CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_012669	Beutenbergia cavernae DSM 12333, complete sequence	12 crisprs	WYL,csa3,cas3,DEDDh,DinG	2	1	0	0

Cas Category Instructions

Results visualization

1. NC_012669

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CRISPR-Cas detection and classification

Crispr_ID: NC_012669_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012669_1

59201-59350

Orphan

Consensus_repeat	Method
CGAGCTCGTACCCAGGCGGCGACGTCGTACTCCCGGGAGTACGAGCTCGCCGGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012669_1

>merge|NC_012669|1|59201-59350|CRISPRCasFinder
CGAGCTCGTACCCAGGCGGCGACGTCGTACTCCCGGGAGTACGAGCTCGCCGGGAAGGTACGAACTCGCGCGGGACGGGGGTGGCCGTGCTCCGCCGAGCTCGTACCCAGGCGGCGACGTCGTACTCCGGGGAGTACGAGCTCGCCGGGA

>NC_012669|1|1|59201-59350|CRISPRCasFinder
CGAGCTCGTACCCAGGCGGCGACGTCGTACTCCCGGGAGTACGAGCTCGCCGGGA	AGGTACGAACTCGCGCGGGACGGGGGTGGCCGTGCTCCGC
CGAGCTCGTACCCAGGCGGCGACGTCGTACTCCGGGGAGTACGAGCTCGCCGGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012669.1\|WP_012725103.1\|59500_61432_+\|glycoside-hydrolase-family-127-protein	unknown	unknown	gnl\|CDD\|226063
NC_012669.1\|WP_083769896.1\|53587_54091_+\|DUF4232-domain-containing-protein	unknown	unknown	gnl\|CDD\|379419
NC_012669.1\|WP_012725111.1\|69196_70729_+\|alpha-N-arabinofuranosidase	unknown	unknown	gnl\|CDD\|226064
NC_012669.1\|WP_012725106.1\|64224_65181_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012669.1\|WP_144016659.1\|56586_57096_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NC_012669.1\|WP_012725107.1\|65180_65867_+\|YesL-family-protein	unknown	unknown	gnl\|CDD\|227865
NC_012669.1\|WP_012725095.1\|51325_52558_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340897
NC_012669.1\|WP_012725093.1\|49745_50270_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_012669.1\|WP_012725112.1\|70798_71659_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|236717
NC_012669.1\|WP_012725104.1\|61485_63141_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270299
NC_012669.1\|WP_012725102.1\|58131_59139_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_012669.1\|WP_012725110.1\|68460_68988_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379082
NC_012669.1\|WP_012725109.1\|67870_68305_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_012669.1\|WP_043346342.1\|57151_58135_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224525
NC_012669.1\|WP_012725094.1\|50311_51277_+\|LD-carboxypeptidase	unknown	unknown	gnl\|CDD\|132882
NC_012669.1\|WP_012725099.1\|54915_56190_-\|glycoside-hydrolase-family-27-protein	unknown	unknown	gnl\|CDD\|269893
NC_012669.1\|WP_012725105.1\|63247_64210_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_012669.1\|WP_012725108.1\|65895_67686_+\|glycoside-hydrolase-family-127-protein	unknown	unknown	gnl\|CDD\|369609
NC_012669.1\|WP_012725098.1\|54094_54730_-\|GyrI-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|227169
NC_012669.1\|WP_012725096.1\|52567_53443_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_012669.1\|WP_012725103.1\|59500_61432_+\|glycoside-hydrolase-family-127-protein	gnl\|CDD\|226063	COG3533, COG3533, Uncharacterized protein conserved in bacteria [Function unknown].	1.8103e-120
NC_012669.1\|WP_083769896.1\|53587_54091_+\|DUF4232-domain-containing-protein	gnl\|CDD\|379419	pfam14016, DUF4232, Protein of unknown function (DUF4232). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.	4.81816e-15
NC_012669.1\|WP_012725111.1\|69196_70729_+\|alpha-N-arabinofuranosidase	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	7.0015e-171
NC_012669.1\|WP_012725106.1\|64224_65181_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.12487e-54
NC_012669.1\|WP_144016659.1\|56586_57096_-\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	8.66704e-10
NC_012669.1\|WP_012725107.1\|65180_65867_+\|YesL-family-protein	gnl\|CDD\|227865	COG5578, COG5578, Predicted integral membrane protein [Function unknown].	9.37209e-14
NC_012669.1\|WP_012725095.1\|51325_52558_+\|MFS-transporter	gnl\|CDD\|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.24679e-74
NC_012669.1\|WP_012725093.1\|49745_50270_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.0178e-14
NC_012669.1\|WP_012725109.1\|67870_68305_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.64157e-09
NC_012669.1\|WP_012725102.1\|58131_59139_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.98314e-80
NC_012669.1\|WP_012725110.1\|68460_68988_-\|AAA-family-ATPase	gnl\|CDD\|379082	pfam13238, AAA_18, AAA domain.	1.4822e-06
NC_012669.1\|WP_012725112.1\|70798_71659_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|236717	PRK10572, PRK10572, arabinose operon transcriptional regulator AraC.	3.52093e-38
NC_012669.1\|WP_043346342.1\|57151_58135_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.31808e-67
NC_012669.1\|WP_012725094.1\|50311_51277_+\|LD-carboxypeptidase	gnl\|CDD\|132882	cd07025, Peptidase_S66, LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein. LD-carboxypeptidase (Muramoyltetrapeptide carboxypeptidase; EC 3.4.17.13; Merops family S66; initially described as Carboxypeptidase II) family also includes the microcin c7 self-immunity protein (MccF) as well as uncharacterized proteins including hypothetical proteins. LD-carboxypeptidase hydrolyzes the amide bond that links the dibasic amino acids to C-terminal D-amino acids. The physiological substrates of LD-carboxypeptidase are tetrapeptide fragments (such as UDP-MurNAc-tetrapeptides) that are produced when bacterial cell walls are degraded; they contain an L-configured residue (L-lysine or meso-diaminopimelic acid residue) as the penultimate residue and D-alanine as the ultimate residue. A possible role of LD-carboxypeptidase is in peptidoglycan recycling whereby the resulting tripeptide (precursor for murein synthesis) can be reconverted into peptidoglycan by attachment of preformed D-Ala-D-Ala dipeptides. Some enzymes possessing LD-carboxypeptidase activity also act as LD-transpeptidase by replacing the terminal D-Ala with another D-amino acid. MccF contributes to self-immunity towards microcin C7 (MccC7), a ribosomally encoded peptide antibiotic that contains a phosphoramidate linkage to adenosine monophosphate at its C-terminus. Its possible biological role is to defend producer cells against exogenous microcin from re-entering after having been exported. It is suggested that MccF is involved in microcin degradation or sequestration in the periplasm.	1.08389e-71
NC_012669.1\|WP_012725099.1\|54915_56190_-\|glycoside-hydrolase-family-27-protein	gnl\|CDD\|269893	cd14792, GH27, glycosyl hydrolase family 27 (GH27). GH27 enzymes occur in eukaryotes, prokaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-N-acetylgalactosaminidase, and 3-alpha-isomalto-dextranase. All GH27 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH27 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.	4.65094e-83
NC_012669.1\|WP_012725105.1\|63247_64210_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	3.05473e-108
NC_012669.1\|WP_012725108.1\|65895_67686_+\|glycoside-hydrolase-family-127-protein	gnl\|CDD\|369609	pfam07944, Glyco_hydro_127, Beta-L-arabinofuranosidase, GH127. One member of this family, from Bidobacterium longicum, UniProtKB:E8MGH8, has been characterized as an unusual beta-L-arabinofuranosidase enzyme, EC:3.2.1.185. It rleases l-arabinose from the l-arabinofuranose (Araf)-beta1,2-Araf disaccharide and also transglycosylates 1-alkanols with retention of the anomeric configuration. Terminal beta-l-arabinofuranosyl residues have been found in arabinogalactan proteins from a mumber of different plantt species. beta-l-Arabinofuranosyl linkages with 1-4 arabinofuranosides are also found in the sugar chains of extensin and solanaceous lectins, hydroxyproline (Hyp)2-rich glycoproteins that are widely observed in plant cell wall fractions. The critical residue for catalytic activity is Glu-338, in a ET/SCAS sequence context.	3.12446e-65
NC_012669.1\|WP_012725104.1\|61485_63141_+\|extracellular-solute-binding-protein	gnl\|CDD\|270299	cd13581, PBP2_AlgQ_like_2, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	1.81979e-147
NC_012669.1\|WP_012725098.1\|54094_54730_-\|GyrI-like-domain-containing-protein	gnl\|CDD\|227169	COG4832, COG4832, Uncharacterized conserved protein [Function unknown].	8.31005e-65

>NC_012669.1|WP_012725102.1|58131_59139_+|LacI-family-DNA-binding-transcriptional-regulator
MKAPTLADVAAVAGVSAKTVSNVLLGRPGVSARTRESVREAIAQVGYAVNPAGRGLASGRTGRVAVVVPMLYQPYFAEMAERLILALEAHGLATTLRIAPDGRSELDAVLGVSTRDVDAVVICPHLLSAELIGDAVLPRPVVQVGGGPVDRIDGVIMGERAGAEAVARHLLDGGRRRIALVWNAPRGEMPSGSRYEGYRSVLAEHGIDVDPALIARGSDWDRRVSGYEAMVGLLQSGARFDAAMCVNDAVAVGALRALRGHGRRVPEDVAVTGFDDTDEGEFTTPSLTSVSPHQEDMVAAAVAMLVERLGGYDGAARHVQTSAHLVVRDSSRPPV
>NC_012669.1|WP_043346342.1|57151_58135_+|substrate-binding-domain-containing-protein
MPVTMRDVAALAGVSVKTVSRVVNLEPHTRPEVVRRVRAAIAELDWVPNGSARTLRTGRTGLVAVAVTELRRPHLAMLGEALVDEIGRRGLQAAVEPTHGDPARLRDLLDARGRIFDGLVLIGDPGEDLLTGLRAQHPVVLVHGGGRGTVDAVDADLVEAASLVARHLVVMGRSRPVLLGLDRGAGGVEAMRAALASAGVTEPAPAIGGVRTRADGADVVDRARRERPDLDTLVCGSDEVALGALAALARDGVAVPDDVAVIGFDDLDDGQFTTPSLTTVDPGPGRLARAAIDLLADRLSGTAPAEPRRVISPVELIRRESTLGGMS
>NC_012669.1|WP_144016659.1|56586_57096_-|histidine-phosphatase-family-protein
MAARRVHLLRHAMPAARPDADPRAWPLSDEGRAAAARLAGTLPAGLLLSSTEAKAVETITLAAGPPTTDARFGEVSRPGEPFDDAVVARRRAWVESRLDVRHAGWETPDEAAARFDAGVRAYPGEDMVIATHGMVMVAWLARVGVVSAGAAAGELWIGLAFPDLVTVCV
>NC_012669.1|WP_012725099.1|54915_56190_-|glycoside-hydrolase-family-27-protein
MGWNSWDCYGTTVTEAEVVANAEFMATHLRAHGWDTVVVDIAWYDPTAKAHGYNDDAPLELDAHGRQLPAPNRFPSAADGAGFGPLAAKVHELGLRFGLHVMRGIPRLAVDRDLPIAGTGWTARDAADTSSICPWNPDNYGLDHTHPAAQAYYDAQVAQFAAWGVDFVKADDMLWPYHHAEIEAYARAIERSGRPMELSLSPGRDISLAHLDHLRASSAMWRVSDDLWDRWDDVEAQFARMARWAPHQSPEGWADADMLPLGRIGIRAERGDDRHSRLTPAEQVTLLSLWVISRSPLMMGGDLPTSSPETIALLTNDAVLDVLRTSRASREVLREGDLVLWTAEGADDGGTRLVPSGAPVRYAAVFHLGDEPTRVRLALGDVGGLPTDAVVDVWSGEQVPTVAGALELDLPAHGAHLLRLSPRS
>NC_012669.1|WP_012725098.1|54094_54730_-|GyrI-like-domain-containing-protein
MPGKNGDVPFDVKRELPALYAPKNRAWDLLDVPPQQFLAVDGEGDPNTSEAYARAVEALYAVAYTLRFASKRDGFEFVVGPLEGLWWSPDPAVFTARAKEKWHWRMLITLPERLTGAQVTQAAAAAQAKKGLPAISDVRLERMHEGLCAQVLHLGSYDDETPVLAELHERYLPQLGLVPTGHHHEIYLGDPRRTAPEKLRTVIRQPVAPAP
>NC_012669.1|WP_083769896.1|53587_54091_+|DUF4232-domain-containing-protein
MRVRRVAVVVPPEGAPPACDPGVLAVRLHGADAFTGHRLLGLAVRNAGDTACSLSGYPDLAFRAASGELVDASVLDGDPFGARDLGARPLVLDPGAEAFAVAGWGAMSTSLDPDVTVAVLLTPPGGANPVELPVTSIPGYAPGSSLDVLDGGEVTVTAWAARFEDLL
>NC_012669.1|WP_012725096.1|52567_53443_-|hypothetical-protein
MVPRRAAALACALAASLAAAACTPPAPFPHEALDGLSVEVYQGRIDWGERVIELRITNDGEVPLVVTGANLEAPITAQNEPKTADRTVALRPGITRAMYVRLGVPLCGEIGDGGAHAVLDVETEDGLAARVEVPAADPDGYLDRAHSEDCAEQAFAAGATATFGDDVRIEERDGHLVGGLELTVVPVPGGPEVSVAEVGGTQLLAPLGGPVWSDPALLDLPDDGARVTLWFTAVRCDQHAYADDKRGKFVPIRSVVDGVAEDLFYVHLPQATRRSLGEYFALACGWDVDLG
>NC_012669.1|WP_012725095.1|51325_52558_+|MFS-transporter
MTTPRFSGARSGAGLLLLAVLLCALNLRAAITALPPVVGDVSAELGLTAGQVGLLTGVPVLCFAVATPAASGALGRWGVSRCGTVALVAIAVGSLVRSVDGFAVALAGTVLIGLGITIGNVTLPFLIGRDFPSAVAMVTGLYTAALNVGTTLTTSLTAPLAGLTGWRFAIASWSLLAVVALAVWWRAFARRPAPEVPPPPAAGTPSSPPPQQGERSVLRLGITWLLAATFATQAFSFYGVTAWLPTLLRDTVGIPADSAGGAAAVFQVFAIVGGVGVPLALARRASIRAVALTMSAFWLTLPIGLLLRPESWAWWASIAGISQGGMFAVIFTLVAWRAPSQSASRRTSATVQTIGYSVAALAPPLLGVVHTGTDGWTAPLVVVLCALLAMTGCVAVASAAPSARGREKPA
>NC_012669.1|WP_012725094.1|50311_51277_+|LD-carboxypeptidase
MWVAGRTVRRVSLPTPIATARPDASLLPRRLVPGDAVALVSPASTPSAEWIDWSVGTLESWGLEVRVGAHALDAQGILAGDDAARLADLNAALRDPAVRAVLTTRGGVGSMRLIPGVDVDALVSDPKLLVGFSDITALHQVWQGVGVPSLHGAVAGAHADGVRRLLMTDEPAVVGTQAGTLTAELTSGGRAEGSLAGGSLEQLARCVGVVDVPWDGRVLLLEANRASGLGMIERPLAQLALSGVLSRVAGVALGSFDEFTDHVDRGWTVLDVLRSWLDPLGVPVLGGLPLGHLEDTLTVPLGVPCTLDADAGTLTVSPGVR
>NC_012669.1|WP_012725093.1|49745_50270_-|GNAT-family-N-acetyltransferase
MIIRDATAADWPAIWPFLREIVAAGEAYCWPRDTSEEAARAWWTGKPGGRVFVAVDERVDDDVPVPLVVGTAELHPNQPAAGAHVANAGFMVDPAHAGRGIGRALAQHVLGAACQEGYRAMQFNAVVETNTAAVRLWRSLGFDVLATVPRAFDHPSAGPVGLHVMWRDLSTGPS
>NC_012669.1|WP_012725103.1|59500_61432_+|glycoside-hydrolase-family-127-protein
MTTTPAPPTHALVAAPATPRAAVAQHRPLDVRAVRLSSAGPLGAWQERNATATIPHCIEQLEASGVLDNFRRVIGESGAPYRGFVFADSDLYKVIEAVAWEIARSGTGRWDAWLDDVVGLVARTQDDTGYVMTWIQGLHPEKRFAELEWTHEMYVLGHLVQAAVALDRATCRADLLRIAERFVALVDRRFGPGREEGICGHPEIETALVELYRHTGDERHLALAQRMIDLRGRGLLKAGSFGPRYFQDHAPVREARTAVGHAVRQLYLDAGVTDVYLETGEPELLDAMRAQWVDAHERKMYLTGAFGSRHRDEAFGDAYELPSERAYAETCATIADLHWTWRLQLVGGTAAHADVVEREIHNALAASVDATGTRFFYSNPLQLRPDRHSEENAPRERAAWYSCACCPPNIARVVAQLAAYVASSTAETLWLHQYADAEIDLPEHLGTGVLEVRTDYPRSGVVDLAVRGTPAPGAHLALRVPAWSTRTLLDGVPVAAEDGYVRVDLADGAAWRLELDVTPRWTQAHPRVDAARGCLALERGPLVYCVEQADVPDGVAVDDLVVDPAAAPVERTRDDGALVLDVTCRTSGTPTQLYRTAAAGTPSSTTGDGAARRVPVTAVPFATWGNRAPGAMRVWLPAPESTD
>NC_012669.1|WP_012725104.1|61485_63141_+|extracellular-solute-binding-protein
MSRTTTARRRPGRTRAATGAAAGLAAASLVLTACTGGGGGEGDGGGEADGDSGGGETIQILVLKHPLTGPMADMGWVADLEEAADVTIEWEEVSADWDQKKSTMLAAGDIPDLIVGTNAITNSDFATFQGLFEDLSDDLDALPNVQGMFEALPETEIMATQPDGTIYGLPGYRRFWPQTATRQYVNQEWLDNLGLETPTTLDELFDVLVAFKDEDANGNGDPNDEIPMDWSPTGTGGFGFFQPTAFLGSFGLPISGGGGAGYFVEDGEVGNFLTDERYRDVVEFLHECYAAGLISEEVMTQDYSAYQSVGRGDGDTARVGFSWGWTSSDRFGAQLAPQYAATGPMVVEGVDPVWSFDSYGLNYGINQVTMSASTDVKDAALRVIDAFYDQDMSLQVLWGEFGQNIEQIDDSTYEVLPPADGTSDPSTWKWTTTLADNGPSWIRDDIDVTAPADLLESAEQEEPLGEALDNIDIENNVWPGELIKMDQADLSTVSLNNTNVLNIAMQKWAEWITGGGATDQWDDYVAQLEGSGLTQNIEIHQRYYDEYVENR
>NC_012669.1|WP_012725105.1|63247_64210_+|sugar-ABC-transporter-permease
MAVTLREVAPPSVLKAPRKRGRLSRHIGRYWQLWAMVAPAIAFIAVFMYVPMYGIQLAFREFNFATGITGGAWVGFTYFIQFFESPLFWTLMRNTVVISVSTLVVGFVTPIVLALIVNQVIGRRRKKFMQTATYLPHFISIVVIVGMLQVFLSPSSGLITRFLEALGITGVNFLGDTTAFVPAYVISEAWQHTGWNSIIYLAALASVSPQLYEAAKIDGANRMQIIRHVDFPALVPTMIVLLILNMGGVLATGFEKIFLMQNPLNLGISEVIATYVYKIGIIGNQFSYGTAIGLFNTLINFAFLVVTNQVAKRVSNTSLW
>NC_012669.1|WP_012725106.1|64224_65181_+|carbohydrate-ABC-transporter-permease
MALFSRPAATAGAPGGSLLSTLRPRTGGDLAFMIGLGLVCVVILFATLYPIYFVAIASVSDPTLVSTGRVSFWPRGINWFGYEQIFADARIWTGYRNTLLYTVVGTALNLVVTLPAAYALSRREFAPRRFLMLFFAFTMFFSGGLIPTYLLYRDLNLLDNWLVFVLPSAVNVYNLIIARAFFEHSLPEELFEAATLDGSTYFQFFFRMAVPLSMAIISVIGLYYLVQHWNDFFTGLVFVRDYSKQPLQIVLRDILISNQAFSGGAGGSGGSGGGSYAQQYADQIKYGVIIVSTLPVILLYPFLQRYFEKGVMIGSVKG
>NC_012669.1|WP_012725107.1|65180_65867_+|YesL-family-protein
MGAVLTWHQRLGRLGIQLLGAQLLWFAWTLRGGILLGAFPATAGVHAAARDVVLAHRRGAEPPSFRDMRDRVRRTWHDDFAVANRLGYGLALAWAFLVLDRRLVESVDLGGAAPVLAGLVTVLGIALGVVTVNAWVLQAHFTDGALALLRRGAVLAAARPAAALLASLGVAVVLCLYYLVPGLIPVFGVVAPAAVATASVWGSGVLTAPQSTPDATSGTPSSPLVGAR
>NC_012669.1|WP_012725108.1|65895_67686_+|glycoside-hydrolase-family-127-protein
MTAPETPPSRSAVSAVLRPLGYTGRVRITDGPLADRIADAAETYLGMSPDDVVHGFRLQAGLPAPGNPMTGWSSRTSQPTFGQWVSGLARLGVTAGVAEASQRAVDLVDAFAATVGDDGDARMGLYGYEKLVCGLADTALYAGHEDALALLGRTAEWASRTFERARPAASPNDFAGGRIGPASHARTMEWYTFAENLYRGWLAGADDAVREFASEWHYDAYWDRFLTPPPPGQPWDVPTWLHAYSHVNTFASAAAAYEVTGEVRYLDILRNAHTYLTTTQTYATGGYGPSELTLPEDGSLGRSIEWRTDTAEIVCGSWAAFKLSSALLKHTGEARYADWVEQLVYSGIGAVTPVRPGGRTPYYQDLRLGIATKLPHWDDWPCCSGTYLQAVSHLPDLVYFGDDDGGLAVALYVPSTVSWESAGSTVTLTQRTAFPVEDTSTITVGGSGRFRLRLRVPPWSEGFRVSVNGVAVDGVATPGDWFVLERDWADGDVVTVTLGAGLRVLPVDRWHPNRVAFAHGPVVLAQNADWTMPMSLPTPWEMVDLDAAFERGEGLRYAPVGVGTARLPLGELRPLADVPERVPYRVYADLDDPRIV
>NC_012669.1|WP_012725109.1|67870_68305_+|GNAT-family-N-acetyltransferase
MRVANLPEGYEASFDAARLDVERVHTWLSEDSYWARGRARETQEAAIAGSLNLGVYESATGEQVAYARIVTDGATFGWLCDVYVARRVRGLGIGTALVRLVREEGERLGLRRIVLATADAHAVYATAGFAPLEDPSMWMALQLR
>NC_012669.1|WP_012725110.1|68460_68988_-|AAA-family-ATPase
MPAAADAVLVTGTVGVGKTSVGESLSAYLEHAQVSHALIDTDAVRRMWPSPADDPFHLALELANVAAVAANYRGAGAQRFVVTGVLERGEDRARYAEALGAERLFVARLTADEHVVRRRLIARHDDDPDGLRWHLARRGELEAILDAAQLEDVLVDTTRLSPRDAAERIAASADW
>NC_012669.1|WP_012725111.1|69196_70729_+|alpha-N-arabinofuranosidase
MTTTARAVIDLDVPGPTISRHLYGHFAEHLGRCIYGGFWVGEDSDVPNEGGIRLDVVEALRALQIPNLRWPGGCFADEYHWRDGIGPRSERPRMVNTHWGDVVEDNSFGTHEFMALCELLGTEPYVNGNVGSGTVREMSEWVEYLTRPGTSPMADLRRANGRDEPWKVPFWGIGNEAWGCGGNMRAEAYADLARQYATFCRDHGDNSLYRIAAGASNGDYAWTEALMKAISCLGCTREPRGFFQGISFHYYTVPGPWHDKGSALEFDTDDYYTTMVKARGVEEIIRGHAAVMDVYDPGKTVGLVLDEWGTWWNVEPGTNPGFLYQQNTLRDALVASVHFDAFHRHADRLFMANIAQTVNVLQAMILTDPESGALVLTPTYHVFEMNTGHHDAAALDVHLTGAGTKAVGDGELELISASASVKGDTALVSLTNLDADGAASVVLDLRGRSVVASRGRILTADSLQTHNTPDAAAVAPSSFDAVSVTDDAFGHGLAVEIPAHSYVTLELDLA
>NC_012669.1|WP_012725112.1|70798_71659_-|helix-turn-helix-domain-containing-protein
MGMQRDDQGPDFELVLPGHLDVGAEYATHRPHGLPEWVVMLTITGRGEVLPEARRADVAASLAVPPGTAVALHPHTPQRYGTAPAPGTWELLWVHVRPPMAWLPLLDWPQHAPGIGVVRLSPVQAERAAAAMERAVAAHRAALPLAREFAVNAVEEALLWCALANPHRERTDATVRAFVEHVSAHLEEQHSVSSIAAALGLSGSHLAHVVKEATGDPVMAHVQRLRMDAACELLERTDLSVTQIAARVGYPDPLYFSRRFRAHTGDAPRDWRRARRPPRAEVVLRG

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Crispr_ID: NC_012669_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012669_2

490490-490593

Orphan

Consensus_repeat	Method
GGCTGGGCTGGGGGTGCGGGCTG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_012669_2

>merge|NC_012669|2|490490-490593|CRISPRCasFinder
GGCTGGGCGGGAGGTGCGGGCGGGGCGGGGGGTGCGGGCTGGGCTGGGGGTGCGGGCTGGGCTGCCGGCGCCTGCGGTGCGGTCTGGGCCGGCTGGGCGGGGGG

>NC_012669|2|2|490490-490593|CRISPRCasFinder
GGCTGGGCGGGAGGTGCGGGCGG	GGCGGGGGGTGCGGGCTG
GGCTGGGGGTGCGGGCTGGGCTG	CCGGCGCCTGCGGTGCG
GTCTGGGCCGGCTGGGCGGGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012669.1\|WP_012725482.1\|487640_488687_+\|DUF4838-domain-containing-protein	unknown	unknown	gnl\|CDD\|374379
NC_012669.1\|WP_012725493.1\|501037_501919_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
NC_012669.1\|WP_012725489.1\|496540_497119_+\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|334719
NC_012669.1\|WP_012725483.1\|488785_489130_+\|DUF488-family-protein	unknown	unknown	gnl\|CDD\|225730
NC_012669.1\|WP_012725495.1\|502975_503734_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NC_012669.1\|WP_012725492.1\|499524_500985_+\|lipase-maturation-factor-family-protein	unknown	unknown	gnl\|CDD\|369070
NC_012669.1\|WP_012725481.1\|486693_487644_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NC_012669.1\|WP_012725490.1\|497167_497509_+\|DUF1801-domain-containing-protein	unknown	unknown	gnl\|CDD\|378058
NC_012669.1\|WP_012725478.1\|484251_485091_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_012669.1\|WP_012725480.1\|485962_486697_+\|N-acetylmannosamine-6-phosphate-2-epimerase	unknown	unknown	gnl\|CDD\|234907
NC_012669.1\|WP_012725484.1\|489133_490450_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669
NC_012669.1\|WP_050761795.1\|485189_485966_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012669.1\|WP_012725487.1\|493105_495922_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226418
NC_012669.1\|WP_012725474.1\|479433_480198_-\|VIT1/CCC1-transporter-family-protein	unknown	unknown	gnl\|CDD\|153123
NC_012669.1\|WP_012725486.1\|491914_492997_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223510
NC_012669.1\|WP_012725488.1\|496102_496474_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|369571
NC_012669.1\|WP_012725494.1\|501911_502961_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|378117
NC_012669.1\|WP_012725491.1\|497733_499320_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NC_012669.1\|WP_012725477.1\|482821_484156_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NC_012669.1\|WP_012725476.1\|481854_482571_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099

Protein	Function_ID	Function_description	E-value
NC_012669.1\|WP_012725482.1\|487640_488687_+\|DUF4838-domain-containing-protein	gnl\|CDD\|374379	pfam16126, DUF4838, Domain of unknown function (DUF4838). This family consists of several uncharacterized proteins found in various Bacteroides and Chloroflexus species. The function of this family is unknown.	1.22504e-17
NC_012669.1\|WP_012725493.1\|501037_501919_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	7.77848e-83
NC_012669.1\|WP_012725489.1\|496540_497119_+\|dihydrofolate-reductase-family-protein	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	8.01449e-22
NC_012669.1\|WP_012725483.1\|488785_489130_+\|DUF488-family-protein	gnl\|CDD\|225730	COG3189, COG3189, Uncharacterized conserved protein [Function unknown].	1.32654e-44
NC_012669.1\|WP_012725495.1\|502975_503734_-\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	3.79027e-53
NC_012669.1\|WP_012725492.1\|499524_500985_+\|lipase-maturation-factor-family-protein	gnl\|CDD\|369070	pfam06762, LMF1, Lipase maturation factor. This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. The precise role of LMF1 in lipase folding has yet to be determined.	1.09451e-133
NC_012669.1\|WP_012725481.1\|486693_487644_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.15907e-47
NC_012669.1\|WP_012725490.1\|497167_497509_+\|DUF1801-domain-containing-protein	gnl\|CDD\|378058	pfam08818, DUF1801, Domain of unknown function (DU1801). This large family of bacterial proteins is uncharacterized. They contain a presumed domain about 110 amino acids in length.	4.9053e-12
NC_012669.1\|WP_012725478.1\|484251_485091_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.50827e-64
NC_012669.1\|WP_012725480.1\|485962_486697_+\|N-acetylmannosamine-6-phosphate-2-epimerase	gnl\|CDD\|234907	PRK01130, PRK01130, putative N-acetylmannosamine-6-phosphate 2-epimerase.	6.17343e-80
NC_012669.1\|WP_012725484.1\|489133_490450_-\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	0.0051216
NC_012669.1\|WP_050761795.1\|485189_485966_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.51069e-51
NC_012669.1\|WP_012725487.1\|493105_495922_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	3.87522e-31
NC_012669.1\|WP_012725474.1\|479433_480198_-\|VIT1/CCC1-transporter-family-protein	gnl\|CDD\|153123	cd02432, Nodulin-21_like_1, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	2.64195e-77
NC_012669.1\|WP_012725486.1\|491914_492997_-\|ATP-binding-protein	gnl\|CDD\|223510	COG0433, COG0433, HerA helicase [Replication, recombination, and repair].	2.25455e-23
NC_012669.1\|WP_012725488.1\|496102_496474_+\|cupin-domain-containing-protein	gnl\|CDD\|369571	pfam07883, Cupin_2, Cupin domain. This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).	6.41911e-11
NC_012669.1\|WP_012725494.1\|501911_502961_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|378117	pfam09084, NMT1, NMT1/THI5 like. This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.	1.12343e-69
NC_012669.1\|WP_012725491.1\|497733_499320_-\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	7.32085e-74
NC_012669.1\|WP_012725477.1\|482821_484156_+\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.97676e-38
NC_012669.1\|WP_012725476.1\|481854_482571_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	1.22402e-73

>NC_012669.1|WP_012725484.1|489133_490450_-|FtsX-like-permease-family-protein
MRQTVSLWWMLRRRSAGRSDPQGLTAVLATIAFAVTTAVVLVVLGGVLAFQERAVGADEFSDAAVYPILAYVAAGLLVIPIVTLGAAAARLAMARRDARLAALRLAGATTSQVGLLTLLEAASQAVVGAVLGVVGYLALIPLVAQLRFQNRTFELAELWVGPGYVALAVLAVVVLALGSAALSLRRVAITPLGVAARVTPKGLSWLRVVPVVVAGGAWIALLNSPYAGIGILLAVLLVGFAILNVVGPFVVWLIGRVTTARARSAATLIAGRRILDSPKTAWRTVGGVSLATFIAGMASVMSVLTGADADVVTRDMATGGFLTLGIAGLLAAVSAGVMQSGRIIDQRAEYRTLALTGAGLGVMRSAQLREIVIPLLVGMGVAAGFSLMFLVPMLGFSAVTDPSVVLQFAVSVLAAFALVIAGVLASRRVLRTVLTQEA
>NC_012669.1|WP_012725483.1|488785_489130_+|DUF488-family-protein
MTIATKRVYDDAAHGDGYRVLVDRLWPRGVSKERAHVDVWLRDVGPSDELRRWFHHEARLFEEFADRYRAELATNPAVETLRGIVRSHDVVTLVYSARDAEHNQAVVLRDYLSD
>NC_012669.1|WP_012725482.1|487640_488687_+|DUF4838-domain-containing-protein
MTTPPAPSPSAQPWFTTRGIVLTWDDVTSYDWPALAARAGLTTVSVHTSADGWASPAAHELRARCAELGLAIEEQQHALDRLLPRALFDTAPGMFRAGADGVRTPDANCCASSPDALDVIAEHAVTELERSATTTDRFYFWADDGGGWCHCPRCSELSPSDQSLLISNHVMRALRRVRPAAQLSHLAYQSTMAAPVATVPEKGVFLEFAPFFRTWEVPLSRTEANGPGWDPSVPDRSSPRAGRRDMLRVSHAEYLDRLDENLTVFPAATAQVLEYWLDVSLFSDWTMPAVELPWSDGVLEADLDTYGSRGIRHVTTFGAYMNGEYFASVGGVEPVERYGRALAAWRPR
>NC_012669.1|WP_012725481.1|486693_487644_+|ROK-family-protein
MTGTNDGAPVVAVDVGGTKIRSALVCGRDQVGEAGWRATPREGGAPVLQAVRAEVEALVASSAVRPRGVGLACAGTVDRDRGVVVAAGSTLADWSGTRLRRALEPGLGLPVVVDNDCNAFASGVAADDGGSLLAVMVGTGLGAGLVIDGELHRGRRFTAGEIAHMAAGESVGPWCGCGLPGHLEGIASGSGIDRYHAHLTGQGAVGVGVVAQRYRHGDPTAAQVVTAAGAALGGALAGLAVALDLDRVVVGGGVIDAVPEVGEIVANRFDHALPPTLQRDVRLEVSPDSATAVLRGIARQVADTTARRPGPEGHAR
>NC_012669.1|WP_012725480.1|485962_486697_+|N-acetylmannosamine-6-phosphate-2-epimerase
MTTPSLERLRGGLVVSCQARQGEPLDAPDHIVALARSAVLGGAVGVRIDGSENISAVRRATDVPIIGIKKVADRERPRITPTEADVIEVLDAGADIVAVDASMQYRTDVAALHRIVRRIRAHGTATVMADISTRSEAERAWEAGVDVVGTTLYGHTPQTSATVGPGLELVAELVPLGMRVIVEGRVTEPAEVEAAFTLGAWSVVVGGAITSPIDLTRRFAAVTPRRSGDHEPAEAGRGTSGGPG
>NC_012669.1|WP_050761795.1|485189_485966_+|carbohydrate-ABC-transporter-permease
MLLIAVVYLFPLFFLLNTALKAPGEFNRDPMGIVDAPALENFSAAWRQGDFGSLVANSVVYAMVSATVSTVLSVFIAFPVARNYVRWSRFFRVLFVISLFLPNALVAQFQLVLQLGLYDTRLGYMLLMTAGLGLGPLLVMGYLRSLPRELDEAAALDGCGYLRYVLTFVFPLCRPVVITVFLLQVIGVWNDIIGATIYLASPELRTISLGLFSFYGQYGNNQWELLSAATLIVAGPLILLFLLAQRFFVSGAIGGALK
>NC_012669.1|WP_012725478.1|484251_485091_+|sugar-ABC-transporter-permease
MAPGLLLFALFGLIPAVAVIGMSFTNISGMPNVPWEWTGLDNYRRFFSAGAAAANMSVIVRTIVFAFSVTVILNALALFIAIILNRRLPGAAIARSIVFMPVAFGVTVVGLVWSLMLNPTGGPAASLWEIFGARSAFLGDPRLAFPLIILVQIWAAIGTTMMIYHAGLQAVPDDLYEAATVDGANAAQRVRHVTIPMVAPSITANMIISIVGSLQTYQIIYVLTGDRPTTSVLAMQIFSLGFGSSEQGYAAAVSMVQFVLVAVVALVFLAYLRRRETQL
>NC_012669.1|WP_012725477.1|482821_484156_+|extracellular-solute-binding-protein
MKRTRRRVVAALALVSATSLVASACSSGSEGGEGGEEEATLRIFVHANPPTDAGFEAINAMFEEQHPGVTVELTTAQGADFFTVRNTRLTAENVDITEGSSSGGTRLLPDWVQDQTESDWVVGLQAGTWVDLTDQPFLDNFSPEIMEAYEYEGRSYAVPTGTSLVGGVYYNTALFEEHGLELPTTWDELLHVIDVFEAAGVAPFIMGGKDVWPAGAPMYGLVQSLFPDSAALDQGLWEGDVQLTDPEVVTLMERLATIYAHTYPQWEGIDYSSVPARFAAGDAAMMPDGGWSIPAIQEADPDFEFGYFPLPGSDNAADNDTIAGKLEFSLSIPTSSDNQELAMEWLALYSDPEVYSDFIVASGFGTAQPDVELGPVLQGVQQYLPEGGFTPSWDQVFHGNRYAGPLAANPFAFDNVAPVGTYTDMAELTARMNDDWQVGLDSLP
>NC_012669.1|WP_012725476.1|481854_482571_-|GntR-family-transcriptional-regulator
MTTTQAEDGKAERVRRHLEQLIDTSLQPHDRLPPERLLAAQLDVSRMTVRQALDSLEAEKRVYRVQGSGNYVAERVIEKTIRLTSFTEDMRERGMTPGARLVTSGTEHAGPEVGARLGLSPADAVVRINRIRLADGEPVCLEAVHISEKRVPGLLEEDLSGSLYDLLTTRYDIAVSTAQQRIGATVVDQADAKLLEVAPFSPALVIERLTLDQHRRPLEYTRSLYRADRYSFLIDIER
>NC_012669.1|WP_012725474.1|479433_480198_-|VIT1/CCC1-transporter-family-protein
MTTLHADHDLLSPTSASSSEARSESGEPLAQGLAARLNWLRAGVLGANDGIVSVAAVVVGVAGATSSTPAIVVAGAAALVGGALSMALGEYVSVSSARDSQHAVIARARRNATDPERGLADVAAAYERRGVSAATARQVAAELVAHDADAAHLEAAGIDEDDVVSPWHAAGASALAFVLGALLPFLTVLLVPAPVRIVATVGAVLVALAVLGAAGARLGRAPMGRPTARVVLGGALALAVTYGIGSLLGVTGVV
>NC_012669.1|WP_012725486.1|491914_492997_-|ATP-binding-protein
MLQLPVGTHAGSAEPFSLDGARFNRHTFWCGQSGSGKTYALGVVLERLLLDTGLPMLVLDPNSDFVSFGQPAPSAPEDVAQQIRERDVRVFRPRGEGGEPLLVRFVAMDLASRAAVLRLDPIADAEEFNAMRRLQDDSGPQDADALEAALRQSSEPGARPLLLRVQNLGTLGWDVWARGRVSVESVIEERPAATVLDLGGFDEPEESTTAALAVLDRLWALRAERKPLLIVIDEAHNLCPPDPLTPVRRAITERIIQIAAEGRKYGLWLLLSTQRPSKIHPQVLSQCDNLCLMKLNGPLDLAHLGEFFGAVPPDLLQRAPSFRQGQALFAGGFAATPTIAQLAERFTLEGGSDVTVPLRG
>NC_012669.1|WP_012725487.1|493105_495922_-|LuxR-family-transcriptional-regulator
MPTLPAEAVTPREHDVLVGVAQHLTNAQIARDLHLSVRTVETHVSALLRKLGVASRRDLAATAAGLTARPDGSARPADHDGPRRVPGPHRHSLRSAGTPSGVIGLPAPRTSFVGRRAEVDAATRLAQESRLTTIVGPGGAGKTRLAIAATTAVAPAFPSGGAYVDLVPTRPGHVDEAVATALGVTEGPGQTLRQALAAALRGRVLLVLDNAEHLVDDVTGLVEDLLDACPGLSIVATSRERLAVAGETVLLLGPLHVADEAVVLFTERARDGDPAFAAEPADVEDLCRRLDCSPLAIELAAARVASLGVAGLRAGLADQLRVVAASRGGHERHRSLRAVIEWSHRLLAADERYVLARTSLFAGSFTLSSAAALCPDLAPGTVADVVGRLGDKSLVHRAEDAARWTLLASVRQFAREQLDASDDAGRTVGLYRTWAASTAADLRRRMASGADWWDALELVQDDLRACARLEDPSVPTRDGGGRALPGGGGGGATRHALVRDLARLTTARGCVGEARGHFLAAARLAPSGAAAARDLADAASCAHLLTHAKDAYDLLLEAAQVAGADGGVRADALAGAVVVARRFLGSGFERPVERPVLEGMFAEADRIAAGDDDGASRRVAPVAVARAWLSGDGAQLVDAGAAAHAVAQVRETGDVVLLSAALDASSTAWAASGRPDESHRLAGERLDLVALMDRSDPGALVEIVDAHRGASAYAIATGAVAEALEIGERAAAETSLAAYHRRSLDWLVVAAALAGDHARAVDLAERSWSAFLDAGRPRTSTFGVPMLAGSLAAGLAGDSGGADRWRERAREGTGLADFHASPNLAPWDAFVRARLALHTGELDGVLASVGAEFSPGRFDGYAAAVAAEIAVVAGSPNVEDRLETAARHAGRNRWVAASLQRSRARLTGDTDALHDAAELFGNLGAAFERERTLALVGT
>NC_012669.1|WP_012725488.1|496102_496474_+|cupin-domain-containing-protein
MLIVAKEADLRIGTGRTVRFEGEGYGSGISYFHVENEPGQGPDAHVHPYSETWVVLAGTAHMRTADGETLAHAGDVVVVGPDTAHAFRAAGTETLRMMCIHASPRIQQEFLADDESERLAVAF
>NC_012669.1|WP_012725489.1|496540_497119_+|dihydrofolate-reductase-family-protein
MSTRKIVVGQFVSLDGVVESPQTWHFPYLNDEMGAALGQLYAEADTLLLGRATYEEFAAVWPHQTGAMADAINGVRKVVVSTTLVDPDWQNTTVVAHDVLREVARLKESPGRDIAVTGSITLTQALLAAGLVDELRLLVHPIVLGAGRRLFADGGAFADGEAPGRGATRVPLALASSTTFATGVLDLTYRPA
>NC_012669.1|WP_012725490.1|497167_497509_+|DUF1801-domain-containing-protein
MTTIDELVAGLDDERRETATRLCTLLDSALPEASARVYHGHPVWLDEARPVAGFKPFPRYVTFMIWNAEPIDDTSGTLVPGARMSTVKYAAAEEIDEALVRDWLARSAGVRGA
>NC_012669.1|WP_012725491.1|497733_499320_-|MFS-transporter
MTTTQPTSRRDVPARAGAREWTALGVLALPALLVSIDVFVLLLALPSLSSDLGATATQQLWILDVYGFMLAGFMLTAGTLGDRIGRRRLLLIGGAAFGVASIVAALSTGPLMLIVARGALGIAGATLAPSTLALISNLFRDPAQRAQAIGVWLVCFMGGAALGPVVGGIVLEHFWWGAAFLLGVPVMVLLLILGPLLLPEYRDATAGRIDLASVALSLAAILPFVFGVKELARAGWAPLPALGLTAGIAFGVAFARRQLRLTDPVLDLRLFRNHRFSAGVGGMLLIASTGVTMYLVTQYLQLVRGMGPLEAGIATLPGVVASITGFLVSPLLARRVRPGVLIASGMAVAASGVVVLTQAGVGGPLTFAVLGYALFQLGCGPMVTLGTDLVVGSAPPEKAGSAAAASESSGELGYGLGIAVVGSVAAAVYASRLSASTTASLSAADEAAARGSLAGAVEVARTLGDDALLDAAREAFLAGMRAGLVGVVGVMVGVAVIGLGALRHVPSLRQGHSSGASAPQPAPAGEDS
>NC_012669.1|WP_012725492.1|499524_500985_+|lipase-maturation-factor-family-protein
MEWFAAGDYTIAREILQRGVAAVFVLAFVAVLRQFPALLGSGGLLPVPRYLARLERVTRRSRVLTLFWWRYSDALLRTVGWVGLLLALSLVVGLPQAGPWWVPLVAFLLLYVLYLSIVEVGQTFYAFGWETLLLEAGFIVAFLGSDDVAPPVLVLLAARWLVFRVEFGAGLIKMRGDPAWRDLTALYYHHETQPMPGPLSWHAHHAPRWWHRVEVAGNHVTQLGIVWLLFAPQPVASIAAGVIVLTQAWLVVTGNFAWLNALTMVLAASAISDSSWRWLLPFLPEPADDGVASGANIGFGVVVAAFFVLTVVLSYWPVRNLLSQRQLMNASFNRFRLGNTYGAFGSITRRRREVVVAGTLAAEPTEDDWREYGFRGKPGEVRRRPPQVAPYHLRLDWLMWFLALGGRDEAWFVAFLRRLLEADPATLRLLRHDPFDGVAPRFVRARVYRYRYTTRAERRVSGDTWVRVSAGVLVPPVALGDLPPTP
>NC_012669.1|WP_012725493.1|501037_501919_-|ABC-transporter-ATP-binding-protein
MLEPLLAVGGLGVRFDAVEAVRGATFDVGHGEFVAVIGPSGCGKSTVLRALAGLLPAGARFDGAIDVPHEGGRPDVAWLPQRDALLPWRRAWANALVGARIAGVPDAETRAAELFDRFGLAGFERAWPHELSGGMRQRLALLRTVLAGRRVLLLDEPFGALDALTRRSMNDWLAGLHLAGHADDGGASGVGRLAVGPGSSRLGAATADGAAAAGAVVLVTHDVDEALRLADRVLVMSARPGRIVREVAVPGSAVSRDDAHPELRTELLAALDHDSDPSGRFRPSGAPESTARV
>NC_012669.1|WP_012725494.1|501911_502961_-|ABC-transporter-substrate-binding-protein
MTLTHPGRAHRVARRSRAVPAAVVALALCATLAACGGIGGGASADGEAQRLRLVLDWTPNTNHSGIYLAAERGWYTDAGLDVEIVEPGETSGLQLVAAGQAEVALSVAESLVPAREQGADVVSIAAVIPENTSSLISLTADGITRPADLAGRRYGTYGSALEAALIERLVACDGGDPAAVEMTPLASDDFRIGLTQDQFDVGWVFEGWDTIRLRDVDGLDVTTIPFADHTDCIPNWYTPLVATSQELVDSDPELLRAFLEATARGYEAATADPEAAADALLAAAPALDAELVRLSAAYLAPRYSSTPEQWGAQDSATWDAFVEFLVSEGLAAPGTDPDALWTDELLPDA
>NC_012669.1|WP_012725495.1|502975_503734_-|ABC-transporter-permease
MRRTRRVLLPSLVLAALVAVWELAVRAAELPPFVLPAPTAVLAAGVRLHDELGAHLATTLTEAGLGLAAGAFAGAGIAVVVALVPVIGDAVLPLVVLTQTVPTVVLAPLLILWAGFGIGGKVVLVALTTFFPVMVATSSAMARADAELADMVRGLGGGRRDELALVRLPAALPGALAGLRIAATYAIGAAVVAEYLAGASGIGVFIQHSRKAYAVDQILVGVLLVGLVTGALVLAVDALSRRLVPWQRPDLS

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Crispr_ID: NC_012669_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012669_3

497524-497623

Orphan

Consensus_repeat	Method
CTGGCCCACCGGCAGGGGGCGGTCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012669_3

>merge|NC_012669|3|497524-497623|CRISPRCasFinder
CTGGCCCACCGGCAGGGGGCGGTCGGTGGGCCAGACGAGGGGCGGAGGGGAAACCTCTACCCCTGGATTGGTGACTGGCCCGCCGGCAGGGGGCGGTCGG

>NC_012669|3|3|497524-497623|CRISPRCasFinder
CTGGCCCACCGGCAGGGGGCGGTCGG	TGGGCCAGACGAGGGGCGGAGGGGAAACCTCTACCCCTGGATTGGTGA
CTGGCCCGCCGGCAGGGGGCGGTCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012669.1\|WP_012725482.1\|487640_488687_+\|DUF4838-domain-containing-protein	unknown	unknown	gnl\|CDD\|374379
NC_012669.1\|WP_050761570.1\|506169_507993_-\|DUF4012-domain-containing-protein	unknown	unknown	gnl\|CDD\|379067
NC_012669.1\|WP_012725489.1\|496540_497119_+\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|334719
NC_012669.1\|WP_012725497.1\|504288_505167_-\|DUF4111-domain-containing-protein	unknown	unknown	gnl\|CDD\|184296
NC_012669.1\|WP_012725483.1\|488785_489130_+\|DUF488-family-protein	unknown	unknown	gnl\|CDD\|225730
NC_012669.1\|WP_012725500.1\|508358_510959_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NC_012669.1\|WP_012725496.1\|503730_504024_-\|thiamine-binding-protein	unknown	unknown	gnl\|CDD\|376658
NC_012669.1\|WP_012725492.1\|499524_500985_+\|lipase-maturation-factor-family-protein	unknown	unknown	gnl\|CDD\|369070
NC_012669.1\|WP_012725493.1\|501037_501919_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
NC_012669.1\|WP_012725490.1\|497167_497509_+\|DUF1801-domain-containing-protein	unknown	unknown	gnl\|CDD\|378058
NC_012669.1\|WP_144016685.1\|490446_491373_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213222
NC_012669.1\|WP_012725484.1\|489133_490450_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669
NC_012669.1\|WP_050761567.1\|505262_506003_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|366278
NC_012669.1\|WP_012725495.1\|502975_503734_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NC_012669.1\|WP_012725481.1\|486693_487644_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NC_012669.1\|WP_012725486.1\|491914_492997_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223510
NC_012669.1\|WP_012725488.1\|496102_496474_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|369571
NC_012669.1\|WP_012725491.1\|497733_499320_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NC_012669.1\|WP_012725487.1\|493105_495922_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226418
NC_012669.1\|WP_012725494.1\|501911_502961_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|378117

Protein	Function_ID	Function_description	E-value
NC_012669.1\|WP_012725482.1\|487640_488687_+\|DUF4838-domain-containing-protein	gnl\|CDD\|374379	pfam16126, DUF4838, Domain of unknown function (DUF4838). This family consists of several uncharacterized proteins found in various Bacteroides and Chloroflexus species. The function of this family is unknown.	1.22504e-17
NC_012669.1\|WP_050761570.1\|506169_507993_-\|DUF4012-domain-containing-protein	gnl\|CDD\|379067	pfam13196, DUF4012, Protein of unknown function (DUF4012). This is a family of uncharacterized proteins found in archaea and bacteria.	4.2939e-54
NC_012669.1\|WP_012725489.1\|496540_497119_+\|dihydrofolate-reductase-family-protein	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	8.01449e-22
NC_012669.1\|WP_012725497.1\|504288_505167_-\|DUF4111-domain-containing-protein	gnl\|CDD\|184296	PRK13746, PRK13746, aminoglycoside resistance protein; Provisional.	3.76717e-17
NC_012669.1\|WP_012725483.1\|488785_489130_+\|DUF488-family-protein	gnl\|CDD\|225730	COG3189, COG3189, Uncharacterized conserved protein [Function unknown].	1.32654e-44
NC_012669.1\|WP_012725500.1\|508358_510959_-\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	3.54102e-22
NC_012669.1\|WP_012725496.1\|503730_504024_-\|thiamine-binding-protein	gnl\|CDD\|376658	pfam01910, Thiamine_BP, Thiamine-binding protein. The crystal structure of two of these members shows that this domain has a ferredoxin like fold and is likely to exists as at least homodimers. Sulphate ions are are located at the dimer interfaces, which are thought to confer additional stability. Although the function of this domain remains to be identified, its structure suggests a role in protein-protein interactions possibly regulated by the binding of small-molecule ligands. Solution of the structure of the hyperthermophilic anaerobic Thermotoga maritima sequence, UniProtKB:Q9WYV6, shows that this has a beta-alpha-beta-beta-alpha-beta ferredoxin-like fold and assembles as a homotetramer. It was possible to identify a pocket in each monmer that bound an unidentified ligand. It was also found that it bound charged thiamine though not hydroxymethyl pyrimidine. It is proposed that it is transporting charged thiamine around the cytoplasm. Under oxidative conditions this bacterium is under stress, and the transcriiptional unit within which this protein is expressed is up-regulated in these conditions, suggesting that the chelation of cytoplasmic thaimine is part of the response mechanism to such oxidatvie stress, which is mediated by this family.	2.58034e-19
NC_012669.1\|WP_012725492.1\|499524_500985_+\|lipase-maturation-factor-family-protein	gnl\|CDD\|369070	pfam06762, LMF1, Lipase maturation factor. This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. The precise role of LMF1 in lipase folding has yet to be determined.	1.09451e-133
NC_012669.1\|WP_012725493.1\|501037_501919_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	7.77848e-83
NC_012669.1\|WP_012725490.1\|497167_497509_+\|DUF1801-domain-containing-protein	gnl\|CDD\|378058	pfam08818, DUF1801, Domain of unknown function (DU1801). This large family of bacterial proteins is uncharacterized. They contain a presumed domain about 110 amino acids in length.	4.9053e-12
NC_012669.1\|WP_144016685.1\|490446_491373_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	7.17779e-103
NC_012669.1\|WP_012725484.1\|489133_490450_-\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	0.0051216
NC_012669.1\|WP_050761567.1\|505262_506003_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|366278	pfam00746, Gram_pos_anchor, LPXTG cell wall anchor motif.	3.07254e-05
NC_012669.1\|WP_012725495.1\|502975_503734_-\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	3.79027e-53
NC_012669.1\|WP_012725481.1\|486693_487644_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.15907e-47
NC_012669.1\|WP_012725486.1\|491914_492997_-\|ATP-binding-protein	gnl\|CDD\|223510	COG0433, COG0433, HerA helicase [Replication, recombination, and repair].	2.25455e-23
NC_012669.1\|WP_012725488.1\|496102_496474_+\|cupin-domain-containing-protein	gnl\|CDD\|369571	pfam07883, Cupin_2, Cupin domain. This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).	6.41911e-11
NC_012669.1\|WP_012725491.1\|497733_499320_-\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	7.32085e-74
NC_012669.1\|WP_012725487.1\|493105_495922_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	3.87522e-31
NC_012669.1\|WP_012725494.1\|501911_502961_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|378117	pfam09084, NMT1, NMT1/THI5 like. This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.	1.12343e-69

>NC_012669.1|WP_012725490.1|497167_497509_+|DUF1801-domain-containing-protein
MTTIDELVAGLDDERRETATRLCTLLDSALPEASARVYHGHPVWLDEARPVAGFKPFPRYVTFMIWNAEPIDDTSGTLVPGARMSTVKYAAAEEIDEALVRDWLARSAGVRGA
>NC_012669.1|WP_012725489.1|496540_497119_+|dihydrofolate-reductase-family-protein
MSTRKIVVGQFVSLDGVVESPQTWHFPYLNDEMGAALGQLYAEADTLLLGRATYEEFAAVWPHQTGAMADAINGVRKVVVSTTLVDPDWQNTTVVAHDVLREVARLKESPGRDIAVTGSITLTQALLAAGLVDELRLLVHPIVLGAGRRLFADGGAFADGEAPGRGATRVPLALASSTTFATGVLDLTYRPA
>NC_012669.1|WP_012725488.1|496102_496474_+|cupin-domain-containing-protein
MLIVAKEADLRIGTGRTVRFEGEGYGSGISYFHVENEPGQGPDAHVHPYSETWVVLAGTAHMRTADGETLAHAGDVVVVGPDTAHAFRAAGTETLRMMCIHASPRIQQEFLADDESERLAVAF
>NC_012669.1|WP_012725487.1|493105_495922_-|LuxR-family-transcriptional-regulator
MPTLPAEAVTPREHDVLVGVAQHLTNAQIARDLHLSVRTVETHVSALLRKLGVASRRDLAATAAGLTARPDGSARPADHDGPRRVPGPHRHSLRSAGTPSGVIGLPAPRTSFVGRRAEVDAATRLAQESRLTTIVGPGGAGKTRLAIAATTAVAPAFPSGGAYVDLVPTRPGHVDEAVATALGVTEGPGQTLRQALAAALRGRVLLVLDNAEHLVDDVTGLVEDLLDACPGLSIVATSRERLAVAGETVLLLGPLHVADEAVVLFTERARDGDPAFAAEPADVEDLCRRLDCSPLAIELAAARVASLGVAGLRAGLADQLRVVAASRGGHERHRSLRAVIEWSHRLLAADERYVLARTSLFAGSFTLSSAAALCPDLAPGTVADVVGRLGDKSLVHRAEDAARWTLLASVRQFAREQLDASDDAGRTVGLYRTWAASTAADLRRRMASGADWWDALELVQDDLRACARLEDPSVPTRDGGGRALPGGGGGGATRHALVRDLARLTTARGCVGEARGHFLAAARLAPSGAAAARDLADAASCAHLLTHAKDAYDLLLEAAQVAGADGGVRADALAGAVVVARRFLGSGFERPVERPVLEGMFAEADRIAAGDDDGASRRVAPVAVARAWLSGDGAQLVDAGAAAHAVAQVRETGDVVLLSAALDASSTAWAASGRPDESHRLAGERLDLVALMDRSDPGALVEIVDAHRGASAYAIATGAVAEALEIGERAAAETSLAAYHRRSLDWLVVAAALAGDHARAVDLAERSWSAFLDAGRPRTSTFGVPMLAGSLAAGLAGDSGGADRWRERAREGTGLADFHASPNLAPWDAFVRARLALHTGELDGVLASVGAEFSPGRFDGYAAAVAAEIAVVAGSPNVEDRLETAARHAGRNRWVAASLQRSRARLTGDTDALHDAAELFGNLGAAFERERTLALVGT
>NC_012669.1|WP_012725486.1|491914_492997_-|ATP-binding-protein
MLQLPVGTHAGSAEPFSLDGARFNRHTFWCGQSGSGKTYALGVVLERLLLDTGLPMLVLDPNSDFVSFGQPAPSAPEDVAQQIRERDVRVFRPRGEGGEPLLVRFVAMDLASRAAVLRLDPIADAEEFNAMRRLQDDSGPQDADALEAALRQSSEPGARPLLLRVQNLGTLGWDVWARGRVSVESVIEERPAATVLDLGGFDEPEESTTAALAVLDRLWALRAERKPLLIVIDEAHNLCPPDPLTPVRRAITERIIQIAAEGRKYGLWLLLSTQRPSKIHPQVLSQCDNLCLMKLNGPLDLAHLGEFFGAVPPDLLQRAPSFRQGQALFAGGFAATPTIAQLAERFTLEGGSDVTVPLRG
>NC_012669.1|WP_144016685.1|490446_491373_-|ATP-binding-cassette-domain-containing-protein
MDDMTDASPLVARRLAKTYGDAQNPTVALDGVDLTISPGQSVAIMGPSGSGKTTLLHCLAGILAPSGGTVTWRGAELGGLSDAQRTALRRDDFGFVFQSGQLLPELPAEENAALPLLLAGSERPHAVSRARQWLGYLGLAGMEQRRPGELSGGQAQRVAIARALVGNPGVVFADEPTGALDRTTGYEVMHALTTATRASGAALVVVTHDPEVARWCSRTISMRDGRIIGEAVQEAAGGQAAAAPVAPSAQPMVAPTQQPAPPAQPAQTAPQAPAAQPAPPAQPAPPAPPAPPAQPVAPAGTTPWGGAR
>NC_012669.1|WP_012725484.1|489133_490450_-|FtsX-like-permease-family-protein
MRQTVSLWWMLRRRSAGRSDPQGLTAVLATIAFAVTTAVVLVVLGGVLAFQERAVGADEFSDAAVYPILAYVAAGLLVIPIVTLGAAAARLAMARRDARLAALRLAGATTSQVGLLTLLEAASQAVVGAVLGVVGYLALIPLVAQLRFQNRTFELAELWVGPGYVALAVLAVVVLALGSAALSLRRVAITPLGVAARVTPKGLSWLRVVPVVVAGGAWIALLNSPYAGIGILLAVLLVGFAILNVVGPFVVWLIGRVTTARARSAATLIAGRRILDSPKTAWRTVGGVSLATFIAGMASVMSVLTGADADVVTRDMATGGFLTLGIAGLLAAVSAGVMQSGRIIDQRAEYRTLALTGAGLGVMRSAQLREIVIPLLVGMGVAAGFSLMFLVPMLGFSAVTDPSVVLQFAVSVLAAFALVIAGVLASRRVLRTVLTQEA
>NC_012669.1|WP_012725483.1|488785_489130_+|DUF488-family-protein
MTIATKRVYDDAAHGDGYRVLVDRLWPRGVSKERAHVDVWLRDVGPSDELRRWFHHEARLFEEFADRYRAELATNPAVETLRGIVRSHDVVTLVYSARDAEHNQAVVLRDYLSD
>NC_012669.1|WP_012725482.1|487640_488687_+|DUF4838-domain-containing-protein
MTTPPAPSPSAQPWFTTRGIVLTWDDVTSYDWPALAARAGLTTVSVHTSADGWASPAAHELRARCAELGLAIEEQQHALDRLLPRALFDTAPGMFRAGADGVRTPDANCCASSPDALDVIAEHAVTELERSATTTDRFYFWADDGGGWCHCPRCSELSPSDQSLLISNHVMRALRRVRPAAQLSHLAYQSTMAAPVATVPEKGVFLEFAPFFRTWEVPLSRTEANGPGWDPSVPDRSSPRAGRRDMLRVSHAEYLDRLDENLTVFPAATAQVLEYWLDVSLFSDWTMPAVELPWSDGVLEADLDTYGSRGIRHVTTFGAYMNGEYFASVGGVEPVERYGRALAAWRPR
>NC_012669.1|WP_012725481.1|486693_487644_+|ROK-family-protein
MTGTNDGAPVVAVDVGGTKIRSALVCGRDQVGEAGWRATPREGGAPVLQAVRAEVEALVASSAVRPRGVGLACAGTVDRDRGVVVAAGSTLADWSGTRLRRALEPGLGLPVVVDNDCNAFASGVAADDGGSLLAVMVGTGLGAGLVIDGELHRGRRFTAGEIAHMAAGESVGPWCGCGLPGHLEGIASGSGIDRYHAHLTGQGAVGVGVVAQRYRHGDPTAAQVVTAAGAALGGALAGLAVALDLDRVVVGGGVIDAVPEVGEIVANRFDHALPPTLQRDVRLEVSPDSATAVLRGIARQVADTTARRPGPEGHAR
>NC_012669.1|WP_012725491.1|497733_499320_-|MFS-transporter
MTTTQPTSRRDVPARAGAREWTALGVLALPALLVSIDVFVLLLALPSLSSDLGATATQQLWILDVYGFMLAGFMLTAGTLGDRIGRRRLLLIGGAAFGVASIVAALSTGPLMLIVARGALGIAGATLAPSTLALISNLFRDPAQRAQAIGVWLVCFMGGAALGPVVGGIVLEHFWWGAAFLLGVPVMVLLLILGPLLLPEYRDATAGRIDLASVALSLAAILPFVFGVKELARAGWAPLPALGLTAGIAFGVAFARRQLRLTDPVLDLRLFRNHRFSAGVGGMLLIASTGVTMYLVTQYLQLVRGMGPLEAGIATLPGVVASITGFLVSPLLARRVRPGVLIASGMAVAASGVVVLTQAGVGGPLTFAVLGYALFQLGCGPMVTLGTDLVVGSAPPEKAGSAAAASESSGELGYGLGIAVVGSVAAAVYASRLSASTTASLSAADEAAARGSLAGAVEVARTLGDDALLDAAREAFLAGMRAGLVGVVGVMVGVAVIGLGALRHVPSLRQGHSSGASAPQPAPAGEDS
>NC_012669.1|WP_012725492.1|499524_500985_+|lipase-maturation-factor-family-protein
MEWFAAGDYTIAREILQRGVAAVFVLAFVAVLRQFPALLGSGGLLPVPRYLARLERVTRRSRVLTLFWWRYSDALLRTVGWVGLLLALSLVVGLPQAGPWWVPLVAFLLLYVLYLSIVEVGQTFYAFGWETLLLEAGFIVAFLGSDDVAPPVLVLLAARWLVFRVEFGAGLIKMRGDPAWRDLTALYYHHETQPMPGPLSWHAHHAPRWWHRVEVAGNHVTQLGIVWLLFAPQPVASIAAGVIVLTQAWLVVTGNFAWLNALTMVLAASAISDSSWRWLLPFLPEPADDGVASGANIGFGVVVAAFFVLTVVLSYWPVRNLLSQRQLMNASFNRFRLGNTYGAFGSITRRRREVVVAGTLAAEPTEDDWREYGFRGKPGEVRRRPPQVAPYHLRLDWLMWFLALGGRDEAWFVAFLRRLLEADPATLRLLRHDPFDGVAPRFVRARVYRYRYTTRAERRVSGDTWVRVSAGVLVPPVALGDLPPTP
>NC_012669.1|WP_012725493.1|501037_501919_-|ABC-transporter-ATP-binding-protein
MLEPLLAVGGLGVRFDAVEAVRGATFDVGHGEFVAVIGPSGCGKSTVLRALAGLLPAGARFDGAIDVPHEGGRPDVAWLPQRDALLPWRRAWANALVGARIAGVPDAETRAAELFDRFGLAGFERAWPHELSGGMRQRLALLRTVLAGRRVLLLDEPFGALDALTRRSMNDWLAGLHLAGHADDGGASGVGRLAVGPGSSRLGAATADGAAAAGAVVLVTHDVDEALRLADRVLVMSARPGRIVREVAVPGSAVSRDDAHPELRTELLAALDHDSDPSGRFRPSGAPESTARV
>NC_012669.1|WP_012725494.1|501911_502961_-|ABC-transporter-substrate-binding-protein
MTLTHPGRAHRVARRSRAVPAAVVALALCATLAACGGIGGGASADGEAQRLRLVLDWTPNTNHSGIYLAAERGWYTDAGLDVEIVEPGETSGLQLVAAGQAEVALSVAESLVPAREQGADVVSIAAVIPENTSSLISLTADGITRPADLAGRRYGTYGSALEAALIERLVACDGGDPAAVEMTPLASDDFRIGLTQDQFDVGWVFEGWDTIRLRDVDGLDVTTIPFADHTDCIPNWYTPLVATSQELVDSDPELLRAFLEATARGYEAATADPEAAADALLAAAPALDAELVRLSAAYLAPRYSSTPEQWGAQDSATWDAFVEFLVSEGLAAPGTDPDALWTDELLPDA
>NC_012669.1|WP_012725495.1|502975_503734_-|ABC-transporter-permease
MRRTRRVLLPSLVLAALVAVWELAVRAAELPPFVLPAPTAVLAAGVRLHDELGAHLATTLTEAGLGLAAGAFAGAGIAVVVALVPVIGDAVLPLVVLTQTVPTVVLAPLLILWAGFGIGGKVVLVALTTFFPVMVATSSAMARADAELADMVRGLGGGRRDELALVRLPAALPGALAGLRIAATYAIGAAVVAEYLAGASGIGVFIQHSRKAYAVDQILVGVLLVGLVTGALVLAVDALSRRLVPWQRPDLS
>NC_012669.1|WP_012725496.1|503730_504024_-|thiamine-binding-protein
MLVEIHVSPRPSGTPEQKYAHVDAAIAVIAASGLTYEVHALGTVIEGPPDRIWSLVRDVHEATFAAGADSTMTTIRLAQGKDDAGPTIADLVTKFRA
>NC_012669.1|WP_012725497.1|504288_505167_-|DUF4111-domain-containing-protein
MTSAALTPHPPDRAQSWATADPDIRSYVSAAVGLFTDELGDGVAGVVLHGSLAAGCFYRAKADLDLLVVVADPIEPTSRARLSRGLAQLAGTRPILGDLEVSAITAAAAATFRHPSPYELHYSAAWRDAVLEGRVDVAAQQVDGDLAGHVVVSRARGVALLGPPPVELFGAVPLEAFRDSVGADLAWTLSDDHLLESPYYGVLNVARTLRADAVGIERAVAEGTSKEEGALWALANLPEPRRGVVAQALACYRSGRPVSEAERPTDGHDWDPAALRAFRDDARDALAGWVSP
>NC_012669.1|WP_050761567.1|505262_506003_-|LPXTG-cell-wall-anchor-domain-containing-protein
MLTSVGSPHPSKRRHSVRALAVTCLLVPAALLAAPALGATAPPTTEPPPSPSPAPTNTDAPTPEPTNYEPPPEPTMLLNVLSPICDGDAPYLVYDVDVENTEGSTATITFVNPSGGNVVYTDLPLSGTILWPGAAVDGSGAPTDWPGWAFVGGEWVEDSSDAWLRNPITVTIEVNPTASATVSYPPATPSCSANPPGREDPPPPSSGEARLPNTGTETLTYAGIAGGLVVLGGLTVAAVRRRAHQG
>NC_012669.1|WP_050761570.1|506169_507993_-|DUF4012-domain-containing-protein
MADVREDDTREQDVLDDLLTDDDAARPARGRRTGRRIVGWSIAALLVAVVAAAALLALDALRARDALAEAVPLVQAAEQQLEADPTADVDLAHLQDLTTTARTSTDGPLWWLAARLPGLGADVHAVSVSADAVDVVTHDVLPPLLAARDGVDLAALRPVDGRVDLAPIQAAAPLVREASDALAGVVADVAALDPAELRGAVAGPVESLQAGLATLDEQLTSARAVTTVLPPLLGADGEQRYLVLFLTNSELRSAGGIPGALAVLTADDGRVALTDQVSTADVGPFDDPVPGLAPEDAEIFGDRPARYIQDTTMLPDFPSAASLAATMWEASGRGAVDGVISVDPVALSYVLTSTGPVDVPGGRIDADGAVDLLLSGAYAMFPEPAQQDEFFAGVSAAVFGSALGGAVDPSLLATAVERAAQEHRINVWSRDADLQADLVGLGVGGSLAAEPAASGVFLNDGTGAKLDYYLDVETTSVAACAADADAVTLTRTVTLTSSVPADVAQLPWYVLGSAGAGSLEPGVLRTNVAIYSPAGGSIDSIARDGVVIGGDVHDDGAGRQVTVVTVELAPGESTTLTVTTSGAAGAGGTWMTPTARHGGDAAVATCG
>NC_012669.1|WP_012725500.1|508358_510959_-|FtsX-like-permease-family-protein
MRRVAWREVREHLGRFGLSVLAVLLGVAFVTGTFSLRAMLSATFSSIVQSTIQGDAYLRGPAVADSDDAGGFDPADGPPEGGSSGAMFGGGGRALVPLTLADDAAAIDGVAQAVPDVSGPLVLVGADGEAVINGQAPSIGVALADDDPGVTIVEGRAPRAADEVALETGALAASGLAVGDATQVVLGDSVREVTVVGEASLGTPAAGATLTFLDLDTATAAYAPEGLVGSVAIYAEDGVALDDLLAALEPLATDDVEVASGDELREEANAQVQSILGFLGTFLLVFAGISLFVGAFIVANAFAMSVRQRQRDFALLRALGASPGQVFGVVLVQAAVVGLVGSAVGAVAGYGLVHVVRAGLRSVFGLTLSGEIPLSAATIAACVVAGTLVSVVAAAIPARRAALTAPVEAMRDDVVVTERSLLLRAIVGTVLLVLGAAGVVAAVRDADAALPGGRGLWLGVGAGAALLGTIAIAPVIARACARVLALPFLPIKPLGALARGNVTRNPRRTASTASALLIGMALVAACAVIAASAQASTRSIVTTEVAADLMVRSATGVVPADAVAAVEGVPGVGTADAVRFGEGRTEGPEGGSETATLGGIDAEGVQRAFTLDVRSGSLDALADGEVAVQQRVAVEQGWAVGDSIELTGDGGARLTTSIGAVIDSQVVAVDVLLADEQFDEIMRQPQVAAVLVDAAPGTSVADLGDALDTALEPFVVVSALDADELTSLLGDMVDQALAILYALLALSVIIAVLGIVNTLALSVVERTREIGLLRAVGLGRLQLGATITIESILIAVFGTFVGVAVGVALAAALPSVYADQGLSVLAVPWDRIGLILALAVVVGLVAAVGPAVRASRLPVLEAISTE

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Crispr_ID: NC_012669_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012669_4

532784-532876

Orphan

Consensus_repeat	Method
TGGGTCAGTGACGTAGGGGCTCGGGGGTGCTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012669_4

>merge|NC_012669|4|532784-532876|CRISPRCasFinder
TGGGTCAGTGACGTAGGGGCTCGGGGGTGCTGCGGTTGTGTACGTCACTGACCCGCCAGCTGGGTCAGTGACGTAGGGGCTCGGGGGTGCTGC

>NC_012669|4|4|532784-532876|CRISPRCasFinder
TGGGTCAGTGACGTAGGGGCTCGGGGGTGCTGC	GGTTGTGTACGTCACTGACCCGCCAGC
TGGGTCAGTGACGTAGGGGCTCGGGGGTGCTGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012669.1\|WP_144016690.1\|538664_539465_-\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_012725512.1\|522926_524591_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173857
NC_012669.1\|WP_012725520.1\|534058_534619_-\|DUF664-domain-containing-protein	unknown	unknown	gnl\|CDD\|368218
NC_012669.1\|WP_043346453.1\|530750_531644_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|225312
NC_012669.1\|WP_012725516.1\|528229_530719_+\|family-43-glycosylhydrolase	unknown	unknown	gnl\|CDD\|350128
NC_012669.1\|WP_144016864.1\|539472_540198_-\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_012725511.1\|522425_522728_+\|DUF1540-domain-containing-protein	unknown	unknown	unknown
NC_012669.1\|WP_012725521.1\|534775_535045_+\|DUF1876-domain-containing-protein	unknown	unknown	gnl\|CDD\|378103
NC_012669.1\|WP_012725523.1\|535732_536848_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|236191
NC_012669.1\|WP_012725513.1\|524597_525563_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_012669.1\|WP_012725525.1\|537669_538638_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_012669.1\|WP_012725509.1\|519539_521267_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_012669.1\|WP_012725524.1\|536869_537673_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912
NC_012669.1\|WP_144016689.1\|535101_535536_-\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_012725510.1\|521238_522210_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225176
NC_012669.1\|WP_012725514.1\|525559_526438_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_012669.1\|WP_012725519.1\|533005_534022_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_012669.1\|WP_144016863.1\|531738_532722_+\|biopolymer-transporter-Tol	unknown	unknown	gnl\|CDD\|223893
NC_012669.1\|WP_012725515.1\|526434_528072_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NC_012669.1\|WP_012725528.1\|540251_541136_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054

Protein	Function_ID	Function_description	E-value
NC_012669.1\|WP_012725512.1\|522926_524591_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173857	cd08492, PBP2_NikA_DppA_OppA_like_15, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	3.37649e-168
NC_012669.1\|WP_012725520.1\|534058_534619_-\|DUF664-domain-containing-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	1.21819e-30
NC_012669.1\|WP_043346453.1\|530750_531644_-\|VOC-family-protein	gnl\|CDD\|225312	COG2514, COG2514, Predicted ring-cleavage extradiol dioxygenase [General function prediction only].	2.66891e-81
NC_012669.1\|WP_012725516.1\|528229_530719_+\|family-43-glycosylhydrolase	gnl\|CDD\|350128	cd18616, GH43_ABN-like, Glycosyl hydrolase family 43 such as arabinan endo-1 5-alpha-L-arabinosidase. This glycosyl hydrolase family 43 (GH43) subgroup includes mostly enzymes with endo-alpha-L-arabinanase (ABN; EC 3.2.1.99) activity. These are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. The GH43 ABN enzymes hydrolyze alpha-1,5-L-arabinofuranoside linkages. These arabinan-degrading enzymes are important in the food industry for efficient production of L-arabinose from agricultural waste; L-arabinose is often used as a bioactive sweetener. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	8.19416e-121
NC_012669.1\|WP_012725525.1\|537669_538638_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	6.76053e-93
NC_012669.1\|WP_012725521.1\|534775_535045_+\|DUF1876-domain-containing-protein	gnl\|CDD\|378103	pfam08962, DUF1876, Domain of unknown function (DUF1876). This domain is found in a set of hypothetical bacterial proteins.	3.30458e-32
NC_012669.1\|WP_012725523.1\|535732_536848_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|236191	PRK08224, ligC, ATP-dependent DNA ligase; Reviewed.	0
NC_012669.1\|WP_012725513.1\|524597_525563_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	9.49342e-100
NC_012669.1\|WP_012725509.1\|519539_521267_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.92719e-58
NC_012669.1\|WP_012725524.1\|536869_537673_-\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	1.04591e-11
NC_012669.1\|WP_012725510.1\|521238_522210_-\|alpha/beta-hydrolase	gnl\|CDD\|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	7.78074e-31
NC_012669.1\|WP_012725514.1\|525559_526438_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.5941e-84
NC_012669.1\|WP_012725519.1\|533005_534022_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.53778e-55
NC_012669.1\|WP_144016863.1\|531738_532722_+\|biopolymer-transporter-Tol	gnl\|CDD\|223893	COG0823, TolB, Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion].	4.94504e-13
NC_012669.1\|WP_012725515.1\|526434_528072_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	0
NC_012669.1\|WP_012725528.1\|540251_541136_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.0816e-51

>NC_012669.1|WP_144016863.1|531738_532722_+|biopolymer-transporter-Tol
MHDVETRERHRAWVSRDVLPEAPNWTPDGAHLVLNGGGRLLVIDAERAVAPESVTPSPVDAAGLPPVNNDHVLAPDGRTVFASAEDGHLYAVPLAGGSARRVSSSRGPTFTHYLHGVSSDGATLSYVGLERRADGVRTNLFTMPAAGGPSVQLTDDDFPDDGAELGPGEDGTEWLWFSSERPLPGAPRRAPGHAQLFRMRPDGTGLEQLTHDERVNWFPHPSPGGTRVAYVSFPPGTLGHPADVADVRIRLLPLSGRAPSGADGELGSIREGMAPESTPVRPPGGVDDDGVGRPRDLARVFGGQGAMNVPSWAPDSRRLAYVDYSPV
>NC_012669.1|WP_043346453.1|530750_531644_-|VOC-family-protein
MTRDLMAADTRMGAVTLHVGDMTAMRTYYTRALGLDVIAENSTGSRVTLGRGAAPIVVLVHAPDLPRPRRGEAGLFHTAILFDDAASLAGALARLAQHAPHTFTGSADHLVSEAFYATDPEGNGVELYVDRPRSAWRWTGSHVVMDTLPLDPNAYLQAHATPSALEDTPGEDDAVVGHVHLQVGDVPTARAFYVDVLGFDETAALGHSALFFSAGGYHHHMAANTWASMGAGPRAQSLRLAQIEIDVPSADDVAALADRLRVAGIAHELDGGGGPGATALLRVADPWRNELHLTSAR
>NC_012669.1|WP_012725516.1|528229_530719_+|family-43-glycosylhydrolase
MSPATPRTRRLAVVGLATASLITTLVAAPAAADPPDPAIDTGDPAAVAAASVTPSPPPEPATITNPVSSPFADSYADPAVLRGRDGWFYAYATSDPLVSGGEFGLMHMARTRDFADWEYLGTVFDDATRPAWAAPGSFFWAPDVRYVNGEYRLYYTVTDSLAKPGADPGIGMATAPTPAGPWTDIGRPVLESQVLAEAGATAFDLRDYDGAVNSPRELRSPELAATESARAAVPAYQGLIDPSVLADTDGSLYLYVGGFAGGPHVTRLDDTGTTAIGELQQIAVSDRYEGSYVVQHDGAYYLMVSAAGCCSSVASGYSVFAGRSDSPFGPFVDAAGVPLNQSRAGGTQVIAANGNRWVGVGHHAVVTDTTGQDWMVYHGIDRNDGWLNEPGGINKRPMLVDRLDWIDGWPVVNAGAGPSDGPEPGPVTGSALGITTDDPASGRAFRALTGSFASVPDDDGDAGQVAALRPGRRVPAVAVARELLRGENRVEADVRLAGADAEACVRVDGLRRGVEVCVDGAARELVVDARPGGRDVTAAVPERIDLEGWHTLVVTLEGDAVAAELQESRLGDPIARAVADVRRGGGVEGLLSLTARGAGADLDNLSVARLAEGPTTRVPDPEVGDVTYTQTFDGSLDDVLADGWTLLGEHPGLTTADGALSWPLTSGDIAGANGAGPVLVRDAPAGDWVLETDLELDLGTDTVRNFQQAGLLVMADENFFVRLSSVAIGHSRTVEFFTEREHQGVLLLGGHLDGPPATEITLRILRTENAAGEQLYRSAFSIDDGVTWRWGMTWTLPAGTDVRIGLQAGGGATPATTAAFEEVRIRDAA
>NC_012669.1|WP_012725515.1|526434_528072_+|ABC-transporter-ATP-binding-protein
MSAADGVVATSSSAPLLRVAGLSVTYRGRRGVHQAVRGVSLDVARGEVVALVGESGSGKTTIGRTILGLLPASAERYGAVELDGADLLRLPDRRRRRVLGARIATIPQDPLAALNPVQRIGPQVAEVLAIHGLASGDAARARALEALRLAGLDDAEARYRQYPHELSGGQRQRVLIAIAIVAGPELIVADEPTSALDVTVQRRILDHLEHLVRETGTSLLLITHDLGVAGDRADRVVVLSDGEVVEQGATGAVLERPEQPYTRALLEATPDRRPPATPPPSAGSSDSPALEVRGLGRTFHVTGRPPVTAADDVSFTIPRGGALGLVGESGSGKTTTARIVLGLLRPDAGEVLVDGRVQDSPAEIRRARRFVQPVFQDPYSSLSPHQSIASSIAEPLRALGGGNRAERRARVAELLDRVHLPASVGRRRPTELSGGQLQRVAIARALAIHPRLVVCDEPVSSLDVSVQARVLDVLAELREQDGLALLFISHDLAVVRAVCEDVAIMRAGRIVEQGRTLDVFASPASPYTAELLAAIPGRRTAAAVA
>NC_012669.1|WP_012725514.1|525559_526438_+|ABC-transporter-permease
MTTSALTVATADPSGRLGTRRLPLGRALREPGLVLAVAYLGLVLLAALAPNVLTTWDPVTDVDPAASLSAPSAEHWFGTDALGRDVYSRVVHGANLSITAGLLAVSISLVVGVLAGVVSGYVGRWADSTIMRVMDVMIAIPGLLLSLAFVSILGFGVVNVAIAVGIAGIPGFARLARAETLRLRNLAYVDAARCSGSGSARIIVRHIVPGAGTAVVVLAALEIGGAVLAVSALSFLGFGAVPPTPEWGSMVNEGRSHIASAWWLTTFPGAAIAATVLACNRISRAVRVAGRS
>NC_012669.1|WP_012725513.1|524597_525563_+|ABC-transporter-permease
MRWYILRRLGQAALVLWGAMTLSFAIVHLVPGDPVRIMLGVGDGAEGGSAATTEQIEQVRSELGLDRPVLVQYVAFLARAVTLDFGTSYSTQRPVTEVIAGATPPTLQLAALSIALSLVLGLVFALAGALLPTRWIRSLFQSVTVLGIAVPSFWVAILLLQVFSFSLGWFPAFGNDSFAALVLPAFTLALLTAGTLAQVLGRGIVESLAQPYADTARAKGASQARVVVRHALRNGSLPVFTIVGMMVGGILSGATIVETIYGRNGLGTVIVDAITARDFPLIQALVIFSGGVFVIVTLLVDLGYRYIDPRVTSPAASEVLV
>NC_012669.1|WP_012725512.1|522926_524591_+|ABC-transporter-substrate-binding-protein
MPRSTTRSVVPSALNRRGFLLGTASVAGAGVLTACAGGGGEPGSSGSTASGEPTTGGTLTVAFPADPENLDPHQRPQLYPRTITRQIADSLTDQDPETGEVIPWLASSWEISDDVRTFTFTLRDDVTFSDGTPLTADVVTANWERILEIGPLAYVAAGLLRDYSSSEVIDSHTVSITFANPNAQFLQATASQSLAVLAPATLALTPEEVAAGDVIGSGPYILESYTPGEDVVLTVREDYAWGSPLYANRGRGYVDRIEFSIIPEPTTMAGAVASGQIDFAYLLDVSVLSTVESSDAELIGTDMPAIAIPIVPLVYRPIFADERTRRALSLATDREAIVDSVFEGRYQPASAVLTKANPGWVDLSDQLAYDVDGAIALLEEAGWTTVGDDGLRSNDAGEPLRFEIQYTSAGTSSELMLQLLQQQWRAVGADFVLTPVSTPSEANLHEYPFDITTWSQTRADADVLRTVYSSFFENQSFLFDNADPELDGLLTELQTTVDAAARLEVSGEAQRLIVERGYSIPLYDLTQFSAASSATSGAHADIEGKPVLVDIWKP
>NC_012669.1|WP_012725511.1|522425_522728_+|DUF1540-domain-containing-protein
MTATLEMPHVAECTVLGCDYNHDGCRAFAVTISSAHAGSTASCATFIDIGARGGLDRVVAQVGACQRTDCVFNESLECRAEAVRIGPGGGTAHCLTYTHG
>NC_012669.1|WP_012725510.1|521238_522210_-|alpha/beta-hydrolase
MSTELDERPDVLGSEWVARTLPLAPDEADPEGELVATLVRKAGPPSSSTAVLYVHGFTDYFFQDHHARAWAGHGIDFYALDLRRYGRSLRAHHAAGDVRDLRAYDEEISAAISVLRAERGHERVILLGHSTGGLILSLYAHAHPRAADALVLNSPWFDLNEAALRRMIATPLAESISRLDPTRRVGKLGGAYGRSLHTSTGGSWEYDLAWKPIEGFPVRAGWLRAIRRAQARVARGLDVRIPVLVCSSTRSGGVAGRPATPEELASTDTVLDVQHMWRGAQGLGDDVTIVAVPGGLHDLTLSAPRARADFERAVFTWLSARLP
>NC_012669.1|WP_012725509.1|519539_521267_+|MFS-transporter
MTATTASTAPTTDTDSDAEHKQILRVLVGLLLALFVAMLSGTIVANALPVIIAELDGTQQQYTWVVTATLLASTAVTPLFGKLADLYDKKKLLLIGIGIFAVGSLLSGLSTSAGMLIGFRVIQGVGLGALQALVQITIATIISPRQRGRYAGYMGAVMAFATVSGPLLGGLIVDVSWLGWRWCYWSAIPLALIAMVVLARRLHVPPPSRTEVKVDWLGATLISAAVTLLLLWVSFAGPTHSYDWISWQTAVMVPGALALFGLFIWVESRVAEPIVPLWILRERTTTLAIVASIAVGVGMFGASVFLGQYFQIARGYSPTEAGLLTIPMMLGLLVSSTVSGRFVTQIGRWKPFVVWGLVTFTAGMGLLGSIQYGTSLWLIGVFMLVAGIGLGASMQNLVLAVQNTVPLSDMGAATSSITFFRSLGGAMGVQVLGAVFASHVSSLTATRLTDAGIPVAPGGDGGGSLDLSELPDAVADIIRSAYGDSIGLLFLIGAGLALVGLVAALFMRGTHLRDTVDLKAAVAEAAEEDVAVETAAATALGAAVAVDETADQTADETADAVDDADGVTAGARSTT
>NC_012669.1|WP_012725519.1|533005_534022_+|Gfo/Idh/MocA-family-oxidoreductase
MTTHLETDRPLRWGILGPGRIAEKVAADFTHVRDGVLVAVGSRSQERATAFASRFADVAPGPIRPHGSYADLLADDGVDAVYIATPHSEHARNAVDTLRAGKATLVEKAFTATYAGAERVVATARETGVFAMEAMWTRFQPAIVRMRELIADGAIGEVRGVQADLGTRREFDPDDRTFNLALGGGTLLDLGVYVVSFAQMVLGDPVGVTARGSLLPSGADAEAGLLLDYGDGRVATLQTSFVTPSPGNARVYGTAGWIDVPPRFHHPHEIVLHRQGRDAVTERAMPDGAGYALELDEVARCVRAGRPESAVMPLADSLAVQRVLQDAADQMGVAFVDS
>NC_012669.1|WP_012725520.1|534058_534619_-|DUF664-domain-containing-protein
MGERPERWTRGTVYTDMWVDPADDPRNTDGVSPDGELATLQDYTASYRFTLTMKCEDLDAEQLARRSVPPSTMSLLGLLRHLAATERDWRNGMGDADPLPQLHGGTDADFDGAVADPAVVDAAYADLAREQAATDAALARHPDLGERLGEEQIAVREIWVHRIEEYARHCGHADLLRECIDGRVGQ
>NC_012669.1|WP_012725521.1|534775_535045_+|DUF1876-domain-containing-protein
MDATKHWSIAVEIDEHDDTTRAQARLETAAGREVRGLGHAQRNPLDASVPEIGDELAVARALRNLADHLLHTTEKDIEGATGEPAHLYR
>NC_012669.1|WP_144016689.1|535101_535536_-|hypothetical-protein
MGRRGMWFTVSAAAVLALAGCSGGGGGNVDRTDPVAVSQAFVDAVAAQDSGAACAQMADEDGPIADGDAQACEDQVDGFISEFTEEELEIFGDVEVADAAVNEGGSTAYVQDESYSADTPEDARMPLILNLVDDEWWVDIDVLN
>NC_012669.1|WP_012725523.1|535732_536848_+|ATP-dependent-DNA-ligase
MALPLTSPIDPMLAKSVRGVPDADAVPGGYAYEPKWDGFRTIVFADDGDVELQSRNGKPMTRYFPEIVDAVKAELPARCVVDGEVVLSRGGRLDFELLGQRIHPAASRVKMLAEHAPAALVVFDLLALGDDDLTQRPFAERAAALDELGLDGPSVHVTPRTRDADVAREWFTTYEGAGLDGVVAKPLDGAYEPGKRAMLKIKHERTADVALAGYRLHKTSTDERPLIGSLLLGLFDDGGDLRFVGVSASFPAARRAELYDELQELRVGEGDEHPWGNWQQPEGSRRPGAVSRWNAGKDLSFTALRVERVLEVGYDHMEGDRFRHTAQFKRWRPDREPTSCTYAQLDEAVGYDLAELLPGAPTAAPGFTGAL
>NC_012669.1|WP_012725524.1|536869_537673_-|ABC-transporter-permease
MTTTTVPAGPRSRRGGMPGLGRLVRTEAKLFVRSPGDVFFALIFPTVLLVAVGFVIPGMRETIVEPGSPYDGLQVIATYAPVALAAAAATASLMSFPVVIATYRAQGVLRRLSTTPMRPQGVLLAQVTIAIVVIAVAAALAIAAGFLAFDLPVIDNPLMLAVGVALSALACLAIGMLVAAIVPTISLANAVASLLYFPLLFLGGMWLPLPLMPDGLARVASFSPLGAGVEVMSAAWIGAPVPGAQVLVLLAYPVVLLPIAAKVFRWS
>NC_012669.1|WP_012725525.1|537669_538638_-|ABC-transporter-ATP-binding-protein
MARHHADDGVPPVVEVRHLRKSYGEKVAVQDVSFAVAPGEIFGILGPNGAGKTTTVEAIAGLRHADSGDVRVLGIDTQAEPDRIRTALGMQLQESALPERITVREAIDLYGSFYPDPMPTEQLIDMLDLRDRAGARYAALSGGQKQRLSIALALVGRPQVAILDELTTGLDPAARRATWDLIETVRDSGVTILLVTHFMDEAERLCDRLVVIDGGRIVAEGSPAELVSGDGELRTIHVRLAEAPSAAVLEALRAAPDVATVTGDGLDLEIRGGRRVLPSAVAALDAAGIVPESLRTGARSLEDVFVGLISHDDTPAQEGAHP
>NC_012669.1|WP_144016690.1|538664_539465_-|hypothetical-protein
MSTKGRAVNTAPSTTSAVDRAAAARRREASMARQVVLGSLRGTLPTYISFWVVMVIVLVVLTIVQARTGALEEPVFAFIGSGRWFLFVMGIIVPVAMLATHVVGGGGTRRSVVRGLWALAIASGIAFGLLALVMTIVQNALWAANDWPDVSLTGRSYVVTQPWRLALSETVCNAVYYVAGAAVGTGYYRWGGWRGTAALPLAAVPAVVAEVTLQGSSYGEPLARALGMAAFSVPVAVAGSILATALAAGLLHLIVRDIRIRALTSS
>NC_012669.1|WP_144016864.1|539472_540198_-|hypothetical-protein
MTRQVALGCLRSTWVVFAGFWVVMVIVLAVLTVVQARTNALDEPVFAFLGSSRFFLFVMGIILPLALLAPHVVGSGGTRRSIVRGHYALALASGVTFGLLAVLLTLAETRIRTMNDWPLVTISSSGLADSSEPWLMWFAESAYNVLYYLVGCTVGTAYYRWGGWRGTAALPLALIPAAVAELALQNEWYGEWYGQSIAAALGIGTPSAPVAVLGSLLAIALAGWLLHVVVRDIPIRGFTPS
>NC_012669.1|WP_012725528.1|540251_541136_-|ABC-transporter-ATP-binding-protein
MTPAPFGAELRDVVVRYGDEQALDGADVAFRPGIITGLIGRNGAGKTTLLSLLASLRRPTSGTVRVDGVDPFEDPLVMAGVHLVRESGDVIGDEPVRRTLRYYAATRPNWSTDLAAELLDVFAIVTKKSPNSLSRGQRSALGAVLGLASRAPLTIFDEVYLSMDAPSRYAFYDAVLADYAEHPRTIIISSHLIEEVERLFEDVVIIDRGRVLVADSADAIRARGTGLTGPADAVEAIAREHTVLARQRLGGVVRVTLDVALDDDARRAVRAAGVEVDSVGLQDLFVHLTRKETP

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Crispr_ID: NC_012669_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012669_5

1723222-1723295

Orphan

Consensus_repeat	Method
GACGATACGACCAGATCGACCACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012669_5

>merge|NC_012669|5|1723222-1723295|CRISPRCasFinder
GACGATACGACCAGATCGACCACGCTCCCGGAGAACACGGTTCTTCCGTCGACGAAACGACCAGATCGACCACG

>NC_012669|5|5|1723222-1723295|CRISPRCasFinder
GACGATACGACCAGATCGACCACG	CTCCCGGAGAACACGGTTCTTCCGTC
GACGAAACGACCAGATCGACCACG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012669.1\|WP_187292874.1\|1726667_1727435_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_012669.1\|WP_015882005.1\|1729799_1730528_+\|glycerophosphoryl-diester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176506
NC_012669.1\|WP_015881994.1\|1715673_1716162_+\|TIR-domain-containing-protein	unknown	unknown	gnl\|CDD\|378100
NC_012669.1\|WP_015881990.1\|1707271_1708366_-\|DUF91-domain-containing-protein	unknown	unknown	gnl\|CDD\|224552
NC_012669.1\|WP_015881996.1\|1717714_1718848_-\|DUF262-domain-containing-protein	unknown	unknown	gnl\|CDD\|377008
NC_012669.1\|WP_144016741.1\|1716155_1717064_+\|HIT-domain-containing-protein	unknown	unknown	gnl\|CDD\|238608
NC_012669.1\|WP_015881997.1\|1719266_1721018_+\|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl\|CDD\|378931
NC_012669.1\|WP_015882001.1\|1725578_1726049_-\|ribose-5-phosphate-isomerase	unknown	unknown	gnl\|CDD\|376799
NC_012669.1\|WP_015881999.1\|1723363_1724728_-\|sn-glycerol-1-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|341454
NC_012669.1\|WP_083770152.1\|1710857_1711913_+\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341137
NC_012669.1\|WP_015882006.1\|1730543_1732118_+\|xylulose-kinase	unknown	unknown	gnl\|CDD\|198360
NC_012669.1\|WP_015881993.1\|1712054_1715210_+\|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223683
NC_012669.1\|WP_015882004.1\|1728387_1729743_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270451
NC_012669.1\|WP_043349004.1\|1724724_1725543_-\|HAD-IIA-family-hydrolase	unknown	unknown	gnl\|CDD\|319833
NC_012669.1\|WP_083769985.1\|1721093_1722824_-\|alkaline-phosphatase-D-family-protein	unknown	unknown	gnl\|CDD\|226070
NC_012669.1\|WP_015881989.1\|1706412_1707141_+\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_015882007.1\|1732099_1732942_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_012669.1\|WP_015882008.1\|1732989_1733892_-\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|188630
NC_012669.1\|WP_043349007.1\|1727515_1728343_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223472
NC_012669.1\|WP_015881991.1\|1708647_1710633_+\|SAM-dependent-DNA-methyltransferase	unknown	unknown	gnl\|CDD\|223363

Protein	Function_ID	Function_description	E-value
NC_012669.1\|WP_187292874.1\|1726667_1727435_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.32352e-83
NC_012669.1\|WP_015882005.1\|1729799_1730528_+\|glycerophosphoryl-diester-phosphodiesterase	gnl\|CDD\|176506	cd08563, GDPD_TtGDE_like, Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase (TtGDE, EC 3.1.4.46) and its uncharacterized homologs. Members in this family show high sequence similarity to Escherichia coli GP-GDE, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. Despite the fact that most of GDPD family members exist as the monomer, TtGDE can function as a dimeric unit. Its catalytic mechanism is based on the general base-acid catalysis, which is similar to that of phosphoinositide-specific phospholipases C (PI-PLCs, EC 3.1.4.11). A divalent metal cation is required for the enzyme activity of TtGDE.	3.54118e-50
NC_012669.1\|WP_015881994.1\|1715673_1716162_+\|TIR-domain-containing-protein	gnl\|CDD\|378100	pfam08937, DUF1863, MTH538 TIR-like domain (DUF1863). This domain adopts the flavodoxin fold, that is, five parallel beta-strands and four helical segments. The structure is a three-layer sandwich with alpha-1 and alpha-4 on one side of the beta-sheet, and alpha-2 and alpha-3 on the other side. Probable role in signal transduction as a phosphorylation-independent conformational switch protein. This domain is similar to the TIR domain.	8.0488e-29
NC_012669.1\|WP_015881991.1\|1708647_1710633_+\|SAM-dependent-DNA-methyltransferase	gnl\|CDD\|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	2.49106e-66
NC_012669.1\|WP_015881990.1\|1707271_1708366_-\|DUF91-domain-containing-protein	gnl\|CDD\|224552	COG1637, COG1637, Predicted nuclease of the RecB family [DNA replication, recombination, and repair].	1.55766e-08
NC_012669.1\|WP_015881996.1\|1717714_1718848_-\|DUF262-domain-containing-protein	gnl\|CDD\|377008	pfam03235, DUF262, Protein of unknown function DUF262.	3.10566e-30
NC_012669.1\|WP_144016741.1\|1716155_1717064_+\|HIT-domain-containing-protein	gnl\|CDD\|238608	cd01277, HINT_subgroup, HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. Although the biochemical function has not been characterised for many of the members of this subgroup, the proteins from Yeast have been shown to be involved in secretion, peroxisome formation and gene expression.	1.36149e-37
NC_012669.1\|WP_015881999.1\|1723363_1724728_-\|sn-glycerol-1-phosphate-dehydrogenase	gnl\|CDD\|341454	cd08175, G1PDH, Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner. Glycerol-1-phosphate dehydrogenase (G1PDH) plays a role in the synthesis of phosphoglycerolipids in Gram-positive bacterial species. It catalyzes the reversibly reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in a NADH-dependent manner. Its activity requires a Ni++ ion. In Bacillus subtilis, it has been described as AraM gene in L-arabinose (ara) operon. AraM protein forms homodimer.	1.73229e-126
NC_012669.1\|WP_015882001.1\|1725578_1726049_-\|ribose-5-phosphate-isomerase	gnl\|CDD\|376799	pfam02502, LacAB_rpiB, Ribose/Galactose Isomerase. This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).	2.56288e-53
NC_012669.1\|WP_043349004.1\|1724724_1725543_-\|HAD-IIA-family-hydrolase	gnl\|CDD\|319833	cd07531, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Bacillus AraL phosphatase, a putative sugar phosphatase. Bacillus subtilis AraL is a phosphatase displaying activity towards different sugar phosphate substrates; it is encoded by the arabinose metabolic operon araABDLMNPQ-abfA and may play a role in the dephosphorylation of substrates related to l-arabinose metabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.77782e-73
NC_012669.1\|WP_083770152.1\|1710857_1711913_+\|restriction-endonuclease-subunit-S	gnl\|CDD\|341137	cd17248, RMtype1_S_AmiI-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Actinosynnema mirum DSM 43827 S subunit (S. AmiI) TRD2-CR2. The S. AmiI S subunit recognizes 5'... CAGNNNNNNNTCGA ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, S. AmiI -TRD1 recognizes CAG/CTG, and TRD2 recognizes TCGA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	1.17499e-109
NC_012669.1\|WP_015882006.1\|1730543_1732118_+\|xylulose-kinase	gnl\|CDD\|198360	cd07783, FGGY_CarbK-RPE_like, Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases. This subgroup is composed of uncharacterized proteins with similarity to carbohydrate kinases. Some members are carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins. Carbohydrate kinases catalyze the ATP-dependent phosphorylation of their carbohydrate substrate to produce phosphorylated sugar and ADP. The presence of Mg2+ is required for catalytic activity. This subgroup shows high homology to characterized ribulokinases and belongs to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.	0
NC_012669.1\|WP_015881993.1\|1712054_1715210_+\|type-I-restriction-endonuclease-subunit-R	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	3.79738e-78
NC_012669.1\|WP_015882004.1\|1728387_1729743_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.17282e-96
NC_012669.1\|WP_083769985.1\|1721093_1722824_-\|alkaline-phosphatase-D-family-protein	gnl\|CDD\|226070	COG3540, PhoD, Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism].	1.11499e-58
NC_012669.1\|WP_015882007.1\|1732099_1732942_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.10344e-56
NC_012669.1\|WP_015882008.1\|1732989_1733892_-\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	6.47551e-61
NC_012669.1\|WP_043349007.1\|1727515_1728343_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	9.80299e-86
NC_012669.1\|WP_015881997.1\|1719266_1721018_+\|right-handed-parallel-beta-helix-repeat-containing-protein	gnl\|CDD\|378931	pfam12708, Pectate_lyase_3, Pectate lyase superfamily protein. This family of proteins possesses a beta helical structure like Pectate lyase. This family is most closely related to glycosyl hydrolase family 28.	2.44643e-06

>NC_012669.1|WP_083769985.1|1721093_1722824_-|alkaline-phosphatase-D-family-protein
MSQAVPSPAVLRRDVAPARSSMTPTSQGSSPMSVSRRSFLAAAGAAAGAAVTDFAAAAPAAAVTFASNPFQLGSASGDPTEDSVILWTRLAPEPTATDFGMAGAPSSISVHWRVATTHEGATSDATSLYDGDVTVTATDCWSAHVDVKTAPGGGPLQAGTTYYFRFAVDGFETWVGTTRTRPAPDADVIASFAVISCQSYATELTGTSYWPGYTHLEQNPMDFVLHLGDYIYESSHANTIPAEIPGDPTTDACRSITDYRRRWGAYLERDNIQRVRRTQPMFYVPDDHEFINDVHGGEVADRTQGVIDRWNNALRALWENMPTRSARPVVEPGTTRLVAEVERTDIRWGRHLDLIVPDMRQYRTRFDHATPTLFGVAQRNRVLNRIATASATWTALGVVSPITSYRISATDPRVAGTWNTYAERGLVTDAIAARRASDPDFSPVFLAGDVHCGYASRVARDQDVPEQDHVATEFSVPSMSSYGTASGGTGRTSWPDRRAGNPTLLSYIGIPASPNEDDGSGYAKCQPYKGYLRCAAGPDYFYTNYITATNVWQSTSVATSRKKLRVTRGAIGALPY
>NC_012669.1|WP_015881997.1|1719266_1721018_+|right-handed-parallel-beta-helix-repeat-containing-protein
MTTSMTRRTVLRGGVAVGLAAGAAAATAGTAGADAGRASGHGRPRAFPVARYGARPDDGRDDTHAIQRAIDAATAHRGPSVVAFERGTYTLTATEFEVLKVTGASNLTIRGATDRRGRPATTLEVNLPLQNKPPNGVHLSLLSCTDTTVESLVLDYNPRFGTSGVIVSVDTANDAVEVDVFDGLPHFDGMRCYSANSWDIATGRMHHVPALTIGTGESTFTNTWTAVPGGEGRRYRIAGFGFTPYVSVGDGMNWHFGIDGPKNLQIIDCVDTRVENVDFPNAIGMCCLAGYNTNLTLRHIRIAPTNGALAVGPRDGFHLSNSRGTLVVDDFDAKGVRWDPLVLRSTLGEITAVDGARRVSVLYPAGAVPMPYEPGDVVTFWSGDEPAERTVASVDRDDAGTTVTLDLDGDVPARAVVGSTLTCSAHEWTTATIRNSTFTDNFGTPLVIMNPHVTIEDCTFVDNAYQVIGLGTTSSGSGPFARDITIRDNTFRSSGWIKKYPKHLASGAITTLCNNGRFDLEAYNSDITITDNVFEDMAEEPFQAAVEVRHARRVHIAGNTYRNVSQRVVVDPATTGEITNEDG
>NC_012669.1|WP_015881996.1|1717714_1718848_-|DUF262-domain-containing-protein
MTSDADDSPESGERSADLLDRTLSDFELEDLVDGDEAPPAVTYSTQDYPVDGLVKRLERGSMRVPQFGVDDPANATAGFQRGFVWTKGQMDRFIESLLLGYPVPGIFLVKQTDNVMLVLDGQQRLETLRRFYAGTHNARPFALENVSADFRGRTYKTLGEASKLALDDSFMQATIVSTDGSTEVNDAIYRIFERLNSGGTQLTPHEIRVALFAGPLMVLVEELNSFPAWRALFGPPNKRIRDHELVMRIAALYLHAPEYARPLKSFLNNFSAAYRNARELPNDAADLFRRATVILERDAGRGALRRGEVGQVNAAQAEAIIVGLMRKLAQGREPAAVASAISALKGSDEFARVTTRSTADNDAVRDRLSLAAAAFAS
>NC_012669.1|WP_144016741.1|1716155_1717064_+|HIT-domain-containing-protein
MVSEECEFCEIVDRDDPDVREIYRDESVVAFFPTEPAALGHVLIVPRRHVPDIWSLEPDEAADLSRAALLLADAIREAVTPEGLSVIQSNGDTATQTVPHLHIHLVPRWKDDAIGPIWPVGTDFSEVSKEAAMLDVRDAAERLRSFTELPIAPEDRRKHLDYIQAVVTRQSAASSSAKGWLLPIVTATFGFAITQHTWPLAALGMVAVVLFAYLDANYLRSEKRFRRLYDTVARSTRRVPLFTLDPVDADEILANDAPAMSKWKKAVHTYLPKWSIWASWSIAPFYIALLLLGVGVLIASAS
>NC_012669.1|WP_015881994.1|1715673_1716162_+|TIR-domain-containing-protein
MATKTVFYSFHYERDVNRVQLVRNINALEGQPLLNAQGWEAVRRRGQQAVVDWIDDQMRYKRAVVVLIGQDTAGRPWVIYEIEKAWEDKKPLVGVRIHGLSSFGSADRAGPNPFDAASGVSGIPVFDPTVTGWRGDIDTKATYSNLVDNLEYWVAQAKARAW
>NC_012669.1|WP_015881993.1|1712054_1715210_+|type-I-restriction-endonuclease-subunit-R
MSDSSAELALEVEIAEYLAAHGWLYSPSGQGYDAGLALFPDDVFAWLEATQPAELAKVVTAGSASEAKQRQQLVAALSKRLDAPMSHGGGTLNVLRRPFAHVNAHLNMCQFRPATTLNPKTTADYAAVRLRVVRQVYFSPVKGDNRAIDLVFFVNGIPVATAELKTFFKQHVTSAIDQYKHDRNPAGQPLLGHGNRALVHFAVDDDEVWMTTRLAGPRTYFLPFNRGTLDGGAGNPPNPAGPASSYLWERVLQRDAWLNILGVLMFVRHEEHVDPISGKKSRSSTILFPRFHQWEVVTRLVDAARTEGPGGRYLVQHSAGSGKTNSIAWTAHRLARLHNDANEKVFDTVLVITDRTVLDNQLQAAVRQIDDRKDLVVTIDDTEVRRAGGSKSKALAQALTDKRLIVVVTIQTFPFVMEQLAENAALRENRFAIIVDEAHTSQTGATASEVRKVLSAGGVEVPEGEEIDAEDLLNSAVEQQIADAVTQRATPSNLSYLAFTATPKAKTLELFGRPDPDDPDGLPRAFHLYSMRQAIEEGFILDVLRGYQTYSTAYEIERTAVEHGVDASAGFTDGDGDLVDEKAASRAIMEYVRLHPSNIGQKVRIVVEHFRANVAYLLDGHAKAMVVTSSRKAAVRYKLEIDAYLRTQGYADMQALVAFSGSLDDEEYLIENASEATMNPGLASLDLAEEFKAPRYRVMIVADKFQTGFDQPLLCAMYVDKRLDGIAAVQTLSRLNRTYRAPSGEVKATTFVLDFVNDPLEVQASFEPYFTEARIETRTDPNLVHEVAAKLAEADIYTADDVETFTHAWFTRAGHGALSAAIKGPKDTFATLYASAKTRQDTAELERLELFRKDAGTFVRLYDFMSQVIDYGSTELEKLSVFLRHLVRVIAVDRLSSDVDLSDVVLKRVKQIDRGRLDLGLTGDAVLSPATGAGSGAASRDPKLIALNEIIQRINTLFAGEFEPGTVEGFVRSAATEVSKDPQVVAEIEANEIDQFRKSPTVPHKVIDAVLDVPGLMEKMTGEAIGNPAIIAAIAEAAYLLHQIQRARVLE
>NC_012669.1|WP_083770152.1|1710857_1711913_+|restriction-endonuclease-subunit-S
MPDPLGRACVVPEGLGKTITVVDVAVLRPDPDQADAGYLTYAINSAKTRSEVERQQDGATRQRIPRKRLGRVSIPLPPLEEQRRIADFLDAETTQIDALIAEQERLIGLLKERRASGILQAVTRGLRDVDLKPSTLTWVDAVPLHWTVANIRRFAAMKTGHTPSRSNPEYWVDTHIPWFTLADVWQVRDGRRTHLGETENTISDLGLANSAAELLPAGTVVLSRTASVGFSGVMPRPMATSQDFWNWVCGPELVPEYLMYLFRAMRGEFNALMIGSTHKTIYQPVAAAIRVPVPPLEEQHEIVARIDERTRKTDALINEAEHNIALSKERRAALITAAVTGQIDVTTGGSA
>NC_012669.1|WP_015881991.1|1708647_1710633_+|SAM-dependent-DNA-methyltransferase
MSQLSSFVWSIADLLRGPFKPHQYGTVVLPFTILRRLEGVMAPHREAMVTAVAKADDATMRRALVRRATGLPFYTTSSYTLATALEDPDNLAANLVDYVNGFSAEVDVFKHFDFEARIHQLDAADRLIPVTQGFARVDLSTDHVSNAGMGDLFEHLIFKDFEASNAEAGDFYTPRDAIRLLVDLVFAEDTSALAAPGITRSVYDPAAGTGGMLSVAEEHLHELNPKANLALFAQEINPASYAIAKSDMLIKGQNIENVRLGDTLAEDLFDGETFDFALSNPPYGVDWKAAEKAVRAEHVRGTGGRFAPGLPSVGDGSMLFLLHLVAKMRPVDARGNGGRGGIVLNGSPLFNGGAGSGPSEIRGHLLEHDLVDAIVALPNDMFYNTGIATYLWILDNSKQPERRRKVQLIDATKLGTKMRKSLGSKRVEISTADRGRIVQAYDRFDGVAADGDASGPRSKVFDTLDFAYWSVTVERPLRLNFQVTPERLENVMASKPLSKVEGLVGVLSAFGDELYLNRDEFMGRLGTHLGAHRVGLTTPQRKALWQALGERDETADTCTDSKGRPEPDTGLRDTEIVPFGWSDHPKADDAERDTIQAYFDAEVAPHVPDAWIDWTKTRVGYEIPFTRHFYEYVPPRPLAEIDADLEASVSRILDLLREVEA
>NC_012669.1|WP_015881990.1|1707271_1708366_-|DUF91-domain-containing-protein
MPVEMGLWRIDGARPRRLTAGVLPTEQTLESYLATDPSLLGEPLLVIGRQVPTAYGKYIDLLAIDGDGNLHVLELKRDRTPREVVAQILDYASWVAGLDRDQVIDLANRHLDEPFETAFDSLFDSSPPDELNAELTLTIVATNLDPSSERIVTYLRGFGVPINAVFFSYLEDDERRYLARSWLVAGDEPTSRPAGKRSGKRADWNGRDWFVSFGDGLGRSWEDGERYGFVSAGGDAWYSRTLRSLPVGARVFVHIPKAGYVAVGETLATATRFDEAQVRLDDGWQPLAALPLHATYRHAAEGAPVTDDNSEFVVPVHWLRSSPRSGAYWEKGMFANQNSACKLRQEFTLERLARHFDLDDAAAE
>NC_012669.1|WP_015881989.1|1706412_1707141_+|hypothetical-protein
METQRPSFIQFSLNGHDYQLASRDLESRLVDVAPEVIRKHAVKVNDVWFPVVQAFQVATGIPRSAFRSNTARRHLAALGFEIVGNAEPRSSRDLEAPRVSASEGHTEANVQASLVTALAAKRWRILSVANTATKEPGIDVIASRDGQTVGVEVKGFPSRNYADPARAEERKRTSPSTQAGHWYSQAVLAAMRRRGREPSWRSAIALPDFPRFRDLHGETAGSLAAAQIEVWWVDQEGAVRGP
>NC_012669.1|WP_015881999.1|1723363_1724728_-|sn-glycerol-1-phosphate-dehydrogenase
MTVLATALAGASDTRALEAGVGVLSRTGAVFTETFGDSSAQLVADGTTWAVAGEEVSASLRAAGVSLAPPLVLPATPTVYASYENVSLIREHLRGSDAVPVVVGSGTLNDLVKLASGELGREYLVVGTAASMDGYAAYGASITKDGFKITQYCPAPAAVVADVSVMADAPQRLTATGLGDLIEKVPAGADWMIADALGVEPIDRGVWDLVQGPLRASLADPAGLAAGDLAAVGRLAEGLLMSGLAMQAHQSSRPASGAGHQFSHLWEMEGLGRDAEPPLSHGMKVGLGTIAMCALYEVVLRRDLGALDVDAAVAAWPTWEQMASRIRGAGLPPEVEVAALAQSEAKYVPASALRSRLTDMVSLWPTLAPLLRAQLLPAADIESRLATVGAVTHPAQIGLDLDRFRTTYWRALTIRSRYTLLDLLLEAGLLSSCVDELFAPGGFWGQRPWPGVAG
>NC_012669.1|WP_043349004.1|1724724_1725543_-|HAD-IIA-family-hydrolase
MRPRADELYDAYLFDLDGTIYLGDQLLPGAADLLAELRRRSLPVRFVSNNPTRSPEAYVTKLRGLGLEAELEEVTNTVVAMVRWLEREHPDAVVFPIAERPLVDALLAAGFEVSDDASRVDVVIASYDRTLTYAKLQVAFDALWMHQRAILVTTNPDPYCPLPGGRGEPDAAAVVAAIEASTGVTLTKNVGKPDAAMVHAALAGLDVSLSRCVMVGDRLPTDIRMATDVGMASAMVLTGDSTRAEAEALPAELQPDLLLERVDHLLPGAVTR
>NC_012669.1|WP_015882001.1|1725578_1726049_-|ribose-5-phosphate-isomerase
MAWRVVVGSDGAGFDYKEALKQDLFVSDLVSDVVDVGVPAADDGANYPSVAFEAARRVAAGEADRALLVCGTGLGVAISANKVKGVRAVTAHDVYSVRRSVLSNDAQVLCLGQRVIGLELARALTEEWLTLTFDPTSASAPKVAEIDTYEAGTGAC
>NC_012669.1|WP_187292874.1|1726667_1727435_+|sugar-ABC-transporter-permease
MTSWNMISGTPQWVGFANYVDLLTSPNFHRVLLNTAVFTGAVVIGSVVLGLLLALLFNQKLHLRGVVRTAAFSPYVISGAAVATLWLFLFDPNYGLSRLLFSLVGADSPRWVTDAQWAMPALIIAYLWKGMGFVAIIYLAGLQGLPEEYDEAARIDGAGRWAIFRRITLPLLSPVTFFVMVITIIGTFQAYDLIAVMTGGGPGIATTTLSWFIYERAFKASDAGGAAAAAMILFVILLAVTALQNAYSQRKVHYQ
>NC_012669.1|WP_043349007.1|1727515_1728343_+|ABC-transporter-permease-subunit
MTDSRLRRVLLYAALVVAGLTFLVPVYWLFSSAVKENSDIYQYPPQWLPWPPVIENFGDAWAAAPFNHFLVNSLIVTVVGASIKLVNASLTAYAFVYLRFPAKNLVFLLMLGSLMVPGNVTLIVNYITMANLGWINTYLGLILPSAGSVFGMFLLRQYMLTLPSDITEAAAVDGAGHMRKLFQIVLPMCKPMLVTVGVIAVVDMWNDFIWPLIVTNTVEMRTLPIGLLYLRSAEGYNDWGAIMAGTVIVALPMLVLFLFTQRHIARGLTAGAVKG
>NC_012669.1|WP_015882004.1|1728387_1729743_+|ABC-transporter-substrate-binding-protein
MTRSPFGSPSRRTFLGLGAAGLSAPLLASCAGGGSSGELGSVDLNVPSAFSGREVNIAVWSSMSGNNGEVLQGLVTQFNESQEDIYAELQFQGAYEEAGPKVTAALQAKAVPDVMMFADTWWARFMLNDVLEPLDDYFTDDFNGDAYLPSLFQEGVVDGSTYWLSYGRSTPLFYYNKDQFAQAGLPDRGPETWSELLEWAPALNAIQVSGKALATHAFSSGDDWPFMALIWAFGGRISDGLDVQIDGDAAVEAGTWAQDFVFEHGYGYLAQAPTTDFGAGVVATTVGSTASLRGIYEESDFEVGASFLPQEVTTGVPTGGNGFSMFSGVPDERKQAGFELLTFLGRPDNAAAWTLGTGYLPIVTASQEEPELAQVLADDPNFSVAADQLELAQPTDAVRIFVTDSTSTIIGGIQEVLSDRSKDVATTFGGVAGQLRQGAEDIQDSYDRWYG
>NC_012669.1|WP_015882005.1|1729799_1730528_+|glycerophosphoryl-diester-phosphodiesterase
MPVIAVGHRGAAALAPENTLASFARAEEIGVNQLELDLQTSSDGHVVVIHDASVDRTTNGTGAVADLTFEQLRVLDAGDGATIPTFAEVLDATSVSLQVEIKATTAIEPAVELLRQRPEDARRCEPTSFDAATVGRLAELLPDACVGLIRKVAGPDVLDEAASLGARRVLVGLESADEAFVRAARERGFRVDLWPIRTADDVRRVVELGADGFTLDDPRLVADAGFRMTPDGLVGVDVPARS
>NC_012669.1|WP_015882006.1|1730543_1732118_+|xylulose-kinase
MGGSGGPYVLGLDFGTESCRAAVFDVAGRAVGIAAVPYPTGYPQPGWAEQDPQHWWEAACTAVRRALAESGLSGSEIAGLACDATSLTLVATDAAGTPLRPAILWMDVRAVEQAARADASRSTARRYNGGGTMPASAEWYPFKAAWLKEHEPDVYSRAAHLVDAADWITFRLTGEWTVNLNSAALRMYYDGDNGGWPEDLYDDVGVGDVLGKLTGPVLAPGAPVGELTDDAAAALGLPAGVPVAQGVIDAWAGQIGLGVLAPGRMALITGSSHVFTGQSAEPISGPGFFGAYTDGVVPGEYTVEGGQASTGSVLKWFVEHFAPDVRSASARNGTSPYDVLNERARHLPPGAEGVVVNEYFQGNRTPYTDGDARGMIWGLSLHHGPEHVYRAIQEGVCYGTEHIRRVMADAGHEVHAIVAGGGATRSRDWMQMHADVTGVPITLTHVPDATALGTCVLAAAGAGLFGSVRDAAAAMVRTADVLEPDPDRHEEYGFFVDRYVEAYPLLREPIHAVAARVADQASSA
>NC_012669.1|WP_015882007.1|1732099_1732942_-|DeoR/GlpR-transcriptional-regulator
MSSSHAGRRPSARDRARQERQELIASYVLAKGVATPHELTEVSGASIMTVHRDLDELARRGLIRKFHGGVSAKASSVFESSSAFRLHYQSEHKDALAEAVLERIEPGMSVMLDTSSTNVFLARRIARLDDVPLTVITNYQPILHTLRSCDGVSLIMIGGRYSTVHDAFFGIDAVAMTQGLRANLAVLSTSAMTPDETYHQDQDIVLMKRAMMAAADERVLLMDPTKIRRTALHRLAPTRDFDELLLTDPDDPEFVAAVSEHVPTRIVKAARASEDQALEA
>NC_012669.1|WP_015882008.1|1732989_1733892_-|dihydrodipicolinate-synthase-family-protein
MSSNHAGPTGVICPIVTPLTDDERLDREVLAAHVRAVLPHVDGLMALGTTGELPVLDDAVADELVDVVLSEVGDAGGQIVLGVGGAGWARTRRNLRRVADGVTHVAVCAPFYYATTPAGLLDYFRRAADAAAVPVVLYNIPQNTHVPLTVDLVATLAEHENVVGIKDSGPSREYFTELLALRSPSFTVLRGTDDAAVLEYRAAGADGFVSGLENIEPGLLRAALEAGDDDARAAAVARIGEIAALADGATGLSAIKAAVAILRGGSPRAARPVPTLEADALRDLAARLEVLGLRPHVAVG

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Crispr_ID: NC_012669_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012669_6

1738995-1739082

Orphan

Consensus_repeat	Method
CGCGGGGCTACGTCACTGACCCGCGTGGTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012669_6

>merge|NC_012669|6|1738995-1739082|CRISPRCasFinder
CGCGGGGCTACGTCACTGACCCGCGTGGTGGGTCAGTGACGTACCGCCGGTCCGTGTCGCGGGGCTACGTCACTGATCCGCGTGGTGG

>NC_012669|6|6|1738995-1739082|CRISPRCasFinder
CGCGGGGCTACGTCACTGACCCGCGTGGTGG	GTCAGTGACGTACCGCCGGTCCGTGT
CGCGGGGCTACGTCACTGATCCGCGTGGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012669.1\|WP_015882021.1\|1747077_1750608_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_012669.1\|WP_015882011.1\|1736355_1737264_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012669.1\|WP_015882004.1\|1728387_1729743_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270451
NC_012669.1\|WP_015882009.1\|1733888_1735019_-\|exo-alpha-sialidase	unknown	unknown	gnl\|CDD\|271234
NC_012669.1\|WP_015882010.1\|1735015_1736350_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NC_012669.1\|WP_144016905.1\|1737260_1738085_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NC_012669.1\|WP_015882017.1\|1741471_1743808_+\|alpha-N-arabinofuranosidase	unknown	unknown	gnl\|CDD\|226064
NC_012669.1\|WP_015882008.1\|1732989_1733892_-\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|188630
NC_012669.1\|WP_015882007.1\|1732099_1732942_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_012669.1\|WP_015882005.1\|1729799_1730528_+\|glycerophosphoryl-diester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176506
NC_012669.1\|WP_187292875.1\|1738243_1738915_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_012669.1\|WP_015882022.1\|1750761_1752132_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|293742
NC_012669.1\|WP_015882018.1\|1743858_1745124_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270451
NC_012669.1\|WP_015882015.1\|1739747_1740290_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_012669.1\|WP_015882020.1\|1746085_1746982_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012669.1\|WP_015882019.1\|1745120_1746086_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_012669.1\|WP_015882016.1\|1740328_1741345_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_012669.1\|WP_015882006.1\|1730543_1732118_+\|xylulose-kinase	unknown	unknown	gnl\|CDD\|198360
NC_012669.1\|WP_015882023.1\|1752128_1753526_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270451
NC_012669.1\|WP_015882014.1\|1739142_1739679_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_012669.1\|WP_015882021.1\|1747077_1750608_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.14032e-93
NC_012669.1\|WP_015882011.1\|1736355_1737264_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.82794e-78
NC_012669.1\|WP_015882004.1\|1728387_1729743_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.17282e-96
NC_012669.1\|WP_015882009.1\|1733888_1735019_-\|exo-alpha-sialidase	gnl\|CDD\|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	2.24677e-09
NC_012669.1\|WP_015882010.1\|1735015_1736350_-\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.20136e-14
NC_012669.1\|WP_144016905.1\|1737260_1738085_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	7.98457e-74
NC_012669.1\|WP_015882017.1\|1741471_1743808_+\|alpha-N-arabinofuranosidase	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	1.87137e-62
NC_012669.1\|WP_015882008.1\|1732989_1733892_-\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	6.47551e-61
NC_012669.1\|WP_015882007.1\|1732099_1732942_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.10344e-56
NC_012669.1\|WP_015882005.1\|1729799_1730528_+\|glycerophosphoryl-diester-phosphodiesterase	gnl\|CDD\|176506	cd08563, GDPD_TtGDE_like, Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase (TtGDE, EC 3.1.4.46) and its uncharacterized homologs. Members in this family show high sequence similarity to Escherichia coli GP-GDE, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. Despite the fact that most of GDPD family members exist as the monomer, TtGDE can function as a dimeric unit. Its catalytic mechanism is based on the general base-acid catalysis, which is similar to that of phosphoinositide-specific phospholipases C (PI-PLCs, EC 3.1.4.11). A divalent metal cation is required for the enzyme activity of TtGDE.	3.54118e-50
NC_012669.1\|WP_187292875.1\|1738243_1738915_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	3.48969e-37
NC_012669.1\|WP_015882022.1\|1750761_1752132_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|293742	cd16018, Enpp, Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin. Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.	1.59565e-65
NC_012669.1\|WP_015882015.1\|1739747_1740290_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.09918e-15
NC_012669.1\|WP_015882020.1\|1746085_1746982_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.62804e-84
NC_012669.1\|WP_015882019.1\|1745120_1746086_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.88412e-91
NC_012669.1\|WP_015882016.1\|1740328_1741345_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.08865e-86
NC_012669.1\|WP_015882006.1\|1730543_1732118_+\|xylulose-kinase	gnl\|CDD\|198360	cd07783, FGGY_CarbK-RPE_like, Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases. This subgroup is composed of uncharacterized proteins with similarity to carbohydrate kinases. Some members are carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins. Carbohydrate kinases catalyze the ATP-dependent phosphorylation of their carbohydrate substrate to produce phosphorylated sugar and ADP. The presence of Mg2+ is required for catalytic activity. This subgroup shows high homology to characterized ribulokinases and belongs to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.	0
NC_012669.1\|WP_015882023.1\|1752128_1753526_-\|extracellular-solute-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.7284e-67
NC_012669.1\|WP_015882018.1\|1743858_1745124_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.69858e-93

>NC_012669.1|WP_187292875.1|1738243_1738915_-|GntR-family-transcriptional-regulator
MDVTPLQQEALGDRVARALRRKIVSGELERGTHLVEGPLSESFGVSRGPIRDALRALESDGLVESRRRGAFVVGLDENDIDELYSLREVLEAFALDLVLEQERLDRTPFVDAVEAMRDAAQRGDSASFAEADVMFHRLFYTASHHRRLHAMWHTLEPTFVALLEISTAQDDDLGPSAESHAQILDAVLAGDGDSARTELGAHLLGARSRITAAHQRRTGRPAT
>NC_012669.1|WP_144016905.1|1737260_1738085_-|ABC-transporter-permease-subunit
MLVALAAFTLYPLVETARLSFTDSNGVQASYVGLDNYTYIFSDDLFWSALSNTVYMGALTIVIGIPLSLVIATLINSLPATQSLFKAVYFAPNITSAIAAAIAFTYVFYPTEQGWVNALLGQLGLGPFGFFSDPGTARASVVLMSVWQGLGYTTLIWLAGLQGVPRELHEAAEVDGAGSLRRWWSVTLPMLRPITFFIIVVESINAFKRFADVYQIGGTDGQPGGVLTTIMLYIYRTGFNTFDFGKASAATVVLFLIILALTCVNFALFRRRLS
>NC_012669.1|WP_015882011.1|1736355_1737264_-|carbohydrate-ABC-transporter-permease
MTVQQLTGAPPQQTTAPRPQRSATRARRLGWWLSALVLTIGALAVLLPFVFMISTSFNGQARLSVPFPPQIIPEDFSTEAYRIATLGIDVWRLYGNTLLVAVVEIVLSLGSALLAGYALSKIRPRGSKVILVVALATMMIPLEATIIPNFMTFRWLGMLDTYWALWLPAIAYPFGAFLVKQYLDSVPDELREAARLDGAGELRILMRIYAPLAKGIIATLVILLFLATWNSYLWPLIVINDPTMYTIQLGLASFNQTIGSETYALPDVNLAATVLSLIPILAIYLFFQRYIVASVASAAVKG
>NC_012669.1|WP_015882010.1|1735015_1736350_-|extracellular-solute-binding-protein
MRSRQLSRRAFLSTSAAATALGGAALLSGCGATAGGGSRVGLTTFAANVGIDPRTGREIRGLNDFLSDAGLDGVVAVDVPGRDANSTNSKVQTMLLGGSVDIIQMSTVYPFFRQGLLADLTPYYERDSWADNYIEAIFAPPLERIMYPPWDPAPSTYISSPGILNTLSLAYDAQLFEDFGVEPPGTIPDIDDVVAKLPRLTGTNPRTGEQCYGMYYDPRAASHIMLYYFGRGIDLGTVDPDDPARLAFDTDQVRSGIEQMIATAEFAPPGFEIGQGAENWGTENNTVAINMSVAPAAMQTAQDNGLVDRFVVTEGVRNTEGHTFYVTATEFAIASAARDTDLAWEAVKLLSGAEGQRFLYEEYQELPTWRDADWVDTDLTPYAPAFIAAAEAGRNAFFPEFMFRTFRPWMASIISRALGGASYDLAAELADQQRKAEQWVLDQA
>NC_012669.1|WP_015882009.1|1733888_1735019_-|exo-alpha-sialidase
MTTDAVRNGTTTVKPPPGVVVAHSPAATQAYIGSPSLVRLPGGTLLASHDLFGPGSTWSDTHVYASDDDGATWRHRAHLAGQWWSSLLVHGGALYILGTTTEYGDVVIRRSDDGGRTWTTPDSPRTGLLRQGQFHTAPMPFVEHDGRIWRAMEDASGGEGWGERFAAFVMSAPLGADLLDAASWTSTNALARENAWLPDGFRAWLEGNAVVTPEGELVDVLRVDSADPRVTWGAIVHVSPDGTRATFDPKADLIEMPGGITKFAIRRDPVTGDYVSLVNHVPDPAARSRGLRARNTLALARSADLRTWRVSAPVLEHADDVTHGFQYVDWFIEDGDLLVLSRTAWDEPGGTAHNHHDANYLTFHRLHAFREVPVHA
>NC_012669.1|WP_015882008.1|1732989_1733892_-|dihydrodipicolinate-synthase-family-protein
MSSNHAGPTGVICPIVTPLTDDERLDREVLAAHVRAVLPHVDGLMALGTTGELPVLDDAVADELVDVVLSEVGDAGGQIVLGVGGAGWARTRRNLRRVADGVTHVAVCAPFYYATTPAGLLDYFRRAADAAAVPVVLYNIPQNTHVPLTVDLVATLAEHENVVGIKDSGPSREYFTELLALRSPSFTVLRGTDDAAVLEYRAAGADGFVSGLENIEPGLLRAALEAGDDDARAAAVARIGEIAALADGATGLSAIKAAVAILRGGSPRAARPVPTLEADALRDLAARLEVLGLRPHVAVG
>NC_012669.1|WP_015882007.1|1732099_1732942_-|DeoR/GlpR-transcriptional-regulator
MSSSHAGRRPSARDRARQERQELIASYVLAKGVATPHELTEVSGASIMTVHRDLDELARRGLIRKFHGGVSAKASSVFESSSAFRLHYQSEHKDALAEAVLERIEPGMSVMLDTSSTNVFLARRIARLDDVPLTVITNYQPILHTLRSCDGVSLIMIGGRYSTVHDAFFGIDAVAMTQGLRANLAVLSTSAMTPDETYHQDQDIVLMKRAMMAAADERVLLMDPTKIRRTALHRLAPTRDFDELLLTDPDDPEFVAAVSEHVPTRIVKAARASEDQALEA
>NC_012669.1|WP_015882006.1|1730543_1732118_+|xylulose-kinase
MGGSGGPYVLGLDFGTESCRAAVFDVAGRAVGIAAVPYPTGYPQPGWAEQDPQHWWEAACTAVRRALAESGLSGSEIAGLACDATSLTLVATDAAGTPLRPAILWMDVRAVEQAARADASRSTARRYNGGGTMPASAEWYPFKAAWLKEHEPDVYSRAAHLVDAADWITFRLTGEWTVNLNSAALRMYYDGDNGGWPEDLYDDVGVGDVLGKLTGPVLAPGAPVGELTDDAAAALGLPAGVPVAQGVIDAWAGQIGLGVLAPGRMALITGSSHVFTGQSAEPISGPGFFGAYTDGVVPGEYTVEGGQASTGSVLKWFVEHFAPDVRSASARNGTSPYDVLNERARHLPPGAEGVVVNEYFQGNRTPYTDGDARGMIWGLSLHHGPEHVYRAIQEGVCYGTEHIRRVMADAGHEVHAIVAGGGATRSRDWMQMHADVTGVPITLTHVPDATALGTCVLAAAGAGLFGSVRDAAAAMVRTADVLEPDPDRHEEYGFFVDRYVEAYPLLREPIHAVAARVADQASSA
>NC_012669.1|WP_015882005.1|1729799_1730528_+|glycerophosphoryl-diester-phosphodiesterase
MPVIAVGHRGAAALAPENTLASFARAEEIGVNQLELDLQTSSDGHVVVIHDASVDRTTNGTGAVADLTFEQLRVLDAGDGATIPTFAEVLDATSVSLQVEIKATTAIEPAVELLRQRPEDARRCEPTSFDAATVGRLAELLPDACVGLIRKVAGPDVLDEAASLGARRVLVGLESADEAFVRAARERGFRVDLWPIRTADDVRRVVELGADGFTLDDPRLVADAGFRMTPDGLVGVDVPARS
>NC_012669.1|WP_015882004.1|1728387_1729743_+|ABC-transporter-substrate-binding-protein
MTRSPFGSPSRRTFLGLGAAGLSAPLLASCAGGGSSGELGSVDLNVPSAFSGREVNIAVWSSMSGNNGEVLQGLVTQFNESQEDIYAELQFQGAYEEAGPKVTAALQAKAVPDVMMFADTWWARFMLNDVLEPLDDYFTDDFNGDAYLPSLFQEGVVDGSTYWLSYGRSTPLFYYNKDQFAQAGLPDRGPETWSELLEWAPALNAIQVSGKALATHAFSSGDDWPFMALIWAFGGRISDGLDVQIDGDAAVEAGTWAQDFVFEHGYGYLAQAPTTDFGAGVVATTVGSTASLRGIYEESDFEVGASFLPQEVTTGVPTGGNGFSMFSGVPDERKQAGFELLTFLGRPDNAAAWTLGTGYLPIVTASQEEPELAQVLADDPNFSVAADQLELAQPTDAVRIFVTDSTSTIIGGIQEVLSDRSKDVATTFGGVAGQLRQGAEDIQDSYDRWYG
>NC_012669.1|WP_015882014.1|1739142_1739679_-|hypothetical-protein
MTRGWSQASATFGVALRFFFRHYAAIAAFGALASAQRFLAVSGDERFAFAGGVGGEVFTAVVRLMFLAWLVRTLFRAERAMPWAQLGRRLSRFVAGNAPMLLASAAMLVGLTLVFKVVPELLAADLSPDAHATFLSWELAIKNVTVIPFVMVWVTTIAREALRASDHATDREREPASA
>NC_012669.1|WP_015882015.1|1739747_1740290_+|MarR-family-transcriptional-regulator
MTKSPDDGSAGVPGSRGAPGAPDAAARLGTDLSDAVVLFHEALGSLLGLSAADNKALGIVRREGPMSASELATRTGLTAGAITGLVDRLEGAGLAQRTRDAADRRRLVISATATASPEVAVAIGGLQSGMAEVTSHFTPEQLLVVAEWVDRTSAVLREQAAAIARQRQESAGRPERGPTV
>NC_012669.1|WP_015882016.1|1740328_1741345_+|LacI-family-DNA-binding-transcriptional-regulator
MAVTMRDVAKRAGVSVKTVSNVVSGEYPYIRPETRARVVEAIEDLGYRLNVSARQMRTNRTDVIGLALPELRLQYFAELADEVIRAAAEEGLRVVIEQVEHVEHVAVDHMIGTGAHLLDGAIVAPTSQADVAPESAPRGFPIVVLGDRRIGDDVDQVYLANATGARLAVNHLLDVGCRRIVALGGMPGETTGNAGERTAGYADALAARGVDVDPDLVVPTSAWTMAAGAQSLSAILERGTTFDGVFAFSDSIAIGALGALAQAGVRVPDDVAVVGFDDIDDAAHAVPPLTSVAVDRARTAHEAVRLLVRRLRADTPPPTSAVEIGATLVVRASSTRSA
>NC_012669.1|WP_015882017.1|1741471_1743808_+|alpha-N-arabinofuranosidase
MSMPVTLPTAGGALHRFSPSTAGTASSNGGTSDGAVADNVATDDVAVTFALDTRGVPVSTLLFSQFLEHMSYATIGGLSAELVVNPTFHPDHHLRADQIAQLRANADAAVAWALGDPTPIRHRWVSSPLASGWSVTLFDDETARGLPLGWGALGRPGAVRRAVGRVGGAVRIDGPGGAADDGGAADDGVAHLGRATVPLDGTVAGIRQAVYVPTHRTRRVHVRLWARAETTLAHVEVGLRRRLSTAPARPAGQVLANATIAVGPHDWGPQDVILEVDGDALARHEPCDLYVLDHGGDAVVVDRISVLPTDHVHGLDPEILDIARRARIGELRWPGGNFVSHYHWRDGVGPLDLRPTRANPAWGGLETNLIGTDEYLRLCELLDATPHITVNTGTGTPEEAAAWVEYCNGAPDTPMGRLRAANGHPEPYGVTVWEVGNENFGAWQGGFTGSEENARRFAQFATAMRAVSPIPLRLHACGNWSDLVPPSVAHDDVACDGRWHSELLRQAAGDVDVISLHPLPINDRGLEGVSEDEAHAAVMAQVVTAERESLPRLLAECDAVRADPPIRLSITEWGPIGENPARINVENVGGAVWGATMLATAIRFGERIESASANGFHHGGAIKKGAGVVYTDPVVDVVVRLREFAGWTPVGIETHGPGHDVAIGTDLGVPERDVPDVDVLGLLSPDASRLVVMAVNRRLGAPRHVRLRRPDGWGRASAELLVGPQVFDRASPVDPDPFPWTPAHLDPETGTDGGVTGLTVPPVAVALVHLERTPDGTT
>NC_012669.1|WP_015882018.1|1743858_1745124_+|ABC-transporter-substrate-binding-protein
MSKLIRVAALAAAGALTLAACASGGGDAGDDGGQAGPVEITFWNGFTSSDRPIVEQLVAEFNDSQDDYRVRMEIQPWDTMYSKLMPAYQAGEGPTLVAMDPARTPAYVERGVLAPVDDFYGDGALDAATLPEASLEANMYDGVQYGVPMSAGAGMLYWNADIFAAAGIEGPPETWAELADVAVQLTEGDQYGLPIADHEALSLWPTLFWADGGGIFTDDSSASLLGDDATVATMEFWTDLVQNEGISPAGLSGADADALMLAGSAAMHMTGPWLSSGLTEAGINWEVAPLPAGTSGQFSPAVIVNMHLDANATDAEREAARAFVTHWNSPEAQTTWAVGTSYPPNRTDIPASDLAENPTSAAFTEAIGPRFYQAGLLNFADLDANVVTPTIQRVLAGEGTAADLFPEAAEQLDSQIETLGE
>NC_012669.1|WP_015882019.1|1745120_1746086_+|sugar-ABC-transporter-permease
MTAALPSASAPSAPARGSAGGPGGRRVGRRSTIERRRTRTAVAFLLPAVLILAVFVFWPIANALRTSFTDEAFLPVTNWVGLDNYIRLADDERFWGALRNTAVYTAVTAPVSVAIALGLALLLNRPMRGRAAFRAILFFPWVASLGITSIAWAALVDPQIGMLTSWLRWFGISIGDGLRDPEFAMAAVMFVGIWRNVGFFMVMYLAGLQQIPGHLEEAALLDGAGAWQKFRNVTWPLLANTTMFVVVIAAVFSFQAFDQIYVMTAGGPYFRTETLVMLIYGSAVRDFDVGYATAVSWVLVLIVLTLSLIQMRYFSKRVVQY
>NC_012669.1|WP_015882020.1|1746085_1746982_+|carbohydrate-ABC-transporter-permease
MTTATLPSRSTSPSRPAGPFRAGRARATTATRTLVTWFALAAASAVVLLPLAWMLSASLRTQGDLVGSPSSLIPTNVTFENYVEIWQLIPFGRLFLNTVVFAGVVACVSVVIDAMAGYALARFDFPGRTFVFVALVATLLVPIQVTFVPVYSLLIDLGWVNTLHGLIVPRIADAFGIFFLRQYFLALPKDLEDAARIDGASEVRIFRSIMFPLAGPALLTIFMFNLVGNWNDLLWPLIVMSDPQSTTLPVGLALFRGQHVIEYGPLMAGSVLALIPMVIAFVVVQRRFIESIATTGIK
>NC_012669.1|WP_015882021.1|1747077_1750608_+|ABC-transporter-ATP-binding-protein
MIDAPLAPTRDQAAPARRAIDPSRRLDWRRLRGVVTVLALLALAVATVGTALGTVVAGRLAQEATAAGVLLLAGCLVGAALLDTLGYVSWAGVVDKAEGRLRGDLLSAALHQPLAALTEQAVGEVLDRVDDDTHALGTLVRRQMWGMGRTLVGSLPLWIVAGLTWWPAWILFPALAAVTLLVVRPMLGEIARRKVVEERAWTDNAAAFEEAVAARDDLRTSGGQAFAVRRLAEMSAAVHRTLDRVLQVETSMTWRAGSLLHALLAGVAVSGAALAVGGDVSVGQLVTLFLVTSTFVGQVDQLAHHLPDLQEGVGAAIRVRQLLEAESEPTGGRTLPDEPLDLELRDLHFAYAEGTFALQDVSLRVPAGHTVALVGRTGSGKSTLASLLSRAVDPEPGTVFLGGHDVRDLDLQDLRRRVGVVTQRTEILAGTLAENITLFAHLPRADVEAAVAELGLTDWVAGLPDGLDTLLGPGGTSLSAGEEQLVAFARLLVADVQVVVLDEATARMDPLTEARVIAASERLLGGRTGVLVAHRLGTVERAELVVVLDHGRVVQQGARVALAAQDGPFRSLLEASRVAEAEHGGGSAGEDHATLDTAVGARRRTGPPPDLPDPGTGPSLARGIAHALLVRPRWGILGGALFLVASLVSAQGAITGYLWGRAVTDLERGATPAVLVGVMAVLLLVVPLCHAGAMRIYPKWWVEVLLRIRTAVLVGQTNQHRLRRTPPGEVVARALDADRYVRYADRWVDLTNGLVIVVVTTLLSGSLLAGAVLLAVLVVTAVCAVAGRPIAGRTAARASTARARFGRALVSALDAARTVKLAARTPQVHDHLRGVDAGRVRAAVFEHRVQAVLDGVPVIAVQAGVVVAWAALLSGTWNLATTLLVAAAVSGFNWFGVVAGAVVTEAPGTRAWQRSTGAFAGGTDLTVLPPDVDLSTGGAPAPSAAAREQLRALELRGLTAVHDDGTIGVENVDLAVHRGELVLLLGQVGSGKSSLLSSLAGLMEHTGSVTWNGAEVDDAQLFLRPGRVAHVAQVPRVLSGTFAENVRLDHAERDVAGPIDAARLTMDVEDAGGADAVVGHRGVRLSGGQVQRLALARALATDSELLLADDVSSALDAATEIELWDSLRERGTTVVGATSKRAALARADRVVVLADGAVAAVGPWRELAGRWGHLAG
>NC_012669.1|WP_015882022.1|1750761_1752132_-|alkaline-phosphatase-family-protein
MSAPHKLLVVSVDAMVGDDVEFARTLPAFGRLLRDAATAQIEAVFPTLTYPNHTAQLTGAGPASSGIYNNTQFQPHEADPDWFWSAHHVRVPTLLDAARRAGLRTAAVQWPATAHADIDTLVPEIWDREYWGGVQEMYRATGSPDVWETYVAKHVDLVVWEPKRDFNDFACAVAADVLERERPDVMVLHLVAVDAARHATGPFSPQVHDALRRIDGYLGRLLDVLEHTGELERTNVVLVSDHGHLAVEQHTQLNAVFAERGFLRIDGAGRLLDYDVICHSAGLSGQLFLAEDLSPARLADVAALLRDLEADPQYRIAAIHTAAEAASRYGLDGPFAYVVESEPGVLVGRDWTSRPVVRREDADFAGYLGNHGHAPQHGGSRCSSRPGRRSRRGRTRGAVRSSTRRRRSPRCSAWSCRTPKAPRCPSCSSALAWGRPSPRKSPVLCGAVGDGRDLRH
>NC_012669.1|WP_015882023.1|1752128_1753526_-|extracellular-solute-binding-protein
MPSPSSLHLSRRTLLSTLGVSAAGLGLAACGAPGGGSGGSGAESSSNLRDGFSQAPVTNVPSQYSGRTNILFWAPFTGVNFEVVQEQFTAFNDSQDEIYAAAESQADYATLNQKFTAALQARQVPDIVCFPEMQWLQFHFSDALAPLDGYFDDEWSLDVYLDNYVGEGVAAGQTYVVPFARSTPLFYFNKTRFLELGLPETGPATWDEFAEFAPELKSISVAGQPLMPMAFGTGDNWYGQAHAWAWGGALSDDLTVTVDSEQMHDWLTWKAGFIHDDGFGYMAQSAMTDFQTGLAAACHGSTASLRGATEASDFEIGTAFMLGKLEDSTKVPTGGSGLSIVKAESQERQDACAELFRFLADPEMSAQWHAGTGYLPIVKASHDTATVQDLVAADPNFGVALAQLPNAQTADQPVWYQSGATELGAAMAQVYGDNADVAGVLGGLQATFEEVIEDNREDLEEVMSA

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Crispr_ID: NC_012669_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012669_7

1750668-1750757

Orphan

Consensus_repeat	Method
GGGCCTACGGCAGTGACCCGTGTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012669_7

>merge|NC_012669|7|1750668-1750757|CRISPRCasFinder
GGGCCTACGGCAGTGACCCGTGTGGCGGGTCACTGCCGTAGCGCGGAGGGCTGCGGCGGTGGCGTGGGCCTACGGCAGTGACCCGCGTGG

>NC_012669|7|7|1750668-1750757|CRISPRCasFinder
GGGCCTACGGCAGTGACCCGTGTGG	CGGGTCACTGCCGTAGCGCGGAGGGCTGCGGCGGTGGCGT
GGGCCTACGGCAGTGACCCGCGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012669.1\|WP_015882021.1\|1747077_1750608_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_012669.1\|WP_050761690.1\|1763615_1765001_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224525
NC_012669.1\|WP_015882028.1\|1760273_1761191_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012669.1\|WP_015882022.1\|1750761_1752132_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|293742
NC_012669.1\|WP_144016905.1\|1737260_1738085_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NC_012669.1\|WP_144016906.1\|1761198_1762002_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NC_012669.1\|WP_015882014.1\|1739142_1739679_-\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_187292876.1\|1754482_1755481_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_012669.1\|WP_015882024.1\|1753562_1754486_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012669.1\|WP_187292875.1\|1738243_1738915_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_012669.1\|WP_015882030.1\|1762163_1763474_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|224567
NC_012669.1\|WP_015882026.1\|1755741_1757760_+\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|176519
NC_012669.1\|WP_015882015.1\|1739747_1740290_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_012669.1\|WP_015882020.1\|1746085_1746982_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012669.1\|WP_015882027.1\|1757892_1760247_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NC_012669.1\|WP_015882019.1\|1745120_1746086_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_012669.1\|WP_015882016.1\|1740328_1741345_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_012669.1\|WP_015882017.1\|1741471_1743808_+\|alpha-N-arabinofuranosidase	unknown	unknown	gnl\|CDD\|226064
NC_012669.1\|WP_015882023.1\|1752128_1753526_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270451
NC_012669.1\|WP_015882018.1\|1743858_1745124_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270451

Protein	Function_ID	Function_description	E-value
NC_012669.1\|WP_015882021.1\|1747077_1750608_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.14032e-93
NC_012669.1\|WP_050761690.1\|1763615_1765001_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.22357e-85
NC_012669.1\|WP_015882028.1\|1760273_1761191_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.28786e-83
NC_012669.1\|WP_015882018.1\|1743858_1745124_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.69858e-93
NC_012669.1\|WP_144016905.1\|1737260_1738085_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	7.98457e-74
NC_012669.1\|WP_144016906.1\|1761198_1762002_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	7.58229e-66
NC_012669.1\|WP_187292876.1\|1754482_1755481_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	6.00801e-83
NC_012669.1\|WP_015882024.1\|1753562_1754486_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.0945e-80
NC_012669.1\|WP_187292875.1\|1738243_1738915_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	3.48969e-37
NC_012669.1\|WP_015882030.1\|1762163_1763474_-\|extracellular-solute-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	4.0096e-34
NC_012669.1\|WP_015882026.1\|1755741_1757760_+\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|176519	cd08577, PI-PLCc_GDPD_SF_unchar3, Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases. This subfamily corresponds to a group of uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipase C (PI-PLC), and glycerophosphodiester phosphodiesterases (GP-GDE), and also sphingomyelinases D (SMases D) and similar proteins. They hydrolyze the 3'-5' phosphodiester bonds in different substrates, utilizing a similar mechanism of general base and acid catalysis involving two conserved histidine residues.	4.75834e-96
NC_012669.1\|WP_015882015.1\|1739747_1740290_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.09918e-15
NC_012669.1\|WP_015882020.1\|1746085_1746982_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.62804e-84
NC_012669.1\|WP_015882027.1\|1757892_1760247_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	5.12967e-108
NC_012669.1\|WP_015882019.1\|1745120_1746086_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.88412e-91
NC_012669.1\|WP_015882016.1\|1740328_1741345_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.08865e-86
NC_012669.1\|WP_015882017.1\|1741471_1743808_+\|alpha-N-arabinofuranosidase	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	1.87137e-62
NC_012669.1\|WP_015882023.1\|1752128_1753526_-\|extracellular-solute-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.7284e-67
NC_012669.1\|WP_015882022.1\|1750761_1752132_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|293742	cd16018, Enpp, Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin. Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.	1.59565e-65

>NC_012669.1|WP_015882021.1|1747077_1750608_+|ABC-transporter-ATP-binding-protein
MIDAPLAPTRDQAAPARRAIDPSRRLDWRRLRGVVTVLALLALAVATVGTALGTVVAGRLAQEATAAGVLLLAGCLVGAALLDTLGYVSWAGVVDKAEGRLRGDLLSAALHQPLAALTEQAVGEVLDRVDDDTHALGTLVRRQMWGMGRTLVGSLPLWIVAGLTWWPAWILFPALAAVTLLVVRPMLGEIARRKVVEERAWTDNAAAFEEAVAARDDLRTSGGQAFAVRRLAEMSAAVHRTLDRVLQVETSMTWRAGSLLHALLAGVAVSGAALAVGGDVSVGQLVTLFLVTSTFVGQVDQLAHHLPDLQEGVGAAIRVRQLLEAESEPTGGRTLPDEPLDLELRDLHFAYAEGTFALQDVSLRVPAGHTVALVGRTGSGKSTLASLLSRAVDPEPGTVFLGGHDVRDLDLQDLRRRVGVVTQRTEILAGTLAENITLFAHLPRADVEAAVAELGLTDWVAGLPDGLDTLLGPGGTSLSAGEEQLVAFARLLVADVQVVVLDEATARMDPLTEARVIAASERLLGGRTGVLVAHRLGTVERAELVVVLDHGRVVQQGARVALAAQDGPFRSLLEASRVAEAEHGGGSAGEDHATLDTAVGARRRTGPPPDLPDPGTGPSLARGIAHALLVRPRWGILGGALFLVASLVSAQGAITGYLWGRAVTDLERGATPAVLVGVMAVLLLVVPLCHAGAMRIYPKWWVEVLLRIRTAVLVGQTNQHRLRRTPPGEVVARALDADRYVRYADRWVDLTNGLVIVVVTTLLSGSLLAGAVLLAVLVVTAVCAVAGRPIAGRTAARASTARARFGRALVSALDAARTVKLAARTPQVHDHLRGVDAGRVRAAVFEHRVQAVLDGVPVIAVQAGVVVAWAALLSGTWNLATTLLVAAAVSGFNWFGVVAGAVVTEAPGTRAWQRSTGAFAGGTDLTVLPPDVDLSTGGAPAPSAAAREQLRALELRGLTAVHDDGTIGVENVDLAVHRGELVLLLGQVGSGKSSLLSSLAGLMEHTGSVTWNGAEVDDAQLFLRPGRVAHVAQVPRVLSGTFAENVRLDHAERDVAGPIDAARLTMDVEDAGGADAVVGHRGVRLSGGQVQRLALARALATDSELLLADDVSSALDAATEIELWDSLRERGTTVVGATSKRAALARADRVVVLADGAVAAVGPWRELAGRWGHLAG
>NC_012669.1|WP_015882020.1|1746085_1746982_+|carbohydrate-ABC-transporter-permease
MTTATLPSRSTSPSRPAGPFRAGRARATTATRTLVTWFALAAASAVVLLPLAWMLSASLRTQGDLVGSPSSLIPTNVTFENYVEIWQLIPFGRLFLNTVVFAGVVACVSVVIDAMAGYALARFDFPGRTFVFVALVATLLVPIQVTFVPVYSLLIDLGWVNTLHGLIVPRIADAFGIFFLRQYFLALPKDLEDAARIDGASEVRIFRSIMFPLAGPALLTIFMFNLVGNWNDLLWPLIVMSDPQSTTLPVGLALFRGQHVIEYGPLMAGSVLALIPMVIAFVVVQRRFIESIATTGIK
>NC_012669.1|WP_015882019.1|1745120_1746086_+|sugar-ABC-transporter-permease
MTAALPSASAPSAPARGSAGGPGGRRVGRRSTIERRRTRTAVAFLLPAVLILAVFVFWPIANALRTSFTDEAFLPVTNWVGLDNYIRLADDERFWGALRNTAVYTAVTAPVSVAIALGLALLLNRPMRGRAAFRAILFFPWVASLGITSIAWAALVDPQIGMLTSWLRWFGISIGDGLRDPEFAMAAVMFVGIWRNVGFFMVMYLAGLQQIPGHLEEAALLDGAGAWQKFRNVTWPLLANTTMFVVVIAAVFSFQAFDQIYVMTAGGPYFRTETLVMLIYGSAVRDFDVGYATAVSWVLVLIVLTLSLIQMRYFSKRVVQY
>NC_012669.1|WP_015882018.1|1743858_1745124_+|ABC-transporter-substrate-binding-protein
MSKLIRVAALAAAGALTLAACASGGGDAGDDGGQAGPVEITFWNGFTSSDRPIVEQLVAEFNDSQDDYRVRMEIQPWDTMYSKLMPAYQAGEGPTLVAMDPARTPAYVERGVLAPVDDFYGDGALDAATLPEASLEANMYDGVQYGVPMSAGAGMLYWNADIFAAAGIEGPPETWAELADVAVQLTEGDQYGLPIADHEALSLWPTLFWADGGGIFTDDSSASLLGDDATVATMEFWTDLVQNEGISPAGLSGADADALMLAGSAAMHMTGPWLSSGLTEAGINWEVAPLPAGTSGQFSPAVIVNMHLDANATDAEREAARAFVTHWNSPEAQTTWAVGTSYPPNRTDIPASDLAENPTSAAFTEAIGPRFYQAGLLNFADLDANVVTPTIQRVLAGEGTAADLFPEAAEQLDSQIETLGE
>NC_012669.1|WP_015882017.1|1741471_1743808_+|alpha-N-arabinofuranosidase
MSMPVTLPTAGGALHRFSPSTAGTASSNGGTSDGAVADNVATDDVAVTFALDTRGVPVSTLLFSQFLEHMSYATIGGLSAELVVNPTFHPDHHLRADQIAQLRANADAAVAWALGDPTPIRHRWVSSPLASGWSVTLFDDETARGLPLGWGALGRPGAVRRAVGRVGGAVRIDGPGGAADDGGAADDGVAHLGRATVPLDGTVAGIRQAVYVPTHRTRRVHVRLWARAETTLAHVEVGLRRRLSTAPARPAGQVLANATIAVGPHDWGPQDVILEVDGDALARHEPCDLYVLDHGGDAVVVDRISVLPTDHVHGLDPEILDIARRARIGELRWPGGNFVSHYHWRDGVGPLDLRPTRANPAWGGLETNLIGTDEYLRLCELLDATPHITVNTGTGTPEEAAAWVEYCNGAPDTPMGRLRAANGHPEPYGVTVWEVGNENFGAWQGGFTGSEENARRFAQFATAMRAVSPIPLRLHACGNWSDLVPPSVAHDDVACDGRWHSELLRQAAGDVDVISLHPLPINDRGLEGVSEDEAHAAVMAQVVTAERESLPRLLAECDAVRADPPIRLSITEWGPIGENPARINVENVGGAVWGATMLATAIRFGERIESASANGFHHGGAIKKGAGVVYTDPVVDVVVRLREFAGWTPVGIETHGPGHDVAIGTDLGVPERDVPDVDVLGLLSPDASRLVVMAVNRRLGAPRHVRLRRPDGWGRASAELLVGPQVFDRASPVDPDPFPWTPAHLDPETGTDGGVTGLTVPPVAVALVHLERTPDGTT
>NC_012669.1|WP_015882016.1|1740328_1741345_+|LacI-family-DNA-binding-transcriptional-regulator
MAVTMRDVAKRAGVSVKTVSNVVSGEYPYIRPETRARVVEAIEDLGYRLNVSARQMRTNRTDVIGLALPELRLQYFAELADEVIRAAAEEGLRVVIEQVEHVEHVAVDHMIGTGAHLLDGAIVAPTSQADVAPESAPRGFPIVVLGDRRIGDDVDQVYLANATGARLAVNHLLDVGCRRIVALGGMPGETTGNAGERTAGYADALAARGVDVDPDLVVPTSAWTMAAGAQSLSAILERGTTFDGVFAFSDSIAIGALGALAQAGVRVPDDVAVVGFDDIDDAAHAVPPLTSVAVDRARTAHEAVRLLVRRLRADTPPPTSAVEIGATLVVRASSTRSA
>NC_012669.1|WP_015882015.1|1739747_1740290_+|MarR-family-transcriptional-regulator
MTKSPDDGSAGVPGSRGAPGAPDAAARLGTDLSDAVVLFHEALGSLLGLSAADNKALGIVRREGPMSASELATRTGLTAGAITGLVDRLEGAGLAQRTRDAADRRRLVISATATASPEVAVAIGGLQSGMAEVTSHFTPEQLLVVAEWVDRTSAVLREQAAAIARQRQESAGRPERGPTV
>NC_012669.1|WP_015882014.1|1739142_1739679_-|hypothetical-protein
MTRGWSQASATFGVALRFFFRHYAAIAAFGALASAQRFLAVSGDERFAFAGGVGGEVFTAVVRLMFLAWLVRTLFRAERAMPWAQLGRRLSRFVAGNAPMLLASAAMLVGLTLVFKVVPELLAADLSPDAHATFLSWELAIKNVTVIPFVMVWVTTIAREALRASDHATDREREPASA
>NC_012669.1|WP_187292875.1|1738243_1738915_-|GntR-family-transcriptional-regulator
MDVTPLQQEALGDRVARALRRKIVSGELERGTHLVEGPLSESFGVSRGPIRDALRALESDGLVESRRRGAFVVGLDENDIDELYSLREVLEAFALDLVLEQERLDRTPFVDAVEAMRDAAQRGDSASFAEADVMFHRLFYTASHHRRLHAMWHTLEPTFVALLEISTAQDDDLGPSAESHAQILDAVLAGDGDSARTELGAHLLGARSRITAAHQRRTGRPAT
>NC_012669.1|WP_144016905.1|1737260_1738085_-|ABC-transporter-permease-subunit
MLVALAAFTLYPLVETARLSFTDSNGVQASYVGLDNYTYIFSDDLFWSALSNTVYMGALTIVIGIPLSLVIATLINSLPATQSLFKAVYFAPNITSAIAAAIAFTYVFYPTEQGWVNALLGQLGLGPFGFFSDPGTARASVVLMSVWQGLGYTTLIWLAGLQGVPRELHEAAEVDGAGSLRRWWSVTLPMLRPITFFIIVVESINAFKRFADVYQIGGTDGQPGGVLTTIMLYIYRTGFNTFDFGKASAATVVLFLIILALTCVNFALFRRRLS
>NC_012669.1|WP_015882022.1|1750761_1752132_-|alkaline-phosphatase-family-protein
MSAPHKLLVVSVDAMVGDDVEFARTLPAFGRLLRDAATAQIEAVFPTLTYPNHTAQLTGAGPASSGIYNNTQFQPHEADPDWFWSAHHVRVPTLLDAARRAGLRTAAVQWPATAHADIDTLVPEIWDREYWGGVQEMYRATGSPDVWETYVAKHVDLVVWEPKRDFNDFACAVAADVLERERPDVMVLHLVAVDAARHATGPFSPQVHDALRRIDGYLGRLLDVLEHTGELERTNVVLVSDHGHLAVEQHTQLNAVFAERGFLRIDGAGRLLDYDVICHSAGLSGQLFLAEDLSPARLADVAALLRDLEADPQYRIAAIHTAAEAASRYGLDGPFAYVVESEPGVLVGRDWTSRPVVRREDADFAGYLGNHGHAPQHGGSRCSSRPGRRSRRGRTRGAVRSSTRRRRSPRCSAWSCRTPKAPRCPSCSSALAWGRPSPRKSPVLCGAVGDGRDLRH
>NC_012669.1|WP_015882023.1|1752128_1753526_-|extracellular-solute-binding-protein
MPSPSSLHLSRRTLLSTLGVSAAGLGLAACGAPGGGSGGSGAESSSNLRDGFSQAPVTNVPSQYSGRTNILFWAPFTGVNFEVVQEQFTAFNDSQDEIYAAAESQADYATLNQKFTAALQARQVPDIVCFPEMQWLQFHFSDALAPLDGYFDDEWSLDVYLDNYVGEGVAAGQTYVVPFARSTPLFYFNKTRFLELGLPETGPATWDEFAEFAPELKSISVAGQPLMPMAFGTGDNWYGQAHAWAWGGALSDDLTVTVDSEQMHDWLTWKAGFIHDDGFGYMAQSAMTDFQTGLAAACHGSTASLRGATEASDFEIGTAFMLGKLEDSTKVPTGGSGLSIVKAESQERQDACAELFRFLADPEMSAQWHAGTGYLPIVKASHDTATVQDLVAADPNFGVALAQLPNAQTADQPVWYQSGATELGAAMAQVYGDNADVAGVLGGLQATFEEVIEDNREDLEEVMSA
>NC_012669.1|WP_015882024.1|1753562_1754486_-|carbohydrate-ABC-transporter-permease
MSLDVRPLPTASSAVADAALSADVPTTAPPRRVRRPLAVRLALYVLLALTLTVFVLPLVWLFTSAVKPEHDIYVYPLQWIPTALELANFSDAWTAAPFDRFFLNSLITTVSGTTLEVGLAVLSAYAFAFVRFRWKTPLFLLMLGSMMLPGHVTLLVNYITVGNLGWLNTYLGIVLPGIGSAFAMFLIYQQMRRVSDEVVDAAKLDGAGHLRRMWSVVIPMSRPMILTGTLIVMFAKWNDYVWPLIVTSTVDMRTLPIGLMFLRSQEGYTNWGAIMAGTVMVALPMLLIFFVAQRRIIGGLAAGATKG
>NC_012669.1|WP_187292876.1|1754482_1755481_-|sugar-ABC-transporter-permease
MHDPAPPCAAGGAAVTAVVDPPRPGQAAVAAPSRPVTRNRRRSNRREALLFGALILPNLAAILVFSYYPTIYNVVLSFMDWDMVAAAPEWIGLANYQDLFTSDDFYTVLGNTAIFTGVAVVGSLAGGLAIGQLLSQRLKFSGFTRTMAFAPHMLPGAAVGILWLFMFDPTYGLSRWFFGLFGLTSPSWTTTSDWSIWAITIAYTWQRLGFVAIIYYTAIQDLPRDVYEAAELDGARGFGLFWSITRPLLSPVTFFLTVTGIISAAQAFDIIATLTGGGPGNSSATLTWMVYEEAFQRFDVGTSAAAATVLFLVLLGVTIVQTRTAGRQVHYS
>NC_012669.1|WP_015882026.1|1755741_1757760_+|endonuclease/exonuclease/phosphatase-family-protein
MAVARSAVAVLSTLAVAALGLTLAVTPAAAGGGGSGGGSGGGSGGGGPSLRVATFNASLNRAAAGELVADLSTPDDAQAATIAEILQRNRPDVVLLNEFDYVPDHVAVDLFRDNYLEVSQGGAEPIEYPYAYVAPSNTGIPSGFDLNNDGTVGGGDDALGFGLFEGQYGMVVLSRYPIVERDVRTFQTFLWKDMPGALLPDDPATPEPADWFTPEELDVVRLSSKSHWDVPVRVGRDTVHVLASHPTPPTFDGPEDRNGLRNHDEIRFWADYVTPGRASRYIVDDDGERGGLSRNASFVVVGDQNADPLDGDSVDAAIDQLLDHRWITDPLPTSDGAVEAASLQGGANTAHAGDPAYDTADFADTAPGNLRADYVLPSRDLRVRDAGVFWPVAADPLSRLTGVFPFPSSDHRLVWVDLGDPVLGEPLAQAHAHNDYEHDRPLYDALEHGFTSVEADVWLVDGELLVAHDAVDLDPERTLESLYLDPLDELVRGRHDSVYPRWDGTFQLLIDIKTEAESTYAAIEAALGEHRDLFARYSRGRVHDGPVRAVISGNRPLETMAAADRRYGFYDGRSGDLGSGLPASLMPLVSDNWANLFTWQGVGEMPAGERDALHAYVAQAHDAGYRVRFWNTPDAAGPARDAVWAELRDAGVDHINTDDLAGLEAFLDDDDA
>NC_012669.1|WP_015882027.1|1757892_1760247_-|FAD-dependent-oxidoreductase
MRHREERAQVVVCGGGLAGVSAAVSAARLGLRTVLVQDRPVLGGNSSSEVRVVPRGAGNYHAYARETGVVGDLLERERLLNHEEIFENGFTNSVWDLTMYDLVERTPNLTLHLNTAVRDVVLGAGQRIEAVVGYTASAETETTFSGDVFVDCTGDGVVAALAGAPWRMGTEGRAEFGEPHAPEAASDDVMGNSIHIKTKDVGRPVEFELPDWAVRYDDAAFFYRGGRRPSTLKGGYWWIEIGVPWHTIHDAETIRHELTRHALGVWDWIKNSDPHLRERARTYALDWIGQVPGKRESRRIMGQHLMTEADLFRAEPHRDEIAYGGWNIDLHTPGGLLAETSEPTAAEGHLTTAPAAVAAYVGPFGIPLRSLIALDVPNLLMAGRNVSATHVALGSVRVQATTAIMGQAAGTAAAIAVRDGVAVHSVASEAIDAVQQQLLRDGAFLPSVANADPLDLARTARVRASSTALAYGADPDAVGVTGGLGNHSKPGDALAEVRGQWIAVGTGADAPGLDSVAVCLTNPTPEARTIGARLLAVDHIWDYRIDDAPVLAKADLVVPPGERVWVTWDVALGADELGSSDDGVDVRYVRLDLDADPDISWHRAGSVVPGSVSGVRIASGRMRRYLDAVTLAHRVSPPQPAWPASQALTGVTRPHRSTNVWRSDPAQPFDQWLELAWDAEREVGRVELTFAGSVLREYDRCPPGYRDPQGARSYSIEVLGSAGTVDDGDWRRVLTVTDNAARRRGHDLPGVVATRALRLVVHATNGDPSAAVAEVRCYAEPLRA
>NC_012669.1|WP_015882028.1|1760273_1761191_-|carbohydrate-ABC-transporter-permease
MATTAPTPAHLTRATPSPAVPPARRRPARRAPLATFAWHGLMLLLCVATLYPLLWMARSSVVPEEEIFASPTIVPSGVDLASYPAGWNANPPGFGTFLTNSFLICAGAVAGNLIACTLAAYAFARLRFPLKKVWFAVMLGTVMLPGHVTLIPQYALFSAVGWVGTYLPLIVPKFLATDAFFIFLLVQFMRGIPRELDEAAEIDGAGRWRAFRSVMLPLTVPALATTAVFTFIWTYEDFLGPLIYLSDLNDYPVPLGLRMFVNAMGQSSYGQLFAMSLVSLLPVFVFFLLFQRKLIAGIATTGLKG
>NC_012669.1|WP_144016906.1|1761198_1762002_-|ABC-transporter-permease-subunit
MAASAYLSFTSYDLFNDPVWVGFDNYRTMFTDDPRHLQSLRVTFTYVLASVPLRLAVALGLAVLMNRTLRGMSFYRAALYLPSLLGGSVAIAILWRQLFGGEGAINQILAFLGISGPNWIASPSTSLLTLIVLAVWQFGSPMVIFLAGLRQIPAELLEAARVDGAGTVRRFASVTLPLLTPLVFFNLVMQTIVAFQAFTPSFIISNGTGGPVDSTLFYTLYLYIKGFGEFEMGYASAMAWVLVAIIATFTAINFLGARRWVHYADES
>NC_012669.1|WP_015882030.1|1762163_1763474_-|extracellular-solute-binding-protein
MKSTRHTPRRTIRRPAAAAAVTASLALALAACGVGGGDAPGADETVGPASDAPIRATWWGVDNQNQALDAAIASFTEAGGPEVAVEPQPWDGYWDKLATLVAGRDLPDVVMQAASQLPTYAERDSLLDLSQVDLDTSGLDAGIRDFGTVGDASFGVVAATNATGFVTNADLLGELGVDAPAGEWTWDDLAAFADQVRMASAGETWGVQDGSGDLILFILYVRDSGREFYADDGSLNATPDDLRAWLQLWADMREAGSVPPADVTAESAGNMPGSPLATGRAAASFAWTQDYVALQAVTDSALDIGLPPHNTEHPSLWINAASLWSISATSGNPQGAADLIDHLVNDPGAVEELGATLGIPPTAEARAQIAESVTDEELPAVEYMDIVAENSRPLNRLWPDGFADSRTLLGQLAEAVAFGQTSIDDAVDAFFADAEG
>NC_012669.1|WP_050761690.1|1763615_1765001_+|substrate-binding-domain-containing-protein
MSDPVSPSGGPPGAPQEEAQAAPGRSARAGKAVGIKDVAARAGVSWKTVTNVIHGRPNVAPATRRRVERAIAELGYRANLAGRQLRHGRTGLLAVSVPDLATPYYADLARSVVQRARKDDYTVLVDETGHSIARETSAARGYPVRFTDGVLLSPSRLTGPEIAALRTDTPLVLLGEQADSGGLDQVSIDNVGSAREATRHMLTLGRRRLAFLGAEIGPHRKASSLRIAGVRAELAAWGGDAELALVETSEYSRSEGFARTRREYEAGARHDALICATDLLAVGALHALAMLGLRSPDDVAVLGWDNAPEGEYAWPPLTTIAPDMAEFGSQAINLLLARIVEPAAPARRSVVNHRLVVRASTLGSAATFNPAVPYQIRHERPSPGELIREARVRAGLTQSALASQIGSSQALIARYEADAVSPTVRSLDRILEALGSDLEIGSRPPAAPRAQAGVKGVRQNG

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Crispr_ID: NC_012669_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012669_8

3649893-3650076

Orphan

Consensus_repeat	Method
CCGTGTGGTTCGTCCTGCGAAGGCCCGACACACAGGACGAACCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012669_8

>merge|NC_012669|8|3649893-3650076|CRISPRCasFinder
CCGTGTGATTCGTCCCTCGAGGGCCCGACACGGAGGACGAACCACACGCTCGCACCACCGCCCACACTGACCGTGTGGTTCGTCCTGCGAAGGCCCGACACACAGGACGAACCACACGCTCGCACCACCGCCCACACTGGCCGTGTGGTTCGTCCCGCGAAGGCCCGACACACAGGACGAACCA

>NC_012669|8|8|3649893-3650076|CRISPRCasFinder
CCGTGTGATTCGTCCCTCGAGGGCCCGACACGGAGGACGAACCA	CACGCTCGCACCACCGCCCACACTGACCGTGTGGTTCGTCCTGCGAAGGCCCGACACACAGGACGAACCACACGCTCGCACCACCGCCCACACTGG
CCGTGTGGTTCGTCCCGCGAAGGCCCGACACACAGGACGAACCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012669.1\|WP_043350272.1\|3652713_3653529_+\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_015883768.1\|3642925_3643900_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NC_012669.1\|WP_015883774.1\|3651431_3652370_-\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_015883772.1\|3648296_3649763_-\|glycoside-hydrolase-family-43-protein	unknown	unknown	gnl\|CDD\|350153
NC_012669.1\|WP_015883773.1\|3650200_3651412_+\|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl\|CDD\|376451
NC_012669.1\|WP_015883782.1\|3659477_3660419_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012669.1\|WP_015883778.1\|3654670_3656716_+\|beta-galactosidase	unknown	unknown	gnl\|CDD\|367090
NC_012669.1\|WP_015883776.1\|3653553_3653862_-\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_015883764.1\|3639736_3641446_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|283837
NC_012669.1\|WP_015883779.1\|3656744_3657167_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|211538
NC_012669.1\|WP_015883766.1\|3641869_3642364_+\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_015883770.1\|3645846_3646605_+\|aquaporin-family-protein	unknown	unknown	gnl\|CDD\|223653
NC_012669.1\|WP_083770072.1\|3657322_3657934_+\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|367243
NC_012669.1\|WP_015883771.1\|3646664_3648182_+\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|198362
NC_012669.1\|WP_015883765.1\|3641442_3641739_-\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_015883781.1\|3657940_3659392_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NC_012669.1\|WP_015883767.1\|3642374_3642929_-\|amino-acid-N-acetyltransferase	unknown	unknown	gnl\|CDD\|236132
NC_012669.1\|WP_015883763.1\|3639292_3639721_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374742
NC_012669.1\|WP_050761902.1\|3644063_3645761_+\|glycerol-3-phosphate-dehydrogenase/oxidase	unknown	unknown	gnl\|CDD\|223651
NC_012669.1\|WP_144016808.1\|3653997_3654690_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223645

Protein	Function_ID	Function_description	E-value
NC_012669.1\|WP_015883778.1\|3654670_3656716_+\|beta-galactosidase	gnl\|CDD\|367090	pfam02449, Glyco_hydro_42, Beta-galactosidase. This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.	0
NC_012669.1\|WP_015883768.1\|3642925_3643900_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	2.06503e-89
NC_012669.1\|WP_015883772.1\|3648296_3649763_-\|glycoside-hydrolase-family-43-protein	gnl\|CDD\|350153	cd18832, GH43_GsAbnA-like, Glycosyl hydrolase family 43 protein such as Geobacillus stearothermophilus endo-alpha-1,5-L-arabinanase AbnA. This glycosyl hydrolase family 43 (GH43) subgroup includes mostly enzymes with alpha-L-arabinofuranosidase (ABF; EC 3.2.1.55) and endo-alpha-L-arabinanase (ABN; EC 3.2.1.99) activities. It includes Geobacillus stearothermophilus T-6 NCIMB 40222 AbnA, Bacillus subtilis subsp. subtilis str. 168 (Abn2;YxiA;J3A;BSU39330) (Arb43B), and Thermotoga petrophila RKU-1 (AbnA;TpABN;Tpet_0637). These are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. The GH43 ABN enzymes hydrolyze alpha-1,5-L-arabinofuranoside linkages while the ABF enzymes cleave arabinose side chains so that the combined actions of these two enzymes reduce arabinan to L-arabinose and/or arabinooligosaccharides. Many of these enzymes are different from other arabinases; they are organized into two different domains with a divalent metal cluster close to the catalytic residues to guarantee the correct protonation state of the catalytic residues and consequently the enzyme activity. These arabinan-degrading enzymes are important in the food industry for efficient production of L-arabinose from agricultural waste; L-arabinose is often used as a bioactive sweetener. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	2.44393e-149
NC_012669.1\|WP_015883773.1\|3650200_3651412_+\|alpha-hydroxy-acid-oxidizing-protein	gnl\|CDD\|376451	pfam01070, FMN_dh, FMN-dependent dehydrogenase.	1.40682e-155
NC_012669.1\|WP_083770072.1\|3657322_3657934_+\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	gnl\|CDD\|367243	pfam02909, TetR_C, Tetracyclin repressor, C-terminal all-alpha domain.	4.14062e-16
NC_012669.1\|WP_015883782.1\|3659477_3660419_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.32228e-66
NC_012669.1\|WP_015883764.1\|3639736_3641446_-\|hypothetical-protein	gnl\|CDD\|283837	pfam06259, Abhydrolase_8, Alpha/beta hydrolase. Members of this family are predicted to have an alpha/beta hydrolase fold. They contain a predicted Ser-His-Asp catalytic triad, in which the serine is likely to act as a nucleophile.	6.72237e-27
NC_012669.1\|WP_015883779.1\|3656744_3657167_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|211538	TIGR00026, Hypothetical_protein_Rv1261c/MT1299/Mb1292c., deazaflavin-dependent oxidoreductase, nitroreductase family. This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity].	1.16975e-08
NC_012669.1\|WP_015883770.1\|3645846_3646605_+\|aquaporin-family-protein	gnl\|CDD\|223653	COG0580, GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism].	6.00911e-63
NC_012669.1\|WP_015883771.1\|3646664_3648182_+\|glycerol-kinase-GlpK	gnl\|CDD\|198362	cd07789, FGGY_CsGK_like, Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases. This subgroup corresponds to a small group of bacterial glycerol kinases (GK) with similarity to Cellulomonas sp. glycerol kinase (CsGK). CsGK might exist as a dimer. Its monomer is composed of two large domains separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The regulation of the catalytic activity of this group has not yet been examined. Members in this subgroup belong to the FGGY family of carbohydrate kinases.	0
NC_012669.1\|WP_015883781.1\|3657940_3659392_-\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	2.35137e-45
NC_012669.1\|WP_015883767.1\|3642374_3642929_-\|amino-acid-N-acetyltransferase	gnl\|CDD\|236132	PRK07922, PRK07922, amino-acid N-acetyltransferase.	2.52282e-104
NC_012669.1\|WP_015883763.1\|3639292_3639721_-\|hypothetical-protein	gnl\|CDD\|374742	pfam16708, LppA, Lipoprotein confined to pathogenic Mycobacterium. This is a family of lipoproteins found only in pathogenic mycobacteria. These pathogenic lipoproteins may play a role in host-pathogen interactions. Lipoproteins localized to the cell-envelope of pathogenic bacteria are major determinants of virulence. The proteins are localized to the cell-surface via an N-terminal lipidation carried out by a transferase - pro-lipoprotein diacylglyceryl transferase Lgt - which attaches a diacylglyceride molecule to a sulfur atom from a crucial cysteine, and a consecutively acting lipoprotein signal peptidase LspA that cleaves the signal peptide just before the modified cysteine. When the peptidase is inactivated the pathogen has difficulty in replicating inside macrophages.	4.02879e-19
NC_012669.1\|WP_050761902.1\|3644063_3645761_+\|glycerol-3-phosphate-dehydrogenase/oxidase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	4.76485e-149
NC_012669.1\|WP_144016808.1\|3653997_3654690_+\|ATP-binding-protein	gnl\|CDD\|223645	COG0572, Udk, Uridine kinase [Nucleotide transport and metabolism].	3.12995e-18

>NC_012669.1|WP_015883772.1|3648296_3649763_-|glycoside-hydrolase-family-43-protein
MPSIDAPLTRRVMLGGTAAAAGALALGPAAAHAGGGRPGHPPTYVDATVHDPDVVRTGGRYYVFGSHAAAASTEDLFAWDQIAYDGVTPENPLFDDVTVELAEVLEWARTTTLWAPDVSRLPDGRFYYYYCACEGTSPRSGLGVAVADEVTGPYRDLGIILRSGQDDGTSEEPGEAYDPWVHPNVIDADVFADDDGTWWMVYGSFSGGILLLELDPATAKPVPGQGYGRHLMGGNHARIEGPAIMYHPGTRYYYLFVTFGGLDAAGGYNIRVSRARTPEGPWFDISGTDMSTVKADPDLPLFDDVTIAPHGTKIAGNVRFRTPDGAPGTGYVSPGGCSPWYDEESGDAFLAFHTRFPGTGEIHNVRVHRLAMTRSGWPVVLPFRYAGERLGGLGRHDVAGDYEVVTMAKPIGPEIAESRPVTLTRNGRVTGEHTGRWRLTGRSHVVLELDDVTYSGVAATQWDPDLEAWSVTFSAVSDAGTSVWGARR
>NC_012669.1|WP_015883771.1|3646664_3648182_+|glycerol-kinase-GlpK
MADYVLAIDQGTTSSRAIIFDHSGTIVATGQKEHEQIFPRAGWVEHDPEEIWTNVRDVVGQALGRASVRASNIAAIGITNQRETAVVWDRTTGKPVYNAIVWQDTRTQRIVEELGGSEGAEKYKARVGLPLATYFSGPKIKWILDNVDGAREAAERGDLLFGNTDTWVLWNMTGGVNGGVHVTDVTNASRTMLMDLDTLSWNPDIAADMGIPVSMLPEIRSSSEVYGKDREEGLLAGVPIAGILGDQQAATFGQACFEIGMAKNTYGTGNFMLMNTGTEQVASENGLLTTVCYKIGDQPQVYALEGSIAVTGSLVQWLRDNLKVISTAPEIENLALTVEDNGGAYFVPAFSGLFAPYWRADARGALVGLTRYVSLGHIARAALEATAFQSAEVLDAMKADSGVDLTELKVDGGMVANEVLMQFQADILGVDVVRPKVAETTALGAAYAAGIAVGFWNGEQDVIDNWAEDKRWTPQMDRGDRDRLYRNWKKAVTKTFDWVDDDVEN
>NC_012669.1|WP_015883770.1|3645846_3646605_+|aquaporin-family-protein
MDFSTIVIPEAAGTAMLVLLGCGVVANVVLPRTKGFDGGWLLVNFGWGLAVFAGVYVAFSTGAHINPAVTFGIWASGAEDFYVPPEGTEGQEAIPVTAGNGFAYIFAQMLGACIGAIVVYLAYKKHFDQDADPASKLAVFSTGPAIRSYGWNLVTEIVGTFVLVFVILHFAKTPSGLGPLAVALLVLGIGASLGGPTGYAINPARDLGPRIAHALLPIKGKGSSDWSYAWVPVLGPILGGVLGGLAAAGLTS
>NC_012669.1|WP_050761902.1|3644063_3645761_+|glycerol-3-phosphate-dehydrogenase/oxidase
MSSDEPLDVLVIGGGVTGAGIALDAVTRGLRTGIVEAQDWASGTSSRSSKLVHGGLRYLQMLDFHLVHEALTERDLLITQLAPHLVKPVSFLYPLEHRVWERAYVGAGVALYDTLASINGRRRALPLHRHVTRSGMERLFPDLRHDAAIGAVRYWDASVDDARLVITLIRTAASYGALAASRTQVVSLTKSGIGRVDGAIVADLETGEQHTIRATHVVNATGVWTEKTEALAGTEGGLRVLASKGIHIVVPRERIKGEVGLILQTEKSVLFVIPWSRYWVIGTTDTPWDLDPTHPVATAADIDYVLDHANAVLADPLTRDDIIGTWAGLRPLLQPGTKEGTSSAKVSREHTVASPAPGLTAIAGGKLTTYRVMAKDAVDFALGERARHLPSITERIPLIGAVGLQAMRRRSRALANEHGWTKEMVAHLLHRYGSGISDLLESIADQPDLARPLEHAPAYLRAEIAFAATHEQVLHLEDVLLHRTRLNYEVADRGRAALPEIAEVISPILGWDDERRAAEIAAYTARADAEDAAEKTWSDADGERVRLGAGDVAPMISLDAPSTTR
>NC_012669.1|WP_015883768.1|3642925_3643900_-|MarR-family-transcriptional-regulator
MDARDELMHEVASMYYLQDQTMEGIARRLGVSRSTVSRLIKSARAQGLVRISLRSPSSGTGTAARLRRTFGVRAHVVPIRASASQAARLDEVARVSARLLAEWFASGMTLGVAWGTTVAAVSRQLVPTPIHDATVVQLNGAANTHSSGLAYANDLVSSIARAFDATIHHFPVPAFFDYAATKEMMWRERSVRHVLQVQAQADVALFGVGALAGTVPSHVYSSGYLDDADRRALAGDRVVGDVCTVFLREDGSWEDIAINARATGPTPRELRRIPRRVCVVAGDSKVVPLLAALRAGAATDLVVDESTARALLRRSALPLGESPA
>NC_012669.1|WP_015883767.1|3642374_3642929_-|amino-acid-N-acetyltransferase
MSETEAPPSRTPGGAVTIRPALPRDARAIRDLVIPYAQARILLAKEMIGYYEAIQEFVVAEVDDGAGGRRVVGCGALHVMWSDLGEVRTLAVDGGFRSRGIGHLLLMELLARARALGLSRVFCLTFEVEFFTRHGFEAIEGAPVEPEVFAELVRSHDDGVAEFLDLAHVKQNTLGNTRMLLTLA
>NC_012669.1|WP_015883766.1|3641869_3642364_+|hypothetical-protein
MSDERAIPPDVALARSVRAATQALGVLAATTLVLGLVGAGALRMAGVEASASDPAGATLLPGVTMLGLGQLTALVGAGLAGWVLLYLLRDRVTDPTRAVRGLSRALGICAWVCVAACVVGIAAWAIVRPGAILPAVLGSLVSVQVAVVIGVLRTRVLPQATAAA
>NC_012669.1|WP_015883765.1|3641442_3641739_-|hypothetical-protein
MAGFDVDPPALRSAAARLGEAASAVGACDAAADLSGVPAAIADGLASSAARRLGQAWDARFRAWAEDADEHAASLTGAADAYEASDVGTGSALAGSPS
>NC_012669.1|WP_015883764.1|3639736_3641446_-|hypothetical-protein
MTVTLERLLSWDPTALGGAADALAGRRQTLLALQDEMDDGAPPPGWGGPAAGAARRTHGRLLDGLGDVVAEVAAVVTALDDAAESLGAARADLDEVLGLARGQGYDVDVSTGAVVDPESVSDAGAAGERSILAAEIEDRIEQALRTAAHADAELAGLLDRAARGALDGGPDLAASAQDGADAGRRDLLAPPEEARPGDAAGWWAGLTDGERTRVLAEHPEWVGNLDGIPGGVRDEANRSLIDDYRAELEAEAARLREDLADNVFGSLFTDADDRLAEVEGKLAGLDAVEATLARGGRQLLVLDPHDGDQLLAAVAVGDVDAADHVAVFTPGLDTTVGASLRGYDADMAALAQRAADEAERYGTGGTVATVAWLAYRAPQLDGSVLDVLGDERTSVASAQLAQRGGADLAEFLRGINASREHDPHLTALGHSYGSTTTGYALAEPTGVDDAAVFGSPGLGTSDAGYLAVPEGNLYRVEAKGDPVADLGRFGIDPSHLEGVRGLSAEEAALTGDDGCTLYSESTGHSGYLDASSTSQHNLAAVVGGAGDRLVYDDGRGAGDVLSWPVPGTY
>NC_012669.1|WP_015883763.1|3639292_3639721_-|hypothetical-protein
MTTPARPCLEDVIDAYARMRGEILAALETELGPAPWAPSATGGSLVRSGCGAGEDPGGERAQLGRWSYPGTYPDAQWPLAVDVVTAAAAAHGFDRVEATANRPRDVEIVAHDAWGGQIVFGMAANTILSLSTGCHPLRATRS
>NC_012669.1|WP_015883773.1|3650200_3651412_+|alpha-hydroxy-acid-oxidizing-protein
MVQRQLPKWQELAPLLRTKPFDPDPVRRRLAKALTIPELRRLALRRTPRSVFDYTDGAAEAEISLRRARAAFRSVEFQPSILHDVSDLSTATPMLGVDSALPFAFAPTGFTRMMQTQGESAVVRVAGRRGIPYALSTMGTTSIEDVAAASPEARKWFQLYVWRDRSAGEDLMARARAAGYEALVLTVDVPVAGARLRDARNGFSIPPALTLKTIADGATHPSWWIDLLTTPPLQFASLESWDGTIADLLDALFDPTMTMADLEWIRSQWDGPLVIKGIQTLDDARRVADAGADAIILSNHGGRQLDRAPVPLRLVPDTREAVGDRTEVWVDTGILSGADVVAAIALGAHATLVGRAYLYGLMAGGERGVERAVDILEAEVRRTMKLLGVNDIASLGPQHVRLP
>NC_012669.1|WP_015883774.1|3651431_3652370_-|hypothetical-protein
MRGDDENTGRQASARVWREVAPGTRELLEAGLGAADVRTLLQDVTAARAHATRPADVVARWQQDRFVRPATSDPRRVAALEARLWDLVPDDVAGVELSPVAPLGTAVAVGPVSERRIVTTTRLTEVVSDSTNVLAVEAAARRSGAPRGEQVHLAAIHRQLRAQDFGPGAASHFRLLALVSSARDTGSGRTEAGLLTRHVRVWQTMLGSTIPHRRPRIEFTVLGDDAVVAERWRDAVLPAVADGEVPVVEDASRERGRGYYTGVALRLVADDGAAEIGDGGLTTWTAQLLGDRKERCLVSCLATERLAELATD
>NC_012669.1|WP_043350272.1|3652713_3653529_+|hypothetical-protein
MARPQAADDTPRTTDRVRQVAVAASAVLAVAGSALGSGAFGGTQIQDAAGGALAADATVLAPGSGAFAIWTAVYLGLVAVAVVQLLPGRGTDEAHRATGWLLAASMLLNAAWILLAQAGQLVLTVAVIVVLVVVLGALAHLLVTRPARRRLDVVVLEATTGLYLGWASVATAADVAATLTDAGLTAEGAAEHVWGVAVVAQVAAVAVAACLATASRRLLAAAIGIAAAWGLGWIALGRLAAGPESPPVAIAATVAALVVLVVAVTAVVRRR
>NC_012669.1|WP_015883776.1|3653553_3653862_-|hypothetical-protein
MSENFFDKAKDAIGDAAEKAGDFFEEAKDKASDAFDDAKEKASDAFDDAKEKVSGMFDGADDAAAGAADTAQDAAAGAADTAQDAAAGAREAATDAKDDLTR
>NC_012669.1|WP_144016808.1|3653997_3654690_+|ATP-binding-protein
MPFPTTPEPASPADPPLFDLPSGARVPRRRVVLVTGPSGSGKTSLARRLGLPVVNLDDFYRDADHPGLPRRHGIVDWDSPATWDVEAAHAALLDACRSDRVDVPVYDIPTSQRTGTQTVDLDAAPLVLAEGIFAAELVDPLSRDGVLADAVHLTQGRLVTFWRRLARDVGESRKPIAALLRRGTHLLLAEPRMVRRWESQGTRPLAVEAAEHELRALAAHERTRHERHPT
>NC_012669.1|WP_015883778.1|3654670_3656716_+|beta-galactosidase
MSATPPEPAPAVGPAPATWPLGLPGIGYGGDYNPEQWPLEVRVEDVELMREAGVTIVSVGIFSWAMLEPREGDYDWAWLDDVLDRLATGGIRVALATATATPPPWLTTAHPEILPQRADGTVLHPGGRGAYAVTHPTYRAHVLRMTRAVAERYAAHPALALWHVDNELGCHVPRDYSPAAAAAFRAWLRRRYTDVDTLNAAWGTAFWSQRYSAFDEILPPLAAPTYANPTQQLDFARFSSDAWLDHYRAIVGVLREVTPHVPATTNLMMSGAVAMDYLRWGPELDVVANDHYTLAAEPLRHVDLALSADMTRGAARGAPWILMEHSTSAVNWQPRNRAKAPGEMRRNSLAHVARGADSVMFFQWRASAAGAEKYHSAMLPHAGTDTRVWREVVALGEDLRALAPVAGSRTQARAAVVMDYEAWWAVGLDSHPSVDVTHRDQLDAYYVALWERGITVDVVLPDADLAGYDLLVVPTLYLVGDDGAANLAAAAARGATVLVTYFSGIVDTSDHVRLGGYPGAFRDVLGVLTEEFAPLQEGETVTLDDGTRADVWTEHVRLDGAEAVRSFADGPAAGGPAVTRRAVGSGAAWYAATRLADDGVGRLVEALLAESGVAPAAAAPAGVEVVRRRHADDGASYLFAINHTGSDARVAASGTDLLTGTAWDGETPVPAGGVVVLAEPA
>NC_012669.1|WP_015883779.1|3656744_3657167_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MPMPGWWGHINKRIFNPRALASGKWPVLTHVGRTSGTTYRTPLDAYPVDGGYLFVLVYGSGSDWVRNVLASGRARLRVDGADVDLDAPRLVGRVEAFRDLPSRAHPPGLLRVTEFLRMDAVAGGTADLPGGQDRGRSGST
>NC_012669.1|WP_083770072.1|3657322_3657934_+|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein
MLQAAIRVADRGGVQAITMRKVAQELGVEAMSLYHHVPGKEALLDGVVDTVFAAIDLPATGGDWRDAIRARAASARTVLTAHSWALGLLDSRRDPGPATLRHHDAALGVLRGAGFDLPMAAHAISLIDSYVNGWVLAEANLPVMTPGDVEDVAGGILEHLPADELPHLTEMIVDHALRPGYDHTAEFGWGLDLVLDALEERRT
>NC_012669.1|WP_015883781.1|3657940_3659392_-|APC-family-permease
MAESGGTTTTAQGPDGPSLKRVMGPGLLLLFIVGDILGTGVYALTGDVAAEVGGAAWLPFVVAFAVALVTAFSYLELVTKYPHAAGAALYTHRAFGIHVLTFMVCFTVMSSGITSASTASRAFAANAIVGFTSVEEPSTSTIVWVALGFMALVALVNLRGVSESVKANVVLTCIELSGLLLVILVGIWAFFGTTADFSRVVAFETPDDKSAFLAVTAATTLAFFAMVGFEDAVNMAEETKEPTRIFPRIMFTGLTITGLIYVLVAISAVALVPVGELAASETPLLEVVRAGAPGLPVDQIFPFISMFAVANSALINMLMASRLLYGMARQRVLPPILGKVHERRRTPWTAILFTTALAFGLIVYVSFADSEATAVLGGTTALLLLGVFTIVNIAVLVLRRRTVDHAHFRAPTAVPVIGAMACAYFVGPWTGRDPAQYGVAGVLLVLGLVLWGITMLINRALGVRTPRPDEEDLDQISTRGPVN
>NC_012669.1|WP_015883782.1|3659477_3660419_-|carbohydrate-ABC-transporter-permease
MTATSGTAASSAPATTRTATPTRQRRHVGPEHGSTSPARTIIVTGILVVVALYFLVPVYWVFVAATKTTEDLFATNGFWFAPTFNLWSNIAQVFTYDGGIFVRWFANSVLYAGVGGLIATYFAAAGGYALAKYSFRGRELVFGLILGGVLVPGTATALPLFLLFSQLGLANTYASVLIPSLVSPFGLFLCRIYATATVPDSIVEAARIDGAGELRIFHQLGLRALTPALVTVFLFQLVGIWNNYFLPLVMLADQSLYPITLGLNNWRAQVDRLPEFYELTTGGVLVSVVPLAIAMIVLQRYWRGGLTAGAVKE

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Crispr_ID: NC_012669_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012669_10

4451362-4451466

Orphan

Consensus_repeat	Method
AGACCCGGCGTCACCGCCACCGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012669_10

>merge|NC_012669|10|4451362-4451466|CRISPRCasFinder
AGACCCGGCGTCACCGCCACCGTGCGGTTCGTCCCCCGAACCGGCCTCTCCGGGGGAACAACCACACGGCGACCCAGGCAGAGACCCGGCGTCACCGCCACCGCG

>NC_012669|10|9|4451362-4451466|CRISPRCasFinder
AGACCCGGCGTCACCGCCACCGTG	CGGTTCGTCCCCCGAACCGGCCTCTCCGGGGGAACAACCACACGGCGACCCAGGCAG
AGACCCGGCGTCACCGCCACCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012669.1\|WP_015884497.1\|4447630_4448704_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227596
NC_012669.1\|WP_015884492.1\|4439251_4440262_+\|porphobilinogen-synthase	unknown	unknown	gnl\|CDD\|236450
NC_012669.1\|WP_015884495.1\|4443317_4445081_-\|DUF4091-domain-containing-protein	unknown	unknown	gnl\|CDD\|379121
NC_012669.1\|WP_144017005.1\|4450164_4451088_-\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|379128
NC_012669.1\|WP_015884502.1\|4451546_4452347_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912
NC_012669.1\|WP_015884506.1\|4454441_4455284_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_012669.1\|WP_015884504.1\|4453302_4453605_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|316153
NC_012669.1\|WP_015884496.1\|4445297_4447631_-\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NC_012669.1\|WP_043347642.1\|4456447_4457353_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_012669.1\|WP_015884499.1\|4449081_4449363_+\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376835
NC_012669.1\|WP_015884493.1\|4440407_4441883_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607
NC_012669.1\|WP_015884509.1\|4457365_4457956_-\|HdeD-family-acid-resistance-protein	unknown	unknown	gnl\|CDD\|225786
NC_012669.1\|WP_043347636.1\|4448700_4448913_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328
NC_012669.1\|WP_015884505.1\|4453601_4454264_-\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_015884511.1\|4460962_4462177_+\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|223704
NC_012669.1\|WP_015884500.1\|4449458_4449857_+\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328
NC_012669.1\|WP_043347629.1\|4442170_4443325_+\|AlkZ-family-DNA-glycosylase	unknown	unknown	gnl\|CDD\|377630
NC_012669.1\|WP_015884507.1\|4455290_4456277_-\|2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|235821
NC_012669.1\|WP_015884503.1\|4452343_4453306_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_012669.1\|WP_015884510.1\|4458108_4460859_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|377103

Protein	Function_ID	Function_description	E-value
NC_012669.1\|WP_015884497.1\|4447630_4448704_-\|hypothetical-protein	gnl\|CDD\|227596	COG5271, MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only].	0.000264916
NC_012669.1\|WP_015884492.1\|4439251_4440262_+\|porphobilinogen-synthase	gnl\|CDD\|236450	PRK09283, PRK09283, porphobilinogen synthase.	0
NC_012669.1\|WP_015884495.1\|4443317_4445081_-\|DUF4091-domain-containing-protein	gnl\|CDD\|379121	pfam13320, DUF4091, Domain of unknown function (DUF4091). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length. There is a single completely conserved residue G that may be functionally important.	7.48818e-24
NC_012669.1\|WP_144017005.1\|4450164_4451088_-\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	gnl\|CDD\|379128	pfam13338, AbiEi_4, Transcriptional regulator, AbiEi antitoxin. AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	0.00040823
NC_012669.1\|WP_015884502.1\|4451546_4452347_-\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	1.95519e-07
NC_012669.1\|WP_015884506.1\|4454441_4455284_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	2.12334e-08
NC_012669.1\|WP_015884504.1\|4453302_4453605_-\|transcriptional-regulator	gnl\|CDD\|316153	pfam13601, HTH_34, Winged helix DNA-binding domain.	1.84571e-17
NC_012669.1\|WP_015884496.1\|4445297_4447631_-\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_012669.1\|WP_043347642.1\|4456447_4457353_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	7.30497e-12
NC_012669.1\|WP_015884499.1\|4449081_4449363_+\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|376835	pfam02583, Trns_repr_metal, Metal-sensitive transcriptional repressor. This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression.	5.32879e-31
NC_012669.1\|WP_015884493.1\|4440407_4441883_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	1.4532e-146
NC_012669.1\|WP_015884509.1\|4457365_4457956_-\|HdeD-family-acid-resistance-protein	gnl\|CDD\|225786	COG3247, HdeD, Uncharacterized conserved protein [Function unknown].	5.40644e-21
NC_012669.1\|WP_043347636.1\|4448700_4448913_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	4.49066e-12
NC_012669.1\|WP_015884511.1\|4460962_4462177_+\|serine/threonine-protein-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	6.99346e-67
NC_012669.1\|WP_015884500.1\|4449458_4449857_+\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	9.36697e-15
NC_012669.1\|WP_043347629.1\|4442170_4443325_+\|AlkZ-family-DNA-glycosylase	gnl\|CDD\|377630	pfam06224, HTH_42, Winged helix DNA-binding domain. This family contains two copies of a winged helix domain.	4.7629e-31
NC_012669.1\|WP_015884507.1\|4455290_4456277_-\|2-dehydropantoate-2-reductase	gnl\|CDD\|235821	PRK06522, PRK06522, 2-dehydropantoate 2-reductase; Reviewed.	3.10518e-47
NC_012669.1\|WP_015884503.1\|4452343_4453306_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.39425e-84
NC_012669.1\|WP_015884510.1\|4458108_4460859_+\|flippase-like-domain-containing-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	1.00221e-22

>NC_012669.1|WP_144017005.1|4450164_4451088_-|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein
MLDAARLQFGLVTTAQCEAAGITRNARAVRVARGDWVRPTRGVYDLAPGAAVDMDPGWRRRRGAVLGLLAYGPEAVAVGTSALALHGLWGLPLRSLPQVALPSGDSRLSRDGIRVRRFTVPRVTRTGEGYAVAPVGLALAQAIPELDRDHAVALLDSALNLERIDGADIAKVRDVVRHRRGASRAAGWWDLVDARSESTYETFARLECHDAGIAPDELQVPMVLPDGRRARGDLGWQIDPRTWLLAEIEGEDAHAARRARRKDQRRQNGLTISGEATVLRYDPADVWTGVIPAEVKEFLRSRRRRGA
>NC_012669.1|WP_015884500.1|4449458_4449857_+|heavy-metal-associated-domain-containing-protein
MPTTLTTLDVTGMTCGHCVSAVTNELETVDGVQSVTVELHAGGTSEVTVLSHAPLAEDALRAAIDEAGYDVTGVRAHGEAEEWAEEGHAQQTADDAAAGSAGVPASGGGCGCGCGTASDAGPNVVEIGKRPS
>NC_012669.1|WP_015884499.1|4449081_4449363_+|metal-sensitive-transcriptional-regulator
MPGYSGTKADYAKRMRRIEGQVRGIARMIDEDEYCIDVLTQVSAVTKALQAVSLGLLEDHLGHCVVDAARAGDEEGDAKVREAADAIARLVRS
>NC_012669.1|WP_043347636.1|4448700_4448913_-|heavy-metal-associated-domain-containing-protein
MSTQTYQVTGMTCGHCESAVHGEVATLPGVTRVEVSAVTGRLVVVAEAILADDAVLAAVDEAGYSAERAE
>NC_012669.1|WP_015884497.1|4447630_4448704_-|hypothetical-protein
MRTPTRLGLFGAGLAAIFAATFAVGSAVIPDDAAAGWADTDETREAGDDMSHEDDMTSTEDPAAPAPDDEASHEDGAAEAGGTHDDGASGGHGEPVRGLSLEQDGYVLSEVTAPGGVGEAGDLSFRVDGGDGHPLTAFAESHEKRLHLIVVRSDGSEFRHVHPEMSDDGTWTIPWTWDEPGTYRVFADFVPADGAADDPPDVTLTRSVDVEGAATPSPATTVRTTTSVDGFDVTLDGELLAGADSTLTATITRAGEDVTTLEPYLGAFGHLVALRQGDLAYLHVHPEGAEPAAGDVSGPEVVFATQAPTPGRYLLYLDFQVDGEVHTAAFVLDAAADHHAPESSDDGNEDSTDGGEH
>NC_012669.1|WP_015884496.1|4445297_4447631_-|copper-translocating-P-type-ATPase
MAAASFQSAPGVIELEVGGMTCASCAMRIEKKLNRLDGVEATVNYATEKATVTAPEGYDPQLLIAEVEKTGYTAQVPVPPSSATADDDDADRPDPELTSLRQRLVGAVVLSVPVIVLAMVPAWQFTYWQWASLALAAPVALWSAWPFHRAAWLNLRHGAATMDTLVSVGVLAAFGWSLYALFLGTAGEPGMTHGFELTVGRSDGAANIYLEVASGVTMFVLAGRYFEKRSKRQAGAALRALLQLGAQEVAVLRGGAETRIPIDQLVVGDEFVVRPGEKIATDGVVVAGASAVDESMLTGESVPIEVTEGDAVVGATVNAGGRLVVRATRVGSDTQLAQMARLVEAAQSGKAEVQRLADRISGVFVPIVVAIAVGTLGVWLGGGFPATAAFTAAVAVLIIACPCALGLATPTALLVGTGRGAQLGILIKGPEVLESTRRVDTIVLDKTGTVTTGRMTLTAVVADDGVDRTELLRLAGGLEHASEHPIARAIASAAADEVGELPTPDGFTNLGGLGVRGTVEGRAVVVGRASLVAGSGRATGGAEGTSDDGGTTPEADLPPALAAAQASAERDGRTAVVVGWDGAARGVLVVADAVKPTSAEAVRQFRILGLTPVLLTGDHRAVAEQVAAEVGIERVIAEVLPEGKVEAVAALQAEGRVVAMVGDGVNDAAALAQADLGLAMGTGTDVAIEAADLTLVRGDLRAAADAIRLSRRTLGTIKGNLFWAFAYNTAAIPLAALGLLSPMLAGAAMAFSSVFVVGNSLRLRSFASRATDGAGAR
>NC_012669.1|WP_015884495.1|4443317_4445081_-|DUF4091-domain-containing-protein
MRRATTDARPYPRPDWTFVLADSLEKVFPDVAPRPMSRPELSGFLGEALAVQLAFLPPAAHSPAAIGPVTVRARGELAHLARLSTVELVPCQLPAFDGHDDGYLRDTPGLYPDLLRPIEQADAGDARAGAPGAVDAAGLAGTLHPRLGYWQAVWVDLQVDDPALAGRRTLTLEMSDADGKPLHTAELAVVVHPVALPALDIVNMHWLHADSLLTYYGVDAFSEEHWRLLEEYVASAAAMRANSLLTPTWTPPLDTAIGGTRPPVQLVGISDDDGGAYAFDFSRLGRWLALCKRHGITTLEVAHLFTQWGATATPAIYVETPSGTEQRFGWHVPATDPSYRELLASLLPALRGYLAEHWSGDVIFHVSDEPRPEMLSDYREARAVVDDLLDGATIADALSDLAFAQDGVVDTPIVATNHVQPFLDAGMTPWVYYCVSQNRDVANRFIALPSVRNRVLGRQLFAFSAPGFLHWGFNFWFAQHSTRPIDPHADTSAGGAFPSGDPFIVYPGPNGEAWPSLRHRVFAQAMDDHRALQLLRTLTDQATARSYVDEGGALAYDAFTYDPEHYLETRRAVDARILAELAGARAT
>NC_012669.1|WP_043347629.1|4442170_4443325_+|AlkZ-family-DNA-glycosylase
MVTTTRRQVLAFRLRQQHLARRLGAARMGEATATCGVRNSPAGSAPVALLARVNGVSEDRVSAALSGKHLVEVEDPRLVPALVRPEDLAVFTVGGIDTDDASLRVKFGRGAAKALAAAGIRPIEALNRVVEAAHAELAGGVRSTGELSAAMTARLPGPMSLWCQRCGSRHIHESLFRLPSAAGISCLAPRSGRQVRYVRVDKWLGTDVPEVGSPAARDAGRELLRRFLHCYGPATPGEFADWTRTAAGAARHRFAEIADDLQDVSWDGHTGSVLRDDVDELRDARTPSGVRLLPPNDPYLLAPDRAALIPDPSSRTVLWPALSAPGAVVIDGEIVATWRSQKKGTALRVQISPFDRPIATAAALIEQEAHLLADLRGCQRVEVT
>NC_012669.1|WP_015884493.1|4440407_4441883_+|glutamate-1-semialdehyde-2,1-aminomutase
MSAASTMDEVFDRARAAIPGGVSSPVRAFGSVGGTPRFIASASGPHVTDVDGREYVDLVGSWGPAILGHAHPEVVAAVQEAASRGLSFGAPTLGEVELAEEIRRRVPPAERVRLVSTGTEATMTAIRLARGVTGRDLVVKFAGCYHGHVDALLAAAGSGLATLALPGSAGVTPATAAETLVLPYGDVPSLEAAFAAHDGRIAAVITEAAPANMGVVEPGTFNAEIRRVTAAHGALMICDEVLTGFRTGPSGWWGVENDVADGAAALAAAADQGSGARARTPATSSYSPVSDLAADVRARRDDPLAADAGPSTTAVWTPDLFTFGKVVGGGMPVAAIGGPAAIMDALAPLGPVYQAGTLSGNPVAVAAGLATLRLADDAVYARLADTSRAVRTGLTEALDAVGLAHAVSSAASLFSVAFRDERPRGWDDVQAQETFRYPAFFHAMLDAGVALPPSVFEAWFVSAAHDDAAVGRVLDALPGAARAAAAVVAPR
>NC_012669.1|WP_015884492.1|4439251_4440262_+|porphobilinogen-synthase
MTVLPPGSPRPRRLRATPALRRLTAEHRLDARDLVLPLFLREGASEAVPIASMPGVVQHSRDSLRAEVVRAAEAGIGGVMLFGVPTTRDAEGSGADDPDGVLNTGIRDAIAEVGDAVVVMADLCLDEFTDHGHCGVLDGAGRVDNDATLERYAAMALAQADGGAHVLGLSGMMDGQVGHVRAALDDAGRADTALLAYSAKYASAFYGPFRDAVESRLVGDRRAYQLDPANRREGLRETLLDLAEGADAVMVKPALAYLDVLADVASASDVPVWAYQVSGEYAMVEAAAANGWIDRERAVRETLLSIVRAGADAVLTYWALDVAGWLRADGGAGGAR
>NC_012669.1|WP_015884502.1|4451546_4452347_-|ABC-transporter-permease
MTAATASVPVRPARPPRSALRLGLLHAKYQFLEAIRIPIAVIGTMMFPTLAMVFFVVPNQAVAQNPVFATAAVAQLGMFSIMATCLFTYGTGVAEDRDRPFDPYMRTLPAGASAQMIGRVANGLIFAALGLLPLVLAGWILTAATLSWSRLLVSVLTILALAIPFTMLGLGIGYSLPSKAAIAVVQVVLFPLAFAGGLFLPPQMFPGWLDAFSQALPSRAGRDLLVQVTSGEPAYGLALPVLLGWTVLFAVFVVWAYRRDEGRRFR
>NC_012669.1|WP_015884503.1|4452343_4453306_-|ABC-transporter-ATP-binding-protein
MTAVISLDHATRRYGDVVALDDVSLEVPAGELVGLLGPNGAGKSTLLNLVNGLRPTTSGTVRIFGADPRVPASRIQLGTTPQETGLPPTLRVGEVVDFVGGHYPDPMSRDELLSRFGLADLAQRQTGGLSGGQKRRLAVALSIVGRPRLVLLDEPTTGLDVEARRLLWDAVREYHADGATIVVTSHYLEEIEALAQRVVVIGHGHVLADDDLATIVGRVSARHVRLRLAGDARAVVDALPGVVDATADGDRWTILTTDSDAVIRALVTQGVTFSGLEVRGASLEEAFLAMTASDDDGDASSGAHVAPSSSPSDQTQGALR
>NC_012669.1|WP_015884504.1|4453302_4453605_-|transcriptional-regulator
MNDGLDPVIHAPARLRLVVVLAQLGPEDRISFPRVQKELDMTAGNLSTHVRKLEDAGYVAVTKTHERRTPVTYLALTSEGRVALERYRAAVTSLLKGAVS
>NC_012669.1|WP_015884505.1|4453601_4454264_-|hypothetical-protein
MTDPREGGPSSEVEPSEGLDAAESLRILGADAARVRVRIEPDGRVLFLVWGIAWTIGYLTLWVASRDDGVPPGWAFVVFTAALVIAIVLTAVHIARRTMGVRGASAVSGAMYGWAWSLSFVMLGVLLRTMGEHGASEELIGLMANGISCLIVGALYMAGAAIWRSWSQFALGVWIVLVGAVATLSGVPTAFLIMATAGGGGMLVGALLTRLSLRRATASR
>NC_012669.1|WP_015884506.1|4454441_4455284_+|CPBP-family-intramembrane-metalloprotease
MATSIADSPWRTFWNRGGVWRAVLLAVVYLAIYLAAGLLAGTLFRDQLGDDDVFATPMSVFAGLTFALIIGAIVLTAFLASVRWFGPVFGPQPIGGRAWMWVIPVLVAVPIVLRLAGIDYESYASGVVLVTLLSGLLIGFCEEVLCRGIVVKMLRDGGRSEWTVMAVSSLIFALLHSANLLAGMAPATVALTIVYTFGFGACMYLTLRVTGRLIWPIVLHGLFDPTLFLATGGIDAESGEQTSSLLALAAPFNFVFIAAGLVALLVVRGRVQRVPEPQAA
>NC_012669.1|WP_015884507.1|4455290_4456277_-|2-dehydropantoate-2-reductase
MRYVIIGAGAVGATIGASLHEAGRDVVLVARGEHLRVLREDGLTFATPSSTRVLPIPAAGGPDDLVLRPDDVLVLATKSQDTAGALAAWAPATVDGGTAGERLTVVCAQNGVDNERQVLRRFGHVVAVTVWLPATHLRPGVVVAPGDPAPGVLTLGRYPSGVDATVELIGTDLAAGGFVAPVRDDVMRWKYAKLLGNLGNAADALFGRDDDAASLVRRARQEGEAALEAAGIPWTSDEEQSAMRSAFGVGTVPGFERGGSSTWQSLARGTGSVEVDYLNGEIVLLGRTHGVPTPVNAALQARAAVAAAAGAAPGSGRAAELLAALAAQ
>NC_012669.1|WP_043347642.1|4456447_4457353_+|CPBP-family-intramembrane-metalloprotease
MTDAEGAPPGAPGPADARASAPTPTDRPAAPTPAPTDRPGAPAPSPAATRRRLTWEIWLVLGVSLLGSATLAILNLVDRLTIDIPLGDQSATLNPPANERPWLDLLYQLRRIAFLALPAFLALYLLSANGRSAARRIGLDLTRPWKDLRDGVVLAALVGIPGLGVYAIGRALGITVEVRASGLDGIWWTVPVLILAALANALVEEVVVVGYLAERLRELRWQVPAILVVSALLRGSYHLYQGPGMAIGNVAMGVLFAWYYLSPRWGHRVLPLVIAHTLIDVVAFVGYQLLPEAWLTALGLA
>NC_012669.1|WP_015884509.1|4457365_4457956_-|HdeD-family-acid-resistance-protein
MSESPGAPAPLFSQLAGQVWYYPVIRGVLAIILGILALVWPGATVLTLVLLLGAFWVVDGIVELVDGIRWRGLPGAGWRIFFGIVSIIAGLVLLFRPGMSLDVIIIVGGIWAILGGIFIVVAAFQARPLPGWGWTLFTGIVIAILGILLLVQPGITAAALVLTLGIWAIVVGLVLVILGFQIRSAGKRAANDARTA
>NC_012669.1|WP_015884510.1|4458108_4460859_+|flippase-like-domain-containing-protein
MSEADAPGTTVPQAPAPSVPPPTRTVEIIDVPAHRLRRPGDLVAMILALLGVVLVLLLAVYAHRTTEGVTEDIENALPDFLERLLDIPLNLLEGLVTFLLPLLVIVERLIRRQVRVVLEALAAAVVAALLTGAGAWLLRSFAPDALVDGLAIASGTALSPAVAAIAALLTTIGSRDRRRAVGWSWNLLWIVLVLQVLMGAMSLPGALVSVLLGRALGLAARYLWGVRGERAYGRDLVTAIRRAGLDPLRIQRIADPEDLAEATAELVTTNSPIGYVTEHPDALPARAERRAEIREERGADDDGAPPTSSPAFMAATSEQADDGEPAPFSSPTPVVTLDDESAPADAGPPAPIRLRVSDPATVALAREGENRVYAVVDADGTRWDVVVLDGDRQVVGTLAAFWSTIRLKGLEQRAVVSLRAAAARAALMTYAAAAAGVRAPRLQGIADEEDSVLLVGEHVSSATTLSAMQPDDITDELLDGAWEQLRVAHDAGLAHRAITGDAILVASGRDVWLTAWENGEIAASELARRLDLAQMLALLALTVGPERAMASASRSLTEEQLVAIAPILQPVALPPATRAAARRDKQVLARVQNLLVDLIPTAQTEPMQLARFSARTVVTVTVAVIAGFILLTTLNFDQIIAAVREANPVWMVVAFLLGLLTYLGSAMSLVAFSPEKLPLWRTTLVQVAASVITLVAPAGIGPAALNLRYLQKNRIATPMALATVALVQVSQFVTTVLLLLVIALVTGSSGALDSLPSGAVLLVVALVLVAASTAFAFPAVRRWVLARLVPMLRQVWPRVVWVVGQPGRLAMGIGGNLIMTIGYLAAFQAALEAFAQSVPLTSLAIIYLVGTAAGSAIPTPGGVGTVELALTSGLRTAGVPTAVAASSAVLFRVLTFWGRVPLGWLAMRYLQKRDAI
>NC_012669.1|WP_015884511.1|4460962_4462177_+|serine/threonine-protein-phosphatase
MTVSFRFAAITDLGTVRTNNEDTALATPHLLALADGMGGHAAGEVASAVAMRAVLDLVRDPPAGDLAGAVVGAAQRARGALHAMSRADPELEGMGTTLVVLAAGGDGLTLAHIGDSRLYRMRDGQLTQLTVDHTHVQRLVDNGQLTPAGARTHPYRSMILRSLDDTSDDEPDIAVPDIAPGDRLLLCSDGLSDYVADEHLEALLADGDVEHAAQALVDVALTMHSRDNVTVVVADVLDDDAPDAPDGVAVGASLDAAVLSGPARRALQAVFDDVEPDADTVPRPGEAAAASAAAPASAEGDEDEPDLAEELLGTSDEAVDDEDEVHEDPPGDVDDEPADPAPADVGHVASSESGRSSDVVAGTSDPVSSAAPDSVPAGRRAWPWVVGAVAVLAAAVAAWWVWLR

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Crispr_ID: NC_012669_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012669_9

4449893-4450125

Orphan

Consensus_repeat	Method
GGGGAACAACCACACGGTGACC	PILER-CR

3 spacers

The CRISPR arrays of NC_012669_9

>merge|NC_012669|9|4449893-4450125|PILER-CR
GGGGAACACCCACACGGTGACCAGCCAGAGGCCCGAGCACCGTGTCGTTGTTCCCCCGAACGACCCCTTCCCGGGAACAACCACACGGTGACCCCGGCGTCACGGCGACCGTGTGGTTCGTCCCGCGAATAGCCACCACAGGGGAACACCCACACGGTGACCAGCCAGAGGCCCGAGTACCGTGTCGTTCGTCCCCCGAACGACCTCTTCGGGGGAACAACCACACGGTGACC

>NC_012669|9|1|4449893-4450125|PILER-CR
GGGGAACACCCACACGGTGACC	AGCCAGAGGCCCGAGCACCGTGTCGTTGTTCCCCCGAACGACCCCTTCC
CGGGAACAACCACACGGTGACC	CCGGCGTCACGGCGACCGTGTGGTTCGTCCCGCGAATAGCCACCACA
GGGGAACACCCACACGGTGACC	AGCCAGAGGCCCGAGTACCGTGTCGTTCGTCCCCCGAACGACCTCTTCG
GGGGAACAACCACACGGTGACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012669.1\|WP_015884497.1\|4447630_4448704_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227596
NC_012669.1\|WP_015884492.1\|4439251_4440262_+\|porphobilinogen-synthase	unknown	unknown	gnl\|CDD\|236450
NC_012669.1\|WP_015884495.1\|4443317_4445081_-\|DUF4091-domain-containing-protein	unknown	unknown	gnl\|CDD\|379121
NC_012669.1\|WP_144017005.1\|4450164_4451088_-\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|379128
NC_012669.1\|WP_015884502.1\|4451546_4452347_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912
NC_012669.1\|WP_015884506.1\|4454441_4455284_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_012669.1\|WP_015884504.1\|4453302_4453605_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|316153
NC_012669.1\|WP_015884496.1\|4445297_4447631_-\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NC_012669.1\|WP_043347642.1\|4456447_4457353_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_012669.1\|WP_015884499.1\|4449081_4449363_+\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376835
NC_012669.1\|WP_015884493.1\|4440407_4441883_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607
NC_012669.1\|WP_015884505.1\|4453601_4454264_-\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_043347636.1\|4448700_4448913_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328
NC_012669.1\|WP_015884491.1\|4437887_4439255_+\|uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|376850
NC_012669.1\|WP_015884500.1\|4449458_4449857_+\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328
NC_012669.1\|WP_043347629.1\|4442170_4443325_+\|AlkZ-family-DNA-glycosylase	unknown	unknown	gnl\|CDD\|377630
NC_012669.1\|WP_015884509.1\|4457365_4457956_-\|HdeD-family-acid-resistance-protein	unknown	unknown	gnl\|CDD\|225786
NC_012669.1\|WP_015884507.1\|4455290_4456277_-\|2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|235821
NC_012669.1\|WP_015884503.1\|4452343_4453306_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_012669.1\|WP_015884510.1\|4458108_4460859_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|377103

Protein	Function_ID	Function_description	E-value
NC_012669.1\|WP_015884497.1\|4447630_4448704_-\|hypothetical-protein	gnl\|CDD\|227596	COG5271, MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only].	0.000264916
NC_012669.1\|WP_015884492.1\|4439251_4440262_+\|porphobilinogen-synthase	gnl\|CDD\|236450	PRK09283, PRK09283, porphobilinogen synthase.	0
NC_012669.1\|WP_015884495.1\|4443317_4445081_-\|DUF4091-domain-containing-protein	gnl\|CDD\|379121	pfam13320, DUF4091, Domain of unknown function (DUF4091). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length. There is a single completely conserved residue G that may be functionally important.	7.48818e-24
NC_012669.1\|WP_144017005.1\|4450164_4451088_-\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	gnl\|CDD\|379128	pfam13338, AbiEi_4, Transcriptional regulator, AbiEi antitoxin. AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	0.00040823
NC_012669.1\|WP_015884502.1\|4451546_4452347_-\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	1.95519e-07
NC_012669.1\|WP_015884506.1\|4454441_4455284_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	2.12334e-08
NC_012669.1\|WP_015884504.1\|4453302_4453605_-\|transcriptional-regulator	gnl\|CDD\|316153	pfam13601, HTH_34, Winged helix DNA-binding domain.	1.84571e-17
NC_012669.1\|WP_015884496.1\|4445297_4447631_-\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_012669.1\|WP_043347642.1\|4456447_4457353_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	7.30497e-12
NC_012669.1\|WP_015884499.1\|4449081_4449363_+\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|376835	pfam02583, Trns_repr_metal, Metal-sensitive transcriptional repressor. This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression.	5.32879e-31
NC_012669.1\|WP_015884493.1\|4440407_4441883_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	1.4532e-146
NC_012669.1\|WP_015884509.1\|4457365_4457956_-\|HdeD-family-acid-resistance-protein	gnl\|CDD\|225786	COG3247, HdeD, Uncharacterized conserved protein [Function unknown].	5.40644e-21
NC_012669.1\|WP_043347636.1\|4448700_4448913_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	4.49066e-12
NC_012669.1\|WP_015884491.1\|4437887_4439255_+\|uroporphyrinogen-III-synthase	gnl\|CDD\|376850	pfam02602, HEM4, Uroporphyrinogen-III synthase HemD. This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea. This enzyme catalyzes the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O. Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis, such as HemD with pfam00590, however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease.	1.11635e-30
NC_012669.1\|WP_015884500.1\|4449458_4449857_+\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	9.36697e-15
NC_012669.1\|WP_043347629.1\|4442170_4443325_+\|AlkZ-family-DNA-glycosylase	gnl\|CDD\|377630	pfam06224, HTH_42, Winged helix DNA-binding domain. This family contains two copies of a winged helix domain.	4.7629e-31
NC_012669.1\|WP_015884507.1\|4455290_4456277_-\|2-dehydropantoate-2-reductase	gnl\|CDD\|235821	PRK06522, PRK06522, 2-dehydropantoate 2-reductase; Reviewed.	3.10518e-47
NC_012669.1\|WP_015884503.1\|4452343_4453306_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.39425e-84
NC_012669.1\|WP_015884510.1\|4458108_4460859_+\|flippase-like-domain-containing-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	1.00221e-22

>NC_012669.1|WP_015884500.1|4449458_4449857_+|heavy-metal-associated-domain-containing-protein
MPTTLTTLDVTGMTCGHCVSAVTNELETVDGVQSVTVELHAGGTSEVTVLSHAPLAEDALRAAIDEAGYDVTGVRAHGEAEEWAEEGHAQQTADDAAAGSAGVPASGGGCGCGCGTASDAGPNVVEIGKRPS
>NC_012669.1|WP_015884499.1|4449081_4449363_+|metal-sensitive-transcriptional-regulator
MPGYSGTKADYAKRMRRIEGQVRGIARMIDEDEYCIDVLTQVSAVTKALQAVSLGLLEDHLGHCVVDAARAGDEEGDAKVREAADAIARLVRS
>NC_012669.1|WP_043347636.1|4448700_4448913_-|heavy-metal-associated-domain-containing-protein
MSTQTYQVTGMTCGHCESAVHGEVATLPGVTRVEVSAVTGRLVVVAEAILADDAVLAAVDEAGYSAERAE
>NC_012669.1|WP_015884497.1|4447630_4448704_-|hypothetical-protein
MRTPTRLGLFGAGLAAIFAATFAVGSAVIPDDAAAGWADTDETREAGDDMSHEDDMTSTEDPAAPAPDDEASHEDGAAEAGGTHDDGASGGHGEPVRGLSLEQDGYVLSEVTAPGGVGEAGDLSFRVDGGDGHPLTAFAESHEKRLHLIVVRSDGSEFRHVHPEMSDDGTWTIPWTWDEPGTYRVFADFVPADGAADDPPDVTLTRSVDVEGAATPSPATTVRTTTSVDGFDVTLDGELLAGADSTLTATITRAGEDVTTLEPYLGAFGHLVALRQGDLAYLHVHPEGAEPAAGDVSGPEVVFATQAPTPGRYLLYLDFQVDGEVHTAAFVLDAAADHHAPESSDDGNEDSTDGGEH
>NC_012669.1|WP_015884496.1|4445297_4447631_-|copper-translocating-P-type-ATPase
MAAASFQSAPGVIELEVGGMTCASCAMRIEKKLNRLDGVEATVNYATEKATVTAPEGYDPQLLIAEVEKTGYTAQVPVPPSSATADDDDADRPDPELTSLRQRLVGAVVLSVPVIVLAMVPAWQFTYWQWASLALAAPVALWSAWPFHRAAWLNLRHGAATMDTLVSVGVLAAFGWSLYALFLGTAGEPGMTHGFELTVGRSDGAANIYLEVASGVTMFVLAGRYFEKRSKRQAGAALRALLQLGAQEVAVLRGGAETRIPIDQLVVGDEFVVRPGEKIATDGVVVAGASAVDESMLTGESVPIEVTEGDAVVGATVNAGGRLVVRATRVGSDTQLAQMARLVEAAQSGKAEVQRLADRISGVFVPIVVAIAVGTLGVWLGGGFPATAAFTAAVAVLIIACPCALGLATPTALLVGTGRGAQLGILIKGPEVLESTRRVDTIVLDKTGTVTTGRMTLTAVVADDGVDRTELLRLAGGLEHASEHPIARAIASAAADEVGELPTPDGFTNLGGLGVRGTVEGRAVVVGRASLVAGSGRATGGAEGTSDDGGTTPEADLPPALAAAQASAERDGRTAVVVGWDGAARGVLVVADAVKPTSAEAVRQFRILGLTPVLLTGDHRAVAEQVAAEVGIERVIAEVLPEGKVEAVAALQAEGRVVAMVGDGVNDAAALAQADLGLAMGTGTDVAIEAADLTLVRGDLRAAADAIRLSRRTLGTIKGNLFWAFAYNTAAIPLAALGLLSPMLAGAAMAFSSVFVVGNSLRLRSFASRATDGAGAR
>NC_012669.1|WP_015884495.1|4443317_4445081_-|DUF4091-domain-containing-protein
MRRATTDARPYPRPDWTFVLADSLEKVFPDVAPRPMSRPELSGFLGEALAVQLAFLPPAAHSPAAIGPVTVRARGELAHLARLSTVELVPCQLPAFDGHDDGYLRDTPGLYPDLLRPIEQADAGDARAGAPGAVDAAGLAGTLHPRLGYWQAVWVDLQVDDPALAGRRTLTLEMSDADGKPLHTAELAVVVHPVALPALDIVNMHWLHADSLLTYYGVDAFSEEHWRLLEEYVASAAAMRANSLLTPTWTPPLDTAIGGTRPPVQLVGISDDDGGAYAFDFSRLGRWLALCKRHGITTLEVAHLFTQWGATATPAIYVETPSGTEQRFGWHVPATDPSYRELLASLLPALRGYLAEHWSGDVIFHVSDEPRPEMLSDYREARAVVDDLLDGATIADALSDLAFAQDGVVDTPIVATNHVQPFLDAGMTPWVYYCVSQNRDVANRFIALPSVRNRVLGRQLFAFSAPGFLHWGFNFWFAQHSTRPIDPHADTSAGGAFPSGDPFIVYPGPNGEAWPSLRHRVFAQAMDDHRALQLLRTLTDQATARSYVDEGGALAYDAFTYDPEHYLETRRAVDARILAELAGARAT
>NC_012669.1|WP_043347629.1|4442170_4443325_+|AlkZ-family-DNA-glycosylase
MVTTTRRQVLAFRLRQQHLARRLGAARMGEATATCGVRNSPAGSAPVALLARVNGVSEDRVSAALSGKHLVEVEDPRLVPALVRPEDLAVFTVGGIDTDDASLRVKFGRGAAKALAAAGIRPIEALNRVVEAAHAELAGGVRSTGELSAAMTARLPGPMSLWCQRCGSRHIHESLFRLPSAAGISCLAPRSGRQVRYVRVDKWLGTDVPEVGSPAARDAGRELLRRFLHCYGPATPGEFADWTRTAAGAARHRFAEIADDLQDVSWDGHTGSVLRDDVDELRDARTPSGVRLLPPNDPYLLAPDRAALIPDPSSRTVLWPALSAPGAVVIDGEIVATWRSQKKGTALRVQISPFDRPIATAAALIEQEAHLLADLRGCQRVEVT
>NC_012669.1|WP_015884493.1|4440407_4441883_+|glutamate-1-semialdehyde-2,1-aminomutase
MSAASTMDEVFDRARAAIPGGVSSPVRAFGSVGGTPRFIASASGPHVTDVDGREYVDLVGSWGPAILGHAHPEVVAAVQEAASRGLSFGAPTLGEVELAEEIRRRVPPAERVRLVSTGTEATMTAIRLARGVTGRDLVVKFAGCYHGHVDALLAAAGSGLATLALPGSAGVTPATAAETLVLPYGDVPSLEAAFAAHDGRIAAVITEAAPANMGVVEPGTFNAEIRRVTAAHGALMICDEVLTGFRTGPSGWWGVENDVADGAAALAAAADQGSGARARTPATSSYSPVSDLAADVRARRDDPLAADAGPSTTAVWTPDLFTFGKVVGGGMPVAAIGGPAAIMDALAPLGPVYQAGTLSGNPVAVAAGLATLRLADDAVYARLADTSRAVRTGLTEALDAVGLAHAVSSAASLFSVAFRDERPRGWDDVQAQETFRYPAFFHAMLDAGVALPPSVFEAWFVSAAHDDAAVGRVLDALPGAARAAAAVVAPR
>NC_012669.1|WP_015884492.1|4439251_4440262_+|porphobilinogen-synthase
MTVLPPGSPRPRRLRATPALRRLTAEHRLDARDLVLPLFLREGASEAVPIASMPGVVQHSRDSLRAEVVRAAEAGIGGVMLFGVPTTRDAEGSGADDPDGVLNTGIRDAIAEVGDAVVVMADLCLDEFTDHGHCGVLDGAGRVDNDATLERYAAMALAQADGGAHVLGLSGMMDGQVGHVRAALDDAGRADTALLAYSAKYASAFYGPFRDAVESRLVGDRRAYQLDPANRREGLRETLLDLAEGADAVMVKPALAYLDVLADVASASDVPVWAYQVSGEYAMVEAAAANGWIDRERAVRETLLSIVRAGADAVLTYWALDVAGWLRADGGAGGAR
>NC_012669.1|WP_015884491.1|4437887_4439255_+|uroporphyrinogen-III-synthase
MEYVLGTRGTLVSERSLTGRTVLVPRTDPDDAIVRAVEDAGAHVLRAELLAFVPPDDVAPLDAALGRLAAGDYDWLAVTSPRTVDALVAAARRGAAGGSRGAGAPEAGSPVVGPLGAAEPAARTLGGPEPAARTLAATEPVVHTLGGPEPAARTLAAALGATRVAAVGPATAAALDAAGVPVHLVPGDRAPSSAAGLVAAWPAAPTTEVAPGGRGSGPHPLPHPPATTSARGLRLEGDPDAPEPETRVLLPQSARAEPTLAEGLAAKGWDVDAVTAYRTVPGTPPGPEIARAWTAGEVDAVVLTSGSAAEHLLALLGPPPAATRVCAIGDVTAAAASRLGIPVAVTADQPTPSAIVAALAHALSAPPFAPAPPTPARPPAPAPAPAPSPAPAPAPAPAPSAVGAVSGARERSHGPEPAPTTEGGHASGFEPQPQPEPEPQPEPEPRRRPLPKDPS
>NC_012669.1|WP_144017005.1|4450164_4451088_-|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein
MLDAARLQFGLVTTAQCEAAGITRNARAVRVARGDWVRPTRGVYDLAPGAAVDMDPGWRRRRGAVLGLLAYGPEAVAVGTSALALHGLWGLPLRSLPQVALPSGDSRLSRDGIRVRRFTVPRVTRTGEGYAVAPVGLALAQAIPELDRDHAVALLDSALNLERIDGADIAKVRDVVRHRRGASRAAGWWDLVDARSESTYETFARLECHDAGIAPDELQVPMVLPDGRRARGDLGWQIDPRTWLLAEIEGEDAHAARRARRKDQRRQNGLTISGEATVLRYDPADVWTGVIPAEVKEFLRSRRRRGA
>NC_012669.1|WP_015884502.1|4451546_4452347_-|ABC-transporter-permease
MTAATASVPVRPARPPRSALRLGLLHAKYQFLEAIRIPIAVIGTMMFPTLAMVFFVVPNQAVAQNPVFATAAVAQLGMFSIMATCLFTYGTGVAEDRDRPFDPYMRTLPAGASAQMIGRVANGLIFAALGLLPLVLAGWILTAATLSWSRLLVSVLTILALAIPFTMLGLGIGYSLPSKAAIAVVQVVLFPLAFAGGLFLPPQMFPGWLDAFSQALPSRAGRDLLVQVTSGEPAYGLALPVLLGWTVLFAVFVVWAYRRDEGRRFR
>NC_012669.1|WP_015884503.1|4452343_4453306_-|ABC-transporter-ATP-binding-protein
MTAVISLDHATRRYGDVVALDDVSLEVPAGELVGLLGPNGAGKSTLLNLVNGLRPTTSGTVRIFGADPRVPASRIQLGTTPQETGLPPTLRVGEVVDFVGGHYPDPMSRDELLSRFGLADLAQRQTGGLSGGQKRRLAVALSIVGRPRLVLLDEPTTGLDVEARRLLWDAVREYHADGATIVVTSHYLEEIEALAQRVVVIGHGHVLADDDLATIVGRVSARHVRLRLAGDARAVVDALPGVVDATADGDRWTILTTDSDAVIRALVTQGVTFSGLEVRGASLEEAFLAMTASDDDGDASSGAHVAPSSSPSDQTQGALR
>NC_012669.1|WP_015884504.1|4453302_4453605_-|transcriptional-regulator
MNDGLDPVIHAPARLRLVVVLAQLGPEDRISFPRVQKELDMTAGNLSTHVRKLEDAGYVAVTKTHERRTPVTYLALTSEGRVALERYRAAVTSLLKGAVS
>NC_012669.1|WP_015884505.1|4453601_4454264_-|hypothetical-protein
MTDPREGGPSSEVEPSEGLDAAESLRILGADAARVRVRIEPDGRVLFLVWGIAWTIGYLTLWVASRDDGVPPGWAFVVFTAALVIAIVLTAVHIARRTMGVRGASAVSGAMYGWAWSLSFVMLGVLLRTMGEHGASEELIGLMANGISCLIVGALYMAGAAIWRSWSQFALGVWIVLVGAVATLSGVPTAFLIMATAGGGGMLVGALLTRLSLRRATASR
>NC_012669.1|WP_015884506.1|4454441_4455284_+|CPBP-family-intramembrane-metalloprotease
MATSIADSPWRTFWNRGGVWRAVLLAVVYLAIYLAAGLLAGTLFRDQLGDDDVFATPMSVFAGLTFALIIGAIVLTAFLASVRWFGPVFGPQPIGGRAWMWVIPVLVAVPIVLRLAGIDYESYASGVVLVTLLSGLLIGFCEEVLCRGIVVKMLRDGGRSEWTVMAVSSLIFALLHSANLLAGMAPATVALTIVYTFGFGACMYLTLRVTGRLIWPIVLHGLFDPTLFLATGGIDAESGEQTSSLLALAAPFNFVFIAAGLVALLVVRGRVQRVPEPQAA
>NC_012669.1|WP_015884507.1|4455290_4456277_-|2-dehydropantoate-2-reductase
MRYVIIGAGAVGATIGASLHEAGRDVVLVARGEHLRVLREDGLTFATPSSTRVLPIPAAGGPDDLVLRPDDVLVLATKSQDTAGALAAWAPATVDGGTAGERLTVVCAQNGVDNERQVLRRFGHVVAVTVWLPATHLRPGVVVAPGDPAPGVLTLGRYPSGVDATVELIGTDLAAGGFVAPVRDDVMRWKYAKLLGNLGNAADALFGRDDDAASLVRRARQEGEAALEAAGIPWTSDEEQSAMRSAFGVGTVPGFERGGSSTWQSLARGTGSVEVDYLNGEIVLLGRTHGVPTPVNAALQARAAVAAAAGAAPGSGRAAELLAALAAQ
>NC_012669.1|WP_043347642.1|4456447_4457353_+|CPBP-family-intramembrane-metalloprotease
MTDAEGAPPGAPGPADARASAPTPTDRPAAPTPAPTDRPGAPAPSPAATRRRLTWEIWLVLGVSLLGSATLAILNLVDRLTIDIPLGDQSATLNPPANERPWLDLLYQLRRIAFLALPAFLALYLLSANGRSAARRIGLDLTRPWKDLRDGVVLAALVGIPGLGVYAIGRALGITVEVRASGLDGIWWTVPVLILAALANALVEEVVVVGYLAERLRELRWQVPAILVVSALLRGSYHLYQGPGMAIGNVAMGVLFAWYYLSPRWGHRVLPLVIAHTLIDVVAFVGYQLLPEAWLTALGLA
>NC_012669.1|WP_015884509.1|4457365_4457956_-|HdeD-family-acid-resistance-protein
MSESPGAPAPLFSQLAGQVWYYPVIRGVLAIILGILALVWPGATVLTLVLLLGAFWVVDGIVELVDGIRWRGLPGAGWRIFFGIVSIIAGLVLLFRPGMSLDVIIIVGGIWAILGGIFIVVAAFQARPLPGWGWTLFTGIVIAILGILLLVQPGITAAALVLTLGIWAIVVGLVLVILGFQIRSAGKRAANDARTA
>NC_012669.1|WP_015884510.1|4458108_4460859_+|flippase-like-domain-containing-protein
MSEADAPGTTVPQAPAPSVPPPTRTVEIIDVPAHRLRRPGDLVAMILALLGVVLVLLLAVYAHRTTEGVTEDIENALPDFLERLLDIPLNLLEGLVTFLLPLLVIVERLIRRQVRVVLEALAAAVVAALLTGAGAWLLRSFAPDALVDGLAIASGTALSPAVAAIAALLTTIGSRDRRRAVGWSWNLLWIVLVLQVLMGAMSLPGALVSVLLGRALGLAARYLWGVRGERAYGRDLVTAIRRAGLDPLRIQRIADPEDLAEATAELVTTNSPIGYVTEHPDALPARAERRAEIREERGADDDGAPPTSSPAFMAATSEQADDGEPAPFSSPTPVVTLDDESAPADAGPPAPIRLRVSDPATVALAREGENRVYAVVDADGTRWDVVVLDGDRQVVGTLAAFWSTIRLKGLEQRAVVSLRAAAARAALMTYAAAAAGVRAPRLQGIADEEDSVLLVGEHVSSATTLSAMQPDDITDELLDGAWEQLRVAHDAGLAHRAITGDAILVASGRDVWLTAWENGEIAASELARRLDLAQMLALLALTVGPERAMASASRSLTEEQLVAIAPILQPVALPPATRAAARRDKQVLARVQNLLVDLIPTAQTEPMQLARFSARTVVTVTVAVIAGFILLTTLNFDQIIAAVREANPVWMVVAFLLGLLTYLGSAMSLVAFSPEKLPLWRTTLVQVAASVITLVAPAGIGPAALNLRYLQKNRIATPMALATVALVQVSQFVTTVLLLLVIALVTGSSGALDSLPSGAVLLVVALVLVAASTAFAFPAVRRWVLARLVPMLRQVWPRVVWVVGQPGRLAMGIGGNLIMTIGYLAAFQAALEAFAQSVPLTSLAIIYLVGTAAGSAIPTPGGVGTVELALTSGLRTAGVPTAVAASSAVLFRVLTFWGRVPLGWLAMRYLQKRDAI

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Crispr_ID: NC_012669_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012669_11

4631392-4631568

Orphan

Consensus_repeat	Method
GACCTCGCCGCCGGCGATCGTCAC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_012669_11

>merge|NC_012669|11|4631392-4631568|CRISPRCasFinder
GACCTCGCCGCCGGCGATCGTCACGAGTGCGCCGGCGACGTCGAACGGCTCGTCCGTCCCGGCCCAGACGTGCCGGACCTCGCCGCCGGCGATCGTCACATCGGTGGTGCCCTCGAAGTCGTCGGTCAGACCCGTGATCCCGACGACCCGGGCGAACTCGCCGGAGCCGATCGTGAT

>NC_012669|11|10|4631392-4631568|CRISPRCasFinder
GACCTCGCCGCCGGCGATCGTCAC	GAGTGCGCCGGCGACGTCGAACGGCTCGTCCGTCCCGGCCCAGACGTGCCG
GACCTCGCCGCCGGCGATCGTCAC	ATCGGTGGTGCCCTCGAAGTCGTCGGTCAGACCCGTGATCCCGACGACCCGGGC
GAACTCGCCGGAGCCGATCGTGAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_012669.1\|WP_015884677.1\|4635053_4637948_-\|cation-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319775
NC_012669.1\|WP_050761780.1\|4627678_4629049_-\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NC_012669.1\|WP_015884668.1\|4621507_4622296_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NC_012669.1\|WP_015884664.1\|4617454_4618408_+\|PfkB-domain-containing-protein	unknown	unknown	gnl\|CDD\|275175
NC_012669.1\|WP_015884682.1\|4643174_4644626_-\|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|131739
NC_012669.1\|WP_015884676.1\|4633890_4634964_+\|inositol-3-phosphate-synthase	unknown	unknown	gnl\|CDD\|132491
NC_012669.1\|WP_015884671.1\|4625795_4626674_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012669.1\|WP_015884683.1\|4644758_4645283_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239645
NC_012669.1\|WP_015884667.1\|4620617_4621511_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293807
NC_012669.1\|WP_015884672.1\|4626684_4627665_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_012669.1\|WP_015884665.1\|4618514_4619261_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_012669.1\|WP_015884679.1\|4639790_4640156_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NC_012669.1\|WP_015884675.1\|4633264_4633894_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367559
NC_012669.1\|WP_015884666.1\|4619336_4620614_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_012669.1\|WP_144017009.1\|4638449_4639688_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_012669.1\|WP_015884669.1\|4622583_4624752_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271202
NC_012669.1\|WP_015884684.1\|4645321_4647433_+\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_015884680.1\|4640379_4641531_+\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_015884681.1\|4641788_4643102_-\|epoxide-hydrolase	unknown	unknown	gnl\|CDD\|377658
NC_012669.1\|WP_015884670.1\|4624759_4625770_-\|aldose-1-epimerase	unknown	unknown	gnl\|CDD\|185695

Protein	Function_ID	Function_description	E-value
NC_012669.1\|WP_015884677.1\|4635053_4637948_-\|cation-translocating-P-type-ATPase	gnl\|CDD\|319775	cd02080, P-type_ATPase_cation, P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase. This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_012669.1\|WP_050761780.1\|4627678_4629049_-\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	2.02497e-29
NC_012669.1\|WP_015884668.1\|4621507_4622296_+\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	2.80444e-71
NC_012669.1\|WP_015884664.1\|4617454_4618408_+\|PfkB-domain-containing-protein	gnl\|CDD\|275175	TIGR04382, myo-inositol_catabolism_protein, 5-dehydro-2-deoxygluconokinase. All members of the seed alignment for this model are translated from the iolC gene of known or putative inositol catabolism operons. Members with characterized function are 5-dehydro-2-deoxygluconokinase, the enzyme catalyzing the fifth step in degradation from myo-inositol or closely related compounds. Note that many members of this family are fusion proteins with an additional C-terminal domain, of unknown function, described by pfam09863. [Energy metabolism, Sugars].	8.03987e-94
NC_012669.1\|WP_015884682.1\|4643174_4644626_-\|CCA-tRNA-nucleotidyltransferase	gnl\|CDD\|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	0
NC_012669.1\|WP_015884676.1\|4633890_4634964_+\|inositol-3-phosphate-synthase	gnl\|CDD\|132491	TIGR03450, mycothiol_INO1, inositol 1-phosphate synthase, Actinobacterial type. This enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid.	0
NC_012669.1\|WP_015884671.1\|4625795_4626674_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	7.58132e-86
NC_012669.1\|WP_015884683.1\|4644758_4645283_+\|NUDIX-hydrolase	gnl\|CDD\|239645	cd03673, Ap6A_hydrolase, Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most preferred substrate, hydrolyzes to produce two ATP molecules, which is a novel hydrolysis mode for Ap6A. These results indicate that Ap6A hydrolase is a diadenosine polyphosphate hydrolase. It requires the presence of a divalent cation, such as Mn2+, Mg2+, Zn2+, and Co2+, for activity. Members of the Nudix superfamily are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site.	8.41655e-50
NC_012669.1\|WP_015884667.1\|4620617_4621511_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	5.16278e-29
NC_012669.1\|WP_015884672.1\|4626684_4627665_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.08288e-81
NC_012669.1\|WP_015884665.1\|4618514_4619261_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	2.10836e-56
NC_012669.1\|WP_015884679.1\|4639790_4640156_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	2.59563e-28
NC_012669.1\|WP_015884675.1\|4633264_4633894_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	2.65422e-13
NC_012669.1\|WP_015884666.1\|4619336_4620614_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.06603e-36
NC_012669.1\|WP_144017009.1\|4638449_4639688_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.6727e-30
NC_012669.1\|WP_015884669.1\|4622583_4624752_-\|hypothetical-protein	gnl\|CDD\|271202	cd04794, euk_LANCL, Eukaryotic Lanthionine synthetase C-like protein. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 and LANCL2 (testes-specific adriamycin sensitivity protein) were thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs. More recently, they have been associated with signal transduction processes and insulin sensitization. In particular, LANCL2 has been shown to bind abscisic acid (ABA), and this interaction may play a role in signaling pathways triggered by ABA, such as in human granulocytes and rat insulinoma cells. This eukaryotic LANCL family also includes Arabidopsis GCR2.	7.75691e-06
NC_012669.1\|WP_015884681.1\|4641788_4643102_-\|epoxide-hydrolase	gnl\|CDD\|377658	pfam06441, EHN, Epoxide hydrolase N-terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.	1.97787e-41
NC_012669.1\|WP_015884670.1\|4624759_4625770_-\|aldose-1-epimerase	gnl\|CDD\|185695	cd01081, Aldose_epim, aldose 1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism; they catalyze the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate and the histidine as the active site acid to protonate the C-5 ring oxygen.	1.36118e-31

>NC_012669.1|WP_050761780.1|4627678_4629049_-|carbohydrate-ABC-transporter-substrate-binding-protein
MTVVNGNWQLSRRGLLGGGLGLAAGAGMLAACGPSDGSGGSDGEPPEDLGSPEEGRLVVWGGVAPETGPQALVDAFMAKYPDIEVEYTRYVNDEEGILKLDTALQGGVPIDVYFSYGTVDVVRRSQAALALDLTDLAREDDLAQIFVQDEPISTLVDGKLFSIPTTHFPNFVVINQDAMEAAGIEIPFDWTVDDYHQIAQEFASAGFDVGAYNVPRHEAVGLGGDYLYTEDGTESNLDHPLVRERLEATLAMEDDGSIFTQERITAEGIGGYAQNYFLDGTFAMMLDGTIIARYVKNLEEYPHDFRTTFRPYPRLAAGEPYINPGVRGDDVQISAKSKYASAAWTFVKFWMGEGAELVTPSGKVSPFQYEDGPSDSLNEALFGPDADELFDVESFEQTFFAAEPPLAVRSITTAFTEISSIKSQIEEEIRLRTKSIDDGIAEMKTLADEAIDSWLE
>NC_012669.1|WP_015884672.1|4626684_4627665_-|sugar-ABC-transporter-permease
MTLISEGAKPDRAGKLPRGSAPSTPDRPQRSVLVNGYRWWIPWLFVIPTVLCVLAFLVVPMVSGLFIAFTDWDVVSGLGGIRWIGLGNFQELVQDDMFWSSALRTLFYAGVGTPLTITVGLFLGLALNRPMPARGVIRAIFFLPSLVNVIAAGTVWLTLLNPTSGMVNQFLRALGLTDVPGWFTSEQWALPAIVLMSVWISAGYVAILIIAALQDLPPELYESAKLDGAGTTRQFTAITLPGLVPILTFLLITSFIGRSQGFGLIQFMTGGGPGDSTTVLSYYMYEVGFHWYRFGYAAAIGVMSMLAVLALSIALFKLQRGRGLYT
>NC_012669.1|WP_015884671.1|4625795_4626674_-|carbohydrate-ABC-transporter-permease
MSADAARYAPRPSLVKRQRRERASWIGRGVVMSLLAIVFLIPFLWMVSSSLKQNLDIFEIPIRWIPNPVDWSNYVDVWTGERSMVRYFSNSTIVVVATIIGELAVVTLAGYAFGQLRFKGQNVLFIAFLATSMVPAQLMLVPRFMFFRELGLYDTLWALILPGLASVFATFLLRQHFASAPRELGEAARIDGAGEGRIFWSIYLPMARPALAALAILIFDSTWNDYESALIMITDEAKYTVPLGLTRFMSEDGTVSMGPAMAGSVSSLIPVLVIFLIFQRHFLRSMARVGLR
>NC_012669.1|WP_015884670.1|4624759_4625770_-|aldose-1-epimerase
MSADAAARPGVSTRSGWEAVHLTTDDLEVVVIPGKGGDVSSIRQRSTDIELLWTPRWGLRPPTALPLPGVPETLALDRSGGGWNTMFPNAGRASVEYGVDWGFHGETWLAPFTWEPVADGVEMTTALARSPFVVTKTVVAVADAVTVTESVEHVGARPVDVLWCQHPAFGAPLIGPATTVEVTGCVVHPDMPDDVPPTPAPPRWPAHTEVDQSAVDLSRLDAAGSGGARLAFLGSFDDDQVHARIHNPEIGLMVELSWSREDFPFAWYWYESGGRQDYPWYGTAHSLALEPASGYPSGVRRARELTGTELTIEPGKTVTKSVTMRVVSSRKTNPER
>NC_012669.1|WP_015884669.1|4622583_4624752_-|hypothetical-protein
MHVLKNADSSFGLRVGAPGGAAAEQAAPLRATVWSGEAGAAPVTLDAGYDSLRGTGGEWLGTGRLDTPGGATLRFTDRWTTEGDSLRLRREVRVHGDAPGGFASVAALRVVGAEPWPQMEWFAPGMIYGNFDHMRDNSFGAGNYYEPGNYTVWIREDRMPAPLLATRLPDGATVAVLDSAPDGRTSAAEGQSFSREPMVAGEFRFGAVLAEERPDGTALGYAMPGSEGSLSYGPKGGGEHGATAEQRWRYRFNPLTDGFTHRYEVTFRFDRAADTNELITSSWRWAWRTLDPRPNPQDVETMRSTMVDVLAENFLEVSDPVGGNRAGVKFVMPAIPGGKEHPDSKVILGFTGYALGSAEMMLVEAARDPGSERSRALVRDAEKAIDVFVRRPVDPPLDEGFMLRSGAPAVSTWPTGREVTTEQAIYLRSFTDDMKSLMRAYEREVRAGRDRSEWLAWVRTFADWLLTQEQPGGGFPRSWRALSGELLSASTTGTYNVVPFYAQLYRVTGHEPYLDAALRAGEFAWGAGGHARGRFTGGTIDNPDVVDKEAATIALEAYLALHHLTHEETWLERARIAADVAETWMYIWDVPMPEDADDAELHWKRGTPTVGIQLIATGHSLNDAYMAWDVESYARLAQETADPHYLDVARILLHNTKAMVGTPEDHRGTRGPGWQQEHYCFTLARGMGRHREWLPWVTVSHLRGINDLIDYDADLYQELAGL
>NC_012669.1|WP_015884668.1|4621507_4622296_+|SDR-family-oxidoreductase
MKAALITGASRGIGAGCALTFAREGYAVGINHRSSGQDAERVAEQCRELGVEAEVFAADVADVGESQAMVEQFVERFGRIDVLVNNAGGALRMPPGGFIDMPTAYWDSQIALNLNAAAYCAQAAARAMVAQEIAGAIISISSIHGDVTWVRRKALPYSAAKAGLTMMTKSLGVELIQHGINVNCIAPGLIHTKALDRYSERDLTAFNRKIPFGGGGEPADIAELAVFLADKAKSRFIVGQTITVDGGQSIDGAIDAMLDDAF
>NC_012669.1|WP_015884667.1|4620617_4621511_+|MBL-fold-metallo-hydrolase
MEHFTQIVQDVLLLKVPFTGVWTGVTLVLGEGPPILVDSGGMAETVDSTIVPALAELGMGLSDIGWVLATHIHGDHVGGIARMRQLAPSIQVGVLRESDERMRDPLAYSREIRAAFPEHSAAPPPVLDGVTPDRLLDDGDMVGPLRTIHTPGHDTDACCFFDVRSGTVITGDSLQLNGTVSQGCALLFDPERYLPSLQRLLALPVRNIVCGHPYLPLGEVAIGEDAARQFLAACIGCYEHDRGFVAGMAAAGVTDPHTVARALVAAVDGVEPAKLFLPMHTVAAYQELAAADRSTRT
>NC_012669.1|WP_015884666.1|4619336_4620614_+|Gfo/Idh/MocA-family-oxidoreductase
MERIPLAIVGAGGMGTRHLFGMAELERAGLNPFDLVAVCDVDPARAEHVADEARARLGRRPAACADVAAAQRLGAVAVDITTVPQAHHSLAADAVALGLDVMVEKPVGLTIAAARQLEASVAGSDRILSVAENFRRDPTNRLVKALVDGGVLGEPRYFHQSSGGGGNLMAISMWRHMKDESGILFDAGTHYTDMMEYYLGPVTSVYAQMRLFEPVRYNPAATGGAPASNPGGVYGQSQAAMPAEFEATADDALFAMVNFASGAVGQYAENRAEHGRDSWARSVHGSAGAVEIPKDRSGQPLVLTLDRTHTYTGAEILPLVPEFQLDDATAALFGGAQATAYGLDFETVDRLLLAVEYAEFGSCISSRTRPEVGLDEGLRAIALCYAMMESGAAGGTLVTVDDVLDGSVSGYQASIDAAIGIGANA
>NC_012669.1|WP_015884665.1|4618514_4619261_+|GntR-family-transcriptional-regulator
MAEEHAVIQVALDRASPVPLYFQLAEQLTSAITDGHAQPGDPFENEVAMSERLGLSRPTVRRAIHHLVDQGLLVRKRGLGTFVASRRVHRRVSKGSLYEDLSIQGRHPSTEVLKVASEQYPKAATALELDPGTELLALRRLRFADGEPLAIMQNWLPPRHSSITQEQLEARGLYAVLRDHGVGSVVAHQSVSARLPTAEERALLKISSRLPVIAVSRTAFDPSGAPVEHAEHVYRSDGYTIDLVLEEN
>NC_012669.1|WP_015884664.1|4617454_4618408_+|PfkB-domain-containing-protein
MSAQVTKELDLVSVGRVVVDLYPAEDGRAPKDVENYRQYLGGSPTNVAVAAARAGLRSAVVTRTGDDLFHEFVVDQLASFGVDARWVRAVPGRRTTLAVCDLRDPSSPALQFFQDTPPPTDALDAAELVAASSSSHMLWITASGFATDRSAAAHDAALAAAEHTFLDLDHRPDFWADERALRDRLRPVLPQVDTVVGNEKECSIALGRPGTAEELGRVLLDEGPRLAVVKRGEEGVVAVTRDAVLSVPAVPVRVVNGLGAGDAFGGWLVSGMSAGVPLDVTLRRATAAGAIVASRRGCSVAMPTPAEVDELLERHGR
>NC_012669.1|WP_015884675.1|4633264_4633894_+|helix-turn-helix-transcriptional-regulator
MRNRGDVLELAILGRLADGPLHGYELRKRLGVVLGAFRTLSFGSLYPRLRALEEKGWIRPVDTAALPHALAGRRSRVVYELTADGKERLAGALSRAEPASWDDETFDVRFSMFGETDPETRLRILEGRRTRVLERREAYRSAGTRGRERRDTYTLELQRHGLELLDREVSWLEDLIAKERSGTTDHPASDTPQTPDGRPAGREPEKENP
>NC_012669.1|WP_015884676.1|4633890_4634964_+|inositol-3-phosphate-synthase
MSSIRVAIAGVGNCASSLVQGVHYYRDADPNGSVPGLMHVQFGEYHVGDLEFVAAFDVDAKKVGFDLSEAINASENNTIKIADVPPLDVPVQRGPTLDGLGKYYRETITEASGDAVDVAQALRDARADVLVCYLPVGSENAAKHYAQAAIDAGVAFVNALPVFIAGTPEWAEKFRAAGVPIVGDDIKSQVGATITHRVLARLFQDRGVVLDRTYQLNVGGNMDFKNMLERDRLESKKISKTQAVTSNIDHDLGSRNVHIGPSDYVQWLDDRKWAYVRLEGRAFGEAPLNLEYKLEVWDSPNSAGIIIDAVRAAKIAKDRGIGGPILSASSYFMKSPPEQYPDDLARAKVEAFIAGEA
>NC_012669.1|WP_015884677.1|4635053_4637948_-|cation-translocating-P-type-ATPase
MEPAEHAPTPSTPRPSGPGPRPAPSVAAGTTSTAPDPSTRDAADVARDLGVDLDVGLSRAEAARRLAENGPNDLRETLPVPLWRRVLAQFQDPLVYLLLVAVAISLVAWIVEGAEGLPIDSVVILAIVILNAVLGYVQEQRAESAVAALRDMTAATSTVLRDGELRTVASAELVTGDVLVLAEGDAVGADARLFAATALRVSESSLTGESEAVTKNTRTLPEPAPLGDRLDMVFRGTAVAQGVGRAVVTSTGMGTQMGAIAEMLEATEADPTPLQREISSVSKLLGITVIAIAVVVMVTIALVNQVDELSDAVTVLLLGVSLAVAAVPEGLPAILSVVLAIGVQRLARRNAVVKKLSSVETLGSASVICSDKTGTLTKNEMTIECIVTASGRVDLTGVGYRPDGVALHKGHRLEDSRLAREARIALGGGMLANEAQLLERDGEWQIQGDPTEAAFLVAARKLDRTIEEAAHYERQGSVPFTSERKRMSVLGRRDTDGQLVLISKGAPDVLLSFCTHVVVGEDVVELDDARRERILADVEGLSAQAFRTLAVAYRPADDLEPADGSADLDESAEHDLVYVGVVGIIDPPRDEVALAVREAHRAGIRVVMITGDHPATAARIAADLGIVEPGAEALTGRELDAIDDDELTLVVRRVSIYARVAPEHKLRIVDALQADGLVVAMTGDGVNDAPALKSADIGVAMGITGTEVTKEAGDMILGDDNFATIVAAVRQGRVIFDNIRKFLRYLLSSNMGEVLTVFLGVVLAGVIGLAGASDEHVVLPLLATQILWINLVTDSGPALAMGVDPEIDDVMARRPRALTDRIIDGRMWSGVISIGLVMAVATLVTIDVFLPGGLIDGTDTLDVARTAGFTTLVLAQLFNALNSRSETTTAFHRLFVNRWLWGALALGVVLQVAVVEVPVLQHAFGTASLDLAHWGVCVALASAVLWFDELRKWVWRVRHPEVPA
>NC_012669.1|WP_144017009.1|4638449_4639688_+|MFS-transporter
MFQVGLASLLFFSPESQGTAAAIAGAFAVMLAPFTIVGPFAGVLLDRWQRRQVLVWGNAVRVVLTLGMAALMLAGGVSGWIYAVGLAALSVNRFLLAGLSAGLPRVVDRPLLLTANSITPTLGAGAAFVGGGIGFVLGLAFEPGRVKDSSALVCAAVVFAVASLLALRLGRTQLGPDRPAEASVHSEIAKVARGLVDGARYLAARRTPGQALLAMATHRFLYGVVFIASILIARNLLDPGNQDAGLATFAVVVGLTGAGGAVAMVLTPTLSRHTGPQAWIAIMLLLAAASQLLLVTTPSRAVVYAGAGLLGLAAQGTKIAVDTIVQRDTEDSYRGRAFAFYDVLYNAAFVGAAALAAFTLPDTGWSRAVFVALAVAYALAALVMWTRGARSPRPVGSAEVSDVGPSSTTLPA
>NC_012669.1|WP_015884679.1|4639790_4640156_-|VOC-family-protein
MTEKSARRWIDYVELTVTDLPAAIAFYERAFGWEFTSYGEGYAGIRGATSDDPEVGGLSLGDSVRPGGPFLLFSSDDLDASVVAVTDAGGAVVQGPYSFPGGRRFHFTDPSGNELGVYQDD
>NC_012669.1|WP_015884680.1|4640379_4641531_+|hypothetical-protein
MTARSAPTDHPPTPAHDHPARGAVGHPAGTRATPDATRRLTGTALITSAVTTTLVGFFAAAPDLNPFLAEGNALGRALLPGPVLTWTLLAVALLGLATATAALLRPRSGDAGRLVAPVAALQVVAFGFLAQGAQTLSAAGYLMSLAVPVLVVWMAVQVFRTRPGWRIPIALGGVLAVVGIVVARDAFATQLGGVMSGFARERWGLLGVVIPLATATAWAGLALLRAWRRGSLHRATAWVTRHRRLFTVLAALGPLPYALARLTWLTPWAMFGGEGVPLSVKIQGLALSSGAWLGFFLTLGLILPWGERFPRWFPRRAGQPVPPAAAIIPGGIVAVMLSGAAIPLLLMMGASGAVLFPAWFWGPMLALAVWGYAGHRAGIDVSR
>NC_012669.1|WP_015884681.1|4641788_4643102_-|epoxide-hydrolase
MEFRELTIDVPQAVLDDLTERLARTRWPNEPTGGEAGGLGEVRRLVSHWAEHYDWSEVQDRLNRWTHRVARVDGRDVHVVHERSAAPGAVPLLLLHGWPDSFYRFAHVVDRLTRRDGDDDDGPAFDVVVPSLPGYVFSEQPEPGGATLAAVAETIAQVMAGLGYERYVVHGGDWGAAIAQEIARAHPERVLGLHLTDVPFPNMFTVDRESATDAERAYLGASMAWAESASYFTVQSGAPLELAYGLSDSPVGLAGWLGDKFRAWSQAPLADDDVLTNVMLYWVTNTVRSSFRFYAEGLGGEWDSGDAAEWGGSAESGGVAESGGAAESGGSGGWGGDAAGYGSVGSGEWGGDAAGSGSGDDAGAAAADWSPRIEVPTAIALFPADLGGPAPREYVERFFDVRRYTLMPRGGHFAALEEPALLVDDLRAFAAQLAEAR
>NC_012669.1|WP_015884682.1|4643174_4644626_-|CCA-tRNA-nucleotidyltransferase
MPTPEAQRPAQLMRTALGVLAGIAADVDPLGDLFAAGGHEIALVGGPVRDAFLGRGSSDLDFATSARPEQTEAILARWGDAVWDVGRAFGTIGAGRGDVVVEVTTYRTEAYDAGSRKPAVEYGDTLDGDLSRRDFTINAMAVRLPDLTFVDPHHGLDDLAAHVLRTPVSAEQSFDDDPLRMMRAARFAAQLRVDVAPDVMAAMTAMAGRLAIVSAERVQAELTKLLLAPAPRRGLELMVETGLADVVLPELPAMKLEIDEHHRHKDVYEHSLTVLDQAIDLETGPDGPVPAPDLVLRLAALLHDVGKPATRRNEPGGRVSFHHHEVVGAKLARKRLAALRYDKATIADVTTLIALHLRFHGYGDGAWTDSAVRRYVTDAGPELERLHRLTRADCTTRNRRKAERLSHAYDDLERRIAELAEKEELAAIRPDLDGAAIMATLGIGPGPVVGEAYRFLLELRMERGPVEPDVARAELLAWWAARE
>NC_012669.1|WP_015884683.1|4644758_4645283_+|NUDIX-hydrolase
MSSQSPAQPAAGRPAPPTVRLERPTAALPVVDETSAGGLVVDVVDGAAYTAVIARRNRAGRLEWCLPKGHLEGAETAEQAAVREIAEETGITSQVLRHLATIDYWFAGHDRRVHKVVHHYLLEATGGELTTENDPDHEAEDVAWVRLDEVSARLAYPNERRIVATARDLLAGPL
>NC_012669.1|WP_015884684.1|4645321_4647433_+|hypothetical-protein
MAAALVALLGLGGAALATTPAVADEAGGVSVEITDLLPAVALPDDELVIRGTVENTADSVLEDPTVSLRVQWRTPNWRTALELWLDPEGGVASRNVVTQPLDGDLAPGDRVPFEIRIPVEEAGVAATESSWGARGLEVRAGDATRSASDRTVGVFYPDTDPLPAPTELSVLLPLAPDASEWEAARAEERPVGDVAAERLTELAGLGGPDVSWALDPSVLASDPLPAEPDDDPTAPATDGTGGTTDPPSGTEAPTDGGADDDGAAADGADAVADLTRTLRTASAGRDVVALPYGDADSGNVIRAGQPSLLAQARERGAGLTDEADLRVLADVAWPAGGELDQQVADGLADAGYDTLVMPSSLVAPTTPITYTPTGRASLPASDGTTLDAALWDPELSTALGGAGTDELTSRQLLLGLTAVIARERPLDARGLLAVVDREAMADADLDALAERLEALEQAPWLDVVPLRSLLGRPDEALDRAALPAEGDPLDDGTELTLARTAAELTRADGVATALADPEPVLRGVRDDLLSVSSTAWRGRPEGRLATLEDATAALDDVLSGIGVTPPGSHINLIAQEGSIPIDVTNALDQEVTVTVVLSSSDPVLVVEDTPQLTLPPADGGTPSVTTVRVPVHGVKNGDVDVQVELRTPSGTVVGEEASFAIRVRADWETVGTAVVAGILGLLLVIGLYRTIRRGPRKATGEPS

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Crispr_ID: NC_012669_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012669_12

4641576-4641701

Orphan

Consensus_repeat	Method
GACCAACCACACGGTCGATCCGCGGGCACCCAGACCCCACCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012669_12

>merge|NC_012669|12|4641576-4641701|CRISPRCasFinder
GACCAACCACACGGTCGATCCGCGGGCACCCAGACCCCACCCCCCGACCGTGTAGTTCTTCCCCCACCGCCGGGCTTCGAGAGACCAACCACACGGTCGATCCGCGGGCACCCGGACCCCACCCCC

>NC_012669|12|11|4641576-4641701|CRISPRCasFinder
GACCAACCACACGGTCGATCCGCGGGCACCCAGACCCCACCCCC	CGACCGTGTAGTTCTTCCCCCACCGCCGGGCTTCGAGA
GACCAACCACACGGTCGATCCGCGGGCACCCGGACCCCACCCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012669.1\|WP_015884690.1\|4655925_4656867_+\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234948
NC_012669.1\|WP_015884679.1\|4639790_4640156_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NC_012669.1\|WP_083770196.1\|4654699_4655929_+\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NC_012669.1\|WP_015884682.1\|4643174_4644626_-\|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|131739
NC_012669.1\|WP_043347702.1\|4652374_4652959_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119344
NC_012669.1\|WP_015884676.1\|4633890_4634964_+\|inositol-3-phosphate-synthase	unknown	unknown	gnl\|CDD\|132491
NC_012669.1\|WP_015884671.1\|4625795_4626674_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012669.1\|WP_015884683.1\|4644758_4645283_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239645
NC_012669.1\|WP_015884672.1\|4626684_4627665_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_012669.1\|WP_050761780.1\|4627678_4629049_-\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NC_012669.1\|WP_015884675.1\|4633264_4633894_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367559
NC_012669.1\|WP_144017009.1\|4638449_4639688_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_012669.1\|WP_015884687.1\|4653066_4654101_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NC_012669.1\|WP_050761782.1\|4656869_4657376_-\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_015884677.1\|4635053_4637948_-\|cation-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319775
NC_012669.1\|WP_015884684.1\|4645321_4647433_+\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_015884688.1\|4654135_4654465_+\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NC_012669.1\|WP_015884680.1\|4640379_4641531_+\|hypothetical-protein	unknown	unknown	unknown
NC_012669.1\|WP_015884681.1\|4641788_4643102_-\|epoxide-hydrolase	unknown	unknown	gnl\|CDD\|377658
NC_012669.1\|WP_015884674.1\|4629162_4632999_-\|family-43-glycosylhydrolase	unknown	unknown	gnl\|CDD\|350094

Protein	Function_ID	Function_description	E-value
NC_012669.1\|WP_015884681.1\|4641788_4643102_-\|epoxide-hydrolase	gnl\|CDD\|377658	pfam06441, EHN, Epoxide hydrolase N-terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.	1.97787e-41
NC_012669.1\|WP_015884690.1\|4655925_4656867_+\|D-alanine--D-alanine-ligase	gnl\|CDD\|234948	PRK01372, ddl, D-alanine--D-alanine ligase; Reviewed.	5.21708e-88
NC_012669.1\|WP_015884679.1\|4639790_4640156_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	2.59563e-28
NC_012669.1\|WP_083770196.1\|4654699_4655929_+\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	3.74312e-123
NC_012669.1\|WP_043347702.1\|4652374_4652959_-\|hypothetical-protein	gnl\|CDD\|119344	cd06552, ASCH_yqfb_like, ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation.	2.95894e-07
NC_012669.1\|WP_015884676.1\|4633890_4634964_+\|inositol-3-phosphate-synthase	gnl\|CDD\|132491	TIGR03450, mycothiol_INO1, inositol 1-phosphate synthase, Actinobacterial type. This enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid.	0
NC_012669.1\|WP_015884671.1\|4625795_4626674_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	7.58132e-86
NC_012669.1\|WP_015884683.1\|4644758_4645283_+\|NUDIX-hydrolase	gnl\|CDD\|239645	cd03673, Ap6A_hydrolase, Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most preferred substrate, hydrolyzes to produce two ATP molecules, which is a novel hydrolysis mode for Ap6A. These results indicate that Ap6A hydrolase is a diadenosine polyphosphate hydrolase. It requires the presence of a divalent cation, such as Mn2+, Mg2+, Zn2+, and Co2+, for activity. Members of the Nudix superfamily are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site.	8.41655e-50
NC_012669.1\|WP_015884672.1\|4626684_4627665_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.08288e-81
NC_012669.1\|WP_050761780.1\|4627678_4629049_-\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	2.02497e-29
NC_012669.1\|WP_015884675.1\|4633264_4633894_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	2.65422e-13
NC_012669.1\|WP_144017009.1\|4638449_4639688_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.6727e-30
NC_012669.1\|WP_015884687.1\|4653066_4654101_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.60169e-153
NC_012669.1\|WP_015884677.1\|4635053_4637948_-\|cation-translocating-P-type-ATPase	gnl\|CDD\|319775	cd02080, P-type_ATPase_cation, P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase. This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_012669.1\|WP_015884688.1\|4654135_4654465_+\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	4.44737e-44
NC_012669.1\|WP_015884682.1\|4643174_4644626_-\|CCA-tRNA-nucleotidyltransferase	gnl\|CDD\|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	0
NC_012669.1\|WP_015884674.1\|4629162_4632999_-\|family-43-glycosylhydrolase	gnl\|CDD\|350094	cd08980, GH43_LbAraf43-like, Glycosyl hydrolase family 43 proteins such as Lactobacillus brevis alpha-L-arabinofuranosidase LbAraf43 and Geobacillus thermoleovorans GbtXyl43B. This glycosyl hydrolase family 43 (GH43) subgroup includes enzymes with beta-xylosidase (EC 3.2.1.37), alpha-L-arabinofuranosidase (EC 3.2.1.55) and possibly bifunctional xylosidase/arabinofuranosidase activities. In addition to Lactobacillus brevis alpha-L-arabinofuranosidase LbAraf43 and Geobacillus thermoleovorans IT-08 beta-xylosidase / exo-xylanase (GbtXyl43B). It belongs to the glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) which includes family 43 (GH43) and 62 (GH62) familiesGH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	2.09851e-105

>NC_012669.1|WP_015884680.1|4640379_4641531_+|hypothetical-protein
MTARSAPTDHPPTPAHDHPARGAVGHPAGTRATPDATRRLTGTALITSAVTTTLVGFFAAAPDLNPFLAEGNALGRALLPGPVLTWTLLAVALLGLATATAALLRPRSGDAGRLVAPVAALQVVAFGFLAQGAQTLSAAGYLMSLAVPVLVVWMAVQVFRTRPGWRIPIALGGVLAVVGIVVARDAFATQLGGVMSGFARERWGLLGVVIPLATATAWAGLALLRAWRRGSLHRATAWVTRHRRLFTVLAALGPLPYALARLTWLTPWAMFGGEGVPLSVKIQGLALSSGAWLGFFLTLGLILPWGERFPRWFPRRAGQPVPPAAAIIPGGIVAVMLSGAAIPLLLMMGASGAVLFPAWFWGPMLALAVWGYAGHRAGIDVSR
>NC_012669.1|WP_015884679.1|4639790_4640156_-|VOC-family-protein
MTEKSARRWIDYVELTVTDLPAAIAFYERAFGWEFTSYGEGYAGIRGATSDDPEVGGLSLGDSVRPGGPFLLFSSDDLDASVVAVTDAGGAVVQGPYSFPGGRRFHFTDPSGNELGVYQDD
>NC_012669.1|WP_144017009.1|4638449_4639688_+|MFS-transporter
MFQVGLASLLFFSPESQGTAAAIAGAFAVMLAPFTIVGPFAGVLLDRWQRRQVLVWGNAVRVVLTLGMAALMLAGGVSGWIYAVGLAALSVNRFLLAGLSAGLPRVVDRPLLLTANSITPTLGAGAAFVGGGIGFVLGLAFEPGRVKDSSALVCAAVVFAVASLLALRLGRTQLGPDRPAEASVHSEIAKVARGLVDGARYLAARRTPGQALLAMATHRFLYGVVFIASILIARNLLDPGNQDAGLATFAVVVGLTGAGGAVAMVLTPTLSRHTGPQAWIAIMLLLAAASQLLLVTTPSRAVVYAGAGLLGLAAQGTKIAVDTIVQRDTEDSYRGRAFAFYDVLYNAAFVGAAALAAFTLPDTGWSRAVFVALAVAYALAALVMWTRGARSPRPVGSAEVSDVGPSSTTLPA
>NC_012669.1|WP_015884677.1|4635053_4637948_-|cation-translocating-P-type-ATPase
MEPAEHAPTPSTPRPSGPGPRPAPSVAAGTTSTAPDPSTRDAADVARDLGVDLDVGLSRAEAARRLAENGPNDLRETLPVPLWRRVLAQFQDPLVYLLLVAVAISLVAWIVEGAEGLPIDSVVILAIVILNAVLGYVQEQRAESAVAALRDMTAATSTVLRDGELRTVASAELVTGDVLVLAEGDAVGADARLFAATALRVSESSLTGESEAVTKNTRTLPEPAPLGDRLDMVFRGTAVAQGVGRAVVTSTGMGTQMGAIAEMLEATEADPTPLQREISSVSKLLGITVIAIAVVVMVTIALVNQVDELSDAVTVLLLGVSLAVAAVPEGLPAILSVVLAIGVQRLARRNAVVKKLSSVETLGSASVICSDKTGTLTKNEMTIECIVTASGRVDLTGVGYRPDGVALHKGHRLEDSRLAREARIALGGGMLANEAQLLERDGEWQIQGDPTEAAFLVAARKLDRTIEEAAHYERQGSVPFTSERKRMSVLGRRDTDGQLVLISKGAPDVLLSFCTHVVVGEDVVELDDARRERILADVEGLSAQAFRTLAVAYRPADDLEPADGSADLDESAEHDLVYVGVVGIIDPPRDEVALAVREAHRAGIRVVMITGDHPATAARIAADLGIVEPGAEALTGRELDAIDDDELTLVVRRVSIYARVAPEHKLRIVDALQADGLVVAMTGDGVNDAPALKSADIGVAMGITGTEVTKEAGDMILGDDNFATIVAAVRQGRVIFDNIRKFLRYLLSSNMGEVLTVFLGVVLAGVIGLAGASDEHVVLPLLATQILWINLVTDSGPALAMGVDPEIDDVMARRPRALTDRIIDGRMWSGVISIGLVMAVATLVTIDVFLPGGLIDGTDTLDVARTAGFTTLVLAQLFNALNSRSETTTAFHRLFVNRWLWGALALGVVLQVAVVEVPVLQHAFGTASLDLAHWGVCVALASAVLWFDELRKWVWRVRHPEVPA
>NC_012669.1|WP_015884676.1|4633890_4634964_+|inositol-3-phosphate-synthase
MSSIRVAIAGVGNCASSLVQGVHYYRDADPNGSVPGLMHVQFGEYHVGDLEFVAAFDVDAKKVGFDLSEAINASENNTIKIADVPPLDVPVQRGPTLDGLGKYYRETITEASGDAVDVAQALRDARADVLVCYLPVGSENAAKHYAQAAIDAGVAFVNALPVFIAGTPEWAEKFRAAGVPIVGDDIKSQVGATITHRVLARLFQDRGVVLDRTYQLNVGGNMDFKNMLERDRLESKKISKTQAVTSNIDHDLGSRNVHIGPSDYVQWLDDRKWAYVRLEGRAFGEAPLNLEYKLEVWDSPNSAGIIIDAVRAAKIAKDRGIGGPILSASSYFMKSPPEQYPDDLARAKVEAFIAGEA
>NC_012669.1|WP_015884675.1|4633264_4633894_+|helix-turn-helix-transcriptional-regulator
MRNRGDVLELAILGRLADGPLHGYELRKRLGVVLGAFRTLSFGSLYPRLRALEEKGWIRPVDTAALPHALAGRRSRVVYELTADGKERLAGALSRAEPASWDDETFDVRFSMFGETDPETRLRILEGRRTRVLERREAYRSAGTRGRERRDTYTLELQRHGLELLDREVSWLEDLIAKERSGTTDHPASDTPQTPDGRPAGREPEKENP
>NC_012669.1|WP_015884674.1|4629162_4632999_-|family-43-glycosylhydrolase
MTRVSTPLAAFVAALAFLVCGLVAPPAAADDGLVVYVDADAGDDAAPGTSPDAPVRSLAAALDLVAGDGGRVVLMGDYPLDATFVEPSHTEPILVTSTDGEQAYPGRLVFGDTPFIEYNLAGPTTFADLTVVTSQWSVFAANWHPITFGDGVEMVSVPTAGVRQVFVVGGYHGPSAEDTVLDADSHITISSGTFYKVAGFSRGKGVGTQTYTGTSHITIDGGVVQEVFGASLENHYSGSTEITMTDGRVGALHTAGDVTRYIVGSATVTLTGGHINTIDINNVVEDVNLTLDGVEWDAIQAANAWGGEGRHQQILEFAPVRTVRFAGQHYTPEQVAALREIFDVLVNTADVHVSADGEGSACSAASPCGSLETALGLLAAEGGAITVSGDVTWDVDPATLAAGAGRVTFAGDGAASIAFAADAEVLIARDVRFSSLELANAGSLELQADGADLVIGDGVTTDRGRQVSVVGVSDDSSITIGSGEFARVVGITGLTDDFEGTTDVTIAGGEVRHVWAGTDEPFDVAGALVTIAGGEVRTLHSSAGRVTESLTARFLAGEVRNARLDRADGDVSVRLGDAEIDRISVSDWAAVDGAERSLVRLPGADEDVIDEIAGSFDGVTEDEVVYLAADGDGDGSSPTHAVGDLSAAIAALSGDGRVVLTDRYTIEGGYDLGAYGSRVALTSDDGDIDFAADGAALQIEGAMRLGGPTTVENLLLQSPTVDGTIYAMGHPLTIGTGVDTEFTRRGETYLTIVGGRDDAVPAPATSVTVEGGPWAGLRGGSDNTGAVTPGAEVALQIDGGTFYGPVVLAHRGESSGSASATISGGTFTQGVYAVYEEDGSAYTADYDADITVSGGEFWATIAPAKSRSTELAGTFDLTVSGGEFGHLTDLLGSEGFAGDMVSSLHIDPAIAQAVPEGELTFTNPIVRAADPYMFTHEGQYYFLATSGTTMSLYKVANPSDLSQAVGSVIFAPDDMANLWSPEIHYLAPEEVGEQDAGWYLYLSAAQLGDGAAEGQRQYVLKALDGDDLFGRWGDPVTGDVNVARRITNVDDPDFNAESFVAGISLMRVAGDTYITYVDEVGRGTSEFHQRILMSRIVNPWTLRGAPTVITRSEYDWEMHGYAQSDSDPNMWWPKVVEGATAVYGHDGEVYMAYSASGYWTVYYAIGYLRYVGGDPMVASNWVKNPTPIMSKNAEVTGTGTGPNFADHEGTDWFMFQARPGPNTQTARYAFIEPYVADADGLTIGDGSGHPAPLETTYTMSVNPIPLGDKISGFTPSDG
>NC_012669.1|WP_050761780.1|4627678_4629049_-|carbohydrate-ABC-transporter-substrate-binding-protein
MTVVNGNWQLSRRGLLGGGLGLAAGAGMLAACGPSDGSGGSDGEPPEDLGSPEEGRLVVWGGVAPETGPQALVDAFMAKYPDIEVEYTRYVNDEEGILKLDTALQGGVPIDVYFSYGTVDVVRRSQAALALDLTDLAREDDLAQIFVQDEPISTLVDGKLFSIPTTHFPNFVVINQDAMEAAGIEIPFDWTVDDYHQIAQEFASAGFDVGAYNVPRHEAVGLGGDYLYTEDGTESNLDHPLVRERLEATLAMEDDGSIFTQERITAEGIGGYAQNYFLDGTFAMMLDGTIIARYVKNLEEYPHDFRTTFRPYPRLAAGEPYINPGVRGDDVQISAKSKYASAAWTFVKFWMGEGAELVTPSGKVSPFQYEDGPSDSLNEALFGPDADELFDVESFEQTFFAAEPPLAVRSITTAFTEISSIKSQIEEEIRLRTKSIDDGIAEMKTLADEAIDSWLE
>NC_012669.1|WP_015884672.1|4626684_4627665_-|sugar-ABC-transporter-permease
MTLISEGAKPDRAGKLPRGSAPSTPDRPQRSVLVNGYRWWIPWLFVIPTVLCVLAFLVVPMVSGLFIAFTDWDVVSGLGGIRWIGLGNFQELVQDDMFWSSALRTLFYAGVGTPLTITVGLFLGLALNRPMPARGVIRAIFFLPSLVNVIAAGTVWLTLLNPTSGMVNQFLRALGLTDVPGWFTSEQWALPAIVLMSVWISAGYVAILIIAALQDLPPELYESAKLDGAGTTRQFTAITLPGLVPILTFLLITSFIGRSQGFGLIQFMTGGGPGDSTTVLSYYMYEVGFHWYRFGYAAAIGVMSMLAVLALSIALFKLQRGRGLYT
>NC_012669.1|WP_015884671.1|4625795_4626674_-|carbohydrate-ABC-transporter-permease
MSADAARYAPRPSLVKRQRRERASWIGRGVVMSLLAIVFLIPFLWMVSSSLKQNLDIFEIPIRWIPNPVDWSNYVDVWTGERSMVRYFSNSTIVVVATIIGELAVVTLAGYAFGQLRFKGQNVLFIAFLATSMVPAQLMLVPRFMFFRELGLYDTLWALILPGLASVFATFLLRQHFASAPRELGEAARIDGAGEGRIFWSIYLPMARPALAALAILIFDSTWNDYESALIMITDEAKYTVPLGLTRFMSEDGTVSMGPAMAGSVSSLIPVLVIFLIFQRHFLRSMARVGLR
>NC_012669.1|WP_015884681.1|4641788_4643102_-|epoxide-hydrolase
MEFRELTIDVPQAVLDDLTERLARTRWPNEPTGGEAGGLGEVRRLVSHWAEHYDWSEVQDRLNRWTHRVARVDGRDVHVVHERSAAPGAVPLLLLHGWPDSFYRFAHVVDRLTRRDGDDDDGPAFDVVVPSLPGYVFSEQPEPGGATLAAVAETIAQVMAGLGYERYVVHGGDWGAAIAQEIARAHPERVLGLHLTDVPFPNMFTVDRESATDAERAYLGASMAWAESASYFTVQSGAPLELAYGLSDSPVGLAGWLGDKFRAWSQAPLADDDVLTNVMLYWVTNTVRSSFRFYAEGLGGEWDSGDAAEWGGSAESGGVAESGGAAESGGSGGWGGDAAGYGSVGSGEWGGDAAGSGSGDDAGAAAADWSPRIEVPTAIALFPADLGGPAPREYVERFFDVRRYTLMPRGGHFAALEEPALLVDDLRAFAAQLAEAR
>NC_012669.1|WP_015884682.1|4643174_4644626_-|CCA-tRNA-nucleotidyltransferase
MPTPEAQRPAQLMRTALGVLAGIAADVDPLGDLFAAGGHEIALVGGPVRDAFLGRGSSDLDFATSARPEQTEAILARWGDAVWDVGRAFGTIGAGRGDVVVEVTTYRTEAYDAGSRKPAVEYGDTLDGDLSRRDFTINAMAVRLPDLTFVDPHHGLDDLAAHVLRTPVSAEQSFDDDPLRMMRAARFAAQLRVDVAPDVMAAMTAMAGRLAIVSAERVQAELTKLLLAPAPRRGLELMVETGLADVVLPELPAMKLEIDEHHRHKDVYEHSLTVLDQAIDLETGPDGPVPAPDLVLRLAALLHDVGKPATRRNEPGGRVSFHHHEVVGAKLARKRLAALRYDKATIADVTTLIALHLRFHGYGDGAWTDSAVRRYVTDAGPELERLHRLTRADCTTRNRRKAERLSHAYDDLERRIAELAEKEELAAIRPDLDGAAIMATLGIGPGPVVGEAYRFLLELRMERGPVEPDVARAELLAWWAARE
>NC_012669.1|WP_015884683.1|4644758_4645283_+|NUDIX-hydrolase
MSSQSPAQPAAGRPAPPTVRLERPTAALPVVDETSAGGLVVDVVDGAAYTAVIARRNRAGRLEWCLPKGHLEGAETAEQAAVREIAEETGITSQVLRHLATIDYWFAGHDRRVHKVVHHYLLEATGGELTTENDPDHEAEDVAWVRLDEVSARLAYPNERRIVATARDLLAGPL
>NC_012669.1|WP_015884684.1|4645321_4647433_+|hypothetical-protein
MAAALVALLGLGGAALATTPAVADEAGGVSVEITDLLPAVALPDDELVIRGTVENTADSVLEDPTVSLRVQWRTPNWRTALELWLDPEGGVASRNVVTQPLDGDLAPGDRVPFEIRIPVEEAGVAATESSWGARGLEVRAGDATRSASDRTVGVFYPDTDPLPAPTELSVLLPLAPDASEWEAARAEERPVGDVAAERLTELAGLGGPDVSWALDPSVLASDPLPAEPDDDPTAPATDGTGGTTDPPSGTEAPTDGGADDDGAAADGADAVADLTRTLRTASAGRDVVALPYGDADSGNVIRAGQPSLLAQARERGAGLTDEADLRVLADVAWPAGGELDQQVADGLADAGYDTLVMPSSLVAPTTPITYTPTGRASLPASDGTTLDAALWDPELSTALGGAGTDELTSRQLLLGLTAVIARERPLDARGLLAVVDREAMADADLDALAERLEALEQAPWLDVVPLRSLLGRPDEALDRAALPAEGDPLDDGTELTLARTAAELTRADGVATALADPEPVLRGVRDDLLSVSSTAWRGRPEGRLATLEDATAALDDVLSGIGVTPPGSHINLIAQEGSIPIDVTNALDQEVTVTVVLSSSDPVLVVEDTPQLTLPPADGGTPSVTTVRVPVHGVKNGDVDVQVELRTPSGTVVGEEASFAIRVRADWETVGTAVVAGILGLLLVIGLYRTIRRGPRKATGEPS
>NC_012669.1|WP_043347702.1|4652374_4652959_-|hypothetical-protein
MLFETRFADGVRSGAVTVTFRRWRRVQAVAGHRYRTAVGRIVVDDVGVVDVTRIGDDDARLAGYADAPELVADLRGAPDLPVYRVAFHADPEPDERDVLAASDGLTDADVAEIDRRLDRLDRASSHGPWTRQTLTLIAAHPARRAPDLAAMLGRERDPFKVDVRKLKNLGLTLSLEVGYRLSPRGKAYLRSTRV
>NC_012669.1|WP_015884687.1|4653066_4654101_+|thioredoxin-disulfide-reductase
MPQDAQVREVIIVGSGPAGYTAAVYAARADLRPLVFAGSVTAGGALMNTTDVENFPGFPDGVLGPELMEKLSAQAERFGAEIVYDDIESVDLAGEIKTVTNADGETFRARSVILATGSAYKELGLPEEKRLSGRGISWCATCDGFFFRDQHIVVVGGGDSAMEEATFLTRFASKVTLVHRRGELRASKIMAARAEADPKIEFAWHSEVAAIHGDDKVTGVRLRDTRTGEERELDATGVFVAIGHLPRTELVSGQIDLNAEGYIEVTHPTTATNLPGVFAAGDAVDHIYRQAITAAGTGCAAALDAERYLAALGEAGDPDRDAAQTPDPDGHVVAADATPAVVVG
>NC_012669.1|WP_015884688.1|4654135_4654465_+|thioredoxin
MSTVTAVTDDTFATDVLQADGVVLVDFWAPWCGPCRQVAPVLEDIANELDGQVTVVKVNTDENPSTTAAYGIVSIPTLNVYSGGELVKSLVGARPKKAILAELEQLLPA
>NC_012669.1|WP_083770196.1|4654699_4655929_+|PLP-dependent-aminotransferase-family-protein
MRASEIRALFSVANRPEVVSLAGGMPNIAGLPMDRIAEETQRLLAERGAVALQYGSGQGEPGLREQITEVMALEGMNAHPDDVVVTTGSQQALDLVARIFLDPGDVVVAEAPSYVGALGVFRAYEADVVHTPMDADGLVPDALDATLTRLAAEGRRAKFLYTVPNFHNPAGVTLSAERRPRIVEIARRHGVLILEDNPYGLLGFDSDPLPALASLAPEGVVYLGSFSKTFAPGYRVGWALAPHAVRDRLVLASESSILCPSMMSQLSIATYLSTSDWRGQIKSYRQMYAERRDAMVAALAEHLPDCTWTTPDGGFYTWLRLPDGLDAREMLPRAVTALVAYVPGTAFYADGSGADHMRLSYCYPTPERITEGVRRLAGVVSAEQELVTMFGTSDARGGRTLDAPGPEQP
>NC_012669.1|WP_015884690.1|4655925_4656867_+|D-alanine--D-alanine-ligase
MSFDVLVLAGGLSHERDVSLRSGRRVAEALRDAGVSAAVRDVDADLLAYLDDARPDVVWPLLHGSTGEDGSIRDLLELVGVRAVGTGSAGSRIAWAKPVAKTVLARAGVATPASATLPQSLFRELGPHAVLGRVLDRLGLPLVVKPASGGSALGVSLVTSAEALPQAMVSCFSYGDVALIEQAVTGTEVAVSVVDLGDGPVALPPVEIVVDDGPYDFDARYNAGRTEYFTPARLPADHLAAACAVAVRAHDVLRLRHLSRTDLVVDGYGVAWFLEVNVAPGMTETSLFPLAAAASPTPLPELYRGLADVARRG
>NC_012669.1|WP_050761782.1|4656869_4657376_-|hypothetical-protein
MRAWIVRLGALLVFNLIVVVAIVLFVPGVRGSWGVLWAAVVLTAATVWVKPLITSFLTDQAGNWAGRPRWLAGKVLTYAIVYVVAFVIWLLTVILSDVNVHGWFLGYVLPPLIVIVGWFVYDMVDDRFEATAGNAYDAAHRRMTGGSSTEASAERPADPSEGPAGPRP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_012669_2	2.1\|490513\|18\|NC_012669\|CRISPRCasFinder	490513-490530	18	NC_012669.1	490585-490602	0	1.0
NC_012669_2	2.2\|490554\|17\|NC_012669\|CRISPRCasFinder	490554-490570	17	NC_012669.1	4103529-4103545	0	1.0
NC_012669_2	2.1\|490513\|18\|NC_012669\|CRISPRCasFinder	490513-490530	18	NC_012669.1	1977190-1977207	1	0.944
NC_012669_2	2.2\|490554\|17\|NC_012669\|CRISPRCasFinder	490554-490570	17	NC_012669.1	764422-764438	1	0.941
NC_012669_2	2.2\|490554\|17\|NC_012669\|CRISPRCasFinder	490554-490570	17	NC_012669.1	3470233-3470249	1	0.941

1. spacer 2.1|490513|18|NC_012669|CRISPRCasFinder matches to position: 490585-490602, mismatch: 0, identity: 1.0

ggcggggggtgcgggctg	CRISPR spacer
ggcggggggtgcgggctg	Protospacer
******************

2. spacer 2.2|490554|17|NC_012669|CRISPRCasFinder matches to position: 4103529-4103545, mismatch: 0, identity: 1.0

ccggcgcctgcggtgcg	CRISPR spacer
ccggcgcctgcggtgcg	Protospacer
*****************

3. spacer 2.1|490513|18|NC_012669|CRISPRCasFinder matches to position: 1977190-1977207, mismatch: 1, identity: 0.944

ggcggggggtgcgggctg	CRISPR spacer
ggcggagggtgcgggctg	Protospacer
*****.************

4. spacer 2.2|490554|17|NC_012669|CRISPRCasFinder matches to position: 764422-764438, mismatch: 1, identity: 0.941

ccggcgcctgcggtgcg	CRISPR spacer
ccggcggctgcggtgcg	Protospacer
****** **********

5. spacer 2.2|490554|17|NC_012669|CRISPRCasFinder matches to position: 3470233-3470249, mismatch: 1, identity: 0.941

ccggcgcctgcggtgcg	CRISPR spacer
ccggcgccggcggtgcg	Protospacer
******** ********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_012669_5	5.1\|1723246\|26\|NC_012669\|CRISPRCasFinder	1723246-1723271	26	NZ_CP033045	Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence	536798-536823	5	0.808
NC_012669_5	5.1\|1723246\|26\|NC_012669\|CRISPRCasFinder	1723246-1723271	26	NZ_CP025584	Paracoccus jeotgali strain CBA4604 plasmid pCBA4604-01, complete sequence	87009-87034	5	0.808

1. spacer 5.1|1723246|26|NC_012669|CRISPRCasFinder matches to NZ_CP033045 (Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.808

ctcccggagaacacggttcttccgtc	CRISPR spacer
atcccggagaacaaggttcttgcgga	Protospacer
 ************ ******* **

2. spacer 5.1|1723246|26|NC_012669|CRISPRCasFinder matches to NZ_CP025584 (Paracoccus jeotgali strain CBA4604 plasmid pCBA4604-01, complete sequence) position: , mismatch: 5, identity: 0.808

ctcccggagaacacggttcttccgtc	CRISPR spacer
aatccggataacccggttcttccgtc	Protospacer
  .***** *** *************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage