CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_012483	Acidobacterium capsulatum ATCC 51196, complete sequence	6 crisprs	cas1,cas4,cas7b,cas8c,cas5,cas3,csa3,DinG,RT	0	5	1	0

1. NC_012483

CRISPR-Cas detection and classification

Crispr_ID: NC_012483_1

• CRISPR_ID: NC_012483_1
• CRISPR_location: 894165-895723
• CRISPR_type: TypeI
• Repeat_type: I-C
• Spacer_info: 23 spacers
• Cas_protein_info: cas2,cas1,cas4,cas7b,cas8c,cas5,cas3

Consensus repeat of NC_012483_1

Consensus_repeat	Method
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	PILER-CR
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CRISPRCasFinder
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CRT

spacers of NC_012483_1

>1.1|894197|37|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GGCGGCTGGCAGCGATGGCCGAGTTATTGTTGTTCGT
>1.2|894266|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GGTTTCGATGCCCTATTTGCTGCGATGGGGAGATG
>1.3|894333|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT
CGTGCCACTGAGATCGAGAGAGCCTTCCACGCTCA
>1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GTGTCAGTGTAGCCGCTGCCGCCGTTGGTGATCGA
>1.5|894467|34|NC_012483|PILER-CR,CRISPRCasFinder,CRT
AAAATGCGGCTGAACGTTCTCGAGGCCAACAGCG
>1.6|894533|34|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GTTGGTCGCTGCTCCGGTTGGCGATGAAGTGTTG
>1.7|894599|34|NC_012483|PILER-CR,CRISPRCasFinder,CRT
ATGGATGTAGATGTCCGAAGCATTCGCACAAGTG
>1.8|894665|34|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GGGTGTCAGCGGCGAAGTTGAGACCATCGGCCGT
>1.9|894731|33|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GGCGGTTTGGCCGATCTGCGCATTGGCCGGCAA
>1.10|894796|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GAAACAGTCGGGTTCGAAGTGCATGCGCCATTCGT
>1.11|894863|33|NC_012483|PILER-CR,CRISPRCasFinder,CRT
CGTGATGGATCAAAGTCCCCACGCGCTACGCGA
>1.12|894928|34|NC_012483|PILER-CR,CRISPRCasFinder,CRT
TGCGCTGAACTGCTGAGTCCCGGACGCCAAGATC
>1.13|894994|34|NC_012483|PILER-CR,CRISPRCasFinder,CRT
CAACCCTGTAAGGATGTTTAACGTCATCGAAATA
>1.14|895060|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GGTATTCGACGAGGGCAGAAGCCTGGCTCACTCCG
>1.15|895127|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GACAAGCTGCTGGTGGTACTGTGAGGGGTTTCATC
>1.16|895194|33|NC_012483|PILER-CR,CRISPRCasFinder,CRT
CAGATAAAATCGTCGTCGCCCCGAGGCACACGC
>1.17|895259|33|NC_012483|PILER-CR,CRISPRCasFinder,CRT
TGTGGTCCAGCTGTTGCCGGAGCCGTCCTGGAA
>1.18|895324|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GTTGCCGGTGTGGCTGAATTTGATTGGTTCAGGAG
>1.19|895391|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GTTCGGGTCCTCCACAACCTTGATGCCATCGGCCA
>1.20|895458|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTT
>1.21|895525|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTT
>1.22|895592|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT
GTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTT
>1.23|895659|33|NC_012483|PILER-CR,CRISPRCasFinder,CRT
TGTGGCTACCAGGCTCACAGCCGTGTGGCGGTT

CRISPR arrays and Neighbor proteins around NC_012483_1

CRISPR arrays

The CRISPR arrays of NC_012483_1

>merge|NC_012483|1|894165-895723|PILER-CR,CRISPRCasFinder,CRT
GTTTCGATCCACGCGTCCGCGAGGGGCGCGACGGCGGCTGGCAGCGATGGCCGAGTTATTGTTGTTCGTGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGGTTTCGATGCCCTATTTGCTGCGATGGGGAGATGGTTTCAATCCACGCGCCCGCGAGGGGCGCGACCGTGCCACTGAGATCGAGAGAGCCTTCCACGCTCAGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGTGTCAGTGTAGCCGCTGCCGCCGTTGGTGATCGAGTTTCAATCCACGCGCCCGCGAGGGGCGCGACAAAATGCGGCTGAACGTTCTCGAGGCCAACAGCGGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGTTGGTCGCTGCTCCGGTTGGCGATGAAGTGTTGGTTTCAATCCACGCGCCCGCGAGGGGCGCGACATGGATGTAGATGTCCGAAGCATTCGCACAAGTGGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGGGTGTCAGCGGCGAAGTTGAGACCATCGGCCGTGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGGCGGTTTGGCCGATCTGCGCATTGGCCGGCAAGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGAAACAGTCGGGTTCGAAGTGCATGCGCCATTCGTGTTTCAATCCACGCGCCCGCGAGGGGCGCGACCGTGATGGATCAAAGTCCCCACGCGCTACGCGAGTTTCAATCCACGCGCCCGCGAGGGGCGCGACTGCGCTGAACTGCTGAGTCCCGGACGCCAAGATCGTTTCAATCCACGCGCCCGCGAGGGGCGCGACCAACCCTGTAAGGATGTTTAACGTCATCGAAATAGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGGTATTCGACGAGGGCAGAAGCCTGGCTCACTCCGGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGACAAGCTGCTGGTGGTACTGTGAGGGGTTTCATCGTTTCAATCCACGCGCCCGCGAGGGGCGCGACCAGATAAAATCGTCGTCGCCCCGAGGCACACGCGTTTCAATCCACGCGCCCGCGAGGGGCGCGACTGTGGTCCAGCTGTTGCCGGAGCCGTCCTGGAAGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGTTGCCGGTGTGGCTGAATTTGATTGGTTCAGGAGGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGTTCGGGTCCTCCACAACCTTGATGCCATCGGCCAGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTTGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTTGTTTCAATCCACGCGCCCGCGAGGGGCGCGACGTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTTGTTTCAATCCACGCGCCCGCGAGGGGCGCGACTGTGGCTACCAGGCTCACAGCCGTGTGGCGGTTGTTTCAATCCACGCGCCCGCGAGGGGCGCGAC

>NC_012483|1|1|894165-895723|PILER-CR
GTTTCGATCCACGCGTCCGCGAGGGGCGCGAC	GGCGGCTGGCAGCGATGGCCGAGTTATTGTTGTTCGT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GGTTTCGATGCCCTATTTGCTGCGATGGGGAGATG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CGTGCCACTGAGATCGAGAGAGCCTTCCACGCTCA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTGTCAGTGTAGCCGCTGCCGCCGTTGGTGATCGA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	AAAATGCGGCTGAACGTTCTCGAGGCCAACAGCG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTTGGTCGCTGCTCCGGTTGGCGATGAAGTGTTG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	ATGGATGTAGATGTCCGAAGCATTCGCACAAGTG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GGGTGTCAGCGGCGAAGTTGAGACCATCGGCCGT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GGCGGTTTGGCCGATCTGCGCATTGGCCGGCAA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GAAACAGTCGGGTTCGAAGTGCATGCGCCATTCGT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CGTGATGGATCAAAGTCCCCACGCGCTACGCGA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	TGCGCTGAACTGCTGAGTCCCGGACGCCAAGATC
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CAACCCTGTAAGGATGTTTAACGTCATCGAAATA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GGTATTCGACGAGGGCAGAAGCCTGGCTCACTCCG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GACAAGCTGCTGGTGGTACTGTGAGGGGTTTCATC
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CAGATAAAATCGTCGTCGCCCCGAGGCACACGC
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	TGTGGTCCAGCTGTTGCCGGAGCCGTCCTGGAA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTTGCCGGTGTGGCTGAATTTGATTGGTTCAGGAG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTTCGGGTCCTCCACAACCTTGATGCCATCGGCCA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	TGTGGCTACCAGGCTCACAGCCGTGTGGCGGTT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC

>NC_012483|1|1|894165-895723|CRISPRCasFinder
GTTTCGATCCACGCGTCCGCGAGGGGCGCGAC	GGCGGCTGGCAGCGATGGCCGAGTTATTGTTGTTCGT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GGTTTCGATGCCCTATTTGCTGCGATGGGGAGATG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CGTGCCACTGAGATCGAGAGAGCCTTCCACGCTCA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTGTCAGTGTAGCCGCTGCCGCCGTTGGTGATCGA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	AAAATGCGGCTGAACGTTCTCGAGGCCAACAGCG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTTGGTCGCTGCTCCGGTTGGCGATGAAGTGTTG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	ATGGATGTAGATGTCCGAAGCATTCGCACAAGTG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GGGTGTCAGCGGCGAAGTTGAGACCATCGGCCGT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GGCGGTTTGGCCGATCTGCGCATTGGCCGGCAA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GAAACAGTCGGGTTCGAAGTGCATGCGCCATTCGT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CGTGATGGATCAAAGTCCCCACGCGCTACGCGA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	TGCGCTGAACTGCTGAGTCCCGGACGCCAAGATC
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CAACCCTGTAAGGATGTTTAACGTCATCGAAATA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GGTATTCGACGAGGGCAGAAGCCTGGCTCACTCCG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GACAAGCTGCTGGTGGTACTGTGAGGGGTTTCATC
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CAGATAAAATCGTCGTCGCCCCGAGGCACACGC
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	TGTGGTCCAGCTGTTGCCGGAGCCGTCCTGGAA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTTGCCGGTGTGGCTGAATTTGATTGGTTCAGGAG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTTCGGGTCCTCCACAACCTTGATGCCATCGGCCA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	TGTGGCTACCAGGCTCACAGCCGTGTGGCGGTT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC

>NC_012483|1|1|894165-895723|CRT
GTTTCGATCCACGCGTCCGCGAGGGGCGCGAC	GGCGGCTGGCAGCGATGGCCGAGTTATTGTTGTTCGT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GGTTTCGATGCCCTATTTGCTGCGATGGGGAGATG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CGTGCCACTGAGATCGAGAGAGCCTTCCACGCTCA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTGTCAGTGTAGCCGCTGCCGCCGTTGGTGATCGA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	AAAATGCGGCTGAACGTTCTCGAGGCCAACAGCG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTTGGTCGCTGCTCCGGTTGGCGATGAAGTGTTG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	ATGGATGTAGATGTCCGAAGCATTCGCACAAGTG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GGGTGTCAGCGGCGAAGTTGAGACCATCGGCCGT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GGCGGTTTGGCCGATCTGCGCATTGGCCGGCAA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GAAACAGTCGGGTTCGAAGTGCATGCGCCATTCGT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CGTGATGGATCAAAGTCCCCACGCGCTACGCGA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	TGCGCTGAACTGCTGAGTCCCGGACGCCAAGATC
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CAACCCTGTAAGGATGTTTAACGTCATCGAAATA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GGTATTCGACGAGGGCAGAAGCCTGGCTCACTCCG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GACAAGCTGCTGGTGGTACTGTGAGGGGTTTCATC
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	CAGATAAAATCGTCGTCGCCCCGAGGCACACGC
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	TGTGGTCCAGCTGTTGCCGGAGCCGTCCTGGAA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTTGCCGGTGTGGCTGAATTTGATTGGTTCAGGAG
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTTCGGGTCCTCCACAACCTTGATGCCATCGGCCA
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	GTGTGTTGATCGGCTGGCTGCCTTCCCCGGCGGTT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC	TGTGGCTACCAGGCTCACAGCCGTGTGGCGGTT
GTTTCAATCCACGCGCCCGCGAGGGGCGCGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_012483.1|WP_015895953.1|901448_901649_-|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_015895957.1|908796_909858_-|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NC_012483.1|WP_015895939.1|879998_880436_+|universal-stress-protein	unknown	unknown	gnl|CDD|238182
NC_012483.1|WP_052294668.1|897238_897874_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|187768
NC_012483.1|WP_015895947.1|895883_896177_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_012483.1|WP_015895937.1|877425_878598_+|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_015895936.1|876287_877274_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl|CDD|224936
NC_012483.1|WP_015895940.1|881176_881641_-|DUF4126-family-protein	unknown	unknown	gnl|CDD|226432
NC_012483.1|WP_015895945.1|886430_889838_-|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl|CDD|379297
NC_012483.1|WP_015895946.1|890466_893877_+|discoidin-domain-containing-protein	unknown	unknown	gnl|CDD|375009
NC_012483.1|WP_015895948.1|896210_897242_-|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl|CDD|188360
NC_012483.1|WP_015895954.1|901814_904130_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl|CDD|350688
NC_012483.1|WP_015895956.1|907256_908711_+|D-xylose-transporter-XylE	unknown	unknown	gnl|CDD|182225
NC_012483.1|WP_169305906.1|883284_883761_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|370445
NC_012483.1|WP_148215012.1|883799_886337_-|family-78-glycoside-hydrolase-catalytic-domain	unknown	unknown	gnl|CDD|379971
NC_012483.1|WP_148215011.1|878766_879741_+|class-II-aldolase/adducin-family-protein	unknown	unknown	gnl|CDD|376358
NC_012483.1|WP_015895950.1|897946_898858_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_012483.1|WP_015895941.1|881764_882343_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_012483.1|WP_015895951.1|898854_900711_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	gnl|CDD|273839
NC_012483.1|WP_015895952.1|900692_901418_-|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	gnl|CDD|187534

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_012483.1|WP_015895948.1|896210_897242_-|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	5.4e-149	490.5	0.1
NC_012483.1|WP_015895954.1|901814_904130_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	2.1e-51	169.7	0.0
NC_012483.1|WP_015895952.1|900692_901418_-|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	1.9e-53	176.0	0.0
NC_012483.1|WP_015895947.1|895883_896177_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1e-26	87.7	0.1
NC_012483.1|WP_015895950.1|897946_898858_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	1.8e-93	307.6	0.0
NC_012483.1|WP_052294668.1|897238_897874_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	3.7e-26	86.9	0.0
NC_012483.1|WP_015895951.1|898854_900711_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	3.2e-172	568.7	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_012483.1|WP_015895957.1|908796_909858_-|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.42189e-96
NC_012483.1|WP_015895939.1|879998_880436_+|universal-stress-protein	gnl|CDD|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	1.78022e-19
NC_012483.1|WP_052294668.1|897238_897874_-|CRISPR-associated-protein-Cas4	gnl|CDD|187768	cd09637, Cas4_I-A_I-B_I-C_I-D_II-B, CRISPR/Cas system-associated protein Cas4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster.	2.62633e-25
NC_012483.1|WP_015895947.1|895883_896177_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	9.79308e-29
NC_012483.1|WP_169305906.1|883284_883761_-|helix-turn-helix-domain-containing-protein	gnl|CDD|370445	pfam09339, HTH_IclR, IclR helix-turn-helix domain.	2.23e-10
NC_012483.1|WP_015895936.1|876287_877274_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl|CDD|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	5.10089e-107
NC_012483.1|WP_015895940.1|881176_881641_-|DUF4126-family-protein	gnl|CDD|226432	COG3918, COG3918, Predicted membrane protein [Function unknown].	3.16209e-37
NC_012483.1|WP_015895945.1|886430_889838_-|carboxypeptidase-regulatory-like-domain-containing-protein	gnl|CDD|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	5.31246e-21
NC_012483.1|WP_015895946.1|890466_893877_+|discoidin-domain-containing-protein	gnl|CDD|375009	pfam17132, Glyco_hydro_106, alpha-L-rhamnosidase.	0
NC_012483.1|WP_015895948.1|896210_897242_-|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl|CDD|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NC_012483.1|WP_015895954.1|901814_904130_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	4.57792e-50
NC_012483.1|WP_015895952.1|900692_901418_-|type-I-C-CRISPR-associated-protein-Cas5	gnl|CDD|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	2.18528e-62
NC_012483.1|WP_148215012.1|883799_886337_-|family-78-glycoside-hydrolase-catalytic-domain	gnl|CDD|379971	pfam17389, Bac_rhamnosid6H, Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain. This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.	2.0369e-17
NC_012483.1|WP_148215011.1|878766_879741_+|class-II-aldolase/adducin-family-protein	gnl|CDD|376358	pfam00596, Aldolase_II, Class II Aldolase and Adducin N-terminal domain. This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.	1.21979e-49
NC_012483.1|WP_015895950.1|897946_898858_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	7.15834e-131
NC_012483.1|WP_015895941.1|881764_882343_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.66343e-12
NC_012483.1|WP_015895951.1|898854_900711_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl|CDD|273839	TIGR01863, CRISPR-associated_protein_CT1133_family, CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein that tends to be found near CRISPR repeats of the DVULG subtype of CRISPR/Cas locus. We designate this family Csd1 (CRISPR/Cas Subtype DVULG protein 1). The species range for this subtype, so far, is exclusively bacterial and mesophilic, although CRISPR loci in general are particularly common among archaea and thermophilic bacteria. In a few species (Xanthomonas axonopodis pv. citri str. 306 and Streptococcus mutans UA159), homology to this protein family is split across two tandem genes; the trusted cutoff to this family is set low enough to capture at least the longer of the two.	0
NC_012483.1|WP_015895956.1|907256_908711_+|D-xylose-transporter-XylE	gnl|CDD|182225	PRK10077, xylE, D-xylose transporter XylE; Provisional.	0

Protein sequences

>NC_012483.1|WP_015895946.1|890466_893877_+|discoidin-domain-containing-protein
MHRSQLVVAAAAMLFIPVFAHAQSPATASASTPATLRSGFSTPPESARPRVWWHWMNGNISRQGIRLDLQWMHSIGLGGVTTIDASLSTPQVVKQRVVYMTPAWRSDFLYATRLLEQFDMKESIDSSPGWSETGGPWVRPSQGMKKYVWSTIVVQGGRRFDQKLPHPPSETGAFQDETIHDVLGSSSGDRTIPHYYEDSVVVAYRIPADDVPLASLHPQITASGGHPDYALLTDGNLTRTTSLAIPPQGQDAWIRYAFSHPVTIRAITLVTQNPDRIVSMIYGIAAPKKVLEASDNGQTWRTVARLDTGDSPETTISFAPVTARYFRVTFHRGIAPPPPAWAKGVDPRSFGLKAETAPTGYKIAELVLHTGARVNHFEQKAAFVPTAGLDRFPTPAYASDAAVRPADVIDLTSKVKTDGTLDWTPPPGRWAILRFGYSLLGITNHPATIESTGLEVDKLNGNDVHQYMEAYLDSYKSAVGAANMGARGITSVTNDSWEAGSENWTGDMIQQFRKLRGYNPIPWMPVLTGVVVGSPAQSDRFLWDFRQTIGDLIATQHFGVIQKVLDQWHLTHYCESDESGRAFVADGMRVKKHCQVPMGAMWTQTLSTNNVQYNYNADDRESASVAHIYGQNLTAAESMTAAADPWAWSPATLKPTADQEFLNGINRFFIHESAHQPLLNKKPGLTLGPFGQWFNRNETWAGEASPWIRYLARNSYMLQQGRFAADILYYYGQDTNLTALYHDRSPNLPNGYDFDYADADALLHVLGVNAAGEITTPGKVTYRILGLNQNSRHMSLPVLEAIHRLVMQGATVAGPKPTSDPSLSDDQAQFHALADQLFGDGTGIHHLGKGTVYAGSTVAEALVAMQAAPDFDCIPTVPGANVKFIHRKLPDGDIYFLDNRSDAPATVEASFRVDGRIPALWHSDTGSIDSVSYTIANGRTTLPLHFAPWGTVFVVFRGHTTKHSWTAPARDTEQLATLHGPWKVNFPPDWGAPPSITLDTLASWSDNPDSGVKYFSGTGTYTRTLQAPASWFRHGAHIWINLGVVRNLAEVSVNGESLGIVWHTPYRLDATSALHPGSNTLTIRVTNAWANRIIGDQQPNAAKKYTFTDYHPYHANSPLQPSGLLGPVTVDSVTTR
>NC_012483.1|WP_015895945.1|886430_889838_-|carboxypeptidase-regulatory-like-domain-containing-protein
MQAQTIRNLLLVVLLVVSLSTLRANAQANLGAISGTVTDPTGAAVPGATVVVTNTSTGIAKTLTTNADGYYSAEDLDAGQYTVKVTDQGFQAAVFSNLQLSPGQRLANNAMLKVGNVSSQVVVNANALQVNTQTSESGGTISSKQISNLMLNGRNFQTLGISIPGVSSTAGADSLNGGGLEGGTTLIVNGQSTEYTTYTIDGVYNMNSGNLSNINILPIVDAISQFSVLKDNYSAQYGFAGSGQIVVQTKAGGREFHGDAWDFLRNSAFDANNYFSTSKEPLHQNIFGYTLGGPVVIPGVYNTRRNRKTFFFASNQWYVISAGQVSRGSVFTDAMRNGDFSASPTLPSSKALAIDAHSQALLASEGKTGCLTGPTTINPTCFDPVAASLIQTYMPQPNNQAGGFLNYVNGNPLTTSQVDYVYRLDQQLPMKTQLTGRIMYEQVKNGFPYDTWGGMPYTTTTDSYYTTAFNGLIRLQSTVTPNLMNTVSLAETYDKPRINTLTGGKLPSGVSIQQQFPNAPTLGRMPNVSISSGWSGFGVSSEPITASDGEGVIQDDLNWVHGKQVIQAGLLYMFGIKRQNVFTNPQGSFTFTGVHTGDPAADFLLGLDNSYSQASSQKLGSYHYRQGAWYVQDDWNVMPRLTLNMGVRWVYFSNDTVSGDEVTTFNPALYDASQAPVVNVDGSLQVNAQNEPVTSSGTVANLLNGLEFAGKNGVPSGFFIPKKTNFAPRVGFAYDVFGNGKTSVRGGYGIGYSRIPLEQIYNAFGQNPPFNQSANILNSLLSNGTAGTQAAPTTQTLDNVPLNFTPSQIQTYSLTLEQQIIPNMIASVAYTGSLGRHLMTYQGGYDFNFPLPVTAPSTSGCLAAGQAASSRYDFDPCINVGLASEDYTRPYKGYSTMNNEYDEGSSNYNSLQSSLRYRTNNLQLTVAYTYQKTLGTIGAHGAGSAGSQSTPAQNPRNFHAEYGPPSYDFTNDLTATWVYRIPIFDHSGHAMQALLGDWSFSGLALHQSGFAMSPGMGTTTRGLAIRPDQVKAYSKVGRLNEWFNTTDFAAPAYGFFGDARNGTIRGPAYTSLNVALQKTWPLVSRLHAQFRAEAFNVANHPNFRSVDTGVGDGSYGQVTNAGDPRILEFSLKLVY
>NC_012483.1|WP_148215012.1|883799_886337_-|family-78-glycoside-hydrolase-catalytic-domain
MGRRQRIVFLMALLGSGCMAVAQMGNPANGPTKIPDADLDPARNLAQSQLESALHQPLPEHYIWTKADVLPGRENLATPASRMGGEDLGPHYFRRAFNVGSLPEHATLYVAGPREARIYVNGKKVGEFALNLDIPIGIRVYACDVTGALRSGKNVVAIEAERGPDATNQNEDWISRQQSFGRVLAAMIVPAARGVQAPPLVMSDGRWKATLQAQPKDWEMPEFDDSGWSAVNDLGGIESSIDLFQGNADAGMYAWPGYDGISPFLAHYNLRAVKVSHVYRGVGKIDGAQSLGGNATNTALTVTLPTQEVPLQDAPQLLLDFGREVTGRIELQSASDSPAQVVVQYGESEEEAIKQPYLGADPIYLPPHGTAFGPKSAFRYAVVRFTGGRETRFRSIRLDGIAYPVKYQGSFESSDAELNKMWAIGAYTAHLCMQDDIWDAPKRDRRRWIGDLDVSGRTIDDVFGDHFLMEDTLSRLIGAAPVEQHVNEIPGYSAFWITAETEYYLHFGSMKQLESVHSRMVQLLDYMAKDLNQQNLFSDLSHAWPFVDWSPGMNGYDAQTRMATQFEYYAAFKDGAYLLHILHDKNNASRMEAKAHALMAAAQHSMLDAQGSFGSRWQPNAYAVLSGVAGKDQYAAIWKNALADVGREEYHPYIITPYYNFYVVSAMAKMGHPDVALRWIRKYWGGMVQEGATSYWEGYDPTWYKGMDFHESLQADNMSGFAVSLAHGWSSGVTPWLMAQMLGIEPTAGGFSKVSIRPDLMGLKWARGSEPTPHGLLKVSIRNSDGYVTAIDLPAGVEAQVAVPVGTNGAGLKVNGKPMPSIAAGGGRRMVELRGEGHYVVTGAS
>NC_012483.1|WP_169305906.1|883284_883761_-|helix-turn-helix-domain-containing-protein
MKGQLRQRQGVFELASRAWKKELLEEGKPLFRRKGICELAPAGADEQVAGNTARTYIIPVLSKALTILELIKGSERPVSAREIHDLLGYPQATVYRILRTLLVHGVIEKGSGMMRAPADRGQPATESRHGTADDKLGGAKLKCFKVKRIRTTRYRAGK
>NC_012483.1|WP_015895941.1|881764_882343_-|TetR/AcrR-family-transcriptional-regulator
MDNNTAVRIRETAHDLIAERGYFGFSYADIANVVGIRKASIHHHFPSKIDLVVATLKQYRAKLAEAAGGLDRNMADPLQRIKLYLQYWAECVKSNNRPICIAALLSTELPALPEEIQTEVQLHFKYLVSWIRATLNEGSRRGDIHLEQTAEVEAQSFVALVHGAMISARALGSPAVFTSITKGALERFHPSK
>NC_012483.1|WP_015895940.1|881176_881641_-|DUF4126-family-protein
MSFLIAAFVLGVACGLRALVGLAAVSWAASGQHLPLQGTWVSFLGNRITSYISSVLAIGEIINDKFPKTPSRLVPPQFGARIVIGALTGSAIGLSQGNPVMGALVGIIGSVVGTLAGAKGRALAAKLFGRDLPAALLEDVLAVALAFVAIAMLR
>NC_012483.1|WP_015895939.1|879998_880436_+|universal-stress-protein
MFQRILIAYDGSPESKKALETGIALARELKADTSLVSVIEPLPGYIALAGSVEPSYPAELIREHREKLGAMQAEVKQKAAQSGMEIDTLLVEAGEAEGVLEAVRETQAGLLVVGLRPHDHTVEFAGTLRRIANQIHCPVLAVPCH
>NC_012483.1|WP_148215011.1|878766_879741_+|class-II-aldolase/adducin-family-protein
MEVVMQKSQSEHIADLLRETIERCLAAGHAQGAPGGFDDLFHAPETAALKEEVVRAGRKLWERQYVDGNGGNISVRLPGDMILCTPTMMSKGDLRADELCLVDLDNKLLCGCRPQTSEILLHLEIYKAVPEARAVIHCHPPYATAHALAGVVPPGNLLSEQEIFIGPVALAPYETPGTPAFAATVLPYVRNHNTILLAHHGIVCWADTVTHAEWYTEVIETYCKTVMIARQLQPNLEEIPAAKIQEILALKQRWGLPDARLSAEPKAQPCAPAAPAKAHAAAARNGHHAAARNGHAAGQSARYRPEVEALIAEFTERILRLAEE
>NC_012483.1|WP_015895937.1|877425_878598_+|hypothetical-protein
MSAEIAGEKELNFGQTVDAVQAVTPLLVLQNENDQALVAVCPTLQGRVLTSTARGTQGRSYGWVNHDLIASKKHLEHFNPYGGEDRIWLGPEGGQYAIYFAPGTSFDLDNWYVPAPLDIEPFEVAEQSASHVRLTKKFRQVNYSGAEFEIGLNRVVRVLPAHQASSTLPAELLQGVSTVAFESHNVLTNLGTQPWTREGGLLSLWIIGQFNASPSATIVIPFHAGPEDKLGTPINTNYFAPLDEQRLRVFDGYACFKGDSGYRSKIGVNPHRVTGRLGSYDAEHNVLTMVEHSVNAPDAGYVNSEWQLQEHPYAGDVANCYNDGPRPDGTQLGAFYELESSSPAAALAPGATIEHTHRTLHFEGDKARLDAIARAAFGASLDEIASALPA
>NC_012483.1|WP_015895936.1|876287_877274_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MSGILVVLEHRNGAWARMSWEAMAAGQQLAAITGGNVYTAALGSDLSALTPEAASHGGAKLHTLESPQLAHYTADGYVLALEQLIRQHQPDFVVFPHTYQVRDFAPRLATRFGQVLIPDVIALRGDGGTPVFVRQLMQGKLNADYRKTGGGPGFVSVQAGAFRAEESAAPAPAAMEPFALTLDAAQIRTQPGEPFRESTQTVDLGSAPVIVSVGRGIKEQDNIPLVQALADALGAELAASRPICDNGWLPMERQVGSSGQTVAPKLYLAVGISGAIQHLVGMKGSKAIIAINKDENAPIFEVADYGIVGDLFEVVPALTEAVKKAKSA
>NC_012483.1|WP_015895947.1|895883_896177_-|CRISPR-associated-endonuclease-Cas2
MFLAIVSYDVCTRTPEGRRRLRQVARACEDYGQRVQNSVFECWVSSENFLMLRKRLVDIMDAGEDSVRIYFLGERWKGRVEHLGVKSVLDPQGPLIL
>NC_012483.1|WP_015895948.1|896210_897242_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MRPLLNTLFVTTQGSYLSRDGLTVSISVEREVRARVPIHTLNSIVCFGVVTCSPFVLQLASENGVSLVHLTEHGRFIARMQGRTQGNVLLRRTQFRTADDMSASARIARSILIGKVSNARTVLQRGARESESEVARERLEHAALRLARLMPDLARADDLDTLRGFEGDAAAIYFGAFDALIADPSDAFRFTGRSRRPPLDNVNALLSFLYALLASDVAAALETVGLDPQVGFLHRDRPGRASLALDLMEELRAPVADRVALSLINRRQVRSSGFERGDTGGITMADATRKAVLAEWQSRKTEEIRHPFLNEVVPIGLLPYVQSLLLARYLRGDLDGYPPMLWK
>NC_012483.1|WP_052294668.1|897238_897874_-|CRISPR-associated-protein-Cas4
MAFCERRWALVHVEQQWAENRYTVEGEQGHERAHSGIPESRPDLLIRRTLPLRSLRLGLSGQSDVVEFHPSTQPNAISLDGHAGRWQPVPVEFKRSRDKAGSIAYRLQLCAQAMCLEEMLSTSVIEGAIFDVSTRRREAVIFPAAVRREVERLAARMHSMRRGGKTPSAVPKPACRKCSLMDTCLPGLKMGNPQTEPVARYLQRAIKEHTI
>NC_012483.1|WP_015895950.1|897946_898858_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSTLQNRYDFVYYFDCLDGNPNGDPDADNQPRTDPETNEGLVSDVCLKRKVRDYVFHSKQKDGAQEHGFDIFVLSGNTLESRQRMPYDHLKLDSKDKSSSNIGQARAWMCQNFFDIRAFGAVMSTTDFNCGQVRGPVQFTFARSVDPVFTTEHTISRQAFTGEKDIKNSNGTFGKKHTLAYGLYRMHGFINPVFADIGPDPAKAKGTGFTEDDLALLWKALGGMFDLDHSAARGLMSPRELIVFKHASRLGEAPAQHLFERVSTRKKDGVTVPRSFEDYDLTTPPAGALAGHNVEVLYPLRRV
>NC_012483.1|WP_015895951.1|898854_900711_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MFVQALAGYADTHLRKQLDDVAFEERPVQYFLQIGKDGSFLGVIPRFTEVPVASPKQKKGSADKPPKTRLQPELLSVPRSPANRNSGLHPLLGSDDIKYVLGPGPWTKASELENHRDRHEAFVELLRRVAKETRDRALEICAQFYDQPEQVERAREALAKVTPGSNVALFVFGQPVTERDEVRAWWRQHYEASTAERGAGQTAECLISGVVGPIPSTHAKIKGTSALGGQPAGVSLMSFDKPAFRSYGWEQNANSPVSSDRAMAYVLALNDLLKPGSQNRKDFDGVAFLFWLKRDVDIDYNSLLEEPPSDVLLDKARAIIGLKNGAWMRQEERNELYMAAVSATGSRLVLRSWSSMPLEDALESLLGFWEQLKMQPLEKDKPPRAEPFWKLLHALDREGRPPASRTVALRRRALEGRCSPLGYRIVSDVLARMRADKEKRRDIAALGLLRLCLNDLHATTGKGEPMPAALDETEPPQHPAYVCGRLLALHDSLQWRTFDAAEEAQPNATVADRYYTLMMNSPAIGVAKVFDLGRKHLSKLRKLDAKSGTSYCDYFTRRICELEEHLGGEPPVQFDLHDKARFALGFYHEKAPRFRARKAESISTKLQANSNSTDEENQ
>NC_012483.1|WP_015895952.1|900692_901418_-|type-I-C-CRISPR-associated-protein-Cas5
MSLAVRLHVSGDFACFTSPASKVERYSYPLPTPSAARNILDAILWKPEFRWIVTRIMLVRHPRGTAGLPATIPLKRNEVQSTIAPGTVRQWMREPAAYQPLAAGAGQGTDGTPRMTTGLKNVAYVIEAYPHVFDSNGGENTPKKYVEMFERRAAKGQCFSRPYLGCREFAADFRLANETDVPLPVTENLGRMLYDIAQTPHGRRPHFFEAKLVDGEMLTDPKTVLLDESVRSEVLACSYKR
>NC_012483.1|WP_015895953.1|901448_901649_-|hypothetical-protein
MTRRDERHCTAAIPISKDQVLMITVDTVSIEVEMEAPPSSPPNGKAPVDGSDPADRPEIGFRLRKN
>NC_012483.1|WP_015895954.1|901814_904130_-|CRISPR-associated-helicase/endonuclease-Cas3
MTYWAHSDANRSPDEEGHRWQPLSEHLAQVAALARELAERATAPASALSTLAYAAGMLHDYGKYQECFQRMLHGGSSRCPHAIYGAIALRCFDEDGCGTDRKWAMPAVCAIAAHHAGLKDFSEHECITDPGNPAFAAEREIAQKLLGAAATDFPEIRSAFSREKSRLEQRSVDMQTRMLLSCLVDADRLNTAGRLLVQQELHSEHRLEQMNIYLDRVADAARKRGTAASVLNVRAQVQQHCSDAAKQSPGVFSLCVPTGGGKTLGAMRFALEHAAHSQGKLRRVIVVIPYLSIIEQNAKIYADVFGPEAVLEHHSGAVTPLMRSERETTSTTCASEEDEISPSVHPRTIETENWDAPVIVTTSVRFFESLFSNRPSDLRRIHNIARSVIILDEVQTIPRRLLAPLLGMLRELAEEWGCSVVLSTATQPAFEARNPRQTYLFPFGSIKPIIPGETSAAMARTLQRVQIDWEIEDRIRWEELATRLAEQRQVLCVVNLRDHAATVFDGLRTRLPSEEQTGLFHLSTRMCAQHRLRVLDEIRHRLGAGLTCRIVSTQLIEAGVDLSVPIAFRALGPLDSIIQVAGRVDREGTASAAAGAPAGKLIVFRPEDERYPGMDYKAAAAITQGVLDEFESLQTDHLRSISDYFQRYYESGGTGGRGEHLADMRQRDNPYFAELADAFEMIESRTATVFVPYGEGASLLRELADTRQLDRDLLRKLQRYTVSLQRYEFEAAKSQGLFEIWSGSDLWTCDAAQYSAEKGLLPQLPAQAFVV
>NC_012483.1|WP_015895956.1|907256_908711_+|D-xylose-transporter-XylE
MARLNKYVVFLALIATFGGLLFGYDTAVINGAVDSLKAYFINPRFSDLANPAQADAASSLLGFVVSSALIGCIIGGLMGGWVSTVIGRKRGLVIAAVLFLISALGASAPEFPFAPIGHGGPAYMWNFVIYRILGGIGVGLASMLSPMYIAEIAPPKVRGNLVAWNQFAIIFGMLVIYFVNYGISKGGNGDAWLNSIGWRYMFLSGAIPASIFLLLLLFVPETPRYLMMKGQEAKARTVLDKLVTKEEADRELREIRASLSQNHSGKLFSFGAFLIFSGMLLSIFQQFVGINVVLYYATDIFKGMGMSTNAALMQTIIVGAVNLTFTVIAILTVDRFGRRPLQVVGGLIMAASMTWLGIELWTGGKGLGALIAMLVYTAGFAVSWGPVTWVLLSEIFPNQIRGKAMAIAVAVQWVANYLVSWTFPILNNNPFLVKHFHHGFAYWIYGVMSILAALFVWRKVPETKGRTLEQMESLWGSLKKAAIG
>NC_012483.1|WP_015895957.1|908796_909858_-|LacI-family-DNA-binding-transcriptional-regulator
MSKDKPQRKTTISDVAREAGVAQMTVSRVVNGGNYVSAEVRERVQRAIAKLGYQPNEAARILKGQRARTIGLIVPTLADSFFSACAHTVQEVATRHGYMTLIQTSSNRAEVETGEIDMMVARNVAGLILVPMEMKASPGLLAVQSAGIPIVTLDRVVKGLSASEVLVENAIGAEEGVRHLIGHGHKQIACLGYDADLLSIQERIHGYTTAMKEAGLHPQIWKVESARSVALTLQRKLEGPQPPTALFTLNNVTTIQTLHTLQQLGIKLPRDLALVGFDDLELASLLTVPITVVRQSAHELGRSGAKLLFDMIRTGAPMKELPKTRLVLPTELVIRNSCGCKGVSREIVAAGRG

Crispr_ID: NC_012483_2

• CRISPR_ID: NC_012483_2
• CRISPR_location: 1055508-1055695
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_012483_2

Consensus_repeat	Method
AATGTGAATGGGGATTCGCATTTTC	CRISPRCasFinder

spacers of NC_012483_2

>2.1|1055533|56|NC_012483|CRISPRCasFinder
AGGCAGAAAATGGCGTAGTTTTCAGGTAAACCTCACATTCCAATAGGCTTGCCGTC
>2.2|1055614|57|NC_012483|CRISPRCasFinder
TGTGAAAAACAGGCCGGATTGCCGGTTTAAGTCTTTTGTCTATAATCATTTGCGCGG

CRISPR arrays and Neighbor proteins around NC_012483_2

CRISPR arrays

The CRISPR arrays of NC_012483_2

>merge|NC_012483|2|1055508-1055695|CRISPRCasFinder
AATGTGAATGGGGATTCGCATTTTCAGGCAGAAAATGGCGTAGTTTTCAGGTAAACCTCACATTCCAATAGGCTTGCCGTCAATGTGAATGCGGATTCGCATTTTCTGTGAAAAACAGGCCGGATTGCCGGTTTAAGTCTTTTGTCTATAATCATTTGCGCGGAATGTGAATCTGGATTCACATTCCG

>NC_012483|2|2|1055508-1055695|CRISPRCasFinder
AATGTGAATGGGGATTCGCATTTTC	AGGCAGAAAATGGCGTAGTTTTCAGGTAAACCTCACATTCCAATAGGCTTGCCGTC
AATGTGAATGCGGATTCGCATTTTC	TGTGAAAAACAGGCCGGATTGCCGGTTTAAGTCTTTTGTCTATAATCATTTGCGCGG
AATGTGAATCTGGATTCACATTCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_012483.1|WP_041839275.1|1050176_1050617_-|6-carboxytetrahydropterin-synthase	unknown	unknown	gnl|CDD|238264
NC_012483.1|WP_015896072.1|1058026_1059283_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|223650
NC_012483.1|WP_015896069.1|1054156_1054675_+|septal-ring-lytic-transglycosylase-RlpA-family-protein	unknown	unknown	gnl|CDD|223868
NC_012483.1|WP_148215026.1|1061203_1063282_-|beta-galactosidase	unknown	unknown	gnl|CDD|367090
NC_012483.1|WP_041839280.1|1071332_1071863_+|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_041839278.1|1056502_1057741_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|182528
NC_012483.1|WP_015896062.1|1047882_1048518_+|arylesterase	unknown	unknown	gnl|CDD|238860
NC_012483.1|WP_015896078.1|1070038_1071172_-|aminofutalosine-synthase-MqnE	unknown	unknown	gnl|CDD|213851
NC_012483.1|WP_015896076.1|1068011_1069478_+|hypothetical-protein	unknown	unknown	gnl|CDD|371693
NC_012483.1|WP_148215237.1|1052257_1052704_+|redoxin-family-protein	unknown	unknown	gnl|CDD|239264
NC_012483.1|WP_083770507.1|1059396_1061106_-|beta-xylosidase	unknown	unknown	gnl|CDD|366525
NC_012483.1|WP_041839276.1|1050613_1051024_-|6-carboxytetrahydropterin-synthase	unknown	unknown	gnl|CDD|376501
NC_012483.1|WP_148215025.1|1049532_1050165_-|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl|CDD|236472
NC_012483.1|WP_041839914.1|1051074_1052124_-|glycosyltransferase	unknown	unknown	gnl|CDD|213815
NC_012483.1|WP_015896067.1|1052710_1052983_-|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_015896080.1|1072054_1072513_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|223532
NC_012483.1|WP_041839274.1|1048548_1049424_-|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl|CDD|211339
NC_012483.1|WP_015896068.1|1053016_1053928_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl|CDD|223428
NC_012483.1|WP_148215027.1|1063694_1067540_-|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl|CDD|379297
NC_012483.1|WP_015896077.1|1069623_1069803_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_012483.1|WP_041839275.1|1050176_1050617_-|6-carboxytetrahydropterin-synthase	gnl|CDD|238264	cd00470, PTPS, 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is PTPS which catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin. The functional enzyme is a hexamer of identical subunits.	1.37685e-40
NC_012483.1|WP_015896072.1|1058026_1059283_-|ABC-transporter-permease	gnl|CDD|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	3.53908e-47
NC_012483.1|WP_015896069.1|1054156_1054675_+|septal-ring-lytic-transglycosylase-RlpA-family-protein	gnl|CDD|223868	COG0797, RlpA, Lipoproteins [Cell envelope biogenesis, outer membrane].	3.01008e-47
NC_012483.1|WP_148215026.1|1061203_1063282_-|beta-galactosidase	gnl|CDD|367090	pfam02449, Glyco_hydro_42, Beta-galactosidase. This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.	2.28871e-54
NC_012483.1|WP_041839278.1|1056502_1057741_-|ABC-transporter-permease	gnl|CDD|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	3.60572e-41
NC_012483.1|WP_015896062.1|1047882_1048518_+|arylesterase	gnl|CDD|238860	cd01822, Lysophospholipase_L1_like, Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity.	8.02695e-75
NC_012483.1|WP_015896076.1|1068011_1069478_+|hypothetical-protein	gnl|CDD|371693	pfam11721, Malectin, Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognizes and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan.	6.16158e-27
NC_012483.1|WP_148215237.1|1052257_1052704_+|redoxin-family-protein	gnl|CDD|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	4.03876e-34
NC_012483.1|WP_083770507.1|1059396_1061106_-|beta-xylosidase	gnl|CDD|366525	pfam01229, Glyco_hydro_39, Glycosyl hydrolases family 39.	4.60219e-89
NC_012483.1|WP_041839276.1|1050613_1051024_-|6-carboxytetrahydropterin-synthase	gnl|CDD|376501	pfam01242, PTPS, 6-pyruvoyl tetrahydropterin synthase. 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.	4.03314e-42
NC_012483.1|WP_148215025.1|1049532_1050165_-|GTP-cyclohydrolase-I-FolE	gnl|CDD|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	3.35789e-107
NC_012483.1|WP_041839914.1|1051074_1052124_-|glycosyltransferase	gnl|CDD|213815	TIGR03469, HpnB, hopene-associated glycosyltransferase HpnB. This family of genes include a glycosyl transferase, group 2 domain (pfam00535) which are responsible, generally for the transfer of nucleotide-diphosphate sugars to substrates such as polysaccharides and lipids. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. Indeed, the members of this family appear to never be found in a genome lacking squalene-hopene cyclase (SHC), although not all genomes encoding SHC have this glycosyl transferase. In the organism Zymomonas mobilis the linkage of this gene to hopanoid biosynthesis has been noted and the gene named HpnB. Hopanoids are known to feature polar glycosyl head groups in many organisms.	1.8774e-47
NC_012483.1|WP_015896078.1|1070038_1071172_-|aminofutalosine-synthase-MqnE	gnl|CDD|213851	TIGR03700, mena_SCO4494, putative menaquinone biosynthesis radical SAM enzyme, SCO4494 family. Members of this protein family appear to be involved in menaquinone biosynthesis by an alternate pathway via futalosine, based on close phylogenetic correlation with known markers of the futalosine pathway, gene clustering in many organisms, and paralogy with the SCO4550 protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	0
NC_012483.1|WP_015896080.1|1072054_1072513_-|GNAT-family-N-acetyltransferase	gnl|CDD|223532	COG0456, RimI, Acetyltransferases [General function prediction only].	2.16638e-20
NC_012483.1|WP_041839274.1|1048548_1049424_-|tRNA-pseudouridine(55)-synthase-TruB	gnl|CDD|211339	cd02573, PseudoU_synth_EcTruB, Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). E. coli TruB and M. tuberculosis TruB make psi55 in the T loop of tRNAs. Psi55 is nearly universally conserved. E. coli TruB is not inhibited by RNA containing 5-fluorouridine.	7.5503e-97
NC_012483.1|WP_015896068.1|1053016_1053928_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl|CDD|223428	COG0351, ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme metabolism].	7.32932e-89
NC_012483.1|WP_148215027.1|1063694_1067540_-|carboxypeptidase-regulatory-like-domain-containing-protein	gnl|CDD|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	3.00622e-22

Protein sequences

>NC_012483.1|WP_015896069.1|1054156_1054675_+|septal-ring-lytic-transglycosylase-RlpA-family-protein
MNPIERNRDSANRRHLHPVGVAVMILVGLAGAQASTPTIRPALQAEHAAPAVKRVRRHHHWYQIGIASWYGKFFQGKETASGEPYNMNAMTCAHRTLPLGSLVRVTNLRNDKSVVVRVNDRGPLPENRVIDLSYAAAGFLGLRHSGTAPVRIELIKTNAQLAQLSYPLTPAR
>NC_012483.1|WP_015896068.1|1053016_1053928_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MPSKPSGFLSGNPGNPHEQRLPETEPAQSSALAPAVVLTIAGFDPSSGAGITADLKVFAACQLYGVSAVTALTVQSTQGVLRSQPVDSALLGETLRCLQQDLPIAGVKIGMLGSGENVATVAAWLRDFSFPRERVVLDPVLRSSSGRDLLDASGQTLLREQLLPQTGWITPNLDELAALTGLPVTNREQMRAAAEALAATAGLRVAATGGHLDPPDDLLATPEGEAQWFPGRHLATRATHGTGCAFSSALLCRLVLGDSAEAAVAAAKQYVKEAMEAAYPIGRGRGPMHHLYRAFRGECLSNG
>NC_012483.1|WP_015896067.1|1052710_1052983_-|hypothetical-protein
MTQLEVLYRYEMHPTEAAMAALGTARQVYGVRRIKIDENAKTIRVEYDATRLNKAVVLQLLRRSGIDIVEEIPLVAPPPPPAPAEAAPAQ
>NC_012483.1|WP_148215237.1|1052257_1052704_+|redoxin-family-protein
MAGGCNDNTHPGAIGHPAPNFTIHNGAETVSLKQYRGHVVVLNFWASWCPPCLEEFPSLIKLQQEMPDIRVVAVSFDTDKQAYDQYLLQNRIGGITTAIDPTQKTNRKFGTTRPPETYIINRKGVIVRKFIGPQDWTSPEIVNYLKAL
>NC_012483.1|WP_041839914.1|1051074_1052124_-|glycosyltransferase
MDSAPSPSRVLSVIVPARNEEDCIEACLRSLAVQSEPGWDLGREWEILLVNDASTDRTRALAAAIPGVTVLDAPPPEPGWTGKANACMAGVRAARGQWLLFTDADTVHEPGHLSLAITEAERHHVEMLSYSPRQIVHGFWQRALMPLVFSELASAYPPAKVNDPAHRTAAANGQFLLVRREAYEKIGGHAAVMDFVLEDVALANLAKRRKVGLRFRYAPEAVAAHMYRDFQAMWQGWTKNLALLFGNALALAAWRLLDLVLLLGLPFGAWAVYRLNPHVWYWAVFLLLWLRTLLRFYRRVSRSNFAAKDCMLAPVGLPLFAAMLWQSWFDHTVKKRVVWKGRTLESANR
>NC_012483.1|WP_041839276.1|1050613_1051024_-|6-carboxytetrahydropterin-synthase
MILLTRKADFSAAHFYWNDAWTEDQNVAAFGKCANRNGHGHNYTLEVTVAGEVDAVTGFVVDLKQLKEVIEREVISVYDHRHFNHEVPEFRSVIPTTENIAIAIWKRLEGKIPGARLYKVRVYEMPDLFAEYRGEA
>NC_012483.1|WP_041839275.1|1050176_1050617_-|6-carboxytetrahydropterin-synthase
MKAYFGRRYGFSASHRLHTDELSEAENRATYGKCNHPFGHGHNYVVEITVGGPVDPDTGMVCNLVDLDACVREQVLEPFDHTNLNLLSCFEKLVPTTENLCIEIDRRIRQAFREAEIFSVRVEETNNNFFEIEHSAPGTGSTAGRK
>NC_012483.1|WP_148215025.1|1049532_1050165_-|GTP-cyclohydrolase-I-FolE
MATISLQDKLSRNSGSVPPALEKYSTQEIYAELLRRYDEDPTRDGLLRTPERVEKAMKYLTQGYHQEPAGILQGALFDVDYDEMVLVKDIEMFSLCEHHMLPFFGRVHVAYIPNGKVVGLSKIPRLVEVFARRLQVQERMTRQIAEAIQDAINPQGVGVVIEARHLCMMMRGVEKQNSSTVTSAMLGVFQQQNTRGEFLSLVRDRSYQQL
>NC_012483.1|WP_041839274.1|1048548_1049424_-|tRNA-pseudouridine(55)-synthase-TruB
MNGLLIVDKPGGITSHDVVARVRRATGEKSIGHLGTLDPMATGVLPLLLGKFTRLAQYFGSSEKSYTGTIRFGFATDTYDAEGQPSSEPRPLTHSLEELRALAARFQGQIEQMPPPFSAKKIGGQPAYKAARAGETPQLRAVPVTIHEFVLESLAEDTAAFRMQVSAGGYVRSVAHELGAAAGCGAHLASLRRTAAGAFTLAEALPLDEIECLAAAKELEARMPHPRAILPEMPAVTTDLQTAGRLRNGMQVNLPDFSTAPMVRIFVGQRDLIAIGRRVAGTLFQPVAVLG
>NC_012483.1|WP_015896062.1|1047882_1048518_+|arylesterase
MNRRRLRFWLLLVCFAISLSSIARAAAHEPLVVCFGDSITAGHGLDPSQAYPVFLQHDLASRGYHYRVINAGVSGNTTKDALDRLPRVLGLHPAAVIVEFGGNDGLRGFPLNVTERNLGTLVGRLRAAHIPVLLAGITLPPNYGQDYIHQFDEMYRRVAQKYHVPLLPMLYAGIYNLPGTIQPDGIHPTAKGSRLIAQHLLPLLLPLLHRK
>NC_012483.1|WP_041839278.1|1056502_1057741_-|ABC-transporter-permease
MLRDIWNQAWEAMVYNRRRTMITICGMAWGIATVVLLLAYGAGFSKAIHNIFAQWGLQMMGVFPGQTSEQAGGMKAGIPVHFVMDDLDHIRNTVPGIELMSPELGKTFPVSNDLHSYQWQVNGDYPDIASIQNLEISVGRFYNGQDNLERSHVAVLASEAKTMLMGGQYPLGQQIRINGTPFTVIGVLKPKMAEAGDNVNRQVYIPFGAMAELKDSQYLDGIWMTYRGDNQAVEQALRNTLAAAHNFEPSDHNAMYVANLQQQLQQFSIITAALQILLLFIGALTLGIAGIGLMNIMLVAVQQRTREIGIEKALGARRRHILLQFLAEAMVITGVGGAGGIALAYAVALGVGRITFYSAIAKNAHAADIRLLISPLIVLVATIILILVGTVSGMIPAIKAANLNPIEALRYE
>NC_012483.1|WP_015896072.1|1058026_1059283_-|ABC-transporter-permease
MQSFGDIFGQVFRAIWANKLRSFLTMFGIAWGVGSMLLLIGVGEGFRVGQRQQLSRFGSDVIMMWGGNVPAVPSQHVGMRPYYLTLRDEQAIVTQAPDVRDATAFLERGNLQEQSLYETITGTVDGVQINYPKVRNLPIAEGRFLSPSDELNRNNVAVLGQKSAIKLFPGHPALGSWVTLGGTRFLVIGVAQKIGHGDNNNLNQQVYIPLSVMRNKFPLKGDNIPTDAVTTIQYQPRSHAVHLAALAEVHTIIARRHGFDPNAPQAFNEWDTIQTVQMVDKIFDAMDTFLGGVGLVTLALGAVGIVNIMLVSVTERTREIGLRKAIGATSRSILMQFFLEGITLTGVSGLIGIGGATGFMWLLQKAIGQGVQGFAPPHVVPWTAALAFGSLTVCGVLSGIYPASRAAALEPVEALRKE
>NC_012483.1|WP_083770507.1|1059396_1061106_-|beta-xylosidase
MRPILKLPTRPIPRPTRSRKRSILKHASLKALVRHPRLSFLKAASVAVAVTFAAHAVAQSPSHQPRVITANVQAAAGPVNRFFDFSVGSDYSGTLIKADSQNQLQMVTDELGFRYIRFHAIFHDALGTVQQKNGKIVYNWTGIDELYDNLLARHIKPFVELSFTPQALATSKNSIFYYHANTSHPNPKEWRNLIAAFARHLEKRYGKAEVRSWYFEVWNEPNLSGFWEGGDQKAYFQLYDLTARTLKSVDRQLRVGGPATAGAAWIPAFLDYVKKTHAPIDFVTTHTYGVKGGFLDPDGKDDLLLDPSPNAIVGDVRRVHQQIAASPFPHLPLYITEWSTSYTPADPVHDSYISAAYILNKLKATQGLAQGMSYWTYSDLFEESGPPPAAFYGGFGLVTRDGIRKPAFFAYKYLHALRGETIPSSDPQSMLSTNGQNFTAVLWDFQTPAQGKLGDREFYTRLLPDHAAAPVDLTVTHLTPGTLYRLQLHRTGYGVNDAYSEYLRMGAPKNLTQPQIAHLDYLTRDQPERNQLLRAGSDGTIALHIPMRTNGIVLVTLRRVYSASPNPRH
>NC_012483.1|WP_148215026.1|1061203_1063282_-|beta-galactosidase
MPKAVALALSFALALPTVASAQSAAGHPDWPGPGQLYVGTCYQPIERTPREIDQDIALMKKSGFKVVRLGDLSWDSFEPEQGKFTFAWWDSIIQKMQAAGIKVILDIPGTPAPIWLHRAYPGVDIVAEDGKRMPPAERYMDDISDPDYIREVGILATAMMKHYAHNPDIIAIGYDNEIGNGYMSYSEADRLRFIAWLRKKYGTIGALNHAWATEWWSRRLNNFNQVYMPLASGPGPSESYLDLHRFWSDVAIARLEQLEALRRQYMPNVPTISNLWPNAGRRGFNYLGSYKNYVSYGAEGFYPGDPVSGAFGALMMKGDLPTPIWFNEFTAGGGGFYGTPGRSTMYAYLGLMIGAQGFLAWTFNSHLGGEEQALFGLLDHDNTPSWKLNEWAHFAAQFQTLSHYGFPRYPHPQIAIAYSFDSFVDSHPNGPSNTTLQYFTTPYADQVQAAFAPLFRDNLDTAIINIGHADLSPYKMVVVPADYLMDPASAHAIRTYVRNGGTVLMTAFSAKVDENGNWFDTPLPGMLSDVFGLRTSAFYRVQKPLTFDLNGHSVATTLREYEVLEPSTAKVIARFTSTADRTPAVTVNHFGKGRAIYLATASNATSIGPVMQSLFASCGIQPGPRTPEGVYARRVDGRILYVNTTQQNQVIPIHGTGQGIISHHTYHGQILLKPWQSDLVQATGAHAAPANQ
>NC_012483.1|WP_148215027.1|1063694_1067540_-|carboxypeptidase-regulatory-like-domain-containing-protein
MQKCFSQFRTAMHKFERGLSMSQSGRGRSLSAKISRPAVFLTLVFALLCVPALRAQTTASLTGAVTDPTGAVVPGAKVTLTNDATGAERDTVTDSAGDYNLQALLPGTYTIHVSENGFQAYEQHGLTLTAGADAKLPDIKLALGSATQTVTVHTNTQILPTVSGEHSVVLSSQDIHKLALGSRDLSEMLKILPGVTVSPSLSNGPSFNFTQVSAAQSAINNGLSANGAPYRGGTTQLLDGVDVNDPGCNCNAITLINPDMTQEVSVETSNFGAQSPYGPVLVSTISKSGGSHYHGEGYFYARNDVLNANDWQSNHQGLPRGNAHYYYPGGNIGGPVPGTHKKLRFWGGYERFLQNTGNTNYLRSFIPTPDMMAGNFGDTPANAAFCQGASNINSSQTNGCNDLTGTILPNGQAAGPGTSYGSTIPAQFLDAGAKALSSFWPTANANPATTPGGYNYYQVIPGTNNGWMYRLRVDYDPNPSTQFYVSYQQSYSAALASGNGAHIYWTPYASIPYPGGGLYGYSYTKAISAHLVHTFGPNLTNELIAAWGYGNFPTEPSNPNAATRSGLGYPYGTIFSTGSNVLPSYSSAGYDTFPDFSQPDYFENSSHSFENKKETPSLADNVVWQVKNHTIKLGGFAEEVSNDQGGTETLNGNFGSFSFNGTVAPNVVTGQAVGSPNNPTANFLMGIASSYNENNTSQNLNMAFGDFAAYYDDTWQATKRLSIEYGMRIEHIGHWYDKNKNGVAVFMPSLVVPDYNEGRLYPGVRWHGVDPGVPSSGMPNRFAYMTPRIGASYDIFGNGKTLIRGGWGIFRFTNQPDTNSVLTAQEVLGYNLPSGDSIFLSQVGQAGQQGGIAGQGSAPGISIPTADCSAATGCINNTVYAENPLDDQIPDSTAWNVTLDQQLPMQMMVEAAYVANHAENLPLGSEELSGSGFSAFDDVNKIPLGAFFKPDPVTGMVAKNPEQVNATCTGNTCNQYADYHPYGKEYGNNSVYVTDTAGYSNYNSLQLSLVRHGSNANFDVNYTYQSNLSTTLGEDAFSVRRNYGYASTTRRHVFNFSGSYTFQRPYKGENHWLRGAANGWTISNITTWQAGGFLQTQATPNFGLTLQYGDYNGAPISKKNPLPNGATGNSLSQATYYGTNSTVDIMPEVTCNPASGTANNQRIKYSCFTPPKVGQYGPRDYPYTMAAYFDSDMSLYKNFHVVRSQTLEFRIQAFNWLNHPLPEYSASSQLALHYTDAYGTSNFGTSASQYPNGNPNNFGVMDTKSGQPNQRTLELSVKYMF
>NC_012483.1|WP_015896076.1|1068011_1069478_+|hypothetical-protein
MLSLITYIGEKYFADETEKLREYEIATEVFDRSKNTFNSGEDAIVRVEAHRLRKRLKKYYDTDGQDHAVQFTIPAGSYVPVFSHRVQPQEDGLEDGVEQPEDAESPVEERIEPTPRKKRGRVYVIAAILLVALLVGAGALVIYRQHRRRISASPPTAGNAPIRHASASGPFPQMPLRILAGYKGKPQIDNAGAVWQPDEYYHGGGSWDRPESYGPVRKTSDPLLFQHWREGNFSYDIPLPQGVYDVHLFFVSAQPYANTPSTFNVLVNGKAILPYFDVNMDAMGPDVADERVFRDVSPGPDGVLHLSFTSYTVPASVNAIEIVPGEAHHELPIRIVAQSRAYTDHSGALWEPDDYYSGGYTSETNFAVTETADPELYAAERYGYFSYSIPVDARDQYTLILHFAELYFGPNRPGGGGAGSRVFRIECNGQTLDKGLDIYKSAGSMHALTETFHHLVPTPQGKLNVTFDPIENNATVSAIEVVDEGPQS
>NC_012483.1|WP_015896077.1|1069623_1069803_-|hypothetical-protein
MPLSGEAIRMMNYVDDVAVTLRRILALVPSLTPEERERVSEYVRNSRPNAESVLEALKK
>NC_012483.1|WP_015896078.1|1070038_1071172_-|aminofutalosine-synthase-MqnE
MPSQQHAFVSDDPRLQPIAEKVLASERLSFEEGVTLYRSPDILAVGWLANHVRENLHGDVAYFNVNRHINPTNVCVAACRLCAFGRKKGTEGSYTMALEQAWETAASGYTEAVTEFHIVGGLHPDLPLEYFEDLVRGLKERFPQVHIKAFTMVEIAFLARRAKLTIPETLRRLKDCGVDSMPGGGAEIFSDRVRHIICDHKIDGSEWLDTARMVHQAGLKSNATMLYGHIESDEDRVDHLIKLREVQDETHGFQTFIPLAFHPDNTPLEHLPRTTGLTDIRQIAVSRLMLDNFPHIKAYWQMMTAKIAQIALRFGADDIDGTVIEEKIYHDAGATTPQGMRREELMRLITAAGRVPVERDTLYRAVTRSEDTFTVAV
>NC_012483.1|WP_041839280.1|1071332_1071863_+|hypothetical-protein
MVRLALFGVLGPLALLAAAGAQTPVRFPAVTAYSLAKSKVALPADLKGKLNLLVLSFDVSQSPEVDRWLREAQSLERLHEGLRYYVLPVSERENDLYRWWQNSSMRGNYSDPQEWPRIVPLYVNRKQFRGALQIPKDRSVVVLLTDAQGEVLWRTHGKLDQEKQAEIERQLLAVSY
>NC_012483.1|WP_015896080.1|1072054_1072513_-|GNAT-family-N-acetyltransferase
MWTLREATSADYNGFYHLDQQCFPPGIAYSRADFRAFLSQPHSIALLAEGATGALLGFILAGQRRRGELHYGYVVTIDVAESARRQGVGRALLFAVEKHLREEGLASIRLEVAVDNLAAQQFYEREQYRPIGRIPRYYMDKIDALVLEKSLL

Crispr_ID: NC_012483_3

• CRISPR_ID: NC_012483_3
• CRISPR_location: 2539434-2539633
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NC_012483_3

Consensus_repeat	Method
ATGTTCCACGTGGAACAT	PILER-CR

spacers of NC_012483_3

>3.1|2539452|37|NC_012483|PILER-CR
GAAAGCTAGAGACTCGCTGCGGAGGACCTGCAGAGTG
>3.2|2539507|40|NC_012483|PILER-CR
CGGAGTTCAGCCTGGGGCTGCTCTTGAGCGCAGTATGCGT
>3.3|2539565|51|NC_012483|PILER-CR
AGAAGGTCTTCAAGATGCTGGACCGGGTGGTCCCGGGTGAAAACGGGACGG

CRISPR arrays and Neighbor proteins around NC_012483_3

CRISPR arrays

The CRISPR arrays of NC_012483_3

>merge|NC_012483|3|2539434-2539633|PILER-CR
ATGTTCCACGTGGAACACGAAAGCTAGAGACTCGCTGCGGAGGACCTGCAGAGTGATGTTCCACGTAGAACATCGGAGTTCAGCCTGGGGCTGCTCTTGAGCGCAGTATGCGTATGTTCCACGTGGAACATAGAAGGTCTTCAAGATGCTGGACCGGGTGGTCCCGGGTGAAAACGGGACGGGTGTTCCACGTGGAACAT

>NC_012483|3|2|2539434-2539633|PILER-CR
ATGTTCCACGTGGAACAC	GAAAGCTAGAGACTCGCTGCGGAGGACCTGCAGAGTG
ATGTTCCACGTAGAACAT	CGGAGTTCAGCCTGGGGCTGCTCTTGAGCGCAGTATGCGT
ATGTTCCACGTGGAACAT	AGAAGGTCTTCAAGATGCTGGACCGGGTGGTCCCGGGTGAAAACGGGACGG
GTGTTCCACGTGGAACAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_012483.1|WP_052294782.1|2547289_2548786_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl|CDD|235392
NC_012483.1|WP_015897270.1|2538054_2538804_+|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl|CDD|224982
NC_012483.1|WP_041840187.1|2546253_2547240_+|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl|CDD|223730
NC_012483.1|WP_148215273.1|2544585_2545650_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|223506
NC_012483.1|WP_041840183.1|2527068_2527566_-|tryptophan-rich-sensory-protein	unknown	unknown	gnl|CDD|320706
NC_012483.1|WP_015897268.1|2535864_2537199_+|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	unknown	unknown	gnl|CDD|223362
NC_012483.1|WP_041840184.1|2530885_2531872_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|379293
NC_012483.1|WP_015897277.1|2543781_2544504_+|DUF72-domain-containing-protein	unknown	unknown	gnl|CDD|376655
NC_012483.1|WP_015897273.1|2540781_2541714_+|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl|CDD|275105
NC_012483.1|WP_083770580.1|2537195_2538014_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|153251
NC_012483.1|WP_015897261.1|2527662_2529708_+|threonine--tRNA-ligase	unknown	unknown	gnl|CDD|234752
NC_012483.1|WP_015897262.1|2529704_2530889_+|putative-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|225420
NC_012483.1|WP_041839489.1|2532672_2533053_-|DUF2752-domain-containing-protein	unknown	unknown	gnl|CDD|378499
NC_012483.1|WP_015897274.1|2541783_2542941_-|glycosyltransferase	unknown	unknown	gnl|CDD|340848
NC_012483.1|WP_041839490.1|2545639_2546224_+|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_148215122.1|2548814_2549375_-|single-stranded-DNA-binding-protein	unknown	unknown	gnl|CDD|224760
NC_012483.1|WP_015897264.1|2532379_2532664_-|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_015897272.1|2539851_2540703_+|ParA-family-protein	unknown	unknown	gnl|CDD|379293
NC_012483.1|WP_015897267.1|2534846_2535515_-|cytochrome-c	unknown	unknown	gnl|CDD|379187
NC_012483.1|WP_015897276.1|2543021_2543528_-|DUF4112-domain-containing-protein	unknown	unknown	gnl|CDD|379180

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_012483.1|WP_052294782.1|2547289_2548786_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl|CDD|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NC_012483.1|WP_015897270.1|2538054_2538804_+|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl|CDD|224982	COG2071, COG2071, Predicted glutamine amidotransferases [General function prediction only].	3.96126e-56
NC_012483.1|WP_041840187.1|2546253_2547240_+|alpha/beta-hydrolase-fold-domain-containing-protein	gnl|CDD|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	2.17366e-26
NC_012483.1|WP_148215273.1|2544585_2545650_+|alpha/beta-fold-hydrolase	gnl|CDD|223506	COG0429, COG0429, Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only].	2.98433e-62
NC_012483.1|WP_041840183.1|2527068_2527566_-|tryptophan-rich-sensory-protein	gnl|CDD|320706	cd15904, TSPO_MBR, Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family. This family contains tryptophan-rich translocator protein (TSPO), an integral membrane protein that is highly conserved from bacteria to mammals. In eukaryotes, it is mainly found in the outer mitochondrial membranes of steroid-synthesizing cells of the nervous system where it transports cholesterol into mitochondria. It is known to be highly expressed in metastatic cancer, steriodogenic tissues, as well as inflammatory and neurological diseases such as Alzheimer's and Parkinson's. TSPO is also known as the peripheral benzodiazepine receptor (MBR) and its ligands include benzodiazepine drugs, implicated in regulating apoptosis. In human, a single polymorphism A147T is associated with psychiatric disorders; the mutation causes structural changes in a region implicated in cholesterol binding. TSPO is homologous to bacterial tryptophan-rich sensory proteins, and their tryptophan residues are believed to be functionally important. In bacteria, TSPO acts as a negative regulator of expression of specific photosynthesis genes in response to oxygen/light; it catalyzes a photooxidative degradation of Proto porphyrine (PpIX). R. sphaeroides TSPO (RsTSPO) is involved in porphyrin transport, similar to human, while Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.	8.79334e-47
NC_012483.1|WP_015897268.1|2535864_2537199_+|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	gnl|CDD|223362	COG0285, FolC, Folylpolyglutamate synthase [Coenzyme metabolism].	4.57263e-133
NC_012483.1|WP_041840184.1|2530885_2531872_+|AAA-family-ATPase	gnl|CDD|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	1.12969e-28
NC_012483.1|WP_015897277.1|2543781_2544504_+|DUF72-domain-containing-protein	gnl|CDD|376655	pfam01904, DUF72, Protein of unknown function DUF72. The function of this family is unknown.	8.17661e-63
NC_012483.1|WP_015897273.1|2540781_2541714_+|ParB/RepB/Spo0J-family-partition-protein	gnl|CDD|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	2.60291e-68
NC_012483.1|WP_083770580.1|2537195_2538014_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	1.07647e-53
NC_012483.1|WP_015897262.1|2529704_2530889_+|putative-DNA-binding-domain-containing-protein	gnl|CDD|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	1.23793e-59
NC_012483.1|WP_015897261.1|2527662_2529708_+|threonine--tRNA-ligase	gnl|CDD|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0
NC_012483.1|WP_041839489.1|2532672_2533053_-|DUF2752-domain-containing-protein	gnl|CDD|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	1.58709e-05
NC_012483.1|WP_015897274.1|2541783_2542941_-|glycosyltransferase	gnl|CDD|340848	cd03821, GT4_Bme6-like, Brucella melitensis Bme6 and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.	1.05528e-81
NC_012483.1|WP_148215122.1|2548814_2549375_-|single-stranded-DNA-binding-protein	gnl|CDD|224760	COG1847, Jag, Predicted RNA-binding protein [General function prediction only].	1.89365e-23
NC_012483.1|WP_015897272.1|2539851_2540703_+|ParA-family-protein	gnl|CDD|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	6.64241e-81
NC_012483.1|WP_015897267.1|2534846_2535515_-|cytochrome-c	gnl|CDD|379187	pfam13442, Cytochrome_CBB3, Cytochrome C oxidase, cbb3-type, subunit III.	2.01604e-08
NC_012483.1|WP_015897276.1|2543021_2543528_-|DUF4112-domain-containing-protein	gnl|CDD|379180	pfam13430, DUF4112, Domain of unknown function (DUF4112). This family has several highly conserved GD sequence-motifs of unknown function. The family is found in bacteria, archaea and fungi.	1.25126e-33

Protein sequences

>NC_012483.1|WP_015897270.1|2538054_2538804_+|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MTRPRIAIPEPTLNNAKYNERSWIQYANAVEAAGGEPVKIALSAAPAEIARTLASCQGVLLPGSPADVNPAKFGEAVAGAKPEDPAREAADELLLQDAFNLRKPVLGICYGFQSMNVWLGGSLVQDLPTQRPDSPVNHSPKEKPAVAHTVRLAEGSRLVGLAGQAESPVNSSHHQAVARLGDGLVLAGSCPEDGVIEAAEGRTGAYVMGLQWHPERTLETDAFSRRIFESFLEAVKAWKEVPNGAGSAQ
>NC_012483.1|WP_083770580.1|2537195_2538014_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MSTQTLAPRPEKLSLGERIANVALRAPAILGATAFFGSLSLLASLVEKDGKWQHRIAQRWARACVAASGGRLTVLHGERLKPQVAVYACNHLSYMDTPVIFSTLPFQFRIVARHDLWKLPFIGWHLERSGQVPVNVDNPRASIASLSSAVRTLKSGMPLFIFPEGGRTRDGHLAPFLNGPAFMAIRAQVPIVPMALIGTHELLPIHAGQLHAVPVTLVVGEPIETSGYSMKQVNELTARLYAAIADLYYGHTYLPRPAVESPVLQEATESHN
>NC_012483.1|WP_015897268.1|2535864_2537199_+|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase
MTTIRAVEANAKDRLFALAAELGDARRKFRLEEMRTLCEALGRPERRFASVLIAGTNGKGSTAAALASIVSEAGYRTGLYTSPHLESVNERIRIGGEMIDDEAFSRAFAQVEAAAGKLQQEGRLPQPPSFFEAVTATAFVAFAEAGIEIAVLEVGMGGRLDATNVVEPLISVITDIALDHMEYLGSTISAIAREKAGILRPNGTLVTLPQHPEANQSIGEVATALGARGVNAAIYLPFLDPTQAGAHNRYPLTVLEETIEIDAPLEGAHQQRNLALAIAAAAELRNHQGYKIDAQQIARGIHATRWPGRFELVRQQGRADVLLDVAHNPAGAWALRSALAHLEPAPASMTLVFGCLRDKALDEMAQILFPIFDRVVLAAVDSPRAATMESLREAAATVQADALEAADPAAALETAWEITPQEGLVVVAGSVYLVGALRKKAISA
>NC_012483.1|WP_015897267.1|2534846_2535515_-|cytochrome-c
MANGRAGFWRGVLWVILLEVLAGLGFYLFVSLGGLPMTADAQPGALETWAAHVSMHGWLGHHVPHVPDTVAVNDQTLMHGAALYQANCAVCHGGANYAPSELRNGVYPGAPQFVHVNQEGHGEHHGGHHGHKGPDDFGYYIIKHGIRFTGMPAWKYSMSDDDIWSVVNFMQNMDHLPPDVQAAWQKMPMSPIAPQPASMQMNSTPSGGSGSPTASSSGSPAK
>NC_012483.1|WP_041839489.1|2532672_2533053_-|DUF2752-domain-containing-protein
MQIRSAIPRAARLHTVMLCLLVLATALLCFRPEWVLGLGLHCGLKTLFGLKCPFCGMTRDFAAMLHGHRPALNPASPFMAFVIYGVYPVAVATAWRRRRFDWFSKPVVHRALAVCLLAMFLLNNLV
>NC_012483.1|WP_015897264.1|2532379_2532664_-|hypothetical-protein
MSFAFGFAIVIVIAIFVYTDAQKRGMNAFLWALGTLLFCIVFFPLYLILRNPVVLVLPPGVPGPVSTGPRLCATCGKYYEGAAQFCPHCGARQG
>NC_012483.1|WP_041840184.1|2530885_2531872_+|AAA-family-ATPase
MITIAFFNNKGGVGKTSLVYHLSWMFAGRGKRLISVDLDPQANLTSMFLDEDRLEELWPDGRHPLTIDGVIEPIRRGKGDLAEPHVETILPNLGLLAGDLSLSTFEDKLSAAWPLCHNREEAAFRTMTAFYRAIRQAGDKADAEIALIDVGPNLGAINRAALIASDYVVVPLGSDLFSLQGLRNLGPRLHDWRKTWQELRTKNPDPELLLPSGNMRPVGYVSMQHATRADRPVQAYRRWMDKIPAEYRRSVLAEPADGDVSVERDQHCLAMLKHYRSLMPMAMEAHKPIFLLKPADGAIGAHVYAVRDCYTDFDNLSRKIQQAVGIES
>NC_012483.1|WP_015897262.1|2529704_2530889_+|putative-DNA-binding-domain-containing-protein
MIDQDKVLELCRDLESDHVERTTTTRDTDKFAKAVTAFSNDLPGHGFSGYLLVGVKDDGALSGLTVTDELLRTLGSLRDDGNILPAPAINVAKFSFPEGDVAVVEVIPSDLPPVRYKGQVWIRTGPRKGVANEQEERILTERRIAHARTFDAQPARDSSIEDLSIDLFRSNYLTQAVAREIIQENHRSIEHQLASLRFYDQKRMCPTNAGILLFGKNPLQHLPGAYIQFLRVQGTTLNDEILTERSISGDLLTVLRELDLLIKIYLDQKPFSISPLREEMIVSYPEVALREFLMNAVLHRSYESTAPIRFYWFEDHIEIQNPGGLYGEATRENFPQQNSYRNPIIAEAMKTLGFVNRFGRGVIRAKDVLAKNGNREPDFTFDPNYVGVTVWAKP
>NC_012483.1|WP_015897261.1|2527662_2529708_+|threonine--tRNA-ligase
MEKQIQVTLPDGTVKTFPAGTTPFQVAESISPRLAQAAVVARIQTTQPAAATVTAGSEADSKTASEAAMYSAADPGAPRLVDLSTPLEEDVQLALLTEKDPEALKVLRHSAAHLMATAVLELFPETKLGHGPATDAGFFYDFYRPTPFTPEDLKLIEGRMAEIAQRNDKFVREFIPREEGLAEFKAGDDFMKVHFIERFTQPGEAISLYRNGNFVDFCRGPHVPSTNRIKAFKVTNLAGAYWLGDEKNPQLQRLYGTAFFSKKDLDEHFARLEEIAKRDHRVLGKQLDLFSIQEIAGAGLIFWHPKGAMIRKIMEDWMREECIRRGYDLVYTPHVMRVQLWKTSGHEGFYSQNMFTPMELDDAEYRLKPMNCPGHILIYKSQPRSYRDLPVRYAELGNVYRYERSGTMHGLLRVRGFTQDDAHIFCTPEQIEDEVVACIDFAQSVLTTFGFMDFQVELSTWDPNDRKNYAGSDDKWNLAISSLESALTRKGIAYKTIAGEAAFYGPKIDIKLVDVLGRLWQLSTVQFDFNLPARFELEYVGEDGERHQPVMVHRALYGSVERFFGVLIEHYAGAFPLWLAPVQIGLVPISERHLAYAEKVQQQLEAAGFRVELDRRNEKMNAKIRDFTLQKFPYVLIMGDKEAEAGAVSVRTRGKGDQGSLPLDEFIGRATTLIDTKSGDL
>NC_012483.1|WP_041840183.1|2527068_2527566_-|tryptophan-rich-sensory-protein
MTKRSPRLGALAVWLLVCYAVAALGTVPTTHAVATWYGSLAKPAHTPPNWVFGPVWTLLYTLMAVAVWLVWESPASYLRTRSVFRFWVQLGLNLLWSYLFFGGGHLLGGLIDILALWLMVLIVTVHFWHVRKWAGALMIPYLLWISFAAYLNWGVWQLNPGFVLP
>NC_012483.1|WP_015897272.1|2539851_2540703_+|ParA-family-protein
MSKVLAVVNQKGGVGKTTTAINLSAALALEGLPTLLIDCDPQANSSGGLGIARDDERKSTYDVLIGECTLEEATLPTEIPTLSVVPSSKNLIGANVELIQQEQRAFKMKQALDAVREKYTYILLDCPPALDLLTLNSLVAADGLLVPMQAEYFALEGISELMHTLERVREAFNEKLQIEGVLLTMYDDRTNLAQQVTENLRGFFQEKLFQTTIPRNVRLAEAPSYGKPVALYDPRSRGAETYQALALELLGRHGIESPAAKEREKAAKANKDRPAIRFWPYSK
>NC_012483.1|WP_015897273.1|2540781_2541714_+|ParB/RepB/Spo0J-family-partition-protein
MTAPDQAKDSAKRRALGKGLESLLPRVQAKAEPEAPKAGITAPVFEVGKPREIPVGEIERNPWQTRTHFDEEQLAELTASITATGVVQPILVRTLPTGRFQLIAGERRWLASQRAGKETIPAILRQVTDQQAMEMTIVENLQRTDLNPMEQARAYERLGREFQMTQEQMAKRTGKDRASVSNFLRLLKLPGEVQAKVESGDLSFGHARTLLALEDPESIQKAAQKVLALSMSVRQTESYVQGILHPERKQAKGGEEKKPAIDPNVREAQDQMQRALGLRVRIEDKKGRGRVIIEYSGLEDFDALLEMLTK
>NC_012483.1|WP_015897274.1|2541783_2542941_-|glycosyltransferase
MKILHAIQSLSPADGGPPQAVRNLMRAYASLGVEGEVFCLDTPGTEFLNEVAAPVHALGPRRGGFGYSSTIPHWLNAHLPAYDALVLHGIWNYTNVAARRTMLKLKRPYAVFPHGALDPWFNRQYPLKKLKKQIFWPWQYPVLRDAKAVLFTSTTERDLAATSFQPSRWNALPVPYGAMEPEDNPAAQTAAWFQHAPSLVVDGRPRRYLLFLARIHEKKGCDLLLQAFAHIAASAPDLHLVIAGPDQVGLQAKLQQQAAQAGIADRVHWPGMLRGDVKWGALRHCEAFVLPSHQENFGIAVAEALACGKPVLISDQVNIWPDIEADESGLVEKDTLEGTCKLLERWLALNPSQREAMVSRALPCFRKRYSMQETARAIRDLFSTP
>NC_012483.1|WP_015897276.1|2543021_2543528_-|DUF4112-domain-containing-protein
MPPVTQPDVLSPLRTRSRAARWLGDEQLDLLARLLDEWFRIPGTSIRIGLDGLIGFIPGIGDVLAGLTSLLLIGAAWLRGVPYATLARMSINVGLEVLIGSIPLAGDFFIVAFKANRRNYRLMTRQLAEPRRHTWKDRCFLALAALSLALIFAAPILALAMLLRWWLR
>NC_012483.1|WP_015897277.1|2543781_2544504_+|DUF72-domain-containing-protein
MARHSLYAGCSGWAYASWKPGFYPAKTAAKQFLAYYASQLNSVEVNYTFRQLPSAAQAENWLAATAEDFRFSFKAPQRVSHLLRLRNCGEAMAAFADSVAPFAQAGRMGLVLVQLPPNFRADAARLAGFLEDASRLNLRLALEFRHESWFETATYATLERHGAALCIAESDELVTPEVHTTAFACYRLRRSQYDEAALDELAERLHKGAASGDVYAYFKHEEAPDGPLRAMAVRKRFHEL
>NC_012483.1|WP_148215273.1|2544585_2545650_+|alpha/beta-fold-hydrolase
MIAPTMSDAAVAWEPRFVPRRFLRNGHLQTLAGNFLPRKQTLPEPESLLVEVEGPVAGYGPTQVLCHCHWQPEDVRRVRLTVVLIHGLEGSSNSQYVVGNTARALAAGCNVVRMNMRSCGGADHLSPTIYHSGRSGDVARVLERIVDEHALEQVALVGYSMGGNMALKLLGEYGVAPPPQLKAVVGISPLMDLTPSSAALHEPANRIYEWHFVRALRRRLRYKSQLFPRLYPAELAGQLRTMRDFDNHAVARYGGFRDADDYYVSVASSQYAAEFRVPTLILHSLDDPFIRMLPTTRAALLANRWVSYVETQHGGHCAFLSPADRKQPQPDFAHDGYWAEHLLLRYLLEQARGS
>NC_012483.1|WP_041839490.1|2545639_2546224_+|hypothetical-protein
MEADWSVELGEGLPEIVIPWSGEGLQWVDLRATHADCKAAVSDLALAEARAPLAEALNALNAERSPWLTSKCDAWLIDGEDEALDPYELDAADLAATGSPLHGCASYLDLLARGAETFCDFKKQEALLCALAQALREVPLPHARIDLVLRGARMHQQEGFGMTAYVTGCGLDAAAALQAWQGALAAMTHALLNC
>NC_012483.1|WP_041840187.1|2546253_2547240_+|alpha/beta-hydrolase-fold-domain-containing-protein
MRKLTLLLLACAGFLAMTASAPAQTVSAQGLPKPMPLYQGTPPGALGNKPQDIPELYVMLPKKPTTSAAVLVIPGGGYEFVALGHEGFQIGEWLRAQGMPAIVLDYRVAPYHYPVEIEDGMRAMRVIRAHAKEWGIDPNRIGVWGSSAGGHLASTLGTHCNKMNPNAADPIDRLSCKPDFMVLAYPVISMRKSITHMGSRNALLGKNPSPALVKKYSNELQVSPSTPPTFLFATERDPVVPIHNSIDFYNAMIRNGVPGELHIFDYSNHGCGLCGSIIPLRAWPGLLRQWFIDRSLLPPNAPPPPPPAPNLPDWMPGFQGPGMTVPKW
>NC_012483.1|WP_052294782.1|2547289_2548786_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MHPIQPHPQLAEVENLAHETIVAISTPPGRGGIGIVRLSGPRAVPMAEALVRLRHPLQHASARFAEIYEPSAPGEPAAEGTSEAPRKLDEAVVTCFQAPRSYTGEDLVEIAAHGSPVVLQMLVRAALAQGARLARPGEFTERAFLSGRLDLTQAEAVRDLIDAQTLYQARVAAEQMGGALSRRVQPAKQQLVELIALLEAGIDFAEDDVDVTPNAQILTRIDAMQPILESLHRSFARGRLVHSGLTLAIVGRPNVGKSSLFNRLVERERAIVTAMPGTTRDLVSERVSLGGIPLELVDTAGLREGADEAETIGIQKSREALADAHLVMLVVEGNTPLSEEEQALAASLAGRRALLVRNKSDLVQQKSLLDTQPEALFASPPEASSEKESETVTNIRAVSTSALTGEGIAGLRETLLQMMQAEGMGSESGMLTSLRHHEAVSAALAALGKARAAAQAGIPHEMVLLDLYEALRQLDSLTGETTADDILNRIFSTFCIGK
>NC_012483.1|WP_148215122.1|2548814_2549375_-|single-stranded-DNA-binding-protein
MPIEDYQGAAQTIASFLKMLTTQGGLRLKYRITAGAGAADPHGLEAREIYVELAGPDASLLTQRGGELLRALEHVAAKMIRLENEEHDRVSFDSNNFKALRAQELKLAAQTAAERVRETGQPYAFAAMSSRERRMLHLALRDYEDLETSSSGEGLNRFVVAYPKGYDHHKFAPRVPAVRGGGRGRR

Crispr_ID: NC_012483_4

• CRISPR_ID: NC_012483_4
• CRISPR_location: 2842092-2842179
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of NC_012483_4

Consensus_repeat	Method
AAAACACTGGGCTTTGGCCCCTGA	CRISPRCasFinder

spacers of NC_012483_4

>4.1|2842116|40|NC_012483|CRISPRCasFinder
AGGGTACGGGCTTCAGCCCGTACATCCAGATCTCCACTAA

CRISPR arrays and Neighbor proteins around NC_012483_4

CRISPR arrays

The CRISPR arrays of NC_012483_4

>merge|NC_012483|4|2842092-2842179|CRISPRCasFinder
AAAACACTGGGCTTTGGCCCCTGAAGGGTACGGGCTTCAGCCCGTACATCCAGATCTCCACTAAAAAACACTGGGCTTTAGCCCCTGA

>NC_012483|4|3|2842092-2842179|CRISPRCasFinder
AAAACACTGGGCTTTGGCCCCTGA	AGGGTACGGGCTTCAGCCCGTACATCCAGATCTCCACTAA
AAAACACTGGGCTTTAGCCCCTGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_012483.1|WP_015897528.1|2831917_2833846_+|AI-2E-family-transporter	unknown	unknown	gnl|CDD|223701
NC_012483.1|WP_015897545.1|2851927_2852986_-|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
NC_012483.1|WP_015897530.1|2836271_2836976_+|DUF4397-domain-containing-protein	unknown	unknown	gnl|CDD|379570
NC_012483.1|WP_041839528.1|2834085_2835765_-|RNA-polymerase-sigma-factor-RpoD	unknown	unknown	gnl|CDD|235549
NC_012483.1|WP_083770681.1|2831389_2831650_-|NINE-protein	unknown	unknown	gnl|CDD|377473
NC_012483.1|WP_015897541.1|2848386_2849475_-|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada	unknown	unknown	gnl|CDD|185333
NC_012483.1|WP_015897532.1|2838403_2839687_+|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238868
NC_012483.1|WP_015897537.1|2842422_2844072_+|CTP-synthase	unknown	unknown	gnl|CDD|235437
NC_012483.1|WP_148215287.1|2847115_2847370_+|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|378968
NC_012483.1|WP_015897533.1|2840146_2840527_+|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_015897538.1|2845372_2846650_-|adenosylhomocysteinase	unknown	unknown	gnl|CDD|240619
NC_012483.1|WP_015897534.1|2840850_2841906_+|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_015897543.1|2849921_2851226_+|adenylosuccinate-lyase	unknown	unknown	gnl|CDD|176464
NC_012483.1|WP_015897540.1|2847477_2848227_+|glucose-1-dehydrogenase	unknown	unknown	gnl|CDD|187620
NC_012483.1|WP_015897526.1|2829754_2831308_+|cytochrome-b-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|224209
NC_012483.1|WP_015897525.1|2829155_2829767_+|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl|CDD|239553
NC_012483.1|WP_015897544.1|2851222_2851813_+|UbiX-family-flavin-prenyltransferase	unknown	unknown	gnl|CDD|223241
NC_012483.1|WP_148215136.1|2837101_2838343_+|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238868
NC_012483.1|WP_012680514.1|2844177_2845110_-|IS481-like-element-ISAcp2-family-transposase	unknown	unknown	gnl|CDD|366234
NC_012483.1|WP_052294795.1|2849561_2849804_-|DUF2007-domain-containing-protein	unknown	unknown	gnl|CDD|378182

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_012483.1|WP_148215287.1|2847115_2847370_+|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	8.9e-11	36.9	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_012483.1|WP_015897545.1|2851927_2852986_-|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.16399e-15
NC_012483.1|WP_015897530.1|2836271_2836976_+|DUF4397-domain-containing-protein	gnl|CDD|379570	pfam14344, DUF4397, Domain of unknown function (DUF4397). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 120 amino acids in length.	3.84818e-18
NC_012483.1|WP_041839528.1|2834085_2835765_-|RNA-polymerase-sigma-factor-RpoD	gnl|CDD|235549	PRK05658, PRK05658, RNA polymerase sigma factor RpoD; Validated.	0
NC_012483.1|WP_083770681.1|2831389_2831650_-|NINE-protein	gnl|CDD|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	8.40501e-10
NC_012483.1|WP_015897541.1|2848386_2849475_-|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada	gnl|CDD|185333	PRK15435, PRK15435, bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada.	9.16865e-109
NC_012483.1|WP_015897532.1|2838403_2839687_+|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.1033e-106
NC_012483.1|WP_015897537.1|2842422_2844072_+|CTP-synthase	gnl|CDD|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NC_012483.1|WP_148215287.1|2847115_2847370_+|metalloregulator-ArsR/SmtB-family-transcription-factor	gnl|CDD|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	1.42466e-13
NC_012483.1|WP_015897528.1|2831917_2833846_+|AI-2E-family-transporter	gnl|CDD|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	6.64467e-46
NC_012483.1|WP_015897538.1|2845372_2846650_-|adenosylhomocysteinase	gnl|CDD|240619	cd00401, SAHH, S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains. S-adenosyl-L-homocysteine hydrolase (SAHH, AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and Hyc is sufficiently fast, so that the net reaction is in the direction of hydrolysis. Since AdoHyc is a potent inhibitor of S-adenosyl-L-methionine dependent methyltransferases, AdoHycase plays a critical role in the modulation of the activity of various methyltransferases. The enzyme forms homotetramers, with each monomer binding one molecule of NAD+.	0
NC_012483.1|WP_015897543.1|2849921_2851226_+|adenylosuccinate-lyase	gnl|CDD|176464	cd01360, Adenylsuccinate_lyase_1, Adenylsuccinate lyase (ASL)_subgroup 1. This subgroup contains bacterial and archeal proteins similar to ASL, a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASL catalyzes two steps in the de novo purine biosynthesis: the conversion of 5-aminoimidazole-(N-succinylocarboxamide) ribotide (SAICAR) into 5-aminoimidazole-4-carboxamide ribotide (AICAR) and, the conversion of adenylsuccinate (SAMP) into adenosine monophosphate (AMP).	0
NC_012483.1|WP_015897540.1|2847477_2848227_+|glucose-1-dehydrogenase	gnl|CDD|187620	cd05362, THN_reductase-like_SDR_c, tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs. 1,3,6,8-tetrahydroxynaphthalene reductase (4HNR) of Magnaporthe grisea and the related 1,3,8-trihydroxynaphthalene reductase (3HNR) are typical members of the SDR family containing the canonical glycine rich NAD(P)-binding site and active site tetrad, and function in fungal melanin biosynthesis. This subgroup also includes an SDR from Norway spruce that may function to protect against both biotic and abitoic stress. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.01077e-89
NC_012483.1|WP_015897526.1|2829754_2831308_+|cytochrome-b-N-terminal-domain-containing-protein	gnl|CDD|224209	COG1290, QcrB, Cytochrome b subunit of the bc complex [Energy production and conversion].	2.4513e-64
NC_012483.1|WP_015897525.1|2829155_2829767_+|Rieske-2Fe-2S-domain-containing-protein	gnl|CDD|239553	cd03471, Rieske_cytochrome_b6f, Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium, contains four large subunits, including cytochrome f, cytochrome b6, the Rieske ISP, and subunit IV; as well as four small hydrophobic subunits, PetG, PetL, PetM, and PetN. Rieske ISP, one of the large subunits of the cytochrome bc-type complexes, is involved in respiratory and photosynthetic electron transfer. The core of the chloroplast b6f complex is similar to the analogous respiratory cytochrome bc(1) complex, but the domain arrangement outside the core and the complement of prosthetic groups are strikingly different.	5.65096e-13
NC_012483.1|WP_015897544.1|2851222_2851813_+|UbiX-family-flavin-prenyltransferase	gnl|CDD|223241	COG0163, UbiX family flavin prenyltransferase [Coenzyme transport and metabolism].	1.34206e-74
NC_012483.1|WP_148215136.1|2837101_2838343_+|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.36707e-92
NC_012483.1|WP_012680514.1|2844177_2845110_-|IS481-like-element-ISAcp2-family-transposase	gnl|CDD|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	7.3784e-26
NC_012483.1|WP_052294795.1|2849561_2849804_-|DUF2007-domain-containing-protein	gnl|CDD|378182	pfam09413, DUF2007, Putative prokaryotic signal transducing protein. This is a family of putative prokaryotic signal transducing proteins of Pii-type.	1.09448e-07

Protein sequences

>NC_012483.1|WP_015897534.1|2840850_2841906_+|hypothetical-protein
MRLSSVLLLCGLVAAVPALSTQSLSAQTTSAPNTGTTTASPAPQATGNSASTSQNSAPAAPLKLESLPPEPHTLTPAQIARLREQRILEATTQLARNEAAWGPARSTPGTSLDMVEAGRKSTPQGLQITYTFQVKGFKSTDNLRLIQWPLDENLKVLNTGLSLDGQGQLICPAITQGDCLSSMQPGDAVKFAATAARGEALRLAVFDDTTKQHAETTVIPFPLLYTGKSCQLEAMLGVKNAALVLLEGVGFPASKTIQIQAATNGENRAVSTTTSAKGQLLAAFMPVVANKTSGTTTLSYDGGPGCSPSLSFPWGEGSYHAVTQAEAATPQAAAPATKPTPAHSATLHKKH
>NC_012483.1|WP_015897533.1|2840146_2840527_+|hypothetical-protein
MSRYRFYSREQVELLPPSVHEVVGRDHVCFLFMGWWSVWIYAGFMRSTLPKVIAAQRVTQAVNDNAGLLPMDDQVQRRCGSPPERVLADSGLFSAANLEDLENRNIEFTLAALAWHLTRLHLGKQN
>NC_012483.1|WP_015897532.1|2838403_2839687_+|SGNH/GDSL-hydrolase-family-protein
MRAGDFSKEDGLVNLLRRISCGAFWIALASLTSTAVAQTPRNLHWTDSWAASPMQQTFYTSNTAFHDTTVREIVHLSRGGHYVRVRLSNVFGTEPLHITAVHVAAAVATNSSQIVAGTDTPVTFQGSADVLIPPGAAYVSDPVAFDAKPLENLTVSFHVNEPSMPETFHDNANQVAFMAPGDQVGATQLTHARSELHWYWLTGVEVGTPQPGSCVVAFGDSITDGWQSTVNGNNRWPDDLAARLQAHAATKNVCVVDEGISGNRVLLDGSGPNAMSRFDRDVLSQPGVKYVIVLEAINDIGHLADQQDVSQADQEALYHHLIAGYQEMIDQAHAHGIKIIGATLTPFKGCGYYTAQGPEFEALRQKINTWIRTPGHFDAYVDFDKATRDPAQPDRFAPEYDSGDHLHPNPAGYKAMANAIPLTLFEK
>NC_012483.1|WP_148215136.1|2837101_2838343_+|SGNH/GDSL-hydrolase-family-protein
MKCFLLLLLAAAVSASAQTASSLPPGTHWVGTWASSQQIPEPRNTLPVADLTDATVRQIVHLSLGGDELRIRLSNAWGMRPLTFTAVHIAEPVALDSSAIVPATDTEITFGGQASVTIPAGAEYVSDPVHFDAKPLSSLAITFYLKQPPARETSHPGARATTYYVHGDQVSAPELKDAGTVDHWFEISGVDVAAPRKDACIIALGDSITDGHATEDNKNQRWTDDLAARLQAHRQTRNLCVLNEGIGGNRLLQYGLGPAAAARVDRDVLAQAGARTVILLEGVNDIGVFGFHKNATAADHHALVERMIEADRQIIERAHEHGLRILGGTIMPFKGSGYYHPGPQEEADLAAVNAWIRTPGHFDGVIDFNKIMRDPAHPLRLNPKYDSGDHLHPGPAGYVVMANSIPLKMLEAK
>NC_012483.1|WP_015897530.1|2836271_2836976_+|DUF4397-domain-containing-protein
MSLRKSRYLAAALAVAATVGVLSGCQSVAGSQAVSLVRVIDASYNAPAVDVYVGQTQIAGNIAAPFISNYAILSPGVQTTKIDSTGTTKVLATVSGNYLASTQHSLYLSDSGTSFTATLLTDQVTAAPAGDFDVRFLQNANAVGSVDIYLVPDGSKFAAATPIAANLAPGQVTSYIPVAAGSYQLVIAPAGSTKASYTGSAVVYASGQVRTLLITDQPNVDQQPINVVVGDDVD
>NC_012483.1|WP_041839528.1|2834085_2835765_-|RNA-polymerase-sigma-factor-RpoD
MALDDKYEEDLQKLIDAGKEKGYLTYNEVNDLIPGDMTSPEDLDDLMTTIGTQGIDILEGSPKLGNDGFDDEDSDDVELDLTPGTLEKTNDPVRMYLREMGTVPLLTREGEVEIAKRIERGQLRVMKAVSRSPIVIREIIALGEDLRRGVRSVKEVVIFDEEEITEEVLAARVRQTANKIDGIVKHQKKIQALEEKMQAAKSKVKEQRKLRWLIAREMVFITRIVRDLKYTNQERKRLLDKVNKTVDSMRTLERQIRSLDQKYDQSKSEELKKEYRRQQKNCKTDLEKLEEEAGLSIADLKRTQREIIQGDMDAEQAKRELIEANLRLVVSIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRAIADQARTIRIPVHMIETINKLIRTSRQLVQELGREPTSEEIARRMDIPVAKVRKVLKIAQEPISLETPIGEEEDSHLGDFIEDSQAVSPSEAVISVNLKEYTSQVLRTLTPREERVIKMRFGLEDGSEHTLEEVGQSFQVTRERIRQIEAKALRKLRHPSRSRKLRAFVDNAREM
>NC_012483.1|WP_015897528.1|2831917_2833846_+|AI-2E-family-transporter
MATETASRTRKALFDSHPAWMLALVIAALYFGRDIFIPLAMALILSFLLTPLAERVEHRLHLRRTPSVILVAIVAFGCMAIIGWVVAAQLLTVVDALPNYRDNIQAKIDAIHAPAKGPVAQAVRSIQEISNALSSGAPQPAPAPEVQLPSFRRMTRADLEKEILRLQAESQANTNKGPTPVMVVSPPVSETAYLGTILLPVVKPLGILAAMLVFTVYMLLRREDLRNRVLLLAGVGHINVMSQALNDAAERISRYLRMNVLVNAGFGAVVGIGLYLLHVPNATLWGVLVGLMRLVPYFGIWAAGSVTFIFTLAVFPGWWHPLFVAMMLVAIELLISNFFEPWFYGSHTGVSSLALLVSAIVWTILWGWAGLILSTPLTVCLIVIGQHIPQLRFLQILLGDDAELEPEAALYERLLAMDQAEARTIAYQYLEERSLLELYDSVLLPALVLAEQDRHKGDLDEVRTTYVHQSIAEIIAEVAEHKPAWPPSLEAVMQRAPALRCGPVVCVAASDYADELAAGMMAHLLERAGRDTLLLPSNALSPEILERLAQEKDTVLCLSALPPFAFAHARALCLQLRQQMPDQRIAVGLWSEQEDQSEMVVRFGKAAPSTVFFTMREAMTYLLGCENPRPAQMMPESSATGV
>NC_012483.1|WP_083770681.1|2831389_2831650_-|NINE-protein
MVQKDELLGALLALFLGTFGAHRFYLGETTAGILYILFCWTGIPTLLGIIECFFMPSRVRTWNLNHAMQISAWVRGQMPSPAVYKY
>NC_012483.1|WP_015897526.1|2829754_2831308_+|cytochrome-b-N-terminal-domain-containing-protein
MRGLDKAKKVYDWLEFRVGFEKPVKEAALHPVPRNTASWWYVFGSAAFTLLMLQVFTGILLALIYVPSAGQAWQSLNFINHDLTLGWFVRAVHNWGSNFMVAIVLIHMVQVFLFGAYKFPRELTWMVGVFLLLLTLGMAFTGQVLRFDQDAYWGLGIGVSITGRVPFIGGQLVHLLLGGPIIGGATLSHFFDLHVFIMPAALLGLAGLHVWMVLRLGINEWPMPGRMVKRTTYMKEYHELTHTDGVPFVPVALWKDIVFSGAIIAAVLVCAAILGPKGPGGAPNPTYIRTAPKPDFFFLWIYTALAMLPPWMETPLLLTAPIIGIVGLLSVPLIASEGEKSWHRRPVAVLTVALVAVAWGTLTHLGTYEPWSPHMNAWSKDTMPVKFVHQDSPLERRGAVVFQEKQCRNCHEIAGEGGHRGPALDDVATNMTQDQLIRQVLQGGGNMPAYGKNLTPPQVKALIAFLETLHGPNQKPAMDASQHFDESLVHTGVTVPAQTMPFAPPAGSGSQNSDPMK
>NC_012483.1|WP_015897525.1|2829155_2829767_+|Rieske-2Fe-2S-domain-containing-protein
MTEETGTHSEPSDYSQHSATNDQLSISRRWLLLKIGVAFNAVVGLVLATPIIGYLLAPMKKDRAYKSWVSLGGIEKFPVGQTRLATYVNPWKSPSDGQTDDIPCWVQRRTKTEFTVFAINCAHLGCPVRWFPQSQLFMCPCHGGVYYADGSVAAGPPPRGLFKYQSKIVGGDLQIFAGQIPTLSNTAQLVNIGGCKGDSPCAG
>NC_012483.1|WP_015897537.1|2842422_2844072_+|CTP-synthase
MSAKYIFVTGGVVSSLGKGLAAASIGCLLEARGLRVNLMKFDPYLNVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFTHARLTRDNNLTTGRIYEQIITKERRGDYLGKTVQVIPHVTNEIKNAMRKVAADGDVTIVEIGGTVGDIESLPFLEAIRQMRQELGRENTVFVHVTLVPWISAAQELKTKPTQHSVKEMLSIGIQPDILLCRTDRYLPHDIKSKIALFCNLEEKAVITAKDVDSIYEVPLVFAQEGVDKLALRYLHLDTREPDLSRWSALVERCYHPTGEVSIGIVGKYVEYEDSYKSLKEALVHGALAEGLKLRVTWIEAEGLEAPNYEQQLSGFDGILVPGGFGKRGVEGMLNAIRYARENKVPYFGICLGMQTACIEFARNVCGLQGANSSEFDPATPHRIIYKLRELTGVEEMGGTMRLGAWACVLQNGSLAADAYGKTEISERHRHRYEFNREYEAVLTGAGLRISGTTPDSTYVEIVEIPDHPYFLGCQFHPEFKSKPLEPHPLFHAFVKAAYQNHKPHTEATQPAAESAPIGK
>NC_012483.1|WP_012680514.1|2844177_2845110_-|IS481-like-element-ISAcp2-family-transposase
MDIHQNARLTPYSREQLARKVICTGCTLKLAAASFNVSAKTAGKWVRRYRAEGSDGLRDRSSRPHRSPRRLPEALRLSVIELRRGYMPGYQIARRSAVSVSSVSRILRRARLSRWRDLNPPPPVVRYEHAAPGDLLHLDIKGMTRFGEVSLRGDGRLRGKKEHPGFLALHVAVDDHSRMVFAQMLADQKAETTIGFLHAAVEFFASHGIGIRALLTDNGSSYRSRQFRQACQQMAIKHSRTRPYTPRTNGKAERFIQTAMREWAYAKHWTDSSQRDQHLQSWIHYYNHERPHGSLNYKPPSSRSQEGTTS
>NC_012483.1|WP_015897538.1|2845372_2846650_-|adenosylhomocysteinase
MATTSIPTSHHVKNLDLADQGRKRIEWANQSMPVLQSIRKDFIKNQPLKGLRISACLHVTTETANLMITLRDGGADVALCASNPLSTQDDVAASLARDFNIKTYAIKGEDNDTYYSHILAAIDHKPQVTMDDGCDLVTILHTKRKDALEGVIGGTEETTTGVIRLHAMAKEGVLNFPVVAVNDALTKHMFDNRYGTGQSTIDGIVRSTNVLLAGSKFVVAGYGWCGRGLASRARGMGADVIVTEVDPTRALEAVMDGYRVMSMAEAAKIGDIFCTVTGNKSVLRQEHFEAMKNGAIVANSGHFNVEIDIPALARLASSKRAGREFVDEYALRDGRKIYLLGEGRLINLAAAEGHPASVMDMSFANQALAAEYLVKNHANLEKKVYSVPVDLDKRVARLKLEAMGIGIDRLTPEQEEYLASWSEGT
>NC_012483.1|WP_148215287.1|2847115_2847370_+|metalloregulator-ArsR/SmtB-family-transcription-factor
MTRIAKAIGDPRRFEIFQRIAAARQQPTCGCLLETLPISAATLSHHLKELEQAGLIAVEREGKFAHLSLRRDTWAAYLKQLSKI
>NC_012483.1|WP_015897540.1|2847477_2848227_+|glucose-1-dehydrogenase
MSKLTGKVAVVTGASKGIGAAIAKALAAEGAAVVVNYSSSKEGADRVVSAITAQGGKAIAVQGSVAKSADVEKLFAETKKAYGKIDVLVNNAGIYAFSPLDQITEESFQQQFGTNVLGLLQASREAVKLFPAEGGSIINISSIVSDIAPPTSAIYTGTKGAVDAITRVLANELAPKKIRVNAINPGMVDTEGAQAAGFIGSDFEKEHTKQVPLGRIGQPDDIAKIAVFLASEDSGWLTGERLLATGGLR
>NC_012483.1|WP_015897541.1|2848386_2849475_-|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada
MPAATVSISTTQPDATEAWAEAWAAVERRDKRARGFVYAVTTTGVFCRSGCPSRRPARDNVRFFADAAAARAAGFRPCLRCRPEEAPGEAVRARRMADFLDAHRDRPVTLAELGRLTGRSPFTAQKIFRRVLGLTPAEYQRQARARALREELSRGDSVTDAVYAAGFGASSRVYASAGDVLGMRPGQFRRGGEGVVIRYWTAPTLLGEMLVARTERGICAVALGAEREGLKRELRERLEAAELREDPSLAGEIEALAQACRESPAALLDLPLDLRATAFQMRVWEALRRIPAGETRSYREMAAVLGNPKAVRAVARACASNPAALLVPCHRVVGSDGQLTGYRWGVERKRKILDLEAKQRRG
>NC_012483.1|WP_052294795.1|2849561_2849804_-|DUF2007-domain-containing-protein
MADDIVTIAEFNEPLEAEMARLRLQSAGIEVFLSGENARIMEPGLGPLQLQVPAADAEDARAILNDPGAANEAEAAEQQG
>NC_012483.1|WP_015897543.1|2849921_2851226_+|adenylosuccinate-lyase
MIARYTRPQMGQIWTEHNKYQMWMEVEAAASEVLAEDGIVPAEAARAIRERGHFSVERIQEIEAEVKHDVIAFTTAVAENIGPESRWLHYGLTSNDVVDTAQALQVKAASAILREDLLALIAVLKARALEFKHTPTIGRTHGIHAEPTTFGLKILNWYAEMRRNLVRFDAAAEQMRIGKLSGAVGTFGHLSPRHEERICAKLGLQPAPIATQVIQRDRHAQYISTLAVITATLDKIATEVRHLQRTEVREASEYFSEKQKGSSAMPHKKNPIISEQICGLARVVRSNAQAAFENVALWHERDISHSSVERVIFPDSTILTDYLLAKTTNLVEKLLVYPARMQKNLESTGGLIFSGQLLLDLAEAGMLREDAYRLVQRHAMNAWQNDLVFRELVASDPEITSRLTPEKLAKTFDLTRQLNNVDAIFERVLAGDEA
>NC_012483.1|WP_015897544.1|2851222_2851813_+|UbiX-family-flavin-prenyltransferase
MNLTVAMTGASGAVFGQTLLRVLAADARVERIHFIATESALRVLAEEMGFSGRNGLVEKLLGSPSAKITQHVENDVGAAIASGSYPSSGMIVLPCSMGTLAGIANGLAQNLIERAADVCLKERRPLLLCVRETPFNRIHLRNMTLAAEAGATIFPVIPSFYNKPVDSTEMARQFVYRVLAHLGLPQSGAYIWKPDQ
>NC_012483.1|WP_015897545.1|2851927_2852986_-|CPBP-family-intramembrane-metalloprotease
MMGRLRALGWVFLGVLYFLFAERLAVTAASGFSTGDWFPVLNRVFLLFLLLIGFAAMGFVGQRQLHPLREMGLAFRPGWFHEVLLGGAIGWSGMVACVLPMAVFGALYIQWNLSWHSVGILFLDVLTLAAASLAEEVAFRGYPFQRLIEATGPVTATVLASLAFGVMHLQNPDATAASTLVTMLAGWLLAVAYLRTRGLWVGWGFHFAWNAVMAIVFGLPLSGLTRFSPLMETSTYGPYWLTGGGYGPEGSAVAIVVLLILVVVVVTATRSLKFQYAIPPIVPGGIPVDIDEVARKQHEAAQAHAPAQPAAPTLIQIGGLPGAISRPIAPLAESPDDAGEKPEAERQGGIAD

Crispr_ID: NC_012483_5

• CRISPR_ID: NC_012483_5
• CRISPR_location: 3452305-3452400
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_012483_5

Consensus_repeat	Method
AGCCATTGTGGAGGAGATGGACCC	CRISPRCasFinder

spacers of NC_012483_5

>5.1|3452329|48|NC_012483|CRISPRCasFinder
CTCGGCGGCGGCCGACCTGCTCGCCGACCTGAGCGAAGAGCAATCCGA

CRISPR arrays and Neighbor proteins around NC_012483_5

CRISPR arrays

The CRISPR arrays of NC_012483_5

>merge|NC_012483|5|3452305-3452400|CRISPRCasFinder
AGCCATTGTGGAGGAGATGGACCCCTCGGCGGCGGCCGACCTGCTCGCCGACCTGAGCGAAGAGCAATCCGAAGCCATTCTGGAGGAGATGGACCC

>NC_012483|5|4|3452305-3452400|CRISPRCasFinder
AGCCATTGTGGAGGAGATGGACCC	CTCGGCGGCGGCCGACCTGCTCGCCGACCTGAGCGAAGAGCAATCCGA
AGCCATTCTGGAGGAGATGGACCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_012483.1|WP_015898022.1|3448552_3450016_+|trehalose-6-phosphate-synthase	unknown	unknown	gnl|CDD|340820
NC_012483.1|WP_041840349.1|3446595_3447507_-|dihydroorotate-dehydrogenase	unknown	unknown	gnl|CDD|235982
NC_012483.1|WP_083770622.1|3447728_3448556_+|trehalose-phosphatase	unknown	unknown	gnl|CDD|319767
NC_012483.1|WP_083770623.1|3456287_3457244_+|tyrosine-recombinase	unknown	unknown	gnl|CDD|274043
NC_012483.1|WP_015898019.1|3446050_3446521_+|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_041839610.1|3443272_3443947_+|ATP-binding-domain-containing-protein	unknown	unknown	gnl|CDD|238952
NC_012483.1|WP_015898017.1|3444046_3444901_+|3-hydroxybutyryl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|180269
NC_012483.1|WP_052294830.1|3463172_3463406_-|RNA-chaperone-Hfq	unknown	unknown	gnl|CDD|212463
NC_012483.1|WP_041839612.1|3455445_3456177_-|haloacid-dehalogenase-like-hydrolase	unknown	unknown	gnl|CDD|319796
NC_012483.1|WP_015898025.1|3451108_3451444_+|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_015898027.1|3452925_3454164_+|divalent-metal-cation-transporter	unknown	unknown	gnl|CDD|334596
NC_012483.1|WP_015898034.1|3461423_3461996_-|class-IV-adenylate-cyclase	unknown	unknown	gnl|CDD|143628
NC_012483.1|WP_052294829.1|3454164_3454596_-|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl|CDD|239517
NC_012483.1|WP_015898035.1|3462123_3463155_+|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl|CDD|223088
NC_012483.1|WP_015898024.1|3450448_3450889_-|ATP-binding-protein	unknown	unknown	gnl|CDD|379279
NC_012483.1|WP_015898018.1|3444971_3445958_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293819
NC_012483.1|WP_015898029.1|3454629_3455430_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238564
NC_012483.1|WP_041839611.1|3450085_3450433_-|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NC_012483.1|WP_015898033.1|3458254_3461248_+|preprotein-translocase-subunit-SecA	unknown	unknown	gnl|CDD|237259
NC_012483.1|WP_148215309.1|3457261_3458173_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|234698

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_012483.1|WP_015898022.1|3448552_3450016_+|trehalose-6-phosphate-synthase	gnl|CDD|340820	cd03788, GT20_TPS, trehalose-6-phosphate synthase. Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.	0
NC_012483.1|WP_041840349.1|3446595_3447507_-|dihydroorotate-dehydrogenase	gnl|CDD|235982	PRK07259, PRK07259, dihydroorotate dehydrogenase.	2.30018e-145
NC_012483.1|WP_083770622.1|3447728_3448556_+|trehalose-phosphatase	gnl|CDD|319767	cd01627, HAD_TPP, trehalose-phosphate phosphatase similar to Escherichia coli trehalose-6-phosphate phosphatase OtsB and Saccharomyces cerevisiae trehalose-phosphatase TPS2. Trehalose biosynthesis in bacteria is known through three pathways - OtsAB, TreYZ and TreS. The OtsAB pathway, also known as the trehalose 6-phosphate synthase (TSP)/ Trehalose-6-phosphate phosphatase (TPP) pathway, is the most common route known to be involved in the stress response of Escherichia coli. It involves converting glucose-6-phosphate and UDP-glucose to form trehalose-6-phosphate (T6P), catalyzed by TPS, the product of the otsA gene, this step is followed by the dephosphorylation of T6P to yield trehalose and inorganic phosphate, catalyzed by a specific TPP, the product of otsB gene. This OtsAB (or TSP/TPP) pathway, is also the most common route known to be involved in the stress response of yeast In Saccharomyces cerevisiae, the corresponding enzymes, TPS1p and TPS2p, form a multimeric synthase complex together with additional regulatory subunits encoded by Tsl1 and Tps3. Trehalose is a common disaccharide accumulated by organisms as a reservation of carbohydrate and in response to unfavorable growth conditions. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.46909e-45
NC_012483.1|WP_083770623.1|3456287_3457244_+|tyrosine-recombinase	gnl|CDD|274043	TIGR02225, Tyrosine_recombinase_XerD, tyrosine recombinase XerD. The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerD, one of two closely related chromosomal proteins along with XerC (TIGR02224). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and with homologs of XerD on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerD, as some apparent XerD examples score below the trusted and noise cutoff scores. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair].	3.92947e-113
NC_012483.1|WP_015898035.1|3462123_3463155_+|threonylcarbamoyl-AMP-synthase	gnl|CDD|223088	COG0009, SUA5, Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis].	1.80122e-79
NC_012483.1|WP_015898017.1|3444046_3444901_+|3-hydroxybutyryl-CoA-dehydrogenase	gnl|CDD|180269	PRK05808, PRK05808, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	4.73956e-165
NC_012483.1|WP_052294830.1|3463172_3463406_-|RNA-chaperone-Hfq	gnl|CDD|212463	cd01716, Hfq, bacterial Hfq-like. Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotropic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that modulate the stability or translation efficiency of RNA transcripts. Hfq binds preferentially to unstructured A/U-rich RNA sequences and is similar to the eukaryotic Sm proteins in both sequence and structure. Hfq forms a homo-hexameric ring similar to the heptameric ring of the Sm proteins.	1.0755e-05
NC_012483.1|WP_041839612.1|3455445_3456177_-|haloacid-dehalogenase-like-hydrolase	gnl|CDD|319796	cd02612, HAD_PGPPase, phosphatidylglycerol-phosphate phosphatase, similar to Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C. This family includes Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C, PgpC (previously named yfhB) which catalyzes the dephosphorylation of phosphatidylglycerol-phosphate (PGP) to phosphatidylglycerol (PG). This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.52952e-19
NC_012483.1|WP_041839610.1|3443272_3443947_+|ATP-binding-domain-containing-protein	gnl|CDD|238952	cd01994, Alpha_ANH_like_IV, This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily of proteins is predicted to bind ATP. This domainhas a strongly conserved motif SGGKD at the N terminus.	1.07043e-54
NC_012483.1|WP_015898027.1|3452925_3454164_+|divalent-metal-cation-transporter	gnl|CDD|334596	pfam01566, Nramp, Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.	1.03066e-87
NC_012483.1|WP_015898034.1|3461423_3461996_-|class-IV-adenylate-cyclase	gnl|CDD|143628	cd07890, CYTH-like_AC_IV-like, Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily. This subgroup contains class IV ACs and similar proteins. AC catalyzes the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. cAMP is a key signaling molecule which conveys a variety of signals in different cell types. In prokaryotes, cAMP is a catabolite derepression signal which triggers the expression of metabolic pathways including the lactose operon. Six non-homologous classes of ACs have been identified (I-VI). Class IV ACs are found in this group. In bacteria, the gene encoding Class IV AC has been designated cyaB and the protein as AC2. AC-IV occurs in addition to AC-I in bacterial pathogens such as Yersinia pestis (plague disease). The role of AC-IV is unknown but it has been speculated that it may be a factor in pathogenesis, perhaps providing cAMP for a secondary internal signaling function, or for secretion and uptake into host cells, where it may disrupt normal cellular processes. This subgroup belongs to the CYTH/triphosphate tunnel metalloenzyme (TTM)-like superfamily, whose enzymes have a unique active site located within an eight-stranded beta barrel.	1.3672e-46
NC_012483.1|WP_052294829.1|3454164_3454596_-|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	gnl|CDD|239517	cd03425, MutT_pyrophosphohydrolase, The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). This enzyme requires two divalent cations for activity; one coordinates the phosphoryl groups of the NTP/dNTP substrate, and the other coordinates to the enzyme. It also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as metal binding and catalytic site. MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides.	1.52242e-46
NC_012483.1|WP_015898024.1|3450448_3450889_-|ATP-binding-protein	gnl|CDD|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	3.86404e-30
NC_012483.1|WP_015898018.1|3444971_3445958_+|MBL-fold-metallo-hydrolase	gnl|CDD|293819	cd07733, YycJ-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis YycJ and related proteins; MBL-fold metallo hydrolase domain. Includes the uncharacterized Bacillus subtilis YycJ protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	6.65611e-38
NC_012483.1|WP_015898029.1|3454629_3455430_-|ABC-transporter-substrate-binding-protein	gnl|CDD|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	5.05527e-45
NC_012483.1|WP_041839611.1|3450085_3450433_-|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	5.18729e-25
NC_012483.1|WP_015898033.1|3458254_3461248_+|preprotein-translocase-subunit-SecA	gnl|CDD|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NC_012483.1|WP_148215309.1|3457261_3458173_+|tyrosine-type-recombinase/integrase	gnl|CDD|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	4.92387e-119

Protein sequences

>NC_012483.1|WP_015898025.1|3451108_3451444_+|hypothetical-protein
MKPRNWKLFGIALFALSTSMALAQESGRTAQNRKYEQQHRIAQGVRSGQLTGRETRHLEGREVRINHEERHMRANHDGHLTPANRARIQRQQNRTSRAIYNKKHNAAHRPY
>NC_012483.1|WP_015898024.1|3450448_3450889_-|ATP-binding-protein
MKGKEETRITYTLASSLDSVDKVEQTAEQMARQAGIDDDETFRISMAVREAAVNAVLHGNAYDPDKRITASFENTGADLIIRITDQGVGLDPATLPDPLAPENLLRGSGRGIFLIRSFMDEVHFRQLHPGTELTLIKHLGTAKPTL
>NC_012483.1|WP_041839611.1|3450085_3450433_-|STAS-domain-containing-protein
MSMKVTTRQVDGVTILDLSGRITLGEGSVQLRDAVRDLLAKGQKQILLNLGDVNYIDSSGIGELVSAFTTVHNQGGDLKLLNLTKKVHDLLQITKLYTVFDIKDDEASAIASFAR
>NC_012483.1|WP_015898022.1|3448552_3450016_+|trehalose-6-phosphate-synthase
MKEREVVIVSNRLPLSIKHDQGVAKARRSSGGLVTALLPILRDKGGVWIGNAGTHEDEHATELLQQEARNEGFACVPIYVTEQEDRNFYEGFSNQVLWPLFHDFIGECRFEPAYWEFYRKVNAKFADAVMSVYRGDQTLWVHDYQLMHVAAALRERGCKGRVAFFLHTPFPSYDVFAKLPWRRDLLLSLLQYDLIGLQTERDTRNLVSCLRRLVPEAVMTSTHTAHHVMFQGRRIVIQDFPISIDFEEFAQAAREPEVEERTRSIIARMGMGQMIFGVDRQDYTKGIPHRLRAYGALLRRRPDLVGRVRLVQIVVPSRQNIPGYEALKARIEHLVASINGEFTQPGWVPIHYIHRSIPREELLALYRAANVALVTPLKDGMNLVAKEFCATRIDDHGVLVLSEFAGAAAEMYRGALLVNPFDLEGVAGALEQALEMPLNQQQERMRKLRRFLKHANVHRWVNEFMQVIEHVNHHGSTRSNHGSARSK
>NC_012483.1|WP_083770622.1|3447728_3448556_+|trehalose-phosphatase
MTTKLSCHTLPAGWEGAPAQAKFWEMLQQSRRWLLLLDYDGTLAPFHQDRMQAVPYAGVSERLEALADRSQGRVVIISGRQIEDLKQLLPLRQPVEMWGSHGREHLDHDGSYRVVDLNPAERQVVDGLAKEMAARGWGHQLEHKPTALAVHWRGLPEEAQRSIRNAAEAYFASVQAPATLEMMPFESGIELRSRSRTKGQVVAEILAEEPDDAPAAFLGDDWTDEDGFAVLGERGLGILVRPEARESCAKFHLTPPGELIRFLDRWLEHTKESIA
>NC_012483.1|WP_041840349.1|3446595_3447507_-|dihydroorotate-dehydrogenase
MRVTVAGIEFANPVIAASGTFAYGIEFEDIVSLDRIGGFVTKGISREPMAGNAAPRLIETSAGMINAIGLQNIGVEAFLRDKLPPLARYKCAVIVNVFGYQVEDYVAVIRKLNEAEGIAAYEINASCPNTKHGGMAFGADHGALAELVAHCRHYSRRPVIVKLSPNVTSIAAMARCAESSGADAISLVNTFVSLAIDVETRQPRIRNITGGLSGPAIKPIAVRMVWEAAQAVKIPVIGMGGIATAEDAVEFLLAGATAVQVGTASYADPRAIENISHSLAHWCARRHIARVSELTGAMELPTK
>NC_012483.1|WP_015898019.1|3446050_3446521_+|hypothetical-protein
MAMKTCNDPVVGDILSSWRYDISGIVPEMRTDYEEHLATCQFCRSRQRLHRAIDVVLIGVTTLSSVLFVLALAIIHKVEPLRTFALFIFHIQHIAVVLTLQVVALAGLLVSLLAWLLVAVATPAPMYLTGVALAQARVLQARLPEEWRSRFQRGAF
>NC_012483.1|WP_015898018.1|3444971_3445958_+|MBL-fold-metallo-hydrolase
MVRMTVLASGSKGNSTLVASSRTRLLVDAGLSCREIFKRMRAMGESIEDLDAILITHEHQDHVQGLAVTARKLGIPVYFTEATHRAWMRWMTPRKRLTYAEWLEQQKAMTAAGKEPASDGDEAQDAAQEEREELTLDLAAAAQSKAELEAPEPSKPEKDPCELPGVEYFRAGADFCIGDIAVRPFTIPHDAVDPVGFVFEVEGVRLGFATDLGYIPPNVHAHLKKCDVLLLEANHDVDMLRDGPYPWSVKQRVMSRVGHLSNAAAADFLENSYDGQAAYVVLAHLSESNNMPELARVAAEQALRNHMSLLANKLLLAEQHAPLDPIVL
>NC_012483.1|WP_015898017.1|3444046_3444901_+|3-hydroxybutyryl-CoA-dehydrogenase
MSEVKRVGVLGAGTMGNGIAHVFARSGFDVRLCEVEQRFLDRGTETIRKNLGREVSKGKLSQQDADAALARIAGTLDRGALADCDLIVEAATERLEVKRQIFEDLDRIAPAGVILASNTSSISITKLAAFTGRPEQVIGMHFFNPVPVMKLVEVIRGLATSQATFDTVKALSEKLGKTPVEVNDAAGFVSNRVLMPLLNEAMYAVMEGVATPEAVDQVFQLGMAHPMGPLTLADFIGLDVCLDIMRVLLEGLGDPKYRPCPLLIRMVDAGWMGRKSGRGFFRYE
>NC_012483.1|WP_041839610.1|3443272_3443947_+|ATP-binding-domain-containing-protein
MKRKRVWLSWSSGKDSAWALHMLRQQGDVEVVGLLTTLNGHFDRVAMHSTRRALVEAQAASAGLPLVTVPLPWPCSNEQYEAAMAGACAQARDEGVEAMAFGDLFLEDVRQYRIDKLAGTGLEPVFPLWGLDTRALAEEMIAAGVKTRLVCVDPRKLGKEFAGRDLDAALLAELPPEVDPCGERGEFHSFVYAGPMFREEILIESGEVVERDGFVFADVKLRGA
>NC_012483.1|WP_015898027.1|3452925_3454164_+|divalent-metal-cation-transporter
MLKRWRTRILLFLMVLGPGFITANIDNDPNGIFVYSQAGAQYGYSLLWTILPVTLALIVVQEMCARMGVVTGKGLSDLIREEFGLRITFIMMVLLVIVNYSNVIGEFAGIAGSLELFHLTKYVSVPVCALLVWLLAVRGDYKSVEKILLTGSLFYLAYIATGILAEPNWHLSWMKTVQLPHKTEWKQNGYLLMVVSIIGTTIAPWMQFYLQSSIVEKGIRVQDYAASRADVIVGSIFTDVVAWFIIVACAGTLWVHGLGQINVPSDAAIAMKPLAGNYAFLLFAFGLFNASFFAASVLPISTAYTVCEGLGFESGVDKKFKEAPLFYWLYTILIVGGAAVVLIPHFPIVQFSIFSQALNGLLLPVVVIFMLMLINRKDLMGEHTNSHWFNVVAWVTAIVVIALSLVLVVQTL
>NC_012483.1|WP_052294829.1|3454164_3454596_-|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase
MTAQDTQPAPHRTVRYVVAALILRGEEVLVCQRRPDQPMGLKWEFPGGKIEPGETPEEALRRELNEELGIEATIGQQVAHTRHTYRNGGAVDLQFFAVHQFEGELTNRIFHDLRWTPLHTLPSFDFLAADRDLVRDLAAGKLL
>NC_012483.1|WP_015898029.1|3454629_3455430_-|ABC-transporter-substrate-binding-protein
MRLLSLQPSISVTLDALGRLDHLAACTKYCLVVVPALAGRGLPVVQDSWSARTEELLPLRPDLVLASVPYRQESLTAILKAGVPVLLLAPHSLADIYQDIRLIGSVSAAASEAEALIARMQAQIESVRHESASLPRLRVYCEEWGKPLIHSQGWVKELVEAAGAEFLGEPGSHTTAEAVAAADPDVILAAWCGAGDRVPLERIVEQRGWQRLRAVREGRVYCIRDEWLNTPAPTLLRGLAAIAQVLHPEQFDSLLPPGDLRRIKFL
>NC_012483.1|WP_041839612.1|3455445_3456177_-|haloacid-dehalogenase-like-hydrolase
MTTSTTASRYTLQEFEHEVLNLAPRVAVFDCDGTLWSGDAGYGFMTWSMDVGLLSRNASDWIDSRHRLYRHGEVSELQICGEMVQVYAGLHEDELRRAAAEYFQHHIEPQIFPELRSLVALLQARGTEIWAVSSTNNWVIEEGVRRFNIPASRVLAACVEVEDGIITSQIIDVPTDEGKAVALRRTGLPEPDAVFGNSVHDAAMLAIARRAFPVNPTPALRDLSCERGWTVYYPEAVMTDHKG
>NC_012483.1|WP_083770623.1|3456287_3457244_+|tyrosine-recombinase
MHRVWRAARHLPNNEVVTATRTTDLLRDYQSYLRVEKGLRPLSCQAYQSDLLLFAEYLESMNTALLDARSEHVAGFLEHLNTHGVVSRSVARKLSCLRGFYKWLILDKRIHRDPTINMDSPSAWKILPKSLAQEDMTAMLDRARLLAEHPEADGIALRNYAILELLYAGGLRVSELTGLRVADLSLDAGRVLVRGKGDKERLVPLGQPAVAALRQYLDRGRAELARKARGAQGALFLSARGKPLTREYVWKLVRQYGASPHMLRHSAATHMVEHGADLRTVQTFLGHADIATTQVYTHVALGHLKAVVRQHHPRGKRS
>NC_012483.1|WP_148215309.1|3457261_3458173_+|tyrosine-type-recombinase/integrase
MNQRVEAYLAALRNERGSSPHTLRAYTRELRDFAAYAERLLGKDVGVKAMEHTHIRAYLGELYERGLSKASAARALAAIRSWCKWLARHGELEQSPAALVATPKLPKHLPRVPTIEDMNRLVDASSEEVAAWPARDRLILELLYGCGIRNAELVGINLEDIQWTNEAILVRGKGRKERYVPIGDAAAQALRAYLPERNQKLATAGKDSAALLLNARLRGQGRLTTRSVGRIVKQMALAQGLPADVHPHTLRHAFGTHLLEEGADLRAIQELLGHERLSTTQRYTQLTVGQVEAVYDRTHPRAK
>NC_012483.1|WP_015898033.1|3458254_3461248_+|preprotein-translocase-subunit-SecA
MIGSVLTKVFGTSNERVVKRLLPIVEQIGALEPEIEKLSDEQLRAKTAEFRAYIAKAVEGVDDEDEQHKAIQRALDDLMPEAFAVVREAGRRVLHMRHFDVQLIGGMVLHQGKIAEMKTGEGKTLVATLPCYLNALAGRGVHVVTVNDYLAKRDAEWMGKIYEFLGLTVGVIVHDLDDEQRRQAYAADITYGTNNEFGFDYLRDNMKFDLKDCVQRKHFYCIVDEVDSILIDEARTPLIISGPTDQTTDKYVRVNRIIPALEQGEEIEKGEEKILTGDFVVDEKHKTISVTDEGWEKIEQLLGIGNIADPENWDLKHHVETAIKAHSLYKRDVQYVVKDGEVIIVDEFTGRLMPGRRWSDGLHQSVEAKEGVNIRREDQTLATITFQNYFRLYKKLSGMTGTAETEAAEFDKIYKLEIVVIPTNRPLLRVENPDVVFRTTQEKYFAVADQIAELNKNNQPVLVGTTSIEKSELLSQILVRKGVKHVVLNAKYHEREAEIVAQAGRLGMVTIATNMAGRGTDILLGGNADFMAKQELLKKGMARSISPAEGAINPMAAQGMLRFYYQGQEFETTQENWDRVFAQHSASVAQEREQVLAAGGLYIIGTERHESRRVDNQLRGRAGRQGDPGASRFYLSLEDDLMRIFAREWVSTLLQRLGMEEGVPIESRMISNRIEKAQMAVEGQNFEARKHLLEYDDVMNKQREAVYGLRNQLLAGLDQKELIVEDYVPNILSGIFDEYAPEKQHADQWNWEEIRKKLIDHFGFDYQVDGLDVADLTRHELGEEVFSRLKERYLAKEQFIGEEPMRYHERMIMLSVLDGLWKDHLLNMDHLKEGIGLRGYGQQDPLIEYKRESFDMFEAMMNRFQEDTVRYLYLMQIVGPDGQPMQVPTRLRPADASPNGVVHAEPAPLNGSAPIPEQAAPPPPPAIPTRQPSTTIDAIEREFEKKKQQELSHARMAGGGDGSDAVNTRRVGEKVGRNDPCPCGSGKKYKKCHGAEA
>NC_012483.1|WP_015898034.1|3461423_3461996_-|class-IV-adenylate-cyclase
MMAVETEVKFRVHDLAHLEQQLAAAGFHQVTPRTFEHNLLFDTPDRSLRARQSILRVRRYGDRWVVTHKAVPPGASAEDRHKHRIETETEVADGDAMGAIFTALGYAPAFTYEKWRTEYADHTGHCVIDETPIGLFAELEGPSEWIDTTAGALGLTQDNLMTLSYGRLFDEWRQQTGSEAQNLTFAEIRS
>NC_012483.1|WP_015898035.1|3462123_3463155_+|threonylcarbamoyl-AMP-synthase
MAPESANFHASIARAAEILRAGGTVAFPTETVYGLGANALDAAAVAGIFEAKQRPAWDPLIVHVSSLEMLSQVADELCDNAKRLAEVFWPGPLTMLLPRSANVPDAVTAGRPLVGVRMPSHPIAQALIEAAGVPVAAPSANSFGRISPTTAQHVAEDLEGRIDAILDGGETIHGLESTVIEPRADHSIIYRPGVVTAQQLRAVCAGSVEYYEPAHEKSAPESLPSPGVGLRHYAPRARLQLVEGAGEAQMTALRETVLDAERIGERVGVMLPESFQTALIGCAAHVYRWGRWEDKEELAQRLFAGLRQLDAEGLTLIVCPLPEAKGIGRAICDRLGKAARTHD
>NC_012483.1|WP_052294830.1|3463172_3463406_-|RNA-chaperone-Hfq
MQNASSEGSHAEAFYFQKQMQSQTPMVFMLDSGEKIEGCIEWYDRYAVKVRHARRRVLIYKSSIKYIYKAAETAAGL

Crispr_ID: NC_012483_6

• CRISPR_ID: NC_012483_6
• CRISPR_location: 3527663-3527849
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_012483_6

Consensus_repeat	Method
GGGTAAATGTGAATGCGGAATCAC	CRISPRCasFinder

spacers of NC_012483_6

>6.1|3527687|59|NC_012483|CRISPRCasFinder
ATTTCAGCGCGTTTTGGGGTGCAATTGTGGAATGAAGTTGTTGAAAATAAGCTATTTAC
>6.2|3527770|56|NC_012483|CRISPRCasFinder
GTTTTTAGCGAATTTTACGGACTTTGGCCGTCTAACTCTTTTGGATTGAGATGCTT

CRISPR arrays and Neighbor proteins around NC_012483_6

CRISPR arrays

The CRISPR arrays of NC_012483_6

>merge|NC_012483|6|3527663-3527849|CRISPRCasFinder
GGGTAAATGTGAATGCGGAATCACATTTCAGCGCGTTTTGGGGTGCAATTGTGGAATGAAGTTGTTGAAAATAAGCTATTTACGGGTAAATGTGAATGCGGATTCACGTTTTTAGCGAATTTTACGGACTTTGGCCGTCTAACTCTTTTGGATTGAGATGCTTGCGTGAATGTGAATGGAGATTCAC

>NC_012483|6|5|3527663-3527849|CRISPRCasFinder
GGGTAAATGTGAATGCGGAATCAC	ATTTCAGCGCGTTTTGGGGTGCAATTGTGGAATGAAGTTGTTGAAAATAAGCTATTTAC
GGGTAAATGTGAATGCGGATTCAC	GTTTTTAGCGAATTTTACGGACTTTGGCCGTCTAACTCTTTTGGATTGAGATGCTT
GCGTGAATGTGAATGGAGATTCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_012483.1|WP_041839619.1|3528689_3529706_-|ketoacyl-ACP-synthase-III	unknown	unknown	gnl|CDD|236475
NC_012483.1|WP_015898102.1|3536549_3537344_+|Ni/Fe-hydrogenase,-b-type-cytochrome-subunit	unknown	unknown	gnl|CDD|224880
NC_012483.1|WP_015898103.1|3537330_3537843_+|hydrogenase-maturation-protease	unknown	unknown	gnl|CDD|99873
NC_012483.1|WP_015898091.1|3526376_3526913_+|peroxiredoxin	unknown	unknown	gnl|CDD|239313
NC_012483.1|WP_015898088.1|3523579_3524995_+|glycosyl-hydrolase-family-30	unknown	unknown	gnl|CDD|227807
NC_012483.1|WP_015898092.1|3526995_3527547_+|alkyl-hydroperoxide-reductase-AhpD	unknown	unknown	gnl|CDD|129859
NC_012483.1|WP_015898104.1|3537847_3538195_+|hydrogenase-maturation-nickel-metallochaperone-HypA	unknown	unknown	gnl|CDD|376468
NC_012483.1|WP_015898097.1|3529894_3530863_+|protein-methionine-sulfoxide-reductase-catalytic-subunit-MsrP	unknown	unknown	gnl|CDD|235431
NC_012483.1|WP_015898101.1|3534809_3536546_+|nickel-dependent-hydrogenase-large-subunit	unknown	unknown	gnl|CDD|366057
NC_012483.1|WP_148215313.1|3519051_3520278_+|MFS-transporter	unknown	unknown	gnl|CDD|340886
NC_012483.1|WP_015898090.1|3525873_3526305_+|transcriptional-repressor	unknown	unknown	gnl|CDD|223806
NC_012483.1|WP_015898086.1|3521480_3522044_-|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_041839618.1|3522138_3523389_-|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	unknown	unknown	gnl|CDD|234737
NC_012483.1|WP_015898083.1|3518599_3519004_+|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	unknown	unknown	gnl|CDD|237320
NC_012483.1|WP_015898085.1|3520274_3521465_+|glycosyltransferase	unknown	unknown	gnl|CDD|213815
NC_012483.1|WP_015898100.1|3533667_3534810_+|hydrogenase-small-subunit	unknown	unknown	gnl|CDD|224654
NC_012483.1|WP_041839620.1|3530879_3531524_+|ferric-reductase-like-transmembrane-domain-containing-protein	unknown	unknown	gnl|CDD|235452
NC_012483.1|WP_169305988.1|3528080_3528248_-|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_015898095.1|3528367_3528541_-|hypothetical-protein	unknown	unknown	unknown
NC_012483.1|WP_015898089.1|3525069_3525723_+|AhpC/TSA-family-protein	unknown	unknown	gnl|CDD|239268

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_012483.1|WP_041839619.1|3528689_3529706_-|ketoacyl-ACP-synthase-III	gnl|CDD|236475	PRK09352, PRK09352, beta-ketoacyl-ACP synthase 3.	0
NC_012483.1|WP_015898102.1|3536549_3537344_+|Ni/Fe-hydrogenase,-b-type-cytochrome-subunit	gnl|CDD|224880	COG1969, HyaC, Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion].	1.35808e-36
NC_012483.1|WP_015898091.1|3526376_3526913_+|peroxiredoxin	gnl|CDD|239313	cd03015, PRX_Typ2cys, Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. The functional unit of typical 2-cys PRX is a homodimer. A unique intermolecular redox-active disulfide center is utilized for its activity. Upon reaction with peroxides, its peroxidatic cysteine is oxidized into a sulfenic acid intermediate which is resolved by bonding with the resolving cysteine from the other subunit of the homodimer. This intermolecular disulfide bond is then reduced by thioredoxin, tryparedoxin or AhpF. Typical 2-cys PRXs, like 1-cys PRXs, form decamers which are stabilized by reduction of the active site cysteine. Typical 2-cys PRX interacts through beta strands at one edge of the monomer (B-type interface) to form the functional homodimer, and uses an A-type interface (similar to the dimeric interface in atypical 2-cys PRX and PRX5) at the opposite end of the monomer to form the stable decameric (pentamer of dimers) structure.	9.9593e-92
NC_012483.1|WP_015898088.1|3523579_3524995_+|glycosyl-hydrolase-family-30	gnl|CDD|227807	COG5520, COG5520, O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane].	1.46228e-57
NC_012483.1|WP_015898092.1|3526995_3527547_+|alkyl-hydroperoxide-reductase-AhpD	gnl|CDD|129859	TIGR00777, AhpD_protein., alkylhydroperoxidase, AhpD family. Members of this family are alkylhydroperoxidases, which catalyze the reduction of peroxides to their corresponding alcohols via oxidation of cysteine residues. In these alkylhydroperoxidases, the cysteines are located in a conserved -CXXC- motif located towards the COOH terminus. In Mycobacterium tuberculosis, two non-homologous alkylhydroperoxidases, AhpD and AhpC, are found in the same operon. [Cellular processes, Detoxification].	7.38608e-54
NC_012483.1|WP_015898104.1|3537847_3538195_+|hydrogenase-maturation-nickel-metallochaperone-HypA	gnl|CDD|376468	pfam01155, HypA, Hydrogenase/urease nickel incorporation, metallochaperone, hypA. HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.	9.41727e-32
NC_012483.1|WP_015898097.1|3529894_3530863_+|protein-methionine-sulfoxide-reductase-catalytic-subunit-MsrP	gnl|CDD|235431	PRK05363, PRK05363, protein-methionine-sulfoxide reductase catalytic subunit MsrP.	0
NC_012483.1|WP_015898103.1|3537330_3537843_+|hydrogenase-maturation-protease	gnl|CDD|99873	cd06062, H2MP_MemB-H2up, Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD from E. coli is well studied in this group. Maturation of [NiFe] hydrogenases include proteolytic processing of large subunit, assembly with other subunits, and formation of the nickel metallocenter. Hydrogenase maturation endopeptidase (HybD) cleaves a short C-terminal peptide after a His or an Arg residue in the large subunit (pre-HybC) of hydrogenase 2 (hyb operon) in E. coli. This cleavage is nickel dependent. A variety of endopeptidases belong to this group that are similar in function and sequence homology. They include such proteins as HynC, HoxM, and HupD.	1.44524e-36
NC_012483.1|WP_148215313.1|3519051_3520278_+|MFS-transporter	gnl|CDD|340886	cd17328, MFS_spinster_like, Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters. The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.69196e-88
NC_012483.1|WP_015898090.1|3525873_3526305_+|transcriptional-repressor	gnl|CDD|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	6.26398e-32
NC_012483.1|WP_015898101.1|3534809_3536546_+|nickel-dependent-hydrogenase-large-subunit	gnl|CDD|366057	pfam00374, NiFeSe_Hases, Nickel-dependent hydrogenase.	0
NC_012483.1|WP_041839618.1|3522138_3523389_-|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	gnl|CDD|234737	PRK00366, ispG, flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase.	0
NC_012483.1|WP_015898083.1|3518599_3519004_+|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	gnl|CDD|237320	PRK13258, PRK13258, 7-cyano-7-deazaguanine reductase; Provisional.	2.66495e-57
NC_012483.1|WP_015898085.1|3520274_3521465_+|glycosyltransferase	gnl|CDD|213815	TIGR03469, HpnB, hopene-associated glycosyltransferase HpnB. This family of genes include a glycosyl transferase, group 2 domain (pfam00535) which are responsible, generally for the transfer of nucleotide-diphosphate sugars to substrates such as polysaccharides and lipids. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. Indeed, the members of this family appear to never be found in a genome lacking squalene-hopene cyclase (SHC), although not all genomes encoding SHC have this glycosyl transferase. In the organism Zymomonas mobilis the linkage of this gene to hopanoid biosynthesis has been noted and the gene named HpnB. Hopanoids are known to feature polar glycosyl head groups in many organisms.	1.04991e-31
NC_012483.1|WP_015898100.1|3533667_3534810_+|hydrogenase-small-subunit	gnl|CDD|224654	COG1740, HyaA, Ni,Fe-hydrogenase I small subunit [Energy production and conversion].	7.30027e-146
NC_012483.1|WP_041839620.1|3530879_3531524_+|ferric-reductase-like-transmembrane-domain-containing-protein	gnl|CDD|235452	PRK05419, PRK05419, protein-methionine-sulfoxide reductase heme-binding subunit MsrQ.	4.42911e-66
NC_012483.1|WP_015898089.1|3525069_3525723_+|AhpC/TSA-family-protein	gnl|CDD|239268	cd02970, PRX_like2, Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these proteins do not contain the other two residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. TRXs alter the redox state of target proteins by catalyzing the reduction of their disulfide bonds via the CXXC motif using reducing equivalents derived from either NADPH or ferredoxins.	1.34009e-33

Protein sequences

>NC_012483.1|WP_015898092.1|3526995_3527547_+|alkyl-hydroperoxide-reductase-AhpD
MPIDTVMETLPGYAKDIKLNYSTLVRQNTELTPQQLWGTVVASAIATRNDTLTAAALEDGAQHLSEQALEAARIAAALMSMNNIFYRFQHLSSNEKYATMPARLRMNGMRTHGVEPVDFELWSLAVSAINGCGKCVDSHEKVLREKGAGEDLVLAAVRVASVIHAIGAVLDAEKVHQPEAAMA
>NC_012483.1|WP_015898091.1|3526376_3526913_+|peroxiredoxin
MLTVGEKFPSFSVTATVSTDKNKAFETITDESYAGKWKIYFFWPKDFTFVCPTEIAAFGKLNGEFQDRDAQVLGGSIDSEFVHLAWRNNHEDLKDLPFPMLADVKRDLCGQLGILDVNAGVAQRATFIVDPENIIRFVYVTDLSVGRNPQEVLRVLDALQTDELCPCNWQKGEETLTV
>NC_012483.1|WP_015898090.1|3525873_3526305_+|transcriptional-repressor
MLMHAAEQFRAICEEAGLAVTHQRLVIWEKLATMPGHPSPEEVYAQVKEEIPSISLATVYKTIHLFVDTGIFREASPHHGSMRVETNHEPHHHLVCRVCKSITDIPSEQLGFGGPLGDVPGGFLVERYAVDVLGICAGCRKPA
>NC_012483.1|WP_015898089.1|3525069_3525723_+|AhpC/TSA-family-protein
MAHLQDQLDLITENTRNLVQPERLAISDRAVEELFTTGIEQHILPVGAKAPEFELPDATGRTVRSQDLLALGPLVINFFRGRWCPYCVTELEAWRDLYPVVREQGGLVVAISPQTQRQSDFTAGHHKLPFPLLTDFECQLASQFGLMYSVPDYQRNYYRSILVNIPFVNGEESWRLPLPATYVVGQDGTVVFAEAYADFRVRPEPEEVLAPLLARQR
>NC_012483.1|WP_015898088.1|3523579_3524995_+|glycosyl-hydrolase-family-30
MPVTRREFVRHAAATAAVAASAPRLLAQSVNVASGALVDAGMEHQVMDGFGFSEAFHQARNLQDMPEPARTQLLDLLYDQKKGLGFSILRNIIGDGGAGQKSRNGSSGTIEPAPGEWNWKGDEDQLWLMGEAKKRGCGRFFSTAWSPPAWMKTTHQVNRGGQLAPDKYQAFADYLAEYVLGYKKHFGIDIYALSPANEPDFLAPWPSCIWSGEQMAVFLRTALIPTFQKKGVTAQIVVNEDARWMDLAINTILADPVCEKGVSIVAAHAYADDVTPYVPLAERTGVFHQALKDGKRVWQTEVSADGKNITNITDGIYWARLVHRHLVEDQVSGWLWWWGASLAGNYRGSLVGLDLKTGTYQLTKRLYTIGQYARFIRPGAHRIEATQTPATDVDFSAYRDEASGKTILVAINKGYAEQAFPVQLSGATATRCQAVRTSASENHAALPPVEVKNNRIVAVAAPESVTTWVLA
>NC_012483.1|WP_041839618.1|3522138_3523389_-|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase
MPQMQRRKTHTVKIGKVRVGSDAPVVVQSMTNTDTADVASTIQQVAALATAGSELVRVTVNNDEAAKAVPAIVEGLDKLGIDVPIVGDFHYNGHQLLKKYPECARALAKYRINPGNVSIGRKDDDNFRTMIECAVENQKPVRIGVNWGSLDQALLTRMMDENSKLSNPLPARDVMMEAMCRSALDSAAAAEQYGLRSDQIIISGKVSGVLDLIDVYQMLAARCEYPLHLGLTEAGMGMKGIVASTAGLAPLLLQGIGDTIRVSLTPKPGGDRTEEVLTAQQILQSLGIRSFTPQVTACPGCGRTTSTFFQELAQQIQDYLRESMPVWRAQYPGVEELKLAVMGCVVNGPGESKHANIGISLPGTFEEPKAPVYVDGRLLTTLRGDTIVSDFQKILDDYVKNRYGSSQSEAELVEVH
>NC_012483.1|WP_015898086.1|3521480_3522044_-|hypothetical-protein
MGLRRTSAISAAFSARTAGRMGGFLLAGVLACSGITAQAARRCYASAQALHHLHHKACIRAHVYREINLDDGTRILDLCGPDAADCEFALVSLDRNRKSVGSLKQFVGTDIEVLGTVEPIRGRAEILLRKAGQVRSRDAREVAAARPRERRVKQDRFRANPTLLKSFNAEQNRAPVSDPAFHGGYSY
>NC_012483.1|WP_015898085.1|3520274_3521465_+|glycosyltransferase
MKLFWLAVSIGNWMLALGWTWRVLTALYHLPRVPDLREDRYAAPPQQDRTPRLTVVVPARNEAAAVEGTLRSLLAQEMPLDIIAVDDRSEDATGSIMDRVAAEALPEGKTLRVIHVTELPEGWLGKNHALALAARQATTPWMLFTDGDIFFSPDALPRALHHAESVRADHFVLLPTPILLTNGERMMMSFIQVAAAAGGRLWRVSDPAAKSESIGVGAFNMVRREAYDGIGGFEAMRMEVLEDLRFGYLVKSSGYQQGVAFGPGMVRVHWAPGMVGILHNLTKNAFAVFRFQLPLILAACFGMMLAFLLPVVGWFGPLECRVASAMVAITIFLIYRFHRGFNDFRWWGFLTFPVAGSLFIYAVLRSTLLTLWRGGVVWRGTFYPLRELRQQLGRLR
>NC_012483.1|WP_148215313.1|3519051_3520278_+|MFS-transporter
MRGTGARSMGWLALALLTGLNLFNFIDRYVLPGAQPLIQKQFHANDAQMGLLTNAFFFVYMLAAPLTGWLGDRLPRKPLIVAGAVLWSVATLLTGVVHSYTALLIRHAIVGVGEATFSVFAPALLADYFPESARNRVYSLFYLTIPVGGAIGYILGGVLGQHYGWRAPFYVSAAPGLLIALLLWWLVEEAPRGQADRYAATWERNTLRGLFRNKLFWSATLGLATWTFAVGGLSAFLPTFFVRFGGDSVARAGLLAGAITVVAGIGGTALGGWLGQLWLRRNAGGLYLISAWGSLLAIPAGMLVFFGPRGLLFPAALVAELLLFLGTGPLNASIVNSVAAPVRSTAIALNLLTIHLLGDAFSPALIGLVSDHSSLRIGMSMTLFALVLSGGLLFLGGRLMNLAARAAA
>NC_012483.1|WP_015898083.1|3518599_3519004_+|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF
MSTGYTDDHAKAGLDFSFPAIDTWRNQFPAYEILIDDPEFTSVCPKTGLPDFGAITLRYMPRERCLELKSWKEYLFTYRNLGIFQENIVNQVLEDVVKACDPVWAVVRGEFRPRGGISTTVEARWPRPSTGQSR
>NC_012483.1|WP_169305988.1|3528080_3528248_-|hypothetical-protein
MTLQVIGALIIAGNVIGLILVIFWMGLGMPVHFADFRERFRQTFFRHPHKPAKHH
>NC_012483.1|WP_015898095.1|3528367_3528541_-|hypothetical-protein
MTAIEIIGVILATSHVLTVGLIVLWFGLNKPKTLTLFRQRFRAALFPARARSTHSLR
>NC_012483.1|WP_041839619.1|3528689_3529706_-|ketoacyl-ACP-synthase-III
MSLQVRPSASRRAKISSLGTYVPPRVLTNADLEKMVDTTDEWITTRVGIRERHILEKGKGTSDMAVEAARICLEKRGLAATDVEVIIVATVTPDMLFPATACLVQDKLGAKGAWGFDLSAACSGFVYALQMGCKLVESGAHSRVLVIGADTMSSILDYTDRTTCVLFGDGAGAVLIEPAEEGETGMIDFVHEIDGSGGCSLYMPAGGSLNPPTHETIDKRMHYVHQDGQAVYKFAVRKMTEATTRVLERNGITGADLGCFIPHQANRRIIDASAERLGLPAEKVVINIDRYGNTTAATIPLAMGTALEEGRLKKNDLILIASVGAGFTVGAALLRWEF
>NC_012483.1|WP_015898097.1|3529894_3530863_+|protein-methionine-sulfoxide-reductase-catalytic-subunit-MsrP
MPSKKYELPESEITPKSVFLNRRKFMMGAAVAGVGLAAAAGVDRLVSPGTRVLAGTKLPATPNPNYGKGLKPTSYQDVTHYNNFYEFGTSKSDPSENAWRLKTEPWTVEVEGLVHKKKTFDIDQLMKLRPLEDRVYRFRCVEAWSMVIPWVGYSLSELIKACDPLSTARYVQFISVDRPNQEPGIMSVNIPWPYSEGLRMDEAMHPLTLLTLGLYGEALPNQSGAPVRVIVPWKYGFKSAKSIVKIRFVKNQPPTTWNLIAPNEYGFYSNVNPNVDHTPWSQARERVIGAPIWKQLQPTQMFNGYADEVAGLYKGMNLNTYY
>NC_012483.1|WP_041839620.1|3530879_3531524_+|ferric-reductase-like-transmembrane-domain-containing-protein
MPKKLIIFLKVLVHLACLLPIAWLVYAGFENNLGPDPTHTVTFFTGRSTLRLLAITLAISPVRKLIPKLGWLIRFRRLVGLYAFFYACLHLLTYVWLYAGFSLAAMEQDISQRRFIVAGLAAWLLMVPLALTSTNWSIRKLGGKNWNRLHKLTYAAAIAGLVHYWWGVKPGVTTPMFLTLLIGGLLLARPVVKAIREGKNGDRKPPVAVGAEKM
>NC_012483.1|WP_015898100.1|3533667_3534810_+|hydrogenase-small-subunit
MDLPVHSADQGSVYEACQRRGISRRRFLQFCSAITATLALPSGYAKVVAAALTEKRKPTVVWLEYQDCAGCTESMLRSAHPTIEDIVLEAINLEYHETIMAGAGAAAESVLQKVVKNEKGKYLVIVEGAIPTADGGVYCTIGGRTALDLAREVCGNAAGVIAVGACAWDGGLVRSHPDPTGALGVQEALPELNVINLAGCPHNVANTTAVLVHYLTFGEMPALDQYNRPLFAYGQIVHDQCQRRAHYDAGRFVEAWGDEGHRQGWCLYKMGCKGPEATFNCPVVQWNSGTSWPVRAGHGCIACASPRFWDTASPFYERLPHPPGFGVDVTAGDIGWSIVGGVAALSAAHGVGRVVRDHLHPHKEETPPYEVRGCQEEDKQ
>NC_012483.1|WP_015898101.1|3534809_3536546_+|nickel-dependent-hydrogenase-large-subunit
MARIVVDPVTRIEGHLRIEAEMKGNAVGDAWSSGTMFRGIELILRGRDPREAWIWAQRICGVCTTVHALASVRAVEDALGVEIPDNARLVRNIIAGAQNVQDHIIHFYHLHALDWVDVTLALKADPAKTSQIAQSISEWPKSSTTYFKAVQDRVKTLVGSGQLSLFASGYWGHPAYRLPPEVNLLAVAHYIEALDLQREFIRIHAVLGGKNPHPQTFLVGGMATAMDGNEPDAVINPERITLLNQLVAQGKTFVDQVYLPDVMAIAGYYKDWFGYGEGLGNFMSYGDFTSRYQNDPAQFLVPRGIVLGRDLSTVHKVEPEKITESVAHSWYHYSGGDETVRNPYEGETNPAYTGPKPPYEYLNVDEKYSWLKAPRYDGKAVEVGPLARVLVAYAAGHQGTRKVVDATLQHFNAPPAVLFSTLGRIAARALEAQLLVNQLPGWVAQLDDNMAHGNVAIHNGEKWDPDSWPKSCRGFGFHEAPRGSLGHWIEIENKQIVNYQAVVPSTWNAGPRDASGQRGAYEAALAGTPIADPERPLEILRTVHSFDPCLACAVHVVGAQGRATTSPLGCAIPALQEV
>NC_012483.1|WP_015898102.1|3536549_3537344_+|Ni/Fe-hydrogenase,-b-type-cytochrome-subunit
MATRVDAVPVETPKPPVDDLVRVYVWQWPVRIVHWTIFFCITALSITGMYMHFPYLEAHSPNAWTMGTMRFIHEVFGFVLLAALILRIYWFFAGNRYSRWLSYLPLTKQQHKRLESTISYYGLIRRMPMPEVGHNPLAAVFYLGVYFAIAVECVTGLTLYATVSHDHFASFLTGWLSHSVSIQYVRFTHYFIMFLLIGFFVHHLYSALINAFDLKNGIMGSIFSGWKFMQRSVVEEEMCAEREARKAKRERREQRRARRTNGSA
>NC_012483.1|WP_015898103.1|3537330_3537843_+|hydrogenase-maturation-protease
MEARKRICVLGLGNLMRTDDAVGMMAVSALAEDPGSMDEVFCVEGSTLGLDLMHALHGVTHLLALDAVDVGTAPGEMVRFEKDELGDIPSGKSVHLLGFADLIGVLRLMGDEPEEIVLLGIQPKLIGWGTELTDEVHKTLPVLIEESRKQVENWLAVKQVPADERADVMV
>NC_012483.1|WP_015898104.1|3537847_3538195_+|hydrogenase-maturation-nickel-metallochaperone-HypA
MHEVGIANAILEAAQTEVARLAGTRLTRVGVRIGVLSGVDIDALEFALAALRKGTELEKIDVELQKCPRRNRCAKCGCEFETDLYSEPCPSCANEQVQLIGGEELELAFVEVDEA

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	MT708550	Achromobacter phage Mano, complete genome	15002-15036	8	0.771
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	MT778839	Rhizobium phage P9VFCI, complete genome	143732-143766	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NC_012586	Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence	2138660-2138694	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NC_019849	Sinorhizobium meliloti GR4 plasmid pRmeGR4d, complete sequence	197958-197992	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NZ_CP013110	Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence	590513-590547	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NC_017326	Sinorhizobium meliloti SM11 plasmid pSmeSM11d, complete sequence	197717-197751	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NC_017323	Sinorhizobium meliloti BL225C plasmid pSINMEB02, complete sequence	1433041-1433075	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NZ_CP024310	Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence	561771-561805	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NZ_CP021820	Sinorhizobium meliloti strain M162 plasmid psymB, complete sequence	536256-536290	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NZ_CP021831	Sinorhizobium meliloti strain HM006 plasmid psymB, complete sequence	442916-442950	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NZ_CP013054	Sinorhizobium americanum CCGM7 plasmid C, complete sequence	1783404-1783438	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NZ_CP021823	Sinorhizobium meliloti strain KH46 plasmid psymB, complete sequence	1233653-1233687	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NZ_CP021814	Sinorhizobium meliloti strain M270 plasmid psymB, complete sequence	71745-71779	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NZ_CP021795	Sinorhizobium meliloti strain USDA1157 plasmid psymB, complete sequence	772026-772060	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NZ_CP021806	Sinorhizobium meliloti strain T073 plasmid psymB, complete sequence	824013-824047	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NZ_CP023064	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence	382501-382535	9	0.743
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NC_009620	Sinorhizobium medicae WSM419 plasmid pSMED01, complete sequence	725995-726029	9	0.743
NC_012483_1	1.3|894333|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894333-894367	35	NZ_CP009112	Rhodococcus opacus strain 1CP plasmid pR1CP1, complete sequence	733200-733234	10	0.714
NC_012483_1	1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	894400-894434	35	NZ_CP029452	Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence	1722444-1722478	10	0.714
NC_012483_1	1.20|895458|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	895458-895492	35	NC_047962	Xanthomonas phage Carpasina, complete genome	60312-60346	10	0.714
NC_012483_1	1.20|895458|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	895458-895492	35	MH191395	Xanthomonas virus XcP1, complete genome	60224-60258	10	0.714
NC_012483_1	1.21|895525|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	895525-895559	35	NC_047962	Xanthomonas phage Carpasina, complete genome	60312-60346	10	0.714
NC_012483_1	1.21|895525|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	895525-895559	35	MH191395	Xanthomonas virus XcP1, complete genome	60224-60258	10	0.714
NC_012483_1	1.22|895592|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	895592-895626	35	NC_047962	Xanthomonas phage Carpasina, complete genome	60312-60346	10	0.714
NC_012483_1	1.22|895592|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT	895592-895626	35	MH191395	Xanthomonas virus XcP1, complete genome	60224-60258	10	0.714

1. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to MT708550 (Achromobacter phage Mano, complete genome) position: , mismatch: 8, identity: 0.771

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gccgcggtgtagccgctgccgcggttcgtgatggt	Protospacer
*.  *.**************** *** ***** * 

2. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to MT778839 (Rhizobium phage P9VFCI, complete genome) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
ttgtcagtgtagccggtaccgccgttgacaataag	Protospacer
 ************** *.*********...** ..

3. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NC_012586 (Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcccttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

4. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NC_019849 (Sinorhizobium meliloti GR4 plasmid pRmeGR4d, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcctttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

5. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013110 (Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcccttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

6. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NC_017326 (Sinorhizobium meliloti SM11 plasmid pSmeSM11d, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcctttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

7. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NC_017323 (Sinorhizobium meliloti BL225C plasmid pSINMEB02, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcctttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

8. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024310 (Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcccttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

9. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021820 (Sinorhizobium meliloti strain M162 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcctttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

10. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021831 (Sinorhizobium meliloti strain HM006 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcctttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

11. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013054 (Sinorhizobium americanum CCGM7 plasmid C, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcccttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

12. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021823 (Sinorhizobium meliloti strain KH46 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcctttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

13. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021814 (Sinorhizobium meliloti strain M270 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcctttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

14. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021795 (Sinorhizobium meliloti strain USDA1157 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcctttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

15. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021806 (Sinorhizobium meliloti strain T073 plasmid psymB, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcctttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

16. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023064 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcccttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

17. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NC_009620 (Sinorhizobium medicae WSM419 plasmid pSMED01, complete sequence) position: , mismatch: 9, identity: 0.743

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcggcgcggtagccgccgccgcccttggtgatctg	Protospacer
*.* *.  ********.****** ********* .

18. spacer 1.3|894333|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009112 (Rhodococcus opacus strain 1CP plasmid pR1CP1, complete sequence) position: , mismatch: 10, identity: 0.714

cgtgccactgagatcgagagagccttccacgctca	CRISPR spacer
attcccactgagatcgagcgggccttccatgacgc	Protospacer
  * ************** *.********.* .  

19. spacer 1.4|894400|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029452 (Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence) position: , mismatch: 10, identity: 0.714

gtgtcagtgtagccgctgccgccgttggtgatcga	CRISPR spacer
gcagcgcggtagccgccgccgcccttggtgatctg	Protospacer
*.. *.  ********.****** ********* .

20. spacer 1.20|895458|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NC_047962 (Xanthomonas phage Carpasina, complete genome) position: , mismatch: 10, identity: 0.714

gtgtgttgatcggctggctgccttccccggcggtt	CRISPR spacer
ctgagttggtcggctggctgccttccgatgaatct	Protospacer
 ** ****.*****************   * . .*

21. spacer 1.20|895458|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to MH191395 (Xanthomonas virus XcP1, complete genome) position: , mismatch: 10, identity: 0.714

gtgtgttgatcggctggctgccttccccggcggtt	CRISPR spacer
ctgagttggtcggctggctgccttccgatgaatct	Protospacer
 ** ****.*****************   * . .*

22. spacer 1.21|895525|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NC_047962 (Xanthomonas phage Carpasina, complete genome) position: , mismatch: 10, identity: 0.714

gtgtgttgatcggctggctgccttccccggcggtt	CRISPR spacer
ctgagttggtcggctggctgccttccgatgaatct	Protospacer
 ** ****.*****************   * . .*

23. spacer 1.21|895525|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to MH191395 (Xanthomonas virus XcP1, complete genome) position: , mismatch: 10, identity: 0.714

gtgtgttgatcggctggctgccttccccggcggtt	CRISPR spacer
ctgagttggtcggctggctgccttccgatgaatct	Protospacer
 ** ****.*****************   * . .*

24. spacer 1.22|895592|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to NC_047962 (Xanthomonas phage Carpasina, complete genome) position: , mismatch: 10, identity: 0.714

gtgtgttgatcggctggctgccttccccggcggtt	CRISPR spacer
ctgagttggtcggctggctgccttccgatgaatct	Protospacer
 ** ****.*****************   * . .*

25. spacer 1.22|895592|35|NC_012483|PILER-CR,CRISPRCasFinder,CRT matches to MH191395 (Xanthomonas virus XcP1, complete genome) position: , mismatch: 10, identity: 0.714

gtgtgttgatcggctggctgccttccccggcggtt	CRISPR spacer
ctgagttggtcggctggctgccttccgatgaatct	Protospacer
 ** ****.*****************   * . .*

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	3000618 : 3073984	60	Acinetobacter_phage(10.0%)	protease,transposase	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_012483|3000618:3073984|DBSCAN-SWA
CTCACACCCGCAGCAGAATCATGTTCACCATCGCCAGCAGCGGACTCAGGAAAAAGTCCATCACCGGCGCGCCCACAAAAATGATCAGCGCCAGCCCAATCCAGCCGCCCAGCGAGTCGTAAAACTTCAGCGCGTTATAGGGCAGCAGGTTCCGCAGTATGTGCGAGCCATCCAGCGGCGGAATCGGCAGCAGATTAAAGATCGTCAGCATCAGGTTCAGCCACACGCTCAGGTACAACAGCAGCCCCACTGGAACCACCGCTCCGCCCTGCGTCAGCGCCAGTCCCCACGCGCCCGCCGCCAGCGCATGCACCACCAGCTCGCCCCCCGGAGCAGCCTTGGCCAGCACCACCAGCAGCACCACGCTCACCAGCGCAATCACCAGGTTGCTGCCCGGCCCGGCCAGCGTTACCAGCATGTCGTCGCGCTTGTAGTGCTTGAAGTTGCGCCCATTCACCGGCGTCGGCTTCGCCCAGCCAATCAGAAACTGCCCAAATCCCGGCGCAAACAGCATCACCAGCGGCAAAATAATCGTGCCCAGTATGTCGATGTGCTTCACCGGATTCAGCGTCACGCGTCCCAGCATGCGCGCCGTCTGGTCGCCCAGGCGCGAAGCCATCCACGCGTGCGAGGCTTCGTGCAGACTCAAGGCAAACAGAAGCAGTACAAATTCAAAGATTTTGATAACAATTTGCTGGTTCATGGACAGTCTGATCCTATCAGGCCATCCCCGCCGCCCGAACCCGTCCGCCCTACACCCACACGTCGTTGGCTGCCGTCAGCGCGCCGCCCGCATCACCCGTGTTCACCACCCCGCGCGGCTCCAGAATCAGCGCATGACACTCCCCGGCCGCCCGCGTAATGTGCTCCACCCCGCGCGGAACCACAAACATCTCTCCGGCCCCGAGCGTCACCGTGCGATCCCGAAAGCCAATCTCCATCTCGCCTTCGATCACCAGAAACGCCTCGTCCGTGTCCTCGTGCTGGTGCCACACAAACTCGCCCTTGAGCTTCACTACCTTGAACTGGTAGTCATTCATCTCGGCCACCACGCGCGGCGACCAGTGCTCTTCAAACTTCCCGAGCTTCTCCCTCAGGTTCACCACCTGCGGCTCACTCACACCCAGCTCCTCTCCGTCCCGGACGGTCCCGGCGGCGTCACCACCGCACCCCGTCCCACCATCATGCCCTTCGGAATCCTCAGCGCCGTCCGGTCCTCGAGCACCGCATACGGGCGAATCACGCACTCGTCCTCGAGCGCGACTTGATAGCCAAACGTGAACTCCACGCCGTGATAAATCTTCACGCCGCTGCCCATTTCCGCAAAAATGTGCCGCCCCAGCATCCGCCGGAAGCGAAATCCCAGGCAATGGTTCAGCGCCAGCGGCGTCCGGTCAAACATCTGCCAGAACCACACCAGCGGCTTCACCGGCGCAAACCGCTCGCGGTCCAGCTCCGGCTCATACTCGGCCGCCAGCGTCACATTGTTCGGGTCCAGCGCCAGCTCCATCACGTTGTAGGGCAGCTCGCTCACCAGCGTAAAGTTCAGCCGCCCGGCCGGCGCGCGCCCCAGCAGAATATGGTGCAGATTATCCCGCACCAGCTCGGCCCGAATCGACGGCTTCTTGTGCCGGGTAAACTCATCGTCCAAAAACGCAATCCAGCGATCAAAGACCTCATCGGCCTCCCGCGTCGGCCGCGGCTCAGCAACTTCAGGATTCGTCATAACCATCCTTCGCCAACGAGTGTACGCCGCCCGCATCTCCTCCGAAAAAGGCGGGTGCCCCACGTCTCGATTTTGAGACGTGGGAGCCTTGTCCTGCTCAGTCCGCCCGTGGGGACCCCGGGTGCCCCATGCAAGCCTGCCGTTGCCTTGAGTGCGGTTGTTTCTTTTGCCTCATAGAACGCCCGTATCAGGGCACGGCTTCAGCCGTGCCGTCAGGCAGCAAAATTAAAGACGGGCTTCAGCCCCTGCATCCCACCCCGCCTTGTCATTCCCGATCGAACGAAGTGAGCGGAGGGACCTGCATGATTTTTCGCCCGCCAATCCAGCAGTGCCCACCCGGCGAGCAACGCGAGCGCCGAGGGACCCGGCACCCAAAAGGCGCCGAAGGCGCGCCCGCCTGGACGGCCAGTCCTACTGAATCGCAAACACCGCATACACCGTCGCCGAATCCGTGATCCGCTCCGGCTCAATGCTCAGCGGTTTCACCGCCTCTTGCGGAGCGGCCGACTTCGCCATCATCATCGCGTGAAAAATCGGCGTCGGTGTGAGCGTGGGTCCGCGATTGCTCGCATACAGCAGCGGACCCAGCGTCACGCCCAGCCCCTCGGCCATCGTGGCCGCCATGCGCTTGTCGTTGGCCAGTGCCTTGGCTGCGGCCTTGGCCAGCAACGCCTCGTCATCGGCCACTGACCACTGAATATTCCCGCTATTGTTCGCCCCCGCCGTCACGGCCGCATGCAGCACGCGCGCCACCTCGCCCGCCTTCAGCCGCACCGCCCACGTCTGCTCCGCGTGGTATTTGCGCGCCTCGCGCTCGGCCGGAGTCAGGTTCTGGTTCTCATACGCCTGTGTCTCCATAACCGACTCGCTCTGGCTCTCGATCTGGTCCTTCGCCACGCCGGCCTTGGCCAGCGCATCGGCAATCGCATTTGAGGTCTTCGAGGCCTCGGCATAAGCCGCCTCTGACGTGGGTCCATACACGCTGTAGCCAACGCTCAGCACCGCGCGATCCGCCGTCGCGGTTGCCGTCCCGTTACTGGTCACCGCCAGCGTGCGATTCGCCTTGCTCACCTGAATCGTCTGCGCCCCTGCAGCCACCGCACCCGTCAGTAGCAGCGCCATTCCCCAACGAACCGTTTGCGAAACTCGCAAAGCCATACCGTCTCTCCTTACCTCGATTGGAACTGTGGGTTCTGCCAGTTTGAGATGCGGCAAAGGCGTGCCTGGGTTTGGCCTGACTTATCATCCCGAACTCCGCCCCACCCACAATGCGTCATTCTGAGCGAATCGGGGTGGTGAAGCGAAGAATCCCGGCGATGCTCCGGTCGCTAAATGCCGTCCGGAGTTTCTCCCAATATCCCCGCCACTCCTCTCCCAGCGTCCACAGCGAGAACGCCCCACAACTGCCAACTGCCAACTGAGGACTGACAACTGACAACTGACAACTACCCGATCGTCTTCCCAAAGGCCCGCAGCTTCTCCACCGTCTGCCGCGCCGCGCCCGACTCAATCGCAATCGCGCACCGCGCCACGCCTTCTCTGAAGCTTGTCGCAACTCCGCTCACCACCAGCGCCGCCGCGGCATTCAGCAGCACAATGTCGGTGCGCGGTCCCGTCTCGCCCTCTAAAATCTTCTCGATCAATGCCGCATTCGCCGCCACCGTTGCCGCGCCCTGCAGTTGATCGAGCGTGCAAAAAGGCAGGTCCGCCTCTGACGGATAAAACTCATGCCGCCGCAGCAGCCCGTCGCGCACCTCCACCATGTGCGACATGCCCGTCAGCGTCAGTTCATCGAGTCCGTCGCTGCCATGCACCACCATCGCGTGCCGCACGCCCAGCCTGGACAGCGCCTCGGCGGCCACCACCACCTTGTTCGCCGCATACACGCCCATCACCTGCGCCCGCGCTCCGGCAGGATTCGTCAGCGGCCCGGCCATATTGAAAATCGTGCGAAAGCCCAGCGCCCGCCGGATCGGCTGCACCCGCTTCAGCGCCGGATGCAGCGCCGGCGCATACAGAAACGCAAATCCCGTCGCCCGCAGGCACTCCACCGACTGCTCCGGCGTCAGCGCCACCGGAATCCCCATCGCCTCCAGCACATCCGCCGACCCGCACTTCGACGTCACCGCGCGATTGCCGTGCTTGGCCACCTTCGCGCCCGCCGCCGCCGCCACCAGCGCCGCGCCCGTCGAAATGTTGAACGTGCCATCCCCCGAGCCGCCCGTCCCGCAGGTGTCCACCAGCGCCGCGCGCTCCTCGTCGGTAAAGGGCAGCGGAACGGCATGCGCCCGCATCTCCTCGGCAAAGCCGGCCAGCTCCTCGGCCGTCTCGCCGCGCTGCGAAATCGCGGTCAGCATGCGCGAAATGTCATCCGTGCTCGCCTCGCCCATGATCATCTCTCGCAGCGCTACACGGGCTTCCTCACGGGTCAGCGTCCCGATGTCTTCAACAACCTTCTGCACTAGCCGGGCAAACGGGCGGGGAGAGTCTTTCATGGCTGCAGACATGCTACTGCAACCCCCAGCGCATCCGCTCTGTAATTTGCGCCAACCCTCCCGGTGCCCCATTCAAGCGGCGTTGGCTTGAGTGGGGTTGCTTCTTTTGCCTCGCATGACACCTGTATCAGGGCACGGCTTCAGCCGTGCCGGTAAGCAGCCAATAGGGACTGGCTTCAGCCCCTGCATCCCACCCTACCCCTGTCATCCCGGCCAAGTGAATGTGATTTTGTATCTCATTGCAAGAATGGGAGATAAATAAGGTATTTTGCGCTGTGCAGGAATTGTGCAGGCATTTGTGCCCGCCTCTTCAAGTTGATAGTGCAACAAGGTGAGAAAAAGCTCAAAGAATTGGGGTAAATGCACCTCCAGTGGCTTAAGCCACTGGAGGTGCATTTTGGCGACATACCGACACCTGGGTCTCGATGACCGGGTACAAATTCAAGTCCTCACGAAACGAGGCATCTCGGATGCGGAGATTGCTCGGGAGTTGCAGGTTCATCGTTCTACCGTCGGTTGGGAGCGGCGACGAAACAAAGTGGGCAGCAAGTATTACCATCATCAGGCGCAGGCCTGCGCGGATCGACGTCAACGAGAACGGCGTCAGCGTCCGTCGAAGCTGACGCCTGCGGTGGTCGCCTTCGTTGAAGAAAAGTCGTGTGTCGGAGATTGGGAAGAGCAGCAAGTTGCTTCTCTCCGATACCTATCGATGTAAGCAGCCCGCAGAGGACTTGAACCATAATCCGCTTTATTCAATGACTTATAGCGCGCCAGCAAGACAGCTGAGTTAAGAAGGCATTATTGGGGGCGTTAGGCAAGATTTCTTCGCGCGCGGGAAGATGCTGTGTTTGTAACGGCAATACGTGACAAGAGAAACTTTCTCCTCAATGGTGAGAGAGCAGGGCTAATGTCGAGTCGTAGCTTCGCGAAGGTCAGAGTTGCGGGTTTGAATATACGGTTATTCTTCAGAGCATGTGTTGTTGCGGGATATCTGCTATGCATTATGTATGTCGGCATAGCCGCAGGCGAGGTCCAGAGCCGGATTACTGGCACCGTCAATTCGAACCAGGCCGTATCGCTGCAGGGAAGTGCGTTCCCATCTGCACGCCCGCAGAATCGCGTCGGCCCGATGAGTGTAGACACGCAACTCACCGGCATCACTATAGACTTCAAGCCCACAATAGCTCAGAAGGCAGAGCTCGACGCGCTACTGAAGGCGCAACAGACGCCTGGTTCGTCGTGGTATCACAAATGGCTTTCGCCCGCGGAGTATGCAAGCGAATTCGGTCTGAGCGACAACGATCTTTCGAAGATCGAACGTTGGTTGCAAGATCAGGGATTCACAATCGACCGCGTCGCAAATAATCATAGCTACATCACCTTTTCCGGCACCGTTTCCCAGGTCAATTCAGCGTTTGCGACGGAGATGGATTACTACAAGATTGCAGATAAGACCCACTTTGCCAATGCAACCAATCTCTCCATCCCTTCCGCTCTTTCCGGTGTTGTGGAATCCGTGCGCAATCTTAACGACTTTCGGCCAAGACCGCATGTGCGTTTTCATCTTTCACACACGGGCGCTGTGCGGCCCGGCTTTACGTCTTCTGAGTCGGGTAGTCATTATCTGCAACCCGGAGATGTTGCTACGATCTATGACATTACGCCCGCATATGATGCCGGTTATACGGGTTCTGGCCAGTCCATCGCGGTCGTTGGCCAGTCGGAGATCGATGTCTCCGACATCGAGCATTTTCAGAGCGCGGCCGGGCTCACCGAAAAAGCACCTACCCTGGTTCTGGTTCCGGGTTCGGGAACGGCGGCATTTTCTTCCGACGATGAGGCGGAGTCTGATCTCGATCTGGAATACGCTGGGGGCATTGCCAAGGGAGCGGCTATTTACTTCGTTTACGTAGGAAATAACCAGAATTACAGCGTCTTTGACGCCCTGCAGTATGCCGTAGATACAAAGATTGCTCCCATCATCAGCATGAGCTATGGTGCCTGCGAGATGGAGCTGAGCTCCGATGATTACTCCAGCCTCGAGTCCATTATGGAGGAAGCCGCAAGTCAGGGGCAAAGTGTGATTGTCGCGACAGGCGATGACGGCTCGACAGATTGCTATGGAGAAAGTGGGCTGAGTGAGACGAAACAGGAAGATCTCGCCGTCGACTATCCAGCCAGCAGCGCGTATGTGACCGGGGTGGGCGGCACGGAGTTTCCCGCAGCTGATATCGCTTCTTCAAACACCACCTACTGGGAATCTGCGTCGGGAAGCGACGTCATTACATCCGCGAAGTCATACATCCCCGAGGTAGCCTGGAATGACGATTCAACCTGTGCGGAATATGTTAGCGACGGCAGCTCTCCACTCTGCTCCGGCGGGGGTGGAGTAAGTACATTAACAGCTCGTCCAAGTTGGCAATCAGGTGTAACGGGGATTCCTTCAGGCGGTTATCGCCTAGTGCCGGATCTGTCGTTGAATGCGTCTCCGGTGAATGGGGGCTATCTCTATTGCACCAGCGACACCTCGGCCTGGAGCGAAGGACAACAGGCAAGTTGCAGCGACGGCTTTCGCGATTCTGCCACGCAGGACCTGACCGTTGCCGGTGGCACGAGTTTTGACGCGCCGATTTTTGCAGGCATGCTGGCAATTCTCAACCAGAAAGAGAACTCTACCGGTCAAGGGCTCATCAATTCAACGCTCTACCAACTTGCCTCGGATTCAAGCGCTTATGCCTCCGTGTTCCATGACATCACGAGCGGCGGTAATCAGTGCACGGCCGGATCCCAGTACTGCTCATCGACTGGCAAGTCTGAATATACGACCACAACTGGGTATGACGAGGCAACCGGTCTCGGGTCGGTGGACTTTTATAATCTACTCACTTCTTGGACGTCTGGCTCTTCTGCATCGCTGGAGGCCACCACGACGTCCCTCTCAGCTGCTACCGCAACTCCCTCTGCCGGTGCAAGCGACACGATTACTATCACCGTCGCCCCACAGTCGAGTTCGATCAGCAGCACACCGACCGGTACCGTGGCCGTCGTCGTAGACGGAACCACGGAAACGTCTTCGCTGGCGCTGACTAATGGCTCGGCCACATACACGTTTAGCTCAACAACGTCTGGGTCACATGTGATTGAGGCAACCTATTCGGGCGACTCGATTTTTGCTGGGTCCTCTGGTTCCATCACTGTCGATGTAGGCGGCGTGAATGGAAGCACATCCCCGGGAACTTTTACCGTATCGGCGTCGAATCTGACCGTATCGCAAGGAAGTTCGGGCACATCGACCATCACGGTCACTTCACAAAATTCCTATTCGGGCACCGCGAGCTTCTCACTGTCGACAACCAGCGCTTCTTTGTTGGAGTACGGCTGTTATTCCATTCCTAACGTGACCGTCTCTGCGGATCAGACAGCGACCACAACACTGACCATCTATACCTCGGAGAATGACTGTAGTTCCAGCTCGATTCGAAAAATGCAGCGCCGGTCATTCCTCCGCGCATCGACTGTGTCGGCAACCACCTCGCAGCCAAACAAACCCGGCCGCGGCCCATTTCCGGTTGCCTTTGCATGTATCGCTGGGGGAGTCCTATTTGTCCGTAAGCGCCGATTGAGAGCATTGCTATCGTGTTTACTCGTGGTTGGTGCCCTGTCATTGCCCATTGCGTGCGGCTCCCGGTCTGCCTCTTCCTCAAGTAGCTCCAGTTCCACGGCTGATGAAGTAGCCAAAGGGACATACACCATCACGCTCGATGGTGTGGACATCGCTGATTCCAGCATCGCATCTTCTACAACTTTCGCTCTCACTGTGGACTGAAGGCATCGGCAACACGAAGATCGGAGGTGCTCAAGCTGGGGAGCACTCTCTGATGACGGGGGCGCGCCGGCAAACGTGGGATGCTGGCGCCTTTCCGGAGAGAACGGGGAGCGACCCCTTGCCGCTCCCCGTTCATAATATTCTAATCCGGGCAAATAAGTGGAGCTAGAGCTACTCCAATGGAATAACAGGTCCTGAGATACCTGGGTGTCCGAGACGAATGATATGGGGCGTCACGAGAATGACCAGTTCTTGGTCACTGCTGCTGGTATCACGATTTGTCATATCGTGCAGGTCGGGGATCTCACTTAATCCGGGCATCCCAGTGAGATCAAGATTGTTCTGTTTAGACATCGAACTGACGATGAGCGCACTGTAGCCCGCGTGGATAGACACCTCTCCGCTGTACTGACGGTTGGTCAGCACTGGTATATCGTCGAGCGTAGTTCCTGCGAGTCCAGATAGTTGCAACTTCATGTGTAGCGTGACGTTCTTATTGGCTTGAATCGAAGGTGTGACCTTGAGTGTCAATCCAAGATTGACGTATTGAAATTGCGGACTTGTGCCTGTGGACTCTCCCAGGTTCCCGAGATTTGAAAGCTTTCCGGTCATGATCGGGTAACGCTCGCCATCCAGAAATGTTGCCTCTTTCTGGTCTCGTACACTGAGTTGTACCTGGTCGAGCGATATGACATTAGAAGAGGTGAGCAACATGTTTGCGGCGGTCGTATTCCACTCCGCTCCTGTCTCAGTAATTCCTCCGCCGAAGATTACAAATGGATTGTTGAAGTCGGTTCCAGAAATATCTCCCGCCGCAAGTAGAATTCCAATGATCGTCTCCCAGTCGCCGGCTTTAGCGAGACCGCTGGAAATGATCTCTTGTACAAGACTTGCATTCTCAGCCAGCACGCTGTCTGCCTCGGAATTCAAATTGAACAGTGTGACCGAGTTCGGAAGAATCGCACCTGTGTCATTCTCACCCGTGCGATCTACCTCGTAGACATGAATGTCCAACCTGACTTCGCTTGTGTCATCCAGCAGTTCGCGGTAAAGATGATTCAAAGCCATTAGAGTTGCGCCAGGCGCGCGCAGCGTAATGACCTTCTGATCCGGACTCAGCACAGCGCGAGTCACGCCGCCTGAATTGCGGGCAATATTTTCCATCTCCTCCAGTTCGTTTCTATCCATGCCGGGGAAGGTAATGGTTTCCATGATCTGGGGGTCGTATTGCCTCAGATTTTTCGTTGTATTCGCAACCACCAGAGCGCGGCGCACGCCCAAAGGTACAATTAAAACTCCGGTTGCCAGCCGAAGCGCCTTCTCCGCGCTCTTGAAATCTAGAGAATCCACGTCAAAGAACACGGACTGATCGTCGATATCAGGACCGATCTCTGCCTGGATACCGTAGGCTTGCAGGACCTGACGTATCACCGAAGGCTTCGTTGCGTGCAGATGAAAACTACAGTCTGCCTTCAATGCCACAAGTTTAATGGGCGCATTCGCACGCGAGGAATGCTGTCTTACGATAACGGGACTGCTTTCTGCTTTTGTCTTTTTTTTGTGAGGATGCAGTGTTGCCATTGCACTATACGGATGAGGCAGGGAAGCGTAATGCAAAGCATCCAGAATTTGACCGCTATGGGCGGCAGTTCCGGGCTCCCTTGCGAATGGAGTCGCAGAAAACCTCAGTGCCATACGCGCCGCAAGTGAATAGCGAGGGTTCGACCTATCCAGTTTTTCAGCAAGAAGAAACTCTTTCTCCGCAACTTTCATCCGATGCCGTTGAAAAGCACGCACCCCCTCCAGGTAGTGTTTCTCTGCTCTCATTTGATTTTGTCTTGATGTATGACGTGCCCCGGTCTGGTGCGTCTCATCTAGAGAAGCGATCTTTTGGTTCGCCATGAAGGCAGGGCCTGGTTCAACAAGTGGCTTTCCTACCCAGGCCGCTGCATTGCAGGTTGGCATCGTCAGGGCCGCTATGAGAACGGCTGACGCTCGCGCTCTAAGCATCATTCAGCACCTGTCAACTATGGATGTGACGCCGCTTGAGAAGAAGCCGCTTTGGGCTTCGCCGCCAAACTACTGTTCAGTTGGCCCGGAGGCTCGCGGAGTTGAATCATGTCTGCCGTTCCCGTATCTATCTCGCGCATGGTCAGTGGGTCGACTTGTGGCGAGCGAATGATATGAGGAGTAATCATAAAAACTAGCTCGTCGCTGGTGACCTCGTGCTTCTGGGTTGTGAAGAGATATTTCATGAAGGGAATCTCTCCAAAGCCTGGCCAGCCGCTCACGGTCTGGCTCACTTCTTTCTTGAGCAGACCAGCAAGGATAGTCGATTCGCCATTTTTTAGCCGAACAATCTGCTGCGCTTTCTCCTGGCTGATGATTGGCTCCTCAACACCCTCCAGATCTTCAGTGCCGTTCTCTGAAGAGACATCCACGCCAAGCTTTAACGTCACAGTGTGATCGAGATGAATCTGGGGCGTCATGTCAATATTGACGCCCACATCAAGATATTGAAATTGGGTTTCTGCTGCAGCGCTTGTCGAGCCCGTGGCATAGGTATAGGAACCAGTAGCCACAGGCAGCCGTTCCCCGAGCTTAAGACTGGCTTGTTCTCCGTTGAGAGCACGCAGTCGCGGGTTTTGCAGGATTTGTGTATTTGAGTCTGTTAACAGAAAGTCGGCTGCTGCCTGGCCGATGGTGATGCTATAGGCGGAGGTGTGTCCAATCTGTTCCAACGTCTGCGACGACCCGGAGTTTACAGTCAGCGACGTGGGAGGAGAAAGACCAATTTCCCGCATCTTGTCGCGGCTGACTTCCATTACTGTAACATCGACAAGGACTTCCGGTTTAGGTTCATCCAGACTTGCGATGAGCATCTTCGCCAGGCGCAGCTCATCTGGCGTGCCGAGCATCACGATTGTGTCGTTGCTCTCTATTCCGAAAATCCTTGCGGACTGAAATACATTTCTTAACGCTGTTTGAATACCGGTGAAGTCGCTCGCCTGCGACACGTTGCCAACGTAAAAAACTTCAAGGGCCTGATTGCTGTATTCTTTCCGCTTAGCCGGAGTATTTTGAGCGACAAAGATCGTGTTGTGCGTAACAGGCTGCCAGAAGGTTCCAGATACCTTGCCCACAATGTTCAGAGCCTGGTAGGGAGTGACATTGCTGAGATCCACCTGAATCCTGTTTGAGCTAGAGGATGGATCGAACAGCACGTTGATGCCAAGCAGCTTTCCGATAGTGAGATAAATAACTTTACTGTCCGCAAGCATGTGAAGCGTTACGGGTCCGGCAACAGGAATATCGAGGTCGACGGGAGACTCAGGCATATTTTCTGCCGAACCAGATGGAGCAGTCGATGCCTGGGTATGGGTGTTCTGCTGCAACCTCAGTTCCAGCGCGCGCGCGTCCGACTCAGCCATCTCATTAGTTGGATCGGCGTCGAGTGCTTTTAGATAAGCAGCCAGAGCTGGAGCGAGGTTGCCATGTGTAGCAAACCCCTGCCCTTCCTTAACGTATTCCTCTGCGGCAGCCGTGCGCACGCGCTCAAAGGCGATACGATAGCGAATCTCTCCTGGCTTTAATTCGGATGCGCTCTTATAAGCGCGATATGCGGCGATAGCATCATTTCGGGCTTCTGCAGCCTGCCCAATTTTATAATCACGCTTCGCGGATTCTGCGAGGGCTGGCGTGAGCAGCATCAGCAGGGGCACGGCGGCGAGAAGGACTCGAATATAAACTGTTACAAATGCATGTCGCGAATACGGCACAGAATAACTCCTGCCGGTATTGACTCGAAGCACTTCCCGGCTTCCCGGGATTTTGTAAATAAATGCGGTAATTAAATATTTCTTCGCTTGGGGTGGCGGGGAATTATCAGAGATGCGCACTGAGTGGCTCAGGCTATTTACATGTGATTTTTGCTTCCCGACATGATAGACGGTTGGCATTGCCGCAGCGCTCAAGGAAATGTGCGCTTATTCAGGCATAGATGCAAAACGATCCTGAATCATTATCCACGGCATAACCGTCTGCCGCGTTGCGAGGTGTTATATGAGCAGGACAACGCGTGGGTTCTACGCTAGTCGCAAGACCACGACCTAGAAGTCGGTCGGATCGAAAGGCCGCGGTGGCGTGTCGAGTCTTTGAAGGGTGTAGCCGGCAGGAATGCGAAACAGGCTCTCCTTTGGATTCTCCAGCCTGAGCCCTTTGATCATATAGGTCGTATTGCCGAACCGCGCATCTCTACGCATGCTTAACAATACAAGTTGAAGCTTTGGCGAATACCATGTATCTTCTGTTGTTACTATTGGACGATCGTTACCAATAGCGCTGACCGGAATGGTCCAGGTTCGCCGTGTTCCTATCGCTTTTACGCCGTCCACTGTTCTGGAGCCCAATGTTTTTGTTTCCGTGTCGCATCCGTCGCAGCCGCCGGCGAACTCTAGCCGGAAGGACGGTCCTCCCATGTCCGCTGCCCCAGGTATGTGATGAACGGAAAGCTGTTGGGTAGCTCTCGAAGCTGCTCCGGGAGACGCGTTTCGGAAGATTGGCTTGCCGGGAAGAACGCCTATCGGAGAGACATGGGCAACTTTCACATCTGAGGTGAAAACAATATGTTCGTGTGAGACTGGATCGAAGATAGAGGTAAGAATCGGCGGTTGTGCGTGAACGTCTGCGGTGGAACCGTTGCCCCCTGCTCGAAAAACGAAGAATGCTCCATTCCACCCCAGTCTCTCGACACGAACCGTTCTTCCTTGCTTATCGCGCGCAACCGTTGCAGTAATTGTCTGTCGGATGTGCGTGCCGTCTGCCAGCGTTTGCCTGATTTCTGTGATGGCCTCGGCCTGATAGGGCTCGTTTCTTACGACTGCCGTTCGTTCTGGCCCCTCAAAGGGTCCGCCCAGTCCAGGAGGTGGTCCAACCTGCATACCCGCAATCAACTGTCCATTGATCTCATGACCATTTATAAGATCGGCGTGAACAGCTCCCGCAGCATAGACTCCATAGCAAGTTACAAGAGTCAGACAGCAGCAGAGCTTCCAGTTCATTCCATGTCTCCTGTTGTAGTGAGCGGGAAAGGCACGCTGAGGGCGCGCGGCAGACCGTCAGCGCCCAGGATTAATTCTGCGACAAATCGGTGATGACCCTCCTCGGAACTGACAGGGACTCCCAAGGTAAGCAGCTCATTCTGCGAGACAGACACAGGAATCGTTGAGATGGTTCCTGTCGTCACCGCGCGGTCAGAGTACGGCAGCGGAATGATAAGATTACCTGCTTCGTTTGCAACCGCTGCAGAGATGACAGTCTCGGTATGAACTGCTTCCGGCGCTGTCGATGACGAGATCTTCGCCGCAGAGGCAGCGGGATGGGTGGGCACAGGCTGTGCAGAATTAGAGGCGATTCTGGCGATACCGGACGCATCCCTTTGCGGCAAAAGAAGCCTTGTTATCAGCCAAGGCAAAAGGACACAGGCCACTGTGGCAGCTGCAGAGAGAGCAAGAATGCGGACCCGCACTGCGCGCTGTCTCGAATCTAAGGCGCCTGGCTTCTGCGCATTAGAGTGCTGTTTGCTGATTATCCTGAGGTATTCGCGCAAAGCTGGAGGAGGTTCGTGCTGAGTCTGATGCCGTAGTTCCTCCAGCATCGAATCCAGGGAAGAAAACTGTGCGTTCTCTATCTTCGACGAGGACGGTTTCATTTGCGTACCCTCCTTATTCATATTATTGAGCCTTGGATGAAGCGGATTTCTCATCGGAGGGCTGACGCATCTTTGCTGCCAGCAGCCCCTTCGCACGATTCATGCGGGAGGCGATGGTGCCTTCTGTGACCTGCAGAAGCGTCGCCGCATCCTTATAGCTCTTCTCCTGCAGGCTGCACAATACGAGAACCTCTCTGTAGTGCGTCGGAAGTTCTAAGATGGCGCGATACAAGCTCCGCAATTCTGCCCGGGCCACAACTACGGCCAAGCTTTCATCGGATATTCTGCCATTGCCGGTGAGGAGTTCATTGGTCTCATTTCCTATAGAAAGGTCTAACATACCCTCCAGAGAGACGAGTCGTCTCCCTTTGCGCAGCTCTCTCCTCGCGAGGTTTCTTGCAATTCCCAGCAGGTAGCCTTCGAGTGTTCCTTTTTCCGGATCGAAACCCAGTTGTTTTTCGCCAGACATTATTTCCAGGATCACCACAAACGCTTCCTGGGTCAGATCTTCCGCAATCGTGAGAGACCCTGTCATGTGTACCAGAAAACGATAGATGGTTCGCGAATAGCGATCGTAGATTGCCAGGAAAGCCTGATTGTCGCATTCTGATATATCTGCTTGCGCTGCAGTTTCAGAGTCGCGATCGGAGTGCCTTCCTTCGGCGCGCGCATCCGTTTTCGGCTGAAACCATAGCAACAATCTTTTCCTGTCTTGCATTGCAATCTTGACGCGAGAGACTTCCAAAATGCTCAGATTTTCTTTGGAAAATACGGAATAGAGCTTGCCCTGCGATGGTCGTTCGATGCACACGGCCTCTCTCTGTCAGAGGCGGTCGAAGTAGCCCCTTTGGAGGGTGGTTAATGCGCTCTTGCTGACCTTTACGGTGCTGTGTGCGAAGCTTGCTCTAAGCCGGAAGGCGAAGTCTCTTCCAGGTCGTCGGAGTTTCAGGTCTAAAGTTCGGTCTGGAAGCCGTGCCTTGAAAGATACTGAGATGGGGTCGAGCAACACGGCTAAACTGAAACGTCGGGAATTAGCGGCCCAATACGGATATCAGGCAGACCTATCTGTCCATGATGGTCGAGAATGGCCGGCGTCGTGTATCTCCTGATCTTGCTTCCTAAGCGTTGAAAGTCTTTGAGGCCCTGCAGCCGCATTGCCGCTCTCGATCTGAAAGAGCCCAAGCAGTAGACCGATGACGAATGGAAGATGCAGCTTGGAGCGCTGCGAGACCCCGGCTTTGCGTATCCGCGCGGAAAGCCTCGCCGCACTCCCGCACAAGTGCTCTTTTCAAGCCCTGAATAGAAGTGATCTGGATACGCGGGTCGTAGAAGCGCTTCCCTGGCTCGTCTTCACAGATGCAGACATGGACTGGGAGTGGCTGGTTCGGAACGCGAACCGCGCGCGTTTCGTCCTTCGGCGAGGCCGAAGATTGCAAAGGTGCCGGGATGCGGGGAGTGTCCATGGAGTAACCCGCCTCGCCACCAGCTTGCGCCAGCCGCTTTGGCACGTCAAGCACCCGACCGCAGAAAGATCTTGCCCATCTACGCGTTTACGCGCGTAAACGCATCGGCGTCGCAATCAATGCTCCGATCTCCAAGCAACTGAATCAACACGCGTTCACGCCTGCAAACCAAAACCGCAAGCCGGTTTACCGGCAGCAACCCTACTGGGGGTGACGTGTCGTAGCGTCAATCCCGTGCGCAAGCACGGAACCGGCAAGGTGTAGCGAATGCAAGAGTCGTACGGTGAGGGCCTAGCCAGCCACACCGGCTCCGAGTCTTGCGGATGTGGCCGTAAGGCCATGTACGAAGCGTAGACAGGAGGAACTACAGGCCAGGCTATTGAGCCGCGAAATATCCCTAACTTCAGGACGCCGACGCCTTGACACAACGCGGAAGGCAACATCCTGACAAGCAGTATGGCGAGCTTGGCAGGAGTCCTGCGCGGTCTATGACCCTGGCATGTAGGGACACACTTTGCACGGAAATTGAGAGATCCCGGGTTCACCTGAGAGCGGCCAGCGTTCTCGGGACGCATCGGGAAGTCTAAGGACAGGAGCCGATGATGAACGAACACGGGAAGTCGGACAGACTCATAGTACCGGGGAAGTCTCCGAACAAAGCCAGAGTATCGGTGGCGGAGGAGATGGAGGGAAGGGGTCTGACCAAGGGGAATCTGGGCCAACAAAACGCGCCCCGGACTCAGAGCCGGATCAAGGGGGTCCCCGGCGACAGGTCTTCGTCGCTGGGGTCTCTCAGCGCGCCAAGTGAGTTGGAACAGATACGACAAACGGCAAAATCGAACAAGGATGCAAGGTTCACTGCTCTGATGCATCATGTCTACCGGATCGACACCCTGCGGTTCGCCTACTTGCAGTTGAAGAGGCACGCTGCGGCGGGTGTGGACGGGGAGACATGGCGGCACTACGGCGAGGCTCTTGAGGAGAATCTCCAGAATCTCTCCCATAGACTGAAGCGCGGGGCATACCGGGCCAAGCCGGTGCGTAGGGTGTACATCCCGAAGGCGGATGGGCGGCAGCGACCGCTCGGCGTCCCGGCGCTCGAAGACAAGCTCGTTCAGAGAGCGACGGTGGAGGTACTGAATCAAATCTACGAAACCGACTTCCTCGGCTTCTCTTATGGGTTCCGTCCAAAGCGGCACCAGCATAAAGCGCTGGATGCGTTGTGGTGTGGACTCCATGAGCGACGTGTGAACTGGGTGCTGGACCTGGACGTGCGCAGCTTCTTCGACAGGCTGTCGCATGAATGGCTGGTCCGGTTCCTCCAGCATCGGATAGCGGACCGGCGCGTTGTGCGTCTCATCCAGAAATGGCTGAACGCGGGCGTGCTGGAAAAGGGCAAGCGAACCTTCGTGGAAGCAGGCTCGCCACAGGGCGGAAGTGCATCGCCCCTGTTGGCGAATATCTACCTCCACTACGTCTTCGATCTCTGGGTTCAGGCATGGCGTAAGAAGCGTGCGCACGGCGATGTAATCGTGGTGCGTTATGCGGACACATCGTGGTTGGGTTCGAGTACAAAGACGAGGCCGAACGGTTCTGGTTGGAACTGAAAGAACGAATGGAGAAGTTCCAACTGGAGCTGCACCCGGAGAAGACGCGGCTGATCGAGTTCGGACGCCATGCGGCGAAGAACCGAAAGCGCGCCGGTCTGGGCAAGCCGGAGACCTTCGACTTCCTCGGCTTCACGCATATCTGCGGGAAGACAAAGAAGGGAAGGTTCATGGTGCTTCGGCAGACGATTCGCAAGCGCATGCAGGCCAAGCTGCAAGAGGTGAAGATCGGCTTGTGGCGGCGCATGCATGACCCTGTTCCGGAAGTCGGAAAGTGGTTGAAGTCCGTTGTGGGCGGGCATATCCGATACTTCGGAGTGCCGGGCAACCGGCATGCTCTGGCCCATTTTCGTTACACCGTGAGCAACCTCTGGCATCGCGCTCTGTGCAGGCGAAGCCAGCATGGTCGCGTCAAGTGGGAACGAATGAAACGGCTCATCCGCAAATGGCTTCCTCCGGCCCATATCTGCCGTCCTTATCCTTCGCGCCGTCTGCGCGTCACCACCTGAGGTAAGAGCCGTATGCGGGAAATCCGCCCGTACGGATCTGTGCGGGGGGTACGGCGTAAGCCGTATCCCTACCGCGACTACGTACATCCGGTGCGGAGCACCGTTGTGGTTCCGGGAACGATATTTCGGTTGCATCAGCTCCTCGTACCCGCGACGGAATCCACCGAAGTGCTGCCGTTGGCAGCACGGCTTGCAGGCTTTCTCGGAGACTGCTCCGGTGAGTCATTGGGCGATGGTTTGCGAGTCCTCAGAGTGGGCGTGACGGTCTGCGCTTCGGAGGACTTCAGGAACTCCTGGAAGTCGCGGTCCTTCGAGAAGATGTAGGCGAGCGCCTGTTCGATGACTTCATCCGCTGTTGCATGGAGGAATGCGGCATACTGATCGAGTTGGGTAGCCGTCGTGTCGAGCAGCCGGATATAGGCGTTGATGTGCCGGGTTCGGGTGACTTCAAGCAGGGGCATTTGTGTTCTCCTTCGTGGGGTGCGTGTTCAGGCTGTTCTCTTGCGTGCGACCATACGCTCCGCTGTCGAGGCTATCTCTCTCGCTCGGACTGCACAGAGGGCGCGGGGAAACTCGAAGCGGCGACGCACTTCAAGCATGGTGATAACGCCGTCGATGCGGATGCCTTCGAGCAGCCAGAGATGAGCGGAAGCGACATCGATGGTGCGCTGGGCGTAGTAGACGGGGTTGGGCTTGTCGGAGCGCCGGGAAGCCAGTTCCCGCGTCAACTTCATGGCATCGGCTCCATGGGCGAGTTGCGCCGTGACCCAGGCCCAGTCCTTCTCGGAATTGCTGCGCTTGCCCTTATGGGGCGGAAGCGTATGACCGAATGACGTGCCTTCGGCTACTCCTCCGCCGACATGGAAGTCCTCTGTCAACGCCGTTTGAAAATTCCTCGTATTTGGGCGTTTGAAAATTCCCCACTTTTGGCAGGTTGAGATTTTGGATCAGGCCGGGAGTGTGCGGCGGAGGGCGTAGCCCGGAGCCGCATACTCCCGGAAGCCGGTCCAGGTTGGGGTCAGGCTCCTTCCCTGTTGGGGGTTTTGGCGGCGATCACCCCGGCCTTCTTCTTGTCCTTGAGCCGGTAGCTCTCGCCCTTGATGTTGATGGTGGTGGAGTGGTGCAGCAGACGATCCAGAATCGCCGACGCAATCACGTTGTCAGCGAAGATCGTGCCCCAGTCGCCATAGCTCTTGTTTGAGGTAACGATGATCGATCCCTTTTCATAGCGCTCGCTGACCAGCCGGAACAGGCAGGTGGCGGCGAAGGGATCCAGCGCCAGATAGCCCATTTCATCCAGGATCAGCAGCTTGGGCTTGACCAGCAGGGTCATCCGCTCCTTGAGCTTGTTCTCGTCGCGGGCGCGCTGGAACTGCTGCACCAGGTCCTGCACGGTGACGAAGTAGACCGTGTTTCCGGCCACGATGGCCTCGGTGCCGAGCGCGATGGCCAGATGCGTTTTACCCACTCCGGGCGGGCCGAGCAGCAGCACGTTCTCCTTACGTTCCAGAAACGCCAGACCGGCCAGCTCGCGCAGTTTGCGCTCGTCGACCGAGGGCTGGAAGTCGAAATCGAACTGGTCCAGGCCCTTGTTGTAGGGGAAATGCGCCCATTGGGTCTTCAGGCGCACGTTGCGCGTGTGCTTGGCCTGGCTCTCGGCTTCCAGGGCCTGCTCCAGGAAATCCAGATAGGGCAGGTCCTTGGCTGAAGCCTCTTCGGCGATGGCTTCATAGCAGTTAGGCAGGTGCGACAAGCGCAGCCGCTGCATGTGGTTGAGCAGACGTTCAGACTGTAGCGACATGGGCCACCTCCTCGTAGATATCCAGCGAGCGGAGCTCCACCACGGGCACGGGATGATGCAAGCCGACGCCGGGACCGGGCGTTAGCTCCGTGGTTGGCGCTGATATCGGAGCCGTTGATCTACGGACCCTGCGCGGCAAGCCGGCATAGTGCGCCGGGTCGATGACCGCCTGGCCCTTGCCTGTGGCCATGCGGTGTTCGGCGATCAGGTCCCGCTGATGAAAGATGCGGATGACGCGCACATCCAGAGGTTCCCGTACCGCCACGCTCTTGCCGGCATACGCATGCGGCACCGAATAGCGGTTGCCGCGATAACTCAGCAGGCAATCCTTCGCCACCTGGCGATGGCTGAGGTAACTGGTATCGTAATCCGGCTGGCCGCCGAGTGGCGTCAACCCTTCTCGCGCAAACCGCTCCAGAGGAACCTCGCGCGTGGTTCCATGCACGCGCCGGTTGGCTTCTTCGCACCACACCAGCGCTTGATGGTTCAACTCCGGCAGGGAATCGAAGCTCGTCCCCGGCCAGAAACTCGACTTGATGTACCGGATCGTAGACTCAATCTTGCCCTTCGTCTCCGGCCGGTAAAGATGACAGACCCGCGGCACGAAGCCGTAGTAACTGGCAAAATCCAGCATCTTCGTATGAAAGCGTGGCTGCCCATCGATGCGGTCCAGCACCACCGTCTTCATGTTGTCGGTCAGCACCGTCGCTGTGACTCCACCGAAATGCCGGAAGGCATGCACCATGCAGTTGAGAAGTGTCTCCACATCCTGCCGCTGTGTGAACTCCGCGTACTGCATCCGCGACCAGCCCAGCGTCAGCGCAAATCCGTACAGCCGCCTGCCGCCCCAGTTGCCGAAATGACCCCAGTCCATCTGCGCCTGTTCGCCCGGCTCCGTCTCGAAACGCACAAACGCCCGCTCCCGGTCTTCGCTTCGCCACTCCCGCACCGTCGTTTTCACTTGCGTGTAACAGCCGTCATAGCCTCACTTGCGCATCTCCATAAATAACCGGCTGGCGTTATGCACGCCCTGCTCCCAGCGCTCCCGCAGCCAGGGCCGCCAGGGATCGATCTTCCAGCTCTTCGGCTTGCGTTCATACGCCCGCGGCGCTTCCCGCAGGTACTTCCGCACCGTCTTGCGGTCGATGCTCAGATGCCGGGCGATCTCCGTCACGCTCCAGCCCTCATGATGCAGCTTCTGTATCTCCATGAAATCCTCCAGTCGCAGCATCCTTCATCCTCCCGGATCAGAATGCCGCCGCTCGGCCTACACCGGGGATTTTTCAAACGCCACTTTTGAGGATTATTCAGACGGCGCTAACAGACGAATTTCCTCGGCTTCTCCTACGGGTTCCGGCCCGGACGCAGCCAGCATCAAGCGCTGGATGCTCTGTGGTGCGGGCTCGACGGGAGACGTGTGAACTGGGTGCTGGACCTGGACGTGCGCAGCTTCTTTGATACGCTGTCGCACGCATGGCTGGTCCAATTCCTCCAGCACCGGATAGCGGACCGGCGCGTCGTGCGTCTCATCCAGAAATGGCTGAACGCGGGCGTGCTGGAAGAGGGTAAGCGAACGCAGGTGGAGATGGGTTCTCCGCAGGGCGGAAGTGCATCGCCACTGCTGGCGAATCTCTACCTCCATTACGTCTTCGATCTCTGGGTTCAAACATGGCGTCAAAAGCGTGCGCACGGCGAGGTGATCGTGGTGCGTTACGCCGATGACATCGTGGTCGGGTTCGAGTTCAAAGACGAGGCCGAACGGTTCTGGTTAGAACTGAAAGAGCGAATGGAAAAGTTCCAACTGGAGCTGCACCCGGAGAAGACGCGACTGATCGAGTTCGGACGCCATGCGGCGGCCAATCGAAAGCGTGCCGGTCTGGGTAAACCGGAGACCTTTTCCTTCCTCGGCTTCACGCATATCTGCGGGAAGACGAAGAGGGGAAGGTTCATGGTGCTTCGGCAGACAGTTCGCAAGCGCATGCAGGCGACGTTGCAGCGGATCAAGACCGAGTTGCGACAACGCATGCATGACCCTGTTCCTGAAGTTGGCGAGTGGTTGAAATCCGTCGTGGGCGGGCATATTCGATACTTCGGAGTGCCGGGCAACCGGTATGCTCTGGCCCACTTCCGCCTCACGGTCAGTCGTCTCTGGCAGCGCGCTCTCACGCGGCGAAGTCAGAAAGGACGTGTGCCGTGGGAGCGGATGCAACGGCTCATCCGCCGCTGGCTTCCTCCGGCCCATATCTATCATCCCTATCCCTCGCGCCGTCTGCGCGTCATCACCTGAGGCAAGAGCCGGATGCGGGAAATCCGCCCGTCCGGATCTGTGCGGGGGGTACGGCGAAAGCCGTATCCCTACCGCGACGTTGCGTCAATCCCGTGCGCAAGCACGGAACCGGCAAGGTGTAGCGAATGCAAGAGTCGTACGGTGAGGGCCTAGCCCGCATATCTCACAGGTGGACTGTTGAAGAGGAGAGTCAGCGGGCTGAGCTGGCCCCTTGGTTTAGTCCGGTTAAGTGAGAGCACTCGCGGTTGAGTTTAGCAGCGATGGATTATCGCCGCAGTCGGGGCTGTGCGGATGTGGGAAGCGCGTAGCGGTTTCCACATCCGCACAGCCCCTGCGAAATTCCTCCGGGGTCAGATATCCGAGCGAGCTGTGAGGGCGTACCCAATTGTAATCAATCCGCCAGCTTTCGATGGTTTGCCGAGCATCGTCCAGCATCAGGAACCAGTGTTCGTTCAGGCACTCCTCGCGGAACTTGCCGTGGAACGATTCGATGTAGCCGTTCTCCATCGGGAGACCGGGCGTGATGAAGTGCAGCGTAACCTGGTTCTTGTAAGCCCACTGGTCCAGCAGCTTCGAAGTGAACTCCGTCCCATGATCGATGACGATCCGCTCGGGCAGTCCGCGTTCCAGGCGGAGTCTCTCCAAAACGCGGACCACGCGCAGCGCCGGCAGGGATGTATCGACCTCGATGGCCAGCATCTCCCGCGTGTATGCATCCTCGATCGACAGAGTGCGCAGCTTGCGGCCGTTGGCCAGAGCATCGTGCAGGAAATCCATCGTCCAGGTCTCGTTCAGCCGAGTGGGCGGCAACAGCGGCACCCGCGCCTGGGCGCAGACCCTCCGTCGGCGTCGCCTCCGTCGCACCACCAGCTTCTCCTCCACGTAGATCCGGTACACCCGCTTGCTGTTCACCTTCCAGCCCTCCCGCTTCAACAAAATGTGCAGCCGCCGGTAGCCCCAGCGCCGCCGCTCGTCGGCCAACTCCCGCAACCGCTTGCGCAGCTTCTCGTTGGCAGCCTCGTATCGACTGGCCCGCGGCCGATACCGCACCATCGCGCGCACGACTTCCAATTGCCCACAGGCCCGCCGCTCCGAAGACTTCGTTGCCTCACGAAAGACCCGAACGGCTTCTCGCTCCGCCTGTGGGCCTACCACTTTTTTGACAGCACCGCCTTGAAGCCCACAATATCCAGCGCCTGCTCGGCCACCAACTGCTTCAGCTTGCGGTTCTCCTCTTCCAGATGCCGCAGCCGCTGCGCATCGCTGACCTCCAGGCCGCCGTACTTCGCCTTCCAGCGATAGAACGTCTGCTGGCTGATCCCATGCTTGCGGCATAGCTCCGCTGTATCGAGCCCTGCTTCGGACTCCTTCAGAACTCCTACAATCTGCTCTTCTGTGTACCGGCTCTTCTTCATCCGTTCTCCTCGTCGGCCTCCAACTGCTGGCCTTCATTATCGGAGAACTCTCACAACCTGTGGACTAATCGGAGGGGTGCAGCTCACACCTGCGTGGAACCGACATATTTGTCCAGCGCGCCCTCAACGACCGCGCGCAGCTTCCTGGGACGCGCAGCGCTGATCTCCCCACGCTTCGCCCGCGCCTCCTGCGTCAGCAGATACTCTCTGCCCACCTCGCGAAACGGATGGTTGAACACCGGAACGTCATGCTTGATCCGAAAGCGAATATCCGCATCCTGGTCAAAGGCCCGTTCCCGCGCCACATCGATGTCGGTCGTTTTGAGCGAAACCGTCTTGTAGCGGTCAGCCTTCGGCATCTTCATGCGGCAATACCACATGCGATGGTCCACATCGCCGCGCCGAAAGAGGATCAGCCCCGGCTTGAGTTCCGTTTTGTCGGTGACGAATGCCATATTCGCCTCCCTCATTTGGACGCGTTCTGTGCAGATTCCGTGTAGGAATTTTTCGCAAGTCGTTGAATTTAGGTTTCTGTGCAGGACTCGTGCAGTAATTATCAAAATACTATGTCTATTACTGCCAGTTATTTACGATGTAATTGTCATCCCGGCCAAACCAAGTGCACCGGGGTCCCCACGAACAGGTCCTCGTTCGTGGGGTGGCGAGTGGAGGGACCTGCATTCCCATCCCGAACTCCACCCCCACTCGCGATGCGTCATTCTGAGCTGCGAAGCGGCGAAGAATCCCGGCGATGCCTCCATCCCGGATGCTGTCGCAAGTTTCTCCCAGCATCCCCCGCCACGCCCCTCCCGGCGTCCGCAGCGAGCACGCCCCACAACTGACCACTGGGGACTGACAACTGACAACTGACAACTGGCAACTGGCAACTGGCAACTGACAACTGACAACAGACCACCCGTTTGCCCGCTCCTCTGAGCGTCCGCTACACTGGCATGTCACCTGTTTTTGCTTGTTCTGCGCGGTCTTTCCGCGTGCATTTTGGTCTGCGGTCTCTACTTACAGCACTTTTTAATCCACTGAACAGGAAGCGTTCTGCCGGAAATTCCCTATGAAAATTCATGAGTATCAGGCGAAGGACATCCTGGCGAAGTACGGCGTTGCCGTACCCCGGGGTGAGGTGGCCAACACGCTCGAAGAAGCGATGGATGTGGCCAAGCGGCTCTTTGCCGAGGGCGCGAAGGGCGTCGTCGTCAAGGCGCAGATTCACGCCGGAGGCCGCGGCAAGGGCGGCGGCGTCAAGGTTGCCAAAACCCTCGAAGAGGCTGAGCAGTACGCCAAGCAGATTCTCGGCATGCAGCTCGTCACCCACCAGACCGGCCCCCAGGGCCAAAAGGTGCAGCGCCTGCTCATCGAAGAGACCGCGGCCATTGATCGCGAACTCTACCTCGGCATCGTGCTCGACCGCGCAGCCGCCAAACTGGTCTTCATGGCCTCGCAGGCCGGCGGCATGGAAATTGAAGAAGTCGCCGCCAAAGATCCCTCGGCCATCTTTAAGGCCTATATTGATCCGGCCGTCGGCTTCCAGGCCTACCAGGCGCGCCAGTTGGCCTTCGCCCTCGGCCTCAAGCCCACCCAGATCAACGACGCCGTCAAATTCATGATGGGCCTCTACAAGGCCTATATGGATACCGACGCCTCGCTGCTTGAAATCAATCCCTTCATCACCACTAAGGACGACAAGCTCTTCGCCCTCGACTGCAAGATCAACTTCGACGACAACGCCATGTTCCGTCACAAGGACCTCAAGGAACTCCGCGACATCGCCGAAGAAGACCCCCTCGAAGTCGAAGCCTCCAAGTACGCCCTCAACTACATCAAGCTCGACGGCAACATCGCCTGCATGGTCAACGGCGCCGGTCTGGCCATGGCCACCATGGACATCATCCAGTACGCCGGCGGCATGCCCGCCAACTTCCTCGACGTGGGCGGCGGCGCCAACCAGCAGCAGATCGAGCACGCCTTCGAGATTCTGCTCTCTGACAAAAACGTGCAGGCCGTCTTCATCAACATCTTCGGCGGCATCCTGCGTGTGGACACCCTCGCGCACGGCGTCGTCGGCGCGGCACAGAAGCTCAACGTCAAGGTGCCGATCGTGCTGCGCCTCGAAGGCACCAATGTCGAAGAAGGCCGCAAGATCCTCAAGGACAGCGGACTCAATTTCATTGTTGGTGACACCATGCAAGACGCCGCGCAAAAAGTAGTCGCAGCAGCCAAGGGACAGTAGCTATTAGCTTCTAGCCCTTGGCCTTTAGCTGTTAGCCAAAATACAATGGCGCAGAATTTTCAAGAGCTTTTGGTATGGTAACGCGCGATGGAAATGACGGTCGCTGTTTATGAGTTCAGCCGGTCATTTCCTCGCGACGAACTCTACGGATTGACTTCCCAACTGCGAAGGGCCGCGGTTTCGGTCGCAAGTAACATCGCCGAGGGAAGAGGACGGCTGTCAGACGGCGAGTTCCGGCAGTTTCTCGGCCTCGCACAAGGATCAAATTATGAGGTTCAAACCCAGCTTCTTGTCGCAAAGCGGTTGAAGATGGGGGAGCCGGAACAATTACGCAAAGCTGAGTCTCTAAGTCTGGAGACAGGGAAGATGCTCAGCGGATTGATCGCTTCGCTCGGTGCTAAGAGCTAGAAGCTAGGAGCTAAAAGCTTATGGCTGTACTGGTAAATAAAGAAACCCGACTCATCGTCCAAGGAATTACCGGCAAGGAAGGCACCTTCCACGCGAAGGGTTGCGCCGAGTACGGAACCAAGGTCGTCGGCGGTGTCACGCCCGGCAAGGGCGGCACCACGCATGAGGGCTGGCCGGTGTTTGACACCGTGCAGAAGGCCGTCGAAGAAACCGGCGCCAACGCCACCGTCATCTTCGTGCCGCCGCCGTTCGCGGCTGACGCCATTCTCGAAGCCAATGAGGCTGGCCTGCCCCTCATCATCTGCATCACCGAGGGCATCCCCGTCAATGACATGGTCAAGGTCTGGAGCGTGCTCAAGCACTCCAAATCCACCCTCGTCGGCCCCAACTGCCCCGGCGTCATCTCGCCCGGTAAGGCCAAAATCGGCATCATGCCCGGCCGCATTCATAAGGAAGGCAACGTCGGCATCGTCTCCCGCTCGGGCACGCTGACCTACGAGGCCGTTTACCAGCTCACGCAGCGCGGCATCGGCCAGTCCACCGCCATCGGCATCGGCGGCGACCCCATCATCGGCACCACCCACGTAGACGCTCTCAAGCTGCTCAACGAAGACTCCGAAACCGAGGCCATCATCCTCATCGGTGAAATCGGCGGCACCGCCGAAGAAACCGCTGCGGAGTACGTCAGGAACCACGTCAAGAAGCCGGTCGTCGGCTTCATCGCCGGTCAAACCGCGCCTCCGGGCCGCCGCATGGGCCACGCCGGAGCCATCATCTCCGGCGGACAGGGCACTGCCGCCGAAAAGATGAAGGCGCTCACCGCCGCCGGCATCCACGTTGTCCAGTCGCCGGCCGAAATCGGCGAAACCGTCGCCCGCGTCATCGGCAAAGCATAATTCCGTTCAAGAAGCCCCTCAAAGGCACTTTGGCTCTCATGTCAAAGTGCCTTTTTATTGCACTCGAAGCCGATGTACATGATTAACATTATAGGTGTACATTAAAGTACATGGAAGTCCCCATCACTAAATTCCGCCATGACCTCTTTGACCTCGTCCAGCAGGCGATGGAAGGCAACGAAGTCTGGGTCCGCTACAAGGGCCGCCGCTTCCGCATCGCGCCAGAGGGTAGCGTGGGCAGCCGCATCTCGCGCGTCACTCCTCTGCAGGTGCTCAATCCCGAAGCCTCGCCCGAGGAGCCGGCCCTGCTCGAAGAGATGACCCGCGCCTGGGAGAAGGACTGGTCCGCTCTGTGATTGCCTACCTCGACACGAATGTCGTGGTCTGGCTGGCACAGGGCGACCTCAGCCGCATCTCCGCCCCCGCTCTGGCCGTTCTTGAGGAAGCGGACCTGCGCATCTCTCCCATGGTGCTCATTGAGCTTGAATACCTCCACGAAGTGCGCCGGATACTCCTCTCCTCCCGTGAAATTCTGCTGAAAATCGAGCACGAGCTGGGCGTCGAGGTCTGCAATCTCTCCTTCCCGCGCGTCGCTCAGGTCGTTCTCGACGAAAAGTGGACCCGCGACCCCTTTGATCGCACCATCGTGGCCCACGCCAAAGCCAACGGCCTGGCATCTCTCGTCACAGCCGACGAAGAGATCAGAAAGCACTATCCCAAAGCCGTCTGGTAACCAATCGCGGCCTTCTCTCGCATACACTGGTACTAACGCATTTTTTTCAAGGAGAACCCCAGGTGTCCCAACGCACCTTCAGCATCATCAAGCCAGACGCGGTCCGCAAGGGCCACACCGGAGCCATCCTCGCCGAGATCGAGAAGGCCGGTTTCAAGATCGTCGCCATCAAGAAAGTCTCCATCTCCAAGGCGCAGGCCGAGGGCTTCTATTACGTGCACAAAGAGCGTCCCTTCTTCGGCTCGCTGACTGACTTCATGTCCTCCGGCCCCATCTTCCCCATGGTGCTTGAGAAGGACAACGCCATCGCCGACCTCCGCAAGCTCATGGGCGCCACCAACCCGGCCAACGCCGAGGAAGGCACCATCCGCAAGAAGTTCGCTGGCTCCATCGAAGAGAACGCCATCCACGGCTCCGACGCCGAAGAGACCGCCGCCTTTGAAATCGGCTACTTCTTCGCCGGCTGCGAACTGGTCTAGCCTCCCATCCTCGTCCGCCTTGCGCGGGCACAGCTTCGGGCGCTGCGAAAACGTAGCGCCCGTTCTGTTTGTGCCGTCACACGCGCCCGCACTCTCGCGCAACGCGACTTGCCGGCTCACATCCAACAGGTGCCATGACTGACCATCTCTCGACTCTGCAAAACCGCATTCAACCCTACCGCGCGCAACTGGCCGAGCACCCGCTTTACGCCTCGCTCGAGACACTCGAAGACCTCCGCCTGCTCATGCAGTCGCACGTCTTCGCGGTCTGGGACTTCATGTCCCTCCTCAAGTCTCTGCAGCGCACTCTCACCTCGGTCGACGTGCCCTGGCAGCCCACCGCCGATGCCGCCGCCCGCCGCTTTGTCAATGAGATCGTCCTCGGCGAAGAGAGCGACCACCACAACGGCCGCACCTTCAGCCACTTTGAGCTTTACCTTGAGGCCATGCAGCAAAGCGGAGCCGGCACGCGTCCCGTGCAGAGCTTCATCTCAGCCCTGCGCGCCGGGCAAAGCGTCGAACAGGCCCTTTCCTTCACGCCCGTTCCCGCCGCGGCCGCGAACTTTGTGCGCAGCACCTTCGCGGTGATCGAGGCCGGCTCCTTGCCCGCCATCGCCGCCGCCTTCACCTTCGGGCGCGAAGACCTCATCCCCGACATGTTCCGCGGCTTCGTGCGCGAGCTGAACGCCACAAAGCCCGGCCAGGTCGAAACCTTCCTCTTCTACCTTGAGCGCCACATCGAGCTTGACGGAGACGATCACGGCCCGCTGGCCCTGCGCCTCATCCAGTCCCTTTGCGCCGACGACGCCACCCGCTGGCAAGAGGCCACCCACGCGGCAGAGGCCGCGCTCAAGGCCCGCCTCGCCCTCTGGGACGCCATCTACGCCGAGGTCATCACCCGCCAATACGCCCCCGTCGCCTCCTAGTTTCCAGCCCGGCGCCCCGGGTCCACGTGCCCCGGGCCCGTCCGTCCGGACCCGGATCACGGCTGCTCTCGAAAGTTTCTCCCATCCTGCTTTGTGTCACTGCCAGTTGTCATCAGAATCTCTGCCCAGGGCGCCGAAGGCGCGTGCGCCCGGACGGCCAGTCCCGCCCGTCCCCAAGTATGCTGGTGTGCATGGAATTCTTTACCCTCAACGGCGCGCAGGTTTCGCGCATCGGTCTCGGCACCTGGGCCATCGGCGGCAGTGAGTGGGGCGCGGTCCCCGAGGCCGACGCCATCGCCACCTGCCTCGCCATCTTCGATCACGGCATCAACCTCATTGACACCGCGCCCATCTACGGCTTTGGCCGCTCTGAACAGCTCATCGGCAAAGCCATCCGCCAGCACGGCCGCCGTCAGGACTTCTACATCGCCACCAAGGCCGGCCTCGAATGGAACGATCGCGGCGTCTTCTCCAACTCTGATCCCGCCCGCCTCCGGCAGGAGTTTGAGGACTCGCTCCGCCGCCTCGGCACTGACTACGTGGATCTCTACCAGATCCACTGGCCCGACACCACTCTGCCCGTCGAGCGCGCCGCCGAGGTGCTCCGCCAGCTCTTCGACGCGGGCCGCATCCGCGCCGTCGGCGTCAGCAACTTTTCCGCCGCGCAAATGGACGCCTTCTCAAAGATCGTCCCCCTGCACTCCAACCAGCCGCCCTACAACCTCTTCGAGCGCGAAATCGACGCGAGCACTCTGCCTTATTGCCACAGCCACAACATCGCCGTGCTCACCTACAGTTCGCTCTGCCGCAGCCTGCTCGCCGGCCGCCTCAAAGCCGATACGCCCATCCCCGAGGGCGACATTCGCCGCGAAGACCCCAAATTCCAGCTGCCCCGCTTCGCCCAGTACCTGCAGGCTGTCCAGCAGCTCGACGCCTTTGCCCAGCAGCACTACGGCAAGCGCGTGCTTCATCTGGCCGTGCGCTGGGTTCTCGACCGTCCCGGCATCTCCGCCGCCCTCTGGGGAGCCAAGCGCCCCGAGCAACTCGCGCCCATCCCCGAAGTCATGGGCTGGCATCTCGATGCCTCCGCCATGGCCGAGATCGATCGCATCGTCGCCGCCTGCGTTACCGATCCCGTCGGCCCCGAATACCTCACCCCCGGCGTCCGCACCTAAGCGGCAACGGGTGCCCCACGTCTCGCTTCTGAGACGTGGGATTCAAAGTTCCGAGTGCGCCGGGTGCCCCATTCAAGCCTGGTTTTGGCTTGAGTGGGGTTGCTTCTTTTGCCTCGCAGAACACCTGTATCAGGGCACGGCTTCAGCCGTGCCGGTAAGCAGCCAATAGGGACGGGCTTCAGCCCCTGCATCCCACCCACCTTTGTCATCCCGGCCAAACGAAGTCAGTGAAGGCCGGGTGCCTGTAGAAGGTCAAGAGGTTGTTCCTTCTTGGGATCGGCTGCTTGGCGGTTTGTAGTTGAGGCTACCATGAGGTCTTTCGTGGTTGTAGTAGTGGATCCAGGACTGCAAGTGTTGATCTCTCTGGCTGGAGTCGGTCCAGTGTTTGGCGTAAGCCCATTCGCGCATGGCTGTCTGGATGAAGCGCTCGGCCTTGCCGTTGGTTCTGGGGGTATAGGGCCGAGTGCGGCTGTGTTTGATGGCCATCTGCTGGCAAGCCTGACGGAACTGGCGAGAGCGGTAGCTGCTGCCGTTGTCGGTCAGCAGCGCGCGGATGCCGATACCATGGCTGGCGAAAAACTCAACCGCCGCGTGCAGAAAACCGATCGTGGTTTCCGCCTTCTGATCGGCCAGCATCTGGGCGAAGACCATGCGCGAGTGATCGTCGACGGCCACATGCAGAGCCAAAAAGCCCGGGTGTTCCTTCTTGCCCCGCAGCCTGCCGTCGCCGCGCAGCGAGACCTCGCCGAAGCGCGTCATGCCTTTGATGTCCAGATGCAGCAAGTCGCCTGGAGCGGCATGCTCATAGCGAACCACCGGCGGAGGCGGGTTCAGATCGCGCCATCGGCTCAGCCGCGCGCGCCGCAAAATACGGCTCACCGAAGACACGCTCACAGCGCTGCGCCGGGCGATCTGATACCCCGGCATGTAACCCCGCCGTAGCTCAATCACACTCAGCCGCAACGCCTCCGGCAAGCGCCGCGGGCTGCGATGCGGACGCGAGCTGCGGTCCCGCAAGCCATCCGAACCCTCGGCGCGATACCGGCGCACCCATTTGCCGGCCGTCTTTGCGCTCACGTTGAAGCTGGCCGCGGCCAGCTTCAACGTGCACCCGGTACAAATAACTTTTCTCGCCAACTGCTCTCGACTGTAAGGCGTTAGACGAGCATTCTGGTGAATGTCCATTCGATCTCTCCGAAGACTCTGCTTGTTCGCCACAAACAGCTTCTCCGCGAAATTTCGAATGGACAACCTCTTGAAACATCACAGGTGCCCCACATCTCGCCTTTGAGATGTGGGTTTCTCCGTCTCACTGCGCTCGATCAACGAACCATCAGATACGCGGCCAGGCTCCGCAGCATCTCCTGAAACACCGCGTCGTCGTCCATCTCCAGCACCCGCTCCCACACCGACTCACCCGCCAGCGTAATCGTCTCAAACGCCGTTCCTGCCTGCATCATCGCAAAGCGCAGTGCTTTCTCCGGCTCTGGATGCCGAATCTCGTTCCGGTAAACCATCAGAAGATCCACCAGCAGCATGTAGCTGTCGGCAATCAGGTTCGCCGCCTGCTTCTGAAAAGCCTTGTCCTCGGACTGCTCCAGAAACTGCCGCAGAGCCCTCCGCGCCGCCTGTGTCTGCCGGTTCTGCGAATACATCGCCGCCATCATCGCGGGCAGCGCCTGCGCAAAGGGAATCCCCTCCAGCTTCTCCGCCGTCAACTCCTCGCGATTGGTCCGCGCCGCGTGCTCCAGCATGTCCAGAAAAGCCGCCTGCAGCAGCGCGTCCTTGTCTTCAAAGCGCCGGTACACATTCGCTGCCGAAACCCCCGCGGCCTCGGCAATCTTCGGGATGGTCGCGCTCTGCAGCCCCTGCTTGCTCACCACCTTGATGGCCGCATGCATCAACTTCCGGTGCGTCTCCTGGCTGCGCTCCTGCTGCGGCGCAAATCCGGCGCTCGCCGCCGCCTTCTTCTGGCTTGCCTTGCCGCCCGCTTTCACCTTGGGCTTCGCGGCCGCCGCACGAGGCTTCGCCGTCTTTTTCGCCGCCGCCTTCGCCTCGGTTTTCGTCGTAGCCTTTGTAGCAGCCTTCGTCGCAGTCTTCGCCGTAGTCTTTCCGGCTGCCGAAGCAGTCTTTTTCGCGGCTGGGCGCGCAGCTTTCTTTTGAGCGGATTTGGCAGCGCGGGCTCCGGCTTTCACCGGCTTGCGCGACGACTTTGAGGAGGGTTTGGGCGTCATGCCCACCAGTCTAGCCACGAATTCATCCAAAAAGCGAATCCGCATTCACTTTTCTCGCCCGCCGGTACCGGAACCGCATCCCTCCCGCCCCCTGTTACCCTGGCTGGAGCAACACCCGTCCCCTTGTCATCCCGGCCAAACGAAGTGAACCGGGTGCCCCACATCTCAAAGAGATGTGGGTGAAAAGCCCAATCAATCGAACCCTCTGTATCAGGGCATGGCCTTAACCCCTGTTGAAGGGTACGGGCTTCAGCCCGTACATCCCCACCGAAAAAAGACGGGGCTTCAGCCCTGAGGGAATGCCCTCACCCACGGATGCGTCATTCTGAGCGAAGCGAAGAATCCCGGCGATTCCTCGGATTCAAACACCGCCCGAAGTTTCTCCCACCATTCCCGTCGCATCCCTGTATCAGGGCATGGCTTCAGCCATGCCGCAAAATGCTTGTAAAAGAAGGGGCTTCAGCCCCTGACGGGTACGGGCTTCAGCCCGTACATAGCCCCGCAAAAGACACCGGGCTTTAGCCCCTGAGGGAATTCCCGCCCTCACCCCCAGTTGCCTTACTTCTCATTCTCTGCGTCCCTTTGATTGATAAGTGTTTTATAATCAATCGTTTATGTGACATCAATCGAGCAGGGAATGCAAATGTGAATGAGCATTCGCTTTTATGGGCGCCGCGCTTAATCATGTAAGCCTATTTATATCAATTACTTGAACGACAAATTGGCTTCACTGCGGCTTCTCGAAAAAAGCCCCTCGCAAAACCCCTTCAAAAAGAGAATCCCAATTCACATTTCCGGCGATGCCGAATAAACCTCAATCCGTCAATCTTTTACACGAGGCCTTATCCGCGCATTTCGCCCAGCGGCAGAAAAAATGCGATTCCGCATTCACTTTCCCTGCAAAATACCCATAACCCGCTGTTTTTCAATCGCATACGGAGAAAATTTACGCAAAACCACGCCGCAAATGCGATTCTGCATTCACATTCCGGCCCGCACCACCCGGGAGACAGCCCGCAGCACCGCCTTGCCCGCAATCTCCCCCGCCGGGCTGGCAAAGACCATCTCGCCCACCCGCTTGGTCTGCGGCCTATAAAACCACCGCTTGAACAACGCCAGATGATCGGCCAGCATCGCTGAGGACGGCTTCTTCAGCCGCTCACGCAGCGCCGCGAGCGCCTCCTCCAGACGCCGGTCCAACTCATCGCGGCTCGCCGCCGGCACCGGCTCGCCCTCCGCCCGCAACGGCACCGGCTCCACCATCGTCGGGTGCGCAAACAGCGACGACGAGCCGGACTGCTCATTCGGGTGCCGCATCCCCAGCGTCGAAAAGAGCGCCGGCCCCGCCATCTGGCCGCCCTCCAGCAGAAACAGCGCCACCGTCTCCGGCTCTACCGACGGCTGCACCATCACGCCGTGCAACTGCGTCAGCGGCCGCACCGCCTCCGGCAGCGCGCCCATCACCTCGTCCACGCGCTCCACCCGGGCATGCACCTCGGCGGCCTTCTCAAAGTCCAGCGCCTCTGAGGCGGCTTCGCGCTCGGCCGCCAGCCGGGCCCGCAGGCTCTCGCCCCGCGTCGCCAGAAAGTCATGCACCGCCGCGGCTTCCTCGTCATAGCGGGCCCGCGTGCAGCCTTCAAAGCAGGGCGCCAGGCACTTTCTCATCTCCGAATAAATGCACCCGGCAAACGCCGGGTCCGGCTCTAAATCCTCCTGGCAGCGCCGCAGCAGAAACAGGTTCAGCATCTGCTCCAGCCACCTTTCCGCCATCCATCGCGAAGGGAAGGGCCCAAACAGGTCCTCGGCCGCCTTCAGCGTCAGCCGCGTTGCCGGATACACGCGCGGAAACTCATTCTGCATCGACATCCGCAAGAAGACCGGCGCGCGCAGATGCATGCGCTCCCGCGCCCGCTCGCCCATCGCCTCCACCGACGCCTGGTACAGGCACAGCAGCGCCTCAAACTCTGATCCGGTGCGCGTGTACTCAATGCGGCGAATCTGCGCCGCCAGTTGCAGCCGCTTCGACTGCTCCGGCTTGGGGTCCAGCAGCCGCTTCAGCCGCCGCCGCAGATCGGGCGTGCGATTCAGATAGGGCTCCGCCCGCTCATCCGCGCCAAACAGCGCAAACACGCCCGCTTCGGCAGGAATCTCGCTCCACGGCGGATTCTTCACATCAAAGGCCAGCGAGTGCGTCAACATCCAGGGCTCCCGCCCTCCAGCTTACCGAATCCGTGAGGGAAGCGAAGACGGCGGCTCGTTCGCAGGAAGGTTCCGGTGCCCCGTTCAAGCCTGCCGTTGGCTTGAGTGGGATAGTTCCACTTAAATTCTCATCCCGACCGAGCAAAGCGAGTGGAGCGACCTGCATGACCTCTCCCCCGCCAACTCCGGCAGTGCCTACCCGCAAGCAACGCGAGCGCAGAGAGAACCGGCACCAGAAGGCGCCGAAGGCGCGTACACCTGGATGGTCAGTCCCTCCCGGAGATGGTCATGCCGTCCACGCGCAGCGTCGGCGCCGAGGTTGAGCTGCGAAACACCAGGTCATTGCCCATCGCGGAGATGTTCTGCAGCATGTCTTTCAAGTTCCCCGCCACCGTAACCTCCTGCACCGGGAAGGCCAGCTCGCCATTCTCAATCCACAGCCCGGCCGCGCCACGGGAGTAGTCGCCGGTGACCATGTTCACGCCGCGCCCCATCAGCCGCGTCACATAAAAGCCCGTGCCCACCTGCCGCAGAATCTCTTCCGGCGTCGTCGTTCCGGCTTCCATGAAAAGGTTGTGTGAGGCCGTGTAGGGGTTGCCCGCCAGCCCGCGCCCCGCGTTGCCCGTGCTCTGCATCTTCAGCTTGCGCGCCGTGTAGCTGTGCAGCACATAGCTCTTCAGCACTCCGTTCTCCACCAGCACATTGCGCCGCGTCGGCAGTCCCTCGCCGTCAAAGGGGCGGGTGCCAAACCCTCCGGGAATCGTCCCGTCATCCACCACCGTCAGCCCCGGCACGGCAATCGTCTCGCCCAGCTTGCCGGCTAGAAAGGACGCTCCGCGCCACACCGCATCGCCGCTCACCGCGTCAAAAATCGCGCCCACCAGCCCGCCTGCCAGTTCCGGCGCAAACACTACCGGAGCCTGCTGCGTCTTCACGCGCCGCGCGTCCAGCATGCGCAGCGTACGCTCGGCCGCAATGCGGCCCACCTCTTCAGGAGAGTCGAGCTTCGCGAGCGAGCGCGCATTCGAGTACCAGTAGTCGCGCTGCATCTCGCCGTCCTTGCCCTGCGCGATGGGGCTCGCCACCACCGAGCAATACGAAGACCGGTACTCCCCGGCAAATCCCCGCGAATTGGCAAACGCCATGCGCCCGGTGGCCGCGTCAAAGCTCGCGCCATCGCTGTTCACCAGCCGCGCATCGCCCGCCAGCGAAGCGGCCTCGGCGCGCTTGGCATAGGCAATGCGCTCCTCGGTTGGCAGCGAATACACATCGTCAAAGTACAGCTCCAGATCGCCGTCCAGTTGCCCAAAGCTGCCCGGCTCCGGAAGCCCCGCAAACGGATCTTCCGAGGTCACCTGCGCCAGCGCCATCGCGCCGCGCACCAGGTGTTCAAGGCCATCCGGGGTAAGGTCGCTCGACGAACTGCTGGCCACGCGATAACCGTTCTCGCCCGCCACCAGCACGCGCAGCCCGATGCCCCGCGACCCGGACTCCTTCAGCGTCTCCACCTCGCCCATGCGCACCGTGGTCGAAAACTCATCGCCCTCGCGCACGCTCACCTCGGCATCGCTCGCCCCGGCACGCAACGCGCGCGCCACCATCTCGGTGGCGAGTTCCTGCAACGTACTCGAAATCGCCGCGTTGCTCATCGTCCCGTCCCGCCCACCGTCATCCGGTCCAGCTTCACGGTCGGCATGCCCACGCCTACCGGAACGCTCTGCCCGTCCTTGCCGCAGGTGCCCACGCCCTCATCGAGCGCCAGATCGTGCCCCACCATCGAGACATACTTCAGCGCCTCCGGCCCGTTGCCGATCAGCGTCGCATCGCGCACCGGAGCCGTCACCTTGCCATCCTCAATCAGGTACGCCTCGCTCGCCGAGAAGACAAACTTGCCCGTCGTAATGTCCACTGACCCGCCGCCAAAGTTCACCGCATACAGCCCGCGCTTCACACTGCGCAAAATGTCTTCCGGAGCGTCCTCGCCCGCCAGCATATAGGTGTTCGTCATGCGCGGCATGGGAATCTGCTGGTAGCTCTCACGCCGTCCGTTGCCCGTGTGCGGCATCTTCATGAGCCGGGCCGAGAGCTTGTCGCTCATGTAGCCCTTCAGAATGCCGTTCTCAATCAGCACCGTTTCCTGCGTGGCCGAGCCTTCATCGTCCACATTCAATGATCCGCGCCGGTTCTTGAGGGTGCCGTTGTCCACCACGGTGACCTTTTCGCTCGCTACAGGACGCCCGATCAGCCCCGCAAACGCCGAGGTCTTCTTGCGGTTAAAGTCCGCCTCCAGGCCATGCCCCACCGCCTCATGCAGCAGCACGCCCGGCCATCCCGGGCCCAGCACTACTTCCATCTCGCCCGCCGGAGCCGCTACCGCGCCCAGTTGCAGCAGCGCCGTCCGCGCGGCCTCGCGCGCAAAGTGCTCGGGCGTCTTTTCCGTCTCGAAGTAGTCGATCTCCACGCGCCCGCCGCCGCCCGAGGTGCCCTGCGCCGTGCGCTCGTCATTCTTCGCCAGCACAAAGACGTTCATGCGCGCCAGCGGCTGCGTGTCGCTGGCAAAGGTGCCGTCCGAGGCCGCAATCAGAATCCGCCGTAGCTCATCGGCATAGCTGGCCCGCACCTGCGTGATGCGCGAGTCATAACCCCGCGCCACCTTGTCGGCGCGGTGCAGCAGGTTGAGCTTCGCCGTAATGTCGATGTCGGCTTCCGCCCCCGGCACGGGATACAGGCTCGGGGTCCGCGTTTCTGTGAAGCCCTGCACCGGCTGCTTCGCCGGGCCGCTGGCAATCAGCGCCGCCGTGCGCGCCGCGCGCAGCAGCCGGTCAGCCGAAAGATCATCGGTATACGCATAGCCGGTGCGCTCGCCGCTCAGCACGCGAATGCCGCATCCTGCACTCACCCCATGGCTCGCCGTCTTCACAATCGACTCGTCCAGCCCAATCGACGAGGCCGTCACCGACTCAAAATACAGGTCCGCATAATCGCCGCCCGCTGACAGCGCCTCGCCCAGACAGCGCTCCAGCAGCCGCTCGGTGATGCCAAATTTCTCAAAGAAATACTGCTTGTGATCCATCGTCTGTTCACTCCTGGCTCACCTTTTGGATGTCCGAAGCCTGCCCCGCGGTGCGCGCGCCGGTCATTCCGCATGCGAGCTTCCAGCTTCGCACATTCCGGTAAAATCCCGCCCTCCATCCCCGCCTGTGACGGCCCATCTTGCGCACTCTGCCCCACTTTGGGTACCTTGCTGCCCATGGCTACTCCCACAGTGGATTCCGCCCGTTTCCCGATCGGCCTGTTTGACCGTGCCGCCGCCAGCCTTGACCACAAGGCCGCCATCGCTATTCTGGCCGCTCTGCCTGAGAACATGCGCTCCGCCGTCTCCGGACTGAGCGACGCCCAGCTCGACACGCCTTACCGCGAGGGCGGCTGGACGCTGCGCCAGGTCGTGCATCACGTCGCCGACAGCCACGGCCAGGCTTATGCCCGCACCCGCATGGCCCTCACCGAGGACTGGCCCGTCATCAAGCCCTACCACGAGGCACTGTGGGCCGAGCTAAGCGACGCCCGCACCGCACCGGTCGAGCTGTCGCTCGAACTGCTCGCCTCGCTGCATGCCCGCTGGGTACTGCTGCTCCAAAGCCTCACGCCCGAACAGTGGGAGCGCGGCTATGACCACCCCGAAAGCGGCCGCCACACGCTCACGCAGGTGGTCGCGCTCTATGACTGGCACTCCCGCCACCACCTCGCGCACATCACCTCGCTGCGCGAGCGCATGGGCTGGTAGGGACACGCCCGTCCAGGCAGGCGCGCCTTCGGCGCAAGCTTTGCCCTTACCGCGGAGAAAAAGCCGCGCCGCAGAACCGGGAAAATCGGGAGCGGATCGGCAGTGGTACACTTGTGTACACATCGGTACGCAGGAGCGGGCATGGACACTCAGAAGGTAGGCATAAGGGAGTTTCGCGACAAACTGGCCACGTACCTTCTTGAATCCGAGACGCCGGTGGCGATCACTCGCCATGGCGATACCGTGGGCTACTACATTCCGGCTCGCCGCCGGCGCAGCGAGGCGGAACGGGAAGCTCTCAAGGAAGCTTTCGGACACTGGCAGCAAATCCTCAAGGCGGAAGGCATTTCAGAGGACGAGGTGCTGGCAGACTTCAAGACCTGGCGCGCGAAGCAGAAGCAGTGACGGAACGCAAGCGTCTCGTGCTGGACGCGAATATTCTTCTTCGTGCGGCGTTTGGTGTCAGGGTGCGCAGCCTGCTCGAAGCCTATGAAGATGCGGTCCTCTTCTTCACTCCTGATGTATGCATCTCCGATGCGCGCCAATATATCCCTGCTCTGGCCTCAAAGCGGGGCATTGACGCCGCGCCGGGACTCGCTGTGCTGGACAAGTTGGCGGGTCTCATTGAAATCGTGAACAGTAGCCTCTATGAGAGCTATGAGACGCAGGCCCGCGAACGGATGCAATCCCGGGACATGGAAGATTGGCCCATCGTGGCGGCTTCTCTACTGCTGCAATGCCCCATTTGGACAGAGGATCAGGATTTCTTCGGCAGCGGCGTCTCCATCTGGACCACGAGGACCATCGAAGTCTACTTGCGCGATGCCTGAGGACCGGTAGCGGCGGCTTGTATCTCCGCACACGCCGGGATGCCTGTCAGTATCTGCCGCCGCTCACCCCTCCGCCTTCCACTCCAGCTCCTCAAACCGCCCCACCTTGTACACCGCAATCGACACCATCCAGCTCAGCGCAAACAGCGCAATGATGCCGTAGCCGAGCAGGCCAAAGTGGTTGTTCAGCCCATCGATGCCGCGCCAGAACCATCCCCGCAGATGCAACTGCCCGCCCAGCAGCCCCAGCGCCTCAATGCCGCCCACACCCACGGCCACCGCGACTGAAACCGCCGTGATCGTCAGGTTGTAGTAGAGCTTCCTGATCGGCTTCACATACGCCCAGCCATACGCGCCCAGCATCAGCACGTTGTCCGTCGTGTCCACCAGCGACATGCCGGCGGCAAAAAGGGCAGGGAAGACGAGAATCGAGCGCAGCGGCAGCCCGTGTGAAGCCTCGGCTGCGGAGATGCCCAGCAGGCCAATCTCCGTCGCCGTGTCAAAGCCCAGCCCAAACAGCACGCCCAGCGGATACATGTGCCAGCTCGCGCGAATCCTGCCAAAAATGGGCCGGAAGATGCGCGCCAGAAAGCCGCGCCCGGCCAGCAGCAGGCTCAGGTCTTCCTCCACATACGGCTCGCCGCGCCGCACCTTCTGGAAGCTCGCGTAGACCCCCCGCAGCACCATCCAGTTGGCGGCGGCAATGCCCAGCAGAAAAAGCGACGAGACCAGCGTGCCCACCACGCTGCCCACACTCTCGATCCAGCGCATGTGCGCGGCCACATGGCTCTGCACGCCAAGCGTCACCGCCGCCATCGCGAGCGAGCCGGTCACCACGACCGTTGAATGCCCCAGTGAAAAGAGCAGCCCCACGCCCACCGGGCGCTGGCCCTCCTGCATCAGCTTGCGGGTTACGTTGTCGATGGCCGCAATGTGGTCCGCATCCACGGCATGCCGCAGGCCAAAGCTGTAAGCCAGAAACGCGGTGCCCAGCAGCAGCGGATAGCGATGAAACGCCGCCACCGCCCATAGCCATGCCGCGCCATTGAAGAGCACGAGCAGCGCATACACCAAAGCAATGCGGCCCCGCACGGGGGCCGCATCGCTTTGCTTTCGTTCGGGATGCATGTTCGGTCTCATCGCGTGTGCTTCTATTCCAGCACATCCCCGGCCAGACCGATATGCGGCCACAGCCTACGCGCTGGGCTGGGCGTTGCGACGGGGACGCCGGTTGGCCTGCAGCACCTTCTTGCGCAGGCGCAGCGACTTCGGCGTCACTTCCACCATCTCGTCGTCCGCGATGAACTCGATCGAGTTCTCCAGGTTCAAGAGGCGCGGTGGCGTCAGGCGCACGGCGTCATCGGCCGACGACGCGCGCATGTTCGTCAGCTTCTTCTCGCGCACCACGTTCACATCCAGATCGTTGTCGCGCGAGTGCTCGCCGATAATCATGCCCTCGTAGACTTCCACACCTGCCGGAAGAAACAGGATGCCGCGATCCTGCAGGCCATCGAGCGCATAAGCCGTCGTGGTGCCCGCGCGGTCGGCAATCAGCGCGCCCGTGGGCCGCTGCGGAATCTCGCCCTGGTACGGCATGTATCCATCAAAGATGGAGTTCATCACGATGGTGCCGCGCGTCTCCGTCAGCATTTCGCTGCGCAGCCCGATCAAGCCGCGCGAGGGAACCTTGAACTCCATGCGCACACGGCCCGAGCCGTGATTGTGCATCTTGGCCATCTCGCCCTTGCGGGGCCCGAGGCGCTCGATGACCGTGCCGACGAAGTTTTCCGGCACGTCGATGGTCAGGTACTCGACCGGCTCCATGGTCTTGCCGTCCACCACGCGGGTGACGATCTCAGGCCGGCCCACCATCAGCTCAAAGCCTTCGCGGCGCATCATCTCGATCAGAATGGCGAGCTGCAGTTCACCGCGGCCCAGCACCTTGAACGAGTCAGGGCTGTCGGTCTCTTCCACGCGGATCGAAACGTTCGTCAGCAGTTCCTTGTCGAGCCGCTCGCGCAGGTTGCGCGAGGTCACGTACTGGCCCTCGCGGCCGGCCATGGGCGAGTTGTTCACCATGAACTGCATCGCGATGGTCGGCTCGTCGATCACAATCAGCGGCAGCGGCGCGGGATTTTCAATGCCCGTGATCGTCTCGCCGATCGTGATGCCTTCCACACCGGCCACGGCCACAATATCGCCAATCTCGGTGCTTTCGATGTCCACGCGCTTGAGGCCGCTGAAGCTGAAGAGCTTGGTGATCTTCGTCTTCTGCAGCGAGCCGTCACGCTTTGAAATGAATACCTCGTCGCCGGTCTTGAGCGTGCCGTTGAAGACGCGCGCCACGGCCAGGCGGCCTAGGTAGTCCGAGTAATCGAGGTTCGTCACCAGCACCTGCAGCGCGCCGTTGGCGTCGCCGGTGGCCGGAGGAATGGTCGTCACAATCTGCTCAAAGAGCGGCTGCAGGTCGGTGCCGGGCGTCGCCGCATCCGTGCTGGCCGTGCCCTGCTTGCCGTTCGTGTACAGCACCGGGAACTCAAGCTGATCCTCGGTCGCGTCCAGATCGATGAACAGGTCATAGACCTCGTTCAGCACTTCCTGCGGACGCGCATCGGGGCGGTCAATCTTGTTGATGACCAGGATTACCGGCAGCCGTCCGGCCAGTGCCTTTGAGAGCACGTAACGGGTCTGCGGCAGTGGGCCTTCCGAGGCATCCACCAGCAGCATCACGCCGTCCACCATCTTCAGTGCGCGTTCCACTTCACCGCCAAAGTCGGCGTGGCCCGGGGTGTCGACAATGTTGACCTTGTCGCCCTTGTACTGAATGGCCGTGTTCTTGGCCAGAATCGTAATGCCGCGTTCGCGTTCGAGGTCGTTCGAGTCCATCACGCGGTCGGTGACGGCTTCATTGGCGCGGAACGTTCCGGCCTGGCGCAGCATGGCGTCGACGAGAGTGGTCTTGCCGTGGTCGACGTGGGCGATGATGGCGATGTTGCGTATCGTGCTCACAGGCACAGATTTCCTTCCTGGTTACAGTTCTTCTTCTGTTGGATATCTCTGAAATTGCGCGCAATGCGCCGGCTGTTGCCAAAACTTCGGAGGGCTCACCTCCAGTTTAGCAATTTAGCGCGGAAAAAGGCCGGAATCGAGCGATTCCGGCCGAAAAGGATAGAGGAAGGAGAGACGCCTGAGGAGAAACCTGTCCCGGGCTCAGGCCCGGGGCGTGCGAAGCGGCGAAAGCCCTGCCGCGCCGCCGCGCTCACTGCCCAAAGCTGTCGCCGGCCGTGCGCTGCCCGGTGTTGCCGCCGAGGGACGCGAGCTCAGCGAGGCGCTCATGCTGCGCAATCCGGCGGCGGTATGGGCGGCCTGCTGGTGCATGGTCACAATCACCACTGCGGCTGGCGTTTTGCCCGCGCACTGGTAGGCATGCGGCGTGCTGGCATCAAAGTACACACCGTCGCCGCCCTCCAGCACGTGGAGCTTCTCGCCATGCTTGATCTCCAGCTCGCCGCTGATCACGTAAAGAAATTCAAACCCCGGATGCACGTGCGCCCGCACTTCGGTGCCTTTCTTCAGCGGCACAAACTCGGCATAGTAGGGGTCAAGCATGCGATCGGGAACCATGTAGCCGAGGCTCTCGAAGAAATAGGTCGGGTCATCGACGCCGGTCTGCGGCAGGCGAACGCGCTCTTTCTTCTTATGAACACGGAAGAGCGTGTGCGGTTCCGTTTCAAAGAAATAAGAGAGATCCTTGCTGAAGACCATGGCAATGCGCGCCAGGTTGCGCAGGGTGGGCACCACGCGGCCCGTCTCAAGCTGAGAAAGGAAGCTGGCAGAAAGCCCCGTATGACGGCCCAGTTCCACCAATCCCATCGACTTCTTCAGGCGCAGCCGCTTGATGCGCTCGCCGATTCTCTTTTCCGAAATGAACGCCTCGGCGCTCGCCGGATCAATCTCCACACTCGGGATGCCTTCCTTCTCCTCGGTAGCCATGCTTGTTTCCCCTTTTCGCATCTGATCTCTGTTATTTATTATCCGCCTGCTTCAAATGTTTTTGATGTGGCAAAACGGGCGGCGTAACCCCATGCCTTTCATACGCATAAATTCCCGGAAAGGATTGTCGATCTTATGAAACCGCAAGTGCTTTTGAGTGGTGCCTCCGGCCTGATTGGAACTGCTTTGCGCGAGATTCTGGCCCAGGAAGGGTATGGCTGCAAGCAACTGGTGCGGCGTCCGGCGCGCACTTCAGAAGAGTTGGAATGGAACCCCCAGTCTGGAAAGACGCCTGATTGTAACCGCCTGAGTGGAACAGAGATAGCCATTCATCTCTCCGGCGCCAACATCTCTTCCACGCGATGGACAGACGCCCGAAAGCGCGTTCTGGTCCAGAGCCGCGTCGAGCCCGTGCGTGCCCTGGCCGCCGCGCTTTGCCAGACCGAGCCCCGGCCCAAAGTGCTGGTGTGCGCCTCCGCTATCGGCATCTATGGCGAGCGCGGCGATGAGGTGGTCGATGAAAACTCCGCTCCGGGCCAGGGATTTCTGCCCGAAACCTGCCTCGCCTGGGAGGCGGCCGCCGCTGAGGCCGCTGCTTGCGGCATTCGCGTGGTCTCGGCGCGCTTCGGCATTGTGCTCTCGCCCAGAGGCGGAGCGCTGGCCAAAATGCTGCCGCTCTTTCGCCTGGGCCTCGGCGGCCCGCTCGGCAATGGCCGCGAATGGATGAGCTGGATCAGCCTCGAAGACACCGCCCGCGCCCTCATCTTCCTGGGCCAGCGCGCCATCGACGACCCCTCCGCTCCGCTCGTGGAAGCCGTCAATGTGGTCGCCCCCAACCCGGTGCGCAACGCCGATTTCACCCGCCAGTTGGGCCATGTGCTCCACCGTCCGGCGATTCTTCCGGCTCCGGCCTTTGCCCTGCGGCTGGTCTTTGGCGAAATGGCCGATCAGGCGCTGCTTGCCTCCACGCGCGTCGCCCCCACCCGCTTGCAGCAAAACGGCTTCGAGTTTCACCACCCCGCGCTGGCTGAGGCGCTGCGCCACGAACTCCAATAGCCCCCGCCCTCTGTTACGCTGGGCAGAAGATGACCACGGCAGGGGCAAAATCCGCAGCAGCAGGCAAGCGTGCGCTCAGCGCCGCCGCCCTGCTGCTGGCCGGCCTGCTCACCGGTTGCGCGCTGGAAGCCGCTCCGTCGCCGCCCAGCCTCAAAATTCCCACTCCCGTCAAAGACCTCACCGCCACGCGCGCCGGCGCCGCCGTCACCCTGCATTGGACCATGCCCAAACGCACCACCGACAAGGCGCTGCTCAAAGGGCCGCAGCCCGTCGTGGTCTGCCGGGCCGTGCTTCCGATTGCTGCAGATGCCGCTTGCCAGCCTATTGCCACGCTGCATTTCGCACCCGGCCAGGCCGCAAGTTGGACCCACACGCTGCCGCCCGCCTTGCTCGCGGGCACGCCGCGGTTGCTGGCCTACTCCGTCGAGCTGTACAGCCCGTGGAAGAAGACCGCCGGGCTATCGAACGCCGCCAATGTGGTCGCCGGAGCGCCCCCGCCACCCGTCGGCCCGCTGCGCCTCACCACCCGCAAAGACGGCATCGTCATGCACTGGCAGCCGGCCTCGGCCGAGCCGCACATGGTCATGCGCATTCACCGCACGCTGGTCGCGCCGCCGCATGCGAAGCAGCCCCATGCCTCAGCCGGAAACATGGCCGGGGAGGGCCCCGCGCCCGAGCAGGTGCTGGAGATCAGCCTCAGCCGCCGCGACCCCGGCCAGGCCATTGACCGCGACGCCGCGCTCAACCACACCTACACCTATGTGCTGCAGCGCGTGCTTGAGCTCAAAGTGAACGGAGCCGCCGCCGAGCTGCCCGGCGCGCCTAGCCAGCCCGTCACCGTGAACGCAAAAAACCTCTTCGCGCCCGCCGTGCCACGCGACCTTGAGGCCGTGGCCGACGCTGCCGCGCGGGCCATTGATCTCTCCTGGCAGCCCAGCCCCGAGAGCGACGTGACCGGCTACGCCGTCTATCGCCGCATCGCCGGTTCGGGCGGCGCATGGCAGCGCATCTCGCCCGCGAAGCCGCTGCTGGCCGCGCCCGCCTGGCATGACGCCGAGGCCGAGCCAGGCGTCACTTATGAATACGCCGTCACCGCCATCAGCAGCAATGGACTCGCCAGCCCGCGTTCAGCCCCGGTGAGCGAAGCTCTGCCCGCTCAGTAGGCTCAGCTCTCTCCCATCTGGACAGTTTTCATCTGCGTTCAACGCCCGTCGCCCCATCCCGCAGGCTCCTGTTACATTTGCAGTGCCCACTGTAAGGAGCATCATGCAATACTGCCGTTTTCTTTCTGTCGTTGGACCCCAGTACGGAGCCGTCATCCCACGCGACGGCGAGCTCTGGATCGAGCATCTGCTGCCTGCCTTTGAAGAGGACCCCACCGCGCAGCCCAACGCCGCCTCGTTTTTACCCATGCCGCTGGCCCACGCCCGGCTGCTTGCGCCTGTGGCGCCGCCCAAAATCGTTTGCATCGGGCGCAACTACCGCGACCACGCCGCCGAGCTGGGCAATGACGTGCCCAAAGAGCCGCTGCTCTTTTTGAAGGCGCCTTCCTCGGTCATCGGCCCCGGTGAGGCCATTCAGATTCCGCCCCAATCCAAACGCGTCGATTTTGAGGGTGAGTTGGCCATCGTGATCGGCCACCGAGCCAGCAAAATCGGCCCCGACGAGGACGTGCGCAGCTACATTCGCGGCTACACCATCGTCAACGACGTCACCGCGCGCGACCTGCAAAAGTCTGACGGACAGTGGTCGCGGGCCAAGGGCTTTGACACCTTCTGCCCGGCCGGCCCCATCGTGACCAGCGACATTGACCCCGTCGCCGGCCCCGGCCTCAGCGTCACCACCACCCTCAATGGCGAAACGAAGCAGCACGGCCACACCCGCGACCTCATCTTTCCCATTCCCGAGCTGCTGCGCTACATCACCGCCGCCATGACGCTCGTGCCCGGCGATGTCATTCCCACCGGCACGCCCGCCGGGGTCGCGCCCATGCAAGCCGGTGATATGGTGCAGGTTACGGTCGAGGGCATTGGATCGCTCAAAAATCCGGTCGCCTGAGCAGGGTGGTTGCATCTTAATAATTAGAGTTGCCGCCTGCCCCGCGCGGCTTGTCCGGTTCAGATTCAGGAATGCCCGGCGCGGTGCCAGCCCTCAGGGGCATTGGCCCCGGCCATTCCGGCTACAATGAAAAGTGAACTCCCAAGGAGGAATGATGTCTCAGTCTCTGCTCGCTCAGCTCCGTAAAATGACGACCGTAGTCGCCGACACGGGCGATATCCAGGCGATTGAAAAGGTTCGCCCGCAGGATGCGACGACCAACCCTTCGCTGATCACCGCCGCCGCCGGCATGCCGGCCTACCAGAAGATTGTGGACGACACGCTGCTCGACGCCAAGAAGCAGCTTGGCGACAGCGCCCCGTCTGACAAGGTGGCCAAGCTGGCCTTTGAGAATCTGGCCGTCGCCTTTGGCAAGCAGATTCTGGCCATCATCCCCGGCCGCGTCTCGACGGAAGTGGATGCGCGCCTGTCCTACGACACCGAAGCCACCATCAAGCAGGCCCACGCCATCATTGAGAAGTATCAGAAGCAGGGCATTGGCCGCGAGCGCGTGCTCATCAAGATTGCCTCCACCTGGGAGGGCATTCGCGCCGCCGAGCAGTTGGAGAAGGAAGGCATTCACTGCAACCTGACGCTGCTCTTTGGCATGCATCAGGCCGTGGCCTGCGCTGAGGCTGGCGTCACGCTCATCTCGCCCTTCGTGGGCCGCATTCTTGACTGGTACAAGAAAGACACCGGCAAGGACTACGTGGGCGCGGACGACCCCGGCGTGCAGTCCGTGACCCGCATCTACAACTATTTCAAAAAGTTCGGCTACAAGACCGTGGTCATGGGCGCGAGCTTCCGCAACACCGGCGAAATCATCGAGCTGGCCGGCTGCGACCTGCTCACCATCTCGCCCAAGCTGCTTGAGGAGCTGGACGCCAAGGAAGCCGAACTGCCCCGCAAGCTCGACGCCGAAAAGGCGAAGGGCATGGAGATCGAGCGCATCACGGTCGACAAGGCCACCTTCGACAAGATGCACGCCGAAGACCGCATGGCCCACGACAAGCTGAAGGAAGGCATCGAAGGCTTCTCCGAAGCTCTCGAAAACCTCGAAAAGCTGCTCGCCAAGCGCCTCGAAGAACTGAGCGCCGAGCCCGTAGGCGCGAAGTAGTTTTCTTACTCACGGAAAGACAAAAGGCCAGCCCGTCGGGCTGGCCTTTTGCTGTGGGCTTGAAGAACATGCAGGATATGGGGGGATCATATCTAGACTCCTTCAGACACACTCTTGTCTACAATCTCGCGTATTGTTCGAACGCGTTCTTCATCCAGGTGTCCGCAGAACCATAAGGTCTTCCTGTCGAGGAGGATCTGAAGCGGCGCGGAAGCTTCTTCGCCTAAGTCGCCTATTGAAGTTCCAGCGCGGCGTAACTCCCATGCGATTAGATCAGCCATCTGCAGCTGCACATAGCTCTCGTCATCTGCAGTGGTACATGATCCCATATATTCAGCAGCGTTCGGATTTCGAGACTTCAATTCTGGATATGACCGCGTAAGGATGTCACGATATCGGCCATTCTCGTCGCAGACGAAAGATACAGAATCAGTAGCACCTGCGCGTCGCAGGTCCATCGCGATTCTGACAAAGATCGTCTGGTACATGAGCATGTAAGGGTTCTCTTTATATTGCTTGTGAAGGCTCGAGCCGTTTAGGTGTTCCCTCACGACCGTTTGATCCGTGATAAGCCCGCTTGCGATCAGTCCGGAATCAGCAATTGCCATTGCAAACTCCGCTCGTACTTCAGGCTTCCCCTGTAGCTTGGAAGCCTTGAAGGATCGCAACTTGTGCTTACAAAGCAATTCGCGCCAGAGCGTCTCTCCCCTGAGCGCTGACCAGCCATTCCCAAACACGGCGGCTACTGCGAAGCGACCTAGGTTCTTATCGTCAAAGCTCTCATCGATAAATGCAGTGAACATAAGTGTTCAAATCCCTATAAAAGATAATAGGTCTTGGCTTCAAGGTGCCACTGAATGGCGCCATGTTGTGGTACGCGCGGCTTTTATGTTCAAGCTGATGCCACAGATCTCAAGCGGTGATCAACCGACTGGGTTGCGTCATTCTGAGGCCGAAGGCCGAAGAATCCCGGCGATGATTCGGGTGCCAATGCTGATCGGAGTTTCTCCCAGAATGGTGGGAGAAACCTTGCGGTGCAACGGGCGTTCGAGGCATCGCCGGGATTCTTCCCTCGCATGTTTCGACCGGAGGGTCGAAACATGCGGCTCAGAATGACGCGGGCGAGAGCTGTTCCTCAAGCGAGATGGTTGCTGGTCAAAGAGAACAGCTAACTCACTCAACGCTCAGACGAGCAACACCCACACAAGCCAAACCCGGCTTGTATGGGGCACCCACCCGATTGCCACTTACTCCCCGGTTTCCACCCCTCCGCGCCCGCCATTTATAATCGCCATTGCCTTATGGATACTCCGAACCCCATTCTGGACGGCAAGCAGACCCTGGACATCCGGGAGATCATGTCGATCCTGCCGCATCGTTATCCGTTTCTGCTGATTGACCGCGTCGTCGAAATCGAGCGCAAGAAGCGGATTGTCGCCATCAAGAACGTCACCATGAATGAGCCCTTCTTTCAGGGCCATTTCCCCGGCATGCCGGTCATGCCCGGCGTCATGGTCATTGAGGCCATCGCCCAGGCCGGCGGCACGCTGCTCATGCCCGAGGTGCCCGATCGCGACAAGCTGCTCATCATGTTCACCAGCATCGAGCGCGCCAAGTTCCGCCGCCCGGTCGTGCCCGGTGACCAGCTCCGCATTGAGATCGACGTGCTCAACTGGAAGCCTCGCCGCGCCAAGATGGAAGGCCGCGCCCTGGTGGACGGCAAGCTCGCCTGCGAAGCCACGGTGATGTGCCAGCTCGTGCCCCGGCCCGACGCACAAGCCACCGAAGCCGCTCCGGCCGCTGAGTCCGGCGCTGAATCCGCTCCCGCGCAGGAAGCCATCTCCACAGTGAGCGCCGAGTGAGCATTCATCCCACGGCCATCGTGGCCGAAGGCGCGGTGGTTCCCGCCTCCTGCACGGTCGGGCCTTACTGCACCATCGGCCCCAATGTCGTGCTGGGCGAGGACTGCGAGCTGGCCTCACATGTAGTGCTCGACGGCCACCTCACGGCGGGCGCGCGCAACAAGTTCTACAGCTTCGCCTGTGTCGGCATCGCCCCGCAGGACCTCAAGTACAAGGGCGAGCCCACCGCCGTCGTGCTCGGCGATGACAACACCATTCGCGAGTACGTCACCATCTCGCGCGGTACTCCCGGCGGCGGCGGCGCCACGCGCGTCGGCTCGGGATGCCTCATCATGGCCTACACGCACATCGGCCATGACAGCGTGATTGGCAACGGATGCATTCTGGCCAACGCCGCCACGCTGGCCGGCCACGTCATCGTAGAGGACTACGCCACCGTCGGCGCGCTCTGCCCCGTGCATCAGTTCTGCCGCATCGGGCGCTACGCCTACATTGGCGGCGGCACCACCATCACGCAGGACGTGCTGCCCTTTTCCCTGACCTCAGCCAAACGCGAAACGCACGCCTACGGCCTCAACAAGGTGGGCCTTGAGCGGCGCGGCTTTGACCGCCCCCGGCTGCGCGCCATTCAGCACGCCTACCGCCTGCTGCTCGCCGCCAAAATGAACACCACGCAGGCCATCGCCAAACTGCGCGAAGAGGGCATCGCCACCGAAGACGTCGCCTACCTCGTCGAGTTCATCGAGCAGTCCGAGCGCGGCGTGCTCAAATAGATCGCATATGAGCAAACTGGGCCTCATCGCCGGCAACGGGCGCTTTCCGTTTCTGCTGCTGGAGGCCGCGCGCGCCAGCGGCCTCGAAGTCGTCGTGGCCGCCATCAAAGAAGAGACCGACCCGGAGATGAACGACCGCGCCGCCGCCGACCCCGGCCTGCGCGTCTACTGGCTCTCGCTGGGCGAGCTGTCCAAGCTGATCGATACCTTTCACAAAGAGGGCGTCACCCGCGCCGTCATGGCCGGGCAGGTGCGCCATAAGCAGATCTTCTCCAGCATTCGCCCTGACTGGCGTCTCGCCAAGCTGCTCATGAGCCTGCGCACGCGCAATACAGACATGCTGCTGGGCGCGGTCGCGAAGGTTCTCGGCGACGAAGGCATCGAGCTCATCTCTTCGACGACTTACCTGGAACCAATGTTGGTTGAGCCGGGCGTGCTGACCGAGCGCGCGCCCGAGGAAGACGAGCAGCGTGACATCGCCTACGGCCGCGAAGTCGCCAAAGGCATCGCCGGATACGATCTCGGCCAGACCGTCGTCGTTGCCGCGCAGGCCTGCGTCGCGGTCGAAGCCATGGAAGGCACCGATGCCACCATCGAACGCGCCGGTGCGCTTATGCGCACGCTTGACGATGAAGCCTCCACGCTCTCGCACCGCCTCACCGTCGTGAAAGTGGCGAAGCCGAAACAGGACATGCGCTTTGACGTGCCCGTGATCGGCCTGCGCACCATCGAGACGATGATCGCTGCCGGAGCCACCTGTTTGGCCATAGAGGCAAAACGCACCCTCATTTTTGACAGGGATGGAGTACTCGCCCGCGCCAACGCTGCGCGCATTGCGATCATCGCCGCCGAATAACGATAATGAGTCGGGCGGAAGCCCACGGTCCGCCAATGCGGGCCACTTTTCGGAGCAAACCTCATGAGCAGATTCTGGATCATCGTACTCGTGGCCGTCGTGGTGACGTTGGGCGGCCTGGCGTTGCGCAGCTTCGCAGCGAAAGTCCCAGGCATGCCGCGGGTGGGCCAGATGGCTCCCGGCTTCACGCTGCCCAATCAGGAGGGCCAGCCGGTCAGCCTCGACAGCCAGCGCGGCAAATGGGTGGTGCTCTACTTCTACCCCAAGGACATGACGCCCGGCTGCAGCATCGAAGCCCACAACTTTCAGCGCGACATCGAGAAGTATCACGCCGCCAATGCCCTCATTCTGGGCGTGAGCCTCGACACCGTGAAGAGCCACAAAAAGTTCTGCACCAAAGATGGACTCGGCTTCACCCTGTTGAGCGATCACCAGGCGCAGGTTTCAAAAGACTACGGCGTGCTCGGCAATTACATGGGCTTCAAGATCGATCATCGCGTGACGTTCCTCATCAATCCAGAAGGCCGCGTCGTGAAGGTGTGGCCCAAAGTCAGCCCCAGCGGCCACAGCGAAGAGGTGCTCGCGGAGCTGGCAGCGCAGCAGAAGGCCTGAGAGCAACCCGTTTTCAAGACGCAAAAAAGCCCGGCGCATTGCCGGGCTCTTTTGCTTGCCTCGTCTTACTTATGTTGCCGTAGAACTACTTCTTCTTCGGAGCAGCTTTCTTGGCGGCCTTCTTGGCAGGCGCCTTCTTCGCTGCAGCTTTCTTGGCGGGAGCCTTCTTGGCTGCCGTCTTCTTGGCTGCGACCTTCTTAGCAGGAGCCTTCTTGGCGGCTGCCTTCTTGGCCGGAGCCTTCTTCACTGCGGTTTTCTTTGCTGCGGCCTTCTTGGCCGGAGCCTTCTTTGCGGTCTTGACTGCCAAAGGAGTACCTCGTTTGGTTGATTTTTTACTGCTTGTGCTCTTCGCAGCCGAGGATTTCTTCTTGACTGCTCCGCCGCTGAGAGCACGCTTACTGCTGGACTTCGCGGCAGACTTGGTGGCGGGTTTCTTGGCAGCGGCTTTCTTCACTGCCTTCTTCGCCGAAACTTTCTTCGCGGCCTTTTTGGCCGGGGTCTTCTTCGCAGCTTTCTTTGCCGGTGCCTTCTTTGCTGCTGCCTTCTTCGCCGGCTTCTTTACCGCCGGAGCCTTGGGGGCTTCTTCCGCGACTAGCAGAAACTCCGCTTCGGTCACGGCAGCAGCCGGAACTGCGAACTCCTGCTCGTCCTCCAGCGCGTCGTCTTGATCATCGTCAGAAGAAACCGAGATCGTTACCTCTTCTTCTTCTTCCTCGTCGTCAAAGCTGTTCTCAAGCTCTTCAGCCGAGTCATCTGGTTCCGGCTCGAAGTCGCTGTCGTGATATGCGTACAATCTGCGATGATCCTGCATCGGTGTGCCCTCCAGGGCTTCGCTTCTTTGCCTTCGCTTCAGATTTGCAATCCGCTGCCGCACAAAAGCCCTGCGGCGCGGATTATAGCAACAGCATGCATCGCCCCGCCATAACGCGCAAGTATTTCGTGATGTACTTCTGAAGCTTTGGTGATCTTTATCACACGCGGTGGCAAAATTTTTATCTCAAAGCAGAGACGCGCAGCGAGTGTCCGGCGCGAATCTCATTTCCGCGCAGATGATTCCAGTGGCGCAGGTCAGTGATCGAAACATGAAAGCGCGCGGCAATGCCGCCAATGGTGTCGCCGCGCCGCACGCGGTAATAGCGTGGGTGTGACGCAGCGGCATGCGCAGCGTGCGCGGCTTCATGAGACGCGCGCGCGCTGTGGTGCGCCGGCGGATCGGCCAGTGTCGCGTGCTCATGCGGAGGCGAGACACGCAGAGAATGTCCGGCCGCAATTTCGTTGCCGTGCAGATGATTCCAGCGGCGCAGGTCTTCAATCGAAACGTGGTAGTGGTCCGCAATGCCGCCCAGCGTTTCTCCCCGGCCGATGCGATGGTACTCCGTGCCTCCGCGCGCATAGGTGGTGTTGCGCATCTCAGCCCGCACCGGCGTGGAAACATGCAGAAGCTGGCCCGCACGCAAAAAACTGCTGCGCAGATGGTTCCAGCGCCGCAGACTGAGAACAGAGACGCCATAGCGATCCGCAATCGAGACCAGCGTATCGCCGCGCCGCACGCGGTAGACCAGCGTGCGAAGCAGGCTCGGCTGGGAGGGCCGCGCCACCGGAATCACGACCGCGTCGCGCTGCGCCAGATCAGTGGGTGCATCAATCTGGTTGACCGACGCCAGCTCATCCTCTGAGACGTGATACTCGTGCGCGATGGACGCCAGTGTGTCCGTGGGCTGCACCTGATGAAAGCGCCAGTCTCGCCGGTCGTCGGGCGGAATGAGCGCAATGTCCTGCTCAAAGCTGCTCTTGGTGCCCGAAGGAATGCGCAGAGTAAAGGCCTCATCCGGCGGAGTCGCGCCGCGCAGCAGGCTTGGGTTGAGTGCCTCCAGTTGATCCACTGAGGCGCCCGTGATGTCGGCGACGAGATGCAGGTTGATCTCCGTGTGCGTCTCCACCGTGTCATACGTCAGTGGAGGATCAAGGCTCAGGTCGTTGAGCCCATACTGGCCCGGGTGCTTGGCCATGAAGGTGACGGCCAGAATAATCGGAACGTAGTTCTTCGTTTCCGCCGGCAGATTGTTGAGCTTGTAGAGCTGCCAGAAGTCGGCATAGCCGGTACGCTCGACCGCGCGTTGCACATTGCCCGCGCCCCAGTCGTAGGCGGCCATGGCCAGGTACCAATCACCCAACTGGTCATAGTCCGCCTTGATGAGCCGGCAGTAGGCTTCGGTAGCAAGCACCGGATCAAAGCGCTGATCCACCCACGCGTTATGCAGCAGGCCATAATTGCCGTAAGGCATGAACTGCCACATGCCGCCCGCGCCCGACGAGCGATTCATCGCAGTTGGATTGAAGCCCGATTCCGCGACCGCCTGATAATAAAGATCCTGCGGCAGGCCGGCCTTCTTCAAGACGCCTTCGATCATCCCCTTGTAGCGGCCGCCGCGTTCGAGCGAGGCCACGATGGTGTCATGTCCGCGCTTCGTGTTTTCAAAAAAGTTGATGTAGCTGGCGACATAATCGTTCATCACCAGCGGCAGGTCAGACTGCGTGGTCTTGATCTCGGCCGCGGCCTGGGCTTCGAGCTTCGCGTTTACAGGAAACGTGACGTTGTTGGCCACATCTACCGGCGAGGGCTCTGATTCGGTGAGCCCGTTGCCTTGCTTGAGCGCATCCATTTCGAGCGTGTCCACGGAATCGACAATGCGGTCAAACTCGGCGCGCAGAGCAGCATCGGTCTTGAGATTGACGCCACAGGTCAGCAACTGATCCACGGCACGGTTAAAGTGCTGCCGCGCGGTGTCGAGGTTGCCCTGCTGGTAGGCATCAAGGCCGCTGTGGTACTGGTCCTCCACGCCTGCAATGATGCGCTGGTCGCGATCGCTCGGCGTGCTTTCCGCCGTGGCGGCCGCCGCAGTGTCATCAGGCGAGGCGGGCGCCGCCGTCGCCGGGGCCACCGCCCCGCGCGGCACGGTGTTGGCCGCCTGCTGTGAGGGACAACCCGTGAGTGTGAGCAAAATAGCCCCCGAAAGGGCTCCGGTGAGCAGGATTCTGGATACAGCCATGATCAAAAGACGAGAACTCCCCTTCATTGTAGGCCGCGAGCCTCAAAATGCCGATGGTAAGATCAGCTTTTAGGGAAGTTTCCCGCTTTGGCTCTTCTTCCCGCCCCCTTTTCTTCATGGACAGCAAGTACATTCGCAACTTTGCGATCATCGCGCATATCGACCACGGCAAATCCACGCTCTCTGACCGGCTGCTGGAGATGACCGGCTCGCTCACCGCCCGCGAAATGCAGGCCCAGGTACTTGACGCCATGGACCTGGAGCGGGAACGCGGCATCACCATCAAGGCCCATGCCGTGCGCATGCTCTACAAGGCCAAAGACGGCGAAACCTATCAGCTCAATCTGATCGATACGCCCGGCCACGTGGACTTCTCCTACGAGGTCTCGCGCTCGCTCGCCTCGTGCGAGGGCGCGCTGCTCATCGTCGATGCCTCGCAGGGTGTTGAAGCGCAGACGCTCGCCAACGCCTATCTCGCCATCAACAACGGGCTTGAGATCATTCCCGTCATCAACAAGATTGACCTGCCCAGCGCCGACATCACCCGCACGCAGGAGATGATTGAGCAGGCCGTCGGCCTCGATGCCACCGATGCCATCCCCGTCAGCGCCAAAACCGGCGTCGGCGTGCCCGACGTACTTGAGGCCATCGTCAAGCGGCTGCCGCCGCCCACCGGCGACCCCAATGCGCCATTGCAGGCGCTCATCTTTGATTCCTGGTTCGACGCCTATCGCGGCGTCATCGTGCTCGCTCGCGTCATGAACGGCACGCTCCGCAAGGGCATGCGCATCCGGCTCATGTCCAACGGCAAGGTCTTTGATGTGGAGTCGATGGGCGTGCTCACGCCCAAGCCGATGGAGATCGGTGAACTCTCCGCCGGCGAAGTCGGATTTTTTGTCGCGACCATCAAGACTGTCTCCGACACCAAGATCGGCGACACCGTCACCGAGGACGCTCGCCCGGCCGCCGAGCCGCTCGCCGGTTTTGAAGACATCAAGTCGATGGTCTTCGCCGGCATCTACACCGTTGATTCGCACGAGCATACGCTCTTGCGCGACGCGCTCGAAAAGCTGCGCCTCAATGATTCGTCGTTCTTCTTTGAGCCGGAGAGTTCCGTGGCGCTCGGCTTCGGCTTCCGCTGCGGCTTTCTCGGCCTGCTGCACATGGAGATCATCCAGGAGCGTCTGGAGCGCGAATTCGACCTCGACCTGATCACCACTGCGCCCGGCGTGCGCTACAAGATCACCATGACCGATGGCAGCACGCTTGAGGTCGACAATCCCTCCCGCTGGCCCGACCCCAGCGAAATCGAGCAGGTCGAAGAGCCCGTGATTCGGGCTACCATCCTCACCAATGAGGAGTACGTCGGTGGCATCCTCAAGCTGGTCGAAGAGAAGCGCGGCCGCCAGCAAAACTTTGAATACGTGACGCCGACCCGCGTCATGCTCACTTACGAGCTGCCGCTCAATGAGATCGTGCTCGACTTCTATGACCGCCTCAAGTCGGTGTCGCGCGGCTATGCCTCGCTCGACTACCAGCTTGCCGGCACCTGGGTCTCGCCCATGGTCAAGATGGATATTCTCGTCTCCGGCGAGCCCGTCGATGCGCTCTCGATCATCGTGCATCGCGACTTCGCCTATGAGCGTGGCCGCGCGCTGGTCTCAAAGATGCGCGAGCTGATCCCGCGCCAGCAGTTCGAGGTGGCCATCCAGGCCGCCATCGGGTCCAAGATCATCGCGCGCGAAACCGTCGCGGCCCTGCGCAAAAACGTCATCGCCAAGTGCTATGGCGGCGACATCTCGCGCAAGCGCAAGCTGCTCGAGAAGCAGAAGGAAGGCAAGAAGCGCATGAAGCGTATCGGCAAGGTCGATATCCCGCAGGAAGCCTTCCTCGCTGTGCTGAAGGTCGGCGAAGACAGCGCCTCAAAGAACTAGCCAGAGAGCGCACGAAGCTCCCGTCTTTGCCGGGCTACTGCGCAGTCTGCCGCACCCATTCCGCCATCTCCCGGCGCGCTTCAAACGACTGCGGCAATGCGGCCACCGTCAGCGGCCACACGGCAAAGTTGTGATGCATTCTGCCGTAATGAATATGCGTCACCGCCACGCCCGCCTCGGTGAGCCGCTCTGCATAGCGAATGCCCTCGTCGCGCAGCACGTCATACTCGCCCGTCATCACCAGCGCAGGTGGCAATCCGCTCAGGTCGCTCGCCCGCACCGGCGCAAAGCGTGGATCGCCGCGCTGCTCCTCCCCGGCAAGATACTGGCCGATGTACCAGCGCATGCTCTCCGCTTCCAGCCCGTAGCCGGTCGCATTGCTCTGGTAGGAGGCATATTCTTCCGGCGCGCCATCGGTCGCAGGAAACAGCAGCAGTTGCCCGCGCAACGTGGCCTTGCCGCTCAGCAGCAGCGCAACGGCCGCCGCCAGATTGCCTCCCGCGCTGTCCCCGCTCACAAAAACGCGCTTCGCATCGCCGCCCAGCTCCGCCGCATGCTCCAGCACCCACAGAGTGGCCGCTTCGGCATCTTCCACGGCTGCCGGAAACTTATGCTCCGGCGCAAGCCGGTAATCGACCGAAACAATCACAGCCTGCGTGAGGCCGCACAGATAGCGGCAAAAGGGATCGTGTGTCTCCAGCGAACCCACCACCCAGCCGCCGCCGTGAAAGTGAACGATCACGGGCGCGGGCTCCGCTGCTCCTGCCGAATAAACGCGCGCGGGTATCGCCCCGGCGGGGCCCGCAATCTCCACATCCTGCGTGCGTACCTGCGGCAGGTCGGGAAACTTCATCCCGGCGGCCATTTTCTGAACGTTGGCGCGAAGCTGATCGGGCGTCACCTGGTCGAGTGGCGGCGCGGGCGGAAGGCTATCCAGAAGAGCGCGAAGCTTGGCATCGATAGGCATAACGGCTTAGATGAAGCGGCTCCGGTGGGGATGCAATTCTGACGCCGCACGCACAACTCAGCCCGCCGCATGCACCGTCTGCGCCAGCAGAATCACGCCAATCACCATCAGGCCCACATAAACATACTTGAGAAATCTCTCCGGATGCATGCGGCGATTCACCCATCGCCCCAGCGGAATCACAGGCAGCAGCACCGGCAGCGAAATCAGGTAGTAGTGCGTGACCGTGTGCGTCCACAGCCCGGCGCGCCAGTAGCCCAGCATGCAGAGTGCGCTGGCCGGCAAAAAATATCCCTGCAGCGTGGCGCGAAATTGCGGCGCGGGCCACCGCCGCAGCGCCCCATAAATCACCAGCGGCGGACTGTTCATGCCATAAGCGCCGCCCAGCACGCCGGCCAGCAGTCCGCAGCCCAGCAGCAGGGGGCGATGATCGCGGCGAATCTGCCAGCGCTGCAGGCCCGTCAGCGAGAACAGTGCAAACCCCATCAGTAGCAGCGCCAGCGCAATCTTGACCGCGCCCTCATGCCCGCTGGTAAGCAGCATCAATCCCAGCGGAATACCAAAACACGTCGCCACCAGCCACGACAGCGCGCTGCCGAAGTGAATCTTCTTCCAGTCCTGAATCAGAATGACCGTTGCCACCGTGATGGAGAGCAGAACCGCGAGCGGAGCGGCCGTTTGCACCGGCATGCAGAAGGCCAGCAGCGGCACTGCCAGCAGCGACTCTCCAAACCCGAAGGTCGAGCGCACGCCGGTCGCCAGCAACACAATGAGGATCACAAACAGAGAAGTGGAGAGCATGAGAGTGCGTAATCCTGCGCCGAAGCGCTCAAGAGGTGCGAGCCAGTTTCATTTGGTGTCAGGGCATGCGAAGCAGAGCGAATCAGCCCTGCCGCATCACCGGCTTGCTCTTTTCATTCAGCTTCACATGCCCAAACGGCACGTGGTGGTCATGCGTGAAGAGCACCAGCCACTGCTCCGGAATCGCCCTCTTGTAAAACCGCTTGCGCTGCTCAATGCACGTGAGCGGATCAAGGTCATACCCCATCACCCACGTGATATCCAGGTGTGCGCTCGTCGGAATCAAATCCGAGATGTAGCATCCCCGCTGCCCCGCTGAATCAATGTTCACCGCGAGCAGTTGCGAGGTGTGTCCCGGATAACACTCCACCGAAATCCCGGGCACAATCTCCGTCACTTCATTGGGCCGCGTGTCCAGCAGCGTCATCTGCCCGCTCTCCACCAGCGGATCGTAATTCGGGCTGTTGTAGCTGACCGCGTCGCGCTCCAGTTGCAGGTGCCCGTGGGCTACTTCCCCTCGGTGCGCAAAGTAGCGCGCATTCGGGAAGGTCGGCACAATGCGTCCATCCGGCAGCTTCGTCGTGTTCCAGCCGCAGTGGTCAAAGTGCAGATGCGTGTTGATCACCACATCCACTTCTTCCGGCCGCACGCCCGCGGCCTCCAGCGCGCGCGGCAACTGCTCCTTGGCTTCAAAAATGGCGCGCATCTTCTCGCTCATTTTGTTGCCGAGGCCCGTCTCAATCGCCACGGTGTGCTGGCCCGTGCGCACAATCACCGTGTTGGTGCCCAGCAGAATGCGGTTCTGCGCATCCGCGGGCGCGCGCTTCTCCCACATCGGCTTGGGGACGACTCCGAACATCGCCCCTCCGTCGAGAAAGTAGTGCCCGTCGCTCACCACCGTCAGCTCAAAGTCGCCAACGGTGGTGCGGCCGCGCACCGGCTCGTGAGTATTCGCCCGCTCTGCAGGATGGCTCAGGGCTGCAGGATGCGCCATCGGTTATTCTCCTGCTCCGCCCGGCACAGGATGTTCAGGCATCAGGTACAGCTCAAACTCCTGCAGAATGCGGTTGTAGAGTTCGGTCTGGTCCAGCGCTCCGGCAATCGAGTGCGTCTTGCGCGGGAAGACGTTGTAGTCATATGGCACACCCGCTTCAATCAGCTTCTGAATGTACTGAATCGTGTTGGCAAAGTGTACGTTGTCATCGCCCGTGCCGTGCATCAGCAGCAGATGCCCATGCAGATGCGCCACGCTGTTCTGCACGGAGTCCACCTCGTACGCATGCGCATCTTCGCTCGGCAGGCCCATGTAGCGCTCCGTATAGATGGAGTCATAATTGCGCCAGCTCGTCACCGGAGCCACGGCCACACCCACGCGGAAGCGATCCGAGTGCGACAGTGCATACAGCGTGAAGGTTCCGCCCCAGCTCCAGCCCCACCAGCCCAGCCGGTGCGGGTCAAGTTGCGGATACTTCTTCAGCACCTGATCGACCGACGCAAGCTGATCGGCCAGCTCCGGCGGACCGAAGTTGTGATAGCACGCCTGCTCAAAGGCGCGGCCACGTGCGCCCATGCCGCGGTTGTCCATCGTGAGCACGGCAAAGCCATGCTGCGCCAGCAGCTCGTTCCAGAACAGATGCCGCCCGCCCCAGCGGTCTGTGGCCTCGCCCACATCCGGGCCGCCATAAGGATTCACGATCAGCGGCACGCTATGCGCGGCCGTCTTGCCCTCGGGCAGCATCAGCGTGCCGTAGAGCGTCGTCTTGCCGTCGGCGGCCTTCAGCGTCAAAAGCACCGACTGTTGCAGATCGTGGCCGGTCACCGGCGTCGAGGTCCAGAAAGAATGGCACGCACCCTGCGGATTGCAAAAGGCCACCGCTGGCGGAGTGGTCATGTCAGAGTACTCGTCAATGTAGGACGAGCCATGCGGCGGAAACTTCGGCTCATGCACGCCGCCCGTCTGCGAAACACGGCGCTTGCCGCTGCCATCCAGATTCACGGCCCACACCTGGTGCGCGCGCGGATTGCCCTCGTTCGAAACGTAGTAGATCGTGCCCGTAGCTTTGTCCACGGAGCCGATCGACATCACCTCGTAATCGCCGTGCTCCACTTCGTTCTCCAGCTTCGCGGGCGCGGCCATCGGGTCGGCCGCGTCAAAGCTGTAGCGGTAGATGTGCGTGTGCCCATCGCGCCAGCTCAGCAGCAGAAACTGGTGATCGCCCACAAACGTTACGCCATACGTCGTGTTGAAATACTTCGGCTCGGTCTGCGCCAGCGCCAGCTTCACCTGGCCCGTGTGGGTGTCGGCAAAGTAGATGTTTTCGTGCTTCTGTGCGCGGTCCAGCGTCTCCACCCACACAATGTGGTCATTCACCCAGCCAAAGCGCGGAATATACCCATTGCCCGTATCGAGTGGAATCTTCAGCCAGCTCACCGGCCCGCCCGCGGCCTTCACCACGCCCACGCGCACGCCGGGGTTCGGGTCGCCCGGCTGCGGATACCGCTGCCACCACTGAATGCGCGCATGCACCGGCAGCCAGTCTTCAATCGGGTAGAGCGGCACGCGGTCCTCATTCATCTGCAAAAAGGCAATCTGCTTCGAGTCCGGCGACCAGAAGTAGTTGCTGCGCACATCCAGCTCTTCGAGGTACACCCAGTCAATGCCGCCATTCAGCACTGTCTTTGAGCCGGAGTTGGTCAGCGCCCGCGCCTGCGAGGCATCCTGCTCCGGCTGTACGTAAACGTTGTTGTTACGAATGTAGGAGATGTACTGCCCGTTGGGTGAAAACTTCGGGTCGTCGCCGCTCTGCATGCCGGTGTTGCCCACCTTGCGGCCCTTGCCTTTTGCCGTGCTGAAGAGCCACAGCTCGCCATTCGTATCAAACAGCAGGTGCTTTGAGTCCGGAGCCCAGATGTAGTCCGGCTCGTCATAGCGGTTGCGGTGATCGCGGTCCTGCTCGCTGATCGGCGCGTTCAGCAGCGGCTCCAGCTCTTTGCTCGCGATAATCTTGCGCGCGCTCGCGCCGCCCACCACAAACTCCCGCAGGTTGCCGCTGCCATCCAGATAGGTGACCTGCTTCGAGTCCGGAGCCCAGTAGATCTGGTCCGGCGCGTAACCGGTCAGGCTGGGTCCGCCAAAGACTTCCTTCACCGTCCAAGGCTGAGCAGCCTGCGCGTGCAGCGCGGGGGCAGGGCAAAAGGCCAGGGCAAGCGGCAGCACGGCAGATTGCAGTGCGAGGGCAAAGCTCTTTCGAGTCAAAAGGGTGTACTCCCTGAAGATGATCTTTCGCGCCCGGCGCATCTCGAACGGCGCAGCGCGAAAGAGCATTCTAGTGCATCCAAAGGCAACATGGCGCAACAGAGATGTGTCCCTGTGCTCATCAGCCTGCCCGGAACGCAGTCAAAGGGTGCCACAGGCATCCCACAAAAGCCTTGTATGTGTGTTCGAACGATAGAAGGGAGATACGGGAAATCTGTATCAGGGCACGGCTTTAGCCGTGCCAAAAGCCCTGCAAAAAAAACGGGGCTTTAGCCCCTGCAGCCCGGCTGTGTCTGCGTGACCATCGAAGACCCTCGCAGTCAGCCTACTCGTACTTGAGCGACTCGACCGGGTCCATCTGCGCGGCGCGGTTCGCCGGCAGCGTGCCAAAAACCACGCCCACCGCGACCGAGGTGCCCAGCGCCACCAGAATCGATATGCCCGAAATAGGCAGCTTATAGCTGGTAAACAGGCGCACTGAGAGCGGCAGCGAGATGCCGATCAGCGTGCCCACCAGTCCGCCGGCGAGCGAAATGAAGATGGCCTCAATCAAAAACTGCAGTTTGATCTCCCGGGCCGTCGCGCCCAGCGCCTTGCGAATGCCGATCTCGCGAATGCGCGAGCGCACCGTCGCCAGCATGATGTTCATGATGCCCACGCCGCCCACGGCCAGCGTCACGGCGGCCACCAGCAGCAGGATGATCGTTAGCGCATTGGCAATGATGCCGGCCGTCGTGATCAGTGAGGTGAGGGTTGTCGCGGTATAAACAGAGTTCGGCTGGTGCCGCGACTTCACAATCTTCACAATCTGCTGCGCGGTCTGCTCAATGTCGCTCTGGTCGCGGGTCGAAAAGAAAATATCCTGCACATAGTCCGTGCCGGTAAAGTACCGCGCCACGGAGTAGGGAATCAGGATGGTCTCATCGCGAATCTCCGATTCGCCAAAGGTGTCCACGCTCTCTTTGAAGGTGCCGATGATCGTGAACGGAATGCCGCTGATCGTGAAGGTCTTGTTGATCGCATTCTGCGGACTGCCAAACATCAGCTTCGCCAGCGGCAGGGTAATGTCGGCCACCTGCGCGTGCGTGACTTCGTCTTCATCGTCAAAGAAGCGGCCCGTCGGCACGATGAGGTTGCGAATCTTGCGGTAGGGCGGCGTCACGCCCAGCACCAGAATGTCTTTCTCCACGCCGCTGCCCACGTCAATGCGGTCATGCATCTGCAGCAGGGGGGAGGCGGCCGCAATCTCGGGCAGTTGCTCTTCCACGGCGCGCATGTCGTCGAGCCGCAGGTAGTCGGTGCGGTAGTTGCTCACCGTGCCGCCGCCGCCGCCCGCGTACTCCAGGTCGATCATGTTGGTGCCGATGCTCTGCAGTTCGTGAATGATGAAGTGCTTGCCCGTCAGGCCGATCGTCACCACCAGAATTAGCGACATCGAGCCGATCACCATGCCCAGCGCCGTCAGCGCAAAGCGCATCTTGCTCGCGCGGAAGCTGTCCACGGCGAGACGCACAATCTCGCCCAGGCCCATCGTGCTGCGGGCGCTGGCCAGAGTGCTCTCAAAACTGCGGTGGGTATCGATCGCCATCTTTACTTTGAATGCGTCACGAGGTCAGGAGGGTTCAATTTTCGTTACAGAATCTGCCGGGCAGCCATGGACGAAGTAGATTCGCTCCGCCCACGGCAACCCAGCTTCATATCCTGCATCAGGCAGTCACAAACTCGCCCTTCACCATCAGCGGCTCATGGCTGCCGTCCGCATTCACGCCGTCCACGCTCACCTCGCCCGAGCCAATCATCCAGTCCACGTGAATCAGGCTCTCATTCGCGCCCTTCGCGGCCAGCTCTTCGGGCTTCATGTTTTCGCCGTTCTTCACGCAGGTGCTGTAGGCCTGCCCCAGCGCAATGTGGCAGGCGGCATTCTCGTCAAAGAGCGTGTTCCAGAAGAGCACGCCGCTGGCCGAGATGGGCGACGAATGCGGCACCAGCGCCACCTCGCCCAGCATGCGCGCGCCCGCGTCGGTCTCAATCATGCGCTGCAGCACGGCCTCGCCGGCGGCGGCATGCGCCTCCACAATGCGGCCATTCTCAAAGCGTACTGAGATCTTCTCAATCAGCGTGCCCTGGTGCGAGAGCGGCTTGGTGCTGGTCACCGTGCCGTTCACGCGGTCTTTGTGCGGCGTCGTGAACACCTCTTCGGTCGGCAGGTTCGGAATGCAATATTGCCCGTTGTGCGCCTGTGTGCCGCCGCCCAGCCACAGATGATCGTCCGCCAGGCCCACAGTCAAATCTGTGCCCGGCCCGCGGAAGTGCAGCGCATGGTAGCGCTTCTTGTTCAGGTAATCGGCGCGCTGATGCAGCTTCGCGTCGTGCTCCTTCCATGCCGCTACGGGGTCTTCGCGGTCCACGCGCGTCGCCGCGAAAATGGCGTCCCACAGGCGCGCCAGCGCCTGGTCTGCCGGCAGATCAGGAAAGACCAGCTTCGCCCAGTCCGGCGTCGCCGCCGGCACAATCGTCCAGTTGATCGCGTGCTTGGTGATCAGCTCCAGCGCCGGCCGGTAGGCAATCGAATTCGAGCGGTTGGCGCGGCCCACCTTTTCCGGGTCTTCTTTTGACAGCAGCGCCGGATTCGCCCCGGCCACGGCCATGCGCGCCGCGCCGCTCGCGTAAGCGGCTGCCATGCCCTCGTAGAGCCAGCCCGCGGCCTTGTCAAAGCTCGCATCCTTGCCGTGGCGGTAGCGCAGCAGCGTCGATGCCTCATCGCTCAGCAGCGTCGTGACCAGCGAAGCGCCCGCCTCATATGCATGCGCGGTGATGCGGCGCACCAGCGGCAGCGTATCCACGCTCGCGGTCAGCACCAGCTCCTGGCCCTCCTTGAGGCCAAGACCCACGCGCACGGCCACATCGGCCAGACGGTCGAGTTTCTGCTCAAAGGTCAGTGTTTTCTCAGGGGTAACAGCGGCAACACTCATGCAATTCGCTCCTGCCGCCATTATTTCACCATTCAGAGCACCGCCGCCGCGCCCGGCATAGTGCCGCTTCGGGTGCGGCTTGCGCAGTTTTTATTGCGTGCAAATAGGTGCAAAGCCGCGCAAATTAACGATCTATCGCCTTCCGCGCCATCACAACCCGGGGAATCCCCTGCAGATCATCCACAAAAGCTATGTCATCCCAGCCCGCCAGCAGCTCCGCAAGCGCCGCCCGCTGCCCATGCCCTATCTCCATCAGCAGCCAGCCTCCGGGCTCCAGCACCTCGGCGGCTTCCGGAATCAGCCGCCGGTACACATCGAGTCCCTCCGCCCCGGCAAACAGCGCGGAGTGCGGCTCAAAATCGCGCACCTGCGGCTCCAGCTCTTCGCCACCCGGCACATATGGCGGATTCGACACAATCATCGCAAAGCGCTCACCGCGCACCGCCGCCAGCAGGTCTGATTGCAGAAAGCGCATTCGCTCCGCCACGCCATGCGCGGCTGCATTTTCGCGCGCAATCCGCAAAGCCGCCTCTGAAAGATCCAGCGCCGTCACCAGCGCCTGCGGCCGGCTCGCCGCCAGCGCAATCGCAATCGCGCCCGACCCCGTGCCAATGTCGGCCACGCGCACGGTCTCACCCTCGGGCAGCCGCTCCAGCGCCGCCTCCACCAGGTGCTCCGTCTCGGGGCGGGGAATCAGCACATCCGGCGTCACCCGCAGCCGCAATCCCCAGAACTCCTGCTCGCCCACAATGTATTGCACCGGCTCCTGCGCGGCCCGCCGCAATATCCAGCTCTCAAATTGCGTGACCTGCTCTGCGGTCATAGCATCGTCAGAGTGCACGATGAGCCACGCGCGATTGCGCCCCAGTACATGCTGCAGCAATAGTTCGGCATCGCGCCGCGCCGTGGGCAGCCCCGCAAGGCGTTGCGTGGCCTGGTCAAGAATGGTGCGCACACTCGGCATTGTCGAAGCCATAACCTCTGATTCAGCGTGCTGCGACCGCAGCATCAGCCGCGGGGCTTTCGGTCCTGACAGCCCTTAAGCCACCGCCTCTGACTCCGCCTTCAAACGCTCCGCGTTAAAGTGCGCCGTCAGTGCATCAATCACCGGCTGCAGCCGGCCTTCCATCACTTCGGCCAGTTGATGAATCGTCAGCCCGATGCGATGGTCCGTCAGCCGGTTCTGCGGAAAGTTATACGTGCGAATCTTCTCGCTGCGGTCGCCGGAACCCACTTGCTGCTTGCGCTCCTTGGCCAGCGCCTGCTGCTGCCGCTCCATCTCCACTTCATACAGGCGCGAACGCAGCACGCGCATCGCCTTCTCGCGATTCTTGATCTGCGACTTCTCGTCCTGGCAGCTCACCACCGTGTTGGTGGGCAGGTGCGTGATGCGCACGGCGGAGTAGGTCGTGTTCACCGACTGCCCGCCCGGCCCCGAGGAGCAGAACGTATCGATGCGAAGATCCTTCGCCTCAATCTTCACGTCCACCTCTTCGGCTTCCGGCAGCACCGCCACCGTGATGGCCGACGTATGCACGCGGCCCTGCGTCTCCGTGGCCGGAACGCGCTGCACCCGGTGCACGCCGCTCTCATACTTCATCTGTGAGTACACGTGGTCGCCTTCAATGATGGCGATCACTTCCTTCGCGCCGCCCACCGACGATTCTGACATCGACAGCACTTCCACCTTCCACCGCCGCTGCTCGGCATAGCGCGCATACATGCGAAACACCTCGGCCGCAAACAACGAGGCCTCATCGCCGCCCGTACCCGCGCGAATTTCCACCACGACGTTCTTCTCATCGTTCGGGTCCTTCGGCAGCAGCAGCAGCTTCAGGTCCGCCTCAATCTGCGGCAGCCGTTCTTCCAGCGAAGCCAGCTCTTCCTCGGCCATCGCGCGAATCTCCGCGTCGGCCTCATTCATCATGCCGCGTGCATCGGCAATGCCGTTCTGCACCTCGCGGTACTCGCGAAACTTCTCCACGACGTCTTCCAACTCGCGGTGCTGCTTGGCGGTCTTCTGGTACTTCTGCTGGTCGGCAATCAGCGCGGGATCGGCCATCTCGCGGCCCAGCTCTTCATAACGGGTTTCAATCTGCTCAAGGCGTTCAAACATGGTGTGTGGCGCTCCAGCCGCCGATTCTGATAAGGAGGGAAATGAGGAAAAACGCAGACAAGGGCGCAGGCAGCGGGAGCTGCTAACGGTGGGCGCGAAGAGGAAGCGTCTGCTGCATCTACTGTTATTTTACTGCGTTTGTGTACGAATGTTACTGCGTTTATGCCGGAGTGGAACTATCTCAATCAGAAAGCAGCCTTCTCCATGACCCGTCCGGCTCCCCAAACTTCCGCCCCATTCGATGCTTTTGCCCGCTGCAACGATGCGCTGGCCGCCACGCCCGGCAAACTCGCCAGGCGCGAAATTCTCGTCGCATATCTCCGCCCGCTCGCCGTGCCCGATGCCGCCCGCGCCGCTTCTTCCGTTCCGCCCACGCTCACTCTCGCGGATGTCGAGCAGGCCTTCGCGCAAATCGCCGCCGCACGCGGCCCCGCGCCGCGCCTCCAGCGGGTGCGGCAGTTATTGGCCTGCGCCACGCCCCTTGAGATCAAATACCTCATCAAGCTCATGCTCGGCGACCTGCGCACCGGCGTGAAGCAGGCTCTTGTCGAGGAGGCCATCGCCCAGCTCCATGAGGTGGAACTGCCCACGCTGCGCCGCGCCCTCATGCTGAACGGCAGCCTGCCCGAGGTGGTCGCCATGGCAGCCGCGCATACGCTCCCTCAGGCGCAGATGCGCCTCTTTCATCCTCTCGGCTTCATGCTCGCCAGTCCCGTGGCCGGCGTGGAAGAGGCCATGGCGCGCTTTGCGTCCAAGCCGGATGCGCGGCAAGCCTCTGAACCTCCCACTGCCATCCAGATCGAAGACAAATACGACGGCATCCGCGCGCAGCTCCATTGCGGAGATCCCGCCCAGCCCGGCCGCGTCACCCTCTTCTCACGCAACCGCGAAGACATCGGCATCAGCTTTCCTGAGCTCATCGAGGCCTTCGCCGCCATGCCTGAGCCGGTCGTCCTCGACGGTGAAATCCTCGCCTGGCAACCTGCCTCCGCCACCGGGGCTGCGCGCGCCATGCCCTTCGCCGCGCTCACCCAGCGCCTTGGCCGCAAACGCGTCACCGCGCAAATGCGCGATCAGATTCCGGTGGTCTTTATGGCCTTTGACCTGCTCGCGCGCCATGGAGAACTGCTGCTCGACCAGCCGCTCTCCTCGCGCCGGCAGCAACTCGAAGCATTCCTCGCTGCCGCCTCTCCGCTCGCCTTGCCGGCCGGCGCCGCCCAAAGTTCCCTCTTTGCTGCGGAGGAATCAGCAGACTTCTTGCGCCTCAAGCTCGCTCCCGCCACGCAACTGGAGTCTGCCGCGCAACTGGACCGCGCCTATCAGGACGCCCGAGCGCGCGGCAATGAAGGCGTCATGCTCAAAGCCCTCGCCAGCCCTTATCAGCCGGGCCGCCGCGGCCTTGCCTGGCTCAAGCTCAAGCGCGAGCTTGCCACGCTTGATGTTGTCGTCACGGGAGCCGAATTCGGTCACGGCAAACGCGCGCACGTCCTCAGCGACTACACCTTTGCGGTGCGCGATGGCGAAGAGCTGAAAAACATCGGCAAGGCCTACTCCGGCCTCACCGACGCCGAGATCGCCGCGAATACAAAGTTTCTGAAAGAGCACACGCTCGAAGACTTCGGCCACTTCCGCTCCGTCGAGCCACTGCTCGTGCTCGAGGTCGCCTTCAACAACATCCAGCGCTCTGAGCGGCACAACAGCGGCTTCGCGCTTCGCTTTCCGCGCATCGTTCGCATCCGCGACGACAAGCCGGTCGAGGAGATCGACACCCTCGCCCGCGTCGAAGAGCTTTACCAATCCCAACCGGACAAGCCCCCGGAGGCTTAGTTGCGGGTGCCCCACATCTCGATTCTGAGATGTGGGTTTTCGATGCTCCATCCTTGTTATCCGGCAGAACGCTCGTATCGGGGCATGGCGTTAGCCCCTGTCACAGGGCGGGTGCCCCACATCTCGATTCTGAGATGTGGGTTTCGCGGTCCCATCCTTGCGCATAGAGCAGAGCACTTGTATCAGGGCATGGCTTTAGCCATGCCATAATCCCTGCGAAAAGAACGGGGCTTTAGCCCCTGCCATTCCAATTACGGATTACTGGAAGCCGCAGGCGTCCCCGCCAGAATCGGCTCTCCCGCCGTGCCCATCAACTGCGGCAGCAGAAAGTGAAAGAACTTGTCCGAGTCCGAGTGCAGGCACACATTCGCGTTCGGCGTGCCGCTGCCCACATGCGTGAAGCCGCGGTTGCCAATCACAATGTCCATCGGCTGCGTGGGGCACAGCGAGGGATCCATCACATACGCCACAGCCATCGCGTCATATAGCGTTGGCGTGGGGTTCTGCATCGCCGCTGTCCATTCATTCGTGAGCGTGCTGAGCGTATCCGTCAGCGGCGTCCCTGCGCTGAAGACAATCGGCCGCATCACCTCATCCAGCTTCAGTTGCGTGGAGTCGAGCGGCATCATGTCAATCGGCACGCCCGAGGCAAAGAGCTTCTGTGCTGCCGGAATATCAGACGCAATGTTGTACTCCGCGCTCGGCGACTCACCCGGCAGATAGCCAAGATTGCCATAGCCCTGGTGGATCGAGCCGCCCATCAGCACCACGCGCTTCAGTTGCTTAAACGTCGCCGGATCGCGCGCAATCAGCGCCGCCAGATTATGAAACGGCGCCAGCGCAATCAGCGTGATCTGTCCGGGATATTTCTTGATTTCGCTCTGCAAAAACTGCACCGCATCGGGCCAGCTTCCCGGCCGTGCCTGGTAGCCCTCGGCGTAATACTCCTGCGTAAATGCAGCCGTCGGCTGCGTGTGCAGGCCAGCCGCTACCGGAATATCCGAGTGGCCCGTCGCATCGAGAAACCGCTTCACCAGCCGCGCGCGCAGCGTCGTGTCGCCCCAGTCCGTCGTGACGCCCAGCACCTGCAACTGCGGCGAAGAAACCGCCAGCCCCAGCGCATACGCGTCGTCGATATCGTCTCCAATATCGGTGTCGATAATCACCTTCTGCGGCGGAGCCGTCACGGCATTCGCTGTTCCGGGTGTCGTCTGGCTTGCCGAAGCCGCAGGCGTGTTCTGCGTGGCTGAAGTCGTGGCCGGCGTCGTGGGTGCTGTCTGCGCCATGCCCGGCAGTGCGCTCACCGCGCACAGCAAAAAAGGGGTTAGCAATTTCCGCATCATCTGCCTCTAATGGACGTGCCCATGCTCATGATCGTGAGCATGGCCGTGACTGTGGCCGTGATGATGTCCATGGCCTGCGTCGCTGACCTCGAGCGGAGAAGCGCAGCCATGCGACACCTCGCACGGCGCATTCTCAAACTGCACTGTCGTGTGCTGAATGTGAAACTTGTCGCGCAGCATGCAGCGAATGTTCTCCAGAATCAGTTGGCTCTCTGACGGCGGAATATCCGGAATCGTCACATGCGTGGCCAGCGCGTGGCTGTTCGAGCCCAGGCTCCACACATGCAGGTCGTGCACATCTTCCACGCCGTCAATGGTGCAGAGCCGCGTGCGAATCTCTTCCAGGCGCAGCCCGCGCGGCGTGCCTTCGAGCAGTATGTTCAGCGTCTCGCGCACAATGCCCAGCGAAGACCAGAAGATCATCGCCGCAATGCCCAGCGAGAGCGCCGGGTCCACCCACGTCATGCCAGTGAAAAAAATCACCACGCCGCCCACAATCACAGCGGCCGTGGAGAGCGTGTCGCCCAGCATGTGGATGTACACGCTGCGCATATTCACGTCGTGGCTCACGCGCCACAACAGCGTCGCGATGACGCCGTTCATCAGTACCCCGGCGGCGGCCACCGCCATCATGATCTTCGGATGCACACCCGCCGGATGCTGAAACCGCGCCACCGCTTCCCAGGCAATCCAGACTGAAATCACCATCAGCGCCAGCGCATTCAAAAATGCCGCCAGCACTCCCGCGCGATGATATCCAAAGGTCTTGCGAGGGTTGGCCGGGCGCATCTGAAAGTAGACGGCCACAAATGACAGCACCAGCGCCAGCGCATCCGAAGCATTATGCCCCGCCTCTGAGATCAGCGCCAGCGAGTGCGCGCGCCATCCGGCAAAGAGCGTCAGCCCGACATAGCCAAGCGTCGCCGCGACAGAAAACTGCAGCACGCGTTGCGTTTTTTTCGTGGGTGCGGCGTGTACGTGCATCTTTTATCAGTCTATCGGCAGCAGCCTGCGGCGGGGAAATGACCGCTCTCCCCCCGAAAAACTGGCTCTCCTACGCTGAGGTCGTCGTCCGGGGCGTGCGCTGCGGAGGAATCCCGCGCCGCACCGGCACGCCTGAGGCAATATCCCGCAGCCCTGACCAGGTTTCGGCTACCACAATGCTGTTGGTGGGCCGGTGCGTGTCATACCGCACCGAGCAGGGAAACCCCAGCCGCATCTGGTGAATATCGAGATATTCGCTCAGCGTCGAGACATCCTGCGAGCACTCGTACACCACCCCGGCAATCTCATATTTGTACAGAATCAGTTGCATGCCGCCCTTGCGGCCGCTCTCTTCTTCCGTCAGGTCTGAGACGTCGAGCACCGTGCCGTCAATCAGCCGCCCCATCCGCACCAGATCCTCGCGCCGCATCCGTTCCAGGTCGTCGGCGGTGGGGCGTTTGCGCAGCATCAGCCAGGCCCCGGCTCCGGCGGCAAATAACGCGAAAACGGCTGCTGTTCCATACACCTGAGGGTCGCGCAAGTTATACACCGGCAGAGCTCCGCAATCGGCAAAAAGAACCAAGGTCGTGCAACGGCAGAATACCTCAGGTCCATCCGGATTTCTCCTCCCATTCTGCCCCGCACCATGACCTTCTGTTCACAGTGGGAAAAGCCCCATCCTGCCCCGCTCGGAAATCGCCCGTGCCGCCCCGCCATCACCGCCCGCCGCCGCAGGGACGCTGTCCCGCCGCCGCTCAAATCCCCGCCACGCGGGCGATATACTCAAAAGAGCATGTCAACTCGCCGGAATTCTTCGTTAGCCGCCCCGGGCGGCGATTCTTCTTTCCACACTTCGCAGGCTGCCCGCGCGCCGCGCATCCGTTCCACCACCGTCATCTGCGTGCGCCGCGGCAACAGCGTCGTCATGGCCGCCGATGGACAGGTCACCATGGGCGACGCCGTCATCAAGCAGTCCGCCCGCAAGGTGCGCCGCCTCTATCAGGACAAGGTGCTCGCTGGCTTTGCCGGTTCCACCGCCGATGCCTTCTCCCTCTTCGGCCGCTTTGAGGGCAAGCTCGAGCAGCACGCCGGCAACCTGGGCCGCGCCGCCGTCGAGCTCGCGAAAGACTGGCGCACCGACAAAATGCTCCGCAACCTTGAAGCTCTGCTTATCGTGGCCGATCCCCATCAGATGTTCCTCATCGGCGGCGCCGGCGACGTCATCGAGCCCGACGAAGGCGTCACCGCCATCGGCAGCGGAGGCTCCTACGCCATGGCCGCCGCCCGCGCCCTGCTCGAAAACACCGATCTCTCCGCCCGCGAAATCGCCGAAAAGGCCCTCCGCATCGCCGGAGACATCTGCATCTACACCAACGGCCACATCACCCTCGAAGAACTGCAAGCCTAGCGCTCAGAAAGGAGCACGCCCTCATGGCCATCTATCTACCCGGCACGGCCGAAGATCAGGAGCTCGCGCTCGATGAGCTCACCCCCCGCGAAATCGTCGGCGAGCTCGACAAGTATGTCGTCGGCCAGAAGGCCGCCAAGCGCGCCGTCGCCATCGCCCTGCGCAACCGCATGCGCCGCCAAAAGCTCACGCCCGATCTCGCCGATGAGATCATGCCCAAAAACATCATCATGATCGGCCCCACCGGCGTGGGCAAAACCGAAATCGCCCGCCGCCTGGCCAAGCTCACCAACTCGCCCTTCCTTAAGGTCGAGGCCTCCAAGTTTACTGAGGTGGGCTACGTGGGCCGCGATGTCGAGTCCATGGTGCGCGACCTCGTCGAGATCGCCATCGACATGGTGCGCGAAGAAAAGCTCGAAGAGGTCGAAGACAAGGCCGAGCTCAACGCCGAGGAGCGACTCCTCGATCTCCTCCTGCCGCCGCCCGCCACACAGACCCCCGCCGCCGCGCCCGCAGGCGCCGGCGAAACCCCGGACGCACACGGAGCCATCATCCTCCCGCCGCCCGCCGCCTCGGCCACGCAGGAGTCACAGCAGCGCACCCGCGAAAAGCTCCGCCAGCAATTCCGCGAGGGCAAGCTCGATGACCGCATGGTCGAGCTGGACGTGCGCGAGCGCGGTGCGCCGTCCTTTGAAATCATCTCCAACCAGGGCGTCGAAGAGATGGACATCAATCTCAAGGACGTGTTGCCCAGCATCTTTGGCCAGCGCACCAAAAAGCGCAAAATGAAGGTCGCCGAGGCCTTCGAATATCTGGTGCAGGAAGAGGAAAGCCGCCTCATTGACATGGATCAGGTCACCCGCGCCGCCGTCGAGCGCGTCGAGACCTCCGGCATCGTCTTCCTCGACGAAATCGACAAGATCGCCGGTCGCGAAGGCGGCCACGGCCCCGACGTCTCGCGCGAGGGCGTGCAGCGCGACATCCTGCCCATCGTCGAAGGCACCACCGTCAACACCCGCTACGGCATGGTGCGCACCGACTACATTCTGTTCATCGCCGCCGGAGCCTTCCACGTCTCCAAGCCCAGCGACCTCATCCCTGAGCTGCAGGGCCGCTTCCCCATTCGCGTCGAGCTGCAGTCGCTCACCGTCGAGGACTTCATCCGCATCCTCACCGAGCCCAAGTCCTCCCTCGTCAAGCAGTCCACCGCGCTGCTTGAGACCGAAGGCCTCAAACTCGAATTCACGCCCGAGGCCATCGCCGAGATGGCGCAGTTTGCCTTCAGCGTCAACGAGACGACGGAGAACATCGGCGCGCGCCGCCTGCACACCATCATGGAGAAGGTGCTCGACGACATCAGCTTCCTAGCCCCTGACCTCATCAAGCACGGCAAGGGCAAGTCCGAGGCCGGAGTCGTCGATCTCGCCGCCGCCGCCAACGGCCACGCCGAGATGGCGCCCATCGCGCCCCTGCCCGTCATCGAGCGCGAAACCCCCGGCGGCACCGAGTTGGTCGCCGTCGTCGATCCCGAATACGTCAAGCAGATGGTCGCCTCGATCGTCAAAAATCAGGACCTCTCGCGCTACATCCTCTAA

Protein sequences of DBSCAN-SWA_1

>NC_012483|3000618:3073984|3068905_3069940_-|WP_015897718.1|DBSCAN-SWA
MAQTAPTTPATTSATQNTPAASASQTTPGTANAVTAPPQKVIIDTDIGDDIDDAYALGLAVSSPQLQVLGVTTDWGDTTLRARLVKRFLDATGHSDIPVAAGLHTQPTAAFTQEYYAEGYQARPGSWPDAVQFLQSEIKKYPGQITLIALAPFHNLAALIARDPATFKQLKRVVLMGGSIHQGYGNLGYLPGESPSAEYNIASDIPAAQKLFASGVPIDMMPLDSTQLKLDEVMRPIVFSAGTPLTDTLSTLTNEWTAAMQNPTPTLYDAMAVAYVMDPSLCPTQPMDIVIGNRGFTHVGSGTPNANVCLHSDSDKFFHFLLPQLMGTAGEPILAGTPAASSNP
>NC_012483|3000618:3073984|3020739_3020985_-|WP_052294804.1|DBSCAN-SWA
MLRLEDFMEIQKLHHEGWSVTEIARHLSIDRKTVRKYLREAPRAYERKPKSWKIDPWRPWLRERWEQGVHNASRLFMEMRK
>NC_012483|3000618:3073984|3030570_3031503_-|WP_012680514.1|transposase|DBSCAN-SWA
MDIHQNARLTPYSREQLARKVICTGCTLKLAAASFNVSAKTAGKWVRRYRAEGSDGLRDRSSRPHRSPRRLPEALRLSVIELRRGYMPGYQIARRSAVSVSSVSRILRRARLSRWRDLNPPPPVVRYEHAAPGDLLHLDIKGMTRFGEVSLRGDGRLRGKKEHPGFLALHVAVDDHSRMVFAQMLADQKAETTIGFLHAAVEFFASHGIGIRALLTDNGSSYRSRQFRQACQQMAIKHSRTRPYTPRTNGKAERFIQTAMREWAYAKHWTDSSQRDQHLQSWIHYYNHERPHGSLNYKPPSSRSQEGTTS
>NC_012483|3000618:3073984|3038676_3038940_+|WP_015897693.1|DBSCAN-SWA
MDTQKVGIREFRDKLATYLLESETPVAITRHGDTVGYYIPARRRRSEAEREALKEAFGHWQQILKAEGISEDEVLADFKTWRAKQKQ
>NC_012483|3000618:3073984|3005235_3005553_+|WP_169305975.1|DBSCAN-SWA
MATYRHLGLDDRVQIQVLTKRGISDAEIARELQVHRSTVGWERRRNKVGSKYYHHQAQACADRRQRERRQRPSKLTPAVVAFVEEKSCVGDWEEQQVASLRYLSM
>NC_012483|3000618:3073984|3028351_3029143_+|WP_015897684.1|DBSCAN-SWA
MTDHLSTLQNRIQPYRAQLAEHPLYASLETLEDLRLLMQSHVFAVWDFMSLLKSLQRTLTSVDVPWQPTADAAARRFVNEIVLGEESDHHNGRTFSHFELYLEAMQQSGAGTRPVQSFISALRAGQSVEQALSFTPVPAAAANFVRSTFAVIEAGSLPAIAAAFTFGREDLIPDMFRGFVRELNATKPGQVETFLFYLERHIELDGDDHGPLALRLIQSLCADDATRWQEATHAAEAALKARLALWDAIYAEVITRQYAPVAS
>NC_012483|3000618:3073984|3072412_3073984_+|WP_015897722.1|protease|DBSCAN-SWA
MAIYLPGTAEDQELALDELTPREIVGELDKYVVGQKAAKRAVAIALRNRMRRQKLTPDLADEIMPKNIIMIGPTGVGKTEIARRLAKLTNSPFLKVEASKFTEVGYVGRDVESMVRDLVEIAIDMVREEKLEEVEDKAELNAEERLLDLLLPPPATQTPAAAPAGAGETPDAHGAIILPPPAASATQESQQRTREKLRQQFREGKLDDRMVELDVRERGAPSFEIISNQGVEEMDINLKDVLPSIFGQRTKKRKMKVAEAFEYLVQEEESRLIDMDQVTRAAVERVETSGIVFLDEIDKIAGREGGHGPDVSREGVQRDILPIVEGTTVNTRYGMVRTDYILFIAAGAFHVSKPSDLIPELQGRFPIRVELQSLTVEDFIRILTEPKSSLVKQSTALLETEGLKLEFTPEAIAEMAQFAFSVNETTENIGARRLHTIMEKVLDDISFLAPDLIKHGKGKSEAGVVDLAAAANGHAEMAPIAPLPVIERETPGGTELVAVVDPEYVKQMVASIVKNQDLSRYIL
>NC_012483|3000618:3073984|3021135_3022041_+|WP_083770606.1|DBSCAN-SWA
MDALWCGLDGRRVNWVLDLDVRSFFDTLSHAWLVQFLQHRIADRRVVRLIQKWLNAGVLEEGKRTQVEMGSPQGGSASPLLANLYLHYVFDLWVQTWRQKRAHGEVIVVRYADDIVVGFEFKDEAERFWLELKERMEKFQLELHPEKTRLIEFGRHAAANRKRAGLGKPETFSFLGFTHICGKTKRGRFMVLRQTVRKRMQATLQRIKTELRQRMHDPVPEVGEWLKSVVGGHIRYFGVPGNRYALAHFRLTVSRLWQRALTRRSQKGRVPWERMQRLIRRWLPPAHIYHPYPSRRLRVIT
>NC_012483|3000618:3073984|3065750_3066827_-|WP_015897716.1|DBSCAN-SWA
MFERLEQIETRYEELGREMADPALIADQQKYQKTAKQHRELEDVVEKFREYREVQNGIADARGMMNEADAEIRAMAEEELASLEERLPQIEADLKLLLLPKDPNDEKNVVVEIRAGTGGDEASLFAAEVFRMYARYAEQRRWKVEVLSMSESSVGGAKEVIAIIEGDHVYSQMKYESGVHRVQRVPATETQGRVHTSAITVAVLPEAEEVDVKIEAKDLRIDTFCSSGPGGQSVNTTYSAVRITHLPTNTVVSCQDEKSQIKNREKAMRVLRSRLYEVEMERQQQALAKERKQQVGSGDRSEKIRTYNFPQNRLTDHRIGLTIHQLAEVMEGRLQPVIDALTAHFNAERLKAESEAVA
>NC_012483|3000618:3073984|3051816_3052386_-|WP_085947585.1|DBSCAN-SWA
MEDEQEFAVPAAAVTEAEFLLVAEEAPKAPAVKKPAKKAAAKKAPAKKAAKKTPAKKAAKKVSAKKAVKKAAAKKPATKSAAKSSSKRALSGGAVKKKSSAAKSTSSKKSTKRGTPLAVKTAKKAPAKKAAAKKTAVKKAPAKKAAAKKAPAKKVAAKKTAAKKAPAKKAAAKKAPAKKAAKKAAPKKK
>NC_012483|3000618:3073984|3002754_3003501_-|WP_015897665.1|DBSCAN-SWA
MALRVSQTVRWGMALLLTGAVAAGAQTIQVSKANRTLAVTSNGTATATADRAVLSVGYSVYGPTSEAAYAEASKTSNAIADALAKAGVAKDQIESQSESVMETQAYENQNLTPAEREARKYHAEQTWAVRLKAGEVARVLHAAVTAGANNSGNIQWSVADDEALLAKAAAKALANDKRMAATMAEGLGVTLGPLLYASNRGPTLTPTPIFHAMMMAKSAAPQEAVKPLSIEPERITDSATVYAVFAIQ
>NC_012483|3000618:3073984|3036396_3037824_-|WP_015897691.1|protease|DBSCAN-SWA
MDHKQYFFEKFGITERLLERCLGEALSAGGDYADLYFESVTASSIGLDESIVKTASHGVSAGCGIRVLSGERTGYAYTDDLSADRLLRAARTAALIASGPAKQPVQGFTETRTPSLYPVPGAEADIDITAKLNLLHRADKVARGYDSRITQVRASYADELRRILIAASDGTFASDTQPLARMNVFVLAKNDERTAQGTSGGGGRVEIDYFETEKTPEHFAREAARTALLQLGAVAAPAGEMEVVLGPGWPGVLLHEAVGHGLEADFNRKKTSAFAGLIGRPVASEKVTVVDNGTLKNRRGSLNVDDEGSATQETVLIENGILKGYMSDKLSARLMKMPHTGNGRRESYQQIPMPRMTNTYMLAGEDAPEDILRSVKRGLYAVNFGGGSVDITTGKFVFSASEAYLIEDGKVTAPVRDATLIGNGPEALKYVSMVGHDLALDEGVGTCGKDGQSVPVGVGMPTVKLDRMTVGGTGR
>NC_012483|3000618:3073984|3042575_3043358_-|WP_015897697.1|DBSCAN-SWA
MATEEKEGIPSVEIDPASAEAFISEKRIGERIKRLRLKKSMGLVELGRHTGLSASFLSQLETGRVVPTLRNLARIAMVFSKDLSYFFETEPHTLFRVHKKKERVRLPQTGVDDPTYFFESLGYMVPDRMLDPYYAEFVPLKKGTEVRAHVHPGFEFLYVISGELEIKHGEKLHVLEGGDGVYFDASTPHAYQCAGKTPAAVVIVTMHQQAAHTAAGLRSMSASLSSRPSAATPGSARPATALGSERGGAAGLSPLRTPRA
>NC_012483|3000618:3073984|3051182_3051731_+|WP_015897705.1|DBSCAN-SWA
MSRFWIIVLVAVVVTLGGLALRSFAAKVPGMPRVGQMAPGFTLPNQEGQPVSLDSQRGKWVVLYFYPKDMTPGCSIEAHNFQRDIEKYHAANALILGVSLDTVKSHKKFCTKDGLGFTLLSDHQAQVSKDYGVLGNYMGFKIDHRVTFLINPEGRVVKVWPKVSPSGHSEEVLAELAAQQKA
>NC_012483|3000618:3073984|3019737_3020703_-|WP_169305977.1|transposase|DBSCAN-SWA
MREWRSEDRERAFVRFETEPGEQAQMDWGHFGNWGGRRLYGFALTLGWSRMQYAEFTQRQDVETLLNCMVHAFRHFGGVTATVLTDNMKTVVLDRIDGQPRFHTKMLDFASYYGFVPRVCHLYRPETKGKIESTIRYIKSSFWPGTSFDSLPELNHQALVWCEEANRRVHGTTREVPLERFAREGLTPLGGQPDYDTSYLSHRQVAKDCLLSYRGNRYSVPHAYAGKSVAVREPLDVRVIRIFHQRDLIAEHRMATGKGQAVIDPAHYAGLPRRVRRSTAPISAPTTELTPGPGVGLHHPVPVVELRSLDIYEEVAHVATV
>NC_012483|3000618:3073984|3001369_3001657_-|WP_083770683.1|DBSCAN-SWA
MNDYQFKVVKLKGEFVWHQHEDTDEAFLVIEGEMEIGFRDRTVTLGAGEMFVVPRGVEHITRAAGECHALILEPRGVVNTGDAGGALTAANDVWV
>NC_012483|3000618:3073984|3044443_3045577_+|WP_015897699.1|DBSCAN-SWA
MTTAGAKSAAAGKRALSAAALLLAGLLTGCALEAAPSPPSLKIPTPVKDLTATRAGAAVTLHWTMPKRTTDKALLKGPQPVVVCRAVLPIAADAACQPIATLHFAPGQAASWTHTLPPALLAGTPRLLAYSVELYSPWKKTAGLSNAANVVAGAPPPPVGPLRLTTRKDGIVMHWQPASAEPHMVMRIHRTLVAPPHAKQPHASAGNMAGEGPAPEQVLEISLSRRDPGQAIDRDAALNHTYTYVLQRVLELKVNGAAAELPGAPSQPVTVNAKNLFAPAVPRDLEAVADAAARAIDLSWQPSPESDVTGYAVYRRIAGSGGAWQRISPAKPLLAAPAWHDAEAEPGVTYEYAVTAISSNGLASPRSAPVSEALPAQ
>NC_012483|3000618:3073984|3038001_3038535_+|WP_041839554.1|DBSCAN-SWA
MATPTVDSARFPIGLFDRAAASLDHKAAIAILAALPENMRSAVSGLSDAQLDTPYREGGWTLRQVVHHVADSHGQAYARTRMALTEDWPVIKPYHEALWAELSDARTAPVELSLELLASLHARWVLLLQSLTPEQWERGYDHPESGRHTLTQVVALYDWHSRHHLAHITSLRERMGW
>NC_012483|3000618:3073984|3059480_3061739_-|WP_015897712.1|DBSCAN-SWA
MTRKSFALALQSAVLPLALAFCPAPALHAQAAQPWTVKEVFGGPSLTGYAPDQIYWAPDSKQVTYLDGSGNLREFVVGGASARKIIASKELEPLLNAPISEQDRDHRNRYDEPDYIWAPDSKHLLFDTNGELWLFSTAKGKGRKVGNTGMQSGDDPKFSPNGQYISYIRNNNVYVQPEQDASQARALTNSGSKTVLNGGIDWVYLEELDVRSNYFWSPDSKQIAFLQMNEDRVPLYPIEDWLPVHARIQWWQRYPQPGDPNPGVRVGVVKAAGGPVSWLKIPLDTGNGYIPRFGWVNDHIVWVETLDRAQKHENIYFADTHTGQVKLALAQTEPKYFNTTYGVTFVGDHQFLLLSWRDGHTHIYRYSFDAADPMAAPAKLENEVEHGDYEVMSIGSVDKATGTIYYVSNEGNPRAHQVWAVNLDGSGKRRVSQTGGVHEPKFPPHGSSYIDEYSDMTTPPAVAFCNPQGACHSFWTSTPVTGHDLQQSVLLTLKAADGKTTLYGTLMLPEGKTAAHSVPLIVNPYGGPDVGEATDRWGGRHLFWNELLAQHGFAVLTMDNRGMGARGRAFEQACYHNFGPPELADQLASVDQVLKKYPQLDPHRLGWWGWSWGGTFTLYALSHSDRFRVGVAVAPVTSWRNYDSIYTERYMGLPSEDAHAYEVDSVQNSVAHLHGHLLLMHGTGDDNVHFANTIQYIQKLIEAGVPYDYNVFPRKTHSIAGALDQTELYNRILQEFELYLMPEHPVPGGAGE
>NC_012483|3000618:3073984|3000618_3001320_-|WP_015897662.1|protease|DBSCAN-SWA
MNQQIVIKIFEFVLLLFALSLHEASHAWMASRLGDQTARMLGRVTLNPVKHIDILGTIILPLVMLFAPGFGQFLIGWAKPTPVNGRNFKHYKRDDMLVTLAGPGSNLVIALVSVVLLVVLAKAAPGGELVVHALAAGAWGLALTQGGAVVPVGLLLYLSVWLNLMLTIFNLLPIPPLDGSHILRNLLPYNALKFYDSLGGWIGLALIIFVGAPVMDFFLSPLLAMVNMILLRV
>NC_012483|3000618:3073984|3047720_3048431_-|WP_041839556.1|DBSCAN-SWA
MFTAFIDESFDDKNLGRFAVAAVFGNGWSALRGETLWRELLCKHKLRSFKASKLQGKPEVRAEFAMAIADSGLIASGLITDQTVVREHLNGSSLHKQYKENPYMLMYQTIFVRIAMDLRRAGATDSVSFVCDENGRYRDILTRSYPELKSRNPNAAEYMGSCTTADDESYVQLQMADLIAWELRRAGTSIGDLGEEASAPLQILLDRKTLWFCGHLDEERVRTIREIVDKSVSEGV
>NC_012483|3000618:3073984|3048929_3049490_+|WP_015897702.1|DBSCAN-SWA
MDTPNPILDGKQTLDIREIMSILPHRYPFLLIDRVVEIERKKRIVAIKNVTMNEPFFQGHFPGMPVMPGVMVIEAIAQAGGTLLMPEVPDRDKLLIMFTSIERAKFRRPVVPGDQLRIEIDVLNWKPRRAKMEGRALVDGKLACEATVMCQLVPRPDAQATEAAPAAESGAESAPAQEAISTVSAE
>NC_012483|3000618:3073984|3010691_3012623_-|WP_083770605.1|DBSCAN-SWA
MPTVYHVGKQKSHVNSLSHSVRISDNSPPPQAKKYLITAFIYKIPGSREVLRVNTGRSYSVPYSRHAFVTVYIRVLLAAVPLLMLLTPALAESAKRDYKIGQAAEARNDAIAAYRAYKSASELKPGEIRYRIAFERVRTAAAEEYVKEGQGFATHGNLAPALAAYLKALDADPTNEMAESDARALELRLQQNTHTQASTAPSGSAENMPESPVDLDIPVAGPVTLHMLADSKVIYLTIGKLLGINVLFDPSSSSNRIQVDLSNVTPYQALNIVGKVSGTFWQPVTHNTIFVAQNTPAKRKEYSNQALEVFYVGNVSQASDFTGIQTALRNVFQSARIFGIESNDTIVMLGTPDELRLAKMLIASLDEPKPEVLVDVTVMEVSRDKMREIGLSPPTSLTVNSGSSQTLEQIGHTSAYSITIGQAAADFLLTDSNTQILQNPRLRALNGEQASLKLGERLPVATGSYTYATGSTSAAAETQFQYLDVGVNIDMTPQIHLDHTVTLKLGVDVSSENGTEDLEGVEEPIISQEKAQQIVRLKNGESTILAGLLKKEVSQTVSGWPGFGEIPFMKYLFTTQKHEVTSDELVFMITPHIIRSPQVDPLTMREIDTGTADMIQLREPPGQLNSSLAAKPKAASSQAASHP
>NC_012483|3000618:3073984|3056749_3057682_-|WP_015897709.1|DBSCAN-SWA
MPIDAKLRALLDSLPPAPPLDQVTPDQLRANVQKMAAGMKFPDLPQVRTQDVEIAGPAGAIPARVYSAGAAEPAPVIVHFHGGGWVVGSLETHDPFCRYLCGLTQAVIVSVDYRLAPEHKFPAAVEDAEAATLWVLEHAAELGGDAKRVFVSGDSAGGNLAAAVALLLSGKATLRGQLLLFPATDGAPEEYASYQSNATGYGLEAESMRWYIGQYLAGEEQRGDPRFAPVRASDLSGLPPALVMTGEYDVLRDEGIRYAERLTEAGVAVTHIHYGRMHHNFAVWPLTVAALPQSFEARREMAEWVRQTAQ
>NC_012483|3000618:3073984|3005682_3008664_+|WP_148215143.1|DBSCAN-SWA
MFVTAIRDKRNFLLNGERAGLMSSRSFAKVRVAGLNIRLFFRACVVAGYLLCIMYVGIAAGEVQSRITGTVNSNQAVSLQGSAFPSARPQNRVGPMSVDTQLTGITIDFKPTIAQKAELDALLKAQQTPGSSWYHKWLSPAEYASEFGLSDNDLSKIERWLQDQGFTIDRVANNHSYITFSGTVSQVNSAFATEMDYYKIADKTHFANATNLSIPSALSGVVESVRNLNDFRPRPHVRFHLSHTGAVRPGFTSSESGSHYLQPGDVATIYDITPAYDAGYTGSGQSIAVVGQSEIDVSDIEHFQSAAGLTEKAPTLVLVPGSGTAAFSSDDEAESDLDLEYAGGIAKGAAIYFVYVGNNQNYSVFDALQYAVDTKIAPIISMSYGACEMELSSDDYSSLESIMEEAASQGQSVIVATGDDGSTDCYGESGLSETKQEDLAVDYPASSAYVTGVGGTEFPAADIASSNTTYWESASGSDVITSAKSYIPEVAWNDDSTCAEYVSDGSSPLCSGGGGVSTLTARPSWQSGVTGIPSGGYRLVPDLSLNASPVNGGYLYCTSDTSAWSEGQQASCSDGFRDSATQDLTVAGGTSFDAPIFAGMLAILNQKENSTGQGLINSTLYQLASDSSAYASVFHDITSGGNQCTAGSQYCSSTGKSEYTTTTGYDEATGLGSVDFYNLLTSWTSGSSASLEATTTSLSAATATPSAGASDTITITVAPQSSSISSTPTGTVAVVVDGTTETSSLALTNGSATYTFSSTTSGSHVIEATYSGDSIFAGSSGSITVDVGGVNGSTSPGTFTVSASNLTVSQGSSGTSTITVTSQNSYSGTASFSLSTTSASLLEYGCYSIPNVTVSADQTATTTLTIYTSENDCSSSSIRKMQRRSFLRASTVSATTSQPNKPGRGPFPVAFACIAGGVLFVRKRRLRALLSCLLVVGALSLPIACGSRSASSSSSSSSTADEVAKGTYTITLDGVDIADSSIASSTTFALTVD
>NC_012483|3000618:3073984|3018971_3019754_-|WP_015897673.1|DBSCAN-SWA
MSLQSERLLNHMQRLRLSHLPNCYEAIAEEASAKDLPYLDFLEQALEAESQAKHTRNVRLKTQWAHFPYNKGLDQFDFDFQPSVDERKLRELAGLAFLERKENVLLLGPPGVGKTHLAIALGTEAIVAGNTVYFVTVQDLVQQFQRARDENKLKERMTLLVKPKLLILDEMGYLALDPFAATCLFRLVSERYEKGSIIVTSNKSYGDWGTIFADNVIASAILDRLLHHSTTINIKGESYRLKDKKKAGVIAAKTPNREGA
>NC_012483|3000618:3073984|3054897_3056715_+|WP_015897708.1|DBSCAN-SWA
MDSKYIRNFAIIAHIDHGKSTLSDRLLEMTGSLTAREMQAQVLDAMDLERERGITIKAHAVRMLYKAKDGETYQLNLIDTPGHVDFSYEVSRSLASCEGALLIVDASQGVEAQTLANAYLAINNGLEIIPVINKIDLPSADITRTQEMIEQAVGLDATDAIPVSAKTGVGVPDVLEAIVKRLPPPTGDPNAPLQALIFDSWFDAYRGVIVLARVMNGTLRKGMRIRLMSNGKVFDVESMGVLTPKPMEIGELSAGEVGFFVATIKTVSDTKIGDTVTEDARPAAEPLAGFEDIKSMVFAGIYTVDSHEHTLLRDALEKLRLNDSSFFFEPESSVALGFGFRCGFLGLLHMEIIQERLEREFDLDLITTAPGVRYKITMTDGSTLEVDNPSRWPDPSEIEQVEEPVIRATILTNEEYVGGILKLVEEKRGRQQNFEYVTPTRVMLTYELPLNEIVLDFYDRLKSVSRGYASLDYQLAGTWVSPMVKMDILVSGEPVDALSIIVHRDFAYERGRALVSKMRELIPRQQFEVAIQAAIGSKIIARETVAALRKNVIAKCYGGDISRKRKLLEKQKEGKKRMKRIGKVDIPQEAFLAVLKVGEDSASKN
>NC_012483|3000618:3073984|3027115_3027361_+|WP_015897681.1|DBSCAN-SWA
MEVPITKFRHDLFDLVQQAMEGNEVWVRYKGRRFRIAPEGSVGSRISRVTPLQVLNPEASPEEPALLEEMTRAWEKDWSAL
>NC_012483|3000618:3073984|3064835_3065675_-|WP_148215292.1|DBSCAN-SWA
MPSVRTILDQATQRLAGLPTARRDAELLLQHVLGRNRAWLIVHSDDAMTAEQVTQFESWILRRAAQEPVQYIVGEQEFWGLRLRVTPDVLIPRPETEHLVEAALERLPEGETVRVADIGTGSGAIAIALAASRPQALVTALDLSEAALRIARENAAAHGVAERMRFLQSDLLAAVRGERFAMIVSNPPYVPGGEELEPQVRDFEPHSALFAGAEGLDVYRRLIPEAAEVLEPGGWLLMEIGHGQRAALAELLAGWDDIAFVDDLQGIPRVVMARKAIDR
>NC_012483|3000618:3073984|3052723_3054781_-|WP_169305978.1|DBSCAN-SWA
MAVSRILLTGALSGAILLTLTGCPSQQAANTVPRGAVAPATAAPASPDDTAAAATAESTPSDRDQRIIAGVEDQYHSGLDAYQQGNLDTARQHFNRAVDQLLTCGVNLKTDAALRAEFDRIVDSVDTLEMDALKQGNGLTESEPSPVDVANNVTFPVNAKLEAQAAAEIKTTQSDLPLVMNDYVASYINFFENTKRGHDTIVASLERGGRYKGMIEGVLKKAGLPQDLYYQAVAESGFNPTAMNRSSGAGGMWQFMPYGNYGLLHNAWVDQRFDPVLATEAYCRLIKADYDQLGDWYLAMAAYDWGAGNVQRAVERTGYADFWQLYKLNNLPAETKNYVPIILAVTFMAKHPGQYGLNDLSLDPPLTYDTVETHTEINLHLVADITGASVDQLEALNPSLLRGATPPDEAFTLRIPSGTKSSFEQDIALIPPDDRRDWRFHQVQPTDTLASIAHEYHVSEDELASVNQIDAPTDLAQRDAVVIPVARPSQPSLLRTLVYRVRRGDTLVSIADRYGVSVLSLRRWNHLRSSFLRAGQLLHVSTPVRAEMRNTTYARGGTEYHRIGRGETLGGIADHYHVSIEDLRRWNHLHGNEIAAGHSLRVSPPHEHATLADPPAHHSARASHEAAHAAHAAASHPRYYRVRRGDTIGGIAARFHVSITDLRHWNHLRGNEIRAGHSLRVSALR
>NC_012483|3000618:3073984|3050270_3051119_+|WP_015897704.1|DBSCAN-SWA
MSKLGLIAGNGRFPFLLLEAARASGLEVVVAAIKEETDPEMNDRAAADPGLRVYWLSLGELSKLIDTFHKEGVTRAVMAGQVRHKQIFSSIRPDWRLAKLLMSLRTRNTDMLLGAVAKVLGDEGIELISSTTYLEPMLVEPGVLTERAPEEDEQRDIAYGREVAKGIAGYDLGQTVVVAAQACVAVEAMEGTDATIERAGALMRTLDDEASTLSHRLTVVKVAKPKQDMRFDVPVIGLRTIETMIAAGATCLAIEAKRTLIFDRDGVLARANAARIAIIAAE
>NC_012483|3000618:3073984|3029334_3030318_+|WP_041840273.1|DBSCAN-SWA
MEFFTLNGAQVSRIGLGTWAIGGSEWGAVPEADAIATCLAIFDHGINLIDTAPIYGFGRSEQLIGKAIRQHGRRQDFYIATKAGLEWNDRGVFSNSDPARLRQEFEDSLRRLGTDYVDLYQIHWPDTTLPVERAAEVLRQLFDAGRIRAVGVSNFSAAQMDAFSKIVPLHSNQPPYNLFEREIDASTLPYCHSHNIAVLTYSSLCRSLLAGRLKADTPIPEGDIRREDPKFQLPRFAQYLQAVQQLDAFAQQHYGKRVLHLAVRWVLDRPGISAALWGAKRPEQLAPIPEVMGWHLDASAMAEIDRIVAACVTDPVGPEYLTPGVRT
>NC_012483|3000618:3073984|3071774_3072389_+|WP_015897721.1|protease|DBSCAN-SWA
MSTRRNSSLAAPGGDSSFHTSQAARAPRIRSTTVICVRRGNSVVMAADGQVTMGDAVIKQSARKVRRLYQDKVLAGFAGSTADAFSLFGRFEGKLEQHAGNLGRAAVELAKDWRTDKMLRNLEALLIVADPHQMFLIGGAGDVIEPDEGVTAIGSGGSYAMAAARALLENTDLSAREIAEKALRIAGDICIYTNGHITLEELQA
>NC_012483|3000618:3073984|3003788_3004850_-|WP_015897666.1|DBSCAN-SWA
MSAAMKDSPRPFARLVQKVVEDIGTLTREEARVALREMIMGEASTDDISRMLTAISQRGETAEELAGFAEEMRAHAVPLPFTDEERAALVDTCGTGGSGDGTFNISTGAALVAAAAGAKVAKHGNRAVTSKCGSADVLEAMGIPVALTPEQSVECLRATGFAFLYAPALHPALKRVQPIRRALGFRTIFNMAGPLTNPAGARAQVMGVYAANKVVVAAEALSRLGVRHAMVVHGSDGLDELTLTGMSHMVEVRDGLLRRHEFYPSEADLPFCTLDQLQGAATVAANAALIEKILEGETGPRTDIVLLNAAAALVVSGVATSFREGVARCAIAIESGAARQTVEKLRAFGKTIG
>NC_012483|3000618:3073984|3013720_3014374_-|WP_148215144.1|DBSCAN-SWA
MKPSSSKIENAQFSSLDSMLEELRHQTQHEPPPALREYLRIISKQHSNAQKPGALDSRQRAVRVRILALSAAATVACVLLPWLITRLLLPQRDASGIARIASNSAQPVPTHPAASAAKISSSTAPEAVHTETVISAAVANEAGNLIIPLPYSDRAVTTGTISTIPVSVSQNELLTLGVPVSSEEGHHRFVAELILGADGLPRALSVPFPLTTTGDME
>NC_012483|3000618:3073984|3014396_3015185_-|WP_148215145.1|DBSCAN-SWA
MCIERPSQGKLYSVFSKENLSILEVSRVKIAMQDRKRLLLWFQPKTDARAEGRHSDRDSETAAQADISECDNQAFLAIYDRYSRTIYRFLVHMTGSLTIAEDLTQEAFVVILEIMSGEKQLGFDPEKGTLEGYLLGIARNLARRELRKGRRLVSLEGMLDLSIGNETNELLTGNGRISDESLAVVVARAELRSLYRAILELPTHYREVLVLCSLQEKSYKDAATLLQVTEGTIASRMNRAKGLLAAKMRQPSDEKSASSKAQ
>NC_012483|3000618:3073984|3027800_3028217_+|WP_015897683.1|DBSCAN-SWA
MSQRTFSIIKPDAVRKGHTGAILAEIEKAGFKIVAIKKVSISKAQAEGFYYVHKERPFFGSLTDFMSSGPIFPMVLEKDNAIADLRKLMGATNPANAEEGTIRKKFAGSIEENAIHGSDAEETAAFEIGYFFAGCELV
>NC_012483|3000618:3073984|3046626_3047628_+|WP_015897701.1|DBSCAN-SWA
MSQSLLAQLRKMTTVVADTGDIQAIEKVRPQDATTNPSLITAAAGMPAYQKIVDDTLLDAKKQLGDSAPSDKVAKLAFENLAVAFGKQILAIIPGRVSTEVDARLSYDTEATIKQAHAIIEKYQKQGIGRERVLIKIASTWEGIRAAEQLEKEGIHCNLTLLFGMHQAVACAEAGVTLISPFVGRILDWYKKDTGKDYVGADDPGVQSVTRIYNYFKKFGYKTVVMGASFRNTGEIIELAGCDLLTISPKLLEELDAKEAELPRKLDAEKAKGMEIERITVDKATFDKMHAEDRMAHDKLKEGIEGFSEALENLEKLLAKRLEELSAEPVGAK
>NC_012483|3000618:3073984|3033533_3034751_-|WP_015897689.1|DBSCAN-SWA
MLTHSLAFDVKNPPWSEIPAEAGVFALFGADERAEPYLNRTPDLRRRLKRLLDPKPEQSKRLQLAAQIRRIEYTRTGSEFEALLCLYQASVEAMGERARERMHLRAPVFLRMSMQNEFPRVYPATRLTLKAAEDLFGPFPSRWMAERWLEQMLNLFLLRRCQEDLEPDPAFAGCIYSEMRKCLAPCFEGCTRARYDEEAAAVHDFLATRGESLRARLAAEREAASEALDFEKAAEVHARVERVDEVMGALPEAVRPLTQLHGVMVQPSVEPETVALFLLEGGQMAGPALFSTLGMRHPNEQSGSSSLFAHPTMVEPVPLRAEGEPVPAASRDELDRRLEEALAALRERLKKPSSAMLADHLALFKRWFYRPQTKRVGEMVFASPAGEIAGKAVLRAVSRVVRAGM
>NC_012483|3000618:3073984|3066989_3068654_+|WP_148215149.1|DBSCAN-SWA
MPEWNYLNQKAAFSMTRPAPQTSAPFDAFARCNDALAATPGKLARREILVAYLRPLAVPDAARAASSVPPTLTLADVEQAFAQIAAARGPAPRLQRVRQLLACATPLEIKYLIKLMLGDLRTGVKQALVEEAIAQLHEVELPTLRRALMLNGSLPEVVAMAAAHTLPQAQMRLFHPLGFMLASPVAGVEEAMARFASKPDARQASEPPTAIQIEDKYDGIRAQLHCGDPAQPGRVTLFSRNREDIGISFPELIEAFAAMPEPVVLDGEILAWQPASATGAARAMPFAALTQRLGRKRVTAQMRDQIPVVFMAFDLLARHGELLLDQPLSSRRQQLEAFLAAASPLALPAGAAQSSLFAAEESADFLRLKLAPATQLESAAQLDRAYQDARARGNEGVMLKALASPYQPGRRGLAWLKLKRELATLDVVVTGAEFGHGKRAHVLSDYTFAVRDGEELKNIGKAYSGLTDAEIAANTKFLKEHTLEDFGHFRSVEPLLVLEVAFNNIQRSERHNSGFALRFPRIVRIRDDKPVEEIDTLARVEELYQSQPDKPPEA
>NC_012483|3000618:3073984|3035017_3036400_-|WP_015897690.1|DBSCAN-SWA
MSNAAISSTLQELATEMVARALRAGASDAEVSVREGDEFSTTVRMGEVETLKESGSRGIGLRVLVAGENGYRVASSSSSDLTPDGLEHLVRGAMALAQVTSEDPFAGLPEPGSFGQLDGDLELYFDDVYSLPTEERIAYAKRAEAASLAGDARLVNSDGASFDAATGRMAFANSRGFAGEYRSSYCSVVASPIAQGKDGEMQRDYWYSNARSLAKLDSPEEVGRIAAERTLRMLDARRVKTQQAPVVFAPELAGGLVGAIFDAVSGDAVWRGASFLAGKLGETIAVPGLTVVDDGTIPGGFGTRPFDGEGLPTRRNVLVENGVLKSYVLHSYTARKLKMQSTGNAGRGLAGNPYTASHNLFMEAGTTTPEEILRQVGTGFYVTRLMGRGVNMVTGDYSRGAAGLWIENGELAFPVQEVTVAGNLKDMLQNISAMGNDLVFRSSTSAPTLRVDGMTISGRD
>NC_012483|3000618:3073984|3018087_3018414_-|WP_041839553.1|DBSCAN-SWA
MPLLEVTRTRHINAYIRLLDTTATQLDQYAAFLHATADEVIEQALAYIFSKDRDFQEFLKSSEAQTVTPTLRTRKPSPNDSPEQSPRKPASRAANGSTSVDSVAGTRS
>NC_012483|3000618:3073984|3045680_3046472_+|WP_015897700.1|DBSCAN-SWA
MQYCRFLSVVGPQYGAVIPRDGELWIEHLLPAFEEDPTAQPNAASFLPMPLAHARLLAPVAPPKIVCIGRNYRDHAAELGNDVPKEPLLFLKAPSSVIGPGEAIQIPPQSKRVDFEGELAIVIGHRASKIGPDEDVRSYIRGYTIVNDVTARDLQKSDGQWSRAKGFDTFCPAGPIVTSDIDPVAGPGLSVTTTLNGETKQHGHTRDLIFPIPELLRYITAAMTLVPGDVIPTGTPAGVAPMQAGDMVQVTVEGIGSLKNPVA
>NC_012483|3000618:3073984|3008835_3010629_-|WP_169305976.1|DBSCAN-SWA
MPTCNAAAWVGKPLVEPGPAFMANQKIASLDETHQTGARHTSRQNQMRAEKHYLEGVRAFQRHRMKVAEKEFLLAEKLDRSNPRYSLAARMALRFSATPFAREPGTAAHSGQILDALHYASLPHPYSAMATLHPHKKKTKAESSPVIVRQHSSRANAPIKLVALKADCSFHLHATKPSVIRQVLQAYGIQAEIGPDIDDQSVFFDVDSLDFKSAEKALRLATGVLIVPLGVRRALVVANTTKNLRQYDPQIMETITFPGMDRNELEEMENIARNSGGVTRAVLSPDQKVITLRAPGATLMALNHLYRELLDDTSEVRLDIHVYEVDRTGENDTGAILPNSVTLFNLNSEADSVLAENASLVQEIISSGLAKAGDWETIIGILLAAGDISGTDFNNPFVIFGGGITETGAEWNTTAANMLLTSSNVISLDQVQLSVRDQKEATFLDGERYPIMTGKLSNLGNLGESTGTSPQFQYVNLGLTLKVTPSIQANKNVTLHMKLQLSGLAGTTLDDIPVLTNRQYSGEVSIHAGYSALIVSSMSKQNNLDLTGMPGLSEIPDLHDMTNRDTSSSDQELVILVTPHIIRLGHPGISGPVIPLE
>NC_012483|3000618:3073984|3063445_3064711_-|WP_015897714.1|DBSCAN-SWA
MSVAAVTPEKTLTFEQKLDRLADVAVRVGLGLKEGQELVLTASVDTLPLVRRITAHAYEAGASLVTTLLSDEASTLLRYRHGKDASFDKAAGWLYEGMAAAYASGAARMAVAGANPALLSKEDPEKVGRANRSNSIAYRPALELITKHAINWTIVPAATPDWAKLVFPDLPADQALARLWDAIFAATRVDREDPVAAWKEHDAKLHQRADYLNKKRYHALHFRGPGTDLTVGLADDHLWLGGGTQAHNGQYCIPNLPTEEVFTTPHKDRVNGTVTSTKPLSHQGTLIEKISVRFENGRIVEAHAAAGEAVLQRMIETDAGARMLGEVALVPHSSPISASGVLFWNTLFDENAACHIALGQAYSTCVKNGENMKPEELAAKGANESLIHVDWMIGSGEVSVDGVNADGSHEPLMVKGEFVTA
>NC_012483|3000618:3073984|3027357_3027738_+|WP_015897682.1|DBSCAN-SWA
MIAYLDTNVVVWLAQGDLSRISAPALAVLEEADLRISPMVLIELEYLHEVRRILLSSREILLKIEHELGVEVCNLSFPRVAQVVLDEKWTRDPFDRTIVAHAKANGLASLVTADEEIRKHYPKAVW
>NC_012483|3000618:3073984|3031640_3032570_-|WP_148215146.1|DBSCAN-SWA
MARLVGMTPKPSSKSSRKPVKAGARAAKSAQKKAARPAAKKTASAAGKTTAKTATKAATKATTKTEAKAAAKKTAKPRAAAAKPKVKAGGKASQKKAAASAGFAPQQERSQETHRKLMHAAIKVVSKQGLQSATIPKIAEAAGVSAANVYRRFEDKDALLQAAFLDMLEHAARTNREELTAEKLEGIPFAQALPAMMAAMYSQNRQTQAARRALRQFLEQSEDKAFQKQAANLIADSYMLLVDLLMVYRNEIRHPEPEKALRFAMMQAGTAFETITLAGESVWERVLEMDDDAVFQEMLRSLAAYLMVR
>NC_012483|3000618:3073984|3071051_3071537_-|WP_148215293.1|DBSCAN-SWA
MPVYNLRDPQVYGTAAVFALFAAGAGAWLMLRKRPTADDLERMRREDLVRMGRLIDGTVLDVSDLTEEESGRKGGMQLILYKYEIAGVVYECSQDVSTLSEYLDIHQMRLGFPCSVRYDTHRPTNSIVVAETWSGLRDIASGVPVRRGIPPQRTPRTTTSA
>NC_012483|3000618:3073984|3057739_3058483_-|WP_015897710.1|DBSCAN-SWA
MLSTSLFVILIVLLATGVRSTFGFGESLLAVPLLAFCMPVQTAAPLAVLLSITVATVILIQDWKKIHFGSALSWLVATCFGIPLGLMLLTSGHEGAVKIALALLLMGFALFSLTGLQRWQIRRDHRPLLLGCGLLAGVLGGAYGMNSPPLVIYGALRRWPAPQFRATLQGYFLPASALCMLGYWRAGLWTHTVTHYYLISLPVLLPVIPLGRWVNRRMHPERFLKYVYVGLMVIGVILLAQTVHAAG
>NC_012483|3000618:3073984|3058565_3059477_-|WP_015897711.1|DBSCAN-SWA
MAHPAALSHPAERANTHEPVRGRTTVGDFELTVVSDGHYFLDGGAMFGVVPKPMWEKRAPADAQNRILLGTNTVIVRTGQHTVAIETGLGNKMSEKMRAIFEAKEQLPRALEAAGVRPEEVDVVINTHLHFDHCGWNTTKLPDGRIVPTFPNARYFAHRGEVAHGHLQLERDAVSYNSPNYDPLVESGQMTLLDTRPNEVTEIVPGISVECYPGHTSQLLAVNIDSAGQRGCYISDLIPTSAHLDITWVMGYDLDPLTCIEQRKRFYKRAIPEQWLVLFTHDHHVPFGHVKLNEKSKPVMRQG
>NC_012483|3000618:3073984|3062064_3063327_-|WP_015897713.1|DBSCAN-SWA
MAIDTHRSFESTLASARSTMGLGEIVRLAVDSFRASKMRFALTALGMVIGSMSLILVVTIGLTGKHFIIHELQSIGTNMIDLEYAGGGGGTVSNYRTDYLRLDDMRAVEEQLPEIAAASPLLQMHDRIDVGSGVEKDILVLGVTPPYRKIRNLIVPTGRFFDDEDEVTHAQVADITLPLAKLMFGSPQNAINKTFTISGIPFTIIGTFKESVDTFGESEIRDETILIPYSVARYFTGTDYVQDIFFSTRDQSDIEQTAQQIVKIVKSRHQPNSVYTATTLTSLITTAGIIANALTIILLLVAAVTLAVGGVGIMNIMLATVRSRIREIGIRKALGATAREIKLQFLIEAIFISLAGGLVGTLIGISLPLSVRLFTSYKLPISGISILVALGTSVAVGVVFGTLPANRAAQMDPVESLKYE
>NC_012483|3000618:3073984|3026129_3027005_+|WP_015897680.1|DBSCAN-SWA
MAVLVNKETRLIVQGITGKEGTFHAKGCAEYGTKVVGGVTPGKGGTTHEGWPVFDTVQKAVEETGANATVIFVPPPFAADAILEANEAGLPLIICITEGIPVNDMVKVWSVLKHSKSTLVGPNCPGVISPGKAKIGIMPGRIHKEGNVGIVSRSGTLTYEAVYQLTQRGIGQSTAIGIGGDPIIGTTHVDALKLLNEDSETEAIILIGEIGGTAEETAAEYVRNHVKKPVVGFIAGQTAPPGRRMGHAGAIISGGQGTAAEKMKALTAAGIHVVQSPAEIGETVARVIGKA
>NC_012483|3000618:3073984|3012773_3013724_-|WP_015897670.1|DBSCAN-SWA
MNWKLCCCLTLVTCYGVYAAGAVHADLINGHEINGQLIAGMQVGPPPGLGGPFEGPERTAVVRNEPYQAEAITEIRQTLADGTHIRQTITATVARDKQGRTVRVERLGWNGAFFVFRAGGNGSTADVHAQPPILTSIFDPVSHEHIVFTSDVKVAHVSPIGVLPGKPIFRNASPGAASRATQQLSVHHIPGAADMGGPSFRLEFAGGCDGCDTETKTLGSRTVDGVKAIGTRRTWTIPVSAIGNDRPIVTTEDTWYSPKLQLVLLSMRRDARFGNTTYMIKGLRLENPKESLFRIPAGYTLQRLDTPPRPFDPTDF
>NC_012483|3000618:3073984|3070003_3070981_-|WP_015897719.1|DBSCAN-SWA
MHVHAAPTKKTQRVLQFSVAATLGYVGLTLFAGWRAHSLALISEAGHNASDALALVLSFVAVYFQMRPANPRKTFGYHRAGVLAAFLNALALMVISVWIAWEAVARFQHPAGVHPKIMMAVAAAGVLMNGVIATLLWRVSHDVNMRSVYIHMLGDTLSTAAVIVGGVVIFFTGMTWVDPALSLGIAAMIFWSSLGIVRETLNILLEGTPRGLRLEEIRTRLCTIDGVEDVHDLHVWSLGSNSHALATHVTIPDIPPSESQLILENIRCMLRDKFHIQHTTVQFENAPCEVSHGCASPLEVSDAGHGHHHGHSHGHAHDHEHGHVH
>NC_012483|3000618:3073984|3049486_3050263_+|WP_015897703.1|DBSCAN-SWA
MSIHPTAIVAEGAVVPASCTVGPYCTIGPNVVLGEDCELASHVVLDGHLTAGARNKFYSFACVGIAPQDLKYKGEPTAVVLGDDNTIREYVTISRGTPGGGGATRVGSGCLIMAYTHIGHDSVIGNGCILANAATLAGHVIVEDYATVGALCPVHQFCRIGRYAYIGGGTTITQDVLPFSLTSAKRETHAYGLNKVGLERRGFDRPRLRAIQHAYRLLLAAKMNTTQAIAKLREEGIATEDVAYLVEFIEQSERGVLK
>NC_012483|3000618:3073984|3043493_3044414_+|WP_015897698.1|DBSCAN-SWA
MKPQVLLSGASGLIGTALREILAQEGYGCKQLVRRPARTSEELEWNPQSGKTPDCNRLSGTEIAIHLSGANISSTRWTDARKRVLVQSRVEPVRALAAALCQTEPRPKVLVCASAIGIYGERGDEVVDENSAPGQGFLPETCLAWEAAAAEAAACGIRVVSARFGIVLSPRGGALAKMLPLFRLGLGGPLGNGREWMSWISLEDTARALIFLGQRAIDDPSAPLVEAVNVVAPNPVRNADFTRQLGHVLHRPAILPAPAFALRLVFGEMADQALLASTRVAPTRLQQNGFEFHHPALAEALRHELQ
>NC_012483|3000618:3073984|3024525_3025701_+|WP_015897678.1|DBSCAN-SWA
MKIHEYQAKDILAKYGVAVPRGEVANTLEEAMDVAKRLFAEGAKGVVVKAQIHAGGRGKGGGVKVAKTLEEAEQYAKQILGMQLVTHQTGPQGQKVQRLLIEETAAIDRELYLGIVLDRAAAKLVFMASQAGGMEIEEVAAKDPSAIFKAYIDPAVGFQAYQARQLAFALGLKPTQINDAVKFMMGLYKAYMDTDASLLEINPFITTKDDKLFALDCKINFDDNAMFRHKDLKELRDIAEEDPLEVEASKYALNYIKLDGNIACMVNGAGLAMATMDIIQYAGGMPANFLDVGGGANQQQIEHAFEILLSDKNVQAVFINIFGGILRVDTLAHGVVGAAQKLNVKVPIVLRLEGTNVEEGRKILKDSGLNFIVGDTMQDAAQKVVAAAKGQ
>NC_012483|3000618:3073984|3039428_3040493_-|WP_041839555.1|DBSCAN-SWA
MHPERKQSDAAPVRGRIALVYALLVLFNGAAWLWAVAAFHRYPLLLGTAFLAYSFGLRHAVDADHIAAIDNVTRKLMQEGQRPVGVGLLFSLGHSTVVVTGSLAMAAVTLGVQSHVAAHMRWIESVGSVVGTLVSSLFLLGIAAANWMVLRGVYASFQKVRRGEPYVEEDLSLLLAGRGFLARIFRPIFGRIRASWHMYPLGVLFGLGFDTATEIGLLGISAAEASHGLPLRSILVFPALFAAGMSLVDTTDNVLMLGAYGWAYVKPIRKLYYNLTITAVSVAVAVGVGGIEALGLLGGQLHLRGWFWRGIDGLNNHFGLLGYGIIALFALSWMVSIAVYKVGRFEELEWKAEG
>NC_012483|3000618:3073984|3038936_3039365_+|WP_015897694.1|DBSCAN-SWA
MTERKRLVLDANILLRAAFGVRVRSLLEAYEDAVLFFTPDVCISDARQYIPALASKRGIDAAPGLAVLDKLAGLIEIVNSSLYESYETQARERMQSRDMEDWPIVAASLLLQCPIWTEDQDFFGSGVSIWTTRTIEVYLRDA
>NC_012483|3000618:3073984|3040559_3042374_-|WP_148215147.1|DBSCAN-SWA
MSTIRNIAIIAHVDHGKTTLVDAMLRQAGTFRANEAVTDRVMDSNDLERERGITILAKNTAIQYKGDKVNIVDTPGHADFGGEVERALKMVDGVMLLVDASEGPLPQTRYVLSKALAGRLPVILVINKIDRPDARPQEVLNEVYDLFIDLDATEDQLEFPVLYTNGKQGTASTDAATPGTDLQPLFEQIVTTIPPATGDANGALQVLVTNLDYSDYLGRLAVARVFNGTLKTGDEVFISKRDGSLQKTKITKLFSFSGLKRVDIESTEIGDIVAVAGVEGITIGETITGIENPAPLPLIVIDEPTIAMQFMVNNSPMAGREGQYVTSRNLRERLDKELLTNVSIRVEETDSPDSFKVLGRGELQLAILIEMMRREGFELMVGRPEIVTRVVDGKTMEPVEYLTIDVPENFVGTVIERLGPRKGEMAKMHNHGSGRVRMEFKVPSRGLIGLRSEMLTETRGTIVMNSIFDGYMPYQGEIPQRPTGALIADRAGTTTAYALDGLQDRGILFLPAGVEVYEGMIIGEHSRDNDLDVNVVREKKLTNMRASSADDAVRLTPPRLLNLENSIEFIADDEMVEVTPKSLRLRKKVLQANRRPRRNAQPSA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015897662.1|3000618_3001320_-|protease	site-2 protease family protein	NA	NA	NA	NA
WP_083770683.1|3001369_3001657_-	cupin domain-containing protein	NA	NA	NA	NA
WP_015897665.1|3002754_3003501_-	SIMPL domain-containing protein	NA	NA	NA	NA
WP_015897666.1|3003788_3004850_-	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	1.8e-50	37.2
WP_169305975.1|3005235_3005553_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_148215143.1|3005682_3008664_+	Ig-like domain repeat protein	NA	NA	NA	NA
WP_169305976.1|3008835_3010629_-	hypothetical protein	NA	NA	NA	NA
WP_083770605.1|3010691_3012623_-	type II secretion system protein GspD	NA	NA	NA	NA
WP_015897670.1|3012773_3013724_-	hypothetical protein	NA	NA	NA	NA
WP_148215144.1|3013720_3014374_-	hypothetical protein	NA	NA	NA	NA
WP_148215145.1|3014396_3015185_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_041839553.1|3018087_3018414_-	hypothetical protein	NA	NA	NA	NA
WP_015897673.1|3018971_3019754_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	4.1e-68	52.7
WP_169305977.1|3019737_3020703_-|transposase	IS21 family transposase	NA	NA	NA	NA
WP_052294804.1|3020739_3020985_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_083770606.1|3021135_3022041_+	RNA-directed DNA polymerase	NA	NA	NA	NA
WP_015897678.1|3024525_3025701_+	ADP-forming succinate--CoA ligase subunit beta	NA	NA	NA	NA
WP_015897680.1|3026129_3027005_+	succinate--CoA ligase subunit alpha	NA	NA	NA	NA
WP_015897681.1|3027115_3027361_+	hypothetical protein	NA	NA	NA	NA
WP_015897682.1|3027357_3027738_+	PIN domain-containing protein	NA	NA	NA	NA
WP_015897683.1|3027800_3028217_+	nucleoside-diphosphate kinase	NA	NA	NA	NA
WP_015897684.1|3028351_3029143_+	DUF3050 domain-containing protein	NA	NA	NA	NA
WP_041840273.1|3029334_3030318_+	aldo/keto reductase	NA	NA	NA	NA
WP_012680514.1|3030570_3031503_-|transposase	IS481-like element ISAcp2 family transposase	NA	NA	NA	NA
WP_148215146.1|3031640_3032570_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_015897689.1|3033533_3034751_-	excinuclease ABC subunit C	NA	NA	NA	NA
WP_015897690.1|3035017_3036400_-	peptidase	NA	NA	NA	NA
WP_015897691.1|3036396_3037824_-|protease	metalloprotease TldD	NA	NA	NA	NA
WP_041839554.1|3038001_3038535_+	putative metal-dependent hydrolase	D0R7I3	Paenibacillus_phage	2.5e-16	41.4
WP_015897693.1|3038676_3038940_+	prevent-host-death protein	NA	NA	NA	NA
WP_015897694.1|3038936_3039365_+	hypothetical protein	NA	NA	NA	NA
WP_041839555.1|3039428_3040493_-	HoxN/HupN/NixA family nickel/cobalt transporter	NA	NA	NA	NA
WP_148215147.1|3040559_3042374_-	translational GTPase TypA	NA	NA	NA	NA
WP_015897697.1|3042575_3043358_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_015897698.1|3043493_3044414_+	TIGR01777 family protein	NA	NA	NA	NA
WP_015897699.1|3044443_3045577_+	fibronectin type III domain-containing protein	NA	NA	NA	NA
WP_015897700.1|3045680_3046472_+	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_015897701.1|3046626_3047628_+	transaldolase	E3SQJ7	Cyanophage	1.9e-12	36.2
WP_041839556.1|3047720_3048431_-	DUF3800 domain-containing protein	NA	NA	NA	NA
WP_015897702.1|3048929_3049490_+	3-hydroxyacyl-ACP dehydratase FabZ	NA	NA	NA	NA
WP_015897703.1|3049486_3050263_+	acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase	NA	NA	NA	NA
WP_015897704.1|3050270_3051119_+	UDP-2,3-diacylglucosamine diphosphatase LpxI	NA	NA	NA	NA
WP_015897705.1|3051182_3051731_+	peroxiredoxin	NA	NA	NA	NA
WP_085947585.1|3051816_3052386_-	histone	NA	NA	NA	NA
WP_169305978.1|3052723_3054781_-	LysM peptidoglycan-binding domain-containing protein	I1VXB7	Halocynthia_phage	1.6e-05	30.6
WP_015897708.1|3054897_3056715_+	elongation factor 4	A0A2K9L2P9	Tupanvirus	2.0e-20	42.2
WP_015897709.1|3056749_3057682_-	alpha/beta hydrolase	M1PGN2	Moumouvirus	1.1e-32	30.3
WP_015897710.1|3057739_3058483_-	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_015897711.1|3058565_3059477_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_015897712.1|3059480_3061739_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_015897713.1|3062064_3063327_-	ABC transporter permease	NA	NA	NA	NA
WP_015897714.1|3063445_3064711_-	aminopeptidase	NA	NA	NA	NA
WP_148215292.1|3064835_3065675_-	peptide chain release factor N(5)-glutamine methyltransferase	NA	NA	NA	NA
WP_015897716.1|3065750_3066827_-	peptide chain release factor 1	NA	NA	NA	NA
WP_148215149.1|3066989_3068654_+	ATP-dependent DNA ligase	G4YDI7	Emiliania_huxleyi_virus	1.4e-28	26.2
WP_015897718.1|3068905_3069940_-	nucleoside hydrolase	NA	NA	NA	NA
WP_015897719.1|3070003_3070981_-	cation transporter	A0A1V0SED0	Indivirus	7.4e-06	32.5
WP_148215293.1|3071051_3071537_-	hypothetical protein	NA	NA	NA	NA
WP_015897721.1|3071774_3072389_+|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_015897722.1|3072412_3073984_+|protease	ATP-dependent protease ATPase subunit HslU	A0A191ZC11	Erwinia_phage	4.6e-42	29.3