CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_017340	Staphylococcus aureus 04-02981, complete sequence	11 crisprs	cas3,DEDDh,DinG,csa3,RT,WYL	10	3	8	2

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_017340_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017340_1

187552-187636

Orphan

Consensus_repeat	Method
TTCTACAGGCAATGCAAGTTGGGGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017340_1

>merge|NC_017340|1|187552-187636|CRISPRCasFinder
TTCTACAGGCAATGCAAGTTGGGGTGTGGGCCCCAACAAAGAGAAATTGGATTCCCAATTTCTACAGACAATGCAAGTTGGGGTG

>NC_017340|1|1|187552-187636|CRISPRCasFinder
TTCTACAGGCAATGCAAGTTGGGGTG	TGGGCCCCAACAAAGAGAAATTGGATTCCCAAT
TTCTACAGACAATGCAAGTTGGGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017340.1\|WP_001092004.1\|192677_193037_+\|DUF2294-domain-containing-protein	unknown	unknown	gnl\|CDD\|227896
NC_017340.1\|WP_001237004.1\|183499_183883_-\|YbaN-family-protein	unknown	unknown	gnl\|CDD\|377291
NC_017340.1\|WP_000356963.1\|187697_187901_-\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000826861.1\|194621_195872_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NC_017340.1\|WP_000197961.1\|190655_191417_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NC_017340.1\|WP_000171650.1\|191429_192461_+\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NC_017340.1\|WP_000779504.1\|180617_181880_+\|type-8-capsular-polysaccharide-synthesis-protein-Cap8O	unknown	unknown	gnl\|CDD\|223749
NC_017340.1\|WP_000723436.1\|181956_183102_+\|type-8-capsular-polysaccharide-synthesis-protein-Cap8P	unknown	unknown	gnl\|CDD\|223458
NC_017340.1\|WP_000706135.1\|193210_194236_+\|NAD-dependent-formate-dehydrogenase	unknown	unknown	gnl\|CDD\|181041
NC_017340.1\|WP_000290397.1\|184309_185797_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143435
NC_017340.1\|WP_000605281.1\|196318_203494_+\|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|237108
NC_017340.1\|WP_000825098.1\|179119_179677_+\|type-8-capsular-polysaccharide-synthesis-protein-Cap8M	unknown	unknown	gnl\|CDD\|225059
NC_017340.1\|WP_001013485.1\|186443_187403_+\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
NC_017340.1\|WP_001230679.1\|179676_180564_+\|capsular-polysaccharide-type-5/8-biosynthesis-epimerase-CapN	unknown	unknown	gnl\|CDD\|187543
NC_017340.1\|WP_001291020.1\|177903_179109_+\|type-8-capsular-polysaccharide-synthesis-protein-Cap8L	unknown	unknown	gnl\|CDD\|340825
NC_017340.1\|WP_000239647.1\|176697_177903_+\|capsular-polysaccharide-biosynthesis-protein	unknown	unknown	unknown
NC_017340.1\|WP_000171919.1\|188079_188592_+\|DUF4242-domain-containing-protein	unknown	unknown	gnl\|CDD\|379428
NC_017340.1\|WP_000480603.1\|183166_183493_-\|staphylobilin-forming-heme-oxygenase-IsdI	unknown	unknown	gnl\|CDD\|183968
NC_017340.1\|WP_000826669.1\|189687_190659_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270271
NC_017340.1\|WP_000590855.1\|188933_189674_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041

Protein	Function_ID	Function_description	E-value
NC_017340.1\|WP_001092004.1\|192677_193037_+\|DUF2294-domain-containing-protein	gnl\|CDD\|227896	COG5609, COG5609, Uncharacterized conserved protein [Function unknown].	6.06834e-49
NC_017340.1\|WP_001237004.1\|183499_183883_-\|YbaN-family-protein	gnl\|CDD\|377291	pfam04304, DUF454, Protein of unknown function (DUF454). Predicted membrane protein.	5.80598e-41
NC_017340.1\|WP_000826861.1\|194621_195872_+\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.83774e-72
NC_017340.1\|WP_000197961.1\|190655_191417_+\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	1.22607e-73
NC_017340.1\|WP_000171650.1\|191429_192461_+\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	1.41309e-19
NC_017340.1\|WP_000779504.1\|180617_181880_+\|type-8-capsular-polysaccharide-synthesis-protein-Cap8O	gnl\|CDD\|223749	COG0677, WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NC_017340.1\|WP_000723436.1\|181956_183102_+\|type-8-capsular-polysaccharide-synthesis-protein-Cap8P	gnl\|CDD\|223458	COG0381, WecB, UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane].	0
NC_017340.1\|WP_000706135.1\|193210_194236_+\|NAD-dependent-formate-dehydrogenase	gnl\|CDD\|181041	PRK07574, PRK07574, NAD-dependent formate dehydrogenase.	0
NC_017340.1\|WP_000290397.1\|184309_185797_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143435	cd07117, ALDH_StaphAldA1, Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like. Uncharacterized aldehyde dehydrogenase from Staphylococcus aureus (AldA1, locus SACOL0154) and other similar sequences are present in this CD.	0
NC_017340.1\|WP_000605281.1\|196318_203494_+\|amino-acid-adenylation-domain-containing-protein	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NC_017340.1\|WP_000825098.1\|179119_179677_+\|type-8-capsular-polysaccharide-synthesis-protein-Cap8M	gnl\|CDD\|225059	COG2148, WcaJ, Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane].	3.08096e-87
NC_017340.1\|WP_001013485.1\|186443_187403_+\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	4.11026e-108
NC_017340.1\|WP_001230679.1\|179676_180564_+\|capsular-polysaccharide-type-5/8-biosynthesis-epimerase-CapN	gnl\|CDD\|187543	cd05232, UDP_G4E_4_SDR_e, UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup is comprised of bacterial proteins, and includes the Staphylococcus aureus capsular polysaccharide Cap5N, which may have a role in the synthesis of UDP-N-acetyl-d-fucosamine. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.93098e-117
NC_017340.1\|WP_001291020.1\|177903_179109_+\|type-8-capsular-polysaccharide-synthesis-protein-Cap8L	gnl\|CDD\|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	3.56278e-74
NC_017340.1\|WP_000171919.1\|188079_188592_+\|DUF4242-domain-containing-protein	gnl\|CDD\|379428	pfam14026, DUF4242, Protein of unknown function (DUF4242). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 90 and 170 amino acids in length. There is a single completely conserved residue C that may be functionally important.	2.56603e-26
NC_017340.1\|WP_000480603.1\|183166_183493_-\|staphylobilin-forming-heme-oxygenase-IsdI	gnl\|CDD\|183968	PRK13313, PRK13313, staphylobilin-forming heme oxygenase IsdI.	1.40112e-64
NC_017340.1\|WP_000826669.1\|189687_190659_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270271	cd13553, PBP2_NrtA_CpmA_like, Substrate binding domain of ABC-type nitrate/bicarbonate transporters, a member of the type 2 periplasmic binding fold superfamily. This subfamily includes nitrate (NrtA) and bicarbonate (CmpA) receptors. These domains are found in eubacterial perisplamic-binding proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. These binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.75927e-52
NC_017340.1\|WP_000590855.1\|188933_189674_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	9.30613e-113

>NC_017340.1|WP_001013485.1|186443_187403_+|cation-transporter
MNGKKANTINRYKYFHHVNHQKIQQSSKKTLWASLIITLLFTVIEFVGGLVSNSLALLSDSFHMLSDVLALGLSMLAIYFASKKPTARYTFGYLRFEILVAFLNGLALIVISIWILYEAIVRIIYPQPIESGIMFMIASIGLLVNIILTIILVRSLKQEDNINIQSALWHFMGDLLNSIGVIVAVVLIYFTGWRIIDPIISIVISLIILRGGYKITRNAWLILMESVPQHLDTDQIMADIKNIDGILDVHEFHLWSITTEHYSLSAHVVLDKKYEGDDYQAIDQVSSLLKEKYGIAHSTLQIENLQLNPLDEPYFDKLT
>NC_017340.1|WP_000290397.1|184309_185797_+|aldehyde-dehydrogenase-family-protein
MAVNVRDYIAENYGLFINGEFVKGSSDETIEVTNPATGETLSHITRAKDKDVDHAVKVAQEAFESWSLTSKSERAQMLRDIGDKLMAQKDKIAMIETLNNGKPIRETTAIDIPFAARHFHYFASVIETEEGTVNDIDKDTMSIVRHEPIGVVGAVVAWNFPMLLAAWKIAPAIAAGNTIVIQPSSSTPLSLLEVAKIFQEVLPKGVVNILTGKGSESGNAIFNHDGVDKLSFTGSTDVGYQVAEAAAKHLVPATLELGGKSANIILDDANLDLAVEGIQLGILFNQGEVCSAGSRLLVHEKIYDQLVPRLQEAFSNIKVGDPQDEATQMGSQTGKDQLDKIQSYIDAAKESDAQILAGGHRLTENGLDKGFFFEPTLIAVPDNHHKLAQEEIFGPVLTVIKVKDDQEAIDIANDSEYGLAGGVFSQNITRALNIAKAVRTGRIWINTYNQVPEGAPFGGYKKSGIGRETYKGALSNYQQVKNIYIDTSNALKGLY
>NC_017340.1|WP_001237004.1|183499_183883_-|YbaN-family-protein
MRLILIVIGLIFTALGIAGAVLPLLPTTPFLLVAVFCFARSSDRFYNWLINQKIYKEYVENFYLHRGYTLQQKIKILISLYIVIGFSIYMVDVLAVRVGLIIMVIIQTAVLFTFVKTLPKSNHKIEE
>NC_017340.1|WP_000480603.1|183166_183493_-|staphylobilin-forming-heme-oxygenase-IsdI
MFMAENRLQLQKGSAEETIERFYNRQGIETIEGFQQMFVTKTLNTEDTDEVKILTIWESEDSFNNWLNSDVFKEAHKNVRLKSDDDGQQSPILSNKVFKYDIGYHYQK
>NC_017340.1|WP_000723436.1|181956_183102_+|type-8-capsular-polysaccharide-synthesis-protein-Cap8P
MKKIMVIFGTRPEAIKMAPLVKEIDHNGNFEANIVITAQHRDMLDSVLSIFDIQADHDLNIMQDQQTLADLTANALAKLDSIINEEQPDMILVHGDTTTTFVGSLAAFYHQIPVGHVEAGLRTHQKYSPFPEELNRVMVSNIAELNFAPTVIAAKNLLFENKDKERIFITGNTVIDALSTTVQNDFVSTIINKHKGKKVILLTAHRRENIGEPMHQIFKAVRDLADEYKDVVFIYPMHRNPKVRAIAEKYLSGRNRIELIEPLDAIEFHNFTNQSYLVLTDSGGIQEEAPTFGKPVLVLRNHTERPEGVEAGTSRVIGTDYDNIVRNVKQLIEDDEAYQRMSQANNPYGDGQASRRICEAIEYYFGLRSDKPDEFVPLRHK
>NC_017340.1|WP_000779504.1|180617_181880_+|type-8-capsular-polysaccharide-synthesis-protein-Cap8O
MKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQSGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLVMRALDSILPFLEKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDICLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAGKYVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKHPRVNIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVKSSFEDVSYYNYGNIFNFIDK
>NC_017340.1|WP_001230679.1|179676_180564_+|capsular-polysaccharide-type-5/8-biosynthesis-epimerase-CapN
MRKNILITGVHGYIGNALKDKLIEQGHQVDQINVRNQLWKSTSFKDYDVLIHTAALVHNNSPQARLSDYMQVNMLLTKQLAQKAKAEDVKQFIFMSTMAVYGKEGQVGKSDQIDTQTPMNPTTNYGISKKFAEQALQELISDSFKVAIVRPPMIYGAHCPGNFQRLMQLSKRLPIIPNINNQRSALYIKHLTAFIDQLISLEVTGVYHPQDSFYFDTSSVMYEIRRQSHRKTVLINMPSVLNKYFNKLSVFRKLFGNLTYSNTLYENNNALEVIPGKMSLVIADIMDETTTKDKA
>NC_017340.1|WP_000825098.1|179119_179677_+|type-8-capsular-polysaccharide-synthesis-protein-Cap8M
MKRLFDVVSSIYGLVVLSPILLITALLIKMESPGPAIFKQKRPTINNELFNIYKFRSMKIDTPNVATDLMDSTSYITKTGKVIRKTSIDELPQLLNVLKGEMSIVGPRPALYNQYELIEKRTKANVHTIRPGVTGLAQVMGRDDITDDQKVAYDHYYLTHQSMMLDMYIIYKTIKNIVTSEGVHH
>NC_017340.1|WP_001291020.1|177903_179109_+|type-8-capsular-polysaccharide-synthesis-protein-Cap8L
MSEKKILILCQYFYPEYVSSATLPTQLAEDLIANHINVDVMCGWPYEYSNHKQVSKTEMHRGIRIRRLKYSRFNNKSKVGRIINFFSLFSKFVINIPKMLKYDQILVYSNPPILPLIPDVLHRLLKKKYSFVVYDIAPDNAIKTGATRPGSMIDKLMRYINRHVYKNAENVIVLGTEMKNYLLNHQISKNADNIHVIPNWYDMRQLQDNRIYNDTFKAYREQYDKILLYSGNMGQLQDMETLISFLKLNKDQPQTLTILCGHGKKFADVKTAIEDHRIENVKMFEFLTGTDYADVLKIADVCIASLIKEGVGLGVPSKNYGYLAAKKPLVLIMDKQSDIVQHVEQYDAGIQIDNGDAHAIYNFINTHSSKELHEMGERAHQLFKDKYTREINTMKYYNLLK
>NC_017340.1|WP_000239647.1|176697_177903_+|capsular-polysaccharide-biosynthesis-protein
MVKKVFIMDSVKTIIGTLLIALGLQFLAYPIINQRVGNEAFGSILTIYTIITITSVVLGNTLNNIRLINMNLYKSNHYYWKFVSILLISILIESIALIIVFLYFFNLNTIDIIFLILLNILMCLRIYLNVFFRMTLKYNQILYIALIQFLGLLIGLFLYYLIQNWIVCFITSELFATIYTLVKLRGLTIGEYQSEDNNVVKDYVMLLSTNSLNNLNLYLDRLILLPIIGGTAVTISFLSTFIGKMLATFLYPINNVVLSYISVNESDNIKKQYLKTNLFAIAALCLVMIICYPITLIIVSLLYNIDSSLYSKFIILGNIGVLFNAVSIMIQTLNTKHASITLQANYMTLHTITFIFITILMTIAFGLNGFFWTTLFSNIIKYVILNIIGLKSKFINKKDVD
>NC_017340.1|WP_000356963.1|187697_187901_-|hypothetical-protein
MDKESVVASLARNKKIAVETMAGQRYIIERILHTNDEKHIHILKPKDVVLDVDSIKEIDENHLNDAT
>NC_017340.1|WP_000171919.1|188079_188592_+|DUF4242-domain-containing-protein
MTLFLLEANNLDFASTKEELEAKAASLSTKTIPTLIEVQATENLTHGYFIVEANDEAEAKQFLTEADISIQLVKEVRLVGKDLDEVKNGDAHVDYLVTWNIPEGITMDQYLARKKKNSVHYEEVPEVEFKRTYVCEDMSKCICLYNAPDEEAVRRARKAVDTPIDGIEKL
>NC_017340.1|WP_000590855.1|188933_189674_+|ABC-transporter-ATP-binding-protein
MIKIQQLQHHFGSHKVIHNFNLDISKGEIVTFIGKSGCGKSTLLNVIGGFIHPSSGRVIIDNEIKQQPSPDCLMLFQHHNLLPWKTVNDNIRIGFQQKISDEEINAQLKLVDLEDRGKHFPEQLSGGMKQRVALCRAHVHKPNVILMDEPLGALDAFTRYKLQDQLVQLKHKTQSTIILVTHDIDEAIYLSDRIVLLGEGCNIISQYEITASHPRSRNDSHLLKIRNEIMETFALNHHQVEPEYYL
>NC_017340.1|WP_000826669.1|189687_190659_+|ABC-transporter-substrate-binding-protein
MKRLSIIVIIGIFIITGCDWQRTSKEPSKNAQNQQVIKIGYLPITHSANLMMTKKLLSQYNHPKYKLELVKFNNWPDLMDALNSGRIDGASTLIELAMKSKQKGSNIKAVALGHHEGNVIMGQKGMHLNEFNNGDDYHFGIPHRYSTHYLLLEELRKQLKIKPGHFSYHEMSPAEMPAALSEHRITGYSVAEPFGALGEKLGKGKTLKHGDDVIPDAYCCVLVLRGELLDQHKDVAQAFVQDYKKSGFKMNDRKQSVDIMTHHFKQSRDVLTQSAAWTSYGDLTIKPSGYQEITTLVKQHHLFNPPAYDDFVEPSLYKEASRS
>NC_017340.1|WP_000197961.1|190655_191417_+|ABC-transporter-permease
MTRPTNNKFILPIITFIIFLGIWEMVIIIGHYQPVLLPGPALVGKSIWTFIVTGEIFQHLAISLWRFVAGFVVALLVAIPLGFLLGRNRWLYNAIEPLFQLIRPISPIAWAPFVVLWFGIGSLPAIAIIFIAAFFPIVFNTIKGVRDIEPQYLKIAANLNLTGWSLYRNILFPGAFKQIMAGIHMAVGTSWIFLVSGEMIGAQSGLGFLIVDARNMLNLEDVLAAIFFIGLFGFIIDRFISYIEQFILRRFGE
>NC_017340.1|WP_000171650.1|191429_192461_+|acyl-CoA/acyl-ACP-dehydrogenase
MTLETLIKEQLDPHLVEVDEGTYYPRTFIQQLFVDGYFGEAALRKNAEVIEAVSQSCLTTGFCLWCQLAFSTYLENATQPHLNNDLQQQLLSGEILGATGLSNPMKSFNDLEKLNLEHTYVDGQLVVSGRMPAVSNIQEDHYFGAISKHESSDEFVMFILRANQDGITLVEKTNFLGVNGSATYQITLNQVVVPQSQIITHDAKQFAATIRPQFIAYQIPIRLGSIKSSLELIDAFSNAQNGINQYLEYDVEAFKKRYRQLREEYYAILDDGNLTSHLSELISLKKDIGYLLLDVNQASVVNGGSRAYTPYSPQVRKLKEGFFFAALTPTLRHLGKLEAELKG
>NC_017340.1|WP_001092004.1|192677_193037_+|DUF2294-domain-containing-protein
MNTIDTHTKEQQFSNLVRSYRKEYVGKGPNSIRVSFKDNWAIAHMTGVLSKVESFYLNDKRNESMLHYTRTEKIKQMYKEIDVNEMESLVGAKFVKLFTDIDLNDDEVISIFVFDKSIE
>NC_017340.1|WP_000706135.1|193210_194236_+|NAD-dependent-formate-dehydrogenase
MKIVALFPEAVEGQENQLLNTKKAIGLKTFLEERGHEFIILADNGEDLDKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAGVGSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLILLRNYEEGHRQSVEGEWNLSQVGNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVSSSDAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALASEHLQGYAGDVWYPQPAPADHPWRTMPRNAMTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDIIVASGRIASKSYTAK
>NC_017340.1|WP_000826861.1|194621_195872_+|MFS-transporter
MKRLSTTLKVRLISNFLQLIITTAFIPFIALYLTDMLSQSIVGIYLVGLVVLKFPLSIISGYLIEIFPKKLLVLIYQATMVIMLVFMGVFGSHQLWQIIGFCVAYAIFTIVWGLQFPVMDTLIMDAITEDVEHYIYKISYWMTNLSVAIGALLGGLMYGYSMLLLFLIAACIFLIVLFILYIWLPQDRNQVKQSDDKRHASRYQKLQIMNIFRSYKLVLKDRNYMLLISGFSIIMMGEFSISSYIAIRLKDQFETISIGSYDITGAKMLAILLMINTVVVILLTYSISKVVLKIDFKKALITGLLIYIVGYSGLTYLNQFGLLVVFMIIATVGEIIYSPIVSEQRFKIIPKAKRGTYSAVNALGIHFSETLARLGIVLGVFLTSLQMGLYIFIVLTIGASMLVAGVFGGQKQVNTN
>NC_017340.1|WP_000605281.1|196318_203494_+|amino-acid-adenylation-domain-containing-protein
MIMGNLRFQQEYFRIYKNNTESTTHRNAYWVKLAKNVEATKMMYALSTIVQQHASIRHFFDVTTDDNLTMILHEFLPFIEIKQVPSSSANYDLEAFFKQELSTYHFNDSPLFKVKLFQFADAAYILLDFHVSIFDDSQIDIFLDDLCNAYRGNTVINNTRQHAHINRNDDKDNQDASHIALDSNYFRLENNSDIHIDSYFPIKHPFEQALYQTYLIDDMTSIDMASLAVSVYLANHIMSQQHDVTLGIHVPSHLPNDLHGNIVPLTLTIDAKDVCQRFTTDFNKCVLQNMSQLQCAKSSLSLETIFHCYHHMMSCCNDVIEDVHQIHDAHTSLADIEIFPHQHGFKIIYNSAAYDLLSIETLSDLVRNIYLQITEENGNKRTTVDELNLMTERDIQLYDDINLSLPEIDDAQTVVTLFEQQVEATPNHVAVQFDGVFITYQTLNARANDLAHRLRNQYGVEPNDRVAVIAEKSIEMIIAMIGVLKAGGAYVPIDPNYPSDRQEYILKDATPKVVITYQALYENGKQNINHIDLNKIAWKNIDNLSKCNTLEDHAYVIYTSGTTGNPKGTLIPHRGIVRLVHRNHYVPLNEETTILLSGTIAFDAATFEIYGALLNGGKLIVAKKEQLLNPIAVEQLINENDVNTMWLTSSLFNQIASERIEVLVPLKYLLIGGEVLNAKWVDLLNQKPKHPQIINGYGPTENTTFTTTYNIPNKVPNRIPIGKPILGTHVYIMQGERRCGVGIPGELCTSGFGLAAGYLNQPELTADKFIKDSNINQLMYRSGDIVRLLPDGNIDYLYRKDKQVKIRGFRIELSEVEHALERIQGINKAVVIVQNHDQDQYIVAYYEAMHTLSHNKIKSQLRMTLPEYMIPVNFMHIEQIPITINGKLDKKALPIMDYVDTDAYVAPSTDTEHLLCQIFADILHVNQVGIHDNFFELGGHSLKATLVVNRIEASTGKRLQIGDLLQKPTVFELAQAIAKVQEQNYEVIPEAIVKDDYVLSSAQKRMYLLWKSNHKDTVYNVPFLWRLSSGLNVAQLQQAVQHLIARHEILRTQYIVVDDEVRQRIVADVVADFEEVNTHFTDEQEIMRQFVAPFNLEKPSQIRVRYIRSPLHAYLFIDTHHIINDGMSNIQLMNDLNALYQHKLLLPLKLQYKDYSEWMSHRDMTKHRQYWLSQFKDEVPILSLPTDYVRPNIKTTNGAMMSFTMNQQMRQLLQKYVEKHQITDFMFFMSVVMTLLSRYARKDDVVVGSVMSARMHKGTEQMLGMFANTLVYRGQPSPDKMWTQFLQEVKEMSLEAYEHQEYPFECLVNDLDQSHDASRNPLFDVMLVLQNNETNHAHFGHSKLTHIQPKSVTAKFDLSFIIEEDRDDYTINIEYNTDLYHSETVRHMGNQCMIMIDYILKHQDTLQICDIPNGTEELLNWVNTHVNDRMLNVPGNKSIISYFNEVVSRQGNHVALVMNDLTMTYETLRNYVDAIAHMLLSNGVGNGQRVALFTERSFEMIAAMLATVKVGASYIPIDIDFPNKRQGAILEDAKVTAVMSYGVEIETTLPVIQLENAKGFVESKENEQYDDLHGNQLENTAMLDNEMYAIYTSGTTGMPKGVAIRQRNLLNLVHAWSTELQLGDNEVFLQHANIVFDASVMEIYCCLLNGHTLVIPDREERVNPEQLQQLINKHRVTVASIPLQMCSIMEDFYIEKLITGGATSTASFVKYIEKHCGTYFNAYGPSESTVITSYWSHHCGDLIPETIPIGKPLSNIQVYIMSDGLLCGIGMPGELCIAGDSLAIGYINRPELMADKWQNNPFGKGKLYHSGDLARYTSDGQIEFLGRIDKQVKVNGYRIELDEIENVILAIRGISDCVVTVSHFDTHDILNAYYVGEQQVEQDLKQYLNDQLPKYMIPKTITHIDCMPLTTNDKVDTTRLPNPSPIQQSNKVYSEPSNEIEQTFVDVFGEVLKQNDVGVDDDFFELGGNSLEAMLVVSHLKRFGHHISMQTLYQYKTVRQIVNYMYQNQQSLVALPDNLSELQKIVMSRYNLGILEDSLSHRPLGNTLLTGATGFLGAYLIEALQGYSHRIYCFIRADNEEIAWYKLMTNLNDYFSEETVEMMLSNIEVIVGDFECMDDVVLPENMDTIIHAGARTDHFGDDDEFEKVNVQGTVDVIRLAQQHHARLIYVSTISVGTYFDIDTEDVTFSEADVYKGQLLTSPYTRSKFYSELKVLEAVNNGLDGRIVRVGNLTSPYNGRWHMRNIKTNRFSMVMNDLLQLDCIGVSMAEMPVDFSFVDTTARQIVALAQVNTPQIIYHVLSPNKMPVKSLLECVKRKEIELVSDESFNEILQKQDMYETIGLTSVDREQQLAMIDTTLTLKIMNHISEKWPTITNNWLYHWAQYIKTIFNK

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Crispr_ID: NC_017340_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017340_2

425818-425919

Orphan

Consensus_repeat	Method
TTATGAATTGAGTATTAAATTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017340_2

>merge|NC_017340|2|425818-425919|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTGAAAGTAAATTACAGTTCTATAGGTTTATAAAAAATCAGTTTTTAAATCAAAGCTATATATGAATTGAGTATTAAATTTG

>NC_017340|2|2|425818-425919|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTG	AAAGTAAATTACAGTTCTATAGGTTTATAAAAAATCAGTTTTTAAATCAAAGCTAT
ATATGAATTGAGTATTAAATTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017340.1\|WP_000956137.1\|425935_426892_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NC_017340.1\|WP_000466748.1\|417087_417339_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NC_017340.1\|WP_000551643.1\|433763_434300_-\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000052781.1\|421673_422243_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|211789
NC_017340.1\|WP_000421411.1\|428734_429313_+\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181705
NC_017340.1\|WP_000394698.1\|427009_427672_-\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000159787.1\|435794_436067_-\|transposase	unknown	unknown	gnl\|CDD\|225511
NC_017340.1\|WP_000930514.1\|420134_421658_-\|alkyl-hydroperoxide-reductase-subunit-F	unknown	unknown	gnl\|CDD\|237942
NC_017340.1\|WP_000424963.1\|432109_433651_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NC_017340.1\|WP_000763767.1\|427814_428222_-\|general-stress-protein	unknown	unknown	gnl\|CDD\|378584
NC_017340.1\|WP_001792089.1\|425042_425141_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000158375.1\|417764_418346_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NC_017340.1\|WP_000868256.1\|418411_418795_-\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000041880.1\|434691_435396_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NC_017340.1\|WP_000746679.1\|419064_419691_-\|NDxxF-motif-lipoprotein	unknown	unknown	gnl\|CDD\|380196
NC_017340.1\|WP_000264071.1\|430618_432085_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NC_017340.1\|WP_000211677.1\|417377_417587_-\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_001287099.1\|422734_423490_+\|NADPH-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|380322
NC_017340.1\|WP_000991018.1\|423569_424958_-\|L-cystine-transporter	unknown	unknown	gnl\|CDD\|224736
NC_017340.1\|WP_000793023.1\|429312_430581_+\|purine-permease	unknown	unknown	gnl\|CDD\|274468

Protein	Function_ID	Function_description	E-value
NC_017340.1\|WP_000956137.1\|425935_426892_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00265416
NC_017340.1\|WP_000466748.1\|417087_417339_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	1.58864e-09
NC_017340.1\|WP_000052781.1\|421673_422243_-\|peroxiredoxin	gnl\|CDD\|211789	TIGR03137, AhpC, peroxiredoxin. This peroxiredoxin (AhpC, alkylhydroperoxide reductase subunit C) is one subunit of a two-subunit complex with subunit F(TIGR03140). Usually these are found as an apparent operon. The gene has been characterized in Bacteroides fragilis, where it is important in oxidative stress defense. This gene contains two invariant cysteine residues, one near the N-terminus and one near the C-terminus, each followed immediately by a proline residue. [Cellular processes, Detoxification, Cellular processes, Adaptations to atypical conditions].	1.50623e-124
NC_017340.1\|WP_000041880.1\|434691_435396_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	5.38181e-08
NC_017340.1\|WP_000421411.1\|428734_429313_+\|xanthine-phosphoribosyltransferase	gnl\|CDD\|181705	PRK09219, PRK09219, xanthine phosphoribosyltransferase; Validated.	1.38815e-118
NC_017340.1\|WP_000930514.1\|420134_421658_-\|alkyl-hydroperoxide-reductase-subunit-F	gnl\|CDD\|237942	PRK15317, PRK15317, alkyl hydroperoxide reductase subunit F; Provisional.	0
NC_017340.1\|WP_001287099.1\|422734_423490_+\|NADPH-dependent-oxidoreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	4.50551e-88
NC_017340.1\|WP_000424963.1\|432109_433651_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NC_017340.1\|WP_000763767.1\|427814_428222_-\|general-stress-protein	gnl\|CDD\|378584	pfam11181, YflT, Heat induced stress protein YflT. YflT is a heat induced protein.	2.17298e-12
NC_017340.1\|WP_000158375.1\|417764_418346_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	2.4566e-49
NC_017340.1\|WP_000159787.1\|435794_436067_-\|transposase	gnl\|CDD\|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	9.23077e-11
NC_017340.1\|WP_000793023.1\|429312_430581_+\|purine-permease	gnl\|CDD\|274468	TIGR03173, pbuX, xanthine permease. All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.	5.74823e-170
NC_017340.1\|WP_000264071.1\|430618_432085_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NC_017340.1\|WP_000746679.1\|419064_419691_-\|NDxxF-motif-lipoprotein	gnl\|CDD\|380196	NF033193, lipo_NDxxF, NDxxF motif lipoprotein. Members of this family are lipoproteins, about 200 amino acids long in precursor form, found in Staphylococcus aureus, Bacillus cereus, and various other Firmicutes. The protein family is named for one of its several highly conserved motifs.	1.15385e-71
NC_017340.1\|WP_000991018.1\|423569_424958_-\|L-cystine-transporter	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	0

>NC_017340.1|WP_001792089.1|425042_425141_+|hypothetical-protein
MQLNVNMMKFDRWHKGICKQIVLNLVEKGEKG
>NC_017340.1|WP_000991018.1|423569_424958_-|L-cystine-transporter
MNAFLTLINIIVLVIFIVILHMMARKHISFAKRVFTALGIGIVFGVLLHLVYGTHSNVITSTSDWFNIVGQGYVALLQMIVMPLIFISIVAAFTKIQIGEKFAKIGSLIFIFLIGTVTIAAIVGVVYALVFGLDASTINLGNAEQARGSEIAKQAKDLTAHTLPQQILELLPKNPFLDFTGQRATSTIAVVIFASFIGFAYLRVARKQPDHGELLKRAIDAIYSLVMAIVTFVLRLTPYGVLAIMANTLSTSDFGAIWTLGKFLIASYAALITMYIIHLIILSLLGISPIRYVKKTLEVLIFAFTSRSSAGALPLNVQTQTRRLGVPEGIANFAATFGLSIGQNGCAGIYPAMLAIMVAPVANVEIDLQFIVTLIAVVIISSFGVAGVGGGATFASILVLSTLNLPVALAGVLISVEPLIDMGRTALNVNDSMLAGTGTAKLTKHWDKDTFESNDNAALTSH
>NC_017340.1|WP_001287099.1|422734_423490_+|NADPH-dependent-oxidoreductase
MSDYVYNLVKKHHSVRKFKNKPLSEDVVKKLVEAGQSASTSSFLQAYSIIGIDDEKIKENLREVSGQPYVVENGYLFVFVIDYYRHHLVDQHAETDMENAYGSTEGLLVGAIDAALVAENIAVTAEDMGYGIVFLGSLRNDVERVREILDLPDYVFPVFGMAVGEPADDENGAAKPRLPFDHVFHHNKYHADKETQYAQMADYDQTISEYYDQRTNGNRKETWSQQIEMFLGNKARLDMLEQLQKSGLIQR
>NC_017340.1|WP_000052781.1|421673_422243_-|peroxiredoxin
MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLAQRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQPGLDLVGKI
>NC_017340.1|WP_000930514.1|420134_421658_-|alkyl-hydroperoxide-reductase-subunit-F
MLNADLKQQLKQLLELMEGNVEFVASLGSDEKSKELKELLTEISDMSPRLSLSEKSLKRTPSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKNLEGSFHFETFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNGRMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGGQVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENGAVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEAAIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYEDMSTGEEHLLNLDGIFVQIGLLPNTSWLKDAVELNERGEIVIDRNNNTNVPGIFAAGDVTDQKNKQIIISMGAGANAALNAFDYIIRN
>NC_017340.1|WP_000746679.1|419064_419691_-|NDxxF-motif-lipoprotein
MKKRLLLSTFLASALILTGCASDQSDNEDHHTSTGIHAPKSAKKLETKDIFNSDKKNSDISDAEMKQAIEKYLSVNSDILDNKYIMQHKLDKQIDSQTKVTEKQAETLSHLSNLAVKNDLHFKKFVTENNIPKEYKKPVELMMNYFKALNSTIANVDEDIEKLSYQPQNKINVVDVPTKYAGDVNKKQQDKIKDFLKSKGIKSDVIDK
>NC_017340.1|WP_000868256.1|418411_418795_-|hypothetical-protein
MKVRITFIILAILSTIVCLFLAAMHPTGPNTVTFEQPYLFTLNIILMVLVALPSLVLAIYDYMSFRISSAILQFLGAISWFFLSLILSLTQFTPFTLASFITSIILFISAIITLAIGGKSVDKNDSH
>NC_017340.1|WP_000158375.1|417764_418346_+|histidine-phosphatase-family-protein
MTIYLVRHGESKSNYDNKHFRSYFCGQLDVPLTDTGTKSADDLCDYFKEKQIKHVYVSDLLRTQQTFEHIFPYDIASTTTPLLRERSLGVFEGEYKDEISANPKYEKYFNDPNFKDFRHSFSQKAPEGESYEDVYQRVEHFMNHVVNEDTQKDDIVIVAHQVVIRCLMVYFNKVSREEAVDLKVENCKPYIIE
>NC_017340.1|WP_000211677.1|417377_417587_-|hypothetical-protein
MTTQSFIFMNIILLDGATQRHPFFICQILAFLFPKFPHINLLLFYPILSTFSNIIIHIDHFHANKKDDN
>NC_017340.1|WP_000466748.1|417087_417339_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MFGFIGMLIVGGLIGWAAGAIMGKDIPGGILGNIIAGIIGSWVGGKLFGQWGPELGSIYILPALIGSIILIAIVTLILRAMRK
>NC_017340.1|WP_000956137.1|425935_426892_-|hypothetical-protein
MLTKEFAQRVELSEKQVRKIVQHLEERGYQLSKTEYRGREATDFKEEDIELFKDIADKVKQTNSYDLAFDELEKEKDFLQVIVKNDDKNLPTNQNVAQLVEDLRLEIQKMREERHLLGQMMNQVHQQQQELKELQNQLTSKIDSNSESLKAIQTSQEAIQEAQASQAKVLAESTNKVEKNAVTEDKADSKDSKVAGVNTSTDAKTDTKAENAGDGTATKVDKEDQISATEAIEKASVEQSKNENAAETSNKEATVDADAQHDAEQQVAEAHAEASKQATSNDSLEAKAENDSTASQSEMSEPKPQEEKKGFFARLFNL
>NC_017340.1|WP_000394698.1|427009_427672_-|hypothetical-protein
MEFKTIQSVKDPHYNEALKLYDTKLNLSLTEDKRIIKRSLENNKTENDYVFIVGLENDVVVSLATAHYEATTNSAFLIYLFAKDLPNHDELMTQTLHQIEHELNLLSNLVHSRSINFLMMEVPKEPADLTQDNGLIIEHRRQFLYEHQFERQTEIDYIHPTNDGHTKKVDLFLKKNIKLTKDIYGTSVKSNYILKYVFANGIAREIIYALLEEMDLRKPF
>NC_017340.1|WP_000763767.1|427814_428222_-|general-stress-protein
MADITVVNDTGELYNVINQKKSEGYLESELTIISKSKLHLNDLHDSEISLISTSGTFSDRMTKLLTGEDGEHAVLSRYNLAPDELEKYKQLILDDKMLVVAVRDKSSHKEVQEHNSAYEEIDITHFAEASKGPKA
>NC_017340.1|WP_000421411.1|428734_429313_+|xanthine-phosphoribosyltransferase
MELLGQKVKEDGVVIDEKILKVDGFLNHQIDAKLMNEVGRTFYEQFKDKGITKILTIEASGIAPAIMAALHFDVPCLFAKKAKPSTLTDGYYETSIHSFTKNKTSTVIVSKEFLSEEDTVLIIDDFLANGDASLGLYDIAQQANAKTAGIGIVVEKSFQNGHQRLEEAGLTVSSLCKVASLEGNKVTLVVEE
>NC_017340.1|WP_000793023.1|429312_430581_+|purine-permease
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILIGQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTLIIILVLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIESTGVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLLICGCIPKLGALANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAISAIILNFFFNGIKYKQTEENVK
>NC_017340.1|WP_000264071.1|430618_432085_+|IMP-dehydrogenase
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQENLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQITKESPNYSF
>NC_017340.1|WP_000424963.1|432109_433651_+|glutamine-hydrolyzing-GMP-synthase
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHKAIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEVLQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
>NC_017340.1|WP_000551643.1|433763_434300_-|hypothetical-protein
MHNKNEFNKKLKDFIGSDKRMALVKGYINEYKLTTVLRALNNSDYTKGTIHTRSIGNLKQIVDNRIIPKNITQNKIFKLSNLTLEVNLYERNTIYHGDFAIYYPVESALIIETDTPRLINHINNNPVQKIFIITTNDWSFNTLELEKIVDETIIYDLKQEDPKQYEILYKNKHGKLPY
>NC_017340.1|WP_000041880.1|434691_435396_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MSKNINQANSKLNTSNKKLKQAYSKSDSKNMKVIYMPHWLEFYSIAIHSDVTSNKKRYYKSFSRGTVVYVKLGSNIGSEFSGNHFCVILDNKDNKGKETVTIVPLSSKGNKNYLKLNESVLNLTATDLKKQIIDISSKVQALTQKYRDIDIKLSTEDKKLLSNLNQKANELYRVIGVYSKHKGKDTYVNISAITTISKRRISKINDSDPTGTIIISEDDMNEIEKQLKIKFFSN
>NC_017340.1|WP_000159787.1|435794_436067_-|transposase
MTKERRTFSSEFKLQMVRLYKNGKLKNEIIRKYDLKPSIISNSIKQHQNTGPFNHQDNLKSDEKELIKLRKEVQHLKMEHDVLKQILKLI

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Crispr_ID: NC_017340_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017340_3

774801-774883

Orphan

Consensus_repeat	Method
CCAATTTCTACAGACAATGCAAGTTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017340_3

>merge|NC_017340|3|774801-774883|CRISPRCasFinder
CCAATTTCTACAGACAATGCAAGTTGGCGGGGCCCCAACATAGAGAAATTGGAACGCCAATTTCTACAGACAATGCAAGTTGG

>NC_017340|3|3|774801-774883|CRISPRCasFinder
CCAATTTCTACAGACAATGCAAGTTGG	CGGGGCCCCAACATAGAGAAATTGGAACG
CCAATTTCTACAGACAATGCAAGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017340.1\|WP_000663030.1\|772712_773771_+\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|235106
NC_017340.1\|WP_000930014.1\|778563_779064_-\|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	unknown	unknown	gnl\|CDD\|223851
NC_017340.1\|WP_001068501.1\|779083_779950_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NC_017340.1\|WP_000197262.1\|774109_774652_+\|5'-3'-deoxyribonucleotidase	unknown	unknown	gnl\|CDD\|226895
NC_017340.1\|WP_000193751.1\|776717_778223_-\|peptide-MFS-transporter	unknown	unknown	gnl\|CDD\|225646
NC_017340.1\|WP_031760357.1\|776538_776640_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_001797134.1\|761414_761621_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000098285.1\|763880_765821_+\|polyglycerol-phosphate-lipoteichoic-acid-synthase-LtaS	unknown	unknown	gnl\|CDD\|224287
NC_017340.1\|WP_000429006.1\|775530_776448_-\|diacylglycerol-kinase-family-lipid-kinase	unknown	unknown	gnl\|CDD\|224513
NC_017340.1\|WP_000708690.1\|761708_762419_+\|allophanate-hydrolase-subunit-1	unknown	unknown	gnl\|CDD\|224960
NC_017340.1\|WP_000983677.1\|767985_769767_+\|DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|273594
NC_017340.1\|WP_000022323.1\|762402_763407_+\|biotin-dependent-carboxyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224895
NC_017340.1\|WP_000180991.1\|770958_772473_+\|ABC-transporter-permease/substrate-binding-protein	unknown	unknown	gnl\|CDD\|270328
NC_017340.1\|WP_000562498.1\|783334_784306_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|275027
NC_017340.1\|WP_000876318.1\|784680_785652_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226965
NC_017340.1\|WP_000692521.1\|780750_781149_+\|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI	unknown	unknown	gnl\|CDD\|224694
NC_017340.1\|WP_000589248.1\|769988_770966_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224050
NC_017340.1\|WP_000525106.1\|766090_767974_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_017340.1\|WP_000499195.1\|784486_784642_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000855514.1\|781111_783217_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|236069

Protein	Function_ID	Function_description	E-value
NC_017340.1\|WP_000663030.1\|772712_773771_+\|histidinol-phosphate-transaminase	gnl\|CDD\|235106	PRK03158, PRK03158, histidinol-phosphate aminotransferase; Provisional.	0
NC_017340.1\|WP_000930014.1\|778563_779064_-\|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	gnl\|CDD\|223851	COG0780, COG0780, Enzyme related to GTP cyclohydrolase I [General function prediction only].	7.91282e-79
NC_017340.1\|WP_001068501.1\|779083_779950_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	3.04233e-10
NC_017340.1\|WP_000197262.1\|774109_774652_+\|5'-3'-deoxyribonucleotidase	gnl\|CDD\|226895	COG4502, COG4502, 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism].	3.14113e-108
NC_017340.1\|WP_000193751.1\|776717_778223_-\|peptide-MFS-transporter	gnl\|CDD\|225646	COG3104, PTR2, Dipeptide/tripeptide permease [Amino acid transport and metabolism].	1.22605e-172
NC_017340.1\|WP_000855514.1\|781111_783217_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|236069	PRK07632, PRK07632, ribonucleotide-diphosphate reductase subunit alpha; Validated.	0
NC_017340.1\|WP_000098285.1\|763880_765821_+\|polyglycerol-phosphate-lipoteichoic-acid-synthase-LtaS	gnl\|CDD\|224287	COG1368, MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane].	0
NC_017340.1\|WP_000429006.1\|775530_776448_-\|diacylglycerol-kinase-family-lipid-kinase	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	7.55646e-79
NC_017340.1\|WP_000708690.1\|761708_762419_+\|allophanate-hydrolase-subunit-1	gnl\|CDD\|224960	COG2049, DUR1, Allophanate hydrolase subunit 1 [Amino acid transport and metabolism].	1.34598e-94
NC_017340.1\|WP_000983677.1\|767985_769767_+\|DNA-helicase-RecQ	gnl\|CDD\|273594	TIGR01389, recQ, ATP-dependent DNA helicase RecQ. The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_017340.1\|WP_000022323.1\|762402_763407_+\|biotin-dependent-carboxyltransferase-family-protein	gnl\|CDD\|224895	COG1984, DUR1, Allophanate hydrolase subunit 2 [Amino acid transport and metabolism].	1.25641e-144
NC_017340.1\|WP_000180991.1\|770958_772473_+\|ABC-transporter-permease/substrate-binding-protein	gnl\|CDD\|270328	cd13610, PBP2_ChoS, Substrate-binding domain ChoS of an osmoregulated ABC-type transporter and related proteins; type 2 periplasmic-binding protein fold. Osmoprotectant binding lipoprotein ChoS of Lactococcus lactis is predicted to be involved in uptake of compatible solutes such as choline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. ChoS belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.03165e-152
NC_017340.1\|WP_000562498.1\|783334_784306_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	gnl\|CDD\|275027	TIGR04171, ribonucleotide-diphosphate_reductase_subunit_beta, ribonucleoside-diphosphate reductase, class 1b, beta subunit. Members of this family are NrdF, the beta subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	2.30551e-164
NC_017340.1\|WP_000876318.1\|784680_785652_+\|ABC-transporter-permease	gnl\|CDD\|226965	COG4606, CeuB, ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism].	1.32603e-150
NC_017340.1\|WP_000692521.1\|780750_781149_+\|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI	gnl\|CDD\|224694	COG1780, NrdI, Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism].	5.52807e-56
NC_017340.1\|WP_000589248.1\|769988_770966_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	1.28246e-155
NC_017340.1\|WP_000525106.1\|766090_767974_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0

>NC_017340.1|WP_000197262.1|774109_774652_+|5'-3'-deoxyribonucleotidase
MTRKSIAIDMDEVLADTLGEIIDAVNFRADLGIKMEALNGQKLKHVIPEHDGLITEVLREPGFFRHLKVMPHAQEVVKKLTEHYDVYIATAAMDVPTSFSDKYEWLLEFFPFLDPQHFVFCGRKNIVKADYLIDDNPRQLEIFTGTPIMFTAVHNINDDRFERVNSWKDVEQYFLDNIEK
>NC_017340.1|WP_000663030.1|772712_773771_+|histidinol-phosphate-transaminase
MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYYPETGSPTLKAAISKHLNVDQSRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHNAIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPNNPTGTYFNHESLDSFLSQVPPHVPVIIDEAYFEFVTAEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAIEKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVTHKNSVERERFYQLPQSEYFLPSQTNFIFVKTKRVNELYEALLNVGCITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE
>NC_017340.1|WP_000180991.1|770958_772473_+|ABC-transporter-permease/substrate-binding-protein
MTNFFDILSERKGQLFSTMIEHIQISFIALLIATAIAVPLGILLTKTKTISEIVMNIAAILQTIPSLALLGLMIPLFGIGRVPAIIALVVYALLPILRNTYTGIKEVDPSLIEAAKGIGMKPFRRLTKVELPIAMPVIMAGVRTAMVLIIGTATLAALIGAGGLGDLILLGIDRNNASLILLGAIPAALLAIIFDLILRFMAKLSYKKLLMTLGVIVMIIILAIAIPMFAQKGDKITLAGKLGSEPSIITNMYKILIEEETKNTVEVKDGMGKTAFLFNALKSDDIDGYLEFTGTVLGELTKEPLKSKEEKKVYEQAKQSLEKKYQMTMLKPMKYNNTYALAVKRDFAKQHNIRTIGDLNKVKDQLKPGFTLEFNDRPDGYKAVQKAYNLNLDNIRTMEPKLRYQAINKGNINLIDAYSTDAELKQYDMVVLKDDKHVFPPYQGAPLFKESFLKKHPEIKKPLNKLENKISDEDMQMMNYKVTVKNEDPYTVAKDYLKAKGLIK
>NC_017340.1|WP_000589248.1|769988_770966_+|ABC-transporter-ATP-binding-protein
MIKFKNVTKRYGKHVAVDNISFNINEGEFFVLIGPSGCGKTTTLKMINRLIHLSEGYIYFKDKPISDYPVYEMRWDIGYVLQQIALFPHMTIKENIAQVPQMKKWKEKDIDKRVDELLDMVGLEPEKYKNRKPDELSGGQRQRVGVIRALAADPPVILMDEPFSALDPISREKLQDDLIELQTKIKKTIIFVTHDIQEAMKLGDKICLLNEGHIEQIDTPEGFKNNPQSEFVKQFMGSHLEDDAPCVEENAIIRDLDIMKPIDEVTSMSAYPIVYDNQPIEVLYQHLSESERVIVMQEDSVGQYVIDRKDIFKYLSQKKEVAQHD
>NC_017340.1|WP_000983677.1|767985_769767_+|DNA-helicase-RecQ
MMQQTLSHYFGYETFRPGQEEIISKVLDHRNVLGVLPTGGGKSICYQVPGLLLGGTTIVISPLISLMKDQVDQLKAMGIQAAFLNSSLTQKEQQRIEKALSNGEIQFLYVAPERFENRYFLNMLQRIKIHLVAFDEAHCISKWGHDFRPSYQNVISKVFTLPQDFTIIALTATATVEVQQDIREKLNIAQTDQIKTSTKRRNLIFKVNPTYQRQKFILDYIKTHDEDAGIIYCSTRKQVEELQEALESQKIESVIYHAGLSNKEREEAQNDFLFDRVKVVVATNAFGMGIDKSNVRFVIHYNMPGDLESYYQEAGRAGRDGLKSECILLFSERDINLHEYFITVSQADDDYKDKMGEKLTKMIQYTKTKKCLEATIVHYFEPNEKLEECEQCSNCVQQDKSYNMTQEAKMIISCIARMKQQESYSVIIQVLRGESTDYIKYKGYDQISTHGLMKGYTTSELSHLIDELRFKGFLNENDEILMCDTSIKKLLSNEVEVFTTPFKQKATEKVFINTVEGVDRVLFSQLVEVRKKLSDKLTIAPVSIFSDYTLEEFAKRKPASKQDMINIDGVGSYKLKHYCPAFLETIQNYKAKV
>NC_017340.1|WP_000525106.1|766090_767974_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MGMEAYKIEHLNKSYADKTIFDNLDLSISEGEKIGLVGINGTGKSTLLKVIGGIDDDFTANVMHPNQYRIRYSSQKQDLNEDMTVFDAVLSSDTTTLRIIKQYEQAVQAYADDQSDKLFKRMIDAQDAMDQHDAWDYNAEIKTILSKLGIHDTTKYIKELSGGQQKRVVLAKTLIEQPDLLLLDEPTNHLDFESISWLINYVKQYPHTVLFVTHDRYFLNEVSTRIIELNRGKLASYPGNYESYIEMRAEREVTLQKQQQKQRALYKEELAWMRAGAKARTTKQQARINRFNDLENEVNQQYKDDKGELNLAYSRLGKQVFELEDLSKAINDKVLFEHLTEIIQKGERIGVVGPNGAGKTTLLNILSGEDQQFEGKLKTGQTVKVAYFKQTDETLDRDIRMIDYLREESEVAKEKDGTSVSITQLLERFLFPSATHGKKVYKLSGGEQKRLYLLRLLVHQPNVLLLDEPTNDLDTETLTILEDYIHTFGGTVITVSHDRYFLNKVAQSYWFIHDGQMEKIIGTFEDYESYKKSLDKNKSTLKQQSKSYTTVRKKNGLSYKEKLEYEQLMKRIEQAEVRMEEIDVLMIEASADYGKIKELNEEKEQLEIQYDLDITRWSELEEIKEQQ
>NC_017340.1|WP_000098285.1|763880_765821_+|polyglycerol-phosphate-lipoteichoic-acid-synthase-LtaS
MSSQKKKISLFAFFLLTVITITLKTYFSYYVDFSLGVKGLVQNLILLMNPYSLVALVLSVFLFFKGKKAFWFMFIGGFLLTFLLYANVVYFRFFSDFLTFSTLNQVGNVESMGGAVSASFKWYDFVYFIDTLVYLFILIFKTKWLDTKAFSKKFVPVVMAASVALFFLNLAFAETDRPELLTRTFDHKYLVKYLGPYNFTVYDGVKTIENNQQKALASEDDLTKVLNYTKQRQTEPNPEYYGVAKKKNIIKIHLESFQTFLINKKVNGKEVTPFLNKLSSGKEQFTYFPNFFHQTGQGKTSDSEFTMDNSLYGLPQGSAFSLKGDNTYQSLPAILDQKQGYKSDVMHGDYKTFWNRDQVYKHFGIDKFYDATYYDMSDKNVVNLGLKDKIFFKDSANYQAKMKSPFYSHLITLTNHYPFTLDEKDATIEKSNTGDATVDGYIQTARYLDEALEEYINDLKKKGLYDNSVIMIYGDHYGISENHNNAMEKLLGEKITPAKFTDLNRTGFWIKIPGKSGGINNEYAGQVDVMPTILHLAGIDTKNYLMFGTDLFSKGHNQVVPFRNGDFITKDYKYVNGKIYSNKNNELITTQPADFEKNKKQVEKDLEMSDNVLNGDLFRFYKNPDFKKVNPSKYKYETGPKANSKK
>NC_017340.1|WP_000022323.1|762402_763407_+|biotin-dependent-carboxyltransferase-family-protein
MSIIIEKSGLFSSFQDFGRRGYEHDGVIPCGALDTLAHEIANRLVANDKNEATLEMTNKMATIRFTEPTLIALAGGNVKAYTEHMTISPYKLYLLDKGDVLKFRETSYTSRVYLAVGGGFELDAWLGSNSTDFNVKIGGFKGRTLQDGDEIKLKRDYTARHHKLFENLAHTKQTDWGIDGYALSFNYMSDVFHVVKNKGTEDFKEDAIQRFVKHDYKVTSKANRMGMMLEGEKIKAFYEDMPPYQTVKKGTIQIKRDGTPIILLNDHYTLGSYPQIGTIASYHLTKLAQKPQGSRLKFQFIDILTAEKNLVKYSNWLNQLFHGIEYRMQLEMMK
>NC_017340.1|WP_000708690.1|761708_762419_+|allophanate-hydrolase-subunit-1
MKIYSQGDQAIVVAIEKEVSKSLTEDLLTLRSYLIEQNYPFIIEIVPSESDMMIVYDARDMIKHHNIQSPFLYMKALIESIHLNIKHDFNQQDLIEIPIVYGSKYGPDIESLLKHYKIKLETFIELHSKTQYFVSMMGYSPGFPYLTGLNKKLYINHTSKQKKFIPAGSVVLEGKKCGIVTTDTINDWLVIGYTPLSLFNPKESDFARLKLGDNIKFRPINENELEVGAFKDVNHN
>NC_017340.1|WP_001797134.1|761414_761621_+|hypothetical-protein
MIIVYIVLLLILVYVNYRLVNRLLSENRIYVVRLIVTITTVISFILVYALIHELMPFVVRAMDLMYHQ
>NC_017340.1|WP_000429006.1|775530_776448_-|diacylglycerol-kinase-family-lipid-kinase
MENKYTHGVLFYHEHSGLKNINQGIGEVTTALSSICKHLSIQLSENEGDIIKYCQEIKTKNYAKDVDILFILGGDGTVNELINGVMSHDLQLPIGILPGGTFNDFTKTLNIAPNHKQASEQMISAQVGTYDVIKINNQYALNFVGLGLIVQNAENVQDGSKDIFGKLSYIGSTVKTLLNPTQFNYQLSIDDKTYSGETTMILTANGPFIGGSRIPLTDLSPQDGELNTFIFNEQSFSILNDIFKKRDSMNWNEITQGIEHIPGKKISLTTDPAMKVDIDGEISLETPIDIEVIPNAIQLLTVNDL
>NC_017340.1|WP_031760357.1|776538_776640_+|hypothetical-protein
MVITDIDVYRVGRENIVIAVYNEHIKLLFILIS
>NC_017340.1|WP_000193751.1|776717_778223_-|peptide-MFS-transporter
MTQQNSHGNQIQDIPQTGFFGHPRGLGVLFFVEFWERFSYYGMRALLIFYMYFAVTDNGLGIDKTTAMSIMSVYGSLIYMTSIPGGWIADRITGTRGATLLGAVFIIIGHICLSLPFALIGLFTSMFFIIIGSGLMKPNISNIVGRLYPENDRRMDAGFVIFYMSVNMGALLSPIILQHFVNVKNFHGGFLIAAVGMALGLVWYVLFNRKNLGSVGMKPTNPLTPAEKKKYGLIIGSVVLAIVLIIVIGALTNSLSFNLVSNTVLVLGIALPIIYFTLIIRSKDVTDTERSRVKAFIPLFILGMVFWAIQEQGSNVLNIYGIEHSDMKLNLFGWKTNFGEAIFQSINPLFILLLAPIISLLWQKLGTKQPSLPVKFAIGTFLAGASYILIGIVGYASGSSNFSVNWVILSYIICVIGELCLSPTGNSAAVKLAPKAFNAQMMSIWYLTNASAQAINGTLVKLIEPLGQTNYFIFLGVVAIIVTTIVLAFSPLIIKAMKGIR
>NC_017340.1|WP_000930014.1|778563_779064_-|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF
MAHGRQQDELQDITLLGNQDNTYNFDYRPDVLESFDNKHQGRDYFVKFNCPEFTSLCPITGQPDFATIYISYIPNVKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPHYIEVWGKFTPRGGISIDPYTNYGRPNSKYEKMAEHRLMNHDLYPEKIDNR
>NC_017340.1|WP_001068501.1|779083_779950_-|DMT-family-transporter
MNPKVKGIIAILISAIGFSFMSVFFRLAGDLPVFQKSLARNLVAMFIPLFFLYKYHQPMFGRLSSQPLLITRSTLGLIGVLLNIYAIDHMVLSDADSLMKLNPFWTILLSIVFLHEKVRKYQITAMIIAILGMLLIVKPEFSSSMIPSLAGLFSGIFAASAYTCVRALSSREAPYTIVFYFSLFSVIVLIPFTAYTYEPMSQMQILYLLGAGLAAAVGQIGVTLAYSFAAAKDISIFTYASIIFTAILGFVLFGESPDFYATLGYVVIIGASYYMFEKARRDAKIIKK
>NC_017340.1|WP_000692521.1|780750_781149_+|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI
MKIIYFSFTGNVRRFIKRTELENTLEITAENCMEPVHEPFIIVTGTIGFGEVPEPVQSFLEVNHQYIRGVAASGNRNWGLNFAKAGRTISEEYNVPLLMKFELHGKNKDVIEFKNKVGNFNENHGREKVQSY
>NC_017340.1|WP_000855514.1|781111_783217_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha
MKTMEEKKYNHIELNNEVTKRREDGFFSLEKDQEALVAYLEEVKDKTIFFDTEIERLRYLVDNDFYFNVFDIYSEADLIEITDYAKSISFNFASYMSASKFFKDYALKTNDKSQYLEDYNQHVAIVALYLANGNKAQAKQFISAMVEQRYQPATPTFLNAGRARRGELVSCFLLEVDDSLNSINFIDSTAKQLSKIGGGVAINLSKLRARGEAIKGIKGVAKGVLPIAKSLEGGFSYADQLGQRPGAGAVYLNIFHYDVEEFLDTKKVNADEDLRLSTISTGLIVPSKFFDLAKEGKDFYMFAPHTVKEEYGVTLDDIDLEKYYDDMVANPNVEKKKKNAREMLNLIAQTQLQSGYPYLMFKDNANRVHPNSNIGQIKMSNLCTEIFQLQETSIINDYGIEDEIKRDISCNLGSLNIVNVMESGKFRDSVHSGMDALTVVSDVANIQNAPGVRKANSELHSVGLGVMNLHGYLAKNKIGYESEEAKDFANIFFMMMNFYSIERSMEIAKERGIKYQDFEKSDYANGKYFEFYTTQEFEPQFEKVRELFDGMAIPTSEDWKKLQQDVEQYGLYHAYRLAIAPTQSISYVQNATSSVMPIVDQIERRTYGNAETFYPMPFLSPQTMWYYKSAFNTDQMKLIDLIATIQTHIDQGISTILYVNSEISTRELARLYVYAHYKGLKSLYYTRNKLLSVEECTSCSI
>NC_017340.1|WP_000562498.1|783334_784306_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta
MIAVNWNTQEDMTNMFWRQNISQMWVETEFKVSKDIASWKTLSEAEQDTFKKALAGLTGLDTHQADDGMPLVMLHTTDLRKKAVYSFMAMMEQIHAKSYSHIFTTLLPSSETNYLLDEWVLEEPHLKYKSDKIVANYHKLWGKEASIYDQYMARVTSVFLETFLFFSGFYYPLYLAGQGKMTTSGEIIRKILLDESIHGVFTGLDAQHLRNELSESEKQKADQEMYKLLNDLYLNEESYTKMLYDDLGITEDVLNYVKYNGNKALSNLGFEPYFEEREFNPIIENALDTTTKNHDFFSVKGDGYVLALNVEALQDDDFVFDNK
>NC_017340.1|WP_000499195.1|784486_784642_+|hypothetical-protein
MFYFTLSKQNTHSEKLNFSLIANINKIDTKLFERLLKLWSKNATINEKYYQ
>NC_017340.1|WP_000876318.1|784680_785652_+|ABC-transporter-permease
MKYLLKGNILLLLLILLTIISLFIGVSELSIKDLLHLTESQRNILFSSRIPRTMSILIAGSSLALAGLIMQQMMQNKFVSPTTAGTMEWAKLGILIALLFFPTGHILLKLVFAVICSICGTFLFVKIIDFIKVKDVIFVPLLGIMMGGIVASFTTFISLRTNAVQSIGNWLNGNFAIITSGRYEILYLSIPLLALTYLFANHFTIVGMGKDFTNNLGLSYEKLINIALFITATITALVVVTVGTLPFLGLVIPNIISIYRGDHLKNAIPHTMMLGAIFVLFSDIVGRIVVYPYEINIGLTIGVFGTIIFLILLMKGRKNYAQQ

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Click the colored protein region to show detailed information

Crispr_ID: NC_017340_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017340_4

815748-815826

Unclear

Consensus_repeat	Method
TGTAGAATTTCTTTTCGAAATTCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017340_4

>merge|NC_017340|4|815748-815826|CRISPRCasFinder
TGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCCGCCAACTTGCATTGCCTGTAGAATTTCTTTTCGAAATTCT

>NC_017340|4|4|815748-815826|CRISPRCasFinder
TGTAGAATTTCTTTTCGAAATTCT	CTGTGTTGGGGCCCCGCCAACTTGCATTGCC
TGTAGAATTTCTTTTCGAAATTCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017340.1\|WP_001224793.1\|817869_818355_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NC_017340.1\|WP_001790092.1\|806624_806729_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000638419.1\|810076_810313_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234
NC_017340.1\|WP_000513305.1\|817022_817862_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NC_017340.1\|WP_000662677.1\|812574_815421_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_017340.1\|WP_001248939.1\|822597_823593_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NC_017340.1\|WP_001792175.1\|808161_808269_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000617735.1\|803065_803638_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NC_017340.1\|WP_000538141.1\|809429_810080_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NC_017340.1\|WP_000369722.1\|821689_822601_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NC_017340.1\|WP_000958224.1\|816084_817017_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NC_017340.1\|WP_000816304.1\|826041_826944_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NC_017340.1\|WP_010956549.1\|806897_808008_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NC_017340.1\|WP_000057543.1\|818362_819802_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NC_017340.1\|WP_001049165.1\|825211_825799_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NC_017340.1\|WP_000506531.1\|804051_806583_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NC_017340.1\|WP_000006551.1\|823703_824648_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NC_017340.1\|WP_000753319.1\|808416_809256_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NC_017340.1\|WP_000229241.1\|810581_812567_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_017340.1\|WP_000134963.1\|819868_820804_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540

Protein	Function_ID	Function_description	E-value
NC_017340.1\|WP_000006551.1\|823703_824648_+\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
NC_017340.1\|WP_000638419.1\|810076_810313_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
NC_017340.1\|WP_000513305.1\|817022_817862_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.75588e-120
NC_017340.1\|WP_000662677.1\|812574_815421_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_017340.1\|WP_001248939.1\|822597_823593_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
NC_017340.1\|WP_001224793.1\|817869_818355_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
NC_017340.1\|WP_000617735.1\|803065_803638_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.13584e-37
NC_017340.1\|WP_000538141.1\|809429_810080_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NC_017340.1\|WP_000369722.1\|821689_822601_+\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
NC_017340.1\|WP_000958224.1\|816084_817017_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NC_017340.1\|WP_000816304.1\|826041_826944_-\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	6.73087e-155
NC_017340.1\|WP_010956549.1\|806897_808008_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_017340.1\|WP_000057543.1\|818362_819802_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	4.14043e-06
NC_017340.1\|WP_001049165.1\|825211_825799_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NC_017340.1\|WP_000506531.1\|804051_806583_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NC_017340.1\|WP_000753319.1\|808416_809256_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.97111e-42
NC_017340.1\|WP_000229241.1\|810581_812567_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_017340.1\|WP_000134963.1\|819868_820804_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154

>NC_017340.1|WP_000662677.1|812574_815421_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIDVPEYRRPASDRKISIRGARSNNLKGIDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>NC_017340.1|WP_000229241.1|810581_812567_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVDGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NC_017340.1|WP_000638419.1|810076_810313_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NC_017340.1|WP_000538141.1|809429_810080_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NC_017340.1|WP_000753319.1|808416_809256_+|CHAP-domain-containing-protein
MKKTLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKSPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>NC_017340.1|WP_001792175.1|808161_808269_+|hypothetical-protein
MCLLKQHMQCAFSNITYGDFQGIELIVENVLNYMV
>NC_017340.1|WP_010956549.1|806897_808008_+|peptide-chain-release-factor-2
MELSEIKRNIDKYNQDLTQIRGSLDLENKETNIQEYEEMMAEPNFWDNQTKAQDIIDKNNALKAIVNGYKTLQAEVDDMDATWDLLQEEFDEEMKEDLEQEVINFKAKVDEYELQLLLDGPHDANNAILELHPGAGGTESQDWANMLFRMYQRYCEKKGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPDFNNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPSGIVVNNQNERSQIKNREAAMKMLKSKLYQLKLEEQAREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGDIGPFIESYLRQTMSHD
>NC_017340.1|WP_001790092.1|806624_806729_+|hypothetical-protein
MLWEESFYFTSVKYFKKCEEVVKRCYVLSFKKSV
>NC_017340.1|WP_000506531.1|804051_806583_+|preprotein-translocase-subunit-SecA
MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQNDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPTYLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITYSTNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKQDEDYKYDEKTKAVHLTEQGADKAERMFKVENLYDVQNVDVISHINTALRAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMASITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGKFDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGAGQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGDSRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARKRILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQPFIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILLRSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILKSVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNCHGK
>NC_017340.1|WP_000617735.1|803065_803638_+|ribosome-associated-translation-inhibitor-RaiA
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ
>NC_017340.1|WP_000958224.1|816084_817017_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NC_017340.1|WP_000513305.1|817022_817862_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>NC_017340.1|WP_001224793.1|817869_818355_+|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NC_017340.1|WP_000057543.1|818362_819802_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYQNELFVSENDLMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NC_017340.1|WP_000134963.1|819868_820804_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NC_017340.1|WP_000369722.1|821689_822601_+|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NC_017340.1|WP_001248939.1|822597_823593_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NC_017340.1|WP_000006551.1|823703_824648_+|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>NC_017340.1|WP_001049165.1|825211_825799_+|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NC_017340.1|WP_000816304.1|826041_826944_-|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGMILSNEGGALQTMKLPYKYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE

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Crispr_ID: NC_017340_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017340_5

821203-821472

Unclear

Consensus_repeat	Method
TTCTCTGTGTTGGGGCCCACACCCCAACTNGCATTG	CRT

4 spacers

The CRISPR arrays of NC_017340_5

>merge|NC_017340|5|821203-821472|CRT
GCTTCTGTGTTGGGGCCCACACCCCAACTCGCATTGCCTGTAGAATTTCTTTTCGAAATTCTCTTTGTTGGGGCCCACACCCCAACTTGCATTGTCTGTAGAAATTGGAAATCCAATTTCTCTGTGTTGGGGCCCACACCCCAACTCGCATTGCCTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCACACCCCAACTTGCATTGTCTGTAGAAATTGGAAATCCAATTTCTCTGTGTTGGGGCCCCTGACTAGAGTTGAAAAA

>NC_017340|5|1|821203-821472|CRT
GCTTCTGTGTTGGGGCCCACACCCCAACTCGCATTG	CCTGTAGAATTTCTTTTCGAAA
TTCTCTTTGTTGGGGCCCACACCCCAACTTGCATTG	TCTGTAGAAATTGGAAATCCAAT
TTCTCTGTGTTGGGGCCCACACCCCAACTCGCATTG	CCTGTAGAATTTCTTTTCGAAA
TTCTCTGTGTTGGGGCCCACACCCCAACTTGCATTG	TCTGTAGAAATTGGAAATCCAAT
TTCTCTGTGTTGGGGCCCCTGACTAGAGTTGAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017340.1\|WP_000279414.1\|830154_831165_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|273675
NC_017340.1\|WP_001074749.1\|831303_832494_+\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NC_017340.1\|WP_000134963.1\|819868_820804_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NC_017340.1\|WP_000662677.1\|812574_815421_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_017340.1\|WP_000006551.1\|823703_824648_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NC_017340.1\|WP_001224793.1\|817869_818355_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NC_017340.1\|WP_000654030.1\|829088_830102_+\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NC_017340.1\|WP_000538141.1\|809429_810080_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NC_017340.1\|WP_000369722.1\|821689_822601_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NC_017340.1\|WP_000816304.1\|826041_826944_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NC_017340.1\|WP_000513305.1\|817022_817862_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NC_017340.1\|WP_001260089.1\|832615_833377_+\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589
NC_017340.1\|WP_000057543.1\|818362_819802_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NC_017340.1\|WP_001049165.1\|825211_825799_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NC_017340.1\|WP_001248939.1\|822597_823593_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NC_017340.1\|WP_000958224.1\|816084_817017_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NC_017340.1\|WP_000753319.1\|808416_809256_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NC_017340.1\|WP_000229241.1\|810581_812567_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_017340.1\|WP_000070831.1\|827646_828276_+\|DUF4887-domain-containing-protein	unknown	unknown	gnl\|CDD\|234750
NC_017340.1\|WP_000638419.1\|810076_810313_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234

Protein	Function_ID	Function_description	E-value
NC_017340.1\|WP_000279414.1\|830154_831165_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|273675	TIGR01534, Glyceraldehyde-3-phosphate_dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, type I. This model represents glyceraldehyde-3-phosphate dehydrogenase (GAPDH), the enzyme responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. Forms exist which utilize NAD (EC 1.2.1.12), NADP (EC 1.2.1.13) or either (1.2.1.59). In some species, NAD- and NADP- utilizing forms exist, generally being responsible for reactions in the anabolic and catabolic directions respectively. Two Pfam models cover the two functional domains of this protein; pfam00044 represents the N-terminal NAD(P)-binding domain and pfam02800 represents the C-terminal catalytic domain. An additional form of gap gene is found in gamma proteobacteria and is responsible for the conversion of erythrose-4-phosphate (E4P) to 4-phospho-erythronate in the biosynthesis of pyridoxine. This pathway of pyridoxine biosynthesis appears to be limited, however, to a relatively small number of bacterial species although it is prevalent among the gamma-proteobacteria. This enzyme is described by TIGR001532. These sequences generally score between trusted and noise to this GAPDH model due to the close evolutionary relationship. There exists the possiblity that some forms of GAPDH may be bifunctional and act on E4P in species which make pyridoxine and via hydroxythreonine and lack a separate E4PDH enzyme (for instance, the GAPDH from Bacillus stearothermophilus has been shown to posess a limited E4PD activity as well as a robust GAPDH activity). There are a great number of sequences in the databases which score between trusted and noise to this model, nearly all of them due to fragmentary sequences. It seems that study of this gene has been carried out in many species utilizing PCR probes which exclude the extreme ends of the consenses used to define this model. The noise level is set relative not to E4PD, but the next closest outliers, the class II GAPDH's (found in archaea, TIGR01546) and aspartate semialdehyde dehydrogenase (ASADH, TIGR01296) both of which have highest-scoring hits around -225 to the prior model. [Energy metabolism, Glycolysis/gluconeogenesis].	0
NC_017340.1\|WP_001074749.1\|831303_832494_+\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NC_017340.1\|WP_000134963.1\|819868_820804_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
NC_017340.1\|WP_000662677.1\|812574_815421_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_017340.1\|WP_000006551.1\|823703_824648_+\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
NC_017340.1\|WP_001224793.1\|817869_818355_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
NC_017340.1\|WP_000654030.1\|829088_830102_+\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	1.39665e-92
NC_017340.1\|WP_000538141.1\|809429_810080_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NC_017340.1\|WP_000369722.1\|821689_822601_+\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
NC_017340.1\|WP_000816304.1\|826041_826944_-\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	6.73087e-155
NC_017340.1\|WP_000513305.1\|817022_817862_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.75588e-120
NC_017340.1\|WP_001260089.1\|832615_833377_+\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	2.84083e-146
NC_017340.1\|WP_000057543.1\|818362_819802_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	4.14043e-06
NC_017340.1\|WP_001049165.1\|825211_825799_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NC_017340.1\|WP_001248939.1\|822597_823593_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
NC_017340.1\|WP_000958224.1\|816084_817017_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NC_017340.1\|WP_000753319.1\|808416_809256_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.97111e-42
NC_017340.1\|WP_000229241.1\|810581_812567_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_017340.1\|WP_000070831.1\|827646_828276_+\|DUF4887-domain-containing-protein	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	5.80381e-05
NC_017340.1\|WP_000638419.1\|810076_810313_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34

>NC_017340.1|WP_000134963.1|819868_820804_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NC_017340.1|WP_000057543.1|818362_819802_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYQNELFVSENDLMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NC_017340.1|WP_001224793.1|817869_818355_+|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NC_017340.1|WP_000513305.1|817022_817862_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>NC_017340.1|WP_000958224.1|816084_817017_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NC_017340.1|WP_000662677.1|812574_815421_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIDVPEYRRPASDRKISIRGARSNNLKGIDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>NC_017340.1|WP_000229241.1|810581_812567_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVDGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NC_017340.1|WP_000638419.1|810076_810313_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NC_017340.1|WP_000538141.1|809429_810080_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NC_017340.1|WP_000753319.1|808416_809256_+|CHAP-domain-containing-protein
MKKTLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKSPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>NC_017340.1|WP_000369722.1|821689_822601_+|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NC_017340.1|WP_001248939.1|822597_823593_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NC_017340.1|WP_000006551.1|823703_824648_+|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>NC_017340.1|WP_001049165.1|825211_825799_+|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NC_017340.1|WP_000816304.1|826041_826944_-|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGMILSNEGGALQTMKLPYKYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE
>NC_017340.1|WP_000070831.1|827646_828276_+|DUF4887-domain-containing-protein
MSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERMLNEQKQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAPTKQRPAKEENDDKASKDESKDKDDNASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNNNQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK
>NC_017340.1|WP_000654030.1|829088_830102_+|sugar-binding-transcriptional-regulator
MKDLLQAQQKLIPDLIDKMYKRFSILTTISKNQPVGRRSLSEHMDMTERVLRSETDMLKKQDLIKVKPTGMEITAEGEQLISQLKGYFDIYADDNRLSEGIKNKFQIKEVHVVPGDADNSQSVKTELGRQAGQLLEGILQEDAIVAVTGGSTMACVSEAIHLLPYNVFFVPARGGLGENVVFQANTIAASMAQQAGGYYTTMYVPDNVSETTYNTLLLEPSVINTLDKIKQANVILHGIGDALKMAHRRQSPEKVIEQLQHHQAVGEAFGYYFDTQGQIVHKVKTIGLQLEDLESKDFIFAVAGGKSKGEAIKAYLTIAPKNTVLITDEAAAKIILE
>NC_017340.1|WP_000279414.1|830154_831165_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
>NC_017340.1|WP_001074749.1|831303_832494_+|phosphoglycerate-kinase
MAKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGGKIVLFSHLGKVKEESDKAKLTLRPVAEDLSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKKESKNDPELGKYWASLGDVFVNDAFGTAHREHASNVGISTHLETAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAYTFLKAQGKEIGISLLEEDKIDFAKDLLEKHGDKIVLPVDTKVAKEFSNDAKITVVPSDSIPADQEGMDIGPNTVKLFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLKDAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEYLEGKELPGIKAINNK
>NC_017340.1|WP_001260089.1|832615_833377_+|triose-phosphate-isomerase
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKVEDFVQLLEGAK

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Crispr_ID: NC_017340_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017340_6

864486-864567

Orphan

Consensus_repeat	Method
CCCCAACTTGCATTGTCTGTAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017340_6

>merge|NC_017340|6|864486-864567|CRISPRCasFinder
CCCCAACTTGCATTGTCTGTAGAAATTGAGAATCCAATTTCTCTTTGTTGGGGCCCATCCCCAACTTGCATTGCCTGTAGAA

>NC_017340|6|5|864486-864567|CRISPRCasFinder
CCCCAACTTGCATTGTCTGTAGAA	ATTGAGAATCCAATTTCTCTTTGTTGGGGCCCAT
CCCCAACTTGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017340.1\|WP_000255551.1\|858242_858860_-\|amino-acid-transporter	unknown	unknown	gnl\|CDD\|224198
NC_017340.1\|WP_000168845.1\|870616_871378_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NC_017340.1\|WP_000752917.1\|869009_869204_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
NC_017340.1\|WP_001018962.1\|865178_865565_+\|topiosmerase	unknown	unknown	gnl\|CDD\|224572
NC_017340.1\|WP_000150011.1\|860477_861194_+\|type-I-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|184156
NC_017340.1\|WP_001065801.1\|865557_865854_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_017340.1\|WP_000732324.1\|867834_868656_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NC_017340.1\|WP_000520231.1\|867121_867817_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NC_017340.1\|WP_000569884.1\|859014_859509_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|372596
NC_017340.1\|WP_000205567.1\|871475_872783_+\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NC_017340.1\|WP_000571213.1\|866103_867129_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224058
NC_017340.1\|WP_001006450.1\|872888_874139_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NC_017340.1\|WP_001147952.1\|861966_862287_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_017340.1\|WP_000974460.1\|859907_860330_-\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649
NC_017340.1\|WP_000422908.1\|861276_861816_+\|nitroreductase	unknown	unknown	gnl\|CDD\|380312
NC_017340.1\|WP_001183854.1\|869437_870289_-\|DUF368-domain-containing-protein	unknown	unknown	gnl\|CDD\|224946
NC_017340.1\|WP_000932225.1\|863503_864382_+\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|226395
NC_017340.1\|WP_000589549.1\|862430_862787_+\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239334
NC_017340.1\|WP_001140693.1\|857588_858170_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NC_017340.1\|WP_000290491.1\|862944_863325_+\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918

Protein	Function_ID	Function_description	E-value
NC_017340.1\|WP_000255551.1\|858242_858860_-\|amino-acid-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	2.60719e-61
NC_017340.1\|WP_000168845.1\|870616_871378_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	1.29081e-150
NC_017340.1\|WP_000752917.1\|869009_869204_+\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	5.95583e-07
NC_017340.1\|WP_001018962.1\|865178_865565_+\|topiosmerase	gnl\|CDD\|224572	COG1658, COG1658, Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair].	2.45102e-36
NC_017340.1\|WP_000150011.1\|860477_861194_+\|type-I-3-dehydroquinate-dehydratase	gnl\|CDD\|184156	PRK13575, PRK13575, type I 3-dehydroquinate dehydratase.	3.2619e-146
NC_017340.1\|WP_001065801.1\|865557_865854_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	7.01368e-14
NC_017340.1\|WP_000732324.1\|867834_868656_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	1.02861e-112
NC_017340.1\|WP_000520231.1\|867121_867817_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	7.66296e-99
NC_017340.1\|WP_000569884.1\|859014_859509_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|372596	pfam13420, Acetyltransf_4, Acetyltransferase (GNAT) domain.	2.53639e-47
NC_017340.1\|WP_000205567.1\|871475_872783_+\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	3.36148e-135
NC_017340.1\|WP_000571213.1\|866103_867129_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	2.03316e-170
NC_017340.1\|WP_001006450.1\|872888_874139_+\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NC_017340.1\|WP_001147952.1\|861966_862287_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.4922e-24
NC_017340.1\|WP_000974460.1\|859907_860330_-\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	5.58225e-61
NC_017340.1\|WP_000422908.1\|861276_861816_+\|nitroreductase	gnl\|CDD\|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	2.10032e-49
NC_017340.1\|WP_001183854.1\|869437_870289_-\|DUF368-domain-containing-protein	gnl\|CDD\|224946	COG2035, COG2035, Predicted membrane protein [Function unknown].	7.67366e-77
NC_017340.1\|WP_000932225.1\|863503_864382_+\|DUF1963-domain-containing-protein	gnl\|CDD\|226395	COG3878, COG3878, Uncharacterized protein conserved in bacteria [Function unknown].	3.13065e-77
NC_017340.1\|WP_000589549.1\|862430_862787_+\|arsenate-reductase-family-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	1.06191e-56
NC_017340.1\|WP_001140693.1\|857588_858170_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	5.2875e-48
NC_017340.1\|WP_000290491.1\|862944_863325_+\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	9.01516e-70

>NC_017340.1|WP_000932225.1|863503_864382_+|DUF1963-domain-containing-protein
MLNIQDVSHLSKKEQKAYNRFVESVENGNLPVLPCIEMDLKEMQEETLSQSKIGGMPFLKSFKDIPLDENNVPMVLLAQINLNDLPEQQELFPVNEGILQFWISSEDQMYGMSENLKGNNINSRLVYIKEPITDLSLENIQVHLKSLDADNEDIPFSGAFSIEFRLSKQTITCTDYKYDEDVLALWNKVNPSFALKSMFGGYDELMEPVCNTFTAKEPFNQLGGYPYFDQIDPRTNDQELKMYDRVLLQIDSTRDGNSSIIWGDLGIANILVKSTDLEAMKFDDYMYSWDCS
>NC_017340.1|WP_000290491.1|862944_863325_+|glycine-cleavage-system-protein-GcvH
MAVPNELKYSKEHEWVKVEGNVATIGITEYAQSELGDIVFVELPETDDEINEGDTFGSVESVKTVSELYAPISGKVVEVNEELEDSPEFVNESPYEKAWMVKVEISDESQLEALLTAEKYSEMIGE
>NC_017340.1|WP_000589549.1|862430_862787_+|arsenate-reductase-family-protein
MIKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTGVEINKLFNTHGAKYRELDLKNKLQTLSDDEKLELLSSDGMLVKRPLAVMGDKITLGFKEDQYKETWLA
>NC_017340.1|WP_001147952.1|861966_862287_-|thioredoxin-family-protein
MQAIKSNESFKSIINSDTPVIVKFEAGWCPDCRAMDLWIDPIVEQYNDYQWYTVNRDELEDVVVENEVMGIPSLLVFKNGDKIAHLHSANAKSPEQVESFLAETFK
>NC_017340.1|WP_000422908.1|861276_861816_+|nitroreductase
MELQQAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFAFPNELDKQQCHYDAVTKLGGMLLLILKTDPRQRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYLTDLEEDMPKAPRKNRNLITLY
>NC_017340.1|WP_000150011.1|860477_861194_+|type-I-3-dehydroquinate-dehydratase
MTHVEVVATIAPQLSIEETLIQKINHRIDAIDVLELRIDQIENVTVDQVAEMITKLKVMQDSFKLLVTYRTKLQGGYGQFINDLYLNLISDLANINGIDMIDIEWQADIDIEKHQRIIKHLQQYNKEVVISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMSTFSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGEPQAPGQIDVTDLKAQVTLY
>NC_017340.1|WP_000974460.1|859907_860330_-|organic-hydroperoxide-resistance-protein
MAIHYETKATNVGGRKGHVYTDDRALDIDIVPPAQADGKATNPEQLFAAGYASCFNGAFDLILKQNKVRDAHPEVTLTVRLEDDSDSESPKLSVSIDATIKNVISQEEAEKYLQMAHEFCPYSKATQGNINVDLNVNVVD
>NC_017340.1|WP_000569884.1|859014_859509_-|GNAT-family-N-acetyltransferase
MIEIKTLTNNDFNEYKRLVSTVNEEFTQDSHYSQTMTDTLIHDILNQGSPKCIVFGCYENETLIATAALEQIRYVGKEHKSLIKYNFVTNNDKSINSELINFIINYARQNNYESLLTSIVSNNIGAKVFYSALGFDILGFEKNAIKIGNTYFDEHWLFYDLINK
>NC_017340.1|WP_000255551.1|858242_858860_-|amino-acid-transporter
MVTAIIHGFILAIGLILPLGAQNVFIFNQGANQPKYRYVLPAIITAGLSDSLLIIIAVVGVSIIIMSLPVLQAIIYIVGLIFLMYMAWTIWHDKPSTDGEAQIISPMKQVSFALSVSLLNPHAILDTIGVIGSSAALYSGSNKIAFTIACISVSWLWFFLLAILGKMVGSIDKTGKLLTIINKISSIIIIIVALMILQKLIQLLF
>NC_017340.1|WP_001140693.1|857588_858170_+|histidine-phosphatase-family-protein
MAKTLYLMRHGQTLFNFKGLIQGFGDSPLTELGIAQAQKARSYYETKGINFDLYASSTQERASDTLENVAPNQSYQRFKGLKEWHFGIFEGESVYLFDNLYKPEDLFGDRIVPFKGEARQQVEERIVKTLHDIMSQTKNNALVVSHGTIMGVFLRYCLKLDEALKHNIGNCNILKFEYDNGTFKFVELIDPNL
>NC_017340.1|WP_001018962.1|865178_865565_+|topiosmerase
MAIVNKVIIVEGKSDKKRVQQVIAEPVNIICTHGTMSIDKLDDMIESLYDKQVFVLADSDDEGDRIRNWFKRYLSESEHIFIDKTYCQVANCPKQYLAHVLSKHGFTCKKETPLLPNINNERLVLVNE
>NC_017340.1|WP_001065801.1|865557_865854_+|thioredoxin-family-protein
MNNSLDIKDVTTFYEEDKHLIFGYTPTCGTCKVSERMLDIANEILQLPLLKIDLNFYPQFCKDMQIMSTPILLLMNKDKEVKRIYAFKSVTDLLENLK
>NC_017340.1|WP_000571213.1|866103_867129_+|methionine-ABC-transporter-ATP-binding-protein
MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIVLITHEMHVIRRICDEVAVMESGKVIEHGPVTQVFENPQHTVTKRFVKEDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSVDFGKFEKELIERQVKMEVLRHG
>NC_017340.1|WP_000520231.1|867121_867817_+|ABC-transporter-permease
MGKSFSEIINEMITMPNIQWPEVWTAIVETLYMTVVSTIFAFILGLILGVLLFLSAKGKSIGARLFYSIVSFIVNLFRAIPFIILILLLIPFTSLILGTISGPTGALPALIIGAAPFYARLVEIAFKEIDKGVIEAAWSMGANTWIVIRKVLLPEAMPALVSGITVTAIALVGSTAVAGVIGAGGLGNLAYLTGFTRNQNDVILVSTVFILIIVFIIQFIGDWLTNKLDKR
>NC_017340.1|WP_000732324.1|867834_868656_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKLFGLILVLTFAVVLAACGNGNKSGSDDKKITVGASPAPHAEILEKAKPLLEKKGYDLDIKTINDYTTPNKLLDKGEIDANYFQHTPYLNTEKKDKGYKIVSAGDVHLEPMAVYSKKYKSLKELPKGATVYVSNNPAEQGRFLKFFVDAGLIKIKKGVKIEDAKFSDITENKKDIKFNNKQSAEFLPKIYQNEDADAVIINSNFAIEQKLNPKKDSIAVESAKDNPYANLIAVKEGHQDDKKIKALIEVLQSKDIQDFINEKYNGAVIPAK
>NC_017340.1|WP_000752917.1|869009_869204_+|CsbD-family-protein
MADESKFEQAKGNVKETVGNVTDNKNLENEGKEDKASGKAKEFVENAKEKATDFIDKVKGNKGE
>NC_017340.1|WP_001183854.1|869437_870289_-|DUF368-domain-containing-protein
MQQFKWINILKGFAMGTSDLVPGVSGGTIALLLGIYNQFIASISGIFSRRFWPSFTFLIPIIIGMLLAMGSLSNLFNYLLSQHHIPTMFFFGGLIIGIVPYLLKISNYKTSFTTKHYMMVIAGIAILIVITLMNNGDKHAGETLTLSTGLIIKYFIAGMCASSAMLLPGISGSFMLLVFGVYGTVMLAISEVVKLNFTGLPILLAVGFGVLAGFIISSKIIQYFLTHHKLMTFALIIGFVVGSLFAVFPGLPTNIVMWFVSLVVFIIGFIVSLTLGRITAENE
>NC_017340.1|WP_000168845.1|870616_871378_+|Fe-S-cluster-assembly-ATPase-SufC
MASTLEIKDLHVSIEDKEILKGVNLTINTDEIHAIMGPNGTGKSTLSSAIMGHPSYEVTKGEVLLDGVNILELEVDERAKAGLFLAMQYPSEITGVTNADFMRSAINAKREEGQEINLMQFIKKLDKNMDFLDIDKDMAQRYLNEGFSGGEKKRNEILQLMMLEPKFAILDEIDSGLDIDALKVVSKGINQMRGENFGALMITHYQRLLNYITPDKVHVMYAGKVVKSGGPELAKRLEEEGYEWVKEEFGSAE
>NC_017340.1|WP_000205567.1|871475_872783_+|Fe-S-cluster-assembly-protein-SufD
MTTDILNISEEQLVDYSKAHNEPSWMTELRKKALKLTETLEMPKPDKTKLRKWDFDSFKQHDVKGDVYQSLSQLPESVREIIDVDHSKNLVIQHNNTIAYTQVDDNASKDGVIVEGLADALMNHSDLVQKHFMKDAVTVDEHRITALHTALVNGGVFVYVPKNVVVEHPVQYVVLHDDKNASFYNHVIIVTEESAEVTYVENYLSNASGEGNQLNIISEVIAGANSNITYGSVDYMDKGFTGHIIRRGITEADASINWALGLMNEGSQIIDNTTNLFGDRSTSSLKSVVVGTGEQKINLTSKIVQYGKETDGYILKHGVMKEHASSVFNGIGYIKHGGTKSIANQESRVLMLSEHARGDANPILLIDEDDVQAGHAASVGRVDPDQLYYLMSRGISQREAERLVIHGFLDPVVRELPIEDVKRQLREVIERKVSK
>NC_017340.1|WP_001006450.1|872888_874139_+|cysteine-desulfurase
MNEVAEHSFDVNEVIKDFPILDQKVNGKRLAYLDSTATSQTPMQVLNVLEDYYKRYNSNVHRGVHTLGSLATDGYENARETVRRFINAKYFEEIIFTRGTTASINLVAHSYGDANVEEGDEIVVTEMEHHANIVPWQQLAKRKNATLKFIPMTADGELNIEDIKQTINDKTKIVAIAHISNVLGTINDVKTIAEIAHQHGAIISVDGAQAAPHMKLDMQEMNADFYSFSGHKMLGPTGIGVLFGKRELLQKMEPIEFGGDMIDFVSKYDATWADLPTKFEAGTPLIAQAIGLAEAIRYLERIGFDAIHKYEQELTIYAYEQMSAIEGIEIYGPPKDRRAGVITFNLQDVHPHDVATAVDTEGVAVRAGHHCAQPLMKWLNVSSTARASFYIYNTKEDIDQLINALKQTKEFFSYEF

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Click the colored protein region to show detailed information

Crispr_ID: NC_017340_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017340_7

1653135-1653219

Orphan

Consensus_repeat	Method
CACCCCAACTTGCATTGTCTGTAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017340_7

>merge|NC_017340|7|1653135-1653219|CRISPRCasFinder
CACCCCAACTTGCATTGTCTGTAGAAATTGGGAATCCAATTTCTCTGTGTTGGGGCCCACACCCCAACTTGCATTGCCTGTAGAA

>NC_017340|7|6|1653135-1653219|CRISPRCasFinder
CACCCCAACTTGCATTGTCTGTAGAA	ATTGGGAATCCAATTTCTCTGTGTTGGGGCCCA
CACCCCAACTTGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017340.1\|WP_001019328.1\|1661445_1662030_-\|bis(5'-nucleosyl)-tetraphosphatase-(symmetrical)-YqeK	unknown	unknown	gnl\|CDD\|224627
NC_017340.1\|WP_001802667.1\|1642344_1643028_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223961
NC_017340.1\|WP_000368338.1\|1653391_1655215_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NC_017340.1\|WP_001274017.1\|1655560_1655812_+\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|178943
NC_017340.1\|WP_000627144.1\|1650623_1651601_-\|heat-inducible-transcription-repressor-HrcA	unknown	unknown	gnl\|CDD\|273017
NC_017340.1\|WP_001104607.1\|1645847_1646786_-\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|283886
NC_017340.1\|WP_000084830.1\|1660372_1661089_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_017340.1\|WP_000218103.1\|1651701_1652826_-\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309
NC_017340.1\|WP_000034716.1\|1648064_1649897_-\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NC_017340.1\|WP_001282563.1\|1655856_1656831_-\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|235511
NC_017340.1\|WP_000725167.1\|1662019_1662589_-\|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|273101
NC_017340.1\|WP_000439693.1\|1659093_1659555_-\|ComE-operon-protein-2	unknown	unknown	gnl\|CDD\|131622
NC_017340.1\|WP_001557362.1\|1656887_1659089_-\|DNA-internalization-related-competence-protein-ComEC/Rec2	unknown	unknown	gnl\|CDD\|225212
NC_017340.1\|WP_001119021.1\|1646789_1647929_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|237656
NC_017340.1\|WP_001190120.1\|1645093_1645846_-\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl\|CDD\|224303
NC_017340.1\|WP_000048060.1\|1643271_1643448_-\|30S-ribosomal-protein-S21	unknown	unknown	gnl\|CDD\|234707
NC_017340.1\|WP_001088020.1\|1661091_1661445_-\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|223870
NC_017340.1\|WP_001802022.1\|1659646_1660333_-\|ComEA-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|224472
NC_017340.1\|WP_000108667.1\|1643740_1645087_-\|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB	unknown	unknown	gnl\|CDD\|223694
NC_017340.1\|WP_000182211.1\|1649965_1650592_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|237622

Protein	Function_ID	Function_description	E-value
NC_017340.1\|WP_001019328.1\|1661445_1662030_-\|bis(5'-nucleosyl)-tetraphosphatase-(symmetrical)-YqeK	gnl\|CDD\|224627	COG1713, COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism].	7.78994e-81
NC_017340.1\|WP_001802667.1\|1642344_1643028_-\|hypothetical-protein	gnl\|CDD\|223961	COG1030, NfeD, Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones].	8.78003e-63
NC_017340.1\|WP_000368338.1\|1653391_1655215_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_017340.1\|WP_001274017.1\|1655560_1655812_+\|30S-ribosomal-protein-S20	gnl\|CDD\|178943	PRK00239, rpsT, 30S ribosomal protein S20; Reviewed.	1.42889e-17
NC_017340.1\|WP_000627144.1\|1650623_1651601_-\|heat-inducible-transcription-repressor-HrcA	gnl\|CDD\|273017	TIGR00331, Heat-inducible_transcription_repressor_HrcA, heat shock gene repressor HrcA. HrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures. In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene. [Regulatory functions, DNA interactions].	2.05887e-119
NC_017340.1\|WP_001104607.1\|1645847_1646786_-\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|283886	pfam06325, PrmA, Ribosomal protein L11 methyltransferase (PrmA). This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.	9.7051e-134
NC_017340.1\|WP_000084830.1\|1660372_1661089_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	7.79783e-16
NC_017340.1\|WP_000218103.1\|1651701_1652826_-\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0
NC_017340.1\|WP_000034716.1\|1648064_1649897_-\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NC_017340.1\|WP_001282563.1\|1655856_1656831_-\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|235511	PRK05574, holA, DNA polymerase III subunit delta; Reviewed.	4.1415e-104
NC_017340.1\|WP_000725167.1\|1662019_1662589_-\|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase	gnl\|CDD\|273101	TIGR00482, Probable_nicotinate-nucleotide_adenylyltransferase, nicotinate (nicotinamide) nucleotide adenylyltransferase. This model represents the predominant bacterial/eukaryotic adenylyltransferase for nicotinamide-nucleotide, its deamido form nicotinate nucleotide, or both. The first activity, nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1), synthesizes NAD by the salvage pathway, while the second, nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) synthesizes the immediate precursor of NAD by the de novo pathway. In E. coli, NadD activity is biased toward the de novo pathway while salvage activity is channeled through the multifunctional NadR protein, but this division of labor may be exceptional. The given name of this model, nicotinate (nicotinamide) nucleotide adenylyltransferase, reflects the lack of absolute specificity with respect to substrate amidation state in most species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides].	2.64141e-76
NC_017340.1\|WP_000439693.1\|1659093_1659555_-\|ComE-operon-protein-2	gnl\|CDD\|131622	TIGR02571, putative_dCMP_deaminase, ComE operon protein 2. This protein is found in the ComE operon for "late competence" as characterized in B. subtilis. Proteins in this family contain homology to a cytidine/deoxycytidine deaminase domain family (pfam00383), and may carry out this activity.	4.81051e-102
NC_017340.1\|WP_001557362.1\|1656887_1659089_-\|DNA-internalization-related-competence-protein-ComEC/Rec2	gnl\|CDD\|225212	COG2333, ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only].	3.64233e-90
NC_017340.1\|WP_001119021.1\|1646789_1647929_-\|molecular-chaperone-DnaJ	gnl\|CDD\|237656	PRK14280, PRK14280, molecular chaperone DnaJ.	0
NC_017340.1\|WP_001190120.1\|1645093_1645846_-\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl\|CDD\|224303	COG1385, COG1385, Uncharacterized protein conserved in bacteria [Function unknown].	1.90273e-91
NC_017340.1\|WP_000048060.1\|1643271_1643448_-\|30S-ribosomal-protein-S21	gnl\|CDD\|234707	PRK00270, rpsU, 30S ribosomal protein S21; Reviewed.	1.15423e-10
NC_017340.1\|WP_001088020.1\|1661091_1661445_-\|ribosome-silencing-factor	gnl\|CDD\|223870	COG0799, COG0799, Uncharacterized homolog of plant Iojap protein [Function unknown].	5.95861e-47
NC_017340.1\|WP_001802022.1\|1659646_1660333_-\|ComEA-family-DNA-binding-protein	gnl\|CDD\|224472	COG1555, ComEA, DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair].	1.06297e-33
NC_017340.1\|WP_000108667.1\|1643740_1645087_-\|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB	gnl\|CDD\|223694	COG0621, MiaB, 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis].	0
NC_017340.1\|WP_000182211.1\|1649965_1650592_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|237622	PRK14140, PRK14140, heat shock protein GrpE; Provisional.	3.74407e-81

>NC_017340.1|WP_000218103.1|1651701_1652826_-|oxygen-independent-coproporphyrinogen-III-oxidase
MTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYRNLKTMYVGGGTPTALSINQLERLLKAIRDTFTITGEYTFEANPDELTKEKVQLLEKYGVNRISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKSISLDLMYHLPKQTIEDFEQSLDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQYEISNFALDGHESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKAILVSNKPSLTERMEEEMFLGLRLNEGVSSSRFKKKFDQSIESVFGQTINNLKEKELIVEKNDAIALTKRGKVIGNEVFEAFLIND
>NC_017340.1|WP_000627144.1|1650623_1651601_-|heat-inducible-transcription-repressor-HrcA
MITDRQLSILNAIVEDYVDFGQPVGSKTLIERHNLNVSPATIRNEMKQLEDLNYIEKTHSSSGRSPSQLGFRYYVNRLLEQTSHQKTNKLRRLNQLLVENQYDVSSALTYFADELSNISQYTTLVVHPNHKQDIINNVHLIRANPNLVIMVIVFSSGHVEHVHLASDIPFSNDKLNTISNFVTNKLTEFNQNLQDDIVSFVQSEQEEIFINKLINTMNNHISNQSNSIYMGGKVKLIDALNESNVSSIQPILQYIESNRIAELLQDISSPNINVKIGNEIDDSLSDISIVTSQYHFDETLKGQIAVIGPTAMHYQNVIQLLNRIW
>NC_017340.1|WP_000182211.1|1649965_1650592_-|nucleotide-exchange-factor-GrpE
MTNKDESVEKNTESTVEETNIKQNIDDSVEQAEESKGHLQDEAIEETSDENVIEEIDPKDQKINELQQLADENEEKYLRLYAEFENYKRRIQKENEINKTYQAQRVLTDILPAIDNIERALQIEGDDETFKSLQKGVQMVHESLINALKDNGLEVIKTEGEAFDPNIHQAVVQDDNPDFESGEITQELQKGYKLKDRVLRPSMVKVNQ
>NC_017340.1|WP_000034716.1|1648064_1649897_-|molecular-chaperone-DnaK
MSKIIGIDLGTTNSCVTVLEGDEPKVIQNPEGSRTTPSVVAFKNGETQVGEVAKRQAITNPNTVQSIKRHMGTDYKVDIEGKSYTPQEISAMILQNLKNTAESYLGEKVDKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDKDEKVLVFDLGGGTFDVSILELGDGVFEVLSTAGDNKLGGDDFDQVIIDYLVAEFKKENGVDLSQDKMALQRLKDAAEKAKKDLSGVSQTQISLPFISAGENGPLHLEVNLTRSKFEELSDSLIRRTMEPTRQAMKDAGLTNSDIDEVILVGGSTRIPAVQEAVKKEIGKEPNKGVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIEILGGRMNTLIERNTTIPTSKSQIYSTAVDNQPSVDVHVLQGERPMAADNKTLGRFQLTDIPPAERGKPQIEVTFDIDKNGIVNVTAKDLGTNKEQRITIQSSSSLSDEEIDRMVKDAEVNAEADKKRREEVDLRNEADSLVFQVEKTLTDLGENIGEEDKKSAEEKKDALKTALEGQDIEDIKSKKEELEKVIQELSAKVYEQAAQQQQQAQGANAGQNNDSTVEDAEFKEVKDDDKK
>NC_017340.1|WP_001119021.1|1646789_1647929_-|molecular-chaperone-DnaJ
MAKRDYYEVLGISKDASKDEIKKAYRKLSKKYHPDINKEEGADEKFKEISEAYEVLSDDNKRASYDQFGHDGPQGFGGQGFNGSDFGGFSGFGGGGFEDIFSSFFGGGRQRDPNAPQKGDDLQYTMTLTFEEAVFGTTKEISIRKDVTCETCHGDGAKPGTSKKTCSYCNGAGHVAVEQNTILGRVRTEQVCPKCNGSGQEFEEACPTCHGKGTENKTVKLEVKVPEGVDNEQQIRLAGEGSPGVNGGPAGDLYVVFRVKPSETFKRDGDDIYYKLNVSFPQAALGDEIKIPTLNNEVMLTIPAGTQTGKQFRLKEKGIKNVHGYGYGDLYVDIKVVTPTKLTDRQKELMKEFAQLNGEEINEQPSNFKDRAKRFFKGE
>NC_017340.1|WP_001104607.1|1645847_1646786_-|50S-ribosomal-protein-L11-methyltransferase
MNWTELSIIINHEAVELATNILENHGSNGVVIEDSDDLINQPEDKYGEIYALKKEDYPDKGVRLKAYFNEMTYDDKLRQQIKDELLNLDELDQHNIQFSEQIIAETDWENEWKNYFHPFRASKKFTIVPSWETYAKEADEELCIELDPGMAFGTGDHPTTSMCLKAIETYVLPQHSVIDVGTGSGILSIASHLIGVKRIKALDIDEMAVSVAKENFRRNHCETLIEAVPGNLLKDETEKFDIVIANILAHIIDEMIEDAYNTLNEGGYFITSGIIKEKYEGIQSHMERVGFKIISEQHDNGWVCLVGQKVSE
>NC_017340.1|WP_001190120.1|1645093_1645846_-|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MQRYFIDQNADVSQRFFITKKEDIHHITNVMRYDVGSKIILTFNDQTVYLCEIADITSDKIAVDLKEKQNINTELPVDVTICSGLIKADKYEWLLQKATELGASSFIAVSMERSIVKLNEAKVVKKIERWQKIIKEAAEQSYRLVIPSIQFESNLKLICDTIDNYDYILIAYEEEAKDGELSNFKQTLQQFKAQDKVLMIFGPEGGLSENEISLFSNTSTVVGLGPRILRAETAPLYALSAISYEKELMG
>NC_017340.1|WP_000108667.1|1643740_1645087_-|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB
MSTVAFHTLGCKVNHYETEAIWQLFKEANYERVDFEANADVFVINTCTVTNTGDKKSRQIIRRAIRQNPDAVICVTGCYAQTSSAEIMEIPGVDVVVGTQDRHKLLGYIDEFRKERQPINGVGNIMKNRKYEELDVPYFTDRTRASLKIQEGCNNFCTFCIIPWARGLMRSRDPEKVVEQATQLVNSGYKEIVLTGIHTGGYGQDLKDYNLAQLLRDLETINGLERIRISSIEASQLTDEVIDVLERSTKVVRHLHIPLQSGSDTVLKRMRRKYTMDRFSERLTKLHKALPDLAVTSDVIVGFPGETEAEFQETYDFIVKHKFSELHVFPYSPRIGTPAARMDDQIDEEIKNERVHKLITLSNQLGKLYASKFDQDVLEVIPEEQGDTEGTLVGYADNYMKVQFEGDESLIGQIVKVKITQANYPLNEGQAIKVVDFATNKSDREVLV
>NC_017340.1|WP_000048060.1|1643271_1643448_-|30S-ribosomal-protein-S21
MSKTVVRKNESLEDALRRFKRSVSKSGTIQEVRKREFYEKPSVKRKKKSEAARKRKFK
>NC_017340.1|WP_001802667.1|1642344_1643028_-|hypothetical-protein
MTTILESTAGDTWVEQVSNIIVQPIFTLILTCLTFLGFVYQLYSKKINAAGIIATLSLLILFLGFLIQGNVNMHSILIFSIGVILVVIELFVVGAVIGIIGMILITISITTLGDNLLFMLANVIVALILTIVEWVILVKIFNRKIPFLDKVILKDSTNSESGYNSHDNRSHLVGKTAQTVTDLRPAGIIFCENERIDAVSDGNFILRNKTVKILEVEGTRVVVREVD
>NC_017340.1|WP_000368338.1|1653391_1655215_-|elongation-factor-4
MDNEQRLKRRENIRNFSIIAHIDHGKSTLADRILENTKSVETRDMQDQLLDSMDLERERGITIKLNAVRLKYEAKDGNTYTFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNELELLPVINKIDLPAAEPERVKQEIEDMIGLDQDDVVLASAKSNIGIEEILEKIVEVVPAPDGDPEAPLKALIFDSEYDPYRGVISSIRIVDGVVKAGDKIRMMATGKEFEVTEVGINTPKQLPVDELTVGDVGYIIASIKNVDDSRVGDTITLASRPASEPLQGYKKMNPMVYCGLFPIDNKNYNDLREALEKLQLNDASLEFEPESSQALGFGYRTGFLGMLHMEIIQERIEREFGIELIATAPSVIYQCILRDGSEVTVDNPAQMPDRDKIDKIFEPYVRATMMVPNDYVGAVMELCQRKRGQFINMDYLDDIRVNIVYELPLAEVVFDFFDQLKSNTKGYASFDYEFIENKESNLVKMDILLNGDKVDALSFIVHRDFAYERGKALVEKLKTLIPRQQFEVPVQAAIGQKIVARTNIKSMGKNVLAKCYGGDISRKRKLLEKQKAGKAKMKAVGNVEIPQDAFLAVLKMDDE
>NC_017340.1|WP_001274017.1|1655560_1655812_+|30S-ribosomal-protein-S20
MANIKSAIKRVKTTEKAEARNISQKSAMRTAVKNAKTAVSNNADNKNELVSLAVKLVDKAAQSNLIHSNKADRIKSQLMTANK
>NC_017340.1|WP_001282563.1|1655856_1656831_-|DNA-polymerase-III-subunit-delta
MSDNIVAIYGDVPELVEKQSAEIISQFLKSDRDDFNFVKYNLYETEIAPIVEETLTLPFFSDKKAILVKNAYIFTGEKAPKDMAHNVDQLIEFIEKYDGENLIVFEIYQNKLDERKKLTKTLKKHARLKKIEQMSEEEIKKWIQSKLNENFKDIKRDALDLFIELTGINFNIVSQEIEKLILFLGDRPTINKQDVNQIINRSLEQNVFLLTEYIQKRKKEQAIHLVKDLITMKEEPIKLLALITSNYRLFYQCKILSQKGYSGQQIAKTIGVHPYRVKLALGQVRHYQLDELLNIVDACAETDYKLKSSYMDKQLILELFILSL
>NC_017340.1|WP_001557362.1|1656887_1659089_-|DNA-internalization-related-competence-protein-ComEC/Rec2
MLYVALSMIVGVLWNSSKVLSTFLFILLLYITYRKNKIVYAPISLFLIIFSSWYLHYSQQAIFNYINYIERNSQFNERAQVIQIQRQGSDTYKGRLSLKNEIYPFFLTDKKNFDLKKIESRNCIVKGQFKVNENKFVTLKLQSIVVQSCLESNRSNLIEKHKQFIMNRIYDSGIKFPDRIMALITGDVKEINEQFKERVKEIGIYHLLAVSGSHIAAIVFLIYQPLKRLNLPLFVIKGITIIVLTLYAQYTNYAPSAVRAIIMTTLVLLITKQIKIKGIQLLAFAFIIMFILNPLVVYDIGFQFSFIISFFIMLLFPFLQQLSKLQSLFIITFIAQLASFIVAIPNFHQLQWVGFLSNLIFVPYYSIILFPLSILFFITSHFIVGLTPLNYLVDLSFNFHDWLLDLFTRIKQSHFSVPKFNDWIFIIFIISVYYIFWLLAKRKYILVTFWTIIILTLLITFPTNSHHKITMLNVGQGDSILYEGGKNQNVLIDTGGKVIDDTKQPSYSISKYHILPTLNERGINELEYLILTHPHNDHIGEVEYIISHIKIKHIVIYNKGYSSNTLMLLSKLSHKYNIKLMDVRQVSSFKLGDSSFLFFDSFIPNSRDKNEYSIITMITYQNKKVLLMGDASKNNESLLLKKYNLPEIDILKVGHHGSKTSSSKEFIEMIKPKISLISSGKNNMYHLPNIEVVKRLQRIRSRIYNSQQNGQVTIDLDDNLKVDSNSYGNASGL
>NC_017340.1|WP_000439693.1|1659093_1659555_-|ComE-operon-protein-2
MERIKWEEYFMAQSHLLALRSTCQRLSVGATIVKDNRIIAGGYNGSVAGEVHCIDEGCLIEDGHCIRTIHAEMNALLQCAKQGVSTEGATIYVTHFPCLNCTKSIIQAGIKRIYYAEDYHNHEYATKLLKQSGIEFKKIPFSPEYVAKYLTKG
>NC_017340.1|WP_001802022.1|1659646_1660333_-|ComEA-family-DNA-binding-protein
MVLLYQFLLRYKDFLTQWKLYIISAVVLIMVLIGFIFWRQDDYTSRNFENKDTALKQSTSENNSLSKLEDVQVKDGDNSKNKGPVYVDVKGAVKHPNVYKMTSKDRVVDLLDKAQLLDDADVSRINLSEKLTDQKMIFIPHKGQKNVEPQIEVNSVHVKNGNTNNTKVNLNTASVSELMSVPGVGQAKANAIVEYRNQQGAFQEIDDLKKVKGFGSKTFDKLKSYFTI
>NC_017340.1|WP_000084830.1|1660372_1661089_-|class-I-SAM-dependent-methyltransferase
MSQYAEMSLVYDQLTQDQPYEKWFEIVKNHCKDESNILDIGCGTGSLTVQLEALGNVTGMDLSVDMLTVAAQKSANVNWLEGDMTSFDLQQQFDIITIFCDSLNYLQDETAVIETFINVYHHLTDSGVFIFDVHTVYKMMTLFNNQSYIDDKGDIFLAWDAVQGDLPLSVYHDMTFFIRHEDETYSRFDESHFQRTFDEKTYLSWLAQVGFKHVETFTDFNIDEHNEDTERLFFIAKK
>NC_017340.1|WP_001088020.1|1661091_1661445_-|ribosome-silencing-factor
MNSQELLAIAVDAIDNKKGEDTISLEMKGISDMTDYFVVTHGNNERQVQAIARAVKEVANEQNIEVKRMEGYNEARWILIDLADVVVHVFHKDERNYYNIEKLYQDAPLESYGQVAY
>NC_017340.1|WP_001019328.1|1661445_1662030_-|bis(5'-nucleosyl)-tetraphosphatase-(symmetrical)-YqeK
MNIEKAKRLVKEKLPEKRYNHSLRVAETAIKLAEIYDGDTSKVELAGVLHDFCKYDDLGKMYQIVRQYELGNDLLSYGSEILHGPVCAAIMEHEYGINDEEVLMAIKYHTTGRQQMTKTEKLIFIADYIEPGRTIPGVDDIRDMAYNQGSLDKTIYEISKRTVLFLIQKDITVYNKTIDCLNYYNYSDERIKDD
>NC_017340.1|WP_000725167.1|1662019_1662589_-|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase
MKKIVLYGGQFNPIHTAHMIVASEVFHELQPDEFYFLPSFMSPLKKHNNFIDVQHRLTMIQMIIDELGFGDICDDEIKRGGQSYTYDTIKAFKEQHKDSELYFVIGTDQYNQLEKWYQIEYLKEMVTFVVVNRDKNSQNVENAMIAIQIPRVDISSTMIRQRVSEGKSIQVLVPKSVENYIKGEGLYEH

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Crispr_ID: NC_017340_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017340_8

2087642-2087723

Orphan

Consensus_repeat	Method
GGCCCCCACCCCAACTTACATTGT	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NC_017340_8

>merge|NC_017340|8|2087642-2087723|CRISPRCasFinder
GGCCCCCACCCCAACTTACATTGTTTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCCCACCCCAACTTGCATTGT

>NC_017340|8|7|2087642-2087723|CRISPRCasFinder
GGCCCCCACCCCAACTTACATTGT	TTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGG
GGCCCCCACCCCAACTTGCATTGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017340.1\|WP_000694772.1\|2079931_2080114_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_001558608.1\|2080213_2081197_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NC_017340.1\|WP_000759682.1\|2078448_2079381_+\|ATP-dependent-helicase	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235735
NC_017340.1\|WP_000857180.1\|2081512_2082550_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NC_017340.1\|WP_000427213.1\|2081207_2081450_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_001105696.1\|2096828_2097392_+\|accessory-gene-regulator-ArgB-like-protein	unknown	unknown	gnl\|CDD\|226899
NC_017340.1\|WP_000917289.1\|2091403_2091688_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NC_017340.1\|WP_001549197.1\|2096458_2096593_-\|delta-lysin-family-phenol-soluble-modulin	unknown	unknown	gnl\|CDD\|173213
NC_017340.1\|WP_000595392.1\|2083668_2084685_-\|bi-component-leukocidin-LukGH-subunit-G	unknown	unknown	gnl\|CDD\|369625
NC_017340.1\|WP_000206625.1\|2086197_2087421_+\|ArgE/DapE-family-deacylase	unknown	unknown	gnl\|CDD\|181490
NC_017340.1\|WP_000120297.1\|2092630_2093890_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236768
NC_017340.1\|WP_000522381.1\|2094086_2094713_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|226090
NC_017340.1\|WP_000591749.1\|2079386_2079728_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_001045079.1\|2087864_2089172_+\|TrkH-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|273349
NC_017340.1\|WP_000791411.1\|2084706_2085762_-\|bi-component-leukocidin-LukGH-subunit-H	unknown	unknown	gnl\|CDD\|369625
NC_017340.1\|WP_000240655.1\|2089711_2091328_-\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NC_017340.1\|WP_000867951.1\|2095073_2095859_+\|carbon-nitrogen-family-hydrolase	unknown	unknown	gnl\|CDD\|143607
NC_017340.1\|WP_000197635.1\|2091862_2092606_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_017340.1\|WP_001094921.1\|2097394_2097538_+\|cyclic-lactone-autoinducer-peptide	unknown	unknown	gnl\|CDD\|129030
NC_017340.1\|WP_001031454.1\|2077719_2078433_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225484

Protein	Function_ID	Function_description	E-value
NC_017340.1\|WP_001558608.1\|2080213_2081197_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	3.06668e-26
NC_017340.1\|WP_000759682.1\|2078448_2079381_+\|ATP-dependent-helicase	gnl\|CDD\|235735	PRK06195, PRK06195, DNA polymerase III subunit epsilon; Validated.	1.68456e-42
NC_017340.1\|WP_000857180.1\|2081512_2082550_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	5.76637e-25
NC_017340.1\|WP_001105696.1\|2096828_2097392_+\|accessory-gene-regulator-ArgB-like-protein	gnl\|CDD\|226899	COG4512, AgrB, Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription].	6.65966e-71
NC_017340.1\|WP_000917289.1\|2091403_2091688_-\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	5.94304e-45
NC_017340.1\|WP_000595392.1\|2083668_2084685_-\|bi-component-leukocidin-LukGH-subunit-G	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	1.05827e-99
NC_017340.1\|WP_000206625.1\|2086197_2087421_+\|ArgE/DapE-family-deacylase	gnl\|CDD\|181490	PRK08588, PRK08588, succinyl-diaminopimelate desuccinylase; Reviewed.	0
NC_017340.1\|WP_000120297.1\|2092630_2093890_-\|hypothetical-protein	gnl\|CDD\|236768	PRK10819, PRK10819, transport protein TonB; Provisional.	6.51148e-10
NC_017340.1\|WP_000522381.1\|2094086_2094713_+\|nitroreductase-family-protein	gnl\|CDD\|226090	COG3560, FMR2, Predicted oxidoreductase related to nitroreductase [General function prediction only].	8.42197e-117
NC_017340.1\|WP_001549197.1\|2096458_2096593_-\|delta-lysin-family-phenol-soluble-modulin	gnl\|CDD\|173213	PRK14752, PRK14752, delta-lysin family phenol-soluble modulin.	8.25732e-15
NC_017340.1\|WP_001045079.1\|2087864_2089172_+\|TrkH-family-potassium-uptake-protein	gnl\|CDD\|273349	TIGR00933, Trk_system_potassium_uptake_protein_trkH., potassium uptake protein, TrkH family. The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds].	7.96864e-82
NC_017340.1\|WP_000791411.1\|2084706_2085762_-\|bi-component-leukocidin-LukGH-subunit-H	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	1.84035e-77
NC_017340.1\|WP_000240655.1\|2089711_2091328_-\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NC_017340.1\|WP_000867951.1\|2095073_2095859_+\|carbon-nitrogen-family-hydrolase	gnl\|CDD\|143607	cd07583, nitrilase_5, Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	5.69545e-126
NC_017340.1\|WP_000197635.1\|2091862_2092606_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.67124e-11
NC_017340.1\|WP_001094921.1\|2097394_2097538_+\|cyclic-lactone-autoinducer-peptide	gnl\|CDD\|129030	smart00794, AgrD, Staphylococcal AgrD protein. This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr.	3.13559e-15
NC_017340.1\|WP_001031454.1\|2077719_2078433_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225484	COG2932, COG2932, Predicted transcriptional regulator [Transcription].	5.17989e-24

>NC_017340.1|WP_000206625.1|2086197_2087421_+|ArgE/DapE-family-deacylase
MTTFSEKEKIQLLADIVELQTENNNEIDVCNYLKDLFDKYDIKSEILKVNEHRANIVAEIGNGSPILALSGHMDVVDAGNQDNWTYPPFQLTEKAGKLYGRGTTDMKGGLMALVITLIELKEQNQLPQGTIRLLATAGEEKEQEGAKLLADKGYLDDVDGLIIAEPTGSGIYYAHKGSMSCKVTATGKAVHSSVPFIGDNAIDTLLEFYNQFKEKYSELKKHDTKHELDVAPMFKSLIGKEISEEDANYASGLTAVCSIINGGKQFNSVPDEASLEFNVRPVPEYDNDFIESFFQNIINDVDSNKLSLDIPSNHRPVTSDKNSKLITTIKDVASSYVEQDEIFVSALVGATDASSFLGDNKDNVDLAIFGPGNPLMAHQIDEYIEKDMYLKYIDIFKEASIQYLKEK
>NC_017340.1|WP_000791411.1|2084706_2085762_-|bi-component-leukocidin-LukGH-subunit-H
MKNKKRVLIASSLSCAILLLSAATTQANSAHKDSQDQNKKEHVDKSQQKDKRNVTNKDKNSTVPDDIGKNGKITKRTETVYDEKTNILQNLQFDFIDDPTYDKNVLLVKKQGSIHSNLKFESHKEEKNSNWLKYPSEYHVDFQVKRNRKTEILDQLPKNKISTAKVDSTFSYSSGGKFDSTKGIGRTSSNSYSKTISYNQQNYDTIASGKNNNWHVHWSVIANDLKYGGEVKNRNDELLFYRNTRIATVENPELSFASKYRYPALVRSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQDILKNRPGIHYAPPILEKNKDGQRLIVTYEVDWKNKTVKVVDKYSDDNKPYKEG
>NC_017340.1|WP_000595392.1|2083668_2084685_-|bi-component-leukocidin-LukGH-subunit-G
MIKQLYKNITICSLAISTALTVFPATSYAKINSEIKAVSEKNLDGDTKMYTRTATTSDSQKNITQSLQFNFLTEPNYDKETVFIKAKGTIGSGLRILDPNGYWNSTLRWPGSYSVSIQNVDDNNNTNVTDFAPKNQDESREVKYTYGYKTGGDFSINRGGLTGNITKESNYSETISYQQPSYRTLLDQSTSHKGVGWKVEAHLINNMGHDHTRQLTNDSDNRTKSEIFSLTRNGNLWAKDNFTPKDKMPVTVSEGFNPEFLAVMSHDKKDKGKSQFVVHYKRSMDEFKIDWNRHGFWGYWSGENHVDKKEEKLSALYEVDWKTHDVKFVKVLNDNEKK
>NC_017340.1|WP_000857180.1|2081512_2082550_+|site-specific-integrase
MKTRCYDGKKWQYEFKHEGKRYRKKGFRTKREANSAGLDKLNELRSGFNIDNYITLEEYFENWIKTYKQPVVKENTYRHYRNALQHIQKHKIGKMELSKINRQVYQKFINDHSKEHAKETIRKTNGAIRSALDDALYDGLIFKNPAYKVNYKAGKPTKSEQEKFISVTEYEILKDHVRKKRTRSSLALFIMICTGCRVSGARNIKIEHINQVKNTIFIDERKTDTSPRYISIAKSDMKHIMDVISTFAISYDGYIFKEAGSIINLQAINNALKSACRVNNIPIITSHALRHTHCSYLLAKGVSIHYISKRLGHKNIAITTSVYSHLLEEKFNEEDKKTTKILESM
>NC_017340.1|WP_000427213.1|2081207_2081450_+|hypothetical-protein
MENFNYNNIKKLVLENVDIDKVKEVYKDYELLNYTIKNQTLYMNDYEVAKVSEKHLNENINNLRGTVNLDEKCILSLTYL
>NC_017340.1|WP_001558608.1|2080213_2081197_+|glycosyltransferase-family-2-protein
MKKVSVIMPTFNNGEKLHRTISSVLNQTMKSTDYELIIIDDHSNDNGETLNVIKKYKGLVRFKQLKKNSGNASVPRNTGLKMSKAEYVFFLDSDDLLHERALEDLYNYGKENNSDLIIGKYGVEGKGRSVPKAIFEKGNVAKADIIDNSIFYALSVLKMFKKSVIDKNKIKFKTFSKTAEDQLFTIEFLMNSKNYSIKTDYEYYIVVNDFESSNHLSVNKSTGNQYFATINEIYKAIYKSPIYKNQEKRHQLAGKYTTRLLRHGQKKNFANSKMKYEDKIEWLNNFSKTINKVPRDSDKYVTQIFNLKLEAIRQNDLLAVMIADKLL
>NC_017340.1|WP_000694772.1|2079931_2080114_+|hypothetical-protein
MKIKNCKIKKETIVYEVLTSGNQPFTYELPKDLSSHNARKYLEFISQKLDGDKLTKEDSL
>NC_017340.1|WP_000591749.1|2079386_2079728_+|hypothetical-protein
MIKKIFTKKHVFLVIEDENHNHSDAVFGKSILLSIYVGVNKKTNSKSGKFIYLDRSKRIVRQSDITKIESANENDVDFYNLLKKEKEIVYSKNIVDKYNLANYIIYYEVSTKE
>NC_017340.1|WP_000759682.1|2078448_2079381_+|ATP-dependent-helicase
MKKYDIAVLDFETMNEHMNSPCEVAVSLIKDLSIVKVYSSYINPPNNRYNLKNAKIHKIPEDVILKAPKYPDIYQEILYLLKESHLIIAHNALFDISVLKNTNNYYDLPVPNFMYVDSINIFRSFHAISSFKLENLCSLYDIDKEKLHSAKFDVLALSKMLISLAKNNQHYSVLKLIHYMPKQYIRFSKYSNSPTKLFDSGFQKIHMKISEINKIEVESVIPILKDKNVVFTGNFDTEKQDLMILTRKKGAYIRSDVTAKTDILVEGVQDDKYKDVNGLVSKQRKAREYVGNGAKIQFLNEEDLINLIKE
>NC_017340.1|WP_001031454.1|2077719_2078433_+|helix-turn-helix-transcriptional-regulator
MNKERNIIIAKNIRKFLNDSNMSQKKLAELINIKPSTLSDYLNLRSNPSHGVIQRIADVFEVGKSDIDTTYKDDNDITSIYNKLTPPRQENVLNYANEQLEEQNSKGDNVVDINSYKQEKTPVNVNGCVSAGVGERLHDETLFTEMVKGPIPTHDLALKVNGDSMEPMFKDGEIIFVEKTHNIKNGQIGIFIIEEEAYVKKVFVEDDRLTLVSLNKDYDDLHFYRNESVRLIGKVIL
>NC_017340.1|WP_001045079.1|2087864_2089172_+|TrkH-family-potassium-uptake-protein
MNKVHKPLYFYLMLFFSTTIIGALLLYLPFTGKKPISFLDALFIASSAFTVTGLSPVDIGSQFNILGEIVILLLIQIGGLGIVTVTLLTLVFLNRKISMKNRFLIMVTWNIDEPGGVIKLIKHLAIYSLVTELIGMICLCLSFIPKFGIGKGLFLSLFTSVSAFNNAGFALFKNNLIDYSSDPIVIITISILIIFGGIGHFVVIDFINCKKLSKLSLHSKLVLTTTSILIIIGAITFFLLEQFNTMQHMGLVEKIGNSFFQSVTTRTAGFNSIDIASINKSTALMLMLLMFIGGAPLSAAGGIKITTFAVAFIFVLNYIRKENNVSVFNKEISDKHIKLSIVTINISFLFISIITFILSIINPNISLIKLLFEVVSAFGTVGLSMNLTTEYHGITKIIIIFVMLCGKVGLLTLLRTFIPPKSPKNYRYTKGQIYL
>NC_017340.1|WP_000240655.1|2089711_2091328_-|chaperonin-GroEL
MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIELEDPYENMGAKLVREVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGIDKAVKVAVEALHENSQKVENKNEIAQVGAISAADEEIGRYISEAMEKVGNDGVITIEESNGLNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQSNRPILIVADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKAMLEDLAILTGAQVITDDLGLDLKDASIDMLGTASKVEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNSTRAAVEEGIVAGGGTALVNVYQKVSEIEAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATNEWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM
>NC_017340.1|WP_000917289.1|2091403_2091688_-|co-chaperone-GroES
MLKPIGNRVIIEKKEQEQTTKSGIVLTDSAKEKSNEGVIVAVGTGRLLNDGTRVTPEVKEGDRVVFQQYAGTEVKRDNETYLVLNEEDILAVIE
>NC_017340.1|WP_000197635.1|2091862_2092606_+|CPBP-family-intramembrane-metalloprotease
MTRLWASLLTVIIYILSQFLPLLIVKKLPFVQYSGIELTKAVIYIQLVLFLIAATTIILINLKIKNPTKLELEVKEPKKYIIPWALLGFALVMIYQMVVSIVLTQIYGGQQVSPNTEKLIIIARKIPIFIFFVSIIGPLLEEYVFRKVIFGELFNAIKGNRIVAFIIATTVSSLIFALAHNDFKFIPVYFGMGVIFSLAYVWTKRLAVPIIIHMLQNGFVVIFQLLNPEALKKATEQANFIYHIFIP
>NC_017340.1|WP_000120297.1|2092630_2093890_-|hypothetical-protein
MSYHWFKKMLLSTSILILSSSSLGLATHTVEAKDNLNGEKPTTNLNHNITSPSVNSEMNNNETGTPHESNQTGNEGTGSNSRDANPDSNNVKPDSNNQNPSTDSKPDPNNQNPSPNPKPDPDNPKPKPDPKPDPDKPKPNLDPKPDPDNPKPKPDPKPDPDKPKPNPDPKPDPDKPKPNPNPKPDPNKPNPNPSPDPDQPGDSNHSGGSKNGGTWNPNASDGSNQGQWQPNGNQGNSQNPTGNDFVSQRFLALANGAYKYNPYILNQINKLGKDYGEVTDEDIYNIIRKQNFSGNAYLNGLQQQSNYFRFQYFNPLKSERYYRNLDEQVLALITGEIGSMPDLKKPEDKPDSKQRSFEPHEKDDFTVVKKQEDNKKSASTAYSKSWLAIVCSMMVVFSIMLFLFVKRNKKKNKNESQRR
>NC_017340.1|WP_000522381.1|2094086_2094713_+|nitroreductase-family-protein
MGLFKKDKKAMTFDNAMEERRSIYNLKDSISISDDELESMIAHAVKHVPSSFNSQSTRIVLLLNDNNNKFWDNTKAILKEVMGENRDFEPTEQKIDNFKHSYGTILFYEDQDVVSGLQEQMPNYYDNFAIWSTQTNAMHQFAIWTALATKGIGASLQHYNPLVDEMTSKEFNIPKSWKLIAQMPFGDIREAAGEKTFNPVEDRFVIKK
>NC_017340.1|WP_000867951.1|2095073_2095859_+|carbon-nitrogen-family-hydrolase
MKVQIYQLPIIFGDSSKNETQITQWFEKNMNAEVDVVVLPEMWNNGYDLEHLNEKADNNLGQSFSFIKHLAEKYKVDIVAGSVSNIRNYQIFNTAFSVNKSGQLINEYDKVHLVPMLREHEFLTAGENVAEPFQLSDGTYVTQLICYDLRFPELLRYPARSGAKIAFYVAQWPMSRLQHWHSLLKARAIENNMFVIGTNSTGFDGNTEYAGHSIVINPNGDLVGELNESADILTVDLNLNEVEQQRENIPVFKSIKLDLYK
>NC_017340.1|WP_001549197.1|2096458_2096593_-|delta-lysin-family-phenol-soluble-modulin
MSCLILRIFILIKEGVISMAQDIISTIGDLVKWIIDTVNKFTKK
>NC_017340.1|WP_001105696.1|2096828_2097392_+|accessory-gene-regulator-ArgB-like-protein
MNYFDNKIDQFATYLQKRNNLDHIQFLQVRLGMQIIVGNFFKILVTYSISIFLSVFLFTLVTHLSYMLIRYNAHGAHAKSSILCYIQSILTFVFVPYFLINIDINFTYLLALSIIGLISVVIYAPAATKKQPIPIKLVKRKKYLSIIMYLLVLILSLIIHPFYAQFMLLGILVESITLLPIFFPKED
>NC_017340.1|WP_001094921.1|2097394_2097538_+|cyclic-lactone-autoinducer-peptide
MNTLVNMFFDFIIKLAKAIGIVGGVNACSSLFDEPKVPAELTNLYDK

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Crispr_ID: NC_017340_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017340_9

2219359-2219439

Orphan

Consensus_repeat	Method
CAACTTTAGTTGTTAGGGGCTCTT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_017340_9

>merge|NC_017340|9|2219359-2219439|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTACTTTTCAACTTTAGTTGTTAGGGGCTTCT

>NC_017340|9|8|2219359-2219439|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTT	ATGCATGCGCTTAGCGCAGGCGCTCCTACTTTT
CAACTTTAGTTGTTAGGGGCTTCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017340.1\|WP_000003759.1\|2216685_2217006_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_017340.1\|WP_001123303.1\|2211318_2211732_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NC_017340.1\|WP_001127960.1\|2214494_2215433_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NC_017340.1\|WP_000927371.1\|2227372_2229505_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_017340.1\|WP_001792784.1\|2220558_2220717_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000495669.1\|2218250_2219342_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000334463.1\|2223313_2225119_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_017340.1\|WP_001292149.1\|2229516_2229951_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NC_017340.1\|WP_000123398.1\|2212188_2213562_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NC_017340.1\|WP_000070866.1\|2210675_2211119_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NC_017340.1\|WP_000083807.1\|2225799_2227338_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NC_017340.1\|WP_000908182.1\|2222299_2223082_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_017340.1\|WP_000019734.1\|2217007_2217985_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NC_017340.1\|WP_000160304.1\|2209844_2210555_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_017340.1\|WP_001024095.1\|2215868_2216534_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NC_017340.1\|WP_001048259.1\|2231375_2238821_-\|DUF1542-domain-containing-protein	unknown	unknown	gnl\|CDD\|275089
NC_017340.1\|WP_000370923.1\|2221374_2222232_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NC_017340.1\|WP_000808817.1\|2214233_2214464_-\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000648723.1\|2229950_2231057_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NC_017340.1\|WP_001802298.1\|2219774_2219879_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_017340.1\|WP_000003759.1\|2216685_2217006_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
NC_017340.1\|WP_001123303.1\|2211318_2211732_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	3.14887e-46
NC_017340.1\|WP_001127960.1\|2214494_2215433_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	7.24075e-129
NC_017340.1\|WP_000927371.1\|2227372_2229505_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	4.02509e-68
NC_017340.1\|WP_000908182.1\|2222299_2223082_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.29094e-106
NC_017340.1\|WP_001292149.1\|2229516_2229951_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
NC_017340.1\|WP_000123398.1\|2212188_2213562_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	4.11455e-06
NC_017340.1\|WP_000070866.1\|2210675_2211119_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	1.22744e-67
NC_017340.1\|WP_000083807.1\|2225799_2227338_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NC_017340.1\|WP_000648723.1\|2229950_2231057_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NC_017340.1\|WP_000019734.1\|2217007_2217985_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.49165e-107
NC_017340.1\|WP_000160304.1\|2209844_2210555_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
NC_017340.1\|WP_001024095.1\|2215868_2216534_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.27122e-47
NC_017340.1\|WP_001048259.1\|2231375_2238821_-\|DUF1542-domain-containing-protein	gnl\|CDD\|275089	TIGR04263, cell_wall_surface_anchor_family_protein, SasC/Mrp/FmtB intercellular aggregation domain. This domain, about 375 amino acids long on average, occurs only in Staphylococcus and Streptococcus. It occurs as a non-repetitive N-terminal domain of LPXTG-anchored surface proteins, including SasC, Mrp, and FmtB. This region in SasC was shown to be involved in cell aggregation and biofilm formation, which may explain the methicillin resistance seen for Mrp and FmtB.	1.2997e-108
NC_017340.1\|WP_000370923.1\|2221374_2222232_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	2.39536e-58
NC_017340.1\|WP_000334463.1\|2223313_2225119_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0

>NC_017340.1|WP_000495669.1|2218250_2219342_+|hypothetical-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYAQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKDKKVVTEPKNTKVENGKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NC_017340.1|WP_000019734.1|2217007_2217985_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALVAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHVH
>NC_017340.1|WP_000003759.1|2216685_2217006_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NC_017340.1|WP_001024095.1|2215868_2216534_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFDGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGEQDIKDALTQFEIEKD
>NC_017340.1|WP_001127960.1|2214494_2215433_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>NC_017340.1|WP_000808817.1|2214233_2214464_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>NC_017340.1|WP_000123398.1|2212188_2213562_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVKKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NC_017340.1|WP_001123303.1|2211318_2211732_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIKLITALPNRTKLLGVGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NC_017340.1|WP_000070866.1|2210675_2211119_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLENAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NC_017340.1|WP_000160304.1|2209844_2210555_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NC_017340.1|WP_001802298.1|2219774_2219879_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NC_017340.1|WP_001792784.1|2220558_2220717_+|hypothetical-protein
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>NC_017340.1|WP_000370923.1|2221374_2222232_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINQLREKGYKVFLATGRSHSEIHQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQITNLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTLDVTAYTNEEDGAAKYLAKHFLAD
>NC_017340.1|WP_000908182.1|2222299_2223082_-|ABC-transporter-ATP-binding-protein
MLIQLDQIGRMKQGKTILKNISWQIAKGDKWILYGLNGAGKTTLLNILNAYEPATTGGVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEVRNEAHHLLKLVGISAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLNILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NC_017340.1|WP_000334463.1|2223313_2225119_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEDGTPVVALATQENVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>NC_017340.1|WP_000083807.1|2225799_2227338_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NC_017340.1|WP_000927371.1|2227372_2229505_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHSQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGADSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVNKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHVETKDVDGNTSFENEQTSYLTSVFEKHLSDEKSEQLLHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFIPDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NC_017340.1|WP_001292149.1|2229516_2229951_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
>NC_017340.1|WP_000648723.1|2229950_2231057_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS
>NC_017340.1|WP_001048259.1|2231375_2238821_-|DUF1542-domain-containing-protein
MNLFRQQKFSIRKFNVGIFSALIATVTFISTNPTTASAAEQNQPAQNQPAQPADANTQPNANAGAQANPAAQPANQGGQANPAGGAAQPAGQGNQADPNNAAQAQPGNQAAPANQAGQGNNQATPNNNATPANQTQPANAPAAAQPAAPVAANAQTQDPNASNTGEGSINTTLTFDDPAISTDENRQDPTVTVTDKVNGYSLINNGKIGFVNSELRRSDMFDKNNPQNYQAKGNVAALGRVNANDSTDHGNFNGITKTVNVKPDSELIINFTTMQTNSKQGATNLVIKDAKKNTELATVNVAKTGTAHLFKVPTDADRLDLQFIPDNTAVADASRITTNKDGYKYYSFIDNVGLFSGSHLYVKNRDLAPKATNNKEYTINTEIGNNGNFGASLKADQFKYEVTLPQGVTYVNDSLTTTFPNGNEDSTVLKNMTVNYDQTANKVTFTSQGVTTARGTHTKEVLFPDKSLKLSYKVNVANIDTPKNIDFNEKLTYRTASDVVINNAQPEVTLTADPFSVAVEMNKDALQQQVNSQVDNSHYTTASIAEYNKLKQQADTILNEDANHVETANRASQADIDGLVTKLQAALIDNQAAIAELDTKAQEKVTAAQQSKKVTQDEVAALVTKINNDKNNAIAEINKQITSQGVTTEKDNGIAVLEQDVITPTVKPQAKQDIIQAVTTRKQQIKKSNASLQDEKDVANDKIGKIETKAIKDIDAATTNAQVEAIKTKAINDINQTTPATTAKAAALEEFDEVVQAQIDQAPLNPDTTNEEVAEAIERINAAKVSGVKAIEATTTAQDLERVKNEEIFKIENITDSTQTKMDAYKEVRQAATARKAQNATVSNATDEEVAEANAAVDAAQTEGLHDIQVVKSQQEVADTKAKVLDKINAIQTQAKVKPAADTEVENAYNTRKQEIQNSNASTTEEKEAAYTELDAKKQEARTNLDAANTNSDVTTAKDNGIAAINQVQAATTKKSDAKAEIAQKASERKTAIEAMNDSTTEEQQAAKDKVDQAVVTANADIDNATANTDVDNAKTTNEATIAAITPDANVKPAAKQAIADKVQAQETAIDANNGSTTEEKEAAKQQVQTEKTAADAAIDAAHSNVEVEAAKNAEIAKIEAIQPATTTKDNAKQAIATKANERKTAIAQTQDITAEEIAAANADVDNAVTQANSNIEAANSQNDVDQAKTTGETSIDQVTPTVNKKATARNEITAILNNKLQEIQATPDATDEEKQAADAEANTENGKANQAISAATTNAQVDEAKANAEAAINAVTPKVVKKQAAKDEIDQLQATQTNVINNDQNATNEEKEAAIQQLATAVTDAKNNITAATDDNGVDTAKDAGKNSIQSTQPATAVKSNAKNEVDQAVTTQNQAIDNTTGATTEEKNAAKDLVLKAKEKAYQDILNAQTTNDVTQIKDQAVADIQGITADTTIKDVAKDELATKANEQKALIAQTADATTEEKEQANQQVDAQLTQGNQNIENAQSIDDVNTAKDNAIQAIDPIQASTDVKTNARAELLTEMQNKITEILNNNETTNEEKGNDIGPVRAAYEEGLNNINAATTTGDVTTAKDTAVQKVQQLHANPVKKPAGKKELDQAAADKKTQIEQTPNASQQEINDAKQEVDTELNQAKTNVDQSSTNEYVDNAVKEGKAKINAVKTFSEYKKDALAKIEDAYNAKVNEADNSNASTSSEIAEAKQKLAELKQTADQNVNQATSKDDIEVQIHNDLDNINDYTIPTGKKESATTDLYAYADQKKNNISADTNATQDEKQQAIKQVDQNVQTALENINNGVDNGDVDDALTQGKAAIDTIQVDATVKPKANQAIEAKAEDTKESIDHSDQLTAEEKTEALAMIKQITDQAKQGITDATTTAEVEKAKAQGLEAFDNIQIDSTEKQKAIEELETALDQIEAGVNVDADATTEEKEAFTNALEDILSKATEDISDQTTNAEIATVKNSALEQLKAQRINPVVKKNALEAIREVVNKQIEIIKNADADASAKEIARTDLGRYFDRFADKLDKTQTNTEVAELQNVTIPAIEAIVPQNDPDANDTNNGTDNNDATANSNANATPENTGQPNVSETTDNGKADASPTTPNNSDAATGETTVTSATDDAKDKPQANNNSSADASTNSPTMDNDVTSKPEVESTNNGTTDKPVTETDNATPAESTTNNNSTTTATNENAPTGSTATAPTTASTEAASSADSKDNASVNDSKQNAEVNNSAESQSTNGKVAQPKSENKAKAEKDGRDSTNQSMVESTTETLPSADITEPNVPSNTSKDKEESTTNQTDAGQLKSETNVASNEADKSPSKADTEVSNKPSTSASSEAKDKMTSTNVSQKDDTATADTNDTQKSVGPVANNKAKDMQTNDTQKSVGSAANNKATQNDGANASPATVSNGSHSMHQDMLNVTKPEENKANAKSDQQGKVNKPKQQAKTLPDTGMSHNDDLPYAELALGAGMAFLIRRFTKKDQQTEE

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Crispr_ID: NC_017340_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017340_10

2231680-2231765

Orphan

Consensus_repeat	Method
CCAACTGATTTTTGCGTATCATTAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017340_10

>merge|NC_017340|10|2231680-2231765|CRISPRCasFinder
CCAACTGATTTTTGCGTATCATTAGTTTGCATATCTTTAGCTTTATTGTTTGCAACTGGGCCAACTGATTTTTGCGTATCATTAGT

>NC_017340|10|9|2231680-2231765|CRISPRCasFinder
CCAACTGATTTTTGCGTATCATTAGT	TTGCATATCTTTAGCTTTATTGTTTGCAACTGGG
CCAACTGATTTTTGCGTATCATTAGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017340.1\|WP_001292149.1\|2229516_2229951_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NC_017340.1\|WP_001792784.1\|2220558_2220717_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000047255.1\|2254630_2255314_-\|hemolysin-III-family-protein	unknown	unknown	gnl\|CDD\|224191
NC_017340.1\|WP_000927371.1\|2227372_2229505_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_017340.1\|WP_000167867.1\|2242412_2243321_-\|arginase	unknown	unknown	gnl\|CDD\|212515
NC_017340.1\|WP_000908182.1\|2222299_2223082_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_017340.1\|WP_000334463.1\|2223313_2225119_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_017340.1\|WP_000521495.1\|2239098_2240454_-\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237670
NC_017340.1\|WP_000083807.1\|2225799_2227338_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NC_017340.1\|WP_000495669.1\|2218250_2219342_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000648723.1\|2229950_2231057_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NC_017340.1\|WP_001237506.1\|2253110_2254454_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_017340.1\|WP_000884735.1\|2255332_2256520_-\|UDPGP-type-1-family-protein	unknown	unknown	gnl\|CDD\|133036
NC_017340.1\|WP_000370923.1\|2221374_2222232_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NC_017340.1\|WP_000636857.1\|2252538_2253012_-\|multidrug-efflux-transporter-SepA	unknown	unknown	gnl\|CDD\|374975
NC_017340.1\|WP_001141007.1\|2250773_2252216_-\|multidrug-efflux-MFS-transporter-LmrS	unknown	unknown	gnl\|CDD\|129794
NC_017340.1\|WP_000958531.1\|2249561_2250626_-\|P-loop-NTPase	unknown	unknown	gnl\|CDD\|378455
NC_017340.1\|WP_001802298.1\|2219774_2219879_-\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000347896.1\|2241414_2242224_-\|TIGR00159-family-protein	unknown	unknown	gnl\|CDD\|224539
NC_017340.1\|WP_000894032.1\|2240480_2241413_-\|YbbR-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|227193

Protein	Function_ID	Function_description	E-value
NC_017340.1\|WP_001292149.1\|2229516_2229951_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
NC_017340.1\|WP_000521495.1\|2239098_2240454_-\|phosphoglucosamine-mutase	gnl\|CDD\|237670	PRK14316, glmM, phosphoglucosamine mutase; Provisional.	0
NC_017340.1\|WP_000927371.1\|2227372_2229505_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	4.02509e-68
NC_017340.1\|WP_000908182.1\|2222299_2223082_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.29094e-106
NC_017340.1\|WP_000167867.1\|2242412_2243321_-\|arginase	gnl\|CDD\|212515	cd09989, Arginase, Arginase family. This family includes arginase, also known as arginase-like amidino hydrolase family, and related proteins. Arginase is a binuclear Mn-dependent metalloenzyme and catalyzes hydrolysis of L-arginine to L-ornithine and urea (Arg, EC 3.5.3.1), the reaction being the fifth and final step in the urea cycle, providing the path for the disposal of nitrogenous compounds. Arginase controls cellular levels of arginine and ornithine which are involved in protein biosynthesis, and in production of creatine, polyamines, proline and nitric acid. In vertebrates, at least two isozymes have been identified: type I (ARG1) cytoplasmic or hepatic liver-type arginase and type II (ARG2) mitochondrial or non-hepatic arginase. Point mutations in human arginase ARG1 gene lead to hyperargininemia with consequent mental disorders, retarded development and early death. Hyperargininemia is associated with a several-fold increase in the activity of the mitochondrial arginase (ARG2), causing persistent ureagenesis in patients. ARG2 overexpression plays a critical role in the pathophysiology of cholesterol mediated endothelial dysfunction. Thus, arginase is a therapeutic target to treat asthma, erectile dysfunction, atherosclerosis and cancer.	9.8301e-146
NC_017340.1\|WP_000347896.1\|2241414_2242224_-\|TIGR00159-family-protein	gnl\|CDD\|224539	COG1624, COG1624, Uncharacterized conserved protein [Function unknown].	2.13611e-103
NC_017340.1\|WP_000083807.1\|2225799_2227338_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NC_017340.1\|WP_000636857.1\|2252538_2253012_-\|multidrug-efflux-transporter-SepA	gnl\|CDD\|374975	pfam17080, SepA, Multidrug Resistance efflux pump. SepA is a drug efflux protein that is involved in bacterial multidrug resistance. It is predicted to have four transmembrane domains.	3.20059e-30
NC_017340.1\|WP_000648723.1\|2229950_2231057_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NC_017340.1\|WP_001237506.1\|2253110_2254454_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.92638e-43
NC_017340.1\|WP_000884735.1\|2255332_2256520_-\|UDPGP-type-1-family-protein	gnl\|CDD\|133036	cd04193, UDPGlcNAc_PPase, UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylase (UAP) (also named GlcNAc1P uridyltransferase), catalyzes the reversible conversion of UTP and GlcNAc1 to PPi and UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc), the activated form of GlcNAc, is a key precursor of N- and O-linked glycosylations. It is essential for the synthesis of chitin (a major component of the fungal cell wall) and of the glycosylphosphatidylinositol (GPI) linker which anchors a variety of cell surface proteins to the plasma membrane. In bacteria, UDPGlcNAc represents an essential precursor for both peptidoglycan and lipopolysaccharide biosynthesis. Human UAP has two isoforms, resulting from alternative splicing of a single gene and differing by the presence or absence of 17 amino acids. UDPGlcNAc pyrophosphorylase shares significant sequence and structure conservation with UDPglucose pyrophosphorylase.	2.43588e-149
NC_017340.1\|WP_000370923.1\|2221374_2222232_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	2.39536e-58
NC_017340.1\|WP_001141007.1\|2250773_2252216_-\|multidrug-efflux-MFS-transporter-LmrS	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.85929e-81
NC_017340.1\|WP_000958531.1\|2249561_2250626_-\|P-loop-NTPase	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	6.43129e-115
NC_017340.1\|WP_000334463.1\|2223313_2225119_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_017340.1\|WP_000047255.1\|2254630_2255314_-\|hemolysin-III-family-protein	gnl\|CDD\|224191	COG1272, COG1272, Predicted membrane protein, hemolysin III homolog [General function prediction only].	2.41003e-66
NC_017340.1\|WP_000894032.1\|2240480_2241413_-\|YbbR-like-domain-containing-protein	gnl\|CDD\|227193	COG4856, COG4856, Uncharacterized protein conserved in bacteria [Function unknown].	6.26423e-118

>NC_017340.1|WP_000648723.1|2229950_2231057_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS
>NC_017340.1|WP_001292149.1|2229516_2229951_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
>NC_017340.1|WP_000927371.1|2227372_2229505_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHSQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGADSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVNKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHVETKDVDGNTSFENEQTSYLTSVFEKHLSDEKSEQLLHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFIPDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NC_017340.1|WP_000083807.1|2225799_2227338_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NC_017340.1|WP_000334463.1|2223313_2225119_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEDGTPVVALATQENVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>NC_017340.1|WP_000908182.1|2222299_2223082_-|ABC-transporter-ATP-binding-protein
MLIQLDQIGRMKQGKTILKNISWQIAKGDKWILYGLNGAGKTTLLNILNAYEPATTGGVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEVRNEAHHLLKLVGISAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLNILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NC_017340.1|WP_000370923.1|2221374_2222232_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINQLREKGYKVFLATGRSHSEIHQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQITNLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTLDVTAYTNEEDGAAKYLAKHFLAD
>NC_017340.1|WP_001792784.1|2220558_2220717_+|hypothetical-protein
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>NC_017340.1|WP_001802298.1|2219774_2219879_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NC_017340.1|WP_000495669.1|2218250_2219342_+|hypothetical-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYAQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKDKKVVTEPKNTKVENGKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NC_017340.1|WP_000521495.1|2239098_2240454_-|phosphoglucosamine-mutase
MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLESALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFKLSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIVLDGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLAFDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEGIKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKSLSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLVRVMVEAATDEDAERFAQQIADVVQDKMGLDK
>NC_017340.1|WP_000894032.1|2240480_2241413_-|YbbR-like-domain-containing-protein
MLESKWGLRFIAFLLALFFFLSVNNVFGNIFNTGNLGQKSSKTIQDVPVEILYNTKDLHLTKAPETVNVTISGPQSKIIKIENPEDLRVVIDLSNAKAGKYQEKYQVKGLADDIHYSVKPKLANITLENKVTKKMTVQPDVSQSDIDPLYKITKQEVSPQTVKVTGGEEQLNDIAYLKATFKTNKKINGDTKDVAEVTAFDKKLNKLNVSIQPNEVNLQVKVEPFSKKVKVNVKQKGSLADDKELSSIDLEDKEIEIFGSRDDLQNISEVDAEVDLDGISESTEKTVKINLPEHVTKAQPSETKAYINVK
>NC_017340.1|WP_000347896.1|2241414_2242224_-|TIGR00159-family-protein
MDFSNFFQNLSTLKIVTSILDLLIVWYVLYLLITVFKGTKAIQLLKGILVIVIGQQISMILNLTATSKLFDIVIQWGVLALIVIFQPEIRRALEQLGRGSFLKRYTSNTYSKDEEKLIQSVSKAVQYMAKRRIGALIVFEKETGLQDYIETGIAMDSNISQELLINVFIPNTPLHDGAMIIQGTKIAAAASYLPLSDSPKISKSLGTRHRAAVGISEVSDAFTVIVSEETGDISVTFDGKLRRDISNEIFEELLAEHWFGTRFQKKGVK
>NC_017340.1|WP_000167867.1|2242412_2243321_-|arginase
MTKTKAIDIIGAPSTFGQRKLGVDLGPTAIRYAGLISRLKQLDLDVYDKGDIKVPAVNIEKFHSEQKGLRNYDEIIDVNQKLNKEVSASIENNRFPLVLGGDHSIAVGSVSAISKHYNNLGVIWYDAHGDLNIPEESPSGNIHGMPLRILTGEGPKELLELNSNVIKPENIVLIGMRDLDKGERQFIKDHNIKTFTMSDIDKLGIKEVIENTIEYLKSRNVDGVHLSLDVDALDPLETPGTGTRVLGGLSYRESHFALELLHQSHLISSMDLVEVNPLIDSNNHTAEQAVSLVGTFFGETLL
>NC_017340.1|WP_000958531.1|2249561_2250626_-|P-loop-NTPase
MLTVDQVKELVGEIKDPIIDVPLKETEGIVEVSIKEEKEHVSVKLAMAQLGGAPQLDLQMAVVNALKENGAKTVGIRFETLPEEKVNQFKPKEENKPKTIEGLLSQNNPVEFIAIASGKGGVGKSTVAVNLAVALAREGKKVGLVDADIYGFSVPDMMGIDEKPGIKGKEVIPVERHGVKVISMAFFVEENAPVIWRGPMLGKMLTNFFTEVKWGDIEYLILDLPPGTGDVALDVHTMLPSSKEIIVTTPHPTAAFVAARAGAMAKHTDHSILGVIENMSYFESKETGNKEYVFGKGGGTKLADELNTQLLGELPLEQPSWNPKDFAPSIYQSDDRLGKIYSSIAQKVIAATNK
>NC_017340.1|WP_001141007.1|2250773_2252216_-|multidrug-efflux-MFS-transporter-LmrS
MAKVELTTRRRNFIVAVMLISAFVAILNQTLLNTALPSIMRELNINESTSQWLVTGFMLVNGVMIPLTAYLMDRIKTRPLYLAAMGTFLLGSIVAALAPNFGVLMLARVIQAMGAGVLMPLMQFTLFTLFSKEHRGFAMGLAGLVIQFAPAIGPTVTGLIIDQASWRVPFIIIVGIALVAFVFGLVSISSYNEVKYTKLDKRSVMYSTIGFGLMLYAFSSAGDLGFTSPIVIGALIISMVIIYLFIRRQFNITNVLLNLRVFKNRTFALCTISSMIIMMSMVGPALLIPLYVQNSLSLSALLSGLVIMPGAIINGIMSVFTGKFYDKYGPRPLIYTGFTILTITTIMLCFLHTDTSYTYLIVVYAIRMFSVSLLMMPINTTGINSLRNEEISHGTAIMNFGRVMAGSLGTALMVTLMSFGAKIFLSTSPSHLTATEIKQQSIAIGVDISFAFVAVLVMAAYVIALFIREPKEIESNRRKF
>NC_017340.1|WP_000636857.1|2252538_2253012_-|multidrug-efflux-transporter-SepA
MIVNYLKHKFYNLLTTMIVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMYDNLLYYGSYIIFGYFIIFAVEHLMDYFRKMLPENAYFRGATFHLISYTVATTLFYFIIHLNYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
>NC_017340.1|WP_001237506.1|2253110_2254454_-|MFS-transporter
MRLKSIITVIALILIMFMSAIESSIISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLSRFKIIYVAIAGLLLFSIGSFMCGLSTNFTMLIISRVIQGFGSGVLMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIAIILVIWTFHFPEEETVAKSKFDTKGLTLFYVFIGLIMFALLNQQLLLLNFLSFILAIVVAMCLFKVEKHVSSPFLPVVEFNRSITLVFITDLLTAICLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHRIEAKLSRKVIYLLSFTLLLVSSIIISFGIKLPVLIAFVLILAGLSFGYIYTKDSVIVQEETSPLQMKKMMSFYGLTKNLGASIGSTIMGYLYAIQSGIFGPNLHNVLSAVAVISIGLIVLWVVFFKEQSSQSKE
>NC_017340.1|WP_000047255.1|2254630_2255314_-|hemolysin-III-family-protein
MSKSTKKSNDTIVETFKDIIPLSFGEEIGNAASHGVAALLTLLVLPYAAVHSYIAHGTLASVSMSIYVISIFMMFISSTIYHSMQNETPHKYILRIIDHSMIYVAISGTYTPILLTVVGGWIGWTVFILLWGTTLWGILYKSIAVKVNQKLSLIVYLVMGWVGIILLPIIFIRTSWIFILFIFLGGVSYTIGAWFYAQKNRPYFHMIWHIFIVIASLLHLIAILYFM
>NC_017340.1|WP_000884735.1|2255332_2256520_-|UDPGP-type-1-family-protein
MLDKNQLAKYKQDHLCEYEKIMSNNEKEALEEKVASLDLDFIAKLYNDLYINKKTIDDVSAVSEVKYDIKSQMSDDEIKRLEEQGLQAIKEGQFAVLLMAGGQGTRLGYKGPKGSFEIEGVSLFELQANQLKTLNHQSGHTIQWYIMTSDINHEETLAYFEAHSYFGYDQEAIHFFKQDNIVALSEEGKLILNQQGRIMETPNGNGGVFKSLDKAGYLEEMSNNGVKYIFLNNIDNVLVKVLDPLFAGFTVEHDYDITSKTIQPKPGESVGRLVNVDCKDTVLEYSELDPEVANQFNNANIGIHAFKLGFILNAVNRELPYHLAIKNLKQLDENFGVIEQPTLKFELFYFDIFTYGTSFVTLQVPREEEFSPLKNKEGKDSVATATEDLRRMGLI

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Crispr_ID: NC_017340_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017340_11

2339722-2339802

Orphan

Consensus_repeat	Method
TCTATGTTGGGGCCCCGCCAACTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017340_11

>merge|NC_017340|11|2339722-2339802|CRISPRCasFinder
TCTATGTTGGGGCCCCGCCAACTTGCACATTATTGTAAGCTGACTTTCTGTCAGCTTCTGTGTTGGGGCCCCGCCAACTTG

>NC_017340|11|10|2339722-2339802|CRISPRCasFinder
TCTATGTTGGGGCCCCGCCAACTTG	CACATTATTGTAAGCTGACTTTCTGTCAGCT
TCTGTGTTGGGGCCCCGCCAACTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017340.1\|WP_001549681.1\|2336103_2336355_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000134526.1\|2344096_2344591_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
NC_017340.1\|WP_000503822.1\|2344592_2345099_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	unknown	unknown	gnl\|CDD\|223595
NC_017340.1\|WP_000600967.1\|2336346_2337111_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|379203
NC_017340.1\|WP_000259717.1\|2342774_2344034_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NC_017340.1\|WP_000413862.1\|2334449_2335715_-\|lipid-II:glycine-glycyltransferase-FemX	unknown	unknown	gnl\|CDD\|225224
NC_017340.1\|WP_001792132.1\|2339494_2339680_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000913024.1\|2346303_2346909_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226628
NC_017340.1\|WP_000951058.1\|2337272_2337713_+\|winged-helix-DNA-binding-protein	unknown	unknown	gnl\|CDD\|197670
NC_017340.1\|WP_000808495.1\|2341832_2342279_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|223391
NC_017340.1\|WP_000866971.1\|2341593_2341827_-\|molybdopterin-converting-factor-subunit-1	unknown	unknown	gnl\|CDD\|340452
NC_017340.1\|WP_000184404.1\|2337705_2338917_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NC_017340.1\|WP_000066900.1\|2339018_2339369_-\|HTH-type-transcriptional-regulator-SarV	unknown	unknown	gnl\|CDD\|130944
NC_017340.1\|WP_000230173.1\|2339945_2340968_-\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|274250
NC_017340.1\|WP_000592307.1\|2331165_2334333_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NC_017340.1\|WP_000076930.1\|2345129_2346134_-\|ThiF-family-adenylyltransferase	unknown	unknown	gnl\|CDD\|181084
NC_017340.1\|WP_000643986.1\|2340987_2341587_-\|molybdenum-cofactor-guanylyltransferase-MobA	unknown	unknown	gnl\|CDD\|234725
NC_017340.1\|WP_001161085.1\|2330664_2330982_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000051210.1\|2330255_2330420_+\|hypothetical-protein	unknown	unknown	unknown
NC_017340.1\|WP_000602950.1\|2342292_2342778_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	unknown	unknown	gnl\|CDD\|224677

Protein	Function_ID	Function_description	E-value
NC_017340.1\|WP_000134526.1\|2344096_2344591_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	2.93711e-97
NC_017340.1\|WP_000503822.1\|2344592_2345099_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	gnl\|CDD\|223595	COG0521, MoaB, Molybdopterin biosynthesis enzymes [Coenzyme metabolism].	2.42221e-64
NC_017340.1\|WP_000600967.1\|2336346_2337111_-\|VOC-family-protein	gnl\|CDD\|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	1.50083e-38
NC_017340.1\|WP_000259717.1\|2342774_2344034_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	4.50966e-159
NC_017340.1\|WP_000413862.1\|2334449_2335715_-\|lipid-II:glycine-glycyltransferase-FemX	gnl\|CDD\|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	1.81413e-143
NC_017340.1\|WP_000076930.1\|2345129_2346134_-\|ThiF-family-adenylyltransferase	gnl\|CDD\|181084	PRK07688, PRK07688, thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated.	6.83722e-133
NC_017340.1\|WP_000913024.1\|2346303_2346909_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226628	COG4148, ModC, ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism].	1.78595e-116
NC_017340.1\|WP_000951058.1\|2337272_2337713_+\|winged-helix-DNA-binding-protein	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.35323e-15
NC_017340.1\|WP_000808495.1\|2341832_2342279_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|223391	COG0314, MoaE, Molybdopterin converting factor, large subunit [Coenzyme metabolism].	6.99133e-58
NC_017340.1\|WP_000866971.1\|2341593_2341827_-\|molybdopterin-converting-factor-subunit-1	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	8.16473e-25
NC_017340.1\|WP_000184404.1\|2337705_2338917_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.92881e-73
NC_017340.1\|WP_000066900.1\|2339018_2339369_-\|HTH-type-transcriptional-regulator-SarV	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	2.64009e-20
NC_017340.1\|WP_000602950.1\|2342292_2342778_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	gnl\|CDD\|224677	COG1763, MobB, Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism].	9.59347e-51
NC_017340.1\|WP_000592307.1\|2331165_2334333_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NC_017340.1\|WP_000643986.1\|2340987_2341587_-\|molybdenum-cofactor-guanylyltransferase-MobA	gnl\|CDD\|234725	PRK00317, mobA, molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed.	2.15389e-66
NC_017340.1\|WP_000230173.1\|2339945_2340968_-\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|274250	TIGR02666, Cyclic_pyranopterin_monophosphate_synthase, molybdenum cofactor biosynthesis protein A, bacterial. The model for this family describes molybdenum cofactor biosynthesis protein A, or MoaA, as found in bacteria. It does not include the family of probable functional equivalent proteins from the archaea. MoaA works together with MoaC to synthesize precursor Z from guanine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin].	1.0538e-165

>NC_017340.1|WP_001792132.1|2339494_2339680_+|hypothetical-protein
MFRFISFGQLVVYSTTFIPKKDILQLNDLECDINVKEPLKINYVVIFGSGTEITFSQNLFR
>NC_017340.1|WP_000066900.1|2339018_2339369_-|HTH-type-transcriptional-regulator-SarV
MSNKVQRFIEAERELSQLKHWLKTTHKISIEEFVVLFKVYEAEKISGKELRDTLHFEMLWDTSKIDVIIRKIYKKELISKLRSETDERQVFYFYSTSQKKLLDKITKEIEVLSVTN
>NC_017340.1|WP_000184404.1|2337705_2338917_+|MFS-transporter
MTNQGSLNKSPIFTKSFTINFFVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLFIVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAVVTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILGILGLIISLFIKVDFEVTNNKTETDVINKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILTYLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCLISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPSFLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
>NC_017340.1|WP_000951058.1|2337272_2337713_+|winged-helix-DNA-binding-protein
MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEKPTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNISQDQMQETINVMNQIHEILLKEAHND
>NC_017340.1|WP_000600967.1|2336346_2337111_-|VOC-family-protein
MILKFDHIIHYIDQLDRFSFPGDVIKLHSGGYHHKYGTFNKLGYINENYIELLDVENNEKLKKMAKTIEGGVAFATQIVQEKYEQGFKNICLRTNDIEAVKNKLQSEQVEVVGPIQMERDTHKDGKVKWQLLYIMNQDDDEIKPPFFIQWEESDSMRTKKLQKYFQKQFSIETVIVKSKNRSQTVSNWLKWFDMDIVEENDHYTDLILKNDDIYFRIEDGKVSKYHSVIIKDAQATSPYSIFIRGAIYRFEPLV
>NC_017340.1|WP_001549681.1|2336103_2336355_+|hypothetical-protein
MRTIILSLFIIMNIVAIIMTLSQPLTVNYFSLRVILIFFTFILSIFFILIKSSRLNNILTILSIVLVIIHMGILAHSTYVYLY
>NC_017340.1|WP_000413862.1|2334449_2335715_-|lipid-II:glycine-glycyltransferase-FemX
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEVQGVAQLLFKKVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIAKVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYILNQPLYQLIEQVKPRLTKAKIKISRKLKRK
>NC_017340.1|WP_000592307.1|2331165_2334333_-|efflux-RND-transporter-permease-subunit
MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIKFKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIPLTLAGGQGQSQSQSDNKQNSAMSDVNQASPQQNSKASAPNNISGMPTAKLGDLADITVGDVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFVDENKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGVVSTTYKKVLHWSLNHKWIVIILSTLILVATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSSPVDPTGSTNSMAIMVEYDNDTPNFDVEADKVIKHVDGFKHPGEWKNQDLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKRFTKR
>NC_017340.1|WP_001161085.1|2330664_2330982_+|hypothetical-protein
MQFYLILLAILYLIVSFISIFKMEVVFTRILRIIMGVLLLFVLALTTMSFPKENWWVFIVLLLLVGNVEVTGFKMLKKDLKGVNILNLMSLFIFVIYFILTIVLF
>NC_017340.1|WP_000051210.1|2330255_2330420_+|hypothetical-protein
MSLENQLAELKYDYVRLQGDLEKRESLNLDTSALVRQLKDIENEIRNVRAQMQD
>NC_017340.1|WP_000230173.1|2339945_2340968_-|GTP-3',8-cyclase-MoaA
MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
>NC_017340.1|WP_000643986.1|2340987_2341587_-|molybdenum-cofactor-guanylyltransferase-MobA
MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYPNVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIENHLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNIYHELSTDYLDVRDVDAPSYWYKNINYQHDLDALIQKL
>NC_017340.1|WP_000866971.1|2341593_2341827_-|molybdopterin-converting-factor-subunit-1
MKVLYFAEIKDILQKAQEDIVLEQALTVQQFEDLLFERYPQINNKKFQVAVNEEFVQKSDFIQPNDTVALIPPVSGG
>NC_017340.1|WP_000808495.1|2341832_2342279_-|molybdenum-cofactor-biosynthesis-protein-MoaE
MKQFEIVIEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE
>NC_017340.1|WP_000602950.1|2342292_2342778_-|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B
MILQIVGYKKSGKTTLMRHIVSFLKTHGYTVATIKHHGHAKEDIQLQDSDVDHMKHFEAGADQSIVQGFQYQQTVTRVDNQNLTQIIEKSVTIDTNIVLVEGFKNADFEKVVVYRDEEELQVLQQLSNVCYSINVREHEDFTAFEQWLLNKIKNDCDTQLT
>NC_017340.1|WP_000259717.1|2342774_2344034_-|molybdopterin-molybdotransferase-MoeA
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETKTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQKDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
>NC_017340.1|WP_000134526.1|2344096_2344591_+|cyclic-pyranopterin-monophosphate-synthase-MoaC
MTEFTHINQQGHAKMVDVSDKQITKRTAVAHSSITVNETIFKQISNNTNTKGNVLNTAQIAGIMAAKNTSTIIPMCHPLPLTGIDVHFSWDETNAPLYTLNIQTTVSTTGKTGVEMEALTAASATALTIYDMTKAVDKGMIIGETYLESKSGGKSGDFQRQSGQ
>NC_017340.1|WP_000503822.1|2344592_2345099_-|molybdenum-cofactor-biosynthesis-protein-MoaB
MGEHQNVKLNRTVKAAVLTVSDTRDFVTDKGGQCVRQLLQADDVEVSDAHYTIVKDEKVAITTQVKKWLEEDIDVIITTGGTGIAQRDVTIEAVKPLLTKEIEGFGELFRYLSYVEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIKPELNHLIHELTK
>NC_017340.1|WP_000076930.1|2345129_2346134_-|ThiF-family-adenylyltransferase
MSQERYSRQILFKQIGEIGQSKINQKCALIIGMGALGTHVAEGLVRAGIAKLIIVDRDYIEFSNLQRQTLFTEEDALKMMPKVVAAKKHLLALRSDVDIDGCIAHVDYYFLETHGQDVDVIIDATDNFETRQLINDFAYKHRIPWIYGGVVQSTYTEAAFIPGKTPCFNCLVPQLPALNLTCDTVGVIQPAVTMATSLQLRDAMKVLTEQPIDTKITYGDIWEGSHYSFGFSKMQRSDCTTCGDVPSYPYLNKNEQRYATLCGRDTVQYENASITHDILVQFLKQHQLNYRSNSYMVMFEFKGHRIVAFKGGRFLIHGMTRTSDATHLMNLLFG
>NC_017340.1|WP_000913024.1|2346303_2346909_-|ATP-binding-cassette-domain-containing-protein
MLKINVKYQLKNTLIRINIDDTEPKIYAVRGPSGIGKTTVLNMIAGLRKADEAIIEVNGQLLTDTTKNVNVKIQQRRIGYLFQDYQLFPNMTVYKNITFMAEPSKHIDQLIQTLNINHLMKQYPMTLSGGEAQRVALARALSTKPDLILLDEPFSSLDDTTKDESITLVKRIFNEWQIPIIFVTHSNYEAEQMAHEIITIG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_017340_1	1.1\|187578\|33\|NC_017340\|CRISPRCasFinder	187578-187610	33	NC_017340.1	1383416-1383448	0	1.0
NC_017340_4	4.1\|815772\|31\|NC_017340\|CRISPRCasFinder	815772-815802	31	NC_017340.1	310749-310779	0	1.0
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	187539-187560	0	1.0
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	310674-310695	0	1.0
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	310784-310805	0	1.0
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	649336-649357	0	1.0
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	773842-773863	0	1.0
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	864559-864580	0	1.0
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	1383319-1383340	0	1.0
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	1471872-1471893	0	1.0
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	1653211-1653232	0	1.0
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	1667745-1667766	0	1.0
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	1985119-1985140	0	1.0
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	187539-187560	0	1.0
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	310674-310695	0	1.0
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	310784-310805	0	1.0
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	649336-649357	0	1.0
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	773842-773863	0	1.0
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	864559-864580	0	1.0
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	1383319-1383340	0	1.0
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	1471872-1471893	0	1.0
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	1653211-1653232	0	1.0
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	1667745-1667766	0	1.0
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	1985119-1985140	0	1.0
NC_017340_8	8.1\|2087666\|34\|NC_017340\|CRISPRCasFinder	2087666-2087699	34	NC_017340.1	815747-815780	0	1.0
NC_017340_8	8.1\|2087666\|34\|NC_017340\|CRISPRCasFinder	2087666-2087699	34	NC_017340.1	1171673-1171706	0	1.0
NC_017340_4	4.1\|815772\|31\|NC_017340\|CRISPRCasFinder	815772-815802	31	NC_017340.1	310694-310724	1	0.968
NC_017340_4	4.1\|815772\|31\|NC_017340\|CRISPRCasFinder	815772-815802	31	NC_017340.1	1687617-1687647	1	0.968
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	978836-978857	1	0.955
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	1687472-1687493	1	0.955
NC_017340_5	5.1\|821239\|22\|NC_017340\|CRT	821239-821260	22	NC_017340.1	1687705-1687726	1	0.955
NC_017340_5	5.2\|821297\|23\|NC_017340\|CRT	821297-821319	23	NC_017340.1	774792-774814	1	0.957
NC_017340_5	5.2\|821297\|23\|NC_017340\|CRT	821297-821319	23	NC_017340.1	775070-775092	1	0.957
NC_017340_5	5.2\|821297\|23\|NC_017340\|CRT	821297-821319	23	NC_017340.1	1383435-1383457	1	0.957
NC_017340_5	5.2\|821297\|23\|NC_017340\|CRT	821297-821319	23	NC_017340.1	1985177-1985199	1	0.957
NC_017340_5	5.2\|821297\|23\|NC_017340\|CRT	821297-821319	23	NC_017340.1	2328893-2328915	1	0.957
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	978836-978857	1	0.955
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	1687472-1687493	1	0.955
NC_017340_5	5.3\|821356\|22\|NC_017340\|CRT	821356-821377	22	NC_017340.1	1687705-1687726	1	0.955
NC_017340_5	5.4\|821414\|23\|NC_017340\|CRT	821414-821436	23	NC_017340.1	774792-774814	1	0.957
NC_017340_5	5.4\|821414\|23\|NC_017340\|CRT	821414-821436	23	NC_017340.1	775070-775092	1	0.957
NC_017340_5	5.4\|821414\|23\|NC_017340\|CRT	821414-821436	23	NC_017340.1	1383435-1383457	1	0.957
NC_017340_5	5.4\|821414\|23\|NC_017340\|CRT	821414-821436	23	NC_017340.1	1985177-1985199	1	0.957
NC_017340_5	5.4\|821414\|23\|NC_017340\|CRT	821414-821436	23	NC_017340.1	2328893-2328915	1	0.957
NC_017340_6	6.1\|864510\|34\|NC_017340\|CRISPRCasFinder	864510-864543	34	NC_017340.1	1383415-1383448	1	0.971
NC_017340_7	7.1\|1653161\|33\|NC_017340\|CRISPRCasFinder	1653161-1653193	33	NC_017340.1	1383416-1383448	1	0.97
NC_017340_8	8.1\|2087666\|34\|NC_017340\|CRISPRCasFinder	2087666-2087699	34	NC_017340.1	1779870-1779903	1	0.971
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	828491-828521	1	0.968
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	828547-828577	1	0.968
NC_017340_1	1.1\|187578\|33\|NC_017340\|CRISPRCasFinder	187578-187610	33	NC_017340.1	1471764-1471796	2	0.939
NC_017340_5	5.2\|821297\|23\|NC_017340\|CRT	821297-821319	23	NC_017340.1	1471755-1471777	2	0.913
NC_017340_5	5.2\|821297\|23\|NC_017340\|CRT	821297-821319	23	NC_017340.1	2087723-2087745	2	0.913
NC_017340_5	5.4\|821414\|23\|NC_017340\|CRT	821414-821436	23	NC_017340.1	1471755-1471777	2	0.913
NC_017340_5	5.4\|821414\|23\|NC_017340\|CRT	821414-821436	23	NC_017340.1	2087723-2087745	2	0.913
NC_017340_8	8.1\|2087666\|34\|NC_017340\|CRISPRCasFinder	2087666-2087699	34	NC_017340.1	1387789-1387822	2	0.941
NC_017340_8	8.1\|2087666\|34\|NC_017340\|CRISPRCasFinder	2087666-2087699	34	NC_017340.1	2780741-2780774	2	0.941
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	88943-88973	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	387081-387111	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	649391-649421	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	828603-828633	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	864822-864852	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	1074816-1074846	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	1177274-1177304	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	1383374-1383404	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	1471808-1471838	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	1471924-1471954	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	1667799-1667829	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	1983771-1983801	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	2328946-2328976	2	0.935
NC_017340_11	11.1\|2339747\|31\|NC_017340\|CRISPRCasFinder	2339747-2339777	31	NC_017340.1	2504467-2504497	2	0.935

1. spacer 1.1|187578|33|NC_017340|CRISPRCasFinder matches to position: 1383416-1383448, mismatch: 0, identity: 1.0

tgggccccaacaaagagaaattggattcccaat	CRISPR spacer
tgggccccaacaaagagaaattggattcccaat	Protospacer
*********************************

2. spacer 4.1|815772|31|NC_017340|CRISPRCasFinder matches to position: 310749-310779, mismatch: 0, identity: 1.0

ctgtgttggggccccgccaacttgcattgcc	CRISPR spacer
ctgtgttggggccccgccaacttgcattgcc	Protospacer
*******************************

3. spacer 5.1|821239|22|NC_017340|CRT matches to position: 187539-187560, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

4. spacer 5.1|821239|22|NC_017340|CRT matches to position: 310674-310695, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

5. spacer 5.1|821239|22|NC_017340|CRT matches to position: 310784-310805, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

6. spacer 5.1|821239|22|NC_017340|CRT matches to position: 649336-649357, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

7. spacer 5.1|821239|22|NC_017340|CRT matches to position: 773842-773863, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

8. spacer 5.1|821239|22|NC_017340|CRT matches to position: 864559-864580, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

9. spacer 5.1|821239|22|NC_017340|CRT matches to position: 1383319-1383340, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

10. spacer 5.1|821239|22|NC_017340|CRT matches to position: 1471872-1471893, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

11. spacer 5.1|821239|22|NC_017340|CRT matches to position: 1653211-1653232, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

12. spacer 5.1|821239|22|NC_017340|CRT matches to position: 1667745-1667766, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

13. spacer 5.1|821239|22|NC_017340|CRT matches to position: 1985119-1985140, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

14. spacer 5.3|821356|22|NC_017340|CRT matches to position: 187539-187560, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

15. spacer 5.3|821356|22|NC_017340|CRT matches to position: 310674-310695, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

16. spacer 5.3|821356|22|NC_017340|CRT matches to position: 310784-310805, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

17. spacer 5.3|821356|22|NC_017340|CRT matches to position: 649336-649357, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

18. spacer 5.3|821356|22|NC_017340|CRT matches to position: 773842-773863, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

19. spacer 5.3|821356|22|NC_017340|CRT matches to position: 864559-864580, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

20. spacer 5.3|821356|22|NC_017340|CRT matches to position: 1383319-1383340, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

21. spacer 5.3|821356|22|NC_017340|CRT matches to position: 1471872-1471893, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

22. spacer 5.3|821356|22|NC_017340|CRT matches to position: 1653211-1653232, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

23. spacer 5.3|821356|22|NC_017340|CRT matches to position: 1667745-1667766, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

24. spacer 5.3|821356|22|NC_017340|CRT matches to position: 1985119-1985140, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

25. spacer 8.1|2087666|34|NC_017340|CRISPRCasFinder matches to position: 815747-815780, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

26. spacer 8.1|2087666|34|NC_017340|CRISPRCasFinder matches to position: 1171673-1171706, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

27. spacer 4.1|815772|31|NC_017340|CRISPRCasFinder matches to position: 310694-310724, mismatch: 1, identity: 0.968

ctgtgttggggccccgccaacttgcattgcc	CRISPR spacer
ctgtgttggggccccgccaacttgcattacc	Protospacer
****************************.**

28. spacer 4.1|815772|31|NC_017340|CRISPRCasFinder matches to position: 1687617-1687647, mismatch: 1, identity: 0.968

ctgtgttggggccccgccaacttgcattgcc	CRISPR spacer
ctgtgttggggccccgccaacttccattgcc	Protospacer
*********************** *******

29. spacer 5.1|821239|22|NC_017340|CRT matches to position: 978836-978857, mismatch: 1, identity: 0.955

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttagaaa	Protospacer
***************** ****

30. spacer 5.1|821239|22|NC_017340|CRT matches to position: 1687472-1687493, mismatch: 1, identity: 0.955

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttctttacgaaa	Protospacer
**************** *****

31. spacer 5.1|821239|22|NC_017340|CRT matches to position: 1687705-1687726, mismatch: 1, identity: 0.955

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttctttacgaaa	Protospacer
**************** *****

32. spacer 5.2|821297|23|NC_017340|CRT matches to position: 774792-774814, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

33. spacer 5.2|821297|23|NC_017340|CRT matches to position: 775070-775092, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

34. spacer 5.2|821297|23|NC_017340|CRT matches to position: 1383435-1383457, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

35. spacer 5.2|821297|23|NC_017340|CRT matches to position: 1985177-1985199, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

36. spacer 5.2|821297|23|NC_017340|CRT matches to position: 2328893-2328915, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

37. spacer 5.3|821356|22|NC_017340|CRT matches to position: 978836-978857, mismatch: 1, identity: 0.955

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttagaaa	Protospacer
***************** ****

38. spacer 5.3|821356|22|NC_017340|CRT matches to position: 1687472-1687493, mismatch: 1, identity: 0.955

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttctttacgaaa	Protospacer
**************** *****

39. spacer 5.3|821356|22|NC_017340|CRT matches to position: 1687705-1687726, mismatch: 1, identity: 0.955

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttctttacgaaa	Protospacer
**************** *****

40. spacer 5.4|821414|23|NC_017340|CRT matches to position: 774792-774814, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

41. spacer 5.4|821414|23|NC_017340|CRT matches to position: 775070-775092, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

42. spacer 5.4|821414|23|NC_017340|CRT matches to position: 1383435-1383457, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

43. spacer 5.4|821414|23|NC_017340|CRT matches to position: 1985177-1985199, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

44. spacer 5.4|821414|23|NC_017340|CRT matches to position: 2328893-2328915, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

45. spacer 6.1|864510|34|NC_017340|CRISPRCasFinder matches to position: 1383415-1383448, mismatch: 1, identity: 0.971

attgagaatccaatttctctttgttggggcccat	CRISPR spacer
attgggaatccaatttctctttgttggggcccat	Protospacer
****.*****************************

46. spacer 7.1|1653161|33|NC_017340|CRISPRCasFinder matches to position: 1383416-1383448, mismatch: 1, identity: 0.97

attgggaatccaatttctctgtgttggggccca	CRISPR spacer
attgggaatccaatttctctttgttggggccca	Protospacer
******************** ************

47. spacer 8.1|2087666|34|NC_017340|CRISPRCasFinder matches to position: 1779870-1779903, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctttgtgttgg	Protospacer
*************************.********

48. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 828491-828521, mismatch: 1, identity: 0.968

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgtcagct	Protospacer
***********************.*******

49. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 828547-828577, mismatch: 1, identity: 0.968

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgtcagct	Protospacer
***********************.*******

50. spacer 1.1|187578|33|NC_017340|CRISPRCasFinder matches to position: 1471764-1471796, mismatch: 2, identity: 0.939

tgggccccaacaaagagaaattggattcccaat	CRISPR spacer
tggaccccaacaaagagaaattgtattcccaat	Protospacer
***.******************* *********

51. spacer 5.2|821297|23|NC_017340|CRT matches to position: 1471755-1471777, mismatch: 2, identity: 0.913

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatacaat	Protospacer
**************.*** ****

52. spacer 5.2|821297|23|NC_017340|CRT matches to position: 2087723-2087745, mismatch: 2, identity: 0.913

tctgtagaaattggaaatccaat	CRISPR spacer
tctgttgaaattgggaatccaat	Protospacer
***** ********.********

53. spacer 5.4|821414|23|NC_017340|CRT matches to position: 1471755-1471777, mismatch: 2, identity: 0.913

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatacaat	Protospacer
**************.*** ****

54. spacer 5.4|821414|23|NC_017340|CRT matches to position: 2087723-2087745, mismatch: 2, identity: 0.913

tctgtagaaattggaaatccaat	CRISPR spacer
tctgttgaaattgggaatccaat	Protospacer
***** ********.********

55. spacer 8.1|2087666|34|NC_017340|CRISPRCasFinder matches to position: 1387789-1387822, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtggaatttcttatcgaaattctctgtgttgg	Protospacer
****.********* *******************

56. spacer 8.1|2087666|34|NC_017340|CRISPRCasFinder matches to position: 2780741-2780774, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctttttgttgg	Protospacer
*************************.* ******

57. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 88943-88973, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

58. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 387081-387111, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

59. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 649391-649421, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

60. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 828603-828633, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

61. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 864822-864852, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

62. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 1074816-1074846, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

63. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 1177274-1177304, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

64. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 1383374-1383404, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

65. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 1471808-1471838, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

66. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 1471924-1471954, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

67. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 1667799-1667829, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

68. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 1983771-1983801, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

69. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 2328946-2328976, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

70. spacer 11.1|2339747|31|NC_017340|CRISPRCasFinder matches to position: 2504467-2504497, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_017340_5	5.2\|821297\|23\|NC_017340\|CRT	821297-821319	23	AP014226	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S44-C3, * SEQUENCING IN PROGRESS *	28490-28512	3	0.87
NC_017340_5	5.2\|821297\|23\|NC_017340\|CRT	821297-821319	23	AP014225	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S41-C89, * SEQUENCING IN PROGRESS *	24653-24675	3	0.87
NC_017340_5	5.4\|821414\|23\|NC_017340\|CRT	821414-821436	23	AP014226	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S44-C3, * SEQUENCING IN PROGRESS *	28490-28512	3	0.87
NC_017340_5	5.4\|821414\|23\|NC_017340\|CRT	821414-821436	23	AP014225	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S41-C89, * SEQUENCING IN PROGRESS *	24653-24675	3	0.87
NC_017340_10	10.1\|2231706\|34\|NC_017340\|CRISPRCasFinder	2231706-2231739	34	JN882286	Cronobacter phage vB_CsaP_GAP52, complete genome	23034-23067	8	0.765
NC_017340_10	10.1\|2231706\|34\|NC_017340\|CRISPRCasFinder	2231706-2231739	34	CP030544	Staphylococcus aureus strain ER04166.3 plasmid unnamed2, complete sequence	7567-7600	8	0.765

1. spacer 5.2|821297|23|NC_017340|CRT matches to AP014226 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S44-C3, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 3, identity: 0.87

tctgtagaaattggaaatccaat	CRISPR spacer
actgtagaaaatggaaatccaac	Protospacer
 ********* ***********.

2. spacer 5.2|821297|23|NC_017340|CRT matches to AP014225 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S41-C89, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 3, identity: 0.87

tctgtagaaattggaaatccaat	CRISPR spacer
actgtagaaaatggaaatccaac	Protospacer
 ********* ***********.

3. spacer 5.4|821414|23|NC_017340|CRT matches to AP014226 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S44-C3, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 3, identity: 0.87

tctgtagaaattggaaatccaat	CRISPR spacer
actgtagaaaatggaaatccaac	Protospacer
 ********* ***********.

4. spacer 5.4|821414|23|NC_017340|CRT matches to AP014225 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S41-C89, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 3, identity: 0.87

tctgtagaaattggaaatccaat	CRISPR spacer
actgtagaaaatggaaatccaac	Protospacer
 ********* ***********.

5. spacer 10.1|2231706|34|NC_017340|CRISPRCasFinder matches to JN882286 (Cronobacter phage vB_CsaP_GAP52, complete genome) position: , mismatch: 8, identity: 0.765

ttgcatatctttagctttattgtttgcaactggg	CRISPR spacer
ttgcatatctttagctttatagcttttatatgct	Protospacer
******************** *.** .*  **

6. spacer 10.1|2231706|34|NC_017340|CRISPRCasFinder matches to CP030544 (Staphylococcus aureus strain ER04166.3 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.765

ttgcatatctttagctttattgtttgcaactggg	CRISPR spacer
ttgaataactttagctttattgttataaacagta	Protospacer
*** *** ****************   *** * .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

752920 : 760741

Hokovirus(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244415.1\|752920_753976_-	two-component system sensor histidine kinase SaeS	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_000149344.1\|753975_754662_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037807.1\|754636_755110_-	DoxX family protein	NA	NA	NA	NA
WP_001093562.1\|755452_755893_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000604990.1\|756172_756757_-	hypothetical protein	NA	NA	NA	NA
WP_001062972.1\|756855_757569_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941336.1\|757572_757992_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446724.1\|757993_758662_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000604514.1\|759012_759606_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	4.4e-38	42.9
WP_001217796.1\|759589_760741_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	6.0e-23	35.7

DBSCAN-SWA_2

772712 : 787353

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663030.1\|772712_773771_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	7.9e-22	26.7
WP_000197262.1\|774109_774652_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429006.1\|775530_776448_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	2.1e-07	22.0
WP_031760357.1\|776538_776640_+	hypothetical protein	NA	NA	NA	NA
WP_000193751.1\|776717_778223_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930014.1\|778563_779064_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	5.9e-52	71.5
WP_001068501.1\|779083_779950_-	DMT family transporter	NA	NA	NA	NA
WP_000692521.1\|780750_781149_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_000855514.1\|781111_783217_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|783334_784306_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000499195.1\|784486_784642_+	hypothetical protein	NA	NA	NA	NA
WP_000876318.1\|784680_785652_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.3e-139	78.9
WP_001245577.1\|785638_786595_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
WP_000616840.1\|786591_787353_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	6.5e-18	31.6

DBSCAN-SWA_3

872888 : 929776

Staphylococcus_phage(75.34%)

head,portal,tail,plate,holin,integrase,terminase,transposase,capsid

attL 870985:871001|attR 905639:905655

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
870985:871001	attL	NA	NA	NA	NA
WP_001006450.1\|872888_874139_+	cysteine desulfurase	Q2XUY6	environmental_halophage	1.1e-110	44.8
WP_001010508.1\|874128_874593_+	SUF system NifU family Fe-S cluster assembly protein	NA	NA	NA	NA
WP_001074405.1\|874743_876141_+	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
WP_001145726.1\|876208_877258_-\|integrase	site-specific integrase	A1KWY3	Staphylococcus_virus	4.5e-203	99.7
WP_000337826.1\|877370_877550_+	hypothetical protein	A0EWN7	Staphylococcus_virus	8.3e-25	100.0
WP_000392186.1\|877529_878462_-	hypothetical protein	A0EWN8	Staphylococcus_virus	3.9e-174	100.0
WP_000661437.1\|878493_879219_-	PH domain-containing protein	A0A0F6N4L7	Staphylococcus_phage	9.9e-125	100.0
WP_000775187.1\|879246_879921_-	ImmA/IrrE family metallo-endopeptidase	A0A0F6N3H6	Staphylococcus_phage	4.9e-126	100.0
WP_001055143.1\|879937_880270_-	helix-turn-helix transcriptional regulator	R4IH08	Staphylococcus_phage	4.1e-57	100.0
WP_000108122.1\|880532_880727_+	helix-turn-helix transcriptional regulator	A0A0F6N3M9	Staphylococcus_phage	1.1e-25	100.0
WP_001002757.1\|880726_881494_+	phage antirepressor Ant	A0A0F6N3N8	Staphylococcus_phage	1.1e-142	100.0
WP_000187184.1\|881494_881719_+	hypothetical protein	A0A0F6N4M2	Staphylococcus_phage	3.2e-34	100.0
WP_001094943.1\|881758_882208_+	hypothetical protein	A1KWZ2	Staphylococcus_virus	3.0e-79	100.0
WP_000977381.1\|882221_882443_+	hypothetical protein	A0A0F6N3I2	Staphylococcus_phage	1.5e-31	100.0
WP_000066011.1\|882435_882597_+	DUF1270 domain-containing protein	Q4ZAZ7	Staphylococcus_virus	2.5e-20	100.0
WP_000165363.1\|882690_882993_+	DUF2482 family protein	A0A0F6N3N3	Staphylococcus_phage	1.4e-48	100.0
WP_000291090.1\|882997_883258_+	DUF1108 family protein	Q4ZDA1	Staphylococcus_virus	1.2e-43	100.0
WP_000815401.1\|883267_883489_+	DUF2483 family protein	A7TWM6	Staphylococcus_phage	3.2e-34	100.0
WP_000139720.1\|883481_884105_+	DUF1071 domain-containing protein	A0A2H4PQQ6	Staphylococcus_phage	1.4e-114	100.0
WP_000934385.1\|884104_884533_+	single-stranded DNA-binding protein	B2ZYV4	Staphylococcus_phage	3.9e-60	100.0
WP_001124438.1\|884546_885221_+	hypothetical protein	R4IH15	Staphylococcus_phage	1.4e-125	96.9
WP_001081076.1\|885217_885367_+	hypothetical protein	A7TWN0	Staphylococcus_phage	2.4e-17	100.0
WP_000414755.1\|885359_885641_-	hypothetical protein	A0A1W6JPU7	Staphylococcus_phage	2.6e-49	100.0
WP_000190254.1\|885706_886477_+	phage protein	G4KNP0	Staphylococcus_phage	6.4e-122	100.0
WP_000803062.1\|886486_887266_+	ATP-binding protein	G4KNP1	Staphylococcus_phage	3.8e-146	100.0
WP_000256589.1\|887259_887418_+	hypothetical protein	A0A2H4PQI7	Staphylococcus_phage	4.5e-22	100.0
WP_001123695.1\|887430_887652_+	DUF3269 family protein	A0A0H3U2V4	Staphylococcus_phage	2.2e-35	100.0
WP_000049794.1\|887661_888066_+	DUF1064 domain-containing protein	A1KX76	Staphylococcus_virus	9.6e-69	100.0
WP_001187243.1\|888070_888256_+	DUF3113 family protein	A0A0F6N3K7	Staphylococcus_phage	1.1e-27	100.0
WP_000101252.1\|888256_888562_+	hypothetical protein	A0A0F6N4H9	Staphylococcus_phage	1.7e-49	100.0
WP_000029376.1\|888689_889046_+	hypothetical protein	A0A0F6N3E3	Staphylococcus_phage	6.5e-61	100.0
WP_000131376.1\|889049_889292_+	hypothetical protein	A0A0F6N3E1	Staphylococcus_phage	1.9e-40	98.8
WP_001557190.1\|889300_889672_+	hypothetical protein	A0A0F6N3K4	Staphylococcus_phage	3.6e-54	100.0
WP_001065060.1\|889664_889919_+	DUF1024 family protein	A1KX15	Staphylococcus_virus	2.5e-38	97.6
WP_000714412.1\|889905_890076_+	hypothetical protein	A7TWH6	Staphylococcus_phage	1.5e-20	91.1
WP_000185647.1\|890068_890602_+	dUTP pyrophosphatase	A1KX16	Staphylococcus_virus	2.4e-96	99.4
WP_000617154.1\|890638_890845_+	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.0e-18	72.1
WP_000132921.1\|890841_891036_+	hypothetical protein	A0A2I6PEC2	Staphylococcus_phage	6.0e-29	100.0
WP_001072795.1\|891032_891236_+	hypothetical protein	A0A0N9BAX5	Staphylococcus_phage	5.2e-31	100.0
WP_000608278.1\|891228_891465_+	hypothetical protein	Q4ZDP0	Staphylococcus_virus	2.8e-36	100.0
WP_000595257.1\|891457_891631_+	transcriptional activator RinB	Q4ZBK0	Staphylococcus_phage	6.4e-22	100.0
WP_000990004.1\|891631_891736_+	hypothetical protein	B2ZYX7	Staphylococcus_phage	7.0e-08	100.0
WP_000162701.1\|891801_892224_+	RinA family phage transcriptional activator	A0A0F6N3E5	Staphylococcus_phage	1.2e-74	100.0
WP_001038244.1\|892411_892906_+\|terminase	terminase small subunit	A0A0F6N3K6	Staphylococcus_phage	7.8e-89	100.0
WP_000273011.1\|892908_894204_+\|terminase	PBSX family phage terminase large subunit	A0A0F6N3L3	Staphylococcus_phage	3.0e-257	100.0
WP_000909970.1\|894214_895753_+\|portal	phage portal protein	A0A0F6N4I8	Staphylococcus_phage	2.4e-293	100.0
WP_001133044.1\|895759_896755_+\|capsid	minor capsid protein	A0A0F6N3F1	Staphylococcus_phage	2.0e-184	100.0
WP_000072208.1\|896827_896998_+	hypothetical protein	A0A0F6N3E9	Staphylococcus_phage	1.5e-23	100.0
WP_000392151.1\|897106_897727_+	DUF4355 domain-containing protein	S4V984	Staphylococcus_phage	1.7e-69	98.5
WP_000438511.1\|897740_898715_+\|capsid	phage major capsid protein	E0Y3L0	Staphylococcus_virus	2.2e-183	100.0
WP_001114086.1\|898736_899024_+	hypothetical protein	S4V6D9	Staphylococcus_phage	1.4e-45	98.9
WP_000208960.1\|899032_899365_+\|head,tail	phage head-tail connector protein	A0A0F6N3F4	Staphylococcus_phage	5.5e-54	100.0
WP_001268312.1\|899361_899664_+	hypothetical protein	A4ZFB6	Staphylococcus_virus	1.1e-50	100.0
WP_001017817.1\|899663_900011_+	HK97 gp10 family phage protein	A0A0F6N3F5	Staphylococcus_phage	2.0e-59	99.1
WP_000188643.1\|900022_900406_+	hypothetical protein	E0Y3L5	Staphylococcus_virus	3.8e-67	98.4
WP_000002577.1\|900424_901006_+\|tail	phage major tail protein, TP901-1 family	A0A0F6N3L8	Staphylococcus_phage	4.9e-106	100.0
WP_001100161.1\|901067_901433_+\|tail	tail assembly chaperone	A0A0F6N4J9	Staphylococcus_phage	3.6e-59	100.0
WP_000105584.1\|901462_901807_+	hypothetical protein	A0A0F6N3F7	Staphylococcus_phage	2.5e-57	100.0
WP_000141480.1\|901823_905291_+	hypothetical protein	A0A0F6N3F9	Staphylococcus_phage	4.2e-245	100.0
WP_000350675.1\|905303_906251_+\|tail	phage tail family protein	A0A0F6N3L4	Staphylococcus_phage	2.8e-183	100.0
905639:905655	attR	NA	NA	NA	NA
WP_000152714.1\|906259_908161_+\|tail	phage tail protein	I1W634	Staphylococcus_phage	0.0e+00	99.8
WP_000369017.1\|908175_910086_+	hypothetical protein	Q4ZDD6	Staphylococcus_virus	0.0e+00	98.9
WP_000259619.1\|910085_911909_+\|plate	BppU family phage baseplate upper protein	A1KX42	Staphylococcus_virus	3.9e-295	99.2
WP_000705896.1\|911908_912286_+	DUF2977 domain-containing protein	A0A0F6N3G4	Staphylococcus_phage	1.5e-60	100.0
WP_000782200.1\|912289_912463_+	XkdX family protein	A0A0F6N3L7	Staphylococcus_phage	6.6e-27	100.0
WP_000466778.1\|912502_912802_+	DUF2951 domain-containing protein	A0A0H4ITZ0	Staphylococcus_phage	7.6e-47	100.0
WP_000524022.1\|912938_914837_+	glucosaminidase domain-containing protein	A0EX80	Staphylococcus_virus	0.0e+00	99.7
WP_000276662.1\|914849_916088_+\|plate	BppU family phage baseplate upper protein	A0A0F6N3G7	Staphylococcus_phage	1.6e-210	100.0
WP_000398868.1\|916093_916489_+	hypothetical protein	A1KXB6	Staphylococcus_virus	1.6e-68	100.0
WP_000351119.1\|916544_916820_+\|holin	phage holin	A0A0F6N3M0	Staphylococcus_phage	8.6e-45	100.0
WP_001141517.1\|916806_918219_+	N-acetylmuramoyl-L-alanine amidase	A0A0F6N3N1	Staphylococcus_phage	5.8e-286	100.0
WP_001035620.1\|918278_918836_-	DUF4888 domain-containing protein	A0A0F6N4L1	Staphylococcus_phage	7.4e-96	100.0
WP_001788502.1\|919210_919363_+	hypothetical protein	A0A0F6N3H2	Staphylococcus_phage	3.1e-20	100.0
WP_000139423.1\|919433_919544_+	hypothetical protein	W5R8J7	Staphylococcus_phage	1.7e-12	100.0
WP_001286805.1\|919545_919731_+	hypothetical protein	A0A0F6N3H3	Staphylococcus_phage	2.7e-26	100.0
WP_000274029.1\|920560_920875_-	hypothetical protein	NA	NA	NA	NA
WP_000582326.1\|921239_922280_+	HlyC/CorC family transporter	NA	NA	NA	NA
WP_000267236.1\|922293_923361_+	nitronate monooxygenase	NA	NA	NA	NA
WP_016170465.1\|923571_923655_+	hypothetical protein	NA	NA	NA	NA
WP_000608129.1\|923702_924551_+	DUF72 domain-containing protein	NA	NA	NA	NA
WP_000927632.1\|924563_925391_+	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_001241246.1\|925417_926737_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_000201875.1\|926820_927738_+	lipoyl synthase	NA	NA	NA	NA
WP_000598444.1\|927867_928251_+	YutD family protein	NA	NA	NA	NA
WP_001557163.1\|928456_929776_+\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA

DBSCAN-SWA_4

1004292 : 1056306

Streptococcus_phage(33.33%)

bacteriocin,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000448934.1\|1004292_1005282_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_000258003.1\|1005575_1005971_+	transcriptional regulator Spx	NA	NA	NA	NA
WP_001217728.1\|1006341_1007061_+	adaptor protein MecA	NA	NA	NA	NA
WP_000959282.1\|1007181_1008168_+	competence protein CoiA	NA	NA	NA	NA
WP_000082725.1\|1008215_1010024_+	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	5.5e-47	24.5
WP_000896697.1\|1010483_1011290_-\|protease	protease adaptor protein YjbH	NA	NA	NA	NA
WP_000214070.1\|1011312_1011678_-	truncated hemoglobin	NA	NA	NA	NA
WP_000224619.1\|1011781_1012375_-	CYTH domain-containing protein	NA	NA	NA	NA
WP_001242103.1\|1012560_1012908_+	hypothetical protein	NA	NA	NA	NA
WP_001077683.1\|1012924_1013560_+	GTP pyrophosphokinase family protein	NA	NA	NA	NA
WP_001270834.1\|1013576_1014386_+	NAD kinase	NA	NA	NA	NA
WP_000669920.1\|1014382_1015237_+	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_000062407.1\|1015257_1016643_+	magnesium transporter	NA	NA	NA	NA
WP_000395153.1\|1016652_1018497_+	monovalent cation:proton antiporter family protein	NA	NA	NA	NA
WP_000933195.1\|1018774_1019545_+	enoyl-ACP reductase FabI	NA	NA	NA	NA
WP_000933105.1\|1019741_1020827_-	AI-2E family transporter	NA	NA	NA	NA
WP_000570687.1\|1021168_1022737_+	alanine:cation symporter family protein	NA	NA	NA	NA
WP_001288675.1\|1022881_1023640_+	esterase family protein	NA	NA	NA	NA
WP_000600387.1\|1023833_1024343_+	2'-5' RNA ligase family protein	NA	NA	NA	NA
WP_001154223.1\|1024455_1025646_-	MFS transporter	NA	NA	NA	NA
WP_000258645.1\|1025623_1026799_-	diglucosyl diacylglycerol synthase	NA	NA	NA	NA
WP_000340119.1\|1027231_1028716_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
WP_001795833.1\|1028696_1028957_+	YueH family protein	NA	NA	NA	NA
WP_001049950.1\|1028956_1030519_+	peptide chain release factor 3	A0A1S5SF82	Streptococcus_phage	1.7e-36	28.2
WP_000928413.1\|1030820_1031624_+	TerC family protein	S5MAL1	Bacillus_phage	1.6e-30	40.5
WP_001795272.1\|1031842_1034167_+\|protease	serine protease	W5SAB9	Pithovirus	2.8e-11	27.4
WP_000021865.1\|1034183_1035542_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000414165.1\|1035680_1037192_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_000287265.1\|1037678_1038248_-	competence protein ComK	NA	NA	NA	NA
WP_000876826.1\|1038457_1038676_+	IDEAL domain-containing protein	NA	NA	NA	NA
WP_000668818.1\|1038756_1039743_-	lipoate--protein ligase	NA	NA	NA	NA
WP_000214898.1\|1039941_1040118_+	YkvS family protein	NA	NA	NA	NA
WP_001033865.1\|1040132_1040735_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001792055.1\|1041650_1041752_+	hypothetical protein	NA	NA	NA	NA
WP_001797239.1\|1041761_1042034_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000870829.1\|1042077_1044042_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000668627.1\|1044044_1044365_+	YxeA family protein	NA	NA	NA	NA
WP_000571167.1\|1044361_1045003_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.7e-19	33.0
WP_001795266.1\|1045090_1045381_-	hypothetical protein	NA	NA	NA	NA
WP_001792054.1\|1045521_1045659_+	poly(glycerol-phosphate) alpha-glucosyltransferase	NA	NA	NA	NA
WP_000766008.1\|1045747_1046104_-	DoxX family protein	NA	NA	NA	NA
WP_001081351.1\|1046591_1047551_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001790177.1\|1047596_1047728_-	hypothetical protein	NA	NA	NA	NA
WP_000867357.1\|1047791_1048007_-	TM2 domain-containing protein	A0A060AN66	Enterococcus_phage	1.5e-07	49.1
WP_000620949.1\|1048171_1048723_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000070966.1\|1048774_1049713_-	1,4-dihydroxy-2-naphthoate polyprenyltransferase	NA	NA	NA	NA
WP_000190622.1\|1049894_1051256_+	isochorismate synthase MenF	NA	NA	NA	NA
WP_000526694.1\|1051242_1052916_+	2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase	NA	NA	NA	NA
WP_000150197.1\|1052902_1053706_+	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase	NA	NA	NA	NA
WP_000184945.1\|1053698_1054520_+	1,4-dihydroxy-2-naphthoyl-CoA synthase	NA	NA	NA	NA
WP_000284458.1\|1054757_1055087_-	staphostatin B	NA	NA	NA	NA
WP_001089094.1\|1055124_1056306_-\|protease	cysteine protease staphopain B	NA	NA	NA	NA

DBSCAN-SWA_5

1076326 : 1084799

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000861573.1\|1076326_1076809_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	8.0e-22	44.7
WP_001010413.1\|1076795_1077920_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174053.1\|1077923_1078628_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.3e-48	42.1
WP_000848350.1\|1078627_1078891_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666806.1\|1078892_1079564_+	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000032740.1\|1079556_1081746_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	3.5e-141	39.8
WP_000483720.1\|1081724_1083209_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.9e-45	31.7
WP_000030811.1\|1083201_1084230_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	3.4e-62	41.7
WP_000238669.1\|1084232_1084799_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.1e-29	40.1

DBSCAN-SWA_6

1702804 : 1711847

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1702804_1703323_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_000595011.1\|1703344_1705618_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	8.1e-64	29.3
WP_000749795.1\|1705820_1708100_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1708374_1708635_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1708653_1709793_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001019178.1\|1709815_1710841_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005768.1\|1710842_1711847_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_7

1841990 : 1899692

Staphylococcus_phage(95.35%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001050574.1\|1841990_1848551_-	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	2.3e-305	98.2
WP_000836461.1\|1848876_1849188_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	4.8e-52	99.0
WP_001557386.1\|1849209_1851627_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.5
WP_001025067.1\|1851914_1853096_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	7.3e-218	99.7
WP_000526539.1\|1853205_1854159_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
WP_000764419.1\|1854155_1854719_+	class I SAM-dependent methyltransferase	A0A2H4PQV0	Staphylococcus_phage	8.3e-103	99.5
WP_000757543.1\|1854841_1855243_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266096.1\|1855813_1856641_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_001790712.1\|1856643_1856763_-	hypothetical protein	NA	NA	NA	NA
WP_001196362.1\|1856874_1857876_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	2.6e-184	99.4
WP_001008549.1\|1857997_1858462_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	4.5e-70	100.0
WP_001159037.1\|1858474_1859656_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	5.6e-226	99.5
WP_000493887.1\|1859666_1860299_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	5.5e-111	98.6
WP_000077358.1\|1860305_1861349_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	5.3e-196	98.8
WP_001261668.1\|1861829_1863332_-	FAD/NAD(P)-binding protein	A0A2H4PQX2	Staphylococcus_phage	1.9e-29	98.6
WP_000221177.1\|1863854_1864169_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	9.8e-53	98.1
WP_000989121.1\|1864168_1865461_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	5.0e-228	99.5
WP_001032833.1\|1865547_1866402_-	N-acetylglucosaminidase	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1866677_1866902_-	hypothetical protein	NA	NA	NA	NA
WP_000671057.1\|1867100_1867571_+	RNA polymerase sigma factor SigS	A0A2H4PQT5	Staphylococcus_phage	8.8e-82	98.1
WP_001153742.1\|1867683_1868127_+	competence protein ComK	NA	NA	NA	NA
WP_001030469.1\|1868113_1868557_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	2.4e-57	98.6
WP_001168903.1\|1868852_1869488_+\|protease	CPBP family intramembrane metalloprotease SdpA	NA	NA	NA	NA
WP_001096494.1\|1869927_1870641_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091442.1\|1870900_1871203_+	hypothetical protein	NA	NA	NA	NA
WP_001200542.1\|1871458_1871824_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-59	100.0
WP_000623470.1\|1871820_1872174_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	3.8e-21	94.0
WP_000453306.1\|1874170_1875004_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	7.8e-158	99.3
WP_000366163.1\|1875215_1876124_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	3.4e-138	100.0
WP_000933820.1\|1876245_1877442_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	4.3e-218	99.5
WP_000109906.1\|1877813_1879406_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	100.0
WP_001822900.1\|1879783_1880530_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	1.4e-142	98.8
WP_000672013.1\|1880534_1881008_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	7.2e-84	98.7
WP_000718107.1\|1881073_1881331_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778528.1\|1881327_1882329_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	5.3e-185	97.3
WP_000348364.1\|1882333_1883812_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.8e-283	97.6
WP_012840523.1\|1883970_1884426_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	3.6e-80	99.3
WP_001795210.1\|1884728_1885379_+	excalibur calcium-binding domain-containing protein	A0A2H4PQM8	Staphylococcus_phage	2.9e-51	94.0
WP_000070642.1\|1885459_1886455_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	2.6e-67	97.9
WP_000669024.1\|1886529_1887156_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	3.1e-74	79.8
WP_000627540.1\|1887196_1887538_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	1.1e-54	94.7
WP_000414216.1\|1887638_1888211_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	2.3e-23	93.1
WP_001801861.1\|1889565_1889661_+	type I toxin-antitoxin system Fst family toxin PepA1	NA	NA	NA	NA
WP_001792025.1\|1889783_1889885_+	hypothetical protein	NA	NA	NA	NA
WP_000072627.1\|1890960_1892190_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	4.0e-134	64.7
WP_000028669.1\|1892182_1893739_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	1.6e-289	100.0
WP_001791797.1\|1893902_1894037_-	hypothetical protein	NA	NA	NA	NA
WP_001038752.1\|1894099_1894819_-\|protease	serine protease SplF	A0A2H4PQP1	Staphylococcus_phage	1.9e-131	99.6
WP_011447030.1\|1894920_1895028_+	hypothetical protein	NA	NA	NA	NA
WP_001038704.1\|1894976_1895696_-\|protease	serine protease SplD	A0A2H4PQP9	Staphylococcus_phage	4.6e-130	99.6
WP_001038872.1\|1895816_1896536_-\|protease	serine protease SplC	A0A2H4PQP7	Staphylococcus_phage	1.3e-129	98.7
WP_001039454.1\|1896593_1897316_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	3.5e-130	98.3
WP_001039427.1\|1897440_1898148_-\|protease	serine protease SplA	A0A2H4PQN3	Staphylococcus_phage	7.9e-127	97.0
WP_001092780.1\|1899110_1899692_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	9.6e-54	64.8

DBSCAN-SWA_8

2009150 : 2092606

106

Staphylococcus_phage(90.54%)

head,portal,tail,protease,holin,integrase,terminase,capsid

attL 2058926:2058943|attR 2083746:2083763

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000827746.1\|2009150_2010317_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
WP_000434933.1\|2010347_2010674_+	staphostatin A	NA	NA	NA	NA
WP_000669862.1\|2010965_2011139_-	NETI motif-containing protein	NA	NA	NA	NA
WP_000011542.1\|2011119_2011722_-	DUF2179 domain-containing protein	NA	NA	NA	NA
WP_000040866.1\|2011992_2012814_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	2.3e-69	52.7
WP_000284436.1\|2012806_2014276_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	5.9e-108	45.1
WP_000897635.1\|2014459_2015536_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
WP_001177828.1\|2015555_2016350_+	prephenate dehydratase	NA	NA	NA	NA
WP_001802312.1\|2016421_2016529_+	hypothetical protein	NA	NA	NA	NA
WP_000323161.1\|2016539_2018102_-	SLC13 family permease	NA	NA	NA	NA
WP_000275727.1\|2018306_2019404_-	pectate lyase	U5PWM6	Bacillus_phage	3.3e-47	34.6
WP_000149686.1\|2019772_2020333_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
WP_001140871.1\|2020385_2021315_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
WP_001792184.1\|2021507_2021681_-	hypothetical protein	NA	NA	NA	NA
WP_001021211.1\|2021732_2023112_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_000181315.1\|2023231_2024260_-	lactonase family protein	NA	NA	NA	NA
WP_000205106.1\|2024529_2024931_+	YolD-like family protein	U3PG23	Staphylococcus_phage	6.0e-23	42.9
WP_000267034.1\|2025503_2025677_-	hypothetical protein	NA	NA	NA	NA
WP_001188043.1\|2026127_2027168_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_000713072.1\|2027224_2028067_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_001033971.1\|2028063_2028621_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000966288.1\|2028680_2029205_-	membrane protein	NA	NA	NA	NA
WP_000182842.1\|2029325_2029889_+	thioredoxin family protein	NA	NA	NA	NA
WP_001221651.1\|2029954_2030695_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
WP_000763043.1\|2030694_2031567_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	1.0e-27	36.0
WP_000645727.1\|2031563_2032244_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
WP_000991306.1\|2032244_2033141_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	5.0e-17	30.2
WP_000691584.1\|2033137_2033518_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000681968.1\|2033775_2033952_-	hypothetical protein	NA	NA	NA	NA
WP_000990056.1\|2034194_2034293_-	hypothetical protein	NA	NA	NA	NA
WP_001068542.1\|2034492_2035779_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_000671712.1\|2036057_2036348_-	MAP domain-containing protein	NA	NA	NA	NA
WP_001557458.1\|2036362_2037793_-	extracellular adherence protein Eap/Map	NA	NA	NA	NA
WP_000669789.1\|2038750_2038930_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	2.2e-25	100.0
WP_001791826.1\|2039244_2039505_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_000702262.1\|2039557_2039908_-	complement inhibitor SCIN-A	A7TWS0	Staphylococcus_phage	7.5e-54	100.0
WP_000727645.1\|2040590_2041040_+	chemotaxis-inhibiting protein CHIPS	A0A075LZI2	Staphylococcus_phage	8.7e-79	100.0
WP_000920042.1\|2042115_2042607_-	staphylokinase	A0A075LYD3	Staphylococcus_phage	8.0e-86	100.0
WP_000861026.1\|2042797_2043553_-	CHAP domain-containing protein	A0A075LZV3	Staphylococcus_phage	1.2e-152	100.0
WP_000611512.1\|2043564_2043819_-\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
WP_031762631.1\|2043870_2043978_+	hypothetical protein	NA	NA	NA	NA
WP_011447039.1\|2044030_2044207_-\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	2.2e-22	98.3
WP_025174055.1\|2044409_2045183_-	staphylococcal enterotoxin type P	A0A075M4C7	Staphylococcus_phage	4.0e-148	99.6
WP_000340977.1\|2045603_2045978_-	hypothetical protein	G4KNR3	Staphylococcus_phage	3.3e-39	100.0
WP_001262621.1\|2046033_2046321_-	hypothetical protein	A0A1X9H0N7	Staphylococcus_phage	7.6e-44	100.0
WP_001000058.1\|2046366_2046519_-	hypothetical protein	A0A1W6JPL6	Staphylococcus_phage	7.6e-19	100.0
WP_000582152.1\|2046511_2050294_-	hypothetical protein	A0A068A201	Staphylococcus_phage	0.0e+00	99.6
WP_000567396.1\|2050309_2051794_-\|tail	phage tail family protein	A0A2I6PDJ0	Staphylococcus_phage	4.5e-297	99.8
WP_000504566.1\|2051790_2056320_-\|tail	phage tail tape measure protein	A0EX03	Staphylococcus_phage	0.0e+00	97.0
WP_001549167.1\|2056376_2056514_-	hypothetical protein	A0A2I6PDX7	Staphylococcus_phage	3.4e-18	100.0
WP_001096355.1\|2056564_2056915_-	hypothetical protein	G4KNQ8	Staphylococcus_phage	7.8e-59	100.0
WP_071621395.1\|2056964_2057189_-	Ig-like domain-containing protein	A0A075LYE8	Staphylococcus_phage	3.0e-32	100.0
WP_000268740.1\|2057230_2057875_-\|tail	phage tail protein	G4KNQ7	Staphylococcus_phage	6.5e-120	100.0
WP_000565498.1\|2057875_2058283_-	hypothetical protein	G4KNQ6	Staphylococcus_phage	7.1e-72	100.0
WP_000114226.1\|2058279_2058684_-	HK97 gp10 family phage protein	G4KNQ5	Staphylococcus_phage	4.3e-69	100.0
WP_000755150.1\|2058680_2059043_-\|head,tail	head-tail adaptor protein	G4KNQ4	Staphylococcus_phage	4.4e-65	100.0
2058926:2058943	attL	NA	NA	NA	NA
WP_000150936.1\|2059026_2059311_-\|head,tail	phage head-tail adapter protein	A0A2I6PDJ5	Staphylococcus_phage	2.3e-45	100.0
WP_000238236.1\|2059300_2059585_-	hypothetical protein	A0A2I6PDJ3	Staphylococcus_phage	1.8e-45	100.0
WP_000154559.1\|2059604_2060750_-\|capsid	phage major capsid protein	G4KNQ3	Staphylococcus_phage	9.6e-215	100.0
WP_000642728.1\|2060773_2061511_-\|protease	Clp protease ClpP	G4KNQ2	Staphylococcus_phage	1.8e-129	100.0
WP_000025274.1\|2061494_2062682_-\|portal	phage portal protein	A0A2I6PDI1	Staphylococcus_phage	1.0e-219	100.0
WP_000625088.1\|2062697_2064359_-\|terminase	terminase large subunit	A0A2I6PDJ8	Staphylococcus_phage	0.0e+00	100.0
WP_000402904.1\|2064355_2064700_-	hypothetical protein	G4KNP9	Staphylococcus_phage	9.4e-57	100.0
WP_000988332.1\|2064831_2065131_-	HNH endonuclease	A0A2I6PDH9	Staphylococcus_phage	3.5e-52	100.0
WP_000590122.1\|2065362_2065779_-	hypothetical protein	G4KNP7	Staphylococcus_phage	1.3e-76	100.0
WP_001557462.1\|2065806_2066007_-	DUF1514 family protein	D2JLD9	Staphylococcus_phage	5.3e-28	98.5
WP_000595265.1\|2066006_2066156_-	transcriptional activator RinB	A0A1W6JPZ2	Staphylococcus_phage	4.8e-18	100.0
WP_000195784.1\|2066152_2066359_-	DUF1381 domain-containing protein	A0A2I6PEA2	Staphylococcus_phage	1.1e-17	94.1
WP_001282077.1\|2066355_2066601_-	hypothetical protein	A0A2I6PDW7	Staphylococcus_phage	2.5e-35	98.8
WP_000185693.1\|2066637_2067174_-	dUTP diphosphatase	Q9MBR0	Staphylococcus_prophage	1.6e-95	100.0
WP_001065108.1\|2067170_2067416_-	DUF1024 family protein	Q8SDV5	Staphylococcus_phage	1.7e-36	95.1
WP_000178987.1\|2067430_2067679_-	hypothetical protein	A0A0K1LL46	Staphylococcus_phage	7.5e-40	96.3
WP_000111491.1\|2067675_2067933_-	DUF3310 domain-containing protein	A0A1X9H067	Staphylococcus_phage	6.3e-42	98.8
WP_000101279.1\|2067932_2068304_-	hypothetical protein	A0A2I6PDG3	Staphylococcus_phage	1.4e-50	91.1
WP_000401969.1\|2068316_2068721_-	RusA family crossover junction endodeoxyribonuclease	A0A075M042	Staphylococcus_phage	8.4e-73	100.0
WP_000338528.1\|2068729_2068948_-	hypothetical protein	A0A1P8L6E4	Staphylococcus_phage	1.4e-37	100.0
WP_000148333.1\|2068954_2069848_-	DnaD domain-containing protein	A0A1P8L6F0	Staphylococcus_phage	3.2e-141	100.0
WP_000934759.1\|2069877_2070348_-	single-stranded DNA-binding protein	A0A1P8L6D9	Staphylococcus_phage	5.7e-81	100.0
WP_064135358.1\|2070348_2070966_-	MBL fold metallo-hydrolase	A0A1P8L6F7	Staphylococcus_phage	1.2e-86	100.0
WP_000180600.1\|2071046_2071967_-	recombinase RecT	A0A1P8L6F6	Staphylococcus_phage	5.1e-166	100.0
WP_000700554.1\|2071968_2073912_-	AAA family ATPase	A0A1P8L6F1	Staphylococcus_phage	0.0e+00	100.0
WP_001205732.1\|2073920_2074184_-	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	7.7e-43	100.0
WP_000291510.1\|2074192_2074453_-	DUF1108 family protein	A0A1P8L6F5	Staphylococcus_phage	5.2e-44	100.0
WP_000165371.1\|2074457_2074760_-	DUF2482 family protein	A0A1P8L6F8	Staphylococcus_phage	7.0e-48	100.0
WP_000048129.1\|2074854_2075016_-	DUF1270 family protein	A0A1P8L6G0	Staphylococcus_phage	1.9e-20	100.0
WP_001120201.1\|2075012_2075336_-	DUF771 domain-containing protein	A0A075LYF5	Staphylococcus_phage	3.0e-57	100.0
WP_000762521.1\|2075390_2075771_+	DUF2513 domain-containing protein	Q9T1Z5	Staphylococcus_phage	1.2e-68	100.0
WP_001148856.1\|2075757_2075955_-	hypothetical protein	O80075	Staphylococcus_phage	2.5e-30	100.0
WP_001148605.1\|2075970_2076723_-	phage antirepressor KilAC domain-containing protein	M9NTH5	Staphylococcus_phage	1.1e-139	100.0
WP_000128909.1\|2076773_2077103_+	hypothetical protein	M9NS98	Staphylococcus_phage	5.1e-52	98.2
WP_001025404.1\|2077091_2077307_-	DUF2829 domain-containing protein	A0A0H3U4C7	Staphylococcus_phage	4.8e-35	100.0
WP_000854072.1\|2077322_2077586_-	helix-turn-helix transcriptional regulator	A0A2I6PF09	Staphylococcus_phage	7.2e-41	100.0
WP_001031454.1\|2077719_2078433_+	helix-turn-helix transcriptional regulator	M9NUL0	Staphylococcus_phage	1.2e-130	100.0
WP_000759682.1\|2078448_2079381_+	ATP-dependent helicase	A0A2I6PEZ7	Staphylococcus_phage	5.7e-173	100.0
WP_000591749.1\|2079386_2079728_+	hypothetical protein	A0A2I6PF04	Staphylococcus_phage	4.6e-56	100.0
WP_000694772.1\|2079931_2080114_+	hypothetical protein	A0A2I6PDF8	Staphylococcus_phage	6.9e-27	100.0
WP_001558608.1\|2080213_2081197_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_000427213.1\|2081207_2081450_+	hypothetical protein	NA	NA	NA	NA
WP_000857180.1\|2081512_2082550_+\|integrase	site-specific integrase	Q38086	Staphylococcus_phage	1.4e-175	98.6
WP_000595392.1\|2083668_2084685_-	bi-component leukocidin LukGH subunit G	A0A1X9IGW5	Staphylococcus_phage	6.7e-26	30.2
2083746:2083763	attR	NA	NA	NA	NA
WP_000791411.1\|2084706_2085762_-	bi-component leukocidin LukGH subunit H	A0A1X9IGW5	Staphylococcus_phage	2.8e-35	34.3
WP_000206625.1\|2086197_2087421_+	ArgE/DapE family deacylase	NA	NA	NA	NA
WP_001045079.1\|2087864_2089172_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000240655.1\|2089711_2091328_-	chaperonin GroEL	A0A240F779	uncultured_virus	2.6e-157	54.7
WP_000917289.1\|2091403_2091688_-	co-chaperone GroES	A0A221S386	uncultured_virus	4.7e-14	46.2
WP_000197635.1\|2091862_2092606_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NC_017340.1|WP_000681968.1|2033775_2033952_-|hypothetical-protein

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Acr_ID: NC_017340.1|WP_000990056.1|2034194_2034293_-|hypothetical-protein

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Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_017340.1|WP_000681968.1|2033775_2033952_-|hypothetical-protein

2033775_2033952_-

58 aa aa

2009150-2092606

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_017340_5	Unclear	5.2\|821297\|23\|NC_017340\|CRT	821297-821319	23	2087723-2087745	2
NC_017340_5	Unclear	5.4\|821414\|23\|NC_017340\|CRT	821414-821436	23	2087723-2087745	2

1. spacer 5.2|821297|23|NC_017340|CRT matches to NC_017340 position: 2087723-2087745, mismatch: 2

tctgtagaaattggaaatccaat	CRISPR spacer
tctgttgaaattgggaatccaat	Protospacer
***** ********.********

2. spacer 5.4|821414|23|NC_017340|CRT matches to NC_017340 position: 2087723-2087745, mismatch: 2

tctgtagaaattggaaatccaat	CRISPR spacer
tctgttgaaattgggaatccaat	Protospacer
***** ********.********

NC_017340.1|WP_000990056.1|2034194_2034293_-|hypothetical-protein

2034194_2034293_-

32 aa aa

2009150-2092606

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_017340_5	Unclear	5.2\|821297\|23\|NC_017340\|CRT	821297-821319	23	2087723-2087745	2
NC_017340_5	Unclear	5.4\|821414\|23\|NC_017340\|CRT	821414-821436	23	2087723-2087745	2

1. spacer 5.2|821297|23|NC_017340|CRT matches to NC_017340 position: 2087723-2087745, mismatch: 2

tctgtagaaattggaaatccaat	CRISPR spacer
tctgttgaaattgggaatccaat	Protospacer
***** ********.********

2. spacer 5.4|821414|23|NC_017340|CRT matches to NC_017340 position: 2087723-2087745, mismatch: 2

tctgtagaaattggaaatccaat	CRISPR spacer
tctgttgaaattgggaatccaat	Protospacer
***** ********.********

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_017340

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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