CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_012914	Paenibacillus sp. JDR-2, complete sequence	11 crisprs	csa3,WYL,DEDDh,cas3,DinG,casR	0	7	8	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_012914_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012914_1

461004-461077

Orphan

Consensus_repeat	Method
GTAACGAAACTAGGTAACGTTATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012914_1

>merge|NC_012914|1|461004-461077|CRISPRCasFinder
GTAACGAAACTAGGTAACGTTATTTGGGCATTTTGAGCGGATTTGTGAGTGTAACGAAACGAGGTAACGTTATT

>NC_012914|1|1|461004-461077|CRISPRCasFinder
GTAACGAAACTAGGTAACGTTATT	TGGGCATTTTGAGCGGATTTGTGAGT
GTAACGAAACGAGGTAACGTTATT

Protein	Signature genes	Signature genes Name	Protein_function
NC_012914.1\|WP_012772396.1\|466418_467525_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NC_012914.1\|WP_012772392.1\|461211_463329_+\|alpha-galactosidase	unknown	unknown	gnl\|CDD\|269892
NC_012914.1\|WP_012772395.1\|465887_466229_-\|bacillithiol-system-redox-active-protein-YtxJ	unknown	unknown	gnl\|CDD\|274921
NC_012914.1\|WP_012772387.1\|453869_454703_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012914.1\|WP_012772402.1\|473753_474446_+\|CpsD/CapB-family-tyrosine-protein-kinase	unknown	unknown	gnl\|CDD\|349772
NC_012914.1\|WP_012772385.1\|451856_452822_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|226959
NC_012914.1\|WP_012772384.1\|450833_451853_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_012914.1\|WP_012772388.1\|454702_455593_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_012914.1\|WP_012772389.1\|455786_457640_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NC_012914.1\|WP_012772398.1\|468316_469120_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224098
NC_012914.1\|WP_012772382.1\|448104_449706_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_012914.1\|WP_012772391.1\|459443_460757_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NC_012914.1\|WP_012772390.1\|457632_459267_+\|response-regulator	unknown	unknown	gnl\|CDD\|381091
NC_012914.1\|WP_012772401.1\|473008_473773_+\|LPS-biosynthesis-protein	unknown	unknown	gnl\|CDD\|226453
NC_012914.1\|WP_012772383.1\|449856_450837_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_012914.1\|WP_012772400.1\|470713_472843_+\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|306825
NC_012914.1\|WP_012772394.1\|464427_465111_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238509
NC_012914.1\|WP_012772399.1\|469116_470187_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270381
NC_012914.1\|WP_012772386.1\|452940_453753_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_012914.1\|WP_012772397.1\|467514_468339_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224097

Protein	Function_ID	Function_description	E-value
NC_012914.1\|WP_012772396.1\|466418_467525_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	7.17916e-165
NC_012914.1\|WP_012772392.1\|461211_463329_+\|alpha-galactosidase	gnl\|CDD\|269892	cd14791, GH36, glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.	8.5227e-90
NC_012914.1\|WP_012772395.1\|465887_466229_-\|bacillithiol-system-redox-active-protein-YtxJ	gnl\|CDD\|274921	TIGR04019, hypothetical_protein, bacillithiol system protein YtxJ. Members of this protein family, including YtxJ from Bacillus subtilis, occur in species that encode proteins for synthesizing bacillithiol. The protein is described as thioredoxin-like, while another bacillithiol-associated protein, YpdA (TIGR04018), is described as thioredoxin reductase-like. [Unknown function, Enzymes of unknown specificity].	2.20642e-47
NC_012914.1\|WP_012772387.1\|453869_454703_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	6.60666e-64
NC_012914.1\|WP_012772402.1\|473753_474446_+\|CpsD/CapB-family-tyrosine-protein-kinase	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	1.19229e-85
NC_012914.1\|WP_012772385.1\|451856_452822_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|226959	COG4594, FecB, ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism].	1.81065e-92
NC_012914.1\|WP_012772384.1\|450833_451853_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	6.68815e-80
NC_012914.1\|WP_012772388.1\|454702_455593_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.77131e-78
NC_012914.1\|WP_012772389.1\|455786_457640_+\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	2.96485e-46
NC_012914.1\|WP_012772398.1\|468316_469120_+\|ABC-transporter-permease	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	3.17529e-78
NC_012914.1\|WP_012772382.1\|448104_449706_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.38429e-61
NC_012914.1\|WP_012772391.1\|459443_460757_+\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.01267e-45
NC_012914.1\|WP_012772390.1\|457632_459267_+\|response-regulator	gnl\|CDD\|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	8.2497e-47
NC_012914.1\|WP_012772401.1\|473008_473773_+\|LPS-biosynthesis-protein	gnl\|CDD\|226453	COG3944, COG3944, Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane].	5.81664e-62
NC_012914.1\|WP_012772383.1\|449856_450837_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	1.56607e-90
NC_012914.1\|WP_012772400.1\|470713_472843_+\|S-layer-homology-domain-containing-protein	gnl\|CDD\|306825	pfam00395, SLH, S-layer homology domain.	8.92167e-09
NC_012914.1\|WP_012772394.1\|464427_465111_-\|hypothetical-protein	gnl\|CDD\|238509	cd01038, Endonuclease_DUF559, Domain of unknown function, appears to be related to a diverse group of endonucleases.	0.000636833
NC_012914.1\|WP_012772399.1\|469116_470187_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270381	cd13663, PBP2_PotD_PotF_like_2, The periplasmic substrate-binding component of an uncharacterized active transport system closely related to spermidine and putrescine transporters; contains the type 2 periplasmic binding fold. This group represents the periplasmic substrate-binding domain that serves as a primary polyamine receptor of an uncharacterized ABC-type transport system from gram-negative bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, as well as plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.21398e-149
NC_012914.1\|WP_012772386.1\|452940_453753_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.54328e-29
NC_012914.1\|WP_012772397.1\|467514_468339_+\|ABC-transporter-permease	gnl\|CDD\|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	2.23578e-82

>NC_012914.1|WP_012772391.1|459443_460757_+|extracellular-solute-binding-protein
MFKRMASVSLSLALVGGMLAACGGNNGNDTANNGGTANNGAASDKPVTINMFTASPEYTDAFNAYIAEYKKVKPNVTINLEIMQADYNTVLKSKIASGSTPDVFQTTAGGDIDTFAEYSADLTNEPLAAAMTDGVRTNMTSSDGKVLGLPVKGNLMTLIYNKKLLTDAGIAEPPKTIAELNDDIAKLEAKKITPFANAYKEWWVWKHIFQHYVNAAAEDAGIAPKELVQQFIDGKTTFNDHPVLKDNFFNFIDLTVKHGTDKPLERDSNAEVSDFAQGKAAFMTGKGAWDEEAIKKISPDIQIGIAGYPVSDKPEQTQIVTGADQALRINKDSKVAREAIDFFNWLYTSDYGKQWFSNVAKVIPPIKDAPLPDLDMPKQMEEILKTQKSGDLSVNYSLDTFHQKFGEIMQAYIGGSKSKDQAIKEIQTAWQQFGSAE
>NC_012914.1|WP_012772390.1|457632_459267_+|response-regulator
MYKVLIIDDEEPLREAIRILGDWKGLGVAEVLEATDGKMGLEMIANHSVDLVMVDMKMPGMSGAELLQVLERDYPDMPAIVISGYNDFEYTRQAIRSKVVDYLLKPINRPDLNAALRKAVDLLEARRVRESEFINRNITLNMSLPKLKEKMYLSIIDRSFRSQTNEAFLPLIGADDPDNRFAAVVLRMLNMEKVRKARFHSDVDLLHFAVGNMLNEIAGEYFQAFSFASPKMDRELIVILTMKGAYQEDIAYRSLHQMNKALAALQDLLGIVAAAGIGTPCESIMEIASSYETAKAAINGIDLLKLKGYFVANAVAKSANEGYPVTGRMQMFRAALESGNTAGAKSILSEELRKWGGADLFTLGDADQSLGRFIILMNDISLELGVPREKLPLMEEHPVRFMGLSDDYASYEQFSKLLEDALHFYLEQLRLTQSANRPFEIGDIKAYIDNRYYEDIKISMFADKYFLSREYIMKLFKQQFGCGIHEYVQRIRMDKAKELLDDPSLKIQDISEMLGYKDKNYFSKAFRNYFSISPTEYRTARKEG
>NC_012914.1|WP_012772389.1|455786_457640_+|sensor-histidine-kinase
MAIANRIAKSWNALTERVSSRLVNKLILLFTTIIILVVGSLTFISYKMLQREALNNSIASTSNNLLLVNKNLEDYLAGMEQLSLPQINYDELAFAITHASTDYASKMYVEDYLRNMYFSRSNEDLEAIYLYFVRSGTYYTIAKENFDIKIRSGQADSIPTMSWYKQAMDSGTNQAYQSFLLSNEERGYDMDPSRSFMAYHRVLRSISTRAPQAVVSFYYNKSTINKIMKDIPEDTGQHLFFLSPDNVPFALDNRTSYESMVGSGLLKQIIKTDGTGANGLTWKSPEDNKYLVVYNVGAQEGWKLVKPIPYKELYAAAKTTRNLNFMIGLLFLLLAVVLITYFSNAVTKPLKLLSQQMKRFSTGDFEASTEVVGRDELAYLSRQFNQMVSQTNELITERYKMKLVEKNAILKALEAEINPHFLYNALQAISTKALKAERFDIADMVDALALTLRYCISGKDIVRASEELLHIERYMSLQKARFGGRLQLVIDWDQDLKELELPKLSLQTLVENAIKHGVEMVSSPVAIRISARAAGGHAFIIVNDNGPGFAPGRLKDVLESFEADWNERAEEEGSVGLVNLNTRLKLLYGTSSQLVIRTSPSGTEMEMLIPRGGGQHV
>NC_012914.1|WP_012772388.1|454702_455593_-|sugar-ABC-transporter-permease
MFKKMGRKVSEKIEFGLFTLPVLICIAIAFYIPFAMTIRYSLTKWNGISKHPKFIGLDNFKQIFLHDTNFTQSAWFTIKYAVLYIVLVNVLAILLALVLDMKLKSTTWLRAAFFIPYILSLVIVGFIWKFIFMQGFESLGASTGWGIFKLSWLGEPGLAFISILLVSIWQSVGFYLVIYIAGLQSVPDDLKEAATVDGAGPIRRFFNITLPLLAPSITISVFMALTNSIKVFDVILSLTGGGPGGTTYSIAYDIYRDTFQNNLYGYGTAKALILFVAVLIVTIIQLTIFKRREVEA
>NC_012914.1|WP_012772387.1|453869_454703_-|carbohydrate-ABC-transporter-permease
MNRQSKAGRIILEVVMVLFSLLFLYPLFLAINNSFKSFGEVMTDVIALPSKLAFGNYSHVWSFINYPKLFLNNFVITGVGLIGIVFVSSIAAYKLARTKSRWSGFLYLLCIMPMLIPFQSIMLTVLQLSKDLHITESTWGLGLLYWGFGAPLAVFIYHGFVKGIPKEIDESATIDGASGFRLFFSVIFPLLKSVTTTIIIIDVMWMWNDFLLPLLMVNGSPDTKTLTLAAYTFVGQYTSDWQYAMTAMVMAVLPSIVVFIFLQKYIVKGVVAGAVKG
>NC_012914.1|WP_012772386.1|452940_453753_-|helix-turn-helix-transcriptional-regulator
MSFEEINSLIPCLDYIEAYTRSTPLPAVLGQYHLIVVRRGHVTVFLESGESVICTQGYACHPGSGDYRIEVPRTKAAEYVIFTYRMLPLEQEWTLEGPLGTYSEVKIHYMVDELLRKMQEELPEEGRPEAAAFRYRTRLMLERILYIFLRESLMKKNEGSVARSIEDTITYMNEHYMLPLTLSMLAGRAGMSEGHYTVLFKKQTGRTMTVYLRSLRIEKAKQLFRQTRLPAKEIAQQVGFSDYFYFSRMFKKEVGMSPSEYLTSVKPNQI
>NC_012914.1|WP_012772385.1|451856_452822_-|ABC-transporter-substrate-binding-protein
MPFIRTSKFYVLALIAVLAFTLAACGNTGNNAGSAASEQPAQETAASGKIVVNDELGTVELDKAPEKIVVLEFSYADALVTLGVQPAGLADDDDPSLLMDEVKDKLGSYTSVGSRYEPNLEKISSLQPDLIIADSDHHKNVLDQLKAIAPTIVLNDHLADYDMALDNYLVIAKALGKEAEGQKRLEEHKATIEAEKQKIKETGYTILPAVVNPKGFFAQSDHSFAGSFLTSIGYADPVKNEEAYPQLSLEQLSETNPQVIVLLPTEEKTIVNEWEANPLWSKLDAVSGNKVLTAERRNWSLSRGLIGSEHIIKDIAAQLGE
>NC_012914.1|WP_012772384.1|450833_451853_-|iron-ABC-transporter-permease
MTTAASQGKQKRSAFLLFLFSFLLLIVGLVSSLKWGQSAVSWRTLYEAVTYQGSDKAHLYIQTLRLPRAIMALVVGVHLALAGLLTQLITRNPLASPHIFGINAGASLAVVIGLVAINGLSLLGSIAFAFAGAALGALLVWSLAGARQQHVRLALAGIAVHFLLSSLTEGMIVLNQHSTDSIMFWLVGSLSSVVWGDVHTILPFTVVSLIVLIPMIPSFRLLLMDDAVATGLGQRIAFVRTVGGILVITLAGSAVALCGPIGFLCLIVPHIARYLVGGRLALLVPLTGLLGGCMLVYADWISKFIAFPYESPVGIVTAVIGGPFFIYLARRSRSRGIAE
>NC_012914.1|WP_012772383.1|449856_450837_-|iron-ABC-transporter-permease
MRKGIYAIIVAAVLLLLLAALSLRVGAVSVPLREVWNSLTMQHSPDSFIVLQYRLPRVVIAVLAGIGLAVAGDILQGIVRNPLASPDVIGITKGAGFMAAAVIFLFPGAPSYALPLAAFLGAIIALVILLLLSRRMTLSPSSFALVGVAVGAVFQAGIQYLLVKHPSDVNMALLWMSGSLWGRDWQDVLSLLPWIAILTPVVWLSYPKLNVLQLGDEGSAALGLNVPRQRFILLLLAALLTGSSVAAVGSIGFIGLIAPHIARLFVGGRHQWLVPLSGLIGADLLLLGDVIGRVLIIPREVPVGITTAVIGAPYFIYLLRRERKNA
>NC_012914.1|WP_012772382.1|448104_449706_-|GGDEF-domain-containing-protein
MIYKIRPRKGFKLSSIISFVVILSVLITIFISTIIGYNTERRSLFNNTIELNGIAALNLSKTTQSLVISMQKSLKVTANYFSDIELNDKNVLSQLDFFMGTSPYFNSLTIVNKNGVIVSTSPNNLNLIGSKPTSEATTESLRLKKPYISKPFHAITNRMIVMVSSPIFDHNGNYKGFVGGSIYLQQANIFRDILGVQASTTSGSYFYVVDSSGYLIYHPDKDRISENVSGNPVVQKLMKGMSGAQRVINSQGQNFLAGFAPVPAAGWGIVSQTPQDHVTNISENVVQEMIKFSAPFVLLLVILSFWLSRKLAHPLNRLATYASRLSGGDEKLKPLQADVSWNYEANQLVDTVAVAFNKLRAQKEELHAEANTDALTGLTNRRTMGAITALWKQQGTPFSVIIMDLDHFKNVNDRHGHQMGDEVLKFVAGIMVSERGPDDYCCRFGGEEFTMLLPHATEAEAVQVAERIRLRIEQSVTPIGESVTMSLGVATFPDAAEEVVELFKYADQALYQAKRDGRNRTVAYSSLMNMARI
>NC_012914.1|WP_012772392.1|461211_463329_+|alpha-galactosidase
MEKLATAAGITKIEENGLHLVYEVRENGDVLLLHFGTQPWVEESITAKQKDGFRLMELQLTGEDRAEYHGRTHRASQPGLRMVYDGLTDSRNEFGRKLVLGLKDPVTGVSALWNVQFYDGVAVARCWTELVNEGEEEVGVEYVSSFALTGFDKDGEGDRDDKVTLTLAHNAWQSELQWRTYTLPELGMSHLIDRGSKRLAFSNTGSWSAAELIPMAIMSNTASGESLFWQIEHNGSWHWELTDQVDRLTLLISGPTEHDNHWWLKLAPGETFVSVPVAIGAVEGGVEEAAEQLTVYRRRIRRENDDNKLLRVIFNDYMNCLWGSPTTAKLLPLIDAAADVGCEYFCIDAGWYAPGEWWDGVGQWLPSEERFPEGIKYVLDYIRGKGMIPGLWLELEVMGINSPKLADTDDSWFFMRHGKRVKDRSRYQLDYRNPAVIAHADEVIRRLVEDYGVGYIKMDYNINAGVGTETDADSVGDGLLQHNRAYLAWLDGVFARYPELVIENCSSGGMRMDYSMLSRYSIQSTSDQEDYVKYASIAAGAPAVLTPEQAAVWSYPLREGDDEEVIFNMVNALLLRVHQSGHLAELSPRRRELVKEALDYYKTIRGDIREALPVWPLGLPAHGDDWLSLGLRRGNKLYLAVWRIGGEASELALPLPEHSGKQLAARCAYPAAAGDTGCSWDAAAGELRVTLSSPRTARLFELTLG
>NC_012914.1|WP_012772394.1|464427_465111_-|hypothetical-protein
MTVNDEYEEAHRRFIETHMEGRTGERRGRLARGHNFAEKLFLQNVWWPLLGNFEHLHPEYEVYDWNRKSQFVDFAYLPPQGMFAIECDGFQSHVKDMDRERFSYSLNRDTFLTGMGWKMIHFSFDDVQNHPEICMMLLKHVLGTHIIRGRQNVASLLVPSAERDILRFAFHMGGRVGPKDLSDHFGISFRTARKRLQSLSAKGMLKPIERGVQIRYYELNDRAIEHL
>NC_012914.1|WP_012772395.1|465887_466229_-|bacillithiol-system-redox-active-protein-YtxJ
MAQYREIDSMEGWNETFEASSDRPTVIFKHSTTCPVSANAYREFNEYLNGSPREDADYVLVKVIESRPVSLQIAEDTSVKHESPQIIFLEKKAKVWSASHWSITKEHITAVLD
>NC_012914.1|WP_012772396.1|466418_467525_+|ABC-transporter-ATP-binding-protein
MSDQTIIRFEQVTKQYDDQTTVLSEVSFEIERGKFYTLLGPSGCGKTTILRLIAGFIEPSKGQIYFNGKVINRIPPNERQVNTVFQDYALFPHLNVFENVAFGLRIKKLKNAAITAKVKEALRFVNLEGYETRNISEMSGGQRQRVAIARAIVNEPEVILLDEPLSALDLKLRTEMQYELRELQRRLGITFIFVTHDQEEALAMSDEIFVLNQGKIEQSGTPNDIYDEPINRFVADFIGESNIVPGRMKQDFEVEFAGRAFECVDQGLNPNEPVEIMIRPEDLEITTTEQGKLQVRVDSQLFRGVHYEISCYDEAGNEWLVHSTKKAAVGEQIGLYFDPEAIHVMRFGETEEEFDKRLDAYSEGQDEN
>NC_012914.1|WP_012772397.1|467514_468339_+|ABC-transporter-permease
MRTNTRNFYLIPYLLWIALFVITPIVLVVYYSFFDVEGDFTFGNYQKFFTPVYMKMTLSSFWYAFLITAFSLLVAYPAAYLLTRTKHKQLWLLLIILPSWINLLLKAYAFLGLFGTYGAVNGMLKFIGIGTQQILFTDFSFIFVSVYIFIPFMILPIFNSLEEMNPSLVFAARDLGASPWTAFRRVIFPLTLSGVKSGCQAVFIPALSLFMITRLIAGNRVITLGTAIEQHFLVTQDWGMGATIAVFLIIAMAVIMLLTGSRKRGLQNENRKAV
>NC_012914.1|WP_012772398.1|468316_469120_+|ABC-transporter-permease
MKTAKLSNVYLIAVFIILYAPIFYLIFYSFNSGGAMRNFEGFTLEWYQEVFADTRLLIIVLNTFVIALLSSAISVIFGIAGALAIHYVRRRQPKNALLSLNNVLIVSPDVIIGASFLIMFTIIGIKLGFVSVLLSHIAFSVPIVVIMVLPKLQEMSPTLIDAARDLGASSWHVLTRVIVPFIKPGIFAGFFMALTYSLDDFAVTFFVTGNGFSTLSVEIYSRARQGIALSINALSTLIFLFTILLVIGYYFINQRNNRTSARSEGRR
>NC_012914.1|WP_012772399.1|469116_470187_+|ABC-transporter-substrate-binding-protein
MKSLVQTFIAVLVVSFGLMYLTSYLNSSAGYTGKDTLTIYNWGDYIDPELLDEFQKETGIKVIYQTFDSNEAMMTKIEQGGTTFDVSIPSEYAIDKMKEENLLIPLDKSKLPNLKYIDPSFLNLSFDPDNKYSIPYFWGTVGIVYNPDLTDLKFHSWNDLWDPSLKNQILLLDGAREVIGMGLNSLHYSLNDTNEEHLQAAKAKLSTLTPNVKAIVGDEIKLLLANEEAAVGLVWSGDASEIMSENEKLDYVVPEEGSNLWFDNMVIPKTAKNIEGAHKFINFMLDPEHAAQNAEYVGYSTPNAKALEYLPEEISGDKRFYPDKELTEKLEVYKNLGKKMLVHYNELFLEFKMHRK
>NC_012914.1|WP_012772400.1|470713_472843_+|S-layer-homology-domain-containing-protein
MTIKKKIIVSTIAASMAATAFAGIPLSSKGLAEKLGFSNTAYAATSSTDQLIAEANKWHDALGVSGLATLKTLRDVIKGLTPAEVKAIVLPVTSSIATKYSLSTDEKIAIEDLYINLLGFTYTADFSYFDGIQSSAGFDVLRTLADEADVSGLTFEDLAAYVLKVKTNLFASLDALSVSQVQALATNPLGVVTLVQNAIQAVPDTNDTASKLKQVFNYYGINQSKLTEAAGNLVVKVTTVNSTAIPNAINAVITAYLNTRNTGTGPSVPSTGDEDTGTVKVPTEVTELLGKLKDKLANATDAEKAAILAEAVQQATALVTKLSTFDLSGDVKVSNGQASVQVSSSSVLSAIAGIGEILKNVKELAPGVTVPAPILNLNLGNVAQDDVKIGLNNALIQEAIKAGLGGINLTVNGLSAVLPVGGQFNGAVDFNINKSKADSSTTGELKAASDVYSFGLTIGGQSVTSFAQPVTVAIPLGNVDGVDKELLSLAKIVDGKLVFQGGTVEGNLIVEHRDTFSQYVVVENKVSFTDIASVQSWAGRAIEVIAAKGAIEGKKAGVFAPKDNVTRAEFAKMLTRALDIDNSSAKEDFADVKDTDWSAPYIGAAAKLGIIQGRSATKFDPNAQITRAEMATMIARALKVTKGAQDVTDVTAALASFKDASSISASLKAGVAFASKNGIVIGNNGKFSPNASATRAEAAVMIYRAVNFK
>NC_012914.1|WP_012772401.1|473008_473773_+|LPS-biosynthesis-protein
MSEELDLREYFLIVRKRLLLIVIFVLVCTVASGVYTKMFKDPIYEASTKIVVNQPSQQLAVGQLDLNQINSNIKMIDTYKEVIKTPAILGKVAEKYPQLGLSAKELTKKISVSSVNGTQVMTLAVQDVSYQQAAKIVNAISLVFQQEIPNIFQVENVSILNEALLDDQPAPVSPNVTLNIIIAFVVSLMIAVGIAFLLEYMDDTIKTETDVQRYLGQPTLAMVARVEASEFQTGSSRTENRQKAGGLENVTIGE
>NC_012914.1|WP_012772402.1|473753_474446_+|CpsD/CapB-family-tyrosine-protein-kinase
MSQSENKRRLISVANPRSPVSETYRTLRTNIEFAAIDSALQVIMVSSAGPGEGKSTTIANLAVTFSQSDRKVVLIDADMRKPTAHKTFQISNRFGLSSVISQQSTLQEVIQATDIPNMDVITAGPIPPNPAEMLASKRMTALLDELRTMYDIVLVDTPPLLAVTDAQIAATKSDGVVLVVDQGRVKRQFAQKAIQNLQNVNARILGVVLNNVKRRSNEEAYYYYYSADVK

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Crispr_ID: NC_012914_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012914_2

515503-515608

Orphan

Consensus_repeat	Method
ATGCTCCATATACTGCATATCGTGCAACGTAGGCGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012914_2

>merge|NC_012914|2|515503-515608|CRISPRCasFinder
ATGCTCCATATACTGCATATCGTGCAACGTAGGCGGACATCGGCACTTAAAGCCAGCTACTGGGCTCAAATGCTCCATATACTGCATATCGTGCAACGTAGGCGGA

>NC_012914|2|2|515503-515608|CRISPRCasFinder
ATGCTCCATATACTGCATATCGTGCAACGTAGGCGGA	CATCGGCACTTAAAGCCAGCTACTGGGCTCAA
ATGCTCCATATACTGCATATCGTGCAACGTAGGCGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012914.1\|WP_012772440.1\|515784_517593_-\|5'-nucleotidase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|236566
NC_012914.1\|WP_012772442.1\|518911_519601_+\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|234784
NC_012914.1\|WP_012772441.1\|517932_518883_+\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NC_012914.1\|WP_012772444.1\|521640_522348_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_012772445.1\|522574_523444_-\|aldose-epimerase	unknown	unknown	gnl\|CDD\|185702
NC_012914.1\|WP_012772431.1\|503190_504822_+\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_012772447.1\|525009_527061_+\|bifunctional-diguanylate-cyclase/phosphodiesterase	unknown	unknown	gnl\|CDD\|236645
NC_012914.1\|WP_049790108.1\|510008_510863_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_012914.1\|WP_012772446.1\|523626_524805_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|234605
NC_012914.1\|WP_012772433.1\|506707_508078_+\|response-regulator	unknown	unknown	gnl\|CDD\|381091
NC_012914.1\|WP_012772437.1\|511814_512687_+\|family-43-glycosylhydrolase	unknown	unknown	gnl\|CDD\|350118
NC_012914.1\|WP_012772443.1\|519804_521205_+\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NC_012914.1\|WP_012772436.1\|510912_511791_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012914.1\|WP_150106595.1\|527152_528496_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NC_012914.1\|WP_012772439.1\|513349_514561_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NC_012914.1\|WP_012772432.1\|504968_506711_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NC_012914.1\|WP_012772430.1\|501512_503159_+\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_012772449.1\|528609_529599_+\|L-glyceraldehyde-3-phosphate-reductase	unknown	unknown	gnl\|CDD\|381377
NC_012914.1\|WP_012772438.1\|512879_513350_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|377622
NC_012914.1\|WP_012772434.1\|508257_509889_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270298

Protein	Function_ID	Function_description	E-value
NC_012914.1\|WP_012772440.1\|515784_517593_-\|5'-nucleotidase-C-terminal-domain-containing-protein	gnl\|CDD\|236566	PRK09558, ushA, bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed.	4.98372e-119
NC_012914.1\|WP_012772442.1\|518911_519601_+\|deoxyribose-phosphate-aldolase	gnl\|CDD\|234784	PRK00507, PRK00507, deoxyribose-phosphate aldolase; Provisional.	5.26279e-123
NC_012914.1\|WP_012772441.1\|517932_518883_+\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	1.54795e-106
NC_012914.1\|WP_012772445.1\|522574_523444_-\|aldose-epimerase	gnl\|CDD\|185702	cd09025, Aldose_epim_Slr1438, Aldose 1-epimerase, similar to Synechocystis Slr1438. Proteins similar to Synechocystis Slr1438 are uncharacterized members of aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism, catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen.	1.33117e-90
NC_012914.1\|WP_049790108.1\|510008_510863_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	4.10373e-111
NC_012914.1\|WP_012772446.1\|523626_524805_-\|peptidylprolyl-isomerase	gnl\|CDD\|234605	PRK00059, prsA, peptidylprolyl isomerase; Provisional.	1.08877e-45
NC_012914.1\|WP_012772433.1\|506707_508078_+\|response-regulator	gnl\|CDD\|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.45608e-47
NC_012914.1\|WP_012772437.1\|511814_512687_+\|family-43-glycosylhydrolase	gnl\|CDD\|350118	cd09004, GH43_bXyl-like, Glycosyl hydrolase family 43 protein such as Bacteroides thetaiotaomicron VPI-5482 alpha-L-arabinofuranosidases (BT3675;BT_3675) and (BT3662;BT_3662); includes mostly xylanases. This glycosyl hydrolase family 43 (GH43) subgroup includes enzymes that have been annotated as xylan-digesting beta-xylosidase (EC 3.2.1.37) and xylanase (endo-alpha-L-arabinanase, EC 3.2.1.8) activities, as well the Bacteroides thetaiotaomicron VPI-5482 alpha-L-arabinofuranosidases (EC 3.2.1.55) (BT3675;BT_3675) and (BT3662;BT_3662). It belongs to the glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) which includes family 43 (GH43) and 62 (GH62) families. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	2.4287e-123
NC_012914.1\|WP_012772443.1\|519804_521205_+\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	2.28581e-127
NC_012914.1\|WP_012772436.1\|510912_511791_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.53967e-59
NC_012914.1\|WP_150106595.1\|527152_528496_+\|HD-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	1.91037e-72
NC_012914.1\|WP_012772439.1\|513349_514561_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.49634e-87
NC_012914.1\|WP_012772432.1\|504968_506711_+\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	1.13446e-45
NC_012914.1\|WP_012772438.1\|512879_513350_+\|cupin-domain-containing-protein	gnl\|CDD\|377622	pfam06172, Cupin_5, Cupin superfamily (DUF985). Family of uncharacterized proteins found in bacteria and eukaryotes that belongs to the Cupin superfamily.	8.32231e-60
NC_012914.1\|WP_012772449.1\|528609_529599_+\|L-glyceraldehyde-3-phosphate-reductase	gnl\|CDD\|381377	cd19151, AKR_AKR14A2, Salmonella enterica aldo-keto reductase (AKR) and similar protein. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).	0
NC_012914.1\|WP_012772447.1\|525009_527061_+\|bifunctional-diguanylate-cyclase/phosphodiesterase	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	1.0572e-114
NC_012914.1\|WP_012772434.1\|508257_509889_+\|extracellular-solute-binding-protein	gnl\|CDD\|270298	cd13580, PBP2_AlgQ_like_1, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	2.09719e-107

>NC_012914.1|WP_012772439.1|513349_514561_+|MFS-transporter
MKPAEKLWTKNFILLACSNLFLFFGLEMLLPTLPLFADEKGGSGSQIGMMLGIFTFSAVVSRLLIGIGLKHFGKRKLLLIGVTICLIGMACYYAADSISALLALRVVHGFGFGIATALYGTLVSDAIPAERRGEGMGYFAMGNAVSFSIGPMLGLWLLDQYDYAGLFGAGVVFLAITLVLTLLVRQKSAQSVEIAAAEAAAAAELHAAGVKPSPWAEVIEPKVLVPSMLGSLVGFAFGGMLSFVTLFTKDIGITQTGYFFLVVAISEVLIRFISGPLFDRKGPFWVLFPTAILCMIGCVLLYYTDSMAMLLLAGVFYGAGFGAMFPALQAWVINLVQPERRGVATATYYNFFDIGIGLGSILLGVVVTATSYTTMFLLSGILYVIYLAVYFIYLSRQRARAQG
>NC_012914.1|WP_012772438.1|512879_513350_+|cupin-domain-containing-protein
MSATAVKEISPLVAALELKPHVEGGWYKEIWKANFEIPQAVLGEPYSGPRFAASSIYFLLHPGEFSDWHTVHSDELWLWHSGSPLMLTLGGTGENPEVRKEIIVGGDVANGQHPQALVPATEWQMARPLGDEPVLVSCIVAPGFHYDDFKLIERKF
>NC_012914.1|WP_012772437.1|511814_512687_+|family-43-glycosylhydrolase
MQINNPILPGFWADPFILRDGEDYYLYPTKDSAGWMYEKFHVFHSKDLVNWDGPYLALDLNDVSWADKQAWAPGIAKYKGKYYMYFSAEAQIGVAVSDSPLGPFKDMLDRPLITRNQYHCQSIDADLFVDDDGQPYLLWGQGKCWIVPMEEDMTTFKSEPVQLSVQIHNSKGSDAAAGDIAVYNEGPHMQKRDGRYWLTWSNYDTRDPRYQIAYAFSDHILGPYEVPENNRMTLESVSAVGTGHASLTEFENEWYLIYHRLAEPETSVLRETCIGLVRFKDGQPYVDVDE
>NC_012914.1|WP_012772436.1|510912_511791_+|carbohydrate-ABC-transporter-permease
MPLTGKRGIRTTDIVLTLVMLLITLLCLLPLVNVVSLSFSGKSAAASGAVTLFPKDFTFYSYEYMFKDSRFFDAFGVSVKRVLLGGAINFVLTIMMAYPLAKERQEFRGRDIYMWVIVFTMMFTGGLIPWYMVVKSLHLTDTIWALVLPTAVPIFNVILLMNFFRGMPKEINESAKMDGAGPWRTLITIAVPLAMPAIATVTLFSIVSHWNAFFDGLILMNKQHNIPLQTYIQQLVVAPSITSSTRPEDLINFSQRTFNAAKIVVTMLPILIIYPFLQRYFVHGITLGSVKE
>NC_012914.1|WP_049790108.1|510008_510863_+|sugar-ABC-transporter-permease
MLAPGMILLVIFGIVPLFGMAIAFQDFIPVKGIWGSKWVGLENFKYMFELDDSKTIFFNTIFISVMKMLMNVLIPVSTALLLHEIVFNRLKRWMQTIIYLPHFLSWVILAGILTDMLSQNGIVNQVIKSITGEPIFFLGSNNWFPVVVVLSDVWKEFGFNTIIFIAALTAINPSLYEAASIDGAGRIRKIWSVTLPGILPTIILVSTLNIGNILNAGFDQIYNLYNPLVYESGDIIDTYVYRIGLVQYQYGLATAVGTLKSVVGFILIFVSYRLAARFAGYRIF
>NC_012914.1|WP_012772434.1|508257_509889_+|extracellular-solute-binding-protein
MKKALSILIISALMVLAACSGNNGNANSGNNAGGNASNGGTAEPADPYAPMSETVTISIGKEAAVDPKLPSGSTIEDNELTRYFAEKLNVKYTNEWQATGDAYTQKVGLTLSTGDIPDVMIVDKQQLVQLVNADLIEDLTSTYKSFVSPSLKAAYDSTNGYSLASATFDGKLMAFPNVSPGADAQNMVWVRQDWLDELQLEAPKTMDDVINVTKAFMDKKGSVGLLGNQVIVNIGTSVFGFDSIFSAYNAYPQLWTKDASGNTVYGSIQPEVKEALAKIRGWVQEGVIDKEFAVKKNEQVNELVVSGKAGIFFGPWWLPFGVLADSVAQDSKAEWVSYLAPLDQEGKMNTHMASPTTRYLVVKKGFKHPEAVLKTLNMQFDTDQLQGEGIVQKDAYNWMNMPFSLLLSNYDDKEKKAKLVQDVIDGKAGADTLQGEAKQIYNSYLKDKENPKKDLAAWSQRHAFLTGALPLIQDDKINRNVGVYYDQTDTMRTKWANLRKLEDETFLKIIMGNEPVDSFDSFVGKWKSQGGDEITKEVAEAAK
>NC_012914.1|WP_012772433.1|506707_508078_+|response-regulator
MKVIIVDDEKLVRRGLISMMPWSKYDMEVVGEAGNGRKALELLETLEVDLVFTDLMMPEMSGFELIEEMNGKYPAASAVVLSCHEEFSFAQKAIRLGAIDYIVKNDLETDVMDEVLERVAHSYEEKVKARPVPEVRTFDRVMVVLELEEVEKAGQLIRKLSAGHIIHYLERRCWFLSLDGVGKSEEQSLINDIKEANCLPVLVHGLGHESLSGAVDKLHGYLAAGLLYDFTKMLRFWEWRADEEKEPLNPEKIQLGERWNKLEWIYSNETYEELLRDTTAIRLPMSELKSLLFPALLESGRLLLMVEWSMQLIFRLEPLRMWEECRSVLDEERDKLRSIVCRTKYSDDILRVIYKAIQYMHEQEEMDFSQNEIAGIASMSRTYFSQCFKNVTGKSFNDYATEIRMSRAKKLLAHTNTPIYQIAQLVGFKDEKYFSKLFMQEIGVLPSDFRKQWERE
>NC_012914.1|WP_012772432.1|504968_506711_+|sensor-histidine-kinase
MDEREVPYIKRLFGWDTLRGQLYWTLLVSSVIPLVLVGILTVYSIYNILYNKIEKGIEQNLQRVSRSLEETLENLYDVSQQMSYQGFVGRDMEALQTSEDNYEKSQLVVNIQRNMGILNASNPTIGLVFYYDTTTGEIQYNNYITRDLHPDFDSLPKLSVHSDHVFNGPHLTLYKYNDIPVFSIVRSVGGITDPGNPLLVYAETNVSVIKNILNKEQYGMKVSHLLMDKDGTVLFSDKPELTPIGSTYDPGKLKRYYFHEVTGSQGWRLGVFVEKGEYQKEIRDWFVKYAFIVVLGLLISIWSAFRTWKVVISPLHRIRKGISAVISQEPNANFQMTGLREFDFLIQNFNDMQFRIQKLIMEVAKEASEKQEIEMEKLMAQINPHFLYNTLNTAQWLARLKGQHEIDRFLSLFTKVLKYNLAKDGAIVTLKDEIESLNDYVELQKIRYDFEFDVRYSIPEPFLATPLPRFILQPIVENALYHGMMDEKGIIEVTAEEREGMLVLMVKDNGNGISPEKIKELLESDTRKNNISGLGIGLNYVVRTLSSFTGGASQLRIDSQIGEGTTVSIHMPMHEEEAKP
>NC_012914.1|WP_012772431.1|503190_504822_+|hypothetical-protein
MPVRSSILRLLFIASGACMTALLTLRGSAVNVLIGLLCSLLLLYWLTYKRQVVEKVTQELSPGRIFFAALFTLVGVYYLTQYSYIKYSKLSGEVFDRIGLDIGGHNDKVISIALGICSLLAVFLVLCWFLPKFYATAKELITGLDRLERRYWIIASIIMAVAILIIYNLTNVFYGAHDAAGKIIPYDVVYTADSIDQVESNAFLNIGTYENDIRQPLFGLYAAPFALIAMILSKVLFFIPNSYPIMMQIIHVFVMQFAMILLARMMKLQSMDKVFFLLFMSFSYPFLLFMLNIEQYIFAVFWLILFIYSYLFQWGRRDFFFIGAVGSLVTTGILFPLLSQARKLKEWIKDMAVNAFKFLAAATLFGQLPVILETHTEYKGLMAFSGAEVTTLDKWYQYVNFFASCFVWPSAGEDRTTFEHASYQLRLVDSLNILGVIILVLAVIGFLLHYKDRFAQICMFWLAFSFVILFAVGWGTKENGLILYSFYYSWALFALIFKLANRLLARVQPLKFGVYGLLLGVMAVINLIGIYDLIDFGIRNYPA
>NC_012914.1|WP_012772430.1|501512_503159_+|hypothetical-protein
MTTVTAKAHLMKGAFILSGTAMTGLVSLKGTAFHVAIGVLCSFLILCWAAYTSGYLNKVIPVIRKKDILLPLIFAVAIDVSMIDYFYKQRTLKNVREMLQDSGYMPYSDEIAAAISIIVGIVAFYFLFLCVYLLWPKLAAVVLEFARNLTKLEKRYLIISTLLLAVVVIIAFNVSSVFYETRDQSGELVRFDVVYTTDTADLVDSNVYLNISSVQNDLKQPLFGLFALPFALVGVVISKLLFFVPNSYPVMMQIIQVLLLQMAMILISRMLKLRSIDQLIFLLFLNASYPVLMFSLNMEQYIFSLFWLILFLYSCQFGWGPKVYYFIGAAGSLLTSAVLFPLLSKSKQLKGILKDTGRVALQALVIMVLFGRLPLLLEVVSSVKENMEFTGAAISSGDKWLQYVNFVASCFVKPGAGVDKTTFEHVSYQLHAVHSLNILGLILMILAVAGFLLHYKQRFMKICVLWVSFSFVMLCVVGWGTAENGLILYSLYFSWAFMALLFMLIDKLLARHHWVKYSVHALLLVVMIGLNAQGLYDLIRFGAEYYPV
>NC_012914.1|WP_012772440.1|515784_517593_-|5'-nucleotidase-C-terminal-domain-containing-protein
MLIKLRKMKWAAGMLAASLFAASVGVVAAADETAVPASAKHITLLHTNDMHARAVEGNSGEMGYAKLAGIIDSYRKANPESLLLDAGDATHGTTFATLVNGESVVQVMNKMGYDAFVPGNHDFNYGYKRLLELEQMMKFPVLSANVKVAKDNTSLFKPYIIKEVDGVKIGIFGLTTPETAYKTHPKNVEGLTFADPTKEAQAIVDELKDKTDVIVAVGHIGQDASSVDTSLKIVKAVDGIDVFIDGHSHTVLEHGLTAGHNTLIASAGEYTKYLGVVDLWVDGGKVVKKEAKLENKDTAASIAPNAEIADMVASIQKSQETILAEEVGTASVKLNGEREQVRTSETNLGNLVADAIRDAAGADVAITNGGGIRASIDEGTITKGEIITVLPFGNQIVSLKVKGADIKAALETGVSDYPNSKGGFPQVSGITFKIDVAKPKGQRVHSVTVKGKPLNEKADYLLATNDFMAAGGDEYTMFTPYPQAGMYGSLDEALIAYITKLGTANSKVEGRITAAATPVVAQPQPEPKPEPKPEPKPEPKPEPKPEPKPEPAKPAVYVVKQGDTLWAIAKKNNTTWQKLRDLNHIKNPNLIYPGQKIKLPAA
>NC_012914.1|WP_012772441.1|517932_518883_+|sugar-binding-transcriptional-regulator
MEELSDKRLKMIEAARMYYELDYNQQEIAKKLGVSRPTVSRFLQQAKEDGIVQIRIMDPASDNQERARMLKERFGLKEAIVASVPKYEDAMVKKVIGEAAANFLNDTVQDGDTIAVTWGTTLYEVASRLPNKHTKKVKVVQLNGGVSHSETNTYAYEIAQLFAKAYQTSPYLIPLPAIVDHAVVKHAIEADRHIRKILDMGKQANIAVVTVGAPTEDSVLIRANYFSDEDLGIILSRGVGDICSRIIDINGQLCSEELDHRTIGIDLNELKKKEWSVLVAGGPSKVEAIYGALNGQYTNTLITDQITAQHLLEFKG
>NC_012914.1|WP_012772442.1|518911_519601_+|deoxyribose-phosphate-aldolase
MSNQKNLSAGEVAAYIDHTALKAETTKQEIIKLCEEAKQYHFATVCVNPGYVALAAKELAGSGVGITTVVGFPLGATTTFAKAEEAKDAIANGATEVDMVINVGLIKSGDFEGVKKDVEGVAQACKGKAVLKVILETGLLTDEEKVRACEICKEAGADFVKTSTGFGKGGATAEDIALMRRTVGPDLGVKASGGVRDLETALKMIEAGASRIGASSSVAIVTGGQGEGY
>NC_012914.1|WP_012772443.1|519804_521205_+|SulP-family-inorganic-anion-transporter
MSLKTSWREQWTGNVRMNVLAGITATLALVPDSLAFSFMAGVPPVVGIYASICILLVITFLGGRPGMISAAAGSMAVLMLTLVKEHGIEYLFAATVLTGIIQFLMGVFKLGKLMRFVPSGVLTGFINALAIMIFLSQLRYFKGESWVMYVLVAVTLGIIYLVPRFFKAIPSPLIAVVVLTLAVWAFGMGDVTRIGDIARIDASLPSFLFPDIPFSLDTLWIILPYSLSLAVVGYTETMLTHNLLDEMTGEKTDKNREMKGQGLANIVAGFFGGMAGCALVAESVLNVKMGGKNRLSTLVAALFLLLLVVLLGDLLSLVPMAALVGIMLMVCIAIFDWSSVFRMNRLPLGETVVMLVTVGAVLLTHDLAIGVVAGVFVSFIGFAVKASKVHIHDEWNGSTRTYRVHGQLFFASASELEERIEHDCEAEEVRIDLSGTKVWDHTANLAVRKTVDRLQKNGKQVTVVGV
>NC_012914.1|WP_012772444.1|521640_522348_-|hypothetical-protein
MTDIEQTIALITKSSGRRSAYHFTRASNLQSIARFDSIWSSQHLLPKSTGERRVAREVVSYEGASITVNSHLRIPEAMMETGCSVEEFRNFIDKHVFFWPTARDCLKMLTTYMRREPDEAFAVLEFEASELLLEHKESVRLSKYDSGSSPRFPKSCNYRKSPAMFVTLADFGRRTDYAVPVKPSEIKEILIEKQAHFVTRLLKSVYAPTQEYVPPAWLPNYQPLDRLLPVDETEA
>NC_012914.1|WP_012772445.1|522574_523444_-|aldose-epimerase
MSQFQVTSYTDTFKIYELIEESTSSRIRVCPERGGIVIGCQLNGLEVFYLDKATFDHPTANIRGGNPILFPICGQLENKTYTWNGQSYEMANHGVARTSVWEVAGTSTDGEASITIVLRSNEETKQSFPFDFEVSFTYALVNGELHIRQQYRNLTEGETMPFYAGFHPYFNADSKKLPYETDATTYLDYNDMVEKPYTGELDLDGMVESVTLLGAEKREIAFPVSGGARVRMTYDDIFKYVQVWSVQDKPFVCVEPWMAMTGELNRQEELVMLQSGEALNCNLTISCER
>NC_012914.1|WP_012772446.1|523626_524805_-|peptidylprolyl-isomerase
MENKDSQHKRENEELDTAAEQENQQYVYEDDNKDDQHVDALQDEKDEEVEEEERKQAPTSETPAQAAGGRSGGKAWIAVSAILAIVLIIVLIKPPFGAGDKAVATVNGAKITKDKLYDSLVEQGGKSTLDNMITTELIDQAAADAKVTVTEADVDKEIENLKKSFGSEDEFNQTLAQYGMTVDSLREDAEVQVKIRKILEPQVKVTDDDIKAYYDANKASMSTPEQIRASHILVATKEEAEDILKQLKAGADFATLAKEKSTDTGTKDNGGDLNFFGKGSMEPAFEDAAFALKKGELSGVVQTSYGYHIIKKTDEKAAVTPTLEEKKEDIKYQLVTQKVSELSSTWMADLKAKAKITNTLDPAAAEESPAASADASPEASAAAGNASTNTAK
>NC_012914.1|WP_012772447.1|525009_527061_+|bifunctional-diguanylate-cyclase/phosphodiesterase
MVILHGEYNGWVILLSFIIALFVSYSALNLVYKISQSKGKVQLGWMLAGAFVMGSGVWTMHFIGMMAFHIGIPISYNVPITLLSITASICASYVAFYLTLAKEINRLKLLGGGFIMGAGIVAMHYTGMASMHSPTMSIQYNPIIVVLSAVIAILASCAALYFFINFRDGSKAVWSKWAAASLMGLAVCGMHYTGMGAASFWCGEPIASSLTENIPINLFLLISVTLVTLLIMLVTWIAIYLDRTVLERMAYSDPLTGLANRHAMNRYFDQKLDKARSYGLLFLDLDQFKIINDTLGHDIGDLLVQAVAKRLRSHVSEGAQTFRLGGDEFLLVTRGMEPSEVEKLANRILEDIRKPYLLEGNELYITGSIGISLSPQHGIERSSLLIAADTAMYQAKRRGKNQYCLYDEQMERELLRRMELEKDLRLALPREQFVVHYQPKWDAAANRAIGVEALLRWNHPLLGRIPPEEFIPIAEETGLIVPITRWVLGQACRDCFEWNEGRAEPLSVSVNMSVSVFDSKNLEDMVISALLHSGLDAHLLELEITETIVMHNVEDVIEQLNPIREMGVQISMDDFGAGYSALGSIDLIPFQTLKIDKLYMQQSDSPSKRAIIQTIIILAKQLNLEVIAEGVETEQQIAFLQSAGCSMMQGYYFSKPMSRADLDLWLQQSMVIDRSQTSQSLIG
>NC_012914.1|WP_150106595.1|527152_528496_+|HD-domain-containing-protein
MVLHMNPAWDYHLHSPNGHFYVVSIVSGLAFALAIAVGVAAIRLRNLKISFLSLSFVSLAALFLVHGLSTPREAYHTTALPSNAAQMSILLAVMWLWLSSMSSDRRIISWLSTHQRWLLPIWTASIAVICALLWLFSDQMSWLQMKQGPIKWTATLLIIGLNGWTMYRYLETYLSTRFPLQLAIVYSSGWMIAAQFINVMGKMWMLSWWIYHLLLLASISAMIIGIYYQYRSSGSYTMSLKQLFQNDPKEWIHTYMSPAVRELIRTTETRDAYTAGHNYRVALYAIQLGEELGLNSDQLRAIAQGGIVHDIGKLIVPDNILNKPGKLTPEERDIIEKHPVTGFNLCRRLGFMQEELAVIRSHHERWDGSGYPDALSGDNIPLLARVTAVADVYDALTSSRSYRAALSHEEAMTIILKERGKHFDPLCVDALVRIAGEKGWAFKASAS
>NC_012914.1|WP_012772449.1|528609_529599_+|L-glyceraldehyde-3-phosphate-reductase
MTYAADKSRFEDMKYFRVGKSGLKLPAVSLGLWHNFGGNDRLENGRAMIHRAFDLGITHFDLANNYGPPPGSAEETFGKVLKQDMAAYRDQMIISTKAGYYMWEGPYGDWGSRKYLVSSLDQSLKRMDLEYVDIFYHHRPDPETPLEETMAALDHIVRSGKALYVGLSNYSAEQTAQASAILKQLGTPCLIHQPSYSMFNRWIEDGLQDVLDQEGIGSIVFSPLAGGLLTNRYLDGIPTDSRAGGPSVFLNSNSITEEKLAKVRALNEIAQSRGQSLAQMALAWVLRGGRVTSALIGASRVEQIDDNVAVLSRLDFSDDELQAIENILA

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Crispr_ID: NC_012914_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012914_3

546577-547162

Orphan

Consensus_repeat	Method
AATAAGAGNGGAAAAACCGTGCTACAG	CRT

9 spacers

The CRISPR arrays of NC_012914_3

>merge|NC_012914|3|546577-547162|CRT
AATAAGAGGGAAAAACCGTGTTACAGAGGTGCGGACGCTCGAGCGCGCGGTTAAAGTAGCCCAATAAGACGGAAAAACCGTGCTACAGCCGGTGAACGGATGATCTGACTGGTGCAAGCGCGAAATAAGAGAGAAAAACCGTGCTACAGGGGTGCGGACGCTCGAGTGCAGGGTTAAAGCAGCCCAAATAAGAGGGAAAAACCGTGCTGCAGCCGGTGAACGGATGATCTGACTGGTGCAAGGCGCGAAATAAGAGAAAAAAACAGTGCTACAGAGTTGCGGACGCTCGAGCGCGGGGTTAAAGCAGCCCAATAAGACGGGAAGACCGTGCTACAGCCGGTGAACGGATGATCTGACTGGTGCAAGGCGCGACATAAGAGGGAAAAACCCGTGTTACAGTGGTGCGGACGCTCGAGCGCGGGGTTAAAGCAGCCCAAATAAGAGGGAAAAACCGTGCTGCAGCCGGTGAACGGATGATCTGACTGGTGCAAGGCGCGAAATAAGAGGAAAAAACCGTGTTACAGGGGTGCGGACGCTTGAGCGCGGGGTTAAAGCAGCCCAATAAGACGGAAAAACCGTGCTACAG

>NC_012914|3|1|546577-547162|CRT
AATAAGAGGGAAAAACCGTGTTACAG	AGGTGCGGACGCTCGAGCGCGCGGTTAAAGTAGCCC
AATAAGACGGAAAAACCGTGCTACAG	CCGGTGAACGGATGATCTGACTGGTGCAAGCGCGA
AATAAGAGAGAAAAACCGTGCTACAG	GGGTGCGGACGCTCGAGTGCAGGGTTAAAGCAGCCCA
AATAAGAGGGAAAAACCGTGCTGCAG	CCGGTGAACGGATGATCTGACTGGTGCAAGGCGCGA
AATAAGAGAAAAAAACAGTGCTACAG	AGTTGCGGACGCTCGAGCGCGGGGTTAAAGCAGCCC
AATAAGACGGGAAGACCGTGCTACAG	CCGGTGAACGGATGATCTGACTGGTGCAAGGCGCGAC
ATAAGAGGGAAAAACCCGTGTTACAG	TGGTGCGGACGCTCGAGCGCGGGGTTAAAGCAGCCCA
AATAAGAGGGAAAAACCGTGCTGCAG	CCGGTGAACGGATGATCTGACTGGTGCAAGGCGCGA
AATAAGAGGAAAAAACCGTGTTACAG	GGGTGCGGACGCTTGAGCGCGGGGTTAAAGCAGCCC
AATAAGACGGAAAAACCGTGCTACAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012914.1\|WP_041613840.1\|544448_545216_+\|sporulation-protein	unknown	unknown	gnl\|CDD\|369195
NC_012914.1\|WP_041613844.1\|548720_549884_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NC_012914.1\|WP_012772464.1\|547496_547793_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273952
NC_012914.1\|WP_012772459.1\|542006_542273_-\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|379763
NC_012914.1\|WP_012772457.1\|539694_540081_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_190276204.1\|543699_544197_-\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|234795
NC_012914.1\|WP_012772468.1\|549929_551126_-\|diglucosyl-diacylglycerol-synthase	unknown	unknown	gnl\|CDD\|237445
NC_012914.1\|WP_012772463.1\|545469_546543_+\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|377599
NC_012914.1\|WP_012772455.1\|538157_538361_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_012772469.1\|551303_552284_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381313
NC_012914.1\|WP_012772454.1\|537826_538045_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_012772473.1\|556807_557848_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_012914.1\|WP_083778003.1\|538454_539375_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_012914.1\|WP_041613842.1\|548054_548660_-\|VTT-domain-containing-protein	unknown	unknown	gnl\|CDD\|223475
NC_012914.1\|WP_012772471.1\|553700_554246_+\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_012772472.1\|554375_555383_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_012914.1\|WP_012772470.1\|552331_553600_-\|threonine-ammonia-lyase-IlvA	unknown	unknown	gnl\|CDD\|236318
NC_012914.1\|WP_012772460.1\|543040_543673_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240048
NC_012914.1\|WP_012772465.1\|547815_547959_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_012772458.1\|541377_541938_+\|superoxide-dismutase-family-protein	unknown	unknown	gnl\|CDD\|376292

Protein	Function_ID	Function_description	E-value
NC_012914.1\|WP_041613840.1\|544448_545216_+\|sporulation-protein	gnl\|CDD\|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	2.21541e-106
NC_012914.1\|WP_012772472.1\|554375_555383_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.07974e-119
NC_012914.1\|WP_012772464.1\|547496_547793_-\|hypothetical-protein	gnl\|CDD\|273952	TIGR02071, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0.00462545
NC_012914.1\|WP_012772459.1\|542006_542273_-\|phage-holin-family-protein	gnl\|CDD\|379763	pfam16079, Phage_holin_5_2, Phage holin family Hol44, in holin superfamily V. Phage_holin_V_2 is a family of small hydrophobic proteins with three transmembrane domains of the Hol44 family. These proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion. Full activity of the endolysin Lys44 from oenophage fOg44 requires sudden ion-nonspecific dissipation of the proton motive force, undertaken by the fOg44 holin during phage-infection.	3.07088e-15
NC_012914.1\|WP_190276204.1\|543699_544197_-\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|234795	PRK00567, mscL, large-conductance mechanosensitive channel protein MscL.	2.3951e-64
NC_012914.1\|WP_012772469.1\|551303_552284_+\|aldo/keto-reductase	gnl\|CDD\|381313	cd19087, AKR_AKR12A1_B1_C1, AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR). Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.	2.78911e-161
NC_012914.1\|WP_012772463.1\|545469_546543_+\|FUSC-family-protein	gnl\|CDD\|377599	pfam06081, ArAE_1, Aromatic acid exporter family member 1. This family consists of bacterial proteins with three transmembrane regions that are purported to be aromatic acid exporters.	2.75073e-35
NC_012914.1\|WP_041613844.1\|548720_549884_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.00494e-41
NC_012914.1\|WP_012772468.1\|549929_551126_-\|diglucosyl-diacylglycerol-synthase	gnl\|CDD\|237445	PRK13609, PRK13609, diacylglycerol glucosyltransferase; Provisional.	0
NC_012914.1\|WP_012772473.1\|556807_557848_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	6.40512e-115
NC_012914.1\|WP_083778003.1\|538454_539375_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.35664e-30
NC_012914.1\|WP_012772458.1\|541377_541938_+\|superoxide-dismutase-family-protein	gnl\|CDD\|376292	pfam00080, Sod_Cu, Copper/zinc superoxide dismutase (SODC). superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold.	7.27635e-47
NC_012914.1\|WP_012772470.1\|552331_553600_-\|threonine-ammonia-lyase-IlvA	gnl\|CDD\|236318	PRK08639, PRK08639, threonine dehydratase; Validated.	0
NC_012914.1\|WP_012772460.1\|543040_543673_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240048	cd04692, Nudix_Hydrolase_33, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	2.28691e-43
NC_012914.1\|WP_041613842.1\|548054_548660_-\|VTT-domain-containing-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	2.01435e-31

>NC_012914.1|WP_012772463.1|545469_546543_+|FUSC-family-protein
MTIGARVLKTGMAVALAIYLSGMFGFASPLITTVAAILTIQPSIYRSWQQVLDQFQTNLLGAAMALAAMKLFGQTPIAVGLVCILVILVSIRLKMETTIGVTLVTVVAIMEAHGQVTTVALERFLMVLAGMGAAFTVNVLVFPPRPRKQFTEQVHHAFSEMSLLLRTAISNEMKEQVYRKEKEKLHKRLRKLEDSYNLFEEERKILARTKISHARQLLVSKQMIKALQKGSDLLEVVEEHYFSVPKAGDWAARFDRQIEDLTKYHESIVLKIENKMKPNMSLEPGEEREARLVAELTDYVREDPDEHKRLIFVASALFEYAYHLRRLEKLVDHIQRPHGEAEERRSAEKADAAAVRE
>NC_012914.1|WP_041613840.1|544448_545216_+|sporulation-protein
MFNRLLASIGIGSAKIDTLLEKSQYVPGEEVRGVVNIRGGNAPQNIDTIQMSVMTEYIRESNDNRFRQHGEIGRYDVSTPFTLEAGETKEVPFSFRLPYQTPLTIGRAPVWVKTELEVRGGVDPGDNDRIDVLPTSAINTVFHALDLLGFRLRQAECEYSPRHGGEMPFVQEFEFVPTGQFRGQLDELEVMFYSSDRELELLLQVDRRARGLGGLFAEALDLDETFVRCRFTEEQLQAGPAVIARQLSELIARTI
>NC_012914.1|WP_190276204.1|543699_544197_-|large-conductance-mechanosensitive-channel-protein-MscL
MIQEFKEFAIKGNVIDLAVGVIIGGAFGKIVTSLVNDIIMPPIGRMLGGADFKDLFINLGSDKPLPAGVTTHDIHTLTDATKYGVAVIAYGQFINVLLDFFIVAVCIFLLVKGINILRRMKPEEVAAPAEPTEKECPYCLSQIPIKATRCKHCTSVLEEGTATSS
>NC_012914.1|WP_012772460.1|543040_543673_-|NUDIX-domain-containing-protein
MAEERFDIYDEQLNPLGTASRSETHALGYWHRSFHCWLTRREENRRFVRFQLRQAGKDTYPGYYDITAAGHLSAGETMQDAVREIEEELGVAARFEELIPLGEARKEMSGEVKGVPFIDREVSDVFALVCSLPLGDLKLQAEEVAAVFEADVELMIRLFEEELPELICEGVASTADGGLSKATRAVRAAEFVPREPSYYASIMRALRDCT
>NC_012914.1|WP_012772459.1|542006_542273_-|phage-holin-family-protein
MSWESITSLIDPRLVIVVAACWVIGYMLKQTPIVPDWTIVYAVTAVAILCACLILGFHVESVLQGILCGAFSVYGSQLVKQTFIKRGK
>NC_012914.1|WP_012772458.1|541377_541938_+|superoxide-dismutase-family-protein
MNKSMMLCSLGFLVASCGFSSAAMASQGHGHHTRSHVMEAKAAFIDTKGNQIGTVVLTEEKDGVHLKLEAKGLTPGVHGIHFHNVGKCEAPSFESAGSHLNPKNKQHGFDNPQGFHDGDLPNITVDKDGTVKADIISKNVTLDTEAPNSLLPAAGTALVIHEKADDYKTDPSGNSGSRIACGVIQH
>NC_012914.1|WP_012772457.1|539694_540081_-|hypothetical-protein
MSKEDDFADFRDQMKKLKNEKKSKNHREQDDVNDVIKRVKSEMLPVIKAFVDTDRSLEMQSNRSRAIYISYANSRIYGLWVSATSLDSINIDAVHDSFSTRIYSGSFIEKEIKTTVKNALLDWYRIII
>NC_012914.1|WP_083778003.1|538454_539375_+|protein-kinase
MKNTHSAPPWGNQTCAPPVCKGQGGIPIWWKQWINNWIDYPLGQGIVWGRTYRIEEFLGMGSYGQAYRCTDLRSGETVLLKRAKPSKRDTGRRLLRREADILQQLNHPQMPKRLDWVVHRREEALVMTYVEGVTAEQAALLEERTFTQLEALRIVEALLSPLKHMHEAGYVHRDVRIPNVVMNSKGIYLIDLGLACRIGEKNPDGREESVMPSGFADSWGAVKFRMRQPDRNSDLYGLGHLFLFLMYAGYTPQEGEKERSWEEELTLAPEIRGFVRGLLDSRWQTAAECERVLGKILEHYSSGNNE
>NC_012914.1|WP_012772455.1|538157_538361_-|hypothetical-protein
MIRHLLQRLLGSVTGKHYNKHGHHGHNGHNGHYSHSSSDYKKGNYYPPKQPPYGHSHYKKKYGSYSS
>NC_012914.1|WP_012772454.1|537826_538045_-|hypothetical-protein
MMKIITFKDRSVPVYYVNEQAASVEQLHHKLVEMEYNFDFRKKWKRISKVEVVRDVAIFQYNDGTKLYLEVS
>NC_012914.1|WP_012772464.1|547496_547793_-|hypothetical-protein
MSEQEQQHNQMEPMTGEHVEVSGVYKNDIGRVEKLERGEVFPADPQNGNTEWELVELDFDNHHEGRTDPRLIAKDDDDDPEAHMQHPRRHKGSNKTDS
>NC_012914.1|WP_012772465.1|547815_547959_-|hypothetical-protein
MSGEWPSHKQVEASKAQSLADRTGKGKEQASQKQSEADAAAVPKHGL
>NC_012914.1|WP_041613842.1|548054_548660_-|VTT-domain-containing-protein
MESMNNLYVQMKSLDLEHLQRTLESYSQFGILPGILLPLLESFLPFLPLIVIVAANANIFGLWLGFLLSWIGVSIGAICVFLISRKLGKNVKSRIERRFPKTERFFRWVDQKGFTPLFLLACFPFSPSSIINIVSGFSKISLRTFVLATVLGKGVMILSISLISFNIGSFREEPWRIFVTCAVIIVMWFGGKKIESRYHVN
>NC_012914.1|WP_041613844.1|548720_549884_-|MFS-transporter
MRFGAEMRLISVILFLVEFVRGAVLISLLPIYGTKVLGLSLDVIGIAITAHYLTDTLLKMVIGYLLDRFSIRFVVRTGLLISLAGVFLIQFANVAWLFILAAALYGIGMSPIWIVCLTKVSDDNRASQMGFLYTVWLTGLGAGPIVCNILLDYYVNGTYFLLLILSIFAAFLAFFMNSAKAGGQQIQAIPLKRQLVALMERIKAMRMLLPGMILQTAGASMLVPVLPSFAESELGFAGAQYSLLLSAGGVCAAAGLIPMGRLSDKLGGKKWFLIFGFAIFAAGLYMLAWRLPFWYCLVIVVILGLSYAAILPAWNALLAAYVPPKQEGLGWGLLSTVEGLGGMVGPLAGGILAASFGSRTVIWVSAALFGLIALLYVLIPATKMNGK
>NC_012914.1|WP_012772468.1|549929_551126_-|diglucosyl-diacylglycerol-synthase
MVRANNGYQPKVLILYASYGEGHLQAAKAIRDALEEAGNNRTVMVDLMAESHPWLNEMTRRVYLKSYTHIPHLYGWVYDVTRPMKHNSLFGGFLHSFGRDKIKKLLQKEQPDAVIHTFPFFALPALHRRRLSKTIHPGASIPTYTVITDFDLHRRWVHPGIGRYFVATDDLKQELGSLGIHPGRVSVTGIPLGRGFQSSLTPSFELFEKYGLHPEQPVILLMPGAQGVMPDCDELCRLLLEQHPHAQIALVCGRNNLLRSSIADQFRYHPSADRLHLFGFVDQVHELMSLATCLVSKPGGVTLAEAIWAGLPLFLYRPVPGQEKKNARYLQSKGAATISYDPEELAAAIMKLIRNPEQLQRCRLAVQRLRTEDAAADSIAHHILQECGWNAKFGQRYS
>NC_012914.1|WP_012772469.1|551303_552284_+|aldo/keto-reductase
MKYTYLGQSGLRVSRLCLGTMNFGVDTDEKEAFRIMDAALDAGINFFDTANIYGWGENSGRTEEIMGRWFAKGGGRREKTVLATKVYGDMHDPYDGPNREAGLSAYKIRRHLEGSLRRLQTDHIELYQMHHVDRNVNWNELWGAFETAVHQGKIGYVGSSNFAGWDIAVAQGEAKARGALGLVSEQHKYNLLCRLPELEVLPASKALGLGVIPWSPLDGGMLSGSHRHGGAGRRSGERNERFAQVKPQLDAYGALCDELGAPEDLVSLAWLLANPAVTAPIIGVRTLEQFERSLRAVELTLDESTLKRIDEIFPGPGGDAPKAYAW
>NC_012914.1|WP_012772470.1|552331_553600_-|threonine-ammonia-lyase-IlvA
MEFQSSYSSKIGLEDIVHAQMHLKDVITRTPLQYNRVLSERYGCNVYLKREDLQIVRSFKIRGAYHLMRSLPPERLAAGVVCASAGNHAQGVAYSCQALGVQGKIYMPSTTPRQKVNQVSFFGGDFVEVILTGDTFDDAYAEAIAESKRSGMAFIHPFDDPKIIAGNGTVGQELMEAAETVPDYVLASVGGGGLVAGIASYVKTVSPQTKVIGVEPEGAPSLRVSLDAGEVTPLEHIDKFVDGAAVKRIGDLTFSICRELLDDVRTIPEGKICTTLLDLYNENAIVAEPAGALPIAALDALRDEIAGKTVVCVISGGNNDVDRMQEIKERSLIYEGLKHYFMLSFPQRAGALREFLDDVLGPNDDITRFEYTKKHNKDNGPALVGIELKQREDYAALIGRMQKKGFQFVELNKDPVLFNLLI
>NC_012914.1|WP_012772471.1|553700_554246_+|hypothetical-protein
MFRWLKWLAIIVVLLAAIAAGGGLWLKSYVAPEEKLDLSYDPVSIKDKAVEMVANLKPEIVLSEADVNNLIKSQLQSSPASLPPDMTLDGARFEVNGDRLIAHLNMTYHDILPVGMLATYKMTWQAPNLTFEPLSLTVKNYDLGKDRLDRIVVPIELPSLISIGNMEFQQDQIVIKLRLQL
>NC_012914.1|WP_012772472.1|554375_555383_+|LacI-family-DNA-binding-transcriptional-regulator
MDKKIVDVAKRAGVSAATVSRVLNESSLVSEKTKIKVLKAIEEMDYHPNAAAKHLRSQRTMTLGIIVPDINVSYFSEIIKGIENKAYAHKYKVLICDSDNQIEKEMEYLGLLPDKTVDGMILVTPRVSDDIINEYVQKGYVIGVVGRAVVHDNILSCKTDNVKFSNEAVRHLVEQGHQQIAYIGGYSDSLENYERMEGYMKALKEGKIPFLPTLIDNGDFEETGGYQAFNRLLERNQSFTAVYCANDEMALGVYRACRERGIRIPEDMAIVGVDNNRITEYLLPSLSTVEQPKYEMGAHLTEKLIAQMNGNEQSAQKKYVIESKLIKRESSGFKR
>NC_012914.1|WP_012772473.1|556807_557848_+|LacI-family-DNA-binding-transcriptional-regulator
MNDSKIIDVANRAKVSVATVSRVLNRSELVSEKTKKRVLEAIQEMNYTPNAMAKNLRSKKTMKIGVVVADIEVSYFAEIIKGIENMANSLDYNVIICDAQNKKQKELEYVSLLQNRTVDAMIFVTPEMMSKELIALVEDGYSVGVIGRNIDHEQIPCAFTDNVKIARDVVNHLIGQGHEKIAFLSGYADAIDSYERLEGYMKALRDAGMPFVPDLIDNGDFNEDGGYLSFMRLREKNDDFTAIFTANDEMALGVYKACKQLSIQVPHQLAIVGVDNIRLTKYIVPRLSTVDQPKYTMGALLTEKLIDQMNNNEFKDKRTFKVESKLLIRESSMFDRNPVKSSEASQ

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Crispr_ID: NC_012914_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012914_4

715187-715261

Orphan

Consensus_repeat	Method
CTAACGAAACTAGGTAACGCTATTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012914_4

>merge|NC_012914|4|715187-715261|CRISPRCasFinder
CTAACGAAACTAGGTAACGCTATTCGGTTGATCTGGCGGGATTTTTGATTCTAACGAAACTAGGTGACGCTATTC

>NC_012914|4|3|715187-715261|CRISPRCasFinder
CTAACGAAACTAGGTAACGCTATTC	GGTTGATCTGGCGGGATTTTTGATT
CTAACGAAACTAGGTGACGCTATTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012914.1\|WP_012772616.1\|718469_719390_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NC_012914.1\|WP_012772604.1\|706993_709090_-\|CocE/NonD-family-hydrolase	unknown	unknown	gnl\|CDD\|225487
NC_012914.1\|WP_012772610.1\|713957_714581_+\|ferric-reductase-like-transmembrane-domain-containing-protein	unknown	unknown	gnl\|CDD\|226582
NC_012914.1\|WP_012772609.1\|713028_713961_+\|FAD:protein-FMN-transferase	unknown	unknown	gnl\|CDD\|376782
NC_012914.1\|WP_012772603.1\|706171_706936_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|183719
NC_012914.1\|WP_012772605.1\|709102_710263_-\|membrane-dipeptidase	unknown	unknown	gnl\|CDD\|366534
NC_012914.1\|WP_012772620.1\|725217_726582_-\|TrkH-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223246
NC_012914.1\|WP_012772612.1\|715383_716265_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_012914.1\|WP_012772608.1\|712721_713012_+\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_012772606.1\|710275_711253_-\|ornithine-cyclodeaminase-family-protein	unknown	unknown	gnl\|CDD\|225280
NC_012914.1\|WP_190276205.1\|720111_723099_-\|glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|271156
NC_012914.1\|WP_012772615.1\|718124_718370_+\|H-type-small-acid-soluble-spore-protein	unknown	unknown	gnl\|CDD\|377962
NC_012914.1\|WP_012772617.1\|719358_719904_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|379122
NC_012914.1\|WP_012772614.1\|717741_718053_+\|DUF5519-family-protein	unknown	unknown	gnl\|CDD\|375228
NC_012914.1\|WP_190276177.1\|711391_712438_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_012914.1\|WP_012772613.1\|716373_717651_+\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|376374
NC_012914.1\|WP_012772619.1\|724348_725125_-\|glutamate-racemase	unknown	unknown	gnl\|CDD\|234851
NC_012914.1\|WP_012772611.1\|714711_714999_+\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_150106419.1\|726787_727924_+\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NC_012914.1\|WP_012772602.1\|705237_705999_-\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|376615

Protein	Function_ID	Function_description	E-value
NC_012914.1\|WP_012772616.1\|718469_719390_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	5.33659e-16
NC_012914.1\|WP_012772604.1\|706993_709090_-\|CocE/NonD-family-hydrolase	gnl\|CDD\|225487	COG2936, COG2936, Predicted acyl esterases [General function prediction only].	4.53151e-113
NC_012914.1\|WP_012772610.1\|713957_714581_+\|ferric-reductase-like-transmembrane-domain-containing-protein	gnl\|CDD\|226582	COG4097, COG4097, Predicted ferric reductase [Inorganic ion transport and metabolism].	2.18113e-05
NC_012914.1\|WP_012772609.1\|713028_713961_+\|FAD:protein-FMN-transferase	gnl\|CDD\|376782	pfam02424, ApbE, ApbE family. This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis. It acts as an FAD:protein FMN-transferase, catalyzing the attachment of an FMN residue to a threonine residue of a protein via a phosphoester bond in such bacterial flavoproteins.	3.07979e-46
NC_012914.1\|WP_012772603.1\|706171_706936_+\|SDR-family-oxidoreductase	gnl\|CDD\|183719	PRK12747, PRK12747, short chain dehydrogenase; Provisional.	2.63181e-96
NC_012914.1\|WP_012772605.1\|709102_710263_-\|membrane-dipeptidase	gnl\|CDD\|366534	pfam01244, Peptidase_M19, Membrane dipeptidase (Peptidase family M19).	2.58427e-84
NC_012914.1\|WP_012772612.1\|715383_716265_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.79784e-56
NC_012914.1\|WP_150106419.1\|726787_727924_+\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	5.01895e-87
NC_012914.1\|WP_012772606.1\|710275_711253_-\|ornithine-cyclodeaminase-family-protein	gnl\|CDD\|225280	COG2423, COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism].	5.04902e-93
NC_012914.1\|WP_190276205.1\|720111_723099_-\|glycosyl-hydrolase	gnl\|CDD\|271156	cd14490, CBM6-CBM35-CBM36_like_1, uncharacterized members of the carbohydrate binding module 6 (CBM6) and CBM35_like superfamily. Carbohydrate binding module family 6 (CBM6, family 6 CBM), also known as cellulose binding domain family VI (CBD VI), and related CBMs (CBM35 and CBM36). These are non-catalytic carbohydrate binding domains found in a range of enzymes that display activities against a diverse range of carbohydrate targets, including mannan, xylan, beta-glucans, cellulose, agarose, and arabinans. These domains facilitate the strong binding of the appended catalytic modules to their dedicated, insoluble substrates. Many of these CBMs are associated with glycoside hydrolase (GH) domains. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold. CBM36s are calcium-dependent xylan binding domains. CBM35s display conserved specificity through extensive sequence similarity, but divergent function through their appended catalytic modules.	3.58088e-49
NC_012914.1\|WP_012772615.1\|718124_718370_+\|H-type-small-acid-soluble-spore-protein	gnl\|CDD\|377962	pfam08141, SspH, Small acid-soluble spore protein H family. This family consists of the small acid-soluble spore proteins (SASP) of the H type (sspH). SspH are unique to spores of Bacillus subtilis and are expressed only in the forespore compartment during sporulation of this organism. The sspH genes are monocistronic and are recognized by the forespore-specific sigma factor for RNA polymerase - sigma-G. The specific role of this protein is unclear but is thought to play a role in sporulation under conditions different from that of the common laboratory tests of spore properties.	2.22811e-25
NC_012914.1\|WP_012772617.1\|719358_719904_-\|HD-domain-containing-protein	gnl\|CDD\|379122	pfam13328, HD_4, HD domain. HD domains are metal dependent phosphohydrolases.	1.96483e-31
NC_012914.1\|WP_012772614.1\|717741_718053_+\|DUF5519-family-protein	gnl\|CDD\|375228	pfam17648, DUF5519, Family of unknown function (DUF5519). This is a family of unknown function.	5.64271e-32
NC_012914.1\|WP_190276177.1\|711391_712438_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.17592e-52
NC_012914.1\|WP_012772613.1\|716373_717651_+\|adenylosuccinate-synthase	gnl\|CDD\|376374	pfam00709, Adenylsucc_synt, Adenylosuccinate synthetase.	0
NC_012914.1\|WP_012772619.1\|724348_725125_-\|glutamate-racemase	gnl\|CDD\|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	3.89828e-90
NC_012914.1\|WP_012772620.1\|725217_726582_-\|TrkH-family-potassium-uptake-protein	gnl\|CDD\|223246	COG0168, TrkG, Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	1.13082e-77
NC_012914.1\|WP_012772602.1\|705237_705999_-\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|376615	pfam01790, LGT, Prolipoprotein diacylglyceryl transferase.	8.00204e-23

>NC_012914.1|WP_012772611.1|714711_714999_+|hypothetical-protein
MLGSLTLWMEVALWVVLGSMGANLLVDLFKMVTGGKFSMDFVLGYLKDLLYYVMPLLLLAGLSLMDVTGWVVLVGYYLGALAVLLKYLMDLKGKL
>NC_012914.1|WP_012772610.1|713957_714581_+|ferric-reductase-like-transmembrane-domain-containing-protein
MNQLLDALSVWTTTRASGITSYLFLFLSTIAGISMGSRLIKNKAKLMVLTIHQSAGWFGFLFGMMHGAVLLFDQYVGYSLSGLLIPFTAESHPVLTGMGTLSFYMCFIVILSSDMMKKLGKKAWKMTHMLAFPGYFLALLHGLLIGSDSSYPWAQAMYGATGAIVVALTVYRVWTVKKDKRDAPKSGRVTYPHANPIIIEPGDYKVR
>NC_012914.1|WP_012772609.1|713028_713961_+|FAD:protein-FMN-transferase
MTLHRFRAMNSQFFTKGLHDGAQAMAESWITVVEEKLSRFNPRSELSQMNQSAGQPFSASTLLYEVMAEANRYYEATDGLFNPYMGQLIHELGYSGTFESLAGRSAHVEPVLTAKPFDCEQPLILDSGTRALTLDLKLAVDLGGFAKGWSAHQLSLMIQHAGVRSGAIGAGGDITLWGVPDEGWSVCIGDPWEASRDLMTLQVRYPAGIATSNTVRRQWKDSAGQSRHHIIHPRTGAPVDSDLAQVTLFAPNLMDAEVYAKCVLLLGREQGFEWLAGNHPACAAVGVLHDGSIRTVGAIGQYVGERGLYA
>NC_012914.1|WP_012772608.1|712721_713012_+|hypothetical-protein
MANSKWVKWVVGLSSVALFTGMVGVINHSSANPATAPVSSDVLNSSPSDGGIQGNDGTGSYEQRPFGRGRGMGQDFGSGTDSGTSSGDEGMRTHAS
>NC_012914.1|WP_190276177.1|711391_712438_-|GGDEF-domain-containing-protein
MPVRIFFLAKCLQSCSWFLVVLRGDIPDFLTISVANSLMFVGASLETISMLRLRNEWRTRYKIMYKLAIPLSIAGFHLIMLIHNEEEARIAYCSAALAIILAPMYRLIKGPSPLMKVIGYIYLFVIAANLVRGTTALFTDIPASFYTPGIYQLLYLVTIYILTILGIMGFMLLWKEKTNQELLHYASYDDLTGALNRRTFMTSAKRYLNHYAKKGEAVSYLLFDIDSFKDINDKYGHHIGDLVLQDVTKRIRHYLDKDDLFVRYGGDEFGILLPGKGEQESSALAERIKIMLQSAPTTLPVSYTISMGVLTVVPDQHTHMESMYTKCDQALYTAKRNGRNNIYRSQFG
>NC_012914.1|WP_012772606.1|710275_711253_-|ornithine-cyclodeaminase-family-protein
MLVIDRNVVSELLTMEACIPLMENVLSDLSAGQAEQQLRSVVPVRQGGLMGLMPAYLASQETVGAKLISVFPHNHNRGLPSHQGVIALFDAENGAMNAIVDGRNVTAIRTAAVSAAATKLLAREDSRVLALIGTGEQARTHLEALLLVRPIELVRIWSPNLEHATKFKNEMDAKYAELTIEISATARLAVAEADIICTLTSSTTPVLQGEWIPEGAHINAVGACRAPDRELATSIVRQAKLYVDRYESAVNEAGDYLIPLQEGAIGSDHIIGEIGEVLLGRAPGRASDKDVTLFKSLGLAVEDLAVAAYLHKQAKLQGKGITIAI
>NC_012914.1|WP_012772605.1|709102_710263_-|membrane-dipeptidase
MKNHQGLYDFHLTPEQEKRALDIHERSIVIDLLFQGPLSPRVVPAEVSAQIKEECEALKDNPMAYSALPAKRLRQMSVSGELPAFKEEWYRSGITAGNREVDLSSPEAIITSMGEMQEQFDRFGWLVKALSADDIREAKRKGLKAGIVTSQDPGGLGKNLDLLEALHGFGLRVLQLTYNNQNSIASGCMELANGGVSNFGVTFISRMNELGIVVDTSHCGEQTTLDACRLSTQPVIASHTGVEAIYPHRRCKSDEELRAIAATGGVIGVFAMPWFVHGDPQATTIDHVLDHIDYIVRLVGVDHVGIGTDWPMSDLDWSLVYFKEHIAPKLGFAKGDGPSTELVAGLEQYGLFINFTRGLVARGYSDEEVSKIIGGNWLRIFEQVWG
>NC_012914.1|WP_012772604.1|706993_709090_-|CocE/NonD-family-hydrolase
MTIYNFYCAGVYEGKIRFTEDKVMHARVDRRRRTQMREHVLDPQAKYILPLQQLRENLPVYSQTEWSGERVVTANGETYHRHLTYTDEQGRTSQVWAKRNDTAVDIVTLEGAVIAFLCPNRYGMEIIVREGLEKLTPLVVYDDPGLSKPEYGVNDLGTFLVPMRDGLKLATDVYLPEGIQPGAKLPTILVRTCYDRAGKKEHFLRWANKGYAVVNQDVRGRADSEGELVPFYYEREDGSDTIDWIISQEWSNGDVGMWGASYLGYVVMAASTSGHPNLKAVVNEVNVGSPFVDTVRRGGTVCSWPLLSWTLAQSVGTRTDFEIFGGITVDPAKAVEARPIREIPQQMIGRDSGPWDFWSQHPEYDEYWKNCTHSERADQIKAPMFVISGWYDGDSPGVSETWRLLTEHDVPNRKIWLGPWEHGPNRARDLEGTAFGEDAVVYDYDVNVLRWFDHFLKGAANGINEEPRARYYVVGENKWRTSTDWTPVEASVTPFYLGGGGRANSAFGDGKLTLRQPQDSTPDVYVYNPGDPVVDSGERIPENRRTIELRQDVLCYTGDKLEQPLKIAGELSAVLYAASSAVDTDWVVALSDVDEAGNSILLSSYIVRAKYRHGYDKPELLIPGKVERFDIFLPNIAHQFPAGHRIRFSITSSSKFVAFPNSNTGLNPYDDPEPIPATQTIYHSGQYPSHVLLPVLGE
>NC_012914.1|WP_012772603.1|706171_706936_+|SDR-family-oxidoreductase
MSRLSGKIALVTGASKGIGRAIALRLAEEGAIVAVHYGSNHDAAADVVRQIGQMGGEAFAIGQELGTLASAVKLFEGLDLALEQRTGEKYIDILVNNAGVGLVTAIEETTEAAFDHVMNTNVKGPFFLVQQALSRIRDGGRMINLSSAVTRISLPGVAAYSMSKGAVNTLTLSLSTQLAPRGITVNALQPGFVATDMNKAMLQDESGYQFGAGYSSFGRWGEPSDIADVAAFLASSDSRWITGQCIDVSGGSHL
>NC_012914.1|WP_012772602.1|705237_705999_-|prolipoprotein-diacylglyceryl-transferase
MTFPVWIDLGFVKLHPHAVFETLAYFIGFRVYLYTRSKDKIPIVQGMWVIVGAIMGAAVGSKLLYWFEDPSLTLESWNSYTYLMEGKTIVGGLLGGLIGVEWTKKRIGYSRSTGDDMALPLIVGMVIGRIGCFLTGLDDHTYGVATSWITGIDFGDGVLRHPTQLYEIAFLLLLGAFLFHWKRKGSLPDGAVFQLFMTGYLLFRFVIDFIKPTPHFYLGLNNIQLACIAGLIYYAVLLSKWLVRPQRSHRKEL
>NC_012914.1|WP_012772612.1|715383_716265_-|LysR-family-transcriptional-regulator
MEVNLEWYRVFYWIAKTGSLSKAAEQLHITQPAVSHTVKQLESTLGGQLFFRTPRGVTLTKEGTVLLQYIEQAFQSVQIGEKAIAEMNNLHTGEIAIGASDTLCKHYLLPYLEQFHEQHPGVRVRVTNRTTPETLALLKEGKIDFGIVSLPVSDKQVAISESTLLQDCFVGGKGYQSLSGGPPLTLEQLNAYPLLLLEKGSSTRRYLDDYAASHGSTFTPEFELGSVDLLVQFAKSGFGLAFVIRNYVAEELQRGELVEIPLTETFPGRPIGIATLRGIPMSSATKSFLALLP
>NC_012914.1|WP_012772613.1|716373_717651_+|adenylosuccinate-synthase
MTVTAIVGANWGDEGKGKMTDVWAAQSSYVVRFQGGSNAGHTIINDFGKFALHMLPSGVFNPNVTNVIGPGTALDIGVLLDELKALSARGVPTPKIIISDRAQIVLPVHRLFDELEEERLGNNSFGSTRRGIAPFYADKYTKLGIQAADLLEPARLLKRVERLLEAKNVLLQHLYGQPPMQAEDLMPELLEQAKLLAPYIGDTTSLLQKAYIHGEPILLEGQLGALRDPDHGIYPYTTSSSTLAGFASVGAGLPPYAIQQVVAVTKAYSSCVGAGPFVSELQGAQAEELRKRGGDAGEYGVTTGRPRRVGWFDAVATRYGCRLQGATSVVLTNLDVLGYLDEIPVCVGYETADGVIDDFPITSKLEGAKPVYKSMPGWKSTISEIRQFDDLPLAAKQYVEFVESEIGVPIATISVGPKRDQVITR
>NC_012914.1|WP_012772614.1|717741_718053_+|DUF5519-family-protein
MGSKAVLEELLLSWPGVTTGPHRFGGIEFAVNGKEIGHLHGGRLVDLLLPKAKRDEAVTTGKAKSHHILPESGWVSVYLNTEDDLAHAIELLRFNYERFAQVP
>NC_012914.1|WP_012772615.1|718124_718370_+|H-type-small-acid-soluble-spore-protein
MDINRAKEIAASPVMEDVKYNEMQVYIQHVDDARGTARIYPLSNPEQELDVPVRSLVEQSSTMAMEVEQVACRVSDGETEQ
>NC_012914.1|WP_012772616.1|718469_719390_+|DMT-family-transporter
MKQQAQLKSSLLLILAAFIWGFAFVAQRQGMEHTGPFTFNAVRFVLGAISLLPLIWIMDRKSGQTKAQLRGSFRSASKYGVCTGLILFVGASLQQIGLMYTTAGKAAFVTGLYIVIVPFFGLFLKQRFGVNSGIGAVLAVIGLYLLCMTNDLTLGKGDLYELVGALFWSVHILMIDRFSRKTDGLKLSLAQILTCSVLSFIAAFSTEKVELSGLSDAMIPLLYGGICSVGIAYTLQIVGQKNAHPAQAAIILSLETVFAAIGGYLLLDEVLGVRAGIGCMFMLVGMIVPQLPPLWRVNRKNRSLLE
>NC_012914.1|WP_012772617.1|719358_719904_-|HD-domain-containing-protein
MNVMDVAIEFAATAHQAQYRKGTGIPYISHPFGVAMLLSSYNYSEEVIIAALLHDVLEDTDTTEQQLTDRFGPEITFIVKGCSEPDKSLSWEERKTHTIESLPSSSLEIRLVACADKLHNLRSMKREFETSGPSFWSRFKRGEKEQAWYYKSLAEAFAKPEDSSSHPLFALFIQEVNDFYG
>NC_012914.1|WP_190276205.1|720111_723099_-|glycosyl-hydrolase
MDQISVAASATPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTATPTPTPTPTPTPTPPASGNVALGKTITASSSTFTYVAANGNDGSTSTYWEGSGNPSQLTVDLGANHDLTSVVVKLNPATEWSTRTQTIQVLGANQSTTTFSNLVSAQSYTFNPSSGNTVTIPVTATVSKVQLNITANSGASGGQVAEFEIYGTPAPNPDLTITGMTWTPANPVETDAITLNATVKNIGNASSPASSVNFYLGNELVGTAPVAALAANATATVSVNAGARNAGNYPVSAKVDESNTVIEQNNNNNSYSNSAGITVAAVQSSDLIVSTTWNPSNPSAGNTVTFTTNLKNQGNIASAAGAHPISVALKNASGATVQTWNGSYTGSLAAGQSVNVTMGTWTAVNGSYSVTTTVAADGSEVSTKQTNNSNTVSLYSGRGANMPFTIIEAESASNATNGTKLAPNFKPGDYAGEASGRSSVYLDAAGEYVEFTLTSPANAFVLRNAVAENTTGTVSIYADGVSKGKFNVSSKFSYLYATPSTLGRLGYDNAPGAGLTAYWLYEDAQLMLDQVYPAGTKIKIQKDAGDVSWIYVDLLETENVAPPQANPDPTKYVAVSASKSIDQALTEFRQDNTKKGIYIPAGEWTINSKIFLYGRATEIVGAGPWYTKLVAPQSQSNTDVGFNISAAANGSTIRDLSAWGNYINRVDGPGKFIDGNGMQNVTVQNIWVEHFVCLYWGVNSSYNTFKNNRIKNTFADGINMTNGSSYNVIDNNYARGTGDDSFALFSATDSGGSYNVGNKYTNLTATNVRRAAAFAVYGGSDNLFQNLYGADTLTYPGITISSYSFGYNTLGFGDQDTVIDGATLDRTGGDFWTSVGADDKINDYQNFGAIWIYGGDRAIKNILIKNVDINNPVYFGLMFQSMTPNNMVMQNIRVENVNINNPSRYGIKLVLRAEQGQGPAYGGASFTNVKVNNPGISAIYGEAQSPNFTVTRVSGNNW
>NC_012914.1|WP_012772619.1|724348_725125_-|glutamate-racemase
MTIGIFDSGLGGLTVLAEALKRLPAENYIYMADTKHVPYGTKSEEEVRDFVLQTVEQMVAEGIDALVVACNTATSIAINELRERYSFPIIGMEPAVKPAVEMNRATGKKVLVWATPLTLRMPKYYALVSRVDEEGIVDSLPMPELVQYCEALQFDKDVLKDYFLAKLAPYDLNEYGILVLGCTHFPFYTSILRNVLPPHIQIVNGNLGTIRRLTAMLSRYGIGTGRGSGQVRFMCTGGEAAYIEKMRSALSYLKEQDL
>NC_012914.1|WP_012772620.1|725217_726582_-|TrkH-family-potassium-uptake-protein
MFKTSREWVSRRSPAQVITGYYILAVLISILLFSIPAVRRPGIEVSFFDTVFTAVSVVSDTGLSVFNVAETYSVFGYFVIMLVLQFGGIGIMAMSTFFWLLIGRKIGLRERRLIMVDNNQFALSGLVQLVKEILRITLLTELLGAVIFGLRFLRYFPTWQEAFLQGLFASVSATTNAGMDITGQSLIPFKDDYFVQLVTILLIIFGAIGFPVLIELKAFLSRNKLDLNHPFRFSLFTKLTTFTYFALLGIGTICILLFESQHYFKGLTWHESFFYAFFQAATTRSAGLTTMDITHLTLPTLLLMCVYMFIGGSPNSVGGGIRTTTFALNMLFIFHFARGRRDYKVFKRELHIDDILKSLAISMMAIVMCSLSVVAISFSDKQHQLVAIILEVCSAFGTVGLSTGITPDLSIFAKCILMLLMFIGRIGLTSFLYIIGGQQTTSKYRYPVERVMTG
>NC_012914.1|WP_150106419.1|726787_727924_+|tyrosine-protein-phosphatase
MKMKVSKVYAATVLAASLALGAVAAPAASFAAPAAVSQKKVQGVFTQASVERTSDGKLKIHWNSNADLGAAKILWSTSPDNIATNGKQLKRINASYNGYVTTDPKPGSRLYFYIKTSSGATVTVAERKVNLQGAYNFRDLGGYKTTDGKTVKWGKLFRGEELGHLTDADIKTIQEMGIKSNVDYRTDAEVNALPDPVIPGIANIRTDAGNAGSAADLNSMIASGLMKDEASAVAMMAGFNKQMVDSPKFYIQLMELLNDPDNIGLVQHCTAGKDRTGLGSAIILLALGVDEKTVMDDYLLSNVYRAEANKKAIEAVKAQVKDENVVAAITAMMGVQKEFLQAAIDEMKAKYGSIDNFLEKGLGITKQERAKLKAMYTE

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Crispr_ID: NC_012914_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012914_5

2107799-2107912

Orphan

Consensus_repeat	Method
CGTCACACCCTCGTCCGCTCGTTCCGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012914_5

>merge|NC_012914|5|2107799-2107912|CRISPRCasFinder
CGTCACACCCTCGTCCGCTCGTTCCGCGTATTTGCGTGCGAATCGTCACACCCTCGTCCGCTCGTTCCGCGACTTTGCGTGCGAATCGTCACACCCTCGTCCGCTCGTTCCGCG

>NC_012914|5|4|2107799-2107912|CRISPRCasFinder
CGTCACACCCTCGTCCGCTCGTTCCGCG	TATTTGCGTGCGAATCGTCACACCCTCGTCCGCTCGTTCCGCGACTTTGCGTGCGAAT
CGTCACACCCTCGTCCGCTCGTTCCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012914.1\|WP_015843387.1\|2104883_2105414_+\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_015843385.1\|2102069_2102969_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012914.1\|WP_015843384.1\|2101136_2102051_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_012914.1\|WP_015843381.1\|2097087_2097927_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_012914.1\|WP_015843382.1\|2098145_2099099_+\|glycoside-hydrolase-family-43-protein	unknown	unknown	gnl\|CDD\|350141
NC_012914.1\|WP_015843391.1\|2110708_2111278_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_012914.1\|WP_015843393.1\|2112279_2114139_+\|assimilatory-sulfite-reductase-(NADPH)-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|273882
NC_012914.1\|WP_041613387.1\|2119396_2120206_+\|ATP-dependent-sacrificial-sulfur-transferase-LarE	unknown	unknown	gnl\|CDD\|238948
NC_012914.1\|WP_015843379.1\|2094452_2095937_+\|alpha-L-fucosidase	unknown	unknown	gnl\|CDD\|226195
NC_012914.1\|WP_015843386.1\|2102991_2104743_+\|beta-galactosidase	unknown	unknown	gnl\|CDD\|236657
NC_012914.1\|WP_015843394.1\|2114210_2115935_+\|assimilatory-sulfite-reductase-(NADPH)-hemoprotein-subunit	unknown	unknown	gnl\|CDD\|237402
NC_012914.1\|WP_015843388.1\|2105680_2107729_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373013
NC_012914.1\|WP_190276185.1\|2095887_2096973_+\|peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|376360
NC_012914.1\|WP_015843396.1\|2117318_2118587_+\|DUF2088-domain-containing-protein	unknown	unknown	gnl\|CDD\|370728
NC_012914.1\|WP_015843395.1\|2115980_2117144_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NC_012914.1\|WP_150106635.1\|2099303_2101040_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270302
NC_012914.1\|WP_015843389.1\|2108626_2109277_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_015843397.1\|2118614_2119388_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236216
NC_012914.1\|WP_015843392.1\|2111274_2112138_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|162743
NC_012914.1\|WP_150106636.1\|2109588_2110575_+\|cell-wall-hydrolase	unknown	unknown	gnl\|CDD\|377847

Protein	Function_ID	Function_description	E-value
NC_012914.1\|WP_015843385.1\|2102069_2102969_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.89188e-53
NC_012914.1\|WP_015843391.1\|2110708_2111278_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	7.04672e-06
NC_012914.1\|WP_015843384.1\|2101136_2102051_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	5.54483e-115
NC_012914.1\|WP_015843381.1\|2097087_2097927_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	6.15509e-25
NC_012914.1\|WP_015843382.1\|2098145_2099099_+\|glycoside-hydrolase-family-43-protein	gnl\|CDD\|350141	cd18820, GH43_LbAraf43-like, Glycosyl hydrolase family 43 proteins similar to Lactobacillus brevis alpha-L-arabinofuranosidase LbAraf43 and Geobacillus thermoleovorans GbtXyl43B. This uncharacterized glycosyl hydrolase family 43 (GH43) subgroup belongs to a subgroup which includes enzymes with beta-xylosidase (EC 3.2.1.37), alpha-L-arabinofuranosidase (EC 3.2.1.55) and possibly bifunctional xylosidase/arabinofuranosidase activities, similar to Lactobacillus brevis alpha-L-arabinofuranosidase LbAraf43 and Geobacillus thermoleovorans IT-08 beta-xylosidase / exo-xylanase (GbtXyl43B). It belongs to the glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) which includes family 43 (GH43) and 62 (GH62) families. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	1.26103e-128
NC_012914.1\|WP_015843396.1\|2117318_2118587_+\|DUF2088-domain-containing-protein	gnl\|CDD\|370728	pfam09861, DUF2088, Domain of unknown function (DUF2088). This domain, found in various hypothetical prokaryotic proteins, has no known function.	4.74547e-07
NC_012914.1\|WP_015843393.1\|2112279_2114139_+\|assimilatory-sulfite-reductase-(NADPH)-flavoprotein-subunit	gnl\|CDD\|273882	TIGR01931, Sulfite_reductase_flavoprotein_alpha-component, sulfite reductase [NADPH] flavoprotein, alpha-component. This model describes an NADPH-dependent sulfite reductase flavoprotein subunit. Most members of this family are found in Cys biosynthesis gene clusters. The closest homologs below the trusted cutoff are designated as subunits nitrate reductase.	0
NC_012914.1\|WP_041613387.1\|2119396_2120206_+\|ATP-dependent-sacrificial-sulfur-transferase-LarE	gnl\|CDD\|238948	cd01990, Alpha_ANH_like_I, This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily of proteins probably binds ATP. This domain is about 200 amino acids long with a strongly conserved motif SGGKD at the N terminus.	9.1915e-100
NC_012914.1\|WP_015843379.1\|2094452_2095937_+\|alpha-L-fucosidase	gnl\|CDD\|226195	COG3669, COG3669, Alpha-L-fucosidase [Carbohydrate transport and metabolism].	1.51331e-68
NC_012914.1\|WP_015843386.1\|2102991_2104743_+\|beta-galactosidase	gnl\|CDD\|236657	PRK10150, PRK10150, beta-D-glucuronidase; Provisional.	2.91073e-43
NC_012914.1\|WP_015843388.1\|2105680_2107729_+\|hypothetical-protein	gnl\|CDD\|373013	pfam14323, GxGYxYP_C, GxGYxYP putative glycoside hydrolase C-terminal domain. This family carries a characteristic sequence motif, GxGYxYP, and is a putative glycoside hydrolase. This domain is found in association with pfam16216. Associated families are sugar-processing domains.	3.15249e-61
NC_012914.1\|WP_190276185.1\|2095887_2096973_+\|peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|376360	pfam00639, Rotamase, PPIC-type PPIASE domain. Rotamases increase the rate of protein folding by catalyzing the interconversion of cis-proline and trans-proline.	9.72347e-06
NC_012914.1\|WP_015843395.1\|2115980_2117144_-\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.1819e-61
NC_012914.1\|WP_150106635.1\|2099303_2101040_+\|extracellular-solute-binding-protein	gnl\|CDD\|270302	cd13584, PBP2_AlgQ1_2, Periplasmic-binding component of alginate-specific ABC uptake system; contains the type 2 periplasmic binding fold. This group represents the periplasmic-binding component of high molecular weight (HMW) alginate uptake system found in gram-negative soil bacteria such as Sphingomonas sp. A1. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that includes alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	9.35071e-81
NC_012914.1\|WP_015843394.1\|2114210_2115935_+\|assimilatory-sulfite-reductase-(NADPH)-hemoprotein-subunit	gnl\|CDD\|237402	PRK13504, PRK13504, NADPH-dependent assimilatory sulfite reductase hemoprotein subunit.	0
NC_012914.1\|WP_015843397.1\|2118614_2119388_+\|SDR-family-oxidoreductase	gnl\|CDD\|236216	PRK08277, PRK08277, D-mannonate oxidoreductase; Provisional.	4.46245e-112
NC_012914.1\|WP_015843392.1\|2111274_2112138_+\|phosphotransferase	gnl\|CDD\|162743	TIGR02172, Fb_sc_TIGR02172, Fibrobacter succinogenes paralogous family TIGR02172. This model describes a paralogous family of five proteins, likely to be enzymes, in the rumen bacterium Fibrobacter succinogenes S85. Members show homology to proteins described by pfam01636, a phosphotransferase enzyme family associated with resistance to aminoglycoside antibiotics.	5.48809e-18
NC_012914.1\|WP_150106636.1\|2109588_2110575_+\|cell-wall-hydrolase	gnl\|CDD\|377847	pfam07486, Hydrolase_2, Cell Wall Hydrolase. These enzymes have been implicated in cell wall hydrolysis, most extensively in Bacillus subtilis. For instance Bacillus subtilis steB is expressed during sporulation as an inactive form and then deposited on the cell outer cortex. During germination the the enzyme is activated and hydrolyzes the cortex. A similar role is carried out by the partially redundant Bacillus subtilis CwlJ. It is not clear whether these enzymes are amidases or peptidases.	3.00776e-35

>NC_012914.1|WP_015843388.1|2105680_2107729_+|hypothetical-protein
MIRKLTAISLAIVSTLSFTAAGSYADPQPAAQGSTISWPDKQQLPTFKQPKQLEVADIYDAPGDVKLMLSTLQGIVNRKEPRIYLLESKEEGKYKWLNDLDVDYKVRDDYFDLLKKFQKEVKGIIVYDPNVPDSVNVATTLAGLRDGVAVSPELAAKLQAAPYNLKVIEDLQGKFKDRVDAYTWEYENLWKETSHRMLVGLSPEVSARPPANQPDTYKVVAQEKTEERDAKNRQVYDLDLSSFLAKPDVYVKFGDAFTQDGWGSAVHEITVKADGVEVAHFLPGTDAEKPFLYDPQSSQVSSGSGGHRFADGGNYFTYKFTPPAGTKALTMSVEMWNEYKVSATNDQPFSSLTKEPYGYLRDYAVANKAMVFWLDSNDPAEKELFEKILSDVKPGTPYLGWFSNDFQGEFSGVEVASNHGVYVLAADWFSNMTVFSGTKPEFSKPKAPKPVKLDNKIYVTYTFSEGDNLQYNQHRLRNLWDDPKRGQVPINWTSSPLLYDAAPAMLNYFYGTATANDQIIAGPSGAGYFYPAAWPEKALTDYLKNTKDYLKKTGMNIPYVLNRLNGENLPLSKANNAAYRDQYEVPGLFIGWDNFTKVDIVDGVPTSNIQGVGSVNDTKKALADAKAKWDGKSPLFVSLGILAWGMTPTDLANVTAELGPEYQVVLADQYFSLIRDANGLKK
>NC_012914.1|WP_015843387.1|2104883_2105414_+|hypothetical-protein
MKKLGMLFCVCLLLLYGCRSSDNGLANAQEKIEQSNLSFKIPKLDGYEVIYVQRVGPPKDEQGKAIGDKQEVLVAYANHKGKLVKPAGEQKANKDILYGPYQGETLIAITYSNYGSELDNSQVIIIGGEQVQRAVAAGERTLLVFNGEEGSITLEYNKLDEAAITSLTEQVIKENK
>NC_012914.1|WP_015843386.1|2102991_2104743_+|beta-galactosidase
MKLTIPRPEYPRPQWVRPDWINLNGQWQFEIDHGKSGKERGFQEPGLELSGTINVPFCPESKLSGVEYKDFMAAVWYKREIILPDDWANDGRVLLHFGAVDYEAEVWVNGTAVGRHRGGYSSFSFDITSAVSAGSNVITVYAVDDLRSGRQPRGKQCGGYYSSGCDYTRTTGIWQTVWLERVPEAYLAGMKLVPDPDNACAHLELQLGGSGFKAGTKLAVKALYEGAAAGEAAITVSGPSAKLTLPLSTVHLWQPGSPELYDLEISLVRDGQTLDSVQSYFGLRSVKLDGMAFRINGKSVFQRLVLDQGFYPDGVYTAPSDEDLRKDIEISMGLGFNGARLHEKIFEPRFLYWADKLGYLVWGEHANWGLDITTSEGLAGFLPEWLEGMERDFNHPALIGWCPFNETWDKDGTKQNNEVLRIVYEVTKRMDPTRPVIDTSGNFHVITDIFDVHDYDQNPETFRARYEPMRNGGEVFNTFPKRQQYEGQPYFVSEYGGIWWNPEQKDEKSWGYGDRPVSEEDFLARYAGLTDTLLDHPMMFGFCYTQLYDVEQEVNGLYTYDRREKFDPELIRRINSRKAAIED
>NC_012914.1|WP_015843385.1|2102069_2102969_+|carbohydrate-ABC-transporter-permease
MKYQSISSRTFDVMIYVLLTVLTLCCLYPIVHIIFASVSDPARLVAHKGVLLKPLGLTIDGYKLIFKDNSLLVGYKNTILYVGLGTLVNMLMTIMGAFVLSRRDLYFKKYIMIIITVTMFFGGGLIPWFLLMKDIGLYNNLWAMILPTALNTWNMIVLRTGFQSIPTELEEAAIIDGASQLKLLVNVILPLSKATLAVIFLYYLVGNWNSWFNAMVLLKDRDQFPLQLLLKEILVANDSTATTQGSAGGVVIDSASSATAFRELVKYCTIVFSTLPILMVYPFLQKYFVKGVYVGSIKG
>NC_012914.1|WP_015843384.1|2101136_2102051_+|sugar-ABC-transporter-permease
MRTGQIIKKDVRKNWFVYLLAVPVIAWFVIFCYGPMWGLLIAFKDFKPLLGFSNSDWVGLKHFIDFFGGPYFWRVVKNTLMLNVWGLAFGFTAPIVLALLLNEVRDGKFKKLVQTITYMPHFISLVVVCGMIHIFTEDEGVITQLLQLITGKDYTSLLGYSQFFRPIYTFSDIWQTIGWSSIIYLAAMSSIDSTLYEAADMDGIGRLKKMWHITLPQISPVIIILFIFAVGGIMASSYEKIILLYNPLTYDRADVIASYVYRRGLREASLSYSTAVGLISSLVNFALLWVTNKIASRKSEVSLW
>NC_012914.1|WP_150106635.1|2099303_2101040_+|extracellular-solute-binding-protein
MKKRLLNLLLVSVLTGSALAACSNNNNDPKESADPAATTDSSQAPAVTTAFSDISPTIRGNKAPTQEQMDEVNNTLNDTYLGDLYDEKIPSHYDAYPYKKDVTLDVWLPADSQIPDMNNQVVQKQVEKLTGIKVNFITPPVGQEADAFTLMMSSGELPDIIIEPERYPGGLEAGVKDGAYLDLTDYMDKYAPNYSEWRNSDETRRKTTVTDSGKLLGFYGIAPYSEWMWFGMLIKKEALDKTGLEVPNTIDEWHTFLTKAKEVGYSEPLNYGSTYGQIFTGIINGAYGVWDWTFMDADGKVQWGPAQPKAKDYLATMQQWNKEGLLNKDWATADFNQRMASAISAKTAVMMDSPDTMWSYWKQQNNIDFVGALNPVLNAGDKAATTYKNFKRTGRSAAVTTQADDVEAAMRFLDFAYSKKGWEILNYGEYGKVHLVDETGKPYFQPDSYIYKDPDGQPVATTLVKYRMHSWPDIRDEHNSNPLIVAEGSYSGDIRKTWTENMDTSVAMPPITFTTEEASREAELGNQLSTLRNEYFAKIIKGQLPVDAYDKFLSEAKKMGLDEFLSIHQAALDRYNAR
>NC_012914.1|WP_015843382.1|2098145_2099099_+|glycoside-hydrolase-family-43-protein
MTQAETFNNPIVANAGDPWVYKHTDGYYYYMCTRGNRLVLTQSASLTGLAGGRKQTIWTPEAGGPYSSNLWAPEIHFLNNKWYIYYTANDGGGDDTRRICVLENEQADPLEGEWAWKGALQTPVPGLDGTVLEMGEQLYFLYAGYGHFPDYGSAIYIMRMTNPWTLTGEQTMLTAPTLEWEKQGGMAINEGPVMLKRNGRVFLIYSASTTWSEDYSLGMLTMEDSADPMAADSWTKTMQPVFKKSVENGVYATGHNSFTKSPDDQEDWIVFHALHAPGVETKHRATRIQKFGWHSDGSPDFGVPYGDTFALKVPSGE
>NC_012914.1|WP_015843381.1|2097087_2097927_+|AraC-family-transcriptional-regulator
MEHCNESFIVSIDRFKPHTFHLEEGDGLFISHSHDYDELTLVLDGEGYYSSPEQNIKVSAGSLILIPPGLHHGFVCTKPWRGVSVHFNHERIPLQSRYLFHAGYECNRIHHIQLAEEDTEWAEISYSQLEKEWKKDRSSMDSFNIMRIAFETVIVLFQRYQALFSQTAGGKNDQTVIHEVLKEIHARFYSQLTVHELASKHFVSESNLRKKFTEIVGVSPKQYMINLRMEEAKRLLRQTDKAIESISSEVGFTSSSRFYDFFVKSVGVTPFEWRKQNMK
>NC_012914.1|WP_190276185.1|2095887_2096973_+|peptidyl-prolyl-cis-trans-isomerase
MNRNLANQRKGSFSRLKRMWWIAGGVLLLASAGLAVAWPQPTGGSPSGSEAIATVGGQPISLDEFRLYMDKAKGEVTNYFSVTYGAEDRKDYWTSAFGGERPIDRLKKQAMKDAVEGKTLQLLAVENGLAESSSFADFTRNWNDNNQSRAKDLKQGKAIYGLGEYDLSQFYFYSISNLKLDLAEKLGERELKVTDQELLDRYQSHAEFAGQTQLTYKELSIPFGDGEREQAYKQITEAQQELKAGLSFEEAAKKYTENGLRDNTVIIGGQDSPLQADAVLKQAAARLEIGEYSPVLDCGSGFSIIRLVNRTDNFSVPLDSVKAQLQEEVLQLKFQAYLADQVKKRNVQIKQDVYDQLKKDQ
>NC_012914.1|WP_015843379.1|2094452_2095937_+|alpha-L-fucosidase
MGVTIKEAAQIVPSSRQLAWQETEFYAFIHFTVNTFTDMEWGTGEESPGIFSPTELDARQWVKACQSAGMKGLILTCKHHDGFCLWPSQYTDHSVKSSPWKQGDGDVVKETAEACREAGLKFGIYVSPWDRHEASYGDSERYNRYFVNQLTELLDGYGELFCVWFDGACGEGPNGKRQVYDWDAYYEVIRRLQPGSVISVCGPDVRWCGNEAGHTRLVEWSVVPASLRDNEKIQANSQQTDSGEFARRLGSEEEDLGSRKVLAETDRVVWYPAETNTSIRPGWFYHKHEDDKVKSVDELVDLYERTVGGNSTFLLNLPPDRRGLIHEQDVSRLQELGRELKKRYRSNLASEANVTASASLNEEHEGAKLTDGHLHTFWRTAEGTESATIELQWKNRITFDRVTLKEHIREGQRTERFYLEWHDGADWHPLYEGQVIGYKKICRFEPVETDRIRIRITESRGYPTLREAGVYWTDMGDEHESEPGESEERKLFSP
>NC_012914.1|WP_015843389.1|2108626_2109277_-|hypothetical-protein
MIKFEQAFDEWMQGMISEEDNQRRRELLEKGLGHGTIEFLRLVWFPAAGSFKHLYPEWEVQDFHNGYRYLDLAYMPGGDAKGGIEIQGYGPHARDLDVRRFKDLCWRHCLLALDNWVFLPLAYLSIVDEPKRCQQLVLSFIGKFIATDVPESLGCLEAETIRYARRLLRPFMPSELAAHLRVSDQYARRILIRLVELRLLRVASGKQRYRTYALRV
>NC_012914.1|WP_150106636.1|2109588_2110575_+|cell-wall-hydrolase
MIHSMQKSVKIMSCVMALALLWLSAGPLASVSAAEAGATVRVNGENAKLSDSIITQKNRMYVPAARIATMLGAEVSWDSNNEELTIDTAYNDEVVFGNGVPVVYFNGSRYKMDAVPFMEDGRMYVPLRQLADTLHADLAWDTDSNTAKLTDVDRAAVTDEYGLAEISKEYGISAATLLKRNGLNSKEQVKPGTKLKVVIPSFLDNPASSFTQSDLTLLAKISQIEAGRDSYEGQLAIANVILNRVKDSRFPDSIHDVIYSGKQFPPAHNGLLDKSKPNASALRAAKDALNGRNNVYDAVYFYNPNVTRGAFWSNLEVVARIGGHNFAR
>NC_012914.1|WP_015843391.1|2110708_2111278_+|TetR/AcrR-family-transcriptional-regulator
MPPKAEMTKEKVLAAAFELVREQGLTALTARSVAQKLGCSTQPIYSVYGNMNDLKDDVYEKAVQFALSSMKAYENDSNVPVLNLAIGSLHFAQAEKQLFKAVYLSGHKKYTSQKDKFIAEEMYTAYFRSRGRLSRISDEKLRKIVKALSVYLIGLGTMINTNTLDLSIEEATAMIQDMYEALLMKEDQQ
>NC_012914.1|WP_015843392.1|2111274_2112138_+|phosphotransferase
MIKPGACVGTGGCAEVYEWGDDRVLKLFRSDTTREAVSNEFRSSMVAWEAGLPAVRPYELMDYEGSCGIIYEKLAGRSIKERLFAPEHLERDVRLDVMDSDVRVMARMLHAIHQIKTPAGLNGQKDDLKRSIAWPAYLSNGEKQRVFAYLDSLPDGDRLCHGDPNPGNFMIHNGNPVMIDWMNATVGNPLADIAEFILIFIAYVWPPETPASLKDYFQAHRSRINDIFLDEYKRLSGVTDEEIDAWILPVAARKLSADALQEEEKKHLTAIIREKLSRIGPDTQLYK
>NC_012914.1|WP_015843393.1|2112279_2114139_+|assimilatory-sulfite-reductase-(NADPH)-flavoprotein-subunit
MQLQVTNSPFTGEQAELLNKLLPTLTGSQMQWLSGYLAFYGAGNNTALASVAAGAAVAEAPVTALTVVPAVPQGPKDATILFGSQTGNAQRLAGRLAEKLKAQGFEVTLSAMNKFKTNKLKEVGYLFILASTHGEGDPPDNALTFYEFLNGKRAPKLDGMKFSVLALGDTSYEFFCKTGADFDSRLAELGAERIVDRVDCDVDFEDAAAGWLAAVSGAVSAAPSAAAAPQGAAVSASPAAAGESEYSRSNPFMAELLDSLNLNGRGSDRETRHLELSLEGSGLTYAPGDAVGVYAQNEPALVDDIITLLNWNADEKVVTGKAGETSALREALLHHYEITVLTKPLLEKAVAFSGNAKLAELVKPENKEELKAYLNGRDLLDLLRDFAPWTLKAADVASLLRKLPPRLYSIASSIEAHPEEVHLTIRKVEYEAHGRDRKGVCSVFVSERLQPGDKLPVFIQQNPNFKPPVSPETPVIMVGPGTGVAPFRAFLEEREESGADGQTWLFYGDRHFVTDFLYQTDWQRMLKDGVLSKLDVAFSRDSDEKVYVQHRMLENGAELYKWLENGAHVYVCGDEKHMAHDVQSALLTIIGQYGGKSPEDAAAYLSALQEQGRYQRDVY
>NC_012914.1|WP_015843394.1|2114210_2115935_+|assimilatory-sulfite-reductase-(NADPH)-hemoprotein-subunit
MAKNHKVEPVGGPPSDVEHLKLESNYLRGSLTDSLANRITGGLPDLDNRLLKFHGSYMQDDRDYRNEREKQKLEPYYQFMLRVVTPGGVATPEQWLLMDSLADKYGTGSLKLTTRQAFQLHGVLKWNLKKTIQEINAAMLSTLAACGDVSRNVMCNPNPYQSELHSEVFHWSQQLTSHLAPKTPAYHEIWLDGEKVVDGAEQGEVEPIYGPVYLPRKFKIGIAVPPSNDVDVYSQDLGYIAILGEDGKLAGFNVCVGGGMGMTHGDTATYPQLAKVIGFVTPDQVLDLAEKVVTIQRDYGNRSVRKYARFKYTIDRHGLPWFMDELQDRLGWELAPAREFHFEHTGDRYGWIKGKDGKWNLNLYVQAGRVVDTEDNKLRSALREIAKIHTGDFRLTANQNLVIANVTAQKKTKIVALLKEFGIAEGSNYSALRRSALSCVALPTCGLAMAEAERYLPSLIDRLEPILANAGLQDQEINIRMTGCPNGCARPALGEISFIGKSPGKYNMYMGAGFTGDRLSKMYKENIGEDEIIDTLTPIIDRYASERNKGENFGDFVIRAGYVKAVTDGTNFHD
>NC_012914.1|WP_015843395.1|2115980_2117144_-|ROK-family-protein
MITGDASYIKKMNRSLILKEILKEGMLSRADVSKVTALTRATVSGQVADLLDEELVIETEIEYNQVGRKPIMLSINAEAGYAIGIDLEYDQISFAISDLKGSLVLTDTIKLQSHAYADILSLLTGQIKHYQERFAASRYGIIGIVIAIHGLVSTDEVIHYIPSFGWHDVPLKSDLENALGLQVKLENNANLSAFAERVFFHHETDDLISVTLYSGIGMGMMINHSFFRGQDGFAGEIGHMIVVPGGLPCNCGNKGCWEKYASETSVFQLLRAKKPDADITYAQIGNWIEAKEPDATELIEQFIYYLSIGLNNIINIYNPEVVVLDSELLRIYPDSLQHIESNLNSRVSHYREIKISTIGKKSCVLGACAIAIQNFLRVPVLNLPYKR
>NC_012914.1|WP_015843396.1|2117318_2118587_+|DUF2088-domain-containing-protein
MGILQDLVKDIPIPRMAKVKVNFDDAKIEDIASELLPKLQREQITSRVKPGMEIAIAVGSRGLDRLVEITAVTVKFLKDAGAKPFIVPSMGSHGGATAEGQREVLAHLGVTEETAGCEIRSSMGVVQLGELPNGLPVYLDKFAAAADGIVVINRVKPHTAFRGNVESGIMKMISIGLGKQRGAEACHQLGFKYMAENVPAMAKLIMEQKPVLFGVASIENAFDKVRFIETLTPDEIVEREPQFLAQAKELLPKLFFDQLDVLIIDQIGKNISGDGMDPNITGRYPTPYAHGGPDVNKMAVLDLTHQTEGNANGVGTADFTTQRLVDKMDLEKTYANGLTSTVVAPTKIATTLPNDRETIQASIKTCNILHFDQVKMVRIKNTLEIGEIEVSEALLEYVKHHPRMEVVKDLYDLDFNIDGNLF
>NC_012914.1|WP_015843397.1|2118614_2119388_+|SDR-family-oxidoreductase
MTTNLFDLTGKTAVVIGGNSVLGSYMAAGLAAHGAHVAIVGRNLEKAQDVVDSIISDGGSAKAFQADVLSKESLLKVQSEIEAWRGGCDILLNAPGKNSPTPFFELEMEEWDDIMDVNLKGIVLTCQIFAKRMIEQQRTGSIINISSVSSTTPLSKVFTYSVSKAGLNSVTQFLAREFAEQGIRVNAIIPGFFPAEQNRKILSEERVASIMRHTPMNRFGTPEELQGAAVWLASEKASGFVTGTLIRVDGGFGSMTI
>NC_012914.1|WP_041613387.1|2119396_2120206_+|ATP-dependent-sacrificial-sulfur-transferase-LarE
MEVPTEKYVALQDILREMGSVVVAFSGGVDSTFLLKAAVETLGTGNVLAVTADSETYPTSELEEAKKLAKQIRVQHEVISTSELAIPGYAENNKNRCYFCKSSLFDHLYPLLEERSFANLVYGVIADDKNEHRPGMQAAKERGVRGPLLEADLYKQEIRELSKVFGLPTWDKPSFACLSSRIAYGERITNEKLLKVERAEAYLKSLHIRQVRVRTHDEIARIEVEPGDMPLVLAHHEEIVGQLQAFGYKYVTLDLLGYKSGSMNRSLNL

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Crispr_ID: NC_012914_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012914_6

3764006-3764073

Orphan

Consensus_repeat	Method
TTTAGATTTTGATCTTAGATTTCTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012914_6

>merge|NC_012914|6|3764006-3764073|CRISPRCasFinder
TTTAGATTTTGATCTTAGATTTCTTGATCTCTAAGTTTGATCTTTAGAGTTTTGATCTTAGATTTAGA

>NC_012914|6|5|3764006-3764073|CRISPRCasFinder
TTTAGATTTTGATCTTAGATTTCTT	GATCTCTAAGTTTGATCT
TTAGAGTTTTGATCTTAGATTTAGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012914.1\|WP_015844860.1\|3748159_3748657_+\|2,4'-dihydroxyacetophenone-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|380436
NC_012914.1\|WP_015844869.1\|3766459_3767863_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340879
NC_012914.1\|WP_015844865.1\|3762812_3763016_+\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_015844863.1\|3751988_3753920_+\|fructose-1,6-bisphosphatase	unknown	unknown	gnl\|CDD\|377726
NC_012914.1\|WP_015844870.1\|3768001_3768892_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_012914.1\|WP_015844876.1\|3773682_3774195_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|224523
NC_012914.1\|WP_041613485.1\|3750235_3750466_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_015844862.1\|3750645_3751068_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319899
NC_012914.1\|WP_015844875.1\|3772843_3773383_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_041613487.1\|3770871_3771972_-\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	unknown	unknown	gnl\|CDD\|224919
NC_012914.1\|WP_015844874.1\|3771959_3772688_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187586
NC_012914.1\|WP_015844859.1\|3747062_3747833_-\|arylamine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366312
NC_012914.1\|WP_015844867.1\|3764334_3765357_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274817
NC_012914.1\|WP_015844861.1\|3748793_3750095_+\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|293786
NC_012914.1\|WP_015844866.1\|3763056_3763410_+\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_083778147.1\|3751444_3751618_+\|DUF4367-domain-containing-protein	unknown	unknown	gnl\|CDD\|379540
NC_012914.1\|WP_015844872.1\|3769869_3770826_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223540
NC_012914.1\|WP_049790155.1\|3765359_3765776_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_012914.1\|WP_015844871.1\|3768960_3769845_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_012914.1\|WP_015844864.1\|3754402_3762694_+\|glycosyl-transferase-family-36	unknown	unknown	gnl\|CDD\|225990

Protein	Function_ID	Function_description	E-value
NC_012914.1\|WP_015844860.1\|3748159_3748657_+\|2,4'-dihydroxyacetophenone-dioxygenase-family-protein	gnl\|CDD\|380436	cd20302, cupin_DAD, 2,4'-Dihydroxyacetophenone dioxygenase (DAD), cupin domain. 2,4'-Dihydroxyacetophenone dioxygenase (DAD) catalyzes the oxidation of 2,4'-dihydroxyacetophenone to 4-hydroxybenzoate and formate as part of the 4-hydroxyacetophenone catabolic pathway. This enzyme is a homo-tetramer containing one iron per molecule of enzyme. This enzyme is an unusual dioxygenase in that it cleaves a C-C bond in a substituent of the aromatic ring rather than within the ring itself. As a bacterial dioxygenase, DAD plays an important environmental role in the aerobic catabolism of aromatic compounds; expression of this enzyme in appropriately engineered microorganisms has the potential to use these aromatic pollutants as a carbon source and thus remove them from the environment. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	2.74162e-48
NC_012914.1\|WP_015844869.1\|3766459_3767863_-\|MFS-transporter	gnl\|CDD\|340879	cd17321, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.13161e-41
NC_012914.1\|WP_015844863.1\|3751988_3753920_+\|fructose-1,6-bisphosphatase	gnl\|CDD\|377726	pfam06874, FBPase_2, Firmicute fructose-1,6-bisphosphatase. This family consists of several bacterial fructose-1,6-bisphosphatase proteins (EC:3.1.3.11) which seem to be specific to phylum Firmicutes. Fructose-1,6-bisphosphatase (FBPase) is a well known enzyme involved in gluconeogenesis. This family does not seem to be structurally related to pfam00316.	0
NC_012914.1\|WP_015844870.1\|3768001_3768892_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	3.18323e-49
NC_012914.1\|WP_015844876.1\|3773682_3774195_-\|acyl-CoA-thioesterase	gnl\|CDD\|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	3.73346e-58
NC_012914.1\|WP_015844871.1\|3768960_3769845_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	1.59687e-16
NC_012914.1\|WP_015844862.1\|3750645_3751068_+\|VOC-family-protein	gnl\|CDD\|319899	cd06588, PhnB_like, Escherichia coli PhnB and similar proteins. The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.	1.13382e-38
NC_012914.1\|WP_041613487.1\|3770871_3771972_-\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	gnl\|CDD\|224919	COG2008, GLY1, Threonine aldolase [Amino acid transport and metabolism].	1.09059e-57
NC_012914.1\|WP_015844859.1\|3747062_3747833_-\|arylamine-N-acetyltransferase	gnl\|CDD\|366312	pfam00797, Acetyltransf_2, N-acetyltransferase. Arylamine N-acetyltransferase (NAT) is a cytosolic enzyme of approximately 30kDa. It facilitates the transfer of an acetyl group from Acetyl Coenzyme A on to a wide range of arylamine, N-hydroxyarylamines and hydrazines. Acetylation of these compounds generally results in inactivation. NAT is found in many species from Mycobacteria (M. tuberculosis, M. smegmatis etc) to man. It was the first enzyme to be observed to have polymorphic activity amongst human individuals. NAT is responsible for the inactivation of Isoniazid (a drug used to treat Tuberculosis) in humans. The NAT protein has also been shown to be involved in the breakdown of folic acid.	6.66208e-72
NC_012914.1\|WP_015844867.1\|3764334_3765357_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274817	TIGR03858, LLM_2I7G, probable oxidoreductase, LLM family. This model describes a highly conserved, somewhat broadly distributed family withing the luciferase-like monooxygenase (LLM) superfamily. Most members are from species incapable of synthesizing coenzyme F420, bound by some members of the LLM superfamily. Members, therefore, are more likely to use FMN as a cofactor.	0
NC_012914.1\|WP_015844861.1\|3748793_3750095_+\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	3.64413e-12
NC_012914.1\|WP_015844874.1\|3771959_3772688_-\|SDR-family-oxidoreductase	gnl\|CDD\|187586	cd05325, carb_red_sniffer_like_SDR_c, carbonyl reductase sniffer-like, classical (c) SDRs. Sniffer is an NADPH-dependent carbonyl reductase of the classical SDR family. Studies in Drosophila melanogaster implicate Sniffer in the prevention of neurodegeneration due to aging and oxidative-stress. This subgroup also includes Rhodococcus sp. AD45 IsoH, which is an NAD-dependent 1-hydroxy-2-glutathionyl-2-methyl-3-butene dehydrogenase involved in isoprene metabolism, Aspergillus nidulans StcE encoded by a gene which is part of a proposed sterigmatocystin biosynthesis gene cluster, Bacillus circulans SANK 72073 BtrF encoded by a gene found in the butirosin biosynthesis gene cluster, and Aspergillus parasiticus nor-1 involved in the biosynthesis of aflatoxins. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	4.44628e-58
NC_012914.1\|WP_083778147.1\|3751444_3751618_+\|DUF4367-domain-containing-protein	gnl\|CDD\|379540	pfam14285, DUF4367, Domain of unknown function (DUF4367). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 229 and 435 amino acids in length.	0.00860688
NC_012914.1\|WP_015844872.1\|3769869_3770826_-\|ATP-binding-protein	gnl\|CDD\|223540	COG0464, SpoVK, ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones].	1.23206e-77
NC_012914.1\|WP_049790155.1\|3765359_3765776_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.21294e-20
NC_012914.1\|WP_015844864.1\|3754402_3762694_+\|glycosyl-transferase-family-36	gnl\|CDD\|225990	COG3459, COG3459, Cellobiose phosphorylase [Carbohydrate transport and metabolism].	0

>NC_012914.1|WP_015844866.1|3763056_3763410_+|hypothetical-protein
MIRKYTTGPLNNLTEKDKIVSKDIVVNSLNQNQHEKARVTIKVYSLNGKKKLIHNVSFIVKPHASTYNSFFVGNAKQYEVQFITNQSKVQFASFGISPKDHFVAAHRVINSELTRIL
>NC_012914.1|WP_015844865.1|3762812_3763016_+|hypothetical-protein
MNKIEIQDPKVASKIIAANAENDKRKAELGFLGKFFGSGENVRLYIVGTITLGVLLIALVYTLIPDQ
>NC_012914.1|WP_015844864.1|3754402_3762694_+|glycosyl-transferase-family-36
MSTTNEQLRERAHELALQQQIKSAAGRSGYIKRQVETDIARIRAFVALLQDAPVGCGQQAEEWLLDNAEFIEEQVLNLKMHLSESVLIHLPRLRGEERLRIHALCLAYLEQVEGILDERTLLAFLGAYQEISVLTLAETRLIPIMLKVSLIGKIAETMALVRDRREVCSQVEQLLKQIEPARLSTETIGTALEQAGQIPPLSGPWAAHLISHLREWSGDSAAVREWLVCTYENGSDDLDRIVTYEARLQVSYQIKAGNLITSLRSNERRNWEELFEAISLLDRTMREDVTGLYPRLDTSSRNGILNRIEEVARRLRVPESLVASQSLALAKHAYERGSVIPVHIENKATEQEHAQEELTRQAFAAYYVFEPAGIKSLVQALNKCSKPRTMPLKGLVKSAPMNYFSSLLALFMLLLVVVAAWVVDWNTITTAGIAAVFLALLFPVSEWVMTGLNFGIERICRAKPLLRFDYSSGIAAEAATMVVIPAIWSTVQEVEELADRLEVHYLGNRDPNIHYALLGDFTDAKEENLPSDEILVAAVKARIDRLNRMYGDSGTTFHYYQRARHWNPGEGTFMGWERKRGKLVEFVNLLRGSEDTSYAVTHGDRKVLPGIRYIITLDADTQLPIGSAQRLIGTLHFPYNRPRLNKAGTRVVEGYGVLQPRIGTSHDSAMRSRLAHFWSDPGIDPYAFTVSDPFQDAFGTGIFTGKGIFDVNVFAQLLGERIPDNTVLSHDLLEGGFLRAALVSDIELIEEHPSTFLSFQKRMHRWVRGDWQLLCWLRTKLCDRRGELQPIDLSLLTRWQIIDNLRRSLLPIAMLVLFGLAVTVLPGYPARWLAFLFLTLLLPLIRQLAIMNSAGTHSKHVLSTLVMAGIGFWTLPFQTAVLLDAIVKTLYRMAVSKRGMLEWTSFSQTERSQAEARRRMILGGRGGYLLILLFAAAVVLQPSIPLLLFGLALCLFWALAPVAVRWLDQPVLKAERPLEAADAEQLRTLAKEIWQFYEDYAGKEDHYLPPDNVQIEPPNGVAHRTSPTNIGFLLTAALAARELEFITTPMLVERLERTVGVIERMEKWNGHLYNWYDTSTLELLRPSYVSTVDSGNFVASLMTVKQGLIRWLQTDGWGKGSRRRGQAPLAAVGTEFAIELDRIHPEEMYEARRESNVKQDEPMHATTGWIGQGYELVDRLERLIVSTDFRQLYDNKAKLFVLGYHADSGQRETILYDLLASEARQTSFVAIALGQISVSHWMALGRTAKQQGGHATLISWSGTMFEYMMPWLIMRTYPGTVWDSTYRGVVRRQIAYATGRNVPFGISESGYYAYDYQLNYQYRAFGVPGLGYKRGLEEDTVIAPYATIMALPFALREGLQNLERLDQLGGRGQYGYYEAVDFTAQRMPQGETYKIIRSFMAHHQGMSLLTLANMLVPSCMINYFHSDKRVQAAELLLIERIPQKAALLNRELPGRSRSGGETKLPQNEPLREFAEVPAPLPEANVHGNGSLTTVLTETGSGFIRYNGLDLTRWREDPVMDPWGSFIYIRDVEKSVCWSPTYLPCRKQADRASVQFRKERTTFLREDDGLQTKLEVTVSTEHNAELRRLTLTNATQEARIVEITTYMELAMAAHNADKAHPSFTKLFVQTEFASEEQCLLARKRPRNDDEKALWAFHTLRVDEDQGAAEFETDRAAFIGRGHTLANPRGLAARLGGTFGAVADPAFIMRKRVHVEPGKQISLTAVTGAAESKKQALEIVSQLSSASQAERTFQMAWTRSQIDLQHLRIGEQEASAYQLLAGRVLFASPLRPEQEASISANTKGQPGLWAHGVSGDRPIILVSVAETSSLPFMNKLLVGYEYLRRKGLSFDLVIWNESSGGYQQELRDSLQRMIEQHVHNLNNGAGVHIVAATEQSQEDKNLLFAAARLLLHAEGPSLRAQLLPRESGSTGQLPELVPTSPQNLYSDKPSRDEGAGLFFNGYGGFSTGGDEYRIVLRNGQHLPAPWINVIANQNFGFLASELYTGQTWWSNSRECKLTPWSNDPALDPPGEAVYIRDESSGEYWGMTPSRKAESKTVHTVSHGQGYSRYEHERHGLSHEMTVFVPLDDPVKIIRLRLTNETSDVRKLSVTYYAEWVIGVNREENASHIVTEWDSEHQMLLARNTYQDTFRKATPFLAMHPRTLESGPSWTGSRLSFIGREGDLEDPAAMRKVRLSEETGPVHDACGAIQGIVSLEPGEDGVVYILLGCGDSRDAATQLARKYSEADACEKAYRDARAFWKDINGTIQVATPSAEMDIMLNNWLLYQSLSCRMWARTAFYQSGGAFGFRDQLQDSLSMLHVRPEMTRAQIIRHASHQYREGDVQHWWHEETHRGIRTRFSDDLLWLPYAVIRYLEQTEDESLLTETAPFLQSELLKEDEHERYEETVLSEENGTILEHCFRAIDRALRFGEHGLPLMGIGDWNDGMSNIGPQGRGESVWLGWFLGEVLSGIAEICERYGKRSRAERYLSARSKLENDMQEAWDGNWYRRAFTDSGEWLGSVRNAECRIDAIAQSWSVISGMAPKERAQQAMHSFDRELVDRHLAVAHILTPPFDKTKPSPGYIQAYPPGIRENGGQYTHGVIWSIVAWSILGDGDKAFELFHMFNPITHTKSSFDARTYVGEPYAMAADVYTEHPHRGHAGWTWYTGAAGWMYQAGIEWILGLKKRGQKLLIQPCIPAEWPEFTVTYTYKSTAYRIIVRNPSRKSGGCTALRIDGKETELSMNLMGESPFITLEDDLLEHVVELTL
>NC_012914.1|WP_015844863.1|3751988_3753920_+|fructose-1,6-bisphosphatase
MDAQFLDLLAQKYDTEEKVVTEIINLEAISNLPKGTEHFVSDLHGEFQAFQHVLRNGSGTVKEKIKALFREDWTDHEINDFTALVYYPEEKIQLVKGDLCNKQALNRWYRKTIEQMLKLISFASSKYTRAKLRKALPEQFVYIVEELLYKTDLTNNKDPYYEEIYRQIISLGQADKLIIGLAYTIQRLVVDHLHVVGDIYDRGPDPDKIMDTLIDYHSVDIQWGNHDVLWIGAYAGSLVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYYNDNPAFRPKLQTDHNGSEQEILQITKIHQAIAMIQFKLEIPIIKRRPYFNMSNRLLLEQIDYDKNEIKIGGKTYPLENTCFATVNPQQPEQLLEEEQQVMEKLLLSVQHSEKLARHMSFLMKKGSLYLIYNGNLLFHGCIPLDEEGNMEEMQIEDKKYSGRQLLDVFEYYLRYAFAHPEDTDDLATDMVWYIWTGECSSLFGKKEMTTFERYFIQDKETYKERKNPYYHLREVEEICRKILLEFVMNPDHGHIINGHTPVKEIRGENPVKANGKMVVIDGGFSKAYQSTTGIAGYTLLYNSFGMQLVAHQKFISKEDVLCNGTDVLSVKRLVDKELERKLVRETNVGEKLLQKISNLKNLLEYRYMK
>NC_012914.1|WP_083778147.1|3751444_3751618_+|DUF4367-domain-containing-protein
MSGEIIKFNELEARFTPWGKSSKPGGFIRWIQEGTYIEIVSSEISKKKMIKIAESMK
>NC_012914.1|WP_015844862.1|3750645_3751068_+|VOC-family-protein
MEVQLTPFIMLDGVAREAIAFYEQALDAKVVFKQTFGEAPGEAGQAVSEQARDRLAHSVLKIGGTDLFVADTNPEVRFAQGKQVNICVTVVDKEQARKYYEALKEGGQVVLPLQEIHFSPAYGMVTDKFGVTFQIFTKRA
>NC_012914.1|WP_041613485.1|3750235_3750466_-|hypothetical-protein
MASCRRQIAPLYQAELKEVIQAYEVNDLPLSKTIELLSQKMQEIERKKDELEQVQTHLARMLANKMALLKSAEKES
>NC_012914.1|WP_015844861.1|3748793_3750095_+|ankyrin-repeat-domain-containing-protein
MTDKKNHLVISDDELDKSIIEQFKQGVSGYDPEAVERLLQLHPLLAVKIDEPWFAFDAPAIVSAANRGDRKMVDVLLEYGANINAKSSWWAGGFGVLHHDHYDLSRYLIDKGAIVDPHAAAALGKLDALRKMVEEEPDIVNLRGPDGQVPLHYAGSPEIIDFLLSHGADIDRRDLDHNGTPAQYAVNNLERCRHLVQRGAQTDIFMACKLGDINLVRRMLKEDPNLLQVQVGKGDFTAPGGHIYEYNIGGAMRPLFFAERLGHEEITELMLSYSSVEQRLLLACMRADRRAVDSLLMEYPGIVQSLQPEEQGFIADAAWNNQTDAVQLMLEVGFHVDARRSERSATALHHAAGQGNDKIVQLLIDHGASVDVLNEFGGTPLNSCIWGSLHILNPDGNYAEVAENLVQAGAKLPNQAAGSEHVKQVLFRHGASY
>NC_012914.1|WP_015844860.1|3748159_3748657_+|2,4'-dihydroxyacetophenone-dioxygenase-family-protein
MNSLIEESVIKLAEKFQLPERIVNIEDLPWVPFTDNHSCYFKPLRFDLNTGTWIYLFKIKSNQILGRHRHTGGSVIGYNIQGKWRYEGREWVAVPGTFIFEPPGDIHTLITQDEEVVTLFILSGSLQYFDENGQIIGQDDIYTVLNKYKVYCDLHGIETRDDLIY
>NC_012914.1|WP_015844859.1|3747062_3747833_-|arylamine-N-acetyltransferase
MDVKSKVQLYLDRIGYDGPLDRSAQSLADLQDCHLHAVPYENLDIVRGMPISLEIDHLFDKIVVRRRGGYCFELNALFGWLLRELGYPVTDLFARFWRDEPSPPPKRRHQVLKVEAGDQTYLCDVGVGGIVPRRPVAMVEGLPHRQGDETYRLDKDPYYGWMLCELKHGEWCRLYSFTEEPQLPKDYIMASYWCEHAPDSIFTKAEMVAIRTREGRNTVAGKEFRLFAQDGVNVFTPQSDEAYKEALRQHFGIQLD
>NC_012914.1|WP_015844867.1|3764334_3765357_-|LLM-class-flavin-dependent-oxidoreductase
MEIGVDTFVETTPDVVTGETISHGERLRQVVEEIVLADKVGLDIFGVGEHHRKEFADSATAVILAAAAPMTKKIRLTSSVTVLSAADPVRLFQQFATLDGISNGRAEIIAGRGSMVDAFPLFGYDLKDYDSLFEEKLELLLKLRESEKVTWKGGFRPAFNNLGVYPRPVQNQLPVWLGSGGNPDSVIRAGQLGLPLVLAIIGGSPLNFAPLVPLYKKAAARAGHDVSKLKIAVHSLGYVAESNSLAVDKYFPPTQASFNYFGRERGWGQYTRSQFDASRTLEGALFVGDSETVANKILFMRKQLGFTRFFLHLPVGTMPHEDVMKAIELLGTEVAPRVRE
>NC_012914.1|WP_049790155.1|3765359_3765776_-|MarR-family-transcriptional-regulator
MVNELYRSLERDIDSYGLSTENFRILELLYNRGAQPIQKISDTFTIPSGSITYVVDKLEKKGLVERIPIPGDRRKTNVSLTAAGRSSFDNIFPKHAQFISDQLTFATDEEKFELINVMKKIGYGIKNRENKDNHKQED
>NC_012914.1|WP_015844869.1|3766459_3767863_-|MFS-transporter
MPAEQPDVRPPAIGNVLIKLLAFTLVLSSMSATMFNIVLPEIRADFELTVAQVSWVSTAYLLIYAVGSVIYGKLLDRYQAKNLITFGLLVFASGSLLGLLAGSFPFVLMARILQAVGASVIPALAMLIPVRYFPPERRGHALGISVTGLALGNAIGPIVSSLLVSVVHWRWLFAIPLLILITLPFYRKHLSSDIKEGGTIDWLGGGLLTGTVALLLLAITQGNLWLGAGSALMLIGFLWRIRAAADPFISRALMRDRIYLMGLMIAAIVMSISYALPFLTPQLLSDINRLEPGIIGFVMVPGACLSAYLGRKVGKLADSKGNSFVYHTASLLLFSCFLLLSLFVGSPAVLIGLIFTLGNVGQMFMQIVLSNTISRSIPRDQIGVGMGLLTLCNFLSGAVSTGIYGKVMDHGARSSWIPWHSNAASYVFSNLYLILALIHIVLLLLYRSVYVSRKKTNTTGQMLSNQR
>NC_012914.1|WP_015844870.1|3768001_3768892_+|LysR-family-transcriptional-regulator
MELLQLHYFRTVAKYEHMTKAAEVLRIAQPALSKTISRLEEDVGVPLFDRNNRQIRLNRFGRAFLQQVEIALGALDEGRRELADMMGTEQGTIRLATPTLNRLSSTISEFRKENPEIIFRVTQIPPASSSDMIGLLERGDVDLCFIAAPLNQSWIKEQIILKAEVCLAVPITHPLASKDTITLIETANEAYIEYHAGHPFRQINEAYCEAAGISRNIICEVDEPSALWSLVQAGLGVAFVPRNTNEHPHVKLLNIQSPVCEREFSIAWNEKRYLSRASRQYLEFLKSYKQHDLIGN
>NC_012914.1|WP_015844871.1|3768960_3769845_-|tetratricopeptide-repeat-protein
MEEETLTPSSHTGYTNVYQLMFWKKYKEALIETEKLLRDDPHSPDPYALYAQICVLMGDYEKARHWVDEALKRDPEHHLGWYVRVSLFYETGNEAAFHEAVREALRIDPYEAHYYYLQANQLNKKGKFKEAKEQIGIALELEPENPQYLSILSYTEALLGNDAVSRETEREALRYGAEEPIVLMYLAWSAARRGDYKLHETYMRSAVRLNPDEKQYQDEYLESLQNQYILYRICLWPNKLFRKMKPWQIFVMWAVCWLLFKPLVLVFIILHLIAHWSTKAIVHVKIFGWRRRRT
>NC_012914.1|WP_015844872.1|3769869_3770826_-|ATP-binding-protein
MSDYDELSERRRNKLKLMQFDKDEHSLVESDKPKETFEDVGGLEEVKKKIRMNFILPLQQPEIFKAYGKEAGGSLLLFGPPGCGKTFLARAVAGEIDANFIHIELQAILSMYVGQSEHNLHDVFQKARENKPCVIFIDELDAMGGSRHQMRQHHERMLVNQLLTELDGLQSGNDQVFVIGATNTPWYLDSALRRPGRFNHLVFVPPPEEEERSTILQLKLAGKPASSLNLGKLAAETKLFSGADLEQVVNDAVTSAMERTFETGDIQPITQDDLRKALKERKATTIEWFATARNYATFSDVNGDYKIVLDFAKKHGIK
>NC_012914.1|WP_041613487.1|3770871_3771972_-|DegT/DnrJ/EryC1/StrS-family-aminotransferase
MELVKTLLEAFNTAEYPVVGHGKRNVQVLKDTFDHLDGEVDSDIYGTGKVIEDFQAKIAAYLGKPSAVFFPSGTMAQQIALRLWCEEKGSRKVAYHPLCHLEIHEQDGLKELHHIEPILLADKDRLITLDDVKNMDEDIACLLLELPQREIGGQLPAFEELEAIAAYCRAKDIRLHLDGARLYEILPYYGKTAAEVCSLFHSVYVSFYKGIGGIAGAVLAGEEEFTKQSKIWKRRHGGDLISLYPYILNADQAFDERLPKMEQYYRSAVELAGLYNCGIEGITTRPLVPVSNMFHVHAAMPKEIFEKILIAVYEESGIGLTGNVRDAGEGASYYEVSLGDRYPAIPKDRLKQAFELLHEKVKQTAK
>NC_012914.1|WP_015844874.1|3771959_3772688_-|SDR-family-oxidoreductase
MQMIRTLLVTGADRGVGMAIAAKWLEDGNRVFAGQYADSPGLQELQRLYGEQLTVFPLDVASDASVKQAYDWVRSRTDKLDVLINNAAILGDIRNTILGELQYEEMLSVFNVNALGSLRMSQAFTPLLLQSDAKLIANISSEAGSITDCWRDAWYAYCMSKSAVNMQSKLIHNGLRPQGGRVLVIHPGWVKTHMQGKLDEAAELTPEQSAAGITKVIQSAITRDAAEMECEYVDYEGRKLNW
>NC_012914.1|WP_015844875.1|3772843_3773383_-|hypothetical-protein
MEQASKPQQDATNIPQEEFFAAAALFCRAYPVFVAEIDRVESERGRLNDFQLMRAVNKAKEGLVILGWDCRKAVNALFDTYVEIYKHSSKDGANEWAESTFGCNKTLIYEPPLEEEEILEHGLTLDLRIEQLTALIHEQEATLLQNYRDLYRLKIAAAHEAEAENSLEELEQNNKQFEE
>NC_012914.1|WP_015844876.1|3773682_3774195_-|acyl-CoA-thioesterase
MEQRFSRESRCYKTSRIFPTDVNNHNTLFGGKLMAYIDDIASIAATKHCRRAVVTASTDSVDFLQPIRPSDSVCLESFVTWTGRTSVEVFVKVIKEDLLTGERIVAATSFLTFVALDQNRHPVPVPKVIPESEEEFKLYETASHRAEMRRIRREESKKFADYLTVAHPWD

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Crispr_ID: NC_012914_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012914_7

4619198-4619295

Orphan

Consensus_repeat	Method
CTTAACGATGCGCGGCATCGTTAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012914_7

>merge|NC_012914|7|4619198-4619295|CRISPRCasFinder
CTTAACGATGCGCGGCATCGTTAAGACCGTCCAATAATGCCTTTTTGGCCGGTAATCCGGCTAACTTGCGGACCTTAACGATGCGCGGCATCGTTAAG

>NC_012914|7|6|4619198-4619295|CRISPRCasFinder
CTTAACGATGCGCGGCATCGTTAAG	ACCGTCCAATAATGCCTTTTTGGCCGGTAATCCGGCTAACTTGCGGAC
CTTAACGATGCGCGGCATCGTTAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012914.1\|WP_015845643.1\|4631968_4633129_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_012914.1\|WP_015845632.1\|4615864_4616689_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012914.1\|WP_015845642.1\|4631079_4631940_-\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NC_012914.1\|WP_015845638.1\|4624380_4626873_+\|family-43-glycosylhydrolase	unknown	unknown	gnl\|CDD\|350105
NC_012914.1\|WP_015845641.1\|4629224_4630835_-\|cellulase-family-glycosylhydrolase	unknown	unknown	gnl\|CDD\|365907
NC_012914.1\|WP_015845630.1\|4612538_4613846_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270451
NC_012914.1\|WP_015845640.1\|4628113_4629082_-\|glycoside-hydrolase-family-25-protein	unknown	unknown	gnl\|CDD\|119373
NC_012914.1\|WP_015845639.1\|4626914_4628021_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_012914.1\|WP_015845631.1\|4614056_4615799_-\|family-43-glycosylhydrolase	unknown	unknown	gnl\|CDD\|350141
NC_012914.1\|WP_049790064.1\|4605967_4607332_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_012914.1\|WP_150106680.1\|4622325_4624083_-\|glycoside-hydrolase-family-127-protein	unknown	unknown	gnl\|CDD\|369609
NC_012914.1\|WP_015845627.1\|4608395_4608959_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_015845635.1\|4619385_4621146_-\|glycoside-hydrolase-family-2	unknown	unknown	gnl\|CDD\|225789
NC_012914.1\|WP_015845628.1\|4609091_4610720_-\|response-regulator	unknown	unknown	gnl\|CDD\|227095
NC_012914.1\|WP_015845644.1\|4633175_4634054_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012914.1\|WP_015845633.1\|4616693_4617587_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_012914.1\|WP_015845636.1\|4621309_4622242_+\|ArsR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226652
NC_012914.1\|WP_015845626.1\|4607489_4608317_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319
NC_012914.1\|WP_041613529.1\|4610735_4612526_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NC_012914.1\|WP_015845634.1\|4617665_4618985_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270451

Protein	Function_ID	Function_description	E-value
NC_012914.1\|WP_015845643.1\|4631968_4633129_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	3.46734e-56
NC_012914.1\|WP_015845632.1\|4615864_4616689_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.08864e-77
NC_012914.1\|WP_015845642.1\|4631079_4631940_-\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	1.54212e-15
NC_012914.1\|WP_015845638.1\|4624380_4626873_+\|family-43-glycosylhydrolase	gnl\|CDD\|350105	cd08991, GH43_HoAraf43-like, Glycosyl hydrolase family 43 protein such as Halothermothrix orenii H 168 alpha-L-arabinofuranosidase (HoAraf43;Hore_20580). This glycosyl hydrolase family 43 (GH43) subgroup includes Halothermothrix orenii H 168 alpha-L-arabinofuranosidase (EC 3.2.1.55) (HoAraf43;Hore_20580). It belongs to the glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) which includes family 43 (GH43) and 62 (GH62) families. This GH43_ HoAraf43-like subgroup includes enzymes that have been annotated as having xylan-digesting beta-xylosidase (EC 3.2.1.37) and xylanase (endo-alpha-L-arabinanase, EC 3.2.1.8) activities. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	5.74217e-90
NC_012914.1\|WP_015845641.1\|4629224_4630835_-\|cellulase-family-glycosylhydrolase	gnl\|CDD\|365907	pfam00150, Cellulase, Cellulase (glycosyl hydrolase family 5).	7.86301e-27
NC_012914.1\|WP_015845630.1\|4612538_4613846_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.36606e-81
NC_012914.1\|WP_015845640.1\|4628113_4629082_-\|glycoside-hydrolase-family-25-protein	gnl\|CDD\|119373	cd00599, GH25_muramidase, Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family of muramidases contains a glycosyl hydrolase family 25 (GH25) catalytic domain and is found in bacteria, fungi, slime molds, round worms, protozoans and bacteriophages. The bacteriophage members are referred to as endolysins which are involved in lysing the host cell at the end of the replication cycle to allow release of mature phage particles. Endolysins are typically modular enzymes consisting of a catalytically active domain that hydrolyzes the peptidoglycan cell wall and a cell wall-binding domain that anchors the protein to the cell wall. Endolysins generally have narrow substrate specificities with either intra-species or intra-genus bacteriolytic activity.	4.16969e-69
NC_012914.1\|WP_015845639.1\|4626914_4628021_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.67183e-47
NC_012914.1\|WP_015845631.1\|4614056_4615799_-\|family-43-glycosylhydrolase	gnl\|CDD\|350141	cd18820, GH43_LbAraf43-like, Glycosyl hydrolase family 43 proteins similar to Lactobacillus brevis alpha-L-arabinofuranosidase LbAraf43 and Geobacillus thermoleovorans GbtXyl43B. This uncharacterized glycosyl hydrolase family 43 (GH43) subgroup belongs to a subgroup which includes enzymes with beta-xylosidase (EC 3.2.1.37), alpha-L-arabinofuranosidase (EC 3.2.1.55) and possibly bifunctional xylosidase/arabinofuranosidase activities, similar to Lactobacillus brevis alpha-L-arabinofuranosidase LbAraf43 and Geobacillus thermoleovorans IT-08 beta-xylosidase / exo-xylanase (GbtXyl43B). It belongs to the glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) which includes family 43 (GH43) and 62 (GH62) families. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	9.45786e-146
NC_012914.1\|WP_049790064.1\|4605967_4607332_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.71545e-56
NC_012914.1\|WP_150106680.1\|4622325_4624083_-\|glycoside-hydrolase-family-127-protein	gnl\|CDD\|369609	pfam07944, Glyco_hydro_127, Beta-L-arabinofuranosidase, GH127. One member of this family, from Bidobacterium longicum, UniProtKB:E8MGH8, has been characterized as an unusual beta-L-arabinofuranosidase enzyme, EC:3.2.1.185. It rleases l-arabinose from the l-arabinofuranose (Araf)-beta1,2-Araf disaccharide and also transglycosylates 1-alkanols with retention of the anomeric configuration. Terminal beta-l-arabinofuranosyl residues have been found in arabinogalactan proteins from a mumber of different plantt species. beta-l-Arabinofuranosyl linkages with 1-4 arabinofuranosides are also found in the sugar chains of extensin and solanaceous lectins, hydroxyproline (Hyp)2-rich glycoproteins that are widely observed in plant cell wall fractions. The critical residue for catalytic activity is Glu-338, in a ET/SCAS sequence context.	1.00902e-46
NC_012914.1\|WP_015845635.1\|4619385_4621146_-\|glycoside-hydrolase-family-2	gnl\|CDD\|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	6.17673e-51
NC_012914.1\|WP_015845628.1\|4609091_4610720_-\|response-regulator	gnl\|CDD\|227095	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms].	8.75335e-68
NC_012914.1\|WP_015845644.1\|4633175_4634054_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.13107e-56
NC_012914.1\|WP_015845633.1\|4616693_4617587_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.31242e-82
NC_012914.1\|WP_015845626.1\|4607489_4608317_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	6.82981e-47
NC_012914.1\|WP_015845636.1\|4621309_4622242_+\|ArsR-family-transcriptional-regulator	gnl\|CDD\|226652	COG4189, COG4189, Predicted transcriptional regulator [Transcription].	1.53488e-109
NC_012914.1\|WP_041613529.1\|4610735_4612526_-\|histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	5.68808e-62
NC_012914.1\|WP_015845634.1\|4617665_4618985_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.34856e-99

>NC_012914.1|WP_015845634.1|4617665_4618985_-|ABC-transporter-substrate-binding-protein
MKKSMKVLGTSLIALSLVAAAGCGSNSNNGGKDAGSNNQANSGANAAAGNSGDAKAEKADILFWTPFSGADGEFMKKIVEKYNSSQDTYKVKLVIQPNGEYYKLLDVAMSAGKDRPDLAIMHVDQIPTYVNKGQLQPLDDLAAAASINKTDYVEAPVNYETIDGKWYGIPLDIHPLVMYYNKDLFDKAGITAPPTNRAEFEADVEKLTDKAKGVYGYVVPTLWPQQFIFPTLVWQNGGDLWNGTDVAYNSPEAVEMVQWMRGLVDKGVSPGNVQQDGENTLFLQGKNAIQFNGPWMKGQFDEAGIKYGVAPVPQIGKAKQAVYAGSHNFVLPKGVTDANVVKGIGDFLKYVSTNSMDWAASGQALASKPMLESAEFKALDMQSNVAKSFDYVQFAPNVLNWGTISDPIWGELSNALLGKKDAQKAMDDAVAKSRQAMKK
>NC_012914.1|WP_015845633.1|4616693_4617587_-|sugar-ABC-transporter-permease
MVKSSLQSRLTSTLFVLPYLLSFCAFLLIPILYGIYISFHNFELLSDSHKFVGFDNYVKIFTPGSYLFEQFTTGLWNTVQFVLYSVPLLVILGLALALLLNQLPKRIRGLFRTFYFMPYAISGSVMAVIWLMMFDTNAGFLNGLLAKLHIDPVAWLTDLPWVWVSLVLTTLWWTIGFNMIIFTNALNEVPEDYYEAASIDGANAWKRFVSITLPSIRPVMLFIIITSTIASFNVYAQPFLLTRGGPGDSTKVLLMNVLDEAFKGKQVGSASAMAILMALIIIIVSAVQYKIAYGRKE
>NC_012914.1|WP_015845632.1|4615864_4616689_-|carbohydrate-ABC-transporter-permease
MKKTLLVLVAVIIAVIFLLPLIWMLSTSFKNDFEALAGQLSLIPKKPTFENYLDGLKGNLMNVPITRWISNSLFVGAAGTAIVLLFSSMAAYALARLQDLPFKKLMFPIFIGSMMIPGVLTFLPMYLEFNALGWINTYAALILPYSSGAFGVFLLFQFFTAFPKEIEEAARIDGANKWQIYSRILLPASVSIMVTLAIFTFMGIYNDFVWPLYSTTSPEMRTITAGIAMMAQGSYTQAYGKLMSMTVIATLPVFIIFIVGQRSFVKAITQAGVK
>NC_012914.1|WP_015845631.1|4614056_4615799_-|family-43-glycosylhydrolase
MNAKRWAVLTAAVLLVAAASIGVWVMNDSTNEASQVAAEYKGHGGTFKNTLAEIDTPDPAVVYKDGYYYMTFTHNGADIMVMKSRTIDFKQSERKVVWYPDIGTNYSAELWAPEIQFIQGKWYIYFAADDGQNENHRMFVLEADTDDPMGSYTFKGQVKDDTDKWAIDGLAMELNDKLYFVWSGWEGDINVQQNTYIAPMSDPLTISGPRVLLSEPDLEWEKAGGPPYINEGHSILHHNGQVHIVYSGAGSWTPFYALGMLSLKEGADPLVASNWTKAQEPILKMDEDAGVYGPGHNSFVTSPGGTEQWIVYHATTAATDGWGNRKARAQKLAWDEAGNLRIGKPISLDTAIEVPAGMGVFKAAEASADVSFDLIPSTIHTAAPLLIHYLNDTGEKLQAGVSVNGEQAVDVELPETDGTGYAYADISLAAGMNEVHIAIAGGQGKIDAIELPRYEAEYAAAGTQGEAEENLFSSAGGKAVITPGEGEALRFANIQVPVSGAYEIRLAAANSSGHDAELQVRIDGSGGKSKRIVFPNGKRNNYQTQSVILQLKAGKNAIILENATAEVHVDYMDILRSSAQ
>NC_012914.1|WP_015845630.1|4612538_4613846_-|ABC-transporter-substrate-binding-protein
MRGLSFRSYLTSGLSIIIAASLTLTGCSHSNNGTAASAEPKAPAIQLNYWTPFSGGDNLFMTEMVDQFNKEHEDIQVVQMNSRLDDYYSRLRTAILSGNAPDVAIIHASSLPQFVQNGYIEDLSGPAQEAGLDWNLYNKAGMKAVSFQGKPYAVPLDTHMLVMYYNKTFLEQAGVLDAQGKPVLQGGEDGFTHFLQQIKQAVPSDVAPLAQPSTRIDAVWFWWSLYNQIQGGGKFYNAEGTKAVLNNPAALKALNYIDGLYKSKLIPPNIPDSFKLFNEGKAAVLITGVWATGALEKNDALNFGVVPLPTIYDKPAAWADSHTLAIPSQHDMSQEKRDAAMLFMKWLAEHGAKWAEAGHVPSASAVMDTEAFKSLNYRSDYAAAANSVVFWPKHTKQHSFIEVIIRQFERMIYGQQTPEQALQATEKQINLELSK
>NC_012914.1|WP_041613529.1|4610735_4612526_-|histidine-kinase
MMTFYRRLQQWFKNLALARKLILVNVLLIVVPLGVIGAWSFSIFASKMEEQVGKYQLQMLKQVTLNIDTYMNELNRLSLMPYQYQEILDFLATSRKPGEALSLQEIDDLNNFVSKVFLNGRVDIMGISLFGEHGASYVVLPESQYMTTYQLGGNTEWLEKAKGRFGQPTFITTHEVKSTSGTAYQVFSIARELRSFDSGDTLGYIVIDIDPAEVRKLLSQVSLGSKESLYMTDSAGDLVLRKEKTAIYPVIEGLSDEGVSHHKIDGKSLLVAHVSSEVTGWTTVGVVPVSVLMKDSLVVRNSIILIGGICVGLAVLLSVFIAFRITSPLRMLRSLMRKVERGDLKVSFPVRQWDEVGQLGNAFNMMVSHLSELGYRLYETEIREKDAEIAALQSKINPHFLYNTLGSISMYAEVEGNREVVTMTNNLSRLLRYSLSGRKETVTLRDELDHVKGYMTIQKMRYDDRIDFRLEVDESLYGCPVIPLMIQPIVENAINHGLDKGIGEGRIQLSCYQEQGMLMIVIEDDGIGMTSEQLSAMRKRMDKIHDLGGTSGNGLMNVHRRIRLHYGEQYGLQLESMPFQGLKVILTMPIAYSMTG
>NC_012914.1|WP_015845628.1|4609091_4610720_-|response-regulator
MPNILIVDDEAIFRRGLRKMIESSSGSWEVAGEAKDGYEALEMVESLKPDVLLTDIRMPRMDGLQLIQIAKERFPKLLVIVLSGFDEFTYLQQSLRHGVRDYLMKPVEREELFKTLGKLESELAKLQQQVPELYTAEPADARIIRQHVSEHLVAGLLKGYVNETDLALLARIGVTFQEPCFACMIIKLDKDLLDKERYEKADPSLFQLYIQQIVQELLDQRAKGFSFILSETEVVALVNLPGQPGAGDPLFELSETIRRRMISLSRLTVTIGLGRTVGGIKEIPQSFHEAKIAQLHRLIVGGDRVISYSRIKDGEEEMAWSSLLELPLELLESSIQEGKREQTRQYAAMFVTALCSQARSPEVIHQQICKLLIHGYEEAEKLELTQSWLGDRTIQAVLLEICSLTSRTELIDCCSAYLEKLAECIANGQKNADHDPIEKVIRYVNQHYQEPLSLTQVAEKVYLNPAYLSTLFKQRTGSSLVEYWTELRVSEAKRRLVSSNEKVTIIAESTGFGNIRHFNRVFKSVTGFAPIDYREQARSVKV
>NC_012914.1|WP_015845627.1|4608395_4608959_-|hypothetical-protein
MGIKSKIVLFCFILALLTCTLVIIRQSGEQGMERAALSLNQPMARVAYIEKLGKMNAIVFYDWGTYPEYFGTARLKKTIFGWHFTGGSTSAEPKEHKFGWSFNGLKGDLKGDVPHYAGMYSGKIYDSEIVSMWKKSRSSGKELPCQIIEYGAGERFWFYLSEQEEGPDSVILARSRTGEILEQYPSE
>NC_012914.1|WP_015845626.1|4607489_4608317_+|helix-turn-helix-domain-containing-protein
MDDSVRLKELAQFLKTRRARLSPEQAGLPASGRRRTPGLRRGEVAMLSGVSVDWYTWLEQARPIQVSAQVLDCISRALQLDADERKHLFLLAIQQVPADPSLDQNRISDNLQIFLDRQGTSPAFITDQRLIIRAWNKAADLIYGPFESMSERERNTVWRSFHLPGVRELLKENWEKHARHRLAQFRAGYAKFPGDAWWLEMIDELQRTSEEFREWWPQHDVLNGPEGKKVNYHPVAGTLEFNQLSFIVSDSPQFTVTVNLPADEQTVSKLEQLLI
>NC_012914.1|WP_049790064.1|4605967_4607332_-|MFS-transporter
MEKALQQVSGRSRLLLLGLSLGYFMVLLDMTVVSVALPAIQEDLGGGIIDLQWVVNAYTIVFAGLLLSMGVFADRLGAKRVYVGGLILFLAASAASAAVTTTGALIALRAILGIGGAALLPASLTLLSHAYPVPGERARALGAWTAVTGAAMAAGPVVGGILVDSFGWRSIFLLNVPIAAVSLLLTCMQLEETPRFAHRSFDAGGQVTALAAIAALSFSLMEGQYYGWGSPVILGTVGLAALSMILFVFTEAKGQAPLFPLSLFKNSTVSTGLIAGMAINVGLSGVLFVLPLYFQQSKGLSAHDAGLSLLPMMLPLAFNPILTGRIVSRIGARKPMAAGFGLGAAGTLILAWTHSGTSYAWTFIGLLMIGFGVSFTIPSLMAAVMSSVAREQTGAVSGAINASRQLGSVLGVALLGAVLNGSQSFLSGMRISFILIAILLAGGSVLTLAVFGKK
>NC_012914.1|WP_015845635.1|4619385_4621146_-|glycoside-hydrolase-family-2
MTNLPRAEYPRPQFNRNAWECLNGEWEFEFDDARVGGEEGWHSGSKSFSKKIQVPFSFESELSGIGDPNFHDVVWYRRKLDIPKSFQGKRVVLHFGAVDYEAYVWVNGQLVASHEGGHTPFQADVTEALRSDGDNTLVVKAVDHGMDVFLPRGKQFWEEKSRSIWYTRTTGIWQSVWMEAVSPVHLRKVKYVADIDTNEIQIRSFVGGFAQGMKNVSLSVKISFAGEVVSEDTYQVRAGEESRKIKLSGLNDHGMDRFWWPERPNLYDAEFVVYVDGAEVDRVTSYFGMRKISLENGKFNLNNRPYYSKLVLDQGYFPDGNLTPPSDEAIKQDVVLMKEMGFNGARKHQKVEDPRFLYWCDKLGLIVWGEMANACDYSEEYVRRITKEWQEAIDRDFNHPCIAVWVPLNESWGVPNIQVDVRQQQHALAMYHLTKSIDPTRLVISNDGWEMVATDLYNIHDYEWRREVLEDRYGSVEKAVSAMPANRRLSVAGYEYDGQPIIITEFGGIAYKKSEWEGWGYSGASSDEDFVERLRNVIQPLIFSGVVQGYCYTQLTDVEQEINGLLTYDRKPKVPLELIKAINEGK
>NC_012914.1|WP_015845636.1|4621309_4622242_+|ArsR-family-transcriptional-regulator
MHIQVSTKYMTMLECFSSETRVKMIELLNNGPMSIKELAETLGLSSAIVTKHIQKMEEGGLIKTESLSGTRGSPKMCSLAIDSLTLQLRTSSQEKALNEETKYTVEIPIGQYSDYAVKPTCGLASESKILGLVDDPRYFSDPERMNASHLWFGSGYVEYRVPNYLHAGQAASQLDISLELCSEAPSYNENWPSDISFYINDIEVGIWTCPGDFGSKRGALTPSWWQLGTQNGLLKSLSIQATGTFLDGVKLSEVTLTDVGLKLGEDFRFKLASLETARHCGGISLFGRHFGNYKQDIMVNVYYKDKIRTE
>NC_012914.1|WP_150106680.1|4622325_4624083_-|glycoside-hydrolase-family-127-protein
MTGHLDEFWSHVGPSSGWLGGTGESWERGPYYLDGLLPLAYLLEDERLINKVKPWIDWTLESAREDGQFGPASNDDWWSRMVMLKVLIQHAEYTGDERVIPFMTNYFRYQLKQLPERPLADWAKARGGDNLISVYWLYNRTGDPFLMELAQLLIVQTEDWKGLYEQYPYWYRQTSFDHRVHVVNVAMSFKQPALQYLLTGDETDKAVVYKAINSVMACHGQVNGMFSGDEWLAGTHPSQGTELCSVVEYMYSLENLIRITGDGFFGDILEKIAYNALPAAISPDWKVHQYDQQANQIMCTHAKRNWTENNNEANLFGVEPHFGCCTANMHQGWPKLAARLWMASEGGGIAAISYAPCLVTAALGSDKKTKAEIQVETSYPFRDTVNIKVGLESSAAFAMKLRIPAWCEEPVLQINGEPYPLQPVNGFVSIERIWMPEDELLLTLPRHATLIPRANGAAGVQYGPLMLAIPVKEQWQKHRTYPPYHDWELYPQSPWNYGVELNELTLADKGRVLEEEVRRQPFAADNPPLRMRVNARRIPQWTMEMNSAGTPPVSPVASKEPLEEIELVPYGCARLRIAEFPVLLR
>NC_012914.1|WP_015845638.1|4624380_4626873_+|family-43-glycosylhydrolase
MRLKKWKTLLVGAAAAVMLMPLHVSAYSNPITISDSWHWANNDFYGEGDPYILKFNGTYYLYVSTVDDQSGVKVWSSTNLVDWSYRGLCTTEAITKAAYAPEVVYWNGMFYMYTSPGGGGHYVLQSTSPTGPFTVATGNLGMGIDGNVFIDDDGKWYFYSTGSNTINARPMTSPTAFGAAVGTGLSMAGWTEGSTTFKRNGKYYMTYTGNHVWSTGYRVNYATSASPTTGFAPADSQNPVLIDTEGSNVGLGHNSVIKGPDLDSDFMVYHSHASNGNLTYPGRKMNLDRIAWNGDKMLVLGPTTASQQNPELADFEDRFNRTSIGTGWTTIGGGTWGIYNQELMWQDTIGNTNTYRQVTSAGTAGDYTAEFNTKQMKQGTSSNPVYGTVFSYTDESNYGTAVLNRSLNRLETNFVVGGVSQGWQYSALPSGYDYTKWHQIRVEKAGTSFTVFVDGMKKQTRTVSGIGGGKIGYTTTDAHADFGYTAFSNKVNGSSAWNAYKPLPGKIEAVHYMNGAEGTAYHDLTADNIGGAYRSGSVDIRSSAAEGKNVVGWNQTGEWLKYRVNVAETGYYDLDVRLATTFTDASYRVWDGATDLTGVVGVPSSGDWETWITSSKKGLYLTAGYHELRFEFVKGEFDFSGMTFSRGDAVTSLSDDFNDGNDNGWTRFEGNWSVNSGELDSAGGGVFGKTTIGNERWADYTVESDIKLVDTTGDAGVLVRVNNPSNGTVLVNNPDYIQGYYAFIKPDGVYLGKMNYNYAGVASSPVSLAAGAWHHMKVVASGTTIKVYVNDMTTPKITYTDNSGNPFTHGKVGLRTMNNHTRFDNFKVNP
>NC_012914.1|WP_015845639.1|4626914_4628021_-|GntR-family-transcriptional-regulator
MKDIPLYKQIQEAIKTQISLGNLRPGDRIPSETDLAAQFHVSLMTTKNALAGLAEEGIVVRSKGKGTFVAGQAPYKLFFSADEGSRGGPELPANRHSSSKLIGMIIPSMRTKVEQRLLDAIENAVNSYGYTLVIRVSRGSTAKELQSLEDLGALGIGGLILFSIGAQHERQTVIRAEELECPVVLIDRYYNDMPVVSVCSDNKAGARKAVSYLFRKGHDRLALLTPPVEHSVMADRLAGFESAVTDCGLKPSSVLRYTVPYERFNVSRKDGAELINQWMLMHHGSFSGLVATDVELARLAYHALKRINRAADKQLVAFDDTGIPEVAYIRQNETAIGAKAVSLLMGHIARGEQLQGRFVIPTQLILPS
>NC_012914.1|WP_015845640.1|4628113_4629082_-|glycoside-hydrolase-family-25-protein
MQGRTKGNAQGIDVSHYQGTIDWSKVAGDGITFAFVKATEGENYKDPTFLQNANGAAAAGLLVGAYHFLRATSSAAAKREAQYFHQTASQASSLLLPPVMDYETNSGNLSDAGMSAVAKAFLEETERLFGVKPIFYTGNAFANHFDISLSNYSLWIARYNATTPPDDAKAWTKWTFWQYSDGSSGGTLPSGTRKVSGISGNVDLNEYAGTEDDLLRAYAPEEDKPMTEAEKQQMEELQQRIAALETHVNISGNQTPPSWTKTSTSAAMKAGIITSVNDKGMPEFITIQMLYNAGLCNAELIKFFKEFSADTRKAIEDLLKKK
>NC_012914.1|WP_015845641.1|4629224_4630835_-|cellulase-family-glycosylhydrolase
MKLKKVLTLAVTACLAVGMMGSIKVQHADAAIGASDFLKTNGKQIKNNNGNGSVVSLHGTNLGGWMMEENWMSPLGGTDEWTVRGTLINRFGSSAVDSLKDSYQDLWIQASDLDTIKNMGLNFIRVPIYWENMMNRDGTMKSDAVSFGNLDWLVSNAQSRGLYVLLDLHGVPGNMNGWQSGGREGANELWSNTTYQNWVVQLWQRIATHYKDNPTIAGYDLLNEPVSNNGSLSISQMYDRLYKAVRAIDPDHMIYVEAFGYWNNIVAPSTYGWTNVVYEVHSYDWNDTDWNSQNNSINQWFSDIIWHQNNWNVPVYSGEFTLFTHNDLWEKWLSGLDALDVSWTNWSFKVTSGGNWGLYQNNTNPFPNVSSDSIATMQSKLAKFTTNNFTPNTTLINMFKAYAKLNAPSSLQAKANNLYVTAENTGASPLVANRTSVGTWEKFIVVTNADGTVSFLSLANNKYVSADLNNNGRLIAQAQGIAAWEKFTKSTNADGTVSFKSVANNKYVSADLNLGMLIANRDSVSGWEAFTLTAAP
>NC_012914.1|WP_015845642.1|4631079_4631940_-|sugar-phosphate-isomerase/epimerase
MNKGKIGVQMMMLKGKAEELGVYETLRKVRELGYRSVEVSQIPMTEENVTELRRASLDFDIEIASLSAAVDPMVPGMPGEFLSTHFEKIVADCKTLGCGYLRIPMLPFTSMGDKEAVLEFVRQADSYAERLLPHGISLYYHNHHAEFQKFDGEYLLDIIKNHTKHLGFEMDVHWVQRGGENPVTFIQKYEGRIALIHLKDYRIGALNYDFSKGMDMQGIMNAFNNIVQFAEVGEGSLDISGIMNAGAASGAKYFLVEQDDVYGKDPFHCLETSANNLRKLGYGDWF
>NC_012914.1|WP_015845643.1|4631968_4633129_-|Gfo/Idh/MocA-family-oxidoreductase
MEKVRLGIIGLGAEGGMYAGLLTDGKVNNMVLGAVCDIDPLKRTLAAEKYPEIPFYEDYIQMMESGEVDAIVTCVPHYLHPEMGIEALKRGVHALVEKPAGVYTKQVRELNEFAATKPELTFGIFFNQRTNRLYQTLKKMIEDGEIGAIRRTNWMITTWWRPQGYYDQSEWRATWGGEGGGVLVNQAPHQLDLMQWICGMPTKVYSNVKYGYQRNIVVEDEVTAMFEYENGATGVFVTCTHDVLGTDRFEILGDKGKIVVDGSRKLTIKRLARPESEMSSSMSMQDVMKIFMGHSGNDIYTEEVLEFNDAFGIQHISVMENFAANIIDGTPLIAPGSDGIHGVRLANAIHLSSWLGKEIEVPFDEELFLAELNKRIEAENKYPVNA
>NC_012914.1|WP_015845644.1|4633175_4634054_-|carbohydrate-ABC-transporter-permease
MNDGGKWYQGFLHGFMMILSVLTLFPFVLLLSGSLSDDNEIIRSGYAVIPKMLSFSAYDYLWSDAADIVRAYGITIFVTVVGTVAGLSIIALLSYPLSRRELPFRGPLAFYVFFTMLFNGGLVPTYLVYTNMFDVKNSMLALLVPGLLMNAFYVILMRTFFATSIPPAIIESAYMDGAKEFRIFRSIIIPLSTPVLATVGLFQTIAYWNDWFNGLIYITDPKLFSLQNLLNRILLDVQFLQTSQDSIAMGTHIPLLSMRLAMAVIGIIPILIAYPFFQKYFVKGITIGAVKG

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Crispr_ID: NC_012914_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012914_8

5070518-5070744

Orphan

Consensus_repeat	Method
TAGCCGTAACCAGGTCCCATCTCTGCTGG	CRT

4 spacers

The CRISPR arrays of NC_012914_8

>merge|NC_012914|8|5070518-5070744|CRT
CAGCCGTAACCAGGTCCCATTTCTGCTGGGGATACTGCCGTTGGGCCGTAGCCGTATCCAGGTCCCATCTCTGCTGGAGACACCGCACCTGGCCAGCCATAGCCGTAACCAGGTCCCATCTCTGCTGGGGATACTGCCGTTGGGCCGTAGCCGTAACCAGGTCCCATCTCTGCTGGAGACACCGCACCTGGCCAGCCATAGCCGTAACCAGGTCCCATCTCTGCTGG

>NC_012914|8|2|5070518-5070744|CRT
CAGCCGTAACCAGGTCCCATTTCTGCTGG	GGATACTGCCGTTGGGCCG
TAGCCGTATCCAGGTCCCATCTCTGCTGG	AGACACCGCACCTGGCCAGCCA
TAGCCGTAACCAGGTCCCATCTCTGCTGG	GGATACTGCCGTTGGGCCG
TAGCCGTAACCAGGTCCCATCTCTGCTGG	AGACACCGCACCTGGCCAGCCA
TAGCCGTAACCAGGTCCCATCTCTGCTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012914.1\|WP_015845961.1\|5066520_5067522_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl\|CDD\|234619
NC_012914.1\|WP_015845962.1\|5067542_5068181_-\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NC_012914.1\|WP_015845963.1\|5068177_5068678_-\|crossover-junction-endodeoxyribonuclease-RuvC	unknown	unknown	gnl\|CDD\|234587
NC_012914.1\|WP_015845955.1\|5060901_5061294_+\|TIGR04086-family-membrane-protein	unknown	unknown	gnl\|CDD\|274969
NC_012914.1\|WP_015845973.1\|5078491_5078827_-\|ribosomal-processing-cysteine-protease-Prp	unknown	unknown	gnl\|CDD\|377307
NC_012914.1\|WP_015845967.1\|5073012_5073987_-\|homoserine-kinase	unknown	unknown	gnl\|CDD\|234920
NC_012914.1\|WP_015845968.1\|5074047_5075334_-\|homoserine-dehydrogenase	unknown	unknown	gnl\|CDD\|235783
NC_012914.1\|WP_041613565.1\|5061728_5062865_-\|tRNA-guanosine(34)-transglycosylase-Tgt	unknown	unknown	gnl\|CDD\|234642
NC_012914.1\|WP_015845970.1\|5075936_5077256_-\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237046
NC_012914.1\|WP_015845959.1\|5063966_5066072_-\|SpoIID/LytB-domain-containing-protein	unknown	unknown	gnl\|CDD\|274252
NC_012914.1\|WP_015845956.1\|5061380_5061695_-\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|235518
NC_012914.1\|WP_041613567.1\|5079314_5080565_-\|Rne/Rng-family-ribonuclease	unknown	unknown	gnl\|CDD\|273254
NC_012914.1\|WP_015845974.1\|5078839_5079151_-\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NC_012914.1\|WP_015845966.1\|5072143_5073016_-\|prephenate-dehydratase	unknown	unknown	gnl\|CDD\|237013
NC_012914.1\|WP_015845960.1\|5066071_5066515_-\|DUF393-domain-containing-protein	unknown	unknown	gnl\|CDD\|367833
NC_012914.1\|WP_015845969.1\|5075352_5075790_-\|ACT-domain-containing-protein	unknown	unknown	gnl\|CDD\|179848
NC_012914.1\|WP_049790069.1\|5068839_5069493_-\|BofC-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|370208
NC_012914.1\|WP_015845958.1\|5062912_5063959_-\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	unknown	unknown	gnl\|CDD\|234666
NC_012914.1\|WP_015845971.1\|5077269_5078007_-\|Spo0B-domain-containing-protein	unknown	unknown	gnl\|CDD\|379668
NC_012914.1\|WP_015845972.1\|5078162_5078474_-\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464

Protein	Function_ID	Function_description	E-value
NC_012914.1\|WP_015845961.1\|5066520_5067522_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl\|CDD\|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NC_012914.1\|WP_015845962.1\|5067542_5068181_-\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	4.53704e-74
NC_012914.1\|WP_015845963.1\|5068177_5068678_-\|crossover-junction-endodeoxyribonuclease-RuvC	gnl\|CDD\|234587	PRK00039, ruvC, Holliday junction resolvase; Reviewed.	1.66204e-92
NC_012914.1\|WP_015845955.1\|5060901_5061294_+\|TIGR04086-family-membrane-protein	gnl\|CDD\|274969	TIGR04086, hypothetical_protein, putative membrane protein, TIGR04086 family. Members of this family of strongly hydrophobic putative transmembrane protein average about 125 amino acids in length and occur mostly, but not exclusively, in the Firmicutes. Members are quite diverse in sequence. The function is unknown.	2.81057e-21
NC_012914.1\|WP_015845973.1\|5078491_5078827_-\|ribosomal-processing-cysteine-protease-Prp	gnl\|CDD\|377307	pfam04327, Peptidase_Prp, Cysteine protease Prp. This is a family of cysteine protease that are found to cleave the N-terminus extension of ribosomal subunit L27 in eubacteria. Proteins in this family are distinguished by a pair of invariant histidine and cysteine residues with conserved spacing that form the classic catalytic dyad of a cysteine protease.	6.42236e-35
NC_012914.1\|WP_015845967.1\|5073012_5073987_-\|homoserine-kinase	gnl\|CDD\|234920	PRK01212, PRK01212, homoserine kinase; Provisional.	9.4895e-119
NC_012914.1\|WP_015845968.1\|5074047_5075334_-\|homoserine-dehydrogenase	gnl\|CDD\|235783	PRK06349, PRK06349, homoserine dehydrogenase; Provisional.	0
NC_012914.1\|WP_041613565.1\|5061728_5062865_-\|tRNA-guanosine(34)-transglycosylase-Tgt	gnl\|CDD\|234642	PRK00112, tgt, queuine tRNA-ribosyltransferase; Provisional.	0
NC_012914.1\|WP_015845970.1\|5075936_5077256_-\|GTPase-ObgE	gnl\|CDD\|237046	PRK12297, obgE, GTPase CgtA; Reviewed.	0
NC_012914.1\|WP_015845959.1\|5063966_5066072_-\|SpoIID/LytB-domain-containing-protein	gnl\|CDD\|274252	TIGR02669, stage_II_sporulation_protein_D, SpoIID/LytB domain. This model describes a domain found typically in two or three proteins per genome in Cyanobacteria and Firmicutes, and sporadically in other genomes. One member is SpoIID of Bacillus subtilis. Another in B. subtilis is the C-terminal half of LytB, encoded immediately upstream of an amidase, the autolysin LytC, to which its N-terminus is homologous. Gene neighborhoods are not well conserved for members of this family, as many, such as SpoIID, are monocistronic. One early modelling-based study suggests a DNA-binding role for SpoIID, but the function of this domain is unknown. [Unknown function, General].	4.17728e-45
NC_012914.1\|WP_015845956.1\|5061380_5061695_-\|preprotein-translocase-subunit-YajC	gnl\|CDD\|235518	PRK05585, yajC, preprotein translocase subunit YajC; Validated.	2.70597e-35
NC_012914.1\|WP_041613567.1\|5079314_5080565_-\|Rne/Rng-family-ribonuclease	gnl\|CDD\|273254	TIGR00757, Ribonuclease_E/G-like_protein, ribonuclease, Rne/Rng family. This model describes ribonuclease G (formerly CafA, cytoplasmic axial filament protein A), the N-terminal domain of ribonuclease E in which ribonuclease activity resides, and related proteins. In E. coli, both RNase E and RNase G have been shown to play a role in the maturation of the 5' end of 16S RNA. The C-terminal half of RNase E (excluded from the seed alignment for this model) lacks ribonuclease activity but participates in mRNA degradation by organizing the degradosome. [Transcription, Degradation of RNA].	6.75586e-146
NC_012914.1\|WP_015845974.1\|5078839_5079151_-\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	1.63159e-51
NC_012914.1\|WP_015845966.1\|5072143_5073016_-\|prephenate-dehydratase	gnl\|CDD\|237013	PRK11898, PRK11898, prephenate dehydratase; Provisional.	1.01599e-113
NC_012914.1\|WP_015845960.1\|5066071_5066515_-\|DUF393-domain-containing-protein	gnl\|CDD\|367833	pfam04134, DUF393, Protein of unknown function, DUF393. Members of this family have two highly conserved cysteine residues near their N-terminus. The function of these proteins is unknown.	4.73226e-28
NC_012914.1\|WP_015845969.1\|5075352_5075790_-\|ACT-domain-containing-protein	gnl\|CDD\|179848	PRK04435, PRK04435, ACT domain-containing protein.	1.04649e-74
NC_012914.1\|WP_049790069.1\|5068839_5069493_-\|BofC-C-terminal-domain-containing-protein	gnl\|CDD\|370208	pfam08955, BofC_C, BofC C-terminal domain. The C-terminal domain of the bacterial protein 'bypass of forespore C' contains a three-stranded beta-sheet and three alpha-helices. Its exact function is, as yet, unknown.	2.95998e-33
NC_012914.1\|WP_015845958.1\|5062912_5063959_-\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	gnl\|CDD\|234666	PRK00147, queA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional.	0
NC_012914.1\|WP_015845971.1\|5077269_5078007_-\|Spo0B-domain-containing-protein	gnl\|CDD\|379668	pfam14689, SPOB_a, Sensor_kinase_SpoOB-type, alpha-helical domain. Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain. Two subunits of Spo0B dimerize by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate thereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor. The exact function of this alpha-helical domain is not known; it does not always occur just as the N-terminal domain of SPOB_ab, pfam14682. SCOP describes this domain as a histidine kinase-like fold lacking the kinase ATP-binding site.	5.25891e-17
NC_012914.1\|WP_015845972.1\|5078162_5078474_-\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	1.85123e-54

>NC_012914.1|WP_049790069.1|5068839_5069493_-|BofC-C-terminal-domain-containing-protein
MMMKFSLWKQLKKRLRRGRRPMWTLGSFLIGVTVLVQAVYGTPAAAAAGAAVKEPGEGNPGLIRILQEHEEPLAVQLHRQYICGEETQPLGQLTSAEVIRMLVSHPEWTAMLSQDGQTVLLEQEIEDFSQSCKGNIYIGLDKQGYLSLFEGAPKKEKVVKTFFQLDVKYMESSLPQDKVDRLSEGIKITDMDEYNSVLSTYSDFAMPANQKVMKPTY
>NC_012914.1|WP_015845963.1|5068177_5068678_-|crossover-junction-endodeoxyribonuclease-RuvC
MRVLGIDPGIAIAGFGFIDKDGHKLKPVQYGCIQTAAHTPQEERLVQIYDSAVALMDKYKPDTVAVEKLFFNRNVTTAFAVGQARGVIILAAAQRGLPVAEYTPLQVKQAVVGYGKAEKRQVQEMVKMFLKLSAIPKPDDVADALAVAICHAHSSGLSQKINEVLR
>NC_012914.1|WP_015845962.1|5067542_5068181_-|Holliday-junction-branch-migration-protein-RuvA
MIDFLRGLISHVESEYVVLDVRDVGYQVFTPNPYAFAGKEGTVTIYIHHHVREDAILLYGFESREEQTLFRKLLEVSGIGPRVALGILAGGRPDAVIGAIQQENIAFLTRLPGIGKKTAQRMILDLKDKLAGFATDAGLLAAAGLAPHQPVSAASAQQGAGTAWEEARDGLSALGYTAAELDKAWSALAPSVTADETVDSLMKRALQQLFKG
>NC_012914.1|WP_015845961.1|5066520_5067522_-|Holliday-junction-branch-migration-DNA-helicase-RuvB
MEDRIISANLMMDEQAMELSLRPRYLAEYIGQSKAKENLKIYIDAAKMRKEALDHVLLYGPPGLGKTTLSNIIANELGVNLRTTSGPAIERPGDLAALLTNLQEGDVLFIDEIHRLHRTVEEVLYPAMEDFALDIMIGKGPSARSVRLDLPPFTLIGATTRAGLLSAPLRDRFGVISRLEFYTMDELAYIVSRSAEIFDIAIIGEASEEIAMRSRGTPRIANRLLKRVRDYAQVRGDGIITHEIAKSALELQQVDPVGLDSIDHKMLLAMMTTFAGRPVGLDTIAASIGEESQTIEDVYEPYLMQIGFLQRTPRGRIATDQAYRHLGMPVPER
>NC_012914.1|WP_015845960.1|5066071_5066515_-|DUF393-domain-containing-protein
MKSEREMLYVVYDGTCNLCMGTVRKLQELRSNANLIFVPIQSLGEAGNRVPGIEKVAEAELYEKMHVADEKGRLYAGADGVVRILRTIKGFRLLALLYRLPGLSRVGDLLYRYIAKRRYDWFGRTEQSCSVNGCSVPPQHERGKGNH
>NC_012914.1|WP_015845959.1|5063966_5066072_-|SpoIID/LytB-domain-containing-protein
MNFQRWSFKRLSLLTIAGLLFVSTWWAKPSLGAVPQLDTIRVAIYLQLPGKYQVNTAAATFSSAGGLTIGMSDPSGTVPWINTGANVQSRIAKDDYKVKVIETESFDTALAVYKRLQALSGSGFITSLKKKGKTVYQVTEGTYGNAADATAAMTKWIADSTISKLIGSAKAAIQGPYHLESATTYASEAEAVKASDAFSAAGVDAFVGVRKADGSANVRYSVFVGTAASTAELNVVKTAAGAAGSGLKTADDSAYLLERNDHTLSGKADSPITLYAFPVNNAKVRIMPAGESTIKLTERSSRTYRGQFEVSEFNGKLAVVNELPFEQYLYSVVGGEMIASWPLEALKAQAVSARTYALYQGAGFQIANVVDSVSSQEYQGTVTEKPSTIQAVDETAGEVMLYNGKLIEALFSSNGGGKTADASEIWGNSVAYLKSVSSPTDSSSEKGLYNWYRVVLPNNQTGYIREDLLTDSGQTNAAGVKLMTVNTDASKVRKNPKVEDTVALVGQVNKGTVVAVLDKAVENNAMSWVKGPFTSSELLATMTKQASVTGPITSLQVGTTGPSGRVTQLLVNGQSYNVKYPDVLRSALGGLPSTLFKVDETAKVTMLGANGSTRTKTSSAQPVYMIQAGGKVTQADSNVIVMNGDSQIRATTKDPSFRFVGSGYGHGIGLSQYGALGLAQQGYDYSYILQYYYKDVTIAKE
>NC_012914.1|WP_015845958.1|5062912_5063959_-|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA
MNVDWFDFELPEHLIAQTPLADRTASRLLALNKETGEIAHRTFTDLAEYMNAGDVLVLNNTRVIPARLTGVKPDTGAKIELLLLKQLEGDRWETLAKPAKRIKVGSELWFGDNGSGEPLLRAIVEDEGDMGGRTIRFRYEGIFQELLDRLGEMPLPPYIKERLEERERYQTVYAKHEGSAAAPTAGLHFTKEFLQQLVDKGVKLAYITLHVGLGTFRPMSVDKVEEHEMHSEYYELDEQNAVIINEAKSSGARIIAVGTTSSRTLETVAARFEGGPIEACNGWTDIFIFPGYNFKLVDALLTNFHLPKSTLVMLVSALAGREAIMKAYGEAVREEYRFFSFGDAMFIY
>NC_012914.1|WP_041613565.1|5061728_5062865_-|tRNA-guanosine(34)-transglycosylase-Tgt
MVAVKYELIKVCKQSGARLGRVHTPHGVIETPTFMPVGTQATVKTMSPEELKTMDAQIILSNTYHLFLRPGHDIVGRAGGLHKFMNWDRPILTDSGGFQVFSLSDMRKITEEGVQFRSHLNGDKLFISPEKAMEIQNALGSDIMMAFDECPPYPADYDYVKQSLERTTRWAERCLNSHARKHDQGLFAIVQGGMYKDLRIQSAKDLTSMDFPGYAIGGLSVGEPKHLMYEVLDYTVPELPTTKPRYLMGVGSPDALIEGSIRGVDMFDCVLPTRIARNGTTMTSQGRLVVRNAKFAEDFGPLDPECSCYTCQNYSRAYIRHLLKADETFGIRLTTYHNLHFLLQLMRDVRQAIMEDRLLDFRDDFFTKYGLFDNDKGF
>NC_012914.1|WP_015845956.1|5061380_5061695_-|preprotein-translocase-subunit-YajC
MNAYLAAGEAGGTNIFQMIWPFILMFAVFYFLLIRPQQKKTKQRNSLLSQLKKGDKIQTIGGLQGTIVELTDDIVVLRVNDTTKMTFDRSAISSVLNSAPAATE
>NC_012914.1|WP_015845955.1|5060901_5061294_+|TIGR04086-family-membrane-protein
MNSIKSIARPPRIGSPLIAGVIYSIIWLAIGALLLSFLLYFSNMKENNLPQYSLAVHGLSALAGGFVSGKRSGMKGWYHGALLGLIYGITVLTIGFLAANSGLSGKSAMMLLAAMLAGAFGGMIGVNLKK
>NC_012914.1|WP_015845966.1|5072143_5073016_-|prephenate-dehydratase
MKTIAVLPAGSVSDEAVKRLFAGESMNWKHHRLIADVFMSTVNGVSDYSVVPIENTIEGSVNLHVDWLVHEVDLPIQAEWVYPSIQNLIGRSSEAAGEGGTVDFSQIRKVISHPVAIAQCLQFLRSELPHAEIETAGSTSEGVKIVKENPGQGWAAIGTMTAAGNNGLDVLSRGITDHDNNFTRFLLVGSKPFTARQSDKQKTSILITLPEDYPGALHQVLAAFAWRKINLSKIESRPTKKKLGNYYFYIDIDMALDTVLLPSALEEIEAIGCQVRILGSYPSFTYEQLL
>NC_012914.1|WP_015845967.1|5073012_5073987_-|homoserine-kinase
MNNRRVIVKVPASTANLGPGFDTLGMALSLYAWIEMSAAETTTFRLYGDQMQGIPTDKSNLLYKVAQLVFEEAGVSVPELDVAMYSDIPLARGLGSSASAIVGALVAANALIGSPLTDHKLFQLATKLEGHPDNVGASLFGGIVVSAWDGERADYVRLAPHAKLETLVAIPAFQLATEKARHALPKQISMADAVFNVGRSSLLVAALASGELGLIRHAMRDRLHQPYRAPLIPGMSTILEQAVEYGALGAALSGAGPTLIAFVDADSKSKSELEQFLLATLKQEGIEAETMWLKPGGEGPLITVEDAATPTPGLMERIKGEVVR
>NC_012914.1|WP_015845968.1|5074047_5075334_-|homoserine-dehydrogenase
MKPVKVGLLGLGTVGTGVVRIVEGHQEDLQSQVGSPIVIEKILVQNKSKARSISIDANKLTEDPWEIIGNPDIDVIVEVMGGIGSTKEYIMEALSRGKHVVTANKDLMALHGPEILAKAQEHGCDVLYEASVAGGIPIIRTLVEGFSSDRITKIMGIVNGTTNYILSKMSLEGASYGDVLKEAQELGYAEADPTSDVEGLDAARKMTILATLGFRAKVALEDVSVQGMSKVSKEDILYAKRLGYEVKLLGIAERQDDQFSISVQPTMVKKSHPIASVNGVYNAVYVYGEAVGETMFYGPGAGELPTATSIVSDLVAVVKNLKLGVNGKQSVLTYKEKKLKSDEQISSKYFLLLHVDDRAGVLAQITQIFAEYEVSLESVLQQPNPNNPDAEIIVITHDANKAAIQKVLQKFESLDVIRKVKSVYRVEG
>NC_012914.1|WP_015845969.1|5075352_5075790_-|ACT-domain-containing-protein
MTQRYYVVREDMLPEAIVKTIQVKEMLGRGEASTVHEAVEKVGLSRSAFYKYKDGVYALQELERERIVTISMDLEHRSGVLSKVLALVASLEGNVLTMNQSIPLQGLANVVLSVDISQLNEELTTLIEVIRSQEGVRKAAVIGQG
>NC_012914.1|WP_015845970.1|5075936_5077256_-|GTPase-ObgE
MFVDKAKIFVKGGNGGNGIVSYRREKYVPEGGPAGGDGGNGGDVIFRVDEGLRTLMDFRYQKHFKGPAGERGKVKSMHGASADDMIIRIPPGTVIVDDDTQEIIADMTRHGQEVVVARGGRGGRGNIRFATINNPAPDICENGEEGQERWVTLELKVMADVGLVGFPSVGKSTLLSVVSGAKPKIGAYHFTTITPNLGVVDVGDGRSFVMADLPGLIEGAHEGVGLGHEFLRHVERTRVIVHVLDMAGTEGRDPFEDWVKINEELVKYNEKLSERPQIIAANKMDMPEAADNLELFKQQLDEVRGDREYLIVPISSLTKQGVQELLYKAADTLDSVPEEVSVEEVKDVAERKVFTFEKREDDSFTIHREDEIFVVQGARIENYLKRMNMNSYDAIMRFAQMMRKMGVDAALRREGARDGDTVQIADFTFEFFEGSDYNG
>NC_012914.1|WP_015845971.1|5077269_5078007_-|Spo0B-domain-containing-protein
MDRIRMARQSAAATVVLPGAAVLIWPSSVWLVALFLLWTIAAAVFWIRTERKEQEHRLARTVYMLQTASVKTLNHHRHDWMNDLQVLFGYIRMNKLDKTVEYVEKIRARMTEESQIAKLGVPSLISYIQSFRTLTNAMQLQVKLDEGIYLNELDDGGKTIAETLISLINAYRFSVKTGYGDPAVLTVQLSREEEMLIVAIYYEGDLTSEQQLADKIKQQLEGASLLPVDVEHPQRKLVLKAEWRA
>NC_012914.1|WP_015845972.1|5078162_5078474_-|50S-ribosomal-protein-L27
MLKLDLQLFASKKGVGSTKNGRDSHSKRLGAKRADGQVVSAGSILFRQRGTKIHPGTNVGIGKDDTLFALVEGVVKFERLGRDRKKVSVYPVDLAPVAAAVEA
>NC_012914.1|WP_015845973.1|5078491_5078827_-|ribosomal-processing-cysteine-protease-Prp
MISVTVKRRAADRRIVSFAISGHAKYADRGKDIICAGVSAVSVGTVNAIEALATVELPAVMKNGWLSSDIPEQPDKEIDDKVQLLLESMVVMLGTIAKTYGKYVVIHEQLL
>NC_012914.1|WP_015845974.1|5078839_5079151_-|50S-ribosomal-protein-L21
MFAIIETGGKQYKVQEGDVIYIEKLNVTEGESVTFDRVLAVSNGEGLVTGTPVVSGATVSGKVEKQGKGQKIIVYKYKAKKNYRRKQGHRQPFTKVTIEKIQA
>NC_012914.1|WP_041613567.1|5079314_5080565_-|Rne/Rng-family-ribonuclease
MKRMLMHGHGELLQTAVLMDGRLIDFFMEQSESSGLVGNVYKGRVVNVLPGMQAAFVDIGLGKNAFLYIDDLLHPHLEKQPEHKPSITELVKPGQELVVQVMKEPMGSKGARVTTHFTLPGRWLVYMPIAGYIGVSKKIMAESERSRIRMIGERLRQGEEGIIMRTAAEGECEESLGADVDQLRQLWTSVLQRADHAKAPAELHREAGLLRRAVRDTLTDDMDEVWLDDPSRYSEAVSLLKEMTPHLAGRLKLFEARKEKVSLFDRFGVTDQIEAAFSSRIRLESGGSLVWDETEALTVIDVNTAKYIGATGLEDTVFKTNMEAADEIARLLRIRDVGGIIVIDFIDMENESNREKVMARLSDWAKKDRTKCTVFGWTRLGLLELTRRKARDNAARQLTERCPACGGTGKKSSIHS

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Crispr_ID: NC_012914_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012914_9

5978288-5978612

Orphan

Consensus_repeat	Method
TTAAGGTCCCTTAGGGACCTTAA	CRISPRCasFinder

5 spacers

The CRISPR arrays of NC_012914_9

>merge|NC_012914|9|5978288-5978612|CRISPRCasFinder
TTAGGGTCCCTCAGGGACCCTAAGCTGACCTAAGCCAACTAATTTTACTGTCTTAAGGTCCTTCATGGACCTTAAGGTTCCGTGATCGCTCTGTTTGAACAATATTTGCTGCTTGTTCTGGGTGGTTAAGGTCCATCAGGGGCCTTAACACGACCTTTGCCAACTAATTTTACTGCCTTAAGGTCCCTTAGGGACCTTAAGCTTCCGCGAACGCTCCGTTTGATCGATGTCTGTTACTTTTTCCGGGCGATTAAGGTCCCTTAGGGACCTTAATCCGTCCTGCGCAGGCTAATTTTATTGCCTTAAGGTCCCTTAGGGACCTTAA

>NC_012914|9|7|5978288-5978612|CRISPRCasFinder
TTAGGGTCCCTCAGGGACCCTAA	GCTGACCTAAGCCAACTAATTTTACTGTC
TTAAGGTCCTTCATGGACCTTAA	GGTTCCGTGATCGCTCTGTTTGAACAATATTTGCTGCTTGTTCTGGGTGG
TTAAGGTCCATCAGGGGCCTTAA	CACGACCTTTGCCAACTAATTTTACTGCC
TTAAGGTCCCTTAGGGACCTTAA	GCTTCCGCGAACGCTCCGTTTGATCGATGTCTGTTACTTTTTCCGGGCGA
TTAAGGTCCCTTAGGGACCTTAA	TCCGTCCTGCGCAGGCTAATTTTATTGCC
TTAAGGTCCCTTAGGGACCTTAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012914.1\|WP_015846756.1\|5980626_5980923_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_085982423.1\|5964918_5965590_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NC_012914.1\|WP_015846761.1\|5984679_5985663_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380514
NC_012914.1\|WP_015846745.1\|5963256_5963778_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|376578
NC_012914.1\|WP_015846755.1\|5978947_5980426_-\|alpha-N-arabinofuranosidase	unknown	unknown	gnl\|CDD\|226064
NC_012914.1\|WP_015846750.1\|5974433_5974982_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379237
NC_012914.1\|WP_015846764.1\|5987779_5989393_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270299
NC_012914.1\|WP_015846763.1\|5986876_5987758_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_012914.1\|WP_015846749.1\|5967603_5974086_-\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|200477
NC_012914.1\|WP_015846760.1\|5983658_5984618_-\|carbohydrate-kinase	unknown	unknown	gnl\|CDD\|238572
NC_012914.1\|WP_015846751.1\|5974994_5975834_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_012914.1\|WP_041614676.1\|5962449_5963109_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NC_012914.1\|WP_041613645.1\|5981831_5982650_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NC_012914.1\|WP_015846746.1\|5963857_5964847_-\|acryloyl-CoA-reductase	unknown	unknown	gnl\|CDD\|176249
NC_012914.1\|WP_015846752.1\|5975956_5977030_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_012914.1\|WP_015846748.1\|5965718_5966615_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_012914.1\|WP_049790082.1\|5985862_5986798_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_012914.1\|WP_041613643.1\|5981068_5981848_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_012914.1\|WP_015846759.1\|5982800_5983604_+\|phytanoyl-CoA-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|368580
NC_012914.1\|WP_015846753.1\|5977041_5978199_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745

Protein	Function_ID	Function_description	E-value
NC_012914.1\|WP_015846759.1\|5982800_5983604_+\|phytanoyl-CoA-dioxygenase-family-protein	gnl\|CDD\|368580	pfam05721, PhyH, Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.	8.57439e-32
NC_012914.1\|WP_085982423.1\|5964918_5965590_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	1.19547e-58
NC_012914.1\|WP_015846761.1\|5984679_5985663_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380514	cd06291, PBP1_Qymf-like, ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs. This group includes the ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus metalliredigens (strain Qymf) and its close homologs. Qymf is a strict anaerobe that could be grown in the presence of borax and its cells are straight rods that produce endospores. This group is a member of the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	3.45124e-110
NC_012914.1\|WP_015846745.1\|5963256_5963778_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|376578	pfam01625, PMSR, Peptide methionine sulfoxide reductase. This enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine.	1.99309e-93
NC_012914.1\|WP_015846755.1\|5978947_5980426_-\|alpha-N-arabinofuranosidase	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	0
NC_012914.1\|WP_015846750.1\|5974433_5974982_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379237	pfam13523, Acetyltransf_8, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.63626e-24
NC_012914.1\|WP_015846764.1\|5987779_5989393_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270299	cd13581, PBP2_AlgQ_like_2, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	7.91261e-176
NC_012914.1\|WP_015846763.1\|5986876_5987758_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.6278e-57
NC_012914.1\|WP_015846749.1\|5967603_5974086_-\|S-layer-homology-domain-containing-protein	gnl\|CDD\|200477	cd11338, AmyAc_CMD, Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins. Cyclomaltodextrinase (CDase; EC3.2.1.54), neopullulanase (NPase; EC 3.2.1.135), and maltogenic amylase (MA; EC 3.2.1.133) catalyze the hydrolysis of alpha-(1,4) glycosidic linkages on a number of substrates including cyclomaltodextrins (CDs), pullulan, and starch. These enzymes hydrolyze CDs and starch to maltose and pullulan to panose by cleavage of alpha-1,4 glycosidic bonds whereas alpha-amylases essentially lack activity on CDs and pullulan. They also catalyze transglycosylation of oligosaccharides to the C3-, C4- or C6-hydroxyl groups of various acceptor sugar molecules. Since these proteins are nearly indistinguishable from each other, they are referred to as cyclomaltodextrinases (CMDs). The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	2.13152e-138
NC_012914.1\|WP_015846760.1\|5983658_5984618_-\|carbohydrate-kinase	gnl\|CDD\|238572	cd01167, bac_FRK, Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.	3.79657e-102
NC_012914.1\|WP_015846751.1\|5974994_5975834_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.6068e-26
NC_012914.1\|WP_041614676.1\|5962449_5963109_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	3.24809e-118
NC_012914.1\|WP_041613645.1\|5981831_5982650_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	8.26656e-25
NC_012914.1\|WP_015846746.1\|5963857_5964847_-\|acryloyl-CoA-reductase	gnl\|CDD\|176249	cd08289, MDR_yhfp_like, Yhfp putative quinone oxidoreductases. yhfp putative quinone oxidoreductases (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
NC_012914.1\|WP_015846752.1\|5975956_5977030_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	3.67806e-35
NC_012914.1\|WP_015846748.1\|5965718_5966615_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.80064e-46
NC_012914.1\|WP_049790082.1\|5985862_5986798_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	3.28704e-124
NC_012914.1\|WP_041613643.1\|5981068_5981848_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.28406e-24
NC_012914.1\|WP_015846753.1\|5977041_5978199_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.10263e-71

>NC_012914.1|WP_015846753.1|5977041_5978199_+|Gfo/Idh/MocA-family-oxidoreductase
MLKIAIIGSGAISRAHIDAYQKFSERCRIVAVTDIYIDKAESRINQCGLTEARAYSDYKELLGQDIDLVSVCTPPYTHAEIGVEFLKAGKHVLIEKPMASSLEECDAMNRAAEESGKLLSVVAQNRFRTPMMKLKSVLDSGLIGPVVHSQIDSFWWRGHSYYDLWWRGTWEKEGGGCTLNHAVHHIDALLWMMGRPTELQAFMSNTSHDNAEVEDLSIAMLKFVGGGLGQITSSVVHHGEEQQLIFQGKQARISAPWKLVTSSSMDNGFPTPNTALSAEIQAYYDNLPEVAYEGHLGQIDNVLSAIEGGESLLIDGHSGRATLELILGIYKSASTGEKVTFPLTADDPFYTRQGIQDNVPHFYEKGASVENFQDRAITTGSNLRG
>NC_012914.1|WP_015846752.1|5975956_5977030_+|Gfo/Idh/MocA-family-oxidoreductase
MNKSDGMNYAPQGKPNPVVMPGEFQFAAIALDHGHVYGMCNGLIEAGGELVYVYDPDPEKAARFVKAYPQVKVAASEEEIFADSRIQLVASAAITSERCALGLRVMQAGKDYFTDKAPLTTLEQLEEAKRVSAETGRKYMVYYGERLHNEGALFAGQLIEQGAIGRVVQVMGWGPHRTNAKSRPEWFFEREKYGGIICDIGSHQIEQFLSYTGAKDAQVVQSRIANYHHKDYPELEDYGDVMLTGDNGAAAYFRVDWLTPDGLSTWGDGRTLILGTDGYIEVRKYVDLAKSPEGDQVYMANGEGEFHFSVRGQVGYPFFGQLILDCIHRTENAMTQEHAFKVAELSVLAQNLAVRME
>NC_012914.1|WP_015846751.1|5974994_5975834_-|AraC-family-transcriptional-regulator
MVQAKKWFEYEYRRTSRDYFREVFHAHSQMELTYVHEGRGLLIIDGKSYSIEPNTLLVFPPFQMHRIQIQVTEAEPFIRSVLLFEPAVLHGYLNDFPSLKSFFQRLMLQQANVHPVNAMPENEPFVALLRQFSITMGGKREADFEENMGVFLLSLVHQLKQSPDGESAYLKKHNLHVEEIIGWIEKHYMDPFRLEDLAGELHLSPYHVAHLFKESTGTTIVAYTQATRIRHACSLLRKTTLPLSEIGYRVGIANPSYFSKIFRQIMGVAPLTYRQHLIK
>NC_012914.1|WP_015846750.1|5974433_5974982_-|GNAT-family-N-acetyltransferase
MILYQGKESGLRMLEPEDAGLLIRWLSDPAVLEYYEGRDRPYDAAMVQKHFYEDREEIVPCIIQYNGVDIGYLQFYEIEEEEREFYGLWDEAGSIYGMDQFIGEPDYWNRGIGSELIRETVQYVVKERGARKIVMDPQTWNARALRVYEKCCFKKVKLLEKREWHEGQYRDCWLIAYDAVKA
>NC_012914.1|WP_015846749.1|5967603_5974086_-|S-layer-homology-domain-containing-protein
MMKHVRNRNQTRVWSLLLAIMMVIQVVGLMPKQVQASAVSGTYAEAGTIHFVLPKSSVSITAKGDFNSWGDPAVTLADEDGDGTYTAEVTGDAPNKAYGYKFLVNGNWLDDPNLSVTSDENSKIHLSYTPHFKVAGSFDTNAFADQHEMALHEGNYTFAAESLADGTYTYKFISAADGLPSIWFQDPTNSETSNGNSKILVGQPPANAPTADVFANQPGGSAKWVVAGSFQGWNNASADTLMSHLVGEFYAYSTVLDPGHYEFKLVRQGTWDGYSDNGNNFAFDLAAQSKVNIYVNDELAKVRISVPGASGIPQYAPVLGAAEWPRLVGDIQAVYGESTWAPDQAKQLFVDYNFDGSVYKLQRTVPAGRYEMKVVQGDNWSANNYGSGNDNFILTTLDPADITFSTVPAERTLVTNYKPADSQFDGMIKRDKLLFDSRSVTYKKPFGAIKEGTEDVTLRIATEAGDAQVVRVELSNPEGLASAFDMHKATSFDDKDYWEVTIPGSTFQGIGVWGYKFILIDGTAKVEYGDDGSRGGTGTTADEGVLPYDLTVYDKDFTTPDWMKNAVVYQIFPDRFYDGNKDNNRAKTEDGYRGPADGDGTTAGVTSKGGYELQYFDGGVANDPTPDQVDGTWSTMPENPDRISPEQKPYFPDAKSDGVWTNEFYGGDIQGASQKLEYLKSIGVNVIYFNPVAWAGSNHKYDATDYEHLDPMFGEPVYNTPGDPSSGLDYEATRVASDRVFTEFAKKAHQMGIMLIVDGVFNHVGDDSIYFDRYEKYPEIGAYEFWAKVYDKVNDNGLALDAAKQQVIDSFTAQINPATGKHYAYPEDFDFTTWFTVSNEKVDGHYKYEGWWGYDSLPVIDAPTPAAGDTEGLAGNHEWNVQGYRDLVIGHNLTGKTDEEASAMMQEANSQRWGWMGANGWRLDVAPDVSAGTWQKFREAVKSTEGRKDSNGETIPEPIILGEEWGVATRFLLGDQFDSVMNYRFRGALQSFILGGNAQQFNDALESIREDYPAEAWEVMLNLVDSHDTIRSITKYDKPEWEEEHLAIAPEASDKALKMQALTAIFQMGYPGAPTIYYGDEVGLAGTKDPDSRRTFPWERVSESGGEYTGVGKYASLFDTYQKAGTVRDNNEVFRTGELKTAYNTGDVIAYARKTGSQGGLVVVNRGSSDVSIQADVAGFLPEGLTLKDQLGSNAEASVAGGKVTLTVKAMSGLMMTSTSELVQVPQVMNVHAASGNGQVALTWDAVAGASGYNVYRAAIEGGQLQLVGQPADASWTDTNVVNGKKYYYTVTAVTKDGESPLSVYGSATPSFPVSSVEVTKQSEEVTLGVGHKTSDIEITIDIPGLTDNAAYAGKEAPNVIGRLAFYKDGAGKATAEDTKLRYKSDTEDGRKVYWAAFEPTEAGTYRYFAKIFTDNGESYTESAEAAVLVQADSSDTEAPKAPVLAEIAVESNRVMLNWTEDSEETTVDHYEIFRKTANSGFVKIAAAVKTAVSYVDFTVSNDKAYTYKVAAVDSAYNRAYSGEQSVTPKLVMVDVKLRVHLPSYTPVKDDIYLAGDLNGWNSAGNKLTVPSGATTRDVVEYSFKMMAGKSIQYKYTRGTWATEAFTSHARLANDNVDAGNYAYSSTDTNMRLTIKNQGGNTMVVDDYVLRWVDMPMILTMPRISYGEDISYDTKEESFTLRANVPYGVDFTINDQPLADGAMDAYGNVYAENIPLQRGENRFKLHIEPSAETLAQDWYTDKGRASQATKTMDLVITRDGGDSENGNGNGNGSSGGGVTPGSSSVTVTEQQLKDAVKQAGDSKVTIAVDGKAEVLLPVGAADLLGGKPLELKQGDLTLLIPSAMLQELMKKAGGSVSSAASHIVLQLKPLDAAAERDLLKKAAAVDGSELSPASAVIEFRLALVDGNGKEAAVLSKFEEPLKLTFKLDSKADKKLTGIYYVADDGKLEYVGGTLNADGTITADIQHFSKYAALEYSKIFGDVPLTHWAWEMIRELASKHVVTGVTADRFEPERSVTRAEFAALLVRAMNLQATKPTGFTDVAASSWYADSVAAAAEAGIIKGRTATSFAPNAVIMREEMTVMLMRAYEVKSGKKLESSADGSTDGSTFTDSAAIHDWAKASIDAAVKLGFLNGKGQGKFDPQGNTTRAESAKVIYKLLGL
>NC_012914.1|WP_015846748.1|5965718_5966615_+|LysR-family-transcriptional-regulator
MNLHALRLFHTIAAAGSVTRASELLNISQPAITAQIKKFEKELMLTLFKPQGRGIALTDAGEELAVLAKRLFAVEHQIEQFAMNYNSGTIGSIRLAATYLPAHFLIPAWIAKFKQQFEQVEMNITTTNSSGALQQLLDVEVDIAIFGGMAENYPDTIHIEELFHDELWFVVAPGHRYANQQVTLPEMMKEPFVMREEGSSTRERLLSLCRTYNSAIPTISLQFNGLHEAITAVIAGYGANFVSSLVVREYVERGELARVYVEGIDLKNTIAICTRKNEPLPASAKNLVQMIRQNPYVR
>NC_012914.1|WP_085982423.1|5964918_5965590_-|O-methyltransferase
MSTLHTWEKVDAYLTEQLIQQDTILEQVLANNKQADLPAIDVAPNQGKLLSLYAQMIGAERILEIGTLGGYSTIWMARALPEHGKLITLELDPHHATVAGQNIGLAGLSQKVEVRIGEALEQLAKLDEEGAAPFDLIFIDADKPNNPHYLQWALRFSHPGTVIIGDNVVRDGEVTNRHSTDPRVQGVRKFMELLAEDPRITATAIQTVGAKGYDGFALGIVKS
>NC_012914.1|WP_015846746.1|5963857_5964847_-|acryloyl-CoA-reductase
MDHFRALVADNNGEEAPKLAIKNLTIADLPEGEVTVRVTYSSVNYKDGMVGIWGRMIKSYPHIPGIDLSGTVAESTDPRYKPGDEVIVTSYGLGVTHHGGYSELARVPASWVVPLPSGLTQREAMILGTAGFTAALSVQRLEDNGLTPEKGPVVVAGASGGVGSVAVNILAKRGYEVTASTGRLSEEAYLKELGAKHVIHRDELTESERKPIRRPLWAAAVDPVGGKTLSYLLSTLQYGGSVATSGLTGGVEVETSVYPFILRGVNWLGIDSVECPMELRRRVWERLATDLKPTMLSNTIVKEIQLEQLPEELALILQGQVRGRTIVRL
>NC_012914.1|WP_015846745.1|5963256_5963778_+|peptide-methionine-(S)-S-oxide-reductase-MsrA
MSLTHATFAGGCFWCMVTPFEELPGIHGIVSGYMGGHLANPTYEEVKKGTTGHLEVVQITFDPAVFPYERLLELFWPQIDPTDDEGQFQDRGSQYRTAIFYYNEEQKELALASKQELALSERFDKPIATEIREAETFYPAEDYHQDYHKKNPKHYKEDRAQSGRDEFIEQNWK
>NC_012914.1|WP_041614676.1|5962449_5963109_+|ABC-transporter-ATP-binding-protein
MVQMEQITKHYRMGGQRYTALQHISLEVQEGEFVAIQGPSGSGKSTLMNIMGCLDTADSGTYVLEGRRVSTMGDNQLADVRNRRIGFIFQSYNLIPTLSAYDNVELPLIYRGVPGHQRKKAVLDTLESVGLSGHLHHRPAELSGGQQQRVAIARALATNPSILLADEPTGALDSHTGKEIMALLAKLHAEGRTIILITHDQAVASCADRILYIRDGAIA
>NC_012914.1|WP_015846755.1|5978947_5980426_-|alpha-N-arabinofuranosidase
MNKAVVHADWSIGTINKNIYGHFAEHLGRCIYEGMWVGEDSEIPNTDGIRNDVIEALRNLKVPVLRWPGGCFADEYHWKDGIGPRETRKRMVNTHWGGVVENNHFGTHEFFRLCELIDAEPYICGNVGSGSIQEMSEWMEYMTFDGDSPMANLRRQNGREEPWKLKYFGVGNENWGCGGEMLPEHYADLYRNFQTYVRQYGDNKLYKIAGGASSDDYRWTDVLMSKAERFMSGLSLHHYTVPGVWADKGSATEFDENDWFVTMKKAEYMDELLTRHSTVMDRYDPSKRVGLIVDEWGTWFNVEPGTNPGFLYQQNTMRDALVAAINLHIFHKHCDRVQMTNIAQMVNVLQAVVLTEGDKILLTPTYHVLEMYNVHQDAEALAIHGQFGKVNADGKELDQVGVTASKKDGVIHVSLYNLHPSEQSEISLELRGAEGSFNCTGRLLAADAIQAHNTFEDPSKVSVKAFYEAKIENGKLSLNLPAASVVTLRLEQ
>NC_012914.1|WP_015846756.1|5980626_5980923_-|hypothetical-protein
MTITESVSKRERDGCKGCSADVRVTDDQIQRLISKIKPDACVTDKLYAKRLAACEGCASMAYDTTCMHCGCLVQVRAKLKDKGCPHPQQSVRTLWEVN
>NC_012914.1|WP_041613643.1|5981068_5981848_+|helix-turn-helix-transcriptional-regulator
MIRLDSCGYRFVHPHGISIIRPNGSGDYAFVLFKKKSEVIIRGVRILVDSDSFILFQPDTPHSYMQFELPFVNDWFHCRGEELSGLLAELNFPLDTPVPAVDPMLISRSIMELHRVQKQGGHLRDQILDTDIRALLMKLSNLHELSQHPERPGRYIRQFSELRDELYNSPQSHVTVEMLADRVHLSKSYFQHLYKDIFGCSVVTDMINGRLELAKYLLKNSTLSVSAIAASCGYEHETHFMRQFKKFVGLTPSQFKSRV
>NC_012914.1|WP_041613645.1|5981831_5982650_-|helix-turn-helix-domain-containing-protein
MNRSGVEAVEKESKNGVVTGHFLENESYCMVRPAGREDWLLVYTLEGEGFFRTPAGEKICKAGELVLLRKRVPHTYGTVKGDTWNFLWVHFNRLPELSLLPDEEVLLCPLPSSELQRRVIRIFRSLLHDSRAQGGFWEELCDNQLSALILLMAGQLADKLDYRVSQVMRILSAQMQEPLSINELAARVGLSASRLSHLFKSETGRSIVDTLNNMRLEQAVLLMLQAGRTAGEASFDVGFQSYNHFAALFRRRYGCGPAEYKRKTESTSTPET
>NC_012914.1|WP_015846759.1|5982800_5983604_+|phytanoyl-CoA-dioxygenase-family-protein
MNQSLKVLTEEQMQQFEREGYVIVKGVWSKEEIEEIQAEFDKISLTPIPGYFEPVLDGEQEDPLRRYPRVMHPHRYNDLSKNYMLHPVVLDIMHDLYGEEALAAQSMFYYKPPGSRGQALHQDNFYLKVEPGNCIAAWAAIDRCDEENGCMLLVPKTNTYEIVCPEESDSKESFTNHYVKPPKEEKPVAAIMEPGDILFFNGNLIHGSYRNKTKDRFRRAFISHYANSSAMSISHWYNPLYKADGSELSLEANPDGGPCGIETPAYH
>NC_012914.1|WP_015846760.1|5983658_5984618_-|carbohydrate-kinase
MAGNVVCIGELLIDFFCIDIDVDLEQGEQFAKKAGGAPANVSAAIARLGGSSAFVGKVGKDPFGHYLKRTLEEEKVDTSMLMLDAEVPTTLAFVSLEASGERDFVFNRGADRYVELDEIDRDRLYAASVLHFGSATALLDNPFRATYTTLLQGAAENGRPFISFDPNYRKDLWGGWLNEFTEQARYGASQADLVKVSEEELQLMTGETDPEKAVRLLHGLGANRVCVTLGRNGTLVSDGKTLVQVPSITVKSIDSTGAGDAFVGALLWQISRLEEPKGMSFEQLLLFVEFANKVGAIVCTKVGAIAALPTLEEVNRYPA
>NC_012914.1|WP_015846761.1|5984679_5985663_-|LacI-family-DNA-binding-transcriptional-regulator
MNPKISDVAEKAGVSKTTVSRVLNNRGYISQETKDAVYGAMKELNYFPNDVARSLFNKKTNLIGLILPTVNNPFFSELAFYIESICAEKGYKVLLCNSSHSRENEERYLDMLLRNQVDGIIVCSYNRGFPHYNHGKMAVVAIDHYLAPSIPVVGSDNYNGGKLATGLLLEKGCQNIIHINGPIELATPANLRRKAYEDVIRESGREPIVYENRLSFEQNRYSSLFDQIFAEHPEVDGVFASDDLIAAAFIQYVKKKGLRIPEDIKVIGYDGSEMVQAFLPELSSIQQPIKGIAQECVRILSEQIDGEADHESEEVYLPVRLMERETT
>NC_012914.1|WP_049790082.1|5985862_5986798_+|sugar-ABC-transporter-permease
MTLATISRRQKPSWIYYVFRNYTLYLFLLPAVVLTIVFKYVPMYGSIIAFKNFSPLKGIMGSEWVGLENFNRFLSSPNFYDIFMNTLKLSVYGLLLGFPVPIVLALMLNQIRGARIKKNIQLILYAPNFISVVVLTGMLFVFLSPTGVINSLVTMFTDKPISFMSDPAYFRTVYILSGIWQGAGWASIIYVAALSNVDPQLHDAATVDGASLLRRIWHIDLPTLKPVMAVLFILAAGGIMSIGYEKAFLMQTAMNTPTSEIIATYVYKVGLQSGDYAYSTAIGLFNSIINIILLVLVNAVVKRLNEGEGLY
>NC_012914.1|WP_015846763.1|5986876_5987758_+|carbohydrate-ABC-transporter-permease
MDIHISRKDRVLLVITYVLLALLVLIVLFPLLYVLLASFLNPNVLLTKGLSLNASDWSITGYEKILGNAAMLRGFLNAILYSTGFALATVVVSVFAAYPLSLEGFVGKRLFMVFFLITMFLSGGLIPTYLVVKDLNLLNTIWAIILPGAVSVYNIILARTYFAGIPKELNQAAQIDGATDQRLFFQIILPLSKPIIFVLALYAFVGQWNSYFDAMIYLDNNQLFPLQLVLRSILIQNQVDPGMISDILAQAELKKLSEMIKYSSIVVSSLPLIIMYPFFQKYFEKGVMVGSIK
>NC_012914.1|WP_015846764.1|5987779_5989393_+|ABC-transporter-substrate-binding-protein
MKKTMYSATALALSISMLAGCSSGDKGSASSKSYDLKEVSFPLQEKVTLNFMTQSSPLAPTDPNQKLVYKRLEEKTGVHINWKNFTSDSFVEKRNLAVASGDLPDAILDAAYSDYDLLKLGSDKTIIPLEDVIAKYMPNLQKVLADAPEYKAMMTAPDGHIYSFPWIEELGAGKESIHSVNDIPWINVEWLNKLGLKMPTTTEELKNVLLAFKKGDPNGNGQADEIPLSVVMNNGNEDLNFLFGSFGLGDNGDHTVVTDDGKVVFTADQDGYKDAVNYLHDLYALDLIDEESFEQDYNTFLAKGQDNRYGLYFTWDKANITGNNDKYDLMQPLAGPSGEVNVTRTNNYGFDRGRMVITSANKNIELTAKWIDQLYEPLQSVQDNWGTYGDETQQNIFKFDEAKGMLEHLPLEGAAPAELRQKTNIGGPLAILDEYYGKYTTKPDDAAWRLNIMKERLVPYMKAENNYPRIFFSLEDQKQLSTIETDLFAYVNRKRAEWIKTGKVNEEWADYLKELNRLGLEKWLEIKQNGYDNYIKS

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Crispr_ID: NC_012914_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012914_10

6745951-6746037

Orphan

Consensus_repeat	Method
TTTTTTCCCTTACAGCTACCCGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012914_10

>merge|NC_012914|10|6745951-6746037|CRISPRCasFinder
TTTTTTCCCTTACAGCTACCCGCTCCGTATCAGCCCAACTAACAACCAGCCCAATAAGTCGGTTTTTTCCTCTTACAGCTACCCGCT

>NC_012914|10|8|6745951-6746037|CRISPRCasFinder
TTTTTTCCCTTACAGCTACCCGCT	CCGTATCAGCCCAACTAACAACCAGCCCAATAAGTCGGT
TTTTTCCTCTTACAGCTACCCGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_012914.1\|WP_041614788.1\|6750208_6750595_-\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|133478
NC_012914.1\|WP_015847422.1\|6745225_6745771_-\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|223463
NC_012914.1\|WP_015847421.1\|6744573_6745158_+\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_015847411.1\|6732913_6733666_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133005
NC_012914.1\|WP_015847429.1\|6751044_6752493_-\|cardiolipin-synthase	unknown	unknown	gnl\|CDD\|211988
NC_012914.1\|WP_015847430.1\|6752646_6753963_+\|dNTP-triphosphohydrolase	unknown	unknown	gnl\|CDD\|273571
NC_012914.1\|WP_015847427.1\|6749456_6750224_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|294013
NC_012914.1\|WP_015847425.1\|6746778_6747759_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381312
NC_012914.1\|WP_041614779.1\|6733688_6734825_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340831
NC_012914.1\|WP_015847433.1\|6755240_6756173_-\|D-alanyl-D-alanine-carboxypeptidase-family-protein	unknown	unknown	gnl\|CDD\|350624
NC_012914.1\|WP_015847432.1\|6755003_6755159_+\|DUF1540-domain-containing-protein	unknown	unknown	gnl\|CDD\|377869
NC_012914.1\|WP_015847416.1\|6738429_6740574_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133005
NC_012914.1\|WP_015847414.1\|6735093_6736953_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133005
NC_012914.1\|WP_015847419.1\|6743372_6743861_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_015847415.1\|6736964_6738473_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133005
NC_012914.1\|WP_015847420.1\|6744040_6744574_+\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_015847431.1\|6753963_6754929_-\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|239113
NC_012914.1\|WP_015847418.1\|6741599_6743363_-\|S-layer-family-protein	unknown	unknown	gnl\|CDD\|380183
NC_012914.1\|WP_015847424.1\|6746182_6746668_-\|cytochrome-c-biogenesis-protein-CcdC	unknown	unknown	gnl\|CDD\|377808
NC_012914.1\|WP_015847426.1\|6747860_6749318_-\|catalase	unknown	unknown	gnl\|CDD\|163710

Protein	Function_ID	Function_description	E-value
NC_012914.1\|WP_041614788.1\|6750208_6750595_-\|transcriptional-repressor	gnl\|CDD\|133478	cd07153, Fur_like, Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators. Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.	1.32373e-40
NC_012914.1\|WP_015847422.1\|6745225_6745771_-\|glutathione-peroxidase	gnl\|CDD\|223463	COG0386, BtuE, Glutathione peroxidase [Posttranslational modification, protein turnover, chaperones].	1.26462e-86
NC_012914.1\|WP_015847411.1\|6732913_6733666_+\|glycosyltransferase	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	1.05938e-21
NC_012914.1\|WP_015847429.1\|6751044_6752493_-\|cardiolipin-synthase	gnl\|CDD\|211988	TIGR04265, bac_cardiolipin, cardiolipin synthase. This model is based on experimentally characterized bacterial cardiolipin synthases (cls) from E. coli, Staphylococcus aureus (two), and Bacillus pseudofirmus OF4. This model describes just one of several homologous but non-orthologous forms of cls. The cutoff score is set arbitrarily high to avoid false-positives. Note that there are two enzymatic activites called cardiolipin synthase. This model represents type 1, which does not rely on a CDP-linked donor, but instead does a reversible transfer of a phosphatidyl group from one phosphatidylglycerol molecule to another.	0
NC_012914.1\|WP_015847427.1\|6749456_6750224_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|294013	cd00383, trans_reg_C, DNA-binding effector domain of two-component system response regulators. Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.	5.92977e-35
NC_012914.1\|WP_015847425.1\|6746778_6747759_-\|aldo/keto-reductase	gnl\|CDD\|381312	cd19086, AKR_AKR11C1, AKR11C family of aldo-keto reductase (AKR). Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.	6.87351e-113
NC_012914.1\|WP_041614779.1\|6733688_6734825_+\|glycosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	1.88887e-38
NC_012914.1\|WP_015847433.1\|6755240_6756173_-\|D-alanyl-D-alanine-carboxypeptidase-family-protein	gnl\|CDD\|350624	cd14852, LD-carboxypeptidase, L,D-carboxypeptidase DacB and LdcB, and related proteins. This L,D-carboxypeptidase family includes LdcB LD-Carboxypeptidase from Streptococcus pneumoniae, Bacillus anthracis, and Bacillus subtilis, and L,D-carboxypeptidase DacB from Streptococcus pneumonia and Lactococcus lactis. These enzymes are active against cell-wall-derived tetrapeptides and synthetic tetrapeptides lacking the sugar moiety but are inactive against tetrapeptides terminating in L-alanine. L,D-carboxypeptidase DacB plays a key role in the remodeling of S. pneumoniae peptidoglycan during cell division. It adopts a zinc-dependent carboxypeptidase fold and acts as an L,D-carboxypeptidase towards the tetrapeptide L-Ala-D-iGln-L-Lys-D-Ala of the peptidoglycan stem. This family also includes vanY D-Ala-D-Ala carboxypeptidase which is vancomycin-inducible and penicillin-resistant. VanY hydrolyzes depsipeptide- and D-alanyl-D-alanine-containing peptidoglycan precursors; it is insensitive to beta-lactams. All these enzymes belong to the MEROPS family M15 subfamily B.	2.0788e-81
NC_012914.1\|WP_015847432.1\|6755003_6755159_+\|DUF1540-domain-containing-protein	gnl\|CDD\|377869	pfam07561, DUF1540, Domain of Unknown Function (DUF1540). This family has four conserved cysteines, which is suggestive of a metal binding function.	6.40881e-09
NC_012914.1\|WP_015847416.1\|6738429_6740574_-\|glycosyltransferase	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	5.98066e-44
NC_012914.1\|WP_015847414.1\|6735093_6736953_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	1.38699e-43
NC_012914.1\|WP_015847418.1\|6741599_6743363_-\|S-layer-family-protein	gnl\|CDD\|380183	NF033176, auto_AIDA-I, autotransporter adhesin AIDA-I.	0.00056187
NC_012914.1\|WP_015847415.1\|6736964_6738473_-\|glycosyltransferase	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	8.89872e-49
NC_012914.1\|WP_015847431.1\|6753963_6754929_-\|nucleoside-hydrolase	gnl\|CDD\|239113	cd02647, nuc_hydro_TvIAG, nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. Nucleoside hydrolases vary in their substrate specificity. This group contains eukaryotic and bacterial proteins similar to the purine specific inosine-adenosine-guanosine-preferring nucleoside hydrolase (IAG-NH) from T. vivax. T. vivax IAG-NH is of the order of a thousand to ten thousand fold more specific towards the naturally occurring purine nucleosides, than towards the pyrimidine nucleosides. .	2.34392e-120
NC_012914.1\|WP_015847430.1\|6752646_6753963_+\|dNTP-triphosphohydrolase	gnl\|CDD\|273571	TIGR01353, dGTP_triPase, deoxyguanosinetriphosphate triphosphohydrolase, putative. dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions].	8.54585e-90
NC_012914.1\|WP_015847424.1\|6746182_6746668_-\|cytochrome-c-biogenesis-protein-CcdC	gnl\|CDD\|377808	pfam07301, DUF1453, Protein of unknown function (DUF1453). This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown. Members of this family seem to be found exclusively in the Order Bacillales.	8.60958e-54
NC_012914.1\|WP_015847426.1\|6747860_6749318_-\|catalase	gnl\|CDD\|163710	cd08154, catalase_clade_1, Clade 1 of the heme-binding enzyme catalase. Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes, which is involved in the protection of cells from the toxic effects of peroxides. It catalyzes the conversion of hydrogen peroxide to water and molecular oxygen. Catalases also utilize hydrogen peroxide to oxidize various substrates such as alcohol or phenols. Clade 1 catalases are found in bacteria, algae, and plants; they have a relatively small subunit size of 55 to 69 kDa, and bind a protoheme IX (heme b) group buried deep inside the structure. They appear to form tetramers. In eukaryotic cells, catalases are located in peroxisomes.	0

>NC_012914.1|WP_015847422.1|6745225_6745771_-|glutathione-peroxidase
MSVYSFEADTIRGQRVSLEDYKGKVLVIVNTASKCGFTPQYSDLQKVYEQFKEQGLEILGFPSNQFGEQEPGSNSDVQEFCQINYGVSFPLFAKTDVREESAHPLFKYLTEQAPFHGFDTSEPSGKMLHTFLSEKLPHYLEGNDVKWNFTKFLVDREGNVIKRFESTDEPLNMVEDIQKLL
>NC_012914.1|WP_015847421.1|6744573_6745158_+|hypothetical-protein
MPNNPIFDGSNGPLYGAAANSYTQPGSEIPVQSGTSVQAGSSFSISASNSLSLGLLGGSVNISIRIANPSGSGKTAYLGQIIGYTNISLSLLSSFSAQVTVYSGGTVASPTTVTPVNFNLGSGTASVASVTTSINAVTGGTAFILYPLQPGPFSFSVGGGVSVPPGQTLTVNVVGSLTVLGLMGVGAEVIWWEA
>NC_012914.1|WP_015847420.1|6744040_6744574_+|hypothetical-protein
MTNYSVFNSENNPLYILLNNRYSSPAIVAPPEEDAAASGRFFMVTSASTAVGAGSNLLIQITNPNGSGRSLYVSKISGGVSAAATVNLYSGGTVTGGTTPTPFNMQLGNATTSVATARVTTGSVSGSPTLFYTTLLAAGMFEVAFAGGLIVAPNRSVTISVGTGAITAAANISWWEF
>NC_012914.1|WP_015847419.1|6743372_6743861_-|hypothetical-protein
MGKTAGCKHRRPRRCRKKPLKPKKRCIPRRRVCRRGKDGNCCQSFRSIEYEEAATSDEFVPMPKQDTSSDLVLSYSVLNRGGNAAVVRLEVGPNGVDFASDYESVVEPGGMIIMTPSRFLHFTRLSIRSQQPGASTLIQVYFQAQRTQMTSVHEFHFLRENR
>NC_012914.1|WP_015847418.1|6741599_6743363_-|S-layer-family-protein
MPNFSTFNPNPDNLRTLIFGKDSTDTARPLTVDSSGNLVTVMLDGTISSILGVTITAGTVAISGGTVGVTGTVAVSGGTVDATLAGGTLSALLGATITGGTISAVLGTTITAGTVAISGGTVEVSGGTVAVSGATVTGGTVDAVLGATITAGTINAVLGTTITAGTVAISGGTVAVSGGTFELSGGTVAVSGATVTGGTLDAVLGATITAGTLDALLGATITAGTIDAVLGATITAGTLNALLGATITGGTINAVLGTTITAGTVAISGGTVAVSGGTFEIAGGTVAVSGATITAGTLDALLGATITAGTLDALLGATITAGTLDALLGATITAGTLDAVLGATITAGTITAVLGTTITAGTVAISGGTVALSGGTVAVSGATITAGTLDALLGATITAGTITAVLGTTITAGTVAISGGTVALSGGTVAVSGATITAGTLDALLGATITAGTLDALLGATITAGTLDAVLGATITAGTITAVLGTTITAGTVAISGGTVALSGGTVAVSGATITAGTLDALLGATITAGTLDALLGATITAGTLDAVLGATITAGTITAVLGTTITAGTLDALLGATITAAHWMQF
>NC_012914.1|WP_015847416.1|6738429_6740574_-|glycosyltransferase
MLLGVHIIVRNEEDMLPECLDSIRGIADELIVVDTGSTDGTVDIALRYGARVIKAEWKDNFSSARNLALEHARTIWVLVLDADERLKGDSQSLRQGLRKAASPAYRLRMEHLLDGSNTGRSMTSEAVRLFRADRGYVYHGEIHEQLVRVRETEDGAVLKDVDGPLCAGDSHIAHIGYMPDVLQRKSKAERNLRVISRQLTKRPNDPFCLYNYGVTLCQLGKAEEAAVAFDKALGYTPLSAPYRPTLVRDYATTLLALSRNGEAAELLRGETLRYPDYPDLYLLQGNSLSAAGMLLEAKAAYEAAIEAGSRPHSYISENGAGSYQAQLRLASVLQRTGEAEAALLAYEALLGAKPGWEEALLALADYLQQLGVPDQEIRQKLSSFTGNDVADPHKLMARVLSRIGANSMALPLWREVVQSTSVSTAGAPMPEQLPWCDIRGFADCLIGTGQYAEAASQIRSWLQAAQPSADAEPSYEILQLGMDWALCRWNDGLQISREELAAVLGGGRLAHEAEHLNGWLPAAQGPQNKIAKEQELAAAARWLDTAVSRGMLRLAHRLAGGFYGLRPYFETLLYDHGYVDAAAEQMLDRFEKEGRLTGEQSFRLGELLYLKKLHNEALSLFDSSAESDKSGVYAERARLGAAAACLQLAIEALQPDEYSGTRNWDGSWSEPDRMKLQEALLRVEWMSWQTSWNGRQRRRVNGGTAEADFLMYDR
>NC_012914.1|WP_015847415.1|6736964_6738473_-|glycosyltransferase
MAEQRKRISLCMIVKNEEKHLPGCLDSVLGIADEIIVVDTGSTDETIAIAERYGAQVIRSGWEHDFAKARNKGVERASGEWILFLDADEQLDAATKPQLLEYAGHAELSALLLQIRNQVGPDHDQGSTIHPVLRMFRNDPAHRFEGRIHEQISFSILRKNPSARFHLTDVIIHHYGYRTQVVAEKNKLQRNMELLELALAEDPDNTFHRYNIGVEYLRNNRAEEALEAFRIAKRSAGFEQLSYAHLVLKYESLSLQLLGRWEEAAAPAKEGSAIFPDYTDLWHYIALCSASTGRFKNAMEAAEKALELGAAPARYHTEDGMGTFRTAYLQGRIYEALHDEQGVEQAYMKALRFKPSLLPPLFRLCKYMRTAGREGQLAAWMARRISCPDEAAMLKLAGVMVASGCPASAAAYLEWQGELYKEPGLRHSLAVQANALRDGDYSGLPFAGWLGKDEAEDTLSSAVYWRARAEQYLERVQQSKERPVERQAVQSIRMLLPGFEGW
>NC_012914.1|WP_015847414.1|6735093_6736953_-|glycosyltransferase-family-2-protein
MEGQLPITLCMIVRDEELFLPDCLAAAAPYCSEIIVADTGSTDRSADIAEAYGAIVRRVVWQDDFALARNAAIEQASQPWILVLDADERLLPLPVKEWSQLLSAEQCYGYLIRIRSRVDGRSGEEEVSDAVCRLFRNDPRIRFSGAIHEEAATAVSACGEEALRFAPVEVLHEGYRHAVMARRGKKERNKRILLAALNREPENPVLRYAMGTEYFTYGDWERAAEWLEPMVNGKEAGDDAGYLSDIWLKLVHALRALGRLEDAERYARSGLTRYADFPDLHEAYAAVLMEMDRPGEAGSVLERACLAGARSAHYSSAAGSGSYRTLLAAGYAAERGYDWNRAAEAYAAALEANPGYRPAWERLVMLGTLDADHRTHWLAAANRAAATGDHRLCRFMLELLADAGLQLEPEVSSRLMTGLAVGEAFWSGLLAAQQGDPAAARQRWAQLPDAYPGRGEYLAALAWADGGRAEPPPAGIAHALLRVRAWPAWLRLCPAAPPPLAAPVPAAPLQWCALLGAAPPVPALAAAQRLRAAAQPGAPARLAAGVLHFAAGDMPAAAEQFAAAREAAAQPWVSRAAAAGLAAALAARARSAAQVPVLAAPLLCEQELMLRITSVLYSL
>NC_012914.1|WP_041614779.1|6733688_6734825_+|glycosyltransferase
MKTVTILTHSYLNAYGQDYSRVFGGGLERYVDLLCRAIKELGLNPVVYQMTYYEAFDTVHEGVRVKGWPFEANKITEAFERMAESAEGLLIYASCIWHPIRYRPGSIGICHGINWDTPSIAAGTKAAITRHINQALRQLDRVVSVDSHFQTYCRAVCEYEDPAVITLLPNPVDTLRFVPRPGGVSPSAKEVRVLFPRRLSFERGLVTMMLSADELLCRYPALTVEFAGELIDGSMMAAAFYLWKEAHPHRDRIIHRTYTFETIQTAYHQADIAVIPTLFSEGTSLSCLEAMSCGLPVVATNVGGLNDLIINGVNGRLITTSAEAVTSAVSELIEQPRLRRRLGIAARRAALAFDQTRWLAEWKAIITAQLAKGDGESR
>NC_012914.1|WP_015847411.1|6732913_6733666_+|glycosyltransferase
MSSGLGKGGRKITDNKLTAIMQVRNEAGRYLEAALADLSGFADEIVIVDDGSTDDTPELAASFEKVVKLVRNKDSLFHKEWLLREQLWRAAEETSPDWLLAVDADEFYEDDAKAAMRQLINQDDYDTVSFRMYDFWDSVTHYREDDWWNLHQRPMMTLVRYLPGFHYAYPKRAHHATRLPFTYNALPSLDTDLRIKHYGWAGSAEDRRAKYDRYMKLDPQGHWGNLGHYASILDPNPRLIRWQERERRDG
>NC_012914.1|WP_015847424.1|6746182_6746668_-|cytochrome-c-biogenesis-protein-CcdC
MLSANTHLIQVASIVFSVCAGLTLIVLRMRAGKQPTNLRKIIAPPLGMSTGFMMFAFPVTHIHWLWGLSAFGTGLLIFSFPLIVTTRLERVESDIFVRRSKAFIFIMLTLLAIRLALHSVVEQYMSIPQTGALFYLLAFGMILPWRFAMVGDYMRLQKAEM
>NC_012914.1|WP_015847425.1|6746778_6747759_-|aldo/keto-reductase
MQYRGLGSSELKVSEISFGTWAIGGAWGNVNDKESLMALEAAIDKGVNFFDTADVYGDGHSEQLLAQAAKGREDEIYIATKFCRAGDIHDPATYSEASVRAYCEASLKRLERERIDLYQIHCPPMSILKNGSVFEVLDKLQQEGKIRHYGVSVESVEEGLFCLEQPNVRALQVIYNIFRQKPLELLNEAHRRGVGILVRLPLASGLLTGKFTASSTFEADDHRRFNENGEAFNVGETFAGLGFAKGVELADQLRWMEEGRGNMTRASLRWLLDHEAVTCVIPGFRNVRQVEDNLAALDVPSFTAEDRERLAAFYKEQVHPFIRGSY
>NC_012914.1|WP_015847426.1|6747860_6749318_-|catalase
MINRLTTNQGKPVGDNQNSRTAGQRGPTLLEDYHLIEKIAHFDRERIPERVVHARGAGAYGVFRAASSMSAHTKAAFLREAGKETDVFVRFSTVIHGTGSPETARDPRGFAVKFYTEEGNLDIVGNHLPVFFIRDAIKFPDMVHSLKPSPRTNIQEPERYWDFMTLSPESTHMLTWVFSDAGTPASYREMDGFGVHAFKWINDEGNVTYVKYHWKSKQGVRNFTAAEASEMQGKDFNHATRDLYDSIELGQYPEWDLHVQLMPVEHLDRYSFDPLDPTKIWPEDMYPLQLVGTMRLNRNPDNYFAEVEQSAFAPSAVVPGIEPSEDKLLQGRLFSYPDAQRYRLGANYLHIPVNCPYAPVRNHQQGGAMTMKADPSTVNYEPNSSSESPREVSEYKDGDAPLHGYAGRQKIDKTDDFTQAGERYLSLPPEQRDNLVSNLVNDLKHASENVQLRAVCNFFRANVEFGIRLSKGLGVDISAYMQHQR
>NC_012914.1|WP_015847427.1|6749456_6750224_-|winged-helix-turn-helix-transcriptional-regulator
MRQQVEDNRMEGPPSSESMEGKACSLTKRIMTVSPFPERMNSLLHLLTAECFDLFTLHDLNKAFVSSLQPELIIYDATPHPLIPDAIDALHAAMTQTSPINGASLLYLVHEDARIMAAAIPKHAELLAWPSNPQEALNQINRMLGEWKAPDLSSYRFKDLTVDLKKMAVFRGGERIELTKTEYDLLLMFLTSDGAVLTREAMFDAVWGSQYFGGSNVVDVHIKTLRRKLKDSAVAPHYIATVRGVGYRLVEERGN
>NC_012914.1|WP_041614788.1|6750208_6750595_-|transcriptional-repressor
MTKINLTVQRKTILEAIQESNDHPTAADIIERLRDKGVSFAYGTVYNSLRYLTDAGLIRELKLGEAVSRYDARMDDHHHIMCKQCGRVEEVLTELPEEWLKKIAAETKFKVQDAHVVLEGVCELCASK
>NC_012914.1|WP_015847429.1|6751044_6752493_-|cardiolipin-synthase
MNVLQDVSTVFIVLNILLALTVIFLERKDARSTWAWLMVLYFLPGVGFVLYLILGQRLRKRKLNKMLLESQRIIEDSIEAQKLQLEERHIIFNDPATINYQSMIHMNLVGSYSLYTQNNAVQIFTTGKSKFDALLRDIESAQHHIHLVYYIVRDDKLGNRLIQALVEKAKQGVQVRFLYDHIGSKGLPRKFFKELREAGGQAAAFFPSRIPYLNLKINFRNHRKLVIVDGRIGYIGGFNIGDEYMGRDKYFGEWRDTHLRLEGRAVLQMQAQFLMDWNLASAGMVELDYHYFPRHFQAVGTIGMQVVASGPDSESQQIKDAYIKMIYFAKKSICLQTPYFVPDESLMTALKTAAMSGIEVKVMLPGKPDHFFVYWATHSYLNELLAAGGKCYIYERGFLHAKTLVIDGQLASVGTANIDNRSFKLNFEMNAFIYDSATAGELERLFDLDLQDCHELTFEDYLKRPLMNKFKESIARLLSPIL
>NC_012914.1|WP_015847430.1|6752646_6753963_+|dNTP-triphosphohydrolase
MDLRKFRLDEPALGTFSEERDEYERDYARLIQSPAFRRLQGKSQVFGAGSGDYYRTRLTHSLEVSQIAREVARRLGKQYPFLSKKEHPGLIMDPSVVEIAALAHDLGHPPFGHKGEEVLNRLLLEEHGLAYEGNAQNFRILMFLEKRAGSGSGLDLTAAVLLAVNKYPYSLDEPGRLKGLYSSEWHAINHIRQQWAMPVGSSTLEAQLMDLCDDIAYSTHDIEDGIRAGKIQMNRTFFEDQRLIDNLVQEIVEDQGNMDVGWDQVDIPAMVGRVLAAYLLQWEELYALYDHESSRTRREMKARWVSVFAGRVGIIEDPVKGWKKVTFVLDGQQDIDLLRTMEILKKLAWVTLIKDFRVQRLQMRSEIMIRRLWDSFKRPEQGRLILPPDWVASFEQHKHNWTWARFIADYISGMTDAYAEKVYAELYASKSGSIYEMD
>NC_012914.1|WP_015847431.1|6753963_6754929_-|nucleoside-hydrolase
MGKKLYFNHDAGVDDLVSLFLVLQMKDVELVGVSVIPADGYLEPGMAASRKIIDRFGAPGTSGKVEVARSNSRGSNPFPAEWRMHTFFVDALPILNEPGVIHTPEAELPAHKHMIRQLLASDEPVTLLFTGPLTDLARALDEAPEIEKKIDKLVWMGGTFNEQGNVQEPEHDGTAEWNAFWDPEAVDRVWNSGIQIELVALESTNKVPLTVPVRNRWASLRKHAGLDFVGQCYAACPPLVFMETNSTYYLWDVLTTAVVGDPSLVEMKTVHSTVIARGPSQGRTVETADGRPVSLVYDVEPERFFDYITSLSQNAVLNPAE
>NC_012914.1|WP_015847432.1|6755003_6755159_+|DUF1540-domain-containing-protein
MAKDVLCEVNSCKYWAAGNNCAATSIYVVNNRSKQASNSDETDCKTFEPKI
>NC_012914.1|WP_015847433.1|6755240_6756173_-|D-alanyl-D-alanine-carboxypeptidase-family-protein
MRRNVQRRKRRGLAFLAVCVVAIAVILFIRYENLTAQAPEETAANSQNSEQPSPTASDEPAVSDEPTDAPTDAPSDKPSDTPSNTPSEKPSDKPTDTPADKPAIATAGEEDGYAVVAQPASVAVLVDKQYKLPDNYEPKDLVYPDVRFTFSEKIDKRKMRKEAAGALEDLFAGAEKDGIYLAGVSAYRSQATQKTLFNNYVKKDGMEKALTYSAFPGTSEHQTGLAIDVSGSDGKCAATDCFGGTPEAEWLADHASEYGFIIRYPEGKDAITGYKYEPWHLRYVGKELAKEINDKGLTLEEYYNAVPVTK

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Crispr_ID: NC_012914_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012914_11

6891262-6891340

Orphan

Consensus_repeat	Method
GCTACATTGGATTCTCTACAATAAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012914_11

>merge|NC_012914|11|6891262-6891340|CRISPRCasFinder
GCTACATTGGATTCTCTACAATAAAAATGGACTAAAATGGAGGGTGTCGGAGGCTACATTGGATTCTCTACAGTAAAAA

>NC_012914|11|9|6891262-6891340|CRISPRCasFinder
GCTACATTGGATTCTCTACAATAAAAA	TGGACTAAAATGGAGGGTGTCGGAG
GCTACATTGGATTCTCTACAGTAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012914.1\|WP_015847551.1\|6886087_6886732_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_012914.1\|WP_015847549.1\|6884412_6884844_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133383
NC_012914.1\|WP_015847557.1\|6891454_6892156_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_015847564.1\|6899111_6899969_-\|D-Ala-D-Ala-carboxypeptidase-VanY	unknown	unknown	gnl\|CDD\|350624
NC_012914.1\|WP_015847560.1\|6894202_6895021_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187632
NC_012914.1\|WP_041614821.1\|6885054_6886023_-\|quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|176189
NC_012914.1\|WP_015847547.1\|6881846_6882995_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_041614824.1\|6901134_6901845_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_012914.1\|WP_015847548.1\|6883156_6884410_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NC_012914.1\|WP_015847553.1\|6887887_6888670_+\|phosphonate-ABC-transporter,-permease-protein-PhnE	unknown	unknown	gnl\|CDD\|273441
NC_012914.1\|WP_015847562.1\|6896097_6897150_-\|hypothetical-protein	unknown	unknown	unknown
NC_012914.1\|WP_083778285.1\|6888729_6889464_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|273441
NC_012914.1\|WP_015847558.1\|6892171_6893173_-\|phosphotransferase	unknown	unknown	gnl\|CDD\|270702
NC_012914.1\|WP_015847552.1\|6886906_6887806_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270232
NC_012914.1\|WP_015847565.1\|6900053_6901151_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_012914.1\|WP_015847555.1\|6889554_6890343_+\|phosphonate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213223
NC_012914.1\|WP_015847556.1\|6890379_6891153_+\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NC_012914.1\|WP_015847561.1\|6895136_6895718_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_012914.1\|WP_015847563.1\|6897146_6898922_-\|HSP90-family-protein	unknown	unknown	gnl\|CDD\|237603
NC_012914.1\|WP_015847559.1\|6893320_6894172_+\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276

Protein	Function_ID	Function_description	E-value
NC_012914.1\|WP_015847551.1\|6886087_6886732_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.95339e-36
NC_012914.1\|WP_015847549.1\|6884412_6884844_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133383	cd01108, HTH_CueR, Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators. Helix-turn-helix (HTH) transcription regulators CueR and ActP, copper efflux regulators. In Bacillus subtilis, copper induced CueR regulates the copZA operon, preventing copper toxicity. In Rhizobium leguminosarum, ActP controls copper homeostasis; it detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. These proteins are comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain winged HTH motifs that mediate DNA binding, while the C-terminal domains have two conserved cysteines that define a monovalent copper ion binding site. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	9.74861e-24
NC_012914.1\|WP_015847560.1\|6894202_6895021_-\|SDR-family-oxidoreductase	gnl\|CDD\|187632	cd05374, 17beta-HSD-like_SDR_c, 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. 17beta-hydroxysteroid dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.84299e-74
NC_012914.1\|WP_041614821.1\|6885054_6886023_-\|quinone-oxidoreductase	gnl\|CDD\|176189	cd05286, QOR2, Quinone oxidoreductase (QOR). Quinone oxidoreductase (QOR) and 2-haloacrylate reductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. 2-haloacrylate reductase, a member of this subgroup, catalyzes the NADPH-dependent reduction of a carbon-carbon double bond in organohalogen compounds. Although similar to QOR, Burkholderia 2-haloacrylate reductase does not act on the quinones 1,4-benzoquinone and 1,4-naphthoquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.12615e-151
NC_012914.1\|WP_015847565.1\|6900053_6901151_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.09661e-48
NC_012914.1\|WP_041614824.1\|6901134_6901845_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	5.43949e-91
NC_012914.1\|WP_015847558.1\|6892171_6893173_-\|phosphotransferase	gnl\|CDD\|270702	cd05153, HomoserineK_II, Type II Homoserine Kinase. This subfamily is composed of unusual homoserine kinases, from a subset of bacteria, which have a Protein Kinase fold. These proteins do not bear any similarity to the GHMP family homoserine kinases present in most bacteria and eukaryotes. Homoserine kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to L-homoserine producing L-homoserine phosphate, an intermediate in the production of the amino acids threonine, methionine, and isoleucine. The Type II homoserine kinase subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.43787e-35
NC_012914.1\|WP_015847553.1\|6887887_6888670_+\|phosphonate-ABC-transporter,-permease-protein-PhnE	gnl\|CDD\|273441	TIGR01097, PhnE, phosphonate ABC transporter, permease protein PhnE. Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions].	2.7016e-76
NC_012914.1\|WP_015847548.1\|6883156_6884410_-\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.29282e-99
NC_012914.1\|WP_083778285.1\|6888729_6889464_+\|ABC-transporter-permease-subunit	gnl\|CDD\|273441	TIGR01097, PhnE, phosphonate ABC transporter, permease protein PhnE. Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions].	2.53673e-51
NC_012914.1\|WP_015847564.1\|6899111_6899969_-\|D-Ala-D-Ala-carboxypeptidase-VanY	gnl\|CDD\|350624	cd14852, LD-carboxypeptidase, L,D-carboxypeptidase DacB and LdcB, and related proteins. This L,D-carboxypeptidase family includes LdcB LD-Carboxypeptidase from Streptococcus pneumoniae, Bacillus anthracis, and Bacillus subtilis, and L,D-carboxypeptidase DacB from Streptococcus pneumonia and Lactococcus lactis. These enzymes are active against cell-wall-derived tetrapeptides and synthetic tetrapeptides lacking the sugar moiety but are inactive against tetrapeptides terminating in L-alanine. L,D-carboxypeptidase DacB plays a key role in the remodeling of S. pneumoniae peptidoglycan during cell division. It adopts a zinc-dependent carboxypeptidase fold and acts as an L,D-carboxypeptidase towards the tetrapeptide L-Ala-D-iGln-L-Lys-D-Ala of the peptidoglycan stem. This family also includes vanY D-Ala-D-Ala carboxypeptidase which is vancomycin-inducible and penicillin-resistant. VanY hydrolyzes depsipeptide- and D-alanyl-D-alanine-containing peptidoglycan precursors; it is insensitive to beta-lactams. All these enzymes belong to the MEROPS family M15 subfamily B.	2.09901e-55
NC_012914.1\|WP_015847552.1\|6886906_6887806_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270232	cd01071, PBP2_PhnD_like, Substrate binding domain of phosphonate uptake system-like, a member of the type 2 periplasmic-binding fold superfamily. This family includes alkylphosphonate binding domain PhnD. These domains are found in PhnD-like proteins that are predicted to function as initial receptors in hypophosphite, phosphonate, or phosphate ABC transport in archaea and eubacteria. PhnD is the periplasmic binding component of an ABC-type phosphonate uptake system (PhnCDE) that recognizes and binds phosphonate. PhnD belongs to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. The PBP2 have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.23085e-87
NC_012914.1\|WP_015847555.1\|6889554_6890343_+\|phosphonate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213223	cd03256, ABC_PhnC_transporter, ATP-binding cassette domain of the binding protein-dependent phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	7.6298e-135
NC_012914.1\|WP_015847556.1\|6890379_6891153_+\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	5.33917e-77
NC_012914.1\|WP_015847561.1\|6895136_6895718_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.01158e-12
NC_012914.1\|WP_015847563.1\|6897146_6898922_-\|HSP90-family-protein	gnl\|CDD\|237603	PRK14083, PRK14083, HSP90 family protein; Provisional.	0
NC_012914.1\|WP_015847559.1\|6893320_6894172_+\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	8.95572e-18

>NC_012914.1|WP_015847556.1|6890379_6891153_+|tyrosine-protein-phosphatase
MTTNQFERIVPMERVLNFRDMGGYKTNDGREVKPGLIFRSADLSAMTEKDIALLRELNITAIFDYRDDHESEKQPDPAIPSVKNIRVPAINNPAMTSADFEKDMVKLMDQMSLEQMTKMYGVMPLNNPSFKALIQLFEEQEGAAFLHHCMGGRDRTGVGAALILTTLGVDRGTIIADYLISNETLAPMNDQLRERMKPHLPEEKIEELMEKMRLREEFLVAVFNAIEESYGTFEAYLEQEFGINAERRAKLQSHYLA
>NC_012914.1|WP_015847555.1|6889554_6890343_+|phosphonate-ABC-transporter-ATP-binding-protein
MKPMLQINNLKKRYGSSTLALNGIDLEVYPNEFIAVIGPSGAGKSTLLRCINRLIDPTEGSISFQGQEIVGAGKKQLRQIRSHIGMIFQHYNLVDRLSVLENVLHGRLGQMSAFNGVFSRYSEADKLQAITLLEKLGLAEQVYKRADELSGGQKQRVGICRALAQKPSLILADEPIASLDPNSSKIVMDSLHTNCMEQGIACLVNLHQVEVAKQYATRIVGIKGGKVVFDGKPEELTERMTQHIYEGKEHQMFQQHNAMQAV
>NC_012914.1|WP_083778285.1|6888729_6889464_+|ABC-transporter-permease-subunit
MLLLFIPCFFYLKLDLNQFKQGLHQIPHIASMMMQMSFSEFPALMDGLLTSLIIAFLTVVISVVISFFLAFVIATNTAPIPFLAKLIRAIIVIVRTIPVTVWVLLAVASIGFGSMAGVLGLIFPTVAFLTRVFSDQIDEAGKDIIEAVKAVGGGWWNLVFNGVTPQLMTAFLASIAFNFEITVAETVILGIVGAGGIGVLLQEYISFYDFKPLTLGILIVFITLFLLEMTTNLIRHSLSGRSHK
>NC_012914.1|WP_015847553.1|6887887_6888670_+|phosphonate-ABC-transporter,-permease-protein-PhnE
MQTAAAVKQKKLKRNVSLAFFAAAVVFSLWYIKFSFSEFVSGIPIFLRFLFTDFLPPKASDLPSYLQPVLDTLAYGVVATVLASIIGLLFGFLMARQTTPHPAIRTVLRGFISLLRNIPFLVWASILVVIFGVGSMPGIFSLILFGSGFLARVYAEAIEEIDNHATEALDAMGAGYLQKIKHAIIPAFIPGYISWTLFMFELSIRASSILGLVGAGGIGSQIKLTMDLFQYNRTSTVICILIVLILVIEFMTKRIRERVI
>NC_012914.1|WP_015847552.1|6886906_6887806_+|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein
MKKAVLIMTLFVVALTLLAGCSTSKDGAPKKFVIAYLPGENSDQAQKLNGDFEKKLSEKLGIPVESYKATSYNAAIEAMKNGKADYALFGPFSYIVAVDRANVEPVAEISIPAMANQPASVILVKKDSPIQTLADLKGKTFGYVDPVSTTGHLLPKSILVDQLGITPDEVEKGFFKDVQFAGGHDKAILGLLRGQYDAIGTAAMMPAMLEAKGIIEKDSYRVIGQSQSLPGTALGIRKDLPEDLKAKVKEFLLSYDNPEYLEGIVGSKDAKFIEAKDSDFDGLRDIAKKLNLSPDDLLK
>NC_012914.1|WP_015847551.1|6886087_6886732_-|GntR-family-transcriptional-regulator
MSLIQKAYAYIRERILQGEFMPGALLSEVELAEQLGMSRTPVRSAMSQLESQGYVSAIQNRGIFVKEVSLKEILDMMEVQHAFQRMSLKAIMESGEKPDLNAMQAHLDGQIEATERVDYFSYLQHFYKFNRCLIEASRNTVVLQMFDALQDKMLRFSIVGYKKTPHIPHFSASKISRSILDHLIAGEYEEIREIMDRILIQGKKRMIELNLMKI
>NC_012914.1|WP_041614821.1|6885054_6886023_-|quinone-oxidoreductase
MKALVFETFGGPEVLEYKEIPAPEVKPGTVLVRLKAAGLNYADIYRRRGNYHLAGNPPYILGYEGAGIVEEAAADAAGLAPGDRIAFCDVPHANAELVLVPAEKAIPLPDDISFETAAAVLLQGMTAHYLTQDSYRVQAGDEVLVHAAAGGVGQLLVQLAKRQGARVLGLVSSESKREAALAAGADAALLYDSNWVAAAKKWSTGGEGVSVAYDSVGSTLMDSFAAVKTKGTVVFFGMAGGDPAFVDPRMLMDTSKTLTGGDLWNHVTSREDRIRRAEELFAWLRDGSLKLETPKAFPLAEGADAHRLLESRQSTGKIIFVP
>NC_012914.1|WP_015847549.1|6884412_6884844_-|MerR-family-transcriptional-regulator
MKIFYKIEDVAKMVGLTKRTLRYYEELGLLTPPERSEGGFRLYTDYHVERLKKLINARDVLGFSLQELQQYVAMSEEFINQRDEIRQTEDARLRLRKIDELEQTVDKQLELIDLKLEKMKNMRSEIHQLKDRINEAKKKYKRE
>NC_012914.1|WP_015847548.1|6883156_6884410_-|MFS-transporter
MSVANSSQPAASAANKPLSVEKGGFFNQPRAVWAVFFAGIIAFMGIGLVDPILKAIAEEMHASASEVSLLFTSYNAVMAVAMLITGVVTSRIGIKWTLLLGVVIIAVFSLLGGMSNDIWALVGYRAGWGLGNAFFVATALTAIVSLSKSGVTKAIILYEAAIGIGISVGPLLGGELGSISWRGPFIGVAGLMVIAFLAIIFMMPKTAGAPKASAAPAKKTSLLDPFRALRHRPLVVFGLTACFYNFGFFTLMAYAPFVMGLGIHQLGYVFLGWGILLAVTSVFMAPWLQRRFGTVKSMAVMLTLFGLTLLAMAIWTNTQWVIIASVIFAGALLGNNNTLITTGVMNAAPVERSTASAAYSFLRFIGGAIAPYFAGKLAEWFNPHIPFYVGAGFVIVSVLFILANHKHVKHVDHAGGH
>NC_012914.1|WP_015847547.1|6881846_6882995_-|hypothetical-protein
MSNRKSHYASPADLPLVKELPDPFVFEDGRRVQTLADWEERSQELQDLFHYYMYGYMPDASGEQVTYEKTEQGLRVHVTRGDTEDSFTARISFPPEDGVIGGTYPVIFTIGSLEGWRPDGQDATNYVEQANKRGYAVVTLLPQEIASDNAERTGAFFKLYPYAQAPDQNDVGIFIALGWAASKVLDAFEQQLYPEIDAARAAVTGFSRWGKASLVAGMTDKRFALVNPHASGAGGMAPFRYSFEGKGYPWGIAGRSEPLEALQSEGEAHWFSSVFRQFSDLAALPFDQHELAALIAPRALLLTCGYSDDWINPEGMYVSYAEAEKVYRFLGAEDQIGIAYRHGGHNRTQEDIDHLLDYCDWRLKGIPPVHSDFKSCLYEPWK
>NC_012914.1|WP_015847557.1|6891454_6892156_-|hypothetical-protein
MYPKVRTGRQIWLMRTAIAIAVCFVLFIGFVYAYDRPGGISDWRYARASGISGTIKIPLGATPEEAVRKFRSEATTHIIYREPVAGGALLFTKLNEQKEGNNLGIEFVQKTLLGWKWVYGGTYSYSAADRNEALNFMSIPKYKGIKGPFPIIFGQITNSAITSVKVTVGGDKAGVYNAKIISEGVLQRIWYVILPAAADKPYKLEALNREGNAVASKTSDDPTDFGSIMLLKK
>NC_012914.1|WP_015847558.1|6892171_6893173_-|phosphotransferase
MTNQPMAVSSVLAPDYLMSCLSGQYELGQWTQCVYWLRGLNDTYRVQTEKGTYILRIYRQEVGEREAAYEMALLGQLEDLLTGTEASIASPVMKAGGTRYSVIAAPEGERIAVLFEYVEGIENRLQDEESCYAFGQSAAQLHLAMDQVRLELPRRELDADFLVEESLQLIIRHIGKDHPAAGFLREYANALKDRVASAAAAGLDWGICHGDMHGNNNAVETDGRYTHFDFEWSAPGWRAYDLAQVRNRKRQSAESKEQLWQALLAGYRSVRSFSEKDEQAVELFMLVRRFWIMSLDVHFVPTQSGALDYGEDWLNEFLEEFRSAGLVQHTSQT
>NC_012914.1|WP_015847559.1|6893320_6894172_+|pentapeptide-repeat-containing-protein
MIPDRKHLRGDCDNCFGLCCVALPFAVSADFAIDKQSGQPCRNLQNDYRCGIHTKLRQQGFRGCTVYDCFGAGQKLSQHTFGGRSWREDPQTAKLMVEAFPVMWHLQELLWYLAEAHENPAAKPLQSELHAAWKETERLTGLDAEALLKLDFAAHRAEVNTLLLKTSELVRAKAPNAKTDARRKRTIGRGADLMGAKLQNADLRGANLRGSYLIAADLRGADLRHADLIGADMRDTDLSGADLSESLFLTQVQLQAAKGNADTKLPPALSRPAHWTSKKPATS
>NC_012914.1|WP_015847560.1|6894202_6895021_-|SDR-family-oxidoreductase
MNKTILITGTSSGLGKLTAIHFAKLGWNVAATMRTPENETELTQYSNVKLFKLDVTDVEQVRTAVADAIEAFGRIDVVVNNAGVGAYGALELAKEETIDWQFGVNVRGPINVIRAMLPHFRANKSGMFITISSFMGVTTAVPTGSLYNMSKFALEGLIEGLYYELKPLGIELRLVEQGGSSGNNFVNKIAWGQSGEITDYDEITAKVKAMMGSRAVDELDDPQTIADAIARLALGESKQFRTLVGEAAHQLTDMRKSMPIEKYLEQIAAQYQ
>NC_012914.1|WP_015847561.1|6895136_6895718_-|TetR/AcrR-family-transcriptional-regulator
MFEQYNKVQKAVLETTLQIIIRKELQATSMALIAKESKVSTGSIYHYFSSKEEIINELYTSIVTYNGQFVQEGLNREGTIRERFNWGWERVIETSRQYPEGFQFIEQYSFSPYIYEEVKQKAYNGGWCAPMNKLYADAMEQELFREMDPKLLVQMHYGSMVYMVKSYLQGNSDLTDAGIGQAIEVCWQGAIRG
>NC_012914.1|WP_015847562.1|6896097_6897150_-|hypothetical-protein
MKNRFQELRRSTWSMPDGKQKLAVLEEMIRVADRYMTEEEAYHARMDYSNAAPECGCPERMLVSFSWCLSKFENNPGEYSNFYIMWHYKWVLGYVWRMPELSLEQIERIYEDFKEKCVTYGYSLRVYYQKRVSLMLWQGKLAEAADYYKSWRAAKRDSLSDCSACEQNMFGSYHFAINHHKKGLQSLKPILEGKMSCRSIPESTYSEMMMPLLKLGEYDRALETAKKAYRALKGPSYLEEYGTFLQFFTVTDMPKAVKLYEQTIRLGLGSKLGWDRLQYMLSVRIFLKEWSKGKRRKKLAESETVTLAWLDEEIERLAQAFNRRNGNTFVEDLVREKEKMAARLQTAYGT
>NC_012914.1|WP_015847563.1|6897146_6898922_-|HSP90-family-protein
MNFQVNLQGIIDLLSNHLYSDPGVFVRELLQNAVDAVTARKRLGHITEGKVAVELFPSSHTISFMDNGIGLTESEIEQFLARIGSTTKKADQDSADDYIGQFGVGLLSCFVISDEIVLITRSALDGDSLEWRGKPDGTYVTNKLKRTVPIGTTVYLKLKPEYEEYAEWYKMYQQLERFGKYLETPIVLTEDKDSRQINDTTPPWRMSQSEAISYIEDSEYEKPMDIIPLKSLIGDTEGIAYILPYSVSLQDEKRHKVYLKRVLLSDKMNNILPSWAFFVNGIINTNSLRPTASRESFQENDLFYAVRDELGVCIKRYLIELADNDPELFARIVLIHYASIKTMAAEDEELYELFILHLSFETSFGDLKMADILRNHRTVMVTSSFDEFRQVARVAKAQNMMVINGGYVHDLELVRKLPSIDEQVQVSVLDILSFSSRFESLGRSERDEVQPFLDLADRLLAPYQCRSLIKWFEPADIPVLFNINQEVNFFKMMEESEEQANTLFAEVIHVIKDELYEKPYARLCFNYNNPIVRKAIASGDLKLQQNSIELLYTQALLMGNHPLSSEELRLMNESLLQFMNMGLDRNAEVGR
>NC_012914.1|WP_015847564.1|6899111_6899969_-|D-Ala-D-Ala-carboxypeptidase-VanY
MKKWVFAFILVILLSYGISQLNVKSAGEDKVDIENGSLPQQDSKMITVSKEQMYKGDLLLVNNDYALHPEGIRSDIVSLSDRQDLVQGYGLLDPSIQLSESVAKDFGEMVKGAKKDGVEHFLISSGYRDAEKQDQLYRDMGHDYALPAYHSEHNLGLSLDIGSTTAKMDEAEEGKWLKKHAWEYGFILRYPKGKEDITGIQYEPWHFRYVGKAHSAIMYKQDLTLEQYLDKLKQTKAMSITADGQKYTVAYYPMVGSGATIQVQNGKPYEVSGNNYDGVIVTMYA
>NC_012914.1|WP_015847565.1|6900053_6901151_-|HAMP-domain-containing-histidine-kinase
MPFKAKKLRSFRTRMIELFVMSLLISGAVTYLIYRLLKSYYNQRVRYADDPIVQARSWLNDIGDLNFFLIFFLPLSFFFFYLFTKPYVSYFKEISTGIHRLANGDFTGRVMVPSDDEFGVIAGDLNVAGEMLQKAVERGDFAESSKDQLVLNLAHDLRTPLTSVLGYLDFILRDEQLSLEQVRHFAAIAFNKSQRLERLVDELFEVTRMNYGMLTLDKKQIDLSELLMQLSEELYPVFVKSRLTARLELPPHLVMEADGELLARVFENLLTNAARYGQDGEYVDIKGRTENGHAILEIINYGDSIKPEDLPHLFDMFYTGDRARSPEGSTGLGLFIVKNIVEQHQGIITAESSTIRTVFTVKLPI
>NC_012914.1|WP_041614824.1|6901134_6901845_-|response-regulator-transcription-factor
MQRTTILIAEDDPDIAELIALHLGKEGYQLLKAADGREAVRLVQTNTIDLVILDIMMPHMDGYEVVRVIREQQYRMPIIFLSAKTSDFDKISGLVMGADDYMTKPFNPMELLARVNAQLRRFRQLNQPVAAPTHAASAIVAGGLTIDQEQRNVTLYNDRIDLTPKEFDILYLLASHPKKVFSAEHIFQQVWGEAYYESGGNTVMVHIRTLRKKLGEDKQHQQWIKTVWGVGYAFQG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_012914_8	8.2\|5070595\|22\|NC_012914\|CRT	5070595-5070616	22	NZ_CP015882	Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence	1250771-1250792	2	0.909
NC_012914_8	8.2\|5070595\|22\|NC_012914\|CRT	5070595-5070616	22	NZ_CP030264	Ensifer adhaerens strain Corn53 plasmid AB, complete sequence	1169880-1169901	2	0.909
NC_012914_8	8.4\|5070694\|22\|NC_012914\|CRT	5070694-5070715	22	NZ_CP015882	Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence	1250771-1250792	2	0.909
NC_012914_8	8.4\|5070694\|22\|NC_012914\|CRT	5070694-5070715	22	NZ_CP030264	Ensifer adhaerens strain Corn53 plasmid AB, complete sequence	1169880-1169901	2	0.909
NC_012914_1	1.1\|461028\|26\|NC_012914\|CRISPRCasFinder	461028-461053	26	MN694623	Marine virus AFVG_250M512, complete genome	25409-25434	3	0.885
NC_012914_4	4.1\|715212\|25\|NC_012914\|CRISPRCasFinder	715212-715236	25	NZ_CP011520	Pandoraea oxalativorans strain DSM 23570 plasmid pPO70-3, complete sequence	17605-17629	3	0.88
NC_012914_9	9.3\|5978436\|29\|NC_012914\|CRISPRCasFinder	5978436-5978464	29	MN693606	Marine virus AFVG_25M129, complete genome	29726-29754	6	0.793
NC_012914_9	9.5\|5978561\|29\|NC_012914\|CRISPRCasFinder	5978561-5978589	29	MH617717	Inoviridae sp. isolate ctcc37, complete genome	56-84	7	0.759
NC_012914_2	2.1\|515540\|32\|NC_012914\|CRISPRCasFinder	515540-515571	32	NC_012782	[Eubacterium] eligens ATCC 27750 plasmid unnamed, complete sequence	51898-51929	9	0.719

1. spacer 8.2|5070595|22|NC_012914|CRT matches to NZ_CP015882 (Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence) position: , mismatch: 2, identity: 0.909

agacaccgcacctggccagcca	CRISPR spacer
cgacacctcacctggccagcca	Protospacer
 ****** **************

2. spacer 8.2|5070595|22|NC_012914|CRT matches to NZ_CP030264 (Ensifer adhaerens strain Corn53 plasmid AB, complete sequence) position: , mismatch: 2, identity: 0.909

agacaccgcacctggccagcca	CRISPR spacer
cgacacctcacctggccagcca	Protospacer
 ****** **************

3. spacer 8.4|5070694|22|NC_012914|CRT matches to NZ_CP015882 (Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence) position: , mismatch: 2, identity: 0.909

agacaccgcacctggccagcca	CRISPR spacer
cgacacctcacctggccagcca	Protospacer
 ****** **************

4. spacer 8.4|5070694|22|NC_012914|CRT matches to NZ_CP030264 (Ensifer adhaerens strain Corn53 plasmid AB, complete sequence) position: , mismatch: 2, identity: 0.909

agacaccgcacctggccagcca	CRISPR spacer
cgacacctcacctggccagcca	Protospacer
 ****** **************

5. spacer 1.1|461028|26|NC_012914|CRISPRCasFinder matches to MN694623 (Marine virus AFVG_250M512, complete genome) position: , mismatch: 3, identity: 0.885

tgggcattttgagcggatttgtgagt	CRISPR spacer
tgggtattttgagcgaatttgtgagg	Protospacer
****.**********.*********

6. spacer 4.1|715212|25|NC_012914|CRISPRCasFinder matches to NZ_CP011520 (Pandoraea oxalativorans strain DSM 23570 plasmid pPO70-3, complete sequence) position: , mismatch: 3, identity: 0.88

ggttgatctggcgggatttttgatt	CRISPR spacer
ggttgatctgccgggattttagatc	Protospacer
********** ********* ***.

7. spacer 9.3|5978436|29|NC_012914|CRISPRCasFinder matches to MN693606 (Marine virus AFVG_25M129, complete genome) position: , mismatch: 6, identity: 0.793

cacgacctttgccaactaattttactgcc	CRISPR spacer
tacacccttttcaaactaattttactgct	Protospacer
.**. ***** * ***************.

8. spacer 9.5|5978561|29|NC_012914|CRISPRCasFinder matches to MH617717 (Inoviridae sp. isolate ctcc37, complete genome) position: , mismatch: 7, identity: 0.759

tccgtcctgcgcaggctaattttattgcc	CRISPR spacer
taggttctgcgcaggctaattatatttat	Protospacer
*  **.*************** ****  .

9. spacer 2.1|515540|32|NC_012914|CRISPRCasFinder matches to NC_012782 ([Eubacterium] eligens ATCC 27750 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.719

catcggcacttaaagccagctactgggctcaa	CRISPR spacer
actagccacttaaagccctctactgggctact	Protospacer
  * * ***********  **********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1020065 : 1030556

Synechococcus_phage(37.5%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015842488.1\|1020065_1021361_+	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	2.0e-19	25.8
WP_015842489.1\|1021385_1022285_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0M4JBD3	Mollivirus	1.3e-36	31.3
WP_015842490.1\|1022646_1022889_+	phosphoribosylformylglycinamidine synthase subunit PurS	A0A0E3FJ99	Synechococcus_phage	4.8e-07	33.8
WP_015842491.1\|1022892_1023588_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_015842492.1\|1023565_1025809_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	9.2e-161	42.1
WP_015842493.1\|1025793_1027272_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.8e-54	32.2
WP_015842494.1\|1027302_1028346_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	2.0e-70	43.8
WP_015842495.1\|1028345_1028957_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	4.7e-27	37.6
WP_015842496.1\|1029005_1030556_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	2.0e-69	49.2

DBSCAN-SWA_2

1647725 : 1711834

Tupanvirus(12.5%)

tRNA,holin,tail,coat

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015843005.1\|1647725_1648757_+\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2K9L3A8	Tupanvirus	2.4e-31	34.0
WP_015843006.1\|1648775_1651223_+\|tRNA	phenylalanine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_015843007.1\|1651436_1655852_+	hypothetical protein	NA	NA	NA	NA
WP_015843008.1\|1656307_1656988_-	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	3.1e-11	31.8
WP_015843009.1\|1657185_1657554_-	cupredoxin domain-containing protein	NA	NA	NA	NA
WP_015843010.1\|1657710_1658079_-\|holin	phage holin family protein	NA	NA	NA	NA
WP_015843011.1\|1658232_1660602_+	endonuclease MutS2	Q94M10	Lactobacillus_phage	1.7e-11	37.4
WP_015843012.1\|1660653_1661076_+	DUF350 domain-containing protein	NA	NA	NA	NA
WP_015843013.1\|1661235_1661748_+	hypothetical protein	NA	NA	NA	NA
WP_150106622.1\|1661859_1663110_+	MFS transporter	NA	NA	NA	NA
WP_015843015.1\|1663318_1664236_+	cysteine synthase A	A0A1X9I5K7	Streptococcus_phage	5.7e-85	55.4
WP_150106623.1\|1665135_1666170_-	CotH kinase family protein	NA	NA	NA	NA
WP_015843017.1\|1666516_1667287_+	hypothetical protein	NA	NA	NA	NA
WP_041613334.1\|1667366_1668032_+	hypothetical protein	NA	NA	NA	NA
WP_015843019.1\|1668147_1669272_+	endospore germination permease	NA	NA	NA	NA
WP_015843020.1\|1669261_1670761_+	spore germination protein	NA	NA	NA	NA
WP_015843021.1\|1670757_1671930_+	Ger(x)C family spore germination protein	NA	NA	NA	NA
WP_015843022.1\|1671995_1672217_+	hypothetical protein	NA	NA	NA	NA
WP_015843023.1\|1672354_1672741_+\|coat	spore coat protein	NA	NA	NA	NA
WP_015843024.1\|1672835_1673327_+	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_015843025.1\|1673340_1674543_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	A0A1X6WGT4	Pacmanvirus	4.5e-05	25.3
WP_015843026.1\|1674641_1675223_+	cob(I)yrinic acid a,c-diamide adenosyltransferase	NA	NA	NA	NA
WP_015843027.1\|1675219_1676170_+	RluA family pseudouridine synthase	A0A2H4UV25	Bodo_saltans_virus	3.8e-07	25.0
WP_015843028.1\|1676187_1676550_+	arsenate reductase family protein	M1PLC0	Streptococcus_phage	4.6e-22	47.8
WP_015843029.1\|1676554_1677748_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_015843030.1\|1678407_1679265_+	5'-3' exonuclease	F8WQ40	Bacillus_phage	5.6e-26	31.3
WP_015843031.1\|1679550_1688280_+	S-layer homology domain-containing protein	A0A2D1GMQ7	Marinobacter_phage	5.2e-26	25.9
WP_015843032.1\|1688428_1688911_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_015843033.1\|1688907_1689426_+\|tail	phage tail protein	A0A2R4A082	Microbacterium_phage	2.3e-14	33.1
WP_015843034.1\|1689449_1689947_+\|tail	phage tail protein	A0A221J6G5	Arthrobacter_phage	1.9e-18	36.5
WP_015843035.1\|1689966_1690491_+\|tail	phage tail protein	A0A222ZG41	Arthrobacter_phage	3.8e-17	33.3
WP_015843036.1\|1690547_1690820_-	hypothetical protein	NA	NA	NA	NA
WP_015843037.1\|1690877_1691174_-	DUF3055 domain-containing protein	NA	NA	NA	NA
WP_015843038.1\|1691386_1692370_+	HRDC domain-containing protein	NA	NA	NA	NA
WP_015843039.1\|1692402_1693377_-	zinc dependent phospholipase C family protein	NA	NA	NA	NA
WP_015843040.1\|1693544_1694006_+	chemotaxis protein CheX	NA	NA	NA	NA
WP_015843041.1\|1694122_1694896_+	SDR family oxidoreductase	A0A0N9R355	Chrysochromulina_ericina_virus	8.4e-05	25.5
WP_015843042.1\|1694920_1696339_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	8.4e-43	31.4
WP_015843043.1\|1696567_1697767_+	S-layer homology domain-containing protein	NA	NA	NA	NA
WP_015843044.1\|1697901_1698654_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.1e-21	30.8
WP_015843045.1\|1698650_1699904_+	ABC transporter permease	NA	NA	NA	NA
WP_041613339.1\|1699978_1701274_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_015843048.1\|1701670_1702456_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015843049.1\|1702734_1703523_-	phosphatidylserine decarboxylase	A0A2K9L6Z6	Tupanvirus	1.2e-25	31.2
WP_015843050.1\|1703696_1705010_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_015843051.1\|1705111_1711834_+\|tail	WIAG-tail domain	NA	NA	NA	NA

DBSCAN-SWA_3

1810010 : 1858254

Paenibacillus_phage(32.14%)

head,protease,capsid,portal,holin,terminase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015843132.1\|1810010_1811270_+\|tRNA	tyrosine--tRNA ligase	A0A1L2CUL7	Pectobacterium_phage	1.4e-81	40.5
WP_190276182.1\|1811493_1812033_+	hypothetical protein	NA	NA	NA	NA
WP_150106449.1\|1812484_1814674_+	hypothetical protein	NA	NA	NA	NA
WP_015843136.1\|1814866_1816006_+	methyl-accepting chemotaxis sensory transducer	A0A2H4J162	uncultured_Caudovirales_phage	4.3e-13	35.3
WP_190276183.1\|1816189_1816987_+	phosphate ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.9e-16	30.9
WP_041614094.1\|1817009_1817681_+	phosphate signaling complex protein PhoU	NA	NA	NA	NA
WP_015843139.1\|1817839_1819735_+	S-layer homology domain-containing protein	NA	NA	NA	NA
WP_015843140.1\|1819865_1822538_+	DNA polymerase I	A0A218MKQ4	uncultured_virus	7.1e-59	29.4
WP_015843141.1\|1822635_1823499_+	DNA-formamidopyrimidine glycosylase	A0A127AWE5	Bacillus_phage	2.2e-17	29.1
WP_015843142.1\|1823612_1824317_+	sporulation membrane protein YtaF	NA	NA	NA	NA
WP_015843143.1\|1824361_1824958_+	dephospho-CoA kinase	NA	NA	NA	NA
WP_015843144.1\|1824954_1825521_+	lytic transglycosylase domain-containing protein	A0A0H3V0Q1	Geobacillus_virus	1.6e-16	40.9
WP_015843145.1\|1825603_1825813_-	alpha/beta-type small acid-soluble spore protein	A0A1P8CX76	Bacillus_phage	5.2e-10	49.3
WP_015843146.1\|1825930_1826398_+	transcriptional regulator NrdR	NA	NA	NA	NA
WP_015843147.1\|1826477_1826861_+	VOC family protein	NA	NA	NA	NA
WP_015843148.1\|1826955_1828683_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_015843150.1\|1829507_1829897_+	hypothetical protein	NA	NA	NA	NA
WP_015843151.1\|1829890_1830085_-	hypothetical protein	NA	NA	NA	NA
WP_015843152.1\|1830174_1830903_+	hypothetical protein	NA	NA	NA	NA
WP_015843154.1\|1831554_1831947_+	hypothetical protein	A0A076G7Y2	Bacillus_phage	3.6e-44	69.2
WP_015843155.1\|1831943_1832258_+	HNH endonuclease	R9TNN2	Paenibacillus_phage	2.6e-37	71.6
WP_015843156.1\|1832565_1832976_+	hypothetical protein	R9TQ46	Paenibacillus_phage	5.1e-25	55.5
WP_015843157.1\|1832972_1834685_+\|terminase	terminase large subunit	A0A290GJW3	Caldibacillus_phage	1.5e-227	67.7
WP_015843158.1\|1835106_1836342_+\|portal	phage portal protein	A0A0A8WJ25	Clostridium_phage	3.0e-73	41.3
WP_015843159.1\|1836310_1836946_+\|head,protease	HK97 family phage prohead protease	A0A2H4JBV4	uncultured_Caudovirales_phage	1.0e-16	38.2
WP_049790125.1\|1836990_1838193_+\|capsid	phage major capsid protein	H7BUQ0	unidentified_phage	1.7e-76	53.7
WP_015843161.1\|1838250_1838859_+	hypothetical protein	NA	NA	NA	NA
WP_041614102.1\|1838902_1839184_+	hypothetical protein	R9TMB7	Paenibacillus_phage	6.7e-21	62.1
WP_015843163.1\|1839180_1839492_+\|head	phage head closure protein	R9TPZ2	Paenibacillus_phage	2.3e-22	52.4
WP_015843164.1\|1839495_1839948_+	HK97 gp10 family phage protein	R9TLN1	Paenibacillus_phage	1.3e-42	62.1
WP_015843165.1\|1839955_1840336_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_015843166.1\|1840348_1841056_+	cadherin-like beta sandwich domain-containing protein	R9TNE5	Paenibacillus_phage	4.9e-36	60.6
WP_015843167.1\|1841107_1841458_+	hypothetical protein	R9TMC6	Paenibacillus_phage	1.3e-29	57.9
WP_015843168.1\|1841511_1841793_+	hypothetical protein	R9TPZ6	Paenibacillus_phage	9.5e-07	41.4
WP_015843169.1\|1841843_1844450_+	hypothetical protein	R9TLN4	Paenibacillus_phage	1.1e-75	54.5
WP_015843170.1\|1844490_1844817_+	hypothetical protein	D7RWK1	Brochothrix_phage	7.3e-11	36.6
WP_015843171.1\|1844826_1846401_+	hypothetical protein	NA	NA	NA	NA
WP_015843172.1\|1846400_1846817_+	hypothetical protein	NA	NA	NA	NA
WP_015843173.1\|1846829_1847159_+	hypothetical protein	NA	NA	NA	NA
WP_015843174.1\|1847155_1847377_+	hypothetical protein	NA	NA	NA	NA
WP_015843175.1\|1847389_1847686_+	hypothetical protein	NA	NA	NA	NA
WP_015843176.1\|1847687_1850561_+	hypothetical protein	U5PTP8	Bacillus_phage	1.1e-17	29.4
WP_015843177.1\|1850561_1850921_+	hypothetical protein	NA	NA	NA	NA
WP_015843178.1\|1850921_1851068_+	XkdX family protein	NA	NA	NA	NA
WP_150106627.1\|1851116_1851572_+\|holin	phage holin family protein	S6AVT9	Thermus_phage	2.5e-09	30.5
WP_015843180.1\|1851549_1852359_+	glycoside hydrolase	A0A1U9WQS3	Geobacillus_phage	2.8e-43	39.7
WP_015843181.1\|1852400_1852952_-	hypothetical protein	NA	NA	NA	NA
WP_015843183.1\|1853440_1854238_+	ParM/StbA family protein	E5DV70	Deep-sea_thermophilic_phage	1.6e-46	44.0
WP_015843184.1\|1854230_1854446_+	hypothetical protein	NA	NA	NA	NA
WP_015843185.1\|1854458_1854671_+	hypothetical protein	NA	NA	NA	NA
WP_015843186.1\|1854771_1855218_+	hypothetical protein	NA	NA	NA	NA
WP_049790032.1\|1855219_1855915_+	M23 family metallopeptidase	S6B1Q4	Bacillus_phage	6.2e-23	45.2
WP_015843187.1\|1855911_1858254_+	hypothetical protein	A0A2H4J056	uncultured_Caudovirales_phage	4.2e-116	32.5

DBSCAN-SWA_4

1861795 : 1880737

Paenibacillus_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015843194.1\|1861795_1862443_-	helix-turn-helix domain-containing protein	E5DV74	Deep-sea_thermophilic_phage	1.4e-56	57.5
WP_015843195.1\|1862618_1862831_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_015843196.1\|1862863_1863493_+	Rha family transcriptional regulator	A0A2I7SDG8	Paenibacillus_phage	1.5e-39	49.7
WP_015843197.1\|1863504_1863948_+	hypothetical protein	NA	NA	NA	NA
WP_015843198.1\|1864192_1864456_+	hypothetical protein	NA	NA	NA	NA
WP_015843199.1\|1864455_1865061_+	hypothetical protein	A0A1B2AQ10	Phage_Wrath	3.3e-49	50.5
WP_015843200.1\|1865060_1866605_+	hypothetical protein	A0A0C5AN00	Paenibacillus_phage	1.0e-86	39.0
WP_015843201.1\|1866601_1866847_+	hypothetical protein	NA	NA	NA	NA
WP_015843202.1\|1866836_1867736_+	recombinase RecT	A0A0C5AEC1	Paenibacillus_phage	1.2e-82	54.1
WP_015843203.1\|1867739_1868279_+	HNH endonuclease	R9U8P9	Vibrio_phage	2.1e-18	39.5
WP_015843204.1\|1868266_1869022_+	MBL fold metallo-hydrolase	A0A0C5AJ83	Bacteriophage	5.8e-67	52.2
WP_015843205.1\|1869022_1869598_+	DUF1642 domain-containing protein	NA	NA	NA	NA
WP_015843206.1\|1869614_1870499_+	replication protein	A0A290FZL4	Caldibacillus_phage	2.5e-21	48.1
WP_041613364.1\|1870467_1870806_+	hypothetical protein	NA	NA	NA	NA
WP_150106628.1\|1870789_1872142_+	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	3.9e-98	46.2
WP_015843208.1\|1872155_1872407_+	hypothetical protein	NA	NA	NA	NA
WP_015843209.1\|1872561_1872873_+	LexA family transcriptional repressor	NA	NA	NA	NA
WP_015843210.1\|1872872_1873445_+	hypothetical protein	A0A2H4J564	uncultured_Caudovirales_phage	2.3e-28	39.6
WP_190276184.1\|1873523_1873697_+	hypothetical protein	NA	NA	NA	NA
WP_015843211.1\|1873901_1874132_+	hypothetical protein	A0A2H4JCC5	uncultured_Caudovirales_phage	2.8e-17	60.8
WP_015843212.1\|1874135_1874708_+	HNH endonuclease	M1PKJ5	Streptococcus_phage	1.8e-28	35.3
WP_041614122.1\|1874713_1875202_+	dUTP diphosphatase	R9TQ23	Paenibacillus_phage	6.6e-32	45.4
WP_015843214.1\|1875204_1876881_+	DNA cytosine methyltransferase	H9C171	Pectobacterium_phage	1.3e-140	41.6
WP_015843216.1\|1877053_1878130_+	site-specific DNA-methyltransferase	A0A1B0VM49	Pseudomonas_phage	5.7e-92	53.0
WP_015843217.1\|1878233_1878662_+	hypothetical protein	NA	NA	NA	NA
WP_150106450.1\|1878743_1879403_+	2-methylcitrate dehydratase	NA	NA	NA	NA
WP_015843219.1\|1879547_1880168_+	hypothetical protein	NA	NA	NA	NA
WP_049790033.1\|1880188_1880737_+	hypothetical protein	A0A0K2CNQ1	Brevibacillus_phage	9.8e-24	37.3

DBSCAN-SWA_5

2504581 : 2517932

Bacillus_phage(62.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015843726.1\|2504581_2506342_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.1e-166	57.5
WP_015843727.1\|2506359_2507034_+	response regulator transcription factor	W8CYM9	Bacillus_phage	3.3e-82	67.6
WP_015843728.1\|2507037_2508111_+	two-component sensor histidine kinase	W8CYF6	Bacillus_phage	1.5e-76	45.9
WP_049790042.1\|2508202_2509684_+	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	4.4e-26	27.6
WP_015843730.1\|2509661_2510351_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.1e-40	40.3
WP_015843731.1\|2510381_2513417_+	efflux RND transporter permease subunit	S5VTK5	Leptospira_phage	8.3e-72	24.6
WP_015843732.1\|2513615_2514803_-	putative glycoside hydrolase	NA	NA	NA	NA
WP_015843733.1\|2514988_2515177_-	hypothetical protein	NA	NA	NA	NA
WP_015843734.1\|2515326_2516166_-	YitT family protein	M1Q1P6	Streptococcus_phage	4.2e-26	29.2
WP_015843735.1\|2516324_2517932_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	1.8e-65	38.8

DBSCAN-SWA_6

2725397 : 2732480

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015843947.1\|2725397_2725829_+	peptidylprolyl isomerase	A0A1B1IVS0	uncultured_Mediterranean_phage	2.3e-20	45.7
WP_015843948.1\|2726314_2727421_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	2.2e-54	34.8
WP_015843949.1\|2727436_2728108_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.6e-39	44.1
WP_190276217.1\|2728176_2729301_+	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	1.4e-101	50.7
WP_015843951.1\|2729343_2729814_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.7e-40	54.7
WP_015843952.1\|2729890_2730670_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	2.4e-07	24.1
WP_015843953.1\|2730638_2731259_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	7.9e-14	29.2
WP_041613423.1\|2731484_2732480_+	methionine ABC transporter ATP-binding protein	F2Y165	Organic_Lake_phycodnavirus	4.9e-05	23.8

DBSCAN-SWA_7

3052711 : 3060496

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015844231.1\|3052711_3053527_+	DNA-formamidopyrimidine glycosylase	A0A1V0SGN5	Hokovirus	3.3e-07	31.8
WP_015844232.1\|3053531_3054362_+	deoxyribonuclease IV	NA	NA	NA	NA
WP_015844233.1\|3054365_3054701_+	cell division protein FtsJ	A0A292GK84	Xanthomonas_phage	3.5e-08	35.3
WP_015844234.1\|3054744_3055764_+	cell division protein FtsJ	NA	NA	NA	NA
WP_015844235.1\|3055883_3057488_+	serine/threonine protein kinase	A0A2P1EMR8	Moumouvirus	1.9e-19	29.5
WP_015844236.1\|3057572_3058271_+	response regulator transcription factor	W8CYM9	Bacillus_phage	3.3e-32	34.2
WP_015844237.1\|3058267_3059623_+	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	1.4e-26	28.7
WP_015844238.1\|3059635_3060496_+	carbon-nitrogen hydrolase family protein	M1HUK8	Acanthocystis_turfacea_Chlorella_virus	1.4e-08	27.4

DBSCAN-SWA_8

5926464 : 5942130

Brevibacillus_phage(31.25%)

tail,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015846710.1\|5926464_5927250_-	glycoside hydrolase family 25 protein	A0A1U9WQS3	Geobacillus_phage	3.7e-48	46.8
WP_015846711.1\|5927239_5927476_-	hypothetical protein	S5MNY8	Brevibacillus_phage	4.1e-11	50.7
WP_015846712.1\|5927475_5927706_-	hemolysin XhlA family protein	A0A0A7RWP8	Clostridium_phage	2.7e-07	37.5
WP_015846713.1\|5927836_5929303_-	hypothetical protein	NA	NA	NA	NA
WP_015846714.1\|5929299_5929923_-	YmfQ family protein	S6BFJ0	Thermus_phage	7.1e-55	54.7
WP_015846715.1\|5929927_5930344_-\|tail	tail fiber protein	NA	NA	NA	NA
WP_015846716.1\|5930343_5931366_-	DUF2793 domain-containing protein	A0A0K1LM04	Rhodobacter_phage	4.7e-11	31.1
WP_015846717.1\|5931370_5931766_-	hypothetical protein	A0A0A7S1G0	Clostridium_phage	7.8e-31	53.4
WP_015846718.1\|5931768_5932830_-\|plate	baseplate J/gp47 family protein	S6AVU3	Thermus_phage	1.1e-95	51.8
WP_041614670.1\|5932830_5933205_-	DUF2634 domain-containing protein	A0A0K2CP95	Brevibacillus_phage	3.9e-24	47.1
WP_015846720.1\|5933204_5933459_-	DUF2577 domain-containing protein	NA	NA	NA	NA
WP_041614672.1\|5933455_5934430_-	hypothetical protein	S5MNC9	Brevibacillus_phage	2.2e-82	45.9
WP_015846722.1\|5934435_5935224_-	LysM peptidoglycan-binding domain-containing protein	S5MUH0	Brevibacillus_phage	1.6e-35	36.2
WP_015846723.1\|5935287_5937447_-	tape measure protein	Q708L7	Streptococcus_phage	2.1e-37	29.9
WP_015846724.1\|5937641_5938049_-	XkdN-like protein	A0A0A7RTN3	Clostridium_phage	6.8e-06	34.4
WP_015846725.1\|5938084_5938552_-\|tail	phage tail tube protein	A0A0A7RVP1	Clostridium_phage	2.8e-40	54.7
WP_015846726.1\|5938565_5939882_-\|tail	phage tail sheath family protein	A0A0A7RTT5	Clostridium_phage	3.9e-111	49.2
WP_015846727.1\|5939885_5940059_-	hypothetical protein	NA	NA	NA	NA
WP_015846728.1\|5940055_5940481_-	hypothetical protein	S5MBU4	Brevibacillus_phage	5.6e-19	37.1
WP_015846729.1\|5940798_5941422_-	RNA polymerase subunit sigma-24	NA	NA	NA	NA
WP_015846730.1\|5941812_5942130_+	helix-turn-helix transcriptional regulator	A0A1B1P7L1	Bacillus_phage	1.9e-16	56.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_012914

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection