CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_012918	Geobacter sp. M21, complete genome	12 crisprs	csa3,RT,cas3,WYL,Cas9_archaeal,DEDDh,cas3HD,cas6,DinG	1	2	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_012918_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012918_1

12076-12173

Orphan

Consensus_repeat	Method
CTTTATCTTTATCTGCCTTTAAGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012918_1

>merge|NC_012918|1|12076-12173|CRISPRCasFinder
CTTTATCTTTATCTGCCTTTAAGAGATTAAGAGGGATGAGCCCTGTACCATGCGATTTCAGGTTTTCCTCAATCTTTATCTTTATCTGCCTTTAAAGG

>NC_012918|1|1|12076-12173|CRISPRCasFinder
CTTTATCTTTATCTGCCTTTAAGAG	ATTAAGAGGGATGAGCCCTGTACCATGCGATTTCAGGTTTTCCTCAAT
CTTTATCTTTATCTGCCTTTAAAGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012918.1\|WP_012773722.1\|11001_12009_+\|NAD(P)H-dependent-glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|234629
NC_012918.1\|WP_012773721.1\|9424_10942_+\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|379311
NC_012918.1\|WP_012773717.1\|1715_2834_+\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|235541
NC_012918.1\|WP_012773718.1\|2948_4043_+\|DNA-replication/repair-protein-RecF	unknown	unknown	gnl\|CDD\|234608
NC_012918.1\|WP_012773719.1\|4051_6442_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	unknown	unknown	gnl\|CDD\|237860
NC_012918.1\|WP_012773726.1\|17481_19629_+\|response-regulator	unknown	unknown	gnl\|CDD\|225115
NC_012918.1\|WP_012773729.1\|21774_22851_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275338
NC_012918.1\|WP_012773731.1\|24076_25030_+\|magnesium/cobalt-transporter-CorA	unknown	unknown	gnl\|CDD\|213369
NC_012918.1\|WP_012773724.1\|14434_15964_+\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|380161
NC_012918.1\|WP_012773728.1\|20757_21513_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|130358
NC_012918.1\|WP_012773730.1\|22943_23963_+\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NC_012918.1\|WP_012773716.1\|118_1501_+\|chromosomal-replication-initiator-protein-DnaA	unknown	unknown	gnl\|CDD\|273037
NC_012918.1\|WP_083776378.1\|20561_20747_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_012773720.1\|6797_9308_+\|DNA-gyrase-subunit-A	unknown	unknown	gnl\|CDD\|235502
NC_012918.1\|WP_012773723.1\|12180_14448_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|380161
NC_012918.1\|WP_012773727.1\|19720_20647_+\|daunorubicin-resistance-protein-DrrA-family-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|130256
NC_012918.1\|WP_012773725.1\|16170_17262_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226702

Protein	Function_ID	Function_description	E-value
NC_012918.1\|WP_012773722.1\|11001_12009_+\|NAD(P)H-dependent-glycerol-3-phosphate-dehydrogenase	gnl\|CDD\|234629	PRK00094, gpsA, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.	0
NC_012918.1\|WP_012773721.1\|9424_10942_+\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|379311	pfam13646, HEAT_2, HEAT repeats. This family includes multiple HEAT repeats.	0.000659594
NC_012918.1\|WP_012773717.1\|1715_2834_+\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|235541	PRK05643, PRK05643, DNA polymerase III subunit beta; Validated.	1.14321e-157
NC_012918.1\|WP_012773718.1\|2948_4043_+\|DNA-replication/repair-protein-RecF	gnl\|CDD\|234608	PRK00064, recF, recombination protein F; Reviewed.	2.66709e-116
NC_012918.1\|WP_012773719.1\|4051_6442_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	gnl\|CDD\|237860	PRK14939, gyrB, DNA gyrase subunit B; Provisional.	0
NC_012918.1\|WP_012773726.1\|17481_19629_+\|response-regulator	gnl\|CDD\|225115	COG2205, KdpD, Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms].	6.86761e-46
NC_012918.1\|WP_012773729.1\|21774_22851_+\|radical-SAM-protein	gnl\|CDD\|275338	TIGR04545, rSAM_ahbD_hemeb, heme b synthase. Members of this family are AhbD (alternative heme biosynthetic protein D), a radical SAM enzyme in sulfate-reducing bacteria and methanogens that performs the last decarboxylations to synthesize heme b from Fe-coproporphyrin III. Members include DVU_0855, previously included in error in TIGR04055, the NirJ2 family thought to be involved in heme d1 biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	2.226e-149
NC_012918.1\|WP_012773731.1\|24076_25030_+\|magnesium/cobalt-transporter-CorA	gnl\|CDD\|213369	cd12835, EcCorA-like_1, Escherichia coli Mg2+ transporter CorA_like subgroup. A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporters Escherichia coli CorA and Salmonella typhimurium CorA (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.	4.31903e-170
NC_012918.1\|WP_012773724.1\|14434_15964_+\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	3.02451e-45
NC_012918.1\|WP_012773728.1\|20757_21513_+\|ABC-transporter-permease	gnl\|CDD\|130358	TIGR01291, Nodulation_protein_J, ABC-2 type transporter, NodJ family. Nearly all members of this subfamily are NodJ which, together with NodI (TIGR01288), acts to export a variety of modified carbohydrate molecules as signals to plant hosts to establish root nodules. The seed alignment includes a highly divergent member from Azorhizobium caulinodans that is, nonetheless, associated with nodulation. This model is designated as subfamily in part because not all sequences derived from the last common ancestral sequence of Rhizobium sp. and Azorhizobium caulinodans NodJ are necessarily nodulation proteins. [Cellular processes, Other, Transport and binding proteins, Other].	6.52767e-23
NC_012918.1\|WP_012773730.1\|22943_23963_+\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	0
NC_012918.1\|WP_012773716.1\|118_1501_+\|chromosomal-replication-initiator-protein-DnaA	gnl\|CDD\|273037	TIGR00362, DnaA, chromosomal replication initiator protein DnaA. DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair].	0
NC_012918.1\|WP_012773720.1\|6797_9308_+\|DNA-gyrase-subunit-A	gnl\|CDD\|235502	PRK05560, PRK05560, DNA gyrase subunit A; Validated.	0
NC_012918.1\|WP_012773723.1\|12180_14448_+\|HAMP-domain-containing-protein	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	3.72629e-68
NC_012918.1\|WP_012773727.1\|19720_20647_+\|daunorubicin-resistance-protein-DrrA-family-ABC-transporter-ATP-binding-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	1.86469e-103
NC_012918.1\|WP_012773725.1\|16170_17262_+\|PAS-domain-containing-protein	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	2.26904e-56

>NC_012918.1|WP_012773722.1|11001_12009_+|NAD(P)H-dependent-glycerol-3-phosphate-dehydrogenase
MAEKIAVIGAGSWGTTLADLLAKKGHEVTLWAYEPELVLEMRDTRENSLFLPGIKLNEGLAFTNDLAQAYRGCSMVLCVVPSQLVRRVMTNSLPFLPREAVIVSASKGIEVDTLATVSEIYQEILPPEQYRNLAALSGPSFAREVALEMPTAVTAAASTEAVARRVQEAFTTSYFRVYRNSDVVGVELGGAIKNVIAIAAGISDGLGFGSNTRAALITRGLAEMTRLGVAMGAQPSTFAGLAGMGDLVLTCTGDLSRNRSVGIQIGQGRTLSEILGEMRMVAEGVKTTESAYNLAKKLGVEMPIIEQMYQMLYQSKPAREAVLELMTRNLKAEGV
>NC_012918.1|WP_012773721.1|9424_10942_+|HEAT-repeat-domain-containing-protein
MQTNRIDNSLKERRDILDLLGKLRGDGISIHEMEKIGQKFQQAGRRALRPLVRELWRENSGELITKYAYILDFFETEDWLDQLIQIALKRKDLGADGKAALMVALEGYGVDVHSPPFKQPPPTPRSTLGETVQGAIRLGEEGMVTFLDDFLSYQQEVQQIVIRELSQSEDPAASRLLAAMLWHEDRTVVLSALQALGRLRNPLAAGVLQDFIADCAEEYSDTAQKCLRRLGFLGVKAPAPRQLLPFHAAYATAPDGDGYRSLLLSRRTAQGRLCVLYLQVHERRGVLAAWGSADLTFEEFRSEVEGFRMQDDLHEVPPSYLLALVRDALYWSRELCYLPADFYMRRGIFAGEEMTPAPFAPTLADLPQQRVLSFEEGESAARALFDNPLFTGWFMASQRVYDYAEECRAGADVEQVLQRFCEELLAPELELIRERLLVSADLMRVLGTPGFEVANVVSLAESLIDNPLPFHLHPFLRFFALESMEIAKESLERGEEPPLRAAEEF
>NC_012918.1|WP_012773720.1|6797_9308_+|DNA-gyrase-subunit-A
MLNQLNKVSVNIEDEMKRSYMDYAMSVIVGRALPDVRDGLKPVHRRCLFAMYDMSNDWNKPYKKSARVVGDVIGKYHPHGDTAVYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDSPAAMRYTEIRMEQLAHELLADLEKETVPYGPNYDDSLKEPLVLPSKFPNLLVNGSAGIAVGMATNIPPHNLTEVIDGIVAVIDNPQLTFEELVELIPGPDFPTGGFIYGREGIMKAYSTGRGIIQMRAKVQIETQKKTERQSIVVTEIPYQVNKARLVEKIAELVKEKKIEGISDLRDESDREGMRIVIELKKDENPTILLNHLYKQTQMQSSFGIIMLAIVNSRPRVLTLRETIDFFIEHRKEIVTRRTIFDLKKAEARAHILEGLKIALDNLDEVIALIKASASPAEAKAGLMERFGLSDLQAQAILDMRLHRLTGLERDKIMEELREILKYIARLKEILASEAEILKIIVGELVELKDKFGDKRRSEIVMQTADISLEDTIVEEDMVVTISHTGYIKRNAVTLYRAQRRGGKGKTGMKTKEEDFVEQLFIASTKDYLMFFTDAGKVYWLKVYEIPEAGRAARGKAIVNLLNLAANEKITTILPVKEFVDDKFIMMATRNGVVKKTNMMEYSHPRVGGIIAVNLDEGDKLITVALTDGKQDVLLASANGKAIRFKEEDVRTVGRVSRGVRGMTLEDEDVVIGMEILNENFTDSTIFTVTENGYGKRTEISEYRSQSRGGKGVITIKTTERNGNVVDIKQVNDDNDLMLITDQGKILRVPVAGFSIIGRNTQGVRLMVKEENERVVAVARLAEKEEQDEPEDGELDEIVELESGEEQGEE
>NC_012918.1|WP_012773719.1|4051_6442_+|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B
MNSEEQGDYGADKIQILEGLEAVRKRPAMYIGSTAAQGLHHLVYELVDNAIDEALAGYCDAVQVIIHLDGSVTVEDNGRGIPTDMHPTEGRSAAEVVLTVLHAGGKFDNSSYKVSGGLHGVGSSVVNALSTRLDLEIRRNGHVYTQTYRKGVPQAPLEITGETKRRGTKITFFPDGEIFETTEFSFDVLSKRLRELAFLNAGVRIKIHDERFDKDHDFFYEGGIRSFVEYLNKNKNLVNPEPIYIRGEKSGVDIEIAMQYNDSYDEKVFSFANNINTHEGGTHLIGFKAALTRTMNTYANTNNLLKNVKVAISGEDLREGLTAVISVKISQPQFEGQTKTKLGNSEVKGYVETLMNEKLATYLEENPAMARKILEKSIDAARAREAARKARELTRRKGALEVGTLPGKLADCQEKDPALCELFLVEGDSAGGSAKQGRDRKYQAILPLKGKILNVEKARFDKMLASQEIRTLISALGTSIGKEDFDIAKLRYHRIIVMTDADVDGSHILTLLLTFFFRQMLELIERGYLYIAQPPLYKIKRGRKEQYLKNEAALQAYLLEEGTEEMTLKLGVGSDERVYRGKQIIPILTQLIDYNELFDKVVKKGINDELLSVFLKTGIKPGLEEMADLIALLPKMKEAFPEVTTEEFGDSIIFAFGNLRVKIDHQIFTVLESYEYGMLLESHKRMRSVMGTGTGVVLGAEDKVVLETESQEDILSFFMESAKKGLYIQRYKGLGEMNPEQLWETTMHQENRVLLQVKIEDAVAAEEIFTVLMGDQVEPRRDFIEQNALNVSNLDI
>NC_012918.1|WP_012773718.1|2948_4043_+|DNA-replication/repair-protein-RecF
MKLIKLKLASFRNLQNIELAPGKKFNVFYGNNGQGKTNLLESIYLLATMKSFKQARNAELIAFGGEFALVKGTVERDQVRREIAVLIEKQGKKAKVDAKLMTRLDDFFGNLNVVLFTPEEISMVRGGPDLRRRYLDRAVFTCDLGYLTAYHDYAKILKNRNALLKVNETAGIEVWTEQLVQAALLVIERRKAYLDRIGRLLQGFYSEISGNDETVQIEYRLHGVDARLFAEDPAEALNQALRAHAAEERRRGSTAIGPHRDDLYFGLNGRGARQFASQGQQRSFVLALKMAEIEHITRCFEAPPVLLLDDMTSELDRERNRNLMEFLKKREMQVFITTTSLHNVDVDELQDNRTFRIKEGKILD
>NC_012918.1|WP_012773717.1|1715_2834_+|DNA-polymerase-III-subunit-beta
MEFRISKEIFMKALQRIQGIVEKRNTMPILSNALLEVQNDQLFITATDLEVGMKSSYPTAAIREGKITVSAKKLYEIVKEMPDEEIHFTTKDNDWVEITCGKARFNIVGLSSEEFPYFPKVKEESFLVFKNEILADMIEKTSYAICYDETKYNLNGVFIKAFDENGENVLKMVATDGHRLSVSQKAITGNITSELSKGVIFPKKGIFELKKMVEEESGEIMLGFMDNSAVIKKGNTVVVMRLIDGEFPDYTKVIPASNDRIVQINRDKFLHSLKRMAILSSEKFKGVKIEVNPELVIISSSNPELGEAREEIEVQYEGNSISARFNAKYLIDVLSVMEQREVELKLKDELSPVIMKAAAEEEFLAVIMPMRL
>NC_012918.1|WP_012773716.1|118_1501_+|chromosomal-replication-initiator-protein-DnaA
MENIWLEAQTNLKQVLTEQTYSTWIDPLKFLGATVDTIVLEVPSSFFQKWVTDKYLAMIKEAISAVNGKSYQIEFHVADEKPEAAPEEKPEKEGKPAREKEKDKDKEKEKDREKEKDKKELVPNLNPKYTFESFVSGPSNQFAYAASQAVANKPATNYNPLFIYGGVGLGKTHLVNAIGNHILAKNPKAKICYYSSEKFMNEMINSLRYKKMDEFRNKFRKMDLLLIDDIQFMAGKEATQEEFFHTFNALYESHKQIVVTSDKFPKDIPGLEERLRSRFEWGLIADIQPPGVETKVAILKKKSDMHAVNLPDDVALFLAEGANSNIRELEGMLIRLEAFASLTGQEITLSMAREVMKDIIVEKTRDITVEMIQKTVAEHFRIKVSELKSDKRIKTLVVPRQIAIYICRELTKASYPEIGEKFGGKDHSTIIHSVKKIEKQMAGDDEFKASVEDIRKKLFT
>NC_012918.1|WP_012773723.1|12180_14448_+|HAMP-domain-containing-protein
MQLRFGIRTKLLLSILAILFVSYSTLLYSSMKTLNASLRTELDRNLATNIKYARSQYLAQAEIAKFSVMQSVVSQSVQQHLRERDSAWFSSRVKHWHAVLPFVDLVVVVDPEEQVLATLQGPRNGGPMELPVVVEQALASKKAILSTELLSGEFMCRAGVEGYCERPDSETLVATVAVPIIGADGGVLGCVVTGDIMNHHPNLPAKLQEVSGNNVEVTLTQRGLRVASSLPERVLESYTLSPAVLDVLERGEVYRGRTAMGTKSYETIIDPLLNSRGEFVGSLSVAISTETVTSGRRENLQYILASAFLGIICSFGMAYIASRHLTGPLRQLAASARRIEEGDLDQRVVGHQRDEVGMLASSFNNMAESLKERDSIINRKTGDLQELNEQLERMVEQRTSALSMEMGRLEAVLTSLAEGVVVTDRDNLVVLFNPAAQQIFELVPHRVVGQSVERLCEMTGFCNVLEQVGEQTPRERNRGGKKEITVKGKRLNVNKATLQDEAGEFAGMVMSLRDVTKEEQVDRMKTEFISTVSHELKTPLTSIKGSLQLLLTRSKWLTDTERQLLTVCFRNTQRLIRLISEILDISGIESGGMIFNFKSLCIGELAVYAVEEIKSYAMGRDITIVNTVGEHLPMVFGDSDRLIQVMTNLLSNAVKFSPEGKVVMVTAEQEGNYVVVSVADRGRVIQWSDRDKLFKKFQQIESTERGKIGGTGLGLAICKEIVERHHGRIFYTAAKEYGNTFSFTVPIIGETDAKG
>NC_012918.1|WP_012773724.1|14434_15964_+|hybrid-sensor-histidine-kinase/response-regulator
MQKDKILIVDDEADIALILKLQLEDAGYETVRARDGVEALEAVAGEQFDLIMLDIKMPRMDGLEVLSRLKGDETPVVMMTAHGSEDIAVDAMKKGALDYISKPFSTDDMLQKVERAIGIDRTRKENARLSQQLDEERRKMEAVLQGMADLLVAVDLQGRIITWSRQAARLLAAEGESLLGKTLEEVLKAEVAGGELPARTVLRTAEPRLDVGYLLKIGSQAVPVLSSAAPLWNANGELAGSVEIIRDISKLKELEQEKEDFVSMLSHDLKSPITAVVGSIDLVRESKLGPVTPDQSEYLNAAIESCEEMVEMIDTLLGIHKFEAGKMKLNFREEDPVLLINRSAAKFQTPAQRGAIRLFTTLPASLPAISADRSLFSRILGNLLSNAVKFTPEGGEIEVSADLVQDPAPVLAHVPQECYPGQELPSEGEFVRIRVRDSGVGIPQESLGSIFDRFVQARNRRQGKTRGTGLGLAFCRKAMDAHGGYIWAKSEPGEGSVFTVLFPALPEEE
>NC_012918.1|WP_012773725.1|16170_17262_+|PAS-domain-containing-protein
MALRESDAGYRELFEENPQPMWVYQRESRRLLAVNEAALRLYGYRREQFLELALEHLSGGEPMGDPGSSQDQQPRCRQMRKDGSSFEAQLVCHPCQFQGERVQLVLVREDGGAQQEAQLRYRVLQQGSLLEAAQRELETFSYSVSHDLRAPLRHIDGFSRALMDDYGTILDGQGKEYLTRICQAAEKMSQLIDAMQQLSRVGRTELSLEKVDLSVKAQVISLELKHREPERRVDFAIEEGVRAEADAKLVRQLLEILMGNAWKFSSKTPSAVIGFGSVELQGETAYFVRDNGAGFDMAYADKLFSVFHRLHRADEFEGSGVGLAIAQRIVARHGGRIWAESAPGAGATFYFTLKGEKQLTIDN
>NC_012918.1|WP_012773726.1|17481_19629_+|response-regulator
MSKELRVLLVEDSEEDSLLLIRELRRGGYKLAHMRVETAESMRRALHDGEWDVVISDYRMPSFDALGALQVLHETGRDIPFIIVSGKIGEDLAVEAMKSGASDYLMKGNLARLVPVMERELREAEERRTHRLTQEAVRRGKAEWESVFDSVSDLIIITDADGIVLRCNGRVKAYFPGGYGAIIGRRIDEIFFGSAQPEGKLFRFLHSVQSEADEDIRFPNLSGWYNVASYPMRAEGSNRPNLVFIIKDITKRREVEEEKRTSDRELLTLYAVAFRLQYTKGVDKVMGDLLFQLHNMLQMDFSCIHLLEDDKLKMRASLGLSPAFEKAMKTLPRETQWATLAQAGRPFLGEEPDARFPARAKSAAIEMGLHSWCTVPLKIGQEVMGVMTVGTLSGRSYSDRDVFLLCSIAGQLAVLIDNYSLYDKMKEKAEELYRSKVELKENLQKVKRANIELGRLNTAKNNFIGIASHELKTPITSIMGGVEFLLKYSGIQMTPEQHNIFVSVYEGTIQLRKLVEDLLSISRIEAQGPLAQKKPASLMRICREVHDLFALPLSERHIAVEISGDDVLVPVDEAFAMLAVRNLLENAIKFTRDGGSVRLTGRVLKQAQLKEMTPTLHTFYPSFPGNVAATEKYYLLQVRDNGIGIPPDERVRVFEKFYGVGDIDHHSSGATAFMSKGSGLGLSIVRGIMDAHEGAVWVEEAEGGGSAFSLLFPVE
>NC_012918.1|WP_012773727.1|19720_20647_+|daunorubicin-resistance-protein-DrrA-family-ABC-transporter-ATP-binding-protein
MPHAIRLHEITKSYGGFKAVDRFSLEVERGTVFGLLGPNGAGKTTLIKILTTLMRPTHGDAFIEEFSILAAGKSVRRVIGVVPQENNLDRYLTARENLALHGRLHGMRAAAYNRRIDELLEMTGLTSRQNDFPDTFSGGMQRRLVVARALVHEPRVLFLDEPTTGLDPQSRRALWEYVRGLRRNMTVFLTTHYMDEADALCDRIMIMDHGVCLADGTAAELKDAFSRAHVYQVEFRRDSDRYEGMLAGLPFVRSVERSGSTFQITLSDEESIKPLMDCLGGADIRRICLKEPTLEEVFISLTGEKLRE
>NC_012918.1|WP_083776378.1|20561_20747_+|hypothetical-protein
MPTSAGSASRSRPWRRFSSRSPGKNCGNSRQTGQTGRTGQTGQTGQTGQTGQTGQTGQTGA
>NC_012918.1|WP_012773728.1|20757_21513_+|ABC-transporter-permease
MFKGAFSIWGRDMMVLRRSIFSELVAVIAYPLTLYLAFGFGLKGYITDVNGVPYPLFIAPGLISMTAINAAFDESSWSMWFHRRVQRTIEEYRVTPITVYDIVIGKILSGFSQGAVKGSVVFLVILLFTPFRIDYSHLPVYLMCIAISSMTFSCLGTICGTVIDKPENIGRVQSVVIVPLIFMAGIFFPLSSYPASIRPFIELLPTTAVFEGARDALLQGSVPAPYLLNLVATAAVSFLVAVYTFDRKMAE
>NC_012918.1|WP_012773729.1|21774_22851_+|radical-SAM-protein
MAEEFVPKWIAWETTQRCNLKCVHCRCSSELTSSEGDFSTEEGKKLLKEISDFSKPVVVLSGGEPLMRPDIFELAEYGTSLGLRMCMASNGSLVTDEVCEKMKKADIKMVSLSLDGSTAEVHDNFRQCPGSFEGVLRAAELFRKHGQKFLINSSFTKRNQHDIANTFKVAKSLGATAWYMFMIVPTGRGEDIMSELISKEDYEEILDWHYHQEKNEDDILMRPTCAPHYYRIVPQKAKAEGEKFERRSLTFSTGGGKGCIAAQTICLIDCYGNLKPCSYFHRTAGNVKQTPFRELWENSEIFKDLRDFKSYKGKCGECEYLNVCGGCRARADAVHGDYMEEEPFCNYVPIKLQKKQKD
>NC_012918.1|WP_012773730.1|22943_23963_+|uroporphyrinogen-decarboxylase
MNTRFLDACWGKPVDTVPVWLMRQAGRYLPDYMRVRSKCTFLELCKTPELATEVTVQPVDILGVDAAILFSDILTPIEPMGMELDFTPGPVFAKPIRTMADVEALKIPKMETDVPYVLDAVKLLRKELAAKVPLIGFGGAPFTLACYMVEGKGSKDFAALKKMMYADPEVYAALMEKITTMDMEYLNAQIKAGAQAIQIFDTWGGMLSPADYERYVLPYTQRLINGLDRTNIPVIHFVKGAGTMLEIVKQAGGDVMGLDWHVNLGKARDILGDMAVQGNLDPTVLFAPNEIIEREVKRVLDENAGRPGLIFNLGHGILPTVPPEKAIFMVDCVHRLSRK
>NC_012918.1|WP_012773731.1|24076_25030_+|magnesium/cobalt-transporter-CorA
MLRLFRIEDGLIKEMDFEKSDLPNQILHADWIDAHEPDDEERDLLELLLHTDIPESDEVDEIEISARCFVDQAGIHVHPLFLSQSEGRHVTLTVACILQSKHLITIREGDLADFRLLRMRARRGQVECRTPSELLVLLLDQKVENHADTLEDIHRQLEGVSHLVLEDDDSELEDAISKLAKLEDSNGKIRLCLMDTQRDISFLLRHLRDRADQSETLREIARDVETLMSHTTFLFDKINFLMDSTQGFINIEQNQIIKIFSIAAVVFLPPTLVASIYGMNFDVMPELKLSFGYPWALALMILSGIAPYWYFKRKGWL

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Crispr_ID: NC_012918_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012918_2

36416-36518

Orphan

Consensus_repeat	Method
CGGAACGGAGTGTTTGGTGACTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012918_2

>merge|NC_012918|2|36416-36518|CRISPRCasFinder
CGGAACGGAGTGTTTGGTGACTTGCTCAGCAGCCGTTCAATGTTCAAGGTTCAAGGTTCGACAACGTGTATAGCCCTAGCGGAACGGAGTGTTTGGTGACTTG

>NC_012918|2|2|36416-36518|CRISPRCasFinder
CGGAACGGAGTGTTTGGTGACTTG	CTCAGCAGCCGTTCAATGTTCAAGGTTCAAGGTTCGACAACGTGTATAGCCCTAG
CGGAACGGAGTGTTTGGTGACTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012918.1\|WP_012773747.1\|40710_42420_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_012918.1\|WP_012773736.1\|29323_30172_-\|sulfide/dihydroorotate-dehydrogenase-like-FAD/NAD-binding-protein	unknown	unknown	gnl\|CDD\|235747
NC_012918.1\|WP_012773748.1\|42771_44580_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_012918.1\|WP_012773743.1\|35695_36277_-\|hydrogenase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|376886
NC_012918.1\|WP_012773745.1\|38615_39569_-\|heterodisulfide-reductase-subunit-B	unknown	unknown	gnl\|CDD\|224959
NC_012918.1\|WP_012773742.1\|34633_35578_-\|Fe-S-oxidoreductase	unknown	unknown	gnl\|CDD\|379244
NC_012918.1\|WP_012773738.1\|31708_32230_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226648
NC_012918.1\|WP_012773746.1\|39565_40150_-\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|224072
NC_012918.1\|WP_012773735.1\|27917_29327_-\|NADPH-dependent-glutamate-synthase	unknown	unknown	gnl\|CDD\|236967
NC_012918.1\|WP_012773752.1\|49819_49999_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_157506080.1\|40266_40404_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_012773751.1\|48858_49677_-\|AAA-domain-containing-protein	unknown	unknown	gnl\|CDD\|336785
NC_012918.1\|WP_012773749.1\|44777_46688_+\|selenocysteine-specific-translation-elongation-factor	unknown	unknown	gnl\|CDD\|182508
NC_012918.1\|WP_012773744.1\|36583_38581_-\|CoB--CoM-heterodisulfide-reductase-iron-sulfur-subunit-A-family-protein	unknown	unknown	gnl\|CDD\|224070
NC_012918.1\|WP_012773739.1\|32229_32421_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_012773750.1\|46820_48770_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350608
NC_012918.1\|WP_012773737.1\|30509_31385_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|307170
NC_012918.1\|WP_012773741.1\|33454_34465_-\|heterodisulfide-reductase-subunit-A	unknown	unknown	gnl\|CDD\|379938
NC_012918.1\|WP_012773734.1\|26548_27586_-\|cytochrome-c-peroxidase	unknown	unknown	gnl\|CDD\|224771
NC_012918.1\|WP_012773740.1\|32491_33334_-\|heterodisulfide-reductase-subunit-F	unknown	unknown	gnl\|CDD\|99817

Protein	Function_ID	Function_description	E-value
NC_012918.1\|WP_012773748.1\|42771_44580_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	6.63025e-173
NC_012918.1\|WP_012773736.1\|29323_30172_-\|sulfide/dihydroorotate-dehydrogenase-like-FAD/NAD-binding-protein	gnl\|CDD\|235747	PRK06222, PRK06222, sulfide/dihydroorotate dehydrogenase-like FAD/NAD-binding protein.	2.91905e-157
NC_012918.1\|WP_012773743.1\|35695_36277_-\|hydrogenase-iron-sulfur-subunit	gnl\|CDD\|376886	pfam02662, FlpD, Methyl-viologen-reducing hydrogenase, delta subunit. This family consist of methyl-viologen-reducing hydrogenase, delta subunit / heterodisulphide reductase. No specific functions have been assigned to this subunit. The aligned region corresponds to almost the entire delta chain sequence and contains 4 conserved cysteine residues. However, in two Archaeoglobus sequences this region corresponds to only the C-terminus of these proteins.	2.06839e-74
NC_012918.1\|WP_012773745.1\|38615_39569_-\|heterodisulfide-reductase-subunit-B	gnl\|CDD\|224959	COG2048, HdrB, Heterodisulfide reductase, subunit B [Energy production and conversion].	1.29917e-70
NC_012918.1\|WP_012773742.1\|34633_35578_-\|Fe-S-oxidoreductase	gnl\|CDD\|379244	pfam13534, Fer4_17, 4Fe-4S dicluster domain. This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	2.91864e-06
NC_012918.1\|WP_012773738.1\|31708_32230_+\|AAA-family-ATPase	gnl\|CDD\|226648	COG4185, COG4185, Uncharacterized protein conserved in bacteria [Function unknown].	1.13697e-42
NC_012918.1\|WP_012773746.1\|39565_40150_-\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|224072	COG1150, HdrC, Heterodisulfide reductase, subunit C [Energy production and conversion].	2.44414e-19
NC_012918.1\|WP_012773735.1\|27917_29327_-\|NADPH-dependent-glutamate-synthase	gnl\|CDD\|236967	PRK11749, PRK11749, dihydropyrimidine dehydrogenase subunit A; Provisional.	0
NC_012918.1\|WP_012773747.1\|40710_42420_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.27453e-160
NC_012918.1\|WP_012773751.1\|48858_49677_-\|AAA-domain-containing-protein	gnl\|CDD\|336785	pfam07728, AAA_5, AAA domain (dynein-related subfamily). This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.	1.18314e-14
NC_012918.1\|WP_012773749.1\|44777_46688_+\|selenocysteine-specific-translation-elongation-factor	gnl\|CDD\|182508	PRK10512, PRK10512, selenocysteinyl-tRNA-specific translation factor; Provisional.	1.97984e-115
NC_012918.1\|WP_012773744.1\|36583_38581_-\|CoB--CoM-heterodisulfide-reductase-iron-sulfur-subunit-A-family-protein	gnl\|CDD\|224070	COG1148, HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion].	0
NC_012918.1\|WP_012773750.1\|46820_48770_-\|hypothetical-protein	gnl\|CDD\|350608	cd14726, TraB_PrgY-like, TraB/PryY confer plasmid-borne pheromone resistance. TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein.	6.44946e-07
NC_012918.1\|WP_012773737.1\|30509_31385_-\|DMT-family-transporter	gnl\|CDD\|307170	pfam00892, EamA, EamA-like transporter family. This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.	3.22947e-15
NC_012918.1\|WP_012773741.1\|33454_34465_-\|heterodisulfide-reductase-subunit-A	gnl\|CDD\|379938	pfam17179, Fer4_22, 4Fe-4S dicluster domain.	1.87333e-46
NC_012918.1\|WP_012773734.1\|26548_27586_-\|cytochrome-c-peroxidase	gnl\|CDD\|224771	COG1858, MauG, Cytochrome c peroxidase [Inorganic ion transport and metabolism].	4.22612e-114
NC_012918.1\|WP_012773740.1\|32491_33334_-\|heterodisulfide-reductase-subunit-F	gnl\|CDD\|99817	cd06221, sulfite_reductase_like, Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is linked to ferredoxin and reduces NH2OH and SeO3 at a lesser rate than it's normal substate SO3(2-). Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+.	2.92905e-131

>NC_012918.1|WP_012773743.1|35695_36277_-|hydrogenase-iron-sulfur-subunit
MHDFEPKIVAFVCTWCTYAGADLAGTSRMQYPANVRVLKFPCTGRIDPVFILRAFQKGADGVLVSGCHPGDCHYMAGNFHARRRFAAFRALLDFVGVDLNRLQFSWVSAAEGGKWVEVVTELTERVRSMGPMLEFKSLEHEELWSTFAEATADKSTTFAEATADKSTTFAEATADKSTVLNTPELKEAYDSIK
>NC_012918.1|WP_012773742.1|34633_35578_-|Fe-S-oxidoreductase
MNAKVNKSEPNSIEQSYYQAVTQAIRAQAVQILQDGTVAGVVGYLPGRRKGTARPALVTTPEEAEKLIFSPACVNNLSVYLTKSKKGVLKQGRVGIVAKGCDMRALAGLMGESQIKREDLFIIAVDCAGVYGSGAERSESVTEANIARKCLECSVHHPEGADFVAGTATELSGLTPLEAEEMARIEALPQAERWAFWKEHFSRCIRCMACRQVCPFCYCEQCLCDKNRPQAVENSPRPAGNTAWHIVRAMHLAGRCGGCAECERVCPMDIPLNLLNRRMARELKELYDYEAGLAPAEKGPLTQYREDDDQSFIK
>NC_012918.1|WP_012773741.1|33454_34465_-|heterodisulfide-reductase-subunit-A
MPQIITEQNLRNLIDLLVKESKVVVGPKEAGSVVLYQPLAAGSELTLDSLPRRSAKELFFPICENILSYQREDGKMQVTDVDRSRFPETVLIGAPPCDAASPAILDAVFSWDYNDEFYLERRRKSTIVGIACTKGDDACFCTAVGLAPDAEAGSDLFLTPLKDGSYACKTVTEKGKALVEAHPGLFGEAASVDAAPFAEQGTEKLDLVKIRTWLEGHFEDPLWEKISDICVGCGSCAFICPACHCFDINDEGSTEQGSRRKHWDACGFSKFTNHASGHNPRDVQNKRYRNRIMHKFKYYDDKFGKTLCTGCGRCVRACPVGIDIAEILSTINGKQD
>NC_012918.1|WP_012773740.1|32491_33334_-|heterodisulfide-reductase-subunit-F
MCQSKNIYLPNLATIEAIVDETPDVRTLRLVFQDEQVRENFSFRAGQFAEYSAFGSGESTFCIASAPTRKGYIECCFRSVGRVTESLRRLEVGDSIGVRGPYGNSFPIEEFYGKSLVFIAGGIALPPLRTVIWNCLDLRDKFKDITIVYGARSEADLVYKRELAEWQERDDVRLVKCVDPGGNGPDFDGKVGFVPNVLEEAAPSSENTVALVCGPPIMIKFTLPVLERLGFADDQIYTTLENRMKCGVGKCGRCNVGNVYVCKDGPVFTAGEVKAMSQEF
>NC_012918.1|WP_012773739.1|32229_32421_+|hypothetical-protein
MKKKELPKDPDLLGSMQALKRSAASALKLARQTNTPCYVMKDGKIVDIAARPAKTTKKAAAGK
>NC_012918.1|WP_012773738.1|31708_32230_+|AAA-family-ATPase
MSDEQKIVIIAGPNGAGKTTFAREFLPQEGNISDFINADLIAAGLSPFNPDAAAVRAGRLMLEEIDQRVAQRRSFAFETTLSGRGYAVKIKDWQDLGYHVKLIFLSLTDADMAVARVAGRVIQGGHNIPEQVIRRRFRAGLKNLEELYKPLVDAWILYDNMESKLNVLDWGEK
>NC_012918.1|WP_012773737.1|30509_31385_-|DMT-family-transporter
MPYLLLTLSALIWSGNFVISRAMNNVIPPAGFVFWRWVVALVVLLPIVLPRLRREWPIVRANLPLIAVCGLFGVTLFNFLIYTAMHYTTAINAALVNSAIPIFILMFARIFYGQRVVLRQHVGIALSLIGVAAIILRGDPSRILTLSFNHGDLLVLLAAIAWGLYSVAIKRYPQGLNPFVFLFSMTVAGLLLLIPFYAFEIAQGQLMSLNQPTILSIAYVGILASVVAFTAWNHGLREVGPHIGGQFVHLMPAFSTILAVIFLGERLQTFHVAGIVLISAGILCATYKIKS
>NC_012918.1|WP_012773736.1|29323_30172_-|sulfide/dihydroorotate-dehydrogenase-like-FAD/NAD-binding-protein
MFEVVSNEILAENLHKMVLVAPRIARARKAGQFVMVRLAQGEERIPLTIGDADPEAGTITLFIQAIGASTRKIVDTPAGGSIRDVAGPLGKETHITNWGRVACVGGGVGTAVLFPLVKALAEAGNEITTIIGGRSSRYVILAEELGALSKNLLITTEDGSLGSKGFVTGPLGEMIADPARAPKAVFAVGPVPMMKAVANMTREPGIETIVSLNPIMIDGTGMCGGCRVQVGSETKFACVDGPEFDAHLVDFDGLSDRLTSYRKEEAVRHAATDCKIAKEVAK
>NC_012918.1|WP_012773735.1|27917_29327_-|NADPH-dependent-glutamate-synthase
MSNDLSPKERMAIERVHMPELPADERSKNFEEVNQGLSPEQAVAEAQRCLQCKSRNCVAGCPVGVSIPEFIDALASDDMPRAAQVLRGDNALPAVCGRVCPQETQCEALCVRGKKGDAVAIGYLERYVADWAMQHPDELITEDAPAPTGKSVAVVGCGPAGLTAAGELARQGHKVTIFEALHDTGGVLRYGIPEFRLPKEIIDREVAVLSRMGVAIECNVIIGKTLTIPQLRSEFDAVFIANGAGLPTMLNILGENLKGVYAANEFLTRVNLMEAGRRADSSTPILQRDEVAVIGGGNTAMDCVRTARRLGAKRAMIVYRRGEAEMPARVEEIKHAKEEGVEFIMLTAPVAIVATEDGWVSALRCQKMELGPADDSGRRRPQAIEGSEFDLPAGIVINAVGTSANPLLTATAPDLTLNKWGNIVTNDEGETSIPGVFAGGDIVRGGATVILAMGDGKRAAAAIDKYLKG
>NC_012918.1|WP_012773734.1|26548_27586_-|cytochrome-c-peroxidase
MKAKWFILLLPLLPGCVDATAKETMSKAQATFKPIPAQAPAIKGNEATKAKVDLGKKLFFDPRLSTSQLISCNTCHDVGLGGADLQETSVGHGWQRGPRNAPTVFNAVYNVAQFWDGRAKDLQTQAKGPVQASVEMNSNPELVVRTLKSIPGYPALFEAAFPGYSDPVTFDNMAKAIEVFEATLVTPDAPFDRFLNGEASALSAREQAGLGVFMEKGCAACHGGINIGGAAYYPFGVREVPAAEIRPESDTGRFKVTNTASDKYVFRAPSLRNVAITQPYFHSGKVWSLRESVVVMGSAQLGMKLNETEVNDTVAFMKSLTGRQPNMDYPLLPPSSDQTPHPQLK
>NC_012918.1|WP_012773744.1|36583_38581_-|CoB--CoM-heterodisulfide-reductase-iron-sulfur-subunit-A-family-protein
MSRIGVFVCHCGENISRTVDVEQVARSAGEIPGVAYACDYKYMCSDPGQNLLKKAVAEHKLDGVVVAACSPRMHEKTFRKAASAAGLNPYLCDMANIREHCSWVHEDKKLATAKAGDIVKLMVERVKKGKSLAPITVPVTKRALVIGGGIAGIQAALDIADAGHQVLLVEREPSIGGHMAQLSETFPTLDCSQCIMTPKMVDVANHPNITLHTFSEVEKVEGYIGNFQVTLKHKARSVDQSKCTGCGICMTKCPKKKIPNEFDQGHGMRTAIYVPFPQAVPNTPVIDRENCTMFQSGKCGVCAKVCGPGAVDFQQEDRFSVEAVGAVVVATGFKLYSIDRKPEGSPIQGYGEFGYGTIPDVIDGMTFERLASASGPTGGKILRPSDGKEPKQVVFIQCVGSRAREKGISYCSKVCCMYTAKHTMLYHHKVHDGQAYVFFMDARTPGKGYDEFWRRAVEEEEAVYIRGMVSRMYQKGEKIVVMGSDIQVGVQVEIEADLVVLATAVQAQDGADLLAQKLGISYDKYNFYSEAHAKLKPVECATAGIYLAGACQGPKDIPDTVSQASAAAAKVMTLFSKDQLERDPVVAKVNEKYCVGCLACKKVCPYGAVEEKEIRDRQGNLVKVVAYVNPGVCGGCGTCQATCPSKSVELDGYTDEQIMAMIESL
>NC_012918.1|WP_012773745.1|38615_39569_-|heterodisulfide-reductase-subunit-B
MTPGKKRLNYSYYPGCSLHASGREYDISTRALFKALNVGLKEVPDWFCCGATPAHNVDELLSLSLCAKNLSLAEQVEGDLAVACAACFSRLKTTQHHLKEDEEKRKQVETAIAGPAALGKPVKHILEILAREFGLSKLEESVKKPLQGLKVASYYGCLLTRPPGVPELDDCEDPSIMEDILRALGAEPVRWSHRMECCGANFTLSRPGVVLKLSNAILESARLAGADCIMVACPLCHGNLDIRQKEIKDAYGAPDSTLFGNIFGSELQQGAPKDQRDLPVFYITQLAALAMGVPSGSLGFESVITDPKPLLREKQLL
>NC_012918.1|WP_012773746.1|39565_40150_-|4Fe-4S-dicluster-domain-containing-protein
MKNKLMHLSNETMNVGFVKKVEALSGSSVRRCFQCGKCSAGCPMSAFMEHPPNRIVRLLQLGQGQRVLAGRSIWYCASCETCTTRCPNKVDLAAIMDALRKLSWDADGPSKESYVQLANRLFIENIRTYGRQYELRLGAAFNMKSGQFLKDLMLGPKLISKGKLKMFHSKNKNVGEIEAIFKRIEEMRKKGEAL
>NC_012918.1|WP_157506080.1|40266_40404_+|hypothetical-protein
MDDHFGGSRKNAAGIYAILKQKSKNLFFLEILEKEQVLKNLALMP
>NC_012918.1|WP_012773747.1|40710_42420_+|ABC-transporter-ATP-binding-protein
MRTCRGAYLGGALLLVGTNLCGLAIPWLLKLAIEELQQPASGRFTPGEYGAMIAAAAVGQGVIRVFSRTTLLNAGRRIEYLLREDLYGKLLTLDRTYFSNWRTGDILSRLANDLTNVRMLLGFGVLSVLNTFIVYIAALILLTRISPFLTICAIAPFPLMIFIVKKLSASMFKTSKRMQEALSRLTTRVEENVSAAAVVKAYCREEGEIETFRQACDGYSDASMAVAKIRGFMLPVMASTGALGTLIILFVGGAQVVRGELTLGGFVAFNGYLAMLVWPTIMLGWILNLVQRGAASMARLGEILNADAEVVEPSDPVDPGEIRGEVEFRNLTFSYGTTEMLRGITLKIPAGSRVGIVGVVGSGKSTLVRMIPRLFPVPDGTVFIDGVDLNCISLEKIRAAVGFVPQEGFLFSRSIAENIAYGKPGAGREEIERAVRIAGLAGDIARFPQGLETLVGERGVTLSGGQRQRVSIARALLKEPSILVLDDPLSAVDADTEEEILSALSGYYGERTVLIVSHRLSPLRGCDQIIVLEQGAIVEQGSHGELLDLGGRYADIHKEEQLKAEIERL
>NC_012918.1|WP_012773748.1|42771_44580_+|ABC-transporter-ATP-binding-protein
MHFGGIYEDEIVGKMYDRRLMGRFFPYLLPYRRLIAAALILLPFVAAAKLVQPWILKLAIDDHITKGVMAGLPSLAALFLGVILAESLLMFAQVYLLQYVGQKVMYDIRVALFSHLQRLSARFFDRTPVGSLVSRLTSDIEVLGEMFAAGIVTVVGDVLVLAGIVAIMLFMNVKLSLVTFSVLPFLVWAAFSFRKWMRAAFRQVRARQSNLSAFLTESIGGMAVVQLFNREKDEAREFRRLNTAYMESNLPVITWDAALFAVVETLSSVAVALIIWYGGGEIVRGTLSFGALVAFIQYIERFFSPIRDLSAKYSVMQGAMASLERIFTLLDNQALEPALLNERSSAEIEKGTPCQAMPSEAGSSICFNDIWFAYSEDAFVLKGFSLQMRRGEKVALVGETGGGKTTVTRLLSRLYDVNRGSITVDGADIRDIPLKTLRKRIGVVLQDPYLFSGTIAYNISLGDPEALKRVEQAAAVVGADRFIRELPKGFEEEVRERGVNFSAGERQLISFARAVAFDPDILVLDEATASVDTASERLIQRGLEGLMQGRTTLVVAHRLSTIRDADRIVVIHHGEKMEEGSHAELMEAKGVYYRLYQLQFKD
>NC_012918.1|WP_012773749.1|44777_46688_+|selenocysteine-specific-translation-elongation-factor
MKHLILGTAGHIDHGKTSLVKALTGVDTDRLKEEKARGITIELGFAHLELPGGLRFGIVDVPGHERFVRTMVAGVGGMDLVLLVIAADEGIMPQTREHLEICQLLGVKRGIVVLTKKDMVEPDWLDLVTEEVREYLAESFLAGAPIVAVSSRSGDGIDSLKAELTRMAGEIEQKRVDSPFRLPVDRVFTVTGFGTVVTGTLLSGAVSVGDEVEILPSGIACRVRGVQSFGSKVEKGGAGERLAVNLQGVDHTDVERGDVVVPKGLYQPTSAVDVRLNYLASAGKELKHRATVRLHSATYEVPAKIILFDRDALQPGDSAYVQLRLARPVLLLPGDPFVLRTYSPQATLGGGTVLDPAPPRRRRRSVEALELLAAAESGADQERIRLLVESSLLSGISVQEMVNRSGMSAKRIEAALAPLLSGGAAIQVVKEPRIFLGKDAFAQLKQKLSEELRDYLEENPMQEGIGKEELKSRIPKRSDPRFFGPLLASMEKEGQALSDRDLVKLPGRKAGVTQDQASVQAALEEALKKGWCEPPTLKELCDMLGCTEKQVLDHANLLAREGRVAKIKGDIFYAPGAVAEVREKLVARLKEKGEITPPEFREITGLSRKFMIPLLEYFDSEKLTIRMGDKRILRKG
>NC_012918.1|WP_012773750.1|46820_48770_-|hypothetical-protein
MPERLHLENFGNVHALPILHYRMEFAHLVREAYEVLKPDCIAIELPRTLEPQFLRAVARLPELSVLAYHVAGQSVFLLVEPADPLIEGARLALKHRIPLHLVDIDLDSYPSHDEQLPDSYAVQRIGLEPFYREVEKLYRELEPCDEDLRRERGMAHRLQQLSAQHQRVLFICGMSHLERIRENFGKPLAQPLTRTHREGVAIFNLHPECCHEVLAEYPFLSSLYETRRSPLPPEPAQAASLRKSFNAFELILGGKQSIPEEQALLESIQRSAHRVGSEGEMPDRQKVMLRLFLEAARHYRQETGDKVHYWQKRAFFRFVRNYALLSQMLLPDLYQMLAAARGCLDDNFAYAFFRLAAHYPWQSEQSDIPTLRLSAAELSAGTRRIRFRPREQVRGKGRSGIKMTNRRKEKRPGDWLEGFDDPYICSYPPEDLSIEEYGRNLKRIGARQLSEEASRTEPFSASLLDGIDMRETIRNLHEGKIYVKENKRLKSGVGCVVVVFDEDREDSGYPYCMTWLGEHDQESDMAFYATPPTDNIVGPGISRCEYGGFLLSYPPRRMHDVWQDPDYRGALGKGEVLLMAALDYSLEKDVVYAAAKPPRSYLKQQAARLGKRIIYLPLGSLSPVALKRLRAFHILYGKDKRDIAKEYIW
>NC_012918.1|WP_012773751.1|48858_49677_-|AAA-domain-containing-protein
MERITLDGINLTLANPIELPLRWVGDEELLKQLLAAWMVIDERDIPFNPRLIGKPGVGKTTLAYAAAKRLERKVYLFQATMDTRPEDLIVTPVIGPEGSIQYAASSLVSAMISGGVLILDEGNRMSEKAWASLAPLLDDRRYVESIITGLRITAHPDFRIVVTMNEDSSTFEVPEYIHSRLQPQLFIDFPEADEELAILKENLPFAGSSILNYVVQFLQRGHAADEPYSVRDGINIARYALKMMAATEKDPRELLQLAVERILGEEALRYLK
>NC_012918.1|WP_012773752.1|49819_49999_-|hypothetical-protein
MKTCSICKKGYDENEPDTLYGEAGEWLAEELFKDAGELCRSCRENRARLVMMYGHDVNT

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_012918_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012918_3

370832-370904

Orphan

Consensus_repeat	Method
CAGGTCTTGAAATGTCACTTTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012918_3

>merge|NC_012918|3|370832-370904|CRISPRCasFinder
CAGGTCTTGAAATGTCACTTTTCCATACCTAGCTGTGCCCCTAGCTGTGCCAGGTCTTGAAATGTCACTTTTC

>NC_012918|3|3|370832-370904|CRISPRCasFinder
CAGGTCTTGAAATGTCACTTTTC	CATACCTAGCTGTGCCCCTAGCTGTGC
CAGGTCTTGAAATGTCACTTTTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012918.1\|WP_012774017.1\|379147_379339_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_012774012.1\|371435_372224_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_049760075.1\|380526_380805_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_012774011.1\|369155_370769_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|223963
NC_012918.1\|WP_012774009.1\|366879_367668_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_083776381.1\|366701_366857_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_012774010.1\|367664_369137_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340404
NC_012918.1\|WP_012774014.1\|374362_375088_-\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|319872
NC_012918.1\|WP_012774008.1\|365451_366306_+\|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl\|CDD\|223407
NC_012918.1\|WP_012774007.1\|364993_365452_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224501
NC_012918.1\|WP_157506084.1\|364455_364653_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_012774016.1\|377306_377852_-\|PEP-CTERM-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|377877
NC_012918.1\|WP_012774006.1\|363726_364008_+\|Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|372700
NC_012918.1\|WP_157506083.1\|364108_364285_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225765
NC_012918.1\|WP_012774018.1\|379384_380524_+\|DUF4388-domain-containing-protein	unknown	unknown	gnl\|CDD\|373017
NC_012918.1\|WP_012774013.1\|372563_374366_-\|aldehyde-ferredoxin-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|225277
NC_012918.1\|WP_043577561.1\|383440_386218_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|225114
NC_012918.1\|WP_012774005.1\|363373_363730_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|377579
NC_012918.1\|WP_012774015.1\|375389_377141_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|226702
NC_012918.1\|WP_012774019.1\|381142_383344_+\|catalase/peroxidase-HPI	unknown	unknown	gnl\|CDD\|237891

Protein	Function_ID	Function_description	E-value
NC_012918.1\|WP_012774014.1\|374362_375088_-\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|319872	cd10550, DMSOR_beta_like, uncharacterized subfamily of DMSO Reductase beta subunit family. This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.	2.75036e-44
NC_012918.1\|WP_012774011.1\|369155_370769_+\|radical-SAM-protein	gnl\|CDD\|223963	COG1032, COG1032, Fe-S oxidoreductase [Energy production and conversion].	2.30339e-05
NC_012918.1\|WP_012774013.1\|372563_374366_-\|aldehyde-ferredoxin-oxidoreductase-family-protein	gnl\|CDD\|225277	COG2414, COG2414, Aldehyde:ferredoxin oxidoreductase [Energy production and conversion].	0
NC_012918.1\|WP_012774010.1\|367664_369137_+\|hypothetical-protein	gnl\|CDD\|340404	cd16927, HATPase_Hsp90-like, Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains. This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.	8.42477e-08
NC_012918.1\|WP_012774016.1\|377306_377852_-\|PEP-CTERM-sorting-domain-containing-protein	gnl\|CDD\|377877	pfam07589, VPEP, PEP-CTERM motif. This motif has been identified in a wide range of bacteria at their C-terminus. It has been suggested that this is a protein sorting signal. Based on phylogenetic profiling it has been suggested that the EpsH family of proteins mediate this function.	2.08034e-06
NC_012918.1\|WP_012774008.1\|365451_366306_+\|SPFH/Band-7/PHB-domain-protein	gnl\|CDD\|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	2.25146e-54
NC_012918.1\|WP_012774007.1\|364993_365452_+\|hypothetical-protein	gnl\|CDD\|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	2.64068e-19
NC_012918.1\|WP_012774006.1\|363726_364008_+\|Fis-family-transcriptional-regulator	gnl\|CDD\|372700	pfam13744, HTH_37, Helix-turn-helix domain. Members of this family contains a DNA-binding helix-turn-helix domain.	1.44294e-06
NC_012918.1\|WP_157506083.1\|364108_364285_+\|hypothetical-protein	gnl\|CDD\|225765	COG3224, COG3224, Uncharacterized protein conserved in bacteria [Function unknown].	0.00190626
NC_012918.1\|WP_012774018.1\|379384_380524_+\|DUF4388-domain-containing-protein	gnl\|CDD\|373017	pfam14332, DUF4388, Domain of unknown function (DUF4388). This domain family is found in bacteria, and is typically between 102 and 135 amino acids in length.	9.34417e-17
NC_012918.1\|WP_012774015.1\|375389_377141_+\|GAF-domain-containing-protein	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	9.63723e-55
NC_012918.1\|WP_043577561.1\|383440_386218_-\|GAF-domain-containing-protein	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.99609e-57
NC_012918.1\|WP_012774005.1\|363373_363730_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|377579	pfam05973, Gp49, Phage derived protein Gp49-like (DUF891). This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.	3.41816e-26
NC_012918.1\|WP_012774019.1\|381142_383344_+\|catalase/peroxidase-HPI	gnl\|CDD\|237891	PRK15061, PRK15061, catalase/peroxidase.	0

>NC_012918.1|WP_012774011.1|369155_370769_+|radical-SAM-protein
MERILLVEPDYSNKYPPLGLMKLATYHKNRKDRVEFYKGKAPYTILNKIDRVYITTLFTFYYDITIETVKYYQDYIDNNNIFVGGIASTLLYDDFKNDTNLENIITGQLTCSSRIGYSDNINIDSLPLDYDILDDISYEYPSGDNFFIYTTRGCPRRCEFCAVSTLEPKFKETNHIISQITEIRDKFGDKRNVLIMDNNILFSSKLHETIDDLNAMGFQKNTPNYIYPNPIDILLKKIIRRKNNGNVTIKLEHVLYEFICNFKSKIKNFDTLSEYENIIKDMNISNVVDTVLKYRDNLFTIVEKYRYKKSLQRYVDFNQGADARLLTTAKMNILKNIPIKPFRLAYDNIEETESYFAAFEIAYDGGVRHFSNYILYNYDDKPEDLWTRLHNSIIMFEVKSDIQAFSFPMKYAPLKKSREYVGDYWNKKFLSAINVVINVTNGSVAKEKDFFYKAFGSNIAEYRKILTMPNEFIKHRFLFEENGLINQWETAYLSLTQEEKVILIEILSGERLAQDACHAVADILKYYRITKHMVLSQ
>NC_012918.1|WP_012774010.1|367664_369137_+|hypothetical-protein
MINNIFIGKSLLETITSALYENPIILFREYVQNSADAYKKAKNDGYASIDDFDINIKIDKSNACITITDNGYGIYTTADFEKKMINIAMSDKLDRSQYIGFRGIGRLSAMPFCNSLEFVNKKKGSAQLDKCKWDGSKYRNLLNSDATDLQSFFDIVKSIVEVSSEASDGAIDDHYFKVIIKGYSPEIAEVIESANFKQRLKKMLPLKYSDNFKASQKIIEKYNQFMSEAFNDFAYSVKLDGEELLKNYSDSKHVLESDIVFWEITGKAGPKKEPGEKIGIMWFTFNKKPIANNDDNDYGILVRSKNVLMGTNDTFADLCENSKEHISTYRELTQALRGVYGEMLINSTNLKDNARREWFKTDDNSYYLKCIIISFMKSLHLYRYKASKYFNNKGPENKKLLKEALINLVDIDTNNIDVNSFYDIEKSDDSNQDNDEIQSYLYATEDIPRQSKTKKKTYDELMVIIQEFFEKEGQFDMFLKLRAYVKKAFN
>NC_012918.1|WP_012774009.1|366879_367668_+|hypothetical-protein
MAKKKNVTIAGIDPDEWLSIDAHIDSTEEVVARKYDKKIIAFLDLLAMKDLILNKKRKPGEEIEAFEIIEQIKSIVEIETRSLDRDHNFVLLQLSDSFIFTCSDEDIAQLILLLGTIQMRILVECKFQLRGAITYGDVYIADEGKQIIGPAYIEAYLLQENNAIYPRIILSNAFVDRMGELNHTPSGVVLSADSEDFIDYLSIYLQTESKNRTDIITHLKRQNVFSFLQQHYNQYRSNNNYSVKQKYGWTISYFKNKGVWPK
>NC_012918.1|WP_083776381.1|366701_366857_+|hypothetical-protein
MMGQLLESAILEPVLVVNGKNRRPVVVMLSYREYGKLLSRSQEQLELAEGA
>NC_012918.1|WP_012774008.1|365451_366306_+|SPFH/Band-7/PHB-domain-protein
MEPAAIIFAILFFVVVVTIFMGVRLVPQGFEFVVQRLGKYHSTLKPGLNFIIPYVDIVAYRLTTKDIPLEIGAQEAITKDNAVIVANAIAFIKIVDPVKAVYGISNYEYAIQNLVMTSLRAIIGEMELDRALSSRDIIKARLKDIISDDVTDWGILVKSVEIQDIKPSESMQKAMEQQATAERLKRAMILEAEGKKEAMIREAEGKLEAAKKEAEAQMMLAEASAKAIQDIAVAVGDKELPALFLLGDRYVNAIQKLSASPNTKNFVLPADILGAVKGIAGRSV
>NC_012918.1|WP_012774007.1|364993_365452_+|hypothetical-protein
MDIVWWHWLTLGLILIGLELIVPSFTIIWFGLGAVIVSIVIALFPSFPFSAQILVWTVASSLSTFAWFRFFNARRDQTKAGSSKGAVIGETGLVIRAAQQYAKGAVKFHLPLMGADEWACVADEPLAVGDRVRVVDVEGHVMKVEKISKGDK
>NC_012918.1|WP_157506084.1|364455_364653_-|hypothetical-protein
MQIAQTGMQIAQTQMQMAQTQIGMAQTEMKMAQTEMEMAQTEMGIAQTQMEMVNLLGGIVKLDSE
>NC_012918.1|WP_157506083.1|364108_364285_+|hypothetical-protein
MTLIVPYLLAPLFVVATPLQSAYVKGLIIAAVIVALMTFVIMPRDTRLVKRWLYEEPD
>NC_012918.1|WP_012774006.1|363726_364008_+|Fis-family-transcriptional-regulator
MKDKHIGSNFDDFLEEEGLRADAEAAAIKRVIAHQIELEMKHANLSKTAMAEKMHTSRTALDRLLDPTNVSVTLQTLERAALALGKNLKVELA
>NC_012918.1|WP_012774005.1|363373_363730_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MASDAFVLKVVFYRSEAGNEPVRDWLKDLARDDKREIGEDIKTAQLGWPLGMPLIKKIDKGLWEVRTNLADGIARVFFTVDDEHMVLLHGFIKKSQKTPQNELKTALSRLGNFKRGTK
>NC_012918.1|WP_012774012.1|371435_372224_+|hypothetical-protein
MEVVERFDLQDKGDHTVVIKTITVKNHHIPLLFLPLIWFVTRFGKPVMPDRLKHLCESTEIPAAIAAAPPGLHGDIRQHTAGARTGYKVTLTKAQPFSLTGILLPLSIIISFGWMLANVITPISAAIVLFNANGYRQAVFTVENLYHEGRRRTGLQWGFSGTVAGTKERFFAPELARGESTSYLALEKRFPKGSKLAVLYNPGVTRDLFQARTIRVLPYNPDFAKQEERRIYWWLKYCLFPFVAVTVIASKLRGKQKGQTPT
>NC_012918.1|WP_012774013.1|372563_374366_-|aldehyde-ferredoxin-oxidoreductase-family-protein
MSGKPGYHGKILNIDLSTGKIETLPVPAEDFDKFVGGQGLGMKILWDRLKKPGVDPLSPDNLLMFMPGPFSGLPVPSSSRTCVVTKSPITSPLKSDHTHPSTVTYSNMGGFFGPEVRFAGYDGIVITGKARVLSYVVIDDDKVEIREAAKFKGMRTDAFDRAFLAELGDRRFKTVYIGPAGENLVPYSSILHTAGRAAGRGGTGCVMGSKNLKAIAVRGSGQPTVADHKAFLAALENARRALNGSAFAKSWAEQGTARAIVGNSNAGTEAVRNYREGTFTEADKIGGDAARRDVWVKDIACYCCPLACKKSGMTKGKYGGVVHDGPEYETGVMLGSNLMISDMPGLLKAITTIDDLGLDQISTGNVIGFLMEAYERGLINRSFLDGIDLKWGSVDATLAMIEKIAAKEGVGALAAEGVRALSWHIGKGSEKFAIQVKGLELAAHNIQANQPRGLSYVTASRGACHMSGDDIAMQNRRAMMDSTGMCFFPTFEPTLEEPMLALLSAITGRKFDKAEFEKVGERIFNLEKLFNYREGFRREDDRLPDRFFEDAFTVGPKKGAVLDREKFESMLTKYYQDRGWDPETTRPGKKKLKELGLESI
>NC_012918.1|WP_012774014.1|374362_375088_-|4Fe-4S-dicluster-domain-containing-protein
MDKGKIESCGSYDSTTLTRREFIKGVGIGGGALVLFGHFGVHSAAWALAGDPALNMVLVDYAKCTGCRTCETACSSRNRPVSLKGRELPGLGNPRFANIRVHSFNPDVDVPNVCAMCADTPCVKACPVEPDPKTGRRALYRDNATQTVQNDSDRCLGCRSCAKACAAQRTGVITPDTATGKPERMCTLCGGDPQCVKRCPFGALSCVEVRRDRKFYGLGPKQIAAELAKTWYGTADFGGLK
>NC_012918.1|WP_012774015.1|375389_377141_+|GAF-domain-containing-protein
MATEELLQDLKKRGELDERHLLASIRLLHLLASGKSSQEVMSTLLPFFQELSGCEAVAVRLREEEDYPYFQTVGFTQEFVNAESHLCVKDLAGQIKRDEIGHPVLECMCGNVLCGRFDDSKPFFTPNGSFWTNSTSELLESTTEEERQSGTRNRCSAEGYESVALVPLHHNEDIIGLIQFNDRRKDRFSKGFIALVEMLADSVTVAVLRRWEEESLRKREEYYRAMVTAFDGLIYICSANYRIEFLNEAMKRRIGHDAIGELCYEALHGLDAVCPWCKNDRIFAGESHRWVVQSPKDNRWYEVSNTPIRKNNKIVSKQAMIVDVTDRQQLHEDLLQKQQDLMSANDLLESRVAERTSNLEAAMREHESFSYSVSHDLRAPLRHINSFSAIVMEEFGNELPPPVKDYLVRIRSASNRMGGLIDHLLELSRVGRAALKLEPVDLSEMAASILTALQETELKRTVKIFVEEDVRVLGDRTLLQQLLQNLLGNAWKYTSKTVSARIEFGSSKRGDSTVNYVKDNGAGFDMQYKDNLFIAFQRLHTAEFEGEGIGLTTAQRIIHRHSGDIWAEGEVGKGATFYFTLPD
>NC_012918.1|WP_012774016.1|377306_377852_-|PEP-CTERM-sorting-domain-containing-protein
MKSLFVVASLICGLGFFAPSAHATLLDGKTVSGEYLFSTMNSVYQNFGNVTVGSGVEFFNLGNIPVTLDISDTQLINRFGLATSWNAAPFNGYHISDVNNTIADFTSVSIDPSTNMAGLDLSRVTFDANNIWVNWNGLSFNNNTLVVLDVDGAAPVPEPSTIFLLGAGLAGLGIVRRRAKS
>NC_012918.1|WP_012774017.1|379147_379339_+|hypothetical-protein
MKMSKIGLVALLICSVAAGVSGCKKEGPAERAGKEIDRSVEKAGKEFEKAGNKIDNIIKEINK
>NC_012918.1|WP_012774018.1|379384_380524_+|DUF4388-domain-containing-protein
MSLEGNIEDIGLGEILQFVSLSRKSGVMSLVSRGRKARIIFQNGQVTRASSTTCIQQIGEVLIHEGVIDLDILQRALSIQVEERYTQLLGTIMVERFDVSPEAIDKVVTEQIEKVVYSLFTWTKGTFTFEFQEVAEADAVRMDPIEFMLKQGLNPQFLAMEGSRLIDEKRHLGELDEEPEEAAAPVPAPDSGFDRACTKSCAPEEPAVPPSTEETVDPFEHELSPSAKTTAVVIMALGTAILVYGVAGLIDYYSRGWQAALPDPDLVMVSKLSIFFWFGFIPWVVTLFGLYLVGAAYQVLKGRNSYRRLIECAWSGVAVAVIYEAVEFGNWVKLASSTPTASFYAIGIVGSVLYAALLSAPFAGLLFYLKGNHTSRRNS
>NC_012918.1|WP_049760075.1|380526_380805_+|hypothetical-protein
MSPMQVIFRELGSNGVYLASLNKWIRADARGNTGSIDARFSIDSEQLAFDMDPTAGEFIYDTIFAAPAGSVVDKLRKYDTRSELWLDLPRAF
>NC_012918.1|WP_012774019.1|381142_383344_+|catalase/peroxidase-HPI
MSTDSQCPVTGRANKHAARVGRMNRDWWPNQLNLKILHQHSPLSNPMGGNFNYSEEFKALDLAAVRNDIFELMTNSQDWWPADYGHYGPLFIRMAWHSAGTYRTGDGRGGARSGSQRFAPLNSWPDNANLDKARMLLWPIKQKYGKKISWADLLIFAGNCALESMGFKTFGFGGGREDIWEPGEDIYWGAEDTWLGDKRYSGERLLENPLAAVQMGLIYVNPEGPNGNPDPLAAAKDIRETFARMAMNDEETVALIAGGHTFGKCHGAGAATHVGPEPEGASIIEQGLGWKCSLGTGRGEHTITSGLEGAWTTNPVKWDNGFFDVLFSYDWALAKSPAGAHQWIPTDPAAKGTVPDAHNPAKRHAPMMLTTDLALKLDPIYGPISKRFHEQPDLFADAFARAWFKLTHRDMGPRACYLGPEVPAEDLIWQDPLPARNHELIDDQDIAELKGKIVTSGLSVSQLVSTAWASASTFRSSDRRGGANGARIRLAPQKDWEVNQPAQLKLVLETLEGIQKQFNSAQSGGKRVSIADLIVLGGCAAVELAARNAGHEIIVPFTPGRTDAAQEQTDVVAFAPLEPAADGFRNYLKTRYSVSAEELLVDRAQLLTLSAPEMTVLIGGMRVLDANADRSRHGVFTRRPGTLTNDFFVNLLDMGTTWNATSEAEDVFEGRDRVTGEMKWTGTRVDLIFGSNSLLRAQAEVYGCKDAQEKFVVDFIAAWSKVMNLDRFDIANS
>NC_012918.1|WP_043577561.1|383440_386218_-|GAF-domain-containing-protein
MDQQLKKLGDRIASFGKENLDEMLHLVGEGSRLISGQERVRIYLEDLTKGALSCAFSCGGFATEIRQETFPIISAEAAVSRTFVTQQVAQYQNPAETGLPLDQEFSRRFQIEGTTMLPITSQGKSIGVACLDGSTLSQDKIDELIPFLARAGERVDQARKYHQQLLLARRVELYKRREAAGFMVRSAVNLIDGLTLASVLVPVKGGMEVLASHAQDPDLKYLYDNVGGIDLKHGTSLVSRYVNEAGVVTDPSLLKPMFFPDLLDQSIQRRALTEEMGLRTLYMVPRVEPETKRIICLMNYFTRDVTNYTDFEMGLLQTHAEMVERVINEVGGEHLEIKVLSEISDLLQEPNEGLHGFLTKVLSKATELIGADTGSIAIVQEREGVKWLVVENEEGTIVGAKNKEWLKKKIPPFKIGGADLPPEERSLTGYVAWTKEPKIIEQVADQSRHEGFHRPMNELIQSEMAVPVISDDEVIAVICLNSLQDGYFTEEHKRILQIIDRLTSRHISDIQRIERLQSEVNKLQSDIAYKDPKVSSYRLGNIIGNSRKSQEIVAFINTVAQPLSNRIALWSRNILQEATIGLPSILVLGPTGAGKEFFFNNLYNKLNELYRQQINPDGELPVKKTNIAAYSGDLTYSELFGHIKGAFTGAYSDRKGIIEEAAGGIVFLDEIGDADPKTQVQLLRFLDNGGFVRLGENRERISRVLLVAATNKDLSKEIAMGNFREDLFHRLTELSVVVPSLNERREDIPDLSIHFLGKLYRTYRSREEEARDAEPSLSKDAKDALVSHNYKGNIRELRSILLRALFFRTGKMVTGEDIKKAIRDGMREQMTPAAERLSEEVAGGILAEIEAGSDFWEAVYQPYSQSRISRDVVRLIIEKSRVAAGKNMPEIARYLKAITGDPQEDEEERKRFFRFKNFLYKTVKI

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_012918_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012918_4

582201-582293

Orphan

Consensus_repeat	Method
AAGATGAAGATAAAGATTGAGAAAAATCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012918_4

>merge|NC_012918|4|582201-582293|CRISPRCasFinder
AAGATGAAGATAAAGATTGAGAAAAATCACTTCTCAGTGTAGGAGATCATCTACCGGTAAAACCGAGATTAAGATAAAGATAAAGATTGAGAA

>NC_012918|4|4|582201-582293|CRISPRCasFinder
AAGATGAAGATAAAGATTGAGAAAAATCA	CTTCTCAGTGTAGGAGATCATCTACCGGTAAAACC
GAGATTAAGATAAAGATAAAGATTGAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012918.1\|WP_012774180.1\|585383_586601_+\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NC_012918.1\|WP_012774185.1\|591399_591867_+\|bacterioferritin	unknown	unknown	gnl\|CDD\|153099
NC_012918.1\|WP_012774172.1\|576004_576184_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|283241
NC_012918.1\|WP_012774176.1\|580646_582170_+\|mercuric-reductase	unknown	unknown	gnl\|CDD\|235787
NC_012918.1\|WP_012774169.1\|571709_572693_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270229
NC_012918.1\|WP_043578343.1\|576833_577727_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_012774170.1\|572697_575040_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226951
NC_012918.1\|WP_012774186.1\|592027_592471_-\|PAS-sensor-domain-containing-protein	unknown	unknown	gnl\|CDD\|272971
NC_012918.1\|WP_012774178.1\|583247_584303_+\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NC_012918.1\|WP_012528889.1\|576360_576552_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_012774168.1\|570552_571431_+\|M48-family-metalloprotease	unknown	unknown	gnl\|CDD\|320692
NC_012918.1\|WP_012774179.1\|584304_585267_+\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NC_012918.1\|WP_012774177.1\|582406_583081_+\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NC_012918.1\|WP_012774173.1\|576613_576763_+\|lmo0937-family-membrane-protein	unknown	unknown	unknown
NC_012918.1\|WP_012774175.1\|577831_580393_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NC_012918.1\|WP_012774183.1\|589058_589688_+\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
NC_012918.1\|WP_012774171.1\|575050_575701_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_012918.1\|WP_012774184.1\|589754_591032_+\|uracil-xanthine-permease	unknown	unknown	gnl\|CDD\|225142
NC_012918.1\|WP_043577594.1\|588065_588890_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|366759
NC_012918.1\|WP_012774181.1\|586769_587861_-\|Glu/Leu/Phe/Val-dehydrogenase	unknown	unknown	gnl\|CDD\|223411

Protein	Function_ID	Function_description	E-value
NC_012918.1\|WP_012774180.1\|585383_586601_+\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	2.16758e-180
NC_012918.1\|WP_012774172.1\|576004_576184_+\|CsbD-family-protein	gnl\|CDD\|283241	pfam05532, CsbD, CsbD-like. CsbD is a bacterial general stress response protein. It's expression is mediated by sigma-B, an alternative sigma factor. The role of CsbD in stress response is unclear.	0.000967405
NC_012918.1\|WP_012774176.1\|580646_582170_+\|mercuric-reductase	gnl\|CDD\|235787	PRK06370, PRK06370, FAD-containing oxidoreductase.	0
NC_012918.1\|WP_012774169.1\|571709_572693_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270229	cd01008, PBP2_NrtA_SsuA_CpmA_like, Substrate binding domain of ABC-type nitrate/sulfonate/bicarbonate transporters, a member of the type 2 periplasmic binding fold superfamily. This family represents the periplasmic binding proteins involved in nitrate, alkanesulfonate, and bicarbonate transport. These domains are found in eubacterial perisplamic-binding proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates. Other closest homologs involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB) are also included in this family. After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. These binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.59886e-38
NC_012918.1\|WP_012774170.1\|572697_575040_+\|PAS-domain-containing-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	4.83485e-42
NC_012918.1\|WP_012774186.1\|592027_592471_-\|PAS-sensor-domain-containing-protein	gnl\|CDD\|272971	TIGR00229, Sensor_protein_FixL, PAS domain S-box. The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions].	2.18072e-17
NC_012918.1\|WP_012774178.1\|583247_584303_+\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	9.29417e-173
NC_012918.1\|WP_043577594.1\|588065_588890_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|366759	pfam01694, Rhomboid, Rhomboid family. This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.	7.11061e-18
NC_012918.1\|WP_012774168.1\|570552_571431_+\|M48-family-metalloprotease	gnl\|CDD\|320692	cd07333, M48C_bepA_like, Peptidase M48C Ste24p bepA-like, integral membrane protein. This family contains peptidase M48C Ste24p protease bepA (formerly yfgC)-like proteins considered to be putative metallopeptidases, containing a zinc-binding motif, HEXXH, and a COOH-terminal ER retrieval signal (KKXX). They proteolytically remove the C-terminal three residues of farnesylated proteins. They are integral membrane proteins associated with the endoplasmic reticulum and golgi, binding one zinc ion per subunit. In eukaryotes, Ste24p is required for the first NH2-terminal proteolytic processing event within the a-factor precursor, which takes place after COOH-terminal CAAX modification (C is cysteine; A is usually aliphatic; X is one of several amino acids) is complete. Mutation studies have shown that the HEXXH protease motif, which is extracellular but adjacent to a transmembrane domain and therefore close to the membrane surface, is critical for Ste24p activity. Several members of this family also contain tetratricopeptide (TPR) repeat motifs, which are involved in a variety of functions including protein-protein interactions. BepA has been shown to possess protease activity and is responsible for the degradation of incorrectly folded LptD, an essential outer-membrane protein (OMP) involved in OM transport and assembly of lipopolysaccharide. Overexpression of the bepA protease causes abnormal biofilm architecture.	7.51138e-58
NC_012918.1\|WP_012774179.1\|584304_585267_+\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	0
NC_012918.1\|WP_012774177.1\|582406_583081_+\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	1.92371e-26
NC_012918.1\|WP_012774185.1\|591399_591867_+\|bacterioferritin	gnl\|CDD\|153099	cd00907, Bacterioferritin, Bacterioferritin, ferritin-like diiron-binding domain. Bacterioferritins, also known as cytochrome b1, are members of a broad superfamily of ferritin-like diiron-carboxylate proteins. Similar to ferritin in architecture, Bfr forms an oligomer of 24 subunits that assembles to form a hollow sphere with 432 symmetry. Up to 12 heme cofactor groups (iron protoporphyrin IX or coproporphyrin III) are bound between dimer pairs. The role of the heme is unknown, although it may be involved in mediating iron-core reduction and iron release. Each subunit is composed of a four-helix bundle which carries a diiron ferroxidase center; it is here that initial oxidation of ferrous iron by molecular oxygen occurs, facilitating the detoxification of iron, protection against dioxygen and radical products, and storage of ferric-hydroxyphosphate at the core. Some bacterioferritins are composed of two subunit types, one conferring heme-binding ability (alpha) and the other (beta) bestowing ferroxidase activity.	6.31556e-70
NC_012918.1\|WP_012774175.1\|577831_580393_-\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	1.91208e-114
NC_012918.1\|WP_012774183.1\|589058_589688_+\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	3.8372e-123
NC_012918.1\|WP_012774171.1\|575050_575701_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.81721e-71
NC_012918.1\|WP_012774184.1\|589754_591032_+\|uracil-xanthine-permease	gnl\|CDD\|225142	COG2233, UraA, Xanthine/uracil permeases [Nucleotide transport and metabolism].	9.48864e-121
NC_012918.1\|WP_012774181.1\|586769_587861_-\|Glu/Leu/Phe/Val-dehydrogenase	gnl\|CDD\|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	2.87073e-112

>NC_012918.1|WP_012774176.1|580646_582170_+|mercuric-reductase
MRDQLVFQPDTAENRELETNVRPGGWRNPVPSGRYNLVVVGAGTAGLVCAAGAASLGARVALVERLALGGDCLNVGCVPSKALIRASRAVFDARHGGDFGVVGGETLQADFAAALQRMRRLRAGISRHDSALRFRDELGVDVYLGQGTFTAPDTLQVAGATLRFARAALCTGARAAIPPVPGLEEARCLTNETVFSLTSLPARLAVIGSGPVGCELAQAFARFGSKVTLVERGAGILGREDRDAAAILETVFRREGVELELGAKLVRAWSSGSEKRLLLERDGKAFEIAADAILVGAGRAPNTEGLGLEAAGVEYGKTGVTVNDYLRTSNRRIYAAGDICSGYKFTHLADAQARIVIENSLFPGRKKNSGLTVPWCTYTDPEVAHVGMYEADALARGLKVETLTIPFGDVDRAVLDGESEGFARVHLKKGRDVILGATIVARHAGEMIGEIALAINAGLGLSAIGRTIHPYPTQAESLRKLADSYNRGRLTPSVKKLMGAWLSWQRK
>NC_012918.1|WP_012774175.1|577831_580393_-|EAL-domain-containing-protein
MIDADSKNAGNRSRDRNDFDSDNVSLSTEELVRELQVYTDLYEFSPVGLFTLDAAGNIRSVNNTGAGLLGKPRPELVGVPFEQAVAEPSKGDFSVLLNDARTSQSKSACELTLVSASSRQLPVRIDALCCKEGTEYRLSVLDITKRKQSELALQRSEARYRRLFETAKDGIMIVEADSGAIAEVNPFLVDMLGCRRDELLGKTVWELHFFAHVVPGAADFKAMQQKEFFHGDDLQLATVRGRDIPVEVVSNCYQSEQSSVVQFNIRDISIRKNAEQALLSSEEQCRTIVSNINEYVYSVRFEEGDITSVYHSPKCFDITGYTPEEYYRDPLLWFTMIHEEDRNLVVEFLNGIFAGLDHEPIRHRIIHKDGSVRWIVNNCAVQRQRRGDRLSITRLDGFILDVTDIKRAEENIFFLAHHDPLTKLPNRSTLYERMEQVICAAQKSSRNVALLFLDIDGFKQINDSMGHDVGDRLLQSVAKRLSDCTRSCDVVSRLGGDEFVVMLWDCGEAETTVVAEKVINAGFPVLGSNVTVTPSIGISIFPDDGRDYLTLLKHADIAMYHAKKSGGNNFQFFTHKLNEIAHERFMLEAELRRALDREEFVLYYQPKVDLSTGKFSGMEALIRWQHPAHGLMLPESFIGIAEESGLLTQISKWIIPTVCRQIQQWQQQGINSVSAAVNLSASFFQHPDFEETIEESLLQTGIAPECLELELTEATIMSDPQRVLGSMAAMKALGLQLSIDDFGTGYSSLSYLKKLPVDKLKIDQSFIHNIARDADNAAVVRAVISIGRSMQLRVIAEGVENASQLAWLQAEGSEEAQGYYFSRPLPVAKMTSLLKQGANFLHNPRGKTQAKTL
>NC_012918.1|WP_043578343.1|576833_577727_+|hypothetical-protein
MRVTAAVITVLALAAVPCFAANGGATAGRAGGTGAAATMHQVPPGQQMNQETMPTPAHLLMRAYHRNVANFAQTLYQATDQGPVVPAPLARTAVSEMRRSVDEMEKQRATALGAMRLPPERQKMMDEHLVQVKTHLRQLEELVQKERIDSGLVKKELQSIFAECDGARCGARPSPMGRGRQGKGPYGGRPGCDCPKGNPDHSMMMDDMMEKVKSQDAELARMVQRMRQADGQAKLDLVAETVATMVQQRAELTAEMQKMHDMMQGESPGPDQMMNDDEDQGEDEEYDFQDEEEVTAD
>NC_012918.1|WP_012774173.1|576613_576763_+|lmo0937-family-membrane-protein
MLWTIVVILLILWLLGLVTSYTLGGFLHLLLVLAIIVVIINLIQGRRPL
>NC_012918.1|WP_012528889.1|576360_576552_+|hypothetical-protein
MPLIQVLLVLIVVGVLLWLVNTYVPMAGSIKSILNAVVVIVVVIWLLNVFGLMENITRLRVGK
>NC_012918.1|WP_012774172.1|576004_576184_+|CsbD-family-protein
MKPSTKDQTKGKLHELKGQVKEEAGNISRNVSMEHQGRAEKVAGKVQKSAGKAEKKTDK
>NC_012918.1|WP_012774171.1|575050_575701_+|response-regulator-transcription-factor
MSMKVLIVDDHTIVRQGLRVLIDKEQDMEVIAEAATGAEAIRIAREKRPDVTVMDITMPDLNGIDATRAIVAEWPQARVLALSMESDRRFVVEVLKAGANGYVLKDSAFAELATAIRAVASGETYLPSRVTTLLIKEYLQRIPDEVPATYENLSLREREILQLIADGKNAKEIAFSFGVSVKTVENQRHSIMKKLDLFSIAELTKYAVRQGLTSLN
>NC_012918.1|WP_012774170.1|572697_575040_+|PAS-domain-containing-protein
MTFAERMKISSILFFSLLVFGAVLLFWSSRELNSARQNDVLSDDIQTIVFERATLRDEYFLYGLERARVQWFALNRDAEESIRRGTLHLRAGEERQALEKVQADLRESVLVSQRLVELLRGKSGTELERAHHDDLASRLYSQIMLKDSALQQSSAALQQLTRRRFDRANFRTVFLTFVFVLSVVAGGRANAFFINSLLRRRLQLLNEGVARIASGDFSHRMECRGSDELAHLAGVFNGVLDRVQDYTGQLEKSHDLLNGLSSQVPGILFQACLTPAGLFSTPYVSRHVDELFLGDAVVPPQAPAQLFERFHAEEYQAILGTFQHSAETLEPWEYAFRINVPDGGIRWLRGQARPMRLSDGGTLWHGFISDITESKRAEEAQHRSESRYRLQLQELTNIYTHTAVGLLAVDREMRYLRLNEQMACYNCRPMDEHIGKTIDEVHPPRFVAVLKEMWRPVLERGESLLNLEVQGQADWPSGLRHWLVSFQPLFAETGAVIGLTGSVMDITERKVAEQVLLGARQQLEREVRLRTAKLSLVNQHLLREIEVRKKIEVELLAQQQKLQEMAFEISMAEERERDRIASELHDQVGQRLILAKIKLDSLASNLPLGECEAEAVGVETLIEQTLQDIRSLTFQIRPPLLATAGLEAALRWLGEELHADFGLEVEFSVDGKDKPLRYEVRSTVFQAVRELLLNVAKHAGTKKCRVRYTRVGDRIVMEVEDDGAGLKTGAGDGSRARSGGFGLLNVRQKIGHLGGVFSIESRPQGGTRAAIEVPVETETK
>NC_012918.1|WP_012774169.1|571709_572693_+|transporter-substrate-binding-domain-containing-protein
MRRAAIVLILSLLILGCRSKTPAEPVKPLALRLAYTTKHHSALVHLAAAKGYFQAEGVLLQPMLFEFGKQALAAVSEGKADLATVSETPFVLAALNGQRLSLVASIFTSWKNNGIVARGLASPRDLRGKRIAYTPGTTSEVFLDSFLMSLRIARQEVTLVALAPQQIPAALAAGEVDAASTWNPTLKEAATGLRGAGSVFFDPYLYTETFVLAGNRGYVDANRELMQRVLRALLKAEAYASKHPAEARTLMADAMKLTPELLAEFLDESRLRVSLDRSLLLSLEEESRWALRRKLAPEGAIPNYLEYIDVRPLQEVKPEAIEINIRR
>NC_012918.1|WP_012774168.1|570552_571431_+|M48-family-metalloprotease
MKQIIMSLFLALACLCSVEAHAGWQDKLQNLMNPESKEGKILSGATQVVSSSQEMTYATERTVGQSLALESMQRFGRPVPNEALQKYVNLVGNAVAKNSRRSTIPYQFVVLDSPVRNAFAAPGGMVFVSRGLLAVVENEAELAAVLAHEVGHVAEKHALKSIRRAQFLQGVGTISAATMKGSEGKKFESMIGDLQSTLFDKGLDQGMEYEADLAALETTYRTGYDPAAMVSVLRKLKKLEASDSGKGSWFSTHPPLDERIARLSARLEKYPDHASLAKVPARFAKSVKKAKK
>NC_012918.1|WP_012774177.1|582406_583081_+|TVP38/TMEM64-family-protein
MNLKKILILVAAVIAVTLFFYLDLGRYLTLESLKANRQALIQYYAAHEAATVAGFMALYILQTALSLPGAAILSLAAGAIFGSLAGTFYAVVAATVGATLAFVVTRYLLRDLVLDRFGPKLEGLNRELETRGFNYLLFLRLVPLFPFFLINLAAGLTRLPLRVFVPGTLIGIIPGGFVFVNAGASLATIDSLSDVASPRVLGSFALLGLFALVPVIYGKIKKKA
>NC_012918.1|WP_012774178.1|583247_584303_+|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MPEEILATFQVKRLSVLNENGSADLALMPELSADQIRRMYQLMVLSRCFDERAVSLQREGRLGTYPPIRGQEAAQVGSAFALQPNDWVFPSFREMGAHLTLGYPIPQLLQYWTGDERAQKAPPQLNIFPFCVAVGSQIPHAVGAALAARYRRDSAAVAVYFGDGATSKGDFHEAMNMAGVYQLPIVFICQNNQWAISVPLKGQTASASLAQKALAYGFEGVQVDGNDVLAVYRATKQALEKARSGGGPTFLECLTYRMADHTTADDAGRYRSDEEVALWNGRDPILRLERFLAASGAWTPEQGRWAKEEATALIDRGVREMEAVPPPAASELFDGTLAALTPRQAGQREGR
>NC_012918.1|WP_012774179.1|584304_585267_+|alpha-ketoacid-dehydrogenase-subunit-beta
MAQLNMVQAINQALGDEMARDDRVVLLGEDVGRDGGVFRVTEGLQDRFGAERVLDTPLCESAIMGAAIGMAAYGLRPVPEIQFMGFTYSAFEQLFAHAARLRSRSRGRYSCPLVVRTPYGGGIKAPELHEESTEAIFCHIPGLKVVVPSGPYSAKGLLLAALRDPDPVLFLEPTRLYRMLKEEVPEGDYQLELGKARVARKGSAVTVVAWGSMLERVLKSVDGYDVEVIDLLTLNPLDLETLLSSVQKTGRAVIVHEAIKTCGLGAEIAATLAEEAMLHLRAPILRVTAPDVPVPLAKLIDQYLPGPQRIRAALDEVLKY
>NC_012918.1|WP_012774180.1|585383_586601_+|2-oxo-acid-dehydrogenase-subunit-E2
MSIDFKLPDLGEGIAEVELRRWLVAEGDAVAEHQPLVEVETDKAVVEVPSPRSGVVARLHRKEGETVQVGATLVTFAEAKEAGRREEPEGERRPAQRPPSVGIVGSLPEPEAATQAPPAGFEGLATPMVRKMARERGIDLKSVRGTGPRGCIKPEDLDQIPQSAQKAKPAPQDGERVPLRGLRRTIARNVLASQKTTAFVTSMEEVDITDIWEMRGREQGEVESRGAHLTFLPFFIKAVQHALREHPLLNGSIDDEAQELVLKKQYHFGIAVDTPEGLMVPVIRDVDKKSIIELAQAVQELGRKARERSISLEELRGSSFTITNYGHFGGTFATPIINWPDVAIMGFGRIVERPWVHRGQIAIRKILPLSLTFDHRATDGADAARFLGKVLRYLEDPALLFLDSA
>NC_012918.1|WP_012774181.1|586769_587861_-|Glu/Leu/Phe/Val-dehydrogenase
MPEIQFDDFGPCKVIQLYSPKEGVRGIVVIDNVALGPAVGGVRVSPTVTTEEVRRLARTMTLKNSIAGLPHGGAKAGIVADPADPRKERIFRVFARMIRDLADYIPGPDMGCDETSMAWIRDETGRAVGLPEEIGGLPLDRLGATGYGVAECAEVAARFANLELKGARVAVEGFGSVGKAAARFLVAKGALLVAASDTQGGVHDPAGIEVGELIEAKRRHGSVAGFGKGSRMDASDLFGVPCDILVPAAAPDVINSGNVDRIKARIVLQGANIPATAEAEQRLQERGVLVVPDFIANAGGVIMAAMEYAGKNEAEAFAAISERIKRNTARVLEQATGEGTLPRVAADALARERVRKAMGYRDY
>NC_012918.1|WP_043577594.1|588065_588890_+|rhomboid-family-intramembrane-serine-protease
MSSTTCSRCGRQIDARQAQCMWCGAPRPSFGARFREMLRGGLDAGLVVQGIIAANVLFYLLSLLLSGRRGFDMNPLSFMSPDQNSLLLLGATGTIPVLELGRVWSLISASYLHGGLLHILFNMMALRQIGPWVSAEFGASRMFVIYTLSGVAGYVASFFAGIPFTIGASASVCGLIGALFYFGKSRGGNYGAAVSREVSGWLISLVLFGLIMPGINNWGHGGGVVGGIVLAKLFGYEERSRENSAHRLLALICLVATVAVLCYAAYFSLAYRFK
>NC_012918.1|WP_012774183.1|589058_589688_+|uracil-phosphoribosyltransferase
MSVHEVNHPLVKHKIGLMREAGISTKKFRELTSEIASLLAYEASRDFQIEPRTITGWDGSKVGIQQLKGKKVTVVPILRAGIGMLDGVLDMIPNAKVSVVGLARNEETLEAHTYFERFVGNLDERLALIIDPMLATGGSMAATIEMLKNNGCLQIRVLCLVAAPEGLARITAAYPEIDIYVAAIDERLNEQGYILPGLGDAGDKIFGTK
>NC_012918.1|WP_012774184.1|589754_591032_+|uracil-xanthine-permease
MSEVKEPVWRQALSGAQILFVAFGALVLVPILTGLNPSMALLGAGVGTLIFQLCTKREVPIFLGSSFAFIAPIIYSVQTWGMPATLGGLFAAGWLYLALSLLIYLRGADFVHRIMPPVVVGPIIMVIGLGLAGVAVNMAMGKTGDGKGVLVDYETAILVAAVSLATTVAVAVRAKGIFRLLPVLSGVAVGYVLSIFLGLVDFTKIAAAPWIEVPTFVTPQFNWAAVLFMIPVALAPAIEHVGDVVAIGAVTGKDYTVKPGLHRTMLGDGLAVCTAALIGAPPVTTYAEVTGAVMITRCYNPVIMTWAAGFAIVMAFFGKFNAILQSIPVPVMGGIMMLLFGSIASVGLNTLIHAQVDLHRPRNLVIVSLVLVFGIGGLSLNVAGQHLHGVSLCGIAAILLNLVLPKGEAPPMGVETDEAEPETVP
>NC_012918.1|WP_012774185.1|591399_591867_+|bacterioferritin
MKGNERVIEQLNVRLAEELTATNQYMVHAEMCENWGYKRLHAKIRERAIVEMKHAEKLIERILFLEGRPIVSRLDPIHIGGEIPKMHQFDHALEETAIKGYNESIRIAVELGDNGTRELLQSILKQEEEHIDDIEAQLDQIAQMGVQNYLVDQVG
>NC_012918.1|WP_012774186.1|592027_592471_-|PAS-sensor-domain-containing-protein
MTQLQDDELHRQLVQECNDAIIFSDRQGVIRLWNKGAERMLGFTAEEAIGRSLDIFIPENQRARHWEGYFRVMETGFTHYQTDLLAAPALRKDGTRISTEFSMTIIRDADGQVAGTAAVMRDVTAKWQKEKSLRARVAELEMESGKS

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Crispr_ID: NC_012918_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012918_5

1658290-1658408

Orphan

Consensus_repeat	Method
CAGGGATTATATTCCCTCGGGCGACCGGGCGAGGCTATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012918_5

>merge|NC_012918|5|1658290-1658408|CRISPRCasFinder
CAGGGATTATATTCCCTCGGGCGACCGGGCGAGGCTATTGCGTCTGCCATATGGGAGGTTCATCGGGGAATACGGGGGACCAGGGATTATATTCCCCCGGGCGACCGGGCGAGGCTATT

>NC_012918|5|5|1658290-1658408|CRISPRCasFinder
CAGGGATTATATTCCCTCGGGCGACCGGGCGAGGCTATT	GCGTCTGCCATATGGGAGGTTCATCGGGGAATACGGGGGAC
CAGGGATTATATTCCCCCGGGCGACCGGGCGAGGCTATT

Protein	Signature genes	Signature genes Name	Protein_function
NC_012918.1\|WP_015836714.1\|1650921_1652007_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|236901
NC_012918.1\|WP_015836723.1\|1663005_1664193_-\|cardiolipin-synthase-B	unknown	unknown	gnl\|CDD\|234967
NC_012918.1\|WP_015836710.1\|1647978_1648392_-\|response-regulator	unknown	unknown	gnl\|CDD\|223855
NC_012918.1\|WP_157506124.1\|1668933_1669341_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015836720.1\|1658569_1659223_-\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|273175
NC_012918.1\|WP_015836719.1\|1656801_1658151_-\|replicative-DNA-helicase	unknown	unknown	gnl\|CDD\|273206
NC_012918.1\|WP_015836712.1\|1649012_1649846_+\|NAD-dependent-protein-deacetylase	unknown	unknown	gnl\|CDD\|223915
NC_012918.1\|WP_015836724.1\|1664293_1664515_-\|NifU-family-protein	unknown	unknown	gnl\|CDD\|376458
NC_012918.1\|WP_015836718.1\|1655233_1656517_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015836728.1\|1667330_1668488_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|224481
NC_012918.1\|WP_015836715.1\|1652218_1653655_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_012918.1\|WP_015836713.1\|1649963_1650929_+\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NC_012918.1\|WP_015836725.1\|1664709_1666110_-\|aspartate-ammonia-lyase	unknown	unknown	gnl\|CDD\|237031
NC_012918.1\|WP_015836711.1\|1648520_1649003_+\|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl\|CDD\|237976
NC_012918.1\|WP_015836722.1\|1660476_1662828_-\|endonuclease-MutS2	unknown	unknown	gnl\|CDD\|234750
NC_012918.1\|WP_015836716.1\|1653727_1654291_+\|hydrolase	unknown	unknown	gnl\|CDD\|238494
NC_012918.1\|WP_015836717.1\|1654274_1654988_-\|response-regulator	unknown	unknown	gnl\|CDD\|381099
NC_012918.1\|WP_015836721.1\|1659274_1660195_-\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NC_012918.1\|WP_015836726.1\|1666136_1666601_-\|ferritin-family-protein	unknown	unknown	gnl\|CDD\|153104
NC_012918.1\|WP_043578523.1\|1666701_1667334_-\|HAD-hydrolase-like-protein	unknown	unknown	gnl\|CDD\|223943

Protein	Function_ID	Function_description	E-value
NC_012918.1\|WP_015836714.1\|1650921_1652007_+\|PAS-domain-containing-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	1.65218e-93
NC_012918.1\|WP_015836723.1\|1663005_1664193_-\|cardiolipin-synthase-B	gnl\|CDD\|234967	PRK01642, cls, cardiolipin synthetase; Reviewed.	5.41306e-102
NC_012918.1\|WP_015836710.1\|1647978_1648392_-\|response-regulator	gnl\|CDD\|223855	COG0784, CheY, FOG: CheY-like receiver [Signal transduction mechanisms].	1.05259e-15
NC_012918.1\|WP_015836720.1\|1658569_1659223_-\|DNA-repair-protein-RecO	gnl\|CDD\|273175	TIGR00613, DNA_repair_protein_RecO, DNA repair protein RecO. All proteins in this family for which functions are known are DNA binding proteins that are involved in the initiation of recombination or recombinational repair. [DNA metabolism, DNA replication, recombination, and repair].	9.79371e-49
NC_012918.1\|WP_015836719.1\|1656801_1658151_-\|replicative-DNA-helicase	gnl\|CDD\|273206	TIGR00665, DnaB, replicative DNA helicase. This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_012918.1\|WP_015836712.1\|1649012_1649846_+\|NAD-dependent-protein-deacetylase	gnl\|CDD\|223915	COG0846, SIR2, NAD-dependent protein deacetylases, SIR2 family [Transcription].	1.02486e-36
NC_012918.1\|WP_015836724.1\|1664293_1664515_-\|NifU-family-protein	gnl\|CDD\|376458	pfam01106, NifU, NifU-like domain. This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.	7.72188e-30
NC_012918.1\|WP_015836728.1\|1667330_1668488_-\|SAM-dependent-methyltransferase	gnl\|CDD\|224481	COG1565, COG1565, Uncharacterized conserved protein [Function unknown].	3.23562e-99
NC_012918.1\|WP_015836715.1\|1652218_1653655_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NC_012918.1\|WP_015836713.1\|1649963_1650929_+\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	4.04272e-123
NC_012918.1\|WP_015836725.1\|1664709_1666110_-\|aspartate-ammonia-lyase	gnl\|CDD\|237031	PRK12273, aspA, aspartate ammonia-lyase; Provisional.	0
NC_012918.1\|WP_015836711.1\|1648520_1649003_+\|Cys-tRNA(Pro)-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	2.62714e-59
NC_012918.1\|WP_015836722.1\|1660476_1662828_-\|endonuclease-MutS2	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	6.88216e-179
NC_012918.1\|WP_015836716.1\|1653727_1654291_+\|hydrolase	gnl\|CDD\|238494	cd01012, YcaC_related, YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.	4.93772e-57
NC_012918.1\|WP_015836717.1\|1654274_1654988_-\|response-regulator	gnl\|CDD\|381099	cd17546, REC_hyHK_CKI1_RcsC-like, phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC. This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.01941e-28
NC_012918.1\|WP_015836721.1\|1659274_1660195_-\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	1.89688e-68
NC_012918.1\|WP_015836726.1\|1666136_1666601_-\|ferritin-family-protein	gnl\|CDD\|153104	cd01045, Ferritin_like_AB, Uncharacterized family of ferritin-like proteins found in archaea and bacteria. Ferritin-like domain found in archaea and bacteria (Ferritin_like_AB). This uncharacterized domain is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins whose function is unknown. This family includes unknown or hypothetical proteins which were sequenced from mostly anaerobic or microaerophilic metal-metabolizing and/or nitrogen-fixing microbes. The family includes sequences from ferric-, sulfate-, and arsenic-reducing bacteria, Geobacter, Magnetospirillum, Desulfovibrio, and Desulfitobacterium. Also included are several nitrogen-fixing endosymbiotic bacteria, Rhizobium, Mesorhizobium, and Bradyrhizobium; also phototrophic purple nonsulfur bacteria, Rhodobacter and Rhodopseudomonas, as well as, obligate thermophiles, Thermotoga, Thermoanaerobacter, and Pyrococcus. The conserved residues of a diiron center are present in this uncharacterized domain.	2.79769e-21
NC_012918.1\|WP_043578523.1\|1666701_1667334_-\|HAD-hydrolase-like-protein	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	1.05137e-19

>NC_012918.1|WP_015836719.1|1656801_1658151_-|replicative-DNA-helicase
MNAMDMRKLPPQSIEAEMSILGGILVDNEAINRVLEILVPDDMYRESHRKILRAMIDLNERGEPCDLITMTTILKKKGELEEVGGGAYLATLVDFVPMAANISYYCKIVKEKWLTRKLISAATDIVSKGFEDKIDTEELLDAAQKVIFEISENKIRPAYYQVSDILKDTIKNIELLYEKKELVTGVPTGYTDLDKLTAGFHAGDLVIIAGRPAMGKTTFALNVAQYAAIEADQSYPAAVFSLEMPKEQLVERLLCSVARVDLGRLRSGHLLENDWPKLTKAAGKLHDAKMFIDDTPSITIMELRSKARRLKAEHNIGLIVIDYLQLMRGGANPESRQQEISEISRSLKGLAKELSIPVIALSQLNRGLEQRSDKRPMMSDLRESGAIEQDADIIMFVYREEVYEKDKEDLKGKAEVIIGKHRSGPTGTVHLSFRGEFTRFENLSSRDEY
>NC_012918.1|WP_015836718.1|1655233_1656517_-|hypothetical-protein
MSRYNAMREIPATAGFKEGDVFFLCGELFGRGYANGIVDEARAKGMTIIGATVGRRDNDGTLRPLNAEELATAEENLGGKIINIPLEAGFDMEPGSDGIAPVDRFKGVKPDDWASVKLDQAEIEFSKKRGTERFCKNLAAVVAEVEKMLPAKGRLLVVHTMAGGIPRARVFMPILNKLFKGQGDRFLSSEAFWNSDMGRLCDASFNEVTADTFRYLIDATAGLREKREVTYAAYGYHGTGVLIDGVVTWQSYTPYLQGWAKIRLEDIAIEAWEKGIKATVYNCPEILTNSSALFLGVENSLYPLMASLRAEGEQKIVKECEALLKEGATVDTLLDIANTYLTSDLVTSTRDFDSWPQHNQPQQQEYMLNVSAELISLNADPKEIVCAVLSKGVFQGVGKLMFDSSWEPKAPVFWLNHDVIAKTLVKM
>NC_012918.1|WP_015836717.1|1654274_1654988_-|response-regulator
MASKVLLVDDVSMFIELERDYLQLSAVTVLTARDGEEALRICRLQRPELVFMDLHMPIMNGADCCREIKRDNRLSTAVILITTEGKEEDRQLCLQAGCDGFLTKPLDRHAFLEAARKLLPAIDRRDQRVNSRFNVKFRAFGLTLSGFASNLSQNGMYVTADVELEEDATVETIFALPEPFGAIIQTRARVAWLNSSKTRKKPSLPPGFGLEFLSISEEEREQIGRFVDSLERTSARV
>NC_012918.1|WP_015836716.1|1653727_1654291_+|hydrolase
MTLLERFFLERENAQLVVVDVQEKLCRAMDEKVLAKLTGNISILLDAAAELGIPALATEQYVKGLGETLPVLKEKLQAASLEKMTFSCCGGEGFMEALEKNGRRQVILVGMETHVCVLQTALELLSRGYVVHLVCDAAMSRRKQNWEIAIKTMTAAGVVMTSTESVLFQLLRVAGTEEFKKLSKLVR
>NC_012918.1|WP_015836715.1|1652218_1653655_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MSINNILVADDEESMRWVLSKALRKKGFNVELARDGNEALRLIKENVYDLALLDIKMPGMTGLELLDRVKEERSDLFVVIMTAEASMKNAVEAMKRGAYDYLTKPFDLGVIDAVVEKVSRAREMTSQVSLLKEELKDRYQLEKTIIGNSPAMRDVYKTIGKVAPSDVTVLVQGESGTGKELIARAIHYNSKRLGKPFIPLNCAAIPKELLESELFGFEKGAFTGATERKLGKFEQANGGTIFLDEIGDMPLDLQAKILRVLQEREITRTGGNQSIQVDVRVVAATNQDLEESVRNKQFREDLYYRLNVIPIHLVPLRDRKEDVPLLVQYFLTKICAELEVPLKRCSADAIKLLTNYSWPGNIRELENTIKRGVILSPDPLLVASDFPGLRSRQSEGKGEELSLEGIVDLKLRGCFSNMEKMESGDVHAMVLEQVERPLIRFVLEKTRGNQVRAADILGINRNTLRKKITELGIELRKE
>NC_012918.1|WP_015836714.1|1650921_1652007_+|PAS-domain-containing-protein
MSEKLESYYANVIDSVGDGVIVLDNAGAVTLVNPAAEELAGVSRRQAMGVLFSEIFKGEGPLNEMVAKTVETGMSVSDHENIVVKRGGKLIPVGASTSPLLSASGERIGTILLLRDLTNVRELESAVRQADRLSALGGLAAGLAHEIKNPLGGIKGAAQLLELEFPDNEDLREYIRVMLKEVQRVNLIVEELLALASPGRLKLSKVNLHRVLSDIVLLQKNASEGKEVYLQQYFDPSIPPILGDEALLTQLFLNLIKNALEAVEAGGVVKVTSRVLSDYSMTQRGERRARMVAIDIADNGPGIEAEVLENMFTPFFTTKSQGTGLGLAICQKIVSEHRGMIKVDSDAKRGTVFTVMLPLVQ
>NC_012918.1|WP_015836713.1|1649963_1650929_+|tRNA-dihydrouridine-synthase-DusB
MQKTVAIGPLVLKNQLFLAPMAGITNLPMRIVSREGGASFAFTEMVSVNGLTREGRKSFDLLKSCAEDRPIGMQLFGDDPEMLAEAARLVEDHGELIDINMGCPVRKVVGTGAGSALMKDPRKVGRIVRSVRAATRLPLTIKIRTGWVCGDDTFLEVGRIAQEEGCDAVTLHPRSRAQMFEGKADWSRIAELKSTLSIPVIGSGDLFSAADVAGMLAETGCDAVMVARGAMGNPWIFREALSLLAGEEPAPPSVQERLALSRRHLELFTEFAGGRVALMEMRKHLSWYSKGLPGAAHFRAAVNRIESAPELIRAMEEFFDV
>NC_012918.1|WP_015836712.1|1649012_1649846_+|NAD-dependent-protein-deacetylase
MDLSRSFEEAAELVAKAQALVVAAGAGMGVDSGLPDFRGDQGFWNAYPLYHRLGISFVDAANPEHFERDPRFGWGFYGHRTNLYRETVPHRGFQLLLDWARRYRLDCFVATSNVDGQFQKAGFAADAVLEFHGSIHHLQCTRPCSSAIWENREEFRIDTETMRADHVPLCPRCGSPARPNILMFGDYGWIGDRTQRQQERFRQFLSRQGEGRVVVVEMGAGTAIPTVRAASERIGSLAHGRVIRINPREPRIKAPHLSLPCGALEGLKGIEEVLSRS
>NC_012918.1|WP_015836711.1|1648520_1649003_+|Cys-tRNA(Pro)-deacylase
MAKFKSPVTAAVRVLRQAGVSYGEHPYQYEEKGGTAVSARELGVDERCVIKTLIMEDEAKSPLVVLMHGDLQVSTKELARAIGVKSVAPCTPETANRHSGYMVGGTSPFGTRKQMPVYLEESILELPLIYINGGSRGFLVSMPPKELVRVLQPVLVQVGI
>NC_012918.1|WP_015836710.1|1647978_1648392_-|response-regulator
MQNDNGQVVAKVLVMDDDEMVRFVAGETLKRYGFEVEFAIDGSEAVELYRERHQAGRTFAAVILDLNIPGGMGGQEAMKRLLEIDPGAKGYVSSGRTDDPVMVNFKTFGFAGTIEKPYFYLNKQLMEEFSKSLHENG
>NC_012918.1|WP_015836720.1|1658569_1659223_-|DNA-repair-protein-RecO
MYLRPMRKAEVEAIVLRLTDFGEADRIVTFFTLEQGKLQGVARGAKRSKKRFAGALEAFAHLKLQLHLGNSLPTLSSADIVSIFPGIRSDLVKIGSAAYACELVERLTPDEEPAPRLFRLLYCYLERLDQDPPSASDRRFFAVNLLKILGYQPDLKVRGISEETARLLALAMQTGRFGAVFFPEPLLKEADLLLNPAIDLHLDRELRSLAFLKEVGG
>NC_012918.1|WP_015836721.1|1659274_1660195_-|dihydrofolate-reductase
MIISTIAAMSDNRVIGAGGKIPWDIPSDLTRFRSITIGHAVIMGRKTYDSIGHPLLGRRNIVLTRKGSKIEGCEIAGNLHAAIAAAEGEEEVFICGGSEVFQEALPFCQRIYLTIVHGNYQGDAFFPELPDGFVELHREEFPDTTPPSSFVVLEKVERVDAGADARQLRRKGREALNRQLYFLARRCFEQAQALDENPETASDLAYSLIKSGAQGREARDMAERALQQQPQNVCILLNAGRVLILSGEKSKGLDMLRRGVQSGGGPEFLAELARCGNRKIQPIKSLPRSHPLNRYLGLLLSRMNLK
>NC_012918.1|WP_015836722.1|1660476_1662828_-|endonuclease-MutS2
MISTDTLKRLEFDKILDTVASYAHCDASHLGALSITPLSARDEIELRLGLVEEVRKLTRFGIALKLSEFEDITPQVRAVRPTGSVISPLELQRFIPTLRVMGAISAQLGFRTDVPLLTSQAGSITGFPDLLNPLEHTVNEEGEILDTASRLLADIRGRKKGLTARIKKRLEEIVRERHTAIFLQDDFITQRSGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVADERAEEIRIVRQICNWIREDAEQILEQFEALVRMDILNCIATLSDKLRSETPVISPSPAILLKSARHPILTLMGKEVVPLDLELAADNRVMVVTGPNTGGKTIAIKSAGLLCVMALCGMPVPALPGTVLPLVESILVDIGDEQSIEESLSTFSAHISKISNIIEQAGQGALVLLDELGTGTEPGQGAAIACAVLKELQEKGALVVATTHLTEIIGFVQREEGMMNAAMAFDRDRLAPLYRLVVGEPGESHALEIASRYGLPDRVVRFARGMIGTMEADFHALLRDLKDKRAQLERALEDMAEREEKVSFAERNLVDRRDEAAQLVKDAKEKGLLEAQQIIWKAKREVAALLEEAKREKTKTREAKEKLDQAASELEQALEELHPEENVDPEKVAAGDVLFVKPLNCDATVLAIDTRSGKARVRAGSMEMEVQVNSLLKPKGREPKKVQKRREKQQAQEQERAEPASTINLLGMRVEEAVGVLEPFLNHAALDRIQEVHIVHGKGTGALMKGVRSYLADHPLVASFRTGERYEGGDGVTVVTLR
>NC_012918.1|WP_015836723.1|1663005_1664193_-|cardiolipin-synthase-B
MTSIRRKRKQLLFQTKKFFDFFRRNTEAVSFAGNRATLYRYGSDFFPALFDAIPKATTSICLEFYTVADDETGRLMADALLAAAARGVRVYLLYDYIGCFDTPAAFFKRLSKGGVCCRAFNPPPFRKGLAWFDKRDHRKLAVIDGWCVFTGGMNIANVYSGLGKKRTKWRDVGLRIEGEVGLELLRLFQETWTGECGAPPIGCDPGPPPDIVGDANVMVINGGPHHKRSFIRSAFRLAIAGASESVTIASPYFVPGPRVIRSLLRAAGRGVRVRLLLPHKSDVPLVRLVSRTYYAQLLKNGIEICEMNSAVLHAKVLLIDGNWTMVGSANMDLRSFHRNYELNVVVDSQIFGAQVEQMLEFDLAGARRIVLHEHERRGWSVRFLERLFSPVSWFL
>NC_012918.1|WP_015836724.1|1664293_1664515_-|NifU-family-protein
MTEEVKAILEQIRPALQADGGDVELVEVTDDGIVKVRLVGACGHCPMSTMTLKMGIERTIKDKIPGIKEVVAV
>NC_012918.1|WP_015836725.1|1664709_1666110_-|aspartate-ammonia-lyase
MATRLEKDTMGVVEVPEGAYYGAQTQRAVANFPISGLKPHHALVRSTVRIKKCAAQANMGTGRLDAEVGGAIVKAADEVLAGKFADQFVVDPFQAGAGTSHNMNVNEVLANRAAELLGGKQGDYSRVNPNDHVNMAQSTNDVFPTAMRLAALELAEQTMTELFGLAQALEQKGKEFDGILKSGRTHLQDAVPIRLGQEFAAYGKAMADNRAGIERALPALRELGIGGTAVGTGLNAEEAFIDLIVLGLSRETGQKLNRGGNLVERMQNMDPFVALSSALKGTAINLIRIANDLRLLASGPRTGLGEINLPAMQPGSSIMPGKVNPVMPEVTTMVCFQVVGADLTVAMAAQAGQLELNVMMPVIAFNTLFSLEILKNVVHQFSTLCVAGISANEERCRNYLDQSVGLATVLAPSIGYAAAAEVAKESARTGKSIRGVILERGILTEAELDQVLAPFPLTTPGVHGKE
>NC_012918.1|WP_015836726.1|1666136_1666601_-|ferritin-family-protein
MSDAGNSVLDALMLGMEMEKDTFDFYVKAAQKTFNPEGKRIFRWLAESEETHYLKLAEIYKSLDAGGGWVFYAASTIELEPSDGEPGVGFETDDIEALRLAREIEEKGIDYFEDLLEKTTDPDGRRMVETLRREEEEHLRVITEKLHFLEGRFS
>NC_012918.1|WP_043578523.1|1666701_1667334_-|HAD-hydrolase-like-protein
MTSPLPRPESLKAIVFDLDGTLYRDDRLGEEVNQSAIRYVAALRLVDMADAEAMLQRARVESGDGGTLSRAVVALGGNLPEMHRRFAQEIHPDQFLKRDERVPQLLKLLATRFQLYLYTNNNRDLSGRIMAQLGVTGLFRKIFTIEDYWLPKPDPKLINDILTKIAVKPAEALFVGDRYEVDLLVPASIGCPIFESKTVEELLTLEQLVH
>NC_012918.1|WP_015836728.1|1667330_1668488_-|SAM-dependent-methyltransferase
MADGATTKLAEIILNRIRTSGDITFASFMDAALYEPDLGYYTSAGRKVGAEGDFYTSMNVHSAFGRLIAQEICRFWEVLDSPASFTIAEAGAGGGQLAQDILDAISEDNPAFYSGLTYRLIEKEPSLQQAQAARLSRHADRLAWSSPDELAAGTLSFTGCIISNELFDAMPVHIVELTEAGLREVYVSADDNGFVERLLPPSTPELEQYLRKYEVRLLPGQRAEINLAASGWIAQAAATLTRGFVLTIDYGYLSGELYTPQRKNGTLLCYYKHSTNENPYQLVGEQDITTHINFSQLIVDGEESGLKKAWYGEQYRFLLAAGLMEELIRLEAQAKDEQESLKHRLALKKLMLPEGGMGDTFKVLIQSKGVDNPQLLCMRKWGMGL
>NC_012918.1|WP_157506124.1|1668933_1669341_+|hypothetical-protein
MIVALVISMGWAAFMTWMTIKAQNPEKIPEIQEAIKNIFFRIFVWMSNLFACGILIREYLSSAPISRRDVFTIVWSTSLIVLFLILRIAKALLEQSKVNLKHMELHQKIANNEGQIIKVIEELKKRTHNQEDTPA

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Crispr_ID: NC_012918_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012918_6

2235181-2235280

Orphan

Consensus_repeat	Method
GCATCTTGACGGCACCGTTGGTTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012918_6

>merge|NC_012918|6|2235181-2235280|CRISPRCasFinder
GCATCTTGACGGCACCGTTGGTTATCGCTGAACGGCTGTTTCAACGTTTGACTATCGGTTCACTTAAAGGGGGGCCGCCTCTTGACGGCACCGTTGGTTA

>NC_012918|6|6|2235181-2235280|CRISPRCasFinder
GCATCTTGACGGCACCGTTGGTTA	TCGCTGAACGGCTGTTTCAACGTTTGACTATCGGTTCACTTAAAGGGGGGCC
GCCTCTTGACGGCACCGTTGGTTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012918.1\|WP_015837227.1\|2240558_2240942_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837224.1\|2236219_2236798_+\|SMC-Scp-complex-subunit-ScpB	unknown	unknown	gnl\|CDD\|377219
NC_012918.1\|WP_015837222.1\|2234136_2235120_+\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|234866
NC_012918.1\|WP_015837225.1\|2236862_2237663_+\|AmmeMemoRadiSam-system-protein-B	unknown	unknown	gnl\|CDD\|275135
NC_012918.1\|WP_015837215.1\|2225637_2226021_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|107120
NC_012918.1\|WP_015837223.1\|2235372_2236230_+\|chromosome-segregation-protein-ScpA	unknown	unknown	gnl\|CDD\|234635
NC_012918.1\|WP_015837228.1\|2241219_2242260_+\|DHH-family-phosphoesterase	unknown	unknown	gnl\|CDD\|223691
NC_012918.1\|WP_015837218.1\|2227960_2229226_+\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|223497
NC_012918.1\|WP_015837213.1\|2223131_2224928_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	unknown	unknown	gnl\|CDD\|273520
NC_012918.1\|WP_015837214.1\|2225121_2225598_+\|DUF1456-family-protein	unknown	unknown	gnl\|CDD\|227144
NC_012918.1\|WP_015837221.1\|2233412_2234093_+\|site-2-protease-family-protein	unknown	unknown	gnl\|CDD\|100079
NC_012918.1\|WP_015837220.1\|2232193_2233090_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NC_012918.1\|WP_015837216.1\|2226030_2226726_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837226.1\|2237662_2240290_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223690
NC_012918.1\|WP_015837230.1\|2243604_2244927_+\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224787
NC_012918.1\|WP_015837231.1\|2245004_2246033_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl\|CDD\|236585
NC_012918.1\|WP_015837217.1\|2226913_2227708_+\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223489
NC_012918.1\|WP_015837219.1\|2229216_2232180_+\|SMC-family-ATPase	unknown	unknown	gnl\|CDD\|223496
NC_012918.1\|WP_015837229.1\|2242314_2243457_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|131032
NC_012918.1\|WP_015837232.1\|2246032_2246860_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708

Protein	Function_ID	Function_description	E-value
NC_012918.1\|WP_015837224.1\|2236219_2236798_+\|SMC-Scp-complex-subunit-ScpB	gnl\|CDD\|377219	pfam04079, SMC_ScpB, Segregation and condensation complex subunit ScpB. This is a family of prokaryotic proteins that form one of the subunits, ScpB, of the segregation and condensation complex, condensin, that plays a key role in the maintenance of the chromosome. In prokaryotes the complex consists of three proteins, SMC, ScpA (kleisin) and ScpB. ScpB dimerizes and binds to ScpA. As originally predicted, ScpB is structurally a winged-helix at both its N- and C-terminal halves. IN Bacillus subtilis,one Smc dimer is bridged by a single ScpAB to generate asymmetric tripartite rings analogous to eukaryotic SMC complex ring-shaped assemblies.	1.33635e-66
NC_012918.1\|WP_015837222.1\|2234136_2235120_+\|tryptophan--tRNA-ligase	gnl\|CDD\|234866	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed.	3.07419e-174
NC_012918.1\|WP_015837225.1\|2236862_2237663_+\|AmmeMemoRadiSam-system-protein-B	gnl\|CDD\|275135	TIGR04336, hypothetical_protein, AmmeMemoRadiSam system protein B. Members of this protein family belong to the same domain family as the mammalian protein Memo (Mediator of ErbB2-driven cell MOtility). Members of the present family occur as part of a three gene system with an uncharacterized radical SAM enzyme and a homolog of the mammalian protein AMMECR1, a mammalian protein named for AMME - Alport syndrome, Mental Retardation, Midface hypoplasia, and Elliptocytosis. Memo in humans has protein-protein interaction activity with binding of phosphorylated Try, but members of this family may be active as enzymes, as suggested by homology to a class of nonheme iron dioxygenases.	2.50994e-121
NC_012918.1\|WP_015837215.1\|2225637_2226021_+\|hypothetical-protein	gnl\|CDD\|107120	PHA02100, PHA02100, hypothetical protein.	0.00101892
NC_012918.1\|WP_015837223.1\|2235372_2236230_+\|chromosome-segregation-protein-ScpA	gnl\|CDD\|234635	PRK00104, scpA, segregation and condensation protein A; Reviewed.	4.43338e-70
NC_012918.1\|WP_015837228.1\|2241219_2242260_+\|DHH-family-phosphoesterase	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	2.16636e-43
NC_012918.1\|WP_015837218.1\|2227960_2229226_+\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	2.53639e-43
NC_012918.1\|WP_015837213.1\|2223131_2224928_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_012918.1\|WP_015837214.1\|2225121_2225598_+\|DUF1456-family-protein	gnl\|CDD\|227144	COG4807, COG4807, Uncharacterized protein conserved in bacteria [Function unknown].	2.66165e-56
NC_012918.1\|WP_015837221.1\|2233412_2234093_+\|site-2-protease-family-protein	gnl\|CDD\|100079	cd06158, S2P-M50_like_1, Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with a minimal core protein and no PDZ domains.	1.13112e-62
NC_012918.1\|WP_015837220.1\|2232193_2233090_+\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	5.47492e-15
NC_012918.1\|WP_015837231.1\|2245004_2246033_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl\|CDD\|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	0
NC_012918.1\|WP_015837226.1\|2237662_2240290_+\|CBS-domain-containing-protein	gnl\|CDD\|223690	COG0617, PcnB, tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis].	8.29911e-48
NC_012918.1\|WP_015837230.1\|2243604_2244927_+\|PhoH-family-protein	gnl\|CDD\|224787	COG1875, COG1875, NYN ribonuclease and ATPase of PhoH family domains [General function prediction only].	0
NC_012918.1\|WP_015837217.1\|2226913_2227708_+\|dienelactone-hydrolase-family-protein	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	2.06409e-56
NC_012918.1\|WP_015837219.1\|2229216_2232180_+\|SMC-family-ATPase	gnl\|CDD\|223496	COG0419, SbcC, ATPase involved in DNA repair [DNA replication, recombination, and repair].	2.10442e-35
NC_012918.1\|WP_015837229.1\|2242314_2243457_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|131032	TIGR01977, am_tr_V_EF2568, cysteine desulfurase family protein. This model describes a subfamily of probable pyridoxal phosphate-dependent enzymes in the aminotransferase class V family. Related families contain members active as cysteine desulfurases, selenocysteine lyases, or both. The members of this family form a distinct clade and all are shorter at the N-terminus. The function of this subfamily is unknown. [Unknown function, Enzymes of unknown specificity].	2.36401e-167
NC_012918.1\|WP_015837232.1\|2246032_2246860_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	1.68803e-120

>NC_012918.1|WP_015837222.1|2234136_2235120_+|tryptophan--tRNA-ligase
MSNNRIVSGMRPTGKLHLGHYHGVLSNWLELQRNFECFFFAADWHSLTTEYANTDGIKDSINEMVLDWLAFGIDPEQSVIFEQSRVPQHAELNLILGMITPVSWLERNPTYKEMQENLSTKDLSTFGFLGYPVLMASDIIVYKASRVPVGQDQIPHLEITREIARRFNYLYGEVFPEPAALLTETPKVLGTDGRKMSKSYGNAIFLSDDAEETRKKVMSYVTDTQRPFKKDPGEPDRCVAYTLHSLYVDEAKREEIVVGCRSAQLGCVDCKKILAQAMVDTLAPLRARRVELAEKPGLVSEVLAEGSRKAEVVARQTMEEARAALRV
>NC_012918.1|WP_015837221.1|2233412_2234093_+|site-2-protease-family-protein
MEQFFLKLSIMLVPALMAITCHEVSHGYIADRRGDNTARYLGRLTLNPLKHLDLFGTLMIFIIGIGWAKPVPVNFNNLRRPKTDMIWVAAAGPITNFLLATLSAFAMRALIGATQGLPEGSALAVFVDPITLMLAFSVYINLLLGIFNLIPVPPLDGGRVAVGLLPLGPSTALARLEPFGMIIIIVLVFFTNAFSYVISPALSFGVHLLAGPHSNLVFGVTRLMLK
>NC_012918.1|WP_015837220.1|2232193_2233090_+|DMT-family-transporter
MPPKHRGAWLIAASAAGFATLGILIKSAFSGGANITTVLAGRFLVASFFLFIYLKVRKTPLAIGRRSSLHLLLMGMIGYGGMSMLYANAINYLPASLTGMLLYTYPALVTVIALVLREESFNAAKGVALVVCSAGLVLLLGASFEGARLEGVLSVLGAAGIYSCYIIIGNRILKNIDPLVTSLWVCASAGFTFLLYGVATGGLTLDLAPAGWLSILGIALFPTLIAVVAMFAGLRQVGATNASIISMLEPLITVLLSALLLGERITALQGFGGAVLLFGGLILQLWGQEARHETLTEV
>NC_012918.1|WP_015837219.1|2229216_2232180_+|SMC-family-ATPase
MRIISVHLKNIKSHRDKEIAFSPGINVLSGANGSGKSTIFEAIGYALFGVSAQDFVSKADRFLTIGAKKGEISVVFEPAPGELYRVTRTVGGAGKWLLAKDNGGGFEIEEHANIQETEQRIASLLGLATGRPLAEQFKLVIGPFQNDFLGPFVIKQPTKRQDAFDEILGIDTWRKTFDGTKTLASAIVAKTETIQAEVAAKMEQVSVLPAKEQELRDLREQALAKEAQLRQKLAEQEQVNQLFAGMEARKERIDSVGREVQALEERSISGKEYISTQLLLVEQSKAAAALVAEAAQGKQAYDAAETKLRRLRDQEQQKLALERKLGESDKEQAGLQSALAIENRELAETRTAMDGEKERLAQEKDALSNALLALKKSEAAAGEALALVNRSAAQFRELPVHRIEQALPYLFVALDRMAAIDEQSTERKKLVAAGATLKAEASELAARQALLDKVQAERSELAGRRLSLVEGEEKLGAGDCPFFHEPCRNLASGDASGVFEARIERIDAEISRLDRQAVELAAQVAAAQAAARELAGLEQVASELEKAGRERRKLEQDFINGFSEIAPAVLVPSLGTWLDSAELGIDLAAELPALQVELAAEPQQRKAALSEASDAWRRVVVLIEEGLDARLKEAQEPVQECALKLAQLAEKGESLAAKERELAASAEKLAFRERAIADHGKRLAALLEAVCAVKTDLAAHAGLDQAIKEAGEELVRFQADRDRYIANEKAAQELDKRQETLAKYQAKLKEIEGALTAKREELRQSVEGYDQARHEAVKQQQVELVSAVATLASEIGAVGEGVTRLEGETAALKCIAGEIEKKLAAVEALKEQGVLVKFLRNQVFKNVSSQLSERFREEISFRADRIYRSICASDEELVWGENYQVVLKDMAEGQVRERSDDQLSGGQMMSAVVALRLALLQTIGARIAFFDEPTSNLDAERRENLARAFRAIDVGQEEVTEHWYDQLFLVSHDVSFTEITDQTIQLD
>NC_012918.1|WP_015837218.1|2227960_2229226_+|exonuclease-SbcCD-subunit-D
MPVRFIHTSDIHLGKTYRCLGGDAERYQDFFTTFAAIIADAVEERVDFVLIGGDLFHTGQILPKTFAKTIEILQPLKDAGIPCLAVEGNHDWIHRRDSVSWMEALSQLGYIRLLRPSRTGDGDYLFAPFDLEQGAGGHLEIGGVNIYGLGYIGSQAANHVARICEAVDTRRNILLFHVGVWSYSPVEIGNIRPEEALPLSECFDYVALGHGHKPYVVSTPDGRPYAFNPGSPDCVNFGEERYDKGYYLVSLEEGGETLHEFRRCSPRPMLVLTVNLEGAKNADEALQRFASGVAEKLGGSSDPRSPLIEVRLCGKVGFHPFELSRDRLRLALFEVCQPLHLEIKNHLSQVSGGGGEEKVKKSLAEIERDVLAELVGANSQYQGREEELVRLSLALRDLVLKGEVEGEELLALLPSGGAECA
>NC_012918.1|WP_015837217.1|2226913_2227708_+|dienelactone-hydrolase-family-protein
MKQYLFALMIGMVAQNAFAGVVGKTVEYRQGDTVLEGYVAYDDSVKGKRPGVLVIHEWTGLGAYEKGRADQLAKLGYVAFAADIYGKGVRPATQEQAAKEAAKYRGNDRTLIRARSAAGLEALSKLPQVDPKRLAAIGYCFGGTAALELARSGAAVLGTVSFHGGLSTPVAADAKNIKGKVLALHGADDPYVKPPEVDAFQQEMRQAKVDWQMNYYGGAVHSFTNPKSGNDPKKGAAYNEKADRRSWEAMKIFFTEIFGQKQKH
>NC_012918.1|WP_015837216.1|2226030_2226726_-|hypothetical-protein
MRQPSPIHLILVVGCVFSSLCLAGCAGGRITFHANNSASLQTVEADLQYARLQAESTREALEEMVFADPPDLGRAYRDFDEKATRMNLVGERLVRHADGMEYQGSSYLVEPEKSATECRYPRLSDTARTKPLELGGAFDPIAAAAISVRRAYRAFESDLSNIRSILSIHQTTKRIEIVDIFIKKAAVDEESLNEALGHAQALVQEAKTASPDPSLAPNGQGEKSVALPEGG
>NC_012918.1|WP_015837215.1|2225637_2226021_+|hypothetical-protein
MDKGKQQESGSEMAEAPVDAVEAEIDPAVISAGLSKVRRRRWVVWSVMIVYLPTMWTTQKITHSFSGSMPVFFIWFLLLLVAMGFSAVVRCPRCGNYYHVHGMILLYLRRCLHCQLPLNQDKGPPRF
>NC_012918.1|WP_015837214.1|2225121_2225598_+|DUF1456-family-protein
MTNNDVFRRLRYAMNMNTQTVVETFRLSGMKMGQADITSLVKKEDEEGYKECSDEVLEAFLDGFIALKRGKREGEPEARKDEVQLTNNDILKKIRIALALKEDEMLMLFKLAHFPVSKSELSAVFRAKGQENYKPCGDQMLRNFLKGLTVKYRETPAK
>NC_012918.1|WP_015837213.1|2223131_2224928_+|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein
MTSTSKKKLLIIVAALSIVAGSCYGIYAWKNSHSDEGKQISYTAFMEKVNAGGIAKVKIAGDQIDAVGKSGEKFRLFLPAGAELADALVAKKIDFSSNPAASEPKWFEISIILLVALFLVMVLKRYGGVGRSKARIIDCSESLTRFNDVAGAEEAKAELLDTVEFLKDPAKFSALGGKMPTGVLLVGPPGTGKTLLARAVAGEADVPFFSISGSEFVEMYVGVGASRVRDLFAQAKKAAPCIVFIDEIDAVGRKRDAAVGGGASDERDQTLNQLLVEMDGFAVNSGIVVLAATNRPEILDAALLRSGRFDREVTVGAPDIRGREAILKVHSKNVPLSPEVDLMVIARGTPGMSGADLANVVNEAAILAARSNKGCVEMLDFDNAKDKVLMGAEKKSMVLSDKSKLSTAYHEAGHVLVAKLVPGCDPVHKVSIIPRGRAMGVTLQIPEEDIYCYTKEMLLAHLKVLMGGRAAEEIIFHTTTTGAGNDLARATDTARKMVSEWGMSRAFGPVAFGHQENTDGGGKKGFSDATALEMDNEIRSIVTTCYADVRTLLEENLDVLERLTQELVVKETLDAAEIDAILGLATADDAEASCCAAA
>NC_012918.1|WP_015837223.1|2235372_2236230_+|chromosome-segregation-protein-ScpA
MSLDTMQSNLFSDALEQSYRVQIEEFEGPLDLLLHLIKKNELDIYNIPIAAITRQYLEYMELMKELNLDIAGEFLVMAATLLQIKSRMLLPATQEEDGEAEVEDPRAELVRRLLEYQRYRDASQLLSARNLLGRDVFARSFDSPELAAMEPQEEPADVELFELIEAFQRVLARVSVDTFHDVVADGISIADRIGEVLSVLHAEKTVCFDALFTVGMTRDLLVVTFLSILELAKMKLIRVTQVESLGSIWLTLSADQQEAGPEQQGGEQEVGDLNSLETAEDAVVG
>NC_012918.1|WP_015837224.1|2236219_2236798_+|SMC-Scp-complex-subunit-ScpB
MSGKPLKSIVESLLFVYDQPLSLDRLALILEEFERSDLRAALDELMEEYANAERGIVLSHVGGGYQLRSRPEHADYIRRLTKAKGVKFSQSALETLAIIAYRQPITRAEVEYLRGVDSGGVMKSLLEKKLLRILGKKDVPGKPLIYGTSREFLELFGLKDLNALPTLKEIQELVPPDPFADQPALPLGSVEG
>NC_012918.1|WP_015837225.1|2236862_2237663_+|AmmeMemoRadiSam-system-protein-B
MIRQPAVAGKFYSADPEQLREELSRMIPREEPAKAIGVVAPHAGYVYSGGAAGKVYAAVEVPDAVIVLGPNHTGMGAAAALAPSGEWLTPLGPVRVNDRLSQLIMKHAPLVREDSVAHRFEHSLEVQVPFLQYRNPQVSIAALCLSLPDFDSISRVGTGIAHAIAEYGSEVLIVASSDMTHYESAAQAKAKDDLALERMACMDPEGLLRVCRDKDISMCGVIPATAMLVAAKTLGASGSRLICYTNSGEVNGDLNAVVAYAGLTVS
>NC_012918.1|WP_015837226.1|2237662_2240290_+|CBS-domain-containing-protein
MDVITTHLNADFDCIGSMVAAKKLYPEALLVFSGAQEKSVRDFFQKGHPQDLEFARIKEIDFSAITRLIVVDCQHSSRIGKFGELAKSGSVELHIYDHHPTSSGDMEPTGGVIRPCGSTTTILAGMLIERGVEITPFEATVMMLGIHEDTGNLTFPSSTAEDYTVAAWLLERGAYLNEVADSIGRELTVEQVSLLNDLLVSLKTTTLKGVDVSIAHASVDRYIGDIATLAHMIRDMENLQALFLVVGMEDRVFVIARSRVPEVRVGEILQELGGGGHATAASATVRGLTLIQVLERLDAVLRRRVDPRRVARDIMSSPVKTISPDCSIEEARERLVRYNVSAMPVISEEGVLGIISRKTVEKALYHNLNQVPVSDYMHSEFHVASPDTPITEIQSYMVGGDARLVPVISEQGLIGVITRTDLLRYSLGGEALYDLSRDALQVKNREVEALMNKHLPQRTTVILHDLGRIGDQLDLTVYAVGGFVRDLLLDIQNMDIDVTVDGDGILFAETFAAQFGCRVKSHQKFGTAVIVFPDGFKIDVASTRLEYYVSPGALPTVERSSLKMDLYRRDFTVNTLAIALNGDSFGKLIDYFGAYRDLQSRVIRVLHNLSFVEDPTRVFRAIRFEQRLNFKIAKHTEDLIKNAVKMEFLEKLGGRRLLAELVQILREKEPLKGIGRMASLGLLRFIHPVIELTPAMQGALEETRYVVSWFDLLYLERPYESWSVYFLTLCEGLTEEQFWGTCTRLAVAEHYKERLVEMRRQSEELIGNLERKLARSEKVDNSEIYFTLKGLGVEVLLYHMAKSRSAEVKRCISLYFTKLDGMHPLIGGEDLKELGVEPGPLYRELLDLVLSARLNGKSASREDEIRLVREVLEGV
>NC_012918.1|WP_015837227.1|2240558_2240942_+|hypothetical-protein
MNKLKRCIAIVVTLVFMATPCLAAENAFKTVFEHSMYGGLAGGLVGAALLVFTNKPADHLDYIAYGAAGGVLVGAAYGVATTSRSLAEIENGKVKFAIPTIKPEFREGNVKGQTTLVAVAELIRGKF
>NC_012918.1|WP_015837228.1|2241219_2242260_+|DHH-family-phosphoesterase
METSTKPPDLLAYTDSLLTWVSGRGRILIVVHDNPDPDSLASAMALRHFFAVKLNREAVIAFSGMIGRSENLAMAKLLQIPLTPLPLIDLKSFQVVCLLDTQPGTGNNSLPAGTRTDIVIDHHPMREFSAACRWVDIRPDYGTTATILYEYLKVQGVSIGTKMATALFYAIKSETQDLGREARRADRDAYLDLFPLANKTLLNSITRPSLPREYFISLHSALEHAALYGNVLVASLKGIQFPEVVAELADLLVRLEGTETVLCLGHYSAELVLSIRTSNEEINAGELIRKLVAGIGSAGGHGMMAGGKIDLSDNSEEAIRELENLLTERLLAEMKISDPKPVPLVP
>NC_012918.1|WP_015837229.1|2242314_2243457_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MPVFLDNAATSFPKPETVYQAMDAALREVGVAPGRGGYRQSLAAARIVYEARSALARFFGVSDSSRLIFTHSATESINIAVNGLLKPGDHVVSTRVEHNALLRPLHLAASRGVEVSYVPSDRFGVVSEREIERAMRPGTRLVALAHCSNVTGAVQPIEAIARVARRNGALFLVDAAQSAGFFPIDVELTGIDLLAAPGHKGLYGPPGTGVLTIAEGLNLEPLLVGGTGGSASSPEQPDQLPERLESGTINTPAIAGLKAGVEFVLSTGIEVIRAKEEQLVNRLLAGLRATPGVEVYGPPEGERGAAVSFNAAGHDPAAVSFLLDSDYDISVRAGVHCAPDTHRSIGTYPTGTVRVSPGFFNTEADIDFFLKALREITARR
>NC_012918.1|WP_015837230.1|2243604_2244927_+|PhoH-family-protein
MKKIYVLDTNVLLYDPQALTKFEDNSIVVPITVIEEIDRFKKDMNETGRNARQVSRLMDAFRKEGSLSQGLALESGGTLKIEIYEEKVMKRLPPELREERGDNRILAVAVDLMESQSEMPVILVTKDTNLRIKADALGLDAQDYESDKVAIDDLFDGFVSLEVGAEVVDRFYSQGWLDTELELQPNEYVLLAEAGNPSHSAIGRFDRVSHRIGPLGKLDKEGVWSLFPRNLEQSFALDALLDDNIKIVTLVGKAGTGKTLLAIAAGLQKTAEENVYNRLLVSRPVFPMGRDLGFLPGDIEEKLTPWMQPIFDNVELLLSGHEGEKRQHNKGYKELMAMGILEIEPLTYIRGRSIPNQYMIVDEAQNLTPHEIKTIVTRAGEGTKIVLTGDPYQIDNPYVDAESNGLTYVVERLKEQAISGHITMTKGERSELAELAANLL
>NC_012918.1|WP_015837231.1|2245004_2246033_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MLVLALESSCDETAAAVVKDGRTVLSSIVASQISVHAEYGGVVPEIASRKHLESVSFVVEQALAEAGVGLDRIDGIAVTQGPGLAGALLVGISVAKGLAFGRSLPLVGVNHIEGHLLAVFLEAPVQFPFIALAVSGGHSHLYRVDGIGRYQTLGQTVDDAAGEAFDKVAKLIGLPYPGGVAIDRLAVSGDPKAIKFPRPLLHDGTFNFSFSGLKTAVLTHVGKHPEAKEAGINDLAASFQAAVCEVLTKKTAAAVAATGIKRLVVAGGVACNSALRRSMAEYAAANGVELSIPSPALCADNAAMIAVPGDYYLGLGVTSGFDLDALPVWPLDKLALRLKEHC
>NC_012918.1|WP_015837232.1|2246032_2246860_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MEKIRAKKEFGQNFLVDDSVLTRIVACVAPTADDCILEVGPGRGALSRLLAESGARFLAVEWDRELLPLLKAEFATAQNVEIGHGDILRVDLPLLLGSRVEGKKWKVAANLPYNISSQVLFRFMEHSELFEKLVLMLQKEVGDRLTAPPACKEYGALTVLLRLHFDIRREFIVKPGSFRPVPKVDSAVLSFLPLPGPRVEVGDEELFRRVVKGAFLQRRKTLLNSLRSSGFDDADGFLSAALSRSGIDGGRRGETLSLEEFARLTRELLAGKTLA

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Crispr_ID: NC_012918_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012918_7

2379811-2379986

Orphan

Consensus_repeat	Method
CTCTGGGAGAGGGTCGGGGTGAGGGAAGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_012918_7

>merge|NC_012918|7|2379811-2379986|CRISPRCasFinder
CAGAGGGAGAGGGGAGGAGTGAGGGAAGAATTTCAACCAGCTACTTATTTCACGAACTCATCCAACTCCCCCTCGCCCTCTGGGAGAGGGTCGGGGTGAGGGAAGCCTTTGAAAGTACCCAATCCTTAACTCCAATACCCCTTCTCACTCTGGGAGAGGGTCGGGGTGAGGGAAGC

>NC_012918|7|7|2379811-2379986|CRISPRCasFinder
CAGAGGGAGAGGGGAGGAGTGAGGGAAGA	ATTTCAACCAGCTACTTATTTCACGAACTCATCCAACTCCCCCTCGCC
CTCTGGGAGAGGGTCGGGGTGAGGGAAGC	CTTTGAAAGTACCCAATCCTTAACTCCAATACCCCTTCTCA
CTCTGGGAGAGGGTCGGGGTGAGGGAAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012918.1\|WP_015837346.1\|2380012_2381173_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226957
NC_012918.1\|WP_015837343.1\|2376442_2376733_+\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376835
NC_012918.1\|WP_015837352.1\|2389351_2390218_+\|GerMN-domain-containing-protein	unknown	unknown	gnl\|CDD\|378464
NC_012918.1\|WP_015837340.1\|2371542_2371701_+\|rubredoxin	unknown	unknown	gnl\|CDD\|238372
NC_012918.1\|WP_015837347.1\|2381185_2381854_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_012918.1\|WP_015837341.1\|2371781_2373116_+\|NADH-oxidase	unknown	unknown	gnl\|CDD\|163244
NC_012918.1\|WP_015837353.1\|2390312_2391551_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|236674
NC_012918.1\|WP_015837338.1\|2369405_2369786_-\|lactoylglutathione-lyase	unknown	unknown	gnl\|CDD\|319940
NC_012918.1\|WP_015837355.1\|2393308_2393851_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837350.1\|2385080_2388218_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226220
NC_012918.1\|WP_015837337.1\|2368997_2369369_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|334450
NC_012918.1\|WP_015837339.1\|2369852_2371049_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NC_012918.1\|WP_015837344.1\|2376750_2379264_+\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NC_012918.1\|WP_015837345.1\|2379268_2379490_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837354.1\|2391547_2392897_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_012918.1\|WP_043578626.1\|2368549_2368882_+\|cytochrome-c	unknown	unknown	gnl\|CDD\|184253
NC_012918.1\|WP_015837351.1\|2388364_2388826_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837349.1\|2383445_2384843_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|379862
NC_012918.1\|WP_015837342.1\|2373323_2376128_+\|aconitate-hydratase-AcnA	unknown	unknown	gnl\|CDD\|236445
NC_012918.1\|WP_015837348.1\|2382149_2383421_+\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455

Protein	Function_ID	Function_description	E-value
NC_012918.1\|WP_015837346.1\|2380012_2381173_+\|ABC-transporter-permease	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	4.86769e-30
NC_012918.1\|WP_015837343.1\|2376442_2376733_+\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|376835	pfam02583, Trns_repr_metal, Metal-sensitive transcriptional repressor. This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression.	1.15472e-26
NC_012918.1\|WP_015837352.1\|2389351_2390218_+\|GerMN-domain-containing-protein	gnl\|CDD\|378464	pfam10646, Germane, Sporulation and spore germination. The GerMN domain is a region of approximately 100 residues that is found, duplicated, in the Bacillus GerM protein and is implicated in both sporulation and spore germination. The domain is found in a number of different bacterial species both alone and in association with other domains such as Amidase_3 pfam01520, Gmad1 and Gmad2. It is predicted to have a novel alpha-beta fold.	2.78135e-11
NC_012918.1\|WP_015837340.1\|2371542_2371701_+\|rubredoxin	gnl\|CDD\|238372	cd00730, rubredoxin, Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are believed to be involved in electron transfer.	4.3835e-23
NC_012918.1\|WP_015837347.1\|2381185_2381854_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	3.72472e-113
NC_012918.1\|WP_015837341.1\|2371781_2373116_+\|NADH-oxidase	gnl\|CDD\|163244	TIGR03385, Coenzyme_A_disulfide_reductase, CoA-disulfide reductase. Members of this protein family are CoA-disulfide reductase (EC 1.8.1.14), as characterized in Staphylococcus aureus, Pyrococcus horikoshii, and Borrelia burgdorferi, and inferred in several other species on the basis of high levels of CoA and an absence of glutathione as a protective thiol. [Cellular processes, Detoxification].	9.13543e-108
NC_012918.1\|WP_015837354.1\|2391547_2392897_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NC_012918.1\|WP_015837338.1\|2369405_2369786_-\|lactoylglutathione-lyase	gnl\|CDD\|319940	cd08352, VOC_Bs_YwkD_like, vicinal oxygen chelate (VOC) family protein Bacillus subtilis YwkD and similar proteins. uncharacterized subfamily of vicinal oxygen chelate (VOC) family contains Bacillus subtilis YwkD and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.01882e-17
NC_012918.1\|WP_015837350.1\|2385080_2388218_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|226220	COG3696, COG3696, Putative silver efflux pump [Inorganic ion transport and metabolism].	0
NC_012918.1\|WP_015837337.1\|2368997_2369369_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|334450	pfam01243, Putative_PNPOx, Pyridoxamine 5'-phosphate oxidase. Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as yeast YLR456W and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.	1.21077e-13
NC_012918.1\|WP_015837339.1\|2369852_2371049_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.47159e-08
NC_012918.1\|WP_015837344.1\|2376750_2379264_+\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_012918.1\|WP_015837353.1\|2390312_2391551_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|236674	PRK10364, PRK10364, two-component system sensor histidine kinase ZraS.	9.37742e-66
NC_012918.1\|WP_043578626.1\|2368549_2368882_+\|cytochrome-c	gnl\|CDD\|184253	PRK13697, PRK13697, cytochrome c6; Provisional.	1.49661e-09
NC_012918.1\|WP_015837349.1\|2383445_2384843_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|379862	pfam16576, HlyD_D23, Barrel-sandwich domain of CusB or HlyD membrane-fusion. HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.	1.25438e-105
NC_012918.1\|WP_015837342.1\|2373323_2376128_+\|aconitate-hydratase-AcnA	gnl\|CDD\|236445	PRK09277, PRK09277, aconitate hydratase AcnA.	0
NC_012918.1\|WP_015837348.1\|2382149_2383421_+\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	1.33851e-29

>NC_012918.1|WP_015837345.1|2379268_2379490_+|hypothetical-protein
MDLTQIIVTIAGAALIAFNLWFFFGKKDAGHASAKGKGGLYACPMHPWITSNDPTADCSICGMKLVRSDDVGK
>NC_012918.1|WP_015837344.1|2376750_2379264_+|heavy-metal-translocating-P-type-ATPase
MSENKVLRDPVCGMDVPGDAPHSATHDGTTYKFCSAGCQEKFEANPESFLVAAAPLASETPAAAEAPSAAAGATEHAEKCEFPLLGMNCAGCAGRIEKTLSGSPGVAKAAVNFATTRATIKYDPQVTSPQALKQVVRDMGYDVLEAGSGGAETDEAELLEAQSRVHEEQYLKNRGKFLVALALTIPVAVLAMAGHLIPSLADAFDFPGRAWVELALTTPVLFWAGREFFTGAWSAAKHRVADMNTLVALGTLSAYLFSVVATVAPQWLSARTAAAAGQGHDGEVGVYYEVAAIIVTLILMGRLLEARAKSKTSGAIHALIGLQPKLARVLRDGTEQDIPIAQVLLGDTILVRPGEKVPVDGELIEGSSTVDESMLTGEPLPVRKNEGDTVIGATLNKTGSFRMRATRIGKDTVLQQIVRLVQQAQGTKAPIQRLADLIAGYFVPVVISLAIATFVVWFDISPPDTRLNMAVLTFVSVLIIACPCALGLATPTAIMVGTGRGAQGGILIKGGEALETAHKLTTIVLDKTGTITRGVPSVTDIETGGFERQALMQLAAAAEAGSEHPLGEAIVRYADENGLIRLAARDFNAIPGHGIEATVDGKRVVIGTALLLEKEGIAADTAAAHRLADQAKTPIFVAVDGAYAGVIAIADPIKESSAAAVKRLHDLGLEVIMLTGDNRRTADSIARQVGVDQVIAEVLPDAKGEEIKKLQAQGKVVAMVGDGINDAPALAQADVGIAMGSGTDVAIEAADITLVRGDLNGVISSIALSRATIANIKQNLFFAFVYNIMGIPIAAGVLYPLTGWLLSPIIASLAMALSSVSVVTNALRLRGFTVERG
>NC_012918.1|WP_015837343.1|2376442_2376733_+|metal-sensitive-transcriptional-regulator
MTQSPKNKMTTRVKRIAGQVAGIERMLEEKRYCVDILNQISAVRSALDALGVELLTRHLENCVIGQGTDSQHESAKPMSQQALLDEVKTALSRFLR
>NC_012918.1|WP_015837342.1|2373323_2376128_+|aconitate-hydratase-AcnA
MSGTTSNSYNTLSTLTAGGKSYRYHSLQAFEQNSGLDISRLPYSLKILLENLLRREDGVVVKREDIEAVARWDAAAEPDKELQFMPARILLQDFTGVPAVADLAAMRSALARLGGSPSHINPMQPADLIIDHSVQVDLYGTTGALWGNSSIEFERNHERYQFLRWGQSAFRNFSVVPPATGICHQVNLEYLSQVAMVAKTGDEDWVFPDTLVGTDSHTTMINGLGVVGWGVGGIEAEAAMLGQPCSMLIPQVVGFRLTGALAPGATATDLVLTVTQMLRKKGVVGKFVEFFGPGAASLTIADRATIGNMAPEYGATIGVFPVDGQTTEYLRLTGRGDIVPLVEAYYQQQRLWHDVNQPEPLFSDILELDLAQVEPSLAGPMRPMDRVNLKEVRASFRKQLITLRSHDAARVDKETMSRWLGEGGAPVTVAPELMEHPDKSLGALGHCVPVRQPDGTAYNLCHGSVVIAAITSCTNTSNPSVMIGAGLLARNAVRRGLQVRPWVKTSLAPGSKVVTDYLTAAGLTPYLEALRFHLVGYGCTTCIGNSGPLAEHISGAIVKGDLAVAAVLSGNRNFEGRINSHVRANYLASPPLVVAYALAGNVSIDLTLDAIGSDPNGNPVYLKDIWPNEQEVAQLVQSCVHAESFARNYADVFHGDEQWMALQVPTGELYQWQEGSSYIKEPPFFADLAREPQPVRDVKEARVLALLGDSITTDHISPAGSIGKESPAGRYLISLGIPPKEFNSYGARRGNHEVMVRGTFANTRIRNKLVPGVEGGLTQCFVGEDAGGGRMSIYDAAEKYRAAGVPLVVIAGKEYGTGSSRDWAAKGTKLLGVRAVIAESFERIHRSNLVGMGVLPLQFLPGENPATLGLDGTENFDLEGLAELAPGQKLKVNYRKSDGAAGTFTVQVRIDTTNELDYYRHGGILPFVLRQFLK
>NC_012918.1|WP_015837341.1|2371781_2373116_+|NADH-oxidase
MKTVIIGGVAAGLSAASQAKRLSPESEVVVLEKTGDVSYAACGMPYNLFFKEKPVEKLYALSLETIRKERGIDYRLRQEVTGIDPVGKVVSVTDLATGKSYEERYDFLVYATGNSAIRLTAPGFDDGDVFCFKTLDDTRHVKQFIYDKAPKRAVLVGAGYTNLEVADVLTNMKIKPVILEKAPTILPSFCEEAREKVMEKVKERGVELITGVDIAEKAGGEVRSSAGVFPADLVVVAVGTRPNTALFAAAGGELGTAGAAKVDRYLRTNLDSVFAGGDCAEHYVRQLGMNSYFPLGPAANKHGRVIGSNVSNPDHMMEFWGIDQTAVFKFFELSVATTGLNERQLLALGKDFVKVAVDNPTRGEFPGGSTMRVILFCQKGDGLLLGAQIVGEDVVAKRLDVLATAIYKQMTVFEIAELDLAYAPPYSPVWDPILVAANVAVKKV
>NC_012918.1|WP_015837340.1|2371542_2371701_+|rubredoxin
MKKYRCTVCGYIYDPETGDLDSGIQPGTAFEDIPDDWVCPLCGAEKSLFEEM
>NC_012918.1|WP_015837339.1|2369852_2371049_-|MFS-transporter
MKRLLGKIDEGLLTSEQRPMLRFLIILTAASTIGLQGYTILFNNFAAEMVHLDGSQVGMTQSVREIPGLLTLLVVFVLLFMREHKLAALSVLLLGLGTGITALIPSYGWVIFTTVVMSFGFHYFETTNQSLTLQYFSTAVSPIIFGRLRALAAVSSVAAGIMVYCLSSVVQYRGMYLAIGVVVFIAGAWGLCQNPTHSGIVPQRKKMILRRRYSLFYILTLLSGARRQIFVVFSILLLVQVFHFTVREMTILFIVNNIVAYILNSLIGKAINRFGERFISSCEYAGVIVIFLVYAFSTSRYLVMFMYILDNILYNFEVSIRTYFQKVADPADISSSMSVGFTINHIAAVFLPALGGYFWMLDHRIPFIGGTVLGVISLIAAQWMRVPEKVQKHELAAS
>NC_012918.1|WP_015837338.1|2369405_2369786_-|lactoylglutathione-lyase
MFKRIDHVEIIPRDFERSIVFYTEILGFGIKERMAVSAPPLEEIAYLALGDTVLELMRVKDPTLSAAEPWSTGYRMMALEVEDMDRALEYLAGKGIDPSWGPVTLGPSKRAEIHDPDGLPIELRQW
>NC_012918.1|WP_015837337.1|2368997_2369369_-|pyridoxamine-5'-phosphate-oxidase-family-protein
MIPEKMKEVMKHEGVVAIATQGEDGPHLVNTWNSYLAIDADGRLLIPAGYMHVTEKNVVRNPKVLITLGSREVQGAHGPGTGFLVEGDARFITSGPVFETTKSTFPWARGVLEITISNVTQTL
>NC_012918.1|WP_043578626.1|2368549_2368882_+|cytochrome-c
MKKVVVVSVSVLSLAVMAVPGFCEAKKADKVDGKAKFDQHCAVCHPKGGNIIKSDRPLGKKSLAAHGIKSEKDIVAKMRNPGPSMTKFDAKAVPDAEATAIAKYILATFK
>NC_012918.1|WP_015837346.1|2380012_2381173_+|ABC-transporter-permease
MKLHTISINNLKRRKAKMAFLTIGLMVGIATIVTLVTLTNSMSTDIERKMEEFGANILVTPQSNGLAMNYGGISLGGITFDQREIKEEDLAQIRKIKNQKNIAVISPKVLGGIKVGSQDVLLVGVDFASELKMKQWWQIFGDAPKGDNELLLGSDASNVLDAGSGDSIQIKGETFKVAGVLNQTGSQDDSLVFASLPKAQKLLGKEGKITMAEVAAHCSGCPIGDMVTQIAEKLPDTKVSAIQQVVEGRLKALDHFKRFSYAMAAVVVFIGSLIVFVTMMGSVNERTTEIGVFRAIGFRKSHIMRIILLEAALVSLLAGLLGYAAGMGGAKLALPFMAETKNAHLVWDSTVAFGSVGLAVLLGLLASLYPALHASKMDPTEALRAL
>NC_012918.1|WP_015837347.1|2381185_2381854_+|ABC-transporter-ATP-binding-protein
MALIEIKDVKKQYQTGSDTVEALRGVNISIEAGEFITIMGQSGSGKSTLLSVLGGMNHPTSGEVEMAGVKLYQLPSEKLADFRAQNLGFVFQSFHLIQYLTALENVMLPLAIVKMSTAAKKDAARSALERVGLGGKADRLPNQLSGGEQERVAIARAIVNNPHILLADEPTGNLDSKTSEEVMALFRQLNEAGQTVVMVTHNPENGTYSDRTISLRDGLVSA
>NC_012918.1|WP_015837348.1|2382149_2383421_+|TolC-family-protein
MKHRLLSFYLLLALFLPVPKTHAEPAPPVENLPTLVETALAQNPELKSSAARWQMYRSRAAQAGALEDPMLMFKIQNGIVTDPLSFTADGMTQKVIGISQQLPFAGKRKLKEEIASKEAETYRWSIEERKLELTRMVKEAYYQIYFTDKSQGILDKNIRILDDFIALAQTKYSVGQGAQQDIYKALLERSRMLDMKITLEQQRRSLEANLNSLLNRPQSTPVGRVADFKLAPLSQTPEQLWETAEANRPQLKALRAQIERGRAGHELARKESYPDFNVSFEYMQRQKAMGSDGSDMYSLGVTFNLPIQKERRQAMVAESSSEVTMAGEELAGVKNTITAGIADLLAQLDRRKKLVELYSSGIIPQASESLESAVIGYRVNKVDFLTLLDNRVTLFNYEREYYDSMADYQMKLAQLEALIGKEL
>NC_012918.1|WP_015837349.1|2383445_2384843_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MKRSVKVAIPIVVILVAAVAGGGYYLAQKKTPPAAKDKAAQGPVLYTCAMHPFIIKDKPGTCPICGMQLIKKVEGAQASAQEQKMLGHVSLSPTQQIMANVATVPADFAPLSKEINAVGIVQYDQSKQAKVTAWVAGRIDKLIVNTVGAYVSKGRPVAEIYSPDLVAAQQEYLLALKSREQFQKSSIQAISQGGEGLVSSARQRLKLMGVRDEQIARLEKAGHPNIKLPIYTPLSGVVIEKMVQEGQYVDLGMPLFSIADLSRVWVEVEVYENEFAFVKMGQRVEILSQSYLGKTFSGRVSFIYPFLDPKTRTVKVRVELANPGLKLKPDMFVNAQIKAPLGNTLVIPTTALMDTGKRQVVWVESQPGMFEPRDVQVGARVGDKVQILSGLNRGDKVAASGGYLIDSESQLSAGSGGGGGHEGHAGGATAPGAAAPAPAAPAAPGTGTPAAPKKNGAMNMDDMKM
>NC_012918.1|WP_015837350.1|2385080_2388218_+|efflux-RND-transporter-permease-subunit
MIEKIIEYSARNRVIILMMFALIIAWGVWSVYKTPVDAIPDLSDNQVIVFTDYPGRSPQVVEDQVTYPLAVNLQGLPQVRAVRASSAFGFSMIYVIFEDKADIYWARTRVLERLNYAASLLPPGVVPTLGPDGTGVGHVFWYTLEGKGYDLEQLRTLQDWFVRYQLNTVPGVAEVASIGGFVREYQVDLDPNRLFAYNIKVSQVADAIKKSNNDVGGRLLEQADAEFLIRGRGYVKSTTDLENIVVGADMRGTPIYVKNLGTVQLGGAIRRGMLDMNGEGEAVGGIVVMRYGENAKDVIDRVKEKIVSLEKGLPPGVKIMVSYDRSDLIERAIHTLKASLIEESIVVSLVILVFLLHFQSALVIVLTLPIAVLFSFITMKLMGVSSNIMSLGGIAIAIGVLVDAGVIMVENCYRHLSEMPPEERKEKRLEVIITSAKQVGRAIFFSLAIIILSFVPVFLLEGQEGKMFHPLAFTKTFSMMGSAFIAITLVPVLMYFLMRGKMPPESANPVSTFFIKMYSPVIRWVLKWKKTTIALNVAALLIAIPMFMSIGSEFMPPLDEGSLLYMPVTLPNVSINEAKRLIQVQDTVIKSVPEVEHVLGKVGRAETSTDPAPVSMFESIIILKPKDKWRAGVTKADIVSELDAKLQQIGVRNGWTQPIINRINMLSTGVRTDLGVKIFGADLNVLKDLAVQAEGILKTVPGAADVVAERVTGGNYIDIDIDREAAARYGVNVGDVQEVISMALGGEMLSTSVEGRNRFPIRLRYMREMRSDIPSIQRILVSGMDGAQVPLSLVTKLKVSTGAPEINSEGGLLRSIVFLNVRGRDMGGFVNEAKTVLEKQMKLPPGYYVAWSGQWENQVRAKARLQMLVPAGILIIFILLYFTFHSAIEASMVMLSVPFALVGGVYLVKMLGYNMSVAVWVGFIALYGIAVETGVVMVIYLHEALDKKLINGPCTEQDIYDATFEGAVLRLRPKLMTVAVALLGLVPIMWSTGTGADVMKPIAAPMIGGMISSAVHVLIMTPVIFVLMKKHDLKKGKLKYSGMKH
>NC_012918.1|WP_015837351.1|2388364_2388826_+|hypothetical-protein
MKKLVVLIAAAFALSAPMAALAMEHGSMKMEHGHDAGVAHEEVVKGVKATFKVMSMKEHMKAMKMEMPKGMKETHHIAAEFKDAKTGKALTEGEVTVKVQSPDKSAQTKDLMGMEGHFGADFDLSKKGKYGVMCKFKLKDGQVRSSKFWYTVK
>NC_012918.1|WP_015837352.1|2389351_2390218_+|GerMN-domain-containing-protein
MRYLRSFILFLAVTALAACNASERQPAETEKPGSVKATKAFVKEFGPAPAVEKGTAYAFVIYFPSAKQPGKVIPFPFFSFDEASLKKVALAKLIGGLGDLKSYQGEIAQPFPVGARLLDLQQAGESVTAVFSKELAGAGSDQGLVNAVVLTLKQFEGVGRVAIRVEGAPESTDKQAQKADESAVLPLAPPRLLNVTGMKEKGAATVEEVDAFFDRPVQIKELQLFDAGGKPFEGEIYHSVFDMAGVLKPKSPAKFSAGLPVQVRWNVTDKMGRNSSGQTEMMLEVREH
>NC_012918.1|WP_015837353.1|2390312_2391551_+|two-component-sensor-histidine-kinase
MFRKATLIIGIFATCSLLWFTVYNYRQAGPIAEENLRGLALTLSSAIENLAVNDPSLAALAKFRTNDIAYFALVDRQGLFRFHSNPDLIGASLPGAGRKAAPSLERSESRVTLGTGEQAFLVTAPINLSGETLALHLTLHTYRADAVVRSAKLNLIIMLALIAAGWLLSLGLFRYARREELHQAEMTRKGNLAKLGEMGALLAHEIRNPLAGIKGFAQVIAKKPQEARNGAFAENIVIEVVRLETLVNDLLAYAAGDGAQPARFDLGQLIDHALSLLAPEAAERAVAVSCSSTGSLFVMGNRDRIEQALLNLGKNALQAMGAGGVLEIACATAGGEARISIKDTGQGIAEADLPKVFEPFFTTKARGTGLGLALCRKVIEEHGGTISLESRVGEGTTVTFALPILPADKEQT
>NC_012918.1|WP_015837354.1|2391547_2392897_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MKGNILVVEDDDTFRAFLETVLQDDGHQVKTAADGEKALGLLRQGSYDLVVSDLKLPGKSGLDLFRETRNDPAAPQFIFLTAYGKVGEAVAAIKEGAVDFLTKPLQDPEVLLRLVRHVIDEQLRERDYLSLKQCEAAGLPPEDLIFAGQAMGPVRKLVHDVAGTMANVLVFGESGTGKELVARIIHQLSSRRNAGFVALNCAAIPETLLESELFGHEKGAFTGAVQARQGKFELARGGTILLDEIGEMPLALQAKLLRVIQERVFERVGGTKEIKADVRLIAATNRNLREEVAQRRFREDLYYRLNVFPVQLPSLRERADSVPVLARYFMQRFSSQTGKALKGIDSDALAALERYRWPGNIRELQNVMERAVILSRDRVGLAALPEEMLRKPEPDALDSRERLKSAEREIIAEAIRKHGGNRRLAAEELGVSRRTLQYKLKEYGFLEES
>NC_012918.1|WP_015837355.1|2393308_2393851_+|hypothetical-protein
MKRFSLILIFAVLLNCQLLGQASAGFFGFGSEDKGKSGLDFSRGYDLNTVGTVSGRVTTLPRIAENEQYVIEIESGSETVSLSVGPENFWEKKGIPVKVDDEITAKGSRAQGRDGKTYLLTQKLVNRSTGKQLEIRSDRGEPAWSGRSAAGAAQMRGGIGFQGGGFMRGGGMMGGGMMRR

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Crispr_ID: NC_012918_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012918_8

3005122-3005257

Orphan

Consensus_repeat	Method
TTTTATCCCTTTTATCCCCTTCATCCCTGTTAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012918_8

>merge|NC_012918|8|3005122-3005257|CRISPRCasFinder
TTTTATCCCTTTTATCCCTTTTATCCCTTTTATCCCCTTCATCCCTGTTAAAACAGATAAAGATAAAGATAAAGATAAAGGTTTAAACCAATCTTTTGGTTGGTTTTATCCCTTTTATCCCCTTCATCCCTGTTAA

>NC_012918|8|8|3005122-3005257|CRISPRCasFinder
TTTTATCCCTTTTATCCCTTTTATCCCTTTTAT	CCCCTTCATCCCTGTTAAAACAGATAAAGATAAAGATAAAGATAAAGGTTTAAACCAATCTTTTGGTTGG
TTTTATCCCTTTTATCCCCTTCATCCCTGTTAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012918.1\|WP_015837847.1\|3007443_3008106_-\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|179661
NC_012918.1\|WP_015837852.1\|3012555_3012933_-\|GxxExxY-protein	unknown	unknown	gnl\|CDD\|275083
NC_012918.1\|WP_015837839.1\|2998354_2999275_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NC_012918.1\|WP_157506155.1\|3009210_3010623_-\|capsule-assembly-Wzi-family-protein	unknown	unknown	gnl\|CDD\|379441
NC_012918.1\|WP_015837846.1\|3006308_3007184_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|132060
NC_012918.1\|WP_015837840.1\|2999738_3000407_+\|serine-O-acetyltransferase	unknown	unknown	gnl\|CDD\|200082
NC_012918.1\|WP_015837841.1\|3000743_3002033_+\|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB	unknown	unknown	gnl\|CDD\|273704
NC_012918.1\|WP_015837835.1\|2992214_2993864_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236236
NC_012918.1\|WP_015837853.1\|3013069_3015013_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224011
NC_012918.1\|WP_015837836.1\|2995207_2996173_-\|D-2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240639
NC_012918.1\|WP_015837844.1\|3005321_3005600_-\|YcgN-family-cysteine-cluster-protein	unknown	unknown	gnl\|CDD\|235356
NC_012918.1\|WP_015837837.1\|2996184_2996775_-\|DUF502-domain-containing-protein	unknown	unknown	gnl\|CDD\|225480
NC_012918.1\|WP_015837848.1\|3008259_3008547_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837838.1\|2996987_2998358_+\|S41-family-peptidase	unknown	unknown	gnl\|CDD\|223864
NC_012918.1\|WP_015837849.1\|3008751_3009006_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_049760119.1\|2994519_2995284_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837842.1\|3002029_3003250_-\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|226702
NC_012918.1\|WP_015837843.1\|3003760_3005020_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837845.1\|3005610_3006285_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_012918.1\|WP_015837851.1\|3010860_3012492_-\|capsule-assembly-Wzi-family-protein	unknown	unknown	gnl\|CDD\|379441

Protein	Function_ID	Function_description	E-value
NC_012918.1\|WP_015837847.1\|3007443_3008106_-\|adenylyl-sulfate-kinase	gnl\|CDD\|179661	PRK03846, PRK03846, adenylylsulfate kinase; Provisional.	1.23097e-107
NC_012918.1\|WP_015837852.1\|3012555_3012933_-\|GxxExxY-protein	gnl\|CDD\|275083	TIGR04256, conserved_hypothetical_protein, GxxExxY protein. Members of this protein family average about 130 residues in length and include an almost perfectly conserved motif GxxExxY. Members occur in a wide range of prokaryotes, including Proteobacteria, Perrucomicrobia, Cyanobacteria, Bacteriodetes, Archaea, etc.	8.69492e-58
NC_012918.1\|WP_015837839.1\|2998354_2999275_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	3.09761e-112
NC_012918.1\|WP_157506155.1\|3009210_3010623_-\|capsule-assembly-Wzi-family-protein	gnl\|CDD\|379441	pfam14052, Caps_assemb_Wzi, Capsule assembly protein Wzi. Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation. This family plays a role in group 1 capsule biosynthesis. It is likely to be involved in the later stages of capsule assembly. It is likely to consist of a beta-barrel structure.	2.85033e-63
NC_012918.1\|WP_015837846.1\|3006308_3007184_-\|AAA-family-ATPase	gnl\|CDD\|132060	TIGR03015, pepcterm_ATPase, putative secretion ATPase, PEP-CTERM locus subfamily. Members of this protein are marked as probable ATPases by the nucleotide binding P-loop motif GXXGXGKTT, a motif DEAQ similar to the DEAD/H box of helicases, and extensive homology to ATPases of MSHA-type pilus systems and to GspA proteins associated with type II protein secretion systems. [Protein fate, Protein and peptide secretion and trafficking].	5.82314e-94
NC_012918.1\|WP_015837841.1\|3000743_3002033_+\|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB	gnl\|CDD\|273704	TIGR01579, MiaB-like-C, MiaB-like tRNA modifying enzyme. This clade of sequences is closely related to MiaB, a modifier of isopentenylated adenosine-37 of certain eukaryotic and bacterial tRNAs (see TIGR01574). Sequence alignments suggest that this equivalog performs the same chemical transformation as MiaB, perhaps on a different (or differently modified) tRNA base substrate. This clade is a member of a subfamily (TIGR00089) and spans low GC Gram positive bacteria, alpha and epsilon proteobacteria, Campylobacter, Porphyromonas, Aquifex, Thermotoga, Chlamydia, Treponema and Fusobacterium. [Protein synthesis, tRNA and rRNA base modification].	6.08027e-150
NC_012918.1\|WP_015837835.1\|2992214_2993864_-\|AMP-binding-protein	gnl\|CDD\|236236	PRK08315, PRK08315, AMP-binding domain protein; Validated.	0
NC_012918.1\|WP_015837853.1\|3013069_3015013_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224011	COG1086, COG1086, Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	0
NC_012918.1\|WP_015837836.1\|2995207_2996173_-\|D-2-hydroxyacid-dehydrogenase	gnl\|CDD\|240639	cd12162, 2-Hacid_dh_4, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	1.98188e-175
NC_012918.1\|WP_015837844.1\|3005321_3005600_-\|YcgN-family-cysteine-cluster-protein	gnl\|CDD\|235356	PRK05170, PRK05170, YcgN family cysteine cluster protein.	3.6995e-40
NC_012918.1\|WP_015837837.1\|2996184_2996775_-\|DUF502-domain-containing-protein	gnl\|CDD\|225480	COG2928, COG2928, Uncharacterized conserved protein [Function unknown].	3.56464e-60
NC_012918.1\|WP_015837851.1\|3010860_3012492_-\|capsule-assembly-Wzi-family-protein	gnl\|CDD\|379441	pfam14052, Caps_assemb_Wzi, Capsule assembly protein Wzi. Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation. This family plays a role in group 1 capsule biosynthesis. It is likely to be involved in the later stages of capsule assembly. It is likely to consist of a beta-barrel structure.	1.64723e-126
NC_012918.1\|WP_015837838.1\|2996987_2998358_+\|S41-family-peptidase	gnl\|CDD\|223864	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane].	5.30197e-129
NC_012918.1\|WP_015837842.1\|3002029_3003250_-\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	1.33626e-44
NC_012918.1\|WP_015837840.1\|2999738_3000407_+\|serine-O-acetyltransferase	gnl\|CDD\|200082	TIGR01172, Serine_acetyltransferase, serine O-acetyltransferase. Cysteine biosynthesis [Amino acid biosynthesis, Serine family].	3.92603e-97
NC_012918.1\|WP_015837845.1\|3005610_3006285_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.59133e-05

>NC_012918.1|WP_015837843.1|3003760_3005020_-|hypothetical-protein
MASVENRQVAAARLSQGDFQALPLDKKGKYLKTAPAREKMELIIADPDAKRVAATLEPQEFFWLVKEVGETDALELLQVASADQCVFILDMEAWEGWTFSEEQVHHWLEKFMEGGEPRVHELLKHLDFDLLQLFLSREIEVGGGIGDQSNDQERLAEYDHTFDGVFMINFKNPKHSQLVGTFLSMLIKLDNSLYTALMEGAKGEVDLELEEQCQRFRTGRLQDLGFPPLDEALSIYARVNPEHFHLEGGKELSPAGEGGQLVPVGADEGTFFSRALALAATPTLYQELNYLVNSALVAEGNAFHEPETMLAILHRVSGYLNIALERLAPADEQRAADILVSEELKRLFQLGYSIVLQLKFSARDVETADYASGKLLAGLKTKRPRFYRGLDPDGVDGYREFRDLSDVQRVADLLAQLKP
>NC_012918.1|WP_015837842.1|3002029_3003250_-|hybrid-sensor-histidine-kinase/response-regulator
MKVLVVDDSRNDRKIIRYNFEWHGCEVLEASNGKQGLELAAAEKPDLIVSDCLMPVMDGFQFLHEIKKFQDTKTIPFIFYSAVYTGSREAELAASLGARAFLAKPMRPEELWDEVGRLMAAEPAGEAVERKPWPEEEFLKNYSQLVAGKLEEKVRELTETNESLLRLNSELERRVVERTSQLEAANRELDMFSYSISHDLRAPLRHLEGFSQALIDEYATKLNHTGREYLERLRKSARRLTDMIDALLELSRHTRGKLVKESVDLTSIAKEVAAQLARSQPERKVSMEVAEGMMVRGDSRLLKVVLEQLIGNAWKFSQPRGEEALVEVFPTELEGRPACAVRDNGVGFEMEYADKLFSPFQRLHAQDEFPGRGIGLAIAKRIITRHGGKMEAQAELGKGATFTFSV
>NC_012918.1|WP_015837841.1|3000743_3002033_+|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB
MSKTIAITTLGCKINQFESAAMTQALEQNGYSMVPFSAKADIYVVNSCTVTAKTDAESRRLIRRATRLNPEARVVVTGCYAQMNGEELLKLAGVNLILGNSEKKDIVGFLEGLDDQPRAVVSDISLEKTGETAPLETFAEHTRAFLQVQNGCDARCAYCIVPFARGASRSVAVQEALDGMAAFAAQGFQEIVLTGIHLGAYGLDLAPPTDLLGLMRKAQDQGAVRRLRIGSVEPTEVSRQLIDFMGTSTIACPHLHLPLQSGSDSVLSRMNRGYDTALFAEVVHSLVSAMPEVCIGSDVIAGFPGESDREFDETYRFIDSLPLAYLHVFPFSQRPGTPAATMTPQVNPKVIKERAEALRVLSERKKSDYAAGFVGRELQVLVQRGEKGLSRNYLTVLVEDSEGLVNREVTVLVTGAKGGELTARVLKES
>NC_012918.1|WP_015837840.1|2999738_3000407_+|serine-O-acetyltransferase
MFSRIKSDIQAVFDRDPAARSVLEVIFCYPGLHAIWFHRISHWFWKHEFWFLGRFTSHIGRFLTGVEIHPGATIGQGFFIDHGMGVVIGETAEIGENVTLYHGVTLGGVSWEKVKRHPTLMDNVVIGSGAKILGPFTVGKDSKVGSNSVVVKEVPPNSTVVGIPGRVVMATEKPQERLDLEHGKMPDPEAKAISCLFDQIRELERKYTALAAEHEALKKKLG
>NC_012918.1|WP_015837839.1|2998354_2999275_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MTTASDLTGRIPNLLVILGATASGKTRLGVQLSGRLNGEIISADSRQVYRGMDIGTGKDLHEYQGIPYHLIDVAPAGHEFNLFQFQRLFLAAFADIRSRGGFPVLVGGSGMYLDCVLRGYRLVEVPEDPALREELAPLSMEELASRLTRSNPRLHNSTDLTERARLVRALEIAEYRGGGSDNWPEIAPFIIGIRWERAQLRERITKRLKERMEQGMVEEVERLHAMGTSWEQLEFYGLEYRYLARYLKGELSRNDMFQKLNSAIHDFAKKQENWFRKMQTNGTAINWVEGAGDPLAQALELLAKNR
>NC_012918.1|WP_015837838.1|2996987_2998358_+|S41-family-peptidase
MSKKVFAAFAVIFLLLSLVLMLPLLDREERAKRSEAEYLEMFREVVNIVKQSYVDKVDDKKLMAGAINGMLATLDPHSTYLPATDYTEMKVHMAGAFGGLGIELEMRNGKLMVNAPIEDTPAFRAGIQSGDHIWTIDGKPTADLNINQCVSRMRGTPGTSVTLGIMREGKPSPLTFRLVRAIIKTKSLKGRLLEPGYGYIRIGEFQERTGEDFEKALKTLAADNGQPLSGLVLDLRFNPGGLVDQAYRVANRFIGEGLSSGVIVTTKGRDPSMERSLTATVGDKEPRYPIVVLINGGSASASEIVAGALQDQKRAVIMGTQSFGKGSVQSVMTLDNGDGLKLTTARYYTPSGRSIQAKGITPDIVVEFAKPAPPAKDKQKGEKELEIREQDLDGHMDQAPAPTRPANPHQAPPPSPSLKPSGKEVKEQDLLKADNQLARALDLLKGVNLLQASGRR
>NC_012918.1|WP_015837837.1|2996184_2996775_-|DUF502-domain-containing-protein
MEKMIRHFKGRFITGLFVVVPLGITIFILKFLFNFADGILGSYLDSLLSAFLDNPYHIPGLGMLTGAIVIYVSGVLATNVIGTRIIRWWDKLLCRIPVVKSIYGSSKQLTQVFKEGKSSYRRAVFVEWPRPGVRAVGFVTAEVEREGEKLVVVYVPTMPNPTSGFALFFKEAEVRDCGMSVEDAVKFVVSGGAVVQ
>NC_012918.1|WP_015837836.1|2995207_2996173_-|D-2-hydroxyacid-dehydrogenase
MKMVVLDGYTLNPGDNPWDEVASFGELTLYDRTPAEMVLERSRGAQVLLTNKTVLSAATLAALPELRLVCVLATGYNVVDLEKSAQLGIPVVNVPEYGSDSVAQHAIALLLELTNRVAHYHRAVARGDWSASPDFTLVGEPLTELCGKSIGIVGLGRIGARVARIAQALGMEVLAYNPRHRVAPEGISLRWLGLDQLFSQADVVSLHCPLNNENEGMVNRRTLSLMKPQALLINTSRGGLVVERDLAEALNSGSIAGAAVDVAAREPIPADSPLLGAKNCIVTPHIAWATLAARKRLMAATAANIASFLAGKPRNVVNGVQ
>NC_012918.1|WP_049760119.1|2994519_2995284_+|hypothetical-protein
MVKRILAAAVVLSLGTAGVSEAAANNKRSNGKKASSSGYAVISPIFSQLVSFTLPVGFTTVWEDGDRTNYLREAVPAGETIESWTQMVTVTGAKGLSGNPNVTPRSFASAIAGGFEKACPNTYSDKILKEGKNERGYDEFVAVVSCGATPGGSGISSESALIVVIKGERDYYTVHHLVHLMVPLVPKVHLGNARPMRSSSFPGCKAGALRRMGSQAGAWEPGETSTGNLLTVPRSPRFAVSPPETRRCWRRWPP
>NC_012918.1|WP_015837835.1|2992214_2993864_-|AMP-binding-protein
MSQQIELTVGALLDDIAGKFPDNEALIYVERGLRYSYREFNERCRQVAKGLLRMGVRKGDHLAIWAYNVPEWVVLQFASAKIGAVLVTVNTSYKSAELEYVMKQSDSSFLFLVQGFKDTDYIRTLTDVVPELSESEPGKLESRDLPCLKHVVFLGEGAPAGTINFEKIVELGRDVPDAELHAVEKTLSVHDVINMQYTSGTTGFPKGVMLTHHNVVNNGFNIGECMRFTEKDRLCIPVPFFHCFGCVLAVMACVTHGSTMVPVEIFDPLKVLQAVEKERCTALHGVPTMFIAELEHPRFSEFDLTSLRTGIMAGSNCPIEVMRRVIRDMHAGEITIAYGQTESSPVITQTRTDDPIELKVSTVGRVLPDVELKIVDIESGAELPPGKQGELCTRGYLVMKGYYKMPEETAKAIDADGWLHTGDLAVMDEHGYCKITGRIKNMIIRGGENIYPREIEEFLYTHPKISDVQVYGVPDRKYGEQVMAAVVLKQGSEMSETEVKEFCRGRIANYKIPKYVRFVDSYPMTASGKIQKFKLREMAIRELQLEENV
>NC_012918.1|WP_015837844.1|3005321_3005600_-|YcgN-family-cysteine-cluster-protein
MSGGKSNREQWEGLCEQCGLCCFEKIEDEDGRILFTSTPCRYLDIDTRRCKIYEKRFKIFPECVELTPELVKELKWLHRSCGYKKAMKKGII
>NC_012918.1|WP_015837845.1|3005610_3006285_-|hypothetical-protein
MSSILKALEKVEDAQNQKRNPGAGGLGRKRERRPAWLIPAWSLGGAAVATLVTYSIMGGFGKPAPPAAQVVATAPQPAARPAAPVAEAAVSTAPVATEKPVAAPVKSRQTRDEVKAPVRKQQVGSVPKLAAKPQRSLKVPEPPVSARPAAVHAAPALVAPPQEIRVTGIAWQNDSQSSFAMVNGRPVRQGAVVDGYKVEQIFEDSVRFTGGKGPVTIPLGAAEQ
>NC_012918.1|WP_015837846.1|3006308_3007184_-|AAA-family-ATPase
MYCEFYGFRESPFTITPNPRFLFLSDHHREALAHLLYAVENRVGFVELTGEVGTGKTTVLRTFLTRLDGRGHRTALIFNPCLSSLELLKSVNREFGLSCDSESRVDLLQVLNEFLLEQKRAGHSVVLVMDEAQNLSPEVLEQIRLISNLETETDKLIQIVLSGQPELLAVLAREELRQLNQRITVRYHLLPMDFENTRRYIDHRMELAGCHRAAEFSVAALKRIFRFSGGIPRLVNVVCDRALLIGFTAESRIISGGMAAQAVSEVAGRAPYGITARVLRRVFGRVPRWLN
>NC_012918.1|WP_015837847.1|3007443_3008106_-|adenylyl-sulfate-kinase
MENIANLMPFERRLTAEHYRARNGHGPMVLWFTGLSGAGKSTLAHIVEEALFAKGCYTYLLDADNLRTGLNSDLGFSDAERRENIRRVGEVARLFADAGLVVLAAFISPFREDRDRVRALFQSHEFVEIYVKCDLEVCEARDPKGLYRKARGGLIPEFTGIDSPYEAPASPELIVDTAALGIAESVGRIMAYLDSLIAVKPAHAKPQSTQRKPTTGMKGM
>NC_012918.1|WP_015837848.1|3008259_3008547_-|hypothetical-protein
MKKDNLEVILEQMNSKFDLVLEGHAVLRSEIRELSRKTDERFDMVDFKIETLNKKIDAVDEKLSKRLDAVAADLSAHRADTEAHHGVYRVMESDS
>NC_012918.1|WP_015837849.1|3008751_3009006_-|hypothetical-protein
MKKENLEVILEQMNSKFDLVFEGHAVLRNEIREVSRKADERFDLVDFKIETLNKKIDAVAADLSAHRADTEAHHGVYRVMESDS
>NC_012918.1|WP_157506155.1|3009210_3010623_-|capsule-assembly-Wzi-family-protein
MRATALMSLCFLLLLSTVAFADSYLPLDSRLYGDLRFLEANGGITTAQLSTLPISRREAARLTSEAIENVAADDSFRVQAALARLKQEFRRELEGDTSAEFVMDTADLQYMYSDDKGFFWQKNRDGVEVRRGHNLFLNATGRFDSKYLGAVVRPEADLYEGDAGLRLKKAYLLANLGREEFVVGKESQWWGTGLNGSPLLSDNAEPLTVFKISNSVPYFPFGIGVRGSFFVTRLEEERTDVDRPILYGMRLDLKPSPWFELGLAKTALLGGEGRNAGLSTFGNSLLALGENEEGEAGDQRAGLDAKVVIPWRVQPITLSVEMTGEDQRNNFPEKWFEVYGIYLPRVLSLERLEVLAEYATNVDGYYKGVWYTHHIYTQGYTYHGRIIGHYIGSDARDLFVRAQYHFDPLILSLSYENLHKVYPESIRWESFEASALTELSHHTDLTVSAGYAREAEKNFIMRMGLRHYFM
>NC_012918.1|WP_015837851.1|3010860_3012492_-|capsule-assembly-Wzi-family-protein
MRFFLVALVVCITSFASSAFALSSANIPLDSPIYLYLEKLSGYGLVSGDVKGIRPFSKAEAVRLLREAETHLASGDHPRLAGEIVQRLRELLPREVALYGDEAKANPLDFEPVAAARLRYVHLDGKPRSYFRAVHDAGHDGVFGIGSGLRPATPYPHPIQQRGYEGTPLFENNDGVVYRSGSNLDLRASGEAYWGSKAALLIEPMLLWSEETDEATLRLNRGYVKFGGKGLELEAGRDENWLGPGYRGAITLTNNARNMDLVKLSSPELVSSKYLWDLKYTLIFSQLEKTVTDGQEREPFFFAGKLSMKPMRNIEFGINLGRQVGGPGVSNSLGDNARGMIGGWNQDNSNTVAGVDLRFRLPWLRNSELYGEFSGEDAAAFWPIVESYVAGFFIPSLTESGRDDLRFEYFRGNEILYSNGTFPAGYLYHGLPIGHSQGGAAEEWFLRYSHWFSVRNNLAVEATHGTRGGYGRMTVDATGAFDPAGVMQAVERRDALRAFWSFPVQGEWSALVMYGHEWINNLELRQGESRKNQLLRVELTYRY
>NC_012918.1|WP_015837852.1|3012555_3012933_-|GxxExxY-protein
MTENEIATVIVDASFKVHKHLGPGLLESVYLAVLAYELEQRDVMVSRQQPMPIIYESVRLDEAYRADLVVNDKVIVELKSVEKIAPVHKKQLLTYLRLSNLKLGLLINFGEALIKDGITRVVNDL
>NC_012918.1|WP_015837853.1|3013069_3015013_-|polysaccharide-biosynthesis-protein
MFRTRRILVFFLDVALIVAAFVLAFLLRFDFQIPADQSSALLQGLLIILVAKPVIFIASGMYRCIWRYASLQDAYEIFKAVTLSSVVSAFTFLFMKGPFALPRSIYFLDWFLLFSMVACSRLLWRVYRETKFLPSLHKGKKTLIIGAGEAGNLLLKEIRKEADSPYNVIGFVDDDIEKRGMRLSGVRVLGGTSRLCALVRKHAIEEVIFAIPSGDRELMRRVIANCERGKARFKTLPGITAIVDGKVSMSQIKDVEIEDLLGRDPVLLDQTAIRNYLTDKRVLVTGAAGSIGSEICRQVARFKPAKLVLFDHAETPLFYIEKELAASFPDLRLIPMVGDVKNQERVEAVFDEFCPEVVFHAAAYKHVAMMEYNPAEAVLNNVLGSRIVADAAHKTKVRNFVMVSTDKAVNPTNVMGATKRSAEIYVQALAAKSQTKFTTVRFGNVLGSNGSVIPLFKEQIKNGGPVTVTHSDVVRYFMTIPEASQLVMQAGCIGRGGEIFVLDMGDPVRILSLAEELIRLSGLVPYKEMDIQFTGLKPGEKLFEELLINGEGIKPTSHKKIRVMAPVETDLRRVSQDFDEMFAHARNQDIGELLKALRRIVPEFVPRYEFDVAPPMAFQRVRPDLFPPQKLTLVRNLQLASKEGSAA

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Crispr_ID: NC_012918_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012918_9

3007375-3007502

Orphan

Consensus_repeat	Method
GGTTTTCTTCGCGTGCTTTGCGGCTTTGCGTGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012918_9

>merge|NC_012918|9|3007375-3007502|CRISPRCasFinder
GGTTTTCTTCGCGTGCTTTGCGGCTTTGCGTGAGAAGGTTTGAAGGCTTTACAGTTTTGCAGTTATCCCCTACATCCCCTTCATCCCTGTAGTAGGTTTTCTTTGCGTGCTTTGCGGCTTTGCGTGAG

>NC_012918|9|9|3007375-3007502|CRISPRCasFinder
GGTTTTCTTCGCGTGCTTTGCGGCTTTGCGTGAG	AAGGTTTGAAGGCTTTACAGTTTTGCAGTTATCCCCTACATCCCCTTCATCCCTGTAGTA
GGTTTTCTTTGCGTGCTTTGCGGCTTTGCGTGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012918.1\|WP_015837852.1\|3012555_3012933_-\|GxxExxY-protein	unknown	unknown	gnl\|CDD\|275083
NC_012918.1\|WP_015837839.1\|2998354_2999275_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NC_012918.1\|WP_157506155.1\|3009210_3010623_-\|capsule-assembly-Wzi-family-protein	unknown	unknown	gnl\|CDD\|379441
NC_012918.1\|WP_015837846.1\|3006308_3007184_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|132060
NC_012918.1\|WP_015837843.1\|3003760_3005020_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837841.1\|3000743_3002033_+\|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB	unknown	unknown	gnl\|CDD\|273704
NC_012918.1\|WP_015837853.1\|3013069_3015013_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224011
NC_012918.1\|WP_015837837.1\|2996184_2996775_-\|DUF502-domain-containing-protein	unknown	unknown	gnl\|CDD\|225480
NC_012918.1\|WP_015837844.1\|3005321_3005600_-\|YcgN-family-cysteine-cluster-protein	unknown	unknown	gnl\|CDD\|235356
NC_012918.1\|WP_015837842.1\|3002029_3003250_-\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|226702
NC_012918.1\|WP_015837854.1\|3015685_3016090_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NC_012918.1\|WP_015837857.1\|3017275_3017953_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837851.1\|3010860_3012492_-\|capsule-assembly-Wzi-family-protein	unknown	unknown	gnl\|CDD\|379441
NC_012918.1\|WP_015837849.1\|3008751_3009006_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837855.1\|3016083_3016341_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|198034
NC_012918.1\|WP_015837838.1\|2996987_2998358_+\|S41-family-peptidase	unknown	unknown	gnl\|CDD\|223864
NC_012918.1\|WP_015837848.1\|3008259_3008547_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837840.1\|2999738_3000407_+\|serine-O-acetyltransferase	unknown	unknown	gnl\|CDD\|200082
NC_012918.1\|WP_015837845.1\|3005610_3006285_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_012918.1\|WP_015837856.1\|3016602_3016833_+\|DUF2281-domain-containing-protein	unknown	unknown	gnl\|CDD\|378366

Protein	Function_ID	Function_description	E-value
NC_012918.1\|WP_015837852.1\|3012555_3012933_-\|GxxExxY-protein	gnl\|CDD\|275083	TIGR04256, conserved_hypothetical_protein, GxxExxY protein. Members of this protein family average about 130 residues in length and include an almost perfectly conserved motif GxxExxY. Members occur in a wide range of prokaryotes, including Proteobacteria, Perrucomicrobia, Cyanobacteria, Bacteriodetes, Archaea, etc.	8.69492e-58
NC_012918.1\|WP_015837839.1\|2998354_2999275_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	3.09761e-112
NC_012918.1\|WP_157506155.1\|3009210_3010623_-\|capsule-assembly-Wzi-family-protein	gnl\|CDD\|379441	pfam14052, Caps_assemb_Wzi, Capsule assembly protein Wzi. Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation. This family plays a role in group 1 capsule biosynthesis. It is likely to be involved in the later stages of capsule assembly. It is likely to consist of a beta-barrel structure.	2.85033e-63
NC_012918.1\|WP_015837846.1\|3006308_3007184_-\|AAA-family-ATPase	gnl\|CDD\|132060	TIGR03015, pepcterm_ATPase, putative secretion ATPase, PEP-CTERM locus subfamily. Members of this protein are marked as probable ATPases by the nucleotide binding P-loop motif GXXGXGKTT, a motif DEAQ similar to the DEAD/H box of helicases, and extensive homology to ATPases of MSHA-type pilus systems and to GspA proteins associated with type II protein secretion systems. [Protein fate, Protein and peptide secretion and trafficking].	5.82314e-94
NC_012918.1\|WP_015837841.1\|3000743_3002033_+\|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB	gnl\|CDD\|273704	TIGR01579, MiaB-like-C, MiaB-like tRNA modifying enzyme. This clade of sequences is closely related to MiaB, a modifier of isopentenylated adenosine-37 of certain eukaryotic and bacterial tRNAs (see TIGR01574). Sequence alignments suggest that this equivalog performs the same chemical transformation as MiaB, perhaps on a different (or differently modified) tRNA base substrate. This clade is a member of a subfamily (TIGR00089) and spans low GC Gram positive bacteria, alpha and epsilon proteobacteria, Campylobacter, Porphyromonas, Aquifex, Thermotoga, Chlamydia, Treponema and Fusobacterium. [Protein synthesis, tRNA and rRNA base modification].	6.08027e-150
NC_012918.1\|WP_015837853.1\|3013069_3015013_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224011	COG1086, COG1086, Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	0
NC_012918.1\|WP_015837837.1\|2996184_2996775_-\|DUF502-domain-containing-protein	gnl\|CDD\|225480	COG2928, COG2928, Uncharacterized conserved protein [Function unknown].	3.56464e-60
NC_012918.1\|WP_015837844.1\|3005321_3005600_-\|YcgN-family-cysteine-cluster-protein	gnl\|CDD\|235356	PRK05170, PRK05170, YcgN family cysteine cluster protein.	3.6995e-40
NC_012918.1\|WP_015837842.1\|3002029_3003250_-\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	1.33626e-44
NC_012918.1\|WP_015837854.1\|3015685_3016090_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	1.93121e-21
NC_012918.1\|WP_015837851.1\|3010860_3012492_-\|capsule-assembly-Wzi-family-protein	gnl\|CDD\|379441	pfam14052, Caps_assemb_Wzi, Capsule assembly protein Wzi. Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation. This family plays a role in group 1 capsule biosynthesis. It is likely to be involved in the later stages of capsule assembly. It is likely to consist of a beta-barrel structure.	1.64723e-126
NC_012918.1\|WP_015837855.1\|3016083_3016341_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	gnl\|CDD\|198034	smart00966, SpoVT_AbrB, SpoVT / AbrB like domain. This domain is found in AbrB from Bacillus subtilis. The product of the abrB gene is an ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. AbrB is thought to interact directly with the transcription initiation regions of genes under its control. AbrB contains a helix-turn-helix structure, but this domain ends before the helix-turn-helix begins. The product of the B. subtilis gene spoVT is another member of this family and is also a transcriptional regulator. DNA-binding activity in this AbrB homologue requires hexamerisation. Another family member has been isolated from the Sulfolobus solfataricus and has been identified as a homologue of bacterial repressor-like proteins. The Escherichia coli family member SohA or Prl1F appears to be bifunctional and is able to regulate its own expression as well as relieve the export block imposed by high-level synthesis of beta-galactosidase hybrid proteins.	3.98326e-06
NC_012918.1\|WP_015837838.1\|2996987_2998358_+\|S41-family-peptidase	gnl\|CDD\|223864	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane].	5.30197e-129
NC_012918.1\|WP_015837840.1\|2999738_3000407_+\|serine-O-acetyltransferase	gnl\|CDD\|200082	TIGR01172, Serine_acetyltransferase, serine O-acetyltransferase. Cysteine biosynthesis [Amino acid biosynthesis, Serine family].	3.92603e-97
NC_012918.1\|WP_015837845.1\|3005610_3006285_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.59133e-05
NC_012918.1\|WP_015837856.1\|3016602_3016833_+\|DUF2281-domain-containing-protein	gnl\|CDD\|378366	pfam10047, DUF2281, Protein of unknown function (DUF2281). Members of this family of hypothetical bacterial proteins have no known function.	0.00109021

>NC_012918.1|WP_015837846.1|3006308_3007184_-|AAA-family-ATPase
MYCEFYGFRESPFTITPNPRFLFLSDHHREALAHLLYAVENRVGFVELTGEVGTGKTTVLRTFLTRLDGRGHRTALIFNPCLSSLELLKSVNREFGLSCDSESRVDLLQVLNEFLLEQKRAGHSVVLVMDEAQNLSPEVLEQIRLISNLETETDKLIQIVLSGQPELLAVLAREELRQLNQRITVRYHLLPMDFENTRRYIDHRMELAGCHRAAEFSVAALKRIFRFSGGIPRLVNVVCDRALLIGFTAESRIISGGMAAQAVSEVAGRAPYGITARVLRRVFGRVPRWLN
>NC_012918.1|WP_015837845.1|3005610_3006285_-|hypothetical-protein
MSSILKALEKVEDAQNQKRNPGAGGLGRKRERRPAWLIPAWSLGGAAVATLVTYSIMGGFGKPAPPAAQVVATAPQPAARPAAPVAEAAVSTAPVATEKPVAAPVKSRQTRDEVKAPVRKQQVGSVPKLAAKPQRSLKVPEPPVSARPAAVHAAPALVAPPQEIRVTGIAWQNDSQSSFAMVNGRPVRQGAVVDGYKVEQIFEDSVRFTGGKGPVTIPLGAAEQ
>NC_012918.1|WP_015837844.1|3005321_3005600_-|YcgN-family-cysteine-cluster-protein
MSGGKSNREQWEGLCEQCGLCCFEKIEDEDGRILFTSTPCRYLDIDTRRCKIYEKRFKIFPECVELTPELVKELKWLHRSCGYKKAMKKGII
>NC_012918.1|WP_015837843.1|3003760_3005020_-|hypothetical-protein
MASVENRQVAAARLSQGDFQALPLDKKGKYLKTAPAREKMELIIADPDAKRVAATLEPQEFFWLVKEVGETDALELLQVASADQCVFILDMEAWEGWTFSEEQVHHWLEKFMEGGEPRVHELLKHLDFDLLQLFLSREIEVGGGIGDQSNDQERLAEYDHTFDGVFMINFKNPKHSQLVGTFLSMLIKLDNSLYTALMEGAKGEVDLELEEQCQRFRTGRLQDLGFPPLDEALSIYARVNPEHFHLEGGKELSPAGEGGQLVPVGADEGTFFSRALALAATPTLYQELNYLVNSALVAEGNAFHEPETMLAILHRVSGYLNIALERLAPADEQRAADILVSEELKRLFQLGYSIVLQLKFSARDVETADYASGKLLAGLKTKRPRFYRGLDPDGVDGYREFRDLSDVQRVADLLAQLKP
>NC_012918.1|WP_015837842.1|3002029_3003250_-|hybrid-sensor-histidine-kinase/response-regulator
MKVLVVDDSRNDRKIIRYNFEWHGCEVLEASNGKQGLELAAAEKPDLIVSDCLMPVMDGFQFLHEIKKFQDTKTIPFIFYSAVYTGSREAELAASLGARAFLAKPMRPEELWDEVGRLMAAEPAGEAVERKPWPEEEFLKNYSQLVAGKLEEKVRELTETNESLLRLNSELERRVVERTSQLEAANRELDMFSYSISHDLRAPLRHLEGFSQALIDEYATKLNHTGREYLERLRKSARRLTDMIDALLELSRHTRGKLVKESVDLTSIAKEVAAQLARSQPERKVSMEVAEGMMVRGDSRLLKVVLEQLIGNAWKFSQPRGEEALVEVFPTELEGRPACAVRDNGVGFEMEYADKLFSPFQRLHAQDEFPGRGIGLAIAKRIITRHGGKMEAQAELGKGATFTFSV
>NC_012918.1|WP_015837841.1|3000743_3002033_+|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB
MSKTIAITTLGCKINQFESAAMTQALEQNGYSMVPFSAKADIYVVNSCTVTAKTDAESRRLIRRATRLNPEARVVVTGCYAQMNGEELLKLAGVNLILGNSEKKDIVGFLEGLDDQPRAVVSDISLEKTGETAPLETFAEHTRAFLQVQNGCDARCAYCIVPFARGASRSVAVQEALDGMAAFAAQGFQEIVLTGIHLGAYGLDLAPPTDLLGLMRKAQDQGAVRRLRIGSVEPTEVSRQLIDFMGTSTIACPHLHLPLQSGSDSVLSRMNRGYDTALFAEVVHSLVSAMPEVCIGSDVIAGFPGESDREFDETYRFIDSLPLAYLHVFPFSQRPGTPAATMTPQVNPKVIKERAEALRVLSERKKSDYAAGFVGRELQVLVQRGEKGLSRNYLTVLVEDSEGLVNREVTVLVTGAKGGELTARVLKES
>NC_012918.1|WP_015837840.1|2999738_3000407_+|serine-O-acetyltransferase
MFSRIKSDIQAVFDRDPAARSVLEVIFCYPGLHAIWFHRISHWFWKHEFWFLGRFTSHIGRFLTGVEIHPGATIGQGFFIDHGMGVVIGETAEIGENVTLYHGVTLGGVSWEKVKRHPTLMDNVVIGSGAKILGPFTVGKDSKVGSNSVVVKEVPPNSTVVGIPGRVVMATEKPQERLDLEHGKMPDPEAKAISCLFDQIRELERKYTALAAEHEALKKKLG
>NC_012918.1|WP_015837839.1|2998354_2999275_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MTTASDLTGRIPNLLVILGATASGKTRLGVQLSGRLNGEIISADSRQVYRGMDIGTGKDLHEYQGIPYHLIDVAPAGHEFNLFQFQRLFLAAFADIRSRGGFPVLVGGSGMYLDCVLRGYRLVEVPEDPALREELAPLSMEELASRLTRSNPRLHNSTDLTERARLVRALEIAEYRGGGSDNWPEIAPFIIGIRWERAQLRERITKRLKERMEQGMVEEVERLHAMGTSWEQLEFYGLEYRYLARYLKGELSRNDMFQKLNSAIHDFAKKQENWFRKMQTNGTAINWVEGAGDPLAQALELLAKNR
>NC_012918.1|WP_015837838.1|2996987_2998358_+|S41-family-peptidase
MSKKVFAAFAVIFLLLSLVLMLPLLDREERAKRSEAEYLEMFREVVNIVKQSYVDKVDDKKLMAGAINGMLATLDPHSTYLPATDYTEMKVHMAGAFGGLGIELEMRNGKLMVNAPIEDTPAFRAGIQSGDHIWTIDGKPTADLNINQCVSRMRGTPGTSVTLGIMREGKPSPLTFRLVRAIIKTKSLKGRLLEPGYGYIRIGEFQERTGEDFEKALKTLAADNGQPLSGLVLDLRFNPGGLVDQAYRVANRFIGEGLSSGVIVTTKGRDPSMERSLTATVGDKEPRYPIVVLINGGSASASEIVAGALQDQKRAVIMGTQSFGKGSVQSVMTLDNGDGLKLTTARYYTPSGRSIQAKGITPDIVVEFAKPAPPAKDKQKGEKELEIREQDLDGHMDQAPAPTRPANPHQAPPPSPSLKPSGKEVKEQDLLKADNQLARALDLLKGVNLLQASGRR
>NC_012918.1|WP_015837837.1|2996184_2996775_-|DUF502-domain-containing-protein
MEKMIRHFKGRFITGLFVVVPLGITIFILKFLFNFADGILGSYLDSLLSAFLDNPYHIPGLGMLTGAIVIYVSGVLATNVIGTRIIRWWDKLLCRIPVVKSIYGSSKQLTQVFKEGKSSYRRAVFVEWPRPGVRAVGFVTAEVEREGEKLVVVYVPTMPNPTSGFALFFKEAEVRDCGMSVEDAVKFVVSGGAVVQ
>NC_012918.1|WP_015837848.1|3008259_3008547_-|hypothetical-protein
MKKDNLEVILEQMNSKFDLVLEGHAVLRSEIRELSRKTDERFDMVDFKIETLNKKIDAVDEKLSKRLDAVAADLSAHRADTEAHHGVYRVMESDS
>NC_012918.1|WP_015837849.1|3008751_3009006_-|hypothetical-protein
MKKENLEVILEQMNSKFDLVFEGHAVLRNEIREVSRKADERFDLVDFKIETLNKKIDAVAADLSAHRADTEAHHGVYRVMESDS
>NC_012918.1|WP_157506155.1|3009210_3010623_-|capsule-assembly-Wzi-family-protein
MRATALMSLCFLLLLSTVAFADSYLPLDSRLYGDLRFLEANGGITTAQLSTLPISRREAARLTSEAIENVAADDSFRVQAALARLKQEFRRELEGDTSAEFVMDTADLQYMYSDDKGFFWQKNRDGVEVRRGHNLFLNATGRFDSKYLGAVVRPEADLYEGDAGLRLKKAYLLANLGREEFVVGKESQWWGTGLNGSPLLSDNAEPLTVFKISNSVPYFPFGIGVRGSFFVTRLEEERTDVDRPILYGMRLDLKPSPWFELGLAKTALLGGEGRNAGLSTFGNSLLALGENEEGEAGDQRAGLDAKVVIPWRVQPITLSVEMTGEDQRNNFPEKWFEVYGIYLPRVLSLERLEVLAEYATNVDGYYKGVWYTHHIYTQGYTYHGRIIGHYIGSDARDLFVRAQYHFDPLILSLSYENLHKVYPESIRWESFEASALTELSHHTDLTVSAGYAREAEKNFIMRMGLRHYFM
>NC_012918.1|WP_015837851.1|3010860_3012492_-|capsule-assembly-Wzi-family-protein
MRFFLVALVVCITSFASSAFALSSANIPLDSPIYLYLEKLSGYGLVSGDVKGIRPFSKAEAVRLLREAETHLASGDHPRLAGEIVQRLRELLPREVALYGDEAKANPLDFEPVAAARLRYVHLDGKPRSYFRAVHDAGHDGVFGIGSGLRPATPYPHPIQQRGYEGTPLFENNDGVVYRSGSNLDLRASGEAYWGSKAALLIEPMLLWSEETDEATLRLNRGYVKFGGKGLELEAGRDENWLGPGYRGAITLTNNARNMDLVKLSSPELVSSKYLWDLKYTLIFSQLEKTVTDGQEREPFFFAGKLSMKPMRNIEFGINLGRQVGGPGVSNSLGDNARGMIGGWNQDNSNTVAGVDLRFRLPWLRNSELYGEFSGEDAAAFWPIVESYVAGFFIPSLTESGRDDLRFEYFRGNEILYSNGTFPAGYLYHGLPIGHSQGGAAEEWFLRYSHWFSVRNNLAVEATHGTRGGYGRMTVDATGAFDPAGVMQAVERRDALRAFWSFPVQGEWSALVMYGHEWINNLELRQGESRKNQLLRVELTYRY
>NC_012918.1|WP_015837852.1|3012555_3012933_-|GxxExxY-protein
MTENEIATVIVDASFKVHKHLGPGLLESVYLAVLAYELEQRDVMVSRQQPMPIIYESVRLDEAYRADLVVNDKVIVELKSVEKIAPVHKKQLLTYLRLSNLKLGLLINFGEALIKDGITRVVNDL
>NC_012918.1|WP_015837853.1|3013069_3015013_-|polysaccharide-biosynthesis-protein
MFRTRRILVFFLDVALIVAAFVLAFLLRFDFQIPADQSSALLQGLLIILVAKPVIFIASGMYRCIWRYASLQDAYEIFKAVTLSSVVSAFTFLFMKGPFALPRSIYFLDWFLLFSMVACSRLLWRVYRETKFLPSLHKGKKTLIIGAGEAGNLLLKEIRKEADSPYNVIGFVDDDIEKRGMRLSGVRVLGGTSRLCALVRKHAIEEVIFAIPSGDRELMRRVIANCERGKARFKTLPGITAIVDGKVSMSQIKDVEIEDLLGRDPVLLDQTAIRNYLTDKRVLVTGAAGSIGSEICRQVARFKPAKLVLFDHAETPLFYIEKELAASFPDLRLIPMVGDVKNQERVEAVFDEFCPEVVFHAAAYKHVAMMEYNPAEAVLNNVLGSRIVADAAHKTKVRNFVMVSTDKAVNPTNVMGATKRSAEIYVQALAAKSQTKFTTVRFGNVLGSNGSVIPLFKEQIKNGGPVTVTHSDVVRYFMTIPEASQLVMQAGCIGRGGEIFVLDMGDPVRILSLAEELIRLSGLVPYKEMDIQFTGLKPGEKLFEELLINGEGIKPTSHKKIRVMAPVETDLRRVSQDFDEMFAHARNQDIGELLKALRRIVPEFVPRYEFDVAPPMAFQRVRPDLFPPQKLTLVRNLQLASKEGSAA
>NC_012918.1|WP_015837854.1|3015685_3016090_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MVKRPVETVARKRQWVPDRQDVIWINCSPHAGTEMKDLHPLLVLSPAIFNERTSLVIGLPMTTAEYNADNPFAVAIGTARGRKSGKTSYVLCHQPKSFDWRIRSGAPHPLKRLSDAHFAQCCARLNQIIQINPA
>NC_012918.1|WP_015837855.1|3016083_3016341_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein
MRQAEAVLDLKQWGNNLGVRLPMRVARAAHLHLNQKVLVAVEDGRVVITPVEEIAPTLEQRLLLFDPVKHGGEVMAAEPVGAEKW
>NC_012918.1|WP_015837856.1|3016602_3016833_+|DUF2281-domain-containing-protein
MATASIKKEIITHVERLPSSLQRQVLEFTRALERKQLKGTHGKSLLPFAGTIALIDLETMTQAIDEGCERLNISSR
>NC_012918.1|WP_015837857.1|3017275_3017953_+|hypothetical-protein
MAALPDLFDLNLNGYSINDFIAEVNIIADQTEKHSALKDFPEYFTPAEKLREKAAQLVQLRDASANGDRGKKAEKLAVWEETKLALIMNAQHITMLSLHRNDPSILLNTGYKLKQKHSGKPTSASSTDLLAETPGLSLKYMQSGSGPLPSSFTVHITRAKNKASTELQMSDNPSDESSWNSQGIYAKARIDYKGQQSEKRLYFRARYHHDGGVGPWSQVVNILVL

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Crispr_ID: NC_012918_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012918_10

3043901-3044034

Orphan

Consensus_repeat	Method
AGGTTCCGCAGTATCCCCTGCATCCGCCGTTATCCCTGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012918_10

>merge|NC_012918|10|3043901-3044034|CRISPRCasFinder
AGGTTCCGCAGTATCCCCTGCATCCGCCGTTATCCCTGTTCAACGATTTAGCCTTTCTTTGCGTCTTTGCGGCTTGGCGTGAACGGGTTGCTTCAGGTTCCGCAGTATCCCCTGCATCCGCCGTTATCCCTGTT

>NC_012918|10|10|3043901-3044034|CRISPRCasFinder
AGGTTCCGCAGTATCCCCTGCATCCGCCGTTATCCCTGTT	CAACGATTTAGCCTTTCTTTGCGTCTTTGCGGCTTGGCGTGAACGGGTTGCTTC
AGGTTCCGCAGTATCCCCTGCATCCGCCGTTATCCCTGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_012918.1\|WP_015837886.1\|3054550_3055048_-\|chemotaxis-protein-CheD	unknown	unknown	gnl\|CDD\|319352
NC_012918.1\|WP_015837880.1\|3047540_3047825_-\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|376187
NC_012918.1\|WP_157506223.1\|3046098_3046392_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015837884.1\|3052159_3053395_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|225968
NC_012918.1\|WP_157506156.1\|3032992_3034399_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235373
NC_012918.1\|WP_015837872.1\|3034398_3035745_-\|flippase	unknown	unknown	gnl\|CDD\|240533
NC_012918.1\|WP_015837869.1\|3031114_3031843_-\|formyl-transferase	unknown	unknown	gnl\|CDD\|187712
NC_012918.1\|WP_015837885.1\|3053479_3054550_-\|chemotaxis-response-regulator-protein-glutamate-methylesterase	unknown	unknown	gnl\|CDD\|234828
NC_012918.1\|WP_015837881.1\|3048198_3049020_-\|3-deoxy-8-phosphooctulonate-synthase	unknown	unknown	gnl\|CDD\|235363
NC_012918.1\|WP_015837875.1\|3039091_3041902_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224512
NC_012918.1\|WP_015837882.1\|3049258_3050860_-\|CTP-synthase	unknown	unknown	gnl\|CDD\|235437
NC_012918.1\|WP_015837876.1\|3043090_3043606_-\|HAD-IIIA-family-hydrolase	unknown	unknown	gnl\|CDD\|224692
NC_012918.1\|WP_015837883.1\|3051204_3051963_-\|3-deoxy-manno-octulosonate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|133010
NC_012918.1\|WP_157506158.1\|3047097_3047571_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_157506157.1\|3035898_3036198_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|187550
NC_012918.1\|WP_015837868.1\|3029865_3031122_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340838
NC_012918.1\|WP_015837877.1\|3044238_3045207_-\|KpsF/GutQ-family-sugar-phosphate-isomerase	unknown	unknown	gnl\|CDD\|182814
NC_012918.1\|WP_015837867.1\|3028444_3029407_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133055
NC_012918.1\|WP_015837870.1\|3031839_3032928_-\|DegT/DnrJ/EryC1/StrS-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|99740
NC_012918.1\|WP_015837873.1\|3036388_3037507_-\|GDP-mannose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|224014

Protein	Function_ID	Function_description	E-value
NC_012918.1\|WP_015837886.1\|3054550_3055048_-\|chemotaxis-protein-CheD	gnl\|CDD\|319352	cd16352, CheD, chemotaxis protein CheD stimulates methylation of methyl-accepting chemotaxis proteins. This family contains bacterial chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs). The CheD chemotaxis gene is not found in the Escherichia coli genome, but is present in many other organisms, including B. subtilis, where CheD appears to have two separate roles; it binds to chemoreceptors to activate them as part of the CheC/CheD/CheYp adaptation system, and it deamidates selected residues to activate chemoreceptors, enabling them to mediate amino acid chemotaxis. CheD has been shown to catalyze amide hydrolysis of specific glutaminyl side chains of the B. subtilis chemoreceptors McpA, McpB and McpC; deamination by CheD is required for the chemoreceptors to effectively transduce signals to the CheA kinase. CheD's ability to bind the receptors is controlled by CheC via a competitive binding mechanism; substituting Gln into the receptor motif of the signal-terminating phosphatase, CheC, turns the inhibitor into a receptor-modifying deamidase CheD substrate. Also, CheYp increases the affinity of CheD for CheC, controlling CheD binding to the receptors through its interactions with CheC. Thus, high levels of CheYp means CheC is a better binding target for CheD than the receptors, resulting in decreased CheA activity. The CheD structure reveals a distant homology with a class of bacterial toxins represented by the cytotoxic necrotizing factor 1 (CNF1) as well as a class of proteins of unknown function represented by B. subtilis YfiH. An invariant Cys-His pair forming a catalytic dyad is observed, and is required by the toxins for deamidation activity.	2.22679e-52
NC_012918.1\|WP_015837885.1\|3053479_3054550_-\|chemotaxis-response-regulator-protein-glutamate-methylesterase	gnl\|CDD\|234828	PRK00742, PRK00742, chemotaxis-specific protein-glutamate methyltransferase CheB.	4.35792e-176
NC_012918.1\|WP_015837884.1\|3052159_3053395_-\|EAL-domain-containing-protein	gnl\|CDD\|225968	COG3434, COG3434, Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms].	2.13551e-86
NC_012918.1\|WP_157506156.1\|3032992_3034399_-\|hypothetical-protein	gnl\|CDD\|235373	PRK05249, PRK05249, Si-specific NAD(P)(+) transhydrogenase.	0.00764549
NC_012918.1\|WP_015837872.1\|3034398_3035745_-\|flippase	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	2.48014e-76
NC_012918.1\|WP_015837869.1\|3031114_3031843_-\|formyl-transferase	gnl\|CDD\|187712	cd08369, FMT_core, Formyltransferase, catalytic core domain. Formyltransferase, catalytic core domain. The proteins of this superfamily contain a formyltransferase domain that hydrolyzes the removal of a formyl group from its substrate as part of a multistep transfer mechanism, and this alignment model represents the catalytic core of the formyltransferase domain. This family includes the following known members; Glycinamide Ribonucleotide Transformylase (GART), Formyl-FH4 Hydrolase, Methionyl-tRNA Formyltransferase, ArnA, and 10-Formyltetrahydrofolate Dehydrogenase (FDH). Glycinamide Ribonucleotide Transformylase (GART) catalyzes the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. Formyl-FH4 Hydrolase catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to FH4 and formate. Methionyl-tRNA Formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA, which plays important role in translation initiation. ArnA is required for the modification of lipid A with 4-amino-4-deoxy-l-arabinose (Ara4N) that leads to resistance to cationic antimicrobial peptides (CAMPs) and clinical antimicrobials such as polymyxin. 10-formyltetrahydrofolate dehydrogenase (FDH) catalyzes the conversion of 10-formyltetrahydrofolate, a precursor for nucleotide biosynthesis, to tetrahydrofolate. Members of this family are multidomain proteins. The formyltransferase domain is located at the N-terminus of FDH, Methionyl-tRNA Formyltransferase and ArnA, and at the C-terminus of Formyl-FH4 Hydrolase. Prokaryotic Glycinamide Ribonucleotide Transformylase (GART) is a single domain protein while eukaryotic GART is a trifunctional protein that catalyzes the second, third and fifth steps in de novo purine biosynthesis.	2.13198e-46
NC_012918.1\|WP_015837881.1\|3048198_3049020_-\|3-deoxy-8-phosphooctulonate-synthase	gnl\|CDD\|235363	PRK05198, PRK05198, 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional.	0
NC_012918.1\|WP_015837875.1\|3039091_3041902_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224512	COG1596, Wza, Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis].	2.83706e-26
NC_012918.1\|WP_015837882.1\|3049258_3050860_-\|CTP-synthase	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NC_012918.1\|WP_015837876.1\|3043090_3043606_-\|HAD-IIIA-family-hydrolase	gnl\|CDD\|224692	COG1778, COG1778, Low specificity phosphatase (HAD superfamily) [General function prediction only].	9.91324e-76
NC_012918.1\|WP_015837883.1\|3051204_3051963_-\|3-deoxy-manno-octulosonate-cytidylyltransferase	gnl\|CDD\|133010	cd02517, CMP-KDO-Synthetase, CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide. CMP-KDO Synthetase: 3-Deoxy-D-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) catalyzes the conversion of CTP and 3-deoxy-D-manno-octulosonate into CMP-3-deoxy-D-manno-octulosonate (CMP-KDO) and pyrophosphate. KDO is an essential component of the lipopolysaccharide found in the outer surface of gram-negative eubacteria. It is also a constituent of the capsular polysaccharides of some gram-negative eubacteria. Its presence in the cell wall polysaccharides of green algae and plant were also discovered. However, they have not been found in yeast and animals. The absence of the enzyme in mammalian cells makes it an attractive target molecule for drug design.	1.68655e-140
NC_012918.1\|WP_015837880.1\|3047540_3047825_-\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|376187	pfam18765, Polbeta, Polymerase beta, Nucleotidyltransferase. A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.	4.01554e-07
NC_012918.1\|WP_157506157.1\|3035898_3036198_-\|hypothetical-protein	gnl\|CDD\|187550	cd05239, GDP_FS_SDR_e, GDP-fucose synthetase, extended (e) SDRs. GDP-fucose synthetase (aka 3, 5-epimerase-4-reductase) acts in the NADP-dependent synthesis of GDP-fucose from GDP-mannose. Two activities have been proposed for the same active site: epimerization and reduction. Proteins in this subgroup are extended SDRs, which have a characteristic active site tetrad and an NADP-binding motif, [AT]GXXGXXG, that is a close match to the archetypical form. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.60964e-30
NC_012918.1\|WP_015837868.1\|3029865_3031122_-\|glycosyltransferase	gnl\|CDD\|340838	cd03809, GT4_MtfB-like, glycosyltransferases MtfB, WbpX, and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.	3.22448e-41
NC_012918.1\|WP_015837877.1\|3044238_3045207_-\|KpsF/GutQ-family-sugar-phosphate-isomerase	gnl\|CDD\|182814	PRK10892, PRK10892, arabinose-5-phosphate isomerase KdsD.	1.77212e-129
NC_012918.1\|WP_015837867.1\|3028444_3029407_-\|glycosyltransferase	gnl\|CDD\|133055	cd06433, GT_2_WfgS_like, WfgS and WfeV are involved in O-antigen biosynthesis. Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	4.0269e-69
NC_012918.1\|WP_015837870.1\|3031839_3032928_-\|DegT/DnrJ/EryC1/StrS-aminotransferase-family-protein	gnl\|CDD\|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	1.18342e-170
NC_012918.1\|WP_015837873.1\|3036388_3037507_-\|GDP-mannose-4,6-dehydratase	gnl\|CDD\|224014	COG1089, Gmd, GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane].	0

>NC_012918.1|WP_015837876.1|3043090_3043606_-|HAD-IIIA-family-hydrolase
MEERLKKIKLLILDVDGVMTDGRIIFDSNGVESKFFNVKDGHGIKMLQRSGIEVGIISGRESQVVYNRAVELGIGQVYQKSLDKLVPYRQMLEATGLTDEQVAFMGDDVIDIPLLKRVGFAAAPADAVDEVIPFAQFVAKNKGGWGAVREVCDLILKAQGNWETVTSRYYV
>NC_012918.1|WP_015837875.1|3039091_3041902_-|polysaccharide-biosynthesis-protein
MKRIPLLAVALYLLTAVTSYSASLYDGSSSTSTSYAGTSATTTQVTAPTSSSYFTIPAPTGQGSGSSYYQYPNQPQTAGQTQPLGAPQQTQVLQQGQVPMQGQVLMQGQVPMQGQVPMQGQVPMQGQVPQQGQVPQQGQAEAQRFGQQGQNSNQTASTPYQQSSQVPQPGQEWGKQPLPQAWQQWVPPAEPSALEKAMGADPVTAESSLSQAYGVGPLTQFGYSFFHPEVSDPLSTQMDIPVGPDYILGPGDRLLVTLWGSIDGTWELEVSRSGEIVLPKVGSVKVAGQSFGQVPSLLKNTLARIFKDFQLNVNMGRLRVIKVYVVGEVTSPGDYNISSLSTLVNALAAAGGPTKSGSLRNIKINRNGKVVETVDLYDFFLNGDKGKDIRLQPGDTVLVPVIGQVAGIAGNVRRPGIYELKGESTLKDLLALCGGIDSTAYLQRLQMYRVQAHDKKMVTEIAFEPGKNVEDATAGIKLQDLDLVKVLSIDTVLRGYVRLEGHVLRPGDYALKPGMRVSALLRGDNLLPEYHGVAGQITRLFQPDLHPEIVYFNVNGALNGEPEQDLELKEFDRVRIFSKLEMEEIPLVQVSGEVLRPGQYRYLENMTVRDLLMQAGNVRLSAYMKNAEVVRLRRLDSGVVTYVIPVDLEAALKGGEENIKLQPFDELTVRRIPNWAEATDRYVTLNGEFVFPGTYPIHKGERLSSVIVRAGGFSPLAYIKGARFTRESVRNLQQQRMDEALQKAQEDIINLQTNMAQTAASAEEVAAAKTTLDGLSRSVEILKTKKAEGRMLMEIASLDELKGGAYDLELQGGDQLIVPSDPGGVNVIGNVYNQSSVVSQQGRDVDWYLQQVGGPTGEADTSEIYVVKVNGSVVSQANSANFMFYNSFWGKELNSGDTIIVPRQYEKTAWLRYIKEITQILGNVAMTAGVVIAAGK
>NC_012918.1|WP_015837873.1|3036388_3037507_-|GDP-mannose-4,6-dehydratase
MKKAIITGITGQDGSYLAELLLEKGYEVHGIKRRASSFNTQRVDHIYQDPHIKDAHFKLHYGDLTDSSNLTRIMQEVQPDEVYNLGAQSHVAVSFESPEYTVETDGVGTLRILEAVRLLGLDKKTRFYQASTSELYGLVQETPQKETTPFYPRSPYAVAKLYAYWITVNYREAYGMYACNGILFNHESPRRGETFVTRKITRGLANIAQGLEQCLYMGNIDSLRDWGHAKDYVKMQWLMLQQDKPEDFVIATGVQYTVRQFIIWTAAELGVTLQFEGDGVDEIATVISVEGTKAPALKVGDIVVRIDPRYFRPSEVETLLGDPTKAKQKLGWFPETTVQEMCAEMVAHDLEEAKRHALLKSHGFSVAVCTEH
>NC_012918.1|WP_157506157.1|3035898_3036198_-|hypothetical-protein
MYLMMLPPDEYGFFLNDATPPLINIGTGEDITIAELAKTICTVVGYTGTIVFDASKPDGTMQKLLDVSLLNSRGWKATTGLEEGLRVAYRSFLEQQKGC
>NC_012918.1|WP_015837872.1|3034398_3035745_-|flippase
MNATWLKYLPRFIRAKLDGRLGLQAIMSNTGWLVADKVLRMVVGLSAGVWVARYLGPEQFGLFNYALAFVAIFSGVASLGLNGVVVRDLVRQFENTNATLGTAFLLQFLGGLLSLAFAVIAINIIRPDDLLVRNMVVVLGVVMVFKSTEVIKYWFESKVQSRYTVWVENSAFLLFVAVKISLILADAPLMGFAWTYCAEGMLVAIGLTLVYISRGGQLSAWRLYYPCARSLLKDSWPLLLSGTLVLVNMSIDKIMLGQLSNERDVGLYSVANAFVSFWYFIPVAIIGSVAPKLIKTHTADLVGYDNLAKKIYKYFGGGAVIVAVIISLFANHLVAFLYGANFKEAGAILAVSIWAIVFVFQVSFRGRLLVIEGEQVYITLLIFLGTLSNIVLNVLLIPSNGAIGAAIAYTLSWGMSAVIFPVIFKKTRHHAMWSLGLNWEVNSCLRGK
>NC_012918.1|WP_157506156.1|3032992_3034399_-|hypothetical-protein
MATYQKSKLSLVDDVGVLHISDKKILRAIHENAVTAANKLLASGLLDELIEKGLFPKTSISSVVISGHSLVLEHERIDPVIYPFEWSPEMLRHAALCVLQINECANKYGYELKDAHPYNVVFRLNKPVYVDFGSFAKLQTPGAWVAYNEFLISFYYPLLLCAKRLIRLYKHMYLIGGVTIGRAELVSIVNPIFRILGVRVTVRMLAFLDAYMRGPTIADDKINSRFKQPIFNLIVKFLLKSKFLPYRKDLTKTIATKIESMNLRNQSMWADYHQLAGFYSDNGSIKLSPRMSWITEVVSELKPKTIIELAGNQGILSRTLSKINGVEKVICTDYDENSIDALLLQLKRDENVTMACFNFMGEAWQLFSNERSNRLKSEMVIALAVTHHLILTQQYNIDCILRTLTSYSCKYVIVEFMPLGLWDGVSAPPLPSWYNEQWFVDNLRNHCEILQRQELEPNRVVFVTRIKS
>NC_012918.1|WP_015837870.1|3031839_3032928_-|DegT/DnrJ/EryC1/StrS-aminotransferase-family-protein
MKIPVYQPSLSGNEKKYVNECLDSTWISSKGKFVNKFESSLASYTGVKHATSVCNGTVALHLALVALGIGPGDEVIVPTLTYIASVNAIVYTGAVPIFVDSLPDTWQMDPEDVSRKITSHTKAVMAVHLYGHPCDMDRIMTVASEHGLFVIEDCAEAFGTLYKGKPVGSFGDIATYSFFGNKTITCGEGGMLVTNDETLFDRALHFKGQGLAKHREYWHDVIGYNYRMTNICAAIGLAQLEQADGFIRKKRQIAEWYKEGLQGLPVTVHGEVGDVRHSYWMVSILVEKPDQRDSLRDALATAGVETRPLFYPVHTMPMYASKFQRHPVAENLGWRGINLPSWPGLDELTVAKIVGIHKEYFR
>NC_012918.1|WP_015837869.1|3031114_3031843_-|formyl-transferase
MNIILCGYHWTGCKALDLLDKQGHNIFVFTHESPYYVPSLSALCIDRNIPFSYENISKAKLPFVPDVICSVYYRYIISTKVISCCDGKIFNLHPSILPKYRGCSSVTWAIINNEQETGFSYHYIDSGCDTGNIILQKPIKIENWDTQLSLFNRVMFHSMLFFDKALEMVVSGFEGIQQTGDSSFYKRGCPYNGVINGNWEIAYIERFIRAMYNPPYPPAIFNGKEIRTLEDYLSVGSIKTND
>NC_012918.1|WP_015837868.1|3029865_3031122_-|glycosyltransferase
MINNKTVIALLGNSFIGWGGGIDFLRFCANALALICKGNNTRIVILLPDPENCTLIIKTRAFLSACKQIAIAILERRKPISRRHKPFFKKQLTDSFQNIEGNVEILFYPQGKNIASVVVSIQADVVIPCAFSLGSSFPVPWVGYLYDFQHKYFPDYFSDKEINTRDALFSQMLGEASAVIVNAADVKKDIQKFYPQTKCKVFDLPFSATPIESWFEPASEDLSQKYDLPRIYFVMCNQFWIHKDHATAFKALAIYMEATGQQDVHIVCTGSTVDFRHPDYFSNLKNYVNTLGLTDRVHFLGHIPKKDQIDIMCGSIAVLQPTLFEGGPGGFAVFDAISLAIPVILSDIPVNREIEGYNGLLFFKAGDADDMAAKMIAIQNFTHVKQGKELLLTTGRERTKTFGLRLLEAAEYAMNQQN
>NC_012918.1|WP_015837867.1|3028444_3029407_-|glycosyltransferase
MTSADQTTTLISLDPAYSTTRLVTQVNPGYNIVPDAKFDTVVSECESRRGEGGLRTKGYFKQSFICKPLVTVITVVFNGQKHIEETIQSVICQTYDNVEYIIIDGGSTDGTVDLIRKYREQIDYWVSEDDEGIYDAMNKGIKLAQGTWIALLNSDDYYVDKDALYTLSEVGEIYDVAVSDVIILTAHSKKLFAVDYRRPSYLNIPYMHTGMFFRKKAYYEAGYYDIRYKIASDIEYVFRHKSLGSNIIKLSLPLVCMRDDGASSRMFKIGRREYRQIYIKYGGSLLLGWYGYFYSRTEKWAYNSLVIREGWRILKRILAK
>NC_012918.1|WP_015837877.1|3044238_3045207_-|KpsF/GutQ-family-sugar-phosphate-isomerase
MIIEEAKRVIRVEAEALLNLEASINGAFEQAVRMILNSETGRVVVTGMGKSGLIGQKIASTMASTGTPAFFLHPAEGIHGDLGMIMKGDVVIAISNSGETDEVVKILPIIKRLGASLIAMAGNPASTLAKSGDIFLDISVKEEACPLGLAPTASTTVTLAMGDAIAVALLVSRGFKAEDFAMFHPGGALGRRLLLRVQDIMHSGEALPLVNEKTLMREALFTITSKGLGITGVTSDDGALIGVITDGDLRRALGKGLDIINLPAAELMKAGAKRIRRDELAARALQQMEQYSITSLFVFDDDKAKAPVGIVHLHDLLKAGIA
>NC_012918.1|WP_157506223.1|3046098_3046392_-|hypothetical-protein
MSVSFGSKLEQLSSGFDSKLEQQKEEILKEFDHQTTIQTEQFHKAIGIVVEGHQMLAEKIDRVELRLESKIDSIAQQLDAHRSDIKAHGGAYRVMEE
>NC_012918.1|WP_157506158.1|3047097_3047571_-|hypothetical-protein
MGIEDRGEALTGQLQLILQKELKLLADATEVLAYSYNKCSRIGIKSCYEPEELESFESFTGRFARLSDILVQKVFRLIDELDLDTQGTIRDRINRAEKKELIGSSDTFVEIRMIRNDIAHEYVPEAIQEIFVKVLGLTPALLDAVERVKRYCHKYKP
>NC_012918.1|WP_015837880.1|3047540_3047825_-|nucleotidyltransferase-domain-containing-protein
MRLKHDEIQAIKSTIHNLDQDAAVFLFGSRVDDSKKGGDIDLLVLSRRLSGGDVKRAIKAELYRIIGEQKIDILLAADDSDPFVKLALKTGVKL
>NC_012918.1|WP_015837881.1|3048198_3049020_-|3-deoxy-8-phosphooctulonate-synthase
MTREITVGGVKIGGGRPLALVAGPCVIENETATLRCAERLMSICNGVGISLIFKASYDKANRTSVTAFRGPGMKEGLRILAKVKEALGVPVLSDIHSIEQVEPAADVLDVLQIPAFLCRQTDLLVAAANTGKVINVKKGQFLAPWDMKNVVGKISSCGNENIILTERGASFGYNNLVVDMRSFPIMRSTGYPVIFDATHSVQLPGGEGTSSGGQREYVEFLSRAAVAAGVDGIFMEVHEEPEQALCDGPNSVRLDDMPALLKKLKSIDAIVNQ
>NC_012918.1|WP_015837882.1|3049258_3050860_-|CTP-synthase
MKTKFIFVTGGVVSSIGKGLAAASLGALLEARGLRVTIQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERYTSGKLSKKSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHITDQIKLNILENAKGSDIAIVEIGGTVGDIESLPFLEAIRQLKSDRGAGNVLYLHVTLVPYIKTAGELKTKPTQHSVKELREIGIQPDILLCRCEQDVPQDMKAKIALFCNVEEKAVITSQDAEHIYAVPIALNQQGLDDQVVEKLNIWTKAPDLSHWQQVVSKLTNPGSGEVRIAVVGKYVDLKESYKSLSEALTHGGIANDCRVKLVYLDSEKIEEEGIGKSLADVDGILVPGGFGERGTEGKIKAIEYARVNKVPFFGICLGMQMAAVEYARNVCRLPEAFSSEFKPDCESPVIHLMEEQKGVENKGGTMRLGAYPCSLTKGTFAQKAYGATEISERHRHRYEFNNLFRTCLEEKGMVISGVYKEGNLVEIIELPDHPWFLGCQFHPEFKSKPLNPHPLFKAFIGATKAKRG
>NC_012918.1|WP_015837883.1|3051204_3051963_-|3-deoxy-manno-octulosonate-cytidylyltransferase
MKITAVIPARYASTRFEGKALADIMGRPMVQHVYERAAKATLVSEVIVATDDERIAAAVRAFGGRVEMTSPTHETGTDRLAEVAAKIDADIVVNVQGDEPLIDPAMIDEAIRPLLDDPSIPMATLKCRIKTLHDFLSPNVVKVVSDPTGNVLYFSRSPLPFFRDKWNDLKDDAFVSGKLLCYKHVGLYVYRREFLPVFAGLKPTYLELAEKLEQLRVLENGYRIKIVETEFESIGVDTPADLDKVLERLKDR
>NC_012918.1|WP_015837884.1|3052159_3053395_-|EAL-domain-containing-protein
MSEEKFFLGRQPILDRTQKIVGFELLFRSAESLLSANFLDVQMASASVIVGALTEFGIQDVLGRHRGFFNVTREMLMSDAVELLPKDRVVIELLETIAVDREVVDRCRTLKSLGFTLALDDHVYSVDSHEIYEAIDIVKVDVLETPAAALPEMLERLSPWPFTLLAEKVETAEQYRFCSQLGFHLFQGYYFARPVVLRQNKVDIAKIAMLQLMKQVMADTELEEIEETFKQNPGLTYNLLRLVNSVAIGLRVRIKTLRHALMVLGMEQLKRWITLALYASNDSNGVHSPLLEMAATRGKLMELLVLALKGRAGRELADQAFMVGILSLIDVLFDDSMNELVGKLNLVENVKLALLSRQGELGGLLLLAQRLEEADFEGVNEQLEESGLDLDQLLSCQLETIAWSDSLSASL
>NC_012918.1|WP_015837885.1|3053479_3054550_-|chemotaxis-response-regulator-protein-glutamate-methylesterase
MAKKKIKVLIVDDSAVVRQTLSEILSSDPQIEVMSTAGDPFIAADRIRHEVPDVITLDVEMPRMDGITFLHKIMSQHPIPVVMCSSLTEMGSETALKALEYGAVEIIQKPRLGTKTFLEESRVRICDVVKAASQARVRKVSAAPHQVSPKLTADVIMEKPKSQAMMQTTEKVVVIGASTGGTEALRTFLESLPADSPGIVIVQHMPEGFTRAFSQRLDGLCRITVKEAENNDTVVRGRALIAAGNHHLLLKRSGARYYVEIKDGPLVSRHRPSVDVLFRSAARYAGKNAVGVIMTGMGDDGAHGMLEMKQAGAVNIAQDEASCIVFGMPNEAIKLGGVDLVRPLDAISREVLRLCA
>NC_012918.1|WP_015837886.1|3054550_3055048_-|chemotaxis-protein-CheD
MIQHVQSLVFLKPGQMMVSPVPTLVTTLLGSCIAVTLFCPRTRFGAICHAQLPSIGNPAGCSHDDLSHARYVECAVMMMLERLQAHGVANKELQAKVFGGADMFEGNVKRPGVGKQNAEMALKVLDREAVRVLCRDLGGERGRKIVFHTDTGEVLLKRLGKSGVS

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Crispr_ID: NC_012918_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012918_11

3542106-3542177

Orphan

Consensus_repeat	Method
GGACTGCTGCCCCTCCTCACCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012918_11

>merge|NC_012918|11|3542106-3542177|CRISPRCasFinder
GGACTGCTGCCCCTCCTCACCCTACCCCTCTCCCACAGGGCGAGGGGTAGGACTGCTGCCCCTGCTCACCCT

>NC_012918|11|11|3542106-3542177|CRISPRCasFinder
GGACTGCTGCCCCTCCTCACCCT	ACCCCTCTCCCACAGGGCGAGGGGTA
GGACTGCTGCCCCTGCTCACCCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_012918.1\|WP_015838308.1\|3552237_3553704_-\|glucose-dehydrogenase	unknown	unknown	gnl\|CDD\|225044
NC_012918.1\|WP_015838293.1\|3536970_3537132_+\|cbb3-type-cytochrome-oxidase-assembly-protein-CcoS	unknown	unknown	gnl\|CDD\|377073
NC_012918.1\|WP_015838297.1\|3540760_3541318_-\|formylmethanofuran-dehydrogenase-subunit-E	unknown	unknown	gnl\|CDD\|376887
NC_012918.1\|WP_015838296.1\|3540030_3540648_-\|LysE-family-transporter	unknown	unknown	gnl\|CDD\|224199
NC_012918.1\|WP_015838300.1\|3544634_3545342_-\|GspB-domain-containing-protein	unknown	unknown	gnl\|CDD\|339769
NC_012918.1\|WP_015838307.1\|3551871_3552228_-\|cytochrome-c	unknown	unknown	gnl\|CDD\|379187
NC_012918.1\|WP_015838301.1\|3545342_3546953_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|132060
NC_012918.1\|WP_015838291.1\|3534102_3534561_+\|nitrogen-fixation-protein-FixH	unknown	unknown	gnl\|CDD\|377555
NC_012918.1\|WP_015838292.1\|3534557_3536978_+\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|225127
NC_012918.1\|WP_015838304.1\|3548422_3548917_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015838302.1\|3547093_3547711_-\|CAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|349398
NC_012918.1\|WP_015838303.1\|3547707_3547986_-\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015838299.1\|3542353_3544534_-\|ATP-dependent-RecD-like-DNA-helicase	unknown	unknown	gnl\|CDD\|273632
NC_012918.1\|WP_015838306.1\|3550449_3551709_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225971
NC_012918.1\|WP_015838294.1\|3537601_3538261_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|372587
NC_012918.1\|WP_015838298.1\|3541314_3542013_-\|amino-acid-racemase	unknown	unknown	gnl\|CDD\|224707
NC_012918.1\|WP_049760130.1\|3548989_3550285_-\|nodulation-protein-NfeD	unknown	unknown	gnl\|CDD\|223961
NC_012918.1\|WP_015838295.1\|3538722_3540021_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|319871
NC_012918.1\|WP_157506169.1\|3538156_3538687_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|236577
NC_012918.1\|WP_015838290.1\|3532862_3534086_+\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|274278

Protein	Function_ID	Function_description	E-value
NC_012918.1\|WP_015838308.1\|3552237_3553704_-\|glucose-dehydrogenase	gnl\|CDD\|225044	COG2133, COG2133, Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism].	5.76576e-10
NC_012918.1\|WP_015838293.1\|3536970_3537132_+\|cbb3-type-cytochrome-oxidase-assembly-protein-CcoS	gnl\|CDD\|377073	pfam03597, FixS, Cytochrome oxidase maturation protein cbb3-type.	9.37231e-15
NC_012918.1\|WP_015838297.1\|3540760_3541318_-\|formylmethanofuran-dehydrogenase-subunit-E	gnl\|CDD\|376887	pfam02663, FmdE, FmdE, Molybdenum formylmethanofuran dehydrogenase operon. This entry represents the FmdE protein that is encode by the molybdenum formylmethanofuran dehydrogenase operon. FmdE does not co-purify with the molybdenum isozyme that is formed by FmdC and FmdB. The domain is typically found as a single copy, but is repeated in some sequence two to three times. It is also common place to find this domain co-occurs with a zinc-beta ribbon domain, suggesting that is may bind nucleic acid and be involved in transcription regulation.	4.75488e-19
NC_012918.1\|WP_015838296.1\|3540030_3540648_-\|LysE-family-transporter	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	4.86472e-16
NC_012918.1\|WP_015838300.1\|3544634_3545342_-\|GspB-domain-containing-protein	gnl\|CDD\|339769	pfam16537, T2SSB, Type II secretion system protein B. This is the B protein from some operons of bacterial secretion systems of type II. The exact function of the B protein is not known, though in the case of Vibrio cholerae there is a fusion protein between proteins A and B that includes an AAA domain, a PG_binding domains well as this domain at the C-terminus. Many of the other species have no A or B domain genes in this operon. The type II secretion pathway is conserved in Gram-negative bacteria that are prevalent in bacterial pathogens of plants (Pseudomonas fluorescens, Erwinia or Xanthomonas species), animals (Aeromonas hydrophila) and humans (Klebsiella oxytoca, Pseudomonas aeruginosa, Vibrio cholerae or Legionella pneumophila). Typical type II secretion systems (T2SSs) are encoded by a set of 12 to 16 gsp (general secretion pathway) genes organized into large operons including the conserved 'core' genes denoted C to O and in some bacterial species, as indicated above, extra gsp genes such as gspAB, gspN or gspS. A different nomenclature is used for Pseudomonas T2SSs, so the B gene is referred to as the P protein.	6.09451e-07
NC_012918.1\|WP_015838301.1\|3545342_3546953_-\|AAA-family-ATPase	gnl\|CDD\|132060	TIGR03015, pepcterm_ATPase, putative secretion ATPase, PEP-CTERM locus subfamily. Members of this protein are marked as probable ATPases by the nucleotide binding P-loop motif GXXGXGKTT, a motif DEAQ similar to the DEAD/H box of helicases, and extensive homology to ATPases of MSHA-type pilus systems and to GspA proteins associated with type II protein secretion systems. [Protein fate, Protein and peptide secretion and trafficking].	3.20646e-87
NC_012918.1\|WP_015838291.1\|3534102_3534561_+\|nitrogen-fixation-protein-FixH	gnl\|CDD\|377555	pfam05751, FixH, FixH. This family consists of several Rhizobium FixH like proteins. It has been suggested that suggested that the four proteins FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG.	1.05161e-19
NC_012918.1\|WP_015838292.1\|3534557_3536978_+\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|225127	COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism].	0
NC_012918.1\|WP_015838307.1\|3551871_3552228_-\|cytochrome-c	gnl\|CDD\|379187	pfam13442, Cytochrome_CBB3, Cytochrome C oxidase, cbb3-type, subunit III.	6.69371e-12
NC_012918.1\|WP_015838302.1\|3547093_3547711_-\|CAP-domain-containing-protein	gnl\|CDD\|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	2.80268e-21
NC_012918.1\|WP_015838299.1\|3542353_3544534_-\|ATP-dependent-RecD-like-DNA-helicase	gnl\|CDD\|273632	TIGR01448, recD_rel, helicase, putative, RecD/TraA family. This model describes a family similar to RecD, the exodeoxyribonuclease V alpha chain of TIGR01447. Members of this family, however, are not found in a context of RecB and RecC and are longer by about 200 amino acids at the amino end. Chlamydia muridarum has both a member of this family and a RecD. [Unknown function, Enzymes of unknown specificity].	0
NC_012918.1\|WP_015838306.1\|3550449_3551709_-\|HD-domain-containing-protein	gnl\|CDD\|225971	COG3437, COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms].	3.13037e-59
NC_012918.1\|WP_015838294.1\|3537601_3538261_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|372587	pfam13386, DsbD_2, Cytochrome C biogenesis protein transmembrane region.	5.54187e-39
NC_012918.1\|WP_015838298.1\|3541314_3542013_-\|amino-acid-racemase	gnl\|CDD\|224707	COG1794, RacX, Aspartate racemase [Cell envelope biogenesis, outer membrane].	4.06619e-76
NC_012918.1\|WP_049760130.1\|3548989_3550285_-\|nodulation-protein-NfeD	gnl\|CDD\|223961	COG1030, NfeD, Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones].	6.41198e-131
NC_012918.1\|WP_015838295.1\|3538722_3540021_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|319871	cd10549, MtMvhB_like, Uncharacterized polyferredoxin-like protein. This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.	2.60584e-12
NC_012918.1\|WP_157506169.1\|3538156_3538687_-\|diguanylate-cyclase	gnl\|CDD\|236577	PRK09581, pleD, response regulator PleD; Reviewed.	1.60904e-09
NC_012918.1\|WP_015838290.1\|3532862_3534086_+\|4Fe-4S-binding-protein	gnl\|CDD\|274278	TIGR02745, iron-sulfur_cluster-binding_protein, cytochrome c oxidase accessory protein FixG. Member of this ferredoxin-like protein family are found exclusively in species with an operon encoding the cbb3 type of cytochrome c oxidase (cco-cbb3), and near the cco-cbb3 operon in about half the cases. The cco-cbb3 is found in a variety of proteobacteria and almost nowhere else, and is associated with oxygen use under microaerobic conditions. Some (but not all) of these proteobacteria are also nitrogen-fixing, hence the gene symbol fixG. FixG was shown essential for functional cco-cbb3 expression in Bradyrhizobium japonicum.	1.18518e-84

>NC_012918.1|WP_015838298.1|3541314_3542013_-|amino-acid-racemase
MKTIGMIGGLGPEATLDYYKRIIEASRGAGTLDTPEIIIYSVSLQEVLDLAARREWSNLIYLLTAKVKALQKAGAEFAFISANTPHVVFDEVQAKSPLPLVSIVTATLEKAKGLGVTRVGLLGTKFTMEENFFAPPFSAAGISVVVPPLADRQYIQEKLMTEIELGVFKDETRDGLLAVIGRMKEQEHIDAVILGCTELPLILLKDEFGIPFLNTTAIHVECVVEYAKKERR
>NC_012918.1|WP_015838297.1|3540760_3541318_-|formylmethanofuran-dehydrogenase-subunit-E
MTAGNFRKGALVMLTLLLPSGAAALERVALAGSGNGAVFETLERFHGHVCAGSLMGARLGLAAKTALKAAGGEGKLKAKYFANSCSIDGVQVAAGTTAGNKAIEVVDAGENRLLLSAEKNGRQVEAHLTRVAEEKAKKFRELRGKGNALPVGSPERQQVERAVGDILSWFRNAPDVAVVQVKVVK
>NC_012918.1|WP_015838296.1|3540030_3540648_-|LysE-family-transporter
MFDFLTAGLVLGLSAGFSPGPLLMLVISETLHHGTRSGVRVALSPVITDLPIILATLLLLVKVSGYQGVLGGVSLAGGLFVLATGWDSIRTRPVQLDLPKEQPKSLRKGVLTNFLSPHPYLFWITVGAPLLTKSLNVGWTAFFAFVLSFYLSLVGAKVILAVAVGRSKAFLSGRLYLYTMRFLGGLLVLFALLLFKEGLELLGLV
>NC_012918.1|WP_015838295.1|3538722_3540021_+|4Fe-4S-dicluster-domain-containing-protein
MAERAQENGYHRLMQRVNKFPQGAPPSELLLKIYALLCSEEEARLLSLLPLRPFSAAKAARAWRMEKEAARGRLEQMASRSLLLDIERDGKMVYVLPPPMAGFFEFSLMRLRPDLDQKQLASLFFRYINVEDDFIRDLFAGGETPLGRVLVNEEAIPEEKVCQVLDYERASEVIGSATHIAVGLCYCRHKMLQVGKGCKAPLDICMTLNLAAQSLIRRGAARSVDAVEGLDLLQKARDLNLVQCADNVQRQVNFICHCCGCCCEGMIATRRLAIPNAMYTTNFTQATDPARCDGCGRCVAICPVDAISLVREPEGSGMPAKARLNSELCLGCGVCARNCHTKAVRLEAREKRILTPVNTAHRLVLMALERGKLQNLIFDNQAYLSHRALAAILGAILRLSPVKRLTASRQLKSHYLERLMADVDVTRFSRFE
>NC_012918.1|WP_157506169.1|3538156_3538687_-|diguanylate-cyclase
MRDYSSRNRANNREQAGGFCSLSLWEWAGVRRRRGQMSAGLRGTAHGKLQEDGGGAGALRRSRSWPWCSRIQRRKLPKGSGRGCGCCRKKALPHEASELGVVTISVGVSGGLVARGQDAEWFIKEADRALYFAKSGGRNRVALSAQCAPEPGDPHEGHGDACQPEHDPVQLAGYGA
>NC_012918.1|WP_015838294.1|3537601_3538261_+|sulfite-exporter-TauE/SafE-family-protein
MLVVWLAFLAGATGSFHCIGMCGGVVAALSLRDSEAPLRARIFSQLCYNAGRVTTYTLLGALAGFAGSSLDLVALKSASFWFPAGANLLVVMIGLSSALGLDALKLASFERGAASFLSRPLKRALSSRAPLASLPLGLVLGLLPCGMVYAPLIAAAGTGSALTGAATMAALGAGTVPVMLGFGTASSAVSGKLHRVMLRLAGVAVALMGVAGLWRTLGR
>NC_012918.1|WP_015838293.1|3536970_3537132_+|cbb3-type-cytochrome-oxidase-assembly-protein-CcoS
MASSLIALMGLSLFLGCGCWLFFLWAVQRGEFHDMERPKHRMLDEDEREKPQK
>NC_012918.1|WP_015838292.1|3534557_3536978_+|heavy-metal-translocating-P-type-ATPase
MTTVQFPCFHCGAEIPAGALVEERAGDATLSFCCHGCHGAYLVISGAGLADFYRRREWRESGLSPQAFQGKYQESYLARFVHPAGAASAIDIIIDGIRCASCVWLNEKIIGRIDGVQEVRVNYATGRARVTFDGSRTSPVRIFARIDELGYLPRPYTRNAAKEVALNEQKDLLFRFGTAAFLSMQLMAYAFALYAGYFQGIDEQMKNYLQLFSWLVTTPVVFYCGWPFLRGAWRGIVNGSPNMELLIATGALSSYCYSVYATFAGEEVYFETAAMIVTLILVGRLLENAAKRRASSGIERLMELCSGEAQRFKGDKLEPVDPSLLRPGDLILVSPGERFPVDGAITEGATDVDESAATGEPLPLYKKAGDRVIAGSCNLTGAVRVRCEREVEDSFIARVARLVEQAQSRRAPIQRLADRVSGYFVPAILTLAIATFCRHYSQSAQFGPSLMTALAVVVIACPCALGLATPTAILAGTGAAASAGVIFKGGDILERLSRVTVAVFDKTGTLTCGSPMLVDVQPAPGLSRGEVLALAAAVERGSLHPIAKAVREYAEANGVAYPVGEELVSLAGGGVTGRVAGEAVAVGSVCFLRRTGAGGVPERVESPEGGIVVGVARRGRYCGALVLKDRIREDAPGLVSYFKRGGIGTLLFSGDRQESTDKAALAAGIDLACGELSPAEKAAKIETLREEGETVLMVGDGINDAPALSAADVGCAVAGGTDIAMETSDLVLAKPDLERLAEAHRMARRTMAVVRQNLAWAFLYNLVGVPLAMTGRLTPVYAAAAMALSSICVVGNSLKLMRARNG
>NC_012918.1|WP_015838291.1|3534102_3534561_+|nitrogen-fixation-protein-FixH
MTKRTAKNTCCYRVVLMTLFGIFIAGMAATFFASAMPGSRVTDPDYYQNGLNYGRTRSGARNPGLTWTLTATLAGRDLLVRVRDEKGAPVAGGRLSLHPGKQGASSLPLQLTESAPGVFRAPRPATAEGELQGVLRFTRGEASASQRVVFFN
>NC_012918.1|WP_015838290.1|3532862_3534086_+|4Fe-4S-binding-protein
MRVGGKRSGRLAPWRKGVQWLATLLLLAIPFLRVGGESLLRLDAGSRTLLFFGASLRIEEFYLFLIVVLILVFGFLFVTMLFGRVWCGWLCPQTTLCDLADWLAARLGGARPAPWQRVARHLAYITLSALIACNLVWYFIAPPQFFQRLMTAGIGPVAGITLITVFFLVYLDLAFVRRSFCKTVCPYGRIQLMTMERGTLTLEFDPARKDACLRCGACVRACPMGIDIRDGLQVECINCGRCLDACREVMEKRGLQGLIHYSFGNLPGEPVRLNRKALLLGAVLLLLALALAAGVAGRKEATLKLQRTAGAEVKRLQDGSLVNFYTVYLENRATRTGIFSLQVAPLPGRRMELIGPVQGLQLAANENRKVDLALKVKPAPAGALNAELRLVSQERVLAATPLPVAVE
>NC_012918.1|WP_015838299.1|3542353_3544534_-|ATP-dependent-RecD-like-DNA-helicase
MKETPPTENVDRLSGSLERVTFHSEETGFCVLRVKVAGQRDLVTVTGAAASVTPGEYLECTGSWHNDRTHGMQFKAGHIKVVPPTTLEGIEKYLGSGMVHGIGAHFAKVLVKSFDAAVFDVIENHPERLLELPGIGRKRMESVAGAWVEQKAIREIMVFLQSNGLGTARAVRIYKSYGNEAIFKVTENPYRLALEIHGIGFKTADLLAAKLGIAPDSMIRAQAGVRHVLQEMSTSGHCAALRAELAESTASLLEIPQPVIESAIEAELAAENLVADQISGSPCVFLAPLYKAEVGVASGICRLRAGTPPWGGIVAEEAIPWVESQKGITLSASQRDAIRLALKSKVVVVTGGPGVGKTTLVNSILGVIGRRPLRVTLCAPTGRAAKRLAESTGMEAKTIHRLLEFDPQSFGFKRCKENPLHTDLLVMDEASMVDVVLMNKLLPAIPDHAGLIIVGDVDQLPSVGPGSVLSDIIESGAVPTVRLTEIFRQAAGSRIIVNAHRINRGELPLKDEGKELADFYFIPAATPEDIHDKLLQVVRERIPKRFGFDPVREVQVLTPMNRGGLGTRSLNAELQGVLNGRGEPKVERFGTSYAPGDKVIQTVNNYEKEVFNGDIGRIVEIRPEEGALTVDFDDRLVEYAFAELDEVSLAYATSIHKSQGSEYTAVVIPLAMQHYTMLERNLLYTAVTRGKKLVVVIGEQKALAMAVQNQKSHRRLTRLAGRIALT
>NC_012918.1|WP_015838300.1|3544634_3545342_-|GspB-domain-containing-protein
MSLILDALRKMEQERRSRRGAANDLRPEVLRYRQATQGKEPARYPVLLVGAALLCLGIGTGVLLKGNRNEAPREEPVAAAVAPAPQPVAAPLPAAPLPAAPAVAPAAPIALHSPQPAAAVTALPPSVQEEAAAVPARSKPSRASSYRSAPADGEGEGGSPRETATVQSGAPDISISGIAYQDERRMRRAVLNGVLVGEGAEIAGARVVEIKETKVRLSRGGQTFELTFSSGLQSR
>NC_012918.1|WP_015838301.1|3545342_3546953_-|AAA-family-ATPase
MYWESFGFKEAPFALTPNPSFLFLSSPHQEAFAHLLFAIESRAGFIELSGEVGTGKTTIVRTLLNQLDPETHRTALIFNPTLSPLGLLQEVNSEFGLDCVSHDMRELHTTLNAYLLEENRAGRTVVLVIDEAQNLSVEVLEQIRLISNLETDSDKLIQIVLVGQPELNALLSREELRQLDQRITVRYHLKPMSLDDTCAYVRHRIRFAADGREPLTFAQGAFKKIFSFSGGLPRLINGVCDRALLLAYTKECKEVSTEMAALAIADLRRSLPRRGRAVPMKALSAGVALCILAIAGFSMLSGSLLSKEPAALQPPPALSREAALAGLAASSEQENLLASVNAVLAAWQAPAALAAPGQPATLRGLARQRGMTATKVTGNLDTLARLDAPALLHLTVPGGGERLVALLRVDRDEVGVAPAVAGKRSLTRAELAQIWSGGATLLWKDFHGIFSRGKAGEKEAGVRLLQGLLKQVGCYDGAVNGEFTDKTQAAVAEFQRREQLTADGKLGGQTLMMLYRRAGGFFPPGLQTLTHNQGRI
>NC_012918.1|WP_015838302.1|3547093_3547711_-|CAP-domain-containing-protein
MKTLLRIWIFLLLSVTVAQASRGEMARELLAETNVARTDPARYAGYLKQIRGNFIGKGYRLPGSMNLVVTNEGVAAVDEAIAFLSRQRPVPALSWSPGLAKAAGELVREQAASGTTGHDGKSGDLKRRIERFGTWQGSIAENIGYGPDTARRMVMELIIDDGVSDRGHRKNIFERSFGTAGAACGPHPLYRNMCVMDFAVGYKSK
>NC_012918.1|WP_015838303.1|3547707_3547986_-|hypothetical-protein
MKAEVVSVRYRIPLTEGQAQKLRRTWPNGDPFYPYEKMERYLEPLLVEDLNWHHYSGNYLYFTVYGDDIEATLTDAMKVFEARLTMLEGKKP
>NC_012918.1|WP_015838304.1|3548422_3548917_+|hypothetical-protein
MRLSLYLEHGEQFSRAALKLPVRTPIDIESTLLNCFLEVLPVASSHYVGPDHLPGIEFPHPEIRVVFQLKEHPQVAAIYSIDVFVTDATLSLVSHAQGHTHVEINRRSSHIERLIANKQNGLLELIGCNHTLLIDRLSQAFLDLRGAYLNALCEEGCLPVPHHY
>NC_012918.1|WP_049760130.1|3548989_3550285_-|nodulation-protein-NfeD
MMRLFLPALLVLGLLLPMLLFGEQPQVAVISVRGPINPVTSGYLKQSLEAAGKRGDRLLLVELDTPGGLDTAMRDAVQAIFASPVPVAVYVTPSGARAASAGAVIGLSADILAMAPGTNIGAAHPVGLGGEKQDKVMASKIVNDAEAYVDGIAKKRGRNVELARRMVRDSISLTSEAALKQGVIDLVAADRQELLAKLEGRKVLRGGKEEVLHLSGARVTSYEMGTRDKILDAISNPDVAYMLMLLGMLGLFFELSNPGVILPGVIGGISLLLSFFALQTLPVNYAGIALILLAIVLFIAEVKVVSYGMLAVGGIVSMVLGSLMLFPSPEPYLRLSWSVIILTVLATAGFFTVVVAKVMQAHREKPITGVEGMLGEEGVADSDIDPEGRVLVRGEYWNAVSGETIRAGERVRVVEVKGLHLRVETIGKEKV
>NC_012918.1|WP_015838306.1|3550449_3551709_-|HD-domain-containing-protein
MGGPDSKLIKALHLGLEISQIKDIDLLLEKILTEARRFTNCDAGSIYVKEGDLLKFSHAQNDTMQRRLPVGRKLPYATFTVPISSSSIAGYVSLNGSILNIPDVSCIDPVYPFSFDSHYDEMTGYRTRSMLTVPLNNHRGDVIGVLQLINAMDADGSVVPFTDSNDDIITYFADAAANAVERAKMTREIILRMNRMAEMRDPKETGPHVNRVASYAVALYEAWAARNGLPQQEIDKIRDVLRMAAMLHDVGKVAISDTILKKPGRFTPEEFAIMKQHTVFGADLFSDIYSDFDESAAVVIMNHHERWDGNGYPGHIDPRTRQPLPGFEAEQGGARGKRGEEIPLFGRIVAIADVYDALTCSRCYKDAWDSDAVLDTIKQEAGKQFDPELVEVLLECCLDSFLQIAKLYPDQHPSPLAEP
>NC_012918.1|WP_015838307.1|3551871_3552228_-|cytochrome-c
MRCIVMVAVLSLALCAGCSARRGEPISQPLKIENAKMARGERAFMTYCNKCHPGGEKGLGFALNNKPLPGFMIKAQVRAGAGAMPAFSKELITGEQLDEIVEYATLLRNSPPPPRENR
>NC_012918.1|WP_015838308.1|3552237_3553704_-|glucose-dehydrogenase
MCKLIRIGCLLLLGSALCGCYEMRPTSGGGKLTVLPEDGVRALSPEDIALPSGYRIEAVATGLTFPSGVAFDERGTPFVVESGYSYGEVWTVPRLLKVENGKKVTVAQGGNNGPWTGVARLGGSFYVAEGGELEGGRILRIDADGSINPIVDGLPSRGDHHTNGPAAGPDGSLYFGIGTATNSAVVGEDNLKFGWLKRDPEFHDTPCADVTLRGENYASDDFLEGKGLVATGAFMPFGIYTLPGEVVYGEVPCNGAVLKVPPSGGRPQLVAWGFRNPFGLAFSPQGKLYVTDNGYDERGSRPVFGASDVLWEVTPGTWYGWPDFSAGLPLDYGNQFKPPLRHRPKPLLAEHPNVPPAPAAILPVHASANGLDFSRSERFGHRGEVFVALFGDQSPGTGKVMGPVGFKVVRVNVADGVIRDFAVNKGEKNAPASAFGSGGLERPLAARFDPSGEALYVVDFGMLKETVKGSIPMKNTGVLWRITREDQE

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Crispr_ID: NC_012918_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012918_12

4196530-4196636

Orphan

Consensus_repeat	Method
CTAACGTCCCCCCCTTTGCGAAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012918_12

>merge|NC_012918|12|4196530-4196636|CRISPRCasFinder
CTAACGTCCCCCCCTTTGCGAAGGTTCATCGGGAAATTCCGGGGAGCATCGCGGGTATCTGCCCAATAAGCGCTGCACGAGCACTCACGTCCCCCCCTTTGCGAAGG

>NC_012918|12|12|4196530-4196636|CRISPRCasFinder
CTAACGTCCCCCCCTTTGCGAAGG	TTCATCGGGAAATTCCGGGGAGCATCGCGGGTATCTGCCCAATAAGCGCTGCACGAGCA
CTCACGTCCCCCCCTTTGCGAAGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012918.1\|WP_015838815.1\|4190824_4191895_-\|cobalt-precorrin-5B-(C(1))-methyltransferase	unknown	unknown	gnl\|CDD\|376646
NC_012918.1\|WP_015838827.1\|4204268_4205162_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_012918.1\|WP_015838817.1\|4192680_4193064_-\|sirohydrochlorin-cobaltochelatase	unknown	unknown	gnl\|CDD\|239509
NC_012918.1\|WP_015838820.1\|4195207_4196233_+\|3-deoxy-7-phosphoheptulonate-synthase	unknown	unknown	gnl\|CDD\|181535
NC_012918.1\|WP_015838812.1\|4187719_4188505_-\|precorrin-4-C(11)-methyltransferase	unknown	unknown	gnl\|CDD\|381168
NC_012918.1\|WP_015838816.1\|4192030_4192681_-\|precorrin-8X-methylmutase	unknown	unknown	gnl\|CDD\|376825
NC_012918.1\|WP_015838813.1\|4188646_4189357_-\|precorrin-2-C(20)-methyltransferase	unknown	unknown	gnl\|CDD\|381172
NC_012918.1\|WP_012773954.1\|4196769_4197954_+\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NC_012918.1\|WP_015838824.1\|4201797_4202685_+\|Hsp33-family-molecular-chaperone-HslO	unknown	unknown	gnl\|CDD\|234643
NC_012918.1\|WP_015838811.1\|4186495_4187539_-\|cobalt-precorrin-5A-hydrolase	unknown	unknown	gnl\|CDD\|235610
NC_012918.1\|WP_015838828.1\|4205158_4205680_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239516
NC_012918.1\|WP_157506185.1\|4198862_4201241_+\|U32-family-peptidase	unknown	unknown	gnl\|CDD\|223896
NC_012918.1\|WP_015838821.1\|4198048_4198549_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015838825.1\|4202972_4203653_+\|cyclase-family-protein	unknown	unknown	gnl\|CDD\|224790
NC_012918.1\|WP_015838819.1\|4194410_4194860_-\|DedA-family-protein	unknown	unknown	gnl\|CDD\|224159
NC_012918.1\|WP_015838826.1\|4203660_4204092_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|184604
NC_012918.1\|WP_015838814.1\|4189356_4190574_-\|bifunctional-cobalt-precorrin-7-(C(5))-methyltransferase/cobalt-precorrin-6B-(C(15))-methyltransferase	unknown	unknown	gnl\|CDD\|381171
NC_012918.1\|WP_015838823.1\|4201243_4201801_+\|hypothetical-protein	unknown	unknown	unknown
NC_012918.1\|WP_015838818.1\|4193079_4194396_-\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NC_012918.1\|WP_015838829.1\|4205900_4206353_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223976

Protein	Function_ID	Function_description	E-value
NC_012918.1\|WP_015838815.1\|4190824_4191895_-\|cobalt-precorrin-5B-(C(1))-methyltransferase	gnl\|CDD\|376646	pfam01888, CbiD, CbiD. CbiD is essential for cobalamin biosynthesis in both S. typhimurium and B. megaterium, no functional role has been ascribed to the protein. The CbiD protein has a putative S-AdoMet binding site. It is possible that CbiD might have the same role as CobF in undertaking the C-1 methylation and deacylation reactions required during the ring contraction process.	6.52964e-127
NC_012918.1\|WP_015838827.1\|4204268_4205162_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	2.30723e-72
NC_012918.1\|WP_015838817.1\|4192680_4193064_-\|sirohydrochlorin-cobaltochelatase	gnl\|CDD\|239509	cd03416, CbiX_SirB_N, Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase, responsible for the chelation of Co2+ into sirohydrochlorin, an important step in the vitamin B12 biosynthetic pathway. CbiX often contains a C-terminal histidine-rich region that may be important for metal delivery and/or storage, and may also contain an iron-sulfur center. Both are found in a wide range of bacteria. This subgroup also contains single domain proteins from archaea and bacteria which may represent the ancestral form of class II chelatases before domain duplication occurred.	1.20103e-32
NC_012918.1\|WP_015838820.1\|4195207_4196233_+\|3-deoxy-7-phosphoheptulonate-synthase	gnl\|CDD\|181535	PRK08673, PRK08673, 3-deoxy-7-phosphoheptulonate synthase; Reviewed.	0
NC_012918.1\|WP_015838812.1\|4187719_4188505_-\|precorrin-4-C(11)-methyltransferase	gnl\|CDD\|381168	cd11641, Precorrin-4_C11-MT, Precorrin-4 C11-methyltransferase (CbiF/CobM). Precorrin-4 C11-methyltransferase participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways in bacteria. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. In the aerobic pathway, CobM catalyzes the methylation of precorrin-4 at C-11 to yield precorrin-5. In the anaerobic pathway, CibF catalyzes the methylation of cobalt-precorrin-4 to cobalt-precorrin-5. Both CibF and CobM, which are homologous, are included in this model. There are about 30 enzymes involved in vitamin B12 synthetic pathway. The enzymes involved in the aerobic pathway are prefixed Cob and those of the anaerobic pathway Cbi. Most of the enzymes are shared in both pathways and several of these enzymes are pathway-specific.	1.61336e-138
NC_012918.1\|WP_015838816.1\|4192030_4192681_-\|precorrin-8X-methylmutase	gnl\|CDD\|376825	pfam02570, CbiC, Precorrin-8X methylmutase. This is a family Precorrin-8X methylmutases also known as Precorrin isomerase, CbiC/CobH, EC:5.4.1.2. This enzyme catalyzes the reaction: Precorrin-8X <=> hydrogenobyrinate. This enzyme is part of the Cobalamin (vitamin B12) biosynthetic pathway and catalyzes a methyl rearrangement.	1.39533e-98
NC_012918.1\|WP_015838813.1\|4188646_4189357_-\|precorrin-2-C(20)-methyltransferase	gnl\|CDD\|381172	cd11645, Precorrin_2_C20_MT, Precorrin-2 C20-methyltransferase, also named CobI or CbiL. Precorrin-2 C20-methyltransferase (also known as S-adenosyl-L-methionine--precorrin-2 methyltransferase) participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways in bacteria. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. Precorrin-2 C20-methyltransferase catalyzes methylation at the C-20 position of a cyclic tetrapyrrole ring of precorrin-2 using S-adenosylmethionine as a methyl group source to produce precorrin-3A. In the anaerobic pathway, cobalt is inserted into precorrin-2 by CbiK to generate cobalt-precorrin-2, which is the substrate for CbiL, a C20 methyltransferase. In Clostridium difficile, CbiK and CbiL are fused into a bifunctional enzyme. In the aerobic pathway, the precorrin-2 C20-methyltransferase is named CobI. This family includes CbiL and CobI precorrin-2 C20-methyltransferases, both as stand-alone enzymes and when CbiL forms part of a bifunctional enzyme.	3.52579e-97
NC_012918.1\|WP_012773954.1\|4196769_4197954_+\|IS4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	4.44683e-14
NC_012918.1\|WP_015838824.1\|4201797_4202685_+\|Hsp33-family-molecular-chaperone-HslO	gnl\|CDD\|234643	PRK00114, hslO, Hsp33 family molecular chaperone HslO.	8.50179e-131
NC_012918.1\|WP_015838811.1\|4186495_4187539_-\|cobalt-precorrin-5A-hydrolase	gnl\|CDD\|235610	PRK05788, PRK05788, cobalt-precorrin 5A hydrolase.	2.51882e-95
NC_012918.1\|WP_015838828.1\|4205158_4205680_-\|NUDIX-hydrolase	gnl\|CDD\|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	1.4957e-50
NC_012918.1\|WP_157506185.1\|4198862_4201241_+\|U32-family-peptidase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	3.83595e-100
NC_012918.1\|WP_015838825.1\|4202972_4203653_+\|cyclase-family-protein	gnl\|CDD\|224790	COG1878, COG1878, Kynurenine formamidase [Amino acid transport and metabolism].	1.5903e-57
NC_012918.1\|WP_015838819.1\|4194410_4194860_-\|DedA-family-protein	gnl\|CDD\|224159	COG1238, COG1238, Predicted membrane protein [Function unknown].	1.82251e-34
NC_012918.1\|WP_015838826.1\|4203660_4204092_-\|hypothetical-protein	gnl\|CDD\|184604	PRK14283, PRK14283, chaperone protein DnaJ; Provisional.	0.00163793
NC_012918.1\|WP_015838814.1\|4189356_4190574_-\|bifunctional-cobalt-precorrin-7-(C(5))-methyltransferase/cobalt-precorrin-6B-(C(15))-methyltransferase	gnl\|CDD\|381171	cd11644, Precorrin-6Y-MT, Precorrin-6Y methyltransferase (also named CbiE). CbiE (precorrin-6Y methyltransferase, also known as cobalt-precorrin-7 C(5)-methyltransferase, also known as cobalt-precorrin-6Y C(5)-methyltransferase) catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8. It participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways in bacteria. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. CbiE functions in the anaerobic pathway, it is a subunit of precorrin-6Y C5,15-methyltransferase, a bifunctional enzyme: cobalt-precorrin-7 C(5)-methyltransferase (CbiE)/cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) (CbiT), that catalyzes two methylations (at C-5 and C-15) in precorrin-6Y, as well as the decarboxylation of the acetate side chain located in ring C, in order to generate precorrin-8X. CbiE and CbiT can be found fused (CbiET, also called CobL), or on separate protein chains (CbiE and CbiT). In the aerobic pathway, a single enzyme called CobL catalyzes the methylations at C-5 and C-15, and the decarboxylation of the C-12 acetate side chain of precorrin-6B.	2.31355e-75
NC_012918.1\|WP_015838818.1\|4193079_4194396_-\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	1.93319e-83
NC_012918.1\|WP_015838829.1\|4205900_4206353_+\|peptidylprolyl-isomerase	gnl\|CDD\|223976	COG1047, SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones].	7.87038e-39

>NC_012918.1|WP_015838820.1|4195207_4196233_+|3-deoxy-7-phosphoheptulonate-synthase
MIVVMKAGAAKKERDAVTKRIKELGYTPHIIHGTTRDVIGAVGDERGKSVLQTLESMQGVESVVPILQPYKLASKEVKKEASIVRISDTLAIGGKELVVMAGPCSVENEEQIIESALAVKAAGAQMLRGGAFKPRTSPYSFQGLEEEGLKLLAKAREITGLPFVTEIIDPDSVDLVASYSDMLQIGARNSQNFALLKKVGQIDKPILLKRGMSMTIQEFLMSAEYIMSEGNQSVILCERGIRTFETATRNTLDLSAIPVLKSKTHLPIVIDPSHGTGNYHYIAPMSFAAVAAGADGLIIEVHPDPEKASSDGPQSLKPKKFQALMDKLRLFAEAADKTLGA
>NC_012918.1|WP_015838819.1|4194410_4194860_-|DedA-family-protein
MQDWLVNYGLYSLFILSFLASTLLPLGSEWMVATMILAGEKAWAVVAVATAGNYLGALSTYWIGLYGGDFLKRRVLRMDDTSTKKAEKFYHRFGSISLLFSFLPVIGDPLCLVGGVLRISFIRFTLLVASGKLARYAAVAWLTLQGAAL
>NC_012918.1|WP_015838818.1|4193079_4194396_-|insulinase-family-protein
MPSCTKKVLPNGLRLVSVEMPHLHSAEIAIYIKAGGRDDTPGKAGISHFLEHMLFRGSSEFATSLELEIAFEAIGGSVNAATDEETTCYFSRVHPDQVPEGIRLFSSMLLAPTLEGIEIEKRIITEEALEDINERGEETNTSNLCSKLLWPGHPLGTPTIGYLESIKGFTEEDLRGYLLDHYVPENAVIVAAGRHDAQTFFASCEKHFAGWTGAKPPLPAPVHELQEEPRTVFVKDSDSQVNLQIAFRGFARHDKRIMALRLMRRILCGGGSSRLHLSLREKLGIVYSVDASLSAYEETGAFAIELATAPENLVLAVSEVLHEVKSLAFEEVGETELSRVKEGYFYDLEYSSDSTYEMQVRYGWGELMTLVRTIDEDRAEAASIAPAQIRETARVLFDPSNLTLAAVGPWKAPSKKVVEKLIREYRKGWGKAWPQERD
>NC_012918.1|WP_015838817.1|4192680_4193064_-|sirohydrochlorin-cobaltochelatase
MSTALLIMAHGSRIAEANDAVHEIAARVQRMTKFDIVEVSFREQHLPNIQQGVDACVAKGAQRILLVPYFLYMGAHVLEDLPEELDEAKRRHPGIEMVLGKHLGVHDKLAEVVVERIAETLTEERWH
>NC_012918.1|WP_015838816.1|4192030_4192681_-|precorrin-8X-methylmutase
MSVHMRPEEIEAESFRIIEEELGPHDWSAQDWPLVRRAIHTSADFDYARNMLIAKGAVDSGIAALKAGCGIVTDTTMIISGMSKERLKPFGVLVSCYVADPQVAKDAKAQLITRSIVAMRKGARDPKNGVFVIGNAPTALYELIRLIREERVKPRLIVALPVGFVGAAESKEALKELANDFPELPFITNTGRKGGSNVAAAVMNAILIQAEASSRG
>NC_012918.1|WP_015838815.1|4190824_4191895_-|cobalt-precorrin-5B-(C(1))-methyltransferase
MSGKELRYGFTTGACAAAAVKAAAQMLRDQAMVREVELMLPCGIGANFQVHGGVLRDNTASCYVVKDAGDDPDVTNGAEIHVTASIEFFTKNEIKIEGGTGIGRVTKPGLAVPVGAWAINPVPRSMILEVVKEVFALRCIPATLTFSISIPNGEELAKRTLNERLGIVGGLSILGTTGIVKPISAKAWTDTVDASVDVALACGARTVVLATGRSSEIVAQKHLSLSEEAFVMMGDHFGYAMRSCASKGVPEVVVAGQFAKLVKIACGHEQTHVTSSQMDLDALAWWLREVPATAHLEQMAREANTARHLLEASGYNKALIELVCSRVLKVCADVAPWMKARVMLAGYHGDLLYFSP
>NC_012918.1|WP_015838814.1|4189356_4190574_-|bifunctional-cobalt-precorrin-7-(C(5))-methyltransferase/cobalt-precorrin-6B-(C(15))-methyltransferase
MPQQKIYLVGAGIEGWEGFGKQALEAIEGAQVLIGHKRLLDIFPEFKGEKRLLDDLSITLEYLKTTDKRAVVLGSGDPNFFGIARFLLRNLPKDRVEIFPNVTSVQYAFARIKEPWDDATFVSVHGRGIKPALDRIIASEKIAILTDSVNTPAVLARELIARGAEGYEAWVCEDLGLASEKFTKTDVKGLAELTCSPLNILILIKTWEPNLQNYPVIGIRDDEFATAKKLITKEEVRAITLGKLQLQDDLVMWDIGAGSGSVSIEAANLMPNGRIFALEKNPQYLVFLKENLKKFAARNVMVVEAFAPEGLEELPDADRVFIGGSGGMLEEIIDAVDKRLKPDGFIVINAVTLDTLTKSVEFLEDHGYTVEVTCVNISKTRNLTEYKMFAAHNPVYVIAAWKGEE
>NC_012918.1|WP_015838813.1|4188646_4189357_-|precorrin-2-C(20)-methyltransferase
MAVVYAVGVGPGDPELLTRKAERILRSVDVICAPTGAAEAGSYALSIVEPFLDRERQEVLVQVFPMVKDQQGLDPFWEEAADQVAQRIAAGKDVAFITIGDPFLYSTYLYIHRIFLAKYPEIKIEVVPGISSILASSAISGLPLGLGPERIAILPATYEHDELKKTLEEFDTVVLMKVSRVFDTVYAVLKELGRERGGVFVRRVGSPEEEVHHDLEALVGQKLDYLSMLIVRKNPL
>NC_012918.1|WP_015838812.1|4187719_4188505_-|precorrin-4-C(11)-methyltransferase
MNEQNKVHFVGAGPGDAELITVKGARLLREADVVVYAGSLVDRELVRTYAPDARVFDSAGMDLEQTTRVLAQAVVDGQKAVRLHTGDPSIYGAIQEQMEELDRLGIGYDVVPGVTSAFAAAAALKQELTLPEVSQTVVITRLAGRTPVPEREQLANIATIGATLVIYLSISMVEKVVEELLSGAYQPDTPVAVVAKASWADEQVIRGTLSDIAGKVREAGIGKQALIVVGDVLRARNEGMKAKSLLYDKGFTHGCREGIVS
>NC_012918.1|WP_015838811.1|4186495_4187539_-|cobalt-precorrin-5A-hydrolase
MQVAIIAITGNGARLGKVLQEGIPDSRLFVIEKHAGPSCHPFSEPVPALISRLWPECRGFICIMATGIVVRCIAPLLQAKDRDPAVVVLDDAGKFAVSLLSGHLGGANALAKSCASLTGCTPVVTTATDANDLPSFDLLAQENGWVIDDLSRVKALNALLLEGREIAVADPTGRVRRYCAGRGNLVFVADAEKAAASGAAGLLLVTNRTLPSPLDRQRTLVLRPVNLHLGIGCNRGTAMEEIEAVVMANLERLGLSVKSVKCLATARAKEDEEGLLAFAARLGVPLIFFDNEELNGVAVPSPPSAHAMAAIGARGVAEPAALLASGGGTLILKKVKDGNVTLSIAQG
>NC_012918.1|WP_012773954.1|4196769_4197954_+|IS4-family-transposase
MRHSLRTSTLRARLRFKKAFKPMYDPVQRYLSVITPLTSKGDRPLQLSFEDQLKALIYFHLHEFSSGRELLQALEQDDFAKECVAPPKGIKKSAFFEAVNNRGLEQLAELFKLLLKDAKNVIPAEFADIGNLVAIDGSYIDAVMSMDWADYSSTHNKAKAHVAFDINRGIPKDLILTDGNQTERQFVERMIGPDETAVLDRGYQCNANFDQWQENEKKFICRIQARSNKKVIRENPIARGSIIFYDAVVLLGAPSTRAKKEVRVVAYRVEGKDFWIATNRHDLTALQIAEAYKLRWHIESFFAWWKRHLSVYHLIARSQYGLTVQILSGLITYLLLAMYCQREHNEPVSVHRVRELRHQMARDAVAMTSQTPSPKRAKLQRNTRLLMKRRKAKT
>NC_012918.1|WP_015838821.1|4198048_4198549_+|hypothetical-protein
MRSLALLALILVLSSPLSLAAKESGKRAATGAAQSGVASSQEVLGDFEKILDLWRDGSYDELYGRTTGGRESKETFARKLTAAPRRPACCWEKMQDVEVSSKGAGKAVVRARLGFEGSVPGTQFVTKSIKLQKEGSVWAISQSDLLSLADYSKKRKLYRYLPPKQK
>NC_012918.1|WP_157506185.1|4198862_4201241_+|U32-family-peptidase
MPMNEKKISVNKPELLSPAGSLEAFFAAMEKGADAVYAGLRDFSARAKAKNFTLAQMERMTAYAHSLGKKTYVTLNTLVKEAELPLLIDNLAALEAMRVDGVILQDMAVARLAREFFPGIPLHASTQMTIHNSLGVRQLEELGFERVVLARELHIDEIKSIVASSKAEIECFIHGALCFSFSGQCYFSSFLGGHSGNRGRCAQPCRRQYKHKGKEGYYLSTNDFSSIEMVPQLIEAGVASLKIEGRMKSAEYVASVIGAYRMVLDAPHGSYDAAVAEAKALLKLSFGRVPTKGFLASHNPTDISTPSIKGATGRYLGDIREMRGNRISFETRDRLHVGDRIRVQPKSDMAGRAFTIKELYLGGKKVMNVKENTLVSTPSPFPFKLGDSVFKVSSETAFTMSENACLKRLEGAKGDSIPCKLKLLHQDQSLRIEAEVLGQNFATEFELGPLEPSRSSDMEGVLRAQFSKSGDTQFILASLSAPEFPAIMIPPPRLKEIRRNFYAWLAQASVGALKQRSARGREEALASLVRQRPAAFRGKEGLAVKLEQVRDWHELHRDLVDTVILPVSKANMHQFPGFARKLKGDEGKVIWQLPFIIFEAELQFYRDAVEMIMRGGFRRFELTNLSHFQFFKGTDAELNTDYRLFSLNSQALLSWQELGVKRATLYMEDDRTNMGQLLAGELKIDRGVLLYAPVPVITSKIAIKEIKGDAPLASDRGDLYGVKVKDHLTVVSAQTPFALTQYRSELRQMGCGSFLLDLSQLQPEERDRALEAYRKGVAVPAASEFNYSAGLV
>NC_012918.1|WP_015838823.1|4201243_4201801_+|hypothetical-protein
MGIFDKIKERINDRLSDPAFMELVQEQSLKDLLVRREFRITQAYLQREFLNKLIDDEIQEFSIVLFDGYGEIAGKMKKRLLPFAIPFSATFSIQGIEFSSSRKCVFLKLDHVAPVDFDWLTQKVVERIPFLSGTGALIVCDLTRVPRLAELFAQRVKGISIWDFITLKELWLRKGEIVGRVGVVL
>NC_012918.1|WP_015838824.1|4201797_4202685_+|Hsp33-family-molecular-chaperone-HslO
MTDYLVRAIAKSGSVRALVCVTTATVGEICKRHDTLPTATAALGRGITAGALMGSLVKTGQRVALRFEGNGPLKKIVIEADANGSVRGYVGDPKVHLLRPDGALDVNNALGRAGFLTVAKDLGLKEPYRGTVQLYTSGIAEDLALYLVESEQIPSAVGIAEFIEQDGTVAAVGGFLIQAVPPVDPLVVEELMTRIEQLPPLSELLHEGGNPEQILEQLLAGIPYDILEKRNIAFACSCSRERIERVLLSMGKKELSSMKKDQHGSEVTCEFCGERYLFDEADLDRIIAEIAKQES
>NC_012918.1|WP_015838825.1|4202972_4203653_+|cyclase-family-protein
MRIHDITVPLSSDLPVYPGDPGITVEPFSRISQGDSANVSHISMGSHSGTHLDAPFHFDDAGTTVDEIALETLIGKALVLEILGTKEIGRQELEKFRIEGEERLLLKTDNSKLWQQKGFSEEYAALTKDGAQYLRDAGVRLVGIDYLSIEGFHGEGDVHRTLLEDGILVIEGLNLEGIKAGHYQLICLPLKLKGGDGAPVRALLVGGSDSATESEFDPHTSKWPLA
>NC_012918.1|WP_015838826.1|4203660_4204092_-|hypothetical-protein
MKKKLFLVLVPAVLIIVGAFGVWANDQTVAQPGCSKCVKAVNAPVQAQPGCEKCAKQNAIDGSAAAPCPNCANCVKAMDCPNTPNCQNCPKGNGTDVKAGCANCAKMKDAAAAPPAGCDKCAKLKQPAQKGCCNKGNNKYQPL
>NC_012918.1|WP_015838827.1|4204268_4205162_-|RluA-family-pseudouridine-synthase
MILTARVDAELAGTRLDDAAKTLFPQYSKGEIRRIIDWGGCYLSQTLVRVASRTVKEGEEIALGIMEAERCIELVYKKEELLYEDKDFLAVYKAAGFNSQRTPYQLKGTVEYAVECYMKSIGLRDPSRVVHRLDRGTSGVMFFPKHKQAATLISNLLKDGKVQKTYWALVSGSPDQQSWKVEAPLGKVSKFKYGVALNGKPARTLFRVVGEGAGVTAVEAKPLTGRTHQIRVHLAYSGFPIIGDETYGGIPAARMMLHCRGMRFTGAKGKVIEAFAPADADFRAAATEGIWEESAEA
>NC_012918.1|WP_015838828.1|4205158_4205680_-|NUDIX-hydrolase
METKNRSVLFRGIVVDIEQMDVLIGEQGWYTYQVVRHPGGAAVLPLHDDGSVTLIRQLRPAIDDFLMEIPAGRLSKGEDPAACAARELIEETGLRAEKFTPLGILHPSPGVFDEVVHLYLATGLTAGKAEPEDYEEISSIRIPLPKALEMAADGSITDGKTIAALLRAQRHIG
>NC_012918.1|WP_015838829.1|4205900_4206353_+|peptidylprolyl-isomerase
MAQAKEGDRVKVHYTGRLDDGSIFDSSECAEDDCGCGHGPIEFTIGQGEVIPGFEAGIKGLSVGESKTVHIPVEEAYGERVEEMVAVVPRGDLPPEMKPEVGQQLEVTQDDGQVFSVLVVEVTDETITIDANHPLAGQPLNFELKLVEIL

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_012918_12	12.1\|4196554\|59\|NC_012918\|CRISPRCasFinder	4196554-4196612	59	NC_012918.1	2955859-2955917	0	1.0
NC_012918_12	12.1\|4196554\|59\|NC_012918\|CRISPRCasFinder	4196554-4196612	59	NC_012918.1	3603239-3603297	0	1.0
NC_012918_12	12.1\|4196554\|59\|NC_012918\|CRISPRCasFinder	4196554-4196612	59	NC_012918.1	3603322-3603380	0	1.0
NC_012918_12	12.1\|4196554\|59\|NC_012918\|CRISPRCasFinder	4196554-4196612	59	NC_012918.1	3590622-3590680	1	0.983

1. spacer 12.1|4196554|59|NC_012918|CRISPRCasFinder matches to position: 2955859-2955917, mismatch: 0, identity: 1.0

ttcatcgggaaattccggggagcatcgcgggtatctgcccaataagcgctgcacgagca	CRISPR spacer
ttcatcgggaaattccggggagcatcgcgggtatctgcccaataagcgctgcacgagca	Protospacer
***********************************************************

2. spacer 12.1|4196554|59|NC_012918|CRISPRCasFinder matches to position: 3603239-3603297, mismatch: 0, identity: 1.0

ttcatcgggaaattccggggagcatcgcgggtatctgcccaataagcgctgcacgagca	CRISPR spacer
ttcatcgggaaattccggggagcatcgcgggtatctgcccaataagcgctgcacgagca	Protospacer
***********************************************************

3. spacer 12.1|4196554|59|NC_012918|CRISPRCasFinder matches to position: 3603322-3603380, mismatch: 0, identity: 1.0

ttcatcgggaaattccggggagcatcgcgggtatctgcccaataagcgctgcacgagca	CRISPR spacer
ttcatcgggaaattccggggagcatcgcgggtatctgcccaataagcgctgcacgagca	Protospacer
***********************************************************

4. spacer 12.1|4196554|59|NC_012918|CRISPRCasFinder matches to position: 3590622-3590680, mismatch: 1, identity: 0.983

ttcatcgggaaattccggggagcatcgcgggtatctgcccaataagcgctgcacgagca	CRISPR spacer
ttcatcggggaattccggggagcatcgcgggtatctgcccaataagcgctgcacgagca	Protospacer
*********.*************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP024150	Escherichia coli strain 14EC033 plasmid p14EC033c, complete sequence	29367-29392	2	0.923
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	CP024913	Cyanobacterium sp. HL-69 plasmid pCHL69-1, complete sequence	14149-14174	3	0.885
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	CP024913	Cyanobacterium sp. HL-69 plasmid pCHL69-1, complete sequence	14107-14132	4	0.846
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	985721-985746	4	0.846
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	246021-246046	4	0.846
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	409272-409297	4	0.846
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	409557-409582	4	0.846
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	196908-196933	4	0.846
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	209580-209605	4	0.846
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	209848-209873	4	0.846
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	LR134127	Klebsiella aerogenes strain NCTC10006 genome assembly, plasmid: 7	169176-169201	4	0.846
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	409416-409441	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	209714-209739	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP026279	Klebsiella oxytoca strain KONIH2 plasmid pKOR-b08d, complete sequence	30991-31016	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP053606	Escherichia coli strain NEB_Turbo plasmid F', complete sequence	44339-44364	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP053608	Escherichia coli strain NEB5-alpha_F'Iq plasmid F'Iq, complete sequence	44338-44363	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP026274	Klebsiella oxytoca strain KONIH4 plasmid pKPC-4b66, complete sequence	192412-192437	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP029112	Escherichia coli strain AR436 plasmid unnamed3, complete sequence	24643-24668	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP026205	Escherichia coli strain ECONIH5 plasmid pKPC-e3ee, complete sequence	30621-30646	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP019841	Enterobacter roggenkampii strain R11 plasmid pASM2, complete sequence	37770-37795	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP026172	Klebsiella pneumoniae strain KPNIH50 plasmid pKPN-bbef, complete sequence	137709-137734	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP010365	Enterobacter hormaechei subsp. oharae strain 34978 plasmid p34978-70.092kb, complete sequence	39735-39760	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP029833	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence	132596-132621	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP026398	Klebsiella pneumoniae strain KPNIH48 plasmid pKPN-edaa, complete sequence	236147-236172	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP008843	Klebsiella michiganensis strain M1 plasmid pKOXM1B, complete sequence	143044-143069	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP017452	Klebsiella sp. LTGPAF-6F plasmid unnamed2, complete sequence	83054-83079	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	AP017993	Planktothrix agardhii NIES-204 plasmid plasmid2 DNA, complete sequence	44871-44896	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_AP023206	Escherichia coli strain TUM18781 plasmid pMTY18781-1_lncX3, complete sequence	262905-262930	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_AP023206	Escherichia coli strain TUM18781 plasmid pMTY18781-1_lncX3, complete sequence	75916-75941	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP026232	Citrobacter freundii complex sp. CFNIH4 plasmid pKPC-c9fd, complete sequence	24038-24063	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP014271	Escherichia coli K-12 strain K-12 DHB4 plasmid F128-(DHB4), complete sequence	44335-44360	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP010382	Enterobacter hormaechei subsp. steigerwaltii strain 34998 plasmid p34998-53.129kb, complete sequence	31852-31877	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP050068	Klebsiella aerogenes strain 035 plasmid p35, complete sequence	336779-336804	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_KT935446	Klebsiella pneumoniae strain Kp2964 plasmid 2964TF, complete sequence	111762-111787	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP043437	Enterobacter sp. LU1 plasmid unnamed	422274-422299	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP035215	Klebsiella michiganensis strain M82255 plasmid pKOCBH-A, complete sequence	173244-173269	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP027617	Klebsiella pneumoniae subsp. ozaenae strain AR_0096 plasmid unnamed5, complete sequence	44039-44064	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP026184	Klebsiella pneumoniae strain KPNIH49 plasmid pKPN-af73, complete sequence	6365-6390	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP042547	Klebsiella michiganensis strain C52 plasmid pC52_002, complete sequence	89390-89415	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP032208	Klebsiella pneumoniae strain AR_0109 plasmid unnamed2, complete sequence	234959-234984	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP011646	Klebsiella pneumoniae strain CAV1596 plasmid pKPC_CAV1596-97, complete sequence	66872-66897	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_AP023208	Escherichia coli strain TUM18781 plasmid pMTY18781-3, complete sequence	2512-2537	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_AP023208	Escherichia coli strain TUM18781 plasmid pMTY18781-3, complete sequence	9789-9814	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP018077	Sulfitobacter sp. AM1-D1 plasmid unnamed1, complete sequence	170043-170068	5	0.808
NC_012918_11	11.1\|3542129\|26\|NC_012918\|CRISPRCasFinder	3542129-3542154	26	NZ_CP027125	Escherichia coli strain AR_0374 plasmid unnamed3	30781-30806	5	0.808
NC_012918_3	3.1\|370855\|27\|NC_012918\|CRISPRCasFinder	370855-370881	27	MG592395	Vibrio phage 1.009.O._10N.261.51.C9, partial genome	43351-43377	6	0.778

1. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP024150 (Escherichia coli strain 14EC033 plasmid p14EC033c, complete sequence) position: , mismatch: 2, identity: 0.923

acccctctcccacagggcgaggggta	CRISPR spacer
acccctctcccactgggagaggggta	Protospacer
************* *** ********

2. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to CP024913 (Cyanobacterium sp. HL-69 plasmid pCHL69-1, complete sequence) position: , mismatch: 3, identity: 0.885

acccctctcccacagggcgaggggta	CRISPR spacer
acccctctcccacagagcgaggggag	Protospacer
***************.******** .

3. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to CP024913 (Cyanobacterium sp. HL-69 plasmid pCHL69-1, complete sequence) position: , mismatch: 4, identity: 0.846

acccctctcccacagggcgaggggta	CRISPR spacer
tgccctctcccacagagcgaggggaa	Protospacer
  *************.******** *

4. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.846

acccctctcccacagggcgaggggta	CRISPR spacer
tcccctctcccagagggcgaggggag	Protospacer
 *********** *********** .

5. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

acccctctcccacagggcgaggggta	CRISPR spacer
gcccctctcccaccgggagaggggtt	Protospacer
.************ *** *******

6. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

acccctctcccacagggcgaggggta	CRISPR spacer
gcccctctcccaccgggagaggggtt	Protospacer
.************ *** *******

7. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

acccctctcccacagggcgaggggta	CRISPR spacer
gcccctctcccaccgggagaggggtt	Protospacer
.************ *** *******

8. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

acccctctcccacagggcgaggggta	CRISPR spacer
acccctctcccgcagggagaggggct	Protospacer
***********.***** ******.

9. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

acccctctcccacagggcgaggggta	CRISPR spacer
gcccctctcccaccgggagaggggtt	Protospacer
.************ *** *******

10. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

acccctctcccacagggcgaggggta	CRISPR spacer
gcccctctcccaccgggagaggggtt	Protospacer
.************ *** *******

11. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to LR134127 (Klebsiella aerogenes strain NCTC10006 genome assembly, plasmid: 7) position: , mismatch: 4, identity: 0.846

acccctctcccacagggcgaggggta	CRISPR spacer
ggccctctcccacagggagaggggga	Protospacer
. *************** ****** *

12. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
gcccctctcccaccgggagagggggt	Protospacer
.************ *** ******

13. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
gcccctctcccaccgggagaggggct	Protospacer
.************ *** ******.

14. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP026279 (Klebsiella oxytoca strain KONIH2 plasmid pKOR-b08d, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

15. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP053606 (Escherichia coli strain NEB_Turbo plasmid F', complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
ggccctctcccacagggagagggaga	Protospacer
. *************** *****. *

16. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP053608 (Escherichia coli strain NEB5-alpha_F'Iq plasmid F'Iq, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
ggccctctcccacagggagagggaga	Protospacer
. *************** *****. *

17. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP026274 (Klebsiella oxytoca strain KONIH4 plasmid pKPC-4b66, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

18. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP029112 (Escherichia coli strain AR436 plasmid unnamed3, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

19. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP026205 (Escherichia coli strain ECONIH5 plasmid pKPC-e3ee, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

20. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP019841 (Enterobacter roggenkampii strain R11 plasmid pASM2, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

21. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP026172 (Klebsiella pneumoniae strain KPNIH50 plasmid pKPN-bbef, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

22. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP010365 (Enterobacter hormaechei subsp. oharae strain 34978 plasmid p34978-70.092kb, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

23. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP029833 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
tcccctctcccaccgggtgagggggg	Protospacer
 ************ ***.****** .

24. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP026398 (Klebsiella pneumoniae strain KPNIH48 plasmid pKPN-edaa, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

25. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP008843 (Klebsiella michiganensis strain M1 plasmid pKOXM1B, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

26. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP017452 (Klebsiella sp. LTGPAF-6F plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

27. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to AP017993 (Planktothrix agardhii NIES-204 plasmid plasmid2 DNA, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
gcccctctcccagatggcgaggggag	Protospacer
.*********** * ********* .

28. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_AP023206 (Escherichia coli strain TUM18781 plasmid pMTY18781-1_lncX3, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
ggccctctcccacagggagagggaga	Protospacer
. *************** *****. *

29. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_AP023206 (Escherichia coli strain TUM18781 plasmid pMTY18781-1_lncX3, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
ggccctctcccacagggagagggtga	Protospacer
. *************** *****  *

30. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP026232 (Citrobacter freundii complex sp. CFNIH4 plasmid pKPC-c9fd, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

31. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP014271 (Escherichia coli K-12 strain K-12 DHB4 plasmid F128-(DHB4), complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
ggccctctcccacagggagagggaga	Protospacer
. *************** *****. *

32. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP010382 (Enterobacter hormaechei subsp. steigerwaltii strain 34998 plasmid p34998-53.129kb, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

33. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP050068 (Klebsiella aerogenes strain 035 plasmid p35, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

34. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_KT935446 (Klebsiella pneumoniae strain Kp2964 plasmid 2964TF, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

35. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP043437 (Enterobacter sp. LU1 plasmid unnamed) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
ggccctctcccacagggagagggaga	Protospacer
. *************** *****. *

36. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP035215 (Klebsiella michiganensis strain M82255 plasmid pKOCBH-A, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

37. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP027617 (Klebsiella pneumoniae subsp. ozaenae strain AR_0096 plasmid unnamed5, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

38. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP026184 (Klebsiella pneumoniae strain KPNIH49 plasmid pKPN-af73, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

39. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP042547 (Klebsiella michiganensis strain C52 plasmid pC52_002, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

40. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP032208 (Klebsiella pneumoniae strain AR_0109 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

41. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP011646 (Klebsiella pneumoniae strain CAV1596 plasmid pKPC_CAV1596-97, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

42. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_AP023208 (Escherichia coli strain TUM18781 plasmid pMTY18781-3, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
gaccctctcccacagggagagggaga	Protospacer
. *************** *****. *

43. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_AP023208 (Escherichia coli strain TUM18781 plasmid pMTY18781-3, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
ggccctctcccacagggagagggaga	Protospacer
. *************** *****. *

44. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP018077 (Sulfitobacter sp. AM1-D1 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
gcccctctcccgcagggagaggggag	Protospacer
.**********.***** ****** .

45. spacer 11.1|3542129|26|NC_012918|CRISPRCasFinder matches to NZ_CP027125 (Escherichia coli strain AR_0374 plasmid unnamed3) position: , mismatch: 5, identity: 0.808

acccctctcccacagggcgaggggta	CRISPR spacer
aaccctctcccacagggagagggagc	Protospacer
* *************** *****.

46. spacer 3.1|370855|27|NC_012918|CRISPRCasFinder matches to MG592395 (Vibrio phage 1.009.O._10N.261.51.C9, partial genome) position: , mismatch: 6, identity: 0.778

catacctagctgtgcccctagctgtgc	CRISPR spacer
tgcccctagttgtgcccctagttgtgc	Protospacer
... *****.***********.*****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2070753 : 2079656

uncultured_Mediterranean_phage(66.67%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015837079.1\|2070753_2071863_+	SpoIID/LytB domain-containing protein	Q2XU88	Pseudomonas_phage	1.1e-18	30.1
WP_015837080.1\|2071864_2072890_+\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_015837081.1\|2072984_2074103_+\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	2.1e-89	46.7
WP_015837082.1\|2074255_2074573_+	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	7.6e-13	47.7
WP_015837083.1\|2074609_2076208_+	protein translocase subunit SecD	A0A1B1IVP7	uncultured_Mediterranean_phage	1.2e-05	24.6
WP_015837084.1\|2076218_2077124_+	protein translocase subunit SecF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.1e-43	40.4
WP_015837085.1\|2077133_2077706_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_015837086.1\|2077946_2079656_+	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	2.6e-67	30.3

DBSCAN-SWA_2

3925703 : 3935568

Aeropyrum_coil-shaped_virus(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015838608.1\|3925703_3927167_-	bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE	A0A0K0KVL9	Prochlorococcus_phage	1.3e-19	41.2
WP_015838609.1\|3927434_3928388_-	hypothetical protein	NA	NA	NA	NA
WP_015838610.1\|3928449_3929346_-	1-deoxy-D-xylulose-5-phosphate synthase	A0A0P0YNE1	Yellowstone_lake_phycodnavirus	1.0e-22	39.9
WP_015838611.1\|3929342_3930134_-	transketolase	G9E5U1	Micromonas_pusilla_virus	7.0e-15	31.2
WP_015838612.1\|3930137_3931001_-	NAD-dependent epimerase/dehydratase family protein	J7Q7J8	Aeropyrum_coil-shaped_virus	1.0e-11	27.5
WP_015838613.1\|3930997_3932347_-	lipopolysaccharide biosynthesis protein RfbH	A0A218MN59	uncultured_virus	1.2e-62	34.4
WP_043578938.1\|3932573_3933683_-	CDP-glucose 4,6-dehydratase	J7Q7J8	Aeropyrum_coil-shaped_virus	6.2e-17	28.0
WP_015838615.1\|3933724_3934498_-	glucose-1-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_015838616.1\|3934557_3935568_-	NAD-dependent epimerase	A0A2K9KZK0	Tupanvirus	5.1e-18	25.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_012918

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection