CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_013174	Jonesia denitrificans DSM 20603, complete sequence	4 crisprs	DEDDh,csa3,DinG,cas4,WYL,cas3	0	3	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_013174_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013174_1

57821-57909

Orphan

Consensus_repeat	Method
GGTGAGGGGGTGCGGGGCGAGGTGAGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013174_1

>merge|NC_013174|1|57821-57909|CRISPRCasFinder
GGTGAGGGGGTGCGGGGCGAGGTGAGGGGGTGCGGGGTGAGGTGAGGGTGGGGCGGTTGCGGGTGAGGGGGTGCGGGGTGAGGTGAGGG

>NC_013174|1|1|57821-57909|CRISPRCasFinder
GGTGAGGGGGTGCGGGGCGAGGTGAGGG	GGTGCGGGGTGAGGTGAGGGTGGGGCGGTTGCG
GGTGAGGGGGTGCGGGGTGAGGTGAGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013174.1\|WP_012805833.1\|58708_60238_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NC_013174.1\|WP_169304080.1\|67319_67490_-\|hypothetical-protein	unknown	unknown	unknown
NC_013174.1\|WP_143713202.1\|60439_61063_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013174.1\|WP_012805829.1\|54806_55928_-\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|226785
NC_013174.1\|WP_143713201.1\|47113_47626_+\|hypothetical-protein	unknown	unknown	unknown
NC_013174.1\|WP_012805830.1\|56063_57224_-\|TIGR04053-family-radical-SAM/SPASM-domain-containing-protein	unknown	unknown	gnl\|CDD\|274945
NC_013174.1\|WP_012805835.1\|61066_61987_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176112
NC_013174.1\|WP_012805843.1\|68693_71258_+\|AbfB-domain-containing-protein	unknown	unknown	gnl\|CDD\|377497
NC_013174.1\|WP_012805820.1\|43343_44336_-\|hypothetical-protein	unknown	unknown	unknown
NC_013174.1\|WP_012805824.1\|48159_48543_+\|hypothetical-protein	unknown	unknown	unknown
NC_013174.1\|WP_012805821.1\|44337_44967_-\|protein-tyrosine-phosphatase	unknown	unknown	gnl\|CDD\|319972
NC_013174.1\|WP_012805836.1\|62057_63200_+\|putative-sulfate-exporter-family-transporter	unknown	unknown	gnl\|CDD\|225411
NC_013174.1\|WP_012805837.1\|65969_66329_-\|hypothetical-protein	unknown	unknown	unknown
NC_013174.1\|WP_012805838.1\|66330_66912_-\|hypothetical-protein	unknown	unknown	unknown
NC_013174.1\|WP_012805832.1\|58073_58712_+\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NC_013174.1\|WP_012805826.1\|49133_51164_+\|hypothetical-protein	unknown	unknown	unknown
NC_013174.1\|WP_012805828.1\|52047_53307_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NC_013174.1\|WP_012805827.1\|51222_51864_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|188353
NC_013174.1\|WP_012805822.1\|44966_46391_-\|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl\|CDD\|349772
NC_013174.1\|WP_012805841.1\|67546_68113_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013174.1\|WP_012805822.1\|44966_46391_-\|polysaccharide-biosynthesis-tyrosine-autokinase	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	4.31909e-68
NC_013174.1\|WP_012805829.1\|54806_55928_-\|DNA-alkylation-repair-protein	gnl\|CDD\|226785	COG4335, COG4335, DNA alkylation repair enzyme [DNA replication, recombination, and repair].	1.12709e-33
NC_013174.1\|WP_012805830.1\|56063_57224_-\|TIGR04053-family-radical-SAM/SPASM-domain-containing-protein	gnl\|CDD\|274945	TIGR04053, sam_11, radical SAM protein, BA_1875 family. Members of this subfamily of the radical SAM domain superfamily show closer sequence relationships to peptide-modifying proteins of bacteriocin and PQQ biosynthesis than to other characterized radical SAM proteins. Within this subfamily, targets are likely to be diverse. [Unknown function, Enzymes of unknown specificity].	0
NC_013174.1\|WP_012805843.1\|68693_71258_+\|AbfB-domain-containing-protein	gnl\|CDD\|377497	pfam05270, AbfB, Alpha-L-arabinofuranosidase B (ABFB) domain. This family consists of several fungal alpha-L-arabinofuranosidase B proteins. L-Arabinose is a constituent of plant-cell-wall poly-saccharides. It is found in a polymeric form in L-arabinan, in which the backbone is formed by 1,5-a- linked l-arabinose residues that can be branched via 1,2-a- and 1,3-a-linked l-arabinofuranose side chains. AbfB hydrolyzes 1,5-a, 1,3-a and 1,2-a linkages in both oligosaccharides and polysaccharides, which contain terminal non-reducing l-arabinofuranoses in side chains.	2.8158e-45
NC_013174.1\|WP_012805833.1\|58708_60238_-\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	7.04384e-99
NC_013174.1\|WP_012805821.1\|44337_44967_-\|protein-tyrosine-phosphatase	gnl\|CDD\|319972	cd16344, LMWPAP, low molecular weight protein arginine phosphatase. Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.	1.64428e-34
NC_013174.1\|WP_012805836.1\|62057_63200_+\|putative-sulfate-exporter-family-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	7.53589e-57
NC_013174.1\|WP_012805832.1\|58073_58712_+\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	4.4452e-30
NC_013174.1\|WP_012805835.1\|61066_61987_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176112	cd08420, PBP2_CysL_like, C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold. CysL, also known as YwfK, is a regular of sulfur metabolism in Bacillus subtilis. Sulfur is required for the synthesis of proteins and essential cofactors in all living organism. Sulfur can be assimilated either from inorganic sources (sulfate and thiosulfate), or from organic sources (sulfate esters, sulfamates, and sulfonates). CysL activates the transcription of the cysJI operon encoding sulfite reductase, which reduces sulfite to sulfide. Both cysL mutant and cysJI mutant are unable to grow using sulfate or sulfite as the sulfur source. Like other LysR-type regulators, CysL also negatively regulates its own transcription. In Escherichia coli, three LysR-type activators are involved in the regulation of sulfur metabolism: CysB, Cbl and MetR. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.15577e-55
NC_013174.1\|WP_012805828.1\|52047_53307_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	4.67143e-25
NC_013174.1\|WP_012805827.1\|51222_51864_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|188353	TIGR03608, L_ocin_972_ABC, putative bacteriocin export ABC transporter, lactococcin 972 group. A gene pair with a fairly wide distribution consists of a polypeptide related to the lactococcin 972 (see TIGR01653) and multiple-membrane-spanning putative immunity protein (see TIGR01654). This model represents a small clade within the ABC transporters that regularly are found adjacent to these bacteriocin system gene pairs and are likely serve as export proteins. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate].	4.47629e-55
NC_013174.1\|WP_143713202.1\|60439_61063_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.99139e-12

>NC_013174.1|WP_012805830.1|56063_57224_-|TIGR04053-family-radical-SAM/SPASM-domain-containing-protein
MSVVDEHRSVRRLHHDAGDRPMITIWEVTRACALVCQHCRADAQHRRNPRELTTEQGKALLDNIASFGKPFPIVVMTGGDPFERDDLAELVAHGHAQGLHMALSPSVTPKMTPQRLRELRAAGASAMSLSLDGCCADTHDSFRGVPGVFDRTLDAAAWVREAGFRLQVNSTVTRKTVHELPRLLEMMVAMQASLWSVFFLVPTGRGQALEALSPSEVEDVLHWLADISDIIAVKTTEAPHYRRVVIQRRSGVDSSGRGELYRELTDAVAGLRASRTEAGALRRPRPPIEINSGRGFAFIDHVGDVYPSGFLPHQCGNVKDQAFTDIYRTSPILRSLRNPDGFDGKCGVCEFHDLCGGSRSHAYAVTGNALASDPTCVYQPAGWVTQ
>NC_013174.1|WP_012805829.1|54806_55928_-|DNA-alkylation-repair-protein
MPFADELLGRDVAASLLEHVALTRPGHEWPALSQAVDALDGLSLRERSDALRDALLADGPPAYSEFASLIRDAYARDEGFAGWLLWPVTNAVAHRAVSESPGAVNSAAFDDALDVLAMLTGRLTSEFAIRVLLLHDWERALRVVEGWTTSPDHHVRRLASEGTRPFLPWGVRIPALVERPTATLPVLDALYRDESEYVRRSVANHLNDVSRHHEDVVLDTARRWLAAPAPTTDALVRHALRTLVKRGHPQALELVGFPHVPAIEVENLSVAVTRVVVGEVLPFSAVLRNRGDVDARVRVDYVVFHRKANGSLTRKTFAIGVRDVLAGASVRVSKSHSFKPITTRRYHAGEHRIALQVNGVLTDPVMFDLVLND
>NC_013174.1|WP_012805828.1|52047_53307_-|Fic-family-protein
MAPLSGSPHDADQRPIARIAVPAVGWEEHLWIPGPGEGFSRSELRRQTGRYQSAIPAQFSTWQCVLDSAVAADVDEATRALVAFDERVVRRLGTEGAVLGPMSAILLRTESASSSQIEQLTTSARQLSLAELAHRSTPHARLVVGNVRAMEAALQLAGALDVSAILAMHSALLEHQRDMAEHAGRLREVVVWIGPGHAGPLRADFVAPQPHRVEGALADLVAFIGRVDIPPLVQIAIAHAQFETIHPFVDGNGRTGRALVNALLRSYGLVSHVTAPLSGGLLRRTTDYFEALQAFRRGDAGPIVAAFAQAARFAAHRGDLLVDALVTELHNSRSLLVGLRPQATAWRVLPLLVGQPVINNEYVMTALGVGKVTAQRAVDALVDRTVIRECTGQARHRVWQHDGFLGILDAFAAELKRAR
>NC_013174.1|WP_012805827.1|51222_51864_+|ATP-binding-cassette-domain-containing-protein
MRIDSHDLTVTIDGRTIIDHENVTCEPGAMTALTGPSGSGKTTLLHTLGLLLPAQTGRIVAGGRDVTAYNPRQRRRFWRDHAAFILQDYGIIDDDTVAFNVTMRARTKRTNPAMLAALDNTGLLGRENDTASHLSGGEKQRLALARAIYRNAHILYVDEPTASLDAANRDHVIALLANFAHTGATVIASTHDPALIAACDTQHVMGHQTLAGV
>NC_013174.1|WP_012805826.1|49133_51164_+|hypothetical-protein
MHKHVIAVTGVALYALLAVLAGVVTDFHDRFYPQALGVTDTITVDFTNSPWDRDAALTGMQQLNTDYDLGLYKLLPDLDSTGSQLYVDLTQPTITDPQPLNWFAADTPAHIVGTDTLTNSVIDGAYLITQPAQLGQAIAHLQALGVDVTHNTASPVDSITGLAATSGFAAPILAACALMGAITVYWLAAKARSRALRVLAGTPPWRIQLHDLGTLFAIIIGGATVVFTTATVTIGATRGWEFVPLYATILAVFSVLTLTATTLIALALSAISWPNTDLFARRTPAVATLRTAAKIVQIATLAAVIVYIGPAWTATTNAAATARQLDAWNQLSNEVHLSFAMLDDDMETIAPTIGTIIRDAEHDNQAALSYTIFNDTWGGNFGPYSAISIVNTRWLDLMTPSVASENTPTTDAPTNTPDTPATTMAGLEPAGEDAARIVTRELAPTLELWAPAGRTPSDILADSQLLTPTTNTAYPVAHGGTAGQLSFLNDVLIITVPTITGTFNDTNLTALASSANIILTDPATTHQRLIDAGLTRNNLTARGIDGSIQPLYVAEQGILEAQFATYLAQLLTLSIAALTIAFIVSVAINAVIASNLNARRDFPLRLAGHTWETVTRPRATTDLLIGVIITGIIVALQPADTLLITAGAATLGMIALYTAHPIAASIAFRHVTRRTL
>NC_013174.1|WP_012805824.1|48159_48543_+|hypothetical-protein
MAEDAPSSTRKIIVIVVGVVIAVAVALGGMGVVTGVLLRGETSAHPPCDQLPAVTEVEDALAAHPSLVQELEDLGDNVQVTVGEPCGTSTDQALVQVTYAEKSERDAIDSTLGQREGFGVPVYVVKN
>NC_013174.1|WP_143713201.1|47113_47626_+|hypothetical-protein
MTPVPPTVGDDERNRSNARSASARTVAATQQGDSMSDTGTTTPATRRTRTDRNATIIILIVATATIIGLSLIGTTMLGGILPARSTTHPPCTELPHVDDVKEALLTHSDLANDIESQGDTIRVAIATPCTANTTLALIEVSYTRDHELDAIDDLLTQRNGFGVPVHVTQR
>NC_013174.1|WP_012805822.1|44966_46391_-|polysaccharide-biosynthesis-tyrosine-autokinase
MELRDYIRILHKSWALIVAITLAGMGLGALATIFATPQYQSSTQLYVSVRSEGSQTGELVQGSTFARQIVASYVDVVRTGVVLDPVIEELNLQVSSGELAEFVTASSPLNTVLINISATSSDAQQAADIANAVGESFKDVVQTKLEATNASGQSPVQLTTTQAASVAQVPTSPNPKLNLALGLLVGLALGVGVAILRSVLDTRIHSLHDIEQITEKPLLGGIAFDPDTKTRPLIVHADPRNPRAESFRSLRTNLQFLNVGEGSRSFVITSAGPSEGKSTTSANLAISLAETGARVVLIEGDLRLPKVSEYMGVETGAGLTDVLIGKADLADVMHRWGRGQLYVLPAGRIPPNPSELLGSAAMDRVLAKLNDGFDYVLIDAPPVLLVTDAAVVGKKTSGVIMVVASSRTTKQGFGAAVRTLETAGTNILGVIVTMLPTKGPDSYGYGSYGYGHELEAIGAKEKRRGRFRGKRGSA
>NC_013174.1|WP_012805821.1|44337_44967_-|protein-tyrosine-phosphatase
MVGDVFSILTVCTGNICRSPLGEQLLAQQLADLADVRVASAGTGALVGHGMPDQSLAIARSLGVVDPESHVSRQLTPELLDESDVVFAMAREHRRAIVELNPRVSKRVFTLREFARLADATSDDDLRAEFAPGPFGGDVPSSPVERLRAGVAAVAAGRGMLPPLADPLGDDVVDPYRRSQDVYDQSTREIVPAVSSIVSLLRRALALEV
>NC_013174.1|WP_012805820.1|43343_44336_-|hypothetical-protein
MAISPRPPKPPAERSTKALVVVLVVFAVAVFAASALALSSTRGKSGDGLPTGPGHAQPTPTVTPDELPSSEPSESVEPEPEESGSEEPVEPVDVAPASRIIAAVDGALLIRATVASCESVTAVEFSSDGGASWVASDSVVETGSTQALRIIPTRADLVQLIALDEDCAPHLVRTNDQGESWLAPIGATGGWYLVPQDPGVLGGPNGLVDAPCEAVQLAATDARAAVLCADSSLVVTEDSGESWGDPVVVENLHAVGLSDGAYTVAVANVGECAGVQVANFNGSRVGDFGGCVERDVTAGDTALVRVDDEVFAWMGEDFVVSTDGGRSWPS
>NC_013174.1|WP_012805832.1|58073_58712_+|YitT-family-protein
MPAPPPSTAPSLTPARHKHTVIEDIFGLVAGVVVTSFALFLLRSTGAVTGGIAGLALAVEYWSGVSVSLLVVVLNVPFFAVALWQKGVRFTVRTLLAVGGLAVTTQFIGHVFTIDSINPVFGTLTGNLLAGLGMLMLFRHQASLGGVSITGLIIQERTGFKAGYTQLIFDACVVAISFVTLAPSMVALSILGAAVLNVVIVLNHRPDRYLGY
>NC_013174.1|WP_012805833.1|58708_60238_-|MFS-transporter
MTTASTIPAKATTRQWAALAALMIPVLLVSIDNTVLSFALPEISRSLHPTGTQLLWIVDAYPLILAGLLVAMGSLGDRVGRRKLLLIGAIGFGAVSLYAAFSTTPEHLITARALQGLFGATLMPSTLALLRNIFLDDVQRRLAIAIWASGFSAGAALGPIVGGWLLEHYWWGSVFLINAPVLAVLLIAAPLLIPESRDPQPGALDITSMVASVATMFTIVYGIKAAATGDALVAITAILTGSAIGWWFVRRQNRLTSPMLDMALFRNRLFSASVLTNLMAVVAMTGMLFYVAQYVQLVLGYSPFQSGLILLPGLVATVIAGLVAVRLSLHFPLRVLIPTGLALSASGFAVATQLGANTSVWLLIAAFALVGLGLGLAETLTNDAILGSVPPHKAGAASGISETAYELGALLGTAILGSILTAVYRTQFVIPPGVSDTDAEAARQTLGGAVDTAATLPDPLGTELLTHAKEAFALGADTTSFVGLLITATAATMMAIVLRTHKGLAGTPH
>NC_013174.1|WP_143713202.1|60439_61063_+|TetR-family-transcriptional-regulator
MKRTTLHTPPATHQGHRKHMDDNPTTAPTNTSHKRGSGRDRVLDAYINVLLTDGVAAATLDEVARRADISKGGLLHHFKSKDDLTQGLLDRFLTENAAEVAATLNSPDGPILGYLNGSTETGDTFPSLYMAVLRLAGTNNPLVDDALRTSQNAWLTGLQAHIDDPVTARLVHLVGDGLYLHTLLGGTRNPLDEAVIEFAHHIIRDRA
>NC_013174.1|WP_012805835.1|61066_61987_-|LysR-family-transcriptional-regulator
MTVRWPDLSVVELLVAVHDLGSVSAAARAVGMAQPNASRALAGLERDIGVTLVVRHPRGSTLTDAGVALVGQARSVLLAASSFVDTYAALRGNKPTTLRVAASMTVAEHLLPEWLVALRALNERVSVQVKAVNSSGVYDLVDAGSVDVGFVETPQRRTGLRSRVVTHDRLVVVAHPAHPWASRSSDRPVSLAELAATPLVVREPGSGTRRAFDDAMRALHPVAPALELESIGAIRSTVRAGGSPGVLSELAVAWSVAQRELVRVPVEGLTMRREIRAVWQGHRPSPAAEELIAASMRIGNPRSRAT
>NC_013174.1|WP_012805836.1|62057_63200_+|putative-sulfate-exporter-family-transporter
MPTLSPLLIAIILGATIANLWRIPDPTQHIIDVVGKYTLRAGIVLLGLQLHLADLVAAGPRVITTAVLVVTTGILSTLAIGRLLGIHRDLTLLIACGFSICGAAAVAAATATLTSQRGGDARQRGGDASERGGDTDERRPDVSHPGGDTGDSLPQHSALAIALVVLFGTLMIPLIPLLGHALGLTATQTALWAGASVHEIAQVVAIGDAVDPGTGNALHLAVVMKLARVLLLAVVLAVITMRHRRPVPAPAGGVLIQATAGSASSFTDTGSASSAASLSGAPLANNQSRTPRHTRVQPLIPTFVSGFIVMAALRTTGLLPDTVLTMAGHTQTVLLTIAMGALGTGVRIDKLMTVGGKPVVLAALATLIVGVVGLAGALTL
>NC_013174.1|WP_012805837.1|65969_66329_-|hypothetical-protein
MRHFLETFLFLLGGIALISRPMGSPWWVVLIVQVLISAAYYHTVRPLIEKASDSEKRSSVDIYRNNVGILLMAGVIGIYTPAAFVVGGLLIVISIVIAFRSFKYDEPVKDRGAKILRGF
>NC_013174.1|WP_012805838.1|66330_66912_-|hypothetical-protein
MRTRSYSRGAIAILLTFGLVSGGGIAASATTPPPTSKSIQDNESFEDDLADGFEVLFTEILQLDSNGTWKINEGELSKHPEIDRAKINEVALALTELERLEGSGKLSETRYQTQGKKEFGMCVLKGIIPGAGLVSIDWGKVYSYIKQKTWGKLSKYLAKHAAKIGAKELAKITPVGLASSVPIAAVGCAIWGY
>NC_013174.1|WP_169304080.1|67319_67490_-|hypothetical-protein
MRFIVRVLIALGFIALGISWITSPGTMGPGIGVVIVGVGLGVSSVYLYRHQNHPTK
>NC_013174.1|WP_012805841.1|67546_68113_-|hypothetical-protein
MTTPQTVPVVACLLGTLLLTSCSGQAAPAPENTPSPTPETTKTPTVVLDYEEEPEPEDEEEPPPPPIKPDRSLMEKMSCDAFEPEAPEDINVRFGNYTRSTQVKVGEGLIPGEEWWIVALELPADDSRDAGIRSFLTTEPGPPIPYVSWIEIGGDDPWGPVEWSRKKLVVAESALTKAHECLGVKPEG
>NC_013174.1|WP_012805843.1|68693_71258_+|AbfB-domain-containing-protein
MAKKLHTMTQGWRRQKTHASHPRKAHRGSSIGSFTLVCALLTGALTSVPAVSAVAAQAATSPGAGLLATAVNDTCVSGTWSTDPAVKMFPEQHTTEHFSFRWKSSEVSKTDVQAAGKALEEIWAQFMAEPIAFPEPHCDSATKRRVNVEIDPSYALTGGVTSEGAMGMWIGSGALKDRWGLAHELTHALQGSTKAFRDSPYVGWLWESHANWMTHQLPEFRTNPHCSELFANHTSLYYGSTRNNYCNWQFWEHLKVTYGSDTVQGLWANAPKQGAANYRDADPFSVLMEQQGWSLERLNDEFGLWAMKNVLWDYGTNTYRQAYGGYDNLTGDRTLRVTPMTPVEGVTGRYAVPFEAAPQRWGYNTVRLTPDSGATSVTVGFRGIVQDTAATSTLPGFANEPATVGSPHSGWRWGVVVEGADGKARYSELQKSVSGSVTVPLRSGDRGVYLTVLAAPTAQQKIAHNQPFYSIYRYPWTIDVAGAKPTEPTKPAGKKHPNGGGWVANGANVAATAFVGPNACVLGGTVSGQARIEDHATVMSGTVTDKAIVRGVSLIRGQATISGNAVVNTTFRGVGAFQSRITVSGNAQIHGDNELWPTSINSGVWYGFVDDNTLSSHPMRQLSAPVAEVTRRPSTADLAAVAPASTPAPTTEPTGEATTAPTAEPTVEPTAEPTAEPSSPPATPAPNPAPTNPTPTNPVPAPVPVPSPQPDAGDPVVGSTVTVASYNYPERSVRHQHYVGRIDATRDSEDWQWKKVTGLAPGGGGTVSFESVNFPGYFLVAVGRDVKLLRNDGTTGFARSATFTQVNGLADASALSFESLAAPGRYLRHYGFQLYVDPVFTPVARADATWRVMN

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Crispr_ID: NC_013174_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013174_2

1925892-1925971

Orphan

Consensus_repeat	Method
CTCACCCACGACGGCACCACCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013174_2

>merge|NC_013174|2|1925892-1925971|CRISPRCasFinder
CTCACCCACGACGGCACCACCACTCACAGTGCCCCCTCCACCTCCCCCGAACACACCTTCACCCACGACGGCACCACCAC

>NC_013174|2|2|1925892-1925971|CRISPRCasFinder
CTCACCCACGACGGCACCACCAC	TCACAGTGCCCCCTCCACCTCCCCCGAACACACC
TTCACCCACGACGGCACCACCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013174.1\|WP_015772041.1\|1932035_1934885_+\|glycoside-hydrolase-family-3-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|178629
NC_013174.1\|WP_015772032.1\|1917583_1918558_+\|acetylxylan-esterase	unknown	unknown	gnl\|CDD\|368448
NC_013174.1\|WP_015772043.1\|1935801_1936242_-\|DUF2550-domain-containing-protein	unknown	unknown	gnl\|CDD\|378486
NC_013174.1\|WP_015772027.1\|1909978_1912621_-\|beta-mannosidase	unknown	unknown	gnl\|CDD\|225789
NC_013174.1\|WP_015772040.1\|1930018_1931701_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270298
NC_013174.1\|WP_015772026.1\|1908996_1909884_-\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380491
NC_013174.1\|WP_015772046.1\|1938154_1939054_-\|F0F1-ATP-synthase-subunit-gamma	unknown	unknown	gnl\|CDD\|235535
NC_013174.1\|WP_049754464.1\|1922151_1924215_-\|beta-galactosidase	unknown	unknown	gnl\|CDD\|367090
NC_013174.1\|WP_015772042.1\|1935085_1935781_-\|endonuclease-NucS	unknown	unknown	gnl\|CDD\|235114
NC_013174.1\|WP_015772044.1\|1936258_1936537_-\|F0F1-ATP-synthase-subunit-epsilon	unknown	unknown	gnl\|CDD\|234796
NC_013174.1\|WP_015772030.1\|1914684_1915995_-\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NC_013174.1\|WP_015772031.1\|1916227_1917505_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NC_013174.1\|WP_015772039.1\|1928967_1929930_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_013174.1\|WP_015772037.1\|1926834_1927857_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_013174.1\|WP_015772029.1\|1913568_1914543_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_013174.1\|WP_015772034.1\|1919856_1922139_-\|alpha-xylosidase	unknown	unknown	gnl\|CDD\|236731
NC_013174.1\|WP_105597333.1\|1927957_1928800_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_013174.1\|WP_015772028.1\|1912750_1913572_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_013174.1\|WP_015772045.1\|1936580_1938062_-\|F0F1-ATP-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|236447
NC_013174.1\|WP_015772033.1\|1918567_1919824_+\|AGE-family-epimerase/isomerase	unknown	unknown	gnl\|CDD\|369267

Protein	Function_ID	Function_description	E-value
NC_013174.1\|WP_015772041.1\|1932035_1934885_+\|glycoside-hydrolase-family-3-C-terminal-domain-containing-protein	gnl\|CDD\|178629	PLN03080, PLN03080, Probable beta-xylosidase; Provisional.	1.43001e-42
NC_013174.1\|WP_015772032.1\|1917583_1918558_+\|acetylxylan-esterase	gnl\|CDD\|368448	pfam05448, AXE1, Acetyl xylan esterase (AXE1). This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyze the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan.	9.75741e-145
NC_013174.1\|WP_015772043.1\|1935801_1936242_-\|DUF2550-domain-containing-protein	gnl\|CDD\|378486	pfam10739, DUF2550, Protein of unknown function (DUF2550). This family is conserved in Corynebacterineae. The function is not known though most members are annotated as either secreted, or membrane, proteins.	2.28199e-38
NC_013174.1\|WP_015772027.1\|1909978_1912621_-\|beta-mannosidase	gnl\|CDD\|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	7.33921e-59
NC_013174.1\|WP_015772040.1\|1930018_1931701_-\|hypothetical-protein	gnl\|CDD\|270298	cd13580, PBP2_AlgQ_like_1, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	4.89313e-20
NC_013174.1\|WP_015772026.1\|1908996_1909884_-\|substrate-binding-domain-containing-protein	gnl\|CDD\|380491	cd06267, PBP1_LacI_sugar_binding-like, ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. Ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. In most cases, ligands are monosaccharide including lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. The LacI family of proteins consists of transcriptional regulators related to the lac repressor. In this case, the domain sugar binding changes the DNA binding activity of the repressor domain.	4.26748e-65
NC_013174.1\|WP_015772046.1\|1938154_1939054_-\|F0F1-ATP-synthase-subunit-gamma	gnl\|CDD\|235535	PRK05621, PRK05621, F0F1 ATP synthase subunit gamma; Validated.	2.7638e-131
NC_013174.1\|WP_049754464.1\|1922151_1924215_-\|beta-galactosidase	gnl\|CDD\|367090	pfam02449, Glyco_hydro_42, Beta-galactosidase. This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.	5.36677e-166
NC_013174.1\|WP_015772042.1\|1935085_1935781_-\|endonuclease-NucS	gnl\|CDD\|235114	PRK03298, PRK03298, endonuclease NucS.	6.63597e-162
NC_013174.1\|WP_015772044.1\|1936258_1936537_-\|F0F1-ATP-synthase-subunit-epsilon	gnl\|CDD\|234796	PRK00571, atpC, F0F1 ATP synthase subunit epsilon; Validated.	9.93319e-30
NC_013174.1\|WP_015772030.1\|1914684_1915995_-\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	8.23639e-36
NC_013174.1\|WP_015772031.1\|1916227_1917505_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	8.40529e-53
NC_013174.1\|WP_015772039.1\|1928967_1929930_-\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	5.14494e-97
NC_013174.1\|WP_015772037.1\|1926834_1927857_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	6.81367e-66
NC_013174.1\|WP_015772029.1\|1913568_1914543_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.51311e-75
NC_013174.1\|WP_015772034.1\|1919856_1922139_-\|alpha-xylosidase	gnl\|CDD\|236731	PRK10658, PRK10658, putative alpha-glucosidase; Provisional.	0
NC_013174.1\|WP_105597333.1\|1927957_1928800_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	6.34731e-58
NC_013174.1\|WP_015772028.1\|1912750_1913572_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.68836e-61
NC_013174.1\|WP_015772045.1\|1936580_1938062_-\|F0F1-ATP-synthase-subunit-beta	gnl\|CDD\|236447	PRK09280, PRK09280, F0F1 ATP synthase subunit beta; Validated.	0
NC_013174.1\|WP_015772033.1\|1918567_1919824_+\|AGE-family-epimerase/isomerase	gnl\|CDD\|369267	pfam07221, GlcNAc_2-epim, N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase). This family contains a number of eukaryotic and bacterial N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) enzymes (EC:5.3.1.8) approximately 500 residues long. This converts N-acyl-D-glucosamine to N-acyl-D-mannosamine.	5.57454e-97

>NC_013174.1|WP_049754464.1|1922151_1924215_-|beta-galactosidase
MVHRSGRPPLGHRIAYGGDYSPEQWDPDTWRDDIALMRTAGVTLITLGVFSWADLEPHPGTYTFDWLDDVINALHDAGIAVDLATPTASPPPWMGHLHPDTLARDRDGHTMHWGSRNHFSPASATYRDYCARIVTQLVTRYVHHPAVVMWHIGNEYGQLCYSDEAATRFRNWLLERYHSIDALNDAWGTSFWSQRYGSFDEVIPPRSAPYLINPGLNLDYQRFSSDLMRDCLREQRDIIRAADPHAVITTNFMGFFPLVNYPTWVNDLDIISDDIYPDPTNERSYHDTALAHTLMRSLANGKPWMLMEQAVSAVNWRPHNVPKPVHQTRREALTAVARGARGICYFQWRASAVGSERFHSAMLPHQGPNTPHFESVCALGRELEHLSTVLPHDDNLLPHVRVALVFTWENWWATREPALPTHQLDAYAVLRRWFTALHDLGVTVDIVPPGPHLTQYDVVAVPNLYQANDSDVEALRAVSEAGHTLILGPFSGIAHGDGHIHAGYFPVPLADLTGTHGQQWVPLGHATQFTLGVDSLPVPRYADHITLASATATAVASFPADAPHGLANAPAVVHNPATDVWTLAADLDSPALKALFTRILPPDLMPGRDLPDGVEVISGALHTLIVNHTDTAHTVALASLAGHNRRHPWVGQWHDALTMTSYDGSNTVHVPAYDAVFLVAANALDRI
>NC_013174.1|WP_015772034.1|1919856_1922139_-|alpha-xylosidase
MKFSHGYWLTRDGYTVLRPKDIDTVEERDGALVVYAPTAPIETRGDTLNRPLITTTFTAPIPDVIGVEIVHHKGRIDPGPHFALAAQEGAATITVADPHSGVPATITSGRLTATVSTDGPWHVDFSGQGRHLTSSMDRSVGVVSHTSGDRYVYEQLTMGVSENIFGLGERFGAFVKNGQVVDVWNEDGGTASEQAYKNVPFYLSDAGYGVFIDTPDHVSLEIGSEVVSRTQISVPGSRLRYFVIYGETPKDILSTYTALTGRPAAVPAWSYGTWLSTSFTTNYDEATVMSFIDGMIDRELPLSVFHFDCFWMRGFHWTDFVWHPDTFPDPQGMLNRIKAKDLHICVWINPYIAQRSHLFDEGMAKGYLVTEPDGSVWQWDMWQAGMALVDFTNPDATAWYVSHLKQLLDMGVDAFKTDFGERIPTNVVWHDGSDPQRMHNYYTLLFNKAVFDLLERERGTGEAVVFARSATAGGQQYPVHWGGDCESTFVAMAESLRGGLSLSLSGFGYWSHDIGGFEGTPDPAVFKRWVAFGFMSSHSRFHGSDSYRVPWAFDDESVAVTRLFSTLKMSLMPYLGRLGEEAATHGIPVMRPMLLEFPADRTARTIGTQYMLGDALLVAPVFDEHTAEFYVPEGTWTSLLTGDTYTGPRWYRKDMGFDDMPILARPGSVIPRGATTTRPDYPWAHDVTLHAYAFPDGHNTTVTIPASSATTQAARFTVWRDGDTLHARRDEGTGPWSLAIGGTSIRHHTTEKTASVTLAG
>NC_013174.1|WP_015772033.1|1918567_1919824_+|AGE-family-epimerase/isomerase
MIDHTGPALTSPDHHAWLRLQARGLLDFARKTMVAGRGAGWLTVDGQVDDTQAIHTWITARMVHAFSLGAILGDAHAREIAQEGLDALRSGPLRDSEHDGWFASIPVTAGAGEVDSTKSAYAHAFVVLAASSARVAGLSGAQELLTQGLAILEDRFFDAGTGLHVDEWDASWSVLDDYRGVNANMHAVEALLAAGDVTGDPVWHERALGIAKTVALQWAAPNGWRIPEHFSPSWEPLLEFNDDRRADPFKPYGATVGHGIEWARLLLHLDATFPGQHPWLQESARSLYSRAIADGWRRSTAGHMGFVYTTGWGGEPIVETRMHWVPAEALAAASALFTATSAPFYAKDYEQWLAHVERFFVDEAHGSWHHELDTANRPSGTVWPGKPDIYHAIGAFLTPTVPLSPTLASALAAQTSGR
>NC_013174.1|WP_015772032.1|1917583_1918558_+|acetylxylan-esterase
MAFFDLPLAELDTYRPEVRRPDDFTEFWDTTLAQARAFDLDVTLTKVDTGLDLVDVYDMEYSGFGGHRIKAWLTAPAGTDGPLPAVVEFVGYNGGRGLPHENLLWANAGYIHVKMDTRGQGSGWGNGGHTPDPVGSTPSVAGFMTRGITDPADYYYRRVYTDAVRAWEATVSLDRVDPQRTAIAGISQGGGITLAAAGLLGDKVAAVLPDVPFLCNFERATSITDADPFHEITAYLAVHRGEVDQVFTTLSYFDAVNFAPAASAPALFSVALMDMICPPSTVFSAFNHYGHDDKDIVVYPYNGHEGGQIHQVARQLPWLRSRLA
>NC_013174.1|WP_015772031.1|1916227_1917505_+|ROK-family-protein
MAATARTLNTTGSTSVVLDAIRAAGTISRVGIAQVTGLTGATVSTVVRKLLDAHLVIEIGRAESTGGKPRVLLELNPTARYAVGVHLDHGAITYAVTNLAGAPVARLARPGPGNASPADVVIRMADEINMLVESIGIARDKLLGLGLVSPGPLSSRAGMHLTPPFMRSWEDFPLDTQLADVAQLPVLLENDATAAAIGEYWSGGTQREESFAALYLGTGLGAGIVINGTAYRGTSGNAGEIGHTCANIDGPECWCGARGCFEALAGPAAVVNEAYSDPRIVTAAALDTLGDHTPITQRFAAIARASRMGDTPSRQLLERSARYVGVAAQSVANLLDVRMLVLTGSSFAAASHIYVPAIRDTLAASFFARDNHAVHVQLSQSAETAPAIGAAALVLQAQFVPERSTSLAAKVRSSPHVSELSTLSP
>NC_013174.1|WP_015772030.1|1914684_1915995_-|carbohydrate-ABC-transporter-substrate-binding-protein
MFPRTARKVAALTAAASLLALTACSSDSSGEGADGEVTLKVLTWRTDLVEDGTFDEYADRFNETYPDITVEFEGITDYEGEVKTRMSTENYGDVLGIVGTVQPAQLQDFFEPLGTVEEIEEDYRFVREKAYQGTVYGIPVVGNTQGIVYNRNVWQEAGLSDYPTTPEEFIEALKTIKDNTDTTPMYTNYAAGWTLTQWEAHRGEISADPNYVNSLLETDNPWVEGSDHYVIDSLLYDVVAEGLVEEDPTTTDWELSKDLIATGDVATMVLGSWAIVQMQQAAIDNGGEGTDIGYMPFPHQKDGTFYASVGGDYNLAINKHSKHKEEARQWIDWFNNHSGYAETQGGLSPLKDSVEPKVLEDFTLAGVQYVEQYPAPEGKEGLIDEIDNTAEIGLWQDMYRKRIVDAARGQGDETKEDIFADLNARWKAARAEVMGG
>NC_013174.1|WP_015772029.1|1913568_1914543_-|sugar-ABC-transporter-permease
MATHTEGGTPTRVAKTLSTSDATPGKPTNTRRTKKSGWGWSGTPYLFLLVPVVLLLALTYYPVINMFWYSVTDWDGLAKTKEFVGADNFITVFTKPEYFAVFKVSLYYFFASFVQMGIALYFATILSFNTRFKNFFKGVLFFPYLINGVAIGFIFLYFFRPDGTLDALMGILGLGEHTQHWLGNRDIANYSLAATSVWRYTGLNFVLFLGAIQSIPGEIYEAAEIDGANKWHQFLYIIAPSIRPIIGLSFILAISGSLSVFEIPFVMTGGANGTETFVIKTVDTAFKFNKVGQASAMAVVLLAIVLVVTWIQKRLVPEEKVNQS
>NC_013174.1|WP_015772028.1|1912750_1913572_-|carbohydrate-ABC-transporter-permease
MKQITATTLKYFSLIVACLVTLLPIGVIFMAAFKTKQEFRDTGPFDVPQSFNLDNFVTAFTKGQMVQGFVNTVIILAVAITGTIIIGTMAAYAIDRFRFRGRTLVLGGFLLATLVPAVTTQVATFQVINSLGLYNTRAAVMLLFMGTDIVSIYIFVQFMRSIDKSLDEAAVLDGANHLTIYGRIILPLLKPAIATVVIIKGIAIYNEFYIPFLYMPSRDLGVISTSLFRFKGPFGAQWEVISAGVIIVLIPTLLLFLFLQRYIYNGLTSGATK
>NC_013174.1|WP_015772027.1|1909978_1912621_-|beta-mannosidase
MTTSSVPTHWTLHLLDGPAPTHLDLTAVPATVPGTVHTDLLAAGLIDDPYLHMNEVSLEWMKHCSWRYDTTLTLDPPQPGERFELICEGIDTVASVYVNNTHIADTENQHRTYSFDVTDHITTATTLTVDFTSALARAREHITTLGDRPRAYDNPFNMVRKMACSFGWDWGPDLQTAGLWKPVTLHRWSHVRAHTPTIITTLDDHGTGHVTATVQLHWAPDATEPAELTLTLTTEPNKPAHTTTITVTPNQDRASVILDIPNAPVWWPAGYGDQPLCDTTLTLTSAGDTRFTTTKRVGFRTIEAHTTPDEHGTPFTLTINGQPIFIRGANWIPDDHLLTRITRDQLNTRITQARDANMNLLRVWGGGIYETDDFYDLCSEHGILVWQDFLLACAAYPEEEPFWSQLEAEARDNIARLTPYPALAVWNGGNENLWGFMDWGWQEELAGKSWGLGYYSDLFPRLLADIDPTRVYCDGSPYSPGFTAELESGVTAVHPNDQRHGTRHEWEVWNRQDYLTHLDYVPRFCSEFGHQGPPTWTTLTHAVAPENLHKDSDEFLLHQKAEDGNAKLDRGLAPHLPLPTDFADWNWATQLSQAHSVAFGVEHFRSRWPYTAGAIVWQLNDCWPVTSWAAIDSHGRNKPLYYGLAHAFAPRLITVKPVSDVVGGGEGAVATALGAGFGEDLPAGRDALGTPTVYVVNDTAHVWDGEATCELRSLDGTALASVSQPVRVAARSVESFPLPDDVRHPASPEASYVVVSVGDVRTFHYFTELKNLSLDSQAVTVAQVSPGSDSVVARGTTDTGASPVHVTLSAHSLAVDVALLVDRLDPQASVDDQLVTIQAGESHTFTVWTRLSALQVADRLAHGEQARFIVRSVNDLMRIS
>NC_013174.1|WP_015772026.1|1908996_1909884_-|substrate-binding-domain-containing-protein
MVNTVGHLDSGASDAALFPQGAIGLIRTAPRRMVTVEPFFMEFIAGVESELTPLGVSVLLAVVEDVDAECETYRRWASMGMVDAVLVVNIHANDPRPHLLHELGIPAVLVGQWSGPPEFPSVTANDAAAMTAVFSHLAEGGHRKIAHITGPAQYAHTQQRCEVLDVLARQRGIRVLTFEGDYSDTSGELLTTEALASDPPPTALIFDNDVMAVAGLHAVRSAGKKVPDDVAIVGWDDSPLCRLTEPPLTTATLDIFAMGQQAARSLVTSLKTGDVGAPTLMTATLNARGSTRVPQ
>NC_013174.1|WP_015772037.1|1926834_1927857_+|LacI-family-DNA-binding-transcriptional-regulator
MATIDDVAKAAGVSTSTVSYVLSGKRPISGPTRARVERAIRDLGYRPHAGARALASSRTNVIALVAPLRVAVNVNVIMEFVTGVVQAARTHNYDVLLLTQDDATGIDRVSSGSMVDAIIAMDIEEDDPRIPLLAQARQPAVLIGLPRDSSGLSCVDLDFFGAGTATVRHLAQLGHTSLAMLGAPEAVWKRHTSFWDRTLSGATYEANARDISLHAIACEASEVGARTAVATILSTHPDTTGLIVHNEAALPHVVAALRDRGLSIPDDMSIVAICPQHLATSQPQPLSSVTIPATAIGKVAVDMAIQRLNDPEQPAETRLLAAELTQRATTAAPHSAPVAP
>NC_013174.1|WP_105597333.1|1927957_1928800_-|carbohydrate-ABC-transporter-permease
MIGKFLILTVVVGLVAIPMWGIVVTSLSDAKTVQEAGGLVLFPKGITFASYAQLLSGGVVAQAAWVSVIVTVTGTVIATVVSALAAYGLSKPGTALHRPILFLFIITMFFSAGLIPTYLWISSLGLRNSLWALILPTCISAFNLLIMRNFFMGIDTGIIEAARIDGASEWKILFSIVMPMSKAVTAVIALFYGVGFWNAFFNAVLYIDDSSKWPLQMVLRQYVLQGQSIPGVDFTVAQGQLNSVSIKMAIMVLAVLPILIVYPFVQKHFTKGVIFGAIKG
>NC_013174.1|WP_015772039.1|1928967_1929930_-|sugar-ABC-transporter-permease
MTTTHHEPYAGDIPVRRMTLWQKIVRDRTFIIMTIPAVVLIIVFNYIPMIGNIGAFQDYNPYGGITGSPWVGLENFLDVLTSASFANALKNTLLITTFSLLFYFPVPIFLAVLMNSILSTKVRTVVQSVIYLPHFFSWVLVITIFQQFVGGASPLSQWMIRNGDAPLQIMTNPDTFIALVTTQAIWKDAGWGMIIFLAALSTVNPSLYEAAVVDGAGKMRRLWHITLPALRPVIVLLLILRLGDALNVGFEQMYLQRDAVGSGASDVLDTFVYFEGIQYSKWGFALAAGLMKGIVALLLVLGANKLAHRMGEAGVYQKAG
>NC_013174.1|WP_015772040.1|1930018_1931701_-|hypothetical-protein
MNTQREGSGLLNAPINRRSFLGLLAAGAATIGVPSLLASCAQNEPLPGDSTTGGGGTPTATSDGSIAPSYQPIQYVEPDFPSVNGTLPGYTSRPELVQAYDAPPGSGVTITAAAPTWSPIPDTTGQYFTAVNDAIGNTIDLNLLSGNDIWDIAQTRLADANSLPDWFALPTWTVSGNAKFGSEIAPAVFEDLTPHLTGDNVLTYPHLANIPTEAWMNSSWENKIYAIPMPGGALDMTYFYRKDLLADKGITEVAPTTIDDLFALYKEINDPGAGRYATLNPWTALTNIAFGVQSGWTVIDGKVVHRMETDNYFDCLEFVAKCYKENLVHPDDAAGRQTFLDGNVYFNGDGLGGWREMVASQVGVNDSFEMDAVVPFDYKGGDPVYWRAAPASFWSFIKKGIGEEKIAAILASADFLAAPYGTTEYDLVANGVEGVHYNLGDAGEPVKTELGNTEVVPSYMFLASPPGVAADFQYPGYVESYSAYSAAAGQYIQSSPFLGINVVVPDEYRDIEAGISDLETEVQRGRASIDVMRERVDQWRKDGGDALRDYYKNILDELPA
>NC_013174.1|WP_015772041.1|1932035_1934885_+|glycoside-hydrolase-family-3-C-terminal-domain-containing-protein
MTPSQSPQTAHDRAHHDATTIVDQLTITEKISLLHQAQPAIDHAGLAPFTTGTEALHGVAWLGEATTFPQPIGLAATWDTDLITRIGTAVATEVRAHHAINPTVSLNVWAPVVNPLRHPLWGRNEEGYSEDPHLTADCAIAYTQGLRGQHPTVWTTVPTLKHFLAYNNEIDRAVTSSDMRPRVLEEYEYPAFRRPLAAGTIGAVMPSYNLVNERPNHLAKDLLDTLRTWSPHPIAVVSDAAAPTNVVEGERYLPTHIESHAAMLHAGIDSFTDNDRNNQPTIDRLTAALDQGLITEEHITQAAYRLLYLRALTGEFRTENPYGHITANDINTPEHQALAREAAAKNVVILKNNETLPLRPTSLAVVGPFADHTVTDWYSGTPPYTVTLAQGLRDRFGDTTVTTHSGWDTIALWSPTARGYVTTTQQGTVDATARTLNDTTSWEMGEWGQGVITLRSRATTRYLGGANWILDAHATRIGGWVAQEAFQLHEHADHTISLLHRGSGKWVRVQHGSHLLVADTTDPAAAERFTRHTVESGALAVSALVHNANHVIVAVGNDPHLHGRETEDRPTLELPASAQQLWRIVTQAHTPTTLAIMSSYPYTLGPIADEADAIIWSSHAGQELGHGITDILVGDHEPWGRLAQEWVTDDTCPPHILNYDIIASQGTYWYNPCEPLFDFGAGLTYTTIAYSDLTLVTNTDGATTSAPTHATVTITNTGERTAHELVQVYTGQTWAPHVRSTPPARRLAGYTRATLTPGDSTTVTVPLNPEAFATWDTRTHAFVTGGDYDVWVGTSRTRRIVTHLSLDCDDAPLTLAATTLRAIDFDDPHRVRLSNTTLLSGDCVAPAHGFTQGSIDFHNVAFTNVTAVTAHLSGLGPGELGTVSLHCIDNDTPPLQWTTTHERPTCTDRYTWHAVNLPLLDTNPPTAHGTLRITVTGNVRVNTITFHAD
>NC_013174.1|WP_015772042.1|1935085_1935781_-|endonuclease-NucS
MRLVVAECQAHYSGRLAAHLPRARRLIVVKADGSVLLHSDGGSYKPLNWMSPPCSMAVREPDDLQKERGVTEVWRVQHSKADDRLDIEIFDVHHDSAHELGVDPGLVKDGVEAHLQRMLAEQIDLVGPGHTLIRREYPTAIGPVDILARDAHGATVAIEIKRRGDIDGVEQLTRYVELLNRDPLLTPVRGVFAAQEIKPQARVLAIDRGFTCLTLNYEEMKGYDDVDSRLF
>NC_013174.1|WP_015772043.1|1935801_1936242_-|DUF2550-domain-containing-protein
MGTIGWIIITLLVCVCGGALWGYLRLRRLSRQVGVFDCAWRAHSGPAVSRAGGGEHWAQGLAEYRTEELVWWRLYSLSLTPQERWSRQGFDITGRVPLDQADLPGLYLVQCRQGADSFELMMSAEAYHGLSSWTESGPPMTRGFVV
>NC_013174.1|WP_015772044.1|1936258_1936537_-|F0F1-ATP-synthase-subunit-epsilon
MAVLTVDVVAADRKVWSGDASLVSAPAADGEIGILAGHSPILSALTAGTVRVSANNGVTHKFTVSGGFLSVDQDVVTVVVDEATVVSDHDAK
>NC_013174.1|WP_015772045.1|1936580_1938062_-|F0F1-ATP-synthase-subunit-beta
MTATTVEATPGTSSGPAVGRIARVIGPVVDIEFPAEAIPEIYNALTVEIDLSAQGEGEKSFTMTLEVAQHLGDSLVRAIALKPTDGLVRGAAVTDTGAPISVPVGDVTKGHVFDVTGEVLNLKEGEKLEITERWPIHRKPPAFDQLESKTQMFETGIKSIDLLTPYVQGGKIGLFGGAGVGKTVLIQEMIYRVANNHNGVSVFAGVGERTREGNDLIDEMTESGVIKQTALVFGQMDEPPGTRLRVALSALTMAEYFRDVQKQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPNLADEMGMLQERITSTRGHSITSLQAIYVPADDYTDPAPATTFAHLDATTELSREIASRGLYPAIDPLASTSRILDPRYVGKEHYEVATQVKSILQRNKELQDIIAILGVDELSEEDKTIVSRARRIQQFLSQNTYMATQFTGVPGSTVPMSETIEAFKGIAEGKYDHIAEQAFFNIGGLEDLERNWSRIQKEYGL
>NC_013174.1|WP_015772046.1|1938154_1939054_-|F0F1-ATP-synthase-subunit-gamma
MAGNQRVYKARIKSTQSLKKIFRAMELIAASRIGKARARVAATVPYADAITRAVGAVATHSATDHPLTSERHDTNRVAVLVITADRGMAGAYSASALREAETLIERLTDEGKEVDLYVAGRRGVSFYQFRDREMVKTWTGASDSPTVDIAEDMADTLLSAFLADANKGGVSALHVVYTQFVNMVTQRPRVVRLLPLEVVDAPDESDEPVEAYPLYDFEPSAEEVLDALLPRYVRSRIFSFILEASASELAARQSAMHTATDNAQELIKTYTRLANSARQAEITQEISEIVSGADALAGS

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Crispr_ID: NC_013174_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013174_3

2415558-2415703

Orphan

Consensus_repeat	Method
TCATCAGACCCCGACGGGGACGGCTGGGGCTGGGAAAACAACCAGTCCTGCAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013174_3

>merge|NC_013174|3|2415558-2415703|CRISPRCasFinder
TCATCAGACCCCGACGGGGACGGCTGGGGCTGGGAAAACAACCAGTCCTGCATTGTGCCCACCCCAACGACCTACCCCACCTGCGCCAGCGCATCATCAGACCCCGACGGGGACGGCTGGGGCTGGGAAAACAACCAGTCCTGCAT

>NC_013174|3|3|2415558-2415703|CRISPRCasFinder
TCATCAGACCCCGACGGGGACGGCTGGGGCTGGGAAAACAACCAGTCCTGCAT	TGTGCCCACCCCAACGACCTACCCCACCTGCGCCAGCGCA
TCATCAGACCCCGACGGGGACGGCTGGGGCTGGGAAAACAACCAGTCCTGCAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_013174.1\|WP_015772499.1\|2422050_2422995_+\|mycothiol-synthase	unknown	unknown	gnl\|CDD\|132489
NC_013174.1\|WP_015772502.1\|2427408_2428029_-\|DUF47-family-protein	unknown	unknown	gnl\|CDD\|224310
NC_013174.1\|WP_041288512.1\|2425386_2426385_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239645
NC_013174.1\|WP_083775229.1\|2428549_2429161_-\|hypothetical-protein	unknown	unknown	unknown
NC_013174.1\|WP_015772491.1\|2411951_2412800_+\|HAD-IB-family-hydrolase	unknown	unknown	gnl\|CDD\|319796
NC_013174.1\|WP_105597323.1\|2417478_2419515_+\|acetate--CoA-ligase	unknown	unknown	gnl\|CDD\|234677
NC_013174.1\|WP_015772485.1\|2407300_2407726_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379164
NC_013174.1\|WP_015772498.1\|2421375_2421909_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|238075
NC_013174.1\|WP_015772487.1\|2408201_2408420_-\|DUF4244-domain-containing-protein	unknown	unknown	gnl\|CDD\|379429
NC_013174.1\|WP_015772494.1\|2415927_2417334_+\|cellulase-family-glycosylhydrolase	unknown	unknown	gnl\|CDD\|365907
NC_013174.1\|WP_015772496.1\|2419573_2420452_+\|hypothetical-protein	unknown	unknown	unknown
NC_013174.1\|WP_015772497.1\|2420455_2421379_-\|methyl-accepting-chemotaxis-sensory-transducer	unknown	unknown	gnl\|CDD\|214599
NC_013174.1\|WP_015772484.1\|2405829_2407140_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|372371
NC_013174.1\|WP_015772488.1\|2408567_2409818_-\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|227300
NC_013174.1\|WP_049754479.1\|2403287_2405819_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|274800
NC_013174.1\|WP_015772489.1\|2409808_2410969_-\|TadA-family-conjugal-transfer-associated-ATPase	unknown	unknown	gnl\|CDD\|200328
NC_013174.1\|WP_169304110.1\|2407722_2408076_-\|pilus-assembly-protein	unknown	unknown	gnl\|CDD\|377921
NC_013174.1\|WP_015772492.1\|2413376_2414246_+\|formate/nitrite-transporter-family-protein	unknown	unknown	gnl\|CDD\|376497
NC_013174.1\|WP_015772500.1\|2423010_2425311_+\|RNA-degradosome-polyphosphate-kinase	unknown	unknown	gnl\|CDD\|235469
NC_013174.1\|WP_015772490.1\|2410965_2411763_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274798

Protein	Function_ID	Function_description	E-value
NC_013174.1\|WP_015772499.1\|2422050_2422995_+\|mycothiol-synthase	gnl\|CDD\|132489	TIGR03448, mycothiol_MshD, mycothiol synthase. Members of this family are MshD, the acetyltransferase that catalyzes the final step of mycothiol biosynthesis in various members of the Actinomyctes, Mycothiol replaces glutathione in these species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	2.0031e-59
NC_013174.1\|WP_015772502.1\|2427408_2428029_-\|DUF47-family-protein	gnl\|CDD\|224310	COG1392, COG1392, Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism].	5.62599e-28
NC_013174.1\|WP_041288512.1\|2425386_2426385_+\|NUDIX-hydrolase	gnl\|CDD\|239645	cd03673, Ap6A_hydrolase, Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most preferred substrate, hydrolyzes to produce two ATP molecules, which is a novel hydrolysis mode for Ap6A. These results indicate that Ap6A hydrolase is a diadenosine polyphosphate hydrolase. It requires the presence of a divalent cation, such as Mn2+, Mg2+, Zn2+, and Co2+, for activity. Members of the Nudix superfamily are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site.	2.28286e-37
NC_013174.1\|WP_015772491.1\|2411951_2412800_+\|HAD-IB-family-hydrolase	gnl\|CDD\|319796	cd02612, HAD_PGPPase, phosphatidylglycerol-phosphate phosphatase, similar to Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C. This family includes Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C, PgpC (previously named yfhB) which catalyzes the dephosphorylation of phosphatidylglycerol-phosphate (PGP) to phosphatidylglycerol (PG). This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	6.68123e-54
NC_013174.1\|WP_105597323.1\|2417478_2419515_+\|acetate--CoA-ligase	gnl\|CDD\|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NC_013174.1\|WP_015772485.1\|2407300_2407726_-\|hypothetical-protein	gnl\|CDD\|379164	pfam13400, Tad, Putative Flp pilus-assembly TadE/G-like. This is an N-terminal domain on a family of putative Flp pilus-assembly proteins. The exact function is not known. The Flp-pilus biogenesis genes include the Tad genes, and some members of this family are putatively assigned as being TadG.	0.00096427
NC_013174.1\|WP_015772498.1\|2421375_2421909_-\|PAS-domain-containing-protein	gnl\|CDD\|238075	cd00130, PAS, PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.	2.68901e-09
NC_013174.1\|WP_015772487.1\|2408201_2408420_-\|DUF4244-domain-containing-protein	gnl\|CDD\|379429	pfam14029, DUF4244, Protein of unknown function (DUF4244). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 95 amino acids in length. There is a conserved EYA sequence motif.	1.39229e-14
NC_013174.1\|WP_015772494.1\|2415927_2417334_+\|cellulase-family-glycosylhydrolase	gnl\|CDD\|365907	pfam00150, Cellulase, Cellulase (glycosyl hydrolase family 5).	1.33634e-25
NC_013174.1\|WP_015772500.1\|2423010_2425311_+\|RNA-degradosome-polyphosphate-kinase	gnl\|CDD\|235469	PRK05443, PRK05443, polyphosphate kinase; Provisional.	0
NC_013174.1\|WP_015772497.1\|2420455_2421379_-\|methyl-accepting-chemotaxis-sensory-transducer	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	4.15085e-22
NC_013174.1\|WP_015772484.1\|2405829_2407140_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|372371	pfam12897, Aminotran_MocR, Alanine-glyoxylate amino-transferase. These proteins catalyze the reversible transfer of an amino group from the amino acid substrate to an acceptor alpha-keto acid. They require pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze this reaction. Trans-amination reactions are of central importance in amino acid metabolism and in links to carbohydrate and fat metabolism. This class of aminotransferases acts as dimers in a head-to-tail configuration.	0
NC_013174.1\|WP_015772488.1\|2408567_2409818_-\|type-II-secretion-system-F-family-protein	gnl\|CDD\|227300	COG4965, TadB, Flp pilus assembly protein TadB [Intracellular trafficking and secretion].	8.32426e-05
NC_013174.1\|WP_049754479.1\|2403287_2405819_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|274800	TIGR03817, DECH_helic, helicase/secretion neighborhood putative DEAH-box helicase. A conserved gene neighborhood widely spread in the Actinobacteria contains this uncharacterized DEAH-box family helicase encoded convergently towards an operon of genes for protein homologous to type II secretion and pilus formation proteins. The context suggests that this helicase may play a role in conjugal transfer of DNA.	0
NC_013174.1\|WP_015772489.1\|2409808_2410969_-\|TadA-family-conjugal-transfer-associated-ATPase	gnl\|CDD\|200328	TIGR03819, heli_sec_ATPase, helicase/secretion neighborhood ATPase. Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.	3.49672e-122
NC_013174.1\|WP_169304110.1\|2407722_2408076_-\|pilus-assembly-protein	gnl\|CDD\|377921	pfam07811, TadE, TadE-like protein. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in question is this family has a high proportion of hydrophobic amino acid residues.	2.13468e-05
NC_013174.1\|WP_015772492.1\|2413376_2414246_+\|formate/nitrite-transporter-family-protein	gnl\|CDD\|376497	pfam01226, Form_Nir_trans, Formate/nitrite transporter.	2.00709e-59
NC_013174.1\|WP_015772490.1\|2410965_2411763_-\|hypothetical-protein	gnl\|CDD\|274798	TIGR03815, CpaE_hom_Actino, helicase/secretion neighborhood CpaE-like protein. Members of this protein family belong to the MinD/ParA family of P-loop NTPases, and in particular show homology to the CpaE family of pilus assembly proteins (see ). Nearly all members are found, not only in a gene context consistent with pilus biogenesis or a pilus-like secretion apparatus, but also near a DEAD/DEAH-box helicase, suggesting an involvement in DNA transfer activity. The model describes a clade restricted to the Actinobacteria.	4.38032e-26

>NC_013174.1|WP_015772492.1|2413376_2414246_+|formate/nitrite-transporter-family-protein
MLSYPDALAYQVVAAQKKTTAATRIGSYTIASMLGGAYIGVAVVLMLTAAGPFFDNNSPATKLVSGLVFGVALSLVTVAGGELVTSNMMTLTQGLSQKAITINVWGRTLTVNFLGNLLGGIAFGTLVWLSGVTHKGTPAYAYMESILTAKATESIAELFFRAVLCNILVCLAIWSGIRLKSEVARLVMIFWCLLAFITSGFEHVVANMTTFTVGLLSGVTSVTIADFATNMVVVGAGNLVGGGAILGMAYVVLARAEGRAANEGTHTSHPSVLSPNEAAAHSQAAAKQN
>NC_013174.1|WP_015772491.1|2411951_2412800_+|HAD-IB-family-hydrolase
MAETTPTPHPATTPPHARGRARTAAFFDLDKTIIATSSAAAFSAPFYRGGLISRTAALRSAYAHFLFMMGGASESQTERLRANLSTLVTGWPVEQVTAIVADTLHQYIDPVVYAEALDLIDAHRSAGRDVIIVSASGSELVAPIASLLGADDYIATHMQIVDGHYTGLIDFYAYGPHKATAIEELAQVCGYDLTASYAYSDSITDAPMLTTVGHAYTVNPDRALRKLAQENHWGILTFRRPVALRRRGRRSALLGGMLLAAGITALFLAMRARRRARQSRSA
>NC_013174.1|WP_015772490.1|2410965_2411763_-|hypothetical-protein
MAGIVLAVTGAVGGCGASLLAASLAVHAAHVLRGLGRAQVGLVDANIWGAGLDVLLGMEEAPGVRWPQLANAHGEVDWSHLVTVLPAWLGVPLVSVDRTNPVEVPSAAFAGIAAGAARSGHVLIVDAPPAIVRHLGEVVTHHVVVVPRTVRGVAGAVSVLAAMGWTRHSGRGWQWGGPGPSPVVSLVAVTASGQSLTPGQVASHVGVSLAGEWPWVSQIGHAVEHGALASGLPSRLVKAGARISVVGGLDEALHRLNTTRPGGDQ
>NC_013174.1|WP_015772489.1|2409808_2410969_-|TadA-family-conjugal-transfer-associated-ATPase
MTPAAHKALWDDAREYATRHPVDSATPAWDIPTWVRTSGQVFGDQTQHETATHLRNDLYGAGPLQQFLDDPTVTDVLVHGDRLWVDQGHGPQEIAQSPLGQGQSREWAVRLAARAGTRLDDAHPITDAQLPDGSRFHAVLSPVSDADATMSIRVFRTRHATLHDLTRTGMIPRQWARACAQAVTHRASLLISGGTGAGKTTLLSALLSHVPHTERIITLEDSREIATNHPHVVALQAKPANVEGAGAVTLSNLVHASLRMRPDRLMLGECRGPEVRDLLMAFNTGHSGGAATIHANSVTDVPARLIALGALAGMDPVTTSLQAVSAVNAIVHVARTPAGHRYIKEWGVLRVGHDSLLTVAPFARWDGDTTPKDVPLPAGVERPAWW
>NC_013174.1|WP_015772488.1|2408567_2409818_-|type-II-secretion-system-F-family-protein
MVVILLLGGVIGVAAWWGNRHGVHRRVRVVAVGAVHAGTSRPHPLLVRVFPTWLGPRGNAPRVPLLPRVVSHLRSGQLPRTVWDSHGVLTVAGIPVVQALAHRLAEDDTAQRTVRVPPRDRCHSFQPADASAEQAARAVVAACRLSSVTGLSLATVLDTTAAALRRATDARSARTTATAGAEATARLLLFLPLFGLLMGYALGAQPLTWLTRTPLGWGSLIAAIVFLLAGRAWVARLLASATTTERAPTSRGPTSRGSRTRARAVANPPPSPPPIDVTITLDLLTTVMSAGHSIDSALDTVATHVPDLEVAQLGVVARLLLLGASWQRAWANAPARYAFLGEALADGWQRGSSVIPTLIATRDAWIAQEQADAHQRAQRLSSMIVVPVGVCYLPAFVLVGVVPTAVSLGVATFFGG
>NC_013174.1|WP_015772487.1|2408201_2408420_-|DUF4244-domain-containing-protein
MSHRLIHLPATLITRARTRLATTKEQGMATTEYAIVMVAAAAFAGVLVLILRSDSVRALLTGIVEGALATGG
>NC_013174.1|WP_169304110.1|2407722_2408076_-|pilus-assembly-protein
MPHQPPHNAHRETGSVTAEFAVLLPAVVLLILIVLAAALISRADISVHTAARTTARAVSVGLDPPATPHTTTHITRHGGWVTVHAQRHITFAGIPLPALSVDATATTLDEVALGAPQ
>NC_013174.1|WP_015772485.1|2407300_2407726_-|hypothetical-protein
MTTPQHPLTAPSTPQHHHKETGSITPLMIGIVAIWGLSLTALLGAHTITVTHTQLRTAADLAALAGANAHTNSTYLTTGLTTTTPISNPCALAADVAAQNMSETPHSVECKAGEHRGRASVTVTVQTTVLGVTLTQRATAG
>NC_013174.1|WP_015772484.1|2405829_2407140_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MPTQSGLAALPIADLRDRHAEYTTQYETLVARGLSLDLTRGKPAPEQLDLSNELLSLPGDTYTSPDGTDTRNYGGNKGLPALRAIFADLLNTHVDTLIAQGNSSLEVMHDLVLFSMLHGNNDSATPWVREERIRFLAPVPGYDRHFAVCAHLGIDLIPVPLGEDGPDVDTIRSLVAQDPSIKGIWCVPTYSNPTGVTYSEDVVNALVSMPTAAPDFRIWWDNAYAVHTLVDEAPKAIDILTLAADAGHPNRPYVIASTSKITFAGAGVAFLGTSQANLTWYLGHTGKRSIGPDKVNQLRHLLFLKDAQGVRDLMAKHRDILAPKFDAVLSILNERLGTLNVATWSQPEGGYFISLDVVPGTARRVIQLAAQAGIALTAAGSAFPGGNDPQDTNIRLAPSYPTLDAVREAMDGVATCVLLAAAEHALATHTATDIPE
>NC_013174.1|WP_049754479.1|2403287_2405819_+|DEAD/DEAH-box-helicase
MPRLDELVDALTAGGRRTDRMCHVEHRAARPAQHSAWPQWVHPAVRQALTVRGASSAWTHQATAAQAIHDGHHVALATSTGSGKSLAFWVPALTSIMSTRSGGSISRHRDRATALYLAPTKALAHDQLAALQKLLSAGGLDSVRVDAVDGDTSFDERRWVQAHGDIILTNPDFLHYALLPGHERWSRFLRGLEFLIIDEGHTYRGVFGAHVSLIVRRLQRLVAHYRGGRMPVVVVASATSAHPQQSAARLIGVSEDEVVAVTEDGSPSGRQTIVLWQPPQRESGFTQAPSDVVPGVVDELTGGWDHSVDDDLTGGADDLSGVITDAPVPSQPRRPATAEAVDLLADLTAHGARTLAFTRSRRAAEYLAVHTRDELLMSVPQLADSVAAYRGGFLPEERRALEAGVRSGSIRALASTNALEMGIDISGLDVVLIVGWPGTRMSLWQQAGRAGRAGSDGLVVFIAREDPLDTYVVSHPEAIFGAPLEATVFDPTNPYVLGGHLCAAAAELPVTEADLTLFGGCRAREVLDQLVDRGTLRRRPRGWYWVHDEPAAQFTSIRGDGQHVVQVVERSTGRLLGTVDAGAADGQVHDGAVYTHGGSTFVVAHYDVDNHVALVDQEVVAYSTWSRDVTSIEIVSTASERVVPAEVAGDPALVEWGFGQVNVHGQVTGFTRRRVPSGEVLGHESLDLPVRTLPTAAVWWSVSTAVLERAGLAVEEVPGALHAAEHAAIGLLPLLVTCDRWDLGGVSTAIHPDTERATVFVYDALPGGAGFAEQGFARGREWLLATRDAVARCQCVDGCPSCVQSPKCGNGNSPLSKEGAIRLLTVLLEVDVGELSPADAPFA
>NC_013174.1|WP_015772494.1|2415927_2417334_+|cellulase-family-glycosylhydrolase
MKIRHAVAAATALAATAALTLPVTVAHADPEPVGIHVKDGRIYEADGTELIMRGVNHAHTWYTGQTQSFADIGSLGANTVRTVLSNGVKWQRNDAADVANVIDLAKDAKLISMLEVHDTTGYGDQYADPPRSTLSEAADYWVDLKDVLIGQEDYVMINIGNEPYGNDAATNASYVAETKAAIATMRDAGLEHTIVVDAPSWGQDWQYLMRDNAQEIYDADPTGNTVFSVHMYQVFGTPASVTNYLEYFLDRDLPIIVGEFGWEHQNEVVAWEAILSESERLRTGYLGWSWSGNTEPYLDLALNFDKNNLSQWGEDLFFGPNGIQETATVASIFGGDPGEDPTDPGEEPTDPGEEPTDPGEEPTDPGEEPTDPSTGVCTAEYRTVGQWQGGFQGELTVTAASALSSWTLTWDAPGVTVTNSWGGQTTASGSTLTTVNEAWNGTLSAGATATVGFIGQGTPPAALEVACH
>NC_013174.1|WP_105597323.1|2417478_2419515_+|acetate--CoA-ligase
MQPEVLVPEHTQPATLDNLLQETRTFPPPAQFAAQANATAVLYDQAASDREGFWADQARTHVTWKTPFSTTLDWSDAPVAKWFADGTLNAAYNAVDRHVLAGNGDRVAFFFEGEPGDTRTITYNDLQRETSRAANALAALGVTRGDRVVIYLPLIPEAVIAMLACARVGAIHSVVFGGFSAEALRSRIADAQATVVITADGGFRRGSASALKPAVDEALSGHGSSVEHVLVVRRTGQDTTMVEHRDLWWHDALADANTAHEPAWVDAEHPLFILYTSGTTGAPKGIVHTTGGYLTQTAFTHHHVFDLKPEQDVYWCTADIGWVTGHSYVVYGPLVNGATQVLYEGTPDTPHQGRWWEIVEKYGVSILYTAPTAIRTFMKWGEDIPSSYNLSSLRVLGSVGESINPEAWMWYRRVIGGDQAPIVDTWWQTETGAIMISPLPGVTAAKPGSAQIPLPGIRADVVNDFGEPVGPGAGGYLVLSEPWPAMLRGIWGDRQRFVDTYWSRFSGIYFAGDGAKRDDDGDIWLLGRVDDVMNISGHRLSTMEIESALVSHPDVAEAAVVGASDDTTGQAVVAFVILRGHATERIGEQGHEEVVAALRAHVAKEIGPIAKPRDILVVPELPKTRSGKIMRRLLRDVAEHRVVGDATTLADSSVMDLISAKLAMPGSRAPSTTKERSR
>NC_013174.1|WP_015772496.1|2419573_2420452_+|hypothetical-protein
MSDHENTTFAQRIDTLSHTAKESEGDIKVTAWRELWRIVLPLERWFFIKDESETLSPIFLKDGDNVILPIFTDAARATQFADDFGGPDRVYASAPGSMLTAARQLTKNGVTLCVFNPQNEPFAVSPATLEQLAEGYISSGEGQIVGVQGNTPESQIDVLADFARKNPDDIKARGALWIHALLLDSWYLVPRGEGEAMQPFAVTGPDGPILMAFTEAKRAAEYATLRGLGDLDAVIAMTPTEIVEVFTRDSSVVTAVHIDPQHGSFFTQVDQLPQMLKIANDVAANQPDAEGV
>NC_013174.1|WP_015772497.1|2420455_2421379_-|methyl-accepting-chemotaxis-sensory-transducer
MTRNQLTTSERVELAAYRELFAEINRVTHHLNDGDLEQRWNTTPNAATLPNADTLRAQFNHFLDMVDVYLRESDGALAAAMSNRFERRFLHTGMRGAFARQATRVDTTTRELADAHTQLTASTHARTALAAHFEQEVLTHAENLSTVANELQTVSSHLSQDTRDVAERIGATAAQADNLTQHSEAMRDINSLIQQIAKQTRLLALNATIESKRVGEQGAGFAVVADEIRKLADQTSKASHGIEERLTESREQITSVAGALTDLDATIDRIDTDARQLEHKVAGADTSLMSSTHTLNAEVRRFLTELE
>NC_013174.1|WP_015772498.1|2421375_2421909_-|PAS-domain-containing-protein
MTDTRGQSAERVLAPNDIIVSKTDLQGRITYANDVFLTISDLTEDTALGQPHNIIRHPDMPAGVYQYMWDTIQAGQEIFAYVKNRATTGDYYWVYAYVTPSYDTRGTHIGYHSSRRAVTRDAITRVEQVYNAMKNAEHGLTGRARAHASLDVLTTTLERTGHTYSQWVWSLTHGDTP
>NC_013174.1|WP_015772499.1|2422050_2422995_+|mycothiol-synthase
MTTVLLTSTSGPLSDDAARSVRELVALETERLGVPPLSEQPLLNLRDPRARVVHIMDTQGGDVTGYAQLDVSREGGSLELTARCADRTQCVGALLNEAELIAQDHDVVVRPWVHGDDPDVTRVLAQRGYVPARTLLVLSRDLSLADTQALATPVVPEGFVCRRFDPISDADSLLAANSDAFSWHPEQGRLTHHDLSMRMKEPWFTPDHLHVVTPVSESARIVGFVWLKAEPHSRSIELYVLGVTEAAQGQGVGRFLTELATVTALNQGYPRLHLYVEADNTRALALYTQHGFAPMERHVNFTQPTGELGHEPPS
>NC_013174.1|WP_015772500.1|2423010_2425311_+|RNA-degradosome-polyphosphate-kinase
MTERDDRGPQLDTELPGIEDLETDLDAAIAEHIAEEPEANLPPAEPAPLPEGRFVDRELSWLAFNQRVLELAEDPGVPLLERVRFAAIFASNLDEYFMVRVAGLKRRIATGLAVTSASGLTPRQTLDAISTRATKLMQRHANVFHNDLQPALADEGITLVTWDDLSSQEQDRLHKFFRKQIFPVLTPLAVDPAHPFPYISGLSLNLAVLLRNPTTDKEHFARVKVPPLLPRFIAVDAKGRPSAPDTHTVDPTSFVPLEDIIAHHLHYLFPGMEVVEYHTFRVTRNEDVEVEEDDAENLLKAMEKELLRRRFGPPVRLEVAKGITGRIRDLLVRELRITHDEVYTLQAPLDLTGLNLIADLDRADLHYPAFVPTTSRQLADVESATPSDIFGAIRRSDVLLHHPYDSFSTSVQTFLEQAAADPHVLAIKQTLYRTSGDSPIVDALIDAAEAGKQVLALVEIKARFDEQNNISWARKLERAGVHVVYGIVGLKTHCKLSLVVRQEADGLRRYCHVGTGNYNPKTARLYTDLGLLTCDPDVGQDLTRLFNQLSGYAPQSKFHRLLVAPRTVRTGLIARIDRETQAAQQGLPAWIKIKVNSIVDEQTIDALYRASQAGVSVDLVVRGICALRPGVPGLSENIRVRSILGRFLEHARIYAFANSLGADPNTPVLPGSAGIPGLPDVFIGSADLMHRNLIRRVEALVSITHERHVNGLITLIDRSMSDEVSTWHLEPDDTWTRRHRGNNDIPLSDIQQELITRQRQRLTLGH
>NC_013174.1|WP_041288512.1|2425386_2426385_+|NUDIX-hydrolase
MAAEPKTTAPVIECAGALVWRIKDEDLQVLLIHRPRYNDWSWPKGKRDPGEALPCTAVREVKEETGKDIILGIPLPGLQYITPEGDLKRVHYWAAHTTKKSHGALAARAPIGEVNPDEVDDTQWMSVKDAAKALTRAADRAPLDALIHAHTEGRLDSHVVAIARHGKAVSRASWGGKEGDRPLTPLGQGQSWALVPVLSAFGVISVVTSRWARCAQTMRPYEQAARVHAKELDTLTEASHERDPDLVVRAMTEIITDNRPTVLCSHRPVLPTVFAAMKKASATKGIGNAFPESDPYLTTGEVLIAHVVPRVDGKGKMGGTIVGVERVRPEVM
>NC_013174.1|WP_015772502.1|2427408_2428029_-|DUF47-family-protein
MRLRITPRDTSFFDLLAELASHLVVGSQLLGEILGASKADRKAIGKKISEAENAADDVTHTIMRQLNSTFVTPLDRDDIAGLASALDDCMDHMEEAADLIVLYKLEEIPRKVSDQVSVLQRCSELTAEAMPHLRQMNDLSEYWVEINRLENQADKAHRKLLAQMFDEVQDPIQLMKIKEVVETLETAADAFEKVANMVETIALKES
>NC_013174.1|WP_083775229.1|2428549_2429161_-|hypothetical-protein
MFDHTHTASIPGGEDPGNYGEVAHMTANVIVTQAHADATPDIIDRLVRLVEREGIDTVAALWSTSPPNTLPGALWRLYLLREWVRDSPDLTTTHYRLGRDTAHVSHAIAGPIDPPTPTDIAALADTVLSGAFTGALDVALARASAFCQVVSVGASLGADSSDSSGRLDTGATSRQLTHIARRFHELFTDFQEASSLARAGLLD

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Crispr_ID: NC_013174_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013174_4

2598241-2598342

Orphan

Consensus_repeat	Method
CGCATCGGCAGGTGAGGGAACAACACCGCCACCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013174_4

>merge|NC_013174|4|2598241-2598342|CRISPRCasFinder
CGCATCGGCAGGTGAGGGAACAACACCGCCACCGGCAACCTGATCGTGGGGCTGGGACTGGGGGCGCGCATCGGCAGGTGAGGGAACAACACCGCCACCGGC

>NC_013174|4|4|2598241-2598342|CRISPRCasFinder
CGCATCGGCAGGTGAGGGAACAACACCGCCACCGGC	AACCTGATCGTGGGGCTGGGACTGGGGGCG
CGCATCGGCAGGTGAGGGAACAACACCGCCACCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013174.1\|WP_169304113.1\|2592846_2595060_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_013174.1\|WP_015772663.1\|2595707_2596730_-\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|236406
NC_013174.1\|WP_015772674.1\|2604187_2606785_-\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529
NC_013174.1\|WP_015772660.1\|2592487_2592823_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_013174.1\|WP_015772664.1\|2596869_2597331_-\|hypothetical-protein	unknown	unknown	unknown
NC_013174.1\|WP_015772656.1\|2587245_2588556_-\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|234856
NC_013174.1\|WP_015772668.1\|2599401_2599977_-\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
NC_013174.1\|WP_083775232.1\|2602631_2603486_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_013174.1\|WP_015772655.1\|2586286_2587249_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NC_013174.1\|WP_015772675.1\|2607025_2607967_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237864
NC_013174.1\|WP_015772658.1\|2589943_2590984_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_013174.1\|WP_015772673.1\|2603472_2604096_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_013174.1\|WP_015772676.1\|2607963_2608971_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225176
NC_013174.1\|WP_015772662.1\|2595220_2595601_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_013174.1\|WP_015772669.1\|2599996_2600806_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NC_013174.1\|WP_015772670.1\|2600815_2601442_-\|hypothetical-protein	unknown	unknown	unknown
NC_013174.1\|WP_015772667.1\|2598495_2599269_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319832
NC_013174.1\|WP_015772657.1\|2588890_2589856_+\|acyl-CoA-desaturase	unknown	unknown	gnl\|CDD\|239583
NC_013174.1\|WP_015772671.1\|2601490_2602285_+\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197320
NC_013174.1\|WP_015772659.1\|2590958_2592245_-\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904

Protein	Function_ID	Function_description	E-value
NC_013174.1\|WP_169304113.1\|2592846_2595060_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	4.50951e-40
NC_013174.1\|WP_015772663.1\|2595707_2596730_-\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|236406	PRK09197, PRK09197, fructose-bisphosphate aldolase; Provisional.	0
NC_013174.1\|WP_015772674.1\|2604187_2606785_-\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NC_013174.1\|WP_015772660.1\|2592487_2592823_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	6.67073e-13
NC_013174.1\|WP_015772656.1\|2587245_2588556_-\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NC_013174.1\|WP_015772668.1\|2599401_2599977_-\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	9.51198e-66
NC_013174.1\|WP_015772676.1\|2607963_2608971_+\|alpha/beta-hydrolase	gnl\|CDD\|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	8.74143e-34
NC_013174.1\|WP_015772655.1\|2586286_2587249_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	1.63285e-163
NC_013174.1\|WP_015772675.1\|2607025_2607967_+\|hypothetical-protein	gnl\|CDD\|237864	PRK14950, PRK14950, DNA polymerase III subunits gamma and tau; Provisional.	6.60223e-05
NC_013174.1\|WP_015772658.1\|2589943_2590984_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.24537e-64
NC_013174.1\|WP_015772673.1\|2603472_2604096_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.74368e-11
NC_013174.1\|WP_015772662.1\|2595220_2595601_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.13696e-13
NC_013174.1\|WP_015772669.1\|2599996_2600806_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	1.24213e-72
NC_013174.1\|WP_083775232.1\|2602631_2603486_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	3.69947e-28
NC_013174.1\|WP_015772667.1\|2598495_2599269_+\|HAD-family-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.96718e-121
NC_013174.1\|WP_015772657.1\|2588890_2589856_+\|acyl-CoA-desaturase	gnl\|CDD\|239583	cd03506, Delta6-FADS-like, The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases are required for the synthesis of highly unsaturated fatty acids (HUFAs), which are mainly esterified into phospholipids and contribute to maintaining membrane fluidity. While HUFAs may be required for cold tolerance in bacteria, plants and fish, the primary role of HUFAs in mammals is cell signaling. These enzymes are described as front-end desaturases because they introduce a double bond between the pre-exiting double bond and the carboxyl (front) end of the fatty acid. Various substrates are involved, with both acyl-coenzyme A (CoA) and acyl-lipid desaturases present in this CD. Acyl-lipid desaturases are localized in the membranes of cyanobacterial thylakoid, plant endoplasmic reticulum (ER), and plastid; and acyl-CoA desaturases are present in ER membrane. ER-bound plant acyl-lipid desaturases and acyl-CoA desaturases require cytochrome b5 as an electron donor. Most of the eukaryotic desaturase domains have an adjacent N-terminal cytochrome b5-like domain. This domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain the residues: HXXXH, HXX(X)HH, and Q/HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homolog, stearoyl CoA desaturase.	9.04814e-58
NC_013174.1\|WP_015772671.1\|2601490_2602285_+\|exodeoxyribonuclease-III	gnl\|CDD\|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	2.23824e-111
NC_013174.1\|WP_015772659.1\|2590958_2592245_-\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0

>NC_013174.1|WP_015772664.1|2596869_2597331_-|hypothetical-protein
MTLFSTKVYKNTTVYDRSYTAKWNTKKKTFTVTASAVPGYVKPVHTLSKQIRTNAPFTSVTVSAANEKRIRTFNKNADRSGQRATVCEPLTSKKAACAYMYLGNNAIDVLTFNIAPRGKGYIIGTVSSDRYTPEELGLSGQSDVTELLGELTK
>NC_013174.1|WP_015772663.1|2595707_2596730_-|class-II-fructose-bisphosphate-aldolase
MPIATPEVYAEMIDRAKAGKFAYPAVNITSSSTITAALQGFAEAESDGIIQVSVGGAEFASGSTIKDRIAGSLSLAAYAAEVAKNYPVNIAIHTDHCTKKNLDSWVRPLLALEAEQVKAGKNPTFQSHMFDGSDIPLEENLIIAAELLELSQAARTILEIEVGVVGGEEDGHEAEINDKLYTTAEDGLKTIDALGAGEKGRYLTALTFGNVHGVYKPGAVKLRPSLLADIQREVGAKIGKENPFDLVFHGGSGSTAAEIAEAVDNGVIKMNIDTDTQYAYSRPVADHFFKNYDGVLKVDGEVGNKKAYDPRAWYKLAEGGMAARIIEAAQQLRSAGNKMK
>NC_013174.1|WP_015772662.1|2595220_2595601_+|STAS-domain-containing-protein
MTQTHKLNSLSSCDEVSYHMHGRQAVIVLRGEIDIDIQSCFARVAEMLHPHTDDIVVDAEGVEFIDSSGIAVLGQIAHNHPGRVTLLNAPPTMLFILEVTQLIDVIRLESGHLTKYLDSAVPTHAE
>NC_013174.1|WP_169304113.1|2592846_2595060_-|SpoIIE-family-protein-phosphatase
MNVHISGELAPEIEDSPVPYVLLKGEFSPPVVEASNRAFRELLGVDSTPSGQTFNDLKITLRRQDKRTGNIETWGPQASRRGSGGGSAVSTRHIPSPAEALWRHGEEVRSHQVLRGEVWTADLVHSEGSWGIVQAVIAPLATSPGASQRWVVQFLPLTGFDEAFGYAAPAAERALDALSQISELLSAESQTSPLAEISRILEATFPVDWVGFFLEGKGLEYSETIRPPARPRHRGDYRSRDVDGSGAVDPVLQVLVGKRIDPVLLPCGFDAEESTRTRAFMDHLDDVWDVHGFTPRGPLIIQAILGRSGVLGAIVMACPETNELGEPFEVPDLGTESLKVLSAVSRRIGTTLDNARLYKHEHELAEALQQSMLPTQVDVAGLDVWTYYAPSNEHARVGGDWYDILYVDEQTVGVVVGDVVGHDLEAAAAMGQLRSITRSYAFDRVSASKVIERVDRLVDGLDIPRQASMVYGRLRESKSRGTWQLEYARAGHLPPILVRDGEAILLDDAGGGLIGFLPRPRSSATIRLRPGDVVLFYTDGLIERRDRSMQAGVKELQEFAQTVPQCAADQWGELLLRALADAPEDDVALVVVRIPVRDELSVQGMDLARSYRATFPGDPSSVARARHVIMRLCDEWDKPHTTFAELVMSELAANAVLHGYGQFALRVYDLGEDLRIEVEDQNPIGPIRMDGHGDRYGGYGVKIVDRLANWGWSPKGAGKVVWAHVPVTQERGAPEVR
>NC_013174.1|WP_015772660.1|2592487_2592823_+|STAS-domain-containing-protein
MFEIATTPMATTVVISGDLDLASRDQFLEVAARLTSLRRSLLTIDMCDVRFMDSTGAAFLISLAETGQRRGWLTVLRGSSDAHRFVLDICGATHLFRFDTEHYCHHTASPA
>NC_013174.1|WP_015772659.1|2590958_2592245_-|adenylosuccinate-synthase
MPAVVVVGAQWGDEGKGKATDQLGAQVDYVVKFNGGNNAGHTVVINGDKYALHLLPSGILSPGVTPVIGNGVVIDIEVLYQELDALEARGVDTSTLLISGSAHVIPSYNRTMDKVTERFLGKRRIGTTGRGIGPSYSDKINRVGIRVWDLFDEKILRAKVEGALQQKNQLLVKVYNRREVLIDEIVEELLALAERLRPMVCDTSLELNNALDEGKTVLFEGGQATMLDIDHGTYPFVTSSNATAGGVCTGSGVGPTRIDRVIGVIKAYTTRVGEGPFPTELFDDMGEYLQKKGGEFGVTTGRARRCGWYDAVIARYASRVNGLTDLVLTKLDVLTGIEKIPVCVAYDVDGVRYDEMPTDQSAFHHATPILEYFDGWTEDIYGVQSFDDLPVNAQQYVLALESMSGCRISSIGTGPGREHTIIRHALVD
>NC_013174.1|WP_015772658.1|2589943_2590984_+|LacI-family-DNA-binding-transcriptional-regulator
MNTQRRVTAKDVARRAGVSQSTVSYVLNDTPNQTISDDTKKRVRLAAEELNYMPSAAARTLRRGTSDTVLVIIRDAQIGEILAQILEGVVHTLDPHGLNVIYRRQRPGKSALDLCHELMPAAVANFAALTKDEIGRIQEWNIPVLSISFDDTAPTDAGDTVILAQTAIGRTHVAHLHEQGHTRIAYAAPDIRDVEDYDTWRLTGVRDECVTRGLPRPPVIHTPYNLDGGMEAAREILALDPPVTAISAFNDEVATILLAAFHRLNVPIPERLSIIGVDDLPLSPFTYPSLTTINIHAYDIGTHVAQLVLRTVRPDLNLPAPPPVGELTLITRDSVSAPVSPPGHAE
>NC_013174.1|WP_015772657.1|2588890_2589856_+|acyl-CoA-desaturase
MLSILGLSIVGLAVGSFFLGDSWFQLLIAAALGIVLTQVSFITHEAAHRQVFTSGPANDTMGRILANAVVGISYQWWMNKHTRHHANPNTVGKDPDIERDTISFTPDDASAQRGFSGWLTRRQGYLFFPLLTLEGLNLHWHSLRYLVTAPSVKNRTTELVTVLARLSIYVALVFLHLPVGMGCAFLGVQLAVFGVYMGGSFAPNHKGMPLIDRVTTVDFFSRQVLTSRNILGRTPLANLWLTMAYGGLNYQVEHHLFPNMPRMHLPAAAKIVQQYCADLNVPYTVASVRQSYSQVISYLNRVGLSGRDPFDCPMVTQFRPS
>NC_013174.1|WP_015772656.1|2587245_2588556_-|phosphoribosylamine--glycine-ligase
MKILVLGSGAREHAIVHSLAHEHTRTGRNPHDLHAAPGNPGIGQLATRHDVDANDPDAVTALARQLGVDLVMVGPEAPLVAGVADAIRAASIPVFGPSAKAAQLEGSKAFAKEVMAAAGVPTARPYVCTTMNDVTDALAAVGSDHPYVVKDDGLAAGKGVVVTTDRDAALAHAQACLEGRDAAHAKVVIEEYLDGPEVSVFVVSDGTTVRALSPAQDFKRVGEGDTGPNTGGMGAYTPLDWAPAGLVDEVITSIAQPTVNEMARRGTPFVGILYVGLALTSTGTRVVEFNVRFGDPETQSVLARLATPLSEVLLAGATGTLANLPELAWHDDVSVTVVLAAHNYPDTPTTGDAITGIDKAEHVPGVHVLHAGTTINQAGTLVSQGGRVLSVVSRGTTLTQARERAYEAIAHINLNGSHYRRDIAAQAERGEITVAP
>NC_013174.1|WP_015772655.1|2586286_2587249_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MSGLDTTAQHLPGWRHVYSGKVRDLYEPDTDALGGPHPLGDVVLVVASDRVSAYDHVLSPGIPGKGIVLTQLSVWWFEQLAEIVGNHLVSLEVSVTPTDGLIPAAVDGRAMICRRLTMFPIECVVRGYLTGSGLVEYRDNSTVCGVPLPAGLTDGSRLEVPIFTPAAKAEVGEHDENITFEDTAQRIGWAAAEILRDHTLAVYTHAEGIAREHGVILADTKLEFGTDPVTGEILLGDEVLTPDSSRFWDALMWAPGGAQPSFDKQFIRDWLTSSESGWDRSSDTPPPALPQHVVAATQERYLEAYTRITGKSLTLPTDAQ
>NC_013174.1|WP_015772667.1|2598495_2599269_+|HAD-family-hydrolase
MTRTIESWLTDMDGVLVHEGHAIPGAPEFIARLREKERPFLILTNNSIFTPRDLRARLSASGIEVDESNIWTSALATAKFCADQMPGGSAYAIGEAGLTTALYEAGYTLTDSSPDYVVLGETRTYSFEAITKAVRLILDGARFICTNPDPTGPSQEGPMPATGAAAAMITKATKREPYFVGKPNPMMFRSALNRIDAHSETTAMIGDRMDTDVVAGIEAGLQTYLVLTGSTAPHEVDGYPFRPSEVRDSIADLIDLI
>NC_013174.1|WP_015772668.1|2599401_2599977_-|orotate-phosphoribosyltransferase
MTETLSPTPREQLAALIRELAVVHGTVTLSSGATADYYVDLRRVTLHHRAAPLIGHVLLDTLEEAGFGPADVDAAGGLTLGADPIATALLHAAASRGLDLDAFVVRKAAKAHGMQRQIEGPDISGRRVVVVEDTTTTGGSPIAAIEACRAAGADVVAVATIVDRATGAKEKIEALGVPYLSLFGLTDLGLA
>NC_013174.1|WP_015772669.1|2599996_2600806_-|SDR-family-NAD(P)-dependent-oxidoreductase
MATALITGATAGIGLEFAWQLAASRHNLVLVARDAHRLDAVAQQLNSVAGVHVDVLPADLGTREGIDSVVQRLSDRDRPINLLVNNAGYAINTRFLDSEIDDQAEALTVMVEAVMRLSHAAAKVMRQRGRGLIINVSSVAALTASGTYSAHKAWVRSFTEGLAVELSGTGASAMALCPGFVHTEFHERAGIDYSGFPEVAWLSAEELVREALADARRGAVLSTPSLRYKGASGLLRILPRFVVRALQVRGAVASTAAGRRNPITTPSQT
>NC_013174.1|WP_015772670.1|2600815_2601442_-|hypothetical-protein
MSALTIIYVPGLFDRTRFLLSAQWAALRLWRPLGARVRMFTVGWAGEIAWEERLAALIAMIDARHERGETVALVGASAGASAVLGAFSARSDVVAGAVLICGKIHRPHIIPEPIFDVNDVFEDALDDIAEFVAELDPQERDRVMSLRAAVDGVVFPSDTMIPGAHNVRMRVVGHIPGIAWGLVLHGHMILRFLRGCAARRLPEPEHTD
>NC_013174.1|WP_015772671.1|2601490_2602285_+|exodeoxyribonuclease-III
MRLASWNINSIRARTDRALAVLERHDIDVLALQETKCKDEQFPVAAFEEAGYEVAHVGVNQWNGVALISRVGLDDVHRAFPGQPGFGEDPVVEARAVGAICGGVRVWSLYVPNGREIDHPHYHYKLQWLHQLKNSAQQWTADDPAAQVALVGDWNVAPRDTDVWDREFFEGKTHVTDPERAAFAAFGDIGYTEVSRVHVPEDVYTYWDYQQLRFPKNQGMRIDFAWCSPALTKRVTGVEIDRNERKGKGASDHVPVILDISESL
>NC_013174.1|WP_083775232.1|2602631_2603486_+|C40-family-peptidase
MTRTQRVAPEHALKPGTTRKRRPTLTIAALTGSLILAGIVAPATAQATPTSTAATTVATAPVAAATPLNTAVKKAPSIKVSTSKKKWAKGSTPAKVGTKVVVAGKAATGKAQFYVGKKRVATKTLKNGKATYRLSKKLSAKKHTVTVRYLPTGSAKNISTTGSKATRVQVKASKTDKVLAIAKAQVGVKYRSGGTSPSRGFDCSGFTQYVYKKAGVKKLPRTSSAQKRAGKRVSRSAARPGDLVWSPGHVAIYAGNGKIIDAPRPGKKIAVRKMWQSNPVFIRL
>NC_013174.1|WP_015772673.1|2603472_2604096_-|TetR/AcrR-family-transcriptional-regulator
MARYARGKSTREEIIKEAMIVFAKNGYYEASLRDISARVGISHPGLLHHFPSKSDLLLAVLDARDAEDVRITLPLLEQGYDLVDAIVELAERNMERPGMVSLFAKLSAEATDPAHPAHEYFSERYRRTLEGYTLYFEELRRQEKLSPTLDPAEVAKALVALMDGLQVVWLYGWRSGLPDRHVDMPRIVREFLSFTGRGNTPETVTTG
>NC_013174.1|WP_015772674.1|2604187_2606785_-|ATP-dependent-chaperone-ClpB
MEPKNTSMTQQALSDAIQSATAASHPQVDALHLLSALLDQTDGFASELLRLTGVNTQTLGADVRRALVALPTVSGTSVTQPTASHDLGLALQRARAEADKAGDTYVSTEHLLLGIAHTQCTAGDLLTKAGATYEALTQQLPSLQQGKDRNSANPEGTYKALEKYGIDLTAAARESSLDPVIGRDTEIRRVIQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQRIVKNDVPESLRNKRLISLDLTAMVAGAKYRGDFEERLKSVLDEIKSSDGEIVTFIDELHTVVGAGGGSEGAMDAGNMLKPMLARGELRLIGATTLDEYRENIEKDPALERRFQQVYVDEPSVEDTIAILRGLKPRYEAHHGVEISDGAVIAAATLSHRYITGRRMPDKAIDLIDEAASRLRMEMDSSPVEIDTLERSIERLTMEEIALRDSDAASAPTRLDEVRAQLADAQEQLLVLNARWERERGGLNKAGELRKQLDDLHAQAERAQLDGDLETASRILYGEIPAVQRALDDAVTAENITAETDTRERLVGERVDAHEIAEVVEAWTGIPVGRLLQEESDKLLHMEERIGGRLIGQEEAVASVSDAVRRSRAGVSDPNRPTGSFLFLGPTGVGKTELAKALAEFLFDDERAMVRIDMSEYGEKHSVARLVGAPPGYVGYDEGGQLTEAIRRRPYSVVLLDEVEKAHPEVFDILLQVLDDGRLTDGQGRTVDFRSTILVLTSNIGSQFLIDPITDAQAKRESVMAAVRAHFKPEFLNRLDDVVMFDALTLPQLTKIVDMQVAEIERRVADRRMSVTVSDDARRWLAETGFDPVYGARPLRRLVQREIGDRLARLILAGEAVEGSVIAVSAGPDGLIVDVRPV
>NC_013174.1|WP_015772675.1|2607025_2607967_+|hypothetical-protein
MRTSPHTTAIARIVVAAVTLVALTGCVRVHTDLTLNNDNTASGEIIFAVSDEFAESLGMTPEEVADALLTTGDGAADQGIGAGATSEEPYQEDSYTGTRYVFEATPINDTANDEALSIIREDDVFVVSGVFEDQLSDPELAGLEDPMLSSMDVRFSITFPGDVIETNGDIDGKTVTWTYTPGEDLVMEARGEATGSGLDILSTPEGGLPGWLIGLLIALSLVLVAIVVVIIVVISRSRRNQAHNDGQVPPPGASPLPQEAGTIYPQEPPAPPTSGSEPPAPPAPTPPAATVDPAHNPTPTPRPDASPTDHDKP
>NC_013174.1|WP_015772676.1|2607963_2608971_+|alpha/beta-hydrolase
MSTTPSASPRAPEFHDDNSGVWRRDVLGDSWVARTLHVGCDEEGAVNATLVRRTAGPRHRRAVLAIHGFVDYFFQEHQAEFFESLGFDFYAIDLRKYGRSLRPEQTPNYVTELADYRRELEAAQHIIREEEGHDLFVVLGHSTGGLIASLWANVNDSIDGVILNSPWFDLNKPQIVTWFVDLVMPLVARCHPRRPVGALAPHYGRALHRDSGGQWDYDLTWKPHDGFPVRAAWLMAIRRGHHAIRRGLHLPMPVLVLSSTRSGSATRFHEELLTTDSVLRVEHILDGAERLGRDVTVAQVDEGAHDLSLSQSEKARQAYYDHIAAWLTDRGFLAD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_013174_2	2.1\|1925915\|34\|NC_013174\|CRISPRCasFinder	1925915-1925948	34	NZ_CP015446	Streptomyces sp. S8 plasmid unnamed, complete sequence	46058-46091	7	0.794
NC_013174_4	4.1\|2598277\|30\|NC_013174\|CRISPRCasFinder	2598277-2598306	30	NZ_AP014579	Burkholderia sp. RPE67 plasmid p1, complete sequence	179626-179655	7	0.767
NC_013174_4	4.1\|2598277\|30\|NC_013174\|CRISPRCasFinder	2598277-2598306	30	NC_016626	Burkholderia sp. YI23 plasmid byi_1p, complete sequence	1485873-1485902	7	0.767
NC_013174_4	4.1\|2598277\|30\|NC_013174\|CRISPRCasFinder	2598277-2598306	30	LC589952	Enterobacter phage vB_EkoM5VN DNA, complete genome	51650-51679	8	0.733
NC_013174_4	4.1\|2598277\|30\|NC_013174\|CRISPRCasFinder	2598277-2598306	30	KX431560	Cronobacter phage vB_CsaM_leN, complete genome	2787-2816	8	0.733
NC_013174_4	4.1\|2598277\|30\|NC_013174\|CRISPRCasFinder	2598277-2598306	30	NC_048646	Cronobacter phage vB_CsaM_leE, complete genome	2787-2816	8	0.733
NC_013174_4	4.1\|2598277\|30\|NC_013174\|CRISPRCasFinder	2598277-2598306	30	MN508621	UNVERIFIED: Enterobacter phage EC-W1, complete genome	18717-18746	8	0.733
NC_013174_4	4.1\|2598277\|30\|NC_013174\|CRISPRCasFinder	2598277-2598306	30	MT341500	Enterobacter phage EBPL, complete genome	5018-5047	8	0.733
NC_013174_4	4.1\|2598277\|30\|NC_013174\|CRISPRCasFinder	2598277-2598306	30	JN882287	Cronobacter phage vB_CsaM_GAP161, complete genome	1888-1917	8	0.733
NC_013174_4	4.1\|2598277\|30\|NC_013174\|CRISPRCasFinder	2598277-2598306	30	NC_048645	Cronobacter phage vB_CsaM_leB, complete genome	2787-2816	8	0.733
NC_013174_4	4.1\|2598277\|30\|NC_013174\|CRISPRCasFinder	2598277-2598306	30	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	10228-10257	8	0.733
NC_013174_4	4.1\|2598277\|30\|NC_013174\|CRISPRCasFinder	2598277-2598306	30	MN508623	UNVERIFIED: Enterobacter phage EC-F1, complete genome	127401-127430	8	0.733
NC_013174_4	4.1\|2598277\|30\|NC_013174\|CRISPRCasFinder	2598277-2598306	30	MN508624	UNVERIFIED: Enterobacter phage EC-F2, complete genome	127957-127986	8	0.733
NC_013174_1	1.1\|57849\|33\|NC_013174\|CRISPRCasFinder	57849-57881	33	NZ_CP034939	Pectobacterium odoriferum strain JK2.1 plasmid p.Jk2_1, complete sequence	92904-92936	10	0.697
NC_013174_1	1.1\|57849\|33\|NC_013174\|CRISPRCasFinder	57849-57881	33	NZ_CP027261	Pectobacterium parmentieri strain IFB5427 plasmid pPAR01, complete sequence	59101-59133	10	0.697

1. spacer 2.1|1925915|34|NC_013174|CRISPRCasFinder matches to NZ_CP015446 (Streptomyces sp. S8 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.794

-tcacagtgccccctccacctcccccgaacacacc	CRISPR spacer
gtcaccg-gccacctccacctcccccgcacaccgg	Protospacer
 **** * *** *************** ****

2. spacer 4.1|2598277|30|NC_013174|CRISPRCasFinder matches to NZ_AP014579 (Burkholderia sp. RPE67 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.767

aacctgatcgtggggctgggactgggggcg	CRISPR spacer
cgcttcttcatggggctgggactgggcgcg	Protospacer
 .*.*  **.**************** ***

3. spacer 4.1|2598277|30|NC_013174|CRISPRCasFinder matches to NC_016626 (Burkholderia sp. YI23 plasmid byi_1p, complete sequence) position: , mismatch: 7, identity: 0.767

aacctgatcgtggggctgggactgggggcg	CRISPR spacer
cgcttcttcatggggctgggactgggcgcg	Protospacer
 .*.*  **.**************** ***

4. spacer 4.1|2598277|30|NC_013174|CRISPRCasFinder matches to LC589952 (Enterobacter phage vB_EkoM5VN DNA, complete genome) position: , mismatch: 8, identity: 0.733

aacctgatcgtggggctgggactgggggcg	CRISPR spacer
gaactgatcggggcgctgggactgggtagt	Protospacer
.* ******* ** ************ .

5. spacer 4.1|2598277|30|NC_013174|CRISPRCasFinder matches to KX431560 (Cronobacter phage vB_CsaM_leN, complete genome) position: , mismatch: 8, identity: 0.733

aacctgatcgtggggctgggactgggggcg	CRISPR spacer
gaactgatcggggcgctgggactgggtagc	Protospacer
.* ******* ** ************ .

6. spacer 4.1|2598277|30|NC_013174|CRISPRCasFinder matches to NC_048646 (Cronobacter phage vB_CsaM_leE, complete genome) position: , mismatch: 8, identity: 0.733

aacctgatcgtggggctgggactgggggcg	CRISPR spacer
gaactgatcggggcgctgggactgggtagc	Protospacer
.* ******* ** ************ .

7. spacer 4.1|2598277|30|NC_013174|CRISPRCasFinder matches to MN508621 (UNVERIFIED: Enterobacter phage EC-W1, complete genome) position: , mismatch: 8, identity: 0.733

aacctgatcgtggggctgggactgggggcg	CRISPR spacer
gaactgatcggggcgctgggactgggtagc	Protospacer
.* ******* ** ************ .

8. spacer 4.1|2598277|30|NC_013174|CRISPRCasFinder matches to MT341500 (Enterobacter phage EBPL, complete genome) position: , mismatch: 8, identity: 0.733

aacctgatcgtggggctgggactgggggcg	CRISPR spacer
gaactgatcggggcgctgggactgggtagt	Protospacer
.* ******* ** ************ .

9. spacer 4.1|2598277|30|NC_013174|CRISPRCasFinder matches to JN882287 (Cronobacter phage vB_CsaM_GAP161, complete genome) position: , mismatch: 8, identity: 0.733

aacctgatcgtggggctgggactgggggcg	CRISPR spacer
gaactgatcggggcgctgggactgggtagt	Protospacer
.* ******* ** ************ .

10. spacer 4.1|2598277|30|NC_013174|CRISPRCasFinder matches to NC_048645 (Cronobacter phage vB_CsaM_leB, complete genome) position: , mismatch: 8, identity: 0.733

aacctgatcgtggggctgggactgggggcg	CRISPR spacer
gaactgatcggggcgctgggactgggtagc	Protospacer
.* ******* ** ************ .

11. spacer 4.1|2598277|30|NC_013174|CRISPRCasFinder matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 8, identity: 0.733

aacctgatcgtggggctgggactgggggcg	CRISPR spacer
gacctgatccaggggctgggactgctcggc	Protospacer
.********  *************   *

12. spacer 4.1|2598277|30|NC_013174|CRISPRCasFinder matches to MN508623 (UNVERIFIED: Enterobacter phage EC-F1, complete genome) position: , mismatch: 8, identity: 0.733

aacctgatcgtggggctgggactgggggcg	CRISPR spacer
gaactgatcggggcgctgggactgggtagt	Protospacer
.* ******* ** ************ .

13. spacer 4.1|2598277|30|NC_013174|CRISPRCasFinder matches to MN508624 (UNVERIFIED: Enterobacter phage EC-F2, complete genome) position: , mismatch: 8, identity: 0.733

aacctgatcgtggggctgggactgggggcg	CRISPR spacer
gaactgatcggggcgctgggactgggtagt	Protospacer
.* ******* ** ************ .

14. spacer 1.1|57849|33|NC_013174|CRISPRCasFinder matches to NZ_CP034939 (Pectobacterium odoriferum strain JK2.1 plasmid p.Jk2_1, complete sequence) position: , mismatch: 10, identity: 0.697

ggtgcggggtgaggtgagggtggggcggttgcg	CRISPR spacer
tggatttggggaggtgagggtggggcgattggt	Protospacer
 * ..  ** *****************.***

15. spacer 1.1|57849|33|NC_013174|CRISPRCasFinder matches to NZ_CP027261 (Pectobacterium parmentieri strain IFB5427 plasmid pPAR01, complete sequence) position: , mismatch: 10, identity: 0.697

ggtgcggggtgaggtgagggtggggcggttgcg	CRISPR spacer
tggatttggggaggtgagggtggggcgattggt	Protospacer
 * ..  ** *****************.***

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2328490 : 2348364

Mycobacterium_phage(22.22%)

terminase,capsid,portal

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015772398.1\|2328490_2329225_+	phage antirepressor Ant	A0A0C5AEJ9	Bacteriophage	1.1e-65	49.8
WP_015772399.1\|2329221_2329413_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015772401.1\|2329514_2330573_+	hypothetical protein	NA	NA	NA	NA
WP_015772403.1\|2330697_2330856_+	hypothetical protein	NA	NA	NA	NA
WP_015772405.1\|2330940_2331225_+	hypothetical protein	NA	NA	NA	NA
WP_015772406.1\|2331214_2331892_+	YqaJ viral recombinase family protein	G9FH00	Rhodococcus_phage	2.1e-60	46.9
WP_015772407.1\|2331891_2332425_+	hypothetical protein	G9FH01	Rhodococcus_phage	9.5e-32	54.8
WP_015772410.1\|2332739_2332991_+	glutaredoxin family protein	NA	NA	NA	NA
WP_015772411.1\|2332992_2333406_+	single-stranded DNA-binding protein	V5RAD6	Arthrobacter_phage	7.9e-18	47.7
WP_015772412.1\|2333523_2333877_+	hypothetical protein	NA	NA	NA	NA
WP_041288482.1\|2334077_2334338_+	hypothetical protein	A0A159B6S1	Tsukamurella_phage	7.4e-22	63.3
WP_015772414.1\|2334327_2334723_+	hypothetical protein	A0A1S5S8Q1	Streptococcus_phage	8.1e-12	35.1
WP_015772415.1\|2334841_2335027_+	hypothetical protein	NA	NA	NA	NA
WP_015772416.1\|2335023_2335389_+	WhiB family transcriptional regulator	A0A2P1N2X5	Mycobacterium_phage	1.6e-06	38.2
WP_015772417.1\|2335385_2335637_+	DUF2188 domain-containing protein	NA	NA	NA	NA
WP_015772418.1\|2335626_2336583_+	hypothetical protein	A0A2K9VH47	Gordonia_phage	1.6e-34	34.9
WP_015772419.1\|2336579_2336939_+	hypothetical protein	NA	NA	NA	NA
WP_015772420.1\|2336935_2338219_+	AAA family ATPase	C7BGG1	Burkholderia_phage	5.8e-43	30.8
WP_015772421.1\|2338215_2338419_+	hypothetical protein	NA	NA	NA	NA
WP_015772423.1\|2338833_2339115_+	hypothetical protein	NA	NA	NA	NA
WP_015772424.1\|2339111_2339492_+	DUF4326 domain-containing protein	A0A142K9N0	Gordonia_phage	3.4e-23	40.8
WP_169304109.1\|2339488_2339629_+	hypothetical protein	NA	NA	NA	NA
WP_015772425.1\|2339697_2340252_+	hypothetical protein	NA	NA	NA	NA
WP_015772426.1\|2340564_2340867_+	HNH endonuclease	A0A2H5BLP3	Streptomyces_phage	1.8e-11	45.5
WP_041287916.1\|2341309_2341699_+	HNH endonuclease	A0A1C9M094	Mycobacterium_phage	2.7e-12	35.8
WP_015772428.1\|2341942_2342512_+	bifunctional DNA primase/polymerase	A0A2P1CIA7	Actinomyces_phage	1.1e-33	47.8
WP_015772429.1\|2342560_2342929_+	hypothetical protein	A0A097EWH3	Mycobacterium_phage	1.4e-18	42.9
WP_015772430.1\|2342912_2344694_+\|terminase	terminase	I3NLA4	Bifidobacterium_phage	5.0e-202	59.5
WP_015772431.1\|2344690_2346025_+\|portal	phage portal protein	I3NLA3	Bifidobacterium_phage	1.0e-87	39.6
WP_015772432.1\|2346024_2346795_+	hypothetical protein	I3NLA2	Bifidobacterium_phage	2.1e-32	36.7
WP_015772433.1\|2346871_2347399_+	hypothetical protein	NA	NA	NA	NA
WP_015772434.1\|2347401_2348364_+\|capsid	phage major capsid protein	S5Y5B1	Mycobacterium_phage	2.9e-124	69.2

DBSCAN-SWA_2

2461884 : 2483080

Gordonia_phage(22.22%)

capsid,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015772538.1\|2461884_2462655_+	phage regulatory protein/antirepressor Ant	A0A0K0N5U2	Gordonia_phage	4.6e-27	33.5
WP_015772539.1\|2462651_2462855_+	hypothetical protein	NA	NA	NA	NA
WP_015772541.1\|2462956_2463976_+	hypothetical protein	NA	NA	NA	NA
WP_015772543.1\|2464201_2464483_+	hypothetical protein	NA	NA	NA	NA
WP_015772544.1\|2464475_2465324_+	PD-(D/E)XK nuclease-like domain-containing protein	G8CLD3	Synechococcus_phage	6.1e-25	34.4
WP_015772545.1\|2465316_2465958_+	hypothetical protein	G9FH58	Rhodococcus_phage	2.4e-37	50.9
WP_015772410.1\|2466272_2466524_+	glutaredoxin family protein	NA	NA	NA	NA
WP_015772411.1\|2466525_2466939_+	single-stranded DNA-binding protein	V5RAD6	Arthrobacter_phage	7.9e-18	47.7
WP_015772412.1\|2467056_2467410_+	hypothetical protein	NA	NA	NA	NA
WP_041288482.1\|2467610_2467871_+	hypothetical protein	A0A159B6S1	Tsukamurella_phage	7.4e-22	63.3
WP_015772414.1\|2467860_2468256_+	hypothetical protein	A0A1S5S8Q1	Streptococcus_phage	8.1e-12	35.1
WP_015772415.1\|2468374_2468560_+	hypothetical protein	NA	NA	NA	NA
WP_015772416.1\|2468556_2468922_+	WhiB family transcriptional regulator	A0A2P1N2X5	Mycobacterium_phage	1.6e-06	38.2
WP_015772417.1\|2468918_2469170_+	DUF2188 domain-containing protein	NA	NA	NA	NA
WP_015772418.1\|2469159_2470116_+	hypothetical protein	A0A2K9VH47	Gordonia_phage	1.6e-34	34.9
WP_015772419.1\|2470112_2470472_+	hypothetical protein	NA	NA	NA	NA
WP_015772420.1\|2470468_2471752_+	AAA family ATPase	C7BGG1	Burkholderia_phage	5.8e-43	30.8
WP_015772421.1\|2471748_2471952_+	hypothetical protein	NA	NA	NA	NA
WP_015772423.1\|2472366_2472648_+	hypothetical protein	NA	NA	NA	NA
WP_015772424.1\|2472644_2473025_+	DUF4326 domain-containing protein	A0A142K9N0	Gordonia_phage	3.4e-23	40.8
WP_015772547.1\|2473021_2473186_+	hypothetical protein	NA	NA	NA	NA
WP_015772548.1\|2473182_2473386_+	hypothetical protein	NA	NA	NA	NA
WP_015772549.1\|2473437_2473965_+	hypothetical protein	NA	NA	NA	NA
WP_015772550.1\|2473961_2474144_+	hypothetical protein	NA	NA	NA	NA
WP_015772551.1\|2474429_2474747_+	HNH endonuclease	A0A1D8ETP1	Propionibacterium_phage	4.8e-15	47.6
WP_015772552.1\|2474904_2475123_+	hypothetical protein	NA	NA	NA	NA
WP_143713298.1\|2475073_2476549_+	hypothetical protein	A0A0H4IRX9	Propionibacterium_phage	8.8e-112	48.4
WP_015772554.1\|2476545_2477967_+\|portal	phage portal protein	A0A068F3B8	Mycobacterium_phage	5.2e-77	38.3
WP_015772555.1\|2477950_2478700_+	hypothetical protein	A0A1D8ETP7	Propionibacterium_phage	1.5e-38	43.3
WP_015772556.1\|2478795_2479230_+	hypothetical protein	A0A0E3DMH3	Propionibacterium_phage	6.6e-07	39.1
WP_015772557.1\|2479241_2480141_+\|capsid	phage major capsid protein	A0A2H4IYA3	uncultured_Caudovirales_phage	1.3e-126	75.9
WP_015772558.1\|2480140_2480320_+	hypothetical protein	NA	NA	NA	NA
WP_015772559.1\|2480333_2480741_+	hypothetical protein	NA	NA	NA	NA
WP_015772560.1\|2480742_2481078_+	hypothetical protein	NA	NA	NA	NA
WP_143713299.1\|2481094_2481346_+	hypothetical protein	NA	NA	NA	NA
WP_015772563.1\|2481747_2482305_+	hypothetical protein	A0A0B5A550	Streptococcus_phage	6.0e-37	49.4
WP_015772564.1\|2482409_2482691_+	hypothetical protein	NA	NA	NA	NA
WP_015772565.1\|2482795_2483080_+	hypothetical protein	A0A2K9VEP4	Gordonia_phage	3.5e-09	47.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_013174

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection