CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_008702	Azoarcus olearius, complete genome	4 crisprs	csa3,WYL,cas3,DEDDh,DinG	0	0	2	0

1. NC_008702

CRISPR-Cas detection and classification

Crispr_ID: NC_008702_1

• CRISPR_ID: NC_008702_1
• CRISPR_location: 721284-721387
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_008702_1

Consensus_repeat	Method
CCGTGCAGCGGGCGGGGGCAGAAAA	CRISPRCasFinder

spacers of NC_008702_1

>1.1|721309|54|NC_008702|CRISPRCasFinder
CCGCGATCGCCGCCGGGCCGTCCCAAGGCGATCGCGTGCCCCCTCGGGGGGCGA

CRISPR arrays and Neighbor proteins around NC_008702_1

CRISPR arrays

The CRISPR arrays of NC_008702_1

>merge|NC_008702|1|721284-721387|CRISPRCasFinder
CCGTGCAGCGGGCGGGGGCAGAAAACCGCGATCGCCGCCGGGCCGTCCCAAGGCGATCGCGTGCCCCCTCGGGGGGCGACCGCGCAGCGGGCGGGGGCAGAAAA

>NC_008702|1|1|721284-721387|CRISPRCasFinder
CCGTGCAGCGGGCGGGGGCAGAAAA	CCGCGATCGCCGCCGGGCCGTCCCAAGGCGATCGCGTGCCCCCTCGGGGGGCGA
CCGCGCAGCGGGCGGGGGCAGAAAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_008702.1|WP_011764415.1|716526_717309_-|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|180424
NC_008702.1|WP_011764426.1|734004_734865_+|neutral-zinc-metallopeptidase	unknown	unknown	gnl|CDD|282131
NC_008702.1|WP_011764423.1|727371_729378_+|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	unknown	unknown	gnl|CDD|227111
NC_008702.1|WP_011764422.1|725697_727233_+|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl|CDD|227136
NC_008702.1|WP_011764409.1|709009_710266_+|urea-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|372603
NC_008702.1|WP_011764421.1|724618_725632_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl|CDD|236515
NC_008702.1|WP_011764419.1|721388_722060_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224715
NC_008702.1|WP_011764425.1|732025_733909_+|diguanylate-cyclase	unknown	unknown	gnl|CDD|143635
NC_008702.1|WP_011764417.1|717875_719555_+|cation-acetate-symporter	unknown	unknown	gnl|CDD|236495
NC_008702.1|WP_011764413.1|714833_715526_+|urea-ABC-transporter-ATP-binding-subunit-UrtE	unknown	unknown	gnl|CDD|274567
NC_008702.1|WP_011764414.1|715559_716513_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176152
NC_008702.1|WP_148268714.1|710546_712166_+|urea-ABC-transporter-permease-subunit-UrtB	unknown	unknown	gnl|CDD|200272
NC_008702.1|WP_148268802.1|719714_721004_+|DUF21-domain-containing-protein	unknown	unknown	gnl|CDD|224173
NC_008702.1|WP_011764428.1|735948_736680_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NC_008702.1|WP_011764427.1|734886_735363_-|VOC-family-protein	unknown	unknown	gnl|CDD|372667
NC_008702.1|WP_011764424.1|729560_732017_+|EAL-domain-containing-protein	unknown	unknown	gnl|CDD|236645
NC_008702.1|WP_011764420.1|722386_724552_+|methylmalonyl-CoA-mutase	unknown	unknown	gnl|CDD|236508
NC_008702.1|WP_011764411.1|712359_713553_+|urea-ABC-transporter-permease-subunit-UrtC	unknown	unknown	gnl|CDD|132449
NC_008702.1|WP_041643233.1|717567_717876_+|DUF485-domain-containing-protein	unknown	unknown	gnl|CDD|377315
NC_008702.1|WP_011764412.1|713549_714407_+|urea-ABC-transporter-ATP-binding-protein-UrtD	unknown	unknown	gnl|CDD|274568

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_008702.1|WP_011764415.1|716526_717309_-|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|180424	PRK06144, PRK06144, enoyl-CoA hydratase; Provisional.	6.53919e-67
NC_008702.1|WP_011764426.1|734004_734865_+|neutral-zinc-metallopeptidase	gnl|CDD|282131	pfam04228, Zn_peptidase, Putative neutral zinc metallopeptidase. Members of this family have a predicted zinc binding motif characteristic of neutral zinc metallopeptidases (Prosite:PDOC00129).	8.14255e-134
NC_008702.1|WP_011764423.1|727371_729378_+|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	gnl|CDD|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NC_008702.1|WP_011764422.1|725697_727233_+|acyl-CoA-carboxylase-subunit-beta	gnl|CDD|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NC_008702.1|WP_011764409.1|709009_710266_+|urea-ABC-transporter-substrate-binding-protein	gnl|CDD|372603	pfam13433, Peripla_BP_5, Periplasmic binding protein domain. This domain is found in a variety of bacterial periplasmic binding proteins.	0
NC_008702.1|WP_011764421.1|724618_725632_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl|CDD|236515	PRK09435, PRK09435, methylmalonyl Co-A mutase-associated GTPase MeaB.	0
NC_008702.1|WP_011764419.1|721388_722060_-|GntR-family-transcriptional-regulator	gnl|CDD|224715	COG1802, GntR, Transcriptional regulators [Transcription].	7.57648e-50
NC_008702.1|WP_011764425.1|732025_733909_+|diguanylate-cyclase	gnl|CDD|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.54678e-63
NC_008702.1|WP_011764417.1|717875_719555_+|cation-acetate-symporter	gnl|CDD|236495	PRK09395, actP, cation/acetate symporter ActP.	0
NC_008702.1|WP_011764413.1|714833_715526_+|urea-ABC-transporter-ATP-binding-subunit-UrtE	gnl|CDD|274567	TIGR03410, urea_trans_UrtE, urea ABC transporter, ATP-binding protein UrtE. Members of this protein family are ABC transporter ATP-binding subunits associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. [Transport and binding proteins, Amino acids, peptides and amines].	6.41128e-144
NC_008702.1|WP_011764414.1|715559_716513_+|LysR-family-transcriptional-regulator	gnl|CDD|176152	cd08463, PBP2_DntR_like_4, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold. This CD includes an uncharacterized LysR-type transcriptional regulator similar to DntR, NahR, and LinR, which are involved in the degradation of aromatic compounds. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.188e-111
NC_008702.1|WP_148268714.1|710546_712166_+|urea-ABC-transporter-permease-subunit-UrtB	gnl|CDD|200272	TIGR03409, urea_trans_UrtB, urea ABC transporter, permease protein UrtB. Members of this protein family are ABC transporter permease proteins associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. [Transport and binding proteins, Amino acids, peptides and amines].	7.93042e-144
NC_008702.1|WP_148268802.1|719714_721004_+|DUF21-domain-containing-protein	gnl|CDD|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	4.69732e-129
NC_008702.1|WP_011764428.1|735948_736680_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.51985e-76
NC_008702.1|WP_011764427.1|734886_735363_-|VOC-family-protein	gnl|CDD|372667	pfam13669, Glyoxalase_4, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	2.32601e-38
NC_008702.1|WP_011764424.1|729560_732017_+|EAL-domain-containing-protein	gnl|CDD|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	9.20256e-127
NC_008702.1|WP_011764420.1|722386_724552_+|methylmalonyl-CoA-mutase	gnl|CDD|236508	PRK09426, PRK09426, methylmalonyl-CoA mutase; Reviewed.	0
NC_008702.1|WP_011764411.1|712359_713553_+|urea-ABC-transporter-permease-subunit-UrtC	gnl|CDD|132449	TIGR03408, urea_trans_UrtC, urea ABC transporter, permease protein UrtC. Members of this protein family are ABC transporter permease proteins associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. [Transport and binding proteins, Amino acids, peptides and amines].	9.00783e-159
NC_008702.1|WP_041643233.1|717567_717876_+|DUF485-domain-containing-protein	gnl|CDD|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	1.91692e-29
NC_008702.1|WP_011764412.1|713549_714407_+|urea-ABC-transporter-ATP-binding-protein-UrtD	gnl|CDD|274568	TIGR03411, urea_trans_UrtD, urea ABC transporter, ATP-binding protein UrtD. Members of this protein family are ABC transporter ATP-binding subunits associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. [Transport and binding proteins, Amino acids, peptides and amines].	4.3096e-158

Protein sequences

>NC_008702.1|WP_148268802.1|719714_721004_+|DUF21-domain-containing-protein
MLNHLLLILLLIAVSAFFSLAEISLAAARKIKLQQLAEEGVADARRVLALQESPGSFFTVVQIALNAVAILGGIVGEQALSPYVESALRPFYDGPALGTVSFVIAFVFVTSMFVLLADLMPKRLAMVKPEAVAMRVVRPIQASMWLFAPLVWLFNSLADRLFGLFGVPSARADDITSDDILAMAEAGTRAGALLEQEQNLIRNVFELDARIVPSAMTSRDSVVYFTLGEAEDSIRRKMAAHPHGKFPVCESGIDDVIGYVDAKDLFRRILQGQDLSLRTQPIVRKVLMLPDTLTLFEALERFRDAKEDFALVISEYALVVGLLTLQDVMNTVMGELGSPYQEELIVRRDDCSWLIDGVTPIEDVMQALEIEVFEGFENYETIAGFLMYRLRKVPKRTDFVVYAGYKFEVVDIDNYRIDQVLVTREPAAA
>NC_008702.1|WP_011764417.1|717875_719555_+|cation-acetate-symporter
MNASRLSRLALGLASLPLSAAALAAGPAMEAAQKQPLNLHAIGMFFVFVLMTLGITYWAASRTKSASDFYTAGGGITGFQNGLAIAGDYMSAATLLGLTAMMYAQGVDAYIYMIAFFVGWPIILFLMAERLRNLGKFTFADITAYRLDQGKVRTMAAVSSLTVVCFYLVAQMVGAGQLIKLLFGLDYTVALFVVGALMMVYVTFGGMVATTWVQIIKACMLLLGGTTVMLLALSQFGFSFEALATRAMEVHKLGPKLFNPGSLLADPVTAISLGLGLMFGTAGLPHILMRFFTVTDAKEARKSVLYASGIIAYFFNVIALMGLAAILIVGQNPQYFEGGDLAGKIVGGGNMVAMHLAHAVGGNLLLGFLSAVAFATILAVVAGLALAGASAISHDIYARVIMKGRASETTEIRVSKFATIGLGVVAVLLGIVFEKMNVAFMVALAFGVAASANFPVLILSMYWKGLTTRGALAGGYLGLFSAVTFVVLSKSVWVDVLGNAAPIFPWTQPALFSMPLAFLATIVVSLLDSSHKARSEREAFEDQYVRAQTGVGAASAAAH
>NC_008702.1|WP_041643233.1|717567_717876_+|DUF485-domain-containing-protein
MYAHIRRNPRFAELVAKRTRFATLLAAIVLVVFYGFVLVVAFAPQIVGQRLSEGSNLTIGIVAGLFQFIFFWVLTFVYVRRANGEFDAINTEIVRAAWQEEK
>NC_008702.1|WP_011764415.1|716526_717309_-|enoyl-CoA-hydratase/isomerase-family-protein
MNGQILVDRGDAVATVSLSNPGKLNAVNAGMWRQLRAAFAELGADPGVRCIVLRGAGDEAFAAGGDIEEFRTVRATVDDALHYHEELVAAALNAIRDCPVPTVAAIRGACVGGGLEIAGCCDLRIAGASSRFGAPINKLGFSMYPGEMAGLLALVGPAVVLEILLEGRILDAAEALQKGLLSRVVDDANVFDEAAACAARIAAGAPLVARWHKQWAKRLQRPEPLSEAERRAAFDFLATEDYREGLEAFLAKRKPVFKGR
>NC_008702.1|WP_011764414.1|715559_716513_+|LysR-family-transcriptional-regulator
MANGCTWDSLDAHLLRVLHVLLTEGSVSRAARRLNQSQPAVSTALKRLRDITGDKLLVRSRTGMTPTERGAELLEPVRIALEQMERIAAGPEGFEPANSRRVFNIATPDYLNALMLGDIVADIHRQAPGAQVAFHSMTQTFDYPRALESGELDLVIGNWPNPPEHLRTAPLFEDRMVVMMRTGHPLAGAPLTLSAWLAAEHVVPTSYSVGQRGVVDVYLARERLRRNVVAHVPYFHMAPYMVLQSDLVFTAPARFASHYADFLPMAVVDAPAELPRMAYYLLWHDRSQHSAECRWLRERIIRAARPDPAPAPLRRVA
>NC_008702.1|WP_011764413.1|714833_715526_+|urea-ABC-transporter-ATP-binding-subunit-UrtE
MLKVDNLNQYYGGSHILRGLSFEVPVGKVTTLLGRNGVGKTTLLKTLMGLVPAASGTIHFGAQDITRAPSYNRVRAGIGYVPQGREIFPRLSVEENLLMGLATQPRGSSIPQRIFDMFPVLKQMMGRRGGDLSGGQQQQLAIGRALAFGPKLLILDEPTEGIQPSIIKDIERAIRSLAATGEMAILLVEQYYDFARALSDQYLVMERGEIVMRGEGANMDADGVREALAV
>NC_008702.1|WP_011764412.1|713549_714407_+|urea-ABC-transporter-ATP-binding-protein-UrtD
MTETTELERRARAFAEAGGRENWEGAAATGHVATGELDLSHNVILYLDDITVSFDGFRALNKLSLTIDAGELRCIIGPNGAGKTTMMDVITGKTRPDEGKAFFGQTLDLTRMTEPEIAHAGIGRKFQKPTIFENHSAFENLELAMKADKRVRRTLFASLFDDERDRIADVLKQIRLDKFADRSAGLLSHGQKQWLEIGMLLMQEPKLLLLDEPVAGMTDDETERTAELFVSLAGKHSLMVVEHDMAFVEALGGKVTVLCEGSVLAEGDLATVQADSRVIEVYLGR
>NC_008702.1|WP_011764411.1|712359_713553_+|urea-ABC-transporter-permease-subunit-UrtC
MRTPFTVRLFQSMPKTGWVALAIFAVVACVGVPVAHLALPEGHALHLSAYTVSLLGKILCYMVVAVAMDLIWGYAGILSLGHGLFFALGGYAFGMYLMRQIGRDGSYQSDLPDFMVFLDWKELPWYWAGSDSFLWALFLAMALPGLVAFVFGYFAFRSRIKGVYFSIITQALTYAAMLLFFRNETGFGGNNGFTDFKRILGYSITSPEMRATLFALSALLLIACLVLGRYLVSSRFGRVLAAIRDAESRVMFIGYNPLHYKLFMWTLSAVLCGLAGALYVPQVGIINPSEMSPANSIEIAVWVAVGGRGTLVGAVLGAGIVNLAKSFFTVTVPEYWPFFLGFLFIAVTLYLPDGVVGLWRKLRARKGPDSAAAAPAATAAPVGEAAPETTVAKGATA
>NC_008702.1|WP_148268714.1|710546_712166_+|urea-ABC-transporter-permease-subunit-UrtB
MNRLLLRLALLFASLACLALPARAALDPALVAGFAGDFNSRVAAIEALGVEGSAEARALLDAVEAGNLGVAADKVVVIDGDAVKDAASGEALQIPADEVETITVNNRIRRALATAHAALALSAESAADRLAAANTLTENTSESLLPLFERTLAGEKDEAVRGVLSRAVARVNLGSADAAKRLKAAEALGESSDPAVKNMLAALLEKRGEGKDASWAEPDAEVRAAAEASIKAIDRRIATAQAVGTVFSGLSLGSILLLAALGLAITYGVMGIINMAHGELLMVGAYATFLVQGLFRSYLPAYLDWYVVAAIPVAFFAAALVGVAMERLVLRHLYGRPLESLLATWGLSLVLIQAARVVFGPQNLELANPGWMSGGMELAAGVVLPYNRIVIIGFAVFVLVLIWLMMQKTRLGMFVRAVTQNRPMAGCVGVPTARVDTLAFAIGSGVAGLGGLALSQIANVGPAMGQGYIVDAFMVVVLGGVGQLAGAVWAALGLGIVAKFLEGWAGAVIAKILVLVFIIVFIQKRPQGIFALKGRFADS
>NC_008702.1|WP_011764409.1|709009_710266_+|urea-ABC-transporter-substrate-binding-protein
MQTRRSFIKALALSASIAAIGAPFGAHAADTIKVGILHSLSGTMAISETALKNVALMTIEEINAKGGVMGKKLEPVVVDPASNWPLFAEKARQLVAQDKVAAVFGCWTSVSRKSVNPVFKELNGLLFYPVQYEGEELEKNVFYTGAAPNQQAIPAVEYLMSAEGGSAKRFVLLGTDYVYPRTTNKILRAFLKSKGVADADIMEDYTPFGHSDYQTIIANIKKFASEGKKTAVISTINGDSNVPFYKELGNAGLKATDVPVVAFSVGEEELRGVDTKPLVGHLAAWNYFMTVKNPENTAFIKKYKDWAKKNGVPNADTVVTNDPMEATYVGIYMWKQAVEKAKSTDTDKVIAALGGQTFKAPSGFTLTMDKTNHHLHKPVFIGEVRADGQFDVVWKTKEPIRAQPWSPFIPGNEGKQGL
>NC_008702.1|WP_011764419.1|721388_722060_-|GntR-family-transcriptional-regulator
MTASRIAPLALYQEVAERLRERIFSHELPPGTWVDEQALAEQYGISRTPLREALKVLASEGLVTLKPRRGCYVTEISERDLDEVFNIIALLEGECARASVARASDADLARLRDIHATLEAAAAAQDIDRFFEANQAFHHVLQQIADNRWLLQVIEDLRKVIKLSRHHSLFSEGRLEQSLAEHREILEAVLARDPDAAETRMRRHIHSGRAALSRIAEARNRAA
>NC_008702.1|WP_011764420.1|722386_724552_+|methylmalonyl-CoA-mutase
MSNANLPAYPQPDLEAWNKAAAKQAPDGQLDKLNWITPEGLTVKPLYTKADTADLPHADTLPGFEPFLRGPQPTMYAVKPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDNPRVLGDVGKAGVAIDSVEDMKILFDGIPLDKISVSMTMNGAVLPILAGYIVAAEEQGVAQDKLSGTIQNDILKEFMVRNTYIYPPTPSMKIIADIFQYTSSHMPKFNSISISGYHIQEAGANQAIELAFTLADGLEYVRTGIAAGMDVDTFAGRLSFFWAVGMNFYLEIAKMRAARLLWWRIMKQFNPKSPKSMMLRTHSQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNALDEAIALPTEFSARIARNTQIIIQEETHICNVVDPWAGSYMMEKLTQDMADKAWALIEEIEAMGGMTKAVESGWAKMKVEECAADKQARIDSGKDVIVGVNKYKLAKEDPIEILDIDNHAVREAQIARLTKIRATRDSAAVQAALDALTQCAESGEGNLLDLAVKAVRLRASVGEISDALEKVFGRYRANPQAVSGVYGAVVEDDADWKELKAEIEAFIAEEGRRPRIMIAKLGQDGHDRGAKVVASAFADLGFDIDIGPLFQTPEEAARHAVENDVHAVGCSSLAAGHKTLVPAIIAELKRLGAEDIITFVGGVIPAQDYDALYAAGAKGIFGPGTPIPKAAREVLKQIRAAKVAA
>NC_008702.1|WP_011764421.1|724618_725632_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MAMNMPESLPVLDDADLALVEGVRARQLRPLAKTITLIESQREDHKARARAVLEALLPHTGGAMRVGISGVPGVGKSTFIEALGLYLIEQGLRVAVLAVDPSSSLTGGSILGDKTRMELLSQNPAAFIRPSPSAGSLGGVAEKTRETLLVCEAAGFDVIIVETVGVGQSETAVAGMTDIFCLLQLPNAGDDLQAIKKGIMEIADLIVINKADIDAGAAMRAKSQMKTALHMLRPASPNWTVPVLTLSALKKDGIAEFWNAVQDYRGAMTKSGEFEAKRRHQALAWMWELIDTGLRSRFRNHPGVRDALPLLAAAVEAGGTTPSAAAQRLLGCLNRTN
>NC_008702.1|WP_011764422.1|725697_727233_+|acyl-CoA-carboxylase-subunit-beta
MHDIIRQLDEKRAAARLGGGQKRIDSQHAKGKLTARERIELLLDPDSFEEWDMFKEHRCVDFGMDKAEKTPGDGVVTGYGTINGRLVFVFSQDFTVFGGSLSETHAEKICKVMDHAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQRNVMASGVIPQISMIMGPCAGGAVYSPSMTDFIFMVKDSSYMFVTGPEVVKTVTHEDVTAEELGGAVTHTSKSGVADLAFENDVEALTMLRRFMNYLPSSNREKPPVQPTNDPADRQDFSLDTLVPDNPNKPYDMKELIIKVVDDCDFFELQPDYAKNIIIGMARMDGQPVGIVANQPLVLAGCLDIKSAIKAARFVRFCDAFNIPVVTFVDVPGFMPGTAQEYGGIIKHGAKLLYAYAECTVPKVTVITRKAYGGAYDVMASKHLRGDVNLAWPSAEIAVMGPKGAVEIIFREEKNNPEKLAEREAEYKAKFANPFVAASRGFIDDVVMPHNTRKRICRSLAMLADKQLDNPWRKHGNIPL
>NC_008702.1|WP_011764423.1|727371_729378_+|acetyl-CoA-carboxylase-biotin-carboxylase-subunit
MFTKILIANRGEIACRVIKTARKMGIKTVAVYSEADKDALHVDLADEAVCIGPAPSKDSYLVMDRIIAACKQTGAEAVHPGYGFLSENAEFSRRLEEEGIKFIGPKHYSVAKMGDKIESKKLAIEAKVNTIPGYNDAIAGPAEAVEIAKKIGYPVMIKASAGGGGKGLRVAYNDEQAFEGFSSCVNEARNSFGDDRVFIEKYVLEPRHIEIQVLGDSHGNYVYLNERDCSIQRRHQKVIEEAPSPFVDAEMRKAMGEQAVALARAVNYESAGTVEFVVSGATKEFYFLEMNTRLQVEHPVTELITGLDLVEQMIRVAAGEKLPLSQADVKINGWAMECRINAEDPFRGFLPSTGRLVRFQPPAEVDGQVRVDTGVYDGGEISMFYDSMIAKLIVHGATRDQAIGRMRDALNAFVIRGISSNIPFQAALMQHPRFCSGNFNTGFIAEEFPKGFDASMVPHDDPALLAAVAAYVHRSYIDRAARVSGQLPGHERAVGNEWVVIRLGTDNQNELLPVTATPVAGGYAVTLNGETYTIKSDWQLGQALFNGTCNGNEFTLQVERHKMRYRLFHWGTQADFLVMSKRAAELQSLMPVKLPPDLSKFLLSPMPGLLREVSVSEGQEVKAGEKLAVIEAMKMENLLKAEQDGKVKKVVIKPGASLAVDDVIIEFE
>NC_008702.1|WP_011764424.1|729560_732017_+|EAL-domain-containing-protein
MEPTLPVDLETVADEGEDSLLRALIDVIPDLVFFKDEAGRYLGCNRAFEAYTGRREAELIGYTDRDLFDLSTADSYRGYDNAVLASGRSSRNEEWIVYPDGRRVLVDTLKTPFRDAASGRRGVVGISRDVTVFRETAEALRRSQENLERAQAVARTGSWYVDFVSGQMDWSAETCRLFGQAPGCVPSYELFLSVVHPEDQALVEAAWRQAVARGDYDLTHRVIVGGEVRWVHERAEFRRAADGAALAGIGTVQDITDRKLAEQSLRQAATVFENTGEGVIIADAKNRIIAVNRAFTVITGYGPEEVIGRSPNLLRSGRHDAAYYDAMWRGVHEAGHWQGEIWNRRKNGEIFPELLTLSVVRDHNGKVSHYVGVFSDISRMKETEARLQRLAHYDALTDLPNRVLLNLRLAHGVERVQRSGEMLAVLFLDIDRFKNVNDSLGHPVGDELLIEIARRLRSRIRAEDTLARLGGDEFVILLDRIRSANDVADFAQEIIDLLNQSFQLASGQEVFVGASIGISLYPLDTDDATQLISNADAALYQAKEAGRNVYRFYTADLTRAAHERLGLEAALRRGLERGEFVLHFQPVVALDKGEVVGAEALVRWNHPTEGMIAPLRFIPLAEETGLIVPLGEWVLESACRQGREWLDCGRPLTIAVNLSTRQFRAGDLTATVRDILDRTGFPAALLELEITESTVMEDADRAVATLAALKGLGVRLSIDDFGTGYSSLAYLKRFAVDALKIDRSFVRDIADDENDRMIVATVVAMAHQMRLGVIAEGVETAEQLAFLRSLGCEAYQGYLVGRPQAAADFLGAVERAGI
>NC_008702.1|WP_011764425.1|732025_733909_+|diguanylate-cyclase
MTSVRQWAARLIWAMLAWALAIAAGGARADDIALDPAHGEVDLARRVSVLVDDGRSLSLEAAKAAFARGEGAPAEPARGGELNFGYRAADIWLHFSVAAAAPDDARWLLEVGFPSLDRVEFHAFGPGGEAHQVAGDRIAFHARPWQHRSPVFPLPQLAPGERLEVYVKVASEGSLTVPLRLWTQTALGARDQRAYSEDALYFGMLTALALYNLLLWVALREQVFLRYVGFVASLAVGFAGQTGAGGEFLWPAWPTWSHLSFPVGMALTGFFGTLFTRSFLDTRNTVPRLDRCLAVAAWVFLAAVAAHLVVGYRFAAMLTSLAGIGFAPIAALAGVRGAVRGHPGARVFLLAWALLLVGVVVMAMRNFGWLPTVWLTTHAMQIGSALEMLLLSFAMADRINVMRREREAARQALVDTLQEAGQRLEQRVAERTAELQAANRRLRDNELALQQLAFHDPLTGLYNRVMLEERIRHAMLRADRQDTQLAVLLLDLDGFKAVNDGYGHAVGDAVLAAAATRMKAQVRASDTVARLGGDEFVVVLEPFSGEDQAVRVAAKLVAALAEPVVESGVAHQIGASIGIALYPADGRDVDQLILAADRAMYRVKAAGKGGWRRNSPEQAAHPAGLRP
>NC_008702.1|WP_011764426.1|734004_734865_+|neutral-zinc-metallopeptidase
MRFDHGRESDNIEDRRGEGGGGFRLGGGGKLGLGGIVLTLVALYFGVDPALLLQTAEVVRPPAAVERPASRPQDEAGRFVSMVLADTEDTWSDIFSGAGRTYQAPRLVLFSGVTGTACGTGQAAMGPFYCPADQKVYIDLSFYDDLQQRFRAPGDFAQAYVIAHEIGHHVQNLLGVSERAQRARARLSPRESNALSVRLELQADCFAGVWAHHADRSRQVLEAGDVEEALTAAAAIGDDRLQKQAQGYAVPDSFTHGSAEQRVRWFRTGLQHGSLQACDTFAARSP
>NC_008702.1|WP_011764427.1|734886_735363_-|VOC-family-protein
MSQRPFKILGVQQIAIGGPSKEKLKTFWVDMLGLEVTGNFVSERENVDEDICAMGKGPFKVEVDLMQPLDPEKKPAVHATPLNHIGLWVDDLPVAVEWLTAQGVRFAPGGIRRGAAGYDITFLHPKGNEEFPIGGEGVLVELVQAPPEVVEAFARLAG
>NC_008702.1|WP_011764428.1|735948_736680_-|response-regulator-transcription-factor
MSATRPEASPPTIFVLEDEPDIARLICSSLTEYGFRCEHLTTGRQLLQRARQQTPDLCIVDLGLPDMDGMQVVRELQDGSPCAVLILTGRNDVTDRVLGLELGADDYIVKPFEPRELVARVRSILRRYQRSAPPETSAAEKTVARFAGWTFDGGRLTMTAPDGREVNLSAAEASLLAVLLRRPNKIFSREQLLGERDVDPFDRSIDVRISRLRRKLDDDPQNPRLIKTVYGAGYLFAAQVSWE

Crispr_ID: NC_008702_2

• CRISPR_ID: NC_008702_2
• CRISPR_location: 2173405-2173514
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_008702_2

Consensus_repeat	Method
CGGTCTTGTCCCCTCCCCTTCAAGGGG	CRISPRCasFinder

spacers of NC_008702_2

>2.1|2173432|56|NC_008702|CRISPRCasFinder
GTGAAGCTGGGGTTTCGGCAAACATCGTTTGCCGTCCGCTGAACGATGGAGCGCCG

CRISPR arrays and Neighbor proteins around NC_008702_2

CRISPR arrays

The CRISPR arrays of NC_008702_2

>merge|NC_008702|2|2173405-2173514|CRISPRCasFinder
CGGTCTTGTCCCCTCCCCTTCAAGGGGGTGAAGCTGGGGTTTCGGCAAACATCGTTTGCCGTCCGCTGAACGATGGAGCGCCGCGGTTTTGTCCCCTCCCCTTCAAGGGG

>NC_008702|2|2|2173405-2173514|CRISPRCasFinder
CGGTCTTGTCCCCTCCCCTTCAAGGGG	GTGAAGCTGGGGTTTCGGCAAACATCGTTTGCCGTCCGCTGAACGATGGAGCGCCG
CGGTTTTGTCCCCTCCCCTTCAAGGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_008702.1|WP_011765704.1|2167419_2168526_-|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl|CDD|223992
NC_008702.1|WP_011765705.1|2168584_2169613_-|4-hydroxy-2-oxovalerate-aldolase	unknown	unknown	gnl|CDD|181282
NC_008702.1|WP_011765717.1|2183638_2185273_+|AMP-binding-protein	unknown	unknown	gnl|CDD|341257
NC_008702.1|WP_011765710.1|2175413_2176190_+|cyclase-family-protein	unknown	unknown	gnl|CDD|224790
NC_008702.1|WP_011765708.1|2171447_2172401_-|3-carboxyethylcatechol-2,3-dioxygenase	unknown	unknown	gnl|CDD|153377
NC_008702.1|WP_011765712.1|2176748_2178953_+|indolepyruvate-ferredoxin-oxidoreductase-subunit-alpha	unknown	unknown	gnl|CDD|226684
NC_008702.1|WP_148268737.1|2176399_2176657_-|hypothetical-protein	unknown	unknown	unknown
NC_008702.1|WP_011765714.1|2180605_2181583_+|oxidoreductase	unknown	unknown	gnl|CDD|99782
NC_008702.1|WP_011765706.1|2169627_2170548_-|acetaldehyde-dehydrogenase-(acetylating)	unknown	unknown	gnl|CDD|236227
NC_008702.1|WP_011765716.1|2183142_2183625_+|aromatic-ring-hydroxylating-dioxygenase-subunit-beta	unknown	unknown	gnl|CDD|238357
NC_008702.1|WP_011765718.1|2185269_2186448_+|thiolase-family-protein	unknown	unknown	gnl|CDD|238425
NC_008702.1|WP_011765694.1|2173723_2175064_-|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl|CDD|239617
NC_008702.1|WP_011765700.1|2164556_2165000_-|lipocalin-like-domain-containing-protein	unknown	unknown	gnl|CDD|372819
NC_008702.1|WP_011765703.1|2166832_2167366_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380359
NC_008702.1|WP_011765707.1|2170616_2171411_-|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl|CDD|183092
NC_008702.1|WP_011765715.1|2181599_2182922_+|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl|CDD|239612
NC_008702.1|WP_011765709.1|2172425_2173322_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_008702.1|WP_011765702.1|2166073_2166811_+|FCD-domain-containing-protein	unknown	unknown	gnl|CDD|183181
NC_008702.1|WP_011765713.1|2178973_2180560_+|indolepyruvate-oxidoreductase-subunit-beta-family-protein	unknown	unknown	gnl|CDD|236234
NC_008702.1|WP_011765701.1|2165046_2165901_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|132386

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_008702.1|WP_011765704.1|2167419_2168526_-|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl|CDD|223992	COG1064, AdhP, Zn-dependent alcohol dehydrogenases [General function prediction only].	1.88246e-67
NC_008702.1|WP_011765705.1|2168584_2169613_-|4-hydroxy-2-oxovalerate-aldolase	gnl|CDD|181282	PRK08195, PRK08195, 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated.	0
NC_008702.1|WP_011765717.1|2183638_2185273_+|AMP-binding-protein	gnl|CDD|341257	cd05934, FACL_DitJ_like, Uncharacterized subfamily of fatty acid CoA ligase (FACL). Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Members of this family include DitJ from Pseudomonas and similar proteins.	4.21432e-157
NC_008702.1|WP_011765710.1|2175413_2176190_+|cyclase-family-protein	gnl|CDD|224790	COG1878, COG1878, Kynurenine formamidase [Amino acid transport and metabolism].	9.17027e-62
NC_008702.1|WP_011765708.1|2171447_2172401_-|3-carboxyethylcatechol-2,3-dioxygenase	gnl|CDD|153377	cd07365, MhpB_like, Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate. 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB) catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate, yielding the product 2-hydroxy-6-oxo-nona-2,4-diene 1,9-dicarboxylate. It is an essential enzyme in the beta-phenylpropionic degradation pathway, in which beta-phenylpropionic is first hydrolyzed to produce 2,3-dihydroxyphenylpropionate. The enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. LigAB-like class III enzymes are usually composed of two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. This model represents the catalytic subunit, B. MhpB is likely to be a tetramer.	3.75869e-180
NC_008702.1|WP_011765712.1|2176748_2178953_+|indolepyruvate-ferredoxin-oxidoreductase-subunit-alpha	gnl|CDD|226684	COG4231, COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion].	0
NC_008702.1|WP_011765714.1|2180605_2181583_+|oxidoreductase	gnl|CDD|99782	cd06185, PDR_like, Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur [2Fe-2S] cluster domain. Although structurally homologous to FNR, PDR binds FMN rather than FAD in it's FNR-like domain. Electron transfer between pyrimidines and iron-sulfur clusters (Rieske center [2Fe-2S]) or heme groups is mediated by flavins in respiration, photosynthesis, and oxygenase systems. Type I dioxygenase systems, including the hydroxylate phthalate system, have 2 components, a monomeric reductase consisting of a flavin and a 2Fe-2S center and a multimeric oxygenase. In contrast to other Rieske dioxygenases the ferredoxin like domain is C-, not N-terminal.	1.18213e-89
NC_008702.1|WP_011765706.1|2169627_2170548_-|acetaldehyde-dehydrogenase-(acetylating)	gnl|CDD|236227	PRK08300, PRK08300, acetaldehyde dehydrogenase; Validated.	0
NC_008702.1|WP_011765716.1|2183142_2183625_+|aromatic-ring-hydroxylating-dioxygenase-subunit-beta	gnl|CDD|238357	cd00667, ring_hydroxylating_dioxygenases_beta, Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the substrate by nonheme iron-containing dioxygenases. These enzymes consist of two or three soluble proteins that interact to form an electron-transport chain that transfers electrons from reduced nucleotides (NADH) via flavin and [2Fe-2S] redox centers to a terminal dioxygenase. Aromatic-ring-hydroxylating dioxygenases oxidize aromatic hydrocarbons and related compounds to cis-arene diols. These enzymes utilize a mononuclear non-heme iron center to catalyze the addition of dioxygen to their respective substrates. The active site of these enzymes however is in the alpha sub-unit. No functional role has been attributed to the beta sub-unit except for a structural role.	7.37864e-39
NC_008702.1|WP_011765718.1|2185269_2186448_+|thiolase-family-protein	gnl|CDD|238425	cd00829, SCP-x_thiolase, Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.	1.72019e-90
NC_008702.1|WP_011765694.1|2173723_2175064_-|Rieske-2Fe-2S-domain-containing-protein	gnl|CDD|239617	cd03548, Rieske_RO_Alpha_OMO_CARDO, Rieske non-heme iron oxygenase (RO) family, 2-Oxoquinoline 8-monooxygenase (OMO) and Carbazole 1,9a-dioxygenase (CARDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to tolerate and utilize aromatic compounds for growth. The oxygenase alpha subunit contains an N-terminal Rieske domain with an [2Fe-2S] cluster and a C-terminal catalytic domain with a mononuclear Fe(II) binding site. The Rieske [2Fe-2S] cluster accepts electrons from a reductase or ferredoxin component and transfers them to the mononuclear iron for catalysis. OMO catalyzes the NADH-dependent oxidation of the N-heterocyclic aromatic compound 2-oxoquinoline to 8-hydroxy-2-oxoquinoline, the second step in the bacterial degradation of quinoline. OMO consists of a reductase component (OMR) and an oxygenase component (OMO) that together function to shuttle electrons from the reduced pyridine nucleotide to the active site of OMO, where O2 activation and 2-oxoquinoline hydroxylation occurs. CARDO, which contains oxygenase (CARDO-O), ferredoxin (CARDO-F) and ferredoxin reductase (CARDO-R) components, catalyzes the dihydroxylation at the C1 and C9a positions of carbazole. The oxygenase component of OMO and CARDO contain only alpha subunits arranged in a trimeric structure.	1.85421e-82
NC_008702.1|WP_011765700.1|2164556_2165000_-|lipocalin-like-domain-containing-protein	gnl|CDD|372819	pfam13924, Lipocalin_5, Lipocalin-like domain. This family includes domains distantly related to lipocalins. However, they do contain the important GXW motif in the first strand. The protein in this family include aln5, which is involved in biosynthesis of alnumycin. The family also includes the ZFK protein from Trypanosoma brucei which is a protein kinase. This domain is at the C-terminus of that protein. The domain is also found as the C-terminal domain in StiJ a protein involved in producing stigmatellin. This domain has been assumed to catalyze a final cyclisation reaction.	2.1889e-42
NC_008702.1|WP_011765703.1|2166832_2167366_-|cupin-domain-containing-protein	gnl|CDD|380359	cd02231, cupin_BLL6423-like, Bradyrhizobium japonicum BLL6423 and related proteins, cupin domain. This family includes bacterial and fungal proteins homologous to BLL6423, a Bradyrhizobium japonicum protein of unknown function; it includes a structure of an uncharacterized protein from Novosphingobium aromaticivorans. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	9.49457e-44
NC_008702.1|WP_011765707.1|2170616_2171411_-|fumarylacetoacetate-hydrolase-family-protein	gnl|CDD|183092	PRK11342, mhpD, 2-keto-4-pentenoate hydratase; Provisional.	8.29569e-104
NC_008702.1|WP_011765715.1|2181599_2182922_+|Rieske-2Fe-2S-domain-containing-protein	gnl|CDD|239612	cd03538, Rieske_RO_Alpha_AntDO, Rieske non-heme iron oxygenase (RO) family, Anthranilate 1,2-dioxygenase (AntDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to tolerate and utilize aromatic compounds for growth. The oxygenase alpha subunit contains an N-terminal Rieske domain with an [2Fe-2S] cluster and a C-terminal catalytic domain with a mononuclear Fe(II) binding site. The Rieske [2Fe-2S] cluster accepts electrons from a reductase or ferredoxin component and transfers them to the mononuclear iron for catalysis. AntDO converts anthranilate to catechol, a naturally occurring compound formed through tryptophan degradation and an important intermediate in the metabolism of many N-heterocyclic compounds such as indole, o-nitrobenzoate, carbazole, and quinaldine.	1.97179e-91
NC_008702.1|WP_011765709.1|2172425_2173322_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	8.08027e-26
NC_008702.1|WP_011765702.1|2166073_2166811_+|FCD-domain-containing-protein	gnl|CDD|183181	PRK11534, PRK11534, DNA-binding transcriptional regulator CsiR; Provisional.	2.70707e-41
NC_008702.1|WP_011765713.1|2178973_2180560_+|indolepyruvate-oxidoreductase-subunit-beta-family-protein	gnl|CDD|236234	PRK08312, PRK08312, indolepyruvate oxidoreductase subunit beta family protein.	0
NC_008702.1|WP_011765701.1|2165046_2165901_-|alpha/beta-fold-hydrolase	gnl|CDD|132386	TIGR03343, 2-hydroxy-6-oxo-6-phenylhexa-24-dienoate_hydrolase, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase. Members of this family are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, or HOPD hydrolase, the BphD protein of biphenyl degradation. BphD acts on the product of ring meta-cleavage by BphC. Many species carrying bphC and bphD are capable of degrading polychlorinated biphenyls as well as biphenyl itself.	1.11994e-54

Protein sequences

>NC_008702.1|WP_011765709.1|2172425_2173322_-|alpha/beta-hydrolase
MQTSYQSIWAELRQTSFSQGWTDAGGINTRYLHCGDRAAPALILLHGVGGHAEAYVRNLKSHGRHFSTWAIDMIGHGWTDLATRDLEIPAYIDHLLRFMDAQRIERASFSGESLGGWVAARMAIDHPDRVERLVLNTAGGSQADPVVMERLKTLSLQAATDPSWNFIKARVEWLMADKSKAYDDLIATRQAIYSRPGMAAAMKHNMVLQDMETRLRNLLRAEDYACITAPTLVLWTSHDPTANVAEGRRIASMIPGALFTVMEGCGHWPQFEDAQVFNRIHLAFLLGGHVPEAVAAGG
>NC_008702.1|WP_011765708.1|2171447_2172401_-|3-carboxyethylcatechol-2,3-dioxygenase
MSAMLQCMSHTPLKGYFDPAADVVEEVAALAAAVREEVAHFDPEVVYLFAPDHYNGFFLDLMPQFCLGIEATSVGDYQTPKGPLRVPRALAEACAGAVIARGIDLAFSYRMQVDHGFAQTLVEVLGGLARYPVVPIMINAVAPPLASFQRARLLGAAVGEFARGQGGRALFIASGGMSHNPPIPQIATATDPEVIERIVAGRNPTPEARAARQQRTVAAAQAFAAGDSPLRPLNPDWDRALMKRLCSRDWAAIDAYRNDEVSAAAGASAHELKSWVAATAAMESATAGQWDARERYYRAIPEWLAGFGAMSGLGRHP
>NC_008702.1|WP_011765707.1|2170616_2171411_-|fumarylacetoacetate-hydrolase-family-protein
MPLESPEIAAAAELLHRAASQHQPIAPLREQVADTSVEAAYAIQAHNTARALAAGRRLVGRKIGLTSPAVQRQLGVDQPDFGMLFADMAVGDAEPVARGRLIQPKVEAEIAFVLGHPLERERHTYADILRAIDFCVPAVEIVDSRIADWRISLFDTIADNASSGLFVLGGNPVRPGAFDIGRCAMRMSEGERVVSEGNARACLGNPLNAAVWLADMLVRVGQPLQAGDIVLTGALGPMVAVDPQRPQRFLVDIEGLGHVEACFE
>NC_008702.1|WP_011765706.1|2169627_2170548_-|acetaldehyde-dehydrogenase-(acetylating)
MNKIKCALIGPGNIGTDLLYKLKRSPVLEPVWMVGIDAASEGLARARELGLKTTADGVDGLLPHVKADGVQIAFDATSAYVHAENSRKLNELGVLMIDLTPAAIGPFCVPPVNLKDHVGRGEMNVNMVTCGGQATIPMVAAVSRVQPVKYGEIVATVSSKSAGPGTRKNIDEFTRTTAGAVEKVGGAKVGKAIIILNPAEPPLIMRDTVHCLTETEPDQQKITESIHAMIREVQKYVPGYKLVNGPVFDGNRVSIYLEVEGLGDYLPKYAGNLDIMTAAGARTAEMFAEEILAGRLTLESNRAVLA
>NC_008702.1|WP_011765705.1|2168584_2169613_-|4-hydroxy-2-oxovalerate-aldolase
MDLRGTRITVHDMTLRDGMHPKRHLMTLEQMKTIAQGLDQAGIPLIEVTHGDGLGGSSVNYGFPAHTDEEYLGAVIPLMKQAKVSALLLPGIGTVDHLKMAHELGVNTIRVATHCTEADVSEQHISYARKLGMDTVGFLMMAHMNSPEGLVQQAKLMESYGANCIYVTDSAGHLLPDTVKARISAVRDALKPETELGFHGHHNLAMGVANSIAAIEAGATRIDAAAAGLGAGAGNTPMEVLIAVCDLMGIETGVDVFKIQDVAEDLVVPIMDFPIRIDRDALTLGYAGVYGSFLLFAKRAEKKYGVPAREILVEMGRRGMVGGQEDMIEDTAITLAKASAAA
>NC_008702.1|WP_011765704.1|2167419_2168526_-|alcohol-dehydrogenase-catalytic-domain-containing-protein
MKTMKAARLHEIGGSFAIDEVPVPKPGPQDVLVRVEACGLIPNLRNVVTHFPTWYPFLPLPALPAIFGLDAAGTVAAVGEGVKSVRPGDRVYVNPGLSCGECRYCKQGEPTRCDAYTFMGYFGFGKGSQALFERYPYAGYAEYMTAPVANLVRLPDQVSSAQAARFGYMGTAYSALRKAALQAGQSVLILGATGTLGVGAVLLALGFGAARVVVVGRDRALLDRLLRLDPKRVVPLPLDGQPIHPRVREQVPGGVDAMLDTLGAKAPAELSVDAMQAVARGGRIVQIGGVAGPIPIDPHPFMCAQLQYIGSLWFTAAEGDEMLAMIEAGLVDLSVLEPRPYPLEALNEALEDIQTQANGFTNFHIAHR
>NC_008702.1|WP_011765703.1|2166832_2167366_-|cupin-domain-containing-protein
MTPRRIVTGHDERGRSTILYDSPLQGGAFRHTPGFEVNILWRTPPLPTIAPRADDAGAAIASVLPDAGGTTALLVCFPPDSAPGADFDPAAAGAEFAERLPGLAECFEPDAPGFHRSATIDYGVVIEGEIWLELDDGVTRHLRQGDVIVQRGTRHAWRNRGSKPARLLFTLIGAESG
>NC_008702.1|WP_011765702.1|2166073_2166811_+|FCD-domain-containing-protein
MPLESLLSAVSSASAEPPSTLIEAAYRQIRRDIVLGVHPPGERLRIEQLKTRYAASSGTLREALALLVSDDLVVAQGQRGFSVAPMSLEDLTDLSYVRSLVEAEAARQSLLRGDDDWEARLVSAFHKLTRTEERLAARTADVYEEWELRNFEFHEALVSACGSPRLLSLRAMLHLQAERYRRVSALSGPRPGSVHAEHEQIFTLALARKGDALAEVIGQHVRRSLDVIRNSGLLSARAQDGGEAA
>NC_008702.1|WP_011765701.1|2165046_2165901_-|alpha/beta-fold-hydrolase
MSQNNPELGSSIEIGSVRTNYHDLGKGFPVLMIHGSGPGVSGYVNWRTVMNPLAEKRRVLIPDMLGFGFTERKPDQHYDVDAWVVQAIGLLDALDLPRADIVGNSFGGALALKLAIRHPKRIRRIVLMGSAGLDFPLTEGLDAVWGYEPSPENMRRILDIFAFNRSLITDDLARLRYEASIQPGFQEAFAAMFPPPRQRWVSALASAEDDLRRIPHETLLVHGREDRVIPLASSVTLAGLIPRAQLHVFGRCGHWTQIEQAARFIRLVADFLDEADSAEPRPLD
>NC_008702.1|WP_011765700.1|2164556_2165000_-|lipocalin-like-domain-containing-protein
MTKGIEGRWEIVSWRQEYDDGRCVYPFGETLEGFIDYSRDSDAMFCVLSRKPRTAFTTGGQWDAADADKARAYDEYLTYAGRYSFDGEQVTHHIQQCIFPNWQGTAQRRKVVRTSDDEITLVARIEEGTSEARTAILAWRRAAGGRA
>NC_008702.1|WP_011765694.1|2173723_2175064_-|Rieske-2Fe-2S-domain-containing-protein
MSDEPVIRRRTVAQGHAISEARVNNTRTQSQYQPYKDAAWGFINHWYPAVFSKELAEDEVKGIQICGIPIVLRRVDGKVYALKDQCLHRGVRLSEKPMCFNKKTISCWYHGFTFDLKDGRLSTIVANPDDKLVGTTGITSYPTEEVAGMVFVFVREDGFPDSDVPPLADDLPFRFPENSERFPHPLWPAAPSLLDDNAVALGMHRTGYGNWRIACENGFDNAHILVHKDNTIVHAMDWVLPLGILPTSDDCITVVEDEKGPKGMMQWLFTDRWAPVLENKELGLKVEGLNGRFYRTSVVLPGVLMVENWPGEHIVQYEWYVPITDDLHEYWEVLVKVCPDEKARADFDYKFERVYKPLCLHGFNDCDLYAREAMQNFYADGTGWDDEQLVATDISPITWRKLASRWNRGIAKPGKGVAGAVKTHSIRFKETAAGKPPGYFVEQIED
>NC_008702.1|WP_011765710.1|2175413_2176190_+|cyclase-family-protein
MSSLASFVTDLASGRIRVVDLTQTLKPEFPTIPLPPQFGQCAPFTIEEVSRYDDRGPAWYWNNFACNEHTGTHFDAPIHWVTGKDLPNNAVDTIPAEHFIAPACVIDCSAEVAANPDFLLTVGFVQAWEEKHGRIPPRAWVLMRTDWSRQPTPEAYLNAREDGMHTPGPDAGVVQWLIEARDVCGFGVEAIGTDAGQSFKWEIPFPCHYYMHGNNRYGLQCLTNLDQLPPQGAVILAAPLKIRNGSGSPLRVLALVES
>NC_008702.1|WP_148268737.1|2176399_2176657_-|hypothetical-protein
MGQIEVGHVFLLRLVPRAAPDVLQRKRIGTGIYVVITTLGMNISAVNGKDEISWMTKNTMKNQTGSLFIVVRTCTIQVPEKSLSA
>NC_008702.1|WP_011765712.1|2176748_2178953_+|indolepyruvate-ferredoxin-oxidoreductase-subunit-alpha
MAERSFKKEVQQLRIPAGQEFRGEGILAITKALLQSGVGYVGGYQGSPISHLMDVLADANEILQELDVHFETSASEATAAAMLAASVMYPIRGAVTWKSTVGTNVASDALANLASGGVTGGALIIIGEDYGEGSSIMQERSHAFAMKSQMWLLDPRPNLESIVQSVEDGFELSEASNTPVMLQVRIRSCHVHGRFITKENKRPRYTLKQALENPVRDTSRIVLPPASFAHEHEKIQQRWPAAVKFIREKKLNEFFDGDFKDIGLILQGGLYNGVIRALQLLGLADSYGNSRIPMYVMNVTYPVIDEEVVQFCEGKRAVLMLEEGQPDYIEQNLHAILRKAGVATHLSGKDVLPMAGEYTTAAMRAGIEAFLKAHQPDALATHEAVAADEVAEAAVAPVPKAKPAAVPITFHPKVKALADVVPPRPAGFCVGCPERPIFAAMKLAQADLGEHHVSCDIGCHLFSILPPFNLGATTMGYGLGAASSSAFNVKTGKRSISVMGDGGFWHNGLTSGIANAVFNKNDGVIVIVDNYYSSATGGQDIPSSRADNPDRSTKNPIEAAIKGAGVKWVRTIDRTYDVARMRDTLEEALTTTTDGPKVIIAQSECMLNRQRREKPIFTKKVKAGERAVKERFGVDPDVCTGDHACIRLSGCPSLSVKDSGDPLKEDPVAHVDSGCVGCGNCGEVAEAAVLCPSFYRADIIHNPTGGDRFIAKIRSAVIGWLQRRRAARLAQYAL
>NC_008702.1|WP_011765713.1|2178973_2180560_+|indolepyruvate-oxidoreductase-subunit-beta-family-protein
MSNIVLHPGTPIKIAILAMGGQGGGVLADWIVEMAEHAGWWAQTTSVPGVAQRTGATIYYLELLPEAAAKAAGKPPTLAMMPTPGDVDLVVAAELMEAGRAMQRGLVAPDRTTLITSTHRSYSVTEKAALGNGIGDPNKVLDAGREAAKRVLAFDLQALAEKAGSVISASLFGAIAGSGALPFGREAFEETIRSSGKGVEPSLRAFALGFEAASKAPEVPAAIDTSRPAPVVPDRVANPEVQKLLDKVKAEFPPVAHGMLVAGLRRLIDYQDVAYAAEYLQKCGELRALDERNGGEAKGWALTQAAAHRVAVAMSYDDVIRVADLKTRGSRFERVKKEVGAKADQLVYTTEFMHPRLEEICGTLPAGLGRWLENSKGIGGFVKRKMEHGRRVRTGTLTWFLALYALAGMRRFRRSLLRHQIETAQQKDWLERVVRLVGKGDYDLAVETLHCRRIVKGYSGTHDRGDKRFAALMKAADELAGRPQAAVTLHQLLEAAMADEQGRQLDAQLGMLLKGNLTAGNQLARQAA
>NC_008702.1|WP_011765714.1|2180605_2181583_+|oxidoreductase
MPELELTISAIEAETPLIRTLHLRAPAGSSLPAFTPGAHLQVSVPGLADARCYSLVSFDADPAAFEAPLAYRLGVRLEDASRGGSRYMHGLAVGDTVKVSGPKNDFPLHAAEAGERPIVLIAGGIGITPIAAMAASLQASGRAFELHYSGRSRDQLAFVDELAALAGNAFFVHADDDPASRLDLGALLDGLDTAQHLYVCGPKGMIDALIEGANTRGWPSERVHFELFAAAAPVAGDQAFEVELAQSGKVLLIPADKTILDVMEAEGCDPMYDCKRGECGVCTATVLEGVPDHRDYFLSDAEKAGGKLIQICISRAKTPRLVLDL
>NC_008702.1|WP_011765715.1|2181599_2182922_+|Rieske-2Fe-2S-domain-containing-protein
MSTTNTYRGNPDAIRALVRDTEVHKDTYIDQELFELEMEHLFANTWVYVGHASQVPNKGDYYTTTVGTEPVVMVRHTDDSIRVLYNRCPHKGVKVAGEVCGNTGKFFRCPYHAWTFKTDGSLLAIPLKKGYENTGFENCEASQGMAPVKNVKVYRDFVFCRLNPGGPSFEEYFGESLSTIDNMVDRSPEGKLEVAGGVLRYMHNCNWKMLVDNQTDTCHPMVAHESSAGTAVRVWNEAPEGTPKPMAVELFAPFMSPYEFFEGMGIRVWENGHGHTGVSNSIHAAYSAIPGYWEQMVAAYGEDRAHQILGDVRHNTVYWPNIMIKGPIQTLRLFKPIAADKTLVESWTFRLVGAPDMLLERTTMYNRLINAPTSVVGHDDLEMYERAQEGLHARGRDWINVGRLYDPAEKDQKNVVTNGTNEMQMRAQFRAWLKYMTESM
>NC_008702.1|WP_011765716.1|2183142_2183625_+|aromatic-ring-hydroxylating-dioxygenase-subunit-beta
MTAITEKTLTDFVYAEARMLDEQRFNDWLALFTDDAYYWMPLAHDQQDPKLHTSLLYEDTLLLRVRIERLNGQRTFSQQPKSRCHHLLQAPSIEAFDADKGEYTVRTAFHYTETRQDKQTLYAGWATHQLVAVDGVLKIRQKRVDLVNCDAAFGNIQLFM
>NC_008702.1|WP_011765717.1|2183638_2185273_+|AMP-binding-protein
MANTVHQAFSLAAVRWAKQPFLCILPETAQIYGIAAGELRYAEAAERIEFLRAAYAAAGYGHGHRVGILLENRPGFFLHWFALNALGVSVVPINPDMRAAELEYLIGHSEIALAVALPHRHDDLIAAADKAGRPFKVMAERDLPPAAAFPAPLADTAPHELTECALLYTSGTTGRPKGCILPNRYFLHAGKWYSEIGGLAALQPGRERMITPLPLVHMNAMAYSAMAMVMTGGCLIPLDRFHPRSWWASVRESRATVVHYLGVMPAMLMKAEPTVADREHSVRFGFGAGVDRTLHGIFEERFGFPLLEAWAMTETGAGAVVIANKEPRHIGSSCFGKEEADVLVRIVKDDGTEAGAEEQGELLVRHAGEDPRYGFLAGYLKDPAATDEAWAGGWFHTGDIVRRDADGYLHFVDRKKNVIRRSGENIAAVEVEAVLQQHPLVKSVAVAAVPDAVRGDEVMALVVAQDWPADRAAMEAAAADVVNWTLSQLAYYKAPGYVAFVPALPLTTTNKIQRGELKALAPTLVDSPNCVNTCAMKKRQGDHK
>NC_008702.1|WP_011765718.1|2185269_2186448_+|thiolase-family-protein
MSTRKRQGYDGVVAVLPVTIPYARYSTRSAHWWLGRALGELVRGSGLAKAQIDGVCVSSFTLGPDTAVGLMQHLGMSPRWLDHIPMGGASGVVALRRAARAVQAGDAEVIACIAGDTNAVDSFRNTVSQFSRFAQDAVYPYGAGGPNASFALLTDYYMRHYGATREDFGKLCVAQRDNALKNPHALMKKPLTLAQYMEARAITDPIHLFDCVMPCAGAEGYLVMTEDRARALKLPFVRIRSTIERHNAFPEDPIQFRGGWAMDKDALYEHAGIAPADVDFLETYDDYPVINMMQFEDLGFCAKGEAPAFVREHSFTIEGSFPFNTSGGQLSVGQAGAAGGYLGFVQALRQLTGGAGHTQVKDAKIGMVSGFGMINYDRGLCSGAAVLERGQA

Crispr_ID: NC_008702_3

• CRISPR_ID: NC_008702_3
• CRISPR_location: 2239830-2239922
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_008702_3

Consensus_repeat	Method
ATCCACGCTGAACAACTCCCGGCG	CRISPRCasFinder

spacers of NC_008702_3

>3.1|2239854|45|NC_008702|CRISPRCasFinder
GGCCTTGCCTTGAAAATCATCGCCTTAACGGCACAAGCCCAACTT

CRISPR arrays and Neighbor proteins around NC_008702_3

CRISPR arrays

The CRISPR arrays of NC_008702_3

>merge|NC_008702|3|2239830-2239922|CRISPRCasFinder
ATCCACGCTGAACAACTCCCGGCGGGCCTTGCCTTGAAAATCATCGCCTTAACGGCACAAGCCCAACTTATCCACGCTGAACAACTCCCGCCG

>NC_008702|3|3|2239830-2239922|CRISPRCasFinder
ATCCACGCTGAACAACTCCCGGCG	GGCCTTGCCTTGAAAATCATCGCCTTAACGGCACAAGCCCAACTT
ATCCACGCTGAACAACTCCCGCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_008702.1|WP_011765768.1|2236134_2236755_-|DUF3275-family-protein	unknown	unknown	gnl|CDD|371666
NC_008702.1|WP_011765769.1|2237095_2237575_-|DUF3577-domain-containing-protein	unknown	unknown	gnl|CDD|371899
NC_008702.1|WP_011765779.1|2247593_2248190_+|hypothetical-protein	unknown	unknown	unknown
NC_008702.1|WP_011765778.1|2246567_2247158_+|DNA-repair-protein-RadC	unknown	unknown	gnl|CDD|178801
NC_008702.1|WP_041642529.1|2248186_2248480_+|DUF4031-domain-containing-protein	unknown	unknown	gnl|CDD|379076
NC_008702.1|WP_083831934.1|2239086_2239623_+|hypothetical-protein	unknown	unknown	gnl|CDD|309782
NC_008702.1|WP_148268740.1|2238230_2238542_+|hypothetical-protein	unknown	unknown	unknown
NC_008702.1|WP_148268739.1|2233721_2234228_-|hypothetical-protein	unknown	unknown	unknown
NC_008702.1|WP_011765765.1|2232807_2233167_-|IS66-family-insertion-sequence-element-accessory-protein-TnpB	unknown	unknown	gnl|CDD|377551
NC_008702.1|WP_011765777.1|2244048_2246235_+|DUF262-domain-containing-protein	unknown	unknown	gnl|CDD|377008
NC_008702.1|WP_011765767.1|2234649_2235642_-|SAM-dependent-methyltransferase	unknown	unknown	unknown
NC_008702.1|WP_011765774.1|2240701_2241337_+|hypothetical-protein	unknown	unknown	unknown
NC_008702.1|WP_011765763.1|2231720_2232221_+|hypothetical-protein	unknown	unknown	unknown
NC_008702.1|WP_011765781.1|2249015_2250140_-|ISAs1-like-element-ISAzo8-family-transposase	unknown	unknown	gnl|CDD|379382
NC_008702.1|WP_011765782.1|2250270_2251566_-|integrase-family-protein	unknown	unknown	gnl|CDD|271182
NC_008702.1|WP_011765766.1|2233166_2233475_-|IS66-family-insertion-sequence-hypothetical-protein	unknown	unknown	unknown
NC_008702.1|WP_011765771.1|2238648_2239074_+|replicase-RepA	unknown	unknown	gnl|CDD|309782
NC_008702.1|WP_011765780.1|2248682_2248952_+|AlpA-family-phage-regulatory-protein	unknown	unknown	gnl|CDD|225848
NC_008702.1|WP_148268741.1|2251814_2254355_+|DNA-mismatch-repair-protein-MutS	unknown	unknown	gnl|CDD|235444
NC_008702.1|WP_011765776.1|2242276_2244052_+|DUF262-domain-containing-protein	unknown	unknown	gnl|CDD|377008

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_008702.1|WP_011765768.1|2236134_2236755_-|DUF3275-family-protein	gnl|CDD|371666	pfam11679, DUF3275, Protein of unknown function (DUF3275). This family of proteins with unknown function appear to be restricted to Proteobacteria.	5.4082e-48
NC_008702.1|WP_011765769.1|2237095_2237575_-|DUF3577-domain-containing-protein	gnl|CDD|371899	pfam12101, DUF3577, Protein of unknown function (DUF3577). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 143 to 307 amino acids in length.	5.15075e-63
NC_008702.1|WP_011765778.1|2246567_2247158_+|DNA-repair-protein-RadC	gnl|CDD|178801	PRK00024, PRK00024, DNA repair protein RadC.	3.09931e-61
NC_008702.1|WP_041642529.1|2248186_2248480_+|DUF4031-domain-containing-protein	gnl|CDD|379076	pfam13223, DUF4031, Protein of unknown function (DUF4031). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 91 and 130 amino acids in length. There is a conserved HYD sequence motif.	7.58038e-16
NC_008702.1|WP_083831934.1|2239086_2239623_+|hypothetical-protein	gnl|CDD|309782	pfam04796, RepA_C, Plasmid encoded RepA protein. Family of plasmid encoded proteins involved in plasmid replication. The role of RepA in the replication process is not clearly understood.	3.73087e-13
NC_008702.1|WP_011765765.1|2232807_2233167_-|IS66-family-insertion-sequence-element-accessory-protein-TnpB	gnl|CDD|377551	pfam05717, TnpB_IS66, IS66 Orf2 like protein. This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition.	3.33737e-40
NC_008702.1|WP_011765777.1|2244048_2246235_+|DUF262-domain-containing-protein	gnl|CDD|377008	pfam03235, DUF262, Protein of unknown function DUF262.	1.64689e-18
NC_008702.1|WP_011765776.1|2242276_2244052_+|DUF262-domain-containing-protein	gnl|CDD|377008	pfam03235, DUF262, Protein of unknown function DUF262.	5.29442e-26
NC_008702.1|WP_011765781.1|2249015_2250140_-|ISAs1-like-element-ISAzo8-family-transposase	gnl|CDD|379382	pfam13808, DDE_Tnp_1_assoc, DDE_Tnp_1-associated. This domain is frequently found N-terminal to the transposase, IS family DDE_Tnp_1, pfam01609 and its relatives.	1.09624e-37
NC_008702.1|WP_011765782.1|2250270_2251566_-|integrase-family-protein	gnl|CDD|271182	cd00801, INT_P4_C, Bacteriophage P4 integrase, C-terminal catalytic domain. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. The P4 integrase mediates integrative and excisive site-specific recombination between two sites, called attachment sites, located on the phage genome and the bacterial chromosome. The phage attachment site is often found adjacent to the integrase gene, while the host attachment sites are typically situated near tRNA genes. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.94243e-29
NC_008702.1|WP_011765771.1|2238648_2239074_+|replicase-RepA	gnl|CDD|309782	pfam04796, RepA_C, Plasmid encoded RepA protein. Family of plasmid encoded proteins involved in plasmid replication. The role of RepA in the replication process is not clearly understood.	9.9788e-06
NC_008702.1|WP_011765780.1|2248682_2248952_+|AlpA-family-phage-regulatory-protein	gnl|CDD|225848	COG3311, AlpA, Predicted transcriptional regulator [Transcription].	2.1248e-11
NC_008702.1|WP_148268741.1|2251814_2254355_+|DNA-mismatch-repair-protein-MutS	gnl|CDD|235444	PRK05399, PRK05399, DNA mismatch repair protein MutS; Provisional.	0

Protein sequences

>NC_008702.1|WP_083831934.1|2239086_2239623_+|hypothetical-protein
MFGSLITAHYTGNQQHRGFVLKNVLIAEDLQLNDAELTGLWTPQQAHEAGRWQSQVRLSHGFFRECIENPVPIDLRAYKALRGSPLAMDVYTWLTYRMSYTHRRSRPIRWEPLMMQFGCDYGTETGQAVRDFRKAFLKALKLVLVVYPQAQIEVGDTGLLLLPSRHHVPPTPTQGLLF
>NC_008702.1|WP_011765771.1|2238648_2239074_+|replicase-RepA
MPTSKPTQLKLDYRSGQPIPAWVREVIDAHLAIETEDARSAGALGFMARALVIATMPYKDPKTDVFKRQNGDFRLRIIAGYEGGIPYGIYPRLLMSWVSTEAVRTRSPVIQLGDSLRAFLRDVMDLRSTGGGVRGSGTRVA
>NC_008702.1|WP_148268740.1|2238230_2238542_+|hypothetical-protein
MTNVMHLNTHPARLRPGDMAIHQEHGWVEILARAGAQRKIRWTEYATLAAEALAPDELCGELLTVWEDWVDGDTLKAGSARPIPHRLRRGTGLAPLREPSADQ
>NC_008702.1|WP_011765769.1|2237095_2237575_-|DUF3577-domain-containing-protein
MSNQAHSKAAAPEKEYFDLHTQGCGYLSRIRWVNPRKSAGRQGKPFLACAINALHGDTTDPSYSYFDVRVTEQDCVELVQSLQSDVDAGRKVFVAFKIGDIYPHSYTIEVKDKASGQVTQEARAIIKGRLFLLSHVKVDGETIYERPPQRVEPRSSTDG
>NC_008702.1|WP_011765768.1|2236134_2236755_-|DUF3275-family-protein
MSVTVEGSLRIKRIQGANGPFCVGDLLTEIGEFRVKDPVLDQFEEGVYTGRYIIQRIFSWSYTSNGRLVVEIRARLADLQIDDGTESTVPDAPAEPDPADEQSQPAEEGAESPAVAREDDKPAETASAPVADASPDRRLFGDELYALVVERKPVKLDPAIDDRKRFREQRNRLKSGLDYAFVPEEQTWYPAESEQYQAYLAGKSEA
>NC_008702.1|WP_011765767.1|2234649_2235642_-|SAM-dependent-methyltransferase
MALIFPRLARNFIKNGYFPTDEATLGRIIAALDIAGDHLRICDPCCGEGAALYAIKNALIACGATVQALGVEFDAERAWHAKTVLDVAIHSDTQDVIVGPRTMGLLFLNPPYADAVPDRAQTGDKPKADRLEKLFVRRTFQCLAYGGVLVLIVPYYVLDAELAGLLTRNFERVQCFMAPEQQYKQCVVFGVRRRSDRPDPAVASQLMAAGKGDFLDCVLPEAWPDEPYVVPAVAPGEFRFHALRIDAAQLAAEVARLHAHSLWPQFATHFGECRGEHRRPLREMGRWHLALAFAELCEAYIGPCECEGSDEKRYNPKWECIASWGIRRND
>NC_008702.1|WP_148268739.1|2233721_2234228_-|hypothetical-protein
MFSKSIFFISMILPFEIGCAAQNDSNSQLVWIFCAGEKIFVHEKKPHSFNVIYGVNFNAGTADEYHSWERGGKKPYKLFFNGERPWYFLQTFKGGVSGPDNTMNWSFDGAFGPTSATLDRERGTMVVQIKDREFDFDGQGKWRIFSDFRGECLKIDPPVDPPVGAKKF
>NC_008702.1|WP_011765766.1|2233166_2233475_-|IS66-family-insertion-sequence-hypothetical-protein
MAIEVKGKWRRRSRAQWRAVLERFGAGGLGVVAFCEREGISVSSFRRWRNVLADAAPGAPDSDHPDEPGGFVDAGVLGPSGAGRPELRLDLGRGVVLHLVRG
>NC_008702.1|WP_011765765.1|2232807_2233167_-|IS66-family-insertion-sequence-element-accessory-protein-TnpB
MFFPEGAVRVQVYGRPFDIRKTFDGLYALIRQAFGCDPLSGDLFVFINRRGSQMKVLYWDRTGFCVWAKRLEQGRFVSDWAQVRTRQMDWTGLKLLLEGVEPARFRRRFNLPENALQAA
>NC_008702.1|WP_011765763.1|2231720_2232221_+|hypothetical-protein
MNAALIEALNRATSLELFHLSTILERLMSDPARIIEIRRHLHLGQSVRFLDWQQAGAQMSLRTGRIVAMKDTQLTVQDERTRREWKLPYAAIEIPEAGSIPAPSVPEPMSPTRADFQVGDRVSFEDRHLQTRAGTIVRINQRTATLDCDGHSWRVSFPLLRHLVDL
>NC_008702.1|WP_011765774.1|2240701_2241337_+|hypothetical-protein
MKPAYSMIAVFSACVSSTHADVLDGVIFGVKCIGAADRAACEARSRREADETRERMRHQPEARVGQSSARTSSADEETIGKRLYRNWMENIVCRDFAKRSPRDVDSTYARAMRHYNFMTPKQIVLQPLTTEAGLQTAGYLHEATPGALYRLEQVVHSPDVANGRRQYKLILDIGRDGSGTHVSGRYCVTTDDPAGWQDLLPQVRASLNNVF
>NC_008702.1|WP_011765776.1|2242276_2244052_+|DUF262-domain-containing-protein
MSTGDLQLRSVSELMTESFFIPAYQRGYRWTSRQVTELLDDVAAFTLRPRPVQGDFYCLQPIVVTQRGDQWELIDGQQRLTTIFLVLSFFNNRLVEDERSELFSLSYETRANSAAYLKSLDEKARDDNIDFFHIWQAYQTIREWFKTRINRLNYIQGAFLNEVKVIWYEVDHLVGPIDVFTRLNVGKIALTNSELVKALFLKGSNFDGDGSRAKQLQQLRIAQDWDEIERRLQEPGFWYFVTNRQQEANRIELVLQLRAEELGRAATPWDINSMFLAFNAHLAEKHDDVPNEWDAVKRIFLQLDEWYRDRFLYHVVGFLLSQDVKVAQIRDLARKSGSKTTFRAALIEEVFRITLGADTADTGLASFVKDRVAGFDYESHGTSIRRLLLLFNIAALLELGDSGPWFPFDHFKREQWDLEHIRSVKSDMPQRVDAQKAWLGQAIEYFSEPEVAAAGRVDDSSDQALPERLRSLREQEPFDSVAFEAAFNDVIDRYDPGSNVEADHSVGNLTLLDAGTNRSYGNAIFPMKRRRIIALDKAGRFVPPCTKNAFLKYYSSKVDEMLVWTQTDAKEHQDSLVTTLVSFFEKHGAAA
>NC_008702.1|WP_011765777.1|2244048_2246235_+|DUF262-domain-containing-protein
MSQARQHSFATLFSAVDAVEIPIIQRDYAQGRKQSADVLDAFLTSLHGALQGEPGQALDLDFIYGTFEDEGSKVLSLLDGQQRLTTLFLLHWYVAMCEGQLEDFRARWTKRGRSRFTYATRPSSLEFFDALANAVLHPPAGGSGWSGKLSAVLIDSNWFFLSWRNDPTVKACMATLDAIVSGFGITKDLYPRLIDEERPPVTFHFLDLERFGLTDDLYIKMNARGKPLTPFENFKAWLVGRVTNEPWAKGFDLALDQKWMDLFWRLAPKQNSAAVASAVDDLYLRFMYVMAFFDACIRLERGYSAPRAAVDWLQKLRHARGYIPLRALEAQGAFAGSAIQVASVVLDHLSGPAFEADIKTLERALAPTSDYADLVRLFSVVAWANSGAVKSNTPNLEAERSRWDRVISNLLANHRIDEVYTASTTIRGVQALASHAGALYDALSRAEAIPGFGAEQAKEEIRKARLIVEDPTRESLFIEAESHPYLQGRIGFLLDFSSAPEEPFDRDAFVRYSQRARAVLDDGLRASAEHLLERAMLSIEDYLIERGGSKFSFCSADGGTYRERSENWFRVIGRSAFKVLLDGVDGDAHSSLLALIGAATCTDWRRYVIAEPRLIDYCKERLIHRDVLGNIYLVSRKRLSGYHVELRSYALYWALQARPREVLPGLGYRYEETYDETPPGLIVQIDAQDLRIAYGSGSWSCSGPSGQVPFPVALVEFMESCGFTEPKA
>NC_008702.1|WP_011765778.1|2246567_2247158_+|DNA-repair-protein-RadC
MSSFYSSPTALADAALLERFFGPEAEDVWEGCDGSWSKVVELAREPRTPAWDALACAIEILHRSFAEQLSARNVLDSPGVVRQFLRTFFEGKPYEIFVVLYLDAQNRLIRAEEAFRGTLTQTSVYPREILRRSLELHAAGVIFSHQHPSGVCEPSSADEVLTNMLKSALTLVDVRVLDHIVVAGDRAVSFAETGRL
>NC_008702.1|WP_011765779.1|2247593_2248190_+|hypothetical-protein
MKPYPTGSRTGRRPLSPADNPAWPGASAEAIRRATHYIRIEDIAHALANACCIQGQTKAFYSVAQHNYLASMLVPPQDALAALLLHTDETLERLLPEYLEIEGHSAAEVLARFGAPATPPLSVECADLVLRATEQRDLGPSSDATKNESAGVPPLTLKIQPLPPIVAKHLFLDRYYELRPEADAERLRHMEAKRRAAK
>NC_008702.1|WP_041642529.1|2248186_2248480_+|DUF4031-domain-containing-protein
MTVYVDALGLNGWQLHGRPVQSCHMFCDGEDHEELHAIAQTIGLKRAWLRSGGGRPHYHLTPGKRVLAIAAGAVPVGRSLAVRIWRTQQTRIRENRP
>NC_008702.1|WP_011765780.1|2248682_2248952_+|AlpA-family-phage-regulatory-protein
MTKTVHAPLKRIFLDLPAVAEVVALSESTVQELVRLGQFPLPRQTSGRRVGWLVREVEEWAESRPASTLPPPANTGAKKARRATTQPRA
>NC_008702.1|WP_011765781.1|2249015_2250140_-|ISAs1-like-element-ISAzo8-family-transposase
MQTREVMPLTQVFVSISDPRSARRVRHDLSELLTVAVCAVLCSADEFSDIEAWAKERIDWLRGFLVLEHGIPSHDTFGRVFAALNPREFEAAFRRWVGQLVPALGPDAVVAIDGKTSRRSTTKAAANPLHLVSAFAADVGLVLGQTATAEKSNEITAIPELLATLALQGCVVTIDAMGTQTGIAKAIRDGGADYVLCVKDNHPKLVESFLLAQAGVGGPLRPSSTSESCEDGHGRTEVRRCWAFDAVDRLYKAEQWPDLKSFAIVECERTVGTKTSCERRYYISSLPAEATRIAHAVRSHWEVENRLHWCLDVLFNEDQSTVRTGFAANNLAIVRHIVMNLLRLNTSRKGSIKTKRMLAATSDTFRAELLGFMT
>NC_008702.1|WP_011765782.1|2250270_2251566_-|integrase-family-protein
MTFDARALKVLPVGEHLTSPDFPGLRLVATSRGKAWIYRYKSPVDGRMRQTKVGQWPAMSVHAAVAEWERLREARGAGADAAVALREERERARQTAALEREAAKRGYTVAKVCDDYFLGYVRLARARKGANEVRRMFDKMLGATAGVLAASLTRAQAFDLINGYAATAPVQAKKLRAELGAAWDYAIDAGRLPDNTPNWWRQILRGKIRSKGKKIAGESVGLAKRVLSSDEVGVLIRWLPNFTALVEDVLTLYLWTGARGSEICAMRGDEVTREADGLWWWTVPKVKTKNARHDGATDLRVPLFGRAVNAVLRRKERFGDSYLFPARTRVLRPVEQKTIQVAVHYHQPYSRTTPRHDRPRLPVTRWGAHDLRRTARTLLASLGCPDAVGEAILGHTPAGILGIYNRHTYDRERVEWLKRLSDHLEDLARLR
>NC_008702.1|WP_148268741.1|2251814_2254355_+|DNA-mismatch-repair-protein-MutS
MMQQYLRIKEQHPDTLLFYRMGDFYELFFEDAEKAARLLDITLTTRGQSAGMPIRMAGVPFHAVEQYLARLVKLGESVVIAEQVGEPGATKGPMERAVSRIVTPGTLTDAALLDDRRDALLLAANMHRGVLGMAWLNLANGEFRLMECPAESLQAQFERLRPAEVLIPDGLALPLMETLAPALRRLADWQFDADTAHRLLTTHFGTRDLAGFGVEEAPVALGAAAALYDYAKATQRQSLAHLTGLRLEREAEFLRLDAATRRNLELTETLRGEPSPTLLSLLDTCMTSMGSRWLRHALHHPLRDRTIPAARQQAVAALVGDGDGLHAQAVRGALRGVADVDRITGRIALRNARPRDLSALRESLSRLPELRQTLAQIGDEGMVGGLAAALDVQPELLQCLQRAIADEPAAMVRDGGVIAAGYDAELDELRGIQTNCGEFLMALEARERERSGIANLKVEFNKVHGFYIEVSHANADKVPDDYRRRQTLKNVERYITPELKAFEDKALSAQERALAREKALYEALLDALSPYIPALQGCARALATLDGLAAFAEAALRYGYVRPVFSDQPGIEIRGGRHPVVERQVEDFIQNDARLGSTRRMLMITGPNMGGKSTFMRQVALICLLAHVGSFVPAQSAVLGPLDAIFTRIGASDDLASGRSTFMVEMTEASAILHGATEHSLVLMDEIGRGTSTFDGLALAFAIARHLLEKNRSLTLFATHYFELTRLNGEYPECANVHLDAVEHGHRIVFLHALEDGPASQSYGIEVAALAGIPAPVIRDAKRRLRALENREVGAGPQADLFAALPDDDDAPLSHPVLIALAEIDPDSLSPREALERLYALKRLSA

Crispr_ID: NC_008702_4

• CRISPR_ID: NC_008702_4
• CRISPR_location: 3392292-3392393
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: WYL

Consensus repeat of NC_008702_4

Consensus_repeat	Method
AGGTTTTGTCCCCTCCCCTTCAAGG	CRISPRCasFinder

spacers of NC_008702_4

>4.1|3392317|52|NC_008702|CRISPRCasFinder
CGTTGGGGGGAAGCAGGTTTTGTCCCCTCCCCTTCAAAGCGTGCGGGGAAGC

CRISPR arrays and Neighbor proteins around NC_008702_4

CRISPR arrays

The CRISPR arrays of NC_008702_4

>merge|NC_008702|4|3392292-3392393|CRISPRCasFinder
AGGTTTTGTCCCCTCCCCTTCAAGGCGTTGGGGGGAAGCAGGTTTTGTCCCCTCCCCTTCAAAGCGTGCGGGGAAGCAGGTTTTGTCCCCTCCCCTTCAAGG

>NC_008702|4|4|3392292-3392393|CRISPRCasFinder
AGGTTTTGTCCCCTCCCCTTCAAGG	CGTTGGGGGGAAGCAGGTTTTGTCCCCTCCCCTTCAAAGCGTGCGGGGAAGC
AGGTTTTGTCCCCTCCCCTTCAAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_008702.1|WP_011766801.1|3387068_3387359_+|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NC_008702.1|WP_011766814.1|3396486_3397866_+|cbb3-type-cytochrome-c-oxidase-subunit-I	unknown	unknown	gnl|CDD|225795
NC_008702.1|WP_011766803.1|3387663_3388353_-|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl|CDD|225253
NC_008702.1|WP_011766809.1|3393104_3393806_+|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223736
NC_008702.1|WP_173364479.1|3398150_3398933_-|NAD-binding-protein	unknown	unknown	gnl|CDD|223643
NC_008702.1|WP_011766812.1|3395347_3395812_-|hemerythrin-domain-containing-protein	unknown	unknown	gnl|CDD|376622
NC_008702.1|WP_011766815.1|3397937_3398141_+|DUF3079-domain-containing-protein	unknown	unknown	gnl|CDD|337966
NC_008702.1|WP_011766804.1|3388507_3388876_+|VOC-family-protein	unknown	unknown	gnl|CDD|225861
NC_008702.1|WP_011766810.1|3393824_3395108_-|hypothetical-protein	unknown	unknown	unknown
NC_008702.1|WP_011766805.1|3389558_3389756_+|hypothetical-protein	unknown	unknown	unknown
NC_008702.1|WP_011766813.1|3396032_3396458_+|cytochrome-c	unknown	unknown	gnl|CDD|365823
NC_008702.1|WP_011766806.1|3389851_3391024_-|isovaleryl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173845
NC_008702.1|WP_011766808.1|3392618_3393011_-|SirB2-family-protein	unknown	unknown	gnl|CDD|377264
NC_008702.1|WP_011766799.1|3384761_3385667_-|hypothetical-protein	unknown	unknown	unknown
NC_008702.1|WP_041642730.1|3391164_3392256_+|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|378890
NC_008702.1|WP_011766800.1|3385766_3386345_-|hypothetical-protein	unknown	unknown	unknown
NC_008702.1|WP_158309411.1|3383306_3384653_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NC_008702.1|WP_011766811.1|3395118_3395355_-|DUF2249-domain-containing-protein	unknown	unknown	gnl|CDD|370777
NC_008702.1|WP_011766802.1|3387355_3387649_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl|CDD|368240
NC_008702.1|WP_011766817.1|3398832_3400161_-|ATPase	unknown	unknown	gnl|CDD|273349

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_008702.1|WP_011766803.1|3387663_3388353_-|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	2.1e-66	219.3	0.1

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_008702.1|WP_011766814.1|3396486_3397866_+|cbb3-type-cytochrome-c-oxidase-subunit-I	gnl|CDD|225795	COG3256, NorB, Nitric oxide reductase large subunit [Inorganic ion transport and metabolism].	1.21751e-161
NC_008702.1|WP_011766803.1|3387663_3388353_-|YafY-family-transcriptional-regulator	gnl|CDD|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	8.16352e-64
NC_008702.1|WP_011766809.1|3393104_3393806_+|Crp/Fnr-family-transcriptional-regulator	gnl|CDD|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	5.3263e-41
NC_008702.1|WP_173364479.1|3398150_3398933_-|NAD-binding-protein	gnl|CDD|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	2.08497e-50
NC_008702.1|WP_011766812.1|3395347_3395812_-|hemerythrin-domain-containing-protein	gnl|CDD|376622	pfam01814, Hemerythrin, Hemerythrin HHE cation binding domain. Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor hemerythrin binds Cadmium so as to protect the organism from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial NorA is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus the iron-sulfur cluster repair protein ScdA has been noted to be important when the organism switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger.	1.12037e-13
NC_008702.1|WP_011766804.1|3388507_3388876_+|VOC-family-protein	gnl|CDD|225861	COG3324, COG3324, Predicted enzyme related to lactoylglutathione lyase [General function prediction only].	2.03253e-34
NC_008702.1|WP_011766813.1|3396032_3396458_+|cytochrome-c	gnl|CDD|365823	pfam00034, Cytochrom_C, Cytochrome c. The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, pfam06181, has now been merged into this family.	1.96013e-15
NC_008702.1|WP_011766806.1|3389851_3391024_-|isovaleryl-CoA-dehydrogenase	gnl|CDD|173845	cd01156, IVD, Isovaleryl-CoA dehydrogenase. Isovaleryl-CoA dehydrogenase (IVD) is an is an acyl-CoA dehydrogenase, which catalyzes the third step in leucine catabolism, the conversion of isovaleryl-CoA (3-methylbutyryl-CoA) into 3-methylcrotonyl-CoA. IVD is a homotetramer and has the greatest affinity for small branched chain substrates.	0
NC_008702.1|WP_011766808.1|3392618_3393011_-|SirB2-family-protein	gnl|CDD|377264	pfam04247, SirB, Invasion gene expression up-regulator, SirB. SirB up-regulates Salmonella typhimurium invasion gene transcription. It is, however, not essential for the expression of these genes. Its function is unknown.	2.17043e-41
NC_008702.1|WP_011766815.1|3397937_3398141_+|DUF3079-domain-containing-protein	gnl|CDD|337966	pfam11278, DUF3079, Protein of unknown function (DUF3079). This family of proteins with unknown function appears to be restricted to Proteobacteria.	2.61356e-31
NC_008702.1|WP_041642730.1|3391164_3392256_+|AraC-family-transcriptional-regulator	gnl|CDD|378890	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term. AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	3.73562e-44
NC_008702.1|WP_158309411.1|3383306_3384653_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.84438e-30
NC_008702.1|WP_011766811.1|3395118_3395355_-|DUF2249-domain-containing-protein	gnl|CDD|370777	pfam10006, DUF2249, Uncharacterized conserved protein (DUF2249). Members of this family of hypothetical bacterial proteins have no known function.	9.95148e-15
NC_008702.1|WP_011766802.1|3387355_3387649_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl|CDD|368240	pfam05016, ParE_toxin, ParE toxin of type II toxin-antitoxin system, parDE. ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.	2.71903e-05
NC_008702.1|WP_011766817.1|3398832_3400161_-|ATPase	gnl|CDD|273349	TIGR00933, Trk_system_potassium_uptake_protein_trkH., potassium uptake protein, TrkH family. The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds].	4.55742e-81

Protein sequences

>NC_008702.1|WP_041642730.1|3391164_3392256_+|AraC-family-transcriptional-regulator
MKTALAPTLALPVGPGVDPTRGAAATPIAFIRAIVDAYRGYGTDPANALRLAQITPQRLADDSAHVTALQLEIMSAVAMQELDDEALGWFSRRLPWGSYGMLCRASLGAPDLGVAIKRWCRHHRLLTDDVLLHLKVTKSAATITLERRLEPPALTAGMREFCCVTLLRYLLGYACWAVDSRIPLQAAHFPYPRPEHHAVYPLLFAGPVEFDADCAGIRFDPQYLTLPLRRDERALRTMLQRALPLTVLQYRRDRLLVQRVRELLRTLTRDGGGESLTADSVAAHLHLSARTLHRQLQEEGAALQQLKDEARRERAIELLNRSNRPVKQIALAVGFRNEKSFARAFREWTGESPSGFRGRRAGE
>NC_008702.1|WP_011766806.1|3389851_3391024_-|isovaleryl-CoA-dehydrogenase
MNIPSLDFNLGETIEALRDTVKRFADEEIAPRAAAIDQNNEFPADLWKKLGDLGLHGMTVEEEYGGSAMGYLAHIIALEEVSRASASVGLSYGAHSNLCVNQIRRNGNAAQKQKYLPKLISGEHVGALAMSEPNAGSDVVSMKLRADKKGDRYVLNGSKMWITNGGDADTLVVYAKTDINAGPKGMTAFIIEKGMKGFSHGTHLDKLGMRGSNTFPLFFDDVEVPEENVLGGVGNGARVLMSGLDYERAVLCGGPLGIMAACMDVVVPYLHERKQFGQSIGEFQLMQGKLADMYSTWMATRAYVYAVGQACDRTDHARTLRKDAAGAILYSAEKATWMAGEAIQTLGGVGYTNEYSTGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA
>NC_008702.1|WP_011766805.1|3389558_3389756_+|hypothetical-protein
MNEFYVEKRANENDAHVVHKGNCPSLPEMSKLHFIGVRNNSSAPLREAAHYWYSASAPCPVCMAG
>NC_008702.1|WP_011766804.1|3388507_3388876_+|VOC-family-protein
MNNPICWFELPTVDIERAVRFYESVFAVTLRREVCGGHPMAIFPYADPQPSGALVQMPQLAPRDNGTLVYLNGGEDLNLVLERVKAAGGEVAMEKTSIGEEIGFIGLFVDCEGNRVGVYSRH
>NC_008702.1|WP_011766803.1|3387663_3388353_-|YafY-family-transcriptional-regulator
MRPADRLFQIILMLRNGRVITARALAEALEVSERTIYRDIADLIGSGAPIDGEAGVGYRLRRGYQVPPLMFTGDELEALVIGAKLVQSYADPALGKAAAQAMARIEAVLPRALEERIAGSEMRFCAPALMQPEPQREPMTLLRLGMEKGQKVQVRYRREDGEVSERTLWPLGLVFWGHCWTLGAWCELRQGFRTFRVDRIEAVELGEERFDDRYGHLWGKYLAEARGDC
>NC_008702.1|WP_011766802.1|3387355_3387649_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MTRIELAPEVADDFEWILDHLDHYRANDPAARIREIIDAIGVLASNPLIGRPTDNDNRELVIGRRSHGYLALYRYVAGIDTVFVLAVRSQREAGFER
>NC_008702.1|WP_011766801.1|3387068_3387359_+|ribbon-helix-helix-protein,-CopG-family
MSTTTIRLPDELKARVAEAAKRAGTTSHNFILEAIAEKAEQAEARAGLDAEAEQRYARIVESGQTIPWDEMRRYLEGRAAGTSAQRPSARKLAQDR
>NC_008702.1|WP_011766800.1|3385766_3386345_-|hypothetical-protein
MKKKILWLIATLVLGALGSGLWELAFRPFFALLASGALDVVTLGLDSLRNGLYEEAARGQYERVSITILSAGAGVMVGITMVLLLFPFFRQRLEGTRPSVAGSRKFTLALPLVFATTMMLLLFQRNAYINRAANHFEQLATIAAPFQSQEQRLQLHSEFAQMNTRETYVRLVETLSALAKAKGARVPEFTIY
>NC_008702.1|WP_011766799.1|3384761_3385667_-|hypothetical-protein
MCPDADTDREDRLAEAIGGALQYAANEAIVLARLEEFLSPKPAQLAADGNAVKSLNDLADRVTALYGDAPRLIIQGTNDPKPVFDTYLSAAIDEAIEVFKRARRSLCRAQAFLIGTHMLRTDPDILGIPKGGEAHQVFLRTAESVFWEHTETTYIRLAGFWDRVGQILDFAFFTIRQYERDGFSAVVDRIRANALRMQPQLEKSAAWHDIWAYKKSEREDGLQWLLSRRNLLVHSLHLRPLDESKDEELFESAFNHIDARLRSNLAPNEPEKEIEQLHLHLAQAAKLLPQVLTLCELRAKT
>NC_008702.1|WP_158309411.1|3383306_3384653_-|protein-kinase
MKLKLIKKLGDGAFADVWRALDELDREVAVKVIRPANVGVADALAHAKALARASHPNVVAVHTLETITDPDTGDSVDCVVMELLHGHTLSERLQGNKLTLPELHSIGTGIISGLRHIHNQGMTHGDLHEENVMIVGDVAKVIDILYLASLAALTTEKRETKLKRDLLSLRLLLQLLIKDSELDPAEATEFNNLIEVDADIDDIEFAFRKIVTPENVKDNARVVEHIFARVAEEGFVEGPEYAEALVEETPSSAMLPLLKRLISEKGYESKHRDYVELVWYQLANDEKVLFLQHLGASIDQETPKGRYWPNLRLLSALGKEAWNGLPLRVRIRLEGLIVKDVLAGHKDIHSAQAVSGGSLGTYARSLWRRFRKPEDLADNLISLLRQNWYTQNYVGEYFLNSVPEIARVTKRRDEFIKALRVAVANDARLIVRKIDNLPDDWVEEIQGN
>NC_008702.1|WP_011766808.1|3392618_3393011_-|SirB2-family-protein
MYMAIKHIHLLCVALSGLGFLLRGLWVLARGGLPRWLPVRVLPHVVDTLLLASAIALAVMSSQYPPHSTWITAKIVGLLVYIGLGTVALKRGRTQGVRAVAFVGALAVFGWIVSVALTRNPAGYLAGGAG
>NC_008702.1|WP_011766809.1|3393104_3393806_+|Crp/Fnr-family-transcriptional-regulator
MAGDLPQPSPALIAQLRQVPLFSELADEDIASIARHSRERSVARGEMLFQRGDTPRGFFCVLRGQIKLAFSSAAGNEKVVEVIGAGQSFGEAVMFMERPYPVFAEALMDSTLLAIGQEVLLGQLDDNPRFARKLLAGLSIRLHSLVRDVETYTLRSSMQRVIGYLLQQTPEDLDAGECRIDLPTSKQVIASRLNLTPETLSRIFHDLAEARLITVAGKRITLHDIRRLRAHEG
>NC_008702.1|WP_011766810.1|3393824_3395108_-|hypothetical-protein
MAAELSFEQAPPLSVPLRFFFTAPLFALAAGLLLVLRGDAVFASRWTPEALALTHLLTVGMMLQVMVGALFQVLPVAAGANLWRPRVLAALVHPALTLGGIALAAGFLGAGALAFHVAIGLLGTALAAVFACASAGLWRTPALGPTVWGLRAAVVALAVAAALGFALALARNGVLQPAWLALSALHQGWALGGWAGLLLAAVAWLVVPMFLLTPSYPAWFARALSIGVAVLMVAGSALWLSGWQSAEAALAIGLALAAAAFAAATLALQRRRRRKVADACLRFWQLAMASLAALAPLLAWDVAAGDPTGGALPVLVGVLALAGGFLSVMLGMLYKIVPFILWLHLRRRISRPPAMTRLVTEGRQLLHFRLHLAGVGALLVAVWLPLAAIAAGVLLALSGGLLAANLGGALKVYLAAGAGAEPARQPG
>NC_008702.1|WP_011766811.1|3395118_3395355_-|DUF2249-domain-containing-protein
MADTPVPRIIDARELAPPEPMELTLEALDTLPRGEELQLWLLREPFPLYNILKNNGFAHRVEYCDDGRFIVHIRHAGA
>NC_008702.1|WP_011766812.1|3395347_3395812_-|hemerythrin-domain-containing-protein
MDRLTRLMHQHHGHCDEVFAAAETAARVGDWAACATALQRFRADLLEHLDVEEARIFPAFEAHTGNTTGPTRVMRGEHEQMREIGGWLGEALEARDAEAFLDAVETLLILMQQHNMKEENILYPMCDRVLGADAAAFDALLDSVETALSEVSHG
>NC_008702.1|WP_011766813.1|3396032_3396458_+|cytochrome-c
MSGIMTKSMARNIFYGGSMFFFLLFLALTFHTEKELPKRDNRENLTPAVIAGKKIWETRNCIGCHTLLGEGAYFAPELGNVYVRRGPDFIKAWIKAQPTGTPGRRQMPQFNLTEQELDDLVAFLKYASEINSAKWPPNIEG
>NC_008702.1|WP_011766814.1|3396486_3397866_+|cbb3-type-cytochrome-c-oxidase-subunit-I
MQYTSQAVAKPYFVAAIGLFVGQILFGLIMGLQYVVGDFLFPALPFNVARMVHTNLLIVWLLFGFMGAAYYMVPEESETELWSPRLALVLFWVFLAAGALTILGYLFVPYARLAEMTGNDILATMGREFLEQPLITKIGIVVVALAFLFNITMTMLRGRKTAISMVLLLGLWGLAIFFLFSFVNPHNLVRDKFYWWWVVHLWVEGVWELILGALLAFVLIKVTGVDREVIEKWLYVIITLTLVTGIIGTGHHYYWIGAPEYWQWWGSIFSALEPIPFFAMTVFAFNMVNRRRREHPNRAATLWALGTGVMAFLGAGVWGFLHTLAPVNFYTHGSQITAAHGHMAFYGAYVMVVLCIISYAMPILRGRAANSNKAQVMEMWAFWLMTIAMVFITLFLTAAGILQVWLQRVSDTPLSFMATQDQISLFYWMREASGVIFLIGLLIYLASFFVKGDKKAVAA
>NC_008702.1|WP_011766815.1|3397937_3398141_+|DUF3079-domain-containing-protein
MARKFPLHPAHPERICWGCDKYCAANSLACGNGSGRTQHPAELLGDDWYLYGDWGLDVPEAEPPAAP
>NC_008702.1|WP_173364479.1|3398150_3398933_-|NAD-binding-protein
MPAASAPSRSRHRSRWGSAACLIDIPRSIQLLGRLFTEQYAFSRGDSVVVIGLGRFGSAVAQSLMRMGHDVMGIDRDAEPVQAWADLLTHAVQADSTNVSVMRQLGVADFAHAIVGIGTDLASSLMTVMALTELDIKDIWVKALTSEHGQIAQRIGAHHVVYPEADMGERVAHLVSGRMMDYIEFDDGFAIAKVRAPAPIHGRSLGEARVREKFGVTVVGVKRANEDFQHATPGTEVLADDLLIVSGPTDKVEQFASHKG
>NC_008702.1|WP_011766817.1|3398832_3400161_-|ATPase
MKTLLHPARAVALAFLVTILAGTLLLKLPLAHAEGSAAPWITAFFTAVSAVCVTGLVVVDTGSYWSWFGQGVILVLFQVGGFGMMTGATLLGLMVNRSLRLRTRLITQVETHSLGLGDISSVARLVFVVTIASELLIAALLTLRFHLAYALDWHEAAWSGLFHAVSAFNNAGFSIHADSLVRYASDAFVLLPVMTAIVVGGIGFPVLHDLRTRLRDPRHWSLHTKLTLCGTGILLAGGFVIVLAFEWDNPKTLGAMPVATRLLSAAFASVSARTAGFNSIDIGALTHESWALHYFLMFVGGGSAGTAGGVKVGTVAILLMLVVAEIRGHNDTEGFGRRVSSSAQRQAITVLVLGSGMVVLGTLFILRGTDFPTDQVIFEVISAFGTVGLSTGITADLPASGQLVLTALMYAGRVGTITLAASLALGERRMPYRYPEEHPIVG

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	337259 : 345237	8	Staphylococcus_phage(42.86%)	NA	NA
DBSCAN-SWA_2	1220420 : 1227312	9	Agrobacterium_phage(16.67%)	protease	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_008702|337259:345237|DBSCAN-SWA
CATGCTTTCGCCCCGCCTCGTGCTCGGCGTCTTTCTCGCGCTGCTGGCCGTGGCCCCGCTGGTGCTGCCGCCGTTCTACGTGACGCTGCTGAACTACATCGGTCTGTACGCCATGGTCGCGCTCGGCCTGGTGCTCTTGACCGGCGTCGGCGGCCTCACCAGCTTCGGCCAGGCCGCCTTCGTGGGGCTGGGCGCCTACACCACGGCGCTCTTGTGCACCGCCACCGAGCTGCCGGGCTGGCTCGCCTGGGCGGGTGGCTCGCCCTGGCTTGCGCTGGTCGTCGGCCTCGCCTTCACCGCGGTGGTGGCGGTGGTGCTCGGTTCGCTCACCCTCAAGCTCTCCGGCCACTACCTGCCGCTGGGCACCATCGCCTGGGGGATCAGCCTGTACTTCCTCTTCGGCACCATGGAAAGCCTGGGCGGCCACACCGGCCTCACCGGCATTCCGCCGATCTCCATCTTCGGCTGGGTGCTCGACCAGGGCGAAGAGATCTACTACCTCATCTGGGTCTTCCTGCTCGCCGCGGTCTTCACCACCCAGAACCTGCTCGATTCGCGCGAAGGCCGCGCGATCCGCGCCTTGAAGGGCGGCATGGTGATGGCCGAAGCGATGGGCGTGGATACCTCGCGCTCGCGCATGATCATCTTCGTGATCGCCGCGCTGCACGCCTGCGCCTCGGGCTGGCTCTACGCCCACATGCAGCGCTTCGTCAATCCGACCCCGTTCGGGCTGCACATCGGCATCGAGTACCTCTTCATGGCGGTGGTCGGCGGCGCCGGCCACGTCTGGGGGGCGCTGGTCGGCGCCGGCGTCATCACCGTGCTGAAGCAGTGGCTGCAGGACCTGCTGCCGCGCCTCTTCGGCCAGTCGGGCAACTTCGAAGTCATCGTCTTCGGCCTGATGATGGTGATCGTGCTGCAACGCGCCCGCGACGGCCTGTGGCCCATCCTCACCAAGCTGGTGCCGGTCAAAGCGAAGAGAAAGACGCTGGACGCCGCCGCCAAGGAACTGCCGCGCCGCGAACTCCCGGGCAAAGGCGAGCTGATCCTCGAAGCGAAGAACGTCACCCGCAAGTTCGGCGGGCTCGTGGCCAACAACAACATGAGCCTGGAAGTGAAGGCGGGCGAGATCCTCGCGCTGATCGGCCCCAACGGCGCGGGCAAGAGCACCATGTTCAACCAGATCTCGGGCGTCGACACCCCGACCTCGGGCGAGGTCCTGTTCAGGGGCAAGCCGGTGGCCGGCCACGACTCGCGCGAGATCGCACGGATGGGCATGAGCCGCAGCTTCCAGCACGTGAAGCTGCTCCCGACCATGAGCGTGCTCGAGAACGTCGCCATCGGCGGCCACCTGCGCGGCGACAAGGGCGTGCTCAGCGCCGCCTGGCGCATGGACCGCGAAGAAGAAGCGCGCCTGCTCGCGGAAGCCGCCCGCCAGATCGAACGCGTGGGCTTGGCCGAACACATGTTCGACGAAGCCGGCAGCCTCGCGCTCGGCCAGCAGCGCATCCTCGAAATCGCAAGAGCGCTCTGTTCCGACCCCTGCCTGCTGCTGCTCGATGAGCCCGCCGCGGGCCTGCGCTTCAAGGAGAAGGAAGCGCTCGGCGAGCTGCTGAAGAAACTCAAGGCCGAAGGCATGGCGATCCTCTTGGTCGAACACGACATGGACTTCGTGATGGGCCTGGTCGATCGGGTGGTGGTGATGGAGTTCGGCGAGAAGATCGCCGAGGGCCTGCCCGAAGACGTGCAGAAGGATCCGAAGGTGCTCGAAGCCTACCTGGGCGGGGTGGAGTGATGGCGAACGAAACGAAGAACAAGGTGCTGGAGATCCAGGACCTGTGCGTGGCCTACGGCAAGGTCGAAGCCTTGACCAACGCCAACCTCACCGTGGGCGAAGGCCAGATCGTCACCGTGATCGGCCCCAACGGCGCGGGCAAGACGACGATGCTCTCCGCGATCATGGGGGTGCTCAACTCCAAGGGCAAAGTCGCTTTCGACGGCAGCATCGAAGCGGTGCCGGAAGTCGAGCGGATGGTCGCGCGCGGCATGAACCTCGTGCCGGAAAAGCGCGAACTCTTCGGCGAGATGACCGTGGAGGACAACCTGACGCTGGGCGCCTTCCAGCGCTACCGCATGGGCAAGCGCGACCACGGGCAGACGATGGAAGAGGTGTATCACCTCTTTCCGCGCCTCAAAGAACGCCGCAGCCAGCTCGCCGGCACGCTCTCCGGCGGCGAGCGCCAGATGCTGGCCGTGGGCCGCGCGCTGATGGCCAAGCCCAAGCTCTTGATGCTGGACGAACCGAGCCTGGGCCTGGCGCCGCTGATCGTGCGGGAAATCTTCCGGATCATCGCGGAGCTGAGAAAGCGCGGCGTGTCGATCCTGCTGGTGGAACAGAACGCACGGGCGGCGCTGCAGGTGGCGGACTACGCGTATGTGCTCGAGACCGGGCAGATCGCGATGGAAGGGCCGGCGGCGCAGCTGAAGGATGACCCGCGGGTGATCGAGGCGTACCTGGGGCTGGGGGGCAAGCATCAGGAGATGTTGGCGACTTGAGGGCGGGTTAGAGAGGGTTTGTTCCTCCCCTTTCAAGGGGGGGGCGGAGCCGGGGCTTCGGCAAGCACTGCTTGCCGCCGGCGAAGCGGCGAGGCGAAGCCGAGACTACTGGTTAGGAGGGGGATGGGGTTGGGCTGTCGCCTGACCCCATCCCCACCCCGGCCCTCCCCTTGAAGGGGAGGGAGCAAATCGGGTCAGCCCGGTAGCTGGTGCCAGGAGGCACGGTCGTTCGTCCTGCGGCGACCGATGCTCGCCGAAACCCCGCCCTTACCCCCGACGGGAAGGCAGTAGACCGGCCCCGTCACCGTTGGACCAACGTTCGGCGATATTCGGCCCTGTTCGGCCCACCTGGGCACGTGGCCGCGCGAGGCCGTCGTCCGGCACCCAATTCGATCAAAGGAGGACGGGTCGGAATCACTCCGACGAAAGCGGTAGCAGCGACTTCTCTTTCAACTCTTTTCCACACGCGCCGTACTTGTATGCAGAATGCCACGACCGGATGTTACCGCCTGCCCCGAATCCCGCGACGGTGCTAGAATCCGGCGCGTAGAACCACATCACTTCCCTAATACCAATCGAGGAAAAGCATGAACAAAGGTGAATTCGTCGAAGCCCTGGCCGACCGTCTGGACGTATCCCGCGCTCAAGCTGACCGCGCCCTGTCCGCCGTGCTCGACATCATCTCCGAGCAACTCGGCAAGGGTGAAAAAGTGGCGTTTACCGGCTTCGGCTCTTTCGAGGTTTCCGAGCGTGCAGCGCGTACCGGTCGCAACCCGCAGACCGGCGCAACCATCGACATCGCTGCGTCCAGCGTGCCGAAGTTCACGGCCGGTGCCACGCTGAAGGCTGCAGTCAACAAGTAATACCGCCTGTTCCTCGTTTTCGGACGGCCCTCGCAACCTAAGTTGCCGGGCCGTTTGCATTTTTTCGGCCTCGCGACGGAAAAGCGGGTATAATCCGCCGCGTTGTGCAATGCAGCAGCAGGGCCATCCAGATCCAGCAGCGGGCAAATCCCGCCGCTCCGGCCCCAGGGACTGTATCCACAGCCCCATCGCCCCCGACCTCCCGCCGAACTCCATTCGTTCTCCCGATCGTCTGGCATCGTGACAACCGGTTGGTGCCGATGCGCGGTCGAGCCGGCATGTGTGTTCTCCATGTCGTAGTCGACCGGCCCACGCCCATCGCGCGCTTGTCGCCTTTGCGTCCGTCCTCGTGAACCGAGCACGGGCGGTGCGATGTCTTGCGGTCCGCTTCCGCGGATCCCAACCCGGCCCGGCCACAAGTCGGTCCGAAATTAGGAAGACAGATGACTTTCCACGCTCTCGGCCTTGCCGAAGAACTCATTGCCGCCGTTGAACAGAGCGGCTACACCACGCCGACCCCGGTGCAGGAACAGGCCATTCCGGCCGCCATCGCTGGCGGCGACCTGCTGGTGTCCTCGCACACCGGCAGCGGCAAGACGGCCGCGTTCACGCTGCCCTCGCTGCACCGCCTGGTCGGCCGCCGCCCGGCGCCGAACAGCGGCCCCCGCGTGCTGGTGCTTACGCCCACCCGCGAACTCGCCCAGCAAGTTGAAGAGGCGGTGAAGACCTACGGCCGCGCGCTGCGCTGGCTCAACACCGCCTGCCTGGTGGGCGGCGCGCCCTTCTTTGCCCAGGTCAAGCAGCTCAGCCGTCCGGTCGACGTGGTCGTCGCCACGCCGGGCCGTCTGCTCGACCACCTCAACCGCCGCAAGCTCAAGCTGTCGGACGTCGAAACCCTGGTGCTGGACGAAGCCGACCGCATGCTCGACATGGGTTTTGCCGAGGACATCGAGGCCATCGTCGGCGCGATTCCGGCCAGCCGCCAGACCCTGCTGTTCTCGGCCACGCTGGACGGCGTGGTCGGCGCGCTCGCCAACAAGCTCACCCGCAACCCGCAGCGCATCGAGATCGCCAGCACCGAAGCCAAGCGCGGCAACATCGAGCAGCGCCTGATGTTTGCGGACGACATGGGCCACAAGAGCCGCCTGCTCGAAGCCCTGCTCGGCACCGACGGCCTGCAGCAGGCGGTGGTGTTCACCGCCACCAAGAAGAGTGCCGACGAGCTGTCGCTGAGCCTGCAGGAAAAGGGTTTCTCCGCCGCTGCGCTGCATGGCGACATGCACCAGACGGTGCGTAACCGCACGCTGCAGCGCCTGCGCCAGGGCCGTATCGGCGTGCTGGTGGCCACCGACGTCGCGGCGCGCGGCATCGACGTCGCCGGCATTAGCCACGTCATCAACTTCGACCCGCCGCGCCAGGTGGAAGACTATGTCCACCGCATCGGCCGTACCGGCCGTGCCGGCCGCGACGGCATCGCGATCACGCTGTCGGGTCCGCGCGAAACCGGGCTGATCCGTGCGATCGAGCGTTTCACCGGCGACCGTCTCGCGGTCCACACCATCCCCGGTCTGGAGCCGGCGCCGCGGCGCCCGTCCGCGCCGCGTCCCGGTGGCCCGGGTCGTCGCTTCGGCAGCGGCGGCAAGCCGGGTGGCGGCTTTGGTGGCCGCAGTGAGGGTGGCTACGGCGGTCGCGGTGAAGGTGGTCGTGGCGCTTATGGCCGCGACGGCCATGCGACCCGCAATGAGCGCAGTCACGGCGACCGGCGTGACCGCGGTCCGCGCGGCTGAGCACTGCCTGGTTGAATGAAAAAAGCCCGCTGTGTAGCGGGCTTTTTTATTGGGCAGGCGCCGAATGGCAGCGCGGAACCGGCTTCAGGCCTGGCCGTCGCCCGCGTCCTTCTTGGCGCGCGCGGCTTCTACCTCGATGCTGCGCAGGCGCGCCGCGAGCTTGTCGAGCACGCCATTGACGAAGCGGTGGCCGTCGGTGCCGCCGTAGGCCTTGGCGAGTTCGATCGCCTCATTGATCACGACCCGGTAGGGCGTCTCGATGTTGTGCTTGAGTTCGTGGGTGCCGAGCAGCAGGATCGCGCGTTCGATCGGCGACAACTCCTCGATAGGGCGATGGATGAAGGGCGAGAACTCGTCCTGCAGCGCGCCGACGTTATCCAGCGTGCCGCGCAGCAGCATCACGAAGAGTTCGCGATCCACCTTGTCGAAATCGGCCGCTTCCGCTTCCACGTGGGCTTCGACCACCTGGGGCGAATTGCCCGACAGCAGCCACTGGTAAACGCCCTGCAGCGCGAGTTCGCGCGCGCGCCGGCGCGCCATCCGGCTGCTCATTGCAGGACCTTCAGCAGGTTGGCCATCTCCACCGCGGCGCGCGCGCAGTCGCTGCCTTTTTCCTGCATGCGGGCCAGCGCCTGGTCGTCGTCTTCGGTGGTCAGCACGCCGTTGGCGATCGGAATGCCGGTGTCCAGGCCGATGCGGGTGATGCCGGCGCCCATTTCGTTGGAGACGAGTTCGAAGTGGTAGGTCTCGCCGCGGATCACCGCGCCGAGCGCGATCAGCGCGTCGAACTTGCCGCTCTGCCCCATCTTCTGCAGCACCAGCGGGATTTCCAGCGCGCCGGGCACGGTGGCGATGCGGATCAGTTCGGGCGACACGCCGAGCTTCTGCAGCTCTTCGGTACAGGCGGACAGCAGCCCTTCGCAGACGTCCTGATTGAAGCGGCTCATGACGATGCCGACGCGCAGGCCTTTGCCGTTGAGGTCGGATTCGAATTCAGCGATGTTGTCGTAACGGGCCATGGTGTGAAGTGTTCTGTGGGTGGAGAGGCGCCGCGCAGGGCGCCGTTGTTGTCAGGGCTTTTCGACGAAGCCGGTGATTTCGAGGCCGAAGCCGGCCATGCTGGGGATCTTGCGCGGATTGGCGAGCAGGCGCATGCGCCCCACGCCGAGCGCCCGGAGGATCTGGGCGCCGACGCCGAACAGGCGCGGGTCCCATTTCACCGGACGTTCGACCGTGGTGCCGGTGAGGCTGGCGAGCAGGTCGGTGCCGGACTGCGGGCGGTACAACAGCACGATGGCGCCGGCTTCGGCCTTCGCGATCGCGGCCAGCGCGTCGTTCACCGGGAAGCTGTGCTTGCCGCTGGCGGGGTCGAGGAAGTCGACCACCGAGATCGGCTCGTGCACCCGCACCAGGGTTTCGCGGTCCGGGCTGATTTCGCCGCGCGTCAGCGCGAAGTGGATGTCGCCCGAGGTACGGTCTTCGAAGGCGGACAGACGGAAGCGGCCGTGCGGCGTGTCCACATCCTTTTCGGTGACCTTCTCGACCAGGTGTTCGGTGGCCGCGCGGTACTCGATCAGGTCGCGGATCGCGCCGATCTTGAGGCCGTGCTGGGCAGCGAACTCGATCAGGTCGGGCAGCCGCGCCATGGTGCCGTCGTCCTTGAGGATCTCGCAGATCACCGCGGCGGGTTCCAGTCCGGCGAGCTGGGCGAGGTCGCAGCCGGCTTCGGTGTGGCCGGCGCGGATCAGCACGCCGCCCTTCTGTGCGGTAAGCGGGAAGATGTGGCCGGGCATCACGATGTCGTCCGGCTTGGCGTGGCGGGCGACCGCCACCTGCACGGTGCGCGAGCGGTCGTGCGCCGAGATGCCGGTGGTGACGCCGGTGGCGGCTTCGATCGACGCGGTGAAGGCGGTGCCGTGCGGGGTGCGGTTGTTGCGCACCATCTGCTCCAGGCCGAGCTGGCGGCAGCGTTCGTCGGTCAGCGTCAGGCACACGAGGCCACGGCAGTGCGTGACCATGAAGTTGATCGCTTCCGGGGTGACGAATTCGGCGGCGAGGACCACATCGCCCTCGTTTTCGCGGTCTTCCTCGTCGACGAGGATGACCATCTTGCCGGCACGGATGTCGGCGATGATCTCGCTGATGGGGGAAAGTGCGCTCATGGCTTGTCCTTGGATTCTTCTTCGCGCCAGGCGAGCATGCGTTCGACGTAGCGGGCGATCAGGTCGATCTCGAGATTGACCCGGCTGCCCGCCTTGAGATGCTTGAGGTTGGTCACCGCCACGGTGTGCGGGATCAGGTTGATCGAGAAGTCCGGCCCTTCGACGCGATTGACCGTAAGGCTGACGCCGTTGACGGTGACCGAGCCCTTCTTGGCGATGTAACCGGCGATGGCGCCCGGGGCGCGGATCACCAGCTCATGGCTTTCGCCGATCGGGGCGAATTTCAGCACTTCGCCCACGCCGTCCACATGGCCGGTGACGAGGTGGCCGCCGAGGCGGTCCGACAGCTGCAGCGCCTTCTCCAGATTGACTTCGCCGCCCTCGACGTCGAGGCCGACGGTGCAGTTGAGCGTCTCGCGTGAGACGTCGAAGCGGACGCGCGGGCCGTCGCGCTCGATCACGGTGAGGCAGACGCCGCTGTTGGCGATGCTGTCGCCGATCTGCACGTCGGCGAGGTCGAGGCCGGCGGTGTCTACCGTGAGCCGCAGGCCGTCGGCCAGCGGTTCGATGCGTTCAATACGGCCGCAAGCGGCCACAATGCCGGAGAACAT

Protein sequences of DBSCAN-SWA_1

>NC_008702|337259:345237|339052_339814_+|WP_011764049.1|DBSCAN-SWA
MANETKNKVLEIQDLCVAYGKVEALTNANLTVGEGQIVTVIGPNGAGKTTMLSAIMGVLNSKGKVAFDGSIEAVPEVERMVARGMNLVPEKRELFGEMTVEDNLTLGAFQRYRMGKRDHGQTMEEVYHLFPRLKERRSQLAGTLSGGERQMLAVGRALMAKPKLLMLDEPSLGLAPLIVREIFRIIAELRKRGVSILLVEQNARAALQVADYAYVLETGQIAMEGPAAQLKDDPRVIEAYLGLGGKHQEMLAT
>NC_008702|337259:345237|343012_343483_-|WP_011764053.1|DBSCAN-SWA
MARYDNIAEFESDLNGKGLRVGIVMSRFNQDVCEGLLSACTEELQKLGVSPELIRIATVPGALEIPLVLQKMGQSGKFDALIALGAVIRGETYHFELVSNEMGAGITRIGLDTGIPIANGVLTTEDDDQALARMQEKGSDCARAAVEMANLLKVLQ
>NC_008702|337259:345237|343534_344626_-|WP_011764054.1|DBSCAN-SWA
MSALSPISEIIADIRAGKMVILVDEEDRENEGDVVLAAEFVTPEAINFMVTHCRGLVCLTLTDERCRQLGLEQMVRNNRTPHGTAFTASIEAATGVTTGISAHDRSRTVQVAVARHAKPDDIVMPGHIFPLTAQKGGVLIRAGHTEAGCDLAQLAGLEPAAVICEILKDDGTMARLPDLIEFAAQHGLKIGAIRDLIEYRAATEHLVEKVTEKDVDTPHGRFRLSAFEDRTSGDIHFALTRGEISPDRETLVRVHEPISVVDFLDPASGKHSFPVNDALAAIAKAEAGAIVLLYRPQSGTDLLASLTGTTVERPVKWDPRLFGVGAQILRALGVGRMRLLANPRKIPSMAGFGLEITGFVEKP
>NC_008702|337259:345237|337259_339053_+|WP_011764048.1|DBSCAN-SWA
MLSPRLVLGVFLALLAVAPLVLPPFYVTLLNYIGLYAMVALGLVLLTGVGGLTSFGQAAFVGLGAYTTALLCTATELPGWLAWAGGSPWLALVVGLAFTAVVAVVLGSLTLKLSGHYLPLGTIAWGISLYFLFGTMESLGGHTGLTGIPPISIFGWVLDQGEEIYYLIWVFLLAAVFTTQNLLDSREGRAIRALKGGMVMAEAMGVDTSRSRMIIFVIAALHACASGWLYAHMQRFVNPTPFGLHIGIEYLFMAVVGGAGHVWGALVGAGVITVLKQWLQDLLPRLFGQSGNFEVIVFGLMMVIVLQRARDGLWPILTKLVPVKAKRKTLDAAAKELPRRELPGKGELILEAKNVTRKFGGLVANNNMSLEVKAGEILALIGPNGAGKSTMFNQISGVDTPTSGEVLFRGKPVAGHDSREIARMGMSRSFQHVKLLPTMSVLENVAIGGHLRGDKGVLSAAWRMDREEEARLLAEAARQIERVGLAEHMFDEAGSLALGQQRILEIARALCSDPCLLLLDEPAAGLRFKEKEALGELLKKLKAEGMAILLVEHDMDFVMGLVDRVVVMEFGEKIAEGLPEDVQKDPKVLEAYLGGVE
>NC_008702|337259:345237|341120_342464_+|WP_011764051.1|DBSCAN-SWA
MTFHALGLAEELIAAVEQSGYTTPTPVQEQAIPAAIAGGDLLVSSHTGSGKTAAFTLPSLHRLVGRRPAPNSGPRVLVLTPTRELAQQVEEAVKTYGRALRWLNTACLVGGAPFFAQVKQLSRPVDVVVATPGRLLDHLNRRKLKLSDVETLVLDEADRMLDMGFAEDIEAIVGAIPASRQTLLFSATLDGVVGALANKLTRNPQRIEIASTEAKRGNIEQRLMFADDMGHKSRLLEALLGTDGLQQAVVFTATKKSADELSLSLQEKGFSAAALHGDMHQTVRNRTLQRLRQGRIGVLVATDVAARGIDVAGISHVINFDPPRQVEDYVHRIGRTGRAGRDGIAITLSGPRETGLIRAIERFTGDRLAVHTIPGLEPAPRRPSAPRPGGPGRRFGSGGKPGGGFGGRSEGGYGGRGEGGRGAYGRDGHATRNERSHGDRRDRGPRG
>NC_008702|337259:345237|344622_345237_-|WP_011764055.1|DBSCAN-SWA
MFSGIVAACGRIERIEPLADGLRLTVDTAGLDLADVQIGDSIANSGVCLTVIERDGPRVRFDVSRETLNCTVGLDVEGGEVNLEKALQLSDRLGGHLVTGHVDGVGEVLKFAPIGESHELVIRAPGAIAGYIAKKGSVTVNGVSLTVNRVEGPDFSINLIPHTVAVTNLKHLKAGSRVNLEIDLIARYVERMLAWREEESKDKP
>NC_008702|337259:345237|340401_340677_+|WP_011764050.1|DBSCAN-SWA
MNKGEFVEALADRLDVSRAQADRALSAVLDIISEQLGKGEKVAFTGFGSFEVSERAARTGRNPQTGATIDIAASSVPKFTAGATLKAAVNK
>NC_008702|337259:345237|342548_343016_-|WP_011764052.1|DBSCAN-SWA
MSSRMARRRARELALQGVYQWLLSGNSPQVVEAHVEAEAADFDKVDRELFVMLLRGTLDNVGALQDEFSPFIHRPIEELSPIERAILLLGTHELKHNIETPYRVVINEAIELAKAYGGTDGHRFVNGVLDKLAARLRSIEVEAARAKKDAGDGQA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011764048.1|337259_339053_+	branched-chain amino acid ABC transporter ATP-binding protein/permease	A0A285PWH2	Cedratvirus	4.8e-11	27.2
WP_011764049.1|339052_339814_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	4.2e-09	23.9
WP_011764050.1|340401_340677_+	HU family DNA-binding protein	A0A1P8CWT5	Bacillus_phage	3.2e-15	51.7
WP_011764051.1|341120_342464_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	1.5e-49	32.2
WP_011764052.1|342548_343016_-	transcription antitermination factor NusB	NA	NA	NA	NA
WP_011764053.1|343012_343483_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2I2L4Y7	Orpheovirus	2.4e-15	37.9
WP_011764054.1|343534_344626_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	3.9e-48	34.8
WP_011764055.1|344622_345237_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	5.3e-26	39.2

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NC_008702|1220420:1227312|DBSCAN-SWA
CTTACACCGTCGCGACTTCGGTTTCGTCGAAGGTCAGCTTCACCTTCTGCTCGTCGTCGATGTCGATCGTCACCTTGCCGCCGTTGGCCAGGCGGCCGAACAGCAACTCGTCGGCCAGCGCAGAGCGGATGGTGTCCTGGATCAGGCGCGCCATCGGGCGGGCGCCCATCAGCGGATCGAAACCACGTTCGGCCAGCCAGGCCTTGAGTTCGTCGCTGAAGTGGGCTTCGACCTTCTTCTCGTGCAACTGGGCTTCGAGCTGCATCAGGAACTTGTCGACCACGCGCAGGATGATCTCGCTGTCGAGCGCCTTGAAGGAGATGGTCGCATCCAGGCGGTTGCGGAACTCCGGCGAGAACATGCGCTTGATCTCCGACATCTCGTCCCCTGCCTCACGCTTCGCCGAGAAACCGATGACCGACTTCTGCATGGTCTCGGCGCCGGCGTTGGTGGTCATGATCATGATCACGTTGCGGAAGTCCGCCTGCCGGCCGTTGTTGTCGGTCAGCGTGCCGTGGTCCATGACCTGCAGCAGGATGTTGTAGATGTCCGGATGCGCCTTCTCGATTTCGTCCAGCAGCAGCACGCAATGCGGCTTCTTGGTGATCTGCTCGGTGAGCAGGCCGCCCTGGTCGAAGCCGACGTAGCCCGGAGGCGCGCCGATCAGGCGGCTGACCGCGTGGCGCTCCATGTACTCCGACATGTCGAAGCGCACCAGTTCGATGCCCAGCGTGTAGGCGAGCTGGCGGGCGACTTCGGTCTTGCCGACGCCGGTGGGGCCGGAGAACAGGAAGGAGCCGATCGGCTTGGCCGGGTTGCCCAGGCCGGAGCGCGACATCTTGATCGCCTTGGCGAGCGCCTCGATGGCTGCATTCTGGCCGAACACGACGTTCTTGAGGTCGCGTTCCAGCGTCTTGAGCGCGGCCTTGTCGTCGTTGGACACCGTGCGCGGCGGGATGCGGGCGATCTTGGCGACGATCTCCTCGATCTCGTTCTTGCCGATGGTCTTCTTCTGCTTGGACTTCGGCAGGATGCGCTGCGCGGCGCCAGCCTCGTCGATGACGTCGATCGCCTTGTCAGGAAGGTGACGGTCGTTGATGTACTTGGCCGACAGTTCCGCCGCGCTCGACAGCGCCGAAGCCGAGTACTTGACCCCGTGGTGCTCCTCGAAGCGGCTCTTGAGCCCCTTGAGGATCTCGACGGTCTCGGACACCGACGGCTCGGTCACGTCGACCTTCTGGAAGCGCCGCGACAGCGCGTGGTCCTTCTCGAAGATCTGGCGATACTCGTTATAGGTGGTCGCGCCGATGCACTTCAGCTGGCCGGAGGACAGCGCCGGCTTGAGCAGGTTGGAGGCATCAAGCGTGCCGCCCGATGCGGCGCCCGCGCCGATCAGCGTGTGGATCTCGTCGATGAAGAGGATGGCGTCCTGGTTTTCGACGAGCTGCTTCAGCACCGCCTTGAGGCGCTGCTCGAAGTCGCCGCGGTACTTGGTGCCGGCCAGCAGCGCGCCCATGTCCAATGCATAGACCTGGGCGTTCTCCAGGATTTCCGGCACGCGGCCTTCGACGATGCGGCGGGCGAGGCCTTCCGCGATCGCGGTCTTGCCGACGCCCGCTTCGCCGACCAGCAGCGGGTTGTTCTTGCGCCGGCGGCACAGCGTCTGGATCACGCGCTCGACTTCCTTCTCGCGGCCGATGAGCGGGTCGATCTTGCCGACCAACGCCTGCTGGTTGAGATTCTGGGTGTAGTTCTCGAGCGCACCGGCCGACTGCTTTTCCTCGGCTTCCTGTTCGCCCTGCTCACCCTGTTCGCCGGCCCCGCGGCCCTGCGTGCCGCCGCCCTGCTGCGGCGTCTTGGCGATGCCATGGGAGATGAAGTTCACCACGTCGAGGCGGGAAATGTTCTGCCGCTGGAGGAAATAGACGGCATGCGAGTCCTTCTCGCCGAAGATCGCGACAAGGACGTTGGCGCCGGTGACTTCCTTCTTGCCGCTCGACTGCACGTGCAGGATCGCGCGCTGGATGACGCGCTGGAATCCCAGGGTGGGCTGCGTGTCGATCTCTTCGCTGCCTTCCACCTTGGGGGTGTGCTCGTTGATGAAGTTGGTCAGTTCGCGGCGCAGTTCATCGAGGTTGGCAGCGCAAGCGCGCAGTACCTCGGCCGCCGACGGATTGTCGAGCAAGGCGAGTAGCAGATGCTCCACGGTGATGAACTCGTGTCGCTTTTGCCTCGCCTCGACGAAGGCCATGTGCAGGCTGACTTCAAGCTCTTGCGCGATCATTCAGTTTTCCTCCATCACGCATGCCAGTGGGTGCTGATGCTGGCGAGCAAAGGAGACGACCTGTTCCACCTTGGTCGATGCGATGTCCCGGGGAAAGACGCCGCATACCCCCATGCCCTCTCTGTGGACTTGGAGCATGACCCGCGTGGCACGTTCGCGGTCCATGCTGAAATATTTCTGCAGAACGACGATGACGAAATCCATTGGAGTGAAGTCGTCATTCAACAGAAGCACCTTGTACAACGGGGGCGGACGGGTGCGTGTCCGCTTGGCTTCCAATACGAATCCGTCTTGTTTCTGCGTGGCCATGCGGTCCATTCTAATCAAGTCGAAGCAGAGTGCAACACGCCTCCCGGAGGGGGAATTCAGCGCTCTGATGTCCCGGAAAACGACCTCGCCAATCCGATATGAGGACGTTCCGGTTGATTTCAATCTAGCCAGAAACGTGCCATTTAAAGCCCGGAAATTCGGATTGGATTTTGCGCTTCGTGCAGACGGCGGGAACGCCAGTGATGGCAAGGGGAAGGCAAAGAAAACGTTGACGCTGTGCTGACAAGTGGGTAAAAGCTAGCGCGTGCGTCGTGTAAGGTGTAATGCGCTGGTTCTGTTAGTTGCGGCCGGGCGCGCCGTTTTGGCGTCGCGGTCTGAGCCCGCAGTGCTGGTTATGCTTGACTTGACAACGAGGCATCTGCCGACGGGGATCGTCGGTTTGTATCAAGTAACTTTGAAGGATTAGAGCAATATGGCAACTGGCACTGTTAAGTGGTTCAACGACTCCAAGGGTTTTGGTTTCATTACCCCTGACGATGGCAGCGAAGACCTGTTCGCGCACTTCTCGGCCATCAACATGAACGGCTTCAAGACCCTGAAGGAAGGCGAAAAGGTTTCCTTCGAGGTCACTCAGGGGCCGAAGGGTAAGCAGGCTTCGAACATCCAGCGAGCCTGATTGCCGGACACCAGGGAGGCGCGACCCGAAGGGAATGGCCTGAAGGTCGGTCTCTAGGTAAAGCAAAAGGCCGCCGGGAATCCCGGCGGCCTTTTGCTTTACCGCGTTCACCCGTCGCAGCGGCTGCCTGCAGCGTAGCCGGGTGACGAGATGGAGAGGCGTTCTTACTGGAGCACCGCGCTCGCTGGGCGAGCGCTTCGCGACGATGGCAAGTGCTTTGTCCGACAACCGCCGGACGGTACAGGCTGCGGCTTGGGCCGCAACCGCATTACTTCAGCTTCACTTCCTTGTACGGCACGTGCTTGCGGGCAACCGGGTCGTACTTGTTGAACTCGAGCTTTTCCGGCGTGGTGCGCTTGTTCTTGGAAGTGGTGTAGAAGTGACCGGTACCGGCGGTCGATTCCAGCTTGATCTTTTCGCGGATGCCCTTGGCCATGGCGATCTCCGTTCAGTTCGGCGGCGCTAGCCGCGTGGTTCTTGCCTAAGCGCCTGGGCGCTCAGATCTTGTCGCCGCGCGCGCGCAGCTCGGCAACGACGACGTCGATGCCCTTCTTGTCGATGGTGCGCAGCGCGGCGTTGGAGACGCGCAGGCGGATCCAGCGGTTTTCGGCTTCGCTCCAGAACCGGCGGTTTTGCAGGTTCGGAAGGAAGCGGCGCTTGGTCTTGTTGTTGGCGTGGGAAACGTGATTTCCCACCATCGGTGCTTTACCGGTCACTTGGCAGACGCGAGCCATACGATGCTCCAGGGAATTCGGATTGCGAAAACGCCGGAATATACCTTATGCGGCGGGGCGTAGGCAAGGCCAATCACGGATGTTTTCTCGCGCTCCGCACGGGCCTAGATCAGCCCGCGCTCGGCGAACGAGGTCGGCTTGCCGTGCGCCGGCACGACGAAGTGATCGAGTACCCGGATATCGACGAGGGCGAGGGCGTCCTTCAGGTGGCGGGTCAGCTGCTCGTCGGCGCTGCTGGGTTCGGCGGCGCCAGAAGGGTGGTTGTGGGCGAAGATCACCGCTGCGGCATTGCGGTCGAGCGCGAGCTTGACCACTTCGCGGGGGTAAACGCTGGTTTGGGTCAGTGTGCCGCGGAACAGGTCGACCGCGTCGATCAGGGTGTTGCGGGCATCGAGCAGCAGGACGCAGAAGGTTTCGTGCGGGAGATGCCCGAGCCGCAGCCGCAGCCAGTCGCGCACCGCTTCGGGTGAGTCGAACAGGTCGCGGGCGCAGAGCGTTTCGGACAGGGCGCGCCGGGCGAGTTCCATGACCGCCTGCAGTTGGGCATACTTCGCCAGCCCCATGCCCGGGATGGCGGCGAACTCGGATGAGGTCGCGGAACAGAGGCGGGTGAGGGTGCCGAAACGGGCGATGAGGTCGCGGGCGAGGTCCACCGCGGTGCGGCCGCGGATGCCGACGCGCAAAAACAGTGCAAGGAGTTCGGCGTCTGAAAGCGCATTGGCGCCGCGCGACAGCAGTTTTTCTCGCGGGCGTTCGTCTTCGGGCCAGTCGGTGATCGCCATCTTCGCGCCAGTTTTGATTATGCCTTTGTATTTTTCCAGTTTAACGCGAATGTCATGACCAGTCTCCAAGGCAAGAGGATAGTGCTGGGTGTTACCGGTGGGGTTGCCGCCTACAAGGCGGCCGAACTGGTACGTCTGCTGGGCAAGGCCGGTGTGGACGTCCACGTCGTACTGACCGAGGCGGGCGCGCGCTTCGTCGGCGCGGTCACGTTCCAGGCGCTGTCGGGCAATCCGGTGTGGAGCGACCTGTGGGACCCGCGCATGCCCAACAACATGGCGCACATCGACCTCGGCCGTGAGGCCGACGCGGTGCTCGTCGCGCCGGCATCGGCGGACTTCATCGCCCGCATCGCGGGCGGCCGGGCCGACGATCTGCTGACCACCTTGTGCCTTGCGCGCGATTGCCCCTTGCTGGTGGCGCCTGCGATGAACCGCCAGATGTGGGAACACCCTGCCACCCAGCGCAACGTCGGCCAGGCCGTCGCCGACGGCGTCACGATGCTTGGCCCGGCGGCTGGCGACCAGGCTTGCGGGGAAACCGGCATGGGGCGCATGGAAGAGCCGGAGGCGCTGCTCGAGGGCCTGGAGGCCTTCTTCGTGGCGAAGACGCTGGCGGGGCGCCGGGTCGTGTTGACGGCCGGGCCGACCTTCGAGGCCATCGATCCGGTGCGGGGCATCACCAACAGCAGTTCCGGCAAGATGGGATACGCGCTGGCCCGCGCCTGTGCCCAGGCCGGCGCCGAGGTCGTGCTCGTCAGTGGCCCGGTGGCCTTGCCGGTGCCGAGGGGTGTTCGCCGCGTCGATGTGCGCAGTGCGCTGGAGATGCGCGGCGCCGTGCTGGACGCCCTGCCGGGCACTGACGTCTTCATCGCCGTCGCCGCGGTGGCGGACTACCGCCCGGCGCAGACGGCGGAGCACAAGATCAAGAAGTCGGGCGACACCTTGCACCTTTCCCTGACGCCCAATCCCGACATCCTCGCCGAGGTCGCGGCGCGCCCGGATGCGCCGTTCTGCGTTGGTTTTGCCGCCGAAAGCCGCGATCTGGATGCCTATGCGGAGGGCAAGCGGCGCAACAAGCGGCTGCCGCTGCTCGTGGGCAATCTGGTCGGCGACGGCCTCGGGGGCGACGACAACCTCGTCGTGCTGTACGACGATCGCGGCAAGCACCCGTTGCCACGTGCGCCCAAAACCGAACTCGCCCGACAGATCGTCGACCATCTGGCCGCCCTGCTGCCGCCTTCGAATTCCCGCTGACCCATCGGAAACCGCCATGCACCGCATCGACGTCAAGCTGCTCGATCCCCGTCTGAAAACCCATCCGCCCGCTTATGCCAGTGCCGGCGCTGCGGGGCTGGACCTGCGCGCCTGTCTCGACGCGCCGGTGCTGCTGCACCCGGGGGAGACGACCCTGGTGCCGAGCGGACTCGCCATCCACCTCGCCGACCCCGGGCTCGCCGCCATGGTGCTGCCGCGTTCCGGGCTGGGCCACAAGCACGGGATCGTGCTCGGCAATCTCGTGGGACTGATCGATTCGGATTATCAGGGGCAGGTTTTCGTGTCGGTGTGGAACCGGGGCCGCGACGTGTTCACGATCCAGCCGATGGAGCGCATCGCGCAACTGGTGGTGGTGCCCGTGCTGCAGGTCGGGTTCAACGTCGTGGACGACTTCGCCGCCAGCGAGCGGGGCGAGGGAGGGTTCGGCAGCACCGGCAAGCACTGACGTGCAGGCGAAGGGGATTCCCACCGGCGTGCACATCGTGTGCGAGCGTGGTGGACGCGTGTTGTTGATGCGCCGCGCCGGCACCGGGTTTTTCGACGGTCTCTACAGTCTGCCGGGTGGTCACGTGGAGGAGGGCGAATCGGTGCGCGCCGCGGCCGTGCGTGAGCTGCGTGAGGAAACCGGCTTGAGCGTCGACGAGGCTGCGCTGGATTGGCTCGGCGTCGTGCACCGCCGTTCCGATTCCAACCGCATCGACTTCTTCCTGCGCGCCGCAGCCTGGATGGGCGAGCCCGCGATCCGCGAGCCGGAAAAATGCGACGCGATCGGCTGGTTTGCGCCCGACGACCTACCGGCAGCGATGGTCCCCTACGTGCGCCACGCCTTGGGGCAGGCGCACACGCCCTGGATGCTGGAACTCGGCTGGTAG

Protein sequences of DBSCAN-SWA_2

>NC_008702|1220420:1227312|1223445_1223649_+|WP_011764868.1|DBSCAN-SWA
MATGTVKWFNDSKGFGFITPDDGSEDLFAHFSAINMNGFKTLKEGEKVSFEVTQGPKGKQASNIQRA
>NC_008702|1220420:1227312|1226886_1227312_+|WP_011764873.1|DBSCAN-SWA
MQAKGIPTGVHIVCERGGRVLLMRRAGTGFFDGLYSLPGGHVEEGESVRAAAVRELREETGLSVDEAALDWLGVVHRRSDSNRIDFFLRAAAWMGEPAIREPEKCDAIGWFAPDDLPAAMVPYVRHALGQAHTPWMLELGW
>NC_008702|1220420:1227312|1222703_1223012_-|WP_011764867.1|protease|DBSCAN-SWA
MATQKQDGFVLEAKRTRTRPPPLYKVLLLNDDFTPMDFVIVVLQKYFSMDRERATRVMLQVHREGMGVCGVFPRDIASTKVEQVVSFARQHQHPLACVMEEN
>NC_008702|1220420:1227312|1223917_1224085_-|WP_004258834.1|DBSCAN-SWA
MAKGIREKIKLESTAGTGHFYTTSKNKRTTPEKLEFNKYDPVARKHVPYKEVKLK
>NC_008702|1220420:1227312|1224146_1224383_-|WP_011764869.1|DBSCAN-SWA
MARVCQVTGKAPMVGNHVSHANNKTKRRFLPNLQNRRFWSEAENRWIRLRVSNAALRTIDKKGIDVVVAELRARGDKI
>NC_008702|1220420:1227312|1226435_1226885_+|WP_011764872.1|DBSCAN-SWA
MHRIDVKLLDPRLKTHPPAYASAGAAGLDLRACLDAPVLLHPGETTLVPSGLAIHLADPGLAAMVLPRSGLGHKHGIVLGNLVGLIDSDYQGQVFVSVWNRGRDVFTIQPMERIAQLVVVPVLQVGFNVVDDFAASERGEGGFGSTGKH
>NC_008702|1220420:1227312|1220420_1222703_-|WP_011764866.1|protease|DBSCAN-SWA
MIAQELEVSLHMAFVEARQKRHEFITVEHLLLALLDNPSAAEVLRACAANLDELRRELTNFINEHTPKVEGSEEIDTQPTLGFQRVIQRAILHVQSSGKKEVTGANVLVAIFGEKDSHAVYFLQRQNISRLDVVNFISHGIAKTPQQGGGTQGRGAGEQGEQGEQEAEEKQSAGALENYTQNLNQQALVGKIDPLIGREKEVERVIQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVEGRVPEILENAQVYALDMGALLAGTKYRGDFEQRLKAVLKQLVENQDAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLKCIGATTYNEYRQIFEKDHALSRRFQKVDVTEPSVSETVEILKGLKSRFEEHHGVKYSASALSSAAELSAKYINDRHLPDKAIDVIDEAGAAQRILPKSKQKKTIGKNEIEEIVAKIARIPPRTVSNDDKAALKTLERDLKNVVFGQNAAIEALAKAIKMSRSGLGNPAKPIGSFLFSGPTGVGKTEVARQLAYTLGIELVRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEQITKKPHCVLLLDEIEKAHPDIYNILLQVMDHGTLTDNNGRQADFRNVIMIMTTNAGAETMQKSVIGFSAKREAGDEMSEIKRMFSPEFRNRLDATISFKALDSEIILRVVDKFLMQLEAQLHEKKVEAHFSDELKAWLAERGFDPLMGARPMARLIQDTIRSALADELLFGRLANGGKVTIDIDDEQKVKLTFDETEVATV
>NC_008702|1220420:1227312|1224487_1225165_-|WP_011764870.1|DBSCAN-SWA
MAITDWPEDERPREKLLSRGANALSDAELLALFLRVGIRGRTAVDLARDLIARFGTLTRLCSATSSEFAAIPGMGLAKYAQLQAVMELARRALSETLCARDLFDSPEAVRDWLRLRLGHLPHETFCVLLLDARNTLIDAVDLFRGTLTQTSVYPREVVKLALDRNAAAVIFAHNHPSGAAEPSSADEQLTRHLKDALALVDIRVLDHFVVPAHGKPTSFAERGLI
>NC_008702|1220420:1227312|1225219_1226419_+|WP_011764871.1|DBSCAN-SWA
MTSLQGKRIVLGVTGGVAAYKAAELVRLLGKAGVDVHVVLTEAGARFVGAVTFQALSGNPVWSDLWDPRMPNNMAHIDLGREADAVLVAPASADFIARIAGGRADDLLTTLCLARDCPLLVAPAMNRQMWEHPATQRNVGQAVADGVTMLGPAAGDQACGETGMGRMEEPEALLEGLEAFFVAKTLAGRRVVLTAGPTFEAIDPVRGITNSSSGKMGYALARACAQAGAEVVLVSGPVALPVPRGVRRVDVRSALEMRGAVLDALPGTDVFIAVAAVADYRPAQTAEHKIKKSGDTLHLSLTPNPDILAEVAARPDAPFCVGFAAESRDLDAYAEGKRRNKRLPLLVGNLVGDGLGGDDNLVVLYDDRGKHPLPRAPKTELARQIVDHLAALLPPSNSR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011764866.1|1220420_1222703_-|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	7.1e-169	42.0
WP_011764867.1|1222703_1223012_-|protease	ATP-dependent Clp protease adapter ClpS	A0A1B1IT64	uncultured_Mediterranean_phage	9.7e-13	43.8
WP_011764868.1|1223445_1223649_+	cold-shock protein	A0A2H4N7Y6	Lake_Baikal_phage	2.0e-22	78.8
WP_004258834.1|1223917_1224085_-	50S ribosomal protein L33	NA	NA	NA	NA
WP_011764869.1|1224146_1224383_-	50S ribosomal protein L28	NA	NA	NA	NA
WP_011764870.1|1224487_1225165_-	DNA repair protein RadC	NA	NA	NA	NA
WP_011764871.1|1225219_1226419_+	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	Q9HH70	Methanothermobacter_phage	1.9e-40	33.7
WP_011764872.1|1226435_1226885_+	dUTP diphosphatase	Q2NP83	Xanthomonas_phage	2.3e-47	63.0
WP_011764873.1|1226886_1227312_+	NUDIX domain-containing protein	D0R7I2	Paenibacillus_phage	4.6e-05	33.0