CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_013222	Robiginitalea biformata HTCC2501, complete sequence	4 crisprs	csa3,WYL,DEDDh,PrimPol	0	1	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_013222_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013222_1

307767-307882

Orphan

Consensus_repeat	Method
ATTGCTTGCCTGGCGGCAAGCTTCCCTACTCGCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013222_1

>merge|NC_013222|1|307767-307882|CRISPRCasFinder
ATTGCTTGCCTGGCGGCAAGCTTCCCTACTCGCTCCATCAACACATTCTCAATAAGGAACAAGTCAAAACTTCGCGGTGGGATTGCTTGCCTGACGGCAAGCTTCCCTACTCGCTC

>NC_013222|1|1|307767-307882|CRISPRCasFinder
ATTGCTTGCCTGGCGGCAAGCTTCCCTACTCGCTC	CATCAACACATTCTCAATAAGGAACAAGTCAAAACTTCGCGGTGGG
ATTGCTTGCCTGACGGCAAGCTTCCCTACTCGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013222.1\|WP_012813845.1\|302036_305207_+\|cytochrome-c-biogenesis-protein-CcsA	unknown	unknown	gnl\|CDD\|274447
NC_013222.1\|WP_012813841.1\|298743_299268_+\|DUF4142-domain-containing-protein	unknown	unknown	gnl\|CDD\|379301
NC_013222.1\|WP_041326884.1\|305250_305967_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|99793
NC_013222.1\|WP_148214265.1\|312078_312567_-\|DUF305-domain-containing-protein	unknown	unknown	gnl\|CDD\|367619
NC_013222.1\|WP_041327382.1\|306391_307324_+\|DUF4382-domain-containing-protein	unknown	unknown	gnl\|CDD\|379555
NC_013222.1\|WP_015752921.1\|315729_316200_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379639
NC_013222.1\|WP_015752918.1\|313300_313708_-\|DUF2911-domain-containing-protein	unknown	unknown	gnl\|CDD\|378565
NC_013222.1\|WP_015752919.1\|313734_314487_-\|cation-transporter	unknown	unknown	gnl\|CDD\|238219
NC_013222.1\|WP_015752917.1\|312591_313299_-\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|225723
NC_013222.1\|WP_015752923.1\|316758_318264_-\|FMN-binding-glutamate-synthase-family-protein	unknown	unknown	gnl\|CDD\|239202
NC_013222.1\|WP_012813842.1\|299267_299609_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|259988
NC_013222.1\|WP_012813848.1\|307519_307705_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|182452
NC_013222.1\|WP_041327379.1\|297339_298005_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|99793
NC_013222.1\|WP_083760664.1\|298006_298693_+\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472
NC_013222.1\|WP_012813843.1\|299682_301035_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|163503
NC_013222.1\|WP_148214264.1\|308061_309198_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271185
NC_013222.1\|WP_015752922.1\|316204_316762_-\|two-pore-domain-potassium-channel-family-protein	unknown	unknown	gnl\|CDD\|369572
NC_013222.1\|WP_012813851.1\|310238_312050_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|379862
NC_013222.1\|WP_041326885.1\|314489_315716_-\|permease	unknown	unknown	gnl\|CDD\|281730
NC_013222.1\|WP_012813844.1\|301242_302040_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806

Protein	Function_ID	Function_description	E-value
NC_013222.1\|WP_012813845.1\|302036_305207_+\|cytochrome-c-biogenesis-protein-CcsA	gnl\|CDD\|274447	TIGR03144, cytochrome_c_biogenesis_protein_chloroplast, cytochrome c-type biogenesis protein CcsB. Members of this protein family represent one of two essential proteins of system II for c-type cytochrome biogenesis. Additional proteins tend to be part of the system but can be replaced by chemical reductants such as dithiothreitol. This protein is designated CcsB in Bordetella pertussis and some other bacteria, resC in Bacillus (where there is additional N-terminal sequence), and CcsA in chloroplast. We use the CcsB designation here. Member sequences show regions of strong sequence conservation and variable-length, poorly conserved regions in between; sparsely filled columns were removed from the seed alignment prior to model construction. [Energy metabolism, Electron transport, Protein fate, Protein modification and repair].	5.70234e-61
NC_013222.1\|WP_012813841.1\|298743_299268_+\|DUF4142-domain-containing-protein	gnl\|CDD\|379301	pfam13628, DUF4142, Domain of unknown function (DUF4142). This is a bacterial family of unknown function.	4.44813e-34
NC_013222.1\|WP_041326884.1\|305250_305967_-\|hypothetical-protein	gnl\|CDD\|99793	cd06196, FNR_like_1, Ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which varies in orientation with respect to the NAD(P) binding domain. The N-terminal region may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Ferredoxin is reduced in the final stage of photosystem I. The flavoprotein Ferredoxin-NADP+ reductase transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) which then transfers a hydride ion to convert NADP+ to NADPH.	8.73848e-112
NC_013222.1\|WP_148214265.1\|312078_312567_-\|DUF305-domain-containing-protein	gnl\|CDD\|367619	pfam03713, DUF305, Domain of unknown function (DUF305). Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	1.22563e-10
NC_013222.1\|WP_041327382.1\|306391_307324_+\|DUF4382-domain-containing-protein	gnl\|CDD\|379555	pfam14321, DUF4382, Domain of unknown function (DUF4382). This family is found in bacteria and archaea, and is typically between 142 and 161 amino acids in length.	1.26992e-14
NC_013222.1\|WP_015752921.1\|315729_316200_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379639	pfam14534, DUF4440, Domain of unknown function (DUF4440).	8.27157e-07
NC_013222.1\|WP_015752918.1\|313300_313708_-\|DUF2911-domain-containing-protein	gnl\|CDD\|378565	pfam11138, DUF2911, Protein of unknown function (DUF2911). This bacterial family of proteins has no known function.	1.16128e-07
NC_013222.1\|WP_015752919.1\|313734_314487_-\|cation-transporter	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	5.35263e-12
NC_013222.1\|WP_015752917.1\|312591_313299_-\|PepSY-domain-containing-protein	gnl\|CDD\|225723	COG3182, PiuB, Uncharacterized iron-regulated membrane protein [Function unknown].	0.00315469
NC_013222.1\|WP_015752923.1\|316758_318264_-\|FMN-binding-glutamate-synthase-family-protein	gnl\|CDD\|239202	cd02808, GltS_FMN, Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.	5.93271e-158
NC_013222.1\|WP_012813842.1\|299267_299609_+\|hypothetical-protein	gnl\|CDD\|259988	cd13921, Amicyanin, Amicyanin is a type I blue copper protein that plays an essential role in electron transfer. In Paracoccus denitrificans bacteria, amicyanin acts as an intermediary of a three-member redox complex along with methylamine dehydrogenase (MADH) and cytochrome c-551i. The electron is transferred from the active site of MADH via the amicyanin copper ion to the cytochrome heme iron. The electron transfer from MADH to cytochrome c-551i does not involve a ternary complex but occurs via a ping-pong mechanism in which amicyanin uses the same interface for the reactions with MADH and cytochrome c-551i.	1.20062e-24
NC_013222.1\|WP_012813848.1\|307519_307705_+\|CsbD-family-protein	gnl\|CDD\|182452	PRK10428, PRK10428, hypothetical protein; Provisional.	3.83152e-12
NC_013222.1\|WP_041327379.1\|297339_298005_+\|hypothetical-protein	gnl\|CDD\|99793	cd06196, FNR_like_1, Ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which varies in orientation with respect to the NAD(P) binding domain. The N-terminal region may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Ferredoxin is reduced in the final stage of photosystem I. The flavoprotein Ferredoxin-NADP+ reductase transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) which then transfers a hydride ion to convert NADP+ to NADPH.	3.82459e-121
NC_013222.1\|WP_083760664.1\|298006_298693_+\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	4.24159e-81
NC_013222.1\|WP_012813843.1\|299682_301035_+\|hypothetical-protein	gnl\|CDD\|163503	TIGR03791, TTQ_mauG, tryptophan tryptophylquinone biosynthesis enzyme MauG. Members of this protein family are the tryptophan tryptophylquinone biosynthesis (TTQ) enzyme MauG, as found in Methylobacterium extorquens and related species. This protein is required to complete the maturation of the TTQ cofactor in the methylamine dehydrogenase light (beta) chain.	3.59542e-09
NC_013222.1\|WP_148214264.1\|308061_309198_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271185	cd01185, INTN1_C_like, Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain. IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.26994e-32
NC_013222.1\|WP_015752922.1\|316204_316762_-\|two-pore-domain-potassium-channel-family-protein	gnl\|CDD\|369572	pfam07885, Ion_trans_2, Ion channel. This family includes the two membrane helix type ion channels found in bacteria.	0.000643254
NC_013222.1\|WP_012813851.1\|310238_312050_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|379862	pfam16576, HlyD_D23, Barrel-sandwich domain of CusB or HlyD membrane-fusion. HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.	8.59073e-91
NC_013222.1\|WP_041326885.1\|314489_315716_-\|permease	gnl\|CDD\|281730	pfam03773, ArsP_1, Predicted permease. This family of integral membrane proteins are predicted to be permeases of unknown specificity.	1.3644e-42
NC_013222.1\|WP_012813844.1\|301242_302040_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	9.33411e-11

>NC_013222.1|WP_012813848.1|307519_307705_+|CsbD-family-protein
MTNEELKGKWNQVKGKFKQRYGNLTDDDVTFSEGKFDEMLGRIQEKTGKRKEEIRKEIESW
>NC_013222.1|WP_041327382.1|306391_307324_+|DUF4382-domain-containing-protein
MKRTIQSVILATAVTAFTACSSDDRGESMPEETSQTTFKITDAPIDDAQVEGVFVTLADVRVDGQSLEGFSKTTIELSALVEGQTLTLGELDLAADSYSSLELVLDTQTDAAGNTPANYIALANGTKEELEASAETIRVTDGFEVIAGAANEIVIDFDLRKTITKSQGALEADYAFASTSQLEAGIRVVNEQATGEIEGTVTDSQDYAETIIVYAYPEGTFNAEAETQGEVQFANAVTSSKVSGLDNSYSLNFLEEGTYELVFASYEETEGSVNFATLLEVESTTGLNLGALTLSAALQLSANVTVTGTL
>NC_013222.1|WP_041326884.1|305250_305967_-|hypothetical-protein
MRGFIFPYQVSLLGIERVNQDIFRLQLEKPDGYTFRPGQAIDVSIAEPGHELDVAPFTLFNRPADPYLELIVKIRPNPGSLTGSLSRLWPGATLQITAPWEVYRYIGPGVFLAAGTGITAFLPLLRELAAQGKQLYPDHHLVYAISEPSDMLYEEELASLLSHGFTCVVSRSPVPTGKGWYTGHISENLLRQVVHKDASNYYVCGPRSFEKSIHGLLLGMGVDAAHVQTGYPIYKEAL
>NC_013222.1|WP_012813845.1|302036_305207_+|cytochrome-c-biogenesis-protein-CcsA
MNRVRPTHFTSRILAYLGSTRLMALLFLALGVAMGWATFIENDLGTPAAQALVYRAWWFEGLMLLFVVNFLLNIRKYGLEKRRKWPVLLVHASLVIIILGAFVTRYFGYTGLMTIREGEVSNTVYSDEAYLRVAMEEPRGSTPTRRIIERPVLLSGATPWHNRFELHTEFNGSPIQVSYRDFIPDARYRFREQTGGALYLRIVETHRDERHEHYLREGVKTNFHGHLFTLNAPQPGAFNFTYISDTLYLSPFRAGSHTDMVSRESTPLPRRVNERARRGLYRFGDLQFALSAPPRAGILLLEPARAEQRGESPDALLLQIRAGDSVRDTVVLGQARAAGEPVHLNIDGKDFELSYGSKLHSLPFALELLDFDAQKYPGTQTGYSGFKSRVLVRDPDRTFEADIFMNHVLDHGGFRFYQASFHADEKGTILSVNHDAAGTLITYTGYFLLYLGLLGVLFSRHTRFARVVRQLNAHAASRAGVLGLTLTLSGALGAQQSPDPTHPEIQARLDSIVDYYAPPPDHTSRFAGLVVQDPDGRMKPMDSYASEILRKLSKREVYRNLTADQVVHSMLQLPEIWFNVPLIYLGKDSRPLRNLLGISVPLDRVPLVAFFRGDGGYKIEAEVKTAHRARIPSQFQKDLIAVDGRVHLLHAILSGRAMRLFPLPGHDMNLWISTAELGEKAQTLTAPDSTFIAQALPIYFDACSTAARTGDYTEATTILRHLERFQRHHGAEVIPNPLKIRTEMLYNRLNLFKNLVQAYLFGGLLLLALAIRGIFRASRPLRLGIRLLMAVLWLCYAIHTAGLGLRWYIAGHAPWSDAYETMIYIAWATMLFGIYLGRKSALAMASTAFVVSVILMVAHWNWLDPAVANLQPVLNSYWLMIHVAIIVASYGPFTVAMILCLLVLAGMVFLNRRNRTSLSAPLRQLLLLAELAMTMGLVMLTIGNFLGGQWANESWGRYWAWDPKETWALVSILVYALIIHMRLVPGLRGRWVFAMMGVVGYSAILMTYFGVNFYLSGLHAYASGEQLVTPSVVFYAIGVVGILGVVSYVKAHRHHV
>NC_013222.1|WP_012813844.1|301242_302040_+|CPBP-family-intramembrane-metalloprotease
MKNSKIIFTTLFAFGVYFGLDDLYFGTVRNGIDQVVNQRGTSHNLAYLLSGIPLYLGLLIMHRPQDFFKVLGLSGPLGRAVRFAFLCTLPMVLGYAILFSPSREVTLNGLLISGLAAAFFEEVFYRGFLFGQLYRYTRLGFIPAVALGALLFAAIHLYQSQDLWISLGVFATTFLGAVVFAWTYAEWDHNIWVPVMLHLFMNLAWMLFAVSDNALGGVYANVFRIVTIGAIIGLTLFYKRRRNIPLEVTRHTLWLKPGQPVGYTP
>NC_013222.1|WP_012813843.1|299682_301035_+|hypothetical-protein
MKKKYIAAAGSLLLAAGLLTRCTKTETITETITETVTDTIIQTEIDTLFLDPSLVAEGKEIFRHDTFGDEAFWSGVLHLDKAILGEANGGYGDGVSPATALVVGLKVDAEALPSEVVSAIQAGQVDLEDPATTVELLRLNSVVGVKGNFDDNGDLSSIGITCALCHSTVDDSFADGIGKRLDGYPNRDLNVGVIVSLTDNAQFLADLLHVDEATVRTVLTGWGPGKFNAGLMADGIATKPDGSIAANLLPAAYGLQGVHLATYTGWGDVTYWNAFVANLEMHGQGNFTDARLNDPIQFPIAAENNFGNVTNSPDLITGKLPALQAYQLSLKAPIPPVGSFDAAAAERGKVVFEGVAQCATCHIAPIFTDAGQNLHTAEEIGIDDFEAKRSPTGKYRTTPLRGLWARTQGGFYHDGRFATLAEVIDHYDSHFQLNLSTADKNDLSEYLMSL
>NC_013222.1|WP_012813842.1|299267_299609_+|hypothetical-protein
MKIVYGLLFPLGFWATLITGSDREAIPDARLPKRHTVEIFRMKFNPAELHVNPGDTVVWVNKDFVPHDVTEEKTRAWTSHPFGQNESWSRVITEDVDYFCNLHKVMKGTIVVE
>NC_013222.1|WP_012813841.1|298743_299268_+|DUF4142-domain-containing-protein
MKKLVIICCLGLFASATLLGQDKTNLSDAEIASVAVVANQIDIEFAEMAIKKSRNAEILDFAKRMVQDHQAVIGQASALVSKLGVQPQDNPISQSMLADARLTQKELRKAPRKAFDARYIANEVAYHKAVIEAIRDVLVPNTENGELKELLQTVLPALEAHLGHAEMVQKKLGK
>NC_013222.1|WP_083760664.1|298006_298693_+|GTP-cyclohydrolase-I-FolE
MKQDAQPGARTQESQRNGEADPVSPGAVGAPGIPDRSRGEKIDTIAHHFGKIMQALGMDLSDTSLADTPMRVARMYVNETFRGLSAKNFPRISFFEKAPGTPEMIVVNDITLYSYCEHHFVPFFGKVHVAYIPGDRLLGLSKVNRVVDYLSRKPHLQERLTREIADTLSELLQTRHVAVFVEAQHLCVASRGVRDAKSITRTGCYLGQFQNTHTRAEFMASLKMQGSL
>NC_013222.1|WP_041327379.1|297339_298005_+|hypothetical-protein
MNYHVQIKSISRLTHDTLCLRLSKPHGYRYGIGQAIEVAIDNPGYEQQFRPFTLTSLPFDPYLELIVKVYPDHGGFTQALSRLGENGPLIITAAWDSYDYRGEGVFIAAGSGITPFIPMIRQLSLSGRIPGHTLLYANKTEADIIHKQALNKALGSRFINILSREYHSKLDYGRLDQAYLKDKVSDFSEHFYICGPEAFSGAIKGYLINQGAAEAQIQIGY
>NC_013222.1|WP_148214264.1|308061_309198_+|tyrosine-type-recombinase/integrase
MLKFSADFLLFPIFSPKPSLFRHLKMAVHLRSRKLKSGDRSLYLDIHHHGDRWREFLKIRISPKDSDRTEKKRIAERIRANRELELLSQSTGHIPSHLTNLNFFDFAENYLSNYPFKDVRIVHNAVQKFKVALGNTRLTFAQITPKVMEAFKDYLIHESGLTGETAHNYFTRFKKILKAAKIKGYLREMPTADIRFANPNKDDTIRKQVLDTKELQILATTHCGNSEVKRAFLFACYTSLGLAEIKLLKWSNINKGRLITYRNKTGEIINNRLNPTALIILGEPKGRNEFVFQLQKLSNNGVNKAIEYWVKRAGIQKHITFYCARHTFACQLLIHGANLKTVADAMGHSSTQSTLKYLNYVQKLQDEAIDKLPVLQID
>NC_013222.1|WP_012813851.1|310238_312050_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MNKNIIYIGTALIVGLLAGYFIFSISAEDEIAVKDLSDMSDTHDHSGETAEQMWTCSMHPQIMQPEPGDCPICGMDLIPADTGTEGLSANEIRMTENAMALANIRTTVVGVGGMDGNSLKLSGKIRENEEANAVQATYFGGRIERLYVNYAGERVAKGRLLATIYSPELVSAQQELLTATSLKESQPALYKAVRNKLKLWKLSDKQINGIEESGQVQENFPVYATVSGTVTEKLVEEGDYVKQGQPLYKIANLNSVWAVFDAYENQIASLKTGQIIKLTTNAYPNKEFTAKVSFVDPLLNSTTRTVMVRAVLNNSEGLLKPGMFVEGRIDMPNDESGKVISVPSTAVMWTGERSVVYVKTNPDEPIFEMREVSLGNTNGESFTILSGLEGGDEIVTNGTFTVDAAAQLQGKKSMMNAKGGKTMTGHEGHLGMQPESSETSEPTVDHAKMDKRLKVSNNFQEQLKVVFEGYTLLKDALVADNAGKAQSSAKEIGKSLDGVDMKLLENDKAHNHWMTLQKEIRASANAIAIATEIAEQRSHFKHLSAHMISTIQLFGINQTVFSNYCPMADSNNGAYWVSLEKEIRNPYYGEEMLTCGEITATLR
>NC_013222.1|WP_148214265.1|312078_312567_-|DUF305-domain-containing-protein
MNSIENTTSGKSKNQYTRFVAMLSCSFLAMYITMYLNTYEWDHVWFSLTRFYMVCLGIAAMAIIMFVAMRGMYQNKTKNVAIVLGSIILFTGALILVREQRSTVGDILWMKAMIPHHSIAILTSERADLKDPEVKKLAEEIIRAQEREISEMKAMINRLQEE
>NC_013222.1|WP_015752917.1|312591_313299_-|PepSY-domain-containing-protein
MVSRKTAKWIRKTHRYLGLFLGIQFLIWTISGMYFSWTDIDEIHGDHYKKASPVQTSFNDLLGTSQLATKEPVQSLELLEIANEPYYWINEAQLYNARTGRKKNGISKEEAQQVASRYMLADLKIAEIQRIDTVDKHHEYRGRPLPAYEISYETPQNLKAYVAIENGAFQTVRHRDWRWFDFLWMTHTMDYQGRDDFNTVLLRAFSLLGLITVLSGFVLWYISSLSIRKLKKKFK
>NC_013222.1|WP_015752918.1|313300_313708_-|DUF2911-domain-containing-protein
MKNMIVVFGIFLIASCKQECKGPKENVTKEVETVSQAAESDKKKPFSPHTETMTMVGDAQIPIDYSSPGVRNRKIFDGLLPFNASDVGLRLKVTPKTTEEIKEHLEYRIVKATETSGTISMSWKKVSIEFPFKIE
>NC_013222.1|WP_015752919.1|313734_314487_-|cation-transporter
MKHTYHIQGMTCNGCRTSVEDKLSKVSGVTNASVNLEKEEAVIQMDSYIDTATFQKVLSEKYTISEKRAEKNALVSTDNDANNFFAKGETEKSKLQQLKPLLIILGYIAIATILLNYQRENWNSAMLDFMGLFFIVFSFFKILDLKGFPDSFRMYDPLAKVVPAYAWVYPFIESALGLMFLIRFEIPIALIATLVILGITTVGVTKILLDKKSIQCACLGTALKLPMTEATFIENAIMIAMAVVMLTRIL
>NC_013222.1|WP_041326885.1|314489_315716_-|permease
MSEFLQQWGEAAYTTTGFFWMALWAFILGYIISSMIQIFVTEKRMQRTMGKDESKSVLLGTFFGFISSSCSFAALASAKSLFKKGASFVSSVAFLLASTNLVIELGIIISIFLGWQFVVGEYMGGLLLILISWILIRTVNPIKLIEEARKNLEGQEDDEMSDNQDWKKQIQQENSWARVAKKYKMEWQMVWKDVTVGFTIAGIVAAFVPDSFFQTLFINSGQGNTDFTFLEILEHVIVGPVAAFLTFIGSMGNIPLAALLFGKGVSFAGVMAFIFSDLVVFPVLRINAKYYGWKMSIFILFLLFTALIVASLVLHYSFDLMSILPDPSQVKFQDKDHFKIDYTFYLNISFLAISAFLIYLGFFKRKDVEHSMSEMAPKSPFLESVLKYAAYICYVWLVGGLIVKFFIK
>NC_013222.1|WP_015752921.1|315729_316200_-|nuclear-transport-factor-2-family-protein
MRKLTTILTLFAITTSQVYCQNAKKEKEAVLKVMKSYKEALQNLTTEGTYELFASDSEVFESGGVEGSYAHYIEHHLGPELEHFKKFDFSDYQIDVEVDLPYAFTTETYIYTIVLNPNDKGEGRTIKKKGVATSILKRVDGKWQIIKTHSSSRNAK
>NC_013222.1|WP_015752922.1|316204_316762_-|two-pore-domain-potassium-channel-family-protein
MSEEKDIETTAAFYWQLFNSSKYVLLIVLLATAIGLYVLPNIDASYVVIILLALTLSKIGFIIALSFNQLMKIIGQSHLLSHVLVLFGYLIILIVFSFAIDYTALHLIDSAHFKINNSSGSNGLLAFFNMSYFSLITFSSVGYGDIVPITVTAKTLVVLEVALRFFVLVFGIANVNRIRVNNLKT
>NC_013222.1|WP_015752923.1|316758_318264_-|FMN-binding-glutamate-synthase-family-protein
MRRGFIIMSVLLVLVLAAMLILYPLWWGVALIIIPLLILGLIDYCQKSNNIRRTYPLFGRITNLLEKQRHVFQEIVLLNRAEGKPFNWIQKEIIYKRAADANKSQPFGTQIPYDKVGREWFTHSTYPVKEVNDDFRVTVGSSLCTQPYSSSILNLSGMSYGSISKNATLALNGGAKIAGFAQNTGEGGFTPYHQEYGADIIFQIGTGYFGCRTKEGNFDTEKFRDIALHEVVKMIEIKISQGAKPGFGAILPAKKNTEEIAKFRVVEKGKQILSPPHHSAFGSDEEMIFFIDKLRKLSNGKPIGIKLCIGQKDEFDSMAQSLAKNQNYPDFIAIDGAEGGTGAAHMESLHWAGLPIVEAIHFAHSTLVKHKIRDEIKLMAAGKIISAFDIYRMLALGADACYSARGMMFALGCVQSLKCNLDKCPTGITTMEPSRVKSLVVEDKKAKVANYHKNTMEAFKELLGSMGLENRKGIQKKYIVRRINETETKTYDEIFVNPSKE

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Crispr_ID: NC_013222_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013222_2

440758-440871

Orphan

Consensus_repeat	Method
TGTATTTTCAGAATGGAGCCGCCAGGAACTGCGGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013222_2

>merge|NC_013222|2|440758-440871|CRISPRCasFinder
TGTATTTTCAGAATGGAGCCGCCAGGAACTGCGGAGCTGTAACGAACTTTAGTGAGTGGAGGCGAAGCGATTCCTGGTGTATTTTCAGAATGGAGCCGCCAGGAACTGCGGAGC

>NC_013222|2|2|440758-440871|CRISPRCasFinder
TGTATTTTCAGAATGGAGCCGCCAGGAACTGCGGAGC	TGTAACGAACTTTAGTGAGTGGAGGCGAAGCGATTCCTGG
TGTATTTTCAGAATGGAGCCGCCAGGAACTGCGGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013222.1\|WP_015753036.1\|434711_435686_-\|deoxyhypusine-synthase-family-protein	unknown	unknown	gnl\|CDD\|376661
NC_013222.1\|WP_015753048.1\|445062_445383_+\|YegP-family-protein	unknown	unknown	gnl\|CDD\|377831
NC_013222.1\|WP_015753033.1\|432008_432959_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187580
NC_013222.1\|WP_015753053.1\|450956_451580_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100006
NC_013222.1\|WP_041326903.1\|449826_450930_+\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|235167
NC_013222.1\|WP_015753042.1\|442098_442764_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NC_013222.1\|WP_015753038.1\|436668_438132_-\|arginine-decarboxylase	unknown	unknown	gnl\|CDD\|143503
NC_013222.1\|WP_148214270.1\|444539_445070_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376158
NC_013222.1\|WP_015753037.1\|435742_436615_-\|agmatinase	unknown	unknown	gnl\|CDD\|212539
NC_013222.1\|WP_015753041.1\|439836_440304_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|238385
NC_013222.1\|WP_083760671.1\|443743_444292_+\|DUF4352-domain-containing-protein	unknown	unknown	gnl\|CDD\|378684
NC_013222.1\|WP_015753040.1\|439382_439817_-\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|235138
NC_013222.1\|WP_187289181.1\|445945_446920_+\|beta-lactamase-family-protein	unknown	unknown	gnl\|CDD\|365903
NC_013222.1\|WP_041326902.1\|446955_449055_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|227903
NC_013222.1\|WP_015753032.1\|431451_431946_-\|hypothetical-protein	unknown	unknown	unknown
NC_013222.1\|WP_015753044.1\|443303_443747_+\|hypothetical-protein	unknown	unknown	unknown
NC_013222.1\|WP_015753035.1\|434400_434709_-\|hypothetical-protein	unknown	unknown	unknown
NC_013222.1\|WP_015753051.1\|449236_449806_+\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|293786
NC_013222.1\|WP_015753034.1\|432946_434320_-\|30S-ribosomal-protein-S6--L-glutamate-ligase	unknown	unknown	gnl\|CDD\|182468
NC_013222.1\|WP_083760670.1\|438568_439276_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013222.1\|WP_015753036.1\|434711_435686_-\|deoxyhypusine-synthase-family-protein	gnl\|CDD\|376661	pfam01916, DS, Deoxyhypusine synthase. Eukaryotic initiation factor 5A (eIF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalyzed by the enzyme deoxyhypusine synthase (DS) EC:1.1.1.249. The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation.	4.37488e-39
NC_013222.1\|WP_015753033.1\|432008_432959_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187580	cd05272, TDH_SDR_e, L-threonine dehydrogenase, extended (e) SDRs. This subgroup contains members identified as L-threonine dehydrogenase (TDH). TDH catalyzes the zinc-dependent formation of 2-amino-3-ketobutyrate from L-threonine via NAD(H)-dependent oxidation. This group is distinct from TDHs that are members of the medium chain dehydrogenase/reductase family. This group has the NAD-binding motif and active site tetrad of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	6.32413e-175
NC_013222.1\|WP_015753053.1\|450956_451580_-\|RidA-family-protein	gnl\|CDD\|100006	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	9.78666e-78
NC_013222.1\|WP_041326903.1\|449826_450930_+\|acyltransferase-family-protein	gnl\|CDD\|235167	PRK03854, opgC, glucans biosynthesis protein MdoC.	1.69456e-14
NC_013222.1\|WP_015753042.1\|442098_442764_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.40073e-33
NC_013222.1\|WP_015753038.1\|436668_438132_-\|arginine-decarboxylase	gnl\|CDD\|143503	cd06830, PLPDE_III_ADC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase. This subfamily includes plants and biosynthetic prokaryotic arginine decarboxylases (ADC, EC 4.1.1.19). ADC is involved in the biosynthesis of putrescine, which is the precursor of aliphatic polyamines in many organisms. It catalyzes the decarboxylation of L-arginine to agmatine, which is then hydrolyzed to putrescine by agmatinase. ADC is homologous to eukaryotic ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC), which are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. Homodimer formation and the presence of both PLP and Mg2+ cofactors may be required for catalytic activity. Prokaryotic ADCs (biodegradative), which are fold type I PLP-dependent enzymes, are not included in this family.	2.00128e-145
NC_013222.1\|WP_148214270.1\|444539_445070_+\|hypothetical-protein	gnl\|CDD\|376158	pfam18735, HEPN_RiboL-PSP, RiboL-PSP-HEPN. RiboL-PSP-HEPN. Fused to endoRNase L-PSP ; in operon with ParB.	0.000138888
NC_013222.1\|WP_015753037.1\|435742_436615_-\|agmatinase	gnl\|CDD\|212539	cd11593, Agmatinase-like_2, Agmatinase and related proteins. This family includes known and predicted bacterial and archaeal agmatinase (agmatine ureohydrolase; AUH; SpeB; EC=3.5.3.11), a binuclear manganese metalloenzyme that belongs to the ureohydrolase superfamily. It is a key enzyme in the synthesis of polyamine putrescine; it catalyzes hydrolysis of agmatine to yield urea and putrescine, the precursor for biosynthesis of higher polyamines, spermidine, and spermine. As compared to E. coli where two paths to putrescine exist, via decarboxylation of an amino acid, ornithine or arginine, a single path is found in Bacillus subtilis, where polyamine synthesis starts with agmatine; the speE and speB encode spermidine synthase and agmatinase, respectively. The level of agmatinase synthesis is very low, allowing strict control on the synthesis of putrescine and therefore, of all polyamines, consistent with polyamine levels in the cell. This subfamily belongs to the ureohydrolase superfamily, which includes arginase, agmatinase, proclavaminate amidinohydrolase, and formiminoglutamase.	3.23227e-107
NC_013222.1\|WP_015753041.1\|439836_440304_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|238385	cd00756, MoaE, MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.	5.5654e-42
NC_013222.1\|WP_083760671.1\|443743_444292_+\|DUF4352-domain-containing-protein	gnl\|CDD\|378684	pfam11611, DUF4352, Domain of unknown function (DUF4352). Members of these family are putative lipoproteins that fall into the Antigen MPT63/MPB63 (immunoprotective extracellular protein) superfamily.	2.86787e-08
NC_013222.1\|WP_015753034.1\|432946_434320_-\|30S-ribosomal-protein-S6--L-glutamate-ligase	gnl\|CDD\|182468	PRK10446, PRK10446, 30S ribosomal protein S6--L-glutamate ligase.	2.09355e-124
NC_013222.1\|WP_187289181.1\|445945_446920_+\|beta-lactamase-family-protein	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	4.8887e-36
NC_013222.1\|WP_041326902.1\|446955_449055_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|227903	COG5616, COG5616, Predicted integral membrane protein [Function unknown].	2.84687e-34
NC_013222.1\|WP_015753040.1\|439382_439817_-\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|235138	PRK03604, moaC, bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional.	2.0152e-66
NC_013222.1\|WP_015753051.1\|449236_449806_+\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	1.99862e-25
NC_013222.1\|WP_015753048.1\|445062_445383_+\|YegP-family-protein	gnl\|CDD\|377831	pfam07411, DUF1508, Domain of unknown function (DUF1508). This family represents a series of bacterial domains of unknown function of around 50 residues in length. Members of this family are often found as tandem repeats and in some cases represent the whole protein. All member proteins are described as being hypothetical.	8.01961e-18

>NC_013222.1|WP_015753041.1|439836_440304_-|molybdenum-cofactor-biosynthesis-protein-MoaE
METKKETEKGIAKKKALFIEGPIAPDFIAQSIAKHQSKTGIGAHDIFLGQVRADEIDGKTVTGIAYTAYEEMAHEKMHEIREDLFGKYDLSCMHIYHSLGEVAVGEICLFVFVSSPHRKAVFEALHELVERIKKELPVFGKELFGDDSYAWKVNK
>NC_013222.1|WP_015753040.1|439382_439817_-|cyclic-pyranopterin-monophosphate-synthase-MoaC
MVDITHKEVTLRSATAEAIVRTGREETIRAIREGRVPKGDVLEMSKAAGLLGVKQTPYLLPDCHPLPIEEARVAYEMDGMEIRILMTVRTHYKTGVEVEAMHGASVVALTIYDMLKPIDKEVEIRTIRLLEKTGGKSDIRRSAD
>NC_013222.1|WP_083760670.1|438568_439276_+|hypothetical-protein
MKRLIFCAIASVLSAWGVGAQISPGAYKAVEMHGDTTRNHLLLVSDNYIIHTTYDSQPAHFISTMGGFYEIGEDSLRVDLEFNTDYEKTGEKVHRVSYGYADGNLIFNENHARPYRREPDLDQPLDGAWLFATRGPDTGQERRGDNSARKTLKFLNNGYFQWVAYNSETMDFMGSGGGRYAADQGIYTEQIQFFSRDDSRVGAELEFSFERKGDDWHHTGKNSRGEPMYEIWSIR
>NC_013222.1|WP_015753038.1|436668_438132_-|arginine-decarboxylase
MNITYRDLIDQTYYFPTEEFDLEGDRLRFHGVSLTDLIERYGSPLKFTYLPKISQNINRAKDWFAEAMEKHDYPGKYYYCYCTKSSHFRYVLHEALKNDIHIETSSAFDIDIVENLKAQGLISDRTYVICNGFKREAYVDNIGRLINEGHRNCIPIIDNYEELSLLDEVIDQPFKVGIRIASEEEPKFEFYTSRLGIGYKDIVPFYENQIRDNDKVELRMLHFFINTGIRDNAYYWNELNKCLKVYVRLKKLCPSLDSLNIGGGFPTKNSLSFQYDYAYMVDEIVNQIKLTCEEGDVPPPNIFTEFGSFTVGESGGAVYKVLYQKQQNDREKWNMIDSSFITTLPDSWAINKRFIMLSVNRWDDPYERVLLGGLTCDSDDYYNSQQDMNAIYLPKFHSGKPLYIGFFNTGAYQETIGGFGGLHHCLIPQPKHLLIDREENGEVFISVFSEQQTARDHMQILGYGPGPDGEPEAQTSLRTGKKRETAS
>NC_013222.1|WP_015753037.1|435742_436615_-|agmatinase
MKQSKNYAGIPDEFSQMEKAAVVLIPVPYDGTSTWGKGADKGPDAFLEASENMELYDIETGTEVYRQGIYLAPPVTGDHPEGVVNAVHDQVKDYIMRNKFVTLFGGEHSLSIGSIRAFNECFDDLTVLQIDAHADLRKTYEGTAYNHACAVHEASQTTNLVQVGIRSMDAIEKTYMDPEKVFFAHEMAADEFWMDKVIELLTDNVFITFDLDALDPSILPSTGTPEPGGLFWYETLEFLFRVFEEKNVVGFDIVELCPNPADRSSDFLAAKLYYKMLSYKFREDAIEGDA
>NC_013222.1|WP_015753036.1|434711_435686_-|deoxyhypusine-synthase-family-protein
MDSNAPVTDFITRYFRHFNAAALVDAAKGYQDQLDQGAKMLVSLAGAMSTAELGRIFAEMIRQDKVHIISCTGANLEEDIMNLVAHSHYRRVPEYRDLTPKDEWALLEKGLNRVTDTCIPEEEAFRRLQEHIFKIWKDAEAAGERYFPHEFMYKLLLSGVLEPHYEIDLKDSWMYAAAEKNLPLVCPGWEDSTMGNIFASYVVKGELKASTMKSGIEYMTYLADWYTDNSDKGIGFFQIGGGIAGDFPICVVPMLYQDLERTETPFWSYFCQISDSTTSYGSYSGAVPNEKITWGKLGIDTPKFIVESDATIVAPLIFAYLLNM
>NC_013222.1|WP_015753035.1|434400_434709_-|hypothetical-protein
MDNLKRVIVDFKKLTPEVLKLLVEKYPDGYDDDNIITFRNAQGERVEAVEVTTDDTKYLVKISAKLEKTMANYEEEDYEDFDDDDPEAIPDVEIDSEDDPEM
>NC_013222.1|WP_015753034.1|432946_434320_-|30S-ribosomal-protein-S6--L-glutamate-ligase
MTQLPTLGSEEWCVFDDLGIPAIKARVDSGAKTSSMQATNIKVVMKHGEEWVHFEVHPLQDTRSITIPCEAKLVDRRYVKSSSGITEERLVIRTPVRLGEDTFEIEVTLASRDTMEYRMLLGREALSGRYLVNPAASFSQQEISDAELEGLYKPHRPSRSGLKIALLASNPQLYSNKRIMEAAQGRGHEIVFLNVELAYMKLDARSPEIRYRGGNILNEFDAIIPRIKPAVTFYGCALIRQFDNLGVYCLNSAEAITQSRDKLFASQLFSRHDIHIPITGFAKSPNDTRDLIKMVNGAPLIIKLLESTQGKGVVLAETNKAAESVINAFKSVQTNILVQEFIKEANGQDIRCFVINNKVVASMQRQAEKGEFRANIHQGGSASPVKITSEERKLAIKAAKVLNLAVAGVDIIRSNKGPLLLEVNSSPGLEGIENATGKDIADSMIRAIEKKLNYQPA
>NC_013222.1|WP_015753033.1|432008_432959_+|NAD-dependent-epimerase/dehydratase-family-protein
MAKTILILGACGQIGTELTLALRGIHGPEAVVASDIREGDSELMGSGPFEILDATDADAMEEVVVHYEVDEIYLMAAMLSATAEKFPDRAWNLNMNTLFNVLKLARENKISKIFWPSSIAVFGGTTPKEDTPQSTVMEPSTVYGISKQSGERWCAYYHRKFGVDVRSLRYPGLISWKTQPGGGTTDYAVEIFHEALKNGTYTSFLDRDTRLPMMYMDDAIRATIELMRADAEALSIRSSYNLQAMTFSPEELAEAIRREIPDFRIEYAPDFRQEIADSWPSRIDDSQAREDWGWQPEYDLQKTTATMLAELRAQAG
>NC_013222.1|WP_015753032.1|431451_431946_-|hypothetical-protein
MKKLCAFFLLLCVLSGCDQPAGPRIDSPPEGTLPDTLPLPEPVGLQGPVRTAVADWEAFTALEERIASLYNVQGPEEMKLKLEELTADFQALEESEFPELFNIPSVRSRERVVRTFLLKTQAALYYRRDYRPALRQFLEAYNAFRSQLNRVESSQLDPSLFDED
>NC_013222.1|WP_015753042.1|442098_442764_+|ATP-binding-cassette-domain-containing-protein
MKTLHIDSVRKSYQNKVILSDIYLACKTGEIVGLLGRNGSGKSTLLKIIFGSERADNKFVRAGDRIIRNITDGRNLVNYLPQDNFLPRGVRIRTLFELFLTSKMNRHILEHEYVQPLLNKKNDELSGGEKRIVEILLLIHSNADFILLDEPFNGLSPKLCDYICEYIKQLAPTKGFIISDHDYTNIINPSDRIVVLKDGYLREIKDKAELVELGYLLESHL
>NC_013222.1|WP_015753044.1|443303_443747_+|hypothetical-protein
MKRQLFFGSFITLLCGGLIYVLFRTATLKMFVWYETIGLGGLINELRNWSFQFAGKLPEWILFSLPDGLWIFSYVCLMLAIWRNSFSFKNAIWILIIPILAISSEIGQYLGLVIGTFDFADLLFYIFGMTLPFIFFTKTINLKFQIK
>NC_013222.1|WP_083760671.1|443743_444292_+|DUF4352-domain-containing-protein
MKENLKHLISFMALAIFVFIAFGSMDDDSSSSSSSSSNSVSSDNSVTTKQVGETLSTQYFDVTINKVSLQDRVSTGNQFADLKKEEGNQYLVLNTTFKNTDDESRMIMDGEVLINYNGKEYLFDKSETVMLEGWGLMLDQINPLTSKTTNLVYKIPSEITGPAYYRPGRSNSDDLIVIGNIQ
>NC_013222.1|WP_148214270.1|444539_445070_+|hypothetical-protein
MNTANRGRKSTSQLELLRATVVFAHSTLEDFMRSIQAWKMPSTKSDHLNDVWLLENPRKTKFSIQEIYQFRSMKVEDLIEKSIKSYLDFQSYNQPTDLAKAIQSSGLTVSDEIKELFPKLAPLMSRRHHIVHQADRNNKVGSGHHKYKSLNLREVKDWISTIDSFAELLIIEIHNG
>NC_013222.1|WP_015753048.1|445062_445383_+|YegP-family-protein
MGKFEITQDKSGKFRFKLKARNGQIILSSQAYTTKSAAEKGIESVKINSNNISRIIRKRSNDGKFYFNLKAANGQIIGTSPLYNSKTGREGSIHTLKESKEVETST
>NC_013222.1|WP_187289181.1|445945_446920_+|beta-lactamase-family-protein
MEDFTAAVADFMANRGLKGGQVAITRNEKLVYLQSFGDADDETPVHDQSLFRVASISKPITVLAISRLVADGKLSMGDRVFGTNGLLGTQYGTPPYQDGVEKITVNELVEHKSGFKNEPYDIMFDEVSLSHQQLIDRVLDERTYVRSNPYYYSNFGYCLLGRVIEAVTGMSYEDYVEQKILSPMGISAMKIGGNTLDERFENEVLYNSSWFDPYAMNVTRMDAHGGWIASAKDLARIAVHSDTRSVVPDLLDFGDAESYLENGTYLHYGALPGTLAVLSVNSPFCYTAVFNTGNANYDSVLNAFADFMNDQITSRQEWPEADLF
>NC_013222.1|WP_041326902.1|446955_449055_-|helix-turn-helix-domain-containing-protein
MPDTPSKKEHFISRAETLLLENIARENFGVSELAEAMNMSRSSLLRKVRKHTGLSASQFIRQVRLKQGMEMLRQTTLNVTEVSYRVGFGSTSYFIKCFREHYGYPPGEAAERALENASAEPGDSPMEAGASAHGTPLTSAVKPRWKSIAAVALALGILAFLLYFLSRPPTSIEVEKSIAVLPFKNESSDTTNTYFVNGLMESTLNNLQKIEDLRVVSRPSVEKYRHSDKTIQEMAGELEVNYFIAGSGQREGDRVLLNIQLIEAATDRQIWAEQYSRELGDIFALQHEVAQKIAAAIEAIVTPAEREQIEKVPTENLAAYDYYLQALEPYHAGNGEGLLRAIGLFEQAIGEDPQFAQAYANMAIAYFLLDMDLAEKKYTDRINNLADKALLYDSKLAESLVAKALYYMQVKQYRLALPHLEKALEYNPNSVLVYQLLSDYYARIVPDTGKYLEYALKGNQLEFGAGDSITRSYSNLHLGNAFIQTGFPDQAMEYIDQSIAYFPQNEYASFVRVFIQFAIDRDLGRMQRSLVREWQKDTTRLDILQEVGKSFYFQEEYDSAYYYYGKFVRAREGSGLDIYPQEDLKIGRVFEAVGRPEMAGEFYRSYAAYCERDESIYKPASLAVKYAHEGKLDQAIEQLEVFAAQDNFQYWILLFIEKDPVMEPLEGHPGYAAVLQKIRDRFWAHHERLEKELEQEGLL
>NC_013222.1|WP_015753051.1|449236_449806_+|ankyrin-repeat-domain-containing-protein
MKTLKIKPLKSLIYTAFLGALLISSAGSCQDAKSQTGVARPEMDIHTAVLYGNLDAVKQHVAAGTDLDSQDPMGGYPLIAAATFGHTEIAETLIDGGADISVTNNDGSTALHAAAFFCRVEIVQALLDANADKTVRNKFGSTPRESVMGSFSDVKPIYEMMQSQLGALGLKLNMEELEETRPVIAMMLQ
>NC_013222.1|WP_041326903.1|449826_450930_+|acyltransferase-family-protein
MTPQRRYDIDWLRVIAIGLLLVYHIAIIFQPWAMLVGFIGTEEPLEAIWKPMTLLNVWRIPLLFYVSGMGVCFAIRKRNWLQLLRERSQRILLPFVFGFLAIAPLHFLVFQEYYGLPLGYYPHAGHLWFLGNIFCYVLLLSPLFFYLKKHEEGRFVQKLRYLMRKAVGPLSVISFFVIEALLVRPRPFELYAETWHGFFIGLLAFFFGFLFVLIGKPFWQTVLKWRWLYIGLAASLYTLRFLEFNLSAPGYLMAIESNLWIFGIFGFGYKYLNRPGATLRYLSQAAYPVYIIHMAVLYTAAMLILPLELSPFLKFLGITVFTGVICMLLYEFVIRRIGFLRPLFGLKVKAGTETRKPVLPKSAGTME
>NC_013222.1|WP_015753053.1|450956_451580_-|RidA-family-protein
MKRTVWAFIALALTLSCNGPSNTHDTPADPSAGSGSQSAESGAMRDAADSPDPDFDPETRLAELGIDLPEAATPVANYVNAVRSGNLIFLAGKGPKKADGTYITGQVGTDLTEEEGYEAARLTAINQLAVLKAELGNLDRVVRIVKVHGMVNAAPGFTNQPEVINGFSDLMVAVFGDRGKHARAAVGMGSLPRNISVEVEAVVEVRD

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Crispr_ID: NC_013222_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013222_3

921305-921681

Orphan

Consensus_repeat	Method
CATCGTCCTTGTCGGCAACGCCGTCTCCGTCAGCATCGGGGCATCCG	CRISPRCasFinder

4 spacers

The CRISPR arrays of NC_013222_3

>merge|NC_013222|3|921305-921681|CRISPRCasFinder
CGTCGTCTTTGTCGAGGACACCGTCGCCGTCAGTATCCGGCCAGGGGCATCCGTTGTTTTCAGCAGGACCTGCTTCAGAAGGACACTCATCGTCCTTGTCGGCAACGCCGTCTCCGTCAGCATCGGGGCATCCGGAAAGAGCCGGCAGACCAGCTTCGTTCGGGCAGGCATCGTCCTTGTCGGCAACACCGTCTCCGTCAGCATCGGGGCATCCGTTCATCTCCATGGATCCGGCCTCGTTCGGGCAGGCATCCTTGGCATCTTCGATTCCGTCTCCGTCAGAATCCGGGCAACCGTTAAAGGCTTCCAGTCCGGCAACTTCGGGGCAGGCATCGTCTTTGTCGTAGATACCGTCACCGTCCGTGTCGGTTCCGCCA

>NC_013222|3|3|921305-921681|CRISPRCasFinder
CGTCGTCTTTGTCGAGGACACCGTCGCCGTCAGTATCCGGCCAGGGG	CATCCGTTGTTTTCAGCAGGACCTGCTTCAGAAGGACACT
CATCGTCCTTGTCGGCAACGCCGTCTCCGTCAGCATCGGGGCATCCG	GAAAGAGCCGGCAGACCAGCTTCGTTCGGGCAGG
CATCGTCCTTGTCGGCAACACCGTCTCCGTCAGCATCGGGGCATCCG	TTCATCTCCATGGATCCGGCCTCGTTCGGGCAGG
CATCCTTGGCATCTTCGATTCCGTCTCCGTCAGAATCCGGGCAACCG	TTAAAGGCTTCCAGTCCGGCAACTTCGGGGCAGG
CATCGTCTTTGTCGTAGATACCGTCACCGTCCGTGTCGGTTCCGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_013222.1\|WP_015753489.1\|930116_931043_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|238921
NC_013222.1\|WP_015753485.1\|923561_926681_-\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|224000
NC_013222.1\|WP_015753491.1\|931776_932355_-\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|187714
NC_013222.1\|WP_015753482.1\|918089_920825_-\|PD-(D/E)XK-nuclease-family-protein	unknown	unknown	gnl\|CDD\|378929
NC_013222.1\|WP_015753479.1\|915735_916533_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_013222.1\|WP_015753476.1\|913048_913822_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|223955
NC_013222.1\|WP_015753493.1\|934111_934849_+\|ribonuclease-III	unknown	unknown	gnl\|CDD\|274024
NC_013222.1\|WP_015753484.1\|922365_923559_-\|glycine-C-acetyltransferase	unknown	unknown	gnl\|CDD\|235893
NC_013222.1\|WP_015753474.1\|910576_911032_-\|6-carboxytetrahydropterin-synthase	unknown	unknown	gnl\|CDD\|376501
NC_013222.1\|WP_041326975.1\|926794_927403_+\|superoxide-dismutase	unknown	unknown	gnl\|CDD\|223678
NC_013222.1\|WP_015753492.1\|932853_934104_+\|beta-ketoacyl-ACP-synthase-II	unknown	unknown	gnl\|CDD\|274452
NC_013222.1\|WP_015753481.1\|917375_918086_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235990
NC_013222.1\|WP_015753480.1\|916562_916991_+\|hypothetical-protein	unknown	unknown	unknown
NC_013222.1\|WP_015753478.1\|915168_915681_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_013222.1\|WP_041327478.1\|909748_910507_-\|UDP-2,3-diacylglucosamine-diphosphatase	unknown	unknown	gnl\|CDD\|277343
NC_013222.1\|WP_015753477.1\|913837_915172_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240541
NC_013222.1\|WP_148214289.1\|911104_912964_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224055
NC_013222.1\|WP_009778413.1\|932507_932741_+\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|179197
NC_013222.1\|WP_015753488.1\|928179_930078_-\|amidophosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223112
NC_013222.1\|WP_015753490.1\|931148_931784_-\|ribonuclease-H-family-protein	unknown	unknown	gnl\|CDD\|260015

Protein	Function_ID	Function_description	E-value
NC_013222.1\|WP_015753489.1\|930116_931043_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|238921	cd01946, ribokinase_group_C, Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.	9.60015e-144
NC_013222.1\|WP_015753491.1\|931776_932355_-\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|187714	cd08645, FMT_core_GART, Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART). Phosphoribosylglycinamide formyltransferase, also known as GAR transformylase or GART, is an essential enzyme that catalyzes the third step in de novo purine biosynthesis. This enzyme uses formyl tetrahydrofolate as a formyl group donor to produce 5'-phosphoribosyl-N-formylglycinamide. In prokaryotes, GART is a single domain protein but in most eukaryotes it is the C-terminal portion of a large multifunctional protein which also contains GAR synthetase and aminoimidazole ribonucleotide synthetase activities.	5.98502e-80
NC_013222.1\|WP_015753482.1\|918089_920825_-\|PD-(D/E)XK-nuclease-family-protein	gnl\|CDD\|378929	pfam12705, PDDEXK_1, PD-(D/E)XK nuclease superfamily. Members of this family belong to the PD-(D/E)XK nuclease superfamily.	1.32517e-22
NC_013222.1\|WP_015753479.1\|915735_916533_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.75507e-14
NC_013222.1\|WP_015753485.1\|923561_926681_-\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|224000	COG1074, RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair].	2.59428e-76
NC_013222.1\|WP_015753493.1\|934111_934849_+\|ribonuclease-III	gnl\|CDD\|274024	TIGR02191, Ribonuclease_3, ribonuclease III, bacterial. This family consists of bacterial examples of ribonuclease III. This enzyme cleaves double-stranded rRNA. It is involved in processing ribosomal RNA precursors. It is found even in minimal genones such as Mycoplasma genitalium and Buchnera aphidicola, and in some cases has been shown to be an essential gene. These bacterial proteins contain a double-stranded RNA binding motif (pfam00035) and a ribonuclease III domain (pfam00636). Eukaryotic homologs tend to be much longer proteins with additional domains, localized to the nucleus, and not included in this family. [Transcription, RNA processing].	8.41445e-56
NC_013222.1\|WP_015753484.1\|922365_923559_-\|glycine-C-acetyltransferase	gnl\|CDD\|235893	PRK06939, PRK06939, 2-amino-3-ketobutyrate coenzyme A ligase; Provisional.	0
NC_013222.1\|WP_015753476.1\|913048_913822_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|223955	COG1024, CaiD, Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism].	7.66486e-37
NC_013222.1\|WP_015753474.1\|910576_911032_-\|6-carboxytetrahydropterin-synthase	gnl\|CDD\|376501	pfam01242, PTPS, 6-pyruvoyl tetrahydropterin synthase. 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.	4.43809e-32
NC_013222.1\|WP_015753492.1\|932853_934104_+\|beta-ketoacyl-ACP-synthase-II	gnl\|CDD\|274452	TIGR03150, fabF, beta-ketoacyl-acyl-carrier-protein synthase II. 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis (GenProp0681). The large gap between the trusted cutoff and the noise cutoff contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cutoff of this model. [Fatty acid and phospholipid metabolism, Biosynthesis].	0
NC_013222.1\|WP_015753481.1\|917375_918086_+\|SDR-family-oxidoreductase	gnl\|CDD\|235990	PRK07326, PRK07326, SDR family oxidoreductase.	1.11664e-156
NC_013222.1\|WP_041326975.1\|926794_927403_+\|superoxide-dismutase	gnl\|CDD\|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	5.37101e-111
NC_013222.1\|WP_015753478.1\|915168_915681_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.2198e-17
NC_013222.1\|WP_041327478.1\|909748_910507_-\|UDP-2,3-diacylglucosamine-diphosphatase	gnl\|CDD\|277343	cd07398, MPP_YbbF-LpxH, Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain. YbbF/LpxH is an Escherichia coli UDP-2,3-diacylglucosamine hydrolase thought to catalyze the fourth step of lipid A biosynthesis, in which a precursor UDP-2,3-diacylglucosamine is hydrolyzed to yield 2,3-diacylglucosamine 1-phosphate and UMP. YbbF belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.08728e-57
NC_013222.1\|WP_015753477.1\|913837_915172_-\|MATE-family-efflux-transporter	gnl\|CDD\|240541	cd13136, MATE_DinF_like, DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.3996e-96
NC_013222.1\|WP_148214289.1\|911104_912964_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.26609e-100
NC_013222.1\|WP_009778413.1\|932507_932741_+\|acyl-carrier-protein	gnl\|CDD\|179197	PRK00982, acpP, acyl carrier protein; Provisional.	6.26249e-32
NC_013222.1\|WP_015753488.1\|928179_930078_-\|amidophosphoribosyltransferase	gnl\|CDD\|223112	COG0034, PurF, Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism].	4.3895e-48
NC_013222.1\|WP_015753490.1\|931148_931784_-\|ribonuclease-H-family-protein	gnl\|CDD\|260015	cd13935, RNase_H_bacteria_like, RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. This family includes bacterial ribonuclease H (RNase H) enzymes. RNases are divided into two major families, Type 1 and Type 2, based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication, repair and transcription. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. RNase H inhibitors have been explored as an anti-HIV drug target because RNase H inactivation inhibits reverse transcription.	2.00704e-69

>NC_013222.1|WP_015753482.1|918089_920825_-|PD-(D/E)XK-nuclease-family-protein
MQSFLDSVLDDLPEWQSDPSSFVFVLPSKRAGFFLKNRMAQRATSTFLSPHIWSIEDFVAEISGLRYAGTLHLLFRLYEACLDQEGIQQESFADFTKWGPTLLQDFNEADRYLVDTDRLFETLAALNEIRNWTPDGSSTPMMDRQIAFWKNLAPIYSRFRTNLAGEGLAYQGMAYRAAASQLASYAAARGDVRYIFIGFNALNTAEDRIIQQLLEKPGSRIYWDADPHYIDNPVHDAGHFMRKHLRDWPSLRTGLAGIQNHFASPRNIRMVGIPKSVAQAKYCGSLLGELYAEDPEGIENTALVLGDEALLTPVLHALPAEIPAVNITMSYPIRHSPMAQLFDLLLEMRIRKTAEGWRVPQLLVLIAHPYLQSWFRSLDFEPTRGRMYLIRENLYYADSDALEAMGLPVTVRELLLPPPGAPPSDHAKNLEDITRALKPVYQKAGDPLQLEYLFHFNQLFNQLIQLTGAYPFVSDLKSLQLLYRQLLADEKVDFEGQPLSGLQVMGMLESRNLDFDTVIITSVNEGILPSGKSNASFIPFDVKREFGMPTYKEKDAVYTYHFYRLLQRARRVVICYNTEPEVIEGGEPSRFINQLRTDPVLGPQTELAFAVPETGAERPGELRIHKGPELLERLQEMASSGFSPTSLSRFIADPLLFYQRNVLGLDETEELEETVAANTFGTVLHDALEELYRPLEGAFLNRDNLAELRNRSDSAIERAFRKNYLRDGKARGKNLIALQVLRQHLDHFLGSEVTRAEKHRIRILGVEKKFRQELAVPGLQHPVTLKGTVDRIEEVDGQVRIVDYKTGKVTPAELRVSEWESLRTEPDRAKAFQVLCYALLYAGDSGTLPEKAGVVSFKNLGAGYQWFGVRTAPRQTEEQIHADTLTAFREVLHELLLEVFNPAVPFEARPA
>NC_013222.1|WP_015753481.1|917375_918086_+|SDR-family-oxidoreductase
MDQLKDKVAYITGGSKGIGYGIAQSLLAAGMRVAISGRDKKRIEEAAASLDRERVIPIVSDVTRLEDEEEAVKTILYRWGQVDAVIANAGLGHFAPVDELSPDHWKQMIDTNLTGVFHTLKAALPALKESRGYYITVASLAGTNFFASGAGYNATKFGVVGFTQAAMLDLRPFDIKVSTIMPGSVATHFNNNEPSEKDAWKIQPEDLGELVLDLLKMHPRTLPSKIEVRPSRPDNK
>NC_013222.1|WP_015753480.1|916562_916991_+|hypothetical-protein
MRKILVCTLLFFYYPSFSQTLTDESDKEELTYVLSNIQRTVEGHKSIFDGAFYFRVYQIWDSRGTPEGTFPGSEEAYSAYYIAVSPDGDYYVGAELFKVGGLIAPEWLGIEPQQYPEVKIRFRHGPHNQRKVVEYVLRPEIR
>NC_013222.1|WP_015753479.1|915735_916533_+|universal-stress-protein
MKKILVPVGNPESALETLKYAVSFGAEFKAEIYAMEVLTKTSRAGELSNVKEKFVESSKERLRELIGQIDTGGVDVKVATYQGDLVDGLNNLTAELDIDLILVAPRSVEIDEELYLGNTTGRIIKRTNIPTLIVPKGCSFKPYKTILTAFRSGILKRKRVLKPLVAIQEKFGATVNLLMVKTPNYTDDDLKINTALMDIASQVTMTEHANTYLGVLEHLQSQQPDLLTVFRRKRGFFNALWEKNTIQKSEFSARIPVLVLSVKKD
>NC_013222.1|WP_015753478.1|915168_915681_-|GNAT-family-N-acetyltransferase
MIRPAKVEEIPEIMEMARACGRAMQANGIFQWTDVYPKREAFVRDLDRGELWVIDAGHGPVGTIVVSSRMDEEYKSVRWLTPNRDNLYIHRLGVHPDYQRQGLAQQLMDHAEGLALRQGARSIRLDTFSRNHRNQRFYEQRGYQRLGAVYFPRQSAYPFYCYERVVNSQV
>NC_013222.1|WP_015753477.1|913837_915172_-|MATE-family-efflux-transporter
MNPALSRKNINRLAIPAIFAGIAEPVLSITDTAIVGNIPENGLESLAAVGIVGSFLSMLIWILGQTRSAVSAIVAQYVGGDRLDDIKTLPAQAIFLNLALSLLILGVSLPLSPQIFGLLNAEGLILEYCISYFQIRVWGFPLTLLTFAIMGIFQGLQNTGWPMLIAITGAGLNILLDFALVYGVDRWIPAMNLEGAAWASLIAQGVMALLALGLLMWRTPIRLKLQFPVHPEMRRLIGMVLNLFIRTLSLNLALLLAVREATALGDRFIGAHTIAINLWLFAAFFVDGYSSAGKILGGRFLGAKDYDSLWNLAKKLSRYGLGVCLFLMVAATVFYRPTGRLFSEDVLVLQAFYSFFFILILGMPINGIAFVFDGIFKGMGKMRFLRNVLLFATFLGFVPALYLGKVLDWGLYGIWGAFTVWMLFRGAPLVWKFRQKFRPLLQKA
>NC_013222.1|WP_015753476.1|913048_913822_-|enoyl-CoA-hydratase/isomerase-family-protein
MTAARKEGSLYTQRSGPLARVEFGHPASNSFTSNLLSRLEREIDALGGDGDISVILLQSEGDRAFCAGASFDELLEIDNPETGAEFFSGFARVINAMRRCPKPIVARVHGKAVGGGVGLIAACDYALALEGASVRLSEISIGIAPLVIAPAVARKTGAAGLAELSLSPTEWKSAYWAQEKGLYARVFDSRQALDEEAEFFASQLASYPPAALTALKKALWEGTDHWGDLLPERAAETGRLALSETTQETLRKFKEKK
>NC_013222.1|WP_148214289.1|911104_912964_+|ATP-binding-cassette-domain-containing-protein
MRKLPKKALAAKRLKSIADQERISLRDSFRGWQSIPRFFREIYAAGPRLFILNLLGRLLKGFSPVVLLWIGKVIIDEIVFLLNNPDGDFTRLWTYVAIELGVALLTDLIGRGVTLTDGLLGDLYSNASSERIIHKAADLSMSQLENPVFYDKLERARMQTNSRVSLMSNVLAQGEGLLSIISLIAGLIYFEPWLILLLILSIVPAFINELKFSSDRYSLARSWTSERRELDYLRYIGANNRTAQEVKLFGLTGFIAGRFRDMAAQYYRLTRRLAVRQSLFGGLFNLLGVIAYYGAYILIIYRTLGGLLTLGELTFLSGSFNRLQTNMQGFFSRFTRISESALYLKDYFDFIDLEPESPGGDVVPMPDRIREGFEFREVYFTYPESDTPVLKGVSFRIRAGEKIAFVGQNGAGKTTLIKLILQFYQPTSGQILLDGTDISRFDKEAYRKRFGVIFQDYFRYEFTLRENIAVGDIGAVRDDTRIGEAARKSLADQVVQEMADGLEQQLGRRFARGQELSGGQWQKVALARAYMKDADVMVLDEPTASLDARAEYEVFERFIGLTRGRTSIIISHRFSTVRMADRILVLEDGVVTALGTHEDLMEQGGLYAELFTLQAAGYQ
>NC_013222.1|WP_015753474.1|910576_911032_-|6-carboxytetrahydropterin-synthase
MARVRITKEFTFETGHALYGYDGKCRNVHGHSYHLSVTVIGTPIAEDGAVKLGMVMDFGDLKKVVREEVVDRFDHATIFNRNTPHVELARTLEREGHRVILADYQPTSENMVVDFAHRISKRLPEHIRLHSLRLRETGTAYAEWFASDNPD
>NC_013222.1|WP_041327478.1|909748_910507_-|UDP-2,3-diacylglucosamine-diphosphatase
MAIPGGKKVYFASDNHLGAPNSRESLVRERRFVAWLDSIREDAAAIFLLGDLFDFWFEYKRVVPKGFTRTLGALASLTDQGIPVIYFVGNHDLWMDGYFEEELNIPVYHKPRVFEIGGKRFFIGHGDGLGPGDKGFKRMKKVFTNPVAQWAFRWLHPDLGVRMAQYFSVKNKMISGEEDVRFLGEDREWLVQYARRKLTEAHFDYFVFGHRHLPLDIKLTDSSRYVNLGDWISHYSYGVFDGETLKLEYYRQ
>NC_013222.1|WP_015753484.1|922365_923559_-|glycine-C-acetyltransferase
MYGKIQEHLKNELEDIRQAGLFKEERVITSAQGPVIRISTGQEVLNFCANNYLGLSAHPEVVRAAKDTLDSHGFGMSSVRFICGTQDIHKKLEQTIADFYGTEDTILYAAAFDANGGVFEPLLGPEDAIISDSLNHASIIDGVRLCKAMRYRYANADMASLEEQLQKAQEDGARFKVIVTDGVFSMDGLLAPLDEICDLAEKYDALVMIDECHATGFIGETGIGTLEEKGVLGRIDIITGTLGKALGGAMGGYTTGKKEIIEMLRQRSRPYLFSNSLAPAIVGASIKVFELLSRDDSLKKTLDRNTAYFKKGMKALGFDIVDGESAIVPVMLYDAKLSQEMAERLLEKGIYVIGFFYPVVPKGKARIRVQLSAAHELEHLDRAIMAFKEVGRDLGVI
>NC_013222.1|WP_015753485.1|923561_926681_-|UvrD-helicase-domain-containing-protein
MTPPGEAFRIYSASAGSGKTYTLTREYLKLLLSGQGGQPFREILAITFTNKAVGELKNRILDSLEAFAGVRDEAGRPVLFRDLQDELGTDRETLARRSGRVLQEILHNYAFFDVSTIDRFNHRILRTFARDLQLPANFEVVLDTDALLEQAVENLILQAGEVPALTRVLIDYALEKSADDRSWDIARDLADTGKLLFNENHREYLDTFRGKGMADFVRLRESLAAMRDECEADLLRTTSEILRVIENNELERLDFSRGYFPDFIRKVNAGDFDQNFDAAWKREFAEKPLYSKKTPEDTKALLDGLHPEFARQFETIRLRIYQRAFLSNAYQNSAPFTVLGLLQLELQRIQEADSLLPVARFNSIIAEELAGQPAPYIYERLGEKYRHYFIDEFQDTSELQWKNLVPLIGNALEGEDQQGRHGSLVLVGDVKQAIYRWRGGKAEQFLGLIQGPGNPFSIDPTRAPLEKNFRSSQTIVDFNNDFFSVLSSRLSNEAYSRLFLDGNRQLAHSRQPGWVEIQFQDPDAADSETAYLDRTVEILERLRGEGYRLGDICVLTRRRKDGVALSDRLLAEGIPVISSETLLLANHPTVRFLVDLLRLLQDPSDPNHAYGVLSFLAPAGAGTHAWIRNHLGDTGELLVQEWSFDPGVMRLKPAYDILEEAIRNFRLGGAADAYLFALLEHALDASRNGDVSPGTFLEYWDSKKDKLSIAAPENPDALRLMTIHSAKGLEFPVVIFPFADSQIYGGKNPKLWLPVDPESFCGFSYLQISSRKEVEHYGAAAAACYREEREKLELDAFNVLYVAHTRAIHALFVLTGKAPDGETREPARYTDLYASYLRATGKWEDATCTYTFGSPAPAPGHREFPVRSPLPLGYSSRDAGRLRVVTRSGRLWDSAQEAAAAYGNTLHLALSLIRTAADLPGVIPRLVGEGLLPAEEKESLARLLEQVVHHPELAPYFEEGAEIYNERDIILRNKVILRPDRLVIQEGRAVIIDYKTARPAPGHRDQLRGYASAIEEMGLKIDRALLVYITDNGIQTETL
>NC_013222.1|WP_041326975.1|926794_927403_+|superoxide-dismutase
MAFQLPNLPYAYDALEPHIDARTMEIHHTKHHNGYTTKLNNAIEGTDLDGKSIEDILKNLDMGNGAVRNNGGGYFNHSLFWEILSPDGGGKPSGDLASAIDDAFGSFDKFKEAFSNAAATRFGSGWAWLCVHPGGKVEVCSSPNQDNPLMPGVGCGGYPILGIDVWEHAYYLNYQNRRPDYIEAFFNLINWSKVSENFAAHK
>NC_013222.1|WP_015753488.1|928179_930078_-|amidophosphoribosyltransferase
MSDAIKHECGISLIRLLKPLEYYQEKYGSAFYGVNKMYLMMEKQHNRGQDGAGFASIKLDMRPGERYMSRVRSNASQPIQDIFDQINARINTSLKEHPEAVNDVAWQKRNIPYVGELLLGHVRYGTFGKNSIESVHPFLRQNNWMHRNLIVAGNFNMTNVNELFDNLVQLGQHPKELADTVTVMEKIGHFLDDAVAKIYKQIKKEGYTKMEASPMIAERLKVSKILRKSSKNWDGGYAMAGLLGHGDAFVLRDPSGIRPVYHYADDEVVVVASERPAIQTVFNTAYEEVQELPPGHAIIVKKDGDVRIRQIQEPRERKACSFERIYFSRGNDKEIYQERKELGKLLFPQILEAIDHDIKHTVFSYIPNTAETSFLGMLREAQNYLNKKKEEQILALGPDITSEELHNILEVRPRIEKVAIKDAKLRTFITQDSSRDDLVAHVYDISYGSVNKGDYLAIIDDSIVRGTTLKKSILRILDRLGPRKIIVISSAPQIRYPDCYGIDMAKLEDFIAFRAALELHRERGSMDVVDSIYEKCKEQLANPEREAVNHVKEFYAPFRTQELSDKIAELLSPPEIRAEVQIIYQTISNLHKACPDNLGDWYFTGDYPTPGGNRVVNQAFVNFHEGKNQRAY
>NC_013222.1|WP_015753489.1|930116_931043_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MGKLLIVGSVAFDAIETPFGKTDKILGGAAPFIGLAASHYRADSAIVSVVGEDFPASYLDLLRERGIDVSGIEVVPGGKTFFWSGRYHNDLNMRDTLVTELNVMADFQPVVPEAYRDADIVMLGNLHPDIQLSVIGQMDSRPKLTVLDTMNYWMDNTLDTLLQVIGKVDVITINDEEARQLSGEYSLVKAAEAIHEMGPRYVVIKKGENGALLFNDSRIFFAPALPLEEIFDPTGAGDTFAGGFTGYLAQTQNISFNNLRNAVIHGSNLASFCVERFGTERLIQLRPQDIDQRLERFRELTQFDIEVK
>NC_013222.1|WP_015753490.1|931148_931784_-|ribonuclease-H-family-protein
MAEKNKFYVVWKGKKPGVYTSWEACKKQIQGEKGAQYMGFPSRGQAEMAYRAGYREAVARKKRAKGVSPEQLARVGRPNPNSISVDAASSGNPGVMEYQGVDTRTGKRLFHQGPFRQGTNNIGEFLAIVHALAYLKKQGSNRIIYSDSRTAMSWVRKKKCNTKLEETETNRDLFDMVRRAVHWLETNSYETPVVKWETRAWGEIPADFGRK
>NC_013222.1|WP_015753491.1|931776_932355_-|phosphoribosylglycinamide-formyltransferase
MPKNIILFASGSGSNAENLTKYFERDPRVRIRAVLGNNLQAGVVERCKRLGLPFYGFNRAAFEDPGGFVGVLRSFDPDLIVLAGFLWKVPGEVVRAFPDAIINIHPALLPAYGGKGMYGMHVHRAVVQDGAKRTGITVHYVNEAYDEGAVIMQQEIPVTSGDTPESVAEKVHALEYEYFPKAVESVLFPGHG
>NC_013222.1|WP_009778413.1|932507_932741_+|acyl-carrier-protein
MSDIASRVKAIIVDKLGVDENEVVAEASFTNDLGADSLDTVELIMEFEKEFDIQIPDDQAENIATVGQAISYIEEAK
>NC_013222.1|WP_015753492.1|932853_934104_+|beta-ketoacyl-ACP-synthase-II
MQLRRVVVTGLGALTPIGNSKDAYWEGLKNGKSGCAPITYFDTEKFKTKFACELKGYDPMEFFDRKEVRKLDPFAQYALVCSDEAIADAGLDLDSVDKFRVGVIWGAGIGGLETFQTEVLNFAEGDGTPRFNPFFIPKMIADIAPGNISIKHGFMGPNYTTVSACASSANAMIDALNYIRLGHCDVVVTGGSEAAVTIAGMGGFNAMHALSTRNDSPETASRPFDATRDGFVLGEGGGSLILEDYEHAKARGAKIYAEVVGGGLSSDAYHMTAPHPDGIGVVRVMENCLRDAGISPEEVDAINTHGTSTPLGDVAELKAISQVFGEHAPKMNINSTKSMTGHLLGAAGAIEAIASILAMEHGIVPPTINHSVVDENIDPKLNLTLNKAQKRDVQVAMSNTFGFGGHNACVLFKKIS
>NC_013222.1|WP_015753493.1|934111_934849_+|ribonuclease-III
MTFPGNIFNSHPKEDGDFFLGISRILGFKPKSLEVYKRAFLHRSVNKKDKNGHPMNYERLEFLGDSMLGTIISKHLYNEVPAGDEGYLTKMRSKIVSRKHLNELGKDLGLLNFVESRIPKAHFGENIHGNVFEALVGAIYLDRGYKYCEKFIQSRVIEPYVDIEQLEGQVISYKSLVIEWCQKQKKEFEFEVYEDTGNDPVKHFAVKLHIDGRILAKARATSKKKAEEKASRRAFFALQNKMDSE

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Crispr_ID: NC_013222_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013222_4

2963072-2963154

Orphan

Consensus_repeat	Method
ATCGACGAGAACGGGGTGGACAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013222_4

>merge|NC_013222|4|2963072-2963154|CRISPRCasFinder
ATCGACGAGAACGGGGTGGACATTGACCTGAAGGACGAACAGGACAGTTTTAAGATGAAAATCGACGAGAACGGGGTGGAGAT

>NC_013222|4|4|2963072-2963154|CRISPRCasFinder
ATCGACGAGAACGGGGTGGACAT	TGACCTGAAGGACGAACAGGACAGTTTTAAGATGAAA
ATCGACGAGAACGGGGTGGAGAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_013222.1\|WP_187289173.1\|2954313_2955570_+\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224938
NC_013222.1\|WP_049764901.1\|2960635_2960983_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379639
NC_013222.1\|WP_015755357.1\|2970592_2973100_-\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NC_013222.1\|WP_041327259.1\|2961093_2961429_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_013222.1\|WP_015755354.1\|2966932_2967910_-\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NC_013222.1\|WP_015755341.1\|2955563_2956172_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|184971
NC_013222.1\|WP_041327263.1\|2968126_2969866_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|379862
NC_013222.1\|WP_015755346.1\|2960009_2960492_+\|DUF4870-domain-containing-protein	unknown	unknown	gnl\|CDD\|378240
NC_013222.1\|WP_041327261.1\|2963321_2964044_+\|DUF2807-domain-containing-protein	unknown	unknown	gnl\|CDD\|371327
NC_013222.1\|WP_015755356.1\|2969862_2970588_-\|membrane-protein	unknown	unknown	unknown
NC_013222.1\|WP_015755345.1\|2959419_2959875_-\|DUF4442-domain-containing-protein	unknown	unknown	gnl\|CDD\|373120
NC_013222.1\|WP_015755352.1\|2965219_2966287_+\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223234
NC_013222.1\|WP_041327258.1\|2958037_2958844_-\|TIGR00266-family-protein	unknown	unknown	gnl\|CDD\|376704
NC_013222.1\|WP_015755339.1\|2953954_2954152_-\|hypothetical-protein	unknown	unknown	unknown
NC_013222.1\|WP_015755344.1\|2958970_2959348_-\|hypothetical-protein	unknown	unknown	unknown
NC_013222.1\|WP_015755359.1\|2973764_2974322_-\|DUF3347-domain-containing-protein	unknown	unknown	gnl\|CDD\|378730
NC_013222.1\|WP_015755351.1\|2964158_2965178_+\|dipeptide-epimerase	unknown	unknown	gnl\|CDD\|239435
NC_013222.1\|WP_041327262.1\|2966397_2966838_+\|hypothetical-protein	unknown	unknown	unknown
NC_013222.1\|WP_041327853.1\|2973176_2973713_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378964
NC_013222.1\|WP_015755342.1\|2956345_2957932_+\|M81-family-metallopeptidase	unknown	unknown	gnl\|CDD\|377823

Protein	Function_ID	Function_description	E-value
NC_013222.1\|WP_015755341.1\|2955563_2956172_-\|NUDIX-domain-containing-protein	gnl\|CDD\|184971	PRK15009, PRK15009, GDP-mannose pyrophosphatase NudK; Provisional.	1.2017e-65
NC_013222.1\|WP_015755346.1\|2960009_2960492_+\|DUF4870-domain-containing-protein	gnl\|CDD\|378240	pfam09685, DUF4870, Domain of unknown function (DUF4870).	2.36225e-32
NC_013222.1\|WP_015755357.1\|2970592_2973100_-\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_013222.1\|WP_041327259.1\|2961093_2961429_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	3.66693e-21
NC_013222.1\|WP_015755354.1\|2966932_2967910_-\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	9.47338e-145
NC_013222.1\|WP_041327263.1\|2968126_2969866_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|379862	pfam16576, HlyD_D23, Barrel-sandwich domain of CusB or HlyD membrane-fusion. HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.	7.8387e-83
NC_013222.1\|WP_049764901.1\|2960635_2960983_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379639	pfam14534, DUF4440, Domain of unknown function (DUF4440).	1.02226e-20
NC_013222.1\|WP_041327261.1\|2963321_2964044_+\|DUF2807-domain-containing-protein	gnl\|CDD\|371327	pfam10988, DUF2807, Putative auto-transporter adhesin, head GIN domain. This bacterial family of proteins shows structural similarity to other pectin lyase families. Although structures from this family align with acetyl-transferases, there is no conservation of catalytic residues found. It is likely that the function is one of cell-adhesion. In Structure 3jx8, it is interesting to note that the sequence of contains several well defined sequence repeats, centred around GSG motifs defining the tight beta turn between the two sheets of the super-helix; there are 8 such repeats in the C-terminal half of the protein, which could be grouped into 4 repeats of two. It seems likely that this family belongs to the superfamily of trimeric auto-transporter adhesins (TAAs), which are important virulence factors in Gram-negative pathogens. In the case of Parabacteroides distasonis, which is a component of the normal distal human gut microbiota, TAA-like complexes probably modulate adherence to the host (information derived from TOPSAN).	1.50363e-50
NC_013222.1\|WP_015755345.1\|2959419_2959875_-\|DUF4442-domain-containing-protein	gnl\|CDD\|373120	pfam14539, DUF4442, Domain of unknown function (DUF4442). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 139 and 165 amino acids in length. There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.	1.16569e-05
NC_013222.1\|WP_015755352.1\|2965219_2966287_+\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	3.72938e-32
NC_013222.1\|WP_041327258.1\|2958037_2958844_-\|TIGR00266-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	7.17903e-84
NC_013222.1\|WP_187289173.1\|2954313_2955570_+\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224938	COG2027, DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane].	2.04512e-40
NC_013222.1\|WP_015755359.1\|2973764_2974322_-\|DUF3347-domain-containing-protein	gnl\|CDD\|378730	pfam11827, DUF3347, Protein of unknown function (DUF3347). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 169 to 570 amino acids in length.	5.89986e-50
NC_013222.1\|WP_015755351.1\|2964158_2965178_+\|dipeptide-epimerase	gnl\|CDD\|239435	cd03319, L-Ala-DL-Glu_epimerase, L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of the murein peptide of peptidoglycan, of which L-Ala-D-Glu is a component. L-Ala-D/L-Glu epimerase is a member of the enolase-superfamily, which is characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	1.5666e-108
NC_013222.1\|WP_041327853.1\|2973176_2973713_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|378964	pfam12833, HTH_18, Helix-turn-helix domain.	1.38541e-14
NC_013222.1\|WP_015755342.1\|2956345_2957932_+\|M81-family-metallopeptidase	gnl\|CDD\|377823	pfam07364, DUF1485, Metallopeptidase family M81. This is a family of proteobacterial metallo-peptidases.	2.93337e-127

>NC_013222.1|WP_041327259.1|2961093_2961429_+|PadR-family-transcriptional-regulator
MNVENTKAQMRKGVLEYCILSILSGEDKYASEILDTLKDAKMLVVEGTIYPLLTRLKNAGLLSYRWEESTSGPPRKYYGLTETGTIFLKELNTTWDELRTAVNVVTNAKNK
>NC_013222.1|WP_049764901.1|2960635_2960983_+|nuclear-transport-factor-2-family-protein
MDQAYFTAYNECDMATQEKLLSDSLEFYHDQGGLSTSKSGILESIEDNICGQVSRSLVPGSVEVHEIKGFGAVEIGLHKFYNNREPNAISKPSRFVTVWKQENDGWKMHRIISLH
>NC_013222.1|WP_015755346.1|2960009_2960492_+|DUF4870-domain-containing-protein
MTESLSKHERNLSALIHGSTLSRFFIPFGQFLVPLVLWLSNRNQHEFVDYNGKQALNFQISMFLYSFLVGAISIPFFVASIPGLFEHGILSWDDHHNFESFHFDFGTGFFDFPFFWWPVGIGGLLAMGLFVVNIVYTILATIRTNEGQYFRYPLTIKFIR
>NC_013222.1|WP_015755345.1|2959419_2959875_-|DUF4442-domain-containing-protein
MALSVRSFNRFMFFKLPAAWWCGVRLTALDGNRGEAAVTHRWINQNPFRSMFWAVQGMAAELSTGALVMYHIRKSGLPISMLVLNNRANFSKKATGRIRFECPDGDKVRHAIDQAVTTGKGQTVWMQSVGVNADGVTVSTFNFEWTLKVKS
>NC_013222.1|WP_015755344.1|2958970_2959348_-|hypothetical-protein
MPYDLSFQVRPDYVTAELSVKIAPGQELKEAMERWEAIARICRENNRDKVLVVMSFNGSYGMETKFKLAKGASSIGWTPNLKLAVVIPDPDRFSEQLFTETALNNLGYEMKLFLKKRPAKKWLLG
>NC_013222.1|WP_041327258.1|2958037_2958844_-|TIGR00266-family-protein
MNTGNHVVDYEIFGEEMQYVSVELDPNEGVIAEAGSFMMMDPDIRMETIFGDGSKKDTGVLGKIFSAGKRVLTGEGLFMTAFYNGGQGKKKVSFASPYPGKIVPIDLKEKGGRFICQKDAFLCAAKGVSVGIEFSRRLGRGLFGGEGFIMQKLEGDGMAFVHAGGTLARRTLQAGEVLRVDTGCIVGFSQTVDYDIEFVGGIKNTLFGGEGLFFATLRGPGTVYIQSLPFSRLAGRVLAAAPKGGGKDKGEGSILGGLGDLLDGDNRF
>NC_013222.1|WP_015755342.1|2956345_2957932_+|M81-family-metallopeptidase
MNPTRYTLFLLLITLLASCGQNNRSGNEPGTDLPRIAIAGLGIESSTFSPARTEEAAFHPRTGDSVFTRYPFLHTDSVNRKRAEWVPTLVGKALPGGTVTRKAYESLVGQTLKRLEAQKPFDGLFFDIHGAMSVEGMDDPEGDLIYRIREVVGPEVLISTSMDLHGNVSRRLARHTDLITCYRMAPHEDALESKKRAVENLLDRLESGKGKPAYKAWVPVPILLPGEKTSTRVEPGKSLYARVPGVAARDGVVDAAIWIGYAWADEPRNHAVVMVTGDDREQVVSGAEYLAGEFWKVRDEFEFVAPTTDFESALQLALSSEEQPFIISDMGDNPTAGGAGDVTWTLTELLKRREFTTPGGPTLIYASIPGPELIREAVRTGVGGTVSALVGAAVDDRYAPPLLLEGTVTALRKGDQHAGTEAVVKTGNAHVIVTEKRKPYHREEDFTRLGLNPRETDIVVVKIGYLVPELYDMRGGWVMALTPGGVDQDLARLGHQRIIRPMFPLDADMADPDLSARMIPASDNAVPE
>NC_013222.1|WP_015755341.1|2955563_2956172_-|NUDIX-domain-containing-protein
MPENDRLRNIRKETLSSAWYTLYRYDFEYRRSDGRWESRQREVYDRGNGAAVLLYDASRRKVLLTRQFRMPTFVNHNPDGLLTEVCAGLLDGADPEAAIRKEILEETGYRVEQLEKILEAYSSPGAVTEILHYYLAAYHPGQKEAEGGGVPEETEDIELLEFGFEEILEKVRNGEIRDAKTLILIQYAALFGPLRPVAREIQ
>NC_013222.1|WP_187289173.1|2954313_2955570_+|D-alanyl-D-alanine-carboxypeptidase
MGALAILVFLSGCSPVRKVNRHLNNQFQNEAHSNQFTGILLVDATSRDTLFSLNAEKYFTPASNVKLFTLYAALKTLPDRVPALKYARHRDSVYVVGTGDPSALHPDLMDSTALKFIRGFPHVTMVNSNLTDPAWGPGWSWDDFDAYYMPGRSAFPVHGNILRLIGYPDSLHVSPSIFRDSLSPRRGGRARSQLRNVFLRTPSPGDTLDIPLRISGQLERDLWAAFSGRVIVRGDTLPPTPLETLPGMASDSLYAKMMKESDNFIAEQLMLLVSGTQSDTLSFEAARDRVLEEFLPGMPQVPRWVDGSGLSRYNLFTPESVVFLLDKLYREFPEPRLFALLAQGGQDGTLAEWYRDSASPYVFGKTGSLSNNHNLSGYLVTLSGKRVCFSMMNNHFTQPSDVIKENMQELLQWVRENY
>NC_013222.1|WP_015755339.1|2953954_2954152_-|hypothetical-protein
MAGSMLEYTKTVLQKVSFDARLFSRELQKAIKRLLPNELEELRNWLLLFTTDKPELQKTLQYLPV
>NC_013222.1|WP_041327261.1|2963321_2964044_+|DUF2807-domain-containing-protein
MATLARITIGIILALLASSCMLDMNWGAGKRGNGVVVEEARSVTGDFTAVSASEGLDVYVTQGDVYDIRVEADENVIDLIGTDIRDGKLKIHAIENIGRATKNVYVTLPEITALSASSGSDLETRGTIASRNIRLDASSGADLKAAVEADEVEADCSSGADIRVSGRTNLFYADASSGSDIKAGDLQAKICHANASSGADIRVYATESLTADASSGADIHYSGEASVQTKKSASGSVHKY
>NC_013222.1|WP_015755351.1|2964158_2965178_+|dipeptide-epimerase
MKLTLHAHQLELAHTFGISRERYDRQPTLIACLESGGKKGYGEATSNPYYGVTVEGLIKEIEKARSAVEAFPNTDPEAFYELLENLELTPFARCALDLACNDLHGKLLGKPLYAIWGTAARDLPVTNFTIGLDTPEKMVAKMQERPWPVYKIKLGTDRDVALVRELRQHTDAVFRVDANCAWTAGETLDNARALKELGVEFIEQPLPADDWEGMEQVAHGSVLPIIADESCIVESDVDRCGLHFNGINIKLTKCGGLTPARRMIRRGRELGLKIMVGCMTESTVGISAIAQLLPQLDYVDMDGALLLRSDIARGVVITDDAEVILPETGGSGVVLTADL
>NC_013222.1|WP_015755352.1|2965219_2966287_+|pyridoxal-phosphate-dependent-aminotransferase-family-protein
MQNKPQHVAGIPGTEIRLEGATWGYFAGTSYLGLQTLPAFTDLVADATRRLGTHWGASREGPVAPAIYEEAEKQIARWTGSEAACSVSSGFLAGRLLADAFAGTAFQCVYHPACHAALMPAGAERARDLKHMVRQLDEARNNGEAQPVLFTDTIDFSRGPELVFRQLEGIDLSGVILVADDSHGFGVLGPDGAGACSDLASLDAAELIVCGSLGKALGITAGIILGRSERIRQLRRLPAFAGASPAPPAGLAALCTSLESGLIRAQRSKLLLNIRDFQGQLGHLPFLSGLDDFPVYLFAGSGLASFLASQQILVSHFRYSAESSGAPGRIVLTAAHTPVQLERLAKHLSQFPDTQ
>NC_013222.1|WP_041327262.1|2966397_2966838_+|hypothetical-protein
MKKVLGIVFLFAVFLSAVSMSTAPPESLHSLEGTWELQSFCNYADNEPDTISLEEGYRQVKMYYNGKVMWSRTDPSDTIGRFGFGSYKITSNELIEDIEYGDHYFMANLGPMQFRFRLVLDDNSYSQITLDEEGNPTFSENYKRID
>NC_013222.1|WP_015755354.1|2966932_2967910_-|thioredoxin-disulfide-reductase
MSESIERIKTLILGSGPAGYTAAIYAARADLKPVVYTGMEPGGQLTTTTEVENFPGYPDGVDGPTMMVQLQQQAERFGTDVRIGIATAVEFSDEPGGIHRVTIDDDKVVEAETVIISTGASAKYLNIPSEQRLRGGGVSACAVCDGFFYKGQDVAIVGGGDTAAEEASYLAKICNKVTMLVRKDHFRASKAMQNRVMSLENIDIRFNTEVDEVLGDQVVEGLRMVNNQTGEKEEVAITGLFIAIGHKPNTDIFKGQLDMDATGYIVTHGKSTRTNKPGVFASGDVQDKEYRQAVTAAGTGCMAALDAERYLSEVEAGEGEEVEQQ
>NC_013222.1|WP_041327263.1|2968126_2969866_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MKKSYLWIGLALAAGLLLGYFIFSGPGDAMNATGEHNHTQADADQMWTCSMHPQILQPEPGSCPICGMDLIPADSGADGLAPGQLRLTENALALADVQTIRLGDTESGNRVLTLSGTIEANEKKIATQSAYFDGRIETLSINYEGEPVRKGQRLATLYAPDLVAAQQELLTAARLKETQPQLYQAVRKKLELWKLSGERIRQIEESGEVQEYFPVFSDVSGTVSQIDVAAGDYVRKGEPLFRIADLGTVWVEFDAYENQLAALKTGQELTIRAGALEGREFRAPIQFISPILNSTTRTAVVRATIDNSGGELKPGMFVRAELEVSGEAAGEGLVVPQSAVLWTGERSIVYVKPDASRPVFEMREVHLGTALPGGYRVLDGLLPGEVVVVNGTFTLDAAAQLQGKKSMMNPESEPMGKMHDHGDMGSEDGMAANVSSGTGQPGPKLPQADQAVFREVLSAYLELKDALVASDNDKAARAAAHAAGLLKSAGEGLSGLRGDFRELGAATDVDGKRERFIGLSERMVALASGVSDLPGTLFVQFCPMADENRGAYWLSKQESIRNPYFGDAMLTCGEVRDTL
>NC_013222.1|WP_015755356.1|2969862_2970588_-|membrane-protein
MVNRKTARKFRLAHRYLGILLGVQFLMWTISGMYFSWTDLDEIHGDHFRNMEPKQTAFTGLLASDQLGIGEPIATLRLLDIGGEPFYWVNNQSLYHARTGEAKPGISREEALLVAEREMLPGLEVAGVRRIDSVGPHHEYRGRPLPAYEVAYRSPENLKAYVAVANGAFQTVRHRNWRWFDFLWMTHTMDYQTRDNFNTTLLRAFSLFGLITVLSGFTLWFISSPTVRRIQRNLIKKKRTS
>NC_013222.1|WP_015755357.1|2970592_2973100_-|heavy-metal-translocating-P-type-ATPase
MKHTYHIHGMSCTGCQNHVREALESVAGVRGVTVDLDAGVAEVEMDSHIDIGEFREALAGSRYSIHLPGEKPGTAGREASTGTGSNRDSGNGTYYCPMQCEGDKTYDAPGDCPVCGMDLVEQPGSASRQASGYTCPMHPEIRQDTPGSCPICGMELVPVEPEASAEEKVYQRLLRKFWVALGFTLPIFLIAMSEMVPGNPIYNWMDRKYWNWLQMVLSIPVVFYATWMFFTRAYRSVRYWNLNMFTLIGIGAGIAWLFSVFGLLFPGFFPEQFKTDSGEVHVYFEAATVILTLVLLGQVLEARAHRKTNSAVRELLKLAPGKAVRVRDGKEEEIPVEEIEIGDILRVKPGEKIPVDGTLTKGETTVDESMITGEPIPVDKSAGDSLRSGTLNGNRSFLMEAEKIGSDTLLSQIIRLVNEASRSRAPIQNVADRVSAYFVPAVVVIAVITFVVWAIWGPEPAYVYGLVNGIAVLIIACPCALGLATPMSVMVGVGKGAQNGVLIREAAALETLARVDTLIVDKTGTLTEGRPSVEGVEGVPDGVPGEKVLELVASLNQQSEHPLARAMVAHAEQKGVPIQEPEQFESVTGKGVTGMVGKQSLALGNASLMEERGAGIPAVLEEKAREYQDQGKTVSFLSADGEVIGLVALGDRIKDETRTALDQLRQGGMAVHMLTGDNERTARAVAAELGIAEFRAGMLPEDKLSEVERLKRDGKVVAMAGDGINDAPALAKADVGIAMGTGTDVAIESAGVTLVDGDLSGIVKARKLSKKVMRNIRENLFFALVYNTIGVPVAAGVLFPFFGILLSPMIAAAAMSFSSVSVIANALRLRAARIN
>NC_013222.1|WP_041327853.1|2973176_2973713_-|AraC-family-transcriptional-regulator
MVCDRCKSVLADTLEKAGIPLISIRLGELEFPPGYEADFDRIDRILETHGFQRIGEAGAVLVEEVKALLVTALHETLVPLGSLSSFIASRTGRDYSMISKVFSRREGITVEKYWIRLRIEKVKELIQMGQMDFTQIAYALDYSSSSHLARQFKSVTGMSMGSYRKLLDPPRSEWDKIV
>NC_013222.1|WP_015755359.1|2973764_2974322_-|DUF3347-domain-containing-protein
MKRNPFKRLEKTLMPLAVISLMLSCKGEKEANPSPETTGSGTAKTEVKETARIAFEEDATQQVFASYLKLKDALVAGNPDAAKAAAADMGRVPGFENEIVTAEIEAFLSADGIDGQRASFLKLNEKLEPILRDHISEGAVYKQFCPMAFNDEGGFWFSDKEEIRNPYFGDRMLKCGKVEDKLVAL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_013222_3	3.4\|921601\|34\|NC_013222\|CRISPRCasFinder	921601-921634	34	NC_008712	Paenarthrobacter aurescens TC1 plasmid pTC1, complete sequence	131642-131675	7	0.794
NC_013222_3	3.4\|921601\|34\|NC_013222\|CRISPRCasFinder	921601-921634	34	NZ_CP016905	Ralstonia solanacearum strain KACC 10709 plasmid unnamed1	2079101-2079134	10	0.706
NC_013222_3	3.4\|921601\|34\|NC_013222\|CRISPRCasFinder	921601-921634	34	NZ_CP022791	Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence	1007958-1007991	10	0.706

1. spacer 3.4|921601|34|NC_013222|CRISPRCasFinder matches to NC_008712 (Paenarthrobacter aurescens TC1 plasmid pTC1, complete sequence) position: , mismatch: 7, identity: 0.794

--ttaaaggcttccagtccggcaacttcggggcagg	CRISPR spacer
cctcgcagg--tccagtccggcaactccgggggagg	Protospacer
  *.. ***  ***************.***** ***

2. spacer 3.4|921601|34|NC_013222|CRISPRCasFinder matches to NZ_CP016905 (Ralstonia solanacearum strain KACC 10709 plasmid unnamed1) position: , mismatch: 10, identity: 0.706

ttaaaggcttccagtccggcaacttcggggcagg	CRISPR spacer
acaccgccttccaggccggcaccttcggggcgct	Protospacer
 .*  * ******* ****** *********.

3. spacer 3.4|921601|34|NC_013222|CRISPRCasFinder matches to NZ_CP022791 (Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.706

ttaaaggcttccagtccggcaacttcggggcagg	CRISPR spacer
acaccgccttccaggccggcaccttcggggcgct	Protospacer
 .*  * ******* ****** *********.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3116121 : 3123518

Cellulophaga_phage(66.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_049764870.1\|3116121_3116958_-	DNA adenine methylase	Q5QF26	Pseudomonas_virus	9.5e-87	59.6
WP_041327289.1\|3117462_3117819_-	VRR-NUC domain-containing protein	S0A0V1	Cellulophaga_phage	2.2e-24	46.1
WP_015755479.1\|3117821_3119312_-	DEAD/DEAH box helicase	R9ZZ72	Cellulophaga_phage	9.8e-143	52.3
WP_015755480.1\|3119305_3119473_-	hypothetical protein	NA	NA	NA	NA
WP_015755481.1\|3119733_3121998_-	PriCT-2 domain-containing protein	S0A0U7	Cellulophaga_phage	1.4e-209	51.9
WP_083760733.1\|3122016_3122775_-	PD-(D/E)XK nuclease family protein	I3ULL6	Synechococcus_phage	2.9e-10	30.3
WP_148214388.1\|3122840_3123518_-	hypothetical protein	S0A0U1	Cellulophaga_phage	8.6e-46	47.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_013222

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection