CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_013037	Dyadobacter fermentans DSM 18053, complete sequence	9 crisprs	WYL,DEDDh,csa3,cas3,PD-DExK,Cas9_archaeal	1	1	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_013037_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013037_1

563089-563786

Orphan

Consensus_repeat	Method
ATGGGCTGGTTAAATGCACTTGC	CRISPRCasFinder

9 spacers

The CRISPR arrays of NC_013037_1

>merge|NC_013037|1|563089-563786|CRISPRCasFinder
AACGACTGGTTGAAAGCGCTGGCGCCATTGAACATATTTTCCATTGTCCATACCCAACCGATGTTCCAACCGCTGATATCCTGGTTAAATGCGCTTGCTCCATAAAACATATATTCCATTTGCTCCACATACTGCGTATTCCAGCCGCCGATGTCCTGGTTGAATGCGGTGGCGCCATCAAACATGTGTGCCATAGTACTCACACCGCCGACGTTCCAGGTGCCGATGGGTTGGTTAAAGGCAATGGCACCGGCAAACATATTGTCCATTTGCCACACCGATTCGGTATTCCACGTGCCGATGGGTTGATTAAATGCGCTGGCGCCGTTAAACATACCAGACATTAAATTCACTTTCTGAGTATTCCACGCACCGATGGGCTGGTTAAATGCACTTGCACCTTTGAATATATTATATATTAATGTCACATTCCCGGTATCCCAGGTGCCAATGGGCTGGTTAAATGCGCTTGCGTCTTCAAATGCAGAACTCATATCTGTTACTTGCCGGGTGTTCCAGTTACCAATCGGTTGGTTAAATGCGCTGGCGCCCTTGAATATGGCATTGATGTTGCCTGTATTTTGAATATTCCAGGTGTCAACGGGCTGGTTAAAAGCCCTCGCGTCCTGAAACATGCTCACCATGGTGCTTACATTGGCGGTGTTCCAGTTATTGATATTCTGGTTAAACGCGCTGGC

>NC_013037|1|1|563089-563786|CRISPRCasFinder
AACGACTGGTTGAAAGCGCTGGC	GCCATTGAACATATTTTCCATTGTCCATACCCAACCGATGTTCCAACCGCTG
ATATCCTGGTTAAATGCGCTTGC	TCCATAAAACATATATTCCATTTGCTCCACATACTGCGTATTCCAGCCGCCG
ATGTCCTGGTTGAATGCGGTGGC	GCCATCAAACATGTGTGCCATAGTACTCACACCGCCGACGTTCCAGGTGCCG
ATGGGTTGGTTAAAGGCAATGGC	ACCGGCAAACATATTGTCCATTTGCCACACCGATTCGGTATTCCACGTGCCG
ATGGGTTGATTAAATGCGCTGGC	GCCGTTAAACATACCAGACATTAAATTCACTTTCTGAGTATTCCACGCACCG
ATGGGCTGGTTAAATGCACTTGC	ACCTTTGAATATATTATATATTAATGTCACATTCCCGGTATCCCAGGTGCCA
ATGGGCTGGTTAAATGCGCTTGC	GTCTTCAAATGCAGAACTCATATCTGTTACTTGCCGGGTGTTCCAGTTACCA
ATCGGTTGGTTAAATGCGCTGGC	GCCCTTGAATATGGCATTGATGTTGCCTGTATTTTGAATATTCCAGGTGTCA
ACGGGCTGGTTAAAAGCCCTCGC	GTCCTGAAACATGCTCACCATGGTGCTTACATTGGCGGTGTTCCAGTTATTG
ATATTCTGGTTAAACGCGCTGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013037.1\|WP_143828634.1\|570443_570953_-\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_012780128.1\|573580_574312_-\|FRG-domain-containing-protein	unknown	unknown	gnl\|CDD\|378073
NC_013037.1\|WP_012780122.1\|569507_570407_-\|response-regulator	unknown	unknown	gnl\|CDD\|381108
NC_013037.1\|WP_012780126.1\|572329_572848_-\|DUF4142-domain-containing-protein	unknown	unknown	gnl\|CDD\|379301
NC_013037.1\|WP_012780112.1\|554523_556164_+\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|377164
NC_013037.1\|WP_187293420.1\|572941_573454_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_012780121.1\|568130_568796_+\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|132880
NC_013037.1\|WP_012780111.1\|554234_554534_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_143828633.1\|556569_557010_+\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|377965
NC_013037.1\|WP_143828873.1\|571234_572260_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235935
NC_013037.1\|WP_012780114.1\|557075_559262_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_012780118.1\|561713_562262_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|226075
NC_013037.1\|WP_012780117.1\|560518_561541_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225052
NC_013037.1\|WP_012780120.1\|567308_567677_+\|glyoxalase/bleomycin-resistance/dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|319925
NC_013037.1\|WP_012780116.1\|560015_560462_-\|SRPBCC-domain-containing-protein	unknown	unknown	gnl\|CDD\|176856
NC_013037.1\|WP_012780115.1\|559263_560013_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_012780124.1\|571010_571238_-\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_143828872.1\|553937_554228_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_041735735.1\|553066_553633_+\|DUF4256-domain-containing-protein	unknown	unknown	gnl\|CDD\|339073
NC_013037.1\|WP_012780129.1\|574308_575184_-\|cyanophycinase	unknown	unknown	gnl\|CDD\|131124

Protein	Function_ID	Function_description	E-value
NC_013037.1\|WP_012780128.1\|573580_574312_-\|FRG-domain-containing-protein	gnl\|CDD\|378073	pfam08867, FRG, FRG domain. This presumed domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterized.	9.78001e-30
NC_013037.1\|WP_012780112.1\|554523_556164_+\|PepSY-domain-containing-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	4.68262e-49
NC_013037.1\|WP_012780121.1\|568130_568796_+\|DNA-alkylation-repair-protein	gnl\|CDD\|132880	cd06561, AlkD_like, A new structural DNA glycosylase. This domain represents a new and uncharacterized structural superfamily of DNA glycosylases that form an alpha-alpha superhelix fold that are not belong to the identified five structural DNA glycosylase superfamilies (UDG, AAG/MNPG, MutM/Fpg and helix-hairpin-helix). DNA glycosylases removing alkylated base residues have been identified in all organisms investigated and may be universally present in nature. DNA glycosylases catalyze the first step in Base Excision Repair (BER) pathway by cleaving damaged DNA bases within double strand DNA to produce an abasic site. The resulting abasic site is further processed by AP endonuclease, phosphodiesterase, DNA polymerases, and DNA ligase functions to restore the DNA to an undamaged state. All glycosylase examined to date utilize a similar strategy for binding DNA and base flipping despite their structural diversity.	1.29749e-13
NC_013037.1\|WP_012780117.1\|560518_561541_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|225052	COG2141, COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion].	2.60152e-37
NC_013037.1\|WP_143828633.1\|556569_557010_+\|SH3-domain-containing-protein	gnl\|CDD\|377965	pfam08239, SH3_3, Bacterial SH3 domain.	3.9554e-05
NC_013037.1\|WP_143828873.1\|571234_572260_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235935	PRK07109, PRK07109, short chain dehydrogenase; Provisional.	1.5818e-75
NC_013037.1\|WP_012780122.1\|569507_570407_-\|response-regulator	gnl\|CDD\|381108	cd17557, REC_Rcp-like, phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains. This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.40785e-29
NC_013037.1\|WP_012780118.1\|561713_562262_+\|alpha/beta-hydrolase	gnl\|CDD\|226075	COG3545, COG3545, Predicted esterase of the alpha/beta hydrolase fold [General function prediction only].	1.79059e-05
NC_013037.1\|WP_012780120.1\|567308_567677_+\|glyoxalase/bleomycin-resistance/dioxygenase-family-protein	gnl\|CDD\|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.30135e-05
NC_013037.1\|WP_012780116.1\|560015_560462_-\|SRPBCC-domain-containing-protein	gnl\|CDD\|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	2.51565e-05
NC_013037.1\|WP_012780126.1\|572329_572848_-\|DUF4142-domain-containing-protein	gnl\|CDD\|379301	pfam13628, DUF4142, Domain of unknown function (DUF4142). This is a bacterial family of unknown function.	7.32117e-45
NC_013037.1\|WP_041735735.1\|553066_553633_+\|DUF4256-domain-containing-protein	gnl\|CDD\|339073	pfam14066, DUF4256, Protein of unknown function (DUF4256). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 190 amino acids in length.	2.86727e-131
NC_013037.1\|WP_012780129.1\|574308_575184_-\|cyanophycinase	gnl\|CDD\|131124	TIGR02069, cyanophycinase, cyanophycinase. This model describes both cytosolic and extracellular cyanophycinases. The former are part of a system in many Cyanobacteria and a few other species of generating and later utilizing a storage polymer for nitrogen, carbon, and energy, called cyanophycin. The latter are found in species such as Pseudomonas anguilliseptica that can use external cyanophycin. The polymer has a backbone of L-aspartic acid, with most Asp side chain carboxyl groups attached to L-arginine. [Energy metabolism, Other].	4.24674e-57

>NC_013037.1|WP_012780118.1|561713_562262_+|alpha/beta-hydrolase
MERQIIFLQGGGSKEDYEADQPLVDSLREHLVPGYDIHYPLLPDDGTPDLGRRSQIAAHIAASSDGVLLVAHSFGASMLLACLSEIEIQRKIGGIFLISTPFWEGNEDWVEPFKLRADFAGKLDRTIPLFFYHCLDDEEVPVEQLSVYEQELPWATFRKIPTGGHQLNNDLGIVAQDILAPI
>NC_013037.1|WP_012780117.1|560518_561541_-|LLM-class-flavin-dependent-oxidoreductase
MKKIGFLSFGHWSNHPAYNARTASDTLLQSIDLAVAAEEIGLDGAYFRVHHFAAQLASPFPLLAAIGAKTSKIEIGTGVIDMRYENPLYMVEDAGAADLISEGRLQLGISRGSPEQVIDGWRYFGYEPEQGETDADMGRRKALEFLERLNGVGFAEPNPYPMFPNPPGLLRVEPHSEGLRERIWWGAGSNATAVWAAENGMYLQSSTLKNDEGGKPFHVQQAEQIRLYKEAWKKAGHQREPRVSVSRSIFALVTDQDHRFFGQEAGRTDKIGTIEPGKRAIFGRSYAAEPDQLVKELAQDEAIQEADTLLLTIPNTLGVDYNIHVLSSILKYVAPGLGWR
>NC_013037.1|WP_012780116.1|560015_560462_-|SRPBCC-domain-containing-protein
MSRKLVQKDIHIQASAEQIWRIITEDEHNVKWLAAFGEGNIAQTDWQEGSKARFTDDSNVGLIAVIRESRPFEKILIQNIGILTDGKEDYDSDEAIESQEFFEQYLLTPEDNGVRMQVQVNVEDEFYDEISDCWERALGIMKGQAEGG
>NC_013037.1|WP_012780115.1|559263_560013_+|hypothetical-protein
MDGLQSFLEIGAFIIAALTLYKAISEYSKNNVFKRASVLEELIVKFKKPELFAAKRLLDDFQEYHYKGMSSGAQYDPTQVSDPVIFVHANYKSQKCVAERIEKGKDIFRIFIDKDLPIEKTPGPDTSVFYANQNFPGAHKYVFINLAYLLRNHESDIINDNEIFFRDSFDELLDFTLLLIYYLRNEIITIREVQAHFAFYLKKVKHSKPVLQYISIYYNSEDFDWLFRQLPSKADSILYTDWSSDELEE
>NC_013037.1|WP_012780114.1|557075_559262_+|hypothetical-protein
MTNFLYNVMMRILNRFGIRVGRSFAQQLFRSFWTVARHVILLFVLILVYAIILFSNPQGIDIVNEVIKNSRYWVWTMLSLFAFSMSLWFCATLLFQLKQISHDRAFIKANAAGMMFWLVVLPIFLSSLPFVLLLFKPDLYSENAYPLIIVIGFVLFVLPLVLTEFFRLLKLTFQNVRWFHGISAQKQTLKSLLFFRGTRMLFYFFLAYTIILFILSLTSVETGFAVKVGPIAVMVFGLSFLSMVFSTLMYFNIPGRRPFLLYCVILIAIFSAINDNSHIRTLPKTVARPPLESDFEKWAIELPNKDSLISLPDTILAPPESNASKKPEKQPIPIFFVAAEGGGIRALSWTALVLASLEKKYPGIHWHIYGISGASGGGVGATFYMYYLHDQLAAKTDPVLYEASFRRSIRNDFLSDVLAACMFQDNLQNILPIGVPSFDRTRRLEDAWSKAFTYHTNSDSFESGFLSLYADTTLRLPRLFLNGVLAETGQKTIVTYPLLHSAPAPDINEPDVLKDELDVIASIGKDIPVKTVASLCSRFPYITSGGLISSSGGKKIGHVIDGGYKENTGLETVWQLLLRLKPVIIKVENSALFKQNGIRLKPVVIFVKNSPATDVLDEKTKIAGMLHEISMPIIGFMNASDRKTPTIDALTENVFKYYNDKNSDLLPCEYIRIDLDRSSKQGFNLPLGWYFSDGSFAYVDQKLKESFQDSSAFSKKIGAYTKQIFKIK
>NC_013037.1|WP_143828633.1|556569_557010_+|SH3-domain-containing-protein
MSDRLLSNGLISKTWLSMSMGFRGTKEAIRKGNYQLLQRAPATTLCGLGVDFNEANPVDPDFGAFTIDDDPVDGALEPVLQNRYIVIARNGLRLREGPGTQFEVIGSMRPGQVIFATITIDGWARVDVEGDGLIDGFASADFLQRT
>NC_013037.1|WP_012780112.1|554523_556164_+|PepSY-domain-containing-protein
MDPRKYNIYFHTHTISGIIIAALLYVIFFAGSFSFFKDDIAAWQKGRSEVARDFDPPYNHLLDSLSQHYNLRGRNFNFYLLRQGQGSYVDMSVSQDTTVSKPKPKPQKEERRRGRGRRDNDDSAYFRYHFSDKKAGDYSDSYDMAEFLYRLHFLAQLNQVGINIGTPFGYLVAGIVAFLFLFALITGLLLHWDKIKTNFFLFRPMSKWKTVWTDMHTVLGVIGFPFQLIFAVTGVVLIVNYVLLTPFANLLYNGDSDKLYESLQYNRSVKVDYTYKPMNGTFDMDAMVARWQNEWKDSQITRIYIRNYMDESMQVSLEAKPNPNANFAGSGYATVHVPSGKVLEEKSPNAGGNYIDTVKSLVYHLHFGDFGGTPLRIVFFLLGLMGCAVIISGIMIWLVARDKVATELRKRKFNFWASNFFLSACLSMLPVTAFTFIMIKTLTHVDQSVIYNTYFYSWLVLGIYLMALRNLPQMNRHTLLLSAVLCTGVPIANGMATGLWMWTTWSQGAFDIFFIDALFLVLAGCSAYAYTRVNVQAKPFQVLGRA
>NC_013037.1|WP_012780111.1|554234_554534_+|hypothetical-protein
MPANKKYLTKSPRLRLSKILAGSVGGYAVTMSLHLFFTTFLPKENVIITAYFTGYILWACLLLYAFVATNVWRVWGLYILLTVVFALPYLLKFNLNHGS
>NC_013037.1|WP_143828872.1|553937_554228_+|hypothetical-protein
MFWMNTSTRVSWPDKNRLMVSVASNPLYSRVMAGALFLAGTALCVASLGLGSGLFAAVVILMTAGSVSVLFFPFRYFGSGAVAILYLCAVTLELII
>NC_013037.1|WP_041735735.1|553066_553633_+|DUF4256-domain-containing-protein
MKNDKKELSAEGRDELLATLKARFEKNKARHEGIRWANVEARLEARSEKLWTLDQMELTGGEPDVIGFDKQSGEYIFCDCSPESPKGRRSLCYDRDAWNFRKENKPENTALDVAAEIGIEILDEETYRHLQTLGKFDLKTSSWIKTPANIRKLGGAVFCDRRYDTVFYYHNGAESYYAARAFRGTLRV
>NC_013037.1|WP_012780120.1|567308_567677_+|glyoxalase/bleomycin-resistance/dioxygenase-family-protein
MDIKFEGGINIAVKIPKSKYEATVAFYRDILKLDVEERPITNPTVSRTHRVSFGGNVMWLDCVDNYTHSETWLELNVENVPAATEYLKSQGISTCDELEELPRDMHWITDPAGSVYIVKNRD
>NC_013037.1|WP_012780121.1|568130_568796_+|DNA-alkylation-repair-protein
MSNLNSKMGQTLKAEGILNQIHPDTKLGDLRKIAKDIGKDHELAMELWSSGNFLPRQLAILIMDSKRVSQSLVDELEKDMQTHPIDERNQLIDWLMANQLMKDKKTIALVESWENAASALQRRVFWYHQGRLRWMGKIPLDNAGELLTKIEAGIVNEKPEVQWAMNFTAGWIGIYEKQHRDRCIALGEKTGLYKGDKVSKGCTPDYLPEFIAIESRKQNMG
>NC_013037.1|WP_012780122.1|569507_570407_-|response-regulator
MNTKDMQLSKTIFLVDDDPDDRLLISEAIHSVIKAVRIVEIQSGIDLLNILSSQPGQFPDLILLDMNMPGINGLETLSQLREKPSQRCFPIIMLSTACNNDLVKQAYMLGVNAFMPKPITSGHYRAVARAVNLCFLNHIDSTPPNLSVSETEKETSLIVIEDNEDHWNLIDMAIRQKKHHLKLIRLRDKSSTLEFLDSCYKRLAPYPKLILLDLYMPTKKDGLSILDSIRYFISVNNLPQVPVFVFTFSDHQQDIDACYAIQANAVITKPTDLTHWPLLFADLLDLWGQTVRLPNNQMA
>NC_013037.1|WP_143828634.1|570443_570953_-|hypothetical-protein
MENISSQISGNHILTTGLGRTMQAEEHFCKVTRQIMKCVSSAEFYRMLGHVLALSEQHQQKLMGSFGVVAATSSETAADEFEQHIDAVACGKQTAAANDLTYTWLITKIIQRKIDCYEQVLSIIDSQQLHHHKRILGAALSDETATELFMQELAERLFLRQFPEHASLA
>NC_013037.1|WP_012780124.1|571010_571238_-|hypothetical-protein
MKAKPIIASILAALLFSACTKNDNVKEASDTGTPIDTAVVGKDTSPVSTRKDIENSDEQKLTLPGRDTTNTDERQ
>NC_013037.1|WP_143828873.1|571234_572260_-|SDR-family-NAD(P)-dependent-oxidoreductase
MFAISALTSLLLTGCATKQLSKSDRRKVQGKTFVVTGASSGFGRGVALRLGEYHANVVLAARRGEVLESVAADVRKAGGQAIVVLTDVGRQQDVERLADTTVKVFGKADVWINNAGVGAIGGFEDIPLDEYSKLIDVNLKGVVYGSQAALKLFKKQGYGKLINTGSVESAVPLAYHATYGSTKAAVRALGNVLHQELRLSGHLKKIKVVTIMPWAVDTPFWRHAANYSGGTPRMAAMDGPEKVVNAIIFSSLHRRRELPVGWKARASYISHRLMPHLTERISANIAYRYQIKTAPPAPPTKGSVMLPMPEGQGIDDGVRQRMKAEKKEQKGRKDSNKRIEQ
>NC_013037.1|WP_012780126.1|572329_572848_-|DUF4142-domain-containing-protein
MKKLLLPLGIVSLFFVASSCTDHDSDGMLNQTDRDFMMKAADANLFEIKAGELASGKAAADSVRHYGHHMVTDHSMATVELKSLAEKKMVTLPENVSAAKQMKLDSLAMLTGMRFDSVYMAMMVISHVETIDQFNLETTLGHDPEVKSFAAGKLPVLHHHLEEAIRLKEWLW
>NC_013037.1|WP_187293420.1|572941_573454_+|hypothetical-protein
MRYIKSVPARYAPLALDNRVFAVRPVCDHIAYGIIFNSGPRFDDYPYKLSKEMKMKKLVMAAVAFAITVSATFAQSTTNSTNPNIQPEDTVKQNPASDRSTGGPRNTSDGARHTRQGKPDRASPAGRATNAGRRTNANNESKVSKGGKVNQAAKSNNATGKPGQAAKKDD
>NC_013037.1|WP_012780128.1|573580_574312_-|FRG-domain-containing-protein
MKSIRIHTVDQYIRQILALSKEASDFCIFRGQRVKAPLTPSIARYDLTDSIPQVEKRMLADLKRMGKMLIGSPVTDDWELLILAQHYGLKTRLLDWSSNPLVAMFFAIRDIDDSQNPSYVYAFTGDEGQVFDKDNAMAGQKGGSPFEITELKVLRPSLNNERIIAQSGWFTVHPYDQVQNKFVPMDQDQEVSESVTEFVIDADIKAKLIDDLNMLGFNAQTMFPELAGLCHYLNWQYLRAPSL
>NC_013037.1|WP_012780129.1|574308_575184_-|cyanophycinase
MSRTDIKSPHGKLIAIGGKEARSSEEGMLAGSTREPAHDSGSILTHVLAEIKGPASRIEILTTASEQRSEMADMYTEAFRKLGCEQVGILDLDGRNVDSKETLQRLAAADGLFMTGGDQTRLIEKIGGSEFLKNLKRRYQQDDFTIIGTSAGAMAMSEVMINEGDSTESLLKGIVSLSRGFNFLPKTVIDTHFMSRGRFSRLAEALLMHKGMTALGICEDTALVVGDGGIARAIGSGIVMVLEAEKVRSTNFKEAKKGEAIYVEGMQIHILASGAMYSLPEKKFLLSTQPQ

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Crispr_ID: NC_013037_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013037_2

679320-679424

Orphan

Consensus_repeat	Method
GAATTTTGAATGAGTGAATGAGTGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013037_2

>merge|NC_013037|2|679320-679424|CRISPRCasFinder
GAATTTTGAATGAGTGAATGAGTGAATTTTGAATGATTGAATGATTGAATGATTGAATGAGCCGCCGTGGAACGGGGAATGAATTTTGAATGAGTGAATGAGTGA

>NC_013037|2|2|679320-679424|CRISPRCasFinder
GAATTTTGAATGAGTGAATGAGTGA	ATTTTGAATGATTGAATGATTGAATGATTGAATGAGCCGCCGTGGAACGGGGAAT
GAATTTTGAATGAGTGAATGAGTGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_013037.1\|WP_015810115.1\|676651_678184_+\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl\|CDD\|378943
NC_013037.1\|WP_015810125.1\|687233_688223_-\|ketoacyl-ACP-synthase-III	unknown	unknown	gnl\|CDD\|236475
NC_013037.1\|WP_015810116.1\|678193_679315_+\|mannonate-dehydratase	unknown	unknown	gnl\|CDD\|224231
NC_013037.1\|WP_015810123.1\|685311_686382_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|377675
NC_013037.1\|WP_015810106.1\|665150_665918_+\|phytanoyl-CoA-dioxygenase-family-protein	unknown	unknown	unknown
NC_013037.1\|WP_015810121.1\|683441_684239_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_013037.1\|WP_015810126.1\|688355_689102_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NC_013037.1\|WP_015810117.1\|679794_680745_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367064
NC_013037.1\|WP_015810108.1\|667518_668157_-\|lipid-binding-START-domain-containing-protein	unknown	unknown	gnl\|CDD\|176885
NC_013037.1\|WP_015810109.1\|668347_669112_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NC_013037.1\|WP_041734686.1\|686732_687167_+\|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|197918
NC_013037.1\|WP_015810118.1\|680751_681480_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_013037.1\|WP_041734682.1\|670344_671028_+\|PorT-family-protein	unknown	unknown	gnl\|CDD\|372635
NC_013037.1\|WP_015810113.1\|672114_673149_+\|FecR-domain-containing-protein	unknown	unknown	gnl\|CDD\|226235
NC_013037.1\|WP_015810110.1\|669264_670278_+\|TIM-barrel-protein	unknown	unknown	gnl\|CDD\|366542
NC_013037.1\|WP_015810120.1\|682838_683438_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NC_013037.1\|WP_015810114.1\|673224_676632_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NC_013037.1\|WP_015810119.1\|681476_682547_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NC_013037.1\|WP_015810107.1\|666339_667488_-\|galactonate-dehydratase	unknown	unknown	gnl\|CDD\|184455
NC_013037.1\|WP_015810122.1\|684235_685315_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|225814

Protein	Function_ID	Function_description	E-value
NC_013037.1\|WP_015810115.1\|676651_678184_+\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl\|CDD\|378943	pfam12771, SusD-like_2, Starch-binding associating with outer membrane. SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane.	1.12433e-76
NC_013037.1\|WP_015810125.1\|687233_688223_-\|ketoacyl-ACP-synthase-III	gnl\|CDD\|236475	PRK09352, PRK09352, beta-ketoacyl-ACP synthase 3.	9.44001e-177
NC_013037.1\|WP_015810116.1\|678193_679315_+\|mannonate-dehydratase	gnl\|CDD\|224231	COG1312, UxuA, D-mannonate dehydratase [Carbohydrate transport and metabolism].	5.63498e-108
NC_013037.1\|WP_015810122.1\|684235_685315_-\|histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	1.31028e-31
NC_013037.1\|WP_015810121.1\|683441_684239_-\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	1.74513e-31
NC_013037.1\|WP_015810126.1\|688355_689102_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	1.03505e-29
NC_013037.1\|WP_015810117.1\|679794_680745_+\|hypothetical-protein	gnl\|CDD\|367064	pfam02382, RTX, RTX N-terminal domain. The RTX family of bacterial toxins are a group of cytolysins and cytotoxins. This Pfam family represents the N-terminal domain which is found in association with a glycine-rich repeat domain and hemolysinCabind pfam00353.	0.00152171
NC_013037.1\|WP_015810108.1\|667518_668157_-\|lipid-binding-START-domain-containing-protein	gnl\|CDD\|176885	cd08876, START_1, Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family. Functionally uncharacterized subgroup of the START domain family. The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some mammalian members of the START family (STARDs), it is known which lipids bind in this pocket; these include cholesterol (STARD1, -3, -4, and -5), 25-hydroxycholesterol (STARD5), phosphatidylcholine (STARD2, -7, and -10), phosphatidylethanolamine (STARD10) and ceramides (STARD11). Mammalian STARDs participate in the control of various cellular processes, including lipid trafficking between intracellular compartments, lipid metabolism, and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer, genetic disorders, and autoimmune disease.	1.8695e-52
NC_013037.1\|WP_015810109.1\|668347_669112_-\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	1.4115e-11
NC_013037.1\|WP_041734686.1\|686732_687167_+\|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	gnl\|CDD\|197918	smart00850, LytTR, LytTr DNA-binding domain. This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.	4.22118e-16
NC_013037.1\|WP_015810118.1\|680751_681480_-\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	1.24188e-41
NC_013037.1\|WP_041734682.1\|670344_671028_+\|PorT-family-protein	gnl\|CDD\|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	4.11721e-08
NC_013037.1\|WP_015810113.1\|672114_673149_+\|FecR-domain-containing-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	2.9434e-36
NC_013037.1\|WP_015810110.1\|669264_670278_+\|TIM-barrel-protein	gnl\|CDD\|366542	pfam01261, AP_endonuc_2, Xylose isomerase-like TIM barrel. This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.	4.48495e-09
NC_013037.1\|WP_015810120.1\|682838_683438_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	1.23619e-32
NC_013037.1\|WP_015810114.1\|673224_676632_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_013037.1\|WP_015810119.1\|681476_682547_-\|histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	1.08455e-30
NC_013037.1\|WP_015810107.1\|666339_667488_-\|galactonate-dehydratase	gnl\|CDD\|184455	PRK14017, PRK14017, galactonate dehydratase; Provisional.	0
NC_013037.1\|WP_015810123.1\|685311_686382_-\|sensor-histidine-kinase	gnl\|CDD\|377675	pfam06580, His_kinase, Histidine kinase. This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.	6.00964e-24

>NC_013037.1|WP_015810116.1|678193_679315_+|mannonate-dehydratase
MENSRRKFIKNGAAAVTAAAASAGLGAPALALARSHKQAAGYARDGGMQFCLAHFFGIDPTRIALSKQMNVLGAVGGINPQSVGLSNVKNWEYEAVVAVRDFWKQHGITYRVIEGPPSLYEKTKLGLDGKDEEIETFIKFIQNLSKAGIDTVCYNWMPVISWARTKLDKPSRGGALVSSFDHEDVKDKPLTKYGDFTHETMWKNLEYFLKAVVPEAEKVGVKLALHPDDPPVDKIQGIPRIMTSADAFKRLIEIVPSESNGITLCQGTFATMGEDIPSVIKYFGSRKKIHFVHFRDVRGDRNNFEETFHDDGKTDMYEAMKTYYEVGFRGPMRPDHVPTMAGDSNKNAGYSNYGALFAIGYMRGLVEAVAKRG
>NC_013037.1|WP_015810115.1|676651_678184_+|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MLKKLTICLALLAGAGACTKDFEEINVNPNAPNTVPVDYLLGQSQLLLTGSASGPASKAWRANFGYAACLIQQMSSIDATFYKGSFYTFLGEINSAFFDNSYTFAVKSMVNLIDVAQKDPKNVNVLSMARIIKVMEFSRTTDLYGDIPYFEAGKGFIDANFSPKYDAQQTIYMDMLKELEEARNAFDPAQYIPKAADYIYGGDLDKWKRAANSLMLRLAMRMQKADAANAQLWAKKAIDAGLITSNAETIAVKFSNTGAEINSNPNSWILGPSGSNVTNIPNAGVQWAKTLIDMMKTRQDPRLPIISMIKGGDNSVAKQRGLPNATDATGLAQLDEKNLDNYSRPATGVIGIALPWIYMTYAETQLLKAEAIERGWAMGSAKAAFQAGQSAALEQMSWANATIPGADITAYATKNPYPESGTLDAKMNAIHTEVYLIAASTFNHIEGYANWRRTGFPVLTPVNYLGNDTNGQIPRRLRYPLSEEGINPNFKTAIERQGPDVFMTRIWWDK
>NC_013037.1|WP_015810114.1|673224_676632_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MLTASPPLDAQVLALNAHKNRMLPPEQTTHQVKLLDVLLQLKKFYSADILFEESQMSGITVPDFVFDKNLSAEKNMEALLKSTGLVLKKVRKNAYMILPRRIETSAIGSRPSADLQVVAGARAVAAEIKVSGTVTDNNGEGLPGVNVLVKGTINGTNTDVNGKYELDVPSSESVLVFTSIGFQKQEVAVGQRSVVDVKMAVETQTLDEVVVTALGIKKEKKALGYAISEVKGEELTQARSTNIANSLVGKVAGLNISSTATGPSGSSRIVIRGNGSISGNNQPLIIVDGIPINNDNLGSVAIGANREGSWTGSDRGDGISSLNPDEIESISVLKGATAAALYGSRASNGAILVTTKGGKADKGIGVEVNSNFLAEDLLFKSYKDYQYEYGLGSNGVKPTTVAETATRNSWGGRLDGSNSINYDGVERPYVAAKDNLRKFYNVGTTFTNSIALTGATEKVTYRLSMSDLNNKGVLPNNTLRRNNFALNTNGNLGKRISFVANAKYIIEKNHNRPRVNDSPGNANFAMYVLPTSLDVDVLKNAQFDANGNEKVWSDNQYTQNPYFATEQFQQDDNKKRVIASFEPKYTITDWLYLKGRIGFDNFNYRYKSIEPYGTGYVLRGSYTSSLREFTETNKELLVGINRKMGEKFAFSGLFGGNMMKQVTNLNEVSANNSFNIPFFYDISNIDPAARTVTEAYIEKRINSVYGSAEFSYNNYLFVTATARNDWFSTLAKGKNSIFYPSFGVSFVASEALKMPAVINYLKFRGSWAQAGGDTDPYNLSLYYSLSGAHLGSALAQINGTRVPNSGLQPLTSTVSELGLEAKLFNNLLNVDFAVYDRKTTDDIVSATISQTSGYTSALFNVGAIRNRGIELLLGATIVNSKKFTWDASFNMGYNDSEVLSLYGDLQTLRVDQSRPGSAFIHQDVGKPYSQIKGYDFKRDASGNIVYNSQGLAMAGDIKTFGSGVSPYTLGLNNTFNYKGISLSVLVDGKFGGYIYSGTNALAYRFGLHEATLVGREGGVTGEGVTESGEPNTAKAPAQAYYSNWYSAIATPFVHKSDFIKLRQIIFQYSIPSRFLGKMPFKGASVSIVGRNLAVLMKKVPVIDPEATYNNGNAQGVEFAGTPPTRSYGVNLNLKF
>NC_013037.1|WP_015810113.1|672114_673149_+|FecR-domain-containing-protein
MNTLSVNKALLFLYFAGHANPVQKRLIAEWLAQAENQELYFEWLAEWQSQSPQFLPDGQERYEAYVRFMRENRHIGPSNAASPSENDGQHSGTAAKSTRIGRRPWLMAAASVLMMGMTAWFGRERILYKTYATGFGETRSVQLSDGTGVILNANTSLRVPRFGFGEATREVRLNGEAFFNVTHTIDNKRFMVKTEENFEVMVLGTEFSVYTRQKGGKVLLKKGKVHVLFSEGREKKQLVMKPGDLMMMEKAAAKPVVKPNADTQKLTAWTGNRFIFDKTPLSEVATQLQEHYGIRVEIKDNRFANRTVSGTFQPESGEELLTLLSELFNFRLAREGEAYLILQK
>NC_013037.1|WP_041734682.1|670344_671028_+|PorT-family-protein
MKRCCAILVLTALTQAFVFGQSETEARRWHFGAFAGPQLAFSLPKQSGSKPSRGMIAGVDVGYRFQNGARGWSAHVQPNFSLLRNSTTSGDETTVQFTTLESEASSVHLPFFVRYTFMDGKIRPFAEAGGNWAMRTNVSYQTTGRFCPDGAACTPIESDDKIKNAEVNRIGALISAGVQIDAGKAVIPITLRVIQDVIRREIDLEPIGGTYRNPRGRLIQLTAGITF
>NC_013037.1|WP_015810110.1|669264_670278_+|TIM-barrel-protein
MNTTRRQFLGQLGLATAGLGFAPLAARPAAKFSFDISLAEFSFASELFSGKMTNMDFPARAKNDYNITILEYVSGFFNNKHKDQVYLKELKQRCDDLGMKNHLIMVDGENLTALDDAARTKAVEAHYPWVDAAKFLGCSAIRVNLGDAMAMLSGKKEEGTPAQLATAAVDGYGRLLEFAGKAGINVIVENHFGVSTDPDWLVGVMKQLKAPNKGLLPDFGNFCAERSKPETLDIKGFMATKCVKEHDKYEGVRKMMPYAKGISAKTHQFDANGNDPETDFIKIFKIIKDSGWNNGIVGIEYEGGLMREMGGDTSKPTNDEGIRKTKALLEKVLKELG
>NC_013037.1|WP_015810109.1|668347_669112_-|NUDIX-hydrolase
MEHKLREFFDNALKEVSLDCTVFGFHEGELKVLLLRWKGTEEWSLPGGHILLDESADDAAGRILSQRTGLSDVFLQQFYTFGNVNRYVYHPEKELLEKLEATFGKGFFDGIIFRRTVSIGYFALVEFAQVQPTPDWFTDECRWWSLAEVPRLLFDHNEMIERALKALRQRIRNQPVGYNLLPEKFTMPELQRLYETILDRPFDRRNFQKLLMSYDILERLEEKRVGAANKSPYLYRFVKEKYDRAGLEGISFSM
>NC_013037.1|WP_015810108.1|667518_668157_-|lipid-binding-START-domain-containing-protein
MPKFTLLFIFALITAPVIAQHKWKLIADEEQIRIYSSAVPDSKIKAIKVDCVVDASLAQMAALVMDVEAGTQWVYKTKSCTLVKKLSPNDLYYHSEISLPWPLDNRDFVAHLVAKQNPLTGVVTIDGPVVAGIVPVKKNVVRVKDSKGRWVLTPVQGKVRIEYTLHTDPGGYVPAWAVNAFAAEGPMETFKSMKQQLKLPKYTNASLTFIAN
>NC_013037.1|WP_015810107.1|666339_667488_-|galactonate-dehydratase
MKIRSYELFQVPPRWLFLKIETDEGIVGWGEPVIEGKAATVAAAVHELMEALIGKDPLDIEGHWNTMYRGGFYRGGPILMSAIAGIDQALWDIKGKFFNAPVYQLLGGKCRDKIKVYSWIGGDRPDEVAGAATECFDRGFKAIKMNATNEMQYIDSFEKIDLAIKRVASIREALGYKIEIGVDFHGRLHKPMAKVLAKELEPFRPMFIEEPVLAENNEALREIAAHTSIPIATGERMFSRWDFKNLLMDGYVDIIQPDLSHAGGITECKKILSMAEAFDVAAAPHCPLGPIALAACLQVDATSHNAFIQEQSLGIHYNQGSDLMDYLTDRTVFDYHDGFVNIPSGPGLGIEVDEEQVRKMAAIGHNWKNPLWSHDDGSAAEW
>NC_013037.1|WP_015810106.1|665150_665918_+|phytanoyl-CoA-dioxygenase-family-protein
MEGILNAQQTDQFIEHGFVRIDQAFTAETAAQARHILWNDLGLSPNDPATWTKPVVRLGMYAQEPFVASANTPILHAAFDQLVGAGKWLPCRSMGTFPVRFPSDEDPGDTGWHVDASFPGDDPSNYWEYRVNVHSKGRGLLMLFLYSDVGEHDAPTRIRIGSHKDVARVLAPEGDRGLAFMELAEKLAGMPEREVALATGKAGTVYLCHPFLAHAAQPHHGTEPKFMAQPPLLLRGDLSVNGPSCVERAIRLALA
>NC_013037.1|WP_015810117.1|679794_680745_+|hypothetical-protein
MKTFATTAFAVILFLCVWTERRGKEGTINPIIGDISFEKKYGTMPDADTDDNLRIAAHLEYAEALLRKRDVSRLSPAMRTKRALMLDHLRDYRLAGSFPKNYDREERKPCFIDRNGTICAVGYLVEQTAGRAAAEDISRRHQYATILEMNDRKVDEWIAQSGLSKEECAIIQPQYGASGAQNVNDVKPAYGIASALLMGTNTALSTVNAVQGAKRSASGGAPVMGIVGGTGQIVLGIVGFHKKAELTGLMRQDYHTNMQRGISMVNMGLGSLTLGLSIWNLAAKKQPVEKRSAWDMRSFPDANGKSGVALSFTHKF
>NC_013037.1|WP_015810118.1|680751_681480_-|response-regulator-transcription-factor
MTLNCITVDDEPLALGLVSSFVEQTPFLHLHGRYINALDALEVITKENIHLVYLDIQMPELTGMELAKVLSQNPDTRTRIVFTTAYNQFAVQGYEVDALGYLLKPFGYNQFLATAMKAKKYFENLREASNDPELDSSENYLFVKSDYKLVRIDFDAILFIESFKDYVRIHQANGSPVVSHSSLKAIEEKLPAGKFIRIHRSFIVSVGKVDSISKSAVHIGSVDIPVGDLYKDAFKELLAKWH
>NC_013037.1|WP_015810119.1|681476_682547_-|histidine-kinase
MTFENTKGGVVAAMHLLAWALLGFVLVFYQPLSWGVSLPAVFWVKQILNFALLVALFYFNARYLVPRYLLKNRILVFILWVIALAALMLIVSKLADQQLEVRRHMERIMPRPRHHGGPKPRHMIDGILLMTTLLVIGVSTSMAVIQRWQADARLRDSVEKQNITSELALLKAQINPHFFFNTLNNIYALSYTNVEESREATLTLSRMMRYLLYETQHDHGPLSREFEFIDDYIELMKLRVQSSSNVHYTRDEAIPDYPIAPMLLLPFIENAFKHGMNAAQESEIRIHAGLSNGALNLHVKNHIFPVQNVAGAESGGIGLSNTRRRLDLLYPEKHRLEIHTDESANTYTVDLTINLI
>NC_013037.1|WP_015810120.1|682838_683438_+|RNA-polymerase-sigma-factor
MLKFLNKIIFDPNDFRSVIAACIAGNSQAQHILFKKYFGYAKSICLRYTYSPEEAEEVLNEGFFKVFNNLERYDPAQPFKAWLRTVMVNNAISYFRRNKKHYTARTAFDEIPEPGVADDVVSDMTAGEIMQLIHELKPIYKTVFLLYAVDGYCHKEIAAMLEINEATVRSQYARARAQLQETIAARYPDLAGQYAMLSL
>NC_013037.1|WP_015810121.1|683441_684239_-|response-regulator-transcription-factor
MNVLIVEDEKLAVRKLTKLLEETAPEFEIRGITPSIAATVDWITENRQNGKPEPDIIFLDIELADGQSFEIFNRVEVRSTVIFTTSYDEYALQAFKVNSIDYLLKPVQQDDLQRAIRKYYDLTAPGKVGTAPSAQLHLETILKSLHLHTPAPEYRKRFLVKQGARLLSVETSEIAYFFVDGGLTFFKNHQGQKFVVDYKMDELDEFLDPARFFRVNRGLMVTHQAVAQMQPYYNHRIALTLHPSLDKETIVSRERANDFKVWMGK
>NC_013037.1|WP_015810122.1|684235_685315_-|histidine-kinase
MNPTLSYNQIGREIWLSLFGRWIFALLVPWFVPTISYLLIGQPYLESLYNFIGGTLMIFLMTIVAFVPHDWAARYIARRYPSLDSTFRRSALTAAAFWILTFVFVTAYMLFIIRFRPFEAELDGRMIINVYLFEFVAVLLLTVLYEINYSLNEWKTLKINKELLKRAGMQGQLQSLKSQVNPHFLFNSLNTLSALIADEPKRAEQFVDEMAKVYRYLLQTNQNELTPLSAELRFIRSYYHLLRTRYDTGFELMIDVSEADLEKNIPPLTLQLLLENAVKHNSILESNPLKVSIRSMGDDLLEISNNRLIKSTPVKSTRLGLANITAKYELLSDRMPAIEDGEGIFKVTLPLIPLKTANA
>NC_013037.1|WP_015810123.1|685311_686382_-|sensor-histidine-kinase
MIIEHYLAKFGRKQLSATASVLLLGGTALLAGFGLWQERYFSDSRHFLIGSCINLAAIWAAYRIDTLLSVRVTRFFPETEQSISRVASWFGAYAAVNVALFWAALPVYRLAGLGGQGADLQWAMRVSFFILSASLIGAGLTELTYAFRQWRSNQDELEVMQEKQLQTELDAVKQQVNPHFLFNCLNSLSVLIADAPATAEKFVDEMSKVYRYQLSVNGPDKEDMLVSLDSELRFIRSYIYLLETRFEAGISVDLDVREVFLCGQMVPLTFQILIDHAIHYNVVSAARPLHIRISTTETGQLEFAHNRQPKMLSMPLETPGISVLTSRYKLLFNRAGAVQYKEDDQQFAIIVPLIFT
>NC_013037.1|WP_041734686.1|686732_687167_+|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein
MKVTNAMPDQSMKNQSALSPMKNLSIITTGAAGEVMSVPAITVYKFGKAITVKSSDITCLEGVGNYTFVYTRHEKHLVSKCLKEVQDELSSDFLRIHKSYSINARHIKSRWPDYIHLSCGKVIPIARRRIRETHEILGRMALSA
>NC_013037.1|WP_015810125.1|687233_688223_-|ketoacyl-ACP-synthase-III
MRQVTASISGIEGYVPDYILTNAELETLVDTNDEWIVSRTGIRERRILKDPGLGSSHMGARAVQGLLEKTNTDPAEIDLLICATITPDFVFPSTANLICDQLGIRNIGSFDVNAACSGFVYGLELGAQFIETGKYKKVVVVGTDKMSAVMDYTDRRTCILFGDGAGAVLLEPNYEGYGVIDTLIRADGAGYNNLLQRGGGSRYPATHETVDARMHYLYQDGQQVFKSAVRNMADVSAEMMERNRLSHDDVAWLVPHQANRRIIEATASRMGVGMDKVMMNIERYGNTTAATIPLCLWDYEKQLKKGDNLIFSAFGAGFTWGSAYIKWAY
>NC_013037.1|WP_015810126.1|688355_689102_-|OmpA-family-protein
MKTFTAIVVLCLLGSPAFSQPVQANSKAAGSLRQRSRVSIRVLDKFSLRPVRATIMLVGNHPGRQVAPRFENGIYQFRMSAGDTSVISIHASGYEMLSEAVAGRDLHATKIFYLTPIENSTERAREPVIEQNIPVLEDDIRATLHFPQSESDILPESGYELEILAGYLVRNAGSRIELMGHTDDVGDPFKNLLLSFDRVDEVRKYLVSKHIETTRIRGKGFGSDLPVAPNDCEANRRLNRRVEIRIVP

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Crispr_ID: NC_013037_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013037_3

1176018-1176092

Orphan

Consensus_repeat	Method
GCCCCGTAGGGGCATCCTGTTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013037_3

>merge|NC_013037|3|1176018-1176092|CRISPRCasFinder
GCCCCGTAGGGGCATCCTGTTTCTAGCACAAATGTCGAATCGCACCGTTTGTGCCCCGTAGGGGCATCCTGTTTC

>NC_013037|3|3|1176018-1176092|CRISPRCasFinder
GCCCCGTAGGGGCATCCTGTTTC	TAGCACAAATGTCGAATCGCACCGTTTGT
GCCCCGTAGGGGCATCCTGTTTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013037.1\|WP_015810517.1\|1192438_1194637_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|199838
NC_013037.1\|WP_015810507.1\|1175214_1175988_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_013037.1\|WP_015810498.1\|1160400_1164765_+\|CusA/CzcA-family-heavy-metal-efflux-RND-transporter	unknown	unknown	gnl\|CDD\|226220
NC_013037.1\|WP_143828892.1\|1169215_1170505_+\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NC_013037.1\|WP_015810515.1\|1187722_1190707_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|274948
NC_013037.1\|WP_041734753.1\|1178037_1181172_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NC_013037.1\|WP_015810512.1\|1184108_1185146_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_013037.1\|WP_015810504.1\|1170512_1171556_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NC_013037.1\|WP_015810499.1\|1164773_1165919_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NC_013037.1\|WP_015810514.1\|1186437_1187685_+\|galactonate-dehydratase	unknown	unknown	gnl\|CDD\|184455
NC_013037.1\|WP_015810502.1\|1168472_1169087_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013037.1\|WP_015810516.1\|1190902_1192387_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|185760
NC_013037.1\|WP_015810513.1\|1185191_1186433_+\|mandelate-racemase/muconate-lactonizing-enzyme-family-protein	unknown	unknown	gnl\|CDD\|239432
NC_013037.1\|WP_015810510.1\|1181183_1182725_+\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl\|CDD\|378943
NC_013037.1\|WP_015810500.1\|1166054_1167608_-\|sulfatase	unknown	unknown	gnl\|CDD\|293763
NC_013037.1\|WP_015810505.1\|1171577_1174664_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NC_013037.1\|WP_143828891.1\|1167853_1168219_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_143828671.1\|1174678_1175041_-\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015810511.1\|1182759_1184112_+\|2-dehydro-3-deoxy-6-phosphogalactonate-aldolase	unknown	unknown	gnl\|CDD\|239438
NC_013037.1\|WP_015810508.1\|1176193_1177366_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|225814

Protein	Function_ID	Function_description	E-value
NC_013037.1\|WP_015810517.1\|1192438_1194637_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|199838	cd10280, PQQ_mGDH, Membrane-bound PQQ-dependent glucose dehydrogenase. This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.	0
NC_013037.1\|WP_015810498.1\|1160400_1164765_+\|CusA/CzcA-family-heavy-metal-efflux-RND-transporter	gnl\|CDD\|226220	COG3696, COG3696, Putative silver efflux pump [Inorganic ion transport and metabolism].	0
NC_013037.1\|WP_015810507.1\|1175214_1175988_-\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	1.88319e-52
NC_013037.1\|WP_143828892.1\|1169215_1170505_+\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	7.00644e-24
NC_013037.1\|WP_015810515.1\|1187722_1190707_+\|TonB-dependent-receptor	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_013037.1\|WP_041734753.1\|1178037_1181172_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_013037.1\|WP_015810512.1\|1184108_1185146_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.98482e-102
NC_013037.1\|WP_015810504.1\|1170512_1171556_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	3.94143e-49
NC_013037.1\|WP_015810499.1\|1164773_1165919_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	8.24808e-31
NC_013037.1\|WP_015810514.1\|1186437_1187685_+\|galactonate-dehydratase	gnl\|CDD\|184455	PRK14017, PRK14017, galactonate dehydratase; Provisional.	0
NC_013037.1\|WP_015810502.1\|1168472_1169087_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.14391e-14
NC_013037.1\|WP_015810516.1\|1190902_1192387_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|185760	cd08977, SusD, starch binding outer membrane protein SusD. SusD-like proteins from Bacteroidetes, members of the human distal gut microbiota, are part of the starch utilization system (Sus). Sus is one of the large clusters of glycosyl hydrolases, called polysaccharide utilization loci (PULs), which play an important role in polysaccharide recognition and uptake, and it is needed for growth on amylose, amylopectin, pullulan, and maltooligosaccharides. SusD, together with SusC, a predicted beta-barrel porin, forms the minimum outer-membrane starch-binding complex. The adult human distal gut microbiota is essential for digestion of a large variety of dietary polysaccharides, for which humans lack the necessary glycosyl hydrolases.	8.76586e-39
NC_013037.1\|WP_015810513.1\|1185191_1186433_+\|mandelate-racemase/muconate-lactonizing-enzyme-family-protein	gnl\|CDD\|239432	cd03316, MR_like, Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. Members of the MR subgroup are mandelate racemase, D-glucarate/L-idarate dehydratase (GlucD), D-altronate/D-mannonate dehydratase , D-galactonate dehydratase (GalD) , D-gluconate dehydratase (GlcD), and L-rhamnonate dehydratase (RhamD).	3.58475e-92
NC_013037.1\|WP_015810510.1\|1181183_1182725_+\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl\|CDD\|378943	pfam12771, SusD-like_2, Starch-binding associating with outer membrane. SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane.	2.32756e-82
NC_013037.1\|WP_015810500.1\|1166054_1167608_-\|sulfatase	gnl\|CDD\|293763	cd16144, ARS_like, uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	9.24012e-180
NC_013037.1\|WP_015810505.1\|1171577_1174664_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NC_013037.1\|WP_015810511.1\|1182759_1184112_+\|2-dehydro-3-deoxy-6-phosphogalactonate-aldolase	gnl\|CDD\|239438	cd03322, RspA, The starvation sensing protein RspA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subfamily share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and catalytic residues, a partially conserved Lys-X-Lys motif and a conserved histidine-aspartate dyad.	8.1891e-160
NC_013037.1\|WP_015810508.1\|1176193_1177366_-\|histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	4.98468e-39

>NC_013037.1|WP_015810507.1|1175214_1175988_-|response-regulator-transcription-factor
MKYRCLIIDDEVLARDVIRTFVQHDHSIEITDEAANGSEAVVKILQHRPDVVFLDIQMPELDGFAVLREVWPHHQPFVVFTTAFDQYALRAFEVNAIDYLLKPFDEIRFHQSLGRLKERLSQKSQPRIEELVNNLLREQKDKEENYLQRLLVKEAGKMYLVKTDDITHFSADGNYISVYTLQKKVYTVYESLGSLESRLDPAVMIRVGRSNIVNMNFISELETYFNGEYIIHLSTGEKVKWTRGYRDNIKAFITKMG
>NC_013037.1|WP_143828671.1|1174678_1175041_-|hypothetical-protein
MLFKTSTTVTSAIDALLRNHKSHRQFLAFSAILAMVILWKIIAGTNAASPGETVHSTETASTDQKMAGMKWSYDELAHKLIIENTDLAYVEIGAGFSKGIGRAFSKVARQNSGKRVLVNL
>NC_013037.1|WP_015810505.1|1171577_1174664_+|efflux-RND-transporter-permease-subunit
MKLPEFAVKNYQFTLVVFLGVLALGLYSLFTMPRSEDPDIHPPQFTVVVVYPGANPKDMEQLVVDPMEKKLNELDDMKHIITDIRDGLAVMQIMYKYSSDPDDKYQEVVREINALRSQLPADIADIRINKQIPSDVSIYQYALISENATYAQMKKYSKDFKERLEKIKTLKKVDYSGIPEPQVKVNLNLQKIAQQKLTQDQIVGALQSEGVNIPGGSISMATKKLNIKTSGSYRTLDEVANTVVSRSNGKIVYLKDVADVKMGYEDETHITRLNGFRCSFVNVSQKEGENIIAVRDQVEPVAAAFEKDLPANIELVKVFDQAGSVDTRLSHFARDFAIAILLVLLTLLPLGTRASLVVMISIPLSLAIGLTMMNLLGFNINQLSIVGMIVALGILVDDSIVVVENIERYLRMGYGKVQAAIQASSQIGLAVVGCTILLIFAFLPLVFLPEGAGDFIRSLPMSVITTVFASMLVSLTVVPFLSSVILKPHASEDGNWLLRGMKKGIHKTYGSVLDRALHWPKTTLAIAGLIFAGSLALVPLIGNSLFPKSEKPMFLIDIETPQGTNLKKTNEIARYVEGVLKQEPLISSFATNVGKGNPRVYYNVVQRNESENFAEIFVQVAGLETEEKVAVIEKLRKKLEGYPGAEIKVKDFEQGPLIEAPLAYRIYGEDLDDLRKTAFRVADLLAKTEGTIYVNNPLLVQPTDLRININKQKAGTLGISSADIDRTVRLGAAGLNVATFREDVGKADSYNINVSVPRNAATQDYSVFDKLYVTSASGASIPLKSIATIEMESSPNQIRHYDKDRYVTVSAFAKPGYNVQKMNEGITAKLNQFKFEEGQHFKVAGEKESQEESFGGLGLIILITVFGFLGVLILEFKTFKSILIVLSVIPLGIVGGLAMLFLTGETLSFTATIGFIALVGIEVKNSLLVVDFTNQLREQGKSIEEAIIEAGEIRFVPILLTSMTAIGGLLPLVIEYSALYSPLALVLIGGLISSTLLSRLVTPVMYKLLPPKVEPQQVTQEAELEAAY
>NC_013037.1|WP_015810504.1|1170512_1171556_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MKATTHPIIYAYVLAAALFTSACKEEKKPEKTDDTIPVKIISSAALTQAQAVETSGLLGSENEARLSFKIGGIIKDILVKEGDKVRRGQLLASLNTTEIAAQMGQAEENFLKAQRDARRVQNLYRDSVATKEQLENTQSALVLAEKQLDIVKFNLSQTKIFSTADGVVMQKLQNAGEQVQGGTPVLHVSSTSSTDWVVKCGLTDKDWARLKGGEQAEITFDAYPQTFIGRVKTLAQVSDAVSGLYQVEIALNKPAARLASGLFAKVHIYPKEQTSMVSIPVDALIEGENDSAFVFVADGNRAQKKRVKVAFLEGDKAFILAGIGAGARVIREGSAYLAEGSAIRVVQ
>NC_013037.1|WP_143828892.1|1169215_1170505_+|TolC-family-protein
MAQDTRLQGYVDQGLRNNQGLKQQRFILERNLFALKEARTFFYPEVNFSTSYLDSRGGRKISIPIGDLLNPVYSSLNELTNSSAFPKVENVSQTFNPRNYYDARFRTSLPLYNAEINYNTKIRKEQIHLQQAEVDVYRRELVKEIKVAYYACQQADEAIHILENAVTLARENLRFNQALVKNDKAIRTVISRSENELIGLEARLVDARNQSVNARAYFNFLLNSPLENTLEIEQPDESGVLTDTIAAGRREELAKLESLSRLNALSGQLARAGALPKLSTFIDLGSQGDFVSFNRDTRYYLFGVTLDWRVFAHNRTQYKVKQAELEQKATGEQISQVEQQLQLQSKTAANSFQSAVLTYRAAKSQTALSQQYYQDQQKLYREGQLLYIELLDAQNRLIADQLQQSISYLNVQTRAAELERAKASYLFTN
>NC_013037.1|WP_015810502.1|1168472_1169087_+|TetR/AcrR-family-transcriptional-regulator
MAIKERKEREKQEMRNLIIESATRMFLKQGYDKTSIRNIAEDIEYSPATIYLYFKDKDEIFYVIHENAFDILDKHLRQHDVIADPFERLAALGKTYIEFGLSNPDYYDLMFIMRAPMEQIKNEEKWKAGECAFGYLITTLAACLEQGKIRQADLHVTAIQVWSYVHGLVSLYVRERMCILMLPDDATRQMLYHSFDLFLANIKT
>NC_013037.1|WP_143828891.1|1167853_1168219_+|hypothetical-protein
MSVGREAKIVVKGQVARSRSEIVIDYEFLIREKHDIDFREPIGPNHPQYWKLKKSTPERSQLLQLEYSGISRKQLKEVTREFKRLAGAGYTFRYQNEIEERTKYLKGIRVSAMNRRLLSVA
>NC_013037.1|WP_015810500.1|1166054_1167608_-|sulfatase
MMNISIARWLCFAVMLIVSFGTRHALAQSKPNIIVFLVDDMGWQDTSVPFWNKPTDFNRRYRTPNMERLAREGMKFTNAYAMPVCTPTRVSLITGVNAAHHRVTHWTSPDKDKNTDYADKALEAVDWNINGFSPVAGVPHTFHGTALPEVLRQNGYYTVHSGKAHFGSAGTPGSDPVNLGFEINIAGSSIGHPASYSGKANYDSPVNGKPNRNAVPGLEAYHGTDTFLSDAITTEALKAIAKPVAEKKPFFLYLSHYAVHIPLTADPRFLNRYLEAGLDSTEAKYAALVEGMDKSLGDVLRYLDEQKIADNTVVLFMSDNGGLSTSPARGGKAWTHNLPLKAGKGSVYEGGIREPMLVRWPGVTKAGSVTEQYVIIEDFFPTILDIAGVKNARTVQQVDGKSFLPILKNPAFKDERRGLVWHHPNRWIAAEGPNIHYASAFRQGDWKLIYDYRQAKLELYNLRTDIGEEHDVAASNPLKVKELANLLSRQLKTWGAQWPVSKKTGKPVPLPNELPGL
>NC_013037.1|WP_015810499.1|1164773_1165919_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MKPYIVLCAALWTCLSCSTGGQQAPDAEAASTPDSVMRRVSFDPAQIRNVGIEVGTPVLKNIPGVVTLQGKIDVPPQSTISLSFPLGGYLKSTTMLPGMRVRKGQVLAELEDMQFIQLQQDYLTAREKLELAQSEFARQEDLNVGKASSDKVLQQAKAEMETQRILMNALARKLEVIGIAPAKLSADHISKTVPILSPIDGFVSRVNVNVGKYTAPTDMLFELVDPKDIHLALHVFEKDLHTLSVGQRVTAYTNGDPSRKFTAKIILIGKSLTDDRLAEVHCHFDRYSPSLVPGMFMNGEVSVSGSKAMSVPEDAVVRWENKSFVFVERESGEFEMVEIVPGGIMDGFQQISAAGIDAASRVVIRNAYSLLIKAKNAGDEG
>NC_013037.1|WP_015810498.1|1160400_1164765_+|CusA/CzcA-family-heavy-metal-efflux-RND-transporter
MLNRIIRFSVENKLVIGIFMVLWVAFGIYELTRLPIDAVPDITNNQVQIITTAPSLGTEDVERLITFPIEQATANIPGLKESRSMSRFGLSLVSIVFDDDSDIYWARQQVTERLSQVEMPETAGKPELAPVTTGLGEIYQYVVKPKKGFEDKYSLSDLRTTQDWLIRRQLLGTPGVADVSTFGGELKQYEVAVEPSGLKAMGLTITDVLTALSRNNQNTGGAYIEKGPTVLYIRSLGLAGSIDDINHIVVANRGGVPVLVQHVAQVRFAPAIRYGALTMAGYGEVAGGIVMMLKGGNSSDVVGNVKAKIAEISKTLPEGLEIEPFLDRTKMVNNAIGTVERNLLEGAVIVVIVLVLFLGNLRAGLIVASVIPLSMLFAVAMMNLFGVSGNLMSLGALDFGLIVDGAVIIVEAILHHLHAPGGYRGATRLTQQEMDREVSGSASRMMNAAVFGQIIILIVYLPILSLSGIEGKMFKPMAQTVAFAILGAFVLSLTYVPTVSALLISKKISHAPNWSDRLMARIERAYGRALAWTLRFKVALVAGAFALFGVAVLLFSRMGGEFIPQLEEGDFATETRLLVGTNLTTTINAINRISDRLQKDYSEVEKIVSRIGSAEIPTDPMPIEGGDMIIVLKDKSEWTHAKSFPELATKMAATAQEVVPGVTTGFQYPVQMRFNELMTGAKQDVVCKIFGEDLDKLAAYANQLGHIARGVSGTADWYVEELAGMPQIVIDFNRAEIAKYGLNVDDLNKTINAAFAGAAAGQVYEGEKRFDLVVRVGAEGRKRIADVQNLLVSTPGGVQIPLSQVAAVREIEGPNQIQRENTRRRIIVGFNVRGRDVQSIVEELQRKVDAGIKFESGYAITYGGAFENLQQAKARLGIAVPVALLLIFMMLYFTFSSVKDGALIYTAIPLSAIGGVFALALRDMPFSISAGVGFIALFGVAVLNGIVLVSEFNRIRKEGTITDMLQLVMTGTRNRLRPVLMTAAVASLGFLPMAISNGAGAEVQRPLATVVIGGLVTATLLTLFVLPALYLLFNPKNTLHAGPRGATTVIVVLLLVTQAARAQQPRQVTLDEAIQKALAHNRTLQSGRLGEQAADKLRRSAFDIPKTAISADYGNFNSPNNDTRIGISQSIAFPTVYANQRKAREADYLAARAQTRLAEQEVRTGVRRLFFEYAILKEREKLLTHADSIFTGFESKSNLRFERGASNVLEKTAASSQKQQIANQLNLVRHDLDILVERFNFWLQDSLTYVPQRVSSRMPAYALPDTTAVIADLPQIELNSRLTQSAYFRYRTEKGRMLPELSAAYNNQSLRGTQLLDGREINLTGKDRFGYLGLGLNFPLFFKAQTAQIAAARLDWLRARNEAELAEYRLRSDWKTASGEVRKFTENLRYYEQQGLPNAETILAAADRQFAAGEIDYLQWVILARQAIAIKSEYVNALASYNEAVIQLLHLTNH
>NC_013037.1|WP_015810508.1|1176193_1177366_-|histidine-kinase
MLEQSGLPLTVGQFWWYSFCYWGIFAVITFGQLMMLWLLKMGVAMQPHEMFVWLLDGLFWWSTTPLVLYASIRVPVAFKVRDGSSIIKPILFHLCIVTFLNIFINVLHFYITNPLMYRAVGRMVPLENYLFSFFIAYTASFGQYLLLVVGFNKVSYIYRYQQLKQQHFESELHNEQLRGQLANAQLQSLKMQLNPHFLFNTLHSVVSLMVKNDIRKATLMITTLSDLLRAVLVNQSADFIPLQEELKLTRQYLDIQQIRFQDRLKVEYHIDPASELYPVPQLILQPIVENSITHGISDMTTNALISITSHVSAAGMQVTVYDNGLGAASRKTTKGMGLGLQNTLLRLQQAYGTKARLEFQQPVGGGTSVTLHFEGRIEQGDNGGSRSGNI
>NC_013037.1|WP_041734753.1|1178037_1181172_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKKCFTMLVLLLMLGCSAVFAQNSRITGTVTGDSKEVLPGVNVLVSGTSQGTVTDSEGKYALEAPAKASLVFSFIGYTSQTVAVGTRSVIDIQLVQESKSLTEVVVTALGIKREAKTLGYATATVNADQISTNRTPNVVSSLQGKMAGVNISSLSTGPGGTAKIRIRGQSSFNGQNNPLIVVNGVPIDNSNFAGGGDYGQRSANNSDGGDGLSSINPDDIESMTVLKGATAAALYGSRAKDGVVMITTKTRGTGQGIGVDYNLNFTTDTPLDFTDFQYEYGQGEGGKRPTTENPTSGVWSFGEKFQPGMTQVLFDNETWPYEPVRGRVKKFYRTGTNMTNTITVSNNGPNGGFSLSLANTDNRGIVENNKFNRKVVNLGFTQNISKRLTAFGNVNYSKEKNVNPPQIDAQDFATSTVIFTLANSMPFEALKQNQTLPNGDEFVFSRFLVRNNPYYSLSKHFENITRDRLFGNVAVKYQFTDWLYLQLRAAQDFYVRNQDYNIPNGYAPIAKAPVGYVNGSFTQDVRRNTERNLDFILGGNHTFGNLGLDVTLGGNQRYARMDYNSVTVQDFIQPGLYTVMNGRVKNPLYNLSEKKINSLYGAATISWKEFLYLNVTARNDWFSTLAPQNRSILYPSVTGSFIFSQAFPNLPAWITFGKLRAAYAQVGSDNVNPYSNALYYAVDNNSFPNPSGQLVPVGGINASLVPNKDLRPLRIKEAEVGLEMKLFNNLLGFDLTYYHKTTDDQILAAQISDASSYTAQLINVGRSMNQGIELLLTGSPVKTKDFSWDVSFNVSYNNSKVLKLGLAEKDTVITAGGGGGRTLNMVVGKPLGQLYTFTYLRDAQGRQVFDKNSGMPMRNNTLMNVGNALPRYFGGITNTFNYKGITLSALIDFKLGHKMIAGRNINYMRHGLSKRTLPGRAEGFVIGNGVNPDGEVNQTKAAVQPFYESINPLGINEDFVSNAGFWKLRQLTLGYDLGKLLPEKSFVKGLRLSAVANNVLVIKKWTENMDPEEVLNSSDNATGLDFWPGLPPTRSIGFNLNVKF
>NC_013037.1|WP_015810510.1|1181183_1182725_+|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MKATTKYILALLLSLTLVTGCDEGFDEINTNKVDPTSLAPSLMLNKAIIATTYLDGVSTLGMLCYNFGIVQQVITPYGSSLSGGNYNQLNNSNSPLVWVNFYRNVIKQLVAVTEQTKADPMSANIYHAARIWKAYAFMILTDTYGDIPYFDAGKGYISEEIRPKYDPQEAIYRDILKELEEAAGALDTAQPPVTTDILYGGNVARWKKLGYSLMLRAGMRLTKVDSDGAKNYVAKAVAGGVFESNADNSIIRHTAIYNNYIANHLAAREKTNFYLAAPFVNYLKENNDPRLPVFAVRYVGAKGGPEQTAARASSDPKVQIGMPMGYNDVTINSVLAENGVVSLWDFTQINLTTVLKLDAPEFHITYAQVQLLLAEAAVRGWVPGTAADYYAKGIRANLEQMALYDPSAAIKEDAILAYLKAHPLDAAKALEQINTQYWVATFLDGNESWANFRRSGFPALKKNPYPGSEIKEDFIRRMPYPDSEIVVNLQNVNDANARQGPNDLNTRIWWDKK
>NC_013037.1|WP_015810511.1|1182759_1184112_+|2-dehydro-3-deoxy-6-phosphogalactonate-aldolase
MKENGMSRRDTMRALGLSGSAGLLGLFGGIPNALAADRETPQYAKAMKPVTIKSVRAIATAPQGSNLIVVKVETSEPGLYGLGCATFTQRAEVVLVAINTYLNEFCAGKDVDNIEDMWNAAYVSSYWRNGPVLNNALSGLDQALWDIKGKRAGMPLYQLLGGKSRFAVPCYTHANGRTPEEVVESVKKIQEQGYRYIRIQQGGYGAVGSTTKKPDFKEAGFGGPTDNYMDENAYLKAIPILFETVRKQCGDEVELLHDIHERVQPMNAINMIKKLEDYRPFFIEDPFSPENMKWFKLLRQSTTVPLAMGELFNNINEFLEPMVNQWFDYIRIHVSQIGGITPAMKVARLGEWFNVRTAWHGPGDVSPVGHSAHAHIDLTVWNFGIQEAVQFNEKTLEVFSGCPTMKNGYMSVNEVPGIGVDINEKAAAKFPITTKSNWQVRKFDGTLIRP
>NC_013037.1|WP_015810512.1|1184108_1185146_+|LacI-family-DNA-binding-transcriptional-regulator
MKKASLKDIAQQAGVSTALVSYVLNGKEKETRVGEAIAQKIRQIAKELNYQPNHLAKSLRSGKTHTIGLIIADISNPFFANIARVVEDEAKRNGYTVIIGSCDEHAEKSWDLLNVLINRQVDGFIIVSCEGSENQVHYLKERNIPFVLLDRHFPEIQTDFVATNNYKASYDAGVHLIQSGYERIGIMAYKSNMYHMEERVRGYKHALRDNNIEFRDAWLKEVHFETMDSEVRTAIDEVLASDQRVQAMIFATYGLAINALKYINELRLKVPSDLAIVSFGQAEVFDLYYCPITYVRQPLEMLGKTSVEFLLKKLKNPEEGMKQILMEAKLIARESSKAKTGALEG
>NC_013037.1|WP_015810513.1|1185191_1186433_+|mandelate-racemase/muconate-lactonizing-enzyme-family-protein
MQRRNFIKTAFLGTTALATGFPFADSGAASKMKITKIRYYAAPGYNKPLFNQARGIVEIETDGGIIGIGEGGSKDMIEQCAQMMIGEDPFRIEHIWQNVYRGMFYPPGREKLHALGALEMALWDIKGKALNVPVYELLGGATRDYVECYATGFRASKAKTEEERARDCIEAGLRSYRIGPTGGNGDQPFDFYENVKKTIDFCKRIDEAVGGGGKWAIDLHTRFDMTDGLKICNALESLEPYFVEDIIRSENPSVYKTVRAMTKVPIAVGEQFGDRWDSNEFIENRWIDYTRFTLPNTGGISEFKKLASMCETHYVGMIPHFTGPLSTATLVHVLGSSSPARALMELGGGEPERPAYFNEDYINFKNGKLYLNDAPGLGVKFDPKKATFIMEVKEKTKFPHPILKNPDGSIHNW
>NC_013037.1|WP_015810514.1|1186437_1187685_+|galactonate-dehydratase
MKTNPKSTALSRRAAIQSVLGIAATGTMLLPKSSYAAAPTPFQAYGKVKITKLETFLVKPRWIFLKIHTDAGIVGLGEPLLEGRALTIQTAIKEVEPYLVGKDPRAVVHHWQAIYRHAFYRGGPILTSALSGIDQALWDIKGKLLGVPVHELLGGPTRDRVRIYGRASNAEDMKKRKAEGYTIIKTGVAKKNPANIVENPAFIKFASDNFASLREAGGPEMDIAIDFHGAVPQQTSKVLIKELEQYQPFFVEEPCQAQNVDTLVDIARGTHIPIATGERIFTKWGFREILEKGAASIIQPDLCHAGGITEGRIIAGMAEAYYIPIAPHNPMGPISLATGLQLAASVPNFLVQEQVTLGEGYLKEPFKLQKDGTVMVPTKPGLGVELDEDALKDKIGHDWKNPESYNALDGSVVDW
>NC_013037.1|WP_015810515.1|1187722_1190707_+|TonB-dependent-receptor
MRKLFSLCLVFLGLGGSVLAQNARITGKVTDQDNAALPGVSILISGSSQGTVTDGDGNYVINAPGSGTLVFSFIGYESQTVEIGNRSVIDIKLSQGSRSLDELVVVGYGTQRKTDVTGALSVVSTREFSQQPITRLDQVLQGRAAGVQVTQSNGAPGGDSKVRVRGANSVLGNNDPLYVIDGFVGANYNLLNPNDIESLQVLKDAASTSIYGSRGANGVIIITTKKGSKGIKVSYEGQGSVSNVIKRFDILPAGEFAEIVNARALATGSNAPFTQQQVDDFKRNGGTDWQDLVYRKGSGQQHQVTVSGANEKTSFLISGNYVNQKGIVNNSGFKRYILRTNLNTQINKNLSLRLNLSGAKTANHNTDGGGALIEALQWAPTTPAYGADGQPTFNDPTGSVSRSPLDHLYDKSIDTERMNINAIGGLTYQLPIQGLSLDLQYAINYLDAQNKNFNGKRLSNNNPNATRYSSDQVTLQNTNALNYNRTFGNHSITAVAVLETQQFTDKNFTATANGLRFPQLGYDNIGGNSAATVNSAFSKWTLLSLLGRVNYAFKDKYLITAAIRRDGSSKFAKDNRNSVFPSVAVGWRLSEEEFIKNLNVFSNLKLRGSWGKTGSQAISPYATLSPYNSTQVGFNNTAVTAGVIQGNQGNRNLKWETTTQTDVGIEMEFLNGRLHVEADYFNKRTTDLLLNVQLPNYAGGGTQTRNVGEIKNTGFEFAIGGTPIEKGKFSWETNLNISTLKNEVVSLGGLPRLGTGTGAGGGMSITNEFMLMPGQSLGSYWGLKYLGTFKPDEADIAAKQGRVPGDPHYEDVNGDNAITTDDFQIVGRAFPRMTGGWNNTFTYGGLTLNVFFQGAFGVDKLNYTRAGAMSGSGEARQFLLTEIRDYYRPGNEDSDIPAFTKTYQPFTQSSRFVENGSFVRLKNVSLAYTVPSVFKDKANIRIFASATNLLTITKYTGPDPETSNVGSSTDTAIGIDRGSYPNAKVYTLGLTLGF
>NC_013037.1|WP_015810516.1|1190902_1192387_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKKTTILLLTSLLFTGAGCSDYLDEDTRGLLYGPNVLSTQDGLESALTGAYKGLGNQWSYGFLHPSANAAVLGADDVTTHPASNKADWREFDQFNVSTTNQRSNAVYNGCYKAIQGANNVINNWEKTQGTKATIDIIMGEAHFIRAFSYYWLTRFWGNIPLVLAGEYSDELLTVKKSTPQEVYDLIVADLKIAETNLPNAKRDPGRPNKGAAKAFLADVYLTMAGWPLKQTDKYDLAAAKAKEVIDNASAYGFELLPTFAAVFDNDPASPGTREAVFQISGYLGGSGTANATYGNTTMPGEEGGWDDMFAELNFFRDFPAGPRKDATFRTEFGLGATKIPWQNSLTKHPYYQKWYIKGNIVTSSISLPSVMMRYPHVLTIYAEAKARGTGGPDQAAYDALNKVRLRGWAAGTKALAPADGLTAAQFADEVVQERAWEFACERTRWFDLVRLERVEEANAKKSADDLQPIKPIVKANYWFPLPYTDTSINPNLNQ
>NC_013037.1|WP_015810517.1|1192438_1194637_+|PQQ-binding-like-beta-propeller-repeat-protein
MTTRFSFAVSLLLSAALSTPVCAFQEGLRDADWPVYGGNNAGNRYSSLTQVNKENVKKLQPAWTYDTGENNKPGERGMDIQCQPIVIDGIMYGTTPRLKVFAIEAATGRELWKFDPFEGKRPRFHPMRGVVYWAEGKDKRILFTAGPSLFALNAETGKLVETFGKNGEVDFHDGLGDKETYGYDPYQFNIRNTTPGVIYKNLLITGSSVSEGGDALPGHIRAFDVRTGKVAWVFRTIPLPGEYGYDTWSKDSYKKLGGANCWAGMVIDEKRGMVFLGTGSPSVDFYGGPRKGINLFANCVIALDARSGRRVWHYQTVHHDLWDRDIPCPPNLIRVRRNGRMVDAVAQATKDGYIFIFDRDTGKPLFPVKEVPVPNAKALPGDQPWPTQPVPVKPAPFANQTLTEADITTRTPEAHAYVLDRFRNSNKGPKNQPPDTLGGLLYGIGGGAEWGGTAADPQGVVYVNGNNMLWWLKMRDSRKSDGKQGQALSRGQVLFNTNCAACHATEAGTASAATQAYPVLKDIGQRMNREQIAALLETGRGRMPSFQHISKEDRAAIVDFLLKVENKPAANDIHAQTQTGMAKTNAVFPHQPPYINNGNVQFRDQDNYPAIKPPWGTLNAIDMNTGEYRWKVTLGEYPELTRQGVPPTGTENHGGPLVTAGGLLFIAATYDEKLRAFDTETGKVVWEYKLPAGGFATPVTYMVNGKQYIAIAAGGTRYGLKPGGSYIAFALP

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Crispr_ID: NC_013037_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013037_4

1446747-1446824

Orphan

Consensus_repeat	Method
CGGAGCCAAAAAATTACGCCGAGATA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013037_4

>merge|NC_013037|4|1446747-1446824|CRISPRCasFinder
CGGAGCCAAAAAATTACGCCGAGATAACTTTGCTATAAACAGGAGGCTCCTAGCGGAGCCAAAAATTACGCCGAGATA

>NC_013037|4|4|1446747-1446824|CRISPRCasFinder
CGGAGCCAAAAAATTACGCCGAGATA	ACTTTGCTATAAACAGGAGGCTCCTA
GCGGAGCCAAAAATTACGCCGAGATA

Protein	Signature genes	Signature genes Name	Protein_function
NC_013037.1\|WP_015810720.1\|1444625_1445039_+\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NC_013037.1\|WP_015810713.1\|1436303_1438682_+\|type-I-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|236048
NC_013037.1\|WP_015810729.1\|1455386_1457306_+\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NC_013037.1\|WP_015810712.1\|1433203_1435975_-\|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase	unknown	unknown	gnl\|CDD\|236424
NC_013037.1\|WP_015810718.1\|1442483_1443551_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341285
NC_013037.1\|WP_015810717.1\|1441717_1442491_-\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015810723.1\|1447866_1449066_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_013037.1\|WP_015810715.1\|1439429_1440311_+\|bifunctional-5,10-methylene-tetrahydrofolate-dehydrogenase/5,10-methylene-tetrahydrofolate-cyclohydrolase	unknown	unknown	gnl\|CDD\|184556
NC_013037.1\|WP_015810721.1\|1445025_1446606_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_143828895.1\|1457525_1457711_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015810722.1\|1446972_1447860_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|224017
NC_013037.1\|WP_015810726.1\|1451874_1452069_+\|50S-ribosomal-protein-L35	unknown	unknown	gnl\|CDD\|234676
NC_013037.1\|WP_015810731.1\|1457707_1458526_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187616
NC_013037.1\|WP_015810719.1\|1443748_1444573_+\|1,4-dihydroxy-2-naphthoyl-CoA-synthase	unknown	unknown	gnl\|CDD\|180958
NC_013037.1\|WP_015810728.1\|1452662_1455209_+\|phospholipase-C,-phosphocholine-specific	unknown	unknown	gnl\|CDD\|274561
NC_013037.1\|WP_083769047.1\|1451181_1451739_+\|translation-initiation-factor-IF-3	unknown	unknown	gnl\|CDD\|234582
NC_013037.1\|WP_015810716.1\|1440530_1441715_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NC_013037.1\|WP_015810727.1\|1452173_1452518_+\|50S-ribosomal-protein-L20	unknown	unknown	gnl\|CDD\|179959
NC_013037.1\|WP_015810724.1\|1449127_1451071_+\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234752
NC_013037.1\|WP_015810714.1\|1438736_1439429_+\|NAD-dependent-deacylase	unknown	unknown	gnl\|CDD\|238703

Protein	Function_ID	Function_description	E-value
NC_013037.1\|WP_015810723.1\|1447866_1449066_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	3.12682e-18
NC_013037.1\|WP_015810713.1\|1436303_1438682_+\|type-I-DNA-topoisomerase	gnl\|CDD\|236048	PRK07561, PRK07561, DNA topoisomerase I subunit omega; Validated.	0
NC_013037.1\|WP_015810729.1\|1455386_1457306_+\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NC_013037.1\|WP_015810712.1\|1433203_1435975_-\|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase	gnl\|CDD\|236424	PRK09238, PRK09238, bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated.	0
NC_013037.1\|WP_015810718.1\|1442483_1443551_-\|AMP-binding-protein	gnl\|CDD\|341285	cd17630, OSB_MenE-like, O-succinylbenzoic acid-CoA ligase. This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.	7.12361e-110
NC_013037.1\|WP_015810720.1\|1444625_1445039_+\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	5.88136e-55
NC_013037.1\|WP_015810715.1\|1439429_1440311_+\|bifunctional-5,10-methylene-tetrahydrofolate-dehydrogenase/5,10-methylene-tetrahydrofolate-cyclohydrolase	gnl\|CDD\|184556	PRK14185, PRK14185, bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD.	1.27194e-166
NC_013037.1\|WP_015810719.1\|1443748_1444573_+\|1,4-dihydroxy-2-naphthoyl-CoA-synthase	gnl\|CDD\|180958	PRK07396, PRK07396, dihydroxynaphthoic acid synthetase; Validated.	0
NC_013037.1\|WP_015810722.1\|1446972_1447860_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|224017	COG1092, COG1092, Predicted SAM-dependent methyltransferases [General function prediction only].	2.71644e-31
NC_013037.1\|WP_015810726.1\|1451874_1452069_+\|50S-ribosomal-protein-L35	gnl\|CDD\|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	3.38205e-20
NC_013037.1\|WP_015810731.1\|1457707_1458526_+\|SDR-family-oxidoreductase	gnl\|CDD\|187616	cd05358, GlcDH_SDR_c, glucose 1 dehydrogenase (GlcDH), classical (c) SDRs. GlcDH, is a tetrameric member of the SDR family, it catalyzes the NAD(P)-dependent oxidation of beta-D-glucose to D-glucono-delta-lactone. GlcDH has a typical NAD-binding site glycine-rich pattern as well as the canonical active site tetrad (YXXXK motif plus upstream Ser and Asn). SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	2.01371e-137
NC_013037.1\|WP_015810728.1\|1452662_1455209_+\|phospholipase-C,-phosphocholine-specific	gnl\|CDD\|274561	TIGR03396, PC_PLC, phospholipase C, phosphocholine-specific, Pseudomonas-type. Members of this protein family are bacterial, phosphatidylcholine-hydrolyzing phospholipase C enzymes, with a characteristic domain architecture as found in hemolytyic (PlcH) and nonhemolytic (PlcN) secreted enzymes of Pseudomonas aeruginosa. PlcH hydrolyzes phosphatidylcholine to diacylglycerol and phosphocholine, but unlike PlcN can also hydrolyze sphingomyelin to ceramide ((N-acylsphingosine)) and phosphocholine. Members of this family share the twin-arginine signal sequence for Sec-independent transport across the plasma membrane. PlcH is secreted as a heterodimer with a small chaperone, PlcR, encoded immediately downstream. [Cellular processes, Pathogenesis].	1.29641e-145
NC_013037.1\|WP_083769047.1\|1451181_1451739_+\|translation-initiation-factor-IF-3	gnl\|CDD\|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	1.00573e-79
NC_013037.1\|WP_015810716.1\|1440530_1441715_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.15368e-13
NC_013037.1\|WP_015810727.1\|1452173_1452518_+\|50S-ribosomal-protein-L20	gnl\|CDD\|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	3.36247e-59
NC_013037.1\|WP_015810724.1\|1449127_1451071_+\|threonine--tRNA-ligase	gnl\|CDD\|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0
NC_013037.1\|WP_015810714.1\|1438736_1439429_+\|NAD-dependent-deacylase	gnl\|CDD\|238703	cd01412, SIRT5_Af1_CobB, SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity. .	2.46849e-108

>NC_013037.1|WP_015810721.1|1445025_1446606_+|hypothetical-protein
MTRNKRTVFRLVLPLLFLGLIGIQLLAQGVKRIELPLPGNTAYQAVPLGKQGVLLISKPDKGTFNVQKFDTNLERVWSIDGPIESNLDYIASSYDGQAVFLLFSKYRSSLYQIVKVNVGPGFVETFTINTVDRFEITDFKTLGYSVFMAGMVRNEPVLIYTQLTTQQTRVLPSAIKGSNAIQTVEVDTAQHLVNVCFAVKKGRQTKIVARSYEETGELYTQVSVDPEDDFSLLSGRLQVLNDSVRIVIGTYGYRNMQSSSVAASQGLYISKIVGDETVFTKYHSFTDFKNFFNFLSERQQEKMEKRIRKKKESGNDLKLNYRLLVHDIVPKAANFLLVAEVFYPEYRYQNPSMMGGFGYGYGGYGYPFGMGLYNPYLWNPMYGGRGYNSQVFDGFTYTHAIVADVDHNGNLNWDNSISFDNVKSMELKEKIKVQNFTNGNSKLIYSHNGAIKSKIIKGDQVIDSDRVIPNETYVDGDKVRKTSTDDIDYWYDNFYLAWGEQRIVNAAGDPQTRGRRNVFYLNKIAY
>NC_013037.1|WP_015810720.1|1444625_1445039_+|EVE-domain-containing-protein
MNHWLVKSEPFKYSWDHLVAEGEGMWDGVRNYAARNNLMAMKVGDPVLFYHSNEGKEVVGLAKVSKEHYPDPTTDEPGWVVVNVVPIEKFPNTVTLAQIKKDELLKQMDLVRLSRLSVVPVKREEFDHIVALAHDKK
>NC_013037.1|WP_015810719.1|1443748_1444573_+|1,4-dihydroxy-2-naphthoyl-CoA-synthase
MSSTVQWETIKEYEEILFTLHEGIAKISINRPHKHNAFTPLTVTEMIDAMHICREDPRIDVIILTGEGGKAFCSGGDQSVRGHGGYIGDDHVPRLNVLDLQKMIRSIPKAVIAMVAGWAIGGGHVLHVICDITIAAENARFGQTGPKVGSFDGGFGASYLARVVGQKKAREIWFLCDQYDAGEALQMGLVNKVVPLEQLETVTLEWAKKIQEKSPLSIRMLKSAFNAELDGQAGIQELAGNATLLYYLSEEAKEGQRSFLEKRKPDFSKFPKFP
>NC_013037.1|WP_015810718.1|1442483_1443551_-|AMP-binding-protein
MIWTTGKTLCKTQKRPRNPYFAQAYDFMEKWLGGAREFVLHTSGSTGMPKPITVTRAQLAASAAMTGKALSLGPGTRALVCLNVGYIAGLMMLVRGMELDWELTVTEPTANPLAGLDHADFDFVAMVPMQLQSILENSATSGQVDRLGKVLLGGAPVNHALAMQISDLAMPVYQSYGMTETVSHVALKALNGPEASELYVFLPGIQYGVDERGCLHISGAVTNGQTVQTNDLVEIHGNAFQWIGRADNVINSGGVKIVLDQIDQRIAAVFHHLNIGNAFFCWWEPDAKLGQKLVLVIENAMPEALTERLTAEIRSRVSTYENPKHIYFAKAFAKTQTDKIDKRATFQKLSDSSNG
>NC_013037.1|WP_015810717.1|1441717_1442491_-|hypothetical-protein
MDKNLQIPGQYIVRYQTAPVVPAPFAHFYTLKLDIQSEQDLRVDFDILYNDREELSDDEIYDEGFSKDDDYKWKGALPAVWINEFKEIFESSKTIRKREESEYEDFIEIELEENGKYVTIYPVDKERWSYFLQEMMQAIFETGGREKPFELTYLEIDSEGKTTIDLKASFGKKEFTLSKNAGATRKLHWDQLQKIMDTVYKAEFVADNATETRPTKRGKYLTAGDGLWYQMGVAVLETTSKSKDLAKIEALFNTLAK
>NC_013037.1|WP_015810716.1|1440530_1441715_+|helix-turn-helix-domain-containing-protein
MSIVSNNIKYLRRLNGLTQEQFARKIAIKRSLLGAYEEARANPNLTNLKNMAAAFGVSVDNLLKNDLRKLRETPEMSLPLTTSRQMTVSHSGLPQSTPTRTPGYTEPQPLSKIIETYQQPEQPLRQVSRQINLKPVGGEMQQPVQHFNAASPQALPFNQPGAAQQGAAQPNAAQPGAAQQEVFQQPNFQQPAPSRTAATYQQPAAVPAAAQPAGFPTFNNQYQSPQFNAAVEQPAQHFPTIQWVARNQQADYIANFQNPHYLNALPLFQLPNLPTGYYRAFESGEDFTYPGSILVGTFIRNWYDIKDGMQYVFLLRSHGLIYRNVFNQVKTAGTLLLTSDNASIADLEIPLQDVLEVWEVKAFVSVQMPVPQPSLERVAQLVDELQMELSQYRQ
>NC_013037.1|WP_015810715.1|1439429_1440311_+|bifunctional-5,10-methylene-tetrahydrofolate-dehydrogenase/5,10-methylene-tetrahydrofolate-cyclohydrolase
MQLLDGKAISSQIKSEIKAEVEQWVAGGGKKPHLAAILVGQDGASETYVASKIRSCEEIGFTSTLLRFEADITEAQLLEAVESLNNDPDVDGFIVQLPLPKHISENTVMEAVNPAKDVDGFHPINVGRMCKGLPAYISATPFGILEMLIRAGIETSGKHCVVIGRSQIVGLPMSILMQRNTFPGNCTVTITHSKTQNLKEICQSADILIVALGRPEFVKADYVKEGAVVVDVGITRVADATKKSGFSIKGDVDFNDVAPKASFITPVPGGVGLMTICGLLTNTFKAAKKEIYK
>NC_013037.1|WP_015810714.1|1438736_1439429_+|NAD-dependent-deacylase
MKKLVVLSGAGISAESGISTFRDHNGLWDNYRIEDVATPEAWIRNQELVLDFYNQRRKQAADVKPNAAHYALAELEKHFDVTIITQNVDNLHEIAGSTNVIHLHGELFKSRSTKDPRLVYQMTGWELKTGDLCELGSQLRPHIVWFGEEVPMMDIAVDVTEQADMFLVIGTSLAVYPAAGLVHYVPTRKRIYIVDPAKPDITLKSNMVFIQEKATTGMQTLIKKYLLPES
>NC_013037.1|WP_015810713.1|1436303_1438682_+|type-I-DNA-topoisomerase
MSKNLVIVESPAKAKTIESYLGQDFTVKSSFGHVRDLPEHDMGVDVEHGFQPSYEISSDKVKVISELKKLAKDAEVWLATDDDREGEAISWHLKEALGLPDNTKRIVFREITKTALRNAIEKPRTIDTALVDAQQARRILDRLVGYELSPVLWKKIRIGKSNLSAGRVQSVAVRIIVEREREIDAFKSKSSFRVTAHFDLGNGKVLNAELAKNIPTEQEAQQFLEKCVGAEFSIRNLEVKPAKKSPAPPFTTSTLQQEASRKLSFSVAQTMTVAQRLYEAGKISYMRTDSTNLSEEALDKSKQQITKEYGIDYYNRRIFKTKSESAQEAHEAIRPTDFSTLLGSSDRNEQRLYELIWKRAIASQMSDAQLERTTATIGISTTSEELVAQGEVIKFEGFLKVYLESSDDEGDEEQKGMLPPLNIGQILKLADMKATERFTRNPPRYTEASLVKKLEEMGIGRPSTYAPTISTILKREYIVKEDRQGFEREFKEITLANEQIKSKVNKEVYGSEKAKLFPTSTGMVVNDFLVSHFQDIVDYSFTASVEKDFDHIADGQLEWQQMIKNFYTPFQKKVAEAREEAIDKSLTSRELGEDPATGKKVSVRIGKYGPYVQIGDVEDEEKPRFASLQKGQLMETITLDEAFELFKLPRQVGFFEDKDMIVNVGKFGPYVKHDGKYYSLAKTDDPMAVTEDRLVEIIEEKRLQDSNRTIKEFAEDPEAKVLNGRYGPYIAFGKKNVKIPKGTEPASLTYEQVLKLAAETPDKPAGRGGARKPAAAKAPAAKKPAAKKAAKK
>NC_013037.1|WP_015810712.1|1433203_1435975_-|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase
MNIYQDYIKEIEERKTQGLHPKPIDSAELLGEIIAQIKDQANEYRDDSLKFFIYNTLPGTTSAAGVKARFLKEIILGESVVEEISPAFAFELLSHMKGGPSISVLLDLALGEDAEIAKQAADVLKTQVFLYDADTDRLKEAFKSGSEIAKEILESYAKAEFFTKLPEVPEEIKIVTFIAGEGDISTDLLSPGNQAHSRSDRELHGQCMITPKAQQEIKLLQEEHPDKSVMLIAEKGTMGVGSSRMSGVNNVALWTGKQASPYVPFVNIAPIVGGTNGISPIFLTTVDVTGGIGIDLKNWVKKTDEHGNVVRNENGDPVLEEVYSVATGTVLTINTKTKKLYNGEQELIDISKALTPQKKEFIRAGGSYAIVFGKKIQTVAAKILGIEPTPVFAPSKEISNEGQGLTAVEKIFNKNAVGVTPGKILHAGSDVRVEVNIVGSQDTTGLMTAQELESMAATVISPIVDGAYQSGCHTASVWDKKAQANIPKLMKFMNDFGLITARDPKGEYHSMTDVIHKVLNDITVDEWAIIIGGDSHTRMSKGVAFGADSGTVAIALATGEASMPIPESVKVTFKGSMKEHMDFRDVVHATQAQMLQQFGGENVFQGRIIEVHIGTLPADQAFTFTDWTAEMKAKASICISEDDTLIESLEIAKNRIQIMIDKGMENHKQVLQGLINRAEKRIAEIKSGEKPALTPDVNAKYYAEVVIDLDVIVEPMIADPDVNNKDVSKRYTHDTIRPISFYGDEKKVDLGFVGSCMVHKGDLKIVSQMLKNLEEQQGKVEFHAPLVVAAPTYNIIEELKSEGDWDVLQKYSGFEFDDNAPKVAARTEYENMMYLERPGCNLCMGNQEKAAKGDTVLATSTRLFQGRVVEDSERKKGESLLASTPVVVLSAILGRIPNISEYKAAVEGIDLTKFAPPIKTLSR
>NC_013037.1|WP_015810722.1|1446972_1447860_+|class-I-SAM-dependent-methyltransferase
MILLSPDQHTDYQLIDSGGFEKLEKFGPYVLSRPEPQAIWDKSLSEAEWDKRSNAVFKKDKNSQEKGQWITKGDMPDKWVFQYRTKELHLRTKLALSSFKHVGVFPEQATNWDFIARTLKQMPEDKPSVLNLFAYTGIASLAAKASGADVTHVDSVKQVISWSRENMDLSGLSNIRWVVEDALKFVQREVRRGNKYNGLILDPPAYGRGPDGEKWLLEESLNELLRLCAQLLKDKNFFFIINLYSLGFSALIVENLIKAHFGTEIKHEFGELFIPDSFGKKLPLGVFSRFSDQNV
>NC_013037.1|WP_015810723.1|1447866_1449066_+|tetratricopeptide-repeat-protein
MKPDNLKYFSIAILIALAGLEQSCESDARTSTRIPPVIKKGKEQWQKDALLSLTELINRGIDSDVNYFKRARIYFEREQYAEALDDINESIYEQDNVSEYFLLRGKINRELGNIDNALEDAQRAEALQQSSPELYVLLADILQAKNRFGEAAGYLNQALRMAPYDGSAYYVKGMLQAKQGDSLASLSSLNYAMNVNPRLLRAYEQGTIINLKLKNTAEALAINEKALNRFPERASLFYGRGEILNALAQPDTALIFYQKALAIQPDYDEALNALATVAMQQRAYPAAIPALKKLLRKKPQSKELNNMLGYAYEKSGELDLAKTYYTTSLTIAPGDQDARYGMYRIRKIESEGLYPSYYPEENTRDGYKLLDTSRVKINIIQPRGTTNIRVDSSRKAKIE
>NC_013037.1|WP_015810724.1|1449127_1451071_+|threonine--tRNA-ligase
MKDESQVKITLPDGSERFYPKGVTALEIALSISEGLARNVIAAKVNNEVWDPTRQITEDSLVKLLTWNDEDGKATFWHSSAHLLAEALEALYPGIKFGTGPSIEKGFYYDVDLGGQTISQEDFPKIEAKMLELARQKNEYIRKPISKAEAIDYFTQKGDEYKLELIDGLEDGSITLYEQGSFTDLCRGPHIPNTGFIKAAKLTNIAGAYWRNKQENKMLTRIYGITFPKQKELEEYVTLMEEAKKRDHRRLGKELELFAFSEKVGQGLPLWLPKGAMLRERLQAFLSKAQSRAGYVPVITPHIGSKDLYVTSGHWDKYGKDSFQPIKTPNLDEEYMLKPMNCPHHCEIYKTSPRSYKDLPLRFSEFGTVYRYEQSGELHGLTRVRGFTQDDAHIFCRPDQVKEEFIRVIDLVLYVFKSLGFNDYSAQISLRDPNNKEKYIGKDEDWEKAESAIIEAAAERGLSTVTELGEAAFYGPKLDFMVRDALGRKWQLGTIQVDYQLPQRFQLEYTGSDNQKHRPVMIHRAPFGSMERFTAILIENTAGQFPLWLSPDQIAILPISEKFADYAEEVFFQLQDHDIRGFVDHRDEKIGRKIRDAEVTKVPFMLIVGEKEAAEGKLSVRRKGEGDLGSMTIEEFAAFFKKEASIA
>NC_013037.1|WP_083769047.1|1451181_1451739_+|translation-initiation-factor-IF-3
MALRPPSGRMRIPEEPYKINERITAKEVRLVGENIEPGIVDINTARAMAKAQGLDLVEIAPTAVPPVCKVVDYSKFKYEQKKKQKEIKAKAQKVVIKEIRFGPNTDDHDFDFKLKHATNFLKEGSKVKAYVHFVGRTIVFKERGVNLLKKFSEALSEYGKLEMEPKLEGKRMTIILAPAPAKGAK
>NC_013037.1|WP_015810726.1|1451874_1452069_+|50S-ribosomal-protein-L35
MPKMKTNSGAKKRFALTGTGKIKRKHAFHSHILTKKSNKRKRGLVKTGLIDESNEKQVLAMLRK
>NC_013037.1|WP_015810727.1|1452173_1452518_+|50S-ribosomal-protein-L20
MPRSVNHVASRARRKKVLKLAKGYFGRRKNVWTVAKNAVERGLAYAYEGRKQKKRNFRALWIQRINAGTRQHGLSYSAFIGKLNAKGIELNRKVLADLAMNHPDAFKAIVDQVK
>NC_013037.1|WP_015810728.1|1452662_1455209_+|phospholipase-C,-phosphocholine-specific
MDSRREFIRKATMLTGAAGLFSTLPASIQKALAINPPKGTTWKDAEHVVILMQENRSFDHSYGTLRGVRGFNDPRAITLPNNNLVWLQTNAFGETYVPFRLNMKESKATWMGSLPHSWPNQVDARNGGKYDKWLIAKQPGNKDYAKMPLTQGFYNREDIPFYYAMADAFTVCDQNFCSSLTGTTPNRLYLWTGTVRENTDPDKHYANIRNENVTDDREAKWTTFPERLEDNGVSWRIYQNELSINTGFTGEEDSWLANFTDNPIEWFTQYNIRYHTGYQRYLKERQQMLPGEIEQAQAKLKTLSGKEANDLEKILKEKRALLKLANEELIRWSAEKFEKLSQREKNIHNKAFTINKNDPDYRKITTIKYHDGDIEHEAKAPMGDVLYQFRSDVKTGSLPTVSWLVAPENFSDHPTSPWYGAWYVSEVLDILTANPEVWKKTIFILCYDENDGYFDHVPPYVVPDPYKEDTGAVSAGIDCKTEFVTLEQDMTKKAKKDSRESPIGLGYRVPLIVASPWNRGGNVCSEVFDHTSILQFLEKFVSLKSGKEIKETNITEWRRTICGDLTSTFTPYDGQELKLPTFLERTEFMESIFNAKFKKLPNGYKALTKSQIDEVNANPLTSPILPNQEKGTRPACPIPYELYADCAFNSAKNAFEINLEARNGIFHDKSAGSPFIVYAPGKYKNEQMKVWNYAVKAGDALTGSWNVGDFENQRFHLKAYGPNGFFREYSGDKENASVKIECAYQLNRSKKPTGHIELKISNLHSSQKCSLTLTDNAYGAAAQKITLEKASTGAKSQKTIVLNLAKSFNWYDFTVAVEGVEHAFSRFAGHVETGAESQSDPFMGQMIS
>NC_013037.1|WP_015810729.1|1455386_1457306_+|molecular-chaperone-DnaK
MGKIIGIDLGTTNSCVAVMEGNEPVVIANSEGARTTPSVVAFMDNGERKIGAPAKRQAITNPKHTISSIKRFMGKKYDDTTSEMKTVAYSVEKGPNNTPRIPIGDRLYTPQEVSAFILQKMRQTAEDYLGQEVTEAVITVPAYFNDAERQATKEAGQIAGLDVKRIINEPTAAALAYGLDKQHKDMKIAVFDLGGGTFDVSILELGDGVFEVKSTDGDTHLGGDDFDQVIINWLADEFQKDENVDLRRDPMALQRLKEAAEKAKVELSSSTQTEINLPYIFPVDGIPKHLVRTLTRAKFEQLADTLFQRMMEPCKRAMKNAGYSNSDIDEVILVGGSTRIPRVQEEVEKFFGKKPSKNVNPDEAVAVGAAIQGGVLTGEVKDVLLLDVIPLSLGIETLGGVFTKLIEANTTIPSKKTETFSTAADNQPSVEIHVLQGERPQASNNRTLGRFHLSDIPPAQRGVPQIEVTFDVDANGILHVSAKDKGTGKEQKIRIEASSGLTDAEIARMREEAKANEAADKAEREKIEKINGADSLIFSTEKQLKEYGDKLSDSNKSSIEAALAELKTAHQSQDLTAIDAASEKLNAAWQASAQEMYAQGGEQPGGQPGAGGPTGNPGAGAGNSGSTDDVTDVNFEEVK
>NC_013037.1|WP_143828895.1|1457525_1457711_+|hypothetical-protein
MYLSPTTREKAVAVAQELLRSTNISPREAVSKAILIAKNWAVKNVNRRVWKKLKSVEKEMI
>NC_013037.1|WP_015810731.1|1457707_1458526_+|SDR-family-oxidoreductase
MNDLKFKDQVVIVTGSSSGIGKACAVHFGNNGANVVVNYSSNAEAGQEVVDQIKSNGGNAILVKADVSKEDEVKALFAETVNQFGRVDVLVSNAGLQKDAPFLEMTLEQWQKVIDVNLTGQFLACREAAKQFIAQNQSATEVTHSELAIGKIILMSSVHDVIPWAGHVNYAASKGGTMMFMKSISQELAPHKIRVNSVSPGAIKTPINQDVWSDPDKYQSLLQLIPYKRIGTSQDVAKAVAWLASDDSDYVNGETLYIDGGMTLYPEFADNG

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Crispr_ID: NC_013037_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013037_5

1681373-1681480

Orphan

Consensus_repeat	Method
TATAGAAAATCGGCATTTTCTATACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013037_5

>merge|NC_013037|5|1681373-1681480|CRISPRCasFinder
TATAGAAAATCGGCATTTTCTATACATATCGCAAAAACATGTATAGAAAAGTGCCGTTTTCTATACATATCCAAAAAACATATATAGAAAAGCGGCATTTTCTATACA

>NC_013037|5|5|1681373-1681480|CRISPRCasFinder
TATAGAAAATCGGCATTTTCTATACA	TATCGCAAAAACATGTATAGAAAAGTGCCGTTTTCTATACATATCCAAAAAACATA
TATAGAAAAGCGGCATTTTCTATACA

Protein	Signature genes	Signature genes Name	Protein_function
NC_013037.1\|WP_015810919.1\|1670354_1671428_-\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|240081
NC_013037.1\|WP_041734783.1\|1679786_1680368_-\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|274376
NC_013037.1\|WP_015810917.1\|1669394_1669751_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_013037.1\|WP_015810929.1\|1686392_1687247_-\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NC_013037.1\|WP_143828906.1\|1668617_1669142_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_013037.1\|WP_015810930.1\|1687491_1689279_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015810918.1\|1670087_1670237_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015810923.1\|1678696_1679683_-\|DUF4974-domain-containing-protein	unknown	unknown	gnl\|CDD\|226235
NC_013037.1\|WP_015810935.1\|1693791_1696164_-\|glycoside-hydrolase-family-95-protein	unknown	unknown	gnl\|CDD\|379625
NC_013037.1\|WP_015810920.1\|1671767_1672832_+\|ribosome-small-subunit-dependent-GTPase-A	unknown	unknown	gnl\|CDD\|234988
NC_013037.1\|WP_015810932.1\|1689825_1692060_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	unknown	unknown	gnl\|CDD\|224446
NC_013037.1\|WP_015810915.1\|1667465_1668563_-\|FecR-family-protein	unknown	unknown	gnl\|CDD\|377406
NC_013037.1\|WP_041734784.1\|1692066_1693074_-\|xanthine-dehydrogenase-family-protein-subunit-M	unknown	unknown	gnl\|CDD\|224238
NC_013037.1\|WP_015810928.1\|1683737_1686113_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_013037.1\|WP_143828907.1\|1674935_1678010_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NC_013037.1\|WP_015810926.1\|1681482_1682361_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|131350
NC_013037.1\|WP_015810927.1\|1682466_1683702_-\|DUF4374-domain-containing-protein	unknown	unknown	gnl\|CDD\|373002
NC_013037.1\|WP_015810931.1\|1689354_1689795_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_041736039.1\|1693070_1693691_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224991
NC_013037.1\|WP_015810921.1\|1673130_1674915_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630

Protein	Function_ID	Function_description	E-value
NC_013037.1\|WP_015810919.1\|1670354_1671428_-\|nitronate-monooxygenase	gnl\|CDD\|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	9.81061e-76
NC_013037.1\|WP_041734783.1\|1679786_1680368_-\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	2.21668e-40
NC_013037.1\|WP_015810917.1\|1669394_1669751_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	6.18615e-20
NC_013037.1\|WP_015810929.1\|1686392_1687247_-\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	3.84533e-17
NC_013037.1\|WP_143828906.1\|1668617_1669142_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.57862e-17
NC_013037.1\|WP_015810923.1\|1678696_1679683_-\|DUF4974-domain-containing-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	2.59871e-21
NC_013037.1\|WP_015810935.1\|1693791_1696164_-\|glycoside-hydrolase-family-95-protein	gnl\|CDD\|379625	pfam14498, Glyco_hyd_65N_2, Glycosyl hydrolase family 65, N-terminal domain. This domain represents a domain found to the N-terminus of the glycosyl hydrolase 65 family catalytic domain.	8.04267e-76
NC_013037.1\|WP_015810920.1\|1671767_1672832_+\|ribosome-small-subunit-dependent-GTPase-A	gnl\|CDD\|234988	PRK01889, PRK01889, GTPase RsgA; Reviewed.	5.50051e-122
NC_013037.1\|WP_015810932.1\|1689825_1692060_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	0
NC_013037.1\|WP_015810915.1\|1667465_1668563_-\|FecR-family-protein	gnl\|CDD\|377406	pfam04773, FecR, FecR protein. FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm.	9.59478e-15
NC_013037.1\|WP_041734784.1\|1692066_1693074_-\|xanthine-dehydrogenase-family-protein-subunit-M	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	1.78088e-81
NC_013037.1\|WP_015810928.1\|1683737_1686113_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	3.41031e-35
NC_013037.1\|WP_143828907.1\|1674935_1678010_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_013037.1\|WP_015810926.1\|1681482_1682361_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|131350	TIGR02297, AraC-type_DNA-binding_domain-containing_protein, 4-hydroxyphenylacetate catabolism regulatory protein HpaA. This putative transcriptional regulator, which contains both the substrate-binding, dimerization domain (pfam02311) and the helix-turn-helix DNA-binding domain (pfam00165) of the AraC famil, is located proximal to genes of the 4-hydroxyphenylacetate catabolism pathway.	2.3445e-19
NC_013037.1\|WP_015810921.1\|1673130_1674915_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	1.28697e-61
NC_013037.1\|WP_041736039.1\|1693070_1693691_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	1.33309e-79
NC_013037.1\|WP_015810927.1\|1682466_1683702_-\|DUF4374-domain-containing-protein	gnl\|CDD\|373002	pfam14298, DUF4374, Domain of unknown function (DUF4374). This family of proteins is found in bacteria. Proteins in this family are typically between 406 and 466 amino acids in length.	3.21466e-45

>NC_013037.1|WP_041734783.1|1679786_1680368_-|RNA-polymerase-sigma-70-factor
MNHPYSSYTEQTLMTLICEQDEELAFRELYRRHVRLLVHTAIRKTGRKAIAEDLVQETFVKFWLGRHKFDIQKNIQAYLNGTLRHCIINYYHQEQRKQISTLEEDDFVPDNVTAEDLDFNTLNEFYEQSLLKLPEKCREVFSLSRKGYSLKEIAGQMEISEKTVEAHISKALKILRVEMKDYIALAVLMLPVI
>NC_013037.1|WP_015810923.1|1678696_1679683_-|DUF4974-domain-containing-protein
MEKPPLPPEIFRKYLANKCTDEERRLVNKWYQQLDQPADEAFTDADEARLFNRIKSYLSELRRNDEPAEPVSSLWHYVGRVAAVFVLGLGILYFLYQKPERIVEQRRGATVGWVTFTNTKARIVPYVLPDSSVIWLHPRAEVRWAEPFAARNVHFSGEGFFDVKRDPERPFVIHSGDLQTRVLGTSFNVRAIPGEATVKVSVATGRVEVSDAAKRTSVVLKPEQEAVFEPKSKHLAVQAVQEKESDKEIWQAASLVFNETPMTEVAERLMQTFQVKISFANDGLADCRLKVDFTNQRLPEILDMIDTLLGSTYRIDGDSITLKGQGCR
>NC_013037.1|WP_143828907.1|1674935_1678010_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MLAAADRTVKGTVTSPETNEPLPGVSIILKGTQRGTTTDAAGKFQLDVPDENATLIFSFVGYLSQEVVVGNRTDISIALQLDTKALDEIVVVGYGTQKKSTLTGSIAAVKGSEIAENPVPNISNSIAGRVAGVSMRPNGGQPGNDSPEIHIRGIGTTGNNKPLVVVDGVIRDNINQIDPSSIETVTVLKDAAAVAPYGLGGANGVLLITTKKGASGAPTLTFGAYYGSQTPTYYPKLLSAQDYMRLKNEAYRNENPTGTQLPFATDLVENYVNLNREDPDKYPISNTKDLVNMNAPMQNYTLQLSGGSERIKYQTGFGFLKQNGMFDPVKYMRYSYNMNLTAEATKTTTVSLSLIGSVERVSSVDTAVSAGNLFRNGFKYIPIRALYYSNGLWGEFAGNSPVGVLNAGYTKNSNNTLLTTIGIEQKLPFIKGLSIKGTFSYDPSQRTKKGYHKPFYYYTQDLTTTPYTYKREISTAEGGAAAFSWLAQQFIKTQTFTYQGYLNYHNTFGKHDFTGLIVAEARNNTYELFSARRNNFAVDVDELNMGSSNKNDFDNGGTSSTGSQIGYVYRVGYAYAGKYLLEASGRYDGHYYFAPGKRWGYFPAFSAGWVISEENFLKNGFNWVDNLKLRGSWGKSGNLAGTAFQYLTGYNLNGNAYAFGPGSMVQGAVVPNEANKNITWEISTKTDIGLEASLWRGLLTIEADYFHEKRTGMLLPPAVSVPVEYGLALADENGGIMENNGVELSLGTQYRFQNDLRLGINGNVSYAKNKMIKVFETAATRNNPNRSRTGRALGTQFGYKTDGLFTTDDDKNDDGLINSADGYNVTQFGALRPGDIRYVDVSGPQGVPDGKIDSNDEVMIGKPVYPLLTYGLNATADWKGFDLNLFFQGSSLASLDIRQFQTIPFNNNNSNSSYEYYDNRWTPETQDARYPRATQAPYANNTQLSDFWMTSTAHLRLKNAIVGYTLPKSITQAIRIQNVRVYASGQNLLTFSKLKFMDPEVGYTDRETAYPNQRVYVFGLNVTF
>NC_013037.1|WP_015810921.1|1673130_1674915_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKRIKHTISLAVLALGLFTTGCNEDFLENDIKSRLTDDMQWSSEGNADLFLNDIYAVLSNKWNSPDNLDNFTDDNDAGFYWKSYSWRQGIVDPAVNNGTPMDHANGNATDYASWAAGFLKIRKCNLFIQKVTENAANFSEAYRKKRIDEVRFMRAYYYSELFMHLGGLPIITEVLDRNTMSEEELYRPRATFEETFNFIIKELGEIVANKALPVKYNNGDADAGRATLGAALALKGWLELYAASPAFNAATPAAGTDPNKLVGFGNFDPKRWATAAATNKQFMDTFGGTYALFPDINAFWWEKNEYNSEVIWDRQVVAVIMGSNYEQYGGPVWIDGVYYTWGNYCPTQELVDQFAMANGKPISDPASGYDPQNPYVNREKRFYDFIVYDGAPYKQDWMAKTDTIYTRIDKVRPSKNQIDFGTDDVGNTGYYFKKKINPLKPRGGAASGQNYVYYRYAEVLLNYAEAQNEAAGPDASVYSAVNAIRKRSNLPELPAGLTKETMRQAIRRERRVELCFEAKRFYDIVRWVIAEDVMNKDFHGMKITNTSPNDNKGKWVYEVVGLNHPHVFTKKMYMNPVPQPVVDQNKKIIQNPGY
>NC_013037.1|WP_015810920.1|1671767_1672832_+|ribosome-small-subunit-dependent-GTPase-A
MTSLTSYGWNPHFEQHFHTFQSQGLEPGRVTAIEGFRHRLVSASGQVDALLSGALMNGANHWELPKVGDWVAFKNYDNEGIIISVLPRANELSRKMPGRTTEKQVIATNIDTAFIVQGLDRDFNPMRLQRYIVQIMQCNIRPVVLLNKQDLVADPEYYRQQVTALGYECPVLLLSATGREGLQQWANEQLLPGQTYVLIGSSGVGKSTLVNALLGYRLQEEGSVSDFNHKGRHTTVSRNLVMLPSGAMLIDSPGMREFGVTLDADDQGMHYHPLLAALAADCRFHDCTHLHEPGCAITAAVQSGELPREVYDSYLKISREQAHYQGDSIEKKRAERQFGKMAKQVVQYRKQRKY
>NC_013037.1|WP_015810919.1|1670354_1671428_-|nitronate-monooxygenase
MWNQTRVSRTLGIEYPILQGPFGGNLSSVKLVSTVSNLGGMGGYGAYMLTPNEIVALDKELKEATAKPYNINLWVSDSDQTSGEVSEEAYEKAAALVKPFFDELGAPLPAKPKAYPSRFENQVEALLATRPPVFSFIFGVPSQTILDDFRKKGIKLIGNATTLDEAIALENAGVDVIIASGFEAGGHRPSFLESAEASLTGTFVLVQQIREKVKTPVVAAGGIADARGMAAALTLGAEGVQIGTAFLATEESGASEYHRNLLHSDAARYTTLTKVSTGRLGRGIRSRFTETLAGRNDELLPFPLQNQFIVPLRKAATEKQQYDLIMFWGGQIAPNLKHTSAKKLFETIVEEVPVFLR
>NC_013037.1|WP_015810918.1|1670087_1670237_+|hypothetical-protein
MIDFKKMDEKDFVFLDKKLSDKEQKAFSEFLKSQKSSSSKSAAVRTVHQ
>NC_013037.1|WP_015810917.1|1669394_1669751_+|helix-turn-helix-transcriptional-regulator
MRKLTSTNYYNQTFLEEKCTLNELINLLSKRWLTEVMFSIEEGNNRFSTLKEDLKHISDNILADRLRLLEQHKLIIRNDNFREVPSRVEYSLSETGSKLSELLDGLCHFSETEMEFPE
>NC_013037.1|WP_143828906.1|1668617_1669142_-|sigma-70-family-RNA-polymerase-sigma-factor
MYALANIMQGYYADLFHWGLRLHGEREFVKDCIQDMFVNLWRMQQSSGAEVKGPAGVVTNVRSYLLVSLKTRILRELSKKHVTHQSMLSDEYSFSVEFSSDLRLIDEEHEIYQVRKLEGILNSLSGRQKELIYLRFYQSLSFEQIAEVMNLSRQSVYNLLQKSLGSLRKHYHVS
>NC_013037.1|WP_015810915.1|1667465_1668563_-|FecR-family-protein
MKPYELYTVEDFLEDEHFREWVQGRGTQEVFWLAFRERYPAQQEAFRQAEHIIRAAHVEDSRISEREIRAEVERFIGQSGAQEGDLEFSFPDDDDDAGRSIFWKRWLIAAAAVLVLGAGIGWHYYQTNHTAPGIATADTSPPNLVTTRNDTDKTLKISLNDGSEVILSENSSLRYPSEFEDGARVVYLTGEALFSVKKQGQTFMVHTGKVVTKVLGTRFVVSAFDDDREIRVQVQTGKVSVYVDKPSEKEVKGLIITANQAAVFEKSANQLSKTVVENPERLPDGPVESILKYDEVPLPVILRDIEKLYGIPVQFDADSFWTCKITVAFSDESMYDKLSILCKTVSAGYEVVDGQIIVSGQGCSK
>NC_013037.1|WP_015810926.1|1681482_1682361_-|helix-turn-helix-domain-containing-protein
MEYTGNRANERPHEPQRSEFPLHDLGDDFFAITTIEDGDEHFFNGVHRHDFYEVLWFTDVEPGQAHYIDFNQYPIARNDLFLLLPDQVHSMDQREKRGFVMAISKDFFERFIGSDIFKLFRYSANFTVTIPDSRLPVMNALMTLIRTEYEDGKRPAILESYLRSWFLHCFDLQKEAGDAAPRDARLQMLLESIELNYRRQRKADFYANELSLSAKRLNELTRGSFGKTISQIINDRLVLEAKREIGYLRKPIKEISYELGFSEPSYFTRFFGKQTGLAPEDFRKKIAALYEG
>NC_013037.1|WP_015810927.1|1682466_1683702_-|DUF4374-domain-containing-protein
MKKSYLKWFFVVGMGAFLGACSDDDNNTTPTPEPGNGTQSRYVVASAPIGSQGVADYLLTTSDLSQGTISTVGQGIEQDGSYRYYLTHKGKFFSLLYGQGNPGAVTTYALDEKGALVKTSDFQSETVQVFAPAGDDILTIKVPRSGNESASWFRINADQSKIVGEGQTNIVKLAGNGERAHFTWATQVGDKVFAPYMCIKGAAPDVFGTAYPDSSWIAVFNYPAMTLEKVIKDNRTSYIGAYFNNGLAVDENGDVYGFSPAAATNSGTLTSTKPSAFVRIKKGTTEFDQSYFFNVQEKSGGYKIANQTYLGSGKFLLYMYGDQGKASGAKKLAIADAYNQTFTWVTGVPDVIASSSASYNNNTISDDKKSVFVGINTEAGSWVYTVDIATATAKQGLKVEGGAITAIVKVK
>NC_013037.1|WP_015810928.1|1683737_1686113_-|TonB-dependent-receptor
MQISKILHTGLLCALSFVAFAQQADVTLTGHVRSEDGETLPGASVSLKGTSNGTFTNADGQYTLEHVRPGSYKLLVSFMGYETQTKDITLKAGEHFKYNPKLVSETRELESVSVIGRTETKEINRQAYNVTAIDAKKLQNSTLDLSHALDRVSGVRVRESGGVGSNMNFSLNGFTGRQVKFFLDGVPMDNFGSSFQLNNIPINLAERVEVYKGVVPIWLGSDALGGAVNIVTNTRQNSYLDASYSYGSFNTHRTTINAGFTAKNGFTAQLNAFQNYSDNNYWITVDVADVNTGEYFRNQRLRRFHDTYHNETVIANVGVVGKKFADRLLVGVTLGKNKAEIQTGARMVSVFGQWHRKGNIVMPSLKYSKKDLFVKGLSVNVSANYNLGQEQNVDTVYRRYNWFQQFKQYEGKGSERERSLYKFRNNNGLATANVTYQIDPRHSITINNVLNTFNRKGEDELFPESARYEQPRVNRKNVLGVGYKFDYSERWNTSLFVKHFSQNNKFSVSYNPTGNWGDEAFMVQKNSFEKLGYGVASTYFLFKNFQLKGSFEKSYRLPETDELFGDLLNLEGNIELDPETSYNYNLGFSYNGAINRAHRFSVDANVLYRDAQGFIRPRLNANQTKQVMDNLADVTNFGIDGEVRYSFRQLLTAGVNLTYQNLRNNTRFEEGYTTESPLYRDRIPNMPFLFGNADAAVFFKDLGKKGNTLTLGYNLLYVHAYYLYWPSLGSDKLDIPEQLSHDVNVVYAMADGKYNVSLECKNLLDAKLFDNFSLQKPSRGFYVKLRYFISK
>NC_013037.1|WP_015810929.1|1686392_1687247_-|sugar-phosphate-isomerase/epimerase
MKIKHLTLLAAMACGYTALAQKGKPLFPDQPGMVSYTYRASLSKDVAATLDTIKALKVTDMEFSSLFGKKAPEIRKMLDERGMKCSSFGVSYDDALNKTQEVGNNAKALGASYVRVAWVPHKGPFTLEMAQKTVADFNKIGKQLKDEFGLTFCYHNHGYEFEKHGDGTLMDYIIQNTDPKYVSFELDMLWTYFPGQDPAALISKYPDRFKLMHMKDLKKGITGNMSGGTPVENDVALGTGQIDIPSVLKAAKKSGIKHYYIEDESPSYATQVPQSIAYLKSLKY
>NC_013037.1|WP_015810930.1|1687491_1689279_+|hypothetical-protein
MNLAVFTLLSVGVGSTALWAVRLHRAKTHRPATAKYAVSGSLELRHVLFVVAFAAPALLFFIVWGVNAVNIPFQDDIDAILESTAIVAQGPGSFSELWLVLSKQDDERRIVVVRLAACLLYWATGSVDFRILAFAGLCSYLVFLRMIFLWFKAQRDLSLALLLPVPYLLFSNYNYEALYWSIIPLQQIAVFIWGFASIWMASRNTKVGLACGIGFGILAIYSDVSGIFVGPVVALMLFARRDGLSAMVWILLIGLVTTYYFSELTIPDYRPTTAQNLSSWRDMLLMMVAMPGMITDVMIDQSASSRLAGAAVAGLVSLLFVGGSAFVFWKKLMRAPTTITPGEWWLAGCILFLLITFFALAFGRAAFGAHNILISRYKHIFTFWAIFNYLLLLRLPIFRRVLGRWLLVVQAVAVIYCAGSYFQTWGEMMFFRKTIQADAYGWTRNREFPSAPIYLSVKRTVDAIFENALKNRVYQFPNLPFDDLQHADVRGSSDVIVRTTDFIVVGAQAPELRCSPDDGIYLIIHTSDETHVLPMRMRKNSFLCFLRTARYYSSYCESMGMLRQYLSKNKKYNLTLGVISGPNRYLLTTGKKVTG
>NC_013037.1|WP_015810931.1|1689354_1689795_+|hypothetical-protein
MRNNLITGKPWLPLLLTCSIVALIAWIRRGLVADVQLYDTYFVFEIHLLAGILITIMLVTSLLYRLTSRRNGLRQLTAAHVLGTIGLAIYIVSSAGHAPEQANITMSFAEYKAWQDANARFAMALVALGSVQMLFVANLIAKWVKG
>NC_013037.1|WP_015810932.1|1689825_1692060_-|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit
MTRQPMDDPSDSSLSRVDGAAKVTGTATYSAEYAIPGLAHAVLVTSTIAKGSIKDIESREAAAAPGVLAVISHVDAVEVPGWPARKQPAERAPTGTALRVFYDPLIYFDGQPVAMVVAGTREQAVHAASLVRVTYQQEKHQTHFEKNTQKAVVPQNVQRSKSSPFQDYDRGDSAGLNQAHTKIEAEYTIPTQHHQPLEPHAIIAVWEAEDKLTVYDKNQGVKSVQGQLAQAFKIPRENVQVVAKYIGGAFGSGIRVWPHTMAAVMAARHLKRPVKLVLGREQMFTSVGYRPYTVQKISMGAAADGRLLGIVHEGTGQTSMYEEHLERTVLASRALYACPHVATRYRLLPLDVSTPTWMRGPGDATGMFALESAMDELAFALKMDPLELRLKNYAETDPERNLPWSAKSLKACYELGAGKFRWHDRRMEPASVRRNGKLVGVGMASSLYGYHRHPSRARAVLHADGSVTVSSATMDIGPGTGTAMTRIAAKVLGLEAKKVRFELGHSNLPDAPGQNGSSTIPSVGSAVYVTCEALKAKLLALASEMPEGRSMGPMVVREGRVFGSTGGQTGIAFSEILKYHRLDSLEAMEESKSGAERDQYSMYSFGCHFVEVEVDPLTCEVRVTRVVTCADVGAIINPKTARSQSIGGVVGGIGMALMEHSQMDHRFGRYVTTDFASYHIPVHADVPPIEVYYIDKPDPHANPIGSKGLGEIAIVGVASAIANAVFNATGKRIRTLPITPDQLV
>NC_013037.1|WP_041734784.1|1692066_1693074_-|xanthine-dehydrogenase-family-protein-subunit-M
MRPFQYLRPKTVAEAVTMAGDNPEAQYIAGGTNLIDLMKRGVTSPAKLIDINHLPLRKIEHRNDRVRIGALALNSDVAEHRLIQTRQPLLAQALLAGASGQLRNMATVGGNLLQRTRCSYFYDLALPCNKRKPGSGCGAEEGINRTHAIFFAGNGFGGIEKSSCLAVHPSDMCVALTALETTVVVNGPDGERRVMMKDFHRLTTQQPELDTNLRPGELITAIEVEDNAFARHSHYLKVRDRASYAFALVSVAAALQIDGGKIWDARMALGGVAHKPWRYWAVDLMLRGQAPSEKLFREVAEHEMKSAKATEQNAFKIRLTSNAIVAALKLAAGIS
>NC_013037.1|WP_041736039.1|1693070_1693691_-|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MAIDNEASPDAENENRRFFLKQSIAIAGLSIAPSGLLHSAPDDGPVGNAVKVTISLMINSKRRRLSVDPRMTLLDLLRENLGLTGTKKGCDLGQCGACTVHVDGRRTLSCLSFAVMQHGRKITTVEGLSNGDQLHPLQEAFVKHDGFQCGYCTPGQLMSGVACIREGHAGSAESVREYMSGNLCRCGAYPNIVDAILEVKKAGTKV
>NC_013037.1|WP_015810935.1|1693791_1696164_-|glycoside-hydrolase-family-95-protein
MHNTLLSSLSLLLFAATALAPLQAQPTSKTAPLSLWYDQPAKEWMTQALPIGNGHVGAMFFGGTDEERIQFSEGSLWAGGKGANADYNFGIKKEAHKHLPEVRELLAAGKLKEAHALANKELTGAIHEKKENTPSSDFGAQQTVGDLFIKMPSKGAAQNYRRELNISDALGKVQYEAGGTRFERSYFGNYPAKVMVYRFTSSTPETYSIRFETPHAKDYERFEGKQYTFGGHLKDNHQEFETVYRIDTDGKTAFSDGVLTVTGARSIVLIHTVATDYVMKFPDYKGNDYKKANAATMAGVAGKNYASLVAAQQKDYHSLFDRVALTLGNADAPAIPTDQRQKAYSAGQADGRLEELYFQYGRYLMISSTRPGTMPMSLQGKWNDSTNPPWANDYHTNINIQMLYWPAEVTNLSECHVPLMDFTQSIVAPGRLAAKEFFNAKGWIVNTMLNAYGYTSPGWDFPWGFFPGGAAWLSQHLWEHYAFTNDKAFLKNTAYPIMKEASEFWMDYLTDDGRGRLVSSPSYSPEHGGISTGATMDHEMAWDVLNNTAEAAAILGVDQDFAQKARSTRDKILPLQIGRWKQLQEWREDVDDSTNHHRHVSHLFALHPGKQISNAQTPAEAEAARVSLNARGDDGTGWSLAWKVNFWARLQDGNRAHKLFKSVLRPVASQGTNMADGGGSYANLLCAHPPFQLDGNMGSTAGVAEMLLQSQTGVIELLPALPDAWPTGSVKGLKARGNVTVDEVWENGKLKTVTLTSATAQKRVLKYGSKTIDAALAAGKAKTWTANDFR

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Crispr_ID: NC_013037_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013037_6

1722274-1722397

Orphan

Consensus_repeat	Method
AAATGCCGTCAGGCATGCAATATTGGTAGCAAAAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013037_6

>merge|NC_013037|6|1722274-1722397|CRISPRCasFinder
AAATGCCGTCAGGCATGCAATATTGGTAGCAAAAAGTCCCACATCCAAAGCGCCACGAATGCTGTCAGGCATGTAACAACATGCGCGCAAATGCCGTCAGGCATGCAATATCGGTAGCAAAAAG

>NC_013037|6|6|1722274-1722397|CRISPRCasFinder
AAATGCCGTCAGGCATGCAATATTGGTAGCAAAAAG	TCCCACATCCAAAGCGCCACGAATGCTGTCAGGCATGTAACAACATGCGCGC
AAATGCCGTCAGGCATGCAATATCGGTAGCAAAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013037.1\|WP_015810947.1\|1715339_1715912_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|223734
NC_013037.1\|WP_015810946.1\|1714175_1715210_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378890
NC_013037.1\|WP_015810952.1\|1721038_1721932_-\|TIM-barrel-protein	unknown	unknown	gnl\|CDD\|366542
NC_013037.1\|WP_015810956.1\|1728994_1729810_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|131350
NC_013037.1\|WP_015810955.1\|1726450_1728895_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|379720
NC_013037.1\|WP_015810957.1\|1729942_1730476_-\|YceI-family-protein	unknown	unknown	gnl\|CDD\|377274
NC_013037.1\|WP_015810944.1\|1712266_1713037_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_013037.1\|WP_015810958.1\|1730723_1732256_-\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379232
NC_013037.1\|WP_015810948.1\|1715973_1716396_-\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176906
NC_013037.1\|WP_015810945.1\|1713033_1714134_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NC_013037.1\|WP_015810951.1\|1720312_1720651_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|163261
NC_013037.1\|WP_041736044.1\|1711300_1712038_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_013037.1\|WP_015810950.1\|1717695_1720065_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274576
NC_013037.1\|WP_015810949.1\|1716516_1717554_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274817
NC_013037.1\|WP_143828685.1\|1739118_1739742_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_013037.1\|WP_015810961.1\|1737929_1739030_-\|FecR-family-protein	unknown	unknown	gnl\|CDD\|377406
NC_013037.1\|WP_015810953.1\|1722790_1725187_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_013037.1\|WP_015810959.1\|1732344_1734123_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630
NC_013037.1\|WP_015810960.1\|1734149_1737719_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|274948
NC_013037.1\|WP_143828908.1\|1725254_1726430_+\|DUF4374-domain-containing-protein	unknown	unknown	gnl\|CDD\|373002

Protein	Function_ID	Function_description	E-value
NC_013037.1\|WP_015810947.1\|1715339_1715912_+\|cupin-domain-containing-protein	gnl\|CDD\|223734	COG0662, {ManC}, Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism].	7.52505e-14
NC_013037.1\|WP_015810946.1\|1714175_1715210_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|378890	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term. AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	6.52711e-32
NC_013037.1\|WP_015810952.1\|1721038_1721932_-\|TIM-barrel-protein	gnl\|CDD\|366542	pfam01261, AP_endonuc_2, Xylose isomerase-like TIM barrel. This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.	8.99683e-07
NC_013037.1\|WP_015810956.1\|1728994_1729810_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|131350	TIGR02297, AraC-type_DNA-binding_domain-containing_protein, 4-hydroxyphenylacetate catabolism regulatory protein HpaA. This putative transcriptional regulator, which contains both the substrate-binding, dimerization domain (pfam02311) and the helix-turn-helix DNA-binding domain (pfam00165) of the AraC famil, is located proximal to genes of the 4-hydroxyphenylacetate catabolism pathway.	1.94303e-26
NC_013037.1\|WP_015810955.1\|1726450_1728895_-\|TonB-dependent-receptor	gnl\|CDD\|379720	pfam14905, OMP_b-brl_3, Outer membrane protein beta-barrel family. This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.	4.88061e-70
NC_013037.1\|WP_015810957.1\|1729942_1730476_-\|YceI-family-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	6.10418e-56
NC_013037.1\|WP_015810944.1\|1712266_1713037_-\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	3.16505e-31
NC_013037.1\|WP_015810958.1\|1730723_1732256_-\|VCBS-repeat-containing-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	7.19683e-12
NC_013037.1\|WP_015810948.1\|1715973_1716396_-\|SRPBCC-family-protein	gnl\|CDD\|176906	cd08897, SRPBCC_CalC_Aha1-like_4, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	7.57873e-79
NC_013037.1\|WP_015810945.1\|1713033_1714134_-\|histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	1.88831e-21
NC_013037.1\|WP_015810951.1\|1720312_1720651_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|163261	TIGR03433, padR_acidobact, transcriptional regulator, Acidobacterial, PadR-family. Members of this protein family are putative transcriptional regulators of the PadR family, as found in species of the Acidobacteria. This family of proteins has expanded greatly in this lineage, and where it regularly is found in the vicinity of a putative transporter protein [Regulatory functions, DNA interactions].	5.77462e-06
NC_013037.1\|WP_041736044.1\|1711300_1712038_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	0.00229414
NC_013037.1\|WP_015810950.1\|1717695_1720065_-\|ABC-transporter-permease	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	1.24285e-71
NC_013037.1\|WP_015810949.1\|1716516_1717554_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274817	TIGR03858, LLM_2I7G, probable oxidoreductase, LLM family. This model describes a highly conserved, somewhat broadly distributed family withing the luciferase-like monooxygenase (LLM) superfamily. Most members are from species incapable of synthesizing coenzyme F420, bound by some members of the LLM superfamily. Members, therefore, are more likely to use FMN as a cofactor.	0
NC_013037.1\|WP_143828685.1\|1739118_1739742_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	2.33446e-27
NC_013037.1\|WP_015810961.1\|1737929_1739030_-\|FecR-family-protein	gnl\|CDD\|377406	pfam04773, FecR, FecR protein. FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm.	3.22621e-13
NC_013037.1\|WP_015810953.1\|1722790_1725187_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	3.15885e-35
NC_013037.1\|WP_015810959.1\|1732344_1734123_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	5.86395e-44
NC_013037.1\|WP_015810960.1\|1734149_1737719_-\|TonB-dependent-receptor	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_013037.1\|WP_143828908.1\|1725254_1726430_+\|DUF4374-domain-containing-protein	gnl\|CDD\|373002	pfam14298, DUF4374, Domain of unknown function (DUF4374). This family of proteins is found in bacteria. Proteins in this family are typically between 406 and 466 amino acids in length.	7.17969e-07

>NC_013037.1|WP_015810952.1|1721038_1721932_-|TIM-barrel-protein
MIQKTLLSMLLLVSQLTLGQKSAGTDNIYARQNLIAWCIVPFDSKERSPVQRAEMLNKLGFTMLAYDWREKHIPEFDAELEALKKHGIKLQAFWLYSGPNPENDKNLPIILDLLKRHNTKTEIWCMIGGIKDMDKMTQQQKVEAVAKPVAYIADKAAEIGCMLGLYNHGGWYGMPENQLEVMDYLKRPNIGIVYNLHHAEEDIERFPQFFPKILPHLMAVNLMGLKKGNPVKVVPIGQGDAEAEMIRIIRDSPYRGPIGIINEDTAPDAEAGLTMNVEGLKKILKEQTDFEALESYK
>NC_013037.1|WP_015810951.1|1720312_1720651_-|helix-turn-helix-transcriptional-regulator
MKRTFLGELEEVVLLTVALLAEEAYAVTVAQELDQKTGRAVGFSTVHTTLQRLEEKGYLSSEMGGATAERGGRRKRFFRVTAFGRKALREAKEARETLWNAMSPQTLQLMGN
>NC_013037.1|WP_015810950.1|1717695_1720065_-|ABC-transporter-permease
MIQNYFKIAFRNLLKSKTFSAINVLGLALGMACSLMILLWIRDERAVDSFHANKDQLYRIYMREHFSGKVQGVIWTPGPLAEELKKSVPEIEMSTPFSWTIQQTFSVGNKIHKQATNWGGADFFKMFSYKLLQGTPEGALRDKSNIVISRNMAEAFFGTPEAAIGKAIRYDNRKEMTVSGVFENIGTNSSLQFDCLMTWDAYVDDNNWATHWSNTDPVTFFKLRKDADPAKVEAKMLHLLDKTNRDGDKPYKTQLAMQPFHEYYLNSNIKDAKMDGGRIEYVRLFSFVAVFILLIACINFMNLATARSSRRAKEVGVRKVVGAMRSMLAGQFMGEALLIATLSAVMAVLLVTLLLPAFNNLTGKQMALPFSEPVFWAVIGGLLVLTGLLAGSYPAFFLSSLNPVRILKGALKFDSSSVWVRQGLVVFQFGLSVILIVGMIIIYRQVGFVQNKNLGFDRENLVYFPIEGDLFSKFDLLKEQLTQVTGIKQVTHMTANPASNGNGTDGITWPGSNPTEQVRFTPVGVGYDFTKTMNLKMADGRDFSKDFPTDSSGVLVNQTAVKVMGLKNPVGREINWGQSKVRIVGVLKDFHFESLHKAIRPLIAYLGARQPQGSVVIRIQAGKTPETLAAIEQICKKFNPNVPFTYAFTDQEYARQYQSEQIVGKLAGYFAFLAIFISCLGLFGLAAFTAEQRTKEIGVRKVLGASVAGIVGLLSKDFLKLVVMAIVLASPVAWYIMKHWLQGFAYQINIEWWMFALAGIIAVLIAVFTISFQSVRAAMVNPVRSLKSE
>NC_013037.1|WP_015810949.1|1716516_1717554_-|LLM-class-flavin-dependent-oxidoreductase
MEIGISMFGDLAFNNATRSFQSPQERLQDMLEEIKLADEVGLDVFGIGEHHRPDFAVSAPEIILAAAASVTKNIKLTSSVTVLSSADPVRIYQNFSTVDLISGGRAEITVGRGSFIESFPLFGYDLNDYNGLFSEKLQLLKEINENDVITWKGKYRATLDRQEVLPRAVNNNLDIWVAVGGTPQSVVRAARLGLPLIIAIIGGMPSQFQPFFELYKTEYLEAGHDPAKMQLATHSHGLIGLDGKALNDTYFPSYAAQMDRVGRSRGWAPYTRSQFEGGQTRNGALFVGEPAAVVDKILYHQEMFGLTRFLMHTDVGAPAHKDLMKSIELLGTHVAPAVKKALAVK
>NC_013037.1|WP_015810948.1|1715973_1716396_-|SRPBCC-family-protein
METTTQPVTVQATINAPVAEVWNKWNAPEHITQWCFASDDWHAPFSENDLRVGGSIKTTMAAKDGSFSFDFGGTYTEVEENRYLAYTLGDGRKVTVSFEQEGDGTKVVETFDPENTHPVEFQQAGWQAILDNFKKYAESK
>NC_013037.1|WP_015810947.1|1715339_1715912_+|cupin-domain-containing-protein
METLTVPELAQTKSLQRVISNQEYTVTFLTTAAESRNRLTEMEVVLLPGGGNELHTHLNFAETFIPVKGTLEVQLGSKKLLLEPGERYTVPVGVPHNFTNPGNKPVHFRVVIEPGHEGFEYSLRMLYGLANAGRADIRNWDDLMSVAVILGISEMRLCGKKAILNPFIPLLYRVARRKGIEEEMIRKYCV
>NC_013037.1|WP_015810946.1|1714175_1715210_-|AraC-family-transcriptional-regulator
MYGTVRVLRNIVYAAVERGGDPGRLCAALGISPADLTDADKRIEGVQPIIDLWTEVVRSTGDQAAGLHIGQANNPSIFGVLGYLMQSCRTLKEAYAQVVKYQQTVSGWISYDFVDGKEFELIFKVHPLWEQVSPETARQGVEMAVAGIFNHIQILTGKQICPVRAELVLQTPVPKATYEQLLRCPVYFGKAQNRVVFERGLGDTRLISADESLYASFAQILREKSAASGQSERFGAQVRAVIARDFGGRIPSLEIIAGHLNLSERSFQRRLHEDGESYRSLAAGLKKELAVSLLRNTDAKVYAISEVLGYAEPSAFHRAFRNWTRTSPVRQKRLTDAPKIVDRS
>NC_013037.1|WP_015810945.1|1713033_1714134_-|histidine-kinase
MQSPITSRLTSRHKWELGLGLAVIYVPIRIYMNVLQIDMPIFWHRLPLWTMELVFSIAFFVLWINVIEWLQYITTRFLGEDFPERHRILNQAIMLVVAIGLAMVFNHWYRYLWHWMEAVFEKKSFDVLPITLNNSPVLKQRANTSITVMALMAEYYLAANKRVYERLQRVVINEERLQKENATAHFNALKNQVSPHFLFNNFSVLTTLVETNQELSVKFINQLSKAYRYILEKSVYDSIKLATEVEFLETYMFLLMIRFENKLNLDIRISCQEREKYSIVPLTLQLLVENAVKHNRMSASNPLLITIGVDGDYLVISNPLQVRELPESSTRLGLQNIVNRYKLLIDKPVMVDKTDGCFTVKVPLLS
>NC_013037.1|WP_015810944.1|1712266_1713037_-|response-regulator-transcription-factor
MNVLIIEDESLSANRLESLVNKYDPKINVMAKLSSVRESIQWLSDPVNVRPDLIFMDLHLEDDLAFKIIEELKLTIPIIFTTAYSEYTLKAFKANSVDYLLKPVDKSELSVAIDKFVALHAKSAVAPMPDFATLMAMYQSGDEGYKERFLATAGQKLFSIRTSEIAYFTIEQKATFLRTYDGQHLAMDYSLDKLAQLLNPKEFFRINRSLIISLNSIRSIYTVSAGRLKLELTPATSQEVFVSGDRMADFKQWLGK
>NC_013037.1|WP_041736044.1|1711300_1712038_-|helix-turn-helix-transcriptional-regulator
MKEFNIDQTLNLVSCEARELEKSSRYGGLFGIAFVTEGEGVLSCDDDSWHYEEQAIFLLSPGHPIHFKSFYRTNLLTIFFDPFRIAGAADPLSGFSGMFRAVRDLFSVPSFLRQNELRSETDRLAVTQLVRLIETELAHVQESSRELVTNSVALLVNLVKRNLADSHRPEPAAQYSEETDRVLNDVRKMLQRNEHLTIQEIAVAMDMSQYNLNKMVIKGTGETLKAIIGRYRSELARARLLDLQA
>NC_013037.1|WP_015810953.1|1722790_1725187_+|TonB-dependent-receptor
MPSSLFTRLFLLISISFIGLQGFAQKVPSVTGYVKTESGEALPGATVSLLKTPHGVTTDANGFFTLPNVKAGSYTIQATLMGYKAMSETVSIQAGKTASLSFQLKENQQNLSEVSVYGKTETQVVKEQAFTVNAIETKQFQNTTADLNQVLNRSAGVRIREQGGLGSNFNFSINGLSGKAVKYFIDGVPMEVMGSAMSLNNIPVNLSERIEVYKGVVPVQLGSDAMGGAVNVITNQKQTNYLDLSHSYGSFNTHRSAVTAQYVHKPTGITVKASGFFNYSDNNYKMKGVEILEGGTRVGNQITDLNGANFVTTNVKRFHDHYRSGMGQVEVGISNKSWADVLYAGFGYSETRQDQQTGFEQAIVYGNVDRKGKSSTATLRYKKSNLLVSGLDVNVFASLSKDKFLTADTLLRQYYWDGSWTVKGATEMGGVKSLSHINRPRSFMRANASYTLSDQHSFNINYTFDRLKNENYNELLVSGDDMPGIMTKQILGLAYQQELLNKRWTNTFFIKYYGLGLERKKWIDNSYQTLNDKFPNYGYGAASRYKILPDLGIKLSLEHTFRLQEVEEVFGDGLNLQPNPDLKPERSDNVNLGSYYGFRTGKHRFFAEAAGFYRNASDFIYPVADQRSKALKNENKSNVRVTGFEAELRYDYADLLSFNVNATYQSAVNMTKFGSTTSNLPEATYKNKIPNQPWFFGNANFGIGKSDVFTKGSRLQFSWFTQYVHWFYLTWEAFGNVNGKSTIPSQLIHNATLSYSFRDGRYNVSAECRNLTDDLAYDNFRLQKPGRAFALKLRYFIQ
>NC_013037.1|WP_143828908.1|1725254_1726430_+|DUF4374-domain-containing-protein
MVALTAFALNGCSDSDDNNGGTPVQEEGKYSAVLCVGAWPNTAYYIADVPSLMGGSISLKGNGAEMTGKVYAQDIIQKDGFYYHANFGSGRFGKYHVEKGVLVIDKEVPFTFLNWSSYVWVDDQTLVILGDAEGEGRYAIVKVADMTLTTGKLDLKAKPAGFTGYNIGFAEYRDGKLFLGYGYAFSDWSQDPLPVNPDFNVAVVSYPSMKTESVITDNRTTTPGGPIVYAPASFKDENGDIYFVSDPVAGYDYKSPSVVYRIKNGATTLDPTYFFDLSAKTDFGMGAAMWYIGNGKAVVRTRIKGESIDAVHSFSIIDVRTGTFIKKLDLPDDEGERMVNAVVVEDGKAYIAVNGADRDYIWEYDPAADKLTRGAEFVDGVDFILRLEKTK
>NC_013037.1|WP_015810955.1|1726450_1728895_-|TonB-dependent-receptor
MRFLLTLAFLFCLLATAGAQRKPSISGKVTDRQTGQGLPYASVALYRSADSALVSGVLADDTGNFRFDKPGAEAYYLETQYMGYNTVRTTVPAGVEELAPIALLADGRVLDAVEVTDNRNAVESRIDRQVYRAGAFLGSQGGTAVDVLKNTPSVTVNSEGDITLRGSTGFLVLVNGKPVQTDPSVVLNQIPANSIENVEIITSPSARFDPDGKSGIINITTKTAEKNSQSLIVNILGGLPSVRTYNNLKNPQRFGADASWGLRAGKWEVNLSGNYLRNDLAGRRVGDVNTTIDGIFTTFPSDGERSFKRYNYTARASVSFTADPSNVISAGFYKGYRFQSRRADLVYNNTKTDLETGQNLGQIIYFNSNIARKTADVTSANLDYLHRFGNKSELTLSGLIEAADLDGLTTNMNLSEPGRNRTLQSTRNPGENPLNAFRLQADYVVPIGKGKLEAGYQYRNQEQKGVFQYLDQNLETGEFVEVPQFSNRTRLLNHIHSVYGQYSGKSGKLEYSGGLRYEYATRQFTAGGTETRDLNLSNFFPSAQLQYAFSKGWRAKAGYTRRVQRTTNNELNPFPEREHSETLESGDPDILPEFIGQAEAGLVKEFEKGSAFLTLYHQRIDNVLNRVNSVYNDSIINRIYTNAGLATSWGIEAGGNANVTRWWQLYAGANVYRYAIEGGLFRNTVVVNTSSVVYSVNATSTFKIAPAWQLQWGISYLSKRVTAQGEDSRFVNPSLSVKKTFLKGKLAATLQWQNMDLGITGANQQRISTWGKDFFTTTNYIQETDIFLLNLSYNLNQLTKKAKLPASEFGEREF
>NC_013037.1|WP_015810956.1|1728994_1729810_-|helix-turn-helix-domain-containing-protein
MQIEIKNKLENNELFRIKRMKEVIKTTRPHGHKEYLEIIFLTQGEGLHQIDHHRFPVSGNSLYLVMPGQIHNWELTAIPKGFVMMVQKDFLLGHPLYDALFQTFPLAFSSGYQLESTASTIQGIFESIEAEHAEQRPNYQAIIQTYLLLLFNLLQRETHIDRTRPEPALLKSFFDLVAAHYQSRHEVAWYANALNVTAKTLNANCRKFLDKTAGAVIGEKLTAESKRRLLYSQANLGEIAYELGFTDPSHFNKFFKRQTGVLPSIYRKGIS
>NC_013037.1|WP_015810957.1|1729942_1730476_-|YceI-family-protein
MSKTTWTVDVAHSEVQFKVKHLVISTVTGFFRTFSGSASTEGDNFENANVNFSIDVNSVDTGQPGRDEHLRNADFFEAEKYPEFRFVSTSLRKDKGDLYKLVGDLTIKGVTKEVELAAEYGGTERDPWGNIKVGFEVSGTIDRKEFGVTFNSLTETGGLALGENIKILANIQLAKQA
>NC_013037.1|WP_015810958.1|1730723_1732256_-|VCBS-repeat-containing-protein
MNWLKWLSGLPLGIFAVAVCMQACGTSGQSGENELTGELAQGRDAAQRHCSTCHLPVDPALLDKDTWKNRVLPVMAQYFGIEVWQRNQYFAGERAAMPIAEWMQIVAYYDSLAPVSLPAARPTVPVCEEWAGFSLKTPATDTSRIATTTLVAIDSARSTIYTSSSETPSLMAWNTAMTKTMKAPLSSPAMHMLFEDEPVLTVVGEMRAYDVTQGELRRFKRSGANDPKPLITGLRRPLHTAAADFNRDGKTDYVVSAFGHNQGGLYEFRQLNDGKFEQIPIREAAGATQSYTGDFDGDGWPDIIALFAHAQEGIWLFTNDRKGGFSEKPLLRFPPVYGSSSFQLTDFNGDGLPDILYTAGDNSDYSRILKPYHGIYIYLNKGDFRLEQSWFFPVNGATKAISVDFDGDGDPDIACVAFFADLLRNPGEKFLYLRNEGGNGLKFQPFSPPIAGQGRWICMDVNDWNGDGRPDIVLGNYSKGFLNQEEVKADWNVYLPFIILQNETHSANAH
>NC_013037.1|WP_015810959.1|1732344_1734123_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKTFRFSKIALVAIFGLISYSCQESFLDKPALGSLSDAQLSTKAGVQSLLIGAYAALDGNGVGAASAWDAAADNWIYGSIAGGDAKKGSDGADQPGINSIMIYSAGPSNGFFNSKWRAAYEGINRANSVLRFIPLVTSGITDAEKTDYTAQARFLRGHYYSELKKMFNMVPWVDENTPDPAAVKNDADIWPKIEEDFRFAMDNLPATQSEVGRANKWAAAAYLAKTYLYEKKFADAKTIFDQVITQGVTSNGLKYDLLPKYQDNFDAAQKNLAESVFAIQMAANDGTNTIDNANTGGMLNFPYNSPFRCCGFYQPSLDLANSFQTDANGLPKVDNYNATTLKNDMGVKSDAAFAPDVTTALDPRIDWTVGRRGIPFLDWGNHPGQSWIRDQSYAGPYSPKKNIYWQATQDKYSDQHSWAPGTAINIQVIRFADVLLMAAEAEAQLNNLAKAQEYVNRVRARAAKPESWVYTYADPSKPMAGFTKTPAANYKVAQYPAGAFAAKGKDGSLAAIYFERKLELAMEGHRFFDLSRWGIAEQTLNSYIAFEGKITPDVRGGKFLKNVNEYFPIPQRQIDLSTKNGVSSLKQNPGYQ
>NC_013037.1|WP_015810960.1|1734149_1737719_-|TonB-dependent-receptor
MKKLYPNYAYWQILMRFSCMQLIIAALLTTVAVAGVTEAQEVLNNRVTIQVQNQDVRKVLSAIEDQVKIKFLYSSSLIKAERKVSVNVRQEQLGAALKTILTPLNLDFEVSGKQIILKRVKMPVERLNPQSYKSATVDRTISGVVTDASGSFLPGVSVVVKGTSRGTGTDADGAYKIDAPDGNVTLTFSFVGFTSKDVDVAAGQNVLDVTLTQDEKLLNEVVVVGYGTASRKDLTGAVSIVKVSELTEQPNANLSNQLQGRASGVTVLTSGQPGQAPQIRIRGINSFGNNTPLFVVDGVPTQDINNLNPNDVASMQVLKDAGSASIYGSRASNGVVIITTKRGQGKVKVSYDMFYGTQTVPKGNVYDILSPQGMADLKFLALKNSGAAINDPQYGSGESPVLPDYIVPTGAKEGSVDLSKYYVNPNYTDKADMDSFYRIVKANKQGTDWFHEVFKNAPIQSHNLSVSGGGEQGNYLFSFNHFNQQGNLMNTFLKRYTIRANSQYNITKNIRVGENIALTLVNNPRTGILEEGGGIGMAYRMQPIIPVYDIQGNYAGSFGSGLGNAKNPVAIRDRARNNRGVVNSLFGNMFAEVDFLKDFNFRTSFGGGQFTYAENTFAYPEWENSENVTTNSYSERVNSGYNWTWTNTVTYEHSFNDKHNVKVLLGTEAYNSTYREVGGSTQNYFSFDPNYTSLSTGSGTPTNFSNRSADALFSYIGRIDYNFKDKYLLSGTLRRDGSSRFTSQYGWFPAVSAGWRLKEEAFMRSATWLTDLKIRGGWGIMGNQFNVDPANAFTTYGQNRSFAFYDIKGTGNSTVLGFQRTRVGNPNAKWEGNINSNIGIDAQLFNGAIDFTIDYYQKNIDDLLFSPELAGTVGQGTAPAVNIGKMKNKGIDMSIYGEKNIGKDLKLNATVTLTTYNNKIVKITDGVSYFDQEGRRFNGSTIVRNAVNHSIGQFFGYNIVGFWNSQAEIDAANAQAAEKSGNPAAIYQNEVKVGRFRYEDVNGDGIITADDRTFLGNPSPKFSYGLNIGATYKNFDFGIFLYGVQGNQIWNNLKWWHDFYTNFQGAKSNTALYDSWTPERTNATAPIQENTGSFSTTNVPNSYYVENGSYLRAKNAQIGYTLPKSLTQALKIDRLRVYVQTANLFTITKYSGPDPEVGQSQVAGSTAFGLDEGVYPNTRQFLVGLNLTF
>NC_013037.1|WP_015810961.1|1737929_1739030_-|FecR-family-protein
MSYYHYGLADFLEDRHFKSWVLTPDRESDDFWNNFLLQHPEKSEAIAGARSLLLGIQSQMEEDFPADDQVASMLEGIQSRRETTGGGQARRLWFRLGASLTAAAVVLVVIGWLRKPNRHDNHVSYSELLSAVEEPLIEQTNTTIAPILLTLPDSSTILLQPKSSVSYRRAFMDNALREVYLSGHAFFTVTKNRQRPFVVYSNELVTKVLGTSFMVKAFEDAKQVEVCVKTGKVSVFPRTDTEVCEGIATPELAGTIITPNQKVLFSRDQIQIRKELVESPEVLVSAVLPAPLQKFQDMPVAQLFSNIEETYGIDIVYDDRLFSQCLLTASFTNESLYEKMDLICKGIEADFQIVDGRMIISGHGCN
>NC_013037.1|WP_143828685.1|1739118_1739742_-|sigma-70-family-RNA-polymerase-sigma-factor
MFGQSKNPDYLASTFTDNDDKVLWQRFRQGDEEAFTALYQRYVRVLYSYGKKLATEDAVIEDLVQDLFIDLWQSRSRLADAESPRFYLFRSLRRRIHKAGNGRFNERWEYIDEGFHPVELSKESEIIESEQFQKQKDELDAWLKSLPGRQYEVLMLRYYQDFSYSQISEMLTINEQSVRNLVQRAVSKLRQLTISAAISGLFIFLLK

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Crispr_ID: NC_013037_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013037_7

1919888-1919993

Orphan

Consensus_repeat	Method
CCTTAGGCTTTATGCTTTTGGTTTGATGTCTATCTGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013037_7

>merge|NC_013037|7|1919888-1919993|CRISPRCasFinder
CCTTAGGCTTTATGCTTTTGGTTTGATGTCTATCTGGGGCTTTAAGCGTTAGGCTTTAAGCTGTAAGCCTTAGGCTTTATGCTTTTGGTTTGATGTCTATCTGGGG

>NC_013037|7|7|1919888-1919993|CRISPRCasFinder
CCTTAGGCTTTATGCTTTTGGTTTGATGTCTATCTGGGG	CTTTAAGCGTTAGGCTTTAAGCTGTAAG
CCTTAGGCTTTATGCTTTTGGTTTGATGTCTATCTGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013037.1\|WP_015811087.1\|1914121_1914361_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015811084.1\|1908060_1908381_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015811086.1\|1912786_1914034_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NC_013037.1\|WP_085938720.1\|1927012_1928350_+\|sugar-porter-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340917
NC_013037.1\|WP_015811091.1\|1918403_1919864_-\|DUF1501-domain-containing-protein	unknown	unknown	gnl\|CDD\|369346
NC_013037.1\|WP_041734816.1\|1916219_1918382_-\|chitobiase/beta-hexosaminidase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379104
NC_013037.1\|WP_015811099.1\|1932507_1934220_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630
NC_013037.1\|WP_015811082.1\|1906095_1907268_-\|FecR-family-protein	unknown	unknown	gnl\|CDD\|226235
NC_013037.1\|WP_015811089.1\|1915857_1916127_-\|SemiSWEET-transporter	unknown	unknown	gnl\|CDD\|226580
NC_013037.1\|WP_015811098.1\|1929319_1932487_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|274948
NC_013037.1\|WP_015811088.1\|1914563_1915838_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|224214
NC_013037.1\|WP_015811097.1\|1928365_1929283_+\|carbohydrate-kinase	unknown	unknown	gnl\|CDD\|238572
NC_013037.1\|WP_041734817.1\|1920065_1922387_-\|PSD1-domain-containing-protein	unknown	unknown	gnl\|CDD\|377876
NC_013037.1\|WP_015811083.1\|1907340_1907919_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274376
NC_013037.1\|WP_041734818.1\|1925605_1926694_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_013037.1\|WP_041736111.1\|1934299_1935802_+\|glycoside-hydrolase-family-32-protein	unknown	unknown	gnl\|CDD\|350134
NC_013037.1\|WP_015811101.1\|1935855_1938570_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380531
NC_013037.1\|WP_015811093.1\|1922559_1923291_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_013037.1\|WP_015811085.1\|1908470_1912790_+\|CusA/CzcA-family-heavy-metal-efflux-RND-transporter	unknown	unknown	gnl\|CDD\|226220
NC_013037.1\|WP_015811094.1\|1923369_1925526_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379889

Protein	Function_ID	Function_description	E-value
NC_013037.1\|WP_015811083.1\|1907340_1907919_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	2.05388e-37
NC_013037.1\|WP_015811101.1\|1935855_1938570_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|380531	cd06308, PBP1_sensor_kinase-like, periplasmic binding domain of two-component sensor kinase signaling systems. Periplasmic binding domain of two-component sensor kinase signaling systems, some of which are fused with a C-terminal histidine kinase A domain (HisK) and/or a signal receiver domain (REC). Members of this group share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily and are predicted to be involved in sensing of environmental stimuli; their substrate specificities, however, are not known in detail.	4.98328e-117
NC_013037.1\|WP_015811086.1\|1912786_1914034_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	7.38833e-34
NC_013037.1\|WP_085938720.1\|1927012_1928350_+\|sugar-porter-family-MFS-transporter	gnl\|CDD\|340917	cd17359, MFS_XylE_like, D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily. This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.75995e-126
NC_013037.1\|WP_015811091.1\|1918403_1919864_-\|DUF1501-domain-containing-protein	gnl\|CDD\|369346	pfam07394, DUF1501, Protein of unknown function (DUF1501). This family contains a number of hypothetical bacterial proteins of unknown function approximately 400 residues long.	7.65079e-177
NC_013037.1\|WP_041734816.1\|1916219_1918382_-\|chitobiase/beta-hexosaminidase-C-terminal-domain-containing-protein	gnl\|CDD\|379104	pfam13287, Fn3_assoc, Fn3 associated.	1.05445e-13
NC_013037.1\|WP_015811099.1\|1932507_1934220_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	4.74685e-40
NC_013037.1\|WP_015811082.1\|1906095_1907268_-\|FecR-family-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	3.72805e-23
NC_013037.1\|WP_015811089.1\|1915857_1916127_-\|SemiSWEET-transporter	gnl\|CDD\|226580	COG4095, COG4095, Uncharacterized conserved protein [Function unknown].	1.58687e-11
NC_013037.1\|WP_015811098.1\|1929319_1932487_+\|TonB-dependent-receptor	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_013037.1\|WP_015811088.1\|1914563_1915838_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|224214	COG1295, Rbn, Ribonuclease BN family enzyme [Replication, recombination, and repair].	1.16906e-49
NC_013037.1\|WP_015811097.1\|1928365_1929283_+\|carbohydrate-kinase	gnl\|CDD\|238572	cd01167, bac_FRK, Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.	1.41469e-60
NC_013037.1\|WP_041734817.1\|1920065_1922387_-\|PSD1-domain-containing-protein	gnl\|CDD\|377876	pfam07587, PSD1, Protein of unknown function (DUF1553). A family of proteins found in Rhodopirellula baltica.	3.67171e-116
NC_013037.1\|WP_041734818.1\|1925605_1926694_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	2.2386e-63
NC_013037.1\|WP_041736111.1\|1934299_1935802_+\|glycoside-hydrolase-family-32-protein	gnl\|CDD\|350134	cd18622, GH32_Inu-like, glycoside hydrolase family 32 protein such as Aspergillus ficuum endo-inulinase (Inu2). This subfamily of glycosyl hydrolase family GH32 includes endo-inulinase (inu2, EC 3.2.1.7), exo-inulinase (Inu1, EC 3.2.1.80), invertase (EC 3.2.1.26), and levan fructotransferase (LftA, EC 4.2.2.16), among others. These enzymes cleave sucrose into fructose and glucose via beta-fructofuranosidase activity, producing invert sugar that is a mixture of dextrorotatory D-glucose and levorotatory D-fructose, thus named invertase (EC 3.2.1.26). These retaining enzymes (i.e. they retain the configuration at anomeric carbon atom of the substrate) catalyze hydrolysis in two steps involving a covalent glycosyl enzyme intermediate: an aspartate located close to the N-terminus acts as the catalytic nucleophile and a glutamate acts as the general acid/base; a conserved aspartate residue in the Arg-Asp-Pro (RDP) motif stabilizes the transition state. These enzymes are predicted to display a 5-fold beta-propeller fold as found for GH43 and CH68. The breakdown of sucrose is widely used as a carbon or energy source by bacteria, fungi, and plants. Invertase is used commercially in the confectionery industry, since fructose has a sweeter taste than sucrose and a lower tendency to crystallize. A common structural feature of all these enzymes is a 5-bladed beta-propeller domain, similar to GH43, that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	6.37387e-165
NC_013037.1\|WP_015811093.1\|1922559_1923291_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	1.27311e-50
NC_013037.1\|WP_015811085.1\|1908470_1912790_+\|CusA/CzcA-family-heavy-metal-efflux-RND-transporter	gnl\|CDD\|226220	COG3696, COG3696, Putative silver efflux pump [Inorganic ion transport and metabolism].	0
NC_013037.1\|WP_015811094.1\|1923369_1925526_-\|hypothetical-protein	gnl\|CDD\|379889	pfam16875, Glyco_hydro_36N, Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.	0.000207445

>NC_013037.1|WP_015811091.1|1918403_1919864_-|DUF1501-domain-containing-protein
MEKPILDYGMNTTRRHFLSKLSLGLGSAALGSLLIPDLFKGGGGEADMEGLMAGLPHFAPKAKRVIYLFQNGAPSQLDLFDYKPMLNKMHGEDLPESIRGTQRLTGMTANQAKFPLAGSIFNFKQYGKSGAWMSELLPHTAGIVDDLCIIKTLNTEAINHDPALTFFQTGAQVGNRPSFGAWLSYGLGSENQNLPGFCVLLSRGKGNGQGVYSKLWTNGFLDSVHQGVQFSSGENPVLYLNDPDGMDRAQRRKMLDKLSELNQGTYNEFGDPEITAKVQQYEMAFRMQTAVPEITDMSKEPESIVKMYGPECLVPGTYAANCLLARKLSEQGVRFVQLYHQGWDSHGGLPSEIRGQCMDVDQASAALVTDLKQRGLLDETLVIWGGEFGRTNYCQGTLTKDNYGRDHHPRAFTVWMAGGGVKPGIVYGETDEFGYNVVKDPVHVHDFHATILNQLGLDHEKLVFKHQGRRYRLTDVAGKLVKGIIA
>NC_013037.1|WP_041734816.1|1916219_1918382_-|chitobiase/beta-hexosaminidase-C-terminal-domain-containing-protein
MRRFLSDWKGLIYNLAFFLNGLLVFLLLFEGRFVVPVWMQAIGRMHPLVLHFPLVVLMLYSLWVLVVDKKESPRWNGELADSLLIIGTLTAAVAAFSGFVLSKEEGYESDTLLWHKWLGVAISVASIAWYGFRNALTPWQWHSKLVAGSFLVLLFVGGHLGGNLTHGEDFLISPLGPSADEPPQVDLEEAMVYEHLVKPVLDQKCLSCHNAEKSKGDLQMQTQALLTKGGKSGVLWDTTKADLGLLISRLHLPLEDKKHMPPRGKVPLTDEEMVLLAAWVKSGSRFGQLVSSLPPQSPVYAYAQNVLGGGRTEAAYDFAAADPDEVLKLNTSYRLVKPLSAESPALFANFYNRANFKIAEVEGLSPLKGQIVAMDLSKMPVRDEDLKVLATFPELRKLILNFTDITGATLGELKKLGKLKELSLSGTAVKMEQVKALKGIPSLKRVYLWSTGLTKAELAQLKKESGIALETGFSGDSVVLALNPPIIVTENQLVAADGAVSLKHQISGTIIRYTVDGTEPDSTTSPVYQKPIPITKNTVLKARAFRTGWYGSTQVGKTFYKAGYRVDSARLGLPSDQGYKAKGALSLFDGKVGDTERVSGTWLGYNQNDFQGFLYFKKPVMASNITVNTLRSLGSYIFPPVRIEVWGGVDEKSLKLLKVITTEIPAKDIPGAENLVYEAAFDPRPLGCIKVEAKPVAKLPAWHAGKGGKGWLFVDEIIVN
>NC_013037.1|WP_015811089.1|1915857_1916127_-|SemiSWEET-transporter
MDFIEIIGLVAGICTSSAVIPQLVTTIKKKKASQVSTAMFIVLLTGNALWVYYGFEKEDVPIVATNLFTIGLNIAMLVLKYKYKKRQTE
>NC_013037.1|WP_015811088.1|1914563_1915838_+|YihY/virulence-factor-BrkB-family-protein
MIRLKDFFTLMKESFSEFSNDNVLKLSAALSYYTIFSLAPMLLLIISIVSFFFGREAFEGELYGQIQGLVGKEAGAQIQQLIKNAAINDKSTTAAIIGGVTLLIGATGVFAEIQDSINYIWAIKSKPRKGWVQYLKNRLLSFSLIITLGFLLVVTLGVNTLVDLLSARLERYFSEVSVVVFSVLNVALVLVIIAALFAVVFKVLPDGHVRWKECLIGAGFTSLLFAIGKFAISFYLGQSDLGATYGASASIVILLTWIYYSSIILYFGAEFTKVFARYDGHEIRPNEHAVRLVRQEMETTTAGIAPQPENEPAGWNAAAVKDKVLDSVYTFIDEKINAVREEIEARISKIVSPAVYYLVLAVLGFCAFMTILLIAGHFLNVWLDSSFLGYIVLLGLLLVLTAACVFGRKTSQGIIRKILFRGSK
>NC_013037.1|WP_015811087.1|1914121_1914361_+|hypothetical-protein
MDLTKNKSHEEGGLATAIEEQTAKLPSDVFLWTSIASMGVSLAFKLSGHKHTALFIGQWAAPFLLLGIYNKIVKTQGHD
>NC_013037.1|WP_015811086.1|1912786_1914034_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MKKLLTITGMLTLLCALAACQNEKNASHEEAPHTEQHSDKNSAEGRENTARLTSAQIKSIGLELGAIEEKELTAALKANGTLKVPNQNRATVNTLYSGVIRTLHVQPGDNVRKGQVIATIANPEFMRSQEEYVAVNERIELAELEFNRQKELSAGNAGALKNFQAASTELKTLQTRRNMLHRQISLMGIDPEQLGDGKLIATLSVKSPIAGVVSDVDVQIGSYVDLTSPIAEIVDNSQLHLDLFVYEKDLPKLRDEQIIHFTLTNAPGKEYDARIFSLGSSFEGESKAVPVHAKVMGNKTGLIDGMNITAAVSLEKAKVPAVPTEAIVSYQGRDYVFIASDAPQHDDEHDHAAADADSVEPGVTFELIPVARGTTDVGYTEITLLKSIPANARVVVKGAFFVLAKMSSPGGEHAH
>NC_013037.1|WP_015811085.1|1908470_1912790_+|CusA/CzcA-family-heavy-metal-efflux-RND-transporter
MLDRIILFSIRNKLVVGIFTLTLIVWGLWSASNLPVDAVPDITNNQVQVITLTPTLAAQETEQLVTYPIEQSLANLPDLVEMRSISRFGLSVITVVFEDDTDIYFARQLITERLKEAEQNIPKGIGTPELAPVSTGLGEIFQYVIHPKKGAENKYSAMELRTMQDWIVARQLYGTRGVAEVNSFGGLLKQYEVAVNPQKLKGMNVTIADIFEALAQNNENTGGAYIDKMPNAYFIRGIGLVSSLDDIRAIVVKNVNGIPVLIRDVAEVRLGHAVRYGSVTYNGEKEVVGGIVMMLKGSNSAAVVARVKEKMETIRKSLPADVEIEAFLDRTDLVNRAISTVRTNLIEGALIVIFVLVLFLGNLRAGLIVASAIPLAMLFALGMMHTFGVSANLMSLGAIDFGLIVDGAVIIVEAVLHHLALRKTTGRLTQDEMDQEVFESASRIRNSAAFGEIIILIVYIPILSLVGIEGKMFRPMAQTVSFAILGALLLSLTYIPMMAALVLPKTVSDKKTLSDKMMAHMQALYAPVLAWAIRFRIAVIAVTMVVFGVAVLLFVRMGGEFIPQLEEGDFAFHCILPQGTSLSQSVETSMQASRIIRSFPEVAMVVGKTGSAEVPTDPMPPEATDLIIVLKPRRDWATSQSYPELARKMEEKLETIPGVFFEANQPIQMRFNELMTGVRQDVAIKVFGENIDTLAAIAPRVARVVESVRGATSPQMERTTGLPQITIEYDRAKIAAYGMNIADINRTVRTAFAGEAAGVVFENERKFDLVVRLDSANRSSIDDVSDLFVAMANGTQIPLSQVATVAFREGPAQISREDGKRRIVVGFNVRGRDVQSVVEEIQGKLAAAKLLPTGYYYIYGGTFENLQKATSRLLIAVPIALLLILVLLYFTFGSFAEALLIFTAIPMSAIGGVFALLLRGMPFSISAGVGFIALSGVAVLNGIVLVSTFNQLKKSGFDQLTPRIVEGTKIRLRPVLMTATVASLGFLPMALSHGAGAEVQKPLATVVIGGLVTATFLTLVVLPLLYLWLEKRHGNAFKTLAIIGLLVAASGQASAQDSPPAVRVKIGQLLEASNANLELEVNRKAIRRDEHQVRAAGIIPKTGVFAENEDLRPTDSRGILKIGISQSIPWPGLYKAQKSRYKHQLEATKASGTLIATNIRRDVRLVYYQLWYLQDKGRLLRSLDSIYITLNQTTALRVRTGDTPGLDSIASTARSRELRALISQNANEMQIQQRLLMQLLNAEGRYLPPDSALEKLPLPDSILHHPHPAVEVQQRNVDIARAGIAVARNENRPDFSGRFFSQRLYGLSDPFTGFSVTAAFPILGSGSYRSRVKAATADADLQQSQLAYSEQVYQTGQAQARQEVGKNSALLAYYESTGLAQASEIIRSATLAYGQGEISFAELSQFLAQAVDIRRNHLESLHAYNQSVIQLYYFINPTQ
>NC_013037.1|WP_015811084.1|1908060_1908381_+|hypothetical-protein
MRFSLIILAFYIGLLSCFPCQDAPVRMAGQISTQAGHDDAGHEDEPGDYCSPFCICACCATVNMPPKISGFTVPSPMPAPSRESFLYKASSAQTNAHLIWQPPRHV
>NC_013037.1|WP_015811083.1|1907340_1907919_-|sigma-70-family-RNA-polymerase-sigma-factor
MSYRSALNEEKELLRQVAAGDERAFSRLFDHYHQWLGMHIYRITRSEQIAEELVHDVFLKIWLNRELLSGIENFSVYLFVISKNAALNALKKIAVERSRFTDLDEAGDIMPEQPDDYRYALIDEAIDRLPPQQRQVYMLSRHQRLSYSEIALRMGLSRETVKKYLQIATASIVTHIGKSVRISPLLVIKIFL
>NC_013037.1|WP_015811082.1|1906095_1907268_-|FecR-family-protein
MNEDKDVRVRALFSRYYSGEATPAEEEELMRYIRSGAHDDIIGDAMKQHWLEPGSESNLFDASQSREMLSSILTTSRHRKPWGAMRRLWVRYAAVAAVLVVVAGLWKQRKSAQEQPAPIAGQTSPQDVLPGGDKALLTLDDGAGIELDKVRSGLVARQGGTEITKKADGLLVYHNRSAGKAGMNKVSTPRGGQYKVQLPDGSKVWLNASSSIRFPSVFPATERPVEITGEAYFEVTKDAARPFTVLFNGSTVQVLGTSFNIMAYPEEGTSRTTLVEGSVSVRNRSGQARLQPGQQAAVTPGGRIQTAFKPVEEAVAWKDGLFYFKNAGVRDVMRQLARWYDVDVTYQGDVPVRRFTGQVSRNVNLSEIVGMLRYAGVNCSLKDHTIVVAQ
>NC_013037.1|WP_041734817.1|1920065_1922387_-|PSD1-domain-containing-protein
MKNRFLFLMAFASAVALLVVSCFQKNGTLQQKSGSGSVSYNFDIRPILSDKCFACHGPDANKREAGLRLDVAESAYAKLKDGNGFAILPGKPEESEVYKRITSVDPSYQMPTPESHLGLLNESEIGLVRQWIEQGAKYEKHWAFTAPVLPALPEVSDEAWPKNEIDRFVLQKMEGAGLAPNEEATQSHLLKRVALDLTGLPPTLAMQEKFAGDQSDKSYEKVVDELLSQKTFGEKMAVYWLDVARYADSYGYQDDEYRTQWPWRDWVINAFNKNMPYDRFLSWQIAGDMLPNANKEQILATAFFRNHKYTEEGGVIPEEYRIEYNIDKTKTFSTGVLGLTVECAQCHDHKYDPISQEDYYRLFAFFNNSKEAGYEGDVSQSKPAKNPIMTISDEEARTLLPFINRPDTSRLSVSVLGDLDTLRPTHILNRGVYDAPGRVVTAAALPAVMKFDTTKIAQNRLGLAQWTTSKSNPLTARVFVNQIWQEFFGRGIVKSTGDFGMQGDLPTNPALLDWLAVDFMNHGWNVKRLVRQIVTSATYRQSARVTEEKLKADPENIYMSRGPRYRLPAELVRDMVLSTSGLLNPKIGGPSVKPYQPKGLWEAATSGRGTLRTYQQDKEDALYRRGMYTFIKLTVPPPSMIIFDASNRDHCEVKRSRTNTPLQALVMLNDPTVLEASRVMAERLVTKSADPKAGIRESFQRILCRQPTDKEMKLLADYYNDEISAFTKDKKTAAKVLNVGEYPHEPKANQAQAAALMRVINALYNMEETITKS
>NC_013037.1|WP_015811093.1|1922559_1923291_-|GntR-family-transcriptional-regulator
MKFSIDHKSPVPLHIQAENLLRTMISEPEHLNGKFLPNEVELAKQLAISRSTLRQALNKLVYEGLLIRKKGIGTKVAEPVISSKAKNWQSFTQEMTARGIVVKNFELHVTWVTPEEKIANFFDIPRDKKVLKLERLRGKVEGPFVYFISYFHPRIGLTGEENFKRPLYDILEKDYLVVATLSKEEVSATAADKFIASKLEVEPGSPILFRKRFVYDQGERPIEFNVGYYRADSFVYTVESVRE
>NC_013037.1|WP_015811094.1|1923369_1925526_-|hypothetical-protein
MKYLFLLLCLTSLAATGQNARSVSNDWLIAPESARATIAYSKDGRDLVLSNGLVRRTFRVKPDLACIEYKNLTNGQQLLRAVKPEASVVLNGVPYPVGGLYGQKENAYLLPQWIDGLQVSDSAFHFVDLKISPLMPYLKWKTAMWAGNKQDASGSEVTLRFRSGLAALAGVDVYVHYAIFDGIPLISKWVTIENRSNADWTVNQVVNEILAVVEEESAVVGKPEEMAKPNGLYIENNYAFNNAMRYSLSDQATHWKTDKHYTSQVNYDYQTPCLLEVHPKVDMGVRLKAGENLESVRTYELLTDSYDRERKGLAIRKMYRTIAPWTTINPIFMHLVSQNDEQVRTAIDQCAATGYEALILSFGSHCNMEDTTAANLRKWKELADYAHGKKVLIGSYSLFSSRKISDEDDVINPKTGKPGGAFFGNAPCMGSKWGLGYLARLKKFMSYTCFDIFENDGPYPGDLCASTSHPGHEGLADSQWRQMALQKELYRWCAANGVYVNAPDWYFLDGTNKIALGYREVNFSLSREQQKILNRQNIYDATWNETPSMVWGFVPLTKYQGGGPEAVLEPLSEHLDAYEQLMMQYYGAGVQACYRGPRLYDTEQTRRTVSNVVGWYKKYRDILNADIIHLRRADGRDWDGIMHVSPQLREKGLVMLYNPTTAPMTRQIKLPVYYTGRHDSVKIRVKEGAPQTFRVNREYEVDYKVEIPAEGYTWLVIE
>NC_013037.1|WP_041734818.1|1925605_1926694_-|Gfo/Idh/MocA-family-oxidoreductase
MQIERREFLSTLSMAGAATLFSGNPLLAATAPKKDKLGIALVGLGYYSTDLLAPALQQTEKCYLAGIVTGTPAKAEAWKTKYNIPEKNIYNYQNFDQIAKNPDIDIVYVVLPPSMHREFVVRAAKAGKHVFCEKPMAPSVADCEAMISACKSNKVKLAIGYRCQHDPNIQAYMKVAKDQKFGKVKMINSAAGYFDARTDHWKQKKSLGGGVMGDMGVYALQGARLATGEEPVSVIAQASTTRPDIYKEVEETMMFMLEFPSGARAACQTSFGINMNYLQVNYEKGWLKMEPQSAYNGNKGSMSDGTIINFPIKSQQAKQMDEDCLAIMNNTDLIAPGEEGLRDIRVVEAIYKSVASGKAVKI
>NC_013037.1|WP_085938720.1|1927012_1928350_+|sugar-porter-family-MFS-transporter
MMTSKKVIFWAFTVALGGFLFGFDTAVISGAEKSIQQLWGLTTVQHGFTVSIALIGTVLGSLTGAIPSERYGRKYTLFAIAILYLLSSIGSALASDWVSFLIFRFLGGIGVGISSVTAPLYISEISPANSRGRLVAMFQFNVVLGILVAYLSNFLLVGMGDNDWRWMLGVQAFPSLLFLVAVLFVPESPRWLIVKRGRVDEARRILAVANGGLDVSGIVADIQNSANAGKVSGSSISIFSSQYKLPVLLALLFAFFNQVSGINAIIYYAPRIFEMAGLGKSSALLSSAGVGLVNFCFTFIAINLIDRFGRRTLMFIGSFGLIATLGLVAQAFYSGNLGGYAVPVYLFIYIAFFALSQGAVIWVFISEIFPNQVRAAGQSMGSFMHWLLAAVIAFTFPYIAETLGGGNTFMIFCGMMVLQLVFVWKLMPETKGTSLEQIEKTLILH
>NC_013037.1|WP_015811097.1|1928365_1929283_+|carbohydrate-kinase
MTPKLTVFGEVLWDVLPDARLAGGATMNVAAHLQRYGMDVAFISRVGHDELGAGLLAFMAQQGLDTQWVQTGETHLTGIAKANVSDSNEVTYKILHPVAWDYIQFDAAAAGKVAISDFLVYGTLAARDRTSRDTLLRYLAHTGAGNAPVRVFDVNLRPPHYTPEHVLELLGFAQIVKMNEHELREVTGWLTTFENEKQAMAFIVDRFRLQMLVLTCGAEGAMVLTSHGDYHRHGGFAVEVADTIGSGDAFLGAFLYQIATGHALPDSLEFACAAGAFVAGKPGALPPFGEQDVRKFVHAQQAAVH
>NC_013037.1|WP_015811098.1|1929319_1932487_+|TonB-dependent-receptor
MQKVLLLVALAVACVVNLPGHAQNRAQVRGVVKSTDGEPLPGVNVLEKGTSNGAVTDVSGAYSITPGAAANATLVFSYIGMQTKEVAVGNQTVIDITLDYDQKSLNEVVVVGYTSSKKEDLTGAIAVVDMAPLKNISSGNPMQALQGRVPGLYIEKTGSPNGTNSRILIRGANTLGNTDPLYIIDGVPTKRPEVFQGLNPNSIESIQVLKDASASSIYGSRASNGVIIITTKNGSNTNGKINIDFNTSISAQSEKYARFKMLNAVDRGRALWRASVNDGVNPEDGYGALYQFDWNKDFSNPILNGVKVQPLVGGDANMPAGDTDWQKEMYKTGIVTNNELTISGGNGTSSLQINLGYYKNTGMLRYTDYDKFSGRINGLTSAFDGKLKIGANMQIASSNETLASTDIGGAATPGLAVTLAPTIPVYAKDGSWGGAIGSGYSDRNNPLHMQEINKWDNAHRLTLFGNVFVEIQPLKNFFLKTSLGADNAAFRFKNIEQSFEEGSFGRPNNSLTIDQNRYLSITWSNTARYNLDLGSHHFKFLAGIEAIKNDSDFEIARKEGFAVQTKDYFVLNAGTGNTNVTGTGSGSRLLSQFARIDYGFSDRYLAAVTIRRDGSSRFGSENAYGIFPAASVGWRIDKEQFFKGVTKISNLKLRAGVGRVGNQEIGDLARFGLYDTRYGARQSQFPNGHNSFFDQFYNIGTAYDLNGANTGNLPSGFVSIQGANPNLKWETTDEANFGLDFGLFEGMIQGSFDYFTRKTSDILITPPVASAVGEGQLRVLNGAAKSNKGFEFSAGYYARPKGDFTYNIMAGVSRFRDRITELPEEVRAAYPGNAVQTILGHSQFDLFGYKTDGLFQNQAEVDAAPAQVGAGPGRIRYVDTNGDKRIDDLDRVFFGTTLPAFEYNVKVEAFYKSFDLAVFGSGIAGRKGFDIYTFYNNFVRGRENVGPGVFDAWSPTNTGSKIPALSLSDANNETRSSDYFNVNTSYFKLRNVQLGYALPSELVQKIKLQRVRMYLMAENLFLIKSKQFSGPDPERTDINAIPIPRTFTFGLNISF
>NC_013037.1|WP_015811099.1|1932507_1934220_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKRKYIFGLMVSGTMLIGTSCNDFLDYQPEGLLSSENIKSASAAESLVTAAYAGIGNDEMIGPMTSMWVYGSVRSDDAYKGGGGVSDVAEVDFYEHYNLTRPDFGMMHPYTWENFYKAISRANAALNSLNGITEAEFPLRTTRMAEMRFLRGHSHFMLKMLFKNIPYIDEKLSSDDILKESNVRYNHDELWNKIGEDFQFAVDNLPQKQAQVGRANKLSAAAYLAKLRLFQAYEQDANHQVTGINKNRLQEVVTLTQQVIASGQYSLQPDFAENFIAETENGPESIFAIQYSINDGTAAGRLSYVTGLNYPHGAPQYGCCGFHQPSQNLANAYRTDANGLPLFETFNDKNVDFANETVDPRVDHTIGIDGHPYKYDATKPFSNAWVRDPGVYGFFHTMKEQQLATSPSYHKEGPFIGSSKNIDIIRYDDVLLMQAEAYIELGQQALALPLINQVRRRAAASTGRLKKTDGSFASKYNIKEYAASGWTQDYARKALRWERRLEFATESPRFFDLVRWGVAAETLNAYLEKEKVRRPFLATAKFTAGRDEYLPIPQREISFTKGLYVQNPGY
>NC_013037.1|WP_041736111.1|1934299_1935802_+|glycoside-hydrolase-family-32-protein
MKKLTILAALLTTNFAHAQETPEKYRPQFHFSPKANWMNDPNGMVFHNGTYHLFYQYYPDAKVWGPMHWGHATSKDMLHWKEQTIALYPDSLGYIFSGSAVVDVNNTSGFGKDGKAPLVAIFTHHNPVIEKQKTGLHEYQSIAYSLDDGKSWTKYSGNPVLPNPGITDFRDPKVCWYEPQKKWVMTLATKDRITFYSSPDLKKWSKESEFGANAGAHGGVWECPDLFPLMHEGKQVWVLIVNINPGGPNKGSAGQYFLGDFDGKTFTANSSKTKWLDWGTDNYAAVTFSNTGNRRLLMGWMSNWQYANQVPTDPWRSANTISRELALTAVDKELYLTSVPARELDAIEEGGYSKQNMAAKAPVNLAPKSGNPSGLFRLDFETASVADFELVLSNKAGNELLIGYDQASNQYYIDRSKSGKTDFEAGFAQKHFAPRLSKNGKIDFTLVADVASVEVFADGGLTVMTDIFFPETPLSELSIKSVKGIQVKDLQYSTLKPSME
>NC_013037.1|WP_015811101.1|1935855_1938570_+|substrate-binding-domain-containing-protein
MRLALIALLLLTLFAGCAGKQEDAYVIGFSQCTGDDEWRRAMLDGMQRELAFHNNTKLIFRDAHANSAVQVKQIEELLRNGIHLLIVSPNESDPLTPVIEKAYKQGVPVVVVDRRTSSPYYTAYVGGDNYQVGKTVGEYAAALLGGNGKMIEITGLPRSSPASDRHRGLVDALATRPSIRRVATLNGQWQKDIAKSELRKVLPRFPDLDLIFAQNEVMAMGAREVCNDIFPDRKIRVIGVDGLPGQFGDIQMVYDGHITATALYPTGGEEAARVAMNILQKQPYQKENLLQTAIIDSSNVRMIKMQTDKMISQQNDIERQQARIDEQLEIYQTQRGLLYVMTGLFIVSIILGSVALYSLIENKKINRELNSKNEEIVVQRNRIQDIAEKAQEATESKFRFFTNISHEFRTPLTLILGPVEELLRQKNESPAVRKNLSLVQKNATRLLWLVNQLMDFRKIESGKIRLQVSGNDMVAFVRELMLPFDQVARKRRIDFRLVTALPALEVWFDRDMMDKVFFNLLSNAFKFTPDWGRIYIHISQAGENVVVSVQDNGSGLSDADMAGAFEMFYQGKNSTKGTGLGLPLSREFVELHQGTIAADGKKGEGAIFTVTLPLGQAHFQPEDLADAATITSAFGRTAVQNEPEPQPAQPLPADLPSVLLIEDNEDLLGFVNALLQDQYQVSTATDGRAGLDQCFETVPDLVVCDVMLPGMDGLEITAALKSDLRTSHIPVILLTAKNTPEQQVEGMQARADMYITKPFSPQFLQESIASLLANRQLLRNTHFGPGVAEAEAGLSRLDKKFVNELRALIIARLDDPALTVESLGKALGLSRVQLFRKTKALLGGGTNELILNLRLEKACTLLRNPDLTMAEIADQTGFTSQSYFSTVFKTHFGVSPKDWRMVRS

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Crispr_ID: NC_013037_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013037_8

2517866-2518002

Orphan

Consensus_repeat	Method
TAAACAGAATGCCCCTCCGGGGCGCAAACGCCTGGCCGCAGAGCGGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013037_8

>merge|NC_013037|8|2517866-2518002|CRISPRCasFinder
TAAACAGAATGCCCCTCCGGGGCGCAAACGCCTGGCCGCAGAGCGGCAGCCCGTTTATAGCACAGCCACTGAATACATAATAGTTGCCGTAAACAGAATGCCCCTCCGGGGCGCAAACGCCTGGCCGCAGAGCGGCA

>NC_013037|8|8|2517866-2518002|CRISPRCasFinder
TAAACAGAATGCCCCTCCGGGGCGCAAACGCCTGGCCGCAGAGCGGCA	GCCCGTTTATAGCACAGCCACTGAATACATAATAGTTGCCG
TAAACAGAATGCCCCTCCGGGGCGCAAACGCCTGGCCGCAGAGCGGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_013037.1\|WP_015811529.1\|2503912_2504827_-\|ThuA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377643
NC_013037.1\|WP_041734917.1\|2507459_2509976_-\|nitrite-reductase-large-subunit	unknown	unknown	gnl\|CDD\|184951
NC_013037.1\|WP_015811541.1\|2521605_2523666_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277318
NC_013037.1\|WP_015811535.1\|2511047_2512400_+\|alginate-export-family-protein	unknown	unknown	gnl\|CDD\|372583
NC_013037.1\|WP_041736295.1\|2502646_2503579_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378974
NC_013037.1\|WP_015811534.1\|2510251_2511010_+\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|381169
NC_013037.1\|WP_015811538.1\|2518080_2519565_+\|rubredoxin	unknown	unknown	gnl\|CDD\|366011
NC_013037.1\|WP_015811543.1\|2526031_2526454_-\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015811544.1\|2526468_2526741_-\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015811532.1\|2507062_2507416_-\|nitrite-reductase-small-subunit-NirD	unknown	unknown	gnl\|CDD\|239605
NC_013037.1\|WP_015811539.1\|2519567_2520047_+\|nitrate-reductase-associated-protein	unknown	unknown	gnl\|CDD\|378232
NC_013037.1\|WP_015811546.1\|2527482_2527695_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236312
NC_013037.1\|WP_015811540.1\|2520061_2521516_-\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NC_013037.1\|WP_015811542.1\|2523861_2525925_-\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341066
NC_013037.1\|WP_015811536.1\|2512436_2513747_+\|NarK-family-nitrate/nitrite-MFS-transporter	unknown	unknown	gnl\|CDD\|177665
NC_013037.1\|WP_187293454.1\|2523704_2523854_-\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|275036
NC_013037.1\|WP_015811537.1\|2514269_2517812_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239155
NC_013037.1\|WP_143828936.1\|2527083_2527464_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015811531.1\|2505598_2507026_-\|type-IV-pili-methyl-accepting-chemotaxis-transducer-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|226951
NC_013037.1\|WP_015811530.1\|2504908_2505571_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107

Protein	Function_ID	Function_description	E-value
NC_013037.1\|WP_015811529.1\|2503912_2504827_-\|ThuA-domain-containing-protein	gnl\|CDD\|377643	pfam06283, ThuA, Trehalose utilisation. This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium.	2.25515e-14
NC_013037.1\|WP_041734917.1\|2507459_2509976_-\|nitrite-reductase-large-subunit	gnl\|CDD\|184951	PRK14989, PRK14989, nitrite reductase subunit NirD; Provisional.	0
NC_013037.1\|WP_015811541.1\|2521605_2523666_-\|metallophosphoesterase	gnl\|CDD\|277318	cd00839, MPP_PAPs, purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain. Purple acid phosphatases (PAPs) belong to a diverse family of binuclear metallohydrolases that have been identified and characterized in plants, animals, and fungi. PAPs contain a binuclear metal center and their characteristic pink or purple color derives from a charge-transfer transition between a tyrosine residue and a chromophoric ferric ion within the binuclear center. PAPs catalyze the hydrolysis of a wide range of activated phosphoric acid mono- and di-esters and anhydrides. PAPs are distinguished from the other phosphatases by their insensitivity to L-(+) tartrate inhibition and are therefore also known as tartrate resistant acid phosphatases (TRAPs). While only a few copies of PAP-like genes are present in mammalian and fungal genomes, multiple copies are present in plant genomes. PAPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.49419e-37
NC_013037.1\|WP_015811535.1\|2511047_2512400_+\|alginate-export-family-protein	gnl\|CDD\|372583	pfam13372, Alginate_exp, Alginate export. This domain forms an 18-stranded beta-barrel pore which is likely to act as an alginate export channel.	5.74683e-10
NC_013037.1\|WP_041736295.1\|2502646_2503579_-\|hypothetical-protein	gnl\|CDD\|378974	pfam12849, PBP_like_2, PBP superfamily domain. This domain belongs to the periplasmic binding protein superfamily.	0.00334945
NC_013037.1\|WP_015811534.1\|2510251_2511010_+\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|381169	cd11642, SUMT, Uroporphyrin-III C-methyltransferase (also known as S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT). SUMT is an enzyme of the cobalamin and siroheme biosynthetic pathway. It catalyzes the first of three steps leading to the formation of siroheme from uroporphyrinogen III; it transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. Precorrin-2 is also a precursor for the biosynthesis of vitamin B12, coenzyme F430, siroheme and heme d1. This family includes proteins in which the SUMT domain is fused to other functional domains, such as to a uroporphyrinogen-III synthase domain to form bifunctional uroporphyrinogen-III methylase/uroporphyrinogen-III synthase, or to a dual function dehydrogenase-chelatase domain, as in the case of the multifunctional S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase/dehydrogenase/ferrochelatase CysG, which catalyzes all three steps that transform uroporphyrinogen III into siroheme.	2.86446e-101
NC_013037.1\|WP_015811538.1\|2518080_2519565_+\|rubredoxin	gnl\|CDD\|366011	pfam00301, Rubredoxin, Rubredoxin.	8.04968e-17
NC_013037.1\|WP_015811532.1\|2507062_2507416_-\|nitrite-reductase-small-subunit-NirD	gnl\|CDD\|239605	cd03529, Rieske_NirD, Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while fungal proteins have a C-terminal Rieske domain in addition to several other domains. The fungal NirD is involved in nutrient acquisition, functioning at the soil/fungus interface to control nutrient exchange between the fungus and the host plant. The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The Rieske [2Fe-2S] cluster is liganded to two histidine and two cysteine residues present in conserved sequences called Rieske motifs. In this family, only a few members contain these residues. Other members may have lost the ability to bind the Rieske [2Fe-2S] cluster.	1.3379e-48
NC_013037.1\|WP_015811539.1\|2519567_2520047_+\|nitrate-reductase-associated-protein	gnl\|CDD\|378232	pfam09655, Nitr_red_assoc, Conserved nitrate reductase-associated protein (Nitr_red_assoc). Proteins in this entry are found in the Cyanobacteria, and are mostly encoded near nitrate reductase and molybdopterin biosynthesis genes. Molybdopterin guanine dinucleotide is a cofactor for nitrate reductase. These proteins are sometimes annotated as nitrate reductase-associated proteins, though their function is unknown.	2.53066e-71
NC_013037.1\|WP_015811540.1\|2520061_2521516_-\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	2.02868e-27
NC_013037.1\|WP_015811542.1\|2523861_2525925_-\|M1-family-metallopeptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	5.02805e-132
NC_013037.1\|WP_015811536.1\|2512436_2513747_+\|NarK-family-nitrate/nitrite-MFS-transporter	gnl\|CDD\|177665	PLN00028, PLN00028, nitrate transmembrane transporter; Provisional.	5.6848e-148
NC_013037.1\|WP_187293454.1\|2523704_2523854_-\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	0.00919665
NC_013037.1\|WP_015811537.1\|2514269_2517812_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NC_013037.1\|WP_015811546.1\|2527482_2527695_-\|hypothetical-protein	gnl\|CDD\|236312	PRK08617, PRK08617, acetolactate synthase AlsS.	0.00407272
NC_013037.1\|WP_015811531.1\|2505598_2507026_-\|type-IV-pili-methyl-accepting-chemotaxis-transducer-N-terminal-domain-containing-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.26584e-38
NC_013037.1\|WP_015811530.1\|2504908_2505571_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.66012e-60

>NC_013037.1|WP_015811537.1|2514269_2517812_+|molybdopterin-dependent-oxidoreductase
MKPSPTSYKSTCCYCGVGCGVVVTKESNGQLSLEGDKEHPSNKGMLCSKGMNLHYTVMDQSDRLLYPQVRLNRSMPLQRATWDEALERTAAVFKTLIKKFGPDSVAFYVSGQCLTEEYYLVNKLIKGFIGSNNIDTNSRLCMSSAVVGYKLSLGEDSVPVCYDDIEAADVMYVTGANPAWCHPIIWRRVEAHKTANPATKIICVDPRVTDTARSADLHLQIRPGTDIVLNNAIGRLLIENDYLDERFIADHTDGFELFRLQVMQRTLAEAADICGVPSADIALAAEWIGRSKGFLSFWTMGLNQSVIGVNKNLSLINLHLITGKIGKPGNGPFSLTGQPNAMGGRETGGLANILPGHREVVNAAHREEMEQFWNTPVRIADKPGLTATEMFEALADDKLKAIWIINTNPLVSMPDMNAVESALKKSRFVVVQDVSNRADTVHFADVVLPAAAWLEKDGSMTNAERRITYLPKVLDAPGEALPDSEILWRFAQKMGFEKAFNYKTNADVYAEYVKVTKGTTIDVTGVSHQLLKEKRSVQWPLSSLDAERSAEVRQPGTKRLFTDHQFYTKNKRAQIHAVPDENTSEPTDNQFPLVLTSGRIRDQWHTMTKTGRVAKLNKHIPQPFLQIHPVDAQERGIQEGSLVTVSSRRGEVRVKAQITTDVRKGLCFLPMHWGKILGSNLVRANNLTSPLVDPKSKEPDFKFSAVQVALYQKPVEKIIIIGAGSAGLGFINAYRQLNANDEIHVFSKEIYPFYNRVMLPDYISGSQTWEQLVKLREDQFAENRITVHKGVSIMHIDRKHKTVIDSNGFEHHYDKLILGMGSKAFMPKGVPNLPGIFNMRSRLDADSLLPFLKQPDPHAVIVGGGILGLELAASFREMDVKVTVIQRSGRFMERQLDPLASELLYQELLDRGIECYFNDEVATFSGSDTVEGIRLKSGRKIDCQVVVLAIGTVPTIDLARNTGLECKRGVVVNDYMQTSDPDVYSAGEIAEWNGQMWGITLAAEQQAEVIANYLAGDISQPYKGSTSMNILKMDGLHLCSIGMTDAPANDPAYEQIVFIDKSKRYYKKCIVHRDKLVGAILIGDKNEFLEFRDLISGGVELSEKRLQLLRASQKAEPMMGKLVCSCNNVGQGNLENAIAGGCGDFQKLCQTTGAGTGCGSCRPEVRSILEKALENSLVAL
>NC_013037.1|WP_015811536.1|2512436_2513747_+|NarK-family-nitrate/nitrite-MFS-transporter
METTNKPLEKLNIFSFKGVQMRTFHLTWMAFFLCFFGWFGLAPLMTVIKADLGLTKPQIGNIIIASVAATVIARIAIGKLCDSWGPRKTYTALLGFGAIPVMTVGLVDSYEGFLLFRLAIGVIGASFVVTQYHTSVMFDKKIVGTANAVAGGWGNLGGGITNMVMPLVFAAFVGAGYLPESAWRIAMVIPGVALLIFAFVYYFFTKDTPAGNFEDLAITNPKAAKTKGTLGIAMRDPRTWALFLAYGACFGIEITFDNVAALYFFDNFNTSLETAGILAGAFGFMNIFARAIGGIVADKVGNKWGMLGKGRLLALLLVLEGIGIALFAQSGSIVGAVITMLCFAMFLKMANGATYAIVPFINQKAIGSVSGIVGAGGNVGAVLAGFLFKSSAISYSEAFMYIGVAIACIAAIVALINFEKEQTVTAETGQLEPVEA
>NC_013037.1|WP_015811535.1|2511047_2512400_+|alginate-export-family-protein
MKRALLLLGMIGTGLLAPMRTMAQFSLSGQLRTRTELLDGQGTMLSKGEKPAFFTSQRTRLNAGYKGYRTQFFVAVQDVRVWGQDASTNNRITNSALNGLMLHEAWGEISLLDTNQTKLGKEFALKIGRQEFVYDDSRVLGNLDWLQQARRHDAALIKYGFNGFTAHLGVAYNQNREFKTGTLYDGVPIGYPAGTNGIGTMYKSLQFLYLGKKLKSGNASFLAVKDDFQKYTLDTAGVKKLADGVRSRVTFGPYLQTKIGKNWTLTANAFYQAGKDKDGASLSAYMYSVRGMYAMNRVFSIGPGFDYTSGTVSGSSKNHTFDPLYGTPHKFWGQMDYFYAANAFGKGGLSDLYINTTIKASEKLSFNTDLHHFSSAATVRVADNQKLSSGFGEELDIIANYNLTKSISFQGGYCAFFSTNSLAQVKGVKNPQKMSNWAYLMINIKPEFLK
>NC_013037.1|WP_015811534.1|2510251_2511010_+|uroporphyrinogen-III-C-methyltransferase
MEAKLTLVGAGPGDSELITLKGIRALQTADVVLYDELANAAFLEFAPAHALKMYVGKKVRKPSFSQDEINGLIVRLARKRGHVVRLKGGDPFVFGRGHEEMEYAQDHGIPCSIVQGITSSTAVPASMGIPVTRRGVSESFWVITGTTQNGELSDDLRLAAQSKATVIVLMGLNKLEEICALYKHFGRGHLPMAVIQNGTRSDEKSVVGQVWEMPRLVRESGIGTPAIMVMGEVVALSPAYALEYLQNMQMAF
>NC_013037.1|WP_041734917.1|2507459_2509976_-|nitrite-reductase-large-subunit
MKAVSNTRIVVVGNGMVGYKFCEKLLSRKKEGQEFSITVFGEEPRAAYDRVHLSEFFAGKSADDLSMAGVDWYAENGIRLFLSDPVVDIDREEKLVRSHHGHIVYYDYLIMAAGSGAFVPSIPGVEKDGVFVYRTIEDLELIQSYAKKARKGAVLGGGLLGLEAAKALLDLGLEEAHVVEFAPRLMPRQIDDAGSRMLQSQLESLGLQIHLSKSTQEIKGDDRIEGMQFADNSFLDVDMLVISAGIRPRDEVAKIAGLETHPRGGIIVNNQLQTSDPFIFAIGECALAHHMIYGLIAPGYEMADVVATMLTGGEKEFLPYDMSTKLKLIGTDVASFGDPFVEEPACRTIRYENKAKGIYKRINVSSDGKTLLGGILVGEAEQYNMLLQTCKNKTILPPDSEDLILGSRGGEEAGAGVMSLPDDALICSCEAVTKGMICHEVGENGHHTVDALKKCCKAGTGCGGCIPMVKDLISGVMKEKGVYVRNVICEHFDYSRQELLDLVKMNGLKTYGAVLDHHGKGDGCEVCKPLVVSLLASLWNENILAKDRAVAQDSNDRYLANIQKGGTYSVVPRIPGGEITPEKLIVIGQVAQKYNLYTKITGGQRIDLFGAHLGDLPDIWEELIDAGFESGHAYGKSLRTVKSCVGSTWCRFGVQDSVSFAIEVEDRYKGLRSPHKLKSAVSGCVRECAEAQSKDFGIIATEKGWNLFVCGNGGSKPQHAQLLATDVDKETCLRLIDRFLMFYIKTADPLTRTATWLNKMEGGMNYLKAVVVDDVLGIAGELERDMQNLIDVYKCEWREVVESPELRKRFTHFVNTPMKDPSITFADMREQKRATEWA
>NC_013037.1|WP_015811532.1|2507062_2507416_-|nitrite-reductase-small-subunit-NirD
METITDTINAVTWHMACYVDDIPEDGGGCAFISGKQIAIYNFSRRGEWYATDNQCPHRQQMALSRGMIGSQGEEPKVACPFHKKTFSLQTGQCLNDDEYRINTFPVMVKENRVYVGL
>NC_013037.1|WP_015811531.1|2505598_2507026_-|type-IV-pili-methyl-accepting-chemotaxis-transducer-N-terminal-domain-containing-protein
MERLDKRVAGNLTRFYVVALFVVALLTVSGLFLVRRTIRNLNHDSRIVNVAGRQRMLSQRLTKLAILKVNGIDHRDSVQFNALLALWKDSHEDLVSRRLPIENGFVTWKSQPLDTMFQELTPVFDRIHNNLLVIDRDSVAVSDKQNALAEVLAAEPQFLSQMDRIVFQFDKESFERLENLERIEWILDLMTILVLVAEGLLIFRPVVNTTRRVVRMLTESEDALQLSNQKLKEANSQLVETQKELLRLEEEKYELQLAEDRIRAGALIEGQEEERKRFALELHDGIGQMLTGLKLHAEKLKAVQFHDEKHQKRFEQLVTLIQDIIQTTRQISFNLMPSVLSDFGLASALKLLCQQAADLSGIRVEFEGETGERIFMSRPMEIGLYRIAQEALNNAVKHANADRIKIKLEQNKNRIVLEIADDGKGFLISNLKSEGQFLTRNGMENIRTRTQLLNGEIEIVSKVHSGTRLVVQVDL
>NC_013037.1|WP_015811530.1|2504908_2505571_-|response-regulator-transcription-factor
MPIRILVVDDHSVVRQGIITLLEDEEDLIIAGEASDGDEVWDMVEKVKPDVILLDLTMPRMPGLEVIRQIVPVFPSAKILVFSMHNNTDYVLSSALNGASGYLEKDTSREEMLRAIRAIAKGDLYFPPYASSVIIKNLLKQLARVPDTRAAQEEVQEKSIWKIITPREQQILKCLTEGMSSKDIAEKFDISSNTVANQRASIMKKANVRNTAELISLAMK
>NC_013037.1|WP_015811529.1|2503912_2504827_-|ThuA-domain-containing-protein
MDRKYTFIFALMLFCTALMAQNPVKNAGNRDQKSKKIVFITGPDSHGKGEHEHNGGSTLLAKALNDSLPGATAVIVRNGWPEDESVLDDADAVIFYLDGGGTDHLELVHEAKMEQLVARGIGIVNLHFSLEVDARAGSKQFLKWIGGYFETNWSVNPVWEASFASFPDHPVARGLKPFSIVDEWYYHMRFPADMKGVTPILKALPPESTLKQPDGTHSNNPAVREAVITRKEMQTLAWAFERPDGGRGFGFTGGHMHKNWQNDNFRKLVLNAIAWSAKMDVPAEGVPSATPTDKELDALTKRVN
>NC_013037.1|WP_041736295.1|2502646_2503579_-|hypothetical-protein
MKNFKSIFMAAGLALAAFSNASAQESGENKVVVTGVRFAYPLVEKWIKEYTAANPKAQIVIETRTITDPAKYDLLIEAYYQDKEVKDTREYISIGKYALLPVANAKSAFAKEYADKGLNEKTYKQIFFHDIYAQKDKSLTTEYTIYTRLQKAGAPLTFARYFGYEQQNIKGKSIAGADEHLIKALLKDETGITYTTPGLAYDLQSRKPLEGLTIIPVDLDGNGRVSKEEKALENLDQVIATLEAEKVKNVPVENIHFSIAKNNSNPEAKKFLLWVAANADKDLHQFGYLKADAKRLADEKEKLERFQAVK
>NC_013037.1|WP_015811538.1|2518080_2519565_+|rubredoxin
MRDYYHIKINLPGGIASPGYLKDILSAAWNANVRNVRFGSRQQLLMTVHYEDMRFLESDFKKLGIFYEVNTDRRPNIVSSYCGEEVFRTGQWLNASEYHSVLDSFDFEASWKPGLKINISDSNQSFTPFFTGNLNFISSPEPHFWYLYVRLKQTNTVFKWDGLVYTNEIGRLSRVMDECMLDEQINEENALKAAVNERIRYVSQPAQQDLELPSFSLPYYEGFNRYESRTWLGLYRRDEEFSIDFLLDVCTLCLNTRVGEICATPWKSLVIKGIEDQYRESWSNILGKHNINVRHAANELAWQTEDHNGDGAELKNELIRHFSKNDTRTFGLCFGIQTRPKSEVFGSVLIRKRPLLRIGQLPVFSVYDLYYTENFNPNSRTQVLFEKGLFKIHLPAQLERLCRRFNNQRSRDTLKTMLSEPDEAKTAVRPVKTAHQCPDCMTIYDPEFGDILGDIPPGTAFEDLPAAYCCPTCDAAKADFVPVELTRFTHLEPA
>NC_013037.1|WP_015811539.1|2519567_2520047_+|nitrate-reductase-associated-protein
MNTITAIETRFFAFESDFVDSLRCIPMIVRYKLDTCRVKLQLADWARLNYHEKDELAELPCHSQEEIDAYADFVHALVWKYTSTVPSLLKTLDAAWVHTQVPAEVREKAQEWNCPVISAHQWMQLDVLERFALVKLSRSGHEGRNFPRALAEFGLAAAC
>NC_013037.1|WP_015811540.1|2520061_2521516_-|TlpA-family-protein-disulfide-reductase
MRYPLYIYLVCFGIVFLFTGCEYKKNNSVKVTIDYPKLAGDTVSIGRVNMVDVSTIELGKVLLDSAGKGVVEVEVEAPVFAHINGKELAAGILIYPGDEIEIAPSAAGARLAVQFRGDGAAVNQALNETQQIRSEFEKWNGTYYFQLNSEDFLAAKDSLQKSYDHLFSKLKSDTQVSAERLALLTHQTGMHVVSYQYNFAIGKDTSEIPAQVRRVVEHLPIDTVALQSGMFDYSLVASQFFQHRINNAVYEENDQMDSDSLESIFPMMVEKKIKANEYPKPIEDFIRVKSADVQIRLNGLSPNMITLANTIEKEVASEELKKVIREDVSRWEKLGPGKPAPDFTGTTPDGKKLALSDLRGKIVYVDIWATWCGPCVGEFPESKKVHSEFKEDDRVAFLYVSIDRDTLAWKKMVAAGRVPAGHHMLTSADAPESVWNLYHVWGIPRYLLIDAQGRMVATHAVRPSSGNVQGELRKLLSKSRIAQK
>NC_013037.1|WP_015811541.1|2521605_2523666_-|metallophosphoesterase
MHTVLLSACLLAHIIPGLLRGPYLQSATSTSIIIRWRTNEPTDSRVLFGESPATLFQSVDSTSSVTEHEVKLTGLQPKKRYYYSIGSAQGVLQGDAGNFFETAPLPAQTGKYTIGVMGDCGNNSVNQINTRDKLLDFLGNEYMDAWLLLGDNAYMTGTEAEYQSGFFNIYKDRLLKQTPLYPTPGNHDYANNASRQVDHAVPYYNIFTVPSAGEAGGVPSGTESFYSFDYGNTHFLSLDSYGMESGNTRLYDTLGTQVQWVKADLAANTNKDWVIAYWHHPPYTKGSHDSDIELELINMRKNFIRILERNGVDLILCGHSHDYERSKLMHGHYGLENSFNPAIYNLSQSSGRYDGSSESCPYIKKSSDNEGTVYVVAGSAGQLGATKAGYPHNALPFANASYGGAVLLQVEGNRLDAKWIASDGIVRDQFTIVKDVNKKTSVEIEKGESITIASSYIGSYLWSTGDTSREVTVSPAVTTEYVVKDEYSCLSDTTEVIVTNPLPVKLSHFSGSFHDGRVTLEWETTEEINAGYFLVERSQDGRTFEPIGKVDALGDSRKVNAYHYDDENVNDNFYNSNIYYRLKEVDRDGKTQYSRIVSIKLDSYANDKIRIKPNPSSGEEIWVEIGKGIGKCKLILSNVNGQTLREMSSNAETIAQSYPLGKLNAGTYIIKAVFGSEIISRKFVVR
>NC_013037.1|WP_187293454.1|2523704_2523854_-|T9SS-type-A-sorting-domain-containing-protein
MLYDVKGNRILLKTKSSGGTKTFDVRHLNSGIYSIVSQKGEVLFKFLKE
>NC_013037.1|WP_015811542.1|2523861_2525925_-|M1-family-metallopeptidase
MRALFLLILFLFTKPVLAQESLPDISTEEIAAIESKRAGILAGERSMRVKASNNFDVKYYRCEWEVDPASYYIKGKVTPHFTMNAAGNVITLDLASGLTVASVKQRGSDVAFSHVGDALMITLQNPLSQGVKDSLTIAYEGIPPGNHGAFVTSVHGPASTPVLWTLSEPFGSRDWWPCKNGLDDKADSVDIFLTHPAVYKAASNGLLQAETALSINLTRTHWKHRYPIASYLVAFAVTNYSVLDNSVVIGGTSVPFKTYCYPESQFNFQNGAQNALNAMVQFSNLFGDYPFKNEKYAHVQFGWGGGMEHQTCSFMGSMAETLIAHELGHQWFGDKITCGSWEDIWLNEGFATHLASIYNEAKYPLNTKFTRTSEVNTITSQPGGSVWVNDVNDAGRIFNNRLSYLKGSHLLYMLRWILSDATFFSAVKNYINDPSLAYGYATTAHLKSHLEAASGKDLTYFFDQWFTGQGYPSYQVEWYPIGNAVQVRLEQTRSHASVNFFQLPVPLLFRNSQTNQQKLVVLDHTVSGQLFSENLGFEATEVVFDPDVWLITRNNTITKSSGQLPVVFSSFEVQCRGNGARLTWQTIEEVGADYFEIQGSDDARQWQVLGTVRAFGNSKATNDYSFNVEASSSRNFYRVKEYDLDGKTQETRILVAKCGKEKSDWAVHPNPAIDFFYINPFQQKSDS
>NC_013037.1|WP_015811543.1|2526031_2526454_-|hypothetical-protein
MGGRKFFLTDTYSDMELITSEAVRLAVRMQPQPGGNGLSHSGQHFSASEGNTASGLLISNQGGNFQWENNASGQAWTLKSTYFLIDRNRVAHRASRRAFMTVFARGKRDVVRYLREHRVDFANASDLQQLLHFCNNLPSR
>NC_013037.1|WP_015811544.1|2526468_2526741_-|hypothetical-protein
MKLLLLASLLLPTVTPLDVAPHVGDLPKESASCNPQIRQPTGYLFPQFVQGTVYFRNGTKRPAKLNYHFRHGGVQFVDAQADTLLSRAST
>NC_013037.1|WP_143828936.1|2527083_2527464_+|hypothetical-protein
MEMGTIKAVHIYVHRRLYVTAELELNLKGVKYTFGGHEVFTSGINGGESADPPHLGRFLFRCMQVCRVSNWDELKSSKVLVEINQGRVVAIGDASGSNWFNPTREFEEMDRERSQTEPAFREGTKN
>NC_013037.1|WP_015811546.1|2527482_2527695_-|hypothetical-protein
MPSITNREDDGRLEPGVVLVVSGAESENDAVLAIENYLRVNQKEHLELALPEKCEDGSFQVRLEEPAANG

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Crispr_ID: NC_013037_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013037_9

6620700-6620803

Orphan

Consensus_repeat	Method
TGCTCTATCAAATTTTGACAAAGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013037_9

>merge|NC_013037|9|6620700-6620803|CRISPRCasFinder
TGCTCTATCAAATTTTGACAAAGCACTTGACAAAGCACTTGACAAAGCACTGATAACGCACTTGACAAAGCAAGTGTCTGCTCTATCAAATTTTGACAACGCAC

>NC_013037|9|9|6620700-6620803|CRISPRCasFinder
TGCTCTATCAAATTTTGACAAAGCAC	TTGACAAAGCACTTGACAAAGCACTGATAACGCACTTGACAAAGCAAGTGTC
TGCTCTATCAAATTTTGACAACGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013037.1\|WP_015814913.1\|6613834_6614554_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NC_013037.1\|WP_015814911.1\|6612409_6612832_-\|STAS-domain-containing-protein	unknown	unknown	unknown
NC_013037.1\|WP_015814916.1\|6616390_6617467_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226612
NC_013037.1\|WP_015814931.1\|6626982_6627825_+\|MYG1-family-protein	unknown	unknown	gnl\|CDD\|226736
NC_013037.1\|WP_015814917.1\|6617638_6618040_-\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015814923.1\|6621320_6622244_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015814927.1\|6624478_6625339_+\|DNA-adenine-methylase	unknown	unknown	gnl\|CDD\|223415
NC_013037.1\|WP_015814925.1\|6622877_6623078_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015814930.1\|6626187_6626904_-\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_050774731.1\|6625540_6625966_+\|ASCH-domain-containing-protein	unknown	unknown	gnl\|CDD\|119346
NC_013037.1\|WP_015814920.1\|6619566_6619755_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_015814918.1\|6618052_6618862_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119397
NC_013037.1\|WP_083769178.1\|6619738_6620041_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NC_013037.1\|WP_015814924.1\|6622437_6622866_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|239942
NC_013037.1\|WP_015814914.1\|6614592_6615555_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238744
NC_013037.1\|WP_015814912.1\|6612882_6613818_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|183621
NC_013037.1\|WP_015814919.1\|6619327_6619570_+\|hypothetical-protein	unknown	unknown	unknown
NC_013037.1\|WP_083769180.1\|6628460_6628769_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|366837
NC_013037.1\|WP_015814928.1\|6625358_6625544_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|259851
NC_013037.1\|WP_015814926.1\|6623110_6624259_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238082

Protein	Function_ID	Function_description	E-value
NC_013037.1\|WP_015814913.1\|6613834_6614554_-\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	6.24648e-06
NC_013037.1\|WP_015814916.1\|6616390_6617467_-\|hypothetical-protein	gnl\|CDD\|226612	COG4127, COG4127, Uncharacterized conserved protein [Function unknown].	0.00487127
NC_013037.1\|WP_015814931.1\|6626982_6627825_+\|MYG1-family-protein	gnl\|CDD\|226736	COG4286, COG4286, Uncharacterized conserved protein related to MYG1 family [Function unknown].	1.15333e-25
NC_013037.1\|WP_050774731.1\|6625540_6625966_+\|ASCH-domain-containing-protein	gnl\|CDD\|119346	cd06554, ASCH_ASC-1_like, ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation. The domain has been named after the ASC-1 protein, the activating signal cointegrator 1 or thyroid hormone receptor interactor protein 4 (TRIP4). ASC-1 is conserved in many eukaryotes and has been suggested to participate in a protein complex that interacts with RNA. It has been shown that ASC-1 mediates the interaction between various transciption factors and the basal transcriptional machinery.	2.32866e-19
NC_013037.1\|WP_015814927.1\|6624478_6625339_+\|DNA-adenine-methylase	gnl\|CDD\|223415	COG0338, Dam, Site-specific DNA methylase [DNA replication, recombination, and repair].	6.74885e-41
NC_013037.1\|WP_015814918.1\|6618052_6618862_-\|hypothetical-protein	gnl\|CDD\|119397	cd06529, S24_LexA-like, Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response.	0.000439565
NC_013037.1\|WP_083769178.1\|6619738_6620041_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	1.55833e-08
NC_013037.1\|WP_015814924.1\|6622437_6622866_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|239942	cd04496, SSB_OBF, SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date oligomerize to bring together four OB folds in their active state. The majority (e.g. Escherichia coli SSB) have a single OB fold per monomer, which oligomerize to form a homotetramer. However, Deinococcus and Thermus SSB proteins have two OB folds per monomer, which oligomerize to form a homodimer. Mycobacterium tuberculosis SSB varies in quaternary structure from E. coli SSB. It forms a dimer of dimers having a unique dimer interface, which lends the protein greater stability. Included in this group are OB folds similar to Escherichia coli PriB. E.coli PriB is homodimeric with each monomer having a single OB fold. It does not appear to form higher order oligomers. PriB is an essential protein for the replication restart at forks that have stalled at sites of DNA damage. It also plays a role in the assembly of primosome during replication initiation at the bacteriophage phiX174 origin. PriB physically interacts with SSB and binds ssDNA with high affinity.	3.99496e-20
NC_013037.1\|WP_015814914.1\|6614592_6615555_-\|VWA-domain-containing-protein	gnl\|CDD\|238744	cd01467, vWA_BatA_type, VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.	5.65252e-25
NC_013037.1\|WP_015814912.1\|6612882_6613818_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|183621	PRK12607, PRK12607, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	0
NC_013037.1\|WP_083769180.1\|6628460_6628769_+\|HNH-endonuclease	gnl\|CDD\|366837	pfam01844, HNH, HNH endonuclease. His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.	9.83724e-09
NC_013037.1\|WP_015814928.1\|6625358_6625544_+\|hypothetical-protein	gnl\|CDD\|259851	cd00569, HTH_Hin_like, Helix-turn-helix domain of Hin and related proteins. This domain model summarizes a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed helical bundle. The principal DNA-protein interface is formed by the third helix, the recognition helix, inserting itself into the major groove of the DNA. A diverse array of HTH domains participate in a variety of functions that depend on their DNA-binding properties. HTH_Hin represents one of the simplest versions of the HTH domains; the characterization of homologous relationships between various sequence-diverse HTH domain families remains difficult. The Hin recombinase induces the site-specific inversion of a chromosomal DNA segment containing a promoter, which controls the alternate expression of two genes by reversibly switching orientation. The Hin recombinase consists of a single polypeptide chain containing a C-terminal DNA-binding domain (HTH_Hin) and a catalytic domain.	1.7121e-05
NC_013037.1\|WP_015814926.1\|6623110_6624259_+\|hypothetical-protein	gnl\|CDD\|238082	cd00140, beta_clamp, Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric ring formed by PCNA (found in eukaryotes and archaea) and the processivity factor (found in bacteriophages T4 and RB69). This structural correspondence further substantiates the mechanistic connection between eukaryotic and prokaryotic DNA replication that has been suggested on biochemical grounds. .	5.05218e-51

>NC_013037.1|WP_083769178.1|6619738_6620041_+|helix-turn-helix-domain-containing-protein
MTAMDNPFEYLARELAEVKKLLHDQSEQLRELQGVEKDRRMFLGEAAEYLGIAKPTLYAYLSKKKITHSKTGNKVIFWKSDLDAFIKGGTVEPRRKLALR
>NC_013037.1|WP_015814920.1|6619566_6619755_+|hypothetical-protein
MKILINLFGGLVVSMAVIILASLEALVAFLSLRVNWSLVLVLGLSAVFISTFVKRKRYDRHG
>NC_013037.1|WP_015814919.1|6619327_6619570_+|hypothetical-protein
MEGTIKERLLKRFTDAREKLGPKWRERLVEAEPKFDSIEGERTMNSVSGAVSERRRCGVDRIEAVVVAMEKALTEQTVEA
>NC_013037.1|WP_015814918.1|6618052_6618862_-|hypothetical-protein
MAGTIQRIKEFIDSQGFTVASFEKLVGFSNGSLASQIKNNKSIGVDKLENIVSKFPEISPAWLLKGEGPMLRSAEFEISKNPKPAPNAIPINIPQPGEEEDLELIKREDSTEFRHLGDDQYLVICPLVEQYAYAGYVAGWSDAVYVDDLPRHTVVMKNLTLGVYRSFEVRGDSMDNGLRKSFADGDILTGRKLYQKHWRSKLHIHKYKYFILVTIDGIQIKEIIDHKVDEGIIVCHSLNPDKEMYPDFELSLADVREIYYVKARTEPLD
>NC_013037.1|WP_015814917.1|6617638_6618040_-|hypothetical-protein
MSGKEKLLVGILIFIVLFAALKLSDEPAKPLTPEQITEQKRQDSLQAEYNRQKENLRTIRYLVKSHIKKNLKDPDSFDEIQHEEFEVTNKTKKLYYQASIKYRAKNSFGGYNVEKWCFNFDKNLQNTKVFECE
>NC_013037.1|WP_015814916.1|6616390_6617467_-|hypothetical-protein
MTSTLLEDLELIESNLSIIPDTKKYWLVRTQSGNLYNPFKNNGLISIEHGYFAKRSLEEIWSNTPSEEKFLRRAVKELLTRRFDLDSVGLIAGQISRFAFEVKKDDIVIIPSSGTDEVTIGVVKSDLIETPELAQRVFQEATDVPSGINSNYRLSRKVRWMREIRKRHIDPYMYKMLQAHQAISNVTAYGDIIERSVKSFFARDNEASVVLSVEQEGEISAKDLFALGHYLMQSVDGIITAYDLPFTTDHVDIKINLNSPGRIQLTSRNIKLALLVAVVVASFGIVLFGGGLKIKFQDFDLDLSTDGAVQKIIDYKNNAQDREIKDRLVRSLDSLKVMPPEDALQLLKQFSTNKDNPK
>NC_013037.1|WP_015814914.1|6614592_6615555_-|VWA-domain-containing-protein
MNWNYPFGSTEYFFIFFFIFAYTAYIIRTVRIARQLQTTARTLIIKLFLRSITFSLLIISLLGPSFGEAERDIQAKGKDIFMVVDLSKSMDAADVTPSRLEKVKFELNRFIENERANRIGIIIFSNDAYIHVPLTYDAAALELFIQSLQTDLLPTNGTNVCGAIEMAYNKLMNSADPTSRAKMMVLFTDGENSSSCTNALFNNLRRFGIGVYSVAVGTKVGISIQENGKPLKDKNDKLVISKLDENFLRGIANSSRGSYYELNNSKNDIQKLISDINQAEGALVDSRTITVVSNKYYYFLGAALVLILLDVLITIGTFRL
>NC_013037.1|WP_015814913.1|6613834_6614554_-|hypothetical-protein
MTSLILYVLLWLWDNRTFDSITKANQRKLDAEQAYQKKDFTQSAELYRQITYGSLFSDPAARLNLAHSLYKTRDYKQALKHYRLLSDIDDHSIASIANAQIALILVNRKDTASALTSLRTALRLEPGNALARTNYIILKKSFSGVDEQSDVTTRKRRSNQQQPNQVQPAPPPAPPQEIREVSDDVKKEELLKSLKAMNMSEEQARAILDAMKSNESQYIYQLRRKQYNARPGQKSEIEW
>NC_013037.1|WP_015814912.1|6612882_6613818_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MNSIPATNFQFPGQTGFYKGKVRDVYSFEKRLVMIATDRISAFDVILPRAIPYKGQVLNQIAAHFLNATSDIVPNWLEEVPDPNVSIGLKCQAYPVEMVVRGYLAGHAWREYKAGKREVCGVALPEGLKENDKLPQPIITPTTKAHEGHDEDISREQILAQGLVSEDEYEHLERYTLALFARGTEMAADQGLILVDTKYEFGQLDGTIYLIDEIHTPDSSRYFYKDTYEENQRAGVAQKQLSKEFVREWLIENGFQGKDGQTVPEMTDEKVTSISERYIELFEKVTGMQFQKNNLDHPLERIEKAILRAVA
>NC_013037.1|WP_015814911.1|6612409_6612832_-|STAS-domain-containing-protein
MDFKLEKKEQYVYIETDAPAFAGDVPAAFEETARSLFREGYHSLIVNMQTVKSLDATGITTLKKVNYLCANDLGMLAIVTRDDDFIDLLEDLRIPDLTVLPTKEEAIDAVFMHSLENEFGAGDDDYDDEDYEGVSESKEP
>NC_013037.1|WP_015814923.1|6621320_6622244_+|hypothetical-protein
MSNLSLYNQPDRSQTGVAQQLSRTENQLISASVPGDHNLRIADMTGKQIGDIITAIVLKAAVRLGSKARDAEEQKIINAELNRDLITKLPGFTEREIMVALENGLDGMYLRKPDDPIIFTPSNFVQWCRSFVEQTKKPVMKKAAQLLHQQKDEEFTAPESEKLRMSHEFFLSILKRVLDGESYEDYGNVVYNFLDKIEFLGCGSEQKWRAMDQAKLRMIAEAREIKDANSQRSAVKNAMELIAKAENEKPDELIVSMAKRIIINEKMNAFREMPDDEQGMLLESIAERVDYMCIELKDPEQYKPDEE
>NC_013037.1|WP_015814924.1|6622437_6622866_+|single-stranded-DNA-binding-protein
MKQIQIIGNLGRDAKIFSSNGSEFISFSVAVNDDYTNANGERIERTDWFNVTTTRLSLLQYLTKGTKVFVQGPIRSKPFTKEDGSTVVDINVSATWVQLLGTPGTAEAAPAQQSRVNPDPEGINQDLMAEMAAQNESDDLPF
>NC_013037.1|WP_015814925.1|6622877_6623078_+|hypothetical-protein
MTATIKIECESYDDLQAHLSEIKNELKRKKKVIVAEEEQEIRIEDSNCYGSHEVELTVFDLFTLPR
>NC_013037.1|WP_015814926.1|6623110_6624259_+|hypothetical-protein
MVSEQIEIGGSVETADLKRALHLFAKVVREAPLIPILDNILFSFELDELHLTGSNLITTVFTSIQADGSSTVGKFLLPYRQIKALVSLSPAGKIAFRAVESEDVGTEVMVTTEYGEFKFSSLEKIGDYPALSWSPISHFNIGMDELREGMKLTRKTVSTDELRPPLTGIYFDTAEGCIKFISTDGHKLTKYETSEPAVESILPFILPANFADFVISNTALKQNAVSFGCLPGAKVVANFGSCVVLVRCIDEFFPNYKAAIPEAFEHAVQLDLAQIKTRIQLGLLFSNRATTQMAFVFSNGRLSLESEDFDYGMKSKQSLEMEQPVPELKIGFNVRFMSTILAPFSGKVTLLMSAPNKPAVFIPQAKFGKSVQLLLMPVMLMS
>NC_013037.1|WP_015814927.1|6624478_6625339_+|DNA-adenine-methylase
MIAEIKRPVLRYHGGKFLLAPWIISHFPKHRIYVEPFGGGGSVLMQKPRSYAEVYNDKWDTVVNVFQVLRDPDLSANLKRMLELTPFSRTEFLKTGEIDLREISDPVEKARLTIFRSFAGFGSASTNSKYATGFRANSHRSGTTPAQDWVNYPANIETFVERLRGVCIENRDFKVITEQHDSPETLHFWDPPYVHETRNMQRGNAAYECEMTDEQHIEMIEFGNSLKGMVTICGYDCDLYQAHLSGWMKVSRKAFADGAAERVECLWLNPAAQVRQKQLTIFSSKL
>NC_013037.1|WP_015814928.1|6625358_6625544_+|hypothetical-protein
MSKAEKHGARSNRAVLTATDIPIIRQQIGAGRSYQQIATRFGVGRQAIYTIAKGINWKHVL
>NC_013037.1|WP_050774731.1|6625540_6625966_+|ASCH-domain-containing-protein
MKALTIQQPWAGLLVLGVKTCETRSWNTKFRGRIAIHSSAKMSAEGKELFEQLCELKPDVFYEGSEAWELCTTTGHVLGTVTIEQVFSTNQRKPSNEGELMLGDYSPNRYWFWCIRPEVYQTPIPASGQLMIWEWDENQER
>NC_013037.1|WP_015814930.1|6626187_6626904_-|hypothetical-protein
MTENIKRVTNPLTIIAIFAALAEVNSTVAIGLVGKEHQGLFLWFVILFPTLLIVLFFATLNANPKVIYAPSDFKNEEHFLKTVSGEIYSFGKKAQVSFNKETIKSIDTDTKEIQTYPLSNDKVSGFRQQEIFKKIAKKLEVLFEANLISGVGVSVKNVNYYLLTIKFSQKRFTTLTEPQLNFSFIIRFPPPGDVDKLVTLFDFDIELSSKDIDTIGDAFVRHLNKIGEKLAKDDAAEI
>NC_013037.1|WP_015814931.1|6626982_6627825_+|MYG1-family-protein
MKLKFNRLITHDTTFHADDVIAVALLIVAGYDGFSLSRTRDKATVEEALRSSETLILDTGMAYDPVMLNFDHHQDKNLLSAAGLIYNEIKDELLAEEAQPYFEKWISSIDAIDTNRDHIYHLWDQLPSGFRHTSSILGGFNRDPSNAEEQDRQFGQAVEMAKSIILNEIYSATKKAESERQYASRVVLENNVAVFDDYSTVWKEKRDHMFVVMPHANGWQIQTIDTALDLIPESISLAPGFSFRHMSGFMATLDTKENAVSFAATLPHHPSLHKNEVVYQ
>NC_013037.1|WP_083769180.1|6628460_6628769_+|HNH-endonuclease
MIELSGLIPRTAAEVRKIRDCREWRDRVRPQQLLDFPYCQTCDKKGRLVEAVQVDHITPLEVGGLPFDQKNLQSLCKRCHTIKSAEEARRRNKQPSIINKQQ

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_013037_7	7.1\|1919927\|28\|NC_013037\|CRISPRCasFinder	1919927-1919954	28	NC_013037.1	3226874-3226901	2	0.929
NC_013037_7	7.1\|1919927\|28\|NC_013037\|CRISPRCasFinder	1919927-1919954	28	NC_013037.1	3229691-3229718	2	0.929

1. spacer 7.1|1919927|28|NC_013037|CRISPRCasFinder matches to position: 3226874-3226901, mismatch: 2, identity: 0.929

ctttaagcgttaggctttaagctgtaag	CRISPR spacer
ctgtaagcggtaggctttaagctgtaag	Protospacer
** ****** ******************

2. spacer 7.1|1919927|28|NC_013037|CRISPRCasFinder matches to position: 3229691-3229718, mismatch: 2, identity: 0.929

ctttaagcgttaggctttaagctgtaag	CRISPR spacer
ctttaagctttaggctttaagctataag	Protospacer
******** **************.****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_013037_3	3.1\|1176041\|29\|NC_013037\|CRISPRCasFinder	1176041-1176069	29	NC_011887	Methylobacterium nodulans ORS 2060 plasmid pMNOD02, complete sequence	116249-116277	7	0.759

1. spacer 3.1|1176041|29|NC_013037|CRISPRCasFinder matches to NC_011887 (Methylobacterium nodulans ORS 2060 plasmid pMNOD02, complete sequence) position: , mismatch: 7, identity: 0.759

tagcacaaatgtcgaatcgcaccgtttgt	CRISPR spacer
gggcacaaatgtcgaaacgctccgtccgg	Protospacer
 .************** *** ****..*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1029782 : 1051596

Bacillus_phage(33.33%)

transposase,integrase

attL 1047883:1047897|attR 1059558:1059572

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015810378.1\|1029782_1030094_+\|transposase	transposase	NA	NA	NA	NA
WP_143828657.1\|1030090_1030975_+\|transposase	IS3 family transposase	A0A1P8CWQ3	Bacillus_phage	6.0e-31	30.9
WP_143828658.1\|1031558_1031741_+	recombinase family protein	NA	NA	NA	NA
WP_015810381.1\|1031967_1033401_-	hypothetical protein	NA	NA	NA	NA
WP_143828659.1\|1034119_1035004_-\|transposase	IS3 family transposase	A0A1P8CWQ3	Bacillus_phage	6.0e-31	30.9
WP_015810378.1\|1035000_1035312_-\|transposase	transposase	NA	NA	NA	NA
WP_015810384.1\|1035499_1036360_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015810385.1\|1036450_1037356_-	alpha/beta hydrolase	A0A1D8EVD1	Mycobacterium_phage	5.0e-09	23.2
WP_143828660.1\|1037503_1038433_-	hypothetical protein	NA	NA	NA	NA
WP_015810388.1\|1038522_1038846_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_015810389.1\|1038910_1039696_-	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	9.1e-15	27.8
WP_015810390.1\|1039824_1040184_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_015810391.1\|1040158_1041409_-	condensation protein	NA	NA	NA	NA
WP_085938714.1\|1041921_1043029_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_187293428.1\|1043064_1043385_-	serine hydrolase	NA	NA	NA	NA
WP_050774616.1\|1043363_1043759_-	serine hydrolase	NA	NA	NA	NA
WP_015810392.1\|1044028_1044586_+	antirestriction protein ArdA	A0A222Z017	Rhodococcus_phage	6.7e-12	29.0
WP_015810393.1\|1044721_1045075_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015810394.1\|1045383_1046685_-	PQQ-binding-like beta-propeller repeat protein	NA	NA	NA	NA
WP_187293429.1\|1046685_1047612_-	hypothetical protein	NA	NA	NA	NA
1047883:1047897	attL	NA	NA	NA	NA
WP_143828662.1\|1047970_1048930_-	hypothetical protein	NA	NA	NA	NA
WP_015810397.1\|1049090_1049744_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_015810398.1\|1050285_1051596_-\|integrase	site-specific integrase	A0A1U9WS15	Gordonia_phage	4.4e-06	52.1
1059558:1059572	attR	NA	NA	NA	NA

DBSCAN-SWA_2

2318134 : 2388816

Acinetobacter_phage(25.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015811369.1\|2318134_2318542_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_041734881.1\|2318550_2319375_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	5.4e-18	32.1
WP_015810378.1\|2319614_2319926_-\|transposase	transposase	NA	NA	NA	NA
WP_015811371.1\|2320054_2320510_-	hypothetical protein	NA	NA	NA	NA
WP_015811372.1\|2320705_2321335_+	hypothetical protein	NA	NA	NA	NA
WP_015811373.1\|2322101_2322971_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_143828930.1\|2323011_2324385_-	hypothetical protein	NA	NA	NA	NA
WP_015811375.1\|2324466_2325555_-	membrane dipeptidase	NA	NA	NA	NA
WP_187293449.1\|2325560_2326436_-	3-hydroxyacyl-CoA dehydrogenase	NA	NA	NA	NA
WP_015811377.1\|2326479_2327778_-	aspartate aminotransferase family protein	NA	NA	NA	NA
WP_015811378.1\|2327774_2328758_-	3-hydroxyacyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_015811379.1\|2328769_2329153_-	reactive intermediate/imine deaminase	NA	NA	NA	NA
WP_015811380.1\|2329264_2330044_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_015811381.1\|2330081_2330987_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_041734883.1\|2330994_2331948_-	aldo/keto reductase	NA	NA	NA	NA
WP_015811383.1\|2331977_2332784_-	aldolase	NA	NA	NA	NA
WP_015811384.1\|2332879_2333839_-	hypothetical protein	NA	NA	NA	NA
WP_015811385.1\|2333855_2334644_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_143828931.1\|2334713_2335868_-	exo-alpha-sialidase	NA	NA	NA	NA
WP_015811387.1\|2335950_2337105_-	exo-alpha-sialidase	NA	NA	NA	NA
WP_041734885.1\|2337146_2338406_-	MFS transporter	NA	NA	NA	NA
WP_143828932.1\|2338461_2339490_-	hypothetical protein	NA	NA	NA	NA
WP_015811390.1\|2339554_2340319_-	phytanoyl-CoA dioxygenase family protein	NA	NA	NA	NA
WP_015811391.1\|2340361_2341840_-	RagB/SusD family nutrient uptake outer membrane protein	NA	NA	NA	NA
WP_015811392.1\|2341853_2345066_-	TonB-dependent receptor	NA	NA	NA	NA
WP_015811393.1\|2345414_2347358_+	BspA family leucine-rich repeat surface protein	NA	NA	NA	NA
WP_187293450.1\|2347390_2347531_-	hypothetical protein	NA	NA	NA	NA
WP_143828705.1\|2348745_2348979_+	hypothetical protein	NA	NA	NA	NA
WP_015811397.1\|2349546_2350953_-	TolC family protein	NA	NA	NA	NA
WP_015811398.1\|2352397_2353279_+	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_015811399.1\|2353284_2354346_+	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_015811400.1\|2354350_2354773_+	nucleoside deaminase	NA	NA	NA	NA
WP_015811401.1\|2355245_2355500_-	T9SS type A sorting domain-containing protein	NA	NA	NA	NA
WP_143828706.1\|2355503_2356415_-	hypothetical protein	NA	NA	NA	NA
WP_015811403.1\|2356426_2357680_-	hypothetical protein	NA	NA	NA	NA
WP_015811404.1\|2357655_2358708_-	right-handed parallel beta-helix repeat-containing protein	NA	NA	NA	NA
WP_015811405.1\|2358704_2359337_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_015811406.1\|2359417_2359855_+	cupin domain-containing protein	NA	NA	NA	NA
WP_187293451.1\|2359911_2360148_-	hypothetical protein	NA	NA	NA	NA
WP_015811408.1\|2363575_2363989_-	arsenate reductase ArsC	A0A2H4PQT9	Staphylococcus_phage	3.5e-26	48.1
WP_015811409.1\|2363995_2364490_-	N-acetyltransferase	NA	NA	NA	NA
WP_015811410.1\|2364513_2365080_-	hypothetical protein	NA	NA	NA	NA
WP_015811411.1\|2365134_2365464_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_050774673.1\|2365953_2366586_+	hypothetical protein	NA	NA	NA	NA
WP_015811413.1\|2366582_2366939_+	hypothetical protein	NA	NA	NA	NA
WP_085938715.1\|2367575_2368654_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_187293452.1\|2368695_2369601_-	PQQ-dependent sugar dehydrogenase	NA	NA	NA	NA
WP_187293453.1\|2369578_2370004_-	hypothetical protein	NA	NA	NA	NA
WP_015811416.1\|2370063_2370789_-	short-chain dehydrogenase/reductase SDR	NA	NA	NA	NA
WP_015811417.1\|2371114_2372437_-	glycosyl transferase	NA	NA	NA	NA
WP_015811418.1\|2372671_2373448_+	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	2.9e-13	29.7
WP_015811419.1\|2373941_2375447_-	choice-of-anchor E domain-containing protein	NA	NA	NA	NA
WP_015811420.1\|2376251_2376812_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_041736274.1\|2377874_2381834_+	response regulator	W8CYM9	Bacillus_phage	5.1e-13	35.9
WP_041734903.1\|2382214_2382985_-	hypothetical protein	NA	NA	NA	NA
WP_015811424.1\|2384051_2384810_-	DNA-binding response regulator	NA	NA	NA	NA
WP_015811427.1\|2386526_2387504_+\|transposase	IS481 family transposase	NA	NA	NA	NA
WP_015811428.1\|2388453_2388816_-\|transposase	transposase family protein	NA	NA	NA	NA

DBSCAN-SWA_3

6602078 : 6635582

Enterobacter_phage(22.22%)

integrase,terminase,portal,head,protease,capsid

attL 6594244:6594257|attR 6611144:6611157

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
6594244:6594257	attL	NA	NA	NA	NA
WP_015814905.1\|6602078_6603023_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_015814906.1\|6603248_6604322_-	asparaginase	NA	NA	NA	NA
WP_015814907.1\|6604362_6605133_-	TatD family hydrolase	NA	NA	NA	NA
WP_015814908.1\|6605135_6605756_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_015814909.1\|6605871_6607380_-	glutamate synthase subunit beta	NA	NA	NA	NA
WP_015814910.1\|6607429_6612010_-	glutamate synthase large subunit	NA	NA	NA	NA
6611144:6611157	attR	NA	NA	NA	NA
WP_015814911.1\|6612409_6612832_-	STAS domain-containing protein	NA	NA	NA	NA
WP_015814912.1\|6612882_6613818_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0M4JBD3	Mollivirus	1.0e-25	28.9
WP_015814913.1\|6613834_6614554_-	hypothetical protein	NA	NA	NA	NA
WP_015814914.1\|6614592_6615555_-	VWA domain-containing protein	NA	NA	NA	NA
WP_015814916.1\|6616390_6617467_-	hypothetical protein	A0A141E0C6	Streptococcus_phage	1.1e-26	27.9
WP_015814917.1\|6617638_6618040_-	hypothetical protein	NA	NA	NA	NA
WP_015814918.1\|6618052_6618862_-	hypothetical protein	NA	NA	NA	NA
WP_015814919.1\|6619327_6619570_+	hypothetical protein	NA	NA	NA	NA
WP_015814920.1\|6619566_6619755_+	hypothetical protein	NA	NA	NA	NA
WP_083769178.1\|6619738_6620041_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015814922.1\|6620424_6621324_+	hypothetical protein	NA	NA	NA	NA
WP_015814923.1\|6621320_6622244_+	hypothetical protein	NA	NA	NA	NA
WP_015814924.1\|6622437_6622866_+	single-stranded DNA-binding protein	A0A193GYD7	Enterobacter_phage	4.2e-06	33.7
WP_015814925.1\|6622877_6623078_+	hypothetical protein	NA	NA	NA	NA
WP_015814926.1\|6623110_6624259_+	hypothetical protein	NA	NA	NA	NA
WP_015814927.1\|6624478_6625339_+	DNA adenine methylase	A0A0K1LM14	Caulobacter_phage	3.7e-78	52.1
WP_015814928.1\|6625358_6625544_+	hypothetical protein	A0A219UQU1	Bacillus_phage	7.6e-05	51.1
WP_050774731.1\|6625540_6625966_+	ASCH domain-containing protein	NA	NA	NA	NA
WP_015814930.1\|6626187_6626904_-	hypothetical protein	Q5QF73	Pseudomonas_virus	2.8e-10	32.8
WP_015814931.1\|6626982_6627825_+	MYG1 family protein	NA	NA	NA	NA
WP_083769180.1\|6628460_6628769_+	HNH endonuclease	NA	NA	NA	NA
WP_041735584.1\|6628773_6629004_+	hypothetical protein	E9NIF1	Enterobacter_phage	1.2e-15	63.4
WP_015814933.1\|6629151_6629562_+	hypothetical protein	NA	NA	NA	NA
WP_143828827.1\|6629809_6630394_+\|terminase	phage terminase small subunit P27 family	NA	NA	NA	NA
WP_015814936.1\|6630374_6632099_+\|terminase	terminase large subunit	A0A1P8DTK0	Proteus_phage	1.0e-82	34.8
WP_143828828.1\|6632372_6633704_+\|portal	phage portal protein	A0A1W6JP33	Morganella_phage	9.3e-28	26.1
WP_015814938.1\|6633648_6634239_+\|head,protease	HK97 family phage prohead protease	NA	NA	NA	NA
WP_015814939.1\|6634265_6635582_+\|capsid	phage major capsid protein	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_013037

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection