CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_013595	Streptosporangium roseum DSM 43021, complete sequence	60 crisprs	cas3,WYL,Cas14u_CAS-V,c2c10_CAS-V-U3,csa3,DEDDh,c2c9_V-U4,cas4,DinG	7	23	4	0
NC_013596	Streptosporangium roseum DSM 43021 plasmid pSROS01, complete sequence	0 crisprs	NA	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_013595_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_1

5689-5769

Orphan

Consensus_repeat	Method
CTCCCGCGGGGCGCGAGCCGTACGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_1

>merge|NC_013595|1|5689-5769|CRISPRCasFinder
CTCCCGCGGGGCGCGAGCCGTACGGTGACGAACACCTCGGAGTCGGGATCGGCGTGCTCCCGCGGGCGCGAGCCGTACGGT

>NC_013595|1|1|5689-5769|CRISPRCasFinder
CTCCCGCGGGGCGCGAGCCGTACGGT	GACGAACACCTCGGAGTCGGGATCGGCGT
GCTCCCGCGGGCGCGAGCCGTACGGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012886812.1\|4647_5589_+\|decarboxylating-6-phosphogluconate-dehydrogenase	unknown	unknown	gnl\|CDD\|236582
NC_013595.1\|WP_012886816.1\|9949_12460_+\|DNA-gyrase-subunit-A	unknown	unknown	gnl\|CDD\|235502
NC_013595.1\|WP_012886822.1\|17861_19283_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_013595.1\|WP_169369519.1\|12694_13180_+\|DUF3566-domain-containing-protein	unknown	unknown	gnl\|CDD\|378809
NC_013595.1\|WP_012886823.1\|19378_19660_+\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197385
NC_013595.1\|WP_012886819.1\|14831_16088_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_013595.1\|WP_012886815.1\|7963_9907_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	unknown	unknown	gnl\|CDD\|235542
NC_013595.1\|WP_012886811.1\|3883_4615_+\|3-keto-5-aminohexanoate-cleavage-protein	unknown	unknown	gnl\|CDD\|225785
NC_013595.1\|WP_012886821.1\|17424_17706_+\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328
NC_013595.1\|WP_012886810.1\|2671_3811_+\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|236089
NC_013595.1\|WP_012886820.1\|16097_16709_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012886813.1\|5884_7057_+\|DNA-replication/repair-protein-RecF	unknown	unknown	gnl\|CDD\|234608
NC_013595.1\|WP_012886809.1\|360_2109_+\|chromosomal-replication-initiator-protein-DnaA	unknown	unknown	gnl\|CDD\|237605
NC_013595.1\|WP_148269424.1\|7205_7667_+\|DUF721-domain-containing-protein	unknown	unknown	gnl\|CDD\|179552

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012886812.1\|4647_5589_+\|decarboxylating-6-phosphogluconate-dehydrogenase	gnl\|CDD\|236582	PRK09599, PRK09599, NADP-dependent phosphogluconate dehydrogenase.	0
NC_013595.1\|WP_012886816.1\|9949_12460_+\|DNA-gyrase-subunit-A	gnl\|CDD\|235502	PRK05560, PRK05560, DNA gyrase subunit A; Validated.	0
NC_013595.1\|WP_012886822.1\|17861_19283_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.18162e-53
NC_013595.1\|WP_169369519.1\|12694_13180_+\|DUF3566-domain-containing-protein	gnl\|CDD\|378809	pfam12089, DUF3566, Transmembrane domain of unknown function (DUF3566). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 136 to 304 amino acids in length. This region represents a transmembrane region found at the C-terminus of the proteins.	5.05528e-50
NC_013595.1\|WP_012886823.1\|19378_19660_+\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|197385	cd10148, CsoR-like_DUF156, Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156. This superfamily includes various transcriptional regulators that respond to stressors including Cu(I), Ni(I), sulfite, and formaldehyde. It includes CsoR (copper-sensitive operon repressor) from Mycobacterium tuberculosis (MtCsoR), Bacillus subtilis (BsCsoR), Thermus thermophilus (TthCsoR), and Staphylococcus aureus (SaCsoR), Mycobacterium tuberculosis RicR (regulated in copper repressor, MtRicR), Escherichia coli RncR (formally known as YohL, nickel and cobalt-sensitive), Alcaligenes xylosoxidans NreA (nickel-sensitive), E. coli FrmR (formally known as YaiN, formaldehyde sensitive), and Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor, NWMN_0026.5, SaCstR). CsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis. For example, TthCsoR binds the promoter region of the copZ-csoR-copA operon, and represses expression of these genes, which encode the copper chaperone CopZ, CsoR, and the copper efflux P-type ATPase CopA, respectively. In the presence of excess Cu(I), TthCsoR binds this ion, and is released from the DNA, allowing expression of the downstream genes. TthCsoR also senses other metal ions such as Cu(II), Zn(II), Ag(I), Cd(II) and Ni(II). CsoRs form a homotetramer (dimer of dimers). In the case of MtCsoR, two Cys residues on opposite subunits within each dimer, along with a His residue, bind the Cu(I) ion. These residues are conserved in the majority of members of this superfamily. Exceptions include the functionally uncharacterized Bacillus subtilis YrkD where there is an Asn instead of His (C-N-C), E.coli RcnR where there is a Thr instead of the second Cys (C-H-T), or TthCsoR and E.coli FrmR where there is a His instead of the second Cys and which have an additional N-terminal His (not found in those family members having C-H-C) that may also be involved in metal binding (H-C-H-H). A conserved Tyr and a Glu residue facilitate allosteric regulation of DNA binding. SaCstR regulates genes predicted to function in sulfur metabolism; it is thought that oxidation of the intersubunit Cys pair to a mixture of disulphide and trisulphide linkages by sulfite, results in a reduced affinity of SaCstR for the operator DNA. SaCstR exists as a mixture of oligomeric states, including dimers, tetramers and octamers. The sequence of SaCstR was not available at the time this hierarchy was curated and therefore was not included. Escherichia coli RncR represses expression of the gene encoding the nickel and cobalt-efflux protein RcnA. The gene encoding Alcaligenes xylosoxidans NreA is part of the nre nickel resistance locus located on the pTOM9 plasmid from thisbacteria. Escherichia coli FrmR regulates the formaldehyde degradation frmRAB operon.	1.66709e-28
NC_013595.1\|WP_012886819.1\|14831_16088_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	0.00455268
NC_013595.1\|WP_012886815.1\|7963_9907_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	gnl\|CDD\|235542	PRK05644, gyrB, DNA gyrase subunit B; Validated.	0
NC_013595.1\|WP_012886811.1\|3883_4615_+\|3-keto-5-aminohexanoate-cleavage-protein	gnl\|CDD\|225785	COG3246, COG3246, Uncharacterized conserved protein [Function unknown].	1.42073e-24
NC_013595.1\|WP_012886821.1\|17424_17706_+\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	2.10557e-15
NC_013595.1\|WP_012886810.1\|2671_3811_+\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|236089	PRK07761, PRK07761, DNA polymerase III subunit beta; Validated.	0
NC_013595.1\|WP_012886813.1\|5884_7057_+\|DNA-replication/repair-protein-RecF	gnl\|CDD\|234608	PRK00064, recF, recombination protein F; Reviewed.	9.93233e-141
NC_013595.1\|WP_012886809.1\|360_2109_+\|chromosomal-replication-initiator-protein-DnaA	gnl\|CDD\|237605	PRK14086, dnaA, chromosomal replication initiator protein DnaA.	0
NC_013595.1\|WP_148269424.1\|7205_7667_+\|DUF721-domain-containing-protein	gnl\|CDD\|179552	PRK03195, PRK03195, DUF721 family protein.	1.31567e-28

>NC_013595.1|WP_012886812.1|4647_5589_+|decarboxylating-6-phosphogluconate-dehydrogenase
MQIGMVGLGKMGGNMAERLRRGGHDVVGYDRDPAVSDVSSLKDLVDRLQEPRAVWVMVPAGAPTQATVEELGNLLSAGDIVIDGGNSHYLDDQKHAAELGAKKIGFVDCGVSGGIWGLENGYALMVGGSKPDIERLMPIFETLRPEEGGFVHAGDVGAGHFAKMVHNGIEYGMMQAFAEGWELLEASDVVTDVPGAFKSWRHGTVIRSWLLDLMVRALDEDPALAELKGYAQDSGEGRWTVQAAVDHAVPLPVITAALYARFASRQEDSPAMKVVAALRNQFGGHAVTAKEGEFAKGADAPGADVVPPVEVDK
>NC_013595.1|WP_012886811.1|3883_4615_+|3-keto-5-aminohexanoate-cleavage-protein
MTMIKACLNGSRKAGEHPALPLTPLELAEAAREAREAGAAAVHMHPRDEAGSESLSAVHIGAAVRAVRRACPGLPVGVSTGLWISGGDVEARREAVRGWAALPARDRPDFASVNLSEPGFSDLWHDLRRLGVGVEAGVWSVDDADALASTGLECVRVLVEIIGGSADTAVSRAHAVLGRLDELSVPGPRLLHGEEGPAWILVDEAGQLGLAARIGLEDVLHSPVGDPVDGNADLVRLALARRV
>NC_013595.1|WP_012886810.1|2671_3811_+|DNA-polymerase-III-subunit-beta
MMFRIERDVLAEAVAWTARSLPARPSVPVLAGMRLEVTEKGQLKLSGFDYEVSAEVTLEPQSGEAGVVLVSGRLLAEITRALPAQPVDFVVEGAKAVVTCGSARFTLLTMPVEDYPSLPTMPPAAGRVGSDVFASAVGQVAVAAGKDDTLPMLTGVRMEIEGDTVTLAATDRYRLAVRELKWQPGQPDFSAIAMIPGKTLADAAKALGSTGAEVEVAMSSVGGTGEGMIGFSSAGRRTTTRLLDPEFPKYRSLLPTEFSARADLSTSAFVEAVKRVALVAERNTPVRLAFRGDEVVLEAGSGDEAQAVEVLPVDFEGDDINIAFNHQFLLEGLGAIDSDVARLQMTTSTKPAILTGGKHVDDGGVPDYRYLIMPIRLSS
>NC_013595.1|WP_012886809.1|360_2109_+|chromosomal-replication-initiator-protein-DnaA
MDAMDLGAVWARALENSLNESVPSQQRVWLSMTRPFGLMNDTVVLAAPNDFARDVLEDKLRPLISHALSQEFGRPMRVAVMVDPSATGSDSGVASRPESYPQAPPTSYPQSGGPQQSYAQPVTSQHHSASGAQHPYPAAGTAAPPSTEYPQHQPQAQPFSYSYQHRDEQAQPYLPAEPSPAPPPAEQGGGYGRGGYTPRPSPPSRSEPDTFERPAQSPGAGGVHNRWDSRGSRTQGEPARLNPKYTFETFVIGSSNRFAHAAAVAVAEAPAKAYNPLFIYGDSGLGKTHLLHAIGHYAQSLYDGARVRYVSSEEFTNDFINSIRDHKADGFRSRYRAVDILLVDDIQFLEGKEQTQEEFFHTFNTLHNANKQIVISSDRAPKQLVTLEDRLRNRFEWGLITDVQPPELETRIAILRKKAIQEGLAAPPEVLEYIASRISTNIRELEGALIRVTAFASLNRQSVDLQLTEVVLKDLITEDAGSEITVATIMASTAAYFGLSIDDLCGGSRSRVLVTARQIAMYLCRELTDMSLPKIGQQFGGRDHTTVMHADRKIRSLMAERRSIYNQVNELTTRIKQQSRNG
>NC_013595.1|WP_012886813.1|5884_7057_+|DNA-replication/repair-protein-RecF
MHVANLSLTDFRSYDTVDLGLEPGVTAFVGPNGQGKTNLVEALGYVATQSSHRVATDGPLVRQGAARAIVRSVVVREDRRALIELEINPGKANRARLNRSPVSRPRDVIGLLRTVLFAPEDLSMVKGDPSERRRYLDDLLVARTPRFAGVRADYDRVLKQRGALLRTAAQARRGGRSGRRADNDAAFAAAGAGDPLSTLEVWDAHLARHGAELLAARLELVEALRPLVAASYAALAPNSAPAALEYRGTLSTEEGSDRATLEERLRAGLLEVRTSEIERGVTLVGPHRDDLFLGLGELPARGYASHGESWSFALALRLAAYDLLRADGGDPVLILDDVFAELDNQRRGRLAGIVAPAEQVLITAAVAADVPAELVGARFDVTEGSVHRVR
>NC_013595.1|WP_148269424.1|7205_7667_+|DUF721-domain-containing-protein
MAREKLAQAKADAAKRGQLPRREPRRRAAGPRRDFGDPQLFGRAITDLLADRGWEQPVAVGGVFGRWHEIVGPDLAAHTKPETFADGEVLVVADSTAWATQVRLLARTLVRRLNEELGDGTVQRVKVRGPQNGPRPSGGLRVTGSRGPGDTYG
>NC_013595.1|WP_012886815.1|7963_9907_+|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B
MSYDASSITVLEGLEAVRKRPGMYIGSTGERGLHHLVYEVVDNSVDEALAGHADRIEVTLLADNGVRVVDNGRGIPVGIVEAEGRPAVEVVLTVLHAGGKFDSKSYAVSGGLHGVGVSVVNALSSKLEVEIRTDGHHWQQSYAETRPLHPLVKGEATEETGTSITFWADSTIFETTTWNFETLSRRFQEMAFLNKGLTISLRDERPDHINGEPKEATYHYEGGLSDFVKHLNSKKEPAHVSVIDFEESGEGISVEIAMQWNNSYSESVYTFANTINTAEGGTHEEGFRAALTSIVNRYAREQKFLKEGKDDNLAGEDIREGLTAIISVKLADPQFEGQTKTKLGNTEAKSFVQKACNDHLRDWFERNPGEAKDIINKSLQASRARLAARQARDLTRRKSLLESGSGLPGKLADCQWSDPEKCELFIVEGDSAGGSAKGGRDSKFQAILPIRGKILNVEKARIDKVLRNTEVQALITAMGTGVHDEFDITKLRYHKLILMADADVDGQHINTLLLTLLFRFMRPLIEAGHVYLSQPPLYKIKWDRRGEDASYAYSDPERDAIIADGIARGKRDPRMHDGIQRFKGLGEMNASQLWETTMNPETRVLRLVTLDDAAQADELFSVLMGEDVEARRSFIIRNARDVRFLDV
>NC_013595.1|WP_012886816.1|9949_12460_+|DNA-gyrase-subunit-A
MTDVNTPLVERIEPVDIQSEMQRSYMDYAMSVIVSRALPDVRDGLKPVHRRVLYAMYDGGYRPDRGYFKCSRVVGDVMGSYHPHGDSSIYGTVVRLAQPWALRYTLIDGQGNFGSPGNDMPAAMRYTECKLAPIAMEMIRDIDKDTVDFQPNYDGRSQEPLVLPSRFPNLLVNGSAGIAVGMATNIPPHNLREVADGVRWALQNPEASDEELLEALIARVKGPDFPTGALIVGRRGIDDAYRTGRGSITMRAIVEVEEDAKGRQCLVVTELPYQVNPDNLALSIAESVKEGRITGIADVRDESSSRVGQRLVIVLKRDAVAKVVLNNLYKHTQLQTTFGANMLALVDGVPRTLRLDQFVRHYVAHQIEVVVRRTRYLLRKAEERAHILRALLKALERMDEVIALIRRSPSASAAQGGLMALLEIDEIQAQAILDMQLRKLAALERQQITDEYDTLMAHITDYQAILASPERQRTIVFDELSEIVSKYGDERKTEIIAYEGDMSIEDLLAEEDMVVTITRGGYAKRTNTDLYRAQKRGGKGVRGAQLRQDDIVDHFFVTTTHHWLLFFTNKGRVYRVKAYELPDSGRDARGQHLANLLAMQPDEVVMEVLDLRDYEVAPYLVLATRSGLVKKTRLSEYDSPRSGGLIAINLREDDEVIAARLVSEEDDLLLVSRGAQSIRFTASDEALRPMGRATSGVIGMRFLGGDELLAMNRIGDGDDVLIATEGGYAKRTPADQYPVQGRGGKGVLTAKIVSARGKLVGAAMVRPEDEVFAITSAGGVIRTSAGEIKQSGRQTMGVRLMNLAEGDSVVALARNAEALETEHNDALETEQNGEGE
>NC_013595.1|WP_169369519.1|12694_13180_+|DUF3566-domain-containing-protein
MRPRSAETDSSSWAPGGLSSPAPEAPGRKAADPSPRAPRKAHLVLRRIEPWSAMKFSFVVSLVCFVVLFVAVAVLYMVLSGLGVFDNIIQTVNQLTTADGKSTSGVDVASWFEPVRILGYTALIGAVNVVLITALSTLGSVIYNIASDLVGGVEVTFSEAE
>NC_013595.1|WP_012886819.1|14831_16088_+|helix-turn-helix-transcriptional-regulator
MGTPGTPPEWAARLREKRKAKVGTVADMARRLKEAAGEQRGRLPSIDDLTRTIRGWERGDHYPSERYRLLYARALRTTEAELFDLAERPSVPVPALPLPSVAPDADLFERIARSVQQPSRVDQRTVDWLAICLAEHRKVEDTIGARPLLGIVRSQLGVVVELAQHARGSLADTVVDLAAQYAQFVAWMSLDVDDQAAALAWYDRAHDWALEIGDVNMATTTLSMKAHQAWSAGNARRCVRLADAARRHDGQVTPGVRGMAAQMAARGHALAGDARPARTLLDEAEALIRQAAEHADDEPVWMYFYDETWFRLQRGMTELQLGNWSKAIDLLTDGLSGLPESYKRDRAWYGSCLAKAHAEAGDAAAAVQVSLPIMADAVALNRHARKELIDVAALITNRRSPQGGLLEEALAAADRRNG
>NC_013595.1|WP_012886820.1|16097_16709_-|hypothetical-protein
MTSSPAEFHWLSDEGPLDDIFCISFIRGLPPLEVLARLGVDEITIKEMTFDEFNELAVEQWISTGGDAPDYVGAVKLGNWAILVEPLGWRVPTYPNVLNRLSEGTEVVSVSRHEYASDEFVHVINRDVIVRFDPLSPQYRTGVDPKRWEAVMARVGLGPFTSDDSMPDDPIASAFALASEITGVSFTADVLDQPFLVAVATTE
>NC_013595.1|WP_012886821.1|17424_17706_+|heavy-metal-associated-domain-containing-protein
MCTACACGTQDSTAAQVEITEGKVYTVSGMTCGHCVSSVSAEVESVGGVTGVQVDLATGLVTVSGTGFSDEEIRAAVEQAGYTLAGASPVGAS
>NC_013595.1|WP_012886822.1|17861_19283_+|MFS-transporter
MNAVNPRRWQALIVLAAAQFMVIMDTSIIGVALPDMQRDLGFSQGSLQWVFNAYVVAFGGLLLLGGRLSDLFGARKIFTTGWVILIAGSVVAAAAGNAWVEILGRAVQGVGGALIAPAAMTLLMMLFGHNPRELGKAMALYGAAAPAGGTAGVFLGGVITQYLSWPWVFIIYVPIGLATLAAVPALLPATQGKRGSVDVLGAIAVTAGIALAVYTIVSAPEQSLTITLIEGVGAAVLLGLFLVIQRSVREPLMPLKIWKAPGLAAANLAMALLGAAWIPMWYFLNLYLQQVLGYGAFASGAALLPMTVAIMIFMIGITARLLGKFGAKPLIVLGLLVLAAGVAGLSLVRPDGAFVSDVLPASLIAAVGMSLAYIPAMMSAMSGARPEESGLASGIVNTTYNVGSALGLAVMTAVATSQGAAEMGNLLKLTDGFQAAFVGAGVLAAGGAVLTLALMRRPGRAVQEGPVTEKTGA
>NC_013595.1|WP_012886823.1|19378_19660_+|metal-sensitive-transcriptional-regulator
MAGCGDRKQGLAMRLRRVEGQVRGLQRMVEDDKYCIDTLTQVSAVTSALRSFALSLLEDHVAQCVTAPAPKGGPETTARVKEATDAIARLVRS

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Crispr_ID: NC_013595_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_2

123832-123952

Orphan

Consensus_repeat	Method
TGCGGCGCCGTACGGGGGTGGAAGGTCAAAAGCGCAGCGAGGGGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_2

>merge|NC_013595|2|123832-123952|CRISPRCasFinder
TGCGGCGCCGTACGGGGGTGGAAGGTCAAAAGCGCAGCGAGGGGTGGATGGAGTGGCCGGGGGCCGGCCCATCCATGCGGCGCCGTACGGGGGTGGAAGGTCAAAAGCGCAGCGAGGGGTG

>NC_013595|2|2|123832-123952|CRISPRCasFinder
TGCGGCGCCGTACGGGGGTGGAAGGTCAAAAGCGCAGCGAGGGGTG	GATGGAGTGGCCGGGGGCCGGCCCATCCA
TGCGGCGCCGTACGGGGGTGGAAGGTCAAAAGCGCAGCGAGGGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012886919.1\|119583_120618_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NC_013595.1\|WP_012886926.1\|127337_128684_+\|cytosine-permease	unknown	unknown	gnl\|CDD\|274096
NC_013595.1\|WP_012886924.1\|125949_126555_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|381701
NC_013595.1\|WP_012886914.1\|113624_115082_-\|peptidoglycan-glycosyltransferase	unknown	unknown	gnl\|CDD\|274573
NC_013595.1\|WP_012886918.1\|118269_119010_-\|DUF3662-and-FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|378850
NC_013595.1\|WP_012886928.1\|129399_131322_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|274368
NC_013595.1\|WP_012886913.1\|112218_113628_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012886923.1\|125355_125934_+\|DM13-domain-containing-protein	unknown	unknown	gnl\|CDD\|378440
NC_013595.1\|WP_012886917.1\|117784_118252_-\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NC_013595.1\|WP_012886920.1\|120614_122075_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NC_013595.1\|WP_052316833.1\|131478_131934_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NC_013595.1\|WP_012886915.1\|115078_116458_-\|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl\|CDD\|223843
NC_013595.1\|WP_012886929.1\|132012_132708_-\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|376730
NC_013595.1\|WP_148268904.1\|122673_123645_+\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NC_013595.1\|WP_012886930.1\|132778_133045_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012886922.1\|124585_125245_-\|GPP34-family-phosphoprotein	unknown	unknown	gnl\|CDD\|377552
NC_013595.1\|WP_012886927.1\|128740_129325_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|223427
NC_013595.1\|WP_174435242.1\|126838_127162_+\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NC_013595.1\|WP_012886912.1\|110279_112136_-\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012886916.1\|116462_117788_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|223704

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012886919.1\|119583_120618_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	8.83023e-79
NC_013595.1\|WP_012886926.1\|127337_128684_+\|cytosine-permease	gnl\|CDD\|274096	TIGR02358, purine-cytosine_transport_protein, putative hydroxymethylpyrimidine transporter CytX. On the basis of a phylogenomic study of thiamine biosythetic, salvage, and transporter genes and a highly conserved RNA element THI, this protein family has been identified as a probable transporter of hydroxymethylpyrimidine (HMP), the phosphorylated (by ThiD) form of which gets joined (by ThiE) to hydroxyethylthiazole phosphate to make thiamine phosphate. [Transport and binding proteins, Nucleosides, purines and pyrimidines, Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine].	7.96338e-47
NC_013595.1\|WP_012886924.1\|125949_126555_+\|transcriptional-regulator	gnl\|CDD\|381701	cd19366, TenA_C_BhTenA-like, TenA_C proteins similar to Bacillus halodurans TenA. This family of TenA proteins belongs to the TenA_C class as it has a conserved active site Cys residue; the double Glu residues identified in the active site of TenA_E from the archaeon Pyrococcus furiosus is conserved in this family. TenA_C proteins (EC 3.5.99.2) catalyze the hydrolysis of the thiamin breakdown product 4-amino-5-amino-methyl-2-methylpyrimidine (amino-HMP) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in a thiamin salvage pathway. This family includes Bacillus halodurans TenA which participates in a salvage pathway where the thiamine degradation product 2-methyl-4-formylamino-5-aminomethylpyrimidine (formylamino-HMP) is hydrolyzed first to amino-HMP by the YlmB protein, and the amino-HMP is then hydrolyzed by TenA to produce HMP. It has also been suggested that TenA proteins act as transcriptional regulators based on changes in gene-expression patterns when TenA is overexpressed in Bacillus subtilis, however this effect may be indirect.	1.56874e-51
NC_013595.1\|WP_012886914.1\|113624_115082_-\|peptidoglycan-glycosyltransferase	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	1.55901e-97
NC_013595.1\|WP_012886918.1\|118269_119010_-\|DUF3662-and-FHA-domain-containing-protein	gnl\|CDD\|378850	pfam12401, DUF3662, Protein of unknown function (DUF2662). This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with pfam00498.	3.58844e-48
NC_013595.1\|WP_012886928.1\|129399_131322_+\|PAS-domain-S-box-protein	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	3.03901e-42
NC_013595.1\|WP_012886913.1\|112218_113628_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.39585e-119
NC_013595.1\|WP_012886923.1\|125355_125934_+\|DM13-domain-containing-protein	gnl\|CDD\|378440	pfam10517, DM13, Electron transfer DM13. The DM13 domain is a component of a novel electron-transfer system potentially involved in oxidative modification of animal cell-surface proteins. It contains a nearly absolutely conserved cysteine, which could be involved in a redox reaction, either as a naked thiol group or through binding a prosthetic group like heme.	2.00616e-33
NC_013595.1\|WP_012886917.1\|117784_118252_-\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	4.96329e-19
NC_013595.1\|WP_012886920.1\|120614_122075_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	5.44485e-114
NC_013595.1\|WP_052316833.1\|131478_131934_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	8.26039e-20
NC_013595.1\|WP_012886915.1\|115078_116458_-\|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl\|CDD\|223843	COG0772, FtsW, Bacterial cell division membrane protein [Cell division and chromosome partitioning].	4.0232e-72
NC_013595.1\|WP_012886929.1\|132012_132708_-\|membrane-protein-insertase-YidC	gnl\|CDD\|376730	pfam02096, 60KD_IMP, 60Kd inner membrane protein.	8.1862e-32
NC_013595.1\|WP_148268904.1\|122673_123645_+\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	7.24238e-58
NC_013595.1\|WP_012886922.1\|124585_125245_-\|GPP34-family-phosphoprotein	gnl\|CDD\|377552	pfam05719, GPP34, Golgi phosphoprotein 3 (GPP34). This family consists of several eukaryotic GPP34 like proteins. GPP34 localizes to the Golgi complex and is conserved from yeast to humans. The cytosolic-ally exposed location of GPP34 predict a role for a novel coat protein in Golgi trafficking.	6.25511e-51
NC_013595.1\|WP_012886927.1\|128740_129325_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	7.94842e-38
NC_013595.1\|WP_174435242.1\|126838_127162_+\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	2.98525e-26
NC_013595.1\|WP_012886912.1\|110279_112136_-\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.92569e-132
NC_013595.1\|WP_012886916.1\|116462_117788_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	3.5292e-70

>NC_013595.1|WP_148268904.1|122673_123645_+|LCP-family-protein
MTWRPKRPGRLIARILIGLLVVLLVLAVGGYFVINSRLTRIEALTDYDGRPADTPGTNWLLVGSDSRAGLTKAQRRKLATGSSVGRRTDTMMLLHIPDTGDRPTLVSLPRDSYVPIDGHGSGKLNAAYAYQDGGPKLLAKTVEKVTGLRIDHYMEIGFGGFVGIVDAIGGVEINVKQAIKDPKAGIDLKKGLQTMDGGTALGYVRTRATGAIPDFDRTQRQRQFFSAVVKKAASPGVLINPFRSIPLALSATDSVAVGEESGAFNLLSLGLAMGDNPVTTVVPVGSLPTINGEAVVKWDTAKALRMFDALAEDRPVPKDALGK
>NC_013595.1|WP_012886920.1|120614_122075_-|HlyC/CorC-family-transporter
MNTALGLLAVLLLTLATGYFVAQEFAFVAADRGVLREQAEAGDAAAKRALEVTGRLSFMLSGAQLGITVTALLVGFIAEPAIATVIRPGLEAAGVPEAAVPGIAVALAIAVATVVQMVLGELAPKNLGIARPEPVAKFLSGSTIVYLKIAGPVIRLFDSAATGLLRRVGVEPVEEVEHGASPEELSRIISESATAGDLPPRLSELLERALEFGDRTAEDVMVPRPRVVLLRAERPISDLLDAVREHGHSRYPVLCKDNGEDVVGVTGVRELLKSGLTDGSLEEITRPALLVPDSLPLPVVLERMRAAGDDLACVIDEYGGLAGVVTVEDLAEELVGELIDENDPEPAGVVANDDGTWDLPGTLRLDEVERATKLELPESDGYETIAGLVLATLGRMAEPGDQVTVTLTLETDLLENDSADEADAVLTVLSVHRRVPEWVRLAPAAAEVPGKAEVPGKNGEHAMAAPRMIDRGADRPMIERSVVDGR
>NC_013595.1|WP_012886919.1|119583_120618_-|HlyC/CorC-family-transporter
MSTTGALLLGVALLIGNAFFVAAEFAVISARRHRLEELAGKGGRLTRVSARAAVRGGRELSLMLAGAQFGITLCSLGLGMVTEPAIEHLLEPVFALVGLPESLQVPISLVIALALVTFLHMVIGEMAPKSWALTHPEIAAMSLALPFRGFTWLIRPVLSSLNGLTNALLRVFGVHARDELATTRTPVQLAMLVGESGRMGLLDRDEHDLLTRALRVHQQPVERLMLPIGEATCVTGDATETQVRRAAADSGHLRLLVNSGRPADVLGVLHVRDVLVRPGASPAELARPVPRLEKSTTIPEAVSVLQEAHAHVGLVTDGGGEVAGMVSLTDLLGELLDVRILATR
>NC_013595.1|WP_012886918.1|118269_119010_-|DUF3662-and-FHA-domain-containing-protein
MGVLQRFERRLEGLVEGAFARAFKSDLQPVEVASAVQREMDERAAIVAQGRTLVPNDFVVELSTTDSERLEVYADSISLELANLAREYAKEQGYSFVGPVRVRFETADDLAVGLFRIRSGVIRGATVEQDEIRQPVSDVPAAKPHAFGGRPRLLVSTQDDPQGQRSYDLTTPVTLLGRGTDCDLRLVDPGVSRHHAELRVEGPQVVLVDLGSTNGTFVNGQPVRRVELQNGTRVTLGRTTLVFRRD
>NC_013595.1|WP_012886917.1|117784_118252_-|FHA-domain-containing-protein
MSELTLLLIRLAFLALLWFFVIAAVGVIRTDLFGSRTTTAAPARKAPKPVKPAAKPKKGEPRQMVVIGGPLQGTTITLSETPITIGRANDATLVVSDDYASSRHARLFPQDGQWIVEDLGSTNGTYLDRSKVTRPTPVPLGVPIRIGKTVIELRK
>NC_013595.1|WP_012886916.1|116462_117788_-|serine/threonine-protein-phosphatase
MTIALRYAARSDVGLLREGNEDSAYASGRLLAVADGMGGHAHGEVASSVAIAAMSSLDEDPQGGDLLSAVEAAVRDANRRLHEMVGRDPSLKGMGTTLTAMLWSGTRVALVHVGDSRAYLLRAGELYQITHDHTLVQSLVDDGRITLEEAATHPQRSILLRALDGSGEVDPDLSLREAQVGDRYLLCSDGLSGVVSAETMHHTLSTIEDPETVVRTLIDLANRGGGPDNITCVLADVLEVDEGLALPVEAAVVGAAGSTRPRTQLPDTPAGHAAGITMPQPVITDDDLEEPVARATGRPARRRRLWPLMASVGGVVLVGGGLGWYFGSQWLDDQYFVGVKGDEIVVFQGVKTNLGPIELFDVARSTTESVTALGAFQQGQVRDGIPVASVDEGLKKIEELKTSAAKPATKPTAKPESKPDGKGKQTSQPSGTASPEPTRSQ
>NC_013595.1|WP_012886915.1|115078_116458_-|FtsW/RodA/SpoVE-family-cell-cycle-protein
MSTPSVEPVPLPAKRRLAQLAMLAFAVVIVMFAYANVGLAIDKQIPSGMLTYGLSLGGFMLAAYLVLARFAPWADPLILPLVTLVNGLGLVMIYRLEQSKAFGASANTQLLWTAVGVVLFSVTLIVLRDHRALQRLTYTAGAVGLLLLISPLLPFIGKNINGARIWIEIPGVGQLQPAEFAKLALIVFFAGYLVAKRDVLALAGRRLLFIDLPRARDLGPILIVWGFSLGVLILQKDLGSSLLIFGTFIAMLYIATQRTSWVLIGILLFVGGAILAGMVFDHVHARFEVYLNPEDPELFQKVGGSEQLMQGLFAMAAGGILGTGLGQGHPDKIPLAISDFIFPATGEELGLTGLMALLMVYALLVQRGLRTSIAARDPFSKLLAGGLSFILAWQVFIIVGGVTNLIPLTGLVTPFMSQGGSALLANWILIALLVRMSDAARKPPPQAIQDEGMTQVFQR
>NC_013595.1|WP_012886914.1|113624_115082_-|peptidoglycan-glycosyltransferase
MNSTLKRVALACLLMFGLLMLNVNYLQGVRADDLRADSRNVRNFYDRYEVERGRITAGDKVLAESVDTGSNTFRFERRYPEGKVYAPITGFFAPESERDMELAKNSLLNGTSADLLIRRSIDLFTAKKTKGANVDLTINPKAQEAAYKALGASGKKGALVAIEPKTGAILAMVSIPSYDPNPLSRANKAEVNKAYNKLADDKDQPLLNRAIERTYPPGSTFKVVTMAAYLESDDTLGPQSQVDAPQRLDLPNTTADLPNYGGAACGSGRVTLSFALERSCNTPFGKIAIDLGYDAVNDQARKFGIGGDALTIPMPVAASDFGPEEDKAALAQASIGQRSNQMTPLQMAMIAAGIANNGVVMKPYLVNKIADAEGGEIEGADPEEFTTAISEDTARKLQEMMVNVVNNGTAGAAKIPGVTVAGKTGTAETAEGRDPHAWFISFAPAEDPKVALALMVESGSAGDDASGGHTAAPIAKSVMEAVLGR
>NC_013595.1|WP_012886913.1|112218_113628_-|serine/threonine-protein-kinase
MTALLGGRYRPLGRIATGGMGEVWRAKDELLGREVAVKLLRRHVAADPAFRERFRREARIAAKLADPGIAQVFDYGEADGVAYLVMELVPGESLAGILARDGALSVEITLDVVYQTAKALRAAHGAGIIHRDIKPGNLLVTGAGVIKITDFGIARALEASSMTQTGTVLGTAQYVSPEQASGDPLTFATDVYSLGVVAYECLAGRPPFVAETQVAIALMHLGETPPPLPGSVPAAVRELVMACLSKDPERRPAGAGELAGRAYALRESLATAGAADLAMLTDPAGWRVEPAGEWPREVAPALASAPGPGSGPATGSGPAPVRTARIAPRRRGLGRKTVIVAVAAGCAAAVGLGTLVVHDLTERNGESKSEEPVVPLSPVTKTPTVRPSRTKPVTTRPPVSPTKPLRPSPTPSATVSTSVKPSPRPTTSPSPSPSPTTSTPTPTTPTATPSLTPSTTPGPGDTEPPNGET
>NC_013595.1|WP_012886912.1|110279_112136_-|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MTQPRRLGDRYELDGVVGRGGMAEVYRARDIRLDRIVAIKTLRADLARDHIFQARFRREAQSAASLNHPSIVAVYDTGEDVAGSAPVPYIVMEYVDGRTLRDLLRADRRLLPERAAELVDGILRALDYSHRGGIVHRDIKPANIMITNNGDVKVMDFGIARAMADSAATMTQTAQVIGTAQYLSPEQARGERVDARSDIYSTGCVLYELLTGQPPFTGDSPVAIAYQHVREDPIPPSQIDPEIPKWADAIVLKAMAKDPAHRYQSAGEMRADIQRAMSGIPMDAQTMALANNYGSATRTMQTPGPGGPATQRTTSVPAYEYGTEEGGRGERGRRRQQSSGNTAVKTAAWILVPLLVIGAFIGVGYMFLSSPGDSSAANKIKVPALTSRTEAAATKALTDLGLTVKTVEKFDEESEKGTVIETSPAAGTAVDKGAEVTLTISKGVEKAEVPNVVNMTTDEAKAALEEAGFVPSVRTKASSGPQDKVLETNPPAGKKAPKGSTVQIYVPKEAVEVPGVVNLTVGDAKRMLKEAGFKYKVVEQESDLPEGTVLSQAPEAGAKLQQGTTITLVVSSGQAPQPTEPPTTDPTQEPPITEEPEPDPTETEDPIFNEAPSDDLGG
>NC_013595.1|WP_012886922.1|124585_125245_-|GPP34-family-phosphoprotein
MTTIIAEEVLLLAYSEVEGKQLIGSSELDAALGGALLAELAIDGRIDLADKKVTVLDPTPLGDEELDAALARIVGEPKERKPDWWVYKLHSAKLRKRLLSRLAERGVLSEEPRKILGIFPSTRYPERDPRVEQGIRESVQSVLSGAVPDERAAVLIAVLHAAKIDRKAFPGASKERIKEITEGEWAGAAVAKTIAAINSAVMTAVIAGSIAASTAATSG
>NC_013595.1|WP_012886923.1|125355_125934_+|DM13-domain-containing-protein
MRIRRLLRHPAAWAVMTLGAVALGVALYLFQPWRLFTTVEVDEAVPVAAVTPRATPEAGGRTTATRPPDGRAKAAEGPRTLAAGTFVSHEHSTEGRARVLELADGSRVLRIEGLETSDGPDLRVWLSDQPVKEGRAGWFNLDDGKHLELGELKGNRGNANYAIPAGADLDSLRTATIWCKRFGVSFGAAALT
>NC_013595.1|WP_012886924.1|125949_126555_+|transcriptional-regulator
MSISAELHAIGRPLVEAQLAHPTVVGIAKGNLAEPVFRSWLEQDYLFLLDYVRVFSRLAWQAPDGHLGDLVDLAHATFHEELALHRSLSAEFGADLDGAKKGPACVAYTSFLLDSAADYADGLAALYPCMWGYSTLGRVLAENPPAEPRYRAWVDTYAHPGFAELTGRIAVMIDEAVPDLGRAGALFTEGMAHELAFWDVP
>NC_013595.1|WP_174435242.1|126838_127162_+|rhodanese-like-domain-containing-protein
MSVPEVEVQDVPDGAFLLDVRENDEWRAGHAPAAVHIPLGELQARVGEVPKDAPVYVVCRAGSRSAHAAAWLGHVGWDAINVGGGMQSWEVAGRPMVSESGQDPFVA
>NC_013595.1|WP_012886926.1|127337_128684_+|cytosine-permease
MTSDVIDAKHAEAPLTLDQAPPKTLGALDQGAFWANLGVSLLGFSFALFLINPLNDDNPLTFTAALVASLVGSLIGTAMVGLAAVPGAQTGQPAMVLLRGLFGARLSAVPTVLNIIQMIGWGAFELWVVAMGAQAIFGTSVPYAAWAIAAGVLTTALTIYPLGAIRLLRRFVTVGVVISIIWFAVVFLRDTPAQTGGSWDAFAPAVDFVIALSVSWVPVAADYARYSRSSRAAFGGVVGGYTIAQVACLAVGVYAVALAGHGAVSDQPTAVFAPFVAAPLGALFFGILVLRETDQSFANVYSTAMSLQNLMPRVDRRIFSVAIGVLTTGVALVVDVNSYGAFLGIIGAVFVPMLGVLAVDYFLLGHGRDWDTSENAPSRWLMVIPWVLGFATWWLLAAPSAVPWWAAIWNGVRQAVGFTPQPWMSAAVGAFLVAGLVTLGLGALRRRR
>NC_013595.1|WP_012886927.1|128740_129325_-|methylated-DNA--[protein]-cysteine-S-methyltransferase
MSSGDIDALLRVTSPDYIGKTHPDIAFGTLDGPVGRLILAVTNRGVVACSYEDENVVFERVSREVGSFIGPDPRRLDPVRRELDAYFSGRLRAFTITADLRLATSFARTVLQMMIAVPYGTVTTYREIAERIGRPRALRAVGNALGSNPVCVIVPCHRVVENEAVLGGYAGGATAKGRLLRVEGANGSRSPGGS
>NC_013595.1|WP_012886928.1|129399_131322_+|PAS-domain-S-box-protein
MRTKVPRSGWLTRHYGCVGDNRAASDDGIGRAVIAGAPNAIVAIDRDQAVLTWNPAAERLFGWSAGELLGRRVPLVPEELTAEHNAVLERVRTGGQVSLRTKRFRRDGSLIDVRVDTSALRSEAGVLLGYVSVYHLTQDDETAHDRVARRAQLVRRLTDVVADINAERELPAVLDRIAASLAELTGADAGGFVLIEGDRVRLVASHRLPGSLRDSTADLRTSLVGKLLRTGRTVMLETGDQARLDELIWSQLPGLHTIALGVAAVGGRPYGALYALFAKRKAGHVELELLELLAGHAGIAVANAMAYQEAVRQRAHERAVFDASADGIAVLDGAGRVIQWNPAATELTGFHAAEVIGGPPPFQLPEPGDKLTLQLPSGAWLDVLCAEIVETGEIVVDFRDITRAKELEEAKDLFLATTSHELRTPITVVRGFAGTLDSRWDNMTDAERRAAVHTIAERARSLGQLMDHLLLGSRAGAGELTLRIEGFDLGELLRAATLGLPVLSDLHRVEVSIPEDLPSVSGDALATDIMLGQLLENAFKYSPDGGLIRVEAWAAGERVIVVVDDEGVGIDPASRERVFERFVQGDSGDRRRFGGVGLGLYIVRSLAQAQGAEVSAHPRPGGGTRMRLALRIADTPGALT
>NC_013595.1|WP_052316833.1|131478_131934_+|ATP-binding-protein
MSASSVVLLPYAPSSVAVARQRLCSDLQEWGVYETAIDDAVLVVSELLSNALRHAHPLPSGQIRVAWRWTDGHVEVAVSDGGAATEPRAGRPTLSSLGGRGLGIVEYLAAKWGVRHDGEITTVWAVVTTVSTVSNGNGQVSIPEPILRECG
>NC_013595.1|WP_012886929.1|132012_132708_-|membrane-protein-insertase-YidC
MFDPVIEFTADLITALAQPLGSTALAIVLFTLGVRLLLLPLSVMQARGERVRARLAPEVQELRRRHGRDPERLHRELTALYAGEKASPLAGCLPGFAQMPFFMLMYQVFASSVIAGHANALLTHGLFGVPLGQQFAGAVAGFGLLSVPTLVFAGLFLLLLAVASVTSRRMRRTMGEQVQPELLRRVMPLLPFGTLLAAAVLPLAAGLYLLVTTAWAAGERAVLYRAAPAGG
>NC_013595.1|WP_012886930.1|132778_133045_-|hypothetical-protein
MSVLLALQTLSVWMFDGGGAVTATAVVGLGVLLLAWALRALPLTSEAGPRSALSRRDRARQTMFVRQRDPDAAGRSRPRAPSPGPAPA

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Crispr_ID: NC_013595_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_3

339026-339112

Orphan

Consensus_repeat	Method
CCGTCCGGGCTGTAGCCGGATCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_3

>merge|NC_013595|3|339026-339112|CRISPRCasFinder
CCGTCCGGGCTGTAGCCGGATCTCCGGGACCTCGCCCGGCCCGCGGTCGCGACCTTCCGGGACTCCGTCCGGGCTGCAGCCGGATCT

>NC_013595|3|3|339026-339112|CRISPRCasFinder
CCGTCCGGGCTGTAGCCGGATCT	CCGGGACCTCGCCCGGCCCGCGGTCGCGACCTTCCGGGACT
CCGTCCGGGCTGCAGCCGGATCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012887121.1\|332360_332690_-\|DUF3140-domain-containing-protein	unknown	unknown	gnl\|CDD\|371477
NC_013595.1\|WP_012887123.1\|334015_335020_-\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|224214
NC_013595.1\|WP_012887131.1\|340471_341623_+\|xylose-isomerase	unknown	unknown	gnl\|CDD\|237170
NC_013595.1\|WP_012887134.1\|343902_346110_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|377989
NC_013595.1\|WP_012887127.1\|337708_338218_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319918
NC_013595.1\|WP_012887138.1\|347596_347944_-\|DUF742-domain-containing-protein	unknown	unknown	gnl\|CDD\|283084
NC_013595.1\|WP_012887135.1\|346210_346600_+\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|367422
NC_013595.1\|WP_012887119.1\|330354_331044_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_013595.1\|WP_012887137.1\|347040_347616_-\|ATP/GTP-binding-protein	unknown	unknown	gnl\|CDD\|225138
NC_013595.1\|WP_012887132.1\|341619_342996_+\|xylulokinase	unknown	unknown	gnl\|CDD\|198375
NC_013595.1\|WP_012887122.1\|333007_333853_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187578
NC_013595.1\|WP_012887128.1\|338291_338741_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_013595.1\|WP_012887133.1\|343108_343759_+\|DUF998-domain-containing-protein	unknown	unknown	gnl\|CDD\|377627
NC_013595.1\|WP_012887125.1\|336190_336811_+\|cyclodeaminase/cyclohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377428
NC_013595.1\|WP_012887126.1\|336807_337647_+\|bifunctional-5,10-methylenetetrahydrofolate-dehydrogenase/5,10-methenyltetrahydrofolate-cyclohydrolase	unknown	unknown	gnl\|CDD\|223268
NC_013595.1\|WP_012887136.1\|346596_346968_+\|DUF742-domain-containing-protein	unknown	unknown	gnl\|CDD\|283084
NC_013595.1\|WP_012887139.1\|348008_348416_-\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|367422
NC_013595.1\|WP_012887130.1\|339217_340393_-\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NC_013595.1\|WP_012887124.1\|335214_336123_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NC_013595.1\|WP_012887120.1\|331191_332040_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|334634

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012887121.1\|332360_332690_-\|DUF3140-domain-containing-protein	gnl\|CDD\|371477	pfam11338, DUF3140, Protein of unknown function (DUF3140). Some members in this family of proteins are annotated as DNA binding proteins. No function is currently known.	5.14445e-46
NC_013595.1\|WP_012887123.1\|334015_335020_-\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|224214	COG1295, Rbn, Ribonuclease BN family enzyme [Replication, recombination, and repair].	9.20484e-64
NC_013595.1\|WP_012887131.1\|340471_341623_+\|xylose-isomerase	gnl\|CDD\|237170	PRK12677, PRK12677, xylose isomerase; Provisional.	0
NC_013595.1\|WP_012887134.1\|343902_346110_+\|sensor-histidine-kinase	gnl\|CDD\|377989	pfam08376, NIT, Nitrate and nitrite sensing. The nitrate- and nitrite sensing domain (NIT) is found in receptor components of signal transducing pathways in bacteria which control gene expression, cellular motility and enzyme activity in response to nitrate and nitrite concentrations. The NIT domain is predicted to be all alpha-helical in structure.	2.08806e-19
NC_013595.1\|WP_012887127.1\|337708_338218_-\|VOC-family-protein	gnl\|CDD\|319918	cd07255, VOC_BsCatE_like_N, N-terminal of Bacillus subtilis CatE like protein. Uncharacterized subfamily of VOC superfamily contains Bacillus subtilis CatE and similar proteins. CatE is proposed to function as Catechol-2,3-dioxygenase. VOC is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.05644e-19
NC_013595.1\|WP_012887138.1\|347596_347944_-\|DUF742-domain-containing-protein	gnl\|CDD\|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	2.51171e-24
NC_013595.1\|WP_012887135.1\|346210_346600_+\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|367422	pfam03259, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	1.73677e-21
NC_013595.1\|WP_012887119.1\|330354_331044_+\|transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.56259e-26
NC_013595.1\|WP_012887137.1\|347040_347616_-\|ATP/GTP-binding-protein	gnl\|CDD\|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	1.44301e-40
NC_013595.1\|WP_012887132.1\|341619_342996_+\|xylulokinase	gnl\|CDD\|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	3.0473e-166
NC_013595.1\|WP_012887122.1\|333007_333853_+\|NAD(P)H-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.91899e-63
NC_013595.1\|WP_012887128.1\|338291_338741_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	6.9161e-14
NC_013595.1\|WP_012887133.1\|343108_343759_+\|DUF998-domain-containing-protein	gnl\|CDD\|377627	pfam06197, DUF998, Protein of unknown function (DUF998). Family of conserved archaeal proteins.	3.07944e-10
NC_013595.1\|WP_012887125.1\|336190_336811_+\|cyclodeaminase/cyclohydrolase-family-protein	gnl\|CDD\|377428	pfam04961, FTCD_C, Formiminotransferase-cyclodeaminase. Members of this family are thought to be Formiminotransferase- cyclodeaminase enzymes EC:4.3.1.4. This domain is found in the C-terminus of the bifunctional animal members of the family.	7.15104e-55
NC_013595.1\|WP_012887126.1\|336807_337647_+\|bifunctional-5,10-methylenetetrahydrofolate-dehydrogenase/5,10-methenyltetrahydrofolate-cyclohydrolase	gnl\|CDD\|223268	COG0190, FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism].	1.24973e-107
NC_013595.1\|WP_012887136.1\|346596_346968_+\|DUF742-domain-containing-protein	gnl\|CDD\|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	2.16496e-28
NC_013595.1\|WP_012887139.1\|348008_348416_-\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|367422	pfam03259, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	8.99971e-24
NC_013595.1\|WP_012887130.1\|339217_340393_-\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.83103e-48
NC_013595.1\|WP_012887124.1\|335214_336123_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	2.19873e-15
NC_013595.1\|WP_012887120.1\|331191_332040_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|334634	pfam01674, Lipase_2, Lipase (class 2). This family consists of hypothetical C. elegans proteins and lipases. Lipases or triacylglycerol acylhydrolases hydrolyze ester bonds in triacylglycerol giving diacylglycerol, monoacylglycerol, glycerol and free fatty acids. Lipase EstA is a extracellular lipase from B. subtilis 168.	9.05443e-26

>NC_013595.1|WP_012887128.1|338291_338741_+|MarR-family-transcriptional-regulator
MTRWLDDDEQRAWRAFLTASQLVQEELDRQLQRDSGMPHAYYAVLVKLSEAPDRMLRMSELAAEVNSSQSRLSHAVARLEDRGWVRRERCAADRRVSWAVLTDEGFAVLAAAAPGHVEAVRQCFFELLDPEQLHRLTEICTVLLRKAAP
>NC_013595.1|WP_012887127.1|337708_338218_-|VOC-family-protein
MPVQRLNHAVLYVRDVERSVAFYEEALGFRVVMGMRGAAFLQASGSSNDHDLGLFELGSQAGASGAGRSTVGLYHLAWEVDTLAELERIAVKLSEMNALVGASDHSTTKALYAKDPDGLEFEVSWLVPADLLTEDVLNGRSGIKPLDLAREKERYGAQTRGGLGVSIPA
>NC_013595.1|WP_012887126.1|336807_337647_+|bifunctional-5,10-methylenetetrahydrofolate-dehydrogenase/5,10-methenyltetrahydrofolate-cyclohydrolase
MSARPLSGRDLAAAIRTDAAERAAELAAAGRPAKLAVVTATADESSAWYVRSIVTAAGKAGIACEVVDLGPEAPVAEIRERLESLSADDQVSGIILQTPLPGGAKLEDLASAIVPAKDVDGANPLSLGRLAAGLPAFAPATAEAVVRILEHHGVELAGRHAVVVGRSTVVGKPAAHLLLDRHATVTVCHSRTADLPAVTSAGDILVAAVGRAGLITAEHVKPGAVVVDVGTNPTEDGGLVGDVAPAAAERAGALTPVPGGVGPVTTALLLQHTVRAARE
>NC_013595.1|WP_012887125.1|336190_336811_+|cyclodeaminase/cyclohydrolase-family-protein
MRDQTISDFLERLAGRVPAPGGGASAALHAAQAAALLGMVARYSDGPGYAAHEQVISRILAETDALRDRALQLAEDDAAAFTAVTDSYRMPKATDEEKAARSAAIAGALAAAAEPPAQTIAAARRLVELAEELLPVGNRNVITDVAAAAEAARAAATTARVNVEVNLGGIKDEEVRAGLAGRAAGVDEIAAGAERVTAAVREEISR
>NC_013595.1|WP_012887124.1|335214_336123_+|DMT-family-transporter
MEQIIAPETRVDRRALLAAGITVVLWASAFVAIRSAAQYFSPGALALGRLLAGSVVLGVIWLARREGLPPRAAWPGILGSGLLWFGLYMVVLNWGEQEVDAGTAAMVVNVGPMLIALLGGWLLREGFPPRLLAGMAVSFAGAVVVGISMSDGGRASIVGVLLCLLAAVTYAGGVVCQKPALKHASALQVTTFGCFVGTAACLPFAGPLVTEIAAAPLPATLNVVYLGVFPTALAFTTWAYALARTTAGKMGATTYVVPALVVLMAWAVLGEVPGWLTLAGGLLCLAGVAVSRGGARRASPVT
>NC_013595.1|WP_012887123.1|334015_335020_-|YihY/virulence-factor-BrkB-family-protein
MSQHDIERPAGDGPPAGGPDLGPESETAPGSPAELPKRSWWDVLKRTVKEFQEDNLTDWAAALTYYAVLSIFPALLAVISVLGLFGQSATQSLVDNLGALAPGPARQTIDTVLQALQSSQRAAGIAAIIGIAVALWSASSYVGAFMRAANVMYEMPEGRPVWKTLPLRLGITAVLVILMAVGSVAVVFTGGLAEQAGKVLGVGETGLAVWGVVKWPILVIIVALVLALLYWAAPNVQHPGFRWITPGSMIAVVLWIAASAAFGFYVANFGSYSKTYAALAGVVVFLIWLWITNIAVLLGVEFDAELARERAIEAGQPAGEEPYAEPRDTRKFDE
>NC_013595.1|WP_012887122.1|333007_333853_+|NAD(P)H-binding-protein
MILVTGATGNVGRQVVSQLQDAGVAVRALVRDPSSAGLPEKVDVVRGDLSAPDTLEAALDGVESVFLVWPFLTADGAPAVLDAVGRHARRIVYLSSAGVREDVERQGDPINQFHADVERLIERSGLEWTFLRAGGFAANALAWAPEIRDGGVVRAPFGAATRSLIHERDIAAVAVRVLTGDGHGGAKHHLTGPELLSTVEQVRAVGEAAGRPARFEEIPAEEARRQMLDSGWPASVVEGIFDAHEGMVTEPERITSTVEEITGVPARTFRQWAADHAGDFR
>NC_013595.1|WP_012887121.1|332360_332690_-|DUF3140-domain-containing-protein
MTEDRERIATDFHQAVNMTAGELESWLDTRESKAVGDKSGRGESIGHESGRRIMGILRKGADDLSEEDYAHMREVAGYVRRHLAQRPSGDVHDTPWRYSLMNWGHDPLK
>NC_013595.1|WP_012887120.1|331191_332040_-|alpha/beta-fold-hydrolase
MRSLRLRRLISIFIGTALVTTALTGTAGAETSPDGANDWNCRPSFFHPHPVVLVHGTFENMAFNWSKLSPVLKKNGYCVFALNYGGVPDAPVQGTGDIAQSAGQLSAFVDRVLQATGAPEVDIVGHSQGGMMPRYYAKFLGGAAKVRKLVGIVPSNHGTTASGLVTLGRLLGLLDPVIRACPACGQQLVDAEFLGALNSGGETLPGVEHTVIATRYDEVVTPYTSSFLNGSGVKNILLQDKCPGDTNAHLGVNFDPVVHRIVLNELGFLTAYWPVDCSDPLG
>NC_013595.1|WP_012887119.1|330354_331044_+|transcriptional-regulator
MEQRTYNQYCATARTLDLVGERWTLLLVRELLTGPKRFGDLQHSLRGLGTGLLAARMKHLEREGLVHKVTLPPPARTAAYALTRAGEELGPAVLALARWGLKWAMDEPREQETFHPGWAVLGLRACFDAEAATGLHALYEFRVEEEIFHARIDDGTIETVHGPAQHPDVTITIGGEVFRDLAAGRSTLAEAINNGAASASGDQQALRRLHQLFRLPRPQTRSAAQAPAS
>NC_013595.1|WP_012887130.1|339217_340393_-|ROK-family-transcriptional-regulator
MTQAVRHDSMRARNLGVVLGEVRRSGPITRAALAEITGLTKTTVSKMVGDLLGAGMVTEAGALRDGERGRPGTAVSLSGHRVAALGLEINVDYLSACVVDLTLSVRLRRTQAVDNRAASPVETLAHLQELAHRAVDEARSEGLAIAGSTLAVPGPVDGGLLHAAPNLGWHDVRVGDLLDFPVAVENEANLAALGELWFGSGPSDFLHVSGEIGVGAGLVVGGALFRGARGLAGELGHVIVSPDGPTCRCGGRGCLEQYAGQEALLRAAGLDGVPELVERLQAGTPGALRACERAGQALGVALTSAVHLMDPGTVVLGGIFAPLFPWIHGPARETMTARLARMRHAVPELTVSRLGGDAASLGAAGQVIHRIIADPGAHLAATTARPAPGPH
>NC_013595.1|WP_012887131.1|340471_341623_+|xylose-isomerase
MSDYTPKPEDRFTFGLWTVGWQARDQFGDASRAPLDPVESVHRLAELGAYGVTFHDDDLLAVEPDRDKAVERFKKALAETGLKVPMATTNLFTHPVFKDGGFTSNDRDVRRYALRKVMRNVDLAAELGATTYVCWGGREGAESGAAKDIRAALSRYKEGMDLLTSYVIDRGYDIRFAIEPKPNEPRGDILLPTVGHALAFINELEHSERVGLNPEVGHEEMAGLNFAHGIAQALWHGKLFHIDLNGQHGPRFDQDLVFGHGDVKNSFFLVDLLENGGYDGPRHFDYKPLRTEDAEDVWVSAAANMRTYLILKEKVKAFHADPEVVEARAASRVAELSEPTLAPGETLEDLHRDDFDVDRAAARGFHFSRLNQLALEHLLGVRG
>NC_013595.1|WP_012887132.1|341619_342996_+|xylulokinase
MTLVAGVDSSTQSCKVVIRDAETGALVRQGRAAHPDGTEVDPAAWWTALQEAIARAGGLDGVAAMSVGAQQHGMVCLDESGAVVRDALLWNDTRSAGAARDLVEELGGPLKWAEAVGSVPVASFTVTKLRWLAEHEPGSARRTARVCLPHDWLTWRLGGEFVTDRGDASGTGYWSPATGSYRTDILAAAFGAVPGLPQVLGPRDQAGELSVPGGRGPVRLAPGTGDNMAAALGVGALPGDVVVSLGTSGTAFAVADVPSADPSGAVAGFADATGRFLPLVCTLNAARVLDAAARLLGVDLDRLGRLALDAPAGAGGLVCVPYLEGERTPNLPDATGSLHGLTLGTSTPAHLARAAVEGMLCHMADAFDALGLDPARVLLIGGGARSEAVRRIAPAVFGRPVVVPEPGEYVADGAARQAAWLLGGGAEPPVWETGGTERFEADATPDVRARYAEARDGR
>NC_013595.1|WP_012887133.1|343108_343759_+|DUF998-domain-containing-protein
MLALKRLYPLVACAGIVIAAVATVIGQIDPDPYLDPLNLTISEYAALDRGGATEFAMATLGVASFALVAGLRAAMAPIGAAAERLMLAWSAALVVIAIVPTTAPGLAMDLTAQVHRYVSIAAFVAMPVAGALMVARLREDERWRAVARPVEWLALAGGFGLLAITYVALPGDRVLIGLVERVLLGAEVALIGVLAVRLAQLTWVRSAARASRAALG
>NC_013595.1|WP_012887134.1|343902_346110_+|sensor-histidine-kinase
MASSRSIRFKISVLVAIPLTSLVALWGFAATVTVGDSMSLLTVATMYDSFGGPGDDLSNALQREHLLSSEYLAGRSEADRATLAGQRTVTDQARARFRRATVADPAQSAMTPEMRVRFDELMARVNALDTLRSKIDNNRIAPVTLANEFALVPDALHRLFNSMSLNNDLPLYRQSRGLTVIIYAKDFLSRERALAAGSLALGRRMTSSELRLFTQLSTKRIFLMEQGLPELEQGLRKPFTDLAASRLYSRFTDLEERLLSGATVSPTDWRAATDDLEAAYQRSVTATGIALYDRATPSAVETFARAGIAGVLGLVAVVASLLVSYRVGRGLTRELADLRQAATDLAETRLPRVMGKLRRGEKVDVEAEAPPLEPLGSTAEIHDVAAAFDSVQHRAVDSAVEQARLREAVAQSFRNLARRSQSLLQRQLKLLDGMQKQAEDPDALENLFRLDHLTTRMRRHAEGLVILSGGAAGRKWRSSVLMEDVLRGAAAQVEDYARVRIYPMPGTTLVGSAVADMMHLFAEIIENATVFSPPGGEVSIRGELVGRGFTIEIEDRGLGLTAEKRAAINERLASPPEFDPAETDRLGFAVVGLLAARYGVGVTLRTSPYGGTGVVILLPESLLGDPEPVDPEPVLREITTSVEPVLREIAKPVEPVVPVPADLWKTPLRRGNGGLPRRVRQANISPQLRQESAPVAEAEERSPEEARALLNSFQAGWRRGRSAGEDSDDDSGMER
>NC_013595.1|WP_012887135.1|346210_346600_+|roadblock/LC7-domain-containing-protein
MPGELYWLLDDFVTSVADVSHALILSNDGLMVASSRGLSKEDADHLSAVASGFQSLAKGTSLQFGGGAVRQTMVEMDSAFLFVTSAGQGSCLSVMTTGAADVGLIAYEMARLVTRVGQHLATGPRVAGQ
>NC_013595.1|WP_012887136.1|346596_346968_+|DUF742-domain-containing-protein
MSDDVEWVDEEAGPVVRPYALTGGRTSTSSAAFDLLSMVVATGSAVSASSHLGSEHRRLLGLMRRTRPIVEIASDVGLPIGVIRVLLGDLLDQGLILVRSPLPAATSPAESLLKEVISGLRAL
>NC_013595.1|WP_012887137.1|347040_347616_-|ATP/GTP-binding-protein
MDFGPSDEPVALKILIAGGFGVGKTTLVGAISEIRPLRTEEVLSDRGIGIDDVEGVEGKTTTTVAMDFGRITIREGLVVYLFGTPGQERFWFMWDELSYGALGAVVLADTRRLTDCFPSIDYFEQRGTPFIVAVNCFDGADRYEAEDVRVALDLDPDVPVLLCDVRRRASAKNVLVTLVEHSLKVLTASQH
>NC_013595.1|WP_012887138.1|347596_347944_-|DUF742-domain-containing-protein
MTQWMDEEAGPIVRPYALIGGRTRSSGDALDLIAMVTATGAVASGGFVPGPEQERILSLVTTATSVADVASELDLPLGVVRVLLGDLQDHQLISIGRASASERILKEVINGLRAL
>NC_013595.1|WP_012887139.1|348008_348416_-|roadblock/LC7-domain-containing-protein
MTGKVTNTGELNWLLDDLTTRVGAVRQAVILSTDGLAVGFSKGLSREDAEHLSAVAAGFQSLARGAGRHFGGGEVRQTIVEMESAFLFVTAAGQGTCLAVLSSSDADVGHIAYEMAMLVKRVGQHISTLPRQGLS

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Crispr_ID: NC_013595_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_4

382130-382215

Orphan

Consensus_repeat	Method
GACCTCCCGCGCCCGCGCGGAAGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_4

>merge|NC_013595|4|382130-382215|CRISPRCasFinder
GACCTCCCGCGCCCGCGCGGAAGGGGCGAGCCCGACGGTCCAGAAGTCGGCGTCGCGCTCCGACCTCCCGCGCCCGCGCGGAAGGG

>NC_013595|4|4|382130-382215|CRISPRCasFinder
GACCTCCCGCGCCCGCGCGGAAGGG	GCGAGCCCGACGGTCCAGAAGTCGGCGTCGCGCTCC
GACCTCCCGCGCCCGCGCGGAAGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012887172.1\|388424_390830_+\|ECF-subfamily-RNA-polymerase-sigma-24-subunit	unknown	unknown	gnl\|CDD\|274357
NC_013595.1\|WP_012887171.1\|387701_388238_-\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
NC_013595.1\|WP_012887160.1\|375036_376326_-\|GTP-cyclohydrolase-IIa	unknown	unknown	gnl\|CDD\|179391
NC_013595.1\|WP_012887156.1\|371433_372099_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|226596
NC_013595.1\|WP_012887174.1\|392554_394435_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_013595.1\|WP_012887162.1\|378181_379219_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012887168.1\|385252_386275_-\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|236406
NC_013595.1\|WP_012887173.1\|391260_392442_+\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350235
NC_013595.1\|WP_148269434.1\|372107_372761_-\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NC_013595.1\|WP_012887159.1\|373967_374906_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|183067
NC_013595.1\|WP_012887165.1\|382316_383243_-\|glycerophosphoryl-diester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176510
NC_013595.1\|WP_012887158.1\|372844_373906_+\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|179559
NC_013595.1\|WP_012887163.1\|379324_380557_-\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|234856
NC_013595.1\|WP_012887169.1\|386442_387168_+\|VTT-domain-containing-protein	unknown	unknown	gnl\|CDD\|182775
NC_013595.1\|WP_012887170.1\|387245_387653_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012887155.1\|369572_371414_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373094
NC_013595.1\|WP_012887161.1\|376551_377820_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NC_013595.1\|WP_012887166.1\|383330_384614_-\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NC_013595.1\|WP_012887154.1\|368423_369512_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340825
NC_013595.1\|WP_012887167.1\|384740_385163_-\|DUF3151-domain-containing-protein	unknown	unknown	gnl\|CDD\|378646

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012887172.1\|388424_390830_+\|ECF-subfamily-RNA-polymerase-sigma-24-subunit	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.31092e-13
NC_013595.1\|WP_012887171.1\|387701_388238_-\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	7.2373e-62
NC_013595.1\|WP_012887160.1\|375036_376326_-\|GTP-cyclohydrolase-IIa	gnl\|CDD\|179391	PRK02240, PRK02240, GTP cyclohydrolase IIa.	0.00703414
NC_013595.1\|WP_012887156.1\|371433_372099_+\|NUDIX-domain-containing-protein	gnl\|CDD\|226596	COG4111, COG4111, Uncharacterized conserved protein [General function prediction only].	1.33427e-17
NC_013595.1\|WP_012887174.1\|392554_394435_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	9.54378e-97
NC_013595.1\|WP_012887163.1\|379324_380557_-\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NC_013595.1\|WP_012887173.1\|391260_392442_+\|NYN-domain-containing-protein	gnl\|CDD\|350235	cd10911, PIN_LabA, PIN domain of Synechococcus elongatus LabA (low-amplitude and bright) and related proteins. This subfamily contains Synechococcus elongatus PCC 7942 LabA which participates in cyanobacterial circadian timing, it is required for negative feedback regulation of the autokinase/autophosphatase KaiC, a central component of the circadian clock system, and appears to be necessary for KaiC-dependent repression of gene expression. This subfamily belongs to the LabA-like domain family which includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Also included in the LabA-like domain family are human ZNF451, uncharacterized Bacillus subtilis YqxD, uncharacterized Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously Pseudomonas putida S16 NicB , which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	7.69612e-14
NC_013595.1\|WP_148269434.1\|372107_372761_-\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	1.4643e-21
NC_013595.1\|WP_012887159.1\|373967_374906_-\|EamA-family-transporter	gnl\|CDD\|183067	PRK11272, PRK11272, putative DMT superfamily transporter inner membrane protein; Provisional.	2.29872e-63
NC_013595.1\|WP_012887165.1\|382316_383243_-\|glycerophosphoryl-diester-phosphodiesterase	gnl\|CDD\|176510	cd08567, GDPD_SpGDE_like, Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of uncharacterized bacterial glycerophosphodiester phosphodiesterases (GP-GDE, EC 3.1.4.46) and similar proteins. The prototype of this CD is a putative GP-GDE from Silicibacter pomeroyi (SpGDE). It shows high sequence similarity to Escherichia coli GP-GDE, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	6.78762e-91
NC_013595.1\|WP_012887158.1\|372844_373906_+\|histidinol-phosphate-transaminase	gnl\|CDD\|179559	PRK03321, PRK03321, putative aminotransferase; Provisional.	0
NC_013595.1\|WP_012887154.1\|368423_369512_+\|glycosyltransferase	gnl\|CDD\|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	2.4159e-32
NC_013595.1\|WP_012887169.1\|386442_387168_+\|VTT-domain-containing-protein	gnl\|CDD\|182775	PRK10847, PRK10847, DedA family protein.	7.08669e-35
NC_013595.1\|WP_012887155.1\|369572_371414_+\|hypothetical-protein	gnl\|CDD\|373094	pfam14488, DUF4434, Domain of unknown function (DUF4434).	7.63064e-05
NC_013595.1\|WP_012887161.1\|376551_377820_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	2.26647e-179
NC_013595.1\|WP_012887166.1\|383330_384614_-\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NC_013595.1\|WP_012887168.1\|385252_386275_-\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|236406	PRK09197, PRK09197, fructose-bisphosphate aldolase; Provisional.	0
NC_013595.1\|WP_012887167.1\|384740_385163_-\|DUF3151-domain-containing-protein	gnl\|CDD\|378646	pfam11349, DUF3151, Protein of unknown function (DUF3151). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.06822e-69

>NC_013595.1|WP_012887163.1|379324_380557_-|phosphoribosylamine--glycine-ligase
MRVLVIGSGGREHALCRSLAADPQVTEVHCAPGNAGVAQVATLHPVTPTDPAAVSRLALELGADLVVVGPEAPLVAGVADAVREAGIPCFGPSREAARIEGSKAFAKDVMVAAGVPTARSRTCVTPEEAAAALDEFGTPYVVKDDGLAAGKGVVVTDDRDEALGHAAACGRVVIEEFLDGPEVSLFALCDGSTAVPLQPAQDHKRAYDGDKGPNTGGMGAYTPLPWAPGDLTDRVMAETVIPTVTELARRGTPYTGVLFVGLALTAEGPKVIEFNARFGDPETQVVLDRLETPLAGLLLACADGTLGGFGPLSYRDGAAVTVVIAAENYPADPVKGDVIEGLSDTVENAYVLHSGTALDGDRVVSNGGRVLSVVGTGPDVAAARAAAYEAVGRIRMRGSHHRTDIAGHSA
>NC_013595.1|WP_012887162.1|378181_379219_-|hypothetical-protein
MAFDQTASPERIGDTGVLRWPGTWRVYVATRSEEIRADAERALTMRDGAGQLVSVGDGIGRHLERAEVYARSRHGLRRWLTGQAIEGAWSNVNSATVMLYGVLPTAELCGRGPEVAAIGRAYLPGDDPRLTHLQTRLAAGDLGEDDRPLMQSVLRAAYTAQAMETGRVRSFRNLLLGGVVMLSLIVLGVVTIGAIWPDVIPMCGNQSVVQAQGLMPAQICPTGSLRPSRGDVPLVALIGMLGAALATAASLSTRSELSTRYSLAVVQNMLKAPAGVATSVLGLLILNSGFVPGFAGLGSQPAILVWAMAFGYGQQVVTRFVDQRADNLLLAASPLTPAGRGTRAA
>NC_013595.1|WP_012887161.1|376551_377820_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MVRYRVRGGNPLRGTAFIQGAKNAVLPMIGAALLAAKGRTVLRNVPIIEDVRRAVELAEAIGAKVELHEAERTLVIDASRLKSPVLPAEIARRFRGSVLFVPALLHRLGEAIIEGVGGCNLGSRNLDFHYLGYKRLGAIVDEGDSVIHVKTAGFTGATLYLDTPSHTGTENLIMAAALGRGTTVIENAALEPEVLDVIEMLTRMGARISGGGTGFITVEGVEELQAVEHTVMPDRLDAGVFAMAAAITGGEVNLVGADLDHLGVVRYKLEQMGVEFSDHGAVLHVRRDRPLRPINVITDTYPGFATDLQSPIMTVACLADGASYIHERIFDGRFALASELNKMGADIEVKENSAVVRGATPLTGTEVTAHDLRSGIALVLAGLAAEGETVIESGYLIDRGHSYLAERMQALGADVRREISSS
>NC_013595.1|WP_012887160.1|375036_376326_-|GTP-cyclohydrolase-IIa
MTPDLTIGVVGPHDLVERVMLMGHAAAPLPCRLVAAAYRDEQEAADKVTRLGAGVDACLFASPVPYDLARRSGVLTMPATYVQLGGAALIAALARAALDERIDPRRVSVDVLSRADVEEAYTDLSLPVADVHSRDEPGATGTIAAFHERLARQGNTSGALTCLPAVADRLQTAGVPVVRIRPTSAAVRTALHTAALLGAHHRLEESQLTVVLVEVPTLREPVRRAAPRYWRDELRLSLHRLLVQEANRINASVTSIDDHSYMVTATRGSVAMATEGFRVLPFAARVRDELGLAVEVGVGMGRTAHDAESHARAALARTQAGKQAQGFAVDREGRALIPAPRMPPQGGGPLKPKGVEVLARLAAKLEGGDTVVDAEGAGKMLGVTPRTARRLLRTLVDEGLAWPLPPNRTPQPGRPRQLYRLIVEKLGSR
>NC_013595.1|WP_012887159.1|373967_374906_-|EamA-family-transporter
MGHDTTDSRGSLLVWGALAIVYVVWGSTYLAIRIAIETVPPLLSGAMRFSTAALILGTAVLLLRGWRAFRMTWKELGGAALVGLLLLNAGNGLVAVAEQHISSGLAALLVASVPLWLVIFRIVARDMPQVLTLAGVLIGFGGVAVLSLTGGGSAADSTGIVIILLASMSWSAGSFLSARIPMPANPFVASTVEMAAGGIGLALTSTVMGEHLDLGAVSGRSWAALAYLVVMGSLVGFTAYVWLLGAAPISLVSTYAYVNPVVAVVLGALVLSEPVTTSMVAAGLVIVLGVALVVSTERRRNAPTEEKEPASV
>NC_013595.1|WP_012887158.1|372844_373906_+|histidinol-phosphate-transaminase
MPRFRAILDTMPPYKAGKAVVSADGRSYKLSSNESPYGPLPSVVEAIAKAASEIHRYPDPAATGLTDALAERYGVPPEHVALGAGSVTVAQQLFETVSEPGAEVIYAWRSFEAYPLLADLAGATSVRVPLLGETHHLDAMAEAITPQTRMIFVCNPNNPTGTVVHAAELAAFLDRVPENVLVVLDEAYREYVRDADVTDGLTVYRDRPNVAVLRTFSKAYGLAGLRVGYLIADEPVAAAVRKTIVPFAVNHLAQAAAVASLAAEAELLERVDTVVKERTRVREALIAQGWTVPITEANFVWLRLGERTTAFAEACAADGVAVRPFAGEGARISIGSPEANDTFLAAAAAFRAA
>NC_013595.1|WP_148269434.1|372107_372761_-|Uma2-family-endonuclease
MSIAPLTETERPDTEPDTGTAGAESPKLEPVPDWIIPSSDGFTAEDLDRLRGIPSHTELIDGTLVFVSPQTRFHSLVMFLLERELRHTAPAELRVRREMTVTLGERQRPEPDLIVVRADGDLGMKQTTYQPADVVLAVEVVSAESEIRDRERKPQLYAAAGIAHFWRIENVEGHPTVYVYELDPATKTYALMGIQHDRLKLTVPFDVDIDLAEIDDL
>NC_013595.1|WP_012887156.1|371433_372099_+|NUDIX-domain-containing-protein
MVPRIPVSVDLVVLTVRCQALSALVWRRDKSPYEGRWALSGGFIQLDEDLPAAAARVLAERAGLPGAPVHLEQLQTYGYPDRDPRQRVLSVAYLGLAPDLPASTEAHMSWQPVSSLREMAFDHRRIMVDGIERARGKLEYTPLGAAFCPPEFTVADLRRVYEIVWGRTLDPRNFHRKVTKAEGFLVPTGRTTTRDGGRPAKLYRRGPALLLHPPMLRSLKE
>NC_013595.1|WP_012887155.1|369572_371414_+|hypothetical-protein
MRWLTAFLGVAILAVVAAIVLVLPEGADAPASDRTPVASSPSTTSSAALTPEASAFTDPCGTFDTKVASPYAVTGYWLIPTTDHCTWRRQFGAIHEVGGDTVIRIGWGLQARRVDEDGRIMDNAGEEIDPRYEPCVEDGLPCVAAAEKDLQAANPGNRVSWTFVYRTDEAFGPGLFRCPEFERTVTVGKTVFYRIIAPDDGSDDPGCANIKNSGRGYHVILIAGAEQDNDSLTELLDLGDQFGVRVFPALPLAPRDPAQATRAYKDGTDTLTTLTRRILQDYGARFQGRESLGGFYQPFELQMREMSYTGKDPDDDHATLKVYASQHQIVEQEMPGKPILVSPYIDARKRLKFSASPKQVAKGFEAMVRTGVGIIAPQDSRGTGKVGLFWPDQRDEQVDERLRPVVGETTNGTAYHGSTRDYYREMAAARDRMVAQGYNVQLWANVEAFEPSAEEPCAARTGTRGRTDKKRLDTAVTQVGRYVSKVVSYMWSDFFTCGSPSLAEDIARDADRPIPVDAVRKERDIQDGMEIRGYNMPMGSKVTITWDGQEAPKVVDVAGVDLSEPLPDLPTGMRTAWIPFDWTQVPDDTWVKIEVAAADGRAAAEALHVRMNA
>NC_013595.1|WP_012887154.1|368423_369512_+|glycosyltransferase
MHVLVMTVVHHPEDARILHRQIRALVDAGHEVTYAAPYTARGVMARSWVNGVDLPRAAERKRLSAVRAARKVFKRMRDQVDLVVIHDPELLLAVVGVRKRPPVVWDVHEDTPATLSLKPWLPAFLRPPVRFMARMLEGTAERHLHLLLAETAYAGRFHRAHLVVPNETWVPDDVTPPGDDRIVYLGWLSEARGVRDAIEVARLLRPYRVAVELIGYADPQSRPTLNEAVAEGVLEWRDFMPNDEALKRLDGALAGLSLLHDEPNYRHSMPTKIVEYMAHGIPVITTPSPRAVELVERYNSGLVVPWEDPKAVAQAVLSLRDDVRERHAQGARGYAAARANHHWPNSARRFVSQLEAWAGVKS
>NC_013595.1|WP_012887165.1|382316_383243_-|glycerophosphoryl-diester-phosphodiesterase
MHAEIHGHRGARGLRPENTLPGFACALELGVDALELDVALTADRRLVLTHDLTVSAVTSADTRPAFYGDPLFPYVGRPVGELTLAQLRTLDCGVRLPRHPEDRFVRTQAPVPDTRMPTLGAVLGLVDAYGADGVRLHVELKSDPTRPELSADPREFTEMVVAELDRHHRLGGAAILSFDWRILEIARSLAPATRRYALIERATMDSVWLNGLRLEDFDGDLPAAAVAAGGTTLSPEHVLVDQELARRAEKAELPLVPWTVNEPDRAAELLDLGVAGLVTDYPDRMRALWADRGMPVPAPVTPVRRADR
>NC_013595.1|WP_012887166.1|383330_384614_-|adenylosuccinate-synthase
MPAVVLVGAQWGDEGKGKATDLLGDQVDYVVRYQGGNNAGHTVVIGDQKYALHLLPTGVLSPNVIPVIGNGVVIDPGVLLSEIDGLEARGVSSERLLISANAHLIMPHHKALDKVTERYLGKAKIGTTGRGIGPAYGDKIYRMGVRVQDLLDPGILQKKIEVALGEKNQILTKIYNRRAIDATKVLEEYLGYAERLKPHIADTSLILNKALDEDKVVLLEGGQGNLLDIDHGTYPFVTSSSPTSGGACSGSGIPPTRLTRVIGILKAYTTRVGSGPFPTELEDEMGEWLRTTGGEYGVTTGRNRRCGWFDAVIARYASRINGVTDFFLTKLDVLSGLERIPVCVAYEVDGVRYDEIPMTQTDFHHAKPVYEEFPGWQEDITGAKSFEDLPANAQAYVKALEQMSGARISAVGVGPGRTETIQIHSLV
>NC_013595.1|WP_012887167.1|384740_385163_-|DUF3151-domain-containing-protein
MTESHENLLAGPPPTRLPDLPEAREALESGAQASDVAARFPAYPGAWAALADEYFAGGHAVTSYAFARTGYHRGLDQLRRAGWKGHGPIPWDHEPNRGFLRCLHALARAAQAIGEKEEAERCFQFLKDSSSEAAEELTGR
>NC_013595.1|WP_012887168.1|385252_386275_-|class-II-fructose-bisphosphate-aldolase
MPIATPEVYAEMLDRAKANEFAYPAINVTSSQTLNAALRGFAEAESDGIVQVSTGGAEFLSGGTVKDMVTGATALAEYARVVAAKYPVTIALHTDHCPKDKLDTFVRPLVDISLERVARGQDPLFQSHMWDGSAVPLEENLEIAQELLEKTARARIILEVEIGVVGGEEDGVVGEMNEKLYTTTEDALATAEALGLGERGRYLLAATFGNVHGVYKPGHVKLRPSVLKEIQEAVGAKYGKEKPFDLVFHGGSGSLLEEIHEAISYGVVKMNIDTDTQYAFTRPIAEHMFKNYDGVLKVDGDVGNKKAYDPRSYGKAAETSMAARVVEACRHLKSAGTKIS
>NC_013595.1|WP_012887169.1|386442_387168_+|VTT-domain-containing-protein
MDLLHDLLDPKWWLGLLGPFATIGVLGIIFAETGLLLGFFLPGDSLLVAAGVFSTPEAAAAIEGLEPLSFPLLLVLAPICAIAGAQLGHHLGATYGRRMFDRPDSKLFKKEYVDKAEHYFQKFGPSKAVVLARFIPIVRTFLNPVAGMLGMDRKRFFLWNCVGAVIWTDGLLVFGRLVGSAVPDIDRYILPGALVIILLSVIPIIREIMKNRKGGGPGVPLPQGKHHRTTPTGPPNGDSPR
>NC_013595.1|WP_012887170.1|387245_387653_+|hypothetical-protein
MGIARLALAGLAVLVAVALIVVGAFSLVGALNPDPGPAAPSTPAAAPSVPSATPEQIPTVRVQCLQEHCPKVFLKVAGGDVLLDREMARDEQAQSFDAKVDVVLADSAAVRVEVNGEVRPPGKAGERQEFTASRD
>NC_013595.1|WP_012887171.1|387701_388238_-|orotate-phosphoribosyltransferase
MSDRESLLAEIKDKGVVHGRVVLSSGKEADFYVDLRRVTLDGQAAPLVGRVMLDLTEDLDYDAVGGLTLGADPVATAMLHAAAARGRALDAFVVRKAQKAHGMQRRIEGPDVAGRRVLAVEDTSTTGGSPLTAVEALREAGAEVVAVATIVDRGAASAIAEAGLPYRTAYSLQDLGLA
>NC_013595.1|WP_012887172.1|388424_390830_+|ECF-subfamily-RNA-polymerase-sigma-24-subunit
MSVKTVQGDAELLTETRHGNAVAYGGLRERHAPAARILARLLVDGPAEAEEAVAETFAGILHLLRRGGGPREAFRPYLLTALRRTVHDRSQGRGGWVTDGEASGPWVPFVDPALSGLERSPVARAFLSLPERWRLVLWHAGVEGAGPAEIAPLLGMPAGGVTALVHVAREGWRQACLRAHLAGTPRQECRPVLGMMGVYVRGGLARRESRPLDEHMDGCAECHDVFLELADVNQGLRVIVGPLVAGPALPGYLAALDRAGGTGAAGPFGRWRRAPASRRAVAAGAAVGAVSLAAALAAVLVPVSAQGPQVPSAAAVPEPVAGAPTPAPAPVPGPQDPPSPPLPPSPEPSPGKAEKPRRPDGPGAVAPPAQRGAVPAPRLIARIDALGALVRSEAGIVAVRLRNVGAGGSGELVADVGLPDGVTVLAAARRGRAVAAIRPVGTVDGWACRAGSGGARCFRRPLAAGRATAIFLRVAVSPTAAEGSAPSVRISAAGIGMTARARTGVRTAGAPARFATDGQVSTSAIGNTLMVCASVAPACRAARSRRGDRRDNDLWEMGPLDQDRDPSTRSSSAARLALPRRSKVVWAGLYWSAGAPADGRIKFKAPGDGGYTRVRAERVTERELPAGVGYQAFADVTRLMGRLPGTYWAADASLRPGVSRHAGWSLVVIAADSRQPYSQAVVVDTATVVDREHGPAWIPLDGLTPTAAPVRVDLVTWEGDAGLTGDRVTLGGRPLRPEAGDRDAGNAFDGSATGAEGTGMTFGTDVDGFRSTLGRNPVLKVSTGRDVLLFGAAVVRVRARS
>NC_013595.1|WP_012887173.1|391260_392442_+|NYN-domain-containing-protein
MDRCALFVDAGYLLADGAMAVHGTRHREAVSWDYPGLLKLLGNLSKERTGLPLLRCYWYEASVEGRRTAEHDALADLPGLKLRLSRIRPGRREGVDAQVHRDLMTLARNSAVCDAVVVSGDEDLAQVVCDAQDLGIRVTVVHITADGSWAVSRSLRQECDDLIEIGSSHLRPYVSLAGAMETPALSNGHQPGGNGQAPASLGNGAPPAAPVVQAPRATPPPAPSQPALPSYPSYNHEPPQAPAPQQPQPAPAPQPLAAPNGPTGPLQPPPQAQQYASGNTGNMPGYQPGQLGAYTGPQAAPVPVQNASNSSTTTLSDAVKAAHKEGHDFGESVAKDAPALWLEAVLARKPRMPSDLEARLLQGSSLPIDFLLHDEVRHALRRGFWDALERARR
>NC_013595.1|WP_012887174.1|392554_394435_-|ABC-transporter-ATP-binding-protein
MREAEGPEGQEGRSSGAGSLFRRGQVAGELAWRAQPAAVAGSLVVVLLMGVAPVAAAWLTKLVLDGLAGGGGRSGLLPLAAALGVAGLALIVLPHVSEYLNGQLHRGLQRLIYDRLFRAVNADPGLSRFENPSFHDELRLAHEAGQNAPQQIVGSSLAICQGILTLLGFIVTLTVLSPVMVVIVIAAALPSARVQLALSRRRAGTMWGISSNTRRQIFFSALLTSPDAAKEVRLFGLGDFLRSRMLTELKTVNEAERDLDRRTLHSQGLLSLLGAAVAAGGLFWAVLTAIEGGLSVGDVSVFVAAVAGVQTALTLIVGQWASAHNALLMFGYYLGVVQADPGLPVAAEPTALPPLREGIELRDVWFRYDDGHPWVLRGVDLFIPHGQAVALVGLNGAGKSTLVKLLCRLYDPVRGSIHWDGVDLRDVHPDDLRARVGAVFQDYMSYDLTATENIMLGDLTAGADPELVRTAARRAGIHDTLDDLPRGYDTLLSRIFFGDNDDRQAGVTLSGGQWQRLALARALMRHHRDLLILDEPSSGLDAEAEHAVHLGLRRHRAGRTSVLISHRLGALRDADLIIVLSEGKITERGSHSELMALGGEYARLFSLQASGYELAPDPSAAPSGKP

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Crispr_ID: NC_013595_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_5

412383-412462

Orphan

Consensus_repeat	Method
CCGTCGCGGTCGCGGTCGACCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_5

>merge|NC_013595|5|412383-412462|CRISPRCasFinder
CCGTCGCGGTCGCGGTCGACCCGCGGGTGGGCCGCCGTCTGGGCCCGGTCGTCGACGCCGTCGCGGTCGCGGTCGACCAC

>NC_013595|5|5|412383-412462|CRISPRCasFinder
CCGTCGCGGTCGCGGTCGACCCG	CGGGTGGGCCGCCGTCTGGGCCCGGTCGTCGACG
CCGTCGCGGTCGCGGTCGACCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_148268916.1\|405879_406386_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012887184.1\|408748_409945_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|349949
NC_013595.1\|WP_043651147.1\|415904_416789_-\|DUF4429-domain-containing-protein	unknown	unknown	gnl\|CDD\|373084
NC_013595.1\|WP_012887189.1\|414015_414984_+\|magnesium-transporter-CorA-family-protein	unknown	unknown	gnl\|CDD\|213356
NC_013595.1\|WP_012887178.1\|401979_403746_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NC_013595.1\|WP_012887194.1\|419797_420502_+\|type-1-glutamine-amidotransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|153235
NC_013595.1\|WP_012887193.1\|418441_419701_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NC_013595.1\|WP_081453009.1\|420818_421094_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|274226
NC_013595.1\|WP_043651145.1\|412897_413962_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NC_013595.1\|WP_043651143.1\|410107_410659_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_013595.1\|WP_012887196.1\|421279_421927_+\|AmiS/UreI-family-transporter	unknown	unknown	gnl\|CDD\|259833
NC_013595.1\|WP_012887177.1\|396095_400274_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|237951
NC_013595.1\|WP_043654505.1\|415179_415866_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|377857
NC_013595.1\|WP_012887179.1\|403922_404756_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|236841
NC_013595.1\|WP_012887186.1\|410810_412094_+\|benzoate/H(+)-symporter-BenE-family-transporter	unknown	unknown	gnl\|CDD\|225677
NC_013595.1\|WP_012887197.1\|422026_423274_+\|acetamidase/formamidase-family-protein	unknown	unknown	gnl\|CDD\|376984
NC_013595.1\|WP_012887182.1\|406494_407646_-\|transcription-termination-factor-Rho	unknown	unknown	gnl\|CDD\|237171
NC_013595.1\|WP_043654498.1\|407892_408618_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293806
NC_013595.1\|WP_043654509.1\|416957_418220_+\|aminotransferase	unknown	unknown	gnl\|CDD\|372371
NC_013595.1\|WP_081453008.1\|400485_401934_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012887184.1\|408748_409945_-\|MFS-transporter	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	4.01412e-18
NC_013595.1\|WP_043651147.1\|415904_416789_-\|DUF4429-domain-containing-protein	gnl\|CDD\|373084	pfam14472, DUF4429, Domain of unknown function (DUF4429). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and viruses, and is approximately 90 amino acids in length. This domain is often found in two tandem copies.	2.86801e-28
NC_013595.1\|WP_012887189.1\|414015_414984_+\|magnesium-transporter-CorA-family-protein	gnl\|CDD\|213356	cd12822, TmCorA-like, Thermotoga maritima CorA-like family. This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	9.95931e-114
NC_013595.1\|WP_012887178.1\|401979_403746_-\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	3.67991e-54
NC_013595.1\|WP_012887194.1\|419797_420502_+\|type-1-glutamine-amidotransferase-domain-containing-protein	gnl\|CDD\|153235	cd03141, GATase1_Hsp31_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein. Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein (EcHsp31). This group includes EcHsp31 and Saccharomyces cerevisiae Ydr533c protein. EcHsp31 has chaperone activity. Ydr533c is upregulated in response to various stress conditions along with the heat shock family. EcHsp31 coordinates a metal ion using a 2-His-1-carboxylate motif present in various ions that use iron as a cofactor such as Carboxypeptidase A. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with a typical GATase1 domain, a reactive Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For EcHsp31, this Cys together with a different His and, an Asp (rather than a Glu) residue form a different catalytic triad from the typical GATase1 domain. For Ydr533c a catalytic triad forms from the conserved Cys together with a different His and Glu from that of the typical GATase1domain. Ydr533c protein and EcHsp31 are homodimers.	3.50086e-98
NC_013595.1\|WP_012887193.1\|418441_419701_+\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.28559e-37
NC_013595.1\|WP_081453009.1\|420818_421094_+\|transcriptional-regulator	gnl\|CDD\|274226	TIGR02605, CxxC_CxxC_SSSS, putative regulatory protein, FmdB family. This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions].	5.11359e-07
NC_013595.1\|WP_043651145.1\|412897_413962_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	9.11012e-38
NC_013595.1\|WP_043651143.1\|410107_410659_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.47973e-18
NC_013595.1\|WP_012887196.1\|421279_421927_+\|AmiS/UreI-family-transporter	gnl\|CDD\|259833	cd13429, UreI_AmiS_like_2, UreI/AmiS family, subgroup 2. Putative transporters related to proton-gated urea channel and putative amide transporters. This subfamily includes putative UreI proton-gated urea channels and putative amide transporters (AmiS of the amidase gene cluster). Helicobacter pylori UreI (HpUreI), a proton-gated inner membrane urea channel opens in acidic pH to allow urea influx to the cytoplasm. There urea is metabolized, producing NH3 and Co2, leading to buffering of the periplasm. This action is essential for the survival of H. pylori in the stomach, and has been identified as a mechanism that could be clinically targeted to prevent various illnesses associated with infection by H. pylori. UreI and the related amide channels (AmiS) appear to function as hexamers, and have 6 predicted transmembrane segments. UreI has also been shown have a lipid "plug" in the center of the hexamer. Urea enters at the periplasmic opening of UreI and must pass 2 constriction sites, one on each side of a conserved Glu (Glu 177, H. pylori numbering), to reach the cytoplasm. Urea/thiourea selectivity is diminished by mutation of a conserved Trp to Ala or Phe in constriction site 2 (cytoplasmic). Channel functionality is greatly diminished by mutation of a conserved Trp in constriction site 1 (periplasmic) and a conserved Tyr in constriction site 2, and to a lesser extent a conserved Phe in site 1. In the cytoplasm, urease hydrolyzes urea to form ammonia and carbamate, which decomposes to carbonic acid. UreI is fully open at pH 5.0 to facilitate urea influx, but closes at neutral pH, preventing over-alkalization. Glu 177 (H. pylori numbering) is present in urea channel proteins, but absent in the related amide channels, suggesting that it plays a role in urea specificity.	3.44458e-64
NC_013595.1\|WP_012887177.1\|396095_400274_-\|HAMP-domain-containing-protein	gnl\|CDD\|237951	PRK15347, PRK15347, two component system sensor kinase.	2.64872e-76
NC_013595.1\|WP_043654505.1\|415179_415866_+\|HNH-endonuclease	gnl\|CDD\|377857	pfam07510, DUF1524, Protein of unknown function (DUF1524). This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.	5.31041e-14
NC_013595.1\|WP_012887179.1\|403922_404756_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|236841	PRK11088, rrmA, 23S rRNA methyltransferase A; Provisional.	1.95886e-44
NC_013595.1\|WP_012887186.1\|410810_412094_+\|benzoate/H(+)-symporter-BenE-family-transporter	gnl\|CDD\|225677	COG3135, BenE, Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism].	2.62115e-103
NC_013595.1\|WP_012887197.1\|422026_423274_+\|acetamidase/formamidase-family-protein	gnl\|CDD\|376984	pfam03069, FmdA_AmdA, Acetamidase/Formamidase family. This family includes amidohydrolases of formamide EC:3.5.1.49 and acetamide. Methylophilus methylotrophus FmdA forms a homotrimer suggesting all the members of this family also do.	4.81503e-176
NC_013595.1\|WP_012887182.1\|406494_407646_-\|transcription-termination-factor-Rho	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	0
NC_013595.1\|WP_043654498.1\|407892_408618_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293806	cd07720, OPHC2-like_MBL-fold, Pseudomonas pseudoalcaligenes organophosphorus hydrolase C2, and related proteins; MBL-fold metallo hydrolase domain. Pseudomonas pseudoalcaligenes OPHC2 is a thermostable organophosphorus hydrolase which a broad substrate activity spectrum: it hydrolyzes various phosphotriesters, esters, and a lactone. This subgroup also includes Pseudomonas oleovorans PoOPH which exhibits high lactonase and esterase activities, and latent PTE activity. However, double mutations His250Ile/Ile263Trp switch PoOPH into an efficient and thermostable PTE. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	8.40641e-49
NC_013595.1\|WP_043654509.1\|416957_418220_+\|aminotransferase	gnl\|CDD\|372371	pfam12897, Aminotran_MocR, Alanine-glyoxylate amino-transferase. These proteins catalyze the reversible transfer of an amino group from the amino acid substrate to an acceptor alpha-keto acid. They require pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze this reaction. Trans-amination reactions are of central importance in amino acid metabolism and in links to carbohydrate and fat metabolism. This class of aminotransferases acts as dimers in a head-to-tail configuration.	0
NC_013595.1\|WP_081453008.1\|400485_401934_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	4.43566e-44

>NC_013595.1|WP_012887186.1|410810_412094_+|benzoate/H(+)-symporter-BenE-family-transporter
MTRLLQPVLAGVVTALVGFASSFAVVLAGLRAVGADQRQAASGLLALCLANGVVAIWLGLRQRVPITIAWSTPGAALLVATGAVEGGFPAAVGAFVVSGLLITAAGLFPPLGRWIAAIPTPIAGAMLAGVLLNLCVAPVRALGEVPLMAGPAVLTWALLSRFARKWAIPGALLVAVVAIALTGPGLGTVDVRPVAELTAPSWSVAAMISIAFPLFLVTMASQNVPGMAVLAGYGYRPPLRGILLGTGLASTLGAPLGGHAVNLAAITAALAAGPDADPDPGRRWIASVTAGASMIVLGVGSGLATALVLLSPPVLIEAVAGLALIGALASAITAAVAEPEGREAAVVTFVVTASGLTLLGVGAAFWGLVAGGAMTFLLRGRKAPRTAPGRSAPEGQTPGEPPPAETAPAEAGDREGAAGEGTRLSPR
>NC_013595.1|WP_043651143.1|410107_410659_-|helix-turn-helix-transcriptional-regulator
MDSGTQSPRPARDIGTPDVGQRIRRLREERGISLSELARRAGVGKATLSGLENGTRNPTLETLWAVTAQLGVPLALAVGTGPVIRGTAVEGVLLQVFEDEAVTYELYRLTIPAGATQVSPAHHEGVTEHITVFAGVLSAGPQDAPLRAGPGEHLTWRSDVPHTYAAIGDQDVHASLLMRYPHR
>NC_013595.1|WP_012887184.1|408748_409945_-|MFS-transporter
MFWATGVLAYVIAIFHRQSLGVSSIEAAARLGIGAAGLSTLAMLQILVYAAMQVPVGVLVDRIGSKRMLVAGAAVMACGELVFALSEGLLPGVAGRALIGCGDAMTFISVIRLVNLHFPAHRNPVMVQLTGLIGQLGAIASAVPLIHSLHTYGWTPTFMGAAGLGVLSVILLLTVLRDARPARTDGPPSLKAAWAEPGTRLGMWTHAATQCSAAAFLLLWGYPFLVQGQGLDPSTAGVLLSTLTLCGMACGPLLGYLAGRFPFHRSRMVLIVIGTTTGAWTAVLAWPGRAPLWLLVLLVVVLAANGPGSMIGFDYARTFNPAARIGAATGIVNGGGFVASVSVIALVGITLELIGETDLDAFRWAFAVQYPIWALGAVQVLRYRGKARRLLLSTQPGG
>NC_013595.1|WP_043654498.1|407892_408618_+|MBL-fold-metallo-hydrolase
MGASIRRPLPEMFPGGCHGGSDEWILHFHCYLLRDAAGRTVLVDTGIGPEDSPAASWAPVPGALGSELARVGVRPEEVDAVVITHLHSDHASGAVIGGVPVFANARHVFQRAEVDAAAEEVLAQVVRPLGERVQVVDGQADVLPGIRVFHTPGHTPGHQVVQVGELVLTGDVVLHPTQLADPRVTYLYDSDPELAVATRVELLERVRAARGMIATAHFAEPFTVLPPRDPGGPRVTSTVSA
>NC_013595.1|WP_012887182.1|406494_407646_-|transcription-termination-factor-Rho
MTIETTTKKRPRAARPPRPRESDAYLETVAGLLDVRDKTGYIRTHGYLPGVDDVRVPHAQIRQYGLRPGDHVVATTRKPYERLAEVESVNGSTDWRNRPDFADMTPIHPRERLRLETESVTSRVIDLFAPIGKGQRGLIVAPPKAGKTMVLQDLAAAITRNHPDCHLMVVLVGERPEEVTEMRESIHGEVAASTFDRPDRDHTALAELAVERAKRLAESGHDVVVLLDSLTRLGRAYNNLAPGGGRTLAGGLDAAALLPPRRFFGAARNLRDGGSLTILATALVETGSRMDDNLFEEFKGTGNMELRLSRALADKRLYPAVDLDASGTRREEILLDPQEHQLTWRLRRTLGGLEKQQALELLTDRLRETPSNAAFLQQVRQTT
>NC_013595.1|WP_148268916.1|405879_406386_+|hypothetical-protein
MRKSSLIGGLLASVLVAGLPAAADAAVSPAAKATVTAAVSAGATAPAGAKHHWGPVRSAAGHSGHAVADVWITDFSAETFAVSGTLRDRDPHRDHCAYIRARFHYTGGGTGWARPRSTCGPSGAFRLSSDGEITRVDVRVCVLDRGRRTTSSCHVDVIRAEDIANWPR
>NC_013595.1|WP_012887179.1|403922_404756_-|methyltransferase-domain-containing-protein
MGLTDIVEYLICPVCGAGFDLGDRVLRCAQGHAFDIARQGYVSLLTGSQAPGTADSTAMVAAREAFLGAGYFGPLAEAVAGACRTGAKVVADAGAGTGHYLAGALDRLPGAVGIALDVSKHAIRRAARAHPRLGAVVADVWRPLPVGDGTVDVVLNVFAPRNGAEFARVLKDDGVLVVVTPTSRHLEPLVERLGLLSVDESKERRVAESLSGHFVETGRSVHEFGMTLGHGAIEAVVGMGPSAWHTEPEVMRRKIMKLPETSNVTASFRMSIFQPAP
>NC_013595.1|WP_012887178.1|401979_403746_-|S9-family-peptidase
MKAEERWQARFRAPRVTLPVWARQAPARAVYRSNASGAWEVYAWDRAAGSMRQATARPKGTSHGTIDPTGQWIWWFSDTDGDEWGRWMRQPFTGGPDEPIDLAPGYPAGIALSATGEAAIGVARPGEGFQIHVVRPGGSTRPIYEHAEAASVAAMSLDGSLIAISHSEHGDSRHPALRVLRQNGDTVGDLHDGSGKGVLGLRFAPVQGDRRLLTLHERRGRREPLVWDPESDEQREIWLRDPGEITADWYGDGRSLLVVRANRGRTHLHRYDLAGGRLFPIETQHGVIDAATPRPDGSVEYSWSSGAHPPVIRSSNGHVVMNHGGPISPPSVPVEDVDVEGPGGRIHALVSRPERGSGPFPTIFLLHGGPTSQDDDSFVPQVAAWVDLGFAVVRVNYRGSTGYGSAWRDALVGEVGHIELSDVAAVRDVMVDRGIADPERLVLSGASWGGYLTLLGLGTQPKVWAAGIATVPIADHLATYEEETEALRAYHRALLGGSPGEQPERYANCSPITYVDQVEAPLLILAGENDPRCPIGQIETYVSRLAERGHEHSVYRYDAGHGSLVVSERIAQMSAQLEFARKHIRTEA
>NC_013595.1|WP_081453008.1|400485_401934_+|SpoIIE-family-protein-phosphatase
MTAWAATSVLAVAEQLAGELVAQAAQAPFEVVWSHLEDGVQVEVRQKGVPGGVPAGPTVPVDEWGVTFSGEHHTHWARLPLPGSAERTAAEWSTEEPSRGPIWMGFLADASDLLAGTLDPDMVPAIISQIVVPRLATWCAVYTWSGDGGPQRPAYLWHTDERRIDELREELATAQIPQAGGSMQLGDSQMLIIPLLARGRALGVMCLGRPDRFAEDAFQYAEDIGRRAALAMDNARLYATQAAANRALQRSLLPPNEPGEIPGLDPAVVYEPAGETNEVGGDFYDLFAAGDDSWRFAVGDVCGTGPEAAAVTGLARHTLRLLAREGYGVAAVLDRLNQAILDEGERARFLTLLHGEIKPVPTGLDVWMVSAGHPEALRLRPTGVVETVVTSQSLLGVFPEATFKAEVVHLDPGDVLLAVTDGVTERRQGGRLLDDDGGLAKLFAECVGLSARAVAERIRRAVQDFAPEPSADDMAIVVLRAR
>NC_013595.1|WP_012887177.1|396095_400274_-|HAMP-domain-containing-protein
MTTANTVPDVEERRYSESDLKPILQTLITWRDGDFRRRVPHAPPGILSEIRLLLNEVADRREHLANELHRVRREVVKEGRFSERLTAGPGVGSWAESVDSVNSLIDALVGPVTGAADVIDAVAKGDLSRRIDLDRRARGEVRRLGKAINGMVDQLSLFTSEVTRVAREVGTEGRLGGRANVRGMSGSWRDLTEAVNTMSSRVSAQVRDIALVTTAVARGDLSRKVTVDAVGEMFELKNTVNTMVDQLSAFAEEVTRVAREVGTEGELGGQAQVRGVSGVWKDLTDNVNVMASNLTTQVRAIAAVSTAVAQGDLSKKITADAQGEILQLKDTLNTMVDQLSMFADEVTRVAREVGTEGQLGGQARVRGVSGVWKDLTDNVNSMANNLTYQVRNIAEVTTAVATGDLTRKIDVDAQGEILALKTTINTMVDQLSSFASEVSRVAREVGSEGQLGGQAQVRGVSGTWKDLTDNVNVMANNLTTQVRQIAAVSTAVAQGNLSKKITADAQGEILQLKDTLNTMVDQLSMFADEVTRVAREVGTEGQLGGQARVRGVSGVWKDLTDNVNSMANNLTYQVRNIAEVTTAVANGNLTRKIDVNAQGEILALKTTINTMVDQLSSFASEVTRVAREVGSEGKLGGQARVEGAEGIWKRLTENVNELAGRLTTQVRAIAEVTTAVATGDLTRSITVDAGGEIGELKDNINTMVSVLRDTTKANQEQDWLKSNLARISRLMQGHRDLMEVAKLIMSELTPLVSAHYGAFYLAEPTGDHDLFMIAGYGARPGSKIRNRFAVGEGIVGQAAFEGKRIILESVPAQYLTVDSGLSSSVPAQIVVVPILFETQVLGVVELASFSQFGEVHHDFMTQLVETIGVTMNTIIANSRTEDLLTESQRLTTELQERSDELQRQQEELRRSNAELEDKAALLAKQNRAIEIQNFQIEQARRTLEERAEQLAVSSRYKSEFLANMSHELRTPLNSLLVLAKLLTENAEGNLTVQQVEFARTIHGAGSALLQLINDILDLSKVEAGRMDIHPQQISLPKLVDYFEATFAPLAQDKGLSFAVEVDSSVPQELRTDEQRLQQVLRNLLSNAIKFTPKGEVRLRVIHAQRAVAFVDDTLRGADGILAFEVVDTGIGIAADKLEVIFEAFRQADGTTSRKYGGTGLGLSICREIARLLGGEIHVVSEVGQGSTFTLYLPPSYGGPLSSRDGGAAAPNSSPRNQTLIGVLEEPDDLPELALPEELPVSHFPQNEGPAWKGGDDPLTGAKILIVDDDIRNVFALTSVLERYGSTVVYAENGREGIEQLERNEDVALVLMDIMMPEMDGWATTSAIRRMPQFADLPIIALTAKVMQGDREKSIASGASDYVPKPVDVDRLLERLRGWLTRGKPAGDSDEGA
>NC_013595.1|WP_043651145.1|412897_413962_+|NAD(P)/FAD-dependent-oxidoreductase
MAEIDVVVIGAGQAGLSSAYFLSRAGVDFVVLDRSPRPGGAWQFRWPSLTLGAAHRVHDLPGLPMGAADTTRPSSEVVSEYFAAYERAFGLPVRRPVAVRAVREGVGGRLLVETSAGDWSPRALINATGTWDRPFWPRYPGQETFLGRQLHTADYVTREEFAGRHVVVVGAGASAIQLLMEIAEVATTTWVTRRPPVFREGPFDEEAGRAAVARVDARVRAGLPPGSVVGATGYPVTPQVEAAMAAGVLDRLPMFDRIVPDGVAWDGAAAGHPGRVRADVILWATGFRPVVNHLAPLHLREPGGGIRVEDTRAVLDPRVHLVGYGPSASTIGANRAGRAAVRHVRRLLDAPVAA
>NC_013595.1|WP_012887189.1|414015_414984_+|magnesium-transporter-CorA-family-protein
MDRTRLYRNGVLEAEGFPIEDVSDHIGDPSVVVWFDLCSPSPADLEKISEELGLHRLAVEDALHSDQRPKLDTYDSHLFITVYGAKLVRKRLELTEISIFVTKNALVTVRESPHFDIDGVIRRWDANGEMARYGVPYLLHGLLDYVVDGYFDVLQVIDDKVEALEDDLFEDNDADRVHIQRQTYEMRKSLVRFRRLAVPIREVVGSLLRKGVEMLDPALTPYYQDLYDHALRASEWTDSLRELVGNVREAHINQQGFRLNDIMKKITSWAAIIAVPTMITGYYGQNVPYPGFGQPLGFWTSTAAILVASSILYLIFKKRGWL
>NC_013595.1|WP_043654505.1|415179_415866_+|HNH-endonuclease
MFSLVSPADSKTRAAPESRARVAPLDNPHGTRPGLAPVRLARDRIAAIRLIKKLRIRGMGPKTGYTRARFGANWADTARGVPYARNGCGTRNDLLARDGEQVRYRRGSDCVVVAMSLRDPYTGRTIRWRKQRADQVQVDHVIPLSYEWRMGASRWPMAKRVRIANDPLNLIPVYGDANQAKGGSGPASWLPPLRRIRCAYVVRFAQVALKYGLPVTRADKAVMLAQCR
>NC_013595.1|WP_043651147.1|415904_416789_-|DUF4429-domain-containing-protein
MAEVMVRDGTWTFDGEILRIVPSRDRGVHKLRQLLGEVAVPLAAVAGIAYEPGKKGGRLRLRLREGADPFTQASRGRISDSACPYQLAVDAGRTGAAEYFVDEVRNALVIEQVPDGPSDRYLMPGPGVPLTVGGGDGTATFDGESFRIEWNWAVEGAKKSAGSQQFPLKDLLGLEWIPSVGLENGHLRFNLRGSVHKLAPKHDPHCLVLWGLEKETRAAALFVAAVLARLPHPSGAAEPQPALDAPAPAAPAAAGDADPDALLRRLRELGDLHRDGVLTEEEFTVAKQALLRRF
>NC_013595.1|WP_043654509.1|416957_418220_+|aminotransferase
MNLDELTAQRDRALRDYEALVQRGLSLDLTRGKPSGRQLDLASALLALPGGHTAADGTDCRNYGGLQGLPEIREMFGGLLQVPAGQLIAAGNSSLSLMHDSIVHALLGRVPGAERRWVEEPRIAFLCPVPGYDRHFALCERFGIELIAVPMTAEGPDMDVVERLVLEDPQVKGIWCVPKYSNPSGVSYSDETVRRLAAMPAAAPDFRIFWDNAYAVHHLTDTPVEIADLLALCAESGNPDRAFVFGSTSKITFSGGGVAFFGSSPANVAWLLGHMAKGTIGPDKINQLRHVEFLRDEDGVLEHMRRHRELIRPKFDAVDLILTKELGGTGLASWSNPAGGYFIGLDVLEGCARQVVSRAAEAGIALTPAGATHPYGDDPRDSTIRIAPTYPELDEVELAIAGLAVCVRLVGTEKLLEQAR
>NC_013595.1|WP_012887193.1|418441_419701_+|MFS-transporter
MSSRILPPSGPPRVLALAQLTNAFGDGAYYVCSALYFTRIVGLSPTQVGFALTLGWALGSVAGVPLGHLADRWGARGAAALLAVATGVAAGSFLFVTSFALFVLAACLYTCCQCGLGAARQALLAGLVDKARRTEVRAHLQATVNAGLAIGAALGGLALHLDTRQAYLAVFAMDALSFLASALVLLRLPAVPPSPPAPAGEPVLAVLRDRPYALISLLNMIMLLHMPLLSLVIPLWIVQRTEAPSWTVSALLVLNTLSVVLFQVRVARRVTGLGTASRSVRQAGLVMLASCAVFALSAAGSSAWAAGAALLVAACLQVLGEMMHASGAWEVGFDLAPQDRQGQYQGFFGAGTAVARMLGPLLLTTLIITWGPPGWLLLGGLFLLAGSAMGPAVRWAERTRAAGSPRPAVAPPLPQESAS
>NC_013595.1|WP_012887194.1|419797_420502_+|type-1-glutamine-amidotransferase-domain-containing-protein
MAATKKILVIVTNVGEYEKVGMRTGLWLGELTHFWDVAEQAGIPMDIASPLGGKIPLDPESLSHEVLAELGTEKRYRDRKFMDLLEDTKKISEVNLEDYDAIYLTGGHGVMFDFPQSRDLEDLMAGFYESDRIVSTVCHGGTGLLNVTLGNGDPLVKGKRVTGFSWPEEELADRADAVPYNLQEELQKLGADYRMADRPFEPYVVEDGRLITGQNPGSARGVAEAVVRRLTAVA
>NC_013595.1|WP_081453009.1|420818_421094_+|transcriptional-regulator
MATYEYLCRNCGRFDVRLPIGTAPLSHDCSTCGRGAPRVFSPPGFSRVHPALSAALDRDERSRDAPEVVSGVPGRRPPRPPHPALARLPRP
>NC_013595.1|WP_012887196.1|421279_421927_+|AmiS/UreI-family-transporter
MGAVGLLYVGAVLFINGLMLLGKVDPRAAGIFNLFVGALQVITPIVLIITANGRPDVILGASGIFLFGFTYLYVGIGLLGGFDTTGIGYFSLFVAIMALGYAFANFQVLNDRPFAVIWLYWAFLWLLFFLLLGLKRDHLTTYTGWVTAIEGWVTGAIPAFLILIGYWQRWNQNVIATLLLVFGVVVFGALWPLTRKRGALSSRAGPAGGETITAH
>NC_013595.1|WP_012887197.1|422026_423274_+|acetamidase/formamidase-family-protein
MPEVVFSVDQSKSMRDQAVPGHNRWHPDIPAVAMVRPGDEFRVECREWTDAQLHNDDSANDVRDVDLTLAHMLSGPIGVEGAEPGDLLVVDILDLGPVPQQTGDAPGQGWGYTGVFAKVNGGGFLTDYFPDAYKAIWDFHGIYATSRHLPGIRYAGITHPGLFGTAPSAELLASWNQREQALIDTDPDRVPALGLPPLRDNALAGTATGDVADRIAREGARTVPARENGGNHDIKNFTRGARVFYPVHVKDAKLSGGDLHFSQGDGEITFCGAIEMGGFIDFHVDLIKGGMEKYGVTTNPIFMPGNVEPRYSEFMSFIGISVDHDTNTNYYLDATVAYRRACLNAIEYLKKWGYTGEQAYLLLGSAPIEGRISGIVDIPNACCSLYLPTEIFDFDVRPNAEGPVKKDRGQCAVTS

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Crispr_ID: NC_013595_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_6

563836-563986

Orphan

Consensus_repeat	Method
CGGTGCGCCTGCGCGCGCCCGGACGGTCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_013595_6

>merge|NC_013595|6|563836-563986|CRISPRCasFinder
CCGGGTGCGCCTGCGCGCCCGGACGGCCCGATCACGCCCGAGGGCAGATCACCGATACCGGCGGTGCGCCTGCGCGCGCCCGGACGGTCCCGCGTTGCCTCCCACTTCAGGACAGCCCCGTACGGTGCGCCTGCGCGCGTCCGGACGGTCC

>NC_013595|6|6|563836-563986|CRISPRCasFinder
CCGGGTGCGCCTGCGCGCCCGGACGGCCC	GATCACGCCCGAGGGCAGATCACCGATACCGG
CGGTGCGCCTGCGCGCGCCCGGACGGTCC	CGCGTTGCCTCCCACTTCAGGACAGCCCCGTA
CGGTGCGCCTGCGCGCGTCCGGACGGTCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012887334.1\|571598_573062_-\|cytosine-permease	unknown	unknown	gnl\|CDD\|271377
NC_013595.1\|WP_012887328.1\|566258_566738_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012887330.1\|568444_569290_-\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NC_013595.1\|WP_012887317.1\|552680_553388_+\|redox-sensing-transcriptional-repressor-Rex	unknown	unknown	gnl\|CDD\|235486
NC_013595.1\|WP_012887316.1\|552141_552390_-\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|368604
NC_013595.1\|WP_012887329.1\|566950_568336_-\|amidase	unknown	unknown	gnl\|CDD\|223232
NC_013595.1\|WP_086012329.1\|565460_566099_-\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NC_013595.1\|WP_012887321.1\|557689_558676_+\|porphobilinogen-synthase	unknown	unknown	gnl\|CDD\|236450
NC_013595.1\|WP_012887331.1\|569294_569696_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100004
NC_013595.1\|WP_012887333.1\|570799_571531_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_013595.1\|WP_148268926.1\|550574_552152_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|236090
NC_013595.1\|WP_148269441.1\|560187_561444_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_013595.1\|WP_169369192.1\|564168_565464_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607
NC_013595.1\|WP_179949556.1\|555769_557299_+\|uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|376850
NC_013595.1\|WP_012887323.1\|559549_560191_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_013595.1\|WP_012887335.1\|573346_573814_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380345
NC_013595.1\|WP_012887332.1\|569811_570564_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012887318.1\|553482_554805_+\|glutamyl-tRNA-reductase	unknown	unknown	gnl\|CDD\|234592
NC_013595.1\|WP_012887322.1\|558868_559510_+\|bifunctional-DNA-primase/polymerase	unknown	unknown	gnl\|CDD\|378140
NC_013595.1\|WP_012887319.1\|554801_555722_+\|hydroxymethylbilane-synthase	unknown	unknown	gnl\|CDD\|234612

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012887334.1\|571598_573062_-\|cytosine-permease	gnl\|CDD\|271377	cd11484, SLC-NCS1sbd_CobB-like, nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain. This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	5.49702e-75
NC_013595.1\|WP_012887330.1\|568444_569290_-\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	3.46686e-84
NC_013595.1\|WP_012887317.1\|552680_553388_+\|redox-sensing-transcriptional-repressor-Rex	gnl\|CDD\|235486	PRK05472, PRK05472, redox-sensing transcriptional repressor Rex; Provisional.	1.2542e-113
NC_013595.1\|WP_012887316.1\|552141_552390_-\|glutaredoxin-family-protein	gnl\|CDD\|368604	pfam05768, DUF836, Glutaredoxin-like domain (DUF836). These proteins are related to the pfam00462 family.	4.63519e-23
NC_013595.1\|WP_012887329.1\|566950_568336_-\|amidase	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	5.83661e-152
NC_013595.1\|WP_086012329.1\|565460_566099_-\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	5.77922e-20
NC_013595.1\|WP_012887321.1\|557689_558676_+\|porphobilinogen-synthase	gnl\|CDD\|236450	PRK09283, PRK09283, porphobilinogen synthase.	0
NC_013595.1\|WP_012887331.1\|569294_569696_-\|RidA-family-protein	gnl\|CDD\|100004	cd00448, YjgF_YER057c_UK114_family, YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	1.94576e-32
NC_013595.1\|WP_012887333.1\|570799_571531_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	6.5323e-24
NC_013595.1\|WP_148268926.1\|550574_552152_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.07338e-05
NC_013595.1\|WP_148269441.1\|560187_561444_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.51665e-45
NC_013595.1\|WP_169369192.1\|564168_565464_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NC_013595.1\|WP_179949556.1\|555769_557299_+\|uroporphyrinogen-III-synthase	gnl\|CDD\|376850	pfam02602, HEM4, Uroporphyrinogen-III synthase HemD. This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea. This enzyme catalyzes the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O. Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis, such as HemD with pfam00590, however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease.	8.858e-63
NC_013595.1\|WP_012887323.1\|559549_560191_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.36084e-77
NC_013595.1\|WP_012887335.1\|573346_573814_+\|cupin-domain-containing-protein	gnl\|CDD\|380345	cd02215, cupin_QDO_N_C, quercetinase, N- and C-terminal cupin domains. This family contains quercetinase (also known as quercetin 2,3-dioxygenase, 2,3QD, QDO and YxaG; EC 1.13.11.24), a mononuclear copper-dependent dioxygenase that catalyzes the cleavage of the flavonol quercetin (5,7,3',4'-tetrahydroxyflavonol) heterocyclic ring to produce 2-protocatechuoyl-phloroglucinol carboxylic acid and carbon monoxide. Bacillus subtilis quercetin 2,3-dioxygenase (QDO) is a homodimer that shows oxygenase activity with several divalent metals such as Mn2+, Co2+, Fe2+, and Cu2+, although the preferred one appears to be Mn2+. The dioxygen binds to the metal ion of the Cu-QDO-quercetin complex, yielding a Cu2+-superoxo quercetin radical intermediate, which then forms a Cu2+-alkylperoxo complex which then evolves into endoperoxide intermediate that decomposes to the product. Quercetinase is a bicupin with two tandem cupin beta-barrel domains, both of which are included in this alignment model. The pirins, which also belong to the cupin domain family, have been shown to catalyze a reaction involving quercetin and may have a function similar to that of quercetinase.	8.22996e-23
NC_013595.1\|WP_012887318.1\|553482_554805_+\|glutamyl-tRNA-reductase	gnl\|CDD\|234592	PRK00045, hemA, glutamyl-tRNA reductase; Reviewed.	3.44134e-167
NC_013595.1\|WP_012887322.1\|558868_559510_+\|bifunctional-DNA-primase/polymerase	gnl\|CDD\|378140	pfam09250, Prim-Pol, Bifunctional DNA primase/polymerase, N-terminal. Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities.	3.23203e-22
NC_013595.1\|WP_012887319.1\|554801_555722_+\|hydroxymethylbilane-synthase	gnl\|CDD\|234612	PRK00072, hemC, porphobilinogen deaminase; Reviewed.	4.92421e-139

>NC_013595.1|WP_148269441.1|560187_561444_-|sensor-histidine-kinase
MTGSWLLIALEAVVIVVLPLSIIAAVLRYRLYGIDIVINRTLVYGSLVAVTGGVYFGLIWLANALASDLGSVAGAVAALAVGGVFHPARLRLQRVVDRMFAVERDPYRLADLLGRTGQGAQDPAAALGEVVAVIRGALGATGVGVEVRTGWGGPARVFRDGELRLGTQEVPLLWHAERVGTLLVAGAWPGREPLAVLARHLAELAHAVRLTADLHRSRERIRTTRDEERRRLGRELHDGLGPALTSVTLTLDEARRRLDTDPRAVEKLLVRVREEMTATIASVRELVYGLRPPALDDLGLEGALRASAGETAVTVDGALDDLPAAVEVAAYRIAQEALTNARRHAGPATVLIRLRRLPGELRVEVADDGVGLPESPAAGVGLTSMRERAAEVGGSCVIGRRPGGGTEVTARLPTEEAT
>NC_013595.1|WP_012887323.1|559549_560191_-|response-regulator-transcription-factor
MITVLIVDDHPVFRQGLRGLLSAMEIEVVGEASGGQEAVALAAELQPDVVVMDLQMPGGNGVEATRTIVRTSPRIGVLVLTMFRDDDSVFTAMRAGARGYLLKEAGAEEIGRAVHAVAAGEAIYGPEIARRVLTYFAGMPDPSRTAFPELTEREREVLELVAQGRGNNEIAGILFLSGKTVRNHVSNIFMKLQVADRAQAIVRAREAGLGGSG
>NC_013595.1|WP_012887322.1|558868_559510_+|bifunctional-DNA-primase/polymerase
MVGVPLTRRGRRRAHPKQTISSVLEYAALGWASCPGARPLQSGSRACSCDRVGCPDPGAHPLSVAWQMQATTDPTLLTHWWQREPEANVILPTGRVFDVFDVPAAAGLTALAGMDSAGSATGPVAANGDRVLFYVATRNVAEDEDEWWSCPLDFGPATIDEMPGLRWHCRDSYVLAPPSALPSGRTGSWLRPPDGRPLPDPLRVLDWLADLCD
>NC_013595.1|WP_012887321.1|557689_558676_+|porphobilinogen-synthase
MSAQFPIARPRRLRRMAAMRRMVAGTRLHPAELVLPLFVKEGIGEPNPIGSMPGVFQHTRDSLRKAAHEAAEAGVGGLILFGIPAVKDARGSAADDPDGIVQQAVADVVADVGDALVVMTDTCLDEFTDHGHCGILTPGGEVDNDATLERYAAAAVSQARAGSQVIAPSGMMDGQVAAIRAGLDADGFEQIPILAYAVKYASAFYGPFREAAECAPQFGDRNAYQQDAAGPVGEALREVRLDLDEGADWVMVKPALAYLDILRQVRDAVDVPVAAYQVSGEYAMIEAAAANGWIDRDRAIMESLVAIRRAGADMILTYWATEVAKKLQ
>NC_013595.1|WP_179949556.1|555769_557299_+|uroporphyrinogen-III-synthase
MGAGPGDEGLLTLRGADLLSKADVVVLDQEAYGTLLRHCREGVEVVEAADEDAVSLRTVTAAKGGRVVVRLCAGDPMFFSSITEEVAACAKAEVDFEIVPGVPPATAVLTYAGIPAAVAVPEFRVVDATQVDDWSAHATGAGTLVIYNGVSGAVAIGKALIAAGRPDSTPVAISSAGTTTEQYTVVTTLGRIAPDLKHAGMTEPALIVVGEAVGMRDQLSWFETKPLFGWRVLVPRTKEQSAGLVEQLRSYGAVPEEVPTISVEPPRTPQQMDRAIKGLVTGRYEWVAFTSSNAVKAVREKFEEYGLDARAFAGLKVAAVGEATARALVQFGVKPDLMPSGEQSSDGLLAEWPPYDSMLDPINRVLLPRADIATETLVAGLTELGWECDDVTAYRTVRAAPPPAPIREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHNVTVIAVIGPQTAKTAEEFGLRVDVMADRPSASALAAALAEYGAKQRQAALAAGDVPRRPSQTRRGARRRAK
>NC_013595.1|WP_012887319.1|554801_555722_+|hydroxymethylbilane-synthase
MSSVSSPLRLGTRRSLMATTQSGLVAARLTELTGRAVELVGVTTFGDVTKANLTQLGGTGVFVSALRDKLIDGEIDFAVHSLKDLPTTQDPRVVIAAIPPRDDPRDALVSTAKLADLPAGSKVGTGSPRRIAQLRVLRPDLEYVPIRGNADTRIGKVTSGELQGVVLAAAGLGRLGREAEISQVFEVEEMLPAPGQGALAVECRADRTDLIEFLSVLDDARTRAAVTAERAVLNALEAGCAAPVGAYSADDGQNLILTAAVVAVDGKRAVRKSTAGTLSAPMDLGRDLAAEMIAEGAGTLIGEQAH
>NC_013595.1|WP_012887318.1|553482_554805_+|glutamyl-tRNA-reductase
MSVLVVGLSHRTAPVALLERVSVSGDALVKLLHAVQQDACVAEVMAVSTCNRVEVYAEVDRFHAAVTAISELLSIHSGVPMEQLSNHLYVHYEDRAVEHLFSVGSGLDSMVLGEGQILGQVRSALKLAQEQGTLGPTLNELVQQALRVGKRSHTETGIDRAGASLVGVGLTLAERVLGPIQGKRALVVGAGSMSALSAATLQRAGVTDIVVVNRTHDRAVRLAQTVGGRAAELGDLARELAQADLVISCTGATDVVITADMVVAREMFLLDLALPHDVDPAVRRLPGVTLVDLESMQDGAADAETDDGGRAEAVVAVRGIVADEVAAYLSAERAARVTPTVVALRSKAADVVEAELGRLVARVPELDGRVRDEVTQTIRRVVDKLLHEPTVRVKQLAESPAGDHYAEALRELFDLDPKVPRAVRSIERIDAETSKKEVGR
>NC_013595.1|WP_012887317.1|552680_553388_+|redox-sensing-transcriptional-repressor-Rex
MIRRLSQARERGIPEATVARLPLYLRALNGMAERGLATVSSEDLAVAAGVNSAKLRKDLSHLGSYGTRGVGYDVEYLIYQISRELGLTQDWAVAIVGVGNLGRALANYGGFVSRGFRVAALLDADPEVVGDHIAGLNVEHIDELEAVIKRRGVSIVVLATPAAAAQQVADRVIAAGVTSILNFAPVVLAVPEGVDIRKVDLSIELQILAFHEQRKTDRMTGGPAMAEEWPEAVDL
>NC_013595.1|WP_012887316.1|552141_552390_-|glutaredoxin-family-protein
MAPQDHRITLLGKPGCHLCDDARTVIERVATELGVPWEERDITASEEDQDKYWEMIPVTLVDGVQHDFWRVDENRLRAALRA
>NC_013595.1|WP_148268926.1|550574_552152_+|antibiotic-biosynthesis-monooxygenase
MLAPLWLAIGTVQLLARKSGAGFASWLVGIALTIIASVIMMVDPILQDTTFTKSLPPGGRHWGLLPGYLLGAAHVGVALVLLGGVVLAVLRWRGGDDYDADNMHALLALGPTGLALIGAVSFTVPGLFTALLLFVTAAAVWYVVLRPLAPYEDEDEDDQPEDDWEDRRPVGRRAASEPRDVQVAGRRALPEESPRRSGLGDLVAEYRAGEQDVDYAARMQRQPPVQGDPFGGPATGTFMAGEYGMPSPGQPAGGGEYTRQPPMTGQFGMPPGNQATGEYDVPVNEYGRPTAPAAGGPAGPGRPTGPSTGEFARPDPLHGAQPGGSLQPMPADQAFGAPTGYGQSAAPGYGGAPGYGQGSDQGLGGAPGYGQAPDRGLGGPTGYGQSAAPGLGGQPAAGSAYPGAAADQPGGSSRPSPGIFGLLTVFTLIDGTGEAFDRLAEETLEAVRRSEPDTLVYVCHSVKSAPLQRIVYELYRDEVAYTEHQRQPHVERFVSERQNMVLATNVIELNVNAAKVMPLPMAFRL
>NC_013595.1|WP_169369192.1|564168_565464_+|glutamate-1-semialdehyde-2,1-aminomutase
MSRTENSEDLFARAREIVPGGVNSPVRAFGAVGGTPRFMASGQGPYITDVDGNRYVDLVCSWGPMILGHRHPAVVEALQNALAAGTSFGTATPGEVELAEEIVARVEPVEKVRLVSSGTEATMSAVRLARGFTGRSKVVKFAGCYHGHVDALLASAGSGLVTFGLPDTPGVTGASAADTVVLPYNSVEAVTEAFRAFGAEIACVITEACPANMGVVPPLDGFNATLRELCTAHGALLIIDEVLTGFRVSEAGWYGLDPVDADLMTFGKVMGGGLPAAAFGGRADVMAHLAPEGPVYQAGTLSGNPLACAAGLATLRACDDEVYDRVDASALVIGRAAADALAAAGVPHRLQRAGSLFSVFFTEDQVTDFDGAQKQNTAAYRAFFHAMLDQGVYLPPSAYEAWFLSAAHDDEALSRVADALPVAAKAAAQAS
>NC_013595.1|WP_086012329.1|565460_566099_-|Uma2-family-endonuclease
MNTPGDGDDVTVTDVSSALDYWPSPPPWGWTADDLDRLPAEGPNGEPDFFKHVELIDGALVFMSPQKRFHERMLFGLRVALNAQAPDHVAAIIEMDVKLGHRMRPCPDVLVIDAQAADDDDRTFYTPDEVHLVAEVVSPESEDRDRKTKPFRYAEAGIAHFWRVENNDGGPVVYVYELDPATGAYGLTGIHHGRLTVPVPFPIDIDLDKLPR
>NC_013595.1|WP_012887328.1|566258_566738_+|hypothetical-protein
MNAESDQTSDPFAPPNPAQARAHRVYASLFRIAERHAATEAQRSRQVHPDVLGPHEAIRIVSVLAGGAAEREEGEPEVDNADITAALTLIPLARAEMDQLEAGLLLMARGRGLTWQEIAFGLGLGTSQAARQRYERLAGRVTADGGGDGAGAETDDTDR
>NC_013595.1|WP_012887329.1|566950_568336_-|amidase
MSDLHFLGISELGPMLAARELSPVELCQALLARCASLDPLLNAFVSLPSERILADARVAEEELRRGDVRGPLHGVPIAVKDNIDVEGERTTAGSRVLADARATGDAVIVARLRAAGAIVFGKTNLPEFAYGPLDTYHYGPTRNPWDLHRYAGGSSMGSGSAVAAGLVPGAIGTDTTGSIRNPAAWCGVVGLKPTFGRVPTTGVVPLARTLDHAGPMARSAEDCAVLFDAVADRDPGRAGASHRKGAGRATPLRRSVRGLRAGVLRGFLWEPLSADTAAALTVALVALQDMGLEVVDVEVPAWKAAVEAGSTILACEASAEYRRFLRERPGDLIPQIRERLEGGLAVPAPDYVDALRATQRLRAELDELFTRVDVLVLPSRERTAPRMEATGRLTEPIGGPLYAVPLNGTGLPAVSIPCGFGSDGLPIGVQLAGPAWGEATLLALAHAYQKVTDWHARRPRP
>NC_013595.1|WP_012887330.1|568444_569290_-|fumarylacetoacetate-hydrolase-family-protein
MRLTTFQTPQGATTYGAVTDRGLVDLGARLGTRYPDLKSLIGDDATVVASEHLDKVDYAASDVTWLPVIPNPNKIICVGLNYEDHRAETGNSVSAQPAVFLRVPESQTGHDSPLLRPRESDTLDYEAEVAVVIGRSGRRITPDTAWRHVAGLSCYNDGSVREFQRHTHQYTPGKNFPRTGAFGPWMVTMDEIPADSALTLSCRLNGKIMQHATTSEMIFSIPRIISYVSTFTTLAPGDVIATGTPGGVGARRSPQVFMRPGDTVEVEIDKIGVLRNTISDD
>NC_013595.1|WP_012887331.1|569294_569696_-|RidA-family-protein
MAKQQVTSEAVSSPSGHFSQAIATQARGRLLFLSGMTARLPDGTVTGAGDIDAQTRRVCDNMKNLVEAAGGAMEDIVRVDVFVRNIEHFAAIHRVRREYFPSPPPASTLLEVSKMVHPDMLIEINAIAVIQDM
>NC_013595.1|WP_012887332.1|569811_570564_-|hypothetical-protein
MELLDFHPGGYRFIKVEGVFQFSSGVAAAPGFALERVRFARPVPLAEGFAAAERYLAAIGRPTTAFAACELRSSAPFTEQGFVDFNRVYVKTLERWGLYADGVNPVARTNVCPAYDKPEVPSLHAFSYTVESDSPHPTFVLAGNAECAQGPGEYRDSIVRRGETSIDAMRDKLRFVRAEQEERLRVLGLQWSHVLSTQAYTLHEVGPLLREEIFAYGAGTGAVTWHLASPPVVDCEFEMDARTVLREILL
>NC_013595.1|WP_012887333.1|570799_571531_-|GntR-family-transcriptional-regulator
MAIQPFNKAPLVDQVRGTILKAILDKQFVDKLPNEDDLAGMLNVSRTTVRGALASLEREGIITRRRALGTTINQHVHPSALALQRLVGFTDLLREKGHDVHVEADRSRVERLPKDLVAAFGDSLPDGETFLTDTRFYADGHLAICIRDAVPWSLLQDPSGLPQQGPPTQFDFARAYLVEPIDHAVVEILATVSRSGETRLQMPEGEAFTRLLERHYTREGRMMAVSLVDVDNGYVVFEVVRRM
>NC_013595.1|WP_012887334.1|571598_573062_-|cytosine-permease
MSAGDNERRELEEALHVDEIGIRPVPPEGRDATALQQFWIWAGANLAPISWIVGTVGIALGLSLLETILIAVIGQAVGALIFGLFALMGHRTGVNQMVLARATFGRRGAYLPALLQTLMATGWIGINTYVVLDLCLGIAHQMGLQPGDTVKYGLAVAIMIVQVVIGVLGFYAIRTFEKYTVPVVTVVMVIMTVVVLTRLEDISWTESSLAGGERFTAATQLLTAVGVGWGMGWITWASDYSRFTRPGVSPRRLYAASAMGIFAPLSWLSILGALSGTASQAGDPAEIVASLFGIMTVPVLFVILHGPVGTNIVNIYTASLGLLSLDMKLKRTTASLLTGVVGFLPLFVFIESESFAAGFTNFMSSVVIWLSPWAGVTLVDWYVIRRRQVECDALYADPRTSRYGDVNMRAVSAFLAGLASAWAFQYGAIEAFQGPVARAMGNVDLSWAAGMGVSAVLYFLLTRGRADVAAAPPARRVGSAGENVVSS
>NC_013595.1|WP_012887335.1|573346_573814_+|cupin-domain-containing-protein
MLRGIVVRGSEGKAYETGPALFKVGGRDTEGRIDFMIMDLEFHTGPKLHVHERQEDTFYILSGVLTIQMGEEVYDLEPGDFATVPPGLPHTFDNLREDQGPVRVINIMTPGGYEELFGEFDELPEGAGQEEIEAIYAKYEAKLVGPALHERLRRA

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Crispr_ID: NC_013595_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_7

632542-632688

Orphan

Consensus_repeat	Method
CGGGGAGCGGCGGGCTGTGGCGCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_013595_7

>merge|NC_013595|7|632542-632688|CRISPRCasFinder
CGGGGAGCGGCGGGCTGTGGCGCCCGAGGCCGCAGGTCCGCGGGCGGGCCGTGGCGCCCGGCGACCCGGGAGCGGCGGGCTGTGGCGCCTGGCGATCCGGGAGCGGTGCCCGGATCCGGAGGCCCGGGAGCGGCGGGCTACAGCGCC

>NC_013595|7|7|632542-632688|CRISPRCasFinder
CGGGGAGCGGCGGGCTGTGGCGCC	CGAGGCCGCAGGTCCGCGGGCGGGCCGTGGCGCCCGGCGAC
CCGGGAGCGGCGGGCTGTGGCGCC	TGGCGATCCGGGAGCGGTGCCCGGATCCGGAGGC
CCGGGAGCGGCGGGCTACAGCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012887397.1\|636667_637291_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_013595.1\|WP_012887399.1\|638131_639586_+\|sugar-transferase	unknown	unknown	gnl\|CDD\|274398
NC_013595.1\|WP_012887387.1\|628089_628881_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_013595.1\|WP_148268929.1\|630143_630461_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_081453019.1\|630601_631321_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|184971
NC_013595.1\|WP_012887386.1\|627535_627937_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240046
NC_013595.1\|WP_012887392.1\|632013_632505_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NC_013595.1\|WP_052316854.1\|633031_635014_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|377989
NC_013595.1\|WP_012887385.1\|626117_627518_+\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|236106
NC_013595.1\|WP_012887398.1\|637544_637889_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012887400.1\|639588_640656_+\|glucose-1-phosphate-thymidylyltransferase	unknown	unknown	gnl\|CDD\|273500
NC_013595.1\|WP_012887403.1\|642786_643437_-\|dTDP-4-dehydrorhamnose-3,5-epimerase	unknown	unknown	gnl\|CDD\|376414
NC_013595.1\|WP_012887395.1\|635256_635598_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227059
NC_013595.1\|WP_012887401.1\|640920_641943_+\|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|187557
NC_013595.1\|WP_012887402.1\|641939_642797_+\|dTDP-4-dehydrorhamnose-reductase	unknown	unknown	gnl\|CDD\|367904
NC_013595.1\|WP_012887391.1\|631265_631898_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_013595.1\|WP_012887384.1\|625576_626083_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_013595.1\|WP_012887388.1\|628892_630068_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_013595.1\|WP_012887383.1\|624656_625499_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|212492
NC_013595.1\|WP_012887396.1\|635798_636671_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012887397.1\|636667_637291_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	5.11896e-30
NC_013595.1\|WP_012887399.1\|638131_639586_+\|sugar-transferase	gnl\|CDD\|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	1.00219e-143
NC_013595.1\|WP_012887387.1\|628089_628881_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.07831e-31
NC_013595.1\|WP_052316854.1\|633031_635014_-\|sensor-histidine-kinase	gnl\|CDD\|377989	pfam08376, NIT, Nitrate and nitrite sensing. The nitrate- and nitrite sensing domain (NIT) is found in receptor components of signal transducing pathways in bacteria which control gene expression, cellular motility and enzyme activity in response to nitrate and nitrite concentrations. The NIT domain is predicted to be all alpha-helical in structure.	1.55047e-28
NC_013595.1\|WP_012887386.1\|627535_627937_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240046	cd04690, Nudix_Hydrolase_31, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	8.61804e-38
NC_013595.1\|WP_012887392.1\|632013_632505_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	1.29803e-21
NC_013595.1\|WP_081453019.1\|630601_631321_+\|NUDIX-domain-containing-protein	gnl\|CDD\|184971	PRK15009, PRK15009, GDP-mannose pyrophosphatase NudK; Provisional.	3.22791e-80
NC_013595.1\|WP_012887385.1\|626117_627518_+\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|236106	PRK07818, PRK07818, dihydrolipoamide dehydrogenase; Reviewed.	0
NC_013595.1\|WP_012887400.1\|639588_640656_+\|glucose-1-phosphate-thymidylyltransferase	gnl\|CDD\|273500	TIGR01208, rmlA_long, glucose-1-phosphate thymidylylransferase, long form. The family of known and putative glucose-1-phosphate thymidyltransferase (also called dTDP-glucose synthase) shows a deep split into a short form (see TIGR01207) and a long form described by this model. The homotetrameric short form is found in numerous bacterial species that incorporate dTDP-L-rhamnose, which it helps synthesize, into the cell wall. It is subject to feedback inhibition. This form, in contrast, is found in many species for which it serves as a sugar-activating enzyme for antibiotic biosynthesis and or other, unknown pathways, and in which dTDP-L-rhamnose is not necessarily produced. Alternate name: dTDP-D-glucose synthase.	1.97876e-148
NC_013595.1\|WP_012887403.1\|642786_643437_-\|dTDP-4-dehydrorhamnose-3,5-epimerase	gnl\|CDD\|376414	pfam00908, dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. This family catalyze the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.	1.60797e-92
NC_013595.1\|WP_012887395.1\|635256_635598_+\|hypothetical-protein	gnl\|CDD\|227059	COG4715, COG4715, Uncharacterized conserved protein [Function unknown].	0.0033789
NC_013595.1\|WP_012887401.1\|640920_641943_+\|dTDP-glucose-4,6-dehydratase	gnl\|CDD\|187557	cd05246, dTDP_GD_SDR_e, dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs. This subgroup contains dTDP-D-glucose 4,6-dehydratase and related proteins, members of the extended-SDR family, with the characteristic Rossmann fold core region, active site tetrad and NAD(P)-binding motif. dTDP-D-glucose 4,6-dehydratase is closely related to other sugar epimerases of the SDR family. dTDP-D-dlucose 4,6,-dehydratase catalyzes the second of four steps in the dTDP-L-rhamnose pathway (the dehydration of dTDP-D-glucose to dTDP-4-keto-6-deoxy-D-glucose) in the synthesis of L-rhamnose, a cell wall component of some pathogenic bacteria. In many gram negative bacteria, L-rhamnose is an important constituent of lipopoylsaccharide O-antigen. The larger N-terminal portion of dTDP-D-Glucose 4,6-dehydratase forms a Rossmann fold NAD-binding domain, while the C-terminus binds the sugar substrate. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.8223e-170
NC_013595.1\|WP_012887402.1\|641939_642797_+\|dTDP-4-dehydrorhamnose-reductase	gnl\|CDD\|367904	pfam04321, RmlD_sub_bind, RmlD substrate binding domain. L-rhamnose is a saccharide required for the virulence of some bacteria. Its precursor, dTDP-L-rhamnose, is synthesized by four different enzymes the final one of which is RmlD. The RmlD substrate binding domain is responsible for binding a sugar nucleotide.	2.02756e-123
NC_013595.1\|WP_012887391.1\|631265_631898_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.3259e-11
NC_013595.1\|WP_012887384.1\|625576_626083_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	2.22778e-41
NC_013595.1\|WP_012887388.1\|628892_630068_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.04245e-46
NC_013595.1\|WP_012887383.1\|624656_625499_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|212492	cd05327, retinol-DH_like_SDR_c_like, retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs. Classical SDR subgroup containing retinol-DHs, LPORs, and related proteins. Retinol is processed by a medium chain alcohol dehydrogenase followed by retinol-DHs. Pchlide reductases act in chlorophyll biosynthesis. There are distinct enzymes that catalyze Pchlide reduction in light or dark conditions. Light-dependent reduction is via an NADP-dependent SDR, LPOR. Proteins in this subfamily share the glycine-rich NAD-binding motif of the classical SDRs, have a partial match to the canonical active site tetrad, but lack the typical active site Ser. This subgroup includes the human proteins: retinol dehydrogenase -12, -13 ,and -14, dehydrogenase/reductase SDR family member (DHRS)-12 , -13 and -X (a DHRS on chromosome X), and WWOX (WW domain-containing oxidoreductase), as well as a Neurospora crassa SDR encoded by the blue light inducible bli-4 gene. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.17557e-29
NC_013595.1\|WP_012887396.1\|635798_636671_+\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.21799e-22

>NC_013595.1|WP_012887392.1|632013_632505_+|GNAT-family-N-acetyltransferase
MIEVELRGWRPDDAPALIRAFSSPDMAQQAARPIDTPEAALEWMGTWGFRDDAQAFAVVLDGQVVGNVAVSNIDAHANGWVSYWTSPQARGRGVAAAAARKLADWAFRERGLFRLELGHRLNNPASCAVATRAGFLPEGIERAKLSYEGMRYDVERHARLATD
>NC_013595.1|WP_012887391.1|631265_631898_-|GNAT-family-N-acetyltransferase
MTTVRPYRPDDRAALHDICVRTAHDGGDSRHIYSDLELMPSIFAAPYAFLEPELTFVLDDGDRAVGYVLGTADTVAFTEAFRSSWLPLMKERFPALGGPPTTPSETMIDLMYRPERMILPELAVYPAHLHIDLLPDHQRKGHGRALMNAFLDALHDRGVPAVHLGMVTANTPARAFYDRLGFHEIPVADPGPLTYLGRRTDRTAPPTAAA
>NC_013595.1|WP_081453019.1|630601_631321_+|NUDIX-domain-containing-protein
MDIPARPDDAKAGPPVPDGVPGVDVPDRRGRTGLDRAGRDLDGNPRVRVREVELLSSSWYILRRTTFDYLRTDGSWSAQERETYDRGNGATVLLYDAERATVLLTRQFRYPVYVNGHPDGLLLETAAGLLDDDDPETAIRREAAEETGYDIGEVRHVFDVYMSPGSVTERLHFFAAPYTADRRTSEGGGLADDGEDIEVVELPFAKALAMIGSGEIADAKTVMLLQWAALSGPFAGRDR
>NC_013595.1|WP_148268929.1|630143_630461_-|hypothetical-protein
MSDDAQGHDFRGNSLGDGSPDRPRTMGEIAVNLAVSEALANHGHHALVNAHETAADNHEIMARAGVGDVDEHLDLARWHRWCAIVEDQIADEADHRTPARRDRSS
>NC_013595.1|WP_012887388.1|628892_630068_+|SpoIIE-family-protein-phosphatase
MTAHDDAQVTGDALGVLEDLYEDAPCGYLSTRGDGMIIKVNRTMLALTGYRRQELVGRIRIHDLLAVGDRILYETHFAPLLALQAGVKEIAVDLRRADGSRVPVLLNAVMKEQTPARPEEIWIGVVAASDRRGYERELLQARQRAEESQRRAVELARTLQESFIPPELPRVPGMDVAGMYRPAGQGDEVGGDFYDMYEIVDGWALTLGDVCGKGVQAAVVTSLARYTLRAAPLRESRPSAILATLNEVLVNERTDRFLTAVYAQVHRDARDRFRLTLALGGHPPAFHLSKEGRVSMIGHPGTVLGILDSVELHDVTVDLAPGDVVVFYTDGVVEGRGRTGFFGEERMRQVLSASRDADAADIAGHLMDEVVAFQSGMPSDDIAIVVLKIPD
>NC_013595.1|WP_012887387.1|628089_628881_+|alpha/beta-hydrolase
MDIVARNNVKVAGRRGGRPMIFSHGFGCDQSMWRYVAPAFEDEYETVLFDYVGAGRSELSAYSAERYASLDGYAQDVLDVCEELDLTGAVFVGHSVSAMVGVLAAVREPRRLGTLILVAPSPRYIDDGDYVGGFSGADIEELVDSLDSNYLGWSSQMAPVVMGNPDRPELGEELTNSFCRTDPEIAKQFARTTFLSDNRDDLGKVAVPALILQCSHDALAPPQVGHYVHRAIPGSELTLMRATGHCPNLSAPEETIAAIKAFL
>NC_013595.1|WP_012887386.1|627535_627937_+|NUDIX-domain-containing-protein
MADPIDKVAWIRIEGGRILGARSRGKDVCYLPGGKREAGETDLDTLVREIGEELSVAIVRESGRFAGVFEARAHGHAEGLSVRMSCYEADYRGDLAPGGEVEEVVWLAYGDRHRVSPVVRLIFDSLRAEGRLA
>NC_013595.1|WP_012887385.1|626117_627518_+|dihydrolipoyl-dehydrogenase
MSTHYDVVVLGAGPGGYVAAIRAAQLGLSVAVVEERYWGGVCLNVGCIPSKALLRNAELAHIFTHEAKTYGIRVEGQVTFDYGEAFKRSRKVADGRVKGVHYLMKKNGITEYDGRGTFVDANTLQVAGRDGGAETVTFDHCIIATGATTKLLPGTSVTERVVTYEEQILSDKLPESIVIAGAGAIGVEFAYVLHNYGVKVTIVEFLDRVVPLEDEEVSAELARRYKRLGIEVLTSTRVESIDDSGEQVRVTVSREGQQQVIEADKVMQAIGFQPRVEGYGLERTGVALTERGAIDIDGRGRTSVPHIFAIGDVTAKLMLAHAAESMGIIAAETIADEETMELDYVMIPRATYCQPQIASFGFTEAQARELGYDVKVAKFPFTANGKAHGLGDVTGFVKLLSDGEHGELIGAHLIGPEVTELLPELTLAQQWDLTVHEVARNVHAHPTLGEAVKEAVHGLAGHMINM
>NC_013595.1|WP_012887384.1|625576_626083_+|helix-turn-helix-transcriptional-regulator
MSGTHTDVPSVIAFDLPLPVSVREYESCALTDVLRRVGDKWSVLLVVLLGRGPRRFNELHRVIDGISQRMLTRTLRGLERDGLVARTVHPTVPPSVEYALTDLGAALLVPLSAVADWAVDHHAGIESARDDYDTAGGAPVPAPPGEGAAVPGRRSPVPGGGGPEGHPR
>NC_013595.1|WP_012887383.1|624656_625499_-|SDR-family-NAD(P)-dependent-oxidoreductase
MSKIIVIAGATNGIGRGIALDRLRRGDVVVAVGSSAERGARLRADAEQAGAGDRLDFLRADLSSIAENDRVIDHVTARHPAIDALVLTANRQSAERRETAEGLEFTFALYYLSRYLLGYGLRGALEASPSPVILNVAGAGITAGAVMWDDLQLERRYGMLRAQLQGGRANDLLGVSFTEETGGTVRYVMYHPGFTDNGDFSHLPRPLSALVKLLARFAARSIDQVVPPLSGLLDTPPLQPLTAVDRGRTVPLTLRTFDPADARRLARLTEELLASRRTPR
>NC_013595.1|WP_052316854.1|633031_635014_-|sensor-histidine-kinase
MAIWAFAATLTFQSGQELLRASEGYERGVLPTRTVTTAIQHERLLSLSVLGGSTIARTELDAQRIRTNTARTELERLAPALREGTSPAVRDRLVKLLSSMERLTEIRSEVDTRTAGQTQTLDAYNAIVGAAFEVYDKIRVSSDIDMNDQTRAVVLMGRSREMLSQQAALIAGAVAEGSMSTDERAKFNDLAIGRKLLYSMGFNQFDEEFQELYRSLQNSGAYASFERIEKAVTTAGKPAPSWATVAAKVSDTFDDLGGEVSKGISDRSGPLATGILLQIGVAAGLGLVAVALSIFVSVRFGRRIGTELVGLQQAALDLAHSRLPDVVERLRRGEDVCSEAQELNHGTTTEIVNVGKAFSSVQRTAVEAAAGQAQMRKSVNKVFVNLARRSQSLLHRQLSMLEAMEQRASDPETLDDLFGLDHLTTRMRRHSEGLIILSGAVPGRGWRTPVTIYDVVRAAVEEVEDYQRVTVNVPQGPSVVGTVVTDVIHLVAELVENAAIFSPPHTMVSIQGEMVARGYAIEVEDRGLGITPDEMAQLNRRLADPPEFDLADSDRLGLFVVTQLAARHGIRVSLRPSPFGGTTAIVLLPGELVVAVPDRQAAYSAEVEWVTTGSGLPKRVRQAVPERRTAPAEASERAPSSVMTSFRDGWRRAEQEGGAE
>NC_013595.1|WP_012887395.1|635256_635598_+|hypothetical-protein
MKQIAELIGLEADRAAEATLVRGGELERSGAVQLVRFSPSLVTAEVDDGAAYVEFRVVDGVLRWYCTCAEGRSGALCAHCVATAQSVRRRTGGKASPGGSSTAASASTARIAL
>NC_013595.1|WP_012887396.1|635798_636671_+|EamA-family-transporter
MKLAVVGAAVLWGTAGTAGLLVAGVDPISLAAARLVVGGLVLAVAVGPAIRSLPRPALLLPAAVAVAAYQLCFFAAVSRTGVAIGTVVAIGSGPVFTGLLSWALDRVRPTRRWAGATAVAIAGCAVLTGGGGEVRLDGVLIALLGGLLYAFYAVTAARVISAGASSDAVMGAMFGGAAVVMLPVLLWTGTAWLTEPRGLLTALYLGCATTALAYILYGRGLRTTPVATAATLALAEPAVAALLGVVVLGEQLTLTSAAGLLLLGGSLAVVALPERWSGRRGRAAAIESSA
>NC_013595.1|WP_012887397.1|636667_637291_+|GntR-family-transcriptional-regulator
MTIPLRPVSAVSALADALRRRVLSGEMAPGTTLPEQELSAQYGVARPTVREALAVLVHEGLLRRERHRSAQVAEVTLADLDDLMFVRRPLEDLMATSLAGRRVAEADGALARMAGLPGDAPWSDVVAEHMALHQALIVAVGSPRLERLYATLAAETRLGLVRLRAVYADRDVLVAEHRDLLDAIGRGPAETARRAVAAHLDHGWGMD
>NC_013595.1|WP_012887398.1|637544_637889_+|hypothetical-protein
MHGNSVPDSYVYVTEEGVTRHYADGSVDALAWEDVVEVRVVGDPDILYILLDRDGQGCVVPQSATDTAFLARLRYLPDFDLDRLGEAVDAARDDYVVVWRSPEPPSPLPDFEYD
>NC_013595.1|WP_012887399.1|638131_639586_+|sugar-transferase
MRVGIQEPAVALLGSSVRAAPSIWTRSYARILLAGDLACAVVACEAVLGVRLWFGAYIPGTEALLGLGLALAWPFSLAVGGAYRKRAHGEGTEEFRAVFDGGVGLTAAVAIGAYATQTTIARSFVMAMFPLALILTIIFRYRMRKRLHRRRSFGEYMRQVVAVGHRESVLDLVMQLRRQPHHGMTVVAACLPSGSEGLDIDGVPVLGGFGDVPDVVAEVNADTVAILACPELDGAALRRLAWGLEDARTDLFVAPALMDVAGPRISIRPVAGMPLLHVEHPEFDGAKHLAKNLFDRVGAGLALLVLSVPMLVITLLIRATSTGPALFRQVRVGRGGREFDVVKFRTMVNDAERLKTDLQRHNEFDGVLFKMRNDPRITRVGAFLRRYSLDELPQLLNVLRGEMSLVGPRPPLPEEVKQYGEDVRRRLVVKPGMTGLWQVSGRSDLTWEESVRLDLRYVENWSLFLDLQILWKTWSAVTGGEGAY
>NC_013595.1|WP_012887400.1|639588_640656_+|glucose-1-phosphate-thymidylyltransferase
MKALVLAGGSGTRLRPITHTSAKQLVPVANKPVLFYGLEAIAAAGIREIGIVVGDTQAEIEAAVGDGSALGLQVTYIRQHAPLGLAHAVLIARDYLDDDDFVMYLGDNFILGGINGIVDRFVHDRPSAQIMLTRVGDPRQFGVAELDAGGRVIGLEEKPADPKSDLALVGVYLFTSAIHEAVAELKPSWRGELEITDAIQWLIQEGHEVESTVISGYWKDTGNVTDMLEVNRLVLESLDGRVDGRVDGASELIGRVVVEPGAVVERSRIVGPAIIGAGARVLDSYVGPFTSIAADCVVSGSEIEYSIVLPRSSISGVSRIEASLIGHDVEVTPAPNTPRAHRLVLGDHSKVQISS
>NC_013595.1|WP_012887401.1|640920_641943_+|dTDP-glucose-4,6-dehydratase
MKILIIGGAGFIGSHYVRTLSADGVAVTVLDKLTYAGNPANLEGAAHEFVHGDICDAGLLAEVVPGHEVVVNFAAESHVDRSIDGAGEFVRTNVLGTQTLMQACLDAGTRRVVQVSTDEVYGSIDTGSWKEDAPVRPRSPYSAAKAGGDMIALAYAVTHGLPVSITRCGNNYGPHQYPEKVIPLFVTNLLRGRKVPLYGDGGNVRDWIHVDDHCAGIRLVAERGEPGEVYHIAGTAELTNTELTARLLAACGAGWDMVEHVEDRKGHDRRYSLDDSRLRALGYRPNIPFDQGLAETVRWYADNPDWWEAATDRRGGDGAGAGRRAGLAAVGAEQTGGTIA
>NC_013595.1|WP_012887402.1|641939_642797_+|dTDP-4-dehydrorhamnose-reductase
MSRWLITGASGMLATELLGRLQAAGESVLALRRDELDLRDGPAVRHLVSACRPDTVVNCAAWTAVDDAETREAEALAVNGHGVRALAEACERLGARMIQPSTDYVFDGTALDPYREDARTCPVNAYGRTKLAGEHAVLEVLPETGYVVRTAWLYGATGKNFVRTMAELERTRPSLEVVDDQVGPPTWAGDLAAGIIELGRTGPPPGVYHATGSGQTSWYGFAREIFKLVGADPDRITPVSTKEFARPAPRPAYSVLGHERWSLAGLPPMRDWREALRGSDVLLRD
>NC_013595.1|WP_012887403.1|642786_643437_-|dTDP-4-dehydrorhamnose-3,5-epimerase
MEPLSIDGTWCHTPRIHADPRGSFLESYRAADLEESVGHRLDLAQVNCSVSRRGVLRGIHFADVPPGQAKYVTCVSGAVLDVVVDIRVGSPTFGRWETVLLDDESRRGLYVAEGLGHGFLTLSEQATVVYLCSRPFTPGREHGIHPLDPALGIDWPAGVEPLLSDKDAAAPTLKEALDAGLLPDHGACAAYYAGLAAAGRDRDPATRGPDLAAPSL

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Crispr_ID: NC_013595_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_8

1065457-1065558

Orphan

Consensus_repeat	Method
GGCGGGGGCCGCGGGACCGGAGCGG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NC_013595_8

>merge|NC_013595|8|1065457-1065558|CRISPRCasFinder
GGCGGGGGCCGCGGGACCGGAGCGGATCTTTTCAGCGTGGCGGGGGCCGCGGGACCGGAGCGGATCTTTTCGGCGCGGCGGGGGGCCGCGGGACCGGAGCGG

>NC_013595|8|8|1065457-1065558|CRISPRCasFinder
GGCGGGGGCCGCGGGACCGGAGCGG	ATCTTTTCAGCGTGGCGGGGGCCGCGGGACCGGAGCGGATCTTTTCGGCGCG
GCGGGGGGCCGCGGGACCGGAGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012887785.1\|1054910_1056074_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|169028
NC_013595.1\|WP_148269461.1\|1070026_1071409_+\|DUF2079-domain-containing-protein	unknown	unknown	gnl\|CDD\|370724
NC_013595.1\|WP_012887802.1\|1073116_1074991_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173850
NC_013595.1\|WP_043651369.1\|1059201_1059960_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NC_013595.1\|WP_012887803.1\|1075188_1075920_-\|methyltransferase	unknown	unknown	gnl\|CDD\|369778
NC_013595.1\|WP_043651372.1\|1060590_1061490_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_013595.1\|WP_043654765.1\|1057436_1058834_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_013595.1\|WP_012887794.1\|1064822_1065236_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_013595.1\|WP_169369258.1\|1076050_1078075_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226418
NC_013595.1\|WP_012887796.1\|1067021_1067837_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NC_013595.1\|WP_148269460.1\|1069256_1069943_+\|class-F-sortase	unknown	unknown	gnl\|CDD\|320678
NC_013595.1\|WP_012887790.1\|1060040_1060310_-\|DUF1876-domain-containing-protein	unknown	unknown	gnl\|CDD\|378103
NC_013595.1\|WP_148268959.1\|1056639_1057422_-\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|369561
NC_013595.1\|WP_012887793.1\|1063505_1064474_+\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_013595.1\|WP_012887786.1\|1056139_1056643_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012887797.1\|1068132_1069053_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226406
NC_013595.1\|WP_012887800.1\|1071484_1072630_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|181123
NC_013595.1\|WP_012887795.1\|1065733_1067020_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NC_013595.1\|WP_012887801.1\|1072683_1072857_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012887792.1\|1062150_1063278_+\|glycerophosphoryl-diester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176544

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012887785.1\|1054910_1056074_+\|FAD-dependent-monooxygenase	gnl\|CDD\|169028	PRK07588, PRK07588, FAD-binding domain.	5.78232e-92
NC_013595.1\|WP_148269461.1\|1070026_1071409_+\|DUF2079-domain-containing-protein	gnl\|CDD\|370724	pfam09852, DUF2079, Predicted membrane protein (DUF2079). This domain, found in various hypothetical prokaryotic proteins, has no known function.	1.30138e-46
NC_013595.1\|WP_012887802.1\|1073116_1074991_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173850	cd01161, VLCAD, Very long chain acyl-CoA dehydrogenase. VLCAD is an acyl-CoA dehydrogenase (ACAD), which is found in the mitochondria of eukaryotes and in some bacteria. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. VLCAD acts as a homodimer.	4.29091e-98
NC_013595.1\|WP_043651369.1\|1059201_1059960_+\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	8.51311e-07
NC_013595.1\|WP_043651372.1\|1060590_1061490_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.6136e-20
NC_013595.1\|WP_043654765.1\|1057436_1058834_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.59882e-54
NC_013595.1\|WP_012887794.1\|1064822_1065236_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	5.38185e-26
NC_013595.1\|WP_169369258.1\|1076050_1078075_+\|hypothetical-protein	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	1.57664e-64
NC_013595.1\|WP_012887796.1\|1067021_1067837_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	7.53856e-23
NC_013595.1\|WP_148269460.1\|1069256_1069943_+\|class-F-sortase	gnl\|CDD\|320678	cd05829, Sortase_F, Sortase domain found in the class F family of sortases. Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.	1.82905e-57
NC_013595.1\|WP_012887790.1\|1060040_1060310_-\|DUF1876-domain-containing-protein	gnl\|CDD\|378103	pfam08962, DUF1876, Domain of unknown function (DUF1876). This domain is found in a set of hypothetical bacterial proteins.	1.8826e-22
NC_013595.1\|WP_148268959.1\|1056639_1057422_-\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	6.41422e-50
NC_013595.1\|WP_012887803.1\|1075188_1075920_-\|methyltransferase	gnl\|CDD\|369778	pfam08242, Methyltransf_12, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.69697e-12
NC_013595.1\|WP_012887795.1\|1065733_1067020_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.71709e-11
NC_013595.1\|WP_012887797.1\|1068132_1069053_+\|hypothetical-protein	gnl\|CDD\|226406	COG3889, COG3889, Predicted solute binding protein [General function prediction only].	0.000188032
NC_013595.1\|WP_012887800.1\|1071484_1072630_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|181123	PRK07801, PRK07801, acetyl-CoA C-acetyltransferase.	0
NC_013595.1\|WP_012887793.1\|1063505_1064474_+\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	4.29455e-48
NC_013595.1\|WP_012887792.1\|1062150_1063278_+\|glycerophosphoryl-diester-phosphodiesterase	gnl\|CDD\|176544	cd08602, GDPD_ScGlpQ1_like, Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of putative bacterial and eukaryotic glycerophosphodiester phosphodiesterases (GP-GDE, EC 3.1.4.46) similar to Escherichia coli periplasmic phosphodiesterase GlpQ, as well as plant glycerophosphodiester phosphodiesterases (GP-PDEs), all of which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. The prototypes of this family include putative secreted phosphodiesterase encoded by gene glpQ1 (SCO1565) from the pho regulon in Streptomyces coelicolor genome, and in plants, two distinct Arabidopsis thaliana genes, AT5G08030 and AT1G74210, coding putative GP-PDEs from the cell walls and vacuoles, respectively.	2.42951e-141

>NC_013595.1|WP_012887794.1|1064822_1065236_+|STAS-domain-containing-protein
MTVFQTKTKTTKTQTRHGAGLRPVHPATTIVPLYGEIDIFTSPALRERLLRALRLSTGPLVLDLSRVSFCDVSGLAVLVGTQRRARALGITLRLAAPRSQTVRMLRVTGLDRVLMMHGSDQGEPETYSLPAQTRTGD
>NC_013595.1|WP_012887793.1|1063505_1064474_+|YafY-family-transcriptional-regulator
MLETSARLLRLLSLLQTPREWTGTDLAERLGVNVRTVRRDIEKLRTLGYPVHATPGAAGYLLGAGAKLPPLLLDDDEAVAVAVGLRTAASGTIAGIEETSLRALAKLEQVLPARLRHRVNTLQSVTVTVPSGGPVVDPDVLTAVAAACRAHEQLRFDYAGREGGPSVRRTEPHRLVHTGRRWYLVAWDLDRGDWRTFRVDRLRPRVPTGPRFTPRRPPDTDLAGYTARGVSTEVYRYQGRFTLHVPVHVAAEKIPPTIGVLEAVDEHSCTLRAGSNSLDELALYVGLFGYRFEVHEPPELVRRIRSLTALLAGSLPPSPPPS
>NC_013595.1|WP_012887792.1|1062150_1063278_+|glycerophosphoryl-diester-phosphodiesterase
MARHPRAARPTTPAQPPNAAQPPSTARPTGPSSAPLGGGARLPIVVAHRGASAFRPEHTLLAYEVAIRLGADYIEPDLVSTKDHVLVSRHENELSATTDVAGHPEFAARRTTKTINGGRVTGWFTEDFTLAELRTLRARERFPRRRPASTAYDGKAQIPTLEEIVLLAQKHGVGIYPEIKYPSYFASIGLPIEGPLLETLRRHGWDDACDPVFIQSFETGNLKRLRSVTRLRLIQLIGAGSGPPYDLLKSVNPPTCDDLVTPAGLRQIAAYATGIGVTTTRIVPVGSDGRLGAPTSLVQDAHQLGLQVHVATIRDENMSLPADYRRGDPAGRAYSRAAGDVTGWLARLYGLRVDGVLADNPGVARAVRDRLLTGG
>NC_013595.1|WP_043651372.1|1060590_1061490_+|alpha/beta-hydrolase
MVNVGDVELWTEEFGDPSHPPVLLVMGAMSQGVLWPDEFVGRLVAGGRRVIRYDHRDTGRSDTVDFDSHPYTWADIKADVLGLLDAYGIGAAHIVGHSAGGLLGQWIAAEQPDRVLTLTAIGSSPLGGREGQVLMRALMGQEQPPGSLPPPTPEFVEFFTKAAVNPPPAGRREQIDFQIELARVLHGPALPFDEDEQRRVEERLHDRAVDPAAVVNHQRAGTTASDFEPVGILHRVVAPTLVIEGTHEPVKPGHGAFIAQEIPGAELLMIEGMGHTLPPQVHRQLADAILEHTGDRPER
>NC_013595.1|WP_012887790.1|1060040_1060310_-|DUF1876-domain-containing-protein
MESKQWDVQIFISEDDNDDVTTARAVLMTPDGRRRECVAYARRNPEDQPVPAIGDELAAGRALADMAGKLMRDGAEDVAQLAGHAPRAW
>NC_013595.1|WP_043651369.1|1059201_1059960_+|hypothetical-protein
MSIMKAGVLAVLIGVAAVGAVQHSKPTSGQSSSWVVKRPGHSSVKRPASWTIRRPNPTGGRDRDRGFGRPGGPGVKRHGDWRVRRPGMDARRDRQWASGRPGGPALRGPDGWKARQQGPDARYDRDRGYGRSDGSAAGRGYGRSDGSAAGRGRDRGYGRFDGPAAGRGGDRGYGRSNGPDARNDGDWGYGRSDGPLTRRHRNRAFGRYEDWNGRRPGEGMVRRPSRAESGARPFRPGRGQARQDRPRAELEW
>NC_013595.1|WP_043654765.1|1057436_1058834_-|MFS-transporter
MTGRQKLVLALLLGSQFMVAVDFSILNVALPVVGAGLGFSLADLQWIATAFALTAAGFTLLFGRVADLFGRKRLFLGGMALLGLSSALGGLATSPGMLLVARVLQGLATAAVTPAGLSLLTTSFKEGPLRDRALGLNGALMSAGFTAGAILGGLLTDLLSWRWAFLINVPVAALVVILAPSAIPDSRPAGRSRLDVPGAVAVTGGLLTLVYGLTQAGETGWGDPATLAALVAGAALLAGFWFIEKRSADPLVPVQIMKRPTVVWGNAVGLIAFVTETSLVFLLTLYLQKVLGYSPLATGLAFGVLGLGTVIGGTFGGRAVGRMGNRATIVTGGVIQAVATVSLVALGTSGAWIWLLLAATFIGGVGNMFMIVGFMVTATSGLPDREQGLATGLATMTQQVGITMGIPIMSAIATARMTALDGSGPDAVLSGVSLAILVNSAVVLVGAVLAGAFLAPRRAEHAPVK
>NC_013595.1|WP_148268959.1|1056639_1057422_-|alpha/beta-hydrolase-fold-domain-containing-protein
MPGPPGTVRWEAATVPGPDHDVPLRVYRSGPAPRGVLVWAHGGSWSAGSAAGWHPACADLARAASATVVSVDYRLAPGHPHPAALLDVLAAMTWAQTISDGPIAVGGDSAGGTVAACAALVWRDRRLPLAAQVLVYPPIDPRCQAPSYSRDAEAFPSRAGLLAAWRAYRGTAGRHPAAGGATPLYSTPDEAADPTGLAPAIIAAGSLDPVADDARGYARHLQTAGNTVTFREFRGMRHGAFLTDPALRHWLGVTYSRRTP
>NC_013595.1|WP_012887786.1|1056139_1056643_-|hypothetical-protein
MNTTAPDHAAALLRHFADLRDRTHGDAVSRQDKERLFQQAVTLLDPYARQTLEEVDTHLLRGTGAVTATGTRRSPDGGVDAVWALSWPEQRATGISPIIIRAFYGAGFHHPHLRGGTVGEWPLNVFTPGQAAAELPTLRAVVTADLHNLVFQRDYRIIPAVTDGQAR
>NC_013595.1|WP_012887785.1|1054910_1056074_+|FAD-dependent-monooxygenase
MKNTNVLISGASIGGPALAYWLDRYGFNVTVVEKAPALRAGGQAVDFKGETHLTVLRRMGILEDVRRLQTGGTDQEIVDADGRRLAVIPGEFTGGEIEIKRGDLSRLLYDRTAAGCEYVFGDSITSLTETADGVHVTFERAAPRTFDLVVGADGIHSNVRRLAFGPEADHVAFLGHYYALAELPGDFGPVPKMYNEPGRMVAVGGPKAPAFFVFASEQLDYDRYDVEQHKRIVAEAYAGMGWRGPAIVDAVRRADDLYLDSISQVRIDHYARGRVVLLGDAAYGNTLGGFGTGLAVVGAYVLAGELAAAGGDHRLAFERYEEEFRGYAKVARSGNAGPFLAPGSPARIRMRNWTFKYGFLLGLMLKMTDMFATRITLKDYEPVRQAR
>NC_013595.1|WP_012887795.1|1065733_1067020_+|MFS-transporter
MISFLRGPGAHVNRLATTLYGYTFLNDFILLYPVYALLFVDTGLSTAEISSLFVIWSVTSLVLEVPSGVWADAVSRRLLLTLAPLLAAAGYALWIIAPSYWAFAAGFVLWGAAGALQSGAMEALVYTELDRLGAAGRYATIMGRGRALGTGATMVATAAAAPALAVGGYPMLGAASVLACLLCAAVATTFPEHRVESTESPEETPPGGYAAILREGVREMRSSRSVRRAVLLLAVVWAVWGSLEEYVALLAAATGVVAYAVPLLVLLVSAGVALGGVLATTGRRLTDRAFAGILAAGALALGAGAISGVPAGFAAIAVAFCLFEMATVLAGARLQDRITGPARATVTSLAGLGTDVAGILVYGGYAAASTVAGHDVIFAVFAVPYLVLALALTRGGGPRSGGERRRERRASGGRGASPDPAPPVGRFS
>NC_013595.1|WP_012887796.1|1067021_1067837_+|class-I-SAM-dependent-methyltransferase
MPAGPRGYRGRVGSSSAFDGVDPEIRALRASSFGGQAAAYAKERPDYPDDALLWALEPVSGRAPLRVLDLAAGTGKLTEVLLRHVADVVAVEPDAAMLAQLRRRLPGVRALAGTAERIPLEDGSVDAIVVGQALHWFDLDRSVPEMARVLAPGGVLAGLWNLDDDRVPWVQGMKEAAASTVSFRQWWPASIPLEGPHFRVVEHAEFAHGQRRTAESMAATIATHSHVLTLSKAERAELLARVLGYLRSTPETAHGEFELPITTVTVRALLA
>NC_013595.1|WP_012887797.1|1068132_1069053_+|hypothetical-protein
MLKSKTRRRVAVKTAAIAAACGGLFFGAVPAIASMAAAPLPVSYSCTAGTGGVAATYKLQMDITGPLAPTPNSTVVATWAIRQPAASPSLLAPSAIPATERLVFDGDALVTANPSIVPSELRTVGATAAAVAATSGAPLQLPAVMITMTPTATGVIAVQPGPFGLYLEPAAGPGSGNGVTLYDCDVATPAEASAAALLITVKPSAAGTGTGTPTPTPTPTPTPTPSNTNTGTTSPPKPTITVTQTETSKPAKDDRQIDETPGGGASTGGGGDAGPDARVIMLGGALMVAGAAAGGLVLRRRTATRG
>NC_013595.1|WP_148269460.1|1069256_1069943_+|class-F-sortase
MRSVLILAGVAGVITVLVGMLYMVAAPEQYGLADQRTTLPPRSQTNATGPADPYFQAEPTVPPPQPSIPPAPAMQPSTPVRVVIPRLGVNAPIRSVGLDKQGAIEVPPVTNPNLVGWYRSGPTAGEAGPAIMLGHKDTKSGSAVFSRLDEIRNGDVIEVHRKDGIVAVFTVGGLEQAEKAVFPTQRVYGESPNPQLHLITCGGTYDRATGHYTDNVIAYATMTSTRKA
>NC_013595.1|WP_148269461.1|1070026_1071409_+|DUF2079-domain-containing-protein
MGALVVLAAAVYSLLGLVKFATFRATTFDLVIFDQAVRGYAGFGAPTEPSVGMQYGMGMDFIQLADHFSPIVALLAPLYWLGGGPQSLIVAQAVLFALAAIPIWHYAERRIGTVPAHLVAVAYAVSWPIAQAAGFDFHEAAFVPLLSATMIERFDARRPLLGVLAAAGLLLVKEDMGLLLAGFGVYLVVTRRRLEGAAFILFSLGALVVIRSALMPLAGASTTGFHWAYGNWGATLGEVAVAILRDPLGALAQSVSPMVKVNTLAFLLWPMALTALLSPLTLVAVPLVAERFLADRPQWWGPEHHYNAFIVAILVCAGVDGAARLAKRFPGRGVATHWAVAVCLIGLTLVPRFELGKLLDPGYYDGEPHIAAAREAVTMVPDGVIVEASNNVGPALTARTTVLLWGPQAHDAPWIVADVARWSYPFGDFGMQQRRVDEALANGYRKVFDRDGYIVLNRPS
>NC_013595.1|WP_012887800.1|1071484_1072630_+|acetyl-CoA-C-acetyltransferase
MAEAYIVGAVRTPVGKKKGGLSTVHPTDLAAHTLKALIDRTGVDPSAVEDVIMGCVMQFGPQSMDIARNAWLSAGLPESVAGVTIDRQCGSSQQSIHFAAQGVLSGTQDLVVAAGVESMSIVPMGSSITAALEKGMPFPFGDMWVERYGKQEISQFRGAELMCEKWDLSREELERFAYESHQRAAKAIANGYFKDQIAPVNGVEDDEGPRADSTLEKMASLKTLRDGGRITAATSSQISDGSGALLIASEQAVRDHGLTPRARIVTLALTGDDPVYMLTAPIPATQKALKRSGLSIDDIDVTEINEAFAPVPLAWIKDLGADPAKVNPNGGAIALGHPLGGTGAILMTKLLHELERTGGRYGLQTMCEGGGQANVTIIERL
>NC_013595.1|WP_012887801.1|1072683_1072857_-|hypothetical-protein
MRIHAGQKPDDNSKTPKPRTPLPERNLPPAAPRHMPKPHMPMRPTQQPRRIPGKGGR
>NC_013595.1|WP_012887802.1|1073116_1074991_-|acyl-CoA-dehydrogenase-family-protein
MTDYAKAREVAEQAREKEWARPSFGRQLFLGNFRLDLVHPAPGMSEADAKKGEDFLRALRRFLDTRVDPALIERTAQVPDEVVKGLAELGAFGITIGEEYGGLGLSHLDYGRALMLVGSYCPALSTLLSAHQSIGVPQPLKEFGTEEQKRRFLPRCAKGEVSAFLLTEPDVGSDPARLATTAVRDGDDYLLDGVKLWTTNGVVADLLVVMARTGTKISAFVVEADTPGITVERRNAFMGLRGIENGVTRFHRVRVPAANLIGREGQGLKIALTTLNTGRLSLPAVCAGNAKWAVKIAREWGDARVQWGRRIGEHEAVARKIAFIAGTAYALEAVMDLSCRLADEESNDIRIEAALAKLYASEMAWQVADELVQIRGGRGYETAESLAARGERGVPAEQVLRDMRINRIFEGSTEIMQLLIAREAVDAHLTVAGELIDRSLDGRAKARAAVKAGGFYARWLPTLVAGTGNRPGSYAEFGALARHLRYVERTSRKLARATFYGMSRWQGRLEHKQGFLGRIVDIGAELFAITATCVRAREDEAELGRRPAEIADTFCHQARLRVDALFDRLWDNSDARDVRLARHVLRGRYTFLEEGILDASIDGPWIAATAPGPSATGNAHRSIR
>NC_013595.1|WP_012887803.1|1075188_1075920_-|methyltransferase
MSGYDRVVQPAAGDEALENHLGGDEAKNYRQYELDMVAPHVGRSMLEIGSGLGHFAEAFLPRLDRLVVSDFDPYCVDRLRKRFAGRDEIDVLQFGLPTDIPIGEKVDTVVMMNVLEHIEEDVEALRSLAKVTLPGGRIVIWVPGYMQLYGDFDRKVGHVTRYTPATLRSTVSKAGLDIDVLKPINFLGGIAWWAAVRRGGVGYPDPRLVKIYDRTVVPTTRFIERFIRPPFGQTVFCVARVPK
>NC_013595.1|WP_169369258.1|1076050_1078075_+|hypothetical-protein
METTFVGRRVEIAQVVRLIRESRLVTLTGLGGVGKTRLAGRAAEEIAGEFPDGLWLVELACLTDPHLLAETVADSMGLADQSARQQEEVLADWLSPRRSLLMLDTCEHLVEAVASLVDTLLRRAPGLRVLATGRQPLGVSGEHIYLVPPLPVEDAVALLRDRAGLARDAGDAGDADGAGTAGDGAEGMAALCEGLDCIPLAIELAAVQLRTMPPALLTPQLHDRYRLLTGGDGPMRHESLRAAMGWSHELCTPAERLLWARLSVFAAGFDLEAAERVCAGGPLPSGLVLETLTGLVDKSLVQREDHPAGVRLRMLDTVREFGAEWLLLLGETGAVRDRHRDHYLRLARRCAAEWPGRQVEWYGRIRAEQRNFRKAFELCLADPEWSRTGLDLAGTLWFLWVCCGMLREGRHYLETALGMDTRPGPERIRALWVCAWVAALQGDLDGAWERLDRCRAEDPGGSAAGYAIQIEGLISLMRGDYPRAVELLDEAMAWHMAEGDVLSGLLPCYTLAALSLLAAGRPEETMETLSEGQALCEAHGEEWSRAQMEYVFAWAEHVKGGTSGALRHARAALTAARLFDDLLLSVVCVEMIAWAVAVEGAAGRAARLLGAAQAVWDSSGLSQFGSPIFIPIRRRAVNQAVRALGGGEFDTLFAEGHRLDLGIAVKYALEEKIS

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Crispr_ID: NC_013595_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_9

1257557-1257678

Orphan

Consensus_repeat	Method
CCGCGTAAGGCGGCGCGTGCTCCGGTGACGGCGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_9

>merge|NC_013595|9|1257557-1257678|CRISPRCasFinder
CCGCGTAAGGCGGCGCGTGCTCCGGTGACGGCGTGCCGGCGGGGAACGCCGTGCCTGCTGACGGCGTGCCGGCAGGGAGCGGCGTGTCCGCGTACGGCGGCGCGTGCTCCGGTGACGGCGTG

>NC_013595|9|9|1257557-1257678|CRISPRCasFinder
CCGCGTAAGGCGGCGCGTGCTCCGGTGACGGCGTG	CCGGCGGGGAACGCCGTGCCTGCTGACGGCGTGCCGGCAGGGAGCGGCGTGT
CCGCGTACGGCGGCGCGTGCTCCGGTGACGGCGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012887978.1\|1264781_1265501_-\|PIG-L-family-deacetylase	unknown	unknown	gnl\|CDD\|225031
NC_013595.1\|WP_012887969.1\|1256545_1256755_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012887964.1\|1253622_1254048_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|377770
NC_013595.1\|WP_012887965.1\|1254044_1254236_-\|ferredoxin	unknown	unknown	gnl\|CDD\|224064
NC_013595.1\|WP_012887972.1\|1259822_1260461_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_013595.1\|WP_012887973.1\|1260499_1261969_+\|glutamate--cysteine-ligase	unknown	unknown	unknown
NC_013595.1\|WP_012887966.1\|1254235_1255180_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|274926
NC_013595.1\|WP_012887967.1\|1255184_1255628_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NC_013595.1\|WP_043651439.1\|1267962_1268868_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012887971.1\|1258552_1259767_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|226951
NC_013595.1\|WP_148269468.1\|1263222_1264038_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_013595.1\|WP_012887975.1\|1262813_1263077_+\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NC_013595.1\|WP_012887961.1\|1249603_1250494_-\|xanthine-dehydrogenase-family-protein-subunit-M	unknown	unknown	gnl\|CDD\|224238
NC_013595.1\|WP_012887962.1\|1250490_1253034_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	unknown	unknown	gnl\|CDD\|224446
NC_013595.1\|WP_148268965.1\|1262052_1262712_+\|neutral-zinc-metallopeptidase	unknown	unknown	gnl\|CDD\|225203
NC_013595.1\|WP_012887977.1\|1263991_1264732_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|377092
NC_013595.1\|WP_012887968.1\|1255924_1256500_-\|ABATE-domain-containing-protein	unknown	unknown	gnl\|CDD\|227803
NC_013595.1\|WP_012887963.1\|1253030_1253528_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NC_013595.1\|WP_169369262.1\|1255720_1255879_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043651437.1\|1265650_1267876_+\|DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|273429

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012887978.1\|1264781_1265501_-\|PIG-L-family-deacetylase	gnl\|CDD\|225031	COG2120, COG2120, Uncharacterized proteins, LmbE homologs [Function unknown].	2.83964e-43
NC_013595.1\|WP_012887964.1\|1253622_1254048_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|377770	pfam07080, DUF1348, Protein of unknown function (DUF1348). This family consists of several highly conserved hypothetical proteins of around 150 residues in length. The function of this family is unknown.	6.65911e-89
NC_013595.1\|WP_012887965.1\|1254044_1254236_-\|ferredoxin	gnl\|CDD\|224064	COG1141, Fer, Ferredoxin [Energy production and conversion].	3.76376e-12
NC_013595.1\|WP_012887972.1\|1259822_1260461_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	8.31325e-66
NC_013595.1\|WP_012887966.1\|1254235_1255180_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|274926	TIGR04025, hypothetical_protein, PPOX class probable FMN-dependent enzyme, DR_2398 family. Members of the PPOX family (see pfam01243) may contain either FMN or F420 as cofactor. This subfamily consists of proteins mostly from species that lack the capability to synthesize F420, and therefore most likely all bind FMN.	9.15549e-11
NC_013595.1\|WP_012887963.1\|1253030_1253528_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	6.9478e-76
NC_013595.1\|WP_012887971.1\|1258552_1259767_+\|ATP-binding-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.08306e-25
NC_013595.1\|WP_148269468.1\|1263222_1264038_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	4.63163e-07
NC_013595.1\|WP_012887975.1\|1262813_1263077_+\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	8.6059e-23
NC_013595.1\|WP_012887977.1\|1263991_1264732_-\|ABC-transporter-permease	gnl\|CDD\|377092	pfam03649, UPF0014, Uncharacterized protein family (UPF0014).	1.69075e-47
NC_013595.1\|WP_012887962.1\|1250490_1253034_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	0
NC_013595.1\|WP_148268965.1\|1262052_1262712_+\|neutral-zinc-metallopeptidase	gnl\|CDD\|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	3.34328e-17
NC_013595.1\|WP_012887968.1\|1255924_1256500_-\|ABATE-domain-containing-protein	gnl\|CDD\|227803	COG5516, COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only].	2.75525e-13
NC_013595.1\|WP_012887967.1\|1255184_1255628_-\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	3.56556e-17
NC_013595.1\|WP_012887961.1\|1249603_1250494_-\|xanthine-dehydrogenase-family-protein-subunit-M	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	2.82157e-72
NC_013595.1\|WP_043651437.1\|1265650_1267876_+\|DNA-helicase-PcrA	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0

>NC_013595.1|WP_012887969.1|1256545_1256755_-|hypothetical-protein
MRPEIDRTTERGRRHRTDWMALLSGVLFIAVGIVFISRPGIEPVIMIPVVLGGLGFAGLVAILVRAVRR
>NC_013595.1|WP_012887968.1|1255924_1256500_-|ABATE-domain-containing-protein
MLVLEFVSTIRATRSGLLDTLSDVEGMTEWGRAHAAGLGLTAGFTATEDLRREVVELRQAVRALFARAVAPGPVSSADADRLPDFAESLDLVNAAALAAPLAPRLDWPAEGAPVATSVPAGERAESPRIRAALATSVIELLAGPAREQLRACPAPRCVLYFVKEHARQEWCSIGCGNRARAARHYRQHKGR
>NC_013595.1|WP_169369262.1|1255720_1255879_+|hypothetical-protein
MIRVTLRGRQGDPVRPSARRSARTAAVGRTGRAGMREPAVRLRGHAVRLVRR
>NC_013595.1|WP_012887967.1|1255184_1255628_-|VOC-family-protein
MTFQTGHVGLNVSDLDRSKDFYLKIFGFEVFGESAEADRRYAFLGADGKLLLTLWQQSEGRFATGTPGLHHLSFQVPDIETVHRAETVIRELGATLHHDGVVPHGEGASSGGVFFEDPDGIRLEIFAPSGADERPAPTGAAPTCGFF
>NC_013595.1|WP_012887966.1|1254235_1255180_-|pyridoxamine-5'-phosphate-oxidase-family-protein
MRHAGELAVQRRAGVRAGAWGSASARPEIPAAAAEFLARQRMLLIGAGDRDGRLWASALTGAAGFAEAVDERTIVIDAVLGEHDPLAGLTGGEIGILAIEPRTRRRMRVNGTVRRDGGRLTVHAEQTYANCPKYIQRRDISDEPATGSPATASATGTLTAGHRAWIESADTFFVATRAPGLGADLSHRGGNPGFVRVTGGGRLVWPDYAGNSMYMTLGNLELDESCGLLFLGWESGEALHLTGRARVGWDPGDVPGAQRLVEFEVDQAVHVRGASPLRWTFDGYSRFNPPVHPAHAEAPAGAAHTTEPGREGGQ
>NC_013595.1|WP_012887965.1|1254044_1254236_-|ferredoxin
MRVIVDRVLCQVHAQCVFAAPEVFELDDDDQLVYVAEPDDGLIDAVEEAARACPVQAIFLEEA
>NC_013595.1|WP_012887964.1|1253622_1254048_-|nuclear-transport-factor-2-family-protein
MNFTEETARAKVQAAEDAWNTRDPERVSLAYTPDSVWRNRDEFVTGREEIREFLTRKWAREREYALRKDLWTFGGNRIAVRFQYEWHDADGQWWRSYGNELWEFADDGLMRRREASINDVRIDEADRRILGDCTPKELPLA
>NC_013595.1|WP_012887963.1|1253030_1253528_-|(2Fe-2S)-binding-protein
MPRITVTVDGVTYEEEVEPRLLLVHLLRDRLGKTGTPVGCDTSNCGACTVMLDGRSAKSCSVLAVQADGSDVVTIEGLAQGDEWHPMQKAFHTEHALQCGYCTPGMIMAAIDLLRDDPDPSEEAVREGLEGNLCRCTGYCNIVRAVRRAAQEMSQAGERREVRTP
>NC_013595.1|WP_012887962.1|1250490_1253034_-|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit
MSEQLDAGVLAEQIAESDQLGEPSGTHEVGRARRRKEDARLVTGRTTWTDNIQLPGMLYMAFLRSPMAHARITRVDTSAARARPGVVAVYSGRDLAGEQGSLPCAWPVTEDIVIPDHPPMAVDEVRYAGEAVACVVATDRYKAADALEAIEVDYEPLDAVIDMTEALAEGAPRVHESGNRAFTWKFAGGDIDAAFRDAPVVIERTYVQQRLIPSAMEPRAVVATTDGDGFTLYSATQIPHVLRVMLALTTGIPEHKLRVVAPDVGGGFGSKLQVTAEEVLGLLVTRRLGKPVKWTESRSEGNLTVHHGRDQLQRISLAAERDGRVRGVRVDLLADMGAYLMLVTPGIPLLGAFMYNGIYKIDAYDFTCTGVFTTKMPTDAYRGAGRPEATFAIERAVDELAHELGLDPVEVRRRNWITHQEFPYDTICGLTYDSGNYEAATEKALALFGYDKLRAEQSDRRDRRDPVQLGIGVSTYTEMCGLAPSRVLGSLSYGAGGWEHASVRMLPTGKVEVVTGTSPHGQGHETAWSQIVADALGVPFGDVAVLHGDTAISHKGMDTYGSRSLVVGGVAVLAACEKVKDKARQIAAHMLEASADDIEFSAGSFTVRGTAEGKTIQELALATFAAHDLPDGVEPGLDADATFDPDNFSFPHGTHLCAVEVDTETGACAIRSYVAVDDVGSVVNPLIVEGQVHGGIAQGIGQALFEEAVHDAEGNLLTTTMADYLIPTAADLPGFTTDRTETPATSNPLGVKGVGEAGTIASTPAVVNAIVDALRPYGVHDVRMPCTPERIWRVVSEAGPPASGSGSRSASAEAPAETSAGASADAPASTPGPGSGEATSSSEGGAR
>NC_013595.1|WP_012887961.1|1249603_1250494_-|xanthine-dehydrogenase-family-protein-subunit-M
MIPAAFDYIRPTSLEEACRVLAEADSAGDDVKVLAGGQSLLPLLRLRLAYPAALVDLGRLPEPRGVEDRGDHVFVGALTTHDEVLRSGVVREQVPLLALATATVADPAVRHRGTFGGSMVHADPAGDLPAVALALDCVFVVRSSEGEREIPADEFFVDYLESALGPGEVLLGVQVPKLGPGWGFHYEKFHRTAQAWAIVGVAAAVRRDGGTIGEARIALTNMGPTPVRARVTEAALRGLSPAPAGGAGDGARDQVRDACGQADSGTSPPADLHAKPDYRRHLARVLTYRAVRAASG
>NC_013595.1|WP_012887971.1|1258552_1259767_+|ATP-binding-protein
MADRQTTRDAAPATPEEPALPRLIRPVDGRLVAGVAQGAAAQLRLDPVALRLAFVLLTVLDGIGAVAYAALWMFTPREPYEGREPSRDWSQVAAYGAIGLALMALGWLTGASTGGIGAWPIAVGGIGSLILWQQADPDRRQRWMNSTVGQVRRNRVRTLAGLALVVVGAIGFLVVTEELGSAQPGIMFTLVVVGGVALIAAPWLAALWKELQRERRERIRQEERAEFAAHVHDSVLHTLTLIQRNANDSREVMRLARSQERELRNWLYQPKQDADASVAAAVRRVAAEEEDAHGVPIEVVCVGDCPLTPALSAMMQAARQAMVNAAKYSESSVVSVYAEAEPEEVTIFIRDRGVGFDMGQVPEDRMGIRQSIIGRMERHGGSARLRTEPGEGTEVMLTMKLEKT
>NC_013595.1|WP_012887972.1|1259822_1260461_+|response-regulator-transcription-factor
MSTIRVLIVDDHRLFRSGVRAELGDSIEVVGEAEDVESAVRTIAELQPDVVLLDVHMPGGGGQEVLRRVLGSGSSVRFLALSVSDAAEDVIGVIRGGARGYVTKTISGRELTDAIRRVADGDAVFSPRLAGFVLDAFASSEAPPIDPELDSLTQREREVLRLIARGYAYKEIAKELFISVKTVETHVSSVLRKLQLSNRHELSRWATARRLV
>NC_013595.1|WP_012887973.1|1260499_1261969_+|glutamate--cysteine-ligase
MGRDVPAMVFSREDRRRYRDKVRRCLDVFAQMLREARFECERPKAGLEIELNLVDDRGDPAMKNAEVLAAIAEPDWATELGQFNVEINVLPESLEGDGPVRLEKVVRDRLNHAENRAHTVGGHLVMVGILPTLRESDVHEGTLSANPRYKLLNEQIFEARGEDLHLAIDGEETLDTYADSITPEAACTSLQLHLQVSPAAFAAHWNAAQAIAGAQVAVAANSPFLFGRQLWQETRIPLFEQATDTRPVELKTQGVRPRVWFGERWITSVFDLFEENARYFPALLPICEDADPREELTRGVTPALDELTLHNGTVYRWNRPVYAVVDDIPHLRVENRVLPAGPSVADVAANAAFYYGLMRVLPHAERPVWTRMSFAAAGDNLHSAARHGLDARLYWPGLGEVAAAELILRRLLPLAYEGLDLWGVNPEPRDRLLGIIEQRCVTGRTGATWQIDTVKELGNLDRREALRRMTLRYIEHMHTNEPVHTWPSP
>NC_013595.1|WP_148268965.1|1262052_1262712_+|neutral-zinc-metallopeptidase
MRGMKAFRCLLLLLMVTVAACGSDRAGTGAAGPAPLGQTFESDIRLAKELSEAYWRQVFSADGLAYRPVTAFTAYRGEDGPGCGGRPSVPNNAFYCADGHFIAYDESWMRKLYDEMGDGSVYVIIPHEFGHAVQAQLNSGFRLNVERELQADCYAGGTLGALVEGGSLEAEPGDKDELLLNLAAAGDPTDDWLRPDAHGTAEQRQALFAKGYNEGTAAC
>NC_013595.1|WP_012887975.1|1262813_1263077_+|WhiB-family-transcriptional-regulator
MRRKVREIGWAIRGACRASDPDLFFPLAQSAEQEARAKAVCAGCPVLADCRAYAVRAGEPEGIWGGLTVQERRRLRFPSGWRQPAAG
>NC_013595.1|WP_148269468.1|1263222_1264038_+|CPBP-family-intramembrane-metalloprotease
MLAGAVAVLAAANVVNNRVAPRLAPLTSAAATCALLALARRSGLSWSELGFHRGPPGLRIGGTLASAVAGVYAVGIAVPATRRFFRDERALSLSRARALEEALLQVPVGTVLLEEVGFRGVLHALLTRSHGPRTATAVSSALFGLWHVLPAIDMMAANPALSGLAAGEPPGDGPLEEDRRGEDGAAQDPPARASRWEAARVVAGSVAATGLAGVFFCELRRRGGLAAPSLLHVATNSLGYLFARLAPADPGSGGGRLTGSRGTGPEPPARS
>NC_013595.1|WP_012887977.1|1263991_1264732_-|ABC-transporter-permease
MSPVDLSPVTAVAVALLALAGAAVALLGRLGHARAVLTACLRAAVQLGAVSLIIVWAVGRPLAVAAFVLVMYGVASLTAGRRITSGRAVRWAAVPIAVGTLPVLALLVGTGTVPLKGITLIPVAGILLGGCLTVTALAGRRAVDELVQRRGEVEAALALGFSERDAALEICRPAAAQALVPALDQTSTVGLVTLPGAFVGMLLGGASPLQAGVVQLVVLVALLAAEAAAVLVTIELAARGRFRASR
>NC_013595.1|WP_012887978.1|1264781_1265501_-|PIG-L-family-deacetylase
MLSENEINRVLVVTAHPDDVDFAAAGSIAQFTDRGVEVTYCIVTDGDAGGFDRELDNGGMAELRRTEQTNAAKIVGVTDLRFLGYHDGTVVQSLDLRRDITRVIRQVRPDLVITHTPERNYGFIAPSHPDHRAVGGSALDAVYPDARNPYTFPSLLLEEGLEAWTVREVWLNGGQTPDHHVDITGTFERKLSALRAHVSQTSHMEGFDDFLRTRFSQVAAEAGLGEGRYAEAFQRVPTA
>NC_013595.1|WP_043651437.1|1265650_1267876_+|DNA-helicase-PcrA
MLDGLNPQQREAVVHHGSPLLIVAGAGSGKTRVLTHRIAYLLGERGAQPQEILAITFTNKAAREMKDRVDNLIGPRSAAMWVMTFHSACVRILRREAKRLGFPSSFSIYDQADSQRLMAMVCREMDLDPKRYPPRSFSAQVSNFKNELIDYETAAGQASSHLERTLAEAYRNYQRKLTEAGAMDFDDLIMLTVTLFQIFPDVAEHYRRRWRHVMVDEYQDTNHAQYTLIRELVGAPELRTADGDLVREGTIAPAELCVVGDADQSIYAFRGATIRNILEFERDYPNAKTILLEQNYRSTQTILSAANAVISRNESRKPKNLWSDQGAGPKIVGYVADNEHDEAMFVAQEVDKLTDDEGVVPGQVAVFYRTNAASRVFEEIFIRTGLPYKVVGGVRFYERKEVRDLLAYLRVLANPNDVVSLRRILNVPKRGIGDRAEAMVEAFASRERIPFWEGLRRADEAPGMATRSLNAIREFVALMEELMAKAAGTPPSELAQEVLESTGYRTELATSGDPQDESRLENLDEMISVASEFEEANPEGTLVEFLEQVSLVADADQIPAGDGGQGVVTLMTLHTAKGLEFPVVFLTGMEDGVFPHMRSLGEPKELEEERRLAYVGITRAEKRLYVSRAAVRSSWGAPAFNPASRFVAEIPGELVDWRGDPGKNAWSAGTSRRETRPAPARKPGGKPIPNLSPGDRVTHDQFGLGTVVSVDGVAEKTKAKIDFGSGGEKTLLLAYASLEKL
>NC_013595.1|WP_043651439.1|1267962_1268868_-|hypothetical-protein
MIATLTGATAAALIAPALVAAAAPANAQPAQASVQTAQADPVSALKSQFKLHRGVKLAENAKIIGEGENQRSIFNRRGGVLEFGRSGVVASDVTDKFTLPGADKELKNLFGPSRTITVKDTTYTSGGFYADSMPEGKKWLRAKGGAVVVGNPAQQILNPLEPATLKAALAHTATRRPGGTWDGARTVVHSGTITLGELYKVSPTVRALLGGKPSAASATLPVSWKLYLGPDQLVRRAVSSWTQSLRGLTSLDMTYLNDSRYSGWGTRSAIKAPPASQVADFDDLDLGEEQTEDPFVRVFKD

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Crispr_ID: NC_013595_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_10

1322450-1322510

Orphan

Consensus_repeat	Method
GCGGAGCCGGAGACGCGGAGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_10

>merge|NC_013595|10|1322450-1322510|CRISPRCasFinder
GCGGAGCCGGAGACGCGGAGCCGAGGGCGTGGTGATGCGGAGACGCGGTGATGCGGAGCCG

>NC_013595|10|10|1322450-1322510|CRISPRCasFinder
GCGGAGCCGGAGACGCGGAGCCG	AGGGCGTGGTGATGC
GGAGACGCGGTGATGCGGAGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012888032.1\|1330709_1331156_+\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|223149
NC_013595.1\|WP_043654861.1\|1322604_1323057_-\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|372719
NC_013595.1\|WP_012888031.1\|1328151_1330449_+\|alpha-xylosidase	unknown	unknown	gnl\|CDD\|236731
NC_013595.1\|WP_012888034.1\|1331577_1332477_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_013595.1\|WP_174435281.1\|1332473_1333337_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226666
NC_013595.1\|WP_012888037.1\|1335395_1336601_+\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NC_013595.1\|WP_012888024.1\|1318099_1319527_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|367293
NC_013595.1\|WP_012888020.1\|1315046_1315673_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012888017.1\|1311294_1312575_+\|thymidine-phosphorylase	unknown	unknown	gnl\|CDD\|180276
NC_013595.1\|WP_012888033.1\|1331245_1331557_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133394
NC_013595.1\|WP_148269469.1\|1313336_1314761_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_013595.1\|WP_012888021.1\|1315694_1316051_+\|cupin	unknown	unknown	gnl\|CDD\|369571
NC_013595.1\|WP_012888028.1\|1323201_1324596_+\|NAD(P)H-quinone-dehydrogenase	unknown	unknown	gnl\|CDD\|236112
NC_013595.1\|WP_012888026.1\|1321494_1322298_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NC_013595.1\|WP_043651460.1\|1333488_1335159_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270298
NC_013595.1\|WP_012888025.1\|1319684_1321328_-\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NC_013595.1\|WP_148268967.1\|1312802_1313249_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_013595.1\|WP_012888022.1\|1316280_1317360_+\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480
NC_013595.1\|WP_012888029.1\|1324543_1325782_-\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NC_013595.1\|WP_012888023.1\|1317386_1318058_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012888033.1\|1331245_1331557_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133394	cd04766, HTH_HspR, Helix-Turn-Helix DNA binding domain of the HspR transcription regulator. Helix-turn-helix (HTH) transcription regulator HspR, N-terminal domain. Heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	6.94497e-13
NC_013595.1\|WP_043654861.1\|1322604_1323057_-\|gamma-glutamylcyclotransferase	gnl\|CDD\|372719	pfam13772, AIG2_2, AIG2-like family. This family is found in bacteria and metazoa.	2.49678e-25
NC_013595.1\|WP_012888031.1\|1328151_1330449_+\|alpha-xylosidase	gnl\|CDD\|236731	PRK10658, PRK10658, putative alpha-glucosidase; Provisional.	0
NC_013595.1\|WP_012888034.1\|1331577_1332477_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.60376e-61
NC_013595.1\|WP_012888037.1\|1335395_1336601_+\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	2.67466e-59
NC_013595.1\|WP_012888024.1\|1318099_1319527_-\|ATP-binding-protein	gnl\|CDD\|367293	pfam03008, DUF234, Archaea bacterial proteins of unknown function.	7.15912e-11
NC_013595.1\|WP_012888032.1\|1330709_1331156_+\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	3.49831e-25
NC_013595.1\|WP_012888017.1\|1311294_1312575_+\|thymidine-phosphorylase	gnl\|CDD\|180276	PRK05820, deoA, thymidine phosphorylase; Reviewed.	0
NC_013595.1\|WP_174435281.1\|1332473_1333337_-\|ABC-transporter-permease-subunit	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	1.21122e-95
NC_013595.1\|WP_148269469.1\|1313336_1314761_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.30605e-48
NC_013595.1\|WP_012888021.1\|1315694_1316051_+\|cupin	gnl\|CDD\|369571	pfam07883, Cupin_2, Cupin domain. This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).	0.00262953
NC_013595.1\|WP_012888028.1\|1323201_1324596_+\|NAD(P)H-quinone-dehydrogenase	gnl\|CDD\|236112	PRK07845, PRK07845, flavoprotein disulfide reductase; Reviewed.	0
NC_013595.1\|WP_012888026.1\|1321494_1322298_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	1.72626e-114
NC_013595.1\|WP_043651460.1\|1333488_1335159_-\|extracellular-solute-binding-protein	gnl\|CDD\|270298	cd13580, PBP2_AlgQ_like_1, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	2.12007e-43
NC_013595.1\|WP_012888025.1\|1319684_1321328_-\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NC_013595.1\|WP_148268967.1\|1312802_1313249_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	9.64812e-14
NC_013595.1\|WP_012888022.1\|1316280_1317360_+\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	7.71468e-166
NC_013595.1\|WP_012888029.1\|1324543_1325782_-\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	1.47227e-29

>NC_013595.1|WP_012888026.1|1321494_1322298_-|purine-nucleoside-phosphorylase
MSNDPYALATEAATALKSATGVDAFDVALVMGSGWVPAADAIGETISEIPVTDLPGFAPPAVAGHAGRVRAVRTESGKVALIFLGRTHLYEGRGVDPVVHGVRTAIRAGAGTIVLTNAAGGLRPETQEVGEAVLISDHINLTGANPITGATFVDLTDVYTPRLRDLVREIEPSMAEGVYVAFRGPTYETPAEVRMCRILGGDMVGMSTVLEAVAAREGGADVLGISLVTNPGAGLVGEPLNHEEVLEVGRATAARMGGLLAKVVGKL
>NC_013595.1|WP_012888025.1|1319684_1321328_-|phospho-sugar-mutase
MSSDLVRLARSWLAQDPDPETRAELTALLDGGDADALRERFGAKLEFGTAGLRGELGAGPNRMNRVTVMRAAAGLARVLGPGRHVVIGYDARHKSDVFAHDTAAVLTGAGLRASVLPRPLPTPVLAFAVRHLGADAGVTVTASHNPPRDNGYKVYWNDGSQIVPPVDSEISAAIDAVGQVSGLPLGSPDDPAWATLGDDVVAAYLEAVTALPLGGARGLRVAYTPLHGVGGATLAGAFRAAGFEVPATVEAQAAPDPDFPTVAFPNPEEPGAMDLALELARSVGADIVLANDPDADRCAVGVPLPEGGYRMLTGDEVGALLGEHVIRQTSGDGRLVATTIVSSSLLGKIASGHGVRYAETLTGFKWIMKAGDGLVFGYEEALGYSVGADSGLPVHDKDGIGAALTVAGLAAQAKLDGRNLLDLLDDQARRYGLHATSQLSVRVDDLSLITGAMARLRATPPVKLGGREVESADDLSEGSAGLPPTDGLRYRLSGGARVVVRPSGTEPKLKCYLEVVVPVTGEVSDARAQAVQDLDALKADLSAALGL
>NC_013595.1|WP_012888024.1|1318099_1319527_-|ATP-binding-protein
MDGFIGRAHELGKLRRLLNKVEAGGRVGRPGRAILVRGRRRVGKSRLAEEFIRCSGVPHLFYSAARGPEGQQLQRFLSAGAASDLPGAQLMAGQSPDSWDAALRLLVAALPQDSPSIVVLDELPYLIASSPDLESVLQVLFDREFSHRPVLLILIGSDLSMMEAINRYDRPFYMRATEMVVRPLTPADVAEKLELPPADAFDAHLVSGGLPMICEEWQPGLSVQEYLQEALTDSTSSLVISGERALAAELPPDAQARTVLSAIGSGQRTHASIDRATPGIPRASLNRALQFLVEKRLVVPELPLSTRPSRETRYHIADTHLRFWLTFVGPWLPEIERDRGDLVLDRFHRSWTSWRGTAVEPVIRESLRRMDGLPEETCAIGGYWTRTNDPEIDIVGADREPIAKKITMVGSIKWLENRPFDRHDLSELIVHRSRLPGADTSSPLFAVSRSGVTAEGVEEITPERLLDAWRPPPGA
>NC_013595.1|WP_012888023.1|1317386_1318058_+|hypothetical-protein
MKQVFRSRTALVLGWIWMAFAAFNAVDLIVRYSGPSSLVAAAVLGVLTALVFIACLRPAVILTEDGVLVRNPLRNASVPLAGVDEVVVSHSIKITSGGESVRCWTPQTSARERAAAVRRGTSANTGSRHKTEPTRSKGEQAAAEALAGKTHADWVAEQITERAEAAKRAAVRNAGRVTAESADGTGTRAAESAGPAAMKVTWAPSALAALLAAAVLVIAAILA
>NC_013595.1|WP_012888022.1|1316280_1317360_+|adenosine-deaminase
MSQLPTLEEIRRAPKVLLHDHLDGGLRPETIVELAAGSGYDRLPTTDVDGLRTWFREASDSGSLERYLETFDHTVGVMQTRESLVRVAAECAEDLAADGVVYAEVRYAPEQHTSAGLSLEEVIEAVQEGFRAGSEGRGIRVGTLLTAMRHQARSREIAELAVRYRDVGVAGFDIAGAEAGYPPTRHLDAFEYLQRENAHFTIHAGEAFGLPSIWQAIQWCGADRLGHGVRIIDDITVSGEGEAKLGRLAAYVRDKRIPLEMCPTSNLQTGAATSIAEHPIGLLRRLNFRVTVNTDNRLMSGTSVSEEFAKLSEAFGYGWDDMQWFTINAMKSAFLPFDERLALINGVIKPGFARLKWQA
>NC_013595.1|WP_012888021.1|1315694_1316051_+|cupin
MVRKIDSATRIPVPGGKMIDEYVGRVNSDDSRISIAHMKAPAGWDEPAQRPEFGEYTLVLKGTVVVEHEGGTTEVNAGQAFVSEPGEKIRYSCGPEGAEYVAVCLPAFSPDSVNRDDG
>NC_013595.1|WP_012888020.1|1315046_1315673_+|hypothetical-protein
MNRIVVPRTLVPLALVPLALLAGCGSVTQSATPSSATPGAAVTASAPISSPPVSSPSVSSKAGLKPPTSTKEIEVEHAVDEPPTVTGVRFAEHGGFDRVVIDLKGGLPGYSVRWVPELVQDGSGEPIDVRGGAYLQVSMHPAGAHTQSGSPTWTGGPIFQAALGNVRNVVKTGDFEAVVGVGIVLDHKAAFRVIEQKKPDRLVIDVAH
>NC_013595.1|WP_148269469.1|1313336_1314761_+|MFS-transporter
MIPSSNDGRWDARLWAALTVLCAVVFLDALDVSMVGVALPSIQADLGLSTSSLQWVVSGYVLGYGGLLLLGGRTADLLGRRRVFLVALAVFAVASLLGGLVSDGTLLIAARFVKGISAAFTAPAALSIITTTFAEGPARNRALSIFTASGASGFSLGLVISGFLTELGWRWTFLMPVPVAIIALVAALKFLPKRREERAEGGYDLIGATTITGSMLLLVFAVVEAPEVGWGSVRTIATLAAAVALLVVFVLAEQRVKHPLVRLGILRSGPIVRANLGLVILFGSYVGFQFVAMQYFQNFLHWSALETALAFLPAGLLVAVTSTKMGSLADRFGTARLIVIGSAALAAGYAFFLRLDGAPSLATLIIPGMVLLGIAFALSFPSLNIQATNGVADDEQGLASGLLNTSGQVGGAVVLAVVTAVLTSTTSADPIDGFRAAITVSGILGLVGLVIALTGLRRPRTAVAIEDEKVLETV
>NC_013595.1|WP_148268967.1|1312802_1313249_-|MarR-family-transcriptional-regulator
MSEEYAVRAWRDVLAKHAAAACALERELSERHQLGMSEFEVLERMVEGGRERYRVQEVADAVHLSQSACSRLIARLEKSGLVCRGMCEDDRRGVFVLITDEGRERHAAALSTHRTVLADIFEPGQPTRSGQPTRCEQSTRSGRAAAQA
>NC_013595.1|WP_012888017.1|1311294_1312575_+|thymidine-phosphorylase
MDAIDVIVTKRDGRELSVEQIDWVIDAYTKGVVADEQMSSLAMAILLNGMTRREIGEWTQAMIRSGARMDWSALPGRTTDKHSTGGVGDKITLPLAPLVAACGGYVPQLSGRGLGHTGGTLDKLESIPGWRASLSNQEMLDVLGEAGAVICAAGDGLAPADKKLYALRDVTGTVESIPLIASSIMSKKIAEGTGALVLDVKVGSGAFMKTVERARELATTMVELGTDAGVETVALLTAMDRPLGRAVGNALEVAESVEVLAGGGPDDVVELTVRLAREMLQAAGLSGGKDPEQALKDGSAMDVWRRMISAQGGDPDALLPKAAETLEITAPSSGVLAGLDAYGVGLAAWRLGAGRERKEDPVSFGAGIMLHARPGDLVREGQPLMTLHADETSRFERALAALEGAYVIGETADPGLLPLVIDRITA
>NC_013595.1|WP_043654861.1|1322604_1323057_-|gamma-glutamylcyclotransferase
MPVYAAYGSNMDPKQMAQRAPHSPMRGSGWLQGWRLTFGGNDLGWEGALASIVEDPDEHVFVVLYDVPEWDETSLDQWEGAARGLYHKVRLRVQTLEGEVVAWFYVLDGYEGGLPSARYLGILAEAAEHAGAPDDYVKDLRSRPCKSLGS
>NC_013595.1|WP_012888028.1|1323201_1324596_+|NAD(P)H-quinone-dehydrogenase
MTRIVIIGGGPGGYEAALVAAQLGAQVTVVEQDGPGGACVLTDCVPSKTLIATSVRKQALLDASMLGVHYTGGPDGDAGGVIADMPLVNKRVKELAQAQSADIAVRLAAEGVEVVRAAGRLVDPQVVRAGDRTIRADVVIVATGATPRILPSAEPDGERILTWRQIYDLEELPEHLIVVGSGVTGAEFAGAYRSLGSEVTLVSSRDRMMPNEDADAAEVLEEVYRRRGMNVMGRSRAESVKRTADGVVVTLEDGRTAEGSHCLMTVGMIPNTAGLGLEEAGVTLDRGGFIQVDKVSRTSAPGVYAAGDCTGVLMLASVAAMQGRIAVWHALGEAVQPLRLATVASNIFTDPEIAAVGVAQKAIEAGEIEANVVKLPLATNARAKMQGFNDGFVKLFCRPHTGIILGGVVVAPRASELILAVSVAVQQRLTVDQLAHTFAVYPSMSGSITEAARRLMQPMTPSGI
>NC_013595.1|WP_012888029.1|1324543_1325782_-|pentapeptide-repeat-containing-protein
MRRSVPLALTVAIFALSGTMLSPAQAGAGPCRPGQGPDLRGRDFTRGASLPADLRCANLTKAKLRGVELVQKDLTGAVLRGADLRQANLTQAVLKYADLRGANLGEADLGQMHADHADARGANLIDAEAGQAQFPHADLTGATLTRAELTQVNFTNAKLIDADLNESTPGQIKARKADFTRAKLREAKLGQANLRNATFKDADLSEAELTQAELDGAVFTGALVEGASFVQADDADLAGAKGTPKGLSLPTTDLLIPDGIFTPEKETDQLAEPAGTAGAPSVGLVMVVVSAIGLAVTVVAWGISTQRRNRRNSRFALMRHGAEEDITRLGEEIDQLDYEFQVGGHGDITGDQDWRHAIDAYEAAKNALALARREEELHFVADAVQAGRNALGRLRVRSRWGSSAASDGGPPR
>NC_013595.1|WP_012888031.1|1328151_1330449_+|alpha-xylosidase
MPYRPPLIAHEYFVADPPELPVRSHGETGLSALTSAELVAAEAAGVTLKAVTSAGETLVVQVGVVGEGVIRVRLGQDVDARTRSAAAISMVTPGVFAGARVEAGDGTILLDAGPLRAEITLAPWHLRFTDAAGATLLEQDPGHTDISGRLRTLPFGRSSRDGAVAGYHESFAAPADEAFTGFGESFTPLDKRGQRPVMWNFDAFGAESQRAYKNVPFYLSSRGYGVLVDSGTPVEFDVCQSTHSTVQIVVPDDLIDYYVIAGPTPPEVLDRFDLLTCRPALPPKWAFGTWISSGFFVDTQERVMARARRIRERGIPCDVLHLDTYWQTDGHWSDLRWDAANFPDPEGMLAELDGMGFKVCLWMNPYISHLSPAFPQAAQDGYFLKKADGEVYVADCWHGSYPPCGIVDFTNPAAVEWFQRLLRPLLEQGVQVFKTDFAEAVPHDAVAANGMTGADLHNVYTLLFNDAVSEVTREVAGHGMVWARSSFLGGQRHSAQWSGDTYTSYPAMGSTLRGGLAHGLSGIPFWSHDAGGFTGRPTDDLYVRWTQFGALSPLLRLHGTTSREPWEFPEVEAEAVEALRLRYRLMPYLYTAAVEAARTGAPMMRALCVDHPDDPVAWQADLEYLLGRDLLVAPMTSPDGVRKVYLPAGGWVDHWTGEVLAGGRYVTVSMPLDRIPLFVRHGALIPVLAEPGEAVGDGPFGEITLIGYGVGESRTTVSDLDGDTTITAVPDGDGLRVTVSGSARIAGVELVGVGVPVVVTTVRET
>NC_013595.1|WP_012888032.1|1330709_1331156_+|Hsp20/alpha-crystallin-family-protein
MLLTSIDPFVQEFDRQFDRLTRQALGWGQNDTRGAMPLDGVRRKDDVLLKFDLPGADPDSVEVTVDRGVLSVSARREEEYGQDDRLFVRERPMGAFTRRVYLSEHLDSEKIDAAYSNGVLAVRIPVIEKAKPRKVEIHKADEVKSIKA
>NC_013595.1|WP_012888033.1|1331245_1331557_+|MerR-family-transcriptional-regulator
MMVRLPFDDEHAPLYSVGQVAGMLHVEQAFLRRLDEHDVVRPARSSGGQRRYTRHEIGDLQNAIQLVGEGMTLAAVRRIFELQHQVRELQEELARERATRRED
>NC_013595.1|WP_012888034.1|1331577_1332477_-|carbohydrate-ABC-transporter-permease
MTTSPAWAERPSRVGGLIKGAVLTLIVACVLFPIYMVVLTSLSTQEAVSEAGGLVTVPGELSLAAYAELFSGGVVTRSVLVSLGVTVVGTALSLSVTVLAAYGLSRPGSLMHKPMLFLILLTFLFGPGIIPNYLLVSSLGLIDTYWSLILPGVVTAFNLVVMRAFFMNIPEEIGDSARIDGASEFGILMKIVLPMSKGVTAVIGLFYAVGYWNSFFNAVLYLNDNAKWPLQVVLRQYVLQGQSLFVGQTGDSTIAGQALPPSLAIQMAIVVVALLPVLFVYPFVQRHFTKGVIIGAVKG
>NC_013595.1|WP_174435281.1|1332473_1333337_-|ABC-transporter-permease-subunit
MALPAVGLLIVFHYVPLLGNVIAFQDYSPYVGIADSPWAGLSNFHWLLFDESMWDATLNTLSITTFQLIFYFPVPIMLAVLLDSVVRPRLRLFIQGIVYLPHFFSWVLVVTLFQQMFGGAGLLSQTLREHGYDGFDLMTNPDTFIALVTAETIWKDAGWGTIIFLAALAAINQNLYEAAAVDGASRWRRLWHITLPGLRPVIILLLILRLGEALNVGFEQFFLQRDAVGRDAAEVLDTFIYWRTLLTGEWSYGAAAGLVKGLVGLVLILIANKVAHRFGEQGIYKRS
>NC_013595.1|WP_043651460.1|1333488_1335159_-|extracellular-solute-binding-protein
MTSRRGFLGLVGLSAAAVAGGGLLGGCSAPSSPRPGSGGATAAAADKLTSLTPTYAAFPGVKPDLPGTVSTLPGVPDVSGGFTSYPAAPAAALPRKAGRGGTYKAMTPLWGPPPPGLADNSYFQAVNADIGATVEFQITDGTVYGDKTIARLAAGDVPDIMVIPSWEIDKMADFNTAVDKAFEDLTPYLQGDKVKPYPLLANLPTAAWQWSVWNDKLMAVPFPTEPYPFGLLYRKDLFDKNGWNANPKSADELYQLGKEITDPKAKRWAFGSIHEMMWPTFRVPQDWRYESGKLVHKYETPEFEQMLAFMQKVFKEGLVHPNVTSSKGANEKDLIGAGQILVYRDGLGGWKELLQQHRGKNPDFAIGVFPVFAHDGGKPLMYHGTAAGIFTFVKKGLPKEKVEEILSILNWTAAPFGTKEYELATFGVEGKHFTRGGNGIPEPTDLGRKEVAYTYGFLGGRPLYVDWSYPDAVKLNLEWQNATFPFIEKAPFDGIRIQRPSKYSGLQIPTEDKFTDIMRGRRPIGDVKQIVTEWRRDGGDEARDFYMKVLRDNGRA
>NC_013595.1|WP_012888037.1|1335395_1336601_+|ROK-family-transcriptional-regulator
MITSTTDPQPADFADVRATNLAVVLRFVREHAPCSRADIAASTGLNKATVSSLVADLIDRRLVRETGLTENRVGRPATMLVLDGSPYAAIGVEVNVDYVTAVAVDLSGERLLSWRRSFSGATITAAQAVATVAAIVRRVVNRMAKEERQVLGLAVGVPGLVGTDGTVRIAPNLGWRDADLCGDLTKALRDPGFPVQVDNDANLAALAEHRFGPRAGTANLVYLTGEIGVGAGVVLDGRLRRGGQGYGGEIGHIQLDPLGAECRCGRLGCLEAVAGIGAVLEHAALSPAEVEIELDEVVRLARAADPRILAVLATVGHNLGKGVAVIANLLNPEVVILGGYYVPLAPWLLPAVEAELRGRTIAPDAGGCQVVASTLGYGAAALGGAARVLDSVDSGRLPRIS

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Crispr_ID: NC_013595_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_11

1389491-1389590

Orphan

Consensus_repeat	Method
CACCCCTCGCCGCGCTTTTGACTTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_11

>merge|NC_013595|11|1389491-1389590|CRISPRCasFinder
CACCCCTCGCCGCGCTTTTGACTTTCTACCCCGGTGCGGCCTGTACGGAAGGAGTGGTCCTTGGCCGCTCCACTCACCCCTCGCTGCGCTTTTGACTTTC

>NC_013595|11|11|1389491-1389590|CRISPRCasFinder
CACCCCTCGCCGCGCTTTTGACTTTC	TACCCCGGTGCGGCCTGTACGGAAGGAGTGGTCCTTGGCCGCTCCACT
CACCCCTCGCTGCGCTTTTGACTTTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012888080.1\|1385821_1387429_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NC_013595.1\|WP_012888082.1\|1388382_1389003_+\|DUF1062-domain-containing-protein	unknown	unknown	gnl\|CDD\|368855
NC_013595.1\|WP_012888074.1\|1380463_1381741_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_013595.1\|WP_012888076.1\|1382591_1383536_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043651490.1\|1395018_1395375_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_013595.1\|WP_012888083.1\|1389937_1390570_+\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|273358
NC_013595.1\|WP_012888077.1\|1383587_1384730_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	unknown	unknown	gnl\|CDD\|235674
NC_013595.1\|WP_012888085.1\|1392390_1393554_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NC_013595.1\|WP_012888072.1\|1379059_1379542_+\|bacterioferritin	unknown	unknown	gnl\|CDD\|153099
NC_013595.1\|WP_148268970.1\|1401396_1403127_+\|CDP-alcohol-phosphatidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|223632
NC_013595.1\|WP_012888089.1\|1397009_1398041_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133016
NC_013595.1\|WP_148268969.1\|1393809_1394301_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_081453045.1\|1378864_1379044_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|377304
NC_013595.1\|WP_012888078.1\|1384797_1385301_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl\|CDD\|376377
NC_013595.1\|WP_012888091.1\|1399945_1401358_-\|bifunctional-cytidylyltransferase/SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|133009
NC_013595.1\|WP_012888084.1\|1390925_1392245_-\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NC_013595.1\|WP_012888073.1\|1379791_1380460_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_013595.1\|WP_012888088.1\|1395426_1396944_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|224235
NC_013595.1\|WP_012888075.1\|1381819_1382482_-\|GtrA-family-protein	unknown	unknown	gnl\|CDD\|377229
NC_013595.1\|WP_148269475.1\|1398068_1399871_-\|CDP-glycerol-glycerophosphotransferase-family-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012888080.1\|1385821_1387429_+\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	8.58455e-33
NC_013595.1\|WP_012888082.1\|1388382_1389003_+\|DUF1062-domain-containing-protein	gnl\|CDD\|368855	pfam06353, DUF1062, Protein of unknown function (DUF1062). This family consists of several hypothetical bacterial proteins of unknown function.	1.8625e-41
NC_013595.1\|WP_012888074.1\|1380463_1381741_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.79665e-34
NC_013595.1\|WP_043651490.1\|1395018_1395375_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	9.15809e-23
NC_013595.1\|WP_012888083.1\|1389937_1390570_+\|LysE-family-translocator	gnl\|CDD\|273358	TIGR00949, Uncharacterized_membrane_protein_YahN, The Resistance to Homoserine/Threonine (RhtB) Family protein. [Transport and binding proteins, Amino acids, peptides and amines].	9.76305e-34
NC_013595.1\|WP_012888077.1\|1383587_1384730_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	gnl\|CDD\|235674	PRK06019, PRK06019, phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed.	6.1279e-171
NC_013595.1\|WP_012888085.1\|1392390_1393554_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0
NC_013595.1\|WP_012888072.1\|1379059_1379542_+\|bacterioferritin	gnl\|CDD\|153099	cd00907, Bacterioferritin, Bacterioferritin, ferritin-like diiron-binding domain. Bacterioferritins, also known as cytochrome b1, are members of a broad superfamily of ferritin-like diiron-carboxylate proteins. Similar to ferritin in architecture, Bfr forms an oligomer of 24 subunits that assembles to form a hollow sphere with 432 symmetry. Up to 12 heme cofactor groups (iron protoporphyrin IX or coproporphyrin III) are bound between dimer pairs. The role of the heme is unknown, although it may be involved in mediating iron-core reduction and iron release. Each subunit is composed of a four-helix bundle which carries a diiron ferroxidase center; it is here that initial oxidation of ferrous iron by molecular oxygen occurs, facilitating the detoxification of iron, protection against dioxygen and radical products, and storage of ferric-hydroxyphosphate at the core. Some bacterioferritins are composed of two subunit types, one conferring heme-binding ability (alpha) and the other (beta) bestowing ferroxidase activity.	6.59411e-77
NC_013595.1\|WP_148268970.1\|1401396_1403127_+\|CDP-alcohol-phosphatidyltransferase-family-protein	gnl\|CDD\|223632	COG0558, PgsA, Phosphatidylglycerophosphate synthase [Lipid metabolism].	1.73303e-11
NC_013595.1\|WP_012888089.1\|1397009_1398041_+\|glycosyltransferase	gnl\|CDD\|133016	cd02525, Succinoglycan_BP_ExoA, ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.	3.6377e-97
NC_013595.1\|WP_081453045.1\|1378864_1379044_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|377304	pfam04324, Fer2_BFD, BFD-like [2Fe-2S] binding domain. The two Fe ions are each coordinated by two conserved cysteine residues. This domain occurs alone in small proteins such as Bacterioferritin-associated ferredoxin (BFD). The function of BFD is not known, but it may may be a general redox and/or regulatory component involved in the iron storage or mobilisation functions of bacterioferritin in bacteria. This domain is also found in nitrate reductase proteins in association with Nitrite and sulphite reductase 4Fe-4S domain (pfam01077), Nitrite/Sulfite reductase ferredoxin-like half domain (pfam03460) and Pyridine nucleotide-disulphide oxidoreductase (pfam00070). It is also found in NifU nitrogen fixation proteins, in association with NifU-like N terminal domain (pfam01592) and NifU-like domain (pfam01106).	4.41859e-11
NC_013595.1\|WP_012888078.1\|1384797_1385301_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl\|CDD\|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	5.84407e-86
NC_013595.1\|WP_012888091.1\|1399945_1401358_-\|bifunctional-cytidylyltransferase/SDR-family-oxidoreductase	gnl\|CDD\|133009	cd02516, CDP-ME_synthetase, CDP-ME synthetase is involved in mevalonate-independent isoprenoid production. 4-diphosphocytidyl-2-methyl-D-erythritol synthase (CDP-ME), also called 2C-methyl-d-erythritol 4-phosphate cytidylyltransferase catalyzes the third step in the alternative (non-mevalonate) pathway of Isopentenyl diphosphate (IPP) biosynthesis: the formation of 4-diphosphocytidyl-2C-methyl-D-erythritol from CTP and 2C-methyl-D-erythritol 4-phosphate. This mevalonate independent pathway that utilizes pyruvate and glyceraldehydes 3-phosphate as starting materials for production of IPP occurs in a variety of bacteria, archaea and plant cells, but is absent in mammals. Thus, CDP-ME synthetase is an attractive targets for the structure-based design of selective antibacterial, herbicidal and antimalarial drugs.	1.13868e-71
NC_013595.1\|WP_012888084.1\|1390925_1392245_-\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NC_013595.1\|WP_012888073.1\|1379791_1380460_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	8.30013e-84
NC_013595.1\|WP_012888088.1\|1395426_1396944_-\|LCP-family-protein	gnl\|CDD\|224235	COG1316, LytR, Transcriptional regulator [Transcription].	4.51778e-56
NC_013595.1\|WP_012888075.1\|1381819_1382482_-\|GtrA-family-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	4.5148e-28

>NC_013595.1|WP_012888082.1|1388382_1389003_+|DUF1062-domain-containing-protein
MSSQPHRDHVVLPWIVQRTRLPLLSLRCLECRATVATTGEGRFRVNANGKLLDVWLLVRCVACGQTSKVTVHERAPVRSFDPVQLHAFETNDSASVAQTLLDPLVARRNRFTLKWNGAWRLVTPQEPPADASWPVQVKVEFLDPVPVRPEQLIAQGLGISRSETGRRIKCDIPLNRRTSTDFVFTVHPDPQGIFAVHPDPQGRCEV
>NC_013595.1|WP_012888080.1|1385821_1387429_+|OmpA-family-protein
MVRKPASLAAVTMATVMLTSCGLTGVPQGGGGEERQFGPAAASPTGSAPTSQPAPGATATASSPTGAGADTRPALASTQSTHTPAYKVEVVGLNRVAGKHLVVQLRLSNTGTSENISWTGELGDNTRPLGEIRWASGIGVLDAAARRWLLPYKPADSPCLCSDERRDDLGYFIEPGESLPVYAVLPAPSGNPATTTVVTPLGPPMMDVPISDEPVTPPAGQTFPDPEAQPVTVISHRIMTPSESPDRSEETTDDGEDLHVNLSSDVLFALNRADLTPRSRAVLTRTAKLIDTSEGATITVEGHADSSGTDAINDPLSQRRAQAVQRALSGLLTRTGVRFQAKGYGSRRPLYGNEDEEGRRRNRRVTVTFAKPRPAETRPATTPEADPAPSGRGLTARGKDDGQPFTLEVTSLRRLPGDLGVLTYKITNDGDAEAWHHELNRSAEWMSYKYQAAGNVRLTDPATRRQYLPGRIVVQADDGTDAYCACTELAGVRVGTEKIAPGRTKEFWSLFALPAGASSAQVKIAQYPPLRVPIR
>NC_013595.1|WP_012888078.1|1384797_1385301_+|5-(carboxyamino)imidazole-ribonucleotide-mutase
MTTVGIVMGSDSDWPVMRLAAEALAEFGVEFEADVVSAHRMPEEMIAYGAQAAGRGLKVIIAGAGGAAHLPGMLASVTPLPVIGVPVPLKYLDGMDSLLSIVQMPAGVPVATVAVGGARNAGLLAVRILAAADEDLRARMVEFQASLKEQAHAKGAKLRAEAAQLGG
>NC_013595.1|WP_012888077.1|1383587_1384730_+|5-(carboxyamino)imidazole-ribonucleotide-synthase
MASPIGPVVGVIGAGQLARMMQQAAIALGVELRVLANSPDESAARVIVDVRLGDYRNLADLRDFAKGCDALTFDHEHVPTEHIRALAGDGSAVHPGADALVHAQDKAVMRERLTAIGVPCPPWRRIATAADVEEFAADNGWPVVLKAVRGGYDGRGVWICRSAEDAAEVLASGVPLMAEAFVPFERELAVLVARSPHGQGVSYPVVETVQRDGICVEVIAPAPGLDPEQAAAAQRIALTIAHELGVSGLLAVEMFATASGLVVNELAMRPHNSGHWTIDGARTSQFEQHLRAVLDLPLGSPSLTAPVVVMANLLGGDDPDVFSRYEHVMAHDPGIKVHFYGKEVRPGRKIGHVTALGTDLDEVRARARHAAVYLTEGVYT
>NC_013595.1|WP_012888076.1|1382591_1383536_+|hypothetical-protein
MPRRLLALLLGLSVTTGCGARAAGQDTPREPGASPRTSVRAVEPAEAAQAFKLLGRLDDAWRKRDCQTVERLTTWAEKTLGGRACEATRNGRPAPSRKGYSDAEFFLPATAGADRWFVALARRPHPAYFLFVHEGDDWRLAAGPVPVKGEPREPAGGAVPADDPGAGVGARLAPQRYLTYLTDPAGVSGVTFPKGDIARELFDELVRRPRKVRPDRLTSDVRLLVGPQRALLLPGGGALVIHALEIEHRQRAGPGRSSLRHPIYGKDELRGFTGKGRVAGLTGTEIVLVVTEVTGGTGVSTVAARRSLATLTTG
>NC_013595.1|WP_012888075.1|1381819_1382482_-|GtrA-family-protein
MPGFIRQGVTFIEIFLADWYAQHLVNRQAEPGTPPVAWQKNVRGPPEWRIPSQPGKDRAGDVQFLRGAYERLSGLIRELSKFGTIGAIAFVIDTGGFNLLQYGLHWGTLTSKVIATVIATTFAYFGNRFWTYRHREQSGLAREYFLFFLLNGVALLIGLLCIGFTRYTLELTDPLSINVANLIGIGLGTLFRFWSYKKWVFLAATEEVPKELPDEVTRAR
>NC_013595.1|WP_012888074.1|1380463_1381741_+|HAMP-domain-containing-histidine-kinase
MRRRLLSSTLLVAVIGVLLLGIPLGVAVNRLIEEEATQELSSQAKSLLGEVEYARIQDQPIDPEQLKRKYPDRYIQIYAKGTPPQVTTVGDEPPENHKMTQDAQSENGVYVAVSRDKTEVEREVRAWLLLILALAAAALAVAVGLAIVQSRRLTLPLSDLAMIAERLGSGDARPSKHRYGIQELDRVAEVLDRSATRISDLLAREREFATDASHQLRTPLTGLTMRLEEIVAAAHEPGIVKEEGEAAIVQAERLTAVIDELLAAARRQRHAQTEVVELDDLLDQQFIEWGPVFRRGGRQLKLSGTRGLQAVGTSGGISQVISTLLENSLEHGDGTVTVTTSDKDRSVLVEVADEGEGIPEDLAPRVFERNVSGAGGTGLGLTLARALAAADGGRLELVRPRPAAFALFLRQVGDPGRKRVVSGPA
>NC_013595.1|WP_012888073.1|1379791_1380460_+|response-regulator-transcription-factor
MTCVLLAEDDTSISEPLARALRREGYQVEVSPDGPQALERALSGGIDLIVLDLGLPEMDGLEVARRIRAEGHGTPVLILTARVDEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRGTSETPVVQGVRIDADSRRAWMGDKELHLTTKEFDLLRVLVRDAGKVVTREQIMREVWDTNWWGSTKTLDMHISWLRRKLGDDAAKPRYITTVRGVGFRFERE
>NC_013595.1|WP_012888072.1|1379059_1379542_+|bacterioferritin
MQGDKKIIELLNEQLTAELTAINQYFLHAKMQENWGYTRLAKYTREESIDEMRHAEKLTDRILFLEGLPNYQKLGILHIGQTVKEQLRADLDVELEVVTRLRPAIILMREKGDATSARIFEEILEDEERHIDYLETELGLIESLGEQLYLARYAEPPSAS
>NC_013595.1|WP_081453045.1|1378864_1379044_+|(2Fe-2S)-binding-protein
MYVCVCRAVTENEVHDCIAGGAKSARQVRDITGAGGDCASCVRKICAILKRSEDLLPTA
>NC_013595.1|WP_012888083.1|1389937_1390570_+|LysE-family-translocator
MTSLPQVLAFGGVVMLGAMSPGPDFAVVVRRSAVSGRNLGMATAVGIAAGVFAWAAAAATGLAALVAASAMAFTIVKMVGAAYLLYLGVRALIGAVRGGGAEPDAPEAGRGSPWAAFREGLLCNVLNPKAALFFVALMPQFLSDGAPLGDTLMLSAVALVITTAWFLTVANLVGALRRILARPAARRTIDALSGAALIALGVRLAAVSRP
>NC_013595.1|WP_012888084.1|1390925_1392245_-|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MAYRLTMVGTGYLGATTSACMAELGFEVLGVDVDAEKIARLQAGDLPIYEPGLQEVLRRNLANGRLRFTTSYEEAAAFGDVHFLCLGTPQKPGEYGADVSYLDAAIESLAPHLKRECLVLGKSTVPVGTAQRLADKLARLAPIGSGAELAWNPEFLREGFAVKDTLYPDRIVLGVASDKAEKVMREVYASMLEMGTPIVITDYPTAELVKVAANAFLATKISFINAMAEVCEASHADVKQLSLALSFDDRIGGKFLNPGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDAINMRRRARMVDLARELAGGSFRGCTVTVLGAAFKPNSDDIRDSPALDVAVKISEQGGRVTVYDPVAQENARRAHPELSYGESALEAARDAHVVLLLTEWQEFIDLDPDTLGTVVATRKIVDGRNALDAETWRASGWHYRALGRP
>NC_013595.1|WP_012888085.1|1392390_1393554_+|acyl-CoA-dehydrogenase-family-protein
MSFPLYALPEEHDMLRETVRALADEKIAPRAAEADETGEFPWDVYKALVAADMHAVHVPEEYGGAGADALATVIVIEEVARACASSSLIPAVNKLGTVPLLLSASEEVKQRYLAPVARGEAMFSYALSEAEAGSDAAAMKTRAVADGDHYVLNGAKMWITNAGVSEYYTVMAVTEPGAGARGISAFVVEKSDEGVSFGPKERKLGIKGSPTRQVILENVRIPASRMIGEPGTGFKTALATLDHTRITIAAQALGIAQGALDYAVGYVKERKQFGKAVAEFQGVQFMIADMAMKLEAARQLTYAAAAKSELAMHGEPQKDLTFFSSAAKCAASDAAMEITTDAVQLLGGYGYTGDYPVERMMRDAKITQIYEGTNQIQRMVMARQLLK
>NC_013595.1|WP_148268969.1|1393809_1394301_-|hypothetical-protein
MMLVGTLCTAFAGGVDAVKGARSLFGKPAPGSEASVTEPVAANATPWSPCQVMRGSARLQAGKTLVAAVRQPYDKKARYHFELIEVGDDGAWTVVLPLDPGDPAAGGRTYKITLLDADSRWVAHVIDAAGGGSETSWKARATPPRSSSLISFSILRSLGTGNC
>NC_013595.1|WP_043651490.1|1395018_1395375_-|STAS-domain-containing-protein
MIVIPAFDVQRWNNGPCVIVRAAGELDMAVAPRLRAEVDRALETPGHPCLVMDLTEVPFCDSVGLGILVGALTRIRDTHGRLILVVGPGMITHLLTITNLNRHFETCGSLREALDAAA
>NC_013595.1|WP_012888088.1|1395426_1396944_-|LCP-family-protein
MRDPEEDDSGVQVGGDAYGTVRVTPVNPRRDRRSVRGARSRRRGLFVAGALSCLVLGSSGVTWALTNYAEKKIEAVDAGVPGSQSTGAMNILVVGVDRRDNLSRQQQNRLKLGRESGERTDTMMVLHLSEDHTRATVVSLPRDTWTTVPGKGAHKINAAYQLGGPKLAVRTVQNATGLTIHHYVEVNVLGFIEVVDALGGVSVCTPVAINDPKTALTLQPGTYSLDGVKALAYARTRATARSDLDRIDRQQQVISALLHQALSGDTLTNPVRLASFVDTALGTLRVDDALRKDLLGLANQLKDVSTDDVAFATVPLADVDYKTPTNESAVLWDKEASKELFRRIAADEPLTKPAKSTATPAPASSATPSPSATAPTVPPSRISVKVLNGTLITGLGARTRADLLKAGFLVPEIAGDTRKRDHDKTVIRYGKGREDSARTLAAALPGSDTRLVEDLGDRIEVIAGRKYQGVKKVTVDDAVKPTATPSPAQSALPTARTATQNICKK
>NC_013595.1|WP_012888089.1|1397009_1398041_+|glycosyltransferase
MKQFPDSPAPASSPETRVWPPISIVIPVLNEERHLREAVRQVLAQRYAGPIEVVLAIGPSRDRTQEVADAIAAEDPRVTVVPNPTGRTPNALNAAIGASRNGIIARVDGHAMLPEDYLQVAVETLEETGADNVGGVMAAEGVTPFEQAVARAMTSKIGVGGARFHTGGTAGPADTVYLGVFRREALERVGGYDEHFQRAQDWEMNHRIRETGGLVWFQPRMRVSYRPRPTVKALAEQYFHYGRWRRVVARTHEGTINLRYLAPPVAVLAILAGLVLSPFFWPGLLIPGGYLAAILAGSAVTGSGLPTASLVRLPLVYVTMHMSWGWGFLTSPKRLSKSGRTRG
>NC_013595.1|WP_148269475.1|1398068_1399871_-|CDP-glycerol-glycerophosphotransferase-family-protein
MACAVLAGSYPLLVIAALWPLPWLFLVACALSYAAEIVARRRARRVIDLLSKVRLGVTLRFMMRETAAILLVARTAGTDSPWFTLLVLGLFTLHGARALQTWLAITYSRVLNQLPVLTRNIDGVVRLPPPPSAILVDHGSMRMLHLDMLPVGGAALGAVLGTGHQGAAGAVVAVGLGAAGAVGLLPHLRRIQPLKNRRGMLKAVNRRLARYRPEVILYFSGPNDSAYQVTMWLRPLERIDRRAVVVLRERNMLRLLGETSLPVVCIPSAADLMSFGALDSARVCLYPSNVGKNIHMLRIRGMRSVFVGHGDSDKEASFNPFTKVYDEVWVAGQAGRDRYLRARVGVCDEDVHEVGRPQLTGVHTTGPGLPYRTVLYAPTWEGWTDDLFHTSIITMGPSIVRALLAHSPALRVIYKPHPLTGYRNLAARRAHEEILTILEEAELSRSIARHPAGAVRTDPIGHRAVTGSEPHLYDCFNQADLMVTDISSVVADFIASGKPYVVTNVAGLPERAFRERYPSTEAGYLLTRDLGELPAVLAALEQDGEDVLAATRRKLKAYLLGPDHPDAMARFNDAVNASYGRAARGADTAGTGVAAARGEG
>NC_013595.1|WP_012888091.1|1399945_1401358_-|bifunctional-cytidylyltransferase/SDR-family-oxidoreductase
MAALEPRLRTVGVVLAGGVGQRVGLNTPKQLVKIAGKTILEHTLALFDGAPEVDEIIVMMTPGFTEEVERIVALNGFRKVSKILEGGASRPDTTWRALKALGAQECDVLLHDAVRPLLEPRIITECVEALKVYSAVDVAIPSSDTIVVAAPGPRGEIVRDIPERSRLRRGQTPQCFRLSVIREAYERAFADPGFDRQPPTDDCGVVLRYLPDVPIYIVPGSEHNMKVTHPVDVFIADKLFQLAAGAAPEHSPFAYREAMEGRTMVVFGGSYGIGADVVDLAERHGAEVFSFSRSLNGVRVEDPQAVEDALAHAAKETGRIDYVVNTAGVLHMGKLGEVNDTTIAETVGVNYLGPVNIARAAIGHLRETQGHLLLYTSSSYTRGRADYSLYSSTKAAVVNLTQALADEWAEYGVRVNCVNPERTSTPMRVRAFGEEPAHTLLSPRAVAQTSLDVLISHLTGHVIDVRLDGT
>NC_013595.1|WP_148268970.1|1401396_1403127_+|CDP-alcohol-phosphatidyltransferase-family-protein
MGAYPIAGRAPVLSRQDLATLSTHSPIRTVIPSDTKEPGLHDSHALAPSGARRTAAVVLATMEAAALRCADGTLLDRLTDQLVRLPVGDVHVVARSSEIIHAPGGTYMIGSEGSRGLADDLRRVAAVARTSTAPVAVVAGDLVAHTEALAMLLEHPARDTGALVTRGAEDAGPSRPPVRTEGGRVVAAGTSFHDVVDANGTFRGVLQVGAADLADLAETAETLAELAEAGGFGQMGGAEAGDLLLVGLVRAGVPVRACGIGRLHCDRVAGQEGADAAVLRLGEVDEDRARLEVAVKSDDGFFATHFVSSWSTHLVKLAADLHLTPNAVTGISVGLAALAAVWFTAGTREAQIAGAVLLYLSFVLDCVDGQLARYTRAFSPLGAWLDATFDRVKEYAVYVGLAIGYAAGMDDSRGGPHGIWVLAVAAMILQMLRHMIDFSYAGARADAGRSKAAGAVTAASLTAPADASMGAVPRRTPLEQSAEVADGIAAAERYLRERQGPGSGNAVVRLSRRLERISFTRWLKKIIVLPIGERMALIAVTAAVFNARVTFIALLVWGGVAALYTVAGRIGRSFSR

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Crispr_ID: NC_013595_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_12

1479772-1479873

Orphan

Consensus_repeat	Method
CTTGTGGCCGGCGGGTCCGGGGTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_12

>merge|NC_013595|12|1479772-1479873|CRISPRCasFinder
CCGGTGACCGGCGGACCCGGTGATCAGCGGGCCACGATCTTGTGGCCGGCGGGTCCGGGGTTCAGCGGGGCCTGGGCCTGGTGGCCGGCGGGTCCGGGGTTC

>NC_013595|12|12|1479772-1479873|CRISPRCasFinder
CCGGTGACCGGCGGACCCGGTGATC	AGCGGGCCACGATCTTGTGGCCGGCGGGTCCGGGGTTCAGCGGGGCCTGGGC
CTGGTGGCCGGCGGGTCCGGGGTTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012888152.1\|1473422_1475162_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_013595.1\|WP_012888166.1\|1490675_1491122_+\|PTS-glucose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|376324
NC_013595.1\|WP_081453394.1\|1468196_1469201_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NC_013595.1\|WP_012888164.1\|1489299_1490334_+\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223526
NC_013595.1\|WP_012888161.1\|1485468_1486803_-\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273923
NC_013595.1\|WP_012888159.1\|1481712_1484520_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NC_013595.1\|WP_012888165.1\|1490386_1490623_+\|PTS-glucose/sucrose-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|273923
NC_013595.1\|WP_012888150.1\|1471087_1472374_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372351
NC_013595.1\|WP_012888148.1\|1469274_1470435_-\|DUF4350-domain-containing-protein	unknown	unknown	gnl\|CDD\|379527
NC_013595.1\|WP_012888157.1\|1479933_1481115_-\|YcaQ-family-DNA-glycosylase	unknown	unknown	gnl\|CDD\|225755
NC_013595.1\|WP_012888162.1\|1487021_1488362_-\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273923
NC_013595.1\|WP_012888151.1\|1472717_1473395_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_013595.1\|WP_012888153.1\|1475175_1476939_+\|GerMN-domain-containing-protein	unknown	unknown	gnl\|CDD\|237447
NC_013595.1\|WP_043651510.1\|1477041_1477746_+\|phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223970
NC_013595.1\|WP_012888155.1\|1478269_1478926_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|129824
NC_013595.1\|WP_148269480.1\|1470431_1470965_-\|DUF4129-domain-containing-protein	unknown	unknown	gnl\|CDD\|379261
NC_013595.1\|WP_012888156.1\|1479021_1479726_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_013595.1\|WP_012888158.1\|1481205_1481460_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367689
NC_013595.1\|WP_012888163.1\|1488398_1489139_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_013595.1\|WP_012888160.1\|1484597_1485107_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012888152.1\|1473422_1475162_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.5879e-54
NC_013595.1\|WP_012888166.1\|1490675_1491122_+\|PTS-glucose-transporter-subunit-IIA	gnl\|CDD\|376324	pfam00358, PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1.	9.14936e-46
NC_013595.1\|WP_081453394.1\|1468196_1469201_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	3.33249e-104
NC_013595.1\|WP_012888164.1\|1489299_1490334_+\|SIS-domain-containing-protein	gnl\|CDD\|223526	COG0449, GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane].	9.15517e-68
NC_013595.1\|WP_012888161.1\|1485468_1486803_-\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273923	TIGR02002, PTS_system_glucose-specific_IIABC_component, PTS system, glucose-specific IIBC component. This model represents the combined B and C domains of the PTS transport system enzyme II specific for glucose transport. Many of the genes in this family also include an A domain as part of the same polypeptide and thus should be given the name "PTS system, glucose-specific IIABC component" while the B. subtilus enzyme also contains an enzyme III domain which appears to act independently of the enzyme II domains. This family is most closely related to the N-acetylglucosamine-specific PTS enzymes (TIGR01998). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	3.12911e-123
NC_013595.1\|WP_012888159.1\|1481712_1484520_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NC_013595.1\|WP_012888165.1\|1490386_1490623_+\|PTS-glucose/sucrose-transporter-subunit-IIB	gnl\|CDD\|273923	TIGR02002, PTS_system_glucose-specific_IIABC_component, PTS system, glucose-specific IIBC component. This model represents the combined B and C domains of the PTS transport system enzyme II specific for glucose transport. Many of the genes in this family also include an A domain as part of the same polypeptide and thus should be given the name "PTS system, glucose-specific IIABC component" while the B. subtilus enzyme also contains an enzyme III domain which appears to act independently of the enzyme II domains. This family is most closely related to the N-acetylglucosamine-specific PTS enzymes (TIGR01998). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	2.12055e-20
NC_013595.1\|WP_012888150.1\|1471087_1472374_-\|hypothetical-protein	gnl\|CDD\|372351	pfam12868, DUF3824, Domain of unknwon function (DUF3824). This is a repeating domain found in fungal proteins. It is proline-rich, and the function is not known.	2.08603e-06
NC_013595.1\|WP_012888148.1\|1469274_1470435_-\|DUF4350-domain-containing-protein	gnl\|CDD\|379527	pfam14258, DUF4350, Domain of unknown function (DUF4350). This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length.	4.07415e-05
NC_013595.1\|WP_012888157.1\|1479933_1481115_-\|YcaQ-family-DNA-glycosylase	gnl\|CDD\|225755	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown].	3.65826e-76
NC_013595.1\|WP_012888151.1\|1472717_1473395_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.34677e-87
NC_013595.1\|WP_012888153.1\|1475175_1476939_+\|GerMN-domain-containing-protein	gnl\|CDD\|237447	PRK13613, PRK13613, lipoprotein LpqB; Provisional.	1.49934e-76
NC_013595.1\|WP_043651510.1\|1477041_1477746_+\|phosphoribosyltransferase	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	4.34666e-34
NC_013595.1\|WP_012888155.1\|1478269_1478926_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|129824	TIGR00741, Probable_sigma54_modulation_protein_ORF3_ORF95., ribosomal subunit interface protein. This model includes a small protein encoded by one of two genes, both downstream of the gene rpoN for sigma 54, whose deletion leads to increased expression from sigma 54-dependent promoters. It also includes the N-terminal half of a light-repressed protein LtrA of Synechococcus PCC 7002 and the N-terminal region (after removal of the transit peptide) of a larger plastid-specific ribosomal protein of spinach. The member of this family from E. coli is now recognized as a protein at the interace between ribosomal large and small subunits, with about 1/3 as many copies per cell as the number of ribosomes. [Protein synthesis, Translation factors].	1.38902e-25
NC_013595.1\|WP_148269480.1\|1470431_1470965_-\|DUF4129-domain-containing-protein	gnl\|CDD\|379261	pfam13559, DUF4129, Domain of unknown function (DUF4129). This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif.	4.34194e-05
NC_013595.1\|WP_012888156.1\|1479021_1479726_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.93599e-77
NC_013595.1\|WP_012888158.1\|1481205_1481460_-\|hypothetical-protein	gnl\|CDD\|367689	pfam03839, Sec62, Translocation protein Sec62.	0.00270527
NC_013595.1\|WP_012888163.1\|1488398_1489139_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	7.7339e-78
NC_013595.1\|WP_012888162.1\|1487021_1488362_-\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273923	TIGR02002, PTS_system_glucose-specific_IIABC_component, PTS system, glucose-specific IIBC component. This model represents the combined B and C domains of the PTS transport system enzyme II specific for glucose transport. Many of the genes in this family also include an A domain as part of the same polypeptide and thus should be given the name "PTS system, glucose-specific IIABC component" while the B. subtilus enzyme also contains an enzyme III domain which appears to act independently of the enzyme II domains. This family is most closely related to the N-acetylglucosamine-specific PTS enzymes (TIGR01998). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	1.33144e-122

>NC_013595.1|WP_012888156.1|1479021_1479726_+|response-regulator-transcription-factor
MTEPDEATRPARSGDPIRVLIVDDHALIRRSLEMALSAETDIEVVGEASDGQEAVELADRLTPDVMLMDVRMPRRSGIEAARAIKASVPSTRIIMLTVSDEEEDLFEAIKAGATGYLLKNVQLDEVPEAVRGVHEGQSLINPAMAAKLITEFANMSRKEAERPPQLPVPRLTDREMEVLRLVAKGMNNREIAKQLFISENTVKNHVRNILDKLQLHSRMEAVVYAVRERMLEIT
>NC_013595.1|WP_012888155.1|1478269_1478926_+|ribosome-associated-translation-inhibitor-RaiA
MDIIVKGRHTGVSDRFRDHVTTKLARIERLDHKLISVDVEVTKESNPRIIGQRERVELTIHSRGPAVRAEATADDRFAALDIALGKLEGRLRRLADRRKIHHGNHCPPSLAELAATALAETLEAVPPRPREEPEVQSDFEADLSEDKTIVPIHMDGDGPLVVREKAHQADPMTIDQALLEMELVGHDFYLFRDKESGQPSVVYLRQGYNYGVLRLVEP
>NC_013595.1|WP_043651510.1|1477041_1477746_+|phosphoribosyltransferase
MPTALLDLVLPPRCAGCGVPGALVCPRCAAELHGRPACRMPVPSPPGLPECWSATDYTGAARRAIIAYKERGRTALAHPLAGALALTVAAAVGGRPVTLVPVPSARPALRRRGHDPVTRLAVLAAGYLRAAGWPVTVAKILAQRRRVADQAGLSSPQRAENLSLAFRVTAARKGALPGSWGGAGPIVLVDDIVTSGATLAEAARALREAGVAVPLAATIAATRRRGQSPSRDGG
>NC_013595.1|WP_012888153.1|1475175_1476939_+|GerMN-domain-containing-protein
MGTVGLIVALTCGVTACSVIPTGGKPISVGNPRKGNPLGDPYARVIAVPPSADWSPEEVVTGFRAAMASVDDPGRDVAREYLTEAFAREWNPQSGVTVYKQDGKQDQYEKAPPVQADAKQTRVTLKGTVTAMIDQDGRYWPKGGSLNEPFTLVKGAQGWRISAAPEGLMLSEADVDRAYLKVDLYFLDSAWRGLVADQVRVPIDPTSNFAKTAVERLLKGPSSLLKKAVNSAFRPGTRLIDVTTENNRVVVDLTKPVDSDRIAPMSAQLAGTLAELTKGGWGFEVRVEGKLYYSDSLLAIDAQQHADFDPWTAPRDVYPYYMAGGALQMLGKENVGQPVQGRAGEKDGTRTRPAISGQGQVAALSEDRTKVSVAPLAPGGEWQDWVTGDSLTPPSWDRYDTLWTVDRPDGNSSVVVRRDGRQQYRVWAPDLNTVHVTSLKVARDGVHVAVVVKNGLEEEVKIGTVVGHGSGTRITDLQSVVDGDGNQTIKDIAWKDGKTLYVLTGKSDLLEASVAAEPKTLASDSRIESITALDGSLLAGAQDDNGNRQVLYWNRTSAKWEPMVKDENGTVLFSEKDGPSSPAYPLG
>NC_013595.1|WP_012888152.1|1473422_1475162_+|HAMP-domain-containing-histidine-kinase
MPSSPKKRRRTPRQVVRGVRRRARRAAGGVRRVWRRSLQLRVVTSTMVISIAVVAVLGVFLMQQIIATTLQDRERAARSEAQADRNAVLGYLNRPSGDVSKPSVDSGDGLQRGGDSPLSQAVYALAGRAGAVPRYSVIARNDNQPGEFFVTPNIDPRSIPSGLREEVSKKEAGEDSTHYGDLYYEGRREPVRGMVIGTRLDTSGTMLDSGYEIYHLIPLDKEEETLNSVLRMLVAVGAALVLLLAAIASLVTRQVVTPVRLTRQAAERLAAGRLDERLKVRGEDDLARLATSFNDMAANLALKIHQLEELSHVQRQFVSDVSHELRTPLTTVRMAADLLYDAREDFDPMAARSAELMQNQLNRFESMLADLLEISRYDAGAAELDVDPVDVRDVVLRAVADSEALAERHSTRFDLRLPGEPCMAEMDSRRVERILRNLLFNAIEHGEGRDIVVSVGADRDAVAVAVRDHGVGLKPGEENMVFDRFWRADPSRARTIGGTGLGLAISREDAVLHGGWLQAWGAQGEGSQFRLSLPRVAGAPLRGSPLSLVPPEVEMRRTWRGHMTPVLSPAVADGGNDAD
>NC_013595.1|WP_012888151.1|1472717_1473395_+|response-regulator-transcription-factor
MKGRVLVVDDDAALAEMLGIVLRGEGFEPSFVSDGDKALDAFRDTRPDLVLLDLMLPGADGIDVCRRIRAESGVPIVMLTAKSDTIDVVLGLESGADDYIVKPFKPKELVARVRARLRRTDEPTPEILQIGDITIDVAGHSVKRDEETINLTPLEFDLLVALARKPRQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRAKIEKDPEHPEIVVTVRGVGYKAGPA
>NC_013595.1|WP_012888150.1|1471087_1472374_-|hypothetical-protein
MSDGHGSTPDTPPGWASNQPPPYGDAPGSPWTAPGSGPGAPPPQPPPQQPHGGQAPPYGQPPPHRPGPYGPPPHGFPPPPAMRPGIIPLRPLGIGDILDGAIKLIRSNPKTILGLSAIVAALGAIPVAIGQAVMIGDLGAGLDDPSVLEDPQDIGFLAQYGGTLISYAVQFVAVTLLTGVLTRILGRAVFGGKMSVGEAWQLTRNRVPTLFGLVAIGMLVMLIPMVVVIAVIAGLGAAGADFGALFLVGALAILGFVAYALFITTRLALAASVAVLERRGVIDSLRRSWNLVGGGFWRTLGILLLTQLITALVALVLSFPFTIMAFVVGMIGKGSTGSQIGTAILIAVGGTVSAMITYPFQAGVNGLLYADRRMRAEAFDLVLQTAAIEQQRQGWVHASADDLWDPSITPSGPGRYDQTGQGAPWRDS
>NC_013595.1|WP_148269480.1|1470431_1470965_-|DUF4129-domain-containing-protein
MRAVSQFLGDLLDQESVGVVGSVAARVVLAVIVIAAITAVVTIARRATRGGAVRQDGIFGDRRRTAAEHRDAAERLAAESRWAEAVRERLRAVARDLEDRAIVDSTPGRTAGELAAEAGRVLPAFAGELTTAARVFDDVTYGEVPGTAEAYEVLRDLDERLRTARPVPAAPAKAVPS
>NC_013595.1|WP_012888148.1|1469274_1470435_-|DUF4350-domain-containing-protein
MSLAAAPGTGSTSTSPTAATLWRGGRGILLVALIVVAGAVIGVLLSGSGGGRPLDPADTSPSGGRALAQLLRAHGVQVTRVTSVAEAEAAGSGDRTLLLSDTSFLGEEEARRLGAIPADLLVVGVQPHQELITPGVRPAEEARARSREPRCELRAATRAGSAYLGGSALTAPSGATGCYPADGRPTLVSYTDEGRTVTVTGDGQFMSNLRLAEDGNAALAMNLAGARPALVWLVAPETAARASGEQGFYDLIPGGVRWAVVQLAVAVLLLALWRGRRLGPVVAERLPVVVRAAETVEGRGRLYRARRARDRAAVALRTSFVDRVTPRLGLPSAAGPDAKVEAIAERTGQARLHVGAALYGPPPADEAGLVALAAYLDMLERQVKES
>NC_013595.1|WP_081453394.1|1468196_1469201_-|MoxR-family-ATPase
MPPENSGLAETPPVAGTAPGASAAREALAGLRAEVAKAVVGQDAVVTGLVIALLCRGHVLLEGVPGVAKTLLVRTLAAALSLDFKRVQFTPDLMPGDVTGSLIYDAKTSEFEFRQGPVFTNLLLADEINRTPPKTQAALLEAMEERQVSVDGKPRRLPEPFIVAATQNPVEYEGTYQLPEAQLDRFLLKLTVPLPPRDQEIAVLERHALGFDPRDLSHVKAVATIADLDAGRAAVSQVHTGPEVLGYIVDIARATRQSPSLQLGVSPRGATALLAGARAWAWLSGRSYVTPDDVKALARPSMRHRIQLRPEAELEGATADGLIDAILASVPVPR
>NC_013595.1|WP_012888157.1|1479933_1481115_-|YcaQ-family-DNA-glycosylase
MTVTLSADEARRIILRAQGLLGADARRGGAPATLRRLGAVQLDTISVLARSHELVAYARLGAVGRQRIERAYWDDPAQAFEYWCHAACVLPIDDWSLYAFRRRYLRARKYRWHEVPGNVDKVLEQVRESGPITTADIGGAKNGGLWWDWSDSKIAIEWLLDIGEVVCTRRVGWRRVYDLTERAVPAHLLAEDLSDAECITRLAGIAGRALGVATRADLVDFLRLRPAYAALLDASLLDGSAGLTPVQVSGWPDRSASAWADPAALEGEPRGRHRTTLLSPFDSLVWDRARTARVFGFSHRLEAYVPKEKRVHGYFTMPVLAGGRLIGRVDPAREGSTLVGRQVSLEPGVNQRKGAESLADALWEAASWVGCDDVRVDRVDPHLSAPLRHALAR
>NC_013595.1|WP_012888158.1|1481205_1481460_-|hypothetical-protein
MEDDAQRASHGGRASSWLAVTVIVLGFAIGGVGLCLGPMWPLFWMGAAVCVLGGILLLAFQVFRDVVLDAPRAPYRQAGAEPSE
>NC_013595.1|WP_012888159.1|1481712_1484520_+|preprotein-translocase-subunit-SecA
MPAFLDKILRAGEGKLLRKLKRIADQVNSIEDDFKSLTDAELRALTADYKQRHADGESLDDLLPEAFATVREASRRVLGKRLFDVQIMGGANLHMGNISEMRTGEGKTLTCALPAYLNAISGNGVHVITVNDYLAKRDSEETGRIHRFLGLDVGVILANMPPDERRKQYNADITYGTNNEFGFDYLRDNMAWSLEECVQRGHNYGLVDEVDSILIDEARTPLIISGPGEQSGKWYAEFAKIVPRLRRGTEGKDGEENTGDYAVDEKKRTVGIFESGVEKVEDWLGIDNLYKPEHTHLVGFLNNALKSKELYKKDKDYIVVDGEVLIVDEFTGRVLHGRRYNEGMHQAIEAKEGVKIKDENQTLATITLQNYFRLYKTLSGMTGTAATEANEFHQTYKLGVVPIPTNRPMIRKDQADVVYKNEDAKFMACVEDIKERYDRGQPVLVGTTSVAKSERLAKELKRKGIKHEVLNAKNHAREAAIIAEAGRKHAVTVATNMAGRGTDIMLGGNPDFRADVELRNRGLDPVETPDEYDKAWGEALEKAKEAVRAEHDEVTELGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLEDDLMRLFNSARVEMIMTRLNIPDDVPIESGIVSKAIASAQHQVEQQNFEIRKNVLKYDEVMNRQRKVIYAERRRVLEGADLHEQIRSFINDVVDEYIAGATAEGFAEEWDLDKLWKAIGQLYPTTLTIDGVLEEAGGREELTAEFLNEKVKADAMAAYDLREEELGPDTMRELERRVILSVLDRKWREHLYEMDYLQEGIGLRAMAQRDPLIEYQREGFDMFSQMLEGIKEESVGYLFNLEVEVQTNPIVEEHDHDHEHEDAAVAETRSIIARGLRGPQRPSELEYTAPGESGEVEHTRISSKAERDAYGNVERNAPCPCGSGKKYKRCHGDPRHVEA
>NC_013595.1|WP_012888160.1|1484597_1485107_-|hypothetical-protein
MSRTPRPVPLPRIAPSPSAEPPYDDERPAGDVPAAPPYVQGALALAYDPEPVEPPVRRPLIWGPPGAVPDERRLRALGQAVAEILSGRRPPSSVSSLLTERAHAELVRSGKIINCTRPPLVGTPHVSQPKDGVVEMCVLVHCGDRPRVLALRLERKGVQWLCTDFEATP
>NC_013595.1|WP_012888161.1|1485468_1486803_-|PTS-transporter-subunit-EIIC
MGTAAVERGPSIWSSVFAILQRIGRSLMMPIAVLPAAGLLLRFGQEDLLGRTDNAFLDQVAAVFAAAGGALFDNLPLLFAVGVAIGFARKADGSTALAAVVGYLVFDRVSKTLFFTASPTSEVYKKIALTVVGPDGRPLPLLNLGVQNPTGVLGGIVIGITAALLWQRYYRVKLPSWLAFFGGRRSVPIVTAVAALILGVIFGLLWRPVGDWLATVGDWLAAHGTAGAGVYGVANRLLIPIGLHHFLNTIVWFTLPECQAGVDGATRNASGDLNCYFAGQDGAGIFMTGFFPVMMFGLLGAAIAMWQAAPHGKRATVGGIMLSAGLTSFVTGITEPLEFAFIFVAPVLFVVHALLTGLSMALMAELGARLGFTFSGGAIDMLLNAGKSNTHRVGLIIVFGLIYFVVYYLLFTILIRKLNLATPGREQEDAEPPPSTATTGPPTP
>NC_013595.1|WP_012888162.1|1487021_1488362_-|PTS-transporter-subunit-EIIC
MSSTSADAGLPAPPSAGSAVMSVLQRLGRSLMLPIAVLPAAGLLLRLGKDDLVGRTDNPLLDDVAHVLGTAGGTLFDNLPILFAIGVAIGFARKADGSTALAALVGYLVFHAVSMTMFFNLFDDRLKVSISNRLFDPANPGVPEMALNLGAQNPTRVLGGIVMGLVSALLWQRYYRTKLPTWLAFFGGRRLVPILTAFAGLVLGVFFGFIWPIIGNWLRAFGTWLAENSTVGAGVYGMVNRALLPLGLHHIVNNVVWTQVPECVVDGKQLAGDLVCFNNGAMGYGGFEAGLYPILMFGLPAAAIAIWRAAPPHRRTAVGSIMISAALTAFLTGITEPIEFAFIFVAPVLFVVHIVLTGISLAIASALGAKLAFSFSSGLIDLVLYGTAPNAQGVPIIIVMGLVYAAVYYTVFSFLIRKLNIMTPGREPEPDVDSGEPATPPPARPA
>NC_013595.1|WP_012888163.1|1488398_1489139_-|GntR-family-transcriptional-regulator
MAQIDPDSPVPKYFQLREILLDLIENNELAIGMAIPSERELCQRFGLSRMTVRQAVDHLVSEGRLQRVAGKGTFVARPKIEMALRLTSFSDEMRARGMEPGSRDLDRRVVRASAHLARELGIRPGDEVHFIERLRTAADEPMCIERAHIPVSLAPDLDTHDLTGRSLYALLETRYGLVLDAGELTIDGGIADPGDADLLKLPRGGAVLLLQRRSFAGGVCAELGVSTYRADRYQLRTVLEIPARRA
>NC_013595.1|WP_012888164.1|1489299_1490334_+|SIS-domain-containing-protein
MTTKMRSEIAEQPAALRATLDALLPRVGEVEQLAGQTRQLLFIARGTSDNAAVYGRYLAEAHTGRLSTLAAPSIATTYKRKLDLDGVLAVALSQSGRTEEIVETLAWAKDCGARTVAITNGGEQSPLAQAADLALCTLAGEEKAVPATKTYTTQLAALAVLGLGLGADVDAADLQRVPDAVEKLIAEPGDLDAIVEGLADKPGVVVSGRGLAFSTALELALKLKEACYLHAMGLSYADLLHGPIAVVDEDTPAILVAAGEGPTLAGTVALAERVTGAGASAFTVGGGTALSSVATAALNGPDLPEWVAPLGLIVPGQLLTEALARRLGIDPDAPRGLNKVTQTD
>NC_013595.1|WP_012888165.1|1490386_1490623_+|PTS-glucose/sucrose-transporter-subunit-IIB
MAANADAIIAGLGGVDNIIEIEPCITRLRTEVRDASKVDQAALKAAGAHGVMAAGNIVQVVVGPEADTIASDIEDIIG
>NC_013595.1|WP_012888166.1|1490675_1491122_+|PTS-glucose-transporter-subunit-IIA
MTTVLAPVAGAAVGLRAVPDPVFSEGLVGPGAAIEPAREPGEAVSPITGKIVKLHPHAFVVVGDDGRGVLVHLGIDTVQLKGEGFRLLVSEGDQVSAGQPVVVWNPLEIEAGGRSPVCPVVALDAVEGSVTTLAQGAVRAGDELFLWA

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Crispr_ID: NC_013595_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_13

1720239-1720321

Orphan

Consensus_repeat	Method
CCGGTCCGTACGGCCGGGCGGGACGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_13

>merge|NC_013595|13|1720239-1720321|CRISPRCasFinder
CCGGTCCGTACGGCCGGGCGGGACGGGCATCGGCCCGCCACCCGCACGTTCCGCCACCCGGTCCGTGCGGCCGGGCGGGACGG

>NC_013595|13|13|1720239-1720321|CRISPRCasFinder
CCGGTCCGTACGGCCGGGCGGGACGG	GCATCGGCCCGCCACCCGCACGTTCCGCCAC
CCGGTCCGTGCGGCCGGGCGGGACGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012888339.1\|1706133_1708317_+\|malto-oligosyltrehalose-synthase	unknown	unknown	gnl\|CDD\|200475
NC_013595.1\|WP_012888347.1\|1717814_1718780_-\|DUF1722-domain-containing-protein	unknown	unknown	gnl\|CDD\|377367
NC_013595.1\|WP_012888353.1\|1724811_1725570_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NC_013595.1\|WP_012888357.1\|1728125_1728479_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236641
NC_013595.1\|WP_012888343.1\|1713000_1715145_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012888342.1\|1711378_1713004_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173412
NC_013595.1\|WP_012888350.1\|1720751_1722029_+\|deoxyribodipyrimidine-photo-lyase	unknown	unknown	gnl\|CDD\|223492
NC_013595.1\|WP_012888341.1\|1710030_1711389_-\|DUF4407-domain-containing-protein	unknown	unknown	gnl\|CDD\|379583
NC_013595.1\|WP_081453054.1\|1716078_1716858_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_013595.1\|WP_012888355.1\|1726675_1727632_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012888340.1\|1708320_1710030_+\|malto-oligosyltrehalose-trehalohydrolase	unknown	unknown	gnl\|CDD\|274114
NC_013595.1\|WP_012888352.1\|1723515_1724229_+\|adenylate-kinase	unknown	unknown	gnl\|CDD\|183758
NC_013595.1\|WP_012888358.1\|1728516_1729194_-\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NC_013595.1\|WP_012888351.1\|1722398_1723079_+\|DUF899-family-protein	unknown	unknown	gnl\|CDD\|377584
NC_013595.1\|WP_012888356.1\|1727721_1728123_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319943
NC_013595.1\|WP_043651558.1\|1724515_1724893_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012888348.1\|1718776_1719301_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|237125
NC_013595.1\|WP_012888354.1\|1725647_1726535_-\|peptidase	unknown	unknown	gnl\|CDD\|370782
NC_013595.1\|WP_012888346.1\|1717040_1717547_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012888344.1\|1715216_1715960_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012888339.1\|1706133_1708317_+\|malto-oligosyltrehalose-synthase	gnl\|CDD\|200475	cd11336, AmyAc_MTSase, Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase). Maltooligosyl trehalose synthase (MTSase) domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-glucosidic linkage at the reducing end of the maltooligosaccharide through an intramolecular transglucosylation reaction, while MTHase hydrolyzes the penultimate alpha-1,4 linkage of the reducing end, resulting in the release of trehalose. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NC_013595.1\|WP_012888347.1\|1717814_1718780_-\|DUF1722-domain-containing-protein	gnl\|CDD\|377367	pfam04463, DUF523, Protein of unknown function (DUF523). Family of uncharacterized bacterial proteins.	2.33287e-47
NC_013595.1\|WP_012888357.1\|1728125_1728479_-\|hypothetical-protein	gnl\|CDD\|236641	PRK10019, PRK10019, nickel/cobalt efflux transporter RcnA.	0.00551619
NC_013595.1\|WP_012888342.1\|1711378_1713004_-\|hypothetical-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	4.6372e-08
NC_013595.1\|WP_012888350.1\|1720751_1722029_+\|deoxyribodipyrimidine-photo-lyase	gnl\|CDD\|223492	COG0415, PhrB, Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair].	3.85084e-140
NC_013595.1\|WP_012888341.1\|1710030_1711389_-\|DUF4407-domain-containing-protein	gnl\|CDD\|379583	pfam14362, DUF4407, Domain of unknown function (DUF4407). This family of proteins is found in bacteria. Proteins in this family are typically between 366 and 597 amino acids in length. There is a single completely conserved residue R that may be functionally important.	7.88371e-77
NC_013595.1\|WP_081453054.1\|1716078_1716858_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.70659e-26
NC_013595.1\|WP_012888340.1\|1708320_1710030_+\|malto-oligosyltrehalose-trehalohydrolase	gnl\|CDD\|274114	TIGR02402, Malto-oligosyltrehalose_trehalohydrolase, malto-oligosyltrehalose trehalohydrolase. Members of this family are the trehalose biosynthetic enzyme malto-oligosyltrehalose trehalohydrolase, formally known as 4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase (EC 3.2.1.141). It is the TreZ protein of the TreYZ pathway for trehalose biosynthesis, and alternative to the OtsAB system. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_013595.1\|WP_012888352.1\|1723515_1724229_+\|adenylate-kinase	gnl\|CDD\|183758	PRK12803, PRK12803, flagellin; Provisional.	3.9392e-63
NC_013595.1\|WP_012888358.1\|1728516_1729194_-\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	6.59653e-127
NC_013595.1\|WP_012888351.1\|1722398_1723079_+\|DUF899-family-protein	gnl\|CDD\|377584	pfam05988, DUF899, Bacterial protein of unknown function (DUF899). This family consists of several uncharacterized bacterial proteins of unknown function.	1.54171e-49
NC_013595.1\|WP_012888356.1\|1727721_1728123_+\|VOC-family-protein	gnl\|CDD\|319943	cd08355, TioX_like, Micromonospora sp. TioX and similar proteins. Micromonospora sp. TioX is encoded by a gene of the thiocoraline biosynthetic gene cluster. Thiocoraline is a thiodepsipeptide with potent antitumor activity. TioX may be involved in thiocoraline resistance or secretion. TioX belongs to vicinal oxygen chelate (VOC) superfamily that is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.80364e-36
NC_013595.1\|WP_012888353.1\|1724811_1725570_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	2.99414e-35
NC_013595.1\|WP_012888348.1\|1718776_1719301_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|237125	PRK12519, PRK12519, RNA polymerase sigma factor; Provisional.	2.07962e-33
NC_013595.1\|WP_012888354.1\|1725647_1726535_-\|peptidase	gnl\|CDD\|370782	pfam10026, DUF2268, Predicted Zn-dependent protease (DUF2268). This domain, found in various hypothetical bacterial proteins, as well as predicted zinc dependent proteases, has no known function.	1.07765e-29

>NC_013595.1|WP_012888348.1|1718776_1719301_-|sigma-70-family-RNA-polymerase-sigma-factor
MEDNLNIRLAGGDDAALADCFHAHGSLVRSYLRRFVPPQEIEDLQQVVFAEVWRSRHRFDPARSLPAWLIGIAHNRAVDHLRARTPQTVPLDVVADPAGADGRTHGDGLAERDQVQRALAELPAPQRQAIELAYYGELTQREIAEKLSVPLGTVKARTARGLRRLSDILTPVAA
>NC_013595.1|WP_012888347.1|1717814_1718780_-|DUF1722-domain-containing-protein
MSGQAGGHVRPRVAVSSCLMGEPVRFNGGHSRDRFLSGELDPYVDWVRICPEMEIGLGTPRETLRLERSPEGPRLVTRKTGVDLTGEMTSLAAGRARTLDVDGYVFKSRSPSCGIHGIPVYAGDMAVDRRGRGVFAGRILDAHPLLPVEDEGRLNDALLRETFVERIFAHARLRALMESDWHARDLVAFHSRHKMQMLAHDPALYREAGRVVARAGLRAREELGADYVHVFGGAFARKAGIGRHVNVLQHCMGMVSESLDRTQRADLAEVIASYQAGQVALSVPVTLLRHHARGESAEYLRDQTYFSPYPEELRLRNHVPV
>NC_013595.1|WP_012888346.1|1717040_1717547_-|hypothetical-protein
MAKHDPVENAWKIHQSLSDWTGKVDSKASFALTMESIVLATILGLSGAGRRFSNLHEWWTAVPFWLGVAALALSVLMSISVVAPRIRTGYVKAEAERNFIYFGHLQHWQPGDLVNELSRTDPLPNLCRQIVNMSRIAWVKHRRVQQSFYTATAGAGLVAAAGILSQYQ
>NC_013595.1|WP_081453054.1|1716078_1716858_-|Crp/Fnr-family-transcriptional-regulator
MTRQELPGGGRVHQSASTGHAPGHWAPNTLMTDLDAAAGKALLALGTVRRCAPDTVLIRQGERGDRRVYLLEAAGPDRPACAKVTLASESGTEALLGIRLSGELVGELAALRDEPRTATVTVCSYSLVHVLSEERFAAFMDRHPSAGRAIARMVAQRLDWANRRRLDLAEGTVAERLARVLVELVDRHGSRDRDGHLLGVPMSQAELGRLIAAGPDAIGKAVARLKAQGLIRGGYRGVTVLNLDALRKYEDMRQKHPEG
>NC_013595.1|WP_012888344.1|1715216_1715960_-|hypothetical-protein
MSKNHRRRLLIKTDIVSYGTRDDRDQRAAQRNFIHLLDEAAENAGLNRKKWFTQSSGDGEFAILPGREPEQRVVDDFVRQLDSALGHHNAGVLPSTRIRLRVAIHVGVISPADNGIAGAAAVAVGRMVDCAPLREAIAAAEPADLALIVSDEIYRGTIAGRLTTWRDDDFHEVTVQVKELTARAWIHVPRGGLSPHGSPERGSRGHGGPPGQAAARPHEEAQASPVVVNTFYGTVHTQGGTIGISNG
>NC_013595.1|WP_012888343.1|1713000_1715145_-|hypothetical-protein
MSTPDPSAPEDEGPDDRAADSGAPASDAPPDGGAPGAGPEDGEPDGGAGGGAARPAPEGRIDQTVFQTFLGSVHTHGGTVGISGDGARTQSRRASGKVSPADIDSAVHRYAPPAPHAHALSELRGNHVVALYGAAGLGKRTSAINLLHTVAGGPLVTLSPADPLGWLAERDYTEGAGYLACGLVSSGEQTELADFTLGEIARRVQEAGAYLVLTVVTPLTDTRSGAIPHIGWSQPAHRDVLLAHGVDPARVTAATQEITSAHDLGDVVRFAVQLAGGTSLEEARGGLDLTGRVVAWFEDGRRTDDEILEVTALLFMVGMPERRFEAHLARLRERTAPVAEEPEAPAVRAGVLAARRPRRDGDSLIKIEYLVTEMDVDIPGPPRRCLVFREYGHRRHVAAELCAQFDDRFWAPVFAWLLETVQASGPETRLQIAAGLALLCGHDSFDAVREVFLQPWSAGEYGPRSWDTAIYVLWCMCVEDTTAPLALRTAIRWSRSGIALRRLAAAEAFCGELGVRYPAEALSQLWHLMENGPPYEGREAVARLYATLVSGAARDARVVLDDLEMRLRQHPRPGSPQLLRTLNVALAVLSIRDGTTGHPAAARHLLMPGTLLGPFAKIWSTAIVNRPARAAAFEALYDVLHAMSVLSPSPEERLRPLAEALAASLPDHEHGPFRSEFERYVNRRRDPQSSGRLLLSILLSIFTPNSRPHPVESR
>NC_013595.1|WP_012888342.1|1711378_1713004_-|hypothetical-protein
MTQPIVTEPSPSPPEQAGYPITALDTLAPGAGRGRFWRRGPVQRKAGAVPYPLPHEVVVLRVGRRLVRADDGTPKDRDQDLAAATSYCVVDMTRERPVILEMQVPSEGGLQDFTLRATFACTVRDPLRIAEGGRRDIREALLTYVKSCDGIQHLGMEYGIEAVREAHRRFRSALDTYARTRPPVFTGMMVELTAVEVLTPAEIMEEQRRDESLRRQREKERALEEENIAAQSHIERLQQELETQRIELQERLHRQKTAFDQERQIVEREFGWKMQYDEAEEKRRRDYRQRTFDIDEGLRLHEAVGTDPDKIEAMTRVQGGLSAGDHLARSDERERLRREKEEKDLRWRRETEREQSQWGRDWEVTRAGWERDDNRDGLQWDRRLQAEARQRAQEIEDRKITAEAGAEAEARRRAQELEDRKALAEAEARRRAQELEDRKILAEAEARRRAEEIEDREAAAQLELVRILVERGHTDQGSMVEHVQRLADELTSRRRPLQHERRTEITRDDARPALQDPPAPQERRYAENDRPARLKEEDIGD
>NC_013595.1|WP_012888341.1|1710030_1711389_-|DUF4407-domain-containing-protein
MAIETVGQTTGPADETPPRDPRDGYRPRSAWSPGRLLRSVVGIDEVLLTRVPEERPRYTRQGALVVATAVMAAMSMGYALRSVFDAPWPVVVLIALIWGVLIGILDSWLVISTNGVIGRGRRRMLLPRLLIAVVVGVIIAEPLTIRIFESAILQRIEQDYQEADKTLRSDYASCYPKAGEPAADPVKCREFRLNLPKPNDTDARKALEATRAKLSREFNAKQRILARKQRAADLECNGTSGAGRTGRAGEGVNCQRLRADVNDYRNTSNIGQLSTGMAGLDAQIIELSGTERVSGMKYEAQVAEAIDSEVRRQDEARPDSPGLLERMETLAALSAEKDSILLAHTFLTLLFLLIDCSPVLTKLLSRPTSYDRRLAEQLSDREEAHTVDLDRGKRVRRDADEVHAHQAELKVREHMTAASRRAGILDARREAAIRAELGAIDAERGSGPDGRD
>NC_013595.1|WP_012888340.1|1708320_1710030_+|malto-oligosyltrehalose-trehalohydrolase
MFEVWAPQATAVDVEIGEIRHPMAAGTGGWWSAEVPGAGHGTDYRFRVDGGEPLPDPRTRWQPEGIFGPSRVYEHDRYVWGDGLWRGRDLPGSVIYELHVGTFTPAGTFDAAIGKLEHLAGLGVDFVEVMPVPPVPGERNWGYDGVDLWAVTENYDGPDGLKRFVDACHRQGIGVILDVVYNHLGPSGNFLAPFGPYFHSSASSFWGQAVNLDGPGSDEVRRYFIGNALQWLRDYHIDGLRLDAVHALHDRRAVHLLEEMAAEVEALSAAVGRPLTLIAESDLNDPRLVTPREAGGYGLAAAWNDDVHHALHVAVTGERHGYYDDFAGALPKVLASAYYHDGTYSAFRGRSHGRPARHVPGYRFVCAAQNHDQIGNRAEGDRMAPEALRLAAGLLLTSPFTPMLFMGEEWGARTPFLFFTDHVEPQLREGEADRRRREFVGFGYDDWAEKAPDPGEELTFLRSKLDWSELDDDAHRVHLDWYRALIALRRAHPDLSDPRLDRVRAEHDGSWLVVHRGAFRVAVNFGATPVSLDLTAPAQVVLASDPGVHLDSGLTLPARSLAVLRLAGT
>NC_013595.1|WP_012888339.1|1706133_1708317_+|malto-oligosyltrehalose-synthase
MSERFVDPISTYRIQLTPDFGFAEVAALAPYLKDLGISHVYLSPILQAVPESRHGYDVTDHSRIRAEFGGVEGLRALSATLAEHGLGIVVDIVPNHMTVPVPESGNAPLWSVLKDGQASPYAPWFDIEWTGGKVSMPVLGDDTEPVVDGDVLRYHDHEFPFPDTCYRLVDWREGPGYRRFFDVSSLIGLRVEDPEVFDATHEVILGLIEEGVVHGLRVDHPDGLAEPRGYLSRLREASGVWTVAEKILVGSEQLPADWDCDGTTGYEVLNRITRLFVDPAGGKPLLELFVTRTGMPSDYATVVRQSKREVLDLFFSAEVDRLNAVVGSDRETLVELLAAMPVYRAYAVPGEPVPEISASIVEAAGRVAAARLPEGAPVAEVVDRVLRGPAEAVTRFQQTCGPVMAKGVEDTALYRWYPLACLNEVGGEPDHFEGTPGEFHTFAREMSPTAMTTLSTHDTKRSEDVRARLAVLSELPGEWAAAVGEWSSKVSFDPALDYLAWQNLMAAWPIGPDRFFDYLFKAAREAKTSISWAAPDPAYEAGIRDFVSRAIDECGASVAEFAAGIEPYARSNSLGQKLVQLMLPGVPDLYWGNEITDFSLVDPDNRRPVDFPLRRGMLAGEGGSPWDEAKLLVTVQALNLRRRLDPAAPYVPLEAGEHVIAFARGERAVTVATRLPAGLARRGGWGSETITLPHGAWRDLLTGAEHTGRIPLAHLLSTYPVALLERE
>NC_013595.1|WP_012888350.1|1720751_1722029_+|deoxyribodipyrimidine-photo-lyase
MDTVIVLFNRDLRVHDHPALAAACADAWRVVPLFVIDPGVPGGHRAGFLAESLDDLRGSLRERGGDLVVRQGDPVAETLRLARELPAQAVYVSADVSALAQRRERRLAEECERHRMEFRAFPGVTIVPPDALRPSGGGDHYRVFTPYWRVWSGQRRREVLGAPAKVRIPEGLEAGPLPVAGHEPHGLFRGGETVARERMRQWLKYCVEDYADGHDDLAGNRTSKLSPYLRFGCLSPLELESLSENGDDFVRQLCWRDFFHQVTRAFPRINRDDYRPQGQEWRDDEDAAQAWKEGRTGVPIVDAGMRQLLAEGWMHNRARMVTSSFLVRRLRVDWRVGAEHFFDLLLDGDVSNNYGNWQWVAGTGNDTRPNRIVNPVRQARRFDPEGEYIRRYLPELDAVPVKMIYEPWRMSTGIRGYPAPLVSMD
>NC_013595.1|WP_012888351.1|1722398_1723079_+|DUF899-family-protein
MRQTELIGESAEYLAARKELRLAEIDLMRHREKVAAQRRALPQGPPVDDYVFIEGPADLDAGDAPIREVSLSGLFTAPDRPLIVYHLMYGKLQTDPCPMCTLWIDGFNGIAHHITQNADFAIAAAADPPALRQHARNRGWHRLRLLSCGDSTFKYDLGSEDKDGEQDSTISVFTRDGDGAVRHFYSTHPRMADDIDQRGIDLLAPVWHLLDLTPNGRGDWFPSLDY
>NC_013595.1|WP_012888352.1|1723515_1724229_+|adenylate-kinase
MSDGNTTPGAGPADVGQYEARPNEVIRAARNASQALEFIRTTEGHLNELTNVLQRMRVLSIQSANGTYSEEDRSVVQIEVDQLTDEISRVADQMNFNKMRMLTDASAAANVRAADELGMTPAKINTPPSLANAQGAWTLRVHAGANTNEALAVNIFAANVANLFTAEGAPLDSKVALTAKGPAPVGGKPAKPVNVMTASDANARIAKIDIAIKAVTDQKSDLNTLRDHLEGQARDAH
>NC_013595.1|WP_043651558.1|1724515_1724893_+|hypothetical-protein
MTSQDRAAAAWAALDERQQAYTRVIYDADQAAEQRAKARGWKDIARLVSLREKTPGSAGDYVPPPGGHGGDTICEYPKQPSGRELSPTSGEDRSSCGTSYIRVRAYACSASRTNAAPAASSYMAA
>NC_013595.1|WP_012888353.1|1724811_1725570_-|MerR-family-transcriptional-regulator
MEWSIQELAARAGITSRTLRHYDRVGLLAPSRIGANGYRYYDPTAVARLQRILLMRRLGMGLPAIAEVLADEVDTCDGLRAHIAELEEERDRVERQIRSVRHTLEALQAGAEPRMDVMLAGFNDHYKDEVISRWGERAFQVSNDWWHGKSLDQQRAWKQASEDLVAAWVAAARAGISPTSARAQTLAARHVRWLSEIPGTPTADGDRERSIAMVKGVGDMFVDDPRYAAMYEDAAGAAFVRDALQAYARTRM
>NC_013595.1|WP_012888354.1|1725647_1726535_-|peptidase
MSITVLDTYSAMKQILRAPVADRVDLLRSMLEANKGMYRYHPGELDLVAVHLQSSGFPIDRDEERCLDALETLAAAGAWERMQRALDDALAVLLEATPGLEAPDITVLFVLGDPGDKHFMGPCKGLTGFGGISGNIAITFWPFPENVERLEATAVHELHHNLRWSPGGVVWDPMTVTVGEHIVGEGLADAFARQLYGDELGPARIGVPHLHDDEVFAKVLTGLDVTGMQNFTAWVHGDPGAEHLGVTPVGLPMGAGYAAGNRLVDTYLAATGQTAAQALHADSAKIIAATLHSES
>NC_013595.1|WP_012888355.1|1726675_1727632_+|hypothetical-protein
MRRKYVISFDSVDDDLRAARDRVRRLEQLTRQRQAVAVQLDEVGRLIGDLEAGLAKEERDVSRLEGGGFAAFLAGLAGSKEEKLARERAEAQALRQRLDGQRTRLGWLQADRAAVEDGLAEVAAAREEFAALLERKERSLVESADPRGRELAEIGRRLADTHADLREHEEAHLAGVAAGQAVGQVLRCLGGARGASTWDMLGGGGFADMVEHGHMRDADEAAWHAQRALDAFSRELADVGVHVNPQLPEVDTRWFADVFFDNIITDAIKHQRIARTGEAVTEVARWVSGTVDDLAARRGELARHRDSLAARREDVLTG
>NC_013595.1|WP_012888356.1|1727721_1728123_+|VOC-family-protein
MSTPLVVPFLRYQDAPAAIEWLGKVFGFRPVLTLPGGKGGVGYARLALGDAVVMLASVRDSEPYLRSALDLPAVSQGVFVVVEDLEAHYEQASAMGAEIVLDIEATPEGTRVYLAFDLEGQLWAFGDGFVVND
>NC_013595.1|WP_012888357.1|1728125_1728479_-|hypothetical-protein
MSDESGTERYLRLTVELTVEVQDIGALQAAALKEINHPDADLDDDERREQAEMVSADDSGATALQWLIEPDHVLGLIEHVEQIEPREAVLGVEPSEGPSDEEDEHDHDHEHGHDHKH
>NC_013595.1|WP_012888358.1|1728516_1729194_-|uracil-DNA-glycosylase
MSARPLNEVVEAGWATALEPVAEKIAAMGDFLRKEVAEGRQYLPSGPNVLRAFQQPFDQVKVLIVGQDPYPTPGHPIGLSFSVAADVRPIPGSLRNIYKELTEDLGLPMPSNGDLTPWAEHGVLLLNRVLTVVPGKPASHRGKGWEEVTEQAIKALAARDKPLVAILWGRDARNLRPMLGDVPAIESAHPSPLSARSGFFGSRPFSRANELLEQQGTTPVEWKLP

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Crispr_ID: NC_013595_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_14

1747444-1747535

Orphan

Consensus_repeat	Method
GAGCCGCCGAGTGAGCGAGGCGGACGAGAAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_14

>merge|NC_013595|14|1747444-1747535|CRISPRCasFinder
GAGCCGCCGAGTGAGCGAGGCGGACGAGAAGGTGAACGCGACCATCGGGCACCGAGCGGCGAGCCGCCGAGTGAGCGAAGCGGACGAGAAGG

>NC_013595|14|14|1747444-1747535|CRISPRCasFinder
GAGCCGCCGAGTGAGCGAGGCGGACGAGAAGG	TGAACGCGACCATCGGGCACCGAGCGGC
GAGCCGCCGAGTGAGCGAAGCGGACGAGAAGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012888375.1\|1749008_1749818_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|200589
NC_013595.1\|WP_012888373.1\|1746044_1747427_+\|diaminopimelate-decarboxylase	unknown	unknown	gnl\|CDD\|143501
NC_013595.1\|WP_012888383.1\|1759774_1761100_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NC_013595.1\|WP_043651560.1\|1741109_1741361_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_148269490.1\|1756039_1757104_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133016
NC_013595.1\|WP_012888364.1\|1735100_1735853_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NC_013595.1\|WP_012888381.1\|1757100_1758822_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|132997
NC_013595.1\|WP_012888368.1\|1740682_1741120_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012888377.1\|1751666_1753589_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|366154
NC_013595.1\|WP_179949557.1\|1753588_1755151_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|366154
NC_013595.1\|WP_012888374.1\|1747548_1748841_+\|homoserine-dehydrogenase	unknown	unknown	gnl\|CDD\|235783
NC_013595.1\|WP_012888379.1\|1755285_1755768_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274765
NC_013595.1\|WP_012888366.1\|1738302_1739991_-\|maltose-alpha-D-glucosyltransferase	unknown	unknown	gnl\|CDD\|274140
NC_013595.1\|WP_148269489.1\|1743281_1745186_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NC_013595.1\|WP_012888363.1\|1734597_1735104_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_013595.1\|WP_012888365.1\|1735928_1738208_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226957
NC_013595.1\|WP_012888372.1\|1745196_1745853_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214846
NC_013595.1\|WP_081453057.1\|1758882_1759776_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|252734
NC_013595.1\|WP_012888376.1\|1749966_1751670_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|366154
NC_013595.1\|WP_012888370.1\|1741503_1743162_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238949

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012888375.1\|1749008_1749818_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|200589	cd10967, CE4_GLA_like_6s, Putative catalytic NodB homology domain of gellan lyase and similar proteins. This family is represented by the extracellular polysaccharide-degrading enzyme, gellan lyase (gellanase, EC 4.2.2.-), from Bacillus sp. The enzyme acts on gellan exolytically and releases a tetrasaccharide of glucuronyl-glucosyl-rhamnosyl-glucose with unsaturated glucuronic acid at the nonreducing terminus. The family also includes many uncharacterized prokaryotic polysaccharide deacetylases, which show high sequence similarity to Bacillus sp. gellan lyase. Although their biological functions remain unknown, all members of the family contain a conserved domain with a 6-stranded beta/alpha barrel, which is similar to the catalytic NodB homology domain of rhizobial NodB-like proteins, belonging to the larger carbohydrate esterase 4 (CE4) superfamily.	3.2133e-54
NC_013595.1\|WP_012888373.1\|1746044_1747427_+\|diaminopimelate-decarboxylase	gnl\|CDD\|143501	cd06828, PLPDE_III_DapDC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase. Diaminopimelate decarboxylase (DapDC, EC 4.1.1.20) participates in the last step of lysine biosynthesis. It converts meso-2,6-diaminoheptanedioate to L-lysine. It is a fold type III PLP-dependent enzyme that contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. DapDC exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity.	5.72378e-156
NC_013595.1\|WP_148269490.1\|1756039_1757104_+\|glycosyltransferase	gnl\|CDD\|133016	cd02525, Succinoglycan_BP_ExoA, ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.	9.56379e-06
NC_013595.1\|WP_012888363.1\|1734597_1735104_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	5.61625e-20
NC_013595.1\|WP_012888381.1\|1757100_1758822_+\|glycosyltransferase	gnl\|CDD\|132997	cd00761, Glyco_tranf_GTA_type, Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold. Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.	3.47309e-17
NC_013595.1\|WP_012888366.1\|1738302_1739991_-\|maltose-alpha-D-glucosyltransferase	gnl\|CDD\|274140	TIGR02456, Trehalose_synthase, trehalose synthase. Trehalose synthase interconverts maltose and alpha, alpha-trehalose by transglucosylation. This is one of at least three mechanisms for biosynthesis of trehalose, an important and widespread compatible solute. However, it is not driven by phosphate activation of sugars and its physiological role may tend toward trehalose degradation. This view is accentuated by numerous examples of fusion to a probable maltokinase domain. The sequence region described by this model is found both as the whole of a trehalose synthase and as the N-terminal region of a larger fusion protein that includes trehalose synthase activity. Several of these fused trehalose synthases have a domain homologous to proteins with maltokinase activity from Actinoplanes missouriensis and Streptomyces coelicolor (). [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_013595.1\|WP_012888377.1\|1751666_1753589_-\|glycosyltransferase	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	6.20889e-08
NC_013595.1\|WP_179949557.1\|1753588_1755151_-\|glycosyltransferase	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	1.49031e-15
NC_013595.1\|WP_012888374.1\|1747548_1748841_+\|homoserine-dehydrogenase	gnl\|CDD\|235783	PRK06349, PRK06349, homoserine dehydrogenase; Provisional.	0
NC_013595.1\|WP_012888379.1\|1755285_1755768_-\|hypothetical-protein	gnl\|CDD\|274765	TIGR03752, conj_TIGR03752, integrating conjugative element protein, PFL_4705 family. Members of this protein family are found occasionally on plasmids such as the Pseudomonas putida toluene catabolic TOL plasmid pWWO_p085. Usually, however, they are found on the bacterial main chromosome in regions flanked by markers of conjugative transfer and/or transposition. [Mobile and extrachromosomal element functions, Plasmid functions].	0.00998028
NC_013595.1\|WP_012888383.1\|1759774_1761100_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.1726e-26
NC_013595.1\|WP_148269489.1\|1743281_1745186_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	4.24245e-05
NC_013595.1\|WP_012888364.1\|1735100_1735853_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	4.00623e-109
NC_013595.1\|WP_012888365.1\|1735928_1738208_+\|ABC-transporter-permease	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	3.59993e-15
NC_013595.1\|WP_012888372.1\|1745196_1745853_+\|hypothetical-protein	gnl\|CDD\|214846	smart00836, DALR_1, DALR anticodon binding domain. This all alpha helical domain is the anticodon binding domain of Arginyl tRNA synthetase. This domain is known as the DALR domain after characteristic conserved amino acids.	2.49076e-11
NC_013595.1\|WP_081453057.1\|1758882_1759776_-\|SAM-dependent-methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	1.83036e-107
NC_013595.1\|WP_012888376.1\|1749966_1751670_-\|glycosyltransferase	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	1.86307e-13
NC_013595.1\|WP_012888370.1\|1741503_1743162_-\|hypothetical-protein	gnl\|CDD\|238949	cd01991, Asn_Synthase_B_C, The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the assembly of asparagine from aspartate, Mg(2+)ATP, and glutamine. The three-dimensional architecture of the N-terminal domain of asparagine synthetase B is similar to that observed for glutamine phosphoribosylpyrophosphate amidotransferase while the molecular motif of the C-domain is reminiscent to that observed for GMP synthetase .	5.86941e-08

>NC_013595.1|WP_012888373.1|1746044_1747427_+|diaminopimelate-decarboxylase
MSRFAHPAGDRHAEVLPEERPPHAPADLNTLDPTIWPRTSNRVDGAVTIGGADVRDLVREHGSPLYVVDEEDFRSRCRDYREAFTGGEVHYAGKAFLCREVARWIMQEDLGLDVCSAGELAVALSVGFPPERITLHGNNKSLAELEKAVEAGVGHIVADSFEEIARLGFLADKHGRRPQVMIRVTVGVEAHTHEFIATAHDDQKFGFSLSSGAAAEAARRILALPQLELVGLHSHIGSQITDTAGFEVAARRLATLLVQIKEEHGVVLPELDLGGGYGIPYVEGDTALDVKEIADGLRGIVANVARSAGLPVPKLTVEPGRAIAGLAGVTLYEVGTIKDVEGLRTYVSIDGGMSDNIRTALYGAEYTARLASRESSSGPMLSRLVGKHCESGDMVVRDLWLPEDLATGDLVAVAGTGAYCRSLANNYNYLPKPAVVAVKDGVSRVIVRRETEDDLLRGQL
>NC_013595.1|WP_012888372.1|1745196_1745853_+|hypothetical-protein
MTPGQLGEVLGLPPIPSGTWAEEALYVSPAALRRKEAPGEMAARLRALPGIAGVRVRGDGFLEIAVAVPGELVAEIGPVPPAAGGVPPWADLPRTWDNPGFIVRFAHVRAVAVQRWAADLGVGGDFRPELLAGRWDRAVLRSLAEVHGRRVSRDPGWAAYTEQLARAYHDAFERAPALPAGDEEPSALHAARVRLARAVRDVLAEGLAALGETAPDRL
>NC_013595.1|WP_148269489.1|1743281_1745186_+|glycosyltransferase-family-2-protein
MAEAARAAELARLLDAAQAKITEAERATAELRGVQERLSEAEKRLEAAHTAEERLRRDLAEQRYQAEVAKWKLSSVQVARWSRIGDALKTGKSNPVRLARGLRGAARPAKRPAAPKRQPVSPQGSDRSAAATASFQATTSTRTVGGTSVKLKPFRVPTGPNTRPHLTVAVVADPHAEALLRYEWRQSAGFTPRDFARVLAAEVPHLLVVESVTEGPWAEELREPGEGLNALLSWCAERGIRTVFWHTGGDVGRSVAAARLFEHIVTALPRSVAEWGATLASREPEPGRRAPSLGLLPFAVQPRVHNPLPLAGDRFDRVLTLDELLPGHLSYPDVLTSYRWPRAVDCPPGTEAWRLAELAACGTPIASSGPSGPAPESSAAAADADARRAHVALRRAYGSGTMSQKVDDLLDAVGLPSARATLNISVIMIDRGDLGHTLAQVAPQKGVVQLVLLSDAPDAAERARAAMPPRVDVVVRPADPGLTTGGQLDRALDLCQGDLVAVMDARDAYGEHYLTDLARAFLFTTADIVGKAAFYAHLRDVAATVLRQPAAEYSYLPEVAGATLLARRTVLRGLGFADVSEGWDEVLMRQCRTDGVKVFSADRFGYVCLRDHDSRLLGSARLVDYGPPAPHALI
>NC_013595.1|WP_012888370.1|1741503_1743162_-|hypothetical-protein
MQWPTFNVRPYVCGGIGHLDESALETLREAGPRVKPALRTPEAALYSSSPLPPYQRDTRSWAFAWGERRPAGPAPWISVAEEFETPGLIDDGDRIALHAGGLGLVDVYYLTRDGAVYFSSLLEPLLALARTPYEINWDAWASIIQLTFPLRDDTPYVQVKRLAGASALVFDRASGRVSTERRLPRWLREEPFEAGRTAGEILEILHEVYKEFDGRPLLVPVSGGYDSRLLCSVAVTRGADVESWTTSPDDGTDTDIAFARAITRELGVRHRVITQDASAYPDDALAAARRLEFLTPHHAWYTPFAREVHRAGRTLVDGLAGGPLLKNFMVSGAALEASSQAERKAALLGSLALGTPSVPFLSEEAAAWITSSVETAFGQSTSMLNGHRAELPLSVLHTRTARGIARSPVNLVGPEVSFAAPFTHPDFFDAALSVGVARKDKGRFYREVLYAANPRVAALPSTNVVKQPLQRVPLRSAAAPAREYGHRMLTRVAGTVPSLLSEPLHAVVAEGPDALARFNGWNDRFWVRSLVLFGAWLGDYEDRLPTLTPPWT
>NC_013595.1|WP_043651560.1|1741109_1741361_-|hypothetical-protein
MSTKPVTATLEADLLAYVQEQVNLGRARSVSAYLNAALERQIAIDRRADAAWKAAVEKAQQNPEEVEKARRRAQRLIEILNGG
>NC_013595.1|WP_012888368.1|1740682_1741120_-|hypothetical-protein
MEGDVKQALVLDVSVLTECARGDVGIINLIQQFDADRKPLIIPAMAVTGATVELGGDQDQLAVVSGLCRLDSANLTAVSDFKDGVEVGQVLIEVESCTTPWDAHAVTEALLHRCPILTTDYARWKGIVQDLSGGLTIVEIADLGE
>NC_013595.1|WP_012888366.1|1738302_1739991_-|maltose-alpha-D-glucosyltransferase
MNPSPYLEPVSEDFVSADPQWYKRSVFYEVLVRGFKDSNGDGTGDLRGLIEKLDYVKWLGVDCLWLLPLYESPLRDGGYDISDYMKILPDFGDLGDFIQLIESAHERGLRIITDLVMNHTSDKHPWFQASRHDPEGPYGDFYVWSDEPTGYPDAPIIFIGAEESNWTYDPVRKQYYWHRFFHHQPDLNYDNPAVQEAMLEVLRFWLDLGIDGFRLDAVPYLFEREGTDCSGLPETHAYLKKVRAEVDRLYPDRVLLAEANGWPEDVVEYFGDPSVGGDECHMAFHFPLMPRIFMAVRRGSREPISEIMSRTPKLPDSAQWGIFLRNHDELTLETVTEEERDYMHAEYAKDPRMRAYLGIRRRLAPLLENDRDQIELFTALLLSLPGSPVMYYGDEIGMGDNIWLEDRDAVRTPMQWSPDRNAGFSQADPGRLYLPAVMDPIYGFQAVNVEAQQKNPASLLHFTRKMLEIRRNHPVFGTGVYSELWSGNPAVLSFIREDGDDVMLCVNNLSKYPQPVELDLRRFEGMTPVEARGGVPFPQIGTLPYLLTLPGHGFYWFSINTR
>NC_013595.1|WP_012888365.1|1735928_1738208_+|ABC-transporter-permease
MSTTRASLRWIRADLRVRRGQALLTVLAVAGIVTALITSATLLEDGTNPWRGLFAESRGAHVWIHTKDAPDVTALSRLQGVTQVAGPYRTAPVMLAMDGRKSPVALRGMQAQPPSVAAPLIREGRWLRSGDVDGVVVERSFAEALDLRVGGPFTVTALSGASHPLVVVGLAETADQGFYPEWTPGLAWSLTTTLARVEPALGRSESVTGLRLADGEDTLPVVHGAVTLLAEKIQRMSTWREVRASMELDNRLLGLMLALFGVTGLVAAALAIVNVVGGRVLTQTRDIATLKSLGYTRSQIFGLLMAEHGALGLLGIAAGLVCGQIAASFALDGMPILPLSSLPLLAIVGGTAAVVLIAVALPAWRGCRTPPIPAAPAAPPKGHLSRVARLALLVRLPPALVLGTRDAFTRRVPAFLSIFGLAVPMMMITIGLGVWATLDDFLRHPEQVGQAAALTVRPDKLTPEDAARIVKADPEVQAAYPGSEVAALEPEQTRSVLARAVGTAAQPYPFSVVEGRMFSGRGEAVAGQGLLDLLGVKIGDRVRMTVGGTPLIVHIVGRVVEPDQDGEVLSLGLDSLAAKDAVPPQFYSLVLRPGADPAAVRARLLAASDEGLEVQRVVNPAERLEVIRVLIVALVVVLALIGLANLLTASALGLRDHALDLAVLKAMGLTPGQVAATLVTGTGLLVVLGVVAGTAAGASLVGGLIDLQGHTSGVGAGIGRTPSALTLLSAVLIAVGAALLVTLIPARRAVRAKIPVAVR
>NC_013595.1|WP_012888364.1|1735100_1735853_+|ABC-transporter-ATP-binding-protein
MSPPPPPIVSTVNLVKIYQNGGVPVPAVRGVDLQVEAGQFVAVMGPSGSGKSTLVHMIGGLDARTSGEIWLDGRRADTLSESAWALLRRQKIGFVFQFFNLVANMTVADNVELPALLAGSSPREARERREYLLGELGLADRADSAPSQLAGGEQQRVALARALANRPSLLLADEPTGNLDSRNTRDVLRLLSEVHRDGQTIIMVTHDARVASLADRVVSLLDGEIVDDGTVGPARRRPRATAGDVVELRG
>NC_013595.1|WP_012888363.1|1734597_1735104_+|PadR-family-transcriptional-regulator
MRQSLLALLAKEPAHGYELKQALEQIFGSAYPSPNIGQIYVTLSRLEKDGLVRVVDVEQSNRPNKKVYYLTAAGREALDVWVDDPTEGPRVRDEFFMKLVLAPMTGIADRMALINRQRRHYLALMRDLNELAERTDQGNRVALLLIEGAMLHLQADLDWLERCQEDLS
>NC_013595.1|WP_012888374.1|1747548_1748841_+|homoserine-dehydrogenase
MALKVALLGCGVVGSQVIRLMREQADDLAARVGAPLELAGVAVRRMGRKRDTDVDPALLTTDAEALVTRDDVDIVVEVIGGIEPARSLILAAMNSGKSVVTANKALLAEDGATVHGAARANNADLYFEAAVAGAIPLIRPLRESLAGDHVHRVLGIVNGTTNYILDKMDSGGASFSDALEEAQALGYAEADPTADVEGFDAAAKAAILAGIAFHSRVTAADVHREGITEITATDVASAKAMGYVIKLLAICARSEDGRSFGVRVHPAMIPRTHPLAGVREAYNAVFVEAQSAGQLMFYGAGAGGAPTASAVLGDIVAVARNLLAGTRGPEESTYAELAVHPMGETVTRYHVSLDVADKPGVLARVADMFAKQDVSIQTVRQEGHGDDAQLVLVTHRASDAALSATIESLREMDIVRDVVSVMRVEGEDTP
>NC_013595.1|WP_012888375.1|1749008_1749818_+|polysaccharide-deacetylase-family-protein
MKIVRWAAALPAALVALAVLQPVSHAESAKPPKKVTTVVSLTFDDGDATHAATARMLEKRGMRGTFYVNSDTIGRDAKLTRRELAAIAKAGHEIGGHTLTHIRLTELTRSAQRAQICDDRRALVAWGYRPTTLAYPFGSVDADAKAVARQCGYDAARRVGGLKDWGCRGCQAGEDLRPRDRYEIRTPGSIRDDTLPRQMRQQVLNAEKSGGGLVTLVFHQVCDGCGLYSVSPKVLDEFLGWLAARESHGTVVKTLHDAVGARYRPVPAE
>NC_013595.1|WP_012888376.1|1749966_1751670_-|glycosyltransferase
MNAPRIPGNDYGVLSPPAPGIWEPRLPVSVVIPARAQQEKLDLTLAALAAQTYPSHLLEVIVVDDGSAPPLRLPEIAPENTRLLRVPEGRWGIAWALETGTAAAGGEVIHRMDADIVAYRDHVESHMRWHHLADYLVVLGTLRFTAMAGTPPTASEVQIAVAKDRTDSLFDPDPDHGHDWIAELVATHRDFRDAPSPLLHRVHVGATVSLPAALLRAAGGMDTSLRLGEDTELGYRLTQTGAVFVPDAEALGWHLGTTTAMRRPGEVRRHNDPFIADRVPYRRNLRSDGGRQWLVPYVDVVVDALDASFEDVRASVDGALASTLPDVHVTLTGPWASLTGERRAPLDDPLLDLRLVRGQYAHDGRVSFAERVPPTSLPAPFRLTCPAGWVPGAESLAMLIRQADEDDEGLLLVALEENGSGVVAARLERTAAVARALRVARDGEPLDDVIADLYGATWLDAESWRFRPAAAAYPAWATDRNREAVRWRAEAESRRREAERAQRQVTALKSELRELRAAAAKSGRDTVRWKEKAEQRRLEAVALRQAQERSLLRRAARRLRGLTEGPR
>NC_013595.1|WP_012888377.1|1751666_1753589_-|glycosyltransferase
MSLLNDLVHAAGKRNGGRRVLVYCVGFETPDGPVPPGAIDLDGDLDGIPRAEEGAAEVLVLARTPTDLRRAATLHSLLPMATRVVVAVEETPHWYTAPVLSPTPAHRWRSLTELRVHQPRRPAWVVEAGFSKPTPAGRTLAATARAFAGHRMDAVAAPVAGLAGPGAAHWRPGDPNAAPAGVTGPVPGRFGARGGDLVLRTTDQDPPPWSGDETPVDRPVAELMSWERIGRPGGTRILENDLGDLSEPRTIPPVDDRSVNPMGFVTVPSLGTAELSVESGRWAIICEGRTLTTFGTSGCVTDVDVSRIRQVRGVHVDWRRSHSGPVAALRVVTGLAAAGVPLFSDVVPRWAGALGPELAGLITSVGDTGLGDDLEREEHSIRLRREALRTHGVRTRWEQLGAPAAARPLISVLLATRRPEMVRFALEQMAGQRGAEFEVILALHGIPAGHPDVAGAVASYDRPITVFEAPGETVFGAVLNEAAARASGSFLLKMDDDDWYGPDFVSDLLLAHSYSGADVVGMVPEFVYLASIGVTVHRDQVTEQITNFIAGGTIFAERSAFETVGGFRTLPGTIDAQFQHAVQAAGGQIYRTQGLGYILRRGNVANHTWREPIGTFLRRNKRQWRGFRPSALMELPAEAV
>NC_013595.1|WP_179949557.1|1753588_1755151_-|glycosyltransferase
MGGWEPRLRVSVVIPAHDCQEALDRTLAGLAAQSYPAHLTEVVVADDGSDPPLRIPAIAPANTRLVRVPDGRWGRGWARQTGAAAAAGDILHWVDSDMILDREHIEAHMRWHHLASYAVVLGDVRFTPEGAGPGAREVFAAVEAGDAERLFDGSVPHAWRAGVLDETRWLRDAGATAYRLHSGATTSVPMALLRSVGGVNTALHMGEDTDLGFRLAQAGAVFIPDPQARGWHLGPSTVMLREKEVHRHNWSVLPDLIPDLRWLRTHPRRHWLVPYVHVVVDARGASYEDVRASVDAALAGTVVDVAVTVVGPWAALTGGRRSSLDEPLLDLRLVRNLYTHEPRVSFTEETPLSSAPAPFRLTCPAGWALGADSLAELLKLAESEGYGLLSAVLDEGGEPETGVSVVRLERTAAFARAALVEDSGDLDGAVHELFGSFWVSADDFGVMAAGEAEPVAGDPAKWRAGAARWRREAERLEAEAESLRTETERLRAEVRELEDGRQRGPLREIIATAMRQGKAG
>NC_013595.1|WP_012888379.1|1755285_1755768_-|hypothetical-protein
MPTPRKLTLLAATIGSLVLIALALLAGAGTVSVTAAVVLGAMATVLAIQLLAIATVRRVDGKAQRIDTRVKRYEAEMAQVKAATERLDRRLEEIVGLLREHGSKRDEDLQAILASLGEDRLAAMPQRMEMEEMVHELLPRLAAVEARTEQDRPDGPEGKA
>NC_013595.1|WP_148269490.1|1756039_1757104_+|glycosyltransferase
MRSAAEAAAELSWTGQGWLAAGEPLGDRPDATEVTRLRELRALTVRWPSAEVPAGAITGLAAAGVPLHAAASPAWVEPGLARLLAAWTPEEGGGGPRSVTDLRREEHSVRLRRHGLRSRDAAATPAVSVVMSSMRPHLLGSALAQIARQRRVETEVLLALHGVPAGHEAVRRAVRDCGLPVTVIEADAETPFGEVLNLAASRAGGEYVAKWDDDDWYGPEHLADLLLARSYAGADIVGTAAEFFYLEPLNATIRRTDYTSEVWSDHVAGGTILLDRARYAELGGFPALPRGVDAGFLKAAHAAGARIYRTHGLGYVLRRSVSAEHTWRLSLAHFLRVATNQWRGFRPSLILEER
>NC_013595.1|WP_012888381.1|1757100_1758822_+|glycosyltransferase
MTARITGNDYRSLTPPELGAWTPSLRVSVVVPAYGGQDKLDLVLAGLAGQTYPAGLTEVIVVDNGSEPPLRLPELRPASTRLIVCPTPGRAHARNAGLGAATGDVIHWLDSDVVLDRRSVEAHMRWHHAAPYLVVTGYLRFTPAELPAPREVAAAADLAELFEPAEPHAWLVDLIERTDGLTDNPHRAFSLHVGGATSVNAALLAQAGPMDTELILGQDTEMGYRLAQAGAVFVPEPLARAFHLGPTMRMRDKAPIDRVSHAFVADRIPSYRWLRAHPARQWKVPYLEVVVGPAGRPDHAGEGGRGYGYDEVRATVDAVLAGTVPDVVVTVTGPWDRVRTEGRAPLRNPDLDLELIRGHYAHEGRVRFALDAPRTVRMAPPYPAEGGEAPEAGAAPPYRLRLPAGWVPGEDSLARLLDVAGDGGYGLVSALLAEGAGEGIVAARLERTAAFARAAIVRREGEDLDDAVEDTSGVLWVDGETYGFLPEARPIIGRRGAYRARTEAQAEIARLAKENERLRAQVTRWRDEAGRWRKSAVELRREVGGLRKELAAARKIVQYGLLSSVKRAIIRRR
>NC_013595.1|WP_081453057.1|1758882_1759776_-|SAM-dependent-methyltransferase
MARSCQLTDQFSKVSSIYDHANSGNIAPGERHVTDQIPTGIQTHIPNVARMYDYYLGGKDNFPADREAAEKVLTVVPEIRHSARSNRAFLGRAVDFVARSGIRQFLDIGAGLPTQNNVHQVATDARVVYVDNDPTVLVHGRAILGKNENVTIVHGDVRRPGEILEHPDIRAAIDFDQPVAVLLLAIMHFVPDEDDPEGIIATLRRALAPGSHLILSHVAIDARPEAAEGVTKVYDRASSPFVPRTGKEITRLFDGFDVVEPGIVNLPEWRPDPGAVVPYKGIGSYFLGGVGVVTEDG
>NC_013595.1|WP_012888383.1|1759774_1761100_+|MFS-transporter
MAASSSRRVLGLQLADGIGRGNMWACLTMAFAATMVISFLPAAQPYILSGVLGVAEDDQGKAVGLLGVAAEIAMIASLVWYGALADRFGRRPVVVAGFALCALGTALFPFAGNTTVLVALRVVFALGVAALSGMLSTVAVDYVRDGSRGRSYGLVGLFSGLGAMVAVLALVRLPVIFEDRGMAPVDAARVSFLIIAAVVLAVAALMWSTLSTVKVSATAERVPLTRLVKEGVALARDPGVALSYAAAFVARADLAVVAGFMSLWVFDYATGERGMSTAEALARGGAVVGIAQTVAVVAAPLFGWLGDRMRRQDVLILAQAVAAVSYLSTLLISDPLGSGMMMVAVLVGLGEIAAITTAGPLLAQQAPAAVRGSAYGVQTLCGAVGILVVSGLGGLLYDAWRPAAPFVISGVSGLLVVAFGLAVRRRVTPLSEERERVAAAA

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Crispr_ID: NC_013595_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_15

2131727-2131821

Orphan

Consensus_repeat	Method
CCCGTCCCGCCGAGGCCCGTTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_15

>merge|NC_013595|15|2131727-2131821|CRISPRCasFinder
ACGGGTCCGCCGAGGCCCGTCCCGCCGAGGCCCGTTCCACCTCCGGTCCCGCCGTGGATCCACTCGGGTCCGCCCATCCCGCCGCAACCCATCCC

>NC_013595|15|15|2131727-2131821|CRISPRCasFinder
ACGGGTCCGCCGAGGCCCGTCCC	GCCGAGGCCCGTTCCACCTCCGGTCCCGCCGTGGATCCACTCGGGTCCG
CCCATCCCGCCGCAACCCATCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012888711.1\|2125077_2126181_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176240
NC_013595.1\|WP_012888706.1\|2117631_2118456_+\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NC_013595.1\|WP_043651682.1\|2122836_2125074_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_013595.1\|WP_012888712.1\|2126397_2127657_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|379197
NC_013595.1\|WP_012888705.1\|2116732_2117524_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_013595.1\|WP_012888723.1\|2142361_2143111_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|187600
NC_013595.1\|WP_012888714.1\|2130550_2131300_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213186
NC_013595.1\|WP_012888726.1\|2146931_2147273_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319925
NC_013595.1\|WP_012888715.1\|2131903_2132305_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366264
NC_013595.1\|WP_012888709.1\|2122166_2122712_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182632
NC_013595.1\|WP_012888707.1\|2118482_2119928_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012888708.1\|2120048_2122070_+\|PASTA-domain-containing-protein	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012888722.1\|2141695_2142331_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NC_013595.1\|WP_012888717.1\|2134375_2136094_+\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379142
NC_013595.1\|WP_012888718.1\|2136230_2137376_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173841
NC_013595.1\|WP_012888725.1\|2145244_2146819_-\|acyl--CoA-ligase	unknown	unknown	gnl\|CDD\|223395
NC_013595.1\|WP_012888719.1\|2137372_2138347_+\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NC_013595.1\|WP_012888713.1\|2127837_2130534_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223487
NC_013595.1\|WP_012888720.1\|2138468_2139290_+\|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NC_013595.1\|WP_148269505.1\|2143112_2145230_-\|acetate--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|131764

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012888711.1\|2125077_2126181_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176240	cd08279, Zn_ADH_class_III, Class III alcohol dehydrogenase. Glutathione-dependent formaldehyde dehydrogenases (FDHs, Class III ADH) are members of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. Class III ADH are also known as glutathione-dependent formaldehyde dehydrogenase (FDH), which convert aldehydes to corresponding carboxylic acid and alcohol. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of an beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding.	2.40345e-146
NC_013595.1\|WP_012888706.1\|2117631_2118456_+\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	1.6287e-72
NC_013595.1\|WP_043651682.1\|2122836_2125074_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	2.82035e-91
NC_013595.1\|WP_012888712.1\|2126397_2127657_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|379197	pfam13458, Peripla_BP_6, Periplasmic binding protein. This family includes a diverse range of periplasmic binding proteins.	1.75541e-44
NC_013595.1\|WP_012888705.1\|2116732_2117524_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	4.67344e-28
NC_013595.1\|WP_012888723.1\|2142361_2143111_-\|glucose-1-dehydrogenase	gnl\|CDD\|187600	cd05341, 3beta-17beta-HSD_like_SDR_c, 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. This subgroup includes members identified as 3beta17beta hydroxysteroid dehydrogenase, 20beta hydroxysteroid dehydrogenase, and R-alcohol dehydrogenase. These proteins exhibit the canonical active site tetrad and glycine rich NAD(P)-binding motif of the classical SDRs. 17beta-dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens, and include members of the SDR family. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	7.30133e-95
NC_013595.1\|WP_012888714.1\|2130550_2131300_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	7.38296e-101
NC_013595.1\|WP_012888726.1\|2146931_2147273_-\|VOC-family-protein	gnl\|CDD\|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.49014e-15
NC_013595.1\|WP_012888715.1\|2131903_2132305_+\|hypothetical-protein	gnl\|CDD\|366264	pfam00720, SSI, Subtilisin inhibitor-like.	2.40615e-20
NC_013595.1\|WP_012888709.1\|2122166_2122712_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|182632	PRK10668, PRK10668, DNA-binding transcriptional repressor AcrR; Provisional.	1.39237e-10
NC_013595.1\|WP_012888707.1\|2118482_2119928_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.58424e-73
NC_013595.1\|WP_012888708.1\|2120048_2122070_+\|PASTA-domain-containing-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.0351e-74
NC_013595.1\|WP_012888722.1\|2141695_2142331_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	3.23517e-15
NC_013595.1\|WP_012888717.1\|2134375_2136094_+\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	8.26558e-15
NC_013595.1\|WP_012888718.1\|2136230_2137376_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	3.51099e-134
NC_013595.1\|WP_012888725.1\|2145244_2146819_-\|acyl--CoA-ligase	gnl\|CDD\|223395	COG0318, CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	4.86615e-101
NC_013595.1\|WP_012888719.1\|2137372_2138347_+\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	1.09686e-25
NC_013595.1\|WP_012888713.1\|2127837_2130534_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	3.92256e-76
NC_013595.1\|WP_012888720.1\|2138468_2139290_+\|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	6.90565e-57
NC_013595.1\|WP_148269505.1\|2143112_2145230_-\|acetate--CoA-ligase-family-protein	gnl\|CDD\|131764	TIGR02717, Uncharacterized_protein_MJ0590, acetyl coenzyme A synthetase (ADP forming), alpha domain. Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.	5.53699e-60

>NC_013595.1|WP_012888714.1|2130550_2131300_+|ABC-transporter-ATP-binding-protein
MSAALAVEAVSVSFGGVHALTDVSFEVPEGQVCGVIGPNGAGKTTLFDVISGLRRPTSGSVSVAGRDTTGVPAVRRARDGLRRTFQRTQVFGRLTVADNVLAAIEWRGGGGGLPADLAGGRARRRLERERRERVDEVLALCGLTELRDAYAAALPVGRRRLVELARALADTPSLLLLDEPTSGLDADQAARLEEIIRALDTTVLLVEHDMGFVMNVCDRLVVLDLGKVIASGPPAEIGDDPVVRAAYLG
>NC_013595.1|WP_012888713.1|2127837_2130534_+|ATP-binding-cassette-domain-containing-protein
MSELFGYIVSGLVTGAVFAVMASGLTLSYSATGVFNFAHGAVGFLAALLFFELNAGLGLPAWAAGLVAVGLFSPLLGYVLHRAMFRGLAQAGETAQIVGTIGLTIALPALGLWIVDLTAEPFGLPRADATSLPHGLGPYPAVTFTFGGVHLDSDQLITFAFAVLAAAGLWAFMRHTPYGLRMRASVDRRRLATLRGIDADASSAMAWTLGSALAGLAGVLAVSTLGLDSTAFTVMLFVSATAAVFGRLRSIPWTFAAGLGLGVVQNLVAGYADFAEDVTGLRTAVPVILLFVGLILLNRSRERVAGSAAEDAPPPDYLADLPMWRRRLPWALGLAALLAWTLTRSADDFYVSVVAQGLVLGLIFCSFVVVTGIGGMVNLAQASFASMAALTCGWAFSSGLPLPVAILLGVLGATAVGVLVALPALRLGGRILTLATLALALLADQVLFQIDAFSNGTIGWPLPAIGLGFTDTTDPRVRVVLLLALIGLVGLLVRNLERSASGRAVLAVRSAPAAATTSGISAPRTKIMLFALASGIAGLGGVLFATFKGSVTATDLPAFAGFVWLAVVVLQGVRRIGGAVLGGLIAAVFPELLSGWHISAHVGAILFGLGGMILARHPDGVLAQMAESRHRRRAGRQRREGAAAIQREASAVAAPVTAAAADPRPEEGRPVPEALFRLENVVAGYGDVTVLRGVDLAVRPGEVVALLGANGAGKSTTCAVAAGDLPVTAGRVILDGVDVTSWPAHRRAGAGVLLAPEGRGVFPGLTVDENLRTWLADPGPVYERMPQLARRRGIAAGALSGGEQQLLTLAPALVRPPRVLIADEPSLGLAPLVAEQVFEVFAELRARGVALLLVEEKATSALRLADTVVFMRLGRATWTGPRAEVDGARLAAAYLGVS
>NC_013595.1|WP_012888712.1|2126397_2127657_+|ABC-transporter-substrate-binding-protein
MRRQAVRLIGLVSAAALVAGCAAAQKNGTGAPGEAAGAAGVTGTTVTVGGVLTKTSASGYSTKDAEIGARARFQRANEAGGVHGRRIEFAGAEDDNQDAAKGDAAAKKLVQRDKVFALVPVHAPNFGGATFLEQQGVPWFGWATGPQWCGTETGFGYNGCLAPKPGAGSQTWWGNQMAELIGGSAGKSVYVQTTDSSGSKYGGKTISQSFQAAGFTLAGLNSGLPAAAPPPDWLPYVNKIMTSDGGEAPDLVVSIIAGTKFNTGLYAALKKAGYKGLLSDATSYDAAILKDPATARALEGVIAAPMFEPFESQAPEIAQLKADVEKAAPGTALTQHLAIGYWAADIFLKVLEQTGRDLTRERFLATANGSFTYENAGFGRIQYPKDHTEPNGCGALVKLEGGAFKVAKNMKCFDNVPLK
>NC_013595.1|WP_012888711.1|2125077_2126181_-|alcohol-dehydrogenase-catalytic-domain-containing-protein
MLMRAAVLTEFGAALEIREVDIADPGPGEVRVRIKASGVCGSDIKALDGKSPVVRQLPFVLGHESAGIVESTGAGVTGVRPGDHVIIAMNGACGRCRNCGGGRFHLCGGPARTAAIMGTMRDGTTRIKVDGADAKTMIGIGSFAEYAVVNEPMCVKIDRRAPFDTMCLLACGVVTGVGAVLNVAGVTPGSSVLVVGCGGVGLNVVQGAALAGATTIIGADVAESKLKLAGEFGATHTILSTDLPRQVGEIVRGGVDYAFDVTGVPSVLGDAFASTQPGGTTVMVGSPPQGRPLTIEPGLLFASRRLMGTQGGDAAPLRDLPMLAEQYLRGRLDLDRLVSERVPLEDVNEAIRHVREGAVARSVIVFD
>NC_013595.1|WP_043651682.1|2122836_2125074_+|MMPL-family-transporter
MSGLLGRLGSWCARHGRIVLALWVTAAVLLTAGSVVFAGPVSNNVTIPGTDAQRAHDLMRDGFGPGYDPGGTVQIVLYSPDGPLTSQRRVRAVHRAMDGIRRVPHVAEVQSPYRVGGLAPSMEIGLITVRLKGHDNGKLAETTRRLSEAAEPVRALGVEAVPADASTPADKEIKTGTSEIIGVVCALLVLLFAFGTLVAAMIPIFAALVSIATGLGVISLLGHVVDVPKQASIMATMIGLGVGIDYALFLLSRYRRLLADGLPVHDAVRRTVASSGGAVVFAGGTVIIALSALLLGGFPLLQTLGWITGISVVCAVLTSITLVPALLGLLGHRINALRLPFMGRRKTADEASGWSALGAWVAKRPWSVLVLSVAVLAALTAPALALKLGPLDDGYGDRDTAARRSYELMQAGFGPGINGPLVVVASLDEKVVDRDPAPAVLRLLKEKAGAVEGVAHVGEPVLNEGGTAVLVQAVTEYAPSDTRALEVVEDMRAIRVPGARVHVGGEVAAMSDASARIADRTPLVVGVVVLLSALLLLLAFRSPVVAIKAALMNLVSLGAAFGALSLVFSLGLGSGLVGMDPPVGADDSYLTTLFFTVPIDSYIPLMLFAVLFGLSMDYEVFLLTAVRQAYLRHGDNRRAVAEGLGTTGRVITSAALIMVAVFVAFIAYPDPMVKIFGVGLAVAVAVDATVIRGFLVPATMVLLGRFNWWCPGWLDRILPNLSIEGHEEESPAGEPRKELVVAGHG
>NC_013595.1|WP_012888709.1|2122166_2122712_-|TetR/AcrR-family-transcriptional-regulator
MTTLEHGYDTRSRILEAARQLFAERGYAATSLADIASAVGLTKTAVAYHFHPKDRLAAELIAPAAEDIVALFETGFDGEREFVEALVTFTVRHRAIVRLIMEDISGADDAPPGSPGEAIRAFRDAIYTRLASSDPDPGRRVRAWALLGALQSVVVKTIDLPEEVVREHLLTAASALYDLSA
>NC_013595.1|WP_012888708.1|2120048_2122070_+|PASTA-domain-containing-protein
MPHAQPLRTGDLDRLGEYVVVGRLGEGGQGVVYLGTHPATGSEPYAIKLLHGPLGEDEAVFLREVELAKQVARFCTAQVIEAGLAGDRPFIVSEYVDGPSLHREVRAGGPRGGGALERLAVGTATALAAIHRAGIVHRDFKPQNVLLGPDGPRVIDFGLARALDAGATQSGRGAGTPAYMAPEQVEGAEIRAAADVFSWGATVCFAANAQAPFGQDSIAAVLHRVLTAPPELGRLDGWLRELVAGCLEKDPRNRPTSRELLLTLLGDDDVRPAEPGSAPATGPVVPEVRAGPALSRSRPGRGPSWTSRPGRALSWTSAGPVPSGGSPPAPPFRDLGGAPDESTEARTRPGRAATRASVAVSGALLVSAAVLVAVLVPALSGNDEPVGPGRQGGAGRAAETPGARVESTPQPARAARPARHPAGTGVRSTSAPSPDPSTPPAVTGVAVPALAGLGRSEALNLLEEAGLAAGAITSVDSDLRVGQVLRSRPEARTVVARGTRVNLELSAGVAVPVLAGLHRRQAEAALARAGLVPGGITARCSAEPAGRVLASTPDAAERVSSGSAVALVVSRRGVEVPSVVGQREADARSALSGAGFAVRVRPRLVDDPSRSGVVLAQGGASGPCARPNAVVVITVGVEGQNGPGPGPDPDETTVPVDPTVTDGPGRARDVLSG
>NC_013595.1|WP_012888707.1|2118482_2119928_+|serine/threonine-protein-kinase
MSRPVPLRPEDPRQLGRYRLINRLGAGGQGVVFLAESPERPRVAVKLLHARLLDDERVRRRLVGEVEAVRRVAPFCTAQVLDADLDGDRPYIVSELVDGVSLQEHIAAEGPRVDGSLDRIAVGTATALAAIHRAGVVHRDFKPGNVLLGMDGPRVIDFGISRMMDATITTGKIPFGTPAYMSPEQIKGESAGPPADMFSWALTVAYAATGRHAFSAGSYHEVLARILYGRPDLGPLDGPLREIVVSCLAVEPGDRPVAEEVLRRLYGSTAASRPDGPPGAGPVSASGFPTAELPVTEDPVSGFPTAELPVTEDPASGFSTGELPVTGDPIVEPRAPEGSTAELPAVRTPRGRRRWLLIAAAGVAITAAVAGAAAAWLRDDFSYKGTWVGVADHATAERVFPVEVRFAEEAVSMRWGADLHCTARLSPTGAGAAYRLEQVRGRQCYPGTVVFSRDGADRLVFQVTRSGEAEARYSGAVTRSS
>NC_013595.1|WP_012888706.1|2117631_2118456_+|LLM-class-F420-dependent-oxidoreductase
MRLGVTMFATDRSMPVAELARAAEERGFASLYLPEHTHIPVSRRTAPAAGQAVLPEEYSRTLDPLVALSHAAAVTGRITLGTGIMLAAQREPIVTAKAVATLDHLSGGRVVLGVGFGWNVEEIEDHNVTYGSRRDVAREHILAMKVLWSEEEAGFTGRHVSFEPSWSWPKPVSGPPVYVGGAAGPKLFAHIAEYADGWMPIGGKGVRAALPALREACERAGREMAKVIPFGTLPSEEKLDYYAGMGVEEVVFSLPGAPADQVLPVLDGYAGFLR
>NC_013595.1|WP_012888705.1|2116732_2117524_-|alpha/beta-hydrolase
MAFTDLGDVRLFHTDDGAGDTTLLLVHGLGSDSHEWVHHIPSLAERYRVIAVDVRGHGYSSAPETGNTPRRMAEDLALLCLTLGVESCVAIGHSMGGQIVSHLAVEHPSLVRALVTVDPGYGFTGAVADSFPALIERMREDPVAAALRNDQWTSTRATPEWLREWHRRRILATPPHVLLQAFEAMFGGPDALGVRPNSDGYLSRRTCPVLTFWFDPAQAAWEADLFKDPHSRAVTWEGSGHRLHEERPGEFLLVVTYWLRSLA
>NC_013595.1|WP_012888715.1|2131903_2132305_+|hypothetical-protein
MAWPIPPRPYPVYPGYPGYPSYPSYPVVQDMLKDLLLTVEKLRDPRYTSRSVQLGCAPVSGTHPDAGGACAVLTPAYGDPAGIAPAPWGICAQVQDPVRATATGIWNGRYIRFEHTYSNPCTMRRATGPVFSF
>NC_013595.1|WP_012888717.1|2134375_2136094_+|trypsin-like-peptidase-domain-containing-protein
MWARFTAVTGLVLAGVLALPGVAMAKPKDLDIPVGTWLAARTHPAVQLTSVSYTADVAVPTPVANLEAIRGLTQQGVAAVQSGKISSDENSIYRWVVQQMAKEPGRYFSPGAPERVVEATAGGLCTGWWVTPDGYMVTAAHCVGQEESELAQTFATQALTKINEKDAADLVASLGDIASDDEIVRTAAKIFQVWNADNIKIRNVQSSLSLLQSLPGGGVDKTAKAVPIELVAKGTVYPGKDVAILKANGQNNLPTVPLGQDSDVRVGDTLYISGFPGTVTQTSIFNIESKLDPAFTEGPYNASRQTPEGVPYIQTQAPSYPGNSGGPVFSKDGNVIGILVGGLIQQDGGSTEGESFVLPVSIVREKLNEKNIKSAESVTTKAYNEALDLFFKNHYSDALPKFREVQALQPNHPYVAKYITDSQQAITAGKDESSSSILPWVLWGGGGLLVLFVLGTLGAVLRGKQRSKVPPSSFPPVPYGAQPGYLPPGQGQYGHPAQHGQPYGVPQQQPYPQRPPYPLPAAPEDTRAVHPQSPYGAPQQKPGPGANTRIAGLEAELEQLRRNMGQRPPDQR
>NC_013595.1|WP_012888718.1|2136230_2137376_+|acyl-CoA-dehydrogenase-family-protein
MDLDFTRAEQDFRAEVRDWLAGHVPGVPLPSMDTRDGFEAHREWERLLAGERLSVVSWPVEYGGRGASLVEWLIFEEEYWAAGAPGRVSQNGIFLLAPTLFSHGTAEQRERFLPGMARADDVWAQAWSEPEAGSDLAALTSRAERVEGGWRLHGQKTWSSRASYADWGFGLFRTDPASARHRGLTYFMFPLAGVTVRPITQLDGEHGFAELFFDGLFVPDDLVLGAAGEGWRIAMATTSSERGLTLRSPGRFLATADRLVRLARSTGADPVLADQVARAWLDAESYRLHTFGTARRLAAGEEIGSASSMGKVFWSELDVRMHALALRLLGERGLLDGGAPDAEEGGRWLDGYLFSLAGPIYAGTNEIQRNIIAERVLGLPR
>NC_013595.1|WP_012888719.1|2137372_2138347_+|acyl-CoA/acyl-ACP-dehydrogenase
MNFAFTDDQLALAAAVRQVLAAHCPAEAVRNGRTPAWSQLAEIGLFGLLVPQEHDGLGLGLVDAVLPFEETGRAALPGPVAETAVAAPLLLAGDPALGKLAAGSLRVSVRIGDQVYSPDADLADLLIVEREGVPYAVRPEAARLTPQSGVDRTRPLFGVEFGDATRLRTGIVPAVRAVTVAVAAQLVGAARHLLDTTVGYARTRRQFGAPIGSFQAVKHQLAEVAIAVEFAAPLVYAAALAVDRDLPSVDRDVSAAKAAAGEAAELAAGTALQVHGAIGYTGELDLGLWLARVWSLSAAYGDPGLHRARLRTAILGAPEMRRWP
>NC_013595.1|WP_012888720.1|2138468_2139290_+|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase
MRFGVPLGLVHPDAWRDVAVAADELGFESVWLPEHLVFATDLSLARYPGTDRPGISPATPLFDAPAYLCWLAGLTSRVRLGTAVHLYALRHPFVSARAFATLDRVSGGRAICGVGAGWYEGEWLAAGVDFGTRGPRLDEAIEVTRRLWSEPVVAHEGRFYGFPEVAFEPKPVQDRLPILAGGESGAALRRAARLCDGWISMPHSPDTIRPQLDRLAALRDDRPFSVTAHAYELAGPAEISRWEGLGVDRMIVRPWRRSRDAVAGLAAFAADCL
>NC_013595.1|WP_012888722.1|2141695_2142331_+|PaaI-family-thioesterase
MTTDLASTEDADALLAALAVLTRQARELVDAVVLTDVPESEIAAVTAELGVLTERLRARRRTSPQPFEIGPDGVPRHAGNAVTGSANPHALPLVVQTTPERTARAELTFRPTHEGPPASVHGGISAMILDHMLGHAVAVAGVAGMTGTLTVRYLRRVPYGEPLVATAEYTRSEGRKSWSEGRIALPDGTPLVEATGLFVTPRQWVENPLPG
>NC_013595.1|WP_012888723.1|2142361_2143111_-|glucose-1-dehydrogenase
MGLLDGKVALITGGARGMGEAHVRLFLEEGARVVFGDVLDDEGKALAEATGALFVHQDVTEPEDWRRAVSTTVETYGKLDILVNNAGILKFRRIADMTLDEYSRVLDVNLKGTWLGVKSVIEPMKAAGRGSIVNISSVEGFIGAEGMSAYAASKFGVRGVTKAAARELARFKIRVNSVHPGAINTSMVMDPEIAAEVDGEAFLKSMVIKRFAKPVEVSNVVAFLASDRASYCTGSEFTVDGGMLTGAGY
>NC_013595.1|WP_148269505.1|2143112_2145230_-|acetate--CoA-ligase-family-protein
MATAGPPPEHEVKALLREAGVAVPRGATAASAEGVAAAAGGLTPPLVLKAFGPGLVHKSDSGAVRLALAGPAEAAGAAAEMLGGLLAQGITPDGFLVEEQADPGVELIVGVVRDPGFGPVLLAGLGGVWTEALRDTAVRVCPVSEADARRMLASLRGSRLLRGYRGRPAADMDALVKLLLTIGGAGGLWERLELGEFELNPVIATGRGAVAVDARYIPGGPREEAPRPAPAAETDFTALFEPRAVAVVGASASRPNFGNMFLEFYRATGVPLVAVHPEADEIDGVPAVPTLADADADYALVAVPAGRCAEVVRQADGIPFVQVMSGGFGEAGAPELEAGLVRAAREAGTRLLGPNCMGVYSPRGGQTFIGGEPGPPGHVALISQSGGLAGEVVRVGERRGLAFSRVATVGNSADVTPAELLRWLATDEHTSVVGMYLEDPRGGRALFEALMSVRGRLPVVLLVGGRSAQGRRAAASHTGGMVGDDRVWRALAEQSGAALVTGQDDLIGVLSFFQSHARRLSALRTDPADGDPGGDPALLVIGPSGGASVLAADVFDAAGLSLDALPEEAEDGLKALGIGVGSSLANPLEIPVGPRGRPELAREAIAAIVARRPYPDVVAHVNVQSFFTYGSSAEPLYACARSLARAQEDLPEVRITLVTRNGECAPPGVEDGVRAIAAGAGIPVYRSMEAAAVAVAAAKRFTRGA
>NC_013595.1|WP_012888725.1|2145244_2146819_-|acyl--CoA-ligase
MARSPYGNYAYAILTANALRTPDRVALTYCGERSFTYSELDRIVDRRAHALTAAGIEPRRRVAALLNETLHVAEVYLAAAKLGAVTAALNPYWPVDTLREVVAHSGATAFVYDSTVEQVVAEIRPRLPDVTTWIKVGGPGEDVVDLDALTAAAPDGEFAPDGSGDDPLALYYTSGTTGLPKAAIHTHASSLATARIWLDVPRAEDSVLGTGAIIWGIGFPALVGPALYAGMRLVLEQDWGPANFLRVVPRERVTHVSQIPSFYAALLGSDDHEGVDLSSLRVIMLGGEALPATLLGRMRERLPGAGVYCYYGQTEAPYTCFGRVDDGSTPLGSSGRARTGNAVRITGPSGERVVGEVGEINLAGPHRMTGYDRLPEKTAEVLRGEWYVGGDLGVLAEDGNLTVLGRREDAILKGGAWTQPSAVEEAAVALDDVAEAGAVGVPEHVEGRDAAEQRILLAVVARSGHSLDPSKLAIALAESLPEHRRPDRIVVADELPHFQDASGGPGKLLRREIRERYRHLLEEA
>NC_013595.1|WP_012888726.1|2146931_2147273_-|VOC-family-protein
MTKLGNILIPVDDLDKAIALYSGALGLAVRFRDGDRFAALDGGGTTVALVAAGERVTGEVTAPSYKVGDVAAALRELTGAGAEVVREPETGPHEIRAVLRDPSGNVFVLYSSL

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Crispr_ID: NC_013595_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_16

2139412-2139504

Orphan

Consensus_repeat	Method
GGCATCCTCGTCCCTCCCGGGCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_16

>merge|NC_013595|16|2139412-2139504|CRISPRCasFinder
GGCATCCTCGTCCCTCCCGGGCCGGCCCTCCCGTCCTCGTGGACGGGCGCTCTCGCTGCCTCAGGGCAGGCATCCTCGTCCCTCCCGGGCCGG

>NC_013595|16|16|2139412-2139504|CRISPRCasFinder
GGCATCCTCGTCCCTCCCGGGCCGG	CCCTCCCGTCCTCGTGGACGGGCGCTCTCGCTGCCTCAGGGCA
GGCATCCTCGTCCCTCCCGGGCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012888711.1\|2125077_2126181_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176240
NC_013595.1\|WP_043651682.1\|2122836_2125074_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_013595.1\|WP_012888712.1\|2126397_2127657_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|379197
NC_013595.1\|WP_012888726.1\|2146931_2147273_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319925
NC_013595.1\|WP_012888723.1\|2142361_2143111_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|187600
NC_013595.1\|WP_012888727.1\|2147269_2147632_-\|Zn-ribbon-domain-containing-OB-fold-protein	unknown	unknown	gnl\|CDD\|224462
NC_013595.1\|WP_012888714.1\|2130550_2131300_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213186
NC_013595.1\|WP_012888715.1\|2131903_2132305_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366264
NC_013595.1\|WP_012888729.1\|2149885_2150506_+\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|376404
NC_013595.1\|WP_012888728.1\|2147663_2149712_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012888718.1\|2136230_2137376_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173841
NC_013595.1\|WP_012888713.1\|2127837_2130534_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223487
NC_013595.1\|WP_012888730.1\|2150505_2151297_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NC_013595.1\|WP_012888731.1\|2151299_2152529_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_013595.1\|WP_012888717.1\|2134375_2136094_+\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379142
NC_013595.1\|WP_012888725.1\|2145244_2146819_-\|acyl--CoA-ligase	unknown	unknown	gnl\|CDD\|223395
NC_013595.1\|WP_012888719.1\|2137372_2138347_+\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NC_013595.1\|WP_012888722.1\|2141695_2142331_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NC_013595.1\|WP_012888720.1\|2138468_2139290_+\|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NC_013595.1\|WP_148269505.1\|2143112_2145230_-\|acetate--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|131764

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012888711.1\|2125077_2126181_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176240	cd08279, Zn_ADH_class_III, Class III alcohol dehydrogenase. Glutathione-dependent formaldehyde dehydrogenases (FDHs, Class III ADH) are members of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. Class III ADH are also known as glutathione-dependent formaldehyde dehydrogenase (FDH), which convert aldehydes to corresponding carboxylic acid and alcohol. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of an beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding.	2.40345e-146
NC_013595.1\|WP_043651682.1\|2122836_2125074_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	2.82035e-91
NC_013595.1\|WP_012888712.1\|2126397_2127657_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|379197	pfam13458, Peripla_BP_6, Periplasmic binding protein. This family includes a diverse range of periplasmic binding proteins.	1.75541e-44
NC_013595.1\|WP_012888726.1\|2146931_2147273_-\|VOC-family-protein	gnl\|CDD\|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.49014e-15
NC_013595.1\|WP_012888723.1\|2142361_2143111_-\|glucose-1-dehydrogenase	gnl\|CDD\|187600	cd05341, 3beta-17beta-HSD_like_SDR_c, 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. This subgroup includes members identified as 3beta17beta hydroxysteroid dehydrogenase, 20beta hydroxysteroid dehydrogenase, and R-alcohol dehydrogenase. These proteins exhibit the canonical active site tetrad and glycine rich NAD(P)-binding motif of the classical SDRs. 17beta-dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens, and include members of the SDR family. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	7.30133e-95
NC_013595.1\|WP_012888727.1\|2147269_2147632_-\|Zn-ribbon-domain-containing-OB-fold-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	2.52613e-25
NC_013595.1\|WP_012888714.1\|2130550_2131300_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	7.38296e-101
NC_013595.1\|WP_012888715.1\|2131903_2132305_+\|hypothetical-protein	gnl\|CDD\|366264	pfam00720, SSI, Subtilisin inhibitor-like.	2.40615e-20
NC_013595.1\|WP_012888729.1\|2149885_2150506_+\|cysteine-hydrolase	gnl\|CDD\|376404	pfam00857, Isochorismatase, Isochorismatase family. This family are hydrolase enzymes.	3.04592e-24
NC_013595.1\|WP_012888728.1\|2147663_2149712_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.42553e-82
NC_013595.1\|WP_012888718.1\|2136230_2137376_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	3.51099e-134
NC_013595.1\|WP_012888713.1\|2127837_2130534_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	3.92256e-76
NC_013595.1\|WP_012888730.1\|2150505_2151297_+\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	5.21287e-74
NC_013595.1\|WP_012888731.1\|2151299_2152529_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	9.94657e-49
NC_013595.1\|WP_012888717.1\|2134375_2136094_+\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	8.26558e-15
NC_013595.1\|WP_012888725.1\|2145244_2146819_-\|acyl--CoA-ligase	gnl\|CDD\|223395	COG0318, CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	4.86615e-101
NC_013595.1\|WP_012888719.1\|2137372_2138347_+\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	1.09686e-25
NC_013595.1\|WP_012888722.1\|2141695_2142331_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	3.23517e-15
NC_013595.1\|WP_012888720.1\|2138468_2139290_+\|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	6.90565e-57
NC_013595.1\|WP_148269505.1\|2143112_2145230_-\|acetate--CoA-ligase-family-protein	gnl\|CDD\|131764	TIGR02717, Uncharacterized_protein_MJ0590, acetyl coenzyme A synthetase (ADP forming), alpha domain. Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.	5.53699e-60

>NC_013595.1|WP_012888720.1|2138468_2139290_+|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase
MRFGVPLGLVHPDAWRDVAVAADELGFESVWLPEHLVFATDLSLARYPGTDRPGISPATPLFDAPAYLCWLAGLTSRVRLGTAVHLYALRHPFVSARAFATLDRVSGGRAICGVGAGWYEGEWLAAGVDFGTRGPRLDEAIEVTRRLWSEPVVAHEGRFYGFPEVAFEPKPVQDRLPILAGGESGAALRRAARLCDGWISMPHSPDTIRPQLDRLAALRDDRPFSVTAHAYELAGPAEISRWEGLGVDRMIVRPWRRSRDAVAGLAAFAADCL
>NC_013595.1|WP_012888719.1|2137372_2138347_+|acyl-CoA/acyl-ACP-dehydrogenase
MNFAFTDDQLALAAAVRQVLAAHCPAEAVRNGRTPAWSQLAEIGLFGLLVPQEHDGLGLGLVDAVLPFEETGRAALPGPVAETAVAAPLLLAGDPALGKLAAGSLRVSVRIGDQVYSPDADLADLLIVEREGVPYAVRPEAARLTPQSGVDRTRPLFGVEFGDATRLRTGIVPAVRAVTVAVAAQLVGAARHLLDTTVGYARTRRQFGAPIGSFQAVKHQLAEVAIAVEFAAPLVYAAALAVDRDLPSVDRDVSAAKAAAGEAAELAAGTALQVHGAIGYTGELDLGLWLARVWSLSAAYGDPGLHRARLRTAILGAPEMRRWP
>NC_013595.1|WP_012888718.1|2136230_2137376_+|acyl-CoA-dehydrogenase-family-protein
MDLDFTRAEQDFRAEVRDWLAGHVPGVPLPSMDTRDGFEAHREWERLLAGERLSVVSWPVEYGGRGASLVEWLIFEEEYWAAGAPGRVSQNGIFLLAPTLFSHGTAEQRERFLPGMARADDVWAQAWSEPEAGSDLAALTSRAERVEGGWRLHGQKTWSSRASYADWGFGLFRTDPASARHRGLTYFMFPLAGVTVRPITQLDGEHGFAELFFDGLFVPDDLVLGAAGEGWRIAMATTSSERGLTLRSPGRFLATADRLVRLARSTGADPVLADQVARAWLDAESYRLHTFGTARRLAAGEEIGSASSMGKVFWSELDVRMHALALRLLGERGLLDGGAPDAEEGGRWLDGYLFSLAGPIYAGTNEIQRNIIAERVLGLPR
>NC_013595.1|WP_012888717.1|2134375_2136094_+|trypsin-like-peptidase-domain-containing-protein
MWARFTAVTGLVLAGVLALPGVAMAKPKDLDIPVGTWLAARTHPAVQLTSVSYTADVAVPTPVANLEAIRGLTQQGVAAVQSGKISSDENSIYRWVVQQMAKEPGRYFSPGAPERVVEATAGGLCTGWWVTPDGYMVTAAHCVGQEESELAQTFATQALTKINEKDAADLVASLGDIASDDEIVRTAAKIFQVWNADNIKIRNVQSSLSLLQSLPGGGVDKTAKAVPIELVAKGTVYPGKDVAILKANGQNNLPTVPLGQDSDVRVGDTLYISGFPGTVTQTSIFNIESKLDPAFTEGPYNASRQTPEGVPYIQTQAPSYPGNSGGPVFSKDGNVIGILVGGLIQQDGGSTEGESFVLPVSIVREKLNEKNIKSAESVTTKAYNEALDLFFKNHYSDALPKFREVQALQPNHPYVAKYITDSQQAITAGKDESSSSILPWVLWGGGGLLVLFVLGTLGAVLRGKQRSKVPPSSFPPVPYGAQPGYLPPGQGQYGHPAQHGQPYGVPQQQPYPQRPPYPLPAAPEDTRAVHPQSPYGAPQQKPGPGANTRIAGLEAELEQLRRNMGQRPPDQR
>NC_013595.1|WP_012888715.1|2131903_2132305_+|hypothetical-protein
MAWPIPPRPYPVYPGYPGYPSYPSYPVVQDMLKDLLLTVEKLRDPRYTSRSVQLGCAPVSGTHPDAGGACAVLTPAYGDPAGIAPAPWGICAQVQDPVRATATGIWNGRYIRFEHTYSNPCTMRRATGPVFSF
>NC_013595.1|WP_012888714.1|2130550_2131300_+|ABC-transporter-ATP-binding-protein
MSAALAVEAVSVSFGGVHALTDVSFEVPEGQVCGVIGPNGAGKTTLFDVISGLRRPTSGSVSVAGRDTTGVPAVRRARDGLRRTFQRTQVFGRLTVADNVLAAIEWRGGGGGLPADLAGGRARRRLERERRERVDEVLALCGLTELRDAYAAALPVGRRRLVELARALADTPSLLLLDEPTSGLDADQAARLEEIIRALDTTVLLVEHDMGFVMNVCDRLVVLDLGKVIASGPPAEIGDDPVVRAAYLG
>NC_013595.1|WP_012888713.1|2127837_2130534_+|ATP-binding-cassette-domain-containing-protein
MSELFGYIVSGLVTGAVFAVMASGLTLSYSATGVFNFAHGAVGFLAALLFFELNAGLGLPAWAAGLVAVGLFSPLLGYVLHRAMFRGLAQAGETAQIVGTIGLTIALPALGLWIVDLTAEPFGLPRADATSLPHGLGPYPAVTFTFGGVHLDSDQLITFAFAVLAAAGLWAFMRHTPYGLRMRASVDRRRLATLRGIDADASSAMAWTLGSALAGLAGVLAVSTLGLDSTAFTVMLFVSATAAVFGRLRSIPWTFAAGLGLGVVQNLVAGYADFAEDVTGLRTAVPVILLFVGLILLNRSRERVAGSAAEDAPPPDYLADLPMWRRRLPWALGLAALLAWTLTRSADDFYVSVVAQGLVLGLIFCSFVVVTGIGGMVNLAQASFASMAALTCGWAFSSGLPLPVAILLGVLGATAVGVLVALPALRLGGRILTLATLALALLADQVLFQIDAFSNGTIGWPLPAIGLGFTDTTDPRVRVVLLLALIGLVGLLVRNLERSASGRAVLAVRSAPAAATTSGISAPRTKIMLFALASGIAGLGGVLFATFKGSVTATDLPAFAGFVWLAVVVLQGVRRIGGAVLGGLIAAVFPELLSGWHISAHVGAILFGLGGMILARHPDGVLAQMAESRHRRRAGRQRREGAAAIQREASAVAAPVTAAAADPRPEEGRPVPEALFRLENVVAGYGDVTVLRGVDLAVRPGEVVALLGANGAGKSTTCAVAAGDLPVTAGRVILDGVDVTSWPAHRRAGAGVLLAPEGRGVFPGLTVDENLRTWLADPGPVYERMPQLARRRGIAAGALSGGEQQLLTLAPALVRPPRVLIADEPSLGLAPLVAEQVFEVFAELRARGVALLLVEEKATSALRLADTVVFMRLGRATWTGPRAEVDGARLAAAYLGVS
>NC_013595.1|WP_012888712.1|2126397_2127657_+|ABC-transporter-substrate-binding-protein
MRRQAVRLIGLVSAAALVAGCAAAQKNGTGAPGEAAGAAGVTGTTVTVGGVLTKTSASGYSTKDAEIGARARFQRANEAGGVHGRRIEFAGAEDDNQDAAKGDAAAKKLVQRDKVFALVPVHAPNFGGATFLEQQGVPWFGWATGPQWCGTETGFGYNGCLAPKPGAGSQTWWGNQMAELIGGSAGKSVYVQTTDSSGSKYGGKTISQSFQAAGFTLAGLNSGLPAAAPPPDWLPYVNKIMTSDGGEAPDLVVSIIAGTKFNTGLYAALKKAGYKGLLSDATSYDAAILKDPATARALEGVIAAPMFEPFESQAPEIAQLKADVEKAAPGTALTQHLAIGYWAADIFLKVLEQTGRDLTRERFLATANGSFTYENAGFGRIQYPKDHTEPNGCGALVKLEGGAFKVAKNMKCFDNVPLK
>NC_013595.1|WP_012888711.1|2125077_2126181_-|alcohol-dehydrogenase-catalytic-domain-containing-protein
MLMRAAVLTEFGAALEIREVDIADPGPGEVRVRIKASGVCGSDIKALDGKSPVVRQLPFVLGHESAGIVESTGAGVTGVRPGDHVIIAMNGACGRCRNCGGGRFHLCGGPARTAAIMGTMRDGTTRIKVDGADAKTMIGIGSFAEYAVVNEPMCVKIDRRAPFDTMCLLACGVVTGVGAVLNVAGVTPGSSVLVVGCGGVGLNVVQGAALAGATTIIGADVAESKLKLAGEFGATHTILSTDLPRQVGEIVRGGVDYAFDVTGVPSVLGDAFASTQPGGTTVMVGSPPQGRPLTIEPGLLFASRRLMGTQGGDAAPLRDLPMLAEQYLRGRLDLDRLVSERVPLEDVNEAIRHVREGAVARSVIVFD
>NC_013595.1|WP_043651682.1|2122836_2125074_+|MMPL-family-transporter
MSGLLGRLGSWCARHGRIVLALWVTAAVLLTAGSVVFAGPVSNNVTIPGTDAQRAHDLMRDGFGPGYDPGGTVQIVLYSPDGPLTSQRRVRAVHRAMDGIRRVPHVAEVQSPYRVGGLAPSMEIGLITVRLKGHDNGKLAETTRRLSEAAEPVRALGVEAVPADASTPADKEIKTGTSEIIGVVCALLVLLFAFGTLVAAMIPIFAALVSIATGLGVISLLGHVVDVPKQASIMATMIGLGVGIDYALFLLSRYRRLLADGLPVHDAVRRTVASSGGAVVFAGGTVIIALSALLLGGFPLLQTLGWITGISVVCAVLTSITLVPALLGLLGHRINALRLPFMGRRKTADEASGWSALGAWVAKRPWSVLVLSVAVLAALTAPALALKLGPLDDGYGDRDTAARRSYELMQAGFGPGINGPLVVVASLDEKVVDRDPAPAVLRLLKEKAGAVEGVAHVGEPVLNEGGTAVLVQAVTEYAPSDTRALEVVEDMRAIRVPGARVHVGGEVAAMSDASARIADRTPLVVGVVVLLSALLLLLAFRSPVVAIKAALMNLVSLGAAFGALSLVFSLGLGSGLVGMDPPVGADDSYLTTLFFTVPIDSYIPLMLFAVLFGLSMDYEVFLLTAVRQAYLRHGDNRRAVAEGLGTTGRVITSAALIMVAVFVAFIAYPDPMVKIFGVGLAVAVAVDATVIRGFLVPATMVLLGRFNWWCPGWLDRILPNLSIEGHEEESPAGEPRKELVVAGHG
>NC_013595.1|WP_012888722.1|2141695_2142331_+|PaaI-family-thioesterase
MTTDLASTEDADALLAALAVLTRQARELVDAVVLTDVPESEIAAVTAELGVLTERLRARRRTSPQPFEIGPDGVPRHAGNAVTGSANPHALPLVVQTTPERTARAELTFRPTHEGPPASVHGGISAMILDHMLGHAVAVAGVAGMTGTLTVRYLRRVPYGEPLVATAEYTRSEGRKSWSEGRIALPDGTPLVEATGLFVTPRQWVENPLPG
>NC_013595.1|WP_012888723.1|2142361_2143111_-|glucose-1-dehydrogenase
MGLLDGKVALITGGARGMGEAHVRLFLEEGARVVFGDVLDDEGKALAEATGALFVHQDVTEPEDWRRAVSTTVETYGKLDILVNNAGILKFRRIADMTLDEYSRVLDVNLKGTWLGVKSVIEPMKAAGRGSIVNISSVEGFIGAEGMSAYAASKFGVRGVTKAAARELARFKIRVNSVHPGAINTSMVMDPEIAAEVDGEAFLKSMVIKRFAKPVEVSNVVAFLASDRASYCTGSEFTVDGGMLTGAGY
>NC_013595.1|WP_148269505.1|2143112_2145230_-|acetate--CoA-ligase-family-protein
MATAGPPPEHEVKALLREAGVAVPRGATAASAEGVAAAAGGLTPPLVLKAFGPGLVHKSDSGAVRLALAGPAEAAGAAAEMLGGLLAQGITPDGFLVEEQADPGVELIVGVVRDPGFGPVLLAGLGGVWTEALRDTAVRVCPVSEADARRMLASLRGSRLLRGYRGRPAADMDALVKLLLTIGGAGGLWERLELGEFELNPVIATGRGAVAVDARYIPGGPREEAPRPAPAAETDFTALFEPRAVAVVGASASRPNFGNMFLEFYRATGVPLVAVHPEADEIDGVPAVPTLADADADYALVAVPAGRCAEVVRQADGIPFVQVMSGGFGEAGAPELEAGLVRAAREAGTRLLGPNCMGVYSPRGGQTFIGGEPGPPGHVALISQSGGLAGEVVRVGERRGLAFSRVATVGNSADVTPAELLRWLATDEHTSVVGMYLEDPRGGRALFEALMSVRGRLPVVLLVGGRSAQGRRAAASHTGGMVGDDRVWRALAEQSGAALVTGQDDLIGVLSFFQSHARRLSALRTDPADGDPGGDPALLVIGPSGGASVLAADVFDAAGLSLDALPEEAEDGLKALGIGVGSSLANPLEIPVGPRGRPELAREAIAAIVARRPYPDVVAHVNVQSFFTYGSSAEPLYACARSLARAQEDLPEVRITLVTRNGECAPPGVEDGVRAIAAGAGIPVYRSMEAAAVAVAAAKRFTRGA
>NC_013595.1|WP_012888725.1|2145244_2146819_-|acyl--CoA-ligase
MARSPYGNYAYAILTANALRTPDRVALTYCGERSFTYSELDRIVDRRAHALTAAGIEPRRRVAALLNETLHVAEVYLAAAKLGAVTAALNPYWPVDTLREVVAHSGATAFVYDSTVEQVVAEIRPRLPDVTTWIKVGGPGEDVVDLDALTAAAPDGEFAPDGSGDDPLALYYTSGTTGLPKAAIHTHASSLATARIWLDVPRAEDSVLGTGAIIWGIGFPALVGPALYAGMRLVLEQDWGPANFLRVVPRERVTHVSQIPSFYAALLGSDDHEGVDLSSLRVIMLGGEALPATLLGRMRERLPGAGVYCYYGQTEAPYTCFGRVDDGSTPLGSSGRARTGNAVRITGPSGERVVGEVGEINLAGPHRMTGYDRLPEKTAEVLRGEWYVGGDLGVLAEDGNLTVLGRREDAILKGGAWTQPSAVEEAAVALDDVAEAGAVGVPEHVEGRDAAEQRILLAVVARSGHSLDPSKLAIALAESLPEHRRPDRIVVADELPHFQDASGGPGKLLRREIRERYRHLLEEA
>NC_013595.1|WP_012888726.1|2146931_2147273_-|VOC-family-protein
MTKLGNILIPVDDLDKAIALYSGALGLAVRFRDGDRFAALDGGGTTVALVAAGERVTGEVTAPSYKVGDVAAALRELTGAGAEVVREPETGPHEIRAVLRDPSGNVFVLYSSL
>NC_013595.1|WP_012888727.1|2147269_2147632_-|Zn-ribbon-domain-containing-OB-fold-protein
MTSDTLTYWDACRRGELVIQRCTACARRVHLPAPDCPHCGGTDLPYEPVSGEGSVHTFTVVHRSFVPEFRGREPYVLAWIDLPEGVRAFGRIVDCAPERVRIGMPVCVTFVDDLPHWRPT
>NC_013595.1|WP_012888728.1|2147663_2149712_-|serine/threonine-protein-kinase
MVPGYHEVRELGAGGSGRVVLATYASTGAYVAIKYLNAAMRDDPWFVARFREEARVMVELRDPNIVRFYEYYEDVLEAAIVMELVDGVALRRILSGHGSTSPEAALVVLKGSLTGLASAHAAGIAHRDYKPENVLVQADGTSKLADFGIAARIGEPGTPSGTPSYMAPEQWAGEPAGAAGDVYAATCVFFECLTGRRPYEADHPAALMRRHRTAPIPLEAVPSSVRGLVARGMAKDPADRPPTARAFVADLEVAALSAYGPEWEQRGRRHLAELATLLALTFPLAKPSPRVSTSVARSVVGRMGGIRRPRLGPRVMAGAAVITVAVTVGLVAANRAPDRLSADTIFTPAPRSPEAGDTPAPPGRTSHARTSPGKDAGSPPPEPVTTPGPSRRAVTGRTVPSSASTDRPPTSESTGPRRPTPAPSRTPPRTAAPSPTGTPPPAHAVSGLAITGITAGGATIGLRASTTANVVLTVGFAEGRTPDRLTESPPRSLTLAGAGAYSPAVPHTFTPPACGQTLYRRVTVSTSPQAAGGPRTRTAEVRGDPCPAPSVESVDIVSFDGTTVRFRVRTGGTSAVTVKLGSAQKVVGGEGGFTSAVRTLELSGRTDYAREVAVEFADLPACGEYVQRVVTVATVPGGDMRSRDVRLPLPSCEPDPDPGPSAPDRPSEDGPGPDGSAEGGIL
>NC_013595.1|WP_012888729.1|2149885_2150506_+|cysteine-hydrolase
MPIDLRSLAAPGHSAVLVMEMQRGVVGDLAKFPDLVEVCARRDVVANASSVLAAARAAGIPVIHCTAAFRADRAGSHTGNCPFITALLKDPAHMLEGTGAIEVLPALLDPADLESRRYHGFSPFTGTSLDMTLRSLGVSAVVAVGLSLNLGIPGLALEAVNLGYRVAVVTDAVAGTPDDYAQAVLDNTVGLLAARVTAADLVEVWR
>NC_013595.1|WP_012888730.1|2150505_2151297_+|SDR-family-oxidoreductase
MEGLRLDGRTAVVTGGAGAIGAAICRDLASLGARIVVADVDGQGATALADELNSESLGLGTRVGAPSGPRAPARALRVDLADPGSVTEFCGDAGPVDILVHNAGVSVVEPFVGSDPAAWDLMWQVNLRGPMLLTRLLLPGMTERGWGRLVFISSDGARAGSGGEGAYAATKAGLFGLAKTLAREAARAQVTSNVVCPGPTDTPMLRRVDAEKPGLVDKLARSVPLRRLGVPEDVAGLVAYLCTDRAAYITGQVLSVSGGITMH
>NC_013595.1|WP_012888731.1|2151299_2152529_-|serine-hydrolase
MTVVHGQCDPRFSRVREVFGRHFAEGEELGAAFTVFLDGEPVVDLWGGVADRHSGRPWERGTPALTYSCTKAVTATAALLLAERGLLDVTAPVADVWPEFARHGKERITVEHLFTHQAGLPTIETPVPPEEFEDQAAIADRLAGQAPIWEPGTAHGYHALTYGFLLGEVIRRVSGKSPGEFVAAEIAEPLGLELWFGAPEEVAARAARLSAGRRQGPAEAGAAPAGAAADAVPRVSAAAELPGRGNPVEEMSRAVLDRDSLMNRALGNPPIHRLQGGANHPVILRSGWPAIGVVATARGLAGFYRDLVAGRILRPETLEDALRRRVTGPDRVLIIDSSFGLGYMRPALTFLTPSKGAETAFGHTGLGGFLGLGDVEHGLGMGYTMNKMADAVSGSLRAYRLAEAVYGSI

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Crispr_ID: NC_013595_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_17

2342507-2342729

Orphan

Consensus_repeat	Method
CCGGCCCCGGTACGGCAGGGCGGAC	CRISPRCasFinder

4 spacers

The CRISPR arrays of NC_013595_17

>merge|NC_013595|17|2342507-2342729|CRISPRCasFinder
CCGATCCCGGTACGGCGGGGCGGCTGGGGGTCGGTCCGGGCTCCGGCCCCGGTACGGCAGGGCGGACAGGAGCCCGGGACGGTGCCGATCCCGGCGCGGCCGGGCGGACGGATGTCCGGAACGGTGCCGGCCCCGGTACGGCGGGGCGGACGGGAGCCCGGGACAGCGCCGATCCCGGCGCGACCGGGGCGGTAGGAGCCGGGGCCGTCACGGCGGAGCGGTC

>NC_013595|17|17|2342507-2342729|CRISPRCasFinder
CCGATCCCGGTACGGCGGGGCGGCT	GGGGGTCGGTCCGGGCT
CCGGCCCCGGTACGGCAGGGCGGAC	AGGAGCCCGGGACGGTG
CCGATCCCGGCGCGGCCGGGCGGAC	GGATGTCCGGAACGGTG
CCGGCCCCGGTACGGCGGGGCGGAC	GGGAGCCCGGGACAGCGCCGATCCCGGCGCGACCGGGGCGGTAGGAG
CCGGGGCCGTCACGGCGGAGCGGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012888911.1\|2343901_2345416_-\|glycoside-hydrolase-family-3-protein	unknown	unknown	gnl\|CDD\|224389
NC_013595.1\|WP_012888919.1\|2356050_2357505_-\|glycoside-hydrolase	unknown	unknown	gnl\|CDD\|366376
NC_013595.1\|WP_012888905.1\|2337097_2337889_-\|Fpg/Nei-family-DNA-glycosylase	unknown	unknown	gnl\|CDD\|223344
NC_013595.1\|WP_012888900.1\|2333153_2333924_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379173
NC_013595.1\|WP_012888899.1\|2330556_2333073_+\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|224588
NC_013595.1\|WP_012888902.1\|2335428_2336034_+\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|223632
NC_013595.1\|WP_012888918.1\|2355302_2355983_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012888901.1\|2333993_2335403_+\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl\|CDD\|273453
NC_013595.1\|WP_012888916.1\|2352754_2353990_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|366359
NC_013595.1\|WP_012888906.1\|2337899_2338349_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NC_013595.1\|WP_012888914.1\|2346995_2351306_+\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
NC_013595.1\|WP_012888904.1\|2336741_2337101_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_013595.1\|WP_012888903.1\|2336030_2336534_+\|nicotinamide-nucleotide-amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|234789
NC_013595.1\|WP_012888908.1\|2340379_2341558_+\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NC_013595.1\|WP_012888912.1\|2345587_2346712_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380454
NC_013595.1\|WP_012888913.1\|2346708_2346999_+\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
NC_013595.1\|WP_012888917.1\|2353986_2355309_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|223727
NC_013595.1\|WP_012888907.1\|2338369_2340061_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380462
NC_013595.1\|WP_012888910.1\|2343062_2343764_+\|PIG-L-family-deacetylase	unknown	unknown	gnl\|CDD\|376836
NC_013595.1\|WP_012888915.1\|2351289_2352777_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012888911.1\|2343901_2345416_-\|glycoside-hydrolase-family-3-protein	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	1.28473e-75
NC_013595.1\|WP_012888919.1\|2356050_2357505_-\|glycoside-hydrolase	gnl\|CDD\|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	5.46064e-74
NC_013595.1\|WP_012888905.1\|2337097_2337889_-\|Fpg/Nei-family-DNA-glycosylase	gnl\|CDD\|223344	COG0266, Nei, Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair].	3.2662e-63
NC_013595.1\|WP_012888900.1\|2333153_2333924_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379173	pfam13413, HTH_25, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	5.90147e-20
NC_013595.1\|WP_012888899.1\|2330556_2333073_+\|DNA-translocase-FtsK	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	7.98545e-149
NC_013595.1\|WP_012888902.1\|2335428_2336034_+\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl\|CDD\|223632	COG0558, PgsA, Phosphatidylglycerophosphate synthase [Lipid metabolism].	4.68547e-34
NC_013595.1\|WP_012888901.1\|2333993_2335403_+\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	gnl\|CDD\|273453	TIGR01125, Ribosomal_protein_S12_methylthiotransferase_RimO, ribosomal protein S12 methylthiotransferase RimO. Members of this protein are the methylthiotransferase RimO, which modifies a conserved Asp residue in ribosomal protein S12. This clade of radical SAM family proteins is closely related to the tRNA modification bifunctional enzyme MiaB (see TIGR01574), and it catalyzes the same two types of reactions: a radical-mechanism sulfur insertion, and a methylation of the inserted sulfur. This clade spans alpha and gamma proteobacteria, cyano bacteria, Deinococcus, Porphyromonas, Aquifex, Helicobacter, Campylobacter, Thermotoga, Chlamydia, Streptococcus coelicolor and Clostridium, but does not include most other gram positive bacteria, archaea or eukaryotes. [Protein synthesis, Ribosomal proteins: synthesis and modification].	1.07804e-129
NC_013595.1\|WP_012888916.1\|2352754_2353990_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|366359	pfam00891, Methyltransf_2, O-methyltransferase. This family includes a range of O-methyltransferases. These enzymes utilize S-adenosyl methionine.	1.33546e-14
NC_013595.1\|WP_012888906.1\|2337899_2338349_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	7.80607e-41
NC_013595.1\|WP_012888914.1\|2346995_2351306_+\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NC_013595.1\|WP_012888904.1\|2336741_2337101_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.37379e-07
NC_013595.1\|WP_012888903.1\|2336030_2336534_+\|nicotinamide-nucleotide-amidohydrolase-family-protein	gnl\|CDD\|234789	PRK00549, PRK00549, competence damage-inducible protein A; Provisional.	2.96434e-53
NC_013595.1\|WP_012888908.1\|2340379_2341558_+\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	3.04523e-38
NC_013595.1\|WP_012888912.1\|2345587_2346712_+\|hypothetical-protein	gnl\|CDD\|380454	cd19531, LCL_NRPS-like, LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar domains including the C-domain of SgcC5, a free-standing NRPS with both ester- and amide- bond forming activity. LCL-type Condensation (C) domains catalyze peptide bond formation between two L-amino acids, ((L)C(L)). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). In addition to the LCL-type, there are various subtypes of C-domains such as the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. Streptomyces globisporus SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. An HHxx[SAG]DGxSx(6)[ED] motif is characteristic of LCL-type C-domains.	8.52722e-31
NC_013595.1\|WP_012888913.1\|2346708_2346999_+\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	8.82445e-18
NC_013595.1\|WP_012888917.1\|2353986_2355309_+\|FAD-dependent-monooxygenase	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	6.56799e-46
NC_013595.1\|WP_012888907.1\|2338369_2340061_-\|hypothetical-protein	gnl\|CDD\|380462	cd19539, SgcC5_NRPS-like, SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- bond forming activity and similar C-domains of modular NRPSs. SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. This subfamily also includes similar C-domains of modular NRPSs such as Penicillium chrysogenum N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase PCBAB. Condensation (C) domains of NRPSs normally catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.	2.66929e-17
NC_013595.1\|WP_012888910.1\|2343062_2343764_+\|PIG-L-family-deacetylase	gnl\|CDD\|376836	pfam02585, PIG-L, GlcNAc-PI de-N-acetylase. Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyzes the second step in GPI biosynthesis.	2.37557e-10
NC_013595.1\|WP_012888915.1\|2351289_2352777_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.2123e-60

>NC_013595.1|WP_012888908.1|2340379_2341558_+|ROK-family-transcriptional-regulator
MERRPGVPRLLREINDRAALELLLDSGPLTRGQIGELTGLSKVTASQTLARLEERGLVEVAGEQAGGRGPNAALYGIIPSSAYVAGLDVGPEFVTTAIADIHGEIVAEVTVAPNGHDDPVALVHSAVVKACRSAKVALSKLRAVVIGTPGVVDPRTGDVRFSFDLPGWHEGIHEALARDLRRDIKIENDVNLVAVAERTLGAARGVDDFVLLWVGRGIGLGVVLGGRLHRGRSGSAGEIGYLPVPGVPLAADVRAVPGRLPSLAGGLQSLVSAEAVAELAATHGFEGGSAAECVAAAVEAGKRGEPLLDEIAERLALGVASVSVVLDPGLVVLAGEVSQAGGGALTSRIEEAVARICPVRPQVVASEVEGNPVLRGAVLAALEQAREEIFAP
>NC_013595.1|WP_012888907.1|2338369_2340061_-|hypothetical-protein
MDTIIRIAADYAGRPTRNGPVTMGQANMARCVLRDPPLHMNFRVTKRLPAGTTFAAVTVAVGRLLSRHESLRATIRAGVQHVPGAGVFPIEVHGAATDGAGPEAAEHALDGLAEEVGLRMQGTRFDVEAELPIRIAVIAERDVPRRVIFVLPHTSVDAIGLATVMREWERLIRGDAVPAPCPTQPLELAVAEGTPLARRRTEAALRHWETQLRRVPQSMFAIDEVADADAIRPRLRVRSAVAGEALGAVASRTGASRSVVTLAALGMLIGLRSSQRSCVIASLSSNRVRPELRDYVGPLAQDALMAADLDVPTFDEAVRRFRGASLAGYQHSRFDSTALWEVIEGVNAERGVNFARDCVFNDMSGVTVADREPPPAADVECDWLPEASLPAHLALWANRLEDEVDLTFWIDPRVMSRQEAEGFGTGLVRLLIEAGDRVIPAAEIPAVSGVAPAGHGPGWVHADSCWVSLDAVARLVGEAVGGRPHRVIYGADGRLTCHVTSGTPEEIHAACLALLPGRTSAMTPHHYVVHRAAPGDTWLDGPVVTEGDGRRLDSFLTPRISSQ
>NC_013595.1|WP_012888906.1|2337899_2338349_-|Rrf2-family-transcriptional-regulator
MRLSARVDYALRAAAELAAAGEGPTTVGELAKEQDMPPKYLENILLQMRRAGLVRGQRGPEGGYVLARPAAEITLADVIRAVDGPLANVRGERPEHVDYRGPAESLQQVWIALRASERAILEEVTLDSVATGALPERVRQLAADPAAWD
>NC_013595.1|WP_012888905.1|2337097_2337889_-|Fpg/Nei-family-DNA-glycosylase
MPEGDVVYRTARRLGEALDGRILTRSDFRVPRHATADLTGRAVLETVSRGKHLLTRVDGGLTVHTHLRMEGSWRISPAGRRPPSGDVVRLVLANADWQAVGVRLGMVDLVATGEEHRLVGHLGPDPLGPDWDPAEAVRRLMGSPGLTIGEALLDQRNLAGIGTVYRAETLFLAGVSPWRPVGEVEDVRRIVALAQRLLHANGERERRVTTGDARPGRDTWVYGRAGRPCLRCGRRISRGEMGAQPQERLIFWCRHCQPGEPTG
>NC_013595.1|WP_012888904.1|2336741_2337101_+|helix-turn-helix-transcriptional-regulator
MVLLRQLLGDVLRRLRVRQSRTLREVSTLARVSLGYLSEVERGQKEASSELLASICGALGVPLSQVLREVSDQFALAELQHAPVLAGDVPERERLPITETVPGSLPESVFPEVNDMVAA
>NC_013595.1|WP_012888903.1|2336030_2336534_+|nicotinamide-nucleotide-amidohydrolase-family-protein
MSHRLLAATHVLSLLVRKGETVAVAESLTAGLIGAALTGPAGASAAFVGGVVSYATELKERLLGVPAELLEREGAVHPQVAAAMATGVRRLTGSTYGLAATGVAGPDPQDGRAVGTVHLAVSGPDGRVWHRDLRLDGTREEIRQSTVNEAVDLLQGVLEANLGEHSG
>NC_013595.1|WP_012888902.1|2335428_2336034_+|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MTNTPETGTDQTAAATRPKVSVWNIANVVTVIRLAMVPFFAFCLFLPGPGWRVTALVVFLVASLTDLLDGELARRYGLVTDFGKIADPIADKALIGAALISLSALDELAWWVTIVILGRELGVTLLRFAVIRHGVIPASYGGKVKTVLQIAAIVSYMWPGVPEPIRWTVMGAAVVVTVGTGLDYVIRAVKLRQVAKRARAQ
>NC_013595.1|WP_012888901.1|2333993_2335403_+|30S-ribosomal-protein-S12-methylthiotransferase-RimO
MSSRRTASLITLGCARNEVDSEELAARLEAAGWQVGDDDPDVIVVNTCGFIDSAKKDSIDTLLAAADSGAKVVAAGCMAERYGDQLADALPEAAAVISFDDYTQIGTRLDDVLEGKPLVPHSPRDRRTLLPISPVERAAAPKANIPGHGELPDGLAPASGPRPLRKRLGDGPVASLKLASGCDRRCTFCAIPAFRGAYVSRSPEELVSEAAWLAGQGVKELVLVSENSTSYGKDLGDLRALEKLLPSLAATEGIERVRVSYLQPAELRPGLLEMIASTESVAPYFDLSFQHASGSVLRRMRRFGDPRRFLDLLESVRATAPEAGVRSNFIVGFPGETEEEFAELTAFLQEARLDVIGVFGYSDEDGTEAASLPGKLDQETVDARVAALTELAEELMAQRAEERIGTEVDVLIEEDLGDGGYEGRAAHQGPEVDGSVTVQGIGLVPGQIVRAVVVDSEGVDLIARIKAAS
>NC_013595.1|WP_012888900.1|2333153_2333924_+|helix-turn-helix-domain-containing-protein
MSIGSDLAEARRAAGLTVGQLSARTRVREALIHAIERDDFSQCGGDFYARGHIRNISKVVGLDPETMVHKYDESHGGVPLPVRAASVFQADTPIKIRESRSPNWTTAMAVALAIVVVFGVVKMMGGGDTPTADVRPASVPAVPPPAASPTGPAATPNPSRRAASLATGKRGDLVVFQVKAKRSSWLDVTETGGRKLFSGMLEAGKTSVWKAKKGVKVTFGDGGAFLLQVNGKNLGTPGPSGQVLNRSYGASAPQPG
>NC_013595.1|WP_012888899.1|2330556_2333073_+|DNA-translocase-FtsK
MATRTSKGASGKTPAKGSSGRSGSPSPRRAPARRAANARAKTTAQARRPVTPNQDPIGWVFTMIGKLFMGIWMLLAGGIGSAARALGQNARELDPVHRRDGLGLAVFSGAIVLAAMTWRESTGTVSAVVNAVMHGVFGSLAWLIPILLALLAWRLLRHPDQNADTGRMSIGWSALTVGVLGVVHVVHDTPYPSGGGSDGMDKVSAAGGMIGFVVSAPPASILPAFVTIPLLLILSGFGILVITATPVHRIPERLAEIKHMLFNRDLPAKPREPRKRPSRKKPDEGAEVGDHIKPYDTPVVSESQNKQGAEHSPEIVPGLADEEEAAVHRAEPPEPTPAPRKVEQLVLSPQAGPYTLPESQLLRPGSAPKPQTKANTVVVNALTSVMEQFAIDAQVIGFTRGPTVTRYEIELGPAVKVEKVTALTKNIAYAVKSADVRILSPIPGKSAIGVEIPNTDKDLVSLGDILRSQVAQADQHPMIVGLGKDVEGRTIVANLAKMPHLLIAGATGAGKSVCVNGLISSILMRATPDEVRMVLVDPKRVELSVYEGIPHLITPIITNPKKAAEALEWVVGEMDRRYDDLAASGFRHVDDFNKAVRAGKLVPPPGSERVYQPYPYLLVIVDELADLMMVAPRDVEDSIVRITQLARAAGIHLVIATQRPSVDVVTGLIKANVPSRLAFATSSLADSRVILDQPGAEKLVGQGDALFLPMGASKPMRLQNAFVSEKEINEVVAHCKAQMQVEYRDDVAAAATAKKEIDEDIGDDLDLLIQAAELIVTTQFGSTSMLQRKLRVGFAKAGRLMDLLESRNVVGPSEGSKAREVIVKPDELAGLLADLRGE
>NC_013595.1|WP_012888910.1|2343062_2343764_+|PIG-L-family-deacetylase
MSWRTIVVSPHFDDAVLSVAGVLARDEGPAVVVTALGGAPGEEISAWDRLCGFASAEETARERRAEDARACEILGVDQVALAHPDAPVAGLRLRELEGFLTGHVTPETRVLIPMGIGNADHEAVRDQALDTLRKAGARQPWVYADLPYAAAVREWGTASADQALAAKPPVRALAERHRIRPELRIRLEGDEWTAKRRAVLAYASQIAPLACDYGEFLAMPGPLQHELVWAVDD
>NC_013595.1|WP_012888911.1|2343901_2345416_-|glycoside-hydrolase-family-3-protein
MIVRGGLSGASPELAGLADAVLQPGFVGVEVPDWLRRRLGEGLGGVALYSRNLVDSAQVRALTAALRAENPDVVIATDEEAGDVTRLEALTGSSRPGNLALGAVDDPELTELVARGVGRDMADAGITLNYAPVVDVNSDLDNPVVGTRAFGADPWLVARHARAWVTGLQSAGVAACAKHFPGHGATAVDSHNDLPTVSYSAEELAATTLPPYRTAIEAGVRAVMTGHLLVPAYDPDFPATMSSRILVGLLREELGFDGLIVTDGVEMPSVAERYGVTGAAVRALAAGADAVCVGGERKGAGVVGFMRNAIMAAVIDGTLPEERLAEAASRVRRLAAWSAEQRQVAWATDQAALTPAGLTAARRAVRVRGEGLPLTSAPQVIEFVSETNIAIDRATPWGVATPLAALLPGTTTVRLGAEDQVPPVPDGRPLVIVVRDAHRHAWVSARLDALLSRRPDAVVVEMGLPGPGTPGGTHITTHGATSACGQAAAELLAGRPSLTPTGPR
>NC_013595.1|WP_012888912.1|2345587_2346712_+|hypothetical-protein
MSHASFDLRGIPLVLHLNGPLDVPALLGACAAVAARHPVLGRVRVSRVDSSARRYPEVAAAEVTRPFDPDRGPLARFTLVALGPDRHRLIFTAHGRVFDGGSKDVLLRDLADAYFSRAALPGLAPPYGEQPQADGAVAFWRERERGPAELLLPGLRATPAGTGPGEIVEMVLGGAEFEGVAAAAAALEATRFELLVAVLGVLLRRHGTTASPLALDLGTRTGETRHHIGNFVAEVPFVPHPELDGDLPAYLRTVQAELRELYRFRYAPPREASRPVLLSYRRRASAPDFPGIGAGVEWTVFNGTARRALHVQAVDGDLSLTLGLRFNPTAIDHDDVAGVAGYLRVLLRAIAAEPQVKIADLPAPPHPEPDEELQ
>NC_013595.1|WP_012888913.1|2346708_2346999_+|non-ribosomal-peptide-synthetase
MNDLFSPAPDATLERPEQEDPVITQVREIWEEILRIDDIGLEEDLYDLGGHSLTITQIIARTRRRLGVEVSLDVFFDNPTIAGLAEEVTRLRGELA
>NC_013595.1|WP_012888914.1|2346995_2351306_+|non-ribosomal-peptide-synthetase
MSALSYAQERLWFLDRLTPGDGTYNMVVCERLTGPLDAGALARALSEIVARHEALRTVFPQAGGAPVALVLDPAPVEIERLDLTGGPLAGQSLEELLAERSNRPFDLAEGPLLRASLLRTGPGEHVLLLVVHHIAGDAWSIEQVMFAELATLYAAFTTGLPSPLAPPARQYRDHVRMQREHSADVAGLLRELDDVPALELPTDRPRPAVQTTNGDLVIHRIPLELWQRVTGLARAERCTPFMTLLAAYQVLLSRYSGQEDFCVGTPVAGRDHEEFEQVFGIFINTLALRADLAGDPTFRETLKRVRRRAFTMYGHAAVPFERVVGELRLDRDPARTPLFQTMLMLGNPDSGALTLDGLRTEPVLSGLAGAKFDLALDVIVYPTHVQLMFSYNTDLFDRSTVERMGAHFGTLLHSVVSEPGRRLSELEILPAAELAAVLGDPPEDLAWDPGALLLDHLIARQAARTPDAPAVVVPGTAGDRGASAGTVLTYGELDRASTAVAGRLRLLLAQAAPSGEPADRGARVALGLTAGPEAVVALLGILKAGAAYVPLDPAQPAERLAYLLADSGAAAVIAEEAGFAGFTGPIVTRADLAFWTTDRTAAAPKAAARHPDQAAYVIYTSGSTGRPKGVVVGHRTLSHLARSFRDLHGFGPGERVLMVPPLSFDASAGDVFPALISGAALVLHPDPASLTGPALVDLCAEHSITMVDTASALWQQWVDTLDAAAGGGDVPLTAMMVGGESVPLERLRVWAGLTGGRVAFYNHYGPTEATVCATAYRTVDGAELGAATHLPIGTALPHTRVYVLDRHGNPAPIGVPGEVHVGGECLAHGYLGRPGLTAERFLPDPFSPRPGARMYATGDLARFRPDRNLEFLGRTDRQVKIHGNRIEPGEVEAACLAHPGVREAVVTAGARRLVAYLVGEPLTAAALRAFLADRLPGYMIPGAVVMLAALPLTSHGKIDFRALPEPDGDGGGVPYEPPREGTEQVLAAIWAEVLKADPGRGDNFFDLGGHSLLAPQIVSRIAAELGVAVPMTAIFATADLAGLAAVVDGRPAEAVDLRAEAVLPGDVAFTGAPIPDGPPRRVLLTGATGFLGAYLLAELLRATDAEIHCLVRGDAPDGRLRGGLERYGLWDDRFAGRIIPEAGDLDLPGLGLPASRSAELADSVDLIVHNGALVNFALPYRRLRAANVDGVLEILRLAARGRITTPVHLVSTLGVHLTPGERTVRETDPLPDPGPLHLGYDQSKWVADRLAGAARRTGLPIAIHRPARVSADSRTGRSVDGDFLGRLFATCARLGAVPDGERLDMAPVDHVAAAIAHLAVSRAGGDFHYYNPRVLSSAELAGGLRERGFPARLVPGGEWRRLVRDRLAVGDDLPIALYPGFFADHEGAAGPSFDCSATEEALAGAGLVCPPADGDLLGRYLDHYVSTGVLAGGRRA
>NC_013595.1|WP_012888915.1|2351289_2352777_+|MFS-transporter
MVAVHDGIRRFVVIWAAQLLSIIGSSLTGFVLGVWVYQKNGSATEFVLIMLCAVLPEVLLSPLAGAVADRWDRRRLLMAADAGAAVVTGVLAVLLATGTLQVWHVYVVTVAGAVFGTFHMAAYHSMMPLIMPQRHLGRANGLMQVADSVKIAAPLLAGTLLVTVGVTGVVVVDLATFLVTRVVMFAVRLPPEVTRPGGVPTAPEPLRRDLLFGWRHLRARPGLFQLVVVLAAYNLFFGMSGVLVQPLILSFGSAAVLGALMFAGGAGVFAGGLVLSAWGGPRHRVRGIAVFVALGGVLLALHSVAPSPWLIAVVAPAFLFTLPFVQGTGMTVLQLKTDPAALGRVLSTVRTVTQAATVLTYLAAGPLADHVFEPMMAPDGALADTIGGVIGTGPGRGLAAIFLLTGLGLLLLAPLAYLWPRLRNVESELPDAEDVHPPEPAPAETTPARSPPDDDATRPPVRDGDASPEAGTEHPDVAQGVQVAQGDSDAALSRP
>NC_013595.1|WP_012888916.1|2352754_2353990_+|methyltransferase-domain-containing-protein
MPLYLDPEQLREQAPGPHLDLIGTMAFRAAGAAQRLGVFDALLDGPLPVTELAARTGTDEGTLPVLLDALVSFGYLDRAPGQVYANSPMTAGSLDRRSPWSYAPALAFWHDLLGELWDGLEESVRTGRPGADFYGWLESRPRTLREFQTMLDGMATGLAPLVAATAPDPGRRLLDVGGGHARYSIALCEAHPELTATIVDLPKALEGGRARVEQAGLAGRVRTVAGDVTEADLGSGHDTALLFNLCHGFDGPDNRALLKRVAAALRPGGTVLVLESFADLPEGTPLVAEAFTRAFSLNLAVTQGGRIYAFDEIAGWLTEAGFGRIERRALDGPSELLIARLPGADTAGPSGTDTARVPETDRPRSAGADAVQLPGADTARAPEPDGGHAHTLAGGAPRAVLPVAWTREEIR
>NC_013595.1|WP_012888917.1|2353986_2355309_+|FAD-dependent-monooxygenase
MTRRIIIVGAGPAGTLLACYLARRGFRVDVYERRPDPRLLDEEESRSINLGLSARGIKALDDIGLMDTLWPLTVPMRGRAIHLPGGGAPFQPYGAHEGEILHSVLRRDLITTLIDHAEAQPGVSFHFRHRLVDLDREAAAVHLAEEGTGAALTVRGDAVIGADGAFSQVRARMQHGLRVDHHQEFLEWGYKELTIPAADDGSARTRLEALHVWPGEDALIVAHPNRDNSLTGTLFLPVERFEEITDPEEFFRTRFPDAIGLMPHLAKEYAEHPVGHLVSIRTSPWHYRDRVALIGDACHAVYPFYGQGMNSSLEDCTVLDRCLDAHPDDLGRAFAEYQRLRKPHTDVLDELSKQNFVELRDRLRSPFHLARKKADLLLARLLPGRWVPLYTMISHTTTPYADALARARRQDTILRWTGVAMGAVALAAVRRSTRKGGPRC
>NC_013595.1|WP_012888918.1|2355302_2355983_+|hypothetical-protein
MLTDPADPSRVLIETADLDGDHDLVRRYGVPLKEIVVWAREYLCRPHADLGRNGPVCPYAQTSLDRGTFYLAVRPGTPDGAEAAEVLDGYRDWFLRLVSPPGVSAQYRTILVLFPDLPEAAAAEVIDVAQDALKSRYVSEGLMIGEFYPGPPPKAGLWNPGFRPLGSPVPLLAIRHMVATDFPFLRDDPGQFAAYLERFGHRPPAALREEVQAVARHYGLMTEPAT
>NC_013595.1|WP_012888919.1|2356050_2357505_-|glycoside-hydrolase
MSEFIADPSDRGLRRLAAGTLLVAFRGTTAPEWVLRDLENGLGGVTLFGFNVADPAQLSGLTARLREAGEPVISLDEEGGDVTRLDYHVGSPYPGNAALGAVDDVELTRRVYRSIGDDLARCGVNLDMAPSADVNTADDNPVIGTRSFGPDTALVARHTVAAVHGLQAAGVAACVKHFPGHGATRQDSHLEIPLVDASLELLRERELVPFRAAIDAGTRSIMTAHVRVPALTGTTPATLSAAALTVLLRGELGYDGVIVSDALDMKAVTDTYGLAGGSVLSLAAGTDLLCLGPLPTEDDVRRIITEIVAAVGDGRLPLARLEAAAERVARLRAWFGTSQTGQAEKNVIGLAAARRAVSLTGSASPLVDPLVVEVDTPPTIAVGDVPWGFAPLLPQAEVVRVKPETADVPGILERATGRSLVVVVKDAHRYEASKSVVSALLAARPDATVVEMGLPIWRPEGVTYLATYGAARANAQAAAELLGV

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Crispr_ID: NC_013595_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_18

2457239-2457344

Orphan

Consensus_repeat	Method
CGGGGTGGAAGGTCAAAAGCGCAGCGAGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_18

>merge|NC_013595|18|2457239-2457344|CRISPRCasFinder
CGGGGTGGAAGGTCAAAAGCGCAGCGAGGGGTGGGTGGCGTGGCCCGGGGGCCGGCCCATCCGCGCGGCGCCGTACGGGGTAGAAGGTCAAAAGCGCAGCGAGGGG

>NC_013595|18|18|2457239-2457344|CRISPRCasFinder
CGGGGTGGAAGGTCAAAAGCGCAGCGAGGGG	TGGGTGGCGTGGCCCGGGGGCCGGCCCATCCGCGCGGCGCCGTA
CGGGGTAGAAGGTCAAAAGCGCAGCGAGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012889001.1\|2460416_2462813_+\|ComEC/Rec2-family-competence-protein	unknown	unknown	gnl\|CDD\|225212
NC_013595.1\|WP_012889004.1\|2464142_2465126_+\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|236130
NC_013595.1\|WP_012889000.1\|2458232_2459012_+\|ComEA-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|224472
NC_013595.1\|WP_043651785.1\|2446162_2447620_+\|GTPase-HflX	unknown	unknown	gnl\|CDD\|274455
NC_013595.1\|WP_012889007.1\|2467039_2467312_-\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|376586
NC_013595.1\|WP_012888993.1\|2451225_2452239_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|340411
NC_013595.1\|WP_012888994.1\|2452226_2452628_-\|anti-sigma-regulatory-factor	unknown	unknown	gnl\|CDD\|340411
NC_013595.1\|WP_012889009.1\|2468536_2470375_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NC_013595.1\|WP_012888998.1\|2454854_2456063_+\|imidazolonepropionase	unknown	unknown	gnl\|CDD\|238621
NC_013595.1\|WP_043651789.1\|2447952_2449548_-\|fused-response-regulator/phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_013595.1\|WP_012889005.1\|2465394_2466300_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NC_013595.1\|WP_012889008.1\|2467460_2468462_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119353
NC_013595.1\|WP_012889006.1\|2466373_2466862_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_013595.1\|WP_012888999.1\|2456183_2457032_+\|DegV-family-protein	unknown	unknown	gnl\|CDD\|273257
NC_013595.1\|WP_012889003.1\|2463888_2464041_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_148269521.1\|2463218_2463677_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	unknown
NC_013595.1\|WP_043655264.1\|2452624_2453008_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132912
NC_013595.1\|WP_012888989.1\|2445339_2446035_+\|DUF4097-family-beta-strand-repeat-protein	unknown	unknown	gnl\|CDD\|226123
NC_013595.1\|WP_148269520.1\|2449540_2451217_-\|response-regulator	unknown	unknown	gnl\|CDD\|274362
NC_013595.1\|WP_012888996.1\|2453004_2453880_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132912

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012889001.1\|2460416_2462813_+\|ComEC/Rec2-family-competence-protein	gnl\|CDD\|225212	COG2333, ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only].	5.83693e-48
NC_013595.1\|WP_012889004.1\|2464142_2465126_+\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|236130	PRK07914, PRK07914, hypothetical protein; Reviewed.	2.42626e-92
NC_013595.1\|WP_012889000.1\|2458232_2459012_+\|ComEA-family-DNA-binding-protein	gnl\|CDD\|224472	COG1555, ComEA, DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair].	1.47453e-25
NC_013595.1\|WP_043651785.1\|2446162_2447620_+\|GTPase-HflX	gnl\|CDD\|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	6.36716e-168
NC_013595.1\|WP_012889007.1\|2467039_2467312_-\|30S-ribosomal-protein-S20	gnl\|CDD\|376586	pfam01649, Ribosomal_S20p, Ribosomal protein S20. Bacterial ribosomal protein S20 interacts with 16S rRNA.	1.1598e-24
NC_013595.1\|WP_012888993.1\|2451225_2452239_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|340411	cd16934, HATPase_RsbT-like, Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains. This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.	2.1605e-27
NC_013595.1\|WP_012888994.1\|2452226_2452628_-\|anti-sigma-regulatory-factor	gnl\|CDD\|340411	cd16934, HATPase_RsbT-like, Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains. This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.	1.01841e-43
NC_013595.1\|WP_012889009.1\|2468536_2470375_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_013595.1\|WP_012888998.1\|2454854_2456063_+\|imidazolonepropionase	gnl\|CDD\|238621	cd01296, Imidazolone-5PH, Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria, the enzyme is part of histidine utilization (hut) operon.	1.35699e-140
NC_013595.1\|WP_043651789.1\|2447952_2449548_-\|fused-response-regulator/phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.34477e-33
NC_013595.1\|WP_012889005.1\|2465394_2466300_-\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	3.455e-43
NC_013595.1\|WP_012889008.1\|2467460_2468462_-\|hypothetical-protein	gnl\|CDD\|119353	cd02874, GH18_CFLE_spore_hydrolase, Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the forespore inner membrane and is deposited as a mature enzyme in the cortex layer of the spore. As part of a sensory mechanism capable of initiating germination, CFLE degrades a spore-specific peptidoglycan constituent called muramic-acid delta-lactam that comprises the outer cortex. CFLE has a C-terminal glycosyl hydrolase family 18 (GH18) catalytic domain as well as two N-terminal LysM peptidoglycan-binding domains. In addition to SleB, this family includes YaaH, YdhD, and YvbX from Bacillus subtilis.	0.00173922
NC_013595.1\|WP_012889006.1\|2466373_2466862_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	8.17784e-16
NC_013595.1\|WP_012888999.1\|2456183_2457032_+\|DegV-family-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	1.0358e-92
NC_013595.1\|WP_043655264.1\|2452624_2453008_-\|STAS-domain-containing-protein	gnl\|CDD\|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	1.08252e-29
NC_013595.1\|WP_012888989.1\|2445339_2446035_+\|DUF4097-family-beta-strand-repeat-protein	gnl\|CDD\|226123	COG3595, COG3595, Uncharacterized conserved protein [Function unknown].	1.02841e-05
NC_013595.1\|WP_148269520.1\|2449540_2451217_-\|response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	9.81547e-53
NC_013595.1\|WP_012888996.1\|2453004_2453880_-\|STAS-domain-containing-protein	gnl\|CDD\|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	1.44094e-43

>NC_013595.1|WP_012888999.1|2456183_2457032_+|DegV-family-protein
MSPSVAVVTDSTAYLPREETSRLGIATVPLQVVVGGRPLDDVAQIDSATMNDALREWAPVTTSRPAPQRFADIYDEAAARGAVAVVSIHLSGEMSGTVEAARAGAEDALIPVEVVDSRSIAMGLGFPVLAAAEAAARGATMTEAADAARRCMDSTRSFFYVDTLEYLRRGGRIGAAATLLGSALMIKPLLHITGGVIVPLEKVRTAARAIARLEDLAVQAAGTGPVNVAVQHLAASSRAESLAARLPQRIPGLVKVTVVEVGAVIGAHAGPGMLGLTVAPAS
>NC_013595.1|WP_012888998.1|2454854_2456063_+|imidazolonepropionase
MTVRLLTNIGRLWTGNDVCSNAAILVHNDRIAWVGRAADLPQSVPGVVDDIVDVDHVENLGGALVTPGLIDAHTHPVYAGNRYAEMAMRSGGSTPSAITAAGGGIGSTVTVTRGTDPWTLCNGVRERLREWLLSGTTTVEAKTGYHLTRDGELADVRLLRELEKEPMMPRVHVTFMAAHVVPPEYFGRQRDYVEAVGAWCADAAAAGADSVDVYCDEGHFTTEEARWVLASGRNVGLLPRVHAGAYSRRGAVQLAAELGCASADLLHHTSDEDISILARYGVPAVVCPGTALQRGSLPPVRRMLAQGVTVALGSDHNPGHCGITSMSLVISLAVAAFGMSVGDALRAATLGGATVLGVPDRGVLAPGRLADIVQWDADHEGAFAWAFGLKPRRVWRGGNPVQ
>NC_013595.1|WP_012888996.1|2453004_2453880_-|STAS-domain-containing-protein
MGVTLSVHADAGRRRIEELLQENEEPVFKRWLEIAGSSSNGHVDRSSLVGQLRELYQALHRSLSGSSDFSDLRGLLAELSRSRARQGFTPTETAIVVFGLKEALYEIIENDGSPEALRGFIWFSQVIDELGLFTMESYASAREKVIIDQAEQLLELSTPVVKLWEGIVAVPLVGTLDSARTQVVMEKLLQTLVDTGSEHAVIDITGVPAVDTQVAQHLLKTVVAARLMGAECVISGIRPQIAHTIVTLGIEFGDIVTKASLADALAHALRQSGVEFVKRRGNRIAVRTVED
>NC_013595.1|WP_043655264.1|2452624_2453008_-|STAS-domain-containing-protein
MMDRVPVLKLGDILIVSIQIDLQDQSVLALQEDLADQVVATGARGVIIDITAVEIVDSFIGRMLATIAAISRMLDAETVVVGMRPAVAITLVELGLSLGGVRTALNLEKGVALLNHLEGAQIVTAAR
>NC_013595.1|WP_012888994.1|2452226_2452628_-|anti-sigma-regulatory-factor
MTTSDELPIKSNSDVVLVRQHVRTAAVNVGLSLVDQTKVVTAASELARNALVYAGGGQVRIEIVNNGIRKGLRLAFSDTGPGIPDIPQALTDGWTTGGGLGLGLSGSRRLVDEFDLQSAPGEGTLITVTKWAR
>NC_013595.1|WP_012888993.1|2451225_2452239_-|SpoIIE-family-protein-phosphatase
MGKVIRSQNDTWTRAEDASAIGALRRSAVMLAEARGFDEEDAGRVAVAVSEAASNLVKHAVEGVMLIRPHPELDSAVEVIAIDRGPGMRDVSRALRDGYSTAGTLGIGLGGIARMASGYEVHSMPGRGTVLGMYFTARGAPRPASRVSGMTRPIGEEVVCGDAFAVAENDATTTVMLCDGLGHGSLAAHASHEAVRLFLQHADLAPVTVLERIHLGLGSTRGGAVAVARIDRAAGTVNFAGLGNVSAWIAHQEGRQGMISVPGIAGHKARTLRQYEYAVPQHSMIVFHSDGLSDRWDITTYPGLVARPPSVVAATLLRDAGTRRDDACVVAMRPWTS
>NC_013595.1|WP_148269520.1|2449540_2451217_-|response-regulator
MAGDELIRIRVVDDQDVFAMRKLGREVAEASGLDTQDQIRVATALSEIGREVLSEGAAASAAFLLGHDNLIVTIDLSAMADLRPTDGVTLAGRLVDAIELDPAVGRITMLKRLPAGRPRPSAEEIRARLAKLTPATALDELRQQNRELAATLEEVLQLNTELQETNQGVLALYNQLSEELEETNRGVVALYAELDGKSAQLREASDAKNRFWATVSHELRTPLNSIIGLVRLLVGPGGDPLVEEQLHQIQLIGSSAETLLSLVSELLDMAKAEAGRLAPQPSVVDLVALAERMRMTLRPTSGTDQVTLSVKVSDGAAELFVDEVMLTRILRNLLSNGLKFTEEGEVRLEIDLDAGTHEMVFTVTDTGIGVPEEHLERVFEEFFQVPGPIQARTKGTGLGLPYARRLAQAMGGSLQLSSSPEGTMAVLRLPHRYDGTPVIGRVLVADDDEEFRATVRRMLTGFAAHIDEAPDGLVALEVMTANPPDLALVDLLMPRLDGAALMQRMADDPRLREVPVLVVTVATSSQYPQAADTVISKHGLRRESLLEAIRNALGHRDE
>NC_013595.1|WP_043651789.1|2447952_2449548_-|fused-response-regulator/phosphatase
MSEGPAMVLVVDDTPTKLYILSSWLRRSGHEVVQATGGLEALAKVRELRPDLVVLDVRLPDISGYEVCEQIKADKATSSIPVIQISGAAITPADRAQGLERGADAYLAEPVEPDEFAATVEATLRYYRARQRAERMAERLAALTQVSLAMNSSDTFEGLLTTAVEGAARILGRHAGVLALPPDGRTRRFDALPSESVAVARSAAPDTLLRLSAMSLGNTAGTEVFTIPRGDWTKLMPDAEPLGDVSAMICRTKLGRPPVYLGVDAVPPLDADEFNVLRQLGQALALSVDALRAYAEEHAIALTLQRSLLPARIPETPGLSISWRYQPAVDNIEVGGDFYEVLRLGDQVLIAIGDVQGHSLLAATVMAELRHALRASLIGTVDLGASMALLNNVLRRYHPGMTATVCLILIAPETGEMEVANAGHIPPLIVGDGEVRYHDLGNLLLGVAEETYRVDRLALPEGGSVLMFTDGLVEDRDKLLDESLEIVRQLAEVVEDDLELFCDRLIKQFGAREDDVALVAFRREAPGTGSA
>NC_013595.1|WP_043651785.1|2446162_2447620_+|GTPase-HflX
MNHAPEWSNDIDTREPLDIDQFDDLPGIGEMDLAERQALRRVAGLSTELEDVTEVEYRQLRLERVVLVGVWTSGTAIDAENSLLELKLLAETAGSEVLEGVIQRRQKPDTATYIGSGKAQELADIVSATGADTVVCDGELSPGQLRQLEEVVKVKVIDRTMLILDIFAQHAKSREGKAQVELAQLNYLLPRLRGWGGNLSRQVGGRAAGGVGMGGRGPGETKIELDRRRIRERMAKLRRQIIEMTTSRVTKRARRQEREVPAVAIAGYTNAGKSSLLNRLTGAGVLVEDSLFATLDPTVRRAHTPEGRLFTLADTVGFVRHLPHQLVEAFRSTLEEVGDADLILHVVDGSHPDPESQLAAVREVVADIEGARDIPEIVVINKADVADPVVLAQLTAREKHTVVVSARTGAGIDELLAIIERELPRFDQEVRLLVPYQRGDLISRAHKEGEVLGVEHTEDGTILHARVLPALFAELEKTAKPVETV
>NC_013595.1|WP_012888989.1|2445339_2446035_+|DUF4097-family-beta-strand-repeat-protein
MKKNVIVAGALLGSVLVLSGCRVDFGLGDRQQEVASYDVADKLTVLDVRAGAGDIVVTESGRSGVRVTETLHWRGDKGDKPVTEHAVEGDTLVLRDKCPHGNCSVDYRIEIPKGLTTKLDAGSGTLTLRALTGEVTADTGSGNIEAGTLGTKRFVAETGSGDVEVKFAAVPDKVDVRTGSGDATVRLPQGAYDVTAETGSGNKTVQVTDDPSAPRSVLVRTGSGDAKVLRP
>NC_013595.1|WP_012889000.1|2458232_2459012_+|ComEA-family-DNA-binding-protein
MDGPVNPDDSARFDGPAARMRSTPVPPSFEALRTAVAAQAPLLAPGRPGLRLLLLIALIAVVTGGVHAWRSQPEPEPLPPPVSGSSPLTPASPLSSQSGSPQPGSARFGSAQSGPSRAGPLIEVTVHVTGKVRRPGVITLPTGSRITDAVQAAGGVRKGAATGPLNLARKLVDGEQIVVGAPAPAAAAPLMADPAPVVLDLNTATPEQLEQLPGVGEVLARRIVEYRDGHGGFRTVEQLREVSGIGDRKYAEIREKVHV
>NC_013595.1|WP_012889001.1|2460416_2462813_+|ComEC/Rec2-family-competence-protein
MSRFGAASALRDDGATERGLSAYALHLVLPALVAWTTALILLGCPSWTGALVAALAAAGALSAAVLVPAGGIAGWRNVVIAVLGCAAAVAGTVAFRLHAVSAGPVAELVEKRASTVMEAVVTGDPREPAQRGGPFRRDSFVVPARIEAIGTGPGRVTLQAPVVMLASGGEWRTLLPSQRIAVQGRFGPADSGELLAAVVLVRGPPRVLDGPSWAQRTAGALRSGLREAADVLPPLQRGLLPGLVVGDVSRMDGQVRADFKEAGLSHLTAVSGANLAIMAGAAVAVGRTAGLPLAARAALAVFAMLAFALVARPSPSVLRALLMGTVAAVALGTGRSRDGVTALSATVLGLILFDPALARSYGFALSVCATGGILVLAPRWRDRLATRMPRWAAEAIAVPAAAQAAVTPVLVLMSGQLAPVAIPANLLAGPAVAPATLLGSVAALVAPLHMGLARLLIHPAGLAAGWIIEVAEHAAGTPLAVIPWPGGVAGLIALAVAVPVAILVLRRRWSRRIALAVAAGAIVAVTMAEPIVARWPPRDWLLVACDVGQGDALLVAAGPGRAVVVDAGPDPVLMDRCLRSMGIREVPLVILTHPHFDHVGGLEGIFRGRGVGAVVVTPHGGAERENVRLSGDLARRRVVEWAARPGASWRFGPSELTIIAPRAETPPEGRGEGAVVNNASVVVHVRWAAGTALLSGDIETEAQSELLRRGFPPADILKVPHHGSAGHDPGFFAATGARAALISVGADNDYGHPAPSTLARLNRLGVRVYRTDLSGALAVVARAGGLAVIPRGRSGRGG
>NC_013595.1|WP_148269521.1|2463218_2463677_+|nuclear-transport-factor-2-family-protein
MQGSPFSSGAFTPTAEDLQSVEAWFAEYDAHSAKVDVERMADMAMFPLNVVTDSADGEGLAAQWTRERFTRTMAEVMGGGEPGDIAMESTRTPHFLTKHLVVVVTDATMTVNGESYGMRYADLLVKAGGRWVFQTMVQGGWAEAWKETSQGA
>NC_013595.1|WP_012889003.1|2463888_2464041_-|hypothetical-protein
MNSTTCRHACPRCGTTLDEGPIMYRCARCSRSVYAADVDTEFRRPLKAAV
>NC_013595.1|WP_012889004.1|2464142_2465126_+|DNA-polymerase-III-subunit-delta
MLLDMAATDPAPVILILGDEELLADRAVGEVIAAARATDPATEVYDLIGGKVEPGELTRLSSPSLFGDRSVVAIRSAQDLSKEVVSEIVSYAAHPAEDTALVLVHPGGVKGKALVDGVKKAGAHVVAVTKLTKPAERLAFVKAELKRAGRSIGADAAAALLDAVGNDLRELAAACSQLAFDTPGKTIDEAAVARYHRGRAEVSGFTVADSAVEGRLGDALEQLRWALATGTAPVLLVSALAGGLRSLAKVGGAPRNLRGGQLASHLGMPPWKIDRVQRQLNGWGPDGIARALQAAATADEQVKGGGADPAYALEHMIQTVVASRTGR
>NC_013595.1|WP_012889005.1|2465394_2466300_-|EamA-family-transporter
MPAPRLALVAATALAPTVWGTTYIVTTELLPPDRPLLTALLRALPAGLLLLAMTRTLPRGNWWWRAPVLGALNIGLFFPLLFLSAYRLPGGVAGVLGAIQPLLVAGFTRAVLRETVPVHRVIAGITATVGVSLVVLRANAALDAVGVAAGVVAAAGMAAGVVLTRSWGKPPGVSDLALTGWQLTAGGLMIAPVALAAEGMPPALDGAAVGGYLWLGLVGTAAAYTLWFRGIARLPAAQVSLLGTLSPLTAALLGWIALGQSLSPLQLTGFALALGATVLGQFPAPRRTRVAADPQPAPSRP
>NC_013595.1|WP_012889006.1|2466373_2466862_+|MarR-family-transcriptional-regulator
MTEDPVDRIVLQWRRERPDLDPSPMGIFGRIYRIARLMGDRMEEVHGAHGLGRGEFDVLATLRRAGEPYTLSPKAITATLMLTSGGMTGRLDRLERAALIVRAPDPDDRRALRVSLTAQGLQVIDEAVAAGLGPQHEALAALPEEDRERLGALLRTLLGELE
>NC_013595.1|WP_012889007.1|2467039_2467312_-|30S-ribosomal-protein-S20
MANIKSQIKRNRQNEKARLRNKAVKSSLKTAVRKFREAADQGNVDEAVVLQRAACRQLDKAASKGVIHKNQAANRKSAIAQRVVELSAAK
>NC_013595.1|WP_012889008.1|2467460_2468462_-|hypothetical-protein
MIARTRARRGLRFLVMVAAVLLVLPGVAAATLTLQFTGTPAPWAKSTGHDALWLGHAWVDGRRSAADLKELAARLRKTGIRDVYVHSGPFEYDGTLPAAKHPAAKDFLERWRAELPKVRVSAWLGQKVDGGLDLDDPATRQRVLDSAGGVMALGFDGVHYNFEPVGSGDAEFLDLLTRTRPIVGDGLLSTSTPQIEPFPLTRPAVRAVIGHDKYWSPEYFREVAARTDQVAIMTYDSALPSELLYGGHVVRQGGLALELVPPEKTVLIGAPAYHDHDLPWVDAAESVATAAEGARLALTAYGKPRERFGLALYVDFAATAEDWAEYGRFWSRP
>NC_013595.1|WP_012889009.1|2468536_2470375_+|elongation-factor-4
MRIQPGQTDPAVIRNFCIIAHIDHGKSTLADRMLQITGVVDDRSMRAQYLDRMDIERERGITIKSQAVRLPWQMGDTDYVLNMIDTPGHVDFTYEVSRSLQACEGAILLVDAAQGIEAQTLANLYLAMNNDMTIIPVLNKIDLPAAQPEKYAAEIAHLIGCEPEDVLKVSGKTGVGVRELLDHVVQNVPAPVGDADAPARALIFDSVYDTYRGVITYVRVMDGHLGKRERILMMSTTAAHETLEIGVISPEPKIADKGLGVGEVGYLITGVKDVRQSRVGDTVTSVVRPAAKALSGYEHPKPMVFSGLYPIDGDDYPELREALDKLQLNDAALVYEPETSAALGFGFRCGFLGLLHMEIVRERLEREFNLSLISTAPNVVYQVIMEDGKEVTVTNPSEFPTGKVEKVFEPMVKSTVLVPSEFIGAIMELCQNRRGNLQGMDYLSEDRVEIRYTMPLGEIIFDFFDQLKSRTRGYASLDYEPSGEQESELVKVDILLQGEAVDAFSAIVHKDKAYAYGVEMAKKLRELIPRQQFEVPIQAAIGARVIARENIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGRVEVPQEAFVAALSTESSADKTKK

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Crispr_ID: NC_013595_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_19

2473873-2474063

Orphan

Consensus_repeat	Method
GGCTGGGTGTAACCGGGCTGGGGTGG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_013595_19

>merge|NC_013595|19|2473873-2474063|CRISPRCasFinder
GGCTGGGTGTAACCGGGCTGGGGTGGTGGAATGTGGCCGGGCTGGGGGTAACCGGGCTGAGGTGGCTGGGTGTAACCGGGCTGGGTGTGGCCGCTCTGGGGCGGGGCGTAGCCGGGCTGGGTGTGGCCGCTCTGGGGTGGCGGGTAGACCTGGCCGGTCTGGGGCGGTGGGGTGTGGCCGGGCTGGGACGG

>NC_013595|19|19|2473873-2474063|CRISPRCasFinder
GGCTGGGTGTAACCGGGCTGGGGTGG	TGGAATGTGGCCGGGCTGGGGGTAACCGGGCTGAGGT
GGCTGGGTGTAACCGGGCTGGGTGTG	GCCGCTCTGGGGCGGGGCGTAGCCG
GGCTGGGTGTGGCCGCTCTGGGGTGG	CGGGTAGACCTGGCCGGTCTGGGGC
GGTGGGGTGTGGCCGGGCTGGGACGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_148269522.1\|2475026_2475590_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012889015.1\|2475947_2476961_+\|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
NC_013595.1\|WP_012889004.1\|2464142_2465126_+\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|236130
NC_013595.1\|WP_012889021.1\|2480766_2481831_+\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224616
NC_013595.1\|WP_012889007.1\|2467039_2467312_-\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|376586
NC_013595.1\|WP_012889008.1\|2467460_2468462_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119353
NC_013595.1\|WP_043655278.1\|2479559_2480039_-\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NC_013595.1\|WP_148269521.1\|2463218_2463677_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	unknown
NC_013595.1\|WP_043655280.1\|2480324_2480675_+\|histidine-triad-nucleotide-binding-protein	unknown	unknown	gnl\|CDD\|238607
NC_013595.1\|WP_012889017.1\|2478158_2478890_+\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl\|CDD\|236959
NC_013595.1\|WP_012889009.1\|2468536_2470375_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NC_013595.1\|WP_012889005.1\|2465394_2466300_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NC_013595.1\|WP_012889016.1\|2476973_2478116_+\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|237654
NC_013595.1\|WP_012889010.1\|2470490_2471768_-\|glycoside-hydrolase-family-18-protein	unknown	unknown	gnl\|CDD\|119365
NC_013595.1\|WP_012889006.1\|2466373_2466862_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_013595.1\|WP_012889022.1\|2481874_2482357_+\|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl\|CDD\|234575
NC_013595.1\|WP_012889003.1\|2463888_2464041_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012889011.1\|2472118_2473330_+\|coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|180172
NC_013595.1\|WP_012889013.1\|2474128_2474971_-\|DUF3097-domain-containing-protein	unknown	unknown	gnl\|CDD\|378628
NC_013595.1\|WP_012889018.1\|2478894_2479563_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273167

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012889022.1\|2481874_2482357_+\|rRNA-maturation-RNase-YbeY	gnl\|CDD\|234575	PRK00016, PRK00016, metal-binding heat shock protein; Provisional.	3.90847e-68
NC_013595.1\|WP_012889015.1\|2475947_2476961_+\|heat-inducible-transcriptional-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	2.51592e-156
NC_013595.1\|WP_012889004.1\|2464142_2465126_+\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|236130	PRK07914, PRK07914, hypothetical protein; Reviewed.	2.42626e-92
NC_013595.1\|WP_012889021.1\|2480766_2481831_+\|PhoH-family-protein	gnl\|CDD\|224616	COG1702, PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms].	2.58777e-143
NC_013595.1\|WP_012889007.1\|2467039_2467312_-\|30S-ribosomal-protein-S20	gnl\|CDD\|376586	pfam01649, Ribosomal_S20p, Ribosomal protein S20. Bacterial ribosomal protein S20 interacts with 16S rRNA.	1.1598e-24
NC_013595.1\|WP_012889008.1\|2467460_2468462_-\|hypothetical-protein	gnl\|CDD\|119353	cd02874, GH18_CFLE_spore_hydrolase, Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the forespore inner membrane and is deposited as a mature enzyme in the cortex layer of the spore. As part of a sensory mechanism capable of initiating germination, CFLE degrades a spore-specific peptidoglycan constituent called muramic-acid delta-lactam that comprises the outer cortex. CFLE has a C-terminal glycosyl hydrolase family 18 (GH18) catalytic domain as well as two N-terminal LysM peptidoglycan-binding domains. In addition to SleB, this family includes YaaH, YdhD, and YvbX from Bacillus subtilis.	0.00173922
NC_013595.1\|WP_043655278.1\|2479559_2480039_-\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	3.97511e-47
NC_013595.1\|WP_043655280.1\|2480324_2480675_+\|histidine-triad-nucleotide-binding-protein	gnl\|CDD\|238607	cd01276, PKCI_related, Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members.	3.32464e-52
NC_013595.1\|WP_012889017.1\|2478158_2478890_+\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl\|CDD\|236959	PRK11713, PRK11713, 16S ribosomal RNA methyltransferase RsmE; Provisional.	1.32107e-73
NC_013595.1\|WP_012889009.1\|2468536_2470375_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_013595.1\|WP_012889005.1\|2465394_2466300_-\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	3.455e-43
NC_013595.1\|WP_012889016.1\|2476973_2478116_+\|molecular-chaperone-DnaJ	gnl\|CDD\|237654	PRK14278, PRK14278, chaperone protein DnaJ; Provisional.	0
NC_013595.1\|WP_012889010.1\|2470490_2471768_-\|glycoside-hydrolase-family-18-protein	gnl\|CDD\|119365	cd06548, GH18_chitinase, The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.	4.39763e-120
NC_013595.1\|WP_012889006.1\|2466373_2466862_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	8.17784e-16
NC_013595.1\|WP_012889011.1\|2472118_2473330_+\|coproporphyrinogen-III-oxidase	gnl\|CDD\|180172	PRK05628, PRK05628, coproporphyrinogen III oxidase; Validated.	0
NC_013595.1\|WP_012889013.1\|2474128_2474971_-\|DUF3097-domain-containing-protein	gnl\|CDD\|378628	pfam11296, DUF3097, Protein of unknown function (DUF3097). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.11991e-162
NC_013595.1\|WP_012889018.1\|2478894_2479563_-\|hypothetical-protein	gnl\|CDD\|273167	TIGR00601, UV_excision_repair_protein_RAD23_homolog_A, UV excision repair protein Rad23. All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	0.00232589

>NC_013595.1|WP_012889011.1|2472118_2473330_+|coproporphyrinogen-III-oxidase
MPSTLPDGDPVPASGRLPDSALHGLGGRPFGFYVHVPFCVTRCGYCDFNTYTASELGPGASHKDYADTAIDEVRRARANLGGADLPVETVFFGGGTPTLLPAGDLVRILGAIEEEFGLAPGAEVTTEANPESVDPAYLSELRGGGFTRMSFGMQSAREHVLEVLERRHTPGRPAHAVREAREAGFDHVNLDLIYSTPGESDDDWRASLAAAIEAGPDHVSAYSLIVEDGTRLAARIRRGELPMPDDDVAADRYLIADAMLAEAGFEWYEVSNWATSEAGRCRHNLLYWTGGDWWGVGPGAHSHVGGTRWWNVKHPAAYARRLASGVSPAHAREVLTAEDRAVERLMLELRLVQGFPLKEIERPPVVARALADGLLEMEPFKAGRAVLTLRGRLLADALVRDLT
>NC_013595.1|WP_012889010.1|2470490_2471768_-|glycoside-hydrolase-family-18-protein
MQRLLRNTLAAALAAGLTALAAPAPAQAQAHPDHGDRFKRVAYFVQWGIYGRNYHVKDIDTTGAAAKLTHINYAFGFVSAGGDCVSSDAWADWQRPVPADQSVDGVADAEGQALNGNLNQLKKLKAKHPGLKAMISLGGWSGSKYFSDAVLTAEGRTKLAASCVDLWLKGNLPGAAPGTGAGVFDGIDLDWEWPGSSGADGNVIRPEDKRNFTLFTAELRRQMNEFDRKSELSAYLPAAAAKIDSGFEVRELFRHFTFATVQGYDLRGSWETVTGHNGNLFADRRDPNTVKYSVDQTVRDYLSRGAPARKIVVGVPAYGQGWTGVTGGGNGLFKNATGPAQGTWAAGVDDYENIVKKPGKRYRDLRTGAAWIYDGNEFWSYDDPTTVAQKAAYIRLKGLGGSMMWSIDQDDSKSSLTSALYSVLR
>NC_013595.1|WP_012889009.1|2468536_2470375_+|elongation-factor-4
MRIQPGQTDPAVIRNFCIIAHIDHGKSTLADRMLQITGVVDDRSMRAQYLDRMDIERERGITIKSQAVRLPWQMGDTDYVLNMIDTPGHVDFTYEVSRSLQACEGAILLVDAAQGIEAQTLANLYLAMNNDMTIIPVLNKIDLPAAQPEKYAAEIAHLIGCEPEDVLKVSGKTGVGVRELLDHVVQNVPAPVGDADAPARALIFDSVYDTYRGVITYVRVMDGHLGKRERILMMSTTAAHETLEIGVISPEPKIADKGLGVGEVGYLITGVKDVRQSRVGDTVTSVVRPAAKALSGYEHPKPMVFSGLYPIDGDDYPELREALDKLQLNDAALVYEPETSAALGFGFRCGFLGLLHMEIVRERLEREFNLSLISTAPNVVYQVIMEDGKEVTVTNPSEFPTGKVEKVFEPMVKSTVLVPSEFIGAIMELCQNRRGNLQGMDYLSEDRVEIRYTMPLGEIIFDFFDQLKSRTRGYASLDYEPSGEQESELVKVDILLQGEAVDAFSAIVHKDKAYAYGVEMAKKLRELIPRQQFEVPIQAAIGARVIARENIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGRVEVPQEAFVAALSTESSADKTKK
>NC_013595.1|WP_012889008.1|2467460_2468462_-|hypothetical-protein
MIARTRARRGLRFLVMVAAVLLVLPGVAAATLTLQFTGTPAPWAKSTGHDALWLGHAWVDGRRSAADLKELAARLRKTGIRDVYVHSGPFEYDGTLPAAKHPAAKDFLERWRAELPKVRVSAWLGQKVDGGLDLDDPATRQRVLDSAGGVMALGFDGVHYNFEPVGSGDAEFLDLLTRTRPIVGDGLLSTSTPQIEPFPLTRPAVRAVIGHDKYWSPEYFREVAARTDQVAIMTYDSALPSELLYGGHVVRQGGLALELVPPEKTVLIGAPAYHDHDLPWVDAAESVATAAEGARLALTAYGKPRERFGLALYVDFAATAEDWAEYGRFWSRP
>NC_013595.1|WP_012889007.1|2467039_2467312_-|30S-ribosomal-protein-S20
MANIKSQIKRNRQNEKARLRNKAVKSSLKTAVRKFREAADQGNVDEAVVLQRAACRQLDKAASKGVIHKNQAANRKSAIAQRVVELSAAK
>NC_013595.1|WP_012889006.1|2466373_2466862_+|MarR-family-transcriptional-regulator
MTEDPVDRIVLQWRRERPDLDPSPMGIFGRIYRIARLMGDRMEEVHGAHGLGRGEFDVLATLRRAGEPYTLSPKAITATLMLTSGGMTGRLDRLERAALIVRAPDPDDRRALRVSLTAQGLQVIDEAVAAGLGPQHEALAALPEEDRERLGALLRTLLGELE
>NC_013595.1|WP_012889005.1|2465394_2466300_-|EamA-family-transporter
MPAPRLALVAATALAPTVWGTTYIVTTELLPPDRPLLTALLRALPAGLLLLAMTRTLPRGNWWWRAPVLGALNIGLFFPLLFLSAYRLPGGVAGVLGAIQPLLVAGFTRAVLRETVPVHRVIAGITATVGVSLVVLRANAALDAVGVAAGVVAAAGMAAGVVLTRSWGKPPGVSDLALTGWQLTAGGLMIAPVALAAEGMPPALDGAAVGGYLWLGLVGTAAAYTLWFRGIARLPAAQVSLLGTLSPLTAALLGWIALGQSLSPLQLTGFALALGATVLGQFPAPRRTRVAADPQPAPSRP
>NC_013595.1|WP_012889004.1|2464142_2465126_+|DNA-polymerase-III-subunit-delta
MLLDMAATDPAPVILILGDEELLADRAVGEVIAAARATDPATEVYDLIGGKVEPGELTRLSSPSLFGDRSVVAIRSAQDLSKEVVSEIVSYAAHPAEDTALVLVHPGGVKGKALVDGVKKAGAHVVAVTKLTKPAERLAFVKAELKRAGRSIGADAAAALLDAVGNDLRELAAACSQLAFDTPGKTIDEAAVARYHRGRAEVSGFTVADSAVEGRLGDALEQLRWALATGTAPVLLVSALAGGLRSLAKVGGAPRNLRGGQLASHLGMPPWKIDRVQRQLNGWGPDGIARALQAAATADEQVKGGGADPAYALEHMIQTVVASRTGR
>NC_013595.1|WP_012889003.1|2463888_2464041_-|hypothetical-protein
MNSTTCRHACPRCGTTLDEGPIMYRCARCSRSVYAADVDTEFRRPLKAAV
>NC_013595.1|WP_148269521.1|2463218_2463677_+|nuclear-transport-factor-2-family-protein
MQGSPFSSGAFTPTAEDLQSVEAWFAEYDAHSAKVDVERMADMAMFPLNVVTDSADGEGLAAQWTRERFTRTMAEVMGGGEPGDIAMESTRTPHFLTKHLVVVVTDATMTVNGESYGMRYADLLVKAGGRWVFQTMVQGGWAEAWKETSQGA
>NC_013595.1|WP_012889013.1|2474128_2474971_-|DUF3097-domain-containing-protein
MYERDVLAEDWRRPLRGKIPQVPAELDLVVEDADGGFCGAVVACDKEAVTLEDRFGRRRLFPLEPAAFLLEGKVVTLVRPAAAPRGPRRSASGSIAVEGLRAQVAKESRIYVEGVHDAALVEKVWGHDLRVEGVVVEYLEGVDHLPSIVEEFEPGPGRRLGVLVDHLVPGSKESRIAAQVSSPHVLIVGHPFVDVWQAVKPSVLKIASWPSVPRGVPWKEGVIAALGWGLEPGDAWRRILGSVTTYADLEPELLGPVEELIDFVTVPGEDGQPRTHQEGS
>NC_013595.1|WP_148269522.1|2475026_2475590_-|hypothetical-protein
MGWIVGAWLVFVLSVIVGIAGFAGGIFSAITDAAPTSSFAPGQTVTVKLDPADKPAIYVSAATGTKFECQIQGDPGAVRLQQPSLDQTVTSDGVIWELALRVGVDKAGDYPLTCTTSEGASAKFGVGKELAADSVVGGAVALFAVPGLGFLLAVIVTIVVLVKRSGARKRQAAAAAGQWGQPGPYGR
>NC_013595.1|WP_012889015.1|2475947_2476961_+|heat-inducible-transcriptional-repressor-HrcA
MVDDRKLAVLRAIVEDYVSTNEPVGSKALVERHNLGVSSATIRNDMAVLEEQGYIAQPHTSAGRVPTDKGYRLFVDRLSQVKPLSSAERKAIETFLAGAVDIDDVVMRTVRLLAQLTRQVAVVQYPTLTNSTIRHVELVPLSERRLMFVLITNTGRVEQRVVELPDVVDETRVAHLRATLNACLDGCGLARVPDMVADLPERLPVEDRPLAATVLSVLLESLVDRHDEKIVFAGAANLAGADFTVGLRDVLEALEEQVVLMRLLGETSDLSALTVRIGSENPYTGLQGTSLVAAGYGSGDKQLARLGVLGPTRMDYPVTMGAVRAVARYVSQILAAS
>NC_013595.1|WP_012889016.1|2476973_2478116_+|molecular-chaperone-DnaJ
MAKSDYYGTLGVRRDASAEEIKKAYRRLARELHPDVNPDPETQERFKDITQAYEVLSDPNKRQMYDMGADPFASGAGAGAGGFGAGFPFSDIMDAFFGAAGGGGGRGPRSRARRGRNATIRVELDLRESAFGTTRELVVDTAVLCEVCTGSGAAAGTHPDTCDMCHGRGEVSQVTRSFLGQVMTSRPCPQCGGFGSIIRNPCQECSGDGRVRTRRTIKVRIPAGVEDGTHIQLAGEGEIGPGGGPPGDLFLEIVERAHEIFERRGDDLHCTVQIPMTAAALGTILTMETLDGAEELDIRPGTQSGQTIPLYGRGVQRLNETGRGDLLIHVNVETPSRLDPAQEELMRELAKLRGEERPPGKFAPGQQGFFSRLRDAFNGR
>NC_013595.1|WP_012889017.1|2478158_2478890_+|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MTVPVFLAEPADLARDEFTFGGPEGRHAAAVRRLRAGERLDLTDGAGTVAECVVRDAGRDSLRVEVLRRYEVAAPRPRLVVVQGLPKGDRGELAVEMMTEAGVDVIVPWAAARCVTQWKGERAVKSLNRWRSTAREAGKQSRRFHLPEVTEPATTAGVVALLSAAALGVVLHEEAASPLSTLELPGAGDIVVVVGPEGGVADEEIGAFREAGAVPALLGPTVLRTSTAGVAAAAVLQTRTGRW
>NC_013595.1|WP_012889018.1|2478894_2479563_-|hypothetical-protein
MTDSPDEYGELLRRVLSAEANSVVPSPDGLEIIRARVERRGLRGLMWWRAGASVAGAVLVAATIVMVVPQFREQVTRQVGDVNFTQSTSPDLSATSRAPSNGDNRLPAVPKPGPGTTAPAPMPTHSRSATPTSRPTPKPTSKTTPTPRSTPSPTCPTTLPDSTVVEPEELPEECRETQAPTPKPSEATTPSEHPCPVEQCPPTDDQSAPLPTESSTSVSSGG
>NC_013595.1|WP_043655278.1|2479559_2480039_-|SigE-family-RNA-polymerase-sigma-factor
MAVTALYSAHYRSLVRLAVLLVRDMATAEEVVQDAFVAIHGAWRRLRDTDKALAYLRQSVVNRSRSVLRHRAVVEKYAPKGMPDAPSAENGAIGEFERSAVIEALRGLPARQREALVLRYYGDLSEAQIAHAMGISKGAVKSHTARGMAALRTSLEQLS
>NC_013595.1|WP_043655280.1|2480324_2480675_+|histidine-triad-nucleotide-binding-protein
MSEADCLFCKIVAGEIPAKIVHETDRTLAFRDVNPQAPTHVLVVPKDHYPDAAALAAADHGLADDVIKAAHAVAEQEGVAASGYRLVFNTGAGAGQTVFHVHGHVLGGRGLAWPPG
>NC_013595.1|WP_012889021.1|2480766_2481831_+|PhoH-family-protein
MSETNDSSRTSPPRSKGPSRTQAKVVIPDDHSMVSLLGSRDELLRVIEGAFRADIHVRGNEITITGSPEESSIVVRLFEELSELVQGGAELTTDAVERSIAMLRMTSDRPAEVLSLDIISSRGRTIRPKTVNQKRYVDAIDRHTIVFGIGPAGTGKTYLAMAKAVKALQEKKVNRIILTRPAVEAGERLGFLPGTLYEKIDPYLRPLYDALHDMLDPDSIPRLMAAGTIEVAPLAYMRGRTLNDAYIILDEAQNTSPEQMKMFLTRLGFNSKIVVTGDVTQVDLPGGTLSGLRVVQGILDGIPDIHFSRLTSADVVRHKLVSDIVDAYGRYDETQRQSTPQAIKGVVKRPRETR
>NC_013595.1|WP_012889022.1|2481874_2482357_+|rRNA-maturation-RNase-YbeY
MSIEVNNESGVEVDEGLIVSLAGHVLERMDINPLAELSILIVDEEAMAVLHEQWMGEPGPTDVLSFPMDELRPGPGSGARQEGDAPTDPALLGDVVLCPQVAAKQAAEAGHSTEAELELLCTHGILHLLGYDHAEPEEHKEMFGLQGELLESWREVRPQR

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Crispr_ID: NC_013595_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_20

2758208-2758290

Orphan

Consensus_repeat	Method
GCTCATCCGGCCGCGCGGAGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_20

>merge|NC_013595|20|2758208-2758290|CRISPRCasFinder
GCTCATCCGGCCGCGCGGAGCCGCACCCGTCGTGCTCGCCCGCGTAGCCGCATCCGCCGTGCTCATCCGGCCGCGCGGAGCCG

>NC_013595|20|20|2758208-2758290|CRISPRCasFinder
GCTCATCCGGCCGCGCGGAGCCG	CACCCGTCGTGCTCGCCCGCGTAGCCGCATCCGCCGT
GCTCATCCGGCCGCGCGGAGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012889239.1\|2749199_2750030_+\|phytanoyl-CoA-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|368580
NC_013595.1\|WP_012889253.1\|2765724_2766927_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_013595.1\|WP_012889251.1\|2762484_2764113_+\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379084
NC_013595.1\|WP_148269535.1\|2752444_2753254_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_013595.1\|WP_012889246.1\|2756864_2757554_+\|adenosylcobinamide-amidohydrolase	unknown	unknown	gnl\|CDD\|376682
NC_013595.1\|WP_169369288.1\|2771072_2771216_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012889257.1\|2769315_2769963_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_013595.1\|WP_148269040.1\|2758354_2760298_-\|hydantoinase-B/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|376810
NC_013595.1\|WP_012889243.1\|2753531_2754497_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238563
NC_013595.1\|WP_012889256.1\|2768432_2769086_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|225462
NC_013595.1\|WP_169369286.1\|2757603_2758194_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NC_013595.1\|WP_012889238.1\|2748068_2748983_-\|TIGR03621-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|200301
NC_013595.1\|WP_012889255.1\|2767586_2768291_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_148269042.1\|2766936_2767647_+\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NC_013595.1\|WP_043651868.1\|2756008_2756815_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224045
NC_013595.1\|WP_148269537.1\|2764190_2765645_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_043655390.1\|2754866_2755913_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_013595.1\|WP_012889258.1\|2770135_2770981_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|225136
NC_013595.1\|WP_012889240.1\|2750019_2751021_+\|phosphotriesterase	unknown	unknown	gnl\|CDD\|238295
NC_013595.1\|WP_012889241.1\|2751084_2752284_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012889239.1\|2749199_2750030_+\|phytanoyl-CoA-dioxygenase-family-protein	gnl\|CDD\|368580	pfam05721, PhyH, Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.	7.56663e-16
NC_013595.1\|WP_012889253.1\|2765724_2766927_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.20788e-39
NC_013595.1\|WP_012889251.1\|2762484_2764113_+\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|379084	pfam13240, zinc_ribbon_2, zinc-ribbon domain. This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. pfam12773.	0.00102833
NC_013595.1\|WP_148269535.1\|2752444_2753254_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	4.27043e-21
NC_013595.1\|WP_012889246.1\|2756864_2757554_+\|adenosylcobinamide-amidohydrolase	gnl\|CDD\|376682	pfam01955, CbiZ, Adenosylcobinamide amidohydrolase. This prokaryotic protein family includes CbiZ which converts adenosylcobinamide (AdoCbi) to adenosylcobyric acid (AdoCby), an intermediate of the de novo coenzyme B12 biosynthetic route.	5.07481e-56
NC_013595.1\|WP_012889257.1\|2769315_2769963_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.12816e-12
NC_013595.1\|WP_148269040.1\|2758354_2760298_-\|hydantoinase-B/oxoprolinase-family-protein	gnl\|CDD\|376810	pfam02538, Hydantoinase_B, Hydantoinase B/oxoprolinase. This family includes N-methylhydaintoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase EC:3.5.2.9 which catalyzes the formation of L-glutamate from 5-oxo-L-proline. These enzymes are part of the oxoprolinase family and are related to pfam01968.	1.15245e-163
NC_013595.1\|WP_012889243.1\|2753531_2754497_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238563	cd01143, YvrC, Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.	7.2135e-57
NC_013595.1\|WP_012889256.1\|2768432_2769086_-\|NAD(P)H-binding-protein	gnl\|CDD\|225462	COG2910, COG2910, Putative NADH-flavin reductase [General function prediction only].	8.89849e-53
NC_013595.1\|WP_169369286.1\|2757603_2758194_+\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	1.03573e-24
NC_013595.1\|WP_012889238.1\|2748068_2748983_-\|TIGR03621-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|200301	TIGR03621, F420_MSMEG_2516, probable F420-dependent oxidoreductase, MSMEG_2516 family. Coenzyme F420 is produced by methanogenic archaea, a number of the Actinomycetes (including Mycobacterium tuberculosis), and rare members of other lineages. The resulting information-rich phylogenetic profile identifies candidate F420-dependent oxidoreductases within the family of luciferase-like enzymes (pfam00296), where the species range for the subfamily encompasses many F420-positive genomes without straying beyond. This family is uncharacterized, and named for member MSMEG_2516 from Mycobacterium smegmatis. [Unknown function, Enzymes of unknown specificity].	2.27325e-87
NC_013595.1\|WP_148269042.1\|2766936_2767647_+\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	7.75604e-73
NC_013595.1\|WP_043651868.1\|2756008_2756815_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	3.497e-95
NC_013595.1\|WP_148269537.1\|2764190_2765645_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.12037e-97
NC_013595.1\|WP_043655390.1\|2754866_2755913_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	4.07744e-74
NC_013595.1\|WP_012889258.1\|2770135_2770981_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|225136	COG2226, UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism].	2.22398e-28
NC_013595.1\|WP_012889240.1\|2750019_2751021_+\|phosphotriesterase	gnl\|CDD\|238295	cd00530, PTE, Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site is located next to a binuclear metal center, at the C-terminal end of a TIM alpha- beta barrel motif. The native enzyme contains two zinc ions at the active site however these can be replaced with other metals such as cobalt, cadmium, nickel or manganese and the enzyme remains active.	5.78097e-100
NC_013595.1\|WP_012889241.1\|2751084_2752284_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.89354e-69

>NC_013595.1|WP_169369286.1|2757603_2758194_+|Uma2-family-endonuclease
MRIERPAAHVIRTVLPGRPPFTVADLLRFPDDGNRYELFEGSLLVSPPPTPVHQLVVMRLVRLLEEAGGPELAPLPRINLHVGTADFLVPDVAVVPGVLAAGAEAAFAPRDVVLAVEVVSPHTRRRDRVMKPSAYADARIPFYWRVEPAEGPAVYVHELDGEGYRLVRRCEAGQVATVTAPFRASFDPAVLARPPA
>NC_013595.1|WP_012889246.1|2756864_2757554_+|adenosylcobinamide-amidohydrolase
MGVPVKLSHRDEDGARLASLLWEFGPGWRAISSAMVGGGIGPAGWVLNAQVIGGYARMDPVDHLLEMAPPGPGVGMLTAASVDHFTRAADGGAEAVATVGLRVPTWAAAPDGAADPELAPMYLPGTVNIIVAVPVAMSDAALVNAVMTVTEAKSQALLEAGFPCTGTASDAVCVAVRDDGPEELFGGPRSLWGARVARAVHDAVRRGALDWADRSDITLKSRLITESAV
>NC_013595.1|WP_043651868.1|2756008_2756815_+|ATP-binding-cassette-domain-containing-protein
MGRAGAGRGDRVSHVRVRDLAVVLETRTVLSGVGFEVRGGDWLAVIGANGAGKSTLLRALAGVLPCSGEVLVDDTPVRRLRARDRARLLAYAPQAPALPVDMTVFDYALLGRTPYIPYLGRESRRDREVTASVLERLDLSSFASRTLGHLSGGERQRVVLARALVQQAPVLLLDEPTTALDLGHQQQVLELLDRLRLADGLTVVTTLHDLSLAGQYADSMMLIAGGRVAASGTPAEVLTERLIGEHFDARVRVGTGAGGRPQVHLERP
>NC_013595.1|WP_043655390.1|2754866_2755913_+|iron-ABC-transporter-permease
MDGVPVRRAAGARPLASLAASGVLLASMLAALLIGAADIPPEKVALQLLDWLPFVSADSGLAPVEQGLLAEIRLPRVLLGAIVGGLLAIAGAGYQGVFRNPLADPYLLGAAAGAGLMTTTAIVFMKGDETALPIPAAAFAGAIGGVLLAYALGNVAGRGGGTATLVLAGVAVSSFLTAIQTFLQQLRVDELQRIYAWILGDVGGGWSQIALVAPYAVVSVVIMLLHGRLLDVLSVGDDEAVSLGLNVARVRLVVLLAASLATAAAVAVSGLIGFVGIVVPHVVRRLAGGSYRTVLPLSLIGGAAFLVLADLIARTVLAPAELPIGVVTAFVGAPFFVAVLRVTRRVET
>NC_013595.1|WP_012889243.1|2753531_2754497_+|ABC-transporter-substrate-binding-protein
MRPVRTAFAGVLLGALTLAGCGQSPAPATPEAAGSGAAATSPAASGAADFPVTVEAGNGSIAIAKRPERIVSLSPTATESLFAVGAGAQVIAVDDQSNHPAEAPKTDLSGFKPNAEAIIAKKPDLVVLANDADNIVAELTKVNVPVLLEPSATKLDEAYDQIADLGAATGNKAKADEVVAGMKKQIDELAAAAPKDKKLTFYHELDTTPYSATSTTFIGQIYGLFGLTNVADKAPDAAGGYPKLSAEFVAQADPDLIFLADTKCCAQSKDTLAKRPGWSKLSAIKNDQVIALDDDVASRWGPRVVDLAKQVGDAVQSAATE
>NC_013595.1|WP_148269535.1|2752444_2753254_+|Gfo/Idh/MocA-family-oxidoreductase
MVHAPMLAAGPDTRLVGVWARRPEAAARFGVPVFERLEELFDNCEAVAFSVPPAVQAELGVLAAKAGKALLLEKPLAADLDGARRLADAVGEAGVASQMVLTWRYSAATRSFLARVSAIEPFGGYAANISGAMLGGDFATPWRLERGAILDVGPHMIDMLDAALGRVTGVRAHGNPLGWVGLLLEHETGAVSEASLCMSAPGETPPSNVDIYGRLGRESINGEQLGPDVFAVMLSEFAETVSRGGGHPLDAAHGLRLQEIIAAAERQLS
>NC_013595.1|WP_012889241.1|2751084_2752284_+|cytochrome-P450
MITASDFDVSAAWHVAAPYDFLRRLRHERPVFHSEHLGAYVITRHEDVRAAYGDPRRFSSEGSLTISRSLAEETRRVLGEHGSFLSSFVANVDPPAHTRLRRSVSRAFTPRAVAAMEGLFRDLNEELLDRVAPRGAGDFVAELAHVPSVKLTARFIGVPEADEALVQKHVKDWFQLFLSPQPPDRQLVLADSFLAYLDYVDKLVAARAAEPRDDFVSLMTSLIGTELSHREVVELISTILLGGNDTVPNQLGNSVLRLLREEIWPVPPAMIQNAVEECMRVDGASLGSFRHARTDVEMHGVTIPAGSLCLLSTDSAAHDETVFPEPERFRIDRGNADAHMTLGYGIHFCVGAALARLQLRTALEVLGRRLPGLRQAPGSPVAYRTSIVGRGLAALHVEW
>NC_013595.1|WP_012889240.1|2750019_2751021_+|phosphotriesterase
MRAERREPSAGTETVNGPVEDLGATLMHEHVFGLSPEILWNWPDIPEGWDLERRAREAADKLTELKRHGIDSIVDLTVIGLGRYVPAVRRVAELTEVNIVVATGLYTYDALPPYFGNRGPGSLFGGPDRLAEFFVRDITDGIGDTGVKAGILKCASDHLGMTAGCERVFRAVAEAHRATGVPISTHSHSASGGGLEQQRLLAGAGVDLTRVIIGHAGDSTDVAYLEELIAGGSYLGMDRFGIETISSFEDRVAVVAKLAERGHAGRMVLSHDSYCFNDRFDHDVVRRRHPNYHLLHISRDVLPELRRRGVTEEQIRQMLVGNPRDIFARREPY
>NC_013595.1|WP_012889239.1|2749199_2750030_+|phytanoyl-CoA-dioxygenase-family-protein
MADNTPVRDVTDGEAAFFKDNGWVRLPRLVGPDHVALLRERALSRLRDRPRAVTSKVDQAFGQSRDIAETDGHFRELALAPALGRAATRLLHGVAGVRVQVTNLLIKEPERGSRAGEDPDGRDRTGGGHGATEFHQDFPWMPMDRSAMLTVWLALVDVPADMGSLRFYGGSHRHGLLGRSFTRDGDDQLSQHPWLGELDLSPPLDLAAGDATAHHALTVHGAAANRRDSARLSFTVTYFDADALYTGTPYGQTDGLGLTVNRPFDHPKFPVVPYEG
>NC_013595.1|WP_012889238.1|2748068_2748983_-|TIGR03621-family-F420-dependent-LLM-class-oxidoreductase
MDRPFRFAAVVREAESARAWADKARRLEGSGFDVLLVPDHLVGPRFAPVAAMTAAACATSRLHVGTLVFANDYRHPAVLAKEAATVDLLSEGRLELGLGTGWMAADYVSAGLALEPPGTRVGRLAEAITVLKGLWADGPFTFHGEHYRITGLEQWPKPARRPHPRLLLGGGGPRMLGLAAREADVINLGMRVRADGTGPDGMDGGLEAFLAKVDVVRRAAGDRYDRIELGTSIQQLGVRRPDEPWSAADSSRQDETPQVLLGTRQDITDKLRYWRDTHDLSYFVLHHERDLEAFTPIAEELAGR
>NC_013595.1|WP_148269040.1|2758354_2760298_-|hydantoinase-B/oxoprolinase-family-protein
MDGPARGDHERDPHGGGQVNDTPATGTDGAASRGTGEPAPRAPGPHGDGGSGETDPRAPGPRGDGDARETDRHGPGPRGDGGARDALTAEVLRNALVVAAEEASIVVVRSAYSTFIVEGSDASAAILDAGGRLVAQSMATTLMNSMALKVALPELLADIPAGTMRPGDVFVLNDAYRGGVHTNDLLVYRPVFVGGVPAYFTATMIHVSDLGGLSAGGMAPLATDIFLEGLQLPPVRLATERGVEATVEAILRANSRTPDKVMGDVRALIAGTAVAAARVEALIAEYGPAGLAGRIDDYLDYTETRTRTALAALPAGRYEASYLIDDDGIDAGTPHTVRVAVILEPGAGAVLDFEGTGPQVPAAINSSSSQSLAAAVFAVRCFLDPSIAMNDGCLRAIEVRLPPGSLLNACSPYPCGGRFVPVYAAMEAIFQALSDAMPDRAIAASGILQPFSIAAVRAPYWIHLSYDFGGVGARQGKDGPDSTGVHFGIGRNSVPQAEPVETRCPLIVESVETVPDSGGPGRHRGGLGSRTVIRFLADAHVTTRGDRLRNAPPGRSGGLPGRVGGFYRRHPDGSLERLGSKVNNALFAAGEAFVIETTGGGGIGSPYDRPLDEIEADLRTGRITARGALTDYGVAVRDDGTVMREAG
>NC_013595.1|WP_012889251.1|2762484_2764113_+|trypsin-like-peptidase-domain-containing-protein
MRRSGSALTLLGGLVLAVAAMTPALAHEHPSGITDLVTPAVVRVEAKARVDITLLDHIGELVHVERSYEVPIGTGTGTVVTPEGGVVTLTRVVRTDKDIAVYAANKIFAEHHKVKIPADFERHKIKNDQLNHHLQECYPPKQPTATCIVDITTEIHVFPNISPPDKEGFKAEIVRADSRPDGPAVLMSVGRADGGAGLPTAPLAATVPDKEGSPVAVAGFTGRPAVNLPETVDIAHLRAGGAGTGGRQFKDPENKVDEPVKLGALIDKGLIGGPVIEDKKGEVVGLLVGGGKDGRMIGVREISKALAEAKVAPRRGPIDAAFEQALTRFHTKYYGDAVPAFQRVLDLYPGHTVAAAHLKTAQQKRGTAEDEGVRKAGAPGGDEGGEPPLWPFLAAGGVLVAAVLAGALLLWRRRSPPGPEEGPPGNGHLGTTRPGDTRPGTTPVPIAGPPPAPRRSPLDETADPTVVVSRSFPALPKTPPTSPGQPVLVARDPGAKPADPAAHRHPGAKPSDTAAQKYCTACGMRLGPAHRFCGYCGHPSET
>NC_013595.1|WP_148269537.1|2764190_2765645_+|protein-kinase
MAVVYLAVDSRLNRRVALKILNPLLGEDDRFRQRFVLESRTVASIDHPNIIPIYEADSAEDGTLYIAMRYVDGPDLRRLFYDRGPMPISQVNRIFAQVAAALDTAHAHDLIHRDVKPANILIAGHTEGDHAYLTDFGITKHRTSISGLTQTNQFIGTPRYMSPEQINKEHIDGRCDQYGLACVVYEALAGRLPFQRDNEIALLWAHLAESPTPLSTLRPELPMEVDGVMARALAKSPEQRYDTCTQFVAELRDAISGQSYQLSQSARPVKPVKENRGPRSGGRGILIGAGVAIVAIIALLGVLAAFLRGGGDAWVPYAGSAAVPIGFEHPEDWTPRPHADVFMVASPKAGEFDALFATPVTADWAAVNEIIKDTPEEATGIYAQTLDTLDPRGGAQQLQETLQSSLPGTVNVYSEVVQVLVGGKPAVRLEGSITDPQRGGKLEFTGWAVERPDEPALMIYFCAPGTCDDALANRLVRSVSFPAS
>NC_013595.1|WP_012889253.1|2765724_2766927_+|two-component-sensor-histidine-kinase
MAVPLPLVRHPRTVSLTRHLRTVSKIDLLIGCAIIALGTLEAFTVATEYGATETPELWWIGQAVVTGVLVWFRRKAPVAVYILMILAQYAWHRQGYEHCQVWQLASLLIVFHTVGAELPFKPGLAWAVTGILVFDSGAVDHRLLPFDEVIFLTVVFGAAYLTGLAVHAHATRARRLADHAAQVERDRERQAAEAVAEERVRIARELHDVVAHSVSMMVMQAGVLRRTQVGENEVLLGIERMGREAVEELRVMLGALRMPLDEAIPQPGLALLPGTVSTLVSSGLRITLDVSGEPVRLAPGLDLSAYRIVQEALTNAVKHACESEIRISISYHAGRVELEVVDGGGSASSGLSTGNGLVGMRERAALFGGVFEAGPRPEGGFRVHASLPISQEAFANERIG
>NC_013595.1|WP_148269042.1|2766936_2767647_+|response-regulator
MRVPRTSRRSAERGEEVSIRIVIADDQAMVRVGLKLVVESEPGMEVVGEAADGLEAVTVARRTRPDIVLMDISMPRMDGLTAARKLLDWPDPPKVVMLTTFDTDENLYAALRAGTSGFLLKVSPPEQLVEAIRVVVGGDALLDPAVTTRVIASFAGRHDPAPPPQLADLTPRELEVLRFLARGLTNAEIAGQLFVGEATVKTHVARVLMKLHLRDRAQAVVFAYESGVVRPGAAVG
>NC_013595.1|WP_012889255.1|2767586_2768291_-|hypothetical-protein
MFKDSADFRRVAAGTLLIVAPLLQAVAVVLDPGTWGDDREAVSYGVNPTLAQVESAMYHWAYLLMALAALGLLHVMRRRSVVFGHIVGPLTILGYINLSGLLLVDPVEWWLGRHNSPEKAQLILDEMLNLPGVVFGFQMPWVFLAIFGLPILVIGVWRAGFAHWWVPLVVGVGYASSMAVPYGPVTVVLWAMPVVALGSLGVKMLRMSREEWVSFYPTAAPGRTTPDSYANTTA
>NC_013595.1|WP_012889256.1|2768432_2769086_-|NAD(P)H-binding-protein
MSKIVVFGAGGRAGRRTVAEAVARGHQVTAVVRDPARYEGPAGDEVTLVAGDVTRADSVAAVAAGHDAAISAAARLDVPAEEFYVGAAHALLDGLAQAGVGRLVVVGIGTLLETAPGVRVMDAPGFPAEARDFSLGHAAELDVLRAADTGIDWLMVTPPPTLLDDEAARTGRYRAGGEQVLPGGEEAGLLSYADLAVALVDEIENPKHHRTQVAVAP
>NC_013595.1|WP_012889257.1|2769315_2769963_-|TetR/AcrR-family-transcriptional-regulator
MSPRKAAALRDGDGGRTLREHLIAAAERLISQRGTAGLTVRDIAREAQVADGVLYNHFADKEELLALALHAHVQSVERELGELPSRAGTGTVEGNLRAYLIHGLALHAAILPAFAGLISRPEVLTLFAGMPNPVGNGLGLRTALAGYLRAEQDLGRLAPDAGAEAAATMIVGACHELVLPHLLWGREPAAFEIPPGYVDDLVTTLMKGLAPARPA
>NC_013595.1|WP_012889258.1|2770135_2770981_-|methyltransferase-domain-containing-protein
MSSIANTEQADAWNGYEGNHWADHQDRYDAVNSGFNDHLLAAAAVGERDRVLDVGCGNGQVTRLAARRARLGHTTGIDLSAPMLRRARACAADEGVANVTFERGDAQIHPFPDAGFDVAVSRFGIMFFADPVAAFANIGRALRPGGRLAFLSLREMGDNDLGPVLTAMADHLPARPATTGPGAPGPESLADPGRIREVLTGAGFEAVTSVPVDAPQLWGRDTEDAAAFLGAWGPVRFMLDQVDPAAAARARDALTEALRAHEEPGAVRLRGAAWLVTATRP
>NC_013595.1|WP_169369288.1|2771072_2771216_+|hypothetical-protein
MFIMRGRVEDVNREGAPPGRPPLDAEVGYDTSRIEDALVAEPWWRGR

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Crispr_ID: NC_013595_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_21

2943165-2943239

Orphan

Consensus_repeat	Method
CGCCGCTGACGGCGCCCGGCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_21

>merge|NC_013595|21|2943165-2943239|CRISPRCasFinder
CGCCGCTGACGGCGCCCGGCCCCTCGCCAGGCCCGGCCGGACGGGCAGGCGCCGCCGCCGACGGCGCCCGGCCCC

>NC_013595|21|21|2943165-2943239|CRISPRCasFinder
CGCCGCTGACGGCGCCCGGCCCC	TCGCCAGGCCCGGCCGGACGGGCAGGCGC
CGCCGCCGACGGCGCCCGGCCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012889417.1\|2943426_2943810_+\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|376809
NC_013595.1\|WP_012889422.1\|2948647_2948953_+\|urease-subunit-gamma	unknown	unknown	gnl\|CDD\|376347
NC_013595.1\|WP_012889411.1\|2937972_2938917_+\|ROK-family-glucokinase	unknown	unknown	gnl\|CDD\|273246
NC_013595.1\|WP_012889420.1\|2946149_2947358_-\|ammonium-transporter	unknown	unknown	gnl\|CDD\|223083
NC_013595.1\|WP_012889425.1\|2950392_2952117_+\|urease-subunit-alpha	unknown	unknown	gnl\|CDD\|237305
NC_013595.1\|WP_012889408.1\|2935826_2936264_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176861
NC_013595.1\|WP_043655476.1\|2939923_2941006_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_086012345.1\|2935015_2935783_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277338
NC_013595.1\|WP_148269546.1\|2939156_2939819_+\|endonuclease/exonuclease/phosphatase	unknown	unknown	gnl\|CDD\|226098
NC_013595.1\|WP_012889409.1\|2936331_2937501_+\|ArsA-family-ATPase	unknown	unknown	gnl\|CDD\|223082
NC_013595.1\|WP_012889421.1\|2947539_2948574_+\|urea-transporter	unknown	unknown	gnl\|CDD\|377010
NC_013595.1\|WP_012889426.1\|2952124_2952814_+\|urease-accessory-protein	unknown	unknown	gnl\|CDD\|223900
NC_013595.1\|WP_012889414.1\|2941009_2941486_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_081453410.1\|2943818_2944166_+\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|223317
NC_013595.1\|WP_179949558.1\|2949762_2950386_+\|urease-subunit-beta	unknown	unknown	gnl\|CDD\|376370
NC_013595.1\|WP_012889406.1\|2933009_2934803_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NC_013595.1\|WP_012889415.1\|2941552_2942317_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224561
NC_013595.1\|WP_012889410.1\|2937493_2937928_+\|DUF5304-family-protein	unknown	unknown	gnl\|CDD\|375065
NC_013595.1\|WP_052316927.1\|2949024_2949723_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239507
NC_013595.1\|WP_012889419.1\|2944244_2946140_-\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|379231

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012889417.1\|2943426_2943810_+\|CrcB-family-protein	gnl\|CDD\|376809	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB). CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance.	1.01358e-23
NC_013595.1\|WP_012889422.1\|2948647_2948953_+\|urease-subunit-gamma	gnl\|CDD\|376347	pfam00547, Urease_gamma, Urease, gamma subunit. Urease is a nickel-binding enzyme that catalyzes the hydrolysis of urea to carbon dioxide and ammonia.	1.45792e-57
NC_013595.1\|WP_012889411.1\|2937972_2938917_+\|ROK-family-glucokinase	gnl\|CDD\|273246	TIGR00744, Glucokinase_Glucose_kinase., ROK family protein (putative glucokinase). This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General].	3.14666e-91
NC_013595.1\|WP_012889420.1\|2946149_2947358_-\|ammonium-transporter	gnl\|CDD\|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	2.05295e-143
NC_013595.1\|WP_012889425.1\|2950392_2952117_+\|urease-subunit-alpha	gnl\|CDD\|237305	PRK13207, ureC, urease subunit alpha; Reviewed.	0
NC_013595.1\|WP_012889408.1\|2935826_2936264_+\|SRPBCC-family-protein	gnl\|CDD\|176861	cd07819, SRPBCC_2, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	3.62547e-49
NC_013595.1\|WP_012889421.1\|2947539_2948574_+\|urea-transporter	gnl\|CDD\|377010	pfam03253, UT, Urea transporter. Members of this family transport urea across membranes. The family includes a bacterial homolog.	4.6117e-89
NC_013595.1\|WP_086012345.1\|2935015_2935783_+\|metallophosphoesterase	gnl\|CDD\|277338	cd07392, MPP_PAE1087, Pyrobaculum aerophilum PAE1087 and related proteins, metallophosphatase domain. PAE1087 is an uncharacterized Pyrobaculum aerophilum protein with a metallophosphatase domain. The domain present in members of this family belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.23433e-14
NC_013595.1\|WP_148269546.1\|2939156_2939819_+\|endonuclease/exonuclease/phosphatase	gnl\|CDD\|226098	COG3568, ElsH, Metal-dependent hydrolase [General function prediction only].	8.65615e-17
NC_013595.1\|WP_012889419.1\|2944244_2946140_-\|FUSC-family-protein	gnl\|CDD\|379231	pfam13515, FUSC_2, Fusaric acid resistance protein-like.	2.35473e-20
NC_013595.1\|WP_012889426.1\|2952124_2952814_+\|urease-accessory-protein	gnl\|CDD\|223900	COG0830, UreF, Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones].	3.49584e-42
NC_013595.1\|WP_081453410.1\|2943818_2944166_+\|CrcB-family-protein	gnl\|CDD\|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	4.77263e-24
NC_013595.1\|WP_179949558.1\|2949762_2950386_+\|urease-subunit-beta	gnl\|CDD\|376370	pfam00699, Urease_beta, Urease beta subunit. This subunit is known as alpha in Heliobacter.	2.67995e-56
NC_013595.1\|WP_012889406.1\|2933009_2934803_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	0
NC_013595.1\|WP_012889415.1\|2941552_2942317_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	1.46164e-32
NC_013595.1\|WP_012889410.1\|2937493_2937928_+\|DUF5304-family-protein	gnl\|CDD\|375065	pfam17230, DUF5304, Family of unknown function (DUF5304). This family of unknown function is found in Actinobacteria.	2.03255e-07
NC_013595.1\|WP_052316927.1\|2949024_2949723_+\|hypothetical-protein	gnl\|CDD\|239507	cd03414, CbiX_SirB_C, Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase, responsible for the chelation of Co2+ into sirohydrochlorin, an important step in the vitamin B12 biosynthetic pathway. CbiX often contains a C-terminal histidine-rich region that may be important for metal delivery and/or storage, and may also contain an iron-sulfur center. Both CbiX and SirB are found in a wide range of bacteria.	5.85732e-05
NC_013595.1\|WP_012889409.1\|2936331_2937501_+\|ArsA-family-ATPase	gnl\|CDD\|223082	COG0003, ArsA, Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning].	6.74892e-98

>NC_013595.1|WP_012889415.1|2941552_2942317_-|alpha/beta-fold-hydrolase
MPVMPGAEPYHHKGGQIGVLLCHGFTGSPQSLRPWGEHLAAAGLTVALPRLPGHGTTWQEMNRTRWEDWYAELDRTLADLRGRCTEIFVMGLSMGGCMALRLAQVHGAGIRGLVIVNPSVTSDVPLLRLAPLLGLVVPSVPGVAGDIKKEGAIELGYTRTPVRAAASLTRLWALTQAELGKVTQPVLVFHSPQDHVVKPASVRILRERLSGGNLNVVELNDSYHVATLDNDADRIFSGSLEFVHANASVPLQAD
>NC_013595.1|WP_012889414.1|2941009_2941486_-|hypothetical-protein
MTPQSDEDEVWRQIVASFNDTAVRDSADQPWPDSENLPSEPPRRVVKQSDEDERPPAEDLADTDADTDTEQADPDDEGHYVPPPPPPLPKTDTTTKIAWLALFGGPAYLLLSAALNWQLQGWMLFTAVAAFIGGFVALVVRMGDGPPNDSGWDDGAVI
>NC_013595.1|WP_043655476.1|2939923_2941006_+|hypothetical-protein
MLLLSPRLPAAHAEPASPPAAEAWQAPTSARLSSDGSLSDVAGASATSVWAVGQQSVWDIWQSRGAITHWDGVTWTEVGIRNDPTGAGLLRSVAAASTTELWAVGEGHDGLPYLARGDGAAFDRVTVDSLRVGDWLGGVAAAPNRMVAVGRRDKHPLVVTGTGSGKWKLTQLDGKGTLYGVALAGKSDGWAVGDTGGRPLITRLSGGRWKTFHVPDIPGGYLRDIHLDGPKRALAVGGVYDDSGRAGPLILSWNGKKWSRLTPPGGDVRLYGVTGDRKGRFWISGVDLERPGEAFLLRYDGHTVRPLRGAAAIVPRTIRLQSVAYLPGAGTVVTVGHVVDADGRYTDVIERLGTSERAKP
>NC_013595.1|WP_148269546.1|2939156_2939819_+|endonuclease/exonuclease/phosphatase
MKDDVAALGRVISAVRPDVLCVQEAPRFLCWRRRRGQLAASGGLTVAAGRRLGGVAVLVGPRVRLLHGEGHLLRCFLGLEQRAVAIAVVETEGRRVAVASVHLDLDRGARLCHATEALTLLRAVADRFGALPVLAGDINEQSHEPAWRHLAGHLTDCYPVSPRGDGLTFPARRPGKRIDAIFAAAELPVLSCGVAEADPADLVAATDHLPVVAELGRPRP
>NC_013595.1|WP_012889411.1|2937972_2938917_+|ROK-family-glucokinase
MALTIGVDIGGTKVAAGVVDDDGHIVEHLLRPTPATNPEQVAETIAEAVRELSKGREIEAVGLGAAGFVDETRSVVRFAPNLAWREEPLQKKVSDLVGLPVVVENDANAMAWGEAKFGAGRDESHLVCVTIGTGIGGGIVLDGALYRGRWGMGAELGHMQVVPEGRLCGCGNLGCWEQYASGNALVAEARAIAEADPARAAVLLKIAGGTPEHVEGHEVTEAAKQGDPAALAAFSAMAEWLAQGLCDLAAVLDPGCFVLGGGVSRAADLWIDQVREAFARNLTGRGHRPLADIRLAELGASAGLVGAADLARRR
>NC_013595.1|WP_012889410.1|2937493_2937928_+|DUF5304-family-protein
MTEKTDRTENDRDPLGSATEEAFKLFDTFQQKAARELRKNLIKGTMTGFGGAFSSGGSRGGSRDVWEEAVSEHDEYICRACPVCRAMAAQRESGGAVADHLMQAGSELFAAFRSAVDGLNKPTPAQRARERGREETPVEHIDLG
>NC_013595.1|WP_012889409.1|2936331_2937501_+|ArsA-family-ATPase
MSRVLLFTGKGGVGKTTAAAATATLAAGSGHKTLVVSTDTAHSLADALGATAGGEPTEISPGLHLHQVDTQKALERQWGDLRDYARGFFAELGLDEVTAEEITVLPGADEVIALLELREHARSGRWDVIVIDCAPTAETLRLLALPEALDWHVNRLLPVGRRLLRTLSPLIRRVAQVSVPEDHVVGAGERLHRGLLEVRELLTGPDASVRLVLTPEAVVLAEARRTLTSLSLYGYRVDAVIANRVFPAEGADPWRQRWVDAQARHLAEVEQSFAPLPVHIVPYLDAEPVGPAALARVAEAMYGEADPFAPPTVDPPLRITPEGELILALPLAEKSEVDLARKGDELIVNAGSHRRVLALPAALARRSVQEAVLRDGLLRVRFQSGGPDD
>NC_013595.1|WP_012889408.1|2935826_2936264_+|SRPBCC-family-protein
MADRTTSSITIGAGRSPIMTVIADFASYPEWAGQVKSARVLSADADGRPATVRFALDAGVISDEYTLAYTWHGEDSVDWNIAEAGKMVSGLTGSYRLADEGGGTEVTYELAVDLKVPMIGMIRRKAEKVIIDTALKGLKKRVEAS
>NC_013595.1|WP_086012345.1|2935015_2935783_+|metallophosphoesterase
MRVHVVSDVHGNAAALARAGEGADALVCLGDLILFIDYDDHSQGIFPELFGQERATQFIALRTAKRFDEAREMSAALWASLDGDPRDHIERSVRRQYGEIFAAMPTPAYLTHGNVDLPRYWPEYLREGHHVLDGQSVEIGGLRFGFVGGGLRTPYRTPNEIDDEEFARKVEAVGEVDVLCCHIPPAVPELLYDVVARRFERGSEATLEAIRRTQPRYALFGHVHQPLAARTRIGRTECLNVGHFRGRGEPFVLEW
>NC_013595.1|WP_012889406.1|2933009_2934803_-|long-chain-fatty-acid--CoA-ligase
MREYSVPVLVDVPASANLTDTVFRRAEREPGTVALRRKIGDDWIAVTAGEFRDQVASVAKGLIAAGIGAGDRVALMSRTRYEWTVIDYAIWAAGAASVPIYETSSSDQIGWIISDSGAKAVFVELESHEETVREALAELPDLKDVWRIEGGALEELIAGGAEVSDETLSERRTGRGAADLATIVYTSGTTGRPKGCSLTHDNLLFTARNVAAGPLEPLFTAAGRAALLFLPLAHVFARMIQLVLIETGTVLAHTPNMKNVAPDLQAFKPTFLLGVPRVFEKVYNGAEQKAAGDGKSKIFHAAADTAIAWSRAQSAGGPGLGLRLRHTLFDKLVYGKLRAATGGRLSAAVSGGSALGERLAHFFRGVGIEVFEGWGLTETSAPSAVNMPGANKIGTVGKPFPGVTIGIGDDGEVLVKGRHVFAGYWNDDKATGEAIDADGWFHTGDVGELDKDGYLRITGRKKEILVTAAGKNVAPAPMEDLIRAHPLISQAMVVGDDRPFVAAIITLDPEALEQWKGSNGKTGATIADLSTDPAILAEVQKAVDRANRSVSKAEQIKKFTVLDSDISEESGHLTPTLKVKRNIVMRDFAEHIDSLYG
>NC_013595.1|WP_012889417.1|2943426_2943810_+|CrcB-family-protein
MKISRPALAAVACGGALGALARHLVHAAFPNPPHALQWTLLVVSVTGCLLIGLLTVWIERHPGHPLVGPFLSTGFLGGFTTFSSYAVNVEDKFHSGDTGVAVIHLVLTPVLAMIAVFVGTAVARRVM
>NC_013595.1|WP_081453410.1|2943818_2944166_+|CrcB-family-protein
MLVLLGGSVGAALRHLLGIWIPARFPWAIFVANVSASFLLGLVAAGTVAGRLPEWLLLLAGTGFCGALSTYSTLANDTLRLAEKGERRLAVANMGINVVFGLVAAFIGAALGRAL
>NC_013595.1|WP_012889419.1|2944244_2946140_-|FUSC-family-protein
MDVTADGWLSRTLRPKRVPVPWAAAVRAGAVISAGVAAGVVAGNPRMGMLLATGALAAAMRDRHPSYRLRLVHITVAVLGGAVGTATGVAFHDRGWWTVAALVGAAFVSGAISAIGSALSAAGMNLLVTASVWSALPLREPWWWPPLLYMAGGAGVLVLALAAWPVRAGTAERAAVARVYREIAAMMDAGDAGRAWTVLAPAVSDAYDVLTGYRLSAPGRDSESVRLMGMLNAAQPLLEAVATMLRHGDAFPPGASAPVTALARAVASGAHGIPPPERRPETADERIFSRALAYAVSCLRGDAAPPAAPPGRRWGRDLSAVLTSPDTLGYALRLALCMGIATVLVSVVAVPHSYWVPMTVTLVFKPDFGSVFGRAVLRALGTLAGVAVGGVLLLLVPPGWPTVPVVFALGAVARIGIDRSYAMMSTAITPLVLILVESAAPAPLGMVLPARLYDTLIGCAIVLVAGYALWPGSWRVRVRGRLAGTVTAAADYLQAAFEAGRQPARQRRRLYRRFSELHKGMQQGLSEPPPAGSRTAAWWPEVVALQRISAAIIEAAVQARSGAAVPSSGDVTATVAGLRRLAAAVQDWPAPASPGPLPGSGPLAGVAQEIRTAWSALPGGRPRGPGARTAG
>NC_013595.1|WP_012889420.1|2946149_2947358_-|ammonium-transporter
MPTGLNTGDSAWVLVSTAMVLLMTPGLAFFYGGMVRSKNVFSMLFMSFVSISLVTVLWFAYGYGLVFGPDAGGLGLIGFGDFRFANIRPTDLTGSVPTYAYALFQLTFAIITVALISGSVAGRIRVGPWMIFSVVWVTLVYFPIAHWVFDSSGWIHRMGTLDFAGGLVVELNSGMAGLALAMALGPGIRYRRGEPPQPSNIPLVMLGLALLWFGWFGFNGGSALNDGPTAVTAFLSTMIAGCVGMLTWMFLEWLRSRRLSKLGSATGAVAGLVAITPSCAYVNAEGALVIGIVAAALCSMAVEWKFVLGYDDTLDVVGVHGMGGIVGTLLIGFFSTGVVGTAGLFYGGSGALLGKQALSIVVVAVYCFVVTFVIGKVVDRLFRLKETEAEQLAGSDLQFGTG
>NC_013595.1|WP_012889421.1|2947539_2948574_+|urea-transporter
MTGRDGSTRPVTAERGEFGKADVTSTTPVATAPHLRDLKPLTLLVAVVRGIGQVDFMASPWTGLVFIVALAAGNWRYAVYGVLGSAVATLTAYAFGAARDRVELGLEGFSGTLIGVAFVLYFGMSWMTTLLVVAGCVAGSVVTSALVTLLKPFNLPTFTAPFCIITSVMLLAAPSFERVRQGVTGPALPSAATGRTALTWNDIWQGMFNGIGQVFFQNKWYVGLVFLVGLVVGSWIAAVAAVVASLVGMAVAWVLGAPAADIAAGLYGYNAVLVGMALAGIFVVLTPVGGVYAVVGAIAATGLTAALTTFFTPFGGHTLTWPFVLVTWTFLAAVPALAWLRRAG
>NC_013595.1|WP_012889422.1|2948647_2948953_+|urease-subunit-gamma
MNLAPRELDKLLIYVVADLAAKRKERGLKLNYSETVALVSAAVLEAAREGKSVADCMELGKKVVGPADVMDGVREMLPLMQVEATFPDGSKLVSCHDPVGA
>NC_013595.1|WP_052316927.1|2949024_2949723_+|hypothetical-protein
MERETVLVGGHESRYGRAFGGLPGATVTAVGRDLHALTRRPAVVVPMTLGRDPGLAHQIAQILRWNGRGREPGELLLAPPLGTTAHLVGWLRAAAGRATGPAPAPPAGPRAVLVTAPSASAEDDAELFRVARLVRQHSGLRWVEVAFMDGDPDVAEGVARCRLLGARHVTAVPASFAEPSLPEGVSWAGPLLSAASLEELVGRRVETARERWDRDADDGLAAAHHHHHDHSH
>NC_013595.1|WP_179949558.1|2949762_2950386_+|urease-subunit-beta
MPRHERYIYGDGEIEINQGRRKVSLTVRNTGDRAVQICSHYHFFEVNRAISFDRDAAFGMHLDLPAGNAIRIEPGDTHNVNLVEYGGGLRVYGFSGLVDGSVRGDKAHRLALERMDIFGFLDVPAGQDGSPDGAAEKAPPKKAPAAAAKKAPAASAKKAPAASTRKAPAAAAKKAPAASTRKAPAASAKKAPAASARKAPAASRKKG
>NC_013595.1|WP_012889425.1|2950392_2952117_+|urease-subunit-alpha
MVSMSRKQYADMFGPTVGDRIRLADTNLVIEVEKDYNVGFYGDESVYGGGKTARDGMGSAPNATNHSGALDMVITNVVVVDPVLGVVKGDIGIRNGLIAGIGKSGNPNTENGVDPRLVIGPGTEVLSGEHTIATPGAIDSHVHLISPQQVEAALSNGITTLIGGGVGPSDGSRGTTCTPGPWGISRMLQSFENLPINIGLMAKGNGSRPGPLSEQILAGACALKVHEDWGSTPAVIDNALAIADEYDVQVAIHTDTLNESGFLEDTISAIDGRAIHTFHTEGAGGGHAPDLLRIAGEPNVMPSSTNPTLPYTVNSMDELLDMVMVCHHLSHDNPEDIAFADSRVRAETISAETVMHDLGVISMVSSDSQAMGRVGESFTRAFQIAHHCKELRGKLPEDSDRNDNFRVLRYLAKLTINPARTTGISDAVGSLETGKIADIVIWQMYGFGAKPYIVVKGGQINWAQMGDPNASLPTPQPVYYRPMFGAFGRALPATNITFMSQAGIEAGVPGKLGLERMIRPVRGCRTIGKQDMVRNDALPTIEVDPETYKVTLDGEHAAIEPATRLPLTQLYFIA
>NC_013595.1|WP_012889426.1|2952124_2952814_+|urease-accessory-protein
MNLASLLAQLQLTDSAFPSGLYTLSHGLEGYIQSGLAGPADLPGLLADLLRHAVGPGDATALVLAHRAAAEGDWDRLVAADRRLHAVKLTRELRSAATRTGRQVLDTAGRVFGGPAAGKLADLVRAGATPGNHAVVVGTVHAGLGVPERQAVAGDLFAFASSWTAAAVRMGRVDFRQAQAILYGAHPDIARAAAIALAARSPYDIHASVPLADIVSAAHERAEARLFTT

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Crispr_ID: NC_013595_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_22

2994893-2995111

Orphan

Consensus_repeat	Method
AACAACAATAACAACAACAAC	CRT

5 spacers

The CRISPR arrays of NC_013595_22

>merge|NC_013595|22|2994893-2995111|CRT
AACAACAATAACAACGGGGGTCGTGCGAACAACAACAACAACAACAATAACAACAACAACGGGGGTCGTGCGAACAACAACAACAATAACAACAACAACAACGGAGGCGGGAACAACAACAACAACAATAACAACAACAACGGAGGCGGAGGAAACAACAACAATAATAACAACAACAACAACGGAGGCGGGAACAACAACAACAATAACAACAACAAC

>NC_013595|22|1|2994893-2995111|CRT
AACAACAATAACAACGGGGGT	CGTGCGAACAACAACAAC
AACAACAATAACAACAACAAC	GGGGGTCGTGCGAACAAC
AACAACAATAACAACAACAAC	AACGGAGGCGGGAACAACAAC
AACAACAATAACAACAACAAC	GGAGGCGGAGGAAACAAC
AACAATAATAACAACAACAAC	AACGGAGGCGGGAACAAC
AACAACAATAACAACAACAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_043651968.1\|2987506_2989693_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_013595.1\|WP_012889454.1\|2986754_2987444_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375429
NC_013595.1\|WP_012889466.1\|3001375_3001741_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012889458.1\|2992020_2993046_+\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|274155
NC_013595.1\|WP_052316931.1\|2990801_2991749_+\|lactonase-family-protein	unknown	unknown	gnl\|CDD\|378416
NC_013595.1\|WP_148269072.1\|2998670_2999288_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239027
NC_013595.1\|WP_012889469.1\|3005492_3006776_-\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NC_013595.1\|WP_012889456.1\|2989754_2990654_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NC_013595.1\|WP_012889470.1\|3006793_3008440_-\|urease-subunit-alpha	unknown	unknown	gnl\|CDD\|237305
NC_013595.1\|WP_012889467.1\|3001737_3003294_+\|SSS-family-solute/sodium-(Na+)-symporter	unknown	unknown	gnl\|CDD\|271374
NC_013595.1\|WP_012889465.1\|3000599_3001364_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_013595.1\|WP_012889468.1\|3003831_3005463_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|224490
NC_013595.1\|WP_012889453.1\|2985616_2986699_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|234821
NC_013595.1\|WP_012889464.1\|2999336_3000521_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NC_013595.1\|WP_012889459.1\|2993243_2994101_-\|integral-membrane-sensor-protein	unknown	unknown	gnl\|CDD\|225837
NC_013595.1\|WP_012889462.1\|2997250_2998288_-\|3-deoxy-7-phosphoheptulonate-synthase	unknown	unknown	gnl\|CDD\|181535
NC_013595.1\|WP_043651961.1\|2976585_2979723_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|284995
NC_013595.1\|WP_012889451.1\|2979921_2981055_+\|DUF839-domain-containing-protein	unknown	unknown	gnl\|CDD\|253386
NC_013595.1\|WP_012889461.1\|2995905_2997108_+\|tRNA-4-thiouridine(8)-synthase-ThiI	unknown	unknown	gnl\|CDD\|234960
NC_013595.1\|WP_081453411.1\|2981207_2982332_-\|alkene-reductase	unknown	unknown	gnl\|CDD\|239243

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_043651968.1\|2987506_2989693_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	2.07605e-77
NC_013595.1\|WP_012889454.1\|2986754_2987444_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|375429	pfam17918, TetR_C_15, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins including SlmA proteins found in E. coli. Unlike other TetR proteins, SlmA functions not as a transcription regulator but rather as an NO (nucleoid occlusion) factor. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.	2.79735e-19
NC_013595.1\|WP_012889458.1\|2992020_2993046_+\|6-phosphofructokinase	gnl\|CDD\|274155	TIGR02483, ATP-dependent_6-phosphofructokinase_1, phosphofructokinase. Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis].	0
NC_013595.1\|WP_052316931.1\|2990801_2991749_+\|lactonase-family-protein	gnl\|CDD\|378416	pfam10282, Lactonase, Lactonase, 7-bladed beta-propeller. This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyze 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.	4.58807e-74
NC_013595.1\|WP_148269072.1\|2998670_2999288_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|239027	cd02109, arch_bact_SO_family_Moco, bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate. The specific function of this subgroup is unknown.	1.31366e-81
NC_013595.1\|WP_012889469.1\|3005492_3006776_-\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.42574e-151
NC_013595.1\|WP_012889456.1\|2989754_2990654_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.15725e-14
NC_013595.1\|WP_012889470.1\|3006793_3008440_-\|urease-subunit-alpha	gnl\|CDD\|237305	PRK13207, ureC, urease subunit alpha; Reviewed.	0
NC_013595.1\|WP_012889467.1\|3001737_3003294_+\|SSS-family-solute/sodium-(Na+)-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	7.22795e-89
NC_013595.1\|WP_012889465.1\|3000599_3001364_+\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	2.75286e-52
NC_013595.1\|WP_012889468.1\|3003831_3005463_-\|amidohydrolase	gnl\|CDD\|224490	COG1574, COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only].	4.87742e-129
NC_013595.1\|WP_012889453.1\|2985616_2986699_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|234821	PRK00719, PRK00719, alkanesulfonate monooxygenase; Provisional.	1.37618e-147
NC_013595.1\|WP_012889464.1\|2999336_3000521_+\|histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	1.16909e-71
NC_013595.1\|WP_012889459.1\|2993243_2994101_-\|integral-membrane-sensor-protein	gnl\|CDD\|225837	COG3300, COG3300, MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms].	3.83839e-37
NC_013595.1\|WP_012889462.1\|2997250_2998288_-\|3-deoxy-7-phosphoheptulonate-synthase	gnl\|CDD\|181535	PRK08673, PRK08673, 3-deoxy-7-phosphoheptulonate synthase; Reviewed.	0
NC_013595.1\|WP_043651961.1\|2976585_2979723_-\|hypothetical-protein	gnl\|CDD\|284995	pfam07693, KAP_NTPase, KAP family P-loop domain. The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side.	7.99703e-18
NC_013595.1\|WP_012889451.1\|2979921_2981055_+\|DUF839-domain-containing-protein	gnl\|CDD\|253386	pfam05787, DUF839, Bacterial protein of unknown function (DUF839). This family consists of several bacterial proteins of unknown function that contain a predicted beta-propeller repeats.	6.49679e-29
NC_013595.1\|WP_012889461.1\|2995905_2997108_+\|tRNA-4-thiouridine(8)-synthase-ThiI	gnl\|CDD\|234960	PRK01565, PRK01565, thiamine biosynthesis protein ThiI; Provisional.	0
NC_013595.1\|WP_081453411.1\|2981207_2982332_-\|alkene-reductase	gnl\|CDD\|239243	cd02933, OYE_like_FMN, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include 12-oxophytodienoate reductase, pentaerythritol tetranitrate reductase, morphinone reductase, and related enzymes.	3.27468e-154

>NC_013595.1|WP_012889459.1|2993243_2994101_-|integral-membrane-sensor-protein
MSHVDHFSHGLLTPVLAYVMSSIGCMLGLLLTARARATTGSHRTRWLIGAALSIGGTGIWVMHFVAMMGFAVGGGQIRYDVPMTIGSAVLAVVVVGAGLLLVSRGGERILPLLGGGVLTGLGVAGMHYIGMFAMNMSARVSYDPTLVGLSVVIAIAAATVALWFTLRVSGAPATGGAAMIMAIAVSGMHYVGMFAMEVQPQISLTPVAGARGVDFMLPVLAVVSLLTLGLLLAVILSPSAKELADDAALMAQLETRRSEGGQPLAPAAPAAETPRRPSLFDSNDG
>NC_013595.1|WP_012889458.1|2992020_2993046_+|6-phosphofructokinase
MRIGVLTGGGDCPGLNAVIRAVVRKGVSVYGHEFVGFRDGWRGPLEGDTMPLDIQAVRGILPRGGTILGSSRTNPIKIDGGVEKIKDNLAETGVDALIAIGGEDTLGVAKQLFDKGVKVVGVPKTIDNDLSATDYTFGFDTAVNIATEAIDRLHTTAESHHRALICEVMGRHAGWIALHAGMAGGANVILIPEKPFDIDRVCAYVESRFKTRYAPIVVVAEGAHPIEGQMALQAGELDSFGHVRLGGIGEVLAKEIEKRTGKEARTTVLGHIQRGGTPTAFDRVLATRFGLHAIDAVHDGHFGVMVALQGTDIVRVALAEATKELKTVPVSRYEEAEVFFG
>NC_013595.1|WP_052316931.1|2990801_2991749_+|lactonase-family-protein
MMAEVAYVGGYTPDTGGSGAGITLVELGSFARLGVTVAPGPSFLATHPRLPVLYAVGESEQGTVSVLARAGDGTLTPLARRPSEGSSPCHLAVDPSGTLLAVANYGDGTVSVHGIDGSGLLTDVSVFPYRDGAHAHQAVFGPDGVLYVTDLGADEVRRHLVGTRVTEHPDGPVRLAPGMGPRHMARSGEHWYVAGELDGTVRVYDDGWREIRAVPASAAEGPSHPSHLEVSGGFVYVGNRGPDTISVLSAITLEPVAEVPCGGVWPRHFAIDGDRMYVANQRSDGVAVLTMKDGIPQFDGEVFAVGTPSCVLPRA
>NC_013595.1|WP_012889456.1|2989754_2990654_-|MarR-family-transcriptional-regulator
MEEHIAAVRAFNRFYTGVIGVLHQGVLDTPYSLTEVRVLFELAQREHVEAGELRRLLGLDAGYLSRMLGRFETDGLVVRERSAADGRRQVIGLTEAGGATFATLDARSAAQVRGLLEGVSEEDRRRLAANMAAIQEILTRAPKAEPYVIRPPRPGDLGWVVHRHGVLYSQEYGWGEEFEALVARIVADYVDGHDPRRDAGWIAEVDGERAGCVFCVHKDDETAQLRMLLVEPAARGMGIGGRLVEECLHFAKAAGYRRIMLWTRDVLTGARRIYRAAGFEPVEEHTADGFVEEVWARDL
>NC_013595.1|WP_043651968.1|2987506_2989693_+|MMPL-family-transporter
MKTDVRAVAAPPAPPPLRRLGHLLVRRRRLVMVVSLLATLAMAVLAAGAVGGLSLARFEAPGSESDRAGAELAERFGTGSADLILLVTARGGDVNTPAVAAAGQALTRELAASGGVAEAASYWTRGRPATLRSEDGRHALVVARIPGDADAVRSRILPELVPRLTRGNEVISVRSGGGEEVFRQTVPQARQDFVRAEMVIFPLVFVLLWLFLRRAVAALLPILVGVFAMVTTLALLRGALLFTDISTFALNLTLAMGLGLGVDYSLFVISRFREEVARGHDLHEAVARSVERAGRTVIFSGVTVAASVAVLLALPFDFLRSFAYAGIAVVAGGVIGAVIVLPAILAAVGRRVLPKRDRGERAEGFWHALATRVMRRPVVYGGAAALALLVLGSPFLGLRFGVADDRILPASAPARQTQEVIRAGFPAEETDALQIVSTGPAVDVAGYATTLSRLPGVAQVDSAAGSFAAGRRIGDGDPARFAGAEGTWLSVVPSAELMEADPVRLVEQVRAVPAPFGVLVGGYPAELADYRTSVVDRLPLLLAVMFAVTFVILFLMTGSVLIPLKATVLNLLSLSVMFGALVWVYQDGNLSGLLGFTPTGSLDPSIPILMFCIAYGLSMDYEVFVLSRIREEYGRTGDTPSAVAAGLQRSAPLITAAGAILALSFAVYASAQVLFVQMLGVGMAVAILVDATVIRAILVPAFMRLAGPANWWAPAPLRRLHDRLGLSD
>NC_013595.1|WP_012889454.1|2986754_2987444_-|TetR-family-transcriptional-regulator
MLAFVNGRPVPAEATHDRGTGWRMPEEQRTVRRQARGLRRMEEILDAAEQVIAEVGYAEMTTNTVAARAGMSPGSLYQFFRNKDEILQGLLSRFTDGRREHWETRLTGDVARMPLPEMIDRLIDEIVAYKTTRPAYWALLHGSSTGDRLAAASERLHLGIAGQLAELFGLRAPHLDGERRLVLAMMALAAVKAAMPLITAAPPARSQELITELKAMLLGYLTPALIPSL
>NC_013595.1|WP_012889453.1|2985616_2986699_-|LLM-class-flavin-dependent-oxidoreductase
MRFHWFLPTTGDGHHVRPATTTVAAGAAAARPATLDYLVQVAGAAEAAGFDAALTPVGAGCPDPLVACSAIAARTGRLRLLVAFRPGFTLPTLLAQQAQTFQEISGGRLLLNVVTGGDPEEQRAYGDFLDHDARYGRTEEFLAVLRRTWTGRRFDHRGVHYRVSGGGLATPLPGIPEIYFGGASPAAERVAAAQADVYLMWGEPPAMIAERVARMRRLAAEAGRDLRFGIRLHVIARDTAEEAWAHARRLLDGMDPGRIAAAQARFARMDSVGQRRMAGLHGGSADALEISPNLWAGVGLVREGAGTALVGSYAEVSERIREYGRLGLSEFILSGWPHLEEAWRVGDSVLPRLAAPVPAA
>NC_013595.1|WP_081453411.1|2981207_2982332_-|alkene-reductase
MSSTALTSRLFEPARLGALHLPNRLVMAPLTRNRASADGIPEPIMATYYAQRASAGLIIAEASTPNAVGQTYPDIPAIYNDAHVAGWRRVTGAVRAAGGTMFLQLQHGGRIGHPDTTGLMPLAPSPVAFPDPIFTPGGSRPGVVPREMTVAEIRSTVADFAAAARRAIDAGFEGVEVHGGNGYLIHQFLSEATNHRADAYGGSAAGRIRFAVEVVEAVADAIGPARVGLRIAPGVTANAMREHDIERVYPALVGALANKGLAYLHVVFADPAQPLFHRIRGDWPSVLIANPALPWPTPFPADGGRYAGERLLAAGADLISLGRAFLANPDLVERFRRGAPLNPVRTEHWYGGGELGYTDYPVLAAQEDRDPVVV
>NC_013595.1|WP_012889451.1|2979921_2981055_+|DUF839-domain-containing-protein
MLRRTLVRTGGVAAGAAFAGSLWQGAAHATPLRACGPYGPLGAPDADGVALPPGFTSRIVARTGRRVGGVLWHPAPDGGACFPDGDGWIYVSNSEIPLLGGATAIGFGPGGDVRGAYRILSGTNLNCAGGRTPWNTWLSCEEVLRGRVFECDPYGSRAAMPRLAMGRFKHEAAACDPDRQVVYLTEDEPDGCFYRFRPTHWGDLTSGRLDVLCASSETGAVTWQRVPNPAALLEATRHQVDAARHFDGGEGCHYADGVCFFTTKGDNRVWGYDAENERLEIVYDADTPLNGVDNITGTPGGDLYIAEDGGDMEINLITPDRVVTPFLRVAGHPRSEITGPAFSPDGSRLYFSSQRGARGDAAGTDGVTYEVSGPFRR
>NC_013595.1|WP_043651961.1|2976585_2979723_-|hypothetical-protein
MSEGLASAKSILETAPRVGTRRALVFLDPPPDPLPGLPPVSALAAAPPDVRLASALRAEGFAVDSGRSRGAQADGERVWEFLRSAQERDLLVVRLPGDDGWTSGQLGSMIGAFGRQAGETLAAAVLLIMDFGWSALDGSAAPVRQLAVAGEPRVAAAALTLTLKLGETLSGRAPSLTGVLAEGLATRAADLDGDGMISVGDLHAYALRHYETASAPRTPILIAYGAVTGVALTRARDLSTPPHAAFARVLARLGDPAPPASGAEIVRRIYELHLSEPARELLRRASLLDEGESIDEVLGDAAELRHWGLLGETTMFVHPDVRAFGYSRLSAAERAQTSAVLRRLRAGRRAVQPRARLTADRWTTEDQLGHRVYAEAIAAFVRHPETRPPLTIGVKGPWGTGKTSLMRMIQDLLDPGAAGDRPAEIHLPGSRRDRALTNAEVLARSRQRPRESTGQAEPGALPVRRADWRPTVWFNPWMYQNGEQVWAGLAHEIIGQVTRRLPLAERERFWLELNLARIDREAVRRRAYHLAMTRLVPLALGLVATLVLTGAFLTASALLPAFGALLRNAAAGIGSAGSVAVVAAGAVRLARFFRESADTAFQGLVRQPDLLSPGVAEGLAAEAVTTPGYGSRTGFLHLVQTDMRQVLDLIATEERPLVVFVDDLDRCSPGTVAQVIEAINLFLAGEFPNCVFVLAMEPEVVAAHVEAAYPELVGTMPDDGRSGLGWRFLEKIVQLPLSVPLLDDADRLPGFVRALLGMPGIAGPREPVECCLPGGATPRRHGRPPRATGLRSGEASAQARESGPPPRGSVPEPRGAVPEPRGAEDEAVPGSRAPVDVPLAVPRSRPVEPPDPALVSRLEDAIWALRPTAADLDEAARQAQEILGIEALDAIGGLASATREAADRVFDDLYSDENAYRAIEFVLPVMTFFNPREIKRYVNVFRFYSFLVYRRTLAGAAPASDGEVAKLAALTIHWPHLLSPLVKEVDGVSVLQRLERAADDDRGWERTVREAGLAGPETPGVAHLDTLRDLLSCPHPIAGLARHLL
>NC_013595.1|WP_012889461.1|2995905_2997108_+|tRNA-4-thiouridine(8)-synthase-ThiI
MTMSALGEPCVLLKLGEVVLKGNNRELFEQRLQANIKAALKDFDFKVDVRQRHGVIALFLPDGTTPEVADAVAERVAYVPGLVWIHRAWRVEKDPGAVTKAAIELLADRDDVRRGVSFAVRSRRRDKRFPLTSMEIDRSVGGELNDIYGLPVDLKNPELVVSIEVDRDEVFVFTGGTPGQGGLPVGTSGRGLVLMSGGIDSPVAAYRMMRRGLRVDFLHFSGIPFTTSESIYKAYALVRALDRFQGRSRLWVVPFGKAQQSIKASGQDRLAVISQRRLMLKTAEEVARRLRAGALITGDSLGQVSSQTLQNITAQDDAVDLPILRPLIGLDKTEIMAEARRIGTLEISELPDEDCCTLLAPRRAETAAKIADLRQIEKRLDAEELAVQLAGSLQEYKLEG
>NC_013595.1|WP_012889462.1|2997250_2998288_-|3-deoxy-7-phosphoheptulonate-synthase
MVIVMGPDATQGDVQAIVEIIGTAGGDAFVSRGVSRTIIGLVGDVAQFSALDLRGMRGVADVMRVTAPYKLVSRDNHPERSTVRVGGVPIGPGTVTLIAGPCAVETPQQTLEAAEMAKAAGATLLRGGAYKPRTSPYAFQGLGEAGLRILADVREQTGLPVVTEVVDAHDVELVASYADMLQVGTRNAQNFALLQAVGGIGKPVMLKRGMNATIEEWLMAAEYIAQRGNLDIVLCERGIRTFETATRNTLDVSAVPVAQRLSHLPVIVDPSHSGGRRDLVLPLTRAAIAVGADGVIIDVHPNPEQALCDGPQALVDDDLRELARVMRDFPPLVGKNPAGDVLASA
>NC_013595.1|WP_148269072.1|2998670_2999288_+|molybdopterin-dependent-oxidoreductase
MEQSETPQEETRLPPGQYVPRGRPVIHYGRVPTFRPATWEFRVMGATASGEQHRFTWPQFSELPRTTVMADFHCVTKFSIMGNEWRGVSTATLMELAPPAPGVKHVMIWAEYGYSANMRMSDFGRGHTLFALELDEKPISPERGFPVRAIVPHLYAWKSVKWVRAVEYLLEDRRGFWEERGYHNLADPWREQRYSYQEEPGEGPL
>NC_013595.1|WP_012889464.1|2999336_3000521_+|histidine-kinase
MWSTSAWVLLCALSTFLGFVLSRRRPASPRHPAGLPDEATFATLHITALAAPSLRAGLTRDSARKAIRHLRTLLGVSAIAVTDADGVLAWDGAAGCHRDHAPEHARTVFSSGRPYVVAGDAIACDTPGCAIRGAAVVPLTVDGRVIGALAAYDTEVSAGLVRTVTEVARWVSGQLELAELDSSRRRAMEAETRALRAQISPHFVYNSLTTIASFVRTDPERARELLMDFADFTRHALRRGGDFTTLADELRCVDRYLLLERARFGERLRFTVRVAPEVLPVPVPFLCLQPLVENAIKHGIAATGGSGEVRVVVRDAGPEAHISVEDDGLGMDPGRARRLLDDDPCQGPGEGGIGLANVDVRLRQIYGEGYGLVVETALGAGTKIRLRVPKLPTR
>NC_013595.1|WP_012889465.1|3000599_3001364_+|response-regulator-transcription-factor
MLRVLAVDDEVPALEELAYLLRHDPRIEHVSTAPGGITALQDMVQMIGTGERLDGVFLDIRMPGLGGLDLARLIGAFPNPPRLVFVTAHEDCAIQAFDLEAVDYLLKPVRADRLAEAVRRLECMTPATGEPVPEDVIPVELGGRTRFVSQQTVRFAEAQGDYVRLHTVDGNYLVRMSLAALERRWADSGFIRVHRSTLVSVRHVSELRFDGGRVTLQVGSETLPVSRRHTRQVREQLVRDRQLQDRSLSSGVLG
>NC_013595.1|WP_012889466.1|3001375_3001741_+|hypothetical-protein
MTVTRSPAQAAGTGTAGPLRPLGADVDADPDGWAEPGELRLRSIVAGQLSLAGRTLAAVAGILLGVAVLPWLGERAGIGASGAWLVLCLVPPPLWALLAVTHLRRAERIEREFVRAARDGG
>NC_013595.1|WP_012889467.1|3001737_3003294_+|SSS-family-solute/sodium-(Na+)-symporter
MSTAVVASLLGVAVVLLGSAAMGVVRPRRYATILDFYVAARAVGPWRNGAAISSEYTSAVSCLSLAGLIALHGVPMLWYSVGAAGGYVVVLILVVAPLRRSGTYTLSDFAQWRLGSPLVRRLVTGIVTVIGMICLVAQLQAAGVVLRLVTGLPPWAGGLATAVAAVAVALTGGMGSVTGLQALQFWLKLLIFAGCALVLWSAWRWGAAAPPAVPVPPAGPHLVQGHVLAGAGDPSPLGVLSVLVSCALGAMGLPHVIVRVYASPDGRSARRSVVAALAMLVAFYLLPPVYGVLGRVFTPGAPADVMVLVLPARMLPGPVGDALTGLLAAGAFAAFLATSCGVLVALGAALSPGTPRVARLARITRIGRFRGSVAGVALTALLLSWAAPHGSVILLVMLGFGLSAATLCPVLVLGIWWRGLSARGAAAGLVVGGGLVAVLVAVEGLAPAALVAGLGLPVRYPAPFVAPVAFLVMVVVSLATPGSVPPGVSRKLARMHLPEDLGDAGIDRSSRRPDRSSR
>NC_013595.1|WP_012889468.1|3003831_3005463_-|amidohydrolase
MRLDALFVNGRFTTLDPGRPEATRLGVFGGRIAGLNEELDGVTADLVVDLGGAPVVPGFNDAHHHLSMRGQRLRELDLRESQVGSLDELYAKVAERAAGLPPDAWVRGAGYDQNKLGAHPTREALDRASGGRPVWLQHVSGHMGVASTEAFARMGFSRVEDVPEVPGGTVGRDAAGLPDGLLTEQAQELANRVLRPVTHEDYIRGLALASRVAAAEGLTSFTEPGVGHGLAGNGSWDVAAFQEAVRQGLLLQRATLMPGSPNLHDVGNGQFGLDLGIGTGLGDERLRIGPVKLFSDGSLIGRTAAMCCDYQGEPGNRGLLQEDAEALRTFILRAHASDWQIATHAIGDHAVEVILDAYEEAQARHPRPDARHRIEHCAVTSDAQVARIARLGVIPVPQGRFISELGDGMLAALGPERARGCYRQRSFLDAGIPLPGSSDCPVTDGAPLLGIHDLVNQRTAGGVPFNPAEALTVAQALHAYTAGSAHAVHEDHLKGVLSRGRLADFAVLSDDLFAVPAERIRDLTVAATAVGGVLVHDAAGFAR
>NC_013595.1|WP_012889469.1|3005492_3006776_-|MHS-family-MFS-transporter
MSKTNARGAGIASFVGTSIEWYDFYIYGTASALIFGRLFFPEASPTAGVMASFATFWVGFLARPLGGVIFGHLGDRIGRKGTLVATLLLMGGATTLVGVLPTYESIGMLAPILLAVLRLVQGIAVGGEWGGAVLIAAEHAGPKRVFYAAFAQQGSPAGSILATGMFALVSLMPDEAFLSYGWRIPFLASAVLLAIGLVIRLKVEESPEFVKMRDQREVAKLPVAEVFRTAWPLVLLGIGASGVGIASAYFTNTFILSWATTDLGIAKGTMLNVLLIVAVVQFVTQPIGAVLGQKWGAARYMLIAFSALLVCTPITFLMVGTGSPTMATLGLALSIVFGGSSYAALAGFLAEVFPARVRYTGISLAYQLCGALIGGTAPMIAQALLGWSGTIWAVVIQYIAIILLTMACVAALHRRSAATAEPVPVGA
>NC_013595.1|WP_012889470.1|3006793_3008440_-|urease-subunit-alpha
MSSVSRDTYNKLYGPTAGDRVRLGDTCLWIEIERDDVPHGDELLGGCGKTLRDGLLAAPRGDRDSALDVVVAGVVLMDPVLGVRKTHIGVKDGRIVPFEGAVIDSHTAIVPGEGLIATPGVVDSHVHLSSPEIAPAALASGVTTVVGMGLGGVWDVGCNPAHNLHTLMSAWRGTPLNVAFLARGSSSSSTLLEEAVLAGAGGFKIHEDFGATPRIVDTCLGVAEQADLPVALHSDSMNESGYLADTVGATRGRTVHAYHVEGGGGHPDLLEILGEPNILASSTTPTIPYTTNTVGELFPMTMTVHRQNHHIDSDVEVTRTRLRVHGIAAENVLHDLGAISIVNSDSMGMGRVAETVRRTWQLAHLQALRAGTPGVDNARVLRYLAKLTLNPAIAHGLAHEVGTLQPGRLADIVLWHPAWFGTKPELVLKGGFVAHGVSGSGSGSTRLTQPRTYRPYFGGLGDAPSRLSRVFVAHEALDSAESRDALPTGLRYAAIRHSRGLTRADMCRNTATPQVEVPRDPGPVLVDGTEVGVAPATEVPLARLHHFA

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Crispr_ID: NC_013595_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_23

3141233-3141401

Orphan

Consensus_repeat	Method
GGACGGCTGCCCGAAATGGGCGGGGCTGTCGCCGTAGGAC	PILER-CR

2 spacers

The CRISPR arrays of NC_013595_23

>merge|NC_013595|23|3141233-3141401|PILER-CR
CTGCCCGAAATGGGCGGGGCTGTCGCCGTAGGGCCGCTGCGCGGGGTCGCCGGGATGGGACGGCTGCCCGAAGTGGGCGGCCCCGTCCTGGTGGGGCGGCTGCCCGGCGTGGGTGGGGGAGTTCCGGTAGGACGGCTGCCCGAAATGGGCGGGGCTGTCGCCGTAGGAC

>NC_013595|23|1|3141233-3141401|PILER-CR
CTGCCCGAAATGGGCGGGGCTGTCGCCGTAGGGCCGCTGC	GCGGGGTCGCCGGGATGGGACGG
CTGCCCGAAGTGGGCGGCCCCGTCCTGGTGGGGCGGCTGC	CCGGCGTGGGTGGGGGAGTTCCGGTAGGACGGCTGCCCGAAATGGGCGG
GGCTGTCGCCGTAGGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_081453108.1\|3155090_3156197_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_013595.1\|WP_148269551.1\|3135502_3136018_+\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|237810
NC_013595.1\|WP_148269553.1\|3157406_3158702_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340847
NC_013595.1\|WP_012889593.1\|3147453_3150975_+\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|235554
NC_013595.1\|WP_148269552.1\|3145890_3147219_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NC_013595.1\|WP_012889598.1\|3156366_3156942_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NC_013595.1\|WP_012889587.1\|3138957_3139638_-\|AzlC-family-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224215
NC_013595.1\|WP_012889584.1\|3136010_3136940_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_013595.1\|WP_043651988.1\|3134987_3135407_+\|TraR/DksA-C4-type-zinc-finger-protein	unknown	unknown	gnl\|CDD\|274340
NC_013595.1\|WP_012889594.1\|3151179_3152538_+\|discoidin-domain-containing-protein	unknown	unknown	gnl\|CDD\|277318
NC_013595.1\|WP_012889585.1\|3136962_3138540_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012889580.1\|3128101_3128959_+\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377456
NC_013595.1\|WP_012889590.1\|3142519_3144526_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012889579.1\|3127764_3128052_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|376765
NC_013595.1\|WP_012889596.1\|3153755_3154724_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223893
NC_013595.1\|WP_148269080.1\|3158794_3159787_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012889595.1\|3152538_3153759_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340928
NC_013595.1\|WP_012889582.1\|3131369_3134534_-\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235681
NC_013595.1\|WP_012889586.1\|3138649_3138961_-\|AzlD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377512
NC_013595.1\|WP_012889581.1\|3129001_3130900_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_081453108.1\|3155090_3156197_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.87362e-60
NC_013595.1\|WP_148269551.1\|3135502_3136018_+\|signal-peptidase-II	gnl\|CDD\|237810	PRK14764, PRK14764, lipoprotein signal peptidase; Provisional.	7.52209e-66
NC_013595.1\|WP_148269553.1\|3157406_3158702_-\|glycosyltransferase	gnl\|CDD\|340847	cd03820, GT4_AmsD-like, amylovoran biosynthesis glycosyltransferase AmsD and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.	4.60129e-110
NC_013595.1\|WP_012889593.1\|3147453_3150975_+\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|235554	PRK05673, dnaE, DNA polymerase III subunit alpha; Validated.	0
NC_013595.1\|WP_148269552.1\|3145890_3147219_-\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	1.48703e-173
NC_013595.1\|WP_012889598.1\|3156366_3156942_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	3.60815e-15
NC_013595.1\|WP_012889587.1\|3138957_3139638_-\|AzlC-family-ABC-transporter-permease	gnl\|CDD\|224215	COG1296, AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism].	2.89697e-29
NC_013595.1\|WP_012889584.1\|3136010_3136940_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	9.5245e-109
NC_013595.1\|WP_043651988.1\|3134987_3135407_+\|TraR/DksA-C4-type-zinc-finger-protein	gnl\|CDD\|274340	TIGR02890, conserved_hypothetical_protein, regulatory protein, yteA family. Members of this predicted regulatory protein are found only in endospore-forming members of the Firmicutes group of bacteria, and in nearly every such species; Clostridium perfringens seems to be an exception. The member from Bacillus subtilis, the model system for the study of the sporulation program, has been designated both yteA and yzwB. Some (but not all) members of this family show a strong sequence match to Pfam family pfam01258 the C4-type zinc finger protein, DksA/TraR family, but only one of the four key Cys residues is conserved. All members of this protein family share an additional C-terminal domain. Smaller proteins from the proteobacteria with just the N-terminal domain, including DksA and DksA2 are RNA polymerase-binding regulatory proteins even if the Zn-binding site is not conserved. [Unknown function, General].	6.18648e-22
NC_013595.1\|WP_012889594.1\|3151179_3152538_+\|discoidin-domain-containing-protein	gnl\|CDD\|277318	cd00839, MPP_PAPs, purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain. Purple acid phosphatases (PAPs) belong to a diverse family of binuclear metallohydrolases that have been identified and characterized in plants, animals, and fungi. PAPs contain a binuclear metal center and their characteristic pink or purple color derives from a charge-transfer transition between a tyrosine residue and a chromophoric ferric ion within the binuclear center. PAPs catalyze the hydrolysis of a wide range of activated phosphoric acid mono- and di-esters and anhydrides. PAPs are distinguished from the other phosphatases by their insensitivity to L-(+) tartrate inhibition and are therefore also known as tartrate resistant acid phosphatases (TRAPs). While only a few copies of PAP-like genes are present in mammalian and fungal genomes, multiple copies are present in plant genomes. PAPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	8.15507e-23
NC_013595.1\|WP_012889585.1\|3136962_3138540_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.70392e-111
NC_013595.1\|WP_012889580.1\|3128101_3128959_+\|DivIVA-domain-containing-protein	gnl\|CDD\|377456	pfam05103, DivIVA, DivIVA protein. The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype. These proteins appear to contain coiled-coils.	1.11383e-12
NC_013595.1\|WP_012889590.1\|3142519_3144526_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.26872e-103
NC_013595.1\|WP_012889579.1\|3127764_3128052_+\|YggT-family-protein	gnl\|CDD\|376765	pfam02325, YGGT, YGGT family. This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown.	0.000124121
NC_013595.1\|WP_012889596.1\|3153755_3154724_+\|hypothetical-protein	gnl\|CDD\|223893	COG0823, TolB, Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion].	0.00159997
NC_013595.1\|WP_012889595.1\|3152538_3153759_+\|MFS-transporter	gnl\|CDD\|340928	cd17370, MFS_MJ1317_like, MJ1317 and similar transporters of the Major Facilitator Superfamily. This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.5443e-69
NC_013595.1\|WP_012889582.1\|3131369_3134534_-\|isoleucine--tRNA-ligase	gnl\|CDD\|235681	PRK06039, ileS, isoleucyl-tRNA synthetase; Reviewed.	0
NC_013595.1\|WP_012889586.1\|3138649_3138961_-\|AzlD-domain-containing-protein	gnl\|CDD\|377512	pfam05437, AzlD, Branched-chain amino acid transport protein (AzlD). This family consists of a number of bacterial and archaeal branched-chain amino acid transport proteins. AzlD is known to be involved in conferring resistance to 4-azaleucine although its exact role is uncertain.	2.11107e-07
NC_013595.1\|WP_012889581.1\|3129001_3130900_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	9.43123e-14

>NC_013595.1|WP_012889587.1|3138957_3139638_-|AzlC-family-ABC-transporter-permease
MDTTTRSSAVRDGLGVGIAVGLSGLAFGAAAVTAGLSVAQACVLSLFAFTGASQFAMVGVVAGGGSLAAGTAGALLLGARNGLYGLRMSDLLAVRGWRRLPAAHGVIDETTAVALAQPDERSARTGFFVTFISIYLTWNLTTLLGAVGTSRVADPAVFGLDAVGPATFLAILWPRLTGSGPETRSLRLIAGGGAAIALATTPFTPPGVPVLIAAAAVLAVILRRPK
>NC_013595.1|WP_012889586.1|3138649_3138961_-|AzlD-domain-containing-protein
MTVWWAIVITCAGCYALKLAGLSAPRQVLDHPTVQRFAALVPVALLAALIAVQTFAHGQQLHFDVPRTAGLGAAVVALLLRAPFLVVLATAAVVTAALRHFMS
>NC_013595.1|WP_012889585.1|3136962_3138540_-|serine/threonine-protein-kinase
MTDSQGLIGARYRLLEHIGRGGMGTVWRARDEVLGRDVAVKEVIPSPDLTGPERDVFTVRTLREARAAGRIGHPGVATVYDVIEEQGRPWIVMQLVDSRTLGAVVREDGPLPPARVAQIGLEVLGALLAAHQAGVLHRDVKPDNVLLSKDGRAVLTDFGIAVLEGDSSVTRTGALIGTPAFIAPERASGGPAEFASDLWSLGVTLYMAVEGRSPFERAHPLATLSAVMHEEPAPLRFAGSLGPVVSGLLRKDPAQRMSAHDVQIHLRAIVNGTEPQPTAPIALPVPPPRAPVQAGAAVPSTDADPGVAGRGGRRRPAVAALAAAVVAVALTSGGAAWVALNSSAGSPEGPPASVSVPAKDDTPKDKTEQARLPAKKKDPTPDTSGDGSYRPSAPPSSDQPRQNRPSPSEEPTRDGSKNGSKDGSKDDSGDKPGKDQGEDQSEDSGKKPGQGSQDDSGDDTGQDPGQEQGQDDTPGQESGDDAPQDQGQGQEGQLAEQAGYNGGTSASGKTGNTSDGKVKKAKKAK
>NC_013595.1|WP_012889584.1|3136010_3136940_+|RluA-family-pseudouridine-synthase
MAEQRSLPVPDGLEGERLDAALSRLFGFSRTRAAELIVSGDVLVDGSPAAKSDRVHAGAWLDVTLPPPPTAPMPVAEPVPGMKIVYEDDDIVVVNKPIGVAAHPTTGWTGPTVIGGLLGTGHRVATSGAAERQGIVHRLDANTTGAMVVAKSEHAYSHLKRAFKERTVDKRYHALVQGHPDPLRGTVDAPIDRHPSGDGRFAVVAGGKESVTHYDTIEAFRAASLLDIKLETGRTHQIRVHMSALRHPCVGDMMYGADPTLAARLGVTRQWLHAVSLAFEHPATGEWVSFTTDYPDDLAHALKIVGSES
>NC_013595.1|WP_148269551.1|3135502_3136018_+|signal-peptidase-II
MAVLATIVPIVYILDLITKTVVLRTLEGREPLVVIPGLLQFRVIFNSGAAFSIGTGMTIVFTFVAAGVVIAILRTARHLRSLPWAITLGLMLGGALGNLTDRLLRWPSGFGRPSPFQGHVVDFIETFPGHFPVWNVADSAIVCGGILAVILAWRGYQIDGTRDTGEHKSNG
>NC_013595.1|WP_043651988.1|3134987_3135407_+|TraR/DksA-C4-type-zinc-finger-protein
MAATVRADEGAVAPSQDGTVVTWSATELAEVRKRLATEIAELNQEIAKAETEIASSDVTDGAGDDQADAGARTYEREREIALTLNSRDLVAQNERAIARIDAGTYGVCESCHKPIGKERLQAFPRATLCVACKQREERR
>NC_013595.1|WP_012889582.1|3131369_3134534_-|isoleucine--tRNA-ligase
MSAYFRSLPAQVDLPALEHEVLDRWRDGKVFERSVEQNTDGPNWVFYEGPPTANGMPGVHHVEARVFKDVFPRYKSMQGYNVPRKAGWDCHGLPVEVAVEKELGLSGKKDIEEYGVAEFNARCRESVLRHVDAFEEMTERMGYWIDLSQAYRTMDPSYVESVWWSLKVVFDKDLLFRDFRITPYCPRCGTGLSDHELGQPGGYETVSSPSVYVRMPATSGPLADLGASLLIWTTTPWTLVSNTAVAVHPDVTYVAARPAGSDEVLVVAEPLLVSALGEGAEVLASFQGADLEHTTYSRPFELVDIPGAHYVVLGYYVTTEDGTGLVHQAPAFGADDLTTCKRYGLPVVNPIGPDGRFLDSVPQVGGQFFKDADEDLTEDLRARGLLYRGGHFEHSYPHCWRCHTALLYYALPAWYIRTTAIKEQLLAENEQTNWYPETIKWGRFGEWLRNNVDWSLSRSRYWGTPLPLWVCSADESHITCVGSLEELSRLSGQDVSALDPHRPYVDDITLPCPTCGAEARRVPDVIDAWYDSGSMPFAQWGAPYQNADMLEKAYPAQFICEATDQTRGWFYSLMAVGTLVFGRSSYENVLCLGLILAEDGRKMSKHLGNVLQPIPLMDQHGADALRWYMACAGSPWAARRVGHGALEEIVRKVLLTYWNTASFFTLYANAESWSPSRLSEAPPHAERPLIDRWVLAELHRTVAEVTASMDEFDTARVGRRLAEFLDDLSNWYVRRSRRRFWSGDASAFATLYECLETVTRLMSPVVPFITDYVWDVLRATEAPSSVHLAAWPSVTEELLDPALSEQMALVRRLVELGRSARASSGVKTRQPLGRALVGARGWAALSPELRDLIADELNVQGLEDLSGIEADLVSFTVKPNFRALGKRFGSQTKLVAAAVAAADAGELARALRSGSAVAVDAGELGTVELSGEEVIVTEQPKSGWAVETGAVDTGTGETVALDLTITDELRRSGLVRDVIRLLQDARKSTGLSISDRIDVWWSTTDADLAEALRTQGGTVAGEVLAVSLSEGSGGDLPAHHDADLDLTFQLRRTV
>NC_013595.1|WP_012889581.1|3129001_3130900_+|hypothetical-protein
MILISAGLVVTAIVLLIAGFVLAKPFLVMWSIAVSVLSAVFLVIGALLRRHELFPGGRAGAAPLPPEGPVPAGPMPAPHMRPDQRVPSAPHPRAPHGMPPAATVASQPRPRPVAGPAPAARQGLLDAEAIVLVIPGRKRYHVAGCRQLAGRDHEELTHEEAREEGFTPCTTCLPEFTGGIQPQDAPIGAQKPVAHPAPSPEPGPSGDTRGPDVHEPTARFSPPYGPVTTATPQEAAAPVTRPYIQGPAAPREQARPQEPASPPLRAAETAARTFPIQSPEPEPETSADAEATSWFSRDMVASAAAQPETPAEPEPSEPSKSSAPSEPEDGTPAEPEPVTPASTGAEAPAEAGGPAEPDPTGAETSIIPSRSLPSGGSAPSEVEESAESEGGSEPRGGAPAGSRPAGAGTPVGGEAPAAPSAPAAGSPATSSAPAGAGSPVRGEAPVASSASDPASSEPSKADPEPSKADPASSESSKADPEPSGAEGTAGPGSPATSASAAQEAPEEPSPAARKAADRSASAEPDSPSEPAEPQVPAAGEKAPEAVPETAPEEASGADDGDTAPHGIPAVKDSPEPALGGSGAVKVIVGTRRFHSSACPLIKGTDGSGIETMTRAEAEEAGLSSCSVCRDQG
>NC_013595.1|WP_012889580.1|3128101_3128959_+|DivIVA-domain-containing-protein
MPLTPADVRNKQFSTTRLRPGYDEEEVDAFLDEVESELDRLIQENEELRAKLAECLRGKVPGGMGMAMAPAPVAEPKPEMMMPQPEPMRAPEPVQHQQPVPVGMGMPPAEDNMDTAARVLALAQQTADQAIADARREADETVTRARREADDILGKARRQAEQVIGDARARAETLERDAQERHRQAMGSLVQTRDELERKVEELRSFEREYRSRLKLYLENQLAELTVAAEGSGGFPIVGGPPAMSHAVAQGGQPTIQGAPNPFGGEPSQHSGAFQGVDGPHNDRR
>NC_013595.1|WP_012889579.1|3127764_3128052_+|YggT-family-protein
MGIVSEILVVILSLYLVLLIGRMIFETVQAFARQWRPTGVVLVLAEAVYTVTDPPLKFLRRFIPPLRLGTVAFDLSFTVLFIVVLVLIQLVSALR
>NC_013595.1|WP_012889590.1|3142519_3144526_-|serine/threonine-protein-kinase
MAEAQSSEGRRIAARYHLREPIGRGGMGIVWRAHDELLDREVAVKEVRYADMLGEDNQEDFNRRTKREARAAGRLTHPNVVVVHDVVEEDGRPWIVMQLVESRSLGKVLRQDGPLPPEQVAEIGLQMLDALRAAHAQGVLHRDVKPENVLMAHDGRVVLTDFGIATLETETALTMTGIAGTPAFIPPERIKGGSAQRESDLWSLGATLYAAVEGKPPHDRGGALPTMHAVLNDEPEPPVRAGRLLTTVLDGLLRKDPARRMSYDEAARLLREVADGGKQRAAKPAKTAVMPAVTTSATAETDPGIKYEPEGFPATGVQLGSAAPAPAKSPPPAAPAPREPVVEVRQEPASRPAPEPAPRPAATPASRPAPEPAPRPAPKARRDPFPPLRPEPRAEPVPAPRPEPVPPAPRDPGVRDLSSAATSAPVHGPFSTSPTAFSRGSRSPVKRGLLVLVPAVLIVGAVAGWLGMRSRESDGLQAPQANTGKPAASAGPAKTTADATPSTSPSPAPSPTKTKEKEKEESKLPDGWHMHKDSNDFSIGLPKGWKVDKRPGQQVWFRGPDRTSFVFVEYVAKAGPDPKKDWYTGERASRGSFPGYERIRIEKVDYMEKAADWEFTWNTSSGKARVLNRGFVTKGGRGYAIYWHTLAKDWKKNMHLFEGFARTFSSKK
>NC_013595.1|WP_148269552.1|3145890_3147219_-|amino-acid-permease
MIAIGGAIGVGLFLGAGGRLQAAGPALVLSYAAAGLAAFFVMRALGELVLYKPTSGSFVEYAADFVGPWAAFASGWMYWINWAFTGIAELTAISIYVSLWAPEFPRWLTALISLGFVLAVNLLSVRLFGELEFWFALLKVLAICAFLVTGLALVIFGFELGGSTAGAGNLVAHGGFFPNGFPLALMSLQSVIFAYSSIELVGIAAGETENPREVMPRAINGVIWRIVVFYVGSVLLLAMVLPWTAYGPGQSPFVTVFAALGVPWAADAMNLIVITAALSSCNSGLYSTGRILRAMAQKGEAPAFAGQLSSRQVPYGGILITATVFVAGVVLYYYVPERAFNIATAIASLGVITTWGTLLYCQIRLRRAAEQGLLERPPFRMPGSPYTGWLTLAFLALVMLLMPFADADQRIAFFCIPLLVAAIAVGWRIVDPRRRRAGVPLD
>NC_013595.1|WP_012889593.1|3147453_3150975_+|DNA-polymerase-III-subunit-alpha
MSDSFVHLHVHTEYSMLDGAARLKQMFKQVGDLGMPAIAITDHGNMHGAYDFYKQATGAGIKPVIGIEAYVAPASRHQKKPVLWGEPHQKRDDVSAGGYYTHMTIWAKNAKGLTNLMKLSSRAYTEGFVRKWARMDAETLAEHSEGLMATTGCPSGEVQTRLRLGQYDEALAAAAKFQELFGRDNYYLEIMDHGLDIERRVRDGLTRISRDLNIPPLVTNDSHYTYESDATSHDALLCIQTGKQLADPDRFRFDGSGYYIKTADEMRAVDSSDLWAEGCRNTLLVAEKVDPTGMFGFKNLMPTFPIPEGDSEESWFRKEIWKGMERRFPEGVDEEHRAQIEFEMNVILQMGFPSYFLVVADFIMWAKNNGIRVGPGRGSAAGSLAAYALGITDLDPLPHGLIFERFLNPDRVSMPDVDIDFDERRRGDVIRYVTEKYGADKVAMIATFGTIKAKAAIKDAARVLGHPYALGDKVSKAFPPAVMGKDIPLSGIFDKDHPRYNEAGELRKLYDEDVDVKSAMDLGRGLEGLIRQTGVHAAGVIMSSEVLTDYIPIMRRDSDGVIITQFDYPTCETLGLLKMDFLGLRNLTIIDDCLKMIEANTGTKIDLLKLPLDDRKTYELLGRGDTLGVFQLDGGGMRSLLRLMKPDNFEDISAVGALYRPGPMGADSHTNYALRKNGLQDITPIHPEFEESLQEILGTTHGLIVYQEQVMAIAQKVAGFSLGKADLLRRAMGKKKKSELDKQFESFEQGMKDNGYSAAAIKTLWDILLPFSDYAFNKAHSAAYGLVSYWTAYLKANYPSEYMAGLLTSVKDDKDKSALYLNECRRMGIKVLPPDVNDSDFDFTPRGTDVRFGLSAIRNVGGNVVDGIIAARREKTRFADFKDFLRKVPMVVCNKRVIESLIKAGAFDSFAHERKGLVMVHEQAVDSIIGIKKNEAQGQDSLFGAVEGAEDQTFDVQIPPGEWDKTTLLQFEREMLGLYVSDHPLFGVEHILASGADCSIAALQDENRSDGQVVTVGGILSGVQRKVTKKGDTWVLTMLEDLEGAIEVMIFPSAYQLCATVLAEDAIVFVKGRLDKREDVGKIIAMEVTAPDLTRESGGPLAVSLPLTRCTPPVVGRLKEVLTAHPGTTEVHLQVHNGPKTTIVRLDDRLRVAPSPALMGDLKQLLGPACLGA
>NC_013595.1|WP_012889594.1|3151179_3152538_+|discoidin-domain-containing-protein
MSSTTSRSVPHRLLPALAALAALLAGVLVATGRAEAAETLLSQGKPAASSSKEGSSYSSGKAVDGNLTSTRWASLEGSDPQWIRVDLGAVSPISRVKLFWEAAYGEAYRIQVSDDAATWTTVYSTSSGDGGEDDLTGLSGSGRYVRMYGTARGTEYGYSLYEFQVFGGGTSTPSPTPTVTPSVPPGDSFVVAAAGDIAAQCTASSSSCAHPKTAAQVQAMNPEFVITMGDNQYDDARLSDFQNYYDKTWGKFKSKTRPAAGNHETYDPAGTYAGYKGYFGSIATPQGKTYYSYDRGNWHFIALDSNYFDQAAQINWLKADLAATTKGCVAAYWHHPLFSSGEHGNDPVSKPVWKILYDARADLVLNGHDHHYERFAPQNPDAQAAPDGIVEILGGMGGASPYNIENVQPNSLKRLKDIYGVLKLKFGPDTFSSQLIGTDGAVKDTSPTYTCH
>NC_013595.1|WP_012889595.1|3152538_3153759_+|MFS-transporter
MYISASRAADGARPRSRLSWAVPGNVLALGAVSLVTDISSEMVTAVLPLYLTLSLGLNLLQFGLLDGLSFGVTALVRLAGGNLADRWQRRKLVAGIGYGLSALCKPALLAAGGSVAALGAVIAVDRTGKGLRTAPRDALISLSVPPDGLGQAFGVHRAMDTFGALLGPLVAFAVLMGTGGAYDAVFVVSFCVAVLGVLLMVMYVRDRRMPLPGPRSATSPRAAFGLLREAAFRRVCVVAAALGLVTLSDAFVYLLLQKRGGFGAEYFPLLPIGTAAVYLLLAVPVGRLADRVGRIPVFLAGHVALVAAYLVLIGPGWLVAVLALQGVFYAATDGVLMAVAGPMLPAHLRTSGLALLQTGQATARLFSSVLFGAVWTVWGSTQGLAAMAAGLAVCVLGAWSVVRRHA
>NC_013595.1|WP_012889596.1|3153755_3154724_+|hypothetical-protein
MTPLRRLLVLLAALAVLGGAAAGYAAWAARRDPVPAQAGQAGPGGVLRPGQLMFRTAAGRVAGVPLADTSAAPAGGGLACDRFSTGGGTSICLVARPGPVATTHAVILDRSMRETRRVKLAGIPNRARMSQSGRMASWTVFVTGDSYSEGGFSTWSGILDTRTGYAVTNIEDIPLTLNGRRYHAADVNYWGVTFAADDNRFYATVATKGKTYLVEGDYGRWQARTLRENAECPSLSPDGTRLVFKKRVSADPGRMWRLHLLDLATMRETPLAETASVDDQVAWLDGRTVMYAKGPDVWSVPADGSGAPARLVRGASSPVAVR
>NC_013595.1|WP_081453108.1|3155090_3156197_+|serine-hydrolase
MYGTYSAVRDAGADWSGAAGVADVRTKRPVHPRMLHRVGSITKTFTAVALLQQVERGRIELDAPVSRYLPELIPGERGQKITVRMLLNHTSGIGDYVSGAFPSFQQGSTASLDDNRFRDFSPGELVRFGLEAPSTGEPGQNWSYSNTNYIIAGLLLEKVTGAAAEPYITRHVIRKAGLRDTSFPRTPLIPGPHSKAYESFYGYIDPPRDYSVYDMSWAGTAGAVVSTMDDLNRFYRALLGGRLLGSAQLAQMQTTVPVTDGQGNVLMNYGLGLYAQDLPCGRFWGHDGGVFGMGTFSLSSPDGRRQLSLGINLMKYQRIDENGVLQPHAIDFALGDHMLQALCGPAAPLAKGERPLTPFPTQQVLVKR
>NC_013595.1|WP_012889598.1|3156366_3156942_-|RDD-family-protein
MTAEPPNHGAYGQAPYGSVPPAPPVLAVWWERLVARLIDSVILGVVVMVIITPIIAGAFTTTEEITLLGTTAEVPVTSFLGLLISAIVGFLIYSAYEYFQITRDGQTLGKKLMKIRITTVGAGLQGGLDSQSALKRIGVLYGPQLLGFQTFLNLIGGIFSLVNVLWQFWDKPLQQCLHDKVANTVVVKVSR
>NC_013595.1|WP_148269553.1|3157406_3158702_-|glycosyltransferase
MRGSVRRAALWSLRRLNDRRARRASATGAGGDTGTVRILLHHAYGMGGTIRTVLNLAGYLARERDVEIVSVVRTAEEPFLPIPPGVRVSFLDDRVAARGPAARLLSRFPSRLVPEQENIHHTVSLWTDLRLIRRLRAMRGGVVITTRPGYNLAAALFAPPEVITIGQEHVALQVHKPEMRRLIRRRYGRLDAFVTLTEADLEQYAGLLEADAPRRLVRVPNAVPRLAGDVSRLEEKVAVAIGRVVHAKGFDRLVKAWRQVAQAHPDWILRIYGGGTPEREQRLRDQIEEAGLTGRVLLMGSSREIGVELAKASIYVVSSRYEGFGMTILEAMSKGVPVVSFDCPHGPREIITHEHDGLLVGAGKAGALAGGIRRLIEDEELRRTLGGNALRTAARYDLDAVGARWDALLADLSGLSSRPDPQPCSLGTPVF
>NC_013595.1|WP_148269080.1|3158794_3159787_-|hypothetical-protein
MRTDHSKDRTTRPATPIRRLTAVGIGLAAVGAIALSGPQPMPALRLAAAAQAVTAPAEGAYWHTRTLWKGTYSHQLGRGKNRYWVEQQSVAERWTALDGRTWRGYRDLGVRPKSAADERAWRRDGSPTTWTRTANGMTASLSAQPDKGRLFLNLGAKGAPLIGFDLVDRMLSYEQAQALPTDPAGLKTWIDKASRDPNSGVSDDTRESYVRGQLVGILSDAPVKEVRAAAYEALPTIPGVRSLGKVEDPRGRTGQGFLIDLAWGKGSGGSQQKHVIAATERLIVDTGTMTPLASEVKYGGEPVPAKTSTSTSVTLQIGWTDGKPSVPALP

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Crispr_ID: NC_013595_24

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_24

3381930-3382136

Orphan

Consensus_repeat	Method
CGGGTCACCCGAGCCGATCACCCGG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_013595_24

>merge|NC_013595|24|3381930-3382136|CRISPRCasFinder
CGGGGCGACCGAGCGGCTCACCCGGGCGGGTCACCCGAGCCGATCACCCGGACGGGGCGACCGAGCGGATCATCGAAGTCGGATGGCCGGACGGGTCAGCCGAGCGGCTCACCCGGGCGGGTCACCCGAGCCGATCACCCGGACGGGGCGACCGAGCGGATCATCGAAGTCGGATGGCCGGACGGGTCAGCCGAGCCGATCACCCGG

>NC_013595|24|22|3381930-3382136|CRISPRCasFinder
CGGGGCGACCGAGCGGCTCACCCGG	GCGGGTCACCCGAGCCGATCACCCGGA
CGGGGCGACCGAGCGGATCATCGAA	GTCGGATGGCCGGACGGGTCAGCCGAG
CGGCTCACCCGGGCGGGTCACCCGA	GCCGATCACCCGGACGGGGCGACCGAGCGGATCATCGAAGTCGGATGGCCGGA
CGGGTCAGCCGAGCCGATCACCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012889792.1\|3380926_3381883_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012889787.1\|3375103_3375517_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350221
NC_013595.1\|WP_012889799.1\|3388599_3389376_+\|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274373
NC_013595.1\|WP_148269569.1\|3389462_3389951_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NC_013595.1\|WP_012889783.1\|3371167_3371899_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_013595.1\|WP_012889793.1\|3382141_3382759_-\|FMN-binding-negative-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377290
NC_013595.1\|WP_012889791.1\|3379569_3380655_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NC_013595.1\|WP_012889790.1\|3378566_3379493_-\|proline-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223580
NC_013595.1\|WP_148269568.1\|3388034_3388400_-\|anti-sigma-factor-antagonist	unknown	unknown	gnl\|CDD\|132914
NC_013595.1\|WP_012889789.1\|3376941_3378567_-\|L-glutamate-gamma-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143441
NC_013595.1\|WP_012889788.1\|3375634_3376660_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012889784.1\|3372474_3373119_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012889801.1\|3390016_3391342_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NC_013595.1\|WP_012889794.1\|3382868_3384047_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340830
NC_013595.1\|WP_043652056.1\|3374882_3375107_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227035
NC_013595.1\|WP_148269091.1\|3373137_3373896_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012889802.1\|3391410_3391605_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012889797.1\|3387240_3387957_+\|GAF-and-ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|198080
NC_013595.1\|WP_148269567.1\|3385253_3387101_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_013595.1\|WP_043652062.1\|3384138_3385092_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|379605

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012889789.1\|3376941_3378567_-\|L-glutamate-gamma-semialdehyde-dehydrogenase	gnl\|CDD\|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
NC_013595.1\|WP_012889787.1\|3375103_3375517_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350221	cd09873, PIN_Pae0151-like, VapC-like PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Pyrobaculum aerophilum proteins, Pae0151 and Pae2754, and homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.27115e-24
NC_013595.1\|WP_012889799.1\|3388599_3389376_+\|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274373	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. This group of similar sigma-70 factors includes clades found in Bacilli (including the sporulation factors SigF:TIGR02885 and SigG:TIGR02850 as well as SigB:TIGR02941), and the high GC gram positive bacteria (Actinobacteria) where a variable number of them are found depending on the lineage.	4.93315e-99
NC_013595.1\|WP_148269569.1\|3389462_3389951_+\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	4.65899e-16
NC_013595.1\|WP_012889783.1\|3371167_3371899_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.31325e-15
NC_013595.1\|WP_012889793.1\|3382141_3382759_-\|FMN-binding-negative-transcriptional-regulator	gnl\|CDD\|377290	pfam04299, FMN_bind_2, Putative FMN-binding domain. In Bacillus subtilis, family member PAI 2/ORF-2 was found to be essential for growth. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.	1.00152e-25
NC_013595.1\|WP_012889791.1\|3379569_3380655_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	8.10139e-18
NC_013595.1\|WP_012889790.1\|3378566_3379493_-\|proline-dehydrogenase-family-protein	gnl\|CDD\|223580	COG0506, PutA, Proline dehydrogenase [Amino acid transport and metabolism].	3.6212e-49
NC_013595.1\|WP_148269568.1\|3388034_3388400_-\|anti-sigma-factor-antagonist	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.42433e-18
NC_013595.1\|WP_148269567.1\|3385253_3387101_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.34246e-32
NC_013595.1\|WP_012889797.1\|3387240_3387957_+\|GAF-and-ANTAR-domain-containing-protein	gnl\|CDD\|198080	smart01012, ANTAR, ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	7.98501e-16
NC_013595.1\|WP_012889801.1\|3390016_3391342_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	1.09285e-99
NC_013595.1\|WP_012889794.1\|3382868_3384047_-\|glycosyltransferase	gnl\|CDD\|340830	cd03800, GT4_sucrose_synthase, sucrose-phosphate synthase and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.	1.20447e-84
NC_013595.1\|WP_043652056.1\|3374882_3375107_+\|hypothetical-protein	gnl\|CDD\|227035	COG4691, StbC, Plasmid stability protein [General function prediction only].	0.00670225
NC_013595.1\|WP_043652062.1\|3384138_3385092_-\|sensor-histidine-kinase	gnl\|CDD\|379605	pfam14417, MEDS, MEDS: MEthanogen/methylotroph, DcmR Sensory domain. MEDS is prototyped by DcmR and is likely to function with the PocR domain in certain organisms in sensing hydrocarbon derivatives. The MEDS domain occurs fused to Histidine Kinase and as stand-alone version. Sequence analysis shows that it is a catalytically inactive version of the P-loop NTPase domain of the RecA superfamily.	1.01375e-32

>NC_013595.1|WP_012889792.1|3380926_3381883_+|hypothetical-protein
MSDADPVRQALSRLVDSGQLRAEQVEPVALAVHEALRVRVADDRVRWSEIVSYVGGGLVLAGAAAFVGLGWDRMTQPARVTVLAVITVLLLVTAAWLGRLAWVATGRTAAVQRRVAATLAALGSGSAALCAGVLAESDETLAAGAAGLVVAAAAYVALPTAVGLLACGALGMVAVTGLLEAFAWPGSAAWGAGYVALGVLILGLALAGRLVPRPLALGVGAAVALFGGQWPLLWEEEVWGYSATAVIALACLALYGRERTWVLIVAGVAGLTLAVPEAVWHWTGGAVGGAVILVLAGAVLLAAAGLGVLLHRRTARGR
>NC_013595.1|WP_012889791.1|3379569_3380655_+|helix-turn-helix-domain-containing-protein
MHNNGGVLQETVDEIAARLGASATLEDRSFQLLAYAAQSGDIDEVRQESILRRRATEEVRAYFEGYGIATAPGPVRIPEDAELGVLARVCVPLRHHGVTYGYLWLLDDGTLGGDALASVSDLVARVAAVLAQETRRRQDLGRNLRELFSPDADERSWALARLNVPGPVTAIAVRSSLDRVAALWTLPRGVLADPGLLVQGESLVALLAPAGQAWELAGRVQGMYGTAAGVGDARADPAQAWRSWREAVQALNVAGKVPALAPVAAWSDLGVYRTLAHLSPADLRELAEETAGLADDPELARTVEGYLDRAGHVQAAAAALGVHRQTLYYRLGKAERLTGRDLADGEDRLLVHLSLKAARLL
>NC_013595.1|WP_012889790.1|3378566_3379493_-|proline-dehydrogenase-family-protein
MLGSLLLAGSRVPLVRRAVSGVPLTRKVVDRFVAGETTQDAVESVHRLTDAGLAVTIDHLGEETRDAEAAAQTADAYIVLLGALRELELGDRAEVSVKLSAVGQALGADGDKIALENAQHIAEAARGAGANVTFDMEDHTTVDSTLGILRAVREDFPSAGVALQAYLFRTEDDCRDLSHEGSRVRLVKGAYAEPASVAHQNKNEVDKAYVRCLRILMAGKGYPMVGTHDDRLISITETLADRFGRSLGEYEYQMLYGIRTDKQQALVGAGHTMRVYIPYGDDWYGYFMRRLAERPANIAFFLRALGGK
>NC_013595.1|WP_012889789.1|3376941_3378567_-|L-glutamate-gamma-semialdehyde-dehydrogenase
MDAIFNVPVPANEPTLGYAPGSAERATLENRVKELAGAQLDLTMTIGGEQRMGGGAPIDVVQPHNHASVLGRTADATADDVRAAIDSALKAAPAWRALSFEERAAIFLKAADLLAGPYRQTLNGATILGQSKSAQQAEIDSACELIDFLRFNVAYARQLYSDQPVSSPGVWNRMEYRPLEGFVLAITPFNFTAIAGNLPSSAALMGNVVVWKPSPTQQFAAHFTMRLLEEAGLPPGVINMVTGNGTAVSEVATTHPELAGIHFTGSTPTFQHLWSTVGANIGSYRGYPRLVGETGGKDFVLAHPSADPAALTTALVRGAFEYQGQKCSAASRAYVPRSVWSLIRDDLVGTAESLTIGDVAADLSTFMGAVIDERAFAKHKAAIDRARGLDSINVLTGSYDDSTGYFVKPTILESADPTDEIFTKEYFGPILGVHVYDDADFDSVLDQMESVSPYALTGSIIAQDRYAIASASERLRFAAGNFYINDKPTGAVVGQQPFGGARASGTNDKAGSIFNLIRWVNARTIKETFVPPTDHRYPHMG
>NC_013595.1|WP_012889788.1|3375634_3376660_+|hypothetical-protein
MIDETRHRYADFLQRNPYVAQATCWIVVQPVTAPLSVETIAERLGGRAEDLEYEPDDDVDEADYEGAFYISQDGASFVVFEDNGYQGTRPEVLRQLSDSARVVSLFWNVNANTMLHYAVYGTVVTALDPMFPGRRWGKDPHALDAELAVLDEDHGPGGWRAGAMAVVEAVTGVRLDLPDAGAPRLLLEETLPEDPHPPSTLGQVDPDLDVRLRLAPEPVQAKVVRHVVAVCVEATGLADESLVRDALDRLVTGHSAEQAAADLRPLLARLMDDRRDAEGEVLPNDHPVSCRHWAARALETALRGHRWSDRLDALVNAPTILGETWPPLRSRLKAMIAEAGG
>NC_013595.1|WP_012889787.1|3375103_3375517_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MSLVVDASIVFRLLANVKGDDLLRQRLARKVHAPALIDVEIASVVRGHVVTGKPEVRISEARAQIMLERYAQLKIVRHPMLPLQPRVLELRNNLTAYDGMYVALAELLGVPMLTDDAKFAGSTGHRTEIHRYPPPLV
>NC_013595.1|WP_043652056.1|3374882_3375107_+|hypothetical-protein
MGTMQIRDVPDATERTLKARAERDGKSLTAYVRDLLNEEAATPTLDEVMAKIAADEPVPYDPDFVREMMREGHR
>NC_013595.1|WP_148269091.1|3373137_3373896_+|hypothetical-protein
MVRRYAILALTLAAATALSACGGTGGIAAENTGQKQGQAHDVEQIGKLDVSVLRVVHSDFSAYESPEALAADRPIVAAGVIDGWQQGPILESYPNGPLDYRAVLRVRVTEPLKGVKGRESISDGLIYIELDQGGVVSDPSVPAGQWKPRKSIEDFDKALPAGTKILVFPRERPRHEMPVRSPGAPLPPEAKLMVVPPQGLVLEDPQLLQRQSGDATALVGGQERLSVGGEAWFKPKNMGELVTHLKQRGFSE
>NC_013595.1|WP_012889784.1|3372474_3373119_+|hypothetical-protein
MRIGIRVVLAAIIAIVTTTVTTITPAAADLWPFDGIPPDKSTHSYCYTTSVQADLKSYIPGAMNYLANATTIPGVPFHSPCETTNSSSDGTPATDVAWFDVWVEGSFGQAVCKVWTASDPDVCDQRHARINGNVIRASGDPHHQFIKTVCHELGHTAGIDHYSPLAAPPEPPGAFGQPQDCMASGDVTAIGNPGGSWIHTYNPHHIGDANPHWA
>NC_013595.1|WP_012889783.1|3371167_3371899_-|class-I-SAM-dependent-methyltransferase
MNPADFYTGIVAELYGPLKSVAQDPEPYAAFVQEAGSPALELGCGDGDPLLDLRRRGLDVEGVDASADMLDRCRRRAWKQGVDVDVYHQRMEALDLPRRYRAIFLAGPTFNLLPDDSTALAALHGIRNHLAVGGTALVPLFVPSPTPAEQIGRARTATADDGAELRVSVLSEERSDSARTQTTVLRYERYRDGESTIVDRPWVLHWYTRSGFEGLAAAAGLIAVSVLETPGASDLQFQLQAAD
>NC_013595.1|WP_012889793.1|3382141_3382759_-|FMN-binding-negative-transcriptional-regulator
MLIHPWDSATEDEALDFVRANEFGHLIAAGRGREVPVVVPTQFLLTGDRTILLHLARPNPIWAAIEENPAVVVSLAGDWSYVPGAWKTLPGLEDPRTGVPTTYYAAVQLVCRAEVVGDAEGKTEILRAQLARLEPDGELVDPAEHGRRLPGIRGLRLTIQEVNGKFKYGGNADERHRRHIADRLAERDGPGDAAARRHLLRRLDG
>NC_013595.1|WP_012889794.1|3382868_3384047_-|glycosyltransferase
MPISSQRCAVNIAFVSSDALSASQSQSDLAAQRAHLLAIARELGREHKVTIYTRRHSDADKPRVRMFQGVTLENLAAGPAEDLPEDSVLPYLPDLGDQLMRRWGQDRPDVIHAHSWTGGLAAIAGADGLGVPFTQSFSSEHSRDAKKVRVQRAIGRRASAVIAGCGDEESTLIRLGVPRRNISVIPCGVDVERFRRQGPAAARGTRPRLLHVGPLTQDKGVSTAIRALEGIPDAELLIAGGPDVAGLAHDADAHRVMLLAKEVGVEDRVTLLGQVPHTSVPKLMRSADLVISLPHETATGIVALEAMACGVPVIASAVGAHLDSVVDGVTGLLVPADRPAQTSRLIRELLADPTRRTALGFAGADRARSRYSWERISQELVQVYENALATQH
>NC_013595.1|WP_043652062.1|3384138_3385092_-|sensor-histidine-kinase
MTPVHQAAVYDSDQCFLAMALPFVRDGLAKGDPVMAVTTPANLELLGDALGQDGLLVDYAESGFLGRRTVERVTAFHRYWRRRGAEARGDGHVRVIAEPLWTGRAAREVRAWQRMESALNLLLSGTNVWMICPYDARVLDPEVVAAARRTHPTTSADGRTPLACSEYTDPVDFIRECDSAPVLEPPRDAASVTAATFPALREFVTGQASLLGLSPDRASLLAVAAGKVADQLELPVTVRLWERFGAITCHLHRPGGRIANPVAGFLPPGPTDRPGDGLWVARQLCDRLDIHDDLGGCTVQLHVPSARAEELRQSRKY
>NC_013595.1|WP_148269567.1|3385253_3387101_-|SpoIIE-family-protein-phosphatase
MGLQALEQALNALTTRVSSLREARSAYPADPRSTLDAALAELDTARELLEASLRELRKAPKRSGERESGSQRELKLLRQVFRTFPVPVVVLDASGVVRRISAETSQMLGSPAGYLIGRSFPLLVDVSRRAAFRSHLTAVQQGGQTATFQTRLAHQGRAHTVQLAVTRLTMPGEPQEMTAIVILPLEAQVAGAPPGPVDRSDATLIMAAARRQELLSTMTRLLLDEESLRQPVTVTRAARLLAAESSDWVIADVVRDGVPRRACVLGPSDKPVTELVRLIEGMTPLAAPAVAHVLTGGSGVVHEMLEEETLLGEVPGGPPLLRVMGAASLLIVPIQGEDGALGALTLVRLRDREPFSLADLGLMEEIGVHLGLALRARRSFQTRSQAADALRTSVVPRSLPDIPGFEAAAIYHAGSSPVGAEFYDVFPVRDGWGFALGGAAGKGEEAASVSAMVRNGLRVLSVWESDPGEALRKLNHALTAQNSGLFVMAVAGFVRARKISLASAGHHPAALLQPDGGVRFTAGGGVPLGIASEAEMFSEELTLTSGQTLVFYSDGLVASQNEQGEQYGENRLADVLARCVAQSPATVVKAVEEDRHAFSGGRVWDEIVILALRVV
>NC_013595.1|WP_012889797.1|3387240_3387957_+|GAF-and-ANTAR-domain-containing-protein
MEMVTPVLARDLAALGRVSEETSSESVLRGLTATLAGDVPGCAGGSAELWREERMVVSASHSELIVLVDSEGDLGEGPSSEARATGRHVIVQDVLRESRWPDYIGMAVRCGVRSVLAMPITVERAVLVLGLYGVRPGVFAARSVPPLADMLAEQVTVALANMWDYDEVRTDAAQMQEALAGRAIIDQAKGIIMKSSGCSAEAAFDELRRVSQHHQVKVADLARLLVDEHQRNRDGKAG
>NC_013595.1|WP_148269568.1|3388034_3388400_-|anti-sigma-factor-antagonist
MSENGERAAALTLTSALVGGITVIRVTGLLDATTRDQFADYLAAEVEEHGPDMALDLGGVTFMDSRALGLIVHHWQLSTNAGGKFALIGVEYAKTKVMWITGLAQRLPLYDTIEEALAAFG
>NC_013595.1|WP_012889799.1|3388599_3389376_+|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor
MSVQALELTDMTAEELLAEMVLPEISEYRAERLRERIVEMHRPLAMEIARRYRYRGEPLEDLLQAAYVGLMKAINGFDPTLGHAFRGYAVVTMTGEVKRHFRDRTWAIRVPRVYQERRAELNRLVADLSQDLGRAPTVAELAVKMRISEEDVLLTLDASAAYSALSLDAPLGADDDAAALGDIIPDEDDALGVLVDREAVKPLIDKLPTREKNILLLRFFGNMTQAEIAAEFGISQMHVSRILRKVLDQLREELVAEC
>NC_013595.1|WP_148269569.1|3389462_3389951_+|ATP-binding-protein
MARWDRGGGSRVNENGARPARFLASGDRSRPVPAGAAVAELAFCLPDLPDVRDFATVQAVRSGMSQEGLADFLVAVNEVATNAVTHGHATAKAVLRMWTVGRTLVVEIHDEGRWTPGASPGETPPAPYATSGMGLWVARMISSDIKFETGAAGTFITMSFKV
>NC_013595.1|WP_012889801.1|3390016_3391342_+|NAD(P)/FAD-dependent-oxidoreductase
MTAPVRILIVGGGYVGMYVALRLQRKLRRGEARITVVNIDSYMTYQPFLPEAAAGNVEARHVVVSLRRVLNKCEILNGWVVGVDPVARTADLCLHQGPGRTLEYDILVFAPGSISRTLPIPGLAESGIGFKSVEEAIHLRDHVLAQLDLAESTTDRSVRAKALSFVFVGAGYAGVEALAELEDMARDVCRYYPTVDPGDMRWLLVEATDRILPEVGPEMGRWTLEQLRGRGIDVRLGTRLNSAVDGHIVLDDGTEFDADTLVWTAGVKPNPLVHTSGLPLDDKSRVKASADLIVEGFPHVFTAGDCAAVPDLTKPGEMCAPNAQNAVRQARTLADNVVATLRGRARRPYRHAYAGSVATLGLHKGVAQIYGRKLRGLPAWFMHRTYHLSRIPTVNKKVRVLTDWTLGLFFKRETVSLGAISDPRQEFELAIRTEARVPSSR
>NC_013595.1|WP_012889802.1|3391410_3391605_-|hypothetical-protein
MLAIAAAVVFGLGLLLDLINTRIGGITGTTFLLLGLLLLALHQAGVGTAGVRSGGGGGNWRRRR

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Crispr_ID: NC_013595_25

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_25

3754776-3754876

Orphan

Consensus_repeat	Method
CACCCGCACGGTGTTGTCGGCCGCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_25

>merge|NC_013595|25|3754776-3754876|CRISPRCasFinder
CACCCGCACGGTGTTGTCGGCCGCCTGCGCGGGCTCGCGGTCCTGTCCCGCGTCCCGCGCCTTCCCGGGCTTCTCCACCCGCACGGTGTTGTCGGCCGCCT

>NC_013595|25|23|3754776-3754876|CRISPRCasFinder
CACCCGCACGGTGTTGTCGGCCGCCT	GCGCGGGCTCGCGGTCCTGTCCCGCGTCCCGCGCCTTCCCGGGCTTCTC
CACCCGCACGGTGTTGTCGGCCGCCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012890093.1\|3749563_3750925_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|365859
NC_013595.1\|WP_012890097.1\|3756869_3757736_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_013595.1\|WP_012890096.1\|3755185_3756247_-\|neutral-zinc-metallopeptidase	unknown	unknown	gnl\|CDD\|282131
NC_013595.1\|WP_012890104.1\|3764418_3765093_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_013595.1\|WP_148269102.1\|3760176_3761691_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|379134
NC_013595.1\|WP_012890098.1\|3757826_3758660_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|273657
NC_013595.1\|WP_012890099.1\|3758771_3760190_-\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223154
NC_013595.1\|WP_012890105.1\|3765250_3766396_+\|outer-membrane-lipoprotein-carrier-protein-LolA	unknown	unknown	gnl\|CDD\|225390
NC_013595.1\|WP_012890084.1\|3742988_3743603_+\|30S-ribosomal-protein-S4	unknown	unknown	gnl\|CDD\|235411
NC_013595.1\|WP_012890087.1\|3745376_3746045_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NC_013595.1\|WP_012890088.1\|3746121_3746862_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NC_013595.1\|WP_012890103.1\|3763034_3764429_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|273593
NC_013595.1\|WP_043652159.1\|3747852_3749208_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|379519
NC_013595.1\|WP_148269592.1\|3744812_3745211_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|211538
NC_013595.1\|WP_012890094.1\|3751096_3753142_+\|spermidine-synthase	unknown	unknown	gnl\|CDD\|223498
NC_013595.1\|WP_012890085.1\|3743826_3744699_-\|ion-transporter	unknown	unknown	gnl\|CDD\|366146
NC_013595.1\|WP_012890090.1\|3747619_3747853_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043655827.1\|3766752_3767730_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_013595.1\|WP_012890102.1\|3762327_3762975_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013595.1\|WP_148269593.1\|3746864_3747590_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|130314

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012890093.1\|3749563_3750925_-\|S8-family-serine-peptidase	gnl\|CDD\|365859	pfam00082, Peptidase_S8, Subtilase family. Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see pfam00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567.	1.84463e-23
NC_013595.1\|WP_012890097.1\|3756869_3757736_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	5.02301e-36
NC_013595.1\|WP_012890096.1\|3755185_3756247_-\|neutral-zinc-metallopeptidase	gnl\|CDD\|282131	pfam04228, Zn_peptidase, Putative neutral zinc metallopeptidase. Members of this family have a predicted zinc binding motif characteristic of neutral zinc metallopeptidases (Prosite:PDOC00129).	3.67008e-19
NC_013595.1\|WP_012890104.1\|3764418_3765093_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.91615e-85
NC_013595.1\|WP_148269102.1\|3760176_3761691_-\|MFS-transporter	gnl\|CDD\|379134	pfam13347, MFS_2, MFS/sugar transport protein. This family is part of the major facilitator superfamily of membrane transport proteins.	2.67876e-70
NC_013595.1\|WP_012890098.1\|3757826_3758660_+\|dihydropteroate-synthase	gnl\|CDD\|273657	TIGR01496, Dihydropteroate_synthase, dihydropteroate synthase. This model represents dihydropteroate synthase, the enzyme that catalyzes the second to last step in folic acid biosynthesis. The gene is usually designated folP (folic acid biosynthsis) or sul (sulfanilamide resistance). This model represents one branch of the family of pterin-binding enzymes (pfam00809) and of a cluster of dihydropteroate synthase and related enzymes (COG0294). Other members of pfam00809 and COG0294 are represented by model TIGR00284. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid].	3.35636e-86
NC_013595.1\|WP_012890099.1\|3758771_3760190_-\|aspartate-aminotransferase-family-protein	gnl\|CDD\|223154	COG0076, GadB, Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism].	3.72041e-98
NC_013595.1\|WP_012890105.1\|3765250_3766396_+\|outer-membrane-lipoprotein-carrier-protein-LolA	gnl\|CDD\|225390	COG2834, LolA, Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane].	6.5564e-12
NC_013595.1\|WP_012890084.1\|3742988_3743603_+\|30S-ribosomal-protein-S4	gnl\|CDD\|235411	PRK05327, rpsD, 30S ribosomal protein S4; Validated.	1.56861e-102
NC_013595.1\|WP_012890087.1\|3745376_3746045_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	3.02487e-15
NC_013595.1\|WP_012890088.1\|3746121_3746862_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.08793e-99
NC_013595.1\|WP_012890103.1\|3763034_3764429_-\|HAMP-domain-containing-protein	gnl\|CDD\|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	8.04506e-51
NC_013595.1\|WP_043652159.1\|3747852_3749208_-\|HNH-endonuclease	gnl\|CDD\|379519	pfam14239, RRXRR, RRXRR protein. This domain is found in bacteria, eukaryotes and viruses, and is approximately 180 amino acids in length. It contains a conserved RRXRR motif. It is often found in association with pfam01844.	1.50175e-86
NC_013595.1\|WP_148269592.1\|3744812_3745211_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|211538	TIGR00026, Hypothetical_protein_Rv1261c/MT1299/Mb1292c., deazaflavin-dependent oxidoreductase, nitroreductase family. This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity].	1.15349e-26
NC_013595.1\|WP_012890094.1\|3751096_3753142_+\|spermidine-synthase	gnl\|CDD\|223498	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism].	2.53734e-12
NC_013595.1\|WP_012890085.1\|3743826_3744699_-\|ion-transporter	gnl\|CDD\|366146	pfam00520, Ion_trans, Ion transport protein. This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.	1.42182e-42
NC_013595.1\|WP_043655827.1\|3766752_3767730_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.50747e-90
NC_013595.1\|WP_012890102.1\|3762327_3762975_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.50144e-11
NC_013595.1\|WP_148269593.1\|3746864_3747590_+\|ABC-transporter-permease	gnl\|CDD\|130314	TIGR01247, drrB, daunorubicin resistance ABC transporter membrane protein. This model describes daunorubicin resistance ABC transporter, membrane associated protein in bacteria and archaea. The protein associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	1.55399e-21

>NC_013595.1|WP_012890094.1|3751096_3753142_+|spermidine-synthase
MTAAAETTPPPYPDAPSTHWLSTRPRLIVASAFMLFLELALIRWTGSNIVHLSYFTNFVLLGSFLGIGLGFLRVGRTARQPYYSPITLAVLVLVILFFPVTVDRQTEGVLYWTSLGTSGPPPWLILPVIFVAAAVVLMGPAELVGRCFPELDRLEAYRYDLVGSLTGIALFTALSFLSAPPVVWGTIAAAAYLVLLWPRTALGRLVLAVPALVVVGALAVETLTAGALWSPYYKVTYKRLDYGGVPVMDIQVNGIPHQQAVPARNRLEWERQYALPYERAAAQKLDDVLIVGAGSGTDVAIALSKGAKHVDAVEIDPKLRELGGTYHPDRPYADPRVTTVVTDGRAFLERTSGKYDLILFALPDSLTLVSGASSLRLESYLFTQQAMEAARDHLKPGGTFSMYNYYRESWLVDRLAATMQAAFGHKPCVDIVSETGQQAVITAGLSAQTQSCGAEWAGATALTPPPTGDDRPFLYLKDRTIPQIYLITLGLILLVSVFAVRAVAGPYTRMRPYADLFLLGVAFLLLETKSVTGFALLFGTTWVVNAIVFAGVLVAVLAAVEVTRRFRTPPVPVMYGVLLGGLVLAWLVPNSWLLGLPLPLRAVVAVVVAFLPIFAANVVFAKRFADSSDGTTAFGANLLGAMVGGCLEYLALVIGYQALLIVAGLLYLGAFALLPRSTRAA
>NC_013595.1|WP_012890093.1|3749563_3750925_-|S8-family-serine-peptidase
MRVLIQLRPSPDVVAAVADPDVTATTADVADGLPGVVLDPSFTPVAVPRPVPAAADGDPLSLNQSLTFSLAAGDASVMVRGEISDDELSTRVTLLPTLRNDVVGVFADPVIESNLTCGGDAPVGDWHDVERLLHVAELHAEGLDGSGVALAVLDTGINAAHVARHLGRDLLLDKERSWNPDGVTGRPGEFEVDHGTMCAFDTLIAAPRATLIDIPVLLSRRPGGSALDGLLSDAVAAFAHLRTVLEAQPAETRSLVVSNSWGSFSPRWDFPVGHPGNYSDNPAHPFNLIVASLEQAGADVLFAAGNCGRDCRDGRCAYPNRPIAGANSHPGVLSIGGVDTGGQRVGYSSQGPGRLTLRKPDICSYTHFSGSKAFGAGEPDSGTSAACPVAAGLVAAIRTRWPVSALSPAQLRTLLRRTADDRSDIGFDYDYGYGVTDTPGVLASLRRRAMRVA
>NC_013595.1|WP_043652159.1|3747852_3749208_-|HNH-endonuclease
MFVLDTHGHPLDPCHPARARRLLAAGRAVVVRHTPFVIRLKDRTVAGSTMQGVELGIDPGSKHTGIAAFSERGGSRIGLYALQLDHRGGQIRDKLASRAALRRGRRSRNLRYRAPRFNNRTRPQGWIAPSLRHRVDGTVSWVSRLSRWAPVTAVHVERVAFDTHLLSAGRPLEGVEYRYGTLHGYEVREYLLAKWGRACAYCGASGVPLNLDHIHPRSRGGSNRISNLCVACVGCNQAKNATPIEEFLTDRPVVLVKILQQSKAPLRDAAAVNATRWALWRALTATGLPVATASGGRTKWNRSRTGAAKSHTLDALHVGALDHVTGWPSMVLVIAATGRGTYARTRADRYGFPRLALPRTKQHHGFQTGDLVRAVVPTGKKAGVHTGRVAVRSTGNFNIRTRHGSVRGISHRHVRLLQRADGYGYTTHPEARNRAAFPPPPEGGGIHAGGN
>NC_013595.1|WP_012890090.1|3747619_3747853_-|hypothetical-protein
MKLVTVRLPPQATLAQAVRRLGLTEEEVDTGYGLVLIDPGQGLYGLRVAEEAARRIDPAAGGGPYADPRIEPYGPPD
>NC_013595.1|WP_148269593.1|3746864_3747590_+|ABC-transporter-permease
MLRDTWLIFRHHVRISLRQKAGIVFGVLQPLLYLVLFGPLFATIGTWETLIPGLLVQVGLLSAGMAGFGVVFDARSGVLERLRVTPAHRVALLLGRVLGSSVTLLIQSVALILVGYAFGMRAAVPGVLAGLVLMALLGVSLAALSNAIALTMNPDLFAPVMSTGIVPLVLLSGAFLPMSMAPGWLDALSRLTPFRYVLEALRELFGGHYSTWTVAVGVAVTLVLSVTCVAVGTRVFNRENA
>NC_013595.1|WP_012890088.1|3746121_3746862_+|ATP-binding-cassette-domain-containing-protein
MIKTSDLSKSFPGGVEAVRGVDLAVEAGEIVGFLGPNGAGKTTTMRMLTTLLRPTGGTATVAGHDLLADPEGVRRRIGYVSQNGGLSPADPVGEALELHAMLYGMRPAEARERVREVLDDLDLTGLETRPGGALSGGQRRRFDLGFGLVHGPSLLFLDEPTTGLDPQSRANLWDHVRRLREERGLTVFLTTHYLDEADALADRLFVIDHGVIVAEGTPAELKGGSGTLDDVFLSITGRSLREEPAR
>NC_013595.1|WP_012890087.1|3745376_3746045_-|TetR-family-transcriptional-regulator
MSEGLRERKKRETRLRISDVATGLFMARGFDSVTVAEVARAADVSVNTVFNYFPAKEDLLFDRQGEVVELLGKVMRERRPGEGAAEALRRDFLDALDTGHWRYGIHEGGDAFHRMVGASPALVARLREMDDLRTDSLARTLADETGADPGDLTPALVAGQICATLHTLTAYAVRRMLAGESVAAITPDLREQAGHAFRLLESGIGGYCVRREETPRPAGPWS
>NC_013595.1|WP_148269592.1|3744812_3745211_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MDRAVHRLSRGRTVMSDRMIPTLVLTTVGAKSGELREAPLACLPEDGGGFLVVGSNFGRAHHPGWSGNLLRTPEATVSFRGREIPVTGHLLSGRERAEAWPRLLRVWPVYDRYSEKSGRELRVFRLSPRPRP
>NC_013595.1|WP_012890085.1|3743826_3744699_-|ion-transporter
MRERVRAALEAPRFQRVIIAVIVINAATLGLETSATAVERYGTALTVVDHLALYIFVLELAAKMYVYRRGFFRDPWNLFDIMIVTVSLLPTAGGLSVLRALRILRALRLISVVPSLRRVVTALLTAVPGMTSIVVLLGLVLYVTAVMGTKLYRATAPEYFGDLPTSLFTLFQMMTGDAWSDITREVMDEHPSAWVFFVLFMLVCTFVVLNLFIAVVVSAMEDEHAEESVQATQDLGVAVLTELAALRAEVRELRERVPVPAGAGAMSGDRSPAAPAPRRRGSARGRTGGR
>NC_013595.1|WP_012890084.1|3742988_3743603_+|30S-ribosomal-protein-S4
MRYTGPKVRLSRRAGVPLTRKAVRYFEERPYPPGEHGRKTNRRQTGDYGLRLMEKQKLRWYYDVSERQMRRYWDMALRSTGRSGAELVVLLESRLASLVLRAGLAPSIYAARQYVTHGHITVDGRKVDIPSYLVKPGQVIAVRQRSRAMQPFVAAAEGTYADDRIAPYLSVDHADLRFTVVGRPAREQIVVPVDEQLVVEFYSR
>NC_013595.1|WP_012890096.1|3755185_3756247_-|neutral-zinc-metallopeptidase
MPYGQPPPPDPRHRQPPYPPPQWQPQRPRSGGGAGVIIGGVFGVVALVFVGLVVVGALIKGSRTADPVSPVAIPTFTPFEPPASSTASPEATQSRPTESTVTTPARRRILNTTLKNNTLYRAGGLPRVNCPVGSPSIYSHSQLKALILKTSKCLDRGWSQIMRAQGMTWHPPGYAVTSSRGRGACGDFPSPGSIVPYYCPRNTTIYASTTAMAKGSGNSGGYGQITDWHGGVISMMAHEYGHHVQQLSGLSNDWWQQTTRSTSRSGKLALSRRFELQATCFGAMFMRSVSASYPVTPARRNTLYYFYSRVGDWPGYPRDHGSPANNNRWFRQGYEKNKTFQCNTWLAPASSTS
>NC_013595.1|WP_012890097.1|3756869_3757736_+|LysR-family-transcriptional-regulator
MNLQQLRYVVATAEHRTMTDAARSLYIAQPALSRAIRDLERELGMTLFARSGRGVVVTAQGRRVVKLAKEALDAVREIEALSSHGHSEAELRIASTPSLEPGLAGRLLPAYSAEHPGVRVHIVRCDGRDGVVNAIRDQRADLGLTDLPVPADLVSHPLERQEIVLISPPGMDLPNPVPMSRLNGMRLVLPIPGSARRREFDALFAKYGVTPVPTVQLDERGNWLNTVRSGAASLLWYRGMAEQATRAGLVVRPLDPSVRRVIAIVHARRRLPAIAQEFLSVAEGGSAA
>NC_013595.1|WP_012890098.1|3757826_3758660_+|dihydropteroate-synthase
MTILRLRGREFRPGEFAIMAVVNRTPDSFFDRGRTYGFAAALEAVDGAVDGGADIVDIGGVKAGPGDEVDPAEEIRRVADLVAAVRERHPQLIISVDTWRAEVGEVVAEAGADLLNDTWGGVDPALAEVAAKHGIGLVCAHAGRVVPRTRPHRIAYADVVADVIAYTTDLAERAVAAGVRRESILIDPAHDFGKNTWHSLEVSRRLHEMVATGWPVLVAVSNKDFVGETLGGLPVDERHAGTMATLAVSAWQGARVFRVHDAASARTALATIAELRR
>NC_013595.1|WP_012890099.1|3758771_3760190_-|aspartate-aminotransferase-family-protein
MSLPEKGRDIEELLAEISRLKQDDLPVRGGKVTAYVYDTGRPEVHEAAARAYFEMLEVNTLDPTAFPSVVEMEKQVVGAVAELLGGGSGIFTSGGTESIMLAVKAARDARPVGGRPRMAVPVTAHPAFHKAAHYLGVAVDAVPVDPVTFRASAAAVEAAMTEDTVLVVASAPSYPQGVVDPVAEIAAVASARGVLCHVDACVGGWLLPWLREAGAQVPQFDLSVPGVTSLSCDLHKFGYSPKGASVVLFADPALRRKAYFASASWPGYTVINATVQSSKSAGPLGGAWATFQALGRDGYLELGRATLAAARRLREGIAGIPGLRVLGDPESALVAFGSDEVNVFVLSDEARKRGWFLQPQLSYAGIPANIHITVTGVTLRGVEAMLEVIAESAEAARERGPAALPDGLVDLVASLDLDALDDAAFGELAAAVGVDLGGSGQPEMAVVNAVLDALPADRREAVLIRFLSVIYA
>NC_013595.1|WP_148269102.1|3760176_3761691_-|MFS-transporter
MRERLLPERGARRARQSPAHGRPRGPAQVPRPPSPDDPPHRRLPRRPSLTLEHSPSRPLAAAPPLNRGRLLGYALGSVGTGIFSAVPGLLLLFYLTDVLGVSAAVAGAVLVAPKAWDVLLNPVVGAVSDREAVRTGRRTRLLSLGSLALPVAFAAMFAVPGQTPGVVWAGGAFLLAASAFACFQVPYVALPAEMADGTAERTRIMSWRIVCLTLGILVAGGLAPEIVGLGGGGRAGYAVMGVAVGAVMAAALLAATLSTRWVVSRPGPRQLGLVAAFRTARGNRPFFALLAAFVTQSLGVAVMLAGAPYVAVYRLGDYGLTSLMFVCMVGPSALAVPLWTRAARRFGMVACYLVAVAGFAAAALALIPVAGSAGVAGTLLLTGLIGVCYAALQLLPLSLLPETVHADAARTGHAQSGAFTGLWTAGETAGMAVGPGLFALVLAASSFASGSFDAPAVQPGSALTGLLLGFTALPAALMLLSLPLVIAYHRLARAVSPKEIHEPA
>NC_013595.1|WP_012890102.1|3762327_3762975_-|TetR/AcrR-family-transcriptional-regulator
MTSADSGQRELILRVATRLFAALGYDATSISQIAEAAGLDVATITQQAGGKRELYLAVMERAHHAELVGLERSVGEIAAASPGETSAAVHHLIDDYIDFCAQNSEFPALWMHRWLFDASDVTELDRQYVQPLVQYIIEAIAPLTRGSPDMKYVIWSVIWCTHAFSRGGVLDDEGNRVGPEDPETLRRFRAYLHEMVHCVLALPGDLPGNPPGGAT
>NC_013595.1|WP_012890103.1|3763034_3764429_-|HAMP-domain-containing-protein
MAADPRPLERVRRGRRTVGWWRRKSLRFRLTAVASVALGAALVLSAYVMISVLGRSLLATIDDSIYQRARDTVSLADAERLPDELTSPDGTLLQVVDATGRITHATTGTDRLVPLLNAGARAAAIGKGQARFLGGEPYGIPHVLRVRVLSADRGLTVIAARPFSEVQTSITTAGHVLGVGTPLLLVLLGGASWVIIGRTLRPIAALRRGAEEITDTARSRRLPVPEARDEVHSLAVTLNDMLARLEKADTRQRALVSDAAHELRSPLASIRLQLEVALGHPHGQDWQETAEGVLEDTMRLARLAEDLLALARLDERGGAPARREPVELDQLVPQTVERYGEAVTVKIGDGAIVVAGAALDLGRVLVNLVDNALRHTDSPVAVELRAEGADAVLTVTDDGPGIPEPDRERVFDRFTRLDSARSRDEGGAGLGLAIVRETVHAHGGAVHLEDACPGLRAVVRLPLS
>NC_013595.1|WP_012890104.1|3764418_3765093_-|response-regulator-transcription-factor
MRVLVVEDERRMAAALQRGLQAEGFAVDLAHDGEDGLHLARQGDYDVVVLDIMLPRLSGYNVCKQLRAEENWVPILMLSAKDGEYDMADGLDLGADDYLTKPFSYVVLVARLRALLRRGANRRPSVLRAGDLSLDPARRRVSRGETPVELTPREFALLEYLMRRHDEVVSKTEILEHVWDTFDTDPNVVEVYVGYLRRKIDVPFSRTALQTVRGAGYRLAGDGG
>NC_013595.1|WP_012890105.1|3765250_3766396_+|outer-membrane-lipoprotein-carrier-protein-LolA
MSEQTRRGRAVRWGVPIATIALVAGAIGAGPVIAAVQGDPVLPERTAAQLLADAVQATESGLKPMSGTVMQTASLGLPGLPEVAGMGGTSPAALLAGSHELKVWYGGEDRFRFALPGRMSETDLIVNGDQAWLWESATNKATRIKGAGQAGPEHDRALPAATTPQQVADEMLKRADAATAVSVSNTEKVAGRSAYQLVLTPRDGSSLVKEVKLALDGETFVPLRVQVYAKSAAEPAFEVGFTSVTFTPPAPDNFTFTPPAGAKVEEKSLADLGRRPEAGQERAEALKGEITTVGEGWTTVAVLPFSAQDLAGPAQQGGRSGGQDTTAVADALLKSAKQVSGAWGSGKVIQTKLVSALLTDDGRLLVGAVTPEKLTEAAGQR
>NC_013595.1|WP_043655827.1|3766752_3767730_+|ABC-transporter-ATP-binding-protein
MPAVRERTPSATLPAEDCSIVTRGLTKRFRSGQVAVDALDLAVPRGSVFGFLGPNGSGKTTTIRMLLGLAAPTEGTWELLGTPMPGGMASVLSRVGALVEGPAFYPYLSGEANLRRYDAADPAADPRTASARIGLALDRVGLAAAARKRYRAYSLGMRQRLAIAAALLGPRELLILDEPTNGLDPQGTREVRGLIKEIAAGGTTVFVSSHLLAEVEQMCSHIAVMRTGRLVAQGPIAGLRAGEAVRIRVETPDLAGAAAVLAASGLAQVRTGDGEVSAELGAAAPERICAELVAGGVAVRGLAVQRPSLEDVFVGLTGEGFDVNG

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Crispr_ID: NC_013595_26

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_26

4140943-4141033

Orphan

Consensus_repeat	Method
GAGCTCCGGGGGAGCGGTCAGCGCGGCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_26

>merge|NC_013595|26|4140943-4141033|CRISPRCasFinder
GAGCTCCGGGGGAGCGGTCAGCGCGGCCGCGGGCTTGGCGGTCGGAGGCGACGAGCTCGCTGAGCTCCGGGGGAGCGGTCAGCGCAGCCGC

>NC_013595|26|24|4140943-4141033|CRISPRCasFinder
GAGCTCCGGGGGAGCGGTCAGCGCGGCCGC	GGGCTTGGCGGTCGGAGGCGACGAGCTCGCT
GAGCTCCGGGGGAGCGGTCAGCGCAGCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_043652269.1\|4124644_4127341_-\|beta-glucosidase	unknown	unknown	gnl\|CDD\|224389
NC_013595.1\|WP_012890405.1\|4150381_4152157_+\|SelB-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|225815
NC_013595.1\|WP_012890392.1\|4133244_4134300_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274646
NC_013595.1\|WP_012890400.1\|4144769_4146263_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NC_013595.1\|WP_043652272.1\|4135821_4136382_+\|dehydrogenase	unknown	unknown	gnl\|CDD\|239153
NC_013595.1\|WP_012890393.1\|4134375_4135569_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NC_013595.1\|WP_174435293.1\|4143715_4144084_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240033
NC_013595.1\|WP_012890391.1\|4132656_4133079_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012890407.1\|4153869_4155960_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	unknown	unknown	gnl\|CDD\|224446
NC_013595.1\|WP_012890389.1\|4127542_4128892_-\|DUF1996-domain-containing-protein	unknown	unknown	gnl\|CDD\|370451
NC_013595.1\|WP_012890406.1\|4152514_4153741_+\|formaldehyde-dehydrogenase,-glutathione-independent	unknown	unknown	gnl\|CDD\|274314
NC_013595.1\|WP_012890403.1\|4148660_4148948_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NC_013595.1\|WP_012890396.1\|4139886_4140867_+\|polysulfide-reductase-NrfD	unknown	unknown	gnl\|CDD\|309148
NC_013595.1\|WP_012890402.1\|4147816_4148155_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012890395.1\|4139005_4139872_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|319882
NC_013595.1\|WP_012890404.1\|4149092_4150382_+\|L-seryl-tRNA(Sec)-selenium-transferase	unknown	unknown	gnl\|CDD\|235278
NC_013595.1\|WP_052317196.1\|4129269_4132236_-\|discoidin-domain-containing-protein	unknown	unknown	gnl\|CDD\|185691
NC_013595.1\|WP_012890398.1\|4142703_4143579_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137
NC_013595.1\|WP_052316968.1\|4136403_4139013_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|273689
NC_013595.1\|WP_012890401.1\|4147074_4147650_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|379266

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_043652269.1\|4124644_4127341_-\|beta-glucosidase	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	6.13147e-55
NC_013595.1\|WP_012890405.1\|4150381_4152157_+\|SelB-C-terminal-domain-containing-protein	gnl\|CDD\|225815	COG3276, SelB, Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis].	3.82197e-77
NC_013595.1\|WP_012890392.1\|4133244_4134300_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	7.68597e-170
NC_013595.1\|WP_012890400.1\|4144769_4146263_-\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	3.81111e-71
NC_013595.1\|WP_043652272.1\|4135821_4136382_+\|dehydrogenase	gnl\|CDD\|239153	cd02752, MopB_Formate-Dh-Na-like, Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the major electron donor to the nitrate respiratory chain. Also included in this CD is the Desulfovibrio gigas tungsten formate dehydrogenase, DgW-FDH. In contrast to Fdh-N, which is a functional heterotrimer, DgW-FDH is a heterodimer. The DgW-FDH complex is composed of a large subunit carrying the W active site and one [4Fe-4S] center, and a small subunit that harbors a series of three [4Fe-4S] clusters as well as a putative vacant binding site for a fourth cluster. The smaller subunit is not included in this alignment. Members of the MopB_Formate-Dh-Na-like CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	9.00431e-48
NC_013595.1\|WP_012890393.1\|4134375_4135569_-\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	2.96175e-58
NC_013595.1\|WP_174435293.1\|4143715_4144084_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240033	cd04677, Nudix_Hydrolase_18, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	2.78838e-26
NC_013595.1\|WP_012890407.1\|4153869_4155960_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	0
NC_013595.1\|WP_012890389.1\|4127542_4128892_-\|DUF1996-domain-containing-protein	gnl\|CDD\|370451	pfam09362, DUF1996, Domain of unknown function (DUF1996). This family of proteins are functionally uncharacterized.	3.81186e-57
NC_013595.1\|WP_012890406.1\|4152514_4153741_+\|formaldehyde-dehydrogenase,-glutathione-independent	gnl\|CDD\|274314	TIGR02819, formaldehyde_dehydrogenase_glutathione-independent, formaldehyde dehydrogenase, glutathione-independent. Members of this family represent a distinct clade within the larger family of zinc-dependent dehydrogenases of medium chain alcohols, a family that also includes the so-called glutathione-dependent formaldehyde dehydrogenase. Members of this protein family have a tightly bound NAD that can act as a true cofactor, rather than a cosubstrate in dehydrogenase reactions, in dismutase reactions for some aldehydes. The name given to this family, however, is formaldehyde dehydrogenase, glutathione-independent. [Central intermediary metabolism, One-carbon metabolism].	0
NC_013595.1\|WP_012890403.1\|4148660_4148948_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.26861e-10
NC_013595.1\|WP_012890396.1\|4139886_4140867_+\|polysulfide-reductase-NrfD	gnl\|CDD\|309148	pfam03916, NrfD, Polysulphide reductase, NrfD. NrfD is an integral transmembrane protein with loops in both the periplasm and the cytoplasm. NrfD is thought to participate in the transfer of electrons, from the quinone pool into the terminal components of the Nrf pathway.	1.57497e-08
NC_013595.1\|WP_012890395.1\|4139005_4139872_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|319882	cd10560, FDH-O_like, beta subunit of formate dehydrogenase O (FDH-O) and similar proteins. This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.	3.43798e-134
NC_013595.1\|WP_012890404.1\|4149092_4150382_+\|L-seryl-tRNA(Sec)-selenium-transferase	gnl\|CDD\|235278	PRK04311, PRK04311, selenocysteine synthase; Provisional.	0
NC_013595.1\|WP_052317196.1\|4129269_4132236_-\|discoidin-domain-containing-protein	gnl\|CDD\|185691	cd02182, GH16_Strep_laminarinase_like, Streptomyces laminarinase-like, member of glycosyl hydrolase family 16. Proteins similar to Streptomyces sioyaensis beta-1,3-glucanase (laminarinase) present in Actinomycetales as well as Peziomycotina. Laminarinases belong to glycosyl hydrolase family 16 and hydrolyze the glycosidic bond of the 1,3-beta-linked glucan, a major component of fungal and plant cell walls and the structural and storage polysaccharides (laminarin) of marine macro-algae. Members of the GH16 family have a conserved jelly roll fold with an active site channel.	1.07177e-109
NC_013595.1\|WP_012890398.1\|4142703_4143579_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	1.26432e-22
NC_013595.1\|WP_052316968.1\|4136403_4139013_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|273689	TIGR01553, Formate_dehydrogenase_major_subunit, formate dehydrogenase-N alpha subunit. This model describes a subset of formate dehydrogenase alpha chains found mainly in proteobacteria but also in Aquifex. The alpha chain contains domains for molybdopterin dinucleotide binding and molybdopterin oxidoreductase (pfam01568 and pfam00384, respectively). The holo-enzyme also contains beta and gamma subunits of 32 and 20 kDa. The enzyme catalyzes the oxidation of formate (produced from pyruvate during anaerobic growth) to carbon dioxide with the concomitant release of two electrons and two protons. The electrons are utilized mainly in the nitrate respiration by nitrate reductase. In E. coli and Salmonella, there are two forms of the formate dehydrogenase, one induced by nitrate which is strictly anaerobic (fdn), and one incuced during the transition from aerobic to anaerobic growth (fdo). This subunit is one of only three proteins in E. coli which contain selenocysteine. This model is well-defined, with a large, unpopulated trusted/noise gap. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport].	0
NC_013595.1\|WP_012890401.1\|4147074_4147650_+\|DoxX-family-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	1.61608e-12

>NC_013595.1|WP_012890396.1|4139886_4140867_+|polysulfide-reductase-NrfD
MVPEAEFRSYYGQPVIKSPVWHEPHMPAYLYLGGLSGAAAVMGVMAGLSGRDRLALTSRVTAALGATAGAAFLVAELGRPERFLNMLRVFKPTSPMSMGSWILAVHSGLTAAAAAPALLATRPASGIAGSLPSAVTAALPVAGDAATLASGVTGPLMATYTAVLLADTAVPAWHEAHRELPFLFAGSALAAAGAAGMLATPRAEAGPARAVAVLGAALETAAGAVLESRLGLVGEPYHQGRAGRLLRAARVLTAGGGLLAAVAGRGRVLTALSGLALTAGSLVTRFGILEAGRASAADPKYTVVPQRRRLEGEGRTPARPPARMWP
>NC_013595.1|WP_012890395.1|4139005_4139872_+|4Fe-4S-dicluster-domain-containing-protein
MTERMGFFTDTSVCIGCKACEVACKEWNDIPDDGFVFRATSYDNTGSLGASTWRHVAFIEERSRVPADPGRDGDGESGGIEGWLMSSDVCKHCTHAACLDVCPTGALFRTEFGTVVVQADVCNGCGYCVPACPYGVIDRRERDGRAFKCTMCYDRQLGGLEPACAKACPTDSIQFGPLEELRARAEERVERLHGEGRAEARLYGDSPDDGVGGAAAFFLLLAEPEVYGLPPDPVVTTRDLPAMWRWAGGAALSLVGAVAVSFLSGRVLPGEGATGRTGARGRRGGWWR
>NC_013595.1|WP_052316968.1|4136403_4139013_+|molybdopterin-dependent-oxidoreductase
MGTSFGRGGATDFQQDLVESDCIVIQGSNMAECHPVGFQWVVEARARGAKVFHVDPRYTRTSALADKHVPIRAGSDIVLLGALVNHVLVNELDFREYVLAYTNASTIISEHFRDTEDLDGLFSGFDAEHRKYDPSSWAYEGAREEAAAGLRSEQLEGGKEHAEVAGAEEYGSGGAAMLGRPRTDPTLTHPRCVYQILKRHFARYTPDLVAELCGISREDFAELADAITANSGRERTTAWAYAVGWTQHSVGVQYIRTAAILQLLLGNMGRPGGGIMALRGHASIQGSTDIPTLFNILPGYLPMPHAHRHQRLDDYLAEAGADTGFWGRKRSYMVSLLKAWWGEAATEENDFCFGHLPRLTGDHGHYTTVMAQIEGTVKGYFVVGENPAVGSSGGRAQRLGLANLDWLVVRDLTLVETATFWKDGPELETGEMRTEDIATEVFFLPAASHVEKEGTFTNTQRLLQWREKALDPPGDCRSDLSFYYHLGKRIRQRLSDDEIDRPLRELTWDYPEEGEHRDPSAEAVLREINGTGPGGRALSAYTELKPDGSTRCGCWIYCGVYADEVNQAARRKPGREQNRVALEWGWAWPANRRILYNRASADPEGRPWSERKAYVWWDAEKGEWTGDDVPDFERDKPPDYLPPEGARAEEALAGTDPFIMQADGKGWLFAPAGLADGPLPAHYEPHESPVHNPLYGQQANPARKVYRSPAAPYNPPESPRFPYVLTTYRLTEHHTAGAMSRPLSHLAELQPELFCEISPQLAAEVGVVNGGWATIVTTRTAIEARVLVTERVRPLRVEGRLIHQVGLPYHWAWGSGGLVVGDVTNDLMPLVLDPNVYIQEGKAVTCDLRAGRRPRGKALLDLIEEYRHD
>NC_013595.1|WP_043652272.1|4135821_4136382_+|dehydrogenase
MAHGGWISRWPVIRQLRGEDARGDAARSARTDALRPRTEDADTVARSICPYCAVGCGQLVYVKDGEVTQIEGDPDSPISRGRLCPKGSASKQLVTHPGRQTRVLYRRPHGTEWEPLDLETAMDMIADRVVRTRRETWQQEEDDKVVRRTMGIAGLGGATLDDEENYLMKKLYTALGAIQVENQARI
>NC_013595.1|WP_012890393.1|4134375_4135569_-|ROK-family-protein
MVRPERRTVRDLRRGNRAVLLRTLYFEGPTSRHELSGLTGLSAASVSNVTGDLIADGIIVEAGLVESDGGRPRVLLRVDPEFGYAIGVDVGETHVRVELFDLDMNERAKADYPLRPGRHDVDLVVRHILSGIDAVLAAGGVDPARVLGVGIGVPGIVESGPEALIHAQTFGWDAVPLGTLLRAGTSLPLYVDNGAKTMGQAELWFGAGRGTRHTIVALIGSGAGASIITDGIAYRGANSSAGEWGHTKIMMGGRACRCGGRGCLEAYIGAESILDRAGLSAEIADEQAVLAELVRSGGPVIDETADYLGAGLANLINLFNPERIVIGGWAGLLLGRHHLTRIRRSAADNSLTQPYGTASIVLGRLGPDAVALGAATLVVEEFLLAKTVSPGRRSAAV
>NC_013595.1|WP_012890392.1|4133244_4134300_-|LLM-class-flavin-dependent-oxidoreductase
MAEDNIRGVARGTSDVPLSILELATVGSGVTATETLRASTELAGRAEKLGYHRIWVAEHHGMPSVATSSPAVLIAHLAAATTTIRLGSGGVMLPNHAPLIVAEQFGTLHALHPGRIDLGLGRAPGTDPATARALRRHGLDADDFPEQLAELTAFLDDAFPAGHPLERVVATPRSPETGRPPIWLLGSSGFSAQLAGLLGLPFAFAHHFSAANTIPALDLYRSSFQPSAVLDRPYAMIGVSAVAAETPEQALRMARSGGLSMLRLRRGAPQPVPTPEDAETYPYSPVEKDFLDDYLSKVVHGDAAQVRTGLEELRKRTEADELMITTLVHSPTARIRSYELIAQAYELRRSP
>NC_013595.1|WP_012890391.1|4132656_4133079_+|hypothetical-protein
MPSDPDHVLDAIDGAVDEWLAMSEDSMRWAPPEKAPPKRQLALPAPPLPRVSEEFLHDVGVLFGAQTQAVAEAVTEVFRPLGESLAEALAAFLDSPAVRQFVELVEPPGERALPGPAERDGLPPEPPPSPPPEPRSDGHP
>NC_013595.1|WP_052317196.1|4129269_4132236_-|discoidin-domain-containing-protein
MSLLISTLIALIASGLAVTAPAAAAAAADTLLSQGRAATASSTEGAAYGAAAAFDGDPATRWASAFSDPQWIQVDLGATATVSQVVLNWEAAYGRAFKIQISADGTAWNDAYTTTAGTGGTQTLPVSGTGRYVRLHGTVRATGYGYSLWEFQVYGATGPGPDPGAWTEVWRDDFDGTSGTSPSGANWILRTGTRYPGGAAKWGTGEVETMSASTANVSLDGTGKLNIRAVRDGAGDWTSGRVETQRTDFAPQPGERLRFTARLKQPDVPDATGYWPGFRATGAAYRGDYNNWPAVGETDIMTDVNGRSQLSNTLHCGTAPDGACNEYGGRTSGLATCEGCQTGFHEYTQIIDRTRSDEEIRFYLDGVQTWVVRQSQVGVSAWRAAVHHGFYLRFDLAIGGSLPDAIAGFTTPTAATTSGGVLSVDSVSVSRSAGTVPAPMTDPPTPAGPSTVRVTGGQGNWRLTVNGAPYEVKGLTYGPPQAAADGYMRDLRSMGVNTIRTWGVDDTHTPALLDRAAQQGIKVIVGHWLNQGADYVNDTAYKTATKNEIVARVNALKGHQGVLMWDVGNEVLLTMQDHGLPAPVVEERRVAYARFVNELAQAIHAADPDHPVTSTDAWTGAWTYYKDHSPALDLLAVNAYGAIGGVRQAWIDGGHNRPYIITEAGPDGEWEVPDDVNGVPSEPTDLQKRAQYTASWNAVKAHPGVALGATEFHYGLENDFGGVWLNTFTGGWRRLGYHALRQAYTGLPSGNMPPEITGMTVGSQTAVPAGGRFTVEVTASDPDNDQIRYNLMYSDKHVNGNRGFGHVGFTQTGPGRFSVTAPERLGVWKVYVYAFDGHGNVGIETRSFRVVPPPVGGTNVALGRPTTASSHQPTGDGGPFLPAKATDGSFTTRWASEWSDAQWLQVDLGQVTPVNRVRLGWEGAYGKAYQIQTSANGSDWSTVHSTTTGDGGFDTIDVSASARYVRLNLTQRATAWGYSLWEFGVYRS
>NC_013595.1|WP_012890389.1|4127542_4128892_-|DUF1996-domain-containing-protein
MHPPRSPGRFRLGLVAATLAALVAAGLAIITPATAADTLLSQGRPASASSVEGGGYGAGAAFDGSGGTRWASAYSDPQWLQVDLGATATVSQVVLDWEGAYGRAFKIQTSADGTSWTDIYSTTTGTGGSQTLNVSGSGRYVRMYGTTRSGGYGYSLWEFKVYGTGGIGSTPAPSPTFTDAVTHHEFQANCSWTANRPDDPIVYPGLPGASHMHTFVGNTTTNAGSTSSSLLGGGTSCTNPHDRSAYWFPSFYKGSQLIQPTGNQVIYYKSGILEYWRVRSFPQGLRFVVGSPTATLEQFRDSPGAVEGFECGDISHSWDIPTSCPAGSQVNVRYQAPSCWDGVNLDSADHKSHMAYPVNGYCSAGHPVPVPMLEFKIAFPASGDLSQARLASGRGYSWHYDFFNAWDNPAILNALVTHCINGGLQCNPRGYDLYKPHRGAALTENFELP
>NC_013595.1|WP_043652269.1|4124644_4127341_-|beta-glucosidase
MCRVTDEELGRMVEKLDLEQKVRLLTGATVWRTHAEPDIGLRAVVTSDGPVGVRGEGWDERSTSLALPSPTAVAATWDEDLVRRLGALLAAEARRKGVDVLLAPTLNLHRSPLGGRHFECFSEDPLLTGRIGAAYIGGVQSGGVAATAKHYVANDSETERLTLDARLDEQTLREVYLAPFEMAVEAGVWAVMSAYNGVNGTTMSESPLLTEPLKGEWGFDGVVVSDWGAVRSTAAAGRAGQDLAMPGPGGPWGDALITAVRAGEVSEAAIDDKIRRLLRLAVRVGALPGEQLGEGPPHREVPRAGASREGRERGQSPYGEPSREKRPHDEPPRGETTHGERPHGEASRGEAAHRERPHGEASRGEAAHGERPHGEAPHRGLPYGGAPAPAGAGDRALLRRAVSASTVLLRNEGALLPLDPARLRRVAVIGPNASGARIQGGGSAGVYPASVVSPLEGIRSALSGVARVDHAPGVHTTNLPTPLGLGNARDPLTGEPGVLVRLLDGAGAEIHAEHRLTGRILEPASVGSAATVEIRALLRPDTDGVWNLAVAGWGRVRLEADGRVLVDEEIERDTDDPATVHLSPPYRRARLGLTAGREVELVARRRLVPGSGVASVLAADPPRLDDDAELTAAVELARACDVAVVVVGSTDESESEGVDRVSLDLPARQDELVRAVAAANPATVVIVNSGGPVALPWREEVPAVLLSWFPGQEGGHGLADVLFGVAEPGGRLPTTWADGALATTTPVDGVLAYEEGPDIGYRAWLRAPAPPAYWFGHGLGYTSWSYESVHVPGRVEPGRPFPVRVRLRNTGERAGREVVQIYLERPDTAVTRPARWLAGYAPAEAGPGESVELTVDIPARALRHWSAEDHTWRTEPGAFTVLAGRSAGDLPLSAVTAL
>NC_013595.1|WP_012890398.1|4142703_4143579_+|glycosyltransferase-family-2-protein
MTLPRIGVVIVTMGTRPRELDALLASVAKQDVAPERVVLIGNATPLTEVSADVTKIPLKENLGCPGGRNVGLELLCESGEVDVIVELDDDGLLVADDVFRMIRQLYASDPVLGIVSFRIADERGETQRRHVPRLRAGDPMRGGPVTAFLGGAHALSVPMLNEIGGWPGQFFFGHEETDLAWRALDAGWKILYEPGLVLQHPKTSPARHAMYYRLTARNRVWLARRRLPRPLVPVYLATWILITLLRTHSASGLKTWTAGFLEGLRADCGERKPMKWATVWRMTRLGRPPLI
>NC_013595.1|WP_174435293.1|4143715_4144084_-|NUDIX-domain-containing-protein
MVGVTGIVRDGEGRVLLLRHRMWPPDRQWGCPTGYADKGETFEDTIVREVREETGLQVKPGRLVQVTSGYRLRVEVAYEAHLTGGTLAIDSTEILEATWFSPHNLPDGVQESHRLLIQRTQP
>NC_013595.1|WP_012890400.1|4144769_4146263_-|MFS-transporter
MRVNRAWLGLVVLVLPTLLVAMDTTALLLALPQLSADLGATNVQQLWISDSYGFMVAGLVITTGTLGDRIGRRRLLMIGGAAFAVLSVVAAFAVSPLMLIVARALLGVAGATLVPSTLALITNMFRDERQRGQAIAIWATCQFTGGALGPVLAGSLLQHFWWGSVFLVAVPAMALLLLAGPVLLPEFRSDQAGRLDLAGVGLSLVAVLLMVYGIKQLTVESMPVVPAVALVGGAAIGFLFVRRQLRLETPLLDLRLLRNRPFTAVLVALAFAGIAMAGTGLLVTQYLQSVLGFSPVASAVLFAPMGLGVAVGTMAAPALARRMKQTTAIAGGLVGSALGSLLLVGVDGARALPLVMVGIAVLALGTGPLFALGTGLVVGSVPPERAGSAASMSETGNYLGGSLGFALLGVVSAVIYRGRMDGTSDSLAGAVAASRHLPAGQGAELLHTAREAFTAGLHVTGVVAAVIFAGLALLILTMRPATRTTPAALPDYEATRS
>NC_013595.1|WP_012890401.1|4147074_4147650_+|DoxX-family-protein
MNRHASESLLGAKDIEQQPKGRATRFTFNGALWSLQVLFGFFFAGSGFGKVLLYDGALYAAAPRAVAWYAAVPQSLIVFIGVCEVLGGVGLILPAMTGVKPKLTPLAAVGLTLTMILAAGFHIMRSEYGLVPANLLLGGVAAFIAVGRWKLRPIAPAIITTPRALKSFAVLGALALLVFAPTWYTMTNVQF
>NC_013595.1|WP_012890402.1|4147816_4148155_+|hypothetical-protein
MRFHKTLTIAATLALSSALTLTVTTTPAHAATCTKGWSADLHTAWIDCDNGFTTGRFRLKALFCSGTGCSWRYGPDKYYQGGGASSHTDAIWVDVNNITYEDRGPGSLVPTS
>NC_013595.1|WP_012890403.1|4148660_4148948_+|helix-turn-helix-transcriptional-regulator
MTVRDWLRLDEKAMMVGMLDQAAIIARIRALRLARGLTIQYLADQTGIHRSIIGKLERGKRKTFNLDEARALCEALKVDLRVVISDEPMSIIAKS
>NC_013595.1|WP_012890404.1|4149092_4150382_+|L-seryl-tRNA(Sec)-selenium-transferase
MDSRRRVPRTDLVLADPRLVATAGRLGRAVVKEAVAQAQRRVRQGEIAPEEVVDAAVAALPPYATRMRPVINMTGVLLHTNLGRAPLSPAAVAAAMAAAGSSDVEFDLATGARARRGRATLDALARAVPAAEDVHVVNNNAAALVLVATVLAAGREIVISRGELVEIGDGFRIPDLLVSTGARLCEVGTTNRTSYADYAAAVGPQTGFVLKVHPSNFRIEGFTGSVGVAALSDLGVPVVADIGSGLLAREPLLPEEPDAAGVLRAGADLVTASGDKLLGGPQAGLLLGRRDLVDRCRRHPLARALRVDKLTLAALEATLRGPATPVHEALHADPAALGERAGALAGRLAEAGIDARALPSEATVGGGGAPGVTLRSAAVSLPERFAVPLRTGEPPVVGRVEGGRLLLDLRTLPPGRDDDVVRAVLGADG
>NC_013595.1|WP_012890405.1|4150381_4152157_+|SelB-C-terminal-domain-containing-protein
MHVVATAGHVDHGKSTLVRALTGMEPDRLAEERRRGLTIELGYAWTTLPSGERLAFVDVPGHERFLGTMLAGVGPAPAVMFVVAADEGWMPQSEEHLVALEALGVRHALLAVTRADLADPEPAIGRARARMAASGLGEVEARAVSGRTGQGLGELREALDRLVAALPVPGPQAPVRLWIDRVFSVRGSGTVVTGTLPEGTIAVGDELMLPGGPVRVRGLECMNEPLTSATGVARVAVNLRGHGVPERGQALVTPGGWTEADLVDVRLSPVGAGRAGGDLPPRLTAHIGSAAVVCEVRPLGGPIVRLRLARALPLHLGDVLLLRDPGRDRSEVRVLAGASVLDVRPPALRRRGAARERAARLAAARPDAASLLRDHPLLRAGDLLAMGCAPAGRPVCGDWHADPAYWAALGERLAEAVRRHAAEHPLEPGMPVEAARHGLGLPDRRLVAALVRPPLAVADGRIVSGPRGLPAPVAPAVGRLRAELSAHPFRAPEAGRLAELGLGPRELAAAVRAGALLRVADGIVLPPGAEARAAELLARLPQPFTVSQARQALDTSRRVAVPLLELLDRSGLTERVDELHRRCRPPAPGGA
>NC_013595.1|WP_012890406.1|4152514_4153741_+|formaldehyde-dehydrogenase,-glutathione-independent
MTDNKGVTYQGPGKVEVQTIDYPEFELKDGPGVNPANVGRKVRHGAIVKTVATNICGSDQHMVRGRTTAPPGLILGHEITGEVVETGPDVEFIKNGDLVSVPFNIACGRCRNCKEGKTGVCENVNPDRPGSAYGYVDMGGWPGGQANYVLVPYADWNLLKFPDKDRAMEKILDLAMLSDIFPTGFHGCVTAGVKPGSTVYIAGAGPVGLAAGVSAFLLGAAVVIIGDLNKDRLAQARSFGCETVDVSQGEPKDQIEQILGEPEVDCGVDAVGFEARGHGSEAGTEHPATVLNSLMEITRAGGALGIPGLYVTGDPGAADEAAKQGSLSIRLGLGWAKSLAFTTGQCPVMRYNRQLMMAILNDRVQIAKAVNATPISLDQAPRGYEDFDKGAARKYVLDPNGMLGTAAS
>NC_013595.1|WP_012890407.1|4153869_4155960_-|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit
MTTTTPSSVGSGLDRVEGLDKVTGRARYAFEYSPRDLAYAVPVQASVARGEIRSVDVDAVLKRPGVIAAIWYGNAPRLASGDGGELAVLQSPRVAYRGQYIGAVVAETLHDAREAAGLVRVEYAAERHDVELRADHPGLYRPEVVNPNFPADVEQGDPDAALAAAPIVVDAVYSTPAEHQNPMEPHATIAAWDGDGLTLHDSTQGASAVRDTVAALFGMPPANVRVISPHVGGGFGSKGTPHPHLVLAALAAKQVGRPVKLAVTRQQMFAVTGYRTPTIQRVRLGADAGGRLTAIVHEAFEQSSTIKEFAEQTAVPTRMMYAAPARRTTHRLVRLDVPTPSWMRAPGETPGMFALESAMDELAIACGLDPVELRIRNEPDTDPETGLPFSSRNLVACLREGARRFGWAGRDPAPGVRRRGRQLVGTGVAASTYPAYRGSSQASARAEPDGRFTVRIAAADIGTGARTVLTQIAADALRAPVDRVRVEIGDSALPTAALAGGSMGTASWGTAVVRACEALLKELDRRDGDLPADGVEASADTTEEIRGQQRFARHAFGAQFAEVGVDADTGETRVLRLLGVFAAGRIVNPKTARSQFIGGMTMGLSMALLEESVMDREFGDYLNHDFAQYHIAACADVRDIEALWVEEDDPHLNPMGSKGIGEIGIVGTAAAIANAVHHATGVRIRDLPIRLDKLVR

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Crispr_ID: NC_013595_27

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_27

4337086-4337174

Orphan

Consensus_repeat	Method
CTGCCCGCCGTACCGGCTCATCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_27

>merge|NC_013595|27|4337086-4337174|CRISPRCasFinder
CTGCCCGCCGTACCGGCTCATCGGGCGGTCCCCGCCGGGGTGGTACGGCGGGCAGACCCCCACGTCTGCCCGCCGTACCGGCTCACCGG

>NC_013595|27|25|4337086-4337174|CRISPRCasFinder
CTGCCCGCCGTACCGGCTCATCGG	GCGGTCCCCGCCGGGGTGGTACGGCGGGCAGACCCCCACGT
CTGCCCGCCGTACCGGCTCACCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_081453433.1\|4335430_4335967_+\|lysoplasmalogenase	unknown	unknown	gnl\|CDD\|377946
NC_013595.1\|WP_012890547.1\|4331981_4333142_+\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225807
NC_013595.1\|WP_012890558.1\|4344013_4345009_-\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|293786
NC_013595.1\|WP_043652322.1\|4336502_4336712_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043656055.1\|4338930_4342113_-\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349873
NC_013595.1\|WP_012890559.1\|4345032_4345704_-\|endonuclease-V	unknown	unknown	gnl\|CDD\|143472
NC_013595.1\|WP_043656058.1\|4346507_4346804_+\|thiamine-binding-protein	unknown	unknown	gnl\|CDD\|376658
NC_013595.1\|WP_012890549.1\|4334400_4334796_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_013595.1\|WP_043652325.1\|4342302_4343265_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_013595.1\|WP_012890545.1\|4325798_4329791_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|283431
NC_013595.1\|WP_012890543.1\|4319551_4324450_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012890562.1\|4346973_4348089_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293841
NC_013595.1\|WP_012890560.1\|4345730_4346474_+\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225758
NC_013595.1\|WP_012890557.1\|4343452_4344001_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012890552.1\|4336063_4336420_-\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|366841
NC_013595.1\|WP_012890548.1\|4333332_4334136_+\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|252734
NC_013595.1\|WP_012890544.1\|4324626_4325802_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|336785
NC_013595.1\|WP_012890554.1\|4337212_4338685_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_013595.1\|WP_012890563.1\|4348104_4348881_-\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|313370
NC_013595.1\|WP_148269129.1\|4329754_4331848_+\|SWIM-zinc-finger-family-protein	unknown	unknown	gnl\|CDD\|236090

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_081453433.1\|4335430_4335967_+\|lysoplasmalogenase	gnl\|CDD\|377946	pfam07947, YhhN, YhhN family. The members of this family are similar to the hypothetical protein yhhN expressed by E. coli. Many are annotated as possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues. A human member of this family, formerly known as TMEM86B, is a lysoplasmalogenase that catalyzes the hydrolysis of the vinyl ether bond of lysoplasmalogen. Putative conserved active site residues have been proposed for the YhhN family.	4.84855e-23
NC_013595.1\|WP_012890547.1\|4331981_4333142_+\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	gnl\|CDD\|225807	COG3268, COG3268, Uncharacterized conserved protein [Function unknown].	5.50957e-57
NC_013595.1\|WP_012890554.1\|4337212_4338685_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.42821e-61
NC_013595.1\|WP_012890558.1\|4344013_4345009_-\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	1.76676e-16
NC_013595.1\|WP_043656055.1\|4338930_4342113_-\|M28-family-peptidase	gnl\|CDD\|349873	cd03876, M28_SGAP_like, M28 Zn-peptidase Streptomyces griseus aminopeptidase and similar proteins. Peptidase family M28; Streptomyces griseus Aminopeptidase (SGAP, Leucine aminopeptidase (LAP), aminopeptidase S, Mername-AA022 peptidase) subfamily. SGAP is a di-zinc exopeptidase with high preference towards large hydrophobic amino-terminal residues, with Leu being the most efficiently cleaved. It can accommodate all except Pro and Glu residues in the P1' position. It is a monomeric (30 kDa), calcium-activated and calcium-stabilized enzyme; its activation by calcium correlates with substrate specificity and it has thermal stability only in the presence of calcium. Although SGAP contains a calcium binding site, it is not conserved in many members of this subfamily. SGAP is present in the extracellular fluid of S. griseus cultures.	4.8194e-118
NC_013595.1\|WP_012890559.1\|4345032_4345704_-\|endonuclease-V	gnl\|CDD\|143472	cd06559, Endonuclease_V, Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases. Endonuclease_V (EndoV) is an enzyme that can initiate repair of all possible deaminated DNA bases. EndoV cleaves the DNA strand containing lesions at the second phosphodiester bond 3' to the lesion using Mg2+ as a cofactor. EndoV homologs are conserved throughout all domains of life from bacteria to humans. EndoV is encoded by the nfi gene and nfi null mutant mice have a phenotype prone to cancer. The ability of endonuclease V to recognize mismatches and abnormal replicative DNA structures suggests that the enzyme plays an important role in DNA metabolism. The details of downstream processing for the EndoV pathway remain unknown.	1.19606e-99
NC_013595.1\|WP_043656058.1\|4346507_4346804_+\|thiamine-binding-protein	gnl\|CDD\|376658	pfam01910, Thiamine_BP, Thiamine-binding protein. The crystal structure of two of these members shows that this domain has a ferredoxin like fold and is likely to exists as at least homodimers. Sulphate ions are are located at the dimer interfaces, which are thought to confer additional stability. Although the function of this domain remains to be identified, its structure suggests a role in protein-protein interactions possibly regulated by the binding of small-molecule ligands. Solution of the structure of the hyperthermophilic anaerobic Thermotoga maritima sequence, UniProtKB:Q9WYV6, shows that this has a beta-alpha-beta-beta-alpha-beta ferredoxin-like fold and assembles as a homotetramer. It was possible to identify a pocket in each monmer that bound an unidentified ligand. It was also found that it bound charged thiamine though not hydroxymethyl pyrimidine. It is proposed that it is transporting charged thiamine around the cytoplasm. Under oxidative conditions this bacterium is under stress, and the transcriiptional unit within which this protein is expressed is up-regulated in these conditions, suggesting that the chelation of cytoplasmic thaimine is part of the response mechanism to such oxidatvie stress, which is mediated by this family.	6.43946e-26
NC_013595.1\|WP_012890549.1\|4334400_4334796_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.07804e-07
NC_013595.1\|WP_012890545.1\|4325798_4329791_+\|VWA-domain-containing-protein	gnl\|CDD\|283431	pfam05762, VWA_CoxE, VWA domain containing CoxE-like protein. This family is annotated by SMART as containing a VWA (von Willebrand factor type A) domain. The exact function of this family is unknown. It is found as part of a CO oxidising (Cox) system operon is several bacteria.	4.2416e-45
NC_013595.1\|WP_012890560.1\|4345730_4346474_+\|MOSC-domain-containing-protein	gnl\|CDD\|225758	COG3217, COG3217, Uncharacterized Fe-S protein [General function prediction only].	1.05887e-26
NC_013595.1\|WP_012890562.1\|4346973_4348089_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293841	cd16283, RomA-like_MBL-fold, Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain. Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	6.55654e-71
NC_013595.1\|WP_012890552.1\|4336063_4336420_-\|PIN-domain-containing-protein	gnl\|CDD\|366841	pfam01850, PIN, PIN domain.	1.22112e-05
NC_013595.1\|WP_012890548.1\|4333332_4334136_+\|SAM-dependent-methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	7.48433e-107
NC_013595.1\|WP_012890544.1\|4324626_4325802_+\|AAA-family-ATPase	gnl\|CDD\|336785	pfam07728, AAA_5, AAA domain (dynein-related subfamily). This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.	7.93842e-42
NC_013595.1\|WP_043652325.1\|4342302_4343265_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	3.15684e-21
NC_013595.1\|WP_012890563.1\|4348104_4348881_-\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|313370	pfam10127, Nuc-transf, Predicted nucleotidyltransferase. Members of this family of bacterial proteins catalyze the transfer of nucleotide residues from nucleoside diphosphates or triphosphates into dimer or polymer forms.	6.10139e-51
NC_013595.1\|WP_148269129.1\|4329754_4331848_+\|SWIM-zinc-finger-family-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.79075e-05

>NC_013595.1|WP_043652322.1|4336502_4336712_-|hypothetical-protein
MTIYAGMNGPANASDPEAVDYEAIRRRFPWVGCFDSGEDDLSSRYRDMMAEALRDREIVEAIDAARHRP
>NC_013595.1|WP_012890552.1|4336063_4336420_-|PIN-domain-containing-protein
MLGSWPGSLVIPEPVLGETCSFLRNNVRRGAFLEATLLEQLTVGNYEIVNPTQADRQRATELVRHMVAAPLGYVDATVIAMAERLHITDVATTDLKFVGMTQGITKIRPLAWPFHESH
>NC_013595.1|WP_081453433.1|4335430_4335967_+|lysoplasmalogenase
MNSMTKALLMPLLAVWVLTQRGPRPVVAALLLSCGGDVALEIDGLFLVGMVLFAGAHVCYVTYFVREGALDGLRRRPVIPVVYAVVWAGLVFFLWPGLGDLRLPVAGYSLLLTATAVTAAGHGLRIGAGGALFLLSDTLIAFDLADLPLPPMNGLVVMATYIAAQYLLASGIVNRLRA
>NC_013595.1|WP_012890549.1|4334400_4334796_+|GNAT-family-N-acetyltransferase
MTIAYEWRGHFDNAAINALHAEGFGHAPLKDDWWAQVNRHSLGWVCAKENGELVGFVNVAWDGAVHAFILDTLVTGRARRHGVGTGLVAVAVREARAAKCEWLHVDFDDDLKDFYFGACGFQPTHAGLIAL
>NC_013595.1|WP_012890548.1|4333332_4334136_+|SAM-dependent-methyltransferase
MADKPSERNAGIDTTRPSIARAYDVVLNGKDNFEVDRAFVAEIVKVIPEIYDVAAYNRQILGRGVRFLSGQGITQFVDLGSGLPTEENTHQVAQRANPESRVVYVDNDPMVLAHGRALLAENDRTAVITSDLRDTEAILSDPAFKSLIDLGRPVAVMLVGILHHLHDDEDPRAIVEAYMAAVPSGSYLFITHFCASTQESRDAEQKYLALLGTGRFRTPEEITAFFDGFELLEPGVVPLPLWRPDGPVPGKLTVGQQLMYGGIAYKR
>NC_013595.1|WP_012890547.1|4331981_4333142_+|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein
MSDDRPYDIVLFGATGFTGALTAQYLARNASPGCRWALAGRSRTKLEAVRERIGLPELPLLHADATDPASLARIAGQARVVATTVGPYVAYGEPLVAACAAAGTHYADITGEPEFVDLMFARHHERARRSGAKIVHACGFDSIPHDLGAYFTVNRLPEGVPIEVSGFLRGNGRPSGGTVHSALAAVSRARQTARAALARREVEERPQGRRARGTAGPPRYVGGWALPLPTIDPQIVARSARALERYGPDFTYRHHIAVRRLPAALGLVAGAGALVALAQIPPVRSWLLGRISPGDGPTPEQRAGSWFKVTFLGLGGGERVVTEVAGGDPGYDETAKMLAESALCLALDDLPPVSGQVTTAVAMGDALIERLRRAGITFTVLSGPPK
>NC_013595.1|WP_148269129.1|4329754_4331848_+|SWIM-zinc-finger-family-protein
MGGRPPSRRVPVNSSTSTVPPAGQLPPAAPHVVAAAVEGLTSRLRKKLDAAIEQYAATPAVADGESIRISCGEDTVVTLSPGASGVITDDGQACCSCLLAPRCLHRAAVLSACPVADAGAGAGTDTGTEMGAGADAGAGADTDAGAGAGTGAGADAGAGAASGPPDVHLSGTGSATARDDPSHGGTAAGTPAGPTAAQVAAASGLWAAAAATLSAGVPAAGAVPQAELLRAAHTARLAGLPRAEAAALRVVRGLRAARERHDGHRLADLVAALRELLLTAGRLAAADPDPALVGSVRRSYQPGGSLRVYGVFREPVISGTGYGGVVTHLVTEDGRWFSVADVKPGGPARARGAATAPVAIGPAMLNHAQLARAGLLIAGATVSPDGRLGAGGGVRATPINGMSWTAGPMAALFARPLAEAVGARLSGQAWNESEAAERAQEPVGCDLVIVGAAGDHVLARELLPAGTPPERSGPEGDDPARRPPPTVRPDGPLIRLIPAGSHPDLAHVANLRQLASRPGTLVRVVGRLDPDRAATLRPLAIGPVPGTEATLRLPAGWQGRADLGYDRLQGSHLPPHDACAPWQAAPEADVDPVADAPLWRVRRLVELAVAGGRRAVAERARSGDSRAQGAPLRRAGFEAAAELAAALTAEADRRSRDVFGRSTDSGPDGYAWAWLAAAIHLAAADQALVRASWHSGY
>NC_013595.1|WP_012890545.1|4325798_4329791_+|VWA-domain-containing-protein
MTCHSEPETGQDARRSARHGGEADPRRAVAALASSARPYLLGVRHHSPALAVVLPALLDAADAEVVCVELPADFQPWLAHLADPGTLAPVALAGADGEGRLGFYPFADFSPELVAIRWARQRGAEVLCCDLPLSDPGWHAPGTAQASDTAQASDAGTAQAPGTVRSPDPARPMGPDAVPVPAGAAASRGTSFAAALAASGTGREGDDMWDRAVEVLAPGCEPEAVRRAALGVGWALRRDAEAAGGVPAVDMAREAHMRRVLEDAAAGGRRVAAVVGAFHAPALIIPDTAEPGRTGADGAAPPPGTAGGQATSGRPATDGEVVPPPATDGAVAALPAMDGEVVLPPATDGAVAAPPAVPSARAGSPAATSLVPYAFDLLDSRSGYPAGIRDPRWQQTVFMAGGDPGRVRDGAARAITGLCRELRSAGHTAGTGEAVEALRLACDLARLRGLPSPGRGELLEAVTTVLGQGEPLGRGRALARALDAVFVGTDRGRIAPGTPRSGLGPAVEADLAALRLPCPDNPERREVRLDPLRSDLDARREVALQRLLLCGVGYGEPIEVTGTGDSTALTTRWRLSWTPAVPALLDLAGVRGVTLAQAAAGTLRETFRRESAEGGPTCGLILSGLRAAARCDLPELVADRLADAAVALPATATLAELLDALDLLEALRREHLPGTTPEGREQAAELAGTLLEAAVRALPGLAGSDQPQDAAALVALATRAGEERLGLRMDDTLAALTGTASPLIQGAALAARVLLDLDGPGTLGARAAGWVGAATGPDGRHRLSRLLTGVLTAAGPLLQSAPAALDPLMDRIDGLADRDFLDRLPALRGGFDTLTPAGRTRLLGAVSERLGDRLDLTLSAPPGLLALWSAADAAGLAALHALRLPVPASAPALAGTPSDAPEPPAPDRRPARDGEEVEDTQEPPSPEAGAVTEDPRTPARPETAEVTEAGPGARRRFTPADRWRLLLGRESERLPAGARSYARALDELYGTGRGEGAGHFGQSPGEGGDSGGRGDSFPTAREWAEELEVLFGTEVREEVLARAADAGRTDVLTELDPAAVRPSVELLTSVLTLAGGLPEQRLAKLRPLVRRLVAELTRELATRLRPALTGLATPRPTRRPGGRIDLPRTLRANLQHTRRMGDGRLVVVPERPVFSTRARREADWRLILVVDVSGSMEASVVWSALTAAVLAGVPTLSTHFLSFSTEVIDLTDRVADPLSLLLEVRVGGGTHIAAGLAHARSLVTVPSRTLVVVVSDFEEGYPIGGLLGEVRSLAGSGVHLMGCAALDDSGVPRYSLPVAQQLVAAGMPVAALSPLALARWVGDRLRGESR
>NC_013595.1|WP_012890544.1|4324626_4325802_+|AAA-family-ATPase
MTMTDDQVTVPPARQVLAAEERYATELAFLAAHDAGPRPPGWALTPRAVVTFVCGSGDETLELPKNRRGTAGGAPDRLRVAAKFVGERALVERCVVTLAGERGLLLVGEPGTAKSMLSELLAAAVCGTSALTVQGTAGTTEDAFRYGWNYALLLAQGPSRDALVDSPVLTAMRAGRVARVEEITRCLPEVQDALVSILSDRRLSVPELAGTADAQVAATPGFSVIATANLRDRGVSEMSAALKRRFNFETVDPIADAEAETSLVRRQATSVVQRAGAAFGVDDAVLDALVTVFRDLRSGRSDEGWDVERPGTVMSTAEAVQVAASLGVAAAYLPDGDVLDLLPGHLLGVVRKDDPADHGRLLGYWDGPVRRRAEDGSAMWRRLWDLRENLR
>NC_013595.1|WP_012890543.1|4319551_4324450_+|hypothetical-protein
MSQAEARTAELLKAGAVLPPDTEGAGDRAVPLTARRYRHPGLDDRVVVRLVAGELGAAEDLAAGFLGLEPDGEPAVVGLGARRSLGFPEWVLVHHPGDGHHALAVVPELERTARQVKSKPKAALDAYQRLAGQLAASVPHFLPTFYEQAGRVFLGVENTTYAAQMFAQARKAEAEHGLAVDEDRLDAVFLEFALAGALPVKVLSGYAREMAGRLPADEALRRFTRLCVRRTAGGLPPSAQMANDLRRLARAAGADAAEAEQAYLAELLGLPATQRAAAGWWKAHRPAVASLGRREPEVRGTLLNSMPQVRDGELPGLWLEILEESGATAGLAGGEVPERERPADGTAGWLGRFLLARDRAGGIPPRLPSLYTLVERVADRLRAELAEPGRKAPTVEYDVDLLDLLLALDIPVADPDERRSLHLIPWAKGEGRRDLLALAADPRFRPAFQRGADGFGANEYGQRAVRVLAESPGGRPMLAEWMRKVALRSSAAGLPELPDAMRRLSWLPGEALVLAEEEVRQAAGADVALVLARTLRAGLFDELGWPAWEEAAETLVPRKDVDDLVVADAWPHLIVAGPSQVRVLSAEGTVLTHDLRVPAGDTWGDDHGFHYVDGELLVYWHSRQLGSELRGYWHTSADRIHLLEGIGSTRGTRLNWYRGDDPVSLPLPGGGRTTGQGVLHPGDTAVPGERSVITDGTSFWVWTWDGSDHESTGWYEYDPLSGEQGRKGVPGFLADALRTAPAGSTFRSGWLLPAPSDGPTPVGTPVGGLFGWRVVVLPDGSMRGEDLSGRAVTVAPDSRAPLRALTFPGDDRPRAVVKNGGYQVDLVDLDGVVTAVAKTDNVPGAFAAGTLVLPPPRYWHCLRPRDPEGSALLRRMDRDTSAALLEAVVAGGETGEEELRARIRALLPQVSHDALVAGITGVVRFAAARQAELDAVAARLSEALAGGHREESPTGPVDRLLNQALSGLGGSADNSWHSQELDGAFRQIQSIGQALAAAPSEAPPGRLHLDLPESPPAGLNWAPLLDHSAALAFRAATATIEEEHRTALHALLRDLRDLGLPAAADPSRWRRMSLHLEKHHLPVVDGSLRRGTWLGVLPLGGGALLAFVSRSSPDDSGCVWTALFHDPAGRFDVPSPYTVRSSSPVGEDRREGWLGAFLTELAERGPAPWRPEAAEEFARLTGVSQTVARLVVAGLPYVDAYERGFITKEARATLGVKMADAAVAKDELRKLSAHARRAVVAALLPEDPARLWTDGPDAAGAAQVWNSEVGRQAAIPEWLLGEAARAVRTGWDTGRALRALADPAAAPELSRDLVWGVNGDRVRPVDGNATGFTASTLVTAVATAGWLAHRLPAGDPIRAALPRALAMVRDRLAGPELMLDLGRYVDLPGFRKAAGAPTEIGEGYERYGAVIMATYDTRPAPGIRTALLDAAGDDPYLRALVGSEGSFPVETALRTARDPRFEALLADPGDPVEGERDADGTWWPQDPTRSVPELVVEVAKEHGLGEDAAVLYLTLLAMPDPTDRNVARWTGWKPARLKEARAELAAGALVVEANRARAGRSLFLPGGWTELKAPCLPLEQWKLPLFDGAGSQSTPIVPIQPAADLYRRAWQRVRDGDAPRFEELRVRRGRRR
>NC_013595.1|WP_012890554.1|4337212_4338685_-|MFS-transporter
MSTGARPGGTSTARRSDGADPRRWKALTVCLVAGFMTLLDVSIVNVALPSIRAGLHAPQSDLQWVVSGYALTFGLVLVPAGRFGDMRGRRNAFVFGVALFTLASAAAGVAQNSTWLVVARLVQGVAGGVINPQVSGLIQQLFRGAERGRAFGLLGATIGISTAIGPLLGGLLIHLGGGQEGWRLVFYVNVPIGILAVVLAYRYIPHRTREERRRESMDPVGVLLLAAGVVLVLLPLVEGQEWQGGGKWLPPAAGVVVIAAFAGWEHLYGRRRDPVVNLSLFSRRSYALGALIAALYFAGFTAIFFVLTLYLQDGLHYSALAAGLASTPFAAGSAATSVLGGPVVTRFGRPLVVLGLVLVSVGLAATELAVRLVPGPQVAWAIAVPLLVAGLGSGLVISPNQTLTLSEVPVAEAGTAGGVLQTGQRIGTAVGIAGIGSVFFAGVASSHGDYALAFRHALLVTIGFVLVALAVALADVAADRRARRNRAAAR
>NC_013595.1|WP_043656055.1|4338930_4342113_-|M28-family-peptidase
MTATSVVSAAGAATAPAGIVARTISADPPAFAPPDPESRKRAISSADGALALRSDVLFKAAEDDFTLTNTVAGTRGLQYLTYSRTHRGLPVYGGDVVVTTDKTGQEVGSVASGQRAEIKVGVKSKVDATTAAVTARGELPTVESVSTPRLVVHAAGKRPRLAWEVVVTGATKQAPSVLHVFVDALDGSVVDSYDDVRAGTGNGFYNGNPVTIQTSGSGGSYSMTDTTRPGLRCGGQNGSAYTGTDDAWGNGQGTNLETACVDALYAAQTEWNMLRDWLGRSGFNGSGGAFPARVGLTDVNAYWNGSYTNFGRNQANTQQATPMDVVGHEYGHAIFQFSGSGGAGSGNEAGGLNESTGDIFGALTEHFAANASDPPDYLVGEEVNLVGQGPIRNMYNPGALGDPNCYSSSIPNTEVHAAAGPQNHWFYLLAEGTNPGGGKPSSTVCSGPSSLTGIGIQKAGQIFMSGLNSKTTPWTHAKARSTTVAAAKQLFPNSCVEVNATKAAWAAVNVPAQSGEAPCTANPGNDFSLSLSPTSGSVQAGQSATTTVRTTVTGGNAQSITLRASGLPSGATASFSPATITAGQTSTLTLATSGSTPSGTSSVTVTADGADVDRTASYSLTVGTGNPPGAPDIPVANVTAHLNQLQSIASSNGGNRASATSGYTASLNYIKGRLDAAGYTTAVQNFTYNGQTHSNLIANWPAGPTGPTIMLGSHLDSVSSGPGINDNGSGSAALLEVALTLANRNPTLDKHVRFAWWGAEELGLRGSQYYVQNGGATGVETYLNFDMIASPNPGYFVYDDNPAIEKIFKDYYATLNVPTEIETEGDGRSDHAPFKNAGVPVGGVFTGASSVKSSAQATKWGGTSGLAFDRCYHSACDTTSNINSTALDRNADAIANALWKLAVGDTPTPTDDYSVSASPSSASVQPGQSAGTTLSTQVTSGNAQAITLSASGLPAGATASFSPANINSGQSSAVTIATSASTPTGTYTVNLNADGASSDRSATFTLTVGGGQGGTTWQTWTLYAAGDTVTYNGVSYRCLQGHTSLPGWEPPNVPALWQQL
>NC_013595.1|WP_043652325.1|4342302_4343265_-|LysR-family-transcriptional-regulator
MDLEVRHLRAICAIAESGSISKAATALKMSQPALATQLRRIERMFGGPLFERGREGTRPTQLGTWVLIRARSLLPAFDELRRDGMRYAEQAAEKLKIRLGCMSSHLAINVIKCLNELLTGADITVRTEEAMDLLPGLLESERLELATLGDYPGHELLPPPGVVYAGVAVEPIFVGLAVSHPLAQREEIELRDLASEDWTLHALAEAGHREHFWAACGRQGFAPKIAYSADLSLAIDLISSARCVGMFQATSKGYPGIVIRPLAGTPLRFRHMIGWTEHGPVARHGPDLVQAVTKTYWAEVRRAPVYASWLKRHLPLSPPV
>NC_013595.1|WP_012890557.1|4343452_4344001_-|hypothetical-protein
MRKHTITAVWEEIPDDADDLVLVRGGFRLYLCLCGTHLADRAAAELHAAETNQCTTCLGSATEEIVPGFSQECTACAGTGRRKAQLTWELAYVEAETMITVDLVRTVIAPFTEPFQLSLVADTVRSTLGLPVGRLPVGPRVRDVLRQLEAAGELTLVSAPDELLRGTTVVLYRDPYWQHASE
>NC_013595.1|WP_012890558.1|4344013_4345009_-|ankyrin-repeat-domain-containing-protein
MGTTVSDNEWVGGAGAWSDTNLAEIQERLADGFDPGQRLFWLRSTPLHQAAQEGAVKVIELLLASGAEVDPADSYGATPLWEAVRHGQDDAVRLLLAAGADPWRPCIAGRSPGLQALFTELADLFAHLPGAPRVSPRLRELQETVDEMMFSYEDYNEGFCIAFVGEVAEDEVIRRLGADPGLCPPVEAGALWEAEHASPAELLRVASPPGGGVVLIQTEGVLPVHDGVARRVTTGGGVLAGAFPLAGTSVDIWRDGFSIARPSVHEQLSDDSLFELWMCRFGDCGAHPSVSMERILALMTLLTATYVTEEWLWSAPMRLVPVELRSDGQGR
>NC_013595.1|WP_012890559.1|4345032_4345704_-|endonuclease-V
MKAQTPRTILEAEAIQDELRPLLDLTGPGPGTPATVAGVDVAYDGERLAAAVAVLDASTLEVVEQVTVGGRVAFDYVPGLLAFREVPALLEALERLTVTPDLVVCDGYGLAHPRRFGLACHLGVLTGLPTIGVGKTAFVGSYPDPAPERGSWTDLTLDGDVVGRVLRTRHGVKPVFVSVGHRVDLDTACRNVLALTPHYRLPETTRVSDRLSRLALIENVTFD
>NC_013595.1|WP_012890560.1|4345730_4346474_+|MOSC-domain-containing-protein
MKTHSGSLRRLLRWPVKSLRGEELQEALFDDRGMAGDRAYSLVDDRDGPAGKVLTVRRRSEMLHWRAAYGSGDAPELTAPDGTVWQWHDPGLAGALARSLGTPLHLRAADGQQDRGPTVLVTFEASLVALEEELGAPVDLRRFRPNLHLGLDAPAFAEEGWGPGTTLTVGEVELAVTGDHTGPCIRCAVPSWDPDGRERWPGLQKWLIREHENKFGVIMRVTRPGTARRGDRAVADPRPAAGEIRVR
>NC_013595.1|WP_043656058.1|4346507_4346804_+|thiamine-binding-protein
MLVAFSVTPIGAGEDVGELVAEAVRVVRASGLPNRTDAMFTTVEGESWDEVMGVVKGAVAAVEARCGRVSLVLKADVRAGQSGRLDAKVATVERHLAP
>NC_013595.1|WP_012890562.1|4346973_4348089_+|MBL-fold-metallo-hydrolase
MAGNGSIGRVLVGGLALAAAGWALKDIPAELGGRATGERLARMLRSPRFHDGVFHNPVPGSYTPPVSSVPAMLRELIFDRDGRKPGGPIPLVTSPATPPSAGGLSVVWYGHATTLVEIEGRRVLFDPVWSERASPSRLVGPRRLHPLPAPLADLPVLDAIVISHDHYDHLDRATVRALTALQSAPFLVPLGIGAHLERWGVPASRIVELDWEEEATVAGLRFVATAARHFSGRALTRNTTLWGSWVVAGRTRRVFYAGDSGYFDGYAGIGAAHGPFDLTLMPIGAYSPAWPDIHMDPEEAIDAHLDLGGRLLLPVHWATFTLAVHPWAEPVDRLRHEAKARGVRLAVPRPGDRVDTDDVPLLDGWWELLGI
>NC_013595.1|WP_012890563.1|4348104_4348881_-|nucleotidyltransferase-domain-containing-protein
MTVTLPAWLAEIPAEQAAPPAFVTVSGAHLYGFPSADSDVDLRGVHVLPLEQVVGLRTGEETVTRSWTRHGVEVDLVTHDLAKFCHLLLRRNGYVLEQLLSPLVVATSPVHREMVAAAPGCLTRHHAHHYLGFARTQWRLFERSGELKPLLYTFRVLLTGIHLMRTGLLVADLTLLTGLVAGAPPYLADLMAAKRSAEHGPTPPGAPGAVRLAHDVARLTAELEEARDASHLPDAATSAGVLNDLVVRTRLSARASRA

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Crispr_ID: NC_013595_28

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_28

4468351-4468470

Orphan

Consensus_repeat	Method
GGCCGCGCGGCTCTCCCGGGCCTTCCTGGGTGGCCGGCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_28

>merge|NC_013595|28|4468351-4468470|CRISPRCasFinder
GGCCGCGCGGCTCTCCCGGGCCTTCCTGGGTGGCCGGCTCTCCCGGGCTGTCCTGGCCGCTCTGCTCTTTCGGCCTTCCTGGCCGCGCGGCTCTCCCGGGCCTTCCCGGGTGGCCGGCTC

>NC_013595|28|26|4468351-4468470|CRISPRCasFinder
GGCCGCGCGGCTCTCCCGGGCCTTCCTGGGTGGCCGGCTC	TCCCGGGCTGTCCTGGCCGCTCTGCTCTTTCGGCCTTCCT
GGCCGCGCGGCTCTCCCGGGCCTTCCCGGGTGGCCGGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012890665.1\|4469274_4469589_+\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|171110
NC_013595.1\|WP_012890659.1\|4465434_4465812_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012890655.1\|4460774_4461395_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133380
NC_013595.1\|WP_012890671.1\|4475458_4475971_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|184218
NC_013595.1\|WP_012890669.1\|4472938_4474594_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	unknown	unknown	gnl\|CDD\|236020
NC_013595.1\|WP_086012361.1\|4460159_4460630_+\|bifunctional-nuclease-family-protein	unknown	unknown	gnl\|CDD\|376830
NC_013595.1\|WP_043656109.1\|4465903_4466500_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|226101
NC_013595.1\|WP_012890661.1\|4466503_4466695_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_148269133.1\|4467114_4467711_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|172294
NC_013595.1\|WP_012890672.1\|4476413_4478315_+\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NC_013595.1\|WP_012890667.1\|4471217_4471604_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012890668.1\|4471654_4472830_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236108
NC_013595.1\|WP_012890663.1\|4467853_4468255_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236368
NC_013595.1\|WP_012890664.1\|4468621_4469278_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224103
NC_013595.1\|WP_012890658.1\|4464638_4465421_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370767
NC_013595.1\|WP_012890666.1\|4469673_4471032_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|235640
NC_013595.1\|WP_012890670.1\|4474744_4475380_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NC_013595.1\|WP_012890653.1\|4459402_4460080_+\|MerR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133378
NC_013595.1\|WP_012890657.1\|4461661_4464517_+\|aminomethyl-transferring-glycine-dehydrogenase	unknown	unknown	gnl\|CDD\|235432
NC_013595.1\|WP_081453437.1\|4475967_4476189_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367272

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_043656109.1\|4465903_4466500_+\|alpha/beta-hydrolase	gnl\|CDD\|226101	COG3571, COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only].	2.7771e-19
NC_013595.1\|WP_012890666.1\|4469673_4471032_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	2.62038e-156
NC_013595.1\|WP_012890655.1\|4460774_4461395_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133380	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators. Helix-turn-helix (HTH) transcription regulator GlnR and related proteins, N-terminal domain. The GlnR and TnrA (also known as ScgR) proteins have been shown to regulate expression of glutamine synthetase as well as several genes involved in nitrogen metabolism. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	1.83248e-18
NC_013595.1\|WP_012890671.1\|4475458_4475971_+\|hypothetical-protein	gnl\|CDD\|184218	PRK13661, PRK13661, ECF-type riboflavin transporter substrate-binding protein.	0.00835573
NC_013595.1\|WP_086012361.1\|4460159_4460630_+\|bifunctional-nuclease-family-protein	gnl\|CDD\|376830	pfam02577, DNase-RNase, Bifunctional nuclease. This family is a bifunctional nuclease, with both DNase and RNase activity. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site.	9.37704e-59
NC_013595.1\|WP_012890665.1\|4469274_4469589_+\|multidrug-efflux-SMR-transporter	gnl\|CDD\|171110	PRK11431, PRK11431, quaternary ammonium compound efflux SMR transporter SugE.	2.57113e-23
NC_013595.1\|WP_012890669.1\|4472938_4474594_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	gnl\|CDD\|236020	PRK07449, PRK07449, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Validated.	0
NC_013595.1\|WP_148269133.1\|4467114_4467711_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	gnl\|CDD\|172294	PRK13756, PRK13756, TetR family transcriptional regulator.	1.94668e-13
NC_013595.1\|WP_012890672.1\|4476413_4478315_+\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NC_013595.1\|WP_012890668.1\|4471654_4472830_-\|AMP-binding-protein	gnl\|CDD\|236108	PRK07824, PRK07824, o-succinylbenzoate--CoA ligase.	5.37742e-99
NC_013595.1\|WP_012890663.1\|4467853_4468255_+\|hypothetical-protein	gnl\|CDD\|236368	PRK09058, PRK09058, heme anaerobic degradation radical SAM methyltransferase ChuW/HutW.	0.00484529
NC_013595.1\|WP_012890664.1\|4468621_4469278_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|224103	COG1182, AcpD, Acyl carrier protein phosphodiesterase [Lipid metabolism].	2.73143e-46
NC_013595.1\|WP_012890658.1\|4464638_4465421_+\|hypothetical-protein	gnl\|CDD\|370767	pfam09976, TPR_21, Tetratricopeptide repeat-like domain. This family resembles a single unit of a TPR repeat.	0.000185858
NC_013595.1\|WP_012890670.1\|4474744_4475380_+\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	5.06012e-42
NC_013595.1\|WP_012890653.1\|4459402_4460080_+\|MerR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	4.26896e-16
NC_013595.1\|WP_012890657.1\|4461661_4464517_+\|aminomethyl-transferring-glycine-dehydrogenase	gnl\|CDD\|235432	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase.	0
NC_013595.1\|WP_081453437.1\|4475967_4476189_-\|hypothetical-protein	gnl\|CDD\|367272	pfam02956, TT_ORF1, TT viral orf 1. TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF1 is a large 750 residue protein. The N-terminal half of this protein corresponds to the capsid protein.	7.84695e-07

>NC_013595.1|WP_012890663.1|4467853_4468255_+|hypothetical-protein
MAFFRPSVSREAEVRYHADQEVGKSFPELLEKARAAEAELRRVQATSTSAEERRAAGRAFDAALTEALRAAEANQRATFGVKSYDDRIRRRKGRATPKGAEWTAEVNRLRTLREQNRLTGIARVPRPVALAAR
>NC_013595.1|WP_148269133.1|4467114_4467711_-|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein
MSPMPAKRPPIPLSRERIIEAALHIADSQGLRRLTMRRLGDALQVEAMAIYHHLPRGKDALMDALAEHVTTVHAEPGESWQDSARAWCRASRAALREHPGVLALALTKPPKGRAAIAVREQTDQLADAGLADAARAVRAMRAYVFGAVAVEVQQSGWAEPAGDDDEPWRPPSRGGGSAAADDDFELGLSALLAGLDGA
>NC_013595.1|WP_012890661.1|4466503_4466695_-|hypothetical-protein
MCPHQPSCPSAEALDREAARTMAAHPEQGWSLLCNGVVLFEDTGELLPDGAVIEPHRPLAGVA
>NC_013595.1|WP_043656109.1|4465903_4466500_+|alpha/beta-hydrolase
MTPHGPAVAEVDEVADPRFLLVITHGSAGGVDAPDLLAVRDATAGVGGVVARVLQPFRLRGARAPGSAVKQDEAWTALVAELRGRYPGLPLAQGGRSNGARVACRTALGVGAEAVVALAFPLHPPGRPERSRAGELRAAGVDVLVVNGDRDPFGVPGAADAARLVVLPGEGHDLKKDPARVGEVVAEWLEVRMRPGSA
>NC_013595.1|WP_012890659.1|4465434_4465812_-|hypothetical-protein
MQDHQDIRQDMRATIEARRDLGPEYESALVESFVERLDATIAARVRTEMHLAGGPPPYPGPHEQGRRQRRSGNSSVPIALGSMGIGIPLTAIAAGEAGTAGLLLAWGGIVAINFAHAISRWRGRD
>NC_013595.1|WP_012890658.1|4464638_4465421_+|hypothetical-protein
MPEVDTHPLDTARKLAESGDLDGAAKIFAELAADPAEPDRAQAAVGLAVVLQERGDAPGARTAARTALATGHPEFAAQAACLLARSFEQEDLLDQARAAWQAALGAGNPAYVPLAHMALARLAAGQQEAEEALRAALATADPEVASRAAQLLAELLLEEGEAGEAAEALLAALSVPEVADAPRLRVLLGIAHLEMACAEFAGAIEEGGDAETAALAIELLARTLPLRGRDEDAEQVWRYGLDSADGELAEDVRLRLNRGA
>NC_013595.1|WP_012890657.1|4461661_4464517_+|aminomethyl-transferring-glycine-dehydrogenase
MTDLSPLSELISPPFATRHIGPADADQTRMLEAVGFASTADLVAVTVPEAIRAKDRLRLPPAASETEALAELRALAARNSVLTSMIGLGYHDTITPGVIRRNLLENPGWYTAYTPYQPEISQGRLEALINFQTVVSDLTALDVAGASLLDEATAAAEAMTLARRAGRAKSDVFVVDADALPQTKAVLRTRAEPLGIELVESDFTAELPECFGVLVQYPGASGRVRDFRSIADAAHARGAQVVAAADLLALTLLAAPGEFGADIAIGSSQRFGVPLGFGGPHAAYMAVRDGLQRQMPGRLVGVSQDADLRPAYRLALQTREQHIRREKATSNICTAQVLLAVIAGMYAVYHGPEGLRRIGRRIHRHAVVLAEGLRHGGVEVVHDTFFDTVLARVPGRAAEVVAAARDNGVNLRLVDADHVGVTCDEKTELLHLEQVLAAFEVSGAVLTDLDAAAHDALPAALARVSDYLTHPVFHSHRSETSMLRYLRRLQDKDIALDRSMIPLGSCTMKLNATTEMEPITWPEFAGLHPYAPEEQAAGYLELIKELEGWLAEVTGYDAVSIQPNAGSQGEFAGLLAIRAYHKARGESGRDVCLIPSSAHGTNAASAVMAGMRVAVVACDDEGNVDLDDLNAKIDKHRGQLAAIMVTYPSTHGVYEETITQICERVHEAGGQVYVDGANLNALVGLAKPGEFGADVSHLNLHKTFCIPHGGGGPGVGPVAVRAHLADYLPGHPLREGSAVGPVSAAPYGSAGILPISWAYIRMMGTEGLTAATEQAILSANYLARRLAPHYPVLYTGRGGLVAHECIVDLRQITKETGVTVDDVAKRLVDYGFHAPTMSFPVAGTLMIEPTESEDLAELDRFCDAMIAIRGEIGKVASGAYDRVDNPLRNAPHTADCLVADEWAHPYTRTEAAYPLPSVREGKYWSPVRRIDQAYGDRNLVCSCPPLEAYED
>NC_013595.1|WP_012890655.1|4460774_4461395_+|MerR-family-transcriptional-regulator
MAVSSGEGRNADQDDPERRQSARQRAGEEGLLFDGQPVKAPADIGYRGPTACAAADITYRQLDYWARTGLVEPTVRAAHGSGSQRLYGFRDILVLKVVKRLLDTGVSLQQIRIAVQHLRDRGVNDLAQITLMSDGVSVYECTSPDEVIDLLQGGQGVFGIALGRVWQEVEGSLADLPGERAESGQGPLDDHHADELARRRRARRTG
>NC_013595.1|WP_086012361.1|4460159_4460630_+|bifunctional-nuclease-family-protein
MLQMEVVGVRVEMPSNQPIVLLKEAHGERYLPIWIGMTEATAIAMAQAEEPPPRPLTHDLFRDVLDALGVRLSTVNIVALRDGIFFADLVFSNGVEVSARPSDSIALALRTGARIFASEDVVREAGVIIPDDQEDEVEKFREFLDTITPEDFGRAG
>NC_013595.1|WP_012890653.1|4459402_4460080_+|MerR-family-DNA-binding-transcriptional-regulator
MSSQAARAHMSIGEVLALLQGEFPDVSISKIRFLEGEGLIEPERSPSGYRKFTYADVERLRYILSEQRDRYLPLRVIKDQLEAADREERPVARPRAVPDDAPPEVRLTREELLAAAELNEETLAELEDYGLLAAVARYYDAEALAVARSVGALAAFGLHARHLRAVKAAAEREAGLVEQAIAPLLRRRGPGAIDRADETAREISGLLLELHASLLRSGVRGVLGR
>NC_013595.1|WP_012890664.1|4468621_4469278_+|NAD(P)H-dependent-oxidoreductase
MSHLLHLDASARRASFSRTLSEAFARTWREADPDGAYVYRDLAAAPVPHVGEAWTELCYAVLAEGITEIGRYREVVRTPAQEDAWAIVEPLLAELEAADVVLIGTPMYNYSVPSALKAWIDQVTFPKMSLKGRSFVVAGARGGAYGPGTPREAFDHEERFLRDFFLGHFGVEDVTFIHAELTNSLIDPALAGLRDKHEKSYEAALEAAAELGGKLAGR
>NC_013595.1|WP_012890665.1|4469274_4469589_+|multidrug-efflux-SMR-transporter
MSWVLLVLAGLVEIAWSQSIKPTEGFTRPIPTVICFALAAVAVWLLSKSMQTLPVGTAYAVFTGIGAVGAIGLGIALHGDPVNLGRVAALALIIGGIVLARALG
>NC_013595.1|WP_012890666.1|4469673_4471032_-|RNA-polymerase-sigma-factor
MPQTAVATSPEAPTTLEQLLDRGRVQGHLSLAELRHAFAEAGISPTEGRSILRELTEAGVSLAAENEPALAAGAKKPAAKSTARKTTTRKTKAASDKTAAPENNKSTVRAEPAAKDRKDAGPEAGDEEWTAPEEAELEAEPTLDLDDQSSVMGDSVHTYLKSIGRRTLLTAAQEVELAKRIEAGLYAESKLEAEPGLSAAARDDLEWVAEDGRRAKDHMLEANLRLVVSVAKKYTDRGMALLDVVQEGNLGLIRAVEKFDYTKGYKFSTYAMWWIRQAIQRGFADSARTIRLPVHVLEMLSKLSRVERDMHQRLGREPTPEELAVELDKTPDQIEELLRTSRQPISLNATIGEDGETTIGDLIEDVDSPEASEVVDRQLLGEQLRGVLGNLSPREAKIMALRFGLVDGKPHTLDEIGKHLGLTRERIRQLEKESLSKLRHPSNTRPLLDWAS
>NC_013595.1|WP_012890667.1|4471217_4471604_-|hypothetical-protein
MNVTRKTWVSAGIVSVVLAGGISVAAAAATGGISKNGEPVPAVKGGQPLPEGARASQDPPDLSAGPEGDTPAQEDPSQGATPPAEEYVVSKEVNPDPQQVTRYWTEQRLEDAQPLPMPVVEGPVDITE
>NC_013595.1|WP_012890668.1|4471654_4472830_-|AMP-binding-protein
MTGSAHPEQPCPRRELHAVVLPPGPELFRAVGAALDGRGPAVLPLSPALPTRALRATLDALRPTHVNGVRHEHGVGVSPEVAVVIATSGTTGTPKGVQLPAAALRASASASLRRLDARPGERWLCCLPPSHVSGLQVLVRSLLSETEPIVHDGFSPEAVLASGADHVSLVPTQLRRLLPADLSVFRTILLGGAAAPADLLAAARAAGARVVTTYGMSETCGGCVYDGVPLDGVDLGVGDDGRVRVAGPVLFSGYRLRPDLTAAARDGDWFLTSDLGSLAGGRLRVLGRADDVINTGGEKVVAAAVAAVVAEHPAVADAAVVGRPDPEWGERVVAVVVSSEPPTLAELRAFAKERLPAYAAPAELVVMSEIPLLPNGKPDLATLRYGLQREP
>NC_013595.1|WP_012890669.1|4472938_4474594_+|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase
MNPATALATVLIDELVRCGLTDVVLAPGSRSAPLALAVHADSRIRLHVRVDERSASFLALGLARRGERPVALICTSGTAAANFHPAVIEAHESGVPLLLLTADRPPELRDTGASQTIDQIKLYGTAVRWFSEVGLPEDRPGQVAYWRSLACRAYQRSLGPTDPGPVQLNLSFREPLIPDGDASWCESLEGDANGPWIRARVAPPAVALHLPPTRRGVLVVGDGASNVRRYVAAAGMAGWPVLSEPNGGARYGDHAMSTYHFLLGTPEFADRHRPELVVTLGRPGLSRSLLNWLRHADEHIVVAPDLTRWPDPTRSATQVAQAVEIPVAAGDDAWLHSWRRADNAARAAIDEVLDGAGLSEPRLARDLVDMLPNGSLLFSGSSMPIRDLDQAMRPRRGLRILANRGTAGIDGVVSTAMGAALAHNGPAYALMGDLTFLHDQNGLILGPREPRPDLCVVVVNNDGGGIFSLLPQAALRDPFERVFGTAHGVDLAHVAAATGTPYTFVSEPDQLSKALRGEGLRIVEVRSDRESNAVLHAMMRDAAHAAIREVM
>NC_013595.1|WP_012890670.1|4474744_4475380_+|DedA-family-protein
MHVDEWLQAIPPLWICALVGLVIGLESLGIPLPGEIVLVSSALLAAQGVVNPLWVGICASVGAIVGDSVGYAIGRKGGKPMFDRLGRRFPKHFGPSHIAKAERYFERYGMWTVFFGRFVALLRILAGPLAGALRMPYWRFLTANVLGGIAWAGGTTAVVYYLGRVAEKWLKGFSWAGLVLAVLFGVATTLLVKRRAARMVAQEAEEPAGAV
>NC_013595.1|WP_012890671.1|4475458_4475971_+|hypothetical-protein
MRTDDTSIAYEPVASYNTYLEAQKAVDYLSDQKFPVEHAKIVGTDLRLVEKVLGRLTYLRAAGMGAATGAWIGLLIGLFLAIFTPGRFPFLLVLWALVWGAIAGAIFGLIGHALTGGKRDFLSSSSIVANRYQVLVTTDRAAEARRLLEVGTPQAAQVPQTPQTPHTPQF
>NC_013595.1|WP_081453437.1|4475967_4476189_-|hypothetical-protein
MEALSRRGPVPLEPRRARGPHGRRGRRSRDGQRGRRGRDGRRGRDGRRGRDGRRGRDGRRGRDGRRGRRGPSR
>NC_013595.1|WP_012890672.1|4476413_4478315_+|molecular-chaperone-DnaK
MARAVGIDLGTTNSVIATMEGSQPTVIPNAEGSRTTPSVVAFTEQGERLVGQLARRQAILNPKGTIYSAKRFIGRRFDEVTSEMNAVSFDVVPGPDGAVRFDVHGKLYAPEEIAAQVLRKLVDDASKFLGEKITEAVITVPAYFNDSQRQATKDAGKIAGLEVLRIVNEPTAAALAYGMDRKENETVLVFDLGGGTFDVSILTIGDGVVEVRSTSGDTHLGGDDFDRRIVDYLADEFQRDNGIDLRNDPQALQRLFEAAEKAKVELSSVTQTQISLPFITADASGPKHLNTTLRRATFEEMTADLLERCKGPVEQAIADAKLSSNDIDEVILVGGSTRMPAVQNLVRRMTGGKDPNMTVNPDEVVALGAAVQAAVIKGELQDVVLLDVTPLSLGIETLGGIMTKVIERNTTIPARRTEVFSTAEDNQSAVDVVVLQGERERAADNRALGRFRLENIRSAPRGEPQVEVTFDVDANGIVNVSARDKDTNAEQRITISESSNLDQSEVERMVSDAEQHREEDVRLRQAVDARNELDSAAYQVERRLNELGEAVPVHEKARAEMLVNDARDAVKQQDTPVDRLRSLTSELQQVYQSLAVASAGQPAGAGPGAQGSQDARGGGGDDDVIDAEFTTDE

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Crispr_ID: NC_013595_29

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_29

4475918-4476134

Orphan

Consensus_repeat	Method
CCGACCGCGCCGGCCGTCCCGAC	CRISPRCasFinder

4 spacers

The CRISPR arrays of NC_013595_29

>merge|NC_013595|29|4475918-4476134|CRISPRCasFinder
CAGGCCGCGCAGGTCCCCCAGACTCCGCAGACCCCGCACACTCCGCAGTTCTAGCGGGACGGTCCGCGCCGACCGCGCCGGCCGTCCCGACCGCGCCGGCCGTCCCGACCGCGCCGGCCGTCCCGACCGCGCCGGCCGTCCCGACCGCGCCGGCCGTCCCGACCGCGCCGACCGCGCTGGCCGTCCCGACTGCGTCGGCCGCGACGGCCGTGCGGTC

>NC_013595|29|27|4475918-4476134|CRISPRCasFinder
CAGGCCGCGCAGGTCCCCCAGAC	TCCGCAGACCCCGCACACTCCGCAGTTCTAGCGGGA
CGGTCCGCGCCGACCGCGCCGGC	CGTCCCGACCGCGCCGGCCGTC
CCGACCGCGCCGGCCGTCCCGAC	CGCGCCGGCCGTCCCGACCGCG
CCGGCCGTCCCGACCGCGCCGAC	CGCGCTGGCCGTCCCGACTGCG
TCGGCCGCGACGGCCGTGCGGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012890675.1\|4479887_4480208_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|338835
NC_013595.1\|WP_012890677.1\|4482817_4483264_+\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NC_013595.1\|WP_012890670.1\|4474744_4475380_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NC_013595.1\|WP_012890666.1\|4469673_4471032_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|235640
NC_013595.1\|WP_148269133.1\|4467114_4467711_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|172294
NC_013595.1\|WP_012890676.1\|4480198_4482805_+\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529
NC_013595.1\|WP_012890674.1\|4478837_4479788_+\|DnaJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|237667
NC_013595.1\|WP_012890661.1\|4466503_4466695_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012890665.1\|4469274_4469589_+\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|171110
NC_013595.1\|WP_012890669.1\|4472938_4474594_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	unknown	unknown	gnl\|CDD\|236020
NC_013595.1\|WP_012890681.1\|4488296_4489619_+\|lantibiotic-modifying-protein	unknown	unknown	gnl\|CDD\|271198
NC_013595.1\|WP_012890672.1\|4476413_4478315_+\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NC_013595.1\|WP_012890673.1\|4478307_4478838_+\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|271355
NC_013595.1\|WP_012890667.1\|4471217_4471604_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012890668.1\|4471654_4472830_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236108
NC_013595.1\|WP_012890663.1\|4467853_4468255_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236368
NC_013595.1\|WP_012890664.1\|4468621_4469278_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224103
NC_013595.1\|WP_012890680.1\|4487326_4488067_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_013595.1\|WP_043652383.1\|4484875_4487125_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226415
NC_013595.1\|WP_012890678.1\|4483265_4484882_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|273540

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012890675.1\|4479887_4480208_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|338835	pfam13591, MerR_2, MerR HTH family regulatory protein.	1.10211e-08
NC_013595.1\|WP_012890677.1\|4482817_4483264_+\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	2.10587e-36
NC_013595.1\|WP_012890665.1\|4469274_4469589_+\|multidrug-efflux-SMR-transporter	gnl\|CDD\|171110	PRK11431, PRK11431, quaternary ammonium compound efflux SMR transporter SugE.	2.57113e-23
NC_013595.1\|WP_012890666.1\|4469673_4471032_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	2.62038e-156
NC_013595.1\|WP_148269133.1\|4467114_4467711_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	gnl\|CDD\|172294	PRK13756, PRK13756, TetR family transcriptional regulator.	1.94668e-13
NC_013595.1\|WP_012890676.1\|4480198_4482805_+\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NC_013595.1\|WP_012890674.1\|4478837_4479788_+\|DnaJ-domain-containing-protein	gnl\|CDD\|237667	PRK14299, PRK14299, chaperone protein DnaJ; Provisional.	1.40555e-75
NC_013595.1\|WP_012890670.1\|4474744_4475380_+\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	5.06012e-42
NC_013595.1\|WP_012890669.1\|4472938_4474594_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	gnl\|CDD\|236020	PRK07449, PRK07449, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Validated.	0
NC_013595.1\|WP_012890672.1\|4476413_4478315_+\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NC_013595.1\|WP_012890673.1\|4478307_4478838_+\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|271355	cd00446, GrpE, nucleotide exchange factor GrpE. GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.	1.74732e-42
NC_013595.1\|WP_012890681.1\|4488296_4489619_+\|lantibiotic-modifying-protein	gnl\|CDD\|271198	cd04434, LanC_like, Cyclases involved in the biosynthesis of lantibiotics, and similar proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain thioether cross-links called lanthionines (Lans) or methyllanthionines (MeLans), in addition to 2,3-didehydroalanine (Dha) and (Z)-2,3-didehydrobutyrine (Dhb). These unusual amino acids are introduced by the dehydration of serine and threonine residues, followed by thioether formation via addition of cysteine thiols, catalysed by LanB and LanC or LanM. LanC, the cyclase component, is a zinc metalloprotein, whose bound metal has been proposed to activate the thiol substrate for nucleophilic addition. A related domain is also present in LanM and other pro- and eukaryotic proteins with poorly characterized functions.	4.71855e-93
NC_013595.1\|WP_012890668.1\|4471654_4472830_-\|AMP-binding-protein	gnl\|CDD\|236108	PRK07824, PRK07824, o-succinylbenzoate--CoA ligase.	5.37742e-99
NC_013595.1\|WP_012890663.1\|4467853_4468255_+\|hypothetical-protein	gnl\|CDD\|236368	PRK09058, PRK09058, heme anaerobic degradation radical SAM methyltransferase ChuW/HutW.	0.00484529
NC_013595.1\|WP_012890664.1\|4468621_4469278_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|224103	COG1182, AcpD, Acyl carrier protein phosphodiesterase [Lipid metabolism].	2.73143e-46
NC_013595.1\|WP_012890680.1\|4487326_4488067_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	2.37029e-66
NC_013595.1\|WP_043652383.1\|4484875_4487125_-\|AAA-family-ATPase	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	2.77934e-21
NC_013595.1\|WP_012890678.1\|4483265_4484882_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.9851e-82

>NC_013595.1|WP_012890670.1|4474744_4475380_+|DedA-family-protein
MHVDEWLQAIPPLWICALVGLVIGLESLGIPLPGEIVLVSSALLAAQGVVNPLWVGICASVGAIVGDSVGYAIGRKGGKPMFDRLGRRFPKHFGPSHIAKAERYFERYGMWTVFFGRFVALLRILAGPLAGALRMPYWRFLTANVLGGIAWAGGTTAVVYYLGRVAEKWLKGFSWAGLVLAVLFGVATTLLVKRRAARMVAQEAEEPAGAV
>NC_013595.1|WP_012890669.1|4472938_4474594_+|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase
MNPATALATVLIDELVRCGLTDVVLAPGSRSAPLALAVHADSRIRLHVRVDERSASFLALGLARRGERPVALICTSGTAAANFHPAVIEAHESGVPLLLLTADRPPELRDTGASQTIDQIKLYGTAVRWFSEVGLPEDRPGQVAYWRSLACRAYQRSLGPTDPGPVQLNLSFREPLIPDGDASWCESLEGDANGPWIRARVAPPAVALHLPPTRRGVLVVGDGASNVRRYVAAAGMAGWPVLSEPNGGARYGDHAMSTYHFLLGTPEFADRHRPELVVTLGRPGLSRSLLNWLRHADEHIVVAPDLTRWPDPTRSATQVAQAVEIPVAAGDDAWLHSWRRADNAARAAIDEVLDGAGLSEPRLARDLVDMLPNGSLLFSGSSMPIRDLDQAMRPRRGLRILANRGTAGIDGVVSTAMGAALAHNGPAYALMGDLTFLHDQNGLILGPREPRPDLCVVVVNNDGGGIFSLLPQAALRDPFERVFGTAHGVDLAHVAAATGTPYTFVSEPDQLSKALRGEGLRIVEVRSDRESNAVLHAMMRDAAHAAIREVM
>NC_013595.1|WP_012890668.1|4471654_4472830_-|AMP-binding-protein
MTGSAHPEQPCPRRELHAVVLPPGPELFRAVGAALDGRGPAVLPLSPALPTRALRATLDALRPTHVNGVRHEHGVGVSPEVAVVIATSGTTGTPKGVQLPAAALRASASASLRRLDARPGERWLCCLPPSHVSGLQVLVRSLLSETEPIVHDGFSPEAVLASGADHVSLVPTQLRRLLPADLSVFRTILLGGAAAPADLLAAARAAGARVVTTYGMSETCGGCVYDGVPLDGVDLGVGDDGRVRVAGPVLFSGYRLRPDLTAAARDGDWFLTSDLGSLAGGRLRVLGRADDVINTGGEKVVAAAVAAVVAEHPAVADAAVVGRPDPEWGERVVAVVVSSEPPTLAELRAFAKERLPAYAAPAELVVMSEIPLLPNGKPDLATLRYGLQREP
>NC_013595.1|WP_012890667.1|4471217_4471604_-|hypothetical-protein
MNVTRKTWVSAGIVSVVLAGGISVAAAAATGGISKNGEPVPAVKGGQPLPEGARASQDPPDLSAGPEGDTPAQEDPSQGATPPAEEYVVSKEVNPDPQQVTRYWTEQRLEDAQPLPMPVVEGPVDITE
>NC_013595.1|WP_012890666.1|4469673_4471032_-|RNA-polymerase-sigma-factor
MPQTAVATSPEAPTTLEQLLDRGRVQGHLSLAELRHAFAEAGISPTEGRSILRELTEAGVSLAAENEPALAAGAKKPAAKSTARKTTTRKTKAASDKTAAPENNKSTVRAEPAAKDRKDAGPEAGDEEWTAPEEAELEAEPTLDLDDQSSVMGDSVHTYLKSIGRRTLLTAAQEVELAKRIEAGLYAESKLEAEPGLSAAARDDLEWVAEDGRRAKDHMLEANLRLVVSVAKKYTDRGMALLDVVQEGNLGLIRAVEKFDYTKGYKFSTYAMWWIRQAIQRGFADSARTIRLPVHVLEMLSKLSRVERDMHQRLGREPTPEELAVELDKTPDQIEELLRTSRQPISLNATIGEDGETTIGDLIEDVDSPEASEVVDRQLLGEQLRGVLGNLSPREAKIMALRFGLVDGKPHTLDEIGKHLGLTRERIRQLEKESLSKLRHPSNTRPLLDWAS
>NC_013595.1|WP_012890665.1|4469274_4469589_+|multidrug-efflux-SMR-transporter
MSWVLLVLAGLVEIAWSQSIKPTEGFTRPIPTVICFALAAVAVWLLSKSMQTLPVGTAYAVFTGIGAVGAIGLGIALHGDPVNLGRVAALALIIGGIVLARALG
>NC_013595.1|WP_012890664.1|4468621_4469278_+|NAD(P)H-dependent-oxidoreductase
MSHLLHLDASARRASFSRTLSEAFARTWREADPDGAYVYRDLAAAPVPHVGEAWTELCYAVLAEGITEIGRYREVVRTPAQEDAWAIVEPLLAELEAADVVLIGTPMYNYSVPSALKAWIDQVTFPKMSLKGRSFVVAGARGGAYGPGTPREAFDHEERFLRDFFLGHFGVEDVTFIHAELTNSLIDPALAGLRDKHEKSYEAALEAAAELGGKLAGR
>NC_013595.1|WP_012890663.1|4467853_4468255_+|hypothetical-protein
MAFFRPSVSREAEVRYHADQEVGKSFPELLEKARAAEAELRRVQATSTSAEERRAAGRAFDAALTEALRAAEANQRATFGVKSYDDRIRRRKGRATPKGAEWTAEVNRLRTLREQNRLTGIARVPRPVALAAR
>NC_013595.1|WP_148269133.1|4467114_4467711_-|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein
MSPMPAKRPPIPLSRERIIEAALHIADSQGLRRLTMRRLGDALQVEAMAIYHHLPRGKDALMDALAEHVTTVHAEPGESWQDSARAWCRASRAALREHPGVLALALTKPPKGRAAIAVREQTDQLADAGLADAARAVRAMRAYVFGAVAVEVQQSGWAEPAGDDDEPWRPPSRGGGSAAADDDFELGLSALLAGLDGA
>NC_013595.1|WP_012890661.1|4466503_4466695_-|hypothetical-protein
MCPHQPSCPSAEALDREAARTMAAHPEQGWSLLCNGVVLFEDTGELLPDGAVIEPHRPLAGVA
>NC_013595.1|WP_012890672.1|4476413_4478315_+|molecular-chaperone-DnaK
MARAVGIDLGTTNSVIATMEGSQPTVIPNAEGSRTTPSVVAFTEQGERLVGQLARRQAILNPKGTIYSAKRFIGRRFDEVTSEMNAVSFDVVPGPDGAVRFDVHGKLYAPEEIAAQVLRKLVDDASKFLGEKITEAVITVPAYFNDSQRQATKDAGKIAGLEVLRIVNEPTAAALAYGMDRKENETVLVFDLGGGTFDVSILTIGDGVVEVRSTSGDTHLGGDDFDRRIVDYLADEFQRDNGIDLRNDPQALQRLFEAAEKAKVELSSVTQTQISLPFITADASGPKHLNTTLRRATFEEMTADLLERCKGPVEQAIADAKLSSNDIDEVILVGGSTRMPAVQNLVRRMTGGKDPNMTVNPDEVVALGAAVQAAVIKGELQDVVLLDVTPLSLGIETLGGIMTKVIERNTTIPARRTEVFSTAEDNQSAVDVVVLQGERERAADNRALGRFRLENIRSAPRGEPQVEVTFDVDANGIVNVSARDKDTNAEQRITISESSNLDQSEVERMVSDAEQHREEDVRLRQAVDARNELDSAAYQVERRLNELGEAVPVHEKARAEMLVNDARDAVKQQDTPVDRLRSLTSELQQVYQSLAVASAGQPAGAGPGAQGSQDARGGGGDDDVIDAEFTTDE
>NC_013595.1|WP_012890673.1|4478307_4478838_+|nucleotide-exchange-factor-GrpE
MSDASEREPMSDASEREETVPEGAEGAPADVAELQQRIIELEDRWRRALADLDNLRKRVSRDAERVRAEERARAAAEWLPVLDNLERALEHAESDPPSIIEGLRAIRDQAQDVLARLGFPRRDDAGTAFDPARHEAVATLAQEGVPEGTVLHVVRPAYGDGDRQLRPALVVVAREG
>NC_013595.1|WP_012890674.1|4478837_4479788_+|DnaJ-domain-containing-protein
MATTTRDFYESLGVSRDAGQDEIQSAYRKLARTYHPDVNKDPGAEDRFKEISEAYSVLSDPATRRRYDAFGPDFRQVPEDVDPDTWARARAGRGARGRRPGAGAGAGPGGPAGFGEGVDFEDLLEGLFSGRGGGRAGRGWGPIPGADQEAEIELTVEEAYRGGRRSITVGGRRIDVNIPAGVTDGQRIRLAGQGGRGSDGAAAGDLYLIVRIAPHPRYRVEGRDIRVQLPVTPWEAALGASVAVDTPAGEAKVKVPAGSSSGRRLRLRGRGMPNPRGTPGDLFAEVRIMVPAALSDEERRLFEQLAAVSTFDPRRR
>NC_013595.1|WP_012890675.1|4479887_4480208_+|MerR-family-transcriptional-regulator
MIYALVRPARLDLEAFARATGTHPDLVRRLVALGVLDAQRDAAGALWFPPAQLYAMARIQRLRAGFGLNYAALGLVVDLLDRIAELEAAQRDRSRITGIPGGPQWT
>NC_013595.1|WP_012890676.1|4480198_4482805_+|ATP-dependent-chaperone-ClpB
MDVNQLTQKSQEALHDAQTKALRFGHTEIDGEHLLLALLDQPDGLIPRLLTKADVDLDRLVADLEAELSRRPKVSGPGVDPGQVRVTQRLSRLLETAKREADRLKDDYVSVEHLLVALLEEGSETSAGRLLRQQGLSRDAFLRVLTEIRGNQRVTSAMPEVAYEALAKYGRDLVADAAAGKLDPVIGRDSEIRRVIQILSRKSKNNPVLVGDPGVGKTAIVEGLAQRINNGDVPDGLKDKTVFSLDMGALVAGAKYRGEFEERLKAVLTEVVAAEGRILLFVDELHTVVGAGAAEGAMDAGNMLKPMLARGELHMIGATTLEEYRRHIEKDAALERRFQPVMVDEPSVEDAISILRGLRERLEVFHGVTIQDGALVAAVVLSHRYISDRFLPDKAIDLVDEACAMLRTEIDSMPAELDELTRRVMRLEIEEAALAKEEDQASRARLEELRKELADLRAEADAMRAQWEAERQVLRGVQTLREEIERVRTEAERAERDYDLNRAAELRHGKLPELERRLQAEEERLLAKQGAGRLLREVVTEEEIAMIVSRWTGIPVSRLQEGEREKLLHLDEILHERVIGQDEAVRLVADAVIRARSGIKDPRRPIGSFIFLGPTGVGKTELAKALAAALFDTEDNMIRIDMSEYQERHTVSRLVGAPPGYVGYDEGGQLTEAVRRKPYSVVLFDEVEKAHPDVFNTLLQVLDDGRLTDAQGRTVDFRNTVLIMTSNIGSIYLLEGVTPSGEIKHDVQEQVMAELRSHFRPEFLNRVDDIVIFKPLTPQEIEHIVELMFGELRARLDERGIGLEVSEDARRYIAERGYDPVYGARPLRRFIAREVETRIGRALLTGDVHEGAVVRVGLAEGELVVTYE
>NC_013595.1|WP_012890677.1|4482817_4483264_+|thioredoxin
MSSNILQCKNCGQKNRVPAVGSSAPRCGRCHRPLPWLAEAGDDDFAEVAEGSPVPVIVDFWAAWCGPCRMVSPALDRVAEDLAGTVKLVKVDVDRSPKLSERFTVRNIPYLMVMRGGRVVAERAGAAPAAELRTWVDGAIATAGREGG
>NC_013595.1|WP_012890678.1|4483265_4484882_+|FAD-dependent-oxidoreductase
MDAFAETPDHHGAFPRLSDEQIARLAPHGVRRPTRPGDILFREGEDCPDFFVILAGKAAVIQDERVVRVHGPGRFLGELGLLTGQKAFTTSVVCEAGEVLAVPTWRLRQIVAHDPELGDLILRAFLIRRSLLIGSGAGLRIIGSRYSPDTRRLREFAARNRLPHRWIDLEEDEEAEALVRNLGMAPDETPVVILGGTRVLRNPGNAELAREIGLPVPSAPEDVFDLVIVGAGPAGLAAAVYGASEGLRTVVLDAVATGGQAGTSSCIENYLGFPAGISGGELAERAVIQAKKFGAHLGVPAEATSLKRRDGHYTVGLRDEPPVEGRTVVIATGARYRKLGVPRLEDFEGNGVYYAATLAEVAFCRGEPVVVVGGGNSAGQATIFLARHADSVRLLVRADDLAQDMSRYLIDRIESHPKVEVMLRTEVRELVGAHALEAVVAEDTRTGERLRIDTRAMFVFIGADPCTTWLAPEIALDDRGFVLTGFDDGLPLETSMPGVFAVGDVRSQSVKRVASAVGEGSMAIRLVHEHFTRRQASQ
>NC_013595.1|WP_043652383.1|4484875_4487125_-|AAA-family-ATPase
MILRLLGTTADTTGSMVLVEGEPGMGKSLLLAEAATVAAARGTAVATGRADELGRLTPLGPLLSALAEWPPPVALARGDSPDGPGLLLWLAEQVRTTLERRTESEPLLVTLDDLHWADPATLMALRTLPSRLASHPLAWLLARRTTSEHDDSGRLFDLLEEEGATRIRMLPLDDGAVAEVIADTLDAAPGEELAALSAQAGGNPFLLLELLTGLREEDAVRVSSGVARLTGTALPQRVHTAVRRRLGEVSTKTRHLLEAAAVLGRSFSPAYAAEMLGETPAALLPALEEAIAAGVLAATSDELTFRYELVWRSIVETVPAPVRQALHRQIERNPPARQPPRHQRADGSSAETLVLLSLLAWDEGRLSRGLDLAREAAEMPGSGRHPQPRAVLTTMLTDLWLLDEAETALAGAAEEAVGQPEWTAEIPVLRARLDLTAGRLGSAIEHAEAGLTAADTLGVPALAASALSVLGAASLRAGDLPRAIRYLKNDLARGPQGAPPYVRLRSELAAGRIDEARGGAASGMSSLSRVYDALPRHTGALTSEPTAAAWLVRVAMAVRDERRADAVVDAAEGIAWRNPCLLNPSVAAAHARGVRDRDPEALVRAMTEHTDPWARASAAEDLGVLLSADFDARDLAVDSLNSALVCYGSVEAARDAARVRGRLRGLGERRRHWVRTDHPVSGWASLTGTERAVCDLVAQGLTNRQAAEQMFISEHTVAFHLRQVFRKLGIHSRVELARLAAQQSVRPDH
>NC_013595.1|WP_012890680.1|4487326_4488067_-|GntR-family-transcriptional-regulator
MTAKLSIDLDRSSPVPLYFQVAEQISEAIQRGDLPPGSRLDNEILLADRLGLSRPTIRQAIQYLVDKGLLVRKRGVGTQVVHGQVKRSVELTSLYDDLRRAGQEPATRVLALESGPADERIAAVLGVATGAEVLHLERIRYAAGEPLALLHNWLPVGLAPLTAESLQERGLYELLRSAGVRMRVANQRMGARAATATEARLLGERRGAPLLTMLRTTYDDQGRAVEHGSHVYRASHYSLEVTLIER
>NC_013595.1|WP_012890681.1|4488296_4489619_+|lantibiotic-modifying-protein
MSPEPGAESPLRTAVMAARWIRSAAVDDGQGRHWRANPDVRGRSALPGQPLSLYSGAAGIVLFFLELAAATGDESYFDDAVAGARYLAATWREQADLSLHHGLAGVMFALAEAGWATGESSFEVEAGAVADHIVRSARPVDGGLGWTGDPAQRGDGGIILGLLHAAGILGVPAYQEIAVEAGARIAELAVPGHRFGDGACADLPLDAVTPGFLSGTAGTAFLLARLYGLTGQTGFLKAARRGADFVRAISVVTERCAMVPHHIPQGRDLHYLGFCSGSAGVARMFYELYRVAGDAGDLDWVERLARGIVRSGTPGRQTDGHWNVACQCCGTAGLVELFVGLWAATGRQTHLEFAHELGVNLIGRATRHGEQGSRWYQAYRRLRPWEVTADTGYMIGAAGIGAALLHLDATTRPQEVRRLMLPPDNPFPAIPLPTATLRRT

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Crispr_ID: NC_013595_30

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_30

5791860-5791941

Orphan

Consensus_repeat	Method
GAGTGTCACCCTGGAGGGCGGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_30

>merge|NC_013595|30|5791860-5791941|CRISPRCasFinder
GAGTGTCACCCTGGAGGGCGGCGGATTCTGTCGTCGGGGTTTCTCGGCCGCCGTCACAGGGTGTCACCCTGGAGGGCGGCGG

>NC_013595|30|28|5791860-5791941|CRISPRCasFinder
GAGTGTCACCCTGGAGGGCGGCGG	ATTCTGTCGTCGGGGTTTCTCGGCCGCCGTCACA
GGGTGTCACCCTGGAGGGCGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_169369563.1\|5798016_5798832_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_013595.1\|WP_012891778.1\|5789756_5790866_+\|o-succinylbenzoate-synthase	unknown	unknown	gnl\|CDD\|239433
NC_013595.1\|WP_012891789.1\|5799534_5799897_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012891785.1\|5796627_5797536_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|236676
NC_013595.1\|WP_012891777.1\|5788965_5789760_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225910
NC_013595.1\|WP_012891776.1\|5787354_5788923_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NC_013595.1\|WP_052317206.1\|5793406_5794012_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013595.1\|WP_081453455.1\|5800565_5800823_+\|FBP-domain-containing-protein	unknown	unknown	gnl\|CDD\|379860
NC_013595.1\|WP_012891770.1\|5779225_5780707_+\|hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_013595.1\|WP_012891779.1\|5790983_5791829_-\|M55-family-metallopeptidase	unknown	unknown	gnl\|CDD\|176450
NC_013595.1\|WP_012891773.1\|5783311_5784106_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_013595.1\|WP_148269201.1\|5784042_5785767_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224048
NC_013595.1\|WP_012891788.1\|5798988_5799531_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|235811
NC_013595.1\|WP_012891772.1\|5782370_5783315_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_013595.1\|WP_148269666.1\|5794117_5795413_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214748
NC_013595.1\|WP_012891786.1\|5797582_5798020_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224427
NC_013595.1\|WP_012891784.1\|5795567_5796515_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238042
NC_013595.1\|WP_012891790.1\|5799954_5800524_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NC_013595.1\|WP_012891771.1\|5780821_5782369_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173853
NC_013595.1\|WP_012891775.1\|5785822_5787358_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238622

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_169369563.1\|5798016_5798832_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.51029e-29
NC_013595.1\|WP_012891778.1\|5789756_5790866_+\|o-succinylbenzoate-synthase	gnl\|CDD\|239433	cd03317, NAAAR, N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building blocks for antibiotics, herbicides, and drugs. NAAAR is a member of the enolase superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	3.31006e-172
NC_013595.1\|WP_012891785.1\|5796627_5797536_+\|aldo/keto-reductase	gnl\|CDD\|236676	PRK10376, PRK10376, putative oxidoreductase; Provisional.	1.23842e-96
NC_013595.1\|WP_012891777.1\|5788965_5789760_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225910	COG3375, COG3375, Uncharacterized conserved protein [Function unknown].	4.49022e-48
NC_013595.1\|WP_012891776.1\|5787354_5788923_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	3.87163e-13
NC_013595.1\|WP_052317206.1\|5793406_5794012_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.20259e-08
NC_013595.1\|WP_081453455.1\|5800565_5800823_+\|FBP-domain-containing-protein	gnl\|CDD\|379860	pfam16571, FBP_C, FBP C-terminal treble-clef zinc-finger. FBP_C is a family from the C terminal end of fibronectin-binding proteins. It forms an extended four-cysteine zinc-finger with a unique structural fold. Fibronectin-binding proteins bind to elongation factor G - EF-G, which is mediated by the zinc-finger binding to the C-terminus of EF-G. FBPs release ribosomes by competing with them for EF-G.	4.45651e-12
NC_013595.1\|WP_012891770.1\|5779225_5780707_+\|hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	8.08064e-55
NC_013595.1\|WP_012891779.1\|5790983_5791829_-\|M55-family-metallopeptidase	gnl\|CDD\|176450	cd08663, DAP_dppA_1, Peptidase M55, D-aminopeptidase dipeptide-binding protein family. M55 Peptidase, D-Aminopeptidase dipeptide-binding protein (dppA; DAP dppA; EC 3.4.11.-) domain: Peptide transport systems are found in many bacterial species and generally function to accumulate intact peptides in the cell, where they are hydrolyzed. The dipeptide-binding protein (dppA) of Bacillus subtilis belongs to the dipeptide ABC transport (dpp) operon expressed early during sporulation. It is a binuclear zinc-dependent, D-specific aminopeptidase. The biologically active enzyme is a homodecamer with active sites buried in its channel. These self-compartmentalizing proteases are characterized by a SXDXEG motif. D-Ala-D-Ala and D-Ala-Gly-Gly are the preferred substrates. Bacillus subtilis dppA is thought to function as an adaptation to nutrient deficiency; hydrolysis of its substrate releases D-Ala which can be used subsequently as metabolic fuel. This family also contains a number of uncharacterized putative peptidases.	2.02501e-124
NC_013595.1\|WP_012891773.1\|5783311_5784106_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.01149e-69
NC_013595.1\|WP_148269201.1\|5784042_5785767_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	0
NC_013595.1\|WP_012891788.1\|5798988_5799531_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|235811	PRK06474, PRK06474, hypothetical protein; Provisional.	5.70271e-42
NC_013595.1\|WP_012891772.1\|5782370_5783315_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.84647e-110
NC_013595.1\|WP_148269666.1\|5794117_5795413_+\|hypothetical-protein	gnl\|CDD\|214748	smart00631, Zn_pept, Zn_pept domain.	8.18411e-21
NC_013595.1\|WP_012891786.1\|5797582_5798020_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|224427	COG1510, COG1510, Predicted transcriptional regulators [Transcription].	1.73131e-16
NC_013595.1\|WP_012891784.1\|5795567_5796515_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	3.78132e-09
NC_013595.1\|WP_012891790.1\|5799954_5800524_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	1.85567e-18
NC_013595.1\|WP_012891771.1\|5780821_5782369_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	1.69694e-109
NC_013595.1\|WP_012891775.1\|5785822_5787358_+\|amidohydrolase-family-protein	gnl\|CDD\|238622	cd01297, D-aminoacylase, D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics.	5.67855e-79

>NC_013595.1|WP_012891779.1|5790983_5791829_-|M55-family-metallopeptidase
MRVYISIDMEGVTGIATMDQVVRGGHGYPRSQRLMTAEANAAIEGAFSAGADSVLVNDSHGTMDNLLHEELDPRARLIFGTPKLDCMAEGISAEHDVAMFLGYHAAAGSPGVLAHTYSSHFYEVRLNGRPVSEAEVNALQAAAVGVPVGLLTGDDVICGVAEKAFPGVRTVAVKIAHGHTAADSLSPSEARRLIREAAAETVRGAGEMAPLQLPEVLELEIDMPSTPAAELGAQIPGVRRIADKTLAATFGTPSEVLGCVTVCYHLAADAMISRMALYGRR
>NC_013595.1|WP_012891778.1|5789756_5790866_+|o-succinylbenzoate-synthase
MKLDAVELREVALPLVSPFRTSLGTQTVRTALLVRVLSDEGEGWGECAAEDEPTYCPEYLAGAADVIKRFMLPALAPLDLEPAAVGPALRHLRGHPMARAAVETAVLDCWLRARRTSLAAHLGGVRRRVRVGVSVGITETVDALLDTVDRHLTAGYARIKLKIEPGWDLEPVRAVRETFGAGVMLTVDANTAYQPGDLRHLAKLDAYGLALVEQPFAPDDLHAHAALAARMDTPVCLDESITSARDAAEAISRGACSIINIKPGRVGGYLEARRIHDLAQANGVPVWCGGMLETGLGRAANLALASLPGFTLPGDISATERYYHRDITRPFVLDGGELPVPVEPGLGVLPEEADLQACTTAVETVSCTF
>NC_013595.1|WP_012891777.1|5788965_5789760_+|GNAT-family-N-acetyltransferase
MLRPMAELLISAPAGVKIRSLRGAGALQRADRLLREVWGTRRGDDPPIPLDLMCAFAHTGGYVGGAFLDGELVGVAAGFRTADDSLHSHVAGVAAKARGRGVGRALKEHQRAWAAGNGLVAVSWTFDPLVRRNAFFNLTRLGARAGAYLPDFYGPMSDGINDGGPSDRLFVTWPIEEAAPPPVSERDGVVVVDETGAVWDAEGAPLLRCATPVDVESLRATDPAAAGRWRAALESGLGGALDRGYRVTGFTRSGWYLLARGGAA
>NC_013595.1|WP_012891776.1|5787354_5788923_+|helix-turn-helix-domain-containing-protein
MTARGRVTLGVLIDSLGPDLVRPLALPHGREPLVGAPVIYDPEEPQAGLDGAVLLVTGRPSAEILARAGESNVAVVVARPGTCDEQALVTAAEAAGTALLAAPPELSWGQLYTLVDALLAVVAPAEDPGGDRATDLFVLANEVAARVGGAVAIEDLAMRVLAYSTVEGQRIDELRKEGILGRRVPAHPTNPEEYAAVLRADGVAWSYEPREFYPRLAIAVRAHGEVLGTIWVVQAEDPLAHDAAAVLEEAAAAAAPHLARINLAADEARRRRDECLGWLLRGIGAVDELATSFGLLPGEPVTVVTLGPYAGPADAFAATHAADLLRTAFVAYRIRAATGVVNGRAYAIVAAEAAAPLLRRITVDTLGRVSERLGGGWRAGVGRTAVSVAAVPASARQAEEALRAVCGPFTRELAASHEELSAALFLMDVEAALRPKPSLYGEPLALVASHDARHGTQYVHSLAVWIGAHHDVPRAAELLSLHPNTLRYRLRRIGELIALDDPDTRLVLALQLRLNGATKRTG
>NC_013595.1|WP_012891775.1|5785822_5787358_+|amidohydrolase-family-protein
MYDLLLRDGTVHDGLGGAPLHADVAIAGGRVAAVGHDLGPARRVIGVSGLIVGPGFVDPHSHSDTVPFLEEPQPFKLLQGVTTEIAGNCGFSCGPVDPETTSFIPAELAGAAFPTLGEYLDAAEAAGPSNNMAVLAGHNTLRLAAAGMNAEITSDGLARMCELAARSFEAGAVGLSSGLEYVPGAYADLEELVALALVAKRWDLPYATHMRSESEGLADALDEAIAVARRAGVRLQVSHCKASGRAVHGASAMVLDKLAQARRSGVDVRADVYPYLAFGTMLVAVLPPAACEGGERALLARLADPAERAALRALAESPDTGTGVGFWRELHPSDVQILVHNDPGIEGRRLADLGGDPWEALCELLRLDPQASGVFHTMHERDLAAFLADPLISIGSDNGPPVGPTHPRTFGTFPTYLGTYVDKEDMPEAIRKLSSAVAAQFGLAGRGWLGPGAIADLCVFDPGTIGHAGTYQRPDVRPTGVEHVFLSGRQVVADGEFTGGRHGRMLRRGGR
>NC_013595.1|WP_148269201.1|5784042_5785767_+|ATP-binding-cassette-domain-containing-protein
MRGHPAGRPRVRVAVEGRPAVRISELRISGSGLIVDGVDLEVSGGETVGLVGESGSGKSLTARAAAGLLPKGLRATGSVMLDGRELLGARERVWRSVRGTRVSLLMQDPFAMLNPLRTAGAHVAESLRGRQDRAEVLRRLAEVGIDDPAVAGRHPFQLSGGMRQRVALAAALAADPELLIADEPTTALDATTQHEILMLIKGVQRARGMGVLLITHDLRVAFELCDRVAVMYAGRVVEQGPPAEMGKAPAHPYTAGLLAAVPTAGRRLHRLVGIRGSVPAAAEVSATCAFAARCDQATPECAHARPPLRELRPDRLTACLHEVRPRISVEEGPRDRRRVTDDAVLRVTGLRKTYGAHVALGGVSLHVNRGETVGVVGGSGSGKTTLARCVLGLVRPDAGTIELADPVRPRHRLVQCVFQDPSTSLNPALTVGATLAEAAAQGPEEGRLTVAELLELVGLPASYAGRRPAGLSGGERQRVAIARALSVRPALLICDEPVASLDVSVQAHVLELLREVGTSMVFVTHDLAVVRQMADRLVVLSRGEVVESGGTAEVLDAPAHGYTRSLLASVPATP
>NC_013595.1|WP_012891773.1|5783311_5784106_+|ABC-transporter-permease
MRAILVAVLGLAAVAAVAGPWLAPYDPAAQDLALSAAGPSVAHWLGTDDLGRDVLSRLLAGAGSALMWPVLVAVCTTVLSTTLGLLAGYRLGWVDALMMRTVDLAIAMPGMLVLIVVVGVLGGGYGWAVLAMAVLFTPGDIRVIRGLTLAQRELAYAEAARTLGLPPSRIMFRHLLPNLAPTVVAGALLSFVAALVALAGLSFLGIGLPAGTPDWGLMVEENRGLLDLNPWASIAPAALITVVACAATLLGDRAFESLSKGGLR
>NC_013595.1|WP_012891772.1|5782370_5783315_+|ABC-transporter-permease
MAVLKRLCAAVLLLGVLSVLTYGLLAAAPGGPEQVLLGGRPSTPETRAAIREQYHLDDPFPVRYARWLGDALQGDFGTSIYSREPVTTVIADRLPVTAGLAGYALVLTAVVGVPAGLAAAMRRGGRLDQGITLTSLIALSIPPFALSILLLYGFAVALSWFPVFGAGDTPMERLVHLTLPAIALAAAQAAIVVRQMRAAALDLAAQDFLTFARARGLSRRRVWVSYALRNAALPVLTVGGLLLAANLTGSVFVEQAFGLHGLGALLVGAVGQKDIPVVQALVLLSGAIVIAVNLLVDLAYVAVDPRVRHREAAA
>NC_013595.1|WP_012891771.1|5780821_5782369_+|ABC-transporter-substrate-binding-protein
MTYAKAATAAVVLALTTACSSGGAAPQARDSLVWATVNPPNSLDIAHGFNNASTLIQSAVLDTMLALDTHGAPAPRLATQWTQPDPATYLFTLRKGVRFADGTPLTADDAAFSLRRHLDPKVASQAASYFTTVEKVEAVGEGQVEVTLKRPNPAFLAMAAIAWQVTPRKLAEAHPQDLGSPEVGTMGTGPFKVTKFSLTSGVVLERNASYWGRKPALRMVEFRTITDPETLRLAVRSGEVDATDGLSARDARKWIGLPGVKTIFYPGNNIGYLSLAVTSGPLKDVHVRRAIAHAVNRGAVSDLMTSGHGGPAATMLPSPQLTALYGDDAPTLPAYPYDVEAARAELARSAYPQGFELAVPYSSTGDSGTVMQTVAADLAKIGIRLTLQPSPADQYRSRMMEHDRLSIHYVNLAYGTPDPLEVLPDMVSRAAAEPQGFNFAGYGTAATDKQLDALASATGQDRKARVTALLTEIAEEVPYIPLFATDNAVALNERFTGTFTTWSLDHFTTIRLAGR
>NC_013595.1|WP_012891770.1|5779225_5780707_+|hydrolase
MDLERVKREVFSLVGPDTPGLAVGVYTGGAAVLTAAQGAACVEFGVPVDERTRFDIASASKQFTAACVLLLERDGKLGLDDDVRAHVPELSLEVPVTLRQCLQHTGGLPEWYGLQALTGVPLAEMTERRLLEVLTGIRHTSFAPGTGWAYSNTGYVLAAVVVGRVAGSSLAEFARERLFEPLGMAESVFRDDASVPLERLAYGYANAQGEPRRADTQESAVGDGGLVTSVAELAPWFGFLADGRVLGADLRDRLLERAVLADGTVRPYALGIYHGEDWFGHAGGMHGYRSNLLYLPDPGVGIAVLSNQTAIDPVRLSHRLARLLLGGEEPPRPEPGTSAPPERLHWHDPAGDGTLTLEPTAEGIAIPDVGVFTTGADGRWHGTGDAEGAWLEIGGDRLLLRTGPPSRPPVVFHAAEPPSDAPMADGVFRSPELGIDATVSDGEVRVGRELRLPSAPAPGGAWQAGPFTLRLHEGDLLVSGAGLRRMRFEGTHG
>NC_013595.1|WP_052317206.1|5793406_5794012_-|TetR/AcrR-family-transcriptional-regulator
MTRAESKAANKRALIDAAREVVGKQGSQAKLEDIAELAGLTTGAIYSLFGGKNDLMVAMVDDYAGPLDLRPIEAAGPGLPLEEVVAEVARRFHRMSADPGAAGKLLFETRVLDLVLNDPELLGKLTVSVRSTEVDLAELFTGREYDGTPVTGGQAVRLARALKALLSGLGQSVVLGVHDGSEEFFVDVAHALITPKVLGPA
>NC_013595.1|WP_148269666.1|5794117_5795413_+|hypothetical-protein
MSRVPDYTAFPTVDQMHAELDELAAAHPGLVRLRRIGTSRLGEPLRVATIGSGPHDAVIIGGPHPNEPIGSLTVSSLLRRLVEDASLREDFGYRWHLIPCVDPDGARLNEGWYVRPGDRRAYAEHFYRPAEADQVEWTFPLTGEDYFFDRTLPETEALMRLMDEVKPAFVYSLHNGELQGAFYYLNRDEPALAARLAAIATAQGLPLHMGPPEVPSAVPIGPAAYRTPSGAELGAIYGTGGGSVDYANRFDALHLVTELPYWADPRVADETPTDQGYGEAIQAGLAAQRALIAELTQSMSAVRADLTVRSPFRLALQDFLDTHDEFISEWESFPGTDRRATVAEVVGNRQLVHIMRLRYSGTCLRMLDAELGAGNRTPAIRAERARLGARFDDWFTEAEADATATPIPIRTLVAVQLGAALLAAESAKRKP
>NC_013595.1|WP_012891784.1|5795567_5796515_-|winged-helix-turn-helix-transcriptional-regulator
MRFAVSPMWEVGTSFRLLTSGSAHPVHRPWLEQVRPRVAAAGLDRGWLAELIPPSGYVPDFLNPAPAGPAPALAEELARIRAAPAGRVRQDLDHLEHHQGRAGPRSRTLYAEPQARLARVAEEIETYWELALAPYWARVRAVLDADVFHRARQVAEYGAGHLFNDLHTSVSWDDNTLRLVRRQRTLSRTTAGAGLLLIPSAFTGPSLLTRVTPPDPPQLAYPARGIGSLWESRPATSTGALAAVLGRSRTLLLTELDAPASTTELARRTGLSPAGVSQYLTALRDAGLVSAHRAGRSVLYARTAAAESLLTAANP
>NC_013595.1|WP_012891785.1|5796627_5797536_+|aldo/keto-reductase
MTSETITATAAGTWKLGDLEINRIGFGAMRLTQDGPAFAAGAVPSDRGRAVSVLRRAVELGVNHIDTAAFYFSPLRSANQLINQALAPYPDDLVITTKVGPGRGPSGEWLPHATPEQLRGQVEENLRQLGRDHLDVVNLRIIGTDSIAERFGALARLRDAGLIRHLGISNVRPEHLVEAQAIAPVVCVQNRYGIGAQPEQDAFLRTCGEQGVAFVPFYAIAGAGGEAGAHGSDSDEVLAVARAHGVSAAQVRLAWTLSRGPHVLAIPGTGNPDHLAANVAAGALRLSEDDLAVLDSLHRGGA
>NC_013595.1|WP_012891786.1|5797582_5798020_-|MarR-family-transcriptional-regulator
MSAARRRAFVTSVGDLLASWNLPHATGRVYGLLLVTEEPASLDAIAAELELSKGAVSTAVRQLDSWGLVKVIPQPGSRRLLVEATGGIESLLEASHSRARALIAALRDGETLVDPGPAQDRLRDVIGLFAGYVDVGSQILNRHRR
>NC_013595.1|WP_169369563.1|5798016_5798832_-|alpha/beta-fold-hydrolase
MNLPSVLSLQGCALRYDDSGGDGVPLVFSHGAGADHVMFDAQSAYLRARGYRVVTWDMRGHGLSRPAGVRFTAEQAIADLCGLITHLALDRPVLVGQSLGGNLSQAVVRRRPDLARALIVIDSTWNTAPLSWKERLLVKAAAPSLSMIPAKSLPGMMAEASAVTEGARADARRAFSQLSKKEFVQVWRATVEFLDPDPRYRTPVPVCLIRGERDRTGNISTAMPRWAEAEGVKEVVIPGAGHISNQDDPHAVNAAIEAFLRTVPASKRAPR
>NC_013595.1|WP_012891788.1|5798988_5799531_+|helix-turn-helix-domain-containing-protein
MTVPKERWAELALHPVRIRILGATAGGRRTPSELARLLPDVPQATLYRQIATLAKGGMLNVVEERRVGGATERVYALPEGGMTPTAETLASTSPEEHARYFTAFVSSLLSEFSRYLAREHIDLVADGVGYQQMVLHLDDEEFIRFAQGFAELVRPLLANEPGDDRVPRLLATVLLPLTKG
>NC_013595.1|WP_012891789.1|5799534_5799897_+|hypothetical-protein
MATVMITSGSITIEFGTWERIFTGRARHTIPLRAVRQAVTTDQPLRIPHGARKGLTVSGHTKIGVWGIYGGPRQLVSANRNLPGVHLLLDRASSGGEFDEVVLSIPDADRFVEALRAEAA
>NC_013595.1|WP_012891790.1|5799954_5800524_-|TetR/AcrR-family-transcriptional-regulator
MARAGLTAERLTRAAADLADEIGFQNVTVSALARGFGVKPAALYSHVRDARELRVRVALLALAELADGAASALAGRAGKDALVAFANAYRDYAKEHPGRYAAMQVELDSERMDTGAAGRHAEMTRAILRGYELPEPDRTDAVRMLHSTFHGYVSLETAGGFRRHPREVDASWSRTLDALDAVLRNWPPA
>NC_013595.1|WP_081453455.1|5800565_5800823_+|FBP-domain-containing-protein
MLSARKPASPPARPVTERAIRTSFVNRSRGEAERLDPPEALTDHPREDLDVLGWRDPGALYSPIYHISHITSQIGQCRRWAININ

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Crispr_ID: NC_013595_31

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_31

5912872-5912985

Orphan

Consensus_repeat	Method
CCCGCCGCCCGCCGGAACGGCGCGTGCTCCG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NC_013595_31

>merge|NC_013595|31|5912872-5912985|CRISPRCasFinder
CCCGCCGCCCGCCGGAACGGCGCGTGCTCCGGGGTGCGTGGGAGCAGGTCCGGGCACCGCTCCCGAAAGCTCTGCTCCCCTGCCCCGCCGTCCGCCGGAACGGCGCGTGCTCCG

>NC_013595|31|29|5912872-5912985|CRISPRCasFinder
CCCGCCGCCCGCCGGAACGGCGCGTGCTCCG	GGGTGCGTGGGAGCAGGTCCGGGCACCGCTCCCGAAAGCTCTGCTCCCCTGC
CCCGCCGTCCGCCGGAACGGCGCGTGCTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_043652964.1\|5909333_5909672_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_013595.1\|WP_012891895.1\|5914005_5914569_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NC_013595.1\|WP_081453456.1\|5919326_5920472_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226951
NC_013595.1\|WP_012891902.1\|5920704_5921283_-\|DinB-family-protein	unknown	unknown	gnl\|CDD\|378981
NC_013595.1\|WP_043656711.1\|5914707_5915118_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319901
NC_013595.1\|WP_012891889.1\|5908150_5909074_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_013595.1\|WP_012891894.1\|5913127_5913964_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187578
NC_013595.1\|WP_043652967.1\|5916336_5917095_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_013595.1\|WP_012891885.1\|5903653_5905288_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_013595.1\|WP_012891888.1\|5906564_5908154_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226089
NC_013595.1\|WP_012891893.1\|5911647_5912838_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NC_013595.1\|WP_012891887.1\|5906117_5906636_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224427
NC_013595.1\|WP_043656709.1\|5905555_5906008_+\|type-II-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|235443
NC_013595.1\|WP_012891891.1\|5909668_5910610_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012891903.1\|5921345_5922344_+\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_013595.1\|WP_012891897.1\|5915295_5916279_-\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_013595.1\|WP_148269206.1\|5911047_5911305_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043652970.1\|5918361_5919126_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NC_013595.1\|WP_012891899.1\|5917110_5918298_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NC_013595.1\|WP_012891892.1\|5910790_5911093_+\|mitomycin-resistance-protein	unknown	unknown	gnl\|CDD\|371697

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012891895.1\|5914005_5914569_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.03734e-34
NC_013595.1\|WP_081453456.1\|5919326_5920472_+\|hypothetical-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.7999e-27
NC_013595.1\|WP_012891902.1\|5920704_5921283_-\|DinB-family-protein	gnl\|CDD\|378981	pfam12867, DinB_2, DinB superfamily. The DinB family are an uncharacterized family of potential enzymes. The structure of these proteins is composed of a four helix bundle.	9.95431e-11
NC_013595.1\|WP_043656711.1\|5914707_5915118_+\|VOC-family-protein	gnl\|CDD\|319901	cd07235, MRD, Mitomycin C resistance protein (MRD). Mitomycin C (MC) is a naturally occurring antibiotic, and antitumor agent used in the treatment of cancer. Its antitumor activity is exerted primarily through monofunctional and bifunctional alkylation of DNA. MRD binds to MC and functions as a component of the MC exporting system. MC is bound to MRD by a stacking interaction between a His and a Trp. MRD adopts a structural fold similar to bleomycin resistance protein, glyoxalase I, and extradiol dioxygenases; and it has binding sites at an identical location to binding sites in these evolutionarily related enzymes.	8.49938e-60
NC_013595.1\|WP_012891889.1\|5908150_5909074_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.17338e-84
NC_013595.1\|WP_012891894.1\|5913127_5913964_+\|NAD(P)H-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.68023e-59
NC_013595.1\|WP_043652967.1\|5916336_5917095_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	5.68843e-79
NC_013595.1\|WP_012891885.1\|5903653_5905288_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	5.92438e-131
NC_013595.1\|WP_012891888.1\|5906564_5908154_-\|hypothetical-protein	gnl\|CDD\|226089	COG3559, TnrB3, Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane].	6.51939e-96
NC_013595.1\|WP_012891893.1\|5911647_5912838_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	7.37089e-70
NC_013595.1\|WP_012891887.1\|5906117_5906636_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224427	COG1510, COG1510, Predicted transcriptional regulators [Transcription].	2.78823e-10
NC_013595.1\|WP_043656709.1\|5905555_5906008_+\|type-II-3-dehydroquinate-dehydratase	gnl\|CDD\|235443	PRK05395, PRK05395, type II 3-dehydroquinate dehydratase.	7.2924e-87
NC_013595.1\|WP_012891892.1\|5910790_5911093_+\|mitomycin-resistance-protein	gnl\|CDD\|371697	pfam11731, Cdd1, Pathogenicity locus. Cdd1 is expressed as part of the pathogenicity locus operon in several different orders of bacteria. Many members of the family are annotated as being putative mitomycin resistance proteins but this could not be confirmed.	4.06694e-28
NC_013595.1\|WP_012891897.1\|5915295_5916279_-\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.79076e-47
NC_013595.1\|WP_043652964.1\|5909333_5909672_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	4.57288e-13
NC_013595.1\|WP_043652970.1\|5918361_5919126_-\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	2.8402e-43
NC_013595.1\|WP_012891899.1\|5917110_5918298_+\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.84397e-85
NC_013595.1\|WP_012891903.1\|5921345_5922344_+\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.33007e-50

>NC_013595.1|WP_012891893.1|5911647_5912838_+|MFS-transporter
MPLAIYMLGLAVFAQGTSEFMLSGLIPDIARDMHVSIPASGSLTSAFAAGMIIGAPLMAILSLRWPRRRALLIFLVVFLLAHVLGAVTTSFGVLLATRVVGALANAGFLAVGLAAATAMVGPDAKGRATSVLLGGVTIACVAGVPAGAVLGQLWGWRSAFWAVAIVSVPAVIAILRSVPATGPGSGSAETSARGELRSLRDPRLLVTLLLGALVNGATFCTFTYLAPLVTDVTGFGSGWVPAMLALFGLGSFVGVTAGGRMADTRPMPLLVAGGAALLAGWIVFAVTAGNPVATLVLVFVQGALSFAVGSTLISQALYAATGAPTLAGGFATAAFNVGAAAGPSFGGIAIGAGLGYRSPLWVSALLVALALATAGVALGVRRGTANRREEAPAPAR
>NC_013595.1|WP_148269206.1|5911047_5911305_-|hypothetical-protein
MFGASPSSGAPEPGRGLDATALALMAGVSCRLVRTAVVDPLALAAPVLSWKTRLSTAWPADLTPARGAGGRQRTRSESRRLRSAV
>NC_013595.1|WP_012891892.1|5910790_5911093_+|mitomycin-resistance-protein
MSSPHRRDGTAGQTDLLELVNVGPAVVRHLARVGITRTGQLAGLDPVEMYDRLCALDGRRYDPCLLDTFMSAVEQAGGGPARPWWDYTAERKRLLSERVR
>NC_013595.1|WP_012891891.1|5909668_5910610_+|hypothetical-protein
MSTNTLTDRYVHEVVRRIPADQRDDVADELRTTIADTVDARDAADPDSAEREVLTEMGDPIRLAARYADRPLTLIGPELYPTYIRLLVTLLSAVLPVVTAALVVVDVLDNNDLGSAIGTGIGAALTVGAQMIAWLTVVFALVERSRNRKGASAASGTWTPDDLPELPRPDKRVGAAGAAAVGNALLIGLIVWQHIAEPYRADGNAERLQVLHPDLWSGWIWPILAGLAGLVALNLVRIAARGWTVRLAAWYALAEAAFALPLAWILYRRVFFSPEFLTDFSGKWTDSFYTVTALGVLVVSASAVVSRFREARR
>NC_013595.1|WP_043652964.1|5909333_5909672_+|PadR-family-transcriptional-regulator
MSTEELILSQAQELRRGTVVLACLALLDEPQYGYALLETLNDAGVTVDGNTLYPLLRRLEKQGLLTSEWNTDESRPRKFYRVSPEGFRVRAGLVREWQDLVSSISRLTKENR
>NC_013595.1|WP_012891889.1|5908150_5909074_-|ABC-transporter-ATP-binding-protein
MTDAIHVSGLVKTFGRTRALDGLDLDVRRGEVHGFLGPNGAGKSTTIRILLGLMRADAGRARLLGGDPWADATDLHRRLAYVPGDVTLWPNLSGGEVIDLLGRLRGGVDEQRKASMVDRFELDLRKKGRAYSKGNRQKVALVAALASDVELLILDEPTSGLDPLMEAVFRDSVAEEKARGRTVLLSSHILSEVEALCDRVSIIRGGRTVESGTLVELRHLTSTSVVAEVASPPYGLAELPGVSDLHIEGMRVSCQVEPRHLDELFQRLTALGLRGVTAAPPTLEDLFMRHYTPARSGGHEPRTEATS
>NC_013595.1|WP_012891888.1|5906564_5908154_-|hypothetical-protein
MSALTGTGVLARLVVRRDRLILPLWGLPAALYPSSIAGSTAGLYPTAEALRGVGDAAMANPSQAAMRGPVFEASVGGLTAHTVTSSGGMLLGLVSMLLMIRHSRGEEESGRRELAAAGVVGRHAPLTAALAVVLAANLVIAVLMAGALTGVGLPASGSFALALSLAAAGWTFAAVGALAAQLTESVAAARGIGIGVFAVFFLIRAVGDAGGVAWLSWASPLGWTLRVRPFAGERWWVFALLLALVVALAGTAYRLSSRRDLAAGVLPARLGPVAAAPGLRSAPALAWRLHRGQLVAWIAGFAAGGLALGGAVSGGIEGQIDAPQIMEMIARVGGGDAEPADFFVNYLLSMLAWIIAAYGILSALRLRTEETAGRADLVLVTPTSRIRWALSHLFMAVVAPAAAMVALGAATGLAYSARGGDPGKFPLVLGAALAYLPAVWVMTGIAVVLAGLLPRLSTAAWGIWVAFILLDVLGTLGQVDESVLNIIPFVHVPWIILGQTAVAPLLLMTVVAVALGATGLAGLRRRDIA
>NC_013595.1|WP_012891887.1|5906117_5906636_+|MarR-family-transcriptional-regulator
MTPDAQGFLERFAMIMSESGYPRMAARVFAALLVSDDGRLTAAELAERLQVGPPAISGAVKYLMHVGMVARERDPGERRDRYRVDQVAWFTAAMSSDEIFRRFEEGAREGLEVFDQDTPVGARLEEIRRFFAFLRREVPQLMDKWRELESRDVAAAQTGQPGGAQGDGDHGH
>NC_013595.1|WP_043656709.1|5905555_5906008_+|type-II-3-dehydroquinate-dehydratase
MTGVYVLNGPNLNLLGTRRPEVYGSTTLSTLEELCREEATRLGLDLVFHQSNHEGRLIDWIHEAGARVKAGESIGAVFNPGAYTHTSIALHDAIEGTELPVVEVHISNVHRREAFRHHSYISPIARGTIVGLGVDGYRLAIDALHRMSLR
>NC_013595.1|WP_012891885.1|5903653_5905288_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSDALIVVSNLSFSWPDDTPVFEDLSFTVPSGHTGLVAPNGAGKSTLLKLIAGALRPAAGSVTVAGVLGYLPQTLPLVGDLTVAEVLEIAPVIRALNAIEAGDASEEHFTTIGNDWDIEERTRAQLDRLGLGDVSLTRRLHTLSGGQVVSLGLAAQLLKRPDVLLLDEPTNNLDLDARHKLYGVLGDWNGCLLLVSHDRALLDRMDRIAELDRGELRSYGGNYTEYEEAVRAAREVAEKNVRNAEQEVRREKREMQQARERAARRAGNAARNLKSAGLPKIFAGTMKRRAQESAGRSNETHAMRVSEARARLDEAGRAVRDEQKISLELPGTGVPAGRTVFLGERMQVRYGERALFSGEGADLAIRGPERIALTGPNGAGKSTLLRVINGELEPEGGGTRRADGRVAYLSQRLDLLDLDRTVAENLAAFAPGMPEAQRMNLLARFLFRGSRIHLPVGVLSGGERLRATLACVLCAEPAPQLLLLDEPTNNLDLVSVAQLEGALQSYEGAFVVVSHDERFLAEIGVDRWLRLSEGRLLETGAPGA
>NC_013595.1|WP_012891894.1|5913127_5913964_+|NAD(P)H-binding-protein
MIVVSAASGALGRLVVDRLMTRVPAGEIVAAVRDPGAAADLAARGVQVRRGDYDDPASLRAAFGGARRLLLISSPELDPARRLSQHLAALDAAGAAGVGALAYTSFLGAASDGTGVTEAHHATEKAILGSGLPYTMLRHPYYSEAFLNPGLRAAVASGELTDATGGRGLNTASRADLAEAAANVLTGDGHLGRGYDFTGPLWTYPQLARTLAEVSGVPVAHREGPDDASGALRWLNGQVRAGALEAQTGDLQEVLGHPATTLRQAVTTALRPAAPGGA
>NC_013595.1|WP_012891895.1|5914005_5914569_-|GNAT-family-N-acetyltransferase
MQIFLETDRLTLRRFTGADEDNLVELDGDPEVMRFLNGGRPTPRDEIRDRVLPAFLGYYERFEGFGFWAAVERSTGRFLGWFHFRPRRDEPREGEVELGYRLRRAAWGRGYATEGSRALIHKGFTELGVDRVFAGTMAVNLGSRRVMEKSGLTLVRTFHQDWPDVIDGSEHGEVEYALTRADWQARR
>NC_013595.1|WP_043656711.1|5914707_5915118_+|VOC-family-protein
MAPSFNLIGLVVTDMGKSLAFYRRLGLDIPLSADSEPHVETALPGGLRIAWDTVDTIRSFDPEWAPSHGSARIGLAFACDDPQEVDRVYADLVQAGYEGHKQPWDAFWGQRYALVRDPDGNGVDLFAPLPQAPSAS
>NC_013595.1|WP_012891897.1|5915295_5916279_-|YafY-family-transcriptional-regulator
MRASRLLSLLLLLQTRGRMTATELSEELEVSVRTVYRDVEALSSAGVPVYADRGPAGGYRLLDGYRTRLNGLTAEEASSLFLAGLPGPAAELGLGEVAANAELKLLAALPPEPRFHASRMRERFHLDVPGWYRGADEAPFLGEVSEAVWDQRPLRMTYRRWGPRDVERLAHPYGLVLKGGSWYMVAAVGGGEPRTYRVSRIIAAEIAEGRFERPGDFELAAYWERYAADFRARMYTAEALVRVAPGIEAMFRYTVGADVADAALAEAGPPDDRGWVVVRLPIESVRHAHWLLLRLGADIEILEPAELRAQMAATVAELGGLYGAHRD
>NC_013595.1|WP_043652967.1|5916336_5917095_+|DeoR/GlpR-transcriptional-regulator
MESADRIRAIMSALRVSDTVSVAELAVEHAVSEMTIRRDLDELAQQGVVRRVRGGAVSLLLRGEEPPFGVREREAVEAKRRIAAEVASLLSDGEAVLLDGGTTNLEIARAIRDRRLTVLPLSLQAAHELGTAPRVRLVLPGGEVRPGELNLIGPLTENAIRSLRFDTAVIGCCGLSAEHGLTAHDLSDVAVKQAAISSARRVVVATDSGKFSRTAFGAVCPLDRLDMVVTDTALPPAEHDALIAAGVIVRTV
>NC_013595.1|WP_012891899.1|5917110_5918298_+|MFS-transporter
MHVTTADRGALLRGRVAVCLLFLLAGMAIGTWTARIPSIKQELGLSDGQLSLGLLGIAAGAIAGMQVVGRLVDRYGSVRVMLPMAFAQSVVLILPAYMPNLAALALALFAFGAVHGTLDVAMNANAVEVEQAMDRPLMSSFHAVFSIGGFIGAAVGGLLAHAAFTPAATFAVLAAAIAVLALWASRWAFAPPAAPARGADTDATGGAGTAGWDRGLLLLGLLGICCMIGEGAAADWSSVYLRDALGSSAGFAAAAYAAFSIMMTAGRLVGDRLTARLGPVTLVRGCGLLAASGLGAALLADHPVAAVIGFGCFGAGLSCIVPQVFSAAGRRDPARAGQALARVASLSYVGFLSGPVLIGSVAELVGLPRALVIPVVLAAFVALAATALRPPSLTK
>NC_013595.1|WP_043652970.1|5918361_5919126_-|TSUP-family-transporter
MDMAEIVLLLVAAAGAGWIDAVVGGGGLLQLPVLLMAGLSPVQALATNKFAAIFGTASAAVTYARTTKIDTGVAVPAGLGAVVFAGLGASAAAAISREALIPLVMVTLVGVALFVTFRPAFGTHPQPHLRTRARTVAAIAVAGAGIAFYDGILGPGTGTFLIIAFTTILGMDFVSGSAHSKIINSCTNLGALLVFAYQGHVLWLLGLAMAVCNIAGAQLGARMALRRGAGFVRVVLLCVVIAMVAKLGYEQFAA
>NC_013595.1|WP_081453456.1|5919326_5920472_+|hypothetical-protein
MPYMMVGTVLVGLLRLRETTVSTLVSIDPAVFASALPLIALTGLFLPVRALELTAARGLLGARIDSPPDRPARTWAERRRTAAWFTLHLGIGAVLAGATLALVPFAIWLSLLPLLGDRLGFLGSTVAAGWSGAWGPAAALVTLALLVYAAAGAGALLARLAPVLLGPAPADRLAALEERARRLATRNRLARELHDSVGHALSVVTVQAGAAGRVLDRDPEAARTALTAIEESARSALEDLDHVLGLLREEESGDRAPARTLTDLPELVRSTGAAAEITGDLSALPALVSREAYRIAQEALTNALRHGSGPARLAAAVHDDRLELEIRNQFRQRPGRAGRRGVAGMRERVTLLGGRLDAGAVDGEWRVAVRLPLRGGQEPVR
>NC_013595.1|WP_012891902.1|5920704_5921283_-|DinB-family-protein
MDADELDWNRTLREQWEFHWNHQLRARLDGLTDDEYFWSPVPDAWSVRPRGSSTAPVQLGAGDFTVDYAFPEPVPAAFTTIAWRLGHVIVGVLAARNAAHFGAPAASYETWEYAGGAATALDQLEAQLDVWTAGVRGLGEAALRVPIGEKEPFPEAPMADLVLHIHRELIHHLSEVCLLRDLYLHTKSGVPE
>NC_013595.1|WP_012891903.1|5921345_5922344_+|YafY-family-transcriptional-regulator
MAVAGGDERGTTERVLTLLGLLQQRQVWTGPELADRLGVTPRTVRRDVERLRTLGYPVHASQGVGGGYQLGPGQDLPPLLLDDEEAIATVVSLLAGAGGAVTGAGDAALRALTKLDRVLPTRLRHEVRALSGSVESFGGGRTPVDPEVLMTLARVCRDEVEAGFGYPSGSEVRRRRVEPYRLVASERRWYLLAYDLDRDDWRSFRVDRMTDVSARTWRFSPRAAPDAAPYVQEGVASRVYPHQARFLVHAPADTVRAQIPASAAVVRRRGSELCEVLSGAGSLDFVLMHVLMLGHDFEVLDPPELGRRCRALAERLLSAGAAIPPVPDVEES

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Crispr_ID: NC_013595_32

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_32

6157705-6157807

Orphan

Consensus_repeat	Method
AGCCGGTCAGGCCGGATGGGCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_32

>merge|NC_013595|32|6157705-6157807|CRISPRCasFinder
AGCCGGTCAGGCCGGATGGGCAGATCACGAGGGCTCCGGCCGGGGCCGGTGAGAGCGGTCAACCTCTGATCCCCTCAAGGAGCCGGTCAGGCCGGATGGGCAG

>NC_013595|32|30|6157705-6157807|CRISPRCasFinder
AGCCGGTCAGGCCGGATGGGCAG	ATCACGAGGGCTCCGGCCGGGGCCGGTGAGAGCGGTCAACCTCTGATCCCCTCAAGG
AGCCGGTCAGGCCGGATGGGCAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012892108.1\|6154730_6155411_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_013595.1\|WP_012892103.1\|6150068_6150635_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380569
NC_013595.1\|WP_043656796.1\|6152344_6153286_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NC_013595.1\|WP_012892121.1\|6167866_6169504_-\|ATP-dependent-DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|223588
NC_013595.1\|WP_012892116.1\|6163875_6164781_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NC_013595.1\|WP_148269681.1\|6156759_6157614_-\|FAD-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224238
NC_013595.1\|WP_012892102.1\|6149261_6150014_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|378278
NC_013595.1\|WP_012892118.1\|6165381_6165885_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NC_013595.1\|WP_012892119.1\|6166027_6166843_+\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|252734
NC_013595.1\|WP_012892112.1\|6160359_6160902_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013595.1\|WP_012892101.1\|6147844_6149026_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NC_013595.1\|WP_012892117.1\|6164906_6165143_-\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NC_013595.1\|WP_012892113.1\|6160956_6161643_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NC_013595.1\|WP_012892104.1\|6150783_6151554_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378937
NC_013595.1\|WP_148269680.1\|6146090_6147590_-\|carboxylesterase-family-protein	unknown	unknown	gnl\|CDD\|365897
NC_013595.1\|WP_012892120.1\|6166966_6167785_+\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|252734
NC_013595.1\|WP_063610295.1\|6161835_6162192_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_013595.1\|WP_012892115.1\|6162267_6163815_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187556
NC_013595.1\|WP_012892109.1\|6155486_6156740_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_013595.1\|WP_012892105.1\|6151550_6152348_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226663

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012892108.1\|6154730_6155411_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.08001e-67
NC_013595.1\|WP_012892103.1\|6150068_6150635_+\|hypothetical-protein	gnl\|CDD\|380569	cd06346, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.	1.5423e-06
NC_013595.1\|WP_043656796.1\|6152344_6153286_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	2.97231e-84
NC_013595.1\|WP_012892121.1\|6167866_6169504_-\|ATP-dependent-DNA-helicase-RecQ	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	1.99263e-134
NC_013595.1\|WP_012892116.1\|6163875_6164781_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.58041e-08
NC_013595.1\|WP_148269681.1\|6156759_6157614_-\|FAD-binding-domain-containing-protein	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	2.07847e-33
NC_013595.1\|WP_012892102.1\|6149261_6150014_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|378278	pfam09859, Oxygenase-NA, Oxygenase, catalyzing oxidative methylation of damaged DNA. This family of bacterial sequences is predicted to catalyze oxidative de-methylation of damaged bases in DNA.	1.52452e-117
NC_013595.1\|WP_012892118.1\|6165381_6165885_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	5.28917e-16
NC_013595.1\|WP_012892119.1\|6166027_6166843_+\|SAM-dependent-methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	3.86228e-92
NC_013595.1\|WP_012892112.1\|6160359_6160902_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.43626e-09
NC_013595.1\|WP_012892101.1\|6147844_6149026_-\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	2.82436e-98
NC_013595.1\|WP_012892117.1\|6164906_6165143_-\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	7.10907e-22
NC_013595.1\|WP_012892113.1\|6160956_6161643_-\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	2.15692e-41
NC_013595.1\|WP_012892104.1\|6150783_6151554_-\|ABC-transporter-permease	gnl\|CDD\|378937	pfam12730, ABC2_membrane_4, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	0.000675996
NC_013595.1\|WP_148269680.1\|6146090_6147590_-\|carboxylesterase-family-protein	gnl\|CDD\|365897	pfam00135, COesterase, Carboxylesterase family.	6.37768e-98
NC_013595.1\|WP_012892120.1\|6166966_6167785_+\|SAM-dependent-methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	1.82665e-92
NC_013595.1\|WP_063610295.1\|6161835_6162192_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.2039e-36
NC_013595.1\|WP_012892115.1\|6162267_6163815_-\|SDR-family-oxidoreductase	gnl\|CDD\|187556	cd05245, SDR_a2, atypical (a) SDRs, subgroup 2. This subgroup contains atypical SDRs, one member is identified as Escherichia coli protein ybjT, function unknown. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that generally matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.86339e-133
NC_013595.1\|WP_012892109.1\|6155486_6156740_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.17935e-42
NC_013595.1\|WP_012892105.1\|6151550_6152348_-\|ABC-transporter-permease	gnl\|CDD\|226663	COG4200, COG4200, Uncharacterized protein conserved in bacteria [Function unknown].	0.00252195

>NC_013595.1|WP_148269681.1|6156759_6157614_-|FAD-binding-domain-containing-protein
MARRPAGPYVDLRGLPGLSGLTWRPDGSVRIGALTTVAELAGDVRLRADHPALALTAQALATPQIRAVATVGGNLLQRNRCWYYRNPAFSCHQNGGDSCPARAGLTLYSAVIDTGPCVAPHPSSLAMALLACEASVEVHGRGPSPVGDLYGDGSDPARDHLLGPGEVLVAIDLPPPVPGERAAYHRAIGRSEAEWPLVEAVARLAQDGGGIARAAVAVGGVARTPLRLPEVEEALLAGEPLDRAAARAAARCTPTAQNGYKVALLTGTVLEVLERAAGAAEGGS
>NC_013595.1|WP_012892109.1|6155486_6156740_+|serine-hydrolase
MTTLSRRNLLKASAGFVPAVALGTRPAQAAPVPVVTTSGIAPAALAGFDKVMKTFVTERNISCAQLAIAKKGKILLARGYRYSDGSQAIPSVTPTSLFRIASLSKHITATAIMRLVQDGKLSLAAPVTTLLGLSAEADPRLAQVTVLRLIQHLGGWDRNVSKDYLYLDHQISATLDAPLPISQEDIIRYAGARPLDFAPGARMAYSNYGYMLLGRIIEKVSGTSYESYVKQKLLAPVGITRMRLGRVLRSEAALTEVVYSSQYTGKTVTDDSGTVVPTPYGGFSMANRGAGGGWLASAVDLVRFSRVFDAAGPVLNAASIGRMFAKPEIGVNENGSWYGGGWWVRQVPGNLNTWHDGSLPGTYTYLARLQNGFTYAALFNRREEEGTLDFDVLSPRMNAELNKVTTWPTTDLTPKYF
>NC_013595.1|WP_012892108.1|6154730_6155411_+|response-regulator-transcription-factor
MIRVLVADDQALLRGSFRVLVDTAPDLTTVGEAGTGVEAVGLARSERPDVVLMDVRMPEMDGIEATRRICGSADTAGVRVLMLTTFDLDEYVYAALRAGASGFLLKDTPPGELLAAIRVVAAGEGLLAPTVTRRLIAEFARRPEPSQPLAGELGGVTGRERDVLALIARGLSNTEIAGHLRLSLATVKTHVGRLLSKLGARDRAQLVILAYETGLVSVASRRPRQG
>NC_013595.1|WP_043656796.1|6152344_6153286_-|ATP-binding-cassette-domain-containing-protein
MIEVKELTKRYGATVAVDGLSFQVTAGLVTGFLGPNGAGKSTTMRVLLGLDAPTSGEGLVNGRRYATIRHPMHEVGALLDADAVHAGRSAFDHLRCLARSNRIGGRRVAEVLEQVGLAGVARKRAGGFSLGMRQRLGIAAALLGDPGVLMFDEPVNGLDPEGVRWIRHLMRSLAAEGRTVLLSSHLMSEMALTADRLVVIGRGRLITETSVQDLADRFERGVLVRSPRAAELTAVLRAAGATVLVEPDGGLAVKGLEVAEIGDLAAGHGLAVHEVTPRSASLEEAYMELTGDSVEYRAAGGSGDGGGRQGAGR
>NC_013595.1|WP_012892105.1|6151550_6152348_-|ABC-transporter-permease
MTDVLASEWLKLRSARSTWYILGVVVAFVLLMAGFAFYVVSLWEGMPPERRAGLRAAQPEQVVLLPLQICAAVLGVLTITSEYATGMIRSSFVAVPRRGTVLAAKAAVVAATTLVIGQASVFVTFFAGRAIAGDRPIRDFAPTLAGELPKMLATGLSPMVLALVGLGLGAVLRSTAGTVASVVALLYVVPRFALALPDPWNARVGSVLPEDLTRQLAGEAPMAVDLGDSASAIGLSPPMALAVMALYVVVALGAAAAVLGRRDVR
>NC_013595.1|WP_012892104.1|6150783_6151554_-|ABC-transporter-permease
MTDVLASEWLKLRSVRSTWYILGLVALAVPLVAFLTLQGVNGWDGLSPGRRARFQAPPMEQALLPLVQLCMGVLAVLAITSEYTTGMIRTSLAAVPRRRRVLGGKAVITAGISLLGGLLFLFGAFAVSRAIVGDRPMSPGYTTPPEAEVPMLLASGLSVAVIALVGLGLGAATRSAAGAIVALSGLLFVLPVLAGLLPGPWSGRVGSVLPANLAGQLVDHPSAVGDLPPLGALGVLVAYAVAALGAGTAVLARRDA
>NC_013595.1|WP_012892103.1|6150068_6150635_+|hypothetical-protein
MTVTGRVTGSGSPLIRRGDVTGAAAPGRPAGHTPAETAALLDLLTAARPRVETVTVGHGRDDASRAAAQAFVRSWEGAGGTVQAVVDWPEEAASWLRPARRFAAGDPDAWVVTGAAAGWAQMSRRLRHSTGWEPRRTYGFACLGDVRVVRLAGPGTLEGMRGVAADGSTWQIGRGLITYYPAPGESPR
>NC_013595.1|WP_012892102.1|6149261_6150014_+|2OG-Fe(II)-oxygenase
MNTPSRQTGGTVTAEADLATRVGRVDWAGVTDEVNAHGCALTPRLIGPAECADLSALYEEAGRFRSTVDMARYRFGSGQYRYFDSPFPEPVRQLRQAFYPRLLPIARDWAAKLGRSAPWPDTLDEWLEMCHAAGQTKPTPILLRYRQGDWNALHRDLYGDLVFPLQVVIGLDEPGVDHTGGEFLMVEQRPRAQSRGTSTLLRQGHGLVFTTRDRPVESARGWSAAPVRHGVSTVRSGIRHTLGLVFHDAA
>NC_013595.1|WP_012892101.1|6147844_6149026_-|MFS-transporter
MPLALLALAIGAFGIGTTEFVIAGLLPEVARDFGVSIPTAGYLISGYALGVAVGAAPMTVLGTRMRRKHLLLALMVIFILGNVLSALAPTYGLMMTGRIVASFTHGAFFGVGAILAGDLVAPGRRASAIALMFTGLTLANVLGVPMGTFIGQAFGWRVTFWVVAGLGVVGLLSIAALVPVQPRPASTDIGAELAVFRSPQVWLAIGMTVLGFGGVFASFTYIAPMMTEVAGFSEGAVSWLLVLFGIGLVIGNLLGGRLADRALMPSLYALLAGLALVLAVFTFTSHARIPAAITVFLLGAFGFATVPPLQKRVLDNAAAAPTLASAVNIGAFNLGNALAAWLGGLVITAGLGYTAPNWVGALLAAAALALAALSGLLERRTVAAAPRPEMQPV
>NC_013595.1|WP_148269680.1|6146090_6147590_-|carboxylesterase-family-protein
MAGEVVATTGGRVRGRRVAGGVRATLGIPYAAPPFGAGRFREPRPASAWSGVRDCDRFGPVAPQSARLPGAPAWSPGQDDILSVNVWAPERAPGPLPVLFWIHGGAYTFGSSAQPEYDGAELARAGLVVVTCNYRLGFEGFGHVPGLPANRGLLDQVAALHWVRDNIADFGGDPGNVTVAGQSAGAGSVACLLTMDRARGLFRRGIAHSVPDAYYPPGLAAGLTRKVAAAAGIPATAGGLLSAAPHALVAASDRVVQGYRADPASGPLHYDTVIYGPVLDGDVLATDPLSALSAGTVREMDLLFCHTTQESWLMHRTGSMPPVTDEEGLARFAADFGLPDALVAGYRALLPDAPVLEVYLAMAGDAVFAEHTAGLAGAHARAGGRAFLSRFARCRTSPDGDTVRPWHAADVPFASGNLDAVGVDFLIGGVPDGQDRALSRRMVRAWADFCATGDPGWSRLTTSSAPVRSWGVPEDRVAEDDAAAVHALWRGVIPSRLRL
>NC_013595.1|WP_012892112.1|6160359_6160902_+|TetR/AcrR-family-transcriptional-regulator
MGDVVDDTRTRLVESALRLLREEGLDAVTLRAVGDLTGLSRMAPYRHFADKTALLAALAVRVIVDLSAHVAGAVLEGADRRERLRAFYTSYVEYAMEHRNEYRLVFASEFLIGHHPELERAIDDVMTALGLKTSGGQAASKAGAMALLSTAHGLAELATAGHFAQKGISYEDVIDVLVAP
>NC_013595.1|WP_012892113.1|6160956_6161643_-|HAD-family-hydrolase
MDYPELPGPAFLFDLDGTLIDSVYQHVIAWRSALSRLGIDLSVWRIHRRIGMSGGLFVSALLRETGLSLTRSQIDELQQAHADAYTEQLDSVRPLPGAADLLAELTGRGVPWAIATSGYARTARPALGMLGLPEDTPMVTRDLVRRAKPDPDLFLAGAALLDVDPRYAMVVGDSVWDLLAARRAGALGIGLLSGGYGRDELERSGAFRVYADPADMRNRLDELGVRLD
>NC_013595.1|WP_063610295.1|6161835_6162192_+|helix-turn-helix-transcriptional-regulator
MFDPACPSSITPIRIGDKWTAMIVICLEDGPRRFSELLVPLHNITPKVLTETLRALERDGMVTRTAYPEIPPRVEYALTPLGRSLLDLVDACRTWGDKHLSQLIEARDAYWQRVDSGR
>NC_013595.1|WP_012892115.1|6162267_6163815_-|SDR-family-oxidoreductase
MRCLVTGATGYIGGRLVPELLDAGYDVRCMVRSAGRLRDQPWASRVEIAEADAADAVRTGKALDGVEVAYYLIHTMGGGADFAAADRHAAATFAAAAREAGVRRVVYLGGLAPDEELSPHMRSRAEVGEIFLRSGVPAVVLRAAVIIGSGSASFEMLRYLTERLPVMTTPRWVRTRTQPIAIRDVLRYLVSWAAIEGEVNRSFDIGGPDVLTYADMMRVYTEVAGLPRRVIIPVPMLSPGLSSHWVGLVTPVPAGIARPLVESLRNEAVCREHDIAGYVPDPPGGLIGLREAVALALRRIREAKVVTRWSSASTPGAPSDPLPTDPDWAGGSLYVDRRARRVDASPQALWAVIESIGGERGWYSLPVAWRARGLLDRLVGGVGLRRGRRDPRRLRVGDAVDFWRVEEVEPGRLLRLRAEMRLPGLAWLELSVHRHRGRTVYGQRAIFHPRGLAGHLYWWSISPFHTLIFGRMTRNVAAAAERGDTSPTPAPATGGISGADPSTPPRRDPRDTVAT
>NC_013595.1|WP_012892116.1|6163875_6164781_-|helix-turn-helix-domain-containing-protein
MITPHAGGEPVRPTPMALPRGSSTVLRIVLGAQLRRLREQRHITLEEAGHAIRASHSKISRMELGRVSFRIRDVADLLTLYGVTDDDDRQSLLALVERANVTGWWHNYNDILPSWFETYVGLEESATGIRNYEVQFVPGLLQSEGYARAVVRLGFPAAPEEEVERRVRLRLARQRLLRGAEPPHLWAVLDEAVLRRPLGGAEVMRDQIDHILRALELPNVTVQIVPFSVGGHAAAGGPFSILRFSQPDLPDVVYMEQLTSAVYLEKRDDVDRYLEVMERLCIEAEPASRTREILTRIREEL
>NC_013595.1|WP_012892117.1|6164906_6165143_-|DUF397-domain-containing-protein
MNQPHNGMPATLLDGIVWRKSHFSNPSGNCVELAALPGGGVAIRNSRDPEGPALIYTRRELDAFVRGVKGGDFDDLII
>NC_013595.1|WP_012892118.1|6165381_6165885_+|ATP-binding-protein
MLDHVLPPSGLPPWADGDSHIDHLQMAVRSLRHDPRAARTAREFTSAALRSWELAPLIDDTGVVVSELVTNAVRHGVRDGGGGRSAQDVRVILCHTERSVLCAVTDPSDQGPSLREPDYEAENGRGLQLVQGVSEMWGWAPLESRGKAVWAAFAVPSRAARHLEACH
>NC_013595.1|WP_012892119.1|6166027_6166843_+|SAM-dependent-methyltransferase
MVPPKTERLTFDPTVPNAGRIADYFLGGKDNFAADRAAAQLALALAPELPAMTREGRRFLGRAVRFLAESGIRQFIDIGCGLPTQGNVHEMVHAVAPDARVVYVDNDPMAVVHAQALLQDDLLTTVVEADARDPERLLSDPRLTGMIDLDRPVAVLLFSVLQDVTDDVLAMQIVTDLQKAIAPGSYLAVSHAVSDLCPETTAKLAALYQDRGSVTGPRRDNLRTIADVGRFFDGLTLVDPGLVYVPRWRPDGIVLHRPDSVWVVGGVGRKE
>NC_013595.1|WP_012892120.1|6166966_6167785_+|SAM-dependent-methyltransferase
MSDATRRPPAGLDTSVPNVARMNDYFLGGKDNFAADRRAAEEVLAIAPEIRTMAKEGQAFLGRAVRHLVEQGITQFLTIGSGLPTQHNVHQVARSLEPAARVVYVADDPVVLSHSLALLATDPRTAVVRGDVLHPDELLADPELRRLIDLERPVALLITSALQFIPDEDDPFKSVARLRDAVAVGSHLVIAHAVFDTRPEAAGPLVDIYRKVLGRSEDASRTRTQVLRFFDGLELVDPGLVYIRQWRPDNPLAARRPERTWTVAGVARKTDA
>NC_013595.1|WP_012892121.1|6167866_6169504_-|ATP-dependent-DNA-helicase-RecQ
MGVRDGFGLRARRLRAVARKVFGWRDLRPGQLEAMRHLLGGGDALVVMPTGSGKSAVYQVPALLLDGPTVVVSPLIALQRDQVAGLREADAGGAVAVNSAQSGTEASLESVRAGTTEFVFLSPEQLARPETVERLRAARPSLIAIDEAHCVSAWGHDFRPDYLRLGQVIERLGHPPVVALTATATPSVREEIVTALGLSDVRQIVRGFDRPNLDLEVRRFVTQEDLRRALVEDAASRPGLGLVYVATRRAAEEYAAALREAGRRVEPYHAGMKAADRHRVHGMFRDDELDVVVATSAFGMGIDKPDVRFVLHAAPPESPDSYYQEIGRAGRDQAPASAVLFYRPEDLGLRRFFAGGRADEELLLRTATLIHEHGGAVPAADLRAVLDVGATRLTRVVNLLERAGAVEVTGEGDLRQVSGGPAPREATARAVELDDTRRRIDDSRIDMMRGYAETTGCRRRFLLEYFGEPYERTCGDCDTCRAGLSAPPETGGGPFPMHAGVRHSSWGAGVVMSREADRITVLFDEVGYKTLSLEAVERDGLLEAC

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Crispr_ID: NC_013595_33

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_33

6178653-6178768

Orphan

Consensus_repeat	Method
CCCGGGGACGGAGGGTCGCGGACGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_33

>merge|NC_013595|33|6178653-6178768|CRISPRCasFinder
ACACGGGGACGGGGGTCGCGGACGGCGGCCCCGGAGCCCCGGGGACGGAGGGTCGCGGACGGCGCCCCGGGGACGGGGGCGGACGGCAACCCGGGGACGGGGGGTCGCGGACGGCG

>NC_013595|33|31|6178653-6178768|CRISPRCasFinder
ACACGGGGACGGGGGTCGCGGACGGCG	GCCCCGGAGCCCCGGGGACGGAGGGTCGCGGACGGCGCCCCGGGGACGGGGGCGGACGGCAA
CCCGGGGACGGGGGGTCGCGGACGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_174435262.1\|6187264_6187945_+\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NC_013595.1\|WP_012892132.1\|6180088_6180625_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223508
NC_013595.1\|WP_012892129.1\|6177489_6177996_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012892128.1\|6176554_6177427_-\|lipid-kinase	unknown	unknown	gnl\|CDD\|224513
NC_013595.1\|WP_012892123.1\|6170488_6171712_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366721
NC_013595.1\|WP_012892135.1\|6182736_6183501_-\|ABC-transporter-permease	unknown	unknown	unknown
NC_013595.1\|WP_012892136.1\|6183497_6185054_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|377771
NC_013595.1\|WP_012892133.1\|6180822_6182037_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NC_013595.1\|WP_012892130.1\|6178113_6178584_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380340
NC_013595.1\|WP_012892126.1\|6174161_6174560_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|259860
NC_013595.1\|WP_043653047.1\|6172503_6172686_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012892140.1\|6188000_6188144_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012892137.1\|6185050_6185968_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NC_013595.1\|WP_012892124.1\|6171850_6172486_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012892134.1\|6182122_6182575_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_013595.1\|WP_012892125.1\|6173008_6174025_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_013595.1\|WP_012892131.1\|6178968_6179862_-\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274681
NC_013595.1\|WP_012892127.1\|6174799_6176437_+\|alpha-D-glucose-phosphate-specific-phosphoglucomutase	unknown	unknown	gnl\|CDD\|236050
NC_013595.1\|WP_012892138.1\|6186083_6187268_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NC_013595.1\|WP_086012430.1\|6169615_6170170_-\|fasciclin-domain-containing-protein	unknown	unknown	gnl\|CDD\|367095

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_174435262.1\|6187264_6187945_+\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	7.68524e-66
NC_013595.1\|WP_012892132.1\|6180088_6180625_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223508	COG0431, COG0431, Predicted flavoprotein [General function prediction only].	2.69536e-17
NC_013595.1\|WP_012892130.1\|6178113_6178584_-\|cupin-domain-containing-protein	gnl\|CDD\|380340	cd02210, cupin_BLR2406-like, Bradyrhizobium japonicum BLR2406 and related proteins, cupin domain. This family includes bacterial and fungal proteins homologous to BLR2406, a Bradyrhizobium japonicum protein of unknown function with a cupin beta barrel domain. Proteins in this subfamily appear to align closest to RmlC carbohydrate epimerase which is involved in dTDP-L-rhamnose production, and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	7.12161e-35
NC_013595.1\|WP_012892128.1\|6176554_6177427_-\|lipid-kinase	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	1.0184e-42
NC_013595.1\|WP_012892123.1\|6170488_6171712_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|366721	pfam01593, Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	9.48925e-37
NC_013595.1\|WP_012892136.1\|6183497_6185054_-\|ABC-transporter-permease-subunit	gnl\|CDD\|377771	pfam07081, DUF1349, Protein of unknown function (DUF1349). This family consists of several hypothetical bacterial proteins but contains one sequence from Saccharomyces cerevisiae. Members of this family are typically around 200 residues in length. The function of this family is unknown.	3.61859e-06
NC_013595.1\|WP_012892138.1\|6186083_6187268_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.2622e-39
NC_013595.1\|WP_012892133.1\|6180822_6182037_-\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.65545e-46
NC_013595.1\|WP_012892126.1\|6174161_6174560_-\|hypothetical-protein	gnl\|CDD\|259860	cd00920, Cupredoxin, Cupredoxin superfamily. Cupredoxins contain type I copper centers and are involved in inter-molecular electron transfer reactions. Cupredoxins are blue copper proteins, having an intense blue color due to the presence of a mononuclear type 1 (T1) copper site. Structurally, the cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel. Some of these proteins have lost the ability to bind copper. The majority of family members contain multiple cupredoxin domain repeats: ceruloplasmin and the coagulation factors V/VIII have six repeats; laccase, ascorbate oxidase, spore coat protein A, and multicopper oxidase CueO contain three repeats; and nitrite reductase has two repeats. Others are mono-domain cupredoxins, such as plastocyanin, pseudoazurin, plantacyanin, azurin, rusticyanin, stellacyanin, quinol oxidase, and the periplasmic domain of cytochrome c oxidase subunit II.	0.00279426
NC_013595.1\|WP_012892137.1\|6185050_6185968_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	9.89433e-87
NC_013595.1\|WP_012892134.1\|6182122_6182575_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.18637e-30
NC_013595.1\|WP_012892125.1\|6173008_6174025_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.53725e-76
NC_013595.1\|WP_012892131.1\|6178968_6179862_-\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274681	TIGR03620, F420_MSMEG_4141, probable F420-dependent oxidoreductase, MSMEG_4141 family. Members of this protein family, related to F420-dependent oxidoreductases within the larger family of a bacterial luciferase (an FMN-dependent enzyme), occurs only within the small subset of species that synthesize F420. Most such proteins are from members of the Actinobacteria, but at least one species, Sphingomonas wittichii, belongs to the Alphaproteobacteria. [Unknown function, Enzymes of unknown specificity].	4.13138e-107
NC_013595.1\|WP_012892127.1\|6174799_6176437_+\|alpha-D-glucose-phosphate-specific-phosphoglucomutase	gnl\|CDD\|236050	PRK07564, PRK07564, phosphoglucomutase; Validated.	0
NC_013595.1\|WP_086012430.1\|6169615_6170170_-\|fasciclin-domain-containing-protein	gnl\|CDD\|367095	pfam02469, Fasciclin, Fasciclin domain. This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.	1.61361e-40

>NC_013595.1|WP_012892130.1|6178113_6178584_-|cupin-domain-containing-protein
MAIILPEDPFHRRLHHITPGGLTSETAQTGGMHRRAAISGATVGSSRLWMGQTHVAPATVSANHHHGESETAIYVVSGTPSFVFVDIDAEEPVEVRVDTRPGDYIFVPPYVPHREENPDPDHEAIVVIARSTQDAIVVNLDGLEWTGPVLTTGRPG
>NC_013595.1|WP_012892129.1|6177489_6177996_-|hypothetical-protein
MDDSGEERALRALGAALDASAPAVRHGRGEFPEGTPFLWLGFPGAGEAAVFAHGRQWICLSEPEPGGVATQLVAGRLDEDPALVAERLMSVMVPVRGRTDGLYRVLKACGIGLAAGLGMGMLGLVIMAILVGGNGYLSDTSTAAVYVLAALLGAGTGLWLGVRWWRLG
>NC_013595.1|WP_012892128.1|6176554_6177427_-|lipid-kinase
MAELLAIYNEEAGGVDDAARTAVMEVLRGGADVVEVPAGQKDLDEMLDAHPGRDVVVLGGDGSLHVTVAALHRRGELDARTVGLVPLGTGNDFARGLGIPLDPEVAARIVLAGRPHPLDLLVDGEGGIVVNAVHLGVGAEASEQAKPLKPKLGRFAYAVGGLLAGVRSPGWRLRVTVDGRPLAEGRPVLMVGIGNGVTIGGGTPLTPRARPDDGMVDVVAALTTGPVERLVYALRLRRGTHPELRDVVTGRGREVVVEGEPVPVNADGELTGPVTRRRWTVAPGAWRMFT
>NC_013595.1|WP_012892127.1|6174799_6176437_+|alpha-D-glucose-phosphate-specific-phosphoglucomutase
MTHERAGKIAQPSDLVDVARLVTAYYALHPDPQEAGQRVAFGTSGHRGSSLNVAFNEDHILATSQAIVEYRAAQGVDGPLFLGADSHALSEPAQVSALEVFAANGVRVLIDSRDGYTPTPAVSHAILARNRGRAAGLADGVVVTPSHNPPGDGGFKYNPPNGGPADTDATSWIQDRANALIAGGLKEVRRIPYARALAADTTGRHDFLGAYVDDLPSVLDIDAIREAGVRIGADPLGGASVAYWGEIAERHRLDLTVVNPLTDPTWRFMTLDWDGKIRMDCSSPYAMASLIAGRDAFDVSTGNDADADRHGVVTPDGGLLNPNHYLAAAISYLYSHRPDWPADAGVGKTLVSSGMIDRVAADLGRRLMEVPVGFKWFVPGLLDGSLGFGGEESAGASFLRRDGSVWTTDKDGIILALLASEIIATTGRSPSEHYAGLVSRFGDPAYARIDAPATREEKAVLGRLSAEQVTADTLAGEPIREVLTSAPGNGAPLGGVKVSTDSAWFAARPSGTEDVYKIYAESFKGPEHLAEVQEAARDLVSESLK
>NC_013595.1|WP_012892126.1|6174161_6174560_-|hypothetical-protein
MFAAIRSGGRPRLATGFAAAALALAACGGTTTAVMPPAWASDTPVKVVASEFSLALSEKNFRPGTYTFELDNVGAAPHGLSIKGPGVSSTSAVVPGGKSAKLTVTLRKGMYELWCPVGNHRARGMMTTISVK
>NC_013595.1|WP_012892125.1|6173008_6174025_+|LacI-family-DNA-binding-transcriptional-regulator
MKRPTIADIARRAGVSKVAVSYALNGQAGVSEATRATIMAIAAEIGWRPNSAARALNGARAHTIGLALCRPARVLGMEPFLMELISGIEGELSVRSYALMLQIVADHDQETAVYQRWWGEGRVDGAFLLDLHFADPRVTGLETLGMPAVVIGHPSESGSLASVWSDDGAAVRETIEYLAALGHRRVARVAGLPKLVHTAMRDRAFTASCDDLGLTGHVTVHTDYTGEEGAWATRRLLSSPARPTAIVYDNDITAVAGLSVAQEMGLDVPRDLSIVAWDDSPLFQVVRPPLTALSRDIAAYGAHAAQRLLALIDGGTASAFEDRAARLTPRGSTGPPPA
>NC_013595.1|WP_043653047.1|6172503_6172686_+|hypothetical-protein
MRWWKILGLAGVAGVAATGVVIARAERRRQAYTPDEIRERLRARLEEASESERKALGQTP
>NC_013595.1|WP_012892124.1|6171850_6172486_-|hypothetical-protein
MPGKSISLDEAVNLTRTGDVWLFRGRTVPDRAIQTVTNSPVNHVGMSVVIDDMPPLMWHAELGRSLPDLWSGTHQRGVQLHDLREAVCVWATRYGQRGWLRQLEPQVTREMEDAVLRTVARLDGTPFPSTARLAGRWFRGRVPKLLKRGAEESALESAYCAEVVAVTYEAMGLLPGGRRPNWYDPGRFWSGDDLELSGGFQLGGEITVKLE
>NC_013595.1|WP_012892123.1|6170488_6171712_-|FAD-dependent-oxidoreductase
MSDTVVVVGAGLAGLSCAVRLHAAGVPVRVVEAAGEVGGRVRTDIVDGFRLDRGFQVFNTAYPEAGRVLDIGALDLGVIASGLIVFERGRRERFMLPWRHPGHALSGLLADVGSPRDKAALAALTAWDIAVPAERLRGGTERTTEAELRHWGISSRMIDKLLRPFLSGVVLERELQTSSRFFHLLWRAFARGTIGLPALGMGEIPRQLAARLPAEALSLGTPVAAVTEDGVRTAGGEAIPARAVVVATDPAAAAGLCPGLRIPEMRAVTTFYHVAARSPLGEPTQIVDAEGLVTDTLVVTDVVPGYSPDGRALISTSLLGVLSDADEPGVRSRLAQIYGTDTSAWRHLATYPIEAALPAMTPPFPLRRPVRLAPGRYVCGDHRDTGSQQGALVSGRRAADAVLADLG
>NC_013595.1|WP_086012430.1|6169615_6170170_-|fasciclin-domain-containing-protein
MPTDMTSESPTDMTSESPGAMTKPFGPGCSSLPTTGEGSPENMAKEPVATAASYNTQLSTLTEAIKKAGLVDTLNSAKEITVFAPTNEAFSKIPKEMLDKVLADKAQLTKILTYHVVEGRKAPAELTDATLSTLAGGTLTVKGSGEDYTVNDEAKVLCGNIQTANATVYLIDAVLLPTAGATPS
>NC_013595.1|WP_012892131.1|6178968_6179862_-|LLM-class-F420-dependent-oxidoreductase
MGIGRIGVWHPLLGRASAPSVRRAAVAIEALGYGTLWFGEAPGTREAFSAAGILLAATERISVATGIANIWARDATAMAAGGKAYGEAYPGRFALGIGVSHAPLVSRRGHDYARPLAAMRAYLDAMDIAAADMMLVDNPPAPRLLAALRPRMLELARDRADGAHPYFVPPEHTALAREILGSAPILAPEQAVVLERDPARAREIARAHMDPYLKLPNYVNNLLHLGYEDRDFTGGGSDRLVDAIVAWGDAEAVARRIGAHLDAGADHVAIQPLPTDLRGGVDQLTELAPALGVRSGE
>NC_013595.1|WP_012892132.1|6180088_6180625_-|NAD(P)H-dependent-oxidoreductase
MKIIGIAGSLRPGAYIRKLLEASARELPTSVDFEIWDGLDQVPPFQEGPLPQRVDELCHILSGADGLLVAAPAHSILPPQLGHALAWAASSRGGAVLVGKPAVVLTACLHAHEATWTQTELRRALGAAGAVVYGADLVVSSALSQFDSEGRLVDPEFRVRLCGVLEGLCKPSFTKSTV
>NC_013595.1|WP_012892133.1|6180822_6182037_-|MFS-transporter
MSSGLTGRQRALLALVCAVAVSAIYGIQPVLEAAGEDLGLSKGTLGWLVAAGQIGYLAGLVLLVPLGDLFDRRGLITVHLLLTAVGAGVAAVAPGGGIAIAGLALAGLFAVVVQTTVAYVAAVSPAGERGRNIGAVTSGVVIGILGVRVVAGTLGELADWRMVYLVIAGLCAMLALAARFTLDADIRRPRARYGQLLSSLGRLVAGDRLFLGRGLVAFFLFASFGTLWSGLALPLGDAPWHFGTTEIGLFGLAGLIGALGAARAGRWADRGLAPSVTGWSLALLTASWLLIAQAGSSLWLLIVGVIVLDFAVQAVHVSSQHLLTTARPDRSSSVIGAYMAFYSLGSALGAITTTWAYSAAGWSAASLLGAAYAALALLVAVSTRRLTVLPRAQQPGASVSAASR
>NC_013595.1|WP_012892134.1|6182122_6182575_+|helix-turn-helix-transcriptional-regulator
MDVTLAAGSAWTDPACPVARTVDLIGDRWSLLIIRDAMDGATTFTEFHQRLGIARNILTDRLRKLVEHGILDRSAASDGRRHTYRLTEAGQDLFTAVVALRQWGERHAFAPGEPHSVLVDGQGRELPELHPLGQDGTPLSAEASHVRKTA
>NC_013595.1|WP_012892135.1|6182736_6183501_-|ABC-transporter-permease
MTQHLYAEWTKLRTLPGTGRLLLALVMLTVAVSVAAAAVVSCTLSVCGYDPAKISLFGIQAGQAVVAILAVAAISGEFSTGMIRTTLAAMPGRIGVLAAKAVILTGLTLAAGSVAVLASALAGQRILLDNGFTPESLALTSGPMLRAAFGSVLYLALIALFSLGIATAVRDSATAIGVVLGLLYLFPAIILMAPDADVAELLWQISPMNAGLAVQATTHLSSLPLSPWAGLGVLAAWATAALLCGGLLLRARDA
>NC_013595.1|WP_012892136.1|6183497_6185054_-|ABC-transporter-permease-subunit
MTATVNRSGPGGPARLLRAEWTKFRTVRAWVIAMTAGALVIVLLGLSSASGSHASCAGGPTEAVCPAVPVGPGGEAVEDKFYFVHRTLAGNGSITARATSMTGRIRKPDVTPGVRNVVSGLVPWAKAGVMVKQSTRQGSAYAALMVTGAHGVRMQHNFTHDVAGRPGGVSEDSPRWLRLTRSGDTLTGYESTDGTDWAGVGTARLSGLPATVEIGLFAASPGDLTVTQGDLGGSVSAARFTEATAVFDQVGLEGETSGGAWRNDDIGVTKAPDGSAHHPGRAGESGGTFSVTGVGDIAPSIEGQTIERTLTGVLTGLIVVIVVAVMFVTAEYRRGLIRTTLIAIPRRGRMLVAKALTIGTVTFVAGLAATAITLTFGTRILRANGNHILPVSWLTEVRVVVGTAALLAVAAVLALALGALFRRSVGGVITAIVLIVVPHVLATTSVLPDTAARWLLRLTPAAGFAIQQSIPEYAHVLGHYAPIAGFYPLAPWAGLAVPAGYAALALGLAVVQLRRRDA
>NC_013595.1|WP_012892137.1|6185050_6185968_-|ATP-binding-cassette-domain-containing-protein
MQATIEVSGLRKRFGRTLALDGMSFTVQPGRVTGFVGPNGAGKSTTMRVILGLDAAEEGHALVGGRPYPSLRTPLRHIGALLDAAALQPGRSARNHLLWLAHSQGLGVRRVDEVLEQVGLASAARRKAGGFSLGMRQRLGIAAALLGDPPVLMLDEPVNGLDPEGIVWIRGFLRSLAAEGRAVLVSSHLMSELQDAADHLVVVGRGRVITDTSVADLIAATSSGRVTLRTTARGPAMSALARAGAIVTVTERDTLIVSGLPGEHVVALLNAGAVPFSEVSAHRATLEEAYLELTRDAVEFRGATR
>NC_013595.1|WP_012892138.1|6186083_6187268_+|HAMP-domain-containing-protein
MPRRPALPTRTVRWRFTVMYGGAFLVSAVGLLVITNLIGLSGTRVSETAPLGDPPGQPTLAAAQDLIGRLQAQLSETQTAQSRRLLIGSAVALAVMAVLSVVLGRIVAGRVLRPLRTITAATRRISADNLHQRLAVPGPADEVKDLADTIDGLLERLEGSFAAQRRFVANASHELRTPLATMRASLDVAIAKPEPVPAQTIALADRIRTELDQVDRLLEGFLMLARTQHGALSDRATISLGRVVSAALDARAADITDRSLTVHHGDVHDSAWTRGSRTLLSRMVDNVIDNAVAHNHDGGWIRVAATADGATARLIVETGGRVLDQEQLARLAQPFQRLGADRTGSGNGSGLGLSIVAAVATAHGGSLDLRARPEGGLQVAISLPLAAVRAGVPA
>NC_013595.1|WP_174435262.1|6187264_6187945_+|response-regulator
MRVLVVEDARSLAAVLAEGLRDQGMAVDVAHDGLEAAAKLDLNAYDVVVLDRDLPGIHGDTLCQMITERDDRAMVLMLTAAGSPGDRVSGLTLGADDYLAKPFHFPELVVRIRSLTRRQPFARARTLRAAGIELDPLRRTATRDGRRLDLSVKEFALLEALLRATPAFLSTEDLLEQVWDEHADPFTNTVTVTIGRLRRKLGNPPIITTTPGIGYRITDGFHGIAL
>NC_013595.1|WP_012892140.1|6188000_6188144_-|hypothetical-protein
MHSTETKTPQVPGAQPHHEVRGKAVEFPGDHQGPAADADADADAESP

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Crispr_ID: NC_013595_34

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_34

6813621-6813719

Orphan

Consensus_repeat	Method
AAGGCCCCGGCCGTACAGGAGATCCCG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NC_013595_34

>merge|NC_013595|34|6813621-6813719|CRISPRCasFinder
ATGTCGCCGGCCGCACGGAAGGCCCCGGCCGTACAGGAGATCCCGGCCGCGCGGAAAGCCCGGATCACGCAGAGGGCTCCGGCCGTACATAAGGCCCCG

>NC_013595|34|32|6813621-6813719|CRISPRCasFinder
ATGTCGCCGGCCGCACGGAAGGCCCCG	GCCGTACAGGAGATCCCGGCCGCGCGGAAAGCCCGGATCACGCAG
AGGGCTCCGGCCGTACATAAGGCCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012892661.1\|6800457_6801105_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_013595.1\|WP_012892663.1\|6802527_6803835_+\|acyltransferase	unknown	unknown	gnl\|CDD\|376607
NC_013595.1\|WP_012892672.1\|6814545_6815757_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223717
NC_013595.1\|WP_148269703.1\|6811196_6812261_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NC_013595.1\|WP_012892682.1\|6827110_6827758_-\|L-ribulose-5-phosphate-4-epimerase	unknown	unknown	gnl\|CDD\|235829
NC_013595.1\|WP_012892679.1\|6823809_6825063_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340877
NC_013595.1\|WP_012892667.1\|6807748_6808705_-\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_013595.1\|WP_012892666.1\|6807266_6807782_+\|DUF2087-domain-containing-protein	unknown	unknown	gnl\|CDD\|378279
NC_013595.1\|WP_012892675.1\|6817840_6818560_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_013595.1\|WP_012892677.1\|6820062_6822273_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_013595.1\|WP_012892681.1\|6825632_6827114_-\|L-arabinose-isomerase	unknown	unknown	gnl\|CDD\|179503
NC_013595.1\|WP_148269247.1\|6816415_6817585_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_013595.1\|WP_012892670.1\|6812996_6813599_+\|DUF4291-domain-containing-protein	unknown	unknown	gnl\|CDD\|379483
NC_013595.1\|WP_012892664.1\|6803957_6806450_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|378795
NC_013595.1\|WP_012892676.1\|6818556_6819783_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_013595.1\|WP_012892678.1\|6822340_6823813_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|236369
NC_013595.1\|WP_012892662.1\|6801095_6802343_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_013595.1\|WP_012892668.1\|6808768_6811021_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|223256
NC_013595.1\|WP_012892665.1\|6806501_6807188_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_148269246.1\|6813773_6814355_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012892661.1\|6800457_6801105_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.01225e-42
NC_013595.1\|WP_012892663.1\|6802527_6803835_+\|acyltransferase	gnl\|CDD\|376607	pfam01757, Acyl_transf_3, Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.	1.78099e-07
NC_013595.1\|WP_012892672.1\|6814545_6815757_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223717	COG0644, FixC, Dehydrogenases (flavoproteins) [Energy production and conversion].	6.2226e-56
NC_013595.1\|WP_148269703.1\|6811196_6812261_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	1.98078e-118
NC_013595.1\|WP_012892682.1\|6827110_6827758_-\|L-ribulose-5-phosphate-4-epimerase	gnl\|CDD\|235829	PRK06557, PRK06557, L-ribulose-5-phosphate 4-epimerase; Validated.	5.70319e-154
NC_013595.1\|WP_012892679.1\|6823809_6825063_-\|MFS-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.70398e-73
NC_013595.1\|WP_012892667.1\|6807748_6808705_-\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	6.85527e-51
NC_013595.1\|WP_012892666.1\|6807266_6807782_+\|DUF2087-domain-containing-protein	gnl\|CDD\|378279	pfam09860, DUF2087, Uncharacterized protein conserved in bacteria (DUF2087). This domain, found in various hypothetical prokaryotic proteins and transcriptional activators, has no known function. Structural modelling suggests this domain may bind nucleic acids.	4.26037e-27
NC_013595.1\|WP_012892675.1\|6817840_6818560_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.06106e-75
NC_013595.1\|WP_012892677.1\|6820062_6822273_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	3.62322e-52
NC_013595.1\|WP_012892681.1\|6825632_6827114_-\|L-arabinose-isomerase	gnl\|CDD\|179503	PRK02929, PRK02929, L-arabinose isomerase; Provisional.	0
NC_013595.1\|WP_012892670.1\|6812996_6813599_+\|DUF4291-domain-containing-protein	gnl\|CDD\|379483	pfam14124, DUF4291, Domain of unknown function (DUF4291). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 190 and 214 amino acids in length. There are two conserved sequence motifs: VYQAY and RMTW.	6.00487e-112
NC_013595.1\|WP_012892664.1\|6803957_6806450_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|378795	pfam12029, DUF3516, Domain of unknown function (DUF3516). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is typically between 460 to 473 amino acids in length. This domain is found associated with pfam00270, pfam00271.	0
NC_013595.1\|WP_012892676.1\|6818556_6819783_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	9.65336e-45
NC_013595.1\|WP_012892678.1\|6822340_6823813_-\|amidohydrolase-family-protein	gnl\|CDD\|236369	PRK09061, PRK09061, D-glutamate deacylase; Validated.	0
NC_013595.1\|WP_012892662.1\|6801095_6802343_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.10702e-38
NC_013595.1\|WP_012892668.1\|6808768_6811021_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|223256	COG0178, UvrA, Excinuclease ATPase subunit [DNA replication, recombination, and repair].	0
NC_013595.1\|WP_148269247.1\|6816415_6817585_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	5.55091e-51

>NC_013595.1|WP_012892670.1|6812996_6813599_+|DUF4291-domain-containing-protein
MNMPHRQIRAAYTEKSITVYQAYDPAVAEPAVAAQRFVAPFKRERMTWIKPSFLWMMYRCGYATKPGQTRVLAIDLTRAGFEWALAHSCLSHPGRDGDQETWKERLRHSPVRVQWDPERDPHHNALPHRSIQIGLSGQAVDRYLDDWTVSITDITDRVRDVHTALRDGRDVTALLPPERPYPVPVELARTIGATAGGDAG
>NC_013595.1|WP_148269703.1|6811196_6812261_-|tRNA-dihydrouridine-synthase-DusB
MAGITNAPFRTLCREQGGGLFVCEMITTRALVERNAKTFKMIRFEPAEKPRSIQLYGVDPVTVGKAVRMIADEDLADHVDLNFGCPVPKVTRRGGGSALPYKRNLLRAILREAVRNAGTLPVTMKMRKGIDDDHLTYLDAGRIAVEEGVSAIALHGRTAVQHYGGTADWEAIARLKEAVTEIPVLGNGDIWSAADALRMMDETGCDGVVVGRGCLGRPWLFRDLAVACEGGRERLRPPLGEVAATMDRHATLLAECFGSEPHAVADFRKHVGWYLKGFTVGSDLRRRLATSVTLAGLREGLAELDAAQPWPEGADAPRGKSNPRDRVHLPAGWLDDPYDLAVPGADAELDTSGG
>NC_013595.1|WP_012892668.1|6808768_6811021_+|excinuclease-ABC-subunit-UvrA
MSHIEIKGARENNLKNVSLRIPKKQITVFTGVSGSGKSSIVFDTIAAESQRQLNETFSTFIRNRLPKYGQPDADGIENLSTAVVIGQQRIGGNSRSTVGTITDILSLMRLLYSRIGTPPAGYSNAFSFNDPAGMCPECQGVGRKVVLDVERAFDRSKSLNGGAILLPGFRVGTWYWKTYIHSGLFDNDKPLEDYTEAEWQTLLGGTGPDVMFETQGGTVPQKYEGVVDKFYRLQINRDTEGKSGLDSVMEFVSARRCPLCEGARLNQAALACRVDGRNIAELASMEARHLVDVIAGITVPVAATMVAAILERLRHLISIGLGYLSLDRATSTLSGGESQRIKMVRHLGSSLTDMTYIFDEPTVGLHPRDVTRMNNLLRELRDKGNTVLVVEHDRDVIEIADHVVDVGPHAGAHGGEIVYEGGVAGLHRAGTLTGRHLRHNRPLKAEFREPAGALTVAGATAHNLKDVTVAFPTGVLTVVTGVAGSGKSTLVNKVFLERHPDAVVIDQSAVSRSIRSNPATYTGLMDEVRKLFARAGGVSPALFSFNSKGACPECQGLGIIYTDLAFMDGITSTCEVCQGRRFREEVLRHTLRGRSVLDVLEMTAGEAAEFFTEPKPLRILRAVNEVGLGYLKLGQPLNSLSGGECQRIKLAGELHKTGSVYVMDEPTTGLHMSDVKHLLAIMDSLVDAGNSVIVIEHNLDVVKHADWIIDLGPDGGDRGGTVVFEGTPRQLLDVTGSFTAEYLRRDLSQP
>NC_013595.1|WP_012892667.1|6807748_6808705_-|YafY-family-transcriptional-regulator
MADTTARVLRLLSLLQAHREWPGPELAGRLEVSPRTLRRDIDRLRELGYPVHATTGPAGGYRLEAGTAMPPLLLDDEEAVAIAVGLRTAASGGVTGIEETSLRALAKLEQVLPSRLRRRVNTLQTQTVAVRGWWPTVDPDTLALLAQASRDHERLRFGYRRRDGTESARLVEPYRLASTGRRWYLVGWDTDRRDWRTFRVDRLTSPLATGARFSPREPPPGYVEESVVAPISRYRAVVTLYAPLEVVADRFSAPGAMIEALDEHSCLLRTGGDSLEWLALTIGMLGLDFTVHDPPELADYVGLLAARLQASTAPPLRQ
>NC_013595.1|WP_012892666.1|6807266_6807782_+|DUF2087-domain-containing-protein
MNDDAIRQVLGLLYQKDTLRVLAALALDGTPEDAGLGKDPTRQALDRLERGGLAVRDDDGRWQARRERFRELLHAAARPAVPLSPEEKVLQSFLVEGRLRAIPTKRDKQLIVLNYVAQVFEPGVRYPEKEVNTALRAFHDDYAALRRYLVDDGLLSRENNVYWRSGGAVDA
>NC_013595.1|WP_012892665.1|6806501_6807188_-|hypothetical-protein
MSRKIIFTAALLAGTALAGASPASAAAPAVPKGFLLHDREVATDQAKKDEPADAENVWRASAKVGERFAADFCAHDTVIASLPKDRIGQTGRAAARTVYLDVKGETETAEQVILYRSEQAARAALGQFRAAVEKCRQSEVWKSGSYSRTLARVALGDEAWKSSAREYEDGGPVAGDDVVIARRANAVIVYLASASAKPSARSYTQQLAHTRQMLAKICQIAACAPQQG
>NC_013595.1|WP_012892664.1|6803957_6806450_+|DEAD/DEAH-box-helicase
MSLVDRLPEEIDADPDAIFDAFVEWNSERGLTLYPAQEEALIEVVSGNNLILATPTGSGKSLVAAGAHFAALTRDVRTFYTAPIKALVSEKFFDLCALFGTENVGMMTGDASVNPGAPIICCTAEILANVALRDGAKADIGQVVMDEFHFYAEPDRGWAWQVPLLELPDVQFILMSATLGDVSRFEEDLTRRTGRSTAVVKNAERPVPLVYSYRMTPLHETLEEMLTTNQAPVYVVHFTQAAAMERAQALMSINMSTKTEKEAIAALIGNFRFTTRFGRALSRLVRHGIGVHHAGMLPKYRRLVERLAQAGLLKVICGTDTLGVGVNVPIRTVLFTALSKYDGNKVRRLRAREFHQIAGRAGRAGFDTIGYVVCQAPDHVVENEKALAKIGDDPKRRRGYARKKPPEGFVGWSEETFEKLQSAEPEPLNSRFKVSNAMLLAVINRPGDCYAAMKHLLTDNHEDRKWQRRHISQAIAIYRSLLAGGVVEKLAEPDDQGRMARLTVDLQEDFALNQALSTFALATLELLDMESPNYALDMVSIIESILDDPRQILSAQLNKARGEAVAQMKADGIEYEERMELLNDVTYPMPLADLLLGAYETYRRGHPWVGDYTVSPKTVVRDMYERAMTFADYIQFYELARSEGTVLRYLADAYRTLSRTIPEHLKTEDLIDLIEWLGELVRQVDSSLLDEWEQLQNPTGELEAPSLEERTRPVTANTRAFRVLVRNAMFRLIELASLEREQELAELAPDVDWGAALDAYYDDHEEIGTGPDARGPGLLRIEEEKEFWRVRQVVADPAGDGDWGIDAQVDLGASDEEGRAVVHVIGLNRL
>NC_013595.1|WP_012892663.1|6802527_6803835_+|acyltransferase
MTAVISRSAVRAAPAPQGRDVFIDVLRLFGMALVVLQHWSMPVLSFSDGRISTGNALSAGGAWVVTWISQVMPLVFFAGGAANAISWRGSVRRGGTVPAWLAVRLRRLVWPVLPLAAVWLPLPHLLQALGLPEQPVVTASRLAGQLLWFLAVYLVAVAVTPSMLRLNMLYGWRVPVVLTAGAVVVDVARFTTGLEVVGFLNIALVWLAVHQLGFLYADGRLSRPWAMALTGYGLAAALVAFGPYPGSMIGMPGAAVSNMAPPTIALLAVAFGQIGLALALRRWIVALAEWPGVSRVLAWAAPRMMTVYLWHMSALTIVTSVVVVGLGVSTPEPGTSAWLSGWPHWLLMLSLAMSPLLRCFSRFETPPQASPYAGGTARIVVAVALAGTGLLVLTVIGFVPGTAPVLGAGMLVAGLALTWSAPRLQPAARPSVESP
>NC_013595.1|WP_012892662.1|6801095_6802343_-|sensor-histidine-kinase
MRTLLRRIGTDSRYLIAGFPLSVVFFVLMVAGFAAGIGTVVVWVGLPVLATTLLVARGMADVERRMLPEVLGRALPRPRYRPAPETAGWFRRMVNPLTSGQSWLDLLYGIVAFPISVVTFVFTVTWWAGTILGLATPLYGWITAAIPGNEGLAYLLGLGDSVWIDVVINTSIGVLFALTLPVVVRSAALIRAGLGRAMLTGVAELHERIDDLAEGRAAAVSAEANALRRLERDIHDGPQQRLVSLAMDLSRAQRQLKRDPQAVEAMLSQAITSTRDTLDELRALSRGIAPPILTDRGLAPALAALASRCTIPVELDVQVTGRFAAAVENTVYFVVAESLTNVAKHSHATVCTVSLTKTGGVLMLTIGDDGVGGAHVAKGHGLSGLGDRLKAVDGELAVDSPVGGPTVIVAEVPCG
>NC_013595.1|WP_012892661.1|6800457_6801105_-|response-regulator-transcription-factor
MRVVVADDAVLIREGLIRLLEEFGCEVVAAVGDGDGLVEAVAEHRPDVSVVDVRMPPGFTDEGLRAAVEARRRVPGAPMLILSQYVEVSYADDLLADARGAVGYLLKDRVVDVDDFMGGLRTVAAGGTIFDPQVVAQLMVRRRRDDPLALLTPREREVLGLMAEGRSNPAIGRQLVISDGAVEKHIRSIFAKLGLYAEDGDQHRRVLAVLAYLRS
>NC_013595.1|WP_148269246.1|6813773_6814355_-|hypothetical-protein
MARHVLPILLGLAVLSGCGSEGTLSQAALDQARAQGVAPDLIYVVDLPGYELAEQSVGGVGGEGFGAFYVSPEGGQVELRTDRGTFSDALCADTPVKDAEPAAAVRCERDEVGWYRVAGDHHEYTVVSGDHYIRLNGRVGEADRAALKAAVAGARHVTGEGSGTPLPSRTPVERGDLPTNGDSAPDNDAGAGG
>NC_013595.1|WP_012892672.1|6814545_6815757_-|NAD(P)/FAD-dependent-oxidoreductase
MIRPGPWRSGFAGPYRGRLTWVDDVWDLVIVGGGPAGSAAALRAKQLRPAARVLLLDRADFPRDKACGDGVAAHGRDELALLGVPDLIADYRPTRRLTVVSPGGARVCATVARPNHVVPRTVFDARLVDAARARGVEVRRHRVRALAAHGGHIVVDGAFTARAVVAADGANSTVRRLIGVPASPARHTAIAVRGYADVPDDDDVQFIAMQKEGWPAYAWSFPIGDGTANVGFGMLLPRLHATGLPGREVLHGRLAELLPHLPARDLRAHHLPLSPGRPRPGAGRVMLAGDAAGLVNPLTGEGIYYALVSGRLAGEAAVQAAGDPLPAYRNALRKALGRHLRTTDVLARAAQSPGFIDAAIDTADRRQEVFDLLVDVGLGAGTVPLRLGCAVLGRWILNGVRRG
>NC_013595.1|WP_148269247.1|6816415_6817585_+|serine-hydrolase
MKSVSWRRFHAVVASAAVAASVGAPTVGPAHASSSRYDRAALQADLDAIRDAGTLGVQARVISPGGDLAAASGTAVRGRNVPIPLDGHFRMGSNTKTFVAAVILQLEAEGRLSLDDSVERWLPGLVRGNGNDGRAITIRNLLQHTSGLYDSVGDIEEKMRTERGYRTYRFLRMNPRRLVALSVGHRPLFAPGARWSYSNINYLLAGLVIERATGNSWRKEVKRRIITPLRLRNTTLPGDSPLLPKPHVQSYTEDAKTSRPFRVTLLSLGWAGAAGEAVTTTGDLSRFWRALLGGKLLPPQQLKKMTTTVPIGAPGREFGLGMAKQRLSCGVTAWSHPGGTPGFITDNAVTQDGRTSVIVSRTTYPGTREQGQATARLIDNALCGTSSTD
>NC_013595.1|WP_012892675.1|6817840_6818560_-|response-regulator-transcription-factor
MTGTGPTLPRIRVLIVDDQPLVRRGLSLILSPDPSFEVVGEAENGAQAVTLARRLRPDVVVMDIRMPVLDGVGATRELAATVPDCRVLALSTFDLDEYVVGALRAGAYGFLPKDSSPEDLSAAIRTVHAGEAAVAPRLLTRLISTYVRAPHGTRPTPTGLGELTPREVEVWRLMATGLDNTGISRTLDISLSTVKNYITSIFDKLAVRDRAQAVIVAYESGLVTARVAAGDPPGDGHTG
>NC_013595.1|WP_012892676.1|6818556_6819783_-|sensor-histidine-kinase
MPRDRHVGPGDARELPHIDSAEPPWTRNDALVTGGACVMNLLSYVFFDDPDGRYAVSVVGFLLVALAALPLLARRRHPVAALAAVLVLDATATLTVPLPSHFGAVLLVALYSVARACRSRVTAVAAVATVSLMLLSQSGGRVPPWQDAVFAPLSTLIVVGAAMAVNRWQQQVAANRRLLADRAVADERRRIARELHDIVAHHITTMQLMAGGARANIAEPEVVRDALVTLESSGRLALREMRQLLDVLRAGDEPEAAPSLPQPGADDLDRLVAESRLAGLPTEFSVRGPRRPLPPTVGLTVFRIAQEALTNARKHAGPARASVRLTYRQERITVEVWDDGGGTPPQERAPTAGSGGYGLIGMRERVALHGGTLSAGPQAGGGFAVAADLPLTMDEAAEAAVQHEGAHR
>NC_013595.1|WP_012892677.1|6820062_6822273_+|MMPL-family-transporter
MIRALTGYSTRHPWRVIALWAVLGVVLSALTPTLIAGVTQNQTGDFLPRSYDSAAALHIAQERFGVNPDATTVTVLVARSDGKALSAADRKRVEAEAAKLGKRRVIMPREDDGPQFLVPDRSQTPRIAPAMTAPDRSFELLSVELIGNRTDKGVQGVYRTFRDAARTQFSEAGMRTGFTGALADTVDTTDSHKTAATVGGALIMGLVILLNVLAFRSALAALLPLLAVAMIGFVATGAVVGGAMLTGRKLDPGITGMINVVLLGIGIDYLLFLLFRFREQLRARPEQSAREAAAQVSARVGTAITSAALTIVAAFATLGVATFGQFRSMGPAIAIAVLVTLLGSLTLLPALLAAAGRKMFWPSRTLGHEPREGRAARFGALVTRRPLTMLTGSVALLAALAAGLVGIHMDYGRGGSDARTPAAATAAEISRTLPAGVSDPTSVFVTATDGGVLTTGRLDGLSRALTQVKGVGQIARTVLNNDHRAARIDLYTTADPQSQQARDLASGPIRAAVAQHTPAGTAAYVGGTAAIFADISTAVDHDLKIVFPVAAGLIALILLLLLRSLLAPVVLMFSVGLGFAATLGAATLLFQHVLGTPGVSYTLPLVLFLFVVALGTDYNILIADRIREEMRRPGPARAAVARAVRHTTPAIATAGLVLAASFASLITSPGNEQMAFAMTLGIMLSALVVSLVLVPALAALLGRAMWWPLRPRPTKDGHRQDRATEPAPEPDRVTAC
>NC_013595.1|WP_012892678.1|6822340_6823813_-|amidohydrolase-family-protein
MTTYDLVLARGRVIDPETGLDAVRDVGVSGGVIQAVSDQPLDGVTTVDATGLVVSPGFIDLHSHSMDVAGHRLQALDGVTTVLELEAGAYPVAAAYRRAEIEGRPLNYGFATSWAVARMAVLLGLDTSGDLRDDFLANIGREEWQRAAPRNVVDRIVGMLERDLGDGALGIGILVGYAPRVDPSEYLAVAALAASVGLPTYTHARELVEMDPTTPVDGAEEIVRAAAETGAHMHYCHVNSTSIRHVDRVLGLVEKVRAEGSRVTTEAYPYGAGMTGVGAAFLAPELLHRRGLTPHSIGLLGAEGRIPDADTLRRIRESEPGSAAFVHLLDEDDPAQFDYIQRALTFTDAAVATDAVPLLWRSGASDPFSWPLGPDAVTHPRTAGTYGRTLRRLVRENGVLSLPEAVRRCTLIPADVVGSGVPAMRRKGRVQAGCDADLTVFDPETVSDRATYTETVRHSAGFVHVLVGGRFVVRDEHLLPTALPGRAVRA
>NC_013595.1|WP_012892679.1|6823809_6825063_-|MFS-transporter
MGLAEGTSTLAPAQIRKTATVTVGLLMGVWVIDYVDRVMMAVALPFIGEEFALTKTEQGWLITAFSLVYLLCQVPGGILADKFGARRQLMVSLLLWSVFTALTGIAWGLASLLVIRALFGVGQGLFPGASFKAIAERTTPAVRATAAGAMLASNQLGAGVAPLIVAPLILALGWRHTFWVTAAAGVAIGVLLWKLLPKALPAHLNGSDVVQDKGTGLGAVMRSPSVWKFAALFCTTNMLGYGLITWVPSYLLEERGISLINTGVMSAIPGLVACATVFLGGWLFDHFFHDRVRLYVIPLLLVTAVLLVLMLMADSAVGFTVYQTLAMGVAGLSSMGILGMPVRALPPAVIGSGMGVVNVGGQVAGVLAPVLMGFLVDKFSYTAAFGLLIATTVLGALIALIVPQRPEQFSLGTKELA
>NC_013595.1|WP_012892681.1|6825632_6827114_-|L-arabinose-isomerase
MKVWFLTGSQGLYGEDTLRQVAEQSQRIAAALDEALPFEVEWEPVLTDAAAIRRMCLEANSSDECVGLIAWMHTFSPAKMWIAGLDALRKPLLHLHTQADLELPWSSIDMDFMNLNQAAHGDREFGYIQARLGVPRKTVAGHVSDPSVAARIEAWARAAAGRAEVGSLRLARFGDNMRDVAVTEGDKVEAQLRFGVSVNTYGVNDLVAAVDASSDTEVATLVKEYEDLFQVAPELRAGGERHDSLRYAARIELGLRHFLEAGGFKAFTTNFEDLGGLRQLPGLAVQRLMADGYGFGGEGDWKTSVLLRTLKVMSAGLPGGTSFMEDYTYHLTPGQQLILGAHMLEVCPTIASGVPSCEIHPLGIGGREDPVRLVFDAEPGPAVVVGLADMGERFRLVANEVDVVAPVEPLPNLPVARAVWRPRPDLRTSAEAWLTAGAPHHTVLSAAVGAEELTDFADMLGVELLVIDADTTPRGFAKELRWNQAYYRLAQGF
>NC_013595.1|WP_012892682.1|6827110_6827758_-|L-ribulose-5-phosphate-4-epimerase
MRETVCALHRELVRNNLVAWTAGNVSGRVPGEDLFVIKPSGVSYDDLTPEAMVVCDLEGNLVEGAFSPSSDTAAHAYVYRHMPEVNGVVHTHSTYASAWAARGEPIPCVLTAMADEFGGEIPVGPFALIGNDDIGKGIVAVLESHRSPAVLMRNHGVFTIGDSPKAAVKAAVMCEDVARTVHLSRQLGEPLPIPQGDIDRLYDRYQNVYGQRSQR

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Crispr_ID: NC_013595_35

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_35

6935651-6935763

Orphan

Consensus_repeat	Method
GATCCGGCCGGACGGCGGCGGGACCCCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_35

>merge|NC_013595|35|6935651-6935763|CRISPRCasFinder
GATCCGGCCGGACGGCGGCGGGACCCCTCGAGATCCCGCACCGATCCGATGCCCTTACCTTGCGGATCAATAAACTGCGCGAGGGATCCGGCCGGACGGCGGCGGGACCCCTC

>NC_013595|35|33|6935651-6935763|CRISPRCasFinder
GATCCGGCCGGACGGCGGCGGGACCCCTC	GAGATCCCGCACCGATCCGATGCCCTTACCTTGCGGATCAATAAACTGCGCGAGG
GATCCGGCCGGACGGCGGCGGGACCCCTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012892786.1\|6939131_6939419_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_169369406.1\|6929504_6930764_-\|YcaO-like-family-protein	unknown	unknown	gnl\|CDD\|376866
NC_013595.1\|WP_012892780.1\|6930983_6932483_-\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
NC_013595.1\|WP_043657097.1\|6935896_6937168_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_013595.1\|WP_012892782.1\|6933009_6933771_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_013595.1\|WP_012892775.1\|6925979_6926561_+\|maleylpyruvate-isomerase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|274422
NC_013595.1\|WP_174435302.1\|6942475_6943303_-\|CoA-ester-lyase	unknown	unknown	gnl\|CDD\|225184
NC_013595.1\|WP_012892791.1\|6943328_6944489_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NC_013595.1\|WP_012892779.1\|6930769_6930910_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012892783.1\|6934299_6935496_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NC_013595.1\|WP_043657094.1\|6932479_6932809_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012892777.1\|6928311_6929505_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_013595.1\|WP_012892792.1\|6944640_6945159_-\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|239535
NC_013595.1\|WP_012892785.1\|6937544_6938768_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_013595.1\|WP_012892788.1\|6939967_6941971_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043657101.1\|6945305_6945992_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NC_013595.1\|WP_148269251.1\|6933846_6934101_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_013595.1\|WP_012892789.1\|6942042_6942471_-\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611
NC_013595.1\|WP_012892787.1\|6939522_6939981_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012892776.1\|6926694_6928098_-\|Si-specific-NAD(P)(+)-transhydrogenase	unknown	unknown	gnl\|CDD\|235373

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012892782.1\|6933009_6933771_-\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	1.1407e-48
NC_013595.1\|WP_169369406.1\|6929504_6930764_-\|YcaO-like-family-protein	gnl\|CDD\|376866	pfam02624, YcaO, YcaO cyclodehydratase, ATP-ad Mg2+-binding. YcaO is an ATP- an Mg2+-binding protein involved in the peptidic biosynthesis of azoline. There three motifs involved in the binding are, in UniProtKB:P75838, 71-79: Sx3ExxER, 184-203: Sx6Ex3Qx3ExxER, and 286-290: RxxxE. Three slightly different functional families are represented in this family, proteins involved in TOMM (thiazole/oxazole-modified microcin) biogenesis, non-TOMM proteins such as UniProtKB:P75838, and TfuA-associated non-TOMM proteins involved in trifolitoxin biosynthesis. UniProtKB:P75838 hydrolyzes ATP to AMP and pyrophosphate.	5.67458e-40
NC_013595.1\|WP_012892780.1\|6930983_6932483_-\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	3.63705e-136
NC_013595.1\|WP_043657097.1\|6935896_6937168_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.06761e-52
NC_013595.1\|WP_012892785.1\|6937544_6938768_-\|transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	5.2344e-07
NC_013595.1\|WP_012892789.1\|6942042_6942471_-\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	4.90205e-34
NC_013595.1\|WP_174435302.1\|6942475_6943303_-\|CoA-ester-lyase	gnl\|CDD\|225184	COG2301, CitE, Citrate lyase beta subunit [Carbohydrate transport and metabolism].	5.88302e-59
NC_013595.1\|WP_012892791.1\|6943328_6944489_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	3.72723e-153
NC_013595.1\|WP_012892783.1\|6934299_6935496_-\|histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	7.99725e-84
NC_013595.1\|WP_012892777.1\|6928311_6929505_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.28585e-42
NC_013595.1\|WP_012892792.1\|6944640_6945159_-\|MaoC-family-dehydratase	gnl\|CDD\|239535	cd03451, FkbR2, FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The function of FkbR2 is unknown.	1.66795e-74
NC_013595.1\|WP_043657101.1\|6945305_6945992_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	9.84396e-43
NC_013595.1\|WP_148269251.1\|6933846_6934101_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.21878e-07
NC_013595.1\|WP_012892775.1\|6925979_6926561_+\|maleylpyruvate-isomerase-N-terminal-domain-containing-protein	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	0.000861219
NC_013595.1\|WP_012892776.1\|6926694_6928098_-\|Si-specific-NAD(P)(+)-transhydrogenase	gnl\|CDD\|235373	PRK05249, PRK05249, Si-specific NAD(P)(+) transhydrogenase.	0

>NC_013595.1|WP_012892783.1|6934299_6935496_-|histidine-kinase
MEPVVAVLLIATLVGVPALVLWRVLRGRRELGSSPAERATFETLHTASLAAPPLRAGLTEAGAQKASRYLRELLGSPALAITDGERLLVYDGEGDHHAREAFTHAAKTLAGGRTQVLGPEVVSCEIPECPIRFAVVVPLTTDGRVVGSLAAYGGHASAGLVRATHEVANWVDSQLELAELDRSRTRLMEAEVRALRAQISPHFIYNSLTTIASFVRSDPDRSRELLLDFADFTRYSFRRHGEFTTLAEELRSIDRYLTLERARFGDQLQVTLRIAPEVLPVAVPFLCLQPLVENAVRHGLESKPGVGRISIIAEDAGAECLISVEDDGVGMEPDRLRRILAGDADERSGAGGVGLANVDERLRQVYGDEYGLVAETGKGAGTKVSVRLPKYHPGVSAR
>NC_013595.1|WP_148269251.1|6933846_6934101_-|MFS-transporter
MSVRQALVPPHLFGRVLGAIRTLLWGLIPLGALAGGLLAGAFGLRAVFMISGCVMLALMVPLCWVLWRHRELINTLREPGTVDT
>NC_013595.1|WP_012892782.1|6933009_6933771_-|response-regulator-transcription-factor
MTGLRVLAVDDELPALEDLAYLLRDDPRIGEVSLARDGAAALRVLDRAIADGRPIDAVFLDIRMRGLDGVVLGRLLSQFANPPRVVFVTAYEEHAVDAFEIKAEDYLLKPVRPERLAEAIRRVCVSAELPDSDGAGRTDPGTIPVELGGVTRFVASTEVRYVEAQGDYARLHTAGGSHLVRISLATLEERWSSAGFVRVHRSHLVAVKHIDELHIDSGRCVVRIGETEIPVSRRHTRELRDLLVRRARKGRPE
>NC_013595.1|WP_043657094.1|6932479_6932809_-|hypothetical-protein
MAARHPRYPVTREIDEQTRLGEVYMGSLIRTQFRLALFVCTVLGCVVGGLPMLFLLVPELREVRLLGIPLPWVVLAGLIYPAFVIGAWLYVRQAERNERHFAELVDRAR
>NC_013595.1|WP_012892780.1|6930983_6932483_-|cation-acetate-symporter
MNTAYGVTAVVLVVLAAVLIGAFGIRLSRTTSDFYVASRTVSPLWNASAIGGEYLSAASFLGIAGLILAYGADMLWLPVGWTGGYLVLLVLVSAPLRRSGAYTLPDFAEARLESMAVRRMAGVLVVLIGWLYLMPQFQSAGLVLAAITGAPEWAGGLLVAAVVAVNVMSGGMRSITFVQAFQYWLKLTALAVPLVFLLLAWRAGGAPGLSAEDAATWALPLSSGKEYGLYSTYSLILATFLGTMGLPHVLVRFYTNPEGRAARRTTLVVLSLLGAFYLLPAIYGALGRIYVPELRGSDMVVLTLPGRLVGGVAGDLLTALVTAGAFAAFLSTSSGLTVSVAGVIGQDILRGGVRSFRVAALLAVVAPLALATSARSLPVADVVGLAFAVAASSFCPLLVLGIWWRRLTSTGAMAGLIVGGGLACGAVLTTIAGGPYTGLAGALLAQPAAWTVPVAFAVMVVVSLLTPGRIPAGVARTMVRLHTPETLNLDRGDWRPRSS
>NC_013595.1|WP_012892779.1|6930769_6930910_-|hypothetical-protein
MGNSNSNGQSLLKPDGFQLEDSFSFTLAETVLLDQFFAARSAPGAL
>NC_013595.1|WP_169369406.1|6929504_6930764_-|YcaO-like-family-protein
MARAQRERCTGLAEALSLIESVLADSGLSAEFLSTGSAEFPVHRCTLRDPAGRVLTASLGKGAGAQSTVSALFEAWQHLQHEEGQAALPGDHRRARAVPVATVVAQPELCGEQMIHRLARDYPDIDLACLRAEPLNPERAALWYPAFTRSPSCRSHPIPGDDLRYEPYLRYAYDNGTATGATEPEALLHGLLEVIERDALSHALLDWYLDERPRLSALGPDLLPPDLRRLHDEATARLGAPPLVIDITSDLGIPTYCALPSRAGPYPGVVGSGASLDPEYAVERALTEVIQSSFNLSLGVDLTLGRRLESLRRWPLLERCARLDPAPLLDRLTFDARLPGRRPEDAGEAPGDVGEQIATILETLERAGLPAYSFRWNPAHDRCPVLTVIVPGLETFAMVHSAVPVFPTGRAVRRLAGHR
>NC_013595.1|WP_012892777.1|6928311_6929505_-|MFS-transporter
MRAVLRERGFRLIYLGMAVSLLGDASLLLIPAILAKKLTGSDGAAGLTLFFFTLPLCLSPLFGYVIDRVDRRRFLIAACLLSAAALTPLTAVTGGDTLWLLYPVSAAMGCSYAAISGALSGLLKSVLPEDLLAEANGALQTTRQGLRLVGPLLGVAVYTSSGIGAVVLLDAGTFVIAAAAFAALPKPAPVPAAPRGRWREEFSAGARHLAADPFLRRAAGAFCLMFALAGATESLIFAVIDHGLGRAPEFTALTSTAMGVGAIIGGLCGATVIRCRGELFAIGTGIALYGVAVLLWTVPAEPAVLGAMTMAGAGLTLAGVARMTLVQRRSPGHLVGRVSTAFEAMAGATQLLSLVAGAALVSLVDYRLLLAVVGLTICCAAAHALRGRTPAEHPRPG
>NC_013595.1|WP_012892776.1|6926694_6928098_-|Si-specific-NAD(P)(+)-transhydrogenase
MWDFDVLVLGSGPGGQKAAIAAAKLGKRVAVVEKKHMLGGVCINTGTIPSKTLREAVLYLTGLNQRELYGASYRVKDEITVADLGMRTQHVIGREIQVIRSQLGRNHVTVLQGTGRFLDAHTIGVTGDEERKVTAEKVVIATGTSPARPSSVEFDDKMVIDSDAILHLDRVPETLVVVGAGVIGIEYASMFAALGTKVTVVERRERMLEFCDLEIVEALKYHLRDLAVTFRFGESVAAVERRPRGALTVLESGKKIPADCVMYSAGRQGKTAELCLAAAGLAADDRGRIEVDENYATPVPHIYAVGDVIGFPALAATSMEQGRLAAQHACGEPVTEMHELSPIGIYTIPEISFVGKTEDELTRDKIPFEVGISRYRELARGQIIGDSYGMLKLLVSSEDRRLLGVHVFGTGATELVHIGQTVMGCGGTVDYLVNAVFNYPTLAESYKVAALDAMNKMRVIARLTAEL
>NC_013595.1|WP_012892775.1|6925979_6926561_+|maleylpyruvate-isomerase-N-terminal-domain-containing-protein
MTISWPDLVTSAAADGVSVLAKGADQDWSRDAGDLDWTCRQTLDHMALGVVGYAGLLIAQPADRYIALFASLDGQAPIPACLEGIRISATILASAVREAVPEVRAWHPYGHSDGPGFAAMGTLEILVHSRDIALTLGIDWTPPDDLCAPVVERLFPDAPAGHDPARTLLWCTGRVALPGLGRRKEWQWHGDVR
>NC_013595.1|WP_043657097.1|6935896_6937168_+|MFS-transporter
MSAPTTSPPGACAPSVRRDFGLLWAGQSLSLFGDQFMTLALPLLAVTVLEASPAQAALLPFALFLPFLPLGLPAGAIVDRLSRRMTMLVCDGVQVAAFGAVWALAATGTLTFPLLFCLVLLSGCAMVFFQVAYTSYLPSLYGDPQDLHRGNTRLALSESASKALGPMAAGPLIHVLGLVGALAANAISFTASVVSLALIRHREQPGESAPRVRGWLRRDVATGLRFALGHPILQPVLMCGTTYVLFLSMVETSLVLYCRNVLGLSPQWIGVVIGAAAAGYPIGNLLSSRLIRRFGTPRTLLGAASLSVLGIVSMPALGSLGGAAGTAGLIAGSIVHCVGEGAFSPTSLTLRQTATPAGLLGRVGAVQRFLLWGAVALGSLLAAGATALGGLSAAVWIGALGTVLCIPALLRQGIRAAVLPQTS
>NC_013595.1|WP_012892785.1|6937544_6938768_-|transcriptional-regulator
MAYSDPAGESAGTHVRRARKRAGITQRELAQRVGRAQSWVSGVENDSIPLDSIALVNGLARVLRIHPNELTARPYRGDTPAEDRGHSAIPEIRRHLERYDLDPEWGGEVRSLPELRAGTERASWLRLEARYAELAEELPALLSELQAATHLSPEPDRSAAFSLLSLAYQAAHSVACNLGYADLSLIAADRARWAAECSGDPYHEAVFACIRVRNLWSSTSWNDALTVLDSACAHIEDRYIAGQPKALAVWGGLQLRAAITAARKNDAAEAWSRHRLAAEAVARLGPRQRTNYYDLSTNQPNIDIHGVAIAVELGDGPQAVRRGETVRLPKGLQAGRVGHHHLDHARGLLWCGKREAALAELECAEKIAPLLIRNHPMAQQAVRTLLDLERYSYRERIRRLGVRMHIL
>NC_013595.1|WP_012892786.1|6939131_6939419_-|hypothetical-protein
MGFGPEGIANPRREELLRALTRVQLHAVQLETALDPAHASLTGKAVWAGPTARAFAEELTGRRNRLRTLVQRIVEDLEAELRATPEKVDRSSNVR
>NC_013595.1|WP_012892787.1|6939522_6939981_+|hypothetical-protein
MPRSAPSFPVRLGVTLLATALTLAACGEREPTAVEAGATLKAHILKLLKEVNTQNIQITDPGGKDIPCGDGKFKRTFAAIGHGAPPYSQPIYMKDEMRGALGRVANYTSIGVPDLSKPATIADKSARTVLVLDASSMGRYLVSGETECLNQS
>NC_013595.1|WP_012892788.1|6939967_6941971_-|hypothetical-protein
MGETPAVMPGTGPLGPEFNGIDPVLMNGFIAELERAGKAIAEHGEAIRRELAAVDLPTPGIASIREIGGWAEEQLPRLRQRVETIEVMPAILLGSKLEPYSEGALPAPVEVRRQGAELGKRVAAVDPEAFSLTGPYPTERLAALVNELKAHQSDPNFTAAFFAALGPAGTRKLGEKLRRLEKADDALGIAGTALGTAARGGARIPGFAQVMGAVKKAEVKDIEGFAELLNSGDYPDVWLAEIVAPMLAADSHVSGETLGKLLNALGNNPVAARLAISSVTDISPVPASAKTPFGILPSSPQVWKARPDLAAFLKTLNERVNWQPAAAKGFGRMLAAASGAYDEAQGKHSQEAAFFAYTVMTSVDDLKLGDATRPHLSEIAGSYAAEITLGANIGDADMTKDSALQLTPGPFEPTMVPGLRGAFRLSPEDTFRFLTTFAGTAEARAPFEAGMGELTQRLLPEASRLAKSTKDVTTLDNLFTALGNVRGFELAAAVRVLKPSDEEAESAKDAEDLLVGALMGVAGLVPPFSIYAKTWAGICTGKAAYDTYGPQAEEKVEKLRELDGMETLGRQYAVAQLLVKQGFTPRTPPSGTVIADSNGKLRPFGEIAKQGDVGMKALEQWFIENGMGAENRMLPGGLSRLLADRFDGRKNFGYERAHLYKKGLTTD
>NC_013595.1|WP_012892789.1|6942042_6942471_-|HIT-family-protein
MPAGECSFCAIGAGEQPGHVVLSDEVAVAFLDTRPVFKGHVLVAPRAHVETLPDLPPPEVGPFFERVRSVTAAVEQGLEAGGTFVAMNNRISQSVPHLHVHVVPRNRKDGLRGFFWPRTTYDDPAEAEAYALRIRKALDPNP
>NC_013595.1|WP_174435302.1|6942475_6943303_-|CoA-ester-lyase
MRSALYVPGDQPGKLAKALDRGSDSLIVDLEDAVLPAHKAEARAAVAGWLRGLGPGGPEIYVRVNPGEAGHEDLRAVALPGVRGVCVAKTESAAELEAVDAVLAAAEAAEGLPGGSIAVCPLLESAGAVLSAPEIARAPRVLRLQIGEADLRAELGVETGSDERELLWARSQVVLASAAARLTPPLAPVSTDFRDLDALRASTVALRRLGFRGRACIHPAQLAVVNEVFTPTEEELAQARDLIARFEAAGTGVVTDARGRMVDEAIVRAARRLLS
>NC_013595.1|WP_012892791.1|6943328_6944489_-|acyl-CoA-dehydrogenase-family-protein
MDFELNDEQRLFRRTLREFVDKEIVPVASEWERTGRYPTEIVERFKQMGLFGMTIPEQYGGLALDRVSFALVFEEIARGWMGVAGVLGSHSLASWMIAEHGTDEQRDAYLPDLATGARRTGIALTEPAAGTDLQGIQTRAVRDGDHYVINGTKTWITNARHADPMPVLVKTSVTEPAHRGMSLILVEAGTPGYTVSRDLPKLGYKGTETCEIVLEDVRVPASRLLGGVEGRGMQQALSALELGRVNIAARAVGISQCAYDAALNYSRERHAFGHPIADFQAIQLKLADMATDIQAARLLTYWAATRSESGAVNSEAAMAKYFASEVALRVTMEAMRIHGGYGYSQEFVIERLYRDAPLMAIGEGTNDVQRMVIARSLISGTAKVGW
>NC_013595.1|WP_012892792.1|6944640_6945159_-|MaoC-family-dehydratase
MTVHEPGLGRYYEDFVVGDVYQHPLGRTISEADNTWFTLLTMNTNQNHFNAHFAGRAPVGKIIVNSGLTVAIVLGISVIDVSQTALMNLGWDEIKLTHPVFLGDTLYAESIVVAKRESGSRPYAGIVTCRTRGLNQDGDEVMSWRRSVMVYRRDAPHDKHYFPQAKTGPLTT
>NC_013595.1|WP_043657101.1|6945305_6945992_-|FadR-family-transcriptional-regulator
MDVTAYQALAADLRDRIVSGEFQPGDRLPIEPDLCVRYGVSRSTVREALRLLASQNLIRTVRGVTGGSFVAHPDPDHISAYLETSFDLMRVGIGQLMEIRELLEVPAAGLAALRRTGADLERLRGCIVGASGREPGEVFAPNRDFHIVLFRAAGNPLLEVVARPVFEVLEGRFVRDRAPRAALDGIDREHRDILRHIEAGDAEGARRATLEHLDNLRTAYYPSVEPRE

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Crispr_ID: NC_013595_36

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_36

7296629-7296802

Orphan

Consensus_repeat	Method
CGCGGGACTGACCACGGGCGCCGGGCCG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_013595_36

>merge|NC_013595|36|7296629-7296802|CRISPRCasFinder
CGCGGGACTGACCACGGGCGCCGGGCCGCCGGAAGGCCCCCTCGGACGACCGCTTCCGCGGGACTGACCACGGGCGCCGGGCCGGTGGCACGGGTTTCGGGCGCAGGACTGACCACGGGCGCCGGGCCGGTGGCACGGGTTTCGGGCGCGGGACTGACCACGGGATTCGGGCCG

>NC_013595|36|34|7296629-7296802|CRISPRCasFinder
CGCGGGACTGACCACGGGCGCCGGGCCG	CCGGAAGGCCCCCTCGGACGACCGCTTC
CGCGGGACTGACCACGGGCGCCGGGCCG	GTGGCACGGGTTTCGGG
CGCAGGACTGACCACGGGCGCCGGGCCG	GTGGCACGGGTTTCGGG
CGCGGGACTGACCACGGGATTCGGGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012893071.1\|7291876_7293220_+\|MmgE/PrpD-family-protein	unknown	unknown	gnl\|CDD\|377179
NC_013595.1\|WP_012893073.1\|7294284_7294761_+\|MaoC-family-dehydratase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379194
NC_013595.1\|WP_012893081.1\|7300380_7301793_+\|dihydroorotase-family-protein	unknown	unknown	gnl\|CDD\|236240
NC_013595.1\|WP_012893078.1\|7298264_7299062_-\|cyclase-family-protein	unknown	unknown	gnl\|CDD\|224790
NC_013595.1\|WP_012893067.1\|7287774_7288971_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NC_013595.1\|WP_012893084.1\|7303711_7304407_-\|DsbA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|239322
NC_013595.1\|WP_012893080.1\|7299503_7300355_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NC_013595.1\|WP_012893077.1\|7296861_7298268_-\|MmgE/PrpD-family-protein	unknown	unknown	gnl\|CDD\|377179
NC_013595.1\|WP_012893066.1\|7287154_7287778_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_013595.1\|WP_012893082.1\|7302003_7302909_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|372282
NC_013595.1\|WP_012893069.1\|7289667_7290669_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|132656
NC_013595.1\|WP_012893075.1\|7295134_7296280_+\|thiolase	unknown	unknown	gnl\|CDD\|180434
NC_013595.1\|WP_169369423.1\|7302887_7303520_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|225360
NC_013595.1\|WP_012893087.1\|7306522_7306945_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893085.1\|7304952_7305726_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|274042
NC_013595.1\|WP_012893070.1\|7290665_7291880_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NC_013595.1\|WP_012893086.1\|7305725_7306169_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893068.1\|7289023_7289671_+\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|238497
NC_013595.1\|WP_012893072.1\|7293250_7294288_+\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100004
NC_013595.1\|WP_148269738.1\|7294811_7295138_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239539

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012893071.1\|7291876_7293220_+\|MmgE/PrpD-family-protein	gnl\|CDD\|377179	pfam03972, MmgE_PrpD, MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle.	6.26686e-107
NC_013595.1\|WP_012893073.1\|7294284_7294761_+\|MaoC-family-dehydratase-N-terminal-domain-containing-protein	gnl\|CDD\|379194	pfam13452, MaoC_dehydrat_N, N-terminal half of MaoC dehydratase. It is clear from the structures of bacterial members of MaoC dehydratase, pfam01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerize to form a whole. Divergence of the N- and C- monomers in higher eukaryotes has led to two distinct domains, this one and MaoC_dehydratas. However, in order to function as an enzyme both are required together.	9.19182e-25
NC_013595.1\|WP_012893081.1\|7300380_7301793_+\|dihydroorotase-family-protein	gnl\|CDD\|236240	PRK08323, PRK08323, phenylhydantoinase; Validated.	1.76661e-94
NC_013595.1\|WP_012893078.1\|7298264_7299062_-\|cyclase-family-protein	gnl\|CDD\|224790	COG1878, COG1878, Kynurenine formamidase [Amino acid transport and metabolism].	3.13861e-29
NC_013595.1\|WP_012893067.1\|7287774_7288971_+\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	3.51366e-154
NC_013595.1\|WP_012893084.1\|7303711_7304407_-\|DsbA-family-oxidoreductase	gnl\|CDD\|239322	cd03024, DsbA_FrnE, DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins.	4.49025e-73
NC_013595.1\|WP_012893080.1\|7299503_7300355_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	3.20243e-68
NC_013595.1\|WP_012893077.1\|7296861_7298268_-\|MmgE/PrpD-family-protein	gnl\|CDD\|377179	pfam03972, MmgE_PrpD, MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle.	1.45868e-113
NC_013595.1\|WP_012893066.1\|7287154_7287778_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.41052e-40
NC_013595.1\|WP_012893082.1\|7302003_7302909_+\|alpha/beta-hydrolase	gnl\|CDD\|372282	pfam12740, Chlorophyllase2, Chlorophyllase enzyme. This family consists of several chlorophyllase and chlorophyllase-2 (EC:3.1.1.14) enzymes. Chlorophyllase (Chlase) is the first enzyme involved in chlorophyll (Chl) degradation and catalyzes the hydrolysis of an ester bond to yield chlorophyllide and phytol. The family includes both plant and Amphioxus members.	3.05797e-06
NC_013595.1\|WP_012893069.1\|7289667_7290669_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|132656	TIGR03617, F420_MSMEG_2256, probable F420-dependent oxidoreductase, MSMEG_2256 family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by MSMEG_2256 from Mycobacterium smegmatis. [Unknown function, Enzymes of unknown specificity].	4.19084e-56
NC_013595.1\|WP_012893075.1\|7295134_7296280_+\|thiolase	gnl\|CDD\|180434	PRK06158, PRK06158, thiolase; Provisional.	2.74984e-162
NC_013595.1\|WP_169369423.1\|7302887_7303520_-\|PAS-domain-S-box-protein	gnl\|CDD\|225360	COG2771, CsgD, DNA-binding HTH domain-containing proteins [Transcription].	8.56491e-13
NC_013595.1\|WP_012893085.1\|7304952_7305726_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|274042	TIGR02224, Tyrosine_recombinase_XerC, tyrosine recombinase XerC. The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerC, one of two closely related chromosomal proteins along with XerD (TIGR02225). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and homologs of XerC on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerC, as some apparent XerC examples score in the gray zone between trusted (450) and noise (410) cutoffs, along with some XerD examples. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair].	6.15601e-29
NC_013595.1\|WP_012893070.1\|7290665_7291880_+\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	5.08596e-144
NC_013595.1\|WP_012893068.1\|7289023_7289671_+\|isochorismatase-family-protein	gnl\|CDD\|238497	cd01015, CSHase, N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.	2.1571e-67
NC_013595.1\|WP_012893072.1\|7293250_7294288_+\|RidA-family-protein	gnl\|CDD\|100004	cd00448, YjgF_YER057c_UK114_family, YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	1.04733e-13
NC_013595.1\|WP_148269738.1\|7294811_7295138_+\|hypothetical-protein	gnl\|CDD\|239539	cd03455, SAV4209, SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and gamma-proteobacterial members of this CD have, in addition to a hot dog fold, an N-terminal extension.	5.20593e-20

>NC_013595.1|WP_012893075.1|7295134_7296280_+|thiolase
MTGVAIVGAAESDLGITGESVLTLQAQAVTRALADAGLPLSDVDGLATCGVSRFSATQVADYLGLRPVWTESTFAGGCAFEMYVARAVQAIEAGQCRTVVISYGSNQRSARSRSLAGVVEEHTPEARFEAPYGPLYPFSYYAMAAQRYMHAFGVKREALAEVAVAARDWALLNPKAYRYGAAPLTVRDVLSAPMVSSPLTVADACLVTDGGGAVVLTSLERARDLRRAPVRVLGYGECVTNTSMTAVDDLTVTGAVRSGAAAFTRAGLVPGDVDVAQIYDSFTITVLLTLEGLGFCGAGEAGDFVAGGRTGPGGAFPVNTSGGGLSYNHPGQYGLLLLVEAVRQLRGECGDRQVPGAEVALAHGTGGILSAHATVLLGVDR
>NC_013595.1|WP_148269738.1|7294811_7295138_+|hypothetical-protein
MIAYAGATWDWHRLHHDAAYLRARGLDRPVVDGQLFGALLAEQVQDWLGPDARLRRLRFRLLSMVFAGESVRVTGVVTGVEGTLVTVEQKVLVAGRVAVGGTAQAVLP
>NC_013595.1|WP_012893073.1|7294284_7294761_+|MaoC-family-dehydratase-N-terminal-domain-containing-protein
MNLPIEEIRALVGREVAYTAPEPLGRAALRYFALAVGDDNPLYTDAGHARAHGYRDVVAPPTLICETNQYAGLPMDADGYAGHSWHIDVPGARLVRGGNDYTFHQPVHPDDVITATWRIEDVEEKAGKLFVTSRATYTNQRGELLAVNEETLIYVEIP
>NC_013595.1|WP_012893072.1|7293250_7294288_+|RidA-family-protein
MTVYLPAVPGYEEAAALLDTAGLAVGDLVHVVEYVTAGALDGYASVSAAREGFLGGHAVPVATVAVAGLLGPGPYAVELTAFPGGGDLVVAHPDTGFHRGSLRVAGGVVYLPGIQPCDAEGLVHAGDFRAQYGYCLDRAAELLKAAGLGPGALVRTIDYTATATRAEYPRCGRPRRELLGGTGADGLPVFPGAAGILVDRPVLAGAMVSLDALASTAPSRTVNPGWSRYETLTYRPGVAAGDTLFMSGFGALEPATQEVVFAGDLAAQAGFVYAGIAAVLREAGLRGADVVRLVEYVTPEGVAAHPDLAALRARHFGRAPVSAVVCSALLRPEFLIEVVPVAVRP
>NC_013595.1|WP_012893071.1|7291876_7293220_+|MmgE/PrpD-family-protein
MTVAAELARWALDLRGIPGDAASAVRRHLLDGLGAAVAAARSGAARLAVDVASALGGPPEATIIGGAGRVGAPAAALANGTLVHALDFDDTHAGGLVHATAPVLPAVLAVGEEVGASGAEVAVALAAGLETICRLGAAVPHGFHARGLHATSVCGVFAAALAAARLYRLSPEQAVNALGVAGSQAGGLLESVNTGASTKQLHPGLAALGGVLAARLAAAGATGPASVFEGRYGLYNVLAGRQVGGAAVLAGLGERWELTRITIKPYPVCQLSHAALDAAGRLRPRLGGRDVDEIVVEIHPDAAQFVCGPGKERPASAYAAKFSLPWCLAALLVDGTLTTATFDDLDRPEVVALAARVRHELADSGGVAAGQPGRVIALLADGSRVEAAVERSGGGPGDPALDELVRTKAAANLGGTAVVATVDVLERLPDLTSLMAALRGPLTSSPP
>NC_013595.1|WP_012893070.1|7290665_7291880_+|CoA-transferase
MRPLEDVRIISLEQYGAGPFGSLHLADLGAEVIKIEEPRSGGDVGRYVPPYADGGDSLFFEAFNRNKRSLSLDIATPGGREVFEDLVRGADAVYSNLRGDVPQRMGITYGALKHLNPRIVCCSLTGFGMTGPRAAEPGYDYILQGLAGWMDVTGEPEGPPTKSGLSMVDYSGGFVAALALMAGLHAARRDGVGTDCDVSLYDTAVSLLTYPGVWHLNAGYAPARTRHSAHPSLVPFQVFETADGWIVVGCAKEKFWRRLAAAVGRPEWAEPDSPYGTFARRTERAGELLPLLEEIFRSRTAARWLALLTPAGVPCGPVNTVEQALAEPHTAARDLVVETDHPRYGTLRNLASPVRVGGERPSYRRAPRRDEDAGYVLREVLSYDASRIAALRRDGAFGPQEPAR
>NC_013595.1|WP_012893069.1|7289667_7290669_+|LLM-class-flavin-dependent-oxidoreductase
MRITYGPWGETLGELAAAARAAEDAGAEVVWVPELHRSATVGAAALAGATTRAQVGTAVALAFTRSPMTLALEALDLDELSGGRFVLGLGSGVRRLNEDWHGVRWDRPVARLRETVAAIREFVARCGTGEPIDAPGLRIRGYRRPFPAARDRIPVYLAAVGPAMTRLAAGIGDGWISHELCSPAYLRDRLLPRIGEGLAGRARSDLDVVVSACCSIDEDPRAARRRAAGGVGFYASVRAYSGLFDFHGLAGEQARVVEAFRSGSGAGDLAGAVPDHMVGALTLSGTARQVRERLGAYEGLADTVKLTPPTHGIPAEETRHAQDRIIELIGDLT
>NC_013595.1|WP_012893068.1|7289023_7289671_+|isochorismatase-family-protein
MIRDHDEVFGGSLPFGERPALILIDLMRAYFEPGGELFLGSRDCLESAARVLAAARTAGVPVIHTRVAFGPGGVDGGLFFRKVAPLRHLVGDGPLGRLMPEVAPGPEEVVIVKQYASAFFGTTLASTLNALRADTLVITGVSTSGCVRASAVDAVQHGFVPVVVRQAVGDRDPRPHEAALFDIQAKYGEVWDEAAVTDRLGGGRRLRAGNGPPAA
>NC_013595.1|WP_012893067.1|7287774_7288971_+|CoA-transferase
MRGLPLDDVRVVELGQLLAGPFCGQLLGDFGAEVIKVEDPGRGDPMRQWGREKPYGQSLWWPVVARNKKSVTCDLRTREGQDLVRRLVERADVLLENFRPGTLERWGMSPERLHELNPRLVITRVTGFGQTGPYAPRAGYGSIGEAMGGIRHVTGDPDRPPSRTGISLGDSLAATHACVGTLVALHERERSGRGQVVDSAIYEAVLAMMESMLPEWQQAAYQRERSGPVLPNVSPSNVYPTGDGDSILIAANQDSVFSRLAAVMGRPELAADGRYATHGARGGNAAELDELIAAWTASAPAEDLLKALHEGGVPAGRVYTAKDMFEDPHFAAREAIVRVPHPDFGELAMQNVVPKLSATPGAVRTAGPALGRHNDEVYRGLLGLTDEEIAALSAAGII
>NC_013595.1|WP_012893066.1|7287154_7287778_+|GntR-family-transcriptional-regulator
MSTVDDLRGLILAGRYASGDRLGEVELAEMLGVSRTPVRDALRQLQSEGLVEITANKGAKVMEYPRADLETIFELRAGIEGLAARRAAATATEQDAGRLHEVAVTLGEHARRHDLDAVYRLNAEFHQALVRLGGSAVLAQSISSLVHSPVLLRTYSAFDEEAMRRSVNHHIEIAAAVRAGDPDWAEAVMRAHLFSARASLLGPRERP
>NC_013595.1|WP_012893077.1|7296861_7298268_-|MmgE/PrpD-family-protein
MTTFAGHLARFATGCRDGGLPAEVARDAVGRVRDVLGNCLAAHAEEAGEGPGGPVAAVRRVVAAWGGTAGAAAIGLPYGLPAPSAALVNGTLAHALDFDDTHLPSVLHPSASVVPAALAAAEDAGAGGAALLAAVAAGDEVCVRLGTASYLPELRNSLFFEKGLHATSICGTIGAAVAAGLLYGLDEEGIASAIGVAASMGAGLLEANRTGGTVKRVHCGWAAHAGVTAAMLVREGLTGPPTVLEGRFGFFAAYLDGRHDADALLAGLGERWEVTRTVYKPYPANHFTHPAIDCALALRARGLDPDDIEEIELGAPAPVLRTIAEPHEEKISPRSPYHAKFSGPYTVATALLGGGGLGVYLDDFAELHPRRLALAARVRCVADDRASELFPVSFGAVLRVRVRGGATLTHRVDSSRGGPDNPLSPGELALKFRLNAARALPAPAVAALDRRIAALATASSCAGLARLG
>NC_013595.1|WP_012893078.1|7298264_7299062_-|cyclase-family-protein
MREPWEAVAGARVFDLAQPMSTGMPQSPNHPPFRMLLERRHGDVVRADGGSAANEIIVTGGHVGTHVDALAHVSHAGLLHGGREAAALQSHRGLSALGIDAFVPYVGRGVLLDVAAVHGVATLPAGYEVTPEDLDRAAAGLDIGPGEAVLVGTGWSRRWPEPEVFTGQSHGAPGPGVAAGRWLADLNPRLVGAETIAFEHVAPGRGHATLPVHRLLLVEEGINIVETMRLDELLDSGVREFLLVVNPLPVVGASGSPVRPLAVAR
>NC_013595.1|WP_012893080.1|7299503_7300355_+|IclR-family-transcriptional-regulator
MPIDISEPPRRGVDTSEQPRRRGSEGASQTAATVERAADVLVLFADPGALTLGVTEIADRLGLSKAAVHRILASLRLRGLVELDEETRRYSLGLTTMRLGLAYLDRLDIRRLAAPELAHLSRTLSETATLSVRTGSSRVYVDQVTPSREVIMSVTLGVPYPLHAGASSKAFLAFLADEEVDAYFRTVPLTPLTERTPVREDVLREDLAAIRRRGYARSNAERQPGSASVAAPVLDHHGRPAGVISVCGPLERFRDEAPKCAEALLEATDRLSARMGHTSRGRG
>NC_013595.1|WP_012893081.1|7300380_7301793_+|dihydroorotase-family-protein
MTRYDLLVKNGTLVLPYHGEIRADLAVSGGRIVVVGEDLDGAEEVIDATGKVVLPGAVDAHFHIGIYRDMALDAFEETRSSLVGGATTVLSYFRTGRHYLDRTGPYGTIFPEVLAAVGGRAWTDYGFHLAPMTIEQIEEIPRLVAEHGITSYKYYMFYKGFDLAANSRDAQAFTMGDEYDLGHLFLIMEKLAEVQRSRPDRRLSLSLHCEQSELMRVFIDRVRRSGAVQNLRAYSEGRPPLTEQVAIAEAAAIAAHTGADVNFLHLSSAEALEAASRTPGRRETTLHHLCLDHDDLDARGELGGKVNPPIRTRAHNEALWEGVRDGRIDWVASDHACCMEEHKGDDLWPAHPGFGGTALLYPVLFSEGHLRRGLPLSRIAEVASANPARAYNLWGRKGSLAVGFDADLTVVDPSATRTVTADLLLSGQDHCPFEGVEVTGWPTTTVVGGRIAFHDGEAVGRPSGSYLHRG
>NC_013595.1|WP_012893082.1|7302003_7302909_+|alpha/beta-hydrolase
MRSWSIRICAILLIPLLFLTAAPAGASVDLSAPGSYAVGYADVSVSASGRSFSARVYYPATSAGSGTPVASGQFPAVAFGHGFFQTISKYATLGGHWASWGTITIMPTSQGGLFPNHSAFADDLNAALTWMVAQNTTAGSRFNAHVRTNRLGLSGHSMGGGAGVLAAARNSSVRTVTNLAAAETNPSAAAAAATTTVPMQLVAGTNDSVAGPSGHQIPIYNAKLAPKQLRTIIGGFHCGFTDSGGIGCDSGSITRAAQQAITRRVTTAWLLYYLHDDTAQHDAVWGTSAQTDPAVQFLGVQ
>NC_013595.1|WP_169369423.1|7302887_7303520_-|PAS-domain-S-box-protein
MKGRYQVYFERARIPIAAVDGLGRVRESNPAFRSAVARTAEELDGVLAEELLAPGEIDAQRPYWRMLAFGRLDVYRTRIRLVRGDGAVICARVSASVEHRADGLPWRAVAVLDEISSAAPVLSPLQGEVLRLVAGGASNAQIARRLYLTRQAVDYHLVRLRAKLGAESRSALAGRAFVLGLFVPGVWPPVLHPPLAGAGAPECGYWTPRN
>NC_013595.1|WP_012893084.1|7303711_7304407_-|DsbA-family-oxidoreductase
MKVEIYSDVVCPWCYIGHTRFARAVERYRAKGGEVEVELRPFQLAPDAESNGEPTLTWAAAKFGGAERAAQMFGHVTGVAAEDGLALDFDHSIQANTFDAHRLIRLAGEQGKGEEALYALFRAHFTDGLDVGSREVLAKLAAELGVRADLGGEDGAAAVREELAQARALGVSSVPLFLFEGQFAVSGAQPEDTLLAALEEVAERTGQAVKAVKTAGADGDACDEDEGYCAV
>NC_013595.1|WP_012893085.1|7304952_7305726_+|tyrosine-type-recombinase/integrase
MTEDHLTHYRDGIGTGSARAGLGRPGVAPAPATVARRLSSLYGYATRRRLIAVNPADSVERPKVSTVGTTPARTVEEATALVDGAETISAAYPADAAAVALLSVCAVRVGELVALTVGSVAADAGHMVILFRRKGGKTDRMPIPPRVRALLEPLLADRSPGEPLFVREADRPFDRWRMTTALRRAATAPGVDHTKLTPHTARATAATAALDAGVPLADVQELLGHASPVTTQRYNRGRRKLDSHAAYRMASILGGGA
>NC_013595.1|WP_012893086.1|7305725_7306169_+|hypothetical-protein
MTESGSTPSLHEALATIAAAARAAYSGGSHLRVRSSGIVHEVATTRWFADERMPGPACMVGVSGWDPAAAHPDRGAGTCRRCLKLTHTEPADEQLELFGATEPDRACVEEGADVAVPDQSNPQRPGHSGPCRHGSMFRTSFLISSSV
>NC_013595.1|WP_012893087.1|7306522_7306945_+|hypothetical-protein
MAAPQAEPTWQSISMLAMLTAHVEDGVTMVREQRATLERGLATPYVLDDAIVARVKRLFTQTAADNEIFAEQGWRWAAADMSAEQRCGVERYAALVEQMQAETTMILAIADELAKGTIETVLAKSDLELGIEALLRGGRL

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Crispr_ID: NC_013595_37

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_37

7394922-7395024

Orphan

Consensus_repeat	Method
CCCGGGCAGGCACGGCCCTCCGGGCAGGACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_37

>merge|NC_013595|37|7394922-7395024|CRISPRCasFinder
CCCGAGCGGGAGCGGCCCTCCGGGCAGGATCAGGCTCTGGACGGTCTCTGGCAGGATCAGGCTCCCGAGGGACCCGGACAGGCACGACCCTCCGGACAGGACC

>NC_013595|37|35|7394922-7395024|CRISPRCasFinder
CCCGAGCGGGAGCGGCCCTCCGGGCAGGATC	AGGCTCTGGACGGTCTCTGGCAGGATCAGGCTCCCGAGGGA
CCCGGACAGGCACGACCCTCCGGACAGGACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012893162.1\|7396944_7397541_+\|DUF3000-domain-containing-protein	unknown	unknown	gnl\|CDD\|378665
NC_013595.1\|WP_012893168.1\|7403234_7404227_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_013595.1\|WP_148269275.1\|7390804_7391413_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893159.1\|7392359_7393799_-\|protoporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|237009
NC_013595.1\|WP_012893149.1\|7382317_7383040_+\|pyrimidine-reductase-family-protein	unknown	unknown	gnl\|CDD\|184482
NC_013595.1\|WP_012893170.1\|7405569_7407642_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|236864
NC_013595.1\|WP_012893164.1\|7399191_7400334_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_013595.1\|WP_012893163.1\|7397537_7398764_+\|ribonuclease-D	unknown	unknown	gnl\|CDD\|223426
NC_013595.1\|WP_012893151.1\|7384243_7384600_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893152.1\|7384870_7386310_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143432
NC_013595.1\|WP_012893150.1\|7383154_7384195_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|236191
NC_013595.1\|WP_012893153.1\|7386393_7388628_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NC_013595.1\|WP_012893155.1\|7390094_7390496_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|376583
NC_013595.1\|WP_012893165.1\|7400333_7401464_+\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|368783
NC_013595.1\|WP_012893161.1\|7395222_7396260_-\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NC_013595.1\|WP_086012436.1\|7391626_7392268_-\|chlorite-dismutase-family-protein	unknown	unknown	gnl\|CDD\|377705
NC_013595.1\|WP_012893169.1\|7404373_7405573_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NC_013595.1\|WP_012893154.1\|7388744_7389749_-\|DNA-polymerase-domain-containing-protein	unknown	unknown	gnl\|CDD\|240135
NC_013595.1\|WP_043653358.1\|7402477_7403161_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893166.1\|7401460_7402318_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012893162.1\|7396944_7397541_+\|DUF3000-domain-containing-protein	gnl\|CDD\|378665	pfam11452, DUF3000, Protein of unknown function (DUF3000). This is a bacterial family of uncharacterized proteins.	8.34784e-89
NC_013595.1\|WP_012893168.1\|7403234_7404227_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.11873e-89
NC_013595.1\|WP_012893164.1\|7399191_7400334_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	3.1563e-55
NC_013595.1\|WP_012893159.1\|7392359_7393799_-\|protoporphyrinogen-oxidase	gnl\|CDD\|237009	PRK11883, PRK11883, protoporphyrinogen oxidase; Reviewed.	1.29583e-150
NC_013595.1\|WP_012893149.1\|7382317_7383040_+\|pyrimidine-reductase-family-protein	gnl\|CDD\|184482	PRK14059, PRK14059, pyrimidine reductase family protein.	2.14193e-85
NC_013595.1\|WP_012893170.1\|7405569_7407642_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|236864	PRK11154, fadJ, fatty acid oxidation complex subunit alpha FadJ.	2.34553e-109
NC_013595.1\|WP_012893163.1\|7397537_7398764_+\|ribonuclease-D	gnl\|CDD\|223426	COG0349, Rnd, Ribonuclease D [Translation, ribosomal structure and biogenesis].	9.25397e-83
NC_013595.1\|WP_012893152.1\|7384870_7386310_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143432	cd07114, ALDH_DhaS, Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like. Uncharacterized aldehyde dehydrogenase from Candidatus pelagibacter (DhaS) and other related sequences are present in this CD.	0
NC_013595.1\|WP_012893150.1\|7383154_7384195_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|236191	PRK08224, ligC, ATP-dependent DNA ligase; Reviewed.	0
NC_013595.1\|WP_012893153.1\|7386393_7388628_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	5.05659e-105
NC_013595.1\|WP_012893155.1\|7390094_7390496_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|376583	pfam01641, SelR, SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.	2.19489e-77
NC_013595.1\|WP_012893165.1\|7400333_7401464_+\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|368783	pfam06187, DUF993, Protein of unknown function (DUF993). This family consists of several hypothetical bacterial proteins of unknown function.	0
NC_013595.1\|WP_012893161.1\|7395222_7396260_-\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	0
NC_013595.1\|WP_086012436.1\|7391626_7392268_-\|chlorite-dismutase-family-protein	gnl\|CDD\|377705	pfam06778, Chlor_dismutase, Chlorite dismutase. This family contains chlorite dismutase enzymes of bacterial and archaeal origin. This enzyme catalyzes the disproportionation of chlorite into chloride and oxygen. Note that many family members are hypothetical proteins.	2.44338e-98
NC_013595.1\|WP_012893169.1\|7404373_7405573_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.9437e-151
NC_013595.1\|WP_012893154.1\|7388744_7389749_-\|DNA-polymerase-domain-containing-protein	gnl\|CDD\|240135	cd04865, LigD_Pol_like_2, LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-homologous end joining (NHEJ)-mediated repair of DNA double-strand breaks (DSB). NHEJ-mediated DNA DSB repair is error-prone. It has been suggested that LigD Pol contributes to NHEJ-mediated DNA DSB repair in vivo, by filling in short 5'-overhangs with ribonucleotides; the filled in termini would then be sealed by the associated LigD ligase domain, resulting in short stretches of RNA incorporated into the genomic DNA. The Pol domains of PaeLigD and Mycobacterium tuberculosis (Mt)LigD are stimulated by manganese, are error-prone, and prefer adding rNTPs to dNTPs in vitro; however PaeLigD and MtLigD belong to other subgroups, proteins in this subgroup await functional characterization.	1.36752e-124
NC_013595.1\|WP_012893166.1\|7401460_7402318_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	4.93086e-31

>NC_013595.1|WP_012893159.1|7392359_7393799_-|protoporphyrinogen-oxidase
MEGNRCHVVVVGGGIAGLAAAWYLRQGGEGVRVTVLDGARRVGGKLLATEVAGVSADAGAEAMLARRPEGKELARMVGLGEELRHPGTTQAAILSRGALRPMPKGHVMGVPSDLASLARSGILSPGGLARVPLDQILPATLVGTDVSVAAYIRARMGGEVVERLIEPLLGGVYAGKADRLSLDATMPRIAIAARSERSLLAATREIAAEAPKDAGPVFTTLRRGMGSLPEAVAAASGAEIRTGVMVREMRRTESGWQLVAGPVPEPEVIEADAVIVATPGPSASRLLAGEAPLAAAELARIDYASMAIVTLAYPREAFPRPPDGSGYLVPPVDGRPIKAATFSSVKWPHLAEADPNLILLRCSIGRLGEEAVLQRDDAELVALAMAEMVEVMGVRGLPRDSRVTRWGGSLPQYDVGHLDRVARIRAAVAAQPGLALCGAAYDGVGIPACVSTARTAAARILDHLDPTGEWQKRADSLTS
>NC_013595.1|WP_086012436.1|7391626_7392268_-|chlorite-dismutase-family-protein
MWSVFKLTERCPGNREGMADEVDDLLAQMAEKDVVTRGLYDVTGFRADADFMFWWHAPSAEDLQETYARFRRTDLGLLTEPVWSAMALHRPAEFNKSHIPAFLAEEEARRYVSVYPFVRSLEWYLLDDAERRRMLAEHGKMARDYPDVRANTVACFSLNDYEWMLAFEADDLHRIVDLMRTLRAAEARRHTREETPFFTGIRKPVSELIAALP
>NC_013595.1|WP_148269275.1|7390804_7391413_-|hypothetical-protein
MTRGEDLARSTGRADARRKRKIRSRVLEVSVGVTALAVAGLALGGSLLRPGPQSQAQSREAAGAALAAPPDAAAGGGPVMAARPDAKKRAADEAKAAGLSKHSDKKAFAYFEGHKATKRVKDIRIVGGYLRIYTDLPESAGNSKQALKLCETGVNYLVGELGVSSPVVFVQAKFGENGNPVLANILGPDDSDCRVTHPEPGG
>NC_013595.1|WP_012893155.1|7390094_7390496_+|peptide-methionine-(R)-S-oxide-reductase-MsrB
MDKVVKSDAEWRVQLSPEEFHVLRQAGTERPFTGEYVDTKTEGVYSCRACGAELFRSDTKFESHCGWPSFYEPSESEAVTLIEDRSLGMTRVEVRCAACDSHLGHVFHGEGYATPTDDRYCINSVSLRLEPTD
>NC_013595.1|WP_012893154.1|7388744_7389749_-|DNA-polymerase-domain-containing-protein
MASPYIELTVGDRVVKVTNPDKVYFPEIGATKRDLVEYYVSVGEGALRALYDRPTYLKRHPDGVETEGIYQKRMPPRHPEWLQTVTVRFPSGRTADALRVTEVAAIAYCANLGTVDFHPWPVRSCDVDHPDELRIDIDPQPGTGFEEARRVAFAVNEILGELGMTGFPKTSGSRGIHVSLRIEPRWDFTQVRHAAIAFAREVESRVPDLATTAWWKEERGERVFIDYNQNARDRTVAAAYSVRAKPHAPVSTPLTWEELVDADPRDFDIRTVPARFAKLGDVHAAIDDRAFSIEPLLEWFERDDRGDMPYPPNYPKMPGEPKRVQPSKARDDSR
>NC_013595.1|WP_012893153.1|7386393_7388628_+|acyl-CoA-dehydrogenase
MGIAITEEHRALAASVHGFAGRNITARGMDHEPFRAALAAQGLLGLHLPERYGGQGGGLQELAVALEALGEHCTPGSHLPTVLASAVIARATAAHPLPPAPAPPVDAPPVDVPALDARPVDVPALDTPAARVPPARDASLPVHDLLAGLAGGTLTAAVALPGGTRAAAAGPAATALGSPGADLFVLPLPDGRWAALDRADCAAEAVDGIDLSRRLTAVTARAVPDDRVLGGVTSGLVADLAAVLLGAEACGVAAWAVAAAAGHARVREQFGRPIGQFQGVKHKCAAMLVALEHARAAVWDAARALDGDGPPDEAALAAGTAGVLAADAAVRCAADAIQVLGGIGYTYEHDAHLYYRRALSLRALSGDPGEWAERVAGLAAGGVRRRMEPDLPEEAGALREGIRASVASLAGAEPLDRLVRLADEGWIMPHLPRPWGRAASPLEQVVIHQEFRDLKRPNLGIAAWAVPSIVRYGTPQQQERFLPRTLTGEIMWCQLFSEPGAGSDLASLTTKALRVEGGWSLSGQKIWTSLAQWAQWAICLARTDSDAPKHEGITYFLVEMSSPGVTVRPLKEINGEEVFNEVFLDDVFVPDELVVGQVGQGWRVARDTLSHERVALGDTWGPGSRHTDMVRLIGELGGPGALRPAALEESGRLWASGQALSALGLRVTLSQLSGGDSGTASSVRKLLGMRHSQAVSEFCWSLAPASPYWNRMILTTRAFTIGGGTTEVQLNIIAERALGLPRDP
>NC_013595.1|WP_012893152.1|7384870_7386310_+|aldehyde-dehydrogenase-family-protein
MNEYRNLIGGRLVAAADGRTLDSVNPATGEVWARVPASGRADAEAAVAAAREAFPKWSALPALGRAHFLREVAGVFAAHAEELARIETTDNGRILRDTLKKDLPGMTHLWQIAAGQVLDAVKGETVILGPGSLGLTRREPYGVALCIIPWNSPISTFSAKAAYALAAGNTVIVKPAEQACASVLRLGELLAGVLPPGVLNIVSGLGEDVGDPLVRHRGVNKISLTGSTQTGQAITRASADHLKPLTFELGGKSPNIVFPDADLDAAAQGVTVNSIYTGNAGQVCVAGSRILIHRSVWDEMIERITSIAARVRLADPLDMATTMGPIVSEGQYERVTSYLDIAEKEGAELVFGGQTGADVVPSMPDGYWVAPTLFATSDNALRVCQEEIFGPVAVAIPFDTDDEALAVSNDSSYGLAAGVWTRDLGRAHRFVRDLQSGTVWVNTFRQMPPGLPFGGVKDSGYGHDAVLEYTREKAAIIQT
>NC_013595.1|WP_012893151.1|7384243_7384600_+|hypothetical-protein
MVRSSSSDDELRAAVAARRELGPEYEDSLVEGFLEKMDQEIDRRVDDRIAARSRKDTPAVRPSVDAGQRLALSIVSLVFGVPATAGIAASTDGGIVLILILWLGIVGVNATFALGRRR
>NC_013595.1|WP_012893150.1|7383154_7384195_+|ATP-dependent-DNA-ligase
MRLPIAPPLAPMLAKAVRSLPPQDGTLFYEPKWDGFRCVVFRDGDEVYLGSRNERPFTRYFPELVEAVRAELPDRVVVDGEIVVRDGQTLDFEALQQRIHPAASRVRLLAGQTPASFVAFDLLALGEESLLDVPFAARRTRLESIFGGAGHAVRLTPITTSEERAAEWFAAFEGAGLDGIVVKPGGLPYQPDKRVMSKVKHERTADVVVAGYREHKSGPVVGSLLLGLHDAEGVLHHVGVAASFTMKRRAELVEELAPYVSRDGDHPWSAASLPGAISKWSATKDLSFVPLRSELVVEVAYDHMEGRRFRHTAQFRRWRPDRTPESCTYEQLERPVSYDLDDILTG
>NC_013595.1|WP_012893149.1|7382317_7383040_+|pyrimidine-reductase-family-protein
MRLIHPAAVGDVDLAQAYAYPDGPCVRVNMVASADGGTWLEGLSGGLSGGGDRRIFGVLRGLADVVVVGAATVRTEGYGPARPRESWRPLREGRPAAPPVAVVTRRLDLDLTGPLFAEAEPYARTIVITCEAAPAERREEAAGHADVIVAGRDRVDLAAAVKELGERGLGRVLCEGGPKINAQLAAAGLVDELCLTLSPMLIGGDAARILDGPASLTRLRLAHVLEEEGFLFTRYIRKSR
>NC_013595.1|WP_012893161.1|7395222_7396260_-|uroporphyrinogen-decarboxylase
MTPELADSPFLRACRRLPVSRTPVWFMRQAGRSLPEYRAVRGEVPMLTACATPELIVEITMQPVRRYGVDAAIFFSDIVVPLKAIGIDLDIKPGVGPVVAEPIRDAAAIETLRPIEPGDVSYVTEAVRALTGELGPTPLIGFAGAPFTLASYLIEGGPSKNHDHTKAMMYGEPRLWHAMMERLTGITLEFLRIQIAAGASAVQLFDSWVGAVAPEDYREFVLPHTSRIFAGLADLDVPRIHFGVGTGELLALLGEAGADVVGVDWRVPLDEAARRVGPGKALQGNLDPATLFAPWEVVERRAADILARGAKAEGHIFNLGHGVPPSTDPDQLARLTDFVHRASAR
>NC_013595.1|WP_012893162.1|7396944_7397541_+|DUF3000-domain-containing-protein
MTLGDAPPAPAAFRRAAATLRPAEVRPEIELEDIPAPQRLAPYSAAIGASVYRDDDELAVGRLIMLFDPDGQRGWDGPFRLVAYVRADMEPEITEDPLLGPVAWSWLTESLDAHGAGYAAAGGTVTRAVSEGFGNKAEDPVTTELELRASWSPLEEDLSGHVAAWCDLMCLAAGIPPLPPDVATLPPRRREDPEPFRT
>NC_013595.1|WP_012893163.1|7397537_7398764_+|ribonuclease-D
MTDETTIVPLLEPREGIPPVIEDPAGLARVVRAFAEGTGPVAVDAERASGYRYSGRAYLVQLRRAGAGSALIDPTYCPDLSELDTVLAGAEVVLHAASQDLPCLAELGFHPRELFDTELAGRLLGYERVGLGMMVENVLGLKLEKGHSAADWSTRPLPEDWLRYAALDVEVLVELRDVLHEELKTSGKLAWAQEEFASVLAYKSPAPRSDPWRRTSGIHKVRSLRGLAVVRELWTLRDEFARESDIAPGRVLPDSAIVTAALELPRTTKALTEIPPFTGRSARRHLRDWLAAIGRGRALPDSELPQPSTPGDGPPPANRWMDRDPVAARRLAAARAVVAALADEHHMPTENLVQPDAVRRLTWEPPSVIDEGTISARLRELGAREWQIGLTAHPMAKALIRLETKGEI
>NC_013595.1|WP_012893164.1|7399191_7400334_+|Gfo/Idh/MocA-family-oxidoreductase
MSPRSIGVVMNGVTGRMGYRQHLVRSVLAINEQGGVALSDGSRVTLKPVLVGRSPEKLARLAAEHGIADWTTDLDAALADDGNLIYFDAQVTQARVKAVLKAIEAGKHIYAEKPTAETFEEALALAEAATARGVKNGVVQDKLFLPGLLKLKRLIDGGFFGRILSVRGEFGYWVFEGDWQAAQRPSWNYRAEDGGGIVLDMFPHWAYVLENLFGRVRSVYAQAVTHIPERVDEEGRTYPATADDAAYGVFELENGIVAQINSSWNVRVHRDELVEFQVDGTHGSAVAGLRDCRVQHRATTPKPVWNPDLPVTARFRDGWQEVPDNADFDNGFKIQWEMFVRHVIEDAPFPHDFASGARGVRLAELGLRSSAEGRRLPVEP
>NC_013595.1|WP_012893165.1|7400333_7401464_+|dihydrodipicolinate-synthase-family-protein
MRITLPGGEHTLREPVTWARPPGPAKSRTVYAAAHVVADPLGDNTPGSPAAVDWDATLRFRRHLWSHGLRVADAMDTAQRNMGLDWAATRELIGRSAAEAAAFGDPAALVACGAGTDHAPRAGTLDEVVAAYTEQIETVRNAGAGVVVMASRQLAGIARGPEDYHTVYGKLLSQVDRPVILHWLGEMFDPHLAGYWGSGDVAEATASFLALIGEHAPMVDGVKVSLLDAEHEIGLRAALPEGVRLYTGDDFNYPSLIKSGSHALLGIFDAIAPAAAAALHALDAGDLDGYDEIMDPTVALSRKIFEAPTYNYKTGIVFLAWLNGHQDAFCMVNGAQAARSLPHLSEVFRLADRAGLLADPGLAVSRMRSLLAVHGL
>NC_013595.1|WP_012893166.1|7401460_7402318_+|sugar-phosphate-isomerase/epimerase
MSAETGGGRAVSRFALNQWTTRRWSVAEAVDGCVRHGVEAIGLWRQDVAEQGLDETVELVRDAGLRVSSLCRGGFLTSGDALDDNRRAIDEAAALKAACLVMVVGGLPGVVPGEPLGAISRDLAGARERVAEALAVLAPYAGERGVRLALEPLHPMYCADRAVLSTLGQALDLADPYPVEQVGVVVDTFHVWWDPEVFRQIARAGERIASYQVCDFLSPLPADVLLGRGVMGDGVIDFAPLTTAVTEAGYTGDIEVEIFNADVWAADPDEVLPRIMTRFDELVGG
>NC_013595.1|WP_043653358.1|7402477_7403161_+|hypothetical-protein
MFEAIREWEAANPESAPSGQGEAILWALGKRDQAPISGRPASGALPTLAEARAEIDAAERVPREGRVVPADGVISALHWLIGAKDGVPMPGRRSSTGWGHLVGGRGVILRTEAEINRVAELAREGLRSMPGEREKAWCSGTVAVCEWLLGLRSKSPVRNTPRPIHGPTGLNLGMEESAAEDVSRQLGRGRQHPPAYGDGVIWTIRWLRGQITVPPMNEQGQPTLSNR
>NC_013595.1|WP_012893168.1|7403234_7404227_-|LacI-family-DNA-binding-transcriptional-regulator
MVTLEDVAQQAGVSLATASRVLNGSTRQVGASLRAKVELAAAQLGYRTNVAAQTLARGASNVIGLVVHDLTDPYFAALADGAMRVADSQGLVVMVGTTHRDPEREISYVSALNAQRVCAVLLAGSRIADPHVTRRLREELDRYRETGGRVACVGQDLLGADTVVPGNREGAAALARALAGLGHRRFAVLAGPAGLITARDRVAGFAGVLAELGLPVPQIVHGSFDRDGGYAAAAEVSGATCVFAVNDVMAVGALAAFRDRGIRVPDDISVAGFDDIVTLRDLVPALSTVRLPLTDMGARALELALDAAEEVRVEPVAGEVVLRESTRGPA
>NC_013595.1|WP_012893169.1|7404373_7405573_+|thiolase-family-protein
MPSSRDVVFVDGVRTPFGRSGPKGLYAETRADDLVIRVIRELIRRNPNLPPERVDEVAIAATTQIGDQGLTIGRSAAVLAGLPKSVPGYSIDRMCAGAMTAVTSVAGGIAFGAYDVAIAGGVEHMGRHPMGEGVDPNPRFLAEQLVDGSALVMGMTAENLHDRYPAITKERADAFALASQEKVAKAYADGRIQPDLVPMATRSAEKGWGLATADEGPRPGTTLEGLATLKTPFRPHGRVTAGNASGINDGATGCIVAASDVAEELGLAPKMRLVSYAFAGVDPEVMGVGPIPSTERALRLAGLSISDIGLFEINEAFAVQVLAFLEHFGIADDDARVNPYGGAIAFGHPLASSGVRLMTQLAREFGERPDVRYGVTTMCVGMGMGGTVIWENLGWEGKK
>NC_013595.1|WP_012893170.1|7405569_7407642_+|enoyl-CoA-hydratase/isomerase-family-protein
MTDIKELFADEVVTRAIVRDVELPYGAGTMALITLDNGFDHTKPSTFGPGGLTSLDEALDSVAGRGDLAAVGVIGKPFIFAVGADLKGAATVSERDQALRIGKLGHEVFRRLGELEVPSFAFVNGAAMGGGLEVALHCTYRTISSGVPAVALPECFLGLVPGWGGTQLLPRLIGPAAAIKLIIENPLSQNRMIKGRDAFAAGVADAMFEPADFLEESLRWAARVLRGEVTVSRTDHTAEDWSKTVADARFLVDMKLHGASPAPYRALELIELARTASRDEGFDAEDQALADLLMGDELRAGLYSFDLVQRRAKKPAGAPDKALARKVTKVGVVGAGLMASQMALLFARRLEVPVVLTDLDQARLDKGVGYVHAEIDKLLGKGRVSGDQANRLKALVTGSLTKDAFADADFVIEAVFEDLKVKQKVFAEVEEVVSAECVLATNTSSLPLTEMASSLRHPERVVGFHFFNPVAVMPLLEIIRGAETDDATLATAFSVGRSLKKSSVLVKDAPAFVVNRLLTRFMGEVIGAVDEGTPLEVADHALDGLGLPMTPFTLLQLVGPAVALHVAETMHAAFPARYGVSDNLARLVAAGKPGVYAPDFSLDAEAVALFSGGTSPSTAEEVRLRALRALEEEIRLMLDEGVVAAAQDIDLCMILGAGWPFHLGGITPYLDRTGIAEPRFLPPGVASVPA

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Crispr_ID: NC_013595_38

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_38

7414819-7414970

Orphan

Consensus_repeat	Method
TGCGCAAGGGACAGGACGAGCTCCGG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_013595_38

>merge|NC_013595|38|7414819-7414970|CRISPRCasFinder
TGCGCAAGGGACAGGACGAGCTCCGGACGGTCACCGATGAGCTCCGGGCGAGCACCCAGGAGTTGCGCAAGGGACAGGACGGGCTCCGGTCGAGCATCGCCGAGCTCCGCATCACCACCGTGGCACTCCGGATCGGGCAGGACGAGCTCCGC

>NC_013595|38|36|7414819-7414970|CRISPRCasFinder
TGCGCAAGGGACAGGACGAGCTCCGG	ACGGTCACCGATGAGCTCCGGGCGAGCACCCAGGAGT
TGCGCAAGGGACAGGACGGGCTCCGG	TCGAGCATCGCCGAGCTCCGCATCACCACCGTGGCAC
TCCGGATCGGGCAGGACGAGCTCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012893168.1\|7403234_7404227_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_013595.1\|WP_052317086.1\|7410009_7410666_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NC_013595.1\|WP_052317087.1\|7412697_7413513_+\|neutral-zinc-metallopeptidase	unknown	unknown	gnl\|CDD\|225203
NC_013595.1\|WP_012893184.1\|7423689_7424418_-\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|377294
NC_013595.1\|WP_012893180.1\|7417669_7418434_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NC_013595.1\|WP_012893170.1\|7405569_7407642_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|236864
NC_013595.1\|WP_148269744.1\|7428334_7428988_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_013595.1\|WP_043653367.1\|7415187_7416390_-\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NC_013595.1\|WP_012893183.1\|7420729_7423501_-\|aconitate-hydratase-AcnA	unknown	unknown	gnl\|CDD\|236445
NC_013595.1\|WP_012893186.1\|7426755_7428039_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_013595.1\|WP_012893172.1\|7408398_7409868_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129987
NC_013595.1\|WP_012893174.1\|7410610_7412530_-\|1-deoxy-D-xylulose-5-phosphate-synthase	unknown	unknown	gnl\|CDD\|235470
NC_013595.1\|WP_012893176.1\|7413621_7414401_+\|neutral-zinc-metallopeptidase	unknown	unknown	gnl\|CDD\|225203
NC_013595.1\|WP_012893171.1\|7407911_7408346_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366264
NC_013595.1\|WP_012893169.1\|7404373_7405573_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NC_013595.1\|WP_012893182.1\|7420154_7420358_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893181.1\|7418495_7419611_-\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380650
NC_013595.1\|WP_043653358.1\|7402477_7403161_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893185.1\|7424631_7426593_+\|ricin-type-beta-trefoil-lectin-domain-protein	unknown	unknown	gnl\|CDD\|238092
NC_013595.1\|WP_012893179.1\|7416425_7417673_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226669

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012893168.1\|7403234_7404227_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.11873e-89
NC_013595.1\|WP_052317086.1\|7410009_7410666_+\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	2.12938e-19
NC_013595.1\|WP_052317087.1\|7412697_7413513_+\|neutral-zinc-metallopeptidase	gnl\|CDD\|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	2.60068e-21
NC_013595.1\|WP_012893184.1\|7423689_7424418_-\|metal-dependent-hydrolase	gnl\|CDD\|377294	pfam04307, YdjM, LexA-binding, inner membrane-associated putative hydrolase. YdjM is a family of putative LexA-binding proteins. Members are predicted to be membrane-bound metal-dependent hydrolases that may be acting as phospholipases. It is a member of the SOS network, that rescues cells from UV and other DNA-damage. Expression of YdjM is regulated by LexA.	4.2775e-10
NC_013595.1\|WP_012893180.1\|7417669_7418434_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	9.57885e-108
NC_013595.1\|WP_012893170.1\|7405569_7407642_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|236864	PRK11154, fadJ, fatty acid oxidation complex subunit alpha FadJ.	2.34553e-109
NC_013595.1\|WP_148269744.1\|7428334_7428988_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	7.2316e-23
NC_013595.1\|WP_043653367.1\|7415187_7416390_-\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	4.68299e-56
NC_013595.1\|WP_012893183.1\|7420729_7423501_-\|aconitate-hydratase-AcnA	gnl\|CDD\|236445	PRK09277, PRK09277, aconitate hydratase AcnA.	0
NC_013595.1\|WP_012893186.1\|7426755_7428039_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.57761e-49
NC_013595.1\|WP_012893174.1\|7410610_7412530_-\|1-deoxy-D-xylulose-5-phosphate-synthase	gnl\|CDD\|235470	PRK05444, PRK05444, 1-deoxy-D-xylulose-5-phosphate synthase; Provisional.	0
NC_013595.1\|WP_012893176.1\|7413621_7414401_+\|neutral-zinc-metallopeptidase	gnl\|CDD\|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	3.35038e-20
NC_013595.1\|WP_012893171.1\|7407911_7408346_+\|hypothetical-protein	gnl\|CDD\|366264	pfam00720, SSI, Subtilisin inhibitor-like.	1.29059e-21
NC_013595.1\|WP_012893169.1\|7404373_7405573_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.9437e-151
NC_013595.1\|WP_012893185.1\|7424631_7426593_+\|ricin-type-beta-trefoil-lectin-domain-protein	gnl\|CDD\|238092	cd00161, RICIN, Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ligand binding occurs on exposed surfaces of the compact domain sturcture.	1.6813e-20
NC_013595.1\|WP_012893181.1\|7418495_7419611_-\|substrate-binding-domain-containing-protein	gnl\|CDD\|380650	cd19995, PBP1_ABC_xylose_binding-like, periplasmic xylose-like sugar-binding component of the ABC-type transport systems. Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	5.55068e-104
NC_013595.1\|WP_012893172.1\|7408398_7409868_-\|amino-acid-permease	gnl\|CDD\|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.2103e-129
NC_013595.1\|WP_012893179.1\|7416425_7417673_-\|ABC-transporter-permease	gnl\|CDD\|226669	COG4214, XylH, ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism].	7.45914e-78

>NC_013595.1|WP_012893176.1|7413621_7414401_+|neutral-zinc-metallopeptidase
MRTPLISLLSGVLASLLFAGTAGAGVAEQSGPVPTGKAALTGNPIYKSGKLDLKKCEEQPVRPDDLDSSRIYLEFLMDCLNESWEYQFSKAKLPFSKPRLETISRIGRPTGCGDFPEGAQAVYCPINKKITFFLSPSILSQPTELFLFQVMAHEYGHHVQQLSGIMGAVDGRKYKSAKEFLPVLRKVELQAECLSGAFIGSVWQSLDRRQSDFTYVLRAAYDTASHGKAANIAYWLKRGFDQEGPGACNTFSAPKSKVA
>NC_013595.1|WP_052317087.1|7412697_7413513_+|neutral-zinc-metallopeptidase
MAFSLVTGVGTANAATPSTAKTSVTETAKASVTKEQAPPRGRAAATTNPLYRTGTLPNLRCATGQIRAGSAASYRTFMTRVNRCLNLMWKTQFRKAKLPFAQPKLRFVTSRVSSPCGRWPSGAGGYYCSSNRTMYIGVTRAVLKNPYGPNHAQFMAHEYAHHVQQLAGIMNYYGQSVWRARSSTKLAFSRRLELQADCLGSAFLRQVADDLPVEQEQWDAMVRWVDENGHKSWPTNDHGKGRSQAYWMERGFNAASPSACNTWTASSRSVA
>NC_013595.1|WP_012893174.1|7410610_7412530_-|1-deoxy-D-xylulose-5-phosphate-synthase
MSERTGRPGSLLESVKGPRDLKLLGAAELPRLAAEIRDLLVSSTARTGGHLGPNLGVVELTIALHRVFDSPRDRILWDTGHQAYVHKMLTGRAGLFDTLRQEGGLSGYPSQAESEHDIVENSHASTALSYADGLAKAYKVRRENDRTVVAVIGDGALTGGMAWEALNNIAAHRDLPLIIVVNDNGRSYSPTIGGLASHLASLRATQRYEDVLEFVKDNLAKVPVVGPPVYDALHGVKKGIKDVLAPQVMFEDLGLKYIGLVDGHDEQAVEAALRKARGFRRPVIVHVLTKKGFGYSFAENHDEDCFHSPTPFDPLTGEEKPKPHGWTNVFSQEIVRLGAERQDIVAITAAMLGPTGLIPFSEAYPDRLYDVGIAEQHALTSAAGLALGGLHPVVALYSTFLNRAFDQLLMDVALHRLPVTVVLDRAGVTGDDGASHNGMWDLSILQVVPGLSIAVPRDEPRLRELLAEAVRVDDGPTVIRYPKGPVTAEIEAVGQLGGMDVLRAGDPDVLIVSVGPMAEMCLEAAALLDAQGISTTVVDPRWVKPLDEALVLAAGAHKLVVVVEDSGRVGGVGDAVARTLRDADVDVPVRTYGIPQRFLDHAKRAKILSEIGLTSQDIAREITEAVAKRSAVLENHPAR
>NC_013595.1|WP_052317086.1|7410009_7410666_+|DedA-family-protein
MLLDMLGQLDPYLVGAVLLAVLALDGSLLIGAVLPGDAAIVVAGTALTGPAEIAVAAVAGVIGCYLGATGGWMIGRRYGSRVRHSRAGRWIGEHRWARAERMATGEGGGPALAASYFLPVVNALTPVLAGTLGVPYSRFIRWALAGSVAWVSTYLVLGSLAGEFVRQNEHLMVPVAGCVAILAAGLAVISRRARADRRAQVSEPGGSPAPQTVSPPPQ
>NC_013595.1|WP_012893172.1|7408398_7409868_-|amino-acid-permease
MEVFRVKSIEQSIQDTEEPEHRLRKDLSALDLTVFGIGVIVGTGIFVLTGRVARDLAGPAVALSFVAAGIVCALAALCYAEFASTVPVAGSAYTFAFATLGEFPAWIIGWDLMLEMMLGAAVVAVGWSGYLTSLLESLGIVLPDAIAGEGATFNLPAALVVLALTAILVAGIKLSSRFNLIIVTIKIAVVLLVIVAGLFFINMANYTPFIPPSKPTPAVEGLAAPLIQVLFGITPVAFGVLGIFSAAAIVFFAYIGFDVVATAAEETRDPRRDLPIGIIASLVICTLLYVAVSLVVVGMQPYSQLSESAPLADAFKAVGQTWAATLISIGALAGLTTVVMILMLGMSRVMFAMSRDNLLPRGLSKVHPRFGTPYRITILMGVIVAVLAGLVPLSTIAELVNIGTLFAFVIVSIAVVILRRTRPDLPRSFRTPLVPLVPILSVLACLYLMLNLPVETWLRFVVWMIIGVVVYVTYGYRHSRVTRRPLDSR
>NC_013595.1|WP_012893171.1|7407911_7408346_+|hypothetical-protein
MRTVKIVSAAAVFAFATALPPAASPASERPPVPPAASDRSPVPGGGSALTLTLSVADGTGGGVSLTCDREGGSHPDPFTACGLLRKVGGDLSKLTYDIDMICPEEYLPHTVRALGTWEGRPVWFDRTYDNRCEMTALTGPLFHI
>NC_013595.1|WP_012893170.1|7405569_7407642_+|enoyl-CoA-hydratase/isomerase-family-protein
MTDIKELFADEVVTRAIVRDVELPYGAGTMALITLDNGFDHTKPSTFGPGGLTSLDEALDSVAGRGDLAAVGVIGKPFIFAVGADLKGAATVSERDQALRIGKLGHEVFRRLGELEVPSFAFVNGAAMGGGLEVALHCTYRTISSGVPAVALPECFLGLVPGWGGTQLLPRLIGPAAAIKLIIENPLSQNRMIKGRDAFAAGVADAMFEPADFLEESLRWAARVLRGEVTVSRTDHTAEDWSKTVADARFLVDMKLHGASPAPYRALELIELARTASRDEGFDAEDQALADLLMGDELRAGLYSFDLVQRRAKKPAGAPDKALARKVTKVGVVGAGLMASQMALLFARRLEVPVVLTDLDQARLDKGVGYVHAEIDKLLGKGRVSGDQANRLKALVTGSLTKDAFADADFVIEAVFEDLKVKQKVFAEVEEVVSAECVLATNTSSLPLTEMASSLRHPERVVGFHFFNPVAVMPLLEIIRGAETDDATLATAFSVGRSLKKSSVLVKDAPAFVVNRLLTRFMGEVIGAVDEGTPLEVADHALDGLGLPMTPFTLLQLVGPAVALHVAETMHAAFPARYGVSDNLARLVAAGKPGVYAPDFSLDAEAVALFSGGTSPSTAEEVRLRALRALEEEIRLMLDEGVVAAAQDIDLCMILGAGWPFHLGGITPYLDRTGIAEPRFLPPGVASVPA
>NC_013595.1|WP_012893169.1|7404373_7405573_+|thiolase-family-protein
MPSSRDVVFVDGVRTPFGRSGPKGLYAETRADDLVIRVIRELIRRNPNLPPERVDEVAIAATTQIGDQGLTIGRSAAVLAGLPKSVPGYSIDRMCAGAMTAVTSVAGGIAFGAYDVAIAGGVEHMGRHPMGEGVDPNPRFLAEQLVDGSALVMGMTAENLHDRYPAITKERADAFALASQEKVAKAYADGRIQPDLVPMATRSAEKGWGLATADEGPRPGTTLEGLATLKTPFRPHGRVTAGNASGINDGATGCIVAASDVAEELGLAPKMRLVSYAFAGVDPEVMGVGPIPSTERALRLAGLSISDIGLFEINEAFAVQVLAFLEHFGIADDDARVNPYGGAIAFGHPLASSGVRLMTQLAREFGERPDVRYGVTTMCVGMGMGGTVIWENLGWEGKK
>NC_013595.1|WP_012893168.1|7403234_7404227_-|LacI-family-DNA-binding-transcriptional-regulator
MVTLEDVAQQAGVSLATASRVLNGSTRQVGASLRAKVELAAAQLGYRTNVAAQTLARGASNVIGLVVHDLTDPYFAALADGAMRVADSQGLVVMVGTTHRDPEREISYVSALNAQRVCAVLLAGSRIADPHVTRRLREELDRYRETGGRVACVGQDLLGADTVVPGNREGAAALARALAGLGHRRFAVLAGPAGLITARDRVAGFAGVLAELGLPVPQIVHGSFDRDGGYAAAAEVSGATCVFAVNDVMAVGALAAFRDRGIRVPDDISVAGFDDIVTLRDLVPALSTVRLPLTDMGARALELALDAAEEVRVEPVAGEVVLRESTRGPA
>NC_013595.1|WP_043653358.1|7402477_7403161_+|hypothetical-protein
MFEAIREWEAANPESAPSGQGEAILWALGKRDQAPISGRPASGALPTLAEARAEIDAAERVPREGRVVPADGVISALHWLIGAKDGVPMPGRRSSTGWGHLVGGRGVILRTEAEINRVAELAREGLRSMPGEREKAWCSGTVAVCEWLLGLRSKSPVRNTPRPIHGPTGLNLGMEESAAEDVSRQLGRGRQHPPAYGDGVIWTIRWLRGQITVPPMNEQGQPTLSNR
>NC_013595.1|WP_043653367.1|7415187_7416390_-|ROK-family-transcriptional-regulator
MRAGPSQEEIRRHNLGALLRHVHLGGPTSRAELTSRMGLNRSTIMALTADLTAAGLVREELPRETGRAGRPSLVVRPESARVYVFALDVGVDRLVAARVGLGGTILDRREAVRRRGPFSLDEIVGPLAGFARQMHRKTRPDTVCVGVAAAFAGGVSRSDGVIRFGPNMGSVDVPFAEEMARRLAFGLPVTVGNDANLAALAEHTRGVGVGCRDLVYLHGDVGIGGGVIVNGQLLGGHEGFGGEIGHMIVNPKGRPCGCGSLGCLEAEAGERAVLEAAGRFGAQMGRDAVRAVVDAADRGDIVAQAALSRVGDWLGLGVANLVNVFNPEMVVFGGMLREVYLGSAAQVRSRLAVDALPPSRDSLRLRTSALGDDATLVGAAELAFAQVLADPLEVLARAGS
>NC_013595.1|WP_012893179.1|7416425_7417673_-|ABC-transporter-permease
MSATISPERKAEAPSISANVRGYAERVRGGDMGALPAVFGLVVLCTVFAVLRPSFLTAGNFANLLTQGAAVTVIAMGLVFVLLLGEIDLSAGFASGVCASILAILLTNQGLPWYVAVGAAILAGVVIGATLGSIVTKLGIPSFVVTLAAFLAFQGLVLLLIKGGTIIAIRDETILAVANKNLPPALGWGLLVAGVAAYAGLQLLRARKRAVRGLASDPISLIAVRVGALALLGGLAVYFLNVERSRNAAVVSLAGVPIVVPVIVVLLLIWTFVLRRTAFGRHLYAVGGNAEAARRAGINVDRMKISAFVICSSMAAVGGIIAASRASSVDPNTGGSNVLLYAVGAAVIGGTSLFGGKGRVLDAILGGTVVAVIENGMGLMGYSSGVKFMVTGSVLLLAAGVDALSRKRAAATGLR
>NC_013595.1|WP_012893180.1|7417669_7418434_-|sugar-ABC-transporter-ATP-binding-protein
MTPVLELRGIDKSFGPVQVLHDVAFSVYPGEVTALVGDNGAGKSTLVKCVGGIHPIDSGEYLFDGKPVQIHSPRDAAELGIEIVYQDLALCDNLDIVQNMFLGREHKRGLVLDEDTMEEMAAKTLESLSVRTVKSIRQHVASLSGGQRQTVAIAKAVLWNSKVVILDEPTAALGVAQTAQVLELVRRLADQGLAVVLISHNMNDVFAVSDRIAALYLGRMAAQVKTSDVTHAQVVELITSGRSGDLGLTNGVTV
>NC_013595.1|WP_012893181.1|7418495_7419611_-|substrate-binding-domain-containing-protein
MRKGILSLTAAAAAMTLGLTACGGESGDTTTAQNSAAPAESKAAGKVGVILPDSKSSARWETADRKYLEEAFKAAGVAYDIQNAQGDKTQFQTIADQMITNGATVLMIVNLDSGTGKAVLDKAKAQGVATIDYDRLTLNGGASYYVSFDNTKVGTLQGEGLVKCLTDKKADKPIVAELNGSPTDNNATLFKNGYDGVLKPKYDAKEYVKGPDQSVPDWDNAQAGTIFEQMLTEQPKIAGVLAANDGLGNAAIAVLKKNSLNGKVPVTGQDATVQGLQNILAGDQCMTVYKAIKKEADAGAALAIALAKGEKPAASGSVKDTESGADVPAVLLDPQAIFFDSVKDVVADGFVTKDELCAGEFAAKCTEAGIQ
>NC_013595.1|WP_012893182.1|7420154_7420358_-|hypothetical-protein
MPPSSGSARAGLAGDVRLRPAVEIMIAAWPCAALTCTGTGGVGGRERLGRLLDETFAAVPGGINLAI
>NC_013595.1|WP_012893183.1|7420729_7423501_-|aconitate-hydratase-AcnA
MSTNSFGSRDTLRVGDAGYEIYRLDAVEGSGRLPYSLKILLENLLRTEDGANITADHIRALGQWDPNAAPSVEIQFTPARVIMQDFTGVPCVVDLATMREAVRDLGGDPARINPLAPAEMVIDHSVIVDFFGGPDSFQRNVDREYERNRERYQFLRWGQTAFDEFKVVPPGTGIVHQVNIEHLARVVMIRDGKAYPDTCVGTDSHTTMENGIGVLGWGVGGIEAEAAMLGQPISMLIPRVVGFKLTGKLPAGATATDLVLTITEMLRKHGVVGKFVEFYGEGVSSVPLANRATIGNMSPEFGSTCAIFPIDGQTIDYLTLTGRSAEQVALVEAYAKAQGLWLDPEAEEPVFSEYIELDLATVVPSIAGPKRPQDRIALSDAKSAWRAAVKDYAPSIQGPLDESSDESFPASDSPAVSHESNGDKPHAPGLNGDRPRKPVQVTLADGTSFEIDHGVVTIAAITSCTNTSNPFVMMGAALLAKNAVDKGLTRKPWVKTSLAPGSQVVTGYFERSGLQPYLDKLGFNLVGYGCTTCIGNSGPLQEEISAAIQANDLAVTAVLSGNRNFEGRINPDVKMNYLASPPLVVAYALAGTMDLDLNTEPLGTGTDGEPVFLADIWPSAEDISAAVASSIDQDMFLHDYADVFKGDETWRSLPIPTGDTFEWDPASTYVRKAPYFDGMPASPEPVTDISGARVLAKLGDSVTTDHISPAGSIKPGTPAAEYLRENGVAVKDFNSYGSRRGNHEVMIRGTFANIRLKNLLLNGVEGGYTRDFTLEGGPQSFIYDASANYQAAGIPLVVLAGKEYGSGSSRDWAAKGTALLGVRAVIAESYERIHRSNLIGMGVLPLQFPEGETAESLGLTGEETFDFVGVEELNKGGVPQTVTVRADGKEFQAVVRIDTPGEADYYRHGGIMQYVLRSLLAKS
>NC_013595.1|WP_012893184.1|7423689_7424418_-|metal-dependent-hydrolase
MMGHTHALTGAIAWLGVAPTLAALPLLTESTRFIETGVMVNALTPAEFVAGALICSGAAMLPDLDHPSATIAQTFGPITWGLSKAIAWLSGGHRNATHSLLFAVGAGFGAHYLANTYPIGRDIMVVLLIGLALRAIGIGIPGKKFASAMVNIGLTVGLFAVFRSDNVGYAWLGLAVAIGCLAHVIGDCCTEKGCPVLWPMRQRWLLPWKIGIKTGRAFEQKFLAPVLSVVVLGLLYFRLAPL
>NC_013595.1|WP_012893185.1|7424631_7426593_+|ricin-type-beta-trefoil-lectin-domain-protein
MPLRLPGLVMAALVAVTGAVLAAPTAHAVQNDVRPLPAALESVRRAEAVKLYGDEAIRPMDQRKTGLVSLGDSEISGEGAFDRSLYEQGTDGPDNWCHRSKKAAIHVTGIPADATFNLACSGGQTNDITIGGTHQYNELNQGDNLAIKARNTRIKMITVVVGANDAGGPEFGPTMTGCVENRVLFKGNCWPKHSPSWAGRIDFIVPRVEKALRDIQQIMTEAGYTAADYQLVAMSYPGPASPDVEDNPNFPGWYNGGCLGYLSDLAFARNKAVPIFEQGIRRAASLAGARYLDASRLFHGREVCMDGPWVTGLHAVNGDLFNPRATQQSFHPNSAGHAAFGACLGRFYAADTTQATCMLPAGTLTPALYPGLPEFRQLRNGATGDCLDVDGNSSRNGRKLLGWACEGTRNQAFWYDPTRRSLHTELSHDRCADIDGGRLTAGTAIQVWDCNGSAAQRWTHDGARLHAADAPALCATLTGGAPGARLTLAACDSGDSRQVFTWEAKKALTYTELRSGGKCLDVPGNSPASGANLVLYTCDGNADQFWAHNPVSGQLHNLADPGFCVDLEGGTVAAGQPIQVANCSSAVGQYSASMRWNLTGGTFLSRKDTGWAIAPSGTSDGSAVVLQRAAGQRWSAGAGRAPDPWKFLTADVY
>NC_013595.1|WP_012893186.1|7426755_7428039_-|MFS-transporter
MTVQQERVSGPVRRNETALVGFTVATNLADGVAKIVLPLLAVGLTDSPGLVAGVGLALTLPWLLASLHVGVFVDRNDRRRLAAAANLIRLVVALGVLAAVAGDALSLPLLYLAAASIGLAEVVADSAVGALVPAAVPRERLGRVNAWIAGAETVANEFAGPAIGGLLVGFGAALALGSSAAAFALGAVLLALLAGRFRVSAAEERDSGGDRRPGSVRAEMVAGLVFLWRHRLLRTMSLTISALVACWSAWLALLPSYAVRLLDLDPAGYGLLLSSIGLGGLLGAVLVTTVNRLLGVRWALFVDLVGTFVMMIVPAVFPEAWAVGAAAFIGGMGGTLWTVNSRTLAQMIVPDRLLGRYGSAARLLSWGMLPIGAGLAGLLAEIVGLTGAFAIFAVVAALPVVPFLMTVTQSDIEIAQRRSELDHVILG
>NC_013595.1|WP_148269744.1|7428334_7428988_+|helix-turn-helix-transcriptional-regulator
MAAGWQQGESHHGGPGPHGWAPHEHRHRGHRGGPFGGGAFPWDFGRGGPGRGGPFGGRPPFGRGRKAKRGDVRAAILALLTEEPHNGYQIIQEIERRSEGGWKPSPGAVYPALQQLTDEGLVLSEENDGRKSFRLTEAGRAYVTEHADEVRAPWEEMTPDVDDSTWEMMNLARQSGFAMLQILQTGSDAQIRQAKQILTETRRKLYQILADGDSGEE

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Crispr_ID: NC_013595_39

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_39

7497560-7497658

Orphan

Consensus_repeat	Method
TCGCTGCGCTTTTGACCTTCCACCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_39

>merge|NC_013595|39|7497560-7497658|CRISPRCasFinder
TCGCTGCGCTTTTGACCTTCCACCCCGTACGGCGCCGCTCGGAAAAGCGGCCCCCGGCCACTCCACTCACCCTCGCTGCGCTTTTGACCTTCCCCCCGG

>NC_013595|39|37|7497560-7497658|CRISPRCasFinder
TCGCTGCGCTTTTGACCTTCCACCCCG	TACGGCGCCGCTCGGAAAAGCGGCCCCCGGCCACTCCACTCACCC
TCGCTGCGCTTTTGACCTTCCCCCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012893254.1\|7502840_7503581_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224495
NC_013595.1\|WP_012893257.1\|7506009_7507047_+\|dipeptidase	unknown	unknown	gnl\|CDD\|366534
NC_013595.1\|WP_012893247.1\|7495334_7495847_-\|DinB-family-protein	unknown	unknown	gnl\|CDD\|368218
NC_013595.1\|WP_012893252.1\|7500261_7500720_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NC_013595.1\|WP_012893242.1\|7491622_7492000_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_081453483.1\|7507058_7508282_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349881
NC_013595.1\|WP_012893243.1\|7492130_7492910_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187605
NC_013595.1\|WP_012893248.1\|7496157_7496475_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893255.1\|7503577_7504414_-\|Nif3-like-dinuclear-metal-center-hexameric-protein	unknown	unknown	gnl\|CDD\|376614
NC_013595.1\|WP_169369583.1\|7497844_7499287_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|223354
NC_013595.1\|WP_012893256.1\|7504494_7505934_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NC_013595.1\|WP_043657317.1\|7508335_7509100_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225910
NC_013595.1\|WP_012893240.1\|7490585_7491209_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013595.1\|WP_012893251.1\|7499640_7500036_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893245.1\|7493154_7494408_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_013595.1\|WP_012893249.1\|7496477_7496792_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893244.1\|7492858_7493074_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_081453482.1\|7491260_7491626_+\|thioesterase	unknown	unknown	gnl\|CDD\|223894
NC_013595.1\|WP_174435270.1\|7501485_7502883_-\|bifunctional-RNase-H/acid-phosphatase	unknown	unknown	gnl\|CDD\|180903
NC_013595.1\|WP_012893246.1\|7494409_7495126_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012893254.1\|7502840_7503581_-\|hypothetical-protein	gnl\|CDD\|224495	COG1579, COG1579, Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only].	7.91396e-25
NC_013595.1\|WP_012893257.1\|7506009_7507047_+\|dipeptidase	gnl\|CDD\|366534	pfam01244, Peptidase_M19, Membrane dipeptidase (Peptidase family M19).	1.49987e-97
NC_013595.1\|WP_012893247.1\|7495334_7495847_-\|DinB-family-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	4.60147e-38
NC_013595.1\|WP_043657317.1\|7508335_7509100_+\|hypothetical-protein	gnl\|CDD\|225910	COG3375, COG3375, Uncharacterized conserved protein [Function unknown].	2.35459e-50
NC_013595.1\|WP_012893252.1\|7500261_7500720_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	4.88713e-14
NC_013595.1\|WP_081453483.1\|7507058_7508282_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|349881	cd03885, M20_CPDG2, M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme. Peptidase M20 family, Glutamate carboxypeptidase (carboxypeptidase G; carboxypeptidase G1; carboxypeptidase G2; CPDG2; CPG2; Folate hydrolase G2; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase; E.C. 3.4.17.11) subfamily. CPDG2 is a periplasmic enzyme that is synthesized with a signal peptide. It is a dimeric zinc-dependent exopeptidase, with two domains, a catalytic domain, which provides the ligands for the two zinc ions in the active site, and a dimerization domain. CPDG2 cleaves the C-terminal glutamate moiety from a wide range of N-acyl groups, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl, and pteroyl groups to release benzoic acid, phenol, and aniline mustards. It is used clinically to treat methotrexate toxicity by hydrolyzing it to inactive and non-toxic metabolites. It is also proposed for use in antibody-directed enzyme prodrug therapy; for example, glutamate can be cleaved from glutamated benzoyl nitrogen mustards, producing nitrogen mustards with effective cytotoxicity against tumor cells.	2.59819e-122
NC_013595.1\|WP_012893243.1\|7492130_7492910_+\|SDR-family-oxidoreductase	gnl\|CDD\|187605	cd05347, Ga5DH-like_SDR_c, gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs. Ga5DH catalyzes the NADP-dependent conversion of carbon source D-gluconate and 5-keto-D-gluconate. This SDR subgroup has a classical Gly-rich NAD(P)-binding motif and a conserved active site tetrad pattern. However, it has been proposed that Arg104 (Streptococcus suis Ga5DH numbering), as well as an active site Ca2+, play a critical role in catalysis. In addition to Ga5DHs this subgroup contains Erwinia chrysanthemi KduD which is involved in pectin degradation, and is a putative 2,5-diketo-3-deoxygluconate dehydrogenase. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107,15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.06203e-71
NC_013595.1\|WP_012893256.1\|7504494_7505934_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	6.3298e-98
NC_013595.1\|WP_012893255.1\|7503577_7504414_-\|Nif3-like-dinuclear-metal-center-hexameric-protein	gnl\|CDD\|376614	pfam01784, NIF3, NIF3 (NGG1p interacting factor 3). This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.	1.68385e-86
NC_013595.1\|WP_169369583.1\|7497844_7499287_-\|FAD-binding-protein	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	3.52373e-25
NC_013595.1\|WP_012893240.1\|7490585_7491209_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.60865e-08
NC_013595.1\|WP_012893245.1\|7493154_7494408_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.18951e-34
NC_013595.1\|WP_081453482.1\|7491260_7491626_+\|thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	6.70735e-17
NC_013595.1\|WP_174435270.1\|7501485_7502883_-\|bifunctional-RNase-H/acid-phosphatase	gnl\|CDD\|180903	PRK07238, PRK07238, bifunctional RNase H/acid phosphatase; Provisional.	3.49226e-101
NC_013595.1\|WP_012893246.1\|7494409_7495126_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	9.07304e-78

>NC_013595.1|WP_012893249.1|7496477_7496792_-|hypothetical-protein
MKDEFFPTGSVSHDDPAVEWAMGTIDGLRPSEQRELVRSSYRAALSFERTGDVDHLVNFAKNLLATVHLRGIPAYAEALKSASRGTRGSGETLKVEEVLNRLME
>NC_013595.1|WP_012893248.1|7496157_7496475_-|hypothetical-protein
MAELRLQEESERVLAEWWESTRPREGDRQLVCEVLRTVLGGTWSGRWYWTQDLADDQPCFPVVTIQPRERLMVLVRFWPADDPPELELISIFEADPCQNHRIARG
>NC_013595.1|WP_012893247.1|7495334_7495847_-|DinB-family-protein
MTPPRDRPPYVADERTQLVGWLDMQRAIIHWKCEGLSDADAHRPVLPASPLMTMAGVVSHLRWTEHCWFEVLFLGRPATGPQFEGEHDDADMMVEGVPLAQLLEEYDRQCAVSNEIIAAHSLDDVGRHPDFRSAAATLRWMVIHMVEETARHAGHVDAIRELLDGEKGYY
>NC_013595.1|WP_012893246.1|7494409_7495126_-|response-regulator-transcription-factor
MSGSGGGGTPSLLLVEDDEVIRRTVAMTLERYGYEVSVAGDGLTGLELFRDGRHDLLLLDVMLPALDGIGLCRRVRESSVVPILMMSARGDSPDVVSGLEAGADDYVVKPVDTAVLVARIRSLLRRAAFAPPAPPAEQPSEPAGASLVFGDLSIDPQGLEVRRAGEPVALAPTELRLLLEFAANPGIVLDRQTLLRDVWDYGWDGDSRVVDLCVQRLRKKIGADRIETVRGFGYKLLR
>NC_013595.1|WP_012893245.1|7493154_7494408_-|HAMP-domain-containing-histidine-kinase
MSRLAPARHLLNWRSLHWKIAALTAAAACAVTAVVGVLVHRATYDWSLTIGQQKAYRALEDATVAYARTGSRGEALADPDEIPAPMLGSLRRGVTLTWYDDRKPDQPWMWAARVVDGEPLAVRMEMGPERRSLQALDRHIVMAALAALAVVVPLAALAASLPTRRLRRVAQTARRISEGELDARIGMDGRRGDEIAEISAAVDSMAGSLQRWLLNEQRFTADVAHELRTPVMGLMTSAELLPDGEVTDLVRDRVRVLRTLVECLLEISRLDAGAERADRVPVPLGEVVEESVRRTGLQAAVTVTGAPVVETDPRRLDRIIANLVINAHRHGRSPVEVAVDGTTVVVRDHGPGFPDELLAHGPQRFRTGAAERGRGYGLGLAIALGQAGVIGADLTLANAPGGGAAAVVCLPERAQRG
>NC_013595.1|WP_012893244.1|7492858_7493074_-|hypothetical-protein
MCLPAKEEIKETAREQARCRRDQGYEVGDPEDGAALRVPQDVRPEDLRKCLPGRTQCTENPPSTKIDCPVT
>NC_013595.1|WP_012893243.1|7492130_7492910_+|SDR-family-oxidoreductase
MTTQPYLSELFSLDDRVAVVTGGSSGIGRAIAGALARAGASVVVVARKEADLIATVDELAAHGCRAAWVSADLSTRDGVRLAAEKAVEAFGEPDILVNSAGINLRPPMAELNEDVWDVTMAVNLEAPYLLGQRFGPGMAERGYGRIIHISSQQAHRAFVQSGVYGVSKGGLESLARSQAEAWSSSGVTCNTLVPGFVMTALNARLSSDPEKVAALAARTMVGRNGLAEDFAGAAVFLAGRASGYVTGQSIFVDGGFSVH
>NC_013595.1|WP_012893242.1|7491622_7492000_+|hypothetical-protein
MIRSRWIPGPEPRGDGPVVVSRTDFRVHRVADLPRACRTGWRLGGLWPELAGAVGVWLWADLPRRRIGSVSVWRAESDLRAFVRHPLHVEIMRAYRDRGTLTSDTWDSPAADLWADAEDRVTARR
>NC_013595.1|WP_081453482.1|7491260_7491626_+|thioesterase
MGLLHNAHYGVLVERAISAFWTELGWHFDPARSRFKDVFLAVREFQITYHVPIMGAGEPLVHFWMERMGNTSGVYGFRVLSSDGQTVHAEGRRVNVNLDPATLRPTSFSDEIRDAAKVLAA
>NC_013595.1|WP_012893240.1|7490585_7491209_+|TetR/AcrR-family-transcriptional-regulator
MQDGRKLRGQRSREAILDQAVALASVDGLGGLTLSRLAEAAGVSKSGFFAHWRDKEQLQLDCVDRARRLWSERVIAPAATAPRGLRRLFALHESRLAFYADGVLPGGCFFFVAQVEFDDRPGPVRDSVAAAMGDWLGYLEHRVQEAVDLGELTADPAQLAYEIEALGEAAVTHARLRDSDAAYRHARRAVLDRLRVLATDPSILPED
>NC_013595.1|WP_169369583.1|7497844_7499287_-|FAD-binding-protein
MRTVTPAEFSADRLAGGQAAWHDVVSLAAPIRGRTLYPGDEGFEEACSGWLLTVEHRPAAVVVAAGADDVAAAVRFAAETGRPVAVQSTGHGKSVPADGAVFIATGELRELSVDPRAGTARIGAGLRWDEVLAAAAEHGLAPLCGSSGQVGVMGYLTGGGLPLACRTYGFAADYVRSLDIVTADGLLRTVSPAQEPDLFWAVRGGKSNFGVVVAAEIELLPLRTVYGGELHYPGEDPGHAAHVLGSYLAWVKEQPEEMSSSVTLLRLPDVPQLPEEFRGRSFVQFRVVYTGDEEQGARLMEPLRALGPEKDTCGAMPYTQITEIYQDPKNPVMVHLRSALLHELDDEAVEELVSFIDPSTPEGTFPGIELRHLGGALNRPPGRSHAVSTQGAAFHLWMRMPAPARRAADEVLERLRRWDTGAMLPGFLFDHDSAPERVRRAYTEADYRRLAALKAEYDPDHLFRVNHTIPPVSNGERTRS
>NC_013595.1|WP_012893251.1|7499640_7500036_-|hypothetical-protein
MSTDVGTAAAPRATRREWLGLAILALPAMLIAVDLTVLHLALPAPVAEAAEDTLAAAVNVARELPAAQGSGLVSVAREAFVYGLQTTAIVGAVLAVLLATVAATLAAQGPDAGPASACGGGRRGEVLREGG
>NC_013595.1|WP_012893252.1|7500261_7500720_+|winged-helix-turn-helix-transcriptional-regulator
MDTAEGTLPQRLRTLPSRLTNQAALTANRIVDQALAQAGVRRYHYKLLATLEEYGPGSQAALGRRTRIDRSDMVAIVNDLVERQLLERAPDPEDRRRNIITITAAGRGQLTRLDRLVAAAQDEFLAPLPAADRRTLVDLLTRLADHHGDKLI
>NC_013595.1|WP_174435270.1|7501485_7502883_-|bifunctional-RNase-H/acid-phosphatase
MPPHPGPHRRVRPVTSFVIEADGGSRGNPGPAGYGAVVKDAADGQVLVETAEAIGAQTNNVAEYRGLIAGLQSLLALAGDGAVVEVRMDSKLVIEQMAGRWKIKNEGLRPLALEAGALARRLRVTWQWIPREKNKDADRLANEAMDAAAKGRPWQPSGSAGTGSARPGSAGLGSARTGSAGTGSPLAGPSGAREFDLPGASDADAPSRPAPAPAPLPAVAAQDSLLDLIDSDAVSPGQDVPSGQGTAVPGTAGTGWRAPTTVATSLLLLRHGETPLSVERRFSGLGDPELTPNGIAQAEAAAARLSREPYGIQVVVSSPLKRARATAEIVAARLGLEVVVEEGLREADFGDWEGHTFTEIQRRWPDALAAWLADPSAAPPGGESFGVAARRVQATGDRLVERYEGRTVLAVSHVTPIKMLLQSALLAPLAALYRMHLDLAALSLIEYYADGPAVVKAFNDTSHLR
>NC_013595.1|WP_012893254.1|7502840_7503581_-|hypothetical-protein
MKAAPAAQKRLLDLAELDSVIDRLAHRRRTLPELAEIDEISARVARLATQVISAETEAGDLAREQSKAEADVDSVRIRAERDQKRLDSGQVSSPKDLASLQSEIASLNRRQGDLEEVVLEIMERRESADAQVTKTVAERDGLAAARGVSEDRRDAAFAEIDKESAEVRGKRAEVVTDIPADLLALYEKLRDQFGVGAAMLQGGRCLGCRTSLSIAEINRIKAASHDEVIRCEECRRILVRTAESGL
>NC_013595.1|WP_012893255.1|7503577_7504414_-|Nif3-like-dinuclear-metal-center-hexameric-protein
MPTLADVVRELESTYDPRWAESWDAVGLVCGDPSSEVRRVLFAVDPVAAVAEEALRWDADLIVTHHPLYLRGTTSVAATTFKGRLVHTLIKNDVGLFTAHTNADVADPGVSDALARAVGLTGPLTPLLPSADDPRRGLGRVGSLPAPLSLREFARRAARGLPGTAGGLRVAGDLDCEVRRVAVSGGSGDSLLGTARAAGVDVFLTADLRHHPASEFMEAPDGPALIDAAHWATEWPWLAEAARRLTSGLAGKGITVETRVSETVTDAWKTTAECEDLK
>NC_013595.1|WP_012893256.1|7504494_7505934_+|NAD(P)/FAD-dependent-oxidoreductase
MSPNIAIIGAGFGGLCMAIRLERAGIRSYTIFEKGPGVGGTWRDNTYPGAGCDIPSHLYSFSFERYASWTRRYPGQPEILDYLEMCADKYGLRPRIRLNTEVTAAAFDESLGRWRVRTAAGEQLFDVVVSGVGQLNRPRLPDIPGMPSFGGAAFHSARWDHSQDLTGRRVAVIGNGSSAAQLIPRVAEVAGHVDVFQRTPNWVIPKPDAVFGEATRTAFRHVPFLQRGYREWIYRYAEGALYRALAGGWSAGVLRRRALEHLRDQVPDPQLRARLTPGYPVGCKRVIIDSSFYPALTRANVDLVTEPITRIAPAGVETATGLREADVIVYATGFQSTDFLAPVEITGRQGRRLGEEWKDGAEAYLGIAVPHFPNLFLLYGPNTNLGHNSIVFMIECQVGYVMRCLPYLSRRGPMEVRPEAMEAWRRSLDRAMGSMVWGAGCTSWYKNAAGRVTNNWPAPTTVYRRITRAPRPAAFRFAR
>NC_013595.1|WP_012893257.1|7506009_7507047_+|dipeptidase
MSAELHRDAVVADTHNDLLMAVTARPPRQWASFFRERWLPQLHEGGVNVQVLPVFIDDQYRPEGALRQTLRMIECAHTLAEGNADTVRLCLDGTQIDQALSEGRIALVLALESAPGLDASVELLPTLYRLGVRIASIAHWGRTALADGSGEDATASRLTAAGVEAVREMERLGMIFDISHLSASGVGHVLELSTRPVMATHSSARALRDHHRNLTDDQIRAVAATGGVVCVNFLAAFLSEDPAEYTVDRLVDHIEHIVGVGGIDHVGLGPDFVREVMNDLTPPCCEGFSYSGVDNLAAIPGLAGPSGLPLVTDALLKHGFADEEIVKILGGNVLRLFRAELGRPA
>NC_013595.1|WP_081453483.1|7507058_7508282_+|M20/M25/M40-family-metallo-hydrolase
MLEDLEELVSCESFSADHEAVARSARVVADQGLRRLGTRPETIVIDGVTHLRWTFGTPRVLLVGHHDTVWPIGTLAEHPWSLVDGIARGPGVFDMKAGLVQAFHALAALPSPEGVCLLVTGDEEVGSPSSRALIEESARGCAAAFVLEAGADGGALKTARKGTSNYAVTVHGRAAHAGLEPERGANAGIELAHQILALGAIALSADDGAAPDGLGPTTVTPTVLSGGTTTNTVPALASVEVDVRVPTLAAQARVDEMVRALAPRTPGTRLEVSGGPNRPPLEQASSARLFELACRIAKDLGMEPPRGVAVGGASDGNFTAGIGCPTLDGLGAVGGGAHAAHEHVVVEEMPGRTRLLTGLIASVLGGEPPAGAVATEAAVTGEAAAGRTSPAAGSSATAGESPGEAGR
>NC_013595.1|WP_043657317.1|7508335_7509100_+|hypothetical-protein
MRIDELSELPAFEEVFRLFDDVWHPDPGNPPVTVEMMRAFSHAGNYVAGAYEGGRLVGASVGFLAAPAGQVLHSHVTGASIGRGIGFALKLHQRAWALERGLERITWTYDPLVRRNAHFNLVKLGARPEEYLPSFYGVMADAINTGDESDRTLAVWRLTEPRVLAAVRGEPHRPQIPPDAVTALAERDGRPITGRTDARTLLVAVPADIETLRRADPGAAKAWRHAVRDVLGGLMEEGAQVTGFTGEGHYIVER

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Crispr_ID: NC_013595_40

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_40

7526410-7526483

Orphan

Consensus_repeat	Method
GCCCGGCGCGGGCAGCGTCCCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_40

>merge|NC_013595|40|7526410-7526483|CRISPRCasFinder
GCCCGGCGCGGGCAGCGTCCCCTGACCGGAGATCCGGCCGGCCCCGGCACGGCCCGGCGCGGGCAGCGTCCCGT

>NC_013595|40|38|7526410-7526483|CRISPRCasFinder
GCCCGGCGCGGGCAGCGTCCCCT	GACCGGAGATCCGGCCGGCCCCGGCACG
GCCCGGCGCGGGCAGCGTCCCGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012893281.1\|7540504_7541491_+\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NC_013595.1\|WP_012893269.1\|7519102_7520116_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380519
NC_013595.1\|WP_012893270.1\|7520278_7521550_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340871
NC_013595.1\|WP_012893271.1\|7521733_7524895_-\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
NC_013595.1\|WP_012893263.1\|7512728_7513910_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173841
NC_013595.1\|WP_012893264.1\|7514081_7515425_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_013595.1\|WP_012893279.1\|7533499_7539130_-\|non-ribosomal-peptide-synthetase/MFS-transporter	unknown	unknown	gnl\|CDD\|237108
NC_013595.1\|WP_012893278.1\|7533323_7533503_-\|MbtH-family-NRPS-accessory-protein	unknown	unknown	gnl\|CDD\|225790
NC_013595.1\|WP_012893267.1\|7517100_7518090_+\|diiron-oxygenase	unknown	unknown	gnl\|CDD\|378680
NC_013595.1\|WP_012893275.1\|7529694_7531428_-\|non-ribosomal-peptide-synthase	unknown	unknown	gnl\|CDD\|380454
NC_013595.1\|WP_012893262.1\|7511751_7512732_-\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NC_013595.1\|WP_012893274.1\|7528261_7529698_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380454
NC_013595.1\|WP_169369425.1\|7515993_7516878_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|223769
NC_013595.1\|WP_012893276.1\|7531429_7532941_-\|acyl--CoA-ligase	unknown	unknown	gnl\|CDD\|223395
NC_013595.1\|WP_012893273.1\|7526861_7528265_-\|non-ribosomal-peptide-synthase/polyketide-synthase	unknown	unknown	gnl\|CDD\|380454
NC_013595.1\|WP_043657321.1\|7532937_7533153_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|223314
NC_013595.1\|WP_012893282.1\|7541487_7542678_+\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NC_013595.1\|WP_012893268.1\|7518086_7518884_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|365877
NC_013595.1\|WP_012893265.1\|7515434_7516037_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379409
NC_013595.1\|WP_012893280.1\|7539515_7540508_+\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|238958

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012893281.1\|7540504_7541491_+\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	2.49429e-69
NC_013595.1\|WP_012893269.1\|7519102_7520116_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380519	cd06296, PBP1_CatR-like, ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group includes the ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group belongs to the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.67604e-108
NC_013595.1\|WP_012893270.1\|7520278_7521550_-\|MFS-transporter	gnl\|CDD\|340871	cd17313, MFS_SLC45_SUC, Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters. This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.60707e-23
NC_013595.1\|WP_012893271.1\|7521733_7524895_-\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NC_013595.1\|WP_012893263.1\|7512728_7513910_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	5.78143e-127
NC_013595.1\|WP_012893264.1\|7514081_7515425_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.55955e-56
NC_013595.1\|WP_012893279.1\|7533499_7539130_-\|non-ribosomal-peptide-synthetase/MFS-transporter	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NC_013595.1\|WP_012893278.1\|7533323_7533503_-\|MbtH-family-NRPS-accessory-protein	gnl\|CDD\|225790	COG3251, COG3251, Uncharacterized protein conserved in bacteria [Function unknown].	5.00914e-23
NC_013595.1\|WP_012893267.1\|7517100_7518090_+\|diiron-oxygenase	gnl\|CDD\|378680	pfam11583, AurF, P-aminobenzoate N-oxygenase AurF. This family is a metalloenzyme which is involved in the biosynthesis of antibiotic aureothin by catalyzing the formation of p-nitrobenzoic acid from p-aminobenzoic acid. AurF is a non-heme di-iron monooxygenase which creates nitroarenes via the sequential oxidation of aminoarenes.	2.20633e-102
NC_013595.1\|WP_012893275.1\|7529694_7531428_-\|non-ribosomal-peptide-synthase	gnl\|CDD\|380454	cd19531, LCL_NRPS-like, LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar domains including the C-domain of SgcC5, a free-standing NRPS with both ester- and amide- bond forming activity. LCL-type Condensation (C) domains catalyze peptide bond formation between two L-amino acids, ((L)C(L)). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). In addition to the LCL-type, there are various subtypes of C-domains such as the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. Streptomyces globisporus SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. An HHxx[SAG]DGxSx(6)[ED] motif is characteristic of LCL-type C-domains.	9.20182e-68
NC_013595.1\|WP_012893262.1\|7511751_7512732_-\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	4.28042e-36
NC_013595.1\|WP_012893274.1\|7528261_7529698_-\|hypothetical-protein	gnl\|CDD\|380454	cd19531, LCL_NRPS-like, LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar domains including the C-domain of SgcC5, a free-standing NRPS with both ester- and amide- bond forming activity. LCL-type Condensation (C) domains catalyze peptide bond formation between two L-amino acids, ((L)C(L)). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). In addition to the LCL-type, there are various subtypes of C-domains such as the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. Streptomyces globisporus SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. An HHxx[SAG]DGxSx(6)[ED] motif is characteristic of LCL-type C-domains.	3.84491e-34
NC_013595.1\|WP_169369425.1\|7515993_7516878_-\|EamA-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	1.21296e-06
NC_013595.1\|WP_012893276.1\|7531429_7532941_-\|acyl--CoA-ligase	gnl\|CDD\|223395	COG0318, CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	9.72371e-114
NC_013595.1\|WP_012893273.1\|7526861_7528265_-\|non-ribosomal-peptide-synthase/polyketide-synthase	gnl\|CDD\|380454	cd19531, LCL_NRPS-like, LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar domains including the C-domain of SgcC5, a free-standing NRPS with both ester- and amide- bond forming activity. LCL-type Condensation (C) domains catalyze peptide bond formation between two L-amino acids, ((L)C(L)). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). In addition to the LCL-type, there are various subtypes of C-domains such as the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. Streptomyces globisporus SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. An HHxx[SAG]DGxSx(6)[ED] motif is characteristic of LCL-type C-domains.	1.00578e-175
NC_013595.1\|WP_043657321.1\|7532937_7533153_-\|acyl-carrier-protein	gnl\|CDD\|223314	COG0236, AcpP, Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	0.0053399
NC_013595.1\|WP_012893282.1\|7541487_7542678_+\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	8.70391e-56
NC_013595.1\|WP_012893268.1\|7518086_7518884_+\|SDR-family-oxidoreductase	gnl\|CDD\|365877	pfam00106, adh_short, short chain dehydrogenase. This family contains a wide variety of dehydrogenases.	6.27682e-64
NC_013595.1\|WP_012893265.1\|7515434_7516037_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|379409	pfam13977, TetR_C_6, BetI-type transcriptional repressor, C-terminal. This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C-terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	1.59053e-18
NC_013595.1\|WP_012893280.1\|7539515_7540508_+\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	gnl\|CDD\|238958	cd02000, TPP_E1_PDC_ADC_BCADC, Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).	1.59842e-82

>NC_013595.1|WP_012893271.1|7521733_7524895_-|non-ribosomal-peptide-synthetase
MRAPLSPEQERLWLLQRLDPDNASYTMYLVRALHGPLDQAALTWALTDVLARHESLRTRFAEEDGVPWAVVEPGAPGIEWLSLRSRQEAADLVSRRANAPFDLEAGPPLQVAVIRLADDEHLLCLTMHHIIADGWSLNVILDDLAECYTAHLHGVEPRLRPLPVQAGDYGRWQRRRAQRAVPYWTERLADPPASELPFRHRRGRSGEAATHRAGLPPATARRLERLAGENRTTLFAVLTAAYQTLLFRHTGQEDVLVGSVVAGRDRVELEPMVGYVAQTVILRGDLGGDPSFTDLVARTRGEVLGALGNSAVPFEKLGHPADSLLPSMFILHNQDAGPRRSFGGLTVTDVDAGFRQVKVDLLVEAWSDGNGLALSFLYDSGLFEAGAIGRLADRFAVLLESVAAEPGTPISALPIWTEADLADIRALATGPALATGSPSVPEPPLAASVPLDPAPGSGAAPYLVPEMIVEAVRRAPGAVAVICGEETITYGELLARADALAGALRDGGVGPGDVVGVCLPRSIEAIAALLAVWRSGAAYLPFDPDVPDERLAFSLSDSSATHVITRRRLPDGLTAVDPASGGGPDGLAGRTAAAPAEPGRAAAYVITTSGSTGVPKGVLVEHGAVAARVRWMRADYGLTSADHVVQFASLSFDAHVEEVFPTLAAGATLVLLPDGAASLPDLLASPPGGRVTVLDLPTAYWHALVEELEEVVWPPSLRLVILGGEQVSAAAVERWRGRFGDGVRLVNTYGPTEAAVIATAADLGAEAALEHPPIGRPIGATTVHVLDGRGEPLPPGATGELVIGGAGVARGYLGRPALTATAFVPDPAGEPGARRYRTGDRVRWRADGRLEFLGRLDGQLKIRGFRIEPGEVESHLLAHPGVGQAFVTGRGGELLAYVTGTVDPADLRAHLERTLPRQLVPTAWVRLEALPLTGGGKVDRAALPEPVTAPAAERVLPRTDAERLVAGIWDELLGAGPYGVLDDFFALGGHSLLATRVAARIRRATGVEVPIRTIFARSTVAALAEAVEDLLIEELAGLTEEEAMDLLAGTDSP
>NC_013595.1|WP_012893270.1|7520278_7521550_-|MFS-transporter
MSAVQPVPELPAALAEPTRRVGPWWVAGISLANLALWMGYFGPLQVLLPSQVAQVAPGGKETALAVVTGMGAAVAMLLNPVAGALSDRTSGRFGRRHPWTLAGALLGAGAMVFLAEQGTLLGMVIGWCLVQAGLNAMQASLTAGVPDHVPTGQRGEVSGWVGIPQSLGVVLAVVLVTRVVTTVESGYLLIAALIPLCVLPFVLTTSDPRLTAKPPFDLGAFLRGFWISPRAHPDFFWAWVTRFLMQLGNAIATLYLLYFLTDAVGYERLFPGEKAEDGLLLLILLYTATVVLTTVVAGVVSDRLGRRKLLVTVSGLISTVPAVMLALWPLWPVALVAAAILGVGFGVYLSVDNALVTQVLPAADGRAKDLGVINIANSGPQVLGPVVAGPIVAGSGGYPALYLTSAALVLLGALLVMRIRSVR
>NC_013595.1|WP_012893269.1|7519102_7520116_+|LacI-family-DNA-binding-transcriptional-regulator
MPAKSRVTIALIAEEAGVSVPTVSKVINGRPEVAPGTRQRVERLLHKHGYQRRVSQSDGPVGLIDLVFTEIESPWAMEIVRGAEATAREAGASTVISVLHTHAGPGRDWLERIATRRTDGVVIVASRLSAGLQGRLNARSMPFVVVDPEGEPAPHVASVGATNWNGGLAATRHLLELGHRRIGVIGGPADMLCSRARIDGYRAALETAGVPVAAELIRHGDFLVDSGHDHGHGLLALADPPTAIFAGSDLQAFGVFEAARRRGLRVPEDLSVVGFDDLPLARSAWPPLTTVRQPLRDMAALATRMVLAIGRGDRSQARRVELATELVVRESTAPPRP
>NC_013595.1|WP_012893268.1|7518086_7518884_+|SDR-family-oxidoreductase
MRTAIVTGGASGIGRALCRELARRGAHVVAADLDGAGAERVAKEFGCSAATLDVTDARAVQDLVTGVRAERGRLDLVFNNAGIAVGGTTDELTLDHWDRTIDVNLRGVVHGVHAAYPIMMRQGFGHIVNTASLAGLVPAPLMAPYTATKHAVVGLSLALRAEAAAHGVKVSVVCPGFTDTPLLDHANPGLPQTATGAGARRSATRTQGRLYSVDALAGDIMKGLARNRALIVAPASGRMAWRGVRLSPSLAVRAASLAIRRLGGA
>NC_013595.1|WP_012893267.1|7517100_7518090_+|diiron-oxygenase
MTPAPNTTADRESDQAVAEKRAYEAVIERLSKASVDKHWEPYADIPWDDEDFLVHQDDPRWELPGVDKLGGHPWYRAQTPEIRARIGLWRVATAMKIGLQFENLLKRGLLNYAYRLPNGSPEFRYVYHETIEEGHHGMMFQEFVNRTKFPIRGMPGPLSLLAQVTPWIPLISTELFFIFVLGGEDPIDHVQRKTLRDGQIRHPLEETIMRIHIAEEARHISFARHYLRRRVPRMPRHRRFTLGIVSPVVLGIMARIMLSPPGSMIKRFRIPEHVVKEVYTDNPETAQQIRDSVGKTRELCAELGMMNPVQRRVWKAMGIWAAPAGKAAR
>NC_013595.1|WP_169369425.1|7515993_7516878_-|EamA-family-transporter
MLLLSVSVAWGSAFPLMKDLIARMPVADLLAERYGIATLALFALRPRCLRGLPESTWLTGLLLGLLFGVGQTAQAVALHDLPSSVSGFTVGSYVVITPVLGLVLLGARISGRTWGAVALALAALTVFTLLSEAEGGAVSLPALAVTLLSAVLYAGHTLVLGNFAGARRDAYAVTVIQLGTIALMTGVLAAPDGLTLPRTTGDWALLGHLSIVACALGFLARSYGQLHVPPVPAAVILSAQPLWVTALAVVMYGEPLTWAVFLGGGLIALAMLLVVLPGGLFRTARRGTGPAPPR
>NC_013595.1|WP_012893265.1|7515434_7516037_+|TetR-family-transcriptional-regulator
MARGFGRLRRDDLLRTACDVIAAQGFGHTRTADIAQAAGVSQALLFYHFETKEKLFAQAFAYAAERDLEALTKLEDAGGSPLERLRGLLKLYSPTGRSKSWALWIDAWAESMRNADLEEMSRRMDLRWRQALRAIIDEGAAAGAFTCADPDGATWRIVSLIDGLSTQTTVHKRVLPRARMAEFIRTATAGELGLSLDVLS
>NC_013595.1|WP_012893264.1|7514081_7515425_+|HAMP-domain-containing-histidine-kinase
MVTRNSWSVRTRLTLIAITVAFLCGLLATTVLLLSLHDLADSFRTNEVASAAMEVIHLDEETSAPVTLPQGDAAGVQVVNSVGMVVAATPSLTGAPAVADFAPPAGSTRADRELCEIPEFPGRCMVVVALRIPRPGGDWLIYSVDDAVPWYVQPQVFAVLVGACLVLVALAGIGAHHMVTRALRPVSDISDHLAEITATDLGRRVPVPEAHDEVGKLAETINQTLDRLEGTVEQQRRFASDASHDLRSPLTAMRTQVEEALLYPDDTDWSAKATAMLASLDRLQALVSDLLMLARIDAGTPASREPVDLGELCGDELERRKRGVEVVRELKPGLVVEGDRLRLARLLTNLMDNAERHAVSQVTVSVTEEDGTAVLEVLDDGAGIAPEQREVVFHRFTRLDASRSRDAGGTGLGLSIAREIAQAHGGTLGLEDSPQGARFVLRLPLTR
>NC_013595.1|WP_012893263.1|7512728_7513910_-|acyl-CoA-dehydrogenase-family-protein
MNLEEYRRRARSWLEANAQRSRDEDDPGADGVAVAKAFMADLYDAGYSGISWPAEWGGQGLGQAEERAFAEEAKDFTLPTYVFSIGLGMCGPTLVDLGTPGQKARHLRPLLRGEEIWCQLFSEPGAGSDVAALQTRATETEDGWVVSGQKVWTSVAQHADWGLLLTRTDVDVPKHKGLSMFVVDMHAPGVTVRPLRDMTGRAHFNEIFFDDVHIPAENLVGRVNDGWSCAVTTLLHERLSISSGVGMGGQKDNPVAFETLRHTVDTGDPLVKDQLVELYIRSRALALFNQRLAQETKAGIFPGARGSAAKLLLAELSMFQADLATSLAGPEAVAYEDDGRLAGSIALAPALSLGGGTNEIMRNIIGDRVLNLPPEPRVDKNVPFKDLKTGTRQ
>NC_013595.1|WP_012893262.1|7511751_7512732_-|acyl-CoA/acyl-ACP-dehydrogenase
MNLVLTEEQRELRGTVRSFLAAASPLPEVRRAAESESGYDPAVYRRLNGELGLAGLIVPQEYGGAGAGYAELAIVLEETGAALLPGPFLATTLAAILLTELGDKELLPAIAAGTTVATVALDGDRALNGAEADVVLMVDGTRVRAVRGGGRTPLTTLDPTRRQARVEAAGGETVASSPEGMERVRDLFAVAVAAEQLGVLRASLDAIVAYSGIRVAFGRPIGSYQGVKHKLADMHCKLEQAESIVRNAAWAADEAPGELPLAAALAQAYVGRACFEVARDSLLLHGGIGFTWEHDAHLYYKRAKSDEVLLGPPRIHRTRLADLLEL
>NC_013595.1|WP_012893273.1|7526861_7528265_-|non-ribosomal-peptide-synthase/polyketide-synthase
MTTPDQRAALLSRLAELPPERREALLGRARDRDAGRTWPLSFGQERLWFLSRFDPADTTYHTPWCVRLRGPVDADGIAAALTRVAGRHHVLRTRFRLAGDRPVQVVAPAGPVAVERRDVTGDPAPAVVEFVNRPFDLEAGPPLRVALMRLAGEDFILCVVLHHIVVDGWSLDVLMRELAECYAAHREGREPLLAELPTQYTDVAAEDRRRAEHEDTAHLDHWTRTLAGAPVLDLPADHPRPARWTGRGGQESLLVPDEVITRLEGVARQQRCTLFMALLAAYQVTLGLAAGQEDLCVGVPVAGRNRVELEPLIGYFATTLALRADLSGDPTFRELLKRTRLSVFRGLQHAEVPFERILGALRLPRDLSRPPLLQAMFNLHNLPKGDLLRTEMADLAVEVYPMPPAGRTKAEISVDAWRGPEGLGGVLDYNSDLFSAGTARRLVRAFTDVVERAGTDPDLRLSDLRGV
>NC_013595.1|WP_012893274.1|7528261_7529698_-|hypothetical-protein
MTTALTRQGAAVVEFTGARGGEAPLTWGQQAIWRLTRWLDDGDPYFNMPWTLPVYGRRDLDAVLLALRGLVERHETLRTTCEETPAGPVQRVAREGRLTVEVFDAGEARPLAAAKELAADLASKGFDYATEPPIRCAVVTGGGRPRAVAFALSHLAVDGWALDILATDWKGLLAGDDLPEPAWQPLDQAAFEREGAGAARGERALRHWRAALERVPRSLFDFPRQPPEEQRFVRVGMESVALAAAAERLAARWSVSTASVLTTASAVLLAVLTGHREVVMQLIVANRHDPRTSAMAGTAVQDGIFVLDLPEGTFADAARAGHRQALTTYRHAHYDPFRMMALREEVGRERGGPVDLSAYFNDSRATGHWPNLPRTAREGDAAALAALTERTRTFFVGAWPEVDATVFFATGPATDTCRLHLLTDTACLPRSTAYTLLRGMETLLVRSVAEDVPLDAVAGLCGITPVERPAAVAGGGGR
>NC_013595.1|WP_012893275.1|7529694_7531428_-|non-ribosomal-peptide-synthase
MSVSLIDGWDRASLAQHGMWITERTGAGGRVYAMPLAVRFDGPLDVDAMLAACAAVVERHPVLAATLAEQDGHVRLVPGEVPPPIRFEDVSGPSGEVFGDVSAPPGGTSGEAPALSGGASGPSGGIEAELSRPFDLVTGPLARFTLFRLGPARHVLQIVAHHAVFDGMSKDIVLRDLAAAYGGSPLPPLPISYGEAARAEQDRVAAGLEGAAEFWRPRWHDDQDLLLPGATRPSLRAAPGGTVDLALGGETAGVAERLGLTRFEVVLAALHTLLHGYGNDRVAVAVDLSTRTEETRDHVGLFVNELPVVSTPQGTFAEFARTLREELRAVYRYREVPLARALGGISPRTALTPVSVSYRRRSGPDPVFPGLDASVDWTAFNGAVRNTLHLQVVESPDGLAARLQFNPEVLSRAACESVAGHLRTLLLGIAARPDAPITELPSPGREAAPAREAAPAGAPGTVPASASVDSGTAPASAAIASGAVADSAPDASPAAGAAAGAVEDPALLGEVGAIWCEVLGVDEIQPDDDLFDLGGHSLSITQIIARVRDRMGVELSFEVFIDTPTVAGVAEEIARSR
>NC_013595.1|WP_012893276.1|7531429_7532941_-|acyl--CoA-ligase
MTPAVVPVPRTVPEMLRLRAAQEPERAAVIVEGNGAMTFGEWERRSDALAHGLLDRGVRPGDRVGLIFGSWDWIDFSVAYCAAQKAGAVAVPLSDRLAPAEVRHMLAHCSASAVLYGRDLRPPAGDHWSAAPADLEGDAAGAVDVRVGPGDLAQILYTSGTTGLPKGVAASHANLVFGCETRPNRRRFGHSRHLLHAFPIGTNAGQTMLMNALDARPAMLTLGRFTPGRFARLIESYGAGTVFVVPAMAIEFLNAGLHERHDMSSVLLLGSAASALPPSVSVRLAAAFPSATITNYYTSTEAAPAQTIMIFDPARPGALGRPAFGGSLRIAGPGGDPLPAGETGEVWLRSPAVPRSYYRDERAGAEAFRDGWVRMGDLGHLDADGYLHLVDRESDVVKSGAFKVSTLQVEAALYEHADVAEAAVVGLPHPVLGTTLAAAVVPRSAGISGGDLRAFLTERLAGHELPERVLVVDALPRNQSGKVTKRELRRLFDAAATGQTEGT
>NC_013595.1|WP_043657321.1|7532937_7533153_-|acyl-carrier-protein
MISTACDGRLTSEEILASGTSLSALGVTSLALLRLIDAVEDEFDVTLDLGGGAPYLDSFPLLVGYVAARTS
>NC_013595.1|WP_012893278.1|7533323_7533503_-|MbtH-family-NRPS-accessory-protein
MSFLVVLNDEEQYSVWPGGRELPAGWRAEGFQGPREDCLAHIDQVWTDMRPLSVRQARA
>NC_013595.1|WP_012893279.1|7533499_7539130_-|non-ribosomal-peptide-synthetase/MFS-transporter
MRAIPFTTARERMPVPSRQHGGVVTHTSLSPAKQALLAQRLGGRVVAAAIPPRPPGTAPPLSPAQERLWFLEQYAPGTAAYTVAFAVRLEGEVEQEALTTALTEVTARHESLRTRLLTTEDGGPRLVVDPAPVAELRVTDDLAVVDQEMARPFDLARGPLIRLLLVRLGPLEHVLLLTMHHAVTDGWSCDIVMEELLTLHAAHRAGRQPLLPPVGVAYGDYAHWQRDRAYDREIGYWRRHLDGLPPLELPADLPRPAEQKWEGAARGLALDPGLGEEITALGTAHGATPYMTLLAAFQVLLGRYCGQDDFAVGSPVSGRDLPELERVVGVFVNSLPMRADLSGDPTFTELLARVRETALDAYAHQELPFDRLVNELAVERDVSRSPVFQVMFALQNYRSTPLRTPGLTMSAFPVETSASRFDLALYLFETPEGLRGNLTYSTALFRPDTIERMAACFENLLRSIVADPGARISELELLPDGERRRVLALGESAPAEPSGSGLLHEAVSAQARRTPDAVAVVAGGTSLTYAELERRANQLGHLLRRRGVGPDDRVAICLEQSAELAVAVLGVLKAGAAYLPLDPDHPADRLAYVLSDAGARAVVTAPELRDRLPGDLPAVFTEHLDEADPGPVDSGVTPGHLAYVIYTSGTTGRPKGVAVQHRQVTVYLDGARERLGVEPAGAFGLLQSLAFDFGVTVFYLCLTTGGALHLIPSRTAGPELAAYFRGHGIDYLKITPSHLAALLADATPAELLPRKLLILGGEAAPWGWAAELAAAGRCRVVNHYGPTEATVGVTTYAVGPGTGAPEAGGLSRPAPGAGPAPGAGPALGAGPALGAGPAPGSAAGPAPMAGAALPIPVAGAALPIGSPLPGARVHVLDANLRPVPIGVPGEIHLGGDRLARGYLGRPGLTADRFLPDPRGGPGARMYRTGDLGRWLPTGELEFLGRCDLQVKIRGYRVEPAEVESVLGDFPGVAHAVVELRGGRLVAYLVATVRAEAAEVRSWLADRLPDYMIPARYVWLDELPLKSHGKVDRSRLPEPGADVPAAGYVPPETAPERAVAAIWADVLEVERVGALDDFFDLGGHSLLAMRVIARLRKEVPGRTLTVLELFKHRTVRDLARLLEAEDAGPRDLLHRLTPVRAATSTMVCVPFGGGSAVVYQPLADALPAGWALYSVAVPGHELGERARPFDEVARDCAEEILAGIEGPLVLYGHCGLGVMLVAEIARRLEAAGRVIDAIYLGGVFPFARPGRGLGWLGTLMDRMTSDQGRINALAAAGLDVEEFERDQLKLIIENRRHGTRTAERYFTRLFEGEGDPLRAPVIAVVGERDPATEFYQERYREWRRLSETVACVVLDEAGHFFVKYRAEELAAILTGTHRAVASGETAPLERTEESTWWLHGLSGQATRPPGAGEGGSAASGAGERGAPQASMRRFLLISVGQLVSITGSALTEFAIPIWIYLNTGSLARFALFAVLGLVPGMLVAPLAGAIVDRYDRRRVMLCGDVAAGGTQLALGVLLWTGNLEIWHIYPLLACLSVALTFQRFAYGSAIPQIVPKRFLGHANGVVQMATGTAQLVVPLIATGLMATIGLGGILVIDVASYAVATIVLLFVRFPAGMPWRRREGVVTEMMNGIRHSWGNPGFRGMLVFFAVLNVFLSPLFLMISPLVLSFATLDDVGRIAFAGGLGVFLGGLLMTAWGGPRRRRLYGVLLATLALAVFCVVTGFRQNLPLIAAGAFGMSFCLTLLNGVYATIIQVKVPQRFHGRVIALNTLVAWSTLPIGFGLVAPYGSAVFEPLLAPDGPLASTVGALIGTGEGRGIGFMYACFGLAIAAIALVAMRVRVLAWFDTDVPDALPDDLVGFEALRSRTRKKEEEEAQR
>NC_013595.1|WP_012893280.1|7539515_7540508_+|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha
MSYRYPAAERVPPVADARSAHVIVTVPTPAGLRNAPSPPADEDLELLLLIRHFELALLRLFEAGELSGTTHTCLGQEYIPVALKPLLQEDDHVFSNHRGHGHFLARHAEPHGLLAEIMGREGALCAGVGGSQHIYHRRFLSTGVQGESLPVAVGVALKLKGSGALACAYVGDGTWGEGSVYEALNMAQLWRVPLLVVVENNGIAQSTPTAAQMSGDIAARAAAFDVLHHRMTSTEVDEIRAELAPLLTVVRGDSRPLVAEFVTHRLGPHSKGDDTRPPEEIARARDHDWYARYARMFPDRFDRLDRERRELVERIAAEVAARPPSVWERR
>NC_013595.1|WP_012893281.1|7540504_7541491_+|alpha-ketoacid-dehydrogenase-subunit-beta
MTRVSEHLNQALHDLMEADPRVHLLGEDVSDPYGGAFKVTRGLSTRFGDRVRSTPLSEGALAGVGAGLALAGDRAVVEIMFADFAALAFDQLVNFAAKSTSMYGRPVPIPLVVRCPSGGNRGYGPTHSQSPQKHFIGVPGLALFEMTPFHDAGELFARMFALGQPCLFFEDKVLYTRRMYEDGVVDDLFRYELDGDVARVFLDGVTEPDCTLIAHGGMAHRALSAMRELLLEEDLACELLVPARLHPLPGLPGLERARHVCVVEDGTEGGTWGAEVARLLYPRLWSTLRRPIGLISAADSVIPAAPHLEREVLVQPGRIRHTIVEALS
>NC_013595.1|WP_012893282.1|7541487_7542678_+|2-oxo-acid-dehydrogenase-subunit-E2
MIEIRVPKLNNNDTVYLLVEWAAGDGQAVRAGEPLAVLETSKAAEELTAEEDGTLLCLLEAGAECAPGQVIARLLAEGEEAGAAAGPPPQPVPAGHGDPEAIVVTAPARLMMDERGISMEQVRTLGRKVIRRADLELLGASRTAPQDSGPPAVPMDAGPPSAPVDADDPGLIELSRTQRRVAEVVERSHRDIPAAFTVMRVDVTDALLFARRETKRLRVLVGVPELLVEAAGRLLDRFPLFFATPVDGRRARRAATAEVGVTVDVGRGMFVPVVRDAGGRPLGEIARELTRFRRTALNGAFREQDLRGGNIMVTLHTDAAVVMAAPVVFPGQVCALSLTAPRPEVVETRDGGFTVRKVIMLGLAYDHRFVNGRESAEFLGALRSALESPGDGTSER

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Crispr_ID: NC_013595_41

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_41

7609024-7609121

Orphan

Consensus_repeat	Method
AGGTCAAAAGCGCAGCGAGAGGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_41

>merge|NC_013595|41|7609024-7609121|CRISPRCasFinder
AGGTCAAAAGCGCAGCGAGAGGTGGGTGGGGTGGCCGAGGACCCGCTCTTTCGTGCGGCGCCATACGGGGTCGCAGGTCAAAAGCACAGCGAGAGGTG

>NC_013595|41|39|7609024-7609121|CRISPRCasFinder
AGGTCAAAAGCGCAGCGAGAGGTG	GGTGGGGTGGCCGAGGACCCGCTCTTTCGTGCGGCGCCATACGGGGTCGC
AGGTCAAAAGCACAGCGAGAGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012893334.1\|7603788_7604838_-\|WD40-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|225201
NC_013595.1\|WP_012893336.1\|7607019_7607751_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275426
NC_013595.1\|WP_012893343.1\|7614635_7615991_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NC_013595.1\|WP_012893332.1\|7601726_7602707_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_013595.1\|WP_012893333.1\|7603018_7603792_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893342.1\|7613625_7614639_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NC_013595.1\|WP_012893331.1\|7598298_7601676_+\|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|226418
NC_013595.1\|WP_012893337.1\|7607915_7608722_+\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|252734
NC_013595.1\|WP_012893344.1\|7616366_7616639_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NC_013595.1\|WP_012893335.1\|7605056_7606694_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_013595.1\|WP_174435304.1\|7616993_7617386_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_081453485.1\|7611877_7613173_-\|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|237999
NC_013595.1\|WP_012893340.1\|7610667_7611708_-\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|173833
NC_013595.1\|WP_012893347.1\|7618646_7619198_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_013595.1\|WP_012893339.1\|7609295_7610444_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173840
NC_013595.1\|WP_012893348.1\|7619397_7621572_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_013595.1\|WP_043653436.1\|7617672_7618536_+\|NAD(+)/NADH-kinase	unknown	unknown	gnl\|CDD\|223139
NC_013595.1\|WP_012893329.1\|7596359_7596911_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893330.1\|7597085_7598126_-\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176190
NC_013595.1\|WP_148269754.1\|7595356_7596328_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012893334.1\|7603788_7604838_-\|WD40-repeat-domain-containing-protein	gnl\|CDD\|225201	COG2319, COG2319, FOG: WD40 repeat [General function prediction only].	3.15645e-09
NC_013595.1\|WP_012893336.1\|7607019_7607751_+\|hypothetical-protein	gnl\|CDD\|275426	cd13391, PH_PRG, PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain. PRG (also called RhoGEF11) belongs to regulator of G-protein signaling (RGS) domain-containing RhoGEFs that are RhoA-selective and directly activated by the Galpha12/13 family of heterotrimeric G proteins. RhoGEFs activate Rho GTPases regulating cytoskeletal structure, gene transcription, and cell migration. PRG contains an N-terminal PDZ domain, a regulators of G-protein signaling-like (RGSL) domain, a linker region, and a C-terminal Dbl-homology (DH) and pleckstrin-homology (PH) domains which bind and catalyze the exchange of GDP for GTP on RhoA. As is the case in p115-RhoGEF, it is thought that the PRG activated by relieving autoinhibition caused by the linker region. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.	0.00866567
NC_013595.1\|WP_012893343.1\|7614635_7615991_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.01923e-109
NC_013595.1\|WP_012893332.1\|7601726_7602707_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	5.24393e-90
NC_013595.1\|WP_012893348.1\|7619397_7621572_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	7.64713e-108
NC_013595.1\|WP_012893331.1\|7598298_7601676_+\|winged-helix-turn-helix-domain-containing-protein	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	1.3594e-64
NC_013595.1\|WP_012893337.1\|7607915_7608722_+\|SAM-dependent-methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	6.46647e-112
NC_013595.1\|WP_012893344.1\|7616366_7616639_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	0.000749049
NC_013595.1\|WP_012893335.1\|7605056_7606694_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	3.58915e-132
NC_013595.1\|WP_012893340.1\|7610667_7611708_-\|polyprenyl-synthetase-family-protein	gnl\|CDD\|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	5.96461e-88
NC_013595.1\|WP_012893347.1\|7618646_7619198_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.90332e-11
NC_013595.1\|WP_081453485.1\|7611877_7613173_-\|cyclic-nucleotide-binding-domain-containing-protein	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	1.32671e-16
NC_013595.1\|WP_043653436.1\|7617672_7618536_+\|NAD(+)/NADH-kinase	gnl\|CDD\|223139	COG0061, nadF, NAD kinase [Coenzyme metabolism].	1.08991e-62
NC_013595.1\|WP_012893342.1\|7613625_7614639_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.3558e-73
NC_013595.1\|WP_012893330.1\|7597085_7598126_-\|NADP-dependent-oxidoreductase	gnl\|CDD\|176190	cd05288, PGDH, Prostaglandin dehydrogenases. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.	2.13058e-157
NC_013595.1\|WP_012893339.1\|7609295_7610444_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173840	cd01151, GCD, Glutaryl-CoA dehydrogenase. Glutaryl-CoA dehydrogenase (GCD). GCD is an acyl-CoA dehydrogenase, which catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the catabolism of lysine, hydroxylysine, and tryptophan. It uses electron transfer flavoprotein (ETF) as an electron acceptor. GCD is a homotetramer. GCD deficiency leads to a severe neurological disorder in humans.	7.59315e-145

>NC_013595.1|WP_012893337.1|7607915_7608722_+|SAM-dependent-methyltransferase
MAEEEWVRRGIDVNTPSVARLYDYYLGGKDNFAADRAAAEEILSAVPELRMAARENRAFLGRAVRFMAEAGIEQFLDIGTGLPTRGNVHEVAHQIAPDARVAYVDNDPIVLVHARALLRGSRDEVLVASGDLRQPEEILKSPEIHDHLDFSRPIAVLLVAVMHFITESDDPRRIIATLRDALPSGSYLVLSHGTRDSRAAAVARGTKVYERANSPLVLRSRQEILELFDGFELVDPGLVWLPRWRPEGYQRHDDPERTLIMCGVGRKA
>NC_013595.1|WP_012893336.1|7607019_7607751_+|hypothetical-protein
MKRIAVGLLSAAVGGSLLLSAGTASAERTALSVRIDSVNPNPVVVQDGEDTRVTIEVRTTEATRVELRLKPVSDEFRALDVREPRIIHEGDLWRFSTSFDEDDFEGRWLAIAEAYDKDGKKVTDQVNFSVKHEEQEKADTRLTGFRADPEAVRKGRWVYFTGRLQVSRGHEWRGVRDEEVEIYFRPRGSSAWKWVTSADTGWKGSFRAKARASKSGEYRAVFDGDDRLEDSTSRSDRIRVWRR
>NC_013595.1|WP_012893335.1|7605056_7606694_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSATIVAKDLAAGHGDRALFSGLDLVVAPGDVIGLVGMNGAGKSTLMRIMAGLLPPEHGAVRLSPPSAAVGYLPQERERRADETVAAFLARRTGVADAQRELDAATEGLVEGRPGADDAYAAGLEKWLALGGADLEDRAEEVVAELGLAVDLDRPMTALSGGQAARAGMASLLLSRYDVFLLDEPTNDLDLEGLERLERFVVGLRAGTVLVSHDREFLARTANRVVELDLVQQRIGIYGGGYEAYLAEREVARQHARDEYEEYAGTVASLKQRAGMQRAWMEKGVKNARRKASDNDKVGRNFRTEATEKQAAKARQTERMIERLEEVEEPRKEWELRMEIAVAPRAGAVVATLRGAVVRRGGFTLGPADLQIGWAERVAITGANGSGKSTLLAALLGRLPLEEGNASLGSGVVVGEVDQARGLFLGGEPLLDAFGAAVPDMAPADVRTLLAKFGLRAAHVLRPAATLSPGERTRAALALLQARGVNLLVLDEPTNHLDLAAIEQLESALVSYPGTLLLVTHDRRMLDAVHTTRHIHVDAGRISEV
>NC_013595.1|WP_012893334.1|7603788_7604838_-|WD40-repeat-domain-containing-protein
MSVRQLGAPEDLETPRPLPARSPVPERITAIAATADLSRVAIATATPWFREFSEVLLLAEGTVVRLSVPGRRRVLDLVFDPDGSALTAMESGNSIYRWSFNAPGEPWTRAMTGGGGGDGPDLAQAAASGDGRFFATSNAFSRNVVVRDAATRRVVHDIENIFEGLAHQDRIQGEGTVALNADGSRLAFSTARRWSSKEGVVVQEIGSRACTEYRTGIPWVNGLAFGPDGAALAVVGARPDETVATVVDLDDPAAGPEPMVLPTGERVDRINLRPVWCGAEPLVPIVDQRRVTVWNLATASARLSVDAPGPRIAAALTPDGRTLVIASPDDGVQAHSLPFSPPDEEDPLR
>NC_013595.1|WP_012893333.1|7603018_7603792_-|hypothetical-protein
MSSLDGLLNARPTKEVWQEVCLRLAELDEEELAAVAPRVLSWPAQQRPMPDDDVPAEQKAFGPVALDARGRLLAHTAPDGRVVIREADGGAVLAAAQTGLTDVNALAFAPDGAALFAVGGAVEGAAVRGAQAGPAARMLNLDPAPDHPSLTAGALVRSAELPGELDAASPFAATSTRAVWADRGPFAFVASDHGSVLFDSVGRTLWAHPSGQIVSFTPDGQAMVTVGESIDAWFLAGLAVPERTGPGAADRTAGAPR
>NC_013595.1|WP_012893332.1|7601726_7602707_-|LacI-family-DNA-binding-transcriptional-regulator
MTRRLAEVAKKVGMSEATVSRVLNGKPGVSEATREAVLTALDVLGYERPTQLRGDRARLVGLVLPELQNPIFPAFAEVVGGALAQQGFTSVLCTRTLGGVSEAEYVDLLLQQQVSGVVFAGGLFAQADASHSHYELLLERRLPTVLVNAAVEHLAFPQVSCDDVAAAEMALGHLRSLGHERIGMVLGPPDHVPSRRKLQAAGLAPEFVEHTMFSLEGGHAAATRLIRRGVTGVICASDVMALGAIRAARRAGLSVPDDISVIGYDDSALMNCTDPPLTTLRQPIDAMGRAVVDLLAAQIDKALVPADELLFEPELVVRASTGPVKR
>NC_013595.1|WP_012893331.1|7598298_7601676_+|winged-helix-turn-helix-domain-containing-protein
MRFGVLGPLAVWTTDGRPVRVPELKVRALLADLLVHQGRPVPADRLADDLWGEDLPGNPANTLQTKVSQLRRALEQAEPGGRGLVAYLPAGYLLRIEADAVDARRFADLVVRARESGDPRARAALLSDALALWRGPAFADFGDEGFTRAAITRLEEQRLTVLEEQAEVRLELGEHGLLADELGDLVARHPLRERLRAAHVRALYRAGRRKEALDSYGELREQLAEELGLDPGPELTALHQAILEQDPALSAIPAPATSAARPRTNLPAPLTDLIGRDGAVAQLRALLESARLVTLTGPGGVGKTRLALETAAQLTGAFPDGVWLVELAGRRPAGGPDTRPAPAEVGETAEVGAVAETVAAVREVAETVAAVLGIRDGTTAGSRPGVRPAGLTDRLADALRPQRLLLVLDNCEHVVEPVAELAELLLRRAPGLRILATSQEPLAVSGEVLQAVAPLEFPGPAAGTELSDLRRSSAVRLFVARASAAAPGFVLDADNAPAVAAICRRLDGLPLALELAATRIRALGARGLAERLDDRFRLLATGKRGAPARQQTLRAMIDWSWELLTEPERVVLRRLAVHSDGCTLEAAEAVCPGEDLDTADVLDLLIRLVDRSLVATVNGTDGPRYRLLESVAAYCLERLHAAGETDRVRRRHDVYYTELAERAEPHLYGPGQRLWLQRLDAETSDVRSALQGAARRGEADLALRLVNAAAWYWFLRGRHREGHRLLTTALAVDGPVSAAALARATTWQAGFAMLAGDGTDLVRQSRTALKTYDGVDDPEHHARAEWFLGLAHLHFGDVSTGGDLAGRALARFRALDDRWGVAAALGSQARQAMFRGDFPAAGRSGSESAALFGELGDRWGRLQATDTLGYLAEVTGDHGRAARLHRDGLRVAEELQLWTDVSYRLSGLGRIALLTGDFAQAGELHERAMRLAAEQSNKFAEEFAEVGLGLGARRQGELETAETHLRNSLDWNRRLEADYGVPFYGVTLLLAELGFIAEQRGDAGQARSLHLEGLAAAREIGDPRAIALALEGLAGAQALAGDHGHAARLLGTATAVRASVGAPLPPAERGDVDRITSRARDALGEEAFAARFAEGTGLDHDAHLRYLTPPGPSALDPVPPRVLSV
>NC_013595.1|WP_012893330.1|7597085_7598126_-|NADP-dependent-oxidoreductase
MSSNVTPDKQIIGREIRLASRPAGEPGPENFELVRTEVPQPGEGQILVRNTWMSVDPYMRGRMDDAESYIPPFRLGAALEGGAVGEVVVSRSEAVAVGATVSHFLGWREYAVMDASAATVVDTAAVPAQAYLGALGTTGLTAYAALTEVAPVRRGDVVFVSGAAGAVGSVAGQLARKLGAAKVIGSAGGPAKAEKLVTGFGFDAAIDYRAGSIAAQLAEAAPEGIDVYLDNVGGDHLEAAIGAIRHAGRIALVGAISAYNATAPVPGPDNLYRAAYKEATLRGMLVTSYLHLFPEYIERAAGWLADGTLHTEETVAEGIGQAPAAFLGVLRGANVGKMLVRLDGIG
>NC_013595.1|WP_012893329.1|7596359_7596911_-|hypothetical-protein
MRKRSMTLTSAGAGVLMFLLAAPAVAAPTDDTPITFEVSAGSLDVSAPAGPVDLGNAPPGGEITGQLGPVSVSDTRGGATSDWTASVYATDFTVAALTIPFSALEYWSGAGTAPSGGGTFTPGQLTEDDRVTLTGTAGTAVTAFSHSGGTGGSTVTWNPTLVISIPLTAQTGTYNGTVTHQVA
>NC_013595.1|WP_148269754.1|7595356_7596328_-|hypothetical-protein
MAALCSGAAGPPAGASGQAVEDTHGKIGIRLLEAPVSRRDDPRARSYIVDHLSPGTTIRRRLEISNTSGDAQHIDLYPAGADIVRNRFAMARGRTPNELTGWVSLDRSSLDLPPGGRGTARVAIEVPPAASRGERYGVVWAQAVAEADAAHPVRVVSRVGIRLYLDIGRGGEPPSDFRIEELTPVRAPDGRPQLAALVHNTGARALDMSGSLSLSDGPGGLSAGPFAADLGVTLAPGAAAPVTVTLDRRIPDGPWKVELTLMSGMVKRTVSATVTFPRAGAGTPVPPDSGLLSLFGVLGGLAALLVAVAVLAVRLRRRRAAAG
>NC_013595.1|WP_012893339.1|7609295_7610444_+|acyl-CoA-dehydrogenase-family-protein
MTGDFYDYFELLDEDEKEIVLRVREFMAREVAPIADESWTNARFPHQLIPEFAKLDIAGLPYRGARSLLTGFLVLEMNRVDPSMGTFFGVHNGLAMGSIDRLGSDEQRERWLPPMAAMEKIGAFALTEPEGGSDVAAGLRTTARREGDVWVLNGAKRWIGNATFADLVVVWAKDEADGQVKGFVVEKGTPGFSATKIENKIALRTVQNADITLTNCLVREENRLRDANGFRDTAAILRQTRGGVAWQAVGCMMGAYELALEYAKDREQFGRPIAGFQLVQDLLVRMLGNVTCSLGMVVRLAQLQDAGVYKDEHSAMAKAFCTVRMREAVGWGREIMGGNGIVLDYGMGRFVADSEAIYSYEGTREINSLIVGRAITGVGAFV
>NC_013595.1|WP_012893340.1|7610667_7611708_-|polyprenyl-synthetase-family-protein
MTAVEVTAEGRSAREVLAWSRDLVESALRPAADTLPPSMRRIAGYHFGWWDEHGRPAGADGGKAIRPALVLLAAEVVGGGAAAALPAAVAVELAHNFSLLHDDVMDGDRTRRHRPTAWTVFGVSPAILAGDALLTLAFDVLAAGGHPATPRAARIFSAAIQELLEGQHTDVAFERRQDVELAECLSMAAGKTGALLGCACALGALFGGGSLAQVEHLHAFGRDLGLAFQFVDDLLGIWGDPEVTGKPVYSDLRSRKKSLPVVAALSSATPAGRELAGLYHGEHPLSDADLVHAAGLVDAGGGRTWSQAQADELLTRALGHLRSAGTVPGSVAELGALARLVTRRDH
>NC_013595.1|WP_081453485.1|7611877_7613173_-|cyclic-nucleotide-binding-domain-containing-protein
MQEISSRWLLRMLPWVQVSGGTYRVNRRLSYTIGDGRVSFTTVGSQVKVVPAELGELPTLRHFDDPEVLEALGERFAQREFSPGEVLVEAGRPADEVVLIAHGKLNKVGNGPYGDQVVLGVLAGGDHFGDETLAGPQGDWEFTVKAVTAGTAMILPRQAFQELTDQSESLQAHLRRVQAGPKGPQNKYGEAAIETAAGHAGETDLPGTFVDYELAPREYELSVAQTVLRVHSRVADLYNDPMDQIEQQLRLTIEALRERQEHELVNNREFGLLHNADLKQRIHTRTGPPTPDDLDELLSRRRNTQFILAHPYAIAAFGRECNRRGLYPLGIDVGGNTVPAWRGVPIFSCNKIPITGTRTTSILAMRTGEDNQGVVGLHQTGIPDEYQPSLSVRFMGISEKAIISYLVSAYYSAAVLVPDALGILEDVELGH
>NC_013595.1|WP_012893342.1|7613625_7614639_-|HlyC/CorC-family-transporter
MNLPIGLVLTIALLAGNGFFVAAEFALVAAKRHRLEKAAARGDRAAAAAVKGIKELSLMLAGAQLGITLCSLGLGVVSEPLIAGSLAPLFADLGLPGAAAHAVAFVIALGIVTFLHMVFGEMAPKSWAIAHPERSATVLALPFRAFTMAVRPVLKTLNGVSDLLLRMAGVRPRGETATPRTPEQLQHLVEESRRLGLIDTDDHVVLTQALNAPNAPIARLVTPREAIVGVPAGAEPQDVIDTSARTGRTRLVVWDGDRPAGVVHVRDAYLARRRGLRARAGDLLHRMPELAATSSIADAVARLRAAHSQFALVRAADGTLAGLVSLDDLLTTLLAPA
>NC_013595.1|WP_012893343.1|7614635_7615991_-|HlyC/CorC-family-transporter
MSIALGLLAVLLLTLATGYFVAQEFAYVTADRLALSQRAAAGDRKAARAVKVMGRLSFMLSGAQLGITVTALVVGFIAKPALAELVAPALRAAAVPEAAVGGIALLLGLIVATVVQMVLGELAPKNLALARPEPLARALASSTLVYMTVAGPIIRLFDGAANRLVRAVGIEPVEELRHGATLEELGHIIGESEAYGHLPGDQADLLERALAFSDHTAEEVMVPRVDVVTVSGSVRIPDLDELIARHGHTHYPVLGDSLDDVIGIAGLREVVPIPVDKAARTRVADIAREALVVPFSASLPDLVAQMRARHEEVACVVDEHGGLAGLVTWEDVAEELVGEIADENDLDMPAVERRGDGWEAEAGLRIDELALATGIELPDEDDYDTLGGLVLQRLGRFAVPGDVVTVEPVPSMDAGAPTHVEIEVLTIDRHVPGRVRLRPVRRAGESRQGAS
>NC_013595.1|WP_012893344.1|7616366_7616639_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MTITGIITAIVIGAIIGALGRLVVPGKQGIPIWLTIVIGIVAALIGTAIAGALGVGATKGIDWIELIIQVVLAAVGVILAVSMYSRRGVR
>NC_013595.1|WP_174435304.1|7616993_7617386_+|hypothetical-protein
MDERPAGSPPPDIDDTTVEALGRLSEALETTERARGHLYSFHQLTGHADLQLDRVVELLRAAGHPDLADVVADELIGRNVLPDRWTFQIMEEYDDGYYRFFAGLEKRIRDQLAGGRRHLYEARMKRERQS
>NC_013595.1|WP_043653436.1|7617672_7618536_+|NAD(+)/NADH-kinase
MGMVETVGLVLHPQRDSKVAIDTIVEWARAHGVTVLGLPEEVGRIDCSAVPVDTDTLVDRADLLVSLGGDGTMLRTMRLIAGRPTPILGVNLGKLGFLAEIDVEDLSSALSAIDSHEYTVEPRMAVRATFREGETVTAFNDVALVRTPGDGLSAVAISVEGHPFVRYAADAVIVATSTGSTAYSFSAGGPIVSPTVEGFLVVPAAAHSAFNRALVLSADEEVSLEVLSTSGRLAMEVDGAIGAHLSPGDRLTVTAVRAAAWVVRLGTTSFYERARRKLRVNGSAEVD
>NC_013595.1|WP_012893347.1|7618646_7619198_+|TetR/AcrR-family-transcriptional-regulator
MSRGTRSGTREEILDAAARLFAATGFKGTSLQDIAGEVGCSKAALLYHFDGKDAILTELLAPPLEALATLDARLAGLGDDAVQLAAVEGYVDLVMRFRREVTVLYDDMPALLQRPAFAGVQEMSDRLLDALAARSPDPAARITALMVLGSVPVVCMKPTEIGDDELRSILTRSAARTLDLRRA
>NC_013595.1|WP_012893348.1|7619397_7621572_+|MMPL-family-transporter
MATLLYRLGRASFRRRRLVLALWLAVLAALGVATAAFIGPTASNFTMPGTESQRALDALAKHFPEAGGATGTIVVAAPEGKQLTTPQARQAIGALTKEASGLPGVVAAVDPFQIGAVSPDGRHALVQVQFAAVNDRVTDGQRAAYAKVGAGAEAAGLRVEHGGEVMTSEPEIGSTEALGVAVAAVVLVITFGSLVAAGMTMLTALIGVGVGMAGLFALSSAIELTSTAPVLALMLGLAVGIDYSLFITSRHRQNLLDGLEPEEAAARAVGTAGSAVVFAGATVVIALAGLAVVNIPFLTVMGLAASGTVAVAVLVAITLQPALLGFAGHRILPRKHRTARQAVPGERGGFGFRWAYIVTRWRVLVILAGVLGLGGLAVPAAEMRLALPDAGTAQAGSPAREAYDLISAGFGPGFNGRLAAVVSGGSAEATGRAAKEATALIQATKGVIAVTPPQPNASGTTVLLAVIPATGPTDAATETLVHDIREKVRGIDGAQVSLTGMTAIGIDVSEKLSDALPVYLLLVVGLSVLLLMLVFRSVLVPVKAALGFLLTVGATFGITVAVFQQGWLAGLLGVDTPGPLVSFLPILLIGILFGLAMDYQVFLVSRMREDFVHGDTAQQATISGTGHGARVVTAAALIMISVFSGFVLLDDPIIKSMGFALAVGVAIDAFVVRMTIVPAVMSLLGDSAWWLPRPLARVLPNVDIEGEQLRAHLDHEATEVPARV

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Crispr_ID: NC_013595_42

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_42

7643275-7643363

Orphan

Consensus_repeat	Method
GGACCGGGTTCGACCGCGGCCGGATGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_42

>merge|NC_013595|42|7643275-7643363|CRISPRCasFinder
GGACCGGGTTCGACCGCGGCCGGATGCGGAGCCTGCGGTGGACCGGGTGCCGAACCTGCGATGGACCGGGTTCGACCGCGGACCGGATG

>NC_013595|42|40|7643275-7643363|CRISPRCasFinder
GGACCGGGTTCGACCGCGGCCGGATGC	GGAGCCTGCGGTGGACCGGGTGCCGAACCTGCGAT
GGACCGGGTTCGACCGCGGACCGGATG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_043657343.1\|7634768_7636394_+\|DUF3459-domain-containing-protein	unknown	unknown	gnl\|CDD\|200471
NC_013595.1\|WP_043653446.1\|7643648_7644356_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_013595.1\|WP_012893361.1\|7639242_7640301_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012893355.1\|7629933_7631913_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274350
NC_013595.1\|WP_012893369.1\|7646744_7648424_-\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|227136
NC_013595.1\|WP_012893362.1\|7640746_7641130_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893371.1\|7650046_7650334_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893363.1\|7641426_7641990_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_169369431.1\|7652505_7652928_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_013595.1\|WP_012893356.1\|7631839_7632667_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893370.1\|7648497_7649541_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187539
NC_013595.1\|WP_012893357.1\|7633032_7634289_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_174435271.1\|7645187_7645571_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043653441.1\|7638943_7639240_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893360.1\|7636505_7638392_-\|DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|273594
NC_013595.1\|WP_012893364.1\|7642204_7643242_+\|fibronectin-type-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|238871
NC_013595.1\|WP_012893373.1\|7651571_7652027_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_013595.1\|WP_012893372.1\|7650449_7651436_-\|response-regulator-receiver-protein	unknown	unknown	gnl\|CDD\|197715
NC_013595.1\|WP_169369429.1\|7645587_7645752_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_169369427.1\|7644526_7645204_-\|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl\|CDD\|225002

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_043657343.1\|7634768_7636394_+\|DUF3459-domain-containing-protein	gnl\|CDD\|200471	cd11332, AmyAc_OligoGlu_TS, Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins. Oligo-1,6-glucosidase (EC 3.2.1.10) hydrolyzes the alpha-1,6-glucosidic linkage of isomaltooligosaccharides, pannose, and dextran. Unlike alpha-1,4-glucosidases (EC 3.2.1.20), it fails to hydrolyze the alpha-1,4-glucosidic bonds of maltosaccharides. Trehalose synthase (EC 5.4.99.16) catalyzes the isomerization of maltose to produce trehalulose. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NC_013595.1\|WP_043653446.1\|7643648_7644356_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	9.15441e-10
NC_013595.1\|WP_012893361.1\|7639242_7640301_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.74843e-85
NC_013595.1\|WP_012893355.1\|7629933_7631913_+\|hypothetical-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	1.0336e-06
NC_013595.1\|WP_012893369.1\|7646744_7648424_-\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NC_013595.1\|WP_169369431.1\|7652505_7652928_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.81578e-19
NC_013595.1\|WP_012893370.1\|7648497_7649541_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187539	cd05228, AR_FR_like_1_SDR_e, uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs. This subgroup contains proteins of unknown function related to aldehyde reductase and flavonoid reductase of the extended SDR-type. Aldehyde reductase I (aka carbonyl reductase) is an NADP-binding SDR; it has an NADP-binding motif consensus that is slightly different from the canonical SDR form and lacks the Asn of the extended SDR active site tetrad. Aldehyde reductase I catalyzes the NADP-dependent reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. The related flavonoid reductases act in the NADP-dependent reduction of flavonoids, ketone-containing plant secondary metabolites. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.37003e-55
NC_013595.1\|WP_169369427.1\|7644526_7645204_-\|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl\|CDD\|225002	COG2091, Sfp, Phosphopantetheinyl transferase [Coenzyme metabolism].	5.85715e-33
NC_013595.1\|WP_012893360.1\|7636505_7638392_-\|DNA-helicase-RecQ	gnl\|CDD\|273594	TIGR01389, recQ, ATP-dependent DNA helicase RecQ. The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_013595.1\|WP_012893364.1\|7642204_7643242_+\|fibronectin-type-III-domain-containing-protein	gnl\|CDD\|238871	cd01833, XynB_like, SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	6.88313e-32
NC_013595.1\|WP_012893373.1\|7651571_7652027_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	6.59855e-21
NC_013595.1\|WP_012893372.1\|7650449_7651436_-\|response-regulator-receiver-protein	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	9.35283e-06

>NC_013595.1|WP_012893364.1|7642204_7643242_+|fibronectin-type-III-domain-containing-protein
MIVGDSISHGLEGDYTWRYRLSQNFGKHGFPVRFAGPETGTSVLPASQPGDYPARTADPIHNGRYRPGIDFGDSRHYARWGRLLHEAKDNIRDAVAAHGADHLMVELGFNDLAWGVSGPGRLTADLGTFVQRARDANPDVQFLVANVVHRTPLDSGPGLADVITAYNEGLPSTLAAMSTARSAVVPVDLAGVYDPGGDTYDGLHPNSVGEFKIAKAFADAFSAVFGRGRIDFLDPVPRTADPLAISPPAGIAATPHDSSISVSWPHVFGASGYWLYWRDVTAGQGFQRSPLPILADSLEVPAERGHTYEFMVSGARGHQETPTTRIAAVLAGQPALSLAGGLAGR
>NC_013595.1|WP_012893363.1|7641426_7641990_+|hypothetical-protein
MATETAPARHSHTWISALNSRYHKAALGLYLVIVIAHWAEHVSQAIQLYVLGWPLPEARGVLGVPFPWLVKSEWMHYGYALLMLIGLILLRKGFTGRSRTWWNVSLGIQVWHHFEHLLLLLQALTGSNLLGRPVPTSIIQLIVPRVELHLFYNAIVFLPMVVAMVLHRRPRGSERAAMRCGCAPAHA
>NC_013595.1|WP_012893362.1|7640746_7641130_+|hypothetical-protein
MGSLLGPCLYVVAIFVLGLGPIVLVFAALFAMAVLYVVALMTPGGSPLTATPGGRVLWAGAILILGVIGWIAGASALGKLGLSTTDPLWWSLLSAVPFALAAALCAGGWTSLVSLVLTTALILTGCS
>NC_013595.1|WP_012893361.1|7639242_7640301_-|serine/threonine-protein-kinase
MIVEPSHIGPYRLEGLLGEGGQGAVYLGVDPSGGRVAIKLLHARLAHDAGNRRRFLREVEAARRVGPFGTAQILDVDVQGSQPYIVSEYIPGESLQQLIAREGPRAAGGTRRLMLATAAALKAIHEAGIVHRDFKPSNVLLGPDGPRVIDFGISLALEGTTMQSSAVVGTPPYMSPEQLRGAAVGPESDVFSWAVTMVFAATGRPAFGQDSMPAVFNRILNHEPDLAGVPPELRGLLGACLAKEPHHRPDAGGLVRLIVGEEAAPPMPQAVTRVREPDPAGERPWGLAFAAQIITTLAVATVFLTVAELDSRQWPDIPVPGTAGLPFWPATLTGLAAGGAIALVLRLLTRRS
>NC_013595.1|WP_043653441.1|7638943_7639240_-|hypothetical-protein
MDLALMLAVLFAAAVVAVTARIIAVRGRTFLARHRLLLAVTLLPLQPVLGVGIGVLLITQWDHVDGNGVVFGVIAYLAGLIAFGIVTGVQELRRAWRR
>NC_013595.1|WP_012893360.1|7636505_7638392_-|DNA-helicase-RecQ
MVSPVSGPEVSDALRVLHRVFGYDSFREGQQEIIDHVVAGGDALVLMPTGGGKSLCYQIPALVRDGVGVVVSPLIALMQDQVDALTALGVRAGFLNSTQDHDERRQVESAFLAGELDLLYLAPERLRVDSTLRLLDRGTISLFAIDEAHCVAQWGHDFRPDYLALSALHERWPDVPRIALTATATEATHAEIASRLNLEEARHFVSSFDRPNIQYRIAPKNEPKRQLLKLLRTEHPGDAGIVYCLSRSSVEKTAEFLVQNGISALPYHAGLDARTRAANQARFLREDGLVMVATIAFGMGIDKPDVRFVAHLDLPKSVEGYYQETGRAGRDGLPSVAWLAYGLQDVVQQRKMIDTSEGDETHRRRLGTHLDAMLALCEAVECRRVRLLAYFGQDSTACGNCDTCLTPPESWDGTIAAQKLLSTVLRLLRERRQKFGAGQIIDILLGRKTPKVTQFDHHSLTVFGIGTELGEAEWRGVVRQLLAQGLLTVEGDYGTLLLTEASAEVLSRQRQVLLRREPERAARTRSEPSARAGGARRATPADLPEEAVPVFERLRAWRAATAKEQGVPAYVIFHDATLREIATGVPSSLAELGEVSGVGENKLAKYGRQILDTLAQDAVEPDQALIFP
>NC_013595.1|WP_043657343.1|7634768_7636394_+|DUF3459-domain-containing-protein
MVAPCAAPSPVPSAPPSSEWWRDAVIYEIYVRSFADGNGDGIGDLLGVRSRLRYLADLGVDAIWLTPFYPSPMNDGGYDVANYRAVDPRLGTLDDARALVREAHGLGMRVLIDIVPNHTSSEHPWFAEALRDEPGARDRYVFRPGRGQDGAEPPNDWESSFGGPAWTRLPDGSWYLHLFAPEQPDLNWDNPEVRAEFEDVMRFWLDIGVDGFRVDVAHGMVKAEGLPDAGFTGQLKLLGRAPLPFFDQDGVHEILRSWRRLLDSYPGERIGVAEVWPPSPDRLANYVRHDELHQAFNFDYLAADWGAGPLRQVIDASISATDLVGAPTTWVLSNHDQVRHVTRYGGGEQGTRRARAATLLTMALPGSVYLYQGEELGLPEVLDLPDEVLQDPIFLRTAGADRGRDGSRVPIPWAYGESSSGFSPPGADPSWLPIPREWGGQAVIPQLGDPGSVLNLYRNAVRLRRTHPALGRGTMRWLDSPPDTLFFTREPGLLCTVNLGADPVVLESPGTLLLSSGDTRCDGLQAILEPDTAAWWSCTTS
>NC_013595.1|WP_012893357.1|7633032_7634289_-|hypothetical-protein
MPPIDQITAFASDHPVGTVIICVVALVLLGLAYLALRAVYRAGNRFFHRFVAPRPAEDILTIVAASIATGVSAQGMWRFSGDVLGFDGPLRLLLFAFIEVAVITSAVRARRNMRENYSAGIDGIAVWTLTGLSAVLSSMDARSLAEAVFRLAAPLVAAWLWERGMAIERHRITGRARINWRITPERMLVRVGLAEASDRTASEVDAHRRLTRVALAAKRARALREAGASDRRMRAALTKLDRAMDQAVEHTGLAVDAGRQEALLSQIGALYNTSALIDLSPPVPWAPEPEAPRASPALPAAGSYDEDEDEDEEEAEVVETALPVVDTAQRAALMRAAREYWDKQIERKFVPRASDIAHETGITLATAREYRALWKLEPRAHALIEAAYNEHGIIDTGTFPAIETPERVLTVNGSSPAP
>NC_013595.1|WP_012893356.1|7631839_7632667_-|hypothetical-protein
MVWLRRLIEDLRIRQNVDAHVVTVVVFAFAVVSIFGDVVPDQLKWAALLSGVGILVYRLTLPEERPEISTSILGDRSAFDSVPLSSALANARDVRIFAPSAVNLLSAHTCETLRRTVLARAGGSVRVVILDPAEKAAVRMASKQLDDSVDFPIQRLPAALDSAIERLDLMSKWEVEGRFRYRLLPYSPGFSIVLIDPDTSKGRVVVEIHGFHNPSTSSRMHLELSRAQNERWYSYWVRQFDYIWREATQVDVSSAAEADDGPAPADAREGRDRPL
>NC_013595.1|WP_012893355.1|7629933_7631913_+|hypothetical-protein
MTSAGHVQNETGQPYVGLRAFRQQDRGLFFGREREAREIATLWQADRLTVLYGASGVGKTSLLHAGVLPFLGSDRVDILPVGRVAPDPALLVSTTPVRSVYVLSLLSSWSAAPPAELAELTVRDYLDQRPARVDRYDDPIPTLISIDQAEEMFTGAPYRESDLEEFVAQLADALQAHAGLRLLLSMRQEYLASIVPFERVLGQGSRSWFHLLPFRREAALDATRRPLEGTDRRFGENAAELLVDDLQTVTIHSEQGEKTVLRVSGVEPVQLQVVCSALWESLPPDVHEITVDHVRLHANVDRFLAGFCRRMLREVAERHGVPEGSIRSWLRRTFITEHGTRGTAYEGLHQTSGMPNALVRSLEDRHILKAEYRAGARWYELQHDRLIAAIRHTDPETFLQAARTALSRAQWTHARELTEDAVRTAEFDDLGVRAEAEAIFGDVAVGTGDPATAWRRYDAAAEMFAVLQRADGVGRVLAAKGRLSLNLGDYPTAVSALSAAVARVPGDMSAQTALAQALWHVGQPRSALIVLNGALAVGGDALLDALALRGVILADLDQPEAALRDLDLVRQHQQPATLAARALALALAGRFDAAEQEAADAIANAGSNGPVLLRAARIRVILGNAVAGADLAAQAIRADDPALPEHLREQARRLLPPPN
>NC_013595.1|WP_043653446.1|7643648_7644356_-|alpha/beta-hydrolase
MIPGPWMGAWVWEPVTCGLRTLGHHVRPVTLSGLAAPDTDVSSVGLATHVDDVLSLLEADDLRDVILVGHSYSGIVAGQVADRAPGRVARTVFVEGFLPHDGVSMLQAFPERQRAGELQLIDENRGRWPIPDATVVADGQDLSVEQARWLVERFVGHPGRTLSEPAVLTRPLAQQRASYVMCEMEHFDGKVSDDVAAMRAEPNWDFHTLKTGHWPMVSAPEQLVALLAGIASQQN
>NC_013595.1|WP_169369427.1|7644526_7645204_-|4'-phosphopantetheinyl-transferase-superfamily-protein
MLSGTELKRASTYHRDQDRRRFLTACWLLRTTAAAQLGVPPAAVIVERRCPDCDKPHGKPYVRSVGIDLHVSVSHAGNRVAVALSTAGPLGVDVEEVPTGPVDGLAQCALSPAELAVLQALPEHEQNAAFARIWVCKEAVLKATGHGLRIPPDQVEVSGPQEEPALLGWPLDIHPSTVQIHPLAPGGGYAGVVAVLADDLPIIVSESDALDLHLIQLSAPVSMAA
>NC_013595.1|WP_174435271.1|7645187_7645571_-|hypothetical-protein
MLVELTMRRTGGEPSGNSPIDGIRILALLPEKWRKDLKQATGEIVIRIQTDEDITSEQICVRVVAILTDPTVSHWKLATCHTLTTENREPKEATHDYSRFADWRVQRVVGGSTGSADRRPDQRAQWN
>NC_013595.1|WP_169369429.1|7645587_7645752_-|hypothetical-protein
MFSPAIVAGAVLCSAVIGGHSAPAAEGGPWGVESQFAAAGTPWGSASTDGTTWD
>NC_013595.1|WP_012893369.1|7646744_7648424_-|acyl-CoA-carboxylase-subunit-beta
MSTSELDFILVPLPAPAEEGVNGRPDEHPNGRLHAKPPAPPPQIRSMSLLREQRERLREEVVAGRRQAVDRQHTLGKRTARERIDLLLDEGSFTEIDMYRRHQAHGLRIEEQRPHTDGVVTGSGTIHGRRVFVYAQDFTLFGGSLGEAHASKIHKVMDLAISTGSPFIGLNDSGGARIQEGVMSLNGYGGIFQRNVQASGVIPQISVVLGPCAGGAAYSTALADFTFMVRDTAQMYLTGPDVVEAVSGQRVTHAELGGAEVHGGRSGVATFVHDDEESCLEDVRYLVSMLPSNNLDLPPSAPSCDAATDVRPRLAEIVPVEPNKPYDMRQVVAELVDDGDFLELHENWAPNVICVLARIDGDVVGVVGNQPMVLAGVLDVAASQKAARFVRFCDAFSIPLVTLVDVPGFLPGTDQEYAGIIRHGAKLLYAYCEATVPRIQVILRKAYGGAYIVMDSRSIGTDLSLAWPTNEIAVMGAEGAVNVIFRRELAAAADPAELRSELVAEYSEQLVHPHYAAERGLVDDVIDPVQTRSAVARGLAMLRDKRKQPPQRKHGNVPL
>NC_013595.1|WP_012893370.1|7648497_7649541_-|NAD-dependent-epimerase/dehydratase-family-protein
MLVSATGGTGFVGAHSVAAIVGMGHRVRMLVRDVSKVKRALAPLNVDLDAVDVVTGDVTDADSVARAVRGADAVLHAASVYSFDSRLHMRMRQVNERGTEIVLDAARRAGADPIIHVSSVVAMFPARGQVIHEDSPVGRPRETYMASKAAAEVIARRHQAEGAPVVITYPPALLGPDDPNLGDQNARLRSVLRGLTPLWPLGGFPVGDVRDTAALHARLLAAPGDRPGRHFGPGRYLSTRQYVEVLREVTGRALPTIFLPARGMIPVGRFVDLVQRVWPWHIPAEYGAIYTCACATRPAEGVSTHGISPRPIAETVGDTVRWLRESGHLSARQAGSGRPSLSSVPTQ
>NC_013595.1|WP_012893371.1|7650046_7650334_+|hypothetical-protein
MLVELTMRRTAGEPVGNSPVDGIRILALLPERWRKDLRQATGDVVIRVHTDEDVTGAQIRAEAIEALTDPAISHWELADCHVLTIGRPGPGRDAL
>NC_013595.1|WP_012893372.1|7650449_7651436_-|response-regulator-receiver-protein
MDISVIGISAEAEELYRYFLRHRGEGIGSVRQALNLDPDTIEAAAEVLGRLSLLDLTDRHRVVATEPRIGIERLVEQRLDQLNMEIRRVLAARDAIASLVEDQRHGENSTPVLDIERVEGLDQVRQRLDDLGFFSYKETLCLHPGGPLSRGAIETALPLDTRSLRRGLAVKAVYHPKALDDPFMAAYLRDVVSLGGQIHITEDPMDRMLIFDRSVAVVPINPKESSRGALLVREPGLVSQLVTYFDGVWQSAVDLRDFTEPSTGAPLLSDLEKRVLAVMATADKDEIAAREIDVSVRTYRRYVADLMARLGAVNRFQAALRAKEENWI
>NC_013595.1|WP_012893373.1|7651571_7652027_-|MarR-family-transcriptional-regulator
MGGDGSEPAPAPGLLAESTGWLLNGAAREVTLELEEVLKDDDLRWRDYGVLGVLEASGPLSQQEIGRRLAVDRSTMVHIIDVLEQRGLVVRSRDRADRRAYSIELTDAGRALLVEVLHPVTAAVHDRVIGRLTREDRAHLNRILAQLAGGA
>NC_013595.1|WP_169369431.1|7652505_7652928_+|MarR-family-transcriptional-regulator
MSKANDLFVEIFESAVEPFGLRSKDFIVLTAIDSMGPQSQQQLARTHGIDRTTMVSVVDGLERLGLVQRARNPDDRRKYAIGLTSEGQALLRHKLTPTMLNAMDAFLAPLTPDERELFNKLLWRLVYERPPAKSSGAGAS

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Crispr_ID: NC_013595_43

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_43

7767769-7767978

Orphan

Consensus_repeat	Method
CACGGCCTGCCCCGCGTC	CRT

3 spacers

WYL

The CRISPR arrays of NC_013595_43

>merge|NC_013595|43|7767769-7767978|CRT
CACGACCTGCCCCGCGTCCTGACTGCCCCGCCCGCGTCCTGACCCGGCCTGCCCCATGTCCTGACTGCCCCGCCCGCGTCCTGACCCGGCCTGCCCCATGTCCTGAGCGCCCAGCGCGGCGGTCCCGGCCCGGCCTGCCCCGCGTCGATGAGGGCCCCGCCACGGCCTGCCCCGCGTCGATGAGGGCCCCGCCACGGCCTGCCCCGCGTC

>NC_013595|43|2|7767769-7767978|CRT
CACGACCTGCCCCGCGTC	CTGACTGCCCCGCCCGCGTCCTGACCCGGCCTGCCCCATGTCCT
GACTGCCCCGCCCGCGTC	CTGACCCGGCCTGCCCCATGTCCTGAGCGCCCAGCGCGGCGGTCCCGG
CCCGGCCTGCCCCGCGTC	GATGAGGGCCCCGCCACGGCCTGCCCCGCGTCGATGAGGGCCCCGC
CACGGCCTGCCCCGCGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012893466.1\|7758643_7759807_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NC_013595.1\|WP_012893468.1\|7761029_7761341_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893469.1\|7761400_7761859_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239316
NC_013595.1\|WP_052317098.1\|7774256_7774616_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377691
NC_013595.1\|WP_148269757.1\|7756977_7758444_+\|replication-initiation-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893480.1\|7774626_7775787_+\|glutathionylspermidine-synthase-family-protein	unknown	unknown	gnl\|CDD\|367631
NC_013595.1\|WP_012893471.1\|7762494_7762902_-\|YjbQ-family-protein	unknown	unknown	gnl\|CDD\|376651
NC_013595.1\|WP_012893475.1\|7770055_7770556_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893483.1\|7777799_7778705_+\|ACP-S-malonyltransferase	unknown	unknown	gnl\|CDD\|223408
NC_013595.1\|WP_148269291.1\|7755976_7756840_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_013595.1\|WP_012893477.1\|7772214_7773201_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_013595.1\|WP_012893478.1\|7773364_7774066_-\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_013595.1\|WP_012893470.1\|7761942_7762371_-\|DUF3052-domain-containing-protein	unknown	unknown	gnl\|CDD\|378615
NC_013595.1\|WP_012893476.1\|7770648_7772127_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_013595.1\|WP_012893474.1\|7768078_7769881_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270408
NC_013595.1\|WP_052317218.1\|7776573_7777683_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NC_013595.1\|WP_043657387.1\|7775850_7776282_+\|DUF350-domain-containing-protein	unknown	unknown	gnl\|CDD\|377187
NC_013595.1\|WP_012893467.1\|7759970_7760918_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NC_013595.1\|WP_012893472.1\|7763385_7766133_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	unknown	unknown	gnl\|CDD\|236500
NC_013595.1\|WP_012893465.1\|7758440_7758647_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012893466.1\|7758643_7759807_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.22093e-24
NC_013595.1\|WP_012893483.1\|7777799_7778705_+\|ACP-S-malonyltransferase	gnl\|CDD\|223408	COG0331, FabD, (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism].	9.17562e-77
NC_013595.1\|WP_012893469.1\|7761400_7761859_-\|peroxiredoxin	gnl\|CDD\|239316	cd03018, PRX_AhpE_like, Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater similarity to 2-cys PRXs than 1-cys PRXs. PRXs are thiol-specific antioxidant (TSA) proteins that confer a protective role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. The first step of catalysis is the nucleophilic attack by the peroxidatic cysteine on the peroxide leading to the formation of a cysteine sulfenic acid intermediate. The absence of a resolving cysteine suggests that functional AhpE is regenerated by an external reductant. The solution behavior and crystal structure of AhpE show that it forms dimers and octamers.	2.9819e-72
NC_013595.1\|WP_052317098.1\|7774256_7774616_+\|hypothetical-protein	gnl\|CDD\|377691	pfam06693, DUF1190, Protein of unknown function (DUF1190). This family consists of several hypothetical Enterobacterial proteins of around 212 residues in length and is known as YjfM in Escherichia coli. The function of this family is unknown.	0.0073078
NC_013595.1\|WP_012893480.1\|7774626_7775787_+\|glutathionylspermidine-synthase-family-protein	gnl\|CDD\|367631	pfam03738, GSP_synth, Glutathionylspermidine synthase preATP-grasp. This region contains the Glutathionylspermidine synthase enzymatic activity EC:6.3.1.8. This is the C-terminal region in bi-enzymes. Glutathionylspermidine (GSP) synthetases of Trypanosomatidae and Escherichia coli couple hydrolysis of ATP (to ADP and Pi) with formation of an amide bond between spermidine and the glycine carboxylate of glutathione (gamma-Glu-Cys-Gly). In the pathogenic trypanosomatids, this reaction is the penultimate step in the biosynthesis of the antioxidant metabolite, trypanothione (N1,N8-bis-(glutathionyl)spermidine), and is a target for drug design. This region, the pre-ATP grasp region, probably carries the substrate-binding site.	0
NC_013595.1\|WP_012893471.1\|7762494_7762902_-\|YjbQ-family-protein	gnl\|CDD\|376651	pfam01894, UPF0047, Uncharacterized protein family UPF0047. This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.	3.1745e-37
NC_013595.1\|WP_148269291.1\|7755976_7756840_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	4.21715e-28
NC_013595.1\|WP_012893477.1\|7772214_7773201_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	6.49409e-27
NC_013595.1\|WP_012893478.1\|7773364_7774066_-\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	2.46809e-41
NC_013595.1\|WP_012893470.1\|7761942_7762371_-\|DUF3052-domain-containing-protein	gnl\|CDD\|378615	pfam11253, DUF3052, Protein of unknown function (DUF3052). This family of proteins with unknown function appears to be restricted to Actinobacteria.	9.2105e-66
NC_013595.1\|WP_012893476.1\|7770648_7772127_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.75348e-55
NC_013595.1\|WP_012893474.1\|7768078_7769881_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.29133e-82
NC_013595.1\|WP_052317218.1\|7776573_7777683_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	1.84257e-18
NC_013595.1\|WP_043657387.1\|7775850_7776282_+\|DUF350-domain-containing-protein	gnl\|CDD\|377187	pfam03994, DUF350, Domain of Unknown Function (DUF350). This domain occurs in a small set of of bacterial proteins. It has two transmembrane regions, and often occurs as tandem repeats. The are no conserved catalytic residues.	1.63326e-07
NC_013595.1\|WP_012893467.1\|7759970_7760918_-\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	2.15191e-65
NC_013595.1\|WP_012893472.1\|7763385_7766133_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	gnl\|CDD\|236500	PRK09405, aceE, pyruvate dehydrogenase subunit E1; Reviewed.	0
NC_013595.1\|WP_012893465.1\|7758440_7758647_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	1.20768e-06

>NC_013595.1|WP_012893472.1|7763385_7766133_+|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type
MASGRQRFSVISDGLPSQLPDVDPSETQEWLESLDNVIKTEGRTRARYLMLRLLERARENQVGVPGLRSTDYINTIPPEREPWFPGDEYVERRIRAYIRWNAAVMVTRANARTNVGGHIATYASAASLYEVGFNHFFRGKDHGESGDQVFIQGHAAPGIYARAFLEGRLNEAQLDAFRQELSHGFKGLPSYPHPRLMPDFWEFPTVSMGLGPIGAIYQARFNRYLLNRKIKDTSRSHVWCYLGDGEMDEPESLGAIGLAAREELDNLTFVINCNLQRLDGPVRGNGKIIQELESYFRGAGWNVIKVVWGRDWDPLLAADVDGVLVNKMNTVPDGQFQTYSVESGEYIRENFFGGDPRLRKMVEHLSDEDIRKLSRGGHDYRKVYAAYKAAREHVGQPTVILAQTIKGWTLGKDFEARNATHQMKKMSKADLKEFRDRLYLPIPDSALEGDLPPYFHPGENDPEIEYMKERRAALGGFLPKRVMRAKPVKLPGDAAYAQLKKGSGKQNVATTMAFVRLLKDLMRDKEIGHRFVPIIPDEARTFGLDAIFPTAKIYSPHGQTYDAVDRELLLSYKESTEGQILHEGISESGSMASTIAVGSAYATHGEHMIPIYIFYSMFGWQRTADQMWQLADQMGRGFLLGATAGRTTLNGEGLQHEDGHTPLIASTNPAAVSYDPSWGFEVAHIVKDGLRRMYGEQPENVFYYLTVYNEPYPQPAEPADLDLEGLLKGLYRFAPAPAVQGPKANILVSGVAGPWAMEAQRMLAEEWGVAAEVWSATSWAELRREALAAEEHNLLNPDSEQRVPYVTQALSAAQGPFVGVSDYMRAVQDQIAQWVPGDWTSLGTDGFGLSDTRSALRRHFHVDAASITLAVLTQLVRRGELDSAVLNDAIARYHLKNGVTEAGGAESNDTQSMGL
>NC_013595.1|WP_012893471.1|7762494_7762902_-|YjbQ-family-protein
MRSQTIEVVTGSRERVHNITAECESFVRSCGGDGLLNVFVPHATAGIALIELGSGSDDDLIAALKDLLPADDRWRHAHGSRGHGRSHVMPALIPPYATVPVLSGRLALGTWQSIAVVDLNVDNRERQVRLSFLSD
>NC_013595.1|WP_012893470.1|7761942_7762371_-|DUF3052-domain-containing-protein
MSATAGQAQGERSLAERLGLKPGQVVQEIGWDEDADDDLRDSIEELTGNELVDEDFEDVVDIVLLWWRDGDGDLFDALSSVLTNLSEGGQIWLLTPKAGRDGHVEPSDIGEDATTAGLSQTSSISAAPDWSGTRLATPKARR
>NC_013595.1|WP_012893469.1|7761400_7761859_-|peroxiredoxin
MAVEVGSPAPDFELKDQHGTPVKLSDYRGRKVVLIFYPLAFSGVCHGELCAIRDEFIATAPEDVQVVTVSVDSVFTHRAWADREGYTFPLLSDFWPHGQVAQAYGVFDEEKGLATRGTFIIDGEGVVRWSVVNPIPEARDVAEYRKALAELS
>NC_013595.1|WP_012893468.1|7761029_7761341_-|hypothetical-protein
MPCFSCGARQSDPIRGASPWKRGVRQEAQVLICPDCQRAHDLDLDTCSTCGSVALICRLGEVECRSCGAVRPARAGGQAAVSCAPGLADEVEAALNRVLGRVH
>NC_013595.1|WP_012893467.1|7759970_7760918_-|ROK-family-protein
MSSFVVALDVGGTSMKGGLVTRSGEILRTDRRATPRDEGPAAVVATIRSFIDDLAVAGGGTPEGVGLAVPGLVTADAALYSANIGWRDVPAADFVPLDVPVMLGHDVRTGGLAESVLGAGREVSDFLFLPIGTGIAGAVIVDGEPYGGAAGWGGEIGHIPVFPEGETCACGQIGCLETYASASAVSRRYSARAASPATAEQVAALTVSGDPVAAEVWDDAVEALSLALATYTLLLDPSAIVLGGGLAEAGPLLADPLADRLRKRLTFRAAPPLRPAALGVNAGMLGAALLGWRAAGVPDAGTTWSLDVLKSPRVA
>NC_013595.1|WP_012893466.1|7758643_7759807_+|site-specific-integrase
MTTRRSRGDGGLHWDETRERWIASVTVGYTPAGKRIVKKASGKTKTEAKDRLKEIMRDYDDGLAIAPANYTVADAVKYWLQHGLGGRSATTVKMYTTFADNHVIPAVGARKLRDLSVEDVDRWLASKTGELSTRSLKLIHGILNRSVKSAMRRDKVKRNVVDLCEIPEGRAGRTSKALTLAQAESVIALAEKANARMRAYIVLSLLIGARTEELRALLWSHVVAFDEERKAWLPVADTGWDHEQFAIYVWRSVRQKGDTKTVKSRRSLKLPRRCVDALRALREEQEKAETEAGLVFSTSKGTPMSAGNVRRDMRKILEKAGLRATDWTPREMRHSFVSLLSDSGVPIEDISRLVGHRNTGVTETVYRKQIRPVLMQGAEAMDDIFKS
>NC_013595.1|WP_012893465.1|7758440_7758647_+|helix-turn-helix-domain-containing-protein
MTAPGPPGERRLYRICDAMHLLSMSRSVIYEQIRAGRLRSVTQGRTRLIPASAISDYIALLEQETRAS
>NC_013595.1|WP_148269757.1|7756977_7758444_+|replication-initiation-protein
MDQQPEWLVDLARVINDPGYARWRSMVAATGGCAHPVHLAGEALIVNATSGEVLHSYRTTDEPSGHLLVACGNRRASVCPACSEVYRADTFQLIRAGLSGGKGVPQEVSGHPRAFVTLTAPSFGPVHTRREKGGTVRACRPRKRDKICEHGHPVGCHARHEPGDERLGQPICGQCYDYVGAVLWQAHAGALWHRFTLEVRRTLASEAGLSRREFAKRVRVSFAKVAEYQRRGLVHFHAIVRLDGLGGGSEIPPDWADHGLLTRAIPPAVQRVTVTSPPSDLGRWDLVWGDQLDIRPILLDQGPDGLSERAVAGYIAKYATKGAEASGTVDHRLSCPACKGRGRLSLMASCGRCHGTGLKPGLHLDALPVTEHARRMIRTCWELGARPEYKALRLRPWAHMLGFRGHFSTKSRRYSTTFGDLRQVRTTHRATEARERHGLPPLGDETTLVLGHWRFTGSGYSPGEAIMAEHIRQKVATARKIATEREDG
>NC_013595.1|WP_148269291.1|7755976_7756840_-|GntR-family-transcriptional-regulator
MEEGELGMTDEKGTARWRIIADLLRSDVVQDHYQPGQALPGEAFLASEYATSRPTIRKAIAQLVGEGLLTVAHGRGTFVRPTPDRRLILMGGSEREDLLSPTYDPAKQGWEHVTVASEAERTAGGVTPNSALFMIIEGSKADVLGVRRGRMSVYRYAYWQHTKTRARIHLCSYLLADQVATITGEGRGMEIDSEIEPEDYYAHLERTHGPLRWITSVHTQMPYGETYEDLNMEPIGTPLLLVRRLMLSKDGRPLEFTEIEAPGDRFEAAAASEHDQAGSDGQVSLRV
>NC_013595.1|WP_012893474.1|7768078_7769881_-|transporter-substrate-binding-domain-containing-protein
MPEIRPLRPGDPPQLGSYTLRGRLGEGGQGVVYLGESEDGERAAIKLLHVRFTGEAQARSRFARELTAARRVAAFCTARVLVADLDGETPYIASELIDGPSLRQVVERDGPLGGEALERLAIGTATALTAIHQAGIAHRDFKPDNVLLAADGPRVVDFGIAKIIDESGTITTRAVGTPAYMAPEQIADEHVGLPADVFAWASTIVFSATGKAPFGGDTIVATLNRVINHEADLSALPGDLRATVASCLNKDQRLRPTSDEVLKRLLGHPVDESEASEEVLAEGAQAATVDLTRVETRPTARRRRRMAATAAATAALGLAATFAVLQFGPAFGGNATVLPGRGTPTPAPESTVRSPLLDRIKAGGVLRVGYRDGFPGVSLGVPPTGFEVEVAEYIARALKVPEGKVRFVPVGYADREAAVERGKVDLVIANLSIDSADRSRVAFAGPYYVAHRDVLVRAGMKISEVGHLRGKKLCLAAGQSTGSMISDMGVTFVAVHDNDTSRCANRVADGRADALPGDDVLIAGFGARLRGPGLKIAGIRLTTERYGVALRSGDPRACQAINGAIRAMYADGTMQALLERNFGRVGFRFETGLPRLEDCR
>NC_013595.1|WP_012893475.1|7770055_7770556_+|hypothetical-protein
MRKVMAVAIASLAALTACGQAGSDGAASVTGATPSASPSTSPQADGLKFARCMRENGVDMPDPEPGGDAVIIRGKINKKNLERASRACEKYSPTGPGKRTVATREFQDAILGFARCMRENGAEVEDPDFSHGKVRFGENGIKVGTSQSREAMEACREQLPGVGKRP
>NC_013595.1|WP_012893476.1|7770648_7772127_-|MFS-transporter
MDEDVRSRGPVQDSAGTAAAADPRRWRALAVLALVQFMFTVDSSIVNVALPSVQRELGASTADLAWVVNAYVVTAGGLLLLGGRLADLWGRRRMFLVGTAVFAVASLTSGIAASTGMLVASRFGQGLGEALAAPAALSMIALMFADSRERARALAIWGGLSGLGATAGVLLSGALTELAGWRWVFFVNLPVAAVALLVTPRLVAARPGSGGRRVDWAGAVLVTAGLIALIAGLLAAGHNGWTAPAVLVPLGAGLAALAGFVAVETRTAEPLVPLRFFASRVRLSANLATIMLTSGMAATMFLLTLYMQNVLGYQPLATGLAYLPFCVAFLGGLMASTALTARLGTTGTICAGLLLSAVGMAYLALRMSVTSGYAADVLPATVMIAAGLGIAFPTLQNAALHGVTDDDAGLGSGVQTTMQQLGSALGLAVFAAIAIGRTGAALASGDSAPAAAVSGYQWAFSVAAGVLVLTALLMPVTVRSVRETGDEARAGG
>NC_013595.1|WP_012893477.1|7772214_7773201_+|LysR-family-transcriptional-regulator
MDLDLRQLQAFVTTSEELHFGRAASRLFLTQQALSHRIRRLEATLGGPLFVRGHHVVELTDLGRRLLPLSRQALAVADEIVAAAQLGRQPLRLDTFRPIAASALLRRLITDLGDLPLELSTRHSLGTALSALQRAEIDVAFGRVHGLPHPWPDDLAHRLLRLEPLHALMSERHPLATRPTLRPADLRPQGIWTPALAGATELDGYLRALGDHFRIPLAIGPAVATLDQVVAQIHAHPDRVWLIDADVQTAHIPATALIPLVDPTPLYPWSLVWRHDNRHPLLPRLLRTAAATARREGWLRYEPARHWLPAEDRAAATGAAPIDRDGAG
>NC_013595.1|WP_012893478.1|7773364_7774066_-|WYL-domain-containing-protein
MNRTDRLYALVEELSAVSPRFRSARELAAGFEVSVRTVERDVSALQQAGVPVHAEPGGRGSYALGRSVPPPPLTFTSDEAVAVAVALERAGDHPFGIHARSALRKLAAAMSPATDAGAGEPVSRVHTAVEPEPYPRASRVIEQALLHRRVLRIEYEDRKGRITRREVEPAIFVGGRGGHWYLVGMCRLRQDARVFRLDRIGWAEETEEVSPEHPPERFASQIPHMLAGNPDLG
>NC_013595.1|WP_052317098.1|7774256_7774616_+|hypothetical-protein
MKASTVITLTGIGVVSLLLIGYCSAQDDDYEEVGADCVDVNSLEPDGSYTVVDEDYCDDDTHYYGSRGAYSWYYGGVRTGARITQGTTVRPSDVRITSRNGTVIQRGGFGGRSGWGSGS
>NC_013595.1|WP_012893480.1|7774626_7775787_+|glutathionylspermidine-synthase-family-protein
MRRETSLPRDGWESIIEGHGLAYHRSAHPDGLDRPYWDESVQYVFSMDEVLDLENQVEELHRMCLHAVEHVVAHGRYADFAIPEWVAPEIARSWERSDPHLFGRFDLRYDGTGPAKLLEYNADTPTSLLESSVVQWFWLRDRYPDDDQWNSIHERLIDRWQQIAAGLPTGPAHFAWTNMDETGEEAMTLAYLQETADQAGLKTIAVAMEDIGWDSLNLRFVDMERRVIRSLCKLYPWEWAVADPFGARAVRQQVSMTWIEPLWKMLLSNKALLAVLWELYPGHPNLLPAYLDGPRDMPSHIAKPLLGREGANMRIVTPGDRVETPGGYGAEGHVYQEFQPLPVFDGWRPVLGAWIIHDEAAGVGIRETSGFITDDTSSFVPHRIEL
>NC_013595.1|WP_043657387.1|7775850_7776282_+|DUF350-domain-containing-protein
MSLAETLGRGALAIVSYAALGVILLIIGFYVIDMAIPGKLSHLIKSDRNPNATLLTASGLAAVGLIVAASIWSSGGALHEGLLATAVFGLVGIAVQTVAMIAFDKIAGMSVRDLVSEPDLQPGARLLAVTHLVIGLITAVAVI
>NC_013595.1|WP_052317218.1|7776573_7777683_+|helix-turn-helix-domain-containing-protein
MGTLGTAAMARMDDRLMWFRALSAEDRSWVGLVAQAGIAAFVEWFQHAGEGRPTPSIEFFGTAPRELKRSISLQQTVDIVRIVVEVVEAQTGDLAAPGGEDQLQQAMLRYTRDVAFAAAQVYAREAEARGAWDARLEALIVDALVRGEVDDGLHSWAAALGWISSPVVVLAGQTPDDDPQAVIDGLRDRGRRSGLDMLAGVQGDRLIVIVGGADSVSAAARHVVPRFGPGPIVIGPEVNDLHAAARSARAAIAGLRAAGGWPDAPRPVHAEDLLAERAIDGDADARGQLVENVYLPLVGTPLLDTLATYLEQGTSLEATARLLFVHPNTVRYRLRKITELTGYQPTEGRSAFTLQVGLILGRLSETIGT
>NC_013595.1|WP_012893483.1|7777799_7778705_+|ACP-S-malonyltransferase
MLVIVAPGQGAQTPGFLAPWLEIPGLADRLSAWSDLVGLDLVAYGTTAGADEIRDTAVAQPLLVAAGLAVAEVLGASPSIVAGHSVGELTAAVLAGVLTPEQALTLVRERGQAMAKAAAVTETGMVAVLGGAEDEVLAAIAGHGLTPANINGAGQIVAGGTLAQLEAFRAEPPARARLIPLSVAGAFHTVHMAPAVDQLRKAAAGITPGDPSTTLLSNADGAAVTSGAEFVERLINQVANPVRWDSCMATMADRGVTAMIELVPGGTLTGLAKRALRGVATVALKTPDDLDAARGVLSGSA

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Crispr_ID: NC_013595_44

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_44

7924080-7924191

Orphan

Consensus_repeat	Method
CCCGAAGCCCGATCACTGCACCACCACGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_44

>merge|NC_013595|44|7924080-7924191|CRISPRCasFinder
CCCGAAGCCCGATCACTGCACCACCACGAAGTGACGCCCCCCTCCGAAACCGGATCGGTCCACCCCGACGGAACAGCCCATCTCCCGAAGCCCGATCACTGCACCGCCACGA

>NC_013595|44|41|7924080-7924191|CRISPRCasFinder
CCCGAAGCCCGATCACTGCACCACCACGA	AGTGACGCCCCCCTCCGAAACCGGATCGGTCCACCCCGACGGAACAGCCCATCT
CCCGAAGCCCGATCACTGCACCGCCACGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012893598.1\|7922674_7923445_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|379263
NC_013595.1\|WP_012893594.1\|7917660_7919085_-\|beta-glucosidase	unknown	unknown	gnl\|CDD\|274539
NC_013595.1\|WP_012893599.1\|7923582_7923957_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|223619
NC_013595.1\|WP_148269766.1\|7914313_7915687_+\|beta-glucosidase	unknown	unknown	gnl\|CDD\|274539
NC_013595.1\|WP_169369445.1\|7930893_7931058_+\|Tn3-family-transposase	unknown	unknown	gnl\|CDD\|376561
NC_013595.1\|WP_012893607.1\|7932945_7933104_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893591.1\|7912760_7914116_-\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NC_013595.1\|WP_012893603.1\|7927762_7928731_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367483
NC_013595.1\|WP_012893610.1\|7935745_7936018_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893604.1\|7929960_7930830_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271175
NC_013595.1\|WP_148269767.1\|7919081_7919840_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223472
NC_013595.1\|WP_012893593.1\|7916664_7917660_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_013595.1\|WP_012893597.1\|7921037_7922339_-\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NC_013595.1\|WP_012893608.1\|7933806_7934661_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893596.1\|7919929_7920901_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_013595.1\|WP_012893606.1\|7932356_7932929_+\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|223340
NC_013595.1\|WP_012893605.1\|7931711_7932284_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380066
NC_013595.1\|WP_081453490.1\|7936032_7937388_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121
NC_013595.1\|WP_012893590.1\|7911701_7912673_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_013595.1\|WP_012893600.1\|7924316_7925843_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|235108

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012893598.1\|7922674_7923445_-\|SDR-family-oxidoreductase	gnl\|CDD\|379263	pfam13561, adh_short_C2, Enoyl-(Acyl carrier protein) reductase.	8.77178e-71
NC_013595.1\|WP_012893594.1\|7917660_7919085_-\|beta-glucosidase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	0
NC_013595.1\|WP_012893599.1\|7923582_7923957_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	1.92053e-40
NC_013595.1\|WP_148269766.1\|7914313_7915687_+\|beta-glucosidase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	0
NC_013595.1\|WP_169369445.1\|7930893_7931058_+\|Tn3-family-transposase	gnl\|CDD\|376561	pfam01526, DDE_Tnp_Tn3, Tn3 transposase DDE domain. This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli. The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases.	7.83145e-18
NC_013595.1\|WP_012893591.1\|7912760_7914116_-\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	8.01012e-25
NC_013595.1\|WP_012893603.1\|7927762_7928731_-\|hypothetical-protein	gnl\|CDD\|367483	pfam03412, Peptidase_C39, Peptidase C39 family. Lantibiotic and non-lantibiotic bacteriocins are synthesized as precursor peptides containing N-terminal extensions (leader peptides) which are cleaved off during maturation. Most non-lantibiotics and also some lantibiotics have leader peptides of the so-called double-glycine type. These leader peptides share consensus sequences and also a common processing site with two conserved glycine residues in positions -1 and -2. The double- glycine-type leader peptides are unrelated to the N-terminal signal sequences which direct proteins across the cytoplasmic membrane via the sec pathway. Their processing sites are also different from typical signal peptidase cleavage sites, suggesting that a different processing enzyme is involved. Peptide bacteriocins are exported across the cytoplasmic membrane by a dedicated ATP-binding cassette (ABC) transporter. The ABC transporter is the maturation protease and its proteolytic domain resides in the N-terminal part of the protein. This peptidase domain is found in a wide range of ABC transporters, however the presumed catalytic cysteine and histidine are not conserved in all members of this family.	0.00102421
NC_013595.1\|WP_012893604.1\|7929960_7930830_+\|site-specific-integrase	gnl\|CDD\|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.62261e-15
NC_013595.1\|WP_148269767.1\|7919081_7919840_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.36098e-66
NC_013595.1\|WP_012893593.1\|7916664_7917660_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.38211e-96
NC_013595.1\|WP_012893597.1\|7921037_7922339_-\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.15501e-31
NC_013595.1\|WP_012893596.1\|7919929_7920901_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.01242e-77
NC_013595.1\|WP_012893606.1\|7932356_7932929_+\|dihydrofolate-reductase-family-protein	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	6.3925e-15
NC_013595.1\|WP_012893605.1\|7931711_7932284_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380066	pfam17940, TetR_C_31, Tetracyclin repressor-like, C-terminal domain. This is the C-terminal domain found in putative transcriptional regulator, TetR family proteins.	1.92614e-18
NC_013595.1\|WP_081453490.1\|7936032_7937388_-\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	2.3937e-90
NC_013595.1\|WP_012893590.1\|7911701_7912673_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.13838e-68
NC_013595.1\|WP_012893600.1\|7924316_7925843_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|235108	PRK03180, ligB, ATP-dependent DNA ligase; Reviewed.	0

>NC_013595.1|WP_012893599.1|7923582_7923957_+|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MALEKPEIDFPEGDAPAELQIVDIVEGDGQEAKPGHRVSVHYVGVAFSTGEEFDASWNRSDVFDFQLGGGQVIAGWDQGVAGMKVGGRRRLTIPPHLGYGSRGAGARIKPGETLIFVVDLLGVS
>NC_013595.1|WP_012893598.1|7922674_7923445_-|SDR-family-oxidoreductase
MRKPYTPEEILLTGKVAVVTGAARGLGRAIAEALREFGAELALCDRHPIDGFDTLTMTMDVRDPAALEVFAQAVRERFGRVDVLVNNAGGTFHAAFAETSPRGESVLIGENFTQVTAMIRRFLPLMPPGASIVNVTSSEAHQAAPGFAVYAAMKAAVESLTRSLALELAPRGIRVNAIAPDALPTGGEESVRARMLADPLPFEPVRLPPLGHLGDPAEAGAAVVFLASEMAGFVTGTTLHVDGGIHAAGGWRRAEP
>NC_013595.1|WP_012893597.1|7921037_7922339_-|carbohydrate-ABC-transporter-substrate-binding-protein
MRKLRHRFLAPMVAVSALAMGLAACGGDSGGATGSGATASQPAEKIKLTVGLFSDFHYAPLYEEFKKTHPNVEIVERRAQFNDHHTNLITQLTTGAGAADVVAVEGGYIGAFTPVPDKFHNLKDYGLDRRQSEYLDWKWKLGVSNDGSSLIGLGTDVGGLAMCYRPDLFKKAGLPSDRDEVSALWPTWDQYVETGKKFVAAKVAGAKFTDGPGEHFRAMVEQAPVGFYDDQYKIVAGANPEVRKAYDMSVKIIDDGLSAKLAAFTPPWNTGIAKGTFATMVCPAWKTGTIKDQKPGEGVWDIAAVPGGGGNQGGTHLMLPKQGKHPKEAAELIDLLTNKESQIKLFKEASALPSLPALYDDPAVAEFVNPYFGNAPIGKIFTSAAKALKPQHVGPKAGDVLKAFDNGLQRIEQGKQNAEEAWAQALKDVGRIK
>NC_013595.1|WP_012893596.1|7919929_7920901_-|sugar-ABC-transporter-permease
MATRAPDRLAAVPPDRPVRPRRRRHRHLVHQLDVKGSPYAYVAPFFLLFSAFGLFPLAYTAWVSLHEWTLLSDEQTFVGLDNFRTLLADDYFWNATFNTLSIGVLSTAPQLLLAIWLAHLLNRPLRAQTFFRITLLLPNVTSVVAVVVIFSQLFGRDFGMINWMLSLFGVGGVAWNEGVMTSHAAISVMIMWRWTGYNALIFLAAMQAVPRELYEAATIDGANGFTQLRKITIPMIRPTIVFVVITSTIGAMQILAEPLLFGSYSVSGGPDRQYQTLSLFIYENFTKLDFGYASAISWMVFVFIVLVAGVNYLLTRRAKGALT
>NC_013595.1|WP_148269767.1|7919081_7919840_-|ABC-transporter-permease-subunit
MLPLYYSIVVASRDNAALADVPPPLLPGGNFFANVARVFDTVPFAMAMVNSVLVSGSVALAVMFFSTLAGFAFAKLRFRGRNALLLLTVATMMVPTQLGIIPLYMLMVKLEWTGTMYALIVPALVNAFGVFFMTQYLSRALPTELLEAGRVDGCTTWGLFWHVVLPAARPAAAVLGMLTFMSVWNDYFWPLVVLTPEDPTVQVALSTLASGYVNDYVLGLAGTTLGTLPLVVVFALLGKQIIGGIMQGAVKG
>NC_013595.1|WP_012893594.1|7917660_7919085_-|beta-glucosidase
MTIVGIRGASITQGRADFPTGFVWGAATASYQIEGAVKEDGRQPSIWDTFSGTPGKVAGGDTGDVACEHYFHYADDVRLMSDLGLHAYRFSVAWPRVQPDGTGPVNPRGLDFYSRLVDKLLEAGITPYATLYHWDLPQSLEDAGGWPERDTAHRFADYARAVHERLGDRVRHWTTLNEPWVSAFLGYGNGVHAPGRKDPAAALRAAHHLLLGHGLATQALRAGGAEEITLVLNLAPVITPAQVGDPAAGPSPADAEAVNRIDTLLTRQFLDPALRGRYPAELLEIVERNGGLAHIRDGDLTTINQPIETIGINYYNPCVVESGPGEAADAAWPGSEDVRFCAVDAPVTAMGWPIVPNGLSRLLVRLADDYPEVGLIVTENGAAFDDVVEDGRVHDTGRTGYLDGHLRAVHAAIAAGADVRGYLVWSLLDNFEWAEGYRRRFGIVHVDFATQRRLLKDSALWYREVIKRNGLRGN
>NC_013595.1|WP_012893593.1|7916664_7917660_-|LacI-family-DNA-binding-transcriptional-regulator
MRRPTLEAVAARAGVSRSTVSRVVNGQTTVTPDIRDVVMRAVNELGYVPNGAARNLVTQRTNSVALVVSEPPNRVFSDDPMFSTVIRSASIELEAVNMQVVLLLAGSQESHARVETYVAGGHVDGVMLVSSHGADPLPVALTRLRVPVVSYGRPAVPVAMPYVDSDNVGGAAAAVRHLLERGRRRIATIAGPLDMIGGQDRLAGYRDVLRDSDRRSIIAVGDFTRESGAVAMRQLLADDPELDAVFAANDLMAIGAMHALRQAGRRIPDDVAVVGYDDIEAARYTDPPLTTIHNPHAEQAAAMVRLLLGLLEGGPADPFIVSTELVVRTSS
>NC_013595.1|WP_148269766.1|7914313_7915687_+|beta-glucosidase
MSAEQSYVLEDSGVLRFPEGFVWGAATAAYQIEGAAREDGRGPSIWDTFSRTPGKVHAGHTGDVACDHYHRYPDDVRLMGDLGLHAYRFSISWPRIQPDGTGPANPRGLDFYDRLVDELHGTGVTPIVTLYHWDLPQPLEDRGGWTNRETAERFAEYAAIVHARLGDRVETWTTLNEPWCSAFLGYASGIHAPGRSEPGLGFAATHHLLLGHGLAVKALRAAGAGRIGITLNLAPVLGDDAEAASIVDGLQNRIFLDPVLRGEYPADVVERAGRFTDWSFVEDGDLEIISQPVDLLGVNYYHPQTVAARPGEPANPVYPGSEGIAFPRPDVPRTAMGWPVQPFGLTDLLVRLSRDYPGTPLIITENGAAFDDVLEDGRVHDAGRVSYLDGHLRAAHAAIEAGADLRGYLVWSLLDNFEWAEGYDKRFGVVHVDYATQNRTPKDSALWYRDVVRRNGL
>NC_013595.1|WP_012893591.1|7912760_7914116_-|carbohydrate-ABC-transporter-substrate-binding-protein
MSLPSRAGRVTLVAGTIGLALAVTACGSTEPKPSASGGGSTSAECAAFSKYGKHDGKTVSIYSPIRDAEADLFQEAWKPFAKCTGMKITYEGTGEFEAQIQVRADGGNPPDIAFFPQPGLLERFAKAGKLKPASAEVKKLTDEGWSPDWAKYSTVDGTFYGAPLGASVKSFVWYSPKMFKEKGWAVPTTWDELMTLSGTIAGSGVKPWCAGIESGDATGWPATDWIEDILLREIGPEGYDDWVGHKLAFNDPKVVAAVDKVGAILKNDKFVNGGYGPVKSIASTAFQEGGVPITQGKCALHRQASFYANFWPEGTKVAEDGDVFAFYLPGNDPSKKPVLGAGEFVAAFTDRPEVQAVQAYLASAEFPNTRMKLGTYVSARKGVDPANAQNPIDKLSIEMLQDPETVFRFDGSDLMPAAVGAGTFWKGMTDWINGKDTKTVLDYIEASWPKS
>NC_013595.1|WP_012893590.1|7911701_7912673_-|sugar-ABC-transporter-permease
MDFDFAAEQPKLVQLLIGVAAFLVVVAVILLLVDRAPMRRRAWPHATILLLPAVALLGIGLVVPAVRTTLLSFMSGDGLNWVGLDNYAWMFTQPEALTVLRNTLIWVLLVPLLVTTVGLVYAVLVDRTRFESLAKSLVFLPMAISFVGAGIIWRFVYAYRAEDQDQIGLLNQLVVSMGGEPQQWLQEPPLNTLFLIVVMVWIQAGFATVVLSAAIKGIPAEIIEAARLDGASPTQMFFRVTLPSIRSAVIVVLVTQSIGTLKLFDIVRTMTGGQFDTSVIANEMYNQAFRYGETGKGAALAVFLFVLVTPIVIYQIRQRREVR
>NC_013595.1|WP_012893600.1|7924316_7925843_+|ATP-dependent-DNA-ligase
MLLIDLARTSAAVTADSARLAKIGHLAELLGRVDADEAEIAISYLSGELPQRHIGVGWAGLQDPPDPRLAATATLRQVNDLLDRIKAQAGPGSQAARKALIIELFAALTRQEQTFLSRLLRSELRQGALDGVMIEAIAKASAVPTAEVRRALTLRGWLPAVGAAALSGGVNALRAFHLEVGRPVSPMLAQSATSVAAALGKLGGPAAIEWKLDGVRVQAHRSGDAVSVFTRTLDDITAQVPELVEAVRALSSQDLVLDGEVIALRPDGRPEPFQVTSGRVSSRIDVARVRERTPLRVFFFDALRVDGVDLLDLPGEVRHAALAATVPSELVTPRLVTGDAASGEAFFKDVVRAGHEGVVVKSLQTPYAAGRRGAGWIKVKPRHTLDLVVLAAEWGSGRREGRLSNLHLGARDPQTGGFVMLGKTFKGLTDEVLAWQTERFLEIAEGPTDGWTVVVRPELVVEIAFDGVQQSPRYPGGMALRFARVVRYRPDKNADQADTVEMVRSLML
>NC_013595.1|WP_012893603.1|7927762_7928731_-|hypothetical-protein
MSVTYVGSGPYCYANSLAMVLGGEAPPPAVIEVLTGSPYGMQLIGGSLPLFDSFGWDPEVGLDAAIGLLGWECERVDGGTAAAALDRLRRACQDGPVLAGPLELGLLSYQPGAGKAVGADHYVVVLEVSDNTVLVQDPQGYPYATLAVDAFAAAWHGELISYLERPYRMRHRFTRRERVSPEEALRRSLPAGLAWLAGRTDVEVQPGTLGQAEAAERTADLVEEGLDPEIRMLWQAFAVRVGARRLNDLAACLASLGLDTGAAVAAEQARIVGGLQGPLVAGDDMALAAGLRRLAPTYERLRTTLIADEGTSQAMGTPSRRS
>NC_013595.1|WP_012893604.1|7929960_7930830_+|site-specific-integrase
MAIPRTANPNTHRAYASAVDRVITRLGRDRPLAEVADAEIGTALAELWGASASATWNRNRAAITSWLLWCQTKKHWAVPSVPAEAERRKESVDETRAVAKSTIHRLLSRRDIPLREKTLWRMLYETAARAAEILALNVEDLDLEHRRAPVRSKGSTTEWVYWDRGTAHLLPRLLRLPDDTSRTHGPLFLSERRPVPARRPAAADICPHTGRTRLGYDRARVLLDKYAGLDLHRLRHSAATHLGEAEIPLQLIMGKTRRKNPRTAMRYIKPGAEAIAKVTEVLAPRRRTH
>NC_013595.1|WP_169369445.1|7930893_7931058_+|Tn3-family-transposase
MACNKVNLKRIETHWPDMLRVAGSLITNQVRAYDLLRMFGREGHPTPLGAAFAE
>NC_013595.1|WP_012893605.1|7931711_7932284_-|TetR-family-transcriptional-regulator
MRRNPERRQALIDAAIEVLAREGARGLTFRAVDAEAAVPPGTASNYFANRDDLFTQVGGRIYERLLPDEVTIARSREGVQDQTRYAELMHELVDRVSAFNSGYLALLELRLESTRRPELRAVLTKRIREDIDANIGNHAASGLPGDSTSAVLLYLALNWLIVERLTLPDIFTEQEIHELVDAAVQRSLNA
>NC_013595.1|WP_012893606.1|7932356_7932929_+|dihydrofolate-reductase-family-protein
MRKLVYYIGVSLDGYIAGPNAEFDFYPVSDQMAAWMNDRYPETVPTHVRKLVGLEGVPNKVFDTLVMGRGTYEPALDASITSPYSHLRQYVVSSTLTIDDPTVQVETGDPIELIRRLKAEDTGMDIYLCGGGRLAASLLPEIDEIILKNYPVVAGAGIPMFSGQFRPTLFAPTRRETFDNGAQVTWLTRV
>NC_013595.1|WP_012893607.1|7932945_7933104_+|hypothetical-protein
MHIKFPATITQAKAEYQARSPHRHDQPARDLKPTGRTNLSRRPTAVPRRSGY
>NC_013595.1|WP_012893608.1|7933806_7934661_-|hypothetical-protein
MTNWPERVRRLIAAKRPPREMLKALRADAAKDPEAARDLGHMLLQVSWSETQTDGYGYLPEAEKWLRQAVTKRPQDAEATLLLATLLSTQCGQLWDMALGMRHPKRWDEERKRRAIEACDLYERVLQFDPHSSAAASGLALLRETHSLTGRDHSTVSAAIDLDETESYRFDYFVVRVELLVTNNGDTVTRWVVLRDPEQLWGFEICAWEISEPVAFQYEHGVQVAKHRPARLSGRSLSQVTEEWLDKRDPASRATLLPVGHPVCRDGKILQYGVNGAQMADGPL
>NC_013595.1|WP_012893610.1|7935745_7936018_-|hypothetical-protein
MIMPAARFCRIPVAPDGELRGLSMDVAVAVSALSTALYLHGDVEVLAAARRLVAEVQQVEEKVEPFRRPWVSERTREHFAALVEFLAAAP
>NC_013595.1|WP_081453490.1|7936032_7937388_-|hypothetical-protein
MHKTPQPPSQLSPALAPLWDQILATALAKDPQQRHRDAAAMRQAIETGLAAPTAQAPAPVPPSASAPTARLDTPLPIEPAPTEPAPHASALHAPGSSGLGDRSAPASATRDHVAAVPHRVLSRRRLLTGLGAAGLAAALPAAYYTFTREDTATLRGQPLTGHTGVAVSAVAFSPDGKILAADDGYTVRLWDVATRALLGTPLTGHTSWVSAVAFSPDGKILASGSYDDTVRLWDVATNTPIGRPLAGRNNPTGAVSAVAFSPDGKILATDDDDAVRLWDVVTRTPVGRPLTGYTDSLQSVAFSPDGKILATDDDDAVRLWDVVTRTAIGRPLTGHTSWIAAVAFSPDGKILATGSTDDTVRLWDVATRTPVGRPLTGHTDSLQSVAFSPDGKILATGSDDETVRLWDVATRTPVGRPLTGHTDSLQSVAFSPDGKILATGSDDGTVRLWQL

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Crispr_ID: NC_013595_45

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_45

7926487-7926584

Orphan

Consensus_repeat	Method
CACCCTCGCCGCGCTTTTGACCTTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_45

>merge|NC_013595|45|7926487-7926584|CRISPRCasFinder
CACCCTCGCCGCGCTTTTGACCTTCCACCCCGTACGGCGCCGCACGAAAGAAACGGCCCCGGCCACTCCACCCACCCTCGCTGCGCTTTTGACCTTCC

>NC_013595|45|42|7926487-7926584|CRISPRCasFinder
CACCCTCGCCGCGCTTTTGACCTTCC	ACCCCGTACGGCGCCGCACGAAAGAAACGGCCCCGGCCACTCCACC
CACCCTCGCTGCGCTTTTGACCTTCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012893598.1\|7922674_7923445_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|379263
NC_013595.1\|WP_012893594.1\|7917660_7919085_-\|beta-glucosidase	unknown	unknown	gnl\|CDD\|274539
NC_013595.1\|WP_012893599.1\|7923582_7923957_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|223619
NC_013595.1\|WP_148269766.1\|7914313_7915687_+\|beta-glucosidase	unknown	unknown	gnl\|CDD\|274539
NC_013595.1\|WP_169369445.1\|7930893_7931058_+\|Tn3-family-transposase	unknown	unknown	gnl\|CDD\|376561
NC_013595.1\|WP_012893607.1\|7932945_7933104_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893591.1\|7912760_7914116_-\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NC_013595.1\|WP_012893603.1\|7927762_7928731_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367483
NC_013595.1\|WP_012893610.1\|7935745_7936018_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893604.1\|7929960_7930830_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271175
NC_013595.1\|WP_148269767.1\|7919081_7919840_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223472
NC_013595.1\|WP_012893593.1\|7916664_7917660_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_013595.1\|WP_148269768.1\|7938205_7938496_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271180
NC_013595.1\|WP_012893597.1\|7921037_7922339_-\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NC_013595.1\|WP_012893608.1\|7933806_7934661_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893596.1\|7919929_7920901_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_013595.1\|WP_012893606.1\|7932356_7932929_+\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|223340
NC_013595.1\|WP_081453490.1\|7936032_7937388_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121
NC_013595.1\|WP_012893605.1\|7931711_7932284_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380066
NC_013595.1\|WP_012893600.1\|7924316_7925843_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|235108

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012893598.1\|7922674_7923445_-\|SDR-family-oxidoreductase	gnl\|CDD\|379263	pfam13561, adh_short_C2, Enoyl-(Acyl carrier protein) reductase.	8.77178e-71
NC_013595.1\|WP_012893594.1\|7917660_7919085_-\|beta-glucosidase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	0
NC_013595.1\|WP_012893599.1\|7923582_7923957_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	1.92053e-40
NC_013595.1\|WP_148269766.1\|7914313_7915687_+\|beta-glucosidase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	0
NC_013595.1\|WP_169369445.1\|7930893_7931058_+\|Tn3-family-transposase	gnl\|CDD\|376561	pfam01526, DDE_Tnp_Tn3, Tn3 transposase DDE domain. This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli. The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases.	7.83145e-18
NC_013595.1\|WP_012893591.1\|7912760_7914116_-\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	8.01012e-25
NC_013595.1\|WP_012893603.1\|7927762_7928731_-\|hypothetical-protein	gnl\|CDD\|367483	pfam03412, Peptidase_C39, Peptidase C39 family. Lantibiotic and non-lantibiotic bacteriocins are synthesized as precursor peptides containing N-terminal extensions (leader peptides) which are cleaved off during maturation. Most non-lantibiotics and also some lantibiotics have leader peptides of the so-called double-glycine type. These leader peptides share consensus sequences and also a common processing site with two conserved glycine residues in positions -1 and -2. The double- glycine-type leader peptides are unrelated to the N-terminal signal sequences which direct proteins across the cytoplasmic membrane via the sec pathway. Their processing sites are also different from typical signal peptidase cleavage sites, suggesting that a different processing enzyme is involved. Peptide bacteriocins are exported across the cytoplasmic membrane by a dedicated ATP-binding cassette (ABC) transporter. The ABC transporter is the maturation protease and its proteolytic domain resides in the N-terminal part of the protein. This peptidase domain is found in a wide range of ABC transporters, however the presumed catalytic cysteine and histidine are not conserved in all members of this family.	0.00102421
NC_013595.1\|WP_012893604.1\|7929960_7930830_+\|site-specific-integrase	gnl\|CDD\|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.62261e-15
NC_013595.1\|WP_148269767.1\|7919081_7919840_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.36098e-66
NC_013595.1\|WP_012893593.1\|7916664_7917660_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.38211e-96
NC_013595.1\|WP_148269768.1\|7938205_7938496_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271180	cd00799, INT_Cre_C, C-terminal catalytic domain of Cre recombinase (also called integrase). Cre-like recombinases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre recombinase maintains the circular phage replicon in a monomeric state by catalyzing a site-specific recombination between two loxP sites. The catalytic core domain of Cre recombinase is linked to a more divergent helical N-terminal domain, which interacts primarily with the DNA major groove proximal to the crossover region.	1.69232e-06
NC_013595.1\|WP_012893597.1\|7921037_7922339_-\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.15501e-31
NC_013595.1\|WP_012893596.1\|7919929_7920901_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.01242e-77
NC_013595.1\|WP_012893606.1\|7932356_7932929_+\|dihydrofolate-reductase-family-protein	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	6.3925e-15
NC_013595.1\|WP_081453490.1\|7936032_7937388_-\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	2.3937e-90
NC_013595.1\|WP_012893605.1\|7931711_7932284_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380066	pfam17940, TetR_C_31, Tetracyclin repressor-like, C-terminal domain. This is the C-terminal domain found in putative transcriptional regulator, TetR family proteins.	1.92614e-18
NC_013595.1\|WP_012893600.1\|7924316_7925843_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|235108	PRK03180, ligB, ATP-dependent DNA ligase; Reviewed.	0

>NC_013595.1|WP_012893600.1|7924316_7925843_+|ATP-dependent-DNA-ligase
MLLIDLARTSAAVTADSARLAKIGHLAELLGRVDADEAEIAISYLSGELPQRHIGVGWAGLQDPPDPRLAATATLRQVNDLLDRIKAQAGPGSQAARKALIIELFAALTRQEQTFLSRLLRSELRQGALDGVMIEAIAKASAVPTAEVRRALTLRGWLPAVGAAALSGGVNALRAFHLEVGRPVSPMLAQSATSVAAALGKLGGPAAIEWKLDGVRVQAHRSGDAVSVFTRTLDDITAQVPELVEAVRALSSQDLVLDGEVIALRPDGRPEPFQVTSGRVSSRIDVARVRERTPLRVFFFDALRVDGVDLLDLPGEVRHAALAATVPSELVTPRLVTGDAASGEAFFKDVVRAGHEGVVVKSLQTPYAAGRRGAGWIKVKPRHTLDLVVLAAEWGSGRREGRLSNLHLGARDPQTGGFVMLGKTFKGLTDEVLAWQTERFLEIAEGPTDGWTVVVRPELVVEIAFDGVQQSPRYPGGMALRFARVVRYRPDKNADQADTVEMVRSLML
>NC_013595.1|WP_012893599.1|7923582_7923957_+|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MALEKPEIDFPEGDAPAELQIVDIVEGDGQEAKPGHRVSVHYVGVAFSTGEEFDASWNRSDVFDFQLGGGQVIAGWDQGVAGMKVGGRRRLTIPPHLGYGSRGAGARIKPGETLIFVVDLLGVS
>NC_013595.1|WP_012893598.1|7922674_7923445_-|SDR-family-oxidoreductase
MRKPYTPEEILLTGKVAVVTGAARGLGRAIAEALREFGAELALCDRHPIDGFDTLTMTMDVRDPAALEVFAQAVRERFGRVDVLVNNAGGTFHAAFAETSPRGESVLIGENFTQVTAMIRRFLPLMPPGASIVNVTSSEAHQAAPGFAVYAAMKAAVESLTRSLALELAPRGIRVNAIAPDALPTGGEESVRARMLADPLPFEPVRLPPLGHLGDPAEAGAAVVFLASEMAGFVTGTTLHVDGGIHAAGGWRRAEP
>NC_013595.1|WP_012893597.1|7921037_7922339_-|carbohydrate-ABC-transporter-substrate-binding-protein
MRKLRHRFLAPMVAVSALAMGLAACGGDSGGATGSGATASQPAEKIKLTVGLFSDFHYAPLYEEFKKTHPNVEIVERRAQFNDHHTNLITQLTTGAGAADVVAVEGGYIGAFTPVPDKFHNLKDYGLDRRQSEYLDWKWKLGVSNDGSSLIGLGTDVGGLAMCYRPDLFKKAGLPSDRDEVSALWPTWDQYVETGKKFVAAKVAGAKFTDGPGEHFRAMVEQAPVGFYDDQYKIVAGANPEVRKAYDMSVKIIDDGLSAKLAAFTPPWNTGIAKGTFATMVCPAWKTGTIKDQKPGEGVWDIAAVPGGGGNQGGTHLMLPKQGKHPKEAAELIDLLTNKESQIKLFKEASALPSLPALYDDPAVAEFVNPYFGNAPIGKIFTSAAKALKPQHVGPKAGDVLKAFDNGLQRIEQGKQNAEEAWAQALKDVGRIK
>NC_013595.1|WP_012893596.1|7919929_7920901_-|sugar-ABC-transporter-permease
MATRAPDRLAAVPPDRPVRPRRRRHRHLVHQLDVKGSPYAYVAPFFLLFSAFGLFPLAYTAWVSLHEWTLLSDEQTFVGLDNFRTLLADDYFWNATFNTLSIGVLSTAPQLLLAIWLAHLLNRPLRAQTFFRITLLLPNVTSVVAVVVIFSQLFGRDFGMINWMLSLFGVGGVAWNEGVMTSHAAISVMIMWRWTGYNALIFLAAMQAVPRELYEAATIDGANGFTQLRKITIPMIRPTIVFVVITSTIGAMQILAEPLLFGSYSVSGGPDRQYQTLSLFIYENFTKLDFGYASAISWMVFVFIVLVAGVNYLLTRRAKGALT
>NC_013595.1|WP_148269767.1|7919081_7919840_-|ABC-transporter-permease-subunit
MLPLYYSIVVASRDNAALADVPPPLLPGGNFFANVARVFDTVPFAMAMVNSVLVSGSVALAVMFFSTLAGFAFAKLRFRGRNALLLLTVATMMVPTQLGIIPLYMLMVKLEWTGTMYALIVPALVNAFGVFFMTQYLSRALPTELLEAGRVDGCTTWGLFWHVVLPAARPAAAVLGMLTFMSVWNDYFWPLVVLTPEDPTVQVALSTLASGYVNDYVLGLAGTTLGTLPLVVVFALLGKQIIGGIMQGAVKG
>NC_013595.1|WP_012893594.1|7917660_7919085_-|beta-glucosidase
MTIVGIRGASITQGRADFPTGFVWGAATASYQIEGAVKEDGRQPSIWDTFSGTPGKVAGGDTGDVACEHYFHYADDVRLMSDLGLHAYRFSVAWPRVQPDGTGPVNPRGLDFYSRLVDKLLEAGITPYATLYHWDLPQSLEDAGGWPERDTAHRFADYARAVHERLGDRVRHWTTLNEPWVSAFLGYGNGVHAPGRKDPAAALRAAHHLLLGHGLATQALRAGGAEEITLVLNLAPVITPAQVGDPAAGPSPADAEAVNRIDTLLTRQFLDPALRGRYPAELLEIVERNGGLAHIRDGDLTTINQPIETIGINYYNPCVVESGPGEAADAAWPGSEDVRFCAVDAPVTAMGWPIVPNGLSRLLVRLADDYPEVGLIVTENGAAFDDVVEDGRVHDTGRTGYLDGHLRAVHAAIAAGADVRGYLVWSLLDNFEWAEGYRRRFGIVHVDFATQRRLLKDSALWYREVIKRNGLRGN
>NC_013595.1|WP_012893593.1|7916664_7917660_-|LacI-family-DNA-binding-transcriptional-regulator
MRRPTLEAVAARAGVSRSTVSRVVNGQTTVTPDIRDVVMRAVNELGYVPNGAARNLVTQRTNSVALVVSEPPNRVFSDDPMFSTVIRSASIELEAVNMQVVLLLAGSQESHARVETYVAGGHVDGVMLVSSHGADPLPVALTRLRVPVVSYGRPAVPVAMPYVDSDNVGGAAAAVRHLLERGRRRIATIAGPLDMIGGQDRLAGYRDVLRDSDRRSIIAVGDFTRESGAVAMRQLLADDPELDAVFAANDLMAIGAMHALRQAGRRIPDDVAVVGYDDIEAARYTDPPLTTIHNPHAEQAAAMVRLLLGLLEGGPADPFIVSTELVVRTSS
>NC_013595.1|WP_148269766.1|7914313_7915687_+|beta-glucosidase
MSAEQSYVLEDSGVLRFPEGFVWGAATAAYQIEGAAREDGRGPSIWDTFSRTPGKVHAGHTGDVACDHYHRYPDDVRLMGDLGLHAYRFSISWPRIQPDGTGPANPRGLDFYDRLVDELHGTGVTPIVTLYHWDLPQPLEDRGGWTNRETAERFAEYAAIVHARLGDRVETWTTLNEPWCSAFLGYASGIHAPGRSEPGLGFAATHHLLLGHGLAVKALRAAGAGRIGITLNLAPVLGDDAEAASIVDGLQNRIFLDPVLRGEYPADVVERAGRFTDWSFVEDGDLEIISQPVDLLGVNYYHPQTVAARPGEPANPVYPGSEGIAFPRPDVPRTAMGWPVQPFGLTDLLVRLSRDYPGTPLIITENGAAFDDVLEDGRVHDAGRVSYLDGHLRAAHAAIEAGADLRGYLVWSLLDNFEWAEGYDKRFGVVHVDYATQNRTPKDSALWYRDVVRRNGL
>NC_013595.1|WP_012893591.1|7912760_7914116_-|carbohydrate-ABC-transporter-substrate-binding-protein
MSLPSRAGRVTLVAGTIGLALAVTACGSTEPKPSASGGGSTSAECAAFSKYGKHDGKTVSIYSPIRDAEADLFQEAWKPFAKCTGMKITYEGTGEFEAQIQVRADGGNPPDIAFFPQPGLLERFAKAGKLKPASAEVKKLTDEGWSPDWAKYSTVDGTFYGAPLGASVKSFVWYSPKMFKEKGWAVPTTWDELMTLSGTIAGSGVKPWCAGIESGDATGWPATDWIEDILLREIGPEGYDDWVGHKLAFNDPKVVAAVDKVGAILKNDKFVNGGYGPVKSIASTAFQEGGVPITQGKCALHRQASFYANFWPEGTKVAEDGDVFAFYLPGNDPSKKPVLGAGEFVAAFTDRPEVQAVQAYLASAEFPNTRMKLGTYVSARKGVDPANAQNPIDKLSIEMLQDPETVFRFDGSDLMPAAVGAGTFWKGMTDWINGKDTKTVLDYIEASWPKS
>NC_013595.1|WP_012893603.1|7927762_7928731_-|hypothetical-protein
MSVTYVGSGPYCYANSLAMVLGGEAPPPAVIEVLTGSPYGMQLIGGSLPLFDSFGWDPEVGLDAAIGLLGWECERVDGGTAAAALDRLRRACQDGPVLAGPLELGLLSYQPGAGKAVGADHYVVVLEVSDNTVLVQDPQGYPYATLAVDAFAAAWHGELISYLERPYRMRHRFTRRERVSPEEALRRSLPAGLAWLAGRTDVEVQPGTLGQAEAAERTADLVEEGLDPEIRMLWQAFAVRVGARRLNDLAACLASLGLDTGAAVAAEQARIVGGLQGPLVAGDDMALAAGLRRLAPTYERLRTTLIADEGTSQAMGTPSRRS
>NC_013595.1|WP_012893604.1|7929960_7930830_+|site-specific-integrase
MAIPRTANPNTHRAYASAVDRVITRLGRDRPLAEVADAEIGTALAELWGASASATWNRNRAAITSWLLWCQTKKHWAVPSVPAEAERRKESVDETRAVAKSTIHRLLSRRDIPLREKTLWRMLYETAARAAEILALNVEDLDLEHRRAPVRSKGSTTEWVYWDRGTAHLLPRLLRLPDDTSRTHGPLFLSERRPVPARRPAAADICPHTGRTRLGYDRARVLLDKYAGLDLHRLRHSAATHLGEAEIPLQLIMGKTRRKNPRTAMRYIKPGAEAIAKVTEVLAPRRRTH
>NC_013595.1|WP_169369445.1|7930893_7931058_+|Tn3-family-transposase
MACNKVNLKRIETHWPDMLRVAGSLITNQVRAYDLLRMFGREGHPTPLGAAFAE
>NC_013595.1|WP_012893605.1|7931711_7932284_-|TetR-family-transcriptional-regulator
MRRNPERRQALIDAAIEVLAREGARGLTFRAVDAEAAVPPGTASNYFANRDDLFTQVGGRIYERLLPDEVTIARSREGVQDQTRYAELMHELVDRVSAFNSGYLALLELRLESTRRPELRAVLTKRIREDIDANIGNHAASGLPGDSTSAVLLYLALNWLIVERLTLPDIFTEQEIHELVDAAVQRSLNA
>NC_013595.1|WP_012893606.1|7932356_7932929_+|dihydrofolate-reductase-family-protein
MRKLVYYIGVSLDGYIAGPNAEFDFYPVSDQMAAWMNDRYPETVPTHVRKLVGLEGVPNKVFDTLVMGRGTYEPALDASITSPYSHLRQYVVSSTLTIDDPTVQVETGDPIELIRRLKAEDTGMDIYLCGGGRLAASLLPEIDEIILKNYPVVAGAGIPMFSGQFRPTLFAPTRRETFDNGAQVTWLTRV
>NC_013595.1|WP_012893607.1|7932945_7933104_+|hypothetical-protein
MHIKFPATITQAKAEYQARSPHRHDQPARDLKPTGRTNLSRRPTAVPRRSGY
>NC_013595.1|WP_012893608.1|7933806_7934661_-|hypothetical-protein
MTNWPERVRRLIAAKRPPREMLKALRADAAKDPEAARDLGHMLLQVSWSETQTDGYGYLPEAEKWLRQAVTKRPQDAEATLLLATLLSTQCGQLWDMALGMRHPKRWDEERKRRAIEACDLYERVLQFDPHSSAAASGLALLRETHSLTGRDHSTVSAAIDLDETESYRFDYFVVRVELLVTNNGDTVTRWVVLRDPEQLWGFEICAWEISEPVAFQYEHGVQVAKHRPARLSGRSLSQVTEEWLDKRDPASRATLLPVGHPVCRDGKILQYGVNGAQMADGPL
>NC_013595.1|WP_012893610.1|7935745_7936018_-|hypothetical-protein
MIMPAARFCRIPVAPDGELRGLSMDVAVAVSALSTALYLHGDVEVLAAARRLVAEVQQVEEKVEPFRRPWVSERTREHFAALVEFLAAAP
>NC_013595.1|WP_081453490.1|7936032_7937388_-|hypothetical-protein
MHKTPQPPSQLSPALAPLWDQILATALAKDPQQRHRDAAAMRQAIETGLAAPTAQAPAPVPPSASAPTARLDTPLPIEPAPTEPAPHASALHAPGSSGLGDRSAPASATRDHVAAVPHRVLSRRRLLTGLGAAGLAAALPAAYYTFTREDTATLRGQPLTGHTGVAVSAVAFSPDGKILAADDGYTVRLWDVATRALLGTPLTGHTSWVSAVAFSPDGKILASGSYDDTVRLWDVATNTPIGRPLAGRNNPTGAVSAVAFSPDGKILATDDDDAVRLWDVVTRTPVGRPLTGYTDSLQSVAFSPDGKILATDDDDAVRLWDVVTRTAIGRPLTGHTSWIAAVAFSPDGKILATGSTDDTVRLWDVATRTPVGRPLTGHTDSLQSVAFSPDGKILATGSDDETVRLWDVATRTPVGRPLTGHTDSLQSVAFSPDGKILATGSDDGTVRLWQL
>NC_013595.1|WP_148269768.1|7938205_7938496_+|tyrosine-type-recombinase/integrase
MTSSCATPRPVSAVFRWHPRLGYDRARVLLDTYAGLDLHQLRHSAATHLGEAEIPLQLIMGKTRHKNPRTAMRYVRPGAEAIAKVTEVLAPLRRRH

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Crispr_ID: NC_013595_46

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_46

8256997-8257112

Orphan

Consensus_repeat	Method
GCCGTACCGGGGTGGAAGGTCAAAAGCGCAGCGAGGGCGGGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_46

>merge|NC_013595|46|8256997-8257112|CRISPRCasFinder
GCCGTACCGGGGTGGAAGGTCAAAAGCGCAGCGAGGGCGGGTGAGGTGGCCGGGGGCCATCCCTTTCGTGCAGGCCGTACCGGGGTGGAAGGTCAAAAGCGCAGCAAGGGCGGGTG

>NC_013595|46|43|8256997-8257112|CRISPRCasFinder
GCCGTACCGGGGTGGAAGGTCAAAAGCGCAGCGAGGGCGGGTG	AGGTGGCCGGGGGCCATCCCTTTCGTGCAG
GCCGTACCGGGGTGGAAGGTCAAAAGCGCAGCAAGGGCGGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_052317109.1\|8248251_8249226_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NC_013595.1\|WP_012893875.1\|8251117_8252467_+\|family-20-glycosylhydrolase	unknown	unknown	gnl\|CDD\|119334
NC_013595.1\|WP_148269788.1\|8243824_8245462_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173874
NC_013595.1\|WP_043653658.1\|8255143_8256184_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043653655.1\|8252892_8254566_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893887.1\|8264274_8265483_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NC_013595.1\|WP_012893872.1\|8247305_8248280_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NC_013595.1\|WP_012893891.1\|8269494_8270238_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NC_013595.1\|WP_012893870.1\|8245462_8246467_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_013595.1\|WP_012893889.1\|8266606_8268232_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NC_013595.1\|WP_148269790.1\|8262258_8263422_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381324
NC_013595.1\|WP_043657558.1\|8263589_8263982_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225557
NC_013595.1\|WP_012893884.1\|8261749_8261941_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893879.1\|8256327_8256873_-\|YciI-family-protein	unknown	unknown	gnl\|CDD\|367663
NC_013595.1\|WP_043657552.1\|8260731_8261652_+\|STM4015-family-protein	unknown	unknown	gnl\|CDD\|238064
NC_013595.1\|WP_012893890.1\|8268231_8269269_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380663
NC_013595.1\|WP_012893871.1\|8246463_8247309_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_013595.1\|WP_012893880.1\|8257699_8258206_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226269
NC_013595.1\|WP_012893874.1\|8249222_8251121_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893888.1\|8265522_8266614_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224093

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_052317109.1\|8248251_8249226_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	8.01183e-111
NC_013595.1\|WP_012893875.1\|8251117_8252467_+\|family-20-glycosylhydrolase	gnl\|CDD\|119334	cd06564, GH20_DspB_LnbB-like, Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)-N-acetylglucosamine), a major component of the extracellular polysaccharide matrix. Lacto-N-biosidase hydrolyzes lacto-N-biose (LNB) type I oligosaccharides at the nonreducing terminus to produce lacto-N-biose as part of the GNB/LNB (galacto-N-biose/lacto-N-biose I) degradation pathway. The lacto-N-biosidase from Bifidobacterium bifidum has this GH20 domain, a carbohydrate binding module 32, and a bacterial immunoglobulin-like domain 2, as well as a YSIRK signal peptide and a G5 membrane anchor at the N and C termini, respectively. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.	3.15626e-91
NC_013595.1\|WP_148269788.1\|8243824_8245462_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173874	cd08509, PBP2_TmCBP_oligosaccharides_like, The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold. This family represents the substrate-binding domain of a cellulose-binding protein from the hyperthermophilic bacterium Thermotoga maritima (TmCBP) and its closest related proteins. TmCBP binds a variety of lengths of beta-1,4-linked glucose oligomers, ranging from two sugar rings (cellobiose) to five (cellopentose). TmCBP is structurally homologous to domains I and III of the ATP-binding cassette (ABC)-type oligopeptide-binding proteins and thus belongs to the type 2 periplasmic binding fold protein (PBP2) superfamily. The type 2 periplasmic binding proteins are soluble ligand-binding components of ABC or tripartite ATP-independent transporters and chemotaxis systems. Members of the PBP2 superfamily function in uptake of a variety of metabolites in bacteria such as amino acids, carbohydrate, ions, and polyamines. Ligands are then transported across the cytoplasmic membrane energized by ATP hydrolysis or electrochemical ion gradient. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	4.74157e-112
NC_013595.1\|WP_012893888.1\|8265522_8266614_-\|ABC-transporter-permease	gnl\|CDD\|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	1.67929e-90
NC_013595.1\|WP_012893890.1\|8268231_8269269_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380663	cd20008, PBP1_ABC_sugar_binding-like, monosaccharide ABC transporter substrate-binding protein such as CUT2. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	1.34751e-103
NC_013595.1\|WP_012893872.1\|8247305_8248280_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.945e-141
NC_013595.1\|WP_012893891.1\|8269494_8270238_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	2.66556e-20
NC_013595.1\|WP_012893870.1\|8245462_8246467_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.81038e-103
NC_013595.1\|WP_012893889.1\|8266606_8268232_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NC_013595.1\|WP_148269790.1\|8262258_8263422_+\|aldo/keto-reductase	gnl\|CDD\|381324	cd19098, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	3.69945e-160
NC_013595.1\|WP_012893880.1\|8257699_8258206_-\|hypothetical-protein	gnl\|CDD\|226269	COG3746, OprP, Phosphate-selective porin [Inorganic ion transport and metabolism].	0.00536469
NC_013595.1\|WP_012893887.1\|8264274_8265483_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.22534e-77
NC_013595.1\|WP_012893879.1\|8256327_8256873_-\|YciI-family-protein	gnl\|CDD\|367663	pfam03795, YCII, YCII-related domain. The majority of proteins in this family consist of a single copy of this domain, though it is also found as a repeat. A strongly conserved histidine and a aspartate suggest that the domain has an enzymatic function. This family also now includes the family formerly known as the DGPF domain (COG3795). Although its function is unknown it is found fused to a sigma-70 factor family domain in CC_1329. Suggesting that this domain plays a role in transcription initiation (Bateman A per. obs.). This domain is named after the most conserved motif in the alignment.	2.50811e-22
NC_013595.1\|WP_043657552.1\|8260731_8261652_+\|STM4015-family-protein	gnl\|CDD\|238064	cd00116, LRR_RI, Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).	0.000171044
NC_013595.1\|WP_012893871.1\|8246463_8247309_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.88878e-62
NC_013595.1\|WP_043657558.1\|8263589_8263982_-\|hypothetical-protein	gnl\|CDD\|225557	COG3012, COG3012, Uncharacterized protein conserved in bacteria [Function unknown].	3.23303e-38

>NC_013595.1|WP_012893879.1|8256327_8256873_-|YciI-family-protein
MEFFCYHRDRPGSATLRDQLVEEHWSYMDRYAAELIARGPTLSPDGETATGSVHIVDLPDLATARAFVFDEPNYQAGVYRDVVLRRWRNVLGRTMWDFPGGKEGGNRYLVLGLGSGQAADLVPADRDELIAYGPLLSDDGTTWLGTALLVRAPDPDAARAVLTPDRYADIEVHDWTFGGRR
>NC_013595.1|WP_043653658.1|8255143_8256184_+|hypothetical-protein
MRRALIAVGVGLSVLGSTVVTQPAQAASVVMVPLSPTVTAAQQVAWFWLADGAANLKNATPYTVQTAVGGERLSTDIVPDGPPASIPPLEGPASPEGEMPTTSGKVFFIGSDLQPHWCTGTAVRSKYRNVVATAGHCLLDTEAPAGPLTKWVFVPGYSEGTAPFGLYVGKQGVAHYDFDDIQDYDRDLAFVNVYRGVVPSSPDVLTNTGMLAENVGGQGVAFNQPLAPTVDVFGYPAGPEPDGSRPYTGETLERSTGSASAMKVTGLPTDRPIGVDSPFTGEGSLGSSWLTQYANDSRTGYLNGITISVSDTDGDNRYDTGVSPYFDGELYTVYQKASNVWTGIIA
>NC_013595.1|WP_043653655.1|8252892_8254566_+|hypothetical-protein
MAAVVVAVVVSLVRDSLDPAWTVVQWYPPSRFADKTSLLAVLGGLLLVGAVNSWMFWQVLQGPADAAPLPRRALWLRRLLYVYVGWLLIPVPLPDEVETAFDVVLWVPIVILFAQVLTRSGPTFRLILVTTALVSTALPSVLEAVRRDSYAGWAAPVLSAVSMALVAAGLVWFLMILIAQRRDGRWTRTTMVLGACQLAVIPITVVLNQLVDFPESVVLSDLLDVLVVFQLVWLARTAHELNRPSTAPDPEPLRSPRWLLALMVLAPMAVIAPEAKPHMTYTWLDADCSSIPLFADTPPQDRRRVYLCLAGNGRLYENIRFWSAGGRPVADQQLLGKGWKSCAAGDGRVRAEALVYLCPEVVARDRPDLLLTAAQLKQRDAEERARRRQEVADEAAQYVSGCRDPWPALRTSRQVTAVHLPTDWDGYYIFDGRAASLEALYGENIESDSPLVAHGGAAMVSTTLEYGATCVTVKVLRTAPPIRRKGWDDVVDADLVLGSGRMHLKGRGIKVEVALPKAGKYRVRLHTRTLDEGVGEDLVVVFPTSRQGLVRQPSPTG
>NC_013595.1|WP_012893875.1|8251117_8252467_+|family-20-glycosylhydrolase
MNERPEVVPALQEWTGGTGEFRLGPESRVVCADERLGSRLAGELGIGHATEGPGDVVLEIVPSGGRAEGYRIEAAPGRVTITAPTARGLFYGTRTLVQILRTGAVPCGVAHDWPDYPVRGYMLDVGRRYVTPELIHRLVRLMGRYKLNELQLHLNDNEIKAPDGDWGKALHGFRLRSPAFPGLAPEESYSRDDWDGFEELAAAHAITLVPEIDAPAHSRAFISFDPSVGHDGGDSDHLDLANPAATELVKAVFTEFVPWFRGPAVHFGADEYYQSKALWKQFFNNMAAHVRSLGKQPRAWGGFTRLSPTGDTAGFDPDVVINSWNNGFYGPEGAREDSYALINSNDDLLYIVPEADYYHGAGLDAEWLYDHWEPHVFADGQSLDPGDPRLLGAMPALWNDLVRADYTEERMYELIEHSLGVLAQKMWSGAKAGLPYRDFVRLLQRLDSW
>NC_013595.1|WP_012893874.1|8249222_8251121_+|hypothetical-protein
MTYHLRYQVLPGRDAAPLARYCAEHGIPEVVLIYNSEELHSGHPTGADEDLWFEHVAAVKRVLDAHGVGAGLNPWVTVGHADRGRMQDRGFAPMVSPSGQVSTATASFACPVWRTWLADHYGRFAELDFRVLWLEDDFRFHNHSPLTWGGGFEPEMLERFARLSGRRVEREELVTAITAPGSPHPWRALLQRTWREAQLDALDQVRQAVAGRAKLGLMSSGLGVASVEGRDWAALFDRIEVHRPHFAAYRDEPGEALAYSIAMLELQRPLRPAAVEVAPEIENWPHTEWTKSDTQTWSEMVTARLSGADGLLLDVHPFVTGEPARYPRIGTMLDRSRAALDATASPGLRTTGVTVPWWPDTAARIPGDGTFGGLAADPLRAARYLLPYGVPIQAGAGAVTAVFGTIAWGVPDSEVETLLSGGVLLDGHAAMILTERGYGSLLGVTVEEVAHRSTPSRYPYSMERIADGGELLSVNVQEAVARLAAASGAEVWTRILTPRQEHWGDGRVAFVNELGGRVVTLAACAPERLGRCDDGRRLAHRAISFLGGDFPLVTGGPHLMPQFATVNGRRRLAIVNGSADPARPVVSGVRPEKATLLAPLEEPRPVPVREESGYFVIDADVPHRGYVIVEYA
>NC_013595.1|WP_052317109.1|8248251_8249226_+|ABC-transporter-ATP-binding-protein
MTERGRPMPEETPVLAAEDVTKHFDTGRQTVRALENVTLRLYRGRIAALVGESGSGKTTLARLLAQFYPVTSGEIRLRGEVVSRPDKDFYGEVQLVFQDPFASLNSLRKVEHNVRRALKLHGHPADDAAVHELLAKVNLSPAAEFARKLPHELSGGQRQRVAIARALAVRPSVLLGDEPISMLDVSIRLDVLNLLARLREEEGLALLYITHDIASARYLSDDIYVMYAGQMVEGGPAESVIQEPKHPYTQLLLDSSPDPERAGGSSAFTATAKLGEPPSLVDPPPGCRFHPRCPFAKEQCKTSFPPRTEFADGSWTNCWLHNES
>NC_013595.1|WP_012893872.1|8247305_8248280_+|ABC-transporter-ATP-binding-protein
MILDVKGLNVDYITAKGAVRAVNDVSFQLRRGEILGVAGESGCGKSTLIMALIRLLRPPAAITGGQVWLHPREGEPVDIASRTDRELRRLRWRSMAVVLQSAMDALNPVARLSAQFADVLRAHGYKNTEERTAELLEMVGISPDRARSYPHEMSGGMRQRAMIALALACDPELVVMDEPTTAVDVVMQRQILAQILELRERLGFSVVFVTHDLSLLVELADRIAIMYGGRIVELGEAAEIYRAPKHPYTKGLRDSFPPLHAPVTRLDGIPGTPPDLRNLPTGCAFEPRCPRRFADCTERRPELLAVGDALAACHLHDRERTAHA
>NC_013595.1|WP_012893871.1|8246463_8247309_+|ABC-transporter-permease
MKVRIGIGIIAFFSVIAIIGPWLNDLMGIGPWKIDYNAISEPPGAGHLLGTTSQGTDVLAQMIAGTRNSMVVGSVAGVIGVILAVVVGVTAGFFGGKVDAVLSFVTNMFLVLPVLPLTLIVAGYVQDTGPVTIALIIGLFGWAAGARTLRAQTLSLRGRDFVMAMRMIGESKPRMIFVEVLPHLAGWISAMFLHLVLGAVLAEAGLAFLGVSSADTISWGTVIDQARQVALLNGMWWWFVPPGLCIALLGTATGLVNFGIDEVMNPRLRTADIKAMRKALA
>NC_013595.1|WP_012893870.1|8245462_8246467_+|ABC-transporter-permease
MKQGRWRFLTKRVAFYLATSWSAITLNFLIPRLMPGDPSSVIVRQLQRQSGESVSPEAVAAIQKLFGDPRAGLLQQYWDYLVSIARLDFGLSVSRFPTPVGELLADGLPWTLMLVGATTVVAFVLGTGLGIAAGWKPGGRLDGFLSPLSTFLTAVPYFWVALIALYVFGLVLGWFPLGGGYDPDLYGRPGFLGSVLQYMVMPAATIVFSAFGGWLLGMRNMMITTVSEDYVLLGKAKGLSAGRVMFRYAARNALLPSVTGFAMAIGGVLGGALLTEIVFSYPGIGYLLYDAVSKRDYPLMQGVFLLTTLTVLLANFVADSVYVMIDPRTREAGR
>NC_013595.1|WP_148269788.1|8243824_8245462_+|ABC-transporter-substrate-binding-protein
MTACSPGTSGGARETTTNAAGGTSDSISLRINNATTYSRNFNIYSPSTDIAPQISLIYEPLVRRNVLKGGRLEPWLAESWEWSDGDKTVTLKLRTDVKFSDGTPMTSKDVAFTLNISLEHPELNTGGQTYVSAEATDDHTVVVKWKKPAQLDFYRFALGVTGFAPRIVPEHIWKDKDLKTWTNPDPIGTGVGKLTQFTPQQFTLETRADYWGGQFPMKSIKIVATGGDDQTKARLLKGDIDYATISWPNAEQEYMARNPKANVYKTFHTGGEESLLFNLAKEPFSDVNVRKALAMSVERASVLKLAPTGQEPANACGLEPQVYAEFMAPECKPQPLDVEGAKKALADGGWTVEGGRLAKDGKTYPLSIKVVQEYANWMAYGKGMQDQWKSNLGLDVKVMAIPEENYDPQLNEGDYDMALYWTGNSNGLYSVFADQLDSDKYKPIGKDAQYQNQSRWKDTSTTPLLDRLRDTVGDPAAQTEAGYQLQKVVLDQVPFSPMFTADWFVEMNQSRWVGWPETGETDHVPHSALGPDIVMTLKGLKPAGK
>NC_013595.1|WP_012893880.1|8257699_8258206_-|hypothetical-protein
MLARSKPSAVLSMLGILGALALATAAPAGAAPVTAAPAAAVVETELGITVYAHDIDEEGTWSNGDEVFIKVVRNGASQRFAPTDGTVDVNEDEEGQIVEFPSHYPLKFSPGEKVTVQVWEDDTAGDDLLAEAKDVIVECNRPFSGVTEISKRKYYHYSFEAKFSAFGC
>NC_013595.1|WP_043657552.1|8260731_8261652_+|STM4015-family-protein
MAGAHRETYAGLPVAEPHVIVHHRSPDPWRFAWPLYDGDPDRENDDGSGFAAGLEELLGTVDGSRIQAIVVAGSGAPNAPAMLAANAHRLPRLRSLFLGFVEPEHWEISWIQQGDVTPVLEAFPRLERLDVRGSEGLRLRPVRHASLKVLRFESGGLPGHVVRAVGESELPGLEHLEMWLGVSQYGGDATVGDLQGILSGSGLPALRRLGLRDSEIQDEVAAAVASAPVVARLEALSLSMGALTDTGAESLLSGQPLTHLRHLDLHHHFLTDDMAARVRLALPGVEVDLSEPQPSLEEWRYVAVSE
>NC_013595.1|WP_012893884.1|8261749_8261941_-|hypothetical-protein
MVHEPGDQVHEYVVEQVRDVTRGGKIVFEVPGGGVDTGLRRLIPVTYDIVLDHPEVRETGEDR
>NC_013595.1|WP_148269790.1|8262258_8263422_+|aldo/keto-reductase
MGPTRSRPSAGCCSTCSPRPPTTSPGCRKPGTAPPRRTPPGRPAGRPCRDPAAAEDSSQVGYVVGVQALVQRPLGRTHLTVTRLGLGLAALGRPAYITLGREEDLGDDRGVAAMRARTWAVLDAAWARGVRYFDTARSYGRAEEFLAGWLRERGIAPGAATTGSKWGYAYVGGWRMDAEHHEVKELSAERLRRQLDQTRELLGEHLSLYQIHSATVESGVLEDEGVLGRLRALRAEGVAIGLSTTGPRQADTIARAVEIGTFDTVQSTWNLLERSAGGALSRAHGAGMGVIVKEGVANGRLTARAAPAPLAAAARDRGVTPDALALAAVLARPWAGVVLSGAVSVEQLHSNLGAAEVGWDADLDERLAGLAEDPETYWAGRGALAWA
>NC_013595.1|WP_043657558.1|8263589_8263982_-|hypothetical-protein
MSRRVPATAGCLCGLPAPYQDCCARFHRGEGSASTAELLMRSRFSAFGVGDEAYLLRTWHPADRPPRVELDKKLRWVRLEILETADGSVFHNEGTVRFRAHYLDRGQPGQMEEHSRFVRLDGRWVYAGVV
>NC_013595.1|WP_012893887.1|8264274_8265483_+|cytochrome-P450
MDDQNTDHTGHADDLPRLPFTRDDPLEVPEMYRALRAVRPVTRVRTQAGDLAWLVSGYEEARQAFADPRLGRSAPDPERAARISGSVLLGGPRGDIETEKAEHERMRRMLAPAFSARRMSALGPHVQQLVDELLDHMAELPRPVDLREEFSVPLPVLVICELLGVPYGDRGHFRKLAEAMTDLSDPRRAEAAMTELADYTRAILIDKRADPADDVFSDMATMEAPDEEIATLAAGLLFAGHETTVNRIDYGVLLLLGNPAQRDALVADPSLTAPAVEEILRMAAPGNHGLPRYAHEDVSIGGVTIRRGEAVLIVTTAANRDERTFPEPDRFDIGRPLGDPQLAFGYAARYCIGASLARVELRSVFGTLFRRFPTLELAVPAEELVERETSLTGGFTRIPVTW
>NC_013595.1|WP_012893888.1|8265522_8266614_-|ABC-transporter-permease
MPKLIWREPIATTTITSRQPTGEELGPDAVPRAREPEPEPKGEAPRRVVTLGDIAGRESGGLVVLLVAVGILTLASDEFLTGNNLANLARQVAIFGIIAVGQLLVILTAGIDLSVGSVLGLSGASTAQFLVAGMPIWPALLLGVGIGTVLGIVNGLLVTRALLPPFIATLGMLGIARGIVLVTTDAQTVQGLPAGFQAIANGTILGIPNLLIVAALVTGVMWFVLSRTVFGRYIYAVGSNPESARLAGVPVRMVTISVYAISGLLAGLGGVLLASRLGAGIPTAGTGFELNAIAACVIGGASLFGAKGSAIGAATGALIMGVLNNGGNLLAINAFYLQIAIGVLILVAVGFDQLNTRRSATAG
>NC_013595.1|WP_012893889.1|8266606_8268232_-|sugar-ABC-transporter-ATP-binding-protein
MKAKEPVVELRDVSKAFGPVQALTDVSLRLIPGQVNCLAGENGAGKSTLIRVLTGALRRDSGSYVIDGRSVTSPTPASVRAAGVQAVYQELSLLPHLSVAENLFMGRLPARTGVIARGRLRARAREALDEVGLTDLSPDAIVERLPAATRQLVEIAKVLTADSVKVVVFDEPTTALTEAESARLLEYILRLRERGIAMLYVTHRLEEMFEIGDWVTVLRDGSLSEAGPISDYDEDRLITAMVGREISSLYPETHRHAGTPALRVRGLRRSQDSPSIDLEVGTGEILGIGGLLGSGRSELLLSIFGADPIVAGELEVAGKPVKPSGPRTMMNAGVGLLTEDRKVLGLLPELSIRENVTIASLRSGSRHGLLPAREQAEEADRLLDSLRLRAGSYDQPVSTLSGGNQQKVLLARWLLTKPKVLIFDEPTKGIDVGAKGELYTVIGDLAAKGLGIIVVSSYLPELLGLADRILVLRDGRVAGELPGTATEEDVLRLASGGGRAAESVLQEEIPAPREGAPASSEGAGATIPPTPDDPGEVSRDA
>NC_013595.1|WP_012893890.1|8268231_8269269_-|ABC-transporter-substrate-binding-protein
MARSRIVFSLSLVAAIALVALVLGVVGGRATSSASQSAGGGMAGAASGKKIDVIIKASDSSFWQTMIAGAKQSGGDFGLKVSTFGPTSETNIDQQVQLVENSISRGVDGLVIAPNSSSALNSAIERARKAGLKVITVDSRVTTASEGFIGTDNLKAGMQAGKRMCELLKAQNKTSGSVMIESSVAGIQSLVDRDSGFKQGLANNCPQVKVTLQRYNNNDINTAASQVNDALTANRELAGVFADNNTSGVGAARAIQDNNVTDTVPVVAFDSDPQENAALAAGTIDALVVQNPYFFGYQGVLAAGMAAAGRIPPRDIDPGAVVADKRNMNDPDVKLLLNPPTMKAE
>NC_013595.1|WP_012893891.1|8269494_8270238_-|FadR-family-transcriptional-regulator
MTPGSPLTALRAPALAGIRRLNALDTVRARIAMAVDLGLLQPGERLPPTGEIARALDVGEMTARRALVALCEEGMLERRRGRTGGTLVAPRPAGGRVREIAAYQAAAGDVHRLIDQRLLLECGTAHLAASNAARHQIGELEALVARMDQASDWAEFHTWDERFHMTVAAATGLPSAAEQYGLVLRELYRHYLPCPLSHLRESNCEHAELVTALADRDPLKAAEVARGHVEALRRTMFVGLAEHGRDA

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Crispr_ID: NC_013595_47

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_47

8334766-8334845

Orphan

Consensus_repeat	Method
CACCACAGGAAGCCGCACCCCCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_47

>merge|NC_013595|47|8334766-8334845|CRISPRCasFinder
CGCCACACATACCGGCGCCCCCTCCCGCCAGGGCGCCCACCACAGGAAGCCGCACCCCCACCGCACGCCCGCCCCCCTCC

>NC_013595|47|44|8334766-8334845|CRISPRCasFinder
CGCCACACATACCGGCGCCCCCTCC	CGCCAGGGCGCCCACCACAGGAAGCCGCAC
CCCCACCGCACGCCCGCCCCCCTCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_169369467.1\|8334988_8335600_-\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319790
NC_013595.1\|WP_012893938.1\|8325798_8327409_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_013595.1\|WP_012893939.1\|8327569_8328478_+\|hydrolase	unknown	unknown	gnl\|CDD\|226708
NC_013595.1\|WP_012893941.1\|8329465_8329684_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_052317112.1\|8337733_8338234_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NC_013595.1\|WP_012893944.1\|8331293_8331623_+\|isoamylase-early-set-domain-containing-protein	unknown	unknown	gnl\|CDD\|199892
NC_013595.1\|WP_169369465.1\|8334356_8334701_+\|anti-sigma-factor-antagonist	unknown	unknown	gnl\|CDD\|132914
NC_013595.1\|WP_012893937.1\|8325044_8325659_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NC_013595.1\|WP_043653673.1\|8332315_8333428_-\|acetate/propionate-family-kinase	unknown	unknown	gnl\|CDD\|234680
NC_013595.1\|WP_012893940.1\|8328680_8329364_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893950.1\|8335925_8336435_+\|SRPBCC-domain-containing-protein	unknown	unknown	gnl\|CDD\|176864
NC_013595.1\|WP_012893943.1\|8330293_8330923_-\|uridine-kinase	unknown	unknown	gnl\|CDD\|180660
NC_013595.1\|WP_012893956.1\|8342171_8342654_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_013595.1\|WP_012893952.1\|8337269_8337542_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893957.1\|8342842_8343085_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012893954.1\|8338618_8341774_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|223715
NC_013595.1\|WP_012893945.1\|8331816_8332266_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369297
NC_013595.1\|WP_012893951.1\|8336434_8337028_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_013595.1\|WP_012893953.1\|8338226_8338553_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_013595.1\|WP_012893955.1\|8341786_8342005_-\|EF-hand-domain-containing-protein	unknown	unknown	gnl\|CDD\|238008

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_169369467.1\|8334988_8335600_-\|HAD-IA-family-hydrolase	gnl\|CDD\|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.2414e-24
NC_013595.1\|WP_012893938.1\|8325798_8327409_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	1.49896e-155
NC_013595.1\|WP_012893939.1\|8327569_8328478_+\|hydrolase	gnl\|CDD\|226708	COG4257, Vgb, Streptogramin lyase [Defense mechanisms].	7.96201e-28
NC_013595.1\|WP_052317112.1\|8337733_8338234_-\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	4.14765e-14
NC_013595.1\|WP_012893944.1\|8331293_8331623_+\|isoamylase-early-set-domain-containing-protein	gnl\|CDD\|199892	cd07184, E_set_Isoamylase_like_N, N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins. E or "early" set domains are associated with the catalytic domain of isoamylase-like proteins at the N-terminal end. Isoamylase is one of the starch-debranching enzymes that catalyze the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen. Isoamylase contains a bound calcium ion, but this is not in the same position as the conserved calcium ion that has been reported in other alpha-amylase family enzymes. The N-terminal domain of isoamylase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and the beta subunit of AMP-activated protein kinase.	5.79483e-35
NC_013595.1\|WP_169369465.1\|8334356_8334701_+\|anti-sigma-factor-antagonist	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	3.47616e-22
NC_013595.1\|WP_012893937.1\|8325044_8325659_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	8.77166e-25
NC_013595.1\|WP_043653673.1\|8332315_8333428_-\|acetate/propionate-family-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	8.51339e-138
NC_013595.1\|WP_012893951.1\|8336434_8337028_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	7.4489e-08
NC_013595.1\|WP_012893950.1\|8335925_8336435_+\|SRPBCC-domain-containing-protein	gnl\|CDD\|176864	cd07822, SRPBCC_4, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	2.10023e-47
NC_013595.1\|WP_012893943.1\|8330293_8330923_-\|uridine-kinase	gnl\|CDD\|180660	PRK06696, PRK06696, uridine kinase; Validated.	1.17736e-27
NC_013595.1\|WP_012893956.1\|8342171_8342654_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	9.83284e-15
NC_013595.1\|WP_012893954.1\|8338618_8341774_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.81762e-50
NC_013595.1\|WP_012893945.1\|8331816_8332266_-\|hypothetical-protein	gnl\|CDD\|369297	pfam07274, DUF1440, Protein of unknown function (DUF1440). This family contains a number of bacterial proteins of unknown function approximately 180 residues long. These are possibly integral membrane proteins.	5.92491e-07
NC_013595.1\|WP_012893953.1\|8338226_8338553_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.78933e-19
NC_013595.1\|WP_012893955.1\|8341786_8342005_-\|EF-hand-domain-containing-protein	gnl\|CDD\|238008	cd00051, EFh, EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.	1.80589e-11

>NC_013595.1|WP_169369465.1|8334356_8334701_+|anti-sigma-factor-antagonist
MSDHSQFSVVSLIGDLDKLSAPQFEEALAGLLTQGRVRIIIDTAGLGFCDSTGVWALLTTMRRAYEQNGWLRLAGVHGFLGRLLELTRLGEAFPIDPDVGESLRQASAGSVSAS
>NC_013595.1|WP_043653673.1|8332315_8333428_-|acetate/propionate-family-kinase
MGTTDPAVLTVNAGSSSLQLHLVRNGRVLRAEQSEKSPDPAGVERTLSDFLDAEPGCEVVAAGHRLVHGGDAVRQPTVVDDAVLAAVREHADLAPLHVPPALALVEACRRRLPDIPHVLCPDTAFHAGLPERAATYALPPEWRSRYGLRRYGFHGLSYAWTLRRAAELLGRPAGALHLVLTHLGGGASVCAVREGRSVDTSMGFTPLEGVPMSKRSGSVDPGMLLWLLSGSRLSLEELRDGLEHRSGLLGLSDGRSGDTRDLVSAGDHASALALEVFVHRVSREIAAAATSLDRLDALVFTGEIGWDQPEVREAVCRRLALLGVEPPALADPEADGAVSRPDAAVPVLVVRPREELQLARDTLGALGDIP
>NC_013595.1|WP_012893945.1|8331816_8332266_-|hypothetical-protein
MTRDLVNGAAGGVLATAAMSAVMLAGDRMGLMPDQPPKRIARAVLPGHRHRPKPGEGVLGAVTHFGFGAACGALYALARGRRRTPILLGAGYGLAIWLVSYQGWVPRLGILPPISGDRPGRPAVMAAGHVVYGTVLALAVNRLNGAAET
>NC_013595.1|WP_012893944.1|8331293_8331623_+|isoamylase-early-set-domain-containing-protein
MIKRGKPTKNGQVKLTFTVPADQPLGGISLVGDFNNWDPYAHPMQRKDNGTYQVSLTVPSQQPIRFRYLADGGVWFDDADADHHDEHGGRINPVLRQDLAGEGIPAPVM
>NC_013595.1|WP_012893943.1|8330293_8330923_-|uridine-kinase
MEIRPISPSLLVEELADRVASAAPDSWVRVALDGAPAADPGRLADALVDPLRLRGREVLRVSSADFLRPASLRFEYGRTDPDAFYTDWLDYGALTREVLGPLDPGRSGKVLPTLWDSAVDRATRAPYVTVPRGGVLLLDGALLLGQGLPFDLAVHLWLSPGALSRRTAGEWRWTLPAYARYEREIEPVGVADVVVRVDDPRHPAIVRRP
>NC_013595.1|WP_012893941.1|8329465_8329684_+|hypothetical-protein
MSIQEELHQVEKELARLRAEAAELRRQVGEIGPTDAAERSTLITMADQQEALADELEGRRQALLQQAGDPDT
>NC_013595.1|WP_012893940.1|8328680_8329364_+|hypothetical-protein
MKRILLILAILAPVLALAAPARAGGWAVTYMDPAPADMRPHTTYTLGFWLLQHGTHPYEGDDLGEVGLKFTDGKRTVGFPGVELREPSHYAAAISLPPGTWKVEGVQGWFAPYAIGTLSVPGSLKVDPIPKDLQRAIDDQAPQKDHWGEIHPPGFPAGTASPSPSTSPAASPAASPAVSPSAGAAGAPGTTTVAVVEPDSWWRPPYTVAAVLALVALGVVAHRVRRR
>NC_013595.1|WP_012893939.1|8327569_8328478_+|hydrolase
MSPDLTVSIEELPVSGRDAGPYGITTGPDGALWFTMVHHGRIGRMTPGGELTSHQLDPASCGPTVIASGPDGALWFTEYQSHRIGRITTAGEIGSFALPSPDAGPFGIAAGADGAMWFTETNAGRIGRITTGGEVTEFPLPVPGAFPSAIAAGPDGAMWFTMNQADAIGRIGLDGDVTVHPLPTAGAAPVGITAGADGAMWFVEIGAGRIGRITTGGRIDEFPLPDRGARPHAIAVDGHGDCWFTEWGANRVGRITPDGRIDGYGLPTPASEPHGIAAGPDGTIWVALEIGALARLTPSGPR
>NC_013595.1|WP_012893938.1|8325798_8327409_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MFRRPVLSTQLTLRGVSKAYGEQPVLDHVSLTVRPGERAGIVGENGSGKSTLLRLIAGIERADDGEVTVSADGGIGHLGQTIGLPADQTVQHAVDAALAELRAMERRMRALEDDLTEDRLAEYGDLLSAYEARGGYEADARVDKALHGLGLGHVGRDRPLGSLSGGEQARLGLACLLAASPEILLLDEPTNHLDGASTAWLEERLRAHRGTVVAVSHDRVFLDRVATSILEVEDGGITRFGGGYSGFLAEQAAARRRWEQAYADWCEEIGRLETFAATTAHRVAHGRDIKDGNKMAYDRHGGRVQSSVAGRVRQAQERLRRLQDDPVPRPPEPLRFGGLFRRGTADGPVAELRAVRVGDRLAVDSLTVEPGQRLLVHGPNGAGKSTLLRVLAGELGPDGGTVRHRGRIGYLPQESPPGRPGRSVLDAFADGRPGYPEEHRARLLSMGLFRPDSLRTPVGALSVGQRRRLALARLLAGEADLLLLDEPTNHLSLTLVEELEEALDAYRGALVVVSHDRALRGRFAGTEIEMRDGRPA
>NC_013595.1|WP_012893937.1|8325044_8325659_-|TetR/AcrR-family-transcriptional-regulator
MSTGNVRPGGRTARVREAVREATLAELADKGYEGLTVEGVALRSGVHKTTVYRRWGSVEGLAADALDLAGGEPWPIPDTGTIEGDLRELAHLVLTGFADPEMGPVSTAFISASGRNPVVARALHAFFAARHEQSAILVVRAVERGELPEDTDAADVVRTAVAPLYYRLFVSGEPVDTAVADRAADAALAAARAGVFRTVGPGHA
>NC_013595.1|WP_169369467.1|8334988_8335600_-|HAD-IA-family-hydrolase
MTAFRPTDQEEAVTGWMLLDYGEVISLPQPAEEVAAMAVLAGQDPDAFRDRYWHHRDPYDRGQAPHLYWSNVLGRDLAADDPVVTDLNAADVASWSHLDPAGMDMLQELAGRHRLALLSNAPEPLAAAIDEAPWAAMFAHRFYSCRLALAKPDAAIFERVLHHLDADPGQITFLDDRAVNVHAAAALGINAVLYRAQPHAQGR
>NC_013595.1|WP_012893950.1|8335925_8336435_+|SRPBCC-domain-containing-protein
MVKRILLVVVALLVAVPAGLYTWTRIAPHQVRAEVEIDASPERVWQVLTDFGAYPQWNPFIVSAVGEARVGAVLTNRLSDEGSVTTFTPTVLAATPGRELRWIGRFGVPGIVDGEHYFRIEDLGGGRSRLTQGETFTGALVPLAGGALDVADNFAAMNTALKARAEKMP
>NC_013595.1|WP_012893951.1|8336434_8337028_+|TetR/AcrR-family-transcriptional-regulator
MSTAPELSPLTPRAAEIVSAARVLLEEEGRDALTVRALADRLGIRAPSLYKHFSDKAAVEAALMERGLAETGAALHAALDAALHSTPAEDPIGAVLRAYRRIGLAHPNLYRLTTSGPLPRQRLAPGLEEWAGTPFFLAAGEPYLAQALWSFAHGMVILELDGRYPEGSDLDRTWSEGAHAFAARHLRVERPGTEAQG
>NC_013595.1|WP_012893952.1|8337269_8337542_+|hypothetical-protein
MSRIRITMDNAALRDVAMRTAAGKRPQFDARTTQVLQRVSASHGGGPVDEVDEALRAALLQLPGIQQFDGAQIRRWATRISERQDPLTES
>NC_013595.1|WP_052317112.1|8337733_8338234_-|ATP-binding-protein
MAEAAHEGVRLVPESPEAVRTDQESPEAAQAPPEDGAAADGGRTLSLPIAGDLAGLRRLARRFLEPEVLDEMREKNFILAVSEAANNVLDHAGTGGTIILRRDADRIVAEIRDRAGLLTDAEAGMTPPPVGSRRGYGLWLMRQMCDGVEILHDPAGSTVRLTILRA
>NC_013595.1|WP_012893953.1|8338226_8338553_-|STAS-domain-containing-protein
MGIHLEGRMDPDGSRVIIPIGDLDRDAADTLATAVNESLAHPPGRLVIQMTHVQFCDSSGIVTLLDAHADAAQLGTELVLAGVSDHLRALFQICALDQVVRIVEESRG
>NC_013595.1|WP_012893954.1|8338618_8341774_+|SpoIIE-family-protein-phosphatase
MQKETPSSGGEMGSRIRGHDWGTTPLGPMEQWPAPLRGAVDLALSAGMQIVVFWGPDYIPLYNDPYIPTIGDKHPAALGHPAVENWRETWDVLRPLLDGVRETGEPFWARDHPFLLVRHGFLEQTYFDISYSPIRLADGTVGGVLCLVSETTGRVLAERRLRTLSQVGVAASGTVTRQEVARAVVSVLGEARDDVPFALVYLLDADGDLRLAVPHGTAPARIRAGGDLQRSMTGGGSAPELSGEPFGASGPAVALVLTSGARVLGVLVCGTNPLLQPRGPYQEFFEVLTAGVSRALSAAEAHEHERRRTRELAELDDAKTAFFSNISHELRTPLALILGPLQELLDDPSLGSDQHTVLRTARRNAMRLLTLVNDVLDFTSVDSGRTRARYQPTDLTAQTAELAGVFRSSMESVGLTLRVEGEPLPEPVHLDRHMWERIVFNLLSNALKHTFAGGVTVGVRPGEGHAVVTVSDTGVGIPGHEIPNLFERFHRVSGSPSRSHEGTGIGLALARELIALHGGRIEADSRLGEGTTFTITLPYGSAHLPQDQVADAAMPYGTGPGEGLWLPIPDERAGRGATNGAAPEHSAGRSAVERILVVDDNADLREYLVRLLSPHWAVTAVADGAAALDAAREQNPDLIIADVMMPGMDGLELVRRLRADPGTRSMSIMLLSARAGKEESLTGLTAGADEYLVKPFSARELLTRVRGVLRLAAARSRHNRQLRELTEAALAINEAPSAPEVLALTEKYGRLLADSPGARVTLASGSDLRVEPPSAAVSAVSGVSGIAADGRDDTVLRQLAQLTAARLENLKQLELEHRIATTLQLALLPEVPRISGAEIVGRYRPGNDESSVGGDWYDVIRVSGDEVVLVIGDIVGKGVKAAATMGRMRNALRAYALEDPDPGRILGRLNRMTTGRYDRMHGTVLCVRLSLSTGRLQYSSAGHPPVLICRADGEADYLGGALAPLVGALPSTVFTTAETRLEPGDRLLLYTDGIVEKRSADILAGMARLRSEMVKAAGLDLDAQLESLLALVGDEDTRDDVALLGFALAGV
>NC_013595.1|WP_012893955.1|8341786_8342005_-|EF-hand-domain-containing-protein
MSTEPTGERLAELKQAFAAIDADGDGFITEREFGERFPDLPAEAIGSLNRDADSDGDGRFSFEEFVRIVSVD
>NC_013595.1|WP_012893956.1|8342171_8342654_+|GNAT-family-N-acetyltransferase
MIRPATPDDVPAIIDMIRGLAEYEKALDEVETTAEQLHDALFGPSPAVFCHIATDGETVAGFALWFVSYSTWLGRHGIHLEDLYVHPGHRGAGHGKQLLVELARICVERGYGRFEWAVLDWNTPSIEFYRSLGAEPLDEWDTYRLTGPALEKLAATEHPR
>NC_013595.1|WP_012893957.1|8342842_8343085_+|hypothetical-protein
MADLDREAMRAVLERIQRLSDEHWWALDPSCRLMEGDAWVGPTGARFGTQVNADQRELRDLLARAVHSAQSRLASLPGTS

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Crispr_ID: NC_013595_48

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_48

8471300-8471457

Orphan

Consensus_repeat	Method
CCGCCGCGCACCCCCACCCCGACTCC	CRISPRCasFinder

3 spacers

DEDDh

The CRISPR arrays of NC_013595_48

>merge|NC_013595|48|8471300-8471457|CRISPRCasFinder
CGGCCCCCCTCCCCCGCACCGTCCCCGGAGCCGACGCCCACCTCCACACCGCCGCGCACCCCCACCCCGACTCCCACACCCCCGCGCACCCCCACTCCCACTCCGACTCCGACTCCCACGCCCAGTCCGCCGCGCACCCCCACCCCCACTCCGACTCC

>NC_013595|48|45|8471300-8471457|CRISPRCasFinder
CGGCCCCCCTCCCCCGCACCGTCCCC	GGAGCCGACGCCCACCTCCACA
CCGCCGCGCACCCCCACCCCGACTCC	CACACCCCCGCGCACC
CCCACTCCCACTCCGACTCCGACTCC	CACGCCCAGTCCGCCG
CGCACCCCCACCCCCACTCCGACTCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012894072.1\|8467792_8469283_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NC_013595.1\|WP_012894082.1\|8481281_8481662_-\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274712
NC_013595.1\|WP_052317117.1\|8457506_8458556_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366944
NC_013595.1\|WP_012894071.1\|8466733_8467783_-\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NC_013595.1\|WP_012894079.1\|8477805_8479107_-\|L-lysine-6-transaminase	unknown	unknown	gnl\|CDD\|236224
NC_013595.1\|WP_012894073.1\|8469350_8469995_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|378988
NC_013595.1\|WP_148269316.1\|8458578_8459205_-\|RICIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|379501
NC_013595.1\|WP_012894065.1\|8456127_8457288_+\|DegT/DnrJ/EryC1/StrS-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223476
NC_013595.1\|WP_012894076.1\|8473877_8475284_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270875
NC_013595.1\|WP_012894075.1\|8472138_8473857_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_052317118.1\|8465028_8465427_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377913
NC_013595.1\|WP_148269798.1\|8479950_8481123_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|349882
NC_013595.1\|WP_031167083.1\|8477534_8477789_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_013595.1\|WP_012894083.1\|8481672_8482347_-\|hemolysin-III-family-protein	unknown	unknown	gnl\|CDD\|224191
NC_013595.1\|WP_012894070.1\|8465634_8466591_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235737
NC_013595.1\|WP_012894078.1\|8476624_8477227_+\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429
NC_013595.1\|WP_012894069.1\|8461633_8465032_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|366154
NC_013595.1\|WP_148269317.1\|8460174_8460954_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239492
NC_013595.1\|WP_043653718.1\|8475342_8476602_+\|DUF2510-domain-containing-protein	unknown	unknown	gnl\|CDD\|236090
NC_013595.1\|WP_012894080.1\|8479251_8479809_-\|HdeD-family-acid-resistance-protein	unknown	unknown	gnl\|CDD\|225786

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012894072.1\|8467792_8469283_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	6.35371e-118
NC_013595.1\|WP_012894082.1\|8481281_8481662_-\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274712	TIGR03666, Rv2061_F420, PPOX class probable F420-dependent enzyme, Rv2061 family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity].	3.28746e-49
NC_013595.1\|WP_052317117.1\|8457506_8458556_+\|hypothetical-protein	gnl\|CDD\|366944	pfam02156, Glyco_hydro_26, Glycosyl hydrolase family 26.	2.19873e-05
NC_013595.1\|WP_012894071.1\|8466733_8467783_-\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.82813e-96
NC_013595.1\|WP_012894079.1\|8477805_8479107_-\|L-lysine-6-transaminase	gnl\|CDD\|236224	PRK08297, PRK08297, L-lysine aminotransferase; Provisional.	0
NC_013595.1\|WP_012894073.1\|8469350_8469995_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|378988	pfam12900, Pyridox_ox_2, Pyridoxamine 5'-phosphate oxidase. Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein that catalyzes the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This entry contains several pyridoxamine 5'-phosphate oxidases, and related proteins.	2.11193e-49
NC_013595.1\|WP_148269316.1\|8458578_8459205_-\|RICIN-domain-containing-protein	gnl\|CDD\|379501	pfam14200, RicinB_lectin_2, Ricin-type beta-trefoil lectin domain-like.	7.15899e-07
NC_013595.1\|WP_012894065.1\|8456127_8457288_+\|DegT/DnrJ/EryC1/StrS-aminotransferase-family-protein	gnl\|CDD\|223476	COG0399, WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane].	6.25361e-22
NC_013595.1\|WP_012894076.1\|8473877_8475284_+\|hypothetical-protein	gnl\|CDD\|270875	cd13973, PK_MviN-like, Pseudokinase domain of the peptidoglycan biosynthetic protein MviN. The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This family is composed of the mycobacterial protein MviN and similar proteins. MviN is an integral membrane protein that is essential for growth and is required for cell wall integrity and peptidogylcan (PG) biosynthesis. It comprises of 14 predicted transmembrane (TM) helices at the N-terminus, followed by an intracellular pseudokinase domain linked through a single TM helix to a carbohydrate binding extracellular domain. Phosphorylation of the MviN pseudokinase domain by the PG-sensitive serine/threonine protein kinase PknB recruits a forkhead associated (FHA) domain protein FhaA, which modulates local PG synthesis at cell poles and the septum. The MviN pseudokinase forms a canonical receptor kinase dimer.	1.95718e-09
NC_013595.1\|WP_012894075.1\|8472138_8473857_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.79679e-89
NC_013595.1\|WP_052317118.1\|8465028_8465427_+\|hypothetical-protein	gnl\|CDD\|377913	pfam07760, DUF1616, Protein of unknown function (DUF1616). This is a family of sequences from hypothetical archaeal proteins. The region in question is approximately 330 amino acid residues long.	0.00612569
NC_013595.1\|WP_148269798.1\|8479950_8481123_+\|amidohydrolase	gnl\|CDD\|349882	cd03886, M20_Acy1, M20 Peptidase Aminoacylase 1 family. Peptidase M20 family, Aminoacylase 1 (ACY1; hippuricase; acylase I; amido acid deacylase; IAA-amino acid hydrolase; dehydropeptidase II; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14) subfamily. ACY1 is the most abundant of the aminoacylases, a class of zinc binding homodimeric enzymes involved in the hydrolysis of N-acetylated proteins. It is encoded by the aminoacylase 1 gene (Acy1) on chromosome 3p21 that comprises 15 exons. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity; substrates include indoleacetic acid (IAA) N-conjugates of amino acids, N-acetyl-L-amino acids and aminobenzoylglutamate. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine). ACY1 appears to physically interact with Sphingosine kinase type 1 (SphK1) and may influence its physiological functions; SphK1 and its product sphingosine-1-phosphate have been shown to promote cell growth and inhibit apoptosis of tumor cells. Strong expression of the human gene and its mouse ortholog Acy1 in brain, liver, and kidney, suggest a role of the enzyme in amino acid metabolism of these organs. Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D), resulting in a metabolic disorder manifesting encephalopathy and psychomotor delay.	9.1183e-154
NC_013595.1\|WP_031167083.1\|8477534_8477789_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.9363e-21
NC_013595.1\|WP_012894083.1\|8481672_8482347_-\|hemolysin-III-family-protein	gnl\|CDD\|224191	COG1272, COG1272, Predicted membrane protein, hemolysin III homolog [General function prediction only].	2.4696e-49
NC_013595.1\|WP_012894070.1\|8465634_8466591_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235737	PRK06197, PRK06197, short chain dehydrogenase; Provisional.	2.20369e-102
NC_013595.1\|WP_012894078.1\|8476624_8477227_+\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	2.4545e-112
NC_013595.1\|WP_012894069.1\|8461633_8465032_+\|glycosyltransferase	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	1.07573e-17
NC_013595.1\|WP_148269317.1\|8460174_8460954_-\|hypothetical-protein	gnl\|CDD\|239492	cd03398, PAP2_haloperoxidase, PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.	3.60288e-05
NC_013595.1\|WP_043653718.1\|8475342_8476602_+\|DUF2510-domain-containing-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	4.86157e-08
NC_013595.1\|WP_012894080.1\|8479251_8479809_-\|HdeD-family-acid-resistance-protein	gnl\|CDD\|225786	COG3247, HdeD, Uncharacterized conserved protein [Function unknown].	2.28588e-23

>NC_013595.1|WP_012894073.1|8469350_8469995_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MLSPTPRTTLGRSKERGRTDREDLYAVLDAGLICHLGVMAGGSPMVVPTGYGRIGDTLYLHGSTGSTSLRGTGEVCVTVTHVDGVVLARSVFHHSVNYRSAMIYGRPRLVEDDEERLAGLRAITEQLAPGQWSAARPPNRKELAATAVLALSLAEASVKVRQGPPVDEEEDYALPVWAGVLPLRSSWGAPEADPASIVDLDVPPHIATRTIPIR
>NC_013595.1|WP_012894072.1|8467792_8469283_-|PLP-dependent-aminotransferase-family-protein
MPRTCVDLPVSVDREAPVALTVQLGDRLRTAMRDGTLKSGERLPSTRALARQLSISRTVVTEAYQQLYAEGWLDGRHGSGTYVADLVIHTPATARSGSAVPGSRGALAGGGHGYGDGSAPAGGPAVPLPAGGRGHGEQMIDLRPGRPWVRDYDRAAWRRAWRKAADLPPGDRPDPHGVPRLREALAEHLRRTRTIAVGPEDIMVTRSTGNGLDLVAATLLRPGDRAGVEDPGYRVARNVFAARGAEIVPCPVDEDGVVVDGLPDDLRVLYTTPAHQYPLGGRMPISRRERLLAWARRTGAIIVEDDYDAEFRYDVAPLPALHGLDPDRVVLLGTLSKSLAPDIGVGWLVAAPELLAAIVRTRQNLSDRTSGPAQQAVAVMMEQGDLDRHLRRMRLEYARRRAAVVDVLGPMVTGDTAGLHVMVELPGEIIPSILEEARERGVLLDSTSTRHHHGEVRRHGLVIGYGSASLAEIRRGAAVVAELIGPRLADESRVAF
>NC_013595.1|WP_012894071.1|8466733_8467783_-|phosphotransferase-family-protein
MSTPGINWSRLVAWMAANVDEVGEPTGVSLISGGRSNLTYRIETQARPLVLRRPPLGHVLPTAHDMRREWRVISALAGTEVPVPEPVALCADEDVIGAPFYLMGYVEGAAVRSRDETELSPAQARALSERLAEVLAAVHAVDYGAVGLGDFGRPDGYMARQLERWGQQWTRSKTRELPEYDRLAARLLRRLPDRSPAALLHGDYRLDNTLVRLAQGADPEIRAVVDWEMSTLGDPIADLGLTLTYWQDPGDAERSSIPLAGDITLTPGFLDTGEFAAHYARVSGADLTDLDFYVAFGNFKLAVIVEGIHARFMQGKTVGEGFEHVGASVPTLIARAHRALDGHGQALSG
>NC_013595.1|WP_012894070.1|8465634_8466591_+|SDR-family-NAD(P)-dependent-oxidoreductase
MRNPPPWTLHAIPDQTGRLAVVTGANSGIGYVTARELARRGAHTVLACRDPERGRAALARLRNEVPHARLELRRVDLADLASIREFAAGWDHDRLDLLINNAGVAMVPFGLTADGFESQFGINHLGTFALTGLLLPHLLAAPEPRVVTISSEGQRFARFDLDNLNAERTYRTAFAYVRSKRANLYFATELQRRADAAGLRLRSMAVAPGLTRTNVLTGGANSGRGRLYATAVRLLVRTAFRPTPEGAKTSLYAATVPDLPGGSYIVPDGPLQLRGEPTRRTRERAIRDAVTADRLWEVSERLTGVTYGLPATAAAGLP
>NC_013595.1|WP_052317118.1|8465028_8465427_+|hypothetical-protein
MSASRLPLLLLAASGWLALLVTQVAGAGPLRVTVSVAFLLTCPGAALLALARPLLGRRDHTGDAMESMALTVALSVSAGVIVSEAFFLSGTFTMPATVTALAAVTSAAALGALVTALLTARRARRASAGRAP
>NC_013595.1|WP_012894069.1|8461633_8465032_+|glycosyltransferase
MEGREAEEVIDGSITRPMRRPASTPAPPPGGDRPGPRVPEDPGEPQDTGDPAPAPSTPEGPAGAADPEKTGDFGETSAAEAPEEADDSPTLTMRRVRPGELGRREADATGHSDEKTVAGTTQKTAKEAAEGSDSAKKPDTAEETADSQTTDDTATAPPPTEDTDTTDNTGTTQKTADSQTTDDTATAPPPTEDISAVITWRIPARREEPPAGKAADPSLSVVIVGGSPGSRARLPILVRALRAQRPAPEEIVLVVEDGPELVAWAEAALDGVVVVHNQEVAGAAAARNLGLASARGDVVAFLDDDSSPGPGWTESLLAAYADDDVIGVRGRVAVRWSTGKPDWFPAELAWVLGVPCTGSPAEAGQIDDLYGGALSFRREALAEAGGFPENADGFPERPGRRPNIVAGPAGGAATELRSRLRKLRPGAKLLHQPSAIVRLDVPAHRARLSYFLSRCAAEGRSQAGVPQRAGGREGLRAHLAPVRRGLPRAVFRAVTFTGPADVKGWKALLVMLLGLAAAGAGYAAERLRATRTDRTARRASAWTRFFARAALPVAAVLWGLSLRQVHLDRMTDLGLLTVLPATFWGAVAVLVAGFVALLGDRRALELWHAGYVLALIAVLHATPALLYPSLRYSWAWKHVSVIDYLIRHGATDPEVGPLSAYHQWPGFFSFFSLMTEMAGLDDALGIAVWGPAAFNAAILLPLLLLFRTVTRDRQLVWGAVWVYFSCSWVGQDYFSPQATTLVLYLTVLAVVVRRFRRGPVRAGDDPRGLAAEPPPVSGTFTRLVWTCLLIVPVVAIASSHQLTPLVLTVGLVALFPLRRHRNLGILLVTGLAVATWDAVAAWRLLESRFGDIVDSLGDAGGNLDDGFITLGSAAPGQVIVAYADRALSGGVWLLAFAGAIVRRGWLRRSGLPLLMIGLSPLLFLAAGSYGGEIIFRVYLFTLPLTAFLAAAFFLPSRRAWVRALVLLPVLLLMVTGFFFGNYGKEQSNYFTADEVRLVREVHRVAPPGSLIVAPTFFLPAAYDYYERYEHTWLDELPPSRTAVRGLPQHVPTLPELVRDPLPSLVGLMSKVPPGAKAYLVLNRAQRSATETAGIFPRGTVDRLGREVAASGRFRVLARNSGGVVYELVPRRP
>NC_013595.1|WP_148269317.1|8460174_8460954_-|hypothetical-protein
MAGIPRIHPWGALQHVLHRNDGLLKAFRSVEREGIPGRPARAMAMMNIAMRDVNWPAAPRTCPRITQRNPNDSVEATMDAAAHGVLKSLFPNFDFMPALNAATGQIPSWGDPAHVSGGKAEGAEIATPVVAERSGDGPAFSPAHTPDGVPGHWRPTGPANALDPNLGWLKPFAMTSGMQFRPPLPGGFTSYDQLLRSPEYAAQVNEVKALGSGRAQPGLSWRALPVGRRRAGVRPRSRRVRLHCLPGPVNGQAGAAYRR
>NC_013595.1|WP_148269316.1|8458578_8459205_-|RICIN-domain-containing-protein
MLVGGVAAVLVMIGVTVAALEGALATGPPAARTPGPVTAGPITAGSVLADGRYRMVPSHVADRDLCVGEGRERNRRTNRELAVQRPCRGLSPDTYLTAVGRDVYQIEWHHPAHGVGCLTVDQAAAGAEVLIAPANCTGAAHQRFLLERAGPRASGGFVLRPVHSSLCVGALHGVADVDVGAELAQHTCTGQADQVFLFISAPEPETGG
>NC_013595.1|WP_052317117.1|8457506_8458556_+|hypothetical-protein
MSRWILIGLAGALVATTGIYACTSSGRQTPGSGAPVVPGARSTPGSCAPTSKLVPPCGAWWGMHVPPDGDRRLVPDVTAMEQKIGRRLDITISYHDMSNSDAGRFLRDDESDLGADRILFLGWESRIWDEDVDIAWRDIAAGHYDRAIADQAARVRKYGRPVLVGFDGEKDRDESGQTPAEYVAAYKRIVDGFRQEGATNALWVWGVTGYYPFRDRWKAYYPGDAYVDWISYDPYNFAICRGATWQDFKETVQPTYEWFQQNGFAAKPLILAEYGTESHQNDTSARAEWYRDIPEAMKAMPNLKAIVQWNNTDADDCDFSLTGPGVLDSFAEAGRDPYFRQPMTPQPAG
>NC_013595.1|WP_012894065.1|8456127_8457288_+|DegT/DnrJ/EryC1/StrS-aminotransferase-family-protein
MSTALESIMRDRVGAECLHVPSARFGLYLALRHWFEAGDRVLIAPTNCETVLFVALAAGLRPVMAPVSALDGNIDPSRVDWNGLAGVLTTHLYGQPDQVGGLRAECDRRGLTLIDDAAHAMLTTVDGRPAGTFGTAGVFSLAKHGRAMSGGFLAVEDPGELPELARLRDGLLLDGGLRGQVLGTLRPMLRETVYRTGLVRPVWRALRALGVIEWTGHRQAPREEELRAALEPAAGLTALDYWMRIDLDDWRMRQGPLLRGYLRSRFRVIDRERERRLAGVELLRGLPWAARGVREAPPQPLLRVPLVVEDRDGVVARLERYGVVPGFIYDPPLDDYLDLLAPGPTPEIARWWTGHVLPVDPLRAERVATLLTRLNVHAAAEPGRNA
>NC_013595.1|WP_012894075.1|8472138_8473857_+|serine/threonine-protein-kinase
MYGTPSAWRVPGYTEIRELGAGAAGRVVMARHDADDILVAIKYLSDELRSDVGFVARFRHEARVLNTLDSPHAVRLYDYVETGEGAAIVMELVDGVALRAILRSEGPTGPEAALLVLKGALLGLATAHTAGIVHRDFKPENVMVEADGTSRLVDFGIAVRSGDGDTPAGTPPYMAPEQWTGSPAGPSTDVYAATIVFFECLTGTRPFRATNIAALARQHQAMPPPVEEVPPALQGLVERGMAKHPADRPPTATAFLTELEAVAADAYGPDWQERGRRRLAGLIGIMASLLPLEMQKPETSTSLAETEIGGRAARSTINKTSLLGKTGVKVLIGIGCIAVISGVSAVLVNSGDSTPIRAGSVTTQTPTASSDPVESVIPADETDEPTGEPSQEPSAEPTAEPTQTASPTAGPPTAAPTREPTATPKPSPSRSRKPTRAPTRKPTASSSPTPSTEESSTLDSADDPPSKSPSPKPTPTQTAAPTQTTRPTQTTRPTNTTSPSETPTTTNGPEPTGSGGGQTPTDGGSPSLTSSPTPPIETVPSALLAFGLVTSGAVPFTLAVKRGVAGRHRRRR
>NC_013595.1|WP_012894076.1|8473877_8475284_+|hypothetical-protein
MNTDRGGLAGFRLTHRTWTDELGTWSSAVAADGRPAGALSFDPRLIADPATRERLAGAVIADRGLAQAGVTGLVPIADLIAAQGEVWLLTAEPVNPTVADLLSETPGVPRPDAGSAAGVLVEIAQTLLAVHAAGLAHGALHPGTVVIAADGSARLVERGLADAIHGRPPAPERDVAAWSSLSRGLAASWAASSPGAAGLFERAAATASTHGLAPARDVLITGRDLLPPGFDTRDRLLETLHLWAAHDVRARDGRQASAPPPAPALPAPDEGDIVTLLHVPRSGESRTEDVVMRFGPGVPVETTAAQLWRAGRDQQQTEPPSDRLRVLGAPARRRRRRAAVSSAILALMVVAALVAWLLRSSAVPLAVTGLDVVAPKKTQGCGATVKIKGLLTTNGSAGEIRYQWKRSDRKDTIEQTDTVASGKTSHEVILQWSVKGEGSFKGTATLRLLSPLPEGKKLQDKATFNFKC
>NC_013595.1|WP_043653718.1|8475342_8476602_+|DUF2510-domain-containing-protein
MTTQTPSGWYPDPYGSPQLRWWDGNQWTDATHPADAPAGQGTHQTPQTGPSPQQAGPPSGGTGPWNQPSGQTGPSSQPSGSTGPWNQPSGPPSGGTGPWNQPSGQTGPSSQPSGSTGPWNQPSVQHQGPGAAQVEQPQWGSVPPHGTTMQMPAGGYGLPAGAPPRRSSPWPWILGGGAVVIAIIGVVVAAMFLFDPRGRLVAGDPTPAPEATTQEPTSQPTPDPPASPSPEQPDRATGLPQPEGGRLKDPVTGLSYEFPGAPWRVPESVGGGPLEFMWTSAALATSQENYDGQGNNWSGNVFVGELPDKFGYDGIPSMRATAATLLHATEESFYSPTHGRKIVQDKAIKVDGKDAWLLMFDLDFSKESKANGWKWKKERGAFVIVDRGAGARPGLVYVSVPDNLDVSVVDRVLDSLKLS
>NC_013595.1|WP_012894078.1|8476624_8477227_+|oligoribonuclease
MSDLLVWIDCEMTGLDLGRDALVEVACVVTDGELNQLDEGVDVVIKPPPEALEQMSEVVREMHTASGLLEVLGGGVTLAEAEALVLEYIKGHIPEPKKAPLCGNSISTDRSFIARDMPAVDMFLHYRMIDVSSVKELARRWYPRVYFASPEKQGGHRALADITESIRELRYYRAAVFVAQPGPDSATARKLAEGVSTRAT
>NC_013595.1|WP_031167083.1|8477534_8477789_+|response-regulator-transcription-factor
MRVDDAPFDAQPRVETGLSRRETEVMELIATGRSNGQIAQHLFLSEKTVKNHVNRIYAKLGVDSRVTAIGLWLERATREDPPRL
>NC_013595.1|WP_012894079.1|8477805_8479107_-|L-lysine-6-transaminase
MDVHGRLARHLLVDGYRLELDLERSRGSRLVDARTGRSYLDFYTFFASAPLGVNPFDDDPDFLALLGRIAANKPANSDLYTSHLADFIETFNRVLGDPELPHLFFVEGGALAVENALKCAFDWKSRHNEINGRSPELGTKVLHLTRAFHGRSGYTLSLTNTDPVKTDRYPTFGWPRIEVPAIHLGDVEAAEERALAQARAAFERHPHDIACFIAEPIQGEGGDNHMRAEFLQAMEALCHEHDALLVMDEVQTGAGITGTPWAHQQLGLRPDLVAFAKKVQVGGVMAGRRVDLVPDNVFQVSGRINSTWGGGLVDMVRSRRMLEIVERDGLIPRAGELGHGLLTMLLKIQAQFPEAVENVRGRGLMCAFDLPDPAERDRMVSGLRCDEGVLVLPCGERSVRLRPALSVTPEELEEGAAAIGRALAASRDLRLSA
>NC_013595.1|WP_012894080.1|8479251_8479809_-|HdeD-family-acid-resistance-protein
MEELSRTWWVYLIRGLCAILFGLLAIVWPGITIYALVIVFGAYAVVNGVFALFSTGRGGSRLWMIVYGVISILAGILAFVWPNITALALLFLIAGWAVVTGIAEIVAAIRLRKAMEGEWMFIVSGVLSVLFGILLFVWPSSGALAVVWLIGTMAIVYGIALLGLAFKVKALGAHRPGPGTSPRVA
>NC_013595.1|WP_148269798.1|8479950_8481123_+|amidohydrolase
MRDELTRLRHALHRQPELGLDLPRTQEKVLAALAGLPLEIRLGERLSSVTAVLRGAQPGPTVLLRGDMDALPVSEHSGAEVTSQVEGRMHACGHDLHTTMLAGAAHLLAARRDQLVGNVIFMFQPGEEGQGGAKIMIDEGVLDAAGERPVAAYALHVISAVLPRGVFITKGGPMMAAADKLVVTVRGAGGHGSAPHRAKDPIPVACEMVTALQTMVTRGFDVFDPVVVTVGSFHAGTADNVIPEEARFEATIRSFSKSSHTRIQERAVTLVKGIAAAYGLDVEADYQVNYPVTVNNGTEAEFVGATVREVYGEQRFIKAPQPFTGSEDFSFVSDQVPSAFVALGACPPDADPGKAAYNHAPGARFDDAVLPDGAALYAELAVRRLGLAPN
>NC_013595.1|WP_012894082.1|8481281_8481662_-|PPOX-class-F420-dependent-oxidoreductase
MTTIEDLSAEQYVCLTTFRKNGTAVPTPVWAAADGDALVVWTQAESGKVKRIRGNPGVVVAACDMRGNTRGEQVEGRARELSAGETERVRRLIVKKYGLTARALILGSRLRRGRDGTVAIRIAPAG
>NC_013595.1|WP_012894083.1|8481672_8482347_-|hemolysin-III-family-protein
MTTTAAERFTLPESIKPRLRGWLHAGALPVALIAGFVLVALGPTLQARLAAAIYAITSGLLFGISATYHRGTLSPRLEEVLRRLDHANIYLIIAGTYTPFAMLALDGPARAVVLGVIWTGAVAGVLFRVLWTGAPRWLSTALYIGLGWTAVFVLPQLLEGAGAAAVALVFVGGLLYTAGGVVYGLRRPDPSPRWFGFHEVFHAFTVAAYLVQYVAVSLVVYAAA

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Crispr_ID: NC_013595_49

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_49

8698825-8698908

Orphan

Consensus_repeat	Method
CCACGTGCCGGCGGGACCGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_49

>merge|NC_013595|49|8698825-8698908|CRISPRCasFinder
CCACGTGCCGGCGGGACCGGCACGTGCCGGCCGATCAGCCGGAGGCCGGCGGATCAGCCGATCACGTGCCGGCGGGACCGGCAC

>NC_013595|49|46|8698825-8698908|CRISPRCasFinder
CCACGTGCCGGCGGGACCGGCAC	GTGCCGGCCGATCAGCCGGAGGCCGGCGGATCAGCCGA
TCACGTGCCGGCGGGACCGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012894275.1\|8696318_8696705_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NC_013595.1\|WP_143121202.1\|8708430_8708811_+\|PRC-barrel-domain-containing-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894284.1\|8709045_8709642_-\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|379721
NC_013595.1\|WP_043653769.1\|8704862_8705108_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894279.1\|8698919_8701835_-\|ricin-B-lectin	unknown	unknown	gnl\|CDD\|227785
NC_013595.1\|WP_012894278.1\|8698274_8698652_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_013595.1\|WP_165781155.1\|8710276_8710417_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894280.1\|8702316_8702682_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_148269334.1\|8694980_8696027_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894277.1\|8697675_8698062_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894270.1\|8688875_8690186_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NC_013595.1\|WP_148269333.1\|8688564_8688894_+\|Tn3-family-transposase	unknown	unknown	gnl\|CDD\|376561
NC_013595.1\|WP_012894273.1\|8691452_8694818_+\|AfsR/SARP-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|276938
NC_013595.1\|WP_012894271.1\|8690249_8690678_-\|DUF4267-domain-containing-protein	unknown	unknown	gnl\|CDD\|372907
NC_013595.1\|WP_043657766.1\|8710736_8711441_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|225040
NC_013595.1\|WP_043653772.1\|8705966_8708279_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|223256
NC_013595.1\|WP_012894276.1\|8696719_8697676_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894272.1\|8690712_8691351_-\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|213983
NC_013595.1\|WP_043653775.1\|8709804_8710245_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894281.1\|8702828_8704733_+\|NAD-binding-protein	unknown	unknown	gnl\|CDD\|368811

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012894275.1\|8696318_8696705_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	7.8992e-06
NC_013595.1\|WP_012894284.1\|8709045_8709642_-\|nucleotidyltransferase-family-protein	gnl\|CDD\|379721	pfam14907, NTP_transf_5, Uncharacterized nucleotidyltransferase. This family is likely to be an uncharacterized group of nucleotidyltransferases.	1.07974e-05
NC_013595.1\|WP_012894272.1\|8690712_8691351_-\|hemerythrin-domain-containing-protein	gnl\|CDD\|213983	cd12108, Hr-like, Hemerythrin-like domain. Hemerythrin (Hr) like domains have the same four alpha helix bundle and a similar, but slightly different active site structure than hemerythrin. They are non-heme diiron binding proteins mainly found in bacteria and eukaryotes. Like Hr, they may be involved in oxygen transport or like human FBXL5 (F-box and leucine-rich repeat protein 5), a member of this group, play a role in cellular iron homeostasis.	5.03252e-22
NC_013595.1\|WP_012894279.1\|8698919_8701835_-\|ricin-B-lectin	gnl\|CDD\|227785	COG5498, ACF2, Predicted glycosyl hydrolase [Cell envelope biogenesis, outer membrane].	7.87811e-77
NC_013595.1\|WP_012894278.1\|8698274_8698652_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.03763e-22
NC_013595.1\|WP_012894270.1\|8688875_8690186_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	6.88497e-27
NC_013595.1\|WP_148269333.1\|8688564_8688894_+\|Tn3-family-transposase	gnl\|CDD\|376561	pfam01526, DDE_Tnp_Tn3, Tn3 transposase DDE domain. This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli. The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases.	9.98673e-09
NC_013595.1\|WP_012894273.1\|8691452_8694818_+\|AfsR/SARP-family-transcriptional-regulator	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	1.39861e-32
NC_013595.1\|WP_012894271.1\|8690249_8690678_-\|DUF4267-domain-containing-protein	gnl\|CDD\|372907	pfam14087, DUF4267, Domain of unknown function (DUF4267). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 126 and 142 amino acids in length.	9.93004e-21
NC_013595.1\|WP_043657766.1\|8710736_8711441_-\|metallophosphoesterase	gnl\|CDD\|225040	COG2129, COG2129, Predicted phosphoesterases, related to the Icc protein [General function prediction only].	1.38435e-15
NC_013595.1\|WP_043653772.1\|8705966_8708279_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|223256	COG0178, UvrA, Excinuclease ATPase subunit [DNA replication, recombination, and repair].	0
NC_013595.1\|WP_012894281.1\|8702828_8704733_+\|NAD-binding-protein	gnl\|CDD\|368811	pfam06241, Castor_Poll_mid, Castor and Pollux, part of voltage-gated ion channel. This family represents a short region in the middle of largely plant proteins that belong to the TCDB:1.A.1.23.2 family of the voltage-gated ion channel superfamily, eg UniProtKB:Q5H8A6, Q5H8A5 and Q4VY51.	1.76665e-21

>NC_013595.1|WP_012894278.1|8698274_8698652_-|STAS-domain-containing-protein
MSRELVIRVTHHEETGCAVLTVRGDIDRNSSPLLREAIGELVSDRRVRIVLDVEGVTFCDSNGLRTFLSGMTSTFEAGGWLRLAGVRGHFERLLRMTDLYNFFSIDADVPGSLEHASRGGFRPSG
>NC_013595.1|WP_012894277.1|8697675_8698062_-|hypothetical-protein
MAESAPAQGQSEPMSYDHDQLEKRVAPGFGMVGGDLHEAVKRAADALKALGDLPSGEETDQKFLRWFTPKRDQMLALTDDLADAYGDIGDGLLAMHRGVLVLDWGMADDLTKLPDYLADGPAAKRDGA
>NC_013595.1|WP_012894276.1|8696719_8697676_-|hypothetical-protein
MAISPMLGLKVLFGAGMGYLVALRIYGGVTAPEIPPDKLREIARIFNRLADDLDGGTGENADKGIADRADALAASVWDNGRNSGQAVDAFRGLYQGAVSGYAPLLAKDCRVVAIGCQAYAELVEDAHEGLAQLEDLILQIMWVVTFQPMTTALYGVAAARIAALIKAAKGLKSTFALNAARIMEMTVPKYAMTTLFYMAIDGAAYAAGSMAITKGVQLAHDRPLGSAGENAEEFGKIVGANGAYVLGYDLAKLPFRGMPTTRGIELGARLIGSGLGYTPAYSAMDGDGELLPTYDEWAAKFSGHGLRAVIFPPGWKFK
>NC_013595.1|WP_012894275.1|8696318_8696705_-|YbaB/EbfC-family-nucleoid-associated-protein
MGYPDEAALRRMEDGLGDIVGEGEAADGLVRAVTDAAGRLVKITFNPRVMRMDSQALAEETGAAVRRAQEDGQRRTHELVGGALGRSAPEHLPDHTEFWNGLREMREAFDRSMTDREAEVARRLRDLD
>NC_013595.1|WP_148269334.1|8694980_8696027_-|hypothetical-protein
MTFMLAAGLVTVAASAQASVPNRWGFAHVNVNSGIPDPARQAGSWGAGFNVTVAPGGVGQTYVTFPQLAIDGGVVHVTAISQTAYWCQAQKWGPVGPDLVVVVQCYKYGGGPVFTPYSIVFEQSTGTLPAPQAFGYVHYDGASIASQFNSAPAVNTVAGGGGVWTVTLPGLGSAGPAGNIQVTAVNPVQPARCKVGGWASAVGAQTVQVRCHNATNVPLNTGWTLTYQRERAITGAAVPPKNFAYTFDNTPANPGPYSPVPAAVNYNSQLGINTVQNAGLGQRLVTFPRVGVLPDDVQVTAYGPGPEYCNLQTLWNTSGSVAIVRNVVCYNGTTRVNQPSLTTYTSAF
>NC_013595.1|WP_012894273.1|8691452_8694818_+|AfsR/SARP-family-transcriptional-regulator
MVFIRVLGSFGAEVGGEPVPLGGPRQRGVLALLVAARGQVVPVDRMIEDLWRGEPPARALMSLQAYVSNLRRTLEPGRPPRTPARLLVSASPGYALRLPPESVDAWRFEGLLDQARTVTDPRVAQARLAEALGLWQGPAFAEVADEPWAGAETARLNELRLVATELHVATGLRIGDPAAVVPEAERLTRDEPLREEGWRLHALALWSSGRQADALATLRRARGIFAEELGLDPGPDLTALEEAILTQRTDVMRASVPPPPPTAPLPRPAPSIEAPFVGREAQLSALVTAAAEAAADGARIALVTGEAGLGKSTLLEHLGRRLERDGWLVAVGRCPEVDSAPPAWGWTEALRAVAATTSPGGFADDLAPLLTDTGPADYDATAGRFRLRQSVWKWLAAVATERPVAVVLDDLHWADAATLELLGGGLRMRAPILIVAAYRADESGHLTETLASLARATPLRLALPGLNDEAVAELVRTECEADEEAIAGIAERTGGNPFYVRESARLLNGEGALVALSEVPEGVRDVLRRRLARLPEGGVSILRLAAVAGRESSVDVLVKAADTDEDGVMDALDAGVIAGLLDEPGPGLIRFVHALVRDTLVTDLSRLRTARMHARIAAALEGTDDIAALAHHYARAGSPKAVGYCVQAAERAEARYAHDVAADLLTDAVANSTGPDERVELLGRLLRAQIRAGAVAAARETRREAVEYAESLGRDDLMIAAFTAWTEPTPWQARTYGTVDRPIVDRLSRLLKRDLTPSVRSRLLTAYAHELVGEDDPTVVEAAQEALDLATEPRLRAAALQILAEVHGDAELCRELVEIGTEHDLPVYRVTGLLNHAGVAAAANDPVTTHQVTTEALELARTYRMREAIAAAEITLASLALIEGRFADAELLYIKADEGMRRAGSVHTGFLQLALATIWLNEGTLGAHLDDVRALHAALGPMTSDLLALALHANGLDAEARQVRASPSPIRPDFFFTFLTTLRAMAIVALNDRDAAEEIYATLLPHRNGPPAGAASLSVALRPVAHTLGELAVFLGRDHEAAAHFTQAATIADRWNAPHWAAEARLRTTRRLLDDEGDAALAELPPSRLAQHRPDDLSGSRAVHSGRPPAPYSNPNPGLSS
>NC_013595.1|WP_012894272.1|8690712_8691351_-|hemerythrin-domain-containing-protein
MSVNTQDMEIVHRVLRRESRLLMELVAAVTPGDTARAKVIADHFHVYRLGLHNHHEGEDELLWPPLLSRVDLEADIVLRMQAQHERVAATLTRLDATVPAWEATAGADERDTLVAALSEHRAVLLEHLDDEETTLLPLAAKHITQQEWASLGDHLVNNTPKLTLLTLFGAVLEDANPAERAIVLSGLAAPVRVIWHVIGRPRYARHIRRVRG
>NC_013595.1|WP_012894271.1|8690249_8690678_-|DUF4267-domain-containing-protein
MSLKKLNTVLATAVVLFTLYLGLSFVLPLETSFPGLPNWPSGDSGFPVVKGSREIAMGLAMGILLVTGHRRALGWVLLMVAVAPFGDMVNVLAHHGSTAAAFGIHGLTSALIAVTGLLTLRETSKARKAQETATPAPAAQPA
>NC_013595.1|WP_012894270.1|8688875_8690186_-|FAD-binding-oxidoreductase
MTINDLRGVLKGRVLLADDDGFEQAATAWNLTVRQPVAAVVEAADADDVAALVRYARRAGMTVTAQPSGHGASGDVDGLILLRTGLLNEVEVRAQERVVRVGAGVKWGQVLAAAGPLGLTGLSGSAPGVSVTGYTLGGGVGWFSRKYGFASDSVRAIDIVDADGEPGRVTAESDPELFWALRGGGGDFAVVTALELELYPAPVLYGGRVIWPEHRTREVYDAFLETTAEAPRELSVWINRLQPPGAPPMVTLDLAYLGEAAQGEDLLARIDKIEGAISDSRGVVPVADLGDIAAEPTDPAPSIARAELLTGLDADAVELLLAKPVEPLINVQIRHLGGALADPGGGAGASGAVAEPYLLGLVGLGLPHVADATRAKQAEVVADLEAYISGRKPYTLLTPGDTAAKSFSGSALARLREIKRARDPHNVFRANYPVLG
>NC_013595.1|WP_148269333.1|8688564_8688894_+|Tn3-family-transposase
MAGSLKYGQATASLVVGKWSAASRKNTLAAALKEWGMLRRTLHAANRCAGGSADRHGAPETPHCASPSCVGVPFTVLAATSVTRVRCGPAAPVGGGAVTCWEPIYPSTG
>NC_013595.1|WP_012894279.1|8698919_8701835_-|ricin-B-lectin
MHPSIRTTGPDSAQPRERRLIHRPWARRRALVAGVAVAMVAGMFGLGLARSAEAATVGAGSYADTLPAGRSLPTGCGSISTNPRQWVTANAPAGAVPTNDWWSSILYKKTDCSYGEPLHAHPISYDTSGTGLSFSYTTTPAISGTATGVGEFHYPYVQDIQVGVAGLNSPDVKVDGWSDWTVTPYWSGGGRTMKATIGHGLPFGYFQITGGDARITAAGTPSVWSNSGATIGFTVNGHDYVAYAPTGATWAVSGTTISSSLAGRGFFSVAVLPAGGDRAALANTYGQYAHAHVTGTRVSYSYNPASSTLSTTYAFTTTARQGGATGTVTALYPHQWNHLTGSTPLAQTYVSARGQMKIVTGTQFTTSMKYTGVLPEVPAVGDGTGADLATVTGLLNAELGNPMDNRGDDTYWTGKGLGRAARIAEIADQLNLTSVRDAALGAIRTRLNDWFTASPGKTSRVFYLDPAWGTLIGYPASYGSDQELNDHHFHYGYYVAAAATLAKYDPNWAKTSQYGGMVDLLIRDANNYDRGDTRFPYLRDFDIYAGHDWASGHGAFGAGNNQESSSEGMNFANALIQWGQATGNTAVRDAGVYIYTTQAAAIQEYWFDVRDQNFPAAFGHSTVGMVWGDGGAYATWFSAEPEMIQGINMLPITGGHFYLGDNPAYVTTNYNELTRNNGGPPTVWRDILWEFLALGNGDAALANFRANSGLTSEEGESKAHTFHWIRNLAALGTVDTSVTANHPLAKVFSKNGARTYVAANITGAAITVTFSNGTTLNVPAGKTVTSGAHTWSGGNAGGGTGPSPQPTPTVTPTVGPFAATRYPQAGGGLPGAAGTAGTVTLAAANGNHDGTPVNAQIFTATGLTAAHNGGATAFDLFVDAGTTVANGVQARVSYDLTGDGSWDRVETYRYFATDPVAGWEHYTQAAGLQSSSGTLGNLSGGRVRVEVWNAIGGGVTTLGTGDRSVVRLPFG
>NC_013595.1|WP_012894280.1|8702316_8702682_+|hypothetical-protein
MRSKRLTTIALAALVGCASLTTVAAATPATASVPAAPTAADFTGYQVVKLPNANVPNFQRRTVRCPSGKRAIGGGAEAQGNDAILVGSFPTDDGAGWIGLGRQNNYNDVGISVYVICANVS
>NC_013595.1|WP_012894281.1|8702828_8704733_+|NAD-binding-protein
MRRLRYRFDNLISRGAWTMIGLLAVVALVMAAVGAMAILALSPHSMDLPSALWSGLMRTMSPGMVARDIGSPVFLTSMLVLALAGVVIFSTLIGLIETGLDRKLARLRKGRSRVIEHDHTVVLGWSEQVFLILSELAVANASRGRSCVAILADMDRVTMEEAIRERAALPRRMRVVCRTGNPTDPVDVAIVSPERAHAVIVLGAEDGDSDARTVKTLLALDAAGVRPEVQLVAGVRDPRNLAAARLAGGANTQVVDVGEIAARIMVQTCLHAGLSMVYSDLLSFEGEEIYFCPPGELAGRRFGDALTALENCSLIGLEQGGKAVLNPAGETQIGVGDRLVVIADDDGTAPLHTSAGVDRDAIAVTGRDGPAARRVLVLGWNACGAAIVTEFDHYIPPGSQVTVVADDPRVTSQVSSLSARLGNLTLSYATEDVTRRDTLDSLGLGSYDHVLILAGDRVDAQVADSRTLLTLLHVRDMSRDNGWRHSLVTEIARDCDRRLVEVTEVDDFIVSSKITSLLMIQIAENPHRYGLFADLFDAGGQEIYIRPAEDYVRLSVPVNYATVVAAARAYDEVAIGYRAAGAATGTVGGGIVLNPPKSTDLTFHPGDAVIVLADGALHPGRGPHPAGARRVEHA
>NC_013595.1|WP_043653769.1|8704862_8705108_-|hypothetical-protein
MSVSELAQVLFASALQASDDPSPDQVRTVIEDGLRACHEDLTSCAACVAQEAGDHPEAYATRMRWALCAAHQVDPATLATA
>NC_013595.1|WP_043653772.1|8705966_8708279_+|excinuclease-ABC-subunit-UvrA
MSMTPRTDTQSPAPHVADSHDLIRVQGARENNLKDVSIEIPKRRLTVFTGVSGSGKSSLVFGTIAAESQRMINETYSTFVQGFMPTLARPEVDLLEGLTTAIIVDQERMGANSRSTVGTATDANAMLRIVFSRLGEPSAGPSFHYSFNTPAGACPRCEGMGSVTDVDLTQLYDDSKSLAEGALTIPGYSMDGWYGRIFSGCGFFDPDKPIRKFTKAELHDLLHKEPTKIKVDGINLTYEGLIPKIQKSMLSKDRDALQPHIRAFVDRAVTFTACPECDGSRLNEAARSSRIKGVNIADACAMQISDLAEWVHGLDEVSVAPLLATLRQTLDSFVEIGLGYLSLDRPSGTLSGGEAQRTKMIRHLGSSLTDVTYVFDEPTTGLHPHDIQRMNDLLLRLRDKGNTVLVVEHKPEAIAIADHVVDLGPGAGTAGGTVCYEGSLEGLRGSGTLTGRHLDDRAAIKETVRTPKGTLEVRGATAHNLRDVDVDIPLGVLCVVTGVAGSGKSSLVHGSIPAGAGVVSIGQGAIRGSRRSNPATYTGLLDPIRKAFAKANGVKPALFSANSEGACPNCNGAGVIYTDLAMMAGVATVCEECDGKRFQASVLDHHLGGRDISEVLAMSVTEAEEFFGAGEARTPAAHAILNRLADVGLGYLSLGQPLTTLSGGERQRLKLATHMAEKGGVYVLDEPTTGLHLADVEQLLGLLDRLVDSGKSVIVIEHHQAVMAHADWIIDLGPGAGHDGGRIVFEGTPADLVAARSTLTGEHLAAYVGT
>NC_013595.1|WP_143121202.1|8708430_8708811_+|PRC-barrel-domain-containing-protein
MRTMSELWTYRADVYDVNKSLDIAGYHVEATDGKIGSVDEATYDVGESYIVVDTGPWIFGKKVLLPASTVTRIDPQERKIYVARTKDEIKHAPEFDEATFKEPTYRDTVGEYYGRFPFGAGPGGTY
>NC_013595.1|WP_012894284.1|8709045_8709642_-|nucleotidyltransferase-family-protein
MGSHSHEVTDAILETLKRASSGLKDADVRFALAGGCAAYARGAAPSLHDVDFVLPQEDVPTALEALRGLGFETAKPPEDWLVKAYDEGRLVDLIFSICDHPVTPALLERAEPMKASAVILPVLEATDLVISWLLPLSEHSCDYGSLLPQVRALREQVDWDRVAAVAQASPYAFTFLTLLERLEVIPGALDPTGDPSWP
>NC_013595.1|WP_043653775.1|8709804_8710245_+|hypothetical-protein
MDRELGELMQGLRVAVTGVQVLFAFLLTLPFAAGFHKVDALGRWLFFIALLSAALASICFITPAAQHRLLFRTGLKEKMLHRANELGVAGAVGLAIAMTSSVALVAETVINAWPAALFGGVIALASGWLWILQPIVDLYRTKDVKS
>NC_013595.1|WP_165781155.1|8710276_8710417_+|hypothetical-protein
MLWIIAVVLVVAGIYVILARRDLLWGIVLIVLGFLVGPGGVSIFNV
>NC_013595.1|WP_043657766.1|8710736_8711441_-|metallophosphoesterase
MRIAAVGDVHLDESLRGRYRERLDGIEEHADVLLLAGDLTRHGTLEEARVVADEFRDLPIPVVAVLGNHDHHSDLPAEIAFMLTEAGIAVLHDDATVLDIDGVRLGVVGGKGFGGGYAGKCASDFGEPEIKAFVGHTKRIAERWRVALKELQADRRVVLSHYSPVKDTLHGEPLEIYPFLGSYLLAEAVDAEGADLIIHGHAHAGTEKGVTPGGIRVRNVALPVLGRAYGVYCL

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Crispr_ID: NC_013595_50

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_50

8933504-8933591

Orphan

Consensus_repeat	Method
CGGTCCCGGTCACGCCTCCTGGCGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_50

>merge|NC_013595|50|8933504-8933591|CRISPRCasFinder
CGGTCCCGGTCACGCCTCCTGGCGCCGCTCACGGCCCCGGGACCGGTCATGGCCCCGCTCACGGTCCCGGTCACCCCTCCTGGCGCCG

>NC_013595|50|47|8933504-8933591|CRISPRCasFinder
CGGTCCCGGTCACGCCTCCTGGCGCCG	CTCACGGCCCCGGGACCGGTCATGGCCCCGCTCA
CGGTCCCGGTCACCCCTCCTGGCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_081453504.1\|8936235_8937465_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_013595.1\|WP_012894497.1\|8938144_8939335_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NC_013595.1\|WP_012894499.1\|8940385_8941165_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|238847
NC_013595.1\|WP_012894484.1\|8922750_8923194_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NC_013595.1\|WP_169369475.1\|8944829_8947016_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012894493.1\|8933592_8934663_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_013595.1\|WP_012894496.1\|8937509_8938016_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380063
NC_013595.1\|WP_012894490.1\|8931210_8931507_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894487.1\|8929040_8929445_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NC_013595.1\|WP_012894498.1\|8939413_8940367_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NC_013595.1\|WP_012894501.1\|8942868_8944833_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012894494.1\|8934722_8935769_+\|DUF695-domain-containing-protein	unknown	unknown	gnl\|CDD\|368292
NC_013595.1\|WP_081453503.1\|8920497_8921445_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223039
NC_013595.1\|WP_012894488.1\|8929795_8930977_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_013595.1\|WP_012894483.1\|8921799_8922681_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043653845.1\|8924922_8928921_+\|type-VII-secretion-protein-EccC	unknown	unknown	gnl\|CDD\|274858
NC_013595.1\|WP_012894491.1\|8931503_8932754_+\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|381605
NC_013595.1\|WP_043657857.1\|8923339_8924734_-\|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl\|CDD\|274855
NC_013595.1\|WP_012894492.1\|8932846_8933488_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|316044
NC_013595.1\|WP_012894500.1\|8941492_8942809_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012894497.1\|8938144_8939335_+\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.99692e-67
NC_013595.1\|WP_012894499.1\|8940385_8941165_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	9.77055e-91
NC_013595.1\|WP_012894484.1\|8922750_8923194_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	0.000353483
NC_013595.1\|WP_169369475.1\|8944829_8947016_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.22658e-86
NC_013595.1\|WP_012894494.1\|8934722_8935769_+\|DUF695-domain-containing-protein	gnl\|CDD\|368292	pfam05117, DUF695, Family of unknown function (DUF695). Family of uncharacterized bacterial proteins.	2.86296e-06
NC_013595.1\|WP_012894496.1\|8937509_8938016_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|380063	pfam17937, TetR_C_28, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in CgmR (C. glutamicum multidrug-responsive transcriptional repressor), previously called CGL2612 protein. CgmR (CGL2612) from Corynebacterium glutamicum is a multidrug-resistance-related transcription factor belonging to the TetR family. It regulates expression of the immediately upstream gene cgmA (cgl2611) by binding to the operator cgmO in the cgmA promoter. The cgmA gene encodes a permease belonging to the major facilitator superfamily, a protein family composed of bacterial multidrug exporters, and the pair of CgmR and CgmA confers multidrug resistance on C. glutamicum.	3.08931e-12
NC_013595.1\|WP_012894493.1\|8933592_8934663_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_013595.1\|WP_012894487.1\|8929040_8929445_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	4.26336e-10
NC_013595.1\|WP_012894501.1\|8942868_8944833_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.42911e-78
NC_013595.1\|WP_012894498.1\|8939413_8940367_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	4.44894e-108
NC_013595.1\|WP_081453503.1\|8920497_8921445_-\|hypothetical-protein	gnl\|CDD\|223039	PHA03307, PHA03307, transcriptional regulator ICP4; Provisional.	1.20576e-06
NC_013595.1\|WP_012894488.1\|8929795_8930977_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	9.26996e-26
NC_013595.1\|WP_081453504.1\|8936235_8937465_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	3.04046e-173
NC_013595.1\|WP_043653845.1\|8924922_8928921_+\|type-VII-secretion-protein-EccC	gnl\|CDD\|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NC_013595.1\|WP_012894491.1\|8931503_8932754_+\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|381605	cd13402, LT_TF-like, lytic transglycosylase-like domain of tail fiber-like proteins and similar domains. These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	1.15702e-32
NC_013595.1\|WP_043657857.1\|8923339_8924734_-\|type-VII-secretion-integral-membrane-protein-EccD	gnl\|CDD\|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	3.35481e-41
NC_013595.1\|WP_012894492.1\|8932846_8933488_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|316044	pfam13483, Lactamase_B_3, Beta-lactamase superfamily domain. This family is part of the beta-lactamase superfamily and is related to pfam00753.	1.47252e-23
NC_013595.1\|WP_012894500.1\|8941492_8942809_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.43104e-84

>NC_013595.1|WP_012894492.1|8932846_8933488_+|MBL-fold-metallo-hydrolase
MKLTKFGHACVRLEKDGSVLVIDPGSFSEESALDGAQTVLITHEHFDHVEADRLRRAAEANPSLEIWTNEGVAATLTGVPAKIQVVRHGDTFDTAGFGVRVVGEWHAPNHPDMPIVRNVGFLVEEEVFYPGDAFTPPGVEVPTLLVPTNAPWMKASEMVEYLRQVRPARAFSTHDGLLNDIGLGLVDSWLGLESDRQKAEMRRLKPGESVTLP
>NC_013595.1|WP_012894491.1|8931503_8932754_+|transglycosylase-SLT-domain-containing-protein
MSDDRGSLTDRDGDREPIVPVVPGSSELLTIAMKVNGAKDSITTIANRWRTTAGDLNDHAIELTRAVNTVDHSWQGDSADAFDDYMRKYGKAGDALHLALADCAGALDTAAGALDTAETKVKTLTENLVTEWNTYRTNNSKNADGSTRTETELAAGIKPSVDTAVSNARLQLDSADKAVTQAAADLKTYMDERSIHFSDIPAVGDERFMAPDRVLHWEKTPLANPGQTTLAGTNGGNGGNGGNGSGGSGSGGDASGVIGSGGTSSGGTIPQPKEKVVGWIKEALTIIKSGKIDGFLARKGILEKVKDLDPNDPKDIERIWKIIFHESGGNPNAQNNWDINARNGVPSQGLMQTIPPTFAAWSPEGHKVIKDPVDNIIAGVLYTYGRYGSLAEHPGIASLERVDAQGRPDPGGYKPY
>NC_013595.1|WP_012894490.1|8931210_8931507_+|hypothetical-protein
MKNVDVHFDALDDCRTAAKKLMGKFGALAETYPAQSTDSSIFGRLTSSSALAAAVDGIEKTVDSEMGNVQSKLDGVEHALSTVAENLRNVKYPRVDSS
>NC_013595.1|WP_012894488.1|8929795_8930977_+|C40-family-peptidase
MSDDRGSLTDRDGDREPITPVVPGSSELLTIAMKVNGAKDSITTIAKRWRTTAGNLNDHAIELTRAVNTVDHSWQGDSADAFDDYMRKYRKAGDALHVALTDCAGALDTAAGALDTAETKVKTLTENLVTEWNTYRTNNSKNADGSTRTEAELAAGIKPSVDTAVSNARLQLDNADKAVTKATTDLKKYMDERSIHFSDIPAVGDQKFMAPDRVLHWEKTPLANPGQTTLAGTNGGNGGNGGNGASLSGSGGSGGNGPAGGDPGGPAQALPYVPGSGSGAAIVAAAQKHIGKPYVWGADGPSAFDCSGLVYYTLNQAGIKIGDTTAAGYQASGQPITPPPQPGDIVFFGDPATHVGIYAGEGKMIHAPRPGTMVRVEDVAGAAAGPITYRRFT
>NC_013595.1|WP_012894487.1|8929040_8929445_-|YbaB/EbfC-family-nucleoid-associated-protein
MNDEFRITMEGLADEYNKQAAQLRETYGKLNDLTATAQSDDRMVTVTVGPRGQVQGIELDPRVYRKLSPSELTHSIMEQIGVATGEVSARMQELMTPLVPDGLPYEELFGEGASFESFLPQPVNLPSREPEDRR
>NC_013595.1|WP_043653845.1|8924922_8928921_+|type-VII-secretion-protein-EccC
MSIVIVRRPERRPPPKPPRGEILLESPPEVPEVQPQGFMAVLTYLPMIAGGAAMGLMFTAGGNSNPLMYVASGLFAISMVGMSLGQMGRQSGERKNRLNNLRRDYFRYLSQVRKRVRQAAKQQRAALEWGGPAPESLWWVAMSQRLWERRPRDDDFGTVRLGTGVQKLAIQLIPPDSKPIEDLDALTSGALRRFVRAHSTVAKLPVAVALHSFARINLTGDPVAVRELVRAMIAQLTVFHSPDDMRVMVCASKEWMAQWDWVKWLPHALHPEETDAAGQVRLMAENLSQLDHLLGSELKERARFKPGASSDALPYHVLIIDGGHVPHDSQLGTDAIQGVTVIDLSGAAGPIEEKNTLRLDIQPDGFHMIKIDHAGKESSTRLGDPDRLDFLRTEGLARQLAPLRVSTAKGGETQDVLAMNTSLTDLLGVGDPTRLDASLTWRPRAGRNRLRVPIGLGVDGRLVELDIKESAQGGMGPHGLVIGATGSGKSELLRTLVLGLAITHSSEILNFVLVDFKGGATFLGLDTLSHVSAVITNLEDELPLVDRMYDALHGEMVRRQELLRAAGNYASLRDYERAREQGVDLKPMPTLFVVIDEFSELLSAKPEFIELFVMIGRLGRSLGVHLLLASQRLEEGRLRGLDTHLSYRVGLRTFSAMESRVVLGVADAYELPSAPGNGYLKFETTGMTRFKAAYVSGTYQADHSQGVTPDGQAILRQVVEYGPDFAPVPVVEEPKKELPAADGPADRGSVTLLDLVVSRLHDQGPPAHRIWLPPLGDPPSLTQLLPPLSATPELGLGTIGWVGRGQLHAVVGLVDKPFEQRSDPFWLDLSGAAGHVGVAGGTQSGKSTVLRTLIASMALMHTPREVQFYCLDFGGGALASLEGLPHLGGIASRLDGDRVRRTVAEIATLLQQREREFTDQGIDSITTYRRMRAEGTIEGDRFGDVFLVVDGWLTVRQEFETLEPVITDLAARGLGYGIHVVAATNKWSEFRPGIRDLFGTRVELKLGDAYESEVNRKASLAVPEGVPGRGLTREGLHFLSALPRIDGVQKADDLSDGVRALVHAVRDAWQGPPAPAVRLLPAVLAAETLPDAEQSGPNRIPLGIDEATLSPVMLDFDADPHFIVVGDTESGKSNMLRLITEGLVARHTPQQAMMIVIDYRRALLDSAATEHRIGYAASSAAALELIADVRNALLKRLPPADLTPEQLRSRSWWQGSDLYIVVDDYDLVATSSNPLQPLADLLPQARDIGLHLVMSRAMGGVGRAMFDPIIQKIKDMASPAVVLSGNKDEGFVFGNVRPHPLPPGRGYFVDRRHGARLVQTAFVAPPSPPEES
>NC_013595.1|WP_043657857.1|8923339_8924734_-|type-VII-secretion-integral-membrane-protein-EccD
MAQFAAPLPTLCHVTIVAPRRKADLALPADIPLPHVLPGLLRAVGEIGGDASAGPGWVLQRLGGAPLDLGQSLGTLGVLDGEVLYLRPQEAMLPPALFDDVADVVATGVQEGSDKWGPRHTRLAGVGAAVALLLTGVAALVLAGPPWTPAAVVAVVFAALLVAAGAAMSRAAGDSPAGALIGYAALPYGLLAGLLAPSAAGGLGGLGAAHMLAAFASVGLVATIAVIAIADGVPVFLGAAIASMTGAVSAAVVMVSQAPAAGVAAVTVAILLGFTPLIPVLSFRLARVPTPTMPTTADELRNDNQQIDGPLVEERTAHALSYATGMVAGVALVALVAQAYLVMHGGWVATANALTLSLTLIMRTRVFHGFGQRLWLMISGVSGLVMFAISQAAGGGGPTAIIVVMGLLGAAAICAGLGMWLQVGKPSPFWGRAGDIVELLLIVALFPLALGVLEVYSWVRGLSG
>NC_013595.1|WP_012894484.1|8922750_8923194_-|YbaB/EbfC-family-nucleoid-associated-protein
MQEFGDFANIDIDKLLKGADEQFARMEEMQKGMADLVGRAQDDDGLVTVEYAAEGIRELQLHPKAMRLSAGELAEKVKDVIAAATTDLQKQVNEVMAEVFGEEDNPMSYINDPDKAMNQIKDAEAAYNRTFDDVMGELDSIRRRMNL
>NC_013595.1|WP_012894483.1|8921799_8922681_+|hypothetical-protein
MAFAYHAGTSIYTSAIGMCTAASVMPSLPPSPMFRSIAISSGLLMTLQFSSPSDIDGTKQVWKDLCKELDEAHIDLNSFTSGVDPEKWQNMGKEEFDAACKKFYDEMGKTRDCCNNIGDSLGGAALMSFAAAVICAILGGILLKMAIAKAAASAAGPVGALTATTITTAGATTIRQNLRAMVAKSGKSLMMIATIVGMGYMLLQMLTSSTQQGLSQAATPTDMKSTPMFEQVFIEGLPQSFGQTTSGDQTTTGDQTTTGDQTTTGDQTTTGDQTTTGDQTTTGDQTTTGDQTA
>NC_013595.1|WP_081453503.1|8920497_8921445_-|hypothetical-protein
MICSRCCLARSFAAASAFAFASASAFAFAAAAAFFCSSVRGAVPPPEPAPPTFGTPPPPPESAPPRFGTPPPPPEDGEGRSGAGDPPESPGVSPVPAGGVTSGVSGASGVSGTSGSLGSSGLSGSSGSFGSPGLSGSLGSSGLSGSSGSFGSPGLSGSLGSSGLSGSSGSFGSPGLSGSLGSSGLSGSSGSFGSPGLSGSLGSSGSLGSSGSLGSSGSFGSPGLSGSLGSSGSFGSSGSFGSPGLSGSLGSSGSLGSSGSFGSPGLSGSLGSSGSLGSSGLSGSSGSFGSPGLSGSWGAFGSVMISILGPSFAAA
>NC_013595.1|WP_012894493.1|8933592_8934663_-|tRNA-2-thiouridine(34)-synthase-MnmA
MRLRVLAAMSGGVDSAVAAARIAEAGHDVTGVHLALSANPQSYRTGARGCCTIEDSRDARRAADVIGIPFYIWDMAERFHRDVVEDFVSEYAAGRTPNPCLRCNEKIKFEAVLDRALALGFDAVATGHHARIADGVLSRSPDEGKDQSYVLGVLTREQLKHAIFPLGDSTKAQVREEAARRGLMVADKPDSHDICFIADGDTRGFLADRLGAEQGPIVDESGAVVGRHEGAYGFTVGQRKGLHIDRPAPDGRPRYVLSIEPVSNTVTVGPRSALEVTGIVATRPVWNGPADVPHEPLTCTVQLRAHGEVYGCRAQLSGDEVHIALDTPATGVAAGQAAVLYLGDTVIGSATIATAA
>NC_013595.1|WP_012894494.1|8934722_8935769_+|DUF695-domain-containing-protein
MRLFGRKDEFTAEPADGIGEFWTWWAEARPELDAMVAAGEADRLAEWIGPAVQVVHPSLVWEIAPGLGSDQALVVTSAGDPELRPTAHRWAAAAPAADALWEFHPSRRANPHAMELTLDVGGYEFALDKLMLGLRAPLGNPRVDVVAYHPIFTILDDDTRIEAALLALDWLLGEDDVARWVGDISAAGFEPIDAVPAVHLPSVVADLASGYRDEQWALLEGETATGARLIATARYPLRPVDHPLFDQHIAITLPYLHGDADGLPVGRSLEALRDFEERLAGRISRLNGSAVFAAHMSAEGQRVLHVYADPVGDAAIHAKELIVSWEEGRPRVDVVGDPGWSAISPFLT
>NC_013595.1|WP_081453504.1|8936235_8937465_-|cysteine-desulfurase
MAPSGTTDTLGRQKRAGEGSAAVESAYLDHAATTPMLPEAIEAMTAQLGRVGNASSLHAAGRRTRRVVEESRETIAYALGARPSEVVFTSGGTEADNLAIKGLYWARRANGASRILLSAVEHHGALDPARWLGDRQGATVELLDVDEYGRVHPQTLRAAIERDPESVALVSVMWANNEVGTVQPVRVLAGIAHDHGIPFHTDAVQAVGQLPVVFTGSGVDALTLSGHKVGGPMGVGALLLARGVDPVPVLHGGGQERDVRSGTLDAPSVAGFAAAVKTAVARQAETSARLTGLRDDLIRRVRQAVPDVILNGDPVNRLPGNAHFSFPGCEGDALLMLLDAKGVECSTGSACSAGVAQPSHVLLAMGADAVRARGSLRFSLGHTSTGADVDRLIAVIGLVVERARRAGLS
>NC_013595.1|WP_012894496.1|8937509_8938016_+|TetR-family-transcriptional-regulator
MRREELLDAAEDLLCDQGSQALTLAAVAERAGCSKGGLLYHFSSKEALIKGMVERLIEDFDQLIAAQGHDTYTKNYLAATFAAVQSGRLRRWAVVTGASGNLYLLAPLRVAMARWHREGLGSEPDPAAAQIVRLACEGLWDVATHDPDLYDDDHYAELKRRLLDLLPA
>NC_013595.1|WP_012894497.1|8938144_8939335_+|MFS-transporter
MTRDLRTARIGAVLTFVLAGLLCGTMTVRIPALSDKLGLSEGSIGVTLLVWGLGALVTMQSMRGVMTRFGSRSILRVGAPLCAATLALLAFAPTFPLLLVAAGLFGMAFGAVDIAMNAQGSAVERAYGRPLMNGMHAGWCVGAISAGLLGTAAIAAGLSFTAHLALIALLTLPLLVIVSRTYLPDPAVTTGGEARARHRMPPVVYLLGVIAFCAFMVEGTVADWNGLYLRNVLGAPEALAALGYPIFEAGMLLGRLTGDRVRARFGARGMIITSGLATAVTFTVVITASTALVALSAMFFVGIAVATVSPMAMSLAGGAVDNPGPAIAQTGAMGYAGLLLGPVIIGFLSDVATLGTALGIAVVLGVVIALVARFLPRSLRDATPAETPERELSMAA
>NC_013595.1|WP_012894498.1|8939413_8940367_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MSEILVLVEHVEGQVKKVTLELLTLARKLGTPSAVWAGPGYSPDAKARLAEYGAEKIYVADSADISDYVVAPKAELLAQLVSEKSPAAVLVAATAEAKEIAGRLAIKIDSGLLTDVVGLQDGLVADQSIFGGGVNVQSRVTKGTPIVAVRPNSTPVEAAAGAGAEEQVSVTVSAAARGAKVVDRVKEEKGARPELTEAAIVVSGGRGVGSAENFSIIEKLADSLGAAVGASRAATDAGWYPHQFQVGQTGKTVSPQLYIAAGISGAIQHRAGMQTAKTIIAINKDAEAPIFELADFGVVGDLNQVVPQLTDEVVKRK
>NC_013595.1|WP_012894499.1|8940385_8941165_-|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MNIVVCVKQVPDTATERKLRSDDKTLDRDAADGVINELCEYAVEEALLLKEAHGGEVTVLTMGPDKASDTIRKALAMGADKAVHLVDDALHGSDALGTSYALAQTLRKIGFDLVVLGSESTDARTGVLAAMLAERLDVPQLTFANKVEVNGASIAIQRVTDYGYDKVEATLPAVVSVVEKINEPRYPSFKGIMAAKKKPVEKLGVADAEIDASQVGLANSWSEVADFAAAPPRAAGTIVKDEGDGGVKTADFLASKKFV
>NC_013595.1|WP_012894500.1|8941492_8942809_-|serine/threonine-protein-kinase
MGAPDGERLGPYHLLSTLGAGGFGEVHLALDPEGHTVAVKILHPHVAADRTALARLAREVETMRRVQGPYVAEVLDASLEGARPYLVTRYVQGRPLSAVVAGDGPVGGDDLVRLARGLAEALAAVHAAGVVHRDLKPANVILTDGEPVVIDFGIACALDSASVTVSGAILGTPGYLAPEVLEGADSGAEADLFSLGATLAYASTGRHPYGTGPPSAVGYRVVHHAPDLEGVPGWLEPLLQECLRRDPAARPSAAELLDRLGAAGPAVHTAIPRARPSTAATGGRGAVRGQEATHLQDAAPHEAGGGVQELTTRQWRPGRRPAPGRLSAEEARERRRAVLHRRWIVGTGLLVSLMAAAAREPLPEVSLLLLTSYGLVTLVDGGIALFGRRDRSRVVVDLAGAAGAIALWAVLGTFFSTLTLALALGTVVFVLVAILMAS
>NC_013595.1|WP_012894501.1|8942868_8944833_-|serine/threonine-protein-kinase
MTGDTQAPERLGPYRLLRKIGEGGMGVVHLGLDEDGREVAVKVLHPHVAADLKARDRLTREVETMRRVRSQQVAEVLDAELTGRQPYIVTRFAPGRTLEETVLADGPLAPGEVVRLAQGMCAALVAIHAADVIHRDFKPSNVMIVNGEPLVIDFGIAHLVNATRLTQTGMFVGTPGYLAPEIIRDTEITQAADVHALASTVFFGATGKPPFGTGSFEIVCFNIMEGRANIDLAPVWLRGWLRQALAVDPAVRPTAQALHRMARALDPSVTVFEETPPTTAVIDGGTRVLDSDGTKVINTDGTRVLDGQTQPPSPTTQPSPNGTRALPQDGSYSDLLTPVEYAKPERRERRPRGEPTRPSGATPPPYVPATPPPYVPAPSPEQRPRSAPPPYADQRVAGYPAPPPTGQARPYAPPAVQPRPHTPPQDRPRYRTGHPLAAVLLLAIIVGLACVLPVMVSAFALVTVLCLRVGEYLFGDLAERRSVRGNSATDPLLAVLGTPWALIKAVLATLVTAPLAAMFGMCVWGALVYIGQMKTDPAAAYAAGAFVAGLFVLPGGGKPRKAVSRALTGVIRSPGAAMVTTIVLGTLAFFSVMAALGMAPSFAPWDQPTDVVEAVKREWQTQVENGKMGVLDLIGGLVKDLMKSLGLGFLTFGK
>NC_013595.1|WP_169369475.1|8944829_8947016_-|protein-kinase
MNQDDRLGPYRLLRRLGEGGMGVVHLAVDPQGRQVAVKVLRAEVAGDDVARRRLSREVETMRRVRSEHIAEVLDADVTGHRPYIVTRYVPGQPLDELIKQDGPMELPALLKVAHGVAAALAAVHSVGVIHRDLKPGNVLILDGQPVLIDFGIAQAVDATRLTQTGMFIGTPGYLAPEIIEGHEAGPEVDVHAWAGTLVFAATGQPPFGKGTLEMIFYNITAGKADVDAVPAPLQPVLRAALQRDPAKRPRATELAAQVERLLSRAGRPRVPDEITTVSHFDDSGRSGHGGPGGQGFSGVPAGPVGQGFPAGPGGVGAPSRPGVQGFPTGPGVPGRAGDPGDVPTPIASRPGVSQQSTPWPPAPAAQPREYVSLLGEQPPDPSPTRRVTAEELRQAAAAQQASYDLPTGMLSPEDIPTRNRFPAGDPPGADQARPEAGRLEATAPVADGDIPTQRVRPQDLAEYIRGHTPQPGRPAQPGQVPQPYPPQQAAFEQTPHVRQPAPPPYSYPPRPQAQAPVTPHPGQRPGHMLQRSKAYGVASGMIMIIVAVAAVFAPIVVAAVAIPAVILLRAADIAQPRLNTRRAAGEAAADVFRVLGQPAALLKSVSITVALVPYALILGLPVTLLLTVVAVKMPPANALSWGTAVALWTVCAGPGVEGPGRQMRRTLASMLPSRSAAMIVASVLGALAALMILIAIGSVGNGARQARWAPVDVGTVVTELTDLRKAAR

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Crispr_ID: NC_013595_51

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_51

8936167-8936263

Orphan

Consensus_repeat	Method
GGCGCCTCAGCTGAGGCCCGCGGGGCGGGCGCGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_51

>merge|NC_013595|51|8936167-8936263|CRISPRCasFinder
GGCGCCTCAGCTGAGGCCCGCGGGGCGGGCGCGTCGTCCGTCGTACTGGCCGGACCTCGGGCAGGCGCCTCAGCTGAGGCCCGCGCGGCGGGCGCGT

>NC_013595|51|48|8936167-8936263|CRISPRCasFinder
GGCGCCTCAGCTGAGGCCCGCGGGGCGGGCGCGT	CGTCCGTCGTACTGGCCGGACCTCGGGCA
GGCGCCTCAGCTGAGGCCCGCGCGGCGGGCGCGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012894503.1\|8947147_8947669_-\|YbaK/EbsC-family-protein	unknown	unknown	gnl\|CDD\|240137
NC_013595.1\|WP_012894497.1\|8938144_8939335_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NC_013595.1\|WP_012894490.1\|8931210_8931507_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894484.1\|8922750_8923194_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NC_013595.1\|WP_169369475.1\|8944829_8947016_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012894494.1\|8934722_8935769_+\|DUF695-domain-containing-protein	unknown	unknown	gnl\|CDD\|368292
NC_013595.1\|WP_012894496.1\|8937509_8938016_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380063
NC_013595.1\|WP_012894493.1\|8933592_8934663_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_013595.1\|WP_012894487.1\|8929040_8929445_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NC_013595.1\|WP_012894501.1\|8942868_8944833_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012894499.1\|8940385_8941165_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|238847
NC_013595.1\|WP_012894505.1\|8949290_8950133_-\|M55-family-metallopeptidase	unknown	unknown	gnl\|CDD\|176450
NC_013595.1\|WP_012894498.1\|8939413_8940367_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NC_013595.1\|WP_012894488.1\|8929795_8930977_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_013595.1\|WP_012894504.1\|8947722_8949285_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224152
NC_013595.1\|WP_043653845.1\|8924922_8928921_+\|type-VII-secretion-protein-EccC	unknown	unknown	gnl\|CDD\|274858
NC_013595.1\|WP_012894491.1\|8931503_8932754_+\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|381605
NC_013595.1\|WP_043657857.1\|8923339_8924734_-\|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl\|CDD\|274855
NC_013595.1\|WP_012894492.1\|8932846_8933488_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|316044
NC_013595.1\|WP_012894500.1\|8941492_8942809_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012894503.1\|8947147_8947669_-\|YbaK/EbsC-family-protein	gnl\|CDD\|240137	cd04939, PA2301, PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, and ProX. The primary function of INS is to hydrolyze mischarged cysteinyl-tRNA(Pro)'s, thus helping ensure the fidelity of translation. Organisms whose ProRS lacks the INS domain express a single-domain INS homolog such as YbaK, ProX, or PrdX which supplies the function of INS in trans.	1.26381e-71
NC_013595.1\|WP_012894497.1\|8938144_8939335_+\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.99692e-67
NC_013595.1\|WP_012894499.1\|8940385_8941165_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	9.77055e-91
NC_013595.1\|WP_012894484.1\|8922750_8923194_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	0.000353483
NC_013595.1\|WP_169369475.1\|8944829_8947016_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.22658e-86
NC_013595.1\|WP_012894493.1\|8933592_8934663_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_013595.1\|WP_012894496.1\|8937509_8938016_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|380063	pfam17937, TetR_C_28, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in CgmR (C. glutamicum multidrug-responsive transcriptional repressor), previously called CGL2612 protein. CgmR (CGL2612) from Corynebacterium glutamicum is a multidrug-resistance-related transcription factor belonging to the TetR family. It regulates expression of the immediately upstream gene cgmA (cgl2611) by binding to the operator cgmO in the cgmA promoter. The cgmA gene encodes a permease belonging to the major facilitator superfamily, a protein family composed of bacterial multidrug exporters, and the pair of CgmR and CgmA confers multidrug resistance on C. glutamicum.	3.08931e-12
NC_013595.1\|WP_012894494.1\|8934722_8935769_+\|DUF695-domain-containing-protein	gnl\|CDD\|368292	pfam05117, DUF695, Family of unknown function (DUF695). Family of uncharacterized bacterial proteins.	2.86296e-06
NC_013595.1\|WP_012894487.1\|8929040_8929445_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	4.26336e-10
NC_013595.1\|WP_012894501.1\|8942868_8944833_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.42911e-78
NC_013595.1\|WP_012894505.1\|8949290_8950133_-\|M55-family-metallopeptidase	gnl\|CDD\|176450	cd08663, DAP_dppA_1, Peptidase M55, D-aminopeptidase dipeptide-binding protein family. M55 Peptidase, D-Aminopeptidase dipeptide-binding protein (dppA; DAP dppA; EC 3.4.11.-) domain: Peptide transport systems are found in many bacterial species and generally function to accumulate intact peptides in the cell, where they are hydrolyzed. The dipeptide-binding protein (dppA) of Bacillus subtilis belongs to the dipeptide ABC transport (dpp) operon expressed early during sporulation. It is a binuclear zinc-dependent, D-specific aminopeptidase. The biologically active enzyme is a homodecamer with active sites buried in its channel. These self-compartmentalizing proteases are characterized by a SXDXEG motif. D-Ala-D-Ala and D-Ala-Gly-Gly are the preferred substrates. Bacillus subtilis dppA is thought to function as an adaptation to nutrient deficiency; hydrolysis of its substrate releases D-Ala which can be used subsequently as metabolic fuel. This family also contains a number of uncharacterized putative peptidases.	1.86382e-128
NC_013595.1\|WP_012894498.1\|8939413_8940367_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	4.44894e-108
NC_013595.1\|WP_012894488.1\|8929795_8930977_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	9.26996e-26
NC_013595.1\|WP_012894504.1\|8947722_8949285_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|224152	COG1231, COG1231, Monoamine oxidase [Amino acid transport and metabolism].	6.56575e-75
NC_013595.1\|WP_043653845.1\|8924922_8928921_+\|type-VII-secretion-protein-EccC	gnl\|CDD\|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NC_013595.1\|WP_012894491.1\|8931503_8932754_+\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|381605	cd13402, LT_TF-like, lytic transglycosylase-like domain of tail fiber-like proteins and similar domains. These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	1.15702e-32
NC_013595.1\|WP_043657857.1\|8923339_8924734_-\|type-VII-secretion-integral-membrane-protein-EccD	gnl\|CDD\|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	3.35481e-41
NC_013595.1\|WP_012894492.1\|8932846_8933488_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|316044	pfam13483, Lactamase_B_3, Beta-lactamase superfamily domain. This family is part of the beta-lactamase superfamily and is related to pfam00753.	1.47252e-23
NC_013595.1\|WP_012894500.1\|8941492_8942809_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.43104e-84

>NC_013595.1|WP_012894494.1|8934722_8935769_+|DUF695-domain-containing-protein
MRLFGRKDEFTAEPADGIGEFWTWWAEARPELDAMVAAGEADRLAEWIGPAVQVVHPSLVWEIAPGLGSDQALVVTSAGDPELRPTAHRWAAAAPAADALWEFHPSRRANPHAMELTLDVGGYEFALDKLMLGLRAPLGNPRVDVVAYHPIFTILDDDTRIEAALLALDWLLGEDDVARWVGDISAAGFEPIDAVPAVHLPSVVADLASGYRDEQWALLEGETATGARLIATARYPLRPVDHPLFDQHIAITLPYLHGDADGLPVGRSLEALRDFEERLAGRISRLNGSAVFAAHMSAEGQRVLHVYADPVGDAAIHAKELIVSWEEGRPRVDVVGDPGWSAISPFLT
>NC_013595.1|WP_012894493.1|8933592_8934663_-|tRNA-2-thiouridine(34)-synthase-MnmA
MRLRVLAAMSGGVDSAVAAARIAEAGHDVTGVHLALSANPQSYRTGARGCCTIEDSRDARRAADVIGIPFYIWDMAERFHRDVVEDFVSEYAAGRTPNPCLRCNEKIKFEAVLDRALALGFDAVATGHHARIADGVLSRSPDEGKDQSYVLGVLTREQLKHAIFPLGDSTKAQVREEAARRGLMVADKPDSHDICFIADGDTRGFLADRLGAEQGPIVDESGAVVGRHEGAYGFTVGQRKGLHIDRPAPDGRPRYVLSIEPVSNTVTVGPRSALEVTGIVATRPVWNGPADVPHEPLTCTVQLRAHGEVYGCRAQLSGDEVHIALDTPATGVAAGQAAVLYLGDTVIGSATIATAA
>NC_013595.1|WP_012894492.1|8932846_8933488_+|MBL-fold-metallo-hydrolase
MKLTKFGHACVRLEKDGSVLVIDPGSFSEESALDGAQTVLITHEHFDHVEADRLRRAAEANPSLEIWTNEGVAATLTGVPAKIQVVRHGDTFDTAGFGVRVVGEWHAPNHPDMPIVRNVGFLVEEEVFYPGDAFTPPGVEVPTLLVPTNAPWMKASEMVEYLRQVRPARAFSTHDGLLNDIGLGLVDSWLGLESDRQKAEMRRLKPGESVTLP
>NC_013595.1|WP_012894491.1|8931503_8932754_+|transglycosylase-SLT-domain-containing-protein
MSDDRGSLTDRDGDREPIVPVVPGSSELLTIAMKVNGAKDSITTIANRWRTTAGDLNDHAIELTRAVNTVDHSWQGDSADAFDDYMRKYGKAGDALHLALADCAGALDTAAGALDTAETKVKTLTENLVTEWNTYRTNNSKNADGSTRTETELAAGIKPSVDTAVSNARLQLDSADKAVTQAAADLKTYMDERSIHFSDIPAVGDERFMAPDRVLHWEKTPLANPGQTTLAGTNGGNGGNGGNGSGGSGSGGDASGVIGSGGTSSGGTIPQPKEKVVGWIKEALTIIKSGKIDGFLARKGILEKVKDLDPNDPKDIERIWKIIFHESGGNPNAQNNWDINARNGVPSQGLMQTIPPTFAAWSPEGHKVIKDPVDNIIAGVLYTYGRYGSLAEHPGIASLERVDAQGRPDPGGYKPY
>NC_013595.1|WP_012894490.1|8931210_8931507_+|hypothetical-protein
MKNVDVHFDALDDCRTAAKKLMGKFGALAETYPAQSTDSSIFGRLTSSSALAAAVDGIEKTVDSEMGNVQSKLDGVEHALSTVAENLRNVKYPRVDSS
>NC_013595.1|WP_012894488.1|8929795_8930977_+|C40-family-peptidase
MSDDRGSLTDRDGDREPITPVVPGSSELLTIAMKVNGAKDSITTIAKRWRTTAGNLNDHAIELTRAVNTVDHSWQGDSADAFDDYMRKYRKAGDALHVALTDCAGALDTAAGALDTAETKVKTLTENLVTEWNTYRTNNSKNADGSTRTEAELAAGIKPSVDTAVSNARLQLDNADKAVTKATTDLKKYMDERSIHFSDIPAVGDQKFMAPDRVLHWEKTPLANPGQTTLAGTNGGNGGNGGNGASLSGSGGSGGNGPAGGDPGGPAQALPYVPGSGSGAAIVAAAQKHIGKPYVWGADGPSAFDCSGLVYYTLNQAGIKIGDTTAAGYQASGQPITPPPQPGDIVFFGDPATHVGIYAGEGKMIHAPRPGTMVRVEDVAGAAAGPITYRRFT
>NC_013595.1|WP_012894487.1|8929040_8929445_-|YbaB/EbfC-family-nucleoid-associated-protein
MNDEFRITMEGLADEYNKQAAQLRETYGKLNDLTATAQSDDRMVTVTVGPRGQVQGIELDPRVYRKLSPSELTHSIMEQIGVATGEVSARMQELMTPLVPDGLPYEELFGEGASFESFLPQPVNLPSREPEDRR
>NC_013595.1|WP_043653845.1|8924922_8928921_+|type-VII-secretion-protein-EccC
MSIVIVRRPERRPPPKPPRGEILLESPPEVPEVQPQGFMAVLTYLPMIAGGAAMGLMFTAGGNSNPLMYVASGLFAISMVGMSLGQMGRQSGERKNRLNNLRRDYFRYLSQVRKRVRQAAKQQRAALEWGGPAPESLWWVAMSQRLWERRPRDDDFGTVRLGTGVQKLAIQLIPPDSKPIEDLDALTSGALRRFVRAHSTVAKLPVAVALHSFARINLTGDPVAVRELVRAMIAQLTVFHSPDDMRVMVCASKEWMAQWDWVKWLPHALHPEETDAAGQVRLMAENLSQLDHLLGSELKERARFKPGASSDALPYHVLIIDGGHVPHDSQLGTDAIQGVTVIDLSGAAGPIEEKNTLRLDIQPDGFHMIKIDHAGKESSTRLGDPDRLDFLRTEGLARQLAPLRVSTAKGGETQDVLAMNTSLTDLLGVGDPTRLDASLTWRPRAGRNRLRVPIGLGVDGRLVELDIKESAQGGMGPHGLVIGATGSGKSELLRTLVLGLAITHSSEILNFVLVDFKGGATFLGLDTLSHVSAVITNLEDELPLVDRMYDALHGEMVRRQELLRAAGNYASLRDYERAREQGVDLKPMPTLFVVIDEFSELLSAKPEFIELFVMIGRLGRSLGVHLLLASQRLEEGRLRGLDTHLSYRVGLRTFSAMESRVVLGVADAYELPSAPGNGYLKFETTGMTRFKAAYVSGTYQADHSQGVTPDGQAILRQVVEYGPDFAPVPVVEEPKKELPAADGPADRGSVTLLDLVVSRLHDQGPPAHRIWLPPLGDPPSLTQLLPPLSATPELGLGTIGWVGRGQLHAVVGLVDKPFEQRSDPFWLDLSGAAGHVGVAGGTQSGKSTVLRTLIASMALMHTPREVQFYCLDFGGGALASLEGLPHLGGIASRLDGDRVRRTVAEIATLLQQREREFTDQGIDSITTYRRMRAEGTIEGDRFGDVFLVVDGWLTVRQEFETLEPVITDLAARGLGYGIHVVAATNKWSEFRPGIRDLFGTRVELKLGDAYESEVNRKASLAVPEGVPGRGLTREGLHFLSALPRIDGVQKADDLSDGVRALVHAVRDAWQGPPAPAVRLLPAVLAAETLPDAEQSGPNRIPLGIDEATLSPVMLDFDADPHFIVVGDTESGKSNMLRLITEGLVARHTPQQAMMIVIDYRRALLDSAATEHRIGYAASSAAALELIADVRNALLKRLPPADLTPEQLRSRSWWQGSDLYIVVDDYDLVATSSNPLQPLADLLPQARDIGLHLVMSRAMGGVGRAMFDPIIQKIKDMASPAVVLSGNKDEGFVFGNVRPHPLPPGRGYFVDRRHGARLVQTAFVAPPSPPEES
>NC_013595.1|WP_043657857.1|8923339_8924734_-|type-VII-secretion-integral-membrane-protein-EccD
MAQFAAPLPTLCHVTIVAPRRKADLALPADIPLPHVLPGLLRAVGEIGGDASAGPGWVLQRLGGAPLDLGQSLGTLGVLDGEVLYLRPQEAMLPPALFDDVADVVATGVQEGSDKWGPRHTRLAGVGAAVALLLTGVAALVLAGPPWTPAAVVAVVFAALLVAAGAAMSRAAGDSPAGALIGYAALPYGLLAGLLAPSAAGGLGGLGAAHMLAAFASVGLVATIAVIAIADGVPVFLGAAIASMTGAVSAAVVMVSQAPAAGVAAVTVAILLGFTPLIPVLSFRLARVPTPTMPTTADELRNDNQQIDGPLVEERTAHALSYATGMVAGVALVALVAQAYLVMHGGWVATANALTLSLTLIMRTRVFHGFGQRLWLMISGVSGLVMFAISQAAGGGGPTAIIVVMGLLGAAAICAGLGMWLQVGKPSPFWGRAGDIVELLLIVALFPLALGVLEVYSWVRGLSG
>NC_013595.1|WP_012894484.1|8922750_8923194_-|YbaB/EbfC-family-nucleoid-associated-protein
MQEFGDFANIDIDKLLKGADEQFARMEEMQKGMADLVGRAQDDDGLVTVEYAAEGIRELQLHPKAMRLSAGELAEKVKDVIAAATTDLQKQVNEVMAEVFGEEDNPMSYINDPDKAMNQIKDAEAAYNRTFDDVMGELDSIRRRMNL
>NC_013595.1|WP_012894496.1|8937509_8938016_+|TetR-family-transcriptional-regulator
MRREELLDAAEDLLCDQGSQALTLAAVAERAGCSKGGLLYHFSSKEALIKGMVERLIEDFDQLIAAQGHDTYTKNYLAATFAAVQSGRLRRWAVVTGASGNLYLLAPLRVAMARWHREGLGSEPDPAAAQIVRLACEGLWDVATHDPDLYDDDHYAELKRRLLDLLPA
>NC_013595.1|WP_012894497.1|8938144_8939335_+|MFS-transporter
MTRDLRTARIGAVLTFVLAGLLCGTMTVRIPALSDKLGLSEGSIGVTLLVWGLGALVTMQSMRGVMTRFGSRSILRVGAPLCAATLALLAFAPTFPLLLVAAGLFGMAFGAVDIAMNAQGSAVERAYGRPLMNGMHAGWCVGAISAGLLGTAAIAAGLSFTAHLALIALLTLPLLVIVSRTYLPDPAVTTGGEARARHRMPPVVYLLGVIAFCAFMVEGTVADWNGLYLRNVLGAPEALAALGYPIFEAGMLLGRLTGDRVRARFGARGMIITSGLATAVTFTVVITASTALVALSAMFFVGIAVATVSPMAMSLAGGAVDNPGPAIAQTGAMGYAGLLLGPVIIGFLSDVATLGTALGIAVVLGVVIALVARFLPRSLRDATPAETPERELSMAA
>NC_013595.1|WP_012894498.1|8939413_8940367_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MSEILVLVEHVEGQVKKVTLELLTLARKLGTPSAVWAGPGYSPDAKARLAEYGAEKIYVADSADISDYVVAPKAELLAQLVSEKSPAAVLVAATAEAKEIAGRLAIKIDSGLLTDVVGLQDGLVADQSIFGGGVNVQSRVTKGTPIVAVRPNSTPVEAAAGAGAEEQVSVTVSAAARGAKVVDRVKEEKGARPELTEAAIVVSGGRGVGSAENFSIIEKLADSLGAAVGASRAATDAGWYPHQFQVGQTGKTVSPQLYIAAGISGAIQHRAGMQTAKTIIAINKDAEAPIFELADFGVVGDLNQVVPQLTDEVVKRK
>NC_013595.1|WP_012894499.1|8940385_8941165_-|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MNIVVCVKQVPDTATERKLRSDDKTLDRDAADGVINELCEYAVEEALLLKEAHGGEVTVLTMGPDKASDTIRKALAMGADKAVHLVDDALHGSDALGTSYALAQTLRKIGFDLVVLGSESTDARTGVLAAMLAERLDVPQLTFANKVEVNGASIAIQRVTDYGYDKVEATLPAVVSVVEKINEPRYPSFKGIMAAKKKPVEKLGVADAEIDASQVGLANSWSEVADFAAAPPRAAGTIVKDEGDGGVKTADFLASKKFV
>NC_013595.1|WP_012894500.1|8941492_8942809_-|serine/threonine-protein-kinase
MGAPDGERLGPYHLLSTLGAGGFGEVHLALDPEGHTVAVKILHPHVAADRTALARLAREVETMRRVQGPYVAEVLDASLEGARPYLVTRYVQGRPLSAVVAGDGPVGGDDLVRLARGLAEALAAVHAAGVVHRDLKPANVILTDGEPVVIDFGIACALDSASVTVSGAILGTPGYLAPEVLEGADSGAEADLFSLGATLAYASTGRHPYGTGPPSAVGYRVVHHAPDLEGVPGWLEPLLQECLRRDPAARPSAAELLDRLGAAGPAVHTAIPRARPSTAATGGRGAVRGQEATHLQDAAPHEAGGGVQELTTRQWRPGRRPAPGRLSAEEARERRRAVLHRRWIVGTGLLVSLMAAAAREPLPEVSLLLLTSYGLVTLVDGGIALFGRRDRSRVVVDLAGAAGAIALWAVLGTFFSTLTLALALGTVVFVLVAILMAS
>NC_013595.1|WP_012894501.1|8942868_8944833_-|serine/threonine-protein-kinase
MTGDTQAPERLGPYRLLRKIGEGGMGVVHLGLDEDGREVAVKVLHPHVAADLKARDRLTREVETMRRVRSQQVAEVLDAELTGRQPYIVTRFAPGRTLEETVLADGPLAPGEVVRLAQGMCAALVAIHAADVIHRDFKPSNVMIVNGEPLVIDFGIAHLVNATRLTQTGMFVGTPGYLAPEIIRDTEITQAADVHALASTVFFGATGKPPFGTGSFEIVCFNIMEGRANIDLAPVWLRGWLRQALAVDPAVRPTAQALHRMARALDPSVTVFEETPPTTAVIDGGTRVLDSDGTKVINTDGTRVLDGQTQPPSPTTQPSPNGTRALPQDGSYSDLLTPVEYAKPERRERRPRGEPTRPSGATPPPYVPATPPPYVPAPSPEQRPRSAPPPYADQRVAGYPAPPPTGQARPYAPPAVQPRPHTPPQDRPRYRTGHPLAAVLLLAIIVGLACVLPVMVSAFALVTVLCLRVGEYLFGDLAERRSVRGNSATDPLLAVLGTPWALIKAVLATLVTAPLAAMFGMCVWGALVYIGQMKTDPAAAYAAGAFVAGLFVLPGGGKPRKAVSRALTGVIRSPGAAMVTTIVLGTLAFFSVMAALGMAPSFAPWDQPTDVVEAVKREWQTQVENGKMGVLDLIGGLVKDLMKSLGLGFLTFGK
>NC_013595.1|WP_169369475.1|8944829_8947016_-|protein-kinase
MNQDDRLGPYRLLRRLGEGGMGVVHLAVDPQGRQVAVKVLRAEVAGDDVARRRLSREVETMRRVRSEHIAEVLDADVTGHRPYIVTRYVPGQPLDELIKQDGPMELPALLKVAHGVAAALAAVHSVGVIHRDLKPGNVLILDGQPVLIDFGIAQAVDATRLTQTGMFIGTPGYLAPEIIEGHEAGPEVDVHAWAGTLVFAATGQPPFGKGTLEMIFYNITAGKADVDAVPAPLQPVLRAALQRDPAKRPRATELAAQVERLLSRAGRPRVPDEITTVSHFDDSGRSGHGGPGGQGFSGVPAGPVGQGFPAGPGGVGAPSRPGVQGFPTGPGVPGRAGDPGDVPTPIASRPGVSQQSTPWPPAPAAQPREYVSLLGEQPPDPSPTRRVTAEELRQAAAAQQASYDLPTGMLSPEDIPTRNRFPAGDPPGADQARPEAGRLEATAPVADGDIPTQRVRPQDLAEYIRGHTPQPGRPAQPGQVPQPYPPQQAAFEQTPHVRQPAPPPYSYPPRPQAQAPVTPHPGQRPGHMLQRSKAYGVASGMIMIIVAVAAVFAPIVVAAVAIPAVILLRAADIAQPRLNTRRAAGEAAADVFRVLGQPAALLKSVSITVALVPYALILGLPVTLLLTVVAVKMPPANALSWGTAVALWTVCAGPGVEGPGRQMRRTLASMLPSRSAAMIVASVLGALAALMILIAIGSVGNGARQARWAPVDVGTVVTELTDLRKAAR
>NC_013595.1|WP_012894503.1|8947147_8947669_-|YbaK/EbsC-family-protein
MAIGTLDWVRAAERLDLLAEPVARAVAGLDGVEVAEIDPTLADTAAFCERYGVSLAESANCVIVAAKRGGEVRYAACMVLATTRVDVNGVVRRHLDARKISFASQDDAVGLTGMEYGGITPLGLPEGWPVLVDEAVAAHPGVVIGSGVRHSKLALPGAVLADLKIAEVLRMAN
>NC_013595.1|WP_012894504.1|8947722_8949285_-|FAD-dependent-oxidoreductase
MSDSKVMTRRALLVGVGAAGGAGAMFAAMGALGLAPDAQEKDFVPPQPSDFSLRGRAAAKVVILGAGVAGLTCAYELGKAGYDCTVLEAADRVGGRNLTLRRGDRLPETGGETQTAEFEEGTYFNAGPGRIAQWMVALDYCRELGVPIETFVNNNASAYVYTGGMKAPARARTARADLYGYVAELLAKATHAGALNRRLTKDDRERLSEFLRRFGDIGPDLTYRGSTRRGFETYPGVTGGVPAGTPPSLSDVLSAGTGRALTMDFGYEQAMPMFQPVGGMDAIVTALAGAVGRDRIRTGARVTGVKNLPDGVEVAYQGGTLRADYCIATLPPHLLARLPHNLGAPITAALRTPVPVAAGKIGLEYGRRWWEIDDRIYGGITETDLDITHIWYPSHGYHSRSGLVVGYYNTEENAELYGGLPHRDRRGRALTQGKKIHGEKYRAELRSSVSIAWQRQPHIEGGWVYWPSHQGAFTLLQRPAGRVYFAGDWLTHLIAWQAGAMESARKAVTELHGRVLQTTS
>NC_013595.1|WP_012894505.1|8949290_8950133_-|M55-family-metallopeptidase
MKVYVSVDMEGVTGLTDPEEMHAGGRGYERGCELMTGDANAVIQGAFDAGAEAVRVNDAHGSVKNLRIDLLDERATLIRGPGKPLRMGQGLDPSYRAACFAGYHARAGVQHGVLNHTWMGKEIQNVYLNGEVCGETRLVASFAGSLGVPVALVTGDEAVCEEARELLGDVETVAVKKGVDRFSAELLPPAVAQARIREAAARALNRVADFRPCAPEPPFTLGVEWNSTAIAAGCALIPGVRSAGPRHTEFVTDDFSQIMALMGIFSMVGGQIACGSGVYG

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Crispr_ID: NC_013595_52

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_52

9071409-9071509

Orphan

Consensus_repeat	Method
GGTGGAAGGTCAAAAGCGCGGCGAGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_52

>merge|NC_013595|52|9071409-9071509|CRISPRCasFinder
GGTGGAAGGTCAAAAGCGCGGCGAGGGGTGGGTGGAGTGGCCCAGGGCCGGCCCTTTCGTGCGGCGCCGTATGGGGTGGAAGGTCAAAAGCGCAGCGAGGG

>NC_013595|52|49|9071409-9071509|CRISPRCasFinder
GGTGGAAGGTCAAAAGCGCGGCGAGGG	GTGGGTGGAGTGGCCCAGGGCCGGCCCTTTCGTGCGGCGCCGTATGG
GGTGGAAGGTCAAAAGCGCAGCGAGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012894611.1\|9081123_9082176_+\|prenyltransferase	unknown	unknown	gnl\|CDD\|273702
NC_013595.1\|WP_012894608.1\|9077751_9078780_-\|GDP-mannose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|224014
NC_013595.1\|WP_174435307.1\|9079075_9080302_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340831
NC_013595.1\|WP_148269355.1\|9063769_9066898_+\|glycoside-hydrolase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379625
NC_013595.1\|WP_012894604.1\|9072660_9074499_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_013595.1\|WP_012894612.1\|9082240_9085867_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375009
NC_013595.1\|WP_012894593.1\|9059433_9060495_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380478
NC_013595.1\|WP_012894601.1\|9069102_9069552_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NC_013595.1\|WP_012894596.1\|9062661_9063507_-\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NC_013595.1\|WP_012894595.1\|9061369_9062665_-\|L-fuconate-dehydratase	unknown	unknown	gnl\|CDD\|239440
NC_013595.1\|WP_012894594.1\|9060630_9061377_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NC_013595.1\|WP_012894610.1\|9080348_9081062_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NC_013595.1\|WP_012894607.1\|9077229_9077580_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894598.1\|9067126_9068332_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NC_013595.1\|WP_012894600.1\|9068503_9069082_-\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|379205
NC_013595.1\|WP_012894605.1\|9074654_9075878_-\|glycosyl-transferase	unknown	unknown	gnl\|CDD\|273616
NC_013595.1\|WP_012894599.1\|9068324_9068468_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_148269356.1\|9071656_9072514_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NC_013595.1\|WP_012894602.1\|9070207_9071188_-\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|223220
NC_013595.1\|WP_169369483.1\|9076516_9077038_+\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|341130

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012894611.1\|9081123_9082176_+\|prenyltransferase	gnl\|CDD\|273702	TIGR01577, Uncharacterized_glycosyl_hydrolase_MJ1610, oligosaccharide amylase. The name of this type of amylase is based on the characterization of an glucoamylase family enzyme from Thermoactinomyces vulgaris. The T. vulgaris enzyme was expressed in E. coli and, like other glucoamylases, it releases beta-D-glucose from starch. However, unlike previously characterized glucoamylases, this T. vulgaris amylase hydrolyzes maltooligosaccharides (maltotetraose, maltose) more efficiently than starch (1), indicating this enzyme belongs to a class of glucoamylase-type enzymes with oligosaccharide-metabolizing activity.	5.16414e-05
NC_013595.1\|WP_012894608.1\|9077751_9078780_-\|GDP-mannose-4,6-dehydratase	gnl\|CDD\|224014	COG1089, Gmd, GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane].	1.59536e-176
NC_013595.1\|WP_174435307.1\|9079075_9080302_+\|glycosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	1.58827e-56
NC_013595.1\|WP_148269355.1\|9063769_9066898_+\|glycoside-hydrolase-N-terminal-domain-containing-protein	gnl\|CDD\|379625	pfam14498, Glyco_hyd_65N_2, Glycosyl hydrolase family 65, N-terminal domain. This domain represents a domain found to the N-terminus of the glycosyl hydrolase 65 family catalytic domain.	3.80219e-73
NC_013595.1\|WP_012894612.1\|9082240_9085867_-\|hypothetical-protein	gnl\|CDD\|375009	pfam17132, Glyco_hydro_106, alpha-L-rhamnosidase.	0.00164833
NC_013595.1\|WP_012894604.1\|9072660_9074499_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.72342e-79
NC_013595.1\|WP_012894601.1\|9069102_9069552_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	4.10886e-08
NC_013595.1\|WP_012894596.1\|9062661_9063507_-\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.67314e-96
NC_013595.1\|WP_012894595.1\|9061369_9062665_-\|L-fuconate-dehydratase	gnl\|CDD\|239440	cd03324, rTSbeta_L-fuconate_dehydratase, Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to mediate the down-regulation of thymidylate synthase protein by a novel intercellular signaling mechanism. A member of this family, from Xanthomonas, has been characterized to be a L-fuconate dehydratase. rTS beta belongs to the enolase superfamily of enzymes, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	0
NC_013595.1\|WP_012894594.1\|9060630_9061377_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.03141e-67
NC_013595.1\|WP_012894593.1\|9059433_9060495_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380478	cd01536, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of active transport systems that are members of the type 1 periplasmic binding protein (PBP1) superfamily. Periplasmic sugar-binding domain of active transport systems that are members of the type 1 periplasmic binding protein (PBP1) superfamily. The members of this family function as the primary receptors for chemotaxis and transport of many sugar based solutes in bacteria and archaea. The sugar binding domain is also homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR. Moreover, this periplasmic binding domain, also known as Venus flytrap domain, undergoes transition from an open to a closed conformational state upon the binding of ligands such as lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. This family also includes the periplasmic binding domain of autoinducer-2 (AI-2) receptors such as LsrB and LuxP which are highly homologous to periplasmic pentose/hexose sugar-binding proteins.	7.24018e-55
NC_013595.1\|WP_012894610.1\|9080348_9081062_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.75594e-26
NC_013595.1\|WP_012894598.1\|9067126_9068332_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.60806e-99
NC_013595.1\|WP_012894600.1\|9068503_9069082_-\|PIN-domain-containing-protein	gnl\|CDD\|379205	pfam13470, PIN_3, PIN domain. Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).	6.93652e-12
NC_013595.1\|WP_012894605.1\|9074654_9075878_-\|glycosyl-transferase	gnl\|CDD\|273616	TIGR01426, Glycosyl_transferase, glycosyltransferase, MGT family. This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance].	5.01719e-151
NC_013595.1\|WP_148269356.1\|9071656_9072514_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	4.31786e-06
NC_013595.1\|WP_012894602.1\|9070207_9071188_-\|polyprenyl-synthetase-family-protein	gnl\|CDD\|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	1.83855e-68
NC_013595.1\|WP_169369483.1\|9076516_9077038_+\|L,D-transpeptidase-family-protein	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	6.01713e-22

>NC_013595.1|WP_012894602.1|9070207_9071188_-|polyprenyl-synthetase-family-protein
MLAHVARPEEILNSPAVSAGLLRVEKRIHRLSTSSRLPLINGAAGRITGAGGKRLRAALTLATALALGGRIDNRVVTAAACVELIHAGSLVHDDLMDKAAERRGVRTLNAELGDARALVVGDFMLARAGLAALSVVSKPVARTLASVVVELAEGQFQEVAELFDPGRTPEDALRSITGKTAALFRASCLVAHPDGRSMAEYGERFGVLFQILDDLLDLASTAERLGKPVGNDIRQGVYTLPLLLALQHDHGDLRPLLGRRLSEDEITALLTRLRGGRMVDDTLEYCRGLASDALSSLPVIADPEIAAALYGLPAACIDWTESLLVR
>NC_013595.1|WP_012894601.1|9069102_9069552_-|helix-turn-helix-domain-containing-protein
MSRPGVLAHATRVEPVNADREVLAELQAADRPQTQLVLRGSGGRDIVLPEGLVRLVLAAAQDLAAGNAVLALPVETRLTPNEVAQLLGVSRPFVARLLDEGEIPSQYLPDSRHRLVRLSDVVEFQARRERRAEGRRRITEVAEEADLPY
>NC_013595.1|WP_012894600.1|9068503_9069082_-|PIN-domain-containing-protein
MARVFVDTNVLFPFSLMDLMLALTEDAVHTVVWSDHLLDEWERVIVRERHRSTAAAARISAAMREFFADTRVSEDDYKHVLEHLDGPDPDDCHHMAAAIVGRAQTMVTWNLTDFPVATLSRYGLTVTDPDTYLCSLLAQSPHEVVAVLARMAKGKRRPPMTGLDITHALERAGVPVFARRARNRLPAVSDEP
>NC_013595.1|WP_012894599.1|9068324_9068468_-|hypothetical-protein
MFGSALAFGESVIQDSRALPDRAAVIAAALYGLPAACIDWTESLLVR
>NC_013595.1|WP_012894598.1|9067126_9068332_+|cytochrome-P450
MDINLVDQDFYWQNGAPHDQLAWLRANAPVYPHPGDAERGWPGFWAVTGHADVVHVSRRSDLFSSSRKLALFDEMPEDQRALQRMMMLNQDPPEHTRRRSLVNRGFTPRMMGALEQHIRDICHELVDEAKGRGSADFVRDIAAPLPLYVICELLGAPVEDRDKIFNWSNQMIGAEDPDYAADSSGGPDAAMQVYAYANALAAERRERPREDIVTKLIMPDAAGETLTEEEFDLFVLLLVVAGNETTRNAASGGMLAFFEHPEQWERLVADPALARTAADEIVRWVSPVNLFRRTATADTTIGGQEVKEDDKVVVFYSSANRDEKIFADPGVFDIGRDPNPHIGFGGGGAHFCLGNHLAKLELRVLFEVLAERLPGLTQAGPARRLRSNFINGIKDLPVTLT
>NC_013595.1|WP_148269355.1|9063769_9066898_+|glycoside-hydrolase-N-terminal-domain-containing-protein
MSLVTAGFRCYLLEVGRPCDRRNRLSHPPRRRLGITLLATLTLTTCLYGQNMANAEPEKSAAAVQTPDDLTLWYDKPATNWETQALPIGNGALGAMVFGGVASEQIQFNEKTLWTGGPGSGGYNAGNWTSPRPNAIAEVQAQIDRDGRMSPSAVTAKLGQPKSGFGAYQTFGDLWLDVPDAPASPTGYRRELSLREAVARVGYTAGGVTYSREYFASHPGGVIVGRISASQAGKVSFTLRTSSPRSDKQVSVANGRLTVRGTLADNGMRFESQIQVVTQGGSRTDGTDRVTVTGADSAMFVLSAGTDYAGTHPAYRGPDPHAKVTAAVDAAAARTFDQLRTAHQNDYRKLFDRVRLDLGQRVPAIPTDRLRAAYTGRASADDRALEAMFFAYGRYLLISSSRDEALPANLQGVWNNSTSPPWSADYHVNINLQMNYWLAEQTNLAETTVAYDRYIKAMVAPGRKTAQEMFGSRGWVVHNETNPFGFTGVHDWATAFWFPEAAAWVTQQMYDHYRFNGDTAYLRDTAYPVMKGAAEFWLDNLHADPRDGKLVVSPSYSPEQGDFSAGASMSQQIVFDVLTNSLEAARKLNVDPAFQAEVTAALAKLDRGIRVGSWGQLQEWKSDWDDRANTHRHVSHLFALHPGRQIVAGTPEATAAKVSLTARGDGGTGWSKAWKVNFWARLLDGDHSHKMLSEQLKTSTLDNLWDTHPPFQIDGNFGATSGVAEMLLQSQHDTIHVLPALPSAWPTGSVTGLRARGDVTVDVSWRNGSGERITLRPGRTGAVKVRSALIAGRHRVQDETGATVGAVRDGETLTWNAQAGKTYTIVDDDGATPCAPAPADRPVVAWDPTSGTAVADASGNGRNATVSGTAAYDASAPTGSGLVLGGSTYLTTGNTTLGFLREATFAAEVKVGGSGYRRLFDSQPSGNPGTDGVIVDITPANKLRFIGAGLNVTTDATVPTGRYVDLVVTMDRTGAVTVYVDGARIGGGTATTAGITGCASRPLRFAADQGGGQRLTGAVDRMAILPRALTAAEIGTWRDLAF
>NC_013595.1|WP_012894596.1|9062661_9063507_-|fumarylacetoacetate-hydrolase-family-protein
MKLLRVGPVGQERPAVMDEAGNLRAISEPEIDGAFLASGGVARVREALERDELPVLESEGLRIGPPVARPGKIVCIGLNYRDHAEETGAPIPAEPIIFMKAPNTVVGPYDEVLIPRDSVKTDWEVELAVVIGRTVRYAETREEALAAVAGYAISNDVSEREFQLERGGQWDKGKSCETFNPLGPWLVTADEIADPQALGLRLWVDGEPYQNGDTKNMIFHVAEVVRYLSRFMVLEPGDVINTGTPAGVALGLPGTPYLRAGQVMELEIDGLGRQRQTVGQA
>NC_013595.1|WP_012894595.1|9061369_9062665_-|L-fuconate-dehydratase
MSAYRITALETHDIRFPTSLELDGSDAMNPDPDYSAAYLVLKTDDGFEGHGFAFTIGRGNEVQTAAIKALEPYVVGKDVEDLGALWKDMVHDSQLRWLGPEKGVMHMAISAVVNALWDLKAKREGKPLWLLLAEMSPEEIVALVDFRYLSDALTPQEALEILRAAEPGRRERIAHLREHGYPAYTTSPGWLGYSDDKLRRLCKEAMAEGFTQIKLKVGADLEDDRRRMRIARETCGDDFPIAIDANQRWDVDSAIAWINALAEFRPHWVEEPTSPDDVLGHAAIARGIAPIPVATGEHVQNRMVFKQLLQAEAISYLQIDAARVAGVNENIAILLLAAKFGVPVCPHAGGVGLCELVQHLSMFDYVAVSGSMENRVIEYVDHLHEHFADPVVIKNGAYVAPSLPGFGAAMHPRSITDHTYPDGPVWRSLNG
>NC_013595.1|WP_012894594.1|9060630_9061377_-|SDR-family-oxidoreductase
MAEFDGLRALVTGGGSGIGLATATLLAARGAAVACLDLNPPGEPFVPVRADVTDEDAVRTAVAEAAERMGGLDILVNNAGIGAAGTIEDNPYEEWSRVLDVNVLGIVRVTRAALPHLRRSANAAIVNTCSIAATAGLPQRALYSASKGAIQSLTLAMAADHVREGIRVNCVNPGTADTPWVQRLLDAAADPAAERAALEGRQPMGRLVSAEEVAAAIAYLASPLAASTTGAAVAVDGGMQGLRLRPAT
>NC_013595.1|WP_012894593.1|9059433_9060495_-|sugar-ABC-transporter-substrate-binding-protein
MKLGTAATGAALLALALTVSACGSSETTGADSSAKPAADAGAKGGKVGIDFPRADSDFWNSYNKYVPQLAGELGVDLMPPTNSQNDVAKLVANTQAMMGQGAKAIIMAPQDTGAIASTLQTLENKNIPVVSVDTRPDKGKVFMVVRADNKAYGTKACEFLGEKLGGKGKVVQLMGALSSINGRDRAEAFGACMKEKFPGITVFEEPTEWDGTKAASMLQTRLQQHPDVKGIYMHAGGVHLAPTLQVLKAKGLIAPPEDPKHVFVISNDGIPQEFEAIRKGEIDATLSQPADLYAKYALFYAKAAIEGKTFQPGPTDHDSTIVQLPNGLEDQLPAPLVTKENVDDKSLWGNQVK
>NC_013595.1|WP_148269356.1|9071656_9072514_-|GNAT-family-N-acetyltransferase
MTDMHVRDATIGDLETIATVAVAAGQDEEWTGADPAYVGHLLSCGRVVVAEHRGAVTGFGAIRRIGSGPEETTMLCDLFVDPRSHGLGAGRAMLAALWRDGSRRMTFSSVHSHALPLYTRSGLDGWWPLLYLDGDVRALGVPGGWAVSAAEPGEVAELEERWTGIDRAADHRAWAARPSGQAVVAGRDGETLAAGTVAGAGTEYGIVHLATAPHADADAVRDAVVAVLASLDPPGGRARVCLPAPHQATRPLLAAGWRNDSFDLFMATDPGLLDPRRAVPSPALA
>NC_013595.1|WP_012894604.1|9072660_9074499_-|protein-kinase
MSGPGSLAADDPERIGGCRLTGVLGDGGQGVVYRGRDPSDRQVAVKLLHVRMAADPTVRRRFIREAEVTRRVAAFCTAQVLDLGIAGDRPYLVSEYIPGPSLRELVTGDGPRTGSGLDRLAVATLTALAAIHRAGIVHRDFKPDNVIMGPEGPVVIDFGIARVLDGTTTSSGLVGTPAYLSPEQLDGHQAGTASDVFSWAATMVFAATGHRAFPGDVAAAVMNAVSNREPDLAGVPERLRPLLAACLAKDPAARPAVTGLLATLTHGEPTPVDHRPSPPAEPPLSRAPSSPATSPASRVPSPPVEPSVSRAPSSPATPSASRLPRRPARRRLLAAGAAVTVLPLVAGAFWLWQPELPGISGPSPTGPSATSAPTPDRSPSTIPLGMPVGRPFTVRTDPSWSVEAVTELKGRQVVVSGGDSTVRVWDLATRKETGRPFTAHNTGAHAVVTELEGRQVVVSGGGDSAVRVWDLATRKETGRPFTAHNTGAHAVVTELEGRQVVVSGGGDSAVRVWDLATRKETGRPFTAHNTGAHAVVTELEGRQVVVSGGGDSAVRVWDLATRKETGRPFTAHNTGAHAVVTELEGRPVLLAADFDGKVRVWSLGQPAPAPGS
>NC_013595.1|WP_012894605.1|9074654_9075878_-|glycosyl-transferase
MPRRAHIAMVSIPAPGHVNPSLEVIRELAARGHRVTYANDPSFAEVIEGAGAEPVPYASTLPMNDPDGWPEDTIAQLDVFLNDSISMLPQLRAAYGDDRPDLFLYDIAGYSARILAENWGIPAMQLSPCYVAWEGYEEDTAPMVEQLKKAPGGAEHYRRFEQWLVDNGITGTDSQAFVGSPERALALIPRMMQPNADRVDPARITFTGPCLSARTHQEAWTRPESAEKVLLVSLGSAFTNLPGFYRSCLAAFGDLPGWHVVLQIGKFVDPAELGEIPANVEVHSWVSQLSILEQADAFVTHAGMGGTQEGLYCGVPMIAVPQGADQFDNADKIVELGAGRRIDAGQATPEALRTALLELTSDPEVALRLERISAEVRAEGGTTRAADLVERLLETAAPTPEGSLPAA
>NC_013595.1|WP_169369483.1|9076516_9077038_+|L,D-transpeptidase-family-protein
MAVLPPTQLEDPTWVPVVQTLPGWARILLPSRPNRSTGWIHTGDGGVRTARSTHRVRVDLAARRLRLFDAGRRTGSWAVAVGTDRTPTPAGRTFLLASVSPEHPTYSPLFLALGAHSGALRTFAGGPATIALHGWPDRAAFGREVSYGCVRVPAAALRALSRVPLGTPVMITR
>NC_013595.1|WP_012894607.1|9077229_9077580_-|hypothetical-protein
MTEQLTQIPITIDSEREDDAAAAGTYRLYWYGKGLKKTREEARAFAASRGEGHQLADLPSDVWRTSAATYLDGPAWIYSWKGDNYGDGNVVLHPNGAIGTMEDGAEQLPFLISYVG
>NC_013595.1|WP_012894608.1|9077751_9078780_-|GDP-mannose-4,6-dehydratase
MARRALITGITGQDGSYLAECLLSEGYEVWGLVRGQANPRVSRVRKLLQDVQLVRGDLLDQGSLISAVEKVQPDEVYNLGAISFVPMSWEQAELTAEVTGMGVLRMLEAIRVCSGISSSRTAAGSGQIRFYQASSSEMFGQVRETPQTEITPFHPRSPYGVAKAYGHFLTQNYRESYGMYAVSGILFNHESPRRGAEFVTRKVTLGVARIKLGLATELRLGNMEARRDWGYAGDYVRAMHLMLQADTPEDYVIGTGRTHSVRELVEAAFAAAGLDWERHVVGDQSLHRPAEVDLLCADPKKARVQLGWEPSVSFEELVAMMVESDVKLLSDGGDPEQDSSWP
>NC_013595.1|WP_174435307.1|9079075_9080302_+|glycosyltransferase
MRIALLSYRSKPTCGGQGVYLRHLSRELVALGHHVEVFSGQPYPELDEGVILNKVPSLDLYRDEDPFRTPKPHEYRDWIDCLEVATMWTAGFPEPLTFTLRAHRELKKRVGDFDVVQDNQTLGYGLLGIQKLFPVVGTIHHPISVDRRIELKAAPLRKKLSLRRWYGFVRMQAKVAPRLNPILTVSESSLADIHRDFNVPQANMRLIPLGVDTRYFHPRPEMPKRPGSIVAVASADSPMKGVSTLLRAVAKLATERDVNLTVVSKPTPGGPTEKLVAELSLHDRVTFVHGISDTALGELIATSEISVVPSLYEGFSLPAVEHMACGTPLVASRTGALPEVVGDAAVQVAPGDPEELAAVLRRLHDSPEERAAVGRKGYERAMERYTWNVVAQRTVEAYHEAIQARRAK
>NC_013595.1|WP_012894610.1|9080348_9081062_+|class-I-SAM-dependent-methyltransferase
MLTVDFGRLPVGPGTRVLDLGCGGGRHAFEVLRRGADVVAFDMDAEELEGVASMFAAMDKAGEVPPGATAETVTGDALKMPFEDASFDRVIAAEVLEHIPDDMAAMREIFRVLKPGGRAAITVPSFLPERICWALDEAYHTAPGGHVRIYTLAELSAKLKSIGMEIGPHHHAHGLHAPYWWIKCAVGVNNDDHPLAKAYHEILVWDIMKRPAATRIAEAVLNPLIGKSVVLYVRKPA
>NC_013595.1|WP_012894611.1|9081123_9082176_+|prenyltransferase
MSDQLRWEQVVQTAQSIAAVQESDGGIPWPEGHVDAWNHVECLMAMSVAGLTGPVRKGYDWLVRTQRADGSWPMKLVGGRAVEQGGESNHAAYVAVGAWHELLVTGDEDFAREMWPVVRSALDFVVELQTTRGEIVWERAADGRPARYALLTGCASIYQGLRSGVLLGEQLSDPQPDWELAADQLGHVLAAHPEAFADKSRFSMDWYYPILGGAVRGPAARARLAEEWDTFVEPGLGIRCVSDQPWVTGAESCELVLTLDAVGDRDRALKLFADMQHLRHEDGSYWTGWQFVNEKWFPHERSAYTAAAVVLAADALTEHTAASGIFRDAGRYVTDRPTSACGCSHAGSRA
>NC_013595.1|WP_012894612.1|9082240_9085867_-|hypothetical-protein
MNVFDALRNPPRSHSPAAIWWWSGEPLRRERLRWQMERLVAGGVHNLVILNLAPSGPLFGADADDPPFLSEAWWELLDGVCEDALQTGAYLWFYDQLGFSGADLQARLVQENPAFAGQWLDADGSVSLRGFDYLSRTACEVLLDRVHGEFARRLGHRFGNVIVGSFQDELPSMPTWSATFAEEFLARRGYPFSRDGGPSVRHDYQRTRAELAEEAFFRPLAEWHAEHGLLNGCDQQDPARAGHPVEGVELYADYTRTHRWFSAPGSDHHGDARVHSSLAHLYGRPRTWIEAFHSSGWGGTLEETFDWLLPWLRAGANLYNPHAVYYTTRAGWWEWAPPSTDWRQPYWRHHRVFADAVTRLCAVLSLGRHLCDVAVLFPAATAQAGGAGDGDAARAQRVYRELVGDMAWFQTVPGALDRLCLDADVIDEESVRRAVVSDGRLAVSTESYGVVILPAATVLDEGTAERLDGFVADGGLLVAVGALPDSPRLRRHFEGGPEGGPTAGPGEGPAGGSGRGSGAGRGRGAARLVASAADLGEALAGHVPRVEAPVPPLVREVDGTTVVFLTAAFPRASEIGVGRPEERGVELGWLDATCDFDSGRYRREMRVRVRDVTGTPLLASPFSGEVRPLPYTLDDGVVEVTVPFEDGPAALLLFPGQGTVPETGETAAPESRTPYTREIDLGDEWDMELVPTLDDTWGDFGTSATVERWTLETPDGDPVHATFGPHGLWRTGDGDWRPAVWSTSRGLHKDPIHRDTLGPKGHVPEEFLDFGPVPAGRPVWFRASVTVPGTPEARLVVGAAAAKEVRVDGRELPLDDSGYLAVGLSPVEPGEHVLELRLVPDEDLTLRAHVSFTADPGAARRPEWIAGPVLETVVRAGEGGEDGEHVLQIASTSPCMVLVNGTEAGRQGGFDPYAEADIPRVRRYDVSHLLRPGPNTVRVESDGAVLADGLVVSGPGWTSRPGVRRRQHGDPAALHLRPRPHPLPGAGWIDSRATALPAIFAVPGAAERVERFRVDVPPGATLMEADAHGPVRVLVDGVESALPAVLDGSARRAELLVTTRPGFQGGAALAGPVRFACGPGRIKLGDWEAQGLAGYSGGVRYRTVVRLPASPAGRPGLAGPGPAGERGRAELDLGRVRGTAEVTVNGRPAGVRVCWPYVFDLSLDEGENTVEILVLGTLAPYLDAVSPTHFVFPGQRVTGLFGPVLLRT

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Crispr_ID: NC_013595_53

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_53

9261657-9261783

Unclear

Consensus_repeat	Method
GCCCGAGGCCGACGTGGCCGACCAGCACCGCCCGGTGAACGAGGAC	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NC_013595_53

>merge|NC_013595|53|9261657-9261783|CRISPRCasFinder
GCCCGAGGCCGACGTGGCCGACCAGCACCGCCCGGTGAACGAGGACATCCCCGACTGGCCCGAGGAGATCTCGGCCGAGATGCCCGAGGCCGACGTGGCCGACCAGCACCGCCCGGTGAACGAGGAC

>NC_013595|53|50|9261657-9261783|CRISPRCasFinder
GCCCGAGGCCGACGTGGCCGACCAGCACCGCCCGGTGAACGAGGAC	ATCCCCGACTGGCCCGAGGAGATCTCGGCCGAGAT
GCCCGAGGCCGACGTGGCCGACCAGCACCGCCCGGTGAACGAGGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012894756.1\|9253951_9254800_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894765.1\|9262682_9262913_+\|DUF3107-domain-containing-protein	unknown	unknown	gnl\|CDD\|378634
NC_013595.1\|WP_012894766.1\|9263512_9264163_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|205967
NC_013595.1\|WP_012894753.1\|9251914_9252235_-\|MGMT-family-protein	unknown	unknown	gnl\|CDD\|376440
NC_013595.1\|WP_012894759.1\|9257356_9258538_-\|adenylyltransferase/sulfurtransferase-MoeZ	unknown	unknown	gnl\|CDD\|181156
NC_013595.1\|WP_012894771.1\|9269352_9270069_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NC_013595.1\|WP_148269370.1\|9261964_9262594_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_013595.1\|WP_012894760.1\|9258615_9259530_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|184875
NC_013595.1\|WP_148269832.1\|9252725_9253955_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|274856
NC_013595.1\|WP_081453333.1\|9264535_9266428_+\|DEAD/DEAH-box-helicase	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|223587
NC_013595.1\|WP_012894768.1\|9266548_9267421_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_013595.1\|WP_148269369.1\|9259835_9260144_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894757.1\|9255021_9256413_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|274856
NC_013595.1\|WP_012894754.1\|9252222_9252594_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894773.1\|9270859_9271501_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894762.1\|9260495_9261377_-\|Ku-protein	unknown	unknown	gnl\|CDD\|238408
NC_013595.1\|WP_174435309.1\|9268464_9269322_-\|PD-(D/E)XK-nuclease-family-protein	unknown	unknown	gnl\|CDD\|378929
NC_013595.1\|WP_148269368.1\|9256406_9257141_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043653941.1\|9270201_9270816_-\|MarC-family-protein	unknown	unknown	gnl\|CDD\|225006
NC_013595.1\|WP_012894769.1\|9267522_9268440_+\|DUF2236-domain-containing-protein	unknown	unknown	gnl\|CDD\|378343

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012894765.1\|9262682_9262913_+\|DUF3107-domain-containing-protein	gnl\|CDD\|378634	pfam11305, DUF3107, Protein of unknown function (DUF3107). Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.	5.17815e-30
NC_013595.1\|WP_148269370.1\|9261964_9262594_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.71152e-17
NC_013595.1\|WP_012894753.1\|9251914_9252235_-\|MGMT-family-protein	gnl\|CDD\|376440	pfam01035, DNA_binding_1, 6-O-methylguanine DNA methyltransferase, DNA binding domain. This domain is a 3 helical bundle.	7.66e-18
NC_013595.1\|WP_012894759.1\|9257356_9258538_-\|adenylyltransferase/sulfurtransferase-MoeZ	gnl\|CDD\|181156	PRK07878, PRK07878, molybdopterin biosynthesis-like protein MoeZ; Validated.	0
NC_013595.1\|WP_012894766.1\|9263512_9264163_-\|hypothetical-protein	gnl\|CDD\|205967	pfam13794, MiaE_2, tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like.	2.3098e-64
NC_013595.1\|WP_012894760.1\|9258615_9259530_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	6.81824e-29
NC_013595.1\|WP_148269832.1\|9252725_9253955_-\|S8-family-serine-peptidase	gnl\|CDD\|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	4.51652e-59
NC_013595.1\|WP_081453333.1\|9264535_9266428_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	3.30816e-135
NC_013595.1\|WP_012894768.1\|9266548_9267421_+\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	5.36454e-24
NC_013595.1\|WP_043653941.1\|9270201_9270816_-\|MarC-family-protein	gnl\|CDD\|225006	COG2095, MarC, Multiple antibiotic transporter [Intracellular trafficking and secretion].	7.4534e-43
NC_013595.1\|WP_012894757.1\|9255021_9256413_-\|S8-family-serine-peptidase	gnl\|CDD\|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	2.8273e-69
NC_013595.1\|WP_012894771.1\|9269352_9270069_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	2.80045e-31
NC_013595.1\|WP_012894762.1\|9260495_9261377_-\|Ku-protein	gnl\|CDD\|238408	cd00789, KU_like, Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku homologs are predicted to form homodimers. It is proposed that the Ku homologs are functionally associated with ATP-dependent DNA ligase and the eukaryotic-type primase, probably as components of a double-strand break repair system.	6.42285e-117
NC_013595.1\|WP_174435309.1\|9268464_9269322_-\|PD-(D/E)XK-nuclease-family-protein	gnl\|CDD\|378929	pfam12705, PDDEXK_1, PD-(D/E)XK nuclease superfamily. Members of this family belong to the PD-(D/E)XK nuclease superfamily.	3.58377e-23
NC_013595.1\|WP_012894769.1\|9267522_9268440_+\|DUF2236-domain-containing-protein	gnl\|CDD\|378343	pfam09995, DUF2236, Uncharacterized protein conserved in bacteria (DUF2236). This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	2.05892e-58

>NC_013595.1|WP_012894762.1|9260495_9261377_-|Ku-protein
MRSIWKGTVSFGLVTIPVRLFTATERRDVTFHLVHGEDGGRIRFRRFCQACEEEVPFADVAKGYELPGGDMVVLAGDDFDDLPLSTSRRIEVLQFSPAGQIDPILLDKAYYLEPDPAGVKPYVLLRDALERSGLVAVVKVALRQRESLAALRVRDGVFLLETMLWPDEVRSADFAFLEEGVDARPQEVRMTESLIETMVADFEPSAHRDGYREAVQEVIEAKIEGREIVSAGAPVEEGPPADLMAALRASVEAAKKERRGAAPATGKAAAEPAKKDGAAEEKASRGRRTGRPA
>NC_013595.1|WP_148269369.1|9259835_9260144_+|hypothetical-protein
MAGLALSTAMTGGVVGMGAATTATSAGATAGTSTTSIASFQTNFGWASCGCNRRWRCGGGWGCHRRHNHWSHRRHHQKFNININNNNNNEEDAQNDNNNNNV
>NC_013595.1|WP_012894760.1|9258615_9259530_-|alpha/beta-fold-hydrolase
MSVEPIPSWPGELMDLGERRVHVRSTPPGPSETAVYVHGLAGSATNWTDLMGELSDVVTGHAVDLPGAGHSPEPPGGDYSIAAHARTVTALIDRVAGGPVHLFGNSLGGAVSVRVAATRPDLVRSLTLISPALPDLLPRYGPARVALSAVPRLGEWAATQLSALPAERRLNATLGMCYADLGRIHPERLREAAEELRRRDGLPYAAAALVGSARGLVAEYFRRGAENLWRQAAQVTAPTLVVHGRHDRLVNPRMAARAGRTFPHVRLVLLPDAGHVAQMELPGRVAREARRLICETAPIPIGND
>NC_013595.1|WP_012894759.1|9257356_9258538_-|adenylyltransferase/sulfurtransferase-MoeZ
MSLPPLVEPAAELTVDEVRRYSRHLIIPDVGMAGQKRLKNAKVLCVGAGGLGSPALLYLAAAGVGTLGVIDFDVVDESNLQRQVIHGQSDVGRLKAESAAASVREINPLVDVVVHNVALTTDNVMEIFSGYDLIVDGTDNFATRYMVNDAAVLLGKPYVWGSIYRFDGQASVFWAEHGPCYRCLYPEPPPPGMVPSCAEGGVLGVLCASIGSIQVNEAIKLLTGIGEPLVGRLMIYDALEMNYRSVKVRKDPECVLCGKNPTVTELLEDYEAFCGAVSQEAQEAASGSTITATDLKAMQDADENIYVIDVREPNEYEIVSIPGAVLIPKGEFLNGSALEKLPQDKRIVLHCKSGARSAEVLAIVKNAGFSDAVHVGGGVLSWVKTVDPSLPSY
>NC_013595.1|WP_148269368.1|9256406_9257141_-|hypothetical-protein
MNEVPGQRRPAWSTLVVASTLTLLCAVVAGVAAGTAGTELTRGPSQAELDRAAAGEMALRWQVWPAGRVFPETISYAAEQGGEEKARRVGISPETRCDRGVDAKLRKAMRRAGCRGILRATYLDALQGVVVTVGVAAFTGEAGAAAAKAALPRAGRPSPGLRALAFPGTVTDRFTAAGRQSSLVRQAGPYVVMTTVGQVDGRPAKAVGEQRPAMFAFTGDIADRILAELSTPVRPDCVSEEWRC
>NC_013595.1|WP_012894757.1|9255021_9256413_-|S8-family-serine-peptidase
MLRRAGAAGALAMIALGAAPAAHADDVRGSQRQVLRTLDLPGAWRISKGGDVTVAVLDSGVDPHHRDLVGSVIEGKDFTSGANPPGVAPLRLHGTYMASLIAGHGHGPGGADGVIGVAPRARVLSVRVILEDEEPGFREFNTAERFEDVVARGIRYAVDQGADVINMSISKELATREERAAIRYAISRGVVLVAAAGNEGAGKPDSTGYAPYSYPAAFPGVVSVAAADRGLRRASFSNWNPSVLVAAPGVDIFGAGPGDEYWVGRGTSQATALVSGVAALIKAKYPEMSPALVAQALTAGASRRPTGGYDTGMGFGVVNAPRALAEAARISRHTLTATGPGSHDPARPMGRGVEPVQVIQRDQHKITLYGGVAVAAGFGAVASLMVIAVSVGRARSSAGSAEGAASGLVHGPVDGSATGPADGSVNGITDGSAEPSVNGIAEGSAGGPADAAGHPGPGSPAAP
>NC_013595.1|WP_012894756.1|9253951_9254800_-|hypothetical-protein
MRRAAPTGTGAGARRVRVRAWSAAGRDRLAAERAELATLEQGIRFRTIFLILMGTILAIAASNVLTGAVGLFRETAARPLTAAEQARYIKDDIARRWQAWSTDLVFPAELQYIGLGRAQQYARRVGLAPETPCRSGVDASTGSVLAQYGCRTLLRATYVDQTSTFVITVGIAVLRDEETRIAATAQLPVDDRVGVRPVAFPGTASELFGAAQRQRNAWIPVGPYVVFSTAGYSDGRTRASISPEEILHSELWPAAQAVAGRIARALGDEPNAVPQCTQGNVC
>NC_013595.1|WP_148269832.1|9252725_9253955_-|S8-family-serine-peptidase
MRRRFWAAGALVGLSLTVSTPVGAADVREEQRWVLEAMNVEQAWKTTRGAGVTVALVDSRVDGAVAELRGRVVSGPDMGSAQQARGRPGAAWHGTAMASLIAGAGKGSGGLLGIAPEARILSLPLVLRNGTEDRAGLPEADLRTRADSPLARAIRYAANHGAKVVSMSLGAYGPHKAEREAVSYALSRGVVLVAAAGNDGTSEYALDNATSFWNFPAGYSGVIGVGAVDSTARPAPFSSDNLSVLVSAPGVDVPVVTPGGAYGSSEGTSSATALVAGVAALIKAKYPDISPHLVAQALTSTATSAPADGYDDHVGFGVVDAGAALARAGELVNRAAPATAPAVKHFGEGPLPQEPARPGPEPFRLWLYGAGLLGGLLAFGGAVVMLNRRSEQSVPARGEPVTGQGRPWP
>NC_013595.1|WP_012894754.1|9252222_9252594_-|hypothetical-protein
MGYELRVERPAPLAFAELATVLGQAGFEFRGSQEAGEVLARHGDGVHAIAVWNGGGLSGTPGSDWQVAQLARVSALLGARLVGEDGESYAIRDGLVEQLNGSAAYEFGKIDEILAAGPAVWSR
>NC_013595.1|WP_012894753.1|9251914_9252235_-|MGMT-family-protein
MEPVGHPPPYAERVLDVVERIPRGRVMSYGDIAEYLGEGGPRQVGRVMSTWGGGVPWWRVVHADGTPPPGHEQRCLARWQEERTPLRGARADMRAARWDGLPESTA
>NC_013595.1|WP_148269370.1|9261964_9262594_+|TetR-family-transcriptional-regulator
MTATPDAKPRGTRLPRMARRRQLLSAAQEVFVENGYHAAAMDDIAERAGVSKPVLYQHFPGKQELYLALLDLHVDDMIARCRDALASTTDNKQRVQAAIGAFFDFVSGQGEAFRLVFESDLRNVAPVRQRIERNLRESAEMISHVIQEDTGCSSDEARLLGVGLVGMAEVSARYWISSNGSIPKDAATQLIARLSWRGISGFPRTTAEH
>NC_013595.1|WP_012894765.1|9262682_9262913_+|DUF3107-domain-containing-protein
MEIKIGVRSVHRELVVETNLSAEQVEEELGKALSADRGIFGISDSKGRRVLVPISSLGFIEIGEEEARPVGFGGTL
>NC_013595.1|WP_012894766.1|9263512_9264163_-|hypothetical-protein
MSDSPAGVGDLLGVLAYAELTAFLRLAEDATRHAPSLADRAALGDLAATEYAHFRLLHDRLASLGIDPEEAMAPFVGPLDDWHTQTTPGDWLEALVKAYVGTGIALDFYREAAVHVDAETRRLVEEVLVDEGRSQFAVERVGAALKEDPTQSGRLALWARRMVGEALSQGQHVAAARPELAKLLVEAAGEDITRMFARLTEAHGERMAAMGLTPGP
>NC_013595.1|WP_081453333.1|9264535_9266428_+|DEAD/DEAH-box-helicase
MALPLALNGQDIIGQARTGTGKTYAFGVAMLQRVGKPRKNRKKPRGLVVVPTRELAVQVTEDLVTAAGKLGSRILTVYGGRAYEPQVEALKQGVDVIVGTPGRLLDLVKQKHLDLGQIDVLVLDEADRMLDLGFLPDIERIIKLIPEKRQTMLFSATLPGEIVALSRRYLTRPTHVRAENNDAEAEATPQTTQFVWRAHRMDKIEIVGRLLQCDGRGLTMIFCETKRACDMVVEQLKERGFAAAAVHGDLGQGQREQALRAFRNGKIDVLVATDVAARGIDVDDVTHVVNYDCPQDEKAYVHRIGRTGRAGKTGVAVTFVEWEDLTRWKVINNALSLDFAEPVETYSTSPHVFSDLGIPEGTKGVLPHANRSRAGLAAEEVEDLGETGRVRSRGPRRGREEERDERRERPARTPRERRRTRGGRTGADATEPVENVREETVAEAAPVEEPRRRRSRAGRAAEETPVPVTEQEIQSPVVELTEVEVDVTSRKDDNRDDQPAETAPRRGRTRKAGLNPEVSLTEGTGVQSRREPVAEQADRPRRRREPVAEVPQWEDESVDGHWDDEPVAEAPAPRPQPEKIIPASPFSVIFQSPDLATDDDEIAPSAASERAQSRRRPPSRGQQRGPRRPS
>NC_013595.1|WP_012894768.1|9266548_9267421_+|alpha/beta-hydrolase
MSTPRFLTLPPGVRSRQIDTPVGAFAVLEAMPVSGVPERWPALLVPGLTGSKEDFIAVLQTLAQSGRRVIAVDMRGQFETGGPEDPRAYTCAALGNDIDVLAHTIGGGEPLHLVGHSFGGLVAREAVIDGRTKFASFTLMSSGPAAIVGVRERAGRAMLAELPESGLEHIWHTRMEPEVLAAGVPDEIIAFLRKRLFANSPTGMTTMTGQVLSSPDRCDELTQVEVPTLVLYGEHDDGWPPRMQSEMADRLSAECVVVPGAAHSPAVEAPETTAAALTRFWNAAEARLLG
>NC_013595.1|WP_012894769.1|9267522_9268440_+|DUF2236-domain-containing-protein
MASIEDIVVQPPHTATWLVHIDRSMWVGGVRGLMLQALHPLAMRGVWQNSNFQEDPFGRLRRTADFVGRVTFGSPAEADEIGRRVRGIHRRLRIDDPDTGRTHRVDDPELLLWVHCAEVSSYLSVARRAGLGLTDRQADRYLAEQRRSATYVGLHAEDVPGSTAEMDDYFAGMRSRLKVTPESASTVRFLLWPRLPADLRTLTPGKPAYFPFGALCYYSLPDWARKLYGVLPDVPRSTVSAALKAFRLGMNSVPETVHDRAFMPSTRDMLAGARTRLGAAGYDLGKGLKGLTDPRRWPDGVAAAA
>NC_013595.1|WP_174435309.1|9268464_9269322_-|PD-(D/E)XK-nuclease-family-protein
MPRRLYSCTPSRLNTWLECPRRHRFTYMDRPSPQKGPPWAHNSVGVSVHNALAAWWREPYARRTPVTAAVLVTSGWINEGFRDAEQSAAWRDRAREMTAGYVASLDPSDEPVGVERTVAAKTSVIAVSGRVDRLDRRGDELVVVDYKTGRRPLTADDARSSLALAVYAVASSRVMHRPCHRVELHHLPTGTIAEWEHTDASLARHLSRAEDIAVEASDAEDRYRDWSGTARARGAGRTPPGVPPEIDALFPPKPGPLCSWCDFRRHCPEGQAAAGDRLPWDGLAD
>NC_013595.1|WP_012894771.1|9269352_9270069_-|MBL-fold-metallo-hydrolase
MTARIERVVTEGVVDVDGAEHKVENNTWILGDDEEVIVIDPARDAEKILEKVGEREVLAVVCTHGLPDHVGAAIEVAARDEAVVALHPKDRPLWRLTWPDTWPDIDMEDEGVFGVADVELEVLSTPGVSQGGVSLYCEALGVVFTGKSLQADGPGKVGGEYPALADQLTAIGGRLFTLRHGIRVLPAHGEETTIGALESQFDAWLSGSLTRGDVIEKTEGPLSDGTRAAKINLKLLDE
>NC_013595.1|WP_043653941.1|9270201_9270816_-|MarC-family-protein
MLDVQFFVEAFVTMFVIMDPPGIIPLFLAYTRGRTERERTRIAWQAPIVAFCLIVVFAVFGRAILGYLHVEVAAMQIAGGLLLLLVALQLLTGETGPPPNTMKSNVNVALVPLGTPLLAGPGAIVATIVFAQQAGQKNGGILALALAIAAVHILLWVFMRFSVTILRVIKENGVELVTRVSGLLLSALAVQLIITAIRTLLATG
>NC_013595.1|WP_012894773.1|9270859_9271501_-|hypothetical-protein
MRAAPVCPRCFGPLRPPSAWSSAWRCGPHGDVLPLQPPRRPSSAAVEAISRNALVPAWLPWPLPQGWLVTGLAEAGDERSGVRATVIALSGPSLIHGPADLLIIAEEPGVGLGAGFAGLDGTDPGTGFDEGPPHAKVEIKGHPAALWCVGAAPDRAVYAGEALGNWLWTVIWPAEAGYLMTLAELSLRDLRDQDQAIDPPFGAFSPRLDGEDA

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Crispr_ID: NC_013595_55

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_55

9408365-9408482

Orphan

Consensus_repeat	Method
CGGATGCGGGGACCACTCGGCCGCCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_55

>merge|NC_013595|55|9408365-9408482|CRISPRCasFinder
CGGATGCGGGGACCACTCGGCCTCCAACGGATGCGGGGACCACTCGGCCGCCGGCGGATCCGGGGGCCGCCCCGCGACCTCGGCCTCCGGCGGATGCGGGGACCACCCGGCCGCCGGC

>NC_013595|55|51|9408365-9408482|CRISPRCasFinder
CGGATGCGGGGACCACTCGGCCTCCAAC	GGATGCGGGGACCACTCGGCCGCCGGCGGATCCGGGGGCCGCCCCGCGACCTCGGCCTCCGG
CGGATGCGGGGACCACCCGGCCGCCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012894900.1\|9410370_9411342_-\|TIGR04222-domain-containing-membrane-protein	unknown	unknown	gnl\|CDD\|275063
NC_013595.1\|WP_148269838.1\|9406551_9407517_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894894.1\|9402928_9403504_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_174435311.1\|9411427_9413263_-\|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl\|CDD\|235256
NC_013595.1\|WP_012894904.1\|9414422_9415022_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NC_013595.1\|WP_043658045.1\|9409379_9410192_-\|DUF692-domain-containing-protein	unknown	unknown	gnl\|CDD\|235447
NC_013595.1\|WP_012894892.1\|9400854_9401529_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_013595.1\|WP_148269377.1\|9399823_9400549_-\|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|180276
NC_013595.1\|WP_012894907.1\|9417149_9417578_-\|DUF4307-domain-containing-protein	unknown	unknown	gnl\|CDD\|379491
NC_013595.1\|WP_012894896.1\|9405141_9405909_-\|isoprenyl-transferase	unknown	unknown	gnl\|CDD\|237825
NC_013595.1\|WP_012894890.1\|9397786_9399763_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NC_013595.1\|WP_012894906.1\|9416543_9417044_-\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NC_013595.1\|WP_043653997.1\|9405989_9406511_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377994
NC_013595.1\|WP_012894893.1\|9401525_9402932_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_013595.1\|WP_148269839.1\|9415049_9416303_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_013595.1\|WP_012894895.1\|9403576_9404920_-\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224787
NC_013595.1\|WP_012894902.1\|9413562_9414090_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043654000.1\|9408769_9409387_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894889.1\|9396410_9397802_+\|tannase/feruloyl-esterase-family-alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|284851
NC_013595.1\|WP_012894903.1\|9414182_9414422_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012894900.1\|9410370_9411342_-\|TIGR04222-domain-containing-membrane-protein	gnl\|CDD\|275063	TIGR04222, integral_membrane_protein, TIGR04222 domain. The majority of the proteins with a domain as described by this model have an extreme C-terminal sequence that is consists of extremely low-complexity sequence, rich in Ser or in Gly interspersed with Cys. That C-terminal region resembles ribosomal natural product precursors, although there is no evidence that C-terminal regions of these proteins undergo any modification or have any such function.	2.16528e-34
NC_013595.1\|WP_043653997.1\|9405989_9406511_-\|hypothetical-protein	gnl\|CDD\|377994	pfam08411, Exonuc_X-T_C, Exonuclease C-terminal. This bacterial domain is found at the C-terminus of Exodeoxyribonuclease I/Exonuclease I (pfam00929), which is a single-strand specific DNA nuclease affecting recombination and expression pathways. The exonuclease I protein in E. coli is associated with DNA deoxyribophosphodiesterase (dRPase).	0.00627027
NC_013595.1\|WP_012894904.1\|9414422_9415022_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	4.13107e-31
NC_013595.1\|WP_148269377.1\|9399823_9400549_-\|lytic-transglycosylase-domain-containing-protein	gnl\|CDD\|180276	PRK05820, deoA, thymidine phosphorylase; Reviewed.	0.00419223
NC_013595.1\|WP_012894892.1\|9400854_9401529_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.36494e-81
NC_013595.1\|WP_043658045.1\|9409379_9410192_-\|DUF692-domain-containing-protein	gnl\|CDD\|235447	PRK05409, PRK05409, hypothetical protein; Provisional.	7.15728e-107
NC_013595.1\|WP_012894896.1\|9405141_9405909_-\|isoprenyl-transferase	gnl\|CDD\|237825	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional.	4.04912e-137
NC_013595.1\|WP_012894890.1\|9397786_9399763_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	4.74111e-21
NC_013595.1\|WP_174435311.1\|9411427_9413263_-\|phosphoenolpyruvate-carboxykinase-(GTP)	gnl\|CDD\|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NC_013595.1\|WP_012894893.1\|9401525_9402932_+\|sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.60049e-50
NC_013595.1\|WP_148269839.1\|9415049_9416303_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	1.45981e-32
NC_013595.1\|WP_012894895.1\|9403576_9404920_-\|PhoH-family-protein	gnl\|CDD\|224787	COG1875, COG1875, NYN ribonuclease and ATPase of PhoH family domains [General function prediction only].	0
NC_013595.1\|WP_012894906.1\|9416543_9417044_-\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	6.95204e-58
NC_013595.1\|WP_012894889.1\|9396410_9397802_+\|tannase/feruloyl-esterase-family-alpha/beta-hydrolase	gnl\|CDD\|284851	pfam07519, Tannase, Tannase and feruloyl esterase. This family includes fungal tannase and feruloyl esterase. It also includes several bacterial homologs of unknown function.	6.58562e-08
NC_013595.1\|WP_012894907.1\|9417149_9417578_-\|DUF4307-domain-containing-protein	gnl\|CDD\|379491	pfam14155, DUF4307, Domain of unknown function (DUF4307). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	7.79551e-27

>NC_013595.1|WP_148269838.1|9406551_9407517_-|hypothetical-protein
MKIFDHGTWPLGEADEGVHPAGGERLWSESFYLDFTAEDGSVAGYVRLGLYPNWDRAWYWACLVGRDRPLVLLADDRAPLPGPGLAVRGRDYRATQEVTAPMRSFRLTLEAGAAAVLEDPWRACADPGGDPGGGATTSLEFDLEWETVGGVYPYGFIPRYEIPCRVGGVIRVGGEEIPFFGYGERDHSWGERDWWKVSWLWSSGRLDDGTFFHGMRANVGFEMPWPCFTVSPDGLLDHREGFTAATEFGEDGFPALSRLAVPGSPMTAVPVAFAPVAMTSPDGAVARFPRALCRFEAEDGRRGYGWTEWHQPPGWREHGWR
>NC_013595.1|WP_043653997.1|9405989_9406511_-|hypothetical-protein
MGGLRCLDGSYLTVTPVACRDSVGLPYEVTLELHRDGALYGTVGERCGWLLVRLAKGVAEARAASGAQWPDPDDRFPDEEELFAFRYRARNGVVSGGELRCQLRTIPIWIPAQRGSSGEWRLTRRAFVEAWGGGVGMRAVLTSAELGAFVAALVTEAEECLAPQKSGNSTRTR
>NC_013595.1|WP_012894896.1|9405141_9405909_-|isoprenyl-transferase
MGVRDLVYRLYERRLEAKLSRQKEMAPRHVGVIVDGNRRWARSMGIDDVSRGHRKGADKISELLGWCREAGVEVVTVWLLSSENINRSKDELDLLVKIIEDVVQELVADGWHINPMGALDLLPDHTAHVLKNAKEATSHRPGLIVNVAVGYGGRREIADAVRSLLQEHASKGASIEDLVEVLDVEHIAEHLYTRGQPDPDLVIRTSGEQRLSGFLLWQSAHSEFYFCEAYWPDFRRVDFLRALRSYAARHRRYGN
>NC_013595.1|WP_012894895.1|9403576_9404920_-|PhoH-family-protein
MAPGGERVANPSSSPTSPVTNRRTYVLDTSVLLADPAAMSRFAEHEVVLPIVVITELEGKRHHPELGYFARKALRYLDDLRVTHGRLDEPMPVGEGSIRVELNHSDPSILPVGFRLGDNDTRILTVARTLAAEGRDVVLVSKDLPMRVKAASIGLSAEEYRAELVVESGWTGMAELQVTAEDVETLFEHGTADLAEARDLPTHTGLRLLSSRGSALGRVLPDKSVRLVRGDREVFGLHGRSAEQRIALDLLMDPEVGIVSMGGRAGTGKSALALCAGLEAVLERRQHRKVIVFRPLYAVGGQDLGYLPGSENEKMGPWAQAVYDTLGAVTTPEVIEEVMDRGMLEVLPLTHIRGRSLHDAFVIVDEAQSLERGVLLTVLSRIGANSRVVLTHDVAQRDNLRVGRHDGVVAVVEKLKGHPLFAHVTLTRSERSPIAALVTEMLEDVTI
>NC_013595.1|WP_012894894.1|9402928_9403504_+|hypothetical-protein
MRLRVPATPGTRRLACLLAAALTLCGCGVAPTSIEDRGRPPVISYSPTWVTVYLLRDGRLEPANIPVASDSVKDIISTLFRAGKQPPREGLGSALNKFSHYDTDTTRYSETAQRNDPGGKLGYRLNVIITGEGAISRAGLAQITCTIRQNKQESIWSVEVTRLFPGAPQSLGEHTCFEFRDLAAEGVRLPP
>NC_013595.1|WP_012894893.1|9401525_9402932_+|sensor-histidine-kinase
MRRSYTGLRGRLVITFTLIAVAASALVAGIGYELVKHRVIDLAEQVAVRDVRDTLEGTRVPIGALWPGDSPPTDAQISTLQKSLRMRDGGVVVRYESYLYPDGDFSMNDVPTDLASGAARRMVTKRQVIDGRMWLLIGTPVWRIEPIHIAQPTGMSVFVFVPLTAEEQLLADLRQPLAAAGAIMLVIALAVALVLARRVLLPVRRLGSAARALGAGHLDTRLPVHGHDELAELTATFNETAVALERSVSELRSLEAMSRRFVADVSHELRTPLTAMTAVADMLSEEAERLPKEPATAVRLVLREIGRLRTLVEQLIETSRFDSGTATLHMDTVNVADAVRDCLELRGWSDQVRVNVPQGLAFSVDPLRFDVILANLVGNALRHGEPPVVVAARGTPNGLEVKVRDHGRGIPPADLEHVFNRFYKAGVRGDGSGLGLSIAQANAHLHGGTISAHPQDPGTLFTLWLPSA
>NC_013595.1|WP_012894892.1|9400854_9401529_+|response-regulator-transcription-factor
MAGILLVEDDPSVRTGLELALARQGHSVTSYASGEEALDHIRSRRPEIVILDVMLPGIDGVEVCRRIRKMDQLPVILLTARGDDLDVVVGLEAGADDYVVKPVEPRVLDARIRAVLRRVESVASDRITFGDLVVDRGALKVSLAGREIHLTPTELRLLLELVRHPGQVLNRRYLLRAVWDHTHVADSRLVDACVQRVRAKIESVPAEPDFIHTVRGFGYRFSPP
>NC_013595.1|WP_148269377.1|9399823_9400549_-|lytic-transglycosylase-domain-containing-protein
MSSGPPHLKEHSAPRPRRTAGKPVKAKKQGWLTPMRAVVLGTVAVVLVGGGSFTVYTAIQNASAPPPAPLSLDDLSKMLGDDPFGADPEADILKAQAAQALKENQLAAERGKRKRLDPIVIPTEAPGGGGFDPQQLPPGTANPTGNKALGKQMLDARGWADQWGCLEKLWMKESGWNERAMNRYSGAYGIPQSLPGHKMASAGNDWQTNAATQIEWGLGYIKGRYGTPCGAWGHSQAKGWY
>NC_013595.1|WP_012894890.1|9397786_9399763_-|glycosyltransferase-family-2-protein
MDVKVSVVVPVHNPGDSADACIRSVLEQSMPSEEYEVIFADDGSDDGIQQRLDAVAAVRPNVRVLHLGPDGSPMRARNIGMAIAKGEYVYLMEQTDRLERVALERMYERAVATDADILIGRLVNDQGPPSTVFDGNRERADLFRDRLLSLLTPHKLYRKTFLDAEVLSFADPGGRLAEQAFAIRAYLRAKVVAILADQVCCHVDERPESQVNPYVWGAELRELLDIIDFEVPAGRQRDRMYAHWFRTSVLRRLGGARFLSASARERAAVFTTLRELAVQRFPPRLDPHLPVHLRARAALLRAGRLDQLVVLAEAMRGTHLQADLREVVWDDGVFIMGLAVEIIRGDGSPIRFLPYGEDGLLWEPPVPLDGLRLAPEMADVSQAASRARFEVYVRHEDTGLVYFLPVACSMLRSRHRNGVRLQAAGTARLDVDSAALGHPLPPGLWEIHVRMYGGAHHARTRVTGSPLNCTGVLADYSKRLVIPWWSDRGELGVCVEPRSFAESIVLVSPGTTITRQREHVFVVVPVPYVPPSGGPPAELVLRHAVRREREVCAPALIEPGVPGQHAGRLVAKVPIRLIPRDGALAPGDWVPYLRVDGQETGLRFRVGMGCGGRVEIHESAAGPPAPRYPLLKRVALRMPGARNAARVTRTVQKRYLPS
>NC_013595.1|WP_012894889.1|9396410_9397802_+|tannase/feruloyl-esterase-family-alpha/beta-hydrolase
MRTPSGSRGRAVPAAGLGALTAVITAAALLAGAPAAGAGASTGRTAVDGHCARLDRVTVPGAEHQVKACLDDLTTAGTAVSGHTDPADWAGLHPAGAVNPKDVPGIQVDGYFPDTSTSNTTHGWNHDSQFVLRLPDRWNGGLVVAGTPGNREQYANDFTISDWALAKGYAYAVTDKGNVGVAFHRDGRRPGDAVAEWNQRVTQVAVAAKATIARRYGRPPERTYAAGISNGGYLVRWQLENQAWLYDGGVDWEGTLWRVKGDNLLTFLPPALRAYPKGDTQAMYDAGFARGSEFLWPFHHQYYWDLTQRLYREELDPAFDGDTEAGTPFCTSGTPACDADYDYDARKPYRAVEKIGLTGRIGKPLITVHGTLDTLLPISRSGDVYADMVGDRRPFRYYRITDGTHVDSLYAAYPDRLRPLLPCFRGAFEALEGWVERRQSPPPSATLPRPAGGDLVNDCQLGR
>NC_013595.1|WP_043654000.1|9408769_9409387_-|hypothetical-protein
MPDGHTRQAPAGGGDALDDAGNAVGGDARDGAGDAVGGDAWDGAADAPAGGPGVLNDAGDAVGGRDAQDGVGGAPAGAREALAGAQAVLLAALVAGGEAPPGFDEGRLRIQAASLISKRRGTVARVRPDLVALLGGDFAREFEAYARGRPKPPGGSRADARDFADRLRTVGRLPPEPETAAGAPRWLRPFRRVLKLLAGTVRPTG
>NC_013595.1|WP_043658045.1|9409379_9410192_-|DUF692-domain-containing-protein
MSGSGSLGVGIGWRPEIDLTVERLPGVDFVEVVAENVRPERLPESLRVLRARGMPVIPHGVGLGVGGAEPPDPARLAHLAACARALDAPLVSEHLAFVRAGGMEAGHLLPVPRTRAALSVVAENVRRAQAALPVPLALENVAALFGWPEDEMTEAQFLGELVELTGVGLLVDVANLYTNQVNLGLSATAALDGLPLSELAYVHVAGGHSHQGVWHDTHTAHVPGEVLDILSELCARVDPPGVLLEWDDDYPSDAALEAELGRVRGAMAHA
>NC_013595.1|WP_012894900.1|9410370_9411342_-|TIGR04222-domain-containing-membrane-protein
MEFVLFVTALVLALVVNFAAAALRTEHRRVRSAVTGHHGGQPTPYELAYLSGGPLRVVNTALGVLARGGAVRVSRGGQVSLVLGAPPSPEPIEQAVLDALRARGNSCSVGELRRTTADGQAMSGLRYRLLGMGLLVPDGALTGAARLLSRLLLLSLLAVVFVIGAFLAVPVREFYGAAAVLIGFFTVASGLITYFRQRRALRGLLSKAGHDVLASARKVHVRGARPMAPDLAFAVAVPVALYGLGELGDPGLEEELKQGGTQGGTQGAGCAGGSCGGGSSGSDASYGGGGDFGSGGWGGGDSGGGSSCGGGSSCGGGCGGGGG
>NC_013595.1|WP_174435311.1|9411427_9413263_-|phosphoenolpyruvate-carboxykinase-(GTP)
MADVTAPSPTSHPELAAWVKEIAELTQPDRIEWCDGSEAEWTRLTNLLVEQGTFKRLAKRQNSFYAASDPSDVARVEDRTYICSEREEDAGPTNNWIAPAEMRRTFGEIFKGSMRGRTMYVVPFCMGPLGGDISQLGVEITDSPYVVVSMRVMTRMGDPALRLIEKTAGRADGNPGYVKAVHSVGAPLQHGQADVPWPCNSTKYISHFPETREIWSYGSGYGGNALLGKKCYALRIASTMARDEGWLAEHMLILKLTPPSGETRYVAAAFPSACGKTNLAMLQPTIPGWKVETVGDDIAWMRFGADGRLYAINPEAGFFGVAPGTGESTNANAIKTLWGNSIFTNVALTDDGDVWWEGLTDQPPAHLTDWKGRSWTPDSQEPAAHPNARFAVPAAQCPTIAPEWQDPRGVPISAILFGGRRATAVPLVTESLSWQHGVFTGANIASEKTAAAEGKVGELRRDPFAMLPFCGYNMGDYFAHWIKIGQRENVRLPRIYYVNWFRKNDEGAFIWPGFGENSRVLKWVVDRLNGEAEAVRTPIGLLPAELDTDGLDISDEDLRTLLSVDREVWKDEAALIPAFFETFGDHFPKELWEEYEALVDRLNQDSGTRPN
>NC_013595.1|WP_012894902.1|9413562_9414090_-|hypothetical-protein
MENDEAVKKLRGWFSGRLPEEWFEGPPEIVLDREEIAVVGRLQAPALGDDVSEVERAAAVEGGVQRFREETRERRIEIALEAEHRFRRKVSWGVAVGDETVMFTTLSVPVMTRLRQSERRVLDTLVAAGVARSRSDALAWCVRLVGKNTDTWLTDLRDALQHVDRVRASGPDLSS
>NC_013595.1|WP_012894903.1|9414182_9414422_-|hypothetical-protein
MSILASRATRMNSAARTALAGAGAAHTPSAVPLAWVNARPWPGWTPGGVCGVPDPALTPSSCGTASTTEPAGFVGAPKK
>NC_013595.1|WP_012894904.1|9414422_9415022_+|TetR-family-transcriptional-regulator
MSSPPRAEGLRERKKAKTRRTIQEHALRLFAEQGYEATTVEQIAEAAEISPSTFFRYFPAKEDAVLQDDYAPVLTAMLAAQPADLEPVPALRAAVRGAFERFPREEEPQILARTRLQLSHAALRAKTVDNMIGTIDMLAEGVARRRGLDAPDALSLTTAGAVVGALLPALFGWARSDGARRLADVTDEALALLESGLRP
>NC_013595.1|WP_148269839.1|9415049_9416303_-|C40-family-peptidase
MVLDRRTRVSGLIHEARQDLAYRPRIGYGRRRARLPRQAVPVIVLVLVAALTTGVVVVTQLPEQTRETVALRKPVTRQAVQEQVPAVQPTQAPPPPVAPLTSIHRPNLFVVAGKPLRPAVVAKISQVAGVRAVERADAAEVGMDGKRVQTLGVNPSTFRAYTPKPTARSDRLWRNVSAGEVAVSFVLGSDGGLSLGRSVTTAGQSLRVGAYATMGMGGIDAVVSRQTARALGIPENNALVVSAPKADSAKLRRTLLRILPRGSQVATINPVLAVPRRTTWSAGAFMTAPQVKTALTAAIGKLGRPYVWGAEGPDTFDCSGLVQWAYAQAGIKVPRVTHQQFVSGPQIPLSQAQPGDLLFWRHDPTNPGYVSHVAIYWGNGKMLHAPRTGDVVKIVPVSTRNFAGAVRISPGVAARVR
>NC_013595.1|WP_012894906.1|9416543_9417044_-|transcription-elongation-factor-GreA
MADSHNESVTWLTQEAYDRLKAEFEYLSGPGRVDIAKKIEAAREEGDLKENGGYHAAKDEQGKMEARIFHLRQIIDSARVGEAPRTEGVVGPGMTVTVRFEGDDEEVAFLLASREESGAPIDVYSPKSPLGSAINGKKIGEKATYTMPNGRSNTVEILEAVPYIGN
>NC_013595.1|WP_012894907.1|9417149_9417578_-|DUF4307-domain-containing-protein
MATSEAEEGRQTGPILGTPGDFPDRPERRGRFVVHVVIAILCAVCAGGWGYVMWASKGNTEVIDQVIAFDASRGDSIQITFEVVKPSDREALCRLRAMDVAHVEVGSREVSIPAGEGYVRLTERLETSAQATSGAVHYCYLV

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Crispr_ID: NC_013595_54

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_54

9407625-9407802

Orphan

Consensus_repeat	Method
GGCGGAGGGACATCCGAGGAGCCGGAAGGGCCACAGGCGCCGGAGCGACCCGAAG	PILER-CR

2 spacers

The CRISPR arrays of NC_013595_54

>merge|NC_013595|54|9407625-9407802|PILER-CR
TCGGAGGAGCCGGAGGGGCCACAGGCATCGGAAAGGCCCAGGGTGCCGGAGGGCGGAGGGACATCCGAGGAGCCGGAAGGGCCACAGGCGCCGGAGCGACCCGAAGGGCCCGAGGGACCGGAAGGCGGCGGGACATCCGAGGAGCCGGAAGGGCCACAGGCGCCGGAGCGACCCGAAG

>NC_013595|54|2|9407625-9407802|PILER-CR
TCGGAGGAGCCGGAGGGGCCACAGGCATCGGAAAGGCCCAGGGTGCCGGAGGGCG	GAGGGACATCCGAGGAGCCGGAAGG
GCCACAGGCGCCGGAGCGACCCGAAGGGCCCGAGGGACCGGAAGGCGGCGGGACA	TCCGAGGAGCCGGAAGG
GCCACAGGCGCCGGAGCGACCCGAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012894900.1\|9410370_9411342_-\|TIGR04222-domain-containing-membrane-protein	unknown	unknown	gnl\|CDD\|275063
NC_013595.1\|WP_148269838.1\|9406551_9407517_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894894.1\|9402928_9403504_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_174435311.1\|9411427_9413263_-\|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl\|CDD\|235256
NC_013595.1\|WP_012894904.1\|9414422_9415022_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NC_013595.1\|WP_043658045.1\|9409379_9410192_-\|DUF692-domain-containing-protein	unknown	unknown	gnl\|CDD\|235447
NC_013595.1\|WP_012894892.1\|9400854_9401529_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_013595.1\|WP_148269377.1\|9399823_9400549_-\|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|180276
NC_013595.1\|WP_012894907.1\|9417149_9417578_-\|DUF4307-domain-containing-protein	unknown	unknown	gnl\|CDD\|379491
NC_013595.1\|WP_012894896.1\|9405141_9405909_-\|isoprenyl-transferase	unknown	unknown	gnl\|CDD\|237825
NC_013595.1\|WP_012894890.1\|9397786_9399763_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NC_013595.1\|WP_012894906.1\|9416543_9417044_-\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NC_013595.1\|WP_043653997.1\|9405989_9406511_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377994
NC_013595.1\|WP_012894893.1\|9401525_9402932_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_013595.1\|WP_148269839.1\|9415049_9416303_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_013595.1\|WP_012894895.1\|9403576_9404920_-\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224787
NC_013595.1\|WP_012894902.1\|9413562_9414090_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043654000.1\|9408769_9409387_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894889.1\|9396410_9397802_+\|tannase/feruloyl-esterase-family-alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|284851
NC_013595.1\|WP_012894903.1\|9414182_9414422_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012894900.1\|9410370_9411342_-\|TIGR04222-domain-containing-membrane-protein	gnl\|CDD\|275063	TIGR04222, integral_membrane_protein, TIGR04222 domain. The majority of the proteins with a domain as described by this model have an extreme C-terminal sequence that is consists of extremely low-complexity sequence, rich in Ser or in Gly interspersed with Cys. That C-terminal region resembles ribosomal natural product precursors, although there is no evidence that C-terminal regions of these proteins undergo any modification or have any such function.	2.16528e-34
NC_013595.1\|WP_043653997.1\|9405989_9406511_-\|hypothetical-protein	gnl\|CDD\|377994	pfam08411, Exonuc_X-T_C, Exonuclease C-terminal. This bacterial domain is found at the C-terminus of Exodeoxyribonuclease I/Exonuclease I (pfam00929), which is a single-strand specific DNA nuclease affecting recombination and expression pathways. The exonuclease I protein in E. coli is associated with DNA deoxyribophosphodiesterase (dRPase).	0.00627027
NC_013595.1\|WP_012894904.1\|9414422_9415022_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	4.13107e-31
NC_013595.1\|WP_148269377.1\|9399823_9400549_-\|lytic-transglycosylase-domain-containing-protein	gnl\|CDD\|180276	PRK05820, deoA, thymidine phosphorylase; Reviewed.	0.00419223
NC_013595.1\|WP_012894892.1\|9400854_9401529_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.36494e-81
NC_013595.1\|WP_043658045.1\|9409379_9410192_-\|DUF692-domain-containing-protein	gnl\|CDD\|235447	PRK05409, PRK05409, hypothetical protein; Provisional.	7.15728e-107
NC_013595.1\|WP_012894896.1\|9405141_9405909_-\|isoprenyl-transferase	gnl\|CDD\|237825	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional.	4.04912e-137
NC_013595.1\|WP_012894890.1\|9397786_9399763_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	4.74111e-21
NC_013595.1\|WP_174435311.1\|9411427_9413263_-\|phosphoenolpyruvate-carboxykinase-(GTP)	gnl\|CDD\|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NC_013595.1\|WP_012894893.1\|9401525_9402932_+\|sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.60049e-50
NC_013595.1\|WP_148269839.1\|9415049_9416303_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	1.45981e-32
NC_013595.1\|WP_012894895.1\|9403576_9404920_-\|PhoH-family-protein	gnl\|CDD\|224787	COG1875, COG1875, NYN ribonuclease and ATPase of PhoH family domains [General function prediction only].	0
NC_013595.1\|WP_012894906.1\|9416543_9417044_-\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	6.95204e-58
NC_013595.1\|WP_012894889.1\|9396410_9397802_+\|tannase/feruloyl-esterase-family-alpha/beta-hydrolase	gnl\|CDD\|284851	pfam07519, Tannase, Tannase and feruloyl esterase. This family includes fungal tannase and feruloyl esterase. It also includes several bacterial homologs of unknown function.	6.58562e-08
NC_013595.1\|WP_012894907.1\|9417149_9417578_-\|DUF4307-domain-containing-protein	gnl\|CDD\|379491	pfam14155, DUF4307, Domain of unknown function (DUF4307). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	7.79551e-27

>NC_013595.1|WP_148269838.1|9406551_9407517_-|hypothetical-protein
MKIFDHGTWPLGEADEGVHPAGGERLWSESFYLDFTAEDGSVAGYVRLGLYPNWDRAWYWACLVGRDRPLVLLADDRAPLPGPGLAVRGRDYRATQEVTAPMRSFRLTLEAGAAAVLEDPWRACADPGGDPGGGATTSLEFDLEWETVGGVYPYGFIPRYEIPCRVGGVIRVGGEEIPFFGYGERDHSWGERDWWKVSWLWSSGRLDDGTFFHGMRANVGFEMPWPCFTVSPDGLLDHREGFTAATEFGEDGFPALSRLAVPGSPMTAVPVAFAPVAMTSPDGAVARFPRALCRFEAEDGRRGYGWTEWHQPPGWREHGWR
>NC_013595.1|WP_043653997.1|9405989_9406511_-|hypothetical-protein
MGGLRCLDGSYLTVTPVACRDSVGLPYEVTLELHRDGALYGTVGERCGWLLVRLAKGVAEARAASGAQWPDPDDRFPDEEELFAFRYRARNGVVSGGELRCQLRTIPIWIPAQRGSSGEWRLTRRAFVEAWGGGVGMRAVLTSAELGAFVAALVTEAEECLAPQKSGNSTRTR
>NC_013595.1|WP_012894896.1|9405141_9405909_-|isoprenyl-transferase
MGVRDLVYRLYERRLEAKLSRQKEMAPRHVGVIVDGNRRWARSMGIDDVSRGHRKGADKISELLGWCREAGVEVVTVWLLSSENINRSKDELDLLVKIIEDVVQELVADGWHINPMGALDLLPDHTAHVLKNAKEATSHRPGLIVNVAVGYGGRREIADAVRSLLQEHASKGASIEDLVEVLDVEHIAEHLYTRGQPDPDLVIRTSGEQRLSGFLLWQSAHSEFYFCEAYWPDFRRVDFLRALRSYAARHRRYGN
>NC_013595.1|WP_012894895.1|9403576_9404920_-|PhoH-family-protein
MAPGGERVANPSSSPTSPVTNRRTYVLDTSVLLADPAAMSRFAEHEVVLPIVVITELEGKRHHPELGYFARKALRYLDDLRVTHGRLDEPMPVGEGSIRVELNHSDPSILPVGFRLGDNDTRILTVARTLAAEGRDVVLVSKDLPMRVKAASIGLSAEEYRAELVVESGWTGMAELQVTAEDVETLFEHGTADLAEARDLPTHTGLRLLSSRGSALGRVLPDKSVRLVRGDREVFGLHGRSAEQRIALDLLMDPEVGIVSMGGRAGTGKSALALCAGLEAVLERRQHRKVIVFRPLYAVGGQDLGYLPGSENEKMGPWAQAVYDTLGAVTTPEVIEEVMDRGMLEVLPLTHIRGRSLHDAFVIVDEAQSLERGVLLTVLSRIGANSRVVLTHDVAQRDNLRVGRHDGVVAVVEKLKGHPLFAHVTLTRSERSPIAALVTEMLEDVTI
>NC_013595.1|WP_012894894.1|9402928_9403504_+|hypothetical-protein
MRLRVPATPGTRRLACLLAAALTLCGCGVAPTSIEDRGRPPVISYSPTWVTVYLLRDGRLEPANIPVASDSVKDIISTLFRAGKQPPREGLGSALNKFSHYDTDTTRYSETAQRNDPGGKLGYRLNVIITGEGAISRAGLAQITCTIRQNKQESIWSVEVTRLFPGAPQSLGEHTCFEFRDLAAEGVRLPP
>NC_013595.1|WP_012894893.1|9401525_9402932_+|sensor-histidine-kinase
MRRSYTGLRGRLVITFTLIAVAASALVAGIGYELVKHRVIDLAEQVAVRDVRDTLEGTRVPIGALWPGDSPPTDAQISTLQKSLRMRDGGVVVRYESYLYPDGDFSMNDVPTDLASGAARRMVTKRQVIDGRMWLLIGTPVWRIEPIHIAQPTGMSVFVFVPLTAEEQLLADLRQPLAAAGAIMLVIALAVALVLARRVLLPVRRLGSAARALGAGHLDTRLPVHGHDELAELTATFNETAVALERSVSELRSLEAMSRRFVADVSHELRTPLTAMTAVADMLSEEAERLPKEPATAVRLVLREIGRLRTLVEQLIETSRFDSGTATLHMDTVNVADAVRDCLELRGWSDQVRVNVPQGLAFSVDPLRFDVILANLVGNALRHGEPPVVVAARGTPNGLEVKVRDHGRGIPPADLEHVFNRFYKAGVRGDGSGLGLSIAQANAHLHGGTISAHPQDPGTLFTLWLPSA
>NC_013595.1|WP_012894892.1|9400854_9401529_+|response-regulator-transcription-factor
MAGILLVEDDPSVRTGLELALARQGHSVTSYASGEEALDHIRSRRPEIVILDVMLPGIDGVEVCRRIRKMDQLPVILLTARGDDLDVVVGLEAGADDYVVKPVEPRVLDARIRAVLRRVESVASDRITFGDLVVDRGALKVSLAGREIHLTPTELRLLLELVRHPGQVLNRRYLLRAVWDHTHVADSRLVDACVQRVRAKIESVPAEPDFIHTVRGFGYRFSPP
>NC_013595.1|WP_148269377.1|9399823_9400549_-|lytic-transglycosylase-domain-containing-protein
MSSGPPHLKEHSAPRPRRTAGKPVKAKKQGWLTPMRAVVLGTVAVVLVGGGSFTVYTAIQNASAPPPAPLSLDDLSKMLGDDPFGADPEADILKAQAAQALKENQLAAERGKRKRLDPIVIPTEAPGGGGFDPQQLPPGTANPTGNKALGKQMLDARGWADQWGCLEKLWMKESGWNERAMNRYSGAYGIPQSLPGHKMASAGNDWQTNAATQIEWGLGYIKGRYGTPCGAWGHSQAKGWY
>NC_013595.1|WP_012894890.1|9397786_9399763_-|glycosyltransferase-family-2-protein
MDVKVSVVVPVHNPGDSADACIRSVLEQSMPSEEYEVIFADDGSDDGIQQRLDAVAAVRPNVRVLHLGPDGSPMRARNIGMAIAKGEYVYLMEQTDRLERVALERMYERAVATDADILIGRLVNDQGPPSTVFDGNRERADLFRDRLLSLLTPHKLYRKTFLDAEVLSFADPGGRLAEQAFAIRAYLRAKVVAILADQVCCHVDERPESQVNPYVWGAELRELLDIIDFEVPAGRQRDRMYAHWFRTSVLRRLGGARFLSASARERAAVFTTLRELAVQRFPPRLDPHLPVHLRARAALLRAGRLDQLVVLAEAMRGTHLQADLREVVWDDGVFIMGLAVEIIRGDGSPIRFLPYGEDGLLWEPPVPLDGLRLAPEMADVSQAASRARFEVYVRHEDTGLVYFLPVACSMLRSRHRNGVRLQAAGTARLDVDSAALGHPLPPGLWEIHVRMYGGAHHARTRVTGSPLNCTGVLADYSKRLVIPWWSDRGELGVCVEPRSFAESIVLVSPGTTITRQREHVFVVVPVPYVPPSGGPPAELVLRHAVRREREVCAPALIEPGVPGQHAGRLVAKVPIRLIPRDGALAPGDWVPYLRVDGQETGLRFRVGMGCGGRVEIHESAAGPPAPRYPLLKRVALRMPGARNAARVTRTVQKRYLPS
>NC_013595.1|WP_012894889.1|9396410_9397802_+|tannase/feruloyl-esterase-family-alpha/beta-hydrolase
MRTPSGSRGRAVPAAGLGALTAVITAAALLAGAPAAGAGASTGRTAVDGHCARLDRVTVPGAEHQVKACLDDLTTAGTAVSGHTDPADWAGLHPAGAVNPKDVPGIQVDGYFPDTSTSNTTHGWNHDSQFVLRLPDRWNGGLVVAGTPGNREQYANDFTISDWALAKGYAYAVTDKGNVGVAFHRDGRRPGDAVAEWNQRVTQVAVAAKATIARRYGRPPERTYAAGISNGGYLVRWQLENQAWLYDGGVDWEGTLWRVKGDNLLTFLPPALRAYPKGDTQAMYDAGFARGSEFLWPFHHQYYWDLTQRLYREELDPAFDGDTEAGTPFCTSGTPACDADYDYDARKPYRAVEKIGLTGRIGKPLITVHGTLDTLLPISRSGDVYADMVGDRRPFRYYRITDGTHVDSLYAAYPDRLRPLLPCFRGAFEALEGWVERRQSPPPSATLPRPAGGDLVNDCQLGR
>NC_013595.1|WP_043654000.1|9408769_9409387_-|hypothetical-protein
MPDGHTRQAPAGGGDALDDAGNAVGGDARDGAGDAVGGDAWDGAADAPAGGPGVLNDAGDAVGGRDAQDGVGGAPAGAREALAGAQAVLLAALVAGGEAPPGFDEGRLRIQAASLISKRRGTVARVRPDLVALLGGDFAREFEAYARGRPKPPGGSRADARDFADRLRTVGRLPPEPETAAGAPRWLRPFRRVLKLLAGTVRPTG
>NC_013595.1|WP_043658045.1|9409379_9410192_-|DUF692-domain-containing-protein
MSGSGSLGVGIGWRPEIDLTVERLPGVDFVEVVAENVRPERLPESLRVLRARGMPVIPHGVGLGVGGAEPPDPARLAHLAACARALDAPLVSEHLAFVRAGGMEAGHLLPVPRTRAALSVVAENVRRAQAALPVPLALENVAALFGWPEDEMTEAQFLGELVELTGVGLLVDVANLYTNQVNLGLSATAALDGLPLSELAYVHVAGGHSHQGVWHDTHTAHVPGEVLDILSELCARVDPPGVLLEWDDDYPSDAALEAELGRVRGAMAHA
>NC_013595.1|WP_012894900.1|9410370_9411342_-|TIGR04222-domain-containing-membrane-protein
MEFVLFVTALVLALVVNFAAAALRTEHRRVRSAVTGHHGGQPTPYELAYLSGGPLRVVNTALGVLARGGAVRVSRGGQVSLVLGAPPSPEPIEQAVLDALRARGNSCSVGELRRTTADGQAMSGLRYRLLGMGLLVPDGALTGAARLLSRLLLLSLLAVVFVIGAFLAVPVREFYGAAAVLIGFFTVASGLITYFRQRRALRGLLSKAGHDVLASARKVHVRGARPMAPDLAFAVAVPVALYGLGELGDPGLEEELKQGGTQGGTQGAGCAGGSCGGGSSGSDASYGGGGDFGSGGWGGGDSGGGSSCGGGSSCGGGCGGGGG
>NC_013595.1|WP_174435311.1|9411427_9413263_-|phosphoenolpyruvate-carboxykinase-(GTP)
MADVTAPSPTSHPELAAWVKEIAELTQPDRIEWCDGSEAEWTRLTNLLVEQGTFKRLAKRQNSFYAASDPSDVARVEDRTYICSEREEDAGPTNNWIAPAEMRRTFGEIFKGSMRGRTMYVVPFCMGPLGGDISQLGVEITDSPYVVVSMRVMTRMGDPALRLIEKTAGRADGNPGYVKAVHSVGAPLQHGQADVPWPCNSTKYISHFPETREIWSYGSGYGGNALLGKKCYALRIASTMARDEGWLAEHMLILKLTPPSGETRYVAAAFPSACGKTNLAMLQPTIPGWKVETVGDDIAWMRFGADGRLYAINPEAGFFGVAPGTGESTNANAIKTLWGNSIFTNVALTDDGDVWWEGLTDQPPAHLTDWKGRSWTPDSQEPAAHPNARFAVPAAQCPTIAPEWQDPRGVPISAILFGGRRATAVPLVTESLSWQHGVFTGANIASEKTAAAEGKVGELRRDPFAMLPFCGYNMGDYFAHWIKIGQRENVRLPRIYYVNWFRKNDEGAFIWPGFGENSRVLKWVVDRLNGEAEAVRTPIGLLPAELDTDGLDISDEDLRTLLSVDREVWKDEAALIPAFFETFGDHFPKELWEEYEALVDRLNQDSGTRPN
>NC_013595.1|WP_012894902.1|9413562_9414090_-|hypothetical-protein
MENDEAVKKLRGWFSGRLPEEWFEGPPEIVLDREEIAVVGRLQAPALGDDVSEVERAAAVEGGVQRFREETRERRIEIALEAEHRFRRKVSWGVAVGDETVMFTTLSVPVMTRLRQSERRVLDTLVAAGVARSRSDALAWCVRLVGKNTDTWLTDLRDALQHVDRVRASGPDLSS
>NC_013595.1|WP_012894903.1|9414182_9414422_-|hypothetical-protein
MSILASRATRMNSAARTALAGAGAAHTPSAVPLAWVNARPWPGWTPGGVCGVPDPALTPSSCGTASTTEPAGFVGAPKK
>NC_013595.1|WP_012894904.1|9414422_9415022_+|TetR-family-transcriptional-regulator
MSSPPRAEGLRERKKAKTRRTIQEHALRLFAEQGYEATTVEQIAEAAEISPSTFFRYFPAKEDAVLQDDYAPVLTAMLAAQPADLEPVPALRAAVRGAFERFPREEEPQILARTRLQLSHAALRAKTVDNMIGTIDMLAEGVARRRGLDAPDALSLTTAGAVVGALLPALFGWARSDGARRLADVTDEALALLESGLRP
>NC_013595.1|WP_148269839.1|9415049_9416303_-|C40-family-peptidase
MVLDRRTRVSGLIHEARQDLAYRPRIGYGRRRARLPRQAVPVIVLVLVAALTTGVVVVTQLPEQTRETVALRKPVTRQAVQEQVPAVQPTQAPPPPVAPLTSIHRPNLFVVAGKPLRPAVVAKISQVAGVRAVERADAAEVGMDGKRVQTLGVNPSTFRAYTPKPTARSDRLWRNVSAGEVAVSFVLGSDGGLSLGRSVTTAGQSLRVGAYATMGMGGIDAVVSRQTARALGIPENNALVVSAPKADSAKLRRTLLRILPRGSQVATINPVLAVPRRTTWSAGAFMTAPQVKTALTAAIGKLGRPYVWGAEGPDTFDCSGLVQWAYAQAGIKVPRVTHQQFVSGPQIPLSQAQPGDLLFWRHDPTNPGYVSHVAIYWGNGKMLHAPRTGDVVKIVPVSTRNFAGAVRISPGVAARVR
>NC_013595.1|WP_012894906.1|9416543_9417044_-|transcription-elongation-factor-GreA
MADSHNESVTWLTQEAYDRLKAEFEYLSGPGRVDIAKKIEAAREEGDLKENGGYHAAKDEQGKMEARIFHLRQIIDSARVGEAPRTEGVVGPGMTVTVRFEGDDEEVAFLLASREESGAPIDVYSPKSPLGSAINGKKIGEKATYTMPNGRSNTVEILEAVPYIGN
>NC_013595.1|WP_012894907.1|9417149_9417578_-|DUF4307-domain-containing-protein
MATSEAEEGRQTGPILGTPGDFPDRPERRGRFVVHVVIAILCAVCAGGWGYVMWASKGNTEVIDQVIAFDASRGDSIQITFEVVKPSDREALCRLRAMDVAHVEVGSREVSIPAGEGYVRLTERLETSAQATSGAVHYCYLV

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Crispr_ID: NC_013595_56

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_56

9527312-9527412

Orphan

Consensus_repeat	Method
TGGAGAAGCTCCCGCAGTACGTC	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NC_013595_56

>merge|NC_013595|56|9527312-9527412|CRISPRCasFinder
TGGAGAAGCTCCCGCAGTACGTCCAGGAGCTGCAGAACAATCCGATGATCCGCGACCTGGACCAGCGCTTCCAGATCCTGGAGAAGCTCCAGCAGTACGTC

>NC_013595|56|52|9527312-9527412|CRISPRCasFinder
TGGAGAAGCTCCCGCAGTACGTC	CAGGAGCTGCAGAACAATCCGATGATCCGCGACCTGGACCAGCGCTTCCAGATCC
TGGAGAAGCTCCAGCAGTACGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_169369208.1\|9530123_9530276_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377658
NC_013595.1\|WP_012895008.1\|9534616_9534973_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_013595.1\|WP_012895009.1\|9535000_9535591_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
NC_013595.1\|WP_012894999.1\|9525424_9526639_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_148269847.1\|9521077_9522607_-\|phospholipid-carrier-dependent-glycosyltransferase	unknown	unknown	gnl\|CDD\|224839
NC_013595.1\|WP_012895007.1\|9533600_9534305_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_013595.1\|WP_043654037.1\|9522727_9523582_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223390
NC_013595.1\|WP_148269850.1\|9529143_9529893_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_013595.1\|WP_012895010.1\|9535587_9536214_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|132928
NC_013595.1\|WP_043658088.1\|9532017_9532611_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043658085.1\|9518278_9519481_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022
NC_013595.1\|WP_012895006.1\|9532854_9533457_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012894991.1\|9514049_9515426_+\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|316802
NC_013595.1\|WP_012894989.1\|9511362_9512208_-\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NC_013595.1\|WP_148269848.1\|9523794_9525312_+\|phospholipid-carrier-dependent-glycosyltransferase	unknown	unknown	gnl\|CDD\|224839
NC_013595.1\|WP_012894995.1\|9519600_9521130_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012895001.1\|9528191_9529160_+\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_013595.1\|WP_081453512.1\|9515433_9516390_-\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|238635
NC_013595.1\|WP_012895004.1\|9530272_9531739_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_013595.1\|WP_012894993.1\|9516471_9518253_-\|methionine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237029

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_169369208.1\|9530123_9530276_+\|hypothetical-protein	gnl\|CDD\|377658	pfam06441, EHN, Epoxide hydrolase N-terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.	0.000708506
NC_013595.1\|WP_012895008.1\|9534616_9534973_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.95166e-13
NC_013595.1\|WP_012895009.1\|9535000_9535591_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	2.53185e-88
NC_013595.1\|WP_148269847.1\|9521077_9522607_-\|phospholipid-carrier-dependent-glycosyltransferase	gnl\|CDD\|224839	COG1928, PMT1, Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones].	2.98966e-26
NC_013595.1\|WP_012895007.1\|9533600_9534305_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.41376e-11
NC_013595.1\|WP_043654037.1\|9522727_9523582_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	4.74945e-110
NC_013595.1\|WP_148269850.1\|9529143_9529893_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.05285e-18
NC_013595.1\|WP_012895010.1\|9535587_9536214_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|132928	cd07017, S14_ClpP_2, Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease. Clp protease (caseinolytic protease; ClpP; Peptidase S14) is a highly conserved serine protease present throughout in bacteria and eukaryota, but seems to be absent in archaea, mollicutes and some fungi. Clp proteases are involved in a number of cellular processes such as degradation of misfolded proteins, regulation of short-lived proteins and housekeeping removal of dysfunctional proteins. They are also implicated in the control of cell growth, targeting DNA-binding protein from starved cells. ClpP has also been linked to the tight regulation of virulence genes in the pathogens Listeria monocytogenes and Salmonella typhimurium. This enzyme belong to the family of ATP-dependent proteases; the functional Clp protease is comprised of two components: a proteolytic component and one of several regulatory ATPase components, both of which are required for effective levels of protease activity in the presence of ATP, although the proteolytic subunit alone does possess some catalytic activity. Active site consists of the triad Ser, His and Asp; some members have lost all of these active site residues and are therefore inactive, while others may have one or two large insertions. ClpP seems to prefer hydrophobic or non-polar residues at P1 or P1' positions in its substrate. The protease exists as a tetradecamer made up of two heptameric rings stacked back-to-back such that the catalytic triad of each subunit is located at the interface between three monomers, thus making oligomerization essential for function.	3.24507e-72
NC_013595.1\|WP_043658085.1\|9518278_9519481_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	4.45406e-46
NC_013595.1\|WP_012894991.1\|9514049_9515426_+\|VCBS-repeat-containing-protein	gnl\|CDD\|316802	pfam14312, FG-GAP_2, FG-GAP repeat.	0.00477792
NC_013595.1\|WP_012894989.1\|9511362_9512208_-\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	1.28293e-127
NC_013595.1\|WP_148269848.1\|9523794_9525312_+\|phospholipid-carrier-dependent-glycosyltransferase	gnl\|CDD\|224839	COG1928, PMT1, Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones].	1.76274e-28
NC_013595.1\|WP_012895001.1\|9528191_9529160_+\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	2.17427e-51
NC_013595.1\|WP_081453512.1\|9515433_9516390_-\|TatD-family-hydrolase	gnl\|CDD\|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	3.39148e-98
NC_013595.1\|WP_012895004.1\|9530272_9531739_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.08384e-48
NC_013595.1\|WP_012894993.1\|9516471_9518253_-\|methionine--tRNA-ligase	gnl\|CDD\|237029	PRK12268, PRK12268, methionyl-tRNA synthetase; Reviewed.	0

>NC_013595.1|WP_012894999.1|9525424_9526639_+|hypothetical-protein
MPAPDVAALLSELERSEPDYAEHARSAIDWLTGGEPLETITELNVCEFLWYTLPTKVSGDRPAIARALASLLRLGGLERYAALCLSSATAQILRTYARSGEDAGMAAYQSALDATGVLPPDVPELRWSSIMGPEELGAHGACSAALELAIVSGELAIGSPERQALTRQWLTTPRPELGGDNWLHRVQGERLNRWVLGRGTAWRELAQPFEVRLHAPIPAPAEDHLEALRWLLEQGRRQGGVPLTQRHNLARSVLAESPWSGAELAAVREVAQGQMGALRRAGRRLVITSTGERLLHDRDLLWEAAAAALLAPASGEHGFRASAREVALMLLADGSPADRDRVASVIDCEEWQTSEVDDSLADLGRRLDAFGLRRAGRLTPAGRSAALAALRSHALRPRQYVNMS
>NC_013595.1|WP_148269848.1|9523794_9525312_+|phospholipid-carrier-dependent-glycosyltransferase
MRGDAMWGWLGPLLVAAFGAILRFTNLGRPNAVMFDETYYAKDAWALINFGAERNALKDADKLLMQKSTEIWQQCAPAELDKCASYVVHPPLGKWMIGVGEQVFGMTPFGWRFAGALVGVVSILILARTARRMTRSTMLGCLAGFLLAIEGLHLVLSRTALLDIFLMFFVLAGFACLVVDRDRARGRLVDWYETSPLSEHGPWLGLRPWRIAAGLCLGAACAVKWSGIFFLVAFAVMSLVWDAGARRAVGLRRPYGGMFGKDLPNLLLAMGLIPALTYMVSWSGWFASSSGWGRNWAQATSQGPFFFVFDSVRSWLNYHFQVLGFHTDLATPHSYQSEPWSWPLLLRPVAFFYETPKSGCDASSCSQAVLGVGTPVIWYGGLAALIAMIAWYVATRDWRAGAVLLSYAAGWLPWFYWAIADNRTMFLFYAIPMVPFMILAIVLAAGLIIGPVNAAPRRRIVGASIVGAFTLLSLINFWWLYPVLTAEIIPYAEWHSRMLFKKGWV
>NC_013595.1|WP_043654037.1|9522727_9523582_-|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MGEDGTVTDNGRLVLAGAPIGQVGDASPRLRGALEAADVVAAEDTRRLRRLAGELGAEIRGRVVSYYDANEAGRAAELLQALQDGKTVLIITDAGMPGVSDPGYRLTRLAVEAGITVTSLPGPSAVTTALAVSGLPSDRFCFEGFLPRKPGERARRLDALAGEERTMVFFEAPHRLQAGLAAMAEALGADRPAAVCRELTKTYEEVRRGGLGELAEWAAKGVKGEITVVVAGHVPENLPPVVEDLVAEVARREETGVPRKQAIVDVAKAAGIPKRDLYDAVHRG
>NC_013595.1|WP_148269847.1|9521077_9522607_-|phospholipid-carrier-dependent-glycosyltransferase
MPGNVLWGWLGPLLVAGFGAILRFSGLGRPHAVVFDETFYVKDAFALITYGVERASHGKVEDPVADRMLVAGNTDIWVRCTPPEADPCPLYVAHPPLGKWMIGVGEQVFGMTPFGWRFAGALVGVVSILILARTARRMTRSTMLGCLAGFLLAIEGLHLVLSRTALLDIFLMFFVLAGFACLVVDRDRARGRLVDWYETSPLSEHGPWLGLRPWRIAAGLCLGAACAVKWSGIFFLVAFAVMSLVWDAGARRAVGLRRPYGGMFGKDLPTALTAMAAAPAIAYVASWSGWFASPLGWGRNWAQATSQGPAYFVFDSVRSWLNYHFQVLGYHTDLATPHGYQSEPWSWPLLLRPVAFFWETPKSGCGTDSCAQEVLGVGTPVIWYGGLAALIAMIAWYVATRDWRAGAVLLSYAAGWLPWFYWAIADNRTMYLFYAIPMVPFMILAIVLAAGLVIGKADAAPNRRAVGAAFAGAFMILALINFAWLHPVLVAEIIPHGQWWTRMLFSRWA
>NC_013595.1|WP_012894995.1|9519600_9521130_+|hypothetical-protein
MVTVAERARLETPPGDWSARLWAFLRRHRVFVAALSLAFVLRVVTMLGYGPALWFNDSFEYVSGAVNPDRPSALRPNGYSFWLLLLRPFHSFGLVAFTQHLMGLSIAVLVYALLRRRFGLPGWGATLATVPVLFDAYQIQLEHLIMSDTMFMLLVVGVVTLVLWHRKMSWRLGAVIGLLLALTALTRSIGLPILALVSAYMLIKRTGWKPITAMLTACALPVVAYMGWFASAHGTFSMTSSDGAILYMRTALFADCRKMELDPRKDLEIALLCITDPPSERSFSGQNYLWWARGGQRFHAFGTGSTFTPQMNQAAGTFARRAIMSQPGDYLARVALDFFRAFQWGRPRFPDYATFQQYEFSFEDKVLPAWASYKGNTDTDARKYDPSLPTAEIRGRPSVVGTQVHDPWASFMQAYQRTVRMPGIAVGVLLLIGLAGVAVRWRKLGGPVLLPWLAAFGLILAPAATAEFDYRYLLPAVPLACLAAAISLRRGFARPTARKASASTTARAE
>NC_013595.1|WP_043658085.1|9518278_9519481_-|glycosyltransferase-family-2-protein
MPCLNEAETVETCVRKALACMREHGIDGEVLIADNGSTDGSQQLARDAGARVVHVDAKGYGNALMGGIRAARGRYVIMGDADDSYDFTALLPFVEQLRDGADLVMGNRFKGGIAPGAMPPLHRYLGNPVLSFIGRLFFPSAIGDFHCGLRGFRRDSILKLGLQTGGMEFASEMVVRSTLSGLDVREVPTTLSPDGRSRPPHLRSWRDGWRHLRFLMLYSPRWLFLIPGMVLMTLGLVAGAALTFGPVYIGKLAFDVDTLVGASAAMVIGFQAVLFAVFTKVYAAEEGFLPEDRRVRRLVDIVTLEKGLVVGGLLALAGLGGLVASLVHWQTRSFGTLIPSESLRLVVPSATALIMSFQTIFAALFVSILGIRRTRETPIDVAASAAEEAAEAVSRESTKA
>NC_013595.1|WP_012894993.1|9516471_9518253_-|methionine--tRNA-ligase
MSQHILTAVAWPYANGPRHIGHVSGFGVPSDMFSRYQRMVGNKVLMVSGTDEHGTPIQVQADKEGVSARELADRYNRVIVEDLQALGLSYDLFTRTTTDNHYAVVQEIFKGLYENGYIFPKTTMGAISPSTARTLPDRYIEGTCPICHYDSARGDQCDNCGNQLDPIQLINPVSKINGETPIFVETEHFMLDLPAFAEVLGSWLQSKQGEWRPNVLKFALNLLGDLQPRAMSRDLDWGVPIPLEGWSDQPNKRLYVWFDAVVGYLSASIEWARRSGDPDAWRQWWQSPDARGYYFMGKDNIVFHAEIWPALLLGYNGQGSRDGKPGALGTLNLPSEVVSSEFLTMEGRKFSSSRQVVIYVRDFLARYDADALRYYIAVAGPESQDTDFTWSEFLNRNNGELVAAWGNLVNRSISMAAKNFGVIPEAGELTDADRAMLERSRAAFAKAGAEFEASRFKNATNEAFEVIREANRYLAEQEPWKIKDNPERVKSILHVALQVVDDAKTLLTPVLPGSSNKIYAMLGGTGVWSGMPEIQEVTEEDGRSYPIITGSYEGAARWESTPIRPGTPLAPPTPLFTKLDPKIVEEELARLAG
>NC_013595.1|WP_081453512.1|9515433_9516390_-|TatD-family-hydrolase
MGAPVDPPARPETARARRSRRGPCRLLGRLGAVSTTKLPALPEPLAAEVFDSHCHLDIMVGNRQASSGDPVAQAAQAAQASIEGILREARSVGVTRLVTIGYDLPSSRWNAETAGLHADVYAGVAIHPNEAHASTPETLAEIEELARLPHVRAVGETGLDYYRDWASRDDQHASFRAHIEIAKRTGRALVIHDREAHDDVLRVLADQGAPDVVVFHSFSGDAEMAGRCAEAGYFMSFSGPVTYKNAGYLREAAAVVPKELMLVETDAPYLPPTPHRGKPNAPYLIPLTLRCLAEVKGMEPAGLAEAISANGETVFGAW
>NC_013595.1|WP_012894991.1|9514049_9515426_+|VCBS-repeat-containing-protein
MRLLTSLLVTAMLAVPPAAAGAASARSADCSGASASDFDGDGTDDAVVGDPFADHRGIAGAGAVHVLLGRGEGATVVSAPEPGAGDGFGWSVKLTHLDADRCADLLIGAPYADVSGLRDAGAVYAVYGGAGREAVRLVAPRPEREAHFGWSLASGGTLVAVGAPYEDADGVADAGAVHLFQTGALGQGRRISQDSEGVSGNSEAGDMFGWSVAIGRLGGVSGEQDLAVGAPYENDDGLGRQDGGGRSDSGSIAVLFDVRTAQSGYAGRKWDLHEIVDADAGDRFGYAMAYAEEGDVGYLAVSAPLGDGGRVKDSGLVHLFQASSTAEITPAGVFDQGAEGAAGEGYGFSLAFTGEGGARLAVGVPFDGPDQRGGVRLVPVRDPGQTRLVGRGGPGDRSGWSVGFSGNRLVVGAPDRNGSGAVALLGRNDSTGIPLAPGTGKVPALDGGGPADFGAAVG
>NC_013595.1|WP_012894989.1|9511362_9512208_-|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MSLLGPVEIRNLAEKLDIRPTKKLGQNFVIDGGTVRRIVRVAGLRPDDVVIEVGPGLGSLTLALLPEVRGVVAVEIDPVLAAQLPLTVAERAPEFAERLTVVLADAMRVLPEDLPEDLPTALVANLPYNVSVPVVLHLLETLPSLRTILIMVQSEVADRLAAAPGSKIYGIPSVKAAWYADVRRAGPVGRTVFWPVPNVDSGLVAMTRREPPSTRAAREDVFAVVDAAFAQRRKTLRAALASWAGTPAAAEQALRAAGIDPSERGEQLTVEDFARIAENRA
>NC_013595.1|WP_012895001.1|9528191_9529160_+|YafY-family-transcriptional-regulator
MLETSARLLRLLALLQAHRDWPGTELAGRLGVSPRTIRRDVDRLRTLGYPINAIGGVGGGYRLGAGASLPPLLLDDEEAVAVAVGLRTAADGAITGIAETSVRALAKLDQMLPSRLRYQIDTLSSAVVIIPMPGPTVDPSTLIAIASAVRNHERLRFDYVSHDGSATTRDVEPYRLVQDGRRWYLFAWDTGRSDWRRFRADRLSMRIPTGPRFGPRPLPAEDLADYFAMGPTVNGHRYRAVLTMYGSAAEVTEEVPPTLGVVEPIDDHTCTLRIGSDSLDHLAVWVAAFGFEFDVHEPPELVEHLRTLTARLQRAAWPTAGA
>NC_013595.1|WP_148269850.1|9529143_9529893_-|MarR-family-transcriptional-regulator
MQNGAQSRDFVVLDMLADEDAPSQQDLAHRLGINRTIMVKLLDRLQQAGYVTRTRNPANRRTYILSVTDEGRAALKDMRQAVADRDARLTAPLSPPERRRLNELLSGLVAHDEQSTIPSTEHLVAQAHYRLRRLGDHRLEDYGLRTRHFSLLPALDRLGPCPQQQLAQYLYLTEPATASLIEELVQAGLVVRGQDPHDRRRYALELTDLGRARIPAVRDAMRGVEHDIEEILGPDGTRDLRTLLITLLP
>NC_013595.1|WP_169369208.1|9530123_9530276_+|hypothetical-protein
MIKPFRIDIPQAGPDGLTDRPARTRRPDEVAGPLSEQSHDDVRTFFRDPR
>NC_013595.1|WP_012895004.1|9530272_9531739_+|MFS-transporter
MTDIRSQTGPVGTAAMTPAPAADRRWWALAAVAVGQLMIAADATIMNIALPTVQQELGLTGSQRQWVITIFALGYGGLLLLGGRLSDLIGRKRCLLIGLSGFAVASVLGGMATGPAMILTSRALQGAFGALFTPSVLALIGTTFTTPDERGKAFGIYGTVMGSSSGVGLVLGGLLTDYAGWRWSLFVSVPIAAAAAFGVVATVRATPRHHAGPRVDVTGAILATAGLMALVFGLSQAESDGWTAGSTLTGLAAGLILLALFARSQNRTAHALLPLRVVLHRRRGGAYLAVLCMAVGNFAGFFFLTFYLQNVLDYSPLKAGLAFLPYTAAIVLGVRLARRFVTSAPVRLMLSPGLVATAGGLALLGLLGPDSGYATHLLPVVILLGLGNAWVLVPANSTATLDAGPDAGVAGATVMTSMQIGSSLGIALLGSLAGSAATGYLQAHPGTADLTARATVHGYNLAGLAAAGFLCLAAVAVFLIIGPRKHTP
>NC_013595.1|WP_043658088.1|9532017_9532611_+|hypothetical-protein
MIDHYRDLFECHQWLESGLCWIVVQPLNEEITVDDLLWRLNGGRDPEQRTMAYPTEEAIEEFQPVLFVFEDEGAWGFLEFTYGMAPSDRALTELSKESRVWMTTWHFKGGYTILYAADGKIRARMRDFIFTEHITEDGDPSVLADFRAMLDSLGPQDYRGKYSAAFAFIEAATGMGLESEWLDVEDAPVVILDNPDA
>NC_013595.1|WP_012895006.1|9532854_9533457_+|hypothetical-protein
MRRFLLALTLFLLALTLVIAASGCSGPREPTPAAPAASEQHTDPAPFPLSTAPPTVAGDDSSICAHPNLRTFLNEVEKYAGRAGLDPDAPLRDWESTLEQVRYIAMGTVGSPLGDAAAGLEGYLSAVEGHLDARFSSPEARNYAHVIAKAATRIARTCGVDVDITIPDKPKLSQLGLSRTDPAARAQPVPDPPARETASA
>NC_013595.1|WP_012895007.1|9533600_9534305_+|class-I-SAM-dependent-methyltransferase
MTDFISLPFYDLFHENGHVPEAREKLPPLLAGIRRSILEIGAGTGLITTSLADWTPAEIFALEPSAGMRAMLLSRLNARPELLKRVTVLPCDALSVELDEPVEAIVMINVMYALEPDYRKRLWPVLATRLEPGGLLVFTWRDGGPPAPRPLQELESQQVGRHTYTVLLEILESSEESCEARYLYRITEGDRVISEEEIAGPAYRPVWETIEGELVGAGFVQADAPEGFLAWRLA
>NC_013595.1|WP_012895008.1|9534616_9534973_+|helix-turn-helix-transcriptional-regulator
MASSVPPLRPATDRTDPKSSPAREPLWRHALGERLRGLRHERGEKLSETARRAGVSPQYLSEMERGVKEPSSEMIAAVAGALDVTLVDLTLAVAESLRSAQSSTSRGATCSAAYALAA
>NC_013595.1|WP_012895009.1|9535000_9535591_-|ATP-dependent-Clp-protease-proteolytic-subunit
MSTYTIPNVIAQNPRGERIMDVYSHLLTERIVYLGTAIDAGVANALVAQFIFLESENPDASIQFYINCEGGDPSAMLAIYDTMRYIRPRVETTCVGQAIAVGAVLLAAGAEGKRAALPHARVILHQPAAQGRGTIPDLILQADEVVRVRADIERILSRHTGQTVETLRADTDHDRVFTATAALEYGLLDQIIEERS
>NC_013595.1|WP_012895010.1|9535587_9536214_-|ATP-dependent-Clp-protease-proteolytic-subunit
MGEESKPPLFDTRVRRQLYEGRVLVLDGPLDDDNGTLLATQLIALATQDASTDIALWIHSPGGSVPSMLAIRDIIRLIPCDVSTLAMGIAYSAGQFLLSSGTPGKRRALPHARVLMHQGSAGIGGTAVDIELQADDLRHTRDTVLGLIAEDTGQPVERIFEDSLHDRWYTAQEALDYGFIDAIVQSFDEIAPRDRLRSGFGVTEGVGQ

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Crispr_ID: NC_013595_57

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_57

9738942-9739024

Orphan

Consensus_repeat	Method
CTGCCGGGCACGGACTTCGGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_57

>merge|NC_013595|57|9738942-9739024|CRISPRCasFinder
CTGCCGGGCACGGACTTCGGCGGACCCCATTTCGGCGGTGCCGGCACGTCACACGGCCACCTGCCGGGCACGGACTTCGGCGG

>NC_013595|57|53|9738942-9739024|CRISPRCasFinder
CTGCCGGGCACGGACTTCGGCGG	ACCCCATTTCGGCGGTGCCGGCACGTCACACGGCCAC
CTGCCGGGCACGGACTTCGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012895177.1\|9731319_9732441_+\|esterase-family-protein	unknown	unknown	gnl\|CDD\|223700
NC_013595.1\|WP_081453354.1\|9737056_9738247_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_013595.1\|WP_012895190.1\|9748231_9749956_-\|fatty-acyl-AMP-ligase	unknown	unknown	gnl\|CDD\|341254
NC_013595.1\|WP_012895174.1\|9722188_9723442_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NC_013595.1\|WP_012895176.1\|9724729_9731065_-\|type-I-polyketide-synthase	unknown	unknown	gnl\|CDD\|225858
NC_013595.1\|WP_012895186.1\|9741178_9741529_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|379266
NC_013595.1\|WP_012895175.1\|9723422_9724733_-\|crotonyl-CoA-carboxylase/reductase	unknown	unknown	gnl\|CDD\|188164
NC_013595.1\|WP_012895192.1\|9751598_9752231_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224332
NC_013595.1\|WP_012895188.1\|9742932_9744309_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_013595.1\|WP_012895181.1\|9736777_9736984_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012895179.1\|9733446_9734562_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|334462
NC_013595.1\|WP_012895185.1\|9740856_9741162_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043654115.1\|9739377_9739584_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274681
NC_013595.1\|WP_012895191.1\|9750073_9751282_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|236887
NC_013595.1\|WP_031168267.1\|9721870_9722071_+\|EF-hand-domain-containing-protein	unknown	unknown	gnl\|CDD\|238008
NC_013595.1\|WP_052317156.1\|9732584_9733154_-\|murein-L,D-transpeptidase	unknown	unknown	gnl\|CDD\|341130
NC_013595.1\|WP_012895187.1\|9741718_9742936_-\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340817
NC_013595.1\|WP_012895184.1\|9739788_9740739_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_013595.1\|WP_012895180.1\|9735112_9736462_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012895189.1\|9744305_9748232_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012895177.1\|9731319_9732441_+\|esterase-family-protein	gnl\|CDD\|223700	COG0627, COG0627, Predicted esterase [General function prediction only].	9.9482e-41
NC_013595.1\|WP_081453354.1\|9737056_9738247_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	6.47772e-12
NC_013595.1\|WP_012895190.1\|9748231_9749956_-\|fatty-acyl-AMP-ligase	gnl\|CDD\|341254	cd05931, FAAL, Fatty acyl-AMP ligase (FAAL). FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.	0
NC_013595.1\|WP_012895174.1\|9722188_9723442_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	1.22623e-17
NC_013595.1\|WP_012895176.1\|9724729_9731065_-\|type-I-polyketide-synthase	gnl\|CDD\|225858	COG3321, COG3321, Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	0
NC_013595.1\|WP_012895186.1\|9741178_9741529_+\|DoxX-family-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	9.45515e-09
NC_013595.1\|WP_012895175.1\|9723422_9724733_-\|crotonyl-CoA-carboxylase/reductase	gnl\|CDD\|188164	TIGR01751, crotonyl_CoA_reductase, crotonyl-CoA carboxylase/reductase. The enzyme represented by this model can convert crotonyl-CoA to butyryl-CoA (crotonyl-CoA reductase activity), but more importantly, in the presence of CO2, generates (2S)-ethylmalonyl-CoA. In serine cycle methylotrophic bacteria this enzyme is involved in the process of acetyl-CoA to glyoxylate. In other bacteria the enzyme is used to produce extender units for incorporation into polyketides such as tylosin from Streptomyces fradiae and coronatine from Pseudomonas syringae.	0
NC_013595.1\|WP_012895192.1\|9751598_9752231_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	8.71964e-28
NC_013595.1\|WP_012895188.1\|9742932_9744309_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.74186e-60
NC_013595.1\|WP_012895179.1\|9733446_9734562_-\|FAD-binding-oxidoreductase	gnl\|CDD\|334462	pfam01266, DAO, FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.	5.22732e-22
NC_013595.1\|WP_043654115.1\|9739377_9739584_-\|hypothetical-protein	gnl\|CDD\|274681	TIGR03620, F420_MSMEG_4141, probable F420-dependent oxidoreductase, MSMEG_4141 family. Members of this protein family, related to F420-dependent oxidoreductases within the larger family of a bacterial luciferase (an FMN-dependent enzyme), occurs only within the small subset of species that synthesize F420. Most such proteins are from members of the Actinobacteria, but at least one species, Sphingomonas wittichii, belongs to the Alphaproteobacteria. [Unknown function, Enzymes of unknown specificity].	8.01248e-12
NC_013595.1\|WP_012895191.1\|9750073_9751282_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|236887	PRK11259, solA, N-methyl-L-tryptophan oxidase.	1.59733e-52
NC_013595.1\|WP_031168267.1\|9721870_9722071_+\|EF-hand-domain-containing-protein	gnl\|CDD\|238008	cd00051, EFh, EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.	2.36315e-13
NC_013595.1\|WP_052317156.1\|9732584_9733154_-\|murein-L,D-transpeptidase	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	1.00233e-17
NC_013595.1\|WP_012895187.1\|9741718_9742936_-\|glycosyltransferase-family-1-protein	gnl\|CDD\|340817	cd03784, GT1_Gtf-like, UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.	8.31134e-60
NC_013595.1\|WP_012895184.1\|9739788_9740739_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.90368e-42
NC_013595.1\|WP_012895189.1\|9744305_9748232_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.94414e-114

>NC_013595.1|WP_081453354.1|9737056_9738247_+|tetratricopeptide-repeat-protein
MREGDTADTDSLSGPSQEPEQDVRIVYEQASELRRQGLSQDALTLLEGILRRDPDHAAARYALVVCLTDLGRAAEAVPHLRRVLDAVPEHYEAAYRLGRILQAAADPAGAAAAYRRVLEIAEYSDARTRLRQCEQSPSGATPDGSANPANAFPSGEEVPPPLRARVDDRRAIDRGRLIAGLRLQARYLAPAMLGKALLATVAAIPLVIAYAGGVSGPLLVLLASVFFAVPKVAAALILFAGAAGIVTGFLGSPLRVFDNGRIDLNWPAADSLILAAGTTALLIILILGIPAVLLNSRINGSDVYEYGVEVRRGLIRRTVQFIWYYQIVESPSYLRTLGTYFTHTASLGIRYNDNGASSVTYIEMSGVGTPARVKGIGHYLESRIPAERLPIRGPWT
>NC_013595.1|WP_012895181.1|9736777_9736984_-|hypothetical-protein
MAYRHISPPLTERVVCPLVKRPEPRAVFGDLVRAFLGEVPRRNSWQLSDPIGHPNANRFEHLLARAKR
>NC_013595.1|WP_012895180.1|9735112_9736462_-|hypothetical-protein
MRFTLRRALAVGAMLTVLGVVTPAVAAYSQDDPRSCNDLMGADTPAYVVCHWLAKPEEALGVAMFWLSDDGANLKGASPSDGQFIDCSAPGSSCPALEGEEIGGDENSPYPEGAEDGGAPECEAGQQCSVDGTGEGGDGTPRRSELSGSATPSASPTTTTATQNFTTSAQDVTAAAQTPAGQAVTAAKAAGVRVWLDTELADDWKAGAEGFAAAVKRIGALAARPEVAGIRFTSQLGYNTTFKTDEEVTAFVTAASAALRQAAPGKRLGAHTVVPELACGAEEACKTEMRKRYPLVVPEKVESLLSAGRVDQLSLDTGLLYGGYETWKINAEKAQRNQWIQVRARSWDVLAQVAAEETGLVGQVTPEQVATRASTPVMDGAAQQVNLWTRVQDAQGTVKRLTAWDELKKLNPIKRRLAAVYNPTTPEVDVAADLKKIAENFSQVYLTTA
>NC_013595.1|WP_012895179.1|9733446_9734562_-|FAD-binding-oxidoreductase
MRANSPKVLVVGAGVSGLTTALCLAREGFRVTVVAEKFAPEIVSVVAGALWEWPPAVCGYHHDQISLARSKNWCVTSYRMFDELARAKVPGVAMRRSNFYFGHPVEESPHDLHKMQELAGKVRGFVRDRSLAERNGVSPDYGVVDAYSHMAPMIDTDRYMVWLMRQVKIHGVRVKRYRIEGLLADRRAELLDRFDAEAIVCCAGLGTAQLRGIGMYPLRGALVRVRNGGVRGPRIDEAHCVSHVEGRDEQDIVFIVPRNQRLLVLGGLAEKDEWSTDINLENHGPVREMYERCLAFMPALRNAELDPDEPVRVGLRPFRNENVCLEWDDESQIIYNFAHGGAGFSFSWGCAQEAVGLVRSAVEDRKYSHSF
>NC_013595.1|WP_052317156.1|9732584_9733154_-|murein-L,D-transpeptidase
MEKVQSRLDRLGFKAGPPGSEYGPALRMAVWAFQKANGLPAVDRVDPPTWQALSHPERVRPLVPSGGSVRVEIDLRRQLLTAWKDGKPALISHISTGTGKPYCKNGHCGVAVTPTGDFRAWWRTAGWTTGPLGEQFYTVYFNGGIGFHGSERVPRHPASHGCIRVPLHNARPLFDMIQTGHQVYVRRPA
>NC_013595.1|WP_012895177.1|9731319_9732441_+|esterase-family-protein
MRPARRGLLVLATALLVGLPATAHAAPGSPTGKSPSGPWPAALPGGARVVKERWFGLRMVDITVSSPSVNAMLPVRLLVPRGWSKKAKRTWPVLYMLHGGADNYTAWTRMTDIAAMTENMDAIIVMPEAGRAGNYTDWYNGGKGGAPGWETFHTYELRRLLERGYRAGGRRAVAGLSMGAYGAMKYAARHPGMFRFAGSYSGVMSTRLPGIPELIMNAQAAEREDPKAMWGDPIRNRNVWRANDPAYLAKNLRGMSLYISSGTTSRLGELDPPGAPWSPAHLSEPLSAYTARDLVAKLRFYGVKPVLHLYKDGTHTWPYWTREFKRSFPMILSALGLEASSEEAPPPQEEDEDLWGLLEHRSPITVSGDGASR
>NC_013595.1|WP_012895176.1|9724729_9731065_-|type-I-polyketide-synthase
MDMFGEDEIRRFLTERIATRCRLPLADVDPDRPLEEFGLSSRDAVAVAGELEVLLGRELGPTLVWEYPTVNRLARGLAAGTAAAPAAGRTADPDEPIAVIGVGCRLPGSVHGPEDFWRLLMAGGDAVGQVPEGRWAAFDDGSPRTAEALAATTRHGGFLDDVAGFDADFFGIVPGEAETMDPQQRLLLETAWEALEHSGAAPRSLRGSRTGVFVGISGNEYAHLTTADPAKVDAWTATGAAFSIAANRLSYLLDLRGPSLSVDTACSSSLVATDLAVRSLRSGDSDLALAAGVNLLLSPVITMAFDQGGGTAPDGRCKSFDASADGMVRAEGCGVAVLKRLADAQRDGDRILAVVRATAVNQDGRSNGLVAPNPEAQEELLRTAYAGLEGPGYIEAHGTGTFLGDPIEARAIDAALCGGRTTPLLIGSAKSNLGHLEAAAGITGLIKTVLSLHHGVIPPSIHFRRPNPHIPWDRLKVVTAPTPWPDGLPRAGVSSFGFGGTNAHVVLESAVPAPPSSTAAAGPSTERYGERHGGEAGRDRAGAKVFLLTDVSAERVRDHARVLADWVDSSTAPDTAAPESVALVDVAHTLARRAGRGRAGAAVVARDRGELLAGLRAVQAGGGVTGAAVTGGRGPVWVFSGYGSQWAGMGARLYGEEPVFAAMIDELDPMFGDEAGIGLREIVAGGPAAEGVATVQPVIFAVQVALAELWRSHGVRPAAVVGHSMGEVAAAVVAGGIGLRDAVRVICRRAALLGTLGGGGAMAVLEVAADEVPGDLHVAVHSSPRQCVVTGDPGRVEAFAAEVEARGLLARVLTAEGAGHSPQVKPLLPKLREALAAIAGGKPEIPFYSTVFDDPREVPTFEPAYWAAGVRRPVRLLTALQAAAEDGHTVFTEISPHPVLAAALRDSLPAGTVITHSLRRGHDEELYPQLAATVIAMPSLVTSSSGRLVDLPPSPWRHGRHWFSAPRRTALPPGSHPLLGVHVESPAGHVWTTTVDDLSDAPWRLDPSVWRLHGLPVLPLAAVAALAQAAAAEIRGRAELTDVTLDALLPLPATITTTLTPSGEVEIDAKNAAGVWIRYGTATVASGPSPAEAVPSPAELAERLRDPSGVPVEIGRLGADGIPAGLLTRDIPATAVPVPLAGKLVARVWERTPGVEAPPAGKGSGPRPVRGWLIVAGKGDPRAGRLASGLAAAGHDVHHLDLPGVAAAGPMPSLVPAQRSAPPQAGPVADPPAPPPALPAVDEVVVLVPGGLNPAGAETLFLAVTRIVRDLAGTGARLRLVTHRAQAVLAGEPGDPGAAALRGLVRVLAFEQAGLRACLIDADGPDALLAELAADAPDDEVAWRDGVRHTARLSAVPDDGDRRRAGERTPVVRRGGGYLITGGYGGLGLVVARWLAERGAGRIVLGGRSGPSDEGAETIGELRALGADVQVVTGDLAVPGVARGLVDAVTAGGMPLRGVVHAAGVLDDHLVTDVGPEDLHRVWSAKVHGGLELHEATRDAGLDWWVAFSSAAALLGSPGQAAYAGANAWLDALCDLRRAEGLPGTAINWGTWAEVGGAGQAALPAVSPLTPGEGVEALEALLARGTAAAGVLRLDAAAAVAAFPGIARMPYFADLAGAVASGGEWASAGALASMEPGQALEAVVAKVRERTAVVLGFEVAWLRESTVLTEAGLDSLAATRVRGMIEHDFGVAVPTALLLQGATLGDVALAVAAELGIHGATGGTRPVEPRDAAERQVVVALTRILGREPGVTEEIPADALPVVLDVLGREAGRELSAEGTLTGARVADLLREIDEEEAVRGVVRPLTPAARAYLAARRAAPPTGPPAAPPTGVPPRGAPATGAPVPEGGGQVPLFLGHPAGGTTGVYSLLAGALGADRVVFGLERLDDVGAAGAEAGVSERAARYVAEIRKVQPAGPYRVGGWSFGGILAFEIARQLGAENVELVAMIDSGLPDEVAAAERAEIAARRYADFAAYLARTYGVRVRLAHDELAGLSEAAQLALVETRVAESGVLDLLGEAILRHQITSHEDTRAIEGYRAGTYEGRVVLYRSTDPTPWAVEDIRYAHTDDPTRGFGPFSPELEIVTIAGSHHLNLLDPPHVEVIAAHLGGQL
>NC_013595.1|WP_012895175.1|9723422_9724733_-|crotonyl-CoA-carboxylase/reductase
MTLAQAVVDGADPEELARLEVPTTFRAAHTRKNEVGMFGRRPHGVDDVDKDITKSIHVDDVPMPELAPDEVLVAIMASAINFNTVWTAMFEPIPTFAFLERFGREDPRHDQNFHVLGSDASGVIVRMGAAVRHWKIGDRVVVSPAYVDEQDPITHADSMLGADLRAWGFETNYGGLAEFAVVRATQLLPKPKHLTWEEAACNMLCASTAYRMLVSERGSRMKQGDVVLIWGATGGLGAYAVQLVKNGGGIPVGVVSSEEKAALLRRMGCEHVVDRSQFEHLNDEKAWRRLGAEVRRQVGEDPHIVFEHTGKETFGASVYVARRGGSVVTCGSSSGYAHEYDNRHLWMKLKRIVGSHGANYQECHEVNRLLALGTLQPTLSTVYPLDQTGDAARAVQLNKHVGKVGVLGLAPAEDLGVEDRALRERIGEDRIRLFRS
>NC_013595.1|WP_012895174.1|9722188_9723442_+|helix-turn-helix-domain-containing-protein
MTIKEDSRLVVTGFGDRKRRSHELSDQRLWRSAPAEVARLLRPGLSEVADQVIKEITVRIPEYSRPSDEIYIRAIRLAVDEALRQFVDRIENPSTPWEPDVFRTIGRGEANEGRNLDPLQTAMRLGARVAWRRLTEQSERLGLTPQHLYDLGEAIFVYLDQLADAAAEGFDEARARAAGEIERRRRRLMDLLLSQPAASPDAIADLAKTAGWRLPKTVAGVALDEHSRGYRAPSLPPDVLSGLDRPGPCLIVPDPNGPGQAQTLEAGLRGWKAAVGPAVPLAAAATSLRWAREALDLHRRGVLTEERGVLRCSDHMATLIVFKDEELVSALTEVRLAPLAHLRPSQQDRLAETLLAWLRHGRGAGEVAARLHVHPQTVRYRLRQLEELYGDQLSDPDIRFELEIVLRARQSVSSGTA
>NC_013595.1|WP_031168267.1|9721870_9722071_+|EF-hand-domain-containing-protein
MADDYATTFKIIDVDGDGLISATEMTRLMEVLGQPITPEAAEAAIARIDLDGDGLISLEEFGGYLK
>NC_013595.1|WP_043654115.1|9739377_9739584_-|hypothetical-protein
MLFEFDPGKARAIAREHLYPYLATPYNIAKFRRPGYSEEEIAGGGGDRLVDVFAWCTGLPRCSGRLRW
>NC_013595.1|WP_012895184.1|9739788_9740739_-|LysR-family-transcriptional-regulator
MDVDTRLLRYFAVVAEEGNLTRAAERLFVSQPALTKQIKQLENMLSVRLFTRSRAGMALTEPGRILAEQVPALLEGWGRILRETKNAAGRTERVLRIGYLASAANEATQHIIAEFARLRPDWRAEMRQATWSTPAAGLASGDIDVALVRLPFPGQDDLRVEVLFAEPRWVALPTAHPLATREVISFPDLWDEPFVAAPAATGRWRDFWLATDERDGHPVRIGAVVEQPDDWLSAIANGYGIALAPRSAARFYARPGVTYRPVNGVSSSQVGVAWAPADDADPVIGDFVRCCLSSRSPHVGESDHYEDRQERGRGGA
>NC_013595.1|WP_012895185.1|9740856_9741162_+|hypothetical-protein
MSVFMISYQVADEGVAEVVEAIEKAFAAVDAQRPDGIRYAYLRRAGGTEFVALLELADGVENPLPGLAEARRLQATVARWAVGPAPAPQPFDVLGDYRMRG
>NC_013595.1|WP_012895186.1|9741178_9741529_+|DoxX-family-protein
MFAAYVMVTVVTIVATAGIVLADFTGAGFVLANSAEVGLSPSWIPLLGWLKAAGAVGLLLGLLGVPLVGLAAAAGLVLFFVGAVVAHVRARVFHNIVFPGGYLALAIGSFTLAAVQ
>NC_013595.1|WP_012895187.1|9741718_9742936_-|glycosyltransferase-family-1-protein
MRIAVLAFGSRGDTQPCVALGAGLAARGHRVTVVAAARYGGLVEEAGLGLAPVSVDPLRIVESEEGQAWLRSGPAGFARGFRRIVEPLAERLVTEVDAACAGADLVLSPALGGFGHHLSERYGMPYALLHFQPSEPTGAFPNPLVPLRTLGRAGNRASYALVEGLSWLLLGRMVNRLRSRVFTLGPMRGSPFRQARAGRVPVLCGVSPSVVARPADWPDYVHLTGFWPLERAWAPGPELEAFLGAGPPPVYVGFGSMVPADPDAMAATVVAALRRAGVRGVLQGMPYGGAEDMFAVGDADHGWLFPRVAAVVHHGGAGTTGSGLRAGVPGVVCPFFSDQPFWGARVALLGAGPAPLPVRKVTAETLAGRVARAVRDGRIRTAAARLGERMRAEDGVTRACEALGL
>NC_013595.1|WP_012895188.1|9742932_9744309_-|MFS-transporter
MSDLAARPDGTAARPRPTRRGLLLLVVGLAGFVTTLDNTVVTVALPTLQTELGASLAALEWVVTGYVLTFAGFMLAGGRLADVYGRRRVLVAGLAVFTAASLAAGLATSAGVLVAARLVQGCGAALILPAMLAVVSVGNDDRQRSTGVAVWMASGAGALALGPVVGGYLTQHFHWSWVFLLNVPLGVLVIALAAVAVPESRDASAARVDVPGVATSVVVLSAGTFALTFGAELGWTSPVIVASGAVGVVAAAVFVAVERFGADPMVDLALFRARAFTGGVIAQVLWGLGVNGVFFFTALFLQGVLGFSPTMSGLAFVPLALLVVAVTPLVPYVERRLGAGRTVALGLLLVAGGMAAVGFLRPGDGWADLLPAVCVIGVGSALTMPLGSAVLGAVPESRAGVAGGVFSVAREMSGLFGIAVVGVIVGSSASFTAGYAAGLLTAAALVVVGAAVSLVTLR
>NC_013595.1|WP_012895189.1|9744305_9748232_-|MMPL-family-transporter
MFESFGRTVYRARWSVLALGAVFAVVAGYFGLGLFGRMTDGGFDDPGAESTSAAQWSRQWFGGSSPDVVVLYTHPTFEANDEQFRKDVHAALRDLPAEHVTGTSTYWTTKAAELVSEDRHSTYALITLRGGQLTKQSGYEQVKDRLRTAPAGYTVKVGGPIPLLKDLNTQTGADLQQAEALSMPVLLVLLVLVFGSLVAAGLPLVVGLLSVVGALLLLRLLTEVTDVSVFSLNVVTMLGLGLAIDYSLFVLNAFREEIRRGSPVETAVVRTMATAGRTVAFSGLTVATSLSGLLLFPQMFLRSIGLGAAAVVLVAMAAALIVLPALLAVLGPRVDAIRLAPDFGRHKGGSGTWHAIASSVMRRPVVYLAGVGVVLFALAAPFVHVRFGSVDHRVLPERFESRQVAEEINTGFARNAMSPIDVIVLVERDLVGPMTASAPGALTSEVGTRLGPIGVGNSGITPVTEVGPLDVKAFVERLEALDHVTGVDVTGISQNNGAVRLAVRYDKDPMSDEARALVERIRDLSLERNFQDVVVGGPTAAQLDLQASLESTLPWTALVVCLMTGLLLFAAFGSILLPIKAILMNVLSLGASFGVIVWAFQDGNLADVLGFTPTGSIEATITVLILAVVFGLSMDYELFLLSRVRAEWLRTRDNTAAVAVGLERTGGVITSAALLLLVVIAAFSTAGITIVKMLGVGMFVAIVVDATLVRALLVPATMRLMGDANWWLPGFLRGFHRRIEIREHDVRDHRPAEIAPTYVTVEREDAPGRRRTTPAHRLETSPPVPQLAAPGPPPLAPAVSARVIRSTRDGSDWQWVEETVPDPAPPARSAPPPARPVPPRADPAPPRATPTPPPSRPAPGATPTPPPSRPAPGATPTPPPSRPAPGATPTSPSSRPAPGATPVPPPSHHSPPPSRSAPPRVDPAPRVDPAPSRTVPPSPAPAPAPRPPRPSRPEPRPAPSRASDSRHQQHRSNPYPLPGLDPEQPPPVPAPPAGPSEREPARARKVKKVIKPNLDGPGWHWAEEHEDPSPPQPLLTVEDAVGPARHSPARPPVPGRPVPSPAPPPRARPEPSPPVIRVRLEPDPRPRPEPPPVIRVRPEPASPLRPEPTSPLRPEPASPPRPEQLPPAPRVRPELPAPPSAPRVRPELPPPAPAAATPGPTPGPTPGPTAETGDARRTWSAPPVSSHLIDQLEPLIRHDNRPVPPIAEPPAPRPEPRPEPRPESPPESRSAPCPAPRPEPRPESRPETEDGTRAGASGQVARERRAVQERAGQEGQGAGGWVAVGTRTTRVVRPRQDGSGWEWTEVPE
>NC_013595.1|WP_012895190.1|9748231_9749956_-|fatty-acyl-AMP-ligase
MSDALIARVERWAREIPDAPAYTFLDYSAGHDGVKHTLSWAKADLKARALAVRLREVTLPGDRAAILAPQGLEYVVAMLGTMYARVVAVPLFAPDLPGHADRLIRAYADADPVCVLTTTSALDSVHAFLDGGSAPRPKQVITLDAVSDLLADEWEPEPIGLGDLAYLQYTSGSTRAPAGVEISHANFTANAEQLWEAFRATPRVSTAALWLPLFHDMGLIATIAAPMVGGNQAVFMDPVAFVMHPVRWLRMLSEYDDVFTGGPNFAFEYTAGRVTDEEKATLDLSGVSVMLNGAEPLRGSTIDRFSETFAACGLRPEAHTPGYGLAEATVFVTVMDRDLPARVTLFDRDALTAGRAVPYTGEGRVSDLVSCGVPTGQRVAIVSESGTAKPDGEVGEIWVQGPNVARAYWRDEERSAEVFGNVLDGADGTWLRTGDLGVVHEGELYITGRIKDLIIVDGRNHYPQDVEVTVQEADQAVRRDHVAAFALPGEETERLVVVAERSRRAAGRDLAEVTANIRAAVAKNHDLRLHDFVLTEAGVVPRTSSGKIARRACVLAYLDGAFGPRPAGPRDAGV
>NC_013595.1|WP_012895191.1|9750073_9751282_-|FAD-dependent-oxidoreductase
MKSVIVVGAGIWGTSLALRLAESGWRVTLVEQYQPGHLRQASAGETRLLRASHGTDDWYARMARRARELWRDLGERVGEELYAETGMLWFARRAQGWERASASVLERLDIPHEIWDPARAAALFPDFRGDDLEFVLWEPQAGVVRARRATQVTARLARAAGVTLVRGRAEPYGAGVLEPYDVVVPRGTEAYGMAFQGWAEPSGGPAVRVGDEVLRADRVVWACGAWLPRLFPGMADLQVTKQDTAHFAVAPGWDTPAWVDYDASVYGHGDLDGLGMKVTSDIEGEPYDPETGDRRISPSSEEASRAYLRRRFPSLAQAPVLFSQVCQYTLTLDGEWVIAQPEDGVWLLGGDSGHGFKHAPALAEYVAEILDGAREPEPRFGLHPRVPVRGLRTSGRTDRADR
>NC_013595.1|WP_012895192.1|9751598_9752231_+|helix-turn-helix-domain-containing-protein
MPAESSQTLERGLRLLRLLADGRRGRTPTELAGELGLSRPAVYRLLTTLQSEGFVRRDRDGRVHLGFGVLVLARAVQPLLREGALPTLRGLAEEVGATAHLTVAEGDDGLAVAVVEPSWTDMHVAYREGSRHPLARGAAGLAVLALRQGRTDYVITEGQLQEGARGIAAPVPGVPWLEASVGVVAFTPLDPEVVGPRVAAAAAELATALA

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Crispr_ID: NC_013595_58

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_58

9744941-9745018

Orphan

Consensus_repeat	Method
GCCGTACCCGGATGACGGGGGGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_58

>merge|NC_013595|58|9744941-9745018|CRISPRCasFinder
GCCGTACCCGGATGACGGGGGGAGGCTCGGGGCGCGGACGGGGATCGGGCTCCAGCCGTACCCGGATGACGGGGGGAG

>NC_013595|58|54|9744941-9745018|CRISPRCasFinder
GCCGTACCCGGATGACGGGGGGAG	GCTCGGGGCGCGGACGGGGATCGGGCTCCA
GCCGTACCCGGATGACGGGGGGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012895185.1\|9740856_9741162_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012895186.1\|9741178_9741529_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|379266
NC_013595.1\|WP_012895188.1\|9742932_9744309_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_013595.1\|WP_043654118.1\|9752794_9754090_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012895198.1\|9757350_9759069_+\|HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NC_013595.1\|WP_081453354.1\|9737056_9738247_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_013595.1\|WP_012895196.1\|9754617_9756012_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|170080
NC_013595.1\|WP_012895195.1\|9754376_9754628_+\|ferredoxin	unknown	unknown	gnl\|CDD\|379145
NC_013595.1\|WP_012895192.1\|9751598_9752231_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224332
NC_013595.1\|WP_012895190.1\|9748231_9749956_-\|fatty-acyl-AMP-ligase	unknown	unknown	gnl\|CDD\|341254
NC_013595.1\|WP_012895181.1\|9736777_9736984_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012895183.1\|9738287_9739157_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237057
NC_013595.1\|WP_148269401.1\|9759200_9759548_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043654115.1\|9739377_9739584_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274681
NC_013595.1\|WP_012895191.1\|9750073_9751282_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|236887
NC_013595.1\|WP_043658157.1\|9756051_9757290_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NC_013595.1\|WP_012895187.1\|9741718_9742936_-\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340817
NC_013595.1\|WP_012895184.1\|9739788_9740739_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_013595.1\|WP_012895180.1\|9735112_9736462_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012895193.1\|9752308_9752557_-\|SCO4226-family-nickel-binding-protein	unknown	unknown	gnl\|CDD\|379428

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012895191.1\|9750073_9751282_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|236887	PRK11259, solA, N-methyl-L-tryptophan oxidase.	1.59733e-52
NC_013595.1\|WP_012895186.1\|9741178_9741529_+\|DoxX-family-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	9.45515e-09
NC_013595.1\|WP_012895188.1\|9742932_9744309_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.74186e-60
NC_013595.1\|WP_081453354.1\|9737056_9738247_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	6.47772e-12
NC_013595.1\|WP_012895196.1\|9754617_9756012_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	4.60615e-51
NC_013595.1\|WP_043658157.1\|9756051_9757290_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	4.76737e-91
NC_013595.1\|WP_012895192.1\|9751598_9752231_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	8.71964e-28
NC_013595.1\|WP_012895190.1\|9748231_9749956_-\|fatty-acyl-AMP-ligase	gnl\|CDD\|341254	cd05931, FAAL, Fatty acyl-AMP ligase (FAAL). FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.	0
NC_013595.1\|WP_012895195.1\|9754376_9754628_+\|ferredoxin	gnl\|CDD\|379145	pfam13370, Fer4_13, 4Fe-4S single cluster domain of Ferredoxin I. Fer4_13 is a ferredoxin I from sulfate-reducing bacteria. Chemical sequence analysis suggests that this characteristic [4Fe-4S] cluster sulfur environment is widely distributed among ferredoxins.	1.94002e-10
NC_013595.1\|WP_012895183.1\|9738287_9739157_+\|hypothetical-protein	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	0.00981
NC_013595.1\|WP_043654115.1\|9739377_9739584_-\|hypothetical-protein	gnl\|CDD\|274681	TIGR03620, F420_MSMEG_4141, probable F420-dependent oxidoreductase, MSMEG_4141 family. Members of this protein family, related to F420-dependent oxidoreductases within the larger family of a bacterial luciferase (an FMN-dependent enzyme), occurs only within the small subset of species that synthesize F420. Most such proteins are from members of the Actinobacteria, but at least one species, Sphingomonas wittichii, belongs to the Alphaproteobacteria. [Unknown function, Enzymes of unknown specificity].	8.01248e-12
NC_013595.1\|WP_012895198.1\|9757350_9759069_+\|HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	2.66299e-27
NC_013595.1\|WP_012895187.1\|9741718_9742936_-\|glycosyltransferase-family-1-protein	gnl\|CDD\|340817	cd03784, GT1_Gtf-like, UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.	8.31134e-60
NC_013595.1\|WP_012895184.1\|9739788_9740739_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.90368e-42
NC_013595.1\|WP_012895193.1\|9752308_9752557_-\|SCO4226-family-nickel-binding-protein	gnl\|CDD\|379428	pfam14026, DUF4242, Protein of unknown function (DUF4242). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 90 and 170 amino acids in length. There is a single completely conserved residue C that may be functionally important.	4.14735e-27

>NC_013595.1|WP_012895188.1|9742932_9744309_-|MFS-transporter
MSDLAARPDGTAARPRPTRRGLLLLVVGLAGFVTTLDNTVVTVALPTLQTELGASLAALEWVVTGYVLTFAGFMLAGGRLADVYGRRRVLVAGLAVFTAASLAAGLATSAGVLVAARLVQGCGAALILPAMLAVVSVGNDDRQRSTGVAVWMASGAGALALGPVVGGYLTQHFHWSWVFLLNVPLGVLVIALAAVAVPESRDASAARVDVPGVATSVVVLSAGTFALTFGAELGWTSPVIVASGAVGVVAAAVFVAVERFGADPMVDLALFRARAFTGGVIAQVLWGLGVNGVFFFTALFLQGVLGFSPTMSGLAFVPLALLVVAVTPLVPYVERRLGAGRTVALGLLLVAGGMAAVGFLRPGDGWADLLPAVCVIGVGSALTMPLGSAVLGAVPESRAGVAGGVFSVAREMSGLFGIAVVGVIVGSSASFTAGYAAGLLTAAALVVVGAAVSLVTLR
>NC_013595.1|WP_012895187.1|9741718_9742936_-|glycosyltransferase-family-1-protein
MRIAVLAFGSRGDTQPCVALGAGLAARGHRVTVVAAARYGGLVEEAGLGLAPVSVDPLRIVESEEGQAWLRSGPAGFARGFRRIVEPLAERLVTEVDAACAGADLVLSPALGGFGHHLSERYGMPYALLHFQPSEPTGAFPNPLVPLRTLGRAGNRASYALVEGLSWLLLGRMVNRLRSRVFTLGPMRGSPFRQARAGRVPVLCGVSPSVVARPADWPDYVHLTGFWPLERAWAPGPELEAFLGAGPPPVYVGFGSMVPADPDAMAATVVAALRRAGVRGVLQGMPYGGAEDMFAVGDADHGWLFPRVAAVVHHGGAGTTGSGLRAGVPGVVCPFFSDQPFWGARVALLGAGPAPLPVRKVTAETLAGRVARAVRDGRIRTAAARLGERMRAEDGVTRACEALGL
>NC_013595.1|WP_012895186.1|9741178_9741529_+|DoxX-family-protein
MFAAYVMVTVVTIVATAGIVLADFTGAGFVLANSAEVGLSPSWIPLLGWLKAAGAVGLLLGLLGVPLVGLAAAAGLVLFFVGAVVAHVRARVFHNIVFPGGYLALAIGSFTLAAVQ
>NC_013595.1|WP_012895185.1|9740856_9741162_+|hypothetical-protein
MSVFMISYQVADEGVAEVVEAIEKAFAAVDAQRPDGIRYAYLRRAGGTEFVALLELADGVENPLPGLAEARRLQATVARWAVGPAPAPQPFDVLGDYRMRG
>NC_013595.1|WP_012895184.1|9739788_9740739_-|LysR-family-transcriptional-regulator
MDVDTRLLRYFAVVAEEGNLTRAAERLFVSQPALTKQIKQLENMLSVRLFTRSRAGMALTEPGRILAEQVPALLEGWGRILRETKNAAGRTERVLRIGYLASAANEATQHIIAEFARLRPDWRAEMRQATWSTPAAGLASGDIDVALVRLPFPGQDDLRVEVLFAEPRWVALPTAHPLATREVISFPDLWDEPFVAAPAATGRWRDFWLATDERDGHPVRIGAVVEQPDDWLSAIANGYGIALAPRSAARFYARPGVTYRPVNGVSSSQVGVAWAPADDADPVIGDFVRCCLSSRSPHVGESDHYEDRQERGRGGA
>NC_013595.1|WP_043654115.1|9739377_9739584_-|hypothetical-protein
MLFEFDPGKARAIAREHLYPYLATPYNIAKFRRPGYSEEEIAGGGGDRLVDVFAWCTGLPRCSGRLRW
>NC_013595.1|WP_012895183.1|9738287_9739157_+|hypothetical-protein
MASGPDKHPETELQPADHPGKMPLGQEQAPPTASETATLHQSAGHHSSPFTAAEYPAANDFHKAAGEQPKAPHTATEIGTPHGPEHPSGPVPPHTQATQVSVDAATPTQPVSVDAGTHREWQAINPHHAQPGLDGGAPADAATRPGIAQSPLDEVNDQYRIVPDPPQATGFPDPPKADQPGSSTTLPHKPTLSTEHREDLQPGDTDGAGASNGASTGLLPGTDFGGPHFGGAGTSHGHLPGTDFGGQNSSDLPETALALGLDHAGAGTSFDMDHGFTHHADMGPPPTIV
>NC_013595.1|WP_081453354.1|9737056_9738247_+|tetratricopeptide-repeat-protein
MREGDTADTDSLSGPSQEPEQDVRIVYEQASELRRQGLSQDALTLLEGILRRDPDHAAARYALVVCLTDLGRAAEAVPHLRRVLDAVPEHYEAAYRLGRILQAAADPAGAAAAYRRVLEIAEYSDARTRLRQCEQSPSGATPDGSANPANAFPSGEEVPPPLRARVDDRRAIDRGRLIAGLRLQARYLAPAMLGKALLATVAAIPLVIAYAGGVSGPLLVLLASVFFAVPKVAAALILFAGAAGIVTGFLGSPLRVFDNGRIDLNWPAADSLILAAGTTALLIILILGIPAVLLNSRINGSDVYEYGVEVRRGLIRRTVQFIWYYQIVESPSYLRTLGTYFTHTASLGIRYNDNGASSVTYIEMSGVGTPARVKGIGHYLESRIPAERLPIRGPWT
>NC_013595.1|WP_012895181.1|9736777_9736984_-|hypothetical-protein
MAYRHISPPLTERVVCPLVKRPEPRAVFGDLVRAFLGEVPRRNSWQLSDPIGHPNANRFEHLLARAKR
>NC_013595.1|WP_012895180.1|9735112_9736462_-|hypothetical-protein
MRFTLRRALAVGAMLTVLGVVTPAVAAYSQDDPRSCNDLMGADTPAYVVCHWLAKPEEALGVAMFWLSDDGANLKGASPSDGQFIDCSAPGSSCPALEGEEIGGDENSPYPEGAEDGGAPECEAGQQCSVDGTGEGGDGTPRRSELSGSATPSASPTTTTATQNFTTSAQDVTAAAQTPAGQAVTAAKAAGVRVWLDTELADDWKAGAEGFAAAVKRIGALAARPEVAGIRFTSQLGYNTTFKTDEEVTAFVTAASAALRQAAPGKRLGAHTVVPELACGAEEACKTEMRKRYPLVVPEKVESLLSAGRVDQLSLDTGLLYGGYETWKINAEKAQRNQWIQVRARSWDVLAQVAAEETGLVGQVTPEQVATRASTPVMDGAAQQVNLWTRVQDAQGTVKRLTAWDELKKLNPIKRRLAAVYNPTTPEVDVAADLKKIAENFSQVYLTTA
>NC_013595.1|WP_012895190.1|9748231_9749956_-|fatty-acyl-AMP-ligase
MSDALIARVERWAREIPDAPAYTFLDYSAGHDGVKHTLSWAKADLKARALAVRLREVTLPGDRAAILAPQGLEYVVAMLGTMYARVVAVPLFAPDLPGHADRLIRAYADADPVCVLTTTSALDSVHAFLDGGSAPRPKQVITLDAVSDLLADEWEPEPIGLGDLAYLQYTSGSTRAPAGVEISHANFTANAEQLWEAFRATPRVSTAALWLPLFHDMGLIATIAAPMVGGNQAVFMDPVAFVMHPVRWLRMLSEYDDVFTGGPNFAFEYTAGRVTDEEKATLDLSGVSVMLNGAEPLRGSTIDRFSETFAACGLRPEAHTPGYGLAEATVFVTVMDRDLPARVTLFDRDALTAGRAVPYTGEGRVSDLVSCGVPTGQRVAIVSESGTAKPDGEVGEIWVQGPNVARAYWRDEERSAEVFGNVLDGADGTWLRTGDLGVVHEGELYITGRIKDLIIVDGRNHYPQDVEVTVQEADQAVRRDHVAAFALPGEETERLVVVAERSRRAAGRDLAEVTANIRAAVAKNHDLRLHDFVLTEAGVVPRTSSGKIARRACVLAYLDGAFGPRPAGPRDAGV
>NC_013595.1|WP_012895191.1|9750073_9751282_-|FAD-dependent-oxidoreductase
MKSVIVVGAGIWGTSLALRLAESGWRVTLVEQYQPGHLRQASAGETRLLRASHGTDDWYARMARRARELWRDLGERVGEELYAETGMLWFARRAQGWERASASVLERLDIPHEIWDPARAAALFPDFRGDDLEFVLWEPQAGVVRARRATQVTARLARAAGVTLVRGRAEPYGAGVLEPYDVVVPRGTEAYGMAFQGWAEPSGGPAVRVGDEVLRADRVVWACGAWLPRLFPGMADLQVTKQDTAHFAVAPGWDTPAWVDYDASVYGHGDLDGLGMKVTSDIEGEPYDPETGDRRISPSSEEASRAYLRRRFPSLAQAPVLFSQVCQYTLTLDGEWVIAQPEDGVWLLGGDSGHGFKHAPALAEYVAEILDGAREPEPRFGLHPRVPVRGLRTSGRTDRADR
>NC_013595.1|WP_012895192.1|9751598_9752231_+|helix-turn-helix-domain-containing-protein
MPAESSQTLERGLRLLRLLADGRRGRTPTELAGELGLSRPAVYRLLTTLQSEGFVRRDRDGRVHLGFGVLVLARAVQPLLREGALPTLRGLAEEVGATAHLTVAEGDDGLAVAVVEPSWTDMHVAYREGSRHPLARGAAGLAVLALRQGRTDYVITEGQLQEGARGIAAPVPGVPWLEASVGVVAFTPLDPEVVGPRVAAAAAELATALA
>NC_013595.1|WP_012895193.1|9752308_9752557_-|SCO4226-family-nickel-binding-protein
MTKFMDVHHGMAGITDQQFRDAHDADLAIQAEEGVSFEHAWADPAEGVIYCLSEAPDAEAVQRVHERAGHPADEIHPVPLTV
>NC_013595.1|WP_043654118.1|9752794_9754090_-|hypothetical-protein
MTAGDGFAYDGSVFNEVAMSLEGMAERLGTLRYSGDTVALPTWALGGAGEWPARHEYGKTWEELEQEFNYGETEGTSLAEMMRRTRKSYAGAEGASVRRVLDAVTEARNADPGEVSFSSGYSDYEMESFAESLMNPTALSYGAGVAAMAAGMGGRAIHNFTKREESAFLLDRRREINDTAEKRIGRVGKSIVSHMEDTNWTNDLGEKDAAYRNSLYKRVDGLHAERERRLSELAKYSKATQANLARAKAFSWAAMAGGLVWTAMIIPSDEDLDRAVAGWGELAYYCGEAFGHDTGLVREAITAAWAGPAMDAADARLVEFVAAGVHLAERVRRLSDALSDTVEDLDRIHKVALVFSVASLGAIAGAGIAARFNPALRPFVELLGARLSAVTIVCANIAPAAAAAAIAGYRAFDASRATKIGDREITGFRRS
>NC_013595.1|WP_012895195.1|9754376_9754628_+|ferredoxin
MRLVVDLNRCQGYAQCAFLAPDVFTMHGEEALMYDPGADEARREQVMRAAAACPVQAILVDQVDAPGTPERPIALERAGTDGR
>NC_013595.1|WP_012895196.1|9754617_9756012_+|FAD-dependent-oxidoreductase
MAVDGSDKAFRRHGRVVVVGASLAGLRAAETLREEGFTGSLTMIGDEPHEPYDRPPLSKQVLLGKVPADGTALPRRRAIDAEWRLGVAAAGLDLTGKRVRLADGQEVGFDRLLIATGTRARPWPRDAEADLDGVFVLRTSDDAARLNRRLAARPRRVLVVGAGFTGSEVASACRERGLEVTVAERGPAPLVGALGGVVGAVAAELQREHGVDLRCCITVTALEGDPAGRLRRAHLSDGGTLDVDVAVIALGAMRNTEWLAGSGLGAGPRGVACDAGCRAFDVHGIVTDDIFVAGDVARSPHPLFGYQFLSLEHWGNAVAQAEVAAHNMISRGPDRRPHLWVPAFWSAQFGVNIKSVGVPPMGDEIIVTQGSLAEHRFAAAYGHQGRVIAAVTFDHARWIDFYREQIESAAPFPPDFTNVDRRPEGLRPVGADFPDPALPTHGPTVTLSGYSPSDRRVVFTPARA
>NC_013595.1|WP_043658157.1|9756051_9757290_+|cytochrome-P450
MPSGTLLHQITDYASRADPYPLYAELRRTPVSRQDDGVYAVSTYWEIVSLLRDPRLSSDARNRAAQPGEVLPPEEDTTLPPSFLRLDPPEHDRLRRLATRPFGPPHCPRRVHDMGGELARMVSGLVDGFQGRDRVDIVEDFAYPFPVMVICKLLGVPHQDEALFHGWAETIVAALDPNPAEGPAERQRVAQQARSELGAYLAGLISEHRRAPGDDMLSALVTDHGPDGLMSPVEVITTAVLLLIAGHETTVNLITNGMLTLLRHPEALKRLRADPDLAVPLVEELLRYEPPVQLLPQRTALADIDIAGTVIPAGAPIWLVLASGNRDPRRFRDPDRFDPLRRDNEHLGFGNGIHYCFGAPLARLEAQLALTELARRLEDPRLVEDPPPYRQNPVLRGPRHLPVAFGGLAAQR
>NC_013595.1|WP_012895198.1|9757350_9759069_+|HAD-IIB-family-hydrolase
MRYHAVACDYDGTLAADGHVDDGTVAALERLVRSGRRLLLVTGRQIDELRRDFGRLDLFDRIVAENGAVLYRPREPAEQATSPLAEGPPAALVERLRDLGVEPLGVGSVIVATWEPNGETVLHAIRDLGLEMQVIFNKGAIMVLPSGMNKASGLAAALAELGISEHSTVGVGDAENDHAFLAACECAVAVANALPAVKERCDLVTGRDHGAGVTELVDRLLADDLAGVDVVRHRLPLGTGAAGQVSVPPYGLRLLVAGPSHSGKSTVTAALLERVAGAGYQFCLIDPEGDYADGVEGAVVLGDARRAPTGEEVLRLLEDVRQSVVVNLLGLSIDDRPGFFEALLPRLSALCARQGHPHWLVVDEAHHMMPEGFGLQPAGLLGEMGGLLLVTVHPGAVSEPVVRALNAVVAVGERPGDILGTFAAATGQDMSHRDFPDLPTGELLFWELGGEPVRVELIPPEEERRRHRRKYATGELGEDKSFYFRGPREALNLRADNLTAFCRLAEGVDDDTWTYHLGRGDYSRWLAEQVKDEELAAEVAGVERAPGESAAETRRRVCELIEARYTAPAEPT
>NC_013595.1|WP_148269401.1|9759200_9759548_+|hypothetical-protein
MTGRAVRGCTVGRELQVDQVSLSGAGQRMREPVDLFGQHTDALLKAVAGGERSPWGIGVIGMVMDQINETLAQACGHLHANLDMTGTGVREMGDQARATESLNMATVQDLDPSIR

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Crispr_ID: NC_013595_59

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_59

10050201-10050271

Orphan

Consensus_repeat	Method
CACGGCCGGGAGCGTCGCCGGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_013595_59

>merge|NC_013595|59|10050201-10050271|CRISPRCasFinder
CGCGCCCGTGAGCGCCGCCGGGAGCGCGCCCGTGCTCACGGCCGGGAGCGTCGCCGGGAGCACGGCCGGGA

>NC_013595|59|55|10050201-10050271|CRISPRCasFinder
CGCGCCCGTGAGCGCCGCCGGGA	GCGCGCCCGTGCTCACGGCCGGGAG
CGTCGCCGGGAGCACGGCCGGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_012895461.1\|10058120_10058543_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100004
NC_013595.1\|WP_012895448.1\|10045029_10045371_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012895460.1\|10057608_10058124_-\|3-hydroxyanthranilate-3,4-dioxygenase	unknown	unknown	gnl\|CDD\|183930
NC_013595.1\|WP_012895456.1\|10052697_10054482_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|293789
NC_013595.1\|WP_012895457.1\|10054603_10055827_-\|kynureninase	unknown	unknown	gnl\|CDD\|226363
NC_013595.1\|WP_148269872.1\|10050406_10051459_+\|DUF2293-domain-containing-protein	unknown	unknown	gnl\|CDD\|370799
NC_013595.1\|WP_148269870.1\|10046400_10047246_-\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787
NC_013595.1\|WP_012895446.1\|10034884_10035409_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012895462.1\|10058539_10059307_-\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|226480
NC_013595.1\|WP_081453520.1\|10033348_10034713_+\|hydrolase	unknown	unknown	gnl\|CDD\|185683
NC_013595.1\|WP_043654211.1\|10051738_10052536_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043658257.1\|10059303_10060278_-\|4-hydroxy-2-oxovalerate-aldolase	unknown	unknown	gnl\|CDD\|181282
NC_013595.1\|WP_148269871.1\|10047477_10048263_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NC_013595.1\|WP_012895459.1\|10056633_10057605_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185
NC_013595.1\|WP_148269869.1\|10045377_10045749_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NC_013595.1\|WP_148269868.1\|10032028_10033225_+\|family-20-glycosylhydrolase	unknown	unknown	gnl\|CDD\|119333
NC_013595.1\|WP_012895450.1\|10046011_10046404_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_043654204.1\|10035497_10044914_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_013595.1\|WP_012895443.1\|10031030_10031876_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_013595.1\|WP_012895458.1\|10055864_10056629_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213186

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012895461.1\|10058120_10058543_-\|RidA-family-protein	gnl\|CDD\|100004	cd00448, YjgF_YER057c_UK114_family, YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	5.21696e-35
NC_013595.1\|WP_012895460.1\|10057608_10058124_-\|3-hydroxyanthranilate-3,4-dioxygenase	gnl\|CDD\|183930	PRK13264, PRK13264, 3-hydroxyanthranilate 3,4-dioxygenase; Provisional.	2.06766e-107
NC_013595.1\|WP_148269869.1\|10045377_10045749_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	8.78298e-13
NC_013595.1\|WP_012895457.1\|10054603_10055827_-\|kynureninase	gnl\|CDD\|226363	COG3844, COG3844, Kynureninase [Amino acid transport and metabolism].	4.40398e-168
NC_013595.1\|WP_148269872.1\|10050406_10051459_+\|DUF2293-domain-containing-protein	gnl\|CDD\|370799	pfam10056, DUF2293, Uncharacterized conserved protein (DUF2293). This domain, found in various hypothetical bacterial proteins, has no known function.	1.96527e-26
NC_013595.1\|WP_148269870.1\|10046400_10047246_-\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	3.05939e-06
NC_013595.1\|WP_081453520.1\|10033348_10034713_+\|hydrolase	gnl\|CDD\|185683	cd00413, Glyco_hydrolase_16, glycosyl hydrolase family 16. The O-Glycosyl hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A glycosyl hydrolase classification system based on sequence similarity has led to the definition of more than 95 different families inlcuding glycosyl hydrolase family 16. Family 16 includes lichenase, xyloglucan endotransglycosylase (XET), beta-agarase, kappa-carrageenase, endo-beta-1,3-glucanase, endo-beta-1,3-1,4-glucanase, and endo-beta-galactosidase, all of which have a conserved jelly roll fold with a deep active site channel harboring the catalytic residues.	1.00714e-23
NC_013595.1\|WP_043658257.1\|10059303_10060278_-\|4-hydroxy-2-oxovalerate-aldolase	gnl\|CDD\|181282	PRK08195, PRK08195, 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated.	0
NC_013595.1\|WP_148269871.1\|10047477_10048263_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.8155e-15
NC_013595.1\|WP_012895459.1\|10056633_10057605_-\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	1.00891e-24
NC_013595.1\|WP_012895456.1\|10052697_10054482_-\|hypothetical-protein	gnl\|CDD\|293789	sd00042, LVIVD, LVIVD repeat. LVIVD repeats are mainly found in bacterial and archaeal cell surface proteins, many of them hypothetical. Structurally, LVIVD repeats have been predicted to form a beta-propeller, with each repeat forming one four-stranded anti-parallel beta-sheet blade.	3.81865e-08
NC_013595.1\|WP_148269868.1\|10032028_10033225_+\|family-20-glycosylhydrolase	gnl\|CDD\|119333	cd06563, GH20_chitobiase-like, The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.	1.79105e-161
NC_013595.1\|WP_012895462.1\|10058539_10059307_-\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|226480	COG3971, COG3971, 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism].	9.51155e-56
NC_013595.1\|WP_043654204.1\|10035497_10044914_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.60582e-16
NC_013595.1\|WP_012895443.1\|10031030_10031876_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.28351e-74
NC_013595.1\|WP_012895458.1\|10055864_10056629_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	1.61084e-61

>NC_013595.1|WP_148269871.1|10047477_10048263_-|methyltransferase-domain-containing-protein
MTSEYVFDNDGAHSADQHRYLAELLDPLTSERLGQTGVTDGWNCLEIGAGGGSVALWLAERVAPTGRVLATDIKPGLIPARPGLTVVRHDIVDDPLPPDEFDLIHARLVLSHLPERQRVLERLRAALRPGGWLQVDEIDISNWSPLLTPDRGARELYETYIAAMARVLGAAGSDPTWGASAAQAMSEAGLVDVDPECRIEVWGPGSAGIGLLTSNSLHLEERFLEAGMTRTQLGDVRAVMADPGFRAVSFTVHSVLARRSL
>NC_013595.1|WP_148269870.1|10046400_10047246_-|SseB-family-protein
MLRHAEFALPITPAAAEGHEPAVWPVEADDERTWLLVYTSIEAMRTGTGGAVRHCRVVTLPELAAAWPDLRWGLAVNPGLPVHFFLESGAVARLAVPSLAQDREAEPESGVAIVQKLLRPRDVHAYLADGGSRVSGYCHHALDVAHIATPTVLVDALGQSADEMVTEEGSVVILRWYAVGPDLYRTPYGGLDEETMAAVGGWVIEEPPFIGMGLVPNVDQLIREYKVDGVELPYGAEICELTIEGVERRHAMYNGDLGRWMPIQDAPAGAPDRGRGSEGHP
>NC_013595.1|WP_012895450.1|10046011_10046404_-|hypothetical-protein
MTRRHSYRARWRGAEYPSALDQHPDRLWIRLRSPEPAEGFEEQAPGCYVRPVPAEDCQAVYSVTTVGEWRGAACQICDERDGELLVEYIGGLVPVALGLGMERVERGVYRRWVPGHEVDGVRENVVLLAL
>NC_013595.1|WP_148269869.1|10045377_10045749_-|YbaB/EbfC-family-nucleoid-associated-protein
MRAYADELRTTFKRLQDEAPALHEEARAVQVTEKSPDGLISATVGARGDLVRLDIDPRIYRKPDARQLADSIAETIHRAAAKAQERVIELFEPLVPGDQMKAHLEGDLQGVLEQMANQLLGKR
>NC_013595.1|WP_012895448.1|10045029_10045371_-|hypothetical-protein
MPNDFDRVDIDIDPAVAAELSQWDRVASDLHAMWKEKIAKIQQLNNPSTWGADTPGLAFQASYYQGGSLFQMIINGGQIIADVVAEPARIRKAVANSLTTDHDQGLMMNNLQA
>NC_013595.1|WP_043654204.1|10035497_10044914_-|hypothetical-protein
MSGSTSSSTSSSNTSVVSGGYLAEDPGDGFATDVTPAWGESLPAWADTLIALLSAGQMWPDGSESTQWRLRTLWHELAQGLDAHVEEGVPVIDRTLQKWDAPPTDNSVANLESLYSPDSGVPVLKENASAYAAKLGNFALETQYSKLSINVAFWISLIAISIGLVAVFFTGGLAARLIVLIAKKTRWDIDTILRRLAAAAGRSAGARAVLPAAQRVAAASNASTRTILSSAGRKALVVETVEESTEEGVIEGKAQGDQIKLGTRDRYDSRRIIDATIGGAVGGIVGMKAAPGVSRMFGRGMASRGFPGRTLQGITQAGVVNIIASAAGGVVVGLGHGRLTLPTGESSIGAFAGAAGRYGSLSPFNGAVIQAVRTPVTTFQSGLAASFASYDATTAANTTNLATATTPPPDPASSESSPSGASPAGTPPTGGGPTVAGGARSTNGQAAPGGQAAPAKSAPAAATQGAPAGSTSAGQTASGPSAQGGQTGANPSGPGTAAQGSQGGPAQGGQSSQTGSAQGGQAASAQGGQTGSNPSGPGTAAQGSQGGPAQGAQGSQAGSAQGNQTGSAPVGQGTPGQSAPAAPDPSASGAQGSQSGAAQGSQAAPAGQSAPGPSAQTASAAPDPSGAGTATQESQTGASGQSAPGPSAQTAPVQSGGPVPVTATQGAATTQSAPATQTNTATQSAPATQGGQSTASSPTTTELAQSAMAEVMDILTPDAQLMAGGSLRLPRPDGSTVHLPAAPLRLVRERLETRAADGAGPHRLRAEAAAWLGIEIARAADRPRLEGAIQALHWLAEASPETGDAALRVATEIVMDNPTGVDRSELTARAGRFADTLVAAANEPVSTPVDEHGALRPGRQVETAEEIARKVEEIRAELAGKASKPAGSSSLSRPSRLTELSKQVRELTASLSDAETGLKEREKAKNDGARAAEKSARDTVKKVKKAEEAERKGEKLPGERDRRAPERRRQARAEALLSREEAARDRRIAHRYGEAADQAKAAREAFKSASDAMRRLAAESRPGPAAALAAEVAGLVREANSRLAEYQEALKKALPPKAGQAAGFPAGDLPYLTALTERINKTLAREKIAYRFTAAELEGKLRAEFHQLVSGDGAVLRVGDGRDAEIRVKLRLSDLVEVLAPEVLASELMLGRMRQGNQAVSVSIGANTGTAAGVDVPGLIGSLIKMLPEHNALRTSLETVLPYVSLEGGVSHGSGESNSGKATSYVTGGGVTDNRGTSTKFSADALLEVEIRTPKKKGEQGEQGWRSAGRVTEGSPGDATHAEVWISHAHIEHGPEKTVQLRFDQGKTPPLPEAVQVISMTGLEEANTKLLAELGPELAAMGSMAQHEIRTMVVEELPNNLPKLVNNPDGIRRTITADGGAVVEIQAKAELRWIPAANGQVELDASAMGTPSTKQLGEKLGVSFSEVSGGRGDNRSWNANAGAGVKFGGKAFNPEIGPFDMADHKGLSAKAGANGSYGRSRSGGMNVGGTSIVPIVGRESGHNQAGTFKVVTTFTVTVHGESKPRAPITETLDVTAQMPETDAYNAGFPVDEAMIQRDIDGSPTFRDDLVPEPPPGRKDEPASWQGEGPHQVRTIGMGHAEVLTDLADMRRKTKEYLRGIGMSDPDVMADVDEQLSELRLGTDFNQLVKDGILVRVTDKRSGRRPQQAVLRVRVPREWGNIGYVGHGTAKTVVTLYIGSDTGSSSSGMSTSGSGGVAAGAEFKSGDGESKFSGDGGYGRNGGRSSGDNEGLTTNNVLLAEGRTTTAESKETARILIDHLKGDETVRVASEDVRVVHRMPAGMLAAAGSTGPSATFQTPGKLLDRARPWAVDLGVGTDVLNELAKKMGIPRDSEAYYAIAQFLSDSSLLSHTQFLQTPYDIEFVVESAGARPRRWSVSISGEVGDSRHITTGEMVDGDINLTLGSHGTSSGKRSGGGLNGSVGGGVSQAENPTTGGGAGGSRSTSRSTSTGRLPISGLETLGIDVGDQALFAAGLTTTVTVTEVGTGKTETVTAADGTYMYLKPERDVLHMYARGEMPLPLDEVADAVERFLYGHLTLRRETQALLVERYLRDMKAARLSGAELGLAAEHTPKVLFDRLMVLFGNHNPDIPKEGGLGRRLAVLLASERRRAATPDLVELAESVRKKLGQSLPTEIILRYGKDGPETDLHRAILDAIEVYAPGLLRTNPVLRRGLFSGFAGRNWLGGKLSNMLSRAGFVYSPTVRADLGNGTIPPVRVQMDFGDGPVELIAHHTDQGIIIQRYIYNQLTVSESSGTTYGGNLGVNGSVGSADINVGTSGSGDVSYSHSGSASRTKQLTELQRIFNFGVDEVRHALNATITVGDENGARPPVVVKLEGQMTRLVASDLVQPEQSQRVPDPRPVKLPKFFMVDGVEVDGLPEAVQAVLADDRLLGKEGAREVLETLERDLSQMRQAASFRQMLTPEGSMTIRFTDPRKPGKVVELTLRVRPQDMHVTVTGRKNTEIGWVNRIQHISERVVIWSRKLSIGKVSRFFGLSRSKSKGWSISVQSSVSGGNRTEISVFQKGTAASVEVPVVFDVTAEVTTVKRGRVETGLRIEARDAATGQADITMFERDLRQTEAGRGAEGRRRWGWNLGDPAVTRTTGTTERPGWRARWRSGPPAATAPSLDLDTLTTQATDAATAEGKAGVGITPDVLHRKIVETARESLAGRWTPGTPIPITATASAPGQMGPVTQARLLARGLRTDVLIELREPDGTVHRYRATPKGKLYSEVPDGGFASAFATLHPDLVTLADQAGVNLRVLHNGSPEEGDFAGRVREALTATAPAAPSTAPAAAPSAPSTAPAAVPQSPAGPAAPQQPSTARPSGSTFQPGATGSVPARAASAPRQGVIRRFLLAPLTGTSSEYVSARYNEYRHLAERWQKADTAIRSLEQQLSAPGQGRTALEEQLDALAKRRDALAQQLNEVAEDLRERGQVPPVPPWEAGPQTGPGGALASLLNRSDGETLPPSHWESQFWDRMRRLSNTTGLPEEEAEEPCLCPPGEPCVCGRRPQVPGPRSGTPSPSPSPTPSPASPSPSPSPSGDSPSAKPSQPEKAENSLSADGHTVTTGPDSTLWEIAEEAYGDGRYWKDIWERNREKIGSDPGALPVDLELVVPDRPKSR
>NC_013595.1|WP_012895446.1|10034884_10035409_-|hypothetical-protein
MPFPVTRSGDEAHLYLDLHPCSCGSAGTAWESAPGSVDGEPVARYSGTCPDCDAEREFLFGLPEREVPAVRFPTFGGPEPSQLLDAGEWMWVADLTAGNVPADEPREAEQALTIATAAVEEVIKFIPPGEDEVPERAFWSDRGRRVRGAEPSRFVLDRLLVVRNTYRDAAAAIR
>NC_013595.1|WP_081453520.1|10033348_10034713_+|hydrolase
MLLTLIGVAAGPASAQQSLRLQYRTSAAGGTADQVEPWFDLVNDGASAVPLSGVRIRYYFKADPGASQYRFACSWAVVSCSTVTGTFGTIAPGTATADRYLEVGFTSGNLAAGARTGDLQLRFHRSDWQRITQSDDHSFGPARTTYGDWTRVTVHRNGALVWGTAPTGGDPSPSPTPTVTPTNPGGGGVVFDDFTYGTSDDPALTAHHWTVRTNSGGPGVPGATWPKENVTFPTVSGANKALQLRADTDGTGAGTRQSEVLHQRKFLEGTYAARVKFSDAPVSGPDGDHIVQTFFTITPLAFDMDPDYSEQDFEYLPNGGWGEPGNIMYATSWETYRNEPWEAVNVHNEVRQSYAGWHDLVLQVSGGRIRYYIDGALFAEHGGVYYPETAQSVNFNLWFISGGLVGSSAQRGYVQQVDWFYHSKNEVVAPAEVLNRVTGYRFASTAWVDTVPSP
>NC_013595.1|WP_148269868.1|10032028_10033225_+|family-20-glycosylhydrolase
MAPDDPSLGEEGYRLDVTPGGVELTAGGPAGRFYGSKTLSQLGPLVPYGTIEDRPRFAWRGVMLDVARHFMPKAFVLRLIDLLAEHKLNVLHLHLTDDQGWRLEIKRHPRLTEVGARRGGFYTHDDIREIVAYAADRFVTVVPEIEMPGHAQAAVAAYPLLGNDPSRDLQVWSEWGISEHVLNLEESTIRFCQDVLDEVVGLFPGRYVHVGGDECPVTEWERSPGARRRLAELGLRPRDACAWFIGRMASHLESHSRELVCWDEPDREPTPGTTVMVWRDEQADRGDNDVILAPHTRTYFDYRPSADPGHPPAQERVLTLADTYAFAPDPAARGVQCQLWTEYMPTPEQVEYMAFPRMCAFAEVAWGSPGDYPDFLLRLDAHLARLSARGVRVGPLVP
>NC_013595.1|WP_012895443.1|10031030_10031876_+|carbohydrate-ABC-transporter-permease
MTAPTPGRRLRRVPLNLAALTVLAVSVFPVYWMVLTAFKPTRDIQARTPGFWPAHPTLEHFATAVSADGFWTFWRNSLTVTVGAVLLALAVALLAAFAVARMRWRGRRGFILMVFIAQMAPWEALLVSMFIIARDTGMLDRLSMLTLVYFMTTLPFTIVTLRGFLAAIPAELEEAAQMDGCGRTAAFRRVVLPLLAPGLMSTSLFGFITAWNEFAFANALIIKNQDDRTLPVWLSSFSNVFGTDWGATMAASTLFMLPVLLVFLVLQRRVTSGMIAGAVKG
>NC_013595.1|WP_148269872.1|10050406_10051459_+|DUF2293-domain-containing-protein
MVEAAEAALAQRKYVTAIDVLTGIRWLHTRHVDTWRQGRVAALEELSAVDGAKMADAVAALRRWALAKGLTPSETAYVSGGRDRGELRFVAGGDDSAFRVHWISPDMSEARRRQLAERQSKAPDLVVVEQQAWQCAGCGDTGPYLIMESAGPHCLTCADMDHLVFLPSGDAALSRRAKKESGLAAVVVRLNPRRKRYERRGILVEEAALALAEEQCLADEEVRLRRRERDRERRAGEDVEFQAGMAMEITRMFPGCPPERAEEIARHAGQRGSGRVGRTAAAKVFDTNAITLAVVASVRHLDTDYDRLLMAGVPRAEARDRIRTAIDRVLDRWRAAAGAPVRDRPRGETA
>NC_013595.1|WP_043654211.1|10051738_10052536_+|hypothetical-protein
MNATAAHTRPNRRRPSKGAMALTLAGSLSIALTATVSASAVTSPSQGSLAAATTRPSTPSPPPVPFNHSIRDEADRKCSPRNFFRFHDFEPRNFFIPRTHFIDGPGGSMTATVRRQHRVYFEVEIEREKGSEINRDRARSRSRSTTTTPAPDAAGTTTADTNATDAVDTKNLIRRLRNNVNPLLAEELIIEAGHEYTQEISDGMYGNMWYRVFGYRIGFSQWRQLTDCSTHRVVTGIASVPARVEGWRYWETRHPMYKGRRLSDK
>NC_013595.1|WP_012895456.1|10052697_10054482_-|hypothetical-protein
MRHFLRHALITSGVAGLVLASGTAVRAAAPDDPNIPSVCGDRRPADPQAGTYGMQLDGTFRHPSLTPAGEERFSFPGGAQDLFGKTKGYDPKSYLEGPIKLEAAYRGAEFTPDYFHSWQNIVDFDGRRYLFQYDRSEGRVYDVTDVKKVKIVESLSRNDIKAEYGENVELKDGKDWKAHDYWGASTIQWNARLDAYVMVQSFEQKRQVGELGDSVEHSKFRNAEGVRKLRETTSFKGFKVYQLNGPRKKDWKLLATVTTDGSADNPLNAPVDGPQQGSGSLDVPYWTGGKYMFVAAAPLDTWSNTEVPTYLYSAGYQAYDMSDPAKPKKIGEWHRKGQLAGESADYAKNPRCGNQTSWMGARMPLFIPKPVEEGGKYGFAALGGYGLSVLDISNPAKMNEVAHLDLPMSVGGTEADNVDVSQFEKTGMIYVSGYPLGEDCHEPYKDIFQIDVRNPAKPRIVGALPRPEPAAAAPFGDYCQRGGSFGPKRSGYYTSPGEPKQGLLPYAFYNAGVQFFDTRDPKHPKIVAQFVPAGFAKGVPDYALGNQTHGTYVEWDRKIAWVFTNDGIYAISSKKLLGTPNLGKPAKPFRTSAR
>NC_013595.1|WP_012895457.1|10054603_10055827_-|kynureninase
MTISRADCVALDADDPLKHLRDEFVLPDGTIYLVGNSLGAMPRAAAAATARVVEEEWGRQLVGGWNSAGWFDLPLTTGDRLAPLIGAGPGQVVVGESTSIAIVKAVSAAMGLRPGRRVIISDLANFPTDRYMVEGLVKALGGYEVRDIGVLDEVLGDDVACVLMSEVDYRTGERHDTAAVTAKVQAAGALMIWDLCHSAGAFQVDMSAADFAVGCTYKYLNAGPGAPAFVYVNPRHHARAEHMLTGWHGHAAPFAFEPGYRPAEGIRRFTVSTPHVLSYAPLNASLDIWERVDLGQVRAKSVALTSLFIDLAEELRAPYGVELVTPRDPERRGSQVSLRHPDGYPVMRALIDRGVHGDFRAPDILRFGFAPLYIRFADVYDAVATLTEVLEKEHWRDERYQRRLAVT
>NC_013595.1|WP_012895458.1|10055864_10056629_-|ATP-binding-cassette-domain-containing-protein
MLSLHRVTMCFGTVKAVDGMDLAIRRGERRGLVGPPGSGKSTVMRLIAGVIRPTGGRVEYDGHDVTDLSESRRPGIARIFQHGTAVAGLTCVEHVAMALGAHGRGGLPVPSPPDRRHALTVEVLDLLRAAGLAGEAGEATDRLPPGARRRLEIAVALASRPRLLLLDEPMAGMTAEERVRFADLLRGLPAGLTVVLTGCDRDAVAAVSSHVTTLERPEQITVPAWRVRRRPARHVERKFHVPEPPDALTFADAG
>NC_013595.1|WP_012895459.1|10056633_10057605_-|amidohydrolase
MIIDVHTHYVPKGWPDLGWPGAPRLRVESEREAMILLGDREFRRIQDDCWNLPARLEQMDADGVDVQVVSPTPVFFSYERPAAQAAGVARVFNDLALEICASERLVPFCQVPLQDPDLACAELDRCLAAGHAGVEIGNHVGDRDLDDEGIVQFLQHCASVGAPVFVHPWDMPGGPRLQRWMAQWLVGMPAETHLSVLALILGGVFDRVPDSLRICFAHGGGSFAFWLGRFENAWRRRNDLVGVSEFPPSAYLERFSVDSVVFDERALRLLVDTMGEDRVMLGSDFPYPLGESPAGSLIRGARFLTDDARAKLLGGNAARFLGR
>NC_013595.1|WP_012895460.1|10057608_10058124_-|3-hydroxyanthranilate-3,4-dioxygenase
MIPPIDFNKWIDEHAHLLKPPVGNKIIFEDSSDLIVMVVGGPNARTDFHVDPYEELFYQVRGNMHINVMTPEGPDTVHVREGQMWLLPPNMPHSPQRPEEGSVGFLVERIRPEGVLEKFRWYCQECSAVVHQVELQVRDIVADLPPIFQSFYDDEKARTCDDCGALHPGKG
>NC_013595.1|WP_012895461.1|10058120_10058543_-|RidA-family-protein
MTDGIVIRGKATPRGRFPHVKRAGDFIYVSGTSSRRPDNTIAGAAADEFGTVTLDIAEQTRAVIENIGDILKAAGADLSDLVQITAYLVNMNDFGGYNAVYAEYFDEAGPTRTTVAVHQLPHPHLLIEIQAVAHRPEERQ
>NC_013595.1|WP_012895462.1|10058539_10059307_-|fumarylacetoacetate-hydrolase-family-protein
MTDIHKLAAVLDEAARTARAVPQPEQGYDVAAAYRVQEELLRLRLARGDRLSGVKLGFTSEGKRRQMGVHDVIFGRVPESSAILDGSYADISGYIHPRVEPEVVYLIGRRIATVADALAPGAIAAVAPGIEVIDSRYENFRFSLPDVIADNTSAAGYVVGPWQPYDSARWNLGVVFEIDGRPVQTGSTGAILGDPRRAVAEAARLAGAHGVVMEPGWILLAGAATPAEPLAPGAHVRAEIRHLGSVSFTADGGQS
>NC_013595.1|WP_043658257.1|10059303_10060278_-|4-hydroxy-2-oxovalerate-aldolase
MHAIRHRYTTAQAAEIAAALDAAGVAAIEIAHGDGLAGGSFNYGAGAHTDDEWIEAVAGAVRRARLTTLLLPGIGTIHDLRRAHALGVTSVRVATHCTEADISAQHIATARELGMDVAGFLMMSHMAPADELARQAKLMESYGAQCVYVTDSGGRLTMDGVRERVRAYRSVLDEGTEIGIHAHHNLGLGVANSVVAVENGTYRVDASLAGMGAGAGNCPIEVFVAVADLMGWEHGCDLHALMDAADDLIRPLQDRPVRVDRETLTLGYAGVYSSFLRHAEAASARYGVDTRTILTEAGRRRMVGGQEDMIVDIALDLARAGGTP

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Crispr_ID: NC_013595_60

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_013595_60

10094996-10095189

Orphan

Consensus_repeat	Method
CCGTAGGCCTGCTGCTGGCCGTA	CRT

3 spacers

The CRISPR arrays of NC_013595_60

>merge|NC_013595|60|10094996-10095189|CRT
CCGTAGGCCTGCTGCTGGCCGTACGCCTGCTGCTGGCCGTACGCCTGCTGCTGACCGTAGGCCTGCTGCTGGCCGTAGCCCGGCTGGGAGGGCTGGCCGTAGGGGGACTGCTCCTGGGAGGGCTGCTGGCCGTAGGCCGGCTGCTGCCCGTAGGCGCCGGTCCCCTGCTGACCGTAACCCTGCTGCTGGCCGTA

>NC_013595|60|3|10094996-10095189|CRT
CCGTAGGCCTGCTGCTGGCCGTA	CGCCTGCTGCTGGCCGTACGCCTGCTGCTGA
CCGTAGGCCTGCTGCTGGCCGTA	GCCCGGCTGGGAGGGCTGGCCGTAGGGGGACTGC
TCCTGGGAGGGCTGCTGGCCGTA	GGCCGGCTGCTGCCCGTAGGCGCCGGTCCCCTGCTGA
CCGTAACCCTGCTGCTGGCCGTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_013595.1\|WP_148269415.1\|10093759_10094107_-\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_012895495.1\|10088687_10089638_-\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NC_013595.1\|WP_012895490.1\|10083810_10084131_+\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NC_013595.1\|WP_012895489.1\|10083439_10083814_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133388
NC_013595.1\|WP_012895503.1\|10101493_10102276_-\|type-III-pantothenate-kinase	unknown	unknown	gnl\|CDD\|237347
NC_013595.1\|WP_012895500.1\|10097239_10098205_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_013595.1\|WP_012895502.1\|10099966_10101469_-\|bifunctional-lysylphosphatidylglycerol-synthetase/lysine--tRNA-ligase-LysX	unknown	unknown	gnl\|CDD\|234778
NC_013595.1\|WP_012895492.1\|10085876_10086962_+\|DNA-integrity-scanning-protein-DisA	unknown	unknown	gnl\|CDD\|237395
NC_013595.1\|WP_012895496.1\|10089995_10092503_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|214361
NC_013595.1\|WP_169369513.1\|10098829_10099504_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_013595.1\|WP_081453368.1\|10096002_10096659_-\|amino-acid-N-acetyltransferase	unknown	unknown	gnl\|CDD\|236132
NC_013595.1\|WP_012895505.1\|10105182_10106274_+\|hypothetical-protein	unknown	unknown	unknown
NC_013595.1\|WP_031157992.1\|10098410_10098611_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|99777
NC_013595.1\|WP_081453367.1\|10087665_10088631_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NC_013595.1\|WP_012895491.1\|10084396_10085797_+\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|236994
NC_013595.1\|WP_148269873.1\|10102275_10104834_-\|L-aspartate-oxidase	unknown	unknown	gnl\|CDD\|236102
NC_013595.1\|WP_012895506.1\|10106368_10106797_-\|aspartate-1-decarboxylase	unknown	unknown	gnl\|CDD\|376751
NC_013595.1\|WP_012895497.1\|10092768_10093101_-\|Lsr2-family-protein	unknown	unknown	gnl\|CDD\|378714
NC_013595.1\|WP_012895507.1\|10107032_10107890_-\|pantoate--beta-alanine-ligase	unknown	unknown	gnl\|CDD\|234741
NC_013595.1\|WP_012895493.1\|10086977_10087643_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_013595.1\|WP_012895495.1\|10088687_10089638_-\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	1.28986e-10
NC_013595.1\|WP_012895490.1\|10083810_10084131_+\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	1.4563e-47
NC_013595.1\|WP_012895489.1\|10083439_10083814_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133388	cd01282, HTH_MerR-like_sg3, Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily. Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 3). Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	9.81971e-44
NC_013595.1\|WP_012895503.1\|10101493_10102276_-\|type-III-pantothenate-kinase	gnl\|CDD\|237347	PRK13318, PRK13318, type III pantothenate kinase.	2.49276e-147
NC_013595.1\|WP_012895500.1\|10097239_10098205_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	7.93556e-35
NC_013595.1\|WP_012895502.1\|10099966_10101469_-\|bifunctional-lysylphosphatidylglycerol-synthetase/lysine--tRNA-ligase-LysX	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NC_013595.1\|WP_012895492.1\|10085876_10086962_+\|DNA-integrity-scanning-protein-DisA	gnl\|CDD\|237395	PRK13482, PRK13482, DNA integrity scanning protein DisA; Provisional.	0
NC_013595.1\|WP_012895496.1\|10089995_10092503_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|214361	CHL00095, clpC, Clp protease ATP binding subunit.	0
NC_013595.1\|WP_169369513.1\|10098829_10099504_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.49484e-12
NC_013595.1\|WP_081453368.1\|10096002_10096659_-\|amino-acid-N-acetyltransferase	gnl\|CDD\|236132	PRK07922, PRK07922, amino-acid N-acetyltransferase.	3.036e-111
NC_013595.1\|WP_031157992.1\|10098410_10098611_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|99777	cd06170, LuxR_C_like, C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.	6.52212e-06
NC_013595.1\|WP_081453367.1\|10087665_10088631_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	1.62355e-87
NC_013595.1\|WP_012895491.1\|10084396_10085797_+\|DNA-repair-protein-RadA	gnl\|CDD\|236994	PRK11823, PRK11823, DNA repair protein RadA; Provisional.	0
NC_013595.1\|WP_148269873.1\|10102275_10104834_-\|L-aspartate-oxidase	gnl\|CDD\|236102	PRK07804, PRK07804, L-aspartate oxidase; Provisional.	0
NC_013595.1\|WP_012895506.1\|10106368_10106797_-\|aspartate-1-decarboxylase	gnl\|CDD\|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	4.05686e-79
NC_013595.1\|WP_012895497.1\|10092768_10093101_-\|Lsr2-family-protein	gnl\|CDD\|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	3.34603e-48
NC_013595.1\|WP_012895507.1\|10107032_10107890_-\|pantoate--beta-alanine-ligase	gnl\|CDD\|234741	PRK00380, panC, pantoate--beta-alanine ligase; Reviewed.	2.24686e-142

>NC_013595.1|WP_148269415.1|10093759_10094107_-|hypothetical-protein
MTLYRILSFYARLPHPSSRPAFYAAFRAIRPVGEGVLADPGPGSAVLPGLLARLIAFGGYTGYDYVPHAGGGRTLGKKAMKIRLVPYDGVAPRAAGPMKRAALQPGVLITAGIPW
>NC_013595.1|WP_012895497.1|10092768_10093101_-|Lsr2-family-protein
MAKQIQEILIDDLDGGEANETVAFAIDGTSYEIDLSDVNAKKLRDSLSPFVQSARRSGALAPRRRRAGGARALTREKSADIRAWAKSHGLNVSERGRIASKIVEQYEAAH
>NC_013595.1|WP_012895496.1|10089995_10092503_-|ATP-dependent-Clp-protease-ATP-binding-subunit
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKALESLGISLEGVRQQVEEIIGQGQSAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNRVRQQVIQLLHGYQGKEPAAAGGPQEAAPSTSLVLDQFGRNLTQAAREGKLDPVIGREKEIERVMQVLSRRTKNNPVLVGEPGVGKTAVVEGLSQKIVKGEVPETLKDKQLYTLDLGALVAGSRYRGDFEERLKKVLKEIRTRGDIILFIDELHTLVGAGAAEGAIDAASILKPMLARGELQTIGATTLDEYRKHLEKDAALERRFQPIQVAEPSLSHTIEILKGLRDRYEAHHRVSITDGALVAAAQLADRYISDRFLPDKAIDLIDEAGSRMRIRRMTAPPDLREYDEKIANVRRDKESAIDAQDFEKAAALRDQEKQLQLKRERREKEWKAGDMDVVAEVTEELIAEVLATATGIPVFKLTEEESQRLLRMEDELHKRIIGQDDAIKGLSRSIRRTRAGLKDPRRPGGSFIFAGPSGVGKTELSKALAEFLFGDEDALIMLDMSEFMEKHTVSRLFGSPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHPDIFNSLLQILEDGRLTDAQGRVVDFKNTVIIMTTNLGTRDISKGQGVGFAKSNDTESNYDRMKSKVQEELKQHFRPEFLNRVDDIVVFHQLTPKEIIKIVDLMLAQVGERLKDRDMGLEVTQDAKQLLADRGYDPVMGARPLRRTIQRELEDSLSEKILYGELRPGQIVKISIEGEGDNAKFVFVGEAAPADQVPDSAAAIAEPIQN
>NC_013595.1|WP_012895495.1|10088687_10089638_-|sugar-phosphate-isomerase/epimerase
MRLRHEDGTLVHLSYNAGVHPAEDLENLIAHLTRYAVPVRKRLGVERMGVGLWLSPSVADHLTADRIELVRLRRSLEERGLEVVSLNGTGGRNQDAPGPDWAKPERYRYTMALAKILAFLLPEDVRFGSISTIPIGWRRDWPADLHAIASRRLERLSRELRGLYSVTGKTIRVGFEPWPGCVLETTKQALERVGDIDSDHLGVCLDACHLAGGSEEPGAALRGLAAAGAPVVKLGHVHNHVSETRHELPSTRSVLEDTLTAMLSGAVNGTAHIEVETHDLAVPLRTRGPGALVDMLAEELDWARTNLTALGLRLAA
>NC_013595.1|WP_081453367.1|10087665_10088631_+|A/G-specific-adenine-glycosylase
MSDEGRPAATPAVSAGEEEGKAPARHYRREVPESNLLLEPVLDWYAESARDLPWRTPGASPWSILVSEIMLQQTPVVRVLPVWTEWMERWPTAAALAEEPPGEAVRHWGRLGYPRRALNLHACARAITDHHGGEVPSDHATLLTLPGIGEYTAAAVASFAFKGRHAVLDTNVRRVLARAVRGEEYPPKATTSAERRLAESLLPGADDAPVWAVAVMELGALVCTARAPRCADCPIGDLCAWRLAGKPAYDGPARKGQTYAGTDRQCRGRLLAVLRQAHGPVPKDALDVVWDIAPQRERALDGLIADGLAEVLDDGTYRLPG
>NC_013595.1|WP_012895493.1|10086977_10087643_-|hypothetical-protein
MDPDTFRSDIGVDVYWRRRMAALVGVLVVVAVVAWACSSSGPEDTSKVQAQLGGSPTPDPIVTVLPTVTVTPSPSPTTTSGSAKAAVRAKRPGDACESPDLVLNMQGQGDVYAPGSRPRFILTLVNIGKVTCTADVGPRAMEVRITSGSDRVWSSADCVSGEIDDIRKLDRGIPYVREIQWDRRRSGGDCTAERDDALAGTYVAVVRGPGLKSRRTVFHLR
>NC_013595.1|WP_012895492.1|10085876_10086962_+|DNA-integrity-scanning-protein-DisA
MPANYKGLDERRRAVLAAVAPGTALRDGLERILRGHTGGLIVLGHDSTVEEICSGGFELDVEFSATRLRELAKMDGAIVLNAGDLRIVRAAVHLMPDPSIPTDESGTRHRTAQRVAVQTSVPVISLSKSMRIIALYLDGFRYVLEESAAILSRANQALATLERYKLRLDEVSGTLSALEIEDLVTVRDIAVVAQRLEMVRRISEEIAGYVVELGTDGRLLSLQFDELVAGTETDRELIVRDYLPMAGRRPRKFAEALHDLDQLSSSDLLDLSVVAQVLGHSGNDALDSPVSPRGYRLLAKVPRLPGTVVDRLVDQFGSLQKLLAASIGDLQEVGGVGEARARHIREGLSRLAESSILERYV
>NC_013595.1|WP_012895491.1|10084396_10085797_+|DNA-repair-protein-RadA
MAKKVGYRCGECGWQTAKWVGRCGECQAWGTVEEETARGGVNVASAGAVSAPAVPIGQVKAEVAHARGTGVPELDRVLGGGLVPGAVVLLAGEPGIGKSTLLLEAAAKIARQQTVLYITGEESAAQVRVRADRIGAIQDQLYLAAETDLSALVAHVEKVQPDLLIVDSVQTIGSAQATGVPGGVTQVREVAGNLVRLAKERGMSTVLVGHVTKEGSIAGPRTLEHLVDVVLHFEGDRHSRLRMVRAIKNRYGPVDEVGCFDLHEGGIEGIADASGLFVSHRAEPVPGTCVTVTLEGTRPLPAEVQALVARTEAQQPRRSSSGLDTYRVTMVLAVLERRLNAKLGGCDVFTATVGGIKLSDPAVDLSVMLAVASAAGDKALPPGLVVMGEVGLAGELRPVRDVRRRLSEAARLGFTRALVPAGSLDAGKRKNGERSLVPVGGRSTNFLPGFDVVEADNVWDALTHVT
>NC_013595.1|WP_012895490.1|10083810_10084131_+|thioredoxin
MIMITLTAENFAEQVLQSDKPVLVDFWAEWCPPCRMIAPILEQIEAEHGDRVTIAKLNYDEHQEIAARYGVMGLPTLNLYKGGEVVQQIVGAKPKRMLLADLEDHI
>NC_013595.1|WP_012895489.1|10083439_10083814_+|MerR-family-transcriptional-regulator
MRIGELARRAGVSTRALRYYEQQGLITAGRKANGYREYGEADLKLVTEIRSLLGVGFTLEDARPFVACLRAGHASGGSCPESVAVYRRKLAEIDDEIRTLLARRAEVAGQLTESCHGCVLRKQR
>NC_013595.1|WP_081453368.1|10096002_10096659_-|amino-acid-N-acetyltransferase
MEQVAEHSPTPAVRDTEIAGRRAVAGGGDVDAERDPRDRPADAAEAAAEITVRRARTPDVRAIRRLVDTYGGAGPRLLEKATVTLYEDIQEFWVAERAGAVVGCGALHVLWEDLAEIRTVAVDPACRGLGIGHRIVSELIRTAGGLGLRRVFCLTFEVGFFARHGFREIQGTPVAPEVYAELLASYDEGVAEFLDLEHVKPNTLGNTRMLLHLTRDRD
>NC_013595.1|WP_012895500.1|10097239_10098205_+|C40-family-peptidase
MALIGLAFASLTLGTPVVAATADPKPSLPELAKQVEKLHTDIETLTEQYNGERVKLKQAQRAAASAKKTLAVSESELASRRAKATLLAQSSYMSGGLGAAMVFSQPTDPDTFLDQATTNYALQQQQSEEVAQVARAIEAAERAQASAKARTTEVKDLLSEIGTKRTKIEGLVDKVESDLFSEVRSRAKSNSRGSRVKISVPIVGSGKAAEAARWALSQQLKPYVWGAEGPNSFDCSGLVMWAYQKVGISLPHYTGDQWTAGTHISRDELRPGDLVFFYNDLHHVGIYIGAGLMVHAPRTGDVIHIASIDNRPFAGGVRVAD
>NC_013595.1|WP_031157992.1|10098410_10098611_-|LuxR-family-transcriptional-regulator
MGEIGLSDEDLVLLAELAKGVTVDRVGRRLDISGRTVRRRLRGICDRIGVATAIEAVAWAARRRLI
>NC_013595.1|WP_169369513.1|10098829_10099504_+|TetR-family-transcriptional-regulator
MPLRLSRGQAKARTRNRLLAAAAEVIAEQGFAGASVDEIASRAGHTVGALYSHFAGKDELFLTLFDEHAAHRLDSVEEIASQWEEDQTVFAALGEYLAEIADRHTVWSTLEMEFLRYALTRPELLDRLAAHWRAPRTAVARLVAPHCAAHDPVAVSTAIIGLLEGLVTQRRVDRAAVPSELFAEALRWLTAGLAHPPGPAAANPPQPPRPACREAGRKHAGRSS
>NC_013595.1|WP_012895502.1|10099966_10101469_-|bifunctional-lysylphosphatidylglycerol-synthetase/lysine--tRNA-ligase-LysX
MTDEVTNPAEDLPEQMRVRREKLDRLRSEGVDPYPVNFPRTATNGEIREKYADLAADTATGDRVGVTGRVMLSRTGGKLCFATIRDGSADLQVMISLDKVGEESLAAWKRDVDLGDHVGIEGEVITSRRGELSILADRWAITSKCLRPLPEKHAGLTDPEARVRQRYLDLIVNDEARKMAYTRSAVVRAMRDFWHGEGYLEVETPMLQPIHGGATARPFKTHINAYSMELYLRIAIELYLKRLVVGGIEKVFEINRNFRNEGADATHNPEFTMLEAYGTYLDYNDMADLTQRMIQSAVVAALGHSVVTHEGQEIDLGLPEWPRITLYGSVSEALGEEITTETPLEHVRKHADAHEIHWDPKWGQGKLVQEIFEALVEHTLIQPTFVMDYPLETSPLTRQHRDNPLLTEKWDLIGFGTELGTAYSELVDPVEQRRRLTEQSLLAAGGDPEAMQLDEDFLTALEYAMPPTGGMGLGVDRLVMAFTGKNIRETILFPLVKPAG
>NC_013595.1|WP_012895503.1|10101493_10102276_-|type-III-pantothenate-kinase
MLLAIDVGNTHTVLGLFEGDEVIEHWRIATDARRTADEIAVVLQGLLGQSPLLKGADVDGIALCSTVPSVLNEMREMCRRYYGDVTAVIVEPGIRTGVPVRMDNPKEVGSDRIVNALAAIQLYGGPCIIVDFGTATSFDAVSAKGEYIGAVTAPGIEISVDALAAAGAQLHKVELIRPRSVIAKNTVEALQSGIIYGFAGQVDGIVERMAAELADDPDDVTVVATGSAAPLVVSEARSIDVHEPWLTLIGLRLIYHRNTA
>NC_013595.1|WP_148269873.1|10102275_10104834_-|L-aspartate-oxidase
MAIPAIPQRLTAPAPGWTVEADVVVVGSGIAGLTLALRYAGLDPEAKVLVVTKDVLSSGSTRWAQGGIAAVLDPQDTPAEHLSDTLVAGVGLCDEEAVRVLVTEGPGALRGLIAAGARFDTDDSGELQLTREGGHRRNRIVHAGGDATGAEVQRALVQALRESSIEVIEHALVLDLLKDAGGRAAGVTLHVMGEGERDGVGAVRAGAVVLATGGMGQVYAATTNPVVSTGDGVALALRAGAVVRDLEFVQFHPTVLWLGEDSTGQQPLISEAVRGEGAVLVDAEGVRFMKDVHELADLAPRDVVAKAIMRRMRETGADHMYLDARHFGEEKWRTRFPTIHAVCREHGIDPVTQPIPVAPAAHYASGGVRADLHGRTSVPGLYACGEVACTGVHGANRLASNSLLEGLVFAERIAADIHAVRRAASPAAVRPAPGEPAADDRPTGLVDPRARPRIQGHMSRGASVLRGQDSLNEVARALVSTRWTPVAVEPCTESWEATNLLTVASALVEAARNREETRGSHWREDFPERNDAWWLGHLDVTLTAEGMTMTYVPHGQRATVLPPRVETDLIEAGLDPATVTALFRVAEDEDLQAPGDVTSLATIPAGQTDTADVVARADGVVSGLAVAEGAFSHLSQGRLTAERLVKDGERVTRGDVLMTVTGPTRDLLTAERTALNLLTHLSGIATLTDRWVRAVEGTGARIRDSRKTLPGLRALEKYAVRCGGGANHRMSLSDAALIKDNHVVAAGGVAEAFRAVRDAYPGLPIEVEVDRIDQIEPVLAEGAEEILLDNFTVDDLVLAVRLVDGRARLESSGGLTLDTARDVAETGVDYLAVGALTHSAPALDIALDLRGN
>NC_013595.1|WP_012895505.1|10105182_10106274_+|hypothetical-protein
MTREPESQQWREWDGGPELSRSWPSPHTDIDVDTAGLRKVGDAITMEVDGARGYESSALKPWRDMAVEVGHLDMITELDSLAWLDWTAFRALQWTLGLIGGRVTDGTQFALESYDSFGNMIFATSANYAMADSVFDKNISVLRYTVNGAGVRHQTSPTKEGWPGDDVSDYDAPKIKSMLSSIDVTSMLRKGCACADLATWLTSLQSLVEEHARQLAGAWRGEPAELALDAFRKVHATARALAHSVGTTGETIIWLANVIHRYQVNFESVVKLGDWEFDDDLPDWLLPSGGGAHDRARDYLRDLNQYVKAAYDMLPAEIETIVPTPRSEDAKSAYKGDGLKDGSDYWDSMITYNRPLDSGEPVY
>NC_013595.1|WP_012895506.1|10106368_10106797_-|aspartate-1-decarboxylase
MLRTMLTSKIHRATVTQADLHYVGSLTVDEDLLDAAGLLPGEQVHVVDIDNGARLVTYTIAGPRGSGIIGINGAAARLVHQGDLVIIIAYGQLDDAEARTFRPRVVHVDGGNRIVELGHDPASAPEPVTDLLRGDVLHRPAG
>NC_013595.1|WP_012895507.1|10107032_10107890_-|pantoate--beta-alanine-ligase
MDVIVAGDRAELAEARRALGIGGPASPGKAALALVPTMGALHEGHRSLMRLAGEHAEHVAVSIFVNPLQFGPGEDFSRYPRTFDDDLEVCAAEGVSMVFAPAAEDMYLPDRQVGVSAGKMGAVVEGAFRPGHLDGVLTVVLKLFNLVRPDVAVFGQKDAQQLAMIRRMVADLDLPISVVGAPTIREADGLALSSRNRYLSPQDRQAALALSRALFAGAGQRTPGEIRRVARAVLAEEPSVAVDYLVLVDPATFAEVGEGHTGEAILAVAARVGSTRLIDNVTIGL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_013595_17	17.1\|2342532\|17\|NC_013595\|CRISPRCasFinder	2342532-2342548	17	NC_013595.1	3333406-3333422	0	1.0
NC_013595_54	54.2\|9407760\|17\|NC_013595\|PILER-CR	9407760-9407776	17	NC_013595.1	9407803-9407819	0	1.0
NC_013595_54	54.2\|9407760\|17\|NC_013595\|PILER-CR	9407760-9407776	17	NC_013595.1	9407875-9407891	0	1.0
NC_013595_60	60.3\|10095130\|37\|NC_013595\|CRT	10095130-10095166	37	NC_013595.1	10095313-10095349	0	1.0
NC_013595_60	60.3\|10095130\|37\|NC_013595\|CRT	10095130-10095166	37	NC_013595.1	10095433-10095469	0	1.0
NC_013595_60	60.3\|10095130\|37\|NC_013595\|CRT	10095130-10095166	37	NC_013595.1	10095601-10095637	0	1.0
NC_013595_6	6.2\|563926\|32\|NC_013595\|CRISPRCasFinder	563926-563957	32	NC_013595.1	194137-194168	1	0.969
NC_013595_17	17.2\|2342574\|17\|NC_013595\|CRISPRCasFinder	2342574-2342590	17	NC_013595.1	6789406-6789422	1	0.941
NC_013595_23	23.1\|3141273\|23\|NC_013595\|PILER-CR	3141273-3141295	23	NC_013595.1	6244158-6244180	2	0.913
NC_013595_29	29.3\|4476045\|22\|NC_013595\|CRISPRCasFinder	4476045-4476066	22	NC_013595.1	2751023-2751044	2	0.909
NC_013595_29	29.3\|4476045\|22\|NC_013595\|CRISPRCasFinder	4476045-4476066	22	NC_013595.1	7834315-7834336	2	0.909

1. spacer 17.1|2342532|17|NC_013595|CRISPRCasFinder matches to position: 3333406-3333422, mismatch: 0, identity: 1.0

gggggtcggtccgggct	CRISPR spacer
gggggtcggtccgggct	Protospacer
*****************

2. spacer 54.2|9407760|17|NC_013595|PILER-CR matches to position: 9407803-9407819, mismatch: 0, identity: 1.0

ggcccgagggaccggaa	CRISPR spacer
ggcccgagggaccggaa	Protospacer
*****************

3. spacer 54.2|9407760|17|NC_013595|PILER-CR matches to position: 9407875-9407891, mismatch: 0, identity: 1.0

ggcccgagggaccggaa	CRISPR spacer
ggcccgagggaccggaa	Protospacer
*****************

4. spacer 60.3|10095130|37|NC_013595|CRT matches to position: 10095313-10095349, mismatch: 0, identity: 1.0

ggccggctgctgcccgtaggcgccggtcccctgctga	CRISPR spacer
ggccggctgctgcccgtaggcgccggtcccctgctga	Protospacer
*************************************

5. spacer 60.3|10095130|37|NC_013595|CRT matches to position: 10095433-10095469, mismatch: 0, identity: 1.0

ggccggctgctgcccgtaggcgccggtcccctgctga	CRISPR spacer
ggccggctgctgcccgtaggcgccggtcccctgctga	Protospacer
*************************************

6. spacer 60.3|10095130|37|NC_013595|CRT matches to position: 10095601-10095637, mismatch: 0, identity: 1.0

ggccggctgctgcccgtaggcgccggtcccctgctga	CRISPR spacer
ggccggctgctgcccgtaggcgccggtcccctgctga	Protospacer
*************************************

7. spacer 6.2|563926|32|NC_013595|CRISPRCasFinder matches to position: 194137-194168, mismatch: 1, identity: 0.969

cgcgttgcctcccacttcaggacagccccgta	CRISPR spacer
cgcgttgcctcccacttcaggacagacccgta	Protospacer
************************* ******

8. spacer 17.2|2342574|17|NC_013595|CRISPRCasFinder matches to position: 6789406-6789422, mismatch: 1, identity: 0.941

aggagcccgggacggtg	CRISPR spacer
aggggcccgggacggtg	Protospacer
***.*************

9. spacer 23.1|3141273|23|NC_013595|PILER-CR matches to position: 6244158-6244180, mismatch: 2, identity: 0.913

cgctgcgcggggtcgccgggatg	CRISPR spacer
cgctgctcgggctcgccgggatg	Protospacer
****** **** ***********

10. spacer 29.3|4476045|22|NC_013595|CRISPRCasFinder matches to position: 2751023-2751044, mismatch: 2, identity: 0.909

cgcgccggccgtcccgaccgcg	CRISPR spacer
cgtgccggccgtaccgaccgcg	Protospacer
**.********* *********

11. spacer 29.3|4476045|22|NC_013595|CRISPRCasFinder matches to position: 7834315-7834336, mismatch: 2, identity: 0.909

cgcgccggccgtcccgaccgcg	CRISPR spacer
cgcgccggccgtcccgctcgcg	Protospacer
**************** .****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_013595_29	29.3\|4476045\|22\|NC_013595\|CRISPRCasFinder	4476045-4476066	22	CP042595	Streptomyces albogriseolus strain LBX-2 plasmid pSALBX2, complete sequence	214228-214249	1	0.955
NC_013595_23	23.1\|3141273\|23\|NC_013595\|PILER-CR	3141273-3141295	23	NZ_CP016082	Streptomyces sp. SAT1 plasmid unnamed2, complete sequence	53216-53238	2	0.913
NC_013595_29	29.2\|4476000\|22\|NC_013595\|CRISPRCasFinder	4476000-4476021	22	NZ_CP029452	Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence	1970296-1970317	2	0.909
NC_013595_29	29.2\|4476000\|22\|NC_013595\|CRISPRCasFinder	4476000-4476021	22	NZ_CP014169	Sphingomonas panacis strain DCY99 plasmid unnamed, complete sequence	286924-286945	2	0.909
NC_013595_29	29.3\|4476045\|22\|NC_013595\|CRISPRCasFinder	4476045-4476066	22	LN997844	Streptomyces reticuli genome assembly TUE45, plasmid : III	72823-72844	2	0.909
NC_013595_1	1.1\|5715\|29\|NC_013595\|CRISPRCasFinder	5715-5743	29	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	4745829-4745857	4	0.862
NC_013595_19	19.2\|2473962\|25\|NC_013595\|CRISPRCasFinder	2473962-2473986	25	NZ_CP054617	Azospirillum oryzae strain KACC 14407 plasmid unnamed3, complete sequence	90789-90813	4	0.84
NC_013595_19	19.3\|2474013\|25\|NC_013595\|CRISPRCasFinder	2474013-2474037	25	NZ_CP033228	Sphingobium yanoikuyae strain SJTF8 plasmid pF2, complete sequence	169352-169376	4	0.84
NC_013595_19	19.3\|2474013\|25\|NC_013595\|CRISPRCasFinder	2474013-2474037	25	NC_009426	Novosphingobium aromaticivorans DSM 12444 plasmid pNL1, complete sequence	168618-168642	4	0.84
NC_013595_19	19.3\|2474013\|25\|NC_013595\|CRISPRCasFinder	2474013-2474037	25	NC_002033	Novosphingobium aromaticivorans plasmid pNL1, complete sequence	112007-112031	4	0.84
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	1470986-1471014	4	0.862
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	442102-442130	4	0.862
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	661386-661414	4	0.862
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	NC_004719	Streptomyces avermitilis MA-4680 = NBRC 14893 plasmid SAP1, complete sequence	70219-70245	4	0.852
NC_013595_24	24.2\|3382007\|27\|NC_013595\|CRISPRCasFinder	3382007-3382033	27	NZ_CP041043	Paracoccus sp. AK26 plasmid pAK3, complete sequence	69269-69295	4	0.852
NC_013595_24	24.2\|3382007\|27\|NC_013595\|CRISPRCasFinder	3382007-3382033	27	NZ_CP049158	Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence	1714767-1714793	4	0.852
NC_013595_24	24.2\|3382007\|27\|NC_013595\|CRISPRCasFinder	3382007-3382033	27	NZ_CP049318	Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence	1719435-1719461	4	0.852
NC_013595_59	59.1\|10050224\|25\|NC_013595\|CRISPRCasFinder	10050224-10050248	25	NC_031230	Gordonia phage Yvonnetastic, complete genome	20220-20244	4	0.84
NC_013595_59	59.1\|10050224\|25\|NC_013595\|CRISPRCasFinder	10050224-10050248	25	NZ_CP054841	Acidovorax sp. 16-35-5 plasmid unnamed1, complete sequence	411610-411634	4	0.84
NC_013595_59	59.1\|10050224\|25\|NC_013595\|CRISPRCasFinder	10050224-10050248	25	NZ_CP053905	Hymenobacter sp. BRD67 plasmid unnamed1, complete sequence	95074-95098	4	0.84
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	MT657333	Microbacterium phage Casend, complete genome	39997-40027	4	0.871
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP015585	Roseomonas gilardii strain U14-5 plasmid 1, complete sequence	77322-77350	5	0.828
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP021653	Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence	1287999-1288027	5	0.828
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP012688	Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence	1288006-1288034	5	0.828
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	CP047139	Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence	1214946-1214974	5	0.828
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	CP047137	Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence	1161524-1161552	5	0.828
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	298371-298399	5	0.828
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	679261-679289	5	0.828
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	MG872831	Mycobacterium phage Asriel, complete genome	69931-69957	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	MH399778	Mycobacterium phage Icee, complete genome	71526-71552	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	MN586051	Mycobacterium phage Myrale, complete genome	72446-72472	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	JF937106	Mycobacterium phage SirDuracell, complete genome	71827-71853	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	KR080204	Mycobacterium phage Mindy, complete genome	71503-71529	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	MG872832	Mycobacterium phage Barbarian, complete genome	69931-69957	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	MN586032	Mycobacterium phage Command613, complete genome	71711-71737	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	JF937096	Mycobacterium phage Henry, complete genome	72076-72102	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	MK937593	Mycobacterium phage Flypotenuse, complete genome	70585-70611	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	MN586013	Mycobacterium phage Traaww1, complete genome	70760-70786	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	KF306380	Mycobacterium phage DrDrey, complete genome	73406-73432	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	KY319168	Mycobacterium phage CrystalP, complete genome	72211-72237	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	JN006062	Mycobacterium phage Rakim, complete genome	71333-71359	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	NC_028785	Mycobacterium phage NelitzaMV, complete genome	69810-69836	5	0.815
NC_013595_24	24.1\|3381955\|27\|NC_013595\|CRISPRCasFinder	3381955-3381981	27	EU816591	Mycobacterium phage Kostya, complete genome	71750-71776	5	0.815
NC_013595_24	24.2\|3382007\|27\|NC_013595\|CRISPRCasFinder	3382007-3382033	27	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	917899-917925	5	0.815
NC_013595_36	36.1\|7296657\|28\|NC_013595\|CRISPRCasFinder	7296657-7296684	28	NC_003319	Streptomyces coelicolor plasmid 2 (SCP2*)	6681-6708	5	0.821
NC_013595_36	36.1\|7296657\|28\|NC_013595\|CRISPRCasFinder	7296657-7296684	28	NC_003904	Streptomyces coelicolor A3(2) plasmid SCP2, complete sequence	23969-23996	5	0.821
NC_013595_40	40.1\|7526433\|28\|NC_013595\|CRISPRCasFinder	7526433-7526460	28	NZ_CP013369	Burkholderia ubonensis strain RF23-BP41 plasmid pRF23, complete sequence	53985-54012	5	0.821
NC_013595_40	40.1\|7526433\|28\|NC_013595\|CRISPRCasFinder	7526433-7526460	28	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	1483325-1483352	5	0.821
NC_013595_40	40.1\|7526433\|28\|NC_013595\|CRISPRCasFinder	7526433-7526460	28	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	268880-268907	5	0.821
NC_013595_58	58.1\|9744965\|30\|NC_013595\|CRISPRCasFinder	9744965-9744994	30	MN617843	Mycobacterium phage Quesadilla, complete genome	30837-30866	5	0.833
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	MT114166	Microbacterium phage Nike, complete genome	39989-40019	5	0.839
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	MN183284	Microbacterium phage Mashley, complete genome	39466-39496	5	0.839
NC_013595_1	1.1\|5715\|29\|NC_013595\|CRISPRCasFinder	5715-5743	29	NZ_CP017887	Pseudomonas frederiksbergensis strain ERDD5:01 plasmid unnamed1, complete sequence	149872-149900	6	0.793
NC_013595_1	1.1\|5715\|29\|NC_013595\|CRISPRCasFinder	5715-5743	29	MK059749	Mycobacterium phage CRB2, complete genome	51617-51645	6	0.793
NC_013595_2	2.1\|123878\|29\|NC_013595\|CRISPRCasFinder	123878-123906	29	NC_019387	Thermus oshimai JL-2 plasmid pTHEOS01, complete sequence	7530-7558	6	0.793
NC_013595_4	4.1\|382155\|36\|NC_013595\|CRISPRCasFinder	382155-382190	36	NZ_LR134463	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 21, complete sequence	13288-13323	6	0.833
NC_013595_6	6.1\|563865\|32\|NC_013595\|CRISPRCasFinder	563865-563896	32	NZ_CP034812	Paracoccus sp. Arc7-R13 plasmid unnamed3, complete sequence	140686-140717	6	0.812
NC_013595_6	6.1\|563865\|32\|NC_013595\|CRISPRCasFinder	563865-563896	32	NZ_CP034813	Paracoccus sp. Arc7-R13 plasmid unnamed2, complete sequence	75779-75810	6	0.812
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	558851-558879	6	0.793
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	228442-228470	6	0.793
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1573538-1573566	6	0.793
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP035513	Haematobacter massiliensis strain OT1 plasmid pOT1-3, complete sequence	170682-170710	6	0.793
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP033321	Azospirillum brasilense strain Cd plasmid p3, complete sequence	291014-291042	6	0.793
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP012399	Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence	410455-410483	6	0.793
NC_013595_24	24.2\|3382007\|27\|NC_013595\|CRISPRCasFinder	3382007-3382033	27	NZ_CP022366	Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence	584394-584420	6	0.778
NC_013595_36	36.1\|7296657\|28\|NC_013595\|CRISPRCasFinder	7296657-7296684	28	MT310853	Microbacterium phage AvGardian, complete genome	40860-40887	6	0.786
NC_013595_58	58.1\|9744965\|30\|NC_013595\|CRISPRCasFinder	9744965-9744994	30	NZ_CP012185	Pseudonocardia sp. EC080619-01 plasmid pBCI1-2, complete sequence	738924-738953	6	0.8
NC_013595_58	58.1\|9744965\|30\|NC_013595\|CRISPRCasFinder	9744965-9744994	30	NZ_CP012182	Pseudonocardia sp. EC080610-09 plasmid pBCI2-1, complete sequence	309626-309655	6	0.8
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	EU307292	Burkholderia phage Bups phi1 clone 2 partial sequence	4711-4741	6	0.806
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	MH825699	Streptomyces phage Darolandstone, complete genome	34020-34050	6	0.806
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP009292	Novosphingobium pentaromativorans US6-1 plasmid pLA3, complete sequence	653301-653331	6	0.806
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_LR134450	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 8, complete sequence	77712-77742	6	0.806
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NC_008384	Rhizobium leguminosarum bv. viciae 3841 plasmid pRL11, complete sequence	633370-633400	6	0.806
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	MN304824	Catenulispora phage 69_17, complete genome	9844-9874	6	0.806
NC_013595_1	1.1\|5715\|29\|NC_013595\|CRISPRCasFinder	5715-5743	29	NZ_CP023072	Sinorhizobium fredii CCBAU 83666 plasmid pSF83666a, complete sequence	615109-615137	7	0.759
NC_013595_1	1.1\|5715\|29\|NC_013595\|CRISPRCasFinder	5715-5743	29	NC_018022	Mycolicibacterium chubuense NBB4 plasmid pMYCCH.01, complete sequence	427102-427130	7	0.759
NC_013595_1	1.1\|5715\|29\|NC_013595\|CRISPRCasFinder	5715-5743	29	NZ_CP029833	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence	209169-209197	7	0.759
NC_013595_1	1.1\|5715\|29\|NC_013595\|CRISPRCasFinder	5715-5743	29	NZ_CP023065	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence	100533-100561	7	0.759
NC_013595_13	13.1\|1720265\|31\|NC_013595\|CRISPRCasFinder	1720265-1720295	31	NZ_CP029777	Deinococcus actinosclerus strain Deinococcus actinosclerus SJTR plasmid unnamed3, complete sequence	409826-409856	7	0.774
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1058450-1058478	7	0.759
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1371471-1371499	7	0.759
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP015322	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence	633296-633324	7	0.759
NC_013595_40	40.1\|7526433\|28\|NC_013595\|CRISPRCasFinder	7526433-7526460	28	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	60679-60706	7	0.75
NC_013595_40	40.1\|7526433\|28\|NC_013595\|CRISPRCasFinder	7526433-7526460	28	NZ_LT703506	Mycobacterium chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera plasmid 2	47072-47099	7	0.75
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	MH825699	Streptomyces phage Darolandstone, complete genome	34002-34032	7	0.774
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP010864	Marinovum algicola DG 898 plasmid pMaD9, complete sequence	12806-12836	7	0.774
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_LR134465	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence	143901-143931	7	0.774
NC_013595_60	60.2\|10095073\|34\|NC_013595\|CRT	10095073-10095106	34	MH045568	Microbacterium phage Kieran, complete genome	6861-6894	7	0.794
NC_013595_60	60.2\|10095073\|34\|NC_013595\|CRT	10095073-10095106	34	MN062717	Microbacterium phage Sharkboy, complete genome	6857-6890	7	0.794
NC_013595_60	60.2\|10095073\|34\|NC_013595\|CRT	10095073-10095106	34	NC_042099	Microbacterium phage Dismas, complete genome	6858-6891	7	0.794
NC_013595_13	13.1\|1720265\|31\|NC_013595\|CRISPRCasFinder	1720265-1720295	31	NZ_CP012185	Pseudonocardia sp. EC080619-01 plasmid pBCI1-2, complete sequence	278737-278767	8	0.742
NC_013595_13	13.1\|1720265\|31\|NC_013595\|CRISPRCasFinder	1720265-1720295	31	NZ_CP012182	Pseudonocardia sp. EC080610-09 plasmid pBCI2-1, complete sequence	202108-202138	8	0.742
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP026091	Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence	1885502-1885530	8	0.724
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_LR134456	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 14, complete sequence	30471-30499	8	0.724
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP026093	Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence	1885682-1885710	8	0.724
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP039340	Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence	974217-974245	8	0.724
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	420441-420469	8	0.724
NC_013595_21	21.1\|2943188\|29\|NC_013595\|CRISPRCasFinder	2943188-2943216	29	MK977707	Mycobacterium phage LilSpotty, complete genome	28494-28522	8	0.724
NC_013595_26	26.1\|4140973\|31\|NC_013595\|CRISPRCasFinder	4140973-4141003	31	MT740734	Ralstonia phage Dina, complete genome	5399-5429	8	0.742
NC_013595_46	46.1\|8257040\|30\|NC_013595\|CRISPRCasFinder	8257040-8257069	30	NC_015169	Deinococcus proteolyticus MRP plasmid pDEIPR01, complete sequence	90031-90060	8	0.733
NC_013595_58	58.1\|9744965\|30\|NC_013595\|CRISPRCasFinder	9744965-9744994	30	NC_021289	Burkholderia insecticola plasmid p1, complete sequence	1051725-1051754	8	0.733
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP022775	Ralstonia solanacearum strain T12 plasmid unnamed, complete sequence	135618-135648	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NC_014310	Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence	131772-131802	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP022762	Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence	156328-156358	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP023017	Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence	136692-136722	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP014703	Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence	156328-156358	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP022760	Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence	129744-129774	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP022789	Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence	129745-129775	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP022771	Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence	156337-156367	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP022777	Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence	156355-156385	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP022799	Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence	156327-156357	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP022764	Ralstonia solanacearum strain T82 plasmid unnamed, complete sequence	135632-135662	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP022797	Ralstonia solanacearum strain SL2312 plasmid unnamed, complete sequence	135630-135660	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP022758	Ralstonia solanacearum strain T101 plasmid unnamed, complete sequence	135629-135659	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	MN694615	Marine virus AFVG_250M131, complete genome	9557-9587	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP016082	Streptomyces sp. SAT1 plasmid unnamed2, complete sequence	307429-307459	8	0.742
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_AP022607	Mycobacterium branderi strain JCM 12687 plasmid pJCM12687	346281-346311	8	0.742
NC_013595_26	26.1\|4140973\|31\|NC_013595\|CRISPRCasFinder	4140973-4141003	31	NZ_CP012699	Microbacterium sp. No. 7 plasmid B, complete sequence	68690-68720	9	0.71
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_LR134465	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence	143979-144009	9	0.71
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP054841	Acidovorax sp. 16-35-5 plasmid unnamed1, complete sequence	245772-245802	9	0.71
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP050082	Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence	659841-659871	9	0.71
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NC_008712	Paenarthrobacter aurescens TC1 plasmid pTC1, complete sequence	169574-169604	9	0.71
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP050099	Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence	415662-415692	9	0.71
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP053441	Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence	442866-442896	9	0.71
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP053208	Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1B, complete sequence	562412-562442	9	0.71
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	NZ_CP022366	Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence	54607-54637	9	0.71
NC_013595_60	60.1\|10095019\|31\|NC_013595\|CRT	10095019-10095049	31	MN855586	Bacteriophage sp. isolate 117, complete genome	1030-1060	9	0.71
NC_013595_5	5.1\|412406\|34\|NC_013595\|CRISPRCasFinder	412406-412439	34	MN657133	Cryobacterium sp. strain ANT_H10B plasmid pA10BH1, complete sequence	44692-44725	10	0.706
NC_013595_26	26.1\|4140973\|31\|NC_013595\|CRISPRCasFinder	4140973-4141003	31	NC_007949	Polaromonas sp. JS666 plasmid 1, complete sequence	281733-281763	10	0.677
NC_013595_5	5.1\|412406\|34\|NC_013595\|CRISPRCasFinder	412406-412439	34	MN693788	Marine virus AFVG_250M1061, complete genome	24831-24864	11	0.676
NC_013595_60	60.3\|10095130\|37\|NC_013595\|CRT	10095130-10095166	37	MH229865	Streptomyces phage LazerLemon, complete genome	17358-17394	12	0.676

1. spacer 29.3|4476045|22|NC_013595|CRISPRCasFinder matches to CP042595 (Streptomyces albogriseolus strain LBX-2 plasmid pSALBX2, complete sequence) position: , mismatch: 1, identity: 0.955

cgcgccggccgtcccgaccgcg	CRISPR spacer
agcgccggccgtcccgaccgcg	Protospacer
 *********************

2. spacer 23.1|3141273|23|NC_013595|PILER-CR matches to NZ_CP016082 (Streptomyces sp. SAT1 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.913

cgctgcgcggggtcgccgggatg	CRISPR spacer
cggtgcgcggggtcgccgggatc	Protospacer
** *******************

3. spacer 29.2|4476000|22|NC_013595|CRISPRCasFinder matches to NZ_CP029452 (Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence) position: , mismatch: 2, identity: 0.909

cgtcccgaccgcgccggccgtc	CRISPR spacer
tctcccgaccgcgccggccgtc	Protospacer
. ********************

4. spacer 29.2|4476000|22|NC_013595|CRISPRCasFinder matches to NZ_CP014169 (Sphingomonas panacis strain DCY99 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.909

cgtcccgaccgcgccggccgtc	CRISPR spacer
cgtcccgaccgcgccgggcgtg	Protospacer
***************** ***

5. spacer 29.3|4476045|22|NC_013595|CRISPRCasFinder matches to LN997844 (Streptomyces reticuli genome assembly TUE45, plasmid : III) position: , mismatch: 2, identity: 0.909

cgcgccggccgtcccgaccgcg	CRISPR spacer
cgcgccggccgtcccggccgcc	Protospacer
****************.****

6. spacer 1.1|5715|29|NC_013595|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 4, identity: 0.862

gacgaacacctcggagtcgggatcg-gcgt	CRISPR spacer
gacgagcacctcggtgtcgggatcgtacg-	Protospacer
*****.******** ********** .**

7. spacer 19.2|2473962|25|NC_013595|CRISPRCasFinder matches to NZ_CP054617 (Azospirillum oryzae strain KACC 14407 plasmid unnamed3, complete sequence) position: , mismatch: 4, identity: 0.84

gccgctctggggcggggcgtagccg	CRISPR spacer
gccgctggggggcggggcgtagctc	Protospacer
******  ***************.

8. spacer 19.3|2474013|25|NC_013595|CRISPRCasFinder matches to NZ_CP033228 (Sphingobium yanoikuyae strain SJTF8 plasmid pF2, complete sequence) position: , mismatch: 4, identity: 0.84

cgggtagacctggccggtctggggc	CRISPR spacer
ggggtagcccttgccggtctgggga	Protospacer
 ****** *** ************

9. spacer 19.3|2474013|25|NC_013595|CRISPRCasFinder matches to NC_009426 (Novosphingobium aromaticivorans DSM 12444 plasmid pNL1, complete sequence) position: , mismatch: 4, identity: 0.84

cgggtagacctggccggtctggggc	CRISPR spacer
ggggtagcccttgccggtctgggga	Protospacer
 ****** *** ************

10. spacer 19.3|2474013|25|NC_013595|CRISPRCasFinder matches to NC_002033 (Novosphingobium aromaticivorans plasmid pNL1, complete sequence) position: , mismatch: 4, identity: 0.84

cgggtagacctggccggtctggggc	CRISPR spacer
ggggtagcccttgccggtctgggga	Protospacer
 ****** *** ************

11. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 4, identity: 0.862

--tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
ggtggc--gacccggccggacgggcaggcgc	Protospacer
  * **  *.*********************

12. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 4, identity: 0.862

--tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
ggtggc--gacccggccggacgggcaggcgc	Protospacer
  * **  *.*********************

13. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 4, identity: 0.862

--tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
ggtggc--gacccggccggacgggcaggcgc	Protospacer
  * **  *.*********************

14. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to NC_004719 (Streptomyces avermitilis MA-4680 = NBRC 14893 plasmid SAP1, complete sequence) position: , mismatch: 4, identity: 0.852

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcctgtctcccgagccgatcacctgga	Protospacer
**  *** ***************.***

15. spacer 24.2|3382007|27|NC_013595|CRISPRCasFinder matches to NZ_CP041043 (Paracoccus sp. AK26 plasmid pAK3, complete sequence) position: , mismatch: 4, identity: 0.852

gtcggatggccggacgggtcagccgag	CRISPR spacer
aacggatggcctgacgggtccgccgag	Protospacer
. ********* ******** ******

16. spacer 24.2|3382007|27|NC_013595|CRISPRCasFinder matches to NZ_CP049158 (Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence) position: , mismatch: 4, identity: 0.852

gtcggatggccggacgggtcagccgag	CRISPR spacer
gacggatggcaggacgggccagccgaa	Protospacer
* ******** *******.*******.

17. spacer 24.2|3382007|27|NC_013595|CRISPRCasFinder matches to NZ_CP049318 (Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence) position: , mismatch: 4, identity: 0.852

gtcggatggccggacgggtcagccgag	CRISPR spacer
gacggatggcaggacgggccagccgaa	Protospacer
* ******** *******.*******.

18. spacer 59.1|10050224|25|NC_013595|CRISPRCasFinder matches to NC_031230 (Gordonia phage Yvonnetastic, complete genome) position: , mismatch: 4, identity: 0.84

gcgcgcccgtgctcacggccgggag	CRISPR spacer
ctgcgcccgtgctcacggcagggac	Protospacer
 .***************** ****

19. spacer 59.1|10050224|25|NC_013595|CRISPRCasFinder matches to NZ_CP054841 (Acidovorax sp. 16-35-5 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.84

gcgcgcccgtgctcacggccgggag	CRISPR spacer
gcgcgcccgagctcacggccgaggt	Protospacer
********* ***********.*.

20. spacer 59.1|10050224|25|NC_013595|CRISPRCasFinder matches to NZ_CP053905 (Hymenobacter sp. BRD67 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.84

gcgcgcccgtgctcacggccgggag	CRISPR spacer
tggcgcccgtgctcacggcggtgag	Protospacer
  ***************** * ***

21. spacer 60.1|10095019|31|NC_013595|CRT matches to MT657333 (Microbacterium phage Casend, complete genome) position: , mismatch: 4, identity: 0.871

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cccctgctgctgcacgtacgcctgctgctgc	Protospacer
* **********  ****************

22. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP015585 (Roseomonas gilardii strain U14-5 plasmid 1, complete sequence) position: , mismatch: 5, identity: 0.828

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
gcagcaggaccggccggacgggctggcgc	Protospacer
 *. **** ************** *****

23. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP021653 (Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.828

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
ccggaaggcccggccggccgggcaggtgc	Protospacer
.**  ************ ********.**

24. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP012688 (Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.828

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
ccggaaggcccggccggccgggcaggtgc	Protospacer
.**  ************ ********.**

25. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to CP047139 (Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.828

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
ccggaaggcccggccggccgggcaggtgc	Protospacer
.**  ************ ********.**

26. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to CP047137 (Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.828

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
ccggaaggcccggccggccgggcaggtgc	Protospacer
.**  ************ ********.**

27. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 5, identity: 0.828

--tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
ggtggc--gacccggccggacggtcaggcgc	Protospacer
  * **  *.************* *******

28. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.828

--tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
ggtggc--gacccggccggacggacaggcgc	Protospacer
  * **  *.*************.*******

29. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to MG872831 (Mycobacterium phage Asriel, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

30. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to MH399778 (Mycobacterium phage Icee, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

31. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to MN586051 (Mycobacterium phage Myrale, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

32. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to JF937106 (Mycobacterium phage SirDuracell, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

33. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to KR080204 (Mycobacterium phage Mindy, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

34. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to MG872832 (Mycobacterium phage Barbarian, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

35. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to MN586032 (Mycobacterium phage Command613, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

36. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to JF937096 (Mycobacterium phage Henry, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

37. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to MK937593 (Mycobacterium phage Flypotenuse, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

38. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to MN586013 (Mycobacterium phage Traaww1, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

39. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to KF306380 (Mycobacterium phage DrDrey, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

40. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to KY319168 (Mycobacterium phage CrystalP, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

41. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to JN006062 (Mycobacterium phage Rakim, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

42. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to NC_028785 (Mycobacterium phage NelitzaMV, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

43. spacer 24.1|3381955|27|NC_013595|CRISPRCasFinder matches to EU816591 (Mycobacterium phage Kostya, complete genome) position: , mismatch: 5, identity: 0.815

gcgggtcacccgagccgatcacccgga	CRISPR spacer
gcgggccacccgtgccgatcaccacgg	Protospacer
*****.****** **********  *.

44. spacer 24.2|3382007|27|NC_013595|CRISPRCasFinder matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.815

gtcggatggccggacgggtcagccgag	CRISPR spacer
ggcggatggccggattggtcagccgtc	Protospacer
* ************. *********

45. spacer 36.1|7296657|28|NC_013595|CRISPRCasFinder matches to NC_003319 (Streptomyces coelicolor plasmid 2 (SCP2*)) position: , mismatch: 5, identity: 0.821

ccggaaggccccctcggacgaccgcttc	CRISPR spacer
ccgcaaggccccctcggacgtccggctg	Protospacer
*** **************** *** .*

46. spacer 36.1|7296657|28|NC_013595|CRISPRCasFinder matches to NC_003904 (Streptomyces coelicolor A3(2) plasmid SCP2, complete sequence) position: , mismatch: 5, identity: 0.821

ccggaaggccccctcggacgaccgcttc	CRISPR spacer
ccgcaaggccccctcggacgtccggctg	Protospacer
*** **************** *** .*

47. spacer 40.1|7526433|28|NC_013595|CRISPRCasFinder matches to NZ_CP013369 (Burkholderia ubonensis strain RF23-BP41 plasmid pRF23, complete sequence) position: , mismatch: 5, identity: 0.821

gaccggagatccggccggccccggcacg	CRISPR spacer
cggcggaggtccgggcggccccggcacg	Protospacer
 . *****.***** *************

48. spacer 40.1|7526433|28|NC_013595|CRISPRCasFinder matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 5, identity: 0.821

gaccggagatccggccggccccggcacg	CRISPR spacer
gcccggagatccggctggccacggcatc	Protospacer
* *************.**** *****.

49. spacer 40.1|7526433|28|NC_013595|CRISPRCasFinder matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 5, identity: 0.821

gaccggagatccggccggccccggcacg	CRISPR spacer
gcccggagatccggctggccacggcatc	Protospacer
* *************.**** *****.

50. spacer 58.1|9744965|30|NC_013595|CRISPRCasFinder matches to MN617843 (Mycobacterium phage Quesadilla, complete genome) position: , mismatch: 5, identity: 0.833

gctcggggcgcggacggggatcg-ggctcca	CRISPR spacer
gctcggcgcgcggccggggatcgtggctgt-	Protospacer
****** ****** ********* **** .

51. spacer 60.1|10095019|31|NC_013595|CRT matches to MT114166 (Microbacterium phage Nike, complete genome) position: , mismatch: 5, identity: 0.839

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cccctgctgctgcacgtacgcctgctgcggc	Protospacer
* **********  ************** *

52. spacer 60.1|10095019|31|NC_013595|CRT matches to MN183284 (Microbacterium phage Mashley, complete genome) position: , mismatch: 5, identity: 0.839

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cccctgctgctgcacgtacgcctgctgcggc	Protospacer
* **********  ************** *

53. spacer 1.1|5715|29|NC_013595|CRISPRCasFinder matches to NZ_CP017887 (Pseudomonas frederiksbergensis strain ERDD5:01 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.793

gacgaacacctcggagtcgggatcggcgt	CRISPR spacer
ccggaacacctcggcgtcgggatctgcct	Protospacer
   *********** ********* ** *

54. spacer 1.1|5715|29|NC_013595|CRISPRCasFinder matches to MK059749 (Mycobacterium phage CRB2, complete genome) position: , mismatch: 6, identity: 0.793

gacgaacacctcggagtcgggatcggcgt	CRISPR spacer
gtcgaacacgtcggggtcgggatcgtcca	Protospacer
* ******* ****.********** *

55. spacer 2.1|123878|29|NC_013595|CRISPRCasFinder matches to NC_019387 (Thermus oshimai JL-2 plasmid pTHEOS01, complete sequence) position: , mismatch: 6, identity: 0.793

gatggagtggccgggggccggcccatcca	CRISPR spacer
ggggggcaggcggggggccggcccatcca	Protospacer
*. **.  *** *****************

56. spacer 4.1|382155|36|NC_013595|CRISPRCasFinder matches to NZ_LR134463 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 21, complete sequence) position: , mismatch: 6, identity: 0.833

gcgagcc-cgacggtccagaagtcggcgtcgcgctcc	CRISPR spacer
-tgcgccgggacgatccagaagtcggcgtcgggctcc	Protospacer
 .* ***  ****.***************** *****

57. spacer 6.1|563865|32|NC_013595|CRISPRCasFinder matches to NZ_CP034812 (Paracoccus sp. Arc7-R13 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.812

gatcacgcccgagggcagatcaccgataccgg---	CRISPR spacer
catcacgcccgcgggcagatcgcc---accgggat	Protospacer
 ********** *********.**   *****

58. spacer 6.1|563865|32|NC_013595|CRISPRCasFinder matches to NZ_CP034813 (Paracoccus sp. Arc7-R13 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.812

gatcacgcccgagggcagatcaccgataccgg---	CRISPR spacer
catcacgcccgcgggcagatcgcc---accgggat	Protospacer
 ********** *********.**   *****

59. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.793

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
gctccaggcccggccggacgcgctggagt	Protospacer
 * ***************** ** ** *.

60. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 6, identity: 0.793

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
cgagcaggtccggccggacgggctggcgc	Protospacer
. . ****.************** *****

61. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 6, identity: 0.793

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
gctccaggcccggccggacgcgctggagt	Protospacer
 * ***************** ** ** *.

62. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP035513 (Haematobacter massiliensis strain OT1 plasmid pOT1-3, complete sequence) position: , mismatch: 6, identity: 0.793

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
ttcgcaggcccagccgggcgggcaggcga	Protospacer
*.  *******.*****.**********

63. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP033321 (Azospirillum brasilense strain Cd plasmid p3, complete sequence) position: , mismatch: 6, identity: 0.793

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
gctccaggcccggccggacgcgctggagt	Protospacer
 * ***************** ** ** *.

64. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP012399 (Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence) position: , mismatch: 6, identity: 0.793

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
ttcaccggcccggccggacgggcgagcgc	Protospacer
*.  * *****************..****

65. spacer 24.2|3382007|27|NC_013595|CRISPRCasFinder matches to NZ_CP022366 (Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence) position: , mismatch: 6, identity: 0.778

gtcggatggccggacgggtcagccgag	CRISPR spacer
aacggctggccggacggatcagccgca	Protospacer
. *** ***********.******* .

66. spacer 36.1|7296657|28|NC_013595|CRISPRCasFinder matches to MT310853 (Microbacterium phage AvGardian, complete genome) position: , mismatch: 6, identity: 0.786

ccggaaggccccctcggacgaccgcttc	CRISPR spacer
atggaaggccccctcggatgacctccgc	Protospacer
 .****************.**** *. *

67. spacer 58.1|9744965|30|NC_013595|CRISPRCasFinder matches to NZ_CP012185 (Pseudonocardia sp. EC080619-01 plasmid pBCI1-2, complete sequence) position: , mismatch: 6, identity: 0.8

gctcggggcgcggacggggatcgggctcca	CRISPR spacer
gctcggcgcgcggacggcgatcggcccgcc	Protospacer
****** ********** ****** *. *

68. spacer 58.1|9744965|30|NC_013595|CRISPRCasFinder matches to NZ_CP012182 (Pseudonocardia sp. EC080610-09 plasmid pBCI2-1, complete sequence) position: , mismatch: 6, identity: 0.8

gctcggggcgcggacggggatcgggctcca	CRISPR spacer
gctcggcgcgcggacggcgatcggcccgcc	Protospacer
****** ********** ****** *. *

69. spacer 60.1|10095019|31|NC_013595|CRT matches to EU307292 (Burkholderia phage Bups phi1 clone 2 partial sequence) position: , mismatch: 6, identity: 0.806

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cgcctgccgctggccgaacgcctgctgtacg	Protospacer
*******.******** **********.  .

70. spacer 60.1|10095019|31|NC_013595|CRT matches to MH825699 (Streptomyces phage Darolandstone, complete genome) position: , mismatch: 6, identity: 0.806

cgcctg---ctgctggccgtacgcctgctgctga	CRISPR spacer
---ctgggcctgctggccgtatccctgctgctgg	Protospacer
   ***   ************. **********.

71. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP009292 (Novosphingobium pentaromativorans US6-1 plasmid pLA3, complete sequence) position: , mismatch: 6, identity: 0.806

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
ggcagcctgctggccgtgggcctgctgctga	Protospacer
 **   ***********. ************

72. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_LR134450 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 8, complete sequence) position: , mismatch: 6, identity: 0.806

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
gtcgtactgctggccgtacggctgctgcgga	Protospacer
  * *.************** ******* **

73. spacer 60.1|10095019|31|NC_013595|CRT matches to NC_008384 (Rhizobium leguminosarum bv. viciae 3841 plasmid pRL11, complete sequence) position: , mismatch: 6, identity: 0.806

cgcctgctgctggccgtacgcctg-ctgctga	CRISPR spacer
ggcctgctgctggccgcaggcctgattggtg-	Protospacer
 ***************.* ***** .** **

74. spacer 60.1|10095019|31|NC_013595|CRT matches to MN304824 (Catenulispora phage 69_17, complete genome) position: , mismatch: 6, identity: 0.806

cgcctgctgctggccgtacgcctgctgctga--	CRISPR spacer
ggcctgctgctcggcgtacgcctg--gcggacc	Protospacer
 ********** * **********  ** **

75. spacer 1.1|5715|29|NC_013595|CRISPRCasFinder matches to NZ_CP023072 (Sinorhizobium fredii CCBAU 83666 plasmid pSF83666a, complete sequence) position: , mismatch: 7, identity: 0.759

gacgaacacctcggagtcgggatcggcgt	CRISPR spacer
ggtacagtcctcggcgtcgggatcggcgt	Protospacer
*... *  ****** **************

76. spacer 1.1|5715|29|NC_013595|CRISPRCasFinder matches to NC_018022 (Mycolicibacterium chubuense NBB4 plasmid pMYCCH.01, complete sequence) position: , mismatch: 7, identity: 0.759

gacgaacacctcggagtcgggatcggcgt	CRISPR spacer
gtcgaacaccgcggagtcgggaccgaacg	Protospacer
* ******** ***********.**.

77. spacer 1.1|5715|29|NC_013595|CRISPRCasFinder matches to NZ_CP029833 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.759

gacgaacacctcggagtcgggatcggcgt	CRISPR spacer
gacgaacacctcggcgtcgggcctcacat	Protospacer
************** ****** .. .*.*

78. spacer 1.1|5715|29|NC_013595|CRISPRCasFinder matches to NZ_CP023065 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence) position: , mismatch: 7, identity: 0.759

gacgaacacctcggagtcgggatcggcgt	CRISPR spacer
ggtacagtcctcggcgtcgggatcggcgt	Protospacer
*... *  ****** **************

79. spacer 13.1|1720265|31|NC_013595|CRISPRCasFinder matches to NZ_CP029777 (Deinococcus actinosclerus strain Deinococcus actinosclerus SJTR plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.774

--gcatcggcccgccacccgcacgttccgccac	CRISPR spacer
caggttca--ccgccacccgcacgtccggccac	Protospacer
  *  **.  ***************.* *****

80. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 7, identity: 0.759

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
gctccaggcccggccggacgcgctggatt	Protospacer
 * ***************** ** **  .

81. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.759

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
gctccaggcccggccggacgcgctggact	Protospacer
 * ***************** ** **  .

82. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP015322 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence) position: , mismatch: 7, identity: 0.759

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
catcgaggccgggccggacgggcaggtcc	Protospacer
.  * ***** ***************. *

83. spacer 40.1|7526433|28|NC_013595|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 7, identity: 0.75

gaccggagatccggccggccccggcacg	CRISPR spacer
tcacggagatccggccggcctcggcgga	Protospacer
   *****************.****. .

84. spacer 40.1|7526433|28|NC_013595|CRISPRCasFinder matches to NZ_LT703506 (Mycobacterium chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera plasmid 2) position: , mismatch: 7, identity: 0.75

gaccggagatccggccggccccggcacg	CRISPR spacer
cgtcggcgctccggccggccccggcagt	Protospacer
 ..*** * *****************

85. spacer 60.1|10095019|31|NC_013595|CRT matches to MH825699 (Streptomyces phage Darolandstone, complete genome) position: , mismatch: 7, identity: 0.774

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
tccctgctgctggccgtacgactgctgtccg	Protospacer
. ****************** ******.. .

86. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP010864 (Marinovum algicola DG 898 plasmid pMaD9, complete sequence) position: , mismatch: 7, identity: 0.774

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
ccgctgctgctggccggactcctgctgtggc	Protospacer
*  ************* ** *******. *

87. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_LR134465 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence) position: , mismatch: 7, identity: 0.774

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
gccgtactgctggccgtagccctgctgctgc	Protospacer
  * *.************  **********

88. spacer 60.2|10095073|34|NC_013595|CRT matches to MH045568 (Microbacterium phage Kieran, complete genome) position: , mismatch: 7, identity: 0.794

gcccggctgggagggctggccgtagggggactgc	CRISPR spacer
gtcggcctgggagggctggccgtcggcggacttg	Protospacer
*.* * ***************** ** *****

89. spacer 60.2|10095073|34|NC_013595|CRT matches to MN062717 (Microbacterium phage Sharkboy, complete genome) position: , mismatch: 7, identity: 0.794

gcccggctgggagggctggccgtagggggactgc	CRISPR spacer
gtcggcctgggagggctggccgtcggcggacttg	Protospacer
*.* * ***************** ** *****

90. spacer 60.2|10095073|34|NC_013595|CRT matches to NC_042099 (Microbacterium phage Dismas, complete genome) position: , mismatch: 7, identity: 0.794

gcccggctgggagggctggccgtagggggactgc	CRISPR spacer
gtcggcctgggagggctggccgtcggcggacttg	Protospacer
*.* * ***************** ** *****

91. spacer 13.1|1720265|31|NC_013595|CRISPRCasFinder matches to NZ_CP012185 (Pseudonocardia sp. EC080619-01 plasmid pBCI1-2, complete sequence) position: , mismatch: 8, identity: 0.742

gcatcggcccgccacccgcacgttccgccac	CRISPR spacer
gcccgtcaccgccacccgcaagttccgcaac	Protospacer
** .    ************ ******* **

92. spacer 13.1|1720265|31|NC_013595|CRISPRCasFinder matches to NZ_CP012182 (Pseudonocardia sp. EC080610-09 plasmid pBCI2-1, complete sequence) position: , mismatch: 8, identity: 0.742

gcatcggcccgccacccgcacgttccgccac	CRISPR spacer
gcccgtcaccgccacccgcaagttccgcaac	Protospacer
** .    ************ ******* **

93. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP026091 (Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.724

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
gggggtggcctggccggacgggcaggcca	Protospacer
  *   ****.****************

94. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_LR134456 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 14, complete sequence) position: , mismatch: 8, identity: 0.724

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
tcgccaggcacggcccgacgggctccttg	Protospacer
********* ***** *******   .

95. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP026093 (Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.724

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
gggggtggcctggccggacgggcaggcca	Protospacer
  *   ****.****************

96. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP039340 (Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence) position: , mismatch: 8, identity: 0.724

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
gggggtggcctggccggacgggcaggcca	Protospacer
  *   ****.****************

97. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.724

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
cgaccaggcccggccggaacggcaggaag	Protospacer
. .***************  ****** .

98. spacer 21.1|2943188|29|NC_013595|CRISPRCasFinder matches to MK977707 (Mycobacterium phage LilSpotty, complete genome) position: , mismatch: 8, identity: 0.724

tcgccaggcccggccggacgggcaggcgc	CRISPR spacer
ggagaaggcccgggcggacgggctggcga	Protospacer
  .  ******** ********* ****

99. spacer 26.1|4140973|31|NC_013595|CRISPRCasFinder matches to MT740734 (Ralstonia phage Dina, complete genome) position: , mismatch: 8, identity: 0.742

gggctt---ggcggtcggaggcgacgagctcgct	CRISPR spacer
---tttgcaggcggtcgaaggcggcgagctcgag	Protospacer
   .**   ********.*****.********

100. spacer 46.1|8257040|30|NC_013595|CRISPRCasFinder matches to NC_015169 (Deinococcus proteolyticus MRP plasmid pDEIPR01, complete sequence) position: , mismatch: 8, identity: 0.733

aggtggccgggggccatccctttcgtgcag	CRISPR spacer
aggtggccggtggccgtccctttatcgagc	Protospacer
********** ****.*******  .* .

101. spacer 58.1|9744965|30|NC_013595|CRISPRCasFinder matches to NC_021289 (Burkholderia insecticola plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.733

gctcggggcgcggacggggatcgggctcca	CRISPR spacer
gctcggggcgcggacagggatggcataaaa	Protospacer
***************.***** * ..   *

102. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP022775 (Ralstonia solanacearum strain T12 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

103. spacer 60.1|10095019|31|NC_013595|CRT matches to NC_014310 (Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

104. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP022762 (Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

105. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP023017 (Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

106. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP014703 (Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

107. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP022760 (Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

108. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP022789 (Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

109. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP022771 (Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

110. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP022777 (Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

111. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP022799 (Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

112. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP022764 (Ralstonia solanacearum strain T82 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

113. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP022797 (Ralstonia solanacearum strain SL2312 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

114. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP022758 (Ralstonia solanacearum strain T101 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cattcgctgctggccgtgcgcctgctgtcgc	Protospacer
*....************.*********..*

115. spacer 60.1|10095019|31|NC_013595|CRT matches to MN694615 (Marine virus AFVG_250M131, complete genome) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
agacttctgctggccgtacgcctgatgagac	Protospacer
 * ** ****************** **  .

116. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP016082 (Streptomyces sp. SAT1 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
gaaccgccgatggccgtacgcctgctgcggc	Protospacer
 . *.**.* ****************** *

117. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_AP022607 (Mycobacterium branderi strain JCM 12687 plasmid pJCM12687) position: , mismatch: 8, identity: 0.742

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
cgggtgctgctggccgtaaggctgctggccg	Protospacer
**  ************** * ****** . .

118. spacer 26.1|4140973|31|NC_013595|CRISPRCasFinder matches to NZ_CP012699 (Microbacterium sp. No. 7 plasmid B, complete sequence) position: , mismatch: 9, identity: 0.71

gggcttggcggtcggaggcgacgagctcgct	CRISPR spacer
tgcgccggcgctcggtggcgacgagctcgag	Protospacer
 *  ..**** **** *************

119. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_LR134465 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence) position: , mismatch: 9, identity: 0.71

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
atcgggctgctggccgtagccctgctgcgcg	Protospacer
  *  *************  ********  .

120. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP054841 (Acidovorax sp. 16-35-5 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.71

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
gagctgctgctgggcgcacgcctgctggccg	Protospacer
 . ********** **.********** . .

121. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP050082 (Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence) position: , mismatch: 9, identity: 0.71

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
ggcctgctgctggccgcaggcctgatcggcg	Protospacer
 ***************.* ***** *    .

122. spacer 60.1|10095019|31|NC_013595|CRT matches to NC_008712 (Paenarthrobacter aurescens TC1 plasmid pTC1, complete sequence) position: , mismatch: 9, identity: 0.71

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
gctatcgtgctggccgtgtgcctgctgctgg	Protospacer
  . *  **********..***********.

123. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP050099 (Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence) position: , mismatch: 9, identity: 0.71

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
ggcctgctgctggccgcaggcctgatcggcg	Protospacer
 ***************.* ***** *    .

124. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP053441 (Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence) position: , mismatch: 9, identity: 0.71

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
ggcctgctgctggccgcaggcctgatcggcg	Protospacer
 ***************.* ***** *    .

125. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP053208 (Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1B, complete sequence) position: , mismatch: 9, identity: 0.71

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
ggcctgctgctggccgcaggcctgatcggcg	Protospacer
 ***************.* ***** *    .

126. spacer 60.1|10095019|31|NC_013595|CRT matches to NZ_CP022366 (Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence) position: , mismatch: 9, identity: 0.71

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
gggctgctgctggccgaactcctgctcgacg	Protospacer
 * ************* ** ******    .

127. spacer 60.1|10095019|31|NC_013595|CRT matches to MN855586 (Bacteriophage sp. isolate 117, complete genome) position: , mismatch: 9, identity: 0.71

cgcctgctgctggccgtacgcctgctgctga	CRISPR spacer
gagttgctgctggccgaacgcttgctgtggc	Protospacer
 . .************ ****.*****. *

128. spacer 5.1|412406|34|NC_013595|CRISPRCasFinder matches to MN657133 (Cryobacterium sp. strain ANT_H10B plasmid pA10BH1, complete sequence) position: , mismatch: 10, identity: 0.706

cgggtgggccgccgtctgggcccggtcgt-cgacg	CRISPR spacer
gttccgggccgcggtctgcgcccggtcgtgcggt-	Protospacer
    .******* ***** ********** **..

129. spacer 26.1|4140973|31|NC_013595|CRISPRCasFinder matches to NC_007949 (Polaromonas sp. JS666 plasmid 1, complete sequence) position: , mismatch: 10, identity: 0.677

gggcttggcggtcggaggcgacgagctcgct	CRISPR spacer
taagaaagcggtcgaagccgacgagctcgcg	Protospacer
 ..   .*******.** ************

130. spacer 5.1|412406|34|NC_013595|CRISPRCasFinder matches to MN693788 (Marine virus AFVG_250M1061, complete genome) position: , mismatch: 11, identity: 0.676

cgggtgggccgccgtctgggcccggtcgtcgacg	CRISPR spacer
ggggtggtccgccgtctgggctcggctccccgtc	Protospacer
 ****** *************.***.. .* ..

131. spacer 60.3|10095130|37|NC_013595|CRT matches to MH229865 (Streptomyces phage LazerLemon, complete genome) position: , mismatch: 12, identity: 0.676

ggccggctgctgcccgtaggcgccggtcccctgctga	CRISPR spacer
cttgagctgctgcgcgtaggcgtcggtccccggggtg	Protospacer
  . .******** ********.******** *   .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

151567 : 213991

Streptomyces_phage(33.33%)

integrase,transposase,protease

attL 166845:166863|attR 204391:204409

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012886948.1\|151567_152938_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_043654382.1\|152934_153105_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_169369521.1\|153125_154766_-	replication initiation protein	NA	NA	NA	NA
WP_012886951.1\|154855_155032_-	hypothetical protein	NA	NA	NA	NA
WP_012886952.1\|155031_156477_-	cell division protein FtsK	NA	NA	NA	NA
WP_012886953.1\|156566_156998_-	hypothetical protein	NA	NA	NA	NA
WP_012886954.1\|157110_157848_-	GntR family transcriptional regulator	A0A291LID1	Streptomyces_phage	4.9e-10	47.9
WP_012886955.1\|158298_158613_-	hypothetical protein	NA	NA	NA	NA
WP_012886956.1\|158905_159691_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_012886957.1\|159763_160213_+	NUDIX domain-containing protein	A0A0F6YPF5	Sinorhizobium_phage	1.7e-05	35.7
WP_012886958.1\|160628_161891_-	SEC-C domain-containing protein	NA	NA	NA	NA
WP_148268905.1\|161944_164233_-	hypothetical protein	NA	NA	NA	NA
WP_043651045.1\|166059_166383_-	hypothetical protein	NA	NA	NA	NA
166845:166863	attL	NA	NA	NA	NA
WP_012886961.1\|167089_167446_+	hypothetical protein	NA	NA	NA	NA
WP_012886963.1\|168279_169242_+	ankyrin repeat domain-containing protein	NA	NA	NA	NA
WP_148269430.1\|169593_171033_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012886965.1\|171029_172919_+	hypothetical protein	NA	NA	NA	NA
WP_012886966.1\|172915_174997_+	hypothetical protein	NA	NA	NA	NA
WP_012886967.1\|174993_175392_+	hypothetical protein	NA	NA	NA	NA
WP_169369210.1\|175353_175593_-\|transposase	transposase	NA	NA	NA	NA
WP_012886968.1\|175697_176900_-	hypothetical protein	NA	NA	NA	NA
WP_148268906.1\|176940_177516_-	YceI family protein	NA	NA	NA	NA
WP_012886970.1\|178092_178485_+	hypothetical protein	NA	NA	NA	NA
WP_012886971.1\|178632_179286_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_043651052.1\|179437_179683_+	hypothetical protein	NA	NA	NA	NA
WP_012886972.1\|179802_180663_-	hypothetical protein	NA	NA	NA	NA
WP_012886974.1\|180999_181323_+	hypothetical protein	NA	NA	NA	NA
WP_012886975.1\|181420_181807_-	hypothetical protein	NA	NA	NA	NA
WP_148268907.1\|181810_182233_-	hypothetical protein	NA	NA	NA	NA
WP_012886977.1\|182568_183021_-	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_012886978.1\|183158_183776_+	LysE family translocator	NA	NA	NA	NA
WP_012886979.1\|183944_184670_-	hypothetical protein	NA	NA	NA	NA
WP_012886980.1\|184853_185423_+	cadmium resistance transporter	NA	NA	NA	NA
WP_012886981.1\|185475_186285_+\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_169369212.1\|186414_187308_-	TIGR03943 family protein	NA	NA	NA	NA
WP_012886983.1\|187313_188345_-	permease	NA	NA	NA	NA
WP_012886984.1\|188388_189252_-	NUDIX hydrolase	NA	NA	NA	NA
WP_012886985.1\|189494_190223_-	M15 family metallopeptidase	NA	NA	NA	NA
WP_012886986.1\|190908_192090_+	AAA family ATPase	NA	NA	NA	NA
WP_012886987.1\|192211_193051_-	hypothetical protein	NA	NA	NA	NA
WP_012886988.1\|193056_194007_-	hypothetical protein	NA	NA	NA	NA
WP_012886989.1\|194255_194825_+	SigE family RNA polymerase sigma factor	NA	NA	NA	NA
WP_081452994.1\|194901_195471_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012886991.1\|195482_196046_+	YceI family protein	NA	NA	NA	NA
WP_081452995.1\|196492_196846_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012886993.1\|197397_197982_-	SMI1/KNR4 family protein	NA	NA	NA	NA
WP_012886994.1\|198183_198825_-	response regulator transcription factor	NA	NA	NA	NA
WP_169369214.1\|198821_200087_-	sensor histidine kinase	NA	NA	NA	NA
WP_012886996.1\|200095_201073_-	hypothetical protein	NA	NA	NA	NA
WP_012886997.1\|201101_201350_+	hypothetical protein	NA	NA	NA	NA
WP_012886998.1\|203845_204331_+	hypothetical protein	NA	NA	NA	NA
WP_043651062.1\|204612_204936_+	hypothetical protein	NA	NA	NA	NA
204391:204409	attR	NA	NA	NA	NA
WP_012886999.1\|205825_207619_+	hypothetical protein	NA	NA	NA	NA
WP_043651070.1\|208138_208321_-	hypothetical protein	NA	NA	NA	NA
WP_043651074.1\|208465_208813_-	hypothetical protein	NA	NA	NA	NA
WP_043651077.1\|208862_209468_-	hypothetical protein	NA	NA	NA	NA
WP_012887001.1\|210234_211008_-	ABC transporter permease	NA	NA	NA	NA
WP_012887002.1\|211004_211943_-	daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein	A0A2R8FG22	Brazilian_cedratvirus	3.1e-17	32.5
WP_012887003.1\|211968_212640_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_012887004.1\|213361_213991_-\|transposase	Tn3 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

4733265 : 4760444

Mycobacterium_phage(40.0%)

integrase,transposase,tail,protease

attL 4752510:4752525|attR 4773395:4773410

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012890893.1\|4733265_4734474_+\|tail	phage tail sheath family protein	A0A191SAV9	Nostoc_phage	6.7e-17	31.7
WP_012890894.1\|4734882_4735320_-	hypothetical protein	NA	NA	NA	NA
WP_012890895.1\|4735360_4737997_-	multicopper oxidase domain-containing protein	NA	NA	NA	NA
WP_012890896.1\|4737993_4738293_-	hypothetical protein	NA	NA	NA	NA
WP_012890897.1\|4738950_4739361_+	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_148269631.1\|4739347_4740676_-	TIGR04053 family radical SAM/SPASM domain-containing protein	NA	NA	NA	NA
WP_052316986.1\|4741349_4741664_-	hypothetical protein	NA	NA	NA	NA
WP_012890899.1\|4742225_4742987_-	glucose 1-dehydrogenase	Q06VL0	Trichoplusia_ni_ascovirus	2.0e-22	33.7
WP_148269632.1\|4743022_4744300_-	MFS transporter	A0A0M3UL24	Mycobacterium_phage	2.4e-49	36.8
WP_012890901.1\|4744478_4745057_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_148269633.1\|4746169_4746499_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_012890903.1\|4746752_4747034_+	hypothetical protein	NA	NA	NA	NA
WP_012890904.1\|4747271_4748114_+\|transposase	IS5-like element ISStro1 family transposase	A0A0M5M147	Mycobacterium_phage	3.6e-78	53.1
WP_012890905.1\|4748132_4748897_-	maleylpyruvate isomerase family mycothiol-dependent enzyme	NA	NA	NA	NA
WP_169369324.1\|4749024_4749423_+\|transposase	Tn3 family transposase	NA	NA	NA	NA
WP_043652455.1\|4749324_4750737_-	PLP-dependent aminotransferase family protein	NA	NA	NA	NA
WP_043652458.1\|4750735_4751983_+	aminotransferase class V-fold PLP-dependent enzyme	NA	NA	NA	NA
WP_043652461.1\|4752011_4753280_+	MFS transporter	NA	NA	NA	NA
4752510:4752525	attL	NA	NA	NA	NA
WP_043652463.1\|4753389_4753581_+	hypothetical protein	NA	NA	NA	NA
WP_043652465.1\|4753609_4754020_+\|transposase	Tn3 family transposase	A0A125RQ78	Bacillus_phage	9.8e-29	44.7
WP_012890909.1\|4754592_4756251_-	hypothetical protein	NA	NA	NA	NA
WP_012890910.1\|4758033_4759386_+	hypothetical protein	NA	NA	NA	NA
WP_012890911.1\|4759652_4760018_+	hypothetical protein	NA	NA	NA	NA
WP_081453168.1\|4760084_4760444_+\|integrase	site-specific integrase	NA	NA	NA	NA
4773395:4773410	attR	NA	NA	NA	NA

DBSCAN-SWA_3

4920638 : 4969378

Bacillus_phage(50.0%)

integrase,transposase

attL 4927352:4927369|attR 4971452:4971469

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012891026.1\|4920638_4921553_+\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_148269149.1\|4921865_4922063_+	hypothetical protein	NA	NA	NA	NA
WP_012891028.1\|4922437_4925029_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_174435259.1\|4925025_4925727_-	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	2.0e-29	36.2
WP_012891030.1\|4926113_4927631_-	alpha/beta fold hydrolase	NA	NA	NA	NA
4927352:4927369	attL	NA	NA	NA	NA
WP_043652537.1\|4927766_4928894_+	sensor histidine kinase	NA	NA	NA	NA
WP_012891032.1\|4928913_4929600_+	response regulator transcription factor	NA	NA	NA	NA
WP_169369332.1\|4929661_4930051_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_052317000.1\|4930302_4930500_-	hypothetical protein	NA	NA	NA	NA
WP_052317001.1\|4930658_4932197_-\|transposase	Tn3 family transposase	A0A125RQ78	Bacillus_phage	5.2e-99	39.2
WP_043652547.1\|4932138_4932636_-	DUF4158 domain-containing protein	A0A125RQ78	Bacillus_phage	1.3e-14	38.5
WP_148269637.1\|4933764_4934991_+\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_012891034.1\|4935705_4936146_-	hypothetical protein	NA	NA	NA	NA
WP_012891035.1\|4936285_4937377_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_012891036.1\|4937509_4938388_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_012891037.1\|4938490_4939924_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_012891038.1\|4940022_4940430_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_012891039.1\|4940479_4941364_+	NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_148269638.1\|4941741_4942281_+	hypothetical protein	NA	NA	NA	NA
WP_012891041.1\|4942466_4943819_+	Dyp-type peroxidase	NA	NA	NA	NA
WP_012891042.1\|4943875_4945030_+	catalase family protein	NA	NA	NA	NA
WP_012891043.1\|4945263_4945941_+	GAP family protein	NA	NA	NA	NA
WP_012891044.1\|4946199_4947366_-	MFS transporter	NA	NA	NA	NA
WP_012891045.1\|4947659_4948259_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_012891046.1\|4948554_4949466_-	sterol desaturase family protein	NA	NA	NA	NA
WP_148269639.1\|4949563_4950343_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_148269150.1\|4950348_4950567_-	hypothetical protein	NA	NA	NA	NA
WP_169369334.1\|4950573_4950717_+	hypothetical protein	NA	NA	NA	NA
WP_148269640.1\|4950774_4951275_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_012891050.1\|4951395_4954665_+	efflux RND transporter permease subunit	NA	NA	NA	NA
WP_012891051.1\|4954839_4956270_+	adenylosuccinate lyase	NA	NA	NA	NA
WP_081453441.1\|4956370_4957057_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_148269151.1\|4957126_4958149_+	DUF4037 domain-containing protein	NA	NA	NA	NA
WP_012891054.1\|4958363_4959125_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_043656299.1\|4959301_4959934_-	alpha-ketoglutarate-dependent dioxygenase AlkB	NA	NA	NA	NA
WP_012891057.1\|4960136_4960391_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012891058.1\|4960652_4961780_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012891059.1\|4961877_4962771_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_043652549.1\|4962945_4963428_+	hypothetical protein	NA	NA	NA	NA
WP_012891061.1\|4963645_4964113_-	hypothetical protein	NA	NA	NA	NA
WP_081453180.1\|4964496_4965000_+	very short patch repair endonuclease	V5UTF4	Oenococcus_phage	1.2e-07	35.7
WP_012891063.1\|4965043_4965529_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_012891064.1\|4965525_4966152_+	methylated-DNA--[protein]-cysteine S-methyltransferase	NA	NA	NA	NA
WP_043652552.1\|4967385_4967937_+	hypothetical protein	NA	NA	NA	NA
WP_012891066.1\|4968027_4968255_+	hypothetical protein	NA	NA	NA	NA
WP_043652555.1\|4968379_4969378_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
4971452:4971469	attR	NA	NA	NA	NA

DBSCAN-SWA_4

5155795 : 5280791

100

Staphylococcus_phage(20.0%)

integrase,transposase

attL 5159252:5159277|attR 5216034:5216059

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012891233.1\|5155795_5156887_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_012891234.1\|5157310_5157628_-	hypothetical protein	NA	NA	NA	NA
WP_043656397.1\|5157806_5158337_+	hypothetical protein	NA	NA	NA	NA
WP_012891236.1\|5158344_5158935_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
5159252:5159277	attL	NA	NA	NA	NA
WP_012891237.1\|5159450_5159885_-	hypothetical protein	NA	NA	NA	NA
WP_012891238.1\|5160118_5160346_-	hypothetical protein	NA	NA	NA	NA
WP_043652629.1\|5160401_5161298_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_043652633.1\|5161820_5162687_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_012891241.1\|5162952_5166099_-	winged helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_043652635.1\|5166239_5167385_+	serine hydrolase	NA	NA	NA	NA
WP_012891243.1\|5167505_5168507_-	WYL domain-containing protein	NA	NA	NA	NA
WP_012891244.1\|5168635_5169322_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_043652649.1\|5171026_5172112_+	helix-turn-helix transcriptional regulator	A0A2H4J145	uncultured_Caudovirales_phage	1.8e-05	45.8
WP_043652655.1\|5172198_5173041_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_081453442.1\|5173149_5174340_+	MFS transporter	NA	NA	NA	NA
WP_012891249.1\|5174603_5175179_+	PadR family transcriptional regulator	NA	NA	NA	NA
WP_012891250.1\|5175175_5175988_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_012891251.1\|5176078_5176669_-	DUF1707 domain-containing protein	NA	NA	NA	NA
WP_012891252.1\|5177967_5179080_+	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_148269162.1\|5180446_5181259_+	hypothetical protein	NA	NA	NA	NA
WP_012891255.1\|5181689_5181986_+	DUF4287 domain-containing protein	NA	NA	NA	NA
WP_052317012.1\|5182701_5183028_-	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_012891256.1\|5183471_5184068_-	cadmium resistance transporter	NA	NA	NA	NA
WP_012891257.1\|5184252_5184645_-	hypothetical protein	NA	NA	NA	NA
WP_148269163.1\|5185675_5186188_+	hypothetical protein	NA	NA	NA	NA
WP_148269164.1\|5186324_5187365_+	hypothetical protein	NA	NA	NA	NA
WP_012891259.1\|5187666_5188110_+	hypothetical protein	NA	NA	NA	NA
WP_148269643.1\|5188106_5189393_-	MFS transporter	NA	NA	NA	NA
WP_174435299.1\|5189778_5190474_+	hypothetical protein	NA	NA	NA	NA
WP_012891262.1\|5190610_5190982_-	DUF4158 domain-containing protein	A0A125RQ78	Bacillus_phage	1.1e-15	39.3
WP_148269165.1\|5191144_5191444_+	hypothetical protein	NA	NA	NA	NA
WP_012891264.1\|5192009_5193557_-	rifampin monooxygenase	NA	NA	NA	NA
WP_012891265.1\|5193696_5194227_-\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	8.6e-17	39.6
WP_043656418.1\|5196851_5197457_-	response regulator transcription factor	NA	NA	NA	NA
WP_169369346.1\|5197493_5198681_-	hypothetical protein	NA	NA	NA	NA
WP_012891268.1\|5198819_5199533_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.2e-31	39.0
WP_012891269.1\|5199529_5200267_+	ABC transporter permease	NA	NA	NA	NA
WP_043652674.1\|5200507_5200717_-	hypothetical protein	NA	NA	NA	NA
WP_012891270.1\|5200958_5201543_+	recombinase family protein	E5FFF9	Burkholderia_phage	1.2e-22	36.1
WP_012891271.1\|5201835_5203029_-	hypothetical protein	NA	NA	NA	NA
WP_012891272.1\|5203474_5204515_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012891273.1\|5204725_5205592_-	universal stress protein	NA	NA	NA	NA
WP_012891274.1\|5205803_5208260_-	cation-transporting P-type ATPase	M1I547	Acanthocystis_turfacea_Chlorella_virus	2.3e-56	28.9
WP_052317015.1\|5208571_5208940_-\|transposase	DDE transposase family protein	NA	NA	NA	NA
WP_012891275.1\|5209287_5209962_+	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_012891276.1\|5210080_5211178_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_012891278.1\|5212815_5213349_+	PadR family transcriptional regulator	NA	NA	NA	NA
WP_012891279.1\|5213345_5214077_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.7e-34	39.5
WP_012891280.1\|5214082_5215873_+	FtsX-like permease family protein	NA	NA	NA	NA
WP_012891281.1\|5216084_5217314_-\|transposase	IS110 family transposase	NA	NA	NA	NA
5216034:5216059	attR	NA	NA	NA	NA
WP_012891282.1\|5217936_5218548_+	hypothetical protein	NA	NA	NA	NA
WP_012891283.1\|5218650_5219862_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_012891284.1\|5220461_5221343_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_081453443.1\|5221329_5222697_-	ATPase	NA	NA	NA	NA
WP_081453444.1\|5223421_5223814_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_012891288.1\|5224043_5225672_+	CocE/NonD family hydrolase	NA	NA	NA	NA
WP_012891289.1\|5225668_5226673_+	reductase	NA	NA	NA	NA
WP_012891290.1\|5226693_5227839_+	FAD-dependent monooxygenase	NA	NA	NA	NA
WP_081453445.1\|5231800_5232571_+\|transposase	transposase family protein	NA	NA	NA	NA
WP_012891293.1\|5232804_5233494_+	FadR family transcriptional regulator	NA	NA	NA	NA
WP_169369348.1\|5233617_5234133_+	hypothetical protein	NA	NA	NA	NA
WP_012891294.1\|5234399_5235194_+	ABC transporter ATP-binding protein	NA	NA	NA	NA
WP_012891295.1\|5235193_5235904_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.9e-11	27.4
WP_012891296.1\|5235915_5236794_+	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_012891297.1\|5236790_5237837_+	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_012891298.1\|5238000_5239245_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_081453194.1\|5239241_5240048_+	creatininase family protein	NA	NA	NA	NA
WP_012891300.1\|5240060_5240939_+	hypothetical protein	NA	NA	NA	NA
WP_012891301.1\|5240938_5241268_+	extradiol ring-cleavage dioxygenase LigAB, LigA subunit	NA	NA	NA	NA
WP_043656439.1\|5241320_5242337_+	amidohydrolase family protein	NA	NA	NA	NA
WP_012891303.1\|5242333_5242945_+	cysteine hydrolase	NA	NA	NA	NA
WP_012891304.1\|5242962_5243811_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_148269166.1\|5243943_5244372_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012890197.1\|5244595_5246353_+\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_148269167.1\|5246461_5247202_+	hypothetical protein	NA	NA	NA	NA
WP_043652687.1\|5247327_5250462_+\|transposase	Tn3 family transposase	Q1MVP5	Enterobacteria_phage	1.7e-192	39.6
WP_012891307.1\|5250831_5251125_-	DUF1330 domain-containing protein	NA	NA	NA	NA
WP_086012369.1\|5251306_5252383_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_086012424.1\|5252412_5252676_-	hypothetical protein	NA	NA	NA	NA
WP_043652693.1\|5253067_5254063_+	recombinase family protein	E5FFF9	Burkholderia_phage	5.5e-17	30.2
WP_012891311.1\|5257031_5263703_+	hypothetical protein	NA	NA	NA	NA
WP_043652695.1\|5264704_5264914_-	hypothetical protein	NA	NA	NA	NA
WP_012891314.1\|5265566_5266250_-	hypothetical protein	NA	NA	NA	NA
WP_148269168.1\|5266246_5266630_-	hypothetical protein	NA	NA	NA	NA
WP_012891316.1\|5267116_5267494_-	hypothetical protein	NA	NA	NA	NA
WP_012891317.1\|5267919_5268498_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_043652699.1\|5268564_5269818_+	MFS transporter	NA	NA	NA	NA
WP_081453195.1\|5270736_5271231_+	NPP1 family protein	NA	NA	NA	NA
WP_148269644.1\|5271291_5271861_+	VOC family protein	NA	NA	NA	NA
WP_043652709.1\|5272745_5273003_-	hypothetical protein	NA	NA	NA	NA
WP_081453196.1\|5273264_5273525_+\|transposase	transposase	NA	NA	NA	NA
WP_043652712.1\|5273543_5274149_-	response regulator transcription factor	NA	NA	NA	NA
WP_012891322.1\|5274148_5275237_-	sensor histidine kinase	NA	NA	NA	NA
WP_012891323.1\|5275244_5275943_-	ABC transporter permease	NA	NA	NA	NA
WP_012891324.1\|5275939_5276653_-	ABC transporter ATP-binding protein	NA	NA	NA	NA
WP_012891325.1\|5276744_5276945_-	hypothetical protein	NA	NA	NA	NA
WP_081453197.1\|5277395_5278202_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_012891326.1\|5279027_5279390_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_012891327.1\|5279489_5280149_+	DsbA family oxidoreductase	NA	NA	NA	NA
WP_043652720.1\|5280164_5280791_+\|transposase	Tn3 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_013595

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information