVSFYYNGRIFNLYKVEKKFIPEHYKKSNNSIGNEMYDPVPLNNGDKWRAISTKKGNLYFPYRLSLKLLEKTDFLTSLVFKSGFERFGINLIPRVSLKKSHFQLSLSDINKIFGIENLSVSLSSFTLKDFAEVFSKNKRINKEKFSVENIVDKEIFLQTLIKRILEASIYKYKKVVFDKISFGNDSFEFFSEQTVYGGEADIVIAYNSENIAFVEVKNGIILKKNGEFTRIGSEAYDQVKSYKDIIDPNKKIRKIIAGKKDFGSKDVLLKIFEKKSENIMVFEVNSSFEIL
>NC_011653.1|WP_012579760.1|744055_745414_+|MATE-family-efflux-transporter
METKGVKLLQGDPKRAIVKLSIPMIFAMLVQTMYNLVDGIWVAGLGPAALAAIGAFFPIFMIIISLASGLGVGASSVIARKIGEKNKNEADKAAVNSLAIAVIFGLTFMIVSLALIKPVLEVLGTSKEVLDETLKYAYIVIFSIPLLMFNNVSNGILRGEGDAKKAMYAISIGSILNIFLDPLFIYTFKLGIKGAAYATVFSILVSAILIVFWLFIKKDTYVSIHIKGMKLEAKIINDILRVGIPSSIAQIAMSVAMFVLNVFAVKAGKDLGIAVFTSAWRIINFGTVPLIGIATAVTSVTGAAFGQRDAKKLKTAYLYAIRFGEIISLVVMSSILIFANYIAKAFTYSENGAQIYSELVNALRILSLFLPGVPFGMFTSSMFQGTGYGIRSMIVSINRTIIMQVLFSYLYVFVFNIGLNGVWWGIVTGNAISAAITFTWGIFTVKNIKRKF
>NC_011653.1|WP_012579759.1|742987_743959_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MKEIWVYIETFNKKVKKVSLELLTKANELSQKLSAKVVAVYIDKDDLDDTISKYGADKIVHLYNKDLQFYDSQIYTNALYNLIKDDRPHILLIGATSVGRDLAPRLAAKLNTGLTADCTQLDLDEDGLLLQTRPAFGGNIMATIICPEHIPQMATVRPGIFDAKKLEKIPEIEKIEFELEKNCTTKTLEIMKKNSLLKDITESDVIVAGGRGLSKKEGFDLLRDLAKELNGTIAASRAAVEAGWAPQEIQVGQTGKTVKPKIYIACGISGAIQHIAGMKDSKCIIAINKDKNAPIFKIADYAIVGDVYEVVPKLIEKLRVLKQ
>NC_011653.1|WP_012580547.1|741368_742628_+|IS110-family-transposase
MKQKSINKKISRITQDTLIVGIDVAKRTHWIRMMDFRGIDLIKPFKINNTMDGIKMLEEKIKSVKEENKLNKVVLGMEPSGHYWKVLAWQMKISKEIDYLVGVNPYHVKKSKEFDDNSPGKSDRKDAGVIARLIRDGRYFDIYLPEDIYGELRVITTTREQLVNKRKNAKNMVISVMDEYFPEYEKIYKNIFSEGSIKLLKTHPFPKEIIEVGIEEIEKVLKKSTNGKDWKSRAQKIYESAKKSIGVREGQKSAKIKLRMLLEEIEFLTSQIEELEKEMEELVEETEEGEYIKSVPGIGPIMTAVILGEIGDINRFKSWKEIRKLAGLNLYEISSGEHKGKTRITKRGRPLLRKIIYLMAQTTLKHNHEIRKKYEQLRRREKNPLKVVQALIAIGLKMIRIVFKLAKSKIKYEPEKVYV
>NC_011653.1|WP_012579758.1|740495_741278_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MNIVVCIKQVPDTTELKIDPITGTLIRKGVPSIMNYDDKAALEEALKLKDQIGAKVTAISMGPEQAKEVLEEALAMGADDAILISDKVFSGSDTWATSNVLSEAIKKIGFDVIFTGRQAIDGDTAQVGPQIAQKLGIPQVTYVRKLSYKEGKFLIEREMDDYIEIMEARPPVLFSVVKEANNPRYLDVRRLVDICQKDPIQIWNNNDLKIDESIIGLKGSPTKVKKTFTPTFEKETKVIEGSTDEKVQTLIKELKEKHLI
>NC_011653.1|WP_012579767.1|754473_755676_-|glycosyltransferase-family-4-protein
MKPLILTNLFPRKDNPNSGIFITKRLKEYQKLGVDFTAVSLAFRDKGRLLNLLRSLLHKPSEIPLEELEGVSFNPVFVERWLFDVAVQKLWTMKKALENFTDRFAEKISREFPKHNIIHAHGMYLPAPAGVVARKVSEIWNVPYVVTLHGSDVNLNMARRDMRNIYLETLENAARCIFVSRALLEKAKSFGYSGQNAVVIPNGYDPEIFKPIDKDTVRKELGIYKENTHYVGFVGNLIPIKRADKLPEIFGKISKELPNSRFIIVGDGTLRDKILKEMEGLDVVFAGRVPQVKVARYMNAMDVMVLPSRNEGWPCVVLEAQACGTCVIGSSNGGIPEAIGFDEYVVEEGESFEDRFAKRVVEVLKKGYNKNILIERAKSFNWEKTVKREIEVYYQAPWPM
>NC_011653.1|WP_012579768.1|755704_757123_-|oligosaccharide-flippase-family-protein
MKQYRKLAINTFLFAIGNVGSRSISFLLLPLFTRYMVPSDYGKLDVINTTVSLLVPLLSFQIIEATFRFAADVKETGKGKNVFSSAFLFSFLSFLFSVCLYPLLRNIDIFAEFSLYFYSIFFLTVLNGVVKQFVRGLEKIKLYVISDILYSGVFAGSNIILLVVMKLGIRAYLLSNIVALLSSILFIFFSAGLVKYLSPRIDSKTLKEMLSYSIPLIPNGIMWWMVNASDRYFLSYFIGYEATGMYSVASRFPSLITTLYAVFFQAWQLSAIEEFGKEGYGRFFKNVFGMLSSVMFLGSSILFLLIKPFMRVYVGATYFESWKYTVFLFLGAVFNTFASFYGVNYTASKRTAGAFSTSVIAATTKVAVVLSLIKILRIQAASISTFLAYFVMWIVRIFHTRKIVKVELDVKHIVSSSAIVITQAIFLLMIESTVLLYVLQAVLLTILLWSQREYISKAFRFGRSLLGSKAKK
>NC_011653.1|WP_012579769.1|757157_758180_-|polysaccharide-pyruvyl-transferase-family-protein
MKTLLVAIVGNDNFGDEAMFKAIYRKLLSRGEEIVVATYNVDEAKRRFPNVNFIKIPILSKHQYLLGLMGKNVLSIDISRFDSLYISGGGTLNSLYPLHVFNIYLMVREFRKKRKYVEFRPQSVGPFFGRTKPILEFLIKRIVKFSDKFYVREQASYEYLAKKNLKIELHRDDAWEIPADSSISLPDGKYVGLCIRPWKRQEDLLREYMKELVKEIEKLNYIPLFIPIAYGGSESYIDNAFLKGIVPGIFLDDLIEMDSLTPETIKDIIGRCCFTIGMSYHFNVFSLSQGVPSAAIYLDEYYKIKNLGLYKAFGNPKLVFKIPETPPSELLRTILEISNI
>NC_011653.1|WP_012579770.1|758176_759133_-|glycosyltransferase-family-2-protein
MAPIKLLVGIPTLNRADQLKNTLHSILRNTVLPQKIIIVDQSENEKTKHIVNYFREKLNIEYLNVNYKGLTKARNEILSYAKDFDVVTFLDDDVELDKNYFEEIVKAFQEDKNLAGCQGFIENQGGIKGFLFRLAEGMPLTGSPKVTNCFVNTYPFFPPSRPVISEWLSGCNMSYRVDYIEKEKFNENFILYGLGEDLEFSYRLFVSGKRLLMLPSARLKHIPSGLKRLPSRVAVMMRLAYRRYMIAKYRSQVDMLFQEYVEWCRRTFRIHRIVRPQLWKSMMKTIEEVLNELKSHFDMIDKGDLNSVNSLILKEVSM
>NC_011653.1|WP_041427191.1|759139_760333_-|glycosyltransferase-family-4-protein
MKILILTNLFPKKENPNSGIFITKRLKEHEKLGVDFTAVSLAFRDKGRLLSLLRSLLRKPSEVPLKELEGVSFKPVFVERGLFDVVVQKFWTMKRALENLTDRFAEQVVQNFPKHTVIHAHGMYLPAPAGVVARKVSEIWNVPYVVTLHGSDVNLNMARRDVRDIYLETLENAARCIFVSRALLEKAKSFGYSGQNATVIPNGYDPDVFKPMDKNTVIKELGIYKEDTQYVGFVGNLIPIKRADKLPEIFRKIAKELPNTRFLIVGNGVLRDKILKEMEGLDVIFAGRVPQVEVAKYMNAMNVMVLPSRNEGWPCVVLEAQACGTCVVGSSNGGIPEAIGFDEYVVEEGENFEERFAKRVVDVLKKGYDRDRLIERAKGFTWEEIVKREISILNKVV
>NC_011653.1|WP_148203267.1|760505_761006_-|transposase
MSKKLKKLFGTLLVIDSTEIKDRYTRLHVLYEAKEKVLIDFKIGEYSETEQAELLLEEVENSILLADRGYWVWRFLERVKDRMRLYVRPRGKEGKKFLKSELNRYIYSKRWEIEWFIERMKQRMKLKGMNEKTLKAQITYMLLGMQLTFLIDTLIHHPKLFRFIDS
>NC_011653.1|WP_012579772.1|761308_761971_-|hypothetical-protein
MDKIIKKLKQIDPFSVFNLIEIHKKYGTTGTFFFLPDNQPKKFGNGYKLHRNIKHLQLLEKEIMAINGSIGIHYDARYLEENRMKNDLDNLKNVFSSIMEAGRAHYLLFDITKSFKILENSGIKIDTTCSYADRVGFRFGTCKPFNPYNFEKNREYGLLEIPLVVMDGTLQSKKYMGLTPKEGLKKIKELINKTIRYKGTLANVTEKVERVKVEKRATPQ
>NC_011653.1|WP_012579773.1|761973_762498_-|hypothetical-protein
MKNETINIHPLDVKNYIEKHLNNIFEENIKIDVDEKRNTYIINKIKEVEIYDFWNKEDEELLKDFENYSFKGDCIGTIFFFLSGFWEYTHTYLKDNFGRFPAIESFQYKKNVLEEPVADILIDKLSKELNLTYKNFYTRKNVFITHDVDILQGFKGFRFMRSLVGDVLKRKKYL
>NC_011653.1|WP_012579774.1|762555_763053_-|winged-helix-turn-helix-transcriptional-regulator
MEDNKIKLLEIIYENPGITQREIAKRTGLSLGLVNLLLKKFVRKGLIKLEKLNKKTFKYILTPKGFAEKAKKTIQYIRIYYEKIKQIKVKVEKIVKENGKDKIYAIYGEDEFIINVVREVLKNLKVKYVIYDKTDEITQTQDMIILYWDVEKSNILKDLRSFLVL
>NC_011653.1|WP_012579776.1|764949_765705_-|hypothetical-protein
MVYLNVFKGTVLRVISELKRYYLNTISFFTIMTMLFYFMVLGITKFGNPANLGESIQALAIGYIVWFTFLGTITDLSWTIINEMSIGLIEQAFISPVGPSTIYLFYQFSNFLIMIPFEFLILIVVFKIAGIPLIIPMSFIITLILLMLQGYGIGLILAGITLRFKRTQALLNIAQFAIIGLLLGDYKGIVKYIVPANGYMKILSNLIEGSSVRFNDWIYMITSSLLYIFVGIILFNYFADVVRKRGEISQY

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Crispr_ID: NC_011653_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011653_7

763252-763826

Orphan

Consensus_repeat	Method
GTTTAGAATCTACCTATGAGGAATGAAAAC	PILER-CR
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CRISPRCasFinder
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CRT

8 spacers

The CRISPR arrays of NC_011653_7

>merge|NC_011653|7|763252-763826|PILER-CR,CRISPRCasFinder,CRT
GTTTTCATTCCTCATAGGTAGATTCTAAACTTGTTGTCCTTGAACGACAGGATCGAATAGAGCTTGAGTTTTCATTCCTCATAGGTAGATTCTAAACCAGTAAAGAGCACGCAGAAGAAGTAATTATTATACACAGGTTTTCATTCCTCATAGGTAGATTCTAAACCACTAAAAGCATTGCTAAGGATTATGCAGACTATGACGAGTTTTCATTCCTCATAGGTAGATTCTAAACATTTATGATGTAATTGACGGTACTTCTTCCATAAGTAAAGGTTTTCATTCCTCATAGGTAGATTCTAAACATCATTAATACCAAAATGAAGATAAAGGAGGGACTCGGTTTTCATTCCTCATAGGTAGATTCTAAACCTTTACCCAGTTGAGAAGGTGAATTATGCTGATGATTGTTTTCATTCCTCATAGGTAGATTCTAAACTTATTCGAGAAATTGGGAACCACATTATGTACCAATGTTTTCATTCCTCATAGGTAGATTCTAAACAGGAAGAAGTGATAGTAATACACACCAAAGACCAACTAAAGTTTTCATTCCTCATAGGTAGATTCTAAAC

>NC_011653|7|11|763252-763826|PILER-CR
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTGTTGTCCTTGAACGACAGGATCGAATAGAGCTTGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAGTAAAGAGCACGCAGAAGAAGTAATTATTATACACAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CACTAAAAGCATTGCTAAGGATTATGCAGACTATGACGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTATGATGTAATTGACGGTACTTCTTCCATAAGTAAAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATCATTAATACCAAAATGAAGATAAAGGAGGGACTCG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTTTACCCAGTTGAGAAGGTGAATTATGCTGATGATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTATTCGAGAAATTGGGAACCACATTATGTACCAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AGGAAGAAGTGATAGTAATACACACCAAAGACCAACTAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC

>NC_011653|7|7|763252-763826|CRISPRCasFinder
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTGTTGTCCTTGAACGACAGGATCGAATAGAGCTTGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAGTAAAGAGCACGCAGAAGAAGTAATTATTATACACAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CACTAAAAGCATTGCTAAGGATTATGCAGACTATGACGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTATGATGTAATTGACGGTACTTCTTCCATAAGTAAAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATCATTAATACCAAAATGAAGATAAAGGAGGGACTCG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTTTACCCAGTTGAGAAGGTGAATTATGCTGATGATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTATTCGAGAAATTGGGAACCACATTATGTACCAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AGGAAGAAGTGATAGTAATACACACCAAAGACCAACTAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC

>NC_011653|7|7|763252-763826|CRT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTGTTGTCCTTGAACGACAGGATCGAATAGAGCTTGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CAGTAAAGAGCACGCAGAAGAAGTAATTATTATACACAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CACTAAAAGCATTGCTAAGGATTATGCAGACTATGACGA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATTTATGATGTAATTGACGGTACTTCTTCCATAAGTAAAG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ATCATTAATACCAAAATGAAGATAAAGGAGGGACTCG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CTTTACCCAGTTGAGAAGGTGAATTATGCTGATGATT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTATTCGAGAAATTGGGAACCACATTATGTACCAAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AGGAAGAAGTGATAGTAATACACACCAAAGACCAACTAAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011653.1\|WP_148203267.1\|760505_761006_-\|transposase	unknown	unknown	gnl\|CDD\|376573
NC_011653.1\|WP_012579772.1\|761308_761971_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200557
NC_011653.1\|WP_012579774.1\|762555_763053_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|275030
NC_011653.1\|WP_004104694.1\|750936_751842_+\|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl\|CDD\|235439
NC_011653.1\|WP_012579773.1\|761973_762498_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012579768.1\|755704_757123_-\|oligosaccharide-flippase-family-protein	unknown	unknown	gnl\|CDD\|240533
NC_011653.1\|WP_012579776.1\|764949_765705_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012579779.1\|767880_768783_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_041427191.1\|759139_760333_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340828
NC_011653.1\|WP_012579783.1\|772384_773362_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213028
NC_011653.1\|WP_012579769.1\|757157_758180_-\|polysaccharide-pyruvyl-transferase-family-protein	unknown	unknown	gnl\|CDD\|377253
NC_011653.1\|WP_012579784.1\|773375_774497_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NC_011653.1\|WP_012579781.1\|770804_771431_+\|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|185680
NC_011653.1\|WP_012579782.1\|771420_772311_+\|tRNA-dihydrouridine-synthase-family-protein	unknown	unknown	gnl\|CDD\|239200
NC_011653.1\|WP_012579780.1\|768775_769150_-\|DUF2089-domain-containing-protein	unknown	unknown	gnl\|CDD\|378280
NC_011653.1\|WP_012579767.1\|754473_755676_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340828
NC_011653.1\|WP_012579777.1\|765691_766627_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_011653.1\|WP_004100287.1\|769549_770854_+\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237046
NC_011653.1\|WP_012579770.1\|758176_759133_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NC_011653.1\|WP_012579778.1\|766613_767906_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|162098

Protein	Function_ID	Function_description	E-value
NC_011653.1\|WP_148203267.1\|760505_761006_-\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	0.00428589
NC_011653.1\|WP_012579772.1\|761308_761971_-\|hypothetical-protein	gnl\|CDD\|200557	cd10931, CE4_u7, Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily. This family corresponds to a group of uncharacterized bacterial proteins with high sequence similarity to the catalytic domain of the six-stranded barrel rhizobial NodB-like proteins, which remove N-linked or O-linked acetyl groups from cell wall polysaccharides and belong to the larger carbohydrate esterase 4 (CE4) superfamily.	1.47357e-45
NC_011653.1\|WP_012579774.1\|762555_763053_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|275030	TIGR04176, hypothetical_protein, EPS-associated transcriptional regulator, MarR family. Members of this family of MarR-family transcriptional regulators are associated with long genomic loci consisting of genes encoding enzymes for the biosynthesis of exopolysaccharides. These genes include glycosyl transferases, sugar modifying enzymes (epimerases, isomerases, methyltransferases, aminotransferases, etc.), and exopolysaccharide polymerases (wzx, wzy). In Leptospira interrogans, borgpeterenii and biflexa, this gene is observed first in unidirectional EPS biosynthesis loci as long as 90 genes. MarR genes (pfam01407) are known to bind to DNA regions with palindromic or pseudopalindromic sequences as homodimers, and to bind small molecules as triggers for conformational changes controlling on/off states.	4.75252e-20
NC_011653.1\|WP_004104694.1\|750936_751842_+\|phosphoribosylformylglycinamidine-cyclo-ligase	gnl\|CDD\|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	8.83663e-104
NC_011653.1\|WP_012579768.1\|755704_757123_-\|oligosaccharide-flippase-family-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	3.01053e-24
NC_011653.1\|WP_012579782.1\|771420_772311_+\|tRNA-dihydrouridine-synthase-family-protein	gnl\|CDD\|239200	cd02801, DUS_like_FMN, Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archaea. Most dihydrouridines are found in the D loop of t-RNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap. 1VHN, a putative flavin oxidoreductase, has high sequence similarity to DUS. The enzymatic mechanism of 1VHN is not known at the present.	6.56243e-95
NC_011653.1\|WP_041427191.1\|759139_760333_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340828	cd03798, GT4_WlbH-like, Bordetella parapertussis WlbH and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.	7.40784e-94
NC_011653.1\|WP_012579783.1\|772384_773362_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213028	cd10973, CE4_DAC_u4_5s, Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel. This family contains many uncharacterized bacterial polysaccharide deacetylases. Although their biological functions remain unknown, all members of the family are predicted to contain a conserved domain with a 5-stranded beta/alpha barrel, which is similar to the catalytic NodB homology domain of rhizobial NodB-like proteins, belonging to the larger carbohydrate esterase 4 (CE4) superfamily.	1.36635e-51
NC_011653.1\|WP_012579769.1\|757157_758180_-\|polysaccharide-pyruvyl-transferase-family-protein	gnl\|CDD\|377253	pfam04230, PS_pyruv_trans, Polysaccharide pyruvyl transferase. Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.	1.10605e-26
NC_011653.1\|WP_012579781.1\|770804_771431_+\|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase	gnl\|CDD\|185680	cd02165, NMNAT, Nicotinamide/nicotinate mononucleotide adenylyltransferase. Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT). NMNAT represents the primary bacterial and eukaryotic adenylyltransferases for nicotinamide-nucleotide and for the deamido form, nicotinate nucleotide. It is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). Nicotinamide-nucleotide adenylyltransferase synthesizes NAD via the salvage pathway, while nicotinate-nucleotide adenylyltransferase synthesizes the immediate precursor of NAD via the de novo pathway. Human NMNAT displays unique dual substrate specificity toward both NMN and NaMN, and can participate in both de novo and salvage pathways of NAD synthesis.	1.20053e-53
NC_011653.1\|WP_012579784.1\|773375_774497_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	3.12664e-161
NC_011653.1\|WP_012579780.1\|768775_769150_-\|DUF2089-domain-containing-protein	gnl\|CDD\|378280	pfam09862, DUF2089, Protein of unknown function (DUF2089). This domain, found in various hypothetical prokaryotic proteins, has no known function. This domain is a zinc-ribbon.	1.37692e-45
NC_011653.1\|WP_012579767.1\|754473_755676_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340828	cd03798, GT4_WlbH-like, Bordetella parapertussis WlbH and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.	3.80529e-97
NC_011653.1\|WP_012579777.1\|765691_766627_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.13659e-83
NC_011653.1\|WP_004100287.1\|769549_770854_+\|GTPase-ObgE	gnl\|CDD\|237046	PRK12297, obgE, GTPase CgtA; Reviewed.	0
NC_011653.1\|WP_012579770.1\|758176_759133_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	2.65833e-18
NC_011653.1\|WP_012579778.1\|766613_767906_-\|MFS-transporter	gnl\|CDD\|162098	TIGR00900, multidrug_transporter, H+ Antiporter protein. [Transport and binding proteins, Cations and iron carrying compounds].	2.21589e-66

>NC_011653.1|WP_012579774.1|762555_763053_-|winged-helix-turn-helix-transcriptional-regulator
MEDNKIKLLEIIYENPGITQREIAKRTGLSLGLVNLLLKKFVRKGLIKLEKLNKKTFKYILTPKGFAEKAKKTIQYIRIYYEKIKQIKVKVEKIVKENGKDKIYAIYGEDEFIINVVREVLKNLKVKYVIYDKTDEITQTQDMIILYWDVEKSNILKDLRSFLVL
>NC_011653.1|WP_012579773.1|761973_762498_-|hypothetical-protein
MKNETINIHPLDVKNYIEKHLNNIFEENIKIDVDEKRNTYIINKIKEVEIYDFWNKEDEELLKDFENYSFKGDCIGTIFFFLSGFWEYTHTYLKDNFGRFPAIESFQYKKNVLEEPVADILIDKLSKELNLTYKNFYTRKNVFITHDVDILQGFKGFRFMRSLVGDVLKRKKYL
>NC_011653.1|WP_012579772.1|761308_761971_-|hypothetical-protein
MDKIIKKLKQIDPFSVFNLIEIHKKYGTTGTFFFLPDNQPKKFGNGYKLHRNIKHLQLLEKEIMAINGSIGIHYDARYLEENRMKNDLDNLKNVFSSIMEAGRAHYLLFDITKSFKILENSGIKIDTTCSYADRVGFRFGTCKPFNPYNFEKNREYGLLEIPLVVMDGTLQSKKYMGLTPKEGLKKIKELINKTIRYKGTLANVTEKVERVKVEKRATPQ
>NC_011653.1|WP_148203267.1|760505_761006_-|transposase
MSKKLKKLFGTLLVIDSTEIKDRYTRLHVLYEAKEKVLIDFKIGEYSETEQAELLLEEVENSILLADRGYWVWRFLERVKDRMRLYVRPRGKEGKKFLKSELNRYIYSKRWEIEWFIERMKQRMKLKGMNEKTLKAQITYMLLGMQLTFLIDTLIHHPKLFRFIDS
>NC_011653.1|WP_041427191.1|759139_760333_-|glycosyltransferase-family-4-protein
MKILILTNLFPKKENPNSGIFITKRLKEHEKLGVDFTAVSLAFRDKGRLLSLLRSLLRKPSEVPLKELEGVSFKPVFVERGLFDVVVQKFWTMKRALENLTDRFAEQVVQNFPKHTVIHAHGMYLPAPAGVVARKVSEIWNVPYVVTLHGSDVNLNMARRDVRDIYLETLENAARCIFVSRALLEKAKSFGYSGQNATVIPNGYDPDVFKPMDKNTVIKELGIYKEDTQYVGFVGNLIPIKRADKLPEIFRKIAKELPNTRFLIVGNGVLRDKILKEMEGLDVIFAGRVPQVEVAKYMNAMNVMVLPSRNEGWPCVVLEAQACGTCVVGSSNGGIPEAIGFDEYVVEEGENFEERFAKRVVDVLKKGYDRDRLIERAKGFTWEEIVKREISILNKVV
>NC_011653.1|WP_012579770.1|758176_759133_-|glycosyltransferase-family-2-protein
MAPIKLLVGIPTLNRADQLKNTLHSILRNTVLPQKIIIVDQSENEKTKHIVNYFREKLNIEYLNVNYKGLTKARNEILSYAKDFDVVTFLDDDVELDKNYFEEIVKAFQEDKNLAGCQGFIENQGGIKGFLFRLAEGMPLTGSPKVTNCFVNTYPFFPPSRPVISEWLSGCNMSYRVDYIEKEKFNENFILYGLGEDLEFSYRLFVSGKRLLMLPSARLKHIPSGLKRLPSRVAVMMRLAYRRYMIAKYRSQVDMLFQEYVEWCRRTFRIHRIVRPQLWKSMMKTIEEVLNELKSHFDMIDKGDLNSVNSLILKEVSM
>NC_011653.1|WP_012579769.1|757157_758180_-|polysaccharide-pyruvyl-transferase-family-protein
MKTLLVAIVGNDNFGDEAMFKAIYRKLLSRGEEIVVATYNVDEAKRRFPNVNFIKIPILSKHQYLLGLMGKNVLSIDISRFDSLYISGGGTLNSLYPLHVFNIYLMVREFRKKRKYVEFRPQSVGPFFGRTKPILEFLIKRIVKFSDKFYVREQASYEYLAKKNLKIELHRDDAWEIPADSSISLPDGKYVGLCIRPWKRQEDLLREYMKELVKEIEKLNYIPLFIPIAYGGSESYIDNAFLKGIVPGIFLDDLIEMDSLTPETIKDIIGRCCFTIGMSYHFNVFSLSQGVPSAAIYLDEYYKIKNLGLYKAFGNPKLVFKIPETPPSELLRTILEISNI
>NC_011653.1|WP_012579768.1|755704_757123_-|oligosaccharide-flippase-family-protein
MKQYRKLAINTFLFAIGNVGSRSISFLLLPLFTRYMVPSDYGKLDVINTTVSLLVPLLSFQIIEATFRFAADVKETGKGKNVFSSAFLFSFLSFLFSVCLYPLLRNIDIFAEFSLYFYSIFFLTVLNGVVKQFVRGLEKIKLYVISDILYSGVFAGSNIILLVVMKLGIRAYLLSNIVALLSSILFIFFSAGLVKYLSPRIDSKTLKEMLSYSIPLIPNGIMWWMVNASDRYFLSYFIGYEATGMYSVASRFPSLITTLYAVFFQAWQLSAIEEFGKEGYGRFFKNVFGMLSSVMFLGSSILFLLIKPFMRVYVGATYFESWKYTVFLFLGAVFNTFASFYGVNYTASKRTAGAFSTSVIAATTKVAVVLSLIKILRIQAASISTFLAYFVMWIVRIFHTRKIVKVELDVKHIVSSSAIVITQAIFLLMIESTVLLYVLQAVLLTILLWSQREYISKAFRFGRSLLGSKAKK
>NC_011653.1|WP_012579767.1|754473_755676_-|glycosyltransferase-family-4-protein
MKPLILTNLFPRKDNPNSGIFITKRLKEYQKLGVDFTAVSLAFRDKGRLLNLLRSLLHKPSEIPLEELEGVSFNPVFVERWLFDVAVQKLWTMKKALENFTDRFAEKISREFPKHNIIHAHGMYLPAPAGVVARKVSEIWNVPYVVTLHGSDVNLNMARRDMRNIYLETLENAARCIFVSRALLEKAKSFGYSGQNAVVIPNGYDPEIFKPIDKDTVRKELGIYKENTHYVGFVGNLIPIKRADKLPEIFGKISKELPNSRFIIVGDGTLRDKILKEMEGLDVVFAGRVPQVKVARYMNAMDVMVLPSRNEGWPCVVLEAQACGTCVIGSSNGGIPEAIGFDEYVVEEGESFEDRFAKRVVEVLKKGYNKNILIERAKSFNWEKTVKREIEVYYQAPWPM
>NC_011653.1|WP_004104694.1|750936_751842_+|phosphoribosylformylglycinamidine-cyclo-ligase
MKYTYKQAGVDVKKGDEFAKIIKENVNIPEWILKEPTGYATVLLFTTPPIAVTADGIGTKILLHIEHGTFKEAAKDLIAMNYNDLICVGAKPIAFLDYIGTHKIGEIEKKFIDALIKELKNCDMYLVAGETAEMPDMYQENHFDVAGFAIGTLIKKFEHSHIKPGDYIMALDSSGFHSNGWSLIRKIISEEKINIKDLPFDILKGTRIYKEIIPYFDKIKAMAHVTGGGITRALRRLLGNLGYEINIEKKEFVDWILKYVEFDEAINTFNMGYGLLYVSETDELPGKVVGRVKESERVIKF
>NC_011653.1|WP_012579776.1|764949_765705_-|hypothetical-protein
MVYLNVFKGTVLRVISELKRYYLNTISFFTIMTMLFYFMVLGITKFGNPANLGESIQALAIGYIVWFTFLGTITDLSWTIINEMSIGLIEQAFISPVGPSTIYLFYQFSNFLIMIPFEFLILIVVFKIAGIPLIIPMSFIITLILLMLQGYGIGLILAGITLRFKRTQALLNIAQFAIIGLLLGDYKGIVKYIVPANGYMKILSNLIEGSSVRFNDWIYMITSSLLYIFVGIILFNYFADVVRKRGEISQY
>NC_011653.1|WP_012579777.1|765691_766627_-|ABC-transporter-ATP-binding-protein
MLQVKNLKKTYVSKGKKVEAVKGITFETEKGEIFAILGPNGAGKTTTIKSILRLIIPDEGEIYINGIDVHKHPSHALKYVSAVLEGNRNIHWKMTVYENLKYFGYIRGLGGKYLKSRISEILEFVELTEKKNELAGKLSRGMQQRLAIGIALLPDTPLILLDEPTLGLDVESSLKVRQMLEKLTKDGKTILLSTHDMQLVEKVANHVLIINKGRVVVSDKKEKLLDAFKKKRFKISFLSNNGYKELEKFGTVVEENGEKILNIQIDNMEQLYEVLEHFKSKNIEIKRLESVMVNFEEVFVNIVRGDENGLS
>NC_011653.1|WP_012579778.1|766613_767906_-|MFS-transporter
MRRTDSTNKLFTKNFLLYIVGRLVSLIGSGIQMIAIPLYILDVTGSGAAMGIFTLLSILPRLSVAPFAGVLGDRFNRKNIMVLTDFIRGFLILFLALLSYTNSLSILILFIIQAFVAMFDGFFGAATTAMIPDIVSEDKLRSANSVLGSVNSFSMIIGPILGGIIYGLFGIFAVFLINGTSFVLSAISEMFIVYKVKFSKKSKLNVSSFFSEFKEGLTFIFKNDGLKYLFTFAMIINFLMSPLFQVVEPYVLRQIVKMSAQQYGFVQTFFTIGMLAGNVFLMSFLKNAKNKTLMISGVSIQSLAIFAFTILIFPNILVKFSIWNFFWLTSIIYFIVGAFNTLVNIPISTNLQLMTPSEIRSRVFSTLEIFSQIMVPLGAVIYGFLIDVVAAHILFLIVNFLALAISIIFFVISPQQVYEPKAGGDFDAAG
>NC_011653.1|WP_012579779.1|767880_768783_-|hypothetical-protein
MNEEIRKVLEALKNGEITTEEAEALIEAIKQREDYKDENFESSDENVETKVGEITVIEEGEVFEGDINIVNGEAVIKGIVNGDCSIVMGKLTFSGEVKGDMNIVGSRVKWNGGVIDGSLNIVASKEEGTPPKVKGGLTRVNNLLLKGLFKVFLKPFLSGFEIKNGNFKKSKKTQKFETLIVEEGKEFKTDDDIVAEEVIVKGKLACGNLKADKIRAIGTISCGNIETEELIVEGTVKTGNVKAENITVYQDGSISSGNVHAENIELNGVISSGNVTCEVIWGNGKLNAGWLNCEENRLNK
>NC_011653.1|WP_012579780.1|768775_769150_-|DUF2089-domain-containing-protein
MLPKCPVCGKPMKVTQLKCVHDNVTVSGMFTVSPLAFLEEEDMNFIILFLRSRGNLKEMERVTGIGYFTLRGRLEKLLDKMGLKPIGDSEVDDQDDVFEKLKKKLISVEDALNIIKRKGGEKNE
>NC_011653.1|WP_004100287.1|769549_770854_+|GTPase-ObgE
MQKADFIDRIVIYVKGGKGGDGSASFRHEKYVPKGGPDGGDGGNGGYVFLKANPNLSTLLSVSEKKKYIAENGENGKGKKMHGRNGKDVVIDVPVGTVVKDFETGEIIADLDKPGMVVCVARGGKGGRGNVHFKSSTMRAPKISERGFEGEERKLVLELKLLADVGLVGYPNVGKSSFISKISNARPKIANYPFTTTIPNLGVVTVNELQFVVADIPGLIKGASKGAGLGNVFLRHVERCSVIAHIVDISGMEGRDPVQDYFDIRNELEHFSSELAQKEEIIIANKIDLISKEELEKRLEKLRKETGKQIFPTSIITGEGIEKIVYKLAEIVKESKKFHTQSEVVNEQIKRPKPLWKELPERFNIEIIKEGNDFIVTGTYVEEWAKRLNLNQKDGYRKFMELLEKNGLEKKLKEAGIKDGDTVWVAQRAFEYKE
>NC_011653.1|WP_012579781.1|770804_771431_+|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase
MAIQFGLPKELLNTKNSLVIFGGSFNPPHNGHIIIAQLVREMFKYADMHIVTSSTPPHKHVDVDFKTRFYLTKKAFEKVKGVEISDIENKLGGISYAINTIEYYEKYYESIFFLVGEDALFSIEKWYRYEDILKKVKMLVYPRYKDKTLYERANNVLKELSNSIYILDLPLIQISSTIVRERVKNKQSIYGFVPESIIELVEEVYGDR
>NC_011653.1|WP_012579782.1|771420_772311_+|tRNA-dihydrouridine-synthase-family-protein
MIGKIGLAPMAGVTNWSFRKLCFGFGAEFAYTEMISAESVIRNLKINEYYFPKPEEKDKVAIQIFGSDPFVMAKAASMLENMGAWIDINAGCPVKKVVKKGAGSALLKDLNRLKNIIMQVKSAVSCKVSVKVRIGFEKDEFEKIYDTVVDAGADMIAVHGRTAKQMYSGKATWNIKNKGYIPLYINGDIHSLSDAKRAMEISKADGVLIARASIGKPWVFNDKPPSLSEIKKIILYHIDLLYSEIGERAAQEFRKFVAGYTKNLPNSRQFRAKVMKINDVETLKKAFEEYLTSISF
>NC_011653.1|WP_012579783.1|772384_773362_+|polysaccharide-deacetylase-family-protein
MKKIVIFLLLFSFISFSNIVIFIYHRFDDERYPTTNTWTSELEMHINLVKKLGYKIWTLKDLEDYVYGNKEEENAVIFTVDDGYVTTYTKAFPVFKKYNVPFSVFLYFGGVGVSKEYLTWDMIREMAEWGVEFGHHSTTHEKFPLLLEKMDLESFKKYFEDDLVKGQKIWQEKMNTSLKYYAYPYGYYNEEMIEILKKYGFRLAFIQLSGPYNKQISPFEIPREALLEDWATESHVRYVLSRQPLILKEKPYFWKDGKLYVKAKLDLSYSNPVVYIREKGIVESTFKDGYLQAGPFEINNDINSLMISARGKDRKEYVRYYLIIK
>NC_011653.1|WP_012579784.1|773375_774497_+|pyridoxal-phosphate-dependent-aminotransferase
MNIIDEIPSSKTLEINALASKLKSEGKDVINLTAGEPDFPTPDVIKQKAHEALDINFTRYTDSKGIVQLRETISKIMQQKGFNFSKDEIIVTNGGKQALFNAVLSTVDKDEEVILISPYWVSYPPMIMLAGASIKVLNTTFEEGFVPNIEELKALISDKTKAIIINSPNNPTGVIYPEEVLRKIAEIANKNKIFVLADDVYDSLVYDGKYTSIANFVDPEYLIYINAFSKSHAMTGWRVGYIATKNKKIYKRIAKIQAHTTSSVNSIAQYAASFALEADTSYMFEEFKKRRDFTIEMAQKIGLEFVKPNGAFYLFFKSPMENDEEFCKKLLEEKLVALVPGSAFMAPGFVRMSFANSLEAINEAFNRIKEFLE

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Crispr_ID: NC_011653_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011653_8

884384-885814

TypeIII

Consensus_repeat	Method
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	PILER-CR
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CRISPRCasFinder
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CRT

21 spacers

cmr1gr7,cmr6gr7,cas10,cmr4gr7,cmr5gr11,cmr3gr5

The CRISPR arrays of NC_011653_8

>merge|NC_011653|8|884384-885814|PILER-CR,CRISPRCasFinder,CRT
ATTTCATTTCCTGCAAGGTAAGGTACAAACACATATGGATATACGCAGATAAAATTAGATTATTTTAATTTCAATTCCTGCAAGGTAAGGTACAAACTCACCCTTCCCTACTCGGATACAGAATGCTGTGTCTCGATTTCAATTCCTGCAAGGTAAGGTACAAACCCAAATGGCAGCGAGATACTGTTTAGAGGTATGGAATTTCAATTCCTGCAAGGTAAGGTACAAACGGAAATTCCAGCAGTGCTCTCCGGAGTCGAAAAGCAAGATTTCAATTCCTGCAAGGTAAGGTACAAACTATTTTGGAGGTGATAAGAAAAAGGCATTAAGCATTTATTTCAATTCCTGCAAGGTAAGGTACAAACTATTACAAGTGTTTGTTTTAGGACTCGCAGCAACAAATTTCAATTCCTGCAAGGTAAGGTACAAACTCAGATATATGGGCATATTAAGTATCGTATAAAGGCATTTCAATTCCTGCAAGGTAAGGTACAAACTAGATTTACTGTTAAAGAAGTAAAATATTTAGACCCATTTCAATTCCTGCAAGGTAAGGTACAAACTAGTTTTAGTATTAGAAAAATTAACTAGAAATAATTCATTTCAATTCCTGCAAGGTAAGGTACAAACCAACCACCTGAAAATTTAGGACGTGGGTCTGTAGTAATTTCAATTCCTGCAAGGTAAGGTACAAACTTTATTATGATGCTACAAAAAAGGTTTTTATATCCCAATTTCAATTCCTGCAAGGTAAGGTACAAACTGATTGGGAAGAATGGTTAGGTACATTAGAAAACGAATTTCAATTCCTGCAAGGTAAGGTACAAACTTGGAACGATGTCGCAATTATAAATGTTCCTGTAAATTTCAATTCCTGCAAGGTAAGGTACAAACATTTCTCAATATTATTAGCGATTTTCCCGAAGATTAACATTTCAATTCCTGCAAGGTAAGGTACAAACAATTAATTCTTGTAGGTTGCCTGTTTCAATTTCTAATTTCAATTCCTGCAAGGTAAGGTACAAACTAATCTCTGCCACACTTCACACCTCTTCAAATAACGGATTTCAATTCCTGCAAGGTAAGGTACAAACAGGAGATTTTTTTGGCATGCTAAAACAGTTTTATCTAAATTTCAATTCCTGCAAGGTAAGGTACAAACCACCACCAAATTTAACTTTCTTGTTCAAGTTTCACAAATTTCAATTCCTGCAAGGTAAGGTACAAACCATTAGCTTAACGTATGCTGTAAAAAAACATTGTATAAATTTCAATTCCTGCAAGGTAAGGTACAAACTAATAATATTAAATACAATTAGATATAGAAACAAAAATTTCAATTCCTGCAAGGTAAGGTACAAACGAATTCGATAACATAACTATAACTGCTAATAAGGTAGTATTTCAATTCCTGCAAGGTAAGGTACAAAC

>NC_011653|8|12|884384-885814|PILER-CR
ATTTCATTTCCTGCAAGGTAAGGTACAAAC	ACATATGGATATACGCAGATAAAATTAGATTATTTTA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TCACCCTTCCCTACTCGGATACAGAATGCTGTGTCTCG
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CCAAATGGCAGCGAGATACTGTTTAGAGGTATGGA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	GGAAATTCCAGCAGTGCTCTCCGGAGTCGAAAAGCAAG
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TATTTTGGAGGTGATAAGAAAAAGGCATTAAGCATTT
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TATTACAAGTGTTTGTTTTAGGACTCGCAGCAACAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TCAGATATATGGGCATATTAAGTATCGTATAAAGGC
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TAGATTTACTGTTAAAGAAGTAAAATATTTAGACCC
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TAGTTTTAGTATTAGAAAAATTAACTAGAAATAATTC
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CAACCACCTGAAAATTTAGGACGTGGGTCTGTAGTA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TTTATTATGATGCTACAAAAAAGGTTTTTATATCCCA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TGATTGGGAAGAATGGTTAGGTACATTAGAAAACGA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TTGGAACGATGTCGCAATTATAAATGTTCCTGTAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	ATTTCTCAATATTATTAGCGATTTTCCCGAAGATTAAC
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	AATTAATTCTTGTAGGTTGCCTGTTTCAATTTCTA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TAATCTCTGCCACACTTCACACCTCTTCAAATAACGG
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	AGGAGATTTTTTTGGCATGCTAAAACAGTTTTATCTAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CACCACCAAATTTAACTTTCTTGTTCAAGTTTCACAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CATTAGCTTAACGTATGCTGTAAAAAAACATTGTATAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TAATAATATTAAATACAATTAGATATAGAAACAAAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	GAATTCGATAACATAACTATAACTGCTAATAAGGTAGT
ATTTCAATTCCTGCAAGGTAAGGTACAAAC

>NC_011653|8|8|884384-885814|CRISPRCasFinder
ATTTCATTTCCTGCAAGGTAAGGTACAAAC	ACATATGGATATACGCAGATAAAATTAGATTATTTTA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TCACCCTTCCCTACTCGGATACAGAATGCTGTGTCTCG
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CCAAATGGCAGCGAGATACTGTTTAGAGGTATGGA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	GGAAATTCCAGCAGTGCTCTCCGGAGTCGAAAAGCAAG
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TATTTTGGAGGTGATAAGAAAAAGGCATTAAGCATTT
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TATTACAAGTGTTTGTTTTAGGACTCGCAGCAACAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TCAGATATATGGGCATATTAAGTATCGTATAAAGGC
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TAGATTTACTGTTAAAGAAGTAAAATATTTAGACCC
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TAGTTTTAGTATTAGAAAAATTAACTAGAAATAATTC
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CAACCACCTGAAAATTTAGGACGTGGGTCTGTAGTA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TTTATTATGATGCTACAAAAAAGGTTTTTATATCCCA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TGATTGGGAAGAATGGTTAGGTACATTAGAAAACGA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TTGGAACGATGTCGCAATTATAAATGTTCCTGTAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	ATTTCTCAATATTATTAGCGATTTTCCCGAAGATTAAC
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	AATTAATTCTTGTAGGTTGCCTGTTTCAATTTCTA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TAATCTCTGCCACACTTCACACCTCTTCAAATAACGG
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	AGGAGATTTTTTTGGCATGCTAAAACAGTTTTATCTAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CACCACCAAATTTAACTTTCTTGTTCAAGTTTCACAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CATTAGCTTAACGTATGCTGTAAAAAAACATTGTATAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TAATAATATTAAATACAATTAGATATAGAAACAAAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	GAATTCGATAACATAACTATAACTGCTAATAAGGTAGT
ATTTCAATTCCTGCAAGGTAAGGTACAAAC

>NC_011653|8|8|884384-885814|CRT
ATTTCATTTCCTGCAAGGTAAGGTACAAAC	ACATATGGATATACGCAGATAAAATTAGATTATTTTA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TCACCCTTCCCTACTCGGATACAGAATGCTGTGTCTCG
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CCAAATGGCAGCGAGATACTGTTTAGAGGTATGGA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	GGAAATTCCAGCAGTGCTCTCCGGAGTCGAAAAGCAAG
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TATTTTGGAGGTGATAAGAAAAAGGCATTAAGCATTT
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TATTACAAGTGTTTGTTTTAGGACTCGCAGCAACAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TCAGATATATGGGCATATTAAGTATCGTATAAAGGC
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TAGATTTACTGTTAAAGAAGTAAAATATTTAGACCC
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TAGTTTTAGTATTAGAAAAATTAACTAGAAATAATTC
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CAACCACCTGAAAATTTAGGACGTGGGTCTGTAGTA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TTTATTATGATGCTACAAAAAAGGTTTTTATATCCCA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TGATTGGGAAGAATGGTTAGGTACATTAGAAAACGA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TTGGAACGATGTCGCAATTATAAATGTTCCTGTAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	ATTTCTCAATATTATTAGCGATTTTCCCGAAGATTAAC
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	AATTAATTCTTGTAGGTTGCCTGTTTCAATTTCTA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TAATCTCTGCCACACTTCACACCTCTTCAAATAACGG
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	AGGAGATTTTTTTGGCATGCTAAAACAGTTTTATCTAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CACCACCAAATTTAACTTTCTTGTTCAAGTTTCACAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	CATTAGCTTAACGTATGCTGTAAAAAAACATTGTATAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	TAATAATATTAAATACAATTAGATATAGAAACAAAA
ATTTCAATTCCTGCAAGGTAAGGTACAAAC	GAATTCGATAACATAACTATAACTGCTAATAAGGTAGT
ATTTCAATTCCTGCAAGGTAAGGTACAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011653.1\|WP_004104366.1\|893368_894448_-\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	unknown	unknown	gnl\|CDD\|99740
NC_011653.1\|WP_148203268.1\|878041_879130_-\|hypothetical-protein	cmr4gr7	COG1336_cmr4gr7_CAS-III-C	gnl\|CDD\|224255
NC_011653.1\|WP_012579845.1\|889147_890239_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340825
NC_011653.1\|WP_049750534.1\|875865_876123_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|377306
NC_011653.1\|WP_004104368.1\|891716_892787_-\|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|224013
NC_011653.1\|WP_012579835.1\|877677_878055_-\|hypothetical-protein	cmr5gr11	mkCas0117_cmr5gr11_CAS-III-C	unknown
NC_011653.1\|WP_012579839.1\|883324_884293_-\|cmr-CRISPR-associated-ramp-protein,-Cmr1-family	cmr1gr7	mkCas0175_cmr1gr7_CAS-III-C	gnl\|CDD\|377130
NC_011653.1\|WP_012580547.1\|874075_875335_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_011653.1\|WP_004104361.1\|894444_895317_-\|glucose-1-phosphate-thymidylyltransferase-RfbA	unknown	unknown	gnl\|CDD\|130274
NC_011653.1\|WP_041427312.1\|890256_891654_-\|oligosaccharide-flippase-family-protein	unknown	unknown	gnl\|CDD\|240533
NC_011653.1\|WP_004104367.1\|892791_893364_-\|acyltransferase	unknown	unknown	gnl\|CDD\|100053
NC_011653.1\|WP_012579844.1\|888160_889135_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133016
NC_011653.1\|WP_012579832.1\|872467_873718_-\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_081429700.1\|876848_877691_-\|hypothetical-protein	cmr3gr5	mkCas0067_cmr3gr5_CAS-III-C	unknown
NC_011653.1\|WP_012579842.1\|886438_887140_-\|NERD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377990
NC_011653.1\|WP_004104359.1\|895316_896393_-\|TDP-N-acetylfucosamine:lipid-II-N-acetylfucosaminyltransferase	unknown	unknown	gnl\|CDD\|235070
NC_011653.1\|WP_012579838.1\|882345_883347_-\|CRISPR-associated-ramp-protein	cmr6gr7	mkCas0142_cmr6gr7_CAS-III-C	gnl\|CDD\|213662
NC_011653.1\|WP_049750533.1\|875413_875674_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225420
NC_011653.1\|WP_012579837.1\|879156_882339_-\|CRISPR-associated-protein-Csx11	cas10	cd09701_cas10_CAS-III-C	gnl\|CDD\|187832
NC_011653.1\|WP_012579843.1\|887402_888155_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|100048

Protein	Function_ID	Function_description	E-value
NC_011653.1\|WP_148203268.1\|878041_879130_-\|hypothetical-protein	gnl\|CDD\|224255	COG1336, COG1336, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.02208e-24
NC_011653.1\|WP_012579845.1\|889147_890239_-\|glycosyltransferase	gnl\|CDD\|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	2.2747e-24
NC_011653.1\|WP_049750534.1\|875865_876123_-\|ATP-binding-protein	gnl\|CDD\|377306	pfam04326, AlbA_2, Putative DNA-binding domain. This family belongs to the AlbA clan of DNA-binding domains.	1.84587e-12
NC_011653.1\|WP_004104368.1\|891716_892787_-\|dTDP-glucose-4,6-dehydratase	gnl\|CDD\|224013	COG1088, RfbB, dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane].	0
NC_011653.1\|WP_012579839.1\|883324_884293_-\|cmr-CRISPR-associated-ramp-protein,-Cmr1-family	gnl\|CDD\|377130	pfam03787, RAMPs, RAMP superfamily. The molecular function of these proteins is not yet known. However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	4.8332e-06
NC_011653.1\|WP_012580547.1\|874075_875335_-\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	3.27966e-31
NC_011653.1\|WP_004104361.1\|894444_895317_-\|glucose-1-phosphate-thymidylyltransferase-RfbA	gnl\|CDD\|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	9.51194e-168
NC_011653.1\|WP_041427312.1\|890256_891654_-\|oligosaccharide-flippase-family-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.12159e-27
NC_011653.1\|WP_004104367.1\|892791_893364_-\|acyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	1.06983e-29
NC_011653.1\|WP_012579844.1\|888160_889135_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133016	cd02525, Succinoglycan_BP_ExoA, ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.	1.53956e-105
NC_011653.1\|WP_012579838.1\|882345_883347_-\|CRISPR-associated-ramp-protein	gnl\|CDD\|213662	TIGR01898, repair_system, CRISPR type III-B/RAMP module RAMP protein Cmr6. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1791 of Thermotoga maritima, is designated Cmr6 [sic], for CRISPR/Cas Ramp Module protein 6. This family is both closely related to and frequently encoded next to the TM1792 family of Cas proteins described by TIGR01867. The two proteins are fused in an example from Methanopyrus kandleri.	0.00180279
NC_011653.1\|WP_004104366.1\|893368_894448_-\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	gnl\|CDD\|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	1.9693e-118
NC_011653.1\|WP_012579842.1\|886438_887140_-\|NERD-domain-containing-protein	gnl\|CDD\|377990	pfam08378, NERD, Nuclease-related domain. The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.	3.63199e-19
NC_011653.1\|WP_004104359.1\|895316_896393_-\|TDP-N-acetylfucosamine:lipid-II-N-acetylfucosaminyltransferase	gnl\|CDD\|235070	PRK02797, PRK02797, TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase.	9.16625e-121
NC_011653.1\|WP_012579837.1\|879156_882339_-\|CRISPR-associated-protein-Csx11	gnl\|CDD\|187832	cd09701, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, inactivated palm domain and Zn-ribbon; signature gene for type III.	1.02136e-95
NC_011653.1\|WP_049750533.1\|875413_875674_-\|hypothetical-protein	gnl\|CDD\|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	1.58634e-05
NC_011653.1\|WP_012579843.1\|887402_888155_-\|N-acetyltransferase	gnl\|CDD\|100048	cd03358, LbH_WxcM_N_like, WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization and transacetylation reactions of keto-hexoses. It contains an N-terminal LbH domain responsible for the transacetylation function and a C-terminal isomerase domain. The LbH domain contains imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), typical of enzymes with acyltransferase activity.	7.39926e-52

>NC_011653.1|WP_012579839.1|883324_884293_-|cmr-CRISPR-associated-ramp-protein,-Cmr1-family
MIKELKVKFKTLSPLWTGNYRGITNEIRPSSLIGSLRFWLDIICYFSGLQINDLGSFDPEKFQNFILKEGTDFESLNKIFSEFRLSLSSKIFGCNKWEGWIRIKEIKPVGKYCFGNYLNLDNSYRKPYFWGTFEVTFEVEEKIINPIFYPLLYFMELYGFWGGKWSLGYGRLQVVNMEIDGKILNSEQWRKNEFKFKLFGNENIFFLENSEKSDIIKVEEGEEKDFEILLSKNKKINVLFLKNIDGKGYSELIKSLKEIKFNKQNEHKSKYLFGSKSKGSKIFPLITYQIQKDKYEGGLKVGFISIVNFLKGSEKNEKANKI
>NC_011653.1|WP_012579838.1|882345_883347_-|CRISPR-associated-ramp-protein
MKKPIKFETYINIKNKMIEYNGLIISNNTLNIIEKAKKISGILKENELENYISRLIPYSFIFWAEIELINPYFSKDDEDYNLTKKNLCIKDKAFKIPMIRGSAWKGVFANAFKILINESLFSSNTEEKAIDYIQSFARIFGTGSMEFRKFTKMLSELLEDKLKEKDMHEIIKYLIFELGLRLKKDDIDNLRKKENFKDWVRNNIWKKYGETSEKNLPFFLKPHKGRAIFYPTFFSRLSTEVINPHSKEERKGKGPIFFEVVSKYSRGIVQIVYIPFDGIRLEREVLKDQVEKDVKFIELSFKKVSDIGIGAKSKLGWGRFTIKSKKLKFAAMR
>NC_011653.1|WP_012579837.1|879156_882339_-|CRISPR-associated-protein-Csx11
MDSCVIEKISNHKEDILKAEVGALLFNIGKTHAGINNWIKYFPNAKQKIRKYEYYYNKLFKDEIDEVDQVFEEFFNQKIRLPNLLEVEWIKFFDRDFDRDFNEFFFRGCENLNSGIDKGFPKEILKRLYISNAFGAFIENVEEKNFDEKRKQFLKNLYEYLKDNNDFENSDWQQVRNWILSEIKNWYTHLLSDNRFPVNDVTLYDQVYMVASLFKATLSGLYLYKEKVNEYINNPSNIKWCILGIQYDKLGLSEKALKISNIQWYRKNVKEVDRKVKQLLEEECPIGNEVYRDETGIYFVVSELLKGKKEGEFYKLRDDLKKLEEKIIEKFREVFNDEIYPAIFLSESSRGLMNLGRLVEKAPENFLKAKVLYKNNENNSNNSLKIGICQICGVRTVEKKGKLNELICDTCLKRQEERMKNWLDNRNGETIWLDELQDKNGRIALITLKFEANEWINGDLVNTFLTNDINALYNKSKDYHILFKEMCNTLKAVKDLSKKSKLYGLKAFTSKDLSKLKDEELFEYLNEIERIIEPISENTITSKFGKLEKSGEKYLIIKNNNSDLIKNLLNNNKFKNFLEIYDFKIFKELAMEVYKKSFNDFIKQIFFGNIVDTNWEIFVKSTRLKNKIDFNKEEIHWEFLDDRDIEFLSTLLLQFLLRKNPSPARLRRIWETTKNFFENLEKEKLKLLNFPKSRCQRLYWERVNIPDGEYADGDILFWAKNNTVYLISSIEKVANKDSFEIKKIDDDSHIIKKLYIEDANEEEYEPFFTILSPTPVSWQFIIPAEYVPNLIESVKDEYYRYFKWVYGKFPLHIGIVVQNYKKPLYVGLKALRRIRRDCQKWEDLKKKIAVSDFKSRQKHAGCCCCSFDENNSEKYYSLFERADAVQRGYAFYLYPSDDGKVWIDTTQNSNDKDIFWFYPNTFDFEFLDSNARRNEIYYEKGRRKISIKKNRPYDIEDWQYFSKFNEFFKDNVNSESKLQKLVTLIYSKLADWNDLYSLKIFMLSSFVNILEIKGTKKDEFAKVFGVENWESLEKMPEDKFEEKLYMFIDMFEFWYRILKV
>NC_011653.1|WP_148203268.1|878041_879130_-|hypothetical-protein
MLVTNKRIFAQAMDPIYIGTGGYNIGRVDNTIVRDPITNIPKIPGSSLAGTWRYYSALELVSRVKDYQPSFKDIKSINGENFSSKLKNAKWKNDFPFGEHDWESYPGNKVARIKCAGQDDLPNKSIDDIEEETGHCGHCIVCKSFGFSKKDISMQGLVFFSDLKILLYPVFTMQGTKWITSEGLLKEAGVLDSTKENNVNELVYYVITNEDDKVGHINLGWLYFPYKKVETNIDLSLLEGAISLSDIVIVPENLISQIINSNLEVRTSVSINPITGAAKEGALFTSEAIPRGTIFYGEIRFFDRSKLIEDLPLKEFVFKMLEDSKKYYETLGVGGMTTRGFGRMKVLTKLNKSNGGDSNEKS
>NC_011653.1|WP_012579835.1|877677_878055_-|hypothetical-protein
MKNLEASINKTSFEIAEYLENENNINKMLGVLSNYGVYALWIFSKKILKDEKNKEFWNKIFNGLEELIISFGILDKNDKGLSEKSFEKLSEDLEKVLFFKDVLEKVLVYSRYHVKAMDKGKNGGE
>NC_011653.1|WP_081429700.1|876848_877691_-|hypothetical-protein
MVVNNVESSSKGIWYKLVFKQVQPIHIGYKRYGVINETRIFIPGWTMWGALTNIYGLYTGSYEDIDEVFEEISCFWPSFDKGGNDVLFPSLRYGKLHLGNFSEEKFRTMFVDTIISTAISPVLRSAKDESLHEIDVILPRPREEFVRELDANISLYWVGILNIKDQKLLSFLKSGLEIFVGGDIKYGLGLLKLEYINECEEISKFKKNNFLEINEEEFNSENLDKMGELIVDIENTIDGALLKIKEEKLLFLWDTNNKEKIIDLENYKLEKGKLLKNFKD
>NC_011653.1|WP_049750534.1|875865_876123_-|ATP-binding-protein
MESFLKTVVAFANGSGGKIIFGIKDKTREIVGILEDEIFSMMDSITNMIHDKCFPTIIPEIYIENVYNKKCSWLKFTLDHKNHII
>NC_011653.1|WP_049750533.1|875413_875674_-|hypothetical-protein
MTKSDLYNLKILKNIRQRDYLTVGGALLSGKDNLFGYAKISYARFKGISLSTKEFIDQKEYSGPLYKKVESAFNFAIEHIEKREFL
>NC_011653.1|WP_012580547.1|874075_875335_-|IS110-family-transposase
MKQKSINKKISRITQDTLIVGIDVAKRTHWIRMMDFRGIDLIKPFKINNTMDGIKMLEEKIKSVKEENKLNKVVLGMEPSGHYWKVLAWQMKISKEIDYLVGVNPYHVKKSKEFDDNSPGKSDRKDAGVIARLIRDGRYFDIYLPEDIYGELRVITTTREQLVNKRKNAKNMVISVMDEYFPEYEKIYKNIFSEGSIKLLKTHPFPKEIIEVGIEEIEKVLKKSTNGKDWKSRAQKIYESAKKSIGVREGQKSAKIKLRMLLEEIEFLTSQIEELEKEMEELVEETEEGEYIKSVPGIGPIMTAVILGEIGDINRFKSWKEIRKLAGLNLYEISSGEHKGKTRITKRGRPLLRKIIYLMAQTTLKHNHEIRKKYEQLRRREKNPLKVVQALIAIGLKMIRIVFKLAKSKIKYEPEKVYV
>NC_011653.1|WP_012579832.1|872467_873718_-|hypothetical-protein
MKKLILIFLGIGLTLFSNVPIIKINITAPSYIEIINATIYDSIIESGKFKLYLQDELEKLYKELRLQDLLSNKNLILKESKQPIINFDVVIKNLQIKEEKIKKDYIVNNESGDYIRVGEKYIKVQKGIYYSYDVNTSRYIPSKDGYYIKGYDGKFYTFNDFYTKFSHEKIVYKVSGKVYYNLFGYANDSFSFSKEIKKRWYKWDETILKPMKKENSQIEILKYIASVIKSNILENIKNAYKLEGLIYDLKKDRVILNIGKKDGVLPGTVFTIAENKGQIVIKNVENNYSEAEFYYLKKHSKIEIGDQVVEDSKKIFIPISLGIYYTSNGLKISLGLRQRDVYNDKKAFLVVDYLTNTQNYIFTLGYNIFDFYELKTYLSLSSNYSIGGMIKYDLFDLMFNYSLQNKTFNFGGGFSW
>NC_011653.1|WP_012579842.1|886438_887140_-|NERD-domain-containing-protein
MFARILRQNSEIKEKFYNLISEKENNQKRIFLEKFDKNLFLKVLKPFANIWYTYELKSKKKKGDDGETDVSFFLWICLSRKAIIVNDVVLEVAKGEFIQIDHLIFHQKGIFVIETKNWNGALICDKDIWRLKVGNTWQEVSSPSKQNQRHVRLLLKWFENNLPERLYEKIKDYVFPVVVFPRSNWIKVKNCSMPVFKGKLSLLLYIISQKNKIFEEHELTYVAAKMVSAKPFN
>NC_011653.1|WP_012579843.1|887402_888155_-|N-acetyltransferase
MYISETAKVGKNVKFGHNVVIEDNVVIGDEVVIGHNVVVKEGTVIGRGCVIADNTVLGKKPFKASASATTEEKTLPPLVLGEYVTIGANCVIYRGAVLKDFVFVGDLASIREDVEIGEYTIIGRGVTVENKTRIGKYVKIETEAYITAISTVEDYCFVAPEVTFTNDNFLGRTEERKKYFKGPTLRKGARIGANATILPGIEIGEDALIAAGAVVTKNVPPKKIFAGVPAKEFRDVPEEQLLKNQKYYKE
>NC_011653.1|WP_012579844.1|888160_889135_-|glycosyltransferase-family-2-protein
MKKVTIVIPTRNEEKYIEKCINSILENDYPEKEIIVVDGMSSDRTREILKEYKDIKIIDNPEKITPIALNIGIENATGDYIMIAGAHSTYSKNYISECIKRLDEGKCEIAGGKVITKPGNDTKKAIAISRVLSHPFGIGGARYRINPQKEMYVDTVAYGIYKREVFEKVGTFNPNLVRNQDIEMNLRIKNAGMRILLVPNAESYYYARDNFKSLFKNNFQNGLWVILSTKYAKRAFSLRHLVPLFFVLFLLSILFVYKISFLKSVYFSILALYLFLNIFFSLKIALKEKSLKVFFYSFISFLILHISYGLGSFVGIFKRLFSKG
>NC_011653.1|WP_012579845.1|889147_890239_-|glycosyltransferase
MKIFIIGYMHPKYDKRVFRTVKALSKDNEVIYQYWTDKEEIESKEGNIFYKPIKYEKNVKANPILKLMRRRKLDKKIVEMIKNYDYDIVYFHHFLASRPLAPFKVARRRDKVVIYDIHEYHPENFLNILKGFAKVLKEKIMWKIFERQLKLSDKLIFVSKETQKDVYKRLGIDKPYLIAPNYASISVESREKKKEISFVGKVTRNLANEKKIIKKLIERGFKFKIIGMDSDVFKDIPHEYTTFLPYEDMMEQLSKSAFSLISYNTIMDESYKNDIFALPNKYYDSIAAETPVIVKNTFVSMAKEVEKYGIGVVIDPNNVDKSVEKILKAYENYENLLENIKKYKDRFVWNEKKEKEFISFVLD
>NC_011653.1|WP_041427312.1|890256_891654_-|oligosaccharide-flippase-family-protein
MKNYIKSFFSFSIGTWIRAIIVFFSTPIISYLILPEEFGRASMFTLAYNIALLVTLLGLDQSLVRYYYEEEDKNNVFWSCLFPSVILGFFVSIFFIVFEKSLSIFLYGDYYKGIGYLFAFSLLSGIFQRFNQLSIRMQKRGFLFSFINVILALGNFGGTVVFALTVSRSFYAIIFGQIIGNIFALLVGFFVDKQSRSFSKIDFEKLLEFLKYGIPFIPSSILYWLFSSIDRISLRQFSTFTEIGLYSAAFKIVSIMQLIQVGFTTFWVPLAYEKYNSKAISDNFFEKANSLISAILFIFGLLLLAFKDLIIFLLFAKSYREASYIAPFLILYPIMYMLSETTVLGINFSKKTYWHIVITGVSAFVNFVGNNLLVPFLGAKGAAISTGLSYVVFFTLRTIIAQKYYTMHIKIKRIYMSVILIVIVASLGTFFKASYIYYIFCILVLLIYLLLYKDVISYVKDQMKK
>NC_011653.1|WP_004104368.1|891716_892787_-|dTDP-glucose-4,6-dehydratase
MKLLVTGCCGFIGSNFVYYYLEKHKEAQIIGLDKLTYAGNLDNLSKLSDDQKKRFEFVRGDINNGELIEYLIEKYDIDVIVNFAAESHVDRSIYNPREFLETNVLGVQTLLDVVRKKWNKNGKWIEGKKFIQISTDEVYGTLGPSGKFTEKTPISPRSPYSASKASADLLVLAYHETYGMPVNITRCSNNYGPYQFPEKLIPLMILNALEHKNLPIYGDGRQIRDWIHVLDHCRAIDLVIEKGKVGEVYNVGADNEWENIKIVRKIIEILREFTKDEEINENLIKHVKDRPGHDRRYAIDSTKIQHELGWKPEITFEKGLRDTIKWYLDNKEWIEKIRSGEYRDWYEKHYVSEKKI
>NC_011653.1|WP_004104367.1|892791_893364_-|acyltransferase
MKTSFYTPEELKELGFKSIGKNVLISRKASIYKPELIEIGDNVRIDDFCILSGKIKLGSFIHIAAGCYLFAGEAGIIMEDFSGLSSRVSVYAITDDYSGEFLTNPMVPEKYRNIISEPVIIKKHGLIGTGATILPGVTIGEGAAVGSMALVNKDIPEWTIAVGIPAKPVKERKRDLLELEKRLYEELKLR
>NC_011653.1|WP_004104366.1|893368_894448_-|DegT/DnrJ/EryC1/StrS-family-aminotransferase
MINVTRSIMPDFEKYTQMIEKLWETRWLTNNGEYLVKLEKALEERFNTKCAVVSNGTLALLIAIELFDFPKDSEIITTPFTFVATSSSIIWQKYKPVFVDINPETFNIDPNEIEKKITENTRAILAVHVFGNPCDIEKIEEIAKKHRLKIIYDAAHCFDVYYKGESIYKFGDVSIASFHATKVFHTIEGGAIFSDNDELIRKAKRLRNFGFNEEIEIEDKGINAKMNEFQAAMGLLNLEIVGKEIKKRKKIYESYKEKLKGLVKFQKLSSNITKYNYIYMPVLFENQEQREKAYKKLKEEGYNTRKYFFPSLDTVFNQENQCKTSQEISKRILHLPLYGDLEEKHVEKICTTIEKVVRG
>NC_011653.1|WP_004104361.1|894444_895317_-|glucose-1-phosphate-thymidylyltransferase-RfbA
MKGIILSGGKATRLYPATISVSKQLLPVYDKPMIYYPLSILLFAGIREILIITNPEFLPLYQKLLDDGSQLGIKITYKEQLKPRGIADAFLVGEEFIGDSNVALILGDNLFFGQSFGQAVQKAAQFKEGAVVFAYPVRNPKDFGVVEFDKNGKAISLEEKPEKPKSNWAVPGLYFYDNKVVEIAKNLKPSARGELEITDVNKEYLKKGELKVIPLGRGVAWLDTGTPEGLLEASNFVATIQKRQGFYIACIEEVAYRMGYITREQLYELGKKQEKTDYGKYILELAGEIK
>NC_011653.1|WP_004104359.1|895316_896393_-|TDP-N-acetylfucosamine:lipid-II-N-acetylfucosaminyltransferase
MYLHILNDNKYSDKFIEFINQNFSISDHHFVTFSKRPKYLDRGKVEIVDIYKLSQIRWLYKKISNADKIFLHSLFRGGKSLMLFLFNRKNLYKTYWVVWGGDLYNYWLKDSHSVREKVLEKLKRKVIKKIYGIIALVQEDYLFAKEKYKTKAKYYYAFYLNPVDFKMLDTFSDQKNKEEKTILIGNSAAPTNNHFEILSSLSKYRLNNFKIICPLSYGSSQEYIKKVCEYGVKLFGDNFIALTEFLSPEEYAKILANVDVAIFAHRRQQALGNILALLYLGKKVYIRSDISSWAFFNRFGIKVFDTKNILDGSEKDIFTFEEKIAIKNREIVLNEFSEERCVQLWKNVFESKLNGRDM

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Crispr_ID: NC_011653_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011653_9

1182891-1184387

Orphan

Consensus_repeat	Method
GTTTCAATTCCTACAAGGTAAGGTACAAACN	CRT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	PILER-CR
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CRISPRCasFinder

22 spacers

The CRISPR arrays of NC_011653_9

>merge|NC_011653|9|1182891-1184387|CRT,PILER-CR,CRISPRCasFinder
TATTAAATTCCTACAAGGAAGGTATAAACATTTTTAACACGTTTTTTGTATTTCTTTTGCTATATAAGTTTCAATTCCTACAAGGTAAGGTACAAACTATGTAGCTGCTTTATCCGTGCTTATACCAACTTTTGGTTTCAATTCCTACAAGGTAAGGTACAAACTTAATCCCCTGGATCAAGAACACTTTCTTTATATTCTGTTTCAATTCCTACAAGGTAAGGTACAAACGCAATTTTACTACTTATTCTAATTTTAAAAACAAAGGTTTCAATTCCTACAAGGTAAGGTACAAACCGAATAGACTAAATGAATTATTGAAGCAAAACAACTTGTTTCAATTCCTACAAGGTAAGGTACAAACAAATCCGCTCTCACTAACTATTAATGCAACAAAAATTGTTTCAATTCCTACAAGGTAAGGTACAAACTAAAAATCGAAACAGATAGATGTTCCTATTCATTTATGTTTCAATTCCTACAAGGTAAGGTACAAACAAGAAGTTGTGCGGTCATGTATTCTATTGTTCTTTCAATGTTTCAATTCCTACAAGGTAAGGTACAAACGCAAATCTGAGACAACTTCAGACCTGATAGCAGAAATGTTTCAATTCCTACAAGGTAAGGTACAAACAAGAAATTGGAAGAACTAAAAGGAGGTATAAAACAGGTTTCAATTCCTACAAGGTAAGGTACAAACCGAACTTGAAAACAAAGTTTCAATAGAGCAAAAAGGTTTCAATTCCTACAAGGTAAGGTACAAACTATAACCCATTAGAAACAACAGGCGATGAAAAAGAAAGTTTCAATTCCTACAAGGTAAGGTACAAACTAGAAACAGATGGTACAATTAAACCAGCAGAATATAGTTTCAATTCCTACAAGGTAAGGTACAAACCCGGATACACTTTAAGTTTCTCTGGCAAATATAAAGTGTTTCAATTCCTACAAGGTAAGGTACAAACAAGGAAGTGTTGAAGTGGCAATTGAAGGAGTTTGCTGGTTTCAATTCCTACAAGGTAAGGTACAAACTGACGAAGCGCCTGAAGCATACAAGGACATCATGTAGTTTCAATTCCTACAAGGTAAGGTACAAACAATGGTTCTTCCGTAAAAGATAAATAGCCAACAAAAGTTTCAATTCCTACAAGGTAAGGTACAAACATTTATGGAAACGGTTCCATATGGTATAGTTTGAGGTTTCAATTCCTACAAGGTAAGGTACAAACAAGGAGGTAACATTATGGCACAGAACGTTGTGAATGCGTTTCAATTCCTACAAGGTAAGGTACAAACTAGTTCTTTCACTCAACTCCGCCCCGCGATATTGCTAGTTTCAATTCCTACAAGGTAAGGTACAAACAAGTAACCCTTCAAGACACTTCCATCGTATATCCATGGTTTCAATTCCTACAAGGTAAGGTACAAACCACCACCAGAAGTTATTAATTTTACCCATGCATCAGCGTTTCAATTCCTACAAGGTAAGGTACAAAC

>NC_011653|9|9|1182891-1184387|CRT
TATTAAATTCCTACAAGGAAGGTATAAACA	TTTTTAACACGTTTTTTGTATTTCTTTTGCTATATAA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TATGTAGCTGCTTTATCCGTGCTTATACCAACTTTTG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TTAATCCCCTGGATCAAGAACACTTTCTTTATATTCT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	GCAATTTTACTACTTATTCTAATTTTAAAAACAAAG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CGAATAGACTAAATGAATTATTGAAGCAAAACAACTT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAATCCGCTCTCACTAACTATTAATGCAACAAAAATT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TAAAAATCGAAACAGATAGATGTTCCTATTCATTTAT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGAAGTTGTGCGGTCATGTATTCTATTGTTCTTTCAAT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	GCAAATCTGAGACAACTTCAGACCTGATAGCAGAAAT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGAAATTGGAAGAACTAAAAGGAGGTATAAAACAG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CGAACTTGAAAACAAAGTTTCAATAGAGCAAAAAG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TATAACCCATTAGAAACAACAGGCGATGAAAAAGAAA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TAGAAACAGATGGTACAATTAAACCAGCAGAATATA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CCGGATACACTTTAAGTTTCTCTGGCAAATATAAAGT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGGAAGTGTTGAAGTGGCAATTGAAGGAGTTTGCTG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TGACGAAGCGCCTGAAGCATACAAGGACATCATGTA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AATGGTTCTTCCGTAAAAGATAAATAGCCAACAAAA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	ATTTATGGAAACGGTTCCATATGGTATAGTTTGAG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGGAGGTAACATTATGGCACAGAACGTTGTGAATGC
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TAGTTCTTTCACTCAACTCCGCCCCGCGATATTGCTA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGTAACCCTTCAAGACACTTCCATCGTATATCCATG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CACCACCAGAAGTTATTAATTTTACCCATGCATCAGC
GTTTCAATTCCTACAAGGTAAGGTACAAAC

>NC_011653|9|13|1182958-1184387|PILER-CR
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TATGTAGCTGCTTTATCCGTGCTTATACCAACTTTTG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TTAATCCCCTGGATCAAGAACACTTTCTTTATATTCT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	GCAATTTTACTACTTATTCTAATTTTAAAAACAAAG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CGAATAGACTAAATGAATTATTGAAGCAAAACAACTT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAATCCGCTCTCACTAACTATTAATGCAACAAAAATT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TAAAAATCGAAACAGATAGATGTTCCTATTCATTTAT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGAAGTTGTGCGGTCATGTATTCTATTGTTCTTTCAAT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	GCAAATCTGAGACAACTTCAGACCTGATAGCAGAAAT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGAAATTGGAAGAACTAAAAGGAGGTATAAAACAG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CGAACTTGAAAACAAAGTTTCAATAGAGCAAAAAG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TATAACCCATTAGAAACAACAGGCGATGAAAAAGAAA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TAGAAACAGATGGTACAATTAAACCAGCAGAATATA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CCGGATACACTTTAAGTTTCTCTGGCAAATATAAAGT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGGAAGTGTTGAAGTGGCAATTGAAGGAGTTTGCTG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TGACGAAGCGCCTGAAGCATACAAGGACATCATGTA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AATGGTTCTTCCGTAAAAGATAAATAGCCAACAAAA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	ATTTATGGAAACGGTTCCATATGGTATAGTTTGAG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGGAGGTAACATTATGGCACAGAACGTTGTGAATGC
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TAGTTCTTTCACTCAACTCCGCCCCGCGATATTGCTA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGTAACCCTTCAAGACACTTCCATCGTATATCCATG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CACCACCAGAAGTTATTAATTTTACCCATGCATCAGC
GTTTCAATTCCTACAAGGTAAGGTACAAAC

>NC_011653|9|9|1182958-1184387|CRISPRCasFinder
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TATGTAGCTGCTTTATCCGTGCTTATACCAACTTTTG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TTAATCCCCTGGATCAAGAACACTTTCTTTATATTCT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	GCAATTTTACTACTTATTCTAATTTTAAAAACAAAG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CGAATAGACTAAATGAATTATTGAAGCAAAACAACTT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAATCCGCTCTCACTAACTATTAATGCAACAAAAATT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TAAAAATCGAAACAGATAGATGTTCCTATTCATTTAT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGAAGTTGTGCGGTCATGTATTCTATTGTTCTTTCAAT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	GCAAATCTGAGACAACTTCAGACCTGATAGCAGAAAT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGAAATTGGAAGAACTAAAAGGAGGTATAAAACAG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CGAACTTGAAAACAAAGTTTCAATAGAGCAAAAAG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TATAACCCATTAGAAACAACAGGCGATGAAAAAGAAA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TAGAAACAGATGGTACAATTAAACCAGCAGAATATA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CCGGATACACTTTAAGTTTCTCTGGCAAATATAAAGT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGGAAGTGTTGAAGTGGCAATTGAAGGAGTTTGCTG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TGACGAAGCGCCTGAAGCATACAAGGACATCATGTA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AATGGTTCTTCCGTAAAAGATAAATAGCCAACAAAA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	ATTTATGGAAACGGTTCCATATGGTATAGTTTGAG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGGAGGTAACATTATGGCACAGAACGTTGTGAATGC
GTTTCAATTCCTACAAGGTAAGGTACAAAC	TAGTTCTTTCACTCAACTCCGCCCCGCGATATTGCTA
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AAGTAACCCTTCAAGACACTTCCATCGTATATCCATG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	CACCACCAGAAGTTATTAATTTTACCCATGCATCAGC
GTTTCAATTCCTACAAGGTAAGGTACAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011653.1\|WP_012580542.1\|1194022_1195153_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_011653.1\|WP_004101324.1\|1193164_1193734_+\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NC_011653.1\|WP_041427207.1\|1193765_1193972_+\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_004101322.1\|1192409_1193168_+\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|223162
NC_011653.1\|WP_012580041.1\|1177990_1179709_+\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379232
NC_011653.1\|WP_148203272.1\|1175541_1177968_+\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012580038.1\|1173714_1174668_-\|D-glycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|240626
NC_011653.1\|WP_012580043.1\|1180095_1180590_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|225076
NC_011653.1\|WP_012580050.1\|1188279_1189707_+\|PLP-dependent-lyase/thiolase	unknown	unknown	gnl\|CDD\|366004
NC_011653.1\|WP_012580048.1\|1186960_1187962_+\|dihydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|226326
NC_011653.1\|WP_012580044.1\|1180594_1181611_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|377949
NC_011653.1\|WP_012580039.1\|1174774_1175485_+\|SagB/ThcOx-family-dehydrogenase	unknown	unknown	gnl\|CDD\|380318
NC_011653.1\|WP_012580047.1\|1184672_1186631_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|214599
NC_011653.1\|WP_012580036.1\|1171415_1172717_-\|UDP-N-acetylmuramate--L-alanine-ligase	unknown	unknown	gnl\|CDD\|273433
NC_011653.1\|WP_004101320.1\|1190063_1192256_+\|cobalamin-dependent-protein	unknown	unknown	gnl\|CDD\|378113
NC_011653.1\|WP_012580051.1\|1189696_1190071_+\|ornithine-aminomutase-subunit-alpha	unknown	unknown	gnl\|CDD\|374623
NC_011653.1\|WP_012580049.1\|1187978_1188287_+\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012580037.1\|1172713_1173718_-\|UDP-N-acetylglucosamine--N-acetylmuramyl--(pentapeptide)-pyrophosphoryl-undecaprenol-N-acetylglucosamine-transferase	unknown	unknown	gnl\|CDD\|340818
NC_011653.1\|WP_012580045.1\|1181623_1182079_+\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012580046.1\|1182104_1182710_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|319790

Protein	Function_ID	Function_description	E-value
NC_011653.1\|WP_004101324.1\|1193164_1193734_+\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	1.14432e-58
NC_011653.1\|WP_012580542.1\|1194022_1195153_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	4.60903e-47
NC_011653.1\|WP_004101322.1\|1192409_1193168_+\|TatD-family-hydrolase	gnl\|CDD\|223162	COG0084, TatD, Mg-dependent DNase [DNA replication, recombination, and repair].	1.21208e-106
NC_011653.1\|WP_012580041.1\|1177990_1179709_+\|VCBS-repeat-containing-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	4.99901e-06
NC_011653.1\|WP_012580038.1\|1173714_1174668_-\|D-glycerate-dehydrogenase	gnl\|CDD\|240626	cd05301, GDH, D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH). D-glycerate dehydrogenase (GDH, also known as hydroxypyruvate reductase, HPR) catalyzes the reversible reaction of (R)-glycerate + NAD+ to hydroxypyruvate + NADH + H+. In humans, HPR deficiency causes primary hyperoxaluria type 2, characterized by over-excretion of L-glycerate and oxalate in the urine, possibly due to an imbalance in competition with L-lactate dehydrogenase, another formate dehydrogenase (FDH)-like enzyme. GDH, like FDH and other members of the D-specific hydroxyacid dehydrogenase family that also includes L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase, typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann-fold NAD+ binding form, despite often low sequence identity. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	0
NC_011653.1\|WP_012580043.1\|1180095_1180590_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	1.82753e-06
NC_011653.1\|WP_012580050.1\|1188279_1189707_+\|PLP-dependent-lyase/thiolase	gnl\|CDD\|366004	pfam00291, PALP, Pyridoxal-phosphate dependent enzyme. Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.	9.72977e-49
NC_011653.1\|WP_012580044.1\|1180594_1181611_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|377949	pfam07963, N_methyl, Prokaryotic N-terminal methylation motif. This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.	0.00976827
NC_011653.1\|WP_012580039.1\|1174774_1175485_+\|SagB/ThcOx-family-dehydrogenase	gnl\|CDD\|380318	cd02142, McbC_SagB-like_oxidoreductase, oxidase similar to the microcin B17 processing protein McbC. This family is the oxidase domain of NRPS (non-ribosomal peptide synthetase) and other systems that modify polypeptides by cyclizing a thioester to form a ring. These include EpoB, part of the epothilone biosynthesis pathway; TubD, part of the tubulysin biosynthesis pathway, MtsD, part of the myxothiozol biosynthesis pathway; IndC, part of the indigoidine biosynthesis pathway and TfxB, part of the trifitoxin processing pathway. All are FMN-dependent and oxidize the product of the cyclization of thioesters in short polypeptides.	2.25654e-63
NC_011653.1\|WP_012580047.1\|1184672_1186631_-\|HAMP-domain-containing-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.44754e-56
NC_011653.1\|WP_012580036.1\|1171415_1172717_-\|UDP-N-acetylmuramate--L-alanine-ligase	gnl\|CDD\|273433	TIGR01082, UDP-N-acetylmuramate--L-alanine_ligase, UDP-N-acetylmuramate--L-alanine ligase. This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	1.80624e-126
NC_011653.1\|WP_004101320.1\|1190063_1192256_+\|cobalamin-dependent-protein	gnl\|CDD\|378113	pfam09043, Lys-AminoMut_A, D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit. Members of his family are involved in the 1,2 rearrangement of the terminal amino group of DL-lysine and of L-beta-lysine, using adenosylcobalamin (AdoCbl) and pyridoxal-5'-phosphate as co-factors. The structure is predominantly a PLP-binding TIM barrel domain, with several additional alpha-helices and beta-strands at the N and C termini. These helices and strands form an intertwined accessory clamp structure that wraps around the sides of the TIM barrel and extends up toward the Ado ligand of the Cbl co-factor, providing most of the interactions observed between the protein and the Ado ligand of the Cbl, suggesting that its role is mainly in stabilizing AdoCbl in the precatalytic resting state. This is a TIM-barrel domain.	5.94994e-32
NC_011653.1\|WP_012580051.1\|1189696_1190071_+\|ornithine-aminomutase-subunit-alpha	gnl\|CDD\|374623	pfam16552, OAM_alpha, D-ornithine 4,5-aminomutase alpha-subunit. OAM_alpha is the 12.8kDa, alpha subunit of d-ornithine 4,5-aminomutase, or OAM, an enzyme that converts d-ornithine to 2,4-diaminopentanoic acid by way of radical propagation from an adenosylcobalamin to a pyridoxal 5'-phosphate cofactor. OAM is an alpha2-beta2 heterodimer comprising two strongly associating subunits. The packing of the alpha subunits against the beta helps to form the substrate and co-factor binding-regions.	9.55018e-67
NC_011653.1\|WP_012580037.1\|1172713_1173718_-\|UDP-N-acetylglucosamine--N-acetylmuramyl--(pentapeptide)-pyrophosphoryl-undecaprenol-N-acetylglucosamine-transferase	gnl\|CDD\|340818	cd03785, GT28_MurG, undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	6.147e-107
NC_011653.1\|WP_012580048.1\|1186960_1187962_+\|dihydrodipicolinate-reductase	gnl\|CDD\|226326	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown].	6.86635e-47
NC_011653.1\|WP_012580046.1\|1182104_1182710_-\|HAD-family-phosphatase	gnl\|CDD\|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.11464e-41

>NC_011653.1|WP_012580046.1|1182104_1182710_-|HAD-family-phosphatase
MINNIIFDLGRVLINWEPEKYMKKVFDEKTISFLLEKTFNTNDWNLMDKGVIDEQTLWENKLNQYPEYKKEIEHMKNKVLDLLTPIEENAKLLYILKEKGYNLYILSNFSKIAFQKVYEKYDFFKLFDGMIISSHVKSIKPEDEIYKILIEKYKINPAESLYIDDKIENIKAGEKFGFKTIHLEKPEDLKDKLSKILKIDI
>NC_011653.1|WP_012580045.1|1181623_1182079_+|hypothetical-protein
MKKGIINISLGIILIFFSALSALLLSYLFKDAINVEKKIIETVDNTYSKILYISGANIWRKFLTENAAYWDDIQAEFEDASISGNSTRTQLVLNTYLEYNLGSKKKYDYTLVSTTTTYIFEEKYINVIFEILKNGIHVSKGVSFDFGWPGI
>NC_011653.1|WP_012580044.1|1180594_1181611_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MKKGFTFSELLVSMLIIAITFQIVYYIVDNSVESYKNSRINLQNLYAESSISLLFDILENELKYAGSGGELLKELYKPVFVPGDQGSYEQKGEVYSQVTDHCKIANSIDYYEDSQKKEFYITYVVTYKNFFVRNGDGTYSPLYGGDVGKINWVIIKNKLSSSADGYYTRIAKLDADKISGPGTYPGEITPSDIFEFKEINLAKTNKTLSLRNEDKYVYPLYEKSVAFTGYPSVMIKQTKIVFEKESGKIYIERYFPIPDSTSNIYISNILENVEDFDINAMYYSNGIKEKPLSEVDSSFDLSSIFALKFVLTWNAPWKYKSKEFKIIKERIIVLIPNL
>NC_011653.1|WP_012580043.1|1180095_1180590_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MVKTHKGFTLVELLIVIVIISIVMSVSFVGFQTMYKNYSTESKLSGILQNLLFLFIDARRTAIIEDDVVCIRYANGEFSYYIDNNLDGTPDSNVISSFKTDENIKVYLNDEEKSSFLIYTYDSLFFKNNAGVFESSYSNTEIKILLDSREKILKIENSLPKVLE
>NC_011653.1|WP_012580041.1|1177990_1179709_+|VCBS-repeat-containing-protein
MKRFILLSLIFFVLNYLFADVYTAEFPISNWSQQYPEKAWGAIFVKNVSTRVVDKKIVAVNVYKIIDITADPGYGPFGQVSQTFSVDYNKDGYADIISLTYYGLVVIKENKGKKDGELVLENTSYYQLPIENGDGTLIVDDFDNDGKLDLFAYNSWQYAQFVSDVLNSNGEDAVYKRISKDKNFVTKWTVSAMASYDYNGDGYKDVFYIDYKGRVWVWLNDPGQGSERFFDESNIIKLFKDKDLKSDGGGGVLDIGDLNNDGTIDIIVGHTDKKSIFVYFGKIVNNQLTFDTDNKLVLTTSSGKLSDYVITDPSIKNSKSPEILPSFGPTIIKITDVDRDGYKDIFIGTDAWRQGKNFGGSVYLFKGVGITPDNKPKFLSLELVHGSYSKDNNPPYDFDAGTIADLDNDGIPDFVAADGNHSGNYYKIITQTQKEYETSPGYLISDYLTNLVGILPKDLPNNFVKRIKVNIGFDLSLGNGSFEIRYIKNGIKDPSLIDPFGYPLMPDASGTIVENFTTEIEFDKPVPDPQIIIILKPESEFSAPHLKYLKYEIETAPSQVIIKGFNWNKGDN
>NC_011653.1|WP_148203272.1|1175541_1177968_+|hypothetical-protein
MLFIFLLFSVVLFSKALIFEHATVYYPEGYENLAIKVGNIFEDIRDDVVNMFKNDPGRINIFIKTKTTITNGYANPLQNNTIVIYTWHPTGVMYNYLPLDDWYRYLLIHEFTHIVTLKPSDGILKTLSDLKMPYTPSLGKFSVEAPTVFAESSFSENSGRLRNPVISDALFSTFGGTFPQDKIANDFRVGQVFYNGNGGFLEYLVKKYGMEKVNKYLKDSINKSYSWLEIMLNFSIPYVSLIRLPEIFTDDFRAHFGNNFEDEVSEWLNSLNVKFDGEKIYEGKNERIYKIEKVDNKLYILKSKFGAATGYLDNPINELIVLEKGDILTKYNLSALDFKVDSGEIYALVSSNNKTEIWNIGKNEKIVDGFISAFDVYDGKVIYSIYDDKSDESIIYGLSEEIVVNGFVRSIAFDGENLYYLVGNSLYKDNNLIDNYYLKGAFLKKKNDGIYVTMKFDNYMELLDVKNFRLISKGLYAFDGEVSKDEIYYVSYSQNGMAVYKTKFETSTIESVIAENSKLDDYTFRKASFLEEKKYNFLPSLFAPFFLTSSALGDFGGYGGWSVGSIFDFKTSIDSDLVLAPYYLRYFKDYTNFYNEYGLGYAYLLYKDRFSILNAGLFRNTEDYFYGVTEVSFIPFVFRVGYNSNLSLNMDISGFYFATGTSLDYNFNFSPGIVYSNNTFSSSLYLTAYSQLGNNEVFSLSSGVSMLNILNENSYVYGNLVYNFESSTYSYSGIFISNIFPFYKQSGIGVGVNGENDLNGLFYVFVGFPNNNQLYLQSGFEMDMSGKLTLFFGIGAKPHSFYFINEVY
>NC_011653.1|WP_012580039.1|1174774_1175485_+|SagB/ThcOx-family-dehydrogenase
MKSREFLKSNWRQIKNTDREKGIEKPEIEKDCEKVIKLPEFNLGNKPLREVIEERKSIRKYTDTPMSLQELSFLLWATQGVRKYIQDKKVVFRTVPSAGATHPFDTYLVVFNVDGLEKGIYRYVSLKHGLCKVKPGDFKDKIIDATLGQQFVGNSAVVFVWVAVPYRTEWKYTAESYKAIAIDVGHVCQNLYLAATSIDCGTCAVAAYDQEKMDNLIGVDGDNEMVIYLAPVGKIV
>NC_011653.1|WP_012580038.1|1173714_1174668_-|D-glycerate-dehydrogenase
MKVFITYKIPESGINLLKEKFDVDVYEGEKFLTKQEMMERLKDADAVVTQLRDPVDKEFIDAGKKLKIIANYAVGFNNIDVEYAKQKGIYVTNTPDVLTEATADIAWALILAVARKIIPADKFTREGKFEGWKPNLFLGYEIYGKTLGIIGMGRIGKAVARRAMGFGMKIIYHNRKRVEDDYKYNAKYVDLETLLKESDYISINAPLTNETYHLLNKERLSLLKKNAILVNTARGPIIDEKALYELLKDGKIAGAGFDVYENEPEITKGLEKLDNVVLLPHIGSATYETREKMSIMVAENIIDALEGKIPRNLVWKE
>NC_011653.1|WP_012580037.1|1172713_1173718_-|UDP-N-acetylglucosamine--N-acetylmuramyl--(pentapeptide)-pyrophosphoryl-undecaprenol-N-acetylglucosamine-transferase
MIKIAVAGGVTGGHLYPALAVLKELEKLTPIDVLYFTVSGKLEERVLKDYNYKKVSLKIQGLKRPVYSIENIKRLFKIFNANNIVLKELKKFKPDIVFVTGGYVSYPVGTAAKKLKIPLYIQEQNVIPGLANIKLSSFAKKVFVSFEESKKYFQRDVVVAGNPILICHKENLNFEKKTILIVGGSGGSEFLNSLACKLSNKLKDYHFILSSGRKEVPCKSENLTILDYIENMSDYYSAVSCAITRGGATTVSELIFFDTPSIIIPWEGSTEAHQIENAKQIEKLGLGYVIREKEVNIDEIANKIIELSNRERKGSPKTNPAILIAKEIKNEVLK
>NC_011653.1|WP_012580036.1|1171415_1172717_-|UDP-N-acetylmuramate--L-alanine-ligase
MKIHFLGIGGIGMSAQAIHEHFSGNVVSGTDPYSSERVNYLKSLGIQVFKSHLPENIDNADLIVRTPAVSEDNVEVKKAKENGIPVISRLEHHISILRPYTKIGVTGTDGKTTTTAMLAHVLLKLGKDPTVFLGSTHPMLEHGNYRKGSNIAVFEMDESQPGFENYNPDYLIITNIRGDHIENFKNLQHYNSCFENSCKNVKICVSNVENNIINNSIKFGLNDGDYKINKIENNKFSQKITINTPYGKKKFILNVPGVHNALNALSIISLLFEMGYEKDLVLEAFSDFSLPKRRFDISYNENDIVIIDDYSHTPVEIKSLLSTAKSVFKDKKITIIFQPHRYSRLKREWKNFSEALSLADKIYITEVYGAFESKNGISARLIVEKINNAIFVQEKEELLQILPSEPGVYIFAGAGDIIEISKKFKEKVGGLKV
>NC_011653.1|WP_012580047.1|1184672_1186631_-|HAMP-domain-containing-protein
MKNLSLAIKIFIISSILGIFMILLGIYSINSMKSNLVENQKVVLKSDTNHLAEKLWDQINFYSQILNNLELNIKNENIDNIINLFKNTKNGYKNIEFVYVTDGEKIYIYPNIEIPEDFVPTTQPWYQDAIKNRNRIAISEPYEDSIAKKILMTLSKKTSFNDKTAVLAIDIDITKLSEAITSSDSNITHILLSNQGNVILHSNSEFIGASASSTTLFQKLSSSPNQGIFEVKSEDNQNLLVSFSKLPNGWIFTSIVDEDSLLKSINKETINLLIIFIVGFGLSIALGQIISNIYISKPLKNITEVAKNVSEGDLTVKVDYSSKDEIGTLSNSLIQMIESLNQMVKNIETNAKEVEGEAKKVSNFSEISKEQIENLARKFSEIASEATNASAAVQQVTAAVQEVASTAQTVSSAAQNLSENAQNVTELSKKGQNEIINISQIIEQTKEKAEFTQNVVENLSKRAKNINEIVETINSIAEQTNLLALNAAIEAARAGEAGKGFAVVADEIRKLAEESKVATENISKILNEILKESINASQATKETNEIVLTATKQAISVKESFENILNNIMEMTNMVENLAASAQEQSASTEEMSSAMDTINSSILSISSNLEEASNKLAKQEDLIKETFETSKKLFKLSEKLLNSINRFKVKD
>NC_011653.1|WP_012580048.1|1186960_1187962_+|dihydrodipicolinate-reductase
MRIVSWGLGAMGNGIAKNIIQSGYMKLVGAIDLNHAGKDVGEVLGMDKLGIVVSKDKEIIEKTNPDLVVIATSSFVKEVLPQIEYAVKNHCNVVTIAEEMAFPFDSHPEESLYMDSLARRYGVTILGTGVNPGFVLDTLILSLTGVCNRVDKIVARRINDLSPFGKTVMETQGVGTTPEQFEEGLKTGKIVGHIGFPQSIMMIARALGWNITKIEEERKPIISNVHRETPVVKVEPGMVAGCNHSAKAYIGDEVVIEMQHPQQIHPHLEGVETGDYIEIYGDPDIKLAIKPEIPGGKATIAIATNMIPIVIGAEPGLKTMADLPVPRSVLSIK
>NC_011653.1|WP_012580049.1|1187978_1188287_+|hypothetical-protein
MKAKKGDWVQIEKLLLKPEERTAPLPDDTKKVPLKMRVKGFLQNEEANIGDEVEILTLIGRRVTGTLVAINPKYEHDFGEPVPELLTIGIELRKILEGDSDA
>NC_011653.1|WP_012580050.1|1188279_1189707_+|PLP-dependent-lyase/thiolase
MRDLSYDAAMSRKNEIMKKAVGIDYEKFISSEIVFDYERMMQEVGYSLDKVREIQSETGVGNTPLVELKQINRLIKKIAPKGKGARIFIKDEATNPSGSYKDRRASVSVYHAQKHGYKGVIAATSGNYGAAVASQAAKRGLKCIIAQECYDSRWIGQPEILEKARSCEAYGAEVVQLTVGPELFYYTLVLLEETGFFNASLYTPYAIAGVETLGYEIAEQTMQMVGKYPDAVVITHAGGGILTGTARGLKKAGANETEIIAASVNLRGLHMASDNDFNKKYFTTGHTGFGIPFATFPDRSDVPKNAARALRYMDRYLLVTQGEVFYITEMLAQLEGMQRGPAGNTSLAAAFALALEMDDDKVIVVNETEYTGAGKLPSAQLTFARKMGMEIKRGDPIKEDLPGKRIVIPEHPSQIGYIEFDMDEVRKSYVKEVIKRYNKKEFNKQEIEFMAQDTNTSIEKIVDFVKELGGEVIEA
>NC_011653.1|WP_012580051.1|1189696_1190071_+|ornithine-aminomutase-subunit-alpha
MKPRKDDFLERSKHLQKMTDDELNQYFWHLVEKVVDPLIELAKTHTSPSVERSVLLRMGFNSIEASKLVDMIFQRGLLGKGAGHIVWKIAKEKNLDIIEAGRALIEGKYWEDVDRIFKGVNNNA
>NC_011653.1|WP_004101320.1|1190063_1192256_+|cobalamin-dependent-protein
MLDPKKPIDIDEILKDLDKYRPKRKGWTWRKRLPEGSKIGDYEYYQVSENLKNSIPLPAAHYFGNIDPQPEVVITSEIASGRFEDDIRRMRMAAWHGADHIMVIRTLGQSHYDGLIEGTPEGVGGIPITRKQLRATRKALDLIEEEVGRPINFHSYVSGVAGPEIAVLFAEEGVNGAHQDPQYNVLYRGINPIRSFVDAAVAKKIMASVNMLQIDGAHNANASAKLAWTVMPELLVQHGINCMYSLKAGMKKEYIALSTVPPVVAPMPEFRYNLPYAVALRELFDGFRFRAQMNTRYIESDLFDATRIHVLNTLISRLTSADLQSTITPDEGRNVPWHVNSIRGVETAKHTLVALDGMKKYVKIDEKKIREKVRELKMRAILMLEEILDMGGYFEALEAGMFVDNGYYPERIGDGIARKKDGEIAAGTVVPRDEDYMAPVCEHFGYNNLPEGIEKPCDLIGGCTLHNPDKIQFIDELDETDNVNVRLERIRDMKKRNVIKPEVEWFADGWIQLDMTFALPEELAEAAAISLCKKLGLEEITIIHKGVLHPAEGTYIEVKAKVPFEIEVDKLEIPKKPETLPEEEIFEYVKNNPFHVVAGTVGNDEHSVGLREVLDIKHGGIEKYGIKYTYLGTSVPPEKLIDAAIETGAKAILASMIITHNDVHVQNMRKLHELAIEKGIRDKIIIVAGGTQITDDLAKENGMDAGFGRGTKGVHVASFLVKKLKEMENK
>NC_011653.1|WP_004101322.1|1192409_1193168_+|TatD-family-hydrolase
MKIVDTHAHLHMKHFNEDREKIIKNFENDGIEFIVNVATNIEDSYLCIDLSKKYERIFTTVGVHPHDSSNVPDDYLGILEKLAKNEKVVAIGEIGLDYYRNFSPKEVQQKVFAEQLMLAKDLNLPVVVHVRDAYEDAYSILEMIGPFNGVIHSFSGDREYALKFVKLGFYLGIGGPLTYKKNQQLRDIVRLVGEENIVTETDCPYLPPQPYRGKRNEPSYVKYVVEEINKLIGENVSEKLINNARELFGVNI
>NC_011653.1|WP_004101324.1|1193164_1193734_+|Holliday-junction-branch-migration-protein-RuvA
MIHALNGKVESIENGKVYVNVNDLIYEIIVGDTGDFEEYINRNVKIYTKMVVNDDGISLYGFLEVIKLKLFEKLIGVNKLGPKSALKIISSNSVESVVSAIINEDVKALSSLPGIGPKTAERIVLELKDTIKELDVSINEKDRKVLEAIEALVTLGFNRNQAKKAVNKVAAKDDKLDDIIKKALRFLSR
>NC_011653.1|WP_041427207.1|1193765_1193972_+|hypothetical-protein
MLGYKLDPGEPGLSHGAPASRSVLRVLSQELSNYYAFERKAQKEGGYIIYGGIYLDLRNGLNPRKGTK
>NC_011653.1|WP_012580542.1|1194022_1195153_+|IS3-family-transposase
MAKKGQKFKKYPSEIKYQVVKLFIEENLPKKTIASLLGIPPDRVRLWIKNYLLYGDAERKRGKPKKESFEEEMERLRAENAYLKLLMEKILEEGNSKKKIEVINELKERFSLELLCKISGISKSTYYRAMKRKDKDEKLKEEIKDIYFKYKGIYGYRRITMVLNRKGRKINHKKVYRLMKEMGLYARIRKKNHIRKLTLDAQYIADNKLKRNFKSKRPFEKFVSDITQIKTIDGKLYLIIIQDLYNNEIIEYSIGENNNLELVNNTIKRWLKSGKYRKGGILHTDRGFQYTHVLTAKILKEKGIIQSMSRKGVPQDNGPAESFFSHLKEEVVRINGEKTKEEYKKLIEEYIRFYNEERYQARLKNMAPVEYRNHVV

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Crispr_ID: NC_011653_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011653_10

1260669-1262686

TypeI-B

Consensus_repeat	Method
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CRISPRCasFinder
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CRT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	PILER-CR

30 spacers

cas4,cas1,cas2,cas3,cas5,cas7,cas8b1,cas6

The CRISPR arrays of NC_011653_10

>merge|NC_011653|10|1260669-1262686|CRISPRCasFinder,CRT,PILER-CR
GTTTCAATCTTTAATAGGTATGCTAAAAACCAAATGCAAGCAATTAGAAAATTTTATGGTAAAGAATGTTTCAATCCCTAATAGGTATGCTAAAAACAGACACATCTTCATCTCCTTTGTTATTTTTAAAAGAGTTTCAATCCCTAATAGGTATGCTAAAAACCTCGTTTCTTTTACCGAGCTTGGTTGCCACATCTGAGTTTCAATCCCTAATAGGTATGCTAAAAACTTAGATACTTTTTTTGATTTTGAGGGCAATTTTTGGAGTTTCAATCCCTAATAGGTATGCTAAAAACATTCAAATTCACTTATCCTTTTTATCCAGAAGAAGTGTTTCAATCCCTAATAGGTATGCTAAAAACTCTTATCAGAATTACCAACCAAATTCAGCAATTCCTTGTTTCAATCCCTAATAGGTATGCTAAAAACTCTTCATGTCATAGTCATTACTCAGAGACCTCAAAATGGTTTCAATCCCTAATAGGTATGCTAAAAACCAAACAAAGATTACGACGTCAGCGTTAGATTCGACCGTTTCAATCCCTAATAGGTATGCTAAAAACTTTAGTTATGCTATTTAAAAAGTAAAGAGGTGATATAGTTTCAATCCCTAATAGGTATGCTAAAAACTATCAATTTCTGTTGTCCCTCTATTGCCTGTTATATGTTTCAATCCCTAATAGGTATGCTAAAAACAAGGTGGTGGCAGCAATGGATGATATCGCAAAGCAAGGTTTCAATCCCTAATAGGTATGCTAAAAACTCAACTTCTCATTTACTATTGCTTCTACTATTTCGTGTTTCAATCCCTAATAGGTATGCTAAAAACGTATGCCATTGCTCTTCCAGAGAGTGGTTTAATTTTGTTTCAATCCCTAATAGGTATGCTAAAAACAATGAATATAAACATAGATGGATTTGGAATAAAAAGTTTCAATCCCTAATAGGTATGCTAAAAACAAGCGATTTGCTTTATTTTGGCAATGCATACGTTTATTGTTTCAATCCCTAATAGGTATGCTAAAAACTGTCAAAGGAAACAACAGCAGATGAACCAGAAGAATGTTTCAATCCCTAATAGGTATGCTAAAAACTGGGAGAATGGCAAAAAGAGGAAGAAAGTTGAAGTGTTTCAATCCCTAATAGGTATGCTAAAAACTTAAACATTATCACACCTCCTTTCTTTACCAACCTTGTTTCAATCCCTAATAGGTATGCTAAAAACAAGTAATAGTGTGATAATGATTGATGTTGCTACACCTGAGTTTCAATCCCTAATAGGTATGCTAAAAACCTATCATATCAGCTGGAAATGGGGTTGCAAGAGCAAGTTTCAATCCCTAATAGGTATGCTAAAAACCCGGAGGTGACTTCATATATGAGAACTATTGAGTAGTTTCAATCCCTAATAGGTATGCTAAAAACGATTAATCACCGCAACGTTCGAGATAACAGGAGTAAAGTTTCAATCCCTAATAGGTATGCTAAAAACGCAATGGGCTTAGCCCGTTGCCCTTTTTAAAACAAGTTTCAATCCCTAATAGGTATGCTAAAAACAATCACCGCCAATAATTTTGGTTGGTGGGAAATACAGTTTCAATCCCTAATAGGTATGCTAAAAACTTTCGGAACCTTTTTGGTTCCAAACTAACAATCATGGTTTCAATCCCTAATAGGTATGCTAAAAACCTATTTCGTTGTTGCCTCGATTAACAAGGTAACATTGTTTCAATCCCTAATAGGTATGCTAAAAACTGTTTAAGCAAGATAGGCAAGATGTAGAGTTGTTAGAGTTTCAATCCCTAATAGGTATGCTAAAAACTCTTGTTCAAGTTTCACAATGATGTGGTAAATGTATGTTTCAATCCCTAATAGGTATGCTAAAAACATAATTAGTATATTTGAATGGGCAATCGACTTCTTGTTTCAATCCCTAATAGGTATGCTAAAAACTTTCAAGAAAATTCTAGATATAACTCCAGGTTGCCGTTTCAATCCCTAATAGGTATGCTAAAAAC

>NC_011653|10|10|1260669-1262686|CRISPRCasFinder
GTTTCAATCTTTAATAGGTATGCTAAAAAC	CAAATGCAAGCAATTAGAAAATTTTATGGTAAAGAAT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AGACACATCTTCATCTCCTTTGTTATTTTTAAAAGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CTCGTTTCTTTTACCGAGCTTGGTTGCCACATCTGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTAGATACTTTTTTTGATTTTGAGGGCAATTTTTGGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	ATTCAAATTCACTTATCCTTTTTATCCAGAAGAAGT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TCTTATCAGAATTACCAACCAAATTCAGCAATTCCTT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TCTTCATGTCATAGTCATTACTCAGAGACCTCAAAATG
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CAAACAAAGATTACGACGTCAGCGTTAGATTCGACC
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTTAGTTATGCTATTTAAAAAGTAAAGAGGTGATATA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TATCAATTTCTGTTGTCCCTCTATTGCCTGTTATAT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AAGGTGGTGGCAGCAATGGATGATATCGCAAAGCAAG
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TCAACTTCTCATTTACTATTGCTTCTACTATTTCGT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	GTATGCCATTGCTCTTCCAGAGAGTGGTTTAATTTT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AATGAATATAAACATAGATGGATTTGGAATAAAAA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AAGCGATTTGCTTTATTTTGGCAATGCATACGTTTATT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TGTCAAAGGAAACAACAGCAGATGAACCAGAAGAAT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TGGGAGAATGGCAAAAAGAGGAAGAAAGTTGAAGT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTAAACATTATCACACCTCCTTTCTTTACCAACCTT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AAGTAATAGTGTGATAATGATTGATGTTGCTACACCTGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CTATCATATCAGCTGGAAATGGGGTTGCAAGAGCAA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CCGGAGGTGACTTCATATATGAGAACTATTGAGTA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	GATTAATCACCGCAACGTTCGAGATAACAGGAGTAAA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	GCAATGGGCTTAGCCCGTTGCCCTTTTTAAAACAA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AATCACCGCCAATAATTTTGGTTGGTGGGAAATACA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTTCGGAACCTTTTTGGTTCCAAACTAACAATCATG
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CTATTTCGTTGTTGCCTCGATTAACAAGGTAACATT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TGTTTAAGCAAGATAGGCAAGATGTAGAGTTGTTAGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TCTTGTTCAAGTTTCACAATGATGTGGTAAATGTAT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	ATAATTAGTATATTTGAATGGGCAATCGACTTCTT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTTCAAGAAAATTCTAGATATAACTCCAGGTTGCC
GTTTCAATCCCTAATAGGTATGCTAAAAAC

>NC_011653|10|10|1260669-1262686|CRT
GTTTCAATCTTTAATAGGTATGCTAAAAAC	CAAATGCAAGCAATTAGAAAATTTTATGGTAAAGAAT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AGACACATCTTCATCTCCTTTGTTATTTTTAAAAGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CTCGTTTCTTTTACCGAGCTTGGTTGCCACATCTGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTAGATACTTTTTTTGATTTTGAGGGCAATTTTTGGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	ATTCAAATTCACTTATCCTTTTTATCCAGAAGAAGT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TCTTATCAGAATTACCAACCAAATTCAGCAATTCCTT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TCTTCATGTCATAGTCATTACTCAGAGACCTCAAAATG
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CAAACAAAGATTACGACGTCAGCGTTAGATTCGACC
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTTAGTTATGCTATTTAAAAAGTAAAGAGGTGATATA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TATCAATTTCTGTTGTCCCTCTATTGCCTGTTATAT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AAGGTGGTGGCAGCAATGGATGATATCGCAAAGCAAG
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TCAACTTCTCATTTACTATTGCTTCTACTATTTCGT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	GTATGCCATTGCTCTTCCAGAGAGTGGTTTAATTTT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AATGAATATAAACATAGATGGATTTGGAATAAAAA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AAGCGATTTGCTTTATTTTGGCAATGCATACGTTTATT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TGTCAAAGGAAACAACAGCAGATGAACCAGAAGAAT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TGGGAGAATGGCAAAAAGAGGAAGAAAGTTGAAGT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTAAACATTATCACACCTCCTTTCTTTACCAACCTT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AAGTAATAGTGTGATAATGATTGATGTTGCTACACCTGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CTATCATATCAGCTGGAAATGGGGTTGCAAGAGCAA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CCGGAGGTGACTTCATATATGAGAACTATTGAGTA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	GATTAATCACCGCAACGTTCGAGATAACAGGAGTAAA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	GCAATGGGCTTAGCCCGTTGCCCTTTTTAAAACAA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AATCACCGCCAATAATTTTGGTTGGTGGGAAATACA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTTCGGAACCTTTTTGGTTCCAAACTAACAATCATG
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CTATTTCGTTGTTGCCTCGATTAACAAGGTAACATT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TGTTTAAGCAAGATAGGCAAGATGTAGAGTTGTTAGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TCTTGTTCAAGTTTCACAATGATGTGGTAAATGTAT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	ATAATTAGTATATTTGAATGGGCAATCGACTTCTT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTTCAAGAAAATTCTAGATATAACTCCAGGTTGCC
GTTTCAATCCCTAATAGGTATGCTAAAAAC

>NC_011653|10|14|1260736-1262686|PILER-CR
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AGACACATCTTCATCTCCTTTGTTATTTTTAAAAGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CTCGTTTCTTTTACCGAGCTTGGTTGCCACATCTGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTAGATACTTTTTTTGATTTTGAGGGCAATTTTTGGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	ATTCAAATTCACTTATCCTTTTTATCCAGAAGAAGT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TCTTATCAGAATTACCAACCAAATTCAGCAATTCCTT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TCTTCATGTCATAGTCATTACTCAGAGACCTCAAAATG
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CAAACAAAGATTACGACGTCAGCGTTAGATTCGACC
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTTAGTTATGCTATTTAAAAAGTAAAGAGGTGATATA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TATCAATTTCTGTTGTCCCTCTATTGCCTGTTATAT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AAGGTGGTGGCAGCAATGGATGATATCGCAAAGCAAG
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TCAACTTCTCATTTACTATTGCTTCTACTATTTCGT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	GTATGCCATTGCTCTTCCAGAGAGTGGTTTAATTTT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AATGAATATAAACATAGATGGATTTGGAATAAAAA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AAGCGATTTGCTTTATTTTGGCAATGCATACGTTTATT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TGTCAAAGGAAACAACAGCAGATGAACCAGAAGAAT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TGGGAGAATGGCAAAAAGAGGAAGAAAGTTGAAGT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTAAACATTATCACACCTCCTTTCTTTACCAACCTT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AAGTAATAGTGTGATAATGATTGATGTTGCTACACCTGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CTATCATATCAGCTGGAAATGGGGTTGCAAGAGCAA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CCGGAGGTGACTTCATATATGAGAACTATTGAGTA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	GATTAATCACCGCAACGTTCGAGATAACAGGAGTAAA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	GCAATGGGCTTAGCCCGTTGCCCTTTTTAAAACAA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	AATCACCGCCAATAATTTTGGTTGGTGGGAAATACA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTTCGGAACCTTTTTGGTTCCAAACTAACAATCATG
GTTTCAATCCCTAATAGGTATGCTAAAAAC	CTATTTCGTTGTTGCCTCGATTAACAAGGTAACATT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TGTTTAAGCAAGATAGGCAAGATGTAGAGTTGTTAGA
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TCTTGTTCAAGTTTCACAATGATGTGGTAAATGTAT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	ATAATTAGTATATTTGAATGGGCAATCGACTTCTT
GTTTCAATCCCTAATAGGTATGCTAAAAAC	TTTCAAGAAAATTCTAGATATAACTCCAGGTTGCC
GTTTCAATCCCTAATAGGTATGCTAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011653.1\|WP_148203251.1\|1271214_1271364_-\|transposase	unknown	unknown	gnl\|CDD\|225511
NC_011653.1\|WP_004101513.1\|1253276_1253996_+\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012580085.1\|1250571_1251879_+\|trigger-factor	unknown	unknown	gnl\|CDD\|223618
NC_011653.1\|WP_158301510.1\|1269994_1270156_+\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012580095.1\|1262840_1265192_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_011653.1\|WP_148203273.1\|1270099_1270672_-\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|366234
NC_011653.1\|WP_012580099.1\|1268803_1269526_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|187889
NC_011653.1\|WP_041427212.1\|1259994_1260486_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_011653.1\|WP_012580098.1\|1266868_1268782_-\|TIGR02556-family-CRISPR-associated-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	gnl\|CDD\|187861
NC_011653.1\|WP_012580089.1\|1256219_1257539_+\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NC_011653.1\|WP_012580101.1\|1272514_1274779_-\|DUF2194-domain-containing-protein	unknown	unknown	gnl\|CDD\|378327
NC_011653.1\|WP_081429709.1\|1255216_1256134_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_011653.1\|WP_012580100.1\|1271598_1272510_-\|endo-alpha-1,4-polygalactosaminidase	unknown	unknown	gnl\|CDD\|273582
NC_011653.1\|WP_012580090.1\|1258719_1258983_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_011653.1\|WP_012580097.1\|1265967_1266876_-\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	gnl\|CDD\|377458
NC_011653.1\|WP_004101516.1\|1253934_1254789_+\|protein-glutamate-O-methyltransferase-CheR	unknown	unknown	gnl\|CDD\|224271
NC_011653.1\|WP_004101502.1\|1251862_1252468_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NC_011653.1\|WP_012580091.1\|1258986_1259979_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NC_011653.1\|WP_012580086.1\|1252516_1253275_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|234640
NC_011653.1\|WP_012580096.1\|1265252_1265963_-\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641

Protein	Function_ID	Function_description	E-value
NC_011653.1\|WP_012580085.1\|1250571_1251879_+\|trigger-factor	gnl\|CDD\|223618	COG0544, Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones].	3.22737e-38
NC_011653.1\|WP_148203251.1\|1271214_1271364_-\|transposase	gnl\|CDD\|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	4.74442e-08
NC_011653.1\|WP_012580095.1\|1262840_1265192_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	5.33395e-55
NC_011653.1\|WP_148203273.1\|1270099_1270672_-\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	2.97039e-17
NC_011653.1\|WP_012580099.1\|1268803_1269526_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|187889	cd09759, Cas6_I-A, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex; RAMP superfamily protein; Possesses double RRM/ferredoxin fold.	1.0802e-36
NC_011653.1\|WP_041427212.1\|1259994_1260486_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	6.27814e-68
NC_011653.1\|WP_012580098.1\|1266868_1268782_-\|TIGR02556-family-CRISPR-associated-protein	gnl\|CDD\|187861	cd09730, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as TM1802 family.	4.59863e-146
NC_011653.1\|WP_012580089.1\|1256219_1257539_+\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	0
NC_011653.1\|WP_012580101.1\|1272514_1274779_-\|DUF2194-domain-containing-protein	gnl\|CDD\|378327	pfam09960, DUF2194, Uncharacterized protein conserved in bacteria (DUF2194). This domain, found in various hypothetical bacterial proteins, has no known function.	1.94604e-138
NC_011653.1\|WP_081429709.1\|1255216_1256134_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	2.2888e-126
NC_011653.1\|WP_012580100.1\|1271598_1272510_-\|endo-alpha-1,4-polygalactosaminidase	gnl\|CDD\|273582	TIGR01370, Uncharacterized_protein_DR_0705, extracellular protein. Original assignment of this protein family as cysteinyl-tRNA synthetase is controversial, supported by but challenged by and by subsequent discovery of the actual mechanism for synthesizing Cys-tRNA in species where a direct Cys--tRNA ligase was not found. Lingering legacy annotations of members of this family probably should be removed. Evidence against the role includes a signal peptide. This family as been renamed "extracellular protein" to facilitate correction. Members of this family occur in Deinococcus radiodurans (bacterial) and Methanococcus jannaschii (archaeal). A number of homologous but more distantly related proteins are annotated as alpha-1,4 polygalactosaminidases. The function remains unknown. [Unknown function, General].	3.94767e-70
NC_011653.1\|WP_012580090.1\|1258719_1258983_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	6.21596e-33
NC_011653.1\|WP_012580097.1\|1265967_1266876_-\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	8.00203e-72
NC_011653.1\|WP_004101516.1\|1253934_1254789_+\|protein-glutamate-O-methyltransferase-CheR	gnl\|CDD\|224271	COG1352, CheR, Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms].	5.61112e-97
NC_011653.1\|WP_004101502.1\|1251862_1252468_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	2.5442e-145
NC_011653.1\|WP_012580091.1\|1258986_1259979_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	8.8992e-168
NC_011653.1\|WP_012580086.1\|1252516_1253275_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|234640	PRK00110, PRK00110, YebC/PmpR family DNA-binding transcriptional regulator.	8.88736e-148
NC_011653.1\|WP_012580096.1\|1265252_1265963_-\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.86505e-29

>NC_011653.1|WP_041427212.1|1259994_1260486_-|CRISPR-associated-protein-Cas4
MNVGGTLIWYYLICKREVWLMTHEIVPDQYNENIDLGRFIHEFYYKRDKKEIRFGNVVFDILYEKNNRLIIGETKKSSKFSEASKWQLIYYLKILKDAGIIAEGMLSFPEERKKIEVKLSAEAELELEKILKDIDDIINQPNPPKVSKNNFCKNCGYKEYCFS
>NC_011653.1|WP_012580091.1|1258986_1259979_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKDIYIFNSGELKRKDNTICFESSEGKKYLPIENINNLWIFGEVELNKRFLDFASENGILIHFFNFYGYYTGTFYPREHLNSGFVILKQAEHYLDNEKRIKLARKFVEGAVENLLVVLKYYKNRGYELEDEIDDIKNKKEGIYSSQDVETLMSFEGNIRDIYYKCFDKITKKEEFAFEKRSRRPPLNKMNSLISFGNSLLYTTVLGEIYQTQLDPRIGYLHSTNNRRFTLNLDVAEIFKPSIVDRVIFSLVNKNVLSSKDFDKQLNGIVLNNSGKKKFIEEYNKKLETVLKYTKLNAFVSYKRLIRLELYKVQKHITEDEEYQPFVARW
>NC_011653.1|WP_012580090.1|1258719_1258983_-|CRISPR-associated-endonuclease-Cas2
MFVILVYDIGEKRVNKVLKKCRQYLTWVQNSVFEGEITKGGLKKLKMELGRIIEKKEDSVIIYAFENTRYSNREIIGLEKNSLGIIF
>NC_011653.1|WP_012580089.1|1256219_1257539_+|glutamine-synthetase
MGIDEIFKIIEDEKIRFVRLQFSDINGALKNVEIPSADLKRAFEKGIMFDGSSIEGFVRINESDMYLKPDPDTFAILPWTLEGQRSARIICDVYKQDGTPFEGDPRFRLRKVMQEAKDMGFVPHAGPEVEFFLLPRKNNKPSFEFLDEGGYFDLLPVDIAEHLRSEVAVMLEEMGIDVEATHHEVAPSQHEVDFRYSNALSAADAVQTVKLVIKTLAIKNNLYATFMPKPFFGVNGSGMHVHVSLLSTDLQKNMFFDEKSGDISEHMRYFIGGVLKYSKAITAVTNPTVNSYKRLVPGYEAPVNIAWSLANRSALVRVPSARGMATRIEYRSPDPSCNPYLALAVIIKAGLQGIKDKIEPPLPVEKDIYHMKEEEKDNFGIDHLPSNLKEALDEMEKCELIKETLGEHIFNKFLEMKRLEWKDFSIAVTEWERQRYEIV
>NC_011653.1|WP_081429709.1|1255216_1256134_+|RluA-family-pseudouridine-synthase
MEINVTAREKGWRLDKFVQEKAPSWISRTYIQKAIKIGEIRVNDEIKKPSYKLKLGDVVFLEFPEKPKEVEILPENIPLDILYEDKDIVVVNKSAGMITHPTPSFTSGTLVNALMYHCKDFQGISGELRPGIVHRLDKDTSGVIVVAKNDKAHQSLSKQFKDRVTEKVYAAIVKGIVKKDYGTIEVPVGRNPVVRTKMAAVDWGKNALTYFKVLRRFKDATLVFAYPKTGRTHQIRIHMKYIGHPLLGDELYGSGKKDEIYGATRQMLHALRLSFYHPTTEEKMTFVAPLPEDFKRVLKILSEIY
>NC_011653.1|WP_004101516.1|1253934_1254789_+|protein-glutamate-O-methyltransferase-CheR
MSLEDFKKKRDSFQLNSLSGNTQEFSMEEFNWFLEVVKKDFNFDLTGYKPHRVKRRIEMLIRKYGLKSYKEYYELIKKDEKKKDEFFDRMTINVTEFFRNPEKWWELRDKFIPQLLKESGSKFKAWSAGCSTGEEPYSLAILLEELKAPSSAKVHATDIDIGVLTKARMGEYEERSFVSTPPQYLKKYFEVTSRGTYRVKQNVKNRVIFKRHNLLQDRFETGYDLILCRNVVIYFEMETKMELYEKFAKALRPGGILFIGNTERIFNYRQLGFEVASPFIYRKQ
>NC_011653.1|WP_004101513.1|1253276_1253996_+|hypothetical-protein
MKKVVIFFFLFPLTIFSNILGFWVDPFNALYGFSISQNIEFWNIKALLRYDLPVNWEQGFPLLRPEQLDINFELYSETYSVEYGYFHKKIPFYVSVNPYEKNLNIVWGFTGFYGNYSYFNSDIFDFIFNEDMYGFALKYNDYRFFFENSTENILGFEYNGIVVYFDRFGLEFALNINNENMGFYFVPVNGNFGFVLKDNENFLFLNDDEVSFNWKWGEIYVVGGFQKEKRQFSIEFSIW
>NC_011653.1|WP_012580086.1|1252516_1253275_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MSGHNKWANIKHRKAAQDAKKSKIFTKLIREIIVAAKEGGGDPETNPRLRAVLERARAANMPKDTIEKSIKKGTGELEGVDYQEIIYEAYAPAGVALYIYAMTDNKNRTAQELRHLLSKHGGSLAESGSVAWLFERKGIIEIPKEKIADFEEFAMVAIDAGAEDIIEDDPIQVITAPDMLTEVKDKLAENGFEGEAKVTFIPKNTVKVTGADAEKVLKLVSVLEDNDDVQEVYANFEIDDKELEEIMSKLEG
>NC_011653.1|WP_004101502.1|1251862_1252468_+|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MKEIINQYVPMVVESNGKYERAYDIYSRLLKDRIVFLGSAIDDHVANLVVAQLLFLEAEDPDKDIQLYINSPGGSVSAGLAIYDTMQYIKCDVATICIGQAASMGAVLLAGGTKGKRFSLPNSRIMIHQPLGGAEGPAKDVEIMTKELLRIKNKINEILSFHTGQPIERIEKDTDRDFFMTPEEALEYGLIDKVIKPEDRK
>NC_011653.1|WP_012580085.1|1250571_1251879_+|trigger-factor
MEIKELGVDKNIVTKEFIFDSAEIQRAEKRTLNELNRKYTIEGFRKGKVPLSVFKARFGKDFYDYFVFEQLVEETYKSFEEESNLLLIPEIAEKEINSESARIVVNFHKKPVAKVDFEKIKVKVANKDQVLENYLDLRLKTLREENAVLEPKEGPAEFDDLVRVKTYVTNKETGKVLVDGNEDEYVLYKDDERPTIQNLVGHKKGDVVEFDREFQKGEEEKIVYNYKIEILDVYKRILPELTDEFVKNNLAEMHLETLDELKNKILEEGTKIYDDEIKHSIREQILAQLPEATELFISEKTIDYAVRLIVNNMKEEGKYEEYVKKYDSEDKAKEAIREYYVSELKKEAAIEKIAKEYNIERKATDEELEKYAEILAPYWGISVERAKVLVKERAEVRNEVENMIFVDKVLDKISENVEREIVDINKEGGEDEGNN
>NC_011653.1|WP_012580095.1|1262840_1265192_-|CRISPR-associated-helicase/endonuclease-Cas3
MFYSHPDKRLIEHFKEVYEISQEKINDDDLKKCFKIIAYAHDFGKFTTYFQKYLETKKRGKYTDHGFISALFAAFCSLKEFGKESFLPLISYSVVLHHHGDLENVDNHLPISTRGLMNSDYKLIDRIEIFEVQRNDIIKNKDLIIKEYKTIDEQEKYKINFVEYIQEFLECDIVEVLKTLKQIKIRLEKEKSDDVFFIHQLLYSALIAADKLSASGTIIPNEAFASFEKLNEERKVIIKTNTKNLEINAIRNEIFERIQKNLEKYYKKSRIFTITAPTGTGKTFAGFFAAVKLRELLGGNRRIIYSLPFTSIIDQNYEIIYQLHKVLKNFENESSKYIIKHHSLVKPEYRGNEYEYDLLESELLIENWSSGIIVTTFVQLFETLISTRNRMLKKLINIKDSIIILDEIQAMDISLLPLVEYVLEKATELYDLRIILMTATKPYIFKDSIELLDDNEKYFSIFNRTALLPNLSTKKLDDFIKEFKENLQDKSYLIVCNTINSSLEVYDNLKEINRPVFYLSANLLPVHRLEKIRKIKELLSKNEKIILVSTQVVEAGVDIDFDVVIRDIGPLDSIIQCAGRCNRNNLKENGIVYVYSLIPNESNNDLNYGYGRYIYGLTTLQETKKILQKAEKYSEKDYFYLILEYFKSVQENLSKKKSENIIKSIKILNFSDDKNENITPISDFSIIESKPNFVDVFVICDDISEKAFKKFCDIIKIKDYYEKRKKYLEIKSIISNYTISLPIEYHSSFVEQFGLYLIPREIVNDYYDYETGFKRHKKSYDII
>NC_011653.1|WP_012580096.1|1265252_1265963_-|type-I-B-CRISPR-associated-protein-Cas5
MEFLVFDIKGKFAHFRKFYTNSSSLSYSIPPRTTLEGIIAAILGFERDSYYEILNAEKLNIGLKKVTPTRKIIQTLNYIKAKNPGDVYDPDEHTQIPFEIITSNDKVIYKVYVNHIDQRIMEFLEYRLKNNKFYFIPYFGVASFNVSIEFKGKFQVEPKFSEDFVKVSSVIRRSLISSLKVEEEIILLKEKMPRDFSKERTVIEMEDYIFEESGKAIEVKLNSHYYVINEENIVLM
>NC_011653.1|WP_012580097.1|1265967_1266876_-|type-I-B-CRISPR-associated-protein-Cas7/Csh2
MNEKENSKVNNSEILFIYDAQFCNPNGDPDEENRPRMDSEREINLVSDLRLKRYIRDYLYEKGYDIFVRKVDDKPVTAEKRMGEFNNSKEEEILDKLIDVRLFGATMPVRGNNRAYIGPVQFNWGYSLNKVELLEASITSQFATSENTQQGTIGKDFRVKYSLIAFFGVVSGRRAEKTKLKNEDLKLLDEAMVKAIPLQATRSKIGQYPRLYMRVEYTDSETVLGDFRDLIKLEEKVESIRDIKECALDISELVETLNKNKEKINKIYYFVDKNLELKVNGEIKTLKDALKDLGDGKLEEIR
>NC_011653.1|WP_012580098.1|1266868_1268782_-|TIGR02556-family-CRISPR-associated-protein
MLEGIVQIGRALLENKSLIDNLIKELPTTDKKGNPYHVLKLKFSEENLELDVSEEMDSDTVKKYLYIGTADGPNSPQWYASNHKITYFLSETLFNLTNIDFGEPLNQKLKHIFEKFYIDLGSDIKSKYRYALDLSYLDPNVNVRKLYEEYSEQNKGDNKEFLKVLEKEFEKILIKNYGTKLSEFGLFVIYIDGEPLSKYEEYKQKVLKYKSSSKKRKTSSKKENRKDLRCNICGSTENLTDDLKKMKIKYYTNDKITFASELDKNKFYKNMVICQNCLNAILAAETYLDNKLKTKLGDLDLYIFPHFIYGEPLDKSELDLVVDKIINSYNIVKNLKSVKEFEEKIFGITDENRYFLVNFMFFKKSQQATKIRRFIKDVPLFIFNKIAGASKNAREIVEKAIQMNYETYIDLQKIYYLIPVKINAREVTEYKYILDFYENLLTFKPIEKETLIGKFIEAAKVIYLQKNGYNIKKDSLEFYILNSNMLVKFLEKMGNLKGGNTLDTSKLNVKEDIKNYISTMGYDEQQSAMFLLGVLIGEIGNSQYKKYNSDKKPILNKLNFNGIDKSKIIKLANEVFAKLEQEKIRKYHEKTYADMKRLLDENLENWKLNKNENLFYILSGYSYATIKTIMKGETENE
>NC_011653.1|WP_012580099.1|1268803_1269526_-|CRISPR-associated-endoribonuclease-Cas6
MRAILILKFDKPLTLPIHYNHILQAAILNLLSDENYSKFIHDSGFQFGKRHFKMFTFSRLEGRFLIDRERKTITYFEKAQLHISTIEDKFIEYVVNNLLLEGIDIRGERIHVDKIELKLNTTNFGKIITKSPIVAYSTFIVNNRKKTYYYNPKEKEFQEILANNLVKKYIAYFGKEPKNKYFEITPVSNLKESIVIYKGTVIKGWNGIFQISGSDELINIAYDTGLGSKNSQGFGCFEFI
>NC_011653.1|WP_158301510.1|1269994_1270156_+|hypothetical-protein
MRKTHFFTLTIYSSELIVSISFVSLFGDEKSLFTYSGVKYFNEPCGVVVKINV
>NC_011653.1|WP_148203273.1|1270099_1270672_-|DDE-type-integrase/transposase/recombinase
MIINHKKIHRIRKELNLVRNHHYHPNPPRKRPKTHDITKPNLYWESDIKFVPTKYDGHIPILSIIDVFDKSIVGVYIGNSIKAKDFITTLRKVIEYRKVNSEKLIIRTDNGSKFKAKITSAFMKELNITHEFGYKNNPNSQAYIKSFHSSVQYEFVDSIEFDYIEDEYNYYVSYIYFYNNSTWFIKIFNT
>NC_011653.1|WP_148203251.1|1271214_1271364_-|transposase
MKKRNKYSPDFKLQVVKEYSDLSLSDIASKFGIPSANTIDGLNCTLILI
>NC_011653.1|WP_012580100.1|1271598_1272510_-|endo-alpha-1,4-polygalactosaminidase
MENFIKLLTIGILFFLIIQPLSIERAEVPLIYQLQKINLRTIYSYYKPKFLIIDVQDIDEEDIYYIKKLKENGTTILSYLSIGEAEDYRSYWKKEWNKNPPEWLGSENPMWPGNYKVKYWYIEWQNIVFNMIDEILKYEVDGLYLDLIDSFIYWSENGYPKEFTALQMIDFVFHISNYVKSKGNFLVVPQNGENILDYDTSNNYINAIDGIGIESLFFKYTKRIDEKITLNRLKYIQKIQNQGKFVLVTDYIFSPFYDNSKIINEFIELCKKHNFFGYPANKDKKLSDISGALKYFKKEKEAK
>NC_011653.1|WP_012580101.1|1272514_1274779_-|DUF2194-domain-containing-protein
MKKVLVIFLMIISVIIFSQKKFLLLYKGSEQYGEYMLKDYVIPYLEKNKINYELLDVERMNFYRINSNDFSTIITWYYSNALENSVFYLRQLSIFIENGGNFFFFNNIGANADARELNNVFNKIGVHYKYGYKQLSNYNIEYDKNFFTTSPSTDISRPVEEYEVFSKETKIILSFKVNDKKYPMIFLSNNGGGAIFNSFIDKEGNIILDIQKILHYLTNKKVGRENKILVVCDKYDKEFYLEKQFQLKKLLEYAKINFETDYVERFFEYSYIDLTPFRYIIWITDSKFIHTNTIKRFINNGGTLLFITDPYNTPWNKNIVLEKNNIEKILFNKELFFLSNTDEGCEFDINFDIDFNIELDASNIVLANLVGSKPIPAIWYKKEGNGYIGYIYPPIIKKETRGLILQSILEMQDFNISGFLNSFIFYLDDFPIPSYNVTKRDVIDTDFYYKTWWKDIKAFAKSYNIKYTIVTPLSYNGVSNPPFEFSEYLITHFPKDALIEIDNSDFELGLHGYNHLSLTKENWPNSQNIIESLRAAKKFLESILGHKIFLNSYVAPNNLIDEHGVQNLIKALPEVTTIGTTYSSTDEFSEYIIYNNNVVILPRSTYGYYPLKRILISSINTLANFGSFQHFIHPDDFFAKDRNPMQKDWEELITILDRFYYKIKSKMPWLKNYTASEAYPYFLDYLTQKYEYKINENYLEITIPNYSLMPKYFLLKTKLPVEKIIGGEIVSFYLENDIYIIQMQGTRMKIFFLR

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Crispr_ID: NC_011653_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011653_11

1332271-1333053

Orphan

Consensus_repeat	Method
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CRISPRCasFinder
GTTTTCATTCCTCATAGGTAGATTCTAAAC	CRT
GTTTAGAATCTACCTATGAGGAATGAAAAC	PILER-CR

11 spacers

DEDDh

The CRISPR arrays of NC_011653_11

>merge|NC_011653|11|1332271-1333053|CRISPRCasFinder,CRT,PILER-CR
AAATTCATTCCTCATAGGTAGATTCTAAACGAAGACCATTTTACAGCGTGATACGCACTAATCACATTTTTAGTTTTCATTCTTCATAGGTAGATTCTAAACGATACATAGTCAAAACAAAACATGTACTACATATATGTTTTCATTCCTCATAGGTAGATTCTAAACTTGAACAATTTGATGGTTTGTCACTTAGTTCTATTAATCGTCGTTTTCATTCCTCATAGGTAGATTCTAAACACGAATTATAGAACTAGAAGAATATAGATTGGGGATTGAAGCAGAAGTTTTCATTCCTCATAGGTAGATTCTAAACAACATGATGGCATATTACTCAAAAGAGTTACAGGTGGTTTTCATTCCTCATAGGTAGATTCTAAACGGGAATCAGGCGGGGGATATAGCAATACAGGCGATGCCCGGTTTTCATTCCTCATAGGTAGATTCTAAACGGTATGTAACATTAAATAGTATTGGTGTAGATTGGATGTTTTCATTCCTCATAGGTAGATTCTAAACGATATTGATTTTTTTAACGACGAGGAATTAAAAACAGTTTTCATTCCTCATAGGTAGATTCTAAACGGCAAGAGATTACTACATTGAATTCGCAGAACCAATCTAGTTTTCATTCCACATAGGTAGATTCTAAACAAAAAGGAGTTAATAAGAACAAGGCTCGGCATTGGTTTTCATTCCACATAGGTAGATTCTAAACTGATGGTGCGCGCGCAGGCATTGAGGCGAAGGCTAGTTTTCATTCCACATAGGTAGATTCTAAAC

>NC_011653|11|11|1332271-1333053|CRISPRCasFinder
AAATTCATTCCTCATAGGTAGATTCTAAAC	GAAGACCATTTTACAGCGTGATACGCACTAATCACATTTTTA
GTTTTCATTCTTCATAGGTAGATTCTAAAC	GATACATAGTCAAAACAAAACATGTACTACATATAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTGAACAATTTGATGGTTTGTCACTTAGTTCTATTAATCGTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACGAATTATAGAACTAGAAGAATATAGATTGGGGATTGAAGCAGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AACATGATGGCATATTACTCAAAAGAGTTACAGGTG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGGAATCAGGCGGGGGATATAGCAATACAGGCGATGCCCG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGTATGTAACATTAAATAGTATTGGTGTAGATTGGAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GATATTGATTTTTTTAACGACGAGGAATTAAAAACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGCAAGAGATTACTACATTGAATTCGCAGAACCAATCTA
GTTTTCATTCCACATAGGTAGATTCTAAAC	AAAAAGGAGTTAATAAGAACAAGGCTCGGCATTG
GTTTTCATTCCACATAGGTAGATTCTAAAC	TGATGGTGCGCGCGCAGGCATTGAGGCGAAGGCTA
GTTTTCATTCCACATAGGTAGATTCTAAAC

>NC_011653|11|11|1332271-1333053|CRT
AAATTCATTCCTCATAGGTAGATTCTAAAC	GAAGACCATTTTACAGCGTGATACGCACTAATCACATTTTTA
GTTTTCATTCTTCATAGGTAGATTCTAAAC	GATACATAGTCAAAACAAAACATGTACTACATATAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTGAACAATTTGATGGTTTGTCACTTAGTTCTATTAATCGTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACGAATTATAGAACTAGAAGAATATAGATTGGGGATTGAAGCAGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AACATGATGGCATATTACTCAAAAGAGTTACAGGTG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGGAATCAGGCGGGGGATATAGCAATACAGGCGATGCCCG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGTATGTAACATTAAATAGTATTGGTGTAGATTGGAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GATATTGATTTTTTTAACGACGAGGAATTAAAAACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGCAAGAGATTACTACATTGAATTCGCAGAACCAATCTA
GTTTTCATTCCACATAGGTAGATTCTAAAC	AAAAAGGAGTTAATAAGAACAAGGCTCGGCATTG
GTTTTCATTCCACATAGGTAGATTCTAAAC	TGATGGTGCGCGCGCAGGCATTGAGGCGAAGGCTA
GTTTTCATTCCACATAGGTAGATTCTAAAC

>NC_011653|11|15|1332343-1333053|PILER-CR
GTTTTCATTCTTCATAGGTAGATTCTAAAC	GATACATAGTCAAAACAAAACATGTACTACATATAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	TTGAACAATTTGATGGTTTGTCACTTAGTTCTATTAATCGTC
GTTTTCATTCCTCATAGGTAGATTCTAAAC	ACGAATTATAGAACTAGAAGAATATAGATTGGGGATTGAAGCAGAA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	AACATGATGGCATATTACTCAAAAGAGTTACAGGTG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGGAATCAGGCGGGGGATATAGCAATACAGGCGATGCCCG
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGTATGTAACATTAAATAGTATTGGTGTAGATTGGAT
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GATATTGATTTTTTTAACGACGAGGAATTAAAAACA
GTTTTCATTCCTCATAGGTAGATTCTAAAC	GGCAAGAGATTACTACATTGAATTCGCAGAACCAATCTA
GTTTTCATTCCACATAGGTAGATTCTAAAC	AAAAAGGAGTTAATAAGAACAAGGCTCGGCATTG
GTTTTCATTCCACATAGGTAGATTCTAAAC	TGATGGTGCGCGCGCAGGCATTGAGGCGAAGGCTA
GTTTTCATTCCACATAGGTAGATTCTAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011653.1\|WP_004101664.1\|1345952_1346930_+\|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|234780
NC_011653.1\|WP_041427213.1\|1327929_1329537_-\|DNA-primase	unknown	unknown	gnl\|CDD\|273595
NC_011653.1\|WP_012580144.1\|1335326_1339424_+\|PolC-type-DNA-polymerase-III	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|234767
NC_011653.1\|WP_012580143.1\|1331609_1331930_-\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NC_011653.1\|WP_004101641.1\|1333720_1334821_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341031
NC_011653.1\|WP_184618859.1\|1331045_1331315_-\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NC_011653.1\|WP_004101650.1\|1339587_1339860_+\|stage-V-sporulation-protein-S	unknown	unknown	gnl\|CDD\|377254
NC_011653.1\|WP_004101660.1\|1343612_1344767_-\|diaminopimelate-decarboxylase	unknown	unknown	gnl\|CDD\|143501
NC_011653.1\|WP_004101643.1\|1334840_1335314_+\|crossover-junction-endodeoxyribonuclease-RuvC	unknown	unknown	gnl\|CDD\|234587
NC_011653.1\|WP_004101630.1\|1329616_1330015_-\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NC_011653.1\|WP_004101652.1\|1339867_1340098_+\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_004101634.1\|1330500_1331034_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|226129
NC_011653.1\|WP_004101637.1\|1331301_1331613_-\|ribosomal-processing-cysteine-protease-Prp	unknown	unknown	gnl\|CDD\|377307
NC_011653.1\|WP_114702765.1\|1342087_1342186_+\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012580139.1\|1324195_1326760_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226957
NC_011653.1\|WP_012580142.1\|1330034_1330484_-\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NC_011653.1\|WP_012580147.1\|1344763_1345858_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|349882
NC_011653.1\|WP_012580140.1\|1326806_1327922_-\|RNA-polymerase-sigma-factor-RpoD	unknown	unknown	gnl\|CDD\|236413
NC_011653.1\|WP_012580138.1\|1323866_1324076_-\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NC_011653.1\|WP_004101654.1\|1340133_1340994_+\|DUF1385-domain-containing-protein	unknown	unknown	gnl\|CDD\|377780

Protein	Function_ID	Function_description	E-value
NC_011653.1\|WP_004101664.1\|1345952_1346930_+\|phenylalanine--tRNA-ligase-subunit-alpha	gnl\|CDD\|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0
NC_011653.1\|WP_041427213.1\|1327929_1329537_-\|DNA-primase	gnl\|CDD\|273595	TIGR01391, DNA_primase, DNA primase, catalytic core. Members of this family are DNA primase, a ubiquitous bacteria protein. Most members of this family contain nearly two hundred additional residues C-terminal to the region represented here, but conservation between species is poor and the C-terminal region was not included in the seed alignment. This protein contains a CHC2 zinc finger (pfam01807) and a Toprim domain (pfam01751). [DNA metabolism, DNA replication, recombination, and repair].	1.73198e-125
NC_011653.1\|WP_012580144.1\|1335326_1339424_+\|PolC-type-DNA-polymerase-III	gnl\|CDD\|234767	PRK00448, polC, DNA polymerase III PolC; Validated.	0
NC_011653.1\|WP_012580143.1\|1331609_1331930_-\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	4.94696e-40
NC_011653.1\|WP_004101641.1\|1333720_1334821_+\|MFS-transporter	gnl\|CDD\|341031	cd17478, MFS_FsR, Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters. Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.54961e-36
NC_011653.1\|WP_184618859.1\|1331045_1331315_-\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	1.3899e-45
NC_011653.1\|WP_004101650.1\|1339587_1339860_+\|stage-V-sporulation-protein-S	gnl\|CDD\|377254	pfam04232, SpoVS, Stage V sporulation protein S (SpoVS). In Bacillus subtilis this protein interferes with sporulation at an early stage and this inhibitory effect is overcome by SpoIIB and SpoVG. SpoVS seems to play a positive role in allowing progression beyond stage V of sporulation. Null mutations in the spoVS gene block sporulation at stage V, impairing the development of heat resistance and coat assembly.	8.41611e-42
NC_011653.1\|WP_004101660.1\|1343612_1344767_-\|diaminopimelate-decarboxylase	gnl\|CDD\|143501	cd06828, PLPDE_III_DapDC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase. Diaminopimelate decarboxylase (DapDC, EC 4.1.1.20) participates in the last step of lysine biosynthesis. It converts meso-2,6-diaminoheptanedioate to L-lysine. It is a fold type III PLP-dependent enzyme that contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. DapDC exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity.	7.28477e-147
NC_011653.1\|WP_004101643.1\|1334840_1335314_+\|crossover-junction-endodeoxyribonuclease-RuvC	gnl\|CDD\|234587	PRK00039, ruvC, Holliday junction resolvase; Reviewed.	1.10806e-86
NC_011653.1\|WP_004101630.1\|1329616_1330015_-\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	1.5645e-76
NC_011653.1\|WP_004101634.1\|1330500_1331034_-\|ECF-transporter-S-component	gnl\|CDD\|226129	COG3601, COG3601, Predicted membrane protein [Function unknown].	9.00905e-29
NC_011653.1\|WP_004101637.1\|1331301_1331613_-\|ribosomal-processing-cysteine-protease-Prp	gnl\|CDD\|377307	pfam04327, Peptidase_Prp, Cysteine protease Prp. This is a family of cysteine protease that are found to cleave the N-terminus extension of ribosomal subunit L27 in eubacteria. Proteins in this family are distinguished by a pair of invariant histidine and cysteine residues with conserved spacing that form the classic catalytic dyad of a cysteine protease.	1.6541e-30
NC_011653.1\|WP_012580139.1\|1324195_1326760_-\|ABC-transporter-permease	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	2.70553e-13
NC_011653.1\|WP_012580142.1\|1330034_1330484_-\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	1.81336e-94
NC_011653.1\|WP_012580147.1\|1344763_1345858_-\|amidohydrolase	gnl\|CDD\|349882	cd03886, M20_Acy1, M20 Peptidase Aminoacylase 1 family. Peptidase M20 family, Aminoacylase 1 (ACY1; hippuricase; acylase I; amido acid deacylase; IAA-amino acid hydrolase; dehydropeptidase II; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14) subfamily. ACY1 is the most abundant of the aminoacylases, a class of zinc binding homodimeric enzymes involved in the hydrolysis of N-acetylated proteins. It is encoded by the aminoacylase 1 gene (Acy1) on chromosome 3p21 that comprises 15 exons. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity; substrates include indoleacetic acid (IAA) N-conjugates of amino acids, N-acetyl-L-amino acids and aminobenzoylglutamate. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine). ACY1 appears to physically interact with Sphingosine kinase type 1 (SphK1) and may influence its physiological functions; SphK1 and its product sphingosine-1-phosphate have been shown to promote cell growth and inhibit apoptosis of tumor cells. Strong expression of the human gene and its mouse ortholog Acy1 in brain, liver, and kidney, suggest a role of the enzyme in amino acid metabolism of these organs. Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D), resulting in a metabolic disorder manifesting encephalopathy and psychomotor delay.	5.94605e-107
NC_011653.1\|WP_012580140.1\|1326806_1327922_-\|RNA-polymerase-sigma-factor-RpoD	gnl\|CDD\|236413	PRK09210, PRK09210, RNA polymerase sigma factor RpoD; Validated.	5.02405e-154
NC_011653.1\|WP_012580138.1\|1323866_1324076_-\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	7.60954e-23
NC_011653.1\|WP_004101654.1\|1340133_1340994_+\|DUF1385-domain-containing-protein	gnl\|CDD\|377780	pfam07136, DUF1385, Protein of unknown function (DUF1385). This family contains a number of hypothetical bacterial proteins of unknown function approximately 300 residues in length. Some family members are predicted to be metal-dependent.	1.84098e-111

>NC_011653.1|WP_012580143.1|1331609_1331930_-|50S-ribosomal-protein-L21
MYAIVESGGKQFRVEPGKVFFTERVVGKGEGEEVKLDKVLMVKTDDGKVLVGKPYLENVEIKGTIVEHGRARKVIVGKFRPRKNYRRIKGHRQWYTAIKVEEIQVK
>NC_011653.1|WP_004101637.1|1331301_1331613_-|ribosomal-processing-cysteine-protease-Prp
MITCKFFKENGFFEKFLITGHSMYAQKGKDIVCAAVSVVAQHTARYLLKNGASVKIKDGYLDVKNISHDNISQIFVNELIDTLKDLEEQYPKYLKLEVSNDEN
>NC_011653.1|WP_184618859.1|1331045_1331315_-|50S-ribosomal-protein-L27
MMKINIQLFAKSSTAKNGRDSNPKYLGVKRGDGQKVLAGTIIVRQRGTKFWPGKNVGMGRDFTLFALKDGVVKFEVRNNRKYVSVYEEK
>NC_011653.1|WP_004101634.1|1330500_1331034_-|ECF-transporter-S-component
MLNAKRVAIIGVFAALAFVVMYIEIPIFPAVNFLKYDPSDILVLLTAFIYSPTVGVIVLAIKDILFFIFKSQDIVGIAMNFAAGALFIVPAAIIYGKKNRFREILGYIIGTVAATGGMALLNMIVVPYYWKIPLEEVFKLLPWIIGFNAIKFSIDSVINGIIHRRVKNILEPDEAKI
>NC_011653.1|WP_012580142.1|1330034_1330484_-|50S-ribosomal-protein-L13
MARTLPIQKTTLLKKEEVKKDWYLINAEGQTLGRLATRIALVLMGKNKPNWTPHVDCGNFVVVINADKIKLTGKKWDQKIYYRHSGYPGGIKEFTARQLQQRNPEKLIQLAVKRMLPKTILGRKALKRLKIYAGSEHPHSAQKPIELNF
>NC_011653.1|WP_004101630.1|1329616_1330015_-|30S-ribosomal-protein-S9
MAEYYMGTGRRKTSVARVYLKEGNGKVTVNDKEYEDLNGYLENSVWTLHALEPLKVTGLEGSFDLFIRVQGGGKSGQAGAIRLGIARALLQYNPDLRPTLKEKGLLTRDPRMVERKKYGLRKARRAPQFSKR
>NC_011653.1|WP_041427213.1|1327929_1329537_-|DNA-primase
MLKDTIEEIKSKIDIVELISRYVSLQKVGNSYRGLCPFHTETTPSFYVNPSFKTYHCFGCGASGDVIKFVQEIEGIPFMEALKKLANEAGVKIEYSSSNSFQQLYFNFYKEIHKEYMEKLFDEKIALDYLFSRGFSEEEIKEYEFGFSPINSKIPQKIAQKLDIKSLKKFGFSTHDQFEGRLIIPIKNEYSNVIAFGGRLLGEGQPKYLNSYETDFFKKSKTLFLLDIAKDKIKTADFAIICEGYFDAIAFHRADFKNAVATLGTSFTKFHAFSIKKLTQNVILAFDTDSAGIKAALQSIKILISMQFNVMVAGKTKEKDPDEIYKTQGSSGLYSFLKEAIPAEEFIPYVLSKNYDLNNSNAIPLYTREIKNWEKIFENFPEKLETFRKTAEKISKTSITVSVPKPKQKTNLPTLDEMVIYLLLNNPQVDIEINPKIFNELTQEFIKSLKNLKNFSFEKLSKDLQKYIENILNKMEKFEINEDYINTVKKKIEEKTLEKRIEEIDKYLNSATEEEKRVLLQTRMELVRKLKKLGR
>NC_011653.1|WP_012580140.1|1326806_1327922_-|RNA-polymerase-sigma-factor-RpoD
MAKKKTVDSLDSKIEKLIAIGKEKGFVTYEDIDKMFPPEKADEFDGNVLEKVYEELEKNNVAITEETTNDGIEDVTLEDFLEESPKFYDNMATKDLIKMYLKDIGKIPLLSQSMERELARRAQLGDERAKQKLVESNLRLVVSIAKRYVGKGLSFLDLIQEGNVGLLKAVEKFDWKKGYKFSTYATWWIRQAITRAIADQARTIRVPVHMVETINKVQKIMREYYQEHGTEIPIEELAKLIGKPVEKVEEILQAAKETTSLEAPVGEDDDSTVGDFIADETIASPKKEAMRMLIREEVDKVLETLNDREKLVLKMRYGLIDGKAKTLEEVGQYFNVTRERIRQIEVKALRKLRHPSRSRYLKLLFKMLDES
>NC_011653.1|WP_012580139.1|1324195_1326760_-|ABC-transporter-permease
MIKIAFRNFFSNFKLSLLVILGSMIATMLVVGALSLNDSVDSWFNSKLRNNFGNIDIVAKDKSDTFFFPKTLNVEQVEKYLNKYKNEGVVRDFVFTYLVSSRIKHNGNFYDIFAVGYDEKIKEFSKKDIDGIILSSDLAKTLNIKQGDTITIITPSGSKELKIDHIGLEEFNFRGETGMTNGSIFIPKDLMLSLRMYTYNAPNTVFISLNLDLKNHLEFSEKLSKDLDLRTTPTKYNLKYSPLNKVIGYLFLGFSGFSILSSFLFISNFFGVLAEDRRKTLGTLRALGLSKKKSGIILFLEGLMYIISSSIVGALLGIIFGRYLLSFVNNLPNIASSDTTIAEKIPYVITYKSIFLGILISIILPVTLLITRSISFSKIPPVVLLSEEQILPKKRWIFILAFLIVVAFFFINPLYSLSVLIILISIFFKKSYVQLLAGVLSILTIYNKIGTGERWDYLARSGIFLAASVVIIFSILPLIKNVIRKFYSLSNILAISYIEKQKMRNYIVFFVYAIITLVILLTAVIPSSVFNYVDKKLDSGIVGYNFLIIENPLKSFFKTDYYETDENFKSMFENLVKIQLVNAKLDNRNLTIILAKSGIEKSLKIENVKINDLSLKEGIANKEIFSKDSTYTFLIKGILPGISARFYESFKVVDTFDPKNVIVPFDGIFVYDKKVSGALQGYAGVVKDEYVSQAKNTVYEKFDAPLYVTEELNKVFLSIKYFINVAVQLFYFGFISGFSGLTILSLKNVYERKRIIGSLKALGVNRKTVFSFFITEAFLIVTIAILTAIITTFFITMDLTTMISSELPDFLITIPWIQIIEIIAGIYLITGIFTIYPANLAQKISPAEAIRVFD
>NC_011653.1|WP_012580138.1|1323866_1324076_-|50S-ribosomal-protein-L28
MAKCQICGKGPASGKNVSHSNRRTNRWFRPNLQKVRVLREDGTVKRMWVCTDCLSAGKIKRYVSKSVEA
>NC_011653.1|WP_004101641.1|1333720_1334821_+|MFS-transporter
MELLGAIFHFFADFFNAFVKPLAPHFIDKLGIDNKTFASFIALLGGITSIFQVFFGMYFDKIKRDGIYITIIVVLEVFLVSFLGIVKSAILFFSLVVAIRLLNSMFHPLGASFAGRRSKGKHVALFSVAGTLGAGIAPVFITFYQEKIGIEKLYFLTLFFIPFLLLLSFRIFSYEKPVEAKKLSFKGDIFKLWPIFLIVASRSFSMDIFHTYIPIYMNEVGKSLIVGGSILTFGMMFGVFTNFFGTIVLEKTNDKFTNTIGFVGMGIFGLLFVFVPNLWLKVISFVLFDGFSFFTMSSNIVSAQKLLPNNKALASGISMGFSWAIGSFLSSGYAAIFGNNTIFMFLSASVFPLLTILIYNFGVKNN
>NC_011653.1|WP_004101643.1|1334840_1335314_+|crossover-junction-endodeoxyribonuclease-RuvC
MRIIGVDPGYGILGYGILEKNKNKISHVTHGVITTEKDVPMYKRLGYIYDRFVELLEEYSPDACAIESLFFYKNVKTAIHVGEARGVILLASSQRNIPLYEFTPYQVKNNVTGYGRADKKQVQKMVKMLLNLNDIPKPDDAADALAVAWCLAVEIKA
>NC_011653.1|WP_012580144.1|1335326_1339424_+|PolC-type-DNA-polymerase-III
MKYVFPNLNIPITKLSEYFNLELSGEIVKIVYDTKSQSLTFYLNEAIGDLDILSEKLKMFFGVDVFLEYSLPEINKEKILNMLNGNAPYVKDVEFLENEIVIKAFGEFAAKKIESKLKRIESLTKKNVRVEIIEEEISFVPPKVESSLKTFEGGKIKYYFPSNISMNAKGVFLRGKVFKIEKSEYGNPLLSIYVTDNKDSILAKVFDNVDKIETLVSVNNWYYFKGSMSVDRNGEFYFSVKEIYEDPEPIERKDLSQEKRVPLHVHSKMSDLDAIIDIKEFVKRAKEWGWKAVAITDHGNVQSIPYLYEEAKSNEIKPIFGTEMYFLNEPGDIVKNLDKDYVIKDCVYTVFDLETTGTNARFDEIIEFGAVKYKDGKIIDTFKSFVKPNKDINDFTQKLTGITNDMLKDAPGIEEVVPKFLEFIEGTVLVAHNADFDYGFIREVYRKMYDKDLIMPYLDTLKLSKVILKGKVKSFGLGKLVEYFKLGPFKHHRAFEDASVTAELFGKLVELLGKMGIKSLNDINKLKAGTSISSIRTKRVFNHITILVKDKIGLKNLYKLVSDAHVKYFKYVPFVPKNVLKEYKEGLIFGTGCEQGEIFEALKGSATDEEIIELLKEYDYVEIFPLSTIVSVNKEQAKEIFKRLYFLAKRLKMPVVMVDNAHYLEPEDIKARHVLLSPKEKSNPHDEDLRDKDAQLYLRTTDELLKEAIEIFGDEKIAREVVIENPNKIADMIEDIAPVKKKLHPPIIDGAEENVRNLSLKRAKELYGDPLPEVIEKRLEKELKSIIDNGYAVLYEIAHLIVKKANEDGYVVGSRGSVGSSFVAYLMGITEVNPLPPHYICPNCKYLEFSKEVGSGYDLPDKLCPKCGTKLNKTGQDIPFEVFMGFKGDKVPDIDLNFSGEYQERAHNYIVELFGKDNVLRAGTISTIAERSAIGYVRSYMELKDETLNTAEQVRLAEKVAGVKRTTGQHPGGLMIVPKDMTVYDFTPIQYPANKKDSEMCTTHFAYESIHDDLVKLDALGHDDPTMIKLLYEYTGVDPTTVPMDDKETLEIFSSLKPLKVRASDLGTDVGTIGIPEFGTDFVQEMLKETRPKSFAELVRISGLSHGTDVWLNNAQDIIRSGKATLSEVISCRDDIMIYLIKAGVEESTAFKIMENVRKGKGITKEEEDLMREHNVPEWFIESCKKIKYLFPKAHAVAYVSMAFRIAYFKVHFPLAYYAAFFSIKGDEFSIETILKGPNAIKKRLTELSVKMKKDVKEKNEEKVLEAALEMYLRGFSFLPPDILKSDYRRFLIEDNKLRIPLNRIPGVGDSVAYSIVQAREEKEFTSIEDLKKRTKLSKAHITTMKKLKILNNLPETDQSSLFDF
>NC_011653.1|WP_004101650.1|1339587_1339860_+|stage-V-sporulation-protein-S
METLKVSSKSNPNKVAGAIVGSLNKNEKLEIQAIGAGAVNQASKALAVARRFLSEEGKDLYAVPGFIEVEIDGETRTGISFKVYLTKKAE
>NC_011653.1|WP_004101652.1|1339867_1340098_+|hypothetical-protein
MNDLEYIAQSCRDDERLLNIVKDVANMSGEEREDFAKKVRQYFLGKNSEEDNNAYKFFKIILEDENARKILEILGE
>NC_011653.1|WP_004101654.1|1340133_1340994_+|DUF1385-domain-containing-protein
MKVGGQAIIEGVLMMGKKIVIAVRNEKGEIVKEELGKIKNKKVLKIPFVRGLFSLFYSMYFGLKGLDRSAEIATGEEMKKSETFFSIFIAIVVGIGLFVMLPVFLTGLLGVKDDEFLFSLVDGFIRLGLFLLYVWIISFMKDVKRVFQYHGSEHKTIHAYENGDELTVENVKKYSTIHPRCGTNFVMIFLIVAIILFSIFGIYRPLSWVERIVIRIVLIPVVASVSYELLKLFDKFPFLRFLSFPGLLLQKLTTAEPDEKQIEVAIESLKFALEGEEPDEDVEYVG
>NC_011653.1|WP_114702765.1|1342087_1342186_+|hypothetical-protein
MLFLQLFWLIVVFGVSEFVWRNGLKRFTAFGI
>NC_011653.1|WP_004101660.1|1343612_1344767_-|diaminopimelate-decarboxylase
MKEIFQKVADEIGTPVYIYFEKILEERINKVKNVFEEINFFPTFAAKANNNPAILKILKNHGFGVDILGEGELLACKIASIEGDKIVWNGNGKTKEQKDLMKEYKVKYVNVDSKEEFENLWKNEDDFELFLRVNPDIDAKTHPYISTGLKKHKFGVDFKTAEEILKSQKISGVHIHIGSQITDVKPFKEAIEKTLKLCQKYNIEKINIGGGWGIKYKDENELNTQEYKEEIIPLLKNFKLVINELGRFIIAPAGFLLTRVTLIKKTEKKFFVVTESGMNHLLRPALYNAYHEIEVLNNSKDEILADVVGPLCESGDFLAKERKIKKPEIGELLVIKNAGAYGFSMANNYNGTVRPAEVLITKDGKIKLIRKRETFDELFKNVIL
>NC_011653.1|WP_012580147.1|1344763_1345858_-|amidohydrolase
MDSIELRHILHQNPEISFREFETQKILLSALKDLKDERLKIYKIAGTGVIALYEPKKGEPFILYRSDIDGLPIEEETEWEFASKNSNMHACGHDVHMSIAYELIKKILSSNIEKNFVFIFQPGEETGAGARYVLDEIEELDIKLALALHVTDEYDFKTVATTKGVLFASATEIDLTFSGKASHVAFYKSGIDSIYLASKFLTEFYNLTFDKAIARFGKIEGGNARNIVSPQTTLMGSIRSESLKITEEIINKIQEVAKSVVQKDGGEFSISKGSIYPPVIVNDKLYELFREFVQKNNIQFIDCGMKYTGEDFGYFSQEYPSLMFWAGVSKGEKYGLHNPKFLPNDEVILYYADVVFNFLKELEI
>NC_011653.1|WP_004101664.1|1345952_1346930_+|phenylalanine--tRNA-ligase-subunit-alpha
MDEIKQLVDTAKKEIDNAEDLQQLNLIRVKYLGKKGLITSQMKKLKDLSQQERPKFGAVVNKAKSEVEDYLNNRMNELYRIEKQKKYEKLRVDVTLSGARKDRGHLHILTKIQKELEDIFISMGFEVVEGPEVEDTWHNFDALNTPEWHPARDVQDSFYFTDKILLRTHTSPVQVRTMLERKPPLAIISPGRVFRRDYDSTHLPMFTQMEVLYVDKNVTVKHLKYTLEEMARKVFGDSAKVRLKPSFFPFTEPSYEVDILFNGKWLEILGAGMVDPNVFKNVGYDPNEWSGFAFGLGLERIAMVKYGIRDIRDFIKNDVRFLENY

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Crispr_ID: NC_011653_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011653_12

1959890-1963518

TypeI-B

Consensus_repeat	Method
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CRISPRCasFinder
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CRT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	PILER-CR

54 spacers

cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6

The CRISPR arrays of NC_011653_12

>merge|NC_011653|12|1959890-1963518|CRISPRCasFinder,CRT,PILER-CR
TTATCAATTCCTACAAGGTAAAGTAAAAACGACTAAAGGAGTGATGAGTATGATTGAGTTAATTGTATTTCAATTCCTACAAGGTAAGGTACAAACAAGATTTACTACCCTAACACCTAAACCTAATGCACGATTTCAATTCCTACAAGGTAAGGTACAAACACAAGAACCGCCTTCTATAAGTATTGATGCCAAACCAAAATTTCAATTCCTACAAGGTAAGGTACAAACTTTTTTGTCCCAGCACAATACTGCCGTCGTTTCTGATTTGTTTCAATTCCTACAAGGTAAGGTACAAACAATACTCGATATCTTTTTCTCCATTTACATATAGTCGGTTTCAATTCCTACAAGGTAAGGTACAAACGCTTGAAACGTTAAAGGTAGAACGTGAACAAAATTTATTTCAATTCCTACAAGGTAAGGTACAAACATTATTTCGAATGGGAATTTGAACAGCTAAACAACAGTATTTCAATTCCTACAAGGTAAGGTACAAACTAAAAGACAGCGTCTATGAGCAAGTTATAACGCCGAATTTCAATTCCTACAAGGTAAGGTACAAACTCTTTCCAATCCCAATCTTGTAACGGCCAATATTCTATTTCAATTCCTACAAGGTAAGGTACAAACGAAAAAGAGTCTGATGGAGATGATAGCGAGGAAACTCAATTTCAATTCCTACAAGGTAAGGTACAAACTATTATAACCTTTTTCTTTTGCTATTTCAATATATTTATTTCAATTCCTACAAGGTAAGGTACAAACTAGTTTCCACACTTGATTCAGTAGCACAGAAATTAAAATTTCAATTCCTACAAGGTAAGGTACAAACTAGTTTCCACACTTGATTCAGTAGCACAGAAATTAAAATTTCAATTCCTACAAGGTAAGGTACAAACTATATTCTTCGGTAATTTCCCTTTTGATTTTGCAAATATTTCAATTCCTACAAGGTAAGGTACAAACGCATATGACAGCAGCACGACACAAGGAGGGGAAGGTAATTTCAATTCCTACAAGGTAAGGTACAAACTCTAATCCATGAGTTGCATCTATTTGGTCTACCATATTTCAATTCCTACAAGGTAAGGTACAAACGGAAAGAGAGGTGGTATGTTGTTACTGAAAGAAAGTATTTCAATTCCTACAAGGTAAGGTACAAACTTACGTAAAGCCGTTTCATGTTTAATCTTTCTACCAATTTCAATTCCTACAAGGTAAGGTACAAACTTGTATCAAGACAGACAGTTGCGGAAGCGTTAGGAATATTTCAATTCCTACAAGGTAAGGTACAAACCAAATTTGGTTTGTGGCGTCACCAAAAAGTCTAGCGCATTTCAATTCCTACAAGGTAAGGTACAAACAAGTCTTCTGCTGCAGATTTATACTGGTTGAAATGCAATTTCAATTCCTACAAGGTAAGGTACAAACTAGAGCAAGTCAGAATATAGGGAAGGCTAAAGAAATACATTTCAATTCCTACAAGGTAAGGTACAAACTCGTGGAAACTTTACAGGAAATGTTTTATTCATAAAATTTCAATTCCTACAAGGTAAGGTACAAACCTTCATAGTCTTCCAAATCTTGTGTAAAACTGTTGCATTTCAATTCCTACAAGGTAAGGTACAAACTTTTTTATCACTCATACTTACACCTCCTTTTTTATTATTTCAATTCCTACAAGGTAAGGTACAAACTAGCTTCAATGCTAAAACTTTTGTTTTGCAAATCTATATTTCAATTCCTACAAGGTAAGGTACAAACTCGTTTCTTTCCACAGTCCTTGCCAATCTAATGCGTATTTCAATTCCTACAAGGTAAGGTACAAACGCACTTCATCGAATGGTTCTTTTATTCCTAAAAGTATTTCAATTCCTACAAGGTAAGGTACAAACTTACAATAAACGATGATAAATTGCATTATTTAGCTGATTTCAATTCCTACAAGGTAAGGTACAAACATAAGGCAGAAGACAAAACACTGCTTGTAAACAGAGTATTTCAATTCCTACAAGGTAAGGTACAAACGTTGGAAGTGGCTTGTGGAGATATATCAAATTCCAAATTTCAATTCCTACAAGGTAAGGTACAAACGAGATAATAGCAACAGATTATTCACTTATATTTGGATTTCAATTCCTACAAGGTAAGGTACAAACAGCTTCAACCGTTAATCTAAACGATGCAACTTATTAATTTCAATTCCTACAAGGTAAGGTACAAACGTATCTCTGTCAACGCGCATTCAGATACCTCAGGAAAATTTCAATTCCTACAAGGTAAGGTACAAACTGTGCGATCTCCGTTAAAATACTTCTTAATAAAAGATCATTTCAATTCCTACAAGGTAAGGTACAAACTAAATATAAGCGGAAGGTGCGAGAGGGTCTTTGAAAAGATTTCAATTCCTACAAGGTAAGGTACAAACTCGCACCTTCCGCTTATATTTATACCACAGTCTTCCCTATTTCAATTCCTACAAGGTAAGGTACAAACTTGGAACCAGAAAGAGGAATACTTAGAGTTTATAGAATTTCAATTCCTACAAGGTAAGGTACAAACGCGAGACAATTGTATAATTCTTCGTCGATTGGTTCGGATTTCAATTCCTACAAGGTAAGGTACAAACTTGGGTTTTTTAGATTCAAAGTTTGATATTGAAAATATATTTCAATTCCTACAAGGTAAGGTACAAACGTTCTTTCACTCAACTCCACCACGAGATATTGCTAATTTCAATTCCTACAAGGTAAGGTACAAACTTAGTACAATTGTTTAGTATCTTTATTTTATGTCTATTTCAATTCCTACAAGGTAAGGTACAAACGAACTCTTCCCACTCCGTAATAATAACACCGTCATCTTATTTCAATTCCTACAAGGTAAGGTACAAACTACAAAGGAGGGGATTTTTATGGTTAAGTTTAAGGGATTTCAATTCCTACAAGGTAAGGTACAAACAAAACATAACTTATTTTATTAAAAAGTATGCAGAACTATTTCAATTCCTACAAGGTAAGGTACAAACCGTGTACTATTGCGATACAGATTCTATCATTACAGAATTTCAATTCCTACAAGGTAAGGTACAAACGTAACTCGTGGAAACTTTACAGATGTTTTATTCATAGAATTTCAATTCCTACAAGGTAAGGTACAAACGGATTGTGCTCGAAGGCAGTCGGTTCAGTAAAGCTGATTTCAATTCCTACAAGGTAAGGTACAAACATGAGTTCCAAATTTTTCTTGCTCTTGCACAAAAATAATTTCAATTCCTACAAGGTAAGGTACAAACAGAAACACCAGATAAATTTAAAGTAACAAAAGTAGAATTTCAATTCCTACAAGGTAAGGTACAAACTTAGTTATAGCTTTATTTATTAGTAAGAAAAGCAAATTTCAATTCCTACAAGGTAAGGTACAAACCGGTAATCAGGCGTTGCTGTTTCTGTGTAATACCCATTTCAATTCCTACAAGGTAAGGTACAAACCATTACTAATAATAGTGCCAACCCGATTGTAGTAAGAGTATTTCAATTCCTACAAGGTAAGGTACAAACAAAGTTCGGCATTCGTAAAGGATTTCCAAAATATTTATTTCAATTCCTACAAGGTAAGGTACAAAC

>NC_011653|12|12|1959890-1963518|CRISPRCasFinder
TTATCAATTCCTACAAGGTAAAGTAAAAAC	GACTAAAGGAGTGATGAGTATGATTGAGTTAATTGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AAGATTTACTACCCTAACACCTAAACCTAATGCACG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	ACAAGAACCGCCTTCTATAAGTATTGATGCCAAACCAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTTTTTGTCCCAGCACAATACTGCCGTCGTTTCTGATTT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AATACTCGATATCTTTTTCTCCATTTACATATAGTCG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	GCTTGAAACGTTAAAGGTAGAACGTGAACAAAATTT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	ATTATTTCGAATGGGAATTTGAACAGCTAAACAACAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAAAAGACAGCGTCTATGAGCAAGTTATAACGCCGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCTTTCCAATCCCAATCTTGTAACGGCCAATATTCT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GAAAAAGAGTCTGATGGAGATGATAGCGAGGAAACTCA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TATTATAACCTTTTTCTTTTGCTATTTCAATATATTT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAGTTTCCACACTTGATTCAGTAGCACAGAAATTAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAGTTTCCACACTTGATTCAGTAGCACAGAAATTAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TATATTCTTCGGTAATTTCCCTTTTGATTTTGCAAAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GCATATGACAGCAGCACGACACAAGGAGGGGAAGGTA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCTAATCCATGAGTTGCATCTATTTGGTCTACCAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GGAAAGAGAGGTGGTATGTTGTTACTGAAAGAAAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTACGTAAAGCCGTTTCATGTTTAATCTTTCTACCA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTGTATCAAGACAGACAGTTGCGGAAGCGTTAGGAAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CAAATTTGGTTTGTGGCGTCACCAAAAAGTCTAGCGC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AAGTCTTCTGCTGCAGATTTATACTGGTTGAAATGCA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAGAGCAAGTCAGAATATAGGGAAGGCTAAAGAAATAC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCGTGGAAACTTTACAGGAAATGTTTTATTCATAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CTTCATAGTCTTCCAAATCTTGTGTAAAACTGTTGC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTTTTTATCACTCATACTTACACCTCCTTTTTTATT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAGCTTCAATGCTAAAACTTTTGTTTTGCAAATCTAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCGTTTCTTTCCACAGTCCTTGCCAATCTAATGCGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GCACTTCATCGAATGGTTCTTTTATTCCTAAAAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTACAATAAACGATGATAAATTGCATTATTTAGCTG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	ATAAGGCAGAAGACAAAACACTGCTTGTAAACAGAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GTTGGAAGTGGCTTGTGGAGATATATCAAATTCCAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GAGATAATAGCAACAGATTATTCACTTATATTTGG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AGCTTCAACCGTTAATCTAAACGATGCAACTTATTA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GTATCTCTGTCAACGCGCATTCAGATACCTCAGGAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TGTGCGATCTCCGTTAAAATACTTCTTAATAAAAGATC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAAATATAAGCGGAAGGTGCGAGAGGGTCTTTGAAAAG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCGCACCTTCCGCTTATATTTATACCACAGTCTTCCCT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTGGAACCAGAAAGAGGAATACTTAGAGTTTATAGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GCGAGACAATTGTATAATTCTTCGTCGATTGGTTCGG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTGGGTTTTTTAGATTCAAAGTTTGATATTGAAAATAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GTTCTTTCACTCAACTCCACCACGAGATATTGCTA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTAGTACAATTGTTTAGTATCTTTATTTTATGTCT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GAACTCTTCCCACTCCGTAATAATAACACCGTCATCTT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TACAAAGGAGGGGATTTTTATGGTTAAGTTTAAGGG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AAAACATAACTTATTTTATTAAAAAGTATGCAGAACT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CGTGTACTATTGCGATACAGATTCTATCATTACAGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GTAACTCGTGGAAACTTTACAGATGTTTTATTCATAGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GGATTGTGCTCGAAGGCAGTCGGTTCAGTAAAGCTG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	ATGAGTTCCAAATTTTTCTTGCTCTTGCACAAAAATA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AGAAACACCAGATAAATTTAAAGTAACAAAAGTAGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTAGTTATAGCTTTATTTATTAGTAAGAAAAGCAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CGGTAATCAGGCGTTGCTGTTTCTGTGTAATACCC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CATTACTAATAATAGTGCCAACCCGATTGTAGTAAGAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AAAGTTCGGCATTCGTAAAGGATTTCCAAAATATTT
ATTTCAATTCCTACAAGGTAAGGTACAAAC

>NC_011653|12|12|1959890-1963518|CRT
TTATCAATTCCTACAAGGTAAAGTAAAAAC	GACTAAAGGAGTGATGAGTATGATTGAGTTAATTGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AAGATTTACTACCCTAACACCTAAACCTAATGCACG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	ACAAGAACCGCCTTCTATAAGTATTGATGCCAAACCAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTTTTTGTCCCAGCACAATACTGCCGTCGTTTCTGATTT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AATACTCGATATCTTTTTCTCCATTTACATATAGTCG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	GCTTGAAACGTTAAAGGTAGAACGTGAACAAAATTT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	ATTATTTCGAATGGGAATTTGAACAGCTAAACAACAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAAAAGACAGCGTCTATGAGCAAGTTATAACGCCGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCTTTCCAATCCCAATCTTGTAACGGCCAATATTCT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GAAAAAGAGTCTGATGGAGATGATAGCGAGGAAACTCA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TATTATAACCTTTTTCTTTTGCTATTTCAATATATTT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAGTTTCCACACTTGATTCAGTAGCACAGAAATTAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAGTTTCCACACTTGATTCAGTAGCACAGAAATTAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TATATTCTTCGGTAATTTCCCTTTTGATTTTGCAAAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GCATATGACAGCAGCACGACACAAGGAGGGGAAGGTA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCTAATCCATGAGTTGCATCTATTTGGTCTACCAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GGAAAGAGAGGTGGTATGTTGTTACTGAAAGAAAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTACGTAAAGCCGTTTCATGTTTAATCTTTCTACCA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTGTATCAAGACAGACAGTTGCGGAAGCGTTAGGAAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CAAATTTGGTTTGTGGCGTCACCAAAAAGTCTAGCGC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AAGTCTTCTGCTGCAGATTTATACTGGTTGAAATGCA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAGAGCAAGTCAGAATATAGGGAAGGCTAAAGAAATAC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCGTGGAAACTTTACAGGAAATGTTTTATTCATAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CTTCATAGTCTTCCAAATCTTGTGTAAAACTGTTGC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTTTTTATCACTCATACTTACACCTCCTTTTTTATT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAGCTTCAATGCTAAAACTTTTGTTTTGCAAATCTAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCGTTTCTTTCCACAGTCCTTGCCAATCTAATGCGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GCACTTCATCGAATGGTTCTTTTATTCCTAAAAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTACAATAAACGATGATAAATTGCATTATTTAGCTG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	ATAAGGCAGAAGACAAAACACTGCTTGTAAACAGAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GTTGGAAGTGGCTTGTGGAGATATATCAAATTCCAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GAGATAATAGCAACAGATTATTCACTTATATTTGG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AGCTTCAACCGTTAATCTAAACGATGCAACTTATTA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GTATCTCTGTCAACGCGCATTCAGATACCTCAGGAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TGTGCGATCTCCGTTAAAATACTTCTTAATAAAAGATC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAAATATAAGCGGAAGGTGCGAGAGGGTCTTTGAAAAG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCGCACCTTCCGCTTATATTTATACCACAGTCTTCCCT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTGGAACCAGAAAGAGGAATACTTAGAGTTTATAGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GCGAGACAATTGTATAATTCTTCGTCGATTGGTTCGG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTGGGTTTTTTAGATTCAAAGTTTGATATTGAAAATAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GTTCTTTCACTCAACTCCACCACGAGATATTGCTA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTAGTACAATTGTTTAGTATCTTTATTTTATGTCT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GAACTCTTCCCACTCCGTAATAATAACACCGTCATCTT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TACAAAGGAGGGGATTTTTATGGTTAAGTTTAAGGG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AAAACATAACTTATTTTATTAAAAAGTATGCAGAACT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CGTGTACTATTGCGATACAGATTCTATCATTACAGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GTAACTCGTGGAAACTTTACAGATGTTTTATTCATAGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GGATTGTGCTCGAAGGCAGTCGGTTCAGTAAAGCTG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	ATGAGTTCCAAATTTTTCTTGCTCTTGCACAAAAATA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AGAAACACCAGATAAATTTAAAGTAACAAAAGTAGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTAGTTATAGCTTTATTTATTAGTAAGAAAAGCAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CGGTAATCAGGCGTTGCTGTTTCTGTGTAATACCC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CATTACTAATAATAGTGCCAACCCGATTGTAGTAAGAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AAAGTTCGGCATTCGTAAAGGATTTCCAAAATATTT
ATTTCAATTCCTACAAGGTAAGGTACAAAC

>NC_011653|12|16|1959956-1963518|PILER-CR
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AAGATTTACTACCCTAACACCTAAACCTAATGCACG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	ACAAGAACCGCCTTCTATAAGTATTGATGCCAAACCAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTTTTTGTCCCAGCACAATACTGCCGTCGTTTCTGATTT
GTTTCAATTCCTACAAGGTAAGGTACAAAC	AATACTCGATATCTTTTTCTCCATTTACATATAGTCG
GTTTCAATTCCTACAAGGTAAGGTACAAAC	GCTTGAAACGTTAAAGGTAGAACGTGAACAAAATTT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	ATTATTTCGAATGGGAATTTGAACAGCTAAACAACAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAAAAGACAGCGTCTATGAGCAAGTTATAACGCCGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCTTTCCAATCCCAATCTTGTAACGGCCAATATTCT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GAAAAAGAGTCTGATGGAGATGATAGCGAGGAAACTCA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TATTATAACCTTTTTCTTTTGCTATTTCAATATATTT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAGTTTCCACACTTGATTCAGTAGCACAGAAATTAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAGTTTCCACACTTGATTCAGTAGCACAGAAATTAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TATATTCTTCGGTAATTTCCCTTTTGATTTTGCAAAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GCATATGACAGCAGCACGACACAAGGAGGGGAAGGTA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCTAATCCATGAGTTGCATCTATTTGGTCTACCAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GGAAAGAGAGGTGGTATGTTGTTACTGAAAGAAAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTACGTAAAGCCGTTTCATGTTTAATCTTTCTACCA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTGTATCAAGACAGACAGTTGCGGAAGCGTTAGGAAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CAAATTTGGTTTGTGGCGTCACCAAAAAGTCTAGCGC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AAGTCTTCTGCTGCAGATTTATACTGGTTGAAATGCA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAGAGCAAGTCAGAATATAGGGAAGGCTAAAGAAATAC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCGTGGAAACTTTACAGGAAATGTTTTATTCATAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CTTCATAGTCTTCCAAATCTTGTGTAAAACTGTTGC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTTTTTATCACTCATACTTACACCTCCTTTTTTATT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAGCTTCAATGCTAAAACTTTTGTTTTGCAAATCTAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCGTTTCTTTCCACAGTCCTTGCCAATCTAATGCGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GCACTTCATCGAATGGTTCTTTTATTCCTAAAAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTACAATAAACGATGATAAATTGCATTATTTAGCTG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	ATAAGGCAGAAGACAAAACACTGCTTGTAAACAGAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GTTGGAAGTGGCTTGTGGAGATATATCAAATTCCAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GAGATAATAGCAACAGATTATTCACTTATATTTGG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AGCTTCAACCGTTAATCTAAACGATGCAACTTATTA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GTATCTCTGTCAACGCGCATTCAGATACCTCAGGAAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TGTGCGATCTCCGTTAAAATACTTCTTAATAAAAGATC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TAAATATAAGCGGAAGGTGCGAGAGGGTCTTTGAAAAG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TCGCACCTTCCGCTTATATTTATACCACAGTCTTCCCT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTGGAACCAGAAAGAGGAATACTTAGAGTTTATAGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GCGAGACAATTGTATAATTCTTCGTCGATTGGTTCGG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTGGGTTTTTTAGATTCAAAGTTTGATATTGAAAATAT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GTTCTTTCACTCAACTCCACCACGAGATATTGCTA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTAGTACAATTGTTTAGTATCTTTATTTTATGTCT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GAACTCTTCCCACTCCGTAATAATAACACCGTCATCTT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TACAAAGGAGGGGATTTTTATGGTTAAGTTTAAGGG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AAAACATAACTTATTTTATTAAAAAGTATGCAGAACT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CGTGTACTATTGCGATACAGATTCTATCATTACAGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GTAACTCGTGGAAACTTTACAGATGTTTTATTCATAGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	GGATTGTGCTCGAAGGCAGTCGGTTCAGTAAAGCTG
ATTTCAATTCCTACAAGGTAAGGTACAAAC	ATGAGTTCCAAATTTTTCTTGCTCTTGCACAAAAATA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AGAAACACCAGATAAATTTAAAGTAACAAAAGTAGA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	TTAGTTATAGCTTTATTTATTAGTAAGAAAAGCAA
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CGGTAATCAGGCGTTGCTGTTTCTGTGTAATACCC
ATTTCAATTCCTACAAGGTAAGGTACAAAC	CATTACTAATAATAGTGCCAACCCGATTGTAGTAAGAGT
ATTTCAATTCCTACAAGGTAAGGTACAAAC	AAAGTTCGGCATTCGTAAAGGATTTCCAAAATATTT
ATTTCAATTCCTACAAGGTAAGGTACAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011653.1\|WP_004103012.1\|1948176_1951236_+\|hypothetical-protein	unknown	unknown	unknown
NC_011653.1\|WP_012580496.1\|1958465_1959728_+\|TrpB-like-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|237087
NC_011653.1\|WP_012580507.1\|1968599_1969505_-\|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NC_011653.1\|WP_012580504.1\|1964957_1965434_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_011653.1\|WP_012580494.1\|1956809_1957493_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_011653.1\|WP_012580510.1\|1972365_1972857_-\|tryptophan-rich-sensory-protein	unknown	unknown	gnl\|CDD\|320706
NC_011653.1\|WP_012580493.1\|1951253_1953413_+\|glycoside-hydrolase-family-3-protein	unknown	unknown	gnl\|CDD\|224389
NC_011653.1\|WP_012580508.1\|1969518_1971213_-\|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl\|CDD\|187822
NC_011653.1\|WP_012580511.1\|1974853_1976107_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NC_011653.1\|WP_012580492.1\|1946249_1947251_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380513
NC_011653.1\|WP_004103016.1\|1953496_1954108_-\|DUF2202-domain-containing-protein	unknown	unknown	gnl\|CDD\|313233
NC_011653.1\|WP_012580509.1\|1971225_1971960_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NC_011653.1\|WP_012580505.1\|1965430_1967836_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_011653.1\|WP_004103022.1\|1955473_1956793_-\|transglutaminase-domain-containing-protein	unknown	unknown	gnl\|CDD\|376628
NC_011653.1\|WP_012580503.1\|1963956_1964952_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NC_011653.1\|WP_012580502.1\|1963693_1963954_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_011653.1\|WP_004103019.1\|1954427_1955459_-\|dipeptide-epimerase	unknown	unknown	gnl\|CDD\|239435
NC_011653.1\|WP_012580506.1\|1967813_1968587_-\|CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NC_011653.1\|WP_012580495.1\|1957510_1958128_-\|pyroglutamyl-peptidase-I	unknown	unknown	gnl\|CDD\|237299
NC_011653.1\|WP_004103010.1\|1947263_1948154_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381318

Protein	Function_ID	Function_description	E-value
NC_011653.1\|WP_012580496.1\|1958465_1959728_+\|TrpB-like-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|237087	PRK12391, PRK12391, TrpB-like pyridoxal phosphate-dependent enzyme.	0
NC_011653.1\|WP_012580507.1\|1968599_1969505_-\|type-I-CRISPR-associated-protein-Cas7	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	2.66291e-27
NC_011653.1\|WP_012580504.1\|1964957_1965434_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.05044e-59
NC_011653.1\|WP_012580494.1\|1956809_1957493_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.31105e-33
NC_011653.1\|WP_012580510.1\|1972365_1972857_-\|tryptophan-rich-sensory-protein	gnl\|CDD\|320706	cd15904, TSPO_MBR, Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family. This family contains tryptophan-rich translocator protein (TSPO), an integral membrane protein that is highly conserved from bacteria to mammals. In eukaryotes, it is mainly found in the outer mitochondrial membranes of steroid-synthesizing cells of the nervous system where it transports cholesterol into mitochondria. It is known to be highly expressed in metastatic cancer, steriodogenic tissues, as well as inflammatory and neurological diseases such as Alzheimer's and Parkinson's. TSPO is also known as the peripheral benzodiazepine receptor (MBR) and its ligands include benzodiazepine drugs, implicated in regulating apoptosis. In human, a single polymorphism A147T is associated with psychiatric disorders; the mutation causes structural changes in a region implicated in cholesterol binding. TSPO is homologous to bacterial tryptophan-rich sensory proteins, and their tryptophan residues are believed to be functionally important. In bacteria, TSPO acts as a negative regulator of expression of specific photosynthesis genes in response to oxygen/light; it catalyzes a photooxidative degradation of Proto porphyrine (PpIX). R. sphaeroides TSPO (RsTSPO) is involved in porphyrin transport, similar to human, while Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.	5.97834e-37
NC_011653.1\|WP_012580493.1\|1951253_1953413_+\|glycoside-hydrolase-family-3-protein	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	7.50849e-82
NC_011653.1\|WP_012580508.1\|1969518_1971213_-\|hypothetical-protein	gnl\|CDD\|187822	cd09691, Cas8b_I-B, CRISPR/Cas system-associated protein Cas8b. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-B subtype; also known as Csh1 family.	0.00347322
NC_011653.1\|WP_012580511.1\|1974853_1976107_+\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.08926e-47
NC_011653.1\|WP_012580492.1\|1946249_1947251_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|380513	cd06290, PBP1_LacI-like, ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.38564e-127
NC_011653.1\|WP_004103016.1\|1953496_1954108_-\|DUF2202-domain-containing-protein	gnl\|CDD\|313233	pfam09968, DUF2202, Uncharacterized protein domain (DUF2202). This domain, found in various hypothetical archaeal proteins, has no known function.	1.47971e-77
NC_011653.1\|WP_012580509.1\|1971225_1971960_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	4.11222e-29
NC_011653.1\|WP_012580505.1\|1965430_1967836_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	9.94479e-40
NC_011653.1\|WP_004103022.1\|1955473_1956793_-\|transglutaminase-domain-containing-protein	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	7.27826e-24
NC_011653.1\|WP_012580503.1\|1963956_1964952_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	3.11443e-155
NC_011653.1\|WP_012580502.1\|1963693_1963954_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.11941e-26
NC_011653.1\|WP_004103019.1\|1954427_1955459_-\|dipeptide-epimerase	gnl\|CDD\|239435	cd03319, L-Ala-DL-Glu_epimerase, L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of the murein peptide of peptidoglycan, of which L-Ala-D-Glu is a component. L-Ala-D/L-Glu epimerase is a member of the enolase-superfamily, which is characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	2.37267e-108
NC_011653.1\|WP_012580506.1\|1967813_1968587_-\|CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.65843e-16
NC_011653.1\|WP_012580495.1\|1957510_1958128_-\|pyroglutamyl-peptidase-I	gnl\|CDD\|237299	PRK13197, PRK13197, pyrrolidone-carboxylate peptidase; Provisional.	4.46727e-117
NC_011653.1\|WP_004103010.1\|1947263_1948154_+\|aldo/keto-reductase	gnl\|CDD\|381318	cd19092, AKR_BsYcsN_EcYdhF-like, Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins. Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.	7.08175e-147

>NC_011653.1|WP_012580496.1|1958465_1959728_+|TrpB-like-pyridoxal-phosphate-dependent-enzyme
MREYVHLNYDEMPKSWYNVLPDLPFKLDPPLDPETQKPMTPEKLLKIFPGPLLEQEANDVDRFIDMPEEILKEYAVYRPTPLIRAKFLEEFLETPVKIYYKYEGVSPTGSHKTNTALAQAYFNKISGTEILYTETGAGQWGSALSYAGVKYGLRVNVYMVRVSYLQKPARKNLINLFEGNVTPSPSRNTKVGRKYPEDHPGSLGIAISEAMEEVFDKDNAKYALGSVLNHVLLHQTVIGLEIKKQLEKLELKPDIIIGCHGGGSNFGGTILPFIPEKLSGENLRFIACEPESCPTLTKGEYRYDFGDTAGFTPMLKMYTLGKDFIPPSIHAGGLRYHGAAPIISALLKNNLIEAQTFSQDETFKAAKLFSKIEGIIPAPESAHAIAGAIREALNAKKEGKGKVIVFTLSGHGLFDLNAYV
>NC_011653.1|WP_012580495.1|1957510_1958128_-|pyroglutamyl-peptidase-I
MKILITGFEPFGGEVVNPSFEAVKHLPDSIEKAQIVKAAIHTVFRKSIEVLEELIVKEKPDIVICVGQAGGRAEITIERVAINIDDAKNPDNEGNTPKDEVIFEDGENAYFSNLPIKKMVEEIKNCKIPASISNSAGTYVCNHLMYGLLYLINKKYKNMKGGFIHVPYLPQQVLNKKNVPSMSLDNIVQALVCSIKAILKEYNDE
>NC_011653.1|WP_012580494.1|1956809_1957493_-|Crp/Fnr-family-transcriptional-regulator
MEIFSYESIFDKEKQNELRNVFLALAKKGKQIEVGKNCEIELSNESSIAIVVEGKLKQSLTNKEGLEKILFYLQPGEIFGEVDYFGETKFNTITIAVVNSKISILEKKIIEEQLTASPILYRYFMKSIIRKLRIIEFQMLNMTFNDSIGRISNTLLRLAAQQGIKKDGKVIINFPLTQQELANIIGCSRITVTRTFKDLISKGIISIKNKKIIIKNLKELEKLDKSF
>NC_011653.1|WP_004103022.1|1955473_1956793_-|transglutaminase-domain-containing-protein
MKFLTTPIPKDIEKLINLGMFKQVKENILKRFKKPIPESLKERLKFELFRLELLEKAYPYNEKEAFELFKKLFKNAKKQEFEKLLEDGYIDFRFINGEKRFQERFHYNVGFTLKEYKERQKKDKSRRNLRKLTNDTIVRLLKTKQEKTYSVSAKISIKRKNPKNEDVCVWLPVPFEKFQQTSVKITNASHDYILSSPTTLQKTVHMKGKDTETFWVEFSYNISEWIGENSKYKYKPTKADLSEKPPHVLFTPYLKEVLQKILKAVKPNNDYEIAKSIYDYLTKNVYYSYVLPYALYDNIPEYVTTVFRGDCGFYAVTFITLCRLAGIPAKWQSGWFATPSGASPHDWALVYLKDFGWVPADLSFGGSRRDNEEMRMFYFGNLDGFRMFANLDFQADFSPKKKYFRNDPYDNQVGEMESKDGYIIDTESEIEILSFKEVK
>NC_011653.1|WP_004103019.1|1954427_1955459_-|dipeptide-epimerase
MGKIKSVKFKLNVFEYEKPFHITNSISTKTSNIEVRIELENGILGFGEASPSFRVNGEKVEALLALEPVINEMIKGYDTKNYRQIFDITDKLFAFPSIKAAVQYAVLDALSEEIDLPVYKILGGAKGKIETDKTVSIGTLEERVNDATKIFEEGFRIIKIKVGENLREDIETIERIYEKTSGAKYIVDANMGYTPKEAITFVNELYKKGIDINVFEQPVKMHDIEGLKFVRFHSPFPVGADESAKTKYDVMRLIKEEAVDYVNIKLMKSGISDALAIVEIVKAANLHLMIGCMGESSLGINQSVHFALGTGAFDFHDLDSALIIKEENFRGKYKTEIPYHIAI
>NC_011653.1|WP_004103016.1|1953496_1954108_-|DUF2202-domain-containing-protein
MKKVIAFAVLNFLSIVLFAGNLTVDKQVNSLPYETLSASEVEGIMQMREEEKLARDVYLELYKTWDLPVFYNIAQSEQTHMDAVKTLIEKYNLKDPITDEDFENIGVFKNEELQNLFNELLSLGEKSLSDALKVGATIEDLDIFDLEELLKSTDNEDIKFIYNNLMKGSENHMRSFIKNLDKLGKTYTPQFISLERFREILKF
>NC_011653.1|WP_012580493.1|1951253_1953413_+|glycoside-hydrolase-family-3-protein
MDIEKIISQMTVEEKLKLLVGVGLPGMFGNKSSRVPGAAGETHQIERLKIPSTVHADGPAGLRIDPERENDSNKYHATAFPIASMLASTWNKEILFEVGKAMGNEAKEYGVDFLLAPAINIHRNPLCGRNFEYYSEDPILTGELASAFVEGVQSEGIGTSLKHFAANNQETNRMKIDTIVSERALREIYLKGFEIVVKKAKPWTVMSAYNKLNGKYCSQNKWLLTKVLREEWGFEGFVMSDWFAGDNPVEQIKAGNDLIMPGKTYNVFKDRKDEIKELKQAYEKGEITDDIINERVRTILNILMKTPSFKGYKYSNAPDFEKHARISYNAASEGVVLLKNNDVLPFSADAKVSIFGTGQIETVKGGFGSGDTHPRYTISIFEGFKEKGVKVDEKIGNFYKEKVFELRNGNYRPNYVNEFNLKIPPKLPEDILDESMIDEASETNDLAIIVISRISGEFVDRRAVKGDYYLSDDEQKLIENVSKKFHSKGKKVIVLLNIGGPIEIASWIELVDGLLLIWQPGQEAGRVVADVCLGTVNPSGKLPTTFPKDYQDIPSKSFPGKPVENPLEVVYEEDIYVGYRYYDTFQIDPLFEFGYGLSYTKFDYKNLIVKHDDENIEICFEIENSGNVEGKEIAQVYVKAPKARLDKPFQELKGFYKTKMLKPGEKEEISIKIALRDLTSFCKDKWVLEEGEYRIRVGASSRDIRLEEKVFLKEKVFNL
>NC_011653.1|WP_004103012.1|1948176_1951236_+|hypothetical-protein
MKKFDFVIENYSKQKLFSSFLPGIAGKNGIPLWVFYVNRGQCIASFGIENKANSILEFKPAGQSHTDTPLKGFRTFIKVDGRYYEPFSELTNFKREMRINKNSLEIEERNNELGLKVKVIYFVLPNEDFAALVRRVEIENEDKYEKHIEIIDGLPEVIPYGVSNGLYKEMGYTARAWMHVYNYEKKVPFYSVRTTIGDLEIVEEINNGYFYFASSGDELLEVIYDKNVLFGNSTSLQVPLVFKELGIKEVLRKEQYDENLLPSAFGVLERKLKDKVVINSMIGFSKEKGLINNNINTLKKDEYIISKKEEADLIVEELVSEIKTKTSNKLFDKYCEQNYLDNVLRGGYPLVFENKDGKVVYHIYSRKHGDLERDYNFFVLEAKKYSQGNGNFRDVAQNRRNDVIFHPEIEDFNLSMFVNLIQADGNNPLVVKGTRFKFEGDPSILDGVNEELKEFILNNYFTPGEILEKLKDKNVNEDEFVSKILYHSSQHEQAEFGEGYWIDHWTYLMDLVDTYKEIYPDKLQKTLFEKFEYKIYDSHAYVKPRKEKYKLYKGKVRQIAAVGESHEKLKIIQERGHNYLTDRNGNIYKTNMFEKLLLLAVNKFATLDPYGMGLEMEANKPGWNDALNGLPALFGSGMSETFELKRLINFMYEELKKYNKDIEVFEELQEFIQKIKVELENYFNDNDQFIYWDNVSNAKEEYRSKVFYSITGNKKKISKVELLAILKKMIKKLDEGIERAKNYGKGIYPTFFTYELVDYEVIDGVIIPKKFEVNVLPYFLEGIVRAFKVIDKDEKKKLYDFVKNSNIYDKKLKMYKTSESILNQPYSIGRIRAFTPGWLENESVFMHMEFKYLLELIKSDMLEEFYEDIKTALPPYMDYKVYGRSILENSSFIVSSANSNPNLHGQGFYARLSGSTAEFLSMWKYMFIGDKLFTLENNELTFTFEPKINKEFFENGVIEFKLFSKTKVKYVNPQLKEKIGRIEVFVDGKKFEIHGNKIKGELAHKLRNKKIDEVICYFE
>NC_011653.1|WP_004103010.1|1947263_1948154_+|aldo/keto-reductase
MRVELSRVIHGLMRIKSWKYTTEELLSLIYKLIDLGVTTFDLADIYGDYEAQEIFGRVLEKDPSLRKKIQLISKVGIVLLSNKHPNVYVKHYDTSKKHIIESVEKTLKDLRTDYIDVLLIHRPDPLMDVEEISGAFEKLKERGMVLSFGVSNFYPSQMSLFVEKLSLPLLYNQIEISLWNVDSFFNGTLDYCQEKGILPMAWSPVAGGRLFKEEDIRKDDRVLRIHNALVEVAKNHYTTPEHIAYAWLYKHPSKIYPVVGSGNFERIKTAVEALNIELDRQEWFYLLKASRGIDVL
>NC_011653.1|WP_012580492.1|1946249_1947251_+|substrate-binding-domain-containing-protein
MAGIRDVAREANVSIATVSRVINGSDKVSEETRKKVLRAMRKLNFRPKPYFGNNEVFFKTIGVLVPDIRGYHYSDIVMAIESCAFENGFDVILSIPKADIDNEKHILEKYFKRKIDGIIVAELLGGENYIEKFLKSGIPLVVLDFSVEEINFDVVNVDNMMGAYNAIKYLYENGHRKILFIPGPEWSPAANEREKGVKRFLESVDDLEIYYTNIRGYNSQDGKDAIFEYLTKNSLNFTAIFAVNDWTAIGAIDALRIKGIKVPDDVSIIGFDDAPFLDYIEPKLTTVRQPRWELGYTAAQILIERITSKRSRLPRNVVIPPELVIRESVKKIK
>NC_011653.1|WP_012580502.1|1963693_1963954_-|CRISPR-associated-endonuclease-Cas2
MFVILYYDVNVKRVSKMLKVCRKYLTWVQNSVFEGEISYSNLESLKSEIKKIVKDEDSVVIYVFNQMLYSKREVLGKDKKEETKFL
>NC_011653.1|WP_012580503.1|1963956_1964952_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MKETIYIFSSGTLKREDNSLVFITEDGQKKHIPVENLKEIFIFGEINLNKRLIEFLSKKEIMISFLNHYGFYVGSFYPREHYNSGFMILKQAQHYIDNEKRIYIAKKIVEGAAKNSLKILRYYKNRGRELDSHILEIEENIVKISKIEEIPRLMQVEGKIKKIYYESFGEIINSTDFKFTKRGKRPPIDRINALISFSNSLIYSIVLKEIYETHLDPRIGYLHSTNFRRFSLNLDIAEIFKPIIGDRTIFSVINKKIIGVKDFEKGLNRVFLSDKGKRKFIEALENRLNETVKLKKIGRNVSYRTLIRMELYKLEKHFLEDEVYEPLIMEW
>NC_011653.1|WP_012580504.1|1964957_1965434_-|CRISPR-associated-protein-Cas4
MITGSLIQAYIVCKRQAWLLSRQLIGEQDSDFLSIGRLISQESYSRDKKEITIDGGKVDIVRLENGKFKLVEVKKSSKMIKSAKFQLLYYMWKMNVDYGEIRIPKEKKVIEVRMTNEVKEKLLGLISEIEDIVNKDKVPKAERKKYCKTCSFEYFCWS
>NC_011653.1|WP_012580505.1|1965430_1967836_-|CRISPR-associated-helicase/endonuclease-Cas3
MKLFTFSKSIDDKMAHKKDEKFEPFIEHVRKTKNYLEELIEKYGIEEILKNLFYEFKISDSYIETVYEIIKYHDIGKLTEEFQNGLKLGDISITHSDIGFYTISSLLVDKVLSKKLSNKEFVFLLLIATVVSRHHSFLSDISDIIFWNEEKEKYVRYILEFLETENDKDTIINMTKSVFGNLNMKKIKKVINIEFFLLYKLLNSLLITCDYLATMEFMKGVKFVPKIIDDYLKDIILNNISSSKINGNFNPYIDKKINKFRTMKKEEVFDLNTLRSVITAKIEEKFEKSKKNVFFIEVPTGGGKTNISLRLVRKLLEKKKKVFYVIPYVNIIEQSFDYFSKFIPGEYITRYDHKYIDIADDENKEKSYTQTLFLNFPFVFTTHVGFFDMFFRKGKSDNFNFYQIANSVIILDEVQAYNPKFWNTLSNIFYYLSKYLNTTIIIMSATLPDFTKFIEKENFVENLTPDVVDHKLFERASYVFLDKDIEEKILEEVNKSKKTLVVVNTVKESYRMYENLKSKIDGEVYILNSTLLYVRKRELIDYIKKYNKEKPLVLVSTQSIEAGVDLDFDVGFRAFSLLDSIIQTMGRVNRNARLKSAKLYLFDDGNWKRIYKSDEREKILEENFSKFKSGKLKLNEFYSLTIEKLKKKLNAFTLDYLDYFKDLKFKNIDKELKLIDGDTFSLFIPLEIPLSKLNNIKKLLLEYNLISDKDKVLQGKKVWNVYMDNDFSYVENRLFSKIFSLFVVSLYNYRTEGKSIKEILKDEMNEEFYFAEDFEKYYSYKDGLNVEKFLELKSSREYDFL
>NC_011653.1|WP_012580506.1|1967813_1968587_-|CRISPR-associated-protein-Cas5
MKAFCFNIKADMGFFKKNDSNARVFTTYNFIHKPAVLGIFGAILGYSGYDRDRKNNGIEYYEKLKNFKIAIKPLYKKPLKKTVVVFNNSSGLASEETGGVLQAKEQVIVESLGYTIFVPFFETFSEAEKKIYEKLEYMVKNKYAEYPIYFGKNEFFAYFENYRSLNVEELERKEAVVDSLVKMKDVDFFGKTDEEEFDLFEEHKEEQKITLIEELPYELDENYMYVKDLFIFTDKELKIKNNEGFWRTIDDEIIYVF
>NC_011653.1|WP_012580507.1|1968599_1969505_-|type-I-CRISPR-associated-protein-Cas7
MFLKRCYGIFVLKSENSNWNADFTKYPRRLPDENATIFATDKSAKYAIRKYFVDLGERVFVWRTFKEDGQPKSLDETYKYWIEVLKDEVKMIKNNKGEEKEAIDKKDFFNKFIDVKLFGITFAVGSQQMSITGPLQISYGVNRYNVNVPYVVDIASPFRNKETDMQTTLGNEIKNLKSYYVYDFVLNPKNLPEGMEISDDEIKKLKDALKKFATNLNTTSKIGTENALLLFVTLKEGSNLVLPTMKNLVNVSEDEILDLSKISELLNKYKDEIEEVEVYYNDNICKVNGIDGSWRKGDILL
>NC_011653.1|WP_012580508.1|1969518_1971213_-|hypothetical-protein
MLKQMIDFSKRLRKENFYFQNEEPDEDIVYVIIPIDDKKSFYYVLKDKHYDKLDLLENAKKYDDIDDEFKIILKNVQLLTKKLPGDEKGNKSIGSNKGTNSYNLFIFQGVKKDLSAKIMKVYNERVLRKFKDKVEESVLKKLIFTKEEANLLFESVKEVSMKLLGKDYQNVYGKFYFVFELEDKRAYEDFYVSYLKEKVFVGENVTKKKGKCPTCGKEGIISIPDAFNTLNDKKPFLLHLGRPNGYNIMICQECALELIDFVGKFLNRFTIFPLFMNEKIQQMEIRFLKNGDKKMGFREILEQVLEEFDKEDILLDYYLLIYKDDFVYLDYVFNFKYDFNGKSIFEIEDELDNLFDKNLKSNYFNQVNVKNSLLEKNIIKYREIIFDFVYRAKYNSLSKEIIDDIFYDSLSCYLKNLYKEEKRSLKLIEIAFESYKSLNKLFGGDFVENLENIELEKLEKIENNYQYYYLIGKLTRYLLEQSKTSDKTHALVEPFINVNNSKVLLERVFELFNKYKHAIDFKNKRFDNVFSLVLNYFNSGKLPEQVSKSDKFYFFEGYFSGKNL
>NC_011653.1|WP_012580509.1|1971225_1971960_-|CRISPR-associated-endoribonuclease-Cas6
MRLKLEFISDEDIILPIGFNKYIQALIYNLFSSKLKKFVHEDGFRGKKKFSLFCFSSILERGKFFKNMKIFNFGKKISFFISSPVDMLMEDLIINLFKGDEFMLGENKIYLSSAMAVIKKVSESSIKVKAITPIEVHRTYKENGKNKTRYYTPFEKEFAELINLNIKNKWESFYKEKLDKDIEIVPLFDDERYKSVVYYGFGKKRFVIEGWKGSYLLKGDKEILSFAYDAGLGSKNSQGFGFVE
>NC_011653.1|WP_012580510.1|1972365_1972857_-|tryptophan-rich-sensory-protein
MVKKTTNCPHKISKFIASVVGVSLIGVIILFLIKKPFNTWYVYLNKPFFSPPDWMFTSVWTGIAILIGLSLFFAWEENFGRKKNLAIGIFIIQIILNISWFLVFFNLKNLLMAFFIDLILFIVLLFNTIVFYKINKTTGRLLIPYLLWVGYFTFVNLGLYVLN
>NC_011653.1|WP_012580511.1|1974853_1976107_+|extracellular-solute-binding-protein
MKKLLIFSLVLLSLFAFSAKIVFWTAPNPLQEEFWKPLIEEWNNNHLDAQIDWKTIPAAGSSEEAILTAVAAGSAPDFCTNIFSGFAVQLAEQGIIMPLDEEYGQEFFDLVKARKMENIVEGWKLNNHYYVFPIYSNPILMWWRKDKLQELGFDKPPRTYSDIYEVAKKYANPPDRYAMQVVQGRNWWDRWFDFITYYYAASSGKSYIDTKLYRATINDEYGKAVAEFIYTMFKNKWPAVEMGNQFSLSTGKALGVLQGPWSLNWAKNTYPEVYKNIWISPPPVPDNYSGGPIKTFADTKGLVVFSHTKYKKEIFEFIKWVFSNTENDVRWIEITKMPPAREDLATNPLFEKYMKDDPYFAAYAKEVGNAIPPALISNTIDVQDAMTVYLIEPLMYLKSSPEDALNKCVKEINKILY

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	MK250021	Prevotella phage Lak-B2, complete genome	447638-447669	6	0.812
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	MK250024	Prevotella phage Lak-B5, complete genome	440256-440287	6	0.812
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	MK250028	Prevotella phage Lak-B9, complete genome	444676-444707	6	0.812
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	MK250023	Prevotella phage Lak-B4, complete genome	446872-446903	6	0.812
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	MK250025	Prevotella phage Lak-B6, complete genome	443338-443369	6	0.812
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	MK250022	Prevotella phage Lak-B3, complete genome	443429-443460	6	0.812
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	MK250027	Prevotella phage Lak-B8, complete genome	447401-447432	6	0.812
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	MK250026	Prevotella phage Lak-B7, complete genome	446439-446470	6	0.812
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	MK250020	Prevotella phage Lak-B1, complete genome	444659-444690	6	0.812
NC_011653_4	4.29\|370635\|35\|NC_011653\|CRISPRCasFinder,CRT,PILER-CR	370635-370669	35	NZ_CP042531	Klebsiella aerogenes strain C9 plasmid pC9_001, complete sequence	206850-206884	7	0.8
NC_011653_9	9.4\|1183122\|36\|NC_011653\|CRT,PILER-CR,CRISPRCasFinder	1183122-1183157	36	NZ_CP033741	Enterococcus sp. FDAARGOS_553 plasmid unnamed2, complete sequence	6441-6476	7	0.806
NC_011653_12	12.11\|1960591\|37\|NC_011653\|CRISPRCasFinder,CRT,PILER-CR	1960591-1960627	37	MN270262	Streptococcus phage phi-SsuFJNP9_rum, complete genome	53054-53090	7	0.811
NC_011653_12	12.11\|1960591\|37\|NC_011653\|CRISPRCasFinder,CRT,PILER-CR	1960591-1960627	37	MN270260	Streptococcus phage phi-SsuFJNP3_rum, complete genome	53054-53090	7	0.811
NC_011653_12	12.11\|1960591\|37\|NC_011653\|CRISPRCasFinder,CRT,PILER-CR	1960591-1960627	37	MN270278	Streptococcus phage phi-SsuYZDH5_rum, complete genome	44130-44166	7	0.811
NC_011653_12	12.11\|1960591\|37\|NC_011653\|CRISPRCasFinder,CRT,PILER-CR	1960591-1960627	37	KX077896	Streptococcus phage phiJH1301-2, complete genome	3749-3785	7	0.811
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	NC_004822	Peanut witches'-broom phytoplasma plasmid pPNWB, complete sequence	862-893	8	0.75
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	NC_025193	Pigeon pea witches'-broom phytoplasma plasmid pPPWB-Hn, complete sequence	862-893	8	0.75
NC_011653_12	12.11\|1960591\|37\|NC_011653\|CRISPRCasFinder,CRT,PILER-CR	1960591-1960627	37	MN693456	Marine virus AFVG_25M411, complete genome	4731-4767	8	0.784
NC_011653_3	3.25\|328598\|35\|NC_011653\|CRISPRCasFinder,CRT,PILER-CR	328598-328632	35	NZ_CP024788	Nostoc flagelliforme CCNUN1 plasmid pNFSY03, complete sequence	14961-14995	9	0.743
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	MN693685	Marine virus AFVG_250M1024, complete genome	31566-31597	9	0.719
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	MN693729	Marine virus AFVG_250M1023, complete genome	5535-5566	9	0.719
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	NZ_CP013615	Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence	292775-292806	9	0.719
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	KU594605	Cyanophage S-RIM50 isolate RW_29_0704, complete genome	82470-82501	9	0.719
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	MH107246	Synechococcus phage S-B64, complete genome	59946-59977	9	0.719
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	KF114878	Leptospira phage LkmZ_Bejolso9, complete genome	37177-37208	9	0.719
NC_011653_4	4.1\|368642\|32\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	368642-368673	32	KY945241	Synechococcus phage S-H35, complete genome	115167-115198	9	0.719
NC_011653_4	4.32\|370842\|34\|NC_011653\|CRISPRCasFinder,CRT,PILER-CR	370842-370875	34	MN694485	Marine virus AFVG_250M19, complete genome	28914-28947	9	0.735
NC_011653_11	11.5\|1332587\|36\|NC_011653\|CRISPRCasFinder,CRT,PILER-CR	1332587-1332622	36	AP013755	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C27-MedDCM-OCT-S26-C265, * SEQUENCING IN PROGRESS *	4153-4188	9	0.75
NC_011653_3	3.17\|328030\|35\|NC_011653\|PILER-CR,CRISPRCasFinder,CRT	328030-328064	35	NZ_CP034862	Buchnera aphidicola (Muscaphis stroyani) strain Mst plasmid pLeu, complete sequence	7241-7275	10	0.714
NC_011653_6	6.17\|753296\|38\|NC_011653\|CRISPRCasFinder,CRT,PILER-CR	753296-753333	38	NZ_CP017947	Bosea sp. Tri-49 plasmid unnamed1, complete sequence	431878-431915	10	0.737
NC_011653_9	9.4\|1183122\|36\|NC_011653\|CRT,PILER-CR,CRISPRCasFinder	1183122-1183157	36	NZ_CP032268	Acinetobacter sp. WCHAc010034 plasmid p1_010034, complete sequence	9031-9066	10	0.722
NC_011653_12	12.52\|1963319\|35\|NC_011653\|CRISPRCasFinder,CRT,PILER-CR	1963319-1963353	35	NZ_CP018080	Sulfitobacter sp. AM1-D1 plasmid unnamed4, complete sequence	133549-133583	10	0.714
NC_011653_11	11.10\|1332925\|34\|NC_011653\|CRISPRCasFinder,CRT,PILER-CR	1332925-1332958	34	NZ_CP034149	Pantoea agglomerans strain L15 plasmid pPagL15_1, complete sequence	368739-368772	11	0.676

1. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to MK250021 (Prevotella phage Lak-B2, complete genome) position: , mismatch: 6, identity: 0.812

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
ctaagttcatcatcaatataaactttctatga	Protospacer
 .*** ************* ******** *.*

2. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to MK250024 (Prevotella phage Lak-B5, complete genome) position: , mismatch: 6, identity: 0.812

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
ctaagttcatcatcaatataaactttctatga	Protospacer
 .*** ************* ******** *.*

3. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to MK250028 (Prevotella phage Lak-B9, complete genome) position: , mismatch: 6, identity: 0.812

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
ctaagttcatcatcaatataaactttctatga	Protospacer
 .*** ************* ******** *.*

4. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to MK250023 (Prevotella phage Lak-B4, complete genome) position: , mismatch: 6, identity: 0.812

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
ctaagttcatcatcaatataaactttctatga	Protospacer
 .*** ************* ******** *.*

5. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to MK250025 (Prevotella phage Lak-B6, complete genome) position: , mismatch: 6, identity: 0.812

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
ctaagttcatcatcaatataaactttctatga	Protospacer
 .*** ************* ******** *.*

6. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to MK250022 (Prevotella phage Lak-B3, complete genome) position: , mismatch: 6, identity: 0.812

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
ctaagttcatcatcaatataaactttctatga	Protospacer
 .*** ************* ******** *.*

7. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to MK250027 (Prevotella phage Lak-B8, complete genome) position: , mismatch: 6, identity: 0.812

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
ctaagttcatcatcaatataaactttctatga	Protospacer
 .*** ************* ******** *.*

8. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to MK250026 (Prevotella phage Lak-B7, complete genome) position: , mismatch: 6, identity: 0.812

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
ctaagttcatcatcaatataaactttctatga	Protospacer
 .*** ************* ******** *.*

9. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to MK250020 (Prevotella phage Lak-B1, complete genome) position: , mismatch: 6, identity: 0.812

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
ctaagttcatcatcaatataaactttctatga	Protospacer
 .*** ************* ******** *.*

10. spacer 4.29|370635|35|NC_011653|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP042531 (Klebsiella aerogenes strain C9 plasmid pC9_001, complete sequence) position: , mismatch: 7, identity: 0.8

tttttgttccatccttatgtaaaat-ttcatacttc	CRISPR spacer
tttttgttccatccttcggtaaaatatgtgttctt-	Protospacer
****************  ******* * ..* ***

11. spacer 9.4|1183122|36|NC_011653|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP033741 (Enterococcus sp. FDAARGOS_553 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.806

gcaatttt-actacttattctaattttaaaaacaaag	CRISPR spacer
-taattttgagtacttattctaattttaaaaaatcaa	Protospacer
 .****** * *********************   *.

12. spacer 12.11|1960591|37|NC_011653|CRISPRCasFinder,CRT,PILER-CR matches to MN270262 (Streptococcus phage phi-SsuFJNP9_rum, complete genome) position: , mismatch: 7, identity: 0.811

tattataacctttttcttttgctatttcaatatattt	CRISPR spacer
ttttcgaatatttttcttttgctaattcaatattttt	Protospacer
* **  **. ************** ******** ***

13. spacer 12.11|1960591|37|NC_011653|CRISPRCasFinder,CRT,PILER-CR matches to MN270260 (Streptococcus phage phi-SsuFJNP3_rum, complete genome) position: , mismatch: 7, identity: 0.811

tattataacctttttcttttgctatttcaatatattt	CRISPR spacer
ttttcgaatatttttcttttgctaattcaatattttt	Protospacer
* **  **. ************** ******** ***

14. spacer 12.11|1960591|37|NC_011653|CRISPRCasFinder,CRT,PILER-CR matches to MN270278 (Streptococcus phage phi-SsuYZDH5_rum, complete genome) position: , mismatch: 7, identity: 0.811

tattataacctttttcttttgctatttcaatatattt	CRISPR spacer
ttttcgaatatttttcttttgctaattcaatattttt	Protospacer
* **  **. ************** ******** ***

15. spacer 12.11|1960591|37|NC_011653|CRISPRCasFinder,CRT,PILER-CR matches to KX077896 (Streptococcus phage phiJH1301-2, complete genome) position: , mismatch: 7, identity: 0.811

tattataacctttttcttttgctatttcaatatattt	CRISPR spacer
ttttcgaatatttttcttttgctaattcaatattttt	Protospacer
* **  **. ************** ******** ***

16. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to NC_004822 (Peanut witches'-broom phytoplasma plasmid pPNWB, complete sequence) position: , mismatch: 8, identity: 0.75

acaagatcatcatcaatatcaacttt--ctttaa	CRISPR spacer
tgaaaatcatcataaatatcaacttcggcatt--	Protospacer
  **.******** ***********.  * **

17. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to NC_025193 (Pigeon pea witches'-broom phytoplasma plasmid pPPWB-Hn, complete sequence) position: , mismatch: 8, identity: 0.75

acaagatcatcatcaatatcaacttt--ctttaa	CRISPR spacer
tgaaaatcatcataaatatcaacttcggcatt--	Protospacer
  **.******** ***********.  * **

18. spacer 12.11|1960591|37|NC_011653|CRISPRCasFinder,CRT,PILER-CR matches to MN693456 (Marine virus AFVG_25M411, complete genome) position: , mismatch: 8, identity: 0.784

tattataacctttttcttttgctatttcaatatattt	CRISPR spacer
cattaaaacctttttcttttgctatgtcatttaagtc	Protospacer
.**** ******************* *** *  * *.

19. spacer 3.25|328598|35|NC_011653|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP024788 (Nostoc flagelliforme CCNUN1 plasmid pNFSY03, complete sequence) position: , mismatch: 9, identity: 0.743

ggaaactatagaagaaaagtttgtggttataaaac	CRISPR spacer
ggatactatagaagaaaagattgtgcaattgcatc	Protospacer
*** *************** *****    *. * *

20. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to MN693685 (Marine virus AFVG_250M1024, complete genome) position: , mismatch: 9, identity: 0.719

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
gtaccatcatcatccatatcaacttccttgcc	Protospacer
..*  ********* **********.***

21. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to MN693729 (Marine virus AFVG_250M1023, complete genome) position: , mismatch: 9, identity: 0.719

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
gtaccatcatcatccatatcaacttccttgcc	Protospacer
..*  ********* **********.***

22. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013615 (Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence) position: , mismatch: 9, identity: 0.719

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
tatacctattcatcaatatcacctttttttaa	Protospacer
   *  *  ************ ****.*****

23. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to KU594605 (Cyanophage S-RIM50 isolate RW_29_0704, complete genome) position: , mismatch: 9, identity: 0.719

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
ggagtaacatcatcaatatcaacgtactttgt	Protospacer
. *. * **************** * ****.

24. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to MH107246 (Synechococcus phage S-B64, complete genome) position: , mismatch: 9, identity: 0.719

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
tcaagatcatcatcaagatcatctgctagtag	Protospacer
 *************** **** ** ..  **.

25. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to KF114878 (Leptospira phage LkmZ_Bejolso9, complete genome) position: , mismatch: 9, identity: 0.719

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
cgaagatcaccatcaatatcaccttgtaatac	Protospacer
  *******.*********** *** .  **

26. spacer 4.1|368642|32|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to KY945241 (Synechococcus phage S-H35, complete genome) position: , mismatch: 9, identity: 0.719

acaagatcatcatcaatatcaactttctttaa	CRISPR spacer
tcaagatcatcatcaagatcatctgctagtag	Protospacer
 *************** **** ** ..  **.

27. spacer 4.32|370842|34|NC_011653|CRISPRCasFinder,CRT,PILER-CR matches to MN694485 (Marine virus AFVG_250M19, complete genome) position: , mismatch: 9, identity: 0.735

agtcttgcatggcttttcgcaattgttctacgac----	CRISPR spacer
cttcttgcatggcttttctcatttgtt----gataatt	Protospacer
  **************** ** *****    **.

28. spacer 11.5|1332587|36|NC_011653|CRISPRCasFinder,CRT,PILER-CR matches to AP013755 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C27-MedDCM-OCT-S26-C265, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.75

aacatgatggcatattactcaaaagagttacaggtg	CRISPR spacer
acagagaaaacatactactcaaaagagttagaggtg	Protospacer
*  . ** ..****.*************** *****

29. spacer 3.17|328030|35|NC_011653|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034862 (Buchnera aphidicola (Muscaphis stroyani) strain Mst plasmid pLeu, complete sequence) position: , mismatch: 10, identity: 0.714

gaaatatgcagaaattgagaaagtagattggaaac	CRISPR spacer
tttatttccagaaattgagaaagtagataatccac	Protospacer
   ** * ******************** .   **

30. spacer 6.17|753296|38|NC_011653|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017947 (Bosea sp. Tri-49 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.737

aataatcgcagatgacgacgatgaggaagacaacgatg	CRISPR spacer
gcatgttcctgatgacatcgatgaggaagacaacgatg	Protospacer
.   .*. * ******. ********************

31. spacer 9.4|1183122|36|NC_011653|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP032268 (Acinetobacter sp. WCHAc010034 plasmid p1_010034, complete sequence) position: , mismatch: 10, identity: 0.722

gcaattttactacttattctaattttaaaaacaaag	CRISPR spacer
tttattttactacttatttttattttaaatccttat	Protospacer
 . ***************.* ********  *  *

32. spacer 12.52|1963319|35|NC_011653|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP018080 (Sulfitobacter sp. AM1-D1 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.714

cggtaatcaggcgttgctgtttctgtgtaataccc	CRISPR spacer
cttccatcaggcgttgctgttcctgtgcaagcgcg	Protospacer
*  . ****************.*****.**   *

33. spacer 11.10|1332925|34|NC_011653|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP034149 (Pantoea agglomerans strain L15 plasmid pPagL15_1, complete sequence) position: , mismatch: 11, identity: 0.676

aaaaaggagttaataagaacaaggctcggcattg	CRISPR spacer
ggaaaggagttaataagaaaaatgcttaccccac	Protospacer
..***************** ** ***.. * .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

391624 : 402833

Tupanvirus(25.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012579540.1\|391624_392482_-	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.5e-23	27.9
WP_012579541.1\|392482_393475_-	ABC transporter permease	NA	NA	NA	NA
WP_004104112.1\|393487_394036_-	macro domain-containing protein	A3EXF6	Bat_coronavirus	9.2e-14	40.6
WP_004104115.1\|394019_395252_-	replication-associated recombination protein A	G3MBE0	Bacillus_virus	1.2e-66	39.3
WP_004104117.1\|395220_396153_-	SDR family NAD(P)-dependent oxidoreductase	A0A1V0SAI6	Catovirus	1.4e-41	32.9
WP_004104119.1\|396153_396657_-	metal-dependent transcriptional regulator	NA	NA	NA	NA
WP_004104121.1\|396649_397249_-	uracil-DNA glycosylase	S5M974	Bacillus_phage	3.3e-25	38.9
WP_012579543.1\|397436_400082_+	pyruvate, phosphate dikinase	H8YJB7	Vibrio_phage	1.0e-94	41.3
WP_012579544.1\|400139_400550_+	hypothetical protein	NA	NA	NA	NA
WP_012579545.1\|400546_401902_+	bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU	A0A2K9L821	Tupanvirus	4.6e-30	36.1
WP_012579546.1\|401882_402833_+	ribose-phosphate pyrophosphokinase	A0A2K9L2G2	Tupanvirus	8.4e-47	36.7

DBSCAN-SWA_2

589840 : 651506

Bacillus_phage(22.22%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012580544.1\|589840_590302_+\|transposase	IS200/IS605 family transposase	A0A286QN76	Streptococcus_phage	1.7e-45	63.9
WP_041427179.1\|590240_591449_+\|transposase	transposase	A0A0H3UZC2	Geobacillus_virus	5.8e-77	46.0
WP_012579661.1\|591700_592603_+	hypothetical protein	NA	NA	NA	NA
WP_012579662.1\|592599_593133_+	VanZ family protein	NA	NA	NA	NA
WP_012579663.1\|593200_594070_+	bifunctional riboflavin kinase/FAD synthetase	NA	NA	NA	NA
WP_012579664.1\|594059_594671_+	endonuclease III	NA	NA	NA	NA
WP_012579665.1\|594667_595810_+	DegT/DnrJ/EryC1/StrS family aminotransferase	E5ES42	Bathycoccus_sp._RCC1105_virus	2.5e-45	34.1
WP_004100515.1\|595811_596006_+	hypothetical protein	NA	NA	NA	NA
WP_012579666.1\|596046_597387_+	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	1.3e-53	34.6
WP_012579667.1\|597454_598267_-	DUF4382 domain-containing protein	NA	NA	NA	NA
WP_012580542.1\|598421_599552_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	2.5e-42	41.1
WP_012579668.1\|599661_602901_-	O-antigen ligase family protein	NA	NA	NA	NA
WP_012580546.1\|603066_604326_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_012579669.1\|604740_605265_+	ATP-dependent DNA helicase	NA	NA	NA	NA
WP_012579670.1\|605404_606568_-	ATPase	NA	NA	NA	NA
WP_004104379.1\|608738_608999_+	hypothetical protein	NA	NA	NA	NA
WP_041427181.1\|608931_609552_+	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_041427182.1\|609595_611002_-	ATP-binding protein	NA	NA	NA	NA
WP_012579675.1\|612867_614037_+	ATP-binding protein	NA	NA	NA	NA
WP_012579676.1\|614416_614698_+	hypothetical protein	NA	NA	NA	NA
WP_012579677.1\|614982_616365_-	ATP-binding protein	NA	NA	NA	NA
WP_004104389.1\|616629_616968_-	hypothetical protein	NA	NA	NA	NA
WP_004104390.1\|617096_617249_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_004104402.1\|617435_617573_+	hypothetical protein	NA	NA	NA	NA
WP_004104404.1\|617730_619113_-	AAA family ATPase	NA	NA	NA	NA
WP_148203241.1\|619293_619593_-	MFS transporter	NA	NA	NA	NA
WP_012579679.1\|619632_620136_+	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_012579680.1\|620188_621874_-	carbon starvation protein A	NA	NA	NA	NA
WP_012579681.1\|622012_622696_-	response regulator transcription factor	NA	NA	NA	NA
WP_012579682.1\|622692_624357_-	histidine kinase	Q9EYF3	Enterobacteria_phage	1.8e-57	28.1
WP_004104412.1\|624350_624554_-	hypothetical protein	NA	NA	NA	NA
WP_012579683.1\|624762_625596_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_012579684.1\|625606_626473_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_012579685.1\|626544_627858_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_012579686.1\|628193_632108_+	alpha-2-macroglobulin	NA	NA	NA	NA
WP_100217346.1\|632148_632514_+	hypothetical protein	NA	NA	NA	NA
WP_148203266.1\|632461_633088_+	DUF1175 family protein	NA	NA	NA	NA
WP_012579689.1\|633115_635056_-	S9 family peptidase	NA	NA	NA	NA
WP_114702919.1\|635164_635266_-	MetS family NSS transporter small subunit	NA	NA	NA	NA
WP_012579690.1\|635268_636786_-	sodium-dependent transporter	NA	NA	NA	NA
WP_012579691.1\|636928_638380_-	GGDEF domain-containing protein	NA	NA	NA	NA
WP_004104442.1\|638476_638965_-	dihydrofolate reductase	A0A2I6UHX1	Bacillus_phage	1.9e-15	40.2
WP_012579692.1\|639044_639509_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_158301508.1\|639597_640575_+	diguanylate cyclase	G3MA91	Bacillus_virus	3.2e-17	33.7
WP_004104445.1\|641080_641779_-	50S ribosomal protein L1	NA	NA	NA	NA
WP_004104446.1\|641804_642230_-	50S ribosomal protein L11	NA	NA	NA	NA
WP_004104462.1\|642287_643352_-	KOW motif-containing protein	NA	NA	NA	NA
WP_012579694.1\|643369_643558_-	preprotein translocase subunit SecE	NA	NA	NA	NA
WP_041427184.1\|643665_643815_-	50S ribosomal protein L33	NA	NA	NA	NA
WP_012579695.1\|644051_644276_-	30S ribosomal protein S18	NA	NA	NA	NA
WP_004104465.1\|644300_644705_-	single-stranded DNA-binding protein	A0A139ZPD1	Marinitoga_camini_virus	5.3e-27	48.9
WP_004104467.1\|644701_645061_-	30S ribosomal protein S6	NA	NA	NA	NA
WP_012579697.1\|645421_646489_+	rod shape-determining protein RodA	NA	NA	NA	NA
WP_004104479.1\|646485_647121_+	hypothetical protein	NA	NA	NA	NA
WP_004104481.1\|647136_647988_+\|tRNA	glycine--tRNA ligase subunit alpha	NA	NA	NA	NA
WP_012579699.1\|650006_650513_+	rubrerythrin family protein	NA	NA	NA	NA
WP_004104484.1\|650576_651506_+\|protease	FtsH protease activity modulator HflK	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_011653

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection