CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_012668	Vibrio cholerae MJ-1236 chromosome 1, complete sequence	1 crisprs	DEDDh,cas3,RT,DinG,csx1,WYL,csa3	0	1	4	0
NC_012667	Vibrio cholerae MJ-1236 chromosome 2, complete sequence	1 crisprs	cas3,csa3	0	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_012668_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012668_1

138888-139131

Orphan

Consensus_repeat	Method
AAAATGTGCCTCCTTAGCTCAGTCGGTAGAGCAACGGACTGATAATCCG	PILER-CR

2 spacers

The CRISPR arrays of NC_012668_1

>merge|NC_012668|1|138888-139131|PILER-CR
TGTGCCGGCTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGGTCGCCAGTTCGATTCCGGCAGCCGGCACCACTTAAAATTTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCTCGTGTCGGTGGTTCGATTCCGCCTCGAGGCACCACTATTAAAAGTTGTGCCATAGACACAATAAAAATTGTTCCTCCTTAGCTCAGTCGGTAGAGCGACGGACTGTTAATCCG

>NC_012668|1|1|138888-139131|PILER-CR
TGTGCCGGCTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGG	TCGCCAGTTCGATTCCGGCAGCCGGCACCACTTAAAA
TTTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCTCGTG	TCGGTGGTTCGATTCCGCCTCGAGGCACCACTATTAAAAGTTGTGCCATAGACACAATAAAAAT
TGTTCCTCCTTAGCTCAGTCGGTAGAGCGACGGACTGTTAATCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012668.1\|WP_001230176.1\|137529_138657_+\|membrane-bound-lytic-murein-transglycosylase-MltC	unknown	unknown	gnl\|CDD\|183271
NC_012668.1\|WP_000973535.1\|150036_150534_-\|type-3-dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NC_012668.1\|WP_000718491.1\|131261_131552_+\|YggU-family-protein	unknown	unknown	gnl\|CDD\|179931
NC_012668.1\|WP_001233674.1\|131597_132029_+\|DUF4426-domain-containing-protein	unknown	unknown	gnl\|CDD\|379616
NC_012668.1\|WP_000546924.1\|142092_142947_-\|co-chaperone-DjlA	unknown	unknown	gnl\|CDD\|236512
NC_012668.1\|WP_000805043.1\|134090_135011_-\|glutaminase-B	unknown	unknown	gnl\|CDD\|234880
NC_012668.1\|WP_000957351.1\|132694_133870_+\|radical-SAM-family-heme-chaperone-HemW	unknown	unknown	gnl\|CDD\|235550
NC_012668.1\|WP_001883271.1\|143093_145457_+\|LPS-assembly-protein-LptD	unknown	unknown	gnl\|CDD\|235158
NC_012668.1\|WP_001892423.1\|150546_151032_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182143
NC_012668.1\|WP_000780524.1\|145509_146805_+\|peptidylprolyl-isomerase-SurA	unknown	unknown	gnl\|CDD\|236758
NC_012668.1\|WP_000725019.1\|132098_132701_+\|XTP/dITP-diphosphatase	unknown	unknown	gnl\|CDD\|234648
NC_012668.1\|WP_001890075.1\|136080_137142_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|182805
NC_012668.1\|WP_000124738.1\|137155_137428_+\|oxidative-damage-protection-protein	unknown	unknown	gnl\|CDD\|180059
NC_012668.1\|WP_000035032.1\|149078_149888_+\|symmetrical-bis(5'-nucleosyl)-tetraphosphatase	unknown	unknown	gnl\|CDD\|234673
NC_012668.1\|WP_000095773.1\|146794_147787_+\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	unknown	unknown	gnl\|CDD\|234696
NC_012668.1\|WP_001243262.1\|147800_148616_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NC_012668.1\|WP_000005584.1\|135121_135841_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NC_012668.1\|WP_000769920.1\|139420_141046_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NC_012668.1\|WP_000383338.1\|148687_149068_+\|Co2+/Mg2+-efflux-protein-ApaG	unknown	unknown	gnl\|CDD\|180098
NC_012668.1\|WP_001087263.1\|130704_131262_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|223833

Protein	Function_ID	Function_description	E-value
NC_012668.1\|WP_001230176.1\|137529_138657_+\|membrane-bound-lytic-murein-transglycosylase-MltC	gnl\|CDD\|183271	PRK11671, mltC, membrane-bound lytic murein transglycosylase MltC.	9.42926e-157
NC_012668.1\|WP_000973535.1\|150036_150534_-\|type-3-dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	1.40644e-92
NC_012668.1\|WP_000718491.1\|131261_131552_+\|YggU-family-protein	gnl\|CDD\|179931	PRK05090, PRK05090, hypothetical protein; Validated.	2.12816e-59
NC_012668.1\|WP_001233674.1\|131597_132029_+\|DUF4426-domain-containing-protein	gnl\|CDD\|379616	pfam14467, DUF4426, Domain of unknown function (DUF4426). Members of this entry are found mostly in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine biosynthesis protein MetW. On the other hand, in most Vibrio species it appears as a part of a conserved operon involved in possible response to stress.	6.80534e-67
NC_012668.1\|WP_000546924.1\|142092_142947_-\|co-chaperone-DjlA	gnl\|CDD\|236512	PRK09430, djlA, co-chaperone DjlA.	1.60415e-153
NC_012668.1\|WP_000805043.1\|134090_135011_-\|glutaminase-B	gnl\|CDD\|234880	PRK00971, PRK00971, glutaminase; Provisional.	0
NC_012668.1\|WP_000957351.1\|132694_133870_+\|radical-SAM-family-heme-chaperone-HemW	gnl\|CDD\|235550	PRK05660, PRK05660, radical SAM family heme chaperone HemW.	0
NC_012668.1\|WP_001883271.1\|143093_145457_+\|LPS-assembly-protein-LptD	gnl\|CDD\|235158	PRK03761, PRK03761, LPS assembly outer membrane complex protein LptD; Provisional.	0
NC_012668.1\|WP_001892423.1\|150546_151032_-\|hypothetical-protein	gnl\|CDD\|182143	PRK09917, PRK09917, threonine/serine exporter.	2.57871e-66
NC_012668.1\|WP_000780524.1\|145509_146805_+\|peptidylprolyl-isomerase-SurA	gnl\|CDD\|236758	PRK10770, PRK10770, peptidyl-prolyl cis-trans isomerase SurA; Provisional.	9.94454e-157
NC_012668.1\|WP_000725019.1\|132098_132701_+\|XTP/dITP-diphosphatase	gnl\|CDD\|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	4.099e-127
NC_012668.1\|WP_001890075.1\|136080_137142_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|182805	PRK10880, PRK10880, adenine DNA glycosylase.	0
NC_012668.1\|WP_000124738.1\|137155_137428_+\|oxidative-damage-protection-protein	gnl\|CDD\|180059	PRK05408, PRK05408, oxidative damage protection protein; Provisional.	5.47988e-59
NC_012668.1\|WP_000035032.1\|149078_149888_+\|symmetrical-bis(5'-nucleosyl)-tetraphosphatase	gnl\|CDD\|234673	PRK00166, apaH, symmetrical bis(5'-nucleosyl)-tetraphosphatase.	1.41419e-169
NC_012668.1\|WP_000095773.1\|146794_147787_+\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	gnl\|CDD\|234696	PRK00232, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed.	0
NC_012668.1\|WP_001243262.1\|147800_148616_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	3.27746e-146
NC_012668.1\|WP_000005584.1\|135121_135841_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	6.01203e-111
NC_012668.1\|WP_000769920.1\|139420_141046_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	2.35326e-58
NC_012668.1\|WP_000383338.1\|148687_149068_+\|Co2+/Mg2+-efflux-protein-ApaG	gnl\|CDD\|180098	PRK05461, apaG, CO2+/MG2+ efflux protein ApaG; Reviewed.	1.16069e-74
NC_012668.1\|WP_001087263.1\|130704_131262_+\|YggT-family-protein	gnl\|CDD\|223833	COG0762, COG0762, Predicted integral membrane protein [Function unknown].	1.96316e-12

>NC_012668.1|WP_001230176.1|137529_138657_+|membrane-bound-lytic-murein-transglycosylase-MltC
MRKLVLCITALLLSGCSREFIEKIYDVDYEPTNRFAKNLAELPGQFQKDTAALDALINSFSGNIEKRWGRRELKIAGKNNYVKYIDNYLSRSEVNFTEGRIIVETVSPIDPKAHLRNAIITTLLTPDDPAHVDLFSSKDIELKGQPFLYQQVLDQDGQPIQWSWRANRYADYLIANHLKVKQVDFKKAYYVEIPMVKDQIDIRGYKYASIVRKASRKYDIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLVKNRSGEPSPEYLFNPENNIDTGTAYFYILKNRYLKEVRHPTSLEYSMISAYNGGTGGVLSTFSSDRQRAMRDLNALQPNQVYWALTKKHPNAEARRYLEKVTKFKKEFNAG
>NC_012668.1|WP_000124738.1|137155_137428_+|oxidative-damage-protection-protein
MARTVFCTRLQKEADGLDFQLYPGELGKRIFDNICKEAWAQWQTKQTMLINEKKLNMMDPEHRKLLEQEMVNFLFEGKEVHIEGYTPPAK
>NC_012668.1|WP_001890075.1|136080_137142_+|A/G-specific-adenine-glycosylase
MTPFAQAILTWYDAYGRKNLPWQQNKNAYRVWLSEIMLQQTQVATVIPYFERFLERFPTVHALAAAPQDEVLHFWTGLGYYARARNLHKAAQMVVSEYGGEFPTDLEQMNALPGVGRSTAAAVLSSVYKKPHAILDGNVKRTLARCFAVEGWPGQKSVENQLWHYAEMHTPKVDVDKYNQAMMDMGAMICTRSKPKCSLCPVESFCLAKQQGNPQEYPGKKPKTDKPVKATWFVMLYHDNAVWLEQRPQSGIWGGLYCFPQSEIANIQTTIDQRAIGDSTITSQKTLIAFRHTFSHYHLDITPILLQLSRKPDIVMEGSKGLWYNLSHPDEIGLAAPVKQLLHTLPFDIDSHI
>NC_012668.1|WP_000005584.1|135121_135841_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MSEVITQEYTEDGKVLRRIRSFVRREGRLTKGQEAAMKECWPTMGIDYQPELLDWQQVFGNDNPVVLEIGFGMGASLVEMAKNAPEKNFLGIEVHSPGVGACLASAREAGVTNLRVMCHDAVEVFAHMIPDNSLHTLQLFFPDPWHKKRHHKRRIVQLEFAEMVRQKLMIGSGVFHMATDWENYAEHMVEVMNQAPGFANLATDGDYVPRPDERPLTKFEQRGHRLGHGVWDIKYQRTA
>NC_012668.1|WP_000805043.1|134090_135011_-|glutaminase-B
MKPTADILASIIEEVRPLTSKGIVADYIPALAKVPSDKLGIAVFTNQGEVITAGDAQEGFSIQSISKVLSLTLAMGLYQPDELWSRVGKEPSGQAFNSLIQLEMEQGIPRNPFINAGAIVVCDMLQSRLSAPRQRLLEFVRQLSGEPQIAYDKVVAASEMMHSDRNAAIAYLMRSFGNFHNEVIPVLHNYFHACALKMSCVELAKTFSYLANKGVSVVTGETVITPTQSKQTNALLATCGLYDGAGEFAYRVGMPGKSGVGGGIIAVVPGEMTIAVWSPALDQSGNSLAGTRALELLAQRIGRSIF
>NC_012668.1|WP_000957351.1|132694_133870_+|radical-SAM-family-heme-chaperone-HemW
MLTPPSLSLYIHIPWCVQKCPYCDFNSHAQKGEIPEQEYLDALLQDLDRDIERYQLKGDPRLLHSIFIGGGTPSLISAEGIARLLQGVAERIAFKPEIEITMEANPGTIEAQRFAGYRTAGVTRISIGVQSFEPEKLARLGRIHGQQEAVRAAQLAHQIGLNSFNLDLMHGLPDQTPEQALADLDQAIALNPPHLSWYQLTIEPNTLFYSKPPKLPDEDALWDIFELGHQKLSDAGYVQYEISGYSKPGYQCQHNLNYWRFGDYLGIGCGAHGKLSFADGRIVRTTKTKHPRGYLAALNNLAKAYLDSEQLVADQDKPFEFFMNRFRLIEPCPKADFTATTGLTIDVIRPTLDWALSEGYLSEDDQHWQITEKGKLFLNDLLEAFMADEEE
>NC_012668.1|WP_000725019.1|132098_132701_+|XTP/dITP-diphosphatase
MKKIVLATGNQGKVREMADLLSDFGFDVVAQSEFNVPEAAETGTTFIENAIIKARHAAQITGLPTIADDSGLEVDYLNGAPGIYSARYAGEHASDGDNLNKLLMAMQDVPDDQRSARFHCVLVLMRHADDPTPIVCHGKWEGKILTAPHGSNGFGYDPIFWVPEENCASAELEPVRKKQLSHRGKALQKLFKAIEEQRTC
>NC_012668.1|WP_001233674.1|131597_132029_+|DUF4426-domain-containing-protein
MRKWMMSLLLTLLALPASAEQQKTIKDIEVHYSAFNSTFLTPKVASSYQLTRNGYTAILNISVLDRASLGKPATEAKLTGHAKNLIGNLRELSFKQVKEGNAIYYLAEVPISNEEMLTFDIDVDAGLKGAGKLTFSQKFYTEQ
>NC_012668.1|WP_000718491.1|131261_131552_+|YggU-family-protein
MAAAWREGDDLLLRLYIQPKASRDSIVGLHGEELKVAITAPPIDGKANAHLSKYLAKLCKVAKGSVVVEKGELGRHKQVRILQPSQIPAEIAALIE
>NC_012668.1|WP_001087263.1|130704_131262_+|YggT-family-protein
MNSLSFLINTLFDLYIMVVILRIWLQAARADFYNPFSQFIVKATQPVVGPLRRVIPSIGSIDLATIVFAYVLCVLKFMALVLIASSGSVSFSADFLFLGLLSLIKAAGGLLFWVLLIRAILSWVSQGRSPIEYVFHQLTEPMLAPIRRIIPVMGGFDLSVLVLFIVLQFANFLMGDVIGPIWYQL
>NC_012668.1|WP_000769920.1|139420_141046_+|methyl-accepting-chemotaxis-protein
MKLKTQAYLLSAIILAALLALTATGLWTLRVASNLDNKARVTELFNSAYSILTEVEKLAQEGKMSEPEAKALATRLMRNNLYKDNEYVYVADENMTFVATPLDPQLHDTSFHDFKDGKGNSVGRLIQDVLRHQSGKLVEYTWTQKQADGSIEEKLSIARKTPHWGWVVGTGIGFNEVNARFWSTAQWQLSLCVVIAVAILSLLLVAIRKILLIIGGEPNEVRSAVQAVAQGRIRREFVIKAPKESIYGAVQQMSSSLADLVAKLEQSMVALRSELAGAGTRAKSIAELTDSQQQSTAMIATAMTEMASSANQVADSARDTAFNTDQADQQSQHTQKLIHNTVSNIQGLATQLQTASTAVADLDLDVKNIAKVLDVIGDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRNLAGRTQTSTKEIQQMIHNLQEGSRNAIQTIQICGQTSQSSVQESENAASALALIVSALESVSSMSHQIATAAAEQTQVSDDIARRINMIEESGSKLSRVVMESHNSTQTLTKLARELEQWAAHFEVTR
>NC_012668.1|WP_000546924.1|142092_142947_-|co-chaperone-DjlA
MHIFGKILGAFFGFLFGGPFGAIFGIFLGHQFDKARRLNQAGFQSGTFGAGPSQAERQEEFFKSAFSVMGHVAKAKGQVTKEEIQLATIMMDRMNLTLEQKRAAQDAFRDGKESDFPLEQVLERVKIATGGRFDLLQFFLELQVSSAFADGDVHPSERQVLHRIARGLGFSSEQLERRLRMQEAAFRFQQGGGFGGSQQQSHSGQQWQQPSSRHQLADAYEVLGVSESASAQEVKRAYRKLMNEHHPDKLMAKGLPPEMMNVAKEKSQQIQHAYELIRKEKGIK
>NC_012668.1|WP_001883271.1|143093_145457_+|LPS-assembly-protein-LptD
MYNPMSCFSRTFLAASISAALFAPQIQAEASVDDNRAQLPNGEQCLVNQPEPTNPGQQPINVEADKLEAINGQKATYSGNVVVVQGKKRIAADNVTLHQQENVVVAEGNVQFSDGEIKTHSTKATNHLNTDEMTLENTRYQFLCEPGRGEAVYVSKTGKAVYEIEDGSITSCPDGDNAWRMRASSIDVDQNEEIATFYNPRLEVQNVPVFYLPYLTVPIGDTRKTGFLYPTASYGSRNGYSFEVPIYWNLAPQYDLETTFNYMQKRGTQLNSVFRYLTDFGAGQIKSEYLADDQLHTELGDRWAFQYEHNGIFQQAWKFEIDYSKVSDINYFSDLDSGVGNREDGQLIQEGRATYRSDNWDSALLVRDFQLLTKDTTSTNLPYRLMPQLSYNYYAPETMKYLDLDLVSHVSRFETDARGKPSATRVHIEPGLKIPFSNTWGNWTTEARVLGTYYQQDLDKTTDAKLEESVTRVIPEIRSVAGIVLERDTVLLDDYTQTLEPKIQYLYVPEKYQDNIGLYDSTLLQTDYYGLFRSRKYSGVDRIESANQVSYGASTRFFDSNYKERLNIAFGQIFYLDSKLNPSNKNPDSTSDKTSYSAWAVEMDFNFADYLFYHGGIQYDIDSQAVQLGNSTLEYRVASGYIQANYRYVAKDYIRNTVGDSITNIDDITRDGISQAGILAGYQLSRKWSASGQYYYDLTTDEALEWLANLTYTSDCWYVGFTYSNQLKSWNGNFVTDPYATPIYENNFSFNIGIIGFGTSIGAGSSMTGVDSAGNSLGYGRPFFLNN
>NC_012668.1|WP_000780524.1|145509_146805_+|peptidylprolyl-isomerase-SurA
MKLWKPTLISVLSALTLFNAHAEPKQLDSVAVIVNSGVILQSDVDSALKTIKANAKQNKQPLPQETVLREQVLEKLIIDTLQQQEADRIGVKIDDNRLNEAIKEIAKNNQQTQEQLIASVAQEGLTYPEFREQVRKEMAASDARNALVRRRINILPAEVDTLAELLAQETDATVQYKISHIQLRVDDGQDKSTAETLANKLVNDLRNGADFAQMAYAYSKGPKALQGGDWGWMRKEEMPTIFADQIKMQNKGSIIGPFRSGVGFHILKIDDVKGLETVAVTEVNARHILIKPTIILSDEGAQKQLNEFVQRIKNGEVTFAELAQQYSQDPGSAAQKGELGYQTPDLYVPEFKHQIETLPVGQISEPFKTVHGWHIVEVLDRREVDRTDSALKNKAYRILFNRKFNEEASAWLQELRASAFVEVLKDEKDEQ
>NC_012668.1|WP_000095773.1|146794_147787_+|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA
MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQRDNPVQAQQAGTLLVEHIPLAEPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPVHKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTALVTTHLPLAEVPQAITCERLEQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMDEIETITPTLQRLREQYGMQLVGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGTGQADAGSFWTALAYAIELVDKKAQ
>NC_012668.1|WP_001243262.1|147800_148616_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MRNDVHLGHKARKRFGQNFLNDPYIIDGIVSAINPKPGQNLVEIGPGLGAITEPVGREVDKFTVIELDRDLAERLRNHPELASKLTIHEGDAMRFDFKQLVKPNNKLRVFGNLPYNISTPLMFHLFEFHRDIQDMHFMLQKEVVNRLAAGPGTKAYGRLTVMAQYYCKVVPVLEVPPSAFVPPPKVDSAVVRLVPYEDLPHPATSLEWLDRVVREGFNQRRKTVRNCYKGLAEPETLETLGINPGMRPENLTLAQFVALANWLDATHKTHA
>NC_012668.1|WP_000383338.1|148687_149068_+|Co2+/Mg2+-efflux-protein-ApaG
MDVSLPCIKIQVQTRYIEEQSNPEYQRFVFAYLITIKNLSSQTVQLMSRRWLITDADGKQTVVEGDGVVGEQPRIKANDEYTYSSGTALDTPVGVMQGQYLMIDEQGESFTVEIEPFRLAVPHVLN
>NC_012668.1|WP_000035032.1|149078_149888_+|symmetrical-bis(5'-nucleosyl)-tetraphosphatase
MANYIVGDIQGCFDELQQLLKQAEFNSQLDTLWFAGDLVARGPKSLETLRFVYQLGDAARVVLGNHDLHLLSVALGHHSAKRRDQTQAVLDAPDAAPLLDWLRQQPLLAEHQEFVLCHAGISPQWDLATARQAAQEVESVLRSPEWSTLIEQMYSDQPDAWHPTLQGIDRLRYIVNAFTRMRFCFPDGRLDMQCKLPPKEVTDGSLLPWFQLPQRIALEKTVIFGHWAALEGYVSETVIGLDTGCVWGGTLTMLRWEDKHYFSQAALPA
>NC_012668.1|WP_000973535.1|150036_150534_-|type-3-dihydrofolate-reductase
MMISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIVISRDASLQIEGVDVVTSIEAALAKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHAKLDGDTQFPEWGSDWLERSREHYPADEKNAYGMDFVIFERQYPLPT
>NC_012668.1|WP_001892423.1|150546_151032_-|hypothetical-protein
MGVVMLSWDLFFGLLNDMFFAAIPAVGFALVFNVPVPALKYCALGGALGHGSRYLMMHFGVPIEWASFFAATLVGMVGVYWSRRFLAHPKVFTVAALIPMVPGVFAFKAMIALVEINHVGFSPELMEALLENFLKAMFIIAGLAVGLAVPGLLFYRRKPII

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_012668_1	1.1\|138937\|37\|NC_012668\|PILER-CR	138937-138973	37	NC_049942	Escherichia phage JLK-2012, complete sequence	23524-23560	4	0.892
NC_012668_1	1.1\|138937\|37\|NC_012668\|PILER-CR	138937-138973	37	NC_021742	Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence	35428-35464	4	0.892

1. spacer 1.1|138937|37|NC_012668|PILER-CR matches to NC_049942 (Escherichia phage JLK-2012, complete sequence) position: , mismatch: 4, identity: 0.892

taggtcgccagttcgattccggcagccggcaccactt	CRISPR spacer
caggtcgccagttcgattccggtagccggcaccatat	Protospacer
.*********************.***********. *

2. spacer 1.1|138937|37|NC_012668|PILER-CR matches to NC_021742 (Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.892

taggtcgccagttcgattccggcagccggcaccactt	CRISPR spacer
taggtcaccagttcgattccggtagccggcaccaatc	Protospacer
******.***************.*********** *.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

50762 : 58025

uncultured_Mediterranean_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001279365.1\|50762_51650_+	cysteine synthase CysM	A0A1X9I5K7	Streptococcus_phage	4.1e-56	41.1
WP_001894770.1\|51917_54506_+	DNA mismatch repair protein MutS	A0A1V0SC35	Catovirus	2.2e-33	23.0
WP_000116737.1\|54598_55606_-	RNA polymerase sigma factor RpoS	F4YCU2	Synechococcus_phage	6.0e-35	34.2
WP_000177568.1\|55679_56615_-	murein hydrolase activator NlpD	D7RWE0	Brochothrix_phage	7.8e-05	34.7
WP_000002982.1\|56614_57241_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	2.0e-36	52.1
WP_001883363.1\|57233_58025_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	8.4e-69	51.6

DBSCAN-SWA_2

1165272 : 1171889

Staphylococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000210573.1\|1165272_1166406_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.4e-64	40.4
WP_001890340.1\|1166414_1167668_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	5.0e-100	49.5
WP_000543544.1\|1167767_1168217_+	transcriptional regulator NrdR	NA	NA	NA	NA
WP_001131994.1\|1168242_1169346_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	1.3e-43	33.1
WP_000493874.1\|1169350_1170004_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.2e-31	38.2
WP_001122865.1\|1170044_1171154_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	6.7e-64	39.8
WP_000864130.1\|1171418_1171889_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	6.8e-34	48.7

DBSCAN-SWA_3

1226688 : 1292654

Vibrio_phage(91.3%)

integrase,tail,head,portal,capsid,terminase,tRNA

attL 1260229:1260252|attR 1293338:1293361

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000216841.1\|1226688_1228113_+\|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
WP_000731531.1\|1228408_1229374_+	OmpA family protein	NA	NA	NA	NA
WP_001017843.1\|1229462_1230161_-	Fe3+-citrate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000279435.1\|1230580_1232644_+	TonB-dependent siderophore receptor	NA	NA	NA	NA
WP_000064348.1\|1232947_1233763_+	siderophore-interacting protein	NA	NA	NA	NA
WP_001923521.1\|1234020_1241262_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	2.9e-30	22.9
WP_000739493.1\|1241391_1242525_-	hypothetical protein	NA	NA	NA	NA
WP_000759070.1\|1242685_1243321_+	membrane protein	NA	NA	NA	NA
WP_001881911.1\|1243328_1243766_+	flagellar assembly lipoprotein FlgP	NA	NA	NA	NA
WP_001881909.1\|1243875_1244307_-	molecular chaperone	NA	NA	NA	NA
WP_000907265.1\|1244404_1244728_-	flagellar biosynthesis anti-sigma factor FlgM	NA	NA	NA	NA
WP_001881906.1\|1244858_1245626_-	flagellar basal body P-ring formation protein FlgA	NA	NA	NA	NA
WP_000145786.1\|1245682_1246609_+	chemotaxis protein CheV	Q56AR1	Bacillus_thuringiensis_phage	1.4e-35	31.6
WP_000125387.1\|1246619_1247447_+	chemotaxis protein methyltransferase 1	NA	NA	NA	NA
WP_001007981.1\|1247666_1248062_+	flagellar basal body rod protein FlgB	NA	NA	NA	NA
WP_000051920.1\|1248066_1248483_+	flagellar basal body rod protein FlgC	NA	NA	NA	NA
WP_000929365.1\|1248500_1249208_+	flagellar hook assembly protein FlgD	NA	NA	NA	NA
WP_000122825.1\|1249236_1250541_+	flagellar hook protein FlgE	NA	NA	NA	NA
WP_000373284.1\|1250723_1251473_+	flagellar basal-body rod protein FlgF	NA	NA	NA	NA
WP_001182097.1\|1251492_1252281_+	flagellar basal-body rod protein FlgG	NA	NA	NA	NA
WP_000729679.1\|1252295_1253081_+	flagellar basal body L-ring protein FlgH	NA	NA	NA	NA
WP_001225051.1\|1253171_1254257_+	flagellar basal body P-ring protein FlgI	NA	NA	NA	NA
WP_000609516.1\|1254267_1255206_+	flagellar assembly peptidoglycan hydrolase FlgJ	S5M9Y4	Brevibacillus_phage	9.5e-11	31.9
WP_000135483.1\|1255385_1257260_+	flagellar hook-associated protein FlgK	NA	NA	NA	NA
WP_000934642.1\|1257272_1258466_+	flagellar hook-associated protein FlgL	NA	NA	NA	NA
WP_001938933.1\|1258563_1258725_+	hypothetical protein	NA	NA	NA	NA
WP_000154827.1\|1258873_1260013_+	flagellin	NA	NA	NA	NA
1260229:1260252	attL	NA	NA	NA	NA
WP_000116333.1\|1260461_1261499_-\|integrase	site-specific integrase	U3PIJ4	Vibrio_phage	1.5e-198	100.0
WP_000985033.1\|1261498_1261912_-	hypothetical protein	U3PDE6	Vibrio_phage	8.9e-70	100.0
WP_000132153.1\|1261911_1262817_-	NAD-dependent DNA ligase	U3PB51	Vibrio_phage	1.3e-161	100.0
WP_001881894.1\|1262842_1263490_-	phage repressor protein CI	A0A166YHA0	Vibrio_phage	1.1e-119	100.0
WP_000959026.1\|1263635_1263848_+	hypothetical protein	U3PFJ1	Vibrio_phage	6.4e-32	100.0
WP_000253093.1\|1263958_1264498_+	hypothetical protein	U3PIJ8	Vibrio_phage	5.5e-96	100.0
WP_001272765.1\|1264510_1264945_+	hypothetical protein	U3PDF0	Vibrio_phage	2.8e-74	100.0
WP_001031152.1\|1265026_1265560_+	hypothetical protein	U3PB56	Vibrio_phage	3.9e-86	100.0
WP_000997540.1\|1265556_1265967_+	hypothetical protein	U3PCE8	Vibrio_phage	1.8e-75	100.0
WP_001881891.1\|1265968_1266214_+	hypothetical protein	U3PFJ5	Vibrio_phage	2.4e-46	100.0
WP_001198814.1\|1266216_1266444_+	hypothetical protein	U3PIK2	Vibrio_phage	3.2e-37	100.0
WP_000099608.1\|1266440_1267058_+	DNA methyltransferase	U3PDF3	Vibrio_phage	1.2e-118	100.0
WP_000629095.1\|1267054_1267165_+	hypothetical protein	NA	NA	NA	NA
WP_000613058.1\|1267161_1267746_+	hypothetical protein	U3PB60	Vibrio_phage	3.2e-105	100.0
WP_001909657.1\|1267742_1270328_+	replication endonuclease	A0A166YHE2	Vibrio_phage	0.0e+00	99.9
WP_000756239.1\|1270337_1270874_+	DUF262 domain-containing protein	U3PFK3	Vibrio_phage	4.1e-99	100.0
WP_001140408.1\|1270947_1271286_-	helix-turn-helix transcriptional regulator	U3PIK7	Vibrio_phage	2.8e-53	100.0
WP_001292395.1\|1271523_1271769_+	hypothetical protein	U3PDF9	Vibrio_phage	1.5e-37	100.0
WP_001263191.1\|1271769_1272021_-	ogr/Delta-like zinc finger family protein	U3PB63	Vibrio_phage	1.9e-43	100.0
WP_000729650.1\|1272091_1272307_-	hypothetical protein	U3PCF7	Vibrio_phage	3.1e-34	100.0
WP_001999948.1\|1272290_1273337_-\|portal	phage portal protein	U3PFK6	Vibrio_phage	5.7e-206	100.0
WP_000331803.1\|1273333_1275151_-\|terminase	terminase ATPase subunit family protein	U3PIL1	Vibrio_phage	0.0e+00	100.0
WP_001127095.1\|1275324_1276224_+\|capsid	GPO family capsid scaffolding protein	A0A160DHM4	Vibrio_phage	4.0e-123	100.0
WP_000078361.1\|1276260_1277271_+\|capsid	phage major capsid protein, P2 family	U3PB67	Vibrio_phage	7.0e-193	100.0
WP_000059165.1\|1277286_1278003_+\|terminase	terminase endonuclease subunit	U3PCG2	Vibrio_phage	1.3e-132	100.0
WP_000493401.1\|1278109_1278571_+\|head	head completion/stabilization protein	U3PFL1	Vibrio_phage	1.5e-78	100.0
WP_000122189.1\|1278567_1279056_+	hypothetical protein	U3PIL4	Vibrio_phage	1.6e-89	100.0
WP_000461677.1\|1279042_1279702_+	phage virion morphogenesis protein	U3PDG7	Vibrio_phage	9.1e-117	100.0
WP_000312540.1\|1279703_1280813_+	DUF2586 family protein	U3PB71	Vibrio_phage	1.5e-209	100.0
WP_000063627.1\|1280812_1281271_+	DUF2597 family protein	U3PCG7	Vibrio_phage	1.3e-82	100.0
WP_000382491.1\|1281285_1281495_+	TraR/DksA family transcriptional regulator	U3PFL5	Vibrio_phage	2.0e-33	100.0
WP_001077689.1\|1281491_1281719_+	hypothetical protein	U3PIL8	Vibrio_phage	2.1e-36	100.0
WP_000705022.1\|1281705_1282293_+	lysozyme	U3PDH1	Vibrio_phage	2.5e-110	100.0
WP_000990572.1\|1282267_1282609_+	hypothetical protein	U3PB75	Vibrio_phage	1.1e-52	100.0
WP_000165786.1\|1282816_1283098_+	hypothetical protein	A9ZT39	Vibrio_virus	5.1e-45	100.0
WP_000343647.1\|1283294_1285112_+\|tail	phage tail tape measure protein	U3PFL8	Vibrio_phage	0.0e+00	100.0
WP_001113003.1\|1285101_1285434_+	DUF2590 family protein	U3PIM1	Vibrio_phage	1.7e-55	100.0
WP_000044509.1\|1285430_1286630_+	hypothetical protein	U3PDH5	Vibrio_phage	1.0e-222	100.0
WP_000005870.1\|1286626_1287286_+	hypothetical protein	U3PB79	Vibrio_phage	8.2e-126	100.0
WP_000083759.1\|1287282_1289145_+\|tail	phage tail protein	Q8HA58	Vibrio_phage	0.0e+00	100.0
WP_000369865.1\|1289144_1289669_+	hypothetical protein	U3PFM2	Vibrio_phage	1.1e-96	100.0
WP_000267787.1\|1289671_1290565_+	hypothetical protein	U3PIM3	Vibrio_phage	2.8e-161	100.0
WP_000457681.1\|1290552_1291026_+	hypothetical protein	U3PDI0	Vibrio_phage	6.6e-77	100.0
WP_000779002.1\|1291022_1292654_+	hypothetical protein	U3PB83	Vibrio_phage	0.0e+00	100.0
1293338:1293361	attR	NA	NA	NA	NA

DBSCAN-SWA_4

2855417 : 2862610

Anguillid_herpesvirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001162850.1\|2855417_2855846_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	1.0e-20	38.4
WP_000107237.1\|2856049_2857339_-	aminopeptidase PepB	Q6GYZ8	Mycoplasma_phage	1.7e-34	34.3
WP_000872176.1\|2857558_2857753_-	Fe-S cluster assembly protein IscX	NA	NA	NA	NA
WP_001124187.1\|2857801_2858140_-	ISC system 2Fe-2S type ferredoxin	NA	NA	NA	NA
WP_001196560.1\|2858153_2860004_-	Fe-S protein assembly chaperone HscA	A0A0N9QXN8	Chrysochromulina_ericina_virus	5.3e-106	41.1
WP_001105747.1\|2860027_2860543_-	co-chaperone HscB	NA	NA	NA	NA
WP_000301571.1\|2860591_2860915_-	iron-sulfur cluster assembly protein IscA	A0A2H4N7N5	Lake_Baikal_phage	3.0e-25	50.5
WP_000331703.1\|2860975_2861359_-	Fe-S cluster assembly scaffold IscU	A0A218MKD1	uncultured_virus	5.4e-53	78.2
WP_000775253.1\|2861395_2862610_-	IscS subfamily cysteine desulfurase	A0A0H3TPH2	Faustovirus	1.1e-32	30.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_012667

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_012667_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012667_1

945322-945424

Orphan

Consensus_repeat	Method
TGGGATGATTTTCATACCTATAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012667_1

>merge|NC_012667|1|945322-945424|CRISPRCasFinder
TGGGATGATTTTCATACCTATAAAGTATGTTTATATGGATGATTTTCAGCCCTATAAGATTCTCTAAGCTTTTATTTATATGGGTGATTTTCATACCTATAAA

>NC_012667|1|1|945322-945424|CRISPRCasFinder
TGGGATGATTTTCATACCTATAAA	GTATGTTTATATGGATGATTTTCAGCCCTATAAGATTCTCTAAGCTTTTATTTAT
ATGGGTGATTTTCATACCTATAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012667.1\|WP_000403010.1\|938861_939146_-\|hypothetical-protein	unknown	unknown	unknown
NC_012667.1\|WP_000033350.1\|947462_948503_+\|hypothetical-protein	unknown	unknown	unknown
NC_012667.1\|WP_000628296.1\|952069_952291_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274373
NC_012667.1\|WP_001125479.1\|940253_941912_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238206
NC_012667.1\|WP_000254716.1\|937051_937924_-\|DUF3800-domain-containing-protein	unknown	unknown	unknown
NC_012667.1\|WP_000477436.1\|939441_939936_+\|hypothetical-protein	unknown	unknown	unknown
NC_012667.1\|WP_001050346.1\|942410_942803_-\|hypothetical-protein	unknown	unknown	unknown
NC_012667.1\|WP_000701627.1\|947302_947485_+\|hypothetical-protein	unknown	unknown	unknown
NC_012667.1\|WP_000503169.1\|938380_938818_-\|IS200/IS605-like-element-IS1004-family-transposase	unknown	unknown	gnl\|CDD\|376616
NC_012667.1\|WP_001147213.1\|951580_952057_+\|hypothetical-protein	unknown	unknown	unknown
NC_012667.1\|WP_000245610.1\|936302_936983_-\|glutathione-S-transferase	unknown	unknown	gnl\|CDD\|273527
NC_012667.1\|WP_001902294.1\|952290_953058_+\|hypothetical-protein	unknown	unknown	unknown
NC_012667.1\|WP_000138495.1\|950110_950833_+\|hypothetical-protein	unknown	unknown	unknown
NC_012667.1\|WP_000130749.1\|943197_943485_-\|hypothetical-protein	unknown	unknown	unknown
NC_012667.1\|WP_000917367.1\|942802_943177_-\|hypothetical-protein	unknown	unknown	unknown
NC_012667.1\|WP_071908318.1\|938098_938317_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|236715
NC_012667.1\|WP_000873011.1\|947059_947296_+\|hypothetical-protein	unknown	unknown	unknown
NC_012667.1\|WP_000011023.1\|948588_949440_+\|hypothetical-protein	unknown	unknown	unknown
NC_012667.1\|WP_001164594.1\|945975_946689_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|370445
NC_012667.1\|WP_000283749.1\|950836_951136_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_012667.1\|WP_000628296.1\|952069_952291_+\|hypothetical-protein	gnl\|CDD\|274373	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. This group of similar sigma-70 factors includes clades found in Bacilli (including the sporulation factors SigF:TIGR02885 and SigG:TIGR02850 as well as SigB:TIGR02941), and the high GC gram positive bacteria (Actinobacteria) where a variable number of them are found depending on the lineage.	0.00832648
NC_012667.1\|WP_000245610.1\|936302_936983_-\|glutathione-S-transferase	gnl\|CDD\|273527	TIGR01262, Maleylacetoacetate_isomerase, maleylacetoacetate isomerase. Maleylacetoacetate isomerase is an enzyme of tyrosine and phenylalanine catabolism. It requires glutathione and belongs by homology to the zeta family of glutathione S-transferases. The enzyme (EC 5.2.1.2) is described as active also on maleylpyruvate, and the example from a Ralstonia sp. catabolic plasmid is described as a maleylpyruvate isomerase involved in gentisate catabolism. [Energy metabolism, Amino acids and amines].	2.23861e-31
NC_012667.1\|WP_001125479.1\|940253_941912_+\|hypothetical-protein	gnl\|CDD\|238206	cd00338, Ser_Recombinase, Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.	8.19939e-10
NC_012667.1\|WP_071908318.1\|938098_938317_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|236715	PRK10562, PRK10562, putative acetyltransferase; Provisional.	5.69546e-10
NC_012667.1\|WP_000503169.1\|938380_938818_-\|IS200/IS605-like-element-IS1004-family-transposase	gnl\|CDD\|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	2.14302e-46
NC_012667.1\|WP_001164594.1\|945975_946689_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|370445	pfam09339, HTH_IclR, IclR helix-turn-helix domain.	1.02688e-05

>NC_012667.1|WP_000130749.1|943197_943485_-|hypothetical-protein
MTDLKSKKLIQIQNEIFSLCKILMKQHYRSNKKTAAIVAMLGLNLTGSQVVEMMQEIEGEKVSLSSVHKARERYRPIVKMLQEETNRLYSLHGFI
>NC_012667.1|WP_000917367.1|942802_943177_-|hypothetical-protein
MLKPLPIQSSTQGRVTKRKEINVLCAEVTQEKIAAVDKIKGKIPKMIKQLQDIIDHPDTTDSNRMKAIAQLTAMLERWESDLTKIKNDEEYLDTTTEQQQQQPTTTRKNSSTVDIMALLEKDGK
>NC_012667.1|WP_001050346.1|942410_942803_-|hypothetical-protein
MNLLDEFKPVLKIKRQCIGNCAMYRVLLAVGYTKEELQSGYGIHQPLISLIPIGAESEINSFLDGKLEIFNALLQQVGFDAMRYTLQQWFAGLEKDGRYMDYSLMDSSWENVKKSVIPLVLNPEVKFEYV
>NC_012667.1|WP_001125479.1|940253_941912_+|hypothetical-protein
MPKLYIFRRVSSKRQTNKTGLKIQVRPETVERLLSEHGLSEVVDLGAEVASASKGKHIEEGSILKRFLMKCERGEIEQGSILAVYSLDRLSRLEKLGLAKSLIYLPITNNGVSIFGEIDNFLYKPHDVLSEILSSLVFERAAEESRAKKNRNIDSLAANLAQYQRDGQYTTKLGKSPSWINHKTGKLNEEAVLWREVINCYTSGQYKNLSALHTAMQLAIPYNTLSKVINNAHKTLIGTKVIKGVELAEFYEPLLTQEEYNRLLIYVRQMGTGRGKAIATTKTENIWLLKGLGECPECGSLCGSFKNGASVKDKVRYNYRCNAAINKHCDSPTYNLNPIEAIVTLLSADYLHEVSQRETNTELNAKIEAMQVEVERLETQLDQATQALNTFFSPELAQAIPKYREQLETAQNELQTLLALASNHTPINESLLSAEIILDKANPERMKLVKLLQGCINRVIVTRKSVKKGDIRFNPKIYTGCDYSLLCVRVEFIDGNIRVFDSVLRDNLRLNLSVSNGTRSIGLENFHRFSRRLREYDLIKYCVINNRKLKIT
>NC_012667.1|WP_000477436.1|939441_939936_+|hypothetical-protein
MFKVLIHERSKDVKILPDGGFDLTVLLFGVFVPLWRGQYKRALSYLAIVICTLFVAWVFIPFFSNKHYIKDLLEKDGYLLAEDYTGIKPVIPNTSPLMIMLKDFVSWFMFIHVLLGVLGLFILGDLLLAVTIIALFGLGLALRYHRALAKHQAITKYNEVSNAA
>NC_012667.1|WP_000403010.1|938861_939146_-|hypothetical-protein
MEIKEFSACNLESLRKLYLDSRRDSFPWLKADSFRIEDFDRDSQGERIWLSEVLGNVAGFISIWEPDNFIVIPKPPLLAVVIVPRGFCPKMRPC
>NC_012667.1|WP_000503169.1|938380_938818_-|IS200/IS605-like-element-IS1004-family-transposase
MGDYRSSSHVYWRCKYHIVWTPKFRFKILKGNVAKELNRSIYILCNMKDCEVLELNVQPGHVHLVAIIPPKVSISTLMGVLKGRSAIRLFNKFPHIRKKLWGNHFWARGYFVDTVGVNEEIIRRYVRHQDKKELEQEQQLELLRD
>NC_012667.1|WP_071908318.1|938098_938317_-|GNAT-family-N-acetyltransferase
MHHLYVATEYQGQGVGSMLLNGAKMKYGNLSLKCMVQNQKALNFYLSQGFEIVSQVDDELGGYYYMSFVAQT
>NC_012667.1|WP_000254716.1|937051_937924_-|DUF3800-domain-containing-protein
MVSRSAPLPRLDINGRAFVYLEAGKLLYIVYLDEFGHIGPYLSSTDKSHKTHPVFGLGGVVLPYTEVRKFSTYFYQLKNRLLDYELKNSGIHPAKWEKKGASLYTVTNVTKYRQLRQATFRLLNKVKASGGFIIYVGIEKERRVDGHDSKRLYHSVLREVIKCIDQECEQRDAKFMLILDQQEENVLRGEIVETASVAMFGDDARYRLIEPPVQVESHLYQTVQCADWLCGLFGRLAHYECEPTVKADYKAIHDYFDNCIHQVSTRSGIKKLKSRPTAHNLQKLVDKFSS
>NC_012667.1|WP_000245610.1|936302_936983_-|glutathione-S-transferase
MVMVVLFEFSGNALPAPWAGVMFFGVKMDLSLYSAKGSNSSERVEWMLNFKGIPYERIEVSSDDLATTYRVMNPFGYVPSLLVDGLVFTESMAIAEYLEERFPTSPLLGQSLEEKTKIRSVCEYVNSSIHSPQNRTVLNFFRPDLDETSKRKVRGEWIMLCLDKLSQTICNESGFIIGRTFSLADIFVASIYKKALQHGYVESEFYNNHLIYIRKNERVAVSEPQT
>NC_012667.1|WP_001164594.1|945975_946689_+|helix-turn-helix-domain-containing-protein
MQHNTPYLPHQSLQLQSRLIKLYQNVGLFVPKLTFCFSVDNAETDTHYYNVWFSSNVDGELIIGECNTYEKATLIAQQWLDNTTDEDLLHLVQSVLSRGYTDGFSECVEGVRQADKLTSNELLVLECLRPQLDFEEGSESGQYPWSNTDISDKTGIHRSNLHRVLKSLVNKGLIVEETVKRDVWASLKKCGHVQKDVLVYYPVATREEDLEVMENWHEWRAIRQKEAMQKWRAMLSS
>NC_012667.1|WP_000873011.1|947059_947296_+|hypothetical-protein
MKYEIPPSLNLKELPLTTQYQLNRMLNGEIRPSAIRRNKANYKLKGDKDKVFENGLAVRLFNLIREYNNVESVESEEV
>NC_012667.1|WP_000701627.1|947302_947485_+|hypothetical-protein
MKIQLKHPYDKLAGELADLTGLSPTQLTIQLMQELQTKISETSAQEEAKENKNNVKVLPN
>NC_012667.1|WP_000033350.1|947462_948503_+|hypothetical-protein
MSKFYQINTTLLESNEAVNKQTGDVVPLSPETKLVYAYMLNQYRMHRKYGNRRYTESWDKIFTVCCDVAAQKQKKLAKELTTLGLIEVIGNKNAYKVVHSVESIMEAWELTNSKLNTFKDPTQTTKRKESKKQRLNKWEEDKRSKGEWKDFKEPHLEEMQDCNGAESYFTEQPPVEAYEQDYRPIAGDAVNFGVLADIDISDTPTSDQWDCPPEDEPESLTPAKDEPQEVVEVVTPQVVEHVTPVVCGDKSKLLKCFRPNTDISEIDISGKGIGFFAKPLHNKECDKGTARQYLKVIKAYYWDQYNPDDATIDKILGWLVCEVCGNYTDDRGYCSNPNCSTNALPF
>NC_012667.1|WP_000011023.1|948588_949440_+|hypothetical-protein
MSFTKSEILEALQSNLEITNINCNTATLKFKYDNTPFEILLSKMCIKSKNKGFAGSYRTFKSLPELVQLVKSCERFILGDGLVDTIPDLLYKAKVRDAQFIEDCYYKESAYYKLKRELSNNSDYAKKSFKEIKDSCDDFKNWWDRIALPDNWEDFKTWCDTNNCSTQIALELILRRLRFLPSDSGVKAVRFCNIFYWYNGTYRNAKGKTHYQSKNLLHVIRLQDSFNPLEGANIDDYSLLPTDKATLTKEIAMFLSNTEFYKLDMQAYTKGYKDSYVLDTKAL
>NC_012667.1|WP_000138495.1|950110_950833_+|hypothetical-protein
MTENQTLKGSVDPLPTITLYASGVPVEIAGRIISKSKNSVNYMLYGYRLVDLITHPVINANKHSKQRLYKNLKEIDPIIRNSRQLYTLCPDFLQLWVNRLQQPKLSTDAYKPAENSCYGNILNPEMSRRVKRKRSEEIWPDVLNSFVGVRKITINGNTYYLDKYEHRQYLKMTAGKPAFTRWVNETLFEVWLIAAQPKYRKVKVNHYNEPVKLATYEDFTNSMYEHKLNTNVPQQTEEDY
>NC_012667.1|WP_000283749.1|950836_951136_+|hypothetical-protein
MYQAEFKTKEGARYTVVFTQYVCAMPNPDTLHVTSNRFDFKITRIKNDRSITQDVNFNLKIDGKVIPATQYTVSGQNSKRTSKQTDVILSNYYNWVDLI
>NC_012667.1|WP_001147213.1|951580_952057_+|hypothetical-protein
MPYYSKNAERAALIGCTLPQLKKLNVQFLNIKYRCGKLKGYENTKFKLGTFDDFIEWIASQGGYKTSPHGHTYHVSRIRDQGDYAYNNIRWCSHQENLKETAHFWLVTDIKTSRQELFQGNLTTKLKELFDVSGYGAYKAAESGRLYKGRFKIDKLSI
>NC_012667.1|WP_000628296.1|952069_952291_+|hypothetical-protein
MITIELLNARLALLSPTERKALRLMLTTNLTNAEINKELGVSHNYVYWLKNESPHAETVQMFLNLNNKFKETK
>NC_012667.1|WP_001902294.1|952290_953058_+|hypothetical-protein
MITINLKLGNNESITRTYSQISIEESRIILDTPMESVNQTVLSFANGVLSSITVTEPKQGISTMPQATTRSAVYATISNKGLVLNFTTYATLSVMLSGISANAEIVKGLKQKPAQQQVVKSAALGKETPEQTQQRLQRALAAKQSKQANTGVGGVDKQKIYNELNKARNPIKSGKELAKIANTKQTELVKCGAIMKGNSEWEELVKYLQGGDFTFDAFDAFSDVLKERDYSTCLTKIRALASRLNIVNGVIHLIK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

852232 : 858550

Vibrio_phage(77.78%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000593519.1\|852232_852607_-	cholera enterotoxin binding subunit CtxB	A0A142I6Y1	Vibrio_phage	5.9e-65	100.0
WP_001881225.1\|852603_853380_-	cholera enterotoxin catalytic subunit CtxA	A0A142I6Y0	Vibrio_phage	1.3e-151	100.0
WP_000021616.1\|853478_854678_-	zonula occludens toxin ZOT	A0A142I6Z1	Vibrio_phage	5.3e-240	100.0
WP_000979342.1\|854674_854968_-	accessory cholera enterotoxin	A0A0F6YNQ7	Vibrio_phage	3.7e-46	100.0
WP_001881237.1\|854964_856248_-	hypothetical protein	A0A142I701	Vibrio_phage	9.1e-222	100.0
WP_000493022.1\|856258_856507_-	colonization factor	A0A0N7F140	Vibrio_phage	8.8e-33	100.0
WP_001890610.1\|856642_857026_-	hypothetical protein	F1CC65	Vibrio_virus	4.8e-70	100.0
WP_000743997.1\|857003_858083_-	hypothetical protein	U5TQR3	Satellite_phage	2.2e-213	100.0
WP_000492997.1\|858214_858550_+	helix-turn-helix transcriptional regulator	A0A0N9HJE7	Vibrio_phage	4.7e-53	100.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_012668

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_012667

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection