CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014008	Coraliomargarita akajimensis DSM 45221, complete sequence	9 crisprs	DEDDh,DinG,csa3,Cas9_archaeal,cas3	2	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014008_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014008_1

339795-339934

Orphan

Consensus_repeat	Method
AAAGTGAGAGTGTTCCGAGGCGCTTGCGCCGACAAGGCCGGATTC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NC_014008_1

>merge|NC_014008|1|339795-339934|CRISPRCasFinder
AAAGTGAGAGTGTTCCGAGGCGCTTGCGCCGACAAGGCCGGATTCCGCGAAGTGGAAGACCGGACCCAGTGAGAGTGAGAGTGAAAGTGAAAGTGAAAGTGAAAGTGTTCCGAGGCGCTTGCGCCGACAAGGCCGGATTC

>NC_014008|1|1|339795-339934|CRISPRCasFinder
AAAGTGAGAGTGTTCCGAGGCGCTTGCGCCGACAAGGCCGGATTC	CGCGAAGTGGAAGACCGGACCCAGTGAGAGTGAGAGTGAAAGTGAAAGTG
AAAGTGAAAGTGTTCCGAGGCGCTTGCGCCGACAAGGCCGGATTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014008.1\|WP_169305281.1\|323494_324577_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_052293077.1\|340971_341880_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187576
NC_014008.1\|WP_013042003.1\|316932_317913_+\|methionyl-tRNA-formyltransferase	unknown	unknown	gnl\|CDD\|234567
NC_014008.1\|WP_013042010.1\|335504_337043_-\|arylsulfatase	unknown	unknown	gnl\|CDD\|293761
NC_014008.1\|WP_041745330.1\|338738_339770_-\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|238368
NC_014008.1\|WP_013042014.1\|339991_340909_-\|oxygen-dependent-coproporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|235413
NC_014008.1\|WP_013042008.1\|325690_334378_+\|YD-repeat-containing-protein	unknown	unknown	gnl\|CDD\|225750
NC_014008.1\|WP_013042020.1\|344171_346964_-\|DNA-polymerase-I	unknown	unknown	gnl\|CDD\|235591
NC_014008.1\|WP_013042018.1\|343174_343489_+\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NC_014008.1\|WP_013042017.1\|342579_343083_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238017
NC_014008.1\|WP_013042005.1\|321736_322504_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|225076
NC_014008.1\|WP_013042007.1\|324630_325656_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013042004.1\|317977_321532_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375510
NC_014008.1\|WP_013042019.1\|343498_344095_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NC_014008.1\|WP_013042022.1\|347309_347468_-\|small-basic-protein	unknown	unknown	gnl\|CDD\|275006
NC_014008.1\|WP_013042002.1\|316268_316940_+\|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|176648
NC_014008.1\|WP_013042024.1\|349076_350006_+\|phosphatidylserine-decarboxylase	unknown	unknown	gnl\|CDD\|179097
NC_014008.1\|WP_013042012.1\|337420_338746_-\|protoporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|215314
NC_014008.1\|WP_013042016.1\|341989_342445_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341391
NC_014008.1\|WP_013042023.1\|347723_349073_+\|voltage-gated-chloride-channel-family-protein	unknown	unknown	gnl\|CDD\|239654

Protein	Function_ID	Function_description	E-value
NC_014008.1\|WP_052293077.1\|340971_341880_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187576	cd05266, SDR_a4, atypical (a) SDRs, subgroup 4. Atypical SDRs in this subgroup are poorly defined, one member is identified as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is related to, but is different from, the archetypical SDRs, GXGXXG. This subgroup also lacks most of the characteristic active site residues of the SDRs; however, the upstream Ser is present at the usual place, and some potential catalytic residues are present in place of the usual YXXXK active site motif. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.26119e-53
NC_014008.1\|WP_013042003.1\|316932_317913_+\|methionyl-tRNA-formyltransferase	gnl\|CDD\|234567	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed.	4.50111e-94
NC_014008.1\|WP_013042010.1\|335504_337043_-\|arylsulfatase	gnl\|CDD\|293761	cd16142, ARS_like, uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	0
NC_014008.1\|WP_041745330.1\|338738_339770_-\|uroporphyrinogen-decarboxylase	gnl\|CDD\|238368	cd00717, URO-D, Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction is located at the branching point of the tetrapyrrole biosynthetic pathway, leading to the biosynthesis of heme, chlorophyll or bacteriochlorophyll. URO-D deficiency is responsible for the human genetic diseases familial porphyria cutanea tarda (fPCT) and hepatoerythropoietic porphyria (HEP).	5.08006e-155
NC_014008.1\|WP_013042024.1\|349076_350006_+\|phosphatidylserine-decarboxylase	gnl\|CDD\|179097	PRK00723, PRK00723, phosphatidylserine decarboxylase; Provisional.	9.51346e-127
NC_014008.1\|WP_013042008.1\|325690_334378_+\|YD-repeat-containing-protein	gnl\|CDD\|225750	COG3209, RhsA, Rhs family protein [Cell envelope biogenesis, outer membrane].	4.90541e-13
NC_014008.1\|WP_013042020.1\|344171_346964_-\|DNA-polymerase-I	gnl\|CDD\|235591	PRK05755, PRK05755, DNA polymerase I; Provisional.	0
NC_014008.1\|WP_013042018.1\|343174_343489_+\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	9.27412e-28
NC_014008.1\|WP_013042017.1\|342579_343083_+\|FHA-domain-containing-protein	gnl\|CDD\|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	1.01351e-06
NC_014008.1\|WP_013042005.1\|321736_322504_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	6.68721e-11
NC_014008.1\|WP_013042014.1\|339991_340909_-\|oxygen-dependent-coproporphyrinogen-oxidase	gnl\|CDD\|235413	PRK05330, PRK05330, oxygen-dependent coproporphyrinogen oxidase.	0
NC_014008.1\|WP_013042004.1\|317977_321532_-\|hypothetical-protein	gnl\|CDD\|375510	pfam18040, BPA_C, beta porphyranase A C-terminal. This is the C-terminal domain found in Bacteroides plebeius of proteins such as beta-porphyranase A (BPA), a beta-galactanase that cleaves the beta-1,4 glycosidic bond. Porphyranase degrade red seaweed glycans. This domain adopts a beta sandwich shape.	4.73199e-09
NC_014008.1\|WP_013042019.1\|343498_344095_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	3.01289e-87
NC_014008.1\|WP_013042022.1\|347309_347468_-\|small-basic-protein	gnl\|CDD\|275006	TIGR04137, hypothetical_protein, Chlam_Verruc_Plancto small basic protein. Members of this protein family are commonly found next to markers of rRNA processing such as YbeY. They are extremely lineage-restricted, in the Planctomycetes and Chlamydiae/Verrucomicrobia group. Since classification is based on rRNA molecular phylogeny, this provides additional support for a role in rRNA metabolism. This small protein, about 50 amino acids in length, is rich in basic residues, a third line of support for rRNA interaction.	1.18806e-17
NC_014008.1\|WP_013042002.1\|316268_316940_+\|3'-5'-exonuclease	gnl\|CDD\|176648	cd06127, DEDDh, DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI, ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III, the main replicating enzyme in bacteria, which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T, Oligoribonuclease, and RNA exonuclease (REX), among others.	3.86784e-21
NC_014008.1\|WP_013042012.1\|337420_338746_-\|protoporphyrinogen-oxidase	gnl\|CDD\|215314	PLN02576, PLN02576, protoporphyrinogen oxidase.	1.07224e-112
NC_014008.1\|WP_013042016.1\|341989_342445_+\|CBS-domain-containing-protein	gnl\|CDD\|341391	cd04623, CBS_pair_bac_euk, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria and eukaryotes. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	7.29479e-46
NC_014008.1\|WP_013042023.1\|347723_349073_+\|voltage-gated-chloride-channel-family-protein	gnl\|CDD\|239654	cd03682, ClC_sycA_like, ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation competitiveness, and N2 fixation on Phaseolus vulgaris plants, due to its reduced ability for acid resistance. This family is part of the ClC chloride channel superfamiy. These proteins catalyse the selective flow of Cl- ions across cell membranes and Cl-/H+ exchange transport. These proteins share two characteristics that are apparently inherent to the entire ClC chloride channel superfamily: a unique double-barreled architecture and voltage-dependent gating mechanism. The gating is conferred by the permeating anion itself, acting as the gating charge.	3.68096e-175

>NC_014008.1|WP_041745330.1|338738_339770_-|uroporphyrinogen-decarboxylase
MTSRQRFLAAAACQPVDRPPIWLMRQAGRYLPEYRELKAQHDFVTMVRTPELAAEVTLQPLKRFPLDAAIIFSDILVIPEALGQGYHFRDQGGIGMDYLLDTAEKIEALDAEKVTERLAYVASALELTKFKMDGDKALLGFCGSPWTLACYMVEGGSAKDFIAIKRMAWDQPELFEKLMQKLTHAIIDYLHMQIDAGADALQIFDSWGSICPAIHYEAWSLRWIHDIINALKGRVPVILYAKGMGHKSPDLLRTGASILSLDWTLNMRRMRKVLGPHVTVQGNLDPVTLTTTPEIVRKEAMRLIDDIGRQPGFIFNLGHGMLPSAKIECVEALMEVVTGQKNA
>NC_014008.1|WP_013042012.1|337420_338746_-|protoporphyrinogen-oxidase
MPDTCIIGAGITGLATAWQYQRKGKDCVVLESGPQVGGAIQSILQDGYLAEEGPNSIQLNSLEIEDFLTSIPGLEAQIIEANPAAQKRYIVRKGRLRAVPMNPLQAITTQLWSIAGKLRVLREPFIKAAPPEPDQSVADFVTRRLGKELYDYAINPLVGGIYAGKPEMLSLRYGFPKLYALEQEHGGLIRGALAKMKAAKANKGPKAKKYILSFKDGLQTLPQSIANNLNEPVQTGVSIESIRQIEDMWAVRWNGQVKAFKELIVTVPAHKLPGLPFEEPIRLPAIDYPPVSVISLGYPLSAIKQPLDGFGALVPEREDRNILGVLFPSAVFDGRAPEGHGLLTVFVGGSRSPECSSPDTDQLLKTIQPDLETLLGIQDEPSFVHHKHWPMAIPQYTLGYEKVLEAITRIEQQYIGLKLAGNYRTGISLSYCLESAIASTN
>NC_014008.1|WP_013042010.1|335504_337043_-|arylsulfatase
MKPILVASILGLISITGYASDKPNILILFPDDVGWQNVSAYGHGTMGYRTPNIDRIAKEGALFTDHYAQPSCTAGRAALITGQYPIRSGMTTVGRPGAELGLKPQSHTLAEVLKELGYATGQFGKNHLGDRNEHLPTVHGFDEFFGNLYHLNTQEEFEQVDYPKDPEYFKKFGTRGVLHSWATDEENTTIDPRFGMVGKQTIEDTGQLSRERMKTMDEEFIKASLDFIERAQAAEQPFFVWFNPCRMHMYTRLSDESRYLAAEHTTEHDFYGSGLMEHDKQIGELLDALEEMGVLDNTIVIYSTDNGPEHSARLHGGTTPFRGEKMTTYEGGVRVPLMIRWPDKIAPGTVLSGIQTHMDIYTTLAAAAGEPDIANKVLREQEQFIDGINNLDYWTGQATKSKRDHFFYYYESSIKAVRYKQWKLHFETSENYYAPYEKQKFPVMYNLRMDPFESFDGTTDRSDIIQSKQWLNEPIQHLLSEHIQSLAKYPPVQKAASFDFSALIEQLMQGKQ
>NC_014008.1|WP_013042008.1|325690_334378_+|YD-repeat-containing-protein
MRLSLLALAAIVQPIVFTSGLSAQQQGPNWWYTPSDGGAPVAVTPAASAADNQTVANIGQAKWMAMRAIEEMEAQAPGSALGDSAQNEGDAGYQSLSELYDFLQVSSGANVDNFAPLNLGQLKSISAPFYERFDELSIDPLGPTSLNLVPTGAGYSIYPWTDATEDDLNYALAQLGQLKHVLGFQLGSHWVPTTDGDGDGIPDWWIGSDEVIIHSIKLSSLSESLGVYTVQIAVQDARGSAVAGAAVTIAKDVGTGTLSNTVVTTDSQGTASFTYEPSSVGAHILSAALADAKTLRVYIDAPVSTPHITQSAPGIQQDRDPLSESGKTSGLVGPYSDYYSLTPGQYTIYERHENGEAFPYWESPYDYAYGGVMLYTSTAISEGSPEIDRMHLYLASDFSLAIEHRVVREGLLPQVPVLTASFDTESAIWYFYVDEFSPPGEATKNAATANYSLTYYSQSFTHAIAAPGIQGTIDIPWSNHSFGESYSEGESTAICPGVWIYGFSSDGYLSDQQKYTYSYGTDTFELRSSISVLLDGTALNFELPSGIESLREELYETKSNTEDTRLYSDLYWTFEVLSLSGSSQSLSNLGISVYLVTTLAESETRQPVQLPVGQEVRFLEPEDGVFTRLEFELHETPSCNFVLKVGAELVGVWNNTNLGAQFIRYVVPEASQPASMPVDEAAGPKYRKIALNGRPISDDKPQSEAESDEEPEETYIDALSLSLRHSVTDIYVPVPASDLALSVRRNAAPEIWSLKNGLRPHERLDLPFGVGWSTNLTPTIKLTLGDYTGVSSTPTDPDMATVYDENGEAFSYAIKYKAGVYQNGISPVTSPTTANIDGFIARPNGRHNQQAYLNDLAISDDGTTFTLSKRFGTTVTYELVAGASHVISANRMNGSEVSQKIYYARATKVTDKYENSLIYKYAGSSLIPHLVAYDSDNDSDADDESLRILVGYSNGRIDQVVDPNDNIISYGYANGAISIEAPHLTAGEQALLDNGFNFGTSYPTLSTVTHADSSETNYGYYYTKELDEYSELIDIENNKFHHHHVYLNSITDANDNEYRFVYDQMGSYYDWHQALWLQVLELDGDEHTGYYKPSGRPFKVSGVDLPAVGAEGTVDVSFNDNSVIALGQGAVLSGCLRETVVEDAEGSTITYNWPIEGYTDVEELPDVRNSYGTDEEDFSTPMMVYFKRMQITYAMGAGNEDLTETFDFNPDAGMAVAQASDVNSNLTSFAYNDVLTGGYYASRYPEPTSQQNAHADTKSFTYTDTALSGRVMDSITDEAGRYTHYTLDSIGRRTHERIYKSQGGQLLSHTEFTYDTSLKGFMRQRIVHSHASDALLPADPTWSNGAVPDKMVTLYEPYTSGVDKGRVKRQAVDMDKSGTISDGDLITSYTYDANGNRRSITDPNNYTTWFFYDERNRLKQTIYPDDTSRQTVYDPRGNVVLEINENGKLVGHEYDQLNRRIRTIVDMDGDLVFDSAHEDHFTGDSAPDLITTFAYNDVNSLTVTVDPRGYGTRNQYDNLQRLRKTIAPVADAQLDAQTGIYVPVVDSATDYTTQFEYETSKNSGSGLFSSTAFKPTLITDPRGYETRNEYDELYRLERSKVQYEIGAIEPEHKFATTSYEYDAVGNQTAVVDPLSKRSETVYDGLNRPIATLLAVGTSDESVSLSAYTSTGLAYQTIQLVNGSYHAATQLYTAGTLDRKTDTEYDRAGRAVLQLQPQVYDAVAQTNDRPETRTGYDANGNVVQSINPRGYTWDTYYDSRNRPYITLEPGTYDASINEWGRARVDTFYDAVGNVTSITDARGYSTYTTYDAANRPRLVMSPEVTFANGTTGYPALRNTYDAAGNVLTIEHGTVADPAVAEPVFTSARTSTTNTYDALGRLKTTMDAETIVVHNEYDEVGNRIAVIDGKNQRTEFTYDGLSRNTATLNGVFGAGANEYADATVFVFDAVNQTDRYRGVTPSAAGQHTSYDYDHRHRLKTVDYGADLVIDRAYHYDVLGNILVVDEAGTQSDVAYVYDALNRIRAEHSAGVWHLYEYDLAGNRDASFYAVTDAALTTPELLIASPVSESTLSRSGAVSAHRSIQTTYDSVNRTATMTEGDRQGQYRYDFSGSIIEKWQANGDRVIQAYDALGRVETIRGPGLIGDELYVTQNAYDLYGNLAKITETYPQGKLTDRIVENSYDGANRLHTETITSGAHVVITTYAYDAAHNRTLRQMDADGSGSFSTGDIHTRTVFTNALNQPAYSYTDSNNSGSWESGEARVDYLHDDRGNRQSAAEDTNGDGVSDRTVNYVYDYENRLEQLSNATGTYSYAYDYRTRRVVRDESAAGGSRTVVSFSGGTSVREYANGAVRPNVEYIRGSDYGGGIGGILYTVRPDYIHLESLPLSAYSTGQDGQYGISTNATFAGDGYELQIGSNSWKKFDFSYTVTPNTMLTFEFFSDDDGEALAIGFDNDNSYLTAPPASLLKLSGDQTGLNPSRFNQTYDNYEVGSGWKAYAIPLGDHMSGPMTELVFVCDEDRTSHTASARYRNIQIFEGTAQELVSFKHYNARGDVVAATDASGALTYQAAYEAFGQHGSTDSSADWGSTLDRQQANTKDEDPTGLLNEGFRYRDLESGTFITRDPLGFVDGPNVYTYVVQNPWTFFDPLGLNKFDSAKMAALRAKAQDPNNSAMTRLGAAFQALGTGLNPFNSESNLRVGMRQFNQNAEVARGKLKEAPPVIREVSQFTMGVGMAGTAPLSVPAGVGELTDAVQQKGITQTAKDVATGLVDHALSNPVEFAGEMVVAGAATKPLKATPKQTGTTTVTSWADEGITPVLNSGKWVMKGEATLWNFWKSGLPGPKATWTSKFPFIKFEKSKADFSNSITDKVPNSSLKTPPGAEAWKASLGQRVLKETAEEAE
>NC_014008.1|WP_013042007.1|324630_325656_+|hypothetical-protein
MKRITKTVGSLLFLNMCSSMSAETLIIEGDLAVDNTPSVTTDEPIVQTYPGAFTILGGHVAQGGTEQRSGAMLRIGSMTQGATKSDTEGTYFEWFSSVDFNDYGQHVVYLYIGEFPFQMWGYFDVTVASDYWGPGKVGRGAITKRFPVAFNTYQATYPGALHAPAGESSAVIAAAGGIIDYVTIGEIEQVEDKLRVPIYFLAGSHSLAGIGMSGMFTRAYNEAGYPYAAVESNLDTVTLNNAVEIQDLQVANSVQVDGDIVIAGTIESTAGGFVLPDGTVLDEAADLNSGGGSSAEANKLTTPDLTTDVVIVDNSKHITVDGTMTFTAPMGDISMGVFGAQ
>NC_014008.1|WP_169305281.1|323494_324577_+|hypothetical-protein
MLKFKQVGGIARGYTAPVFMQMLLALHLQAVTLPYANDFESADGYTTTGYLVSDVDWAFDPNLLTVEVTDTQAAHGTQSLLLTGTSNFTLGVVDGLVESYRWIDFYLKPVFVLETELPQQVTSLQPAVTAFVTDGSAGEVFVVDGDGLGGGSWVSSQMPIALQGGTPLDWVRITYRLDYSRKTWDLYVNGQLSLVNMGFLDDSLTELNAFSFTADPVQSTALDTFFAGIVNPLYSDADQDGIADSVDLNSFLDDRDVDSDGDGLTNIEEYQHGRLLAFPDADVACYVDAVLGDDAVYNGYSAVPGMPTVSSGPKSTLTAAMNEAAHGNIILMQSGTYDETVLSLNGKDLTLRISGSVTIR
>NC_014008.1|WP_013042005.1|321736_322504_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MFTSPQKKTSLSARRRAFTLIELLVVIAIIGILAAILFPTMGAVRQNSKAATSISNLRQIGIGMDLILNEGAPGLPKGYYPCYGGTDFGPWVQYGVLELVAEKFEMAYRKNGKFFWPQDPATTIFQNPFDETDYNPASAGSTAGYGYNTLQLCTSSWKHASHNLGIYKSANEPTTQVNFSKQQIFNVSNMIIFAENDADLSKTNRYTSSQYGWSGQPSDDYKGGGHYLFADGHVAWMSREDLMAQPTKFYNRSGK
>NC_014008.1|WP_013042004.1|317977_321532_-|hypothetical-protein
MRKHLPRNTRLALVGCLLSCLLWTSCEKPQPEPSAPAPKPATTDTKPAPNAVDSQVPAYSADCLLELDATAITQQAGERLSQASLIQEPSIQNYLGGDYRQLFPILKALQDKRAAQSTYAAPLPSDDLSFGQQQALIDLLQNAANEQLGTSIKLAYALPAHYSLSESVELQMRADLALPLAPPTAYAQVMQSLFAGAGEQRIQLSSSAADIQGLAYKTDTGLLVCLLNSGSEPMSLAIPALAGKTASAQSIDLATEQQLSSTRIDNPAEFELQAGQFLRLDVQHTPAPANKREKRYIYYGDAIATQLKQQRHCTIPIGMPQAATSSELRVGAIGTSAELEQVRIAFNGRILPADQLIIESHTDGISSIRVPIPVEQLQPNNQVAFALPESQSFLLTAAVLDNRMNLDTRTTDSSALAVAASPVQELAPGELPPAGQFEKERLESLWEVVAERYECKIDTQVNDRSNSRIFEVRFDVTVKDGKVDLPPDVVRVWPLFESLALEGDNLRSGSYKLVSPIGTGHYHVHGNDTWVTGHATRLDVIDGDDYSDHYLTVPSGAKVERMILSSKLGVSQRFDASIWSTLGSDKPIEPVTVQLDATALRGIGGETNLLRERFWRFAGSIHASSRNASVIQLPIDNGFVPGRGIFKLDGLLTWGFQGRKLQEDPNNPGKPDYSIFENVTYEASEVEARKQLYGEPTWCNCFDNWPYFMAHQGTKVPNDRGTPINYEDAAELSSRYIQAEKDRLGKTANWWEVKNEGTVSSEWVLHSEPGYDGWAELAKFHIAMAERIRADHPEVKVGGPASAWMALDHADFRVGQEQLDFMDDTKGKLDFYSHHFYENTDLVLNGGEAHSGGYLTGRLEGVIDLLWNHGYLTDNIKPWLITEYGTLGGGGSDPIQWVEIKNYNSYLVRYMNQQDKIHLTNAFILPLVHWEKGTDQGLYIYNEDGEIVLNNKLYYYFEFWKDYKGKLLPVRVSEPDHTAVHTHAVLSGDTIRIAVNNMNAHRIHVNLQAALGSLRAKSITQHRLYLQNAAIVRESIELDSLTQIPLSVEETSIIEIKLNGVPRIAQYRDERTLYGDSILEPTGGSAKFKVEVPQGKILRARLRVAAARVNGFEGAMTVMVNGTKLEEKIELTPEAKSGRYWGWANFDVPANLLKPETSISVRINQEGGYITSVALIPEYAEFLR
>NC_014008.1|WP_013042003.1|316932_317913_+|methionyl-tRNA-formyltransferase
MSDLPAVVFFGSDAICLPFLNYLLLEGREQCTVRAVVSQPDRRQGRGKKLQPNPVSAWAREHGIELLQPDKPGKDLAEWLQDEQIALCFVMAYGHFLPKSVREAAEHGMVNFHGSILPDYRGASPVETALALGEETTGVSLMEVVREMDAGGVADVEVVPIDLTDTGPSLRVKIGEAVVPLMRRNLRQAVTGGLHFVAQDASRASFCRKIFKDDAAFDFNQTATALCARLRAMTPWPGGYFEYASERVKVGACSILPGPSQAPVGTILAAEDAVQVACAEGVIQFDQLQRPGGRMLPAAEFLRGFPIEVGTQLESTASAPLLSRVE
>NC_014008.1|WP_013042002.1|316268_316940_+|3'-5'-exonuclease
MFTTPIHVIDFEGSRQSGIVEYGVVTLHGAMVEATYTGLCLPRGTISDRDRMQHRIAESDLQEEQPFEVQWPLFSMLRETGVLCAHNVQVEEGFLRSVWPYPKASPDFLEIDGAPQLSWGPWLDTLYLYRRIYPNLESHRLEDLVQLFGLSAELKGRAKLYCPPGRRRYHSALYDALASALLLSRLYDEPELKRMTLHWLLIHSQPSEAAREAVGQQEFYLNE
>NC_014008.1|WP_013042014.1|339991_340909_-|oxygen-dependent-coproporphyrinogen-oxidase
MPSTQSELVRNYLLSLQDSICKALEAEDGSATFHEDSWERPEGGGGRSRVLADGAIFEKAGINFSDVHGKGLPPSATAARPQLAGAAFRAMGVSLVIHPQNPHVPTTHMNVRYFEASPTEGEPVWWFGGGFDLTPYYGQKADAIHWHQTAKAACDPFGTELYPRFKQTCDDYFYLPHRNEARGIGGIFFDDFNAGGFDQAFAFMQSVGDHFVPAYQPIVARRKEQPFTDAERQFQLYRRGRYVEFNLVYDRGTIFGLQSKGRTESILMSLPPLVRWDYDFHPQPGTPEAELYETYLKPQDWVSMH
>NC_014008.1|WP_052293077.1|340971_341880_+|NAD-dependent-epimerase/dehydratase-family-protein
MNDAPKQIECLPESVMIFGCGYVGRALAQRLLQAGVRVGALTRNADKAAELKALGLQEVVVADLDSDAWHDALSGTYGAVVNCVSSAGGGLAGYRRSYVEGQASILRWAQTQELSAYVYTSSTSVYPQSEGVIVDEAADLSAASESGRLLLEAENLLAAGAPQGVHWTVLRLAGIYGPQRHYILNQLRDGLQVFPGSGAHRLNLVHRDDIVEGILLGLMRRGAAGIYNLADGTPVTKQALVEWIAEQLHCPVPSFDPSQTPPRQLRRGAQVPDRVIDSQKAQGLLGWTPKFPSYREGYRDLL
>NC_014008.1|WP_013042016.1|341989_342445_+|CBS-domain-containing-protein
MPLNKVSVVSILKEKSSSVHCVAEQVTVAEAVNEMNRQRIGSILVKADDGTVTGIFTERDVLVRVVSAGRDPQATKVQEVMTPDFESIAPDTSVEDAMQLMTEQRVRHLPILDGGTLCGMISIGDVTRWLLQVNEMEAENLRKYVFAEYPG
>NC_014008.1|WP_013042017.1|342579_343083_+|FHA-domain-containing-protein
MAIFRNLLRKQSWQADDHAGSAVLSADEIHDAIESAESLDSELAEVWLEPDSEYTQAQSLLSKRQLVDRIFRIGRRGAFANTGAVDQLDYALAQNEPYTISKLHCELELRPTGVLVRDLGSRYGTKVNDLRLGERFSGKQSIALTKGRHCLVLGPRGSRFRFVIEVK
>NC_014008.1|WP_013042018.1|343174_343489_+|YbaB/EbfC-family-nucleoid-associated-protein
MAGVGKLLKQAQKMQKQMQAIQEELAEKELEISSGGGAVSITITGQSEFRSIKIDPEFLKEDAEFVEETLLGAIQEATAKAKEVNEEAMGALTGGMGGGFPGLM
>NC_014008.1|WP_013042019.1|343498_344095_+|recombination-protein-RecR
MTPAFEELLQQFKKLPGLGYRSAERIAMQLLVEKPESLERLLSSLQRAQQVVGRCEQCGNLAEEGTCAVCTDERRDPQVLCVVEHVTDLMAIERSAAWKGQYHVLHGKLSPIHGVGPEDLNFSALEKRLSAGSIREIVLALSNDIEGQATCHYIQEEIVGERAIQVSRIGFGLPSGGGVTYADSVTLKSALEARRVYE
>NC_014008.1|WP_013042020.1|344171_346964_-|DNA-polymerase-I
MKSLFLLDGMALAYRAHFALIRSPIYTSKGFNTSAIFGFTGTLIELIKSGNPSHLAIVFDTSAPTERHRIHPEYKANREEMPEDLRSAMPHLDRIAEAFDIPVLKLDGYEADDIIGTLAHRAEAEGFDEIYMVTPDKDFGQLVTERIKMYRPGRKGDGAEILGVDEVKAKWGIARVDQVIDMLGLCGDSVDNIPGVPGIGPKTAEKLLAKYDTVEGLLDHVDELKGKQQEKVRDNADQARMSKLLATIQKDVPIAVEWSALELHAPEQSKIVPLFTEFEFRTLGKRIFGNDFSVQEAATDLVLMSEDDEQAAAASSETPAGGQLDLIPAITFKKLADVTHTYAIADTTEQLQRLCTELREAGSFAFDSETTALNPRQAELVGLSFATKAHSGWWVPASSEALDALRPLFADNSITKIGHNLKFDLAILAAQSCPVDGPCYDTMLAHALIEPEQRHNLDTLAEDYLRYSTIRFSELMPDAKKGSPLDYSSVDPQALADYATEDADVTLQLWECFKPKLEESGQASIFYEIETPLLPVLVAMESEGIRLCTETLEETGRVLEGQIATLKDAVYAAAGREFNLNSPKQLGEVLFNELKLVDKPKKTKTGQFATNEQVLSSLAPKHPIVADLLEYRQLSKLKSTYIDALPNAVDPVSGRVHTHYGQVQTATGRLSSNDPNLQNIPVRSAQGREIRKAFVPREGWTLLAADYSQIELRILAALTADEGLLTAFREGRDIHTATAAKIFEVDADTVSRDQRSTAKMVNFGIPYGISAFGLAQRLGTVSRTEAQNIIDNYFAQFPGIPGYMQAQQESARAKGYVATVCGRRRYLRDINSGNGTIRAAAERNAINMPIQGTAADMIKLAMIRVHHAIIDAGLKSRMLLQVHDELIFDLAPGEESALRQLVTGGMQDALQLACPIEIEIGTGMNWLEAH
>NC_014008.1|WP_013042022.1|347309_347468_-|small-basic-protein
MSQHNSFKASGGGGKKNRTVLKRFERVELLRKRGEWKEGDRVIGLKKTQPEA
>NC_014008.1|WP_013042023.1|347723_349073_+|voltage-gated-chloride-channel-family-protein
METSQYSFEQLRIARLLLRWIVLVLPVAVAVGVMVAFFLWLLGLATNLRHAQMWLIYLLPLGGVGIVWLYRRFGKNSEAGNNLIMDEIHTPGGGIPFRMAPLVLLTTVLTHLFGGSAGREGTAVQMGGSTAEYFAQKLGLGKEDKRILLMAGMAAGFGAVFGTPVTGAIFALEVLAVGRIKYDALLPCLFASLIADITCNSLAVHHTHYAIGYSAREAMEHFGGIDFDLILLLKVLLASACFGLASFFFAELSHGLKALSQAFLKPWWLPPVLAAVLVLGISYCLGTWDYLGLGVYSSQEGGVSIVNAFEAGGATSFSWFWKLLLTAITLSFGFKGGEVTPLFFIGATLGNALAVWMGAPIDLLAGLGFIAVFAGATNTPLACTLMGVELFGAENLIYYAIACFTAYYFSGHSGIYGSQRVAVSKFHTTLSGEQTLKQLKAQRNASKKD
>NC_014008.1|WP_013042024.1|349076_350006_+|phosphatidylserine-decarboxylase
MANQDVLNAPIQFVDRASGERLTEEVYGEAFLRWAYGNPLGRLTVAVAVKRLWFSRWYGWRMDRAKSRSKVAAFIQDYALDADEFADPIESYQTFNQFFYRKLKPSARPIDATASRAVFPADGRHLVIPEVDSASTFYLKGQRFDLARFIGDSTLAEAFQGGALLISRLCPVDYHRFHFPVAGEASAAELLPGSLRSVSPLALRRSLSILWENRRERSLVESPDFGQVLVFEIGATCVGGIHQTYRPGPIKRGAEKGYFSFGGSCVATLFQKDAIRFDADLIEASAEGIEVYAKMGEACGSASSGISDT

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Crispr_ID: NC_014008_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014008_2

389686-389799

Orphan

Consensus_repeat	Method
GACTCTGTTACGACGGTGAGCAGGTTGTGAGGCTTGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014008_2

>merge|NC_014008|2|389686-389799|CRISPRCasFinder
GACTCTGTTACGACGGTGAGCAGGTTGTGAGGCTTGCATGACGTTGGTTGTAACCACGGATTACACGGAGTGCACGGACTCTGGTACGACGGTGAGCAGGTTGTGAGGCTTGCA

>NC_014008|2|2|389686-389799|CRISPRCasFinder
GACTCTGTTACGACGGTGAGCAGGTTGTGAGGCTTGCA	TGACGTTGGTTGTAACCACGGATTACACGGAGTGCACG
GACTCTGGTACGACGGTGAGCAGGTTGTGAGGCTTGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014008.1\|WP_013042079.1\|385674_387021_+\|integron-integrase	unknown	unknown	gnl\|CDD\|131303
NC_014008.1\|WP_013042092.1\|398274_399198_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
NC_014008.1\|WP_013042073.1\|381689_382127_-\|DUF3592-domain-containing-protein	unknown	unknown	gnl\|CDD\|378822
NC_014008.1\|WP_013042093.1\|399226_400087_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
NC_014008.1\|WP_013042095.1\|402088_403822_+\|bifunctional-protein-serine/threonine-kinase/phosphatase	unknown	unknown	gnl\|CDD\|270916
NC_014008.1\|WP_052293078.1\|390063_391263_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NC_014008.1\|WP_013042094.1\|400469_401951_+\|NarK-family-nitrate/nitrite-MFS-transporter	unknown	unknown	gnl\|CDD\|273322
NC_014008.1\|WP_013042087.1\|391419_392427_+\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|234672
NC_014008.1\|WP_013042089.1\|394044_395106_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|372585
NC_014008.1\|WP_013042088.1\|392990_393962_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_014008.1\|WP_148216291.1\|383117_383558_-\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013042077.1\|384209_384449_-\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013042091.1\|396626_398255_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223673
NC_014008.1\|WP_013042076.1\|383502_384105_-\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013042074.1\|382192_382702_-\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013042083.1\|387688_388279_-\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|237728
NC_014008.1\|WP_013042090.1\|395140_396499_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|372585
NC_014008.1\|WP_013042082.1\|387447_387687_-\|molybdopterin-converting-factor-subunit-1	unknown	unknown	gnl\|CDD\|340452
NC_014008.1\|WP_013042085.1\|388901_389588_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_148216292.1\|388275_388755_-\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483

Protein	Function_ID	Function_description	E-value
NC_014008.1\|WP_013042079.1\|385674_387021_+\|integron-integrase	gnl\|CDD\|131303	TIGR02249, Integrase/recombinase_E2_protein., integron integrase. Members of this family are integrases associated with integrons (and super-integrons), which are systems for incorporating and expressing cassettes of laterally transferred DNA. Incorporation occurs at an attI site. A super-integron, as in Vibrio sp., may include over 100 cassettes. This family belongs to the phage integrase family (pfam00589) that also includes recombinases XerC (TIGR02224) and XerD (TIGR02225), which are bacterial housekeeping proteins. Within this family of integron integrases, some are designated by class, e.g. IntI4, a class 4 integron integrase from Vibrio cholerae N16961. [DNA metabolism, DNA replication, recombination, and repair, Mobile and extrachromosomal element functions, Other].	2.77839e-117
NC_014008.1\|WP_013042092.1\|398274_399198_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	2.9585e-109
NC_014008.1\|WP_013042073.1\|381689_382127_-\|DUF3592-domain-containing-protein	gnl\|CDD\|378822	pfam12158, DUF3592, Protein of unknown function (DUF3592). This family of proteins is functionally uncharacterized.This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 150 and 242 amino acids in length.	3.16981e-10
NC_014008.1\|WP_013042093.1\|399226_400087_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	7.1116e-109
NC_014008.1\|WP_013042095.1\|402088_403822_+\|bifunctional-protein-serine/threonine-kinase/phosphatase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.20835e-52
NC_014008.1\|WP_052293078.1\|390063_391263_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	1.35184e-120
NC_014008.1\|WP_013042094.1\|400469_401951_+\|NarK-family-nitrate/nitrite-MFS-transporter	gnl\|CDD\|273322	TIGR00886, Nitrate/nitrite_transporter_NarK, nitrite extrusion protein (nitrite facilitator). [Transport and binding proteins, Anions].	3.27548e-38
NC_014008.1\|WP_013042087.1\|391419_392427_+\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|234672	PRK00164, moaA, GTP 3',8-cyclase MoaA.	2.18284e-144
NC_014008.1\|WP_013042089.1\|394044_395106_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|372585	pfam13379, NMT1_2, NMT1-like family. This family is closely related to the pfam09084 family.	3.27723e-78
NC_014008.1\|WP_013042091.1\|396626_398255_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	5.80312e-45
NC_014008.1\|WP_013042088.1\|392990_393962_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.86419e-62
NC_014008.1\|WP_013042083.1\|387688_388279_-\|NTP-transferase-domain-containing-protein	gnl\|CDD\|237728	PRK14490, PRK14490, putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional.	1.80755e-44
NC_014008.1\|WP_013042090.1\|395140_396499_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|372585	pfam13379, NMT1_2, NMT1-like family. This family is closely related to the pfam09084 family.	2.58001e-109
NC_014008.1\|WP_013042082.1\|387447_387687_-\|molybdopterin-converting-factor-subunit-1	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	2.10012e-20
NC_014008.1\|WP_148216292.1\|388275_388755_-\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	1.55518e-77

>NC_014008.1|WP_013042085.1|388901_389588_+|hypothetical-protein
MSTEGVRYIFDIDGEELVFEVNSEQAAASESDDYPDWVALEHKQCACCPLKTSDCRYCPVAIRIHEVVQTFGARKSTERADVTVETPGRTYSADVDLQVGVNSLLGLLMATSGCPVLKRLGAMANFHIPFCSTQETLHRTVGSYLTQQYFIQLKGGEPDWELTNLKALYGELEGLNQDISKRIHGALESDAMANAVIMFFATSVVVASSLDDQLKRHEAFLTKSGESG
>NC_014008.1|WP_148216292.1|388275_388755_-|cyclic-pyranopterin-monophosphate-synthase-MoaC
MPMEFTHIDKDQKPTMVDVSEKAVTERIAIAESIIYLGEAILAQLEDNNWSSKKGPILDTAIIAGTMGAKKTSELIPFCHPLNLKSVKLNIQPVDKARLRIEARVKVLDQTGVEMEALTAASTAALTLYDMCKAVSKEIVIESTRLIQKTGGKSDFNAQ
>NC_014008.1|WP_013042083.1|387688_388279_-|NTP-transferase-domain-containing-protein
MSTPLFGLLLVGGESRRMGRDKALLSYDDGRSTQLERSAALLQACTDRVFVSQRKEQDFPLPEAVSPIYDQINDMRGPLCGILSAQQQFPHAHWLVLACDLPFLTVDTLQHLIDAFRAEAPQLTAYQSSHDGLPEPLCAIYPSGSDAPLKALADDIGKYCPRKLLILKQARLIKQHDPRSLDNINTDEEYQSLTQH
>NC_014008.1|WP_013042082.1|387447_387687_-|molybdopterin-converting-factor-subunit-1
MQITILYFAQLAELAGKTEEQRHVDSSSVEQLYHSLKEDYTFPHSFDAIQVAINHELTPEGRPLQDGDTLTFLPPMTGG
>NC_014008.1|WP_013042079.1|385674_387021_+|integron-integrase
MKKVHFPRWAEVLEQSDHGVEVKESYRVTVRWYLSWCARHGVACSVESARDFMSWAEREKHPKDWVLARWKDAIRWFFVTGRQQGSGLSVGSLEVEQVGHRVSEVAVCDEATESENGLEREQPMEGKTEDELQILATMRRLGMSLRTERSYLGHYRNFVRQQSVQDGCSMTASAVKCYLDHMAMDRGVASSTQKQALNALVFVAKQVFMVDLGEIGEYVRAKAGKRIPVVLSQAELRALFEQMESEKLLMAEVQYASGLRVSELVRLRIQDLDFSRGQIVIRSGKGNKDRIVPLSEKAAPGLRTHLELVETFFREDQERTDLAGVYLPEALARRHSNAGRDWRWQWVWPSRKVSVDPRSGKLRRHHVLDRAYQRTIREAALAAGITKRVTSHALRHSFATHMLENGTDIRTVQDLLGHRRIETTQTYLHVMQKLGAGVESPLDILYAS
>NC_014008.1|WP_013042077.1|384209_384449_-|hypothetical-protein
MKAHLQKFIFTTLIFGILWPIQDYLNLFSSDRYKRNNAQENLMDPNASGFLDQLLIGLAIGAAISAVMIIASEVKKRKT
>NC_014008.1|WP_013042076.1|383502_384105_-|hypothetical-protein
MRIQEDTAQAIGVALNEATLLGMEWSPEKSLVWSTFSVLTLPEVGPEPEDRRVVLSFENVGRIAMSYRKGFWNDYEAEVIRIKENEILEVIQSFGGQPIYGWEFINTEENELAKWEEKLSLEILNPTGSTTNRISLFQEGATESKHLDIWIWFESFRILNPQTEEISVSDFTEGGKRWWDALHAGDPRTDNHGIIPGKPE
>NC_014008.1|WP_148216291.1|383117_383558_-|hypothetical-protein
MLEILEPTTTVSYPGSLNDANKSRVATPLARHLSTFGEGNRVNPLSKMFKRKPKETWYPNPFEEGKTYKVTQTIFGDFDKLEKGTELTYERTGFSAYDGYIGFFFKDSEGKDRRWDIDINWDPIERAKDKFTALTPKTEQADRGNG
>NC_014008.1|WP_013042074.1|382192_382702_-|hypothetical-protein
MKLKEVFKLASNGKIPNEFLYLPADEKWSLDTVGTFIEWTDEDLDSGDDLPLEAKKENLQEALDGQTIQSIVEWADRLSGKKNDDARLEVFFYYYDYDAFPEKLGGPPPPPADEILTQLDQEFYDQLGEERVDKPCKTEGCSRGSVQYSVFCRIHHFESIKKKPCPFTN
>NC_014008.1|WP_013042073.1|381689_382127_-|DUF3592-domain-containing-protein
MNDNIGIYLFLIVGLSILFMSMFWFFRNVKEKNECIRVNGLIIGHKKEKLGTIGSFTINSSFSPKVRYSYEEKERTHSDQVFTCWKRFSKGDTVGVLVNPHTKEVCIDSFLSRNMGVCVTLFIGLLFTWSAIAFMLGWQNPITPN
>NC_014008.1|WP_052293078.1|390063_391263_-|molybdopterin-molybdotransferase-MoeA
MNALITPQEADARIRAALPTVPSIDCPLDKCAARILREAIVADRPFPPFNRSMMDGYALRSADLQHGTEFHIQHLVPAGSPHQLLGAQAKSCVEIMTGAVVPEDCDCVIPYEQTRTVTEQSMQVLDASRHQTGDCIHRLGSDHFSGSTLLQSGCQLGSREIAIAATCGKQSLQVSRLPAITIISTGDELVPIDQTPQPHQIRRSNDLAIETALACAHFPAKQRRHLPDDRAACTTQLSSAIAESDILIITGGISMGKKDYIPQVLNELGLQNHFHGITQKPGKPMGFWSNQDTAVFALPGNPLSTLVSLHRYVIPALLHASGAQASAPAQLILTAPQKTRDDITTYLPVIVGPDGPAAAPAQNSGDFVSILQTQGFIELPPAQERSHPTGTSVHYYPWL
>NC_014008.1|WP_013042087.1|391419_392427_+|GTP-3',8-cyclase-MoaA
MVQDTRGRGITDLRISLTDRCNLRCTYCMPKEVFGPDYVFLKKQEWLRFSELDAVVAAFVRLGVRKLRLTGGEPLLRPGLLKYIEGLRRFEPIEDVALTTNGMRLAEKVGDLKAAGLKRVTVSLDALDADLCGRMNGRGIGPKVVLAGIDAALKAGLGVKVNMVVERGVNDAEVLPMVRYFKSIGVTLRFIEFMDVGNCNGWNLDRVVSAETLLERIGAEFDFEPLDVSSSREVAKRYRFSDGSAEFGLVTSVTQPFCGGCTRARISADGKLYTCLFASEGLDLKRFLRSPQYTDEALYELLAGRWARRDDRYSELRGQGRVDAEEKVEMSYIGG
>NC_014008.1|WP_013042088.1|392990_393962_-|LysR-family-transcriptional-regulator
MIETIDSRQLLAFCTLVQTGSFTETARELNLTQSAISHSVKNLEEDLRCQLVTRTGRKIHITEDGEELYQHAQAILHQMESARTRIQDRANWGRGRLRVGASTTACQYILPIVLREFNECFPDCILSITPADTPELLDKIRHHEIDLAIIVDPGSSKDVTVRKLFTDELVLVTSSNHPFAQKGSTKMTEIAQERLVLYNKTSQTFGAIEQHFRQNKLALQNYIELGSMEAIKELIKINYGVSYLASWSVENEVNMGSLARITTGPRKITREWGICYANEKKLSITEETFLGICESVASALQPQMSPAPAKKPAKKKAKAKTKR
>NC_014008.1|WP_013042089.1|394044_395106_+|ABC-transporter-substrate-binding-protein
MQNLPPEYSIRTRRSSSVRLGYVRLLDAAPLIVADSLGMFRDTGLDVELSREVGWATIRDKLAFGELDVVQALSPLPFVMRLGLGVAPTEVIAGMVLNTNGNAITLSNQLREEGVDDGESLRRYIKRGYRPRKLALGVVSLYSSHHFILCRWLEQYGIDPKEDVIITVLPPEQMVRNIAAQNIDGFCVGEPWNSLAVEEGLGWCAATSVEVANGYPEKVLATTERFYAYRPDEYTRMIEVLQAACAFCGDKENQTELLRILSKSEYLNCPPKTLANALSGQFPMGFGRVAEGPFIRFCCEKLNQPDAERAGHVFDDLCRYLGSERTSGASRDILTKAYRSDIFESVLASAGSR
>NC_014008.1|WP_013042090.1|395140_396499_+|ABC-transporter-substrate-binding-protein
MRKLLTKLTTTAVSVAGLTTALNAELLDLEKDELKFGFIKLTDCAPIVIAKEKGYFEEEGLQVEVIAQPNWKQLLDNVINGELDGAHMLSGQPIAATIGFGTKAHIITAYTLDLNGNGITVSNDIWKQMQENDPELDTDTPKHPISADSLKPIVEAAKDEGKLLPMGMVFPVSTHNYEIRYWLAAAGIHPGMYTSTDIKGFTGGDIELSTTPPPQMPATLESGKNVAYCVGEPWNQQAVAKGIGVPVTTNYDIWKNNPEKVFGVTKKWADENPNTHIAVVKALIRAGKWLDETDADGNLINREEACRILSQKNYVGADYDVLKNSMTGFFYFQKSDKREMPDFNVFFKYHSTYPWYSDGIWFLTQMRRWGQITEPKSADWYHETAKEVYKPEVYLTAAQHLLEEGHIEEADVPWETDGYKAPTSDFIDGITYDGKDPIGYLNSHTIGNKDEL
>NC_014008.1|WP_013042091.1|396626_398255_+|ABC-transporter-permease-subunit
MAEKTSDAIKYKILRFLDVTGFTVFDPVVRLCFGEEPKKQGEAIFKFMVIPSIFICFCLWLWWTVAPNHKTKSGEVPTPDVVYNSAVINDTFHKRENTKAADFLLEGELRESTLAEVEAQIESNGAVLEELESKLAEQEAAYEAQLNSRISPLQAQLDALKAENKEALATAKAAITAESEKIEAGNGSADTLIAAIRAEGEVKDAGRAKESVIKDQIEVIRSEKYEPLEKARLEVNAVADEQQFLKKRVDILTSSNRSVKVEVAREKLSGSKEGLMAATSAKKAVAEGKKVVRGEDSIERLEGQQYAKAMTVYLQIKRSLFTVFIGFITAAIIAIPVGILCGLSRIAMACLTPIISIFKPVSPVVWLLIFQIVVGAFFPDPESHPFFLFFNSLPIIGGLGINPALIFSACTVAMCAVWPALVNTALGVASIDKDHINVARVLRLNFWERLTKIIIPSAMPLVFAGLRISLGVGWMVLIAAEALSSSDGLGKFVWDEYQNGSSFSFANILYACFVVGAIGFMLDRMMIILQRLVSFDGGNTSL
>NC_014008.1|WP_013042092.1|398274_399198_+|ABC-transporter-ATP-binding-protein
MSYLEINNVSVGFGPVGNRYEVLTDLNLSVEENEFVAVVGFSGAGKSTLISLLAGLLQPDTGEVRIGGKVITEPSPRLGIMFQNYSLLPWLTVFENVALAVKQVFPKYSKAELREHVEKYVAMVKLSPALDKKPSELSGGMRQRASLARTLSMQPEVLLLDEPLSALDALTRAEIQDEIINIWESDRRTIVMITNDVDEAVLMADRIVPLTMGPSAKLDTPFPVNLARPRNRTTLNTNPEFRRLRNDIAKYMVTLNEESKALKSNQAVVDLPEIMPIDFTALPHRPAKGRRRQQLAKALSPETTFFK
>NC_014008.1|WP_013042093.1|399226_400087_+|ABC-transporter-ATP-binding-protein
MRDDRYVDIYNLVKAYPNPFGDEIKVVDGFELKVPRGDVVSIIGHSGCGKSTVLNMIAGLIPISDGGIIVAGKEIDGPGPDRAVVFQAPCLLPWMTSFQNVMLGVKRSYPHASKKERAAMVESALCMVGLADSMHKYPREMSGGMQQRVGIARAIALKPRMLLLDEPLGRLDSLTRMELQDVILRILDKEKITTMIITHDPDEAVYMSDRICMMTNGPHAKVGEVMEIDFERPRNREEIVETDLFYDYRRRLLKFLDDCEAEKEERRQLKKAKASSEGEEPVKKAS
>NC_014008.1|WP_013042094.1|400469_401951_+|NarK-family-nitrate/nitrite-MFS-transporter
MSESKLNILNFKDPSIRTLHFSWVAFFITFVVWFNHAPMVSAITEAFDLTKVQWKALLILNVALTIPARIVIGILVDRFGPRATYSILLMASGVLCTLFALAPTYELLALARFLMGFVGAGFVIGIRMVGEWFPARQVGLAEGIYGGWGNFGSAAAAMLLPSVALLFGGENAWRYALLVTAAVAFIYGIIYYRAVRNTPKGSTYFKPKKTGGLEVTSRKDFYFLIGMNIPMFIALAVLTWRLSSGGVGLISDTFAYVVYAGLVALFAFQVSQIYRVNKDMLKDPEAIPEMHRYKFSQVAILNVNYFVTFGSELAVVSMLPFFFIETFGLDPVKAGFLASGFAFMNLVARPTGGLLSDKFGRRMTMIILILGLALGYFVLSQVSAAWILPLAVVATMCCSFFVQAGEGAVFAMVPLIQRRMTGQIAGMTGAYGNVGAVCFLTVYSFVDASTFFTVIACSSAAAFGASLFLREPKGHTAEVLPDGSVQLIEVGVK
>NC_014008.1|WP_013042095.1|402088_403822_+|bifunctional-protein-serine/threonine-kinase/phosphatase
MLPQDLSVRFGQASEAGVKPENEDCLGVQVPKGDLLSTKGVAIALADGVSAAEMGGEAAEVCVRSFLNDYYSTPETWEVKTAASRILTAINRWLFSRGKDFSEASKGFVCAFTAGIIKSHSLHIFHIGDARVYRLREGELKQLTDDHRVSVSKDVSYLARAMGLSTNLDVDYVRVRLEEGDRLLLCTDGVHEHLSANEIAQRAGDASEDLDAACRGMIQAALANGSRDNVSCQLVVIDSLPDVKGAEIYEELGRLPFPPPLSPGMVLDGYEVESILDESARSQLYLVKDVETGEQAVMKTPAQRRSDDAAYIERFLMEEWVGRRISNPHLVKVLEKRQQAQFLFYLMERVEGVTLAEWMEANPQPEMGVVIDFVSQIISGVRAMHRKETLHQDLKPENIMVDESGRLTIIDYGSAFVAGINEAEVPFERQVDLGTRCFSAPEYVLGRQPSRRSDLFSIGVIAYQLLTGGKGHPYGERLQKAQGIRDFALLEYVSATVYNPLVPKWIDGAVAKAVNVHPDNRYDALSELLADLKTPNPDFMGAEGLPLIQRSPVAFWKGVSGVLSLVVLILFFVLLKG

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Crispr_ID: NC_014008_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014008_3

423675-423765

Orphan

Consensus_repeat	Method
GGTGCTCACGAGTGAGCACCCTCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014008_3

>merge|NC_014008|3|423675-423765|CRISPRCasFinder
GGTGCTCACGAGTGAGCACCCTCCGAATTACGATGAACAGTCGGCTACAAAGGATTGGTGATGATTGGTGCTCAAGAGTGAGCACCCTCCG

>NC_014008|3|3|423675-423765|CRISPRCasFinder
GGTGCTCACGAGTGAGCACCCTCCG	AATTACGATGAACAGTCGGCTACAAAGGATTGGTGATGATT
GGTGCTCAAGAGTGAGCACCCTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014008.1\|WP_013042099.1\|410305_412036_+\|sulfite-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|273882
NC_014008.1\|WP_013042106.1\|417642_419205_+\|DUF4445-domain-containing-protein	unknown	unknown	gnl\|CDD\|379651
NC_014008.1\|WP_013042107.1\|419613_420027_-\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013042116.1\|433004_433862_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NC_014008.1\|WP_013042102.1\|413838_414468_+\|cobalamin-binding-protein	unknown	unknown	gnl\|CDD\|239021
NC_014008.1\|WP_013042103.1\|414488_415859_+\|uroporphyrinogen-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|239548
NC_014008.1\|WP_013042105.1\|416934_417642_+\|DUF1638-domain-containing-protein	unknown	unknown	gnl\|CDD\|377918
NC_014008.1\|WP_013042108.1\|420026_420866_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|380381
NC_014008.1\|WP_148216430.1\|434014_435607_+\|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl\|CDD\|293763
NC_014008.1\|WP_013042104.1\|416015_416933_+\|cobalamin-synthesis-protein-P47K	unknown	unknown	gnl\|CDD\|349766
NC_014008.1\|WP_013042120.1\|440328_442305_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225121
NC_014008.1\|WP_013042113.1\|427621_428428_+\|PEP-CTERM-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|131644
NC_014008.1\|WP_013042111.1\|423827_424850_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013042114.1\|428810_429704_-\|beta-agarase	unknown	unknown	gnl\|CDD\|185687
NC_014008.1\|WP_013042118.1\|435660_438051_+\|DUF4982-domain-containing-protein	unknown	unknown	gnl\|CDD\|225789
NC_014008.1\|WP_013042119.1\|438047_440138_+\|beta-galactosidase	unknown	unknown	unknown
NC_014008.1\|WP_169305283.1\|425051_427448_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380485
NC_014008.1\|WP_013042109.1\|420978_422493_+\|fucose-isomerase	unknown	unknown	gnl\|CDD\|238323
NC_014008.1\|WP_013042115.1\|430135_432502_-\|glycoside-hydrolase-family-2	unknown	unknown	gnl\|CDD\|225789
NC_014008.1\|WP_013042101.1\|412810_413833_+\|uroporphyrinogen-III-decarboxylase	unknown	unknown	gnl\|CDD\|239548

Protein	Function_ID	Function_description	E-value
NC_014008.1\|WP_013042099.1\|410305_412036_+\|sulfite-reductase-subunit-alpha	gnl\|CDD\|273882	TIGR01931, Sulfite_reductase_flavoprotein_alpha-component, sulfite reductase [NADPH] flavoprotein, alpha-component. This model describes an NADPH-dependent sulfite reductase flavoprotein subunit. Most members of this family are found in Cys biosynthesis gene clusters. The closest homologs below the trusted cutoff are designated as subunits nitrate reductase.	0
NC_014008.1\|WP_013042106.1\|417642_419205_+\|DUF4445-domain-containing-protein	gnl\|CDD\|379651	pfam14574, DUF4445, Domain of unknown function (DUF4445). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 525 and 664 amino acids in length. The family is found in association with pfam00111.	5.27953e-59
NC_014008.1\|WP_013042109.1\|420978_422493_+\|fucose-isomerase	gnl\|CDD\|238323	cd00578, L-fuc_L-ara-isomerases, L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose in glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in various oligo- and polysaccharides in mammals, bacteria and plants. AI catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion to D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon source. AI can also convert D-galactose to D-tagatose at elevated temperatures in the presence of divalent metal ions. D-tagatose, rarely found in nature, is of commercial interest as a low-calorie sugar substitute.	3.86784e-40
NC_014008.1\|WP_013042116.1\|433004_433862_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	2.02677e-14
NC_014008.1\|WP_013042102.1\|413838_414468_+\|cobalamin-binding-protein	gnl\|CDD\|239021	cd02070, corrinoid_protein_B12-BD, B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or monomethylamine, which is initiated by a series of corrinoid-dependent methyltransferases.	4.98484e-73
NC_014008.1\|WP_013042103.1\|414488_415859_+\|uroporphyrinogen-decarboxylase-family-protein	gnl\|CDD\|239548	cd03465, URO-D_like, The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, an important branching point of the tetrapyrrole biosynthetic pathway. The methyltransferases represented here are important for ability of methanogenic organisms to use other compounds than carbon dioxide for reduction to methane.	1.09029e-58
NC_014008.1\|WP_013042105.1\|416934_417642_+\|DUF1638-domain-containing-protein	gnl\|CDD\|377918	pfam07796, DUF1638, Protein of unknown function (DUF1638). This family contains sequences covering an approximately 270 amino acid stretch of a group of hypothetical proteins. These proteins are expressed by archaeal species of the Methanosarcina genus.	2.71283e-46
NC_014008.1\|WP_013042108.1\|420026_420866_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|380381	cd06976, cupin_MtlR-like_N, AraC/XylS family transcriptional regulators similar to MtlR, N-terminal cupin domain. MtlR is a Pseudomonas fluorescens protein that acts as a transcriptional regulator of the mannitol utilization genes. It has an N-terminal cupin domain (represented by this alignment) and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	4.33379e-27
NC_014008.1\|WP_148216430.1\|434014_435607_+\|sulfatase-like-hydrolase/transferase	gnl\|CDD\|293763	cd16144, ARS_like, uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	5.9663e-110
NC_014008.1\|WP_013042104.1\|416015_416933_+\|cobalamin-synthesis-protein-P47K	gnl\|CDD\|349766	cd03112, CobW-like, cobalamin synthesis protein CobW. The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterize it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K.	4.02299e-45
NC_014008.1\|WP_013042120.1\|440328_442305_+\|MFS-transporter	gnl\|CDD\|225121	COG2211, MelB, Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism].	1.51004e-61
NC_014008.1\|WP_013042113.1\|427621_428428_+\|PEP-CTERM-sorting-domain-containing-protein	gnl\|CDD\|131644	TIGR02595, conserved_hypothetical_protein, PEP-CTERM protein-sorting domain. This model describes a 25-residue domain that includes a near-invariant Pro-Glu-Pro (PEP) motif, a thirteen residue strongly hydrophobic sequence likely to span the membrane, and a five-residue strongly basic motif that often contains four Arg residues. In nearly every case, this motif is found within nine residues, and usually within five residues, of the extreme C-terminus of the protein. Proteins with this motif typically have signal sequences at the N-terminus. This region appears many times per genome or not at all, and co-occurs in genomes with a proposed protein-sorting integral membrane protein we designate exosortase (see TIGR02602). PEP-CTERM proteins frequently are poorly conserved, Ser/Thr-rich proteins and may become extensively modified proteinaceous constituents of extracellular material in bacterial biofilms. [Cell envelope, Surface structures].	0.000473662
NC_014008.1\|WP_013042114.1\|428810_429704_-\|beta-agarase	gnl\|CDD\|185687	cd02178, GH16_beta_agarase, Beta-agarase, member of glycosyl hydrolase family 16. Beta-agarase is a glycosyl hydrolase family 16 (GH16) member that hydrolyzes the internal beta-1,4-linkage of agarose, a hydrophilic polysaccharide found in the cell wall of Rhodophyceaea, marine red algae. Agarose is a linear chain of galactose units linked by alternating L-alpha-1,3- and D-beta-1,4-linkages that are additionally modified by a 3,6-anhydro-bridge. Agarose forms thermo-reversible gels that are widely used in the food industry or as a laboratory medium. While beta-agarases are also found in two other families derived from the sequence-based classification of glycosyl hydrolases (GH50, and GH86) the GH16 members are most abundant. This domain adopts a curved beta-sandwich conformation, with a tunnel-shaped active site cavity, referred to as a jellyroll fold.	8.76111e-93
NC_014008.1\|WP_013042118.1\|435660_438051_+\|DUF4982-domain-containing-protein	gnl\|CDD\|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	1.57049e-63
NC_014008.1\|WP_169305283.1\|425051_427448_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|380485	cd01543, PBP1_XylR, ligand-binding domain of DNA transcription repressor specific for xylose (XylR). Ligand-binding domain of DNA transcription repressor specific for xylose (XylR), a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of XylR is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	5.01468e-50
NC_014008.1\|WP_013042115.1\|430135_432502_-\|glycoside-hydrolase-family-2	gnl\|CDD\|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	5.3352e-47
NC_014008.1\|WP_013042101.1\|412810_413833_+\|uroporphyrinogen-III-decarboxylase	gnl\|CDD\|239548	cd03465, URO-D_like, The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, an important branching point of the tetrapyrrole biosynthetic pathway. The methyltransferases represented here are important for ability of methanogenic organisms to use other compounds than carbon dioxide for reduction to methane.	1.6267e-29

>NC_014008.1|WP_013042109.1|420978_422493_+|fucose-isomerase
MLNTTLPPIPEKGVLNDIVAELVPPLAKREKSRLLIVACGVKIHFPWDKACERYETAYQVLSKTAADLPVEIVCAPEPFEDPAALCQLLDEELREGLAGIVLFHAAYTAGEIGSHLGRWLLDHKMPLLSWAWPEEGTGGPNEANSLTCQNFLLQMLKQMGVPYAWLHEAITDAAAPVLETFCRVVHAKDTFKHAKLLHAGGSRVTGFYDGEVDELEVMKTLGCRFDRMDLETVFQHAKKKFSDADVRRLKDVLVAHPSCGNVALPEEQILQTYRFGLGMLDLAAEHGYIGATVKSWPDLFDCYGCAIDGSVSMMNDVGFCVAEEGEMNGLLSSLALFLLSDGKAVPTMMDLSLWKQATNRLGIWHCGASPTRLLKPGTQFNATRHSILENGDPDTAVGLMLEFLLANGPVTVMRYMAPDAGKWFAFEGEFEDTPLDYRGTYGLFKATGEASLSQIMGTIFDAGLDHHWSVGYGHWMNELRMLNHFCGLTEIPLRESNLNYGLSR
>NC_014008.1|WP_013042108.1|420026_420866_-|helix-turn-helix-domain-containing-protein
MKMTLEKVSPDMQASFRCLEWDAKDFDSPHHFHPEIEITEILASKGERLVGDRFDSYQPGDLAMLGSNLPHRYKNWKSNRSHSRVIQFLPDAFGPGFFDLPEFRKVKQLFQDASRGLSFSAETRAAASSIIASIFKLPPGPQRLIQLIELLDLLSQDKEREALASHDFMAPEKAEQSERLQRILNYIDTHWQDKISLDEVSKVACLHPQSLSRYFRQHLRKTFQEYLIELRLSRAARELLETKRTIADIAYDCGFNNLANFNRSFLAHYSITPRDYRKK
>NC_014008.1|WP_013042107.1|419613_420027_-|hypothetical-protein
MSTPSNSPLTRIALLAGVAYFTCMAIAHFFSIKVPVLFIYYDTPFYAYQDKIIAFAVCAYIAVFYNASKHRQLVPTAIIVLALTVAGLSAVNLSEALAEVLEEGQGTLAYWLQTVAIAGYIGLLVICYRRDTHLHDH
>NC_014008.1|WP_013042106.1|417642_419205_+|DUF4445-domain-containing-protein
MNLTLQFEQANGTVRTDTVPVETSEQKLSELLDEQGVALNYRCGGQGLCKGCLVEDPECGYVRACQVQVGELKGPLRIPMNSQAISVLHGVTDFQVSTDCPLKVEPRAGVGMVLDIGTTTVAGSLWNLEQSSCLVAESIGNSQWRYGDNIVSRITYSLQHVDGLKQLNRSLLQDTLKPLVESLLKAAQLDRSAITECLVAANPTMLHMLSMDSLEGMAQFPFEIKYLSGRAIENPLKRLSGLEQMYLLPSMGPFVGSDITAGAIAAGMHERREGNELLIDFGTNGEILLRAREDYFATATAAGPAFEGGSLNCGAKASTGVVSKIDFKEDAWQLELIGRDATRATGISGAAYVDFIAKAHQLGLLNDFGRVDESSTRLESLAVSGVDQRVVRISDQLFVSEQDIAELLQAKAAIAAGIRSLLERAQIEADELDHIYISGGFGYHLNMQHVCAIGLLPTLDAQCYSVLGNGSLGGASLMLLDPKLKAIAERLAAETCSVELNQEPDFEDHYIDSLALGDFE
>NC_014008.1|WP_013042105.1|416934_417642_+|DUF1638-domain-containing-protein
MSTKVIACEVFRAELNILGVAEDQIQFLEMGLHDNPPVLTQRLQETIEVVDAEAGVDRILLAYGNCGSGTIGIRALRSTLVIPKAHDCIALFLGSNQRYESEQRRNAGSYYFTPGWLNGGRVPGPEREAWLRKTFVDKYEDDEDLEDLIEADRELFASYHSACFVDSMADQHCAQRCAQCAMDMNWRFRRLQGTLDWLKQLLDGPHLDERFLVVQPGQQIVASSVGDLMRAETDL
>NC_014008.1|WP_013042104.1|416015_416933_+|cobalamin-synthesis-protein-P47K
MIPVILVTGFLGSGKTTFLKSFARKHPQLRMVFLVNELAEVSVDGATLAETGLPSHSVVGGSLFCECKAGDFVRVMRESIAPMHATDPLDAVLIETSGMADPEAIGKLMGEHGLNQWFEINRIVTIVSPQSFLKLKDNLPVVERQVQHSDLIILNKIDLADEEQITETEAAVRALAPLAEQIRAQHADAIFEFTQPRDALPNEDLAPCSANPFSTQTWSFKGICRIEDMEAWLAQIPSYVMRAKGHLQTRSGWYLIEKTVDNCTVSSCDPQDESCVVFVVHDDYEGALNEWCRELTVEYSALNLL
>NC_014008.1|WP_013042103.1|414488_415859_+|uroporphyrinogen-decarboxylase-family-protein
MGNKANLFKALKGEATDQTPWVPFVGVHGGALIGVDATEYLQNADHIVNGMKAANDKYKPDGLPVVFDLQLEAEILGCQLAWAKETPPSVASHVLDDEYDIEGLPEFSVEKGRIPLVLDAIRRTKEAIGKDVALYGLLTGPLTLALHLRGDDVLLDMFDDEDEVPELFDYCADIANQMVKAYLDAGIDVIGVVDPMISQISPEHFSQYVAPPLNKIFDYTAEQGALSSLFVCGNATRNIEAMCQTNCDNISVDENVDMKVLAETCAQYGKSFGGNLQLTVVLLLGDSADAQKDALRCMDLSGGKPGFVLAPGCDLPYAVKPENLTVIADMVNDPYKIDVARSLPDKQSDDRFDDVVIPDYGNEAEVVVDVITLDSAGCAPCAYMLKAAQEAAKAYDKPVRVLEHKITGRDGLGYMTKLGATAIPSLCIDGQEQFASIIPEREALVGKMLAAADAKA
>NC_014008.1|WP_013042102.1|413838_414468_+|cobalamin-binding-protein
MNTLLEPLVEAIKIGKRKDAKRVTQEAIDANTNPQEILDALTLGMEDVGRRFKANEIFVPEVLVAARAMKTAMTLLEPLLAASGIEPDHAIVIGTVEGDLHDIGKNLVAMMLKGANFKVVDLGTDVKAEDFIKAADESGAKVIALSALLTTTMPAIRETVEKVKASGKDIKVMIGGAPVTQEFADEIAADGYSEEAASAVDLAKKLVAA
>NC_014008.1|WP_013042101.1|412810_413833_+|uroporphyrinogen-III-decarboxylase
MNKRDVVKAVLDGHTPPYTPWSFRFTEEPEAALCTHYGCEPKDLIEHTGCHILELGSPIGFFEDLGNDHYKDVFGVVWDRTKDKDIGMPASYQLEEPEDLDDYEFPNPLDPRFFEDIESRITQFPDRFRLFTLGFSLFERAWTLRSMEELLMDMIEEPEFVHELFTKIADYNIAQVTEALKYDIDAIYFGDDWGQQESLIMGYDKWKEFIYPQVKRMYAVAKAAGKYQFIHSCGDVDELFPDLIDIGLDCFNPFQPEALDVHAIHKEYNGRLSFWGGLSTQQTLPYKGKADVIEESERLIEMGRKGSYIFSPSHSVESDVPFENILAFIDCAKAQEIPTA
>NC_014008.1|WP_013042099.1|410305_412036_+|sulfite-reductase-subunit-alpha
MSTVPYIPDNAPFSEDQRAWLNGFLAGLYSEAPGGVATASAPAVPVTILYGSQTGTSEALSKQAAKQMKAANCEPKVLDMGDVSLDELAALENVLIITSTYGEGEAPDNAMSLHEALMADSAPSMAGVKYSVLGLGDSSYPDFCQCSKDFDSRLEALGAQRVAATVEVDGDPDDLFPQWIESVQGAFGDASAAPAVVEATEAVESGYTKKNPYAAKLLKSANLNQEGSSKATHHVEISLAGSGLDYEVGDALGVYPENNPALVAEIIEAAGFTADELAPLPDGSSAPIAEALAYSYDISTLTDAFLSAAARLSKHADLQALLADDEARKAYLSGRSVIDPIVDFEVKFPTPDYFVSTLKALQPRLYSISSSPKAHPGEVHLTVGKVSYESHGRAREGVCSNYLARHDGERAVKVYLHSNSAFRLPENDAAPVIMIGPGTGIAPFRAYLEEREARGAKGKNWLFFGDQHVASDFLYEAQVTDWLRSGHLAKLDTAFSRDQAEKIYVQDRMIQQAEELYAWLEEGGCVYVCGDASRMAKDVDAALHTVVEQAGGKSAEEAKAYVDAMKKAKRYLRDVY
>NC_014008.1|WP_013042111.1|423827_424850_+|hypothetical-protein
MKTLDQKLETLRQNPGANEFIIADAKDADMAWGIASPGATYPNSGDGRFISMNEFMEQMREMTASGLIDILLASNSVMTTLAHDEGLFDDSAVTPAIRANDTSDVWISRVANYRNLPSKPFRSAYIHEAQYGSLTAPVVGDPKVNLGLYSMTFNNDLEADYLSLQAFREFRCEAAEAGFDYFLEVFAPNVEDCGISADDIPTYVNDALVRALAGVGRKNWPKFLKIPYFGPKAMEELANYDNDLIVGILGGGSGTTYDAFKQLTEAKKYGARVALYGRKIKDAEHPLTFVKYLRDLSEDQLSAEEAVKAYHADLEGLGLKPKRDLNADMELTDPGLSYAS
>NC_014008.1|WP_169305283.1|425051_427448_+|substrate-binding-domain-containing-protein
MKIPCLLPSDDSLAPLRVGILANIKLAHGRNLLRGAIRYISERQLPVQVELMQWTAEWSVEALEGFDGIIAGVDELDPRLVPTDIPAAWIGGREVGADGPVLEVAHEAIGKVAAEALLEFGVVSFGYYDGMHDGHEIREGRSKRRFQGFCDCIEAVQSPLIPTRIERHGQEGFESLVRWLDQLPKPAGVFAFNDMGAMIVADACQVAGIRVPDEISVVGVDNDRLMCMLSKPYLTSVDPKADAVAFEAMHRLLQEISGLRTDELSGQPAEPVIYRRESTGGSSYLRTSVSRSFDTIRRVALDELTPAAVAGSVDRSLRRLEDDFRETLGETLQQAIINERVRRAKRQLRDSNDSFEKIAELLGLEVRNFRKHFSKVAGLNPGEYRSLFRGESVDLVRSPVEAESPEIIRICCLNNLDSLAARDFIRGAEHFLNGRSNVQLSLHVDTTLVVGRDASLKSERPPYEVYDGFICIPDVELSPEVIGGKPVLALEHQRPLARSGSLVFDSYEAGVLAAEHFLAKGYQDFAFCAIQPDWVSLASDADDEREDQRYRGFVETLLESGVSEGRISRASYVDGATLIAWLTQLPKPCALMAYNDVLASILLTQCHRHGIRVPEDLAVLGVDNDNLLGQLQHPALSSVAVSFERMGYVALQDLTRVIEGEVEELDALKMVQPWGVVERASTAGLACNDATLHQAVGFIHRHFREPISAEQIAEACGVSRRALEYQFKRLLQTSPRAYLEVERLSAARALLCQTQWTVEEVADELGFKSGSYFTQVFKRKVGVTPLDFRSGRAPIVAN
>NC_014008.1|WP_013042113.1|427621_428428_+|PEP-CTERM-sorting-domain-containing-protein
MKKVISLASLIALGGALHGQTYTTDFSAGEGYVNGNLSGQDGWLAQTQWQVDNSGSGTSGTAVGAFVRANYTGLQSTNVVGSTFTVSTTFSMASNFVATTPPDASWKRGIFYVDITSEVANSAPAGFGQTGLALNADNTTLDFLTAGGATINLGNATLYDGHTFVLTSTYTKTAADTYTVASSIDSLGDGAGAFVGSGTVVDATNGAASAVQGFFSAHPTAGPASGTDVYQGVNVDSFSATYVVPEPGTYALFAGALALGAVMIRRRK
>NC_014008.1|WP_013042114.1|428810_429704_-|beta-agarase
MKALLKSLPFLLHLASIPVFAASNDWDRIPIPVEPERGMRWKLIDPSDDFNYTARADKKTKRFEKRWTEGFINQWTGPGLTEWQADHSEVADGTLKIKVTRKPGHDRLVHAGCISSYYPVKYPLFIETRAKLSKLPTASCVWMLSQDSTQEIDVLEAYGSDRPDQEWFAQRLHLSHHVFIRNPFTDYQPKDDGSWHYDGTTWADDYVRVGVYWRDPWHLEYYINGKHVRTVSGKEIIDPHGYTDGTGLNKPMYVIINAENQEWRTDQDIEPTDQELADSERSTMLVDWVRIYQAVKR
>NC_014008.1|WP_013042115.1|430135_432502_-|glycoside-hydrolase-family-2
MSYRHEISLCGNHWKMQGIRPGQGVIEGFHELASEYQGTFFNWNQGCVPGDVYTDLQRAGEIDDPYFGRNFGRAKWVQELEWWYVTKFDTPEELKGKQISLCFEGVDYACEAWVNGTYLGKHEGMFSQFEFDVTHLVRFEKWYEGCNILMVKLSPPPRNHRNVMGRKFCFGGDYMPDVIPMGIWQPIKVRATGRQRIEKTRIESKLTDDGANVSIEIDVRSKSDCPADIKLDLSLNGENFESDAITHSVHARVAPGANTVRVEIPVKNAKLWWPWDMGDQNLYELTVDLSKDGEGQDTHKEVFGIRELTMARNPGFTEEEVENDWTFMINGKRHFLRSTCWSGPPSMLYGRNRDEKYDLRLNMVKEANINNLRIFGWHPPEVPYFYELCNRLGITVWTNFCFATQAYKATPEVFHPAVDECVQIVEQRRNHPCAIMFMGGEEVFFSNAHAESDNKYIMESIGDAVRKVTNIPYAVASPMSGPFGQALGYKPKESTHANEHYYGAGHMLMEDYYTSLDYCVVPELTAASAPSVESLKKFIPENELWPMGPSWGYHWADIDILKVLNVEVFGELRCDSLEDFVEGTQTAHGIIAQFALEHFRRRKPRVSCVSLCHFMTHMPDIKWGIIDYYGEKKIAFDYVKRAYQPLLVSLEYTKRRWNSGKDFDGGLWVVNDEFTAHKGLTLKWTVTNAKGEVVQDDSIQIDVEPDSSKEFHRVQCPVEGEANETFKVFMQLISAEGEVLSENWHTLLVGDQDEAKQYCVEMHEKVTASANSYGKSYYRYFPELWDFE
>NC_014008.1|WP_013042116.1|433004_433862_+|AraC-family-transcriptional-regulator
MQLPQESEVVHWIDTPTPIGELVIAGVFMTNENWGLKEMRSLEFYSMALILEGGGIYRDETGVEMSVQAGDCIIVEPGLQHQYGCEAGGTWKEVYFCFKGSAFDDWRRSDRFRDRRIFNLDNVDFWSPRWFRIVKSRPRNFFEVVATLTDVHLLINQVVAGEQVDWSFEERLEASKQHLQSWPPNTTIDWDLIAGECGCSYETWRKAFSKQYDISPARFRRNALMRQAGRLMTRSNLSNEELADQFGCSDGFHFSKLFKSVMGLSPQEFRKQLTSDHTKSVDVHD
>NC_014008.1|WP_148216430.1|434014_435607_+|sulfatase-like-hydrolase/transferase
MIMTDDSGYTDLGCYGGEIETPNLDRLAEHGMRLSNFYTNGRCSPTRASLLTGMECGKVGFGGGALGDWMREMPEPARRGRLSDEVPTIAELLRADGYRTMMSGKWHLGGSLMKFNKGAQKVWKDLHPGWELTDEEIEADFNALPSQRGFDDYFGIYSAQDSFFFKEGQNHPFMEGNERARLEYSHDYTVHCYPSKPGSRYSENHGKSGPVFHATDGVTDRAIEMIETASKDAAPFFLYVAYRAPHRPWQAPESLVQKYLPKYENLRETQLARVQGLKAEGLFPEDGTYKPSWIPQDVDTFRRQLAIHSAMIDSVDQNVGRLMQSLVETEELDNTLVLFFSDNGSVSTLNEYMNAPYRGSKALVWEGGLKTHCIAYWKGKIQPASISHDQVWIGDWMPTVLELAGVEYPAEFRGQAIDPMDGRSVVQVLKGNSIEPHDTLYFNDKGQQSVIFKGRWKLLIEPGWYLQTSAKPGTAYELYDLHADPSESVNLAKQHPEMVQRLERIAKDRVESQGITDYETVIEVRPRDPY
>NC_014008.1|WP_013042118.1|435660_438051_+|DUF4982-domain-containing-protein
MKFVESPRTVVALAQDWRFYLGDEAAAAAADFDHSAWRTVSVPHDWSVEASFSETLEGATGYLPGGIGWYRKTFTPLGTDKTYLHFDGVYNNSTVYLNGEKLGDHPYGYSPFYFDISDKLVEGENVIAVRVDHSRYCDSRWYTGSGIYRKVELIGAAKTHVPMWGSFVTTPEITDEKAVVQLELEVANAVGGQTLKTEIFDPSGELVASASAELSTQVVQQLEVAQPKLWHVGQGNLYQAVCTLLEGETVLDSYRTTFGIRSFKFDADKGFFLNGENMKIKGVCLHHDGGCVGAAVPDDVWRRRFETLMAGGCNAIRIAHNPGSVDFLKLCDEMGLLVQDEFFDEWDNPKDKRKNMNEQHDDYISRGYTEHFQEWAERDLKDVMRSHRNHPSIFQWSIGNEIEWTYPRNAEATGFFNADWSGNYFWEQPPHSIDEIKRLLSELPRGEYDIGETAQKLSKWTKELDTTRPVIANCILPSSSYLSGYADALDIIGFSYRRVIYDYGHEHYPHLPLMGTENLGQWHDWKAIEERDHVSGTFLWTGIDYMGEVNEQWPKKSLDSGLLDTAGFEKGSYHMMKVLWSDEPHVHLTTQTLEKSPYDYDAETGFIGEADADAWQQKTWIWHDVNTHWNYREGELLAVEVYSNCERVELFLNGESLGVKQLADFEDHIYKWAVPFAAGKLEARGIGAEAVLETAGEATAIQLEVDGSHVIAQIVDAHGLPVKTDERELRFELQGDARILGLDNGHPKSVQDFQSDRIRTSQGRCLMVASEALEGCEVRVSSDGLIAAKLGGEALV
>NC_014008.1|WP_013042119.1|438047_440138_+|beta-galactosidase
MKRRLLIAACVSALAVILTPSAQAVQLVRLTGDQIHSKVEYTDTQILAYEKDGVLVRSGGKEEWPNIAFRALDLPWDLSGYATVKVDLVNLGSAPLFLGIRLDSKSASETETPQHAQGFDLLQPAERRTISIRLAAEDWVFDEPLDLVGMRRAPGVPLMDVAQVDQIQVFAGHMKGPGLFKISNIRAEGALKTVSSKDFLPFVDQYGQYKHEDWRGKIHNDAEFAATLKAELADLAANPAPKEWGTFGGWTAGPKLEATGFFRVQKVAGKWWFVDPEGYLFWSNGPTCLNAEFGYTGVQGREHYFDNMPSSETGPFAKFYQPCGWAPHGFYADKVPFTQFKFYQANLFRKYGDDWRADFEDMAHRRLKSWGMNTVANWATPSLYKQQRTPYVANFFITGNRVLEGSAGYWGQFHDVFDPSFRQVIRKEMKARAFESKDPWCMGFYVDNELSWGYDGMSLSVATLQSPANQVAKQVFVQDLQVKYRTIEQLNLAWGSAFASWQALLDSRDAPDMDRAGHDLKQFYKKTADTYFSTIRDELKAAAPNHLYLGCRFAWVNDPVAISAAEFCDVVSYNKYEHSLRSLHLPYHIDRPMIIGEYHFGSTDRGHFHPGLREAPNQLLRAAKFKDYIESALENPQMVGVHWFQYVDEHIAGRADEENYNVGLVDICDTPYPEMVDAMREVAETLYTHRYAEETE
>NC_014008.1|WP_013042120.1|440328_442305_+|MFS-transporter
MSDASKAVAETDIEKTKPEDVVPVREKIAYSMGVVSDHYANVCLAWIFMTPFFVDFLGLGASVIGWALGAARLWDAVTDPLAGRLSDACKSKYGRRKPFIFVGAILTGLMFPVIWMVPESWSTTAITIYLFVALMIFYSTYSIFSVPYEALGAELTPDYRERSKIFVVRKYVQETFNLGIVWIFPLAAWIAKEFFEGDNVQGIRSVSWLIAAIIIIGGILPAIFNKERYKDIAVKEGAGGFLDGIKALASNKPLLMVVGIIAVYLFAIMATANLAYFVNVYYIFEGDVLKGAALGGFDGTLRFFFALGAAYVISQMTDKVDKHKIMMASVIILMIAFVGMYFTTIPGRPILALSMKPLVSIGECGFWVLILSMRADVCDWDEYKTGTRNEGMVAAITNWCNKIAMTIAIVASGYSLQYIVKFDSKLLTEDVRAEIKVEADAGFAAIESDPAAKLAFTTQLQDKKLEAAREDYGKEAETNYEELEGESAVTLDAYTQEYVAGKMAEAESELIAEAKTEADALTVKSYASLLEDWKEDEIMADVKARAEVEYAAISDERKQGDVLAAYDFPLSFFLNSLLNSFRDKPYTLDMHVDTLKRRVVMDQQSPGTMERLRFLYCIPQAGALLICLVLLWKYPLTKKKMMEIRAELEARRGETAHD

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Crispr_ID: NC_014008_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014008_4

900463-900586

Orphan

Consensus_repeat	Method
ACACGGCTGGGGACAGCCGTGGCTACAACAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014008_4

>merge|NC_014008|4|900463-900586|CRISPRCasFinder
ACACGGCTGGGGACAGCCGTGGCTACAACAGCACTCTAATCCAAGGATGTAGCCGCCCCATCCTCAGGGGCGTTCTTGGTTACTGCGTACTTACACGGCTGGGGACAGCCGTGGCTACAACAGC

>NC_014008|4|4|900463-900586|CRISPRCasFinder
ACACGGCTGGGGACAGCCGTGGCTACAACAGC	ACTCTAATCCAAGGATGTAGCCGCCCCATCCTCAGGGGCGTTCTTGGTTACTGCGTACTT
ACACGGCTGGGGACAGCCGTGGCTACAACAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014008.1\|WP_013042451.1\|911702_913067_-\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NC_014008.1\|WP_013042442.1\|900862_901276_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NC_014008.1\|WP_148216305.1\|891164_891530_-\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_041744804.1\|892381_894103_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240291
NC_014008.1\|WP_013042439.1\|897155_898388_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_014008.1\|WP_013042432.1\|886244_888242_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_014008.1\|WP_148216304.1\|888344_889703_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013042438.1\|896199_896913_-\|L-rhamnose-mutarotase	unknown	unknown	gnl\|CDD\|377501
NC_014008.1\|WP_041744805.1\|904557_907044_+\|DNA-gyrase-subunit-A	unknown	unknown	gnl\|CDD\|235502
NC_014008.1\|WP_013042440.1\|898406_898805_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NC_014008.1\|WP_169305295.1\|889749_891168_+\|isochorismate-synthase	unknown	unknown	gnl\|CDD\|224091
NC_014008.1\|WP_013042450.1\|909987_911655_-\|glutamine--tRNA-ligase/YqeY-domain-fusion-protein	unknown	unknown	gnl\|CDD\|235424
NC_014008.1\|WP_013042447.1\|907861_908290_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350245
NC_014008.1\|WP_013042444.1\|904028_904454_+\|GxxExxY-protein	unknown	unknown	gnl\|CDD\|275083
NC_014008.1\|WP_013042452.1\|913256_914786_+\|conjugal-transfer-protein-TraF	unknown	unknown	gnl\|CDD\|372693
NC_014008.1\|WP_013042449.1\|908816_909968_-\|galactokinase	unknown	unknown	gnl\|CDD\|223231
NC_014008.1\|WP_013042443.1\|901456_903997_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	unknown	unknown	gnl\|CDD\|237860
NC_014008.1\|WP_013042446.1\|907610_907865_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013042437.1\|894362_896183_-\|DUF5060-domain-containing-protein	unknown	unknown	gnl\|CDD\|379863
NC_014008.1\|WP_013042441.1\|898890_900423_+\|4-alpha-glucanotransferase	unknown	unknown	gnl\|CDD\|237738

Protein	Function_ID	Function_description	E-value
NC_014008.1\|WP_013042451.1\|911702_913067_-\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NC_014008.1\|WP_013042441.1\|898890_900423_+\|4-alpha-glucanotransferase	gnl\|CDD\|237738	PRK14508, PRK14508, 4-alpha-glucanotransferase; Provisional.	0
NC_014008.1\|WP_041744804.1\|892381_894103_+\|hypothetical-protein	gnl\|CDD\|240291	PTZ00146, PTZ00146, fibrillarin; Provisional.	0.000350999
NC_014008.1\|WP_013042439.1\|897155_898388_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.81094e-30
NC_014008.1\|WP_013042432.1\|886244_888242_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	3.49156e-162
NC_014008.1\|WP_013042438.1\|896199_896913_-\|L-rhamnose-mutarotase	gnl\|CDD\|377501	pfam05336, rhaM, L-rhamnose mutarotase. This family contains L-rhamnose mutarotase which is a glycosyl hydrolase that converts the monosaccharide L-rhamnopyranose from the alpha to the beta stereoisomer. In Escherichia coli this enzyme is the product of the rhaM gene (also known as yiiL). The tertiary structure has been solved, in complex with L-rhamnose, and the catalytic mechanism determined. His22 is the proton donor. The enzyme naturally exists as a dimer.	9.25022e-11
NC_014008.1\|WP_013042442.1\|900862_901276_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	1.80991e-29
NC_014008.1\|WP_041744805.1\|904557_907044_+\|DNA-gyrase-subunit-A	gnl\|CDD\|235502	PRK05560, PRK05560, DNA gyrase subunit A; Validated.	0
NC_014008.1\|WP_013042440.1\|898406_898805_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	4.50408e-20
NC_014008.1\|WP_169305295.1\|889749_891168_+\|isochorismate-synthase	gnl\|CDD\|224091	COG1169, MenF, Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	1.29726e-105
NC_014008.1\|WP_013042437.1\|894362_896183_-\|DUF5060-domain-containing-protein	gnl\|CDD\|379863	pfam16586, DUF5060, Domain of unknown function (DUF5060). This is the N-terminal domain of a putative glycoside hydrolase, DUF4038. It is found in a number of different bacterial orders.	1.78603e-21
NC_014008.1\|WP_013042450.1\|909987_911655_-\|glutamine--tRNA-ligase/YqeY-domain-fusion-protein	gnl\|CDD\|235424	PRK05347, PRK05347, glutaminyl-tRNA synthetase; Provisional.	0
NC_014008.1\|WP_013042447.1\|907861_908290_+\|PIN-domain-containing-protein	gnl\|CDD\|350245	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins. This subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC25, VapC29, VapC33, VapC37, and VapC39 toxins. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	6.81666e-33
NC_014008.1\|WP_013042444.1\|904028_904454_+\|GxxExxY-protein	gnl\|CDD\|275083	TIGR04256, conserved_hypothetical_protein, GxxExxY protein. Members of this protein family average about 130 residues in length and include an almost perfectly conserved motif GxxExxY. Members occur in a wide range of prokaryotes, including Proteobacteria, Perrucomicrobia, Cyanobacteria, Bacteriodetes, Archaea, etc.	3.29786e-55
NC_014008.1\|WP_013042452.1\|913256_914786_+\|conjugal-transfer-protein-TraF	gnl\|CDD\|372693	pfam13729, TraF_2, F plasmid transfer operon, TraF, protein.	8.28658e-14
NC_014008.1\|WP_013042449.1\|908816_909968_-\|galactokinase	gnl\|CDD\|223231	COG0153, GalK, Galactokinase [Carbohydrate transport and metabolism].	2.69766e-104
NC_014008.1\|WP_013042443.1\|901456_903997_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	gnl\|CDD\|237860	PRK14939, gyrB, DNA gyrase subunit B; Provisional.	0

>NC_014008.1|WP_013042441.1|898890_900423_+|4-alpha-glucanotransferase
MKTQYPLYNWLQDRSAGVLLHISSLPSSTGIGNFGTGAYRFVDFMQSSGFRVWQICPLGPTGFGDSPYQCFSAFAGNPYFIDLEPLIHEGLLHEDEIGALRALPHTETYYGELYEAFWPLMRLAHERFARSGADHVQDYGSLPSFRKEQAFWIEDFAHFMAFKEHFEGRCWLDWPASFRDHSKAMAKALPADLQAAVDAQVFYQYLFFAQLSKLRHYAQSKGVELMGDVPIFVALDSADVWSHRNLFQLKADGQPSAVAGVPPDLFSEDGQRWGNPLYAWEVHQADKFSWWLERIRSNLSFFDLVRLDHFRGFESYWSVPEQEVTARHGEWIQSPGLELFTAVKKTFPDAKFIAEDLGVVTEEVEQLCDQTGLPRMAILQFAFGDGSGNPFLPHNVGENYVVYSGTHDNETTVGWYANADSNTQDHVRRYLSVSSDEIAWDFTRAAIRSNAKLAVIPLQDLMSLGNEARFNEPGNPVGNWQWRYGQAELDRLQAESSGYLRDQLELFGRA
>NC_014008.1|WP_013042440.1|898406_898805_+|antibiotic-biosynthesis-monooxygenase
MKSLNQLFVLMLLVLGCGTQIGCQCVTAPCTEIPNDALKLVVTIQAEPGQRDFVQAELSKIIEPSLKDSGCLQYALFSDNENSDTLILIEAWESHAIWLEHMEQPHVKAFVTAIEGKVKDLHIYQLAYTAGR
>NC_014008.1|WP_013042439.1|897155_898388_+|signal-peptidase-I
MSNRRKLTKNAKELLHAAGKVYHYRKDLITEARLLELEQAVAEVQGMAKDKTSDLAGFEASMGRLDALLRKIGGQIYPKTFWSDNLEVILVAAIIVIGIRTFFFQPFIIPTNSMYPTYSGMNSVTYPLAADAAPSTPAKLLRLATLGARHHHLSSETAGLVTIPGHEIKGKFMPLRQEIPARKFGILPSKKWQYVVLVDGKPHTIDVPASFELQPVVAESFPKSRVKIGQFNGRRVQLLETGVKVAAGDSLLRFDVTLGDALFVDRISYHFKRPAVGDPFVFRTNKILNAVGQATGDYTPKYYIKRLAGEAGETLEIKDYQLLVNGEPRDEVEAFERNAVREGEYSGYINDRLMSAGRSMTVPDKHFVALGDNSANSADSRYYGFVPEESVVGKAIFIYYPFTKRWGVAE
>NC_014008.1|WP_013042438.1|896199_896913_-|L-rhamnose-mutarotase
MSPYENRLIAESFRRVALIALTNPDEISRLREQLSTRPESLEADALAQKGIRHLSFYEQRFDERNFLFVYFEMDELDQEKASEVVRASDPNWWAELESLLVSHPRASRESAPWQRAEFMNVVASNTVRDRSIGKAVGYAAGLHLDQELWYRTLHQTNWPGVIDQMFRSHLQNWTTFMLEYGDELILFTHSEYQGTDKAADDALMQADPVTQRWWKHTEPCLYSLETDGASWTEMNRY
>NC_014008.1|WP_013042437.1|894362_896183_-|DUF5060-domain-containing-protein
MKNTIRLTTLALLAAAQAAHAESIAEVSGSLRTWHKVTLSWNGPQTNELATPNPFTDYRLDVRFTHQQSGTSYLVPGYYAADGDAANTGADSGSVWRVHFAPDAIGNWDYAVSFRTGEAVAMAQHPQVGDGTHFDGDSGTLNIRPSAQKAPDLRAKGRLQYVGEHYLKFAASGEYFLKQGADAPENFLSYKGFDGDFKSDGINDHLVKDWEPHVQDWKDGDPSWADGQGKGIIGAVNYLASEGLNAFSFLTMNIEGDDRNVFPYTTYKERYRMDCSKLAQWEVVFEHADSKGMFLHFKTQETENECLLDNGDTGPMRRLYYRELVARFGHHLALNWNLGEENGKWDWPGHVKEHFQSTEQRQAMAQWFYDNDPYKHHLVIHNGQSPNDLLGDASKLTGFSLQTNLEDFANVPGTVASWIRKSAEAGKPWAVACDEPGDASHAIRPDDNAGSSHENGRRNALWGCLMNQGYGSEYYFGYKNAHSDLTCNDYRSRDKWWDYCRYALEFFHNHKVAIWELAPAHKLSSNSESWCLAKTGETYLIYIKDGATTNLDLSGDSGKFQVQWYDTRKGGSLLAGSEKKIKAGEAVSIGKPPYDPDRDWLVLVSK
>NC_014008.1|WP_041744804.1|892381_894103_+|hypothetical-protein
MADQSAENPQESSKKELDLTALSGLDFGPSWADGQGDSRKLAKKYDSAGDGRQRGKGSGRRAPSSRDRRAGGRPQRTPVGDGGDRSRGGPRRERGDRGGRGGPRREHKPFEPVVNVDLYPQDEAFDALVKRLTATARTYQLFEIAHLLLEKPERFVAVISNKKQAGEAEAAPLFFAVPGHIPFENEEDAINHVLTNHLDLFFEIEEIEVEAPKGSFQVVNRCGVTGELLGPPNYHRYQEFVQRHYSNRIHGMSFDRFQSKIESVKEQETIDAWVEAMKKGARYTLKERAEGEPESFESLEAVRHFLLSHRKDQVVGSGTSVRFAGRDVERMPRGVLRRSIETYVEAQQRFPLDTANNIRGRLRRHKFTVYKKGGKGISYVCAVKRKFRDSSTVFSDSIQALIEFLEKHPDLPATDLPKVYLGIDQQASADTPEKLAMAEESAQGAAATEAPAAEEGAETVEAKEAAVPNPDAMSAEDHAKLEALMIDLRWLITEGYVTEYGDGRLFAPAPMPEPKKKVEQAPVAEPEVAPASEAEPVVNEEPVAAATEPSDSGAPITAEPIASDAEADEPKAE
>NC_014008.1|WP_148216305.1|891164_891530_-|hypothetical-protein
MKALLYSLACACALPLSAHDQISIPQPLRIQVDESFKREVSPGRFADQWVATFKELRFSSTNRADVVLINADGDYVIENVYKIEQSEQSSLLVLTYRSGRRDYKAIISPAQIRMIRESDPD
>NC_014008.1|WP_169305295.1|889749_891168_+|isochorismate-synthase
MIPPSKLPQRDKASLCRFLEGCQTAARLKGRFQLASISLAVRHISPLAVLQSIYEPDELHFYVERATDDEAVAGAEAVVEARFTGPTRFAEVKAFAQELLENTIAIGDLDAAFTGPHFFTAFSFDDTVPDGSTFPAATVFVPRWQVSRSDGRYGAVANVRVDADSDIEQLVERVWGAYEKFAAFEYPDEELAEVSTMPATQVERREVSVDQFKQAVSTALDQIEAKAYEKVVLARSIELHADQDWQPLDALNRLRERFGGCFTFSFGGGQGRSFIGATPERLIKVRNGQLATDAIAGSAPRGATAREDAKFARELLESAKDLHEHACVRESILRRLESCGVSACAEAQPRLLPLPNVQHLRTRITAPASESVHLMDLVAELHPTPAVGGTPRAAAVSHIRELEKLDRGLFAGAIGWFDHRNEGEMIVGIRSALIDGAVARLYAGAGIVKGSDPRKELNETEIKLGAMLNALT
>NC_014008.1|WP_148216304.1|888344_889703_+|hypothetical-protein
MRLTSSRTIIAISICIALCAALGIWQFFAWLRTDEPKLDYSQLGLRERIQDPEVNGYTVMREFSLQYRMSQADEDLLLESFESDAGAVDWDAVQVLLEDQTELMETFRHAFGMGTFYFDEVNTPETMIPEIGILRDYVRLRILQSRFLRQTGAEACALDQLLEIQQDLNRYQQSGGALISLLVGISCKQLVAKEVFEQLDHCELTTEQGRFYANQFVDAMTVEHIQSAFKHEFHFASYCVHLIHDDPETLFQLVDADQEATAVGRAIYNGGVRYVLKPNRTINHFYRAYSEIIDQADLPAKQRKLDYNQELLADLGGPKRDHLLTRNPFGRILLAILFPTVEAVVAKTDQFRAEFAALQLAIALNAYYTESGELPDTLAQLVPEFITALPVDPYDGEPMRYSKEQKIIYSVGVDFIDQGGSRLPSRMLATENELDCAEEDETEPTYHLSFVP
>NC_014008.1|WP_013042432.1|886244_888242_-|ATP-dependent-helicase
MFDETESFSSAFAPIDFRAELNDEQYAAVTADPGPALVLAGAGSGKTRTLTYRVAYLLHAGVQAHEILLLTFTNKAAREMLERVEDLTAVSRRQLWGGTFHSIAQRILRQHGEHIGLKRHYTILDESEAESLLKNAINAVDPKFIKGKNNPKPKVVANMISYARNTCRSVYEEADDHFPFLDDMAQKIADIYTKYQAMKLEQQVVDYDDLLELLLKLLREHPDVAAIYQQRFKHILVDEFQDTNRLQSEIVDLIGVNHQIMAVGDDAQCIYTWRGADFDNIMRFNDRHPEAQIHKIETNYRSTPEILDYANAVLGNQPAGKGYFKELRPVKESGAKPYFVPIMDARGQAQFIIQRISALVDEGHNLSDIAILYRAHYHAMDLQMELSRQNIDYQITSGVRFFEQAHIKDFSAQLRFASNPADVSAFARFTTLLPKIGPKSAERIHAFTKSLAEKEQTNFCDMLTSEAVLKKVPNDAKEEWPSLAETIRELSNALSEQRPSDVVQLGLDGWYGSYIREIYPNWTEREDDLQSLISFASRYETMEELLAQLVLLASESNERGPDELKHCLRLTTIHQAKGLEFPIVFVIGLADGLFPLQRTIDDGDLEEERRLYYVAVTRAMDELYLSYPMLNQKGNSVMRMNPSRFVQEIDTSRYETLRVAPTRSW
>NC_014008.1|WP_013042442.1|900862_901276_-|Rrf2-family-transcriptional-regulator
MKLSHKLEYACRVLAQLGRSYGQDKLAHIDTLADAEKIPANYLVQILNELRTAGLITSKRGKQGGYALSREPSKIQLSAIVQAVDAELLEQHLSSDGHSGERVATIWGDIAKNFEEQVGRYTLEDMIVSDGEQMYYI
>NC_014008.1|WP_013042443.1|901456_903997_+|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B
MSDQELPENSTADSAQKNAQPDVYDSSKIQKLEGLEGVRKRPDMYIGDTNERGLHHCVFEIVDNSIDEALAGHCSQITVSIHNDGSCSIEDDGRGIPVDIHPKYQIPALELVMTNLHAGGKFGKGAYQVSGGLHGVGAKCVNAVSEWFEVEVRRDGKVHKMEFSRGLTTQKMKIIGETKRTGTRIAFSPDPQIFEATREFKYELLGKRLRELAFLNPGIKIIFTDERVSKTEEFIFKDGIAEYVSFLNENKNIIHPDPISFHGEAPTPNPDLDANIVVDIAFQYNDGYSDQIYSYANSIHNIEGGTHLSGFRTALTRVINAYAKQNGLLKDKDPNLSGDDAREGLTAVISVKVPEPRFEGQTKTKLSNGEVDGIVQKITGEELKFYFETNPQVAKKLIDKCLNAARAREAARKARETVRKGALSTGGLPGKLADCSSKDPSVSELYIVEGDSAGGSAKQGRDRATQAILPIRGKLLNVEKARLDKVLGNNEIRSLITAVGTGIGDHEGDGAFDVSKARYHKIILMTDADVDGAHIMTLLLTFLFRQMKGLIEAGYVYIAQPPLYKIKRKRREQYVDNDPQLNRILLELGSEDVNLVRLRDQKDLSGEKIDELVESLSRLEMIGRGVTRYGCDFATYLDQHTDGTYELPRYIVRVRTGNEEEFHFLKDDDARIEFHSEFGVGDEDISGTVVREHVTDEGIKLQQRISLHEIFESTEMTKLLNELASAGMDVHQFSKSEEARYHLVEHKGDEKKENTIELHSIIELVDNIRAIGRRGLSIQRYKGLGEMNPKQLFETTMDPKSRRLLKVDIADAAAADGIFSMLMGEDVPSRRAFIEDNALNVSHLDV
>NC_014008.1|WP_013042444.1|904028_904454_+|GxxExxY-protein
MKDVSKNQDIYPELTHEVIAAAIEVHRALGPGLLESIYERCLIHELQLRGHNVAQQAQVDITYKDLVFEESLRCDLIIDHKLLVELKSVEATTPVHKAQTLSYLRLLQFPVGLLINFNVTRLTEGVSRLYNKHTSALSSSV
>NC_014008.1|WP_041744805.1|904557_907044_+|DNA-gyrase-subunit-A
MRAQATSITDIMQTAYIDYSMSVIVSRALPDARDGFKPVQRRILYAMLREGLLHNRPFDKCAGVVGEVLKNYHPHGDSSVYDTLVRLAQDWVMRYPLIVPQGNFGSIDGDSPAAYRYTECKLQAIAEDCLKDIDEDTVDFVPNYKESTTEPSVLPAALPNLLMNGSTGIAVGMTTNIPPHNLNEIIDAACAIIDNPKIELDELIQFIPGPDFPGGGFIHGKSGIESYLKTGRGIVRTRGVAEVVENKGKEEIIISAIPYNVNRASLVMRIAELIKEKAIEGISDLRDESTEETRIVIELKRGAIPRVIINQLYKSTALESSFGVILLALDNRRPKQMNIKEMLTCYIDHRREVIYRRTAFRLRKAEARAHILEGYKIALDNMDDFVKIIRASKNREEAKVSLMAKYPLTEIQTNAILELRLYQLTGLERDKIEEEYRKLMELIGELKDILENESRLLEVIKEELGEMKEKYGNPRRSQVIAVDGDISMEDLVPNEGCMITVTHKGFIKRTSLDEYRSQKRGGKGVIGSGQYEDDFVEHLFTASTHDYVMCFMNSGRVYVEKVYHIPEGSRTAKGRAMANVFELQEGEKIAAMICVKDFDESAQSIVLATENGVTKKTKLSDFRNHRKGGIIGINIDEGDNLVGARLTSGEDDIILVTSNAQSIRFPETDLRDQGRNTRGVRGIKLKSENDKVVAIEIVDDEAKLLIAGANGLGKRTEFSEYRQQSRGGSGIIAIKSDKVAGALSVTDADEIMMFTLKGQAVRSPIDTVRVTGRAASGVKLVNLGNKDELIGISKVIASEEDEAGEGEDAVEGEAPDEVATEAPEATEE
>NC_014008.1|WP_013042446.1|907610_907865_+|hypothetical-protein
MRTTIDIKDAILDALKERAHLEKRPMTKVVNDVLEKGLAAPTKQTKKVRLKTYGLGIRPAFRGMSLNQVYDQLETEDHLRVAEE
>NC_014008.1|WP_013042447.1|907861_908290_+|PIN-domain-containing-protein
MILPDANLLIYAHDHSSRDHATAKDWWETALSGSESIGIPWIVVLAFTRILTHPQICEAPLGVTQVRELVEQWFDSPQVRLIQTSNRALPVFFDLLEDAGMGGNLSTDALIAAHAREHSAVIYSCDRDFDRFMGIRWVNPLR
>NC_014008.1|WP_013042449.1|908816_909968_-|galactokinase
MPENTIALFKSAFSAVPEQLAFAPGRIEFIGNHTDYNGGLVMGAAVTEGITVGVSKRTDRKISLISDAAAQVVTSLDEIKPLEGDASWTNYPMGVTKVLLDAGMQMDVGYNIAVTSTLPAGAGMSSSAAFELATAYALAALYGYETDKAGFARIGRKAENDFVGMPCGILDQGVSAFGVFNSLVSIDCATETFSTKEMPTGGHFWIFNSNKKHALVDSAYADRFKECHDALAIVQKTYPDAETLSQVSEAQLRSCKDELGDLLFRRALHIVGENARVREVEAALKNSDLDAVGFAITASHHSSRDNFENSIEQLDFLVDTVTQMDNVYGARLTGGGFGGAIMAFTSAEFGQEQAEKVADAYKAKFGMDATIIHTRAGDGAHLL
>NC_014008.1|WP_013042450.1|909987_911655_-|glutamine--tRNA-ligase/YqeY-domain-fusion-protein
MSDAVEKPLDFIRQMVAADVAAGKHDGRVQTRFPPEPNGYLQIGHAKAICLNFEIAKENGGKCNLRFDDTNPEKESDEFVRAIQEDIQWLGYEWEKICFASDYFEQLFSWACQLIESGDAYVDELNAEQMRDYRGSLTEAGKNSPYRDRPAAESLDLFKRMRAGEFADGEKVLRAKIDMAHPNMNMRDPVMYRIKRMHHHRVGDAWCIYPSYDFTHGQSDSLEEVTHSLCSLEFEDHRPLYDWFIDKLGIFPSKQTEFARLNMTYCVVSKRKLRALVEGDFVEGWNDPRMPTLSGMRRRGYPAASIRNFCSTIGITKVPSTSDIALLEHAVRDELNRIAPRRMAVMNPLEIELTNWPENEVLEVEGVNNPEDESAGTRKIPFSKRILIEQDDFREEANRKFFRLKKGGEVRLRYAYIIKCDEVEKDAEGNITKLYCSVDLDTLNKNPEDRKVKGVIHWVSSQHAIKAPVRLFDRLFSVEKPEADKDKDFLDFVNPDSLSETTALCEPSLADLPIGTTCQFERIGYFCPDSQLSTAGSPVFNRTVGLRDSWAKKAK
>NC_014008.1|WP_013042451.1|911702_913067_-|glutamate--tRNA-ligase
MSEVRVRFAPSPTGFFHIGSARTALFNWLYARHTGGKFILRIEDTDKERNTDEALRVLIDGMRWLGLDWDEGPEVGGESGPYFQSERQSIYDEYLQKLKDAGRTYEKDGAIWFKLEGERYTEYDDFKKAEVEKVRTEPVVIDDAVRGRVERAEELDFVLVRKDGNPVFHLVNVVDDIAMGITHVIRGEDHLSNTSKHVELFKAFGVEPPKFAHIPLILKESGPGKMSKRDKGALIEEYESRGFLASAVRNYISLLGWNPKDDREKMEIEEIIELFDFPGINKGNARFDEKKLAALNAEYLRELNLGSFTFMAAPLLADAGIIDESTDEDYLQAVLGLCQPKARSLDTMGDMCAYFFKDEYSMDEKTAAKIAKKADPKELLAEILPILESTAFEADALKAALEAHAESKGAKVFAYFPALRFALSGQGGGPDLLPMLEVMGRDRVVSRVQAFING
>NC_014008.1|WP_013042452.1|913256_914786_+|conjugal-transfer-protein-TraF
MRRFAQIVSLLALSAPLLSLDAVIDDLTVSNARSSSMGGAGIAAVSGTSGVISNPAVLGFMARETPDDLDHFSLSEQRFGWDVLNAELGATLTGDLWTHIDFFREVDFGDFDLDSLQEPESVEELIRLSALLSTVDANDTIMVNATASSTVQIGHFAVGVRSFGQLSGWIEDVDLVNVGLQFGAAVLASELDDAMIAEGFDPTGYSLQVLSSDQAQALQDAAGLGVFNQDTLAYLDFKIADLVDSGALALGDVEDAVDGLIDVIENSDTVNQITSNQTTITGRGFLAVEVPISYGYAVNDNFSIGLTAKVILGRVYGTQVWVFNRDNDQILENTLDSYQDSVNLGIDLGMLYRTPSWQFALTGYNLNNPTFDGYDQKLTVNGTERTVRVQSVQLEPQVKAGAAWLPSRRLTLAGDIDLLQTDTLLQDYTVQRLSFGAEYDLSMVQLRLGTYKNIAESEIGWVLTGGLGFQLWALDVNAGGAVSIDDTVEYDSTDYPRTMRLFLSAGVQF

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Crispr_ID: NC_014008_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014008_5

1695901-1695995

Orphan

Consensus_repeat	Method
TCCGCTCCTCGGAACACGCTCAC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_014008_5

>merge|NC_014008|5|1695901-1695995|CRISPRCasFinder
TCCGCTCCTCGGAACACGCTCACTTTAACTTTCACTTGATCCGGTTCGCTTCGCGCCCGGTCATGTCGTCGCTCCGCTCCTCGCAACACGCTCAC

>NC_014008|5|5|1695901-1695995|CRISPRCasFinder
TCCGCTCCTCGGAACACGCTCAC	TTTAACTTTCACTTGATCCGGTTCGCTTCGCGCCCGGTCATGTCGTCGC
TCCGCTCCTCGCAACACGCTCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014008.1\|WP_013043085.1\|1690495_1691749_+\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|379065
NC_014008.1\|WP_041745726.1\|1705213_1706455_+\|pyrophosphate--fructose-6-phosphate-1-phosphotransferase	unknown	unknown	gnl\|CDD\|180620
NC_014008.1\|WP_013043091.1\|1697813_1698815_-\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240659
NC_014008.1\|WP_013043093.1\|1703143_1705042_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|238625
NC_014008.1\|WP_148216336.1\|1691774_1692737_-\|hexose-kinase	unknown	unknown	gnl\|CDD\|238570
NC_014008.1\|WP_013043087.1\|1692802_1695244_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|224125
NC_014008.1\|WP_013043096.1\|1707786_1709049_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|223727
NC_014008.1\|WP_013043090.1\|1696467_1697814_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_014008.1\|WP_013043082.1\|1685139_1687578_+\|RNB-domain-containing-ribonuclease	unknown	unknown	gnl\|CDD\|273947
NC_014008.1\|WP_013043097.1\|1709567_1710575_+\|pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_014008.1\|WP_013043092.1\|1699012_1702501_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013043088.1\|1695463_1695781_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_014008.1\|WP_013043080.1\|1683595_1684675_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369446
NC_014008.1\|WP_013043089.1\|1696012_1696399_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NC_014008.1\|WP_013043083.1\|1687593_1689420_+\|SLC13-family-permease	unknown	unknown	gnl\|CDD\|238535
NC_014008.1\|WP_013043079.1\|1681730_1683581_+\|type-IIA-DNA-topoisomerase-subunit-B	unknown	unknown	gnl\|CDD\|235501
NC_014008.1\|WP_013043095.1\|1706666_1707644_+\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|239584
NC_014008.1\|WP_013043081.1\|1684768_1684957_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_169305320.1\|1689394_1690444_-\|bile-acid:sodium-symporter	unknown	unknown	gnl\|CDD\|372642
NC_014008.1\|WP_013043098.1\|1710631_1711339_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225577

Protein	Function_ID	Function_description	E-value
NC_014008.1\|WP_013043085.1\|1690495_1691749_+\|MgtC/SapB-family-protein	gnl\|CDD\|379065	pfam13194, DUF4010, Domain of unknown function (DUF4010). This is a family of putative membrane proteins found in archaea and bacteria. It is sometimes found C terminal to pfam02308.	2.00166e-57
NC_014008.1\|WP_041745726.1\|1705213_1706455_+\|pyrophosphate--fructose-6-phosphate-1-phosphotransferase	gnl\|CDD\|180620	PRK06555, PRK06555, pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated.	0
NC_014008.1\|WP_013043091.1\|1697813_1698815_-\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240659	cd12183, LDH_like_2, D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains. D-Lactate dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate, and is a member of the 2-hydroxyacid dehydrogenase family. LDH is homologous to D-2-hydroxyisocaproic acid dehydrogenase (D-HicDH) and shares the 2-domain structure of formate dehydrogenase. D-2-hydroxyisocaproate dehydrogenase-like (HicDH) proteins are NAD-dependent members of the hydroxycarboxylate dehydrogenase family, and share the Rossmann fold typical of many NAD binding proteins. HicDH from Lactobacillus casei forms a monomer and catalyzes the reaction R-CO-COO(-) + NADH + H+ to R-COH-COO(-) + NAD+. D-HicDH, like the structurally distinct L-HicDH, exhibits low side-chain R specificity, accepting a wide range of 2-oxocarboxylic acid side chains. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain.	0
NC_014008.1\|WP_013043093.1\|1703143_1705042_+\|amidohydrolase	gnl\|CDD\|238625	cd01300, YtcJ_like, YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.	1.58434e-145
NC_014008.1\|WP_148216336.1\|1691774_1692737_-\|hexose-kinase	gnl\|CDD\|238570	cd01164, FruK_PfkB_like, 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.	8.31075e-88
NC_014008.1\|WP_013043087.1\|1692802_1695244_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|224125	COG1204, COG1204, Superfamily II helicase [General function prediction only].	1.92896e-44
NC_014008.1\|WP_013043096.1\|1707786_1709049_+\|FAD-dependent-monooxygenase	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	1.44557e-35
NC_014008.1\|WP_013043090.1\|1696467_1697814_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.80102e-08
NC_014008.1\|WP_013043082.1\|1685139_1687578_+\|RNB-domain-containing-ribonuclease	gnl\|CDD\|273947	TIGR02063, Ribonuclease_R, ribonuclease R. This family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans. [Transcription, Degradation of RNA].	0
NC_014008.1\|WP_013043097.1\|1709567_1710575_+\|pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	7.8452e-55
NC_014008.1\|WP_013043088.1\|1695463_1695781_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.11021e-19
NC_014008.1\|WP_013043080.1\|1683595_1684675_+\|hypothetical-protein	gnl\|CDD\|369446	pfam07642, BBP2, Putative beta-barrel porin-2, OmpL-like. bbp2. BBP2 is a family of putative porin proteins that are likely to be outer membrane beta barrel proteins porins.	1.21058e-07
NC_014008.1\|WP_013043089.1\|1696012_1696399_+\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	4.02122e-18
NC_014008.1\|WP_013043083.1\|1687593_1689420_+\|SLC13-family-permease	gnl\|CDD\|238535	cd01115, SLC13_permease, Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.	9.44259e-47
NC_014008.1\|WP_013043079.1\|1681730_1683581_+\|type-IIA-DNA-topoisomerase-subunit-B	gnl\|CDD\|235501	PRK05559, PRK05559, DNA topoisomerase IV subunit B; Reviewed.	0
NC_014008.1\|WP_013043095.1\|1706666_1707644_+\|fatty-acid-desaturase	gnl\|CDD\|239584	cd03507, Delta12-FADS-like, The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of organisms including higher plants, green algae, diatoms, nematodes, fungi, and bacteria. The expression of these proteins appears to be temperature dependent: decreases in temperature result in increased levels of fatty acid desaturation within membrane lipids subsequently altering cell membrane fluidity. An important enzyme for the production of polyunsaturates in plants is the oleate delta-12 desaturase (Arabidopsis FAD2) of the endoplasmic reticulum. This enzyme accepts l-acyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate and requires NADH:cytochrome b oxidoreductase, cytochrome b, and oxygen for activity. FAD2 converts oleate(18:1) to linoleate (18:2) and is closely related to oleate 12-hydroxylase which catalyzes the hydroxylation of oleate to ricinoleate. Plastid-bound desaturases (Arabidopsis delta-12 desaturase (FAD6), omega-3 desaturase (FAD8), omega-6 desaturase (FAD6)), as well as, the cyanobacterial thylakoid-bound FADSs require oxygen, ferredoxin, and ferredoxin oxidoreductase for activity. As in higher plants, the cyanobacteria delta-12 (DesA) and omega-3 (DesB) FADSs desaturate oleate (18:1) to linoleate (18:2) and linoleate (18:2) to linolenate (18:3), respectively. Omega-3 (DesB/FAD8) and omega-6 (DesD/FAD6) desaturases catalyze reactions that introduce a double bond between carbons three and four, and carbons six and seven, respectively, from the methyl end of fatty acids. As with other members of this superfamily, this domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain eight histidine residues: HXXXH, HXX(X)HH, and HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homologue, stearoyl CoA desaturase. Mutation of any one of four of these histidines in the Synechocystis delta-12 acyl-lipid desaturase resulted in complete inactivity.	7.77805e-34
NC_014008.1\|WP_169305320.1\|1689394_1690444_-\|bile-acid:sodium-symporter	gnl\|CDD\|372642	pfam13593, SBF_like, SBF-like CPA transporter family (DUF4137). These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, pfam01758.	7.86165e-70
NC_014008.1\|WP_013043098.1\|1710631_1711339_+\|hypothetical-protein	gnl\|CDD\|225577	COG3034, COG3034, Uncharacterized protein conserved in bacteria [Function unknown].	2.2256e-27

>NC_014008.1|WP_013043088.1|1695463_1695781_-|winged-helix-turn-helix-transcriptional-regulator
MTEQEAVEFGKAVGDLTRQRILRFCCCTPKSVGDIAKQVEVRQPTASHHLAILEKAKLVERDQHGKVVYYQVNQERMANCCGALMMNLAPEDSTTQAFQAHCCEC
>NC_014008.1|WP_013043087.1|1692802_1695244_+|DEAD/DEAH-box-helicase
MDALSTVLTVPDLWQQKAVNLLRAGHDVVIHAPTGAGKTYIFELLVQSDFPGKAVFTVPTRALANDKLLEWQAKGWNVGIETGDVSYNREAPIIVATLETQKRALMTGRGPSILVIDEYQMLADPARGVTYELALATAPKGTQLLLLSGSVANPQDVERWLTRCGRTVAVVRHEERPVPLDEINLDALRDRVPKTVRGRWPRYIARALAADLGPILLFAPRRKAAETLARTLASALPEANPLVLTPEQQAIAGPELIRCLKNRVAYHHSGMSYAQRAGLVEPLAKNNQLKVIVATTGLAAGINFSMRSVMVLEREYRVADAHRMLRPDELLQMFGRAGRRGMDERGTVLYLEGKPRLAEAKPLSLQRGNKVDWPSLLTVIDTAVEQGFNPLSATRQLTSNLFSQKRIPLGLEDFLHQRDSSPQTQQQGLSEQQVGGGEVIEFQNSAGIWERRRAPLLFKLEATYYLDGEHWRPGLSNPKLLSSIRIGTLCKLGNGTQRRYGIDAPLASFPQASDDDRLQLSAWLRKALRELQRSEGRKPNVPKFWPLERIERHILPLLPQLTRGGQLLELTERRNSLIARLDYARAEIHAYKDLEGKGLLNPKLRKRRIEGNQEHSEARHSGQSRSIAEYWYALGLIDRQGHPTQRGVLFSFFNHGEGLAVAAALEERTYPIEELIYDLANIRAGHRFNALAMAGRPLTAICQTRYGLKSIPGYLRRGLPEDYGEGASEILYNLEHKGKRLDQYIDDELSFGDIERARVEWDSIRAHIATAPNYDWDRWMDLKRLCQESLLATKRAFPFEKLPPLTREQRSGA
>NC_014008.1|WP_148216336.1|1691774_1692737_-|hexose-kinase
MSIPVWMEGLPRIVTVTLNSAIDQSVFVDALHPGAVHRVQRSQLQAGGKGLNVATMLALGRTPATVSGFLGEGNAGIFEAHFMRYQLVDAFIRIPGETRVGIKVLDTLHGTTDFNFSGLCPDAAAMVRLRETLGALAGPDVWFVFGGSLPEGLEVESYRELLCTLMASGARVIVDSSGVGLRTAIDVGVHVIKPNELELIEALSLEDQSPATLYGAVDRLLQRGLETVVLSMGKAGALFAQGGRRLLAQAPELEVISTVGAGDALLAGYLAACTEGRSLEDAARLATVYAWSRLTQLEPDLPDATVRDARMQAVAIQSVG
>NC_014008.1|WP_013043085.1|1690495_1691749_+|MgtC/SapB-family-protein
MDPLLQSLALSASLGALIGLIRQWGEQQEGNADLTFAGLRTFVLWALIGASSAYLNQHFVPYAFLATILVIGGHIVLRSVFASQPTSVGFTTGAAGILTVLIGGLTYWDQNTAAVVLAGLTMLTIGLKHHSHRWTRGFTQEDIRSTLQFVAVTGVVLPLVPNQGFGPMDAFNPYKLWLMVVLISGLGFVGYILMRMLGTKAGVALTGVVGGLASSTATTLAFSKESKVYPELSRGFAMAIVTACTIMVWRVLFILGLLHPPIIEHLWLPFVIFSTPGVVYALWAGLLSKEGRKTTDIPNLKNPLGLSIAIKFALLYGIITLLVKFFSSTELSQGLLILSFLSGLTDMDAIALSVTNNLKEGIVVIDLAVQAILIAAISNTLLKAGLVFSLGSKDLRKHIGIALGSMVLAGIYACIII
>NC_014008.1|WP_169305320.1|1689394_1690444_-|bile-acid:sodium-symporter
MKANSLKELFDRALNCHELSMLANLRTHGFTLWLILAVALAIWIPELAADGGLLRSEVTTLLGVMVIFFLQGLSLPTEELTLGYMPKRLHVFVLLWNFLLFPVLTVGLLRLVGSGLSEEFHLAFGLLAIMPTTVASAIAFTSLAGGATSNAIFSTIYSNVAAVWLVPAVCVAYLASSLDVVVPLFPLLAKLVCLILAPLVFGQVIHRMFPAKAALIGGRSKWVSQLIIVYIVHAAFANGVQSGVLQTVSVGDLWRIGCLCFALLVLVSTLVWGSSSVIRLRRPERIAAFFCASQKSLATGLPLATSILAATGGVLESSLLILPLMIYHPLQLMCAGVLCGWLNRGRAKE
>NC_014008.1|WP_013043083.1|1687593_1689420_+|SLC13-family-permease
MSGEMLFVFGLLAVVAVAMASNRFRFDVIALLVVCALSLSGILSVEQALSGFGNTVVILVAALLVIGEMLDRTGIARTVGDLIARKAGKHEVRILISLMLASAILGGFMSSTAIVAIFIPIVLRIAQETGVSKSKLLIPMSYAALISGMLTLIATPTNLVVNGELKQAGYDGFQFFSFTPLGLCILIAACAYFVLLGRHLLPKRSSPNTLVTSKRSAVEMFRAYNTEEKGLSYRLTPGSEFVGRPIRDSGLAAAYGLRVLSVLRQRKEKTSSVLFGDASVELRQEDQITLLGKPEAHKQLQAHPGVSEASLSQSQRNRMQWELGTSAVLIHPESSLLNKTLTEVEFQNRYNAQVIGMRRNGEVLPDFKHAKLQASDSLLVAGSWESLDQLRRLNHEFIVLEEAKEQTEKVPAYRKAPIALTILAMLVAVSVLDLLPLTITVLLAALAAVFTRCMTMEDAYRSIHWNSIVLIAGLLPMADALQVTGGTEFIVDGLMGLLGSAPYSLMFTALFFLTAGIGLFLSNTASAVLIAPIAITTAQIQEVSPIPYAIAVMIAASAAYSTPVSTPVVTLVMEPGAYKFGDYVKVGVPLLVITWLVTLLVTPWLFPY
>NC_014008.1|WP_013043082.1|1685139_1687578_+|RNB-domain-containing-ribonuclease
MDLRDTLLKLLRAPDYVPLRQEEIVAVLRLSPDKAKKATKLIAQLLDSGEVVRIKRDRLVMPKDADLVSGKILFRQSGSAILIADSDAGKKGAVGFPVSAEDTATAFHGDQVLARILRRPKRNFRRGRGRYGRQEKEPEEKPNVRVIRIQKRARETVVGNLCKGRHTWYVIPDDPRIIQDFIVPDPANCGIKPRPKEGDKVVVKILEWQQRHLNPEGEIIQLLGKTHEPDAEFKGILFKYELDPQFPAEVEQQTKDIPDEVQPEDRAGRMDCRDLFTFTIDPDDAKDFDDALSVEELEDDMLRVGIHIADVSGYVKPNTPLDKEAQKRGNSTYLVGTVIPMLPHALSNGLCSLVEAQDRLTKSVFITYSPNAGVQRVDYARTVIRSNKRLTYAQAYAFMETDDLDEVRKTPLPPKHQTGSTGRDLSEVSDGEMETLQRYIRKLWTIAEQLRKKRFRNGSLDLEMTEIKIYVDEQGYADRIEKQSHDESHQLIEEFMLAANEAVARVMKRNRFPCIYRVHDEPEDEKLQELRETMSTYGVKCGNLNKAQEMSRLLKQLKDHPQGYTLKTHVLRSLKQAQYRASPDGHYGLAKQDYTHFTSPIRRYSDLIVHRVFDAYLHKIGAESAPDKPDAKYSLEKLESISDHLCITERNSIDAERDSVKTKLLEFYERQLKKDIKQPFEAVITDIKNHGLYIEITDSMAFGMVHISTLDDDFYHPSTDGKKLTGRKSGKTYEVADTIEVVVERVDRFKRQIDFRIVSKQDARYDKRSRNAKSDRKSGKPKTAKSAKALADLRKQRRSDRLKKVRNRNRKR
>NC_014008.1|WP_013043081.1|1684768_1684957_+|hypothetical-protein
MAEDIQTHEACPTDGSCTTCSACSSGLCPGTLFAGAILIGWLVFLGVSKLTGKKKSPPPQDE
>NC_014008.1|WP_013043080.1|1683595_1684675_+|hypothetical-protein
MKPLALALTTGLLLSVGTASALELNEHFTIEGFVDLYFQHQDRDGDPVFNSPDTDERVASDSDYGLSQIELSFQANYNAWSAQLDIDYEEANSSDGSQTGEVEQLFASYQFEYGGALTLGRFGSMLGFEDFEPTGLYQYSFAYELMGLDFTLLPDYGQGIKYTYLGDQHFFGVALLDSISNQNEGSLEDSWGIELGAAYYTAHGINFFLGGAWEQNSTTNSRNPDSNQWLINGYMTAEIGIWLFAAELSYGSSRGEFIGASDVIALGPDYYGLNGLLMANYAYTRSTSVTGRFSYAHAEERENPLQNLSWDAYKWTLAHNWDVIEYCTLVTELSYTQLERESGLSAQEVLGAVKLLLHF
>NC_014008.1|WP_013043079.1|1681730_1683581_+|type-IIA-DNA-topoisomerase-subunit-B
MSANYTEDSIKSLDWKEHIRLRPGMYIGKLGDGSSQDDGIYILLKEVIDNSIDEFVMGHGKIIEVNIDGTHVSVRDYGRGIPLGKLKDCASKINTGAKYDSEAFKKSVGLNGVGIKAVNALSKEFEIQAYREGKTRCVAFAQGEVTTEDKRDKAADADNGTALRFDPDPDIFGKCRFREDYVEDMLWNYAYLNSGLTIVYNGKKFKSDKGLHDLLENKLDGDPLYPIIHLKDKDVEIAFTHASGYGEDYYSFVNGQHTTMGGTHLAAFREALAKTVKDFYKKDFDAVDIRTSICAAVSVKVEEPVFESQTKTKLGSLEMGPKGPTVRTFMNNFIKQALDNYLHRSPETAKELLSKIQESERNRKELKGIQKLARERAKKAKIHNKKLRDCRIHLDTKKEGRLDSTLFITEGDSASGSITKARDVNTQAVFSLKGKPLNSFGLTKKVVYENEEFNLLQDALNIEDGLDGLRYNNVVIATDADVDGMHIRLLLITFFLQFFPELIRQGHLHILQTPLFRVRNKKVTRYCYSDEERLAAIEECKPKPEITRFKGLGEISPDEFSNFIGKNIRLDPVIIPKGMTTKDLLTFYMGKNTPERQEFIIENLRIEKDAAEPVSA
>NC_014008.1|WP_013043089.1|1696012_1696399_+|VOC-family-protein
MITFDHTRIRVSNLDKSVDWYCQTCGFEVLKRTDKSPSGNQLVHLQLPGSSHLLELTYSPDYTVKVPEDLVHTCIRVDNIIEYCAMIEGLSIETDLWPSNWREKFVDGKKMAFITDPDGYEVEILEHS
>NC_014008.1|WP_013043090.1|1696467_1697814_-|MFS-transporter
MSQHLEQIAARNVRAFIIFRMFFSARFYYPVFALIFLDFGLTLEQFSILNAIWALTIVLCEVPSGALADTIGRRNLLITTGICMVLEMGVLLVAPIGGGTWLFVFFLLNRLISGFAEAAASGSDEALTYDSLKAAGQESRWARVLERAHRDTSFAFFFAMMTGAAVYDPDLANWVCGFFGFETSFVRTDMVKIPIFLTFLSGLVVTAMAFRMHEAVEHAHASVRATLAASWKNTLTAGQWIWRSAFPFGVILGVMALDSVIRQFLTLASEYWKVIDLPIATYGLIGSAMSVVGMVVPRYARKMVEKNTPLYNFEFLCLLVFAGAWGLGLAVPYWGIVPAVLLYAAMHFMYFFVSTYLNREAASEQRATILSFKGLSTNFAYGMVSVLYALLVAQLRLRSEGEEVDLNDSVFIESLQWFPWYFAACIALMLIIFRVRFKAKDLEQSGES
>NC_014008.1|WP_013043091.1|1697813_1698815_-|2-hydroxyacid-dehydrogenase
MIVSMFSSKPYDERYFAEENQRESGHDIIYQEAKLTAQTAPLAVGSRAVCAFVNDHLDRAVLEQLKAGGTEYIAMRCAGFNNVDLQAADELGLKVVRVPAYSPHAVAEHTLALLLTLNRRIHRAYNRVREGNFSLNGLVGFDLYGLTVGIVGTGKIGQIVAQLFKGLGCKLVCYDVFENDVMKNLGAEYVSLDELFACSDVITLHCPLLEATHHLINAEAIQKMKSGVTLLNTSRGGLIDTTAVIEGLKSGQIGNLGIDVYEEEDNLFFEDQSGEVMQDDVFARLLTFPNVLITGHQAFFTDTALTQIARVTLQNLTDLEIHGLSENEIRVQT
>NC_014008.1|WP_013043092.1|1699012_1702501_+|hypothetical-protein
MSNLIKITLFFLTYCYCEAYENNVANNYSFEDDTDGNSIADHVQFRSQAPPNLLLDSTQNAHARTGSRCVEFTPQSNNQDSYITSNFNVASSSRESFPCAERDLIGSSIYVKASENASGSNVKLDVLFFNASTGAAIADGNTPYQTSVTNLSTGWQRISVVEVAPPTANFAALRLTVGGLSDGTVYADDWEIYLMPDEEFPETGNLVANNSDLSLMGTGGNNVFDYFQNNSATGHEITLENDRAKFKHGSTTETELYLNSNREENGQKSENAFAECKPGEIYEASATIEIQDGSYEGAGVKMMLYFYRKNSSGSLVYDSSIESDRVTTTGNSKIKVYVRGETPVSAEYVSASVKSKAKQKNSIDSVVYADDIVLKQLHPALYENLDFEEAYTNNGHERAAYFKARYAENKKLALLEQGIGESYSGSQSAKIIYSDGIDYSDSIYYHAGYNDAGTAKDFKLVTPGEEHRLTVFARVTAPQNVNALAEAYIMYYKDDDSWLSNSKIEPVSSQDWTRIIIDSLAPQNAAKVTFAIRSKNFGTDCQAWFDDLWLENTNYVLNPGFSQNAPLSAYRYYLNPYAESGDENDAVFIADYLAGSEIKSTATFNFNEVSNKNLQLEGPAFVNAAEIVMGSVPVYPGETYQLSASGLTTLSGDELEIEMLFHTAYEQSGTLTVSGSAAASINTTSSNFVQLTTDEIVIPFGCDGVSYRVNYNGDGIAYVTNIELKKIDTPRHIDLQNVNALSNNTVTRSNLYTWFTQTSGVSDKFDNFIRFESFNNEPVDPEKIYWGDGYAGGANDKPLIRTTANAIMGYINVLHHILDEHEGAFPDPNPPTNQDENSPKYDYEEALKYHEWVVGGIRWLLDQGHPTADFILAPHESADLSNSSGKFYAWEDLNSTDKSRAAFYPTGFAGMALGEAYLYFHRIKDLPIGTTSGEQDIKVACLNASDDIRKFFKALHEDGDNLDLNCGNANFNLFAVWALSLNAKINHVNNPTDPSVAEALELCEYLVRKSMTGQLETGYMQDDHNQHIGYHGIITQGLVLYKKVLDEVTNVDWTSNYSDVVDHSIHRSLNHIILSMEANSEAGNFLSHPVRSFDSLGQYDYSYSNHASSAVLHAFDLYGTDKANMEHLADYAVQFTTDNTVSYNSLQGHFFYAFTCAMRYYE
>NC_014008.1|WP_013043093.1|1703143_1705042_+|amidohydrolase
MKTLLRLALSYCSLTVLFGSPTRLRADTADRIYTNGVILTMDDTKPKAEAVAVKNGKILAVGSATEVLKTRDRATEIHDLSGKALLPGFVDSHGHMMGGGIQALSANLLAPPDGDVRDIASLQATLRTWMAENQQAIDQIQLVIGFGYDNAQLAELRHPNRDDLDAVSSDIPIILVHQSGHIVAVNSKALEIGGISATTLDPQGGVIRRDSDGIEPNGVLEETAAFPLLIKLLARVGPEGSEAFVRAGAEMWARYGYTTAQDGRSMPGGVKTLKAVAQAGGLPIDVISYPDVLVGRDLIKREVSSEYVNRFRVAGAKLTIDGSPQGFTAWRDRPYYDPVGNYPPGYVGYPAATEEQVANAIDWAYAHDIQIITHSNGEAASDQLIAYIHAAAQKHGKQDRRPVLIHGQFLREDQVDALKRLEIFPSLFPMHTYYWGDWHREQTVGPVLSNYISPTGWCVQRGMKFGTHHDAPVALPNSMRVLDATVTRRSRSGDILGPDQRVDVLTALKAMTLWPAWQHFEEASKGSIEVGKLADFVILDQDPTAINPEDLDQIKVLQTIKEGVSVYQHTHSTERRVSLQHGDQPQIAFNRALGSINRHLGSSSAQAGGLCSDCLCSSVSYLTDLIGRGESQ
>NC_014008.1|WP_041745726.1|1705213_1706455_+|pyrophosphate--fructose-6-phosphate-1-phosphotransferase
MAETQPVKKVAILTAGGLAPCLSSAIGGLIERYTELHPDIEIICYRGGYKGLLQGDSIAVDAEMRATAPTLHKHGGSPIGNSRVKLTNVKDCVKRGLVEEGEDPLKVAAEQLTKDGVDVLHTIGGDDTNTTAADLAAYLAENDYALTVVGLPKTIDNDVFPIAQSLGAWTAAEEGAKYFENVVAEHNANPRMLIIHEVMGRNCGWLTAATAKAYRDRLDSLDWADGLGLTAMRKDVHAVFIPEMELDIQAEAARLKAVMDEHDNVNIFISEGAGVETIVKEMEAAGEDVPRDAFGHIKLDAVNPGKWFGEQFSKMLSAEKVLVQKSGYFARAAPANPDDLRLIKSCTDLAVDCAIARDSGVIGHDEDNRGILRAIEFPRIAGGKPFDIESPWFGELLESIGQSKGKNIAKAGH
>NC_014008.1|WP_013043095.1|1706666_1707644_+|fatty-acid-desaturase
MRTGKELILATREFAKDDPVTSWIAVITSALLLASVTAIALWVDNWLLRLPASIIAGLMWVRCFVIYHDHQHHAILDKSKLAERLMRAYGILAMTPSSIWKHSHNHHHNHNSKLRTTHIGSYPVMTAERYLRASKQEQRSYLAMRHPLMIAMGYLTIFVCGMCIIPLTQDPKKHRDAAYALSLHIALYALVASTLGLQAVLFGLFIPCLLAGAAGSYLFYAQHNFPSVSYQENNGWTYEGAALESSSYCVMGPLMNFFTGNIGYHHVHHLNAKIPFYRLPEAYAAMPELQQARTTTLHPAEIRRCLQLKVWDSAAQRMTPLPQKA
>NC_014008.1|WP_013043096.1|1707786_1709049_+|FAD-dependent-monooxygenase
MFNKKTADIMVLGAGPVGLTAAHALADKGMDFVLIDREQRTNTHSYALALHPETLELLDRLGIIEPVIKQALQLQRVAIYDYDRQQAVIDYSQLAVKYPFLAVIGQNELEAILVETLAVKGKKPLWNHRARIIEETERGAYVTVDRLMEGMTGYAVAYIDMQVDKIFEYATRYIIGADGHDSNARRTAGIRFPEVAPPKDYAVFEFTTNAQMPLEMRLIVEDEGTHMFWPLPNGRCRFSFQMPAGTATESSLTKNKHLIDTGQRKLPDLDHSHLRNLLRQHAPWFNGSIDLINWRMMVHFEHRLAECFGNNRIWLAGDAAHMSPPAGILSMNVGMHEAADLVEHLSTDDSDAVRSFRLQAYAADRLGEWKRLLDTEHHIAGTDATASWLMQHHDDIIGNIPASGESLKAILKQLHLTEAA
>NC_014008.1|WP_013043097.1|1709567_1710575_+|pseudouridine-synthase
MPNPTDLPTALEWLAKQYPDSPKKRLKEWFAQGRVTLDGEVITKPHLRLEDPGKRLSMGKPQQVPNVVFKRLPIRIHAQVNLLYIDNSLAIVNKGPGLLSVPLPGKNQPSALKILESYFKGKGASELERNRVDRATLTPLPVHRLDQYTSGLLCFAMTPQAREHLVKQVRDHSFIREYMALADGWVDPRRGTWRSWFKLDKEGMQQAVFDEPTEGATEAISHYEVIDSISWPTRDGKKQTVSRLKLRLETGLKHQLRIHSARAGCPLLGDRHYNPDFKKAAEANTGQPYGCKRQALHASHIGFVHPETGKTKRFSSKFPRDLVELEERLREKAKS
>NC_014008.1|WP_013043098.1|1710631_1711339_+|hypothetical-protein
MRQRFCILLIGTILLVLLYLCGRSIWYPVYIKLRGGRTVSEVVHEIKSTQSFNDDFSQWKSLHLLCFKEERKIEVWVSGQSGTKEIRQFDFTGYSGELGPKLRQGDGQIPEGIYEIEYLNPNSSYHLSMKISYPNEFDRLKGREDRREKLGYDIFIHGKSATVGCIPIGDDGIEELFLMVSEFGKDRVQVIISPYDMRQGRRALEITEISWENELYDIIEAASMKYAPKDSTEPH

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Crispr_ID: NC_014008_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014008_6

1890287-1890408

Orphan

Consensus_repeat	Method
AAGAAGGCACCCGCCAAAAAGGTTGCCAAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014008_6

>merge|NC_014008|6|1890287-1890408|CRISPRCasFinder
AAGAAAACAGCCGCCAAGAAGGCACCCGCCAAAAAGGTTGCCAAGAAAACCGCAACCAAGGCGAAGAAGGCGACCAAGAAGGCCGCAACCAAGAAAGCAGCCGCTAAGAAGGCACCCGCCAA

>NC_014008|6|6|1890287-1890408|CRISPRCasFinder
AAGAAAACAGCCGCCAAGAAGGCACCCGCCAA	AAAGGTTGCCAAGAAAACCGCAACCAAGGCGAAGAAGGCGACCAAGAAGGCCGCAACC
AAGAAAGCAGCCGCTAAGAAGGCACCCGCCAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014008.1\|WP_013043257.1\|1888400_1890230_+\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NC_014008.1\|WP_013043256.1\|1886572_1888270_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_014008.1\|WP_013043260.1\|1892654_1892984_+\|twin-arginine-translocase-TatA/TatE-family-subunit	unknown	unknown	gnl\|CDD\|224739
NC_014008.1\|WP_013043263.1\|1894719_1895745_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|225139
NC_014008.1\|WP_013043265.1\|1897078_1897873_+\|DUF1365-domain-containing-protein	unknown	unknown	gnl\|CDD\|377778
NC_014008.1\|WP_013043254.1\|1884967_1885342_-\|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl\|CDD\|376344
NC_014008.1\|WP_052293120.1\|1881717_1881978_-\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|198403
NC_014008.1\|WP_013043251.1\|1882029_1882425_-\|SecC-motif-containing-protein	unknown	unknown	gnl\|CDD\|380015
NC_014008.1\|WP_013043253.1\|1883472_1884831_-\|DNA-integrity-scanning-protein-DisA-nucleotide-binding-domain-protein	unknown	unknown	gnl\|CDD\|224539
NC_014008.1\|WP_013043248.1\|1878655_1879618_+\|ThuA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377643
NC_014008.1\|WP_013043267.1\|1898535_1898796_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013043259.1\|1892210_1892618_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013043261.1\|1893148_1893991_-\|inositol-monophosphatase	unknown	unknown	gnl\|CDD\|223559
NC_014008.1\|WP_013043262.1\|1894026_1894629_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NC_014008.1\|WP_013043268.1\|1898898_1900224_+\|Glu/Leu/Phe/Val-dehydrogenase	unknown	unknown	gnl\|CDD\|223411
NC_014008.1\|WP_013043264.1\|1895741_1897058_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225459
NC_014008.1\|WP_052293121.1\|1885395_1886439_-\|DUF362-domain-containing-protein	unknown	unknown	unknown
NC_014008.1\|WP_013043266.1\|1897931_1898525_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274359
NC_014008.1\|WP_013043252.1\|1882426_1883242_-\|tryptophan-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|237285
NC_014008.1\|WP_013043249.1\|1880010_1881675_+\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|223740

Protein	Function_ID	Function_description	E-value
NC_014008.1\|WP_013043257.1\|1888400_1890230_+\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	4.95846e-164
NC_014008.1\|WP_013043256.1\|1886572_1888270_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	1.28524e-05
NC_014008.1\|WP_013043260.1\|1892654_1892984_+\|twin-arginine-translocase-TatA/TatE-family-subunit	gnl\|CDD\|224739	COG1826, TatA, Sec-independent protein secretion pathway components [Intracellular trafficking and secretion].	7.13486e-17
NC_014008.1\|WP_013043254.1\|1884967_1885342_-\|NADH-quinone-oxidoreductase-subunit-A	gnl\|CDD\|376344	pfam00507, Oxidored_q4, NADH-ubiquinone/plastoquinone oxidoreductase, chain 3.	2.07859e-29
NC_014008.1\|WP_052293120.1\|1881717_1881978_-\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|198403	cd10456, GIY-YIG_UPF0213, The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1. This family contains a group of uncharacterized proteins found mainly in bacteria and several in dsDNA viruses. Although their function roles have not been recognized, these proteins show significant sequence similarities with the N-terminal GIY-YIG endonuclease domain of structure-specific endonuclease subunit SLX1, which binds another structure-specific endonuclease subunit SLX4 to form an active heterodimeric SLX1-SLX4 complex. This complex functions as a 5' flap endonuclease in yeast, and has also been identified as a Holliday junction resolvase in human.	2.6762e-31
NC_014008.1\|WP_013043251.1\|1882029_1882425_-\|SecC-motif-containing-protein	gnl\|CDD\|380015	pfam17775, UPF0225, UPF0225 domain. This entry represents an NTF2-like domain found in bacterial proteins.	3.3537e-42
NC_014008.1\|WP_013043265.1\|1897078_1897873_+\|DUF1365-domain-containing-protein	gnl\|CDD\|377778	pfam07103, DUF1365, Protein of unknown function (DUF1365). This family consists of several bacterial and plant proteins of around 250 residues in length. The function of this family is unknown.	2.90535e-75
NC_014008.1\|WP_013043248.1\|1878655_1879618_+\|ThuA-domain-containing-protein	gnl\|CDD\|377643	pfam06283, ThuA, Trehalose utilisation. This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium.	5.35611e-23
NC_014008.1\|WP_013043252.1\|1882426_1883242_-\|tryptophan-synthase-subunit-alpha	gnl\|CDD\|237285	PRK13111, trpA, tryptophan synthase subunit alpha; Provisional.	5.57343e-116
NC_014008.1\|WP_013043261.1\|1893148_1893991_-\|inositol-monophosphatase	gnl\|CDD\|223559	COG0483, SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism].	2.27902e-48
NC_014008.1\|WP_013043262.1\|1894026_1894629_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	5.32631e-07
NC_014008.1\|WP_013043268.1\|1898898_1900224_+\|Glu/Leu/Phe/Val-dehydrogenase	gnl\|CDD\|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	3.47924e-157
NC_014008.1\|WP_013043264.1\|1895741_1897058_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|225459	COG2907, COG2907, Predicted NAD/FAD-binding protein [General function prediction only].	2.45517e-118
NC_014008.1\|WP_013043253.1\|1883472_1884831_-\|DNA-integrity-scanning-protein-DisA-nucleotide-binding-domain-protein	gnl\|CDD\|224539	COG1624, COG1624, Uncharacterized conserved protein [Function unknown].	3.29829e-25
NC_014008.1\|WP_013043266.1\|1897931_1898525_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274359	TIGR02943, RNA_polymerase_sigma-24_subunit_RpoE, RNA polymerase sigma-70 factor, TIGR02943 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family.	2.99355e-38
NC_014008.1\|WP_013043263.1\|1894719_1895745_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|225139	COG2230, Cfa, Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane].	6.12567e-68
NC_014008.1\|WP_013043249.1\|1880010_1881675_+\|mechanosensitive-ion-channel	gnl\|CDD\|223740	COG0668, MscS, Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane].	1.12614e-57

>NC_014008.1|WP_013043257.1|1888400_1890230_+|DNA-primase
MPRISQRTIDTIKQQVNLVDVVSPYVQLKRAGRSFKGLSPFTQEKTPSFYVHPDRGFYKCFSTGEGGDCFTFVMKVENLEFGEAIEFLAKKFNIALEYEAGGPSREEVSLRKQIFELHELAAAWFHHEFLKGNEAAPVRRYWTEQRGFSIETAEAVKIGYAPAASNALAQLCQKRSISIAAMHQSGLFFARENERDYARFRSRFRGRLMVPIRDVQGRVVAFTARQLEQTPDDDPAREAKYVNSPETSIFHKGRILFGMDHARTHLKEGDSFLLVEGQLDAIRCWSVGLHTAVAPQGTALTEDQVHLMRRYEPASVECLMDGDAAGRKAALRYIPIAFKAGMEFKFLVLPEKADPDDLLRSEGAAGLDPIRAQAQSAIELAVRAGLPDGRAPSTQEKTAALRNIYELLQHVPSEVAREDYIQTVARILSVDSQAALKDFKQISRQRQGPQNTGPAPAPETSKDPLLTHATWELLWLLLHFPEYGLIISQALDYDWINTSSNEGQLLARIIAEYREGLIEDGTNFENLLETVEDRKLLAEIHTRNLECEFPKVQIQACLNTLYKNYLTTRKKELEHLIANNDSSSPDQLRLMREVKSIRNQLTTPLQLNF
>NC_014008.1|WP_013043256.1|1886572_1888270_+|tetratricopeptide-repeat-protein
MPKAITKSVPVFFLVILSALISGCVDPETQKANELSAATRLADEGMYDQAMDVLNELAASYPNDLEVLLTMSKVYEAQGDKTASAFILQTAQQQAPGDQSLLLRTYQAQVAAGQPSVTYLEQIAIQSPENMTPKMWEALGAARAEANQPEAALDAYMKAVATDDFTPSPASCAQIGQLFLQLENETQAERWFSTAVESEDPSALQGHFGLLEIHLRKKHWPAAEAQVEQLETQFPGAIAASKWSDVPNELARWREAQDAMRAQIEADQAAAEAKSAVEAEVAASKEAEPAKAKEAELSQTVVVDASSQENTEAAAGKTEAVEELAAMEAMANATAEEVAEPGTESTTAVSDPVSYNPDVSVLPADPDVAFNVSFDQPETAAGVEQSSNGGTTSTEAVPLAEPANTLPEISDELSLEELLSAAALAEQQRDFKLAIHYYWKAVSKNNRRAATWDLLSQAYLIDGQLINAENASLEALRLDPGNLGYMLDYLRVIQRTKTPKDFLAILETAYDRFPRSPEIALSLARAYERIEKDKLAARSFYKRFIELAPDHALRAEAEAAIERLR
>NC_014008.1|WP_052293121.1|1885395_1886439_-|DUF362-domain-containing-protein
MLASSRLDAIPTQAPIGMVFEVQASSPRHYDAAVETLLQGYEQAVGRDLVPAERKQVGLKLNTRSGKGLSTPLALVRATILALERRGYSRDSILLVDYSTHALRQAGIYPFVNEGDPRFEGCPVLPLDTERYYDPDWFYDSPLPPSMQQEPQYLSSARRGTQELVAGARERKSFLAAPLLHEVDFWINMPTMVDDPALGVDGALANATLWNVSNSQRFLANDATASAAVAEIAAIPELNERMVLHLISLERYQFIGGPNFNARYSVSEPRLWLSSDPVALDRLLYDRMNRQRMLHGFPLITPIPRQFPFAASLGLGTYDSAAIHVRQLKLGNEDDLEESAGGSQESP
>NC_014008.1|WP_013043254.1|1884967_1885342_-|NADH-quinone-oxidoreductase-subunit-A
MQIADYYPILIQICIALSIGLVIIGVSHVFGKRGTDTSIKNSPYECGMLAEGPGHARFAVKFYVTAMLFILFDIEVVFLMPWVMVFREFLAANLPILLPIFFFLGVLILGLFYELKKGAIEWEK
>NC_014008.1|WP_013043253.1|1883472_1884831_-|DNA-integrity-scanning-protein-DisA-nucleotide-binding-domain-protein
MRIDRYIARTRVIDIESRDFKGALAELLDVCEISKEKGLTKTKLLNDLLEREKQMTTYLGNGVCLPHARVPMKRNYMIAVGRCPEGLRYDGQKEYRDIRYVFLLLAAENARSYLYSLASLARVFQDKNYMARLGLAESLPDFQRELKAVFAGEGTAPTQKHNRFNNLILKEAAKIAQGSNCTSILVFGDTFGGGVELGSVFKGFNTVLIAHGTSEAASERKDIDAVLPIRSYSNQRFSQLRSAVLIGLTRGIFSSTDRLCCVGGIPQSNQFDSITVVDVEREFSTMLFHKSEMLPASVKPEVVERILAIATELAVEGREGHPVGCLFVLGNADKICEYTKPLILNPFYGYKDEDRNILNPFMDETVKELSSIDGAFIIRGDGVLVSAGSLIHAPDYTHTLPSGLGSRHAAAASITQAVDCLCVVVSGSSGQVTLFRRGEMLPLIEKALLRSR
>NC_014008.1|WP_013043252.1|1882426_1883242_-|tryptophan-synthase-subunit-alpha
MSESRIAKAFQTAKDENRAAFVAYLCAGDPDFETSVAACRAILEAGVDVLELGVPFSDPLADGLTNQLAAQRALESGATAQRVLDLVRAIREFSEVPIIFYTYYNLVFAQGSESYAKLAKAAGADGLLTLDLPPEEAGAHLAACEAEGLETVFIVAPTTPDERLETICNATTGFVYYVSREGVTGERASMSADIADRVATIKQHTDKPVVVGFGISSAEHVRTVAQAADGVVVGSAIVNCIANNLGDAAAITSALTDKMQSLTAQGALSKA
>NC_014008.1|WP_013043251.1|1882029_1882425_-|SecC-motif-containing-protein
MDCPCGRPSSYADCCEVYHSGARQPETAEQLMRSRYAAYVLGAIDYLVETTHPKARRPGLREGYLSTHQQIQWLGLEVLATSHGNAQDKTGKVEFRASYLQAGEQAVHYEKSRFKRHSGRWHYLDGVVHDR
>NC_014008.1|WP_052293120.1|1881717_1881978_-|GIY-YIG-nuclease-family-protein
MIRCADDSLYAGVATDVERRFAEHAGGGPKAAKYLRGRGPLVLVYRCELGDRSAALKEEVRIKRLSKAEKEALVQDVEHRTSNPES
>NC_014008.1|WP_013043249.1|1880010_1881675_+|mechanosensitive-ion-channel
MVKALLSCLPLLLISLSLTAQPEVLFKQAESLRSEIDSAKSAYQQVTVRAQELEGEEREIIENQLYFIASNYASEIYELADVVESLPQDNTKTTELRAYIRPVLEEIPSVFHARLSKIQTESATLRAQLADASPEQQTVLQERIAVTESHIDKLFQSLFTHNDVLRQLGITSDQSEPLIEQLQERSMLTAGRLKRASEEHKLFRSLAGEHPDSADLKQQLAATEVARSSYLASLERQVALLEKNKVDVDYYQTLLVETSGDITRGFNLKVLQRLASQTYDDLKSWFEDSFSKLIGKFFIFTLTVIIFRYLGLLARSAVVKLMERPTVKLTVLLKKTIAKGTSNLVLFIGVLIALSQIGVSLGPVLAGIGVIGFIIGFALQDTLANFAAGMMILLYRPFDVDDYIESAGVAGKVNKMSLVSTTVLTLDNQTLIIPNNKVWGDVIRNVTHQRVRRVDLTVGVAYDSDIPHVERVLQGILDNYDKTLKSPEPIISVHELGDSSVNFAFRAWVRTDDYWEAYWYLTREVKIQLDKEGIGIPFPQRDVHHYYPEKPLDE
>NC_014008.1|WP_013043248.1|1878655_1879618_+|ThuA-domain-containing-protein
MFKLPVLLVAALVLAQASASAKIKALIVDGQNNHAVWPKSTIMMKQYLEETGLFEVDIDRTRYVWKSWREKDFLPLAGTGPSENLEQPKTDPDFAPIFADYDVVISNFGWKAADWPSETQKAFEAYMAAGGGFVTVHAADNSFPKWKAYNEVIGLGGWGGRNQNDGPYVYYTDAGELKRDDSPGGAGAHGPQHEFPITIRAKEHPITKGLPEVWVSSKDECYAKLRGPAKNMTILATGRDQNPNAPTQRHEPVLMVIDYGEGRCFHTTLGHDVPAYEGVGFIVTFVRGCEWAATGKVTLPVPTDFPSADAPSKRAFVLKQ
>NC_014008.1|WP_013043259.1|1892210_1892618_+|hypothetical-protein
MKLSLTTFNLLLTAISIALLSGCGAGNPESLEDEPRRATRTGGSSLGPHLVHVDQIRRIATLSRNSADLEGDFLIATTGSNNRQTGVLKQIPKKVSNASQTADILEGKPSVNDSVREATAEESAELEKLYRDVSN
>NC_014008.1|WP_013043260.1|1892654_1892984_+|twin-arginine-translocase-TatA/TatE-family-subunit
MHTLAFLQNLSSWELILIFLVVLLFFGAKRLPELFHSFGKSMREFKRATSDIEDDIRTAMETEEAPKKPTPAPKKVEATKVVEEEDAPAAETPTAEDKPASESDTEAKA
>NC_014008.1|WP_013043261.1|1893148_1893991_-|inositol-monophosphatase
MMTTRNRQAKARYELELRHRINAGRVAVQSQVPFFNRQFGDVSSEWKEDDTRVTFADFAISERLITELRRDFSKDDFCSEESNPMDEAMALNADFAWVIDPIDGTNNYALGFVFCAISVGLLYKGEPVYGFLYDHSSGELLEGGPGQGVLRDQKKLNRSAIANDAQVMLGFHFPLSAEQAACLQPLMTQHRIRAIGSGALTAAYVATGYLTGAVDFKVKVWDIAASMAICRGAGLSFHFIRESPFPLKVFHPQADYCPYFTGTAAICEEFDQLLGSGKAH
>NC_014008.1|WP_013043262.1|1894026_1894629_-|nuclear-transport-factor-2-family-protein
MYIKALFYALSSILIGWALLGCQSHREMHTQTIPDGSYHAALERTDPELYQLPEPGSAGEAAMVEGVRRLFTNYNADDLAANLSNVYADEFYFRDAFRELSTIDELEHYLLEGLKPLNAAEFVFHRTMRSGGDFYFEWTMRLDFKKTPEGTWEESIGMTRMRFDSEGRVIFHQDYWDPTDIVYRRIPIARNLIAYVKKQL
>NC_014008.1|WP_013043263.1|1894719_1895745_+|class-I-SAM-dependent-methyltransferase
MNLALNLAEHRYLNDTLIRVGIRKLLRERLRHLSTNPRSDTSWVEELKNGPIAEHTEEANEQHYEIPAAYFQTVLGPHLKYSCGLWNHPSDTLEVSEQAMLQLSCERAQIEDGHSILELGCGWGSLSLWMAEHYPNSRITTVSNSHSQADYIRNQATQRQLDNLTVLTADINNFSTESSYDRIVSVEMFEHVRNHHALFERIRNWLKPDGLLFVHIFAHKQQSYLFEPRSDKDWMSKYFFTGGIMPSIELLPTAANGILKEQQRWRINGTHYSQTLEAWLKLQDGNEAQIQPLLQQTYGDQYRIWLQRWRIFYMACSELFAYNEGTEWCVMHYLFQNQARP
>NC_014008.1|WP_013043264.1|1895741_1897058_+|FAD-dependent-oxidoreductase
MTAQPQQKRIAVIGCGVAGLTAAWLLSRKHTVHCFEKNNYAGGHTRTLTIPTGSDAGTQVDTGFIVMNHRNYPLFSEVLNQLDVELADSSMSFSYEDRKSGYAYAGNRIRNLCPTIGHWGNLEHLKLLRDLWRFARIGYRDLTEGRLRNESLGAYCQRRGFSTAFLQNYLYPMGAAIWSSPIRQMQDFPAEPYLHFLENHGLLRLSNRPQWRYVKGGSKTYVKALLRSMNASLSLAEAPASIRRIEQGVVLHMPDGQALEYDEVVIGTHADEALNLLEDPTPTESKLLGAWSYQANDVVLHTDIRQLPADRNLWSSWNFARESEHHNTHPVSVSYHMNQLQHLSTRHDYIVTLNPTRPISSSAVINSTQLTHPLYSFESLASQEPLRELNGTRHTWFCGSYMGYGFHEDAVRSAVEIAKKFDIELSGHAQPQSKERAA
>NC_014008.1|WP_013043265.1|1897078_1897873_+|DUF1365-domain-containing-protein
MKLNSQILRGSVLHQRNHPIEHRFQYPMTFFALDLDELEQIEGNASSFGYNRNRLLSIHDKDYLHGHPTPITKQLNRLLPAQHEGERTVLVTSPRYLGYAFNPVNFHLRLRGDELICVVAEVNNTFGERHCYTLRNLRKSGAHTWKAKCPKEFHVSPFNPVKGYYVFTFRIEANTLYLGVDLYENRQCIMRTYIEGTGEAITNGNINRHALLRPFDTALNSMPRILWQAAILHFRKKLGVHKHPEAQSTHTLIRRKKQNQPYAV
>NC_014008.1|WP_013043266.1|1897931_1898525_+|sigma-70-family-RNA-polymerase-sigma-factor
MPVKPAPKVPITPPEKWVEMYSDYLFGFAMSRLRNRELAEDCVQDTFLAGIKALERFDGSRDIKFWLRGIMRNKIVDQIRKSVKEHKVNIDNEDEELLESFWFKYSGIATTNPDPWQFNPRKFYDNSEFWGVFRQCIDDVKDPARQAFVLRVLEDQSTEEVCKLMDITPNYLWVLLHRAREQLKVSLEAKWTGQKAL
>NC_014008.1|WP_013043267.1|1898535_1898796_+|hypothetical-protein
MFTCKQVSSALHREDYKDLPPLRRFFLKLHVKLCIFCGKFNRQVMESQDMCRCYKEHEDELIQNSPKMEDSKKAELERLLAEQSAK
>NC_014008.1|WP_013043268.1|1898898_1900224_+|Glu/Leu/Phe/Val-dehydrogenase
MESCNTKACQSARAIFHELEEYYDDHNIYFQTIGSVLEASDLLDVPHRLKLILTQPKNEIMVHVPVQMDDGTWELIKGYRVQHNNVLGPYKGGIRYHHEVKLDEVKTLALLMTMKCALARLPFGGAKGALKVNPRDLSEAELMRVTRRLTSALGTNIGPDYDIPAPDVGTNAQVMAWMADTYINFAESSSKVTARGVVTGKPLEFGGSAGREKATGQGVVFVLEEMLPGMGMDISQTSFSLIGYGNVGSWTARLLQQLGGSLRAVMDHTGAVYNPDGIDAEKLAEHVKSTGGVAGYPHAEAINEIEFYSTEVDLFIPAALEQMVDQEHARHMNCKVLVEAANAPTTPRAERILQDKGVEVLPAILCNAGGVTVSYFEWKQNRHSETWDEDIVDERLRTTMARSAKRVLETAARLNCNLRIASYAAAIEHIDRVYETRGVFP

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Crispr_ID: NC_014008_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014008_7

3328028-3328174

Orphan

Consensus_repeat	Method
ACGAAGTGCGGCAGCACGTAGATGGTGAACCGGAACGGTTTGCCCGAAGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014008_7

>merge|NC_014008|7|3328028-3328174|CRISPRCasFinder
ACGAAGTGCGGCAGCACGTAGATGGTGAACCGGAACGGTTTGCCCGAAGCGAAGCGTAGGATGAGTGAGCGGGTGCCCTCTGAGCAGCAAACGAACACGAAGTGCGGCAGCACGTAGATGGTAAACCGGAACGGTTTGCCCGAAGCG

>NC_014008|7|7|3328028-3328174|CRISPRCasFinder
ACGAAGTGCGGCAGCACGTAGATGGTGAACCGGAACGGTTTGCCCGAAGCG	AAGCGTAGGATGAGTGAGCGGGTGCCCTCTGAGCAGCAAACGAAC
ACGAAGTGCGGCAGCACGTAGATGGTAAACCGGAACGGTTTGCCCGAAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014008.1\|WP_013044470.1\|3313423_3314542_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|224586
NC_014008.1\|WP_013044490.1\|3338885_3339611_-\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|179510
NC_014008.1\|WP_013044482.1\|3329980_3330415_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270690
NC_014008.1\|WP_083777472.1\|3315450_3316761_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|365914
NC_014008.1\|WP_169305360.1\|3311766_3312615_-\|histone-deacetylase	unknown	unknown	gnl\|CDD\|212519
NC_014008.1\|WP_013044473.1\|3317568_3317910_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|379266
NC_014008.1\|WP_013044487.1\|3335420_3336347_+\|metal-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224033
NC_014008.1\|WP_041746265.1\|3339842_3341240_+\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|240081
NC_014008.1\|WP_013044481.1\|3328712_3329738_-\|glutamine-synthetase-beta-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|177922
NC_014008.1\|WP_013044476.1\|3323305_3323815_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|211400
NC_014008.1\|WP_013044475.1\|3322263_3323151_-\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013044486.1\|3333773_3335126_+\|metal-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|334323
NC_014008.1\|WP_013044474.1\|3318653_3321728_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223627
NC_014008.1\|WP_013044472.1\|3317207_3317576_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|379266
NC_014008.1\|WP_013044489.1\|3337815_3338880_-\|BamA/TamA-family-outer-membrane-protein	unknown	unknown	gnl\|CDD\|223801
NC_014008.1\|WP_013044477.1\|3323844_3325092_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013044485.1\|3332937_3333744_+\|metal-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224046
NC_014008.1\|WP_013044480.1\|3326029_3326776_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223498
NC_014008.1\|WP_013044483.1\|3330427_3331285_+\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|223704
NC_014008.1\|WP_013044484.1\|3331847_3332840_+\|zinc-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238498

Protein	Function_ID	Function_description	E-value
NC_014008.1\|WP_013044470.1\|3313423_3314542_-\|ATP-binding-protein	gnl\|CDD\|224586	COG1672, COG1672, Predicted ATPase (AAA+ superfamily) [General function prediction only].	6.82177e-08
NC_014008.1\|WP_013044490.1\|3338885_3339611_-\|SIS-domain-containing-protein	gnl\|CDD\|179510	PRK02947, PRK02947, sugar isomerase domain-containing protein.	1.38049e-94
NC_014008.1\|WP_013044482.1\|3329980_3330415_+\|serine/threonine-protein-kinase	gnl\|CDD\|270690	cd05120, APH_ChoK_like, Aminoglycoside 3'-phosphotransferase and Choline Kinase family. This family is composed of APH, ChoK, ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). The members of this family catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides and macrolides, leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	0.000559839
NC_014008.1\|WP_013044483.1\|3330427_3331285_+\|serine/threonine-protein-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	1.26365e-58
NC_014008.1\|WP_169305360.1\|3311766_3312615_-\|histone-deacetylase	gnl\|CDD\|212519	cd09993, HDAC_classIV, Histone deacetylase class IV also known as histone deacetylase 11. Class IV histone deacetylases (HDAC11; EC 3.5.1.98) are predicted Zn-dependent enzymes. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation). They catalyze hydrolysis of N(6)-acetyl-lysine of histones (or other proteins) to yield a deacetylated proteins. Histone deacetylases often act as members of large multi-protein complexes such as mSin3A or SMRT/N-CoR. Human HDAC11 does not associate with them but can interact with HDAC6 in vivo. It has been suggested that HDAC11 and HDAC6 may use non-histone proteins as their substrates and play a role other than to directly modulate chromatin structure. In normal tissues, expression of HDAC11 is limited to kidney, heart, brain, skeletal muscle and testis, suggesting that its function might be tissue-specific. In mammals, HDAC11 proteins are known to be involved in progression of various tumors. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients.	7.44231e-117
NC_014008.1\|WP_013044473.1\|3317568_3317910_-\|DoxX-family-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	0.000106866
NC_014008.1\|WP_013044487.1\|3335420_3336347_+\|metal-ABC-transporter-permease	gnl\|CDD\|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	6.237e-47
NC_014008.1\|WP_041746265.1\|3339842_3341240_+\|nitronate-monooxygenase	gnl\|CDD\|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	9.9052e-23
NC_014008.1\|WP_013044481.1\|3328712_3329738_-\|glutamine-synthetase-beta-grasp-domain-containing-protein	gnl\|CDD\|177922	PLN02284, PLN02284, glutamine synthetase.	2.1932e-130
NC_014008.1\|WP_013044476.1\|3323305_3323815_+\|hypothetical-protein	gnl\|CDD\|211400	cd11524, SYLF, The SYLF domain (also called DUF500), a novel lipid-binding module. The SYLF domain is named after SH3YL1, Ysc84p/Lsb4p, Lsb3p, and plant FYVE, which are proteins that contain it. It is also called DUF500 and is highly conserved from bacteria to mammals. Some members, such as SH3YL1, Ysc84p, and Lsb3p, which represent the best characterized members of the family, also contain an SH3 domain, while family members from plants and stramenopiles also contain a FYVE zinc finger domain. Other members only contain a stand-alone SYLF domain. The SYLF domain of SH3YL1 binds phosphoinositides with high affinity, while the N-terminal SYLF domains of both Ysc84p and Lsb3p have been shown to bind and bundle actin filaments, as well as bind liposomes with high affinity.	0.000789953
NC_014008.1\|WP_013044489.1\|3337815_3338880_-\|BamA/TamA-family-outer-membrane-protein	gnl\|CDD\|223801	COG0729, COG0729, Outer membrane protein [Cell envelope biogenesis, outer membrane].	1.44929e-08
NC_014008.1\|WP_013044486.1\|3333773_3335126_+\|metal-ABC-transporter-permease	gnl\|CDD\|334323	pfam00950, ABC-3, ABC 3 transport family.	1.36536e-64
NC_014008.1\|WP_013044474.1\|3318653_3321728_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223627	COG0553, HepA, Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair].	1.99409e-99
NC_014008.1\|WP_013044472.1\|3317207_3317576_+\|DoxX-family-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	0.00159017
NC_014008.1\|WP_083777472.1\|3315450_3316761_-\|peptidylprolyl-isomerase	gnl\|CDD\|365914	pfam00160, Pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyze peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.	2.42326e-44
NC_014008.1\|WP_013044485.1\|3332937_3333744_+\|metal-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	2.67897e-118
NC_014008.1\|WP_013044480.1\|3326029_3326776_+\|hypothetical-protein	gnl\|CDD\|223498	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism].	1.4046e-09
NC_014008.1\|WP_013044484.1\|3331847_3332840_+\|zinc-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238498	cd01016, TroA, Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	3.95067e-134

>NC_014008.1|WP_013044480.1|3326029_3326776_+|hypothetical-protein
MAELWKRNIEGNLYEVRSAGATLRLYRNGVHHSQYNPNRPLGGCIWDLLALPALFRPEQVRSALILGFGAGAAGRLLRELVAPDQVVGVELDEIHLSIADGFFECSEGCELVAGDAVEWVQDGAEGGRFDFILDDLYGEEGDGMPVRYAPLDLDWCRHLAELVNPGGMLVFNLIEPEKIPHLPLMTDPVLRKRFPFVHMTRMEGFENRVVTFSEQALDLAVFDTNLKAFCRQHPRCYGVSKRYLHEQL
>NC_014008.1|WP_013044477.1|3323844_3325092_+|hypothetical-protein
MTIKPWIVFAPLSLVLFLGGCATKAPELSPLPVGLPYQERQAPTDERLSLRLSYPQVASDLQRLQSTVTVQRDFVLPEGASLVVGGRVDAVEGAQTAVGWGSAGQRFQTTSYFSIVEQQIEVHLLRQGFTVVDRSKFEAVLRAQRVANGEPDTLGQSIDSSELIRAAQSAEVAADYVLQVNEFTVGPAQDEMIALRTSEAFAQLAAMNRGLADAFAEDAAVVKPGFYTVLNAKLIEVATGAICWVGSHRVDSQHVTGYTVEVPIMKRVNNAAEVNASIVARNEQLAMGMRGLKRLRAEIDSLVEERAKRELIDAAIAEYEAAVSAYRVLANQLPEGLDAAWTYDYEVLPAEVLPALPTAARMEALDQGLATQADLDAEAQRRLSAEVRRFRELVTAHVTDLAALVAGELIETVPN
>NC_014008.1|WP_013044476.1|3323305_3323815_+|hypothetical-protein
MSQVGCRSLSTEAQNEIVVMVDESLERFYQQDPELKTELTESLGYLLVDKKVVKIPGIGWGGGKGVVVANTDGARNFVKVSRLELGAGWGARSYKVLLLIDDPELLERMQEGTWVYGLGAEASAGTAAVEGTADQVKPDKEYTVHVLSDGGASATFTLRAIRVRPYSTR
>NC_014008.1|WP_013044475.1|3322263_3323151_-|hypothetical-protein
MSSLPNPRFDAVLSVVTALLLTVSSASAHMGEGAHNAAQQEYPFVLPILGQKAIDAGEELPLPFGISFAYYYVDRDIEVSTVSASINNNPVQSVDDYFAFDVGTTVHTATVRLDTWIFPFLNVYGLFGHIDNTSKINARVNLGGNEYTLQADGGFEGMTSGVGMVLAAGYQDFFMTLDGNYVYTDLGNAFNSRFEGQIYNARAGWKGKIDGHNTRIWLGATYWDTERTMSGSIPVNGGPVQKINFEVTQKPVNPSNFSIGCNYEFNEHYNIVVDLGSNFKDATIFLLSLNYRFHE
>NC_014008.1|WP_013044474.1|3318653_3321728_+|DEAD/DEAH-box-helicase
MTKPPPTFDRAFCIELAGGQVYRQAEKLFESHAVKSVEWRSPKLVGVVKGAAGLYKPMLNLRSTVFAESFCSCPIGKKGKICSHAIALCLHYEAMKREDTQAKQAVAEQQAEVEAAQQAKARSTGSGQAPRIRSIRLDSNGMPLRLLAFLPPNLEAAAARDAIVVKLDAAAGKQIQPLNQLKPGAAYAVSPGQQRAMLLVESWCGGKLAGLLQLTKARLVQLLAALQGEPVVYWVKQPNEPIAWQGEQLVGVHDFLTLSEAEQAELKQAQSTASEQGAESPEPAHSTSSGQVAEAAPKRRIELKQSLREKSKVNPRRLAESRGPSLFRSKAGDFPAVQSKDAMADYPMHRVVVDGSPNFIAVRLPSGGEAGELVAPLRNLLKSEGFLLEPSNRRWWLRDRHKTLNFLAGHWQSLKSKWRAVFTESFESKLKGIQLSELDVATKEENGQFKLEISLSEQQDETELRKAIATGKNYVDEPDGTITLLDRTSVDRLHQIERAVSGQADRPFTPTFSKRLNTADLVDVEDLLDELCEGWQPPQAWQSRSRALKQVGALEPAPVRPAFDSTLRSYQRIGVAWLWHLYRHDLGGILADEMGLGKTLQALALIECIRNQDTSLQPALVVCPASLVENWVREAARFTPGLKVLKHHGPKRAKESVVLEDFDLVVTSYGTLRQDADLMGTMDWCVVIGDEAQHIKNRRSQNARTLTSLHAKGRFLLTGTPVENSLDDLISLFSFLMPGYLDKAQGKLTQEDRAWHNKRQTERAAAYILRRTKKEVAPELPDKIEKTFFCELGAKQQRFYQDTLEKTRREIFNLEMGGANAGRLQFAAFKELLRLRQACVDPRILDETFAASESAKLAAFDEVLDECLDNGSRMLVFSSFVSALQLLAQHLKAKGHRFNYLDGQTKNRLALCDEFNEDASIPVFLISLKAGGTGLNLTGADTVVHYDPWWNPAAEAQATDRAHRIGQEKVVTSIKLIAANTVEEKVLELQAKKAELLAELFEESAAANAKVSIDDIKDLLNIER
>NC_014008.1|WP_013044473.1|3317568_3317910_-|DoxX-family-protein
MQPVPIVQLFCALSFLGYGLSCLFASHMTAEFQRYGIPQYRVLTGSLQILAAVGLLAGIWLPWLSGLAAAGLALQMACGLGLRIHIGDSWIKCLPAASYLLLCGWLATQQLLS
>NC_014008.1|WP_013044472.1|3317207_3317576_+|DoxX-family-protein
MEFVGTVLQVIIPLGILNVWLLRASRATAYRGGAAPNLKAEFAAYGMPNWSFYVVGGLKLSAATLLLLGFAWPALVRPAAGVMALLMLGAVGMHAKVKDPAVRSVPAAAMLVMSSWLVIGVS
>NC_014008.1|WP_083777472.1|3315450_3316761_-|peptidylprolyl-isomerase
MKSLLLATSLTLSLAANLHAQIYADVSVSAGASPLGTFRIQLHHDKAPRTVANFIGLATGQRNWIDPSTGQLQVDKPYYDGLIFHRLIHNFMIQGGDPLGTGSSGPGYIFQDEFDPSLTHTDYAVSMANSGANSNGSQFFITLSAPSWLDNLHSVFGEVIDDASYPNSRALIDGFKNSTNFPTTNDRPDTPITIDSIHFSGPDYASFDIHDASHQLPPVSALSMQLQHVASTGDFYLRWDAQRKHDYPLYYGADLINWQAAGNLLSMDDIPNYQVDITGIATTDTSFYRNCQVDYSAVADAPQNILAAGNSFALQPNGGTLTLNFDGLGGGTWTFVYSDGITPNDSGNITSSTQTNNSTYPVPTSGSYISSRTYARFLSLRQITVYLDGAAGPDQLTAIQPLLSFHETNSGWFDGAVLSTPANARFRGSFLYTVLE
>NC_014008.1|WP_013044470.1|3313423_3314542_-|ATP-binding-protein
MPKTPSNPFRFNQVVAKEYFCRRPESSLLTELIESGQNVALIGPRRTGKTSLALEVCRKAKRRVVHCDMMRVGSYSDVIRRLAEAALRSNQGPTIESFLQAIAHLRPTWSIDPISGGTQLTVSPSSKSTPENVIDTLRLIEKRCKATNSCLFIDEFQDLTALPKHESFIAQMRSEIQRWDDTAILFAGSDREQMKALFTDPTSPFYQSATVLTIDRLDAKTFTRYIQRRFTQSGKAIEPPIIEHVLELTGHHPNSAQKLLHFLWSKTADGATADATILEAALSLTIRAEQDEFERALDTLTHMQGRALKALAQLGGQSTTGSTFLETARIRNPTSASKALTRCVQLKILLKDQSSYRFTNPFFKIWLQRLPT
>NC_014008.1|WP_169305360.1|3311766_3312615_-|histone-deacetylase
MEKFPQAYERLKDQLRIAPPMDLTRADLERAHCPHYLDAVSFDDDRNHPHGLLSYDRNRLGLPANPQLLTRSTLETAGTVAATLHALEHGCAANLAGGTHHAFPDKGLGFCVLNDIAVAIEYLRAHGRCPDHILIVDTDAHQGNANNAYFRDDPSVFTYSIHVGKNYPAKKEPGDCDIPLPRWVESADYLDALNNSLPKIFAHTEPDLVFWIHGADCHHDDRFGQMRLTDEAMLQRDQTVLQLCKDYATRTVCVYGGGYNRQPGGTGRLHAQSIRAAADVLG
>NC_014008.1|WP_013044481.1|3328712_3329738_-|glutamine-synthetase-beta-grasp-domain-containing-protein
MAKLKLEYLWLDGYTPVANLRGKTKIEEGDPATFSLEDCPMWGFDGSSTQQADGSSSDCMLKPVALFPDSTRKNGFLVMCEVLNPDGTPHPSNARATIAEDEGLWVGLEQEYFLQQDGRPLGWPEEGYPAPQGEYYCGAGYTNVGDIARQIVEEHLDICLDAGINHEGINGEVAKGQWEFQIFGKGAHKACDQVWVARYILLRLCEKYGIDVEWHCKPVLGDWNGSGMHCNFSTDYMRETGGKEYFLKLMDKFEEYKDEHIAAYGPDNHLRLTGLHETQSIDKFSWGVADRGASIRVPHGFVKDDAYKGYLEDRRPNSQGDPYKIVSRVSKTVAEVEAEYK
>NC_014008.1|WP_013044482.1|3329980_3330415_+|serine/threonine-protein-kinase
MHEAKNTARALVRIGFDGRVHKYFRGPQAKERYDNEVRVLKFLDAKGCDFVPKIITADDADLYLVTTNAGKRVDHVSDSKRDKLFAKLEAMGVRHDDAEVRNITYDERAGQFCIIDFEFATILEPGYPPSPKMESVANRAEWKQ
>NC_014008.1|WP_013044483.1|3330427_3331285_+|serine/threonine-protein-phosphatase
MAEEAVAATERIVWSGITDVGRFRKNNEDAFLALTLDGEGVYRLGKYGEAPLSKQDYIFAVSDGMGGANAGEFASKIAVEKITRLFPRSFTTAASGIDPGFQDLLSELFDQIHAELTHLGFCYEELRGMGATLSLCWVRPGWVYFAHVGDSRIYHLPKDGGIQQVSHDHTHVGWMFREGKLTEHQARTHSGRNALQQVLGGKNQNLSPQFGAVAFEPGDRFLLCSDGLVEGLWDKGMDRLIRRPSPLHTGNPAERLVKEAVETDGRDNTTALVFEMLGSDADGEE
>NC_014008.1|WP_013044484.1|3331847_3332840_+|zinc-ABC-transporter-substrate-binding-protein
MKFENSLRCFLAAALTLFFAVSCSPTKPEELSRATEPEAAGPYSVVCTVGMITDVVRNVAGDLASVEGIIGEGVDPHLYKPTRGDVVQLNQADVVFYNGLMLEGKMADVLVRVAGSGKPVRAVTEVILENGSYLMNKDDGSGHTDPHVWMDVRGWMQAVPVVTATLSVYDPEHTEQYKANADAYLAQLKALDAYAKSSLSTIPESQRVLITAHDAFNYMGRAYGIQVRGIQGISTESEAGVRDLEELVDFIVEMNIPAVFVESSVADKNVRALVEGAKARGHAVIIGGELFSDAMGEPGTYEGTYIGMIDHNVTTITNALGGTAKGFKGE
>NC_014008.1|WP_013044485.1|3332937_3333744_+|metal-ABC-transporter-ATP-binding-protein
MNAVSKDLIPEAPAESQDARLPFSVRDLTVAYHRKPVVWDVDLAVPEGKLAAIVGPNGAGKSTLLKACLDLIPRSSGEVSIYGEPYLKQRRRVGYVPQRESVDWDFPVSALDVVAMGTYRQLGWFRRVNKRSRALAMQALERVGLADYAHRQISQLSGGQQQRTFLARALVQDADIYFMDEPFAAVDAATERAIVDLLKELQSRGKTCLVVHHDLATVPQYFDWTILLNMRVVVSGPTKEVFTEENLRKTYGGKLSLLSEAAEELART
>NC_014008.1|WP_013044486.1|3333773_3335126_+|metal-ABC-transporter-permease
MELSEVIEVLLLRDYNTRLVVLCTLLLGCACGLMGGFLLLRKRSLMGDTLSHATLPGVGIAFILAVHFGGDGKSLPLLLVGATVSGVLGVMTVLFIRNRSRIKDDAAMGIVLSVFFGLGVVILGFIQTMPQGSAAGLESFIYGKTASMVRSDFDLLVLVTAGVLVLSVLLFKEFKLLCFDESFAAAQGWPVKWLDILLLALVTAVTVAGLQAVGLILIIAFLITPAAAARFWTEKLDRMLCLSALIGGLSGWFGASLSALAPRLPAGAVIVLVAAGAFLFSLLFGAERGVCVRVLRQQGLKRSIGRQHLLRALYEILEADGGSGASVQVRPVLFRQVRGRRTWSDRELRRWLKQAYDDGLIEARERGQAIVLTEAGLDAAAKVTRNHRLWELYLIEHAEVAASRVDRDADAVEHVLGEQLVAQLETKLLQLQAADAVAMPQSPHPIQPGD
>NC_014008.1|WP_013044487.1|3335420_3336347_+|metal-ABC-transporter-permease
MEWYSIDTWIVLIGILAAMSCAVLGNFLVLRKMSMMGDAISHAVLPGLAIAFLVTHSRASLGMFIGAAIVGVLTAVFTQWISRFGNVDRGASMGIVFTTLFALGLLLIVRAADHVDLDPGCVLYGAIELTPLDVVWKPVVFGFELQVPRAALVLAGVLVLNLSFVILLFKELRIVSFDPELATTLGINANVVHYLLMTLVAVTTVAAFEAVGSIIVIAMLIVPAAAAHLLTDRLGWMIVISVLFAALTAVLGHVAALIVPGWFGFESTSSSGMMAVVAGLGFAMVFLFAPRYGIVVKRLRKLDVAEVH
>NC_014008.1|WP_013044489.1|3337815_3338880_-|BamA/TamA-family-outer-membrane-protein
MKLHQLAAPLCLAALIAGPLTAEESASTTRESPWMLVPQVSNGPKLGFSIGALAGYLHKFDEESPDSLFALTGSYSDTHSFVTGAFGRAHFDEDRQRIFGMAMFARANNEYNDFQNTGQTVSVENDLRMLFFQYQHQLRESKWYFGPTYVNTNYNPSGLNDFSQGILDGLDFSQEINAGLGIILSYDSLDNKQNPHSGQMLDVYVTGYSEAFGGDNNFFSYNGLYSYFIPLQEKWVIALNTSILATPDAPKASQATLRRFRAYTSGAVSAEYAYVAQVEARYSLTERWVAAAFGGTAAVVNGFDDMSDSENWYPMGGLGVRYILKKDAGVVIRMDYAVGKDDNQAFYLKMGQPF
>NC_014008.1|WP_013044490.1|3338885_3339611_-|SIS-domain-containing-protein
MSLAQKFFDTSNALQDKVFADNESTLQAAGKLIADSIAADGVLHTFGSGHSQILAAEIERRAGGLVPVSSINDPADGWPEQIAGYGARLFQRYAYQYAVQPKDVVLVISNSGRNASPIEVAMEARAAGLSVIAMTSLDMSKATTSRHPSGQKLYELADLVLDNGGIPGDAAIDAPGFAYKVGPTSTMTGALLLNLLSMEIIENLIRMGVTPPTYVSQNADGGAEHNEALAKKFRHRIRRPI
>NC_014008.1|WP_041746265.1|3339842_3341240_+|nitronate-monooxygenase
MIIQGGMGAAVSNWCLARAVALSGEMGVVSGTALDSVMIRRLQDGDSNGDIRRALAAFPYPEFVGPILAKWFNPEGLPEGESYKLKPLPVIDMKHEQMALLIVAGFVEIYLAKEGHDGMVGINLLEKIQLPTLPTLFGAMLAGVDSVLMGGGIPLGIPAVLDAFAGLEEAELKINVIGADKEDNFSMRLDPMDFLPRDAKPLKRPMFFPVISSDILAKTFIKKASGRVDGFVVEHHSAGGHNAPPRRGDSYGPRDECNIEKVAALGLPFWLAGNRATPEGLRDALEHGAQGVQIGTAFACSDESGITREIKDEVITRYLEGTLVVETDMQASPTGYPFKRVDLAANATPQPCQKCDLGYLRHVYKQEDGSIGYRCPAAPAEIYSKKGGDPLDCEGKRCLCNGLLATIGMPQVNKGEVFQPLLTWGEHMDFLKGVLVDGRTQYRAVDMINYVRSGVTEELLQAVGA

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Crispr_ID: NC_014008_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014008_8

3613321-3613476

Unclear

Consensus_repeat	Method
TTCGCATCGCCTCCCACTAACCTAATTCGACTCCGTCGAATGGCGGAGAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014008_8

>merge|NC_014008|8|3613321-3613476|CRISPRCasFinder
TTCGCATCGCCTCCCACTAACCTAATTCGACTCCGTCGAATGGCGGAGAGGAAGGGGGTTGGAGAGGCCTTGCCTCATCGCTGCGCGACCACCTTTGGTGTCCGTTTCGCTTCGCCTCCCACTAACCTAATTCGACTCCGTCGAATGGCGGAGAGG

>NC_014008|8|8|3613321-3613476|CRISPRCasFinder
TTCGCATCGCCTCCCACTAACCTAATTCGACTCCGTCGAATGGCGGAGAGG	AAGGGGGTTGGAGAGGCCTTGCCTCATCGCTGCGCGACCACCTTTGGTGTCCGT
TTCGCTTCGCCTCCCACTAACCTAATTCGACTCCGTCGAATGGCGGAGAGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014008.1\|WP_013044732.1\|3622369_3622594_+\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|197903
NC_014008.1\|WP_013044721.1\|3609816_3611010_+\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NC_014008.1\|WP_013044729.1\|3619382_3620549_-\|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	unknown	unknown	gnl\|CDD\|235472
NC_014008.1\|WP_013044728.1\|3617876_3619337_-\|RIP-metalloprotease-RseP	unknown	unknown	gnl\|CDD\|272878
NC_014008.1\|WP_013044724.1\|3612864_3613266_+\|diacylglycerol-kinase	unknown	unknown	gnl\|CDD\|260133
NC_014008.1\|WP_013044716.1\|3602916_3604026_-\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|224316
NC_014008.1\|WP_013044723.1\|3611899_3612649_-\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013044733.1\|3622629_3622860_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013044722.1\|3611037_3611805_+\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589
NC_014008.1\|WP_041745217.1\|3606015_3606954_+\|glutaminase-A	unknown	unknown	gnl\|CDD\|237073
NC_014008.1\|WP_013044734.1\|3622985_3623255_+\|30S-ribosomal-protein-S16	unknown	unknown	gnl\|CDD\|234588
NC_014008.1\|WP_013044720.1\|3608585_3609611_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|223135
NC_014008.1\|WP_013044726.1\|3615212_3615665_-\|tRNA-(cytidine(34)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|349967
NC_014008.1\|WP_013044725.1\|3613681_3614986_+\|3-deoxy-D-manno-octulosonic-acid-transferase	unknown	unknown	gnl\|CDD\|235589
NC_014008.1\|WP_041745218.1\|3607068_3608367_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013044730.1\|3620552_3621383_-\|phosphatidate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|366491
NC_014008.1\|WP_052293176.1\|3601897_3602611_+\|two-pore-domain-potassium-channel-family-protein	unknown	unknown	gnl\|CDD\|369572
NC_014008.1\|WP_013044717.1\|3604260_3605856_+\|mechanosensitive-ion-channel-family-protein	unknown	unknown	gnl\|CDD\|366370
NC_014008.1\|WP_052293177.1\|3621410_3622100_-\|di-trans,poly-cis-decaprenylcistransferase	unknown	unknown	gnl\|CDD\|259850
NC_014008.1\|WP_013044727.1\|3615770_3617816_-\|(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|178513

Protein	Function_ID	Function_description	E-value
NC_014008.1\|WP_013044732.1\|3622369_3622594_+\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|197903	smart00834, CxxC_CXXC_SSSS, Putative regulatory protein. CxxC_CXXC_SSSS represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.	2.07468e-05
NC_014008.1\|WP_013044721.1\|3609816_3611010_+\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NC_014008.1\|WP_013044729.1\|3619382_3620549_-\|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	gnl\|CDD\|235472	PRK05447, PRK05447, 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional.	0
NC_014008.1\|WP_013044728.1\|3617876_3619337_-\|RIP-metalloprotease-RseP	gnl\|CDD\|272878	TIGR00054, Putative_zinc_metalloprotease_slr1821, RIP metalloprotease RseP. Members of this nearly universal bacterial protein family are regulated intramembrane proteolysis (RIP) proteases. Older and synonymous gene symbols include yaeL in E. coli, mmpA in Caulobacter crescentus, etc. This family includes a region that hits the PDZ domain, found in a number of proteins targeted to the membrane by binding to a peptide ligand. The N-terminal region of this family contains a perfectly conserved motif HEXGH as found in a number of metalloproteinases, where the Glu is the active site and the His residues coordinate the metal cation. Membership in this family is determined by a match to the full length of the seed alignment; the model also detects fragments as well matches a number of members of the PEPTIDASE FAMILY S2C. The region of match appears not to overlap the active site domain. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	3.8744e-71
NC_014008.1\|WP_013044724.1\|3612864_3613266_+\|diacylglycerol-kinase	gnl\|CDD\|260133	cd14264, DAGK_IM, Integral membrane diacylglycerol kinase. This mostly bacterial family of homo-trimeric integral membrane enzymes, the products of the dgkA gene, catalyzes the ATP-dependent phosphorylation of diacylglycerol to phosphatidic acid. Escherichia coli DAGK participates in the membrane-derived oligosaccharide cycle (MDO cycle) by recycling lipids to restore phosphatidylglycerols that were used up in the biosynthesis of MDOs. DAGK also recycles diacylglycerols that are produced during the biosynthesis of lipopolysaccharides (LPS) back to phospholipids. DAGK is not the main source of phosphatidic acid in de-novo biosynthesis of glycerophospholipids. Escherichia coli DAGK has low activity as an undecaprenol kinase.	8.95248e-45
NC_014008.1\|WP_013044716.1\|3602916_3604026_-\|fatty-acid-desaturase	gnl\|CDD\|224316	COG1398, OLE1, Fatty-acid desaturase [Lipid metabolism].	2.14851e-71
NC_014008.1\|WP_013044727.1\|3615770_3617816_-\|(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	gnl\|CDD\|178513	PLN02925, PLN02925, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase.	1.55051e-137
NC_014008.1\|WP_013044722.1\|3611037_3611805_+\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	8.70622e-142
NC_014008.1\|WP_041745217.1\|3606015_3606954_+\|glutaminase-A	gnl\|CDD\|237073	PRK12356, PRK12356, glutaminase; Reviewed.	0
NC_014008.1\|WP_013044734.1\|3622985_3623255_+\|30S-ribosomal-protein-S16	gnl\|CDD\|234588	PRK00040, rpsP, 30S ribosomal protein S16; Reviewed.	7.92801e-34
NC_014008.1\|WP_013044720.1\|3608585_3609611_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	0
NC_014008.1\|WP_013044726.1\|3615212_3615665_-\|tRNA-(cytidine(34)-2'-O)-methyltransferase	gnl\|CDD\|349967	cd18094, SpoU-like_TrmL, SAM-dependent tRNA methylase related to TrmL. tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	4.9816e-85
NC_014008.1\|WP_013044725.1\|3613681_3614986_+\|3-deoxy-D-manno-octulosonic-acid-transferase	gnl\|CDD\|235589	PRK05749, PRK05749, 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed.	1.4037e-126
NC_014008.1\|WP_013044730.1\|3620552_3621383_-\|phosphatidate-cytidylyltransferase	gnl\|CDD\|366491	pfam01148, CTP_transf_1, Cytidylyltransferase family. The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast. Sec59 is a dolichol kinase EC:2.7.1.108.	8.38449e-35
NC_014008.1\|WP_052293176.1\|3601897_3602611_+\|two-pore-domain-potassium-channel-family-protein	gnl\|CDD\|369572	pfam07885, Ion_trans_2, Ion channel. This family includes the two membrane helix type ion channels found in bacteria.	1.62089e-06
NC_014008.1\|WP_013044717.1\|3604260_3605856_+\|mechanosensitive-ion-channel-family-protein	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	1.05361e-32
NC_014008.1\|WP_052293177.1\|3621410_3622100_-\|di-trans,poly-cis-decaprenylcistransferase	gnl\|CDD\|259850	cd00475, Cis_IPPS, Cis (Z)-Isoprenyl Diphosphate Synthases. Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS) catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl diphosphates. A few can also catalyze the condensation of IPP to trans-geranyl diphosphate to form the short-chain cis,trans- FPP. In prokaryotes, the cis-IPPS, undecaprenyl diphosphate synthase (UPP synthase), catalyzes the formation of the carrier lipid UPP in bacterial cell wall peptidoglycan biosynthesis. Similarly, in eukaryotes, the cis-IPPS, dehydrodolichyl diphosphate (dedol-PP) synthase catalyzes the formation of the polyisoprenoid glycosyl carrier lipid dolichyl monophosphate. cis-IPPS form homodimers and are mechanistically and structurally distinct from trans-IPPS, which lack the DDXXD motifs, yet require Mg2+ for activity.	7.07482e-120

>NC_014008.1|WP_013044724.1|3612864_3613266_+|diacylglycerol-kinase
MADNTIDPKIHKSSGLKRIVKAFCHSLDGIGSSLKHEAAFRQEAILAAIFIPLSFILRVSLVEHLILVASILLVLIVELLNSAIEAVVDDISLRNRPLAKRAKDMGSAAVLLSLLNCFICWLAVILVNWSQFF
>NC_014008.1|WP_013044723.1|3611899_3612649_-|hypothetical-protein
MKICAQLLITLAATTSAEAYSISGFSQQSIDFDSFNGSGFSATPSSGQLDSNNWAISGMSDGDSTFGGTQSSGDFARGTAAGAVSTGGIYAFDITGNTALGFQAGGSDFTPGSITLRLTNHTGTAITGLQVEYTVYVYNDQNRSNSLNFSHSSTNSSYSNEAALDLISGELADGSPSWVETARSITLDSLTLANGDVFYLRWSTNDISGAGSRDQFALDDIRLTAVPEPSTVSIFLALASLAHTQRRRR
>NC_014008.1|WP_013044722.1|3611037_3611805_+|triose-phosphate-isomerase
MSRKYLIAGNWKMNLVPAEGAALVKEIAGLVGSETAVDICVSPTFTALDAVSKEVAGSQVTVGAQNMHFEASGAYTGEISADMLKAVSVQYVILGHSERREYFGETDADVNKKTIAALAAGLKPIVCVGETLEEREAGKVTEVIKTQTEAALAGVTAAQADELVIAYEPVWAIGTGKTATPEMAEEVHAEIRCLLAGLLGEEAAEKVRILYGGSMKPENADDLLAQKNIDGGLIGGASLKAPSFASLVESAAKLS
>NC_014008.1|WP_013044721.1|3609816_3611010_+|phosphoglycerate-kinase
MATKSIKDVNLAGKRVLVRCDFNVPLKDGAVSDDSRIVAALPTIQHLADQGAKVILSSHLGRPKGEKKAEFSLSPVAEDLAAKLGKPVTFIEDCIGDEVEAEVAKLGDGDIALLENVRFYKGETDNDPEFAAALAKVADAYVNDAFGTAHRAHASTAGVTAHLSPCVCGFLIEKELAYLGEKTANAERPFTVILGGAKVSDKIKVIDALLEKADTIIIGGAMAYTFALAQGRKVGESLSEPNHVPTAQAALDKAAEKGVKFLLPVDNLAVKDLDFGAGTVGDQQIFEGEIEDGWEGVDIGPKSIELFKAEVAAAKTVLWNGPMGIFEIDACNKGTFAVAETIADSDAISIIGGGDSVKAIKMSGYSDKVTFMSTGGGASLEFLEGKELPGVSALDQN
>NC_014008.1|WP_013044720.1|3608585_3609611_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MATKIGINGFGRIGRLVFRSLVEKGLLGSEIEVVAINDLVPAENLAYLLKYDTTQGRFKGTVETKGDDTLVVNGNEIKTLAVREGPAALPWKELGVDIVIESTGLFVQDEKAKGHLEAGAKKVIISAPGKGDGVKTVVLGVNDDELTAEQDIISNASCTTNCLAPITKVVLDNFGIEEGLMTTVHSYTATQRTVDGPSPKDMKGGRTAALNIIPSTTGAAKAVGLVLPEVQGKLTGMAFRVPTPTVSVVDLTVKTTKSTSYEEICQKMKEASEGPLKGILGYTEDEVCSSDFIHDELSSIFDAGSGIALSDTFFKLVSWYDNEWGYSNRVVELVQKVSKFL
>NC_014008.1|WP_041745218.1|3607068_3608367_+|hypothetical-protein
MTADTELEELKASMLEMQKSMQAMQAKIDQLESERATQEQEIADIRASAAAPSSALPQATQQPALGPEHKGYFQIPNSSVIMKLNFKPRVDATVDTKNTGVPERFIPAKFPLKGSPDYSEGAHSNLTANGSQIRADLRVLDDPGDFHIYYQSDFYGESNKNMRYRLQHFYAEYYNFKAGFTTSVWEVADAWPDTLDYEGPNAVLFARRPLIHYKWDLSEELNLNFGVEQGDFFVDGTGAPGGANERYARLPDFALNARWENGGTRLQASTIVRDIGYRDGAGAEYNDTGWGVNLGGVVQLTDVDALRFLGVYGVGVGGMGNDTSFLDSDAGFNADGSFEALPYYSLLLAYTRNWDASWRSTFTYGYADLDPASAQDGGFFSNTTYASGNLIYQIDPRWSAGVELLYGMLEAQDGRSSGDIFRFQFGMSYSIY
>NC_014008.1|WP_041745217.1|3606015_3606954_+|glutaminase-A
MPTTVQLEQVANRAYEKFKDDTGGKNADYIKALAKVPSELFGIAIVTRAGDVITVGDVDYPFSIQSCSKVFSMCLVMQESGDETVLEKVNVEPTGEAFNSIRAIEEGDGRADNPFVNAGAIATVSLIEASSAEERWQKIIDYYSDFAGEELTVLQDIYESEAADNFRNRGIAHILYNSKNLHCEPLEATDVYTMQCSVGVTAKQLAVMGSVLANGGVNPITGERCLDAEYIPKVLAMMTMAGFYDGAGVWAWNAGLPAKTGVGGGIVAVVPGKMAIVGFAPPLDSFGNSVRAQKAIEYISDELDLNIFGTGK
>NC_014008.1|WP_013044717.1|3604260_3605856_+|mechanosensitive-ion-channel-family-protein
MIKTWFLGFFVLIASIAGLHAQVPVAEQEEATAADGQGPAMFQFHGVDLFELAQISNFPAEKRVKRLSQRMKRYANSPLIDSREISVYDDENLRVSTITVDSGDIIMGVWEADAALHNLPRQQLAQEWAKQIKDAIDQHRKDYTMENYAKAALLAAVATVVFLILWRLVHLLFRRELRYVEAKFKGKEMLKFLDGDSVVMMNENLMKVLRSGLVLAIFIIYIDVVLSFFPWTYNMSARLFELISKPFVHFGEAFVTNIPNFFALAVIGLILHLILKSTKHVFDQIAEGKVKIKGFYQDWAETTYSLLRILFVVFALVAAFPYIPGSGSPAFKGISIFMGVLVSLGSSSAVGNIFGGLMLTYMRSFQPGDFVKINGMKGTVLGRRTFSTRLKTPTNEIISIPNVAVSSNHIINYSRMTKTMGVNIGAEVTIGYDVPWRTVHELLLKSAEGVPDVLEEPAPTILQLGLGDFYVKYKLVISTKHPERKFRILSNLHQNIQDNFAKANVEIMSPHYQANREGEAITIPETRWADS
>NC_014008.1|WP_013044716.1|3602916_3604026_-|fatty-acid-desaturase
MKIKHWDTFAFVSIYHIAILALIPFAFPAFSWVALAIGIITYIIGGMAITVGYHRLYAHKAYQANPFFEWCILIGSAFAFEMSALMWSHDHRNHHNHVDTEKDPYSIKKGFWYAHVLWLFDYDRNYDKTLVTDLLKNKRVVFQDKYYLPIVLIVNFSVFFLGWAITGSAVASFFYGFLVRMALIHHCTWFINSLCHTYGSKTYARELSAVDNAVLALLTFGEGYHNYHHAFAADYRNGIRWYHFDPSKWTIWLASKLGMTTKLRTINTLTVQKSLVMKDKKMLVEHLSEEVDELAAEFKVKVEELAAVFEEKAAELTKKVRELKQASADQREKIELEIKALKASLKETWDEWVALTRQATKQFELSHAH
>NC_014008.1|WP_052293176.1|3601897_3602611_+|two-pore-domain-potassium-channel-family-protein
MSGRIKQLLEWRARLEERLGGRYTLTLVSILISLVAQPLAEQYEWLEFSINFLFILTMGFLVVSLHEDRLPRPGFILLGCATLLLIFSEIFSAVLGEWVRASSMVLLPAAVLFVAYCIALIGGSLFRQQQVTSDTLCGAIVAYLLLGIAWAGVYGILELTTVNPFDYGDWTPGGRGAALSYFSFVTLTTLGYGDILPLSEMARTLAAIEAVTGVMFGAIVVAALVANLKPRDAQSAD
>NC_014008.1|WP_013044725.1|3613681_3614986_+|3-deoxy-D-manno-octulosonic-acid-transferase
MIWLYRLLFLPGLVFALPYYLLRMWRRGGYRKDFQHRFGRFQRLPAPTENTQRVWLQAVSVGEVLAVGPLIDALQKFGDLEIVLTTTTSTGYAEARKRYADKVLCVGIFPLDFVLFSKAAWRRIQPDAIILTESELWPEHLRCARKAGKPAFLVNARMSDRSFGRYLKLRPLAAWLFGQLDHIYAASSLDQERLIALGARTETTVCAGSIKLDVAIDPLLSATERTGLRLELGFSEASFVLLGSSTWPGEEAILLEAQRQLIDQGVDCRLLLVPRHAERSPELRRLLEQQELSWYQRSTGDVVPRDLKIHLADTTGELTRLTQAADLAFVGKSVEPNKGGQTPIEAAGLGVPILMGPNMTNFKLIVAGLVRCGAADVVEDAEALKARITSLQQDAELRASMGALGRDWHRKNRGSSQRIAEGIRTDLMFERDED
>NC_014008.1|WP_013044726.1|3615212_3615665_-|tRNA-(cytidine(34)-2'-O)-methyltransferase
MLHIVLFNPEIPQNTGNIGRLCAITESRLHLIHPLGFTITDKHLKRSGMDYWHSLDVHHHDNWDAFKASPHAPKRLWLFTTKADHSYWDVEYSNDDGLLFGNEGHGAPDWLHHELEGQRLTIPHKNDSLRSLNLSTSVGIAAYEALRQLR
>NC_014008.1|WP_013044727.1|3615770_3617816_-|(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase
MTDLQHTQLHYCASRFQAQRRLSREINVGGVRVGGNNPIRIQSMTTTDTQDVDATVAQTLALAEAGCEIVRITAPNKKAAEALGEISKKVRAAKCDVPLVADIHFLPAAAMEAAKHVEKVRINPGNYADKKKFAVKEYSDADYDEELERLHEAFSPIVLRCKELGRAMRIGTNHGSLSDRIMNRYGDSPLGMVESALEFIRIAESHRYQDICLSMKASNPKVMIEAYRLAVARMNQEGMNYPLHLGVTEAGDGEDARVKSAIGIGTLLNDGLGDTIRVSLTEDPIYEVPVARDLADKAMTLWKQESSPQGPIRDAIDPFDFRRRATSTINLSARCAIGAEQLPAVIVKTTHPLRETAAIVQEVCQTQTKQKDSKLEGLIIELNDASELDYFSGLHEALHSVVECIILELNERVDLSDLEAYKWPKGMAGITLLQALPKEDSLYALSLLEFCRQKGFNFALDCTPGDLRDELGPRLQGNAQNLILCCSATPERHHPVGQVRALVDAAREFLPNTPIWIRNTSETTLAPKDYFSDRLLETSVYSGALLCDGIGDAISIETEPLLEKATALAYNILQGARARISKTEFVACPSCGRTLFDLQSVTQRIRSRTDHLKGVTIAIMGCIVNGPGEMADADFGYVGGAPGKINLYVGKECVKYNVPSNEALDRLIDLIKEHGKWVEPS
>NC_014008.1|WP_013044728.1|3617876_3619337_-|RIP-metalloprotease-RseP
MSFLSNFWYIALALFALGFSIFIHELGHFLAAKKRGLIADRFSIGFGPRLFGWKWKGTDFRLSLLPLGGYVSLPQLADMGRLEGGEKEANPLPPISYADKMIVSVMGAVFNLILAFTISLVLWWVGREEVKTTVVGHVSESIVNSEGQEVPGPAFVAGIQEGDEILTVDGRQVGSWWKYMNTVLTGVGRNDAGEPEATIEVLRDGAVHRFTINPVIASSMKTRVFGLAPETDSNSAPVVLGLIPNMPAEEAGLQFGDRILKLDDDAVISGNILSSYLTQNSDRVINVTIDRKGEEIVIPIKPKLVTDKNGVTSPKFGFYYDYEYKTEIVHYNPIQQLAGFAETMQMTLYALLHRGSNVGLDDMSGPVGIVHGLTRMAQRGWVDLIWFVALINVNLGIFNLLPIPVLDGGHMTFATISKVIGRPLPRRFMENVQMAFMMLLLGFMLYVTFFDVGRVGRDIGLISDEVPAETTNTEQPSPNDEVPTED
>NC_014008.1|WP_013044729.1|3619382_3620549_-|1-deoxy-D-xylulose-5-phosphate-reductoisomerase
MPEPKKVVLLGATGSIGTSTLQVLRAHPDRLQLVGVASRTRHQELAAICHEFGVEHAVITNERAYQAARELSHFPATTQLACGHEALTELATLADADIVLVAVVGACGLKPALAAIEAGKDIALANKELLVLGGAFVIEAARRKGIRLLPTDSEHNAIFQCIEGHPQEHLHQLILTASGGQFRETPIADLSTVTPTQATQHPNWSMGPKITVDSATMANKGLELIEAHWLFGLPAEKLQVTIHPQSIAHSFVQFVDGSILGQFSPPSMTFAIQHCLLYPDRAPGVHQTLDFAEAMQWDFRSPDFARYPCLQLAYDALRAGNCAPAIFNAANEIAVERFLNGEIRYLDIPAVIDNALQSIPSMTPSTIDDLFAIDQQTREHAHDFKPHN
>NC_014008.1|WP_013044730.1|3620552_3621383_-|phosphatidate-cytidylyltransferase
MKQRIFSFTVLWLTIIVSLTIFGIHAGVLLISAAAIFTQMELYQLFEKMGLKPMKALGLGCGAAIMIGSYYVPGLDAGNDIFLLSFLVLTITIIRMDLQAGRLRSFMPTLFGLVYIPFLLHFTLKIIKLAEVNGFETSTGLFMTVWVVAVAKSTDVGGLLVGMQIGKTPLSVISPKKTYEGALGGIVVSILVGMALVGIFSHYTPDGLNMVVAALIAIPIAVASIASDLVESAFKRQADVKDSGNIIPGIGGIFDLTDSLVLTAPLGYLLFKYSVF
>NC_014008.1|WP_052293177.1|3621410_3622100_-|di-trans,poly-cis-decaprenylcistransferase
MDGNGRWAQQRGLPRIEGHRRGADAVKRALKAAQQLGVEYLTLYAFSVENWNRPKDEIDGLMRLLDRFLVDQLKELKKRKIRLRVVGRYQELPEHIQQRLRTAEAETAMYTDHTLALALNYGARTELIDAVKAQYAAIEAGEQCIDDLNYTQFSQHLYTRDMPDPDLIIRTSGECRLSNFLLLQAAYAEIHITDIFWPDFSESDFEAAIADYHSRERRYGKTGAQVQDS
>NC_014008.1|WP_013044732.1|3622369_3622594_+|zinc-ribbon-domain-containing-protein
MPTYVYETIPAHSGQKPKRFELQQSMKDAALTTHPETGEPVQRVISGGFGTISSGKTSTDGGGGCGCDTGCGCH
>NC_014008.1|WP_013044733.1|3622629_3622860_+|hypothetical-protein
MSKIRQIDYATPRTLVSYSGKRTVRMTGRETRYKFSGVMIDGLEDEFAKIGEERNDWQKSAFPLPWSDSPDVVCPE
>NC_014008.1|WP_013044734.1|3622985_3623255_+|30S-ribosomal-protein-S16
MALKIRLQRHGATHRPFYRMVVTEASARRDGRFVEVLGTYEPQASKPENELSVKLDRVDYWKSVGAKPTDTAASLIRKARREAPAETEA

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Crispr_ID: NC_014008_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014008_9

3719513-3719648

Orphan

Consensus_repeat	Method
GAACGAAGGCCCCTGAGGACAGGGGCGGCTACATCCTTGAATGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014008_9

>merge|NC_014008|9|3719513-3719648|CRISPRCasFinder
GAACGAAGGCCCCTGAGGACAGGGGCGGCTACATCCTTGAATGAGGTTGTAGCCACGGCTGTCCCCAGCCGTGTTAGCTGTGGAGCCAGATGAACGAAGGCCCCTGAGGACAGGGGCGGCGACATCCTTGAATGAG

>NC_014008|9|9|3719513-3719648|CRISPRCasFinder
GAACGAAGGCCCCTGAGGACAGGGGCGGCTACATCCTTGAATGAG	GTTGTAGCCACGGCTGTCCCCAGCCGTGTTAGCTGTGGAGCCAGAT
GAACGAAGGCCCCTGAGGACAGGGGCGGCGACATCCTTGAATGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014008.1\|WP_013044851.1\|3729240_3730659_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013044842.1\|3716785_3717910_+\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|274787
NC_014008.1\|WP_013044845.1\|3720665_3721988_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379383
NC_014008.1\|WP_013044849.1\|3727172_3727982_+\|family-16-glycosylhydrolase	unknown	unknown	gnl\|CDD\|185687
NC_014008.1\|WP_169305369.1\|3730730_3731567_+\|DUF1080-domain-containing-protein	unknown	unknown	gnl\|CDD\|368908
NC_014008.1\|WP_169305368.1\|3726237_3726840_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_014008.1\|WP_013044844.1\|3719689_3720568_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_014008.1\|WP_013044836.1\|3708985_3709408_-\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013044853.1\|3731612_3734504_-\|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl\|CDD\|293770
NC_014008.1\|WP_013044850.1\|3728465_3729218_+\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013044843.1\|3717914_3719243_+\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NC_014008.1\|WP_041745233.1\|3706179_3706557_-\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013044847.1\|3724289_3726248_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_014008.1\|WP_169305367.1\|3710168_3714851_+\|lamin-tail-domain-containing-protein	unknown	unknown	gnl\|CDD\|379107
NC_014008.1\|WP_013044840.1\|3715206_3716073_+\|polyphosphate-polymerase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143622
NC_014008.1\|WP_013044841.1\|3716097_3716781_+\|DUF4956-domain-containing-protein	unknown	unknown	gnl\|CDD\|379819
NC_014008.1\|WP_013044833.1\|3707754_3708108_-\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013044846.1\|3721995_3724257_+\|carbohydrate-binding-protein	unknown	unknown	gnl\|CDD\|271150
NC_014008.1\|WP_013044831.1\|3706594_3707371_-\|hypothetical-protein	unknown	unknown	unknown
NC_014008.1\|WP_013044834.1\|3708191_3708605_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014008.1\|WP_013044853.1\|3731612_3734504_-\|sulfatase-like-hydrolase/transferase	gnl\|CDD\|293770	cd16151, sulfatase_like, uncharacterized sulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	2.42423e-176
NC_014008.1\|WP_013044842.1\|3716785_3717910_+\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|274787	TIGR03794, conserved_hypothetical_protein, NHLM bacteriocin system secretion protein. Members of this protein family are homologs of the HlyD membrane fusion protein of type I secretion systems. Their occurrence in prokaryotic genomes is associated with the occurrence of a novel class of microcin (small bacteriocins) with a leader peptide region related to nitrile hydratase. We designate the class of bacteriocin as Nitrile Hydratase Leader Microcin, or NHLM. This family, therefore, is designated as NHLM bacteriocin system secretion protein. Some but not all NHLM-class putative microcins belong to the TOMM (thiazole/oxazole modified microcin) class as assessed by the presence of the scaffolding protein and/or cyclodehydratase in the same gene clusters. [Transport and binding proteins, Amino acids, peptides and amines, Cellular processes, Biosynthesis of natural products].	4.50988e-13
NC_014008.1\|WP_013044845.1\|3720665_3721988_+\|hypothetical-protein	gnl\|CDD\|379383	pfam13810, DUF4185, Domain of unknown function (DUF4185).	0.0022595
NC_014008.1\|WP_013044849.1\|3727172_3727982_+\|family-16-glycosylhydrolase	gnl\|CDD\|185687	cd02178, GH16_beta_agarase, Beta-agarase, member of glycosyl hydrolase family 16. Beta-agarase is a glycosyl hydrolase family 16 (GH16) member that hydrolyzes the internal beta-1,4-linkage of agarose, a hydrophilic polysaccharide found in the cell wall of Rhodophyceaea, marine red algae. Agarose is a linear chain of galactose units linked by alternating L-alpha-1,3- and D-beta-1,4-linkages that are additionally modified by a 3,6-anhydro-bridge. Agarose forms thermo-reversible gels that are widely used in the food industry or as a laboratory medium. While beta-agarases are also found in two other families derived from the sequence-based classification of glycosyl hydrolases (GH50, and GH86) the GH16 members are most abundant. This domain adopts a curved beta-sandwich conformation, with a tunnel-shaped active site cavity, referred to as a jellyroll fold.	5.4494e-29
NC_014008.1\|WP_169305368.1\|3726237_3726840_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	7.37745e-19
NC_014008.1\|WP_013044844.1\|3719689_3720568_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.64701e-27
NC_014008.1\|WP_013044843.1\|3717914_3719243_+\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	7.32337e-10
NC_014008.1\|WP_169305369.1\|3730730_3731567_+\|DUF1080-domain-containing-protein	gnl\|CDD\|368908	pfam06439, DUF1080, Domain of Unknown Function (DUF1080). This family has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16. However, the structure surrounding the active site differs from that of the endo-1,3-1,4-beta glucanase.	8.45663e-28
NC_014008.1\|WP_013044847.1\|3724289_3726248_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.92036e-64
NC_014008.1\|WP_169305367.1\|3710168_3714851_+\|lamin-tail-domain-containing-protein	gnl\|CDD\|379107	pfam13290, CHB_HEX_C_1, Chitobiase/beta-hexosaminidase C-terminal domain.	2.74568e-20
NC_014008.1\|WP_013044840.1\|3715206_3716073_+\|polyphosphate-polymerase-domain-containing-protein	gnl\|CDD\|143622	cd07750, PolyPPase_VTC_like, Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins. Saccharomyces cerevisiae VTC-1, -2, -3, and -4 comprise the membrane-integral VTC complex. VTC-2, -3, and -4 contain polyP polymerase domains. For S. cerevisiae VTC4 it has been shown that this domain generates polyP from ATP by a phosphotransfer reaction releasing ADP. This activity is metal ion-dependent. The ATP gamma phosphate may be cleaved and then transferred to an acceptor phosphate to form polyP. PolyP is ubiquitous. In prokaryotes, it is a store of phosphate and energy. In eukaryotes, polyPs have roles in bone calcification, and osmoregulation, and in phosphate transport in the symbiosis of mycorrhizal fungi and plants. This subgroup belongs to the CYTH/triphosphate tunnel metalloenzyme (TTM)-like superfamily, whose enzymes have a unique active site located within an eight-stranded beta barrel.	4.88921e-47
NC_014008.1\|WP_013044846.1\|3721995_3724257_+\|carbohydrate-binding-protein	gnl\|CDD\|271150	cd04084, CBM6_xylanase-like, Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains. This family includes carbohydrate binding module 6 (CBM6) domains that are appended mainly to glycoside hydrolase (GH) family domains, including GH3, GH11, and GH43 domains. These CBM6s are non-catalytic carbohydrate binding domains that facilitate the strong binding of the GH catalytic modules with their dedicated, insoluble substrates. Examples of proteins having CMB6s belonging to this family are Microbispora bispora GghA, a 1,4-beta-D-glucan glucohydrolase (GH3); Clostridium thermocellum xylanase U (GH11), and Penicillium purpurogenum ABF3, a bifunctional alpha-L-arabinofuranosidase/xylobiohydrolase (GH43). GH3 comprises enzymes with activities including beta-glucosidase (hydrolyzes beta-galactosidase) and beta-xylosidase (hydrolyzes 1,4-beta-D-xylosidase). GH11 family comprises enzymes with xylanase (endo-1,4-beta-xylanase) activity which catalyze the hydrolysis of beta-1,4 bonds of xylan, the major component of hemicelluloses, to generate xylooligosaccharides and xylose. GH43 includes beta-xylosidases and beta-xylanases, using aryl-glycosides as substrates. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold.	6.51061e-19
NC_014008.1\|WP_013044841.1\|3716097_3716781_+\|DUF4956-domain-containing-protein	gnl\|CDD\|379819	pfam16316, DUF4956, Domain of unknown function (DUF4956). This family consists of uncharacterized proteins around 220 residues in length and is mainly found in various Bacteroides species. The function of this protein is unknown.	1.07705e-07

>NC_014008.1|WP_013044843.1|3717914_3719243_+|TolC-family-protein
MSCLSSHIVAVLFSTASLLSASAECGVGLEALVAAAVEQHPELELARGQVAVGQIYEAELPWWGAPELRLGYGRDTAVEDDLRASTYPDHRYAAALRFFPKNPWERSAQMRQLRSGTRLLQLDLDEQQQQIAAEVKWLYWEGSYLRLQMELQSQLLTIQEQSVARGRALLGSGQITLGQSLSSKLDYMDLSLAQEALQAEIDEIDRQLQALCGVAPETIEFATARPLTESDFDFAYEDWAVRALESRADVLRYGELQVNAKAELDTIEARRIPWLKHVQTHYRVTNSFGAEDAAGIEVAIELPFFSSDAGEKRAANQLLQSYRAQAGQGRRSVELQVASLIEAFHGLKRQWRARAPQLERMSDELETVIETMEAQGSVVNENYWDARIALIELDLRELEQQRSYQALLLRAEHVVGGVVGLPTSFEVSVETEIEEADASSGK
>NC_014008.1|WP_013044842.1|3716785_3717910_+|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MAEQERVVHLTKYRRSWWKNSGNWWPLLVFVAIAGMAYVLYHNGGKYRVMSGTAERIIEQIAPLESARVSKIHVAVGDRVRAGDLIVDLDTSLIDAEGAVLKEQIQQSLMEAKLEQLTLERQFASALQEAQQALREAELSYKVNRVEHSALLEELKRLEPLYQQQLIEAELIVAKKAREEVLREMLAIMPSHIEALEQDAQRAVEQQQSALARLQEMNEATSADHGYEEAVKLLEIRRNAFALRAQHDGVVAEIQRQPGETIEGGGSIVSLVVDGPTRIVGFLPESNVSSIAVGTPATIYPTVSLKDAGVVPAHVVQISPAVYSLPERASPIRGQVIRGRRVTFELDREVQLVPGETVSIEIQSGLFTAGLTEE
>NC_014008.1|WP_013044841.1|3716097_3716781_+|DUF4956-domain-containing-protein
MEDLQTLLGPSRLLNFSEVLVAFSVAFILSSVITSVYRYTHHGLSYSRVFVQAMLLASITSCMMIMVIGNNLARGLGILGALAIIRFRTPVRDPRDMVFLFCCLAVGIGCGARVFAVASVGAFFFSVVALYLHWAPFSAKSEFEGLLRFLLPPDSDSHDQLRAIFESHLSSATLVAVREATQGDYLEYSYQTRMLRDDSQQKLMQAIQALPDVEEPSLLMQRSTVEI
>NC_014008.1|WP_013044840.1|3715206_3716073_+|polyphosphate-polymerase-domain-containing-protein
MNQVGATVQAKAERKPVRGFKTGADMRIERHEAKYVVPYALLPEIRRHIQPYVFPDKNGRGEFPSYLVRTIQLDSRDLCLHYAKEVEQLNRFKLRIRSYGTDGKAPYFLEIKRKLGEVIVKSRSVVKAVDYGADLFTKPGRHVPFTNEREHMNYLDFLRLSKEIGAQPVTMIQYERESYMGRVEDYARVTFDTNVCYQMVSGYDFAAANSGRWRHIDTMVGLKTDFPAFILELKSKMGVPHWLLDIVRSFNLVRTGFCKYSAALRLESLSAGYEYSDASENCVPDSRW
>NC_014008.1|WP_169305367.1|3710168_3714851_+|lamin-tail-domain-containing-protein
MSAGPAWGQTIYISEVVASNEDSLLDEDGQSPDWIELYNSSDSAVDLSGWHLTDDLTVLNKWTFPATTIAAKGFLIVFASDKDRAVSGAELHTNFKLSASGESLALVRADGSTIEDSHDFGPLLEDQSYGHTFSFSDATVLLDAGAACSARIPTSSSDSAGWRELLFSGSGWVNGSTGVGYEAGSGAGYWSLLNLNVLSMRGVNSTVYIRVPFTVNAPELISALNLRMKYDDGFIAYLNGSRVAASSNAPANPVWNSQASSIHHDSQAVLYEDFDVSDHIGLLQSGANVLAIHGLNSPSTSSDLLMVPRLEAEVTDSINAAVGLLAEATPGAVNSAVSYAGIVEAVEVSPARGFYDSAISVTCTSVTAGASIYYTTDGSEPTTSSTLYSGPISVNSTTVLRTRAFRNGWSPSQPRSDSYVYVDDVVAQPKWSTQINGQDMEYGMDAAVVADTHYDANGQVVTVQDALKAIPTLSITTDPDHLYSPATGIYVNATERWERPASMELINPDGSEGFQVNFGLRIRGGWSRHSNFEKHSFRCLFKEVYGAGKLKYALFGDEGVDRFDGIDLRTAQNYNWATSNSSQNTFLRDIAARDSQGATGHPYTRSRYYHLYLNGEYWGLFMTEERPEASFAASYHGGNSEDYDVVKIRSWSESDPYQIEATDGTLDAYGRLYAAAMSGFASNADFFAVQGMDASGTPDPSFERLLDLENLIDHQLLIYYYAAKDNGVTAYQGNSKLNNLYAYYNRADPDGFKWILHDCEHSMDVVESSNLDRTGPYTHSNFQLLEYFNAQTLHEKLSVNAEYRIRFADRVYKHLKNGGALTPSPLETRFDERAAQIDRAIIANAARWGNTSRDRSTWVTAAATARAFYNGSGDRADAVIGYLDADGLIPSVEPPVLDTSEGTVAVGAQVQLSASGGSIYYTTDGTDPRAVGGAIAGTLYSGPITITQPTRVQARVRSGSGEWSALCDGTFWTEAVPLAITELMYHAPEGNGHDLIELQNISSETVSLKGYKLDDGIEFKFKNSQFPTLAPGAIMVVVDDLDAFTSKYPEVSVDLVAGEFSGDLSNGGEELDLEFRGADVIRFSYSDARNWPQAADGGGHSLIPVDAVMPHQERGALDYGANWRASTYAGGSPGAVDPVLSTDVVINEVLAHTDTELAVPFDSNDAIELYNPTNEPISLNGYYLSDDVDNPLKWAIPNGVTIAAYGYRVFDEDDFHADRVNGFGLNKAGESVVLSRVDRIVDSIRFKGQENGVSYGRYPDGSAHWMFTEATPGAENVIPTASLQIARVMYHPVAAGNDFEYVVVTNVGSSTHHLSNVTGNYRIDGDIEYDFPNGTQLAAGESLCLVSFDPAVETSLMSTFTTQYGISAANHQMHGPYSGSLSNRSGRVGIERPQDSDDPANPLDISWVVLDEVFYFDQWPWPSDADGTGFPLLRTGLSTWGVSQPGDSDADGMDDSWEYGYFGSLVDADADADGDRASNYAEYIANTDPSDGSSYFRSSQLSPSVLTWEAEPGRSYAVYWTNDLSEPFQLIASGLTGGSYTDYVNLGSANSFYYIMVSYD
>NC_014008.1|WP_013044836.1|3708985_3709408_-|hypothetical-protein
MKIEHMLAKISIELEGPQAALLLFGLLVMGFGMFMALRWMERSRDRFALLLETEASTADRVNEREWKIEYSNPMLLGVPQTCVGFKVIETDSGLYLWKHRSLTGGTRTGIAYLPNSRYDITRKYGHLDIQMKDERSNKTD
>NC_014008.1|WP_013044834.1|3708191_3708605_-|hypothetical-protein
MKPLLLSLLFVTPFLHAKENEWDTQATQLYSNASSYQFYSTFELLNELLKNEWNESIYERTMLYLGYDMLGMKKFKENHSGHSLWEPWFEEKIEFQTEILELLHPLIEKKRSGKTLSEEDLQLLSKQRERIQQKLLQ
>NC_014008.1|WP_013044833.1|3707754_3708108_-|hypothetical-protein
MEEIQQPDSFADLLPALKAIGGNLVGWLLIAALFLVALTYVWKRKEWNKGVRIGVTTCICACLLGATYFAHFWAFFGEAFTSGVDPYRWPVMLTMNVVAFLTFLVLNLKTEKLNQSR
>NC_014008.1|WP_013044831.1|3706594_3707371_-|hypothetical-protein
MTITPSRFCIFALFLLNTLNFLKATESSPFADYQNLKEIEWINFSIKPPFDMVMIAFEFGTPEARKIEIAKQLLNEREEIGFYGIIESLPDPTGIRKDWEQRRLTVDKNDRNRRFSFFHIQSPGTGDSRSSVRWLFNLDDQDELKILRMEPLGPKQRYIQRVDLEQDRANSIRSVLLSLIKAQNIEADPSSSSKLKWFYHGHKVSVGYGIGDDLICREMTIYEWENVDAELFDLIGLFNSMIKDENKRFERVATGQRR
>NC_014008.1|WP_041745233.1|3706179_3706557_-|hypothetical-protein
MKRLTLVLLLVSTLMSLGCTHISEEGKREVTVINSEDEKPVANVPLVYQYVKKPYWIVGKVKESNVYLSDDRGIAMVPESKRMTISDSSEWTLDFERMTEEQSDSVPKIYYIRNRSEAVGPSDAD
>NC_014008.1|WP_013044844.1|3719689_3720568_-|helix-turn-helix-transcriptional-regulator
MLNRSNSLRLGYLYGGEVAYQAGESLATRTLTDYEIAYIINGTVRYSANDTSYVVPAGGIIIGHKGTVETYTWSVSQETRHAYFHFSIEQLPNDWPSPDQWPRVIEKPQAVSVALFQHVIKRIYQQSDWAATSPSARDSLLLETLIDTLLEAPGPMEHGFERDRPEPVRRGLKWMRQQIDERADEAFTLSDIARAAGCSSKYLCRSFKSSMGHTPMQTNMLMRMQLSLNLLAKTNLSIAEIAQRCGYTNPLYFSRCFSKTCGRSPRQVRHDLREGKPPPSIPLPVDVIPRLQ
>NC_014008.1|WP_013044845.1|3720665_3721988_+|hypothetical-protein
MNIYIPSVRQQLSLIALGVCGVSSSFAERPWTCHGVGEATSYDCASVDQDTAPERSAQFSGVQFSGRYANYTRADTWYPCWAADGNLYSPWTDGSIGQMDFVWSGAGANARSGYAKIEGDDPMNLTISEWGTLPSPASPYQGRYPCGTLVHDGIWYYGSYALDQPNQAVKDAFGWYVMGPFMGFHWSDDYGKTWHQSPCTAESPLFDEPAREQLDLHEGKRGPFVKMGAPHFVDFGRAMEHSPDGMAYLVGHGAEFPDPKPRVANNSWVTGDAVYLARVRPAPENMNNASKYEFFSGHDSDGTAVWTQDYRAIKPILEWNNHCGIVTITYNPGLKRYFMCLTDGHIGHTSRQEYTSSILESSSLTGPWKLVAHMPQFGPQAYFLNIPSKFISEDGATMWLCSSSNYMAGDRRNDPEYVKQTTPPGCAYSLSLLEFRIIEE
>NC_014008.1|WP_013044846.1|3721995_3724257_+|carbohydrate-binding-protein
MKNWILALTSLMTTLSAAEFHVAKHGEDSNPGTAERPFLTISKGASVAMPGDIITVHEGVYREEIDPPRGGTSDSQRIVYRAAEGESVVIKGSEPVDGWEHVEGAVWKLTIDDPDAFFGAFNPFRTQIYGDWYRHEGRLNHVGQVYLNGHWLTEAVSLDAVMQPVGEVPLWYTNDRRYPKDRYGPSVDLLEFESNGQGGTGAVRVVESSERSELLVRDFSGDAYVQGQAGQWLRYDDFDFGTQATKMKLTAMTETFGGLIELRLDGPDGKLLGQCQIDSTGHMWSTGWHHFEFAITRMSGVQTICLVFKDKPKPKANEDAVIIWAQFPGLNPNEAMVEINARETVFYPRQTGINYITVSGFTLEHGSPNWAPPTAEQVGLIGTHWSKGWIIENNTIRYSSCVGITLGKYGDAMDNKAMSAEGYVGTIKRALDQGWSKANIGSHIVRNNRISYCEQAGIVGSMGVAFSEITGNEVFECHRRGLFSGAEMAGIKFHAPIDTLIANNHVYDCYRGMWLDWMTQGTRVSQNLFHGNTSEDLWMEVNHGPCVIDNNFFLSTTSINDWSQGSAFIHNLIAGHIRVSPQGRITPYHPEHSTEIAGLDRGYGGDNRFFNNIFAGADALTSYAAVELPLSTGGNLFLGEAKALDEAKDGVVLQQFDPKIQVVREDDAVFLKLTLPDTKVVKTSLITSETLGETAISKLTYKNYDASALVVSHDYWGRQRDSGMPTVGPVETSETGGTKLKLWPKGETVEPVE
>NC_014008.1|WP_013044847.1|3724289_3726248_-|serine/threonine-protein-kinase
MSSSEDRNQYDQRLAELYLEATELDENGLQSLCPNYSTLKAIDDKYKIGERIGRGGMKEVYLAFDRTTNRRVALAKLRPDRGPDDYETFIAEARLIASLSHPNIIKVHELGVMPNGHPYYTMDLKTGRTFKEYVRKHTLEESLKAFAKACDAIAYAHSKNIIHLDLKPPNLQCDKFGEILVCDWGLALNLTTLPDEPTDQLDEMDYDPVSAQGTPGFSAPEQAEHSSKLGIETDIYSLGCILYYIYTQQPLLPEKGETSGAQTHTLSKIPSSIRAIIAKATAKQADQRYSSVHAFQQDIAKYFNGHAPDAEHAHFGKLTWLFILRNRMTVMSTVTVCGLLAFGALYYSYSLAQQKANALEAKQQSSYLAGQVSNLNQQLDSSREVSTRSAKLIAETAQQLRIQSIFDNPSTAVYLSQTLINISRQYDPAESTALNADAFLSFIKLDIRKYREISALGAESSITDRFSPLAERFSDFQFGRSYRPSVNQLVTFFETASELRQGLTDESEQIISYDSACRTDHSNYHKVLESFIRYRHYGSKEISIQYQVSDEQLHLRSNIPLRLSGHVSHQRCVLRYMPFKALKLTTPHAFNLAELKELRIETLDISESPKAYLEGPLDLPQLQAIRISKAVTLPDHLAMQLQKIPDLTIRSD
>NC_014008.1|WP_169305368.1|3726237_3726840_-|sigma-70-family-RNA-polymerase-sigma-factor
MQSTLHNTSHTLLAKVHDLSDHQAWNTFVAKYQRFICHILRQSNIAPSDVDDLCQQILLKLTKSIGNYDRSRAKFRTWLAQLIRNTLFDHYRKVYAKGEHIDSEALSGSLEDEQSSQRMEQHIEQEWALFIVNTAMTRVEGHFRGDSVEVYRLTLKGLSADAIAQQKGLTVSTVYSMNKRVKAKVYQEIRKLQQELEYEF
>NC_014008.1|WP_013044849.1|3727172_3727982_+|family-16-glycosylhydrolase
MKKLTLSLITAGIVTAGSLLHASPPTSGWTMVKNVSDEFNTGTVDGAKWRKDAYATNGYIWPGSPPKNWTPGWYFVPWNVHEWGGQLRIRAKRENYNGRPYTSGIVTSKYRIKYGYMEARMQGAPGTLNTAFWAADQVNGANNYWHELDVQEGRGDDTWWADRLRVHMHRWSDWRYNSQVHPGSSEQGIALGSNANLSSNFRTYGCWWEPNKVRFYYENGSTPKMTINHNWMNQPLRVILSLGVFSAKLPEQIGQQEWMEVDWVRMWMK
>NC_014008.1|WP_013044850.1|3728465_3729218_+|hypothetical-protein
MITRVYNSSSLIGGVFFTALFGTIVFCSICCMPLAAVEPAAGSAEPPVVERTEVAEGSSQKPMDIAVALLETKIIVPPPMIDARDLEAITGIRNMGEAPFGFSYLRAVYYANGEAQSTTIYLNAHFESIQKELGNAREKEMIQDPNHDPSQIGEVFVSGDHPTEEPVVAPEDQYTIAGYPFAGDYYDAKYIKSLRPSHEFEIAPAEVYVISTESAGTHMGNSFRFKDRALLLEFLDAEAELIGQVRVAID
>NC_014008.1|WP_013044851.1|3729240_3730659_+|hypothetical-protein
MRGTLIIAVIAFAIGVLLTAWYVADEDAALAGNLQVPEALSNGAANSMERDDAVRNEAVTDRTPQVTEIGQSIRAIQASHPELYAYIVQDQESALLTALLKELSYLDPRAAARMIEQQEAGEFRDRLFYQFAETWRKSDPIASLSWLKTQAAFVNTATYRSELYETMVAVAKLNPDTAMANLDLLNNPGEQEAVIASMAEGWMAVSTDAAFEWLERLDEQGASNHLIKSAYGNIMSLYAQTKPKEAAAVIESIEDAALRWDLTAPLIDGFASDDMEGALDWVLISKHDESRAYGLMLITERGAIETERLLDVLKDDPALLDADSHQVLLSVVVGHAAREDPQMLMGRVGQFPSQLQASVIRQTVADWYQSDEAQTMEWLSRSARGEHYDIAAKQIASDMLAKDAFAALDLAQTIQSADQRFEALTAILSSSREAELTRLVDAVDFTYLSDEQHLALAGILESKQLMSPLVLP
>NC_014008.1|WP_169305369.1|3730730_3731567_+|DUF1080-domain-containing-protein
MRLIPQALVVSGTVLSLFSGCAHFSNKAQSKATESVEYTALFNGEDLSGWNPVLRVPTDPRADEVFQVEDGAIHVFKNFPQDYGVTERRNATHGMLFTEQSFSRFILRFEYKWGDILLNNYATYQYDAGVYYHISGQGVWPHGLEYQVRYDHVEDRNHTGDFWASSVQIDWTSADGEHFAHPADGGQIVPRKRGEHRALKGASVHKLDGEWNRCEVIVMGSDYAIHKLNGQVVNVGTNLTAGEGVIGLQAETAEIFYRNIEILELPESLPIDHFLAAE
>NC_014008.1|WP_013044853.1|3731612_3734504_-|sulfatase-like-hydrolase/transferase
MKNASSLIAASCITATAIQAATIWSEDFDAQSVGTTATNNINIGSTQVGGRNAVSTEIVSATSLPGFTRASGNVLKLVDAGTNSYAAMAYAANDELSISSIQSTDEYVFSVDIYFETTLARPIGEFQPRLKLNGSGGNGSTVDTAALPAGTSAGEYTISYTGTISDFLSSDFNPNSAKPFFYIDQRTASNTVFYVDNLRFETIDVPVDETQATSPIPSDGKELVPFDSRLTWGTNATPINYQVYLSTDETSVLNALPSALQGSFTNASFNPHGLAFDQTYYWRVDTVYEGGTRVTGPVWSFSTAARRTGERPNIIFIMVDDLSHLGISAYAPGASMYNYWNPSLFDVEISTPRIDSLAESGMRFDHFYTYPLCEPTRVCLFSGMNNIRNFTGHRDLSASTVTFANLLQDAGYATCLTGKWKQGGAPNADPNLDTLHRFGFDEYIAYDYNGTGNTYKNPRLVSNGSVTWYTNGEYSPDLINAYALDFIERNQNGPFFVCYPMILVHKNNGPTPDSSGTAYADYNGTDQLPEYYPDMIAYMDKMVGQVIDKLDELGIREETCIIFTADNGTEGAFVQRLADGTLYRGGKNLDNDRGLHVPLLVNQPGTVPSGQGSTHGVNNDLLQMDDIFPTLCDIAGVPIPENLRLDGRSFYPQTLGENGTPREFLFHYSSHSGSDVGAIVPDALDVYVWNHDYKLFSDGRFYDLRNDWLEESPLDINNLSSEQQLSFDWLSQLLTAREFTEASSTRLGHGSLELVVGQSVQAQATVLPATTTRNSLKWTSTNSTIASVDTSGVVTAQSIGSTTITVTNFDGLAPASFTVTVSAAAMDSVGDGIPDVWRAAHFGGDGTSIIPELSCASCDPDADGFDNETEFKLGGDPNTPDNPTELRIVSRSGERVLQFSQPLPSGYAGKRLLHSLEETSDLDSADWTPTPGFYKQPASNQLIEMPLANEQARKFYRIRGEVE

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_014008_5	5.1\|1695924\|49\|NC_014008\|CRISPRCasFinder	1695924-1695972	49	NC_014008.1	3053168-3053216	1	0.98
NC_014008_7	7.1\|3328079\|45\|NC_014008\|CRISPRCasFinder	3328079-3328123	45	NC_014008.1	3321814-3321858	2	0.956
NC_014008_7	7.1\|3328079\|45\|NC_014008\|CRISPRCasFinder	3328079-3328123	45	NC_014008.1	3326885-3326929	2	0.956
NC_014008_7	7.1\|3328079\|45\|NC_014008\|CRISPRCasFinder	3328079-3328123	45	NC_014008.1	3336543-3336587	2	0.956

1. spacer 5.1|1695924|49|NC_014008|CRISPRCasFinder matches to position: 3053168-3053216, mismatch: 1, identity: 0.98

tttaactttcacttgatccggttcgcttcgcgcccggtcatgtcgtcgc	CRISPR spacer
tttcactttcacttgatccggttcgcttcgcgcccggtcatgtcgtcgc	Protospacer
*** *********************************************

2. spacer 7.1|3328079|45|NC_014008|CRISPRCasFinder matches to position: 3321814-3321858, mismatch: 2, identity: 0.956

aagcgtaggatgagtgagcgggtgccctctgagcagcaaacgaac	CRISPR spacer
aagcgtagggtgagtgagcgggtgccctctgggcagcaaacgaac	Protospacer
*********.*********************.*************

3. spacer 7.1|3328079|45|NC_014008|CRISPRCasFinder matches to position: 3326885-3326929, mismatch: 2, identity: 0.956

aagcgtaggatgagtgagcgggtgccctctgagcagcaaacgaac	CRISPR spacer
aagcgtagggtgagtgagcgggtgccctctgggcagcaaacgaac	Protospacer
*********.*********************.*************

4. spacer 7.1|3328079|45|NC_014008|CRISPRCasFinder matches to position: 3336543-3336587, mismatch: 2, identity: 0.956

aagcgtaggatgagtgagcgggtgccctctgagcagcaaacgaac	CRISPR spacer
aagcgtagggtgagtgagcgggtgccctctgggcagcaaacgaac	Protospacer
*********.*********************.*************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1508870 : 1517630

uncultured_Caudovirales_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013042939.1\|1508870_1509869_+	serine/threonine protein kinase	A0A292FW58	Feline_leukemia_virus	1.9e-09	21.2
WP_013042940.1\|1509886_1511338_+	RNA polymerase factor sigma-54	NA	NA	NA	NA
WP_013042941.1\|1511379_1511763_-	GxxExxY protein	A0A0N7KVS7	Yellowstone_lake_phycodnavirus	3.1e-08	40.9
WP_013042942.1\|1511908_1512766_-	universal stress protein	A0A2H4J154	uncultured_Caudovirales_phage	2.7e-52	38.8
WP_013042943.1\|1512790_1514278_-	SulP family inorganic anion transporter	A0A2H4J153	uncultured_Caudovirales_phage	7.4e-175	67.4
WP_013042944.1\|1514421_1515561_-	radical SAM family heme chaperone HemW	NA	NA	NA	NA
WP_174259142.1\|1515560_1516289_-	ABC transporter ATP-binding protein	M1IB70	Acanthocystis_turfacea_Chlorella_virus	1.1e-09	23.7
WP_013042946.1\|1516504_1516693_+	DUF4250 domain-containing protein	NA	NA	NA	NA
WP_148216327.1\|1516787_1517630_-	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	7.5e-15	29.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014008

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection