CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_013204	Eggerthella lenta DSM 2243, complete sequence	2 crisprs	Cas9_archaeal,csa3,DEDDh,cas2,cas1,cas4,cas7b,cas8c,cas5,cas3,cas9,WYL,PD-DExK,RT,DinG	0	9	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_013204_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013204_1

2311210-2312387

TypeI

Consensus_repeat	Method
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	CRISPRCasFinder
ATTTCAACCCGCACTCCCCATGCGGGGAGTGACN	CRT
ATTTCAACCCGCACTCCCCATGCGGGGAGTGA	PILER-CR

17 spacers

cas2,cas1,cas4,cas7b,cas8c,cas5,cas3

The CRISPR arrays of NC_013204_1

>merge|NC_013204|1|2311210-2312387|CRISPRCasFinder,CRT,PILER-CR
AGTTTCAACCCGCACTCCCATGCGGGGAGTGACCCGCGCGTTCTCGAGCACGGAGTACACCGCGGTGCCATTTCACCCCGCACTCCCCATGCGGGAAGTGATCTACATCCGTTTCAACGAATCGCGTATATTCCTCATTTCAACCCGCACTCCCCATGCGGGAAGTGACCCCGTGAATGCATAGGACGCCATGGCATCGTAGATTTCAACCCGCACTCCCCATGCGGGGAGTAACTGGCCGAGGCCAACGACAAGGCCGTCAACGCCTACCTGATTTCAACCCGCACTCCCCATGCGGGGAGTGACCGCCTACATGGGTTCGCGCCTTTTCCCCGACATATTTCAACCCGCACTCCCCGTGCGGGGAGTGACCAGGTACTCGACGTTCTGGGTGATCGCGGTGGGATTTCAACCCGCACTCCCCATGCGGGGAGTGACGTTTGCAGCCTTGACGCTTTCGTTCACGTCAGTGCCATTTCAACCCGCACTCCCCATGCGGGGAGTGACTAACGGCATCACGGTCGGCACGCCGGTGCAGCTTTTCATTTCAACCCGCACTCCCCATGCGGGGAGTGACTTGAGCCAGCCGAGACCCTGCGAGAGGCTGCCAATTTCAACCCGCACTCCCCATGCGGGGAGTGACGGTTATCAAAATGCGTCTGTTCAAGTTCGTTTAATTTCAACCCGCACTCCCCATGCGGGGAGTGACCAGCTCGACGAACGCGACGAGCGAAAAGAGGCTATTTCAACCCGCACTCCCCATGCGGGGAGTGACTCGTGGGTGCGGTTGTAGCCGTCCAGCACGTCGGCAAATTTCAACCCGCACTCCCCATGCGGGGAGTGACACGGCCTCAGCTCCTCGGTACTGTAAACATAGTAATTTCAACCCGCACTCCCCATGCGGGGAGTGACGCGGCGCTGACTTTTCTTTGGGTCGTCAGCCCATTTCAACCCGCACTCCCCATGCGGGGAGTGACCCATCATGGGCGCTATCGTCGTGGTCGGCATCGATTTCAACCCGCACTCCCCATGCGGGGAGTGACGCCGAGGTGGCTGCCGCGAGGAACGGCGACAACAAATTTCAACCCGCACTCCCCATGCGGGGAGTGACCGGCCACAGGGTATGCATGCATGAGAGCGTATCCATTTCAACCCGCACTCCCCATGCGGGGAGTGAC

>NC_013204|1|1|2311210-2312387|CRISPRCasFinder
AGTTTCAACCCGCACTCCCATGCGGGGAGTGAC	CCGCGCGTTCTCGAGCACGGAGTACACCGCGGTGCC
ATTTCACCCCGCACTCCCCATGCGGGAAGTGAT	CTACATCCGTTTCAACGAATCGCGTATATTCCTC
ATTTCAACCCGCACTCCCCATGCGGGAAGTGAC	CCCGTGAATGCATAGGACGCCATGGCATCGTAG
ATTTCAACCCGCACTCCCCATGCGGGGAGTAAC	TGGCCGAGGCCAACGACAAGGCCGTCAACGCCTACCTG
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	CGCCTACATGGGTTCGCGCCTTTTCCCCGACAT
ATTTCAACCCGCACTCCCCGTGCGGGGAGTGAC	CAGGTACTCGACGTTCTGGGTGATCGCGGTGGG
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	GTTTGCAGCCTTGACGCTTTCGTTCACGTCAGTGCC
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	TAACGGCATCACGGTCGGCACGCCGGTGCAGCTTTTC
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	TTGAGCCAGCCGAGACCCTGCGAGAGGCTGCCA
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	GGTTATCAAAATGCGTCTGTTCAAGTTCGTTTA
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	CAGCTCGACGAACGCGACGAGCGAAAAGAGGCT
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	TCGTGGGTGCGGTTGTAGCCGTCCAGCACGTCGGCAA
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	ACGGCCTCAGCTCCTCGGTACTGTAAACATAGTA
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	GCGGCGCTGACTTTTCTTTGGGTCGTCAGCCC
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	CCATCATGGGCGCTATCGTCGTGGTCGGCATCG
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	GCCGAGGTGGCTGCCGCGAGGAACGGCGACAACAA
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	CGGCCACAGGGTATGCATGCATGAGAGCGTATCC
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC

>NC_013204|1|1|2311211-2312387|CRT
GTTTCAACCCGCACTCCCATGCGGGGAGTGACC	CGCGCGTTCTCGAGCACGGAGTACACCGCGGTGCC
ATTTCACCCCGCACTCCCCATGCGGGAAGTGAT	CTACATCCGTTTCAACGAATCGCGTATATTCCTC
ATTTCAACCCGCACTCCCCATGCGGGAAGTGAC	CCCGTGAATGCATAGGACGCCATGGCATCGTAG
ATTTCAACCCGCACTCCCCATGCGGGGAGTAAC	TGGCCGAGGCCAACGACAAGGCCGTCAACGCCTACCTG
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	CGCCTACATGGGTTCGCGCCTTTTCCCCGACAT
ATTTCAACCCGCACTCCCCGTGCGGGGAGTGAC	CAGGTACTCGACGTTCTGGGTGATCGCGGTGGG
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	GTTTGCAGCCTTGACGCTTTCGTTCACGTCAGTGCC
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	TAACGGCATCACGGTCGGCACGCCGGTGCAGCTTTTC
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	TTGAGCCAGCCGAGACCCTGCGAGAGGCTGCCA
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	GGTTATCAAAATGCGTCTGTTCAAGTTCGTTTA
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	CAGCTCGACGAACGCGACGAGCGAAAAGAGGCT
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	TCGTGGGTGCGGTTGTAGCCGTCCAGCACGTCGGCAA
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	ACGGCCTCAGCTCCTCGGTACTGTAAACATAGTA
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	GCGGCGCTGACTTTTCTTTGGGTCGTCAGCCC
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	CCATCATGGGCGCTATCGTCGTGGTCGGCATCG
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	GCCGAGGTGGCTGCCGCGAGGAACGGCGACAACAA
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC	CGGCCACAGGGTATGCATGCATGAGAGCGTATCC
ATTTCAACCCGCACTCCCCATGCGGGGAGTGAC

>NC_013204|1|1|2311212-2312386|PILER-CR
TTTCAACCCGCACTCCCATGCGGGGAGTGACC	CGCGCGTTCTCGAGCACGGAGTACACCGCGGTGCCAT
TTCACCCCGCACTCCCCATGCGGGAAGTGATC	TACATCCGTTTCAACGAATCGCGTATATTCCTCAT
TTCAACCCGCACTCCCCATGCGGGAAGTGACC	CCGTGAATGCATAGGACGCCATGGCATCGTAGAT
TTCAACCCGCACTCCCCATGCGGGGAGTAACT	GGCCGAGGCCAACGACAAGGCCGTCAACGCCTACCTGAT
TTCAACCCGCACTCCCCATGCGGGGAGTGACC	GCCTACATGGGTTCGCGCCTTTTCCCCGACATAT
TTCAACCCGCACTCCCCGTGCGGGGAGTGACC	AGGTACTCGACGTTCTGGGTGATCGCGGTGGGAT
TTCAACCCGCACTCCCCATGCGGGGAGTGACG	TTTGCAGCCTTGACGCTTTCGTTCACGTCAGTGCCAT
TTCAACCCGCACTCCCCATGCGGGGAGTGACT	AACGGCATCACGGTCGGCACGCCGGTGCAGCTTTTCAT
TTCAACCCGCACTCCCCATGCGGGGAGTGACT	TGAGCCAGCCGAGACCCTGCGAGAGGCTGCCAAT
TTCAACCCGCACTCCCCATGCGGGGAGTGACG	GTTATCAAAATGCGTCTGTTCAAGTTCGTTTAAT
TTCAACCCGCACTCCCCATGCGGGGAGTGACC	AGCTCGACGAACGCGACGAGCGAAAAGAGGCTAT
TTCAACCCGCACTCCCCATGCGGGGAGTGACT	CGTGGGTGCGGTTGTAGCCGTCCAGCACGTCGGCAAAT
TTCAACCCGCACTCCCCATGCGGGGAGTGACA	CGGCCTCAGCTCCTCGGTACTGTAAACATAGTAAT
TTCAACCCGCACTCCCCATGCGGGGAGTGACG	CGGCGCTGACTTTTCTTTGGGTCGTCAGCCCAT
TTCAACCCGCACTCCCCATGCGGGGAGTGACC	CATCATGGGCGCTATCGTCGTGGTCGGCATCGAT
TTCAACCCGCACTCCCCATGCGGGGAGTGACG	CCGAGGTGGCTGCCGCGAGGAACGGCGACAACAAAT
TTCAACCCGCACTCCCCATGCGGGGAGTGACC	GGCCACAGGGTATGCATGCATGAGAGCGTATCCAT
TTCAACCCGCACTCCCCATGCGGGGAGTGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_013204.1\|WP_015760870.1\|2308059_2308425_-\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|198403
NC_013204.1\|WP_174262981.1\|2312543_2312834_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_013204.1\|WP_015760877.1\|2320520_2321105_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239646
NC_013204.1\|WP_015760869.1\|2301634_2301904_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|224937
NC_013204.1\|WP_009304167.1\|2307502_2308063_-\|hypothetical-protein	unknown	unknown	unknown
NC_013204.1\|WP_009304171.1\|2302868_2303336_-\|SsrA-binding-protein-SmpB	unknown	unknown	gnl\|CDD\|376590
NC_013204.1\|WP_015760878.1\|2321101_2322166_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|377367
NC_013204.1\|WP_009304169.1\|2304665_2304947_-\|hypothetical-protein	unknown	unknown	unknown
NC_013204.1\|WP_009304153.1\|2322224_2323418_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NC_013204.1\|WP_015760874.1\|2315440_2317189_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|378245
NC_013204.1\|WP_009304168.1\|2305139_2307506_+\|bifunctional-alpha,alpha-trehalose-phosphate-synthase-(UDP-forming)/trehalose-phosphatase	unknown	unknown	gnl\|CDD\|184712
NC_013204.1\|WP_015760875.1\|2317185_2317848_-\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|187534
NC_013204.1\|WP_009304170.1\|2303344_2304496_-\|M42-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349906
NC_013204.1\|WP_009304164.1\|2309089_2310895_+\|adenine-deaminase	unknown	unknown	gnl\|CDD\|223933
NC_013204.1\|WP_009304165.1\|2308430_2308886_-\|YhcH/YjgK/YiaL-family-protein	unknown	unknown	gnl\|CDD\|377217
NC_013204.1\|WP_015760871.1\|2312844_2313876_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NC_013204.1\|WP_009304172.1\|2301993_2302806_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273344
NC_013204.1\|WP_015760872.1\|2313872_2314535_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_013204.1\|WP_015760876.1\|2318078_2320277_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NC_013204.1\|WP_015760873.1\|2314537_2315437_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458

Protein	Function_ID	Function_description	E-value
NC_013204.1\|WP_015760870.1\|2308059_2308425_-\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|198403	cd10456, GIY-YIG_UPF0213, The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1. This family contains a group of uncharacterized proteins found mainly in bacteria and several in dsDNA viruses. Although their function roles have not been recognized, these proteins show significant sequence similarities with the N-terminal GIY-YIG endonuclease domain of structure-specific endonuclease subunit SLX1, which binds another structure-specific endonuclease subunit SLX4 to form an active heterodimeric SLX1-SLX4 complex. This complex functions as a 5' flap endonuclease in yeast, and has also been identified as a Holliday junction resolvase in human.	4.46029e-34
NC_013204.1\|WP_174262981.1\|2312543_2312834_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	6.31089e-30
NC_013204.1\|WP_015760877.1\|2320520_2321105_+\|NUDIX-hydrolase	gnl\|CDD\|239646	cd03674, Nudix_Hydrolase_1, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, U=I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	7.18898e-40
NC_013204.1\|WP_015760869.1\|2301634_2301904_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|224937	COG2026, RelE, Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning].	1.6336e-22
NC_013204.1\|WP_009304171.1\|2302868_2303336_-\|SsrA-binding-protein-SmpB	gnl\|CDD\|376590	pfam01668, SmpB, SmpB protein.	1.74562e-83
NC_013204.1\|WP_015760878.1\|2321101_2322166_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|377367	pfam04463, DUF523, Protein of unknown function (DUF523). Family of uncharacterized bacterial proteins.	5.47606e-65
NC_013204.1\|WP_009304153.1\|2322224_2323418_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.14604e-16
NC_013204.1\|WP_015760874.1\|2315440_2317189_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	0
NC_013204.1\|WP_009304168.1\|2305139_2307506_+\|bifunctional-alpha,alpha-trehalose-phosphate-synthase-(UDP-forming)/trehalose-phosphatase	gnl\|CDD\|184712	PRK14501, PRK14501, putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional.	0
NC_013204.1\|WP_015760875.1\|2317185_2317848_-\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	1.0955e-97
NC_013204.1\|WP_009304170.1\|2303344_2304496_-\|M42-family-metallopeptidase	gnl\|CDD\|349906	cd05656, M42_Frv, M42 Peptidase, endoglucanases. Peptidase M42 family, Frv (Frv Operon Protein; Endo-1 4-Beta-Glucanase; Cellulase Protein; Endoglucanase; Endo-1 4-Beta-Glucanase Homolog; Glucanase; EC. 3.2.1.4) subfamily. Frv is a co-catalytic metallopeptidase, found in archaea and bacteria, including Pyrococcus horikoshii tetrahedral shaped phTET1 (DAPPh1; FrvX; PhDAP aminopeptidase; PhTET aminopeptidase; deblocking aminopeptidase), phTET2 (DAPPh2) and phTET3 (DAPPh3), Haloarcula marismortui TET (HmTET) as well as Bacillus subtilis YsdC. All of these exhibit aminopeptidase and deblocking activities. The HmTET is a broad substrate aminopeptidase capable of degrading large peptides. PhTET2, which shares 24% identity with HmTET, is a cobalt-activated peptidase and possibly a deblocking aminopeptidase, assembled as a 12-subunit tetrahedral dodecamer, while PhTET1 can be alternatively assembled as a tetrahedral dodecamer or as an octahedral tetracosameric structure. The active site in such a self-compartmentalized complex is located on the inside such that substrate sizes are limited, indicating function as possible peptide scavengers. PhTET2 cleaves polypeptides by a nonprocessive mechanism, preferring N-terminal hydrophobic or uncharged polar amino acids. Streptococcus pneumoniae PepA (SpPepA) also forms dodecamer with tetrahedral architecture, and exhibits selective substrate specificity to acidic amino acids with the preference to glutamic acid, with the substrate binding S1 pocket containing an Arg allows electrostatic interactions with the N-terminal acidic residue in the substrate. The YsdC gene is conserved in a number of thermophiles, archaea and pathogenic bacterial species; the closest structural homolog is Thermotoga maritima FrwX (34% identity), which is annotated as either a cellulase or an endoglucanase, and is possibly involved in polysaccharide biosynthesis or degradation.	3.23421e-129
NC_013204.1\|WP_009304164.1\|2309089_2310895_+\|adenine-deaminase	gnl\|CDD\|223933	COG1001, AdeC, Adenine deaminase [Nucleotide transport and metabolism].	0
NC_013204.1\|WP_009304165.1\|2308430_2308886_-\|YhcH/YjgK/YiaL-family-protein	gnl\|CDD\|377217	pfam04074, DUF386, Domain of unknown function (DUF386). This family consists of conserved hypothetical proteins, typically about 150 amino acids in length, with no known function.	4.78013e-52
NC_013204.1\|WP_015760871.1\|2312844_2313876_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NC_013204.1\|WP_009304172.1\|2301993_2302806_-\|hypothetical-protein	gnl\|CDD\|273344	TIGR00927, retinal_rod, K+-dependent Na+/Ca+ exchanger. [Transport and binding proteins, Cations and iron carrying compounds].	1.01689e-05
NC_013204.1\|WP_015760872.1\|2313872_2314535_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	7.31981e-32
NC_013204.1\|WP_015760876.1\|2318078_2320277_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	3.52204e-58
NC_013204.1\|WP_015760873.1\|2314537_2315437_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.47007e-147

>NC_013204.1|WP_009304164.1|2309089_2310895_+|adenine-deaminase
MINKFCKKPLWECSKTLSAVAQGLAPAETVIKGAKLVNVCTAEIQEDVDVAIAEGRIAYLGRADHCIGEDTQVIDAKGQYIAPGFLDGHIHVESSMMGVGEYARAVVPHGTTGIYMDPHEICNVLGLDGVKVMEEDARRTPLKTMITTPSCVPAVPGFEDTGSSIGPDDVAETMAWPSVVGLGEMMNFPGILGSTDHAHGEVGATLEAGKIVTGHYSMPETDRGLNAYIASGVRCCHESTRPEDVLAKMRLGMYAQLRYGSAWKDLPVLAEAVLANDIDTRFATLVSDDTHPHTLVADGHLDHIVRVAVGLGIDAVTAIQMVTINCAQCFQMDHDLGSIAPGKCADIVFLDDLEDLRVTRVLIDGDVVAEDGRALFDLPPFQFPDWVTHSMHLGRELTPASFEVPAPEGVADGTVRVRAIEIIPAKVGTFEAHVDLPVVDGRLESDLQQDVLKTFVFERHHETGTCGCGFVKGFGIKRGAMASTVAHDAHNLLVVGTNDEDMALAANTLAACGGGMAVVADGEILGLVELPIAGLMDSLDAVTMSEKVHALEGAWAEIGCTMPSPFMTMALIPLACLPELRLTNRGLVDCTTFEFVDLVVE
>NC_013204.1|WP_009304165.1|2308430_2308886_-|YhcH/YjgK/YiaL-family-protein
MLVTTLDHAAGNDYLAARFQKAYAFLNRDDLGSLPLGRVDIDGDAVFANVQEYDTVPAEEKQLEAHRRYYDVQFVVSGEEVMQYAPLEGLAKVQPFDEDADFGLYCTPERPSSIVLRAGDVAVLAPEDAHKPGCALDAPCCVRKIVVKVLV
>NC_013204.1|WP_015760870.1|2308059_2308425_-|GIY-YIG-nuclease-family-protein
MDPRAENDPSFYLYVLECADGTWYTGYTVDVAERVRAHNAGAGAKYTRSRLPVRLLAQAAYATKHEAMSAEYRFKRLMRRQKERLVRRAAREPFEQVLSDLMPAAGVREDTEGVDVGGEAR
>NC_013204.1|WP_009304167.1|2307502_2308063_-|hypothetical-protein
MSLRSAGDDVVSRIARLLELEGDRWRPHRALELLSFVLGDRAQVGDASRYIFAYARHRGYDLPPYPLAGCGEIRAFFADEGVRNVPDWYGKKLGLDERAYEALPSQTVVVLRDRADRRKAFFLDGIRYRNAAAFENLVDSGFSRTLSEDDLEALLSRVLAFLTGDDASVEAETTAVGPLRGSSCAF
>NC_013204.1|WP_009304168.1|2305139_2307506_+|bifunctional-alpha,alpha-trehalose-phosphate-synthase-(UDP-forming)/trehalose-phosphatase
MPNTHSTAATLLRDTPLPLPLARIDRPREESAAARRAQHDARSVVAPEAGRLIIVSNRLPYRFEDDGEGGFELERSVGGLATGLGPLHEQDGNLWIGWADADAGMDDDERARLAAAFDERDCRAVFLDDRDAEAYYEGFSNSAIWPLFHGFPQFTRFDEEEWEAYRRVNERFCEAALAEARPGDTLWIQDYHLMLLPSMLREALPDASIGFFLHIPFPDYETFRTLPWRDEIVRGVLGADLIGFHAYDYVRHFLSSCRRVAGIENTSGTLTVDGRVVQVDAFPLGIDYARFRDAARTPEVQAAVETLAAEKGHEGCKVMLSVERLDYSKGIPERLDAFDAFLDKHPEWKGRVVLMLVTVPSRENVASYRALKKRIDELVGQVNGKHSTMDWTPVDYYYRSLPFEQLVSLYAASDVMLVTPLRDGMNLVCKEYLACHDGDGGVLVLSEMAGASYELHEALCVNPFDRAGIARAMQEALTMPPDEQRKRNAPMQQRLARYTSKKWAREFLDAVADVKRRQAGMSAHLLGPTSAGRLLEAYRRADRRALLLDYDGTLMPFSDDPARVAPDERLLDVLARLGGSADNDVVVVSGRDHATLEAWLGRLPVDLVAEHGVWFAAQADGGTASGRAWTLQEPLDNSWKDAIRPVLADFVDRTPGSLLEEKDYSLVWHYRMCSQELAERRVIEIRCALGDGLADRGIALMDGNKVIEVKPRGVDKGHAAHRWFRDPAYGFLLAAGDDRTDEDVFEAAPDDAWTVKIGGGPTRARFALKNSAEMRQLLEAMAEAEPVR
>NC_013204.1|WP_009304169.1|2304665_2304947_-|hypothetical-protein
MQTYIAHYISPAAADVRGTGLFEFESDSRANTKGNLRDARLKMLELYGKDAVSWTIDSVERKKASVASQDGQLALDFRPPKPERKRAKKKEYW
>NC_013204.1|WP_009304170.1|2303344_2304496_-|M42-family-metallopeptidase
MKNKQVKFLKQLLETPSATGTEIAVAELVRERLAGTADEIQTDVMGSVHARLSGTGVAPSLMLSAHMDEIGLMVTYISDEGFLSVSSVGGVDAAILPGMRVDVHASNSFEPLRGVVGRKPIHLIEPDERKNVTPIDKLVIDLGMPAKRVKKLVMVGDVITFGVGFERFGKNMAVSRAFDDKAGVWVAVRVLETLAKEGRAPGDFIVAATVQEEIGTRGAITSAYGLDPDVAIAFDVTHATDYPGIDKTKYGKIVCGEGPVIARGPNINPAVFERLVAAAEAEGLPYQIEAEPGVTGTDARSIQISRGGVPTGLVSVPLRYMHTPTEVVSLDDLDATVKLLARFARDLDEDACFVPGMGDAVTEGDGAGAESAAQMQFDETGVE
>NC_013204.1|WP_009304171.1|2302868_2303336_-|SsrA-binding-protein-SmpB
MKREEKTIAKNKKAFHEYEILETLEAGIELTGTEVRSLRDNHCQLTDCFALIRDGEVWLHNVHIPPYLNGNIANPDPDRKRKLLLHKKQIRQLQEQVKEKGMALVPVKMYFKDNSLVKVELAVARGKKLYDKRATMAARDSRREVERALKERSRY
>NC_013204.1|WP_009304172.1|2301993_2302806_-|hypothetical-protein
MGLDEELETIEDGAETEAEQIDQETELEDVEEFQNDEEFDPSDDETDLEEAYEGFFAEEGPDGEGETSLDGEDGGLAAVASQAAGIDLSEEGFHIVDGDEADEEAQLYENGSLDSYDADALNEDGDATAGSVPEVDEANALEELEDGQDDDVQDVVIIEPSAEDDGYELVELELDDDDIVRYIEDEDGDVIGFVLMEDGEEAEYYYVEEDEEEAEEEDNPYDLGITKEGVAEATNDMNAIYKDGIAVAAELKGAFDDIKSALDFTSFLKK
>NC_013204.1|WP_015760869.1|2301634_2301904_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MSWALAYSERARRQLRKMDPGQRAIVLSWMDKNIDGCDDPRAHGKGLTANRSGQWRYRIGDYRVLCDIVDEKLTVLAIEIGHRSKIYER
>NC_013204.1|WP_174262981.1|2312543_2312834_-|CRISPR-associated-endonuclease-Cas2
MLTVITYDVNTEDPAGRRRLRKVARHCVNYGQRVQNSVFECVADAATMVRIKSELVELIDPEKDSLRFYSLGSKYETKIEHVGAKPTYEAEGFLAL
>NC_013204.1|WP_015760871.1|2312844_2313876_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MRHLLNTLYVFTEDAYLMLDGENVVVRRDGAELGRVPLHTLEGILCFSYRGASPALMGACVERGVGLSFFDRKGRFLAGAYGEQRGNVLLRKTQYAWSEETEKSLAIARNFIVGKLYNGRWVLERAVRDHGLRIDTGSVKAASMRLDGSLRSAAECETMDSLRGIEGDAAAEYFGVFDELVLRDKETFRFTGRARRPPTDAMNAMLSLFYTVLAFDCASALEGVGLDPFVGFMHADRPGRRSLALDLMEELRPVFVDRFVLSALNNRVVSSKDFEKRESGEVRLGDEGRRALFGAWQERKKETITHPFLKEKIPRGLVPHVQALLLARCLRGDLDGYPPFLWK
>NC_013204.1|WP_015760872.1|2313872_2314535_-|CRISPR-associated-protein-Cas4
MYDEDEFLALSGIQHFAFCRRQWALIHIEQAWADNVLTAQGELMHKRAHDEELRERRGDTLVVRGLSVHSRALGLSGKCDVVEFRKNSHGHTLTGEDGLWRAVPVEYKRGSSKANDADRLQLCAQALCLEEMLGADVPIGFLYYGETRSREKVEFDESLCALVGSMVEEMHALYRRRHTPRVKPFSACRSCSLNDLCLPRAINRATVGEYVAKRLFEEEL
>NC_013204.1|WP_015760873.1|2314537_2315437_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSDTIKNRYDFVVYFDVENGNPNGDPDAGNMPRIDPETSLGIVTDVCLKRKIRNYVETVKEGERGFEIYIKDGVPLNASDRRALDEFGVGTDDKAIKKLKKDDPALDEKIRDFMCETFYDVRTFGAVMTTFVKGALNCGQVRGPVQLTFARSVDPIIPQEVTITRVAITTEADAEKKGTEMGRKYVVPYALYRGEGYVSANLARKSTGFSEDDLALLWDAIVNMFEHDHSAARGKMAVRALVVFKHDSELGNAPSYKLFDAVSTQKKAGVEAPRSIDDYEEITVDEGAVPEGVTVLRMV
>NC_013204.1|WP_015760874.1|2315440_2317189_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MILQALADYYEQLSREHPERIARPGWCSRQVAFMLELSPDGELVNVIPAEEKRGWTREVPEQAKRTVGVTANLLCDNATYLLGLDAKGKPERARRCFDDARRKHLELLADVDSPVATAIRSYFETWNVEEASEHPRVVDAGEGLLAGGNLVFFVQGCEALADRDICAAWDRRCERSGKDEEVTTCLVTGEKAPIARLHPAIKGVMGAQSMGASLVGFNARAFESYGHDEEQGLNAPVSERVTFAYTTALNYLLSDRNHHIRLGDTTIVYWADSDDEDCAALFSQAINPNFGERAEGEDDPDEKLDAIMGALAAGRQVESAKLDATFHVLGLAPNAARLSVRFFMSGMFGSMLDNLRKHYDRIDITRAPYEKKYLSPYFLLAETANPNAKQAAATSVLAGALMRSILADAPYPEALYSNVLLRVRATQDDDDRRTRKVTRGRVAIIKAYLIKNLNKEAVTVSLDETKRDTPYMLGRLFSVLERVQEEANPGIKTTIKNRYFDSANAMPSVVFPVIMKLGQNHLNKIAGDRKGLAVFYEKQIQELCNGIQGFPKRLSLSEQGGFILGYYHQTQKRYEKKNDQEG
>NC_013204.1|WP_015760875.1|2317185_2317848_-|type-I-C-CRISPR-associated-protein-Cas5
MAYGIQIEVWGERALFTRPELSVERVSYDVITPSAARGLIESIYWHPGMRYTIDRIHVLNPIRFTNVRRNEVKSKALASSIRSVMTHGGELPYINTKEDIQQRASLILTDVRYVIEAHFELTDRAKPEDNPGKFKDIIRRRLDRGQCYSTPYFGTREFAAHFKACDGDAPQGCYADSGERDLGLMLYDMDYVDPQNIMPMFFRAVMRNGVIDVAGSEVFR
>NC_013204.1|WP_015760876.1|2318078_2320277_-|CRISPR-associated-helicase/endonuclease-Cas3
MHVSHVAEDGRIEEVADHLREVAEMAAEFARPFGAESWAYAAGMAHDIGKYSTEFQNRILCDGHKVDHSTAGAALLDQLGLKLLAYCVAGHHAGLPDGGTTADVEDCPTLRGRLLRAQHGSIPDCAAYAREVELNVPKGPSVLPVSRDREDGAYSLSFLTRMVFSCLVDADFLCTERFMQGEGRDPLSEQSLVDLLGCLKEEVARFYPPTSALNETRCQVLDACIRAASNHPGFFSLTVPTGGGKTYASLLFALEHAVKRDARRVVYAVPYTSIIEQNARVFRDVLGERSVLEHHANFDFDFDEEVESYKSGDAKKALRRASENWDAPIVVTTNVQFFESLYANRTSRCRKLHNIANSVIVLDEAQMVPTKQLLPCLRALIELVANYGCSVVLCTATQPAFNGMLGRKGFAVREIAPAPSELFKKLKRVSYRFDGVLGDDDLAARLADRDQSLCIVNSRKQARRLHELLDGEDSYHLTTLMHPVHRERVLNEIRQRLREGRTCRVVATSLIEAGVDVDFPVVYRALAGVDSMVQAAGRCNREGRQSAEESIVHVFEPADDYALPSDVAQKVAIARSVISEMEGAACESCDIGALEAIDAYFARLYAVREGALDASGVLRDLEGFSLKSLNIPFKRAADDFRMIEEGSRTVVIPDPEIESDILAVKTGFANRSTIRRLSRYAVGVYDGDIKALLRSGKIETLAEDLFVLVDGTCYSDQRGLDLKNEEGKGIFL
>NC_013204.1|WP_015760877.1|2320520_2321105_+|NUDIX-hydrolase
MSLATDIRSYQPFNQQEASDREVILRQLETDPHVFDRDSLAHMTCSIWTVDPTVTQTLTVFHNTYGSWSWIGGHADGERDLERVALRELEEETGVADARIVPCGPGNIFSLEVLTVDGHEKRGRYVSSHVHLNVTYLAVASPDDPLRVKPDENSGVRWMDFDEALAASTEPWMRDRIYRKLVDKLAAVDLEMRR
>NC_013204.1|WP_015760878.1|2321101_2322166_-|GNAT-family-N-acetyltransferase
MPIAVSACLLGEPCRYDGKSRPCEDVLKLHDACEMVPVCPEVLGGLPVPHAPCEIAAAERALRVTDADGVDVTDAFLAGAAKTVELAQEQGCKLAVLKAKSPSCGCGLVYDGAFAGELVPGYGVAARALREAGVRVLDEVRFAACVRAGEARHPGCPPAILAVTSGECPALETERLVLRPFVSDDIDDVYAYCSDPAVGPDAGWAPHRTREDSRMFVEVIASEPHVFGIFEKTGAGTGATGPCIGSIGLIRDPQRRNVDCLMLGYALARTAWGRGCMTEAADEMLRYGFEELGLGLITCTHYTFNDRSRRVIEKAGFVHEGTIHGAEATPDGLMQDFESYYLPRELWDEAKGRG
>NC_013204.1|WP_009304153.1|2322224_2323418_-|MFS-transporter
MLAHAVDASESSQPRQGVRGLVIATFAFVTVFAASAVPIPLYSEYKGAIGLTDADISATMLMYLFGVVLTLFLSGSLSDAAGRRPLAAASLLLAMLGCFLFLRAADPTIVLVARAVQGVSCGLAMSAVSALVVDSAVGRYEGFGLAVAGCGALLGVMAGSLAVGFLSLVTQQHALIYWIMIALLALGAILIPAAPETVVSRVPLRTACKPVIGVDAKLRGVLPIAACAYVASWGVGTFFQSFSSPVAAECFGSSDPFMASAILALSMAPSALGAPLEARMPSGVSLRVSMAALLVFTCAMCVAMAAGALGAFLVLVALFGLSTGMCLSGSLRLLFARADMRSTATVVSTINLIGYTGSAVLSGMMGALVGATTLVGVLAALAMFAAVATVLVFARTR

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Crispr_ID: NC_013204_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013204_2

2773356-2773443

Orphan

Consensus_repeat	Method
CACCGTCACCACTAGTGCGAACACCTAGATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013204_2

>merge|NC_013204|2|2773356-2773443|CRISPRCasFinder
CACCGTCACCACTAGTGCGAACACCTAGATCGAGTGTCGGGACGCTTTCCCCGAAGCCACCTTCACCACTAGTGCGAACACCTAGATC

>NC_013204|2|2|2773356-2773443|CRISPRCasFinder
CACCGTCACCACTAGTGCGAACACCTAGATC	GAGTGTCGGGACGCTTTCCCCGAAGC
CACCTTCACCACTAGTGCGAACACCTAGATC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013204.1\|WP_035586457.1\|2781806_2782919_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|379138
NC_013204.1\|WP_015761118.1\|2783109_2783670_-\|hypothetical-protein	unknown	unknown	unknown
NC_013204.1\|WP_009305046.1\|2761721_2762045_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|368240
NC_013204.1\|WP_015761114.1\|2776507_2778946_-\|phenylalanine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234804
NC_013204.1\|WP_009305052.1\|2766924_2767734_-\|hypothetical-protein	unknown	unknown	unknown
NC_013204.1\|WP_009305057.1\|2773566_2774451_-\|methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
NC_013204.1\|WP_009305049.1\|2764466_2765750_+\|glutamate--cysteine-ligase	unknown	unknown	gnl\|CDD\|226102
NC_013204.1\|WP_009305060.1\|2776058_2776361_-\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143393
NC_013204.1\|WP_009305059.1\|2775721_2776072_-\|DUF86-domain-containing-protein	unknown	unknown	gnl\|CDD\|225236
NC_013204.1\|WP_009305051.1\|2766386_2766815_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223976
NC_013204.1\|WP_015761119.1\|2783666_2783858_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224393
NC_013204.1\|WP_009305050.1\|2765746_2766181_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|223976
NC_013204.1\|WP_009305062.1\|2779136_2780198_-\|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|234780
NC_013204.1\|WP_015761113.1\|2767720_2767966_-\|hypothetical-protein	unknown	unknown	unknown
NC_013204.1\|WP_009305058.1\|2774696_2775422_-\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NC_013204.1\|WP_009608760.1\|2770003_2771659_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|273816
NC_013204.1\|WP_009305047.1\|2762019_2762295_-\|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	unknown	unknown	gnl\|CDD\|376852
NC_013204.1\|WP_009305048.1\|2762478_2764329_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224011
NC_013204.1\|WP_015761116.1\|2780634_2781810_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226400
NC_013204.1\|WP_009305054.1\|2768158_2769709_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715

Protein	Function_ID	Function_description	E-value
NC_013204.1\|WP_035586457.1\|2781806_2782919_-\|serine-hydrolase	gnl\|CDD\|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	7.22147e-31
NC_013204.1\|WP_009305059.1\|2775721_2776072_-\|DUF86-domain-containing-protein	gnl\|CDD\|225236	COG2361, COG2361, Uncharacterized conserved protein [Function unknown].	1.32892e-13
NC_013204.1\|WP_015761114.1\|2776507_2778946_-\|phenylalanine--tRNA-ligase-subunit-beta	gnl\|CDD\|234804	PRK00629, pheT, phenylalanyl-tRNA synthetase subunit beta; Reviewed.	0
NC_013204.1\|WP_009305057.1\|2773566_2774451_-\|methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	4.08834e-121
NC_013204.1\|WP_009305049.1\|2764466_2765750_+\|glutamate--cysteine-ligase	gnl\|CDD\|226102	COG3572, GshA, Gamma-glutamylcysteine synthetase [Coenzyme metabolism].	2.63828e-57
NC_013204.1\|WP_009305060.1\|2776058_2776361_-\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	3.62294e-16
NC_013204.1\|WP_009305051.1\|2766386_2766815_+\|peptidylprolyl-isomerase	gnl\|CDD\|223976	COG1047, SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones].	3.9511e-39
NC_013204.1\|WP_015761119.1\|2783666_2783858_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	1.39126e-24
NC_013204.1\|WP_009305050.1\|2765746_2766181_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|223976	COG1047, SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones].	1.48695e-20
NC_013204.1\|WP_009305062.1\|2779136_2780198_-\|phenylalanine--tRNA-ligase-subunit-alpha	gnl\|CDD\|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0
NC_013204.1\|WP_009305058.1\|2774696_2775422_-\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	3.0806e-17
NC_013204.1\|WP_009305046.1\|2761721_2762045_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|368240	pfam05016, ParE_toxin, ParE toxin of type II toxin-antitoxin system, parDE. ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.	6.46316e-05
NC_013204.1\|WP_009608760.1\|2770003_2771659_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|273816	TIGR01813, Fumarate_reductase_flavoprotein_subunit, flavocytochrome c. This model describes a family of redox proteins related to the succinate dehydrogenases and fumarate reductases of E. coli, mitochondria, and other well-characterized systems. A member of this family from Shewanella frigidimarina NCIMB400 is characterized as a water-soluble periplasmic protein with four heme groups, a non-covalently bound FAD, and essentially unidirectional fumarate reductase activity. At least seven distinct members of this family are found in Shewanella oneidensis, a species able to use a wide variety of pathways for respiraton. [Energy metabolism, Electron transport].	6.60411e-40
NC_013204.1\|WP_009305047.1\|2762019_2762295_-\|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	gnl\|CDD\|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	3.31719e-06
NC_013204.1\|WP_009305048.1\|2762478_2764329_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224011	COG1086, COG1086, Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	0
NC_013204.1\|WP_015761116.1\|2780634_2781810_-\|hypothetical-protein	gnl\|CDD\|226400	COG3883, COG3883, Uncharacterized protein conserved in bacteria [Function unknown].	9.30324e-16
NC_013204.1\|WP_009305054.1\|2768158_2769709_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	2.69283e-14

>NC_013204.1|WP_009608760.1|2770003_2771659_+|FAD-dependent-oxidoreductase
MHEHNNGISRRDLFKFGGIAAAGVVGAGALASCAPQGTGSAGSASTTSTTDETTTAAGHLRTGMPSFLTAPEAITDVKETKDYDVVVIGAGASGVPAALSAFEAGAKVALLQKESQAIAQGNSGSGIDLATSNPADIANLVSQLIADSQHRPNRELVELWAQNSGEAVKWVIEKSLEGGAQVIDQGNQQHMPLINKKGYDINFVTSFFGPKPYNTGDGMRALAATAEKEGVEIFYSTPAEQLVTGDGGKVTGVIAKGKDGHVQFNASKGVIVACGDYQNDEEMLHYYQPDMTNFEPKQTNKTGDGHKMVVWAGGKIEDLAHTKMLHDFDAGPASMCDMPFLAVKMDGTRFVNETVEMSLLNCYLRSKEDSGHYCQVFDSNYMEAAAEWPGKLVDPEGLKVYMPEEDVEREGVFEGQINTFKADTLEELADKLEIADKAAFVASVKRYNELAAAGKDEDFGKPANYLVPVDTPPFYGIHRHVRMSAICSGVDVNAKHECLTPEGEVIENLYAIGNCSGHFYGGIDYPLTVFGLSLGRCYTEGYVIGRMVAEK
>NC_013204.1|WP_009305054.1|2768158_2769709_-|helix-turn-helix-transcriptional-regulator
MENGETKGSGEFDRPRESAELRFADDEAVGVREADAPACEDGTVAGARAPGPLLPWLPSIPLFFLGLGVYRAWIEIVFVGSFVEFPAAAVAGHDAFDLVMIATMFLCAALAKRIGPLFGKRSLYAVSGVALTVSTLCMFASIWIPRSADALAVPAVLLGGFGIALVILLWSELYGCLNPFRVALYYSASMIVAALLIYLCRGLLLPWLGAVVLVLPVVSLAACAAGFRSLPSGELPRAKPSKFSFPWKIVLLMAIYAFAYGLKESSMYQSTFGPHSAFGTLAVAAIVFVGVIARGGKFDFGVIYRIALPLMVAAFLILPNVGVLGQAASDFCTSASYTAFSILIMLIMANLCYRYGMSAVWLFGIERGVRALFTLFGRQTEQLLGAPSFGLAGSDAVVSGLVVILVVAATMILFSEKELSSRWGVSFLGEDGAAGDRAIVKKQELANRCQELARSYGLSPREEEVLLLLAQRKTVGSIERELFIANGTAKTHIRHIYRKLDIHSRDELSDLLGLFE
>NC_013204.1|WP_015761113.1|2767720_2767966_-|hypothetical-protein
MPAFGNQTSCSYPETLVLVEALPLCRILASDWPGEEVPAEFPLFDEEVEAESMLARPLRCAAVMPCAEAFALLEEVGHVGW
>NC_013204.1|WP_009305052.1|2766924_2767734_-|hypothetical-protein
MSDGSAWEREALSIKQVPSLQALLRCCDERLLVRAIVEEHAVLAGDWDALPAKRKRAAEKRLAATLATMRGLPLDKKGARGSLLLPHESFVLHARSGLIERHVSAALLSLDDVPLARRAVQRSDAAPPGEAEGPQPRPYTLDPWERTLASRVWLGGSRCCRERYLVLAAAFWEMTYFGFEYERVCARRAEEKARRLVGKDVPGERPSEPPRTVSDERRRQAEGFGLVEPDRFELDYRDSMIVRVAQLNDDSRKALWLLLLDVARRLGKA
>NC_013204.1|WP_009305051.1|2766386_2766815_+|peptidylprolyl-isomerase
MSNEGKKVKVHYTGTLDDGSKFDSSVDRGEPIEFTCMAGQMIPGFDSAVKDMAQGDTKNVHIPAAEAYGERDEAMVQQVPVDQIPNGDQLPVGQTVYMMGPGGQPFPVFVRSIEDGIATFDMNHELAGKDLNFEITLVEVAD
>NC_013204.1|WP_009305050.1|2765746_2766181_+|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MSNEDRMVKVAYRGYFDDGATFIDQTRQPIEFPCADGWMPPAFVDAVRDMAVGETKRVRVGADEAYEKRTEERVIEVERAKIPANIKLAVGDVMSLERPDGQTYPARLVELDEERAVFDLNHDAIAKALNFEITLLDVRDLPKR
>NC_013204.1|WP_009305049.1|2764466_2765750_+|glutamate--cysteine-ligase
MNKTAATGQEQPARESNINAIVSYFESGIKAFGGPGELGIELEQIIVHDDLSPVSYSGEHGVAWVLRQLAADYPRTTTDEHGDLLGVARPSEAVTIEPAAQIELSAGPFADLATARDTFEGFAQRLSDVLEPAGEKALAIGYHPSATARSLELIPKRRYQFMDLYLGERDIYGPCMMRGSASTQVSIDYTSTADCLRKLRLAFALVPMLSLMCDNAPVFEGKPREHQLVRTDIWQHVDNDRCGLVPDVLDPSFDLRRYAEYILDTVAILIPCQQQRWCYSDRTFGDIYAARTMTRAEVEHAVSMFFTDVRLKTYIEIRPADAMPIPYVIAYAALIKGLFYAPTSLDAMDGLFADVRRDDYLAAQDALMERGYEAEVYGRPVAELCDRIVKIARDGLADEEQGFLEPLADLVARRVTLADLAERSERA
>NC_013204.1|WP_009305048.1|2762478_2764329_-|polysaccharide-biosynthesis-protein
MDAHITKRTAILLLLDIVATYAAYWLASLLTDVEGEVFVNNEIYFMLGILALINVAVLGLFHLYNNLWEYASVDEAIQIVLAVVLSTLVGAVFLWIIDVRLPIRVFFVSCFMLIFFMGGIRLIFRVMRQKRRALVSTQRACDRPRTLVVGAGETGSLAIGRMASKDPLMPGIPIVATDDDPTKRGSRIHGVRVAGSTDDIVDLVDKHNIDQIVVAIPSSTPEERKRIYGECTKTDCKLRTLPNVRELSLDEIGDVRLRDVDVADLLGREEIILNTRAVSGYIAGETVLVTGGGGSIGSELCRQLCKVAPARIVIFDMYENDAYMLRNELLAEYDDIDLVIEIGNVCDEARLNEVFAKYRPGAVFHAAAHKHVPLMEQCPREALHNNVFGTLNAVRAADAYGAARFIFISTDKAVNPTSVMGATKRMGEMVMQYYARTSKTIFSAVRFGNVLGSNGSVIPVFQRQIAAGGPLTVTHPDIERFFMTIPEASRLVIQAGGMAKGGEIFILDMGEPVKIVDLAKGLIQLQGLTPDVDVKIVFTGLREGEKMYEELLMDEESTLPTDNHSILISTGQEISYTEVAEKLDELEAALTLTDEEAVHVLEKTVCTYRHTPNKVS
>NC_013204.1|WP_009305047.1|2762019_2762295_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin
MNIRPISDLRNRYADVERDVIEGGPVFLTKNGYGSMVVMSVEQFEHINGGVEFALDAADRQAATTSLRYTHEEVFGSIREGLRNGREAAAL
>NC_013204.1|WP_009305046.1|2761721_2762045_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MDEKPRRYRLEYLPLFWDDLNEAVSYIADVLKAPEAAERLIDATEAGILAHSRNPTLATTYKTAKPRPLPYYWFEVGNYMVFYVVLDDVMEVRRFLYGARDLTKMLP
>NC_013204.1|WP_009305057.1|2773566_2774451_-|methionyl-aminopeptidase
MYDGRTNPGRNDECWCGSGKKYKKCHLAFDERLQSMYEQGFELPDRASLKSAADIEGIKRSATINIGVLDYVAERIGPGTTTEEVDRWVHDYTVEHGGIPADLNYEGYPKSVCTSINDVVCHGIPSEDDVLREGDIVNVDCSTILDGYYSDSSRMFRIGEVSPERARLVDETKKAMEAGLAAIEPWGLLGDVGAAVNAYAKAQGFSVVREFGGHGIGFDFHEDPFVSHVSEPGTGMVLVPGLVFTIEPMVNAGEAPIDMSDPNGWTVRTADGSDTAQWEVQVAITEDGHELLSW
>NC_013204.1|WP_009305058.1|2774696_2775422_-|TVP38/TMEM64-family-protein
MAKSVGTQDRELRKRRMAVAAALLAFAGIVGVLALLFGRDALAFLTDGHRVQQQVERLGPLAPVVFGLLVVLQEVTVIVPSEPLELAAGYAFGFWEGAFVYLAASVVGCFAIIAVVRFGGDRVLELVLTRKGREWLARLRGAQRFDFAILAAFFIPGLPKDLMAYLAAFAGMHPVHLAVVTTAGRLPSVLAITLGSSFAAAGDWRATAIVFSVTAAAVVIGALAYHRFKRQRDGGAGGAAK
>NC_013204.1|WP_009305059.1|2775721_2776072_-|DUF86-domain-containing-protein
MRNPEAIECIELMVPLCDIVSDRIARYSMSRESVCLNDDHLDLLLMPIFQIGELIGGGGYLDALQELYPSDMWVQAYGMRNRIAHGYAKLKPAIVWETAITSIPALRELCLRLLED
>NC_013204.1|WP_009305060.1|2776058_2776361_-|nucleotidyltransferase-domain-containing-protein
MKVLDQHTIASAVRSIAPGYGVVKAYLFGSHARGDADAASDVDLCIEPDDGFTLFSLGGFGSHLEEALGVPVDVVCGDDSFYPRARERYERDRKLIYEKS
>NC_013204.1|WP_015761114.1|2776507_2778946_-|phenylalanine--tRNA-ligase-subunit-beta
MKVSLKWLSEYVDVPSDVKAFCDRLDLTGTGVEAVEKTGDAFDGVVVGYVETCEQHPDSDHMHVVTVDVGAGEPVQIVCGAPNIAQGIKVPVATIGAVLPGDFKIKKSKLRGITSCGMCCSQRELGMGSNHEGIWILPEDAPVGMPIADYLKLSDTVLDLEVTPNRPDCLSMAGMAREVGAMYRTDVKRPQIDLVEDADATPASDQVSVEIADASRCCRYTARVIKGVQVGPSPDWLAERVAAAGARSINNIVDVTNYILFLLGQPLHAFDFDKLAGADGKAHIVVRPAAEGERFTTLDGEDRQLVPDMTVIATPERAVALAGVMGGLETEVTEATTTVLLEAAAFDRAHTSRTSRNLGLISESSMRYERGVDDNPVALNADMAAALIAEVSGGSVCPGMVDVWLEKTDPIDLEFRVPRFCAMMGAEIPREEVVDILSRLGCEVSDADDADVLSVTAPTFRPDLEREIDLYEEVVRLWGMDRIPATLPGGRGRYGTRSQLEHVSDIIHRTMCASGLNETMTYSFAEPGDLDRLRMSHEGLGRPVELINPLNADQSVMRQSIVPGLMRSVAYNQSRGVKNVQLYEMGAVFFAHEGKSQPKERRRLAGVMAGAMGDAGWNSAPAAFDFFDGKGAIENLARELALPKLRFKALSADEAPHLQPGRAAAVLSGGTELGWVGELHPLAVDAFDATAPVVAFELDVDALAKSARPARDYVDVPTFPAVSMDVAFVVDEGVTHERLVQCMTSAGGKLLEDVRLFDVYRDEARVGAGKKSMAYALTYRAADRTLTSEEVDKAHERLVKKVSSATGAEVRG
>NC_013204.1|WP_009305062.1|2779136_2780198_-|phenylalanine--tRNA-ligase-subunit-alpha
MAIVEELEALREQTIAQIAQAADTAALEQVRIGVLGKAGTLTGYLRQMGQIAKEERAAVGKTANEVRAAVEGALAARKEELAASELAAAIDAAAVDVTLPGRSQQVGTRHLINRITDEISEIFLGLGYTVATGPEVETDYYNFEALNAPADHPSRSLADTFYVRDLSGAQAAVRGESDVLLRTQTSGVQVHAMEDNELPIYVIAPGKVYRRDVADPSHLPQFTQIEGLVVDEGITFGDLKGTLDYLCKQMFGEERKTRFRAHYFPFTEPSAEVDVSCGICHGEGCRFCKGTGWLEILGCGMVDPNVLSMSGIDPEKYSGFAFGMGVERIACLKYNVPDLRMLVEGDMRFLRQF
>NC_013204.1|WP_015761116.1|2780634_2781810_-|hypothetical-protein
MRSARWSVPNAMLAGVLALALCSGGTVFGGGVFSRAWADEAEEAQRAVDDAQATLDDAEAHMESIAGDYDALKQDVEELQARVDEISAQAMDAQQAVIEGRAALGKTAVHEYLNGGASQSLVTMVLEARSFSDLIRNLTYLDSIMQFHADEVEAQKERSAKYEKLIDDLNFQKDEQEKKLEELEAKRAEAETVLSQASSKLSNAQSDQAARLEALRQKAEELAAADGATGPVIDENADTIGREDVVDSNTPVQPNPDPNPPAPAPEPSPDPDPAPSPAPDPGISWSTGIASAYGGSTDPYTPNPGTTANGSVCDDNSMGVAIPMSWPNFRSYFGRTVEISYNGQTVLATVNDCGGMGGGSRSLDLQPGVWKAFGFSSCLDWGLRTVNYRFL
>NC_013204.1|WP_035586457.1|2781806_2782919_-|serine-hydrolase
MKHRPALVAGVIVGAVAVLAIGACAMAASAVRPEDPVAVADEVVAALPEATAQTGQAAASQAQSGDVVDPRAVAEDARTALDAASGTEDVNLFNSVTGIARTLSSDEISDVEGAIAAYHDAGYEVGFVMYDLTTHEGVGYNADQWFFSASTVKAPFVAFASQDMVDGGRASLDEEVVEDVILDGTGIMSSDDIDRYDLQTVMANTIVHSDNTGYGLLRERFDQNDFQAWCAAADVDAAAWQGEWYPYYTPRDLAKMWLNVGAYVAEGQGNAPWLADVLQQTELSFLRTALGEGRRVLSKPGYEIDTPWYDMGALNDAGLVVTDTDVYVIAIMSDADYDDEYFTDNEHLIVDLASALGAAHDRLLFEGGVA
>NC_013204.1|WP_015761118.1|2783109_2783670_-|hypothetical-protein
MKIIERWREHRGSVDERVEAESNRVYKLGFVMLSFGVLVYLYYDWSLKQAMCMRDVLANGAGRMEFTSADLFLYGWFALTMIVGMVLLVRKGFGDDNRFAEAEQFPIGYYAIASIAFAVAVDVLTTGLRVLAEFQVLGAGEIMWPAVAFGSVFALVAGIPLFLLGFWVAFKSAQSRRRQLDMRLGE
>NC_013204.1|WP_015761119.1|2783666_2783858_-|helix-turn-helix-transcriptional-regulator
MKAARVAADLSQADLAAAVGATRQTIGLIEAGGYNPTLKLCIAICKTLGCTLDDLFWEEGSAT

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_013204_1	1.10\|2311853\|33\|NC_013204\|CRISPRCasFinder,CRT	2311853-2311885	33	MG592415	Vibrio phage 1.031.O._10N.261.46.F8, partial genome	64436-64468	6	0.818
NC_013204_1	1.24\|2311583\|34\|NC_013204\|PILER-CR	2311583-2311616	34	NZ_AP017976	Microbacterium sp. TPU 3598 plasmid MST3P, complete sequence	5747-5780	7	0.794
NC_013204_1	1.28\|2311854\|34\|NC_013204\|PILER-CR	2311854-2311887	34	MG592415	Vibrio phage 1.031.O._10N.261.46.F8, partial genome	64436-64469	7	0.794
NC_013204_1	1.2\|2311312\|34\|NC_013204\|CRISPRCasFinder,CRT	2311312-2311345	34	NZ_CP021745	Agarilytica rhodophyticola strain 017 plasmid pSU1, complete sequence	45283-45316	8	0.765
NC_013204_1	1.6\|2311582\|33\|NC_013204\|CRISPRCasFinder,CRT	2311582-2311614	33	NZ_AP017976	Microbacterium sp. TPU 3598 plasmid MST3P, complete sequence	5748-5780	8	0.758
NC_013204_1	1.15\|2312187\|33\|NC_013204\|CRISPRCasFinder,CRT	2312187-2312219	33	NC_008043	Ruegeria sp. TM1040 megaplasmid, complete sequence	314254-314286	9	0.727
NC_013204_1	1.20\|2311313\|35\|NC_013204\|PILER-CR	2311313-2311347	35	NZ_CP021745	Agarilytica rhodophyticola strain 017 plasmid pSU1, complete sequence	45283-45317	9	0.743
NC_013204_1	1.33\|2312188\|34\|NC_013204\|PILER-CR	2312188-2312221	34	NC_008043	Ruegeria sp. TM1040 megaplasmid, complete sequence	314254-314287	9	0.735
NC_013204_1	1.29\|2311920\|34\|NC_013204\|PILER-CR	2311920-2311953	34	NC_019848	Sinorhizobium meliloti GR4 plasmid pRmeGR4c, complete sequence	250767-250800	10	0.706
NC_013204_1	1.29\|2311920\|34\|NC_013204\|PILER-CR	2311920-2311953	34	NC_010625	Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence	1895399-1895432	11	0.676
NC_013204_1	1.29\|2311920\|34\|NC_013204\|PILER-CR	2311920-2311953	34	NZ_CP013104	Paraburkholderia caribensis strain MWAP64 plasmid 1, complete sequence	1356262-1356295	11	0.676
NC_013204_1	1.29\|2311920\|34\|NC_013204\|PILER-CR	2311920-2311953	34	NZ_CP012748	Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence	1967462-1967495	11	0.676

1. spacer 1.10|2311853|33|NC_013204|CRISPRCasFinder,CRT matches to MG592415 (Vibrio phage 1.031.O._10N.261.46.F8, partial genome) position: , mismatch: 6, identity: 0.818

ggttatcaaaatgcgtctgttcaagttcgttta-	CRISPR spacer
ggttatgaacatgcgtctgttcaag-aagtgtat	Protospacer
****** ** ***************   ** **

2. spacer 1.24|2311583|34|NC_013204|PILER-CR matches to NZ_AP017976 (Microbacterium sp. TPU 3598 plasmid MST3P, complete sequence) position: , mismatch: 7, identity: 0.794

ccaggtac----tcgacgttctgggtgatcgcggtggg	CRISPR spacer
----ggactgcttcgatgttctgggtgatcccggtggg	Protospacer
    * **    ****.************* *******

3. spacer 1.28|2311854|34|NC_013204|PILER-CR matches to MG592415 (Vibrio phage 1.031.O._10N.261.46.F8, partial genome) position: , mismatch: 7, identity: 0.794

cggttatcaaaatgcgtctgttcaagttcgttta-	CRISPR spacer
tggttatgaacatgcgtctgttcaag-aagtgtat	Protospacer
.****** ** ***************   ** **

4. spacer 1.2|2311312|34|NC_013204|CRISPRCasFinder,CRT matches to NZ_CP021745 (Agarilytica rhodophyticola strain 017 plasmid pSU1, complete sequence) position: , mismatch: 8, identity: 0.765

ctaca-tccgtttcaacgaatcgcgtatattcctc	CRISPR spacer
-aatattccgtgtcaacgaaacgcgtatatttaac	Protospacer
  *.* ***** ******** **********.  *

5. spacer 1.6|2311582|33|NC_013204|CRISPRCasFinder,CRT matches to NZ_AP017976 (Microbacterium sp. TPU 3598 plasmid MST3P, complete sequence) position: , mismatch: 8, identity: 0.758

caggtactcgacgttctgggtgatcgcggtggg	CRISPR spacer
gactgcttcgatgttctgggtgatcccggtggg	Protospacer
 *    .****.************* *******

6. spacer 1.15|2312187|33|NC_013204|CRISPRCasFinder,CRT matches to NC_008043 (Ruegeria sp. TM1040 megaplasmid, complete sequence) position: , mismatch: 9, identity: 0.727

ccatcatgggcgctatcgtcgtggtcggcatcg	CRISPR spacer
agatcatgggcaccatcgtcgtggtctggacta	Protospacer
  *********.*.************ * *...

7. spacer 1.20|2311313|35|NC_013204|PILER-CR matches to NZ_CP021745 (Agarilytica rhodophyticola strain 017 plasmid pSU1, complete sequence) position: , mismatch: 9, identity: 0.743

tctaca---tccgtttcaacgaatcgcgtatattcctc	CRISPR spacer
---aaatattccgtgtcaacgaaacgcgtatatttaac	Protospacer
   * *   ***** ******** **********.  *

8. spacer 1.33|2312188|34|NC_013204|PILER-CR matches to NC_008043 (Ruegeria sp. TM1040 megaplasmid, complete sequence) position: , mismatch: 9, identity: 0.735

cccatcatgggcgctatcgtcgtggtcggcatcg	CRISPR spacer
cagatcatgggcaccatcgtcgtggtctggacta	Protospacer
*  *********.*.************ * *...

9. spacer 1.29|2311920|34|NC_013204|PILER-CR matches to NC_019848 (Sinorhizobium meliloti GR4 plasmid pRmeGR4c, complete sequence) position: , mismatch: 10, identity: 0.706

ccagctcgacgaacgcgacgagcg-------aaaagaggct	CRISPR spacer
cctgctcgacgaactcgacgagcgcttcgtcaag-------	Protospacer
** *********** *********       **.

10. spacer 1.29|2311920|34|NC_013204|PILER-CR matches to NC_010625 (Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence) position: , mismatch: 11, identity: 0.676

ccagctcgacgaacgcgacgagcgaaaagaggct	CRISPR spacer
ccagctcgacgaacgcgacctgcgcgtgatcaat	Protospacer
*******************  *** . ..  . *

11. spacer 1.29|2311920|34|NC_013204|PILER-CR matches to NZ_CP013104 (Paraburkholderia caribensis strain MWAP64 plasmid 1, complete sequence) position: , mismatch: 11, identity: 0.676

ccagctcgacgaacgcgacgagcgaaaagaggct	CRISPR spacer
ccagctcgacgaacgcgacctgcgcgtgatcaat	Protospacer
*******************  *** . ..  . *

12. spacer 1.29|2311920|34|NC_013204|PILER-CR matches to NZ_CP012748 (Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.676

ccagctcgacgaacgcgacgagcgaaaagaggct	CRISPR spacer
ccagctcgacgaacgcgacctgcgcgtgatcaat	Protospacer
*******************  *** . ..  . *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

911081 : 919200

Prochlorococcus_phage(33.33%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015760116.1\|911081_912584_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.5e-58	35.2
WP_049760241.1\|912689_913790_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	6.2e-62	41.4
WP_009306440.1\|913794_914415_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.9e-26	35.5
WP_009306439.1\|914513_915503_+	XdhC family protein	A0A0P0IKN7	Acinetobacter_phage	8.8e-07	27.3
WP_009306438.1\|915670_917245_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	E3SNU8	Prochlorococcus_phage	7.9e-42	50.8
WP_009607906.1\|917565_919200_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.7e-26	32.5

DBSCAN-SWA_2

3035385 : 3061495

Clostridium_phage(11.76%)

capsid,tail,terminase,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015761272.1\|3035385_3035811_+	RusA family crossover junction endodeoxyribonuclease	A0A1U9WS25	Gordonia_phage	1.5e-08	41.6
WP_015761273.1\|3035803_3036319_+	hypothetical protein	NA	NA	NA	NA
WP_015761274.1\|3036366_3036687_+	hypothetical protein	NA	NA	NA	NA
WP_015761275.1\|3036679_3037735_+	DUF1351 domain-containing protein	NA	NA	NA	NA
WP_015761276.1\|3037724_3038258_+	ERF family protein	A0A218ML85	uncultured_virus	2.4e-11	36.8
WP_015761277.1\|3038257_3038605_+	hypothetical protein	NA	NA	NA	NA
WP_015761278.1\|3038601_3039108_+	single-stranded DNA-binding protein	NA	NA	NA	NA
WP_015761279.1\|3039118_3039814_+	conserved phage C-terminal domain-containing protein	X2CYF1	Lactobacillus_phage	4.7e-07	52.9
WP_015761280.1\|3039842_3040478_+	ATP-binding protein	C5IHL4	Burkholderia_virus	7.1e-10	35.2
WP_015761281.1\|3040470_3041184_+	site-specific DNA-methyltransferase	E1AC06	Pseudoalteromonas_phage	5.7e-16	27.8
WP_015761282.1\|3041164_3041962_+	site-specific DNA-methyltransferase	A0A173G9I2	Propionibacterium_phage	2.0e-62	51.0
WP_143924748.1\|3041922_3042357_+	hypothetical protein	NA	NA	NA	NA
WP_041691666.1\|3042344_3042566_+	hypothetical protein	NA	NA	NA	NA
WP_114522536.1\|3042535_3043024_+	adenine methyltransferase	A0A2H4ERL5	Lactococcus_phage	1.7e-48	65.0
WP_015761286.1\|3043020_3043365_+	DUF4406 domain-containing protein	A0A1I9SD28	Arthrobacter_phage	2.9e-10	39.8
WP_015761287.1\|3043355_3043631_+	hypothetical protein	NA	NA	NA	NA
WP_015761289.1\|3043827_3044937_+	RNA-splicing ligase RtcB	H7BVQ6	unidentified_phage	4.9e-99	49.7
WP_015761290.1\|3044926_3045121_+	hypothetical protein	NA	NA	NA	NA
WP_041691668.1\|3045117_3045363_+	hypothetical protein	NA	NA	NA	NA
WP_015761291.1\|3045359_3045566_+	hypothetical protein	NA	NA	NA	NA
WP_015761293.1\|3045764_3045953_+	hypothetical protein	NA	NA	NA	NA
WP_015761294.1\|3045925_3046207_+	hypothetical protein	NA	NA	NA	NA
WP_015761295.1\|3046345_3048025_+\|terminase	phage terminase, large subunit, PBSX family	B6CXD2	Clostridium_phage	4.4e-75	38.3
WP_015761296.1\|3048055_3049459_+\|portal	phage portal protein	A0A1B1P863	Bacillus_phage	2.3e-32	27.6
WP_015761297.1\|3049458_3050880_+	hypothetical protein	A0A2K9V3K1	Faecalibacterium_phage	7.4e-23	29.9
WP_015761298.1\|3050869_3051070_+	hypothetical protein	NA	NA	NA	NA
WP_015761299.1\|3051253_3051796_+	hypothetical protein	NA	NA	NA	NA
WP_015761300.1\|3051822_3052716_+	hypothetical protein	A0A2H4JCM6	uncultured_Caudovirales_phage	2.6e-34	34.1
WP_015761301.1\|3052728_3052875_+	hypothetical protein	NA	NA	NA	NA
WP_015761302.1\|3052864_3053224_+	hypothetical protein	NA	NA	NA	NA
WP_015761303.1\|3053228_3053558_+	hypothetical protein	NA	NA	NA	NA
WP_015761304.1\|3053558_3053891_+	hypothetical protein	A0A2K9V3E3	Faecalibacterium_phage	4.7e-05	39.4
WP_015761305.1\|3053887_3054283_+\|capsid	minor capsid protein	NA	NA	NA	NA
WP_015761306.1\|3054282_3054987_+	Ig-like domain-containing protein	A0A2I7QIP9	Bacillus_phage	2.3e-17	42.2
WP_015761307.1\|3055086_3055545_+	hypothetical protein	NA	NA	NA	NA
WP_015761308.1\|3055516_3056191_+	hypothetical protein	NA	NA	NA	NA
WP_015761309.1\|3056183_3058601_+\|tail	phage tail tape measure protein	A0A0A7RVT5	Clostridium_phage	2.9e-75	45.8
WP_015761310.1\|3058600_3059302_+\|tail	phage tail family protein	NA	NA	NA	NA
WP_015761311.1\|3059302_3061495_+\|tail	phage tail protein	I3NL88	Bifidobacterium_phage	1.5e-83	36.4

DBSCAN-SWA_3

3368465 : 3435036

Bacillus_phage(42.86%)

holin,bacteriocin,transposase,integrase,tRNA

attL 3425912:3425931|attR 3439034:3439053

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015761447.1\|3368465_3369581_-\|tRNA	tRNA lysidine(34) synthetase TilS	NA	NA	NA	NA
WP_015761448.1\|3369580_3372238_-	EAL domain-containing protein	NA	NA	NA	NA
WP_041691770.1\|3372234_3373452_-	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	5.1e-73	40.2
WP_009305266.1\|3373528_3374179_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_015761450.1\|3374555_3375332_+	N(G),N(G)-dimethylarginine dimethylaminohydrolase	NA	NA	NA	NA
WP_015761451.1\|3375632_3377135_+	amino acid permease	NA	NA	NA	NA
WP_009305269.1\|3377288_3377657_+\|holin	phage holin family protein	NA	NA	NA	NA
WP_009305270.1\|3377878_3378382_+	CidA/LrgA family protein	NA	NA	NA	NA
WP_009305271.1\|3378387_3379086_+	LrgB family protein	NA	NA	NA	NA
WP_015761453.1\|3379656_3380829_-	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_009305273.1\|3380938_3381733_-	ZIP family metal transporter	NA	NA	NA	NA
WP_015760409.1\|3382023_3382878_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	3.2e-45	39.0
WP_009305655.1\|3382874_3383393_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_009305276.1\|3383877_3384396_-	ferritin	NA	NA	NA	NA
WP_015761454.1\|3384546_3385743_-	hypothetical protein	NA	NA	NA	NA
WP_015761455.1\|3385971_3386865_-	polysulfide reductase NrfD	NA	NA	NA	NA
WP_009305279.1\|3386871_3387414_-	4Fe-4S dicluster domain-containing protein	NA	NA	NA	NA
WP_015761456.1\|3387413_3389615_-	molybdopterin-dependent oxidoreductase	NA	NA	NA	NA
WP_009305281.1\|3389629_3390364_-	molecular chaperone TorD family protein	NA	NA	NA	NA
WP_009305282.1\|3390444_3391206_-	ferredoxin-like protein	NA	NA	NA	NA
WP_009305283.1\|3391588_3393718_+	aldehyde ferredoxin oxidoreductase	NA	NA	NA	NA
WP_009305284.1\|3393844_3394438_-	iron-sulfur cluster assembly scaffold protein	NA	NA	NA	NA
WP_009608516.1\|3394535_3395582_-	hypothetical protein	NA	NA	NA	NA
WP_015761458.1\|3395729_3397283_+	LuxR family transcriptional regulator	NA	NA	NA	NA
WP_041691771.1\|3397406_3398627_+	4Fe-4S binding protein	NA	NA	NA	NA
WP_015761460.1\|3398695_3399733_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_015761461.1\|3399871_3400783_-	acetamidase/formamidase family protein	A0A1V0S8X7	Catovirus	3.8e-12	26.9
WP_158539342.1\|3400928_3402272_+	hypothetical protein	NA	NA	NA	NA
WP_015761463.1\|3402485_3404024_+	FAD-binding protein	NA	NA	NA	NA
WP_015761464.1\|3404102_3405557_-	sodium-dependent transporter	NA	NA	NA	NA
WP_015761465.1\|3405783_3407262_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_015761466.1\|3407466_3409032_+	flavocytochrome c	M1HTN0	Paramecium_bursaria_Chlorella_virus	3.7e-23	27.2
WP_009305293.1\|3409252_3409540_-	hypothetical protein	NA	NA	NA	NA
WP_009305294.1\|3409965_3410244_-	hypothetical protein	NA	NA	NA	NA
WP_009305295.1\|3410275_3410698_-	ATP-binding protein	NA	NA	NA	NA
WP_015761467.1\|3410702_3411008_-	STAS domain-containing protein	NA	NA	NA	NA
WP_114522558.1\|3411010_3412849_-	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_057385068.1\|3412911_3413148_-	hypothetical protein	NA	NA	NA	NA
WP_009608472.1\|3413189_3413381_+	hypothetical protein	NA	NA	NA	NA
WP_009608429.1\|3413490_3414078_+	hypothetical protein	NA	NA	NA	NA
WP_015761469.1\|3414188_3417836_+	S8 family serine peptidase	A0A127AWU5	Bacillus_phage	1.4e-17	36.1
WP_015761470.1\|3417963_3418182_+	hypothetical protein	NA	NA	NA	NA
WP_015761471.1\|3418240_3419182_-	hypothetical protein	NA	NA	NA	NA
WP_009305303.1\|3419507_3419768_-	hypothetical protein	NA	NA	NA	NA
WP_015761472.1\|3419816_3421988_-\|bacteriocin	NHLP bacteriocin export ABC transporter permease/ATPase subunit	F2Y2R6	Organic_Lake_phycodnavirus	3.5e-16	29.7
WP_041691681.1\|3422000_3424145_-\|bacteriocin	NHLP family bacteriocin export ABC transporter peptidase/permease/ATPase subunit	W8CYL7	Bacillus_phage	4.7e-29	25.6
WP_009608476.1\|3424198_3424708_-	hypothetical protein	NA	NA	NA	NA
WP_009305307.1\|3424704_3424992_-	hypothetical protein	NA	NA	NA	NA
WP_015761474.1\|3425362_3425728_-	Nif11-like leader peptide family natural product precursor	NA	NA	NA	NA
WP_009305310.1\|3425762_3426068_-	hypothetical protein	NA	NA	NA	NA
3425912:3425931	attL	NA	NA	NA	NA
WP_035578662.1\|3426492_3427275_+	LytTR family transcriptional regulator	NA	NA	NA	NA
WP_015761477.1\|3427952_3428321_-	Nif11-like leader peptide family natural product precursor	NA	NA	NA	NA
WP_009305314.1\|3428333_3428726_-	Nif11-like leader peptide family natural product precursor	NA	NA	NA	NA
WP_015761478.1\|3428722_3430150_-	radical SAM protein	NA	NA	NA	NA
WP_009608461.1\|3430208_3430556_-	hypothetical protein	NA	NA	NA	NA
WP_041691682.1\|3430683_3430998_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_114522555.1\|3431161_3431380_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_143924750.1\|3431539_3432898_+	hypothetical protein	NA	NA	NA	NA
WP_009307321.1\|3433917_3435036_+\|transposase	IS256-like element ISEle1 family transposase	NA	NA	NA	NA
3439034:3439053	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_013204

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection