CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NC_013264	Erwinia pyrifoliae Ep1/96 plasmid pEP03, complete sequence	0 crisprs	NA	0	0
NC_013265	Erwinia pyrifoliae Ep1/96 plasmid pEP05, complete sequence	0 crisprs	NA	0	0
NC_013263	Erwinia pyrifoliae Ep1/96 plasmid pEP36, complete sequence	0 crisprs	NA	0	4
NC_013954	Erwinia pyrifoliae Ep1/96 plasmid pEP2.6, complete sequence	0 crisprs	NA	0	0
NC_012214	Erwinia pyrifoliae Ep1/96, complete genome	8 crisprs	DEDDh,cas3,cas8e,cse2gr11,cas7,cas5,cas6e,cas1,cas2,cas3f,cas8f,cas5f,cas7f,cas6f,DinG	26	8

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 5481

Enterobacteria_phage(66.67%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012814633.1\|748_1330_-	recombinase family protein	Q1MVP4	Enterobacteria_phage	1.6e-40	47.8
WP_012814634.1\|1490_4487_+\|transposase	Tn3 family transposase	Q1MVP5	Enterobacteria_phage	0.0e+00	63.9
WP_011078067.1\|4500_5481_+	methionine ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.4e-25	35.5

DBSCAN-SWA_2

8611 : 12597

Vibrio_phage(50.0%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011114006.1\|8611_10642_+\|holin	choline transporter	A0A2I7QNT1	Vibrio_phage	4.9e-20	28.8
WP_041473951.1\|11026_11686_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_012814636.1\|12012_12597_-	recombinase family protein	A0A219YA40	Aeromonas_phage	6.1e-24	35.5

DBSCAN-SWA_3

16637 : 20425

uncultured_Caudovirales_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011078058.1\|16637_16925_+	type II toxin-antitoxin system RelE/ParE family toxin	A0A2H4JBF4	uncultured_Caudovirales_phage	5.5e-18	51.1
WP_011078079.1\|17084_17369_+	DUF2132 domain-containing protein	NA	NA	NA	NA
WP_041473956.1\|17632_17947_+	toxin RelE	NA	NA	NA	NA
WP_011113999.1\|17947_18361_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_041473953.1\|18868_20425_+	cellobiose phosphorylase	A0A2H4J162	uncultured_Caudovirales_phage	2.7e-10	30.4

DBSCAN-SWA_4

26624 : 31761

uncultured_virus(25.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012814645.1\|26624_27833_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.2e-50	49.2
WP_014539990.1\|28083_28425_-\|transposase	transposase	Q9ZXG3	Shigella_phage	7.4e-06	78.6
WP_011078049.1\|28702_29680_-	replication initiation protein	A0A222YYK1	Escherichia_phage	7.8e-24	28.9
WP_014540014.1\|30925_31138_-	chromosome partitioning protein ParB	NA	NA	NA	NA
WP_011078071.1\|31134_31761_-	AAA family ATPase	D4HTX7	Vibrio_phage	5.7e-28	36.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_012214

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CRISPR-Cas detection and classification

Crispr_ID: NC_012214_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012214_1

778089-778170

Orphan

Consensus_repeat	Method
GCGGTGGTTCATCGGGCAGCGGCAGTGGTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012214_1

>merge|NC_012214|1|778089-778170|CRISPRCasFinder
GCGGTGGTTCATCGGGCAGCGGCAGTGGTTCAGGCTCCGGTGGCTCCTCGGGTGGTGGTGCCTCATCGGGCAGCGGTGGTTC

>NC_012214|1|1|778089-778170|CRISPRCasFinder
GCGGTGGTTCATCGGGCAGCGGCAGTGGTTC	AGGCTCCGGTGGCTCCTCGG
GTGGTGGTGCCTCATCGGGCAGCGGTGGTTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012214.1\|WP_012667023.1\|771688_773023_+\|type-II-toxin-antitoxin-system-HipA-family-toxin-YjjJ	unknown	unknown	gnl\|CDD\|236623
NC_012214.1\|WP_012667035.1\|786560_786926_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_014538579.1\|789872_790205_+\|trp-operon-repressor	unknown	unknown	gnl\|CDD\|179289
NC_012214.1\|WP_012667024.1\|773052_773712_-\|YtjB-family-periplasmic-protein	unknown	unknown	gnl\|CDD\|236885
NC_012214.1\|WP_012667021.1\|769525_770749_+\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
NC_012214.1\|WP_012667020.1\|768139_769462_+\|thymidine-phosphorylase	unknown	unknown	gnl\|CDD\|180276
NC_012214.1\|WP_012667026.1\|774861_776244_+\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|273067
NC_012214.1\|WP_012667029.1\|779199_780939_+\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	unknown	unknown	gnl\|CDD\|225387
NC_012214.1\|WP_012667025.1\|773874_774852_+\|phosphoserine-phosphatase	unknown	unknown	gnl\|CDD\|182988
NC_012214.1\|WP_012667030.1\|781033_782035_-\|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|176214
NC_012214.1\|WP_012667037.1\|790190_790739_-\|inosine/xanthosine-triphosphatase	unknown	unknown	gnl\|CDD\|235336
NC_012214.1\|WP_012667038.1\|790789_791437_+\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase-GpmB	unknown	unknown	gnl\|CDD\|179583
NC_012214.1\|WP_012667032.1\|783078_784746_-\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NC_012214.1\|WP_012667022.1\|770821_771541_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_012214.1\|WP_014538578.1\|787863_789786_+\|murein-transglycosylase	unknown	unknown	gnl\|CDD\|183236
NC_012214.1\|WP_012667027.1\|776292_777519_+\|multifunctional-transcriptional-regulator/nicotinamide-nucleotide-adenylyltransferase/ribosylnicotinamide-kinase-NadR	unknown	unknown	gnl\|CDD\|236151
NC_012214.1\|WP_012667019.1\|767226_768006_+\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|235387
NC_012214.1\|WP_012667034.1\|785235_786321_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|224113
NC_012214.1\|WP_041473972.1\|782132_783014_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NC_012214.1\|WP_012667018.1\|766182_766959_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|171118

Protein	Function_ID	Function_description	E-value
NC_012214.1\|WP_012667023.1\|771688_773023_+\|type-II-toxin-antitoxin-system-HipA-family-toxin-YjjJ	gnl\|CDD\|236623	PRK09775, PRK09775, type II toxin-antitoxin system HipA family toxin YjjJ.	0
NC_012214.1\|WP_014538578.1\|787863_789786_+\|murein-transglycosylase	gnl\|CDD\|183236	PRK11619, PRK11619, lytic murein transglycosylase; Provisional.	0
NC_012214.1\|WP_014538579.1\|789872_790205_+\|trp-operon-repressor	gnl\|CDD\|179289	PRK01381, PRK01381, trp operon repressor.	6.88705e-50
NC_012214.1\|WP_012667024.1\|773052_773712_-\|YtjB-family-periplasmic-protein	gnl\|CDD\|236885	PRK11246, PRK11246, YtjB family periplasmic protein.	1.12318e-149
NC_012214.1\|WP_012667021.1\|769525_770749_+\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
NC_012214.1\|WP_012667020.1\|768139_769462_+\|thymidine-phosphorylase	gnl\|CDD\|180276	PRK05820, deoA, thymidine phosphorylase; Reviewed.	0
NC_012214.1\|WP_012667026.1\|774861_776244_+\|DNA-repair-protein-RadA	gnl\|CDD\|273067	TIGR00416, DNA_repair_protein_RadA_homolog, DNA repair protein RadA. The gene protuct codes for a probable ATP-dependent protease involved in both DNA repair and degradation of proteins, peptides, glycopeptides. Also known as sms. Residues 11-28 of the SEED alignment contain a putative Zn binding domain. Residues 110-117 of the seed contain a putative ATP binding site both documented in Haemophilus (SP:P45266) and in Listeria monocytogenes (SP:Q48761) . for E.coli see ( J. BACTERIOL. 178:5045-5048(1996)). [DNA metabolism, DNA replication, recombination, and repair].	0
NC_012214.1\|WP_012667029.1\|779199_780939_+\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	gnl\|CDD\|225387	COG2831, FhaC, Hemolysin activation/secretion protein [Intracellular trafficking and secretion].	5.82755e-49
NC_012214.1\|WP_012667025.1\|773874_774852_+\|phosphoserine-phosphatase	gnl\|CDD\|182988	PRK11133, serB, phosphoserine phosphatase; Provisional.	0
NC_012214.1\|WP_012667030.1\|781033_782035_-\|zinc-binding-alcohol-dehydrogenase-family-protein	gnl\|CDD\|176214	cd08252, AL_MDR, Arginate lyase and other MDR family members. This group contains a structure identified as an arginate lyase. Other members are identified quinone reductases, alginate lyases, and other proteins related to the zinc-dependent dehydrogenases/reductases. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
NC_012214.1\|WP_012667037.1\|790190_790739_-\|inosine/xanthosine-triphosphatase	gnl\|CDD\|235336	PRK05074, PRK05074, non-canonical purine NTP phosphatase.	1.07413e-117
NC_012214.1\|WP_012667038.1\|790789_791437_+\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase-GpmB	gnl\|CDD\|179583	PRK03482, PRK03482, phosphoglycerate mutase GpmB.	1.2748e-150
NC_012214.1\|WP_012667032.1\|783078_784746_-\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NC_012214.1\|WP_012667022.1\|770821_771541_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	4.73496e-172
NC_012214.1\|WP_012667027.1\|776292_777519_+\|multifunctional-transcriptional-regulator/nicotinamide-nucleotide-adenylyltransferase/ribosylnicotinamide-kinase-NadR	gnl\|CDD\|236151	PRK08099, PRK08099, multifunctional transcriptional regulator/nicotinamide-nucleotide adenylyltransferase/ribosylnicotinamide kinase NadR.	0
NC_012214.1\|WP_012667019.1\|767226_768006_+\|deoxyribose-phosphate-aldolase	gnl\|CDD\|235387	PRK05283, PRK05283, deoxyribose-phosphate aldolase; Provisional.	1.23523e-178
NC_012214.1\|WP_012667034.1\|785235_786321_-\|ParA-family-protein	gnl\|CDD\|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	1.59645e-16
NC_012214.1\|WP_041473972.1\|782132_783014_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.22712e-61
NC_012214.1\|WP_012667018.1\|766182_766959_+\|metal-dependent-hydrolase	gnl\|CDD\|171118	PRK11449, PRK11449, metal-dependent hydrolase.	2.0911e-122

>NC_012214.1|WP_012667027.1|776292_777519_+|multifunctional-transcriptional-regulator/nicotinamide-nucleotide-adenylyltransferase/ribosylnicotinamide-kinase-NadR
MSSFDYLKTAIRQQGCTLQQVADASGMTKGYLSQLLNAKIKSPSAQKLEALHRFLGLEFPRREKSIGVVVGKFYPLHTGHIYLIQRACSQVDELHIIMGYDEPRDRKLFEESAMSQQPTVSDRLRWLLQTFKYQKNIHIHSFNEQGMEPYPHGWDVWSAGIQEFMADRGIIPDLIYTSEEADAPQFRTHLGVEAVLIDPKRSFMNISGGQIRQDPFHYWEYIPTEVKPFFVRTVAILGGESSGKSTLVNKLANIFNTTSAWEFGRDYVFSHLGGDEMALQYSDYDKIALGQAQYIDFAVKYANKVAFIDTDFVTTQAFCKKYEGREHPFVQALIDEYRFDLVILVENNVPWVADGLRSLGSSVDRKEFQALLMSLLEENNISYVQVKQDNYDERFLRCVELVKEMLGA
>NC_012214.1|WP_012667026.1|774861_776244_+|DNA-repair-protein-RadA
MAKAVKRAFVCNECGADYPRWQGQCSACHAWNTITEVRLAASPTVARNERLTGYAGSAGPSRVQKLSEISLDELPRFSTGFKEFDRVLGGGVVPGSAILIGGNPGAGKSTLLLQTLCRLAEGMKTLYVTGEESLQQVAMRAHRLGLPTANLNMLSETSIEQICLIAEQEQPKLMVIDSIQVMHMADIQSSPGSVAQVRETAAYLTRFAKTKGVAIVMVGHVTKDGSLAGPKVLEHCIDCSVLLDGDADSRFRTLRSHKNRFGAVNELGVFAMTEQGLREVSNPSAIFLSRGDEITSGSSVMVLWEGTRPLLVEIQALVDHSMMGNPRRVAVGLEQNRLAILLAVLHRHGGLQMADQDVFVNVVGGVKVTETSADLALMLSMVSSLRDRPLPHDLVVFGEVGLAGEIRPVPSGQERISEAAKHGFRRAIVPTANVPKKPPENMKVYGVKKLADALAILDDL
>NC_012214.1|WP_012667025.1|773874_774852_+|phosphoserine-phosphatase
MPNSLTWCDLPAEVSLWPGLPLSLSGDEVMPLDYRAGRSGWLLYGRQLDKARLTALQHQLGAAMVIVSAWGVEDYQVVRLAGSLTPLATRLAHDAGLDVAPLGRIPHLKTPGLLVMDMDSTAIEIECIDEIAKLAGSGEQVAEVTERAMRGELDFAASLRQRVATLKGADANILKTVRDELPLMPGLTSLVQKLQALGWQVAIASGGFTWFAEYLRDTLQLSAAVANELEIRDGKLTGEVVGDIVDAQYKADTLRKLATRFAISPQQTVAVGDGANDLPMIKASALGIAYHAKPKVNQQSEFIIRHADLMGVFCILSGSLIHEER
>NC_012214.1|WP_012667024.1|773052_773712_-|YtjB-family-periplasmic-protein
MAKAKIKFRLHRTAIVLICLALLVVLMQGASWFSLSHQAARSEQVEELAHTLTRQVAWSLTPLMDNTDDNQQKIVDTLNQLTHESRILDISLYDGAGNLVARSGENINVRDRLALDGQRAGSYFNHQIVQPLESKDGPGGFLRVTLDTHVLVTEAKQVDNTTNILRLMMLLALAIGIILTRTLLRDRRTRWQQSPFLLTANNPVKEDNEDDLPSATSEK
>NC_012214.1|WP_012667023.1|771688_773023_+|type-II-toxin-antitoxin-system-HipA-family-toxin-YjjJ
MSELTTLLLQGPLDAASLQARLGISQATLSRLIKSQPQVLKYGRARATRYALLRPLREVSQFPLWQIDITGQAHAAGQLYSIWPAGSCVVQDASASWHYYPGLPWYLSDMRPQGFLGRAWGRDCAQQLALPEDIRQWNDDHCLLALSSRGADVTGSWLIGQHSYQQWLQQPRPAAAVMLADKATCYPQLASQVLAGEQPGSSAGGEQPKFASLAELADGSLAHVLVKFTPARANENSQRWCDLLRAEALALRLMQQHGLAAAQTAAIAADSGQLFLEVVRFDRTGENGRRSMVSLEAVQAEFIGNSHHWPAALRQLVQQKRLSERDAQRGILQWAFGRLIANGDMHAGNLSFFLTEGGLRLTPAYDMLPMSFAPNSAGYMRDSAVELRLDDSVSQHQWQTALEMAGQYWQSISAESAFSAGFRQLATEMQRNLPGLAGQIARMA
>NC_012214.1|WP_012667022.1|770821_771541_+|purine-nucleoside-phosphorylase
MATPHINAEMGDFADVVLMPGDPLRAKHIAETFLQDAVEVNNVRGMLGYTGTYKGRKISVMGHGMGIPSCSIYAKELITEFGVKKIIRVGSCGAVRSDVKLRDVVIGMGACTDSKVNRMRFKDHDFAAIADFDMVRNAVDAAQALGVKARVGNIFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALAICTVSDHIRTHEQTTAAERQTTFSEMIEIALESVLLGDKA
>NC_012214.1|WP_012667021.1|769525_770749_+|phosphopentomutase
MKRAFIMVLDSFGIGASKDADKFGDKGADTLGHIAGACFRGEADKGRQGPLHLPNLTALGLGKAAEASSGKFPPGLDGNAEIIGAYAYASELSSGKDTPSGHWEIAGVPVLFDWGYFSDTQNSFPQELLDLLVEKAELPGYLGNCHSSGTVILDQLGEEHMKSGKPIFYTSADSVFQIACHEETFGLERLYALCEIAREALTEGGYNIGRVIARPFVGDKPGHFERTGNRHDLAVEPPAPTVLKKLVDEQGGEVISVGKIADIYAHVGITKKVKATGLDALFDATVGEMRTAPDNSIVFTNFVDFDSTWGHRRDVPGYAAGLELFDRRLPELMAQVKEGDILILTADHGCDPSWHGTEHTREHIPVLIFGPGVKPGDYGYRETFADIGQTVAHYFGLSPMAYGKPLF
>NC_012214.1|WP_012667020.1|768139_769462_+|thymidine-phosphorylase
MFLPQEIIRKKRDGHALSEEEIRLFINGVCDNSVSEGQIAALAMAIWFRDMTLPERVALTMAMRDSGSVLSWKALDLNGPVVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPQDDRFRQIIKQVGVAIVGQTRSLAPADKRFYATRDITATVDSIPLIAASILAKKLAEGLDALVMDVKVGSGALMPALEQSEALAQAIFGVANGAGCHTTVLLTDMNQALASRAGNALEVREAVQFLTGEYRNPRLLEVTMALCSEMLLSGGLAQSGDEAQIKLQAVLDNGAAAEVFARMVAAQKGPTDFIERIDSYLPVPMLSKAVYANTSGIVSAMDTRALGMAVVALGGGRRRASDSIDYSVGFSDLVQLGDKVGSQRPLAVIHAASEAGWQQAARALQHAVVVGQVAPASTPVIYRRISQ
>NC_012214.1|WP_012667019.1|767226_768006_+|deoxyribose-phosphate-aldolase
MSDAKAQALRALQLMDLTTLNDDDTDANVIGLCRQAKSPAGNTAAICIYPRFIPLARKTLREQGTPEIRIATVTNFPHGNDDIDIALAETRAAIAYGADEVDVVFPYRALIAGNETVGFELVKACKQACSAANVLLKVIIESGELKEEALIRQASEIAIDAGADFIKTSTGKVSVNATPAVAEIMMRTIAAKGVHQQVGFKPAGGVRTADDAALYLQLADDILGPDWADARHFRFGASSLLASLLNAAGFSAATSDSDY
>NC_012214.1|WP_012667018.1|766182_766959_+|metal-dependent-hydrolase
MTPCFVDTHCHFDFPPFVGDEEASLQRAAQAGVEKMIAVSVSATRFDRVMALAERHYAVYAALGLHPMAVAEHNEQSLVALEQHLQRRHHKVVAIGEIGLDLFIDNPQFERQQALLDAQLRLARDYSLPVILHSRRTHDKLAQQLRRFDLARRGVVHGFAGSEQQALAFIRAGYAIGVGGTITYERASKTRQTIARLPLTSLVLETDSPDMPLQGFQGQPNRPERVRDIWHALCALRDESPQQITETLRENTRTLFGV
>NC_012214.1|WP_012667029.1|779199_780939_+|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein
METIILKIKPSVVVFITIVSGQSSGEMLPTLIDPNNPTRQSRDVPGPEPARSPAPTGSLPELAAPPPAMTLQTLVTFDRIHFIGGTRYPLATLTEPFSALVGKKVPLQTLLAATDSITQRYHRDGYPLSYAYIPADNFHQGVLNIGLVEGYVANSQIRSDNQQIGRWLGALSQRIMAEKPLTQDTFDRYSMLMARTPDTKVKATAKNPENIYGATVLDVDAQRTHNWNVINTLDMRKKQSLDLVSATLSGLTPYGEQLGVATIIPLNNQTRESYLGLNYQQFLGDDGLQLQVKGSYLNQNPRDFTTLLTQANGVNINAREKEVLYNAGVGLNYPLLLTAKQQWSLGGELDYVHKRYDYTLQAEQGGQTVSLPAINQHLRYPAAELNLSGSRQYQQASWNTRFSVRQGIDGLGASNTTGPGDLSFTRWRFNGDAAWVFNQKWRLSSAVEGDWSDSSLPEPERLTFGAFHFGRGYPDSGATGDYGMGGQVEMRYLHDRSTGDWVKTIQPYVMIDAAHTAFHQSGLASQKLASYGAGVTFGDNRHYALSLEAARPIADVPIDSSKRDWRFSATFTYNFNSGT
>NC_012214.1|WP_012667030.1|781033_782035_-|zinc-binding-alcohol-dehydrogenase-family-protein
MTHKAIAISPENPQHFIEIRQPQLTPNEYDLLVEVKAASVNPVDTKVHKGAQKNGLQQPRVLGWDASGVVLATGSKVSGFNVGDEVFYAGDITRPGSNATHQLIDARITGHKPKTLDWAQAAAIPLTALTAWEGLFDRLHIDSEGEGKTLLIVGGAGGVGSLAIPFAKLHSKVKVIATASRPDSVQWCLDRGADLVINYHDMPGELEKHGLKQVDYIFCLNDTDGHWPAMSQLIAPQGQICTIVENAGPLDMEQLKLKSAALHFEFMYTRSMFTTPDIARQGDILNATAQLLDEGKITTSLSKTLNGLSVDTLSEAHRLVLEGHMRGKVVMVY
>NC_012214.1|WP_041473972.1|782132_783014_+|LysR-family-transcriptional-regulator
MVFKQLQDMALFALVAGCGSFTAAAVRAGLPKSSVSQRISQLEQALGIRLINRTTRQLNLTFAGERYLVHCQEMLQASERAGVVIERLRDNPSGRLRITSPAGIGATLLARVNTAFQHKYPDVTLEVSISDEMCNLVQSRFDVALRTGRPQDSSLIGRRIGYCQRLLVASPDYLADYPALAHPRQLSDHRCIAHRAWNEWLLKRNEEYYRWLLPPTHMTDNLVYARECALSSGGITLLPRFLSGEKLVQVLPEWEVEGNELWLVYPGRKLNSPALSRFVDFAMRSEILRDFYR
>NC_012214.1|WP_012667032.1|783078_784746_-|energy-dependent-translational-throttle-protein-EttA
MAQFVYSMHRVGKVVPPKRHILKNISLSFFPGAKIGVLGLNGAGKSTLLRIMAGIDKDIEGEARPQPGIKIGYLPQEPQLNLEHTVRESVEEAVAEVVGALKRLDEVYALYAAEDADFDKLAKEQGVLEEIIQAHDGHNLNTQLERAADALRLPDWDAKIANLSGGERRRVALCRLLLEKPDMLLLDEPTNHLDAESVAWLERFLHDFEGTVVAITHDRYFLDNVAGWILELDRGEGIPWEGNYSSWLEQKDARLAQEASSEAARRKSIEKELEWVRQGAKGRQSKGKARLARFEELNNTDYQKRNETNELFIPPGARLGDKVLEVSNLRKSYGDRLLIDDLTFSVPKGAIVGIIGPNGAGKSTLFRMMSGQEQPDSGSIVLGDTVKLASVDQFRDTMDNSKTVWEEVSGGQDIMRIGNTEMPSRAYVGRFNFKGVDQGKRVGELSGGERGRLHLAKLLQVGGNVLLLDEPTNDLDIETLRALENALLEFPGCAMVISHDRWFLDRIATHILDYQDEGKIAFFEGNFTEYEEYKKRTLGADALEPKRIKYKRMIK
>NC_012214.1|WP_012667034.1|785235_786321_-|ParA-family-protein
MDDMTSSDTIEQIQMAEINKKYLVWNNKGGVGKTFLTYNLAIEYAIIHPHEDVVVIDACPQSNVSEIILGGNGVGEENLNALRDRNTTIAGYIKERFSNSPLSRMGNESTYFVKADSVNAKMPDNLYLLPGDVDLDICSRLISHIGSSPVKEAWKKSRSLLIDLIASFEADKSIPDRPKTFFIDCNPSFASYTELGVVASNRIIIPCTADAASIRGIKNLVKLIFGVSIDNSEQDEMFLDFNKEAKQNKIELPKLHLFVQNRSRTNESDAAKAFKSHAEEIRRITDDLLKSHANLFTPDALAERVKNVKDGNTLAAIINHEGCPLSKLQHKSYTIYGMATQANKAQITSLESDVIQVVENL
>NC_012214.1|WP_012667035.1|786560_786926_-|hypothetical-protein
MNRLKLSEMPGGSQESRPGQEEGYGELAGYGIGGGRDDEIDIKVSQLATDVDYIRHDAAEIKSDVKAMDSRLIKIETGISAVKSALKSSAAVVSIGFALCACVFGSYVLKILDALNGLVLR
>NC_012214.1|WP_014538578.1|787863_789786_+|murein-transglycosylase
MADKWQWWIAAACLTVVAGSVRADSLDEQRSRYLQIKQAWDNKQMDTVNQLMPSLRDYPLYPYLEYRQLAQNLDQETGLAVNAFIKRYPTLPPVASLPARFVNQLAAREDWRGLLVFSPQPPKPVAARCNWYYAKWSTGQPQVAWGGAKDIWLTGSTLPAACDKLFSAWQQAGQQNPITTLERIRLAMKAGNTSLVNALAKQLPEDYQTIANAVLALQNNPQTVASFAATVGPTDFTRQASTIAFASLARSDAEQARQLIPRLVQLQKLDEQQTQALKEAVAWRLMSNDITSEQARWRDDVVMRSDSTTLVERRVRMALGNNDRHGMNTWIARLPVEAKEKDEWQYWQADLLLEQGRKEEADSILRKLMQQRGFYPMVAAQKLGVDYPLQVDKAPAPDGSLTQGTEIARVRELMYWGMDNLARSEWSYLISSRTTAQQQMLASYALSQNWWDLSVQATITGKLWNSLQERFPLAWQPQFTRYISGKATPVSYAMAIARQESAWNPKARSPVGASGLMQVMPATAQHTVSKFNMPGYSNSSQLLDAETNIQIGTQYLESVYQQFGENRIFASAAYNAGPSRVRTWQGNSAGKLDVVAFIETIPFSETRGYVKNVLAYDAYYRHFLNQSDKLFADNEWQQRY
>NC_012214.1|WP_014538579.1|789872_790205_+|trp-operon-repressor
MTDYSSVPVTADAPDKDWLRFVTLLQRACQSDLQLPLLQLMLTPDEREALGTRLRIVEELMCGEMSQRELKIELGAGIATITRGSNSLKSAPPALKAWLEAQLLTDSDKA
>NC_012214.1|WP_012667037.1|790190_790739_-|inosine/xanthosine-triphosphatase
MYHVVAATINPAKIKAISQAFSDIFGAGSCHIEGVEVDSGVAAQPISNTETRTGARQRVMNARQVRPEADFWVAIEAGIEDDTAFAWMVVENQKLRGESRSASFTLPAIVMKGIHQGRELGDEMARLTGIDNIKHKGGAIGAFTAGHLTRSSVYHQALILALCPFHNDIYQRKADDEDSGLI
>NC_012214.1|WP_012667038.1|790789_791437_+|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase-GpmB
MLQVYLVRHGETLWNAARRIQGQSDSALTEKGEQQAYQVGLRVKNLGITHVIASDLGRTRRTAEIIADACGCSVVVDPRLRELNMGVLEQRELDSLSAQEESWRKALVDGTENGRIPQGESMSEMAQRMRQALDACLSLPEGSLPLIVSHGMALGVLLSTILGLPANAERRLRLRNCSISRVDHQQSPWLASGWVVETAGDVAHLDDTALDELQR

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Crispr_ID: NC_012214_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012214_2

930383-931083

TypeI-E

I-E

Consensus_repeat	Method
GTGTTCCCCGCGTGAGCGGGGATAAACCG	PILER-CR
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CRISPRCasFinder
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CRT
GTGTTCCCCGCGTGAGCGGGGATAAACCG	PILER-CR

11 spacers

cas3,cas8e,cse2gr11,cas7,cas5,cas6e

The CRISPR arrays of NC_012214_2

>merge|NC_012214|2|930383-931083|PILER-CR,CRISPRCasFinder,CRT,PILER-CR
GTGTTCCCCGCGTGAGCGGGGATAAACCGCCTCGCGTCCGTGCGGGGCTTTGCTATCATTAGTGTTCCCCGCGTGAGCGGGGATAAACCGTTTATGACGCTGATTATTATCAGGCTAACCATGTGTTCCCCGCGTGAGCGGGGATAAACCGCCGGAAATTTATTTGTGAGTCGGGGAATTTGGGTGTTCCCCGCGTGAGCGGGGATAAACCGCGGGTTAAATGACGTCATGGCGACAGCATGAAGTGTTCCCCGCGTGAGCGGGGAATAAACCGAGTATCGAATAACGTTACCGTGGCCACCATCCGTGTTCCCCGCGTGAGCGGGGATAAACCGGGGAGAACTTGCTTATTATCTCAAACAAAGCGGTGTTCCCCGCGTAAGCGGGTATAAACCGCCGTGTTGAAGCCATTGGTGTTACCTCTATTTGTGTTCCCCGCGTAAGCGGGGATAAACCGGACGTAACAGTAAATGCGCCGGTTCGCGACAAGTGTTCCCCGCGTGAGCGGGGATAAACCGAGGTTAGAAACGAACAAGTCGGCATCAACGCCGTGTTCCCCGCGTGAGCGGGGATAAACCGCTTTGATGATAATTTTCTTGCTTCTATTACTAGTGTTCCCCGCGTGAGCGGGGATAAACCGTCCCGCTTTCACACAGGCCGGGATTAGCCGCTGTGTTCCCCGCGCCAGCGGGGATAAACCG

>NC_012214|2|1|930383-930594|PILER-CR
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CCTCGCGTCCGTGCGGGGCTTTGCTATCATTA
GTGTTCCCCGCGTGAGCGGGGATAAACCG	TTTATGACGCTGATTATTATCAGGCTAACCAT
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CCGGAAATTTATTTGTGAGTCGGGGAATTTGG
GTGTTCCCCGCGTGAGCGGGGATAAACCGCGGGTTAAATGACGTCATGGCGACAGCATGAAGTGTTCCCCGCGTGAGCGGGGAATAAACCGAGTATCGAATAACGTTACCGTGGCCACCATCCGTGTTCCCCGCGTGAGCGGGGATAAACCGGGGAGAACTTGCTTATTATCTCAAACAAAGCGGTGTTCCCCGCGTAAGCGGGTATAAACCGCCGTGTTGAAGCCATTGGTGTTACCTCTATTTGTGTTCCCCGCGTAAGCGGGGATAAACCG	GACGTAACAGTAAATGCGCCGGTTCGCGACAA
GTGTTCCCCGCGTGAGCGGGGATAAACCG	AGGTTAGAAACGAACAAGTCGGCATCAACGCC
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CTTTGATGATAATTTTCTTGCTTCTATTACTA


>NC_012214|2|2|930383-931083|CRISPRCasFinder
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CCTCGCGTCCGTGCGGGGCTTTGCTATCATTA
GTGTTCCCCGCGTGAGCGGGGATAAACCG	TTTATGACGCTGATTATTATCAGGCTAACCAT
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CCGGAAATTTATTTGTGAGTCGGGGAATTTGG
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CGGGTTAAATGACGTCATGGCGACAGCATGAA
GTGTTCCCCGCGTGAGCGGGGAATAAACC	GAGTATCGAATAACGTTACCGTGGCCACCATCC
GTGTTCCCCGCGTGAGCGGGGATAAACCG	GGGAGAACTTGCTTATTATCTCAAACAAAGCG
GTGTTCCCCGCGTAAGCGGGTATAAACCG	CCGTGTTGAAGCCATTGGTGTTACCTCTATTT
GTGTTCCCCGCGTAAGCGGGGATAAACCG	GACGTAACAGTAAATGCGCCGGTTCGCGACAA
GTGTTCCCCGCGTGAGCGGGGATAAACCG	AGGTTAGAAACGAACAAGTCGGCATCAACGCC
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CTTTGATGATAATTTTCTTGCTTCTATTACTA
GTGTTCCCCGCGTGAGCGGGGATAAACCG	TCCCGCTTTCACACAGGCCGGGATTAGCCGCT
GTGTTCCCCGCGCCAGCGGGGATAAACCG

>NC_012214|2|1|930383-931083|CRT
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CCTCGCGTCCGTGCGGGGCTTTGCTATCATTA
GTGTTCCCCGCGTGAGCGGGGATAAACCG	TTTATGACGCTGATTATTATCAGGCTAACCAT
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CCGGAAATTTATTTGTGAGTCGGGGAATTTGG
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CGGGTTAAATGACGTCATGGCGACAGCATGAA
GTGTTCCCCGCGTGAGCGGGGAATAAACC	GAGTATCGAATAACGTTACCGTGGCCACCATCC
GTGTTCCCCGCGTGAGCGGGGATAAACCG	GGGAGAACTTGCTTATTATCTCAAACAAAGCG
GTGTTCCCCGCGTAAGCGGGTATAAACCG	CCGTGTTGAAGCCATTGGTGTTACCTCTATTT
GTGTTCCCCGCGTAAGCGGGGATAAACCG	GACGTAACAGTAAATGCGCCGGTTCGCGACAA
GTGTTCCCCGCGTGAGCGGGGATAAACCG	AGGTTAGAAACGAACAAGTCGGCATCAACGCC
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CTTTGATGATAATTTTCTTGCTTCTATTACTA
GTGTTCCCCGCGTGAGCGGGGATAAACCG	TCCCGCTTTCACACAGGCCGGGATTAGCCGCT
GTGTTCCCCGCGCCAGCGGGGATAAACCG

>NC_012214|2|2|930811-931022|PILER-CR
	CCTCGCGTCCGTGCGGGGCTTTGCTATCATTA
GTGTTCCCCGCGTGAGCGGGGATAAACCG	TTTATGACGCTGATTATTATCAGGCTAACCAT
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CCGGAAATTTATTTGTGAGTCGGGGAATTTGG
GTGTTCCCCGCGTGAGCGGGGATAAACCGCGGGTTAAATGACGTCATGGCGACAGCATGAAGTGTTCCCCGCGTGAGCGGGGAATAAACCGAGTATCGAATAACGTTACCGTGGCCACCATCCGTGTTCCCCGCGTGAGCGGGGATAAACCGGGGAGAACTTGCTTATTATCTCAAACAAAGCGGTGTTCCCCGCGTAAGCGGGTATAAACCGCCGTGTTGAAGCCATTGGTGTTACCTCTATTTGTGTTCCCCGCGTAAGCGGGGATAAACCG	GACGTAACAGTAAATGCGCCGGTTCGCGACAA
GTGTTCCCCGCGTGAGCGGGGATAAACCG	AGGTTAGAAACGAACAAGTCGGCATCAACGCC
GTGTTCCCCGCGTGAGCGGGGATAAACCG	CTTTGATGATAATTTTCTTGCTTCTATTACTA
GTGTTCCCCGCGTGAGCGGGGATAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012214.1\|WP_012667166.1\|939244_939847_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	cd09664_cas6e_CAS-I-E	gnl\|CDD\|187858
NC_012214.1\|WP_012667151.1\|924310_924850_+\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|224187
NC_012214.1\|WP_014538612.1\|929020_929803_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NC_012214.1\|WP_012667153.1\|925923_926358_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NC_012214.1\|WP_012667161.1\|932890_935524_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031
NC_012214.1\|WP_012667150.1\|923682_924300_+\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NC_012214.1\|WP_012667158.1\|931416_931728_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|226194
NC_012214.1\|WP_012667165.1\|938591_939248_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09645_cas5_CAS-I-E	gnl\|CDD\|273842
NC_012214.1\|WP_012667148.1\|922293_922998_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NC_012214.1\|WP_012667157.1\|931162_931417_+\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|376852
NC_012214.1\|WP_012667164.1\|937494_938589_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	cd09646_cas7_CAS-I-E	gnl\|CDD\|378153
NC_012214.1\|WP_014538615.1\|931823_932162_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_012667147.1\|920759_922187_+\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|180579
NC_012214.1\|WP_012667152.1\|924890_925877_-\|zinc-dependent-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|176645
NC_012214.1\|WP_012667149.1\|923011_923686_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|275313
NC_012214.1\|WP_041474091.1\|932176_932446_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_012667154.1\|926357_927860_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236071
NC_012214.1\|WP_014538617.1\|937027_937498_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09670_cse2gr11_CAS-I-E	gnl\|CDD\|187801
NC_012214.1\|WP_014538611.1\|927822_929019_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NC_012214.1\|WP_012667162.1\|935520_937044_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09669_cas8e_CAS-I-E	gnl\|CDD\|236613

Protein	Function_ID	Function_description	E-value
NC_012214.1\|WP_012667166.1\|939244_939847_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|187858	cd09727, Cas6_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas6e. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6e is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-E subtype; Homologous to Cas6 (RAMP superfamily protein); Possesses double RRM/ferredoxin fold; also known as Cse3 family.	8.79116e-54
NC_012214.1\|WP_012667151.1\|924310_924850_+\|biotin-transporter-BioY	gnl\|CDD\|224187	COG1268, BioY, Uncharacterized conserved protein [General function prediction only].	4.10821e-38
NC_012214.1\|WP_014538612.1\|929020_929803_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	4.36361e-60
NC_012214.1\|WP_012667153.1\|925923_926358_+\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	7.38776e-30
NC_012214.1\|WP_012667161.1\|932890_935524_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	0
NC_012214.1\|WP_012667150.1\|923682_924300_+\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	1.72484e-24
NC_012214.1\|WP_012667158.1\|931416_931728_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|226194	COG3668, ParE, Plasmid stabilization system protein [General function prediction only].	2.863e-09
NC_012214.1\|WP_012667165.1\|938591_939248_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|273842	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.	6.20038e-64
NC_012214.1\|WP_012667148.1\|922293_922998_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.59903e-51
NC_012214.1\|WP_012667157.1\|931162_931417_+\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	6.51705e-10
NC_012214.1\|WP_012667164.1\|937494_938589_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	3.9095e-121
NC_012214.1\|WP_012667147.1\|920759_922187_+\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|180579	PRK06467, PRK06467, dihydrolipoamide dehydrogenase; Reviewed.	0
NC_012214.1\|WP_012667152.1\|924890_925877_-\|zinc-dependent-alcohol-dehydrogenase-family-protein	gnl\|CDD\|176645	cd05282, ETR_like, 2-enoyl thioester reductase-like. 2-enoyl thioester reductase (ETR) catalyzes the NADPH-dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the alcohol dehydrogenases in this family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. Candida tropicalis enoyl thioester reductase (Etr1p) catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis. Etr1p forms homodimers with each subunit containing a nucleotide-binding Rossmann fold domain and a catalytic domain.	1.27813e-127
NC_012214.1\|WP_012667149.1\|923011_923686_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|275313	TIGR04520, ECF_ATPase_1, energy-coupling factor transporter ATPase. Members of this family are ATP-binding cassette (ABC) proteins by homology, but belong to energy coupling factor (ECF) transport systems. The architecture in general is two ATPase subunits (or a double-length fusion protein), a T component, and a substrate capture (S) component that is highly variable, and may be interchangeable in genomes with only one T component. This model identifies many but not examples of the upstream member of the pair of ECF ATPases in Firmicutes and Mollicutes. [Transport and binding proteins, Unknown substrate].	1.80801e-85
NC_012214.1\|WP_012667154.1\|926357_927860_+\|AMP-binding-protein	gnl\|CDD\|236071	PRK07638, PRK07638, acyl-CoA synthetase; Validated.	4.27901e-83
NC_012214.1\|WP_014538617.1\|937027_937498_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|187801	cd09670, Cse2_I-E, CRISPR/Cas system-associated protein Cse2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; also known as Cse2/CasB/YgcK family; specific gene for I-E subtype;.	1.80409e-22
NC_012214.1\|WP_014538611.1\|927822_929019_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.01295e-151
NC_012214.1\|WP_012667162.1\|935520_937044_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|236613	PRK09693, PRK09693, Cascade antiviral complex protein; Validated.	0

>NC_012214.1|WP_014538612.1|929020_929803_-|enoyl-CoA-hydratase/isomerase-family-protein
MNADKPITRLVLCDRPAEHVVRLTLNRPARRNAYNAQMVGELEQWLNWCERQSAVRTVILTAGGEAFCSGADLHVAFSHGGEGLRNSSGGYHPLQHLPRRKIWIAALNGHAMGGGLEMALACDFIVASEQVHIALPEVRHGLLPLGGAISQLAALLPPNIARELLLTGEAMDARRALALGLFNQVVNAERLADAALALAERLNQAAPLAVQACNALLNQALAADISQQSDRELQQLQRSEDYQESLRAFAERRAAQWQGR
>NC_012214.1|WP_014538611.1|927822_929019_+|thiolase-family-protein
MAAIQSLLNYQPEDDRQPVIVAARRTPVGRAYGSLASVPPEALLAPLFNKLLPAGMTAIDEVIIGNATGGGGNIARLAALAAGVPMTVPAVTVDRQCGSGLEAVINACRLVQARAGECYLAGGVESVSNAPWRVEKPATLKQMPRFYPRARFSPDEIGDPDMGIAAENVARQCAISRERQDRFALRSHQRALAAAQQGAFREEIVPLNLGHCLVENDECPRPGTSLAQLAALPPVFAADGSVTAGNCCPLNDGAALLLVMSRRRARECGFTQGLLFADACSAGVDPNLLGLGPVPATEKLLRRQPGLTLDGVEVIEFNEAFAAQVLASVDALGIDEHRINQQGGAIALGHPYGASGAIMVTRLFSQLVSQRQSEGYGLAMLGIAGGLGLSALFKGVQL
>NC_012214.1|WP_012667154.1|926357_927860_+|AMP-binding-protein
MPVQDRVQRHAAKKPHDDALNIDGETLSWLQLWQSSNALYQHLCRLSLATGVVAIASANDITFPVAWLAATARPFTAVVIDPLTPEDNLRDILNRLKPDLLLLQRQNHRLIALAQRLEIRWLALDGWQHAQPVADDDAFCADMQAATPFLIGFTSGTTRLPKAFIRSRRSWRCSFENGVEIFRLAHAPSTLFPGPLSHGIGLYCLNETLYAGGCFYSTARWQPQAVLMLLAQQQIERLVVVPTMIAGLAAAAAQSDYPGLRSLLSAGAKLELNHWRLARALFPQAVMQEYYGASELGFVAVSTLDDDNISTSLASVGQAFPATEITIRNDEGELLPAGQPGTIWLASEQIIDGYLWGDDDSAFKKRPWGATVADIGYLDAQQRLHIIGRRGNMILSGGNNIYLSEVESVIKSLPGVTEAVVIAVDDAYLGKKMVAVIEAADDVIHQLPQQSCPLLAKYKLPRHYYQIKRWPLTSGGKIKRAELEQRIKDGSYTELTELSA
>NC_012214.1|WP_012667153.1|925923_926358_+|acyl-CoA-thioesterase
MQQRNSETFRISMRDIDLNGHVHNSVYLDYFEDAVVNAFRRYHLLPLFRPQSAGVAYHVKKCEATFHHPLTVDDEVMPQVAVAKLGNSSLIFSIQLLLADKSTLCAEGKLIWVCVNPLDNKPCPIPDETRAALRQHLPFIEASA
>NC_012214.1|WP_012667152.1|924890_925877_-|zinc-dependent-alcohol-dehydrogenase-family-protein
MKASLFTRAMVREFGNIEDILRLEQAELPELADGQVRVKMSFATINPSDVITLSGAYRSRIALPFVPGFEGVGSICQSNDPALAVGQRVLPVGSMGAWQNYKDSAARWCFTLPDFVSDRQAATGYVNPMTALLMLSEALEFTPGMRIMINAANSAIGKMLIRIANHMGLEPVAIVRKAENLRLFTGYATQSLLNSSAPDYPQALAALQRSGGVAAIFDCIGGDESLTLARALAPGGQFIHYGLLSGQPIPPAFWRSRPDIRFSHFHLRMWVHGHDKAVVQSKIDEVMALIRDGVIATEIVAEYALAGIDKAVAAVRSGELKGKILLRL
>NC_012214.1|WP_012667151.1|924310_924850_+|biotin-transporter-BioY
MSTKDIVYIALFAAMTAALGLFPAFNLPVIAVPITAQSMGCMFAGAIAGAKRGALAMVLFDLLVAIGLPLLAGGRGGFGIFIGPGAGFILAWPLAALLIGWLYRRSLHSLTWVKELLIVALGGLVLVYSMGIPWIAAVAGISLKQAAVASLGFLPGDLLKVVLVVAIVRTVRRAWPTLE
>NC_012214.1|WP_012667150.1|923682_924300_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MTVSDYQPGDSAIHRLPPGIKILALAVTGTLLFVFPRLAFAVAVLFVIALCYPLARIPGRTLLLQLKPLLWLLLLLFAVQWWMVSWQSGLLVIVRLAALMLMAALVTLTTRTSAMIEALEKGLFWLRFMRINPAKISLALALALRFIPVLAAITLEVREAQRARGLDHSILAVAVPVMVRTLKMADDIAAALEARAYDPQPQRKT
>NC_012214.1|WP_012667149.1|923011_923686_+|ATP-binding-cassette-domain-containing-protein
MLELQGVSHAFAERQVLNNINLQLTEKRIGIVGSNGCGKSTFARLLNGLLLPKQGEVRVDGLNTRQHGKAVRRKVGFVFQNPDNQIVFPLVEEDLAFGMKNLGLSKATIRERTDAALARYDMQDLRQHPAHLLSGGQKQLLAISGVLVMEPQYIVFDEPTTLLDLRNKRRIAEAIAGLDQTAIVVSHDLDFLQDFDRVLVFEGGQVVADDIPAVALNAYIRMMS
>NC_012214.1|WP_012667148.1|922293_922998_+|SDR-family-oxidoreductase
MSEKVALITGASRGIGHHLARHFYAQGYQLILVARDAQRLASFAATLDAARVQTLALDLCDHPAVAQRLQLALATHQQLDVLVNAAGIFRPGSTQTPLSDFSALLATNVTAIHHLCQLCTPWLLKSAAGRIFNLASIGGVQPYGSVASYAASKHALVGYSRSIARELGMQGIKVTTLCPDVVDTDMAQGSGFEADEMLSTADICRAVDFVMSLSPAAVVDLLTIGRQPRPRQPA
>NC_012214.1|WP_012667147.1|920759_922187_+|dihydrolipoyl-dehydrogenase
MSTEIKTQVVVLGAGPAGYSAAFRAADLGLETVIVERYSTLGGVCLNVGCIPSKALLHVAKVIEEAKSLEAHGIVFGKPQTDIDKVRGWKEKVISQLTGGLAGMAKGRKVNVVNGLGKFTGANTLEVTAEEGSKTTITFDNAIIAAGSRPIELPFIPHEDPRVWDSTDALELKEVPERLLVMGGGIIGLEMATVYHALGSQIDVVEMFDQVIPAADKDVVKVFTKRISKQFNLMLETKVTAVEAKEDGIYVTMEGKKAPSEPQRYDAVLVAIGRVPNGKGLDAGKAGVEVDDRGFIRVDKQMRTNVPHIFAIGDIVGQPMLAHKGVHEGHVAAEVISGKKHYFDPKVIPSIAYTEPEVAWVGLTEKEAKEQGISYETSTFPWAASGRAIASDCADGMTKLIFDKNTHRVIGGAIVGTNGGELLGEIGLAIEMGCDAEDIALTIHAHPTLHESVGLAAEIFEGSITDLPNPKAKKK
>NC_012214.1|WP_012667157.1|931162_931417_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MLSFTANQAKTQFGDLMTKAQREPVSITCNGRPAVVVVPAEDYAVLEQLKLEALRTRLTRSIAQMEAGQVHDGDAVFDELMKDL
>NC_012214.1|WP_012667158.1|931416_931728_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MGKFTLTDDAKEDMKEIRAYSVQQWNKEVAKVYLEGMRLTMQMLANHPDIGDDVSDRLGAGVRSWLYQSHHLYIVSASAGVTAIGILHQTRLPSTLKKREISD
>NC_012214.1|WP_014538615.1|931823_932162_-|hypothetical-protein
MSKQYSIAVAPMAYQCLQDIESFKSGSIGAQQAASLVERLLMDSIKNIKEDPERYRFNAHLSDRGLMLRERLDVESEYRLLYDFDGEHIEILLFISMKQDFDKQLYRYNILK
>NC_012214.1|WP_041474091.1|932176_932446_-|hypothetical-protein
MNQTMSQKLARDSLGNAQSFEGGMYITKNGVAELFIQTAAERQAELREIEQERNINALFKLAMMAKKEIADGKGMSPEDVVERLRAARK
>NC_012214.1|WP_012667161.1|932890_935524_+|CRISPR-associated-helicase/endonuclease-Cas3
MNSPPGYYRYWGKAIAVTPEGETACHLLPWHCLDVAAVAARWWDNSPSLRSQFSAESSPAPQVRAWVLFFVALHDFGKFDIRFQAKAPAALRILNPDGLNISGRLPPWDHGKGGVLCLRNDFRENPASDDSLLSFLDEAPHSKQAWFPWMEAVAGHHGYVVREYDLSDEVMNYPPGLQGRADADRQARMAWLQALERLFLQPVGLCLQDNPPPVFPLLAGFCSVSDWLGSWSSEETFRYQSSVESLDNYFAQRYACDAAIVLERSGLVAQVKPWSGVAALLEKGHAPRQLQTLVDRLPEQPGLTLIEAPTGSGKTEAALAYAWRLLAGGQADSIIFALPTQATANAMYSRLERLATQLFERPNFILAHGYARFNPVFGAVKQRAANVQQAEEGWAQCCEWLSRGSKRAFLGQIGVCTVDQVLISVLPVKHRFIRGFGLGRSVLLVDEVHAYDSYMYGLLEAVLRAQSAAGQSALLLSATLPGHLKQRLLATYPVDNAAQLSSEYPLVTWRGQTQQRHFDLSATPEHLPAETTLLLEHRYLAESEPDELLLQEMVDAAAAGAQVCLICNLVDVAQKTWQRLMAYGQAEVLLFHARFTLTDRIAKEQQVLEYFGPHGNRRQGRILVATQVVEQSLDVDFDWLITQLCPVDLLFQRGGRLHRHQRNRRPAGFSQPLLTVLLPDAEGYGRSGYIYGNTRVMWRTQQLIEAQGATPLPFPAAWRQWIEPVYRPETDDAEPVWVQEGYRAWEQKEFEKRASARLMLKQAEHATPFSDNDQPVRALTRDGEMSVAVIPYYHSEHGKVLLDGQVLDRLSELARPEALVLNLVNVPHSWQSAFLQPMDEQGIIWLPGHLVDEKTEFTGKGQYHFTYSHHEGMEKTG
>NC_012214.1|WP_012667162.1|935520_937044_+|type-I-E-CRISPR-associated-protein-Cse1/CasA
MNLLTDDWIPVRPLSGGEGQQITLQTLLCDDRRWLVALPRDDMEMATFQLLVCLLQTLWMPSDAQQLVQRIRQPLSAREFADGVAGWQQAFDLNHPQQPFMQVRGVAAKEVTGMDKLLVGLTGSTSGAFVNQSGQGKALCSGCTAIALFNQACNAPGFGGGFKSGLRGGSPVTTLVQGDCLRTTLWFNVLSETTLDEFCPDWREQRAQPFTWQQPIKKDQAIAGSSIGLARGLFWQPAHIELSPPDGAGQCSACGRMASQRYRSFLKEKFNFTVNGLWLHPHSPLIQQIKKGQVEWRYMAFSTPAPSWTQIGRLLIEQQVNKQQEGRRVATTVEQARMLSRGRALRLMIGGYRNNQASIIERRHEVLQFNQGWQHAMPVINEIVNLGLEYRKALRTALWIFAEGAKESDIKGAGVALHEKVDPQYYRQSHARVLNLLAQIDYQSPLPQLEQFQTQQQQLCQQLFNDLTAPYAHHPKLICSLAKARRYLMSSLAKLKPQGEHLHGAAV
>NC_012214.1|WP_014538617.1|937027_937498_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MEQPFNAETLYQNWSELDPGSKAKIRRATRPDDLMDIPAFYLLVAPSGWPQHRYALLRMAFCLSAGKIRLSEDKQQSIGRAFAEKGISQPRIFQVIRADYPNDMVQLRRLIIHAEPEVYWPAFARQLYGWYQSDRRKLLEDFVLTTANKPSRKDAK
>NC_012214.1|WP_012667164.1|937494_938589_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MNNFINCHVLISHSPSCLNRDDMNMQKDAVFGGKRRVRISSQSLKRAMRKSAYYQQHLGDSSMRTIHLADLRHVVHARLADKHTADIIDKALSLLSGKTIDGAEKIDGGAVSPWVMDEIDWFCQQLTLPEYADFDEKKWTKLLKEQINALRATLNNAVDVALSGRMATSGLMSEVGNVDGAMSVAHAITTHAVEADIDWFTAVDDLKETTGAAHLGTQEFSSGVFYRYASLNLSQLQQNLGGATREQALTIAAHLVHMLATEIPGAKQHSFAAFNPADLVMVNFSDFPLSLANAFEQPVVAKKDGFLQPSVAALNDYWARVAAGYGIDGPTAQFSLAESAMPVGVQRMAGLAALKTWVSSHGEG
>NC_012214.1|WP_012667165.1|938591_939248_+|type-I-E-CRISPR-associated-protein-Cas5/CasD
MTDYLIMRLCGPMQAWGLPGFEATRPSAPFPTRSGLLGLLGACLGIPRSDRTALQQLADSVRFAVRCDDDRPYQTVSRVDFHTVQDARKEHGSLKSNDTILTWREYLYDAAFTVALWTPAADKPGYTLEQLKIALQKPVFTPYLGRRSCPLSQPLFYAQQQAQHPGQALSEASPGKGVIYSEMAISGNERRLTMRDEPLIHLPRQFASRTWYAIAGEQ
>NC_012214.1|WP_012667166.1|939244_939847_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MIYLSQIDVPWSWAKDPYQMHRALWQLFPDRPSDRRDFLFRVETRHAGSGQRVLLQSPQLPQNCAAAKVLASKVMHLNLSPGQRLHFRLRANPVKTIKDKRGRLNSRGEVKSCRVPLIDDNQLMQWLVRKLEGAAVLNSASVSKEPALCFNKQAVAGKIQPVCFEGILQVTSETHFYQCMADGIGPAKSMGCGMLSIARA

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Crispr_ID: NC_012214_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012214_3

941216-942161

TypeI-E,TypeI-F

I-E

Consensus_repeat	Method
GTGTTCCCCGCGTATGCGGGGATAAACCG	PILER-CR
GTGTTCCCCGCGTATGCGGGGATAAACCG	CRISPRCasFinder
GTGTTCCCCGCGTATGCGGGGATAAACCG	CRT

15 spacers

cas2,cas1,cas6e,cas5,cas7,cse2gr11,cas8e,cas3,cas3f

The CRISPR arrays of NC_012214_3

>merge|NC_012214|3|941216-942161|PILER-CR,CRISPRCasFinder,CRT
GTGTTCCCCGCGTATGCGGGGATAAACCGCCTTCCAGCCCTCTGAGTGAGGGCTTTCCGTAGTGTTCCCCGCGTATGCGGGGATAAACCGGCTTAATGCCTTTGCCGATGCATTTTCCTTTTGTGTTCCCCGCGTATGCGGGGATAAACCGACAGTCAACCAGTACCACTCCATTTTTTTCGTGTGTTCCCCGCGTATGCGGGGATAAACCGAAAGTTTGGCAGATGCGCTACAAGATTGAAGGGTGTTCCCCGCGTATGCGGGGATAAACCGGAAAAAATATCCGACCTCCGCGAAAAGCAGGAGTGTTCCCCGCGTATGCGGGGATAAACCGCCTGGTTGTAGGAGTGGGGCCGACCCGTACCGGGTGTTCCCCGCGTATGCGGGGATAAACCGGCCACTAGAATCAGCAGCCCGCATCAATTGCCGTGTTCCCCGCGTATGCGGGGATAAACCGACGGATGTTGATATTGGGGACGTAATAGGTTGGTGTTCCCCGCGTATGCGGGGATAAACCGGTCAGGTAAAAGGACACTCGGTGGAAATAATTGTGTTCCCCGCGTATGCGGGGATAAACCGCATGGCCACCCGGCCAACCACGATCCAGTTATGTGTTCCCCGCGTATGCGGGGATAAACCGCTGCAATAGCAGTACTCGTGCCTTTTTCTTATGTGTTCCCCGCGTATGCGGGGATAAACCATATGAATGAATATCTACGCAGTAAATGGGAATGTGTTCCCCGCGTATGCGGGGATAAACCGGTGATCTGCGCTGCTTCTGCCACTGTGCATTCGTGTTCCCCGCGTATGCGGGGATAAACCGTTGTCGCAATCGCTGCTGGTGAGTGGTTCGTGGTGTTCCCCGCGTATGCGGGGATAAACCGTGCGGGTTGGCCAGATTGGGCGCACGGCTCATGTGTTCCCCCGCATATGCGGGGATAAACCG

>NC_012214|3|3|941216-942099|PILER-CR
GTGTTCCCCGCGTATGCGGGGATAAACCG	CCTTCCAGCCCTCTGAGTGAGGGCTTTCCGTA
GTGTTCCCCGCGTATGCGGGGATAAACCG	GCTTAATGCCTTTGCCGATGCATTTTCCTTTT
GTGTTCCCCGCGTATGCGGGGATAAACCG	ACAGTCAACCAGTACCACTCCATTTTTTTCGT
GTGTTCCCCGCGTATGCGGGGATAAACCG	AAAGTTTGGCAGATGCGCTACAAGATTGAAGG
GTGTTCCCCGCGTATGCGGGGATAAACCG	GAAAAAATATCCGACCTCCGCGAAAAGCAGGA
GTGTTCCCCGCGTATGCGGGGATAAACCG	CCTGGTTGTAGGAGTGGGGCCGACCCGTACCGG
GTGTTCCCCGCGTATGCGGGGATAAACCG	GCCACTAGAATCAGCAGCCCGCATCAATTGCC
GTGTTCCCCGCGTATGCGGGGATAAACCG	ACGGATGTTGATATTGGGGACGTAATAGGTTG
GTGTTCCCCGCGTATGCGGGGATAAACCG	GTCAGGTAAAAGGACACTCGGTGGAAATAATT
GTGTTCCCCGCGTATGCGGGGATAAACCG	CATGGCCACCCGGCCAACCACGATCCAGTTAT
GTGTTCCCCGCGTATGCGGGGATAAACCG	CTGCAATAGCAGTACTCGTGCCTTTTTCTTAT
GTGTTCCCCGCGTATGCGGGGATAAACCA	TATGAATGAATATCTACGCAGTAAATGGGAAT
GTGTTCCCCGCGTATGCGGGGATAAACCG	GTGATCTGCGCTGCTTCTGCCACTGTGCATTC
GTGTTCCCCGCGTATGCGGGGATAAACCG	TTGTCGCAATCGCTGCTGGTGAGTGGTTCGTG
GTGTTCCCCGCGTATGCGGGGATAAACCG

>NC_012214|3|3|941216-942161|CRISPRCasFinder
GTGTTCCCCGCGTATGCGGGGATAAACCG	CCTTCCAGCCCTCTGAGTGAGGGCTTTCCGTA
GTGTTCCCCGCGTATGCGGGGATAAACCG	GCTTAATGCCTTTGCCGATGCATTTTCCTTTT
GTGTTCCCCGCGTATGCGGGGATAAACCG	ACAGTCAACCAGTACCACTCCATTTTTTTCGT
GTGTTCCCCGCGTATGCGGGGATAAACCG	AAAGTTTGGCAGATGCGCTACAAGATTGAAGG
GTGTTCCCCGCGTATGCGGGGATAAACCG	GAAAAAATATCCGACCTCCGCGAAAAGCAGGA
GTGTTCCCCGCGTATGCGGGGATAAACCG	CCTGGTTGTAGGAGTGGGGCCGACCCGTACCGG
GTGTTCCCCGCGTATGCGGGGATAAACCG	GCCACTAGAATCAGCAGCCCGCATCAATTGCC
GTGTTCCCCGCGTATGCGGGGATAAACCG	ACGGATGTTGATATTGGGGACGTAATAGGTTG
GTGTTCCCCGCGTATGCGGGGATAAACCG	GTCAGGTAAAAGGACACTCGGTGGAAATAATT
GTGTTCCCCGCGTATGCGGGGATAAACCG	CATGGCCACCCGGCCAACCACGATCCAGTTAT
GTGTTCCCCGCGTATGCGGGGATAAACCG	CTGCAATAGCAGTACTCGTGCCTTTTTCTTAT
GTGTTCCCCGCGTATGCGGGGATAAACCA	TATGAATGAATATCTACGCAGTAAATGGGAAT
GTGTTCCCCGCGTATGCGGGGATAAACCG	GTGATCTGCGCTGCTTCTGCCACTGTGCATTC
GTGTTCCCCGCGTATGCGGGGATAAACCG	TTGTCGCAATCGCTGCTGGTGAGTGGTTCGTG
GTGTTCCCCGCGTATGCGGGGATAAACCG	TGCGGGTTGGCCAGATTGGGCGCACGGCTCATG
TGTTCCCCCGCATATGCGGGGATAAACCG

>NC_012214|3|2|941216-942161|CRT
GTGTTCCCCGCGTATGCGGGGATAAACCG	CCTTCCAGCCCTCTGAGTGAGGGCTTTCCGTA
GTGTTCCCCGCGTATGCGGGGATAAACCG	GCTTAATGCCTTTGCCGATGCATTTTCCTTTT
GTGTTCCCCGCGTATGCGGGGATAAACCG	ACAGTCAACCAGTACCACTCCATTTTTTTCGT
GTGTTCCCCGCGTATGCGGGGATAAACCG	AAAGTTTGGCAGATGCGCTACAAGATTGAAGG
GTGTTCCCCGCGTATGCGGGGATAAACCG	GAAAAAATATCCGACCTCCGCGAAAAGCAGGA
GTGTTCCCCGCGTATGCGGGGATAAACCG	CCTGGTTGTAGGAGTGGGGCCGACCCGTACCGG
GTGTTCCCCGCGTATGCGGGGATAAACCG	GCCACTAGAATCAGCAGCCCGCATCAATTGCC
GTGTTCCCCGCGTATGCGGGGATAAACCG	ACGGATGTTGATATTGGGGACGTAATAGGTTG
GTGTTCCCCGCGTATGCGGGGATAAACCG	GTCAGGTAAAAGGACACTCGGTGGAAATAATT
GTGTTCCCCGCGTATGCGGGGATAAACCG	CATGGCCACCCGGCCAACCACGATCCAGTTAT
GTGTTCCCCGCGTATGCGGGGATAAACCG	CTGCAATAGCAGTACTCGTGCCTTTTTCTTAT
GTGTTCCCCGCGTATGCGGGGATAAACCA	TATGAATGAATATCTACGCAGTAAATGGGAAT
GTGTTCCCCGCGTATGCGGGGATAAACCG	GTGATCTGCGCTGCTTCTGCCACTGTGCATTC
GTGTTCCCCGCGTATGCGGGGATAAACCG	TTGTCGCAATCGCTGCTGGTGAGTGGTTCGTG
GTGTTCCCCGCGTATGCGGGGATAAACCG	TGCGGGTTGGCCAGATTGGGCGCACGGCTCATG
TGTTCCCCCGCATATGCGGGGATAAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_012214.1\|WP_012667177.1\|949707_951303_+\|multicopper-oxidase-CueO	unknown	unknown	gnl\|CDD\|236810
NC_012214.1\|WP_012667167.1\|939897_940839_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NC_012214.1\|WP_012667164.1\|937494_938589_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	cd09646_cas7_CAS-I-E	gnl\|CDD\|378153
NC_012214.1\|WP_012667175.1\|948223_949081_-\|polyamine-aminopropyltransferase	unknown	unknown	gnl\|CDD\|234843
NC_012214.1\|WP_012667161.1\|932890_935524_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031
NC_012214.1\|WP_012667166.1\|939244_939847_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	cd09664_cas6e_CAS-I-E	gnl\|CDD\|187858
NC_012214.1\|WP_012667179.1\|952540_953518_+\|type-I-F-CRISPR-associated-endonuclease-Cas1	cas1	cd09718_cas1_CAS-I-F	gnl\|CDD\|132676
NC_012214.1\|WP_012667170.1\|942655_943405_-\|toxin-transcriptional-activator-ToxR	unknown	unknown	gnl\|CDD\|226233
NC_012214.1\|WP_012667169.1\|942188_942659_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_012667165.1\|938591_939248_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09645_cas5_CAS-I-E	gnl\|CDD\|273842
NC_012214.1\|WP_012667173.1\|946948_947311_+\|YacL-family-protein	unknown	unknown	gnl\|CDD\|235372
NC_012214.1\|WP_014538615.1\|931823_932162_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_012667168.1\|940840_941125_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	cd09648_cas2_CAS-I-E	gnl\|CDD\|236930
NC_012214.1\|WP_041474091.1\|932176_932446_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_014538617.1\|937027_937498_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09670_cse2gr11_CAS-I-E	gnl\|CDD\|187801
NC_012214.1\|WP_012667180.1\|953514_956826_+\|type-I-F-CRISPR-associated-helicase-Cas3	cas3f	cd09673_cas3f_CAS-I-F	gnl\|CDD\|274201
NC_012214.1\|WP_012667162.1\|935520_937044_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09669_cas8e_CAS-I-E	gnl\|CDD\|236613
NC_012214.1\|WP_012667176.1\|949181_949529_-\|YacC-family-pilotin-like-protein	unknown	unknown	gnl\|CDD\|370620
NC_012214.1\|WP_012667172.1\|944177_946775_+\|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase	unknown	unknown	gnl\|CDD\|236424
NC_012214.1\|WP_012667174.1\|947398_948202_-\|adenosylmethionine-decarboxylase	unknown	unknown	gnl\|CDD\|235480

Protein	Function_ID	Function_description	E-value
NC_012214.1\|WP_012667177.1\|949707_951303_+\|multicopper-oxidase-CueO	gnl\|CDD\|236810	PRK10965, PRK10965, multicopper oxidase; Provisional.	0
NC_012214.1\|WP_012667167.1\|939897_940839_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	2.20885e-148
NC_012214.1\|WP_012667164.1\|937494_938589_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	3.9095e-121
NC_012214.1\|WP_012667175.1\|948223_949081_-\|polyamine-aminopropyltransferase	gnl\|CDD\|234843	PRK00811, PRK00811, polyamine aminopropyltransferase.	0
NC_012214.1\|WP_012667161.1\|932890_935524_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	0
NC_012214.1\|WP_012667166.1\|939244_939847_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|187858	cd09727, Cas6_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas6e. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6e is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-E subtype; Homologous to Cas6 (RAMP superfamily protein); Possesses double RRM/ferredoxin fold; also known as Cse3 family.	8.79116e-54
NC_012214.1\|WP_012667179.1\|952540_953518_+\|type-I-F-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|132676	TIGR03637, cas1_YPEST, CRISPR-associated endonuclease Cas1, subtype I-F/YPEST. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the YPEST subtype of CRISPR/Cas system.	0
NC_012214.1\|WP_012667170.1\|942655_943405_-\|toxin-transcriptional-activator-ToxR	gnl\|CDD\|226233	COG3710, CadC, DNA-binding winged-HTH domains [Transcription].	8.12936e-16
NC_012214.1\|WP_012667165.1\|938591_939248_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|273842	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.	6.20038e-64
NC_012214.1\|WP_012667173.1\|946948_947311_+\|YacL-family-protein	gnl\|CDD\|235372	PRK05248, PRK05248, hypothetical protein; Provisional.	3.79668e-65
NC_012214.1\|WP_012667168.1\|940840_941125_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|236930	PRK11558, PRK11558, putative ssRNA endonuclease; Provisional.	1.21933e-60
NC_012214.1\|WP_012667174.1\|947398_948202_-\|adenosylmethionine-decarboxylase	gnl\|CDD\|235480	PRK05462, PRK05462, adenosylmethionine decarboxylase.	0
NC_012214.1\|WP_014538617.1\|937027_937498_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|187801	cd09670, Cse2_I-E, CRISPR/Cas system-associated protein Cse2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; also known as Cse2/CasB/YgcK family; specific gene for I-E subtype;.	1.80409e-22
NC_012214.1\|WP_012667180.1\|953514_956826_+\|type-I-F-CRISPR-associated-helicase-Cas3	gnl\|CDD\|274201	TIGR02562, conserved_hypothetical_protein, CRISPR-associated helicase Cas3, subtype I-F/YPEST. The helicase in many CRISPR-associated (cas) gene clusters is designated Cas3, and most Cas3 proteins are described by model TIGR01587. Members of this family are considerably larger, show a number of motifs in common with TIGR01587 sequences, and replace Cas3 in some CRISPR/cas loci in a number of Proteobacteria, including Yersinia pestis, Chromobacterium violaceum, Erwinia carotovora subsp. atroseptica SCRI1043, Photorhabdus luminescens subsp. laumondii TTO1, Legionella pneumophila, etc.	0
NC_012214.1\|WP_012667162.1\|935520_937044_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|236613	PRK09693, PRK09693, Cascade antiviral complex protein; Validated.	0
NC_012214.1\|WP_012667176.1\|949181_949529_-\|YacC-family-pilotin-like-protein	gnl\|CDD\|370620	pfam09691, T2SS_PulS_OutS, Type II secretion system pilotin lipoprotein (PulS_OutS). This family comprises lipoproteins from four gamma proteobacterial species: PulS protein of Klebsiella pneumoniae (P20440), the OutS protein of Erwinia chrysanthemi (Q01567) and Pectobacterium chrysanthemi, and the functionally uncharacterized E. coli protein EtpO. PulS and OutS have been shown to interact with and facilitate insertion of secretins into the outer membrane, suggesting a chaperone-like, or piloting function for members of this family. In the pilotin from this four-helix protein from enterohemorrhagic Escherichia coli, the straight helix alpha2, the curved helix alpha3 and the bent helix alpha4 surround the central N-terminal helix alpha1. These helices create a prominent groove, mainly formed by side chains of helices 1,2 and 3 suggesting this groove is important as a binding site.	3.19667e-09
NC_012214.1\|WP_012667172.1\|944177_946775_+\|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase	gnl\|CDD\|236424	PRK09238, PRK09238, bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated.	0

>NC_012214.1|WP_012667168.1|940840_941125_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MSMLVVITENVPPRLRGRLAVWLLEVRAGVYVGDVSRRVREMIWQQLDQLYEEGNVAMVWATNSESGFEFQTLGENRRLPVDLDGLRLVSFYPV
>NC_012214.1|WP_012667167.1|939897_940839_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MSFVPLTPLPLKDRVSLVFLKYGQIDVLDGAFVLIDKTGVRTHIPVGSIACIMLEPGTRVSHAAVRLAATVGTLLVWVGEAGVRLYASGQPGGARSDKLLYQAKLALDSDLRLKVVRKMFALRFGEEAPARRSVEQLRGIEGGRVKATYALLAKQYGVEWHGRRYDIKDWDKGDMINQCISAATACLYGVTEAAMLAAGYAPAIGFVHSGKPLSFVYDIADIIKFDTVVPAAFAIAAARPPDAEKKVRLACRDAFRSGRILGKLIPLIETVLAAGEISPPPPPPPPPPPPPPDAQPVAIPEPQSLGDAGHRSS
>NC_012214.1|WP_012667166.1|939244_939847_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MIYLSQIDVPWSWAKDPYQMHRALWQLFPDRPSDRRDFLFRVETRHAGSGQRVLLQSPQLPQNCAAAKVLASKVMHLNLSPGQRLHFRLRANPVKTIKDKRGRLNSRGEVKSCRVPLIDDNQLMQWLVRKLEGAAVLNSASVSKEPALCFNKQAVAGKIQPVCFEGILQVTSETHFYQCMADGIGPAKSMGCGMLSIARA
>NC_012214.1|WP_012667165.1|938591_939248_+|type-I-E-CRISPR-associated-protein-Cas5/CasD
MTDYLIMRLCGPMQAWGLPGFEATRPSAPFPTRSGLLGLLGACLGIPRSDRTALQQLADSVRFAVRCDDDRPYQTVSRVDFHTVQDARKEHGSLKSNDTILTWREYLYDAAFTVALWTPAADKPGYTLEQLKIALQKPVFTPYLGRRSCPLSQPLFYAQQQAQHPGQALSEASPGKGVIYSEMAISGNERRLTMRDEPLIHLPRQFASRTWYAIAGEQ
>NC_012214.1|WP_012667164.1|937494_938589_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MNNFINCHVLISHSPSCLNRDDMNMQKDAVFGGKRRVRISSQSLKRAMRKSAYYQQHLGDSSMRTIHLADLRHVVHARLADKHTADIIDKALSLLSGKTIDGAEKIDGGAVSPWVMDEIDWFCQQLTLPEYADFDEKKWTKLLKEQINALRATLNNAVDVALSGRMATSGLMSEVGNVDGAMSVAHAITTHAVEADIDWFTAVDDLKETTGAAHLGTQEFSSGVFYRYASLNLSQLQQNLGGATREQALTIAAHLVHMLATEIPGAKQHSFAAFNPADLVMVNFSDFPLSLANAFEQPVVAKKDGFLQPSVAALNDYWARVAAGYGIDGPTAQFSLAESAMPVGVQRMAGLAALKTWVSSHGEG
>NC_012214.1|WP_014538617.1|937027_937498_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MEQPFNAETLYQNWSELDPGSKAKIRRATRPDDLMDIPAFYLLVAPSGWPQHRYALLRMAFCLSAGKIRLSEDKQQSIGRAFAEKGISQPRIFQVIRADYPNDMVQLRRLIIHAEPEVYWPAFARQLYGWYQSDRRKLLEDFVLTTANKPSRKDAK
>NC_012214.1|WP_012667162.1|935520_937044_+|type-I-E-CRISPR-associated-protein-Cse1/CasA
MNLLTDDWIPVRPLSGGEGQQITLQTLLCDDRRWLVALPRDDMEMATFQLLVCLLQTLWMPSDAQQLVQRIRQPLSAREFADGVAGWQQAFDLNHPQQPFMQVRGVAAKEVTGMDKLLVGLTGSTSGAFVNQSGQGKALCSGCTAIALFNQACNAPGFGGGFKSGLRGGSPVTTLVQGDCLRTTLWFNVLSETTLDEFCPDWREQRAQPFTWQQPIKKDQAIAGSSIGLARGLFWQPAHIELSPPDGAGQCSACGRMASQRYRSFLKEKFNFTVNGLWLHPHSPLIQQIKKGQVEWRYMAFSTPAPSWTQIGRLLIEQQVNKQQEGRRVATTVEQARMLSRGRALRLMIGGYRNNQASIIERRHEVLQFNQGWQHAMPVINEIVNLGLEYRKALRTALWIFAEGAKESDIKGAGVALHEKVDPQYYRQSHARVLNLLAQIDYQSPLPQLEQFQTQQQQLCQQLFNDLTAPYAHHPKLICSLAKARRYLMSSLAKLKPQGEHLHGAAV
>NC_012214.1|WP_012667161.1|932890_935524_+|CRISPR-associated-helicase/endonuclease-Cas3
MNSPPGYYRYWGKAIAVTPEGETACHLLPWHCLDVAAVAARWWDNSPSLRSQFSAESSPAPQVRAWVLFFVALHDFGKFDIRFQAKAPAALRILNPDGLNISGRLPPWDHGKGGVLCLRNDFRENPASDDSLLSFLDEAPHSKQAWFPWMEAVAGHHGYVVREYDLSDEVMNYPPGLQGRADADRQARMAWLQALERLFLQPVGLCLQDNPPPVFPLLAGFCSVSDWLGSWSSEETFRYQSSVESLDNYFAQRYACDAAIVLERSGLVAQVKPWSGVAALLEKGHAPRQLQTLVDRLPEQPGLTLIEAPTGSGKTEAALAYAWRLLAGGQADSIIFALPTQATANAMYSRLERLATQLFERPNFILAHGYARFNPVFGAVKQRAANVQQAEEGWAQCCEWLSRGSKRAFLGQIGVCTVDQVLISVLPVKHRFIRGFGLGRSVLLVDEVHAYDSYMYGLLEAVLRAQSAAGQSALLLSATLPGHLKQRLLATYPVDNAAQLSSEYPLVTWRGQTQQRHFDLSATPEHLPAETTLLLEHRYLAESEPDELLLQEMVDAAAAGAQVCLICNLVDVAQKTWQRLMAYGQAEVLLFHARFTLTDRIAKEQQVLEYFGPHGNRRQGRILVATQVVEQSLDVDFDWLITQLCPVDLLFQRGGRLHRHQRNRRPAGFSQPLLTVLLPDAEGYGRSGYIYGNTRVMWRTQQLIEAQGATPLPFPAAWRQWIEPVYRPETDDAEPVWVQEGYRAWEQKEFEKRASARLMLKQAEHATPFSDNDQPVRALTRDGEMSVAVIPYYHSEHGKVLLDGQVLDRLSELARPEALVLNLVNVPHSWQSAFLQPMDEQGIIWLPGHLVDEKTEFTGKGQYHFTYSHHEGMEKTG
>NC_012214.1|WP_041474091.1|932176_932446_-|hypothetical-protein
MNQTMSQKLARDSLGNAQSFEGGMYITKNGVAELFIQTAAERQAELREIEQERNINALFKLAMMAKKEIADGKGMSPEDVVERLRAARK
>NC_012214.1|WP_014538615.1|931823_932162_-|hypothetical-protein
MSKQYSIAVAPMAYQCLQDIESFKSGSIGAQQAASLVERLLMDSIKNIKEDPERYRFNAHLSDRGLMLRERLDVESEYRLLYDFDGEHIEILLFISMKQDFDKQLYRYNILK
>NC_012214.1|WP_012667169.1|942188_942659_-|hypothetical-protein
MRRCYFFIAAVILFSCGWFFAPWIILSNMEDCISKSIIIYDEPDRYIISRSTWFTYRGGQEHRYSAQVSIGGPQGKIDEFSSERTIETERRFNYDSINVNTVKSFRIAGILTSDPRMGKYIDPPAKEGFTGQIHLFRYRDSCILAGLKGGPLSICQ
>NC_012214.1|WP_012667170.1|942655_943405_-|toxin-transcriptional-activator-ToxR
MRVYFEPENCILSNDKMSIKITLQEGRCLDYLVKNEGKFIRREKLLEECWIKRGVTVSDSAVRQSLYRLRRAFEDAGLPPSTLTTQARKGHILQEGSIILLTAHASHNCVDIESSVPSMKKQGTYRHTHLYSTVTSLLPFAKFASLFVIFFLAGLYTRQQIMITEVNYHQAEEKEGRFYFYRKNQAPYESAASKINYWLDNKLVNASDMKYVYLNNSWAGNTSFYLCNEEIGSEGSHCTSVTVKGDYHS
>NC_012214.1|WP_012667172.1|944177_946775_+|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase
MLEEYRKHVAERAAQGIVPKPLDASQMAALVELLKAPPAGEEEFLSDLLTNRVPPGVDEAAYVKAGFLAAVAKGEATSPLVTPEQAVELLGTMQGGYNIHALIDALDDEKLAPLAAESLSHTLLMFDNFYDVEDKAKAGNPHAKKIIQSWADAEWFLKRPKLAEKITVTVFKVTGETNTDDLSPAPDAWSRPDIPLHALAMLKNAREGIEPDDAGNVGPIKQIEHLQEKGFPLAYVGDVVGTGSSRKSATNSVLWFMGDDIPNVPNKKGGGVCLGGKIAPIFFNTMEDAGALPIEVDVDRLNMGDVIDIYPYKGEVRNHETGEVLANFALKTEVLLDEVRAGGRIPLIIGRGLTTKARESLGLPHSDVFLQAKDVAASTRGFSLAQKMVGRACGVEGVRPGAYCEPKMTSVGSQDTTGPMTRDELKDLACLGFSADLVMQSFCHTAAYPKPVDVTTHHTLPDFIMNRGGVSLRPGDGIIHSWLNRMLLPDTVGTGGDSHTRFPIGISFPAGSGLVAFAAATGVMPLDMPESVLVRFKGKMQPGITLRDLVHAIPLYAIKAGLLTVEKKGKKNIFSGRILEIEGLPDLKVEQAFELSDASAERSAAGCTIKLGKDPIIEYLNSNIVLLKWMISEGYGDRRTIERRIQGMEKWLTDPQLLEGDADAEYAAVIDIDLAEIKEPILCAPNDPDDARLLSDVQGTKIDEVFIGSCMTNIGHFRAAGKLLDSHKGQLPTRLWVAPPTKMDAAQLTEEGYYSVFGKSGARIEIPGCSLCMGNQARVADGATVVSTSTRNFPNRLGTGANVYLASAELSAVASLLGKLPTPAEYQAFMDQVDKTAVDTYRYLNFDQLTQYTDKADAVIFQTAV
>NC_012214.1|WP_012667173.1|946948_947311_+|YacL-family-protein
MEYEFLSDITGAVKVRMSMGHEAVGHWFNDEVSGNPEILAEVEAAIAQVKGSERQWQRVGREYTLLLDEEEVMIRANQLGFEGDEMEEGMAYYDEESLSFCGVEDFLMVIAAYRAFLLGR
>NC_012214.1|WP_012667174.1|947398_948202_-|adenosylmethionine-decarboxylase
MKLQKLKLHGFNNLTKSLSFCIYDICYANTEAERDGYIAYIDEQYNANRLTEILSETCSIIGANVLNIARQDYEPQGASVTILVSEEPIDPRDIDTSEHPGPLPNSVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDVNGVKHFIDHEINSIQNFMSEDMKSMYDMMDVNVYQENMFHTKMMLKEFDLKHYLFNTKPEELSAQEHKRITGLLWKEMREIYYGRNIPAFG
>NC_012214.1|WP_012667175.1|948223_949081_-|polyamine-aminopropyltransferase
MAANEMWYETLHAGFGQYFSVDKVVYREQTDHQDLIIFENAALGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGNAKRVLIIGGGDGAMLREVCRHKNIEQITMVEIDAGVVTFCKQYLPNHNAGAYADARFELVIDDGVNFVNQTSDKFDVIISDCTDPIGPGESLFTSEFYQGCRRCLHQDGIFVAQNGVCFLQQDEAVNSHRKLSHYFGDVSFYQAAIPTYYGGIMTFAWASDNPALRQLDTATLTARFTEAGLKCRYYNPAIHTGSFALPQYLLNALAN
>NC_012214.1|WP_012667176.1|949181_949529_-|YacC-family-pilotin-like-protein
MKKSIKALLLSGLFGFTSTSFALSEPEAEDLADLTAVFVYLKNDCGYRDLPDAQIRRALVFFAQQNRWDLTNYSSFNMKALGEDSYRDLSGIAVPNDTKCKSLARDSLNLLAWVK
>NC_012214.1|WP_012667177.1|949707_951303_+|multicopper-oxidase-CueO
MQRRDFIKLSAALGAAGALPVWSRALMAAEQRPLLPIPTLLTPDARSEISLTAQASSSGWRGWGYNANLPGPALQLERGKEVNITVYNRLPEATTVHWHGLEVPGDIDGGPQARIEPNHSRRVTFTPDQPAATCWFHPHQHGRTGFQVAQGLAGLVLIADPESGKLLLPKQWGIDDIPVVLQDKRLSADGSRIDYQLDIISAAVGWFGDTMLTNGAIYPQHGVPRGWLRLRLLNGCNARSLNLTTSDKRPMYVIASDGGLLGEPVQVSELPMMPGERYEVLVNTTDGKAFDLQTLPVRQMGMTLEPFNQPLPVLSLVPLLVQASGTLPDKLASLPAMPSSQGLNTRWLQLMMDPELDRRGMQALMDKYGHAAMAGISMDAHGGGKKAGANNHDMSSMDHGKMATMNHGSSAQQQEYDFHNGNQINGMAFNRDKPSFEVKRGVYEKWTISGEGDEMLHPFHIHGTQFRILSENGKPPAAHRSGWKDTVRVEGWRSEVLVRFNHPADRAHAYMAHCHLLEHEDTGMMLGFTVA
>NC_012214.1|WP_012667179.1|952540_953518_+|type-I-F-CRISPR-associated-endonuclease-Cas1
MEMIKPSDLKTILHSKRSNIYYLQYCRVLVNGGRVEYVTDEGKQSLYWNIPIANTTVVMLGTGTSVTQAAMREFARAGVLVGFCGGGGTPLYAANEVEVDVSWLNSQSEYRPTEYLQHWVSFWFDEQKRLSAAIAFQHVRISQIRQAWLGSKMMREHKFAISEPQLTGILDRFEQGLARCNNNTDLLALEAVMTKALYKLAAQAVSYGDFIRAKRGGGIDAANRFLDHGNYLAYGLAAVACWVIGLPHGLAVLHGKTRRGGLVFDVADLIKDALILPQAFLAAMAGEEEQEFRQRCLTSLQNAEALDTMIAALEATARQYSQVGK
>NC_012214.1|WP_012667180.1|953514_956826_+|type-I-F-CRISPR-associated-helicase-Cas3
MNILLIAQCNKRALEDSRRILDQFAERKGDRSWQTAITQQGLLTLRKLLRKTARRNTAVACHWIKSNGQSELLWIVGNLRRFNAQGAVPTHTTSRDVLKSADENSWHSVEAVSLLAAIAGLFHDFGKANSLFQQMLVGKKGVKSFQPYRHEWVSLRLFCAWVAGRDDRAWIAALSDIGPQDEQAMLAGLQKDGLMPTKNPFDPLPPVARVVAWLILSHHRMPVYPKKDDLPPQMTWLPPELEHCDGWLTRELDALWNALNHHHDWKPAELQAQWQFPQGTPMQSGRWCGKARKMAQRLLAQPAWLAQIDINQRFSCHMARLALMLADHVYSRQAATPGWQDADCLPYANTDNGRPKQRLDEHNIGVAQNALLLARSLPHLRKTLPAIARHKGFKKRSENSTFRWQDNAWQATCNLRDRAFQQGFFGINMASTGCGKTFANARIMYALSDEQKGCRFAVALGLRTLTLQTGDALREKLKLEQDDLAVLVGSQAVTQLHQQAKDSPTPPVPGSESAAPLPEENQYVSYEGSLDDGRLSRWLKDSPRINKLLSAPVLVTTIDHLIGATEGLRGGKQIAPMLRLLTSDLVLDEPDDFDIEDQHALCRLVNWAGMLGSRVLLSSATLPPALVLALYNAYRSGREVFQHACGLPVDGNICCAWFDENAVLTEDLRLPQEFMQQHQEFVARRVSWLAKQPVLRRGWIAPVAPPARDDGTIYRHMAQVILQSMMTLHHAHHQRHPVSGKTISTGVIRLANINPLVAVAQQLLATGAAEDTHIHYCVYHSQHPLAMRSHFEQRLDATLTRHQPEAIWQVAEIAEALEQHPQQHHLFVVLATSVAEVGRDHDYDWAIAEPSSMRSLIQLAGRVQRHRQQEAQSENIHMLQQNIRSLKARDSQKPAYCQPGFEHKDYMLASHDLQQILDKEQYQTISAIPRIQQRREAKKRQPFTNLADLEHQRLMVELQGKQDKKDKQVKQDKPLPYCAALWWREQASWCGEMQRHKPFRQSQPEDMHFMLIAEEGDQPEIWQPDDGPSGRKQSMMTYPDLTFAAGISAWIAPDYQQVWQQLADSLTMELEEVSLRFGEIMLRSGRDDEIWHFHPLLGVFKAQ

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Crispr_ID: NC_012214_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012214_5

952312-952399

TypeI-E,TypeI-F

I-F

Consensus_repeat	Method
GTTCACTGCCGCACAGGCAGCTTAGAAA	CRISPRCasFinder

1 spacers

cas2,cas1,cas3f,cas8f,cas5f,cas7f,cas6f

The CRISPR arrays of NC_012214_5

>merge|NC_012214|5|952312-952399|CRISPRCasFinder
TTTTACTGCTGAACAAGCAGCTTAGAAAATAGCGATATATATTATTGATAGTTAATGATTTTTCACTGCCGTGCAGGCAGTTATAAAT

>NC_012214|5|5|952312-952399|CRISPRCasFinder
TTTTACTGCTGAACAAGCAGCTTAGAAA	ATAGCGATATATATTATTGATAGTTAATGATT
TTTCACTGCCGTGCAGGCAGTTATAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_012214.1\|WP_012667177.1\|949707_951303_+\|multicopper-oxidase-CueO	unknown	unknown	gnl\|CDD\|236810
NC_012214.1\|WP_012667167.1\|939897_940839_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NC_012214.1\|WP_012667181.1\|956899_957178_+\|BrnT-family-toxin	unknown	unknown	gnl\|CDD\|367913
NC_012214.1\|WP_012667175.1\|948223_949081_-\|polyamine-aminopropyltransferase	unknown	unknown	gnl\|CDD\|234843
NC_012214.1\|WP_012667183.1\|957919_959269_+\|type-I-F-CRISPR-associated-protein-Csy1	cas8f	cd09735_cas8f_CAS-I-F	gnl\|CDD\|187866
NC_012214.1\|WP_012667187.1\|962981_963659_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NC_012214.1\|WP_012667168.1\|940840_941125_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	cd09648_cas2_CAS-I-E	gnl\|CDD\|236930
NC_012214.1\|WP_012667179.1\|952540_953518_+\|type-I-F-CRISPR-associated-endonuclease-Cas1	cas1	cd09718_cas1_CAS-I-F	gnl\|CDD\|132676
NC_012214.1\|WP_012667170.1\|942655_943405_-\|toxin-transcriptional-activator-ToxR	unknown	unknown	gnl\|CDD\|226233
NC_012214.1\|WP_012667169.1\|942188_942659_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_012667186.1\|961246_961801_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	cas6f	cd09739_cas6f_CAS-I-F:CAS-IV	gnl\|CDD\|378224
NC_012214.1\|WP_012667173.1\|946948_947311_+\|YacL-family-protein	unknown	unknown	gnl\|CDD\|235372
NC_012214.1\|WP_012667182.1\|957164_957461_+\|BrnA-antitoxin-family-protein	unknown	unknown	gnl\|CDD\|373040
NC_012214.1\|WP_012667184.1\|959265_960210_+\|type-I-F-CRISPR-associated-protein-Csy2	cas5f	cd09676_cas5f_CAS-I-F	gnl\|CDD\|378221
NC_012214.1\|WP_012667188.1\|963973_965254_-\|cystathionine-gamma-synthase-family-protein	unknown	unknown	gnl\|CDD\|180809
NC_012214.1\|WP_012667174.1\|947398_948202_-\|adenosylmethionine-decarboxylase	unknown	unknown	gnl\|CDD\|235480
NC_012214.1\|WP_012667180.1\|953514_956826_+\|type-I-F-CRISPR-associated-helicase-Cas3	cas3f	cd09673_cas3f_CAS-I-F	gnl\|CDD\|274201
NC_012214.1\|WP_012667176.1\|949181_949529_-\|YacC-family-pilotin-like-protein	unknown	unknown	gnl\|CDD\|370620
NC_012214.1\|WP_012667185.1\|960233_961238_+\|type-I-F-CRISPR-associated-protein-Csy3	cas7f	pfam09615_cas7f_CAS-I-F	gnl\|CDD\|378222
NC_012214.1\|WP_012667172.1\|944177_946775_+\|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase	unknown	unknown	gnl\|CDD\|236424

Protein	Function_ID	Function_description	E-value
NC_012214.1\|WP_012667177.1\|949707_951303_+\|multicopper-oxidase-CueO	gnl\|CDD\|236810	PRK10965, PRK10965, multicopper oxidase; Provisional.	0
NC_012214.1\|WP_012667167.1\|939897_940839_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	2.20885e-148
NC_012214.1\|WP_012667181.1\|956899_957178_+\|BrnT-family-toxin	gnl\|CDD\|367913	pfam04365, BrnT_toxin, Ribonuclease toxin, BrnT, of type II toxin-antitoxin system. BrnT is a ribonuclease toxin of a type II toxin-antitoxin system that exhibits a RelE-like fold. The antitoxin that neutralizes this toxin is pfam14384. BrnT is found in bacteria, archaea, bacteriophage, and plasmids. BrnT-BrnA forms a 2:2 tetrameric complex and autoregulates its own expression, which is induced by a number of different environmental stresses. Expression of BrnT alone results in cessation of bacterial growth which can be rescued after subsequent expression of BrnA.	4.35797e-20
NC_012214.1\|WP_012667175.1\|948223_949081_-\|polyamine-aminopropyltransferase	gnl\|CDD\|234843	PRK00811, PRK00811, polyamine aminopropyltransferase.	0
NC_012214.1\|WP_012667183.1\|957919_959269_+\|type-I-F-CRISPR-associated-protein-Csy1	gnl\|CDD\|187866	cd09735, Csy1_I-F, CRISPR/Cas system-associated protein Csy1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins; Predicted subunit of the Cascade complex; signature gene for I-F subtype; also known as Csy1 family.	4.72601e-173
NC_012214.1\|WP_012667187.1\|962981_963659_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	4.5748e-10
NC_012214.1\|WP_012667168.1\|940840_941125_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|236930	PRK11558, PRK11558, putative ssRNA endonuclease; Provisional.	1.21933e-60
NC_012214.1\|WP_012667179.1\|952540_953518_+\|type-I-F-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|132676	TIGR03637, cas1_YPEST, CRISPR-associated endonuclease Cas1, subtype I-F/YPEST. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the YPEST subtype of CRISPR/Cas system.	0
NC_012214.1\|WP_012667170.1\|942655_943405_-\|toxin-transcriptional-activator-ToxR	gnl\|CDD\|226233	COG3710, CadC, DNA-binding winged-HTH domains [Transcription].	8.12936e-16
NC_012214.1\|WP_012667186.1\|961246_961801_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	gnl\|CDD\|378224	pfam09618, Cas_Csy4, CRISPR-associated protein (Cas_Csy4). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family, typified by YPO2462 of Yersinia pestis, is a CRISPR-associated (Cas) family strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy4, for CRISPR/Cas Subtype Ypest protein 4.	8.98612e-80
NC_012214.1\|WP_012667173.1\|946948_947311_+\|YacL-family-protein	gnl\|CDD\|235372	PRK05248, PRK05248, hypothetical protein; Provisional.	3.79668e-65
NC_012214.1\|WP_012667182.1\|957164_957461_+\|BrnA-antitoxin-family-protein	gnl\|CDD\|373040	pfam14384, BrnA_antitoxin, BrnA antitoxin of type II toxin-antitoxin system. BrnA is family of antitoxins that neutralizes the toxin BrnT, pfam04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerizes with two molecules of its toxin BrnT.	3.1888e-13
NC_012214.1\|WP_012667184.1\|959265_960210_+\|type-I-F-CRISPR-associated-protein-Csy2	gnl\|CDD\|378221	pfam09614, Cas_Csy2, CRISPR-associated protein (Cas_Csy2). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2464 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy2, for CRISPR/Cas Subtype Ypest protein 2.	2.38087e-144
NC_012214.1\|WP_012667188.1\|963973_965254_-\|cystathionine-gamma-synthase-family-protein	gnl\|CDD\|180809	PRK07049, PRK07049, cystathionine gamma-synthase family protein.	0
NC_012214.1\|WP_012667174.1\|947398_948202_-\|adenosylmethionine-decarboxylase	gnl\|CDD\|235480	PRK05462, PRK05462, adenosylmethionine decarboxylase.	0
NC_012214.1\|WP_012667180.1\|953514_956826_+\|type-I-F-CRISPR-associated-helicase-Cas3	gnl\|CDD\|274201	TIGR02562, conserved_hypothetical_protein, CRISPR-associated helicase Cas3, subtype I-F/YPEST. The helicase in many CRISPR-associated (cas) gene clusters is designated Cas3, and most Cas3 proteins are described by model TIGR01587. Members of this family are considerably larger, show a number of motifs in common with TIGR01587 sequences, and replace Cas3 in some CRISPR/cas loci in a number of Proteobacteria, including Yersinia pestis, Chromobacterium violaceum, Erwinia carotovora subsp. atroseptica SCRI1043, Photorhabdus luminescens subsp. laumondii TTO1, Legionella pneumophila, etc.	0
NC_012214.1\|WP_012667176.1\|949181_949529_-\|YacC-family-pilotin-like-protein	gnl\|CDD\|370620	pfam09691, T2SS_PulS_OutS, Type II secretion system pilotin lipoprotein (PulS_OutS). This family comprises lipoproteins from four gamma proteobacterial species: PulS protein of Klebsiella pneumoniae (P20440), the OutS protein of Erwinia chrysanthemi (Q01567) and Pectobacterium chrysanthemi, and the functionally uncharacterized E. coli protein EtpO. PulS and OutS have been shown to interact with and facilitate insertion of secretins into the outer membrane, suggesting a chaperone-like, or piloting function for members of this family. In the pilotin from this four-helix protein from enterohemorrhagic Escherichia coli, the straight helix alpha2, the curved helix alpha3 and the bent helix alpha4 surround the central N-terminal helix alpha1. These helices create a prominent groove, mainly formed by side chains of helices 1,2 and 3 suggesting this groove is important as a binding site.	3.19667e-09
NC_012214.1\|WP_012667185.1\|960233_961238_+\|type-I-F-CRISPR-associated-protein-Csy3	gnl\|CDD\|378222	pfam09615, Cas_Csy3, CRISPR-associated protein (Cas_Csy3). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2463 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy3, for CRISPR/Cas Subtype Ypest protein 3.	0
NC_012214.1\|WP_012667172.1\|944177_946775_+\|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase	gnl\|CDD\|236424	PRK09238, PRK09238, bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated.	0

>NC_012214.1|WP_012667177.1|949707_951303_+|multicopper-oxidase-CueO
MQRRDFIKLSAALGAAGALPVWSRALMAAEQRPLLPIPTLLTPDARSEISLTAQASSSGWRGWGYNANLPGPALQLERGKEVNITVYNRLPEATTVHWHGLEVPGDIDGGPQARIEPNHSRRVTFTPDQPAATCWFHPHQHGRTGFQVAQGLAGLVLIADPESGKLLLPKQWGIDDIPVVLQDKRLSADGSRIDYQLDIISAAVGWFGDTMLTNGAIYPQHGVPRGWLRLRLLNGCNARSLNLTTSDKRPMYVIASDGGLLGEPVQVSELPMMPGERYEVLVNTTDGKAFDLQTLPVRQMGMTLEPFNQPLPVLSLVPLLVQASGTLPDKLASLPAMPSSQGLNTRWLQLMMDPELDRRGMQALMDKYGHAAMAGISMDAHGGGKKAGANNHDMSSMDHGKMATMNHGSSAQQQEYDFHNGNQINGMAFNRDKPSFEVKRGVYEKWTISGEGDEMLHPFHIHGTQFRILSENGKPPAAHRSGWKDTVRVEGWRSEVLVRFNHPADRAHAYMAHCHLLEHEDTGMMLGFTVA
>NC_012214.1|WP_012667176.1|949181_949529_-|YacC-family-pilotin-like-protein
MKKSIKALLLSGLFGFTSTSFALSEPEAEDLADLTAVFVYLKNDCGYRDLPDAQIRRALVFFAQQNRWDLTNYSSFNMKALGEDSYRDLSGIAVPNDTKCKSLARDSLNLLAWVK
>NC_012214.1|WP_012667175.1|948223_949081_-|polyamine-aminopropyltransferase
MAANEMWYETLHAGFGQYFSVDKVVYREQTDHQDLIIFENAALGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGNAKRVLIIGGGDGAMLREVCRHKNIEQITMVEIDAGVVTFCKQYLPNHNAGAYADARFELVIDDGVNFVNQTSDKFDVIISDCTDPIGPGESLFTSEFYQGCRRCLHQDGIFVAQNGVCFLQQDEAVNSHRKLSHYFGDVSFYQAAIPTYYGGIMTFAWASDNPALRQLDTATLTARFTEAGLKCRYYNPAIHTGSFALPQYLLNALAN
>NC_012214.1|WP_012667174.1|947398_948202_-|adenosylmethionine-decarboxylase
MKLQKLKLHGFNNLTKSLSFCIYDICYANTEAERDGYIAYIDEQYNANRLTEILSETCSIIGANVLNIARQDYEPQGASVTILVSEEPIDPRDIDTSEHPGPLPNSVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDVNGVKHFIDHEINSIQNFMSEDMKSMYDMMDVNVYQENMFHTKMMLKEFDLKHYLFNTKPEELSAQEHKRITGLLWKEMREIYYGRNIPAFG
>NC_012214.1|WP_012667173.1|946948_947311_+|YacL-family-protein
MEYEFLSDITGAVKVRMSMGHEAVGHWFNDEVSGNPEILAEVEAAIAQVKGSERQWQRVGREYTLLLDEEEVMIRANQLGFEGDEMEEGMAYYDEESLSFCGVEDFLMVIAAYRAFLLGR
>NC_012214.1|WP_012667172.1|944177_946775_+|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase
MLEEYRKHVAERAAQGIVPKPLDASQMAALVELLKAPPAGEEEFLSDLLTNRVPPGVDEAAYVKAGFLAAVAKGEATSPLVTPEQAVELLGTMQGGYNIHALIDALDDEKLAPLAAESLSHTLLMFDNFYDVEDKAKAGNPHAKKIIQSWADAEWFLKRPKLAEKITVTVFKVTGETNTDDLSPAPDAWSRPDIPLHALAMLKNAREGIEPDDAGNVGPIKQIEHLQEKGFPLAYVGDVVGTGSSRKSATNSVLWFMGDDIPNVPNKKGGGVCLGGKIAPIFFNTMEDAGALPIEVDVDRLNMGDVIDIYPYKGEVRNHETGEVLANFALKTEVLLDEVRAGGRIPLIIGRGLTTKARESLGLPHSDVFLQAKDVAASTRGFSLAQKMVGRACGVEGVRPGAYCEPKMTSVGSQDTTGPMTRDELKDLACLGFSADLVMQSFCHTAAYPKPVDVTTHHTLPDFIMNRGGVSLRPGDGIIHSWLNRMLLPDTVGTGGDSHTRFPIGISFPAGSGLVAFAAATGVMPLDMPESVLVRFKGKMQPGITLRDLVHAIPLYAIKAGLLTVEKKGKKNIFSGRILEIEGLPDLKVEQAFELSDASAERSAAGCTIKLGKDPIIEYLNSNIVLLKWMISEGYGDRRTIERRIQGMEKWLTDPQLLEGDADAEYAAVIDIDLAEIKEPILCAPNDPDDARLLSDVQGTKIDEVFIGSCMTNIGHFRAAGKLLDSHKGQLPTRLWVAPPTKMDAAQLTEEGYYSVFGKSGARIEIPGCSLCMGNQARVADGATVVSTSTRNFPNRLGTGANVYLASAELSAVASLLGKLPTPAEYQAFMDQVDKTAVDTYRYLNFDQLTQYTDKADAVIFQTAV
>NC_012214.1|WP_012667170.1|942655_943405_-|toxin-transcriptional-activator-ToxR
MRVYFEPENCILSNDKMSIKITLQEGRCLDYLVKNEGKFIRREKLLEECWIKRGVTVSDSAVRQSLYRLRRAFEDAGLPPSTLTTQARKGHILQEGSIILLTAHASHNCVDIESSVPSMKKQGTYRHTHLYSTVTSLLPFAKFASLFVIFFLAGLYTRQQIMITEVNYHQAEEKEGRFYFYRKNQAPYESAASKINYWLDNKLVNASDMKYVYLNNSWAGNTSFYLCNEEIGSEGSHCTSVTVKGDYHS
>NC_012214.1|WP_012667169.1|942188_942659_-|hypothetical-protein
MRRCYFFIAAVILFSCGWFFAPWIILSNMEDCISKSIIIYDEPDRYIISRSTWFTYRGGQEHRYSAQVSIGGPQGKIDEFSSERTIETERRFNYDSINVNTVKSFRIAGILTSDPRMGKYIDPPAKEGFTGQIHLFRYRDSCILAGLKGGPLSICQ
>NC_012214.1|WP_012667168.1|940840_941125_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MSMLVVITENVPPRLRGRLAVWLLEVRAGVYVGDVSRRVREMIWQQLDQLYEEGNVAMVWATNSESGFEFQTLGENRRLPVDLDGLRLVSFYPV
>NC_012214.1|WP_012667167.1|939897_940839_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MSFVPLTPLPLKDRVSLVFLKYGQIDVLDGAFVLIDKTGVRTHIPVGSIACIMLEPGTRVSHAAVRLAATVGTLLVWVGEAGVRLYASGQPGGARSDKLLYQAKLALDSDLRLKVVRKMFALRFGEEAPARRSVEQLRGIEGGRVKATYALLAKQYGVEWHGRRYDIKDWDKGDMINQCISAATACLYGVTEAAMLAAGYAPAIGFVHSGKPLSFVYDIADIIKFDTVVPAAFAIAAARPPDAEKKVRLACRDAFRSGRILGKLIPLIETVLAAGEISPPPPPPPPPPPPPPDAQPVAIPEPQSLGDAGHRSS
>NC_012214.1|WP_012667179.1|952540_953518_+|type-I-F-CRISPR-associated-endonuclease-Cas1
MEMIKPSDLKTILHSKRSNIYYLQYCRVLVNGGRVEYVTDEGKQSLYWNIPIANTTVVMLGTGTSVTQAAMREFARAGVLVGFCGGGGTPLYAANEVEVDVSWLNSQSEYRPTEYLQHWVSFWFDEQKRLSAAIAFQHVRISQIRQAWLGSKMMREHKFAISEPQLTGILDRFEQGLARCNNNTDLLALEAVMTKALYKLAAQAVSYGDFIRAKRGGGIDAANRFLDHGNYLAYGLAAVACWVIGLPHGLAVLHGKTRRGGLVFDVADLIKDALILPQAFLAAMAGEEEQEFRQRCLTSLQNAEALDTMIAALEATARQYSQVGK
>NC_012214.1|WP_012667180.1|953514_956826_+|type-I-F-CRISPR-associated-helicase-Cas3
MNILLIAQCNKRALEDSRRILDQFAERKGDRSWQTAITQQGLLTLRKLLRKTARRNTAVACHWIKSNGQSELLWIVGNLRRFNAQGAVPTHTTSRDVLKSADENSWHSVEAVSLLAAIAGLFHDFGKANSLFQQMLVGKKGVKSFQPYRHEWVSLRLFCAWVAGRDDRAWIAALSDIGPQDEQAMLAGLQKDGLMPTKNPFDPLPPVARVVAWLILSHHRMPVYPKKDDLPPQMTWLPPELEHCDGWLTRELDALWNALNHHHDWKPAELQAQWQFPQGTPMQSGRWCGKARKMAQRLLAQPAWLAQIDINQRFSCHMARLALMLADHVYSRQAATPGWQDADCLPYANTDNGRPKQRLDEHNIGVAQNALLLARSLPHLRKTLPAIARHKGFKKRSENSTFRWQDNAWQATCNLRDRAFQQGFFGINMASTGCGKTFANARIMYALSDEQKGCRFAVALGLRTLTLQTGDALREKLKLEQDDLAVLVGSQAVTQLHQQAKDSPTPPVPGSESAAPLPEENQYVSYEGSLDDGRLSRWLKDSPRINKLLSAPVLVTTIDHLIGATEGLRGGKQIAPMLRLLTSDLVLDEPDDFDIEDQHALCRLVNWAGMLGSRVLLSSATLPPALVLALYNAYRSGREVFQHACGLPVDGNICCAWFDENAVLTEDLRLPQEFMQQHQEFVARRVSWLAKQPVLRRGWIAPVAPPARDDGTIYRHMAQVILQSMMTLHHAHHQRHPVSGKTISTGVIRLANINPLVAVAQQLLATGAAEDTHIHYCVYHSQHPLAMRSHFEQRLDATLTRHQPEAIWQVAEIAEALEQHPQQHHLFVVLATSVAEVGRDHDYDWAIAEPSSMRSLIQLAGRVQRHRQQEAQSENIHMLQQNIRSLKARDSQKPAYCQPGFEHKDYMLASHDLQQILDKEQYQTISAIPRIQQRREAKKRQPFTNLADLEHQRLMVELQGKQDKKDKQVKQDKPLPYCAALWWREQASWCGEMQRHKPFRQSQPEDMHFMLIAEEGDQPEIWQPDDGPSGRKQSMMTYPDLTFAAGISAWIAPDYQQVWQQLADSLTMELEEVSLRFGEIMLRSGRDDEIWHFHPLLGVFKAQ
>NC_012214.1|WP_012667181.1|956899_957178_+|BrnT-family-toxin
MDICYDPDKDVKNRRKHGYSLADSALLDWDEMVVYEDNRQPYDEIRLIGLTYGLARLGNRIFSVCFTEHEEVYRIISLRLATRKEIQRYAET
>NC_012214.1|WP_012667182.1|957164_957461_+|BrnA-antitoxin-family-protein
MPKLKPGTVFPSAEEDAKIYAAVADDEDSMLLEDPQLKLTPLKKRGRPQKAQPKIAVSVRYTPEVISAFKASGAGWQTRMDVALQDWLKTHRPTEIKL
>NC_012214.1|WP_012667183.1|957919_959269_+|type-I-F-CRISPR-associated-protein-Csy1
MLRETLASFITSYIAARKTAKLEAFDKESAKKLAALASEDQISVLRQQLQQQRAELEQKYQPQAWLSDAASRAGQINLVTHAAKFTHSDARGSSIFASSSVQHEMYLSTAALQKPALDVVGNAAILDVAKLLQTEVEGNSLIASLQRGDYSALESLTDNPELCASWVNGFKQVLVDRQPASHKLAKQIYFPIADGQYHLLSPLFSSALAHALNQRIISAKFSEEAKTARAALKAKSWHDGPVVAYPGTAITQFGGTKPQNISYLNSVRGGKVWLLPCAPPVWQTQSQPPSQHKSIFNFSNDFSRQSWPVIQRLKHFLRRVKTLDSTLDIRQQRLAMTDEIIDILFNYVAGLQNQTDLRGWSAHPDCVLKRSQQLWLDPWRSQDDAEFQFEREGGDWKNEVARDFGHWLSRHLHSDKLNMGETERRHFSTAPLFKQRLRELEKDLAEDLS
>NC_012214.1|WP_012667184.1|959265_960210_+|type-I-F-CRISPR-associated-protein-Csy2
MSALIVLRHLRVENANAIAGLTWGFPAITHFLGFTHALSRKLQQSHNITLSGCGVICHQQQVHAYTSGQDYWFALTRNPLTKEAKIAAFNEEGRMHMTVSLLVECHGSIVGGEQGAAELMQTLANLCQRFRLAGGTVTSVGQVQISGWPQDDGETRRIMRRLLPGFALLDRSALLAAHHSQPPQAEMLDTWLDFAALKMQADDGATPADGNVQWQYQPKPGTGYLVPLMTGYRAISPLCPPGEVANSRDNETPFRFTEAVYGVGEWRGLHRIDDLRHLLWRYHHQDEYYLCRSEETACDQDYPDDDEDDDINYN
>NC_012214.1|WP_012667185.1|960233_961238_+|type-I-F-CRISPR-associated-protein-Csy3
MAKSAIKTASVLAFERKLSNSDAIMLAGKWQDEQNWTPIKIQEKAVRGTISNRLKNAIASDPLKLDAEIQKPNLQRVDVAALPYNCDSLKVCFTLRVLSGLATPAVCNDRAYQAALAAVIDGYIARHGFSTLAARYAENIANGRFLWRNRLGAGRIAVQVTSGEKCWQFDSYDYSLQAFSQPQGDLLELAQAIEQGLSGNSFALFNVEARVYLGNGQEVFPSQELVLDGNSKKSKLLYQIDGTAAIHSQKIGNALRTIDSWYPDADELDEGPISVEPYGSVTSRGIAYRQPIKKMDFYNLLDNWVTKDKEPDTEQQHYVMAILIRGGVFGEKSE
>NC_012214.1|WP_012667186.1|961246_961801_+|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4
MDHYQDIRVRVDEENGEAVLLAQVFMHLHQVLMRAANGRIGISFPNVKRTLGDRIRLHGTLDDLSALQQSGWNKCLRDYIACSDIAPVPKGAAWRTVRRVQVKSSAERLRRRSVNKGWLSEQEAAERISVLNEQRSNLPFLQIKSGSNGQAWRLFIEHGSLVSAPSDGSFSSYGLSAAATIPWF
>NC_012214.1|WP_012667187.1|962981_963659_+|helix-turn-helix-transcriptional-regulator
MNIYTQKLSSRKKVVLVTDDRYFYLGIKSASMSNLAITALGFDRFMDESVSADALVVVDMLSWAFFKPSNETSFYEKMIKNKKPEDVVMLTSNIFQEVITDMLYPGLCKVDRKLSLSFFSELSANKIRRNSARWCPAFAKKRGLTNREMNIILELFRGGKEDEISMQLNICQKTVSAHKLSALSKVGCKNISHFFLLGRPFYRDLKFLLSPRRNSLSGEGFSVSQ
>NC_012214.1|WP_012667188.1|963973_965254_-|cystathionine-gamma-synthase-family-protein
MSSSHSKKTHIGQRELQPETQMLNYGYDPALSEGAVKPPVFLTSTFVFNSAEEGRDFFDYVSGRREPPAGEGNGLVYSRFNHPNSEIVEDRLAIYERSESAALFSSGMSAIATTLLTFVRPGDAILHSQPLYGGSETLLGKTFGNLGVAAVGFADGIDEASVQAAADKALAKGRVSAILIESPANPTNSLVDIALMKRVADRIERQQQHRPVIACDNTLLGPLFSRPLEHGADISLYSLTKYVGGHSDLIAGAAMGNQALIRQVKALRSAIGTQLDPHSSWMIGRSLETLALRMERAGDNAAAVAEFLRSHPQVEQIHYLPFLCPDSAAGKIYSAQCSGAGSTFSFDICGGQDAAFRFLNGLQLFKLAVSLGGTESLASHPASTTHSGVDAAVRERIGIKASTIRLSIGIENKDDLIEDLRLALNK

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Crispr_ID: NC_012214_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012214_4

951489-952117

TypeI-E,TypeI-F

I-F

Consensus_repeat	Method
GTTCACTGCCGCACAGGCAGCTTAGAAA	PILER-CR
GTTCACTGCCGCACAGGCAGCTTAGAAA	CRISPRCasFinder
GTTCACTGCCGCACAGGCAGCTTAGAAA	CRT

10 spacers

cas2,cas1,cas3f,cas8f,cas5f,cas7f,cas6f

The CRISPR arrays of NC_012214_4

>merge|NC_012214|4|951489-952117|PILER-CR,CRISPRCasFinder,CRT
GTTCACTGCCGCACAGGCAGCTTAGAAAATCACCGCTTCCCCCCTACCTTTGCAGTCTCGGTTCACTGCCGCACAGGCAGCTTAGAAATGCCGGACAGCGTGATGATTTTCAATAAACCAGTTCACTGCCGCACAGGCAGCTTAGAAAGTTCCAGGCTTGCCGCACATCACCAGCCCACCGTTCACTGCCGCACAGGCAGCTTAGAAAATTGACGAAATTTTGACAACGCTGAAACTGCCGTTCACTGCCGCACAGGCAGCTTAGAAACCCGTTGTGGCTCAAAGCCGGAGATCAGCACCGTTCACTGCCGCACAGGCAGCTTAGAAATCTACGGCGAGTAGAAAATAACTATCAAGCAGGTTCACTGCCGCACAGGCAGCTTAGAAAGGAAACGAACAGCGTTTTCCACTGCATTAATGGTTCACTGCCGCACAGGCAGCTTAGAAACATTCGTCTTGCCATCTCTTCGACCGGCAGCAGTTCACTGCCGTACAGGCAGCTTAGAAACGGGATAGCGCCGGGAAAATCAGTTGCAACGCGTTCACTGCCGTACAGGCAGCCTAGAAACTGAAACCGTCAGGTTCCGGGTACTTTTTCTTGTTCACTGCCGCACTGCCAGCTTAGAAAT

>NC_012214|4|4|951489-951996|PILER-CR
GTTCACTGCCGCACAGGCAGCTTAGAAA	ATCACCGCTTCCCCCCTACCTTTGCAGTCTCG
GTTCACTGCCGCACAGGCAGCTTAGAAA	TGCCGGACAGCGTGATGATTTTCAATAAACCA
GTTCACTGCCGCACAGGCAGCTTAGAAA	GTTCCAGGCTTGCCGCACATCACCAGCCCACC
GTTCACTGCCGCACAGGCAGCTTAGAAA	ATTGACGAAATTTTGACAACGCTGAAACTGCC
GTTCACTGCCGCACAGGCAGCTTAGAAA	CCCGTTGTGGCTCAAAGCCGGAGATCAGCACC
GTTCACTGCCGCACAGGCAGCTTAGAAA	TCTACGGCGAGTAGAAAATAACTATCAAGCAG
GTTCACTGCCGCACAGGCAGCTTAGAAA	GGAAACGAACAGCGTTTTCCACTGCATTAATG
GTTCACTGCCGCACAGGCAGCTTAGAAA	CATTCGTCTTGCCATCTCTTCGACCGGCAGCA
GTTCACTGCCGTACAGGCAGCTTAGAAA

>NC_012214|4|4|951489-952117|CRISPRCasFinder
GTTCACTGCCGCACAGGCAGCTTAGAAA	ATCACCGCTTCCCCCCTACCTTTGCAGTCTCG
GTTCACTGCCGCACAGGCAGCTTAGAAA	TGCCGGACAGCGTGATGATTTTCAATAAACCA
GTTCACTGCCGCACAGGCAGCTTAGAAA	GTTCCAGGCTTGCCGCACATCACCAGCCCACC
GTTCACTGCCGCACAGGCAGCTTAGAAA	ATTGACGAAATTTTGACAACGCTGAAACTGCC
GTTCACTGCCGCACAGGCAGCTTAGAAA	CCCGTTGTGGCTCAAAGCCGGAGATCAGCACC
GTTCACTGCCGCACAGGCAGCTTAGAAA	TCTACGGCGAGTAGAAAATAACTATCAAGCAG
GTTCACTGCCGCACAGGCAGCTTAGAAA	GGAAACGAACAGCGTTTTCCACTGCATTAATG
GTTCACTGCCGCACAGGCAGCTTAGAAA	CATTCGTCTTGCCATCTCTTCGACCGGCAGCA
GTTCACTGCCGTACAGGCAGCTTAGAAA	CGGGATAGCGCCGGGAAAATCAGTTGCAACGC
GTTCACTGCCGTACAGGCAGCCTAGAAA	CTGAAACCGTCAGGTTCCGGGTACTTTTTCTT
GTTCACTGCCGCACTGCCAGCTTAGAAAT

>NC_012214|4|3|951489-952116|CRT
GTTCACTGCCGCACAGGCAGCTTAGAAA	ATCACCGCTTCCCCCCTACCTTTGCAGTCTCG
GTTCACTGCCGCACAGGCAGCTTAGAAA	TGCCGGACAGCGTGATGATTTTCAATAAACCA
GTTCACTGCCGCACAGGCAGCTTAGAAA	GTTCCAGGCTTGCCGCACATCACCAGCCCACC
GTTCACTGCCGCACAGGCAGCTTAGAAA	ATTGACGAAATTTTGACAACGCTGAAACTGCC
GTTCACTGCCGCACAGGCAGCTTAGAAA	CCCGTTGTGGCTCAAAGCCGGAGATCAGCACC
GTTCACTGCCGCACAGGCAGCTTAGAAA	TCTACGGCGAGTAGAAAATAACTATCAAGCAG
GTTCACTGCCGCACAGGCAGCTTAGAAA	GGAAACGAACAGCGTTTTCCACTGCATTAATG
GTTCACTGCCGCACAGGCAGCTTAGAAA	CATTCGTCTTGCCATCTCTTCGACCGGCAGCA
GTTCACTGCCGTACAGGCAGCTTAGAAA	CGGGATAGCGCCGGGAAAATCAGTTGCAACGC
GTTCACTGCCGTACAGGCAGCCTAGAAA	CTGAAACCGTCAGGTTCCGGGTACTTTTTCTT
GTTCACTGCCGCACTGCCAGCTTAGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012214.1\|WP_012667177.1\|949707_951303_+\|multicopper-oxidase-CueO	unknown	unknown	gnl\|CDD\|236810
NC_012214.1\|WP_012667167.1\|939897_940839_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NC_012214.1\|WP_012667181.1\|956899_957178_+\|BrnT-family-toxin	unknown	unknown	gnl\|CDD\|367913
NC_012214.1\|WP_012667175.1\|948223_949081_-\|polyamine-aminopropyltransferase	unknown	unknown	gnl\|CDD\|234843
NC_012214.1\|WP_012667183.1\|957919_959269_+\|type-I-F-CRISPR-associated-protein-Csy1	cas8f	cd09735_cas8f_CAS-I-F	gnl\|CDD\|187866
NC_012214.1\|WP_012667187.1\|962981_963659_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NC_012214.1\|WP_012667168.1\|940840_941125_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	cd09648_cas2_CAS-I-E	gnl\|CDD\|236930
NC_012214.1\|WP_012667179.1\|952540_953518_+\|type-I-F-CRISPR-associated-endonuclease-Cas1	cas1	cd09718_cas1_CAS-I-F	gnl\|CDD\|132676
NC_012214.1\|WP_012667170.1\|942655_943405_-\|toxin-transcriptional-activator-ToxR	unknown	unknown	gnl\|CDD\|226233
NC_012214.1\|WP_012667169.1\|942188_942659_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_012667186.1\|961246_961801_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	cas6f	cd09739_cas6f_CAS-I-F:CAS-IV	gnl\|CDD\|378224
NC_012214.1\|WP_012667173.1\|946948_947311_+\|YacL-family-protein	unknown	unknown	gnl\|CDD\|235372
NC_012214.1\|WP_012667182.1\|957164_957461_+\|BrnA-antitoxin-family-protein	unknown	unknown	gnl\|CDD\|373040
NC_012214.1\|WP_012667184.1\|959265_960210_+\|type-I-F-CRISPR-associated-protein-Csy2	cas5f	cd09676_cas5f_CAS-I-F	gnl\|CDD\|378221
NC_012214.1\|WP_012667188.1\|963973_965254_-\|cystathionine-gamma-synthase-family-protein	unknown	unknown	gnl\|CDD\|180809
NC_012214.1\|WP_012667174.1\|947398_948202_-\|adenosylmethionine-decarboxylase	unknown	unknown	gnl\|CDD\|235480
NC_012214.1\|WP_012667180.1\|953514_956826_+\|type-I-F-CRISPR-associated-helicase-Cas3	cas3f	cd09673_cas3f_CAS-I-F	gnl\|CDD\|274201
NC_012214.1\|WP_012667176.1\|949181_949529_-\|YacC-family-pilotin-like-protein	unknown	unknown	gnl\|CDD\|370620
NC_012214.1\|WP_012667185.1\|960233_961238_+\|type-I-F-CRISPR-associated-protein-Csy3	cas7f	pfam09615_cas7f_CAS-I-F	gnl\|CDD\|378222
NC_012214.1\|WP_012667172.1\|944177_946775_+\|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase	unknown	unknown	gnl\|CDD\|236424

Protein	Function_ID	Function_description	E-value
NC_012214.1\|WP_012667177.1\|949707_951303_+\|multicopper-oxidase-CueO	gnl\|CDD\|236810	PRK10965, PRK10965, multicopper oxidase; Provisional.	0
NC_012214.1\|WP_012667167.1\|939897_940839_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	2.20885e-148
NC_012214.1\|WP_012667181.1\|956899_957178_+\|BrnT-family-toxin	gnl\|CDD\|367913	pfam04365, BrnT_toxin, Ribonuclease toxin, BrnT, of type II toxin-antitoxin system. BrnT is a ribonuclease toxin of a type II toxin-antitoxin system that exhibits a RelE-like fold. The antitoxin that neutralizes this toxin is pfam14384. BrnT is found in bacteria, archaea, bacteriophage, and plasmids. BrnT-BrnA forms a 2:2 tetrameric complex and autoregulates its own expression, which is induced by a number of different environmental stresses. Expression of BrnT alone results in cessation of bacterial growth which can be rescued after subsequent expression of BrnA.	4.35797e-20
NC_012214.1\|WP_012667175.1\|948223_949081_-\|polyamine-aminopropyltransferase	gnl\|CDD\|234843	PRK00811, PRK00811, polyamine aminopropyltransferase.	0
NC_012214.1\|WP_012667183.1\|957919_959269_+\|type-I-F-CRISPR-associated-protein-Csy1	gnl\|CDD\|187866	cd09735, Csy1_I-F, CRISPR/Cas system-associated protein Csy1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins; Predicted subunit of the Cascade complex; signature gene for I-F subtype; also known as Csy1 family.	4.72601e-173
NC_012214.1\|WP_012667187.1\|962981_963659_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	4.5748e-10
NC_012214.1\|WP_012667168.1\|940840_941125_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|236930	PRK11558, PRK11558, putative ssRNA endonuclease; Provisional.	1.21933e-60
NC_012214.1\|WP_012667179.1\|952540_953518_+\|type-I-F-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|132676	TIGR03637, cas1_YPEST, CRISPR-associated endonuclease Cas1, subtype I-F/YPEST. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the YPEST subtype of CRISPR/Cas system.	0
NC_012214.1\|WP_012667170.1\|942655_943405_-\|toxin-transcriptional-activator-ToxR	gnl\|CDD\|226233	COG3710, CadC, DNA-binding winged-HTH domains [Transcription].	8.12936e-16
NC_012214.1\|WP_012667186.1\|961246_961801_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	gnl\|CDD\|378224	pfam09618, Cas_Csy4, CRISPR-associated protein (Cas_Csy4). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family, typified by YPO2462 of Yersinia pestis, is a CRISPR-associated (Cas) family strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy4, for CRISPR/Cas Subtype Ypest protein 4.	8.98612e-80
NC_012214.1\|WP_012667173.1\|946948_947311_+\|YacL-family-protein	gnl\|CDD\|235372	PRK05248, PRK05248, hypothetical protein; Provisional.	3.79668e-65
NC_012214.1\|WP_012667182.1\|957164_957461_+\|BrnA-antitoxin-family-protein	gnl\|CDD\|373040	pfam14384, BrnA_antitoxin, BrnA antitoxin of type II toxin-antitoxin system. BrnA is family of antitoxins that neutralizes the toxin BrnT, pfam04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerizes with two molecules of its toxin BrnT.	3.1888e-13
NC_012214.1\|WP_012667184.1\|959265_960210_+\|type-I-F-CRISPR-associated-protein-Csy2	gnl\|CDD\|378221	pfam09614, Cas_Csy2, CRISPR-associated protein (Cas_Csy2). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2464 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy2, for CRISPR/Cas Subtype Ypest protein 2.	2.38087e-144
NC_012214.1\|WP_012667188.1\|963973_965254_-\|cystathionine-gamma-synthase-family-protein	gnl\|CDD\|180809	PRK07049, PRK07049, cystathionine gamma-synthase family protein.	0
NC_012214.1\|WP_012667174.1\|947398_948202_-\|adenosylmethionine-decarboxylase	gnl\|CDD\|235480	PRK05462, PRK05462, adenosylmethionine decarboxylase.	0
NC_012214.1\|WP_012667180.1\|953514_956826_+\|type-I-F-CRISPR-associated-helicase-Cas3	gnl\|CDD\|274201	TIGR02562, conserved_hypothetical_protein, CRISPR-associated helicase Cas3, subtype I-F/YPEST. The helicase in many CRISPR-associated (cas) gene clusters is designated Cas3, and most Cas3 proteins are described by model TIGR01587. Members of this family are considerably larger, show a number of motifs in common with TIGR01587 sequences, and replace Cas3 in some CRISPR/cas loci in a number of Proteobacteria, including Yersinia pestis, Chromobacterium violaceum, Erwinia carotovora subsp. atroseptica SCRI1043, Photorhabdus luminescens subsp. laumondii TTO1, Legionella pneumophila, etc.	0
NC_012214.1\|WP_012667176.1\|949181_949529_-\|YacC-family-pilotin-like-protein	gnl\|CDD\|370620	pfam09691, T2SS_PulS_OutS, Type II secretion system pilotin lipoprotein (PulS_OutS). This family comprises lipoproteins from four gamma proteobacterial species: PulS protein of Klebsiella pneumoniae (P20440), the OutS protein of Erwinia chrysanthemi (Q01567) and Pectobacterium chrysanthemi, and the functionally uncharacterized E. coli protein EtpO. PulS and OutS have been shown to interact with and facilitate insertion of secretins into the outer membrane, suggesting a chaperone-like, or piloting function for members of this family. In the pilotin from this four-helix protein from enterohemorrhagic Escherichia coli, the straight helix alpha2, the curved helix alpha3 and the bent helix alpha4 surround the central N-terminal helix alpha1. These helices create a prominent groove, mainly formed by side chains of helices 1,2 and 3 suggesting this groove is important as a binding site.	3.19667e-09
NC_012214.1\|WP_012667185.1\|960233_961238_+\|type-I-F-CRISPR-associated-protein-Csy3	gnl\|CDD\|378222	pfam09615, Cas_Csy3, CRISPR-associated protein (Cas_Csy3). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2463 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy3, for CRISPR/Cas Subtype Ypest protein 3.	0
NC_012214.1\|WP_012667172.1\|944177_946775_+\|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase	gnl\|CDD\|236424	PRK09238, PRK09238, bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated.	0

>NC_012214.1|WP_012667177.1|949707_951303_+|multicopper-oxidase-CueO
MQRRDFIKLSAALGAAGALPVWSRALMAAEQRPLLPIPTLLTPDARSEISLTAQASSSGWRGWGYNANLPGPALQLERGKEVNITVYNRLPEATTVHWHGLEVPGDIDGGPQARIEPNHSRRVTFTPDQPAATCWFHPHQHGRTGFQVAQGLAGLVLIADPESGKLLLPKQWGIDDIPVVLQDKRLSADGSRIDYQLDIISAAVGWFGDTMLTNGAIYPQHGVPRGWLRLRLLNGCNARSLNLTTSDKRPMYVIASDGGLLGEPVQVSELPMMPGERYEVLVNTTDGKAFDLQTLPVRQMGMTLEPFNQPLPVLSLVPLLVQASGTLPDKLASLPAMPSSQGLNTRWLQLMMDPELDRRGMQALMDKYGHAAMAGISMDAHGGGKKAGANNHDMSSMDHGKMATMNHGSSAQQQEYDFHNGNQINGMAFNRDKPSFEVKRGVYEKWTISGEGDEMLHPFHIHGTQFRILSENGKPPAAHRSGWKDTVRVEGWRSEVLVRFNHPADRAHAYMAHCHLLEHEDTGMMLGFTVA
>NC_012214.1|WP_012667176.1|949181_949529_-|YacC-family-pilotin-like-protein
MKKSIKALLLSGLFGFTSTSFALSEPEAEDLADLTAVFVYLKNDCGYRDLPDAQIRRALVFFAQQNRWDLTNYSSFNMKALGEDSYRDLSGIAVPNDTKCKSLARDSLNLLAWVK
>NC_012214.1|WP_012667175.1|948223_949081_-|polyamine-aminopropyltransferase
MAANEMWYETLHAGFGQYFSVDKVVYREQTDHQDLIIFENAALGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGNAKRVLIIGGGDGAMLREVCRHKNIEQITMVEIDAGVVTFCKQYLPNHNAGAYADARFELVIDDGVNFVNQTSDKFDVIISDCTDPIGPGESLFTSEFYQGCRRCLHQDGIFVAQNGVCFLQQDEAVNSHRKLSHYFGDVSFYQAAIPTYYGGIMTFAWASDNPALRQLDTATLTARFTEAGLKCRYYNPAIHTGSFALPQYLLNALAN
>NC_012214.1|WP_012667174.1|947398_948202_-|adenosylmethionine-decarboxylase
MKLQKLKLHGFNNLTKSLSFCIYDICYANTEAERDGYIAYIDEQYNANRLTEILSETCSIIGANVLNIARQDYEPQGASVTILVSEEPIDPRDIDTSEHPGPLPNSVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDVNGVKHFIDHEINSIQNFMSEDMKSMYDMMDVNVYQENMFHTKMMLKEFDLKHYLFNTKPEELSAQEHKRITGLLWKEMREIYYGRNIPAFG
>NC_012214.1|WP_012667173.1|946948_947311_+|YacL-family-protein
MEYEFLSDITGAVKVRMSMGHEAVGHWFNDEVSGNPEILAEVEAAIAQVKGSERQWQRVGREYTLLLDEEEVMIRANQLGFEGDEMEEGMAYYDEESLSFCGVEDFLMVIAAYRAFLLGR
>NC_012214.1|WP_012667172.1|944177_946775_+|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase
MLEEYRKHVAERAAQGIVPKPLDASQMAALVELLKAPPAGEEEFLSDLLTNRVPPGVDEAAYVKAGFLAAVAKGEATSPLVTPEQAVELLGTMQGGYNIHALIDALDDEKLAPLAAESLSHTLLMFDNFYDVEDKAKAGNPHAKKIIQSWADAEWFLKRPKLAEKITVTVFKVTGETNTDDLSPAPDAWSRPDIPLHALAMLKNAREGIEPDDAGNVGPIKQIEHLQEKGFPLAYVGDVVGTGSSRKSATNSVLWFMGDDIPNVPNKKGGGVCLGGKIAPIFFNTMEDAGALPIEVDVDRLNMGDVIDIYPYKGEVRNHETGEVLANFALKTEVLLDEVRAGGRIPLIIGRGLTTKARESLGLPHSDVFLQAKDVAASTRGFSLAQKMVGRACGVEGVRPGAYCEPKMTSVGSQDTTGPMTRDELKDLACLGFSADLVMQSFCHTAAYPKPVDVTTHHTLPDFIMNRGGVSLRPGDGIIHSWLNRMLLPDTVGTGGDSHTRFPIGISFPAGSGLVAFAAATGVMPLDMPESVLVRFKGKMQPGITLRDLVHAIPLYAIKAGLLTVEKKGKKNIFSGRILEIEGLPDLKVEQAFELSDASAERSAAGCTIKLGKDPIIEYLNSNIVLLKWMISEGYGDRRTIERRIQGMEKWLTDPQLLEGDADAEYAAVIDIDLAEIKEPILCAPNDPDDARLLSDVQGTKIDEVFIGSCMTNIGHFRAAGKLLDSHKGQLPTRLWVAPPTKMDAAQLTEEGYYSVFGKSGARIEIPGCSLCMGNQARVADGATVVSTSTRNFPNRLGTGANVYLASAELSAVASLLGKLPTPAEYQAFMDQVDKTAVDTYRYLNFDQLTQYTDKADAVIFQTAV
>NC_012214.1|WP_012667170.1|942655_943405_-|toxin-transcriptional-activator-ToxR
MRVYFEPENCILSNDKMSIKITLQEGRCLDYLVKNEGKFIRREKLLEECWIKRGVTVSDSAVRQSLYRLRRAFEDAGLPPSTLTTQARKGHILQEGSIILLTAHASHNCVDIESSVPSMKKQGTYRHTHLYSTVTSLLPFAKFASLFVIFFLAGLYTRQQIMITEVNYHQAEEKEGRFYFYRKNQAPYESAASKINYWLDNKLVNASDMKYVYLNNSWAGNTSFYLCNEEIGSEGSHCTSVTVKGDYHS
>NC_012214.1|WP_012667169.1|942188_942659_-|hypothetical-protein
MRRCYFFIAAVILFSCGWFFAPWIILSNMEDCISKSIIIYDEPDRYIISRSTWFTYRGGQEHRYSAQVSIGGPQGKIDEFSSERTIETERRFNYDSINVNTVKSFRIAGILTSDPRMGKYIDPPAKEGFTGQIHLFRYRDSCILAGLKGGPLSICQ
>NC_012214.1|WP_012667168.1|940840_941125_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MSMLVVITENVPPRLRGRLAVWLLEVRAGVYVGDVSRRVREMIWQQLDQLYEEGNVAMVWATNSESGFEFQTLGENRRLPVDLDGLRLVSFYPV
>NC_012214.1|WP_012667167.1|939897_940839_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MSFVPLTPLPLKDRVSLVFLKYGQIDVLDGAFVLIDKTGVRTHIPVGSIACIMLEPGTRVSHAAVRLAATVGTLLVWVGEAGVRLYASGQPGGARSDKLLYQAKLALDSDLRLKVVRKMFALRFGEEAPARRSVEQLRGIEGGRVKATYALLAKQYGVEWHGRRYDIKDWDKGDMINQCISAATACLYGVTEAAMLAAGYAPAIGFVHSGKPLSFVYDIADIIKFDTVVPAAFAIAAARPPDAEKKVRLACRDAFRSGRILGKLIPLIETVLAAGEISPPPPPPPPPPPPPPDAQPVAIPEPQSLGDAGHRSS
>NC_012214.1|WP_012667179.1|952540_953518_+|type-I-F-CRISPR-associated-endonuclease-Cas1
MEMIKPSDLKTILHSKRSNIYYLQYCRVLVNGGRVEYVTDEGKQSLYWNIPIANTTVVMLGTGTSVTQAAMREFARAGVLVGFCGGGGTPLYAANEVEVDVSWLNSQSEYRPTEYLQHWVSFWFDEQKRLSAAIAFQHVRISQIRQAWLGSKMMREHKFAISEPQLTGILDRFEQGLARCNNNTDLLALEAVMTKALYKLAAQAVSYGDFIRAKRGGGIDAANRFLDHGNYLAYGLAAVACWVIGLPHGLAVLHGKTRRGGLVFDVADLIKDALILPQAFLAAMAGEEEQEFRQRCLTSLQNAEALDTMIAALEATARQYSQVGK
>NC_012214.1|WP_012667180.1|953514_956826_+|type-I-F-CRISPR-associated-helicase-Cas3
MNILLIAQCNKRALEDSRRILDQFAERKGDRSWQTAITQQGLLTLRKLLRKTARRNTAVACHWIKSNGQSELLWIVGNLRRFNAQGAVPTHTTSRDVLKSADENSWHSVEAVSLLAAIAGLFHDFGKANSLFQQMLVGKKGVKSFQPYRHEWVSLRLFCAWVAGRDDRAWIAALSDIGPQDEQAMLAGLQKDGLMPTKNPFDPLPPVARVVAWLILSHHRMPVYPKKDDLPPQMTWLPPELEHCDGWLTRELDALWNALNHHHDWKPAELQAQWQFPQGTPMQSGRWCGKARKMAQRLLAQPAWLAQIDINQRFSCHMARLALMLADHVYSRQAATPGWQDADCLPYANTDNGRPKQRLDEHNIGVAQNALLLARSLPHLRKTLPAIARHKGFKKRSENSTFRWQDNAWQATCNLRDRAFQQGFFGINMASTGCGKTFANARIMYALSDEQKGCRFAVALGLRTLTLQTGDALREKLKLEQDDLAVLVGSQAVTQLHQQAKDSPTPPVPGSESAAPLPEENQYVSYEGSLDDGRLSRWLKDSPRINKLLSAPVLVTTIDHLIGATEGLRGGKQIAPMLRLLTSDLVLDEPDDFDIEDQHALCRLVNWAGMLGSRVLLSSATLPPALVLALYNAYRSGREVFQHACGLPVDGNICCAWFDENAVLTEDLRLPQEFMQQHQEFVARRVSWLAKQPVLRRGWIAPVAPPARDDGTIYRHMAQVILQSMMTLHHAHHQRHPVSGKTISTGVIRLANINPLVAVAQQLLATGAAEDTHIHYCVYHSQHPLAMRSHFEQRLDATLTRHQPEAIWQVAEIAEALEQHPQQHHLFVVLATSVAEVGRDHDYDWAIAEPSSMRSLIQLAGRVQRHRQQEAQSENIHMLQQNIRSLKARDSQKPAYCQPGFEHKDYMLASHDLQQILDKEQYQTISAIPRIQQRREAKKRQPFTNLADLEHQRLMVELQGKQDKKDKQVKQDKPLPYCAALWWREQASWCGEMQRHKPFRQSQPEDMHFMLIAEEGDQPEIWQPDDGPSGRKQSMMTYPDLTFAAGISAWIAPDYQQVWQQLADSLTMELEEVSLRFGEIMLRSGRDDEIWHFHPLLGVFKAQ
>NC_012214.1|WP_012667181.1|956899_957178_+|BrnT-family-toxin
MDICYDPDKDVKNRRKHGYSLADSALLDWDEMVVYEDNRQPYDEIRLIGLTYGLARLGNRIFSVCFTEHEEVYRIISLRLATRKEIQRYAET
>NC_012214.1|WP_012667182.1|957164_957461_+|BrnA-antitoxin-family-protein
MPKLKPGTVFPSAEEDAKIYAAVADDEDSMLLEDPQLKLTPLKKRGRPQKAQPKIAVSVRYTPEVISAFKASGAGWQTRMDVALQDWLKTHRPTEIKL
>NC_012214.1|WP_012667183.1|957919_959269_+|type-I-F-CRISPR-associated-protein-Csy1
MLRETLASFITSYIAARKTAKLEAFDKESAKKLAALASEDQISVLRQQLQQQRAELEQKYQPQAWLSDAASRAGQINLVTHAAKFTHSDARGSSIFASSSVQHEMYLSTAALQKPALDVVGNAAILDVAKLLQTEVEGNSLIASLQRGDYSALESLTDNPELCASWVNGFKQVLVDRQPASHKLAKQIYFPIADGQYHLLSPLFSSALAHALNQRIISAKFSEEAKTARAALKAKSWHDGPVVAYPGTAITQFGGTKPQNISYLNSVRGGKVWLLPCAPPVWQTQSQPPSQHKSIFNFSNDFSRQSWPVIQRLKHFLRRVKTLDSTLDIRQQRLAMTDEIIDILFNYVAGLQNQTDLRGWSAHPDCVLKRSQQLWLDPWRSQDDAEFQFEREGGDWKNEVARDFGHWLSRHLHSDKLNMGETERRHFSTAPLFKQRLRELEKDLAEDLS
>NC_012214.1|WP_012667184.1|959265_960210_+|type-I-F-CRISPR-associated-protein-Csy2
MSALIVLRHLRVENANAIAGLTWGFPAITHFLGFTHALSRKLQQSHNITLSGCGVICHQQQVHAYTSGQDYWFALTRNPLTKEAKIAAFNEEGRMHMTVSLLVECHGSIVGGEQGAAELMQTLANLCQRFRLAGGTVTSVGQVQISGWPQDDGETRRIMRRLLPGFALLDRSALLAAHHSQPPQAEMLDTWLDFAALKMQADDGATPADGNVQWQYQPKPGTGYLVPLMTGYRAISPLCPPGEVANSRDNETPFRFTEAVYGVGEWRGLHRIDDLRHLLWRYHHQDEYYLCRSEETACDQDYPDDDEDDDINYN
>NC_012214.1|WP_012667185.1|960233_961238_+|type-I-F-CRISPR-associated-protein-Csy3
MAKSAIKTASVLAFERKLSNSDAIMLAGKWQDEQNWTPIKIQEKAVRGTISNRLKNAIASDPLKLDAEIQKPNLQRVDVAALPYNCDSLKVCFTLRVLSGLATPAVCNDRAYQAALAAVIDGYIARHGFSTLAARYAENIANGRFLWRNRLGAGRIAVQVTSGEKCWQFDSYDYSLQAFSQPQGDLLELAQAIEQGLSGNSFALFNVEARVYLGNGQEVFPSQELVLDGNSKKSKLLYQIDGTAAIHSQKIGNALRTIDSWYPDADELDEGPISVEPYGSVTSRGIAYRQPIKKMDFYNLLDNWVTKDKEPDTEQQHYVMAILIRGGVFGEKSE
>NC_012214.1|WP_012667186.1|961246_961801_+|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4
MDHYQDIRVRVDEENGEAVLLAQVFMHLHQVLMRAANGRIGISFPNVKRTLGDRIRLHGTLDDLSALQQSGWNKCLRDYIACSDIAPVPKGAAWRTVRRVQVKSSAERLRRRSVNKGWLSEQEAAERISVLNEQRSNLPFLQIKSGSNGQAWRLFIEHGSLVSAPSDGSFSSYGLSAAATIPWF
>NC_012214.1|WP_012667187.1|962981_963659_+|helix-turn-helix-transcriptional-regulator
MNIYTQKLSSRKKVVLVTDDRYFYLGIKSASMSNLAITALGFDRFMDESVSADALVVVDMLSWAFFKPSNETSFYEKMIKNKKPEDVVMLTSNIFQEVITDMLYPGLCKVDRKLSLSFFSELSANKIRRNSARWCPAFAKKRGLTNREMNIILELFRGGKEDEISMQLNICQKTVSAHKLSALSKVGCKNISHFFLLGRPFYRDLKFLLSPRRNSLSGEGFSVSQ
>NC_012214.1|WP_012667188.1|963973_965254_-|cystathionine-gamma-synthase-family-protein
MSSSHSKKTHIGQRELQPETQMLNYGYDPALSEGAVKPPVFLTSTFVFNSAEEGRDFFDYVSGRREPPAGEGNGLVYSRFNHPNSEIVEDRLAIYERSESAALFSSGMSAIATTLLTFVRPGDAILHSQPLYGGSETLLGKTFGNLGVAAVGFADGIDEASVQAAADKALAKGRVSAILIESPANPTNSLVDIALMKRVADRIERQQQHRPVIACDNTLLGPLFSRPLEHGADISLYSLTKYVGGHSDLIAGAAMGNQALIRQVKALRSAIGTQLDPHSSWMIGRSLETLALRMERAGDNAAAVAEFLRSHPQVEQIHYLPFLCPDSAAGKIYSAQCSGAGSTFSFDICGGQDAAFRFLNGLQLFKLAVSLGGTESLASHPASTTHSGVDAAVRERIGIKASTIRLSIGIENKDDLIEDLRLALNK

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Crispr_ID: NC_012214_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012214_6

961931-962258

TypeI-F

I-F

Consensus_repeat	Method
GTTCACTGCCGTACAGGCAGCTTAGAAA	PILER-CR
GTTCACTGCCGTACAGGCAGCTTA	CRISPRCasFinder
GTTCACTGCCGTACAGGCAGCTTAGAAA	CRT

5 spacers

cas6f,cas7f,cas5f,cas8f,cas3f,cas1

The CRISPR arrays of NC_012214_6

>merge|NC_012214|6|961931-962258|PILER-CR,CRISPRCasFinder,CRT
GTTCACTGCCGTACAGGCAGCTTAGAAATCGGCGCTGCCGCTGCTCAAACTCGCCGTGCTGTTCACTGCCGTACAGGCAGCTTAGAAAACCATCACTGACAGCGAAGCCCGGAATAAACCCTTCACTGCCGTACAGGCAGCTTAGAAAAGTCCCGGCACCACCTCAGCGCCCAGCCCTGTGTTCACTGCCGTACAGGCAGCTTAGAAAAGCTAGAGGGGGTAAATAGCGTGGACTACAGCGTTCACTGCCGTACAGGCAGCTTAGAAAAAGTCGCGAACAGATTTCGGGGGGTTTTTGCAGTTCACTGCCGCACAGGCAGCTTATTAA

>NC_012214|6|5|961931-962198|PILER-CR
GTTCACTGCCGTACAGGCAGCTTAGAAA	TCGGCGCTGCCGCTGCTCAAACTCGCCGTGCT
GTTCACTGCCGTACAGGCAGCTTAGAAA	ACCATCACTGACAGCGAAGCCCGGAATAAACC
CTTCACTGCCGTACAGGCAGCTTAGAAA	AGTCCCGGCACCACCTCAGCGCCCAGCCCTGT
GTTCACTGCCGTACAGGCAGCTTAGAAA	AGCTAGAGGGGGTAAATAGCGTGGACTACAGC
GTTCACTGCCGTACAGGCAGCTTAGAAA

>NC_012214|6|6|961931-962254|CRISPRCasFinder
GTTCACTGCCGTACAGGCAGCTTA	GAAATCGGCGCTGCCGCTGCTCAAACTCGCCGTGCT
GTTCACTGCCGTACAGGCAGCTTA	GAAAACCATCACTGACAGCGAAGCCCGGAATAAACC
CTTCACTGCCGTACAGGCAGCTTA	GAAAAGTCCCGGCACCACCTCAGCGCCCAGCCCTGT
GTTCACTGCCGTACAGGCAGCTTA	GAAAAGCTAGAGGGGGTAAATAGCGTGGACTACAGC
GTTCACTGCCGTACAGGCAGCTTA	GAAAAAGTCGCGAACAGATTTCGGGGGGTTTTTGCA
GTTCACTGCCGCACAGGCAGCTTA

>NC_012214|6|4|961931-962258|CRT
GTTCACTGCCGTACAGGCAGCTTAGAAA	TCGGCGCTGCCGCTGCTCAAACTCGCCGTGCT
GTTCACTGCCGTACAGGCAGCTTAGAAA	ACCATCACTGACAGCGAAGCCCGGAATAAACC
CTTCACTGCCGTACAGGCAGCTTAGAAA	AGTCCCGGCACCACCTCAGCGCCCAGCCCTGT
GTTCACTGCCGTACAGGCAGCTTAGAAA	AGCTAGAGGGGGTAAATAGCGTGGACTACAGC
GTTCACTGCCGTACAGGCAGCTTAGAAA	AAGTCGCGAACAGATTTCGGGGGGTTTTTGCA
GTTCACTGCCGCACAGGCAGCTTATTAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012214.1\|WP_012667184.1\|959265_960210_+\|type-I-F-CRISPR-associated-protein-Csy2	cas5f	cd09676_cas5f_CAS-I-F	gnl\|CDD\|378221
NC_012214.1\|WP_012667177.1\|949707_951303_+\|multicopper-oxidase-CueO	unknown	unknown	gnl\|CDD\|236810
NC_012214.1\|WP_012667181.1\|956899_957178_+\|BrnT-family-toxin	unknown	unknown	gnl\|CDD\|367913
NC_012214.1\|WP_012667195.1\|970110_970905_-\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234723
NC_012214.1\|WP_012667180.1\|953514_956826_+\|type-I-F-CRISPR-associated-helicase-Cas3	cas3f	cd09673_cas3f_CAS-I-F	gnl\|CDD\|274201
NC_012214.1\|WP_012667183.1\|957919_959269_+\|type-I-F-CRISPR-associated-protein-Csy1	cas8f	cd09735_cas8f_CAS-I-F	gnl\|CDD\|187866
NC_012214.1\|WP_012667187.1\|962981_963659_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NC_012214.1\|WP_012667179.1\|952540_953518_+\|type-I-F-CRISPR-associated-endonuclease-Cas1	cas1	cd09718_cas1_CAS-I-F	gnl\|CDD\|132676
NC_012214.1\|WP_012667193.1\|968796_969177_-\|aspartate-1-decarboxylase	unknown	unknown	gnl\|CDD\|180090
NC_012214.1\|WP_012667196.1\|970983_971463_-\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|182325
NC_012214.1\|WP_012667194.1\|969240_970095_-\|pantoate--beta-alanine-ligase	unknown	unknown	gnl\|CDD\|234741
NC_012214.1\|WP_012667182.1\|957164_957461_+\|BrnA-antitoxin-family-protein	unknown	unknown	gnl\|CDD\|373040
NC_012214.1\|WP_041474092.1\|966143_966806_-\|carbonate-dehydratase	unknown	unknown	gnl\|CDD\|182460
NC_012214.1\|WP_012667192.1\|967957_968728_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|237896
NC_012214.1\|WP_012667188.1\|963973_965254_-\|cystathionine-gamma-synthase-family-protein	unknown	unknown	gnl\|CDD\|180809
NC_012214.1\|WP_012667191.1\|967034_967961_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_012214.1\|WP_012667176.1\|949181_949529_-\|YacC-family-pilotin-like-protein	unknown	unknown	gnl\|CDD\|370620
NC_012214.1\|WP_012667185.1\|960233_961238_+\|type-I-F-CRISPR-associated-protein-Csy3	cas7f	pfam09615_cas7f_CAS-I-F	gnl\|CDD\|378222
NC_012214.1\|WP_012667186.1\|961246_961801_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	cas6f	cd09739_cas6f_CAS-I-F:CAS-IV	gnl\|CDD\|378224
NC_012214.1\|WP_012667189.1\|965507_966044_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|185321

Protein	Function_ID	Function_description	E-value
NC_012214.1\|WP_012667184.1\|959265_960210_+\|type-I-F-CRISPR-associated-protein-Csy2	gnl\|CDD\|378221	pfam09614, Cas_Csy2, CRISPR-associated protein (Cas_Csy2). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2464 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy2, for CRISPR/Cas Subtype Ypest protein 2.	2.38087e-144
NC_012214.1\|WP_012667177.1\|949707_951303_+\|multicopper-oxidase-CueO	gnl\|CDD\|236810	PRK10965, PRK10965, multicopper oxidase; Provisional.	0
NC_012214.1\|WP_012667181.1\|956899_957178_+\|BrnT-family-toxin	gnl\|CDD\|367913	pfam04365, BrnT_toxin, Ribonuclease toxin, BrnT, of type II toxin-antitoxin system. BrnT is a ribonuclease toxin of a type II toxin-antitoxin system that exhibits a RelE-like fold. The antitoxin that neutralizes this toxin is pfam14384. BrnT is found in bacteria, archaea, bacteriophage, and plasmids. BrnT-BrnA forms a 2:2 tetrameric complex and autoregulates its own expression, which is induced by a number of different environmental stresses. Expression of BrnT alone results in cessation of bacterial growth which can be rescued after subsequent expression of BrnA.	4.35797e-20
NC_012214.1\|WP_012667195.1\|970110_970905_-\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl\|CDD\|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	1.57067e-161
NC_012214.1\|WP_012667180.1\|953514_956826_+\|type-I-F-CRISPR-associated-helicase-Cas3	gnl\|CDD\|274201	TIGR02562, conserved_hypothetical_protein, CRISPR-associated helicase Cas3, subtype I-F/YPEST. The helicase in many CRISPR-associated (cas) gene clusters is designated Cas3, and most Cas3 proteins are described by model TIGR01587. Members of this family are considerably larger, show a number of motifs in common with TIGR01587 sequences, and replace Cas3 in some CRISPR/cas loci in a number of Proteobacteria, including Yersinia pestis, Chromobacterium violaceum, Erwinia carotovora subsp. atroseptica SCRI1043, Photorhabdus luminescens subsp. laumondii TTO1, Legionella pneumophila, etc.	0
NC_012214.1\|WP_012667183.1\|957919_959269_+\|type-I-F-CRISPR-associated-protein-Csy1	gnl\|CDD\|187866	cd09735, Csy1_I-F, CRISPR/Cas system-associated protein Csy1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins; Predicted subunit of the Cascade complex; signature gene for I-F subtype; also known as Csy1 family.	4.72601e-173
NC_012214.1\|WP_012667187.1\|962981_963659_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	4.5748e-10
NC_012214.1\|WP_012667179.1\|952540_953518_+\|type-I-F-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|132676	TIGR03637, cas1_YPEST, CRISPR-associated endonuclease Cas1, subtype I-F/YPEST. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the YPEST subtype of CRISPR/Cas system.	0
NC_012214.1\|WP_012667193.1\|968796_969177_-\|aspartate-1-decarboxylase	gnl\|CDD\|180090	PRK05449, PRK05449, aspartate alpha-decarboxylase; Provisional.	2.30663e-75
NC_012214.1\|WP_012667196.1\|970983_971463_-\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|182325	PRK10239, PRK10239, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.	1.51613e-82
NC_012214.1\|WP_012667194.1\|969240_970095_-\|pantoate--beta-alanine-ligase	gnl\|CDD\|234741	PRK00380, panC, pantoate--beta-alanine ligase; Reviewed.	5.6787e-167
NC_012214.1\|WP_012667182.1\|957164_957461_+\|BrnA-antitoxin-family-protein	gnl\|CDD\|373040	pfam14384, BrnA_antitoxin, BrnA antitoxin of type II toxin-antitoxin system. BrnA is family of antitoxins that neutralizes the toxin BrnT, pfam04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerizes with two molecules of its toxin BrnT.	3.1888e-13
NC_012214.1\|WP_041474092.1\|966143_966806_-\|carbonate-dehydratase	gnl\|CDD\|182460	PRK10437, PRK10437, carbonic anhydrase; Provisional.	8.32545e-164
NC_012214.1\|WP_012667192.1\|967957_968728_+\|ABC-transporter-permease	gnl\|CDD\|237896	PRK15066, PRK15066, inner membrane transport permease; Provisional.	2.5244e-167
NC_012214.1\|WP_012667188.1\|963973_965254_-\|cystathionine-gamma-synthase-family-protein	gnl\|CDD\|180809	PRK07049, PRK07049, cystathionine gamma-synthase family protein.	0
NC_012214.1\|WP_012667191.1\|967034_967961_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.15672e-102
NC_012214.1\|WP_012667176.1\|949181_949529_-\|YacC-family-pilotin-like-protein	gnl\|CDD\|370620	pfam09691, T2SS_PulS_OutS, Type II secretion system pilotin lipoprotein (PulS_OutS). This family comprises lipoproteins from four gamma proteobacterial species: PulS protein of Klebsiella pneumoniae (P20440), the OutS protein of Erwinia chrysanthemi (Q01567) and Pectobacterium chrysanthemi, and the functionally uncharacterized E. coli protein EtpO. PulS and OutS have been shown to interact with and facilitate insertion of secretins into the outer membrane, suggesting a chaperone-like, or piloting function for members of this family. In the pilotin from this four-helix protein from enterohemorrhagic Escherichia coli, the straight helix alpha2, the curved helix alpha3 and the bent helix alpha4 surround the central N-terminal helix alpha1. These helices create a prominent groove, mainly formed by side chains of helices 1,2 and 3 suggesting this groove is important as a binding site.	3.19667e-09
NC_012214.1\|WP_012667185.1\|960233_961238_+\|type-I-F-CRISPR-associated-protein-Csy3	gnl\|CDD\|378222	pfam09615, Cas_Csy3, CRISPR-associated protein (Cas_Csy3). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2463 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy3, for CRISPR/Cas Subtype Ypest protein 3.	0
NC_012214.1\|WP_012667186.1\|961246_961801_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	gnl\|CDD\|378224	pfam09618, Cas_Csy4, CRISPR-associated protein (Cas_Csy4). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family, typified by YPO2462 of Yersinia pestis, is a CRISPR-associated (Cas) family strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy4, for CRISPR/Cas Subtype Ypest protein 4.	8.98612e-80
NC_012214.1\|WP_012667189.1\|965507_966044_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|185321	PRK15423, PRK15423, hypoxanthine phosphoribosyltransferase; Provisional.	1.37704e-108

>NC_012214.1|WP_012667186.1|961246_961801_+|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4
MDHYQDIRVRVDEENGEAVLLAQVFMHLHQVLMRAANGRIGISFPNVKRTLGDRIRLHGTLDDLSALQQSGWNKCLRDYIACSDIAPVPKGAAWRTVRRVQVKSSAERLRRRSVNKGWLSEQEAAERISVLNEQRSNLPFLQIKSGSNGQAWRLFIEHGSLVSAPSDGSFSSYGLSAAATIPWF
>NC_012214.1|WP_012667185.1|960233_961238_+|type-I-F-CRISPR-associated-protein-Csy3
MAKSAIKTASVLAFERKLSNSDAIMLAGKWQDEQNWTPIKIQEKAVRGTISNRLKNAIASDPLKLDAEIQKPNLQRVDVAALPYNCDSLKVCFTLRVLSGLATPAVCNDRAYQAALAAVIDGYIARHGFSTLAARYAENIANGRFLWRNRLGAGRIAVQVTSGEKCWQFDSYDYSLQAFSQPQGDLLELAQAIEQGLSGNSFALFNVEARVYLGNGQEVFPSQELVLDGNSKKSKLLYQIDGTAAIHSQKIGNALRTIDSWYPDADELDEGPISVEPYGSVTSRGIAYRQPIKKMDFYNLLDNWVTKDKEPDTEQQHYVMAILIRGGVFGEKSE
>NC_012214.1|WP_012667184.1|959265_960210_+|type-I-F-CRISPR-associated-protein-Csy2
MSALIVLRHLRVENANAIAGLTWGFPAITHFLGFTHALSRKLQQSHNITLSGCGVICHQQQVHAYTSGQDYWFALTRNPLTKEAKIAAFNEEGRMHMTVSLLVECHGSIVGGEQGAAELMQTLANLCQRFRLAGGTVTSVGQVQISGWPQDDGETRRIMRRLLPGFALLDRSALLAAHHSQPPQAEMLDTWLDFAALKMQADDGATPADGNVQWQYQPKPGTGYLVPLMTGYRAISPLCPPGEVANSRDNETPFRFTEAVYGVGEWRGLHRIDDLRHLLWRYHHQDEYYLCRSEETACDQDYPDDDEDDDINYN
>NC_012214.1|WP_012667183.1|957919_959269_+|type-I-F-CRISPR-associated-protein-Csy1
MLRETLASFITSYIAARKTAKLEAFDKESAKKLAALASEDQISVLRQQLQQQRAELEQKYQPQAWLSDAASRAGQINLVTHAAKFTHSDARGSSIFASSSVQHEMYLSTAALQKPALDVVGNAAILDVAKLLQTEVEGNSLIASLQRGDYSALESLTDNPELCASWVNGFKQVLVDRQPASHKLAKQIYFPIADGQYHLLSPLFSSALAHALNQRIISAKFSEEAKTARAALKAKSWHDGPVVAYPGTAITQFGGTKPQNISYLNSVRGGKVWLLPCAPPVWQTQSQPPSQHKSIFNFSNDFSRQSWPVIQRLKHFLRRVKTLDSTLDIRQQRLAMTDEIIDILFNYVAGLQNQTDLRGWSAHPDCVLKRSQQLWLDPWRSQDDAEFQFEREGGDWKNEVARDFGHWLSRHLHSDKLNMGETERRHFSTAPLFKQRLRELEKDLAEDLS
>NC_012214.1|WP_012667182.1|957164_957461_+|BrnA-antitoxin-family-protein
MPKLKPGTVFPSAEEDAKIYAAVADDEDSMLLEDPQLKLTPLKKRGRPQKAQPKIAVSVRYTPEVISAFKASGAGWQTRMDVALQDWLKTHRPTEIKL
>NC_012214.1|WP_012667181.1|956899_957178_+|BrnT-family-toxin
MDICYDPDKDVKNRRKHGYSLADSALLDWDEMVVYEDNRQPYDEIRLIGLTYGLARLGNRIFSVCFTEHEEVYRIISLRLATRKEIQRYAET
>NC_012214.1|WP_012667180.1|953514_956826_+|type-I-F-CRISPR-associated-helicase-Cas3
MNILLIAQCNKRALEDSRRILDQFAERKGDRSWQTAITQQGLLTLRKLLRKTARRNTAVACHWIKSNGQSELLWIVGNLRRFNAQGAVPTHTTSRDVLKSADENSWHSVEAVSLLAAIAGLFHDFGKANSLFQQMLVGKKGVKSFQPYRHEWVSLRLFCAWVAGRDDRAWIAALSDIGPQDEQAMLAGLQKDGLMPTKNPFDPLPPVARVVAWLILSHHRMPVYPKKDDLPPQMTWLPPELEHCDGWLTRELDALWNALNHHHDWKPAELQAQWQFPQGTPMQSGRWCGKARKMAQRLLAQPAWLAQIDINQRFSCHMARLALMLADHVYSRQAATPGWQDADCLPYANTDNGRPKQRLDEHNIGVAQNALLLARSLPHLRKTLPAIARHKGFKKRSENSTFRWQDNAWQATCNLRDRAFQQGFFGINMASTGCGKTFANARIMYALSDEQKGCRFAVALGLRTLTLQTGDALREKLKLEQDDLAVLVGSQAVTQLHQQAKDSPTPPVPGSESAAPLPEENQYVSYEGSLDDGRLSRWLKDSPRINKLLSAPVLVTTIDHLIGATEGLRGGKQIAPMLRLLTSDLVLDEPDDFDIEDQHALCRLVNWAGMLGSRVLLSSATLPPALVLALYNAYRSGREVFQHACGLPVDGNICCAWFDENAVLTEDLRLPQEFMQQHQEFVARRVSWLAKQPVLRRGWIAPVAPPARDDGTIYRHMAQVILQSMMTLHHAHHQRHPVSGKTISTGVIRLANINPLVAVAQQLLATGAAEDTHIHYCVYHSQHPLAMRSHFEQRLDATLTRHQPEAIWQVAEIAEALEQHPQQHHLFVVLATSVAEVGRDHDYDWAIAEPSSMRSLIQLAGRVQRHRQQEAQSENIHMLQQNIRSLKARDSQKPAYCQPGFEHKDYMLASHDLQQILDKEQYQTISAIPRIQQRREAKKRQPFTNLADLEHQRLMVELQGKQDKKDKQVKQDKPLPYCAALWWREQASWCGEMQRHKPFRQSQPEDMHFMLIAEEGDQPEIWQPDDGPSGRKQSMMTYPDLTFAAGISAWIAPDYQQVWQQLADSLTMELEEVSLRFGEIMLRSGRDDEIWHFHPLLGVFKAQ
>NC_012214.1|WP_012667179.1|952540_953518_+|type-I-F-CRISPR-associated-endonuclease-Cas1
MEMIKPSDLKTILHSKRSNIYYLQYCRVLVNGGRVEYVTDEGKQSLYWNIPIANTTVVMLGTGTSVTQAAMREFARAGVLVGFCGGGGTPLYAANEVEVDVSWLNSQSEYRPTEYLQHWVSFWFDEQKRLSAAIAFQHVRISQIRQAWLGSKMMREHKFAISEPQLTGILDRFEQGLARCNNNTDLLALEAVMTKALYKLAAQAVSYGDFIRAKRGGGIDAANRFLDHGNYLAYGLAAVACWVIGLPHGLAVLHGKTRRGGLVFDVADLIKDALILPQAFLAAMAGEEEQEFRQRCLTSLQNAEALDTMIAALEATARQYSQVGK
>NC_012214.1|WP_012667177.1|949707_951303_+|multicopper-oxidase-CueO
MQRRDFIKLSAALGAAGALPVWSRALMAAEQRPLLPIPTLLTPDARSEISLTAQASSSGWRGWGYNANLPGPALQLERGKEVNITVYNRLPEATTVHWHGLEVPGDIDGGPQARIEPNHSRRVTFTPDQPAATCWFHPHQHGRTGFQVAQGLAGLVLIADPESGKLLLPKQWGIDDIPVVLQDKRLSADGSRIDYQLDIISAAVGWFGDTMLTNGAIYPQHGVPRGWLRLRLLNGCNARSLNLTTSDKRPMYVIASDGGLLGEPVQVSELPMMPGERYEVLVNTTDGKAFDLQTLPVRQMGMTLEPFNQPLPVLSLVPLLVQASGTLPDKLASLPAMPSSQGLNTRWLQLMMDPELDRRGMQALMDKYGHAAMAGISMDAHGGGKKAGANNHDMSSMDHGKMATMNHGSSAQQQEYDFHNGNQINGMAFNRDKPSFEVKRGVYEKWTISGEGDEMLHPFHIHGTQFRILSENGKPPAAHRSGWKDTVRVEGWRSEVLVRFNHPADRAHAYMAHCHLLEHEDTGMMLGFTVA
>NC_012214.1|WP_012667176.1|949181_949529_-|YacC-family-pilotin-like-protein
MKKSIKALLLSGLFGFTSTSFALSEPEAEDLADLTAVFVYLKNDCGYRDLPDAQIRRALVFFAQQNRWDLTNYSSFNMKALGEDSYRDLSGIAVPNDTKCKSLARDSLNLLAWVK
>NC_012214.1|WP_012667187.1|962981_963659_+|helix-turn-helix-transcriptional-regulator
MNIYTQKLSSRKKVVLVTDDRYFYLGIKSASMSNLAITALGFDRFMDESVSADALVVVDMLSWAFFKPSNETSFYEKMIKNKKPEDVVMLTSNIFQEVITDMLYPGLCKVDRKLSLSFFSELSANKIRRNSARWCPAFAKKRGLTNREMNIILELFRGGKEDEISMQLNICQKTVSAHKLSALSKVGCKNISHFFLLGRPFYRDLKFLLSPRRNSLSGEGFSVSQ
>NC_012214.1|WP_012667188.1|963973_965254_-|cystathionine-gamma-synthase-family-protein
MSSSHSKKTHIGQRELQPETQMLNYGYDPALSEGAVKPPVFLTSTFVFNSAEEGRDFFDYVSGRREPPAGEGNGLVYSRFNHPNSEIVEDRLAIYERSESAALFSSGMSAIATTLLTFVRPGDAILHSQPLYGGSETLLGKTFGNLGVAAVGFADGIDEASVQAAADKALAKGRVSAILIESPANPTNSLVDIALMKRVADRIERQQQHRPVIACDNTLLGPLFSRPLEHGADISLYSLTKYVGGHSDLIAGAAMGNQALIRQVKALRSAIGTQLDPHSSWMIGRSLETLALRMERAGDNAAAVAEFLRSHPQVEQIHYLPFLCPDSAAGKIYSAQCSGAGSTFSFDICGGQDAAFRFLNGLQLFKLAVSLGGTESLASHPASTTHSGVDAAVRERIGIKASTIRLSIGIENKDDLIEDLRLALNK
>NC_012214.1|WP_012667189.1|965507_966044_+|hypoxanthine-phosphoribosyltransferase
MKHTVEVMISEAEIASRITELGKQISEHYRNSGSDMVLVGLLRGSFMFMADLCRAIDVSHEVDFMTASSYGNGTTSNRDVKILKDLDEDIRDKDVLIVEDIIDSGNTLSKVREILSLRGPKSMAICTLLDKPSRREVAVPVEYVGFAIPDEFVVGYGIDYAQRYRHLPYVGKVVLLDE
>NC_012214.1|WP_041474092.1|966143_966806_-|carbonate-dehydratase
MKDINTLIRNNRRWSRLLKEEDPGFFERLSLAQKPRFLWIGCSDSRVPAERLTGLEPGELFVHRNVANLVVHTDLNCLSVVQYAVEVLEVEHIIICGHYGCGGVQAALENPELGLIDNWLLHIRDLWYKHSALLGELPPEKRVDKLCEINVIEQVYNLGHSTIMQSAWKRGQNVNIHGWVYGIQDGYLRDLEVTATNREILEQRYRQGIANLLNDPDLNP
>NC_012214.1|WP_012667191.1|967034_967961_+|ABC-transporter-ATP-binding-protein
MTYALELEKLTKTYQGGVQALRGIDLAVEAGDFYALLGPNGAGKSTTIGIISSLVNKTAGKVRVFGYDLQKDVVNAKRQLGLVPQEFNFNQFETVLQIVVSQAGLYGVEKTVALKRAEKYLTQLDLWGKRNERARMLSGGMKRRLMIARALMHEPKLLILDEPTAGVDIELRRSMWTFLQQLNAQGTTIIMTTHYLEEAEMLCRNIGIIQHGELVENTSMKALLAKQKSETFILDLAAKSPLPQLEGFQYRLTDTSTLEVEVLREQGLNSVFSQLSHQGVQVLSMRNKANRLEELFVDLVNGRSGDKA
>NC_012214.1|WP_012667192.1|967957_968728_+|ABC-transporter-permease
MTHLYWVALKSIWGKEVDRFARIWIQTLVPPVITMTLYFIIFGNLIGSRIGEMHGFSYMQFIVPGLIMMAVITNAYANVVSSFFSAKFQRNIEELLVAPVPTHVIIAGYVGGGVARGICVGVLVTAISLFFVPFHVHSWLMVAVTLLLTAILFSLAGLLNAVFARTFDDISLIPTFVLTPLTYLGGVFYSLTLLPPVWQMVSKLNPIVYMISGFRYGFLGINDVPLAFTLGVLVVFILVFYVLVWFLIQRGSGLRT
>NC_012214.1|WP_012667193.1|968796_969177_-|aspartate-1-decarboxylase
MNRTMLQGKLHRVKVTQADLNYEGSCAIDQDFLDACGILQYEAIDIYNVNNGQRFSTYAIAAERGSKIISVNGAAARCACVGDLLIICSYVQMPDEQAREWQPEVAYFEGDNQMKRVAKAVPVQVA
>NC_012214.1|WP_012667194.1|969240_970095_-|pantoate--beta-alanine-ligase
MLIIETLPMLRREVRRWRQDGKRIALVPTMGNLHDGHMTLVDEARERADIVIVSIFVNPMQFERAEDLAHYPRTLQEDCEQLNRRGVDLVFSPAPADIYPHGLDGQTFVDVPGLSTLLEGASRPGHFRGVSTLVSKLFNLVQPDLACFGEKDYQQLALIRKMVADMDYDIEIVGVPTVRAKDGLALSSRNGYLTADERKIAPGLSNVMQQIAERLGQGERHIEEMIANAESALAEKGLRADGLAIVDADTLLPLNVDSQRAVILMAAWLGKARLIDNQQVDLTQ
>NC_012214.1|WP_012667195.1|970110_970905_-|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MKPTTVSTLRQWKQQGHKFATLTAYDFSFARLFADEGIQVLLVGDSLGMVVQGQQSTLPVTVADIVYHTQAVRRGAPAALLLADLPFMSYATPEQTFDSAAQLMRAGANMVKLEGGKWLAETVEQLTERAVPVCGHLGLTPQSVNIFGGYKVQGRDAEAADRLLEDALALEAAGMQLLVLECVPVALAKRVTEALAVPVIGIGAGNATDGQILVMHDAFGITGGHIPKFAKNFLAETGDIRAAVRQYVAEVEAGRYPAEQHSFQ
>NC_012214.1|WP_012667196.1|970983_971463_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MTRVYLALGSNLADPLHQVQSALDALAAIPDCQLVATSSLYRTPPYGPPDQPDFLNAAVALDTRLDAETLLDHTQRIEREQGRVRKAHRWGPRTLDLDMMLFGDRTLNTPRLTVPHYDMHNRAFMLVPLLEIAPALCLPNGRQLANILATLDSSAIRPW

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Crispr_ID: NC_012214_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012214_7

2539000-2539102

Orphan

Consensus_repeat	Method
CGCAGCTTCAACCGCTGGCGGCTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012214_7

>merge|NC_012214|7|2539000-2539102|CRISPRCasFinder
CGCAGCTTCAACCGCTGGCGGCTGTTGCCATGCCGTAGCCGCAGCTTCAGCCGCTGGCGGCTGTTGCCATGCCGTAGCCGCAGCTTCAGCCGCTGGCGGCTGT

>NC_012214|7|7|2539000-2539102|CRISPRCasFinder
CGCAGCTTCAACCGCTGGCGGCTGT	TGCCATGCCGTAGCCGCAGCTTCAGCCGCTGGCGGCTGTTGCCATGCCGTAGC
CGCAGCTTCAGCCGCTGGCGGCTGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_012214.1\|WP_012668561.1\|2530939_2532091_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|179614
NC_012214.1\|WP_012668566.1\|2536569_2537181_-\|outer-membrane-lipoprotein-chaperone-LolA	unknown	unknown	gnl\|CDD\|129638
NC_012214.1\|WP_012668570.1\|2544790_2546521_+\|cysteine/glutathione-ABC-transporter-ATP-binding-protein/permease-CydC	unknown	unknown	gnl\|CDD\|236865
NC_012214.1\|WP_012668559.1\|2526877_2527963_-\|3-phosphoserine/phosphohydroxythreonine-transaminase	unknown	unknown	gnl\|CDD\|235428
NC_012214.1\|WP_014543870.1\|2551184_2551412_+\|cold-shock-like-protein-CspD	unknown	unknown	gnl\|CDD\|184960
NC_012214.1\|WP_012668563.1\|2533183_2533477_+\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_012668575.1\|2551593_2553246_-\|ATP-dependent-endonuclease	unknown	unknown	gnl\|CDD\|226121
NC_012214.1\|WP_014539130.1\|2533537_2533720_+\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_002211347.1\|2547601_2547820_+\|translation-initiation-factor-IF-1	unknown	unknown	gnl\|CDD\|178954
NC_012214.1\|WP_012668565.1\|2535218_2536562_-\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NC_012214.1\|WP_012668572.1\|2548144_2550421_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA	unknown	unknown	gnl\|CDD\|236828
NC_012214.1\|WP_012668571.1\|2546551_2547244_+\|leucyl/phenylalanyl-tRNA--protein-transferase	unknown	unknown	gnl\|CDD\|234720
NC_012214.1\|WP_012668569.1\|2543024_2544794_+\|cysteine/glutathione-ABC-transporter-permease/ATP-binding-protein-CydD	unknown	unknown	gnl\|CDD\|236870
NC_012214.1\|WP_012668560.1\|2528271_2530029_+\|30S-ribosomal-protein-S12-methylthiotransferase-accessory-protein-YcaO	unknown	unknown	gnl\|CDD\|132588
NC_012214.1\|WP_012668573.1\|2550449_2550770_-\|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl\|CDD\|178809
NC_012214.1\|WP_012668564.1\|2533829_2535122_-\|serine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235461
NC_012214.1\|WP_004156893.1\|2540896_2541391_-\|leucine-responsive-transcriptional-regulator-Lrp	unknown	unknown	gnl\|CDD\|183009
NC_012214.1\|WP_012668562.1\|2532466_2532994_+\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_012668558.1\|2525502_2526789_-\|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|235037
NC_012214.1\|WP_014539135.1\|2541916_2542882_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|182343

Protein	Function_ID	Function_description	E-value
NC_012214.1\|WP_012668561.1\|2530939_2532091_-\|MFS-transporter	gnl\|CDD\|179614	PRK03633, PRK03633, putative MFS family transporter protein; Provisional.	0
NC_012214.1\|WP_012668571.1\|2546551_2547244_+\|leucyl/phenylalanyl-tRNA--protein-transferase	gnl\|CDD\|234720	PRK00301, aat, leucyl/phenylalanyl-tRNA--protein transferase; Reviewed.	1.33529e-139
NC_012214.1\|WP_012668570.1\|2544790_2546521_+\|cysteine/glutathione-ABC-transporter-ATP-binding-protein/permease-CydC	gnl\|CDD\|236865	PRK11160, PRK11160, cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed.	0
NC_012214.1\|WP_012668559.1\|2526877_2527963_-\|3-phosphoserine/phosphohydroxythreonine-transaminase	gnl\|CDD\|235428	PRK05355, PRK05355, 3-phosphoserine/phosphohydroxythreonine transaminase.	0
NC_012214.1\|WP_014543870.1\|2551184_2551412_+\|cold-shock-like-protein-CspD	gnl\|CDD\|184960	PRK14998, PRK14998, cold shock-like protein CspD; Provisional.	8.22847e-43
NC_012214.1\|WP_012668575.1\|2551593_2553246_-\|ATP-dependent-endonuclease	gnl\|CDD\|226121	COG3593, COG3593, Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair].	2.78333e-158
NC_012214.1\|WP_002211347.1\|2547601_2547820_+\|translation-initiation-factor-IF-1	gnl\|CDD\|178954	PRK00276, infA, translation initiation factor IF-1; Validated.	2.9822e-48
NC_012214.1\|WP_012668565.1\|2535218_2536562_-\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NC_012214.1\|WP_012668572.1\|2548144_2550421_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA	gnl\|CDD\|236828	PRK11034, clpA, ATP-dependent Clp protease ATP-binding subunit; Provisional.	0
NC_012214.1\|WP_012668573.1\|2550449_2550770_-\|ATP-dependent-Clp-protease-adapter-ClpS	gnl\|CDD\|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	1.62636e-50
NC_012214.1\|WP_012668569.1\|2543024_2544794_+\|cysteine/glutathione-ABC-transporter-permease/ATP-binding-protein-CydD	gnl\|CDD\|236870	PRK11174, PRK11174, cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed.	0
NC_012214.1\|WP_012668560.1\|2528271_2530029_+\|30S-ribosomal-protein-S12-methylthiotransferase-accessory-protein-YcaO	gnl\|CDD\|132588	TIGR03549, TIGR03549, YcaO domain protein. This family consists of remarkably well-conserved proteins from gamma and beta Proteobacteria, heavily skewed towards organisms of marine environments. Its gene neighborhood is not conserved. This family has an OsmC-like N-terminal domain. It shares a YcaO domain, frequently associated with ATP-dependent cyclodehydration for peptide modification. The function is unknown. Fifteen of the first sixteen members of this family are from selenouridine-positive genomes, but this correlation may not be meaningful.	0
NC_012214.1\|WP_012668564.1\|2533829_2535122_-\|serine--tRNA-ligase	gnl\|CDD\|235461	PRK05431, PRK05431, seryl-tRNA synthetase; Provisional.	0
NC_012214.1\|WP_004156893.1\|2540896_2541391_-\|leucine-responsive-transcriptional-regulator-Lrp	gnl\|CDD\|183009	PRK11169, PRK11169, leucine-responsive transcriptional regulator Lrp.	3.09907e-115
NC_012214.1\|WP_012668566.1\|2536569_2537181_-\|outer-membrane-lipoprotein-chaperone-LolA	gnl\|CDD\|129638	TIGR00547, Outer-membrane_lipoprotein_carrier_protein, periplasmic chaperone LolA. This protein, LolA, is known so far only in the gamma and beta subdivisions of the Proteobacteria. The E. coli major outer lipoprotein (Lpp) of E. coli is released from the inner membrane as a complex with this chaperone in an energy-requiring process, and is then delivered to LolB for insertion into the outer membrane. LolA is involved in the delivery of lipoproteins generally, rather than just Lpp, and is an essential protein in E. coli, unlike Lpp itself. [Protein fate, Protein and peptide secretion and trafficking].	1.76847e-100
NC_012214.1\|WP_012668558.1\|2525502_2526789_-\|3-phosphoshikimate-1-carboxyvinyltransferase	gnl\|CDD\|235037	PRK02427, PRK02427, 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional.	0
NC_012214.1\|WP_014539135.1\|2541916_2542882_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|182343	PRK10262, PRK10262, thioredoxin reductase; Provisional.	0

>NC_012214.1|WP_012668566.1|2536569_2537181_-|outer-membrane-lipoprotein-chaperone-LolA
MKKLIISCCLLATFTAAGAWADATSDLQQRLDKVKSFHATFDQKVTDGSGASVQDGEGEMWVQRPNLFNWHMTAPDESILIADGKTLWFYNPFVEQVSASLLKDATSNTPFMLIARNQASDWKQYHVTQKGDDFSLTPKSADGNLKQFTINVAQNGTINQFSAIEQDGQRSSYALKSQKNGPISADKFKFTPPKGVTVDDQRQ
>NC_012214.1|WP_012668565.1|2535218_2536562_-|replication-associated-recombination-protein-A
MSNLSLDFSRNEFQPLAARMRPRTLAEYIGQQHLLAAGKPLPRAIEARHLHSMILWGPPGTGKTTLAEIIGRYGQADVERISAVTSGVKEIREAIERARQNRHAGRRTILFVDEVHRFNKSQQDAFLPHIEDGTITFVGATTENPSFELNSALLSRARVYLLKSLTSEDIATVLDQAMQDGERGYGNDNIVLPENTRNMIAQLVNGDARRALNTLEMMADMAEVNGKGKRELTPQLLNEVSGERSARFDNKGDRFYDLISALHKSVRGSAPDAALYWYARIITAGGDPLYVARRLLAIASEDVGNADPRGMQVAISAWDCFTRVGPAEGERAIAQAIVYLACAPKSNAVYNAFKAALRDARESPDYDVPEHLRNAPTKLMKEMGLGAEYRYAHDEANAYAAGENYFPPELAQTRYYQPTSRGLEGKIGEKLAWLTEQDQNSPIKRYR
>NC_012214.1|WP_012668564.1|2533829_2535122_-|serine--tRNA-ligase
MLDPNLLRNEPDAVAEKLARRGYKLDVDTLRAHEERRKVLQVETENLQAERNSRSKSIGQAKARGEDIEPLRQEVNALGERLDAAKAELDALLTSINDFSMAIPNIPADVVPLGKDDSENQEIGRWGVPRKFDFTVRDHVELGERAAGLDFAAAVKLTGSRFIVMKGQIALMHRALSQFMLDLHTEQHGYQETYVPYLVNHASLYGTGQLPKFGEDLFHTRPLDEEASSSNYALIPTSEVPLTNLVRDEILEEESLPLKMTAHTPCFRSEAGAYGRDTRGLIRMHQFDKVEMVHVTRPEDSMDALEELVGHAEKVLQLLNLPYRKVLLCTGDMGFGAQKTYDLEVWLPAQDTYREISSCSNMGDFQARRMKARCRPKGETKTRLVHTLNGSGLAVGRTLVAVLENYQQADGRIEVPEVLRPYMKGLTFIG
>NC_012214.1|WP_014539130.1|2533537_2533720_+|hypothetical-protein
MIDFAGVKPEYSFLNLARLAKKHSINTPGVKITLAQLYKIHSPTIFISRDLVRLLMQRGQ
>NC_012214.1|WP_012668563.1|2533183_2533477_+|hypothetical-protein
MSIALTLIMICLYLITSSVIFHSRRTGEIIAFALVLLVFGWLNHFSTYTLFYTLATVIVNIIIITPLKNREHLTKLKGTAFLLPLATLFNLAEHFIS
>NC_012214.1|WP_012668562.1|2532466_2532994_+|hypothetical-protein
MHVATRELALSATLNGQRVNTQYASENNTSSNKNEYRFNGAGVGASYQLYRLSDFTLIFGGVNAKNGLINRYVLGAVLNWIYDPLLLNVSIGYLDGISKDKFSNDHTAYTTSGKVIFAVNPEINLSQGFSKDFIIAKSRFLNKKERTSTTSMLAGMNINLVENSGHRQCLCISAQ
>NC_012214.1|WP_012668561.1|2530939_2532091_-|MFS-transporter
MFTWSRPVLVLLCGLLLLTVSIAVLNTLVPLWLTHDALPTWQVGIVSSSYYCGNLLGTLIAGWVIKRYGFNRSYYFASLLFALAIVALGLGTGFGLWALWRFIAGIGCALIWVVVESALMCNGTLHNRGRMLAAYMIVYYLGTVIGQLLVSKVSTELMHVLPWVSGVVLAAILPLVFCRVTASRGEEELPAGRMWLMLRRRSARLGINGCIISGILLGSLYGLMPLYLSHQGMSDATVGYWMALLVSAGIIGQWPVGRLADRFGRLLVLRVQVFVVILGALAMLSHAAMAPALFILGCAGFTLYPVAMSWACETVANHELVAMNQALLLSYTVGSLVGPAMTSILMQNYSDRLLFVMIAGVALVYLVMLLRKTDRHATPIAHA
>NC_012214.1|WP_012668560.1|2528271_2530029_+|30S-ribosomal-protein-S12-methylthiotransferase-accessory-protein-YcaO
MTQTFIPGKDAALEVSISRFQQKLQDLGFNIEEASWLNPVPNVWSVHIRDRDCPLCFTNGKGASKKAALASALGEYFERLSTNYFFADFWLGQQVANSDFVHYPDEKWFPLADDDSLPEGILDARLRQFYDPEDEVSASDLVDLQSGNAARGICALPFTRQSDQQTVYIPMNIIGNLYVSNGMSAGNTVNEARVQGLSEVFERHIKNRIIAESLSLPAIPQAVLNRYPGVLEAIATLEAEGFPIFSYDASLGGKYPVICVVLFNPANGTCFASFGAHPDFGVALERTVTELLQGRGLKDLDVFTPPTFDDEEVAEHANLETHFIDSSGLISWDMFKDEADYAFADWSFKGTTEEEFATLMAIFKSEDREVYIADYEHLDVYACRIIVPGMSDIYPAEDLLLANNSMGAYLRDTLLSLPDSSWDKPDYLSLLQQLDDDGHDDFTRVRELLGLATGKDNGWYTLRIGELKAMLALAGGDLQQALIWTEWTMEFNQSIFSAERANYYRCLQTLLLLSQEEGRDPQQYYVAFVRMYGQSAVDAASAAIAGEAPFYGLQSVDDDLKAFPAHQALLAAYEKLQSAKRRHWK
>NC_012214.1|WP_012668559.1|2526877_2527963_-|3-phosphoserine/phosphohydroxythreonine-transaminase
MSQIYNFSSGPAMLPAEVLRRAEQELCNWQGLGISVMEISHRSKEFIQVAEEAEQDFRDLLKIPSNYKVLFCHGGARGQFAAVPQNLLGQNSKADYVDGGYWATSAIKEAQKFCTPNVIDAKTTLNGLRAITPMKSWALSDDAAYVHFCPNETIDGIAIHETPDFGDKVVVADLSSTIMSTPVDVSRYGVLYAGAQKNIGPAGLTLVVVREDLLGQARKELPSILDYKVLAESDSMFNTPPTFAWYLSGLVFKWLKEQGGVSELDKRNQAKADLLYGTIDNSDLYRNDVSAANRSRMNVPFQLADAALDKLFLEESLAAGLHALKGHRVVGGMRASIYNAMPLSGVKTLTDFMVDFERRRG
>NC_012214.1|WP_012668558.1|2525502_2526789_-|3-phosphoshikimate-1-carboxyvinyltransferase
MQDSLTLQPIALVDGTVNLPGSKSVSNRALLLAALAKGTTRLTNLLDSDDVRHMLDALQALGVQHTLSAGRTRCEITGQGGALQAEGALELFLGNAGTVMRPLAAALCIGSNDIILTGEPRMKERPIGHLVDALRQGGADVEYLEQDDYPPLRIKGGFNGGEVTVDGSVSSQFLTALLMAAPLAQNDSQIIIKGDLVSKPYIDITLKLMATFGVVVDNNDYHTFRIRGQQQYQATSEYLVEGDASSASYFLAAAAIRGGTVRVTGIGRNSMQGDIRFADVLEKMGASVEWGDDYIACTRGELRAIDLDMNHIPDAAMTIATTALFAQGTTVMRNIYNWRVKETDRLAAMATELRKVGAEVEEGHDYIRITPPAKIACAQIGTYNDHRMAMCFSLVALSSTPVTILDPKCTAKTFPDYFEQLARISQLA
>NC_012214.1|WP_004156893.1|2540896_2541391_-|leucine-responsive-transcriptional-regulator-Lrp
MVENKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFILGYTAQLNPHYLDASLLVFVEITLNRGAPDVFEQFNAAVQKLEETQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLVIKTR
>NC_012214.1|WP_014539135.1|2541916_2542882_+|thioredoxin-disulfide-reductase
MSTAKHSKLLILGSGPAGYTAAVYAARANLNPVLITGLEKGGQLTTTTDVENWPGDAHELTGPGLMDRMHEHAVKFNTEIVFDHIHSVDLQHRPFRLTGDEGEYTADALIIATGASARYLGLPSEEEFKGRGVSACATCDGFFYRNQKVAVIGGGNTAVEEALYLANIAAEVHLIHRRDSFRAEKILIDRLNEKVKNGNIILHTDYTLYEVLGDQMGVSALRLRSTKDDQTKELAVAGLFVAIGHSPNTAIFNGQLALENGYIKVQSGIHGNATQTSIAGVFAAGDVMDHIYRQAITSAGTGCMAALDAERYLDGLVKNNQ
>NC_012214.1|WP_012668569.1|2543024_2544794_+|cysteine/glutathione-ABC-transporter-permease/ATP-binding-protein-CydD
MNKTRQHILTRWLKSQSVHGQRWLRLSFLSGILSTLLILAQAWLLAALLQALMVDQQPRNALLVHFSLLLACFAGRALLAWLREKAGCQAGQAIRQALRQQVLNRLAHLGPAWIQGKPAGSWATLLMEQIEDMQDYYGRYLPQMMLAGAIPLLVLLVLFPVNWAASLILLATAPLIPLFMAMVGMGAADANRRNFLALSRLSGQFLDRLRGLDTLRLFHRATAETATIATASEQFRQRTMEVLRMAFLSSAVLEFFASISIALIAVYFGFSYLGIFDFGHYSGPVTLFAGFLVLTLAPEFYQPLRDLGTFYHAKAQAVGAADALVSFLDASEAAATERGDLTPQFDKGVNLVATGLTIVSADGQQLAGPLDFTLRPGQRIALVGQSGAGKTSLMNLLLGNLPYRGSLLVNGTELRDIALPHWQQQLAWVGQNPHLPAATLRQNILPGGHLDEVRLQQVLALAGVNEFLPRLPAGLDSDTGDRAATLSVGQAQRVAVARALMKPCRLLLLDEPDASLDAQSEQHVNRALLEASRAQSTLLITHQLDRLAQWDEIWLMHDGKIVQQGCWDTLANQPGPFAGLLAQRGGSLE
>NC_012214.1|WP_012668570.1|2544790_2546521_+|cysteine/glutathione-ABC-transporter-ATP-binding-protein/permease-CydC
MKTLLPFLKLYRRHTLRLLCGILLAATTLLASIGLLTLSGWFLAATSLAGVAGIYSFNYMLPAAGVRGAAISRTVARYLERLVSHDGTFRVLQHLRVFTFSKLLPLSPAGLTRFRQGDLLNRLVADVDTLDHLYLRVIAPLVGALTVMVVVTTGLSWLDGRLALTLGALMLLTLLLLPPIFYRAGLPVGIDLTRLRSEYRNSLTSWLQGQTELSLYGAAGRFRQGMDATEAAWLVAQRRQASLTGMSQGLVMLMGGIAVTLILWLTASGVGGDAHPGAYIALFVFCALAAFEALGPVGTAFQHLGHVIASAQRVSEIMAQRPQVTFAAKGTAPQPDAAALSLNNVSFRYDDGPFAIENLSLDIAAGQHIALLGRTGCGKSTLLQLLTRAWDPQCGSILLNGQPLHAWSETELRACTSVVTQRVHLFSASLRDNLLLAAGSSQDEQLSDALRQVGLEKLLNNDAGLDAWLGEGGRQLSGGELRRLGLARALLHNAPLMLLDEPTEGLDAETEQQILALLRKVASGKTLIMVTHRLHGLAHFDQICVLDNGQLIEQGNHRQLVAKQGRYWTFLQRFAL
>NC_012214.1|WP_012668571.1|2546551_2547244_+|leucyl/phenylalanyl-tRNA--protein-transferase
MRLIQLSRESLNFPPPEKALREPNGLLAMGGDLSPQRLLNAYHRGIFPWFSPGDPILWWSPDPRAILLPQHFHLSRSMKRFHQHSSYRVTLNQRFREVIEGCACDRQEGTWITHEVKHAWQRLHALGHAHSVEVWHGDELVGGMYGLALGQIFCGESMFSRRENASKTALLVFCHYFLQQGGKLIDCQVLNPHTRSLGAQEISRASYLEYVSSLAFQPLSANCWRAQRLF
>NC_012214.1|WP_002211347.1|2547601_2547820_+|translation-initiation-factor-IF-1
MAKEDNIEMQGTVLDTLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVTVELTPYDLSKGRIVFRSR
>NC_012214.1|WP_012668572.1|2548144_2550421_-|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPSAREALEACAVDIVALRQELEAFIEQTTPVLPVSEKDRDTQPTLSFQRVLQRAVFHVQSSGRSEVAGANVLVAIFSEQESQAAYLLRKHEVSRLDVVNFISHGMRKDEPGPASGAENPINEEQAGGEERMENFTTNLNQLARVGGIDPLIGREKELERAVQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPEVMKECTIYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDHNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSGGKIRVMGSTTYQEFSNIFEKDRALARRFQKIDITEPSIDETVQIIIGLKPKYEAHHDVRYTAKAVRAAVELAVKYINDRHLPDKAIDVIDEAGARARLMPVSKRKKTVNVADIETVVARIARIPEKSVSASDRDSLKTLGDRLKMLVFGQDNAIEVLTEAIKMSRAGLGQDRKPVGSFLFAGPTGVGKTEVTVQLAKALGIELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAVVLLDEIEKAHPDVFNLLLQVMDNGMLTDNNGRKADFRNVVLVMTTNAGVRETERKSIGLIQQDNSTDAMEEIKKIFTPEFRNRLDNIIWFKHLDQAVIHQVVDKFIVELQAQLDAKGVSLEVSDDARDWLADKGYDKAMGARPMARTVQENLKKPLANELLFGSLVEGGSVSVTLDKEKNQLTYHFLSAEKRKAEGAVH
>NC_012214.1|WP_012668573.1|2550449_2550770_-|ATP-dependent-Clp-protease-adapter-ClpS
MGKTNDWLNFEQLANDKVREALKPPSMYKVILNNDDFTPMEFVIDVLQKFFSYDIERATQLMLTVHYQGKAVCGVFTAEVAETKVAHVNKYARDNEHPLLCTLEKA
>NC_012214.1|WP_014543870.1|2551184_2551412_+|cold-shock-like-protein-CspD
MMTGTVKWFNNAKGFGFICPVGGGDDIFAHYSTIQMDGYRTLKAGQQVQFDVHQGPKGNHASLIVPVEEVLAISA
>NC_012214.1|WP_012668575.1|2551593_2553246_-|ATP-dependent-endonuclease
MILEKIAVSGFRGINKLSLRLEENNVLIGENAWGKSSLLDALTLLLAPGEPYQFSAGDFHSPPGDNPGRERHIQIRFTFREFEAGQRNAARYAELSDLWQRGEAGTPQLCYQVLGERLADGTVITRHHFLDELGKVLAGDGTGRLRTLKRLHPVLRLRDARFNRRMHLEPTQHGDEAGFNVLVAQIDTLTRDLHSRPQSLTDSALRQGLRTMQQLLEHYFSLQQPSAASQSGRLSHQMASRSGWRYLDNINRLIAEADSRSRRVILLRMFALLLQVRGAHQLDAQARPLLLIEDPETRLHPVMLAVAWGLLNLLPLQKITTTNSGELLSQVPVEQVCRLVREPERVAAWRIGPGGLSAEESRRIAFHIRFNRPSSLFARCWLLVEGETEVWIMNELAHQCGHHFAAEGVKVIEFAQCGLRPLLTFAGRMGIEWHVLTDGDDAGRKYAATAHSLLDGEPEQQHLTQLPALDMEHFLYRQGFSEVYHRIARLPSNVPMNLRRIIAKAVHHSSKPELAIAVAMDAAERGSEAVPALLRKMFARVQWLARGKTE

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Crispr_ID: NC_012214_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012214_8

3764248-3764360

Orphan

Consensus_repeat	Method
TCGCAATTGCTATACGTTTAGACATATTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012214_8

>merge|NC_012214|8|3764248-3764360|CRISPRCasFinder
TCGCAATTGCTATACGTTTAGACATATTATTGCCAGAGGTAGTTTCTTGCGAGACAGAATTCGAACTGCAATCATCCGACATACTCGCAATTGCCATACGTTTAGACATATTA

>NC_012214|8|8|3764248-3764360|CRISPRCasFinder
TCGCAATTGCTATACGTTTAGACATATTA	TTGCCAGAGGTAGTTTCTTGCGAGACAGAATTCGAACTGCAATCATCCGACATAC
TCGCAATTGCCATACGTTTAGACATATTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012214.1\|WP_015899120.1\|3762620_3763025_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_015899123.1\|3764866_3767314_-\|glycogen-phosphorylase	unknown	unknown	gnl\|CDD\|184948
NC_012214.1\|WP_014539725.1\|3760218_3760962_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_014539735.1\|3775989_3777330_-\|gluconate-transporter	unknown	unknown	gnl\|CDD\|182485
NC_012214.1\|WP_015899127.1\|3777326_3777875_-\|gluconokinase	unknown	unknown	gnl\|CDD\|236926
NC_012214.1\|WP_014539731.1\|3768823_3770110_-\|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234824
NC_012214.1\|WP_041474061.1\|3759000_3759309_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_041474060.1\|3757198_3757648_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235175
NC_012214.1\|WP_015899128.1\|3778111_3779107_-\|gluconate-operon-transcriptional-repressor-GntR	unknown	unknown	gnl\|CDD\|184949
NC_012214.1\|WP_041474063.1\|3770122_3772099_-\|glycogen-debranching-protein-GlgX	unknown	unknown	gnl\|CDD\|235152
NC_012214.1\|WP_015899118.1\|3759695_3759944_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_014539738.1\|3779307_3780003_-\|pirin-family-protein	unknown	unknown	gnl\|CDD\|380375
NC_012214.1\|WP_015899125.1\|3772095_3774282_-\|1,4-alpha-glucan-branching-enzyme	unknown	unknown	gnl\|CDD\|235445
NC_012214.1\|WP_014539723.1\|3757748_3758633_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_015899117.1\|3758717_3759008_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_014539730.1\|3767333_3768767_-\|glycogen-synthase-GlgA	unknown	unknown	gnl\|CDD\|234809
NC_012214.1\|WP_014539734.1\|3774694_3775804_-\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|235839
NC_012214.1\|WP_014539720.1\|3755023_3755347_-\|thiosulfate-sulfurtransferase-GlpE	unknown	unknown	gnl\|CDD\|178908
NC_012214.1\|WP_014539726.1\|3761673_3762579_-\|hypothetical-protein	unknown	unknown	unknown
NC_012214.1\|WP_014539721.1\|3755585_3757091_+\|glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|237027

Protein	Function_ID	Function_description	E-value
NC_012214.1\|WP_015899123.1\|3764866_3767314_-\|glycogen-phosphorylase	gnl\|CDD\|184948	PRK14986, PRK14986, glycogen phosphorylase; Provisional.	0
NC_012214.1\|WP_015899127.1\|3777326_3777875_-\|gluconokinase	gnl\|CDD\|236926	PRK11545, gntK, gluconokinase.	3.47432e-121
NC_012214.1\|WP_041474060.1\|3757198_3757648_-\|hypothetical-protein	gnl\|CDD\|235175	PRK03918, PRK03918, DNA double-strand break repair ATPase Rad50.	0.00731185
NC_012214.1\|WP_015899128.1\|3778111_3779107_-\|gluconate-operon-transcriptional-repressor-GntR	gnl\|CDD\|184949	PRK14987, PRK14987, HTH-type transcriptional regulator GntR.	3.10917e-179
NC_012214.1\|WP_041474063.1\|3770122_3772099_-\|glycogen-debranching-protein-GlgX	gnl\|CDD\|235152	PRK03705, PRK03705, glycogen debranching protein GlgX.	0
NC_012214.1\|WP_014539730.1\|3767333_3768767_-\|glycogen-synthase-GlgA	gnl\|CDD\|234809	PRK00654, glgA, glycogen synthase GlgA.	0
NC_012214.1\|WP_015899125.1\|3772095_3774282_-\|1,4-alpha-glucan-branching-enzyme	gnl\|CDD\|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0
NC_012214.1\|WP_014539731.1\|3768823_3770110_-\|glucose-1-phosphate-adenylyltransferase	gnl\|CDD\|234824	PRK00725, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
NC_012214.1\|WP_014539735.1\|3775989_3777330_-\|gluconate-transporter	gnl\|CDD\|182485	PRK10472, PRK10472, low affinity gluconate transporter; Provisional.	0
NC_012214.1\|WP_014539738.1\|3779307_3780003_-\|pirin-family-protein	gnl\|CDD\|380375	cd02910, cupin_Yhhw_N, Escherichia coli YhhW and YhaK and related proteins, pirin-like bicupin, N-terminal cupin domain. This family includes the N-terminal cupin domains of YhhW and YhaK, Escherichia coli pirin-like proteins with unknown function. YhhW is structurally similar not only to human pirin but also to quercitin 2,3-dioxygenase (quercitinase). Although the function of YhhW is not completely understood, YhhW and its human ortholog have quercitinase activity and are likely to play an important role in transcription and apoptosis. This N-terminal cupin domain of YhhW has a metal coordination site and is thought to have catalytic activity while the C-terminal cupin-like domain has diverged considerably and has closer alignment with C-terminal pirin. YhaK is found in low abundance in the cytosol of E. coli and is strongly up-regulated by nitroso-glutathione (GSNO). There are major structural differences at the N-terminus of YhaK compared with YhhW; YhaK lacks the canonical cupin metal-binding residues of pirins and may be involved in chloride binding and/or sensing of oxidative stress in enterobacteria. YhaK showed no quercetinase and peroxidase activity; however, reduced YhaK was very sensitive to reactive oxygen species (ROS). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	1.17203e-77
NC_012214.1\|WP_014539734.1\|3774694_3775804_-\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|235839	PRK06598, PRK06598, aspartate-semialdehyde dehydrogenase; Reviewed.	0
NC_012214.1\|WP_014539720.1\|3755023_3755347_-\|thiosulfate-sulfurtransferase-GlpE	gnl\|CDD\|178908	PRK00162, glpE, thiosulfate sulfurtransferase GlpE.	2.68435e-58
NC_012214.1\|WP_014539721.1\|3755585_3757091_+\|glycerol-3-phosphate-dehydrogenase	gnl\|CDD\|237027	PRK12266, glpD, glycerol-3-phosphate dehydrogenase; Reviewed.	0

>NC_012214.1|WP_015899120.1|3762620_3763025_-|hypothetical-protein
MTITILDRAGLYVYNKAGWNISSHDAREILYQLKKVEGNPKEMVRNRAAFEALHNKIHGTKIKKSYKEIADFLKKVNYTCENIGLKRCKKYEDSKVIVDNTNLHAVSKENTSDHNMSERMAIANEIYCINKKIL
>NC_012214.1|WP_014539726.1|3761673_3762579_-|hypothetical-protein
MKWQSEQIKFTISSREKPKKIDVLKNIINGHCTKPVTEKERCEIIMKAAEYYQKLHTKLVSKETTELINRYNQLKSDEKNKEIPMIPNEKGNDLLTEKTVTDNEFRCQEIAQKIFAINEGSLMNRMIETACYDEGIPLNSSPDFIAMRNKEVSGINQVVDSINADQKLRDNSHEDTELALADQVIDLQTATKGIPKLTSDIDEFLAEIQARTEIIMAEAEYYLTNMPHNLDEVSKSLIYEYKYLKVVEAKKTDSQRSENKTDEDSTCTPPLTQASGTSETSGTPEISYSPEQRELTGIKKS
>NC_012214.1|WP_014539725.1|3760218_3760962_-|hypothetical-protein
MSITGLDSAVLYIYNKVYKITGKTISDYDARKILYQLRKVENNPVKMAKNKTSCKALHYKMCGTKNDKLHGKIKDFLIRGGYLPKETNFISYIEHKESEVIVDNTHLPAVSEKTTTDHNMSERMAIAKNIYYINKKNFIGERVRVQLVSEGRRLKWQSGPDLTALSSHEKPKKTNFLKKKNKDNFTQLVDEKKRSEVIMEVVKHYQELFPELISKETRDLIDKYNKLKPDEAKKTDSQRSENKTDEI
>NC_012214.1|WP_015899118.1|3759695_3759944_-|hypothetical-protein
MEDKRDLEKLLEKSKEKRAGLARLINEHFTDKSPRARLITLQNEYNQNLVKELKEELAKLNESNENLPKSAEGDAFPSTLST
>NC_012214.1|WP_041474061.1|3759000_3759309_-|hypothetical-protein
MKITILDRVSLYLYNKAGRTISSDKANKILDQIQEVVNNPKKMERMMNNKTIRQALLNKRSKTNSVELKNKISELITIKNHEHKVISLLQRIYAEETISYRG
>NC_012214.1|WP_015899117.1|3758717_3759008_-|hypothetical-protein
MGNTKVNAISKEITYDDNKSECIKIANEIYSINKENVIGRKIRGKPESKNEYADDIWGDCAGSAIGLYSRLKAPGAFLTVLAGIRFLRVPNVHLME
>NC_012214.1|WP_014539723.1|3757748_3758633_-|hypothetical-protein
MSITYSRLLLFKAYDILGVRLSGGDAKRIIQELKSVENTPAGLKLMTNKNLIRALVNKAIDTGNNELRKDICKSLDENTILDKCSIDAIKIIICAENKKNPIISNKKESKRRMEMTSKTTCAENEEIPIISNNKNSDLLKETINDNKLICQEIARNIFSLHEGSLMNLGIETFCNENKIPLNSKSSPDLMAMRNKAVSDIYQVVDNINAYQKLRDNVPKTTELVPADQVIYLQKVTKGSCKLIFEIDKILAERQANTEIIMGSFEYYLTKIPDKLHKESKSLIYKYGNLKAVET
>NC_012214.1|WP_041474060.1|3757198_3757648_-|hypothetical-protein
MKIAYQDPIHTPPLTSASGTSDTSDTPVISFSQVQRRLNDINNNNNPFQPNTRQTVSSPSDAVQQPSTPGAEAKQRIEKELEKTEEKIAVLARLIKATYSDESERDRLTKFNNEYNENLVKELKEELAKLNESNEKLPKSAEGDAFPSR
>NC_012214.1|WP_014539721.1|3755585_3757091_+|glycerol-3-phosphate-dehydrogenase
METKDLIVIGGGINGAGIAADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVGEALAEREVLLKMAPHIAFPMRFLLPHRPHLRPAWMIRMGLFMYDHLGKRTSLPGSKSVLFGSDSILKPEIVRGFEYSDCWVDDARLVVLNAQEVEKRGGTVRTRTRVTRARRENGLWIVEAEDIDSGKIFTWRAKGLVNAAGPWVKQLFDDGLKLKSPYGIRLIKGSHIVVPRIGSQKQAYILQNEDNRIVFVIPWMDEFSIIGTTDVEYKGDAHNVKIDDNEIDYLLKVFNAHFKQDLSRDDIVWSYSGVRPLCDDESDSPQAITRDYTLDVHDDGGQAPLLSVFGGKLTTYRKLAEHAMEKLSKYYPHAGAAWTKSCVLPGGNFAGTREEYAVSLRRRFPFISVELARHYARTYGSNSEQLLKGATSLADLGELFGHHFYEAELRYLVENEWVRATDDAIWRRTKEGMWLNEAQQSRIGEWLAQHAKPLLSLAS
>NC_012214.1|WP_014539720.1|3755023_3755347_-|thiosulfate-sulfurtransferase-GlpE
MDQFECINIRQAQQKLAGGNALLVDIRDAQSFAAAHASGAFHLSNESLPLFIAQSDLSLPVLVMCYHGNSSKGAAQYLLGQGFSAAYSIDGGFEAWRTAFPQQVSAQ
>NC_012214.1|WP_015899123.1|3764866_3767314_-|glycogen-phosphorylase
MNAPFSYAAPTLSVDALKHSIAYKLMFTLGKDPALANKHEWLNATLLAVRDRMVERWLRSNRAQLSQDVRQVYYLSMEFLVGRTLSNALLAMGIYDDTRAALEDMGFDLEELIEEESDPGLGNGGLGRLAACFLDSLATLGLPGRGYGIRYEYGMFKQNIVEGRQAESPDYWLEYGNPWEFQRFNTRYKVRFGGRIQHEGSRARWVETEEVLATAYDQIIPGYDTDTTNTLRLWGAQASNEINLGKFNQGDYFAAVEDKNHSENVSRVLYPDDSTYSGRELRLRQEYFLVSATVQDILHRHWVMHQTFDNLADKIALHLNDTHPVLAIPELMCVLIDEHKFSWDDAFEVVCQVFSYTNHTLMQEALETWPVDMIGKILPRHLQIIFDINDYFLKTIQEQYPDDWELLARISIIDENNGRRIRMAWLAVVASHMVNGVSELHSNLMVQSLFADFAKLFPGRFCNKTNGITPRRWLALANPPLSAVLDKTIGRTWRTELSQLDELKQHIDFPNFIEQIAHAKLQNKKRLAEFVSQKLDIVIDPQAMFDVQIKRIHEYKRQLLNVLHIITRYNRIKADPDADWVPRVSIFAGKAASAYQMAKHIIHLINDVAQVINNDPQVKSKLKVVFIPNYSVSLAQMIIPAADLSEQISLAGTEASGTSNMKFALNGALTVGTLDGANVEMLDHVGAENIFIFGNTTPQVEELRSNGYNSRLCYEQDAELHQVLTQIATGLFSPQEPGRYRNIFDSLVNLGDHYQLLADYRSYVDTQDKVDKLYRNQEAWTRCALHNIANMGYFSSDRTIKEYADDIWGIVPVQL
>NC_012214.1|WP_014539730.1|3767333_3768767_-|glycogen-synthase-GlgA
MQVLHVCSELFPLLKTGGLADVVGALPAAQIAAGDDTRVLLPAFPDLKKGITQTQVVAKLQTFAGYVELHFGHFNGVGIYLIDAPGLFDRPGSPYHDESQYAYSDNYLRFALLGWMSCELACGLDHWWRPDVVHAHDWHAGLACAYLAARGRPAKSVFTVHNLAYQGLFNARHMEQIQLPNAFFSVFGLEFHGQISYLKAGLFYADHVTAVSPTYAREITQPEFGYGMEGLLKQRMLEGRLSGILNGVDPAIWNPAHDLLLSARYNRDVLDAKLENKRQLQIAMGLKIDEKAPIFAVVSRLTKQKGLDLVLEALPGLLEQGGQLVVLGAGDAELQQGFLATAAENPGQVGVQIGYHEAFSHRIMGGADVILVPSRFEPCGLTQLYALKYGTLPLVRRTGGLADTVNDCSLENLADGIASGFSFEDSNAWSLLRAIRRSFVLWSRPSLWRYVQRQAMGMDFSWQVAAVAYRDLYQRLF
>NC_012214.1|WP_014539731.1|3768823_3770110_-|glucose-1-phosphate-adenylyltransferase
MVKLEKHDPVMLARQLPTHTVALILAGGRGTRLKDLTAKRAKPAVHFGGKYRIIDFALSNCLNSGIRRIAVCTQYQSHTLVQHIQRGWSFLNEEMNEFVDLLPAQQRLATDHWYRGTADAVTQNLDIIRRYRAKYIVILAGDHIYKMDYARMLIDHVEHGARCTIACLPVPLEEASAFGVMKVDDDNRVVEFLEKPDNPPSMPGDASRALASMGVYVFDAEYLFDLLEHDQQLPQSTHDFGQDLLPKIVASGEALAHSFSLSCVHQDETAEPYWRDVGTLEAYWKANLDLASVTPELDMYDADWPIHTHMEPLPPAKFVQDRSGSHGMTMNSLVSGGCIISGSVVVNSVLFSRVRINSFCNIESSVLLPDVVVGRSCRLRRCVIDRACVLPEGTVIGENPDDDARRFHRSEEGIVLVTTTMLAKLGWR
>NC_012214.1|WP_041474063.1|3770122_3772099_-|glycogen-debranching-protein-GlgX
MMPIRDGEPTPRGASYDGKGVNFSLFSQHAGRVELCLFDDDDVETRLDLPARSGDTWHGYLPAVRPGQRYGYRVHGPWQPQQGLRFNPAKLLLDPCARGIEGDVSDNPCFQCGEEQPDTLDSGPMAPKSVVLADDFDWEGDSCPRTPWGSTVIYEAHVRGLTQLHSAIPAEMRGTYAALGHPVMIDYFQRLGITSLQLLPVASFASEPRLLRLGLSNYWGYNPLACYALESRYACGQNPREEFQQAVKTLHQAGIEVILDVVFNHSAELDESGPTLSMRGIDNPSYYWLDEQGNYANWTGCGNTQNLSHPELVASTIDCLHYWVEECHIDGFRFDLATTLGRTPEYRRDAPLFRAIAADPLLSQCKIIAEPWDIGPCGYQVGNFPLPFAEWNDHFRDTARRYWLHGDLSNGDFARRFAASSDLFQREGRLPSRSLNYITGHDGFTLRDVVSFEHKHNEANGEDNRDGSNNNFSYNHGVEGLHAPLLVTEHRRRSVHALLTTLLLAQGTPMLLAGDEHGHSQHGNNNAYCQDNLLTWLDWKHGDRGLFSFTAALIHLRRRIPALQQDCWWQEGDGNVEWLNGQGRPLNRLEWEQGVHRMQIRISKQWLITLNATEEVCDLVLPPGQWHAIPPFAGEDNPILLTVWHGAAQGVCVFQEKI
>NC_012214.1|WP_015899125.1|3772095_3774282_-|1,4-alpha-glucan-branching-enzyme
MSELVDSRVINAVVSGHFADPFSVLGMHQTRLGLEVRALLPDASEVWVIDTRTGNQCVQLECLDARGFFQAVIPRRKKPFRYQLAVTWHGQQNLIDDAWRFGPLLPEMDSWLLAEGTHLRPYETLGAHGTMIDGVAGTRFAVWAPNAQRVSVVGEFNYWDGRRHPMRLRREMGVWELFIPAARDGQLYKFEIIDNHGQLRLKADPYAFEAQMRPQSASMICGIPEKTRLSPQRQRANGFDAPISIYEVHLGSWRRHTDNHFWLSYQELAQQLVPYAKEMGFTHLELMPVNEHPFDGSWGYQPLGMYAPTRRFGTRDDFRAFITAAHQAGLNVLLDWVPGHFPADDFGLAKFDGSELYEHGDPREGFHQDWNTLIYNFGRREVSNYLAGNALYWIERFGIDGLRVDAVASMIYRDYSRANGEWVPNHFGGRENLEAIAFLRYTNRTLGHAAPGAITIAEESTDFNGVSRPPETGGLGFWFKWDLGWMHDTLDYMKLDPLYRRHHHNLMTFGMLYNNTENFVLPLSHDEVVHGKGSILDRMPGDDWQKFANLRAYYGWMFGFPGKKLLFMGNEFAQGKEWNHDTSLDWHLLEGKDGWHHGVQRLVRDLNHTYRAHPPLYQQDFDPAGFEWLVVDDVDNSVFVFVRRDCDGNELIVASNFTPVPRHGYRFGVSQAGRWREVLNTDSGHYHGSNMGNLGAVSTDDWGSHNRSHSLSLTLPPLATLWLVREAQ
>NC_012214.1|WP_014539734.1|3774694_3775804_-|aspartate-semialdehyde-dehydrogenase
MKTVGLIGWRGMVGSVLMQRMSEERDFDVIRPVFFSTSQHGQAAPAFGGQSAGILQDASDIEALKALDIIITCQGGDYTSDIYPELRAAGWQGYWIDAASTLRMADDAIIILDPVNHQVIRDGLERGIKTFVGGNCTVSLMLMSLGGLFANNLVEWVSVATYQAASGGGARHMRELLTQMGMLHDNVAKELQNPASAILDIERKVTEMGRSGVLPTDNFGVPLAGSLIPWIDKQLDNGQTREEWKGQAETNKILRTSHAIPVDGLCVRVGALRCHSQAFTLKLKKDLPLAEIERLLGDHNPWVKVVPNDRDITLRELTPAAVTGTLNTPVGRLRKLNMGPEYLSAFTVGDQLLWGAAEPLRRMLRLLVD
>NC_012214.1|WP_014539735.1|3775989_3777330_-|gluconate-transporter
MSTATLVLTAAGSVLLLLFLVMKARMHAFVALMLVSIGAGLFSGMPLDKIAETMQKGMGGTLGFLAIVVALGAMFGKILHETGAVDQIAIRMLKTFGESRAHYAMGIAGLICALPLFFEVAVVLLISIAFAVARRTGDNLVKLVIPLFAGVAAAAAFLLPGPAPMLLASQMHADFGWMILLGLCAAIPGMLIAGPLFGRFISQHVQFGLPAEGSHPEFDESKLPSFGFSLSLILFPLILVGLKTIGARFTTPGSSLYQWLEFIGHPFTAILLACLVAIYGLAYRQGMGKERVMQICGAALQPAGIILLVIGAGGVFKQVLVDSGVGPALGNALTGAGLPVALACFVLAGAVRIIQGSATVACLTAVGLIMPVIEPLHYSGAQMAALSICIAGGSVIFSHVNDAGFWLFGRFTGASEGQTLKTWTLMETLLGTVGAIIGMIAFELLS
>NC_012214.1|WP_015899127.1|3777326_3777875_-|gluconokinase
MTTFSPSNHVFVLMGVSGSGKSAVANAVAYRLKAAFLDGDFLHPRVNIEKMSAGHPLDDDDRRPWLQAINDAAFAMQRTNAISLIVCSALKKSYRDILRKGNPNLSFVYLKGDADTIESRLRARKGHFFKPQMLVTQFATLEQPGDDENDVRVVDIHQPLDAVVATTLKTIDAAITQISTAP
>NC_012214.1|WP_015899128.1|3778111_3779107_-|gluconate-operon-transcriptional-repressor-GntR
MKKKRPGLQDVADRVGITKMTVSRYLRNPERVSAALQSKIAAALDALGYIPNRAPDMLSNATSRAIGVLLPSLTNQVFADVLRGIEAVTDAAGYQTLLGHFGYSAEKEELQLRSLLAWNIDGLILTERNHTAASLRMIETAGIPVVETMDCISPCLDMAVGIDNVEAARQMTQAILQKGHRHTVYLGARLDERTLQKEQGYRLAMLDAGLEPKSVMMEAASSFSAGAMLLCEAQKRYPQTDSLFCTNDDLAVGAMFECQRQGLRVPQQMAIAGFHGHDIAQVVTPRLATVQTPRERIGCQAARLLLARIRGEHVTHQPVDVGFTISPGESI
>NC_012214.1|WP_014539738.1|3779307_3780003_-|pirin-family-protein
MIYLRKAQDRGHANHGWLDSYHTFSFADYHDARFMGFSALRVINEDVIDAGQGFGTHPHKDMEILTYVLSGTVEHQDSMGNKEQIPAGEFQIMSAGSGVRHSEYNASKTVALHLYQIWIIPERSGIEPRYEQRRFDDAQGRQLVLSPDAREGSLKVYQDMTLSRWALQAGEQGSIDVADGRRIWIQVVKGEVTVNGEQASTSDALAIWDEQSLAITAGSAAEILVFDLPAV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP048112	Klebsiella michiganensis strain BD177 plasmid unnamed6	22926-22957	0	1.0
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP045219	Pantoea dispersa strain BJQ0007 plasmid unnamed3, complete sequence	28548-28579	0	1.0
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP026384	Serratia sp. SSNIH1 plasmid pSER-840e, complete sequence	19377-19408	0	1.0
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP035200	Klebsiella pneumoniae strain LH375 plasmid pLH375-3, complete sequence	10709-10740	0	1.0
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP045693	Klebsiella pneumoniae strain TK421 plasmid pTK421_3, complete sequence	16554-16585	0	1.0
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	CP052480	Klebsiella pneumoniae strain C16KP0050 plasmid pC16KP0050-4, complete sequence	16405-16436	0	1.0
NC_012214_3	3.3\|941367\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941367-941398	32	NZ_CP017585	Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ04, complete sequence	18301-18332	0	1.0
NC_012214_3	3.3\|941367\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941367-941398	32	NZ_CP017587	Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ06, complete sequence	13400-13431	0	1.0
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP026280	Klebsiella oxytoca strain KONIH2 plasmid pKPC-55bf, complete sequence	146178-146209	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NC_005814	Yersinia pestis biovar Microtus str. 91001 plasmid pCRY, complete sequence	15397-15428	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP048112	Klebsiella michiganensis strain BD177 plasmid unnamed6	9238-9269	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP041104	Klebsiella pneumoniae subsp. pneumoniae strain KPCTRSRTH07 plasmid unnamed5, complete sequence	34107-34138	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP018922	Serratia marcescens strain UMH7 plasmid unnamed5, complete sequence	3548-3579	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP022119	Salmonella enterica subsp. enterica serovar Macclesfield str. S-1643 plasmid unnamed2, complete sequence	13268-13299	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP022119	Salmonella enterica subsp. enterica serovar Macclesfield str. S-1643 plasmid unnamed2, complete sequence	19076-19107	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP026388	Leclercia sp. LSNIH3 plasmid pLEC-2975, complete sequence	30490-30521	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP026384	Serratia sp. SSNIH1 plasmid pSER-840e, complete sequence	32831-32862	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP035200	Klebsiella pneumoniae strain LH375 plasmid pLH375-3, complete sequence	24189-24220	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NC_010726	Klebsiella pneumoniae plasmid pMET-1, complete sequence	15369-15400	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP019191	Salmonella enterica subsp. enterica serovar Poona str. ATCC BAA-1673 plasmid pATCCBAA1673_02, complete sequence	27425-27456	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP045693	Klebsiella pneumoniae strain TK421 plasmid pTK421_3, complete sequence	3100-3131	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	CP052480	Klebsiella pneumoniae strain C16KP0050 plasmid pC16KP0050-4, complete sequence	2955-2986	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	MN823994	Leclercia adecarboxylata strain 150707804 plasmid p707804-2FII, complete sequence	9849-9880	1	0.969
NC_012214_3	3.8\|941673\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941673-941704	32	FQ482085	Erwinia tasmaniensis phage phiEt88 complete genome	24940-24971	1	0.969
NC_012214_3	3.8\|941673\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941673-941704	32	NC_015295	Erwinia phage phiEt88, complete genome	24940-24971	1	0.969
NC_012214_4	4.4\|951697\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951697-951728	32	NZ_KU176944	Citrobacter freundii strain WCHCF65 plasmid pKPC2_CF65, complete sequence	11131-11162	1	0.969
NC_012214_4	4.4\|951697\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951697-951728	32	NZ_CP030267	Klebsiella pneumoniae subsp. pneumoniae strain SC-7 plasmid pSC7-KPC, complete sequence	22652-22683	1	0.969
NC_012214_4	4.4\|951697\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951697-951728	32	NZ_CP028389	Klebsiella pneumoniae strain WCHKP13F2 plasmid pKPC2_095132, complete sequence	85503-85534	1	0.969
NC_012214_4	4.4\|951697\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951697-951728	32	NZ_CP043008	Citrobacter portucalensis strain WCHCP085039 plasmid pKPC2_085039, complete sequence	3339-3370	1	0.969
NC_012214_4	4.5\|951757\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951757-951788	32	FQ482085	Erwinia tasmaniensis phage phiEt88 complete genome	44677-44708	1	0.969
NC_012214_4	4.5\|951757\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951757-951788	32	NC_015295	Erwinia phage phiEt88, complete genome	44677-44708	1	0.969
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP032236	Yersinia ruckeri strain NHV_3758 plasmid pYR4, complete sequence	11173-11204	1	0.969
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP013915	Serratia fonticola strain GS2 plasmid pSF002, complete sequence	69140-69171	1	0.969
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_LN681230	Yersinia ruckeri strain CSF007-82 plasmid pYR3, complete sequence	39618-39649	1	0.969
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP045219	Pantoea dispersa strain BJQ0007 plasmid unnamed3, complete sequence	15075-15106	2	0.938
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	CP032292	UNVERIFIED_ORG: Enterobacter cloacae strain AR_0073 plasmid unnamed1, complete sequence	36007-36038	2	0.938
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP019446	Kosakonia cowanii JCM 10956 = DSM 18146 strain 888-76 plasmid p888-76-1, complete sequence	9209-9240	3	0.906
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP040393	Kosakonia radicincitans strain DSM 107547 plasmid pKrDSM107547, complete sequence	76283-76314	3	0.906
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP022661	Salmonella enterica subsp. enterica strain RM11065 plasmid pRM11065-1, complete sequence	32884-32915	4	0.875
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	CP053403	Salmonella enterica strain 2010K-2057 plasmid unnamed1, complete sequence	5375-5406	4	0.875
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP022492	Salmonella enterica subsp. enterica serovar Saintpaul strain SA20031783 plasmid unnamed1, complete sequence	44726-44757	4	0.875
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP019182	Salmonella enterica subsp. enterica serovar Inverness str. ATCC 10720 plasmid pATCC10720, complete sequence	22333-22364	4	0.875
NC_012214_6	6.9\|962195\|36\|NC_012214\|CRISPRCasFinder	962195-962230	36	NZ_CP032236	Yersinia ruckeri strain NHV_3758 plasmid pYR4, complete sequence	11169-11204	5	0.861
NC_012214_6	6.9\|962195\|36\|NC_012214\|CRISPRCasFinder	962195-962230	36	NZ_CP013915	Serratia fonticola strain GS2 plasmid pSF002, complete sequence	69136-69171	5	0.861
NC_012214_6	6.9\|962195\|36\|NC_012214\|CRISPRCasFinder	962195-962230	36	NZ_LN681230	Yersinia ruckeri strain CSF007-82 plasmid pYR3, complete sequence	39618-39653	5	0.861
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP024882	Citrobacter freundii strain AR_0022 plasmid unitig_1_pilon, complete sequence	15375-15406	5	0.844
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	CP053577	Salmonella enterica strain 2012K-0845 plasmid unnamed2, complete sequence	137908-137939	5	0.844
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP032180	Citrobacter freundii strain AR_0116 plasmid unnamed2, complete sequence	16574-16605	5	0.844
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP037863	Citrobacter sp. LY-1 plasmid unnamed2, complete sequence	84388-84419	5	0.844
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	MN693155	Marine virus AFVG_25M94, complete genome	27150-27181	6	0.812
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	MN694517	Marine virus AFVG_250M306, complete genome	47464-47495	6	0.812
NC_012214_4	4.7\|951877\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951877-951908	32	FQ482085	Erwinia tasmaniensis phage phiEt88 complete genome	41069-41100	6	0.812
NC_012214_4	4.7\|951877\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951877-951908	32	NC_015295	Erwinia phage phiEt88, complete genome	41069-41100	6	0.812
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP050099	Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence	16656-16687	6	0.812
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP053441	Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence	16656-16687	6	0.812
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP018230	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed2, complete sequence	387894-387925	6	0.812
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP016289	Rhizobium leguminosarum strain Vaf10 plasmid unnamed2, complete sequence	261046-261077	6	0.812
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP022566	Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK02, complete sequence	282576-282607	6	0.812
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP034939	Pectobacterium odoriferum strain JK2.1 plasmid p.Jk2_1, complete sequence	31037-31068	6	0.812
NC_012214_2	2.9\|930901\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930901-930932	32	NZ_CP054609	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed1, complete sequence	226319-226350	7	0.781
NC_012214_2	2.9\|930901\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930901-930932	32	AY048850	Natrinema virus SNJ1, complete genome	11267-11298	7	0.781
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP043858	Arcobacter cibarius strain H743 plasmid pACIB, complete sequence	28647-28678	7	0.781
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	MN582060	Podoviridae sp. ctg2L5, complete genome	21461-21492	7	0.781
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NC_017421	Borreliella burgdorferi N40 plasmid N40_lp38, complete sequence	15870-15901	7	0.781
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NC_001856	Borreliella burgdorferi B31 plasmid lp38, complete sequence	15578-15609	7	0.781
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP019853	Borreliella burgdorferi plasmid lp38, complete sequence	15591-15622	7	0.781
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP019764	Borreliella burgdorferi strain B31_NRZ isolate B31 plasmid p_lp38, complete sequence	15584-15615	7	0.781
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP017217	Borreliella burgdorferi strain B331 plasmid B331_lp38, complete sequence	15666-15697	7	0.781
NC_012214_3	3.13\|941978\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941978-942009	32	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	2010483-2010514	7	0.781
NC_012214_3	3.13\|941978\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941978-942009	32	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	1616821-1616852	7	0.781
NC_012214_3	3.14\|942039\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	942039-942070	32	MN855819	Bacteriophage sp. isolate 156, complete genome	11249-11280	7	0.781
NC_012214_4	4.8\|951937\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951937-951968	32	KX397365	Erwinia phage vB_EamM_Caitlin, complete genome	31347-31378	7	0.781
NC_012214_5	5.1\|952340\|32\|NC_012214\|CRISPRCasFinder	952340-952371	32	NZ_CP044357	Acinetobacter baumannii strain CAM180-1 plasmid pCAM180A, complete sequence	22780-22811	7	0.781
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP050093	Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b5, complete sequence	16812-16843	7	0.781
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP050082	Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence	17805-17836	7	0.781
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NC_008384	Rhizobium leguminosarum bv. viciae 3841 plasmid pRL11, complete sequence	16818-16849	7	0.781
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP049732	Rhizobium leguminosarum strain A1 plasmid pRL11, complete sequence	16759-16790	7	0.781
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP013634	Rhizobium sp. N324 plasmid pRspN324d, complete sequence	13141-13172	7	0.781
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NC_012858	Rhizobium leguminosarum bv. trifolii WSM1325 plasmid pR132502, complete sequence	574962-574993	7	0.781
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NC_011366	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG202, complete sequence	430467-430498	7	0.781
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP054023	Rhizobium sp. JKLM12A2 plasmid pPR12A202, complete sequence	283203-283234	7	0.781
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP054033	Rhizobium sp. JKLM13E plasmid pPR13E02, complete sequence	442890-442921	7	0.781
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP053208	Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1B, complete sequence	16757-16788	7	0.781
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NC_016907	Gordonia polyisoprenivorans VH2 plasmid p174, complete sequence	113459-113490	7	0.781
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	952547-952578	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP025983	Enterobacteriaceae bacterium A-F18 plasmid pAF18_1, complete sequence	69939-69970	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP017586	Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ05, complete sequence	17724-17755	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NC_023025	Cronobacter malonaticus plasmid p2, complete sequence	52970-53001	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP011050	Cronobacter sakazakii strain ATCC 29544 plasmid CSK29544_3p, complete sequence	9164-9195	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NC_013285	Cronobacter turicensis z3032 plasmid pCTU3, complete sequence	10285-10316	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP039454	Enterobacter bugandensis strain 220 plasmid pSurvcare220, complete sequence	145914-145945	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP017590	Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ09, complete sequence	48138-48169	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP019840	Enterobacter roggenkampii strain R11 plasmid pASM1, complete sequence	52804-52835	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP022149	Enterobacter roggenkampii strain 704SK10 plasmid p704SK10_1, complete sequence	110922-110953	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP009855	UNVERIFIED_ORG: Enterobacter cloacae strain ECNIH5 plasmid pENT-22e, complete sequence	77877-77908	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP008907	Enterobacter hormaechei subsp. hoffmannii ECR091 plasmid pENT-4bd, complete sequence	35243-35274	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP033798	Enterobacter roggenkampii strain FDAARGOS_523 plasmid unnamed2, complete sequence	43943-43974	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP026851	UNVERIFIED_ORG: Enterobacter cloacae strain AR_0072 plasmid unnamed1	104457-104488	7	0.781
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP029719	UNVERIFIED_ORG: Enterobacter cloacae strain AR_0154 plasmid unnamed1, complete sequence	43380-43411	7	0.781
NC_012214_2	2.1\|930412\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	930412-930443	32	NC_048768	Gordonia phage Chelms, complete genome	1429-1460	8	0.75
NC_012214_2	2.1\|930412\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	930412-930443	32	MT986029	Gordonia phage Linetti, complete genome	1427-1458	8	0.75
NC_012214_4	4.3\|951637\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951637-951668	32	NZ_CP040754	Sulfitobacter sp. BSw21498 plasmid unnamed, complete sequence	84931-84962	8	0.75
NC_012214_4	4.4\|951697\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951697-951728	32	LT615366	Enterococcus phage VPE25 genome assembly, chromosome: VPE25	58462-58493	8	0.75
NC_012214_4	4.4\|951697\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951697-951728	32	LT546029	Enterococcus phage VFW genome assembly, chromosome: VFW	57731-57762	8	0.75
NC_012214_4	4.4\|951697\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951697-951728	32	LT546030	Enterococcus phage VPE25 genome assembly, chromosome: I	58462-58493	8	0.75
NC_012214_4	4.4\|951697\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951697-951728	32	MT119361	Enterococus phage vipetofem, complete genome	27499-27530	8	0.75
NC_012214_4	4.5\|951757\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951757-951788	32	NZ_CP029832	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed2, complete sequence	568638-568669	8	0.75
NC_012214_5	5.1\|952340\|32\|NC_012214\|CRISPRCasFinder	952340-952371	32	MN855600	Bacteriophage sp. isolate 296, complete genome	5661-5692	8	0.75
NC_012214_5	5.1\|952340\|32\|NC_012214\|CRISPRCasFinder	952340-952371	32	NZ_CP014237	Moraxella osloensis strain CCUG 350 plasmid unnamed2, complete sequence	28721-28752	8	0.75
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP050105	Rhizobium leguminosarum bv. trifolii strain 4B plasmid pRL4b6, complete sequence	16788-16819	8	0.75
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP025508	Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvB, complete sequence	16688-16719	8	0.75
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP050110	Rhizobium leguminosarum bv. trifolii strain 3B plasmid pRL3b4, complete sequence	16788-16819	8	0.75
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP030764	Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed4, complete sequence	553349-553380	8	0.75
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP022667	Rhizobium leguminosarum bv. viciae strain BIHB 1217 plasmid pPR2, complete sequence	23595-23626	8	0.75
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP050087	Rhizobium leguminosarum bv. trifolii strain 23B plasmid pRL23b5, complete sequence	16687-16718	8	0.75
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NC_021289	Burkholderia insecticola plasmid p1, complete sequence	1231205-1231236	8	0.75
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP054029	Rhizobium sp. JKLM19E plasmid pPR19E02, complete sequence	360142-360173	8	0.75
NC_012214_6	6.3\|962079\|32\|NC_012214\|PILER-CR,CRT	962079-962110	32	NC_015163	Deinococcus proteolyticus MRP plasmid pDEIPR04, complete sequence	5291-5322	8	0.75
NC_012214_6	6.3\|962079\|32\|NC_012214\|PILER-CR,CRT	962079-962110	32	NC_015162	Deinococcus proteolyticus MRP plasmid pDEIPR02, complete sequence	156203-156234	8	0.75
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NC_016515	Enterobacter ludwigii strain EcWSU1 plasmid pEcWSU1_A, complete sequence	1370-1401	8	0.75
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP033799	Enterobacter roggenkampii strain FDAARGOS_523 plasmid unnamed3, complete sequence	6468-6499	8	0.75
NC_012214_6	6.10\|962199\|32\|NC_012214\|CRT	962199-962230	32	NZ_CP022534	Enterobacter hormaechei strain MS7884A plasmid pMS7884B, complete sequence	63987-64018	8	0.75
NC_012214_2	2.2\|930473\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	930473-930504	32	MT774378	CrAssphage cr106_1, complete genome	54055-54086	9	0.719
NC_012214_2	2.7\|930779\|32\|NC_012214\|CRISPRCasFinder,CRT	930779-930810	32	NZ_CP045959	Salmonella enterica subsp. enterica serovar Birkenhead strain AUSMDU00010532 plasmid pAUSMDU00010532_01, complete sequence	62168-62199	9	0.719
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP044456	Acinetobacter indicus strain B18 plasmid pB18-1, complete sequence	202517-202548	9	0.719
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP039144	Acinetobacter sp. 10FS3-1 plasmid p10FS3-1-1, complete sequence	25981-26012	9	0.719
NC_012214_3	3.4\|941428\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941428-941459	32	NZ_CP045341	Vibrio sp. THAF190c plasmid pTHAF190c_c, complete sequence	12640-12671	9	0.719
NC_012214_3	3.10\|941795\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941795-941826	32	NC_011143	Phenylobacterium zucineum HLK1 plasmid, complete sequence	338920-338951	9	0.719
NC_012214_4	4.5\|951757\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951757-951788	32	NC_005241	Cupriavidus necator H16 megaplasmid pHG1, complete sequence	301683-301714	9	0.719
NC_012214_4	4.5\|951757\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951757-951788	32	NZ_CP039289	Cupriavidus necator H16 plasmid pHG1, complete sequence	301682-301713	9	0.719
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	890358-890389	9	0.719
NC_012214_6	6.2\|962019\|32\|NC_012214\|PILER-CR,CRT	962019-962050	32	NZ_CP022416	Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-1, complete sequence	403647-403678	9	0.719
NC_012214_6	6.3\|962079\|32\|NC_012214\|PILER-CR,CRT	962079-962110	32	MH727545	Mycobacterium phage DismalStressor, complete genome	33728-33759	9	0.719
NC_012214_6	6.3\|962079\|32\|NC_012214\|PILER-CR,CRT	962079-962110	32	NC_026598	Mycobacterium phage Milly, complete genome	33701-33732	9	0.719
NC_012214_6	6.3\|962079\|32\|NC_012214\|PILER-CR,CRT	962079-962110	32	MH834601	Mycobacterium phage BoostSeason, complete genome	33635-33666	9	0.719
NC_012214_6	6.3\|962079\|32\|NC_012214\|PILER-CR,CRT	962079-962110	32	KX688047	Mycobacterium phage Marcoliusprime, complete genome	33728-33759	9	0.719
NC_012214_6	6.3\|962079\|32\|NC_012214\|PILER-CR,CRT	962079-962110	32	NC_028759	Mycobacterium phage Mufasa, complete genome	33626-33657	9	0.719
NC_012214_6	6.3\|962079\|32\|NC_012214\|PILER-CR,CRT	962079-962110	32	MF140408	Mycobacterium phage DismalFunk, complete genome	33728-33759	9	0.719
NC_012214_6	6.3\|962079\|32\|NC_012214\|PILER-CR,CRT	962079-962110	32	MF140411	Mycobacterium phage Findley, complete genome	33721-33752	9	0.719
NC_012214_6	6.3\|962079\|32\|NC_012214\|PILER-CR,CRT	962079-962110	32	NZ_CP031159	Deinococcus wulumuqiensis strain NEB 479 plasmid pDrdA, complete sequence	31578-31609	9	0.719
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NZ_CP018230	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed2, complete sequence	387890-387925	9	0.75
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NZ_CP016289	Rhizobium leguminosarum strain Vaf10 plasmid unnamed2, complete sequence	261042-261077	9	0.75
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NZ_CP022566	Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK02, complete sequence	282572-282607	9	0.75
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NZ_CP050099	Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence	16656-16691	9	0.75
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NZ_CP053441	Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence	16656-16691	9	0.75
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP021931	Lactobacillus plantarum strain TMW 1.1308 plasmid pL11308-1, complete sequence	70071-70102	10	0.688
NC_012214_2	2.10\|930962\|32\|NC_012214\|CRISPRCasFinder,CRT,PILER-CR	930962-930993	32	NZ_CP050806	Lactobacillus plantarum strain SPC-SNU 72-2 plasmid pLBP752, complete sequence	51436-51467	10	0.688
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP024444	Moraxella osloensis strain NP7 plasmid pNP7-1, complete sequence	71485-71516	10	0.688
NC_012214_3	3.2\|941306\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	941306-941337	32	NZ_CP040258	Moraxella osloensis strain MOXF1 plasmid pMOXF1, complete sequence	90406-90437	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	CP051632	Escherichia coli O121 strain FDA858783-1-52 plasmid pFNW19M81, complete sequence	21170-21201	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP028113	Escherichia coli O103 str. RM8385 plasmid pRM8385-1, complete sequence	48762-48793	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP031911	Escherichia coli O121:H19 strain FWSEC0006 plasmid unnamed15, complete sequence	53580-53611	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP031923	Escherichia coli O26:H11 strain FWSEC0001 plasmid unnamed6, complete sequence	45777-45808	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027220	Escherichia coli strain 2015C-3163 plasmid unnamed, complete sequence	79730-79761	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027578	Escherichia coli strain 2013C-4225 plasmid unnamed	57246-57277	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027350	Escherichia coli strain 2014C-3655 plasmid unnamed	52209-52240	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP037944	Escherichia coli strain CFSAN027343 plasmid pCFSAN027343, complete sequence	85428-85459	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027547	Escherichia coli strain 2013C-4187 plasmid unnamed, complete sequence	50297-50328	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027391	Escherichia coli strain 2015C-4944 plasmid unnamed, complete sequence	36970-37001	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NC_012487	Escherichia coli plasmid pO26-Vir, complete sequence	38989-39020	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027444	Escherichia coli strain 2013C-3252 plasmid unnamed2, complete sequence	32270-32301	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027473	Escherichia coli strain 2014C-3050 plasmid unnamed	26768-26799	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NC_013728	Escherichia coli O26:H- plasmid pO26-CRL, complete sequence	36976-37007	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027601	Escherichia coli strain 97-3250 plasmid unnamed2	76680-76711	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027436	Escherichia coli strain 2014C-3599 plasmid unnamed, complete sequence	45979-46010	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP006028	Escherichia coli O145:H28 str. RM13514 plasmid pO145-13514, complete sequence	54549-54580	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	AP019709	Escherichia coli O145:H28 122715 plasmid pO145_122715_1 DNA, complete genome	31674-31705	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027456	Escherichia coli strain 2014C-4423 plasmid unnamed2, complete sequence	64075-64106	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_AP018810	Escherichia coli strain E2865 plasmid pE2865-2, complete sequence	31449-31480	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP037946	Escherichia coli strain CFSAN027346 plasmid pCFSAN027346-1, complete sequence	80760-80791	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	AP019707	Escherichia coli O145:H28 112648 plasmid pO145_112648_1 DNA, complete genome	31674-31705	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027764	Escherichia coli strain 2015C-3125 plasmid unnamed1	26600-26631	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027339	Escherichia coli strain 2014C-3051 plasmid unnamed, complete sequence	8430-8461	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027556	Escherichia coli strain 2013C-3513 plasmid unnamed2	32599-32630	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027386	Escherichia coli strain 2014C-3057 plasmid unnamed	40779-40810	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027354	Escherichia coli strain 2012C-4606 plasmid unnamed2	30692-30723	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027583	Escherichia coli strain 2013C-4538 plasmid unnamed	57151-57182	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP027318	Escherichia coli strain 2015C-3107 plasmid unnamed, complete sequence	3765-3796	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NC_013369	Escherichia coli O26:H11 str. 11368 plasmid pO26_1, complete sequence	32096-32127	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	AP019704	Escherichia coli O145:H28 10942 plasmid pO145_10942_1 DNA, complete genome	31674-31705	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP022408	Escherichia coli O121:H19 strain 16-9255 plasmid punamed1, complete sequence	52027-52058	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP028115	Escherichia coli O26 str. RM8426 plasmid pRM8426, complete sequence	32096-32127	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP028380	Escherichia coli O145 str. RM9872 plasmid pRM9872-1, complete sequence	57367-57398	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	CP027321	Escherichia coli strain 2014C-3084 plasmid unnamed2	26176-26207	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	CP027359	Escherichia coli strain 2014C-4639 plasmid unnamed1	27599-27630	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP031920	Escherichia coli O145:NM strain FWSEC0002 plasmid unnamed9, complete sequence	43099-43130	10	0.688
NC_012214_4	4.2\|951577\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951577-951608	32	NZ_CP028111	Escherichia coli O121 str. RM8352 plasmid pRM8352, complete sequence	71415-71446	10	0.688
NC_012214_4	4.3\|951637\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951637-951668	32	NZ_CP011248	Agrobacterium tumefaciens strain Ach5 plasmid pAt, complete sequence	184632-184663	10	0.688
NC_012214_4	4.3\|951637\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951637-951668	32	NZ_CP032919	Agrobacterium tumefaciens strain 15955 plasmid pAt15955, complete sequence	184393-184424	10	0.688
NC_012214_4	4.3\|951637\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951637-951668	32	NZ_CP033029	Agrobacterium tumefaciens strain A6 plasmid pAtA6, complete sequence	184477-184508	10	0.688
NC_012214_4	4.5\|951757\|32\|NC_012214\|PILER-CR,CRISPRCasFinder,CRT	951757-951788	32	NC_017273	Thermus thermophilus SG0.5JP17-16 plasmid pTHTHE1601, complete sequence	373760-373791	10	0.688
NC_012214_6	6.1\|961959\|32\|NC_012214\|PILER-CR,CRT	961959-961990	32	NC_016108	Methylomicrobium alcaliphilum 20Z plasmid MEALZ_p, complete sequence	57799-57830	10	0.688
NC_012214_6	6.3\|962079\|32\|NC_012214\|PILER-CR,CRT	962079-962110	32	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	785798-785829	10	0.688
NC_012214_6	6.3\|962079\|32\|NC_012214\|PILER-CR,CRT	962079-962110	32	NZ_CP043439	Cupriavidus campinensis strain MJ1 plasmid unnamed2, complete sequence	152054-152085	10	0.688
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NC_012858	Rhizobium leguminosarum bv. trifolii WSM1325 plasmid pR132502, complete sequence	574958-574993	10	0.722
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NC_011366	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG202, complete sequence	430463-430498	10	0.722
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NZ_CP050093	Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b5, complete sequence	16812-16847	10	0.722
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NZ_CP050082	Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence	17805-17840	10	0.722
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NC_008384	Rhizobium leguminosarum bv. viciae 3841 plasmid pRL11, complete sequence	16818-16853	10	0.722
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NZ_CP049732	Rhizobium leguminosarum strain A1 plasmid pRL11, complete sequence	16759-16794	10	0.722
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NZ_CP013634	Rhizobium sp. N324 plasmid pRspN324d, complete sequence	13141-13176	10	0.722
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NZ_CP054023	Rhizobium sp. JKLM12A2 plasmid pPR12A202, complete sequence	283203-283238	10	0.722
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NZ_CP054033	Rhizobium sp. JKLM13E plasmid pPR13E02, complete sequence	442890-442925	10	0.722
NC_012214_6	6.5\|961955\|36\|NC_012214\|CRISPRCasFinder	961955-961990	36	NZ_CP053208	Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1B, complete sequence	16757-16792	10	0.722
NC_012214_6	6.6\|962015\|36\|NC_012214\|CRISPRCasFinder	962015-962050	36	NZ_CP022416	Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-1, complete sequence	403643-403678	11	0.694

1. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP048112 (Klebsiella michiganensis strain BD177 plasmid unnamed6) position: , mismatch: 0, identity: 1.0

ctttgatgataattttcttgcttctattacta	CRISPR spacer
ctttgatgataattttcttgcttctattacta	Protospacer
********************************

2. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP045219 (Pantoea dispersa strain BJQ0007 plasmid unnamed3, complete sequence) position: , mismatch: 0, identity: 1.0

ctttgatgataattttcttgcttctattacta	CRISPR spacer
ctttgatgataattttcttgcttctattacta	Protospacer
********************************

3. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP026384 (Serratia sp. SSNIH1 plasmid pSER-840e, complete sequence) position: , mismatch: 0, identity: 1.0

ctttgatgataattttcttgcttctattacta	CRISPR spacer
ctttgatgataattttcttgcttctattacta	Protospacer
********************************

4. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP035200 (Klebsiella pneumoniae strain LH375 plasmid pLH375-3, complete sequence) position: , mismatch: 0, identity: 1.0

ctttgatgataattttcttgcttctattacta	CRISPR spacer
ctttgatgataattttcttgcttctattacta	Protospacer
********************************

5. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP045693 (Klebsiella pneumoniae strain TK421 plasmid pTK421_3, complete sequence) position: , mismatch: 0, identity: 1.0

ctttgatgataattttcttgcttctattacta	CRISPR spacer
ctttgatgataattttcttgcttctattacta	Protospacer
********************************

6. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to CP052480 (Klebsiella pneumoniae strain C16KP0050 plasmid pC16KP0050-4, complete sequence) position: , mismatch: 0, identity: 1.0

ctttgatgataattttcttgcttctattacta	CRISPR spacer
ctttgatgataattttcttgcttctattacta	Protospacer
********************************

7. spacer 3.3|941367|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017585 (Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ04, complete sequence) position: , mismatch: 0, identity: 1.0

acagtcaaccagtaccactccatttttttcgt	CRISPR spacer
acagtcaaccagtaccactccatttttttcgt	Protospacer
********************************

8. spacer 3.3|941367|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017587 (Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ06, complete sequence) position: , mismatch: 0, identity: 1.0

acagtcaaccagtaccactccatttttttcgt	CRISPR spacer
acagtcaaccagtaccactccatttttttcgt	Protospacer
********************************

9. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026280 (Klebsiella oxytoca strain KONIH2 plasmid pKPC-55bf, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

10. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_005814 (Yersinia pestis biovar Microtus str. 91001 plasmid pCRY, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

11. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP048112 (Klebsiella michiganensis strain BD177 plasmid unnamed6) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

12. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP041104 (Klebsiella pneumoniae subsp. pneumoniae strain KPCTRSRTH07 plasmid unnamed5, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

13. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018922 (Serratia marcescens strain UMH7 plasmid unnamed5, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

14. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022119 (Salmonella enterica subsp. enterica serovar Macclesfield str. S-1643 plasmid unnamed2, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

15. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022119 (Salmonella enterica subsp. enterica serovar Macclesfield str. S-1643 plasmid unnamed2, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

16. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026388 (Leclercia sp. LSNIH3 plasmid pLEC-2975, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

17. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026384 (Serratia sp. SSNIH1 plasmid pSER-840e, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

18. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP035200 (Klebsiella pneumoniae strain LH375 plasmid pLH375-3, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

19. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_010726 (Klebsiella pneumoniae plasmid pMET-1, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

20. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019191 (Salmonella enterica subsp. enterica serovar Poona str. ATCC BAA-1673 plasmid pATCCBAA1673_02, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

21. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045693 (Klebsiella pneumoniae strain TK421 plasmid pTK421_3, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

22. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to CP052480 (Klebsiella pneumoniae strain C16KP0050 plasmid pC16KP0050-4, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

23. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to MN823994 (Leclercia adecarboxylata strain 150707804 plasmid p707804-2FII, complete sequence) position: , mismatch: 1, identity: 0.969

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttcctttt	Protospacer
*** ****************************

24. spacer 3.8|941673|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to FQ482085 (Erwinia tasmaniensis phage phiEt88 complete genome) position: , mismatch: 1, identity: 0.969

acggatgttgatattggggacgtaataggttg	CRISPR spacer
acgaatgttgatattggggacgtaataggttg	Protospacer
***.****************************

25. spacer 3.8|941673|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_015295 (Erwinia phage phiEt88, complete genome) position: , mismatch: 1, identity: 0.969

acggatgttgatattggggacgtaataggttg	CRISPR spacer
acgaatgttgatattggggacgtaataggttg	Protospacer
***.****************************

26. spacer 4.4|951697|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KU176944 (Citrobacter freundii strain WCHCF65 plasmid pKPC2_CF65, complete sequence) position: , mismatch: 1, identity: 0.969

attgacgaaattttgacaacgctgaaactgcc	CRISPR spacer
attgacgaaattttggcaacgctgaaactgcc	Protospacer
***************.****************

27. spacer 4.4|951697|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030267 (Klebsiella pneumoniae subsp. pneumoniae strain SC-7 plasmid pSC7-KPC, complete sequence) position: , mismatch: 1, identity: 0.969

attgacgaaattttgacaacgctgaaactgcc	CRISPR spacer
attgacgaaattttggcaacgctgaaactgcc	Protospacer
***************.****************

28. spacer 4.4|951697|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028389 (Klebsiella pneumoniae strain WCHKP13F2 plasmid pKPC2_095132, complete sequence) position: , mismatch: 1, identity: 0.969

attgacgaaattttgacaacgctgaaactgcc	CRISPR spacer
attgacgaaattttggcaacgctgaaactgcc	Protospacer
***************.****************

29. spacer 4.4|951697|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP043008 (Citrobacter portucalensis strain WCHCP085039 plasmid pKPC2_085039, complete sequence) position: , mismatch: 1, identity: 0.969

attgacgaaattttgacaacgctgaaactgcc	CRISPR spacer
attgacgaaattttggcaacgctgaaactgcc	Protospacer
***************.****************

30. spacer 4.5|951757|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to FQ482085 (Erwinia tasmaniensis phage phiEt88 complete genome) position: , mismatch: 1, identity: 0.969

cccgttgtggctcaaagccggagatcagcacc	CRISPR spacer
cccgttgtgactcaaagccggagatcagcacc	Protospacer
*********.**********************

31. spacer 4.5|951757|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_015295 (Erwinia phage phiEt88, complete genome) position: , mismatch: 1, identity: 0.969

cccgttgtggctcaaagccggagatcagcacc	CRISPR spacer
cccgttgtgactcaaagccggagatcagcacc	Protospacer
*********.**********************

32. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP032236 (Yersinia ruckeri strain NHV_3758 plasmid pYR4, complete sequence) position: , mismatch: 1, identity: 0.969

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aagttgcgaacagatttcggggggtttttgca	Protospacer
****.***************************

33. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP013915 (Serratia fonticola strain GS2 plasmid pSF002, complete sequence) position: , mismatch: 1, identity: 0.969

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aagttgcgaacagatttcggggggtttttgca	Protospacer
****.***************************

34. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_LN681230 (Yersinia ruckeri strain CSF007-82 plasmid pYR3, complete sequence) position: , mismatch: 1, identity: 0.969

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aagttgcgaacagatttcggggggtttttgca	Protospacer
****.***************************

35. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045219 (Pantoea dispersa strain BJQ0007 plasmid unnamed3, complete sequence) position: , mismatch: 2, identity: 0.938

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatgcattttccttat	Protospacer
*** ************************** *

36. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to CP032292 (UNVERIFIED_ORG: Enterobacter cloacae strain AR_0073 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.938

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
gctgaatgcctttgccgatacattttcctttt	Protospacer
*** ***************.************

37. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP019446 (Kosakonia cowanii JCM 10956 = DSM 18146 strain 888-76 plasmid p888-76-1, complete sequence) position: , mismatch: 3, identity: 0.906

aagtcgc-gaacagatttcggggggtttttgca	CRISPR spacer
-agttgctaaacagatttcggggggtttttgca	Protospacer
 ***.** .************************

38. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP040393 (Kosakonia radicincitans strain DSM 107547 plasmid pKrDSM107547, complete sequence) position: , mismatch: 3, identity: 0.906

aagtcgc-gaacagatttcggggggtttttgca	CRISPR spacer
-agttgcttaacagatttcggggggtttttgca	Protospacer
 ***.**  ************************

39. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP022661 (Salmonella enterica subsp. enterica strain RM11065 plasmid pRM11065-1, complete sequence) position: , mismatch: 4, identity: 0.875

-aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
caagattcg-acagatttcggggggtttttgca	Protospacer
 *** . ** ***********************

40. spacer 6.10|962199|32|NC_012214|CRT matches to CP053403 (Salmonella enterica strain 2010K-2057 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.875

-aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
caagattcg-acagatttcggggggtttttgca	Protospacer
 *** . ** ***********************

41. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP022492 (Salmonella enterica subsp. enterica serovar Saintpaul strain SA20031783 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.875

-aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
caagactc-tacagatttcggggggtttttgca	Protospacer
 *** * *  ***********************

42. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP019182 (Salmonella enterica subsp. enterica serovar Inverness str. ATCC 10720 plasmid pATCC10720, complete sequence) position: , mismatch: 4, identity: 0.875

-aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
caagattcg-acagatttcggggggtttttgca	Protospacer
 *** . ** ***********************

43. spacer 6.9|962195|36|NC_012214|CRISPRCasFinder matches to NZ_CP032236 (Yersinia ruckeri strain NHV_3758 plasmid pYR4, complete sequence) position: , mismatch: 5, identity: 0.861

gaaaaagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
cgccaagttgcgaacagatttcggggggtttttgca	Protospacer
 .  ****.***************************

44. spacer 6.9|962195|36|NC_012214|CRISPRCasFinder matches to NZ_CP013915 (Serratia fonticola strain GS2 plasmid pSF002, complete sequence) position: , mismatch: 5, identity: 0.861

gaaaaagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
cgccaagttgcgaacagatttcggggggtttttgca	Protospacer
 .  ****.***************************

45. spacer 6.9|962195|36|NC_012214|CRISPRCasFinder matches to NZ_LN681230 (Yersinia ruckeri strain CSF007-82 plasmid pYR3, complete sequence) position: , mismatch: 5, identity: 0.861

gaaaaagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
cgccaagttgcgaacagatttcggggggtttttgca	Protospacer
 .  ****.***************************

46. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP024882 (Citrobacter freundii strain AR_0022 plasmid unitig_1_pilon, complete sequence) position: , mismatch: 5, identity: 0.844

-aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
caagactc-tacagatttcggggggtttgtgca	Protospacer
 *** * *  ****************** ****

47. spacer 6.10|962199|32|NC_012214|CRT matches to CP053577 (Salmonella enterica strain 2012K-0845 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.844

--aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
caaagt--tgaccagatttcagggggtttttgca	Protospacer
  ****  .** ********.*************

48. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP032180 (Citrobacter freundii strain AR_0116 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.844

-aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
caagactc-tacagatttcggggggtttgtgca	Protospacer
 *** * *  ****************** ****

49. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP037863 (Citrobacter sp. LY-1 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.844

-aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
caagactc-tacagatttcggggggtttgtgca	Protospacer
 *** * *  ****************** ****

50. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to MN693155 (Marine virus AFVG_25M94, complete genome) position: , mismatch: 6, identity: 0.812

ctttgatgataattttcttgcttctattacta	CRISPR spacer
gtataatgctaattttcttgcttctatttctg	Protospacer
 * *.*** ******************* **.

51. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to MN694517 (Marine virus AFVG_250M306, complete genome) position: , mismatch: 6, identity: 0.812

ctttgatgataattttcttgcttctattacta-	CRISPR spacer
aattgatgataattttgttgcatcta-aactaa	Protospacer
  ************** **** ****  ****

52. spacer 4.7|951877|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to FQ482085 (Erwinia tasmaniensis phage phiEt88 complete genome) position: , mismatch: 6, identity: 0.812

ggaaacgaacagcgttttccactgcattaatg	CRISPR spacer
ggaaacaaacagcgttttccactgcgcaaggg	Protospacer
******.******************.. *. *

53. spacer 4.7|951877|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_015295 (Erwinia phage phiEt88, complete genome) position: , mismatch: 6, identity: 0.812

ggaaacgaacagcgttttccactgcattaatg	CRISPR spacer
ggaaacaaacagcgttttccactgcgcaaggg	Protospacer
******.******************.. *. *

54. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP050099 (Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence) position: , mismatch: 6, identity: 0.812

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctatctcgccgaggt	Protospacer
. **************** * ******* * *

55. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP053441 (Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence) position: , mismatch: 6, identity: 0.812

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctacctcgccgaggt	Protospacer
. **************** * ******* * *

56. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP018230 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.812

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctacctcgccgaggt	Protospacer
. **************** * ******* * *

57. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP016289 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.812

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctacctcgccgaggt	Protospacer
. **************** * ******* * *

58. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP022566 (Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK02, complete sequence) position: , mismatch: 6, identity: 0.812

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctacctcgccgaggt	Protospacer
. **************** * ******* * *

59. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP034939 (Pectobacterium odoriferum strain JK2.1 plasmid p.Jk2_1, complete sequence) position: , mismatch: 6, identity: 0.812

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
agaactggtacagatttcggggggtttttgca	Protospacer
*.. *  * ***********************

60. spacer 2.9|930901|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP054609 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.781

aggttagaaacgaacaagtcggcatcaacgcc	CRISPR spacer
agccaagaatcgaacaaggcggcatcaactcg	Protospacer
** . **** ******** ********** *

61. spacer 2.9|930901|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to AY048850 (Natrinema virus SNJ1, complete genome) position: , mismatch: 7, identity: 0.781

aggttagaaacgaacaagtcggcatcaacgcc	CRISPR spacer
acgtgcgaaacgaaaaagtcgacatcaacatc	Protospacer
* **  ******** ******.*******..*

62. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP043858 (Arcobacter cibarius strain H743 plasmid pACIB, complete sequence) position: , mismatch: 7, identity: 0.781

ctttgatgataattttcttgcttctattacta	CRISPR spacer
tcttggtgataattttcttgcatctatttttt	Protospacer
..***.*************** ****** .*

63. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to MN582060 (Podoviridae sp. ctg2L5, complete genome) position: , mismatch: 7, identity: 0.781

ctttgatgataattttcttgcttctattacta-	CRISPR spacer
tattgttgataatattcttgcttctacc-ctac	Protospacer
. *** ******* ************.. ***

64. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NC_017421 (Borreliella burgdorferi N40 plasmid N40_lp38, complete sequence) position: , mismatch: 7, identity: 0.781

ctttgatgataattttcttgcttctattacta	CRISPR spacer
cataggtgataattttcttggttttattaaaa	Protospacer
* * *.************** **.*****  *

65. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NC_001856 (Borreliella burgdorferi B31 plasmid lp38, complete sequence) position: , mismatch: 7, identity: 0.781

ctttgatgataattttcttgcttctattacta	CRISPR spacer
cataggtgataattttcttggttttattaaaa	Protospacer
* * *.************** **.*****  *

66. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP019853 (Borreliella burgdorferi plasmid lp38, complete sequence) position: , mismatch: 7, identity: 0.781

ctttgatgataattttcttgcttctattacta	CRISPR spacer
cataggtgataattttcttggttttattaaaa	Protospacer
* * *.************** **.*****  *

67. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP019764 (Borreliella burgdorferi strain B31_NRZ isolate B31 plasmid p_lp38, complete sequence) position: , mismatch: 7, identity: 0.781

ctttgatgataattttcttgcttctattacta	CRISPR spacer
cataggtgataattttcttggttttattaaaa	Protospacer
* * *.************** **.*****  *

68. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017217 (Borreliella burgdorferi strain B331 plasmid B331_lp38, complete sequence) position: , mismatch: 7, identity: 0.781

ctttgatgataattttcttgcttctattacta	CRISPR spacer
cataggtgataattttcttggttttattaaaa	Protospacer
* * *.************** **.*****  *

69. spacer 3.13|941978|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 7, identity: 0.781

gtgatc--tgcgctgcttctgccactgtgcattc	CRISPR spacer
--ggtcgatgtgctgtttctgccactgtgcagcc	Protospacer
  *.**  **.****.*************** .*

70. spacer 3.13|941978|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 7, identity: 0.781

gtgatc--tgcgctgcttctgccactgtgcattc	CRISPR spacer
--ggtcgatgtgctgtttctgccactgtgcagcc	Protospacer
  *.**  **.****.*************** .*

71. spacer 3.14|942039|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to MN855819 (Bacteriophage sp. isolate 156, complete genome) position: , mismatch: 7, identity: 0.781

ttgtcgcaatcgctgctggtgagtggttcgtg	CRISPR spacer
tagaggcaatcgctggtggtgattggttcaag	Protospacer
* *  ********** ****** ******. *

72. spacer 4.8|951937|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to KX397365 (Erwinia phage vB_EamM_Caitlin, complete genome) position: , mismatch: 7, identity: 0.781

cattcgtct--tgccatctcttcgaccggcagca	CRISPR spacer
--ctcatccaatggcatctcttcaaccggcagca	Protospacer
  .**.**.  ** *********.**********

73. spacer 5.1|952340|32|NC_012214|CRISPRCasFinder matches to NZ_CP044357 (Acinetobacter baumannii strain CAM180-1 plasmid pCAM180A, complete sequence) position: , mismatch: 7, identity: 0.781

atagcgatatatattattgatagttaatgatt	CRISPR spacer
tgatctaaatataatattgatatttaatgatt	Protospacer
  * * * ***** ******** *********

74. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP050093 (Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b5, complete sequence) position: , mismatch: 7, identity: 0.781

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctacctcgccgaagt	Protospacer
. **************** * ******* . *

75. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP050082 (Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence) position: , mismatch: 7, identity: 0.781

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctacctcgccgaagt	Protospacer
. **************** * ******* . *

76. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NC_008384 (Rhizobium leguminosarum bv. viciae 3841 plasmid pRL11, complete sequence) position: , mismatch: 7, identity: 0.781

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctacctcgccgaagt	Protospacer
. **************** * ******* . *

77. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP049732 (Rhizobium leguminosarum strain A1 plasmid pRL11, complete sequence) position: , mismatch: 7, identity: 0.781

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctacctcgccgaagt	Protospacer
. **************** * ******* . *

78. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP013634 (Rhizobium sp. N324 plasmid pRspN324d, complete sequence) position: , mismatch: 7, identity: 0.781

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctacctcgccgaagt	Protospacer
. **************** * ******* . *

79. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NC_012858 (Rhizobium leguminosarum bv. trifolii WSM1325 plasmid pR132502, complete sequence) position: , mismatch: 7, identity: 0.781

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctatctcgccgaagt	Protospacer
. **************** * ******* . *

80. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NC_011366 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG202, complete sequence) position: , mismatch: 7, identity: 0.781

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctatctcgccgaagt	Protospacer
. **************** * ******* . *

81. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP054023 (Rhizobium sp. JKLM12A2 plasmid pPR12A202, complete sequence) position: , mismatch: 7, identity: 0.781

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctatctcgccgaagt	Protospacer
. **************** * ******* . *

82. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP054033 (Rhizobium sp. JKLM13E plasmid pPR13E02, complete sequence) position: , mismatch: 7, identity: 0.781

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctatctcgccgaagt	Protospacer
. **************** * ******* . *

83. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP053208 (Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1B, complete sequence) position: , mismatch: 7, identity: 0.781

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctacctcgccgaagt	Protospacer
. **************** * ******* . *

84. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NC_016907 (Gordonia polyisoprenivorans VH2 plasmid p174, complete sequence) position: , mismatch: 7, identity: 0.781

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
ctgtggctgccgctgctgatactcgccgtgat	Protospacer
..*  ************ * ********** *

85. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 7, identity: 0.781

---tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
aacccggc---gccgctgctcgaactcgacgtgca	Protospacer
   .****   **********.****** *****

86. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP025983 (Enterobacteriaceae bacterium A-F18 plasmid pAF18_1, complete sequence) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
agtttctagacagatttcggggggtttttgca	Protospacer
*. *. ...***********************

87. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP017586 (Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ05, complete sequence) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
agttcattgacagatttcagggggtttttgca	Protospacer
*. **.. .*********.*************

88. spacer 6.10|962199|32|NC_012214|CRT matches to NC_023025 (Cronobacter malonaticus plasmid p2, complete sequence) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
agtttctgtacagatttcagggggtttttgca	Protospacer
*. *. .* *********.*************

89. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP011050 (Cronobacter sakazakii strain ATCC 29544 plasmid CSK29544_3p, complete sequence) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
agtttctgtacagatttcagggggtttttgca	Protospacer
*. *. .* *********.*************

90. spacer 6.10|962199|32|NC_012214|CRT matches to NC_013285 (Cronobacter turicensis z3032 plasmid pCTU3, complete sequence) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
agtttctgtacagatttcagggggtttttgca	Protospacer
*. *. .* *********.*************

91. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP039454 (Enterobacter bugandensis strain 220 plasmid pSurvcare220, complete sequence) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aagatgatgacagatgtcggggggtttgtgca	Protospacer
*** .*  .****** *********** ****

92. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP017590 (Pantoea stewartii subsp. stewartii DC283 plasmid pDSJ09, complete sequence) position: , mismatch: 7, identity: 0.781

-aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
caaaacg-agacagatttcagggagtttttgca	Protospacer
 **. ** ..*********.***.*********

93. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP019840 (Enterobacter roggenkampii strain R11 plasmid pASM1, complete sequence) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aagatgatgacagatgtcggggggtttgtgca	Protospacer
*** .*  .****** *********** ****

94. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP022149 (Enterobacter roggenkampii strain 704SK10 plasmid p704SK10_1, complete sequence) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aagatgatgacagatgtcggggggtttgtgca	Protospacer
*** .*  .****** *********** ****

95. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP009855 (UNVERIFIED_ORG: Enterobacter cloacae strain ECNIH5 plasmid pENT-22e, complete sequence) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aagatgatgacagatgtcggggggtttgtgca	Protospacer
*** .*  .****** *********** ****

96. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP008907 (Enterobacter hormaechei subsp. hoffmannii ECR091 plasmid pENT-4bd, complete sequence) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aagatgatgacagatgtcggggggtttgtgca	Protospacer
*** .*  .****** *********** ****

97. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP033798 (Enterobacter roggenkampii strain FDAARGOS_523 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aagatgatgacagatgtcggggggtttgtgca	Protospacer
*** .*  .****** *********** ****

98. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP026851 (UNVERIFIED_ORG: Enterobacter cloacae strain AR_0072 plasmid unnamed1) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aagatgatgacagatgtcggggggtttgtgca	Protospacer
*** .*  .****** *********** ****

99. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP029719 (UNVERIFIED_ORG: Enterobacter cloacae strain AR_0154 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.781

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aagatgatgacagatgtcggggggtttgtgca	Protospacer
*** .*  .****** *********** ****

100. spacer 2.1|930412|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_048768 (Gordonia phage Chelms, complete genome) position: , mismatch: 8, identity: 0.75

cctcgcgtccgtgcggggctttgctatcatta	CRISPR spacer
cctcgcgtccgtgcgcggccttgttgtactcg	Protospacer
*************** ***.***.*.*  *..

101. spacer 2.1|930412|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to MT986029 (Gordonia phage Linetti, complete genome) position: , mismatch: 8, identity: 0.75

cctcgcgtccgtgcggggctttgctatcatta	CRISPR spacer
cctcgcgtccgtgcgcggccttgttgtactcg	Protospacer
*************** ***.***.*.*  *..

102. spacer 4.3|951637|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040754 (Sulfitobacter sp. BSw21498 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

gttccaggcttgccgcacatcaccagcccacc	CRISPR spacer
atggcctgcttgccgcacatcaccagaccagg	Protospacer
.*  *  ******************* ***

103. spacer 4.4|951697|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to LT615366 (Enterococcus phage VPE25 genome assembly, chromosome: VPE25) position: , mismatch: 8, identity: 0.75

--attgacgaaattttgacaacgctgaaactgcc	CRISPR spacer
tagttatc--aattttgaaaacggtgaaactgct	Protospacer
  .**. *  ******** **** *********.

104. spacer 4.4|951697|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to LT546029 (Enterococcus phage VFW genome assembly, chromosome: VFW) position: , mismatch: 8, identity: 0.75

-----attgacgaaattttgacaacgctgaaactgcc	CRISPR spacer
tagttatt-----aattttgaaaacggtgaaactgct	Protospacer
     ***     ******** **** *********.

105. spacer 4.4|951697|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to LT546030 (Enterococcus phage VPE25 genome assembly, chromosome: I) position: , mismatch: 8, identity: 0.75

--attgacgaaattttgacaacgctgaaactgcc	CRISPR spacer
tagttatc--aattttgaaaacggtgaaactgct	Protospacer
  .**. *  ******** **** *********.

106. spacer 4.4|951697|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to MT119361 (Enterococus phage vipetofem, complete genome) position: , mismatch: 8, identity: 0.75

--attgacgaaattttgacaacgctgaaactgcc	CRISPR spacer
tagttatc--aattttgaaaacggtgaaactgct	Protospacer
  .**. *  ******** **** *********.

107. spacer 4.5|951757|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029832 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.75

cccgttgtggctcaaagccggagatcagcacc-	CRISPR spacer
aacgttgtggctccatgccggagatc-gtatgg	Protospacer
  *********** * ********** *.*.

108. spacer 5.1|952340|32|NC_012214|CRISPRCasFinder matches to MN855600 (Bacteriophage sp. isolate 296, complete genome) position: , mismatch: 8, identity: 0.75

atagcgatatatattattgatagttaatgatt	CRISPR spacer
gtgcaaatatatattattgaaagttaattatg	Protospacer
.*.  .************** ******* **

109. spacer 5.1|952340|32|NC_012214|CRISPRCasFinder matches to NZ_CP014237 (Moraxella osloensis strain CCUG 350 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.75

atagcgatatatattattgatagttaatgatt	CRISPR spacer
aatttcatataaattattgatatttaatgaat	Protospacer
*   . ***** ********** ******* *

110. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP050105 (Rhizobium leguminosarum bv. trifolii strain 4B plasmid pRL4b6, complete sequence) position: , mismatch: 8, identity: 0.75

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgagcgctgccgctgctctatctcgccgaagt	Protospacer
. .*************** * ******* . *

111. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP025508 (Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvB, complete sequence) position: , mismatch: 8, identity: 0.75

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgagcgctgccgctgctctatctcgccgaagt	Protospacer
. .*************** * ******* . *

112. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP050110 (Rhizobium leguminosarum bv. trifolii strain 3B plasmid pRL3b4, complete sequence) position: , mismatch: 8, identity: 0.75

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgagcgctgccgctgctctatctcgccgaagt	Protospacer
. .*************** * ******* . *

113. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP030764 (Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed4, complete sequence) position: , mismatch: 8, identity: 0.75

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgagcgctgccgctgctctatctcgccgaagt	Protospacer
. .*************** * ******* . *

114. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP022667 (Rhizobium leguminosarum bv. viciae strain BIHB 1217 plasmid pPR2, complete sequence) position: , mismatch: 8, identity: 0.75

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgagcgctgccgctgctctatctcgccgaagt	Protospacer
. .*************** * ******* . *

115. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP050087 (Rhizobium leguminosarum bv. trifolii strain 23B plasmid pRL23b5, complete sequence) position: , mismatch: 8, identity: 0.75

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgagcgctgccgctgctctatctcgccgaagt	Protospacer
. .*************** * ******* . *

116. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NC_021289 (Burkholderia insecticola plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.75

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
tcggcgctgccgctgcgcaagctcacgtcacg	Protospacer
**************** ***.***.*  ..*

117. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP054029 (Rhizobium sp. JKLM19E plasmid pPR19E02, complete sequence) position: , mismatch: 8, identity: 0.75

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cgggcgctgccgctgctctacctcgcggaagt	Protospacer
. **************** * ***** * . *

118. spacer 6.3|962079|32|NC_012214|PILER-CR,CRT matches to NC_015163 (Deinococcus proteolyticus MRP plasmid pDEIPR04, complete sequence) position: , mismatch: 8, identity: 0.75

agtcccggcaccacctcagcgcccagccctgt	CRISPR spacer
ggctgcggcaccacctcagcgccctggcccgc	Protospacer
.*.. ******************* * **.*.

119. spacer 6.3|962079|32|NC_012214|PILER-CR,CRT matches to NC_015162 (Deinococcus proteolyticus MRP plasmid pDEIPR02, complete sequence) position: , mismatch: 8, identity: 0.75

agtcccggcaccacctcagcgcccagccctgt	CRISPR spacer
ggctgcggcaccacctcagcgccctgacccgc	Protospacer
.*.. ******************* * **.*.

120. spacer 6.10|962199|32|NC_012214|CRT matches to NC_016515 (Enterobacter ludwigii strain EcWSU1 plasmid pEcWSU1_A, complete sequence) position: , mismatch: 8, identity: 0.75

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aaagtggatacagatttcagggggtttgtgca	Protospacer
**. .* . *********.******** ****

121. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP033799 (Enterobacter roggenkampii strain FDAARGOS_523 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.75

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aaagtggatacagatttcagggggtttgtgca	Protospacer
**. .* . *********.******** ****

122. spacer 6.10|962199|32|NC_012214|CRT matches to NZ_CP022534 (Enterobacter hormaechei strain MS7884A plasmid pMS7884B, complete sequence) position: , mismatch: 8, identity: 0.75

aagtcgcgaacagatttcggggggtttttgca	CRISPR spacer
aaagtggatacagatttcagggggtttgtgca	Protospacer
**. .* . *********.******** ****

123. spacer 2.2|930473|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to MT774378 (CrAssphage cr106_1, complete genome) position: , mismatch: 9, identity: 0.719

tttatgacgctgattattatcaggctaaccat	CRISPR spacer
agttggaagctgattattatcaggttaaatct	Protospacer
  *  ** ****************.*** . *

124. spacer 2.7|930779|32|NC_012214|CRISPRCasFinder,CRT matches to NZ_CP045959 (Salmonella enterica subsp. enterica serovar Birkenhead strain AUSMDU00010532 plasmid pAUSMDU00010532_01, complete sequence) position: , mismatch: 9, identity: 0.719

ccgtgttgaagccattggtgttacctctattt	CRISPR spacer
tggtcttgaagccattggtgtgacctgtcagc	Protospacer
. ** **************** **** *   .

125. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP044456 (Acinetobacter indicus strain B18 plasmid pB18-1, complete sequence) position: , mismatch: 9, identity: 0.719

ctttgatgataattttcttgcttctattacta	CRISPR spacer
ctttgatcatagttttcttgcttaaagccttt	Protospacer
******* ***.***********  * . .*

126. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP039144 (Acinetobacter sp. 10FS3-1 plasmid p10FS3-1-1, complete sequence) position: , mismatch: 9, identity: 0.719

ctttgatgataattttcttgcttctattacta	CRISPR spacer
ctttgatcatagttttcttgcttaaagccttt	Protospacer
******* ***.***********  * . .*

127. spacer 3.4|941428|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045341 (Vibrio sp. THAF190c plasmid pTHAF190c_c, complete sequence) position: , mismatch: 9, identity: 0.719

aaagtttggcagatgcgctacaagattgaagg	CRISPR spacer
aattgttggcagatgcgttacaaaattggcta	Protospacer
**   ************.*****.****.  .

128. spacer 3.10|941795|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_011143 (Phenylobacterium zucineum HLK1 plasmid, complete sequence) position: , mismatch: 9, identity: 0.719

catggccacccggccaaccacgatccagttat	CRISPR spacer
catggccaccaggccgaccacgagcacaaggt	Protospacer
********** ****.******* *  .  .*

129. spacer 4.5|951757|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_005241 (Cupriavidus necator H16 megaplasmid pHG1, complete sequence) position: , mismatch: 9, identity: 0.719

cccgttgtggctcaaagccggagatcagcacc	CRISPR spacer
gccgctgtggctcaaggccggagactgggtcg	Protospacer
 ***.**********.********...*  *

130. spacer 4.5|951757|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039289 (Cupriavidus necator H16 plasmid pHG1, complete sequence) position: , mismatch: 9, identity: 0.719

cccgttgtggctcaaagccggagatcagcacc	CRISPR spacer
gccgctgtggctcaaggccggagactgggtcg	Protospacer
 ***.**********.********...*  *

131. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 9, identity: 0.719

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
acgttctggccgctgctcatgctcgccgtgca	Protospacer
 ** . . *********** .**********

132. spacer 6.2|962019|32|NC_012214|PILER-CR,CRT matches to NZ_CP022416 (Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-1, complete sequence) position: , mismatch: 9, identity: 0.719

accatcactgacagcgaagcccggaataaacc	CRISPR spacer
accatcgctgacagcgaagcgcggcccgtagt	Protospacer
******.************* ***  .. * .

133. spacer 6.3|962079|32|NC_012214|PILER-CR,CRT matches to MH727545 (Mycobacterium phage DismalStressor, complete genome) position: , mismatch: 9, identity: 0.719

agtcccggcaccacctcagcgcccagccctgt	CRISPR spacer
cgccccggcgccaccgcagcgcccagcggatg	Protospacer
 *.******.***** ***********

134. spacer 6.3|962079|32|NC_012214|PILER-CR,CRT matches to NC_026598 (Mycobacterium phage Milly, complete genome) position: , mismatch: 9, identity: 0.719

agtcccggcaccacctcagcgcccagccctgt	CRISPR spacer
cgccccggcgccaccgcagcgcccagcggatg	Protospacer
 *.******.***** ***********

135. spacer 6.3|962079|32|NC_012214|PILER-CR,CRT matches to MH834601 (Mycobacterium phage BoostSeason, complete genome) position: , mismatch: 9, identity: 0.719

agtcccggcaccacctcagcgcccagccctgt	CRISPR spacer
cgccccggcgccaccgcagcgcccagcggatg	Protospacer
 *.******.***** ***********

136. spacer 6.3|962079|32|NC_012214|PILER-CR,CRT matches to KX688047 (Mycobacterium phage Marcoliusprime, complete genome) position: , mismatch: 9, identity: 0.719

agtcccggcaccacctcagcgcccagccctgt	CRISPR spacer
cgccccggcgccaccgcagcgcccagcggatg	Protospacer
 *.******.***** ***********

137. spacer 6.3|962079|32|NC_012214|PILER-CR,CRT matches to NC_028759 (Mycobacterium phage Mufasa, complete genome) position: , mismatch: 9, identity: 0.719

agtcccggcaccacctcagcgcccagccctgt	CRISPR spacer
cgccccggcgccaccgcagcgcccagcggatg	Protospacer
 *.******.***** ***********

138. spacer 6.3|962079|32|NC_012214|PILER-CR,CRT matches to MF140408 (Mycobacterium phage DismalFunk, complete genome) position: , mismatch: 9, identity: 0.719

agtcccggcaccacctcagcgcccagccctgt	CRISPR spacer
cgccccggcgccaccgcagcgcccagcggatg	Protospacer
 *.******.***** ***********

139. spacer 6.3|962079|32|NC_012214|PILER-CR,CRT matches to MF140411 (Mycobacterium phage Findley, complete genome) position: , mismatch: 9, identity: 0.719

agtcccggcaccacctcagcgcccagccctgt	CRISPR spacer
cgccccggcgccaccgcagcgcccagcggatg	Protospacer
 *.******.***** ***********

140. spacer 6.3|962079|32|NC_012214|PILER-CR,CRT matches to NZ_CP031159 (Deinococcus wulumuqiensis strain NEB 479 plasmid pDrdA, complete sequence) position: , mismatch: 9, identity: 0.719

agtcccggcaccacctcagcgcccagccctgt	CRISPR spacer
cagacggccaccaccacagcgcccggccctgc	Protospacer
 .  * * ******* ********.******.

141. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NZ_CP018230 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.75

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagtcgggcgctgccgctgctctacctcgccgaggt	Protospacer
 *. . **************** * ******* * *

142. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NZ_CP016289 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.75

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagtcgggcgctgccgctgctctacctcgccgaggt	Protospacer
 *. . **************** * ******* * *

143. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NZ_CP022566 (Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK02, complete sequence) position: , mismatch: 9, identity: 0.75

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctacctcgccgaggt	Protospacer
 *. . **************** * ******* * *

144. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NZ_CP050099 (Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence) position: , mismatch: 9, identity: 0.75

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctatctcgccgaggt	Protospacer
 *. . **************** * ******* * *

145. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NZ_CP053441 (Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence) position: , mismatch: 9, identity: 0.75

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctacctcgccgaggt	Protospacer
 *. . **************** * ******* * *

146. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP021931 (Lactobacillus plantarum strain TMW 1.1308 plasmid pL11308-1, complete sequence) position: , mismatch: 10, identity: 0.688

ctttgatgataattttcttgcttctattacta	CRISPR spacer
gcgttatgataattttcttgcgtcaatttgat	Protospacer
 . * **************** ** ***

147. spacer 2.10|930962|32|NC_012214|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP050806 (Lactobacillus plantarum strain SPC-SNU 72-2 plasmid pLBP752, complete sequence) position: , mismatch: 10, identity: 0.688

ctttgatgataattttcttgcttctattacta	CRISPR spacer
gcgttatgataattttcttgcgtcaatttgat	Protospacer
 . * **************** ** ***

148. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024444 (Moraxella osloensis strain NP7 plasmid pNP7-1, complete sequence) position: , mismatch: 10, identity: 0.688

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
ttttaatgcctttgtcgatgcacttttgaagc	Protospacer
 .************.*******.***.    .

149. spacer 3.2|941306|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040258 (Moraxella osloensis strain MOXF1 plasmid pMOXF1, complete sequence) position: , mismatch: 10, identity: 0.688

gcttaatgcctttgccgatgcattttcctttt	CRISPR spacer
ttttaatgcctttgtcgatgcacttttgaagc	Protospacer
 .************.*******.***.    .

150. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to CP051632 (Escherichia coli O121 strain FDA858783-1-52 plasmid pFNW19M81, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

151. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028113 (Escherichia coli O103 str. RM8385 plasmid pRM8385-1, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

152. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031911 (Escherichia coli O121:H19 strain FWSEC0006 plasmid unnamed15, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

153. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031923 (Escherichia coli O26:H11 strain FWSEC0001 plasmid unnamed6, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

154. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027220 (Escherichia coli strain 2015C-3163 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

155. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027578 (Escherichia coli strain 2013C-4225 plasmid unnamed) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

156. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027350 (Escherichia coli strain 2014C-3655 plasmid unnamed) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

157. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP037944 (Escherichia coli strain CFSAN027343 plasmid pCFSAN027343, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

158. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027547 (Escherichia coli strain 2013C-4187 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

159. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027391 (Escherichia coli strain 2015C-4944 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

160. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_012487 (Escherichia coli plasmid pO26-Vir, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

161. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027444 (Escherichia coli strain 2013C-3252 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

162. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027473 (Escherichia coli strain 2014C-3050 plasmid unnamed) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

163. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_013728 (Escherichia coli O26:H- plasmid pO26-CRL, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

164. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027601 (Escherichia coli strain 97-3250 plasmid unnamed2) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

165. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027436 (Escherichia coli strain 2014C-3599 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

166. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006028 (Escherichia coli O145:H28 str. RM13514 plasmid pO145-13514, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

167. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to AP019709 (Escherichia coli O145:H28 122715 plasmid pO145_122715_1 DNA, complete genome) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

168. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027456 (Escherichia coli strain 2014C-4423 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

169. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018810 (Escherichia coli strain E2865 plasmid pE2865-2, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

170. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP037946 (Escherichia coli strain CFSAN027346 plasmid pCFSAN027346-1, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

171. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to AP019707 (Escherichia coli O145:H28 112648 plasmid pO145_112648_1 DNA, complete genome) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

172. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027764 (Escherichia coli strain 2015C-3125 plasmid unnamed1) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

173. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027339 (Escherichia coli strain 2014C-3051 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

174. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027556 (Escherichia coli strain 2013C-3513 plasmid unnamed2) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

175. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027386 (Escherichia coli strain 2014C-3057 plasmid unnamed) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

176. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027354 (Escherichia coli strain 2012C-4606 plasmid unnamed2) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

177. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027583 (Escherichia coli strain 2013C-4538 plasmid unnamed) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

178. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027318 (Escherichia coli strain 2015C-3107 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

179. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_013369 (Escherichia coli O26:H11 str. 11368 plasmid pO26_1, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

180. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to AP019704 (Escherichia coli O145:H28 10942 plasmid pO145_10942_1 DNA, complete genome) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

181. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022408 (Escherichia coli O121:H19 strain 16-9255 plasmid punamed1, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

182. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028115 (Escherichia coli O26 str. RM8426 plasmid pRM8426, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

183. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028380 (Escherichia coli O145 str. RM9872 plasmid pRM9872-1, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

184. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to CP027321 (Escherichia coli strain 2014C-3084 plasmid unnamed2) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

185. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to CP027359 (Escherichia coli strain 2014C-4639 plasmid unnamed1) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

186. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031920 (Escherichia coli O145:NM strain FWSEC0002 plasmid unnamed9, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

187. spacer 4.2|951577|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028111 (Escherichia coli O121 str. RM8352 plasmid pRM8352, complete sequence) position: , mismatch: 10, identity: 0.688

tgccggacagcgtgatgattttcaataaacca	CRISPR spacer
ttgaacacagcctgatgtttttcaataaagac	Protospacer
*   . ***** ***** ***********

188. spacer 4.3|951637|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011248 (Agrobacterium tumefaciens strain Ach5 plasmid pAt, complete sequence) position: , mismatch: 10, identity: 0.688

gttccaggcttgccgcacatcaccagcccacc	CRISPR spacer
ctgagagccttgccgcagatcaccagccgtgg	Protospacer
 *   ** ********* **********

189. spacer 4.3|951637|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032919 (Agrobacterium tumefaciens strain 15955 plasmid pAt15955, complete sequence) position: , mismatch: 10, identity: 0.688

gttccaggcttgccgcacatcaccagcccacc	CRISPR spacer
ctgagagccttgccgcagatcaccagccgtgg	Protospacer
 *   ** ********* **********

190. spacer 4.3|951637|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033029 (Agrobacterium tumefaciens strain A6 plasmid pAtA6, complete sequence) position: , mismatch: 10, identity: 0.688

gttccaggcttgccgcacatcaccagcccacc	CRISPR spacer
ctgagagccttgccgcagatcaccagccgtgg	Protospacer
 *   ** ********* **********

191. spacer 4.5|951757|32|NC_012214|PILER-CR,CRISPRCasFinder,CRT matches to NC_017273 (Thermus thermophilus SG0.5JP17-16 plasmid pTHTHE1601, complete sequence) position: , mismatch: 10, identity: 0.688

cccgttgtggctcaaagccggagatcagcacc	CRISPR spacer
ggtccaaaggctcaaagccggagatcactacc	Protospacer
  . . . ******************* .***

192. spacer 6.1|961959|32|NC_012214|PILER-CR,CRT matches to NC_016108 (Methylomicrobium alcaliphilum 20Z plasmid MEALZ_p, complete sequence) position: , mismatch: 10, identity: 0.688

tcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
gaacagctatcgctgctcaaactcgccgtcta	Protospacer
  .  ***..******************* .

193. spacer 6.3|962079|32|NC_012214|PILER-CR,CRT matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 10, identity: 0.688

agtcccggcaccacctcagcgcccagccctgt	CRISPR spacer
gtcaccggcaccacctcggcgcccagcagccg	Protospacer
. . *************.*********  .

194. spacer 6.3|962079|32|NC_012214|PILER-CR,CRT matches to NZ_CP043439 (Cupriavidus campinensis strain MJ1 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.688

agtcccggcaccacctcagcgcccagccctgt	CRISPR spacer
tctgccggcaccacctcaccgcacagcagatc	Protospacer
  * ************** *** ****    .

195. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NC_012858 (Rhizobium leguminosarum bv. trifolii WSM1325 plasmid pR132502, complete sequence) position: , mismatch: 10, identity: 0.722

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctatctcgccgaagt	Protospacer
 *. . **************** * ******* . *

196. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NC_011366 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG202, complete sequence) position: , mismatch: 10, identity: 0.722

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctatctcgccgaagt	Protospacer
 *. . **************** * ******* . *

197. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NZ_CP050093 (Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b5, complete sequence) position: , mismatch: 10, identity: 0.722

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctacctcgccgaagt	Protospacer
 *. . **************** * ******* . *

198. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NZ_CP050082 (Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence) position: , mismatch: 10, identity: 0.722

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctacctcgccgaagt	Protospacer
 *. . **************** * ******* . *

199. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NC_008384 (Rhizobium leguminosarum bv. viciae 3841 plasmid pRL11, complete sequence) position: , mismatch: 10, identity: 0.722

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctacctcgccgaagt	Protospacer
 *. . **************** * ******* . *

200. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NZ_CP049732 (Rhizobium leguminosarum strain A1 plasmid pRL11, complete sequence) position: , mismatch: 10, identity: 0.722

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctacctcgccgaagt	Protospacer
 *. . **************** * ******* . *

201. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NZ_CP013634 (Rhizobium sp. N324 plasmid pRspN324d, complete sequence) position: , mismatch: 10, identity: 0.722

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctacctcgccgaagt	Protospacer
 *. . **************** * ******* . *

202. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NZ_CP054023 (Rhizobium sp. JKLM12A2 plasmid pPR12A202, complete sequence) position: , mismatch: 10, identity: 0.722

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctatctcgccgaagt	Protospacer
 *. . **************** * ******* . *

203. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NZ_CP054033 (Rhizobium sp. JKLM13E plasmid pPR13E02, complete sequence) position: , mismatch: 10, identity: 0.722

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctatctcgccgaagt	Protospacer
 *. . **************** * ******* . *

204. spacer 6.5|961955|36|NC_012214|CRISPRCasFinder matches to NZ_CP053208 (Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1B, complete sequence) position: , mismatch: 10, identity: 0.722

gaaatcggcgctgccgctgctcaaactcgccgtgct	CRISPR spacer
cagccgggcgctgccgctgctctacctcgccgaagt	Protospacer
 *. . **************** * ******* . *

205. spacer 6.6|962015|36|NC_012214|CRISPRCasFinder matches to NZ_CP022416 (Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-1, complete sequence) position: , mismatch: 11, identity: 0.694

gaaaaccatcactgacagcgaagcccggaataaacc	CRISPR spacer
agaaaccatcgctgacagcgaagcgcggcccgtagt	Protospacer
..********.************* ***  .. * .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

685462 : 736894

Salmonella_phage(75.0%)

plate,lysis,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012666951.1\|685462_688708_+	DEAD/DEAH box helicase	A0A1B1ISM1	uncultured_Mediterranean_phage	1.3e-30	25.6
WP_012666952.1\|689251_689866_-	phage repressor protein CI	A0A1S6KZZ7	Salmonella_phage	6.8e-34	42.1
WP_012666953.1\|690595_690787_+	hypothetical protein	A0A1S6L006	Salmonella_phage	9.5e-19	82.5
WP_104945024.1\|690922_692058_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	6.9e-80	55.8
WP_104945199.1\|692639_692855_+	hypothetical protein	E5G6N0	Salmonella_phage	3.9e-21	69.0
WP_012666956.1\|692835_693345_+	lysozyme	E5G6N1	Salmonella_phage	3.0e-67	71.4
WP_012666957.1\|693341_693764_+\|lysis	LysB family phage lysis regulatory protein	A0A1S6KZX8	Salmonella_phage	5.5e-43	68.6
WP_012666958.1\|694787_695315_-	phospholipase D family protein	NA	NA	NA	NA
WP_014538548.1\|696802_697018_+	Late control gene B protein (GpB)	E5G6Q4	Salmonella_phage	2.0e-20	74.6
WP_012666960.1\|697768_698215_-	hypothetical protein	NA	NA	NA	NA
WP_012666961.1\|698857_700252_+	MHS family MFS transporter	NA	NA	NA	NA
WP_012666962.1\|700333_701350_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_012666963.1\|701364_702351_+	nucleoside hydrolase	NA	NA	NA	NA
WP_012666964.1\|702402_703821_-	PepSY domain-containing protein	NA	NA	NA	NA
WP_012666965.1\|703891_704332_-	DUF2946 domain-containing protein	NA	NA	NA	NA
WP_162013506.1\|704374_704512_-	hypothetical protein	NA	NA	NA	NA
WP_157861010.1\|704641_704884_-	hypothetical protein	NA	NA	NA	NA
WP_012666967.1\|705141_706347_+	MFS transporter	NA	NA	NA	NA
WP_012666968.1\|706512_707610_-	GGDEF domain-containing protein	NA	NA	NA	NA
WP_012666969.1\|707855_708089_+	DUF1435 domain-containing protein	NA	NA	NA	NA
WP_012666970.1\|708576_709605_-	16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC	NA	NA	NA	NA
WP_041474086.1\|709774_710197_+	DNA polymerase III subunit psi	NA	NA	NA	NA
WP_012666972.1\|710159_710600_+	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_012666973.1\|710614_711295_+	pyrimidine 5'-nucleotidase	NA	NA	NA	NA
WP_081441620.1\|712274_712778_+	hypothetical protein	NA	NA	NA	NA
WP_012666975.1\|712802_713315_+	type VI secretion system lipoprotein TssJ	NA	NA	NA	NA
WP_012666976.1\|713334_714678_+\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_012666977.1\|714695_715937_+	DotU family type VI secretion system protein	NA	NA	NA	NA
WP_012666978.1\|715940_719573_+	type VI secretion system membrane subunit TssM	NA	NA	NA	NA
WP_012666979.1\|719589_720300_+	type VI secretion system-associated protein TagF	NA	NA	NA	NA
WP_012666980.1\|720317_721325_+	type VI secretion system protein TssA	NA	NA	NA	NA
WP_012666981.1\|721387_721924_+	type VI secretion system contractile sheath small subunit	NA	NA	NA	NA
WP_012666982.1\|721927_723427_+	type VI secretion system contractile sheath large subunit	NA	NA	NA	NA
WP_012666983.1\|723423_723699_+	hypothetical protein	NA	NA	NA	NA
WP_012666984.1\|723970_724453_+	type VI secretion system tube protein Hcp	NA	NA	NA	NA
WP_012666985.1\|724507_724951_+	hypothetical protein	NA	NA	NA	NA
WP_012666986.1\|724975_725713_+	hypothetical protein	NA	NA	NA	NA
WP_071819841.1\|725781_726174_+	DUF1311 domain-containing protein	NA	NA	NA	NA
WP_104945142.1\|726476_727127_+	hypothetical protein	NA	NA	NA	NA
WP_148217847.1\|727762_727993_+	hypothetical protein	NA	NA	NA	NA
WP_012666988.1\|728202_728604_+	DUF1311 domain-containing protein	NA	NA	NA	NA
WP_012666989.1\|728954_730775_+	type VI secretion system-associated FHA domain protein TagH	NA	NA	NA	NA
WP_012666990.1\|730771_731566_+	serine/threonine-protein phosphatase	NA	NA	NA	NA
WP_012666991.1\|731583_732552_+	hypothetical protein	NA	NA	NA	NA
WP_012666992.1\|732561_733383_+	hypothetical protein	NA	NA	NA	NA
WP_012666993.1\|733379_733946_+\|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA
WP_012666994.1\|733964_735839_+\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_012666995.1\|735835_736894_+\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA

DBSCAN-SWA_2

1606878 : 1613809

Tupanvirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012667718.1\|1606878_1607775_+	UTP--glucose-1-phosphate uridylyltransferase GalF	A0A127AW70	Bacillus_phage	6.2e-44	40.3
WP_012667719.1\|1607829_1608843_+	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	4.1e-76	45.0
WP_012667720.1\|1609236_1610307_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	1.3e-99	54.4
WP_012667721.1\|1610308_1611175_+	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	1.3e-107	66.7
WP_012667722.1\|1611293_1612229_+	NAD-dependent epimerase/dehydratase family protein	A0A2K9L5H6	Tupanvirus	5.6e-19	25.5
WP_012667723.1\|1612301_1613069_+	ABC transporter permease	NA	NA	NA	NA
WP_012667724.1\|1613068_1613809_+	ABC transporter ATP-binding protein	A0A2K9L3Z8	Tupanvirus	3.7e-10	30.2

DBSCAN-SWA_3

1978495 : 2005154

Pseudoalteromonas_phage(15.0%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012668049.1\|1978495_1980739_-	hypothetical protein	H9C157	Pectobacterium_phage	1.2e-112	35.3
WP_012668050.1\|1980740_1980995_-	hypothetical protein	NA	NA	NA	NA
WP_012668051.1\|1981077_1981353_-	hypothetical protein	NA	NA	NA	NA
WP_012668053.1\|1982147_1982549_-	helix-turn-helix domain-containing protein	K7PM82	Enterobacteria_phage	3.3e-13	50.0
WP_012668054.1\|1982632_1982836_+	hypothetical protein	NA	NA	NA	NA
WP_012668055.1\|1982832_1983300_+	hypothetical protein	NA	NA	NA	NA
WP_012668056.1\|1983296_1984205_+	hypothetical protein	A0A248SL49	Klebsiella_phage	1.3e-52	40.1
WP_104945197.1\|1984155_1984953_+	hypothetical protein	NA	NA	NA	NA
WP_012668058.1\|1984954_1985197_+	hypothetical protein	A0A1V0E8D1	Vibrio_phage	3.3e-16	58.4
WP_071819811.1\|1985377_1985533_+	Hok/Gef family protein	NA	NA	NA	NA
WP_012668060.1\|1985880_1986078_+	hypothetical protein	NA	NA	NA	NA
WP_012668061.1\|1986135_1986735_+	DUF1367 family protein	A0A0U2RT94	Escherichia_phage	5.2e-79	71.4
WP_012668062.1\|1986731_1987211_+	DUF1364 family protein	E5AGG0	Erwinia_phage	4.8e-35	74.5
WP_012668063.1\|1987210_1987897_+	antitermination protein	I6PDF8	Cronobacter_phage	3.8e-25	36.0
WP_012668064.1\|1988068_1988404_+\|holin	phage holin, lambda family	Q2A0C6	Sodalis_phage	1.2e-16	43.3
WP_012668065.1\|1988407_1989031_+	glycoside hydrolase family 19 protein	F1C591	Cronobacter_phage	2.1e-67	60.4
WP_012668066.1\|1989027_1989435_+	DUF2570 family protein	NA	NA	NA	NA
WP_012668068.1\|1990233_1990578_+	hypothetical protein	NA	NA	NA	NA
WP_014538898.1\|1990574_1991015_+	DUF4054 domain-containing protein	NA	NA	NA	NA
WP_012668070.1\|1991011_1991470_+	hypothetical protein	A0A2H5BG34	Pseudoalteromonas_phage	1.9e-12	30.9
WP_012668071.1\|1991469_1991838_+	hypothetical protein	NA	NA	NA	NA
WP_012668072.1\|1991827_1992343_+	hypothetical protein	NA	NA	NA	NA
WP_012668073.1\|1992357_1993845_+	DUF3383 domain-containing protein	A0A088C3U1	Shewanella_sp._phage	9.9e-79	36.1
WP_012668074.1\|1993855_1994308_+	hypothetical protein	A1Z014	Burkholderia_virus	2.5e-25	44.1
WP_012668075.1\|1994349_1994808_+	hypothetical protein	NA	NA	NA	NA
WP_012668076.1\|1994890_1996567_+	hypothetical protein	A0A2H5BG44	Pseudoalteromonas_phage	1.1e-20	28.9
WP_012668077.1\|1996563_1997073_+	hypothetical protein	NA	NA	NA	NA
WP_012668078.1\|1997079_1997373_+	hypothetical protein	NA	NA	NA	NA
WP_012668079.1\|1997365_1998181_+	hypothetical protein	Q6IWQ0	Burkholderia_phage	1.7e-43	37.7
WP_012668080.1\|1998184_1998877_+	hypothetical protein	A0A2H4P6V3	Pseudomonas_phage	6.3e-28	35.3
WP_012668081.1\|1998873_1999218_+	hypothetical protein	NA	NA	NA	NA
WP_012668082.1\|1999210_2000398_+	hypothetical protein	A0A2H5BG53	Pseudoalteromonas_phage	2.6e-74	38.7
WP_012668083.1\|2000394_2001048_+	DUF2612 domain-containing protein	Q6IWQ4	Burkholderia_phage	2.3e-35	40.5
WP_012668084.1\|2001051_2001987_+	phage related-protein	A0A0F6R6B6	Escherichia_coli_O157_typing_phage	1.7e-28	44.5
WP_012668085.1\|2002007_2003123_-	acyltransferase	A0A2H4JA46	uncultured_Caudovirales_phage	1.4e-32	31.8
WP_012668087.1\|2003831_2004677_-	acyltransferase	NA	NA	NA	NA
WP_071819813.1\|2004610_2004844_-	acyltransferase family protein	NA	NA	NA	NA
WP_012668088.1\|2004893_2005154_-	HicB family protein	Q775F5	Haemophilus_virus	1.8e-15	35.6

DBSCAN-SWA_4

2224639 : 2330244

114

Salmonella_phage(22.22%)

portal,terminase,tail,head,lysis,holin,transposase,integrase,plate,protease,tRNA,capsid

attL 2270771:2270785|attR 2327632:2327646

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012668273.1\|2224639_2225227_+\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_041474114.1\|2225261_2225942_-	EAL domain-containing protein	NA	NA	NA	NA
WP_012668275.1\|2226076_2227558_-	SulP family inorganic anion transporter	A0A2H4J153	uncultured_Caudovirales_phage	1.9e-90	39.6
WP_012668276.1\|2227916_2229008_+	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_012668277.1\|2229360_2233515_-	hypothetical protein	NA	NA	NA	NA
WP_012668279.1\|2234346_2235552_-	hypothetical protein	NA	NA	NA	NA
WP_012668280.1\|2235821_2236973_-	IpaD/SipD/SspD family type III secretion system needle tip protein	NA	NA	NA	NA
WP_012668281.1\|2237038_2238040_-	hypothetical protein	NA	NA	NA	NA
WP_012668282.1\|2238080_2239982_-	type III secretion system translocon subunit SctE	NA	NA	NA	NA
WP_012668283.1\|2239978_2240536_-	SycD/LcrH family type III secretion system chaperone	NA	NA	NA	NA
WP_012668284.1\|2240690_2241782_-	EscU/YscU/HrcU family type III secretion system export apparatus switch protein	NA	NA	NA	NA
WP_012668285.1\|2241795_2242566_-	type III secretion system export apparatus subunit SctT	NA	NA	NA	NA
WP_012668286.1\|2242578_2242833_-	type III secretion system export apparatus subunit SctS	NA	NA	NA	NA
WP_012668287.1\|2242829_2243501_-	EscR/YscR/HrcR family type III secretion system export apparatus protein	NA	NA	NA	NA
WP_012668288.1\|2243490_2244417_-	hypothetical protein	NA	NA	NA	NA
WP_041474003.1\|2244413_2245259_-	type III secretion system protein	NA	NA	NA	NA
WP_041474004.1\|2245239_2245710_-	hypothetical protein	NA	NA	NA	NA
WP_012668291.1\|2245684_2246980_-	FliI/YscN family ATPase	NA	NA	NA	NA
WP_012668292.1\|2246996_2247404_-	hypothetical protein	NA	NA	NA	NA
WP_012668293.1\|2247393_2249469_-	EscV/YscV/HrcV family type III secretion system export apparatus protein	NA	NA	NA	NA
WP_012668294.1\|2249510_2250626_-	invasion protein	NA	NA	NA	NA
WP_012668295.1\|2250638_2252405_-	EscC/YscC/HrcC family type III secretion system outer membrane ring protein	NA	NA	NA	NA
WP_012668296.1\|2252397_2253264_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012668297.1\|2253622_2254909_+	type III secretion system protein	NA	NA	NA	NA
WP_014539007.1\|2254886_2255159_+	type III secretion system needle filament subunit SctF	NA	NA	NA	NA
WP_012668299.1\|2255202_2255526_+	type III secretion system inner rod subunit SctI	NA	NA	NA	NA
WP_012668300.1\|2255525_2256287_+	type III secretion inner membrane ring lipoprotein SctJ	NA	NA	NA	NA
WP_012668301.1\|2256291_2256846_+	oxidoreductase	NA	NA	NA	NA
WP_012668302.1\|2256826_2257516_+	hypothetical protein	NA	NA	NA	NA
WP_012668303.1\|2257502_2257868_+	hypothetical protein	NA	NA	NA	NA
WP_049779061.1\|2258197_2258830_-	transcriptional regulator	NA	NA	NA	NA
WP_012668305.1\|2260192_2260438_+	hypothetical protein	NA	NA	NA	NA
WP_104944977.1\|2261072_2262223_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	1.1e-48	40.4
WP_012668307.1\|2262724_2262958_+	YgdI/YgdR family lipoprotein	NA	NA	NA	NA
WP_012668308.1\|2262973_2263204_+	YgdI/YgdR family lipoprotein	NA	NA	NA	NA
WP_012668309.1\|2263561_2265202_+	two-component system sensor histidine kinase DcuS	NA	NA	NA	NA
WP_012668310.1\|2265198_2265918_+	two-component system response regulator DcuR	NA	NA	NA	NA
WP_012668311.1\|2265898_2266867_-	FAD:protein FMN transferase	NA	NA	NA	NA
WP_012668312.1\|2266940_2269718_-	flavocytochrome c	A0A2P0ZL82	Lactobacillus_phage	1.8e-65	30.9
WP_012668313.1\|2270295_2271807_+	DASS family sodium-coupled anion symporter	NA	NA	NA	NA
2270771:2270785	attL	NA	NA	NA	NA
WP_012668314.1\|2271988_2273635_+	fumarate hydratase	NA	NA	NA	NA
WP_012668315.1\|2274064_2274328_+	hypothetical protein	NA	NA	NA	NA
WP_012668316.1\|2274464_2275394_+	N-acetyl-gamma-glutamyl-phosphate reductase	NA	NA	NA	NA
WP_012668317.1\|2275676_2277353_+	alpha,alpha-trehalase TreA	NA	NA	NA	NA
WP_012668318.1\|2277439_2277688_-	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
WP_012668319.1\|2278346_2278982_-	membrane-bound lytic murein transglycosylase EmtA	NA	NA	NA	NA
WP_012668320.1\|2279176_2280121_+	muramoyltetrapeptide carboxypeptidase	NA	NA	NA	NA
WP_012668321.1\|2280117_2280792_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_012668322.1\|2281093_2281339_+	DinI family protein	K7PKR6	Enterobacteria_phage	2.5e-24	68.8
WP_014544100.1\|2281838_2282129_-\|holin	phage holin family protein	K7PKN9	Enterobacterial_phage	8.8e-16	48.9
WP_012668324.1\|2282115_2282496_-\|holin	holin	F1C592	Cronobacter_phage	2.2e-30	57.9
WP_012668325.1\|2282869_2283790_+	exopolysaccharide protein, Mig-14 family	NA	NA	NA	NA
WP_104945024.1\|2283911_2285046_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	6.9e-80	55.8
WP_012668326.1\|2286274_2287111_+	hypothetical protein	NA	NA	NA	NA
WP_012668327.1\|2287231_2287792_-\|tail	tail fiber assembly protein	F1BUK2	Cronobacter_phage	1.2e-29	44.2
WP_012668328.1\|2287788_2288751_-	hypothetical protein	Q8HAB4	Salmonella_phage	1.4e-25	57.7
WP_012668329.1\|2288743_2289325_-	DUF2313 domain-containing protein	A0A192Y5V3	Salmonella_phage	6.8e-92	78.8
WP_012668330.1\|2289327_2290401_-\|plate	baseplate J/gp47 family protein	A0A192Y6E4	Salmonella_phage	8.0e-147	71.0
WP_012668331.1\|2290393_2290807_-	phage GP46 family protein	A0A192Y6D0	Salmonella_phage	4.6e-50	68.6
WP_012668332.1\|2290806_2291343_-\|plate	phage baseplate assembly protein	U5P081	Shigella_phage	3.2e-35	49.4
WP_012668333.1\|2291342_2292419_-\|plate	baseplate protein	U5P0H6	Shigella_phage	1.1e-146	70.0
WP_012668334.1\|2292415_2293717_-	DNA circularization N-terminal domain-containing protein	Q8SBG8	Shigella_phage	2.2e-143	58.9
WP_012668335.1\|2293752_2295660_-\|tail	phage tail tape measure protein	U5P420	Shigella_phage	4.0e-181	56.3
WP_012668336.1\|2295744_2296068_-\|tail	phage tail assembly protein	Q8HAC3	Salmonella_phage	5.7e-24	56.1
WP_012668337.1\|2296064_2296421_-	hypothetical protein	Q8W622	Enterobacteria_phage	1.8e-50	81.4
WP_012668338.1\|2296420_2297917_-\|tail	tail sheath protein	Q8HAC5	Salmonella_phage	4.2e-194	68.3
WP_012668339.1\|2297916_2298096_-	DUF2635 domain-containing protein	Q8SBH3	Shigella_phage	4.0e-11	58.2
WP_012668340.1\|2298099_2298660_-	hypothetical protein	A0A192Y5U4	Salmonella_phage	2.1e-69	67.2
WP_012668341.1\|2298656_2299163_-	hypothetical protein	Q8HAC8	Salmonella_phage	4.4e-71	78.3
WP_012668342.1\|2299155_2299545_-\|head	phage head closure protein	U5P0R0	Shigella_phage	1.8e-35	58.1
WP_012668343.1\|2299546_2299876_-\|head,tail	phage gp6-like head-tail connector protein	Q8SBH7	Shigella_phage	5.0e-23	51.9
WP_148217836.1\|2299885_2300302_-	hypothetical protein	K7PHI6	Enterobacteria_phage	2.4e-06	68.4
WP_012668345.1\|2300343_2301561_-\|capsid	phage major capsid protein	K7PM57	Enterobacteria_phage	3.7e-180	80.2
WP_012668346.1\|2301570_2302419_-\|protease	Clp protease ClpP	K7PH05	Enterobacteria_phage	5.3e-101	68.0
WP_012668347.1\|2302430_2303735_-\|portal	phage portal protein	K7PJU5	Enterobacteria_phage	1.1e-190	74.7
WP_014539025.1\|2303734_2305480_-\|terminase	terminase large subunit	M4QNU0	Tetraselmis_viridis_virus	1.1e-132	43.5
WP_012668349.1\|2305433_2305901_-\|terminase	phage terminase small subunit P27 family	Q9B019	Phage_GMSE-1	5.5e-44	58.4
WP_014539028.1\|2306222_2306573_-	HNH endonuclease	F1C587	Cronobacter_phage	2.8e-40	67.3
WP_081441639.1\|2306550_2307066_-\|lysis	lysis protein	A0A0M4RD57	Salmonella_phage	5.0e-22	53.3
WP_041474005.1\|2307110_2307530_-	structural protein	X2KPC6	Enterobacteria_phage	1.2e-37	53.2
WP_012668353.1\|2307510_2307858_-\|holin	phage holin, lambda family	Q8SBE1	Shigella_phage	2.7e-35	66.4
WP_041474006.1\|2308016_2308199_+	type II toxin-antitoxin system HicA family toxin	A0A0D4DC32	Acinetobacter_phage	1.8e-11	54.2
WP_012668354.1\|2308254_2308668_+	type II toxin-antitoxin system HicB family antitoxin	A0A0D4DCG1	Acinetobacter_phage	1.9e-16	35.6
WP_012668355.1\|2308722_2309781_-	site-specific DNA-methyltransferase	Q6UAT0	Klebsiella_phage	1.5e-113	68.7
WP_012668356.1\|2309929_2310130_-	hypothetical protein	A0A291AWX6	Escherichia_phage	3.7e-05	42.4
WP_012668357.1\|2310366_2311182_+	hypothetical protein	NA	NA	NA	NA
WP_012668358.1\|2311187_2311481_+	hypothetical protein	NA	NA	NA	NA
WP_012668359.1\|2311516_2311888_-	antitermination protein	U5P0A5	Shigella_phage	8.6e-32	55.4
WP_012668360.1\|2311880_2312957_-	DUF968 domain-containing protein	A0A291AWV9	Escherichia_phage	7.1e-127	62.8
WP_012668361.1\|2312953_2313835_-	phage N-6-adenine-methyltransferase	Q8HA94	Salmonella_phage	9.9e-127	72.0
WP_012668362.1\|2313828_2314281_-	PerC family transcriptional regulator	NA	NA	NA	NA
WP_012668363.1\|2314277_2315330_-	helix-turn-helix domain-containing protein	H9C164	Pectobacterium_phage	9.0e-34	39.0
WP_012668364.1\|2315326_2315509_-	DUF4222 domain-containing protein	NA	NA	NA	NA
WP_012668365.1\|2315505_2316318_-	hypothetical protein	A0A248SL11	Klebsiella_phage	2.6e-41	46.2
WP_012668366.1\|2316314_2316506_-	hypothetical protein	NA	NA	NA	NA
WP_012668367.1\|2316570_2317035_-	hypothetical protein	K7PJS5	Enterobacterial_phage	3.3e-57	71.5
WP_012668368.1\|2317054_2317279_-	transcriptional regulator	A0A0N7C1T6	Escherichia_phage	6.2e-09	50.0
WP_012668369.1\|2317385_2317976_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_049779063.1\|2318871_2319111_+	hypothetical protein	NA	NA	NA	NA
WP_012668371.1\|2319088_2319322_-	hypothetical protein	NA	NA	NA	NA
WP_012668372.1\|2319626_2319998_+	hypothetical protein	Q8HAA1	Salmonella_phage	1.5e-55	87.8
WP_012668373.1\|2320057_2320885_+	DUF2303 family protein	Q8HAA2	Salmonella_phage	2.9e-136	88.7
WP_012668374.1\|2321017_2321548_+	hypothetical protein	K7PKJ9	Enterobacteria_phage	3.2e-56	62.6
WP_012668375.1\|2321540_2321984_+	hypothetical protein	Q7Y3W7	Yersinia_phage	1.8e-36	61.7
WP_014539038.1\|2321958_2322636_+	hypothetical protein	A0A077KCB2	Edwardsiella_phage	1.5e-69	53.7
WP_081441640.1\|2322746_2323022_+	DUF551 domain-containing protein	K7PH61	Enterobacteria_phage	3.3e-20	62.9
WP_012668378.1\|2323018_2323588_+	3'-5' exoribonuclease	K7PLW7	Enterobacteria_phage	3.5e-85	77.2
WP_041474008.1\|2323630_2323876_+	excisionase	NA	NA	NA	NA
WP_012668379.1\|2323856_2324984_+\|integrase	tyrosine-type recombinase/integrase	O21925	Phage_21	2.7e-121	58.4
WP_012668380.1\|2325017_2326385_+	ATP-binding protein	NA	NA	NA	NA
WP_012668381.1\|2326490_2327741_-	NADP-dependent isocitrate dehydrogenase	Q77Z09	Phage_21	9.7e-19	88.9
2327632:2327646	attR	NA	NA	NA	NA
WP_012668382.1\|2327844_2328501_+	23S rRNA pseudouridine(2457) synthase RluE	NA	NA	NA	NA
WP_012668383.1\|2328548_2329025_+	NUDIX hydrolase	NA	NA	NA	NA
WP_012668384.1\|2329134_2330244_+\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA

DBSCAN-SWA_5

2887225 : 2894483

Bacillus_virus(33.33%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012668875.1\|2887225_2887498_-	transcriptional regulator	A3E2K9	Sodalis_phage	8.0e-19	51.1
WP_012668876.1\|2887689_2890044_-	endopeptidase La	A0A0R6PGP8	Moraxella_phage	6.5e-226	53.3
WP_012668877.1\|2890233_2891508_-\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.6e-130	55.6
WP_012668878.1\|2891820_2892417_+\|protease	ATP-dependent Clp protease proteolytic subunit	A0A248SJ97	Salicola_phage	2.1e-27	36.8
WP_012668879.1\|2892489_2893764_-\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	2.8e-130	55.4
WP_012668880.1\|2893859_2894483_-	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	5.4e-63	61.5

DBSCAN-SWA_6

3452249 : 3460758

Brevibacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012667450.1\|3452249_3453320_+	site-specific tyrosine recombinase XerC	A0A0K2CP59	Brevibacillus_phage	8.9e-13	23.0
WP_012667449.1\|3453345_3454104_+	hypothetical protein	NA	NA	NA	NA
WP_012669373.1\|3454610_3455063_+	SMI1/KNR4 family protein	NA	NA	NA	NA
WP_012669374.1\|3455122_3455425_-	type I addiction module toxin, SymE family	NA	NA	NA	NA
WP_012669375.1\|3455503_3455905_-	helix-turn-helix domain-containing protein	A0A0A7AQV8	Bacillus_phage	1.8e-06	33.7
WP_012669376.1\|3456017_3458711_+	toprim domain-containing protein	A0A1S5RF71	Helicobacter_phage	7.7e-21	24.8
WP_012669377.1\|3458925_3459981_+	site-specific tyrosine recombinase XerC	A0A0K2CP59	Brevibacillus_phage	2.7e-14	27.3
WP_012669378.1\|3460241_3460484_+	type II toxin-antitoxin system RelB/DinJ family antitoxin	A0A2H4JBG1	uncultured_Caudovirales_phage	1.1e-14	47.5
WP_012669379.1\|3460473_3460758_+	type II toxin-antitoxin system RelE/ParE family toxin	A0A2H4JBF4	uncultured_Caudovirales_phage	1.4e-29	69.1

DBSCAN-SWA_7

3483405 : 3505347

uncultured_virus(80.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012666458.1\|3483405_3484446_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_012669399.1\|3484570_3485923_+	adenylate/guanylate cyclase domain-containing protein	NA	NA	NA	NA
WP_012669401.1\|3486604_3489406_-	conjugative transfer ATPase	NA	NA	NA	NA
WP_041474143.1\|3489405_3489804_-	TIGR03751 family conjugal transfer lipoprotein	NA	NA	NA	NA
WP_012669402.1\|3489839_3491357_-	TIGR03752 family integrating conjugative element protein	NA	NA	NA	NA
WP_012669263.1\|3491356_3492220_-	TIGR03749 family integrating conjugative element protein	NA	NA	NA	NA
WP_012669264.1\|3492216_3492876_-	TIGR03746 family integrating conjugative element protein	NA	NA	NA	NA
WP_012669265.1\|3492872_3493247_-	TIGR03750 family conjugal transfer protein	NA	NA	NA	NA
WP_012669266.1\|3493256_3493616_-	TIGR03745 family integrating conjugative element membrane protein	NA	NA	NA	NA
WP_004168502.1\|3493628_3493874_-	TIGR03758 family integrating conjugative element protein	NA	NA	NA	NA
WP_004168501.1\|3493864_3494185_-	hypothetical protein	NA	NA	NA	NA
WP_012669403.1\|3494326_3494632_-	DUF1493 family protein	NA	NA	NA	NA
WP_012669404.1\|3494625_3495090_-	hypothetical protein	NA	NA	NA	NA
WP_012669405.1\|3495559_3496090_+	hypothetical protein	NA	NA	NA	NA
WP_012669406.1\|3496146_3497310_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	4.2e-48	51.2
WP_012669407.1\|3497366_3498575_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.9e-51	50.3
WP_012669407.1\|3499392_3500601_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.9e-51	50.3
WP_012669409.1\|3500719_3500944_-	hypothetical protein	NA	NA	NA	NA
WP_104944977.1\|3501673_3502823_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	1.1e-48	40.4
WP_012669415.1\|3504138_3505347_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	2.4e-51	50.3

DBSCAN-SWA_8

3835329 : 3898435

Liberibacter_phage(10.0%)

protease,integrase,transposase

attL 3834544:3834559|attR 3861383:3861398

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
3834544:3834559	attL	NA	NA	NA	NA
WP_014539804.1\|3835329_3836151_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_014539807.1\|3838529_3841220_-	hypothetical protein	NA	NA	NA	NA
WP_014539808.1\|3841599_3842442_+	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	NA	NA	NA	NA
WP_015899152.1\|3842546_3843461_-	ribonuclease Z	NA	NA	NA	NA
WP_014539810.1\|3843480_3846531_-	type I restriction endonuclease subunit R	NA	NA	NA	NA
WP_014539811.1\|3846587_3847490_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_012666458.1\|3847620_3848661_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_014539812.1\|3849021_3851403_-	SAM-dependent DNA methyltransferase	A0A220A2U4	Liberibacter_phage	4.5e-25	28.5
WP_015899154.1\|3851757_3853113_+	glutathione-disulfide reductase	A0A2K5B2C5	Erysipelothrix_phage	2.3e-37	27.5
WP_014539814.1\|3853896_3854718_+	alpha/beta hydrolase	A0A1J0GVH7	Mycobacterium_phage	2.7e-17	30.1
WP_148217846.1\|3855371_3855800_+	hypothetical protein	NA	NA	NA	NA
WP_014539816.1\|3855757_3856282_-	cytochrome b561	NA	NA	NA	NA
WP_157861022.1\|3857102_3857375_+	hypothetical protein	NA	NA	NA	NA
WP_015899156.1\|3857375_3857681_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_014539820.1\|3857677_3857962_-	DNA-damage-inducible protein J	NA	NA	NA	NA
WP_015899158.1\|3857933_3858641_-\|integrase	tyrosine-type recombinase/integrase	S5W9T9	Leptospira_phage	1.0e-09	31.0
WP_014539822.1\|3858663_3858855_+	type I toxin-antitoxin system SymE family toxin	NA	NA	NA	NA
WP_014539823.1\|3859112_3861179_-	filamentous hemagglutinin N-terminal domain-containing protein	A0A0R6PJK4	Moraxella_phage	4.4e-32	34.3
WP_015899161.1\|3863121_3864084_-	oxidoreductase	NA	NA	NA	NA
3861383:3861398	attR	NA	NA	NA	NA
WP_015899162.1\|3864092_3865127_-	molybdenum cofactor-independent xanthine hydroxylase subunit HpxD	NA	NA	NA	NA
WP_014539828.1\|3865248_3866163_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_081441643.1\|3866194_3867049_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_014542734.1\|3867450_3867948_-	TIGR00645 family protein	NA	NA	NA	NA
WP_014539833.1\|3869227_3870502_+	HlyD family secretion protein	NA	NA	NA	NA
WP_014539834.1\|3870494_3872594_+	peptidase domain-containing ABC transporter	W8CYL7	Bacillus_phage	9.5e-35	26.5
WP_014539835.1\|3873030_3873771_-	ankyrin repeat domain-containing protein	NA	NA	NA	NA
WP_014539836.1\|3873767_3874544_-	phospholipase	NA	NA	NA	NA
WP_014539837.1\|3874582_3875485_-	siderophore-interacting protein	NA	NA	NA	NA
WP_015899165.1\|3875670_3876798_+	N-acetyltransferase	NA	NA	NA	NA
WP_014539842.1\|3878906_3879218_+	hypothetical protein	NA	NA	NA	NA
WP_014539843.1\|3879245_3880421_+	HNH endonuclease	G0X580	Salmonella_phage	4.4e-21	46.3
WP_014539844.1\|3880693_3881710_-	SMP-30/gluconolactonase/LRE family protein	NA	NA	NA	NA
WP_014539845.1\|3881722_3882301_-	hypothetical protein	NA	NA	NA	NA
WP_104944977.1\|3882469_3883620_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	1.1e-48	40.4
WP_104945181.1\|3884516_3884891_+	hypothetical protein	NA	NA	NA	NA
WP_014539848.1\|3885195_3887895_-	two-component system sensor histidine kinase KdbD	NA	NA	NA	NA
WP_014539849.1\|3887904_3888477_-	potassium-transporting ATPase subunit KdpC	NA	NA	NA	NA
WP_014539850.1\|3888488_3890537_-	potassium-transporting ATPase subunit KdpB	M1HBF8	Paramecium_bursaria_Chlorella_virus	3.0e-25	24.0
WP_014539851.1\|3890555_3892241_-	potassium-transporting ATPase subunit KdpA	NA	NA	NA	NA
WP_004163493.1\|3892240_3892330_-	K(+)-transporting ATPase subunit F	NA	NA	NA	NA
WP_014539854.1\|3893051_3893249_-	hypothetical protein	NA	NA	NA	NA
WP_015899169.1\|3893555_3894248_+	hypothetical protein	NA	NA	NA	NA
WP_049779068.1\|3894524_3894614_-	K(+)-transporting ATPase subunit F	NA	NA	NA	NA
WP_015899171.1\|3894833_3896042_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.9e-51	50.3
WP_014539858.1\|3896368_3896764_+	polyketide cyclase	NA	NA	NA	NA
WP_014539859.1\|3896812_3897733_+	nucleoside hydrolase	NA	NA	NA	NA
WP_014539860.1\|3897922_3898156_+	DUF1471 domain-containing protein	NA	NA	NA	NA
WP_015899173.1\|3898186_3898435_-\|protease	AprI/Inh family metalloprotease inhibitor	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_013263

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_012214

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection