CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Prophage number
NC_011758	Methylorubrum extorquens CM4 plasmid pCMU01, complete sequence	0 crisprs	cas3,WYL	3
NC_011760	Methylorubrum extorquens CM4 plasmid pCMU02, complete sequence	0 crisprs	NA	0
NC_011757	Methylorubrum extorquens CM4, complete sequence	2 crisprs	csa3,DEDDh,WYL,cas3	6

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

62545 : 79760

uncultured_virus(25.0%)

transposase,integrase

attL 50471:50488|attR 78196:78213

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
50471:50488	attL	NA	NA	NA	NA
WP_012606094.1\|62545_63961_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012606095.1\|64859_66080_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	5.9e-37	40.9
WP_012606097.1\|67085_68285_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.8e-94	47.5
WP_012606098.1\|69468_71268_-	methanol/ethanol family PQQ-dependent dehydrogenase	NA	NA	NA	NA
WP_012606099.1\|71458_72895_+	HAMP domain-containing protein	NA	NA	NA	NA
WP_012606100.1\|72891_73548_+	response regulator transcription factor	NA	NA	NA	NA
WP_012606101.1\|73837_74671_-\|transposase	IS481 family transposase	NA	NA	NA	NA
WP_085985917.1\|74748_75920_-\|transposase	IS3-like element ISMch1 family transposase	S5WIU1	Leptospira_phage	1.2e-13	27.5
WP_076611538.1\|76969_78321_-\|transposase	IS3-like element ISMch3 family transposase	Q6J1X2	Lactobacillus_phage	2.8e-11	27.5
78196:78213	attR	NA	NA	NA	NA
WP_012606106.1\|78680_79760_+\|transposase	IS110-like element ISMch6 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

100232 : 166494

Leptospira_phage(18.18%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012606126.1\|100232_101292_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_012606127.1\|101485_105400_+	AAA family ATPase	NA	NA	NA	NA
WP_085985918.1\|106970_108141_+\|transposase	IS3-like element ISMch1 family transposase	S5WIU1	Leptospira_phage	5.7e-13	28.4
WP_012606131.1\|108476_109943_-	DUF4263 domain-containing protein	NA	NA	NA	NA
WP_012606132.1\|110277_112821_-	S8 family peptidase	NA	NA	NA	NA
WP_012606133.1\|112873_113884_-	AAA family ATPase	R4TQL5	Phaeocystis_globosa_virus	1.1e-15	30.0
WP_158020185.1\|115158_115701_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_012606134.1\|116384_118322_-	squalene--hopene cyclase	NA	NA	NA	NA
WP_012606135.1\|118427_118961_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_012606136.1\|119116_119461_+	multidrug efflux SMR transporter	NA	NA	NA	NA
WP_012606138.1\|120080_121235_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_012606139.1\|121254_124416_+	multidrug efflux RND transporter permease subunit	NA	NA	NA	NA
WP_012606140.1\|125325_127356_-	cache domain-containing protein	A0A1B0VMK3	Pseudomonas_phage	9.6e-08	29.2
WP_012606141.1\|127343_128714_-	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_193373788.1\|128843_130499_-	OFA family MFS transporter	NA	NA	NA	NA
WP_012606143.1\|130966_133162_+	TonB-dependent receptor	NA	NA	NA	NA
WP_085985919.1\|133326_134092_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_017487497.1\|134105_134600_+	hypothetical protein	NA	NA	NA	NA
WP_076611538.1\|135542_136894_-\|transposase	IS3-like element ISMch3 family transposase	Q6J1X2	Lactobacillus_phage	2.8e-11	27.5
WP_158020186.1\|137285_137627_+	hypothetical protein	NA	NA	NA	NA
WP_012606148.1\|137679_138192_-	DUF2478 domain-containing protein	NA	NA	NA	NA
WP_012606149.1\|138596_139586_-	hypothetical protein	NA	NA	NA	NA
WP_012455564.1\|139687_140941_-	DUF2325 domain-containing protein	NA	NA	NA	NA
WP_012455565.1\|141033_141378_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_049832754.1\|141473_142724_-	molybdopterin molybdotransferase MoeA	NA	NA	NA	NA
WP_012606151.1\|142861_143917_+	NAD(P)-dependent alcohol dehydrogenase	A0A2K9L339	Tupanvirus	1.7e-80	45.2
WP_012606152.1\|143953_144751_+	molybdate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_012606153.1\|144747_145440_+	molybdate ABC transporter permease subunit	NA	NA	NA	NA
WP_012606154.1\|145467_146544_+	molybdenum ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.9e-16	32.8
WP_012606155.1\|146703_146913_+	TOBE domain-containing protein	NA	NA	NA	NA
WP_012606156.1\|147417_148011_+	recombinase family protein	Q1MVP4	Enterobacteria_phage	4.1e-28	42.3
WP_158020187.1\|148124_148997_-	transporter	NA	NA	NA	NA
WP_012606158.1\|149202_149712_-	acetone carboxylase subunit gamma	NA	NA	NA	NA
WP_012606159.1\|149800_152131_-	hydantoinase B/oxoprolinase family protein	NA	NA	NA	NA
WP_012606160.1\|152168_154322_-	hydantoinase/oxoprolinase family protein	NA	NA	NA	NA
WP_012606161.1\|154557_156480_-	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_080515619.1\|156830_157451_-	PAS domain-containing protein	NA	NA	NA	NA
WP_085985478.1\|157558_158658_-\|transposase	IS3-like element ISMex11 family transposase	S5WIU1	Leptospira_phage	4.1e-53	43.2
WP_012606162.1\|158723_159278_+	GGDEF domain-containing protein	A0A127AWB9	Bacillus_phage	1.4e-14	35.8
WP_012606163.1\|159274_159697_-	hypothetical protein	G1DAN9	Mycobacterium_virus	1.6e-10	36.9
WP_012606164.1\|159974_160145_+	hypothetical protein	NA	NA	NA	NA
WP_041929427.1\|160368_160872_+	MucR family transcriptional regulator	A0A1P8VVG0	Erythrobacter_phage	3.1e-16	38.2
WP_012606166.1\|161422_161740_+	DUF736 domain-containing protein	NA	NA	NA	NA
WP_012606167.1\|161809_162067_+	hypothetical protein	NA	NA	NA	NA
WP_012606168.1\|162216_162936_-	WYL domain-containing protein	NA	NA	NA	NA
WP_012606169.1\|163022_163418_+	RidA family protein	NA	NA	NA	NA
WP_080515626.1\|163530_163923_-	DUF3291 domain-containing protein	NA	NA	NA	NA
WP_158020188.1\|164033_164183_-	hypothetical protein	NA	NA	NA	NA
WP_012606173.1\|165414_166494_+\|transposase	IS110-like element ISMch6 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

206018 : 290303

Mycobacterium_phage(15.0%)

transposase,integrase

attL 244369:244386|attR 278293:278310

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012606213.1\|206018_206824_-\|transposase	IS5-like element ISMch2 family transposase	A0A0M5M147	Mycobacterium_phage	1.6e-22	33.7
WP_012606214.1\|207107_208283_-	glutathione-dependent formaldehyde dehydrogenase	E3SJ82	Synechococcus_phage	7.2e-08	25.7
WP_080515621.1\|210404_210803_+	recombinase family protein	E5FFF9	Burkholderia_phage	1.3e-30	52.3
WP_012606215.1\|210799_211429_+	histidine phosphatase family protein	NA	NA	NA	NA
WP_012606216.1\|213467_214121_+	ParA family protein	A0A0M3ULE3	Mycobacterium_phage	3.9e-11	32.4
WP_012606217.1\|214120_214453_+	hypothetical protein	NA	NA	NA	NA
WP_012606213.1\|214585_215391_-\|transposase	IS5-like element ISMch2 family transposase	A0A0M5M147	Mycobacterium_phage	1.6e-22	33.7
WP_158020209.1\|215440_215851_-	hypothetical protein	NA	NA	NA	NA
WP_012606219.1\|215853_218841_-	hypothetical protein	NA	NA	NA	NA
WP_012606220.1\|218837_219308_-	hypothetical protein	NA	NA	NA	NA
WP_012606221.1\|219319_219574_-	hypothetical protein	NA	NA	NA	NA
WP_012606222.1\|219570_220854_-	DotG/IcmE/VirB10 family protein	NA	NA	NA	NA
WP_012606223.1\|220865_222053_-	type IV secretion system protein IcmK	NA	NA	NA	NA
WP_012606224.1\|222049_222706_-	DotI/IcmL/TraM family protein	NA	NA	NA	NA
WP_012606225.1\|222702_222978_-	hypothetical protein	NA	NA	NA	NA
WP_193373785.1\|222979_223489_-	hypothetical protein	NA	NA	NA	NA
WP_158020191.1\|224032_224329_+	hypothetical protein	NA	NA	NA	NA
WP_158020210.1\|224412_224904_+	hypothetical protein	NA	NA	NA	NA
WP_158020192.1\|224920_225451_-	hypothetical protein	NA	NA	NA	NA
WP_012606229.1\|225685_226840_+	type IV secretory system conjugative DNA transfer family protein	NA	NA	NA	NA
WP_012606230.1\|226843_228025_+	Flp pilus assembly complex ATPase component TadA	NA	NA	NA	NA
WP_041929436.1\|227993_228644_+	DUF882 domain-containing protein	A0A1X9Q111	Human_gut_gokushovirus	8.3e-06	34.3
WP_012606232.1\|228640_228886_+	hypothetical protein	NA	NA	NA	NA
WP_012606233.1\|228870_229548_+	hypothetical protein	NA	NA	NA	NA
WP_012606234.1\|229544_229943_+	hypothetical protein	NA	NA	NA	NA
WP_012606235.1\|229939_230890_+	M23 family metallopeptidase	NA	NA	NA	NA
WP_012606236.1\|230886_231651_+	hypothetical protein	NA	NA	NA	NA
WP_012606237.1\|231647_232670_+	hypothetical protein	NA	NA	NA	NA
WP_012606238.1\|232666_233653_+	hypothetical protein	NA	NA	NA	NA
WP_012606239.1\|233661_235920_+	DotA/TraY family protein	NA	NA	NA	NA
WP_012606240.1\|235923_237246_+	hypothetical protein	NA	NA	NA	NA
WP_158020193.1\|237959_239216_+	plasmid partitioning protein RepA	A0A240F4U1	Ochrobactrum_phage	1.2e-96	49.7
WP_158020194.1\|239368_240217_+	plasmid partitioning protein RepB	A0A240F4U0	Ochrobactrum_phage	6.3e-38	35.7
WP_012606244.1\|240421_241633_+	replication initiation protein RepC	L7TKN6	Rhizobium_phage	6.7e-25	30.3
WP_012778769.1\|242519_242882_+	hypothetical protein	NA	NA	NA	NA
WP_012606126.1\|243535_244595_+\|transposase	IS630 family transposase	NA	NA	NA	NA
244369:244386	attL	NA	NA	NA	NA
WP_080515622.1\|244702_244954_-	SDR family oxidoreductase	A0A0M4JSW6	Mollivirus	2.5e-06	47.3
WP_193373789.1\|245164_246649_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_012606246.1\|246645_247470_+	ATP-binding protein	A0A059NT77	Lactococcus_phage	1.8e-29	33.9
WP_012606247.1\|247665_248919_+\|transposase	IS701-like element ISMch7 family transposase	NA	NA	NA	NA
WP_085985920.1\|249081_249847_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_012606249.1\|249896_250493_+	recombinase family protein	Q1MVP4	Enterobacteria_phage	6.7e-26	40.3
WP_012606250.1\|250576_250867_+	BrnT family toxin	NA	NA	NA	NA
WP_012606251.1\|250850_251105_+	hypothetical protein	NA	NA	NA	NA
WP_012606252.1\|252844_253649_+\|transposase	IS5-like element ISMch9 family transposase	NA	NA	NA	NA
WP_012606253.1\|253764_254808_-	phospholipase D family protein	NA	NA	NA	NA
WP_012606254.1\|254816_257630_-	class I SAM-dependent DNA methyltransferase	Q6NE04	Leptospira_phage	4.0e-222	43.2
WP_012606255.1\|257809_258550_-	hypothetical protein	NA	NA	NA	NA
WP_085985411.1\|258608_259366_-\|transposase	IS5-like element ISMpo7 family transposase	A0A0N9SJT9	Paenibacillus_phage	1.2e-08	35.0
WP_158020211.1\|259398_259638_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_041929389.1\|259641_259833_+	hypothetical protein	NA	NA	NA	NA
WP_003607500.1\|259869_261075_+	PD40 domain-containing protein	NA	NA	NA	NA
WP_012606256.1\|261915_263193_+\|transposase	IS110-like element ISMex12 family transposase	A0A1S7J231	Thermus_phage	2.6e-11	35.4
WP_085985917.1\|263325_264496_+\|transposase	IS3-like element ISMch1 family transposase	S5WIU1	Leptospira_phage	1.2e-13	27.5
WP_111772158.1\|264706_265099_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_158020196.1\|265088_265328_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_012606259.1\|265576_266638_+\|integrase	tyrosine-type recombinase/integrase	Q5QBN6	Enterobacteria_phage	1.7e-19	28.6
WP_049832756.1\|267082_268051_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_012606261.1\|268466_270011_+	transcriptional regulator	NA	NA	NA	NA
WP_012606262.1\|270014_270800_+	hypothetical protein	NA	NA	NA	NA
WP_012606263.1\|270810_271713_+	nucleotide-binding protein	NA	NA	NA	NA
WP_012606264.1\|272001_273888_+	S8 family peptidase	A0A217EQY2	Bacillus_phage	1.2e-12	29.2
WP_012606265.1\|273900_275142_+	hypothetical protein	NA	NA	NA	NA
WP_041929391.1\|275554_275764_-	hypothetical protein	NA	NA	NA	NA
WP_012606266.1\|276004_277591_+	hypothetical protein	NA	NA	NA	NA
WP_142582431.1\|277689_279204_+\|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	7.9e-124	47.2
278293:278310	attR	NA	NA	NA	NA
WP_012606268.1\|279215_279959_+	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	3.7e-58	47.5
WP_041929392.1\|280024_280222_-	hypothetical protein	NA	NA	NA	NA
WP_012606269.1\|280708_282358_+	hypothetical protein	NA	NA	NA	NA
WP_012606270.1\|282360_284340_+	hypothetical protein	NA	NA	NA	NA
WP_158020197.1\|284336_285119_+	hypothetical protein	NA	NA	NA	NA
WP_012606272.1\|285216_289176_-	SIR2 family protein	NA	NA	NA	NA
WP_012606273.1\|289205_290303_+\|transposase	IS5-like element ISMch8 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_011757

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_011757_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011757_1

2287763-2288007

Orphan

Consensus_repeat	Method
ACCCGGACAACGACGGCACCCTCGAC	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_011757_1

>merge|NC_011757|1|2287763-2288007|CRISPRCasFinder
ATCCGGACAAGGACGGCACGATCGATCTCAAGGAGGCCCTGGCCGCCGGCTCCGCTGCCTTCGACAAGCTCGATCCGGATAAGGACGGTACGCTCGATGCCAAAGAGCTGAAGGGCCGCGTCAGCGAGGCTGACCTCAAGAAGCTCGACCCGGACAACGACGGCACCCTCGACAAGAAGGAATACCTTGCCGCCGTCGAGGCGCAGTTCAAGGCCGCTAACCCGGACAACGACGGCACCATCGAC

>NC_011757|1|1|2287763-2288007|CRISPRCasFinder
ATCCGGACAAGGACGGCACGATCGAT	CTCAAGGAGGCCCTGGCCGCCGGCTCCGCTGCCTTCGACAAGCTCG
ATCCGGATAAGGACGGTACGCTCGAT	GCCAAAGAGCTGAAGGGCCGCGTCAGCGAGGCTGACCTCAAGAAGCTCG
ACCCGGACAACGACGGCACCCTCGAC	AAGAAGGAATACCTTGCCGCCGTCGAGGCGCAGTTCAAGGCCGCTA
ACCCGGACAACGACGGCACCATCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_011757.1\|WP_015950712.1\|2281278_2281713_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|259872
NC_011757.1\|WP_003607156.1\|2298689_2298950_-\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|379323
NC_011757.1\|WP_015950719.1\|2292646_2295061_+\|LPS-biosynthesis-protein	unknown	unknown	gnl\|CDD\|225747
NC_011757.1\|WP_015950710.1\|2278764_2280033_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|274821
NC_011757.1\|WP_015950722.1\|2299099_2300638_+\|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl\|CDD\|223679
NC_011757.1\|WP_012253408.1\|2295615_2295939_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NC_011757.1\|WP_015950715.1\|2283650_2284280_+\|hypothetical-protein	unknown	unknown	unknown
NC_011757.1\|WP_015950721.1\|2298166_2298655_+\|hypothetical-protein	unknown	unknown	unknown
NC_011757.1\|WP_003601795.1\|2288263_2288623_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234609
NC_011757.1\|WP_003601804.1\|2282000_2282750_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|274822
NC_011757.1\|WP_015950717.1\|2288726_2290283_-\|undecaprenyl-phosphate-glucose-phosphotransferase	unknown	unknown	gnl\|CDD\|274396
NC_011757.1\|WP_015950720.1\|2296029_2297910_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|236382
NC_011757.1\|WP_015950711.1\|2280199_2281186_+\|YVTN-family-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|274824
NC_011757.1\|WP_015950714.1\|2282746_2283640_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|163573
NC_011757.1\|WP_015950713.1\|2281725_2282004_+\|hypothetical-protein	unknown	unknown	unknown
NC_011757.1\|WP_003601790.1\|2291846_2292425_-\|polysaccharide-export-protein	unknown	unknown	gnl\|CDD\|224512
NC_011757.1\|WP_015822389.1\|2284822_2287342_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|366183
NC_011757.1\|WP_003601813.1\|2277998_2278532_-\|DUF3280-domain-containing-protein	unknown	unknown	gnl\|CDD\|371669
NC_011757.1\|WP_015950718.1\|2290414_2291674_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_011757.1\|WP_015950709.1\|2277242_2277953_-\|(5-formylfuran-3-yl)methyl-phosphate-synthase	unknown	unknown	gnl\|CDD\|235014

Protein	Function_ID	Function_description	E-value
NC_011757.1\|WP_015950712.1\|2281278_2281713_+\|hypothetical-protein	gnl\|CDD\|259872	cd04210, Cupredoxin_like_1, Uncharacterized Cupredoxin-like subfamily. Cupredoxins contain type I copper centers and are involved in inter-molecular electron transfer reactions. Cupredoxins are blue copper proteins because they have an intense blue color due to the presence of a mononuclear type 1 (T1) copper site. Structurally, the cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel. Some of these proteins have lost the ability to bind copper. Majority of family members contain multiple cupredoxin domain repeats; ceruloplasmin and coagulation factors V/VIII have six repeats; Laccase, ascorbate oxidase, and spore coat protein A, and multicopper oxidase CueO contain three repeats; and nitrite reductase has two repeats. Others are mono-domain cupredoxins, such as plastocyanin, pseudoazurin, plantacyanin, azurin, rusticyanin, stellacyanin, quinol oxidase and the periplasmic domain of cytochrome c oxidase subunit II.	2.33844e-07
NC_011757.1\|WP_003607156.1\|2298689_2298950_-\|PepSY-domain-containing-protein	gnl\|CDD\|379323	pfam13670, PepSY_2, Peptidase propeptide and YPEB domain. This region is likely to have a protease inhibitory function (personal obs:C Yeats). The name is derived from Peptidase & Bacillus subtilis YPEB.	1.17039e-13
NC_011757.1\|WP_015950722.1\|2299099_2300638_+\|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl\|CDD\|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	0
NC_011757.1\|WP_015950710.1\|2278764_2280033_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|274821	TIGR03863, PQQ_ABC_bind, ABC transporter, substrate binding protein, PQQ-dependent alcohol dehydrogenase system. Members of this protein family are putative substrate-binding proteins of an ABC transporter family that associates, in gene neighborhood and phylogenomic profile, with pyrroloquinoline-quinone (PQQ)-dependent degradation of certain alcohols, such as 2-phenylethanol in Pseudomonas putida U. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NC_011757.1\|WP_015950719.1\|2292646_2295061_+\|LPS-biosynthesis-protein	gnl\|CDD\|225747	COG3206, GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane].	6.76635e-76
NC_011757.1\|WP_003601795.1\|2288263_2288623_+\|hypothetical-protein	gnl\|CDD\|234609	PRK00068, PRK00068, hypothetical protein; Validated.	0.000154502
NC_011757.1\|WP_003601804.1\|2282000_2282750_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|274822	TIGR03864, PQQ_ABC_ATP, ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system. Members of this protein family are the ATP-binding subunit of an ABC transporter system that is associated with PQQ biosynthesis and PQQ-dependent alcohol dehydrogenases. While this family shows homology to several efflux ABC transporter subunits, the presence of a periplasmic substrate-binding protein and association with systems for catabolism of alcohols suggests a role in import rather than detoxification. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	9.2588e-127
NC_011757.1\|WP_003601813.1\|2277998_2278532_-\|DUF3280-domain-containing-protein	gnl\|CDD\|371669	pfam11684, DUF3280, Protein of unknown function (DUF2380). This family of proteins with unknown function appears to be restricted to Proteobacteria.	3.15992e-49
NC_011757.1\|WP_015950720.1\|2296029_2297910_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|236382	PRK09111, PRK09111, DNA polymerase III subunits gamma and tau; Validated.	0
NC_011757.1\|WP_015950711.1\|2280199_2281186_+\|YVTN-family-beta-propeller-repeat-protein	gnl\|CDD\|274824	TIGR03866, PQQ_ABC_repeats, PQQ-dependent catabolism-associated beta-propeller protein. Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.	0
NC_011757.1\|WP_015950714.1\|2282746_2283640_+\|ABC-transporter-permease	gnl\|CDD\|163573	TIGR03861, ABC_efflux_transporter_permease_protein, alcohol ABC transporter, permease protein. Members of this protein family, part of a larger class of efflux-type ABC transport permease proteins, are found exclusively in genomic contexts with pyrroloquinoline-quinone (PQQ) biosynthesis enzymes and/or PQQ-dependent alcohol dehydrogenases, such as the phenylethanol dehydrogenase PedE of Pseudomonas putida U. Members include PedC, an apparent phenylethanol transport protein whose suggested role is efflux to limit intracellular concentrations of toxic metabolites during phenylethanol catalysis. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	4.09385e-117
NC_011757.1\|WP_012253408.1\|2295615_2295939_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	1.93994e-39
NC_011757.1\|WP_003601790.1\|2291846_2292425_-\|polysaccharide-export-protein	gnl\|CDD\|224512	COG1596, Wza, Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis].	1.70025e-30
NC_011757.1\|WP_015822389.1\|2284822_2287342_+\|TonB-dependent-receptor	gnl\|CDD\|366183	pfam00593, TonB_dep_Rec, TonB dependent receptor. This model now only covers the conserved part of the barrel structure.	1.13485e-33
NC_011757.1\|WP_015950717.1\|2288726_2290283_-\|undecaprenyl-phosphate-glucose-phosphotransferase	gnl\|CDD\|274396	TIGR03023, Sugar_transferase., Undecaprenyl-phosphate glucose phosphotransferase. This family of proteins encompasses the E. coli WcaJ protein involved in colanic acid biosynthesis, the Methylobacillus EpsB protein involved in methanolan biosynthesis, as well as the GumD protein involved in the biosynthesis of xanthan. All of these are closely related to the well-characterized WbaP (formerly RfbP) protein, which is the first enzyme in O-antigen biosynthesis in Salmonella typhimurium. The enzyme transfers galactose from UDP-galactose (NOTE: not glucose) to a polyprenyl carrier (utilizing the highly conserved C-terminal sugar transferase domain, pfam02397) a reaction which takes place at the cytoplasmic face of the inner membrane. The N-terminal hydrophobic domain is then believed to facilitate the "flippase" function of transferring the liposaccharide unit from the cytoplasmic face to the periplasmic face of the inner membrane. Most of these genes are found within large operons dedicated to the production of complex exopolysaccharides such as the enterobacterial O-antigen. Colanic acid biosynthesis utilizes a glucose-undecaprenyl carrier, knockout of EpsB abolishes incorporation of UDP-glucose into the lipid phase, and the C-terminal portion of GumD has been shown to be responsible for the glucosyl-1-transferase activity.	2.92824e-178
NC_011757.1\|WP_015950718.1\|2290414_2291674_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	1.41871e-46
NC_011757.1\|WP_015950709.1\|2277242_2277953_-\|(5-formylfuran-3-yl)methyl-phosphate-synthase	gnl\|CDD\|235014	PRK02227, PRK02227, (5-formylfuran-3-yl)methyl phosphate synthase.	3.93126e-75

>NC_011757.1|WP_015822389.1|2284822_2287342_+|TonB-dependent-receptor
MRVLRGSLIASVALLPGHVMAQGAGGGQAVTLEEISVVSNTPVAASRRVVATQTPSGLREVTVLDGIDRNKLPQNTSVLTSGDVSRVGFPSTVRALDERVGSISVNNAQGNPFQPTITYRGFEASPLGGSPQGVAVYLNGARFNTSFGDTVQWDLIPDIAVDRIELEGSNPAFGLNALGGSLAVTLKNGFTYQGSEINVLGGSFGRGAVAFQHGQRIDNIGLYVAGTKLGEDGWRKHSPSRLNQIYADLGVQGEKSEFHFNVIGASNSLTGNGTAPVELLKADRSDVFTYPDQTKNDFLRFQLSGTYDVTPTITVQGNAYYGLFRQRTANGDAADVENCEVDERFVCSEGADDNQFFLRDRTGSPVRTDRLRTFNFGGINPTFADRFDEGGPYAFLNQTRTSTDNFGATVQTVIRETLFGLPNRFVLGGQYDGGRTRFGADNSIGGLTLDRGFSPPGIVVSSDDGIITPVSVHTSNDYGGIYFSNNTDLTDRLTLTLQGRFNMAKIVLRDQIGTALNGDHYYQRFNPGVGATYKVIPDYLVAYGGYTEANRAPTPAELSCADPLAPCSLTNFFVGDPPLKQVVARTVEAGVRGRIPQPDEYFGGILSWKAGFFSTRNDDDILFVPAPDTIGRAFFRNVGSTKRQGVEASLFYNAPRWNAFIDYAFVDATFESPVELAAPGNPFNSAGGDESGVVLVRPGNRLPGVAPHQLKVGVQYQVTPEWRVGALARFATGKFLVGDPTNQNKTTGDFAVVGLNTSYRVASNIELYGYIENAFNANYATFGTFSPVNEVPIVRVPNATSNRSLAPGAPVAAFGGLRILFEPPPAAPVVEPFPLVRKG
>NC_011757.1|WP_015950715.1|2283650_2284280_+|hypothetical-protein
MIPRSVRAPLCLALILAAGPVLAQPKADPDWPCPQRKVTTLGYGSFWTGPDLAEAGEWGSDREAAQLARKLASRRTELREVDALLDEFAQKADPAEKGKRLTRVFAGVFEIINGERSTVMNGISRYAQGQRRLAERIRDEADKVSEFKDSPESDSTKVASKEVADLESRFNWDRRIFDERNQSVSYVCEVPTILEQRLGEIARRIQAHL
>NC_011757.1|WP_015950714.1|2282746_2283640_+|ABC-transporter-permease
MRSPSNPAVTARAEDGAKPVPHAGRLDAVGYLIALGGIVRRELLRFFHQKERFFSAMVRPLVWLFIFAAGFRNTLGTSITPPYETYVLYEAYVVPGLAVMIQLFNGMQSSLSMVYDREVGSMKVLLTSPYPRWSLLLAKLVAGVSVSIVQAYAFLAIAWFWETGIPPLGYLAALPAFLASGLMLGAIGLFLSSLVRQLENFASVMNFVIFPMFFASSALYPLWQVRASSEWLYLICQANPFTHAVELVRFALYGRFEPVACAVVVGTGLLFFTLAAIAYDPGRGIMARRGGPAGEAA
>NC_011757.1|WP_003601804.1|2282000_2282750_+|ATP-binding-cassette-domain-containing-protein
MSAALEVAGVSHRFGQRAALSDVSITVERGHFMALLGPNGAGKTTLFSVITRLYNNQEGRVSILGHPLDREPSRALAGLGVVFQARTLDTDLTVAQNLHYHASLHGIGRAAARARIETLLARVGLAERRDDKIRTLSGGQSRRIEIARSLIHAPRLLLLDEPTVGLDLESRADIVAIVRALVREEGLSVLWATHIFEEISPEDDAVVLHKGRIVARGRAGEIGGPGETLEAAFRRLVAEPDKRAVKSAA
>NC_011757.1|WP_015950713.1|2281725_2282004_+|hypothetical-protein
MMRTRTSLAVPKGFRGGALLALMALATPALADDKAACAEGISAVKAQAEKLAPEAVPQKLKRALKIAEREQGEGEFDECLEALDDAKRALPK
>NC_011757.1|WP_015950712.1|2281278_2281713_+|hypothetical-protein
MKWTTRLGLAAAALMLAAAPAGALDLTKKRQNLPDLVLGNEEGNDFVVENKDIELEAGKAYRLRIVAKGRQEYKFYAPEFFRHIWFNQIVIEHKEIHGGGPPDHLEFDDPGEIAIEFVAIKPGAYKWYAQGLEEKGMAGTITVK
>NC_011757.1|WP_015950711.1|2280199_2281186_+|YVTN-family-beta-propeller-repeat-protein
MVARLRAGLGCALLAGVSLGSAGSAQAFTAYVTNEKANTVSAIDTETLAVTGTWKVGRRPRGVTLSKDDKELFVCASDDDRIDVLDTATGKVVRSLRSGPDPEQFILDQSGNPLYVANEDDSQVTILDIEKNKVLAEVPVGVEPEGMGLSPDGNILVNTSETTNMAHFIDTKTFEVIDNVLVDARPRFAEFSADGKFLWVSAEVGGTVSVIDVATRKVIKKITFKIPSVTDEQIQPVGVRLTKDGTRAFVALGPANRVAVVDAKTYEVQKYLPVGQRVWQLAFTPDEKQLYTTNGTSNDVSVIDVEGLKVVKSIPVGLLPWGVAISKK
>NC_011757.1|WP_015950710.1|2278764_2280033_+|ABC-transporter-substrate-binding-protein
MRLSVPLLLAAGLATGPAAFLAASIHASAQEPKAATGEPPPGSPANETPAPVPGSETHIAVLYRPVPAPSSYDAEADPEDLGVAGARMAVKDNNTTGRFTKQTFALDEVALDGERDPVEAAKALADKGVRFFVLALPAAEVLAVADALKETGAVILNAGAPDDRLRGADCRTNLFHVLPSRAMQTDALAQYLTLMRWRKIFLITGPTERDKAYADAMRNSARKFGLKITAEKPWTFGPLAKARGDTPTRAEAMVFTRGLDYDLAVVADEEGDWGDYVPFRTVDPRPVAGTQGLIATTWHPTLETWGAAQAQNRFRRLASRLMRPLDYQVWAAVRTVGEAATQTRSTDPATLAAHLVKPEFSLPAYKGVSLTYRPWDHQLRQPIIVVQPKAMVSVAPEQGFIHQRTPLDTLGADMPETACKLP
>NC_011757.1|WP_003601813.1|2277998_2278532_-|DUF3280-domain-containing-protein
MRLRALVPALLPALTLLSTLNGAASAEDAARKAAIFPAEVNDPTLAYGRKPLPADQKRLDLVTDVLRKQLAEKGGLESVDLSPQAEEIRKESPLYKCNDCVAPIAKALGAELAVTAFADKGANQLFSLVVTIAEAETGKVVRRGQVVIRANTDDDWSHATRWIVKNRLLAEPLPGRS
>NC_011757.1|WP_015950709.1|2277242_2277953_-|(5-formylfuran-3-yl)methyl-phosphate-synthase
MSDIVSISSARPRLLVSVRGPDEALTALRAGADLIDAKDPERGALGALPPETVRAIVAGVGGQAVTSAVAGDGTGREIAAAIATIAATGVDFIKIAVGAANDAALAEAAAQAPGRVIGVLFAEDDVAEDGPARLAAAGFVGAMIDTRGKSGTTLTSHMATPQLAAFVAGCRTHGLMSGLAGSLGLGDIPALARLDPDYLGFRGGLCRASDRRQPLDGARVAQAVEAMRAGPRADAA
>NC_011757.1|WP_003601795.1|2288263_2288623_+|hypothetical-protein
MRIALTLPVALAVLVTAGPALAVSCKDDISTVERRLNSAGAEQVTGKEPPGGVTSSNSPKALDKPPAGAPSDPSTKPTKAGVEEARTLLAKAKEQEKAGQETACQDTMTKVKEKAGALP
>NC_011757.1|WP_015950717.1|2288726_2290283_-|undecaprenyl-phosphate-glucose-phosphotransferase
MSAIDVRDLLKVARENGALTSVPTPLVLHSDENSDSAPSASNPAPTPPKGAWLSPVVLAGCVRLAEFCGLILLGLALHQALLRGVVPLAPRYHAAILAVTLAALGLFQASGSYRISAFRDLPRTAVKLATGWSIAFLMVAAAMVLAKVADHYSRIWLLSYYMAGLGILLGGRAALSAFVRMQMAKGRFDRRTAIVGGGPAAVELIHALEASGDNGIRIIGIFDDRGDDRSSTDVAGYPKLGNVSDLVTYARHAPVDLVVFTLPISAETRILQMLAKLSVLPVDIRLSAHATKLRLRPRAYSYLGGVPLLDVFDKPLADWDVILKGAFDRVVGLLLLLGLSPAMIAVALAVKLTSPGPVLFRQKRYGFNNELIEIFKFRSMYVDLCDAGASQLVTKTDARVTPVGRFIRKTSLDELPQLFNVIRGDLSLVGPRPHAVQAKAANTLYDQVVDGYFARHKVKPGITGWAQINGWRGETDTSEKLQRRVEHDLHYIENWSILFDLKILLTTPLALFKTDNAY
>NC_011757.1|WP_015950718.1|2290414_2291674_-|glycosyltransferase-family-4-protein
MASPFAVPLTAALTPQGPTGHAIADLSSRVGTGERHRILHVFRAPVGGLFRHVIDLTRLQAEAGHAVGLVCDASTGGERAERTLADLAPYLALGVTRVPMRRNPHASDLHVLRTVRAQALAVGADVLHGHGAKGGVFARLAPLGRAGRGVIRAYTPHGGSYNYRPGTTLHRVYMAAEQVMARATDLFLFESEYVASRHAAFAGGSPRLERIVHNGIAEAEFAPVETADDPFDLVYVGELREAKGLPVLLRALARLRGQGRELRLLMVGSGPDTESIAAMAENLGLRHAIAFEPPQAIRPVLGRGRVMVVPSLAESLPYVVLEAAAAGQPLVATNVGGIPEIFGAFSSDLVPPGDCEALSTAILHILDEEPSRRQGRARALSNSLRTRFSMNRMATDVLCGYAAAFSAKRMRTASVPATA
>NC_011757.1|WP_003601790.1|2291846_2292425_-|polysaccharide-export-protein
MAMQRRAFLLALPSVLALGGCLRPDFRTVDLDATGTGSIGTRYSLAAGDKLRVIVFGQDNLSNIYAVDGGGRIAMPLIGVVQVGGQTTAQAARLIESKLAAGYVREPHVTVEVDAYRPFYILGEVTTSGQYPYVNGMTVETAVAIAAGFGPRAARDYAVLTREGQGGLINGIVPMSYPVRPGDTIVVKERFF
>NC_011757.1|WP_015950719.1|2292646_2295061_+|LPS-biosynthesis-protein
MPRLRLSTDPSLPPSGGPGGPGDGLAVAQIGGVLRRSWAWIAVPTLVAALGAGVFVQVVTPRYTGEAKVLLESRDPAFARTAAERTDQTQPIDEQAVASQVQVAMSRDIAREAIRSLKLVGNPEFDPEAEGSSAIRRTLMMLGLVSAPMDRPSEDRILESYLDHLLVYPVGKSRILAVEFRSRDPELAARGANTVADLYLASLEAASVDTARYASTWLGNNIANLRARVAEAEAKVEAFRAKHGLIGTGSSAAAQPLSSQQLSELSSQLSQARTIQADLTARAKLLKDMIKEGRAFEIPDVANNELIRRTVESRMAMRAQLALESRTLLPAHPRIKELTAQVQDLENQIKAAAERVVRTLENDAKIAGARVESLRAAVEGQQDVVAKGNTSEVELRALEREAKSQREQLESYLARYREAAARDAENASPANARVVSRAIVPDLPSFPKKLPIVAFATMLAFLLASAGVIGRHLLVTPAGPGGDRTGDEGEPLVQSTRTDRPRDFYPEPEPPPSRRPAYEPVYGGAYPASAAERFAPALAFAHSLRATATVHHPVFASTAPIGAEAAAQADGAKTDKEGFGVPAKSSASSADLDGLIARLANGTGKGQGKEQGNGPLAGPSKGGCVLVVETPRADGTPGLASNLARVLGPRYQTLLVDVNGVVSGPSEPGLTDLVAGAADFLDVIQPVRGSRLHAVKRGAAPLDVLVEEPQGLAIGLNALSQSYDWVLCRLDARHAEDGADLIPAVGPCMDSIVIASDAASDDPALVSLYRLAKETGVARVVVARHGEDADLTPSLEGTPLRLSA
>NC_011757.1|WP_012253408.1|2295615_2295939_-|YbaB/EbfC-family-nucleoid-associated-protein
MRDLMGIMKQAQAMQEKMASVQSELEAVEVSGASGGGAVTVRMTAKGQVLGVSIDPSLMVADEREILEDLIVAACNDARGKAEATAQEKMAELTKGLPLPPGMKLPF
>NC_011757.1|WP_015950720.1|2296029_2297910_-|DNA-polymerase-III-subunit-gamma/tau
MDETHGTLTDEPGLPGMPTPAPVPATTPYRVLARKYRPQTFDDLIGQGAMVRTLGNAFAANRIPQAWMLTGVRGVGKTTTARILARGLNYLRTGQPDTGPTVSMPELGQHCQAIMESRHMDVLEMDAASHTGIDDVRGIIDGIRYSPVSARYKVYIVDEVHMLSEKAFNAFLKTLEEPPPHAKFVFATTEIRKVPVTILSRCQRFDLRRVEADVLAAHLKKICAAEGVEAEDEALAAVTRAAEGSVRDALSLLDQAIAHGAGAVSAAGVRDMLGLADRSRIVDLFEAVMRGDVPAAFAEIRAQYDAGADPAVVLSDLAGFTHLVTRLKLVPGAEADPTLSEAERVRGVAFAGRLPVRALSRAWQILLKALPEVQAAPRPLAAAEMAIVRLAYAADLPTPDEALRQLRADIASSEGNGAARPSLGRDGGSPMASHGSAALQMAPPAPQPSPRPTLAAVPSPVTAAAPQPASRPAPVAPAGPRLGRFEDVVAQAEAARDIALKVALERDVHLVRFEEGRIEFRLAPGGRQSLPTDLARALDAWTGRRWLVALSKEQGAPTLAENTRAAEETRHQNAAAHPLVREVLSRFPGAQIVDVRDKAPETDSADAAANGAGPAAPPPEETDDDA
>NC_011757.1|WP_015950721.1|2298166_2298655_+|hypothetical-protein
MRTNTIPARLAVLALLAILPVPAGAQDRTGGPAQEGAPKDWQGRYRYEHAAGRTAGGTGIVVTYDLVLLPPDVGDGCVLTIRGFQSDETLRCRTRREGQDLAVTFDRYGDGRTVNRYGVAVYKPGQPLFTLAKGAALATRWQGLKPDGQGVADRGAYFKKVR
>NC_011757.1|WP_003607156.1|2298689_2298950_-|PepSY-domain-containing-protein
MSFRPLAAFAIGFALLSGPVLADEKLPPDQQAKVEDILKKEGFTKWKEIELDDGMIEVDDAIDANGKQFDLKLDPKTLEVVKRKAE
>NC_011757.1|WP_015950722.1|2299099_2300638_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MVTRVATVAFEGIEARAVDVQVQIAAGAVAFTIVGLADKAVAESRERVRSALIASGLALPAKRITVNLAPADLPKEGSHYDLPIALAVMGAIGALPADALGGYCVLGELALDGSITAVAGVLPAAMAANGRGLGLICPAATGPEAAWAAGDMDVLAPRSLIQLANHFKGSQVMARPQPAVAAPAGPMSDLRDIKGQEGAKRALEIAAAGGHNLLMNGPPGAGKSMLAARLPSILPPLGPRELLEVSMIQSVAGELKGGALSNRRPFRQPHHSASMAALVGGGLNARPGEASLAHGGVLFLDELPEFTPQVLDSLRQPMETGEIMIARANHRTTYPARFQLVAAMNPCRCGMALEPGYACRRGPNERCVAQYGARISGPLLDRIDLRIEVAAVTAADLILPPPAEGSAEAAARVAAARALQSARYAALGLPAATTNATCPATVIESAAAPDAEGAALIRHAAETMRLSARGFHRTLRVARTLADLDGEAQVRRLHLAEALSYRARGERPAAAA

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Crispr_ID: NC_011757_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_011757_2

4414114-4414205

Orphan

Consensus_repeat	Method
ACCGTGTCGTAGATCGGCGGCGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_011757_2

>merge|NC_011757|2|4414114-4414205|CRISPRCasFinder
ACCGTGTCGTAGATCGGCGGCGTGGTGCGGTAGACGGTGCGCGGCGGCTGGACCAGCACGCGCTCCGCGACGGTGTCGTAGATCGGCGGCGT

>NC_011757|2|2|4414114-4414205|CRISPRCasFinder
ACCGTGTCGTAGATCGGCGGCGT	GGTGCGGTAGACGGTGCGCGGCGGCTGGACCAGCACGCGCTCCGCG
ACGGTGTCGTAGATCGGCGGCGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_011757.1\|WP_003599505.1\|4411082_4412027_+\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|234929
NC_011757.1\|WP_003599510.1\|4415669_4416260_+\|CarD-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224248
NC_011757.1\|WP_015952122.1\|4423621_4424587_+\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|237512
NC_011757.1\|WP_015952113.1\|4408971_4410543_+\|exodeoxyribonuclease-VII-large-subunit	unknown	unknown	gnl\|CDD\|234714
NC_011757.1\|WP_015952115.1\|4412633_4413632_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|176248
NC_011757.1\|WP_015952114.1\|4412148_4412613_-\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|180535
NC_011757.1\|WP_015952119.1\|4421161_4421527_+\|DUF971-domain-containing-protein	unknown	unknown	gnl\|CDD\|377616
NC_011757.1\|WP_015952110.1\|4405859_4406303_-\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NC_011757.1\|WP_193373781.1\|4425693_4427112_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270277
NC_011757.1\|WP_012255066.1\|4407707_4408445_+\|hypothetical-protein	unknown	unknown	unknown
NC_011757.1\|WP_015952120.1\|4421593_4423336_+\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|181346
NC_011757.1\|WP_003599504.1\|4410687_4410915_+\|DUF4170-domain-containing-protein	unknown	unknown	gnl\|CDD\|372720
NC_011757.1\|WP_003599511.1\|4416542_4417415_+\|RNA-polymerase-factor-sigma-32	unknown	unknown	gnl\|CDD\|236033
NC_011757.1\|WP_015952121.1\|4423377_4423611_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|319884
NC_011757.1\|WP_015952111.1\|4406316_4407624_-\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|234856
NC_011757.1\|WP_015952118.1\|4418668_4420336_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|214861
NC_011757.1\|WP_158020166.1\|4424822_4425521_+\|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|223736
NC_011757.1\|WP_015952109.1\|4405066_4405768_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187631
NC_011757.1\|WP_015952112.1\|4408522_4408747_+\|hypothetical-protein	unknown	unknown	unknown
NC_011757.1\|WP_003599509.1\|4414812_4415151_+\|ferredoxin-family-protein	unknown	unknown	gnl\|CDD\|378771

Protein	Function_ID	Function_description	E-value
NC_011757.1\|WP_003599505.1\|4411082_4412027_+\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	0
NC_011757.1\|WP_003599510.1\|4415669_4416260_+\|CarD-family-transcriptional-regulator	gnl\|CDD\|224248	COG1329, COG1329, Transcriptional regulators, similar to M. xanthus CarD [Transcription].	3.87805e-66
NC_011757.1\|WP_015952122.1\|4423621_4424587_+\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|237512	PRK13800, PRK13800, fumarate reductase/succinate dehydrogenase flavoprotein subunit.	4.9765e-24
NC_011757.1\|WP_015952113.1\|4408971_4410543_+\|exodeoxyribonuclease-VII-large-subunit	gnl\|CDD\|234714	PRK00286, xseA, exodeoxyribonuclease VII large subunit; Reviewed.	0
NC_011757.1\|WP_015952115.1\|4412633_4413632_-\|oxidoreductase	gnl\|CDD\|176248	cd08288, MDR_yhdh, Yhdh putative quinone oxidoreductases. Yhdh putative quinone oxidoreductases (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
NC_011757.1\|WP_015952114.1\|4412148_4412613_-\|transcription-elongation-factor-GreA	gnl\|CDD\|180535	PRK06342, PRK06342, transcription elongation factor GreA.	2.98145e-49
NC_011757.1\|WP_158020166.1\|4424822_4425521_+\|cyclic-nucleotide-binding-domain-containing-protein	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	4.54674e-34
NC_011757.1\|WP_015952110.1\|4405859_4406303_-\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	6.96286e-61
NC_011757.1\|WP_193373781.1\|4425693_4427112_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270277	cd13559, PBP2_SsuA_like_3, Putative substrate binding domain of sulfonate binding protein-like, the type 2 periplasmic binding protein fold. This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.20652e-119
NC_011757.1\|WP_015952121.1\|4423377_4423611_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|319884	cd10562, FDH_b_like, uncharacterized subfamily of beta subunit of formate dehydrogenase. This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.	3.96446e-07
NC_011757.1\|WP_015952120.1\|4421593_4423336_+\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|181346	PRK08275, PRK08275, putative oxidoreductase; Provisional.	0
NC_011757.1\|WP_003599504.1\|4410687_4410915_+\|DUF4170-domain-containing-protein	gnl\|CDD\|372720	pfam13773, DUF4170, Domain of unknown function (DUF4170).	1.38903e-43
NC_011757.1\|WP_003599511.1\|4416542_4417415_+\|RNA-polymerase-factor-sigma-32	gnl\|CDD\|236033	PRK07500, rpoH2, RNA polymerase factor sigma-32; Reviewed.	1.51428e-174
NC_011757.1\|WP_015952111.1\|4406316_4407624_-\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NC_011757.1\|WP_015952118.1\|4418668_4420336_-\|recombinase-family-protein	gnl\|CDD\|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	1.78838e-36
NC_011757.1\|WP_015952109.1\|4405066_4405768_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187631	cd05373, SDR_c10, classical (c) SDR, subgroup 10. This subgroup resembles the classical SDRs, but has an incomplete match to the canonical glycine rich NAD-binding motif and lacks the typical active site tetrad (instead of the critical active site Tyr, it has Phe, but contains the nearby Lys). SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	4.10717e-86
NC_011757.1\|WP_015952119.1\|4421161_4421527_+\|DUF971-domain-containing-protein	gnl\|CDD\|377616	pfam06155, DUF971, Protein of unknown function (DUF971). This family consists of several short bacterial proteins and one sequence from Oryza sativa. The function of this family is unknown.	1.11822e-24
NC_011757.1\|WP_003599509.1\|4414812_4415151_+\|ferredoxin-family-protein	gnl\|CDD\|378771	pfam11953, DUF3470, Domain of unknown function (DUF3470). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is about 50 amino acids in length. This domain is found associated with pfam00037. This domain has a single completely conserved residue N that may be functionally important.	9.75193e-20

>NC_011757.1|WP_015952115.1|4412633_4413632_-|oxidoreductase
MAAFRAWVIEKGEAGQSLALRDFDEADLMDGDVTVRVSHSGLNYKDGLAMTGRMPVVRRFPMIPGIDFAGTVEASAHPDYKAGDAVVLTGWGVGETHLGGLSERARVRGDWLVPLPEGLSPAEAMAIGTAGYTAMLSVLALERHGLTPEAGPALVTGASGGVGSVAVALLKRAGWHVIAATGRSGEAGYLKGLGAAEILEREALAGEPRPLAKERWAAGIDAVGGRVLANVLSMTKGGGAIAACGNAGGMDLPSSVAPFILRGVSLLGINSVTTPQGPRREAWARLARDLDRDRLKAMTRTVSLEEAGGLAETLLDGQVRGRTVVAIGGTAA
>NC_011757.1|WP_015952114.1|4412148_4412613_-|transcription-elongation-factor-GreA
MSRAFVREPEGGEAFEDLPDRPISSHTNFVTPEGLAQIEAEVARLEAELSGLSPQQDKADHIRVSRDLRYWTARKNSAEPVEAFEGDTVRFGATVTVLREDDTRQTFRIVGEDEADPSAGSISYVAPLAQALTGKGVGDTVTVNDHEFEIAEIR
>NC_011757.1|WP_003599505.1|4411082_4412027_+|ribose-phosphate-pyrophosphokinase
MTSSIKIIAGNASRPLAEAIAGYLELPLANCMVRRFADMEIFVELQENVRGEDVFIVQSTSFPANDHLMELLIMIDAARRSSARRITAVIPYFGYARQDRRTSGRTPISAKLVCNLITEAGADRVLTLDLHAGQIQGFFDIPTDNLFAAPVMVRDIKERLAPGERMVVSPDVGGVVRARALAKRIDASLAIVDKRRERAGESEVMNIIGDVEGQSCILVDDIVDSGGTLVNAAEALLNAGAKEVSAYITHGVLSGGAVSRIAASRMKELVITDSILPTQAVKLARNIRVISIAPLLGEAIGRTATESSVSSLFT
>NC_011757.1|WP_003599504.1|4410687_4410915_+|DUF4170-domain-containing-protein
MTTTIDSDQKLHLVFGGELEDVSGVRFRDVKDLDIVGVFPDYASAQTAWRSKAQATVDNAQTRYFIVHLHRLLEP
>NC_011757.1|WP_015952113.1|4408971_4410543_+|exodeoxyribonuclease-VII-large-subunit
MPLVPPPRPATSAAAVPPPGEPAPSALLQANTPEWSVGDLAAALKRTLEDAFGHVRLRGEITGYRGPHGSGHAYFSLKDGSAKIDAVVWKGVLGRLRQKPKEGLEVVATGKITTFAGKSSYQIVIDSMEPAGIGAWMALLEERKRQLAAEGLFEAERKRPIPFLPRVIGVVTSPTGAVIRDILHRLEDRFPRPVLVWPVRVQGEGAAEEIAAAIRGFNALSPDGPIPRPDVLIVARGGGSIEDLWAFNEEAVVRAAAESEIPLISAVGHETDTTLIDFASDRRAPTPTGAAEMAVPVRAELAAQVHELGARQAGTMLRRIERERADFRALVRAIPGADAFLAVKRQRLDLADARLRPALAANARDSRERLNRVADRLTRRSPAIALAEARARLAAIDHRPRTAMSRIVERRRDRLDALTSLLGALSYKAVLARGYALVRDADGLPVRSAAAAARAARFQLQFADGAIFARPEEAPDDPVAPPLAEAPRSAPRPKRAPRRAAPEPAPKPEKAAAEPAARQGSLF
>NC_011757.1|WP_015952112.1|4408522_4408747_+|hypothetical-protein
MSAMPICRHSIAPPARPPREQPVVRLSHYVVQRRSAPRAANDNRRSRLAPVWPWAMAAAAAPAVTAALILTRLI
>NC_011757.1|WP_012255066.1|4407707_4408445_+|hypothetical-protein
MAPTDRQPDRHEGPGRKRRGLGLEGASTLVQTLAILGAGAWGVYTFVYEARIKPGLAPPSVSVKTDLARVGERGDRVAIRSTVTRTNVGQAGVRVLGLTYTVVGIRTRFSEPGDDTAAREAAFRASLSGTASVDAARDYVRESGGTPILRQGLLFSGATPLPSEPSDLNPGESVSRDVIVYADRKTFDAVRFEVRLAYAKEDDPPVRLRFEAGADGVLATVPAEPCPAPKCPLRSTDFATEFSLW
>NC_011757.1|WP_015952111.1|4406316_4407624_-|phosphoribosylamine--glycine-ligase
MTEPFSILLIGSGGREHALAWAIAKSPLCARLFIAPGNPGTAQHGENRPDLAVSDHAAVVAFCRAEGVGLVVVGPEAPLVAGLVDDLQAAGIPAFGPTKAAAQLEGSKGFTKDLCAEHDIPTAAFARFTDLEPALAYLRERGAPIVVKADGLAAGKGVTVAETLPEAEAAVRAILDGTEGGALVIEECLFGEEASFFALCDGTRAVPIGTAQDHKRVHDGDLGPNTGGMGAYSPASIVTPEITETVMTRIIAPTLAGMAARSTPFSGILYAGLMLTAEGPKLIEYNTRFGDPEAQVLMPRLTGDLVPALLAAAQGDLSGVAIGFDASRAALTVVMAAQGYPGAVTRGTEIRGVEAAEDEAGDATVLVFQAGTRRDGDRLLADGGRVLAVTALGASVGQAKDRAYAAVKRIDWPDGFFRSDIGGREVAREAASKGD
>NC_011757.1|WP_015952110.1|4405859_4406303_-|nucleoside-deaminase
MPDFLDLAFAAAREAAALGEVPVGAAVVRDGAVLAVAGNRPRTLCDPTAHAEILAIRAACAALSDERLTGCDLYVTLEPCPMCAGAIAFARIRRLYYAASDPKGGGVEHGPRVFNQPTCHHAPEVYSGFREGEAAGLLRDFFAERRG
>NC_011757.1|WP_015952109.1|4405066_4405768_-|SDR-family-NAD(P)-dependent-oxidoreductase
MVPTYQRALIVGAGPGLSASLARLFAAEGLKVGLAARNTEKLNDLAAETGAVIHACDATDPSAVEALFPRLEPALGGAPDVVVYNASGRLRGATVDLDPEAVARALSVSAYGGFLVAQAAARRMLPHRHGAILFTGASASVKGFAGSAPFAMGKFALRGLAQSLARELQPQGIHVAHVVIDGAIRSAARPDPEDHPDATLDPDAIAKGYLALLRQDRSAWTNEITLRPWVERF
>NC_011757.1|WP_003599509.1|4414812_4415151_+|ferredoxin-family-protein
MTYVVTDNCIKCKYMDCVEVCPVDCFYEGENMLVIHPDECIDCGVCEPECPAEAIKPDTEGDLESWLKLNADYAKTWPNITQKKDAPSDAKQWDGVSGKLEAHFSPNPGSGD
>NC_011757.1|WP_003599510.1|4415669_4416260_+|CarD-family-transcriptional-regulator
MTTAKKTTVAGRQGFKTGEAVVYPAHGVGRITAIEEQEIAGYKLELFVVSFEKDKMVLRVPTAKANSVGMRKLAEPELVKKALDVLTGRARIKRTMWSRRAQEYEAKINSGDLISVTEVVRDLFRSEAQPEQSYSERQLYEAALDRVVREISSVNKITETEALKLIEQSLAKSPRRAKADAEADAEGEDDVQEEAA
>NC_011757.1|WP_003599511.1|4416542_4417415_+|RNA-polymerase-factor-sigma-32
MAEIAGMRRQFIRTAMEAPFLARDEERGLAVAWKEARDERALHRLISAHMRLVIALAGRFRHYGLPMADLVQEGHVGLMEAAARFEPEREVRFSTYATWWIRASIQDYILRNWSIVRGGTSSAQKALFFNLRRLRARLMQSTEEQVGSEIHGRIATAIGVSREDVALMDARLSGPDMSLNAPVGEESEASSERMDFLVDNAALPDETVSALVDGERRLIWLRQALTVLSERELRILRERRLAEDQATLEALGHRLGISKERVRQIENRALEKLRRALAEKFPQAPSSVYA
>NC_011757.1|WP_015952118.1|4418668_4420336_-|recombinase-family-protein
MNHQTRKAPFVPVSDRPQRVGCYLRVSTGRQAEGDLSIPDQRKQVHAFCAAKGWPVVGEYVEPGASATDDNRPEFQKMIERAGDDDHPFDVIVVHSYSRFFRDSFGLEMYVRRLARAGVRLISITQELGDDPAQVMMRQVIALFDEYQSKENAKHVLRAMKENARQGFYNGSPVPLGYTVAEIEKRGARVKKRLAVDPVEAETVRLIFRLYRFGDGATGPLGVKAITCHLNERGYRTRAGARFGVATVHGILTNRVYVGEAFFNRRCSKTLAQKPAAEHIPISVPALIELPEFEAVQATLKAHNPRATPARVVTGPILLTGLATCTTCNGPMTLRTGTSKSGKVHRYYSCSTHGRMGRTGCTGRSIPMDTLDTLVTDHLVAELLQPDRLRATLASLWALRAEKAAQVDGRVAALRGEVCEAEEKLKRLYRMVEEGVTDLDDILKGRLAALKEDRDRARTALDRIHVAERAPAEIAPELVEKFGRLMRENVTSGEIPFRKAWLQAIVDRVEVDADVIRIVGEKASLEAAVIDAAPSAAPGVRSSVRKWRARKDSNL
>NC_011757.1|WP_015952119.1|4421161_4421527_+|DUF971-domain-containing-protein
MNPPQPPFDPEAVPTDAVVAHGGRDLRLTWANGEAAVLTSETLRLRCRCAWCTRDRIQGRFPEAFPAVAVTKIDPLGGYAVNLGFSDGHARGIFPWVYLRDLAREAAAPTTGATERAPRAA
>NC_011757.1|WP_015952120.1|4421593_4423336_+|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit
MSDTGPKVDIVETDLLVIGGGTGGPMAAIKAKEADPKLRVLLLEKANVKRSGAISMGMDGLNNAVVPGYATPEQYVKEITVANDGIVDQKAVMAYAQGSFPMIQYLDKLGVKFEKDGSGEYNMRKVHHMGTYVLPMPEGHNVKKVLYRQLRRLQVAVTNRYMATRLLKDADGRIAGAIAVNTRTSEFLIVKAKAVVLACGAAGRLGLPASGYLFGTYENAANCGDGYAMAYHAGAQLANLECYQINPLIKDYNGPSCAYVTGPFGGFTANNKGERFIECDYWSGQMMLEFWRELQGGNGPVFLKMDHLREETISEIETILHSNERPSRGRFHERRGTDYRKRPVEMHISEIGFCSGHSASGVFVDENARTTVPGLYAVGDMASVPHNYMLGAFVNGGIAGADAAAYCAATSRPAYDEGDVLAEQARVLAPTRRDDGLTPHEMEFKTRRLVNDYLEPPKVTAKMELGQRRFAEIRDDLDGLCARDPHELHRALEMQSILDCADMAAHASLYRTESRWGFYHLRVDHPETRPEWACHTVLFKDGKGRMASAKRAVDPFIVPVADEEMSAYHQLRIKTPVAAE
>NC_011757.1|WP_015952121.1|4423377_4423611_+|4Fe-4S-dicluster-domain-containing-protein
MPIITQAKSAAVVIDDDKCIAEKGCRVCVDVCPLDILAIDETRQKAYMKYDECWYCMPCEVDCPTNAVKVNIPYLLR
>NC_011757.1|WP_015952122.1|4423621_4424587_+|HEAT-repeat-domain-containing-protein
MAPVFDTFDDDIEELAERAASLDPGIRRVAMMELAEAVGAEAKVLLLKGLADDDATVRAAAAKALDEHDGADVVEGLVRSLEDADEDVRRVAAETLSEKKEPTCGPLLIERAEHADPFVQAAALRALRELVIPDALSAALKALQSPAPEVRREGLGVIGYLKAEEALPALLATARDGDATVRRATMAALVFLRSGGPGVATLLAGLQDENWQVREEAAISIAKSRLPEAVEPLIAAMTDPVWQVKTKAANALGRIKSTAAIDVLGRALDSEVSNLRKESAAALGEIAHPQALSFLERASDDPDPDVRKLIRWAIGRCRAEV
>NC_011757.1|WP_158020166.1|4424822_4425521_+|cyclic-nucleotide-binding-domain-containing-protein
MEAFPQPAGPRPLLEGLSESERNQVMERGRRRVLYRGATLFTQETPNDGIWLIETGRIRVFYAAPTGREITLAYWYPGNFVGGPEVFGSGSHSWSGMAASNSTVLHLPGAALKQLVARIPSLAFGIIDGLTFKGRCYSALAQMLGTRSITDRLAFLLIHLSNLYGVEEEGGVLIAADFTHADLAHMVGATRQWVTISLKRLSEQGVVTTRRSQILIQRPDILARMPGGDEAA
>NC_011757.1|WP_193373781.1|4425693_4427112_+|ABC-transporter-substrate-binding-protein
MMSRRSTVSALALLAAAGIATGAPAHAETVLNVGIGTQDTTTNTATVGVVVRQLKLIEKHLPKTGKYADVKIRLDWQNFTSGPPVTNGMMAGKLQFGAMGDYPLVVNGYTFQNNPESRSRLIAVAAYNIHGSGNGIVVNKETDAFSFDDLKGKVVSVPFGSAAHGMVLKALQDKGYPQSFFRLVNQSPEVGSTNLQEKKIDAHADFVPFAELLPFRGFARKVFDGVETNLPTWHGVVVRTDFAEKYPEIVDAYLQAILDAQAWVKADPKRAAEQIAAWTGTDKEVVYIFLGPGGIMTIDPTLKAPLIDAAKEDVKVLQKLDRVKEFDVASWVDDAPLRKAFAARGLDYDVQRTSTTNYEVSGEDGFCKRPITDPRKAGEIWVKDGDILPYASAACTLGAVNDITAKGREINVAYVFDTSRGIKLFAREAFYVVGGGEIAPYLLKRDAEAAAAKSGAKVLPYDEAVKAAVAGG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

43740 : 112536

Feldmannia_species_virus(11.11%)

integrase,transposase

attL 101519:101538|attR 116628:116647

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012605221.1\|43740_45246_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_012605222.1\|45543_47052_-	phospholipase D	NA	NA	NA	NA
WP_012605223.1\|47936_50369_+	PAS domain S-box protein	B5LWA6	Feldmannia_species_virus	3.0e-08	32.0
WP_012605224.1\|51178_51424_-	hypothetical protein	NA	NA	NA	NA
WP_012605225.1\|51542_52610_-	M42 family metallopeptidase	NA	NA	NA	NA
WP_009867550.1\|53375_54644_-\|transposase	IS256-like element ISMex3 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.5e-91	45.7
WP_012605228.1\|56765_57083_-	hypothetical protein	NA	NA	NA	NA
WP_012605229.1\|57563_57809_-	hypothetical protein	NA	NA	NA	NA
WP_012605231.1\|59437_59674_-	hypothetical protein	NA	NA	NA	NA
WP_012605232.1\|59670_60825_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012605233.1\|61093_61807_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_012605234.1\|61806_62067_+	hypothetical protein	NA	NA	NA	NA
WP_012605235.1\|62360_64874_-	PAS domain-containing protein	NA	NA	NA	NA
WP_012605236.1\|65142_65886_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_012605237.1\|65961_66474_+	DUF3280 domain-containing protein	NA	NA	NA	NA
WP_012605238.1\|66522_66729_-	hypothetical protein	NA	NA	NA	NA
WP_012605239.1\|67353_67593_+	hypothetical protein	NA	NA	NA	NA
WP_012605241.1\|68104_68266_-	hypothetical protein	NA	NA	NA	NA
WP_041928818.1\|68835_69102_-	hypothetical protein	NA	NA	NA	NA
WP_012605243.1\|70656_70860_-	hypothetical protein	NA	NA	NA	NA
WP_012605244.1\|70991_71453_-	hypothetical protein	NA	NA	NA	NA
WP_012605246.1\|73188_73758_+\|integrase	site-specific integrase	K4JX14	Caulobacter_virus	1.4e-20	34.7
WP_012605247.1\|73799_74081_-	DUF2312 domain-containing protein	A0A0F6R615	Sinorhizobium_phage	2.1e-14	50.6
WP_012605248.1\|74138_75338_-	hypothetical protein	NA	NA	NA	NA
WP_012605249.1\|75405_75591_+	hypothetical protein	NA	NA	NA	NA
WP_012605250.1\|75595_76063_+	hypothetical protein	A0A067XQB2	Caulobacter_phage	1.2e-41	52.0
WP_012605252.1\|76823_77417_+	MucR family transcriptional regulator	A0A1P8VVG0	Erythrobacter_phage	4.4e-22	41.2
WP_193373763.1\|77440_77689_-	prolyl oligopeptidase family serine peptidase	NA	NA	NA	NA
WP_012605254.1\|77827_78730_-	restriction endonuclease	A0A1B1IUE7	uncultured_Mediterranean_phage	8.6e-09	32.6
WP_012605255.1\|79023_80214_-	DUF3644 domain-containing protein	NA	NA	NA	NA
WP_012605256.1\|80613_81936_-\|integrase	integrase	NA	NA	NA	NA
WP_012605257.1\|82274_83273_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_012605258.1\|83581_83803_+	WGxxGxxG-CTERM domain-containing protein	NA	NA	NA	NA
WP_012605259.1\|84325_85264_-	homocysteine S-methyltransferase family protein	NA	NA	NA	NA
WP_012605260.1\|85732_86107_-	response regulator	NA	NA	NA	NA
WP_012605261.1\|86873_87816_+\|transposase	IS630 family transposase	A0A1V0SCG6	Indivirus	6.2e-10	21.7
WP_041928827.1\|87836_88502_-	hypothetical protein	NA	NA	NA	NA
WP_193373769.1\|88686_89010_-	phasin family protein	NA	NA	NA	NA
WP_012605264.1\|89404_89905_+	hypothetical protein	NA	NA	NA	NA
WP_012605265.1\|90421_91237_+	universal stress protein	NA	NA	NA	NA
WP_012605267.1\|91561_91825_-	hypothetical protein	NA	NA	NA	NA
WP_012605268.1\|92144_92657_+	DUF3280 domain-containing protein	NA	NA	NA	NA
WP_012605239.1\|93536_93776_+	hypothetical protein	NA	NA	NA	NA
WP_012605240.1\|93794_94088_-	hypothetical protein	NA	NA	NA	NA
WP_012605241.1\|94287_94449_-	hypothetical protein	NA	NA	NA	NA
WP_012605270.1\|95018_95285_-	hypothetical protein	NA	NA	NA	NA
WP_012605271.1\|96286_96439_-	hypothetical protein	NA	NA	NA	NA
WP_012605273.1\|97280_104309_-	heme peroxidase	NA	NA	NA	NA
101519:101538	attL	NA	NA	NA	NA
WP_041928836.1\|104802_105057_+	hypothetical protein	NA	NA	NA	NA
WP_012605275.1\|105053_105320_+	hypothetical protein	NA	NA	NA	NA
WP_041928841.1\|106210_106447_-	hypothetical protein	NA	NA	NA	NA
WP_012605276.1\|106595_108290_+	acyltransferase	A0A2H4JA46	uncultured_Caudovirales_phage	2.8e-05	29.5
WP_012605277.1\|108483_108855_+	hypothetical protein	NA	NA	NA	NA
WP_012605278.1\|109024_110029_+	M23 family metallopeptidase	NA	NA	NA	NA
WP_158020048.1\|110041_111037_-	AAA family ATPase	NA	NA	NA	NA
WP_012605280.1\|111213_112536_-\|integrase	integrase	NA	NA	NA	NA
116628:116647	attR	NA	NA	NA	NA

DBSCAN-SWA_2

240256 : 267836

uncultured_Caudovirales_phage(22.22%)

head,portal,capsid,terminase,integrase

attL 234962:234977|attR 267243:267258

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
234962:234977	attL	NA	NA	NA	NA
WP_012605388.1\|240256_241786_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012605389.1\|242064_243291_+\|integrase	site-specific integrase	A0A077KET4	Ralstonia_phage	9.6e-88	46.2
WP_012605390.1\|243212_243455_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012605391.1\|243570_243789_+	hypothetical protein	NA	NA	NA	NA
WP_012605392.1\|244014_244194_+	hypothetical protein	NA	NA	NA	NA
WP_158020049.1\|244226_244448_-	hypothetical protein	NA	NA	NA	NA
WP_080515594.1\|244425_245277_-	phosphoadenosine phosphosulfate reductase family protein	A0A2H4J418	uncultured_Caudovirales_phage	3.0e-56	42.1
WP_012605395.1\|245321_245717_-	hypothetical protein	NA	NA	NA	NA
WP_012605396.1\|245710_246061_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012605397.1\|246064_246496_-	HNH endonuclease	NA	NA	NA	NA
WP_012605398.1\|246492_246702_-	hypothetical protein	NA	NA	NA	NA
WP_012605399.1\|246698_246995_-	hypothetical protein	NA	NA	NA	NA
WP_012605400.1\|246996_247278_-	hypothetical protein	NA	NA	NA	NA
WP_012605401.1\|247284_247803_-	hypothetical protein	NA	NA	NA	NA
WP_012605402.1\|247869_248310_-	hypothetical protein	NA	NA	NA	NA
WP_080515505.1\|248746_249547_-	helix-turn-helix domain-containing protein	R9TRS6	Rhizobium_phage	2.1e-06	24.6
WP_012605404.1\|249527_249776_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012605405.1\|249783_249933_+	hypothetical protein	NA	NA	NA	NA
WP_012605406.1\|249971_250244_-	hypothetical protein	NA	NA	NA	NA
WP_012605407.1\|250429_250678_-	hypothetical protein	NA	NA	NA	NA
WP_012605408.1\|250899_251322_+	hypothetical protein	NA	NA	NA	NA
WP_041928859.1\|251396_251972_+	RusA family crossover junction endodeoxyribonuclease	NA	NA	NA	NA
WP_012605410.1\|251968_252175_+	hypothetical protein	NA	NA	NA	NA
WP_012605411.1\|252171_252399_+	hypothetical protein	NA	NA	NA	NA
WP_158020050.1\|252395_253358_+	hypothetical protein	M4QM11	Sulfitobacter_phage	1.2e-19	43.8
WP_049832661.1\|253257_253950_+	hypothetical protein	NA	NA	NA	NA
WP_012605413.1\|253946_254333_+	hypothetical protein	NA	NA	NA	NA
WP_012605414.1\|254500_254962_+	MucR family transcriptional regulator	A0A1P8VVG0	Erythrobacter_phage	4.8e-24	49.6
WP_012605415.1\|255069_255783_+	hypothetical protein	NA	NA	NA	NA
WP_012605416.1\|255987_258288_-	response regulator	NA	NA	NA	NA
WP_012605417.1\|258517_258781_-	hypothetical protein	NA	NA	NA	NA
WP_012605418.1\|258868_259117_+	WGxxGxxG-CTERM domain-containing protein	NA	NA	NA	NA
WP_012605419.1\|259251_259470_+	hypothetical protein	NA	NA	NA	NA
WP_012605421.1\|260014_260167_+	hypothetical protein	NA	NA	NA	NA
WP_012605422.1\|260292_260931_+	hypothetical protein	NA	NA	NA	NA
WP_012605423.1\|260875_262954_+\|terminase	phage terminase large subunit family protein	A0A2H4JIC6	uncultured_Caudovirales_phage	4.9e-116	40.3
WP_012605424.1\|262957_263212_+	hypothetical protein	NA	NA	NA	NA
WP_158020051.1\|263205_264834_+\|portal	phage portal protein	Q75QM9	Wolbachia_phage	3.2e-107	44.4
WP_012605426.1\|264830_265730_+	S49 family peptidase	A0A219YB02	Aeromonas_phage	5.5e-40	39.5
WP_012605427.1\|265809_266394_+	hypothetical protein	NA	NA	NA	NA
WP_012605428.1\|266396_266777_+\|head	head decoration protein	NA	NA	NA	NA
WP_012605429.1\|266780_267836_+\|capsid	major capsid protein	Q9JMM2	Wolbachia_phage	6.6e-77	45.1
267243:267258	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1069324 : 1127204

Leptospira_phage(25.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003596034.1\|1069324_1070974_-\|transposase	ISL3-like element ISMex10 family transposase	NA	NA	NA	NA
WP_085985480.1\|1071108_1072291_+\|transposase	IS3-like element ISMex5 family transposase	S5WIU1	Leptospira_phage	7.3e-32	32.4
WP_012605994.1\|1072448_1073129_-	sigma-70 family RNA polymerase sigma factor	A0A0F6TH34	Sinorhizobium_phage	1.9e-13	38.7
WP_012605995.1\|1073609_1075199_-	Fic family protein	NA	NA	NA	NA
WP_012753600.1\|1075643_1076126_-	hypothetical protein	NA	NA	NA	NA
WP_012605996.1\|1076427_1076736_+	hypothetical protein	NA	NA	NA	NA
WP_012753603.1\|1078293_1079529_-	carbohydrate porin	NA	NA	NA	NA
WP_012605998.1\|1080385_1080964_+	hypothetical protein	NA	NA	NA	NA
WP_012753604.1\|1080936_1081335_+	hypothetical protein	NA	NA	NA	NA
WP_012606000.1\|1082244_1082979_+	response regulator transcription factor	W8CYM9	Bacillus_phage	2.5e-27	33.8
WP_012606001.1\|1082975_1084310_+	HAMP domain-containing protein	W8CYF6	Bacillus_phage	4.5e-06	33.7
WP_003596692.1\|1084406_1084661_+	hypothetical protein	NA	NA	NA	NA
WP_012606002.1\|1085223_1085415_+	hypothetical protein	NA	NA	NA	NA
WP_131473048.1\|1085443_1085740_+	hypothetical protein	NA	NA	NA	NA
WP_003596689.1\|1085759_1086131_+	hypothetical protein	NA	NA	NA	NA
WP_012606003.1\|1086255_1087620_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_012606004.1\|1087631_1090880_+	CusA/CzcA family heavy metal efflux RND transporter	NA	NA	NA	NA
WP_003596683.1\|1090885_1091440_+	hypothetical protein	NA	NA	NA	NA
WP_012606005.1\|1091485_1092403_+	cation transporter	A0A1V0SED0	Indivirus	6.7e-09	39.3
WP_012606006.1\|1092415_1092586_+	hypothetical protein	NA	NA	NA	NA
WP_003596676.1\|1092908_1093163_+	hypothetical protein	NA	NA	NA	NA
WP_003596674.1\|1093401_1093542_+	hypothetical protein	NA	NA	NA	NA
WP_003596672.1\|1093538_1095083_-	DUF2235 domain-containing protein	NA	NA	NA	NA
WP_012606007.1\|1095285_1096026_-	Abi family protein	NA	NA	NA	NA
WP_085985476.1\|1097274_1098458_-\|transposase	IS3-like element ISMex5 family transposase	S5WIU1	Leptospira_phage	7.3e-32	32.4
WP_003598644.1\|1099220_1099511_+	hypothetical protein	NA	NA	NA	NA
WP_003598646.1\|1099507_1100062_+	hypothetical protein	NA	NA	NA	NA
WP_131473059.1\|1100541_1100967_-	hypothetical protein	NA	NA	NA	NA
WP_003598647.1\|1100963_1101317_-	hypothetical protein	NA	NA	NA	NA
WP_049832675.1\|1101431_1102355_-\|transposase	IS110-like element ISMex31 family transposase	NA	NA	NA	NA
WP_085985055.1\|1103496_1104457_+\|transposase	IS630-like element ISMex30 family transposase	A0A1V0SCG6	Indivirus	7.5e-11	25.5
WP_003598652.1\|1104625_1104793_-	hypothetical protein	NA	NA	NA	NA
WP_041357443.1\|1104867_1105080_-	hypothetical protein	NA	NA	NA	NA
WP_080515519.1\|1105388_1105616_-	cytochrome C biogenesis protein	NA	NA	NA	NA
WP_003598654.1\|1105717_1106791_-	murein L,D-transpeptidase	NA	NA	NA	NA
WP_012753610.1\|1106879_1107401_-	signal peptidase II	NA	NA	NA	NA
WP_003598656.1\|1107397_1109593_-	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	3.2e-118	38.7
WP_003598658.1\|1109693_1110095_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_003598660.1\|1110771_1113192_-	heavy metal translocating P-type ATPase	A0A218MNH6	uncultured_virus	2.9e-67	33.1
WP_003598662.1\|1113259_1113742_-	DUF305 domain-containing protein	A0A218MND9	uncultured_virus	3.9e-08	44.0
WP_003598663.1\|1113796_1114129_-	four-helix bundle copper-binding protein	NA	NA	NA	NA
WP_003598665.1\|1114308_1114707_-	DUF305 domain-containing protein	A0A218MND9	uncultured_virus	6.9e-11	50.7
WP_003598666.1\|1114733_1115099_-	hypothetical protein	NA	NA	NA	NA
WP_003598668.1\|1115118_1118268_-	CusA/CzcA family heavy metal efflux RND transporter	NA	NA	NA	NA
WP_003598670.1\|1118281_1120021_-	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_012606013.1\|1120106_1120577_-	hypothetical protein	NA	NA	NA	NA
WP_003598673.1\|1120668_1120881_-	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_003598674.1\|1121261_1122002_+	NYN domain-containing protein	NA	NA	NA	NA
WP_003598675.1\|1122015_1122492_-	metal-binding protein	NA	NA	NA	NA
WP_003598676.1\|1122511_1125685_-	efflux RND transporter permease subunit	NA	NA	NA	NA
WP_085985478.1\|1126105_1127204_+\|transposase	IS3-like element ISMex11 family transposase	S5WIU1	Leptospira_phage	4.1e-53	43.2

DBSCAN-SWA_4

1603190 : 1670447

Burkholderia_virus(30.0%)

head,tail,portal,protease,capsid,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015950238.1\|1603190_1605308_-\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_085985904.1\|1605849_1606110_+	hypothetical protein	NA	NA	NA	NA
WP_015950239.1\|1606329_1606728_-	cupin domain-containing protein	NA	NA	NA	NA
WP_015950240.1\|1606761_1607508_-	glucose 1-dehydrogenase	Q06VL0	Trichoplusia_ni_ascovirus	4.9e-18	30.4
WP_012252984.1\|1607627_1608542_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_015950241.1\|1608714_1609551_-	3-keto-5-aminohexanoate cleavage protein	NA	NA	NA	NA
WP_015950242.1\|1609719_1610532_+	universal stress protein	A0A2H4J154	uncultured_Caudovirales_phage	5.5e-07	27.8
WP_015950243.1\|1610531_1610858_+	cytochrome c	NA	NA	NA	NA
WP_015950244.1\|1610933_1611686_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_041928958.1\|1612080_1613709_-	ATP-binding cassette domain-containing protein	NA	NA	NA	NA
WP_015950246.1\|1613705_1615349_-	ATP-binding cassette domain-containing protein	NA	NA	NA	NA
WP_015950247.1\|1615448_1617038_+	cytochrome ubiquinol oxidase subunit I	NA	NA	NA	NA
WP_015950248.1\|1617099_1618254_+	cytochrome d ubiquinol oxidase subunit II	NA	NA	NA	NA
WP_003606082.1\|1618323_1618455_+	cytochrome bd-I oxidase subunit CydX	NA	NA	NA	NA
WP_003606080.1\|1618491_1619244_-	DeoR/GlpR transcriptional regulator	A0A077SK06	Escherichia_phage	6.0e-24	32.3
WP_015950249.1\|1619394_1620978_-	amidase	NA	NA	NA	NA
WP_015950250.1\|1621496_1623923_+	response regulator	NA	NA	NA	NA
WP_003606498.1\|1624055_1624868_+	cellulose biosynthesis protein BcsS	NA	NA	NA	NA
WP_015950251.1\|1625196_1627701_+	UDP-forming cellulose synthase catalytic subunit	NA	NA	NA	NA
WP_015950252.1\|1627697_1630340_+	cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB	NA	NA	NA	NA
WP_015950253.1\|1630339_1631629_+	hypothetical protein	NA	NA	NA	NA
WP_041928959.1\|1631613_1633677_+	hypothetical protein	NA	NA	NA	NA
WP_015950255.1\|1633673_1634687_+	cellulose biosynthesis protein BcsN	NA	NA	NA	NA
WP_015950256.1\|1642057_1642321_+	hypothetical protein	NA	NA	NA	NA
WP_015950257.1\|1642413_1642650_+	hypothetical protein	NA	NA	NA	NA
WP_015950258.1\|1642728_1643310_-	hypothetical protein	NA	NA	NA	NA
WP_015950259.1\|1643306_1643606_-	hypothetical protein	NA	NA	NA	NA
WP_015950260.1\|1643620_1644049_-	hypothetical protein	NA	NA	NA	NA
WP_015950261.1\|1644063_1644627_-	hypothetical protein	NA	NA	NA	NA
WP_015950262.1\|1644815_1645514_-	TIGR02594 family protein	H6WBN0	Rhodobacter_phage	5.4e-43	44.2
WP_015950263.1\|1645998_1649217_-	hypothetical protein	NA	NA	NA	NA
WP_015950264.1\|1649332_1649605_-	hypothetical protein	NA	NA	NA	NA
WP_015950265.1\|1649601_1649913_-	hypothetical protein	NA	NA	NA	NA
WP_015950266.1\|1649924_1653914_-	hypothetical protein	NA	NA	NA	NA
WP_015950267.1\|1654532_1654931_-	hypothetical protein	NA	NA	NA	NA
WP_015950268.1\|1654927_1655476_-	DUF1833 family protein	NA	NA	NA	NA
WP_015950269.1\|1655480_1655858_-	hypothetical protein	NA	NA	NA	NA
WP_015950270.1\|1655861_1659719_-\|tail	phage tail length tape measure family protein	A5H1M1	Xanthomonas_virus	3.8e-13	30.8
WP_015950271.1\|1659725_1659986_-	hypothetical protein	NA	NA	NA	NA
WP_015950272.1\|1660060_1660486_-	hypothetical protein	NA	NA	NA	NA
WP_015950273.1\|1660482_1660677_-	hypothetical protein	NA	NA	NA	NA
WP_015950274.1\|1660673_1661606_-	hypothetical protein	A0A0S0N8B7	Pseudomonas_phage	1.3e-36	35.1
WP_015950275.1\|1661644_1662055_-	hypothetical protein	NA	NA	NA	NA
WP_015950276.1\|1662056_1662740_-	hypothetical protein	NA	NA	NA	NA
WP_015950277.1\|1662739_1663066_-	hypothetical protein	NA	NA	NA	NA
WP_015950278.1\|1663062_1663743_-	hypothetical protein	NA	NA	NA	NA
WP_080515597.1\|1663739_1664495_-	collagen-like protein	NA	NA	NA	NA
WP_015950281.1\|1664575_1665082_-	hypothetical protein	NA	NA	NA	NA
WP_015950282.1\|1665087_1665348_-	hypothetical protein	NA	NA	NA	NA
WP_193373772.1\|1665411_1666707_-\|capsid	phage major capsid protein	Q6JIM7	Burkholderia_virus	5.9e-136	63.9
WP_041929213.1\|1666724_1667420_-\|head,protease	HK97 family phage prohead protease	Q6JIM8	Burkholderia_virus	6.5e-65	65.4
WP_015950285.1\|1667449_1668754_-\|portal	phage portal protein	Q6JIM9	Burkholderia_virus	1.7e-95	46.6
WP_015950286.1\|1668773_1670447_-\|terminase	terminase large subunit	S4TSQ6	Salmonella_phage	3.8e-135	46.2

DBSCAN-SWA_5

1692506 : 1753139

Paracoccus_phage(27.27%)

protease,head,tail,integrase

attL 1687908:1687923|attR 1706349:1706364

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1687908:1687923	attL	NA	NA	NA	NA
WP_041928965.1\|1692506_1693679_+\|integrase	site-specific integrase	A0A076G7B8	Sinorhizobium_phage	3.4e-66	38.9
WP_041928966.1\|1694403_1694778_+	toprim domain-containing protein	A0A060BKV1	Podovirus	3.8e-19	42.3
WP_158020072.1\|1694811_1695207_+	hypothetical protein	NA	NA	NA	NA
WP_015822017.1\|1695538_1696309_-	anti-sigma factor	NA	NA	NA	NA
WP_015950331.1\|1696394_1696958_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_012253006.1\|1697195_1698500_-	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_015950332.1\|1698784_1699198_+	hypothetical protein	NA	NA	NA	NA
WP_015950333.1\|1699247_1700321_+	DUF1775 domain-containing protein	NA	NA	NA	NA
WP_015950334.1\|1700436_1700961_+	copper chaperone PCu(A)C	NA	NA	NA	NA
WP_015950335.1\|1700950_1701598_+	SCO family protein	NA	NA	NA	NA
WP_015950336.1\|1701740_1702097_+	hypothetical protein	NA	NA	NA	NA
WP_015950337.1\|1702139_1704287_+	TonB-dependent receptor	NA	NA	NA	NA
WP_015950338.1\|1704531_1706379_+	caspase family protein	NA	NA	NA	NA
1706349:1706364	attR	NA	NA	NA	NA
WP_015950339.1\|1706529_1708002_-	carbohydrate porin	NA	NA	NA	NA
WP_012752438.1\|1708106_1708766_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_015950340.1\|1708941_1709964_+	TRAP transporter substrate-binding protein DctP	NA	NA	NA	NA
WP_015950341.1\|1709960_1710686_+	TRAP transporter small permease	NA	NA	NA	NA
WP_012253016.1\|1710682_1712035_+	TRAP transporter large permease	NA	NA	NA	NA
WP_015950342.1\|1712202_1712400_+	hypothetical protein	NA	NA	NA	NA
WP_015950343.1\|1713192_1713426_+	hypothetical protein	NA	NA	NA	NA
WP_015950344.1\|1713493_1714540_+	cysteine synthase A	A0A1X9I5K7	Streptococcus_phage	2.8e-43	36.4
WP_003603329.1\|1714652_1714808_+	hypothetical protein	NA	NA	NA	NA
WP_041929221.1\|1714823_1716314_-	trypsin-like peptidase domain-containing protein	NA	NA	NA	NA
WP_041928968.1\|1716493_1716940_+	DMT family transporter	NA	NA	NA	NA
WP_015950347.1\|1717052_1722371_+	alpha-2-macroglobulin family protein	NA	NA	NA	NA
WP_015950348.1\|1722375_1724577_+	penicillin-binding protein 1C	NA	NA	NA	NA
WP_003607143.1\|1724714_1725035_+	quaternary ammonium compound efflux SMR transporter SugE	NA	NA	NA	NA
WP_015950349.1\|1725039_1725840_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_015950350.1\|1725891_1726515_-	class GN sortase	NA	NA	NA	NA
WP_015950351.1\|1726511_1728728_-	marine proteobacterial sortase target protein	A0A2K9L1L0	Tupanvirus	4.1e-12	21.1
WP_015950352.1\|1728972_1729584_+	histidine phosphatase family protein	NA	NA	NA	NA
WP_041929222.1\|1729671_1730412_-	hypothetical protein	NA	NA	NA	NA
WP_015950354.1\|1730522_1731536_-	nickel transporter	NA	NA	NA	NA
WP_015950355.1\|1731526_1732204_-	DUF1007 family protein	NA	NA	NA	NA
WP_015950356.1\|1732318_1732780_-	cytochrome c-type biogenesis protein CcmH	NA	NA	NA	NA
WP_015950357.1\|1732776_1734777_-	heme lyase CcmF/NrfE family subunit	NA	NA	NA	NA
WP_015950358.1\|1734823_1735345_-	cytochrome c maturation protein CcmE	NA	NA	NA	NA
WP_015950359.1\|1735507_1737079_-	c-type cytochrome biogenesis protein CcmI	NA	NA	NA	NA
WP_003606556.1\|1737225_1738641_-	hypothetical protein	NA	NA	NA	NA
WP_003606557.1\|1739027_1739705_-	response regulator transcription factor	NA	NA	NA	NA
WP_015950360.1\|1739743_1740283_-	hypothetical protein	NA	NA	NA	NA
WP_015950361.1\|1740296_1740545_-	hypothetical protein	NA	NA	NA	NA
WP_012253038.1\|1740567_1740921_-	hypothetical protein	NA	NA	NA	NA
WP_015950362.1\|1740970_1741573_-	hypothetical protein	NA	NA	NA	NA
WP_015950363.1\|1741606_1742170_-	lysozyme	W6E9Q2	Rhizobium_phage	6.3e-26	38.7
WP_015950364.1\|1742288_1743371_-	DUF2793 domain-containing protein	A0A0K1LM04	Rhodobacter_phage	2.4e-37	40.2
WP_015950365.1\|1743395_1747304_-	glycoside hydrolase TIM-barrel-like domain-containing protein	A0A0B5A7K5	Paracoccus_phage	1.3e-191	35.7
WP_015950366.1\|1747343_1747808_-	C40 family peptidase	A0A1V0DYB6	Dinoroseobacter_phage	2.9e-29	46.8
WP_015950367.1\|1747815_1748709_-	DUF2163 domain-containing protein	A0A0B5A5B8	Paracoccus_phage	5.1e-62	42.7
WP_015950368.1\|1748719_1749361_-	DUF2460 domain-containing protein	A0A0B5A2K3	Paracoccus_phage	1.4e-45	49.5
WP_015950369.1\|1749372_1749999_-\|tail	phage tail tape measure protein	G9JXH3	Shigella_phage	2.5e-07	69.0
WP_015950370.1\|1749998_1750229_-\|tail	phage tail assembly chaperone	NA	NA	NA	NA
WP_041929223.1\|1750225_1750552_-	gene transfer agent family protein	NA	NA	NA	NA
WP_015950372.1\|1750554_1750965_-\|tail	phage major tail protein, TP901-1 family	NA	NA	NA	NA
WP_041928971.1\|1750994_1751414_-	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_015950374.1\|1751410_1751752_-\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_015950375.1\|1751774_1752350_-	phiE125 gp8 family protein	NA	NA	NA	NA
WP_015950376.1\|1752383_1753139_+\|protease	trypsin-like serine protease	NA	NA	NA	NA

DBSCAN-SWA_6

4459710 : 4486431

Bodo_saltans_virus(100.0%)

integrase,tRNA,protease,transposase

attL 4477779:4477796|attR 4501489:4501506

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_193373782.1\|4459710_4460660_-\|transposase	IS630 family transposase	A0A2H4UV16	Bodo_saltans_virus	6.9e-09	25.4
WP_015952150.1\|4461543_4462032_+	hypothetical protein	NA	NA	NA	NA
WP_041929084.1\|4462190_4463993_+	cellulase family glycosylhydrolase	NA	NA	NA	NA
WP_015952152.1\|4464709_4465372_-	sugar transferase	NA	NA	NA	NA
WP_158020129.1\|4465972_4466518_+\|transposase	transposase	NA	NA	NA	NA
WP_162091623.1\|4468063_4469305_-	hypothetical protein	NA	NA	NA	NA
WP_158020130.1\|4470560_4470881_-\|transposase	transposase	NA	NA	NA	NA
WP_015952154.1\|4472137_4473457_-	lipopolysaccharide biosynthesis protein	NA	NA	NA	NA
WP_162091624.1\|4473482_4474679_-	glycosyltransferase	NA	NA	NA	NA
WP_015952156.1\|4474724_4475846_-	DUF1972 domain-containing protein	NA	NA	NA	NA
WP_158020131.1\|4475915_4477148_-	glycosyltransferase	NA	NA	NA	NA
4477779:4477796	attL	NA	NA	NA	NA
WP_080515576.1\|4477935_4478457_+\|transposase	transposase	NA	NA	NA	NA
WP_158020132.1\|4479315_4479483_+	hypothetical protein	NA	NA	NA	NA
WP_080515577.1\|4479508_4480132_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_041929319.1\|4481037_4481259_-	hypothetical protein	NA	NA	NA	NA
WP_015952160.1\|4482077_4483502_-\|tRNA	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	NA	NA	NA	NA
WP_015952161.1\|4483795_4485418_+	calcium-binding protein	NA	NA	NA	NA
WP_003599551.1\|4485456_4486431_-\|protease	serine protease	NA	NA	NA	NA
4501489:4501506	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_011758

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_011757

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection