CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014033	Prevotella ruminicola 23, complete sequence	7 crisprs	WYL,PD-DExK,DEDDh,cas3,PrimPol,cas2,cas9,RT	0	9	1	0

1. NC_014033

CRISPR-Cas detection and classification

Crispr_ID: NC_014033_1

• CRISPR_ID: NC_014033_1
• CRISPR_location: 82102-82201
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014033_1

Consensus_repeat	Method
TATTTGGTATTCTTCTCACTTATT	CRISPRCasFinder

spacers of NC_014033_1

>1.1|82126|52|NC_014033|CRISPRCasFinder
ATTACCTCTGAGCTTCGCTCTAAGGTACTTCCGTTCGAGAAAACTCAAATAA

CRISPR arrays and Neighbor proteins around NC_014033_1

CRISPR arrays

The CRISPR arrays of NC_014033_1

>merge|NC_014033|1|82102-82201|CRISPRCasFinder
TATTTGGTATTCTTCTCACTTATTATTACCTCTGAGCTTCGCTCTAAGGTACTTCCGTTCGAGAAAACTCAAATAATATTTGGTTTTCTTCTCACTTATT

>NC_014033|1|1|82102-82201|CRISPRCasFinder
TATTTGGTATTCTTCTCACTTATT	ATTACCTCTGAGCTTCGCTCTAAGGTACTTCCGTTCGAGAAAACTCAAATAA
TATTTGGTTTTCTTCTCACTTATT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014033.1|WP_013064196.1|93321_93882_+|ribosome-recycling-factor	unknown	unknown	gnl|CDD|178850
NC_014033.1|WP_049769044.1|72673_74635_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013065077.1|89149_91132_-|PAS-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_014033.1|WP_013064802.1|93882_94812_+|ribosome-small-subunit-dependent-GTPase-A	unknown	unknown	gnl|CDD|234631
NC_014033.1|WP_033151010.1|82254_83586_+|sodium:proton-antiporter-NhaD	unknown	unknown	gnl|CDD|215071
NC_014033.1|WP_041385474.1|98553_99519_+|SPFH-domain-containing-protein	unknown	unknown	gnl|CDD|259800
NC_014033.1|WP_177168179.1|83621_86357_-|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|223715
NC_014033.1|WP_041385473.1|94822_97267_+|S9-family-peptidase	unknown	unknown	gnl|CDD|224423
NC_014033.1|WP_013063531.1|72004_72499_-|acetyltransferase	unknown	unknown	unknown
NC_014033.1|WP_041385470.1|77645_79046_+|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013065478.1|80148_81387_-|saccharopine-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|224662
NC_014033.1|WP_013064392.1|70529_71264_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|225130
NC_014033.1|WP_177168180.1|86375_89147_-|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|223715
NC_014033.1|WP_013064721.1|69066_70365_-|phenylacetate--CoA-ligase	unknown	unknown	gnl|CDD|341239
NC_014033.1|WP_187288014.1|91133_93035_-|PAS-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_014033.1|WP_013064777.1|75548_77465_-|molecular-chaperone-DnaK	unknown	unknown	gnl|CDD|234715
NC_014033.1|WP_013065292.1|71267_71993_-|DUF2461-domain-containing-protein	unknown	unknown	gnl|CDD|378166
NC_014033.1|WP_013065715.1|97306_98386_-|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl|CDD|234664
NC_014033.1|WP_013065334.1|81443_82049_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013063920.1|79085_80108_-|recombinase-RecA	unknown	unknown	gnl|CDD|236476

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014033.1|WP_013064196.1|93321_93882_+|ribosome-recycling-factor	gnl|CDD|178850	PRK00083, frr, ribosome recycling factor; Reviewed.	2.25096e-91
NC_014033.1|WP_013065077.1|89149_91132_-|PAS-domain-containing-sensor-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.41148e-50
NC_014033.1|WP_013064802.1|93882_94812_+|ribosome-small-subunit-dependent-GTPase-A	gnl|CDD|234631	PRK00098, PRK00098, GTPase RsgA; Reviewed.	2.02164e-177
NC_014033.1|WP_033151010.1|82254_83586_+|sodium:proton-antiporter-NhaD	gnl|CDD|215071	PLN00137, PLN00137, NHAD transporter family protein; Provisional.	1.87723e-134
NC_014033.1|WP_041385474.1|98553_99519_+|SPFH-domain-containing-protein	gnl|CDD|259800	cd03402, SPFH_like_u2, Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease, and in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.	1.63987e-125
NC_014033.1|WP_177168180.1|86375_89147_-|transporter-substrate-binding-domain-containing-protein	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.25504e-49
NC_014033.1|WP_041385473.1|94822_97267_+|S9-family-peptidase	gnl|CDD|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	1.92227e-58
NC_014033.1|WP_013065478.1|80148_81387_-|saccharopine-dehydrogenase-family-protein	gnl|CDD|224662	COG1748, LYS9, Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism].	4.37932e-148
NC_014033.1|WP_013064392.1|70529_71264_+|MBL-fold-metallo-hydrolase	gnl|CDD|225130	COG2220, COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only].	9.05736e-31
NC_014033.1|WP_177168179.1|83621_86357_-|transporter-substrate-binding-domain-containing-protein	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.87427e-51
NC_014033.1|WP_013064721.1|69066_70365_-|phenylacetate--CoA-ligase	gnl|CDD|341239	cd05913, PaaK, Phenylacetate-CoA ligase (also known as PaaK). PaaK catalyzes the first step in the aromatic degradation pathway, by converting phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Phenylacetate-CoA ligase has been found in proteobacteria as well as gram positive prokaryotes. The enzyme is specifically induced after aerobic growth in a chemically defined medium containing PA or phenylalanine (Phe) as the sole carbon source. PaaKs are members of the adenylate-forming enzyme (AFE) family. However, sequence comparison reveals divergent features of PaaK with respect to the superfamily, including a novel N-terminal sequence.	0
NC_014033.1|WP_013063920.1|79085_80108_-|recombinase-RecA	gnl|CDD|236476	PRK09354, recA, recombinase A; Provisional.	0
NC_014033.1|WP_013064777.1|75548_77465_-|molecular-chaperone-DnaK	gnl|CDD|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NC_014033.1|WP_013065292.1|71267_71993_-|DUF2461-domain-containing-protein	gnl|CDD|378166	pfam09365, DUF2461, Conserved hypothetical protein (DUF2461). Members of this family are widely (though sparsely) distributed bacterial proteins, about 230 residues in length. All members have a motif RxxRDxRFxxx[DN]KxxY. The function of this protein family is unknown.	5.93125e-91
NC_014033.1|WP_013065715.1|97306_98386_-|tRNA-2-thiouridine(34)-synthase-MnmA	gnl|CDD|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	2.11578e-148
NC_014033.1|WP_187288014.1|91133_93035_-|PAS-domain-containing-sensor-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.98774e-27

Protein sequences

>NC_014033.1|WP_013065334.1|81443_82049_-|hypothetical-protein
MNNELNNEVKWSDNVVLVDADYVDTVAFNLIVNFERMIGRRIPQADIAKWLDCVALDGGVREGENDIQVILIHQKDQQQMKNFVPGNYANDLSEKAFKDHLGEFTINAYQPEEFAKTGDFFCEVLELVCAQKNIKRLMVIPNAEDASIYNKVRETLRHADDDDKRITVFSMQPQTGGNYRQEILGYSLMAALGIKADEIKD
>NC_014033.1|WP_013065478.1|80148_81387_-|saccharopine-dehydrogenase-family-protein
MAKVLMIGAGGVATVAAFKIAQNADVFTEFMIASRRKAKCDKIVEDIHKAGYKMDIKTAQVDADDVEQLKVLFNDFKPELVINLALPYQDLTIMDACLACGCNYLDTANYEPKDEAHFEYSWQWAYRERFEKAGLTAILGCGFDPGVTSIYTAYAAKHHFKEIQYLDIVDCNAGDHHKAFATNFNPEINIREITQKGLYWEDGKWVETEPLEIHKDLTYPEIGPRDSYLLHHEEIESLVINYPTIKRARFWMTFGQQYLKHLEVIQNIGMSRIDEVEYEAPLADGTGTAKVKIVPLQFLKAVLPNPQDLGENYEGQTSIGCRIRGIGNDGKEHTYYVYNNCSHRAAYEETGMQGVSYTTGVPAMIGAMMFCKGLWNTPGVHNVEEFDPDPFMEQLNKQGLPWHEIHDGDLEL
>NC_014033.1|WP_013063920.1|79085_80108_-|recombinase-RecA
MAKEKDEALSPQQEKLKALQAAMSKIEKDYGKGSIMRMGDEQIDNVEVIPTGSIGLNAALGVGGYPKGRIIEIYGPESSGKTTLAIHAIAECQKNGGIAAFIDAEHAFDRFYAAHLGVDVENLYISQPDNGEQALEIADQLIRSSAIDIIVIDSVAALTPKKEIEGDMGDSAVGLQARLMSQALRKLTSTISKTNTTCIFINQLREKIGVMFGNPETTTGGNALKFYASVRLDIRKVTAIKDGDNIIGNQVRVKVIKNKVAPPFRKAEFEITFGEGISKIGEIVDLGVEYEIIKKSGSWFSYGDSKLAQGRDAVKALLKDNPELCEELEAKIMEAIADKK
>NC_014033.1|WP_041385470.1|77645_79046_+|hypothetical-protein
MMKKTFLTACMAFAFMAASAQTNSYIVKTKGATKSAQNHMADEIAEAMEEDEESAKDFISQNFRFHSLCDWEEGMKFMVMPDKYDLVVKTFTETATGKNVSNLTLKYKIMIYKGHSESKDGHALINFQCQDDGKSYYYEIDYGTFEDYCFQKTGVPTLAYLGDVDIAKEKLMDKMLYTKTKLYRMDTEYDGEGYQEVLVDQDMVVKVVAVGVGSRNFPVKIVVEDKDGNQFYQNVTMSRTNCGLRDDELAGEDARFLFNNSFELQDDIMSISSRNYKLFIGKVVHTKIPVKMLNEVTSKQQAIPRLAEYKIESITPHKSDNMATVKLKNTTLGTYFYSECFLDQYQSEAHPDQFFGLIFAPGPGKKVVTSEASRAMIRAGHVGVGMSEDEVQMAAGEPDKVEPGQGGQYFWVFNRSNDKLLYVEFDGTGVVKKTSVKDMNEGTGKKKKKPQPVKGWMGGKADPTAE
>NC_014033.1|WP_013064777.1|75548_77465_-|molecular-chaperone-DnaK
MGKIIGIDLGTTNSCVAVFEGNEPVVIANSEGKRTTPSVVGFVDNGERKIGDPAKRQAITNPKNTVYSIKRFMGENWQQTEKEIGRVPYTVVNEGGYPRVDINGRKYTPQEISAMVLQKMKKTAEDYLGQEVTEAVITVPAYFSDSQRQATKEAGQIAGLDVKRIVNEPTAAALAYGVDKANKDMKIAVFDLGGGTFDISILEFGGGVFEVLSTNGDTHLGGDDFDQVIIDWLVQEFKNDEGADLTADPMAMQRLKEAAEKAKIELSSSTSTEINLPYIMPVAGVPKHLVKTLTRAKFEQLAHDLIQACLAPCQKAMADAKLNTADIDEVILVGGSSRIPAVQTLVKNYFGKEPSKGVNPDEVVAVGASIQGAILNKEGGVGDIVLLDVTPLTLGIETMGGVMTKLIEANTTIPCKKSETFSTAADNQTEVTIHVLQGERPMASQNKSIGQFNLTGIAPARRGIPQIEVTFDIDANGILKVSAKDKATGKEQAIRIEASSGLSQDEINRMKAEAEQNAENDKKERERIDKLNQADSMIFQTENQLKELGDKIPAQHKPAIEQALQQLKDAHKAGDVAAIDTAIAALNTAWQTASQQMYQQSGAAGQPGGDQFQGGQQQAQQEGPKAEDIQDADFEEVK
>NC_014033.1|WP_049769044.1|72673_74635_-|hypothetical-protein
MTTKGNFGFIAIVTTLLVTIMLSSCSHDKYLYSEEKVEQNLNEKYAAAFEKAFGKVGSNVDWGFSSKKANTRALTRAAGTYASYKGNLQPTITFPTDCNASNFLNAVPAGVNRLPSWGGGAGNYYIDAETPSVSTYAGASTIYVTGTVDLSDSDTDANSPKFAPDYRSAIYLIEGATLKLGEVSAITLNVDAIYIAAGATLEASGLLKANNSTKIYNHGTIKVGTFETNVSGFLYNVGTLEAGNINIESNNSRIVNDGTITATNVTVKAAAIQNNAECNVTNTTKIQSTNSGWVNNGHWTTYDYAYIGGSENVINNCFLEVTHDFEMNISSAEGAFKIDAGCGVVTENFYGGRDSSSGAVSGPFKILMGENAVFKVEKTAQFECGRTGDSGYGIYGISPDGYAVFQAKDIVRDPSLASTNSHGAIIYGGNLYVSAETHFAQGDSGAGRTVIYAVDGFGIADNIYAAGFKSGKPNITIPETPCNPGFVGGSTPLYRVIAEDLSASEAGDFDFNDVVFDVVKAEGGKTTLRLICAGGVLPLRVMGIEVHGLFGETTPNEKGEYKMYNTGAGPNVDPVEFEITGEYTTPEQIKNIKIEVYKNGSWMELQATTGEAACKILVDDTFVPVPERRNIANENKKFTDYVQGTFVDEFWWK
>NC_014033.1|WP_013063531.1|72004_72499_-|acetyltransferase
MNRTITKANPQQVDDIMNVIAAAKKIMRQSGNMHQWADNYPTTDVILHDIEIGGGYVVEDDGTIVAYFAFLPSPDPTYAKIYEGNWIEDTLPYHVVHRIASYPDAHGVFKSIMDFCFAHDSNIRIDTHRDNQIMQHVILKEGFTYCGIIYLLSGDERLAYQKTK
>NC_014033.1|WP_013065292.1|71267_71993_-|DUF2461-domain-containing-protein
MDTKRILSYLKQLMANNNRDWFWEHKAEYDAVRADFEAGIEMAINRIASFDPSIAHLTVKDCTYRFNRDTRFSPDKSPYKNHFGGYIAAHGKKALHGGYYLHLEPGHCMVACGNYWLPTNILTSCRNEMMGNTAEWLKCVENKEFKKYYGSPVASSFSTPTDVSSWDQPQGFGLEKLKKCPVGFPKDWPYVEYLRMKDYCCWHQVPDDFYEGEKWLDEIERMFKAAKPMMDFMNSVIDDYE
>NC_014033.1|WP_013064392.1|70529_71264_+|MBL-fold-metallo-hydrolase
MKKLFLLLMAVLGLNTACGQSPYEVDEFTTASGKTVKFHALMHSCIRIQYDGKEIQIDPVTKLGNRSINYAAMPKADYIFVTHEHADHYDAAALKTLSADKTQLVMNKRCADMYGSGKVMANGDNLQLADVSVEAVPAYNSTVGREQFHPKGRDNGYILTIDGLRIYIAGDTEDIPEMAQIKDIDISFLPCNQPYTMTPDQLVRAAKVIKPKVLFPYHYGQTDLSSIPAQLEGTGIDVRIRHYE
>NC_014033.1|WP_013064721.1|69066_70365_-|phenylacetate--CoA-ligase
MIWNETMECMDREQLREIQSQRLVKMAEYVYYNTPFYRKKFQEMGLEPGDIKSIDDITKLPFTNKLDLRDNYPFGLAAVPMSQIVRIHASSGTTGKPVVVLYTRKDLAMWSEAISRAFTAYGAGKDDIFQVAYGYGLFTGGLGAHDGATNIGASVIPISSGNTQKQMTLMHDFGTTILCCTPSYAMFLGEAMKECPWSRDEFKLKVGVFGAEPWTEKMRKKLEESLGIKAYDIYGLSEIAGPGVGYECEHQCGTHLNEDLFYPEILDPKTGEPLPEGQFGELTFTHLTKEGMPLLRYRTHDLTALHYDKCKCGRTLVRMDRILGRCDDMLIIRGVNVFPSQIEDVILKLPEYEPHFLLTVDRVNNTDTSELKVEVKEEYFTDDMATMVGLQKKLEGELRSVIGLGFKVKLVEPKGIERSEGKAKRVIDKRNI
>NC_014033.1|WP_033151010.1|82254_83586_+|sodium:proton-antiporter-NhaD
MSTLTILIVVVFCIGYLCIALESLTKVNKAAIALLMCVLCWTLLMLDPMSYYPSLLGSDVMHHISEVIEHHLGDAAGTLFFLMGAMTIVEIVDSNGGFNFVRDAIKTRSKRKLMWRMAFMTFFLSAILDNLTTSIVMIMVLRKLVQSRNDRLIYAALVVISANSGGAFSPIGDVTTIMLWIKGVITTQGVLTEIFIPSLISMLVPAFILQYQLEGKFDKEQNLPKADVSTFTKSQRDIIFWLGVGGLCFVPIFKTITHLPPFMGILLVLGLLWTVTEIFHYSASDDDTMAKRVSDLLSRIDLSTIMFFLGILMAVAVLQEVGVLTMLGGVLDTTFEGNHFLVTGIIGVLSSIVDNVPLVAGCMGMYPVAATGDMAIDGIFWQLLAYCAGVGGSMLIIGSAAGVVVMGLEKITFGWYMKKITWVAFVGYLAGILTYWVERALFF
>NC_014033.1|WP_177168179.1|83621_86357_-|transporter-substrate-binding-domain-containing-protein
MTKKIFILAITSLLALCHVQQAAAKYIREYTTDKPLIIVSDWEFPPYEFRNDMGEPDGYNVEVLNLILDKLGIPHKFIMKEWYQCTETFDRHEADLIHCLKFKYDRPPFEYTQNMITYYNVRAVRLKGTRPLRRISQLTKNDTLTVKKNDYVDLKVAEQKSKPFRVEYHSPREALMGIRSGKYKYYMWGEQPLMMKVKELNIDGIEFDETDIPAGELRIIGYDKDLIHAIDDTFARMEQSGDIERIYDRWFHPENVHNDASPMALILLVGIIAAAIIFLLFSQVMRTRVRKAVEKSVDLNEMMQKALSSGKYYVIEFDIQTQWLKNRYGDMLPEEGMSHAVFMERLPEEDKGKFSEAMRLMSQGHKDLGYLKRRYNRGTIEKPDWHWIEGHAVVEYDEDKPRYIITSFRDYTNEVQEERMNEEIASKYQNMFEYGLIAMSFYDKDGKLIDVNRRMADLCEFDKDGEEFFRQMNLFEVPLVKGQYHKGEKENFHVCQRMFYPEIGIYKYIEIKVRPTFDENGEMQFYVVTARDMTAERHLYLEQHRHDTEIRKATENIKTYEEQLGYLLMNSNMFVWSFYTNEGIIHFSRSGRKSDYTETIEEFFAGATEEYRESGIREVYETMRQGKPYNTTIHFNHTPSEPKPVWYAISGIPSFDSSGNVCKYFGVARNINTLMEAQQKLKDETQRAEESGKMKAAFLANMTHEIRTPLNAIVGFSDLLPVVEEHSERMEFIRIIRNNCDMLMRLINDILEASNVGQALAIQPEQVDFAKVFDDICQTLAQRVDEAGVLFIKDNPYETFPATLDKGRIQQVLTNFTTNAIKYTHEGHIKVGYREQDGGIYFYCEDTGAGIPKDKQAAVFERFVKLNDFVQGTGLGLSICKAIAERCEGKIGVESEGEGHGSTFWMWIPRK
>NC_014033.1|WP_177168180.1|86375_89147_-|transporter-substrate-binding-domain-containing-protein
MNRFRIFVLLLACHLSFGTAYAQKDSIIVYNDQRPLVYEDAWDLWPYVFLNENGEPDGYNIDLLKMIFKELDIPYVIRLRPTLEAQKDLKDHKSDLMLRMDADFARNNSSYGKTIVQIFTHSLVTPKSQAIHAKAGKDLTDYSIIVHEGSFSHHKLIDNGWAKEIIPFDDMKEAIQTVSSENKGVILWNSMSLKWLMMKYHTDNLELTPFDFPYGEYKFFANDHHLLAQLDSVYSKLRANDQLTAIQNKWFYPERQESGIPSWIWDWIKFFAILALAIIIYYAFFKIREHKMTKKILRENERLSLVMRTSNVKFCTYDVDSQFFVMMDSAGYPERNYSLLEFSHRFDPNDFTQLTEALRLVIEEKVPTFTLQLKEYENDLIHSNNYTATLSVLRRDKHKKPSVIICSKTDTTQERMRQQLIKESMLRYQSLFNSAMVDMVYYDADGYITDMNSKSLAVVGVDIETIRKQHISLSDVLGIEDLDLDDFEIFYATQIYNGPDDGRILNNLLKRDKLYYELQVMPIRDNNGKRIGFFGSGRNVTEVAHSYRQLQENTNELQEAQDEVTSYVRNIDYVLAVGGISLAKYHLDTHTLTVFSEINHEKYSLTQTRALAFIAPSSEKQALRILNKMDNKQPGSLRAEIKTCIRRKDHVTLHLQFNFVPTYKDGQIVEYFGLIRDISDIKAVEEKLALESVRAQEVETVKNAFLHNMSHEIRTPLNTVVGFSELFEMDHSPEDEAVFINEIKESSASLLKLINDILFLSRLDAGMITISPQPIDLASIFEGRCSSVWDNHRQPGVEYIAQNPFKRLIVEIDEPNASMILNKILTNAIQHTTSGSVLARYEFIADRLIVSVEDTGCGIKQEDIEHIFDRFVTGANNGAGLGLSICHELVEYMGGQIELKSTEGKGTMVWFSIPCKLIEMERC
>NC_014033.1|WP_013065077.1|89149_91132_-|PAS-domain-containing-sensor-histidine-kinase
MQILIVILTLVVIIIGMILNRITLYSIRKNTWRAKDMATIMQRTLNDNNYVVRLKLQNHLAYNLYGDFLPANGMTFEQSLEYIHPDDRHFYSEFIIRLVKGAESSECIFRWDSSLDKHEEQWRYIHDIGIVEYDYDDKKTPINFYCILDDQTDQILTEKEERELTDRYRKLFEQSIVGQAFYDKDGHLLTANHKLREILKFKTEDDPFYHRYSLFELPTFRYILRKDLTDDLYFCTKTVMYERGVNCYSEIRIHPIFNEDHQLEFFTLYMRDVTQERELYQQDKENEASLQRTNQAIEQYETELKYLMENVDMHFFRTSFEKREVTFYREMSVIESKMGFDELITHFIDDPFAEGLRHPYEFFNEPKSTLTHMRPFFHDSDELEWTFIDSIPYYDENGKQTGTYGVVRNVTDLIYKQEQLKEETERANQAGMRKSTFLASMSHEIRTPLNAIVGFSDVLATMSTPEEREGIIQVISNNCDMLLRLVNDILALSSLESGDIIVKPTRTDFAKCFNSVATSLAQRIKNPKIEFLVESPYPTYITTIDGGRTQQIVTNFVTNAIKYTQQGHIKIGYEQQMRQDKEGLYIYCEDTGAGIPKEHQGKVFDRFVKLNDFVQGTGLGLSICKLIADNSGGEIGVTSEGKDCGSTFWVWIPCKQEITE
>NC_014033.1|WP_187288014.1|91133_93035_-|PAS-domain-containing-sensor-histidine-kinase
MQLTLIMDANKTDTWTYHTKKNIFKVISKQDLTETLYTPFDFSQLYDRDDFKKIQKAITNIQNRETLSETLTVKSAPNKDGLVKCYEITLSVLHRNRHDMPSEILGTQRDITLEQQRAENTRKLMLRYHTVFNSSLVDMIYYDADGYLADLNDKACETFGVKNPQALLDRQMKMTDIPSYREMDVRTIEHTQLSSITDISQTKATDERVPEVTRQGKIYYEVMLGPIRNEDNQLYGVIAAGRDITEMVESTHKQKEASKLIEKRTKDIQQYIRDINYSLRISEARLVNYYPDTHELEILSDLTETGKRIAQLHAVALIHSDDRPKAKHLILHMDKRRLGTISETLHTKLPDKQGRDIYLNFNLMPITNHDGIVTHYFGLLRNDTEMSYTEMRLQEETAKAQEEEQLKNAFLLNMSYELRVPLHAVIGFADLFKTEHSLEDEPIFANEIKKNTDVLLNLINDILFISRLDAHMIEYNYEVHDFATLFDSWCQHGWSETSNDARKIINNSYKSLRVKIDKHNLGIAIEKLCNYVGLSTNEGLIKSRYEYLHDELIVIVDSTDGGMDLEDATKMFDRFVSDGKNKRIGTGLDLPIVKEMIEQMGGTIDVLSEPDKGSSFFIALPCEMIDFERKIVI
>NC_014033.1|WP_013064196.1|93321_93882_+|ribosome-recycling-factor
MVDVKEILNKSEERMEMAAMYLEEELNRIRAGRANVAILDAVRVEVYGSKVPLNQVANVSVPDPRTIAIKPWDRKEIRNIEKAIMDSDVGITPENNGEIIRLNIPQPTEERRRDLTKQCNKIAEKAKVEVRNVRGDIKDKLKKAIKDGLSEDLEKDAEAELQKLHDKFIKKIDELITAKNKEIMTV
>NC_014033.1|WP_013064802.1|93882_94812_+|ribosome-small-subunit-dependent-GTPase-A
MRGLVIKNTGSWYTVLTDDGQLIECKIKGNFRLKGIRSTNPVAVGDRVEIVPNNEGTAFITEIEDRRNYIIRKSINLSKQSHILAANVDQAILVVTVVNPQTSTTFIDRFLASAEAYRVPVILVFNKTDLLDEDTRRYQEAMVHLYQTIGYECYQISAETGAGVEALQPLLKDKITLLSGNSGVGKSTLINRLVPGASQRTAEISDAHNTGQHTTTFSEMIRLDEGWLIDTPGIKGFGTFDMEPEELTSYFKEIFRFSQDCKFSNCTHTHEPGCAVLKALEDHYIAESRYQSYLSMLEDKDEGKYRAAY
>NC_014033.1|WP_041385473.1|94822_97267_+|S9-family-peptidase
MKRLITTQMLLAIGMMATAQVKTPVTEFNLAGPYAVSAPFAIDTVDVQGKKFDPVSQLGSIALTSHFTGKFSGQVLPSLPDSKSVGLLSFYVNNSDFIKGKIEVKGPKHSKLFIDGVEAGGELKLAPEHHTFTIQYLAEPKDTDSVQVVFDTPTSITYQLTPNHPYMVHDLTDGKRVRGINLSADGQFVCVSYQTTDRGGNTRWNYELRDVKSGRLISQPSRNPRWMPKSIAWLEEEKEGSHRVLYKVDPKTGVRTRFAYDIPEGSYTVSPTEDYLIFTLEEEGPQEDKEVFEILEMDDRQPGWRKRNYLAKYDIKTGITQRITFGNKGEYLYDISQDGSKLLVISNRSRLTKRPTTVSDVFVMDAHTLKVDTLLSGAEFLGGGSFSPDGSQILFVGNPEAFNRIGCQLPAEVTPSMTENELFLFDIASKQVKPLTKDFDPSIDDVDWSWADGQIYFSAEDRDYVNMFVLNPKTGIITKLPVKGDYTYRFNMAAHAPVLAYLSYKTMEPASAYIATIKNAKFNAHSSMFNGKEALGDAEIGTCQDCNFTNSKGDTVYGRLYLPKDFDATKKYPMIVYYYGGCSPVSRYFESPYAPQYWNSLGYVAYILEPSGATGFGQEWASRHVNTAGRGPAEDIIEGTKKICEAHPFINKDKIGCMGASYGGFMTQYLQTQTDIFAAAVSHAGIANHTSYWGEGYWGYNYSEVSMANSYPWSHRQLYVDQSPLFNADKIHTPLLLLHGNADTNVPLIESLQMFTALKLLGREVSLVEVEGENHHILDYSKKEKWLATQMAWFQKWLKDDPTWWDALYPKKHL
>NC_014033.1|WP_013065715.1|97306_98386_-|tRNA-2-thiouridine(34)-synthase-MnmA
MNIKDIENKRIAVLLSGGVDSSVVVYEFARMGLHPDCFYIKIGPEEEEEWDCSSEEDLEMATAVSHKFGCKLEVIDCHNEYWDQVTKYTMDKVRAGLTPNPDVMCNRLIKFGAFDEKRGHDYDLIATGHYAMTETDENGDKWLCTSPDPVKDQTDFLAQIADWQLKKALFPIGHYVKDEVRVIAEREHLVNAKRKDSQGICFLGKINYNDYIRRYLGEQPGDVIELETGKRIGEHKGLWFHTIGQRKGMGFGGGPWFVVKKDVANNILYVSHGYDPETAYKADFPVHDFHFLTKELQPTKITFKIRHTPEYHPATLEWTSPSTCMVHSKDKIHGVAPGQFCVVYDKDHHRCLGSGEITI
>NC_014033.1|WP_041385474.1|98553_99519_+|SPFH-domain-containing-protein
MENKECTFNGMVLNGFLMLFVTIALALANIYAGIKWIILLTDTDGANGGWQLLCCAVLLIVSIVLMCGFLMLEPNEARVLTFFGKYRGTFTRTGYFWVNPLLSSKKVSLRARNLDAEPIKVNDKTGNPVMIGLVLVWKLKDTYKALFEVDTQTMAANPAAIGSDTKGLMNALENFVRVQSDAALRQVAGQYAYDDEDTKTGEPTLRSSADEINEQLEQKLDERLALAGIEVVEARINYLAYAPEIAAVMLRRQQASAIITAREKIVEGAVSMVKMALDKLSNEEIVELDDDKKAAMVSNLLVVLCGDDNAQPVVNTGTLNH

Crispr_ID: NC_014033_2

• CRISPR_ID: NC_014033_2
• CRISPR_location: 778634-778737
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014033_2

Consensus_repeat	Method
CCCTCTCGGGATTCTGCCCGGATAG	CRISPRCasFinder

spacers of NC_014033_2

>2.1|778659|54|NC_014033|CRISPRCasFinder
TCAAAAAGCACCTTTGGCAAAAAAATAATGGAGTAGTGTCGATAAAGTCTTGCT

CRISPR arrays and Neighbor proteins around NC_014033_2

CRISPR arrays

The CRISPR arrays of NC_014033_2

>merge|NC_014033|2|778634-778737|CRISPRCasFinder
CCCTCTCGGGATTCTGCCCGGATAGTCAAAAAGCACCTTTGGCAAAAAAATAATGGAGTAGTGTCGATAAAGTCTTGCTCCCTCGCGGGATTCTGCCCGGATAG

>NC_014033|2|2|778634-778737|CRISPRCasFinder
CCCTCTCGGGATTCTGCCCGGATAG	TCAAAAAGCACCTTTGGCAAAAAAATAATGGAGTAGTGTCGATAAAGTCTTGCT
CCCTCGCGGGATTCTGCCCGGATAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014033.1|WP_080517223.1|784895_785339_+|HNH-endonuclease	unknown	unknown	gnl|CDD|379157
NC_014033.1|WP_041385619.1|785972_786242_+|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_041385611.1|773669_775340_-|putative-transporter	unknown	unknown	gnl|CDD|179654
NC_014033.1|WP_013063197.1|778049_778436_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl|CDD|239517
NC_014033.1|WP_013065375.1|764673_765087_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013064476.1|782366_783713_+|DNA-cytosine-methyltransferase	unknown	unknown	gnl|CDD|238192
NC_014033.1|WP_013064489.1|767939_768368_+|acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|223894
NC_014033.1|WP_013063598.1|772753_773668_+|glutaminase	unknown	unknown	gnl|CDD|274797
NC_014033.1|WP_041385614.1|779240_779861_+|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013063702.1|781263_782370_+|HindVP-family-restriction-endonuclease	unknown	unknown	gnl|CDD|370544
NC_014033.1|WP_033151324.1|786439_786859_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013065062.1|769021_770197_+|glycoside-hydrolase	unknown	unknown	gnl|CDD|366376
NC_014033.1|WP_013065588.1|783719_784328_+|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_041385613.1|778827_779064_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013063308.1|780047_780437_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl|CDD|239517
NC_014033.1|WP_170857894.1|775548_775710_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_041385617.1|780962_781211_+|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_143040072.1|775796_777635_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_041385607.1|765477_767574_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_041385608.1|770366_772409_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014033.1|WP_013063702.1|781263_782370_+|HindVP-family-restriction-endonuclease	gnl|CDD|370544	pfam09519, RE_HindVP, HindVP restriction endonuclease. This family includes the HindVP (recognizes GRCGYC bu the cleavage site is unknown) restriction endonucleases.	6.24503e-180
NC_014033.1|WP_041385611.1|773669_775340_-|putative-transporter	gnl|CDD|179654	PRK03818, PRK03818, putative transporter; Validated.	0
NC_014033.1|WP_013064489.1|767939_768368_+|acyl-CoA-thioesterase	gnl|CDD|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	2.80713e-26
NC_014033.1|WP_013063308.1|780047_780437_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	gnl|CDD|239517	cd03425, MutT_pyrophosphohydrolase, The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). This enzyme requires two divalent cations for activity; one coordinates the phosphoryl groups of the NTP/dNTP substrate, and the other coordinates to the enzyme. It also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as metal binding and catalytic site. MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides.	2.96528e-51
NC_014033.1|WP_013063197.1|778049_778436_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	gnl|CDD|239517	cd03425, MutT_pyrophosphohydrolase, The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). This enzyme requires two divalent cations for activity; one coordinates the phosphoryl groups of the NTP/dNTP substrate, and the other coordinates to the enzyme. It also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as metal binding and catalytic site. MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides.	1.00704e-49
NC_014033.1|WP_013064476.1|782366_783713_+|DNA-cytosine-methyltransferase	gnl|CDD|238192	cd00315, Cyt_C5_DNA_methylase, Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.	3.75357e-83
NC_014033.1|WP_013063598.1|772753_773668_+|glutaminase	gnl|CDD|274797	TIGR03814, Glutaminase_1, glutaminase A. This family describes the enzyme glutaminase, from a larger family that includes serine-dependent beta-lactamases and penicillin-binding proteins. Many bacteria have two isozymes. This model is based on selected known glutaminases and their homologs within prokaryotes, with the exclusion of highly-derived (long branch) and architecturally varied homologs, so as to achieve conservative assignments. A sharp drop in scores occurs below 250, and cutoffs are set accordingly. The enzyme converts glutamine to glutamate, with the release of ammonia. Members tend to be described as glutaminase A (glsA), where B (glsB) is unknown and may not be homologous (as in Rhizobium etli). Some species have two isozymes that may both be designated A (GlsA1 and GlsA2). [Energy metabolism, Amino acids and amines].	2.73489e-164
NC_014033.1|WP_013065062.1|769021_770197_+|glycoside-hydrolase	gnl|CDD|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	1.3059e-81
NC_014033.1|WP_080517223.1|784895_785339_+|HNH-endonuclease	gnl|CDD|379157	pfam13391, HNH_2, HNH endonuclease.	8.45345e-14

Protein sequences

>NC_014033.1|WP_013063197.1|778049_778436_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase
MKQIEVVAAIIRKDDKVFATQRGYGEWKDWWEFPGGKVEPGETPEAALKREIREELSTEISVDTFVCTVDYDYPKFHLTMHCYYCSLLDEALHLNEHEAARWLTLEQLDSVDWLPADLVVVEDIKKGE
>NC_014033.1|WP_143040072.1|775796_777635_-|hypothetical-protein
MKRKRLIWLLAGAIAFCSTSMMQTSCTKAEDNPVMPEEGTSGMVGGNEFTPTQLIKTYIYVAPGVDPDVKQAIDWASKGAIDQLSETLSIPVYVVNKLTDLSDEQMDDIMYSGETVLLMNPVESEIKAYLETHDYITLDPEITDSTWILGFNNNTKILIDKLSQTGDPVADNANRNEKAYVALSGVFTAFAERYEGYTGAFGGDDKEDTKKMENLFASYHFVHVNSYSAHVHYDTTWGEKYYLDGTGSATTLLDVYPVHVYEGQAGAGDYFAVKMNTSVANAGMWKGKGWNRRVGIYIRHCGLWATNFDTQVVPMKDENTVMPQTELQFLAACPPTPGTTTNQKYYEDSKSFSLNVSATGKLEAGEEAKPGEEPTAKKSKSLQVQLSMGWNWTHKESYAIQNVEIEDRHAGNSIDWNIKFNDLPHYDWDEDYGFKITESLPYRNTQALNASWMWYDPNAKDESDTKPLLIKVTTNPQYEMQTFWTTKADLKSVYYNHSKTEFFKIPRPNNKHAGELVIKNDLKDDAYISDIRVYRKGTNIMVGNYSMSVPNGEEQTLGHYLSNNQAYIVTFKATFGDGSTAYYTYSLNDGIKVTHNTTTKLYARNDFTAEGA
>NC_014033.1|WP_170857894.1|775548_775710_-|hypothetical-protein
MRLQSCSSNPLVDAAYNAEEGDAGNHASRTAEKDAHCLHIIADNFIGGVDIKN
>NC_014033.1|WP_041385611.1|773669_775340_-|putative-transporter
MEWINNLIFNPSAMQTVVVLSLICALGLALGKIRVMGISLGVAFVFFVGILAGHFGFEVDSRMLDYAQSFGLILFVYCLGLSVGPGFFGSLAHEGVTLNLWGLAVILIGTAMAVCLCPLTGISMPDMAGLLCGATTNTPALGAAQQTLSQLGIPHSGTALGCAVTYPLGVVGVILAILFMRKFFVRPADLMPRSISEENETYIARFNVVNPAIVGKSLEEIATMTHLRFIISRIWRGDEVIVPKSTTQLQLDDRLMVVTKKEDASMLEILIGLHVEEPEDWNSEKVDWNALDNKMESRVVVLTKPILNGRRLGSLKIRHTYRVNISRITRGDIKLLATPDLRLQYGDRLHIVGDPKSVDAVEAFFGNSVQSLNEPNLAAIFIGIILGLALGSLPLQLPGMSIPVRLGIAGGPIVVGIIVGAFGPRFHLITYTTRSASLMLRKLGLSLYLASLGLDSGAQFFETVIRPEGILWICIGFALTVVPVLLVGMAALRSHKFDYGTICGILSGSMANPMALAYVNDTIEGNSPSVSYATVYPLGMFARVILVQMLLMIAGG
>NC_014033.1|WP_013063598.1|772753_773668_+|glutaminase
MDYGQIIDKVYTACLPFANEGRQADYIPMLAEVDAKQFGLCLLTLDGNVYEQGNTRTRFSLQSISKVFALAMCLSQEADRLWQRMGKEPSGNAFNSLVQLEYEHGIPRNPFINAGAIVMADVLLSTLSRPEEQFLTFVRSLSGSSTVGFNRRVAQSEQSCGYLNAAIANLLKYHGNIRGDITRVLEFYFLMCSVEMSCHELAHAFLPFANHRQPFNYGGVSLTSSQVKRINAIMQTCGFYDEAGEFSYRVGLPGKSGVGGGIAAIHPLHYAVATWSPRLNIKGNSVMGMKALELLTSETEESIF
>NC_014033.1|WP_041385608.1|770366_772409_+|hypothetical-protein
MLEYTYNYKLHIAFQNLMEDYRVDAWSGIHKLFSSYRDVLPWIYRDKRRYKFENVGISCPADVSDFLHQFGKKYKAYISQHAVDFEAQSEKELIETVSILFRNELEKQQLYDADVIDALRAIYPDYTLFARDLLYYPYQVCNIIFVYNEKYALACLDMILNICSKIKETLKARALFHGNYDDFVDAVKWLSYYRDNNNVRLVHFANITPDKDSLLRHAFEETLSRYDNKTQSVIVKGEIDYLEFMCFLKNENELFRLSRVGIERFQQLKKLLADFEPIYHKILFDNTDNVRYNLCKYQFHFLSNDDVEFVSQFYGKHHHYPMFYILCRYFNTTTNNNAKIFASYCGLGDEATLAAARSKFSRERIRQIIGIKSFADQDYKNVMNPQWWQPYNLSFTGVLTPKMSQFKNISRREHLSISFNTYACLANLFQDSRVLHFTTRYTDIGIGKISAYINGNQPFHTCIYDAKYLNFNFFSAFEDFEIMVRKYRKNTDKISLLPFVSNPKYWREGKVISADSVEHFLYVFECIIKDFWGVSVQDHYVQLPANRIDYAEIFYNIIKDNGKGMFVNDIFARYKQLYPRSKYKTPLQIKPYLFKDERLINIGKTTIYSLVEWGVFSGSLFDLVVDVVAQSDSPVRVRDLISQVLERRPSSTKRSVENIIYLCVKDGRLVRVGKALIDIP
>NC_014033.1|WP_013065062.1|769021_770197_+|glycoside-hydrolase
MKIFKTWITAAVLFGGLLLTACTNDDNPSGSSAGSVEEQLRKMTLREKVGQMFYVRPEALDTTIHWSSFEELSPYKLQQINDCMAGVVKNYPIGGMILYAWNIEDENQLSSFISQIRALNGSPLLCIDEEGGRVSRLANHPNFNLPKYESMESIGETGDPANAYECANTIGTYLTRYGFDIDFAPVADVNTNPDNVVIGKRAFSSDPAVAASMVTSYLQGLKDAGITGCIKHFPGHGDTTADTHYGYAKSMKTWDEMMDCEMVTFRAGIAWGCELIMTAHIATPNVTGTDEPATMSPVILKDKLRGELGYRNIIVTDAISMGAITKQYTNAEAAVGCIKAGADIVLDPRNLVEAFDAVIAAVNDGTLSEARINQSVRRILTLKQQIRNRTK
>NC_014033.1|WP_013064489.1|767939_768368_+|acyl-CoA-thioesterase
MAQEVNNGYRHILPIQIRFNDVDKFGHVNNTVYFQFYDTAKTEYFATVCEDVDWERVAIVVAKIEADFVSQIKAGDHIAARTRTMKIGNKSFHLEQDIIDVDTLEVKCRCASVMVLYDLEHHQTMPFPEAWRQAIRQYDGLE
>NC_014033.1|WP_041385607.1|765477_767574_-|hypothetical-protein
MKTKRSYYLMLTLIMVAGLSTTSCVQNDNPIVADVSSGVQSNKAKEPTTDRMGVLVTADVPTAVIGTFDEGTTGASLVKRLPKTTASIDADTRMVILSGSMFDNMAAALDPEVMKAAVRLTMDGGYICLTNPTNEQAGAFGLTYLLSLLALEEADIEQLFDITSEEAAEAAQSSPRLERMKMRMANMQRVARTRADDEDMDMNAPFAEMIILGSNDYFMQEPFVENFTSYVSESDENGNSTDPQVVTGKMTRTAAISGMLADAAAQWLNDTEKSYQQAAARRSMTRASGSSNINELMNASETFTYNGSICFTDDDASTKRRNNRVNMKVSSWGVHNIDANKDYYYLKQNVTLCMGNRNGSKIFYPTRGEDYWYNATNFGEYNRWYGAFLSKYDTSMDLTGSGSIHLEAAAPNTDNNSSTTTVTTGTSHSTTETVGITWGASGGANAAGPMGSFSVGGSYSVGTTNGSSFSVGMSQTTKELGVKKNTVGTKVAWTYTGALPQYYEKVGDRISYCHQMPAAILVNDADVSQEICWSVDNPSGQYTVNITSSPQTAVLMHVYKKEDGYKNAPRKYVYNNDADATYTHNLLEPNRAMQSWRMYITIDEWVSSPIVGAQGELESNIRNAFPDLYASTFRIADKTATSLNTIGYIVKASKEIMTKNVDILQSYARSWGIKKFTIHWRCDDRNVTTREGLTIIAD
>NC_014033.1|WP_013065375.1|764673_765087_-|hypothetical-protein
MMEIRKIEKSDLVLFPRLQKPGLKPKHVAFESFKAELKHIEGHGSYWLLYQQDKPHLVVHVQLPKSEAEFDNILGWCLGQNKWCDYIEADLSFICVIAGYNAEELTPKYPDFFKERVYALYNSVYWWYKYGKALLKQ
>NC_014033.1|WP_041385613.1|778827_779064_-|hypothetical-protein
MEKKWISTEQMLEALKSDPDNEHEYTHYLGGCFRSTHWWIYDSAKDEFLGSTNWNDYTNFTESEMLSIYGGQWWHRDA
>NC_014033.1|WP_041385614.1|779240_779861_+|hypothetical-protein
MIQEDIVEYEILEEDFSSEWIVSEPPTRDLDTLLEDLHSLHGSAFVTQLKYIAAHRAFTPISGETGIYSVGGEQDADFENLLNAARKAVEHGYRVFILPNPKGIRTADFIFEKKSNYKMYDLKTIIGQSSVVNRLFESIGQSNRVLLNINTEYNARLLASDIKSYFEVNDDAVEVLIFKGKKVISVNRVGVGSTNFNRVFRKKYEK
>NC_014033.1|WP_013063308.1|780047_780437_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase
MKQIEVVAAIIHDEAGRIFATQRGYGDMKDGWEFPGGKMEPGETPEESLKREIWEELETNITVERLVKTVEWDYPKFHLTMHCFWCSVVSGALTLKEHEAARWLTIDQLDCVDWLPADLVVVEDIKKEE
>NC_014033.1|WP_041385617.1|780962_781211_+|hypothetical-protein
MANRNVILLHLLESDTYEFFGSPASLFDKHEANELLIAQTSLNNHFSKMAAQGKELVYRNAYCEIRKGEIYVKPSTRGRKKF
>NC_014033.1|WP_013063702.1|781263_782370_+|HindVP-family-restriction-endonuclease
MAKKDTKEVACFVEGVLPGLFGQKYSSRDYRYEDSWGKNQFNSSFPASLVAYMGSKGVNPIYICTNKKNEVVHKTINTTDLFGVNPLGEDAYYNYEAEYYPYEQFYYAAKKEKIDLVMINRSTEVAASGLEVKLTTLPDNTTKDLEESEYGSEIVVRSPTILFLACSICSCYNSEKGKNRLHSILNTIGSEIKNWSEIRQVLPHYKAICKAILDVSIDLSNKQIPLIIQPIWKTDKKLKDFADDCLDVFVWSNLSVIQMCLRETNADNDISRNQRTIIWLYKMLWDFSLYGSFNYTGIVNELAYNYKTDKAFSISGKLTNPLMRCPELTKPRISKYEIKNIILGDGQKLLSPERRFDAFIVSHPELFK
>NC_014033.1|WP_013064476.1|782366_783713_+|DNA-cytosine-methyltransferase
MKVVDLFCGCGGLSLGFQKAGFNILAAFDNWDDAITVYHANFKHPVIKQDLSNVDQTVEKVKKYKPDMIIGGPPCQDFSSAGKRDENNGRGDLTINYAQVIAALKPDWFVMENVDRITKTEKLVEAKTIFKQCGYGLTYAILNASRCGAPQRRKRFIMIGHLGEEDGFMSNILELRQSDKEMTVADYFGSQLDIQYYYRHPRSYARRGIFSVNEPSPTIRGVNRPMPAGYQLHSNDPVKSLEGIRPLTTLERSMIQTFPKDFRFLGNKTNMEQMIGNAVPVNLARYVGECIMAYLGNNNPVNYEQLREDYPEKIVNNSSVSINPELKVDKEKNVLISLVKNDNVDLFLDGSARIYYTGKKFPSTVALNKLYYFMPYVKQKGIRDIYLIKIARVGSKHEIHPDADENDLRLVFEIEKIGQLFDDYKPVELKIWHTFTDTTIKSVLSNRL
>NC_014033.1|WP_013065588.1|783719_784328_+|hypothetical-protein
MVAKSKQQRLNEEIAYELDKYQVMLEYGRMCLDDDKAIRKKYAWMNYVKNGCLSGMAIDLIMAGATKLISSEFFGVYLPYFLIVFFLVLIMYIFFFFIHRKQIAKLIGAEEKATLKELLDNLRSYLHKLGEWMKEVDCHIEQEKSVLDIIEKELAVAKSQQAKEVNKLSEIYGNLDEKMDDKAHQMAEERLIQYKRFIYDYE
>NC_014033.1|WP_080517223.1|784895_785339_+|HNH-endonuclease
MAHYDITKEGEDVIYEAKRRKGQNYFRFMVLDNYGSRCALTGIDIPELLLASHIIPWSDKKHKSDRLNPCNGICLSALYDKAFDKGLITFKDDLTALFSNKLEANVGKEYFKQYFEPIRNKKLITPRKYLPSPEFLEWHRDCIFSKE
>NC_014033.1|WP_041385619.1|785972_786242_+|hypothetical-protein
MIACLIWVLLYAFIIWMLAAITSWWAVIIMHIGAVIFLLIYKGDAIFRGSNPPENPDDKTCDDESYRAAREERDAYDDYIASIDMDKDR
>NC_014033.1|WP_033151324.1|786439_786859_-|hypothetical-protein
MNKLIVSALLCLASITASAQNTQGPFRAYLINKELDIVMRINFYQQDVTVPGQDLFGQVPGYLSKRFNSFAWVITDAEVKGHKATLQMINDYGSEDLTATLTAKGDSVFILKQESGSALKVPFKGKWQKLPKTIEFRRQ

Crispr_ID: NC_014033_3

• CRISPR_ID: NC_014033_3
• CRISPR_location: 780632-780735
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014033_3

Consensus_repeat	Method
CCCTCTCGGGATTCTGCCCGGATAG	CRISPRCasFinder

spacers of NC_014033_3

>3.1|780657|54|NC_014033|CRISPRCasFinder
TCAAAAAGCACCTTTGGCAAAAAAATAATGGAGTAGTGTCGATAAAGTCTTGCT

CRISPR arrays and Neighbor proteins around NC_014033_3

CRISPR arrays

The CRISPR arrays of NC_014033_3

>merge|NC_014033|3|780632-780735|CRISPRCasFinder
CCCTCTCGGGATTCTGCCCGGATAGTCAAAAAGCACCTTTGGCAAAAAAATAATGGAGTAGTGTCGATAAAGTCTTGCTCCCTCGCGGGATTCTGCCCGGATAG

>NC_014033|3|3|780632-780735|CRISPRCasFinder
CCCTCTCGGGATTCTGCCCGGATAG	TCAAAAAGCACCTTTGGCAAAAAAATAATGGAGTAGTGTCGATAAAGTCTTGCT
CCCTCGCGGGATTCTGCCCGGATAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014033.1|WP_013064685.1|787000_788713_+|glycogen/starch-synthase	unknown	unknown	gnl|CDD|340824
NC_014033.1|WP_080517223.1|784895_785339_+|HNH-endonuclease	unknown	unknown	gnl|CDD|379157
NC_014033.1|WP_041385619.1|785972_786242_+|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_041385611.1|773669_775340_-|putative-transporter	unknown	unknown	gnl|CDD|179654
NC_014033.1|WP_041385613.1|778827_779064_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013064476.1|782366_783713_+|DNA-cytosine-methyltransferase	unknown	unknown	gnl|CDD|238192
NC_014033.1|WP_013063197.1|778049_778436_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl|CDD|239517
NC_014033.1|WP_013063598.1|772753_773668_+|glutaminase	unknown	unknown	gnl|CDD|274797
NC_014033.1|WP_013064138.1|788786_791366_+|alpha-glucan-family-phosphorylase	unknown	unknown	gnl|CDD|340852
NC_014033.1|WP_013063702.1|781263_782370_+|HindVP-family-restriction-endonuclease	unknown	unknown	gnl|CDD|370544
NC_014033.1|WP_013065062.1|769021_770197_+|glycoside-hydrolase	unknown	unknown	gnl|CDD|366376
NC_014033.1|WP_013065588.1|783719_784328_+|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_041385614.1|779240_779861_+|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013063308.1|780047_780437_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl|CDD|239517
NC_014033.1|WP_013063625.1|791400_791973_-|DUF4369-domain-containing-protein	unknown	unknown	gnl|CDD|379543
NC_014033.1|WP_170857894.1|775548_775710_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_041385617.1|780962_781211_+|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_143040072.1|775796_777635_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_033151324.1|786439_786859_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_041385608.1|770366_772409_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014033.1|WP_013064685.1|787000_788713_+|glycogen/starch-synthase	gnl|CDD|340824	cd03793, GT3_GSY2-like, glycogen synthase GSY2 and similar proteins. Glycogen synthase, which is most closely related to the GT3 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the member of this family in S. cerevisiae, has been shown to possess glycogen synthase activity.	8.13763e-90
NC_014033.1|WP_013063702.1|781263_782370_+|HindVP-family-restriction-endonuclease	gnl|CDD|370544	pfam09519, RE_HindVP, HindVP restriction endonuclease. This family includes the HindVP (recognizes GRCGYC bu the cleavage site is unknown) restriction endonucleases.	6.24503e-180
NC_014033.1|WP_013063625.1|791400_791973_-|DUF4369-domain-containing-protein	gnl|CDD|379543	pfam14289, DUF4369, Domain of unknown function (DUF4369). This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with pfam00578.	4.34763e-12
NC_014033.1|WP_041385611.1|773669_775340_-|putative-transporter	gnl|CDD|179654	PRK03818, PRK03818, putative transporter; Validated.	0
NC_014033.1|WP_013064138.1|788786_791366_+|alpha-glucan-family-phosphorylase	gnl|CDD|340852	cd04299, GT35_Glycogen_Phosphorylase-like, proteins similar to glycogen phosphorylase. This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism.	0
NC_014033.1|WP_080517223.1|784895_785339_+|HNH-endonuclease	gnl|CDD|379157	pfam13391, HNH_2, HNH endonuclease.	8.45345e-14
NC_014033.1|WP_013063308.1|780047_780437_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	gnl|CDD|239517	cd03425, MutT_pyrophosphohydrolase, The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). This enzyme requires two divalent cations for activity; one coordinates the phosphoryl groups of the NTP/dNTP substrate, and the other coordinates to the enzyme. It also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as metal binding and catalytic site. MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides.	2.96528e-51
NC_014033.1|WP_013063197.1|778049_778436_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	gnl|CDD|239517	cd03425, MutT_pyrophosphohydrolase, The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). This enzyme requires two divalent cations for activity; one coordinates the phosphoryl groups of the NTP/dNTP substrate, and the other coordinates to the enzyme. It also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as metal binding and catalytic site. MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides.	1.00704e-49
NC_014033.1|WP_013064476.1|782366_783713_+|DNA-cytosine-methyltransferase	gnl|CDD|238192	cd00315, Cyt_C5_DNA_methylase, Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.	3.75357e-83
NC_014033.1|WP_013063598.1|772753_773668_+|glutaminase	gnl|CDD|274797	TIGR03814, Glutaminase_1, glutaminase A. This family describes the enzyme glutaminase, from a larger family that includes serine-dependent beta-lactamases and penicillin-binding proteins. Many bacteria have two isozymes. This model is based on selected known glutaminases and their homologs within prokaryotes, with the exclusion of highly-derived (long branch) and architecturally varied homologs, so as to achieve conservative assignments. A sharp drop in scores occurs below 250, and cutoffs are set accordingly. The enzyme converts glutamine to glutamate, with the release of ammonia. Members tend to be described as glutaminase A (glsA), where B (glsB) is unknown and may not be homologous (as in Rhizobium etli). Some species have two isozymes that may both be designated A (GlsA1 and GlsA2). [Energy metabolism, Amino acids and amines].	2.73489e-164
NC_014033.1|WP_013065062.1|769021_770197_+|glycoside-hydrolase	gnl|CDD|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	1.3059e-81

Protein sequences

>NC_014033.1|WP_013063308.1|780047_780437_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase
MKQIEVVAAIIHDEAGRIFATQRGYGDMKDGWEFPGGKMEPGETPEESLKREIWEELETNITVERLVKTVEWDYPKFHLTMHCFWCSVVSGALTLKEHEAARWLTIDQLDCVDWLPADLVVVEDIKKEE
>NC_014033.1|WP_041385614.1|779240_779861_+|hypothetical-protein
MIQEDIVEYEILEEDFSSEWIVSEPPTRDLDTLLEDLHSLHGSAFVTQLKYIAAHRAFTPISGETGIYSVGGEQDADFENLLNAARKAVEHGYRVFILPNPKGIRTADFIFEKKSNYKMYDLKTIIGQSSVVNRLFESIGQSNRVLLNINTEYNARLLASDIKSYFEVNDDAVEVLIFKGKKVISVNRVGVGSTNFNRVFRKKYEK
>NC_014033.1|WP_041385613.1|778827_779064_-|hypothetical-protein
MEKKWISTEQMLEALKSDPDNEHEYTHYLGGCFRSTHWWIYDSAKDEFLGSTNWNDYTNFTESEMLSIYGGQWWHRDA
>NC_014033.1|WP_013063197.1|778049_778436_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase
MKQIEVVAAIIRKDDKVFATQRGYGEWKDWWEFPGGKVEPGETPEAALKREIREELSTEISVDTFVCTVDYDYPKFHLTMHCYYCSLLDEALHLNEHEAARWLTLEQLDSVDWLPADLVVVEDIKKGE
>NC_014033.1|WP_143040072.1|775796_777635_-|hypothetical-protein
MKRKRLIWLLAGAIAFCSTSMMQTSCTKAEDNPVMPEEGTSGMVGGNEFTPTQLIKTYIYVAPGVDPDVKQAIDWASKGAIDQLSETLSIPVYVVNKLTDLSDEQMDDIMYSGETVLLMNPVESEIKAYLETHDYITLDPEITDSTWILGFNNNTKILIDKLSQTGDPVADNANRNEKAYVALSGVFTAFAERYEGYTGAFGGDDKEDTKKMENLFASYHFVHVNSYSAHVHYDTTWGEKYYLDGTGSATTLLDVYPVHVYEGQAGAGDYFAVKMNTSVANAGMWKGKGWNRRVGIYIRHCGLWATNFDTQVVPMKDENTVMPQTELQFLAACPPTPGTTTNQKYYEDSKSFSLNVSATGKLEAGEEAKPGEEPTAKKSKSLQVQLSMGWNWTHKESYAIQNVEIEDRHAGNSIDWNIKFNDLPHYDWDEDYGFKITESLPYRNTQALNASWMWYDPNAKDESDTKPLLIKVTTNPQYEMQTFWTTKADLKSVYYNHSKTEFFKIPRPNNKHAGELVIKNDLKDDAYISDIRVYRKGTNIMVGNYSMSVPNGEEQTLGHYLSNNQAYIVTFKATFGDGSTAYYTYSLNDGIKVTHNTTTKLYARNDFTAEGA
>NC_014033.1|WP_170857894.1|775548_775710_-|hypothetical-protein
MRLQSCSSNPLVDAAYNAEEGDAGNHASRTAEKDAHCLHIIADNFIGGVDIKN
>NC_014033.1|WP_041385611.1|773669_775340_-|putative-transporter
MEWINNLIFNPSAMQTVVVLSLICALGLALGKIRVMGISLGVAFVFFVGILAGHFGFEVDSRMLDYAQSFGLILFVYCLGLSVGPGFFGSLAHEGVTLNLWGLAVILIGTAMAVCLCPLTGISMPDMAGLLCGATTNTPALGAAQQTLSQLGIPHSGTALGCAVTYPLGVVGVILAILFMRKFFVRPADLMPRSISEENETYIARFNVVNPAIVGKSLEEIATMTHLRFIISRIWRGDEVIVPKSTTQLQLDDRLMVVTKKEDASMLEILIGLHVEEPEDWNSEKVDWNALDNKMESRVVVLTKPILNGRRLGSLKIRHTYRVNISRITRGDIKLLATPDLRLQYGDRLHIVGDPKSVDAVEAFFGNSVQSLNEPNLAAIFIGIILGLALGSLPLQLPGMSIPVRLGIAGGPIVVGIIVGAFGPRFHLITYTTRSASLMLRKLGLSLYLASLGLDSGAQFFETVIRPEGILWICIGFALTVVPVLLVGMAALRSHKFDYGTICGILSGSMANPMALAYVNDTIEGNSPSVSYATVYPLGMFARVILVQMLLMIAGG
>NC_014033.1|WP_013063598.1|772753_773668_+|glutaminase
MDYGQIIDKVYTACLPFANEGRQADYIPMLAEVDAKQFGLCLLTLDGNVYEQGNTRTRFSLQSISKVFALAMCLSQEADRLWQRMGKEPSGNAFNSLVQLEYEHGIPRNPFINAGAIVMADVLLSTLSRPEEQFLTFVRSLSGSSTVGFNRRVAQSEQSCGYLNAAIANLLKYHGNIRGDITRVLEFYFLMCSVEMSCHELAHAFLPFANHRQPFNYGGVSLTSSQVKRINAIMQTCGFYDEAGEFSYRVGLPGKSGVGGGIAAIHPLHYAVATWSPRLNIKGNSVMGMKALELLTSETEESIF
>NC_014033.1|WP_041385608.1|770366_772409_+|hypothetical-protein
MLEYTYNYKLHIAFQNLMEDYRVDAWSGIHKLFSSYRDVLPWIYRDKRRYKFENVGISCPADVSDFLHQFGKKYKAYISQHAVDFEAQSEKELIETVSILFRNELEKQQLYDADVIDALRAIYPDYTLFARDLLYYPYQVCNIIFVYNEKYALACLDMILNICSKIKETLKARALFHGNYDDFVDAVKWLSYYRDNNNVRLVHFANITPDKDSLLRHAFEETLSRYDNKTQSVIVKGEIDYLEFMCFLKNENELFRLSRVGIERFQQLKKLLADFEPIYHKILFDNTDNVRYNLCKYQFHFLSNDDVEFVSQFYGKHHHYPMFYILCRYFNTTTNNNAKIFASYCGLGDEATLAAARSKFSRERIRQIIGIKSFADQDYKNVMNPQWWQPYNLSFTGVLTPKMSQFKNISRREHLSISFNTYACLANLFQDSRVLHFTTRYTDIGIGKISAYINGNQPFHTCIYDAKYLNFNFFSAFEDFEIMVRKYRKNTDKISLLPFVSNPKYWREGKVISADSVEHFLYVFECIIKDFWGVSVQDHYVQLPANRIDYAEIFYNIIKDNGKGMFVNDIFARYKQLYPRSKYKTPLQIKPYLFKDERLINIGKTTIYSLVEWGVFSGSLFDLVVDVVAQSDSPVRVRDLISQVLERRPSSTKRSVENIIYLCVKDGRLVRVGKALIDIP
>NC_014033.1|WP_013065062.1|769021_770197_+|glycoside-hydrolase
MKIFKTWITAAVLFGGLLLTACTNDDNPSGSSAGSVEEQLRKMTLREKVGQMFYVRPEALDTTIHWSSFEELSPYKLQQINDCMAGVVKNYPIGGMILYAWNIEDENQLSSFISQIRALNGSPLLCIDEEGGRVSRLANHPNFNLPKYESMESIGETGDPANAYECANTIGTYLTRYGFDIDFAPVADVNTNPDNVVIGKRAFSSDPAVAASMVTSYLQGLKDAGITGCIKHFPGHGDTTADTHYGYAKSMKTWDEMMDCEMVTFRAGIAWGCELIMTAHIATPNVTGTDEPATMSPVILKDKLRGELGYRNIIVTDAISMGAITKQYTNAEAAVGCIKAGADIVLDPRNLVEAFDAVIAAVNDGTLSEARINQSVRRILTLKQQIRNRTK
>NC_014033.1|WP_041385617.1|780962_781211_+|hypothetical-protein
MANRNVILLHLLESDTYEFFGSPASLFDKHEANELLIAQTSLNNHFSKMAAQGKELVYRNAYCEIRKGEIYVKPSTRGRKKF
>NC_014033.1|WP_013063702.1|781263_782370_+|HindVP-family-restriction-endonuclease
MAKKDTKEVACFVEGVLPGLFGQKYSSRDYRYEDSWGKNQFNSSFPASLVAYMGSKGVNPIYICTNKKNEVVHKTINTTDLFGVNPLGEDAYYNYEAEYYPYEQFYYAAKKEKIDLVMINRSTEVAASGLEVKLTTLPDNTTKDLEESEYGSEIVVRSPTILFLACSICSCYNSEKGKNRLHSILNTIGSEIKNWSEIRQVLPHYKAICKAILDVSIDLSNKQIPLIIQPIWKTDKKLKDFADDCLDVFVWSNLSVIQMCLRETNADNDISRNQRTIIWLYKMLWDFSLYGSFNYTGIVNELAYNYKTDKAFSISGKLTNPLMRCPELTKPRISKYEIKNIILGDGQKLLSPERRFDAFIVSHPELFK
>NC_014033.1|WP_013064476.1|782366_783713_+|DNA-cytosine-methyltransferase
MKVVDLFCGCGGLSLGFQKAGFNILAAFDNWDDAITVYHANFKHPVIKQDLSNVDQTVEKVKKYKPDMIIGGPPCQDFSSAGKRDENNGRGDLTINYAQVIAALKPDWFVMENVDRITKTEKLVEAKTIFKQCGYGLTYAILNASRCGAPQRRKRFIMIGHLGEEDGFMSNILELRQSDKEMTVADYFGSQLDIQYYYRHPRSYARRGIFSVNEPSPTIRGVNRPMPAGYQLHSNDPVKSLEGIRPLTTLERSMIQTFPKDFRFLGNKTNMEQMIGNAVPVNLARYVGECIMAYLGNNNPVNYEQLREDYPEKIVNNSSVSINPELKVDKEKNVLISLVKNDNVDLFLDGSARIYYTGKKFPSTVALNKLYYFMPYVKQKGIRDIYLIKIARVGSKHEIHPDADENDLRLVFEIEKIGQLFDDYKPVELKIWHTFTDTTIKSVLSNRL
>NC_014033.1|WP_013065588.1|783719_784328_+|hypothetical-protein
MVAKSKQQRLNEEIAYELDKYQVMLEYGRMCLDDDKAIRKKYAWMNYVKNGCLSGMAIDLIMAGATKLISSEFFGVYLPYFLIVFFLVLIMYIFFFFIHRKQIAKLIGAEEKATLKELLDNLRSYLHKLGEWMKEVDCHIEQEKSVLDIIEKELAVAKSQQAKEVNKLSEIYGNLDEKMDDKAHQMAEERLIQYKRFIYDYE
>NC_014033.1|WP_080517223.1|784895_785339_+|HNH-endonuclease
MAHYDITKEGEDVIYEAKRRKGQNYFRFMVLDNYGSRCALTGIDIPELLLASHIIPWSDKKHKSDRLNPCNGICLSALYDKAFDKGLITFKDDLTALFSNKLEANVGKEYFKQYFEPIRNKKLITPRKYLPSPEFLEWHRDCIFSKE
>NC_014033.1|WP_041385619.1|785972_786242_+|hypothetical-protein
MIACLIWVLLYAFIIWMLAAITSWWAVIIMHIGAVIFLLIYKGDAIFRGSNPPENPDDKTCDDESYRAAREERDAYDDYIASIDMDKDR
>NC_014033.1|WP_033151324.1|786439_786859_-|hypothetical-protein
MNKLIVSALLCLASITASAQNTQGPFRAYLINKELDIVMRINFYQQDVTVPGQDLFGQVPGYLSKRFNSFAWVITDAEVKGHKATLQMINDYGSEDLTATLTAKGDSVFILKQESGSALKVPFKGKWQKLPKTIEFRRQ
>NC_014033.1|WP_013064685.1|787000_788713_+|glycogen/starch-synthase
MAKERFTPDFIFESSWEVCNKVGGIYTVLSTRAKTLQQVLKDKIIFIGPDFWKEQESPYFREANSLLAEWQWAAKEQGLKVRVGRWTVPGEPIAILVDFNPYFEKKNEIYGWLWEHYQVDSLHAYGDYDEASMFSYAAALVVESFYKHSLKPEQKVIYHANEWMCGLGLLYLNNKLPQIGTVFTTHATSIGRSIAGNQKPLYDYLFAYNGDQMAGELNMQSKHSIEKQTAHYADCFTTVSDITAKECVELLDKPVDVVLPNGFDNSFVPATAQAFARKRKAARKKMLQVANALLGEELDDDTLLISTSGRYEFRNKGIDVFVEAMNRLLRDRDLKKKVVAFIEVPGWVGEPRKDLQERLATLNIKHETLNIKQATNSEQPSFNTPLEVPMVTHWLHNMSHDNVLSMLKYYDMHNRKDENVKVIFLPCYLDGNDGIVNMTYYDVVLGNDLCIYPSYYEPWGYTPLEAIAFKVPCITTDLAGFGLWANTVFGHDGQLEDGVKVIHRTDYNYSEVADNIKDTVAEFSNMTKKQIETCRKNAEALSEKALWTHFIEYYYEAYDIALRKAQMRVH
>NC_014033.1|WP_013064138.1|788786_791366_+|alpha-glucan-family-phosphorylase
MKIKADYANAPMWKDLTVKSSLPEELKCLDEIAHNMWWVWNYEARDLFRDLDPELYHEVKHNPVMLLERLSFARKEQIVKDKALMKRIKSVYTLFRKYIDVEPDKKRPSVAYFCMEYGIHSALKIYSGGLGMLAGDYVKEASDSNVDMCAVGFLYRFGYFTQSLSMEGQQVANYEAQNFSNLPIERQLDKDGSPMVIDVPYTNYQVHAYVWRVNVGRVKLYLLDTDNEMNSEFDKPITHSLYGGDWENRLKQEILLGIGGMLLLKKLGIKKDIYHCNEGHAALCNLQRLCDYIDEGLTFNQALELVRASGLYTVHTPVPAGHDYFDEGLFGKYMGGYPQKLGISWDEFIGMGRINPNDHSERFCMSTFACNTCQEVNGVSMLHGWVSQKMFAPIWAGYYPEENHVGYVTNGVHFPTWCATEWRKVYAKYFDAKHMSDQSNEEIWHGIYNCPDEEVWATRMALKNKLFDYIKEQFREKWLKNQGDPSRVVSLLEGMNPNALVIGFCRRFATYKRAHLLFTNLERLSKIVNDPEHPVIFLFAGKAHPADGAGQGLIQRIYEISQRDEFLGKIIFLEDYDFLLARRLVSGVDIWMNTPTRPLEASGTSGEKAEMNGVVNLSVKDGWWLEGYREGAGWALTEKRTYQNQGYQDNLDAATIYHLLENEIIPLYYDKDKKTGLSKGWVKVIKNSIAQIAPHYTMKRQLDDYYEKFYNKQAKRFKALSKDNNKLAKELAQWKETVAERWDAIHVVSAEWDYPAAGIETAQKYTIRYVIDEQGLEDAVALEKVNVHINKEGEERIFSIEPLKMVGHEGNNYIFEATLAPQQAGQFKSAIRMYPKHKELPHRQDFCYIKWLELPAHTV
>NC_014033.1|WP_013063625.1|791400_791973_-|DUF4369-domain-containing-protein
MTNKSFIGLAVASFMLCACQSDVYQIKGCATQLKDGDTVTLAFEDPPQKVLGQAIVSGGTFKFAGTTDTTLFCRAYLNRQQLTSCSFFLEPGEITIELNQHPRPSRVSGTQLNNQWQALNDTVQKLGTQLIRLAQLSTRTNAAHRQQLQQQVDSLHRRISDCITQTGQRNRQNVLGRYIIQNYKKPEFRD

Crispr_ID: NC_014033_4

• CRISPR_ID: NC_014033_4
• CRISPR_location: 1568935-1569956
• CRISPR_type: TypeII
• Repeat_type: NA
• Spacer_info: 15 spacers
• Cas_protein_info: cas2,cas9,PrimPol

Consensus repeat of NC_014033_4

Consensus_repeat	Method
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CRISPRCasFinder
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CRT
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	PILER-CR
CGCGTTGTATATCATTCCTTTCCTACATCAAACCACAAC	PILER-CR

spacers of NC_014033_4

>4.1|1568971|30|NC_014033|CRISPRCasFinder,CRT
CGCCGCAATGCTTTCTACTTTGTGCGTGCA
>4.2|1569037|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR
CAGAATCCCAAAAGAGCAAAAAAGTAAAAA
>4.3|1569103|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR
GTGGATGGTGCGCCAGCTGCAAGGGGACGG
>4.4|1569169|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR
CACGTGTCGGCCACCCTTCCACACGCCCTC
>4.5|1569235|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR
ATAACTATAAGAAAGCCCAGAAGGGTGGTA
>4.6|1569301|29|NC_014033|CRISPRCasFinder,CRT,PILER-CR
TCACCACATCACCATTCTCGTCACGCTCA
>4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR
CGCCTTGATGGTGATGCTGTCGTGCAGATA
>4.8|1569432|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR
TGGGTTCTTCCACACCATGCAGAGCGATAT
>4.9|1569498|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR
ACGGGCACCGCGACAAGCAGAGCGGTTGGA
>4.10|1569564|29|NC_014033|CRISPRCasFinder,CRT,PILER-CR
TAAAGGTTAGCAACTCCCTCCATTTTTTT
>4.11|1569629|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR
ATTGATGGTGTTCCACCATTGACTGAGCAA
>4.12|1569695|30|NC_014033|CRISPRCasFinder,CRT
CTACTACAAAACCCTGCAATATCAGTGCGA
>4.13|1569761|30|NC_014033|CRISPRCasFinder,CRT
GATACCGCCACCACTCTCTGACGCATCGTC
>4.14|1569827|29|NC_014033|CRISPRCasFinder,CRT
TGCGTCTGCCAGGTATGCCCACCATGCGC
>4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT
CAGTCCCAGTTGCTCGCGCAGTTGGTCGC
>4.16|1569695|226|NC_014033|PILER-CR
CTACTACAAAACCCTGCAATATCAGTGCGAGTTGTATATCATTCCTTTCCTACATCAAACCACAACGATACCGCCACCACTCTCTGACGCATCGTCGTTGTATATCATTCCTTTCCTACATCAAACCACAACTGCGTCTGCCAGGTATGCCCACCATGCGCGTTGTATATCATTCCTTTCCTACATCAAACCACAACCAGTCCCAGTTGCTCGCGCAGTTGGTCGC
>4.17|1569761|27|NC_014033|PILER-CR
GATACCGCCACCACTCTCTGACGCATC
>4.18|1569827|26|NC_014033|PILER-CR
TGCGTCTGCCAGGTATGCCCACCATG
>4.19|1569892|26|NC_014033|PILER-CR
CAGTCCCAGTTGCTCGCGCAGTTGGT

CRISPR arrays and Neighbor proteins around NC_014033_4

CRISPR arrays

The CRISPR arrays of NC_014033_4

>merge|NC_014033|4|1568935-1569956|CRISPRCasFinder,CRT,PILER-CR,PILER-CR
ACGATTTTTAATCCTTTTCCTACATCAAACCACAACCGCCGCAATGCTTTCTACTTTGTGCGTGCAGTTGTATATCATTCCTTTCCTACATCAAACCACAACCAGAATCCCAAAAGAGCAAAAAAGTAAAAAGTTGTATATCATTCCTTTCCTACATCAAACCACAACGTGGATGGTGCGCCAGCTGCAAGGGGACGGGTTGTATATCATTCCTTTCCTACATCAAACCACAACCACGTGTCGGCCACCCTTCCACACGCCCTCGTTGTATATCATTCCTTTCCTACATCAAACCACAACATAACTATAAGAAAGCCCAGAAGGGTGGTAGTTGTATATCATTCCTTTCCTACATCAAACCACAACTCACCACATCACCATTCTCGTCACGCTCAGTTGTATATCATTCCTTTCCTACATCAAACCACAACCGCCTTGATGGTGATGCTGTCGTGCAGATAGTTGTATATCATTCCTTTCCTACATCAAACCACAACTGGGTTCTTCCACACCATGCAGAGCGATATGTTGTATATCATTCCTTTCCTACATCAAACCACAACACGGGCACCGCGACAAGCAGAGCGGTTGGAGTTGTATATCATTCCTTTCCTACATCAAACCACAACTAAAGGTTAGCAACTCCCTCCATTTTTTTGTTGTATATCATTCCTTTCCTACATCAAACCACAACATTGATGGTGTTCCACCATTGACTGAGCAAGTTGTATATCATTCCTTTCCTACATCAAACCACAACCTACTACAAAACCCTGCAATATCAGTGCGAGTTGTATATCATTCCTTTCCTACATCAAACCACAACGATACCGCCACCACTCTCTGACGCATCGTCGTTGTATATCATTCCTTTCCTACATCAAACCACAACTGCGTCTGCCAGGTATGCCCACCATGCGCGTTGTATATCATTCCTTTCCTACATCAAACCACAACCAGTCCCAGTTGCTCGCGCAGTTGGTCGCGTTGTATATCATTCCTTTCCTACATCAAACCACAAC

>NC_014033|4|4|1568935-1569956|CRISPRCasFinder
ACGATTTTTAATCCTTTTCCTACATCAAACCACAAC	CGCCGCAATGCTTTCTACTTTGTGCGTGCA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CAGAATCCCAAAAGAGCAAAAAAGTAAAAA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	GTGGATGGTGCGCCAGCTGCAAGGGGACGG
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CACGTGTCGGCCACCCTTCCACACGCCCTC
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	ATAACTATAAGAAAGCCCAGAAGGGTGGTA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TCACCACATCACCATTCTCGTCACGCTCA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CGCCTTGATGGTGATGCTGTCGTGCAGATA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TGGGTTCTTCCACACCATGCAGAGCGATAT
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	ACGGGCACCGCGACAAGCAGAGCGGTTGGA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TAAAGGTTAGCAACTCCCTCCATTTTTTT
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	ATTGATGGTGTTCCACCATTGACTGAGCAA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CTACTACAAAACCCTGCAATATCAGTGCGA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	GATACCGCCACCACTCTCTGACGCATCGTC
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TGCGTCTGCCAGGTATGCCCACCATGCGC
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CAGTCCCAGTTGCTCGCGCAGTTGGTCGC
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC

>NC_014033|4|1|1568935-1569956|CRT
ACGATTTTTAATCCTTTTCCTACATCAAACCACAAC	CGCCGCAATGCTTTCTACTTTGTGCGTGCA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CAGAATCCCAAAAGAGCAAAAAAGTAAAAA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	GTGGATGGTGCGCCAGCTGCAAGGGGACGG
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CACGTGTCGGCCACCCTTCCACACGCCCTC
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	ATAACTATAAGAAAGCCCAGAAGGGTGGTA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TCACCACATCACCATTCTCGTCACGCTCA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CGCCTTGATGGTGATGCTGTCGTGCAGATA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TGGGTTCTTCCACACCATGCAGAGCGATAT
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	ACGGGCACCGCGACAAGCAGAGCGGTTGGA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TAAAGGTTAGCAACTCCCTCCATTTTTTT
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	ATTGATGGTGTTCCACCATTGACTGAGCAA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CTACTACAAAACCCTGCAATATCAGTGCGA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	GATACCGCCACCACTCTCTGACGCATCGTC
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TGCGTCTGCCAGGTATGCCCACCATGCGC
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CAGTCCCAGTTGCTCGCGCAGTTGGTCGC
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC

>NC_014033|4|1|1569001-1569956|PILER-CR
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CAGAATCCCAAAAGAGCAAAAAAGTAAAAA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	GTGGATGGTGCGCCAGCTGCAAGGGGACGG
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CACGTGTCGGCCACCCTTCCACACGCCCTC
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	ATAACTATAAGAAAGCCCAGAAGGGTGGTA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TCACCACATCACCATTCTCGTCACGCTCA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CGCCTTGATGGTGATGCTGTCGTGCAGATA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TGGGTTCTTCCACACCATGCAGAGCGATAT
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	ACGGGCACCGCGACAAGCAGAGCGGTTGGA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TAAAGGTTAGCAACTCCCTCCATTTTTTT
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	ATTGATGGTGTTCCACCATTGACTGAGCAA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CTACTACAAAACCCTGCAATATCAGTGCGAGTTGTATATCATTCCTTTCCTACATCAAACCACAACGATACCGCCACCACTCTCTGACGCATCGTCGTTGTATATCATTCCTTTCCTACATCAAACCACAACTGCGTCTGCCAGGTATGCCCACCATGCGCGTTGTATATCATTCCTTTCCTACATCAAACCACAACCAGTCCCAGTTGCTCGCGCAGTTGGTCGC
	GATACCGCCACCACTCTCTGACGCATC
GTCGTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TGCGTCTGCCAGGTATGCCCACCATG
CGCGTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CAGTCCCAGTTGCTCGCGCAGTTGGT
CGCGTTGTATATCATTCCTTTCCTACATCAAACCACAAC

>NC_014033|4|2|1569722-1569956|PILER-CR
	CAGAATCCCAAAAGAGCAAAAAAGTAAAAA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	GTGGATGGTGCGCCAGCTGCAAGGGGACGG
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CACGTGTCGGCCACCCTTCCACACGCCCTC
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	ATAACTATAAGAAAGCCCAGAAGGGTGGTA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TCACCACATCACCATTCTCGTCACGCTCA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CGCCTTGATGGTGATGCTGTCGTGCAGATA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TGGGTTCTTCCACACCATGCAGAGCGATAT
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	ACGGGCACCGCGACAAGCAGAGCGGTTGGA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TAAAGGTTAGCAACTCCCTCCATTTTTTT
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	ATTGATGGTGTTCCACCATTGACTGAGCAA
GTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CTACTACAAAACCCTGCAATATCAGTGCGAGTTGTATATCATTCCTTTCCTACATCAAACCACAACGATACCGCCACCACTCTCTGACGCATCGTCGTTGTATATCATTCCTTTCCTACATCAAACCACAACTGCGTCTGCCAGGTATGCCCACCATGCGCGTTGTATATCATTCCTTTCCTACATCAAACCACAACCAGTCCCAGTTGCTCGCGCAGTTGGTCGC
	GATACCGCCACCACTCTCTGACGCATC
GTCGTTGTATATCATTCCTTTCCTACATCAAACCACAAC	TGCGTCTGCCAGGTATGCCCACCATG
CGCGTTGTATATCATTCCTTTCCTACATCAAACCACAAC	CAGTCCCAGTTGCTCGCGCAGTTGGT
CGCGTTGTATATCATTCCTTTCCTACATCAAACCACAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014033.1|WP_013064270.1|1560020_1561787_+|bifunctional-metallophosphatase/5'-nucleotidase	unknown	unknown	gnl|CDD|223808
NC_014033.1|WP_049769217.1|1582759_1583500_+|polysaccharide-biosynthesis/export-family-protein	unknown	unknown	gnl|CDD|224512
NC_014033.1|WP_013063514.1|1578214_1579576_-|multidrug-transporter	unknown	unknown	gnl|CDD|240548
NC_014033.1|WP_013064200.1|1567279_1568071_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293799
NC_014033.1|WP_013065595.1|1565869_1566400_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|238017
NC_014033.1|WP_013065591.1|1570048_1570357_-|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl|CDD|226043
NC_014033.1|WP_013063748.1|1563333_1564653_-|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|223936
NC_014033.1|WP_013064160.1|1568472_1568850_+|HEPN-domain-containing-protein	unknown	unknown	gnl|CDD|224807
NC_014033.1|WP_013064830.1|1574279_1574597_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl|CDD|226079
NC_014033.1|WP_013063776.1|1576066_1578181_+|hypothetical-protein	PrimPol	pfam08800_PrimPol_CAS-I:CAS-III	gnl|CDD|370131
NC_014033.1|WP_041385860.1|1564762_1565866_+|SPOR-domain-containing-protein	unknown	unknown	gnl|CDD|380132
NC_014033.1|WP_041385863.1|1574604_1574946_+|HigA-family-addiction-module-antidote-protein	unknown	unknown	gnl|CDD|274228
NC_014033.1|WP_013065637.1|1562553_1563333_-|DUF4738-domain-containing-protein	unknown	unknown	gnl|CDD|374200
NC_014033.1|WP_013065371.1|1568145_1568469_+|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|143393
NC_014033.1|WP_013065449.1|1579584_1580859_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|250388
NC_014033.1|WP_041385861.1|1570397_1574015_-|CRISPR-associated-protein-Csn1	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl|CDD|187774
NC_014033.1|WP_013064412.1|1574942_1575341_-|HU-family-DNA-binding-protein	unknown	unknown	gnl|CDD|375718
NC_014033.1|WP_013063434.1|1580866_1581829_-|sulfide/dihydroorotate-dehydrogenase-like-FAD/NAD-binding-protein	unknown	unknown	gnl|CDD|235613
NC_014033.1|WP_013064585.1|1566405_1567278_+|proline-iminopeptidase-family-hydrolase	unknown	unknown	gnl|CDD|188121
NC_014033.1|WP_013063651.1|1561783_1562557_+|NAD(+)-diphosphatase	unknown	unknown	gnl|CDD|234699

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_014033.1|WP_013065591.1|1570048_1570357_-|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	1e-30	101.1	0.1
NC_014033.1|WP_013063776.1|1576066_1578181_+|hypothetical-protein	PrimPol	pfam08800_PrimPol_CAS-I:CAS-III	9.2e-29	94.8	0.0
NC_014033.1|WP_041385861.1|1570397_1574015_-|CRISPR-associated-protein-Csn1	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	3.5e-66	218.9	31.2

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014033.1|WP_013064270.1|1560020_1561787_+|bifunctional-metallophosphatase/5'-nucleotidase	gnl|CDD|223808	COG0737, UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism].	4.42474e-75
NC_014033.1|WP_049769217.1|1582759_1583500_+|polysaccharide-biosynthesis/export-family-protein	gnl|CDD|224512	COG1596, Wza, Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis].	4.15156e-15
NC_014033.1|WP_013063514.1|1578214_1579576_-|multidrug-transporter	gnl|CDD|240548	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.	1.91243e-86
NC_014033.1|WP_013064200.1|1567279_1568071_+|MBL-fold-metallo-hydrolase	gnl|CDD|293799	cd07713, DHPS-like_MBL-fold, Methanocaldococcus jannaschii dihydropteroate synthase, Thermoanaerobacter tengcongensis Tflp, and related proteins; MBL-fold metallo hydrolase domain. This subgroup includes Methanocaldococcus jannaschii 7,8-dihydropterin-6-methyl-4-(beta-D-ribofuranosyl)-aminobenzene-5'-phosphate synthase (EC 2.5.1.15), a folate biosynthetic enzyme also known as dihydropteroate synthase and 7,8 dihydropteroate synthase. Thermoanaerobacter tengcongensis Tflp is a ferredoxin-like member. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.12252e-88
NC_014033.1|WP_013065595.1|1565869_1566400_+|FHA-domain-containing-protein	gnl|CDD|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	1.26704e-07
NC_014033.1|WP_013065591.1|1570048_1570357_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	3.38609e-26
NC_014033.1|WP_013063748.1|1563333_1564653_-|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl|CDD|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NC_014033.1|WP_013064160.1|1568472_1568850_+|HEPN-domain-containing-protein	gnl|CDD|224807	COG1895, COG1895, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN [Function unknown].	1.81548e-16
NC_014033.1|WP_013064830.1|1574279_1574597_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl|CDD|226079	COG3549, HigB, Plasmid maintenance system killer protein [General function prediction only].	9.20175e-15
NC_014033.1|WP_013063776.1|1576066_1578181_+|hypothetical-protein	gnl|CDD|370131	pfam08800, VirE_N, VirE N-terminal domain. This presumed domain is found at the N-terminus of VirE proteins.	1.32086e-42
NC_014033.1|WP_041385860.1|1564762_1565866_+|SPOR-domain-containing-protein	gnl|CDD|380132	pfam18174, HU-CCDC81_bac_1, CCDC81-like prokaryotic HU domain 1. First of two HU domains found in bacterial proteins typically fused to a C-terminal transmembrane helix and an extracellular peptidoglycan-binding domain. The HU domains in many of these proteins are predicted to function in tethering the nucleoid to the cell envelope.	2.00379e-35
NC_014033.1|WP_041385863.1|1574604_1574946_+|HigA-family-addiction-module-antidote-protein	gnl|CDD|274228	TIGR02607, Virulence-associated_protein_I, addiction module antidote protein, HigA family. Members of this family form a distinct clade within the larger family HTH_3 of helix-turn-helix proteins, described by pfam01381. Members of this clade are strictly bacterial and nearly always shorter than 110 amino acids. This family includes the characterized member HigA, without which the killer protein HigB cannot be cloned. The hig (host inhibition of growth) system is noted to be unusual in that killer protein is uncoded by the upstream member of the gene pair. [Regulatory functions, DNA interactions, Regulatory functions, Protein interactions, Mobile and extrachromosomal element functions, Other].	6.87292e-23
NC_014033.1|WP_013065637.1|1562553_1563333_-|DUF4738-domain-containing-protein	gnl|CDD|374200	pfam15889, DUF4738, Domain of unknown function (DUF4738). Family of uncharacterized proteins found in CFB group of bacteria, mostly from Bacteroides and Prevotella genera present in human gut and oral cavity, respectively. JCSG target SP13584B, the experimentally determined structure consists of two WD40-like beta sheet repeats forming a beta sandwich.	3.38977e-62
NC_014033.1|WP_013065371.1|1568145_1568469_+|nucleotidyltransferase-domain-containing-protein	gnl|CDD|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	5.09115e-14
NC_014033.1|WP_013065449.1|1579584_1580859_-|FAD-dependent-oxidoreductase	gnl|CDD|250388	pfam01134, GIDA, Glucose inhibited division protein A.	6.04733e-35
NC_014033.1|WP_041385861.1|1570397_1574015_-|CRISPR-associated-protein-Csn1	gnl|CDD|187774	cd09643, Csn1, CRISPR/Cas system-associated protein Cas9. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II.	1.42735e-48
NC_014033.1|WP_013064412.1|1574942_1575341_-|HU-family-DNA-binding-protein	gnl|CDD|375718	pfam18291, HU-HIG, HU domain fused to wHTH, Ig, or Glycine-rich motif. Rapidly-diverging family of HU domains predominantly observed in the bacteroidetes lineage with a predicted role in recognition and possible interception of the DNA of parasitic elements, a counter-conflict strategy preventing incorporation of these elements into the host genome.	1.47695e-12
NC_014033.1|WP_013063434.1|1580866_1581829_-|sulfide/dihydroorotate-dehydrogenase-like-FAD/NAD-binding-protein	gnl|CDD|235613	PRK05802, PRK05802, sulfide/dihydroorotate dehydrogenase-like FAD/NAD-binding protein.	6.9336e-157
NC_014033.1|WP_013064585.1|1566405_1567278_+|proline-iminopeptidase-family-hydrolase	gnl|CDD|188121	TIGR01250, Proline_iminopeptidase, proline-specific peptidase, Bacillus coagulans-type subfamily. This model describes a subfamily of the alpha/beta fold family of hydrolases. Characterized members include prolinases (Pro-Xaa dipeptidase, EC 3.4.13.8), prolyl aminopeptidases (EC 3.4.11.5), and a leucyl aminopeptidase.	4.57201e-97
NC_014033.1|WP_013063651.1|1561783_1562557_+|NAD(+)-diphosphatase	gnl|CDD|234699	PRK00241, nudC, NAD(+) diphosphatase.	7.41675e-81

Protein sequences

>NC_014033.1|WP_013064160.1|1568472_1568850_+|HEPN-domain-containing-protein
MDKELLIKLQKDKSHKMLADADEMVIQKRWDIAANRYYYACYHMLQALFISRGVSAKSHDGSLTHLGQDFILSGEVDKKFGRFFSRMVQLRHKADYNSIAEVTEDEVLEMQPLSKEFVEQVEAII
>NC_014033.1|WP_013065371.1|1568145_1568469_+|nucleotidyltransferase-domain-containing-protein
MTDKNRKVLDQIKAVARESAPKGSLVILFGSRARGEAKRGSDWDILIVLPKNRLEQSDYDDVSFPFVELGWKLNEQINPVMYTKAEWDASSITPFYDNVVRDGINLI
>NC_014033.1|WP_013064200.1|1567279_1568071_+|MBL-fold-metallo-hydrolase
MTWTVISDNRSNNPELETEHGLSILLQTERHKILLDTGASDVFMRNAEQMGINLSDVDYVFISHGHSDHAGGLRYLLEHNQQARIIVSPDAMSGKFFSKRGNLHSITTEWPEISNDRLILIDHACEIADGLRVIAHIPQTHPMPKGNQNLFIQDGYGDYIHDDFRHELALYSDGLLFTGCAHNGLENILSACPWPVHTVVGGFHLLDGLQSDEEITDLAQRLTTNYPNTHFYTSHCTGDHVFEVMKTIMPTHIHPFTCGTTKE
>NC_014033.1|WP_013064585.1|1566405_1567278_+|proline-iminopeptidase-family-hydrolase
MITEGYMPFMGYQTYYRIVGEASEKTPLLLLHGGPGSTHNYFEVLDCIAETGRQVISYDQIGCGNSYLDGHPELWTQKTWIDELIAIREYLQLDAVHILGQSWGAMQAIAYVIDHQPQGIKSLILSSGHASSSLWASEQHRLIKYLSDEDQEAIRHAEATGKWDDEAYLQANNHYFEQFVISVDEHSPECLRRPKRAGAEAYLYGWGPNEYQPLGSLKDFEYTDKLDQISQPTLICSGTRDICTPVVAASLYEHIPHSQWHLFRHSRHTCFIDAHQEYCQVLTKWLEEND
>NC_014033.1|WP_013065595.1|1565869_1566400_+|FHA-domain-containing-protein
MKRVRCPKCDQYITFDETKYEAGQSLVFKCPDCGKEFGIRIGVSKLRERQKDENPDEQANEQGCGSIVVIENVFHYKQVIPLRMGDNIIGRYQKGNPANTAFETVDPSVDLNHCTITVSRDKKGGLRYTLKDNNSNTGTFIDNVELTPKERRVISDGTLFTLGATSIILRTSNDEE
>NC_014033.1|WP_041385860.1|1564762_1565866_+|SPOR-domain-containing-protein
MIELERHIEILLLDNDCVIVPGLGGFMAHHVEARYEEDEQAFLPPLRTLGFNPQLKINDSLLAQSYIEAYDISYPEALQRIEDEVNELTQILQNEGRYELNNIGIIELNEDGNYVFTPCEAGILTPSLYGLNSFEMKLIKTVSSESVEETPEAKVVEMKPEPKPESEVNSVLQQNLVDINDDDTDVVRIKFSWIRNAVAVAAILLAVFFVAMPTGKTELMKSTINSLNNQILFGMMTSKDTNTSAIDFKRKDAQKPAAVKTAEAILDTIKPAKPAEATKPVAIKPDSTREGYCIVLASHVNKQNAEIFINNLAERGYKGAEIYVHNNITRIVYGHYENQADAYTQLQKIAKEKDLAESWVYKYNEKK
>NC_014033.1|WP_013063748.1|1563333_1564653_-|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MNIAIVGTGYVGLVSGTCFADTGANVTCVDVDENKIERLKNGEIPIYEPGLDELVKKNVAAGRLKFTTDLASVLDDVEIVFSAVGTPPDEDGSADLKYVLQVAKTIGQNLKKYVVVVTKSTVPVGTAKKVRKAIEDELAKRGVDVEFDVASNPEFLKEGNAIKDFMSPDRVVVGVESEKAKKTLTKLYKPFLINNFRVIFMDIPSAEMTKYAANSMLATRISFMNDIANLCERVGADVNMVRAGIGSDTRIGRKFLYAGCGYGGSCFPKDVKALIKTADQNGYSMEVLKAVERVNEKQKSVLFEKLVKAFGSVEALKGNTIAMWGLSFKPETDDMRESTALVMIAKLLEAGCNVRVYDPIAMDECKRRIGETVTYCRDMYDVVLDADALLLLTEWKEFRLPGWGVIKKAMKRPLVIDGRNIFDSEELDENGFEYHCIGK
>NC_014033.1|WP_013065637.1|1562553_1563333_-|DUF4738-domain-containing-protein
MKKILTISMLMVVLVACNQNNSSTLPDDKAAKEMLQGVWVDEESGDVSFRVSGDTLYFADATSMPTYFRIYKDSLYLASGTSYSIVKHTEHLFWFNNQNGDLLKLQKSDDADDADIETAAPSVLTYTHQVKIDSVAAYNGNRYHWYIAINPTKYKVTKRTFNEDGLEVENVYYDNIMHISVFQGARQIYSSDFHKQQYQGLVPAEFLNDAILANMAFSHIDASGLHFNATLCIPDGATCYMVESTISYTGVLSMQLVEY
>NC_014033.1|WP_013063651.1|1561783_1562557_+|NAD(+)-diphosphatase
MKQHYFVFCKEDLLLEKTADGGYTIPFQEEPPTEVKPWTNVMTVTPLDGVEVKTYKIDSPVCDDPRYEMCGLRQSFYKLDKALYQKAGKCQELLYWDANTKYCGVCGAPMRMDTDISKKCTECGKEIWPQLATAVIVLIHKGDEVLLVRAKNFRTDFYGLVAGFVETGETLEEAVAREAFEETGVKITNIRYFGSQPWPYPCGLMVGFNADYVSGDIHLQASEIAKGGWFRKDNLPTIPEKLSIARMLLDAWLAEKD
>NC_014033.1|WP_013064270.1|1560020_1561787_+|bifunctional-metallophosphatase/5'-nucleotidase
MKKLAIILISTLLSVAPIEAKDNKTVKIKVIETSDVHGHFFPYDFMEQTPIKGTLSRANTYIKKQRKKYGEDHFLLIDNGDILQGQPCVYWSNYVMPEDENIAASVINYMKYDAETVGNHDIEPGHKVYDKWIREVRCPLLGANIVKEEYKNAEARPEHIYTGLKPYSVHYKDGVKIVVIGMITPAIPNWLNKSIWKGLEFEEMTACAKKWIKYVKENEKPDLIFGLFHSGLNGGIKTAEYEEDATESVAREVPGFDIIFFGHDHQVHNMLITNKAGEKVLCVDPSCYVNNVAEAEITLTYKDGKLSKKSIIGNIVNVRDEKIDKQMITYFQPTIDKVKEYVSQKIGYFKNPIYTRESFFGNSAFTDLIHNLQMSISKADISFNAPLAFDTTIDAGEVTQADMFKLYRFENLLFVLKMTGEEIRKHLEFSYDMWCNTMTSPNDHALRLNDDSKEDQQRTGFQYYTFNFDSACGIDYEVDLTKPDGQKVRILRMSNGEPFDEKKWYKVVMNSYRANGGGELLTRGAGIPQDSLESRVLFHTELDQRHYLTEEIKRLGTIDPQKNNNWKFVPEAWVKPALERDRKQLFEK
>NC_014033.1|WP_013065591.1|1570048_1570357_-|CRISPR-associated-endonuclease-Cas2
MWLFVFFDLPVVTKKERKIAATFRKNLMKDGFVMLQFSVYIRHCASKESQAVHIKRVKSIVPETGMVSILSVTDKQYGDIVNFWGKEKSKKVPTDPLQLEFF
>NC_014033.1|WP_041385861.1|1570397_1574015_-|CRISPR-associated-protein-Csn1
MMERILGIDTGTNSLGWAIVDKDENQYHLVAKGTNIFSEGVKIEKGIESSKAAERTEHRSVRKHYWRRKIRKIRLLTILSDNDLCPRLKHEQLRQWRLKKVYPTDDTFMEWQRTEDKAQVNPYKFRYICLTQKLDLSDITQRFILGRALYHLNQRRGFLSNRKEATKESEGTVKEGISSLSKDMKDSGCEYLGEYFYQLYQQGKKIRNHYTARKEHYLKEFKAICSKQELDDALIEKLEKAIFDQRPLKSQKGQVGTCTFEKGKSRCPSSHPLYEDFRMYSFINNIKVQVDTLYDKGERSLTDEEKQLIIPLFKRKSKRTFPFEDIAKKIAGKNNYCYIKSNEEKAYKFNYQMDTQVSGSPVNAQLEEIFGEDWLSSVCEVYTLANNKSRFQIMNDVWHVLFFYDDEDKLKEFAKDRLQLDDELAEKFSKISIPNDYAALSLKAIRKIMPYLRDYGLIYSEAVFLANLVDVLPQHVWGIKEMREAAIENVIDVMHSYDKNNIDGITLEGCVKTFLKERYQVSDDNLKKLYHPSMLDPYPRQRPNDEGVFQLGSPRISSVKNPMAMHSLFRLRKVVNLMLKKGYITPDTKVHIEFSRDLNDANKRWAIQTWQRENEKERERCRKEIEKYIASPSDTDILKYQLWEEQNHKCLYTGDEIRITDFLGDNPKYDIEHTIPRSAGGDSTKMNLTLCSSRFNRDEKKTKLPAELVNHDEILERISNWKEKYEDIDKQIRKISTKGATSKEDKDSKIRRRHYLILQRDYWRGKYQRFTMTEVPEGFSRRQGTDISVISRYARMYLKSVFKQVYIVKGIATSDFRKMWGIQDEYAKKERVNHVHHCIDAITIACIGKAEYDKLADYRHQYDDYLFQGKTKPTFDKPWPSFVIDIKHIQDELLIAHYAKDNLEKFTKKNLRGKDGRIIRDKFGNKLQMKGDTSRNSLHNDKFYGAINHEGEIKYVYRTNIEALDAKSIGNIVDPTVRSIIESAIAIHGSLKAAINKGIWMNEEKHIPIKKVRVFRNDVKKPIELKDQRDLSDKDYKQHYYVTNDGNYMMLIFSKLNNKGREIRQHVVINSLEATEVIKSHKRSQVGKVVWESYYSKEGFDLIYKLKSGTMILLYENNRDEVWDLDIRNLQKRLYIITKMKYDGRIYMMHHQEAREKKDLEEKSGSFKINEDYRPLIVNSYNQFNALVQDLDFEINDLGEIRRLI
>NC_014033.1|WP_013064830.1|1574279_1574597_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MVVTFNEDYLEKLYTKGETGVKKLRFQPQIVRGYQKGIKFLIQAKRKEDLFPFKSLHFEALHGDKEGRFSIRANDQYRIEFTLEETGDEPVVTICNIMELSNHYK
>NC_014033.1|WP_041385863.1|1574604_1574946_+|HigA-family-addiction-module-antidote-protein
MAKNNFSKEKIANNMTSSMLIHPGEMIKDEIMARGLTQKDLAQQMGVSYTVFNEILNGKRPVTTEYALLLEAALGTDANIWLGLQADYNMQKMKQDKSFMSRLEKIRKIAAIF
>NC_014033.1|WP_013064412.1|1574942_1575341_-|HU-family-DNA-binding-protein
MKYRLKKETKPTLPTFGKYKAVAVHYHTVESRQLIKEVAQRMGTHTSNVLAVMTSVAEVVNNHLREGDRVRLEDWGMMKLEIESEKVDNLKDFKAKKHIRGVRLHFLPQSYEGHQELYEGITFEKDKLYTED
>NC_014033.1|WP_013063776.1|1576066_1578181_+|hypothetical-protein
MKITLLKKEGRKEVINRVELAEMASAIKNGMIEKTVRQTREVYHLMNPHRLSDGQITTQIEGGIKLPRICFVADYQNRKGDWRMLAYNGLVVLEVNDLQTYEEAVEIRELAKKLPETLMCFLGGSGRSVKIVCRGELFEGGLPKGEKDIRQFHLNLYNTARQAYQNQFGFDIQFLEPRLDRTVYMSADPEMGYNADARPFYADTNEHTLPQPVTISRDEDHLMPGRTVTRTYHLNWTFIVETIMGHYFDLPDENKEAELLMQIAARCLDEGIPQAHAKGLTMLHPVLNRDKMLVEKIFQTVYSVTEQEDYREKHKIKPLKSVPEDTIQAMKTEIFLNSNFDMRKNLLTGVAEYREKFSNDQRFKPLTEEVRNDMTLRATELGLKAWDRNVNRFIDSTRIEQFDPINTWLDQLPKWDGHDYIAELAARVPTSQPHWPKYLKYWLMGMVGQWRESDKQLTGNALTPLLIGRQGCGKTRFCKIILPPELRDYYNDKLNFKNEFDLNIALTSFALINIDEFDKTTSSQQIVLKYLLSSSDVKFRPPYGKTIKLYRRYTSFIGTTNQMKPLVDPTGSRRFVCVGVEGNIDFSDTLNHEQLFAQALYLFNKGERFWLNDDEIKQLMAENEPFQKLNDLVEMIGETFRRPKETEQGKWWSLGDISQVLATRYANFDPETPFQKIGNALNDVQFNFKSKRKTNHMEYWLIEK
>NC_014033.1|WP_013063514.1|1578214_1579576_-|multidrug-transporter
MRSYKVDIEVFERMPVARAVLAQSIPAIVAQLIVLLYNWADTFFLARLNKPELVAAATIVLPLYLMLTAIGNLPGVGGGSQFANHLGKHDYTGAQRVASITFWMGMILALVCCLSFPLYSDILLSLIGANERTLAPAKEYAFWVITIGGIPVIMNLVLANLVRAEGMALQASIGISAGGILNCLLDPLLMLPSMGNMGIVGAGIATAVSNMVSVLWLLVVIWRRRKTGVLTFAPQLLRYTRHYIGSISKVGFPSSIQYMLTVVAVAALTHFVAQYNTEATAALGIVKRLDYLPLYFTIGLSQGILPLLAYNHSSGNVVRRNHVFKCGCIISFGFAMLCFAVFEIWAYQLAMLFTQESLTVSYIVPFLRIQVVAMPFMAVCYPSITLFQAMERSREALICSILRKGVVDIPLLIVMNALWPLFGCMWVQPIVDFTSMLVAFYFSSQIRAQIHDY
>NC_014033.1|WP_013065449.1|1579584_1580859_-|FAD-dependent-oxidoreductase
MRVIIIGGGWAGTAAAIAARKAGAEVCLIEKTDMLLGCGNAGGIMRNNGRFTAAEEMIALGGGELFQLIDRIALHRNVEFPGHHHATLYPVNTIEAHVRRLVLEMGIDVHCSTHICDVVCDNNQLKGVYADSGDLFEGDVFIETTGSAGPMGNCLKYGNGCCMCVLRCPAFGPRISITERCGGQDYQGERQPDMFGVFSGSCKVSKESLSAALQEELNSKGVALIPLPKEEINYDKLKIKACKQYAIKDFSENMILLDTGDAKLMTSYYPVEKLRRLPGMENARYVDPCAGSKGNSIRYLSVAYRSNAMTVDGISNLLCAGEKSGLFIGHTEAITTGTLAGHNAARLAAAKPLLTLPQTLAVGDLIAAANSAIKERHDTMERFTFSGGNYFNRMKEKQLYTTDIEAIRLRVEQAGLLGVYNEHV
>NC_014033.1|WP_013063434.1|1580866_1581829_-|sulfide/dihydroorotate-dehydrogenase-like-FAD/NAD-binding-protein
MIINGLCADYGSRFCPCILAVTGGCVVCSQVNGKAFCDCKASGGICIKQELLRNGGKANPGRLTYECEVISVIHYDGLVFLRVKVPISLEREVKRPGGFVFVRRKDAASWYDVPISVQFEEMMVGSIGMTLLFRGVKTNQFKDLAEGDTLLLRGPFNNGLLGLQHLEAQQSSRCLILTKGIGLLPSVSAVRYLQSRHNETELYVDEGNFSPSILKFQLDLFELPFKPLTLLDDDGELSTPAKHVIRRFVADGGSLIHVGASEYVIHQVAAYLHYIGNRHVKLSACNNARMCCGEGVCGACTETTADKRVIHHCKEQVKIK
>NC_014033.1|WP_049769217.1|1582759_1583500_+|polysaccharide-biosynthesis/export-family-protein
MASCSTPRNFNYLQDLQNGQQTDITIDGTIKLQPNDQLTVIVKSKDPLMSNLFNKSMATQITQGNAAGNPYIAPYTVSPQGTIDFPVIGEILVGGLTRYEAEQTIKRELQKEQLKDANVTVELQNMTYTVTGEVKEPGVYKIEKDQITLLEALGKAGDLSQYGKRDSVMVIRTDGGKRKTYVLSLTDGQKLLNSEAFNIHQNDIIYVKANNVRARQSTANGNETRNASFWLSIVSVLTTVAVFLFK

Crispr_ID: NC_014033_5

• CRISPR_ID: NC_014033_5
• CRISPR_location: 1575653-1575741
• CRISPR_type: TypeII
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: cas9,cas2,PrimPol

Consensus repeat of NC_014033_5

Consensus_repeat	Method
AAATTCTCTAGAGAATTTTGCAGC	CRISPRCasFinder

spacers of NC_014033_5

>5.1|1575677|41|NC_014033|CRISPRCasFinder
TACCCAGGTACTCAGTAATGTTTAGTAAGGCACTTAGCCGA

CRISPR arrays and Neighbor proteins around NC_014033_5

CRISPR arrays

The CRISPR arrays of NC_014033_5

>merge|NC_014033|5|1575653-1575741|CRISPRCasFinder
AAATTCTCTAGAGAATTTTGCAGCTACCCAGGTACTCAGTAATGTTTAGTAAGGCACTTAGCCGAAAATTCTCTAGAGAATTTCGCAGC

>NC_014033|5|5|1575653-1575741|CRISPRCasFinder
AAATTCTCTAGAGAATTTTGCAGC	TACCCAGGTACTCAGTAATGTTTAGTAAGGCACTTAGCCGA
AAATTCTCTAGAGAATTTCGCAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014033.1|WP_013064160.1|1568472_1568850_+|HEPN-domain-containing-protein	unknown	unknown	gnl|CDD|224807
NC_014033.1|WP_013064213.1|1583510_1585064_+|chain-length-determinant-family-protein	unknown	unknown	gnl|CDD|225747
NC_014033.1|WP_049769217.1|1582759_1583500_+|polysaccharide-biosynthesis/export-family-protein	unknown	unknown	gnl|CDD|224512
NC_014033.1|WP_013063514.1|1578214_1579576_-|multidrug-transporter	unknown	unknown	gnl|CDD|240548
NC_014033.1|WP_013064479.1|1586351_1587482_+|hypothetical-protein	unknown	unknown	gnl|CDD|224287
NC_014033.1|WP_013064200.1|1567279_1568071_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293799
NC_014033.1|WP_013065595.1|1565869_1566400_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|238017
NC_014033.1|WP_013065591.1|1570048_1570357_-|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl|CDD|226043
NC_014033.1|WP_013063776.1|1576066_1578181_+|hypothetical-protein	PrimPol	pfam08800_PrimPol_CAS-I:CAS-III	gnl|CDD|370131
NC_014033.1|WP_013064830.1|1574279_1574597_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl|CDD|226079
NC_014033.1|WP_041385863.1|1574604_1574946_+|HigA-family-addiction-module-antidote-protein	unknown	unknown	gnl|CDD|274228
NC_014033.1|WP_013064412.1|1574942_1575341_-|HU-family-DNA-binding-protein	unknown	unknown	gnl|CDD|375718
NC_014033.1|WP_013065371.1|1568145_1568469_+|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|143393
NC_014033.1|WP_013065449.1|1579584_1580859_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|250388
NC_014033.1|WP_041385861.1|1570397_1574015_-|CRISPR-associated-protein-Csn1	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl|CDD|187774
NC_014033.1|WP_013063247.1|1588202_1589072_+|alpha-1,2-fucosyltransferase	unknown	unknown	gnl|CDD|211387
NC_014033.1|WP_013064226.1|1585063_1586365_+|oligosaccharide-flippase-family-protein	unknown	unknown	gnl|CDD|240534
NC_014033.1|WP_013063434.1|1580866_1581829_-|sulfide/dihydroorotate-dehydrogenase-like-FAD/NAD-binding-protein	unknown	unknown	gnl|CDD|235613
NC_014033.1|WP_013064585.1|1566405_1567278_+|proline-iminopeptidase-family-hydrolase	unknown	unknown	gnl|CDD|188121
NC_014033.1|WP_013065078.1|1587447_1588206_+|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|366154

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_014033.1|WP_013065591.1|1570048_1570357_-|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	1e-30	101.1	0.1
NC_014033.1|WP_013063776.1|1576066_1578181_+|hypothetical-protein	PrimPol	pfam08800_PrimPol_CAS-I:CAS-III	9.2e-29	94.8	0.0
NC_014033.1|WP_041385861.1|1570397_1574015_-|CRISPR-associated-protein-Csn1	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	3.5e-66	218.9	31.2

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014033.1|WP_013064160.1|1568472_1568850_+|HEPN-domain-containing-protein	gnl|CDD|224807	COG1895, COG1895, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN [Function unknown].	1.81548e-16
NC_014033.1|WP_013064213.1|1583510_1585064_+|chain-length-determinant-family-protein	gnl|CDD|225747	COG3206, GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane].	3.05007e-18
NC_014033.1|WP_049769217.1|1582759_1583500_+|polysaccharide-biosynthesis/export-family-protein	gnl|CDD|224512	COG1596, Wza, Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis].	4.15156e-15
NC_014033.1|WP_013063514.1|1578214_1579576_-|multidrug-transporter	gnl|CDD|240548	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.	1.91243e-86
NC_014033.1|WP_013064479.1|1586351_1587482_+|hypothetical-protein	gnl|CDD|224287	COG1368, MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane].	0.008303
NC_014033.1|WP_013064200.1|1567279_1568071_+|MBL-fold-metallo-hydrolase	gnl|CDD|293799	cd07713, DHPS-like_MBL-fold, Methanocaldococcus jannaschii dihydropteroate synthase, Thermoanaerobacter tengcongensis Tflp, and related proteins; MBL-fold metallo hydrolase domain. This subgroup includes Methanocaldococcus jannaschii 7,8-dihydropterin-6-methyl-4-(beta-D-ribofuranosyl)-aminobenzene-5'-phosphate synthase (EC 2.5.1.15), a folate biosynthetic enzyme also known as dihydropteroate synthase and 7,8 dihydropteroate synthase. Thermoanaerobacter tengcongensis Tflp is a ferredoxin-like member. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.12252e-88
NC_014033.1|WP_013065595.1|1565869_1566400_+|FHA-domain-containing-protein	gnl|CDD|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	1.26704e-07
NC_014033.1|WP_013065591.1|1570048_1570357_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	3.38609e-26
NC_014033.1|WP_013063776.1|1576066_1578181_+|hypothetical-protein	gnl|CDD|370131	pfam08800, VirE_N, VirE N-terminal domain. This presumed domain is found at the N-terminus of VirE proteins.	1.32086e-42
NC_014033.1|WP_013064830.1|1574279_1574597_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl|CDD|226079	COG3549, HigB, Plasmid maintenance system killer protein [General function prediction only].	9.20175e-15
NC_014033.1|WP_041385863.1|1574604_1574946_+|HigA-family-addiction-module-antidote-protein	gnl|CDD|274228	TIGR02607, Virulence-associated_protein_I, addiction module antidote protein, HigA family. Members of this family form a distinct clade within the larger family HTH_3 of helix-turn-helix proteins, described by pfam01381. Members of this clade are strictly bacterial and nearly always shorter than 110 amino acids. This family includes the characterized member HigA, without which the killer protein HigB cannot be cloned. The hig (host inhibition of growth) system is noted to be unusual in that killer protein is uncoded by the upstream member of the gene pair. [Regulatory functions, DNA interactions, Regulatory functions, Protein interactions, Mobile and extrachromosomal element functions, Other].	6.87292e-23
NC_014033.1|WP_013064412.1|1574942_1575341_-|HU-family-DNA-binding-protein	gnl|CDD|375718	pfam18291, HU-HIG, HU domain fused to wHTH, Ig, or Glycine-rich motif. Rapidly-diverging family of HU domains predominantly observed in the bacteroidetes lineage with a predicted role in recognition and possible interception of the DNA of parasitic elements, a counter-conflict strategy preventing incorporation of these elements into the host genome.	1.47695e-12
NC_014033.1|WP_013065371.1|1568145_1568469_+|nucleotidyltransferase-domain-containing-protein	gnl|CDD|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	5.09115e-14
NC_014033.1|WP_013065449.1|1579584_1580859_-|FAD-dependent-oxidoreductase	gnl|CDD|250388	pfam01134, GIDA, Glucose inhibited division protein A.	6.04733e-35
NC_014033.1|WP_041385861.1|1570397_1574015_-|CRISPR-associated-protein-Csn1	gnl|CDD|187774	cd09643, Csn1, CRISPR/Cas system-associated protein Cas9. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II.	1.42735e-48
NC_014033.1|WP_013063247.1|1588202_1589072_+|alpha-1,2-fucosyltransferase	gnl|CDD|211387	cd11301, Fut1_Fut2_like, Alpha-1,2-fucosyltransferase. Alpha-1,2-fucosyltransferases (Fut1, Fut2) catalyze the transfer of alpha-L-fucose to the terminal beta-D-galactose residue of glycoconjugates via an alpha-1,2-linkage, generating carbohydrate structures that exhibit H-antigenicity for blood-group carbohydrates. These structures also act as ligands for morphogenesis, the adhesion of microbes, and metastasizing cancer cells. Fut1 is responsible for producing the H antigen on red blood cells. Fut2 is expressed in epithelia of secretory tissues, and individuals termed "secretors" have at least one functional copy of the gene; they secrete H antigen which is further processed into A and/or B antigens depending on the ABO genotype. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.	2.88573e-69
NC_014033.1|WP_013064226.1|1585063_1586365_+|oligosaccharide-flippase-family-protein	gnl|CDD|240534	cd13129, MATE_epsE_like, Multidrug and toxic compound extrusion family and similar proteins. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins, including Ralstonia solanaceraum GMI1000 epsE, which may be involved in exporting exopolysaccharide EPS I, a virulence factor. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.97131e-68
NC_014033.1|WP_013063434.1|1580866_1581829_-|sulfide/dihydroorotate-dehydrogenase-like-FAD/NAD-binding-protein	gnl|CDD|235613	PRK05802, PRK05802, sulfide/dihydroorotate dehydrogenase-like FAD/NAD-binding protein.	6.9336e-157
NC_014033.1|WP_013064585.1|1566405_1567278_+|proline-iminopeptidase-family-hydrolase	gnl|CDD|188121	TIGR01250, Proline_iminopeptidase, proline-specific peptidase, Bacillus coagulans-type subfamily. This model describes a subfamily of the alpha/beta fold family of hydrolases. Characterized members include prolinases (Pro-Xaa dipeptidase, EC 3.4.13.8), prolyl aminopeptidases (EC 3.4.11.5), and a leucyl aminopeptidase.	4.57201e-97
NC_014033.1|WP_013065078.1|1587447_1588206_+|glycosyltransferase-family-2-protein	gnl|CDD|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	4.12661e-20

Protein sequences

>NC_014033.1|WP_013064412.1|1574942_1575341_-|HU-family-DNA-binding-protein
MKYRLKKETKPTLPTFGKYKAVAVHYHTVESRQLIKEVAQRMGTHTSNVLAVMTSVAEVVNNHLREGDRVRLEDWGMMKLEIESEKVDNLKDFKAKKHIRGVRLHFLPQSYEGHQELYEGITFEKDKLYTED
>NC_014033.1|WP_041385863.1|1574604_1574946_+|HigA-family-addiction-module-antidote-protein
MAKNNFSKEKIANNMTSSMLIHPGEMIKDEIMARGLTQKDLAQQMGVSYTVFNEILNGKRPVTTEYALLLEAALGTDANIWLGLQADYNMQKMKQDKSFMSRLEKIRKIAAIF
>NC_014033.1|WP_013064830.1|1574279_1574597_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MVVTFNEDYLEKLYTKGETGVKKLRFQPQIVRGYQKGIKFLIQAKRKEDLFPFKSLHFEALHGDKEGRFSIRANDQYRIEFTLEETGDEPVVTICNIMELSNHYK
>NC_014033.1|WP_041385861.1|1570397_1574015_-|CRISPR-associated-protein-Csn1
MMERILGIDTGTNSLGWAIVDKDENQYHLVAKGTNIFSEGVKIEKGIESSKAAERTEHRSVRKHYWRRKIRKIRLLTILSDNDLCPRLKHEQLRQWRLKKVYPTDDTFMEWQRTEDKAQVNPYKFRYICLTQKLDLSDITQRFILGRALYHLNQRRGFLSNRKEATKESEGTVKEGISSLSKDMKDSGCEYLGEYFYQLYQQGKKIRNHYTARKEHYLKEFKAICSKQELDDALIEKLEKAIFDQRPLKSQKGQVGTCTFEKGKSRCPSSHPLYEDFRMYSFINNIKVQVDTLYDKGERSLTDEEKQLIIPLFKRKSKRTFPFEDIAKKIAGKNNYCYIKSNEEKAYKFNYQMDTQVSGSPVNAQLEEIFGEDWLSSVCEVYTLANNKSRFQIMNDVWHVLFFYDDEDKLKEFAKDRLQLDDELAEKFSKISIPNDYAALSLKAIRKIMPYLRDYGLIYSEAVFLANLVDVLPQHVWGIKEMREAAIENVIDVMHSYDKNNIDGITLEGCVKTFLKERYQVSDDNLKKLYHPSMLDPYPRQRPNDEGVFQLGSPRISSVKNPMAMHSLFRLRKVVNLMLKKGYITPDTKVHIEFSRDLNDANKRWAIQTWQRENEKERERCRKEIEKYIASPSDTDILKYQLWEEQNHKCLYTGDEIRITDFLGDNPKYDIEHTIPRSAGGDSTKMNLTLCSSRFNRDEKKTKLPAELVNHDEILERISNWKEKYEDIDKQIRKISTKGATSKEDKDSKIRRRHYLILQRDYWRGKYQRFTMTEVPEGFSRRQGTDISVISRYARMYLKSVFKQVYIVKGIATSDFRKMWGIQDEYAKKERVNHVHHCIDAITIACIGKAEYDKLADYRHQYDDYLFQGKTKPTFDKPWPSFVIDIKHIQDELLIAHYAKDNLEKFTKKNLRGKDGRIIRDKFGNKLQMKGDTSRNSLHNDKFYGAINHEGEIKYVYRTNIEALDAKSIGNIVDPTVRSIIESAIAIHGSLKAAINKGIWMNEEKHIPIKKVRVFRNDVKKPIELKDQRDLSDKDYKQHYYVTNDGNYMMLIFSKLNNKGREIRQHVVINSLEATEVIKSHKRSQVGKVVWESYYSKEGFDLIYKLKSGTMILLYENNRDEVWDLDIRNLQKRLYIITKMKYDGRIYMMHHQEAREKKDLEEKSGSFKINEDYRPLIVNSYNQFNALVQDLDFEINDLGEIRRLI
>NC_014033.1|WP_013065591.1|1570048_1570357_-|CRISPR-associated-endonuclease-Cas2
MWLFVFFDLPVVTKKERKIAATFRKNLMKDGFVMLQFSVYIRHCASKESQAVHIKRVKSIVPETGMVSILSVTDKQYGDIVNFWGKEKSKKVPTDPLQLEFF
>NC_014033.1|WP_013064160.1|1568472_1568850_+|HEPN-domain-containing-protein
MDKELLIKLQKDKSHKMLADADEMVIQKRWDIAANRYYYACYHMLQALFISRGVSAKSHDGSLTHLGQDFILSGEVDKKFGRFFSRMVQLRHKADYNSIAEVTEDEVLEMQPLSKEFVEQVEAII
>NC_014033.1|WP_013065371.1|1568145_1568469_+|nucleotidyltransferase-domain-containing-protein
MTDKNRKVLDQIKAVARESAPKGSLVILFGSRARGEAKRGSDWDILIVLPKNRLEQSDYDDVSFPFVELGWKLNEQINPVMYTKAEWDASSITPFYDNVVRDGINLI
>NC_014033.1|WP_013064200.1|1567279_1568071_+|MBL-fold-metallo-hydrolase
MTWTVISDNRSNNPELETEHGLSILLQTERHKILLDTGASDVFMRNAEQMGINLSDVDYVFISHGHSDHAGGLRYLLEHNQQARIIVSPDAMSGKFFSKRGNLHSITTEWPEISNDRLILIDHACEIADGLRVIAHIPQTHPMPKGNQNLFIQDGYGDYIHDDFRHELALYSDGLLFTGCAHNGLENILSACPWPVHTVVGGFHLLDGLQSDEEITDLAQRLTTNYPNTHFYTSHCTGDHVFEVMKTIMPTHIHPFTCGTTKE
>NC_014033.1|WP_013064585.1|1566405_1567278_+|proline-iminopeptidase-family-hydrolase
MITEGYMPFMGYQTYYRIVGEASEKTPLLLLHGGPGSTHNYFEVLDCIAETGRQVISYDQIGCGNSYLDGHPELWTQKTWIDELIAIREYLQLDAVHILGQSWGAMQAIAYVIDHQPQGIKSLILSSGHASSSLWASEQHRLIKYLSDEDQEAIRHAEATGKWDDEAYLQANNHYFEQFVISVDEHSPECLRRPKRAGAEAYLYGWGPNEYQPLGSLKDFEYTDKLDQISQPTLICSGTRDICTPVVAASLYEHIPHSQWHLFRHSRHTCFIDAHQEYCQVLTKWLEEND
>NC_014033.1|WP_013065595.1|1565869_1566400_+|FHA-domain-containing-protein
MKRVRCPKCDQYITFDETKYEAGQSLVFKCPDCGKEFGIRIGVSKLRERQKDENPDEQANEQGCGSIVVIENVFHYKQVIPLRMGDNIIGRYQKGNPANTAFETVDPSVDLNHCTITVSRDKKGGLRYTLKDNNSNTGTFIDNVELTPKERRVISDGTLFTLGATSIILRTSNDEE
>NC_014033.1|WP_013063776.1|1576066_1578181_+|hypothetical-protein
MKITLLKKEGRKEVINRVELAEMASAIKNGMIEKTVRQTREVYHLMNPHRLSDGQITTQIEGGIKLPRICFVADYQNRKGDWRMLAYNGLVVLEVNDLQTYEEAVEIRELAKKLPETLMCFLGGSGRSVKIVCRGELFEGGLPKGEKDIRQFHLNLYNTARQAYQNQFGFDIQFLEPRLDRTVYMSADPEMGYNADARPFYADTNEHTLPQPVTISRDEDHLMPGRTVTRTYHLNWTFIVETIMGHYFDLPDENKEAELLMQIAARCLDEGIPQAHAKGLTMLHPVLNRDKMLVEKIFQTVYSVTEQEDYREKHKIKPLKSVPEDTIQAMKTEIFLNSNFDMRKNLLTGVAEYREKFSNDQRFKPLTEEVRNDMTLRATELGLKAWDRNVNRFIDSTRIEQFDPINTWLDQLPKWDGHDYIAELAARVPTSQPHWPKYLKYWLMGMVGQWRESDKQLTGNALTPLLIGRQGCGKTRFCKIILPPELRDYYNDKLNFKNEFDLNIALTSFALINIDEFDKTTSSQQIVLKYLLSSSDVKFRPPYGKTIKLYRRYTSFIGTTNQMKPLVDPTGSRRFVCVGVEGNIDFSDTLNHEQLFAQALYLFNKGERFWLNDDEIKQLMAENEPFQKLNDLVEMIGETFRRPKETEQGKWWSLGDISQVLATRYANFDPETPFQKIGNALNDVQFNFKSKRKTNHMEYWLIEK
>NC_014033.1|WP_013063514.1|1578214_1579576_-|multidrug-transporter
MRSYKVDIEVFERMPVARAVLAQSIPAIVAQLIVLLYNWADTFFLARLNKPELVAAATIVLPLYLMLTAIGNLPGVGGGSQFANHLGKHDYTGAQRVASITFWMGMILALVCCLSFPLYSDILLSLIGANERTLAPAKEYAFWVITIGGIPVIMNLVLANLVRAEGMALQASIGISAGGILNCLLDPLLMLPSMGNMGIVGAGIATAVSNMVSVLWLLVVIWRRRKTGVLTFAPQLLRYTRHYIGSISKVGFPSSIQYMLTVVAVAALTHFVAQYNTEATAALGIVKRLDYLPLYFTIGLSQGILPLLAYNHSSGNVVRRNHVFKCGCIISFGFAMLCFAVFEIWAYQLAMLFTQESLTVSYIVPFLRIQVVAMPFMAVCYPSITLFQAMERSREALICSILRKGVVDIPLLIVMNALWPLFGCMWVQPIVDFTSMLVAFYFSSQIRAQIHDY
>NC_014033.1|WP_013065449.1|1579584_1580859_-|FAD-dependent-oxidoreductase
MRVIIIGGGWAGTAAAIAARKAGAEVCLIEKTDMLLGCGNAGGIMRNNGRFTAAEEMIALGGGELFQLIDRIALHRNVEFPGHHHATLYPVNTIEAHVRRLVLEMGIDVHCSTHICDVVCDNNQLKGVYADSGDLFEGDVFIETTGSAGPMGNCLKYGNGCCMCVLRCPAFGPRISITERCGGQDYQGERQPDMFGVFSGSCKVSKESLSAALQEELNSKGVALIPLPKEEINYDKLKIKACKQYAIKDFSENMILLDTGDAKLMTSYYPVEKLRRLPGMENARYVDPCAGSKGNSIRYLSVAYRSNAMTVDGISNLLCAGEKSGLFIGHTEAITTGTLAGHNAARLAAAKPLLTLPQTLAVGDLIAAANSAIKERHDTMERFTFSGGNYFNRMKEKQLYTTDIEAIRLRVEQAGLLGVYNEHV
>NC_014033.1|WP_013063434.1|1580866_1581829_-|sulfide/dihydroorotate-dehydrogenase-like-FAD/NAD-binding-protein
MIINGLCADYGSRFCPCILAVTGGCVVCSQVNGKAFCDCKASGGICIKQELLRNGGKANPGRLTYECEVISVIHYDGLVFLRVKVPISLEREVKRPGGFVFVRRKDAASWYDVPISVQFEEMMVGSIGMTLLFRGVKTNQFKDLAEGDTLLLRGPFNNGLLGLQHLEAQQSSRCLILTKGIGLLPSVSAVRYLQSRHNETELYVDEGNFSPSILKFQLDLFELPFKPLTLLDDDGELSTPAKHVIRRFVADGGSLIHVGASEYVIHQVAAYLHYIGNRHVKLSACNNARMCCGEGVCGACTETTADKRVIHHCKEQVKIK
>NC_014033.1|WP_049769217.1|1582759_1583500_+|polysaccharide-biosynthesis/export-family-protein
MASCSTPRNFNYLQDLQNGQQTDITIDGTIKLQPNDQLTVIVKSKDPLMSNLFNKSMATQITQGNAAGNPYIAPYTVSPQGTIDFPVIGEILVGGLTRYEAEQTIKRELQKEQLKDANVTVELQNMTYTVTGEVKEPGVYKIEKDQITLLEALGKAGDLSQYGKRDSVMVIRTDGGKRKTYVLSLTDGQKLLNSEAFNIHQNDIIYVKANNVRARQSTANGNETRNASFWLSIVSVLTTVAVFLFK
>NC_014033.1|WP_013064213.1|1583510_1585064_+|chain-length-determinant-family-protein
MDLKTYINECKKHWRWFAATLATALIAAILFLLMFAPRYERSATVLIKDENGGGGLLSSMSASMGMLAGMAGINIASNVSNEMEIMSSPALLMEVINRLGLDTRYAAYDGLMKCDLWEETLPVKLTFPKLTDKDGAYLKMDLRKDGTFTLYKMRKNKEKLSGEVEGKVNTVCQTPIGPVSVIATKYFKQVMDEKGEMTIRITKERKYDQVERCMEQLDIDLTDDQTSIIHIGYRDQIAERAELIISTLINVYQEAWMNDKKNAADISTQFINERIKDIEQELSGLDKDIAQFRGSNLMPDYEEAAKMFMTNASLTYEQQVKVNNQLYMMEQMRNQVNHTEGTNQVLPANLLPDNENVAKQINEYNKLQLQRNQMAENSSDNNPLVKDLDVQLGSMRKAIVNSLDHGVAQLRASQKAVNREDQKLKQQISAAPSAVTKVLPAERQHKIIEALYIYLLEKREENSLTQVYNSQNLRIVSPPMGKLKPVFPKKGRTLAAAFLLGLCIPACIIYMRQRKKE
>NC_014033.1|WP_013064226.1|1585063_1586365_+|oligosaccharide-flippase-family-protein
MQNTIQKLSQQVLTSDIGKRIAYGAFWSMTGTALGKFLVLVAGIICARILGKEIFGEFGMVRSTVGIFIVLGSAGIGITATRFISLYRTTDQSHSYSIYRLSLLFAFCSGMVLTVCLMPMAKTISEVVLHSPHLSTAIQIAALILFASILNATLNGVLTGLEDFKSIAINTLIGSSIESILMVLGAWYYGLHGAIIGFGLGIAAQYIANHIAIRKDFKKYGITSTSHIERKDYSLIYSYCIPATLSALTVAPAFFIIRAMVVRATGYGELAIFEAADQWKVIILFIPTAVSQIVLPILSSTTDGKKFSKALLANIALIGIVSVVVAVIISILSPYIMPLYGSSFDNQTPLMLLAASTVFSSIANVIEMAVCSKEKMWQNFALNLVWATIMIVCAQMNINKGATGLALAVLISYAIKCILFSLYLKHINQHEDK
>NC_014033.1|WP_013064479.1|1586351_1587482_+|hypothetical-protein
MKISNHIEYGLLGVSLVLLQFAGYSVLTLPFLALTAVLMFSFKSLQTQVEESAPFSLFLVTAFIVGLVHLIFRDTTAKSLMMWGQLYFLAIILACASNKQKVISIIKYVIYAIFLADITSNILLAAGYSLPWTHFPPIRPGEILPRFPGVKSSSLFSGSISFLALCCIIQEPIKPKWLKFFIEFMMCINLLLAGSFRYYIILAAVIGLYVLKLYRKPKLLISFYICFIVFVVLFTYLTKDISQSNMLRWKLWLHTIDHISDSPIWGIGFYFQYLREHTIFTFHNLAVAGVTESTILLFAWCFGLPIMVIFLYALYKTLRQFSNYSEYKLFLGLFLGLSLDLFWGGSLDNCMSLSIFLLCMYQINHDEKVQHHHTNL
>NC_014033.1|WP_013065078.1|1587447_1588206_+|glycosyltransferase-family-2-protein
MKKFSIIIPTYNQLPLLKRALESVLHQQDADYEVIVTDDSDNEDIATYIQSIGNQSVKYFYHKSTGRAADNWNFGLSKAEGQYVIVMHHDEAMASSNHLSLMAQALTDADVAIADIEVMNGGKQSSRWLSHLTRKLCCKHPECLFLQNAIGPTACIAFKRDQLQSFNPNLKWLVDIEWYYRLLKGKRVTICKRCKIQSTHGHAEQISQQLDIMQAFSQDKAIICQTHGNAVRLMLWLYEHLILGTKRLLRRI
>NC_014033.1|WP_013063247.1|1588202_1589072_+|alpha-1,2-fucosyltransferase
MRIVKVLGGLGNQMFQFALYKALQKQYPEERVLLDLHCFNGYHKHRGFEIDSVFGVTYEKATLKEVASLAYPYPNYQCWRIGSRILPVRKTMLKEEPNFTLEPSALSLPDSTYYDGYWQHEEYFMHIREEILSTYAFPAFDDERNKTTAQLAASTNSCSIHIRRGDYLTDPLRKGTTNGNYVIAAIKEMQQEVKPEKWLVFSDDIAWCQQHLASTLDATNTIYIDWNTGANSIHDMHLMALCRHHIIANSSFSWWGAWLSQQDGITIAPSNWMNLKDVCSPVPDNWIKI

Crispr_ID: NC_014033_6

• CRISPR_ID: NC_014033_6
• CRISPR_location: 1785624-1785822
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers
• Cas_protein_info: WYL

Consensus repeat of NC_014033_6

Consensus_repeat	Method
CAGCGTCGTGGCGGGCAGCGCGGGCGCTGTGGTCAGGCTGCTGCAG	PILER-CR

spacers of NC_014033_6

>6.1|1785670|32|NC_014033|PILER-CR
TTATAGAACATACTATTGTAGCAGTTGTCGGC
>6.2|1785748|34|NC_014033|PILER-CR
AGCCCTGGAACATAGCATAGTAGCAGTACTCCTT

CRISPR arrays and Neighbor proteins around NC_014033_6

CRISPR arrays

The CRISPR arrays of NC_014033_6

>merge|NC_014033|6|1785624-1785822|PILER-CR
CAGCGTCGTGGCGGGCAGCGCGGGCGCTGTGGTCAGGCTGCTGCAGTTATAGAACATACTATTGTAGCAGTTGTCGGCCAGGGCCGTGGCGGGCAGCGCGGGCGCTGTGGTCAGGCTGCAGCCCTGGAACATAGCATAGTAGCAGTACTCCTTCAGCGTCGTGGCGGGCAGCGCGGGTGCTGTAGTCAGGCTGCTGCAG

>NC_014033|6|3|1785624-1785822|PILER-CR
CAGCGTCGTGGCGGGCAGCGCGGGCGCTGTGGTCAGGCTGCTGCAG	TTATAGAACATACTATTGTAGCAGTTGTCGGC
CAGGGCCGTGGCGGGCAGCGCGGGCGCTGTGGTCAGGCTGCAGCCC	TGGAACATAGCATAGTAGCAGTACTCCTTCAGCG
TCGTGGCGGGCAGCGCGGGTGCTGTAGTCAGGCTGCTGCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014033.1|WP_157054458.1|1788072_1788177_+|smalltalk-protein	unknown	unknown	unknown
NC_014033.1|WP_049769109.1|1776517_1776748_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013064498.1|1789900_1791052_-|lipase/acylhydrolase	unknown	unknown	gnl|CDD|238868
NC_014033.1|WP_013063220.1|1791566_1791869_+|nitrous-oxide-stimulated-promoter-family-protein	unknown	unknown	gnl|CDD|371708
NC_014033.1|WP_148214885.1|1779439_1781077_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_041385933.1|1779071_1779443_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013063847.1|1783602_1784103_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013065290.1|1778577_1779045_-|hypothetical-protein	unknown	unknown	gnl|CDD|311960
NC_014033.1|WP_013065437.1|1791883_1792177_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_041385940.1|1792971_1793403_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|225064
NC_014033.1|WP_013063914.1|1787469_1788006_+|DNA-binding-protein	unknown	unknown	gnl|CDD|375718
NC_014033.1|WP_013064110.1|1792179_1792815_-|lactate-utilization-protein	unknown	unknown	gnl|CDD|376839
NC_014033.1|WP_013063810.1|1791073_1791448_-|thioesterase-family-protein	unknown	unknown	gnl|CDD|227783
NC_014033.1|WP_013063710.1|1782600_1782885_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013063303.1|1788278_1789529_-|HipA-domain-containing-protein	unknown	unknown	gnl|CDD|377920
NC_014033.1|WP_013064254.1|1777376_1778411_-|Fic-family-protein	unknown	unknown	gnl|CDD|225718
NC_014033.1|WP_013063413.1|1784281_1785172_-|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl|CDD|379100
NC_014033.1|WP_143040044.1|1781836_1782511_-|Rha-family-transcriptional-regulator	unknown	unknown	gnl|CDD|378235
NC_014033.1|WP_013064650.1|1783148_1783589_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013065100.1|1789525_1789825_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|213767

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_014033.1|WP_013063413.1|1784281_1785172_-|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	2.2e-42	139.7	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014033.1|WP_013064498.1|1789900_1791052_-|lipase/acylhydrolase	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	9.70925e-42
NC_014033.1|WP_013063413.1|1784281_1785172_-|WYL-domain-containing-protein	gnl|CDD|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	1.53706e-36
NC_014033.1|WP_013065290.1|1778577_1779045_-|hypothetical-protein	gnl|CDD|311960	pfam08291, Peptidase_M15_3, Peptidase M15.	2.31488e-20
NC_014033.1|WP_041385940.1|1792971_1793403_+|GNAT-family-N-acetyltransferase	gnl|CDD|225064	COG2153, ElaA, Predicted acyltransferase [General function prediction only].	8.21253e-46
NC_014033.1|WP_013063914.1|1787469_1788006_+|DNA-binding-protein	gnl|CDD|375718	pfam18291, HU-HIG, HU domain fused to wHTH, Ig, or Glycine-rich motif. Rapidly-diverging family of HU domains predominantly observed in the bacteroidetes lineage with a predicted role in recognition and possible interception of the DNA of parasitic elements, a counter-conflict strategy preventing incorporation of these elements into the host genome.	1.3784e-15
NC_014033.1|WP_013064110.1|1792179_1792815_-|lactate-utilization-protein	gnl|CDD|376839	pfam02589, LUD_dom, LUD domain. This entry represents a domain found in lactate utilization proteins B (LutB) and C (LutC), as well as several uncharacterized proteins. LutB and LutC are encoded by th conserved LutABC operon in bacteria. They are involved in lactate utilization and is implicated in the oxidative conversion of L-lactate into pyruvate.	3.5081e-44
NC_014033.1|WP_013063303.1|1788278_1789529_-|HipA-domain-containing-protein	gnl|CDD|377920	pfam07804, HipA_C, HipA-like C-terminal domain. The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.	1.94403e-60
NC_014033.1|WP_013064254.1|1777376_1778411_-|Fic-family-protein	gnl|CDD|225718	COG3177, COG3177, Fic family protein [Function unknown].	1.50796e-19
NC_014033.1|WP_013063220.1|1791566_1791869_+|nitrous-oxide-stimulated-promoter-family-protein	gnl|CDD|371708	pfam11756, YgbA_NO, Nitrous oxide-stimulated promoter. The function of ygaB is not known but it is a promoter that is stimulated by the presence of nitrous oxide. It is regulated by the gene-product of the bacterial nsrR gene.	1.13417e-37
NC_014033.1|WP_143040044.1|1781836_1782511_-|Rha-family-transcriptional-regulator	gnl|CDD|378235	pfam09669, Phage_pRha, Phage regulatory protein Rha (Phage_pRha). Members of this protein family are found in temperate phage and bacterial prophage regions. Members include the product of the rha gene of the lambdoid phage phi-80, a late operon gene. The presence of this gene interferes with infection of bacterial strains that lack integration host factor (IHF), which regulates the rha gene. It is suggested that Rha is a phage regulatory protein.	9.9729e-21
NC_014033.1|WP_013063810.1|1791073_1791448_-|thioesterase-family-protein	gnl|CDD|227783	COG5496, COG5496, Predicted thioesterase [General function prediction only].	1.26591e-33
NC_014033.1|WP_013065100.1|1789525_1789825_-|helix-turn-helix-domain-containing-protein	gnl|CDD|213767	TIGR03070, couple_hipB, transcriptional regulator, y4mF family. Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions].	1.38885e-05

Protein sequences

>NC_014033.1|WP_013063413.1|1784281_1785172_-|WYL-domain-containing-protein
MKPAQIFHQYIWLINTLKVHRALTLDELDRKWRDDGVTDGNQLTRSTLTRHRRSIFDMFGIIIEADSSTYKYSIRNADVLANGSIAHWLYNTLSVHGVLAESVGLKERMVLENIPSGAEYLSTIIHAFHTGRRLRMGYQKFNGEGYVKTVCPYALKLFHQRWYLLALNDEQQLRIYALDRISELSTTDDLFEMPDDFSPQDYFSEYFGVLTTDTPMAHVVIRAYDYTPNYLRTLPLHHSQREVATAESYADFTFDIRPTHDFLSQLLSHGAGIEVLSPPDVREQMRQKFAEGLKRY
>NC_014033.1|WP_013063847.1|1783602_1784103_-|hypothetical-protein
MEQNYEDLKAWQDGARRMLENDIEQMKEKLEQKLNLVRLMELTDELLTKIDRLNSELQDERAQRQAAEVKLSELNKLSAGVARKSPQVDILKAMRSYLKISKRKNLAKREAAKMVFTELCASAQMDFPEDIMEELSHLDDEQLEPKVVNVAGNYNDIHDNSSVTRI
>NC_014033.1|WP_013064650.1|1783148_1783589_-|hypothetical-protein
MAGNNIYVQGSYVDIHDNEVVNLSVDKAQVRVGDHQVMSQQSDVPEVKMLVESVDEVRDFFWGDSSMAVIFGVCRDCFQYADNMSQFERDFGCVEGLISNTFRHNPYMRLAVGKWEQQGAKQRVLRLVDAYKNEVSKRLKLQTLTE
>NC_014033.1|WP_013063710.1|1782600_1782885_-|hypothetical-protein
METKILKVVRQGEAFGVQSSKTENGTIQKCNIVLREMGGSKFENEYVCAMLGNLAACRFYEGDVVAATLRFSTHEYQNQVFQEILCTDIVKLNK
>NC_014033.1|WP_143040044.1|1781836_1782511_-|Rha-family-transcriptional-regulator
MMTQIININKVQTITSLEIAELTGKQHKDLMKAIRNMEPAWEKVHGRKFALMFREVKIGNGAVRHAPCYQLTKTECLYIATKFNDEQRAKLVLRWEHLELQELERKQQLALPSPKKILALADEIIGEGLRMLNEPAEDTLTATQVAKTFNMTTYDFNAILRDMGIQYRRDGHWNISDDLADRNLTRLRTHVSYSLKGQKKVKVYMTWTLDGVRFLNAKLGYPNF
>NC_014033.1|WP_148214885.1|1779439_1781077_-|hypothetical-protein
MQKDYNGMAFGEIIAKYWELYNGGKVPTVGDRNALTFELAVTIRSICGYDLEQLMQVIPNYWAAPDGTCTQDDMDEYQKTIENALKEPRKGMPYRLKQVLQALKSQAGIKACGGTMTAPPPMPKKLPPLIKLLTKNVPWYYKPAVASAVFPALGAHLHGVKFRYWDNVEHEATFMNLLVGRQSIGKGSIKKPIDYIMEDIRQRDQPNREREAEWKRKNPTGKQKKDPRPADICIQMLIDNLTDAVFNQRIVDAHNNGQRYIFTIVDEVEALKKVTSKNSVDEVGLLIRKAFDNSLAGQERVGADSVSGIAPLRWNFNASTTPPNARKFFYKMVNDGTVGRLDVATIIRNDDDDDEPPIQGIYDEQFAAELKPYIDRLEAANGLIECPQAKKLSLDIRIENKEAAKLFESEAYRVLSYRANVISWLKGMLLYVAHGYRWDKTIADFVRWSEQYNLWCKMLYFGDQLEKELREEVEIQRRSGPKNLLRLLPDEFTREQYMLMRQQQGRQGDGDSALRQWQTRGHLVYDEVSRRYCKTEQFKQKYANL
>NC_014033.1|WP_041385933.1|1779071_1779443_-|hypothetical-protein
MIQVDNTRECFVQLWLRLERTRRLLGMQCKRYCIRNILKLWFGPQANDDFIWHVCHLCEQEGWNELPKPSLYPRKHRELLRAIVAVRTVISYYKIDLKALDSAYSQAFPHSTPLNVNKKRKVN
>NC_014033.1|WP_013065290.1|1778577_1779045_-|hypothetical-protein
MESIVQLNSNANLSEHFTLGEMTKSSSHPEVYNIPSHEAIANLKRLCTWLEALRERTGRSIVINSGYRSPQLNRKVGGAPTSNHLTGCAADIRTSGMEQAITYAAILLAYARESQQEFDELLIEKNRYGAVWLHFAVRPSTPSSKNRHKVAFIQA
>NC_014033.1|WP_013064254.1|1777376_1778411_-|Fic-family-protein
MDIARELLQYLHYHPLSTRDDIAKGIAFEGSDATMKRMIASGVKDGSIVVEGKARATRYRLSDQAHLLMPLNLDTYFSQDQDKRQVQTSFNFDLIRQQLPVVTLFTDDEIALLNELQAEFKQHISEMTENEYRKEMERLGIDLSWKSSQIEGNTYSLLETERLLRESKTADGKTKEEAVMLLNHKDALRFVLDNPDYLQHLTISHIEDIHQLLTKELSVDRGIRHRRVGITGTNYHPLDNEFQIREALHDTCDLINSKENVFEKALLTLVLLSYIQAFADGNKRTARITSNAILIANGYCPLSFRSVDSIDYKKAMLIFYEQNNLYAFKKIFIEQFEFAVREYF
>NC_014033.1|WP_049769109.1|1776517_1776748_-|hypothetical-protein
MSYSELAQMELMNAINSIKSESELIEFRNMLAKYFAGKAQKAIDALWDNGAINNDTIEEWGKEHMRTPYKYEANRS
>NC_014033.1|WP_013063914.1|1787469_1788006_+|DNA-binding-protein
MALKVKAQEKLQKIGKYEGTYRYIMMPELYTSLSQDKVIKEAALRSGVSKGIMQACWDAAGEVIKAWATEGHSVALPGLGTMRFGIRAKSVAKVDEVKAGLVTSRRIIFTPAVDLKEELAGTAIQITCYDRDGKEIKRVTSTDPGTVEDPDQPSNGGNTSGGGNTGGNGGNHNEPIGD
>NC_014033.1|WP_157054458.1|1788072_1788177_+|smalltalk-protein
MTKKETLKFIVQMIASIATAIVTALGATSCMGAM
>NC_014033.1|WP_013063303.1|1788278_1789529_-|HipA-domain-containing-protein
MKKITVFADFDFLATPQEIGTLGYERIRGKDHFVFEYSREWLKKHGGIMLSGDLMNVPSLQHPRGADSVFGFVKDSFPDRWGRLLLDRRERLKAQAESRPVRMLTNFDYLTGIEDFTRMGGIRYRDEDSDSYMNDSAKFLVPPIESLRALCDACHEIESAEERNELPEQRWIDQLIDPGTSLGGARPKANVIDADGKLYVAKFPSKKDLENTELIEHFSHRLAAAAGINVANTHTIKISKDRHLLLSERFDRTADGRRKHFASAMSLLGFDDGAGSSTGNGYLDIVDFILQGCVDVQQNLRELYRRVAFNVMFGNTDDHFRNHGFLLTPKGWTLSPAYDINPGTKLHQCLLIDQYTEQSDANTLLHASGSYMFEQQEASEIIDQVRTAIKDWRATATELQVPLKILEPYCNRWDNL
>NC_014033.1|WP_013065100.1|1789525_1789825_-|helix-turn-helix-domain-containing-protein
MGKNTFGKTMPRALAQQLQLMGEQIMLARKRRHLSMQDVADRATVTRLTVSKVEHGDPTVSMGIYARVLFALNLEKDISLLAADDALGRQLQDAELLSK
>NC_014033.1|WP_013064498.1|1789900_1791052_-|lipase/acylhydrolase
MNNTDLKWVACWGNATSITDRREAVYAKNLTLRYPVRMPFAGSALRFRFSNLTGTEPVTLSKVFVGHTPITFGGAISVTLQPGNEVESDAISYAVHRGDTVDVSMYLADFTQMNSGTLITGPLSKGFYAYGDFAEADELPLDLTRHTNWFYFLNTIDVLTSPDNHAVVCYGDSITAQSWPDYLAQLAFGTNVSIIRRAVSGTRILRQYDCITYQAYGLKGATRFPIEMRVAGATDVIIQHGINDIIHPVGEDVNPFRPWSDLPTVEEMQRGVEDIYVKPAKAMGLKVWSGTLLPIYGWRTYNEKRDAMRSEFNEWLRTSPVFDGCIDFDAAVRCATNPKAFADGFDSGDHLHPSERAYEAMAQAAAHKLIRHIPSTYDHEEQY
>NC_014033.1|WP_013063810.1|1791073_1791448_-|thioesterase-family-protein
MIEVGLKHTSTLVVTDDVTAVKIGSGDMAVLATPAMMALMENAAMLAVADALPEGSTTVGGHIASSHLKPSKVGDTVTATAEVVKVDGKKIEFKVSAYQGDVLIGEGSHLRFVVDRERFMSKLG
>NC_014033.1|WP_013063220.1|1791566_1791869_+|nitrous-oxide-stimulated-promoter-family-protein
MSKIEREKQTVRKMIELYCRHHLHQETMTEEYQHLADYACQRLDHCRFGEKKTVCKRCPIHCYAPQEREAIRKVMRWTGPRMMIYAPKAAIIHTYYMLKR
>NC_014033.1|WP_013065437.1|1791883_1792177_-|hypothetical-protein
MAWKLKYRCKQCGYEAEVYEGRGLFRQEITAVSCPDCHTIQNLVVGGIIADVAPSYRSEVGRLCLQCGSDKIRVWDKHTCPKCNGEMEPTGEKEFWT
>NC_014033.1|WP_013064110.1|1792179_1792815_-|lactate-utilization-protein
MTPQKQRNELLAQTIIKNLKRRHIEGFYCATAEEAVKKVSDLIADGSSVTWGGTMTVRDLGIPQYLKDRGTLEVLDRDLAETPEEKQSVYLKAFSADVYLSSANAISEDGVIVNIDGNGNRVAAITWGPKKVIFVIGLNKVAQNVEAALARARSTASPINAARFDIHTPCHTDGVCHNCNSPECICSYVHFLRNSPQGRHVVVLVGETLGY
>NC_014033.1|WP_041385940.1|1792971_1793403_+|GNAT-family-N-acetyltransferase
MTTNELYELLRVRSEVFVVEQNCVYQDMDGDDQKSIHLWLTVADKIVALARVCPAGTHMKEISIGRVITTERGKGYGKQIMLHAIEAAENHFGATLIDIEAQEYAKGFYENVGFEQSSDTFMLDGIPHIKMTWTKDLAAVSRG

Crispr_ID: NC_014033_7

• CRISPR_ID: NC_014033_7
• CRISPR_location: 1935719-1935843
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014033_7

Consensus_repeat	Method
ATACAAAGAAAAACGAGTTTTCCTTTGGTATTTCGCTC	CRISPRCasFinder

spacers of NC_014033_7

>7.1|1935757|49|NC_014033|CRISPRCasFinder
GCTTATTCGTATATTTGAACTCCGTTCGAAGATAGGCTGCACCTCGGAA

CRISPR arrays and Neighbor proteins around NC_014033_7

CRISPR arrays

The CRISPR arrays of NC_014033_7

>merge|NC_014033|7|1935719-1935843|CRISPRCasFinder
ATACAAAGAAAAACGAGTTTTCCTTTGGTATTTCGCTCGCTTATTCGTATATTTGAACTCCGTTCGAAGATAGGCTGCACCTCGGAAATACAAAGAAAAACGAGTTTTCCTTTGGTATTTTGCTC

>NC_014033|7|6|1935719-1935843|CRISPRCasFinder
ATACAAAGAAAAACGAGTTTTCCTTTGGTATTTCGCTC	GCTTATTCGTATATTTGAACTCCGTTCGAAGATAGGCTGCACCTCGGAA
ATACAAAGAAAAACGAGTTTTCCTTTGGTATTTTGCTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014033.1|WP_177168139.1|1919827_1920748_-|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl|CDD|197317
NC_014033.1|WP_177168138.1|1929480_1930227_-|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_014033.1|WP_041385981.1|1928181_1929471_+|MFS-transporter	unknown	unknown	gnl|CDD|341042
NC_014033.1|WP_013063336.1|1944050_1944407_-|response-regulator	unknown	unknown	gnl|CDD|381099
NC_014033.1|WP_013064648.1|1942214_1944020_+|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl|CDD|237874
NC_014033.1|WP_013063223.1|1930938_1934307_-|transcription-repair-coupling-factor	unknown	unknown	gnl|CDD|224118
NC_014033.1|WP_143010881.1|1927254_1928055_-|hypothetical-protein	unknown	unknown	gnl|CDD|373010
NC_014033.1|WP_148214888.1|1920787_1922362_-|carboxylesterase-family-protein	unknown	unknown	gnl|CDD|238191
NC_014033.1|WP_041385982.1|1935373_1935559_+|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013063039.1|1941328_1941727_-|hypothetical-protein	unknown	unknown	unknown
NC_014033.1|WP_013063137.1|1939167_1940499_-|dihydroorotase	unknown	unknown	gnl|CDD|181716
NC_014033.1|WP_013063502.1|1935882_1936632_+|polyprenol-monophosphomannose-synthase	unknown	unknown	gnl|CDD|133062
NC_014033.1|WP_013065717.1|1918208_1919771_+|DUF4957-domain-containing-protein	unknown	unknown	gnl|CDD|374487
NC_014033.1|WP_033149828.1|1930402_1930828_-|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl|CDD|107221
NC_014033.1|WP_013063767.1|1940464_1941238_-|DUF4369-domain-containing-protein	unknown	unknown	gnl|CDD|379543
NC_014033.1|WP_013065494.1|1925657_1927262_+|L-lactate-permease	unknown	unknown	gnl|CDD|224535
NC_014033.1|WP_013064415.1|1936651_1937413_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|153251
NC_014033.1|WP_013063100.1|1938355_1939171_-|5-methyltetrahydrofolate--homocysteine-methyltransferase	unknown	unknown	gnl|CDD|376973
NC_014033.1|WP_013064307.1|1937409_1938345_+|metallophosphoesterase	unknown	unknown	gnl|CDD|277331
NC_014033.1|WP_013065368.1|1941710_1942070_-|septum-formation-initiator-family-protein	unknown	unknown	gnl|CDD|368217

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014033.1|WP_177168139.1|1919827_1920748_-|endonuclease/exonuclease/phosphatase-family-protein	gnl|CDD|197317	cd09083, EEP-1, Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1. This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.	4.2682e-109
NC_014033.1|WP_177168138.1|1929480_1930227_-|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.31209e-37
NC_014033.1|WP_041385981.1|1928181_1929471_+|MFS-transporter	gnl|CDD|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.38513e-60
NC_014033.1|WP_013063336.1|1944050_1944407_-|response-regulator	gnl|CDD|381099	cd17546, REC_hyHK_CKI1_RcsC-like, phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC. This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	5.20031e-38
NC_014033.1|WP_013064648.1|1942214_1944020_+|DNA-polymerase-III-subunit-gamma/tau	gnl|CDD|237874	PRK14971, PRK14971, DNA polymerase III subunit gamma/tau.	0
NC_014033.1|WP_013063223.1|1930938_1934307_-|transcription-repair-coupling-factor	gnl|CDD|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NC_014033.1|WP_143010881.1|1927254_1928055_-|hypothetical-protein	gnl|CDD|373010	pfam14315, DUF4380, Domain of unknown function (DUF4380). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 288 and 372 amino acids in length. There are two completely conserved residues (G and E) that may be functionally important.	2.97154e-06
NC_014033.1|WP_148214888.1|1920787_1922362_-|carboxylesterase-family-protein	gnl|CDD|238191	cd00312, Esterase_lipase, Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.	8.94913e-131
NC_014033.1|WP_013063137.1|1939167_1940499_-|dihydroorotase	gnl|CDD|181716	PRK09236, PRK09236, dihydroorotase; Reviewed.	0
NC_014033.1|WP_013063502.1|1935882_1936632_+|polyprenol-monophosphomannose-synthase	gnl|CDD|133062	cd06442, DPM1_like, DPM1_like represents putative enzymes similar to eukaryotic DPM1. Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.	2.85022e-100
NC_014033.1|WP_013065717.1|1918208_1919771_+|DUF4957-domain-containing-protein	gnl|CDD|374487	pfam16318, DUF4957, Domain of unknown function (DUF4957). This family consists of uncharacterized proteins around 150 residues in length and is mainly found in various Bacteroides and Prevotella species. The function of this protein is unknown.	1.19591e-36
NC_014033.1|WP_033149828.1|1930402_1930828_-|Hsp20/alpha-crystallin-family-protein	gnl|CDD|107221	cd06464, ACD_sHsps-like, Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.	1.36106e-25
NC_014033.1|WP_013063767.1|1940464_1941238_-|DUF4369-domain-containing-protein	gnl|CDD|379543	pfam14289, DUF4369, Domain of unknown function (DUF4369). This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with pfam00578.	3.13898e-20
NC_014033.1|WP_013065494.1|1925657_1927262_+|L-lactate-permease	gnl|CDD|224535	COG1620, LldP, L-lactate permease [Energy production and conversion].	1.99486e-95
NC_014033.1|WP_013064415.1|1936651_1937413_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	2.14767e-55
NC_014033.1|WP_013063100.1|1938355_1939171_-|5-methyltetrahydrofolate--homocysteine-methyltransferase	gnl|CDD|376973	pfam02965, Met_synt_B12, Vitamin B12 dependent methionine synthase, activation domain.	5.16012e-123
NC_014033.1|WP_013064307.1|1937409_1938345_+|metallophosphoesterase	gnl|CDD|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.68915e-54
NC_014033.1|WP_013065368.1|1941710_1942070_-|septum-formation-initiator-family-protein	gnl|CDD|368217	pfam04977, DivIC, Septum formation initiator. DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation. These proteins are mainly composed of an amino terminal coiled-coil.	8.10859e-06

Protein sequences

>NC_014033.1|WP_041385982.1|1935373_1935559_+|hypothetical-protein
MSNKEIQEFNEKLRRGLELAEKRMLQEKALRNQDVVVCGADQVIRRIPAKQVIADNPIFQD
>NC_014033.1|WP_013063223.1|1930938_1934307_-|transcription-repair-coupling-factor
MKIEELEKVYAKLPQVAALAHEIENAATRRIFLEGLLASSAPMLFGSLAAKCKSPILFILQDAEEAGYFYHDLTQLLGTRQVLFFPSSYRRAIKYGQLDSASQILRTEVMTQIDKSVFIVTYPEALAEMVVPKQTLNDRTVVIEKGQEVPVGDITKQLRELGFNEVDYVYEPGQFALRGSILDVYSYSCEYPYRIDFFGDDVESVRTFQVEDQLSLDARDRVEIVPELEADEAAQEPFLSLLPQDTIIATKDYLYVRDAIDAAFQEDMPLVTGVQFMHQAEGFRRIEFGHRASISDCSIIRFDITIQPLFHKNFEMLFQAFDNYLHQGYQVYILADSAKQNERLKDIFAQRAENEGEHAQIRFTPVDKTLHEGFIDDDLKVCFFTDHQIFDRFHKYNLKSDKARSGKMALTLKEIQQFEIGDYVVHVDHGVGRFGGLVRMPQGDGYQEMIKLTYQHGDAIYVSIHSLYKVAKYKSQDNGEAPRLSTLGTGQWERLKERTKQHIKEIARDLIKLYAKRRKEKGFAFSRDSYLQHELEASFLYEDTPDQLKATQDVKADMEKARPMDRLVCGDVGFGKTEVAVRAAFKAAVDGKQVAVLVPTTVLAYQHFRTFSNRLKDMPVTVDYLTRARTTKDTNRIQKDLAEGKIDIIIGTHRLISKSVKFKDLGLLIIDEEQKFGVSTKEKLRQMKTSVDTLTMSATPIPRTLQFSLVGARDLSVIQTPPPNRYPIQTEIHTFSPEIIAEAVNYEMSRNGQVYFVNNRISDLQHIAEIIQKYVPDARICIGHGQMKPEELEKIILDFSNYDYDILLSTTIVENGIDIPNANTIIINGAHNFGLSDLHQMRGRVGRGNRKAFCYLLAPPLSALNPESRRRLEALENFSDLGSGINIAMQDLDIRGAGNLLGSEQSGFIADLGYETYQKILSQAMSELKNEEPEFLASAESAASAADSAAGKTSPASLASETSNISWVDDCALDSDIEMYFPDQYVPSDSERMLLYRELDNLANSTQLELQLDAYRKRLVDRFGAIPAVSEELILVVPLRVAGKQLGIEKIMLKQQKMFFYFVSRDDSPYFQSEAFGKILQYVSRYPRKCNFREGKGKHSVVISEVPTVASALTICQEIMSI
>NC_014033.1|WP_033149828.1|1930402_1930828_-|Hsp20/alpha-crystallin-family-protein
MMPVMRTNSWIPSVFADLFDTEYMPKANCTAPAINVKESDKAYTVELAAPGMKKEDFNVHINDEGNLIIKMEQKQEHKDEDKNMRYLRREFSYSKFEQTLILPDDVKKEDIKARVENGVLTVELPKIEEEKVKLSRQIDIA
>NC_014033.1|WP_177168138.1|1929480_1930227_-|HAMP-domain-containing-histidine-kinase
MRLRNEIGRAQRSERIKTVFMANVSHALRTPLNAIITDSQKLLDNEESDPKKLKAMMTTINQNGKQLLYFISQLLELSSFDSNMATFTLIEVNLAELIASYRREAQRDAGANVQVVVRSPLSPHAKGMVDTNLMYQLMTHLLHNALAHTQEGTITIDYDYADNGLKIEVIDTGDGEPQDFKSNFSTLIQGNDSLALFNQRSGLGLSICKSIVEGLHGTIDLKSEKGKGTHVTVWIPCKMRDMKKGLVR
>NC_014033.1|WP_041385981.1|1928181_1929471_+|MFS-transporter
MDKLWNRNYCKVMAANFTLFFAFYVLTPLLPLYLSEHFGATKDVIGLVLSGYTITALLFRPFSGYVVDSFPRKMVLMVSFSVFAIFFAGYLAASTLLLFTIVRTLHGGPFGALTVANSTVAIDVLPSSRRTEGIGYYGLSNNLAMAIAPTIGIFIYQLTNSFEFLFWLALIVATTGWLIDSTVKLKPRDSSQARSSRLSLDRFFLTRGWLLGLNMVAFGFSFGVLSNYLAIYGKEVMGITGGTGTYFMLCSVGLILSRLQGSKALRDGRVTHNAATGMVISLVGYTLFILMPTLAQSSMVNGQCSMVNGQCSMVNGQWSMFNGQWSMFIGYYGSALLIGLGNGHMWPAFQNMTINVATNKQRGTANSTILISWDIGMGLGILAGGIVAELISYSAAFWTVVLVNGTGVATYFLATRAFFLRRNLNPTVR
>NC_014033.1|WP_143010881.1|1927254_1928055_-|hypothetical-protein
MKRIVMLSAVALLMSSAAMAQTKEVKIGDVTMTITPEKGAKITSLKYQDQEVISQLRWPESFGSTFWTSPQKEWNWPPVFELDKGVYEVVEKDGHLVMTSPVSEKLKYRVRKDFSTDKKDGAIVITYSIINESGEERKVAPWEITRVPNAGVIKFDAPVESIWPAGLMNFEQKDGVACYAADEAQQNRKVNADGKGWLSYENNGLVLTKKFADLKADEPAPGEAEIQVYVNRGKTYIELESQGAYTTLAPGAELSWTVRWYLQPAK
>NC_014033.1|WP_013065494.1|1925657_1927262_+|L-lactate-permease
MSALVSAIPILLLIVLMMGFKVSGYKSAIVTLIVTVVLALFAAPALGIVPEKYAQASIVGITLWSVVEGLLKACFPIILIIICAIFSYNILCETKEIETIKTQFIQMTSDKGLLVLLLTWGLGGVLEGMAGFGTAVAIPAAILIGLGFKPMFSAVICLIANTVAVGFGAVGLPATTLANQVAASGTATPEELCEVATFIILQLSLMFFITPFLILMLTDKTKVVKNICIALFVGSFSIIVQFCCAHFIGPETPAILGSVAAIAAMLIYNKLFIHDENPNDEVKVEKKNFGLVKTLKAWSVYGLIIFFILISSKIVPPVNELLGSTLVTKFELPVIGNTFKFGWLSNAGLMIFLGAVIGGLIQGMSIGALLKLLAKTTLNLQKTVVTICCLVAMAMLMNNVGMTNDIAKGLVMLTGVAFPFFAPLIGSIGTFVTGSATNANILFGKLQATAATDLGLVNQGTFFGVSGSETNWLAAANCAGSEGGKLLSPQSIAIATAACDMEGQDGDIMRKTMPFAIFWILMNGLMVFLGLHVI
>NC_014033.1|WP_148214888.1|1920787_1922362_-|carboxylesterase-family-protein
MMKVLLRRLMLVAVVMATSFVAEAQPLLATHVETGDVQGVLDDGLAVYKAIPYAAPPVGNLRWRAPQPAKAWEGVRVCDEFGKMPPQPTRPGRTADMMSEDCLYLGIATPAKTVNDKLPVMVWIHGGGFQTEWYGGDLWKHLALRGVVIVSIEYRTGALGFMAHPELTKESKDGHSGNYGLLDQIYALQWVQRNIAQFGGDPDQVTIFGESAGAISCSMLCASPLARGLFHRCISHSGGSFAPWSDAPRSLGLDASQKGAEQQGVAFMKHLKKKNLKQLRAMDAMALCDGNVGFAGFWPCVDGYVICDDQYRMYERGEYNDVPVIVMTNSDEGALFAPGNITAEDYQKTLKSIFGAWADEALKFYPGATNDEAWHGFGDAFRDMGFAWPSYAWVSLQAKTGKSAAYAAYLAQPSEMSFSRDPRRKGVAHADDIMYLNGMFLDQPQKYPTESALAEIIQQYWVNFAKTGNPNGKGLPYWPTFDESKPTTMQFSNGASLINVPNREQIDFVDRYYRAKRAEVESNR
>NC_014033.1|WP_177168139.1|1919827_1920748_-|endonuclease/exonuclease/phosphatase-family-protein
MKVFSKLMLVAMMMAASITTQAQELYVGSYNIRYQNDGDAKAGNAWQQRMPVLCGQILFEHPDIFGAQEVLESQRQDLLKQLTDYDCIGLGRDDGKHAGEHSNIFYDRNKIKLLDHGDFWLSETPEKPGLGWDAACVRICSWGYFKLKGTSLKFYYFNLHMDHVGTVARREGAKLVVQRIKEIAKGKPVVLTGDFNVDQTNEIYGIFTQSGVLDDSFEKAQFRFAENGTFNSWDPELKTASRIDHVFVSPAFTVQRYGVLTNTYWSEAPQQTDTVKGADAPQEINFQKHQKRLPSDHYPVFVRLTF
>NC_014033.1|WP_013065717.1|1918208_1919771_+|DUF4957-domain-containing-protein
MKKIYLKSIVFGLATVALASCSDVADEITSIVYNRNFSPTSVEAKVRNRTNIELSWNLGDGVTNYNVEVYANDSLTFAGSPVQSFSVTPDQVPVLITGLDGETQYSFRVQATDGDATRDSKWSGVYAKTEAEQLFKNVKEEDIKAKEVTLRWTAGEEAATITLTPGNIVYNITAADIAAGAATVTGLTPETEYTAVMARANGKTRGKISFTTGVYLEETDILVKAGSNIAQAITDAPEGYRLIVEPGTYGIATDEAAFGGSVTVSKNLTIKGLRQNDHPVIKGRFKVEASLTIDQVTLDGKGTDGGQAFDFTAANTIDHFTVNNSEVTNYTKGFYYVNKAAKINSLVINNCLISNIECDGGDMFDCRAGAILMLNITNNTIWNSCKGRDLVRYDDKSGNFAGVAPVITIDHNTIVGACNDAGKRILYVRFKGNSITFTNNIVTASAGNFSNQKNTAEPTFENNFYSGADGYVTEGANANALFVDKSGTIADPQFKDAANGDFTVGNDAVKDNKAGDPRWF
>NC_014033.1|WP_013063502.1|1935882_1936632_+|polyprenol-monophosphomannose-synthase
MKQSDSIVIIPTYNEKENIEKIIRAIFGLEKSFHILVIDDGSPDGTAAIVRSLMSNEFGGQLHLVERSGKLGLGTAYIAGFKWALERDYEYIFEMDADFSHDPNDLPRLYAACKDEGYDVAIGSRYVSGVNVVNWPIGRVLMSYFASKYVRLVTGFNVHDTTAGFKCYKRRVLQTIELDKIRFKGYAFQIEMKYTAYKIGFKIKEVSVIFVNRQEGVSKMSGGIFGEAFFGVMKLRWDGWTRRYPKIEN
>NC_014033.1|WP_013064415.1|1936651_1937413_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MLKILYRIYQFIVCLPGIVLMTMITALEVGIGTTIGNGHFWGYMPGHIWGKIILKMFLIPVKVEGREHLEKNQSYVFVANHQGSFDIFLIYGHLNRNFKWMMKQALRKVPFLGYACEKSHQIFVDKRGPSKIRKTYNDAREILKEGYSVTVFPEGARSFTGHMGVFRKGAFALADELQLPVVPLTINGSFDILPRMKGFNFVNWHPMTLTIHEPIYPVGQGPENVEATLRQAYDSVMSALAPKYQGFVENPDQ
>NC_014033.1|WP_013064307.1|1937409_1938345_+|metallophosphoesterase
MIIIRFIIITVLFVIALTAVSIWAYKRRQKLVMAGAAVVWYIALYGTFIGFQKLEVNHQTYTSAELPKAFDGYKIVLFSDAHVGSYTGRNEWLLQRAVDSINAQKPDMIVFTGDLQNVDPQEIAEHLSTLSQLKAKDGVYSVLGNHDYDKYLLQKDGLDTQPCRETIALEKRMGWHLLQNENCTIKRGNDSLTIAGLDNDGDGKRFPQRGDVKKALQGATPFVIMLEHDPSGWRRKILPDGRAQLTLSGHTHNMQFALFGWAPMKLTGKEINGWYEEGSQSLFVTAGLGGLIPFRFGATGEIVVITLNIKH
>NC_014033.1|WP_013063100.1|1938355_1939171_-|5-methyltetrahydrofolate--homocysteine-methyltransferase
MKITYRISELVPYINWVYYYFAWQVKEEAEKQRMHAEALAKLQELDAQYQMHAVFELFDARSQDDDIEIYRTQLCPDCGVKHPVRVATIPCLRQQQGNPPFMCLADFISPKASKLGLFATTVDIGLETDFDGDVYQKMLTQLLADRLAEAAAERLHEQVRKEYWGYAKDENLSIEDMLVEKFQGIRPAVGYPSLPDTSLNFLLDEILDMKQIGIRLTESGAMKPHASVSGMMISNPKARYFAIGKIGEDQLQDYARRRAVPAEVLRKWLNV
>NC_014033.1|WP_013063137.1|1939167_1940499_-|dihydroorotase
MKRLILHGTLVNDANKFDGSVIVEDSKITKIVEGNTIPNASFDEVIDASGCFVLPGLIDDHVHFREPGLTAKADIDSESRAAAAGGVTTYFDMPNCVPQTTTLEALDEKFKLAAQKSHVNYSFFFGATNDNVDLFSQLDVHRIPGIKLFMGSSTGNMLVDRREALEKIFSTAQMPIMVHCEDTDIINRNMAEAKRLYGDDPKVTHHPEIRSVEACYQSTKLAVELALKHHAHLHIAHLTTAKELELIPHTPHPSPITCEVTPSHLYFCDRDYNALGTRIKCNPAIKSAADRDALRQAVADGRIAVIGTDHAPHLLEQKEGGCCKAASGMPMLQFSLVTMLELVDKGVLTIERLVELMCHRPADLFGVRNRGYLREGYQADIVIVRPNAAWTVTKDIIQSKCGWSPMENHTYLWRVEQTLCNGHTVYKDGVVDTNYIGQPVQFR
>NC_014033.1|WP_013063767.1|1940464_1941238_-|DUF4369-domain-containing-protein
MNKIFYALLTAVTFASCAESYNIQGSTSVSALDGSKLYLKTMVNDELKNLDSCDVVHGKFKFAGLLDTIKMASLYMDDEPLMMPVVIEQGDIEIHIDNTNRTVSGSPLNEKLYEFMKRHDQLGNELNELSHKQSQMLLEGIDENVINRQLSAEANRIAMQEDSLVTNFIVDNFDNVLGPGVFMMITGSYQYPILTPQIEDIMSKATKKFKADPYVKQYYQVANEIQARQNGLVEDVQPTPAPAQENNETPDSTRNAR
>NC_014033.1|WP_013063039.1|1941328_1941727_-|hypothetical-protein
MKELNKLQTAIFLFGGILMAVGAGTTLLGWGSAPYIFAIGALGFSSMQMQQRYEGQNFTIRRLRRMMLLSDVLFLVAALLMFASKGNFLGLSYITYIEYVYNKWVIVLLIAALLQLYSMHRIGSELEKEAKK
>NC_014033.1|WP_013065368.1|1941710_1942070_-|septum-formation-initiator-family-protein
MKVLLSIKAYALQVWRSVYFKYAVVCIVGVLLVGFLDDNSLWSHFKNRQRIAELTEEKDQFEADFNRDQAQIKELDRNPKAIEKIARERYFMKADDEDIFVLSDDDRDVKPLETNERVE
>NC_014033.1|WP_013064648.1|1942214_1944020_+|DNA-polymerase-III-subunit-gamma/tau
MEYIVSARKYRPLSFDTVVGQAALTTTLKNAVKSGKLAHAYLFCGPRGVGKTTCARIFAKAINCQHPTAEGEACNECESCQSFNEQRSLNIFELDAASNNSVEHIKTLMEQTRIPPQLGRYKVFIIDEVHMLSTAAFNAFLKTLEEPPAHVIFILATTEKHKILPTILSRCQIYDFERMTIRNTIDHLKHVAEQEGITYEEQALAVIAEKADGGMRDALSIFDQAASFCQGNITYEKVIEDLNVLDSENYFKIIDLAIDNKVSDIMVLLNGVINKGFDGGLLIQGLAKHVRNVLMARDPQTLPLLEVSDQMRARYEEQAKKCQITFLYDALKLMNQCDINYRQSSNKRLLVELTLIEIAQITQPAEDGASAGRKPRRLKSLFKNMIQQQKPKNAAPQVAAAKVAVSAAAAVTAEATGESQTAGTTASEASTTSNAKPKLSLGGIGFSWKKLRQQDNGPQKGGMQIIPGSINMPTGQDAVTDAQFTQTDLEFQWMAMCNRMPQKLSGIATRMKNMNPEITEFPTVEVVVDNELIKQEIEDIQKSIAKTLQVYLHNNQIQITVRVAEQTEHVKILSRREQFEQMAEKNAAVAKLQQAFDLELA
>NC_014033.1|WP_013063336.1|1944050_1944407_-|response-regulator
MKKILVAEDNDSNYVLMTYLLKKDFEFERAKNGQIAVEMVDANAYDLVLMDIKMPVMDGLQATRQIKEKHPELPVVALTANAFDSDRTAAEQAGCCGFLSKPVNRDECMALLKKLLGD

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014033_4	4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569366-1569395	30	NZ_CP040765	Paracoccus sp. 2251 plasmid unnamed1, complete sequence	266227-266256	5	0.833
NC_014033_4	4.10|1569564|29|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569564-1569592	29	NC_003905	Proteus vulgaris plasmid Rts1 DNA, complete sequence	100741-100769	5	0.828
NC_014033_4	4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT	1569892-1569920	29	NZ_CP049319	Caballeronia sp. SBC2 plasmid pSBC2-3, complete sequence	400086-400114	5	0.828
NC_014033_4	4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT	1569892-1569920	29	NZ_CP049159	Caballeronia sp. SBC1 plasmid pSBC1_3, complete sequence	44628-44656	5	0.828
NC_014033_4	4.19|1569892|26|NC_014033|PILER-CR	1569892-1569917	26	NC_015727	Cupriavidus necator N-1 plasmid pBB1, complete sequence	134568-134593	5	0.808
NC_014033_4	4.2|1569037|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569037-1569066	30	MK448837	Streptococcus phage Javan10, complete genome	7265-7294	6	0.8
NC_014033_4	4.2|1569037|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569037-1569066	30	JX409894	Streptococcus phage LYGO9, complete genome	38893-38922	6	0.8
NC_014033_4	4.3|1569103|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569103-1569132	30	NZ_CP040819	Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence	540848-540877	6	0.8
NC_014033_4	4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569366-1569395	30	NZ_CP021125	Rhizobium sp. Kim5 plasmid pRetKim5a, complete sequence	277441-277470	6	0.8
NC_014033_4	4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569366-1569395	30	CP007643	Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803b, complete sequence	342030-342059	6	0.8
NC_014033_4	4.10|1569564|29|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569564-1569592	29	MN693694	Marine virus AFVG_250M548, complete genome	18939-18967	6	0.793
NC_014033_4	4.2|1569037|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569037-1569066	30	NZ_CP047439	Spiroplasma citri strain BLH-MB plasmid pSciBLHMB-2, complete sequence	44305-44334	7	0.767
NC_014033_4	4.2|1569037|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569037-1569066	30	NZ_CP047440	Spiroplasma citri strain BLH-MB plasmid pSciBLHMB-3, complete sequence	69467-69496	7	0.767
NC_014033_4	4.2|1569037|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569037-1569066	30	BX571876	Leptospira biflexa temperate bacteriophage LE1	43180-43209	7	0.767
NC_014033_4	4.3|1569103|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569103-1569132	30	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	1116902-1116931	7	0.767
NC_014033_4	4.5|1569235|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569235-1569264	30	KJ019103	Synechococcus phage ACG-2014f isolate Syn7803US44, complete genome	33156-33185	7	0.767
NC_014033_4	4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT	1569892-1569920	29	NZ_CP045351	Vibrio sp. THAF100 plasmid pTHAF100_a, complete sequence	410994-411022	7	0.759
NC_014033_4	4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT	1569892-1569920	29	NZ_CP027296	Streptomyces sp. SGAir0924 plasmid unnamed_1, complete sequence	26270-26298	7	0.759
NC_014033_4	4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT	1569892-1569920	29	NZ_CP012182	Pseudonocardia sp. EC080610-09 plasmid pBCI2-1, complete sequence	699110-699138	7	0.759
NC_014033_4	4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT	1569892-1569920	29	NC_015727	Cupriavidus necator N-1 plasmid pBB1, complete sequence	134568-134596	7	0.759
NC_014033_4	4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT	1569892-1569920	29	NZ_CP012185	Pseudonocardia sp. EC080619-01 plasmid pBCI1-2, complete sequence	348297-348325	7	0.759
NC_014033_4	4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT	1569892-1569920	29	NC_010625	Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence	456219-456247	7	0.759
NC_014033_4	4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT	1569892-1569920	29	NC_010625	Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence	456231-456259	7	0.759
NC_014033_4	4.4|1569169|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569169-1569198	30	NZ_CP039845	Acetobacter pasteurianus strain CICC 22518 plasmid pAP22518-1, complete sequence	297887-297916	8	0.733
NC_014033_4	4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569366-1569395	30	MK308676	Vibrio phage vB_VmeM-Yong MS31, complete genome	181909-181938	8	0.733
NC_014033_4	4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569366-1569395	30	MK308675	Vibrio phage vB_VmeM-Yong XC32, complete genome	181908-181937	8	0.733
NC_014033_4	4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569366-1569395	30	MK308677	Vibrio phage vB_VmeM-Yong MS32, complete genome	181909-181938	8	0.733
NC_014033_4	4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569366-1569395	30	MK308674	Vibrio phage vB_VmeM-Yong XC31, complete genome	181908-181937	8	0.733
NC_014033_4	4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT	1569892-1569920	29	NZ_AP022611	Mycolicibacterium madagascariense strain JCM 13574 plasmid pJCM13574	4348-4376	8	0.724
NC_014033_4	4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT	1569892-1569920	29	NZ_AP022611	Mycolicibacterium madagascariense strain JCM 13574 plasmid pJCM13574	210865-210893	8	0.724
NC_014033_4	4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR	1569366-1569395	30	NC_009806	Kineococcus radiotolerans SRS30216 = ATCC BAA-149 plasmid pKRAD01, complete sequence	67249-67278	9	0.7
NC_014033_4	4.12|1569695|30|NC_014033|CRISPRCasFinder,CRT	1569695-1569724	30	NZ_CP029068	Enterococcus mundtii strain Pe103 plasmid pPe10302, complete sequence	3219-3248	9	0.7

1. spacer 4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP040765 (Paracoccus sp. 2251 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.833

cgccttgatggtgatgctgtcgt-gcagata	CRISPR spacer
cgccttgatggcgatgcagtcgtcgccggt-	Protospacer
***********.***** ***** ** *.* 

2. spacer 4.10|1569564|29|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to NC_003905 (Proteus vulgaris plasmid Rts1 DNA, complete sequence) position: , mismatch: 5, identity: 0.828

taaaggtt----agcaactccctccattttttt	CRISPR spacer
----gatttctgagcaactccctccattttttt	Protospacer
    *.**    *********************

3. spacer 4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT matches to NZ_CP049319 (Caballeronia sp. SBC2 plasmid pSBC2-3, complete sequence) position: , mismatch: 5, identity: 0.828

cagtcc--cagttgctcgcgcagttggtcgc	CRISPR spacer
--gcccgtcagttcctggcgcagttggtcgc	Protospacer
  *.**  ***** ** **************

4. spacer 4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT matches to NZ_CP049159 (Caballeronia sp. SBC1 plasmid pSBC1_3, complete sequence) position: , mismatch: 5, identity: 0.828

cagtcc--cagttgctcgcgcagttggtcgc	CRISPR spacer
--gcccgtcagttcctggcgcagttggtcgc	Protospacer
  *.**  ***** ** **************

5. spacer 4.19|1569892|26|NC_014033|PILER-CR matches to NC_015727 (Cupriavidus necator N-1 plasmid pBB1, complete sequence) position: , mismatch: 5, identity: 0.808

cagtcccagttgctcgcgcagttggt	CRISPR spacer
gagtccaaattgctcgcgcagttgac	Protospacer
 ***** *.***************..

6. spacer 4.2|1569037|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to MK448837 (Streptococcus phage Javan10, complete genome) position: , mismatch: 6, identity: 0.8

cagaatc-ccaaaagagcaaaaaagtaaaaa	CRISPR spacer
-agagttaacaaaagagcaaaaaattaaaag	Protospacer
 ***.*.  *************** *****.

7. spacer 4.2|1569037|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to JX409894 (Streptococcus phage LYGO9, complete genome) position: , mismatch: 6, identity: 0.8

cagaatc-ccaaaagagcaaaaaagtaaaaa	CRISPR spacer
-agagttaacaaaagagcaaaaaattaaaag	Protospacer
 ***.*.  *************** *****.

8. spacer 4.3|1569103|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP040819 (Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence) position: , mismatch: 6, identity: 0.8

gtggatggtgcgccagctgcaaggggacgg	CRISPR spacer
gaagatggtgcgccaaccgcaagggggcag	Protospacer
* .************.*.********.*.*

9. spacer 4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP021125 (Rhizobium sp. Kim5 plasmid pRetKim5a, complete sequence) position: , mismatch: 6, identity: 0.8

cgccttgatggtgatgctgtcgtgc-agata	CRISPR spacer
atccttgatggtgaggccgtcgtgctcgat-	Protospacer
  ************ **.*******  *** 

10. spacer 4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to CP007643 (Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803b, complete sequence) position: , mismatch: 6, identity: 0.8

cgccttgatggtgatgctgtcgtgc-agata	CRISPR spacer
atccttgatggtgaggccgtcgtgctcgat-	Protospacer
  ************ **.*******  *** 

11. spacer 4.10|1569564|29|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to MN693694 (Marine virus AFVG_250M548, complete genome) position: , mismatch: 6, identity: 0.793

taaaggttagcaactccctccattttttt	CRISPR spacer
ccaagtttagcaactccctctatttgtgt	Protospacer
. *** **************.**** * *

12. spacer 4.2|1569037|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP047439 (Spiroplasma citri strain BLH-MB plasmid pSciBLHMB-2, complete sequence) position: , mismatch: 7, identity: 0.767

cagaatc----ccaaaagagcaaaaaagtaaaaa	CRISPR spacer
----attgggggcaaaagagcaaaaaaggaaaaa	Protospacer
    **.     **************** *****

13. spacer 4.2|1569037|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP047440 (Spiroplasma citri strain BLH-MB plasmid pSciBLHMB-3, complete sequence) position: , mismatch: 7, identity: 0.767

cagaatc----ccaaaagagcaaaaaagtaaaaa	CRISPR spacer
----attgggggcaaaagagcaaaaaaggaaaaa	Protospacer
    **.     **************** *****

14. spacer 4.2|1569037|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to BX571876 (Leptospira biflexa temperate bacteriophage LE1) position: , mismatch: 7, identity: 0.767

cagaatcccaaaagagcaaaaaagtaaaaa	CRISPR spacer
gactatcctaatagagcaaaaaagtaaagg	Protospacer
 *  ****.** ****************..

15. spacer 4.3|1569103|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 7, identity: 0.767

gtggatggtgcgcc--agctgcaaggggacgg	CRISPR spacer
--tggtgacgtgcccgagctgcaaggggacgg	Protospacer
   *.**..*.***  ****************

16. spacer 4.5|1569235|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to KJ019103 (Synechococcus phage ACG-2014f isolate Syn7803US44, complete genome) position: , mismatch: 7, identity: 0.767

ataactataagaaagcccagaagggtggta	CRISPR spacer
aacactctaagaaagaccagaagggtcgcg	Protospacer
*  *** ******** ********** *..

17. spacer 4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT matches to NZ_CP045351 (Vibrio sp. THAF100 plasmid pTHAF100_a, complete sequence) position: , mismatch: 7, identity: 0.759

cagtcccagttgctcgcgcagttggtcgc	CRISPR spacer
tttcccaagttgctcgcgcagttcgtcgt	Protospacer
.  .** **************** ****.

18. spacer 4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT matches to NZ_CP027296 (Streptomyces sp. SGAir0924 plasmid unnamed_1, complete sequence) position: , mismatch: 7, identity: 0.759

cagtcccagttgctcgcgcagttggtcgc	CRISPR spacer
gataaccagttgctcgtgcaggtggtcgg	Protospacer
 *   ***********.**** ****** 

19. spacer 4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT matches to NZ_CP012182 (Pseudonocardia sp. EC080610-09 plasmid pBCI2-1, complete sequence) position: , mismatch: 7, identity: 0.759

cagtcccagttgctcgcgcagttggtcgc	CRISPR spacer
cttgcccagttgctcgcgcagtcgctcct	Protospacer
*   ******************.* ** .

20. spacer 4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT matches to NC_015727 (Cupriavidus necator N-1 plasmid pBB1, complete sequence) position: , mismatch: 7, identity: 0.759

cagtcccagttgctcgcgcagttggtcgc	CRISPR spacer
gagtccaaattgctcgcgcagttgactga	Protospacer
 ***** *.***************...* 

21. spacer 4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT matches to NZ_CP012185 (Pseudonocardia sp. EC080619-01 plasmid pBCI1-2, complete sequence) position: , mismatch: 7, identity: 0.759

cagtcccagttgctcgcgcagttggtcgc	CRISPR spacer
cttgcccagttgctcgcgcagtcgctcct	Protospacer
*   ******************.* ** .

22. spacer 4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT matches to NC_010625 (Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence) position: , mismatch: 7, identity: 0.759

cagtcccagttgctcgcgcagttggtcgc	CRISPR spacer
ctcggtcagttgatcgcgcagttgatcgc	Protospacer
*    .****** ***********.****

23. spacer 4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT matches to NC_010625 (Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence) position: , mismatch: 7, identity: 0.759

cagtcccagttgctcgcgcagttggtcgc	CRISPR spacer
atcgcgcagttgatcgcgcagttgatcgc	Protospacer
    * ****** ***********.****

24. spacer 4.4|1569169|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP039845 (Acetobacter pasteurianus strain CICC 22518 plasmid pAP22518-1, complete sequence) position: , mismatch: 8, identity: 0.733

cacgtgtcg-----gccacccttccacacgccctc	CRISPR spacer
-----gttagtaacgccacccttccacacgccatc	Protospacer
     **..     ****************** **

25. spacer 4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to MK308676 (Vibrio phage vB_VmeM-Yong MS31, complete genome) position: , mismatch: 8, identity: 0.733

cgccttgatggtgatgctgtcgtgcagata	CRISPR spacer
tgccttgatggtcatgctgtcggttacacg	Protospacer
.*********** *********  .* *..

26. spacer 4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to MK308675 (Vibrio phage vB_VmeM-Yong XC32, complete genome) position: , mismatch: 8, identity: 0.733

cgccttgatggtgatgctgtcgtgcagata	CRISPR spacer
tgccttgatggtcatgctgtcggttacacg	Protospacer
.*********** *********  .* *..

27. spacer 4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to MK308677 (Vibrio phage vB_VmeM-Yong MS32, complete genome) position: , mismatch: 8, identity: 0.733

cgccttgatggtgatgctgtcgtgcagata	CRISPR spacer
tgccttgatggtcatgctgtcggttacacg	Protospacer
.*********** *********  .* *..

28. spacer 4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to MK308674 (Vibrio phage vB_VmeM-Yong XC31, complete genome) position: , mismatch: 8, identity: 0.733

cgccttgatggtgatgctgtcgtgcagata	CRISPR spacer
tgccttgatggtcatgctgtcggttacacg	Protospacer
.*********** *********  .* *..

29. spacer 4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT matches to NZ_AP022611 (Mycolicibacterium madagascariense strain JCM 13574 plasmid pJCM13574) position: , mismatch: 8, identity: 0.724

cagtcccagttgctcgcgcagttggtcgc	CRISPR spacer
ggtgttcaggtgcgcgcgcagttggtcgc	Protospacer
 .  ..*** *** ***************

30. spacer 4.15|1569892|29|NC_014033|CRISPRCasFinder,CRT matches to NZ_AP022611 (Mycolicibacterium madagascariense strain JCM 13574 plasmid pJCM13574) position: , mismatch: 8, identity: 0.724

cagtcccagttgctcgcgcagttggtcgc	CRISPR spacer
ggtgttcaggtgcgcgcgcagttggtcgc	Protospacer
 .  ..*** *** ***************

31. spacer 4.7|1569366|30|NC_014033|CRISPRCasFinder,CRT,PILER-CR matches to NC_009806 (Kineococcus radiotolerans SRS30216 = ATCC BAA-149 plasmid pKRAD01, complete sequence) position: , mismatch: 9, identity: 0.7

cgccttgatggtgatgctgtcgtgcagata	CRISPR spacer
ggccttgatggtgatgccgtcgcgggcggc	Protospacer
 ****************.****.* . .  

32. spacer 4.12|1569695|30|NC_014033|CRISPRCasFinder,CRT matches to NZ_CP029068 (Enterococcus mundtii strain Pe103 plasmid pPe10302, complete sequence) position: , mismatch: 9, identity: 0.7

ctactacaaaaccctgcaatatcagtgcga	CRISPR spacer
ttacaacaaaaccttgcaatatcaaataat	Protospacer
.*** ********.**********.   . 

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	412021 : 418213	7	Klebsiella_virus(16.67%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_014033|412021:418213|DBSCAN-SWA
TTCATGTTAACTTTGATTTCTTGATTTCAAATCCTTGGGATACAATAAACTTCAGGGTGGCGAAGGCCGTATTTCGATCGTAGGCTTTCTCCTCCTCTGATAGTTCTTCATAGGGAACCAGACATGGAGTCTGTCGTTTCTCGTCGTCACGTACGGGGCCGTATGTCCAGCCTTCGTTCATGCGGTTCAGGGCCCATACCTCATGTACATTCTTTGAGATGGCCTCTGCAAGTACTGTTAGTTCTTCTGGCAGTTTCACGTTAGTAGTGTCAACTGGAGCAGGCTTGTAATCATAGTTTTTAGTCATAATACAATATCATTTGGCAAAATTAAACATTTGTGCTGAAATATACAAGCAAAATTGCATTTATTTGTTTTTCTTATATCTATAAGTTCGATAAAAAGCAATGGTTCCTTCCTGTACATGTGAATAATTGAATAGTTGAATATTTTTTATCAAATCCTTGGAAGTTTGATGAGAAACACCTATCTTTGCGGCACAAATGATAAATAGCATTTCAATAACTATAATGTAAAGCAAATGAGCTACACCTATAAATATCCACGTCCGGCAGTTACTGCCGACATGATTGTTCTGGCAGATAAGTCGGAACCTAAAATACTATTGATTCAACGTAGAGATGAACCCTTCAAAGGCTGTTGGGCATTTCCTGGCGGTTTTATGGATATGGATGAGACTACTGAACAATGCGCTATTCGCGAACTCAAGGAGGAAACAGGCCTTGAGGTAGGGGAGGTAAAACAAGTAGGCGCCTATTCATCAGTCGACCGCGATCCACGTGGTCGCACCATCACTGTGGCTTACGTTGCTCACATACCTCAGGCACTTCCTGTTATGGGGCTCGACGATGCTGCCGAAGCCAAGTGGTGGCCTATTGATGCACTTCCACCACTGGCCTTCGATCATGCACAGATACTGCAAGATGCTTTAAAGGGATAATCATTTTTTTATCTTTATGTGCTCTTTGCTGATAACGCCATCGCGTACCAGTTCGATGATGTCATTTTCGGTCAGGCATCCATGGCAGAACAAGTGGAGGGCAGCTACCCCCCAGTCTATAAATGGAGATGCATCGCTGTCATCTGTTTTTAGAGGTGCGCCGAGCGCTGCGTCATCAATGTATATGTTACCATATACTTTTGGTGATGAAGTCCAATCCTTCTGGCTGGGATTCTCATTCACACCATATAGTGGAATGTCACGTTCCTTAAACCAATCGAGTGCGGGCTGGAGTGTGTCTACGCCTTCAGAATCATGACTTCTCATGGTGCTCAACAGTAGTTTATGCCCATTGTTTACCAATTTCCTTAATACTGGTACTGATCCTATATCTTCTCCGACGGCAGGGTAGCGATGCTTCACTACCGTACCGTCGAAGTCGAGTACTATGTAATAACTGTATTGAATCATTTAGTCAAGTTTAATGTTCTCACATCCGGGGAAGAGGTTGAGGAAAGCCTGAGCATTAACAGGCCTTTCGTTTACGAATTGATAAAGGCCTTCAGCTATCGCCTCCTTCATTAGATCAGTACACTCAAGCATATCAAACATTATGTATTTATCAGCATCCACGGTAATAGGTTTTGGAAGTTTTCCAGATAACATAGTGAATAATGTCGCAGCCACACTGTAGATGTCTGACTGGGGGCAGAAGTGCTTCATCGTACCTCTGGTGTTTTCTGGAGCCGAGAATCTGTCGTAGGAGTGTATATCTCCTCTTATTTCTGTGATATCCCCATTATCGTCATATTGCTGTGATACTCCAAAGTCGATGAGCACAGCCTCGCCATTCTCGTCTATAACAATATTGTCTGGTTTGATGTCTAGATGTAGAATCCTGTGACTGTGCATAGCATGGAGAGCTTTACACAATGGGATGACGATCTTGTCTATAATCAGTTTCTCAGATGATGGAACTTGATCGTTGATTATCATGTCTTTGAGCGACTCTCCTGCATAGAATTTCATTACGTAATATGTAGTGCCAGTAGCTTCATATTCAAATAATGACTTAACTTCTGTTACATGATTGTCAGCTATGTCGGCCATGCTAAGAAGGAATACAGGTTCACTACGGAACATTTTTCGCAGCGATTCAAACTCTGCCTCAAGTGTTTCATCGTACATTACTCTGCATGTCTTCTCGTTTTCTCGATAACATGTGAGATCCCCAATTCCTCTTGGATAGAACTCCTTAATAGCAACGATTTCCTTCGAACCATTACTGCAATTAAGCATCTCTGCGCGATAGGTATAGCCAAATGCACCGCAAGAGATATAGTTTAAGATGGTGTATCTCTTGTTGTCATCTGTTAATTCGAATCCAGGAGGCAGGGCATCAGCTCCTTCTTCTTGTATTTGTGCAGGTGCTTCAGCATTCTCTACGTCTGGCAGATCAAAATCTTCTACCTCTATATATAATATAAGGTTTAGGTAATCTTCTTCTGTCAATGGTTCTGGCACCATTTCATTTTGGCCATAGGGATGAAGTTGACGCCTTACATACGATTGGCTTAACTCGTCTGCAAGCCATTGTGGGTTTTCAAATCCATTAAGTGCAAATGCATAACCATCTTCAAAGAATGCTGATCCTATATCCGCATTGAAAAGTCTGGGCTCAGCAGGTCCTGAAGCATTAACTATTAAGCAGTCTTCGTCTAGGTAATAAGCCGGATTGAATAAGTTCTTGATAGGTCTTCTTTCAATATTCTCATCCCATCGATTACCATAATAGGTCTCGTTCCGGTTTATATAGGCCAGAATATGCTCATCTTCATCTATATTGTCAAGGTTATAAACCGCACGTGGTATCTTTGAGACAATATCACCTAACCTAACTTTTCCAAATCCTTTGCGATCAGGCAGTTCTGATACGATAAGAGATTTGAGATACCCCTTTTTCTTGGCATTGCTAACCTTGATATATTCTGAGAACATATCATCCTCGATGAGTTCCTGCATAGATGTATGCTGGGCCAGTGGGTTCGTGCCATCTATAAACCGAATGAGTCCTTTAAAAACAGTGGTTTTCTGGGCATTTATCAATACGGCTACTTCTCCGAAGGGAAGCAAGGCGATGGTTTCAATCCAGTCGCGCTTCAGGGCTTCCTTAAAGTTTGCCGTCTCTTTCTCGAAGATCTCCTTCGGTAATACCATACCTGCATAGCGACCTTTGAAGTCTGGATCATTCAAACATTTGCCTAGGCAAAAATCGAAGGCTGACTCGCCATTGATGAATCCGGTATATGTGGTGATAACATAGTCAATCTGCTTGCCGTTGAGCCATTGAGTAGAATCGCGCTGCAGGAAGTGCTCGTTTGATACCCCCATGCCGTAGTTCAGCAATAGTCCACCTGCATAAATCTTGTCATTGGTATCACCATCACCAAAGTAATTGGTTTTTGATTGCAACATCGCACCTGCGATAGGACAACCGGCAAACGGGTTGTACACCAGTCCTTTGCCATCATATTGTAATAGCGCTTTCAGGGCATGGGCCACTCTCAAACGTGGACGCTTAGGTTGTATACCGGATTTATTCCAAATATGATTGAAGATGTTCAGATACCTATCTTTTATATACGAAACTGGTGTGTTAAGCAGGGCTTCGGCTAGAACGAATGTTGCATACTGGCGCTGTGCTTTCTCGCTGGCTTCGTTGCTCGAATGATGCACCAGACGTCCTATCCTGTGATGATATTCGCGAACCACGTCTCGTTCATCGTTGTTCTTCAGAGTCGTATAAATCTGAAGCAGGCTGCGGCCAATCTCCATTTCCACTGCAATAGATGTTATTCCATCCTTAATCCATTTATTGACTCTTCGCTTCAGAGTCGCATCAAGATCCACCCACTCATAGTCGATAATTTCTTTGGGGTTGAGCACACATGCTGCAGTCTCAGGTTTGCTGTTTCCTGTAGCAATTCTTAGTTTTCCATTTGCAGCCAATGCCACCATCATCAGCGGCATAAGCGTGTCTGGATTGTAGTGGTAGTAGTTTTCCACTGCATCAAAAAGTCTACTGGAGAATTCCTTTTTTGCCATAGGTCTTAGATATTAATGTAGAGTATAATACTTATTTTCCTGCAAATATATGCAATTCCTGTCTTTTTCCAAAGGAAAATCAAAAAAAGTTGCTATAATGTGTTAGATATTTCCTTTTTCGTGTACTATTATTATATACGAATTATTTATCTAAACCCGTTTTATATATGGCAAATCTATTAGCAATCAGCATTCCTGTTAAGCGCGATCCTTCCTGGTCCGACTGGGCCAAGCGCACTCGTGCTAGTATCAAGGCTGCAGGTGTTCCTGTCAGCAGGTGGCAATTGTTGTTTTACCACATGACTATCCTATTCATCGACGAAGACGCCTGTGTCGCCGACCTCACACCCGGCTTCGCTCAGGTCTTGAAATCATGTCCTGCCATACCGTTTATTGTCAATAAACTCGATGCCTTCACCACCACTAATGGTGCCGAACACATCATCTGTCTGTTGTCTACTCAGGTGCCACAGCAGATCCACAACCTTGCCAGCGACTCAAGGACGATGGCCGACGGCCTCAATGCCAAATACGATCATCGTCCATTCATCCCCCATATCACCTTTGGACATGTGCCAGCCGACAAAATCTCGCTCCAGGAGTTGCGCACCATTCTTGAGGCTCTGCCACAGCCCTCATTCCATTGCCTTCTCAACGAGGCCGAACATCGCTATCGCCGCGGCAACGGCACCATCAAGAAATGGCGCCTCCGCTGATAGTGCACTTTTTCCTCTCAAATACTTGCAAGTTTGAGAGAAAATGTTTATCTTTGCAATATCAATAATAACTAAAAACAATTGTAATTATGAATAAGTCGGATTATAGAAAGATTAACCGTGAAGTGATGACCGACACTAAACTCCAGTATGAAACAATACCAGAGTTGAAGGAGGCCGTGGAGAACTCGATTGAGCGACAGTATATGGTATCCCAAGAGGATAACATTGACCAACCAGTAGTCGACAGCAGCCATACCAAGTATCTCTGCTCTGGCAAGAGAAGCTTTGAGGCAGCTAAGGATTACAAGGGCAAGAAGGTTGCTGTGCTGAATTTCGCTAACAACCACACGATTGGAGGTGCACCATTCTCTGCAGGTGCCCAAGAGGAGTCGCTCTGCAGATGCTCTACATTGCTACCTTGCCTTGAAGCCATGAGCGAACCCTTCTACCAGAAGCATATTCGCCAATTCGAGTCAGGAGAGATTAACTATATGGGTAATGATGACTTGATCTACACCCCTGATGTGGTGGTCTTTAAAACAGATGAGCGCACTGACCCTATCTATCCTAAGATGATGGATCGAAGCGAATGGTATAAGGTGGATGTAATTACAAGTGCAGCTCCGCAGTTGAGGAGAGTTCGCACACTCCCCGTCAACTACAATGACGTAATCTTTGGCCGCATTAAGAAGATATTGGATGTGGCTGCCAAAGAGCATGTCGAAGTGCTGATTCTGGGAGCATGGGGCTGTGGAGCCTTCAAGAATGATGCAAAAGTAGTATCGGATACATTCTATACATTACTGAAGAATTACAACTTCGAGGTAGTAGAATTTGCACTGTCTGACCCTGCCTACGTCACCAATTCCCCATTTAATAAGTGTAATAGTTAATCCAAATTTCTAGTATGAGAGTTACAGATAAACATATTTGTTTCTGGAATGAATGGCCCAGCAATTGGCATCCAGCCGAGTTTGATGTTGAAGTTAATGGTGTGAAATGTCATTTCTACAACACCGAACAGTACTTTATGTATATGAAGGCCATCGTGTTTGGCGATGAAGAAATTGCCAAACAGATATTGGAGGTAAGCGACCCCAAGAAGGTAAAAGCACTTGGACGTAAGGTACAGAATTATGATGAGGCTGTATGGAACGAAAAGCGCTACCAGGTCATGCTTAAAGCCAACGTAGCAAAGTTCAGCCAGAACGAAGATCTAAAGCAATTGCTTCTCTCTCCAGAGTACGAAGGACATGGATTCGTAGAGGCCTCGCCTTATGATAAAGTCTGGGGTGTGCGAATGTTTGAGAGTAATCCCGACATTGATGACGAAACCAAATGGAAGGGACTCAACCTCCTGGGTAAAGTCCTCGACGAAACCCGCCGAATTGTAAGCCTATTAAAATAG

Protein sequences of DBSCAN-SWA_1

>NC_014033|412021:418213|412021_412327_-|WP_041385528.1|DBSCAN-SWA
MTKNYDYKPAPVDTTNVKLPEELTVLAEAISKNVHEVWALNRMNEGWTYGPVRDDEKRQTPCLVPYEELSEEEKAYDRNTAFATLKFIVSQGFEIKKSKLT
>NC_014033|412021:418213|417712_418213_+|WP_013065416.1|DBSCAN-SWA
MRVTDKHICFWNEWPSNWHPAEFDVEVNGVKCHFYNTEQYFMYMKAIVFGDEEIAKQILEVSDPKKVKALGRKVQNYDEAVWNEKRYQVMLKANVAKFSQNEDLKQLLLSPEYEGHGFVEASPYDKVWGVRMFESNPDIDDETKWKGLNLLGKVLDETRRIVSLLK
>NC_014033|412021:418213|416253_416802_+|WP_080517157.1|DBSCAN-SWA
MANLLAISIPVKRDPSWSDWAKRTRASIKAAGVPVSRWQLLFYHMTILFIDEDACVADLTPGFAQVLKSCPAIPFIVNKLDAFTTTNGAEHIICLLSTQVPQQIHNLASDSRTMADGLNAKYDHRPFIPHITFGHVPADKISLQELRTILEALPQPSFHCLLNEAEHRYRRGNGTIKKWRLR
>NC_014033|412021:418213|412981_413452_-|WP_013065177.1|DBSCAN-SWA
MIQYSYYIVLDFDGTVVKHRYPAVGEDIGSVPVLRKLVNNGHKLLLSTMRSHDSEGVDTLQPALDWFKERDIPLYGVNENPSQKDWTSSPKVYGNIYIDDAALGAPLKTDDSDASPFIDWGVAALHLFCHGCLTENDIIELVRDGVISKEHIKIKK
>NC_014033|412021:418213|412561_412981_+|WP_013065575.1|DBSCAN-SWA
MSYTYKYPRPAVTADMIVLADKSEPKILLIQRRDEPFKGCWAFPGGFMDMDETTEQCAIRELKEETGLEVGEVKQVGAYSSVDRDPRGRTITVAYVAHIPQALPVMGLDDAAEAKWWPIDALPPLAFDHAQILQDALKG
>NC_014033|412021:418213|416891_417698_+|WP_049769055.1|DBSCAN-SWA
MNKSDYRKINREVMTDTKLQYETIPELKEAVENSIERQYMVSQEDNIDQPVVDSSHTKYLCSGKRSFEAAKDYKGKKVAVLNFANNHTIGGAPFSAGAQEESLCRCSTLLPCLEAMSEPFYQKHIRQFESGEINYMGNDDLIYTPDVVVFKTDERTDPIYPKMMDRSEWYKVDVITSAAPQLRRVRTLPVNYNDVIFGRIKKILDVAAKEHVEVLILGAWGCGAFKNDAKVVSDTFYTLLKNYNFEVVEFALSDPAYVTNSPFNKCNS
>NC_014033|412021:418213|413452_416086_-|WP_013063600.1|DBSCAN-SWA
MAKKEFSSRLFDAVENYYHYNPDTLMPLMMVALAANGKLRIATGNSKPETAACVLNPKEIIDYEWVDLDATLKRRVNKWIKDGITSIAVEMEIGRSLLQIYTTLKNNDERDVVREYHHRIGRLVHHSSNEASEKAQRQYATFVLAEALLNTPVSYIKDRYLNIFNHIWNKSGIQPKRPRLRVAHALKALLQYDGKGLVYNPFAGCPIAGAMLQSKTNYFGDGDTNDKIYAGGLLLNYGMGVSNEHFLQRDSTQWLNGKQIDYVITTYTGFINGESAFDFCLGKCLNDPDFKGRYAGMVLPKEIFEKETANFKEALKRDWIETIALLPFGEVAVLINAQKTTVFKGLIRFIDGTNPLAQHTSMQELIEDDMFSEYIKVSNAKKKGYLKSLIVSELPDRKGFGKVRLGDIVSKIPRAVYNLDNIDEDEHILAYINRNETYYGNRWDENIERRPIKNLFNPAYYLDEDCLIVNASGPAEPRLFNADIGSAFFEDGYAFALNGFENPQWLADELSQSYVRRQLHPYGQNEMVPEPLTEEDYLNLILYIEVEDFDLPDVENAEAPAQIQEEGADALPPGFELTDDNKRYTILNYISCGAFGYTYRAEMLNCSNGSKEIVAIKEFYPRGIGDLTCYRENEKTCRVMYDETLEAEFESLRKMFRSEPVFLLSMADIADNHVTEVKSLFEYEATGTTYYVMKFYAGESLKDMIINDQVPSSEKLIIDKIVIPLCKALHAMHSHRILHLDIKPDNIVIDENGEAVLIDFGVSQQYDDNGDITEIRGDIHSYDRFSAPENTRGTMKHFCPQSDIYSVAATLFTMLSGKLPKPITVDADKYIMFDMLECTDLMKEAIAEGLYQFVNERPVNAQAFLNLFPGCENIKLD

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041385528.1|412021_412327_-	Ryanodine receptor Ryr	A0A2K9VAS7	Klebsiella_virus	3.9e-06	46.5
WP_013065575.1|412561_412981_+	NUDIX hydrolase	A0A0E3JJF3	Streptomyces_phage	1.7e-23	42.2
WP_013065177.1|412981_413452_-	hypothetical protein	A0A1W6DYI0	Aeromonas_phage	1.4e-34	56.3
WP_013063600.1|413452_416086_-	protein kinase	F2WL08	Lausannevirus	2.1e-07	23.5
WP_080517157.1|416253_416802_+	2'-5' RNA ligase family protein	NA	NA	NA	NA
WP_049769055.1|416891_417698_+	TIGR02452 family protein	A0A2H4UVH6	Bodo_saltans_virus	3.7e-11	31.5
WP_013065416.1|417712_418213_+	NADAR family protein	A0A1S6UAJ7	Serratia_phage	2.3e-35	49.1