CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_010943	Stenotrophomonas maltophilia K279a, complete genome	12 crisprs	csa3,DEDDh,WYL,cas3,Cas9_archaeal,DinG,PD-DExK	0	2	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_010943_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010943_1

166960-167065

Orphan

Consensus_repeat	Method
GTGGGTGCCGACCGTTGGTCGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010943_1

>merge|NC_010943|1|166960-167065|CRISPRCasFinder
GTGGGTGCCGACCGTTGGTCGGCACTTCCACTGTCCTCGTTCTGGTAGGTACCAAGCTTGCTTGGCACGGGGTCTGCTCTGGTGGGTGCCGACCGTTGGTGGCACA

>NC_010943|1|1|166960-167065|CRISPRCasFinder
GTGGGTGCCGACCGTTGGTCGGCAC	TTCCACTGTCCTCGTTCTGGTAGGTACCAAGCTTGCTTGGCACGGGGTCTGCTCTG
GTGGGTGCCGACCGTTGGTGGCACA

Protein	Signature genes	Signature genes Name	Protein_function
NC_010943.1\|WP_012478737.1\|176970_177858_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012478723.1\|160139_160751_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|176643
NC_010943.1\|WP_012478722.1\|158059_160129_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_010943.1\|WP_044571117.1\|160835_161321_-\|META-domain-containing-protein	unknown	unknown	gnl\|CDD\|377111
NC_010943.1\|WP_012478734.1\|174476_175046_+\|superoxide-dismutase-family-protein	unknown	unknown	gnl\|CDD\|376292
NC_010943.1\|WP_012478733.1\|172934_174383_+\|nitrogen-regulation-protein-NR(I)	unknown	unknown	gnl\|CDD\|273818
NC_010943.1\|WP_024956257.1\|157013_158003_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|223506
NC_010943.1\|WP_044569332.1\|156169_156961_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NC_010943.1\|WP_012478728.1\|167153_167900_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|225567
NC_010943.1\|WP_012478729.1\|167967_169134_+\|MltA-domain-containing-protein	unknown	unknown	gnl\|CDD\|225377
NC_010943.1\|WP_012478732.1\|171880_172942_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226370
NC_010943.1\|WP_005407550.1\|163382_164792_+\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|181884
NC_010943.1\|WP_012478730.1\|169242_169557_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_004134334.1\|165139_165478_+\|P-II-family-nitrogen-regulator	unknown	unknown	gnl\|CDD\|223424
NC_010943.1\|WP_012478731.1\|169664_171710_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_010943.1\|WP_012478735.1\|175077_175704_+\|superoxide-dismutase-family-protein	unknown	unknown	gnl\|CDD\|376292
NC_010943.1\|WP_043034922.1\|165499_166930_+\|ammonium-transporter	unknown	unknown	gnl\|CDD\|182630
NC_010943.1\|WP_012478725.1\|161463_162291_-\|META-and-DUF4377-domain-containing-protein	unknown	unknown	gnl\|CDD\|379548
NC_010943.1\|WP_012478726.1\|162364_163159_-\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|234712
NC_010943.1\|WP_099470504.1\|175804_176872_-\|TonB-family-protein	unknown	unknown	gnl\|CDD\|367555

Protein	Function_ID	Function_description	E-value
NC_010943.1\|WP_012478723.1\|160139_160751_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|176643	cd00865, PEBP_bact_arch, PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea. PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.	2.03917e-51
NC_010943.1\|WP_012478722.1\|158059_160129_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	4.40419e-24
NC_010943.1\|WP_044571117.1\|160835_161321_-\|META-domain-containing-protein	gnl\|CDD\|377111	pfam03724, META, META domain. Small domain family found in proteins of of unknown function. Some are secreted and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene. Over-expression in L.amazonensis increases virulence. A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond.	0.00275364
NC_010943.1\|WP_012478734.1\|174476_175046_+\|superoxide-dismutase-family-protein	gnl\|CDD\|376292	pfam00080, Sod_Cu, Copper/zinc superoxide dismutase (SODC). superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold.	1.54818e-41
NC_010943.1\|WP_012478733.1\|172934_174383_+\|nitrogen-regulation-protein-NR(I)	gnl\|CDD\|273818	TIGR01818, Nitrogen_assimilation_regulatory_protein, nitrogen regulation protein NR(I). This model represents NtrC, a DNA-binding response regulator that is phosphorylated by NtrB and interacts with sigma-54. NtrC usually controls the expression of glutamine synthase, GlnA, and may be called GlnL, GlnG, etc. [Central intermediary metabolism, Nitrogen metabolism, Regulatory functions, DNA interactions, Signal transduction, Two-component systems].	0
NC_010943.1\|WP_024956257.1\|157013_158003_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|223506	COG0429, COG0429, Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only].	8.97995e-28
NC_010943.1\|WP_044569332.1\|156169_156961_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	4.77183e-38
NC_010943.1\|WP_012478728.1\|167153_167900_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|225567	COG3023, ampD, N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane].	9.36923e-53
NC_010943.1\|WP_012478729.1\|167967_169134_+\|MltA-domain-containing-protein	gnl\|CDD\|225377	COG2821, MltA, Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane].	6.26844e-116
NC_010943.1\|WP_012478732.1\|171880_172942_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|226370	COG3852, NtrB, Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms].	2.26232e-109
NC_010943.1\|WP_005407550.1\|163382_164792_+\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|181884	PRK09469, glnA, glutamate--ammonia ligase.	0
NC_010943.1\|WP_099470504.1\|175804_176872_-\|TonB-family-protein	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	4.72285e-08
NC_010943.1\|WP_004134334.1\|165139_165478_+\|P-II-family-nitrogen-regulator	gnl\|CDD\|223424	COG0347, GlnK, Nitrogen regulatory protein PII [Amino acid transport and metabolism].	3.60313e-56
NC_010943.1\|WP_012478731.1\|169664_171710_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	6.31002e-55
NC_010943.1\|WP_012478735.1\|175077_175704_+\|superoxide-dismutase-family-protein	gnl\|CDD\|376292	pfam00080, Sod_Cu, Copper/zinc superoxide dismutase (SODC). superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold.	4.25941e-52
NC_010943.1\|WP_043034922.1\|165499_166930_+\|ammonium-transporter	gnl\|CDD\|182630	PRK10666, PRK10666, ammonium transporter AmtB.	2.06677e-175
NC_010943.1\|WP_012478725.1\|161463_162291_-\|META-and-DUF4377-domain-containing-protein	gnl\|CDD\|379548	pfam14302, DUF4377, Domain of unknown function (DUF4377). This domain family is found in bacteria and archaea, and is approximately 80 amino acids in length.	1.42729e-26
NC_010943.1\|WP_012478726.1\|162364_163159_-\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|234712	PRK00281, PRK00281, undecaprenyl-diphosphate phosphatase.	7.3206e-85

>NC_010943.1|WP_043034922.1|165499_166930_+|ammonium-transporter
MKMRLLTGWQARFHVVWLLMLLSALAAGAWPGNAHAQAQVSPLPSESVAVEPLQDTAAAAAAPAVAEAAAAYDHGDVAWMLTSTLLVLLMVVPGLALFYGGLVRSKNVLSVLSQILVVFSLVLLLWVAYGYSAVFSAGNPFFGSFTEFAFLKGFTPESVGNTPIKGLPDYLFVAFQSTFAGITTALIVGAFAERIKFRAVLLFSALWFTLSYIPMAHIVWGGGYLGELGAIDFAGGTVVHINAGVAGLVAAWFVGKRLGYGQTALKPHNVPFTYIGAMLLWVGWFGFNAGSAAAADTVASLAFLNTVLATAAAVLGWTLVEAISKGKPSALGAASGAVAGLVGITPACGTVGPLGAIIIGFVAGVVCVWGVTGLKRLLKVDDTADVFGVHGVGGIVGAILTGVFSAQSLGGTKAGLDIAHQVWVQVVSVGLTVVWSAVVTAVILLVVKVVVGLRVTEEAERTGLDVTSHGESAYEA
>NC_010943.1|WP_004134334.1|165139_165478_+|P-II-family-nitrogen-regulator
MKLISAIIRPFKLDEVREALSDAGVSGITVTEVKGFGRQKGHTELYRGAEYVVDFLPKIKIETVVTDERADAVIEAIQSSAGTGKIGDGKIFVTAVEQVIRIRTGEIGADAL
>NC_010943.1|WP_005407550.1|163382_164792_+|type-I-glutamate--ammonia-ligase
MSVENVEKLIKDNQIEFVDLRFVDMRGVEQHVTFPVSIVEPSLFEEGKMFDGSSIAGWKGINESDMVLLPDTASAYVDPFYADPTIVISCDILDPATMQPYGRCPRGIAKRAEAYLKSSGIAETAFFGPEPEFFIFDSVRFANEMGNTFFKVDSEEAAWNSGAKYDGANSGYRPGVKGGYFPVPPTDTLHDLRAEMCKTLEQVGIEVEVQHHEVATAGQCEIGTKFSTLVQKADELLRMKYVIKNVAHRNGKTVTFMPKPIVGDNGSGMHVHQSLSKGGTNLFSGDGYGGLSQLALWYIGGIFKHAKAINAFANSGTNSYKRLVPGFEAPVMLAYSARNRSASCRIPWVSNPKARRIEMRFPDPIQSGYLTFTALMMAGLDGIKNQIDPGAPSDKDLYDLPPEEEKLIPQVCSSLDQALEALDKDREFLKAGGVMSDDFIDGYIALKMQEVTKFRAATHPLEYQLYYAS
>NC_010943.1|WP_012478726.1|162364_163159_-|undecaprenyl-diphosphate-phosphatase
MSDLLSALLLGILEGLTEFLPISSTGHLLIAQHWLGARSDFFNIVIQAGAIVAVVLVFRQRLLQLATGFNQRGNREYVFKLGAAFLVTAVVGLVVRKAGWSLPETVSPVAWALIIGGVWMLLVEAYTARLPDRDQVTWTVAIGVGLAQVVAGVFPGTSRSASAIFLAMLLGLSRRAAAAEFVFLVGIPTMFAASAYTFLEMAKAGQLGSEDWADVGVAFLAAAITGFVVVKWLMGYIKSHRFTAFAIYRIALGAALLLWLPSGS
>NC_010943.1|WP_012478725.1|161463_162291_-|META-and-DUF4377-domain-containing-protein
MNRKLTLLLPLALMAACSQTPAPAGTGGDDVAPAAAKAADQQTLAHLDAQRLQSQHWLLQQATGADGKRIDALFAREDKPVTLDFADGRLSVSNTCNRMGGGYTLADGKLTVSAMASTMMACTDKALMALDEAVSSRLQGELKAEQDADGKLTLTTAKGDVLVFNPEPTAETRYGGAGETVFLEVAAKTEKCSHPLIPDYQCLQVREVKFDDKGLKQGEPGKFENFYGNIEGYTHEDGVRNVVRVKRYEVKNPPADAPSQAYVLDMVVESAIEKK
>NC_010943.1|WP_044571117.1|160835_161321_-|META-domain-containing-protein
MKHVPVLIIAALLAMSANVAAASTPSTPSTPSTDQLEAHLWQLVRATNAQGKRIDALFVRGRAPYTLRFQSGFMSELNLCNHVSNEYRLQGNLLILRNSVQTTALCVDQRLPTQQKLAGKLMHGEGSAPTLALDDRGALVLRNARGDTAVFEPAALQADGR
>NC_010943.1|WP_012478723.1|160139_160751_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MQLTSHSLTNGAPIDREFAAGDANGFAPDRNPHLAWSGAPAGTRSFLLVCVDPDVPTVPETVGRGDMSVPRDQPRCDFVHWVMADIPATVQEIAAGSCSDGFVVKGKPAPAGPAGSRQGLNDFTGWFAGNPDMAGDYLGYDGPYPPFNDERMHRYFFRVFALDVASLDLPQRFTAADAYRAMHGHVLAEAALHGTYTLNPALG
>NC_010943.1|WP_012478722.1|158059_160129_+|tetratricopeptide-repeat-protein
MQDQIIQALRQNQADQAVQLAQAWTRDEPGQANAHRWLALALQQQGNAEEAMEALQQALRLAPDDAQLHLQHAGLLLALRQFEGADEALVRTTGLDPNSFSAYLMQAHLAIGRNDFDEAQRISTLAARVEPDHPELLTIDGMVALRRGDADRALALLSAASKALPDDTRVLYALGFAYLGKDMLAFAEQSFRRVLELNPSLSSLHGLVVQLALRQGNVPAAAEAMQVALQQPEMDVPSMRRLAGELSLRNGQPLQALDYLLPLLETQPEDRQVLQLLLMSWQRLGREDEARARLDAVLDTDDQLHDVWLARLAIEQVGSESAVTAVERWMAAMPAHLPALEARLRLHDMAGEHAQAEAIAERIVSLEPGRVSGETRLVEGLLQRDPAAAVARVQALIELAPEEHRADLRTWMGEIQDRAGQPQDALRTWLSLQADQAPQRLPLPPQAKSPPSWPDKGSIDGDASSAPIFLWGPPGSGVERVATGLAAASPVLRSDRYTNTPPDDAFQNYNTLQDLASGVLTPERLVQRWREQLPARGLQSDTVIDWLLWWDNALLWALRPQLPQGRLVLVLRDPRDMLLDWVAYGAAAPLAMTSLAEASEWLTRALTQIATLHEDDLYPHVLLRIDQIGNDPQAMAELLGRLFERPMPPAAQLGAPRLPAGHWRNYRDVMSAAFAQLTPVAVRLGYPEE
>NC_010943.1|WP_024956257.1|157013_158003_+|alpha/beta-fold-hydrolase
MHAADYQPPRWLRNPHLQSMLSSSRMRLQRGLLLLAATGAVSEELILDGGDGVRLQGWHSHVEGREPKGIALLLHGWEGSAESSYMRMAAARMIEQGFDVVRLNFRDHGNTHHLNPGIFHSNLIDEVVHAAGDIAQRWPQLPLVAAGYSLGGNFVLRLALRAPAAGVPLLRVASVCPVLDPALTMESIENGPAMYDWYFRRKWAGSLRRKRDLFPELSDCDDRVLKLDIRALTAWLVERHTSFGSLQAYFDGYSIAGDRLSSLQVPADILMAQDDPVIPYATFSNWQLPGQARLETACWGGHCGFIENWRGDGFSERWVAQRLQRVLQA
>NC_010943.1|WP_044569332.1|156169_156961_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MTSPTPAPRGGVARVCRYLYRVPLLLVHIIVFLPLILIGMLPPWGELRVGEATFGAKVVNWWQGGLMWIFGFRLVQVGAPLPGAVLFVANHVSWVDICILHSQRMMGFVAKREIASWPLVGWLAARGQTIFHQRGSTESLGGVMQVMADRLREGKAVGVFPEGRTRGGHEVGPFHARIFQAAVETGVPVQPVALVYGAKGDAQTIVAFGPNESFFANFLRLLGEPARRAEVHFLAPIGAQDLEGRRRIAETSRARIVAAMSAG
>NC_010943.1|WP_012478728.1|167153_167900_+|N-acetylmuramoyl-L-alanine-amidase
MHPIRTVLMLSACLLLAACASAPQETRNPLATWVPSPNQNARTPVIIVIHHTEQKSVQQSLHTLRTANSGGPVSAHYLVGADGHRYQLVADERRAWHAGAGRWGTITDLNSASIGIELDNDGRSPFSAAQIESLIVLLRDLTSRLNIPPRQVIGHADLAPTRKQDPSRFFPWQQLAEVGFGVWPRAADGAAPEGFDAWNALARFGYPLDNREATVAAFHRRFRGRDDLPKTLDAEDARILYSLLLQTP
>NC_010943.1|WP_012478729.1|167967_169134_+|MltA-domain-containing-protein
MIDSATFVKRRHCILLAAAVLAGCATTAPRTGSEAPTPTMPPAATYAKAAWSALPPVSNSDLQAGFVAWRSSCTRLKNDAVWAKPCATAAAVSDKDPAAIRQFLQRDLDAYALRAGGHQADGLITGYYEPIYAGSLTRTDKATVPVYGTPDDLVVVQLESLYPELKGKRLRGRVEGKVLKPYDDAGTIAAQGANAPVLAWLTDPMDLQLLQIQGSGRVRLADGKQVRLAYAEQNGHPYRAVGRWLVDQGQLKKEDVTMDAIRAWARANPARVPELLRSNPSYVFFVRNPDSPEGPRGSLNVPLTAGYSVAVDRSVVPLGSLLWLSTTRPDGTPVVRPVAAQDTGGAIAGEVRADLYWGSGDAAGKLAGDMKQKGNIWMLWPKGAPLPN
>NC_010943.1|WP_012478730.1|169242_169557_+|hypothetical-protein
MTYAKHNAKRGAKSAAKKYYKHWAESGLGKGNVLMEARGEKIVRQVEIYGTKMVWADEHAHSDDRFLLADQPVSFLDFDEDDEISAREFEAAWKKAREATGYPV
>NC_010943.1|WP_012478731.1|169664_171710_+|TonB-dependent-receptor
MKTPTLVAALAAAPFAPEAFAQSADAALTLGKVQVHQHGEGQLSARQVLTSVDVLGADQIEDRNVSHSWELLGQMPGIQLTETRQGAESGKVSFRAFNGEGYLNAIKTLIDGIPSNVNSGNQRFIDMLFPLDISYIEVVRGTNDPRYGLHNIGGNVNFGTRQGGSYTDARLAYGSYNTRDAQLAVGREANGFAQNYFVGTQASDGYRDHDTSKKYSLGGKWFFGTLDEGLRVGLTARAYHHEADEPGFMTAEELRTLRRGSELRNGNDGDDRDMRQIAAHVDLKLSDALTFGTRLYYNRYEDDRRVTFSDLPTGNLPRQRRVWDERQTGLLSTLTWQASPALTVEGGLNYEQQDNGYIRERYAYAEPTDYSQPPARVQNDDRHSFDNWGAYVQAVYQPVEAWKIVPAYRVDRFSGRTHLMNGITARLQDYGSIGQPKLSIIHSLGQTTHVYANWGRTFQVLTGSTAPAYLTPGQAPMQPSTNTGMELGLKFQPFQGAQARLAVWQQDAENEVSNMPATGTTVTLGKTRRRGVDAQLSLQLGDDWTVWASHAYQEAKITRDDRDAGISLQGREVAATPRHISNLGVDYRATDALRLGLQARAQGDYYLEERNVAGKFGGFAVLDLSAAYQLTPRFSVDLQLKNVTGRQYAYAWYDSFFWDSARPMFSPAPGRSVFVGLNMKL
>NC_010943.1|WP_012478732.1|171880_172942_+|two-component-sensor-histidine-kinase
MSDPAPPPSLDALGTPLAWAGADGCIAGCNPAFARWLGVSVRRLLGRPLVALEVQGEALAHFLARDERDSLRLNRLALAVPGEAPRFAEGWMSRRDDGGWLLEAHPVDEFPGLDPTQALPSALSAALKGLAHELRNPLAGLKGAAQLLARRAAQRDAGERELIELIGSEIERLNGLLDQLLSPAPAAPHAELNIHAALERVLRLAESEAGWAVRLQRDYDPSIPEFHGDADRLTQAVWNLVRNAIQAGAGNITLRTRVEHGVRIAEQLHTLALRLEIADDGRGVPEELAEHLFLPLVSGRAEGTGLGLALAQQVAREHRGTLTYRSRPGHTVFTLLLPIVSGAAPAEEAPRDV
>NC_010943.1|WP_012478733.1|172934_174383_+|nitrogen-regulation-protein-NR(I)
MSESSSSPQRIWVVDDDRAVRFVLCTALREAGYQVVDFDSAAPALQALSEGPPPALLFTDVRMPGDDGLVLLDKLKAALPQLPVVVMSAYTDVASTAGAFRGGAHEFLSKPFDLDDAVALAQRVLPAVAPALAAATPAAEAHSDQPPQLVGDTPPMRALFRAIGRLAQAPLAVLITGETGTGKELVANALHRESPRAQGPFVALNTAAIPSELLESELFGHEAGAFTGAQRRHIGRFEQADGGTLFLDEIGDMPLPLQTRLLRVLAQGEFFRVGGRELIRVDVRVVAATHQDLEGLVAQGKFRADLLHRLDVVRLQLPPLRERREDIAQLASTFLAAAARKLDTPPKRLTAAALQALREHDWPGNVRELENVCWRMAALAAADTIGVADVDTALNRTRGRRSSTTSADPGQWEALLAEWARRQLAEGVEGLHAQVRERVDHALLEAALQITHGRRAEAAARLGLGRNTLTRKLGAGRRRGGH
>NC_010943.1|WP_012478734.1|174476_175046_+|superoxide-dismutase-family-protein
MRLSFAILPLSAAVLLSACGSAPKKTEPTPPPPTVVSAAKQGEANIAPASASIVSGRIALMVEPGGIHITGLIGGLQPMQQAGFHIHERGDCSAVDASSAGNHFNPGGAAHGRAGTGKHHLGDMDNLRADAQGRANVDIHLKGVTLGGGAATDIAGRALVVHANADDYRSQPAGNAGVRIACGVIRVVR
>NC_010943.1|WP_012478735.1|175077_175704_+|superoxide-dismutase-family-protein
MRLIHTSLFAAIAALGLAACNQQPAAPQAETPPAAPADGATTEPAATPAPAAAPAADATASAELAPTQGNETKGSVTFKVVDGKVHVTGQISGLKPGSEHGFHIHEKGDCSAPDGMSAGGHFNPGKQDHGNVATDPHHGGDMPNIKADDKGVATIDGPVSSNVNIGKGDDFDIIGRGLIVHADADDYKTQPTGNAGARLACAVIQKAQ
>NC_010943.1|WP_099470504.1|175804_176872_-|TonB-family-protein
MLCRLQCAGLTLLAAAVCGLPIMAQAAVPVAATPTCTVAPAFAAAVAEPEVYDSHISFSNTVKVQVNVDAQGRAHDARVLNGSRNRVLDDAARQAALSWKYQCTGPGGIAQPVVPVPEPACRLDRLSWADNEPRFSSAVRSSGLRGSAEVWLRPVAGDPAKTEVKIGRSSGDARIDDTLLNAARNWRLTCPPDAPVKHPWISFTQSFNFEPRRQPAATEASEPEPDDVVIANDALLEFGTVAGFVEALPKMKGVDLAPDQSSQPGMTLYNTSLGAIMREIEMTEGRLKPVTMTHWLVMVPPHRTAPAVVRTFKREVIDAKTGKAHMQTDISILCESGPAECAELRRRRDTLLRSP
>NC_010943.1|WP_012478737.1|176970_177858_-|hypothetical-protein
MSKPDPAMNALGVLALELAGGEVPRQAVLSAEQAGELADRVGRDLSKLVPQVAELDLVFAAAHFDPAEVLRPGWPIHRRLEELQMRAPGRNQGPRLLAFGTDAQGDVPLPFQADASLVGGGLRVVPFLLTGSDVATTNAVAEALEDTLLANGMAHADTALMAQNTFGARIEHARYFTVNDLAAMMSMQYDNQGLAALWPLIETAIMAPGEDEWLNAAPEPLLRYTHGEARMALFDPAGWCAHYDHGKNDCDRLKGIYEQFLMRQRQMAAVLEAHGVPVLFVHCEAGQDARELLAR

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Crispr_ID: NC_010943_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010943_2

332111-332189

Orphan

Consensus_repeat	Method
CAGGAGCGCAAGACAGATTCAGCGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010943_2

>merge|NC_010943|2|332111-332189|CRISPRCasFinder
CAGGAGCGCAAGACAGATTCAGCGCGGCCGAGGCCCGGCGGGGGCGGCAGGCGCAGGAGCGCAAGACAGATTCAGCGCG

>NC_010943|2|2|332111-332189|CRISPRCasFinder
CAGGAGCGCAAGACAGATTCAGCGCG	GCCGAGGCCCGGCGGGGGCGGCAGGCG
CAGGAGCGCAAGACAGATTCAGCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_010943.1\|WP_012478857.1\|325027_325735_-\|terminase	unknown	unknown	gnl\|CDD\|222861
NC_010943.1\|WP_044569400.1\|327806_329564_+\|terminase-ATPase-subunit-family-protein	unknown	unknown	gnl\|CDD\|222859
NC_010943.1\|WP_012478861.1\|329563_330574_+\|phage-portal-protein	unknown	unknown	gnl\|CDD\|222860
NC_010943.1\|WP_012478855.1\|324240_324456_-\|tail-protein-X	unknown	unknown	gnl\|CDD\|283209
NC_010943.1\|WP_012478874.1\|339662_340433_+\|DUF3011-domain-containing-protein	unknown	unknown	gnl\|CDD\|371422
NC_010943.1\|WP_049886003.1\|332896_333241_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012478862.1\|330745_331456_+\|site-specific-DNA-methyltransferase	unknown	unknown	gnl\|CDD\|223931
NC_010943.1\|WP_044569408.1\|338661_339069_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012478872.1\|338258_338582_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012478856.1\|324455_324923_-\|head-completion/stabilization-protein	unknown	unknown	gnl\|CDD\|368674
NC_010943.1\|WP_148272144.1\|326788_327703_-\|GPO-family-capsid-scaffolding-protein	unknown	unknown	gnl\|CDD\|368675
NC_010943.1\|WP_012478858.1\|325738_326755_-\|phage-major-capsid-protein,-P2-family	unknown	unknown	gnl\|CDD\|368296
NC_010943.1\|WP_012478871.1\|337898_338201_+\|putative-addiction-module-antidote-protein	unknown	unknown	gnl\|CDD\|188241
NC_010943.1\|WP_044569402.1\|331522_332011_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012478870.1\|337552_337840_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|162974
NC_010943.1\|WP_080047722.1\|330576_330828_+\|Com-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|287133
NC_010943.1\|WP_012478865.1\|333315_334077_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350289
NC_010943.1\|WP_012478867.1\|334914_335202_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012478868.1\|335567_336692_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012478869.1\|336719_337319_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_010943.1\|WP_012478857.1\|325027_325735_-\|terminase	gnl\|CDD\|222861	PHA02537, M, terminase endonuclease subunit; Provisional.	3.76659e-71
NC_010943.1\|WP_044569400.1\|327806_329564_+\|terminase-ATPase-subunit-family-protein	gnl\|CDD\|222859	PHA02535, P, terminase ATPase subunit; Provisional.	0
NC_010943.1\|WP_012478861.1\|329563_330574_+\|phage-portal-protein	gnl\|CDD\|222860	PHA02536, Q, portal vertex protein; Provisional.	6.92421e-169
NC_010943.1\|WP_012478855.1\|324240_324456_-\|tail-protein-X	gnl\|CDD\|283209	pfam05489, Phage_tail_X, Phage Tail Protein X. This domain is found in a family of phage tail proteins. Visual analysis suggests that it is related to pfam01476 (personal obs: C Yeats). The functional annotation of family members further confirms this hypothesis.	1.13855e-18
NC_010943.1\|WP_012478874.1\|339662_340433_+\|DUF3011-domain-containing-protein	gnl\|CDD\|371422	pfam11218, DUF3011, Protein of unknown function (DUF3011). This bacterial family of proteins has no known function. Most members belong to Proteobacteria.	2.47423e-15
NC_010943.1\|WP_012478862.1\|330745_331456_+\|site-specific-DNA-methyltransferase	gnl\|CDD\|223931	COG0863, COG0863, DNA modification methylase [DNA replication, recombination, and repair].	2.35009e-33
NC_010943.1\|WP_012478856.1\|324455_324923_-\|head-completion/stabilization-protein	gnl\|CDD\|368674	pfam05926, Phage_GPL, Phage head completion protein (GPL). This family consists of several phage head completion protein (GPL) as well as related bacterial sequences. Members of this family allow the completion of filled heads by rendering newly packaged DNA in the heads resistant to DNase. The protein is thought to bind to DNA filled capsids.	6.48649e-54
NC_010943.1\|WP_148272144.1\|326788_327703_-\|GPO-family-capsid-scaffolding-protein	gnl\|CDD\|368675	pfam05929, Phage_GPO, Phage capsid scaffolding protein (GPO) serine peptidase. This family consists of several bacteriophage capsid scaffolding proteins (GPO) and some related bacterial sequences. GPO is thought to function in both the assembly of proheads and the cleavage of GPN. The family is found to function as a serine peptidase, with a conserved Asp, His and Ser catalytic triad, as in subtilisin, and as represented in MEROPS:S73. The family includes capsid assembly scaffolding protein from Enterobacteria phage P2 which cleaves itself and then becomes the scaffold protein upon which the bacteriophage prohead is built - a mechanism quite common amongst phages.	7.54832e-115
NC_010943.1\|WP_012478858.1\|325738_326755_-\|phage-major-capsid-protein,-P2-family	gnl\|CDD\|368296	pfam05125, Phage_cap_P2, Phage major capsid protein, P2 family.	0
NC_010943.1\|WP_012478871.1\|337898_338201_+\|putative-addiction-module-antidote-protein	gnl\|CDD\|188241	TIGR02684, conserved_hypothetical_protein, probable addiction module antidote protein. Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the downstream member of a gene pair. It is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, are located often with prophage regions, but also both in integrated plasmid regions and in housekeeping gene regions. Analysis suggests that the gene pair may serve as an addiction module. [Mobile and extrachromosomal element functions, Other].	1.0606e-34
NC_010943.1\|WP_080047722.1\|330576_330828_+\|Com-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|287133	pfam10122, Mu-like_Com, Mu-like prophage protein Com. Members of this family of proteins comprise the translational regulator of mom.	1.48708e-10
NC_010943.1\|WP_012478865.1\|333315_334077_-\|NYN-domain-containing-protein	gnl\|CDD\|350289	cd18722, PIN_NicB-like, LabA-like PIN domain of Pseudomonas putida S16 NicB and related proteins. Curiously NicB from Pseudomonas putida S16 is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine. This subfamily also includes the uncharacterized CPP15 (plasmid) protein from Campylobacter jejuni. This subfamily belongs to LabA-like PIN domain family which includes Synechococcus elongatus PCC 7942 LabA, human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.05535e-30
NC_010943.1\|WP_012478870.1\|337552_337840_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|162974	TIGR02683, Uncharacterized_protein_HI_1419, putative addiction module killer protein. Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the upstream member of a gene pair, where the downstream member is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, often are located with prophage regions, but also in both integrated plasmid regions and near housekeeping genes. Analysis suggests that the gene pair may serve as an addiction module.	8.11863e-43

>NC_010943.1|WP_044569402.1|331522_332011_-|hypothetical-protein
MNYPLDAFKTVVPSQAPSGTLFRCQGVWAIKADPVQIQGQEVGQMLMLDGRYPGAVAVAPDREALALADGYDWMVFTDLIAVAVHAQHLPAVRITPNGPLIYGHAWGRRDVLMAVTQGGQHLEEAGYDFFIQNFSIWLVDDAKRQVGSHPLVRVSTPAPALL
>NC_010943.1|WP_012478862.1|330745_331456_+|site-specific-DNA-methyltransferase
MNNELIQGDALTILPTLPANSFDALITDPPYASGGTHASARQRGPNEKYMQSGGPRLHADFPSDERDQRSHLAWMHLWLAQCNRVLRDGAPVLLFTDWRQLPLTTDALQCAGFTWRGVAVWDKTGGVRPQRGRFSNQAEYVVWGSKGGMPLGRAAPTLPGVFREAVRKADKHHLTGKPTDLMRQLVRICEQGGRILDPFAGSGTTLVAAEAEGYSWTGIEMTGHYFDVAKSRLPSP
>NC_010943.1|WP_080047722.1|330576_330828_+|Com-family-DNA-binding-transcriptional-regulator
MTRQNLRCGACARLLAKAVGDHDLQIKCPRCGEMNHMKAQSLPMDRRERHHEESSTHEQRTDPRRCADHPADPPGQQLRRPHH
>NC_010943.1|WP_012478861.1|329563_330574_+|phage-portal-protein
MADTDQGASVAPPATTEVFTFGDPTPVLESRGIFDYLECWRNGRYYEPPVDLHGLSRTTRANPYLQSGLTFKRNMLVRTFRPHKLLTREAFAQLALDYITFGMAYVERRRAMSGNAHSLAVPLAQYMRRGVEAGEFFQVRAGRIEHEFKPGEVFQLREADPDQEVYGLPEWMPAVQSALLNESATLFRRKYYNNGSHAGFILYLTDPQPEDGDVSKLREALRQSRGPGNFRNLFVHSPNGKKDGLQLIPVSEVAAKDEFTGIKSVTRDDMLASLRTPPQLLGIVPQNSGGFGSIREAAMVWSAMELAPLQTRMTAINEWLGQDVIAFDPFELAPAA
>NC_010943.1|WP_044569400.1|327806_329564_+|terminase-ATPase-subunit-family-protein
MTSVAEQLHVDPRRQAKFLYWMGWRVCDIASLIGEKERTVHSWKARDEWDRADTVERIGGALEARLAILIHKEGKTGGDFKEIDLLHRQLERQARIQRYQGGGNESDLNPAVANRNAKPKKKARKNEFSEEEIERLQTAFVDGCFDYQRDWYRAGNERTRVILKSRQIGATFYFAREALIDALTTGRNQIFLSASKSQAHIFLGYMRGFVREVLDRDLTGDPITLANGAELFFLGTNARTAQGYHGNFYFDEFFWTYGFNQLNKVASGMAMHKKWRKTYFSTPSTMAHEAFDFWTGDRFNKGRPVSQQIQLDVSHARLMGGRRCEDAIWRQIVTVLDAAGRGCDLFDIEELRRDYSAEEFANLLMCEFVDDSASIFPLTMLQPCQVDSWVEWVDDFKPLAIRPYGDRAVWIGYDPAETGDSAGIVVVAPPLVPGGKFRVLERHQFKGMDFAAQAAFIQQVTLRYWVTYIGIDATGMGTGVAQLVRQFFPGVTIFNYSPEVKTRLVLKAFDVIKNERLEYDAGWTDLTQSLLAIQKTITPSGRQVTYTAGRSRTTGHADLAWALMHALQNEPLEGGTAARGSMEIF
>NC_010943.1|WP_148272144.1|326788_327703_-|GPO-family-capsid-scaffolding-protein
MGHHIENRCAPTPAEGEMATKNKKRSEFFRVAVEGATTDGRVIDRQQIVEIAETYNPEVYGARIWMEHIRSSLPDSPFRAYGDVVAVKAEEVDIAGKKKLALFAQVEPTDDLVEIVNSRKQKVFTSIEIAPEFADSGKAYLFGLAVTDSPASLGTSMLAFSAKHPEDSPLKDRKQAPENLFTEAAETTINFTTAEPASARPGPVATLLSTLGIGKKPAPVPPAKDEIDFDVGAFADQLMEAVGEQDAAMARLAQDNRALREQVQALSTQVASFRKKLDETPQGFTQRPVITGGKDVDAKNVTDC
>NC_010943.1|WP_012478858.1|325738_326755_-|phage-major-capsid-protein,-P2-family
MRTETRRLFDGFTQQIATLNNVSGVVNTFAVEPTVQQALEARMQENSTFLQAINMPGVAELKGEKIGVGINGTIAGRTDTSGNGERNPSDPTALDAQGYECQKTDFDTALPYARLDAWAHRPEFQTLIRDAIIQRQALDRIMIGWNGTSIAKNTDRVANPLLQDVNKGWLQKYREHAPERVMKEGAAGSGKIKVGGTDADYGNIDALVMDLVANLIDPWHQDDTSLVVICGRSLVHDKYFPIVNGNNTPTEKVAAELILGTKRIGGLQPVIVPFFPAKSLMVTSLSNLSLYWQIGGRRRHIMEQPNKNRVANFESSNDDYVIEDYGLGAIAENIEFGE
>NC_010943.1|WP_012478857.1|325027_325735_-|terminase
MADTPASRHLKRVLAEQSAAAVAGSNLMEGTTIYQQMQLRLAHDRARLKQIQSTQAKATLKVTLLPDYAPYVEGVLAANQGGEDQIVSTVMLWSMDAGEYHRALDIAEYVLAHGLSMPDEFSRTAGCVVAEEIGVAALNALKTGVEFDPAVLTRAMELTEGQDMPDQVRARLLLARARGLLPPDTEATPLDAEGVAQAVEDLRRAIQLHDSCGGKEDLKRAERLQKKFEASQSND
>NC_010943.1|WP_012478856.1|324455_324923_-|head-completion/stabilization-protein
MSSFTANASPVATQPPVTAGAFWPEIDVAVLREAIRVPGDVTQQRMRATVVMAVMSVTGELEQWQADKEAAGYATLAEVPARLIDDTSRLVQLYLRAVYCATAVELHERYRAYDATAQGNQRADDLSPTIDEMRRDQRNAISDLLGTRRVTVELI
>NC_010943.1|WP_012478855.1|324240_324456_-|tail-protein-X
MRVVALQGDTIDALCHRHLGTTAGMTEKVMALNYGISLHGPVLPMGTVVELPDVPTTSTGAVMRPLVQLWD
>NC_010943.1|WP_049886003.1|332896_333241_+|hypothetical-protein
MPLPPDFYWTTRSASWPGDPLTVIACDSVWVVAMSQRFDDGIWIALLDRHRNGPGGPARRCTSYEQACAGAELWVARHEARLREDVAAINRWREVVRANRLAKLNTPPPFGWMG
>NC_010943.1|WP_012478865.1|333315_334077_-|NYN-domain-containing-protein
MPTAILIDGGYFVKRFRRIEPHNALNANRAAELAHRWALAHLKSPSGDKRDLYRIFFYDCPPLTKKMHNPISGKCIDYSQSSEAVFRTALHDKLRHMRKVALRLGHLTEFSSWTAAPETLDALLKGRKSFADLTPDDLYPNVRQKGVDMRIGIDISSLALKRQVRQIILMAGDADFVPAAKLARREGVDFVLDPMWSKTPKGLIEHVDGMRSVCPKPPARAAKAVAPNAPGVENLPVVAEVAGAGAAANQPQA
>NC_010943.1|WP_012478867.1|334914_335202_-|hypothetical-protein
MTVSVIVFEPFKNDDKLAGFEHELELRTESHHRFADNVIFAKHEGSTRGLYDALKAAGQMTGLVLIEAKEVQDSSWIVDGQAFDWLNGALPNYKV
>NC_010943.1|WP_012478868.1|335567_336692_-|hypothetical-protein
MERTEDAGLPQPQEGGRPGAARRPASPLDDPSLAPLLAKSPTLQAGLAQARREGIVVQWGTAGEGTYLVPGVKIVIDENAIGQGTRLARSLSHEVGHHLFTEPSNRASKQAYVDSELRGEAAATLSNVQVQREIVAGGGPDIGVSGTGSRPQQYGTIAAELQAGRINRSQALGQIAEVFKTEAPSVGPHATYELYYGDFYDREIAPTQRRRRPDPEFDAERTAVAASLSSTTDDSLSLQRATFSVAELGNADRSLYMQIRAGVERLDAESGKQWDESSQRMSASLLVLAKEQGLSRVDHVVLNNPTESLARGEKVFIVEGAMDDPAQRRGTMSTMDALRAPEAESLHRAEALAADLEQQPAQQVHAQDGLSFSR
>NC_010943.1|WP_012478869.1|336719_337319_-|hypothetical-protein
MNAWVEKCATSSERGLRRRLWIAARRRLAIAIPALVLAACSTAAPPRPSDHLNQRQAVESGSEIGMERFKNSIERLSTVRFDDVDALSELLHTRLGEPARQDLMDERIAERGMLGDLEVRNIRLRSAADNPALANLIFDIAPPSIALEEMIWENSTKHPPRPDAPGSRPYWTAQVNDAQVVLGLAADSVTLTYISIRQH
>NC_010943.1|WP_012478870.1|337552_337840_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLGDGISELRIDAGPGYRLYYTQRGRQLLILLVGGDKSSQQRDIEKAREIARAL
>NC_010943.1|WP_012478871.1|337898_338201_+|putative-addiction-module-antidote-protein
MATKKKVELKSFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPDFATILKVTRALGVRLHASAV
>NC_010943.1|WP_012478872.1|338258_338582_-|hypothetical-protein
MSTPYPDLKPFLVELRLDEVDSRGGTVAEMIASTARPRALSISPGVMWYSFVLNDRVVTRITPGTRAHCTISFVNHDGAKEVFPCGTVAAFGDGSSTRGLIRIIRFD
>NC_010943.1|WP_044569408.1|338661_339069_-|hypothetical-protein
MPKTHHPYLTATLGEAALRLPPELAQPLEAAFAAANEAPAPINLPGCLQRIQAGDAADGQPWPGPSTTPGQAVAAARRDRAAVGLVSLLELYHAAERVRVDGEEKDDIGDGTREGLMLACRGLAEYVALQMGGTQ
>NC_010943.1|WP_012478874.1|339662_340433_+|DUF3011-domain-containing-protein
MRRHALPLTVALLSAAFAAPAMAAVPFFNASCPGGIDVHADDGGPVYVQGREATLKRFNDRYFEARDANSGITLSISRNDDGAPQVSYTGRGGANGICQVSASGTSALTANSARPRDAAAGDAALPREVTCESTDQQQVSCDLNTRGNVEIVRQLSRTRCEEGKNWGLSRHSVWVNGGCRAVFRNTSRMSYSAPTGDSALGACNLRKGAQGAVVTQVPVGSDYQELIIDYPDGRYLCMMRNNGEVQSVTPLRRRGG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_010943_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010943_3

586645-586746

Orphan

Consensus_repeat	Method
GGTAGGTGCCGACCGTTGGTCGGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010943_3

>merge|NC_010943|3|586645-586746|CRISPRCasFinder
GGTAGGTGCCGACCGTTGGTCGGCAGACCCCAATGCCCCGGTGGGTGCCAACCTTGGTTGGCACTCTTTACTGCCCTGGTGGGTGCCGACCGTTGGTCGGCA

>NC_010943|3|3|586645-586746|CRISPRCasFinder
GGTAGGTGCCGACCGTTGGTCGGCA	GACCCCAATGCCCCGGTGGGTGCCAACCTTGGTTGGCACTCTTTACTGCCCT
GGTGGGTGCCGACCGTTGGTCGGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_010943.1\|WP_012479027.1\|580641_581205_-\|DUF3016-domain-containing-protein	unknown	unknown	gnl\|CDD\|378666
NC_010943.1\|WP_012479037.1\|593625_594282_+\|phosphoglycolate-phosphatase	unknown	unknown	gnl\|CDD\|237310
NC_010943.1\|WP_012479034.1\|591095_591734_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|225462
NC_010943.1\|WP_012479033.1\|590045_590957_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293825
NC_010943.1\|WP_005407927.1\|585260_585962_+\|pseudouridine-synthase	unknown	unknown	gnl\|CDD\|211327
NC_010943.1\|WP_012479030.1\|585958_586642_+\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223710
NC_010943.1\|WP_012479036.1\|592768_593560_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NC_010943.1\|WP_005407919.1\|577479_577959_-\|Lrp/AsnC-ligand-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|183009
NC_010943.1\|WP_012479032.1\|588671_589766_+\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035
NC_010943.1\|WP_005407930.1\|587965_588481_-\|3-hydroxyacyl-[acyl-carrier-protein]-dehydratase-FabA	unknown	unknown	gnl\|CDD\|179953
NC_010943.1\|WP_044569475.1\|577187_577370_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012479029.1\|584199_585264_+\|methyltransferase	unknown	unknown	gnl\|CDD\|225370
NC_010943.1\|WP_012479035.1\|591842_592772_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NC_010943.1\|WP_012479031.1\|586757_587966_-\|beta-ketoacyl-ACP-synthase-I	unknown	unknown	gnl\|CDD\|181184
NC_010943.1\|WP_005407924.1\|583407_583698_+\|DUF3247-family-protein	unknown	unknown	gnl\|CDD\|371627
NC_010943.1\|WP_005407925.1\|583780_584044_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012479038.1\|594381_596223_-\|TonB-dependent-vitamin-B12-receptor	unknown	unknown	gnl\|CDD\|273802
NC_010943.1\|WP_012479026.1\|579391_580459_+\|alanine-racemase	unknown	unknown	gnl\|CDD\|143500
NC_010943.1\|WP_005412127.1\|578108_579413_+\|D-amino-acid-dehydrogenase	unknown	unknown	gnl\|CDD\|234819
NC_010943.1\|WP_005407938.1\|596704_597283_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010

Protein	Function_ID	Function_description	E-value
NC_010943.1\|WP_012479027.1\|580641_581205_-\|DUF3016-domain-containing-protein	gnl\|CDD\|378666	pfam11454, DUF3016, Protein of unknown function (DUF3016). This is a bacterial family of uncharacterized proteins.	1.16679e-64
NC_010943.1\|WP_012479037.1\|593625_594282_+\|phosphoglycolate-phosphatase	gnl\|CDD\|237310	PRK13222, PRK13222, N-acetylmuramic acid 6-phosphate phosphatase MupP.	5.6251e-85
NC_010943.1\|WP_012479034.1\|591095_591734_-\|NAD(P)H-binding-protein	gnl\|CDD\|225462	COG2910, COG2910, Putative NADH-flavin reductase [General function prediction only].	1.07738e-67
NC_010943.1\|WP_012479033.1\|590045_590957_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293825	cd07739, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.54897e-98
NC_010943.1\|WP_005407927.1\|585260_585962_+\|pseudouridine-synthase	gnl\|CDD\|211327	cd02553, PseudoU_synth_RsuA, Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.	4.64966e-75
NC_010943.1\|WP_012479030.1\|585958_586642_+\|HAD-family-phosphatase	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	1.64639e-59
NC_010943.1\|WP_012479036.1\|592768_593560_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	4.12959e-17
NC_010943.1\|WP_005407919.1\|577479_577959_-\|Lrp/AsnC-ligand-binding-domain-containing-protein	gnl\|CDD\|183009	PRK11169, PRK11169, leucine-responsive transcriptional regulator Lrp.	2.38136e-70
NC_010943.1\|WP_012479032.1\|588671_589766_+\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
NC_010943.1\|WP_005407930.1\|587965_588481_-\|3-hydroxyacyl-[acyl-carrier-protein]-dehydratase-FabA	gnl\|CDD\|179953	PRK05174, PRK05174, bifunctional 3-hydroxydecanoyl-ACP dehydratase/trans-2-decenoyl-ACP isomerase.	3.90362e-120
NC_010943.1\|WP_012479038.1\|594381_596223_-\|TonB-dependent-vitamin-B12-receptor	gnl\|CDD\|273802	TIGR01779, Vitamin_B12_transporter_BtuB, TonB-dependent vitamin B12 receptor. This model represents the TonB-dependent outer membrane receptor found in gamma proteobacteria responsible for translocating the cobalt-containing vitamin B12 (cobalamin). [Transport and binding proteins, Other, Transport and binding proteins, Porins].	0
NC_010943.1\|WP_012479029.1\|584199_585264_+\|methyltransferase	gnl\|CDD\|225370	COG2813, RsmC, 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis].	7.21177e-67
NC_010943.1\|WP_012479035.1\|591842_592772_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.37725e-85
NC_010943.1\|WP_012479031.1\|586757_587966_-\|beta-ketoacyl-ACP-synthase-I	gnl\|CDD\|181184	PRK07967, PRK07967, beta-ketoacyl-ACP synthase I.	0
NC_010943.1\|WP_005407924.1\|583407_583698_+\|DUF3247-family-protein	gnl\|CDD\|371627	pfam11607, DUF3247, Protein of unknown function (DUF3247). This family of proteins is the protein product of the gene XC5848 from Xanthomonas campestris. The protein has no known function however its structure has been determined. The protein adopts a Lsm fold however differences with the fold were observed at the N-terminal and internal regions.	2.08818e-23
NC_010943.1\|WP_005407938.1\|596704_597283_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	8.42842e-35
NC_010943.1\|WP_012479026.1\|579391_580459_+\|alanine-racemase	gnl\|CDD\|143500	cd06827, PLPDE_III_AR_proteobact, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases. This subfamily is composed mainly of proteobacterial alanine racemases (EC 5.1.1.1), fold type III PLP-dependent enzymes that catalyze the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. hese proteins are similar to other bacterial ARs and are fold type III PLP-dependent enzymes containing contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity.	0
NC_010943.1\|WP_005412127.1\|578108_579413_+\|D-amino-acid-dehydrogenase	gnl\|CDD\|234819	PRK00711, PRK00711, D-amino acid dehydrogenase.	0

>NC_010943.1|WP_012479030.1|585958_586642_+|HAD-family-phosphatase
MTTIAALPFLPDAVIFDMDGLMIDSERVSLACWSQAADEFGLGLDEAVFLRMVGLGDRDTHALLRAQGIEDSVIEAVAARCHDLYEARTQTGLPLRPGILELLELLKAHAVPRAVATTTRQPRANRKLAAAGLLPYFDAVITSGDVARPKPAPDIYLLAAQRLGQAPERCLALEDSPAGTRAALAAGMTVIQVPDLVHPDEELRALGHRIVGSLVDAHALLLPLLPR
>NC_010943.1|WP_005407927.1|585260_585962_+|pseudouridine-synthase
MKLVKLIANLGYGSRKQVQWMFREGRVTDADGEVLYADDQVPHEAIRVDGEPLDPPVGLSIALHKPAGYTCSTKDTGRLIYDLLPPRFRDRDPVLSTVGRLDRETSGLLLLTDDGGLLHRIISPKSKLPKVYEVELSDDLRGDEVALFASGTLMLESEKTPLLPAELEVLDARRARLVLHEGRYHQVRRMFAATGNHVQALHRSRVGGLDLQGLDEGQWRQLTSTDLDTLFAP
>NC_010943.1|WP_012479029.1|584199_585264_+|methyltransferase
MASSDDAPLQTLFLPFSQGALRWPEGPVAFLRARDGWPLREVAGNREVHCEQSFAPFAQPLQQAAGWTVSGQLDDVAGKGRYPLVLVLPPRQREEARALFARALALVADGGRIVACQSNNEGARSGEGDLKQLTGLGGSLTKNHCRVYWTAPMQGQHDADLAKRWLALDAVRPIVGGRFLSRPGVFAWDRIDPASALLAEHLPADLAGRAADLGAGYGYLSRELLERCPKITALDLYEAEQRALALAELNLAPPPRPLPLRFLWQDVTAGIEPGYDVIISNPPFHTPSRADRPDIGQRFIAVAAQALRPGGRLYVVANRHLPYEYTLNESFGAVRVIAERDGFKLVEAVKGKGK
>NC_010943.1|WP_005407925.1|583780_584044_-|hypothetical-protein
MRALFVGGVVDNSEMDLEGSHPPVHYPEDTGGGHSRYRLHQVGHGADGSVAYAVYGAPDLADDEVARVAEERAYARRFEATPTLFEH
>NC_010943.1|WP_005407924.1|583407_583698_+|DUF3247-family-protein
MSRIAPRIHTDPAQIARLEALLPQLDGETQVELILHDGRRLLGTVAVRPTVQQYRNVAGDEGSNGQLRVDDYDTPVQQHHVWLDEIASIRRLPPRV
>NC_010943.1|WP_012479027.1|580641_581205_-|DUF3016-domain-containing-protein
MKRALVIALLAGALVVSGANAAARNVTGRDAPRALQANGPVSVKWEDPATFTEIRQSTNRFEAERGDWVQQLARYLQTTAAKPLQPGQTLDVTLVDIKRAGDYEPWHGPRARDIRVMRDIYPPRITLQYTLKDADGRIVSEGDARLSDSGYLQGSGLLTNSDPLRYEKRLIDDWVKRQLASQATAAR
>NC_010943.1|WP_012479026.1|579391_580459_+|alanine-racemase
MRPARALIDLGALRSNYRLARELGGGKALAIIKADAYGHGAVRCAQALEGEADGFGVATIEEALELRQAGIRAPILLLEGIFELSDMALVAEHDFWFAVGSPWQLEAVAAFDSPRPLTVWLKLDSGMHRLGLDVDSFRAAHARLSALPEVERIVLMTHLARADELDSERTHEQAATFARAIDGLHGETSVCNSPALLGWPDVRSDWVRPGLMLYGANPLPDDNTLTERLRPVMTMQSKVIAERWIEAGEPVGYGARFVAKARTRVGVVALGYADGYPQFAPNGTPVLIDGQPGALIGRVSMDMLTVDLTAHPQAAVGSVVELWGSAPTLAELAPRCGVSAYQLPCAVKRVAKVYV
>NC_010943.1|WP_005412127.1|578108_579413_+|D-amino-acid-dehydrogenase
MRVLVLGSGVIGTTSAWYLRQAGFEVTVIDRQPGPALETSFANAGQLSFGYTSPWAAPGVPKKAIGWLFEKHAPLAIKPGMDLAQYRWLWQMLRNCTHERYAINKARMVRMSEYSRDCLNELRAQIGIEFEGRDLGTTQLFRTQQQLDASAQDIEILAQYGVPYEVLDRAGIIQAEPALAHVDGLVGALRLPRDQTGDCQLFTRRLAQMCVDAGVEFRFDQDITGLEFDGDRITGVRIDGKLETADRFVVALGSYSPALVAPLGMRLPVYPLKGYSLTLPITDPAMAPTSTILDESYKVAVTRFDDRIRVGGMAEVAGFDLSLSQRRRETLELVVSDLYPKGGDLSRAQFWTGLRPATPDGTPVIGATPFRNLYLNTGHGTLGWTMACGSGRYLADLMSARQPQISTEGLDIFRYGQYGHAPQQENRTCVLPAR
>NC_010943.1|WP_005407919.1|577479_577959_-|Lrp/AsnC-ligand-binding-domain-containing-protein
MATRTRELDKIDRKILRILQAEGRISFTELGERVGLSTTPCTERVRRLEREGVITGYHAHLDPAAVKASLLVFVEISLAYKSGDIFEEFRRAALKLPNVLECHLVSGDFDYLLKARISEMASYRKLLGSTLLTLPHVRESKSYIVMEEVKETLSLPIPD
>NC_010943.1|WP_044569475.1|577187_577370_+|hypothetical-protein
MSFVHWIAIMKNQQNRHPGKEPQGRNPQQQQQQQQQMDPQQPHKGGKQQEQRSQKHPQQR
>NC_010943.1|WP_012479031.1|586757_587966_-|beta-ketoacyl-ACP-synthase-I
MRRVVITGMGITSCLGNDLDTVSAALREGRSGITALADHAEAGLRSQVGGRVDLDLEALIDRKQKRFMSDAAAFAYLAMRDAIADAGLSAEQVSSLRTGLIAGSGGGSSEWQIGAVDLLRERGVRKVGPYMVPRTMCSTVSACLATAYQIKGVSYSLSAACATSAHCIGAAADMIRHGAQDIMFAGGGEDLHWSMSVMFDAMGALSTSFNETPASASRPYDKDRDGFVIAGGGGMLVLEDYDHAVARGAHIHAELIGYGVTSDGADMVAPSGEGAVRCMKMALQGVDRPLDYLNTHGTSTPLGDVTELNAIREVFGDAVPPLSSTKALSGHSLGAASVHEAIYCLLMMRDGFVAGSANIGELDPKVESFPILRESREQKLDTVMSNSFGFGGTNAALVFGRV
>NC_010943.1|WP_005407930.1|587965_588481_-|3-hydroxyacyl-[acyl-carrier-protein]-dehydratase-FabA
MTRLHAFNREQLLASARGELFGTAAGRLPNDPMLMFDRITDIREDGGPHGKGMVRAELDIRPDLWFFGCHFIGDPVMPGCLGLDAMWQLTGFFLTWLGAPGKGRALGCGEVKFTGQVLPEAKLVRYEIDISRVINRKLVMAQSDARMYVDDREIYSARDLRVGLFTETGSF
>NC_010943.1|WP_012479032.1|588671_589766_+|DNA-polymerase-IV
MTRLRKIIHVDMDAFYASVEQRDDPSLRGKPVVVAWRGARSVVCAASYEARVFGVRSAMPAVRAERLCPDAIFVPPDFARYKAVSQQVRAIFLRHTDLVEPLSLDEAYLDVSEPKSGIELATDIARTIRAQIREETNLTASAGIAPNKFLAKIASDWRKPDGQFVIPPQRVDAFLAPLPVNRVPGVGKVMEGKLAARGIVTCGDLRQWALIDLEEAFGSFGRSLYNRARGIDERPVEPDQQVQSISSEDTFAEDLLLEDLTEAIVQLAGKTWNATRKTERIGHTVVLKLKTAQFRILTRSFTPERPPESMEELRDIALALRARVDLPAETRYRLVGVGLGGFREKEAVVQGELFEQGPNDSPRS
>NC_010943.1|WP_012479033.1|590045_590957_-|MBL-fold-metallo-hydrolase
MRTAALLLPLALAASFTSAPLLAAPATAAPAAATKSQLHLQTFHPGPQAMFSVSSVLIEGRRDAILVNAQFGASDARKLVELIRASGKQLTTIYISHGDPDYYFGLATLQDAFPQARIVATAQTVAHIQQTQAGKLAYWGPKMGADVPSRIVVPQVLDGDALQLEGQRLPLIGLDGPTPDRTVLWVPSLRAIVGGIPVVAGEHVWMADTQTPKSHADWLQTLQRLQALKPKVVVPGHYAPGAALDASALRFTADYIRAFDAEAAKAKDSAALVKAMQARYPKLAGVASLELSAKVAKGEMQWP
>NC_010943.1|WP_012479034.1|591095_591734_-|NAD(P)H-binding-protein
MKIALVGSTGNIGRQIARHALANGHELTVIVRSAQDLPAELAGAHPVIASLDDQDALVAAIAGHDVLASAYGPRPGDDIGRVGEVAAQLAAAARKAGVPRLVVVGGAGSLEVAPGVQLVDTPNFPEAYKPYALAHREAFNRLQAVDDLDWTFFSPAAEIGPGEERGQYRVQPKAFLADASGHSRISYADYGAAFVAELEAQQYPKQIITAAY
>NC_010943.1|WP_012479035.1|591842_592772_+|LysR-family-transcriptional-regulator
MDRLTAMTVFVEVAERGSLTAAAEVLDMSRAMVSRYLAEVEAWLGARLLHRTTRRVSLTGPGEAALARFRQMLAIGEELQGELASDDPEPHGTLRVTASVSFGQSHLARAVAAFVARHPAARIELLLVDRMVNLVEERVDLAVRIARQIDPSLIARRLATCRSVLCATPSYLQARGTPTAPEHLAAHNCLTHHYVGKSLWQLHRDGRSLSVAVGGNISANEASLLLEAVRAGAGIAMLPTYQVAPLLRSGELIELLPEFSLDELGIHAVYASRRQQPAIMRRFLDFLAECFASPAFQDLDWRPPGKENT
>NC_010943.1|WP_012479036.1|592768_593560_+|class-I-SAM-dependent-methyltransferase
MNHGQALIDHNRAAWDRQASEVREWSRPVESSTVAAAREGRWQVHLTPRALPLDWLGDVRGRRILCLASGGGQQAPVLAAAGAEVTVFDLSDGQLEQDRQVAARDGLQLRTVQGDMRDLHAFANDSFDVVFHPISNLYVPDVRPVWTECRRVLARDGMLMASFYNPVLFVGARDPQLDAQGLIRPQYAIPYSDLEDLPPAEREAKLARGDALTFGHSLTELIGGQLDAGFVIDRFMEDWQPQPRFLIDRYLPTFLATRARRIG
>NC_010943.1|WP_012479037.1|593625_594282_+|phosphoglycolate-phosphatase
MSYPYPLVVFDLDGTLVDSAADIAEALNRTLEDIGLARVPEATVLGWIGDGVRRLVEQAVQAAGREVDLAEVMPVFMVHYRECLLRSPRLFDGVGEALAQLRARNVPLAICTNKPEALVPPLLQHLGIGDAFALVLGGDSLPQRKPSGEPLRHIAAHFGLPVESCLMVGDSLTDYRAAEEAGMPIALVRYGYPRGLHLATAHAVAVIDDLRELPGLRG
>NC_010943.1|WP_012479038.1|594381_596223_-|TonB-dependent-vitamin-B12-receptor
MKLQSRMLSLAVLAALPALAQAANDTTALDQILVTATRTPIALQDSIAPAQVIDRAQIESSQATSLQELLRGRAGINLANAGGLGKQSSLFLRGTNSGHTVVLVDGVRINSADLGLAMYQDLPLAQIERVEIVRGPQSSLYGADAIGGVIQIFTRRNQGDFAPHFQLGGGSNGLREASGGIGGGTERGWFGADIAYQHSDGIDACRGSATLFAGCFADEPDRDGYRNLSKSLRGGYTFNDQWNVEGSALRADGRNHYDGYYNYSETRQQVLAGKVRYTPSERLAFTANVGRSDNESDNFGDFGARGSAQTHRDSASLQGDFGVAEGQLLSAGVDWSEDNLDGSSAGYLVDSRRNTGVFVQYQGRFGRHQLQASARNDDNQQFGNHATGSVGWAMELGHGLRLNASYGTAFKAPTFSDLYDPWSGVPTLKPEKSKSANLGVSQQGQGWHWGLDVYETRIDDLITYDAATFKMQQVEKARIRGAELTGGVLLAGFDINAQLSYTDPRNRTGGSTQFDNWLPRRAQQTARLDIDRRFGDFRAGLTVQGAGKRYDDAANAVKVGGYGTLDLRAEYALTPSWSLLARAANVFDRRYETVAWFNQPGREYQLSVRYQPK
>NC_010943.1|WP_005407938.1|596704_597283_+|histidine-phosphatase-family-protein
MILDLVRHAGNGRDEFLDGRSDPPQLAGLPQELVEAYAGQRWERVISSPRLRALHTAMALATPRGLDVEADEEWEELDFGDWDGRSLFDLPEDALAAFHADPHAFPPPNGESWGHFERRIARALDRLLDDDDPVPTLVVSHGGPLRMVLSQVCGLPMSLCWALRIDHGTRLRVWLERGEIGLVGELLELQQP

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Crispr_ID: NC_010943_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010943_4

749780-749864

Orphan

Consensus_repeat	Method
TGGTAGTGCCGGCCGCTGGCCGGCATCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010943_4

>merge|NC_010943|4|749780-749864|CRISPRCasFinder
TGGTAGTGCCGGCCGCTGGCCGGCATCGCGCCCAAGGTGGCAGGTGAATCACCATGTGGTAGTGCCGGCCGCTGGCCGGCATCGC

>NC_010943|4|4|749780-749864|CRISPRCasFinder
TGGTAGTGCCGGCCGCTGGCCGGCATCGC	GCCCAAGGTGGCAGGTGAATCACCATG
TGGTAGTGCCGGCCGCTGGCCGGCATCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_010943.1\|WP_005412223.1\|755725_756145_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_005408041.1\|739079_740114_+\|type-1-fimbrial-protein	unknown	unknown	gnl\|CDD\|226069
NC_010943.1\|WP_044569511.1\|734253_734619_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_010481992.1\|751289_752954_-\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NC_010943.1\|WP_005408051.1\|753867_755121_+\|serine-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234571
NC_010943.1\|WP_012479127.1\|749871_751188_-\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NC_010943.1\|WP_012479133.1\|758592_759021_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012479131.1\|756172_756622_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_005412212.1\|736524_739089_+\|fimbrial-biogenesis-outer-membrane-usher-protein	unknown	unknown	gnl\|CDD\|225729
NC_010943.1\|WP_005408042.1\|740381_741566_+\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	unknown	unknown	gnl\|CDD\|223458
NC_010943.1\|WP_012479124.1\|743770_745918_+\|glycosyl-transferase-family-protein	unknown	unknown	gnl\|CDD\|237974
NC_010943.1\|WP_004143350.1\|756771_757293_+\|transcriptional-repressor-NrdR	unknown	unknown	gnl\|CDD\|234774
NC_010943.1\|WP_012479132.1\|757471_758557_+\|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	unknown	unknown	gnl\|CDD\|182729
NC_010943.1\|WP_012479125.1\|745914_748734_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372547
NC_010943.1\|WP_005408038.1\|735078_735618_+\|fimbrial-protein	unknown	unknown	gnl\|CDD\|226069
NC_010943.1\|WP_012479129.1\|755245_755719_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012479123.1\|741562_743764_+\|cellulose-biosynthesis-cyclic-di-GMP-binding-regulatory-protein-BcsB	unknown	unknown	gnl\|CDD\|377001
NC_010943.1\|WP_005408039.1\|735703_736432_+\|molecular-chaperone	unknown	unknown	gnl\|CDD\|225663
NC_010943.1\|WP_012479128.1\|753206_753680_+\|RcnB-family-protein	unknown	unknown	gnl\|CDD\|378715
NC_010943.1\|WP_044569513.1\|748727_749732_-\|DUF4434-domain-containing-protein	unknown	unknown	gnl\|CDD\|373094

Protein	Function_ID	Function_description	E-value
NC_010943.1\|WP_004143350.1\|756771_757293_+\|transcriptional-repressor-NrdR	gnl\|CDD\|234774	PRK00464, nrdR, transcriptional repressor NrdR.	5.26754e-86
NC_010943.1\|WP_005408041.1\|739079_740114_+\|type-1-fimbrial-protein	gnl\|CDD\|226069	COG3539, FimA, P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion].	4.26571e-20
NC_010943.1\|WP_010481992.1\|751289_752954_-\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NC_010943.1\|WP_005408051.1\|753867_755121_+\|serine-hydroxymethyltransferase	gnl\|CDD\|234571	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed.	0
NC_010943.1\|WP_012479127.1\|749871_751188_-\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	5.00521e-169
NC_010943.1\|WP_005412212.1\|736524_739089_+\|fimbrial-biogenesis-outer-membrane-usher-protein	gnl\|CDD\|225729	COG3188, FimD, P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion].	0
NC_010943.1\|WP_005408042.1\|740381_741566_+\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	gnl\|CDD\|223458	COG0381, WecB, UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane].	2.97509e-150
NC_010943.1\|WP_012479124.1\|743770_745918_+\|glycosyl-transferase-family-protein	gnl\|CDD\|237974	PRK15489, nfrB, glycosyl transferase family protein.	0
NC_010943.1\|WP_012479132.1\|757471_758557_+\|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	gnl\|CDD\|182729	PRK10786, ribD, bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD.	5.71464e-134
NC_010943.1\|WP_012479125.1\|745914_748734_+\|hypothetical-protein	gnl\|CDD\|372547	pfam13283, NfrA_C, Bacteriophage N adsorption protein A C-term. The function of this domain is unknown but it is found at the C-terminus of bacteriophage N4 adsorption protein A, in association with an N-terminal region of TPR repeats.	5.04334e-24
NC_010943.1\|WP_005408038.1\|735078_735618_+\|fimbrial-protein	gnl\|CDD\|226069	COG3539, FimA, P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion].	4.26196e-22
NC_010943.1\|WP_012479123.1\|741562_743764_+\|cellulose-biosynthesis-cyclic-di-GMP-binding-regulatory-protein-BcsB	gnl\|CDD\|377001	pfam03170, BcsB, Bacterial cellulose synthase subunit. This family includes bacterial proteins involved in cellulose synthesis. Cellulose synthesis has been identified in several bacteria. In Agrobacterium tumefaciens, for instance, cellulose has a pathogenic role: it allows the bacteria to bind tightly to their host plant cells. While several enzymatic steps are involved in cellulose synthesis, potentially the only step unique to this pathway is that catalyzed by cellulose synthase. This enzyme is a multi subunit complex. This family encodes a subunit that is thought to bind the positive effector cyclic di-GMP. This subunit is found in several different bacterial cellulose synthase enzymes. The first recognized sequence for this subunit is BcsB. In the AcsII cellulose synthase, this subunit and the subunit corresponding to BcsA are found in the same protein. Indeed, this alignment only includes the C-terminal half of the AcsAII synthase, which corresponds to BcsB.	0.00540583
NC_010943.1\|WP_005408039.1\|735703_736432_+\|molecular-chaperone	gnl\|CDD\|225663	COG3121, FimC, P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion].	7.0472e-81
NC_010943.1\|WP_012479128.1\|753206_753680_+\|RcnB-family-protein	gnl\|CDD\|378715	pfam11776, RcnB, Nickel/cobalt transporter regulator. RcnB is a family of Proteobacteria proteins. RcnB is required for maintaining metal ion homeostasis, in conjunction with the efflux pump RcnA, family NicO, pfam03824.	5.53309e-11
NC_010943.1\|WP_044569513.1\|748727_749732_-\|DUF4434-domain-containing-protein	gnl\|CDD\|373094	pfam14488, DUF4434, Domain of unknown function (DUF4434).	2.76691e-23

>NC_010943.1|WP_044569513.1|748727_749732_-|DUF4434-domain-containing-protein
MVRPDLPADPSSPLRRRLLRAAVLAPLASMLATLPGCSLPVQVDGTFLQPWRSHLQWGLADWQRSLKLARTLGCRQLVLQWTGIVGGSDGDWSLPDGSLQQLFTAASENDIRIRVGLPFQQRWWQAIGADDATLQAFLADSLAHARNWLAQAPWAQQPAFEGWYLPYELEQYHWADPARQQWLAQWLHRLVEAASARGGDCAISCYFSRLQTDGNLVMLWQAVLAQATLRPMVQDGVGVAGAGNVQQLQPLLDHFHAHGIGFDAIVELFRELPGGPADGSGFKGETADAARIQRQLAWARDSGAQHVLVYALEPWLTQDTPQAAALRRRWGLPQ
>NC_010943.1|WP_012479125.1|745914_748734_+|hypothetical-protein
MKTTLLSTVITVALATAAAPVLAQTDAPLPLSGAAYRIAEQAFAAYERGDYPAAYRQSSEAIRLRPDVVRLRLLQIYALQKLGRGAEAQQQARRALDAGLKDPALPALAAAPRTRRGAARTGAVPRAPATVTDRNSRQAYMLATEAYAAYDAGQMGVAASKAEQAFRQQPQQGAWALLWVAALEAQQQPGQADAAIGTALQLGAPNVEELRARRVALGRQRALLLAQQAYQSLSAGENAAAIEQAHAAVELAPDVASYRLLLITAQLQGDQLADAEHSADAALQVDANDLNARVMRGYLRQRQGNTVLANEDFDTALAAPGSATQQRNVRLLAVDAALAAGDRVRAAALLAPLQAAVPAGEGDARSQQLLQQGIEQRSRAIRSSRELPRIGAEAYLAPVQHCQSVDSGSLCELMPADLQGDGGAAQRAYAAYARQDYADAIGEARQAVQLAPDDANLQGLLTTTLAAGNRAQQDEARQRLDAALAQRPDDAGALMQRGYLNQKAHEPARALADFRAAEATGKAPKSVVLDQAYASAANGDHPQAVTLLRSAIDRADAGELPLDERQRYNVRNAIANYSREWGVIASAGFRGARQAATNVGGAAISTPGDSVFSTLEAFWRPPAFNDQHGTLELYARLLNTLYDEGGTYESIRAVDPCTGESTPDARARAERLSHSRSTTGWPSTIASFGMRYAFGQTGLSAGLERRQFLGSATRQGEVYPASAAVQCRLQLARNPPLEASTLARYRLASDSGGWMSYLTYGYYHGIDLRTDVNQWWMVSGYAQGGYTWDDNSAHFTLDALDANGTPVRRIGDANGRLHREQWFAAGELRAGRSFRFGAGQTHWVVTPYVVVGADWLDQRSRVHDIRYPLFPAQSFALNDTQRSWSFGAGPGVGVRYWFREDHYNTPRSYLDLTVQYRFAIGGGDTQRAKGLFATAILYY
>NC_010943.1|WP_012479124.1|743770_745918_+|glycosyl-transferase-family-protein
MDGLFWNIQLANYYAVLESTAAAVAVLILISSLDDLFIDVWYWVRESWRALTIKRREAYRPLTQEDLMQRPQQPLAIMVPAWMEYDVIAQMVENMINVLDYREYVVFVGTYPNDQQTIDEVERMRRRYKRLRRVEVPHDGPTSKADCLNWLILAIFDYEKRHDIEFAGVILHDSEDVLHPMELRFYNYLLPRKDMIQLPVTSLDREWYELVAGVYMDEFAEWHAKDLVVRESVSGMVPSAGVGTCFSRRALLALSAQTDNQPFNTDSLTEDYDVGARLAAMGMQSIFARFPVQFRVRRPSWFGWGPVRERTQQMALCVREYFPDNFRASYRQKARWVLGIGLQSWESLGWRGSLATKYLLARDRKGIITSFVSIIAYIIFLQLLLFWLLKMTGLWTMQFPSVFQAGTWQMNVALLTTAALATRVVQRFYFVNRLYGWEHALMSIPRMVVGNMINFMATARAWKVFLAYLLFGKRMVWDKTMHDFPDAAQLVQTRKQLGELLTTWQAVEPERLQQALEQQQAGRQQPLGRILLTQGWLDDETLAEAIAFQGDLPRAVIDVDYLRACQFPISADACVQWRMLPLPPRQEGTLRLAVASPLPEDALALLKQETRSNHIEQSIARESEINAGLRLIGGDRQWQLDTVPLLGDLLVEMRLIDHARFEIALDDYMPQRDGRIGDYLVKQGITTEEAVAQAMQEQRRRAATLQSPPPGALPA
>NC_010943.1|WP_012479123.1|741562_743764_+|cellulose-biosynthesis-cyclic-di-GMP-binding-regulatory-protein-BcsB
MTQTGRSPLFASAAAFVLSGVVGSAHAADSVAGQFAEWSGDSTVSRQMTLRELGFRQPLVLSGQESQREIYLPVPAGVATRDAQLQLDGRYVRGHAGRTSGLWSVDGDPIAARSITDAQGDASQLLAIDGEPRQNGFVRVGVGWWSIVSDYQCADQSAPANVLRLSPDSRFSYRFDGRAVDTVAKAWGALPPQVRLLVDGKALQAPIYDAAWRIGAALQAGGKQVQVVALPKVGDSLDLTGISIPASLQGVPAYAALAAGERAHAIKDLAEVGALLSLRDSGPLAADVMIGSDALRAGVRTALDALAAQVATAGADAGTAFAAWRGTDMGGLEKPAATASVSVVAVAGRPTLVVDPPAAGKVAGLFAEQWRSYALGRSLQVSAAGTPKLDGDQVLLSRLGNIAGTVDVVTRADRSASFDLGALSADGRLPEEVVIDVSAAPNAAGQGAVATIHFNDYLLGGKVLSANGQPQRLVAKVPAYALSARNEIRVSFLRQPARPYCHDPATAYPVSILPSSHLTLAKRSLGSDFVGASSQLSRGNQMFVPATWLQDAPASLRKVIAVASAVGASPEASELKVVDAGAAISPGAPWLAFGVAPSGVDVAGLKDGHLLIGGKPQPLLDVSGLDRAAVVQVGTSGGQLGVLYSDLGAQAPSFGAPFRLLRGDLAVLDGSDAVREFDRQDPYGGRVAQDGNPQSKWERHMVWLLLLVGVIVFALLAARVTQVRRRKSANTGH
>NC_010943.1|WP_005408042.1|740381_741566_+|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)
MKVLSVFGTRPEAIKMGPLVRALAEAADIESVVCITGQHRAMLDQVMSLFEITADHDLDVMVPNQTLNGLCSRLFERLDALYTQVRPDRVLVHGDTTTAMTAALAAFHHRIPIGHVEAGLRTGDINRPWPEEMNRRVIDVVGDQLYAPTPSSRANLAGEHLGGQILVTGNTVIDALQQTVERLDADPALRARADEPFHMLDPDRRLLLVTGHRRESFGQGFEDICRALAELARRPDLQVLYPVHLNPNVQGPVNAHLGHLDNVHLVPPQDYLRFVRLMQRADVILTDSGGVQEEAPALAKPVLVMRDVTERPEAVEAGVVTLVGTAPSRIVEAVNAALAQPPHPTRFDPHASPYGDGRASARIVAALRGTPLPEFSPGLRSSGAVHPHPREVTP
>NC_010943.1|WP_005408041.1|739079_740114_+|type-1-fimbrial-protein
MPMISSRGRKALSAVAILAGIAVASPALATCYITQQGFVAQDVQMDMGQIVILPSLPVGGVIKELIVPINQRDSIGYCDRWGGSANGRFVNAAQQNAVPGFSNVYATDVAGVGIRVYRDSGTIQTYYPHTLQLGGSRTLTLNGGRFRVELIKTAAQTGSGIIAPNGRFTTYYLDGDGPGRPELTSTFKGSGTTVVSPTCEVQAGSRNIAVDFGSVPNTTFTGVGSKAVDRDFEIRLNCQGSNVAQYQSKIGIRLDADQDSSNMPGVLKLSAATNSATRIGIQMVQRDGTTEREVRFGQTVNVGTTTPGTSTMTLPLRARYVQTQAGTVGAGVANGQATFTIQYE
>NC_010943.1|WP_005412212.1|736524_739089_+|fimbrial-biogenesis-outer-membrane-usher-protein
MSIHQALCLLVAGVACPGWALAAPANLGEQALMAQSGAANARAPESAQFNSSFLSGQAKQVDLAAFSNGNPMVAGNYRVDVYVNGAWQGRRDLQFKADAQGRVDACLPLPMLEEMGVDSEAVLLQQDPSVPTDKTSCVPVQQRMANAYGVYDSGNLRYDLSIPQVFLRREARGYVNPALWDRGINAGFVGYSFNAIDSDSRVEGGQRNRSAYLGLNAGMNLGGWQFRHDSNLTWSEGDGRHWQSIATYAQRGIPQVRGMLTIGEAYTTGELFDSIGYRGASLASDDRMLPDSLRGYAPVVRGIAETNARIEVRQNEQLIYSSTVSPGSFVIDDLYPTGYGGDLEVSVIEADGRRREFKVPFGSVPQMLREGVSRYSLTAGQVRNKLLADEPWLVQGTYQRGIGNQLTLYGGSALSDGYLSLLYGVGLSTPVGAFAADVTHARTSFDHYGNHTGASVRLSYSNMIGETGTNLTLAAYRYSTEGFYSLQDALYGRDSDKRGIDPTTRGRQRSQFQVTLNQPLGRRGGALYVTGSVRDFYDRSGTSKQYQVGYNNAWRSVNYGFSALRTEEGVLGRSDTQYLLSMSVPLGRGSHPVSFSADLGVRDRGGYDNSRVGITGSAGVDNNFSYGVALSDSREGGTTAVGNAEYRSRYSALNATYSHSRDFRQASVGANGSVVVHPGGFTFTPQRGDTMVLVEAPGARDAIVSNAPGLRVDGRGYAVVPYVSPYRLNTVTLDPQGMAHDVELESTSQSIAPFAGAISYLRFDTRKGNALLIQVRNPDGRTMPFGAQVKDEQGQPVGMVSQGGRLYVRSEKNQGRLLVEWGAGADQRCTVDYQVPAGADASKTGFIPLEAACR
>NC_010943.1|WP_005408039.1|735703_736432_+|molecular-chaperone
MKAFFPRALLLAAFTLPFCQNALAGVVVNGTRVIYPAQAREVTVQVDNVGDSPALVQAWIDSGDANQTADTSDAPFVLTPPIARVEPGRSQALRLIFSGAQLPTDRESVFWLNVLDVPPSPDNADSGEQNYLQVAFRSRLKLFYRPQGLKGVANDAPAALRWTRNGDRLRVENPSPFHVTLAEVHAVTGSSEKAVEDKGAMVAPKQSLEFAAPAGTDQVRFITINDYGGRVEHTIRLGSTGG
>NC_010943.1|WP_005408038.1|735078_735618_+|fimbrial-protein
MHKINLIAALMLAAAPLAANAADGTITFNGKVTDKTCTISTPGGKDFAVNLPTVSKNTLATAGAVAGRTPFAINLTKCSAGNVATYFEPGSTVDFNTGRLLNQASANAATNVQLQLLGSNNQVLPIKAAGAGLAQTNSQWVTVGTDGSADLNYYAEYYATAAATPGDVTSSVKYTIIYN
>NC_010943.1|WP_044569511.1|734253_734619_-|hypothetical-protein
MRTSLLLCVALMSVSALAQASSGSIRFSGRIAEPGCTTNLSQGELSLAACPPSAKGSTVAVTALADGQAATLRDGKRQGQKLSVSASAMRAGDIAFSERYSVQASKQQPLQGAYLVVVDYL
>NC_010943.1|WP_012479127.1|749871_751188_-|NCS2-family-permease
MSLFERLFQLQQHGTTVRTELLAGVTTFLTMSYIVFVNPEILGTTGMDAGAVFVATCLAAALGSAVMALAANFPVGMAPGMGLNAFFAFTVVGAAGLPWQQALGAVFISGLVFLVLSLTGVRAWLVSGIPSSLRSAIVAGIGLFLAIIALQKSGVIVGNEDTLVALGPLNTAPPLLALAGFLLIAVLEARRIRGAILIGILAVTGAGWALGDVQYQGLVSLPPSLSPTFLQLDLPGLLHHDGGAPIAVLLQVVLVFVLVEVFDATGTLYGVVGRAGLLKLPGAQKRFGRALLADSTAIVAGSMLGTSSTTAFAESASGVQVGGRTGLTALVVSALFLAALLFSPLAAMVPSYATAPALLFVAGLMLRELVEVDWSDLTESVPAALCALAMPFTYSIANGLAFGFIAYAALKAGTGRWREVHPAVWLVAVLFTLRYALE
>NC_010943.1|WP_010481992.1|751289_752954_-|energy-dependent-translational-throttle-protein-EttA
MSSQYIYTMNRVSKVVPPKRQIIKDISLSFFPGAKIGLLGLNGAGKSTVLKIMAGVDTDFEGEARPQPGIKVGYLAQEPELDPTKTVREAVEEGVGEVLQAQAALEAVYAAYAEEGADFDALAKEQERLEAILAAGDAHTLENQLDVAADALRLPPWDAVVGKLSGGEKRRVALCRLLLQKPDMLLLDEPTNHLDAESVEWLEQFLARYTGTVVAVTHDRYFLDNAAEWILELDRGRGIPWKGNYTDWLTQKDERLKQEDNQEKARQKAIQKELEWSRQNAKGGRTKGKARLARLEELQSVDYQKRNETNEIFIPPGERLGNAVMEFKNVSKKFGDRLLFDNLSFLVPAGAIVGIIGPNGAGKSTLFKMITGQEKPDTGEIVVGPTVKLSYVDQSRDALEGNHNVFQEIAGGLDILNINGIEIQSRAYIGRFNFKGQDQQKMVGSLSGGERGRLHMAKTLLQGGNVLLLDEPSNDLDIETLRALEDALLEFPGNTFVISHDRWFLDRIATHILAFEGDSHVEFFQGNYREYEEDKRRRMGDDAAPKRLRFKALK
>NC_010943.1|WP_012479128.1|753206_753680_+|RcnB-family-protein
MRINRVMASAVASVLALGAVAPAFADNDHRRDHDRREWREDRREWRQERRDWERDRREARRDWERDRRDWHRDHDRYYRPAPPRVVYRPAYGPGYGWKVGHRYRDYYRGPIYVVNDYPRYNLRRPPYGHQWIRDDRGNMLLVAIATGVIAQYVLSSR
>NC_010943.1|WP_005408051.1|753867_755121_+|serine-hydroxymethyltransferase
MFPRDVRIESYDPELAKAIAAETQRQEDHVELIASENYTSPAVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDIAEQLAIDRLKQLFGADYANVQPHSGSQANQAVYFALLQPGDTILGMSLAHGGHLTHGAKVNASGKLFNAVQYGVNDQGLIDYDEVERLALEHKPKMVVAGFSAYSQVIDWARFRAIADKVGAYLFVDMAHVAGLVAAGVYPSPLEHAHVVTSTTHKTLRGPRGGIIVAKGADEDLVKKLQSIVFPGIQGGPLMHVIAGKAVAFKEALEPGFKAYQQQVVKNAQAMANTLIERGYKIVSGGTQNHLMLVDMIGKDVSGKDAEAALGKAHITVNKNSVPNDPRSPFVTSGLRLGTPAVTTRGYVEQDCVDLANWIADVLDAPNDDAVIARVRDAVSAQCRKYPVYG
>NC_010943.1|WP_012479129.1|755245_755719_+|hypothetical-protein
MDERRLKYLYIALAVLFGLPSLFFGGAGACIAVVMGVIGLVSLDADKLWFAACMFAWGSCAIAGLVAWVALSIVWLRDGARGLHMASRRWWLLLGLGVLAGLPLLAMALYYFAELGSSVLSGLFAGPSLLVPTGMLILLRLRADALGEPSGPVRSKE
>NC_010943.1|WP_005412223.1|755725_756145_+|hypothetical-protein
MDERRLKYLYTALAVLFGLPSLVMGGAAATMLLLMGLGQFGHGTLASVTVMPLWGLAGIAGCLAWLWLSAGFLLQGRAGLQVRPVWWWMLLAGGLAALPPLGLALWWGIAVNAEGIGVLLLGPSMLVPAAMLLWIKRRA
>NC_010943.1|WP_012479131.1|756172_756622_+|hypothetical-protein
MDERLHKRWMAIAGLLVGLPTVAAGGTGAVLGLMVVWDGKYLTGDEHRLLLLWSSAGILGALSWLWLSGLFLWRGVTGLRHSPVVAWVGLGVGALAALGVVAATLYFTFKHGEISTLAFLGFGPPLLVMAGHLVWLRWARAASAPPAPA
>NC_010943.1|WP_004143350.1|756771_757293_+|transcriptional-repressor-NrdR
MHCPFCQHADTRVIDSRVSEDGATIRRRRECEACGERFSTMETVELKLPAIVKSDGTREAFDQRKVRAGFDRALQKRAVAEDKIEAAVRAVVHQLRISGEREVPSIKVGEFVMNELRKLDHVGYVRFASVYRSFEDVADFREEIEKLERDLPSSTEQLQLLGDVIALTKKKKG
>NC_010943.1|WP_012479132.1|757471_758557_+|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD
MTTSFSVLDHLHMANALRLAERAAYTTRPNPMVGCVIAHGERVVGQGWHQRAGGPHAEVFALREAGSEARGATAYVTLEPCAHYGRTPPCALALIEAGVSRVVAAMRDPFPKVDGGGFDLLRNAGIEVAEGLMAAQARELNKGFLSRVERNRPWLRVKLAASLDGRTAMADGSSKWITGPAAREDVQHWRARAGAILTGADTVLADDPMLTVRLADTEVMPPLRVVLDSRLRSLECGRVREGGAPTLYMHDAAVSAPDAADAEFASVPSAEGRLDLGAVLALLAERGINEVHTEAGATLAGALLRGGWMDELLLYQAPTLLGDNGRPLLAGLGINAMDQQRRLRVVDQRQVGEDIRLLLRP
>NC_010943.1|WP_012479133.1|758592_759021_-|hypothetical-protein
MVNAVALFHRGNRMKHRMTSIALMLLALMVCWQAEASRFKATRIFVVKPSVAFESTQLSDRHLDAWMSNDDHCRDFLMYHDQCAVLVLPDEYDDGFTRRQLRLKARQLPGETLGAYCRDLHVLWKQQWKGQCPVGEEDDEAA

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Crispr_ID: NC_010943_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010943_5

832011-832110

Orphan

Consensus_repeat	Method
TCATCCACGCATGGCGTGGATCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010943_5

>merge|NC_010943|5|832011-832110|CRISPRCasFinder
TCATCCACGCATGGCGTGGATCTGCCTCATTGAAAGGCAAACAAAAAAAGCCCGGGTGTCTGCACACCCGGGCTTCTTCATCCACGCATGGCGTGGATCT

>NC_010943|5|5|832011-832110|CRISPRCasFinder
TCATCCACGCATGGCGTGGATCT	GCCTCATTGAAAGGCAAACAAAAAAAGCCCGGGTGTCTGCACACCCGGGCTTCT
TCATCCACGCATGGCGTGGATCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_010943.1\|WP_005408112.1\|829812_830730_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176164
NC_010943.1\|WP_044571190.1\|834591_835563_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381369
NC_010943.1\|WP_012479180.1\|836268_838476_+\|TonB-dependent-hemoglobin/transferrin/lactoferrin-family-receptor	unknown	unknown	gnl\|CDD\|273808
NC_010943.1\|WP_005408103.1\|818933_820145_-\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NC_010943.1\|WP_012479176.1\|828128_829124_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NC_010943.1\|WP_012479173.1\|823130_824189_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|377294
NC_010943.1\|WP_005412278.1\|835883_836078_+\|hemin-uptake-protein-HemP	unknown	unknown	gnl\|CDD\|378463
NC_010943.1\|WP_005408115.1\|833099_834398_-\|nucleoside-transporter-NupC	unknown	unknown	gnl\|CDD\|224883
NC_010943.1\|WP_012479182.1\|840187_842704_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669
NC_010943.1\|WP_012479171.1\|820467_822183_+\|lysophospholipid-acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|153248
NC_010943.1\|WP_002811889.1\|844155_844869_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_010943.1\|WP_012479177.1\|829271_829703_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012479183.1\|843423_844068_+\|arylesterase	unknown	unknown	gnl\|CDD\|238860
NC_010943.1\|WP_012479175.1\|825254_827105_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_044569529.1\|839153_840080_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_005408109.1\|827243_828071_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181382
NC_010943.1\|WP_012479174.1\|824247_825258_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022
NC_010943.1\|WP_005408121.1\|842700_843348_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213222
NC_010943.1\|WP_005408118.1\|838480_839080_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226243
NC_010943.1\|WP_012479172.1\|822179_822980_+\|UDP-2,3-diacylglucosamine-diphosphatase	unknown	unknown	gnl\|CDD\|277343

Protein	Function_ID	Function_description	E-value
NC_010943.1\|WP_005408112.1\|829812_830730_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176164	cd08475, PBP2_CrgA_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 6. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.50983e-84
NC_010943.1\|WP_005408103.1\|818933_820145_-\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NC_010943.1\|WP_044571190.1\|834591_835563_+\|aldo/keto-reductase	gnl\|CDD\|381369	cd19143, AKR_AKR6C1_2, AKR6C family of aldo-keto reductase (AKR). Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.	0
NC_010943.1\|WP_012479173.1\|823130_824189_+\|metal-dependent-hydrolase	gnl\|CDD\|377294	pfam04307, YdjM, LexA-binding, inner membrane-associated putative hydrolase. YdjM is a family of putative LexA-binding proteins. Members are predicted to be membrane-bound metal-dependent hydrolases that may be acting as phospholipases. It is a member of the SOS network, that rescues cells from UV and other DNA-damage. Expression of YdjM is regulated by LexA.	9.51743e-26
NC_010943.1\|WP_005412278.1\|835883_836078_+\|hemin-uptake-protein-HemP	gnl\|CDD\|378463	pfam10636, hemP, Hemin uptake protein hemP. This is a bacterial family of proteins that are involved in the uptake of the iron source hemin.	2.47066e-16
NC_010943.1\|WP_005408115.1\|833099_834398_-\|nucleoside-transporter-NupC	gnl\|CDD\|224883	COG1972, NupC, Nucleoside permease [Nucleotide transport and metabolism].	9.89476e-142
NC_010943.1\|WP_012479182.1\|840187_842704_-\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	1.74428e-177
NC_010943.1\|WP_012479176.1\|828128_829124_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	2.53424e-147
NC_010943.1\|WP_002811889.1\|844155_844869_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.26547e-75
NC_010943.1\|WP_012479172.1\|822179_822980_+\|UDP-2,3-diacylglucosamine-diphosphatase	gnl\|CDD\|277343	cd07398, MPP_YbbF-LpxH, Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain. YbbF/LpxH is an Escherichia coli UDP-2,3-diacylglucosamine hydrolase thought to catalyze the fourth step of lipid A biosynthesis, in which a precursor UDP-2,3-diacylglucosamine is hydrolyzed to yield 2,3-diacylglucosamine 1-phosphate and UMP. YbbF belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.67343e-70
NC_010943.1\|WP_012479180.1\|836268_838476_+\|TonB-dependent-hemoglobin/transferrin/lactoferrin-family-receptor	gnl\|CDD\|273808	TIGR01786, hemoglobin-haptoglobin-binding_protein, TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein. This model represents a family of TonB-dependent outer membrane receptor/transporters acting on iron-containing proteins such as hemoglobin, transferrin and lactoferrin. Two subfamily models with a narrower scope are contained within this model, the heme/hemoglobin receptor family protein model (TIGR01785) and the transferrin/lactoferrin receptor family model (TIGR01776). Accessions which score above trusted to this model while not scoring above trusted to the more specific models are most likely to be hemoglobin transporters. Nearly all of the species containing trusted hits to this model have access to hemoglobin, transferrin or lactoferrin or related proteins in their biological niche. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	3.57532e-125
NC_010943.1\|WP_012479183.1\|843423_844068_+\|arylesterase	gnl\|CDD\|238860	cd01822, Lysophospholipase_L1_like, Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity.	2.2647e-86
NC_010943.1\|WP_005408109.1\|827243_828071_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	2.86608e-27
NC_010943.1\|WP_012479174.1\|824247_825258_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	4.67475e-43
NC_010943.1\|WP_012479171.1\|820467_822183_+\|lysophospholipid-acyltransferase-family-protein	gnl\|CDD\|153248	cd07986, LPLAT_ACT14924-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.	8.5976e-58
NC_010943.1\|WP_005408121.1\|842700_843348_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.38013e-97
NC_010943.1\|WP_005408118.1\|838480_839080_+\|hypothetical-protein	gnl\|CDD\|226243	COG3720, HemS, Putative heme degradation protein [Inorganic ion transport and metabolism].	0.00232894

>NC_010943.1|WP_005408112.1|829812_830730_-|LysR-family-transcriptional-regulator
MLPTERLRGIEAFVATADAGSFTAAAERLHLTSSAVGKTIARLEARLGARLFERSTRRLRLTEAGEGFYRTCVRVLGELADAESVLVSHADAPVGRLRVDAPATFGRLKVWPLLLQLAAEFPQLHPQVTFSDRFSDLAEDGVDLAVRIGGPEPLPATLGSRLLGYECLRFCASPAYLLRHGQPRSAAELAGHDGVLFGRADGSIGPWQVADGRQRSTPLQARARLVVGSAEAQVAAVEAGFGIAQLATWLVDDALARGSLVSILPSLDCRGLPLRLLWPQGRQRLPRVDVALDRLGAGLQIDPPR
>NC_010943.1|WP_012479177.1|829271_829703_-|hypothetical-protein
MDGFPWLLVAAAGSAIAALLHIGCIAFGAAWYRYFGAGQRMVRLAQAGHWWPPLMTAGITAVLVAWTLYALAAAGWHSPLPASRLVLSGIALLLLMRAAMGFGLALLRPGYNGRRFWVVSSVVCLSLGLAFALGTGQAWQSLR
>NC_010943.1|WP_012479176.1|828128_829124_-|tRNA-dihydrouridine-synthase-DusB
MQIGPYTIAPNVVLAPMAGVTDKPFRLLCKRLGAGLAASEMTISDPRFWNTRKSIHRMDHDGEPAPISVQIAGTEPQQLAEAARYNVDHGAQIIDINMGCPAKKVCNAWAGSALMRDEQLVARILEAVVNAVDVPVTLKIRTGWDCDHRNGPLIARIAEDSGIAALAVHGRTRDQHYTGQAEYATIGEIKAALRIPVIANGDIDSPQKAAYVLKETGVDAVMIGRSAQGRPWIFREVAHYLATGEELPPPSLAEVRDILLGHLHALHAFYGEPQGVRIARKHLGWYAKDRPENAAFRAVVNRAEDPASQIALTTEYFDRLIAGEPALPSAA
>NC_010943.1|WP_005408109.1|827243_828071_-|methyltransferase-domain-containing-protein
MTPPISSPTYLHGFSGTEQQRLMTQARLLESSIFGQIDYSGARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLATARENLARTPWCSDRYTLQQADAGELPFEARSFDAAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYITEVMNASFLLDPYSPHIWRYWMAFNDFQYDHGGDPFVGAKLGNLLLAGGFRDVHTEIKTIHLDNREPARRKTMIAFWEQLLLSAADQLLQAGSVDEETVEGMRREFRLVQNDPNAVFFYSFVQGRATVY
>NC_010943.1|WP_012479175.1|825254_827105_-|hypothetical-protein
MDLTCERMMSDSGRTPFSTHEVNLPGGLPPGQTRLLAGIIALLCILYVAFALTPSSYSLAYEYLGLAPQNPVLGSARMIRSDEWIVFTPYIQIAVNNDFGQFNAHSPYHESLRTFQALPLLDWGLLFKPYHWAFFVLPAANAYSFFFMFMAMAFLSGWALFLRQLRMPVPAAVLVSATLFFAPFVQVWWTSNAGAFALAPWAAAAWLCIGNRWVRILASAYALAVWVIAVSYPPFIISSLLAMAVLVLAFRRDALTLPRLIDAGIAGALALAVFIGYFHDIIPIVRNTVYPGQRQSAGGGVGLTSLFAHVFPNLMTYRFAPLPMFKGSNECEIAVLGSLLPLFTLVLADGARLREWVRGHRGSVLALAAGVLLIACWIFLPVPVLVGKLTGLSMVPPARALLAFGLLLNIGCAMILVHCGVRLERRRLLLLAALLMAGSVAKFLFGEGQFSRLHSAADAIPYLCLAGLAVAARRPKLSAHAATLVLATAALANLLGNGLFNPVQPAGPIFAMDRTAVLHSLQARGSATTPEGALVAPGGFGALLPGVGIPAVNHVLYLPQMEYFRRYFPLMSDEAFNFTFNRYHHITVAPEGDAPRVLQGDLVELPAKALLAHPAP
>NC_010943.1|WP_012479174.1|824247_825258_-|glycosyltransferase-family-2-protein
MSPMTTITPSASTPARIAVIIPCYKVTRHVLSVLAAIDDAVTAIYCVDDACPDGSGRLILAEANDPRIAVLFHQHNLGVGGAIKTGYRAAIADGMDILVKVDGDGQMDPALLMDFVAPIADGHADYTKGNRFWNLTHIRRMPPVRRLGNLLLSFMTKASSGYWQVFDPTNGYTAIHAKVASHLKLEAVSDRYFFETDMLFRLNTVRAVVQDVAMDAHYGDETSNLRIGRILGEFSFKHLRNTLKRIAYNYFLRDLSIASLELIAGSSLLAFGGLFGLYHWVRSAQADVATPVGTIMIAMVALISGLQFLLAFVGFDIANVPRQVLNRSIKLNRQPQ
>NC_010943.1|WP_012479173.1|823130_824189_+|metal-dependent-hydrolase
MDSLTQIVLGGAVAAAIAPPGHRRAALLAGAALGTLPDLDALWLGFTAADPVANMIEHRSFSHSLLVLPWVAALIWWLFKRFGNGRVAQSPVRWFWAIQLALVTHPVLDAFTVYGTQLWWPLRPHPTMGSSVFIIDLGYTVWLLLGCVLAWFGRARPWAGKVLGVALLLSSAYLGWGLIAKAQVDRAAQQSLAAMGLGDAPRFSVPMPFNTLLWRVVAMTPNGYVVGDRSLVADHGPMQFEGHASNVQALREAGSIPAVQQLTWFNRGFMRAQVVDGRLVLSDLRMGLEPDYTFNFAVAEQVDGQWRPITPEQVRTDYSSPAARADAGRRLAAMWQRIWHEPAASATGAAHP
>NC_010943.1|WP_012479172.1|822179_822980_+|UDP-2,3-diacylglucosamine-diphosphatase
MSVLANLSPHRRAVFVSDVHLGSRHCHATELARFLSQLRCERLYLVGDIIDLWWMAHRRANWRQSHSEVIQALHALRRAGTEIVYIPGNHDASLRQVCGLMLPAMQVRRRAIHVTADGRRLLVAHGDEYDGVTHFGGLQEKFGDWLYYRILTGNQALNAVRRRLGMRYWSLSEFLKKRSGAAERYIERFVQAGLDDVRRRGLDGIVCGHIHRAALVERDGLVYANDGDWVESLTALAEDHDGALRLLDHNGQTLVELPGARLSQAA
>NC_010943.1|WP_012479171.1|820467_822183_+|lysophospholipid-acyltransferase-family-protein
MQELEQRLQQRFPDWFHGRRGQLARPLLRSVGRWSRLDQIEAFLQRSAGLRGFGFVAAGLEFIDGQYQVDPAALAKIPATGRLLIVANHPSGALDALALLDAVGRIRRDVRIVANDLLGAIAPLQDLLLPVRILGGKAQRGSLHAVEEALAAEQCVIVFPAGEVSRLSLRGIRDGRWQRGFVRFARAAGAPVLPVRVEARNSALFYGASTLFKPAGTALLAREMFTRRGRPLRLSIGEPMQLGKGGDPGAQLLAVRRALYALGRNGAAGNAAAFAGPEPLAAPVPPSQVAAGIAAATQLGQTADGKQILLATCTADSPLLLELGRLRELTFRQVGEGTGRSRDLDDFDSRYEHIVIWDAAAQRIAGAYRIMRGAHALARHGLSGLYSASLFRYSDDAITHIAEGLELGRSFVVPDYWGSRSLDYLWQGIGAYLQCRPGIRYLFGAVSISAALPRDAREQLVAYYQRYYGGTAGLAESNRPFQYFAAPPSFGELDAGAAFDVLKANLAALGTGVPTLYRQYTDLCEPGGARFLAFGVDPDFSDSIDGLIEVDLCAIRPNKRKRYLRDAGTPA
>NC_010943.1|WP_005408103.1|818933_820145_-|methionine-adenosyltransferase
MSSYLFTSESVSEGHPDKVADQISDAVLDAILTQDQRARVACETMVKTGVAIVAGEITTSAWIDLEALTRKVITDIGYDSSDVGFDGATCGVLNLIGKQSPHIAQGVDRKKPEEMGAGDQGLMFGYATNETDSYMPAAIHLSHRLVEQQAKIRKKKNSPLSWLRPDAKSQVTLRYENGVVSAIDAVVLSTQHAPGIKQKDLIEAVREEIIKPVLPAKWLHKGTKFHINPTGKFEIGGPVGDCGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAARYVAKNVVAAGLADRCEVQVSYAIGVAEPTSISVTTFGTGKISDDKIEKLIRKHFDLRPYGIIKMLDLIHPMYQQTAAYGHFGRKPKEFSYLNGEGETVNATAFSWEKTDRAAALRADAKLK
>NC_010943.1|WP_005408115.1|833099_834398_-|nucleoside-transporter-NupC
MVEGLGRIGFGLFGLAVLIGITWLFSNNKRAVDWKLVATGITLQIAFAALVILVPGGRDVFDALGHGFVKVLSFVNEGSGFIFGSLMDTKNYGFIFAFQVLPTIIFFSALMGVMYHLNIMQAIVRVMAWAITKVMRVSGAETTSVCASVFIGQTEAPLTVRPYIARMTQSELLTMMIGGMAHIAGGVLAAYVGMLGGGDPAQQAFYAKHLLAASIMAAPATLVVAKLLIPETGTPLTRGTVKMEVEKTSSNIIDAAAAGAGDGLKLALNIGAMLLAFIALIALLNAPLTWIGEVTGLAAQIGKPTNLSTIFGYLLAPIAWVIGTPWADATTVGSLIGQKVVINEFVAYTELSQIVNGQVAGVSLSSEGRLIATYALCGFANFSSIAIQIGGIGGLAPERRHDLAKFGLRAVLGGTIATFMTATIAGVLTHFS
>NC_010943.1|WP_044571190.1|834591_835563_+|aldo/keto-reductase
MQYRRLGSTGLPISALSFGAWVTFGDQIPRDEARNLVAAAWDHGVNFFDNAEGYANGRAEQVMGDVIADLRLPRDGFCVSSKVFFGSAKDPRPTQRGLSRKHVTDACHAALKRLRVDYLDLYYCHRPDPDAPIAETVHAMDTLVRQGKILYWGTSEWSAVQIQQALDIAEARNLQGPSMEQPQYNLLHRERVEVEYAPLYAGAGLGTTIFSPLASGLLTGKYDQGIPADARLGREGMEWLQDLVLGADAGARLGQVRRFSEVARALGHAPATLAIAWCLRNPNVSSVILGASRVSQLLQNLQALDVLEQVDASGWAQVEAVFA
>NC_010943.1|WP_005412278.1|835883_836078_+|hemin-uptake-protein-HemP
MNAQPVLLRPETLTLRDRPVRVVPPEEVIDSEALLKGRREILIQHGDRFYRLRHTSNDKLILTK
>NC_010943.1|WP_012479180.1|836268_838476_+|TonB-dependent-hemoglobin/transferrin/lactoferrin-family-receptor
MALPLSAHAAATAAPDAREFDRVQVTATRTERAVSDVAATVDVIDREQMDRHLVQDIKDLVRYEPGLSVTRSATRFGLDGFRIRGLDGNRVRIQTDGIVMPTRFDIGSFASSNRNFTDLDTLKRVEIVRGPASSLYGSDALGGVVAFVTKDPADYLKGGKNSYFGLKFGYDGEWKGLLGGATAAFGGDHWSGLVNVNHHQGQETDNKGTVRSDNDTRTAANPQDRDGRSLLSKLVYAPSEDQRFRLTVEGNEDTTDTNVLSAIASVAPRPGAMAAATGMKSHDTQKRNRVSFAHEMDALDQPFADSLHWQVYAQNSETRQQTDETRTDGTRRHRVFSFDQHAYGLQAQFNKAFTTGSVEHALTYGFEGTRTEIRQKRDGYQVSKAGVVSNTVLPDTFPVRDFPISKTTELGLYAQDEMRFADGRLSLVPGVRVDRYELKPEVDSIFAEDNPTTAVAQLKKTSVSPKLGMVWRFTDEWSLFAGYARGFRSPPYNDVNIGLTNVAFRYTAVANPDLKPETSDGYELGLRFIAPAAYVSVSGYYNDYKDFIQSNVDTGRNAQGLTVFQSQNIADARIYGAEMKAGIEFGELSPALKGWALRSALAWSRGDNRTDDEPLASVDPLRGTLGLMYDTDTWGVELAGTFVQRKKRLPPPAAQTNPNAPAPFVYQPAGYGVLDLMAHWNFAPGATFNVGVFNLADKRYIEWSSITPSLITDRALSDRFSSPGRTFSASLAVSW
>NC_010943.1|WP_005408118.1|838480_839080_+|hypothetical-protein
MSRALSARRNDSIAAPNSAAWPTPAQLATLGTVLCLYHADGNELGGWRQAVRVHACQGVDSEGLRESLCFLDGRGRCVWRLYLLPDSDFLAWDRLVAALPPGPEHDSEASVGERLWRRLAGHLGGQRWRLCALRLHAADDGRTLAASLSTLSSLGAATARRIARLEGAEGELAIDDCCCADAARRPAPQIPGDLPLIRL
>NC_010943.1|WP_044569529.1|839153_840080_+|hypothetical-protein
MKLQTASAMLLLAASGVASAQPSDIARDHDSILAMQGEYTVDFAFDETVLLKPGYERAPAMRSGGSEVVIVVENTPKRIVLQHLLLDEKSGHITKHWRQDWVYEAPNRFEFSADQTWKVRSIPSAVNQGAWTQCVYEVSDAPRYCGTGTWTYTNNVPSWTSDLSWRPLPRREYTKRSDYNALAVVNRHTLTPNGWTHEQFNTKVQRNADGSQVEIAREFGFNDYVKTTEVDFTPARNYWKATAGYWAKVRQRWDGFLTQAPGVHLKTRIDGMAMIIPLFTQAEEIQSGKKVKDKQIDEVFAKYVEKAQ
>NC_010943.1|WP_012479182.1|840187_842704_-|FtsX-like-permease-family-protein
MNLLRHAWRALRREALAGDLLTVFAALVLGVAVMTAVGTLVNRVNLALTGSAAEMLGGDLGIAGRDDPPQAFADEAQRRGLAFTRIASFGSVLFNGDASQMASIKAVQAGYPLRGTLRVRSTPGGALIANAGMPPKGQAYADPRLLQGLGLKAGDDLEFGAGTLRIAGIIEAEPDAGGDLLTLSPTLLVNRADVEGTGLLGPGSRINYRLMFAGSADQVAALRQWLLPQVRGLRLLSVDDTQRGVRQAFDLAGRFLGLSALLAVLLAGVATALAANRFALRRIDQVAILRCLGARQRDILLGLALQLLMLAVPACALGIGLGMAAQEGLVQVLGSLVPQRLPLPEAMPALTGAGIGLLLLFGFGLPPLLRLRGVPPMRVLNRSFAALPPASLLAYVAALAASLLLAVQVTGDLKLALWVLGGLAALAVAAGVVGFALLQLLRGLQHRLHGHWRLGLAALTRRRMLAVMQLVGLSLSLCALLLLAVTGPGLLQQWRERLPADTPNYFLINIQPEQRDSVLAALRGLGANDASIEPMATGRLIAINGKPPLRVDRSPDQSGQPASGEAQRDDDDENRPLNFSWRSSFPPANTLMNGTFWTPDSTASEASVEIGWAKRYGVYPGDRITIAVGEQEREFTVTSVRKADWNTFRPNFFVLLNPNAVGDTPHNLLSAFHLPAGKAAGLGELVRAQPNLSLLDVDAVISQVRDVMERVAQAVQLVMVFSLLAGVLVLLAALQATAGERRYDSAVLRTLGATRRQLRGAVLVEFGALGTLAALLAVGAAAAIGVAVSQKVFELPLLPPWPGLLIGGVVGIGLSLLAGWWGTRAILHTPPALALREA
>NC_010943.1|WP_005408121.1|842700_843348_-|ATP-binding-cassette-domain-containing-protein
MQGPEGEVHILDNITLTVHEGTSVAIVGASGSGKTTLLGLLAGLDLPSRGRIALAGQDLSALDEEARAQLRAREVGFVFQSFHLLPALTAAENVALPLELAGREDRARVDEVLAQVGLAHRARHYPRQLSGGEQQRVALARAFVTRPRILFADEPTGSLDHATGQHISDLLFELNAGSGTTLVLVTHDLRLAQRCQYIHRIDDGRLLPVERGAQA
>NC_010943.1|WP_012479183.1|843423_844068_+|arylesterase
MRKTGWSRRAGAMMVLLLGFLLLPGLACAKGPAGTVLVLGDSLSAAHNIPADAGWVSLLQQRVRQQSKTPARIVNASMSGETTAGALTRLPALLAKEKPTVVVIALGGNDALRGLTPAQVQGNLGKMVQASQKAGAKVLLLGIDVPPNYGPAYRQRLAAAYRALATQYKVPLLPFLLEGVALQPGMMQADGLHPTAQAQPKVLDNVWPLLRPLL
>NC_010943.1|WP_002811889.1|844155_844869_+|response-regulator-transcription-factor
MRQTKETSGLVLVVEDNRNISEMIGEYLEGRGFEVDYAQDGLDGYRLAAENSYDVVVLDLMLPRLDGIEVCRRLRNDARKSTPVLMLTARDTLDDKLTGLGFGADDYLTKPFAIQELEARLRALIRRERRQVGSEVLKVADLVLDPVSMRATRAGTELQLSPIGLRLLTILMRESPRVVTRQEIEREIWGNGLPDSDTLRSHLYNLRKIIDKPFDRPLLHTVQSAGYRIADIAQPMA

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Crispr_ID: NC_010943_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010943_6

2370633-2370740

Orphan

Consensus_repeat	Method
CATCCACGCATGGCGTGGATCTACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010943_6

>merge|NC_010943|6|2370633-2370740|CRISPRCasFinder
CATCCACGCATGGCGTGGATCTACCACAACCCGCTTTGGTGGGTGCCGACCGTTGGTCGGCACGGATGCCTGTGCCTCTCGATCATCCACGCATGGCGTGGATCTACC

>NC_010943|6|6|2370633-2370740|CRISPRCasFinder
CATCCACGCATGGCGTGGATCTACC	ACAACCCGCTTTGGTGGGTGCCGACCGTTGGTCGGCACGGATGCCTGTGCCTCTCGAT
CATCCACGCATGGCGTGGATCTACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_010943.1\|WP_005409587.1\|2372828_2374019_-\|chemotaxis-protein	unknown	unknown	gnl\|CDD\|206779
NC_010943.1\|WP_005409575.1\|2358575_2358983_-\|flagellar-basal-body-rod-protein-FlgC	unknown	unknown	gnl\|CDD\|183634
NC_010943.1\|WP_012480135.1\|2377497_2378310_-\|APH(6)-family-putative-aminoglycoside-O-phosphotransferase	unknown	unknown	gnl\|CDD\|226100
NC_010943.1\|WP_005409592.1\|2376978_2377305_+\|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl\|CDD\|178809
NC_010943.1\|WP_005409591.1\|2376395_2376866_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_005409590.1\|2375932_2376394_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239647
NC_010943.1\|WP_012480128.1\|2360731_2361388_+\|flagellar-basal-body-P-ring-formation-protein-FlgA	unknown	unknown	gnl\|CDD\|183625
NC_010943.1\|WP_005409580.1\|2361765_2362104_+\|flagellar-protein-FlgN	unknown	unknown	unknown
NC_010943.1\|WP_005409576.1\|2358986_2359382_-\|flagellar-basal-body-rod-protein-FlgB	unknown	unknown	gnl\|CDD\|183628
NC_010943.1\|WP_005409582.1\|2363822_2365595_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NC_010943.1\|WP_012480133.1\|2374182_2374797_-\|high-frequency-lysogenization-protein-HflD	unknown	unknown	gnl\|CDD\|234690
NC_010943.1\|WP_005409579.1\|2361463_2361769_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	unknown	unknown	gnl\|CDD\|274802
NC_010943.1\|WP_005407612.1\|2371588_2372503_+\|IS110-like-element-ISStma6-family-transposase	unknown	unknown	gnl\|CDD\|226077
NC_010943.1\|WP_032966708.1\|2372514_2372730_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012480129.1\|2365599_2367702_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|226951
NC_010943.1\|WP_005409581.1\|2362195_2363413_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340419
NC_010943.1\|WP_012480130.1\|2367833_2370593_+\|phosphodiesterase	unknown	unknown	gnl\|CDD\|236645
NC_010943.1\|WP_012480136.1\|2378448_2380734_+\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA	unknown	unknown	gnl\|CDD\|236828
NC_010943.1\|WP_012480134.1\|2374793_2375936_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_010943.1\|WP_005409577.1\|2359519_2360464_-\|chemotaxis-protein-CheV	unknown	unknown	gnl\|CDD\|381151

Protein	Function_ID	Function_description	E-value
NC_010943.1\|WP_005409587.1\|2372828_2374019_-\|chemotaxis-protein	gnl\|CDD\|206779	cd11386, MCP_signal, Methyl-accepting chemotaxis protein (MCP), signaling domain. Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.	7.72638e-31
NC_010943.1\|WP_005409575.1\|2358575_2358983_-\|flagellar-basal-body-rod-protein-FlgC	gnl\|CDD\|183634	PRK12629, flgC, flagellar basal body rod protein FlgC; Provisional.	1.2905e-80
NC_010943.1\|WP_012480135.1\|2377497_2378310_-\|APH(6)-family-putative-aminoglycoside-O-phosphotransferase	gnl\|CDD\|226100	COG3570, StrB, Streptomycin 6-kinase [Defense mechanisms].	1.02413e-74
NC_010943.1\|WP_005409592.1\|2376978_2377305_+\|ATP-dependent-Clp-protease-adapter-ClpS	gnl\|CDD\|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	4.26539e-44
NC_010943.1\|WP_012480128.1\|2360731_2361388_+\|flagellar-basal-body-P-ring-formation-protein-FlgA	gnl\|CDD\|183625	PRK12617, flgA, flagellar basal body P-ring formation protein FlgA.	1.54937e-107
NC_010943.1\|WP_005409576.1\|2358986_2359382_-\|flagellar-basal-body-rod-protein-FlgB	gnl\|CDD\|183628	PRK12620, flgB, flagellar basal body rod protein FlgB; Provisional.	8.61259e-79
NC_010943.1\|WP_005409582.1\|2363822_2365595_-\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	5.55568e-97
NC_010943.1\|WP_012480133.1\|2374182_2374797_-\|high-frequency-lysogenization-protein-HflD	gnl\|CDD\|234690	PRK00218, PRK00218, lysogenization regulator HflD.	6.36392e-86
NC_010943.1\|WP_005409579.1\|2361463_2361769_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	gnl\|CDD\|274802	TIGR03824, FlgM_jcvi, flagellar biosynthesis anti-sigma factor FlgM. FlgM interacts with and inhibits the alternative sigma factor sigma(28) FliA. The C-terminus of FlgM contains the sigma(28)-binding domain.	1.67856e-14
NC_010943.1\|WP_005407612.1\|2371588_2372503_+\|IS110-like-element-ISStma6-family-transposase	gnl\|CDD\|226077	COG3547, COG3547, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.09325e-23
NC_010943.1\|WP_005409590.1\|2375932_2376394_-\|NUDIX-hydrolase	gnl\|CDD\|239647	cd03675, Nudix_Hydrolase_2, Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.7154e-70
NC_010943.1\|WP_012480129.1\|2365599_2367702_-\|PAS-domain-S-box-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	4.33028e-43
NC_010943.1\|WP_005409581.1\|2362195_2363413_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|340419	cd16943, HATPase_AtoS-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS. This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.	1.6216e-52
NC_010943.1\|WP_012480130.1\|2367833_2370593_+\|phosphodiesterase	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	1.20505e-105
NC_010943.1\|WP_012480136.1\|2378448_2380734_+\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA	gnl\|CDD\|236828	PRK11034, clpA, ATP-dependent Clp protease ATP-binding subunit; Provisional.	0
NC_010943.1\|WP_012480134.1\|2374793_2375936_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_010943.1\|WP_005409577.1\|2359519_2360464_-\|chemotaxis-protein-CheV	gnl\|CDD\|381151	cd19924, REC_CheV-like, phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins. This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.16931e-37

>NC_010943.1|WP_012480130.1|2367833_2370593_+|phosphodiesterase
MDQGIIASLLQHPLASALVIVDRTGRPLAANPAAREHGLPATVAAYAPMLEDLRLMAADGGIVACTLPGGPHGHYDGHLRAVHDGAGNLLAFTLSIPEPVPLGGGGRWELALDSAGHSLWDWDIPSDRVVRTPAVGDETATEMLARVHGEDIAQVRAALDEHLRGLSEQYSAQFRFRQADGQWRWVLDRGRVVARTADGQPLRMVGTHTDIEQQKQLEGLLQEQQLHLSEAQRIASMGSWSFDPNSGDFWWSPELRSMLALEQGAVPGQRRWLKQLHPRSRGALRAAWGRLWRDGRAANLELELTRGNEPSQHLRLWMQPLLDMDGQPKRLLGQVQNITEQHQTDALIRWRTELLNRVSALGRIGGCEIEVKTRHMQWTEECYRIHGLRKEPITLDQALALYTEDSRNAFEAALARIANGGLPEQLDLCFYRQSGLRVWVQVLIELDRRDGLPPRFVVLFRDITREREANERIELLAHYDLLTGLPNRVLLGEQTAEAIEEARDRGTSLAMLFIDLDGFKTINDSFGHATGDALLKAAATRLHQNLRNNDLFGRFSGDEFIVVLRDLAEPEDAGHVARKLIASLAEPLRRGETTLKVGASVGIAMLGDAQTDFDSLLRAADAAMYAAKEAGRNTYQYYSQDALARIQRKLELEHALHGAIEREEFSLAYQPLLHAHHGEPPAIEALLRWHRPGIGYCSPAEFIPIAEKCGEIVRIGDWVLNEACRQATAWDRAGLRFDRIAVNVSAVQLRDRGFAERVIEICHAHGWPPQRLELELTESALIRDTDILRHCFDVLERHGVPLAVDDFGTGFSNLNYLNRFPVGRLKIDRSFVQGMLHDSGTAEVTQAIVHLGHALGMKVVAEGVETHQEEDMLRRQGCDEIQGYLYSRPLSPRDLAQWLRQPQPVSLRTDASGEVMLVR
>NC_010943.1|WP_012480129.1|2365599_2367702_-|PAS-domain-S-box-protein
MPAEPTGTAFVPDPRMAQALSRDRRRVVLSYLVMALAWMIASDSAVQALVPDPQQAAMWQSVKGSFFALASAGLLYLLLRPLAEHVLHTHARQQASELRLRQMFEGNPGPILVYDLDTLAILDANPAACTAFGWERDELLEQTIDALWPPGQDQALQTKLEAIREAPEELCILRTQLQLRDGSLRQMELRSNAISYDGHNARLLIAIDRTAEDLAQLRRDQALARVEEAHELARIGAWELDPSTGMGRYSNQVYRLLGRRPPEARRWHRFDELLVPADPATATQTEQLLADLCSGDPVQVDVLLPLLSMDGRALMVHLRAASGVDESGRSRVLGTLQDVTEREQSRRLLREREEQFRELVRVLPDGVVILSEEHVLYTNAWAASLFGYGSHTLLGEPLSALVAAGDLARVRGQLRAGQPHLGPGHSSVVAMQRADGRSFHAGLAVGEVRYGGRDCKLLIVRDLSDSERTRSALETSNRELQAMAGRLFSLQEDERRAISRDLHDDIGQAITAIKLSAHAAQDEHDPQRRAEDLAQIVSLADTTVAKLRDISTLLRPPQLDALGLEAALSWQARVLFRSSQVELLAEIEPLPHRPDNSIEQACFRIAQESLTNVLRHARASQVHLQLRDIGKRSLHLQIRDDGEGFDPDGPRGLGLIVMRERAQSVGGHVRIESAHGEGTLIDVHLPYQAASMAAVESPEY
>NC_010943.1|WP_005409582.1|2363822_2365595_-|EAL-domain-containing-protein
MWNPNQPPVSIDDAPDRLGAGNPELQAMVAEAASGGTALMLMHVDIDHFASVNENMSAEVGDQALVLVAQRLQSYLRGRGKLWRHGSDEFLIAVPRNADVPLPEDFAEEIRQQMELPLSVLPYTLFMTGKLGVSLCPEHASNASRLLDHAEDALYQAAREGGNAVRIHAVDTPPSAHSESIIARQIVDAIPNGELKLRYQPLVSARDGHVVGMEALLRWQSPTLGMLVPERFMRTAERLGIIVQIGTWVLEGALKQARLWRDQGFDDFTIAVNVSTLQLLRPNFFAEVMGLIQAAGVPAQMLTLEINESALTNNVNFVHETLANLRNEGISLSLDNFGTGDSSLSALVRYPVDKLKIDRSFIKSAPAGNREAAIARAIIAMGHQLGMTVIANGVESQAQLGFLRRNDCDVFQGYLFGEPMSADAAGMTLRRRYLRPEAFAETRPDRTLLLLDDEENVLRSLVRLFRRDGYRILAAGNVRDAFDLLAINDVQVILSDQRMSDMSGTEFLGRVKMLYPDTIRLVLSGYTDLNTVTDAINRGAIYRFLTKPWNDDELRKHIHQAFRTYEEQRRSNAGPAPAESGDGGEDRPLR
>NC_010943.1|WP_005409581.1|2362195_2363413_+|two-component-sensor-histidine-kinase
MSAANALVTAPLPPQPVLQALLERLREGLLLFTEDGQVALANPAAQNLLAGGEDGALPPQRLRELLPPDALEQARQHGHWNGSLPLGEGVVIAHLYHHGPVGQGHFLALFRHIEGQEDYERELQQRHAELRQAYLRLNGTQEKLLQSEKMASIGQLAAGVAHEINNPIGYVHSNLGSLQEYLRSLFTVIEAYERALRAPDPKALIPEIDDIRDRLDIDFISRDLPQLMAESREGIERVTRIVRDLKDFSYSGRDESWKLVDLHAGLESTINIIWNELKYKVTLVREFGQLPLVECLPSELNQVYMNLLLNAGHAIAERGTITVRTGVDGDQVWVEFEDTGGGISPELRQRIFDPFFTTKPVGSGTGLGLSISYSIINKHHGRIDLDSTPGVGSRFRVVLPVKQPR
>NC_010943.1|WP_005409580.1|2361765_2362104_+|flagellar-protein-FlgN
MTAAMSEPLQRLAQALDVERQALVEHDVHALIRATGAKLEALRALEGAPPVGQGEQLQELAERNRANGVLLSRRRREVNWALRQLGRTEDASAYDAKGQSHTVTARRPLAVA
>NC_010943.1|WP_005409579.1|2361463_2361769_+|flagellar-biosynthesis-anti-sigma-factor-FlgM
MSQKIDGNLQVPQALRSVTTPANKPGVSTDAAARPVEAADSLRLTGEATNLQAIERELTTAPAIDAQRVAAVRESLQNGTYKINPDAIASRMLDLDQQLHG
>NC_010943.1|WP_012480128.1|2360731_2361388_+|flagellar-basal-body-P-ring-formation-protein-FlgA
MRRVTSLLAIALALASPWATAADWQPVASIRTAALSTLPAGSEGEAQVADALRLPKCGGALQVQPTANTTVEVSCPDAGGWRLFVPVKVRRNQTVLVLNRGIGTGETLTAADITTAQRDAARIAGAVLADPNAAIGRIARRPLQAGALLSNNDLVVQRLIKRGDNVALVSRRGSVEVRIAGRAMGDAGENERVSVENLSSRRIVQGTVDAAGDVIVAR
>NC_010943.1|WP_005409577.1|2359519_2360464_-|chemotaxis-protein-CheV
MSHDLLNRIDQRTRLAGHNRLALLLFRLGGRQLFGVNVFKVQEVLRRPELFQVPGLPSQFSGVADVRGRSVPVLDLGLAIGHPEREPEADTSPGYLVVTEFNRSIQGFLVSGVERIVNIAVEDIHPPPELGAESSYLTAVTRFQGELIQVIDVESVLADIAQVRGEAVLDPAMAMPSDGPQLQVLVVDDSRVARQQIRSVLDQLGVGATLLSDGKQALDHLLQIHASGENPAERYAMVISDIEMPAMDGYTLTTEIRRHPGLAGLYVLLHTSLSGVFNNAMVERVGANAFVAKYSPHELADFVLDRLRKVALAA
>NC_010943.1|WP_005409576.1|2358986_2359382_-|flagellar-basal-body-rod-protein-FlgB
MRNLITDYLGVHAQAMPLREQRMKLIASNLGNADTPGYKAQDLDFDAALRHAQGQDANGLMATTHEQHYEISSGLNPFQIAREGVQPSLDGNTVDPDAERAAYGRAALEYRASLSFVESKVRSMLTAITGQ
>NC_010943.1|WP_005409575.1|2358575_2358983_-|flagellar-basal-body-rod-protein-FlgC
MSNLPIFDIAGSALQAQSVRMSTIASNLSNADTVAGSADAVYKPLEPIFQAVTSKNDPNITSVKVKEITQSDAAPIKRYEPGHPLADGDGYIYQPDVDPVAQMVNLISTSRNYQAGVEMLTTAKELALATLTMGR
>NC_010943.1|WP_005407612.1|2371588_2372503_+|IS110-like-element-ISStma6-family-transposase
MFGIGIDVSKATLDVAVHGEQFRQFSNDKRGFVRLIRWLKTWPIKQVVLEASGGYERAALDVLHAAGLPMVRINPARARRFAQGTGRAAKTDRLDATVLAQMAHLLPLTRYVPPAPWQQRLAEFAQCRRQLVQMRVSEMQRLRRLVDPDLIAMKQRHIAQLSDDLKQLDKAIAEQLEGQPGWKNIGALKGVGPILISTLACELPELGSLGSKAIASLVGLAPMNRESGTWQGQRRISGGRAVVREALYMAALTAIRYEPRLRAFYAGLKAKGKASKVALVAVMRKMLVILNARKRDAEVALGCP
>NC_010943.1|WP_032966708.1|2372514_2372730_-|hypothetical-protein
MTLIRALPSLTDTERPRNASVREQLQQLEDVAREEIRELQQLADARPAPSRADEALLGLAWDLGLDGEALK
>NC_010943.1|WP_005409587.1|2372828_2374019_-|chemotaxis-protein
MYSRIFIRLAAPLALTLLLPFAIGFEWPAALRWAILTTMTLSWLGFAWWTTRAQAHRSPEHARVLREQDQLLTELRNFVGNEIEGSRGEVERARDLIRQAVSSLGGSFDAMNRKSRQQSQALSRIVDRAGDEGNAGLDVARFAQHASHRMEQLVEALEQVSGQSSTTVQHIDQMAQHLDGIFALLEDVKSIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRNLSERSTTFNEQIRKLAHSSKDAIAKVRETVSHMASRDMDRSREARQEAAAMLDNVAQINASLGDGMREVSECARSIDGSVAEAVRALQFEDIATQALGGVHTHLDRLTAINREAVALQELLHRNGGVFDEEIATALQRTGSRLRELRSEWERPPHKPVAQQSMGAGTVELF
>NC_010943.1|WP_012480133.1|2374182_2374797_-|high-frequency-lysogenization-protein-HflD
MSFTVDDRVLALAGIAQALQQVRRIADTGHSDAAAVRTAVDSVFRVDASSPQEVFGDRHALKSGLRLLHNYFRSQGQDPILPKLALSVLQLERRFVQDGATVNKVASGIERAQRQANELGDSGHPDVLANLGGLYADTISHLKPRVMVQGNPHYLGQAGVVAEIRALLLAAVRAAVLWRQLGGSYWDFLFGRKAMIEAVDRQLA
>NC_010943.1|WP_012480134.1|2374793_2375936_-|tRNA-2-thiouridine(34)-synthase-MnmA
MSTPRVMVGVSGGVDSSVAAWRLVQQGEAVAGLFMQNWADDGSGDCRAEDDRRDAVAVCGLLGIPFHFRDFSSEYWQGVFEHFLAEYAAGRTPNPDVLCNREVKFKHFLDAARELGAERIATGHYARVTQRGHQWLLLRGADRSKDQSYFLHQLGQEQLAATLFPIGDLEKTDLRRIARDVSLPTHAKKDSTGICFIGERDFREFLGRYLPAKPGQILDPADGSVIAEHPGVFYFTLGQREGLNIGGVRGRPAAPWYVVGKDVASNVLYVDQDRDSKWMLSERLRSETAHWIAGSPPARRFECTAQTRYRQPDEPCTVQVLDDGSVLVTFARPQRAVTPGQSLVLYDGDVCLGGAVIAATDAPLEQRLRTTPSPFEVIAA
>NC_010943.1|WP_005409590.1|2375932_2376394_-|NUDIX-hydrolase
MNATPDPRWAPHATVATVVVDGGRVLLVEETIDGRQVLNQPAGHLEPGESLAEAALRETREETGWTVQLTHFIGCYQWTAGDGTAFLRFCYAARPVSHDPAQPLDTGIDRALWLTPAELQAAGERQRSPLVWQVVADYLGGQRHPLSLVREVA
>NC_010943.1|WP_005409591.1|2376395_2376866_-|hypothetical-protein
MKRTLLPALLIALAATGSAAAADADKAVARHLDKLGYTYEVDEDGDYRMVFDVEGDRTQMVYVRSSVEDFGTHNIREIWSPAYNAKTKQFPVAVANRLLEDSQDAKMGGWVKQDTTAMFVVKIDADATADQLSDAIDAAIRTADAMELELTKKDEF
>NC_010943.1|WP_005409592.1|2376978_2377305_+|ATP-dependent-Clp-protease-adapter-ClpS
MPHESSPDSQHEHGVAVEAARPEVAPPPFYQVMLLNDDYTPMDFVVDVLQQFFSMDLDKATQVMLHVHTRGRGVCGVFTREVAETKVAQVNEYSRMNQHPLLCTMEKA
>NC_010943.1|WP_012480135.1|2377497_2378310_-|APH(6)-family-putative-aminoglycoside-O-phosphotransferase
MSEPYLSRWRLRRDGPALRTPHARLWPVLTAAGEPAMLKISSETEEQNSHRLLRWWNGDGAARLLAHEGPAILIERARGDSLRQRSIEGDDDACTAILCQVLQRLHRPRSAPPAELVCLRTWFADLLQPRAVLPPLLEQCRSLAEGLLHDEQEIRPLHGDLHHDNVLDFGPRGWLAIDPKRLLGDRAFDYTTMFSNPDLCGPGIHVATRPERFAIRLEQVCALSELERTRLLRWIAASTALSAVWFRDDGDPADIDETVARMALEALAEK
>NC_010943.1|WP_012480136.1|2378448_2380734_+|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA
MFSKDLEHTIGQCYKRAREARHEFMTVEHLLLALLDNPSAQAVLKACGADADRLRQELEQAIEASVSRLAEDDGRDTQPTLGFQRVLQRAVYHVQSSGKKEVTGANVLVAIFGEKDSHAVYYLNQQDVTRLDVVNYLSHGIAKLGDEGEQSSSSPEGEGRMEGGEGEPKGDALTEFASNLNDQARAGRIDPLVGRADEIERTIQVLCRRRKNNPLYVGEAGVGKTAIAEGLARRIIEGSVPDVLADAVIYSLDLGALVAGTKYRGDFEKRLKSVLTALKKVPNAVLFIDEIHTIIGAGSASGGTMDASNLIKPALASGELRCIGSTTFQEYRGIFEKDRALARRFQKIDIVEPTVGETYEILQGLKSKYELHHGVTYSDEALQAAVDLSVKHIGDRLLPDKAIDVIDEAGARQRLLPEEQRKELIDVEEVEAIVAKMARIPAKQVSATDKDVLQHLERNLKMVIFGQDPAIETLSSAIKLARSGLGNPEKPIGNFLFAGPTGVGKTEVTKQLALQLGIELVRFDMSEYMEPHSISRLIGAPPGYVGFDQGGLLTEKIVKTPHCVLLLDEIEKAHPDIFNILLQVMDRGVLTDTNGREANFKNVVLVMTTNAGAAQASRRSIGFTKQDHATDAMETIRRSFTPEFRNRLDAVVQFQALGFEHILRVVDKFLIELEMLLQDKHVSLSATPTARDWLAHHGFDPLMGARPMARVIQDKIKRPLADELLFGKLVNGGKVSIDVRDDELVVETQAEPERLLPVTVE

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Crispr_ID: NC_010943_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010943_7

2755979-2756085

Orphan

Consensus_repeat	Method
CATCCACGCATGGCGTGGATCTACTGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010943_7

>merge|NC_010943|7|2755979-2756085|CRISPRCasFinder
CATCCACGCATGGCGTGGATCTACTGCCAAGCCCGCTCTGGTGGGTGCCGACCTTGGTCGGCACTGAAGCTGGCCCAGCCATCCACGCATTGCGTGGATCTACTGCC

>NC_010943|7|7|2755979-2756085|CRISPRCasFinder
CATCCACGCATGGCGTGGATCTACTGCC	AAGCCCGCTCTGGTGGGTGCCGACCTTGGTCGGCACTGAAGCTGGCCCAGC
CATCCACGCATTGCGTGGATCTACTGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_010943.1\|WP_012480443.1\|2757749_2770133_-\|filamentous-haemagglutinin-family-protein	unknown	unknown	gnl\|CDD\|372178
NC_010943.1\|WP_012480448.1\|2776944_2777472_-\|type-II-secretion-system-protein-M	unknown	unknown	gnl\|CDD\|377391
NC_010943.1\|WP_012480446.1\|2773139_2774573_-\|type-II-secretion-system-ATPase-GspE	unknown	unknown	gnl\|CDD\|131585
NC_010943.1\|WP_024956499.1\|2753512_2753848_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012480444.1\|2770332_2771508_-\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270283
NC_010943.1\|WP_012480447.1\|2774569_2776948_-\|type-II-secretion-system-secretin-GspD	unknown	unknown	gnl\|CDD\|274175
NC_010943.1\|WP_012480445.1\|2771932_2773132_-\|type-II-secretion-system-inner-membrane-protein-GspF	unknown	unknown	gnl\|CDD\|273980
NC_010943.1\|WP_012480438.1\|2753978_2754440_-\|general-secretion-pathway-protein	unknown	unknown	unknown
NC_010943.1\|WP_044570317.1\|2751694_2753311_-\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	unknown	unknown	gnl\|CDD\|225387
NC_010943.1\|WP_005409873.1\|2748742_2749408_-\|TonB-family-protein	unknown	unknown	gnl\|CDD\|223880
NC_010943.1\|WP_005409889.1\|2778628_2779534_-\|type-II-secretion-system-minor-pseudopilin-GspK	unknown	unknown	gnl\|CDD\|377165
NC_010943.1\|WP_005409890.1\|2779543_2779981_-\|type-II-secretion-system-major-pseudopilin-GspG	unknown	unknown	gnl\|CDD\|130771
NC_010943.1\|WP_012480441.1\|2755345_2755960_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|227132
NC_010943.1\|WP_012480439.1\|2754543_2754990_+\|type-II-secretion-system-minor-pseudopilin-GspH	unknown	unknown	gnl\|CDD\|130769
NC_010943.1\|WP_012480449.1\|2777468_2778632_-\|general-secretion-pathway-protein-GspL	unknown	unknown	gnl\|CDD\|273768
NC_010943.1\|WP_005409874.1\|2749447_2749861_-\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|223917
NC_010943.1\|WP_044570314.1\|2746954_2748700_-\|putative-porin	unknown	unknown	gnl\|CDD\|374891
NC_010943.1\|WP_012480442.1\|2756302_2757217_+\|IS110-like-element-ISStma6-family-transposase	unknown	unknown	gnl\|CDD\|226077
NC_010943.1\|WP_012480435.1\|2749871_2751656_-\|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl\|CDD\|227622
NC_010943.1\|WP_171956704.1\|2754998_2755349_+\|type-II-secretion-system-minor-pseudopilin-GspI	unknown	unknown	gnl\|CDD\|273767

Protein	Function_ID	Function_description	E-value
NC_010943.1\|WP_012480443.1\|2757749_2770133_-\|filamentous-haemagglutinin-family-protein	gnl\|CDD\|372178	pfam12545, DUF3739, Filamentous haemagglutinin family outer membrane protein. This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with pfam05860.	4.74873e-44
NC_010943.1\|WP_012480448.1\|2776944_2777472_-\|type-II-secretion-system-protein-M	gnl\|CDD\|377391	pfam04612, T2SSM, Type II secretion system (T2SS), protein M. This family of membrane proteins consists of Type II secretion system protein M sequences from several Gram-negative (diderm) bacteria. The precise function of these proteins is unknown, though in Vibrio cholerae, the T2SM (EpsM) protein interacts with the T2SL (EpsL) protein, and also forms homodimers.	8.95298e-13
NC_010943.1\|WP_012480446.1\|2773139_2774573_-\|type-II-secretion-system-ATPase-GspE	gnl\|CDD\|131585	TIGR02533, Type_II_secretion_system_protein_E, type II secretion system protein E. This family describes GspE, the E protein of the type II secretion system, also called the main terminal branch of the general secretion pathway. This model separates GspE from the PilB protein of type IV pilin biosynthesis. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0
NC_010943.1\|WP_012480435.1\|2749871_2751656_-\|MotA/TolQ/ExbB-proton-channel-family-protein	gnl\|CDD\|227622	COG5306, COG5306, Uncharacterized conserved protein [Function unknown].	1.38938e-40
NC_010943.1\|WP_012480444.1\|2770332_2771508_-\|substrate-binding-domain-containing-protein	gnl\|CDD\|270283	cd13565, PBP2_PstS, Substrate binding domain of ABC-type phosphate transporter, a member of the type 2 periplasmic-binding fold superfamily. This subfamily contians phosphate binding domain found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.84556e-25
NC_010943.1\|WP_012480447.1\|2774569_2776948_-\|type-II-secretion-system-secretin-GspD	gnl\|CDD\|274175	TIGR02517, Putative_type_II_secretion_system_protein_D, type II secretion system protein D. In Gram-negative bacteria, proteins that have first crossed the inner member by Sec-dependent protein transport can be exported across the outer membrane by type II secretion, also called the main terminal branch of the general secretion pathway. Members of this family are general secretion pathway protein D. In Yersinia enterocolitica, a second member of this family is part of a novel second type II secretion system specifically associated with virulence (See ). This family is closely homologous to the type IV pilus outer membrane secretin PilQ (TIGR02515) and to the type III secretion system pore YscC/HrcC (TIGR02516). [Protein fate, Protein and peptide secretion and trafficking].	0
NC_010943.1\|WP_012480445.1\|2771932_2773132_-\|type-II-secretion-system-inner-membrane-protein-GspF	gnl\|CDD\|273980	TIGR02120, Putative_general_secretion_pathway_protein_F, type II secretion system protein F. This membrane protein is a component of the terminal branch complex of the general secretion pathway (GSP), also known as the"Type II" secretion pathway. The GSP transports proteins (generally virulence-associated cell wall hydrolases) across the outer membrase of the bacterial cell. Transport across the inner membrane is often, but not exclusively handled by the Sec system. This model was constructed from the broader subfamily model, pfam00482 which includes components of pilin complexes (PilC) as well as other related genes. GspF is nearly always gene clustered with other GSP subunits. Some genes from Xylella and Xanthomonas strains score below the trusted cutoff due to excessive divergence from the family such that a sequence from Deinococcus which does not appear to be GspF scores higher. [Protein fate, Protein and peptide secretion and trafficking].	3.42119e-161
NC_010943.1\|WP_005409889.1\|2778628_2779534_-\|type-II-secretion-system-minor-pseudopilin-GspK	gnl\|CDD\|377165	pfam03934, T2SSK, Type II secretion system (T2SS), protein K. Members of this family are involved in the Type II protein secretion system. The T2SK family includes proteins such as ExeK, PulK, OutX and XcpX.	5.29272e-33
NC_010943.1\|WP_044570317.1\|2751694_2753311_-\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	gnl\|CDD\|225387	COG2831, FhaC, Hemolysin activation/secretion protein [Intracellular trafficking and secretion].	4.81637e-78
NC_010943.1\|WP_005409873.1\|2748742_2749408_-\|TonB-family-protein	gnl\|CDD\|223880	COG0810, TonB, Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane].	2.00552e-08
NC_010943.1\|WP_005409890.1\|2779543_2779981_-\|type-II-secretion-system-major-pseudopilin-GspG	gnl\|CDD\|130771	TIGR01710, Type_II_secretion_system_protein_G, type II secretion system protein G. This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	4.00338e-57
NC_010943.1\|WP_012480441.1\|2755345_2755960_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|227132	COG4795, PulJ, Type II secretory pathway, component PulJ [Intracellular trafficking and secretion].	9.62448e-16
NC_010943.1\|WP_012480439.1\|2754543_2754990_+\|type-II-secretion-system-minor-pseudopilin-GspH	gnl\|CDD\|130769	TIGR01708, Type_II_secretion_system_protein_H, type II secretion system protein H. This model represents GspH, protein H of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	2.68049e-19
NC_010943.1\|WP_012480449.1\|2777468_2778632_-\|general-secretion-pathway-protein-GspL	gnl\|CDD\|273768	TIGR01709, Type_II_secretion_system_protein_L, type II secretion system protein L. This model represents GspL, protein L of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking].	3.91448e-20
NC_010943.1\|WP_005409874.1\|2749447_2749861_-\|biopolymer-transporter-ExbD	gnl\|CDD\|223917	COG0848, ExbD, Biopolymer transport protein [Intracellular trafficking and secretion].	8.7853e-35
NC_010943.1\|WP_044570314.1\|2746954_2748700_-\|putative-porin	gnl\|CDD\|374891	pfam16930, Porin_5, Putative porin.	0
NC_010943.1\|WP_012480442.1\|2756302_2757217_+\|IS110-like-element-ISStma6-family-transposase	gnl\|CDD\|226077	COG3547, COG3547, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.24479e-23
NC_010943.1\|WP_171956704.1\|2754998_2755349_+\|type-II-secretion-system-minor-pseudopilin-GspI	gnl\|CDD\|273767	TIGR01707, Type_II_secretion_system_protein_I, type II secretion system protein I. This model represents GspI, one of two proteins highly conserved at their N-termini and described by pfam02501 but easily separable phylogenetically. The other is GspJ. Both GspI and GspJ are proteins of the type II secretion pathway, or main terminal branch of the general secretion pathway. This pathway carries proteins across the outer membrane. Note that proteins of type II secretion are cryptic in E. coli K-12 - present but not yet demonstrated to act on any target.	2.95348e-16

>NC_010943.1|WP_012480441.1|2755345_2755960_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MKRTAAGFTLIEVMIAITIMGVLALICWRALDSVASSDQRLRRADAETTTALRVLQQFQRDIEMRADDALMNGAVRPADQPQRLLPPSLVSERHPDGSFALEITRSLGSDGLRWQRVRWWRQGSTLWRASGAATDRYPLPAPDPSKGIAVAQDVQRFEVRAWQPGAGWALLPSKGEVLPATGLELRLGLRDGRGPLSYRRVLEL
>NC_010943.1|WP_171956704.1|2754998_2755349_+|type-II-secretion-system-minor-pseudopilin-GspI
MRGFTLIEVLIALAIVSIALAAVMRSVAVATDDQSRLRDRRLALMCAQDRWQELRLAGQPPQNARQRCVQGRSSFLVLQHIGTGSDGQPQLELSVVAEDAPRQSLARMQLPWTAAQ
>NC_010943.1|WP_012480439.1|2754543_2754990_+|type-II-secretion-system-minor-pseudopilin-GspH
MQHVPRGFTLLELMVVLVIIGICTAGIGLGLGSLLDPARQLRQEAERLAQRLQVARDQARIDGRPLRWQADAAGYRFSRREGTRWVDVQRDDLLRPQQWQPAGIAVQPTTPIELSPEWIGVAWELRLSLQGRQLRLRDDGSGQLQVVQ
>NC_010943.1|WP_012480438.1|2753978_2754440_-|general-secretion-pathway-protein
MVRNMDGRRWDRNRILTLLAATLLLAVVAYWGVTLSAVAPTAAASETHAEAPARPLFDAVASLPLVRLLSPGAVQTEVVVLGVMAGDHAPLALLSVDGRPAEAYAPGQRLGPCTVLASISASAVELNQAGQSRSLPVPELPPVPSDGIVLAAP
>NC_010943.1|WP_024956499.1|2753512_2753848_+|hypothetical-protein
MRESLMVELRAALILALLLVLAPVRADEAKKQEDAAPCIEVQVNGERIPAWDCLQRKLAPASKAAKSPALPEAERLMRQPGNQLMQYNLEGTRQRMGDAFGRSVVPQRPAR
>NC_010943.1|WP_044570317.1|2751694_2753311_-|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein
MTPVPCRAVRLPLRLHPLVLALAALPLPLFAQEAAPAPSVNINEYIVRGNTVLDPRQIERAVEPFLGPGKTLADVEKARDAVNALYQQAGYQSVYVELPEQQVSGGVVLLKVQQTPIGQLRVVGTKHESPERIRERVPALAEGKVPDFDQAQKELTALNEGGRRQVMPLVREGQVPGTMDVDLQVEEKSPWRASASLNNDHSADTEKLRLSASLAYDNLWKRGHSANIGVYLAPEDAKQAKVFSASYTMPFEGTPWSLEASGYKSDSRVLNAGGQVGTGTGTNVIGNGHSIGLKLNYRLAGSSQWWRQLSLGVDFKDTEEDTQMGKESLKTPLKYAPITLGFVGVRQGEKDQLSINTQLVAGTRRLFGYGSDAIGFGQKRYWADPSFVAFKADVANTHTFSSDWQWYARGSLQVTDAPLVSAEQFAAGGMYTVRGYLSAEAIGDYGGLASLEWRTPAWSLWSGTDLRVYSFADAAYLRLRQPLPEQRDKYNLASVGLGAQLRLGEHLQLRLDYAWPYADGPVTRKDDPRLHFNISTSY
>NC_010943.1|WP_012480435.1|2749871_2751656_-|MotA/TolQ/ExbB-proton-channel-family-protein
MDRLLSRVLLLLAALVALPAAAADANWWQAEWKYRKPITIDAGPQGAGLAGDPGRTPLLLRLHTGNFGFDGTQDAGNDLRFVSGDGRTVLAHQIEQFDPKLGLALVWVDVPAVSAAAPQMIWMYYGNEKAPASGNGQQVFDPDYTLVYHFAEANAPARDTTAYGNNAGAVVPPSEGSVIGRGVQLGAAPLPLPASASLAQEAGAPLTVSAWIKPGSNNAAQAIYARRDGASELVLGIENRVPFVQLNGQRSTPAQPVPEGQWAHVALTAEKGALQLYLNGRVVAQLSGELPALTTAPVVGADAPGAVQPLANFEGALDELRISRVARPVALLLADATAQGADSRLISYGADEQSAGQSHFAFILKAMPFDAWVVVAILGLMMLLSWAIMIAKGRHFGRTSKANAVFTESFGKLSGVPLRTLSDMDRQGKAPTAMHDGSLWRIYQVAIDEMQQRHQRDGNSGYLSGATIAAIRASMDAVMVREQEAMARRMNWLSTTIEGAPYVGLFGTVIGIMLVFVVAAMAGAVDINSVAPGMAAALLCTAAGLGVAIPALFGYNYLGARAEAIGADMAVFIDEFAARLAEEQDGRGPAAVQG
>NC_010943.1|WP_005409874.1|2749447_2749861_-|biopolymer-transporter-ExbD
MGQKAKFGIKKREKGINVTPFVDVLLVVLVIFILTSNASIPGIEVNLPKASNSVALEKPKTKAITIDPSGQVFLDAYPVTMAELEDRLRTERATTPDFPVIVRGDAQVQYARVVEVLDLLRRLELAQVGLVTGKAQG
>NC_010943.1|WP_005409873.1|2748742_2749408_-|TonB-family-protein
MRGRQLLVTVALVLAALLVLGIAVWWMLFRDTASTRRPVVQPPMLALPPPPPPPPPPPEKPPEPETPPEETIPEPEPLDQPTPAEEPTPTPDNADPVTMNADAQAGGDNFGIQSGSGGGSSGVGRGGAGNATYGRYLGYLMQQAISRDDKVKRLAFQLQVNVWLANDGRLEKVELVRGSGNEEADAAVLDALRRIGKVDQAPPPSLDFPARVLIQGRRPGA
>NC_010943.1|WP_044570314.1|2746954_2748700_-|putative-porin
MNDHVRARTDSRRLRPARRALLCCAVLLSLAAPAGAMAAETTMVKLIKGLIASGALKPEDGQALLVQAEAEAAAAQRGTVAAPSAASGGVALEAGDVRVPYVPQSVRDGIRDEVRQDVMAQAKSEGWAAPNEVAEWTKRIKVTGDMRVRSESRFFSERNSDIVSNWSSINSGNGFDTNTNTNLQLPPLLNTRQDRRNLWRIRARLGIEATIGQHTTAGVRLASGSSNGPVSTTEQLGGGLSKKDVWLDQAWLAYSPADWVTVRGGRFGNPFWTSDTLFSNDLNFDGLAANLKYDFDDGDLDLFGNLAVVPLEYTSDSSPSQSKVKTPNENKWLSGAQVGVNWRFNDENTLRAALGYYDFKNISGRLSSPCALYAGAVGCDTDWSRPAFMQKGNTLMLIRDIARNPLDPANTPTPQYVGLASAFRLATLNLRWDTQLAQGVGLRLDGDYIRNLAYDKQAMFSRAQNGIVNNYGAGGTASIDTFRSGDTAWMVQATFGATELKEKGQWQALLGYKHIEADALPDAYNDPNFHLGGTNARGYYVGGAYALDARSWISGKWMAAKEVSGAPLSIDVFQLEFNTGF
>NC_010943.1|WP_012480442.1|2756302_2757217_+|IS110-like-element-ISStma6-family-transposase
MFGIGIDVSKATLDVAVHGEQFRQFSNDKRGFVRLIRWLKTWPIKQVVLEASGGYERAALDVLHAAGLPMVRINPARARRFAQGTGRAAKTDRLDATVLAQMAHLLPLTRYVPPAPWQQRLAEFAQCRRQLVQMRVSEMQRLRRLVDPDLIAMKQRHIAQLSDDLKQLDKAIAEQLEGQPGWKNIGALKGVGPILISTLACELPELGSLGSKAIASLVGLAPMNRESGTWQGQRRISGGRAVVREALYMAALTAIRYEPRLRAFYAGLKAKGKASKVALVAVMRKMLVILNARKRDAEVALSCP
>NC_010943.1|WP_012480443.1|2757749_2770133_-|filamentous-haemagglutinin-family-protein
MSHPLPSAVHPAAPMRRNHPMAWAIAVALGSMVAPASQAQQAFSPGWFAERGAAQGSAAQSGRMPNGVPIQFQLPAQQQDAARQKLQQSIDNLGTAAQAIALQQRLQEQARQARREAGFIVADGLGKDGLSVDQNPLTRGWLNARDAIQSQGSDGRVQVTVEQTADKAILNWETFNIGGNTTLNFLQNPDWAVLNRVNDPQARPSHILGQLKANGTVFVANRNGVVFGNNSQVNVRNLLAAAARISDAQFRDNGLYSPDASSSALSDAFGKVMVEQGARIATHEPTSATRGGGYVLLAGHSVENAGHIEARKGQVQLAAGDSFVIRRGVGTATNTSSTTRGNEIAPRFVAGSTAGSVRNTGLLRAREGDVTLAGRNVEQAGVAVASTTLAQRGTVHLLASTSDAGSSVTLADGATTAVLVEDDGKATVLDTQRNSLIKESAEQDAIRAGARSATFDNLSQHNDRRDQSRVEIVSGGNIHFSADSLTVATGGQIIADAAARSYVDDAARVDVSGAVGVQVSMESNNVQVKVQGNELRDALDNRDSGKLTSSEVWVDRRRLVHVPAGTGGYAGERWYAAGGLLEVGGYLDNQGHSIGEWAAQGGTVLLGGREVITHGGSRINLAGGSLDVQSGVIRQSWVRGVDGQVYRLDDAPAEMLFDGLYSGHEVKQERWGITETFRDPIVFAAQRVDNGYTVGRDAGRLIISAPTAVLDGKVETATFQGAQQNRRPDTALEGYAQAQTAVARNAQLYLGRYDGQGRSGVFGSDVRLDDKARTKAAWSLLAPVNEVRRGTVWLDIAELSAQQWGRIDLATADRIRIDGSLRLQAGGQLNLTGSEVELAGDIGIAGGQLSAGNLLDVQGRPTALLHDGRARTAIADGTRIDLSGEWSNASLATPRDASGAWTDGGRLSLGNSHDVAVGADSTVDVEAGAALDLRGKAHIGKGGSVSLQANSSTVTTDGSGRVQLGDGSRFSGRGQGGGSFSLGTGGQVRLGDADLAGTSLRLDPGLFGSGFAQYDINGHQGVEVADGARLVAALPGLRLTQDARMATDRASALAAWDAPLYSADPSSGRVSQRAGASISLRSERNSVGGDLRVGKDALVAVDPGQTISLLGAGNIDVEGTLRAKGGRILIDDVRPENALYAGQRTERTWRFAEGALLDADADAMSLPDSSGRLRGQVRAGGRIEIGGALDWETTAFVDNRPPEAFVVVERGARLQARGASAELDIDGQGRVRVDSDGGQIVLRSANALYLDGGMDAAAGGAGARGGTLGLAFGGSIHARGASDEVLRARAISLSQHSAPAQPLPATLEYGHAALSVEQLQAGGFDNLSVFGDIRAVGDVDLRLAQSLRIHGQGTSSLGMAVDAGLSSGLRLSAPYVRLAQARWRQMPGENLQGTAAVASSGPEDHALAVQAELIDIRDVTWLPGFKHVALESRSDVRLTNGIASSGNTSALMTAGSMDVTAARLYPTTGAIGTLVAGASAQTVQTADYWTDPDAVLRIHGTGADTKPAPESALGTLRLVAATVQQGGNVQAPMGTLQLGGLIQNGTVGSRVELLPGSVTSTSGAGLSLPYGGTVDGVDWRVGTRSLGSLTPAGISSMGVTLKANEIEVAPGALLDMSGGGELTGAAFVSGRGGSVDVLRTALADANPRYGFSASGNPVYAIVPGRAGTFAPSGEEGFAAPAVGQQITVPAGVPGLAAGTYTLMPASYALQPGAFRVELGATGTSGIAQPIATGTGTWRVSGQQRTALGTAISPLLTDILLTPAAVVRRHSGYNETSYNSFAQSVADRRGESRGWQTIDALGLTLALGEGAGRADTPAIRFAGTARFGAATDNGRGGTLTATLASPAVGSLEIVDGGAQSQARDRGATFSDDALNAFLPARMMIGGQFNQEASQVAVTGQARSVAIRSGVTLNAPEVLVAAASGGSGVLVEAGATLDTLSFASANANASATVPYQVSGGLLAVSNQRLNLITGTTGVEAGPVAIDIGGCQTACDGQTRLVSDGSIAVATDGALQMRDSASYGTRQLGLSMAALNLGSAEAIALAAAAGALPSGMTMNQSVLQQLLRGNDATGAPALDTLSLVARDSVNVFGSVDLDARDSATGRSGLQTLVLGAQAIRGYGAATDRARILVDTLVWDGSLAASQAPGSDASVPPADPMVDRLGAGQLDIFTRQLQLGRAPLSRPSSEVPANRQVLGFSALNLSASEQLSFSAQGTLDVFQQRGDYLADKGWQYSGGSLGIDTPLLTADPAARLRVRTGGDFRLQGGTGKAGGDALGSELSIDANRITLDSTIALASGRLSANARQGITLGSRAALDLAGRKVSLYDVDKFSWGGDVLLSSDTGDIRADAASRIDVSARNNRGGRLTVTAMAGRADLAGVLQGAATGRYDAGGTLVPYDGGELVVRARQLQDFAGLNQRLTAGGVVGGRSFQIGEGDLRIGDEVKARRVDISVDAGSLTVAGRIDASGEQVGSIRLYARDQLQVDGTLDAHGTGLRVDSHGKIIDSPNRATITLGSAEGAVGLGSAAQLDLRAGSDVTVGGRPGQNDGTPRGTLKIDVPRLGSNDAAIAAATGLRIDGAADIQLNGVRRYDDAPLAATADVRGNRAQLVTQQWLDQVVDPHSVAWIDAALDNADLQQRTRALGDVRLRPGVQVLARRSDANPDGDLTIAGDIDLSGYRYGPEANRADPSRRGFGESASLVLRAEGNINVYGSINDGFAPPPSTPDEGGWQLYEGRNGSAGQTPFGGGLVVPVDGVKLQPGTEFQAGTRLNYDVPVESVTLPVGTVLPAPMVISQNLRLPAGTVLGAAVTTDSGQTLAAGTVLQEPLVLAAGARLGAGFRLRSAVQMAAQEWPAGATLPVALRLAREVELKVGAYIPSLTKVELPGNGPVNLRPADAGGNQGRNWALAPMLAEGTTSWDLTVVAGADAGAADPRSRRWGSEGSVVLADTHQGSIGTVKTEIIWVGDRALTERASLDWIGDTSYAGRPIAELADMFGFTEDEFCAMSADYCGPAPRQVAAQGSLDYWGDESYVGTPAKDFAAMFGMTEDEFCSTAPTYCAGGGTQTEVTTYGKRAGTPAWSVLRTGKGDLELLAAGDVVMKSGFGVYTAGAPTTLGEGRDAAFNSPRAAAPRNTALLGPNLVPGSYDAALAGYQAWYPDHGGNLRVEAGRDIVGDVWTGRAESGTSERDWALYSSAAVGNWLWRQGTGSTTGVEPVPTSWWVNFGAYTNVSAAAGASPRMVGFTGFGTLGGGNLTLEAGRDAGVRDAIGDALDSTIAPRSGAIIAAVGSTGRVSDGQLHLTGGGDLQLRIGGALNPNLRATFSSLNASRAGQNLDLNGTFSNLRGSLQLDAGRIGAMGVTLESYATLGQLRAADLFAADAARPMGGPVLVLGDSVAQLQARGDVVLGGVADAGRVPLANYSAVLLDDGARAAGSTWFSLWTANTAVDLFSAGGDLAPGLAGPENVTGSNLWREQVQLVVRGGDDLLNYWLYPSRFSAIAAQGDIKLDRISTTPGTQDVILLAPSATGRLDVLAGGGIFAQPGATQIARSASDARLPGPFDPAFMAEQGDSAGNVTRTRHNLSVDGNIASPDASLPLFAFGPNTPLSSVSAALAPSRFYAVQGDIIGLATGARRTLNPNAGQRTQLNWFEAAGAVQLRAGRDILGVSMTALNTAPTDITVAAAGRDIVHLNATIAGPGNTEISAGRQLRQEDAGSIVSLGGIVQGDTRPGASIALTAGNQQIDFAALRARYLDPVNLADPAQSLASQPGKAVKVYNQELKQWLQQRFGVAADGDGALAAFDALPQEQQRIFLRQVYYAELREGGREYTDVEGPRFGSYLRGREAIATLMPDRNAAGATIDRTGDIVMYGGSGVRTEAGGNIELMAPGGQIVIGVQGVVPPASAGLVTQGQGDIRLFSQDSVLLGLSRVMTTFGGDILAWSEQGDINAGRGSQTTLLYTPPRRVYDGWGNVILSPQAPASGAGIATLNPIAEVRPGDVDLIAPLGTIDAGEAGIRVSGNINLAALQVLNAANIQVQGESKGLPVLASVNVNALASASAAANSASQAAQDVMRKSQDEARRNQPSVISVQILGFGSGTSAINPPARGNTANSGYDANSAFQFPQASRDEGTQRR
>NC_010943.1|WP_012480444.1|2770332_2771508_-|substrate-binding-domain-containing-protein
MIKYKTLAALVATALLATVGAASAQAVTGGGASLPADLYKGSSDSILPANFTYAVTGSGTGKKAFLENNSLLFSTTGTVHFAGSDSVLSSTELSTYTTNFNQPTNANRYGALIQVPSVATSVTIPFNKAGSAVDLSVAQICGVFSGAISDWSTIDANRSGPIQVVYRPESSGTSEMFSRFLTAACAAENAGTSNLVGGKFAIKSTFADLYKRDANGNLPAFLVAAPATGGTSLYNAVYAAEGRIGYVGPDVIPSVTDATKVAKVKGFSPDQVSVQATLDTVAPPTGTAAEDPANWVPVFGNPSAGYPIAGYTNLVIGQCYKDSSVATSLRGFLARHYPATYTVAYEKSITDHGFIPLTKAWRDAIRNRFVLASSTAGLNNPSTCAGIGRPL
>NC_010943.1|WP_012480445.1|2771932_2773132_-|type-II-secretion-system-inner-membrane-protein-GspF
MALFDYQAANAQGRIEKGQLDADSPRGARQLLRGRGLTPVQVSAARSAGSGWGARRLSASELAWATRQLASLLAASLPLEGALSAVIEQAERPHVAQALTAVRADVRAGQRLTVALAARPRDFPPIYRALVGAGEDSGDLARVMERLADYIEERNALQAKVLTAFIYPAAISLVSVAIVIFLLSYVVPQVVTAFVQARQTLPMLTQVMLAASAFVRSWGVWVGLGIAALVVTWRLALRKPELRLRWDAMLLRLPMVGRFVLGVNSARFASTLAILLDAGVPLLRALEAARQTLGNALLARCADDVSARVREGAALGAALKVQKVYPPILVHLVASGEKTGSLAPLLDRAAQTISREIERRAMALTALLEPTMILVMGGVVLTIVLAVLMPIMEMNQLVQ
>NC_010943.1|WP_012480446.1|2773139_2774573_-|type-II-secretion-system-ATPase-GspE
MSASAPLPYAWVRSHGVMLSEVGGEPVLLGTADTAAWAVAELRRRHGPLPFQALDAATWQQRLGEQYRDGGDAAAVVGAAESEVDLDRLMQDMPEVTDLLDAQDDAPVIRMINALLAQAARDGASDLHIEPFETHSVVRYRVDGTLRDMVQPRRALHAALVSRIKIMAHLDIAEKRLPQDGRIAIRVGGRPLDIRVSTVPTAHGERAVLRLLEKDAGRLQLQRLGMADDTLATFTGLIRQPHGIVLVTGPTGSGKTTSLYAALGQLDSSTSNILTVEDPVEYDFAGIGQIQVNARIGMSFGTALRAILRQDPDTIMIGEIRDLETAQIAVQSSLTGHGVLASLHTNDAISAVTRLADMGVEPFLLASSLRGVLAQRLVRRLCTQCRRAEVDGEGRTVWRAVGCAACANSGYRGRTGIHELFVVDDRVRALIHEGQGEPALREAARRAGMRTLRQDGQRWVDSGVTTLEEILRVTGDD
>NC_010943.1|WP_012480447.1|2774569_2776948_-|type-II-secretion-system-secretin-GspD
MRARCLACSTALALIVCMAHAPALVLAQDARDEPVQLNLVDTDIGGVLRMAARFTGRQFLVDPRVTGKMTVVSDGPVSRTQAYQLLLGALRMRGFAVVENGGVSRVVPQADAKLLGGRVGSGGAGGEIATRTFALRYENAAALVAVLRPMISPDNPITANPGNNTLVITDYADNLERIARVIASVDTPAGMDTDVVKLQQGIAVDVAAMVAPLLDAQGAEPTQKVVVMADPRSNSVLLRSSSPGRTRLARQLVEKLDRAQDESGNLHVVYLRNAQANQLAGVLRGVVAGQSDAPAMGSNEGITPLPGDASHSTPAQPSQPQQAKPGGNALESQRLDPSRRDPIDAGSTGFSQNGISVQADVATNTLLISAPEPVYRNLRRVIDQLDQRRAQVLVESLIVEVNQTDAAELGVQWMLGNGRTFGGTHFGGTTGGSGLNTTARTTLDVLPKDGLKIGVIDGTINLPGVGQILNMKALANALQSKGGANILSTPNLMTLDNEAASIMVGQTVPFVSGRYVTDGGGGSNNPFQTIVREDVGLKLRVRPQISEGGTVKLDIYQEVSSIDAQSANSTAGIITNKRALDTSVLLDDGQIMVLGGLLEDSVSHGRDAVPGLGKIPVLGALFRSDTRKRAKTNLMVFLRPHVVREPAAGQRLTRDRYDYMRNAQAGAQPAQSWALPALSAPQLPPQDLSVLGQGNARDDQGQPLQNSSLAALYPSGDGDAQLVQFAQGLDPARASQGVAQVRALGLQAYAEATPGESGQRLRVRLPRDPATLDPALQQLRGLGYTPELVIGP
>NC_010943.1|WP_012480448.1|2776944_2777472_-|type-II-secretion-system-protein-M
MTTRTLWLGEGLVGLQHRWQRLPPRDRLMLWVMVVALLVAGLWSLWLEPLLKQRTYWQAELPRLQAQSRALAPLLRARERQQLAQGQHPTLAGLRDGIKTAGLAAGLHIEARDGRWHLQVQAVPADALWNWLLPVLADPAIELQQLQLTRTGDANMPAARISGNIVMVATAGAHP
>NC_010943.1|WP_012480449.1|2777468_2778632_-|general-secretion-pathway-protein-GspL
MNVQLRVRLPALEHLRADSAVDWAQLHKGEVLAHGRETLATLGLRHPQAAVRACLDPNDLILLELQLPPLSGRRLQSALQGEVEAMLLDDLQEVALAHGAQAADGTVPVAWLGQQAIAEAQQLLGSCGLQLQALYPTPLLLPWQDGQATLQVSGEHLLVRSGRDRGFVQWYGGRDACVVMQALAVRLQQAGVLAVQWIDSVPPTWPDSLPATAVTHERQTSGPLPGWSLPLPGAGRKAPRLAIGLALAAVLLAALGLQLQVSRSRIEGEALQRDMARQFSARFPEITDVVDPVLQARRALAVPLPAPPLPALQRQVASTLQAVPELAGQVRSLHYQPGQLDMELDADAQALADDPQRLEHWQQAVQAQGLQLAREAGGHLRVSGAGQ
>NC_010943.1|WP_005409889.1|2778628_2779534_-|type-II-secretion-system-minor-pseudopilin-GspK
MSARMRSVSSVRQCGMAVIVALLVVALVAVIATALLTRQSAQLRALRGDQLRVQVRMAVDATLERAAQQLREDVKEQLTTVRSGRWARPLELQAPLPVQLQLVDAQSMFNLRNLLAHGRPDPEARRAFIALCAGQGLGQGACASAADHIQARLRDGDMQAQAPLPRESLIEQALPGADPVALQALARRTVVLPAQTLVNANTSDLRVLQAVTPVVEPARLQALLGERDAGHWLLNRGDIANRLQLSNEQMAVLPLGIHSEWFLAVGQVQADGSAVDFRALLWREYRDDGVRVQRVWTRIGA
>NC_010943.1|WP_005409890.1|2779543_2779981_-|type-II-secretion-system-major-pseudopilin-GspG
MARQVRGRRARQQGFSLIEIMVVVVIIGILAALIVPRLMDRPDQARVVAARQDIAALMQALKLFKLDNGRYPSAEQGLQALVKPPQGGGAMPVTPYLDRLPNDPWGHPYQYQIPGTHGDIDVFSLGADSKPGGDAGNADIGSWQL

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Crispr_ID: NC_010943_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010943_8

2804788-2804866

Orphan

Consensus_repeat	Method
TTTGGTAGTGCCGGCCGCTGGCCGGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010943_8

>merge|NC_010943|8|2804788-2804866|CRISPRCasFinder
TTTGGTAGTGCCGGCCGCTGGCCGGCAGCACCCTCCACCCATCGCGCACCGTTTTGGTAGTGCCGGCCGCTGGCCGGCA

>NC_010943|8|8|2804788-2804866|CRISPRCasFinder
TTTGGTAGTGCCGGCCGCTGGCCGGCA	GCACCCTCCACCCATCGCGCACCGT
TTTGGTAGTGCCGGCCGCTGGCCGGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_010943.1\|WP_012480468.1\|2807131_2807839_-\|respiratory-nitrate-reductase-subunit-gamma	unknown	unknown	gnl\|CDD\|376889
NC_010943.1\|WP_043396264.1\|2807835_2808516_-\|nitrate-reductase-molybdenum-cofactor-assembly-chaperone	unknown	unknown	gnl\|CDD\|185014
NC_010943.1\|WP_012480472.1\|2813938_2815357_-\|NarK-family-nitrate/nitrite-MFS-transporter	unknown	unknown	gnl\|CDD\|184994
NC_010943.1\|WP_012480470.1\|2808515_2810060_-\|nitrate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|224063
NC_010943.1\|WP_012480467.1\|2806228_2807128_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|131979
NC_010943.1\|WP_012480473.1\|2815502_2815868_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012480460.1\|2794212_2796450_-\|1,4-alpha-glucan-branching-enzyme	unknown	unknown	gnl\|CDD\|139075
NC_010943.1\|WP_044570336.1\|2803464_2804679_-\|coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236430
NC_010943.1\|WP_012480462.1\|2798839_2800369_+\|sulfite-reductase-flavoprotein-subunit-alpha	unknown	unknown	gnl\|CDD\|223446
NC_010943.1\|WP_012480459.1\|2792500_2794216_-\|malto-oligosyltrehalose-trehalohydrolase	unknown	unknown	gnl\|CDD\|274114
NC_010943.1\|WP_012480466.1\|2804873_2806205_-\|NarK/NasA-family-nitrate-transporter	unknown	unknown	gnl\|CDD\|225133
NC_010943.1\|WP_012480475.1\|2816515_2817016_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|238385
NC_010943.1\|WP_012480461.1\|2796446_2797973_-\|glycogen-synthase-GlgA	unknown	unknown	gnl\|CDD\|234809
NC_010943.1\|WP_012480474.1\|2815864_2816407_-\|molybdenum-cofactor-guanylyltransferase	unknown	unknown	gnl\|CDD\|133000
NC_010943.1\|WP_012480471.1\|2810059_2813866_-\|nitrate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|227346
NC_010943.1\|WP_012480463.1\|2800568_2801237_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213264
NC_010943.1\|WP_012480464.1\|2801913_2802657_-\|molybdate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270255
NC_010943.1\|WP_005409908.1\|2801226_2801910_-\|molybdate-ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226629
NC_010943.1\|WP_005409905.1\|2798414_2798843_+\|PAS-sensor-domain-containing-protein	unknown	unknown	gnl\|CDD\|131984
NC_010943.1\|WP_010485317.1\|2802676_2803453_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|183004

Protein	Function_ID	Function_description	E-value
NC_010943.1\|WP_012480468.1\|2807131_2807839_-\|respiratory-nitrate-reductase-subunit-gamma	gnl\|CDD\|376889	pfam02665, Nitrate_red_gam, Nitrate reductase gamma subunit. This family is the gamma subunit of the nitrate reductase enzyme, the gamma subunit is a b-type cytochrome that receives electrons from the quinone pool. It then transfers these via the iron-sulfur clusters of the beta subunit to the molybdenum cofactor found in the alpha subunit. The nitrate reductase enzyme, EC:1.7.99.4 catalyzes the conversion of nitrite to nitrate via the reduction of an acceptor. The nitrate reductase enzyme is composed of three subunits. Nitrate is the most widely used alternative electron acceptor after oxygen.	6.60347e-98
NC_010943.1\|WP_043396264.1\|2807835_2808516_-\|nitrate-reductase-molybdenum-cofactor-assembly-chaperone	gnl\|CDD\|185014	PRK15054, PRK15054, nitrate reductase molybdenum cofactor assembly chaperone.	6.97876e-57
NC_010943.1\|WP_012480472.1\|2813938_2815357_-\|NarK-family-nitrate/nitrite-MFS-transporter	gnl\|CDD\|184994	PRK15034, PRK15034, nitrate/nitrite transport protein NarU; Provisional.	4.5318e-171
NC_010943.1\|WP_012480470.1\|2808515_2810060_-\|nitrate-reductase-subunit-beta	gnl\|CDD\|224063	COG1140, NarY, Nitrate reductase beta subunit [Energy production and conversion].	0
NC_010943.1\|WP_012480467.1\|2806228_2807128_-\|peptidylprolyl-isomerase	gnl\|CDD\|131979	TIGR02933, Putative_peptidyl-prolyl_cis-trans_isomerase_NifM, nitrogen fixation protein NifM. Members of this protein family, found in a subset of nitrogen-fixing bacteria, are the nitrogen fixation protein NifM. NifM, homologous to peptidyl-prolyl cis-trans isomerases, appears to be an accessory protein for NifH, the Fe protein, also called component II or dinitrogenase reductase, of nitrogenase. [Central intermediary metabolism, Nitrogen fixation].	4.06053e-25
NC_010943.1\|WP_012480460.1\|2794212_2796450_-\|1,4-alpha-glucan-branching-enzyme	gnl\|CDD\|139075	PRK12568, PRK12568, glycogen branching enzyme; Provisional.	0
NC_010943.1\|WP_044570336.1\|2803464_2804679_-\|coproporphyrinogen-III-oxidase	gnl\|CDD\|236430	PRK09249, PRK09249, coproporphyrinogen dehydrogenase.	3.50008e-32
NC_010943.1\|WP_012480462.1\|2798839_2800369_+\|sulfite-reductase-flavoprotein-subunit-alpha	gnl\|CDD\|223446	COG0369, CysJ, Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism].	9.34499e-121
NC_010943.1\|WP_012480459.1\|2792500_2794216_-\|malto-oligosyltrehalose-trehalohydrolase	gnl\|CDD\|274114	TIGR02402, Malto-oligosyltrehalose_trehalohydrolase, malto-oligosyltrehalose trehalohydrolase. Members of this family are the trehalose biosynthetic enzyme malto-oligosyltrehalose trehalohydrolase, formally known as 4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase (EC 3.2.1.141). It is the TreZ protein of the TreYZ pathway for trehalose biosynthesis, and alternative to the OtsAB system. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_010943.1\|WP_012480466.1\|2804873_2806205_-\|NarK/NasA-family-nitrate-transporter	gnl\|CDD\|225133	COG2223, NarK, Nitrate/nitrite transporter [Inorganic ion transport and metabolism].	2.00871e-125
NC_010943.1\|WP_012480475.1\|2816515_2817016_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|238385	cd00756, MoaE, MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.	1.05284e-40
NC_010943.1\|WP_012480461.1\|2796446_2797973_-\|glycogen-synthase-GlgA	gnl\|CDD\|234809	PRK00654, glgA, glycogen synthase GlgA.	0
NC_010943.1\|WP_012480474.1\|2815864_2816407_-\|molybdenum-cofactor-guanylyltransferase	gnl\|CDD\|133000	cd02503, MobA, MobA catalyzes the formation of molybdopterin guanine dinucleotide. The prokaryotic enzyme molybdopterin-guanine dinucleotide biosynthesis protein A (MobA). All mononuclear molybdoenzymes bind molybdenum in complex with an organic cofactor termed molybdopterin (MPT). In many bacteria, including Escherichia coli, molybdopterin can be further modified by attachment of a GMP group to the terminal phosphate of molybdopterin to form molybdopterin guanine dinucleotide (MGD). This GMP attachment step is catalyzed by MobA, by linking a guanosine 5'-phosphate to MPT forming molybdopterin guanine dinucleotide. This reaction requires GTP, MgCl2, and the MPT form of the cofactor. It is a reaction unique to prokaryotes, and therefore may represent a potential drug target.	2.14192e-39
NC_010943.1\|WP_012480471.1\|2810059_2813866_-\|nitrate-reductase-subunit-alpha	gnl\|CDD\|227346	COG5013, NarG, Nitrate reductase alpha subunit [Energy production and conversion].	0
NC_010943.1\|WP_012480463.1\|2800568_2801237_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213264	cd03297, ABC_ModC_molybdenum_transporter, ATP-binding cassette domain of the molybdenum transport system. ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.5546e-70
NC_010943.1\|WP_012480464.1\|2801913_2802657_-\|molybdate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270255	cd13537, PBP2_YvgL_like, Substrate binding domain of putative molybdate-binding protein YvgL and similar proteins;the type 2 periplasmic binding protein fold. This subfamily contains domains found in ModA proteins of putative ABC-type transporter. ModA proteins serve as initial receptors in the ABC transport of molybdate in eubacteria and archaea. Bacteria and archaea import molybdenum and tungsten from the environment in the form of the oxyanions molybdate (MoO(4) (2-)) and tungstate (WO(4) (2-)). After binding molybdate and tungstate with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ModA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.9034e-78
NC_010943.1\|WP_005409908.1\|2801226_2801910_-\|molybdate-ABC-transporter-permease-subunit	gnl\|CDD\|226629	COG4149, ModC, ABC-type molybdate transport system, permease component [Inorganic ion transport and metabolism].	2.44371e-92
NC_010943.1\|WP_005409905.1\|2798414_2798843_+\|PAS-sensor-domain-containing-protein	gnl\|CDD\|131984	TIGR02938, Nitrogen_fixation_regulatory_protein, nitrogen fixation negative regulator NifL. NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions].	1.13177e-22
NC_010943.1\|WP_010485317.1\|2802676_2803453_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|183004	PRK11161, PRK11161, fumarate/nitrate reduction transcriptional regulator Fnr.	9.63133e-56

>NC_010943.1|WP_044570336.1|2803464_2804679_-|coproporphyrinogen-III-oxidase
MSFHVDESEDTALQAALLRQPRHVLFPPADQFSTGFGESGWRAAMRASNEHLIPRGLTLGFQVGRGGRGVPPQAYLDTLLLALRLQADVLAEDREVVAMVLQLGLAETLPPPQLGQLLDAVPQHLRTVARPQVEVRLDAGSALAPAQLRAVGCTRLNVIDRADAPGPTLLAQARQVGFTARYYQLRVPGSEDAGFIERLHEVLAEAPERILLPAPCALPEYPSAVHWLQAWRLLRAAGYEPIGGDHYQRGDLPNPHGPGDGQRHCDLASVPRRDRSDFIGLGLSACSQIGEVFYRLEDELGEWRARLLAGHMGVSAGLILSEDERLVAEVAQSIACDHALDAAAFEWRNDEPFEECFAEQLPALSPLLARGWAQWDARVLRLAEEGRLLWRMMAACFRPAAAIA
>NC_010943.1|WP_010485317.1|2802676_2803453_-|helix-turn-helix-domain-containing-protein
MSSIPPSQGRLGRATPNPAAADDGDALHFCSTCAFSDACMSQGYDKTALGDLHVLVDHVGPFHAGDYIFRAGESFDSIAAVRAGMVKTFVDDSQGNEQVLGFSLPGEVIGLNAIHGSRFPCNAVALDTVHLCRISFPKLSLLATRMPGLQAKLFSLLSAEIGKVATLAANHRTEERMAAFLLDMSERYARRGFSATRFNLTMARTEIANYLRMAPETASRVLRRLSDDGIIAVKQREILLLQPERLAALAVADESDPN
>NC_010943.1|WP_012480464.1|2801913_2802657_-|molybdate-ABC-transporter-substrate-binding-protein
MKRAGLLLLGLLATVPAWAAELTVSAASSLTESFRELGAAYERAHPGTKVDFNFAASGVLLQQISRGAPVDVFASADETTMDQAQQQDLLAAGTREVFAVNALWVVVPPQAKAAPRTLKDLAGAGVQRVALGNPDSVPVGRYAKGALEAAGLWPSVQGRIITTQNVRQSLDYVARGEVDAGFVYATDAQAMPDRVRRAFAVPVAGRIAYPLAVTKASAQSAEARRFTAFVRSAPGQAILAKHGFGKP
>NC_010943.1|WP_005409908.1|2801226_2801910_-|molybdate-ABC-transporter-permease-subunit
MDLDWSALGLSLKVAGWATAINLVLGVALGALLARRRFPGRELLDSLLTLPMVLPPTVLGYYLLVLIGRNGPIGAWLQSWFGINLVFTWQAAVIAAAVASLPLVFKPARAAFEEVDGQLEQAARTLGVSEAAVFFRVTLPLAWRGILAGLLLAFARAMGEFGATLMVAGSIPGRTQTLSIAIYEAVQAGQDGKANALVILTSVVCIVILLLAARLVGGRRRELRDVA
>NC_010943.1|WP_012480463.1|2800568_2801237_-|ATP-binding-cassette-domain-containing-protein
MWLDLQVRRRLQAAGQDFVLDVSLQCTQRQVVLFGPSGAGKSLTLKAVAGLLRPGQGHVRLQGQTLFDAATAVDLPPQRRRLGYVFQDYALFPHLSVRQNVAFGLQKGWLNPRVGQRFDAVEQWLHAFRIDTVGDLLPSQVSGGQRQRTALARALVTQPQALLLDEPFSALDHDLRQHLRQELETVLDKTGIPLLLISHDPQDVAMFGQQVARVVDGRIVGN
>NC_010943.1|WP_012480462.1|2798839_2800369_+|sulfite-reductase-flavoprotein-subunit-alpha
MNALPTSTPFSRLLVGFASESGNARALAQRLGAELQPHGPQVLPFNDIDVASLGQGDVLLAISSSFGDGEPPANGEQFFETLRQVPTLSGLRYAVFGLGDTGYPSFCGFTKALDAALSERQAQPLLHRVDADLGYEQFFQQWQPVLGQVLDGDLSAGQHLHLQVTAYGEDNAFAAPILERRRLNSSDPAAWHLQLDIAGSGMAYRAGDTLHVVPENDPALLQALATWYGDTAAVAALHDRELRLLSKGVLRELAKLGGSEVLKGLLKVSQKRELEAYLHGLDLLDVLQDHATPDSVPLARLRELLSPRLPRAYSIASHPCDDQLSLCVREVRYPLRGRERFGTATGSLLHGGEHARVYCRSNPGFHLPDTGQAPLLLVGTGTGIAPLMGLMQELQANGCEREVHLVFGEKHRQHDYLYRDQLQDWHARGVLAGLHTAFSRDGAEKIYVQHVLQQRASEVRDVLARGGHLYLCGNKRHLEGAVREAIDAIGGEGRWDALRGEGRTHCELY
>NC_010943.1|WP_005409905.1|2798414_2798843_+|PAS-sensor-domain-containing-protein
MSYTPDNAQLLNAMQNVMVISTTDLQGNITYANDLFCTLTGFAREELIGQPHSIVRHPDVPKAVYKDMWDTIKAGKTWTGIVPNLGKGGVLYVVDTTVQPLFDADGNITSYISIRRVVNDLMQNYDLVEFSKEKFDDFYEAA
>NC_010943.1|WP_012480461.1|2796446_2797973_-|glycogen-synthase-GlgA
MARAVQSASSVATSPGSLVPIGTRRGHSQPLQLPELVQRVLFVATEMADFIKAGGLGDVAAALPRAVRGACDSRVLLPGYPEVLQRLPQLQRVGQVSARAGLPACGIGMAVQADGLPIYVLLSPELYEREGSPYVDGQGQEWKDNAVRFATLSHAAAEIAAGRAGLDWSPQLLHLNDWPVAMAAAYVRWDRTTVPTLLTIHNLAYQGLFPYALAPVLGVPVEHLDELHFHGQMSFLQGGITNATRLNTVSLRYAQQITAPDDGCGLHDLLARRAAGGHLSGIVNGIDASWDPRRDIHLKAHFGIGEWTGRATNAHAVRSAFGLAPSAGPLFAVVSRLVHQKGLDITCDVAPQIVAAGGQLVIIGGGEPQVEAQVQALARRYPGRVGAFIGFEEALARQMFAGADFLLMPSRFEPCGLSQMYAQRFGCLPIAHATGGLVDTVEDGVTGFLFHGANADGLRRCVERAMRTFRLPGLLQAMRRAAMLRPGGWDAAGRAYLALYQQTCQVAA
>NC_010943.1|WP_012480460.1|2794212_2796450_-|1,4-alpha-glucan-branching-enzyme
MSHDSLQPVALEDDSMATAGREEGVVAPVLDDLVHARPADAFAWLGPHQQPDGQRQLRVLVPHARRVEVIAGPERRWDLQPGPLPGLFEGAAGEAPVPLLALHFEQGVEQVHDAYSFGPLLDEALLQHFHAGDADAARQLGAVAMQVQGIDGVRFAVWAPNARRVAVVGDFNGWDGRRHPMRLRHTAGVWELFLPGVQAGARYKFRIVGADGRVMPDKFDPMARWAELPPATASRVPSAAPMQWHDDAWLAARRQAGTCTPLSIYEVHAGSWQRSDDGSPLDWDVLADRLIPYVAGLGFTHIELLPVSEHPFGGSWGYQPLGIYAPTARHGTPQAFARFVDRCHQAGIGVIVDWVSAHFPNDAHGLAGFDGTALYEHADPREGVHADWDTLIYNYGRNEVAAYLIGSALEWVERFHIDGLRVDAVASMLYRDYSRAEGQWIPNEQGGRENLQAVAFLRRMNQTLRERFPDVLVIAEESTAWPGVTAPVEQGGLGFTHKWNMGWMHDTLQYLGRDPVHRQHHHSEISFGLVYAFSERFVLPLSHDEVVHGKGALLAKMAGEPVQRLAQLRAYYGFMWAHPGSKLLFMGGEFGQGQEWSHDAALDWVQAASNEGQGLSRLVGDLNAVLRAEPALHRDERDERGFDWSVADDSRNSVYAFIRRDPAGSGRTLLVVSNFTPVRRDGYRVGVPQPGCWTERLNTDSGYYGGGNAGNLGAVHTEPRPMHGHAQSLRLTLPPLSTLYLQVDA
>NC_010943.1|WP_012480459.1|2792500_2794216_-|malto-oligosyltrehalose-trehalohydrolase
MTAVAPRLGAWPVAGEGVEFRVWAPDAGTVALCLQGVLRPMHRDPDGCHWLRTQASHGDRYRFRLPSGQDVPDPASRWQPDGVNGDSAVVLGTDGAHPTWQGHAWQDLVIYEVHIEAGGGFAALTAQLPMLAALGITAIELMPVAQFPGGRNWGYDGVFPYAPALAYGGPSALKAFVDAAHDAGLSVLLDVVYNHFGPQGNRLRDYACGFFRDDRSTPWGEAIDFRQPWVRRFFIDNALMWLRDYGVDGLRLDAVHAIDDDRFLQQLADEVRAAVPQAHLVLENERNQARWLRGAYQGQWNDDFHNALHVMLTGEQEGYYAAYAGRAEALLARCLAEGFAWQGEPDLRGDPRGEPSADLSPARFVVFAQNHDQVGNRAFGERLSMLTDPAPLRAALALTLLTPMIPLLFMGEPWQAQSPFLFFTDYAPPLDEAVREGRRREFSGFSAFADAAARARIPDPNDAATLQASYTPPGDDPWSQHWLRCTGEFLGLRRRYLQPGLLQARSLGARVLGQGAVQAGWQLPSGQWWIAINVGPSPVAHAMPAGECVVGPDAAAMLPAGGGALARWIAA
>NC_010943.1|WP_012480466.1|2804873_2806205_-|NarK/NasA-family-nitrate-transporter
MNQALAPASAGQQQRALWLSTFAFTVCFAVWMIFSIIGIQISQQLGLNDTQFGLLIATPVLTGSVSRVFLGIWSDQFGGRKVMVLVMLCGAVATWMLTYAQTYTQFLIAALCVGIAGGNFSVGVAYVSKWFPASKQGTALGIFGAGNIGSAVTKLLAPLVMVAAGWTMVAKVWAVALAVTAVLFFLFSKEDPSLEQRRREGVKPVPFAEQMAPLKNLQVWRFSLYYFFVFGGFVALALWLPHYLVGAYGMDVGHAGMLAACYSIPASLFRVVGGWMSDRMGARRVMYWTFGVSAICTFLLAYPDTEYVVKGIHGPIHFHLAIGVVMFTVLVFVLGFFMSLGKAAVYKHIPVYYPKHVGAVGGVVGMIGGLGGFILPIVFGALNDAVGIWSSCFMLLFVLVAAALAWMHFAIRRMERRHFPQIDRETDLPEAIDAAAAERVRGG
>NC_010943.1|WP_012480467.1|2806228_2807128_-|peptidylprolyl-isomerase
MGSLPKFLPITVIDSAAPVPAEAHSHHHDAAAQGPRSLGQPAPCRLFVDETAISEADIAREMQHHRAMRPEQSRAEAARALVVRELLRLEAQRLGLQAPEGNRVSDEEVLIQQLLEDAIKDRVPSDEDCRRYFEQNPERFRSPDRVRLRHILLAAPADDVAGRFAARTEGERLVGLLKESPHLFADFALRHSRCPSSSEGGDLGWLQRGQTTPEFDRQVFRLREGLAGFPVESRWGYHVVCVDAREEGQPQPFEAVLPQLRDYLELQVRQREVQAYLLQLQERYPVRGLDEIEAEADIG
>NC_010943.1|WP_012480468.1|2807131_2807839_-|respiratory-nitrate-reductase-subunit-gamma
MSYSLHQFAFQYYPYIAVAVLLIGSWARYDRAMYTWRTGSSQMLSDKGMRIGSNCFHIGILAILGGHLVGLLTPHAVYEHFITSSQKQMLAMVVGGVFGALCFIGISILLVRRLFNARVRATGSFGDTLVLVLLFAQLCLGLYSIRISSGHLDGGVMVQLAEWAQHIVTFRAGAADYIEGVSWVYKMHIFLGLTLFLIAPFTRLVHVWSIPISYLWRPYQVVRRRQATLRYGPRE
>NC_010943.1|WP_043396264.1|2807835_2808516_-|nitrate-reductase-molybdenum-cofactor-assembly-chaperone
MSVLKLVGVLLDYPREELWEHGEELLAACDDPALNATRRQQLRSFVQQLLATDALDAQAAWLASFDRGRSMSLLLFEHIHGESRDRGQAMVDLVETYRRNGFELDARELPDYLPLLLEFLAHRPGSEAREWLHHIGHIAGMLAARAAERELPHRVLFEILVEAGDGKADLQALRQRASEEVRDDTAEAMDRLWEEEAVRFGAEAPAEDCKPPVRSPARPSHREVQP
>NC_010943.1|WP_012480470.1|2808515_2810060_-|nitrate-reductase-subunit-beta
MKVRAQIAMVLNLDKCIGCHTCSITCKNVWTSREGVEYAWFNNVETKPGIGYPKEWENQEKWNGGWVRTGSGKLVPRAGGRWRMLAKIFANPDLPQIDDYYEPFDFDYQNLHTAKDSQHQPTARPRSLISGERMQKIEWGPNWEEILGSEFSKRSRDYNFDQVQKEIYGAFEKTFMMYLPRLCEHCLNPACVSACPSGAIYKREEDGIVLIDQDKCRGWRMCVSACPYKKIYYNWKSGKSEKCIFCYPRIEMGEPTVCSETCVGRIRYLGVMLYDADRIAEAASVAAEKDLYQAHLDIFLDPNDPAVIAAARKEGIPDSWLESAKQSPVYKLAIDWKLALPLHPEYRTLPMVWYVPPLSPIQSAAERGRVGMSGELPDVASLRIPMRYLANLLTAGDEAPVVRALERLMAMRAWRRARNVDGVEDTSVLEQTGLSIAQVEEMYRYLAIANYEDRFVIPTGHREYANDAFGERGGCGFTFGNGCNGDSPADLFGQRKTTTFVVDKGPNHRRKEVV
>NC_010943.1|WP_012480471.1|2810059_2813866_-|nitrate-reductase-subunit-alpha
MSYFLDRLQFFKRDPQTFADGHGFAKSEGRDWENSYRARWQYDKIVRSTHGVNCTGSCSWKIYVKNGLVTWETQQTDYPRTRPDLPNHEPRGCPRGASYSWYLYSANRLKYPLIRGTLLRLWREARKSKAPVDAWASIVEDKEKARSYKTRRGMGGFVRLQWEEANEIIAASNLYTVKQYGPDRVVGFSPIPAMSMVSYAAGARYLSLLGGACLSFYDWYCDLPPASPQIWGEQTDVPESADWYNSRYIIAWGSNVPQTRTPDAHFFTEARYNGTKTVAICPDYSELAKLTDHWLHPKQGTDAALAFAFGHVILREFHVDWPSQYFQDYCRQYSDMPMLVRLERRDDGRLVAGRFLRASELGGLGEANNPDWKTLAYDENSGQIVVPNGSIGFRWGEKGRWNIEEKASNGADTRLRLSLSEANDGIEAVSFPYFGGIESDGWTAAPAEEVLDRNIPVRRLATADGGETLVATVYDLLLAQYGVDRGFGGGNVASSFDDMVPGTPAWQERITGVSRAEVIEIAREFARTADKTHGRSMIIVGAGMNHWFHNDMNYRGLINMLIMCGCVGQTGGGWAHYVGQEKLRPQTGWQPLAFGLDWSKPPRHMNGTSFFYFNTGQWRYEKLQVDELLSPLADASKYGGSLADLNLRAVRMGWLPSTPQLDRNPLQLVREAEAAGVAPADYALGKFKDGSLDFAFADPDASQNHPRMMFIWRSNLLGSSGKGHEYMLRHLLGTRHGLQGKDLGEMGAVKPQEVKWRDEAPEGKLDLLVTLDFRMCTTALYSDIVLPTATWYEKDDLNTSDMHPFIHPLSKAVDPAWESRSDWDIFKEVARTVSEMAPGVLGVEKDLVLVPTLHDTPNELGMPFGVADWKKGECEAIPGQTMPSMTVVERDYPNLYRKFTSLGPLLDKQGNGGKGMSWDTKHEVEFLGKLNHTVHEEGVSQGRPAISTAIDAAEVILHLAPETNGHVAVKAWESLGTFTGREHTHLAVGKEHEAIRFRDIQAQPRKIISSPIWSGLEDDNVSYNAGYTNVHELIPWRTVTGRQQFYQDHEWMIDFGEAFMSYRPPVNTRTVEPLLNQRPNGNKEIVLNWITPHQKWGIHSTYSDNLIMQTLSRGGPIVWISEDDARSAGIVDNDWIELFNVNGAIAARAVVSQRVMPGMAMMYHAQERIINVPGSEISGTRGGIHNSVTRIVLKPTHMIGGYAQLAYGFNYYGTCGTNRDEFVIVRKMDKIDWLDDEQGSSSVAGAGRAGATDEQPAGASASASKEVV
>NC_010943.1|WP_012480472.1|2813938_2815357_-|NarK-family-nitrate/nitrite-MFS-transporter
MTVGSDPVVRSTASPGRVISDWTPEDPGYWERTGKRVATRNLVISIPSLLLAFSVWVLFSAVSISLPKIGFNFSTDQLFWLVALPSLSGATLRIFYSFVIPIFGGRRWTALSTASLLAPTLWLGFAVQNPATPYWVFVAIAILCGFGGANFSSSMSNISFFYPKQKQGLALGLNAGLGNVGVSVAQAVIPLVITVGVFGALGGAPQPAVEGGAPLFLQNAGFIWVPAIALCAIAAWFGMNDLTSARSSFSEQAVIFRRKHNWLMCWLYIGTFGSYIGFSAGFPMLVKSQFPDVNPLAYAFIGPLLGALMRSVGGSMADRWGGARLTFWVFALMIAAVFGVLHFLPSDGQGGNFYGFLLSFMALFVLSGIGNGTTFRMIPVIFRTLHERWSANDNAEGKATAAHQASIESAAVVGFSGAIGAYGGFFIPKSYGSSITLTGSPDMALYGFVVFYVTCLAVTWWWYYRRGAETPC
>NC_010943.1|WP_012480473.1|2815502_2815868_-|hypothetical-protein
MKVQLQDQSVRLRLDEAELARLLAGETVENMTRFGGIEGWGMAVSLHGGDQPVLLDGGTFCRLVLPRSAVEALAARLPCRDGLPFDIALEDGSQLQLQFDVDVRDSVRQRGVTRRSTASSV
>NC_010943.1|WP_012480474.1|2815864_2816407_-|molybdenum-cofactor-guanylyltransferase
MSVNGIVLAGGLSTRMGRDKALLPWQGRTLLEHMRGLLMQAGAREVWVSGNYPAFGGVPDRVARCGPLGGLYSVAMRMPDGPAWVVPVDTPLLPPRLLQQLRDGHRGPCTIFAGHPLPMLVDIDDACRNVLESMLGDPDGPRSLQALQRRLGVNSVALAPVDEAGLVNCNTPEQWEDVAS
>NC_010943.1|WP_012480475.1|2816515_2817016_-|molybdenum-cofactor-biosynthesis-protein-MoaE
MSEKIIAKVVDRAQAAIDPAEGIAAVSDPGFGGIDVFIGKVRDVNIGRLVTGITYDLFEPLVLNEFKRLAAEVEAAFGPKLKLYVAHAKGRLGIGDVAVVVAAGSPHRDEAFRACRQLIEVVKHQCPIWKQEHYEDGDSEWSEGCSLCHADSEPAHAHDHAHDHGH

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Crispr_ID: NC_010943_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010943_9

3201880-3201979

Orphan

Consensus_repeat	Method
GGTAGATGCCCACCTTGGTGGGC	CRISPRCasFinder

1 spacers

DEDDh,csa3

The CRISPR arrays of NC_010943_9

>merge|NC_010943|9|3201880-3201979|CRISPRCasFinder
GGTAGATGCCCACCTTGGTGGGCATGGATCCAGGACGGCGCCAACCAAGGTTGGCGACTACCGCGGTACAGCGCTCTGGTAGATGCCCACCTTGGTGGGC

>NC_010943|9|9|3201880-3201979|CRISPRCasFinder
GGTAGATGCCCACCTTGGTGGGC	ATGGATCCAGGACGGCGCCAACCAAGGTTGGCGACTACCGCGGTACAGCGCTCT
GGTAGATGCCCACCTTGGTGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_010943.1\|WP_005410242.1\|3202029_3202974_-\|5'-nucleotidase	unknown	unknown	gnl\|CDD\|377624
NC_010943.1\|WP_005413910.1\|3195079_3195742_+\|carbonate-dehydratase	unknown	unknown	gnl\|CDD\|238448
NC_010943.1\|WP_044570577.1\|3203985_3208962_-\|NAD-glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|377452
NC_010943.1\|WP_005410232.1\|3193737_3194037_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_005410233.1\|3194044_3194359_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012480763.1\|3195762_3196284_+\|3-hydroxyanthranilate-3,4-dioxygenase	unknown	unknown	gnl\|CDD\|183930
NC_010943.1\|WP_044570580.1\|3209212_3209869_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379522
NC_010943.1\|WP_012480765.1\|3197752_3199120_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|223727
NC_010943.1\|WP_005413923.1\|3215065_3215983_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|185110
NC_010943.1\|WP_012480767.1\|3201297_3201849_+\|DUF2939-domain-containing-protein	unknown	unknown	gnl\|CDD\|378575
NC_010943.1\|WP_012480771.1\|3211167_3214341_+\|multidrug-efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|273335
NC_010943.1\|WP_005410240.1\|3200555_3201242_+\|DUF2461-domain-containing-protein	unknown	unknown	gnl\|CDD\|274138
NC_010943.1\|WP_005410243.1\|3203021_3203795_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|179876
NC_010943.1\|WP_005410251.1\|3217330_3218260_+\|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|369777
NC_010943.1\|WP_012480766.1\|3199119_3200559_+\|exodeoxyribonuclease-I	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|236979
NC_010943.1\|WP_005410250.1\|3216028_3217177_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NC_010943.1\|WP_012480762.1\|3194366_3195005_+\|FMN-binding-negative-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377290
NC_010943.1\|WP_044570582.1\|3214494_3214788_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012480770.1\|3209868_3211152_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|169982
NC_010943.1\|WP_012480764.1\|3196446_3197721_+\|kynureninase	unknown	unknown	gnl\|CDD\|130873

Protein	Function_ID	Function_description	E-value
NC_010943.1\|WP_005410242.1\|3202029_3202974_-\|5'-nucleotidase	gnl\|CDD\|377624	pfam06189, 5-nucleotidase, 5'-nucleotidase. This family consists of both eukaryotic and prokaryotic 5'-nucleotidase sequences (EC:3.1.3.5).	1.21892e-153
NC_010943.1\|WP_005413910.1\|3195079_3195742_+\|carbonate-dehydratase	gnl\|CDD\|238448	cd00883, beta_CA_cladeA, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	5.8742e-108
NC_010943.1\|WP_044570577.1\|3203985_3208962_-\|NAD-glutamate-dehydrogenase	gnl\|CDD\|377452	pfam05088, Bac_GDH, Bacterial NAD-glutamate dehydrogenase. This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyze the reversible oxidative deamination of glutamate to ketoglutarate and ammonia.	0
NC_010943.1\|WP_005410250.1\|3216028_3217177_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	6.30209e-177
NC_010943.1\|WP_012480763.1\|3195762_3196284_+\|3-hydroxyanthranilate-3,4-dioxygenase	gnl\|CDD\|183930	PRK13264, PRK13264, 3-hydroxyanthranilate 3,4-dioxygenase; Provisional.	1.01068e-107
NC_010943.1\|WP_044570580.1\|3209212_3209869_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379522	pfam14246, TetR_C_7, AefR-like transcriptional repressor, C-terminal region. This family comprises the C-terminal domain of transcriptional regulators of the TetR family. It includes the AefR transcriptional regulator from P. syringae. It is found in association with pfam00440.	3.35951e-14
NC_010943.1\|WP_012480765.1\|3197752_3199120_+\|FAD-dependent-monooxygenase	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	7.38662e-39
NC_010943.1\|WP_005413923.1\|3215065_3215983_+\|hypothetical-protein	gnl\|CDD\|185110	PRK15188, PRK15188, fimbrial chaperone protein BcfB; Provisional.	0.00666421
NC_010943.1\|WP_012480767.1\|3201297_3201849_+\|DUF2939-domain-containing-protein	gnl\|CDD\|378575	pfam11159, DUF2939, Protein of unknown function (DUF2939). This bacterial family of proteins has no known function.	1.41513e-29
NC_010943.1\|WP_012480771.1\|3211167_3214341_+\|multidrug-efflux-RND-transporter-permease-subunit	gnl\|CDD\|273335	TIGR00915, Probable_aminoglycoside_efflux_pump, The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family. Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate].	0
NC_010943.1\|WP_005410240.1\|3200555_3201242_+\|DUF2461-domain-containing-protein	gnl\|CDD\|274138	TIGR02453, conserved_hypothetical_protein, TIGR02453 family protein. Members of this family are widely (though sparsely) distributed bacterial proteins about 230 residues in length. All members have a motif RxxRDxRFxxx[DN]KxxY. The function of this protein family is unknown. In several fungi, this model identifies a conserved region of a longer protein. Therefore, it may be incorrect to speculate that all members share a common function.	3.55639e-91
NC_010943.1\|WP_005410243.1\|3203021_3203795_-\|NAD-kinase	gnl\|CDD\|179876	PRK04761, ppnK, inorganic polyphosphate/ATP-NAD kinase; Reviewed.	2.02836e-157
NC_010943.1\|WP_005410251.1\|3217330_3218260_+\|metalloregulator-ArsR/SmtB-family-transcription-factor	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	8.59407e-24
NC_010943.1\|WP_012480766.1\|3199119_3200559_+\|exodeoxyribonuclease-I	gnl\|CDD\|236979	PRK11779, sbcB, exonuclease I; Provisional.	0
NC_010943.1\|WP_012480762.1\|3194366_3195005_+\|FMN-binding-negative-transcriptional-regulator	gnl\|CDD\|377290	pfam04299, FMN_bind_2, Putative FMN-binding domain. In Bacillus subtilis, family member PAI 2/ORF-2 was found to be essential for growth. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.	4.75832e-49
NC_010943.1\|WP_012480770.1\|3209868_3211152_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|169982	PRK09578, PRK09578, MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit.	4.42913e-87
NC_010943.1\|WP_012480764.1\|3196446_3197721_+\|kynureninase	gnl\|CDD\|130873	TIGR01814, kynureninase, kynureninase. This model describes kynureninase, a pyridoxal-phosphate enzyme. Kynurinine is a Trp breakdown product and a precursor for NAD. In Chlamydia psittaci, an obligate intracellular pathogen, kynureninase makes anthranilate, a Trp precursor, from kynurenine. This counters the tryptophan hydrolysis that occurs in the host cell in response to the pathogen. [Energy metabolism, Amino acids and amines].	0

>NC_010943.1|WP_012480767.1|3201297_3201849_+|DUF2939-domain-containing-protein
MKKLTALAVLLVLALAAWWFGGPYMAVRGLSKAIEERDTARLERYVDFPRVRSSLRAQLNDYLVRQAGPDVAASPFGALLYGLGDQLGGAAVETMVTPTGIGAMLQGHVLWKRGRNELQGGDAFGATEPARPLKNAEHHFEALDRFVIDVDRGPDQPPMKVVLEPQGLRWKVVDLQLGMSATP
>NC_010943.1|WP_005410240.1|3200555_3201242_+|DUF2461-domain-containing-protein
MSTYFSDASFKFLRSLARHNDKAWFNDHRQQYEDHVRQPFLRLLGDLQPALAEVSEHFRADTRGVGGSLFRIHRDARFSNDKSPYKTWQGARLFHERRREVAAPSFYVHLQPGESFVGAGLWHPEPETQRRVRHFILDNPGSWKAAAHAPALRKRFDFEESEKLVRPPRGFPADFEFIDDLKHRNWVMWRSLDDATMTGPRLLSTLGKDLAGLGPFVDYLCAALDLEF
>NC_010943.1|WP_012480766.1|3199119_3200559_+|exodeoxyribonuclease-I
MADSFLFYDLETFGQDPRRTRISQFAAIRTDADLNEIDTPVSFFVRPADDLLPSPMATLVTGITPQQALAEGISEAEAFDRINEQLSRPGTCALGYNTLRFDDEFVRYGLFRNFHDPYEREWRNGNSRWDLLDMLRLMRAMRPDGIQWPLREDGATSFKLEHLAEANHVREGDAHEALSDVRATIGMARLFKQSQPRLWDYALKLRDKRFVGGLLDVAAMKPVLHISMRYPASRLCAAPVLPLAVHPTINNRVIVFDLEGEIDDLLELPAEVIAQRLYMRASELPEGVARVPLKEVHLNKVPALIAWNHLRADDHARLGLDVAAIEAKVERLRAFAPQLAEKARQVYNQPRAATVADVDASLYDGFLGNGDKPLLALARTTAPEQLAALEGRFRDPRLPELLFRYRARNHPDSLAPPERQRWQDYRRQRLLGDGGLGELNLPQYQQQLDALAAEAPDDTRRQALLQSLRDWGQHLQETL
>NC_010943.1|WP_012480765.1|3197752_3199120_+|FAD-dependent-monooxygenase
MIAHASRSLSIIGAGLAGSLLAILLSRQGWRITLYERRGDPRVADYESGRSINLALAERGRNALRQAGVEDEVMARAVMMRGRMVHPREGEPQLQRYGRDDSEVIWSIHRSDLNTTLLELAEQAGATVHFHRRLHTVDFDAGYARFIDDRDDSPHDIRFDTLIGADGAGSALRAAMNRRAPLGEDIAFLDHSYKELEIPPADDGSFRIERNALHIWPRGHYMCIALPNHEGTFTVTLFLPNQGDPSFATINTGAQAEALFAREFADTLPLIPNLRADWEQHPPGLLGTLTLDRWHQQGRAVLIGDAAHAMVPFHGQGMNCAFEDCVALARHLMEADDLEGAFAAFEAERKPNARAIQQMALENYLEMRDRVADPAFLLQRELEQELQRRWPTRFVPHYTMVTFLHTPYAEALRRTELQRDMLVAATTGHDSLDNIDWAALEAQIHAQLPVLEGAH
>NC_010943.1|WP_012480764.1|3196446_3197721_+|kynureninase
MSDLLSRTHAIALDAADPLRPLRNEFLIPRHGGGEQTYFVGNSLGLQPRGAQAAVQEVMKQWGELAVEGHFTGPTQWLSYHRLVSAQLARVVGALPSEVVAMNTLSVNLHLMMVSFYRPTAQRPVILMEAGAFPTDRHAVEAQIRFHGFDPAECLVEVQPDEANGTISLTAIERAIAEHGPRLALVLWPGVQYRTGQAFDLDAITRAARLQGARIGFDLAHSVGNLPLRLHDVAPDFAVWCHYKYLNSGPGAVAGAFVHERHHRDTTLPRFAGWWGHEEATRFQMAPQFTPAIGAEGWQLSNPPILGLAPLRASLDLFERAGMEALRSKSLALTGMLEALVRARLSGVLDIITPAEPQRRGCQLSLRVIGGRERGRALFEHLRGIGVLGDWREPDVIRISPTPLYNRYLDVHHFVEEVEAWAGL
>NC_010943.1|WP_012480763.1|3195762_3196284_+|3-hydroxyanthranilate-3,4-dioxygenase
MPASPINLHAWIEENRHLLKPPVGNKMIDNGDFIVMVVGGPNSRTDYHYDEGPEWFYQLEGEMVLKVQEDGAVRDIPIRAGEIFLLPARVPHSPRRPPGGIGLVVERKRLPHEKDGVIWHCERCNHKLHEEFFPLQNIETDLPKVFARYHASLELRTCSQCGHVDPLPVPAAG
>NC_010943.1|WP_005413910.1|3195079_3195742_+|carbonate-dehydratase
MKDIHRLLQNNRDWADRIAKEDPEFFQQLSKQQHPEYLWIGCSDSRVPANQIIGMAPGEVFVHRNVANVVAHTDLNCLSVVQYAVDQLKVKHILIVGHYGCGGVHACLHNTRVGLADNWLRHVGDVVQKHQGILDAIEDDELKHARLCELNVIEQVANLCRSTIVEDAWARGQKLMVHGWVYSLKNGRVSEMGIDVGGPEELKPAYEKALSYVPRQGRRD
>NC_010943.1|WP_012480762.1|3194366_3195005_+|FMN-binding-negative-transcriptional-regulator
MFTPRAFAETDLLWLDRLLARDPFVTVLTPGSDGLPELTRMPVLYRRDGDQIELRGHWARANPQSRHSGAAKVLVDGPHGYVSASWYPDKEPAARVPTWNYAAAELRGQLQTFDDADALAELVGAISDHFEASAGQAWRFDATRAEHGPELRAIVGFRFQVEHVQLKLKLSQNHPDANQQAVIAALEALASPSSHELAQWMRWHREQSASSG
>NC_010943.1|WP_005410233.1|3194044_3194359_+|hypothetical-protein
MNDITASRDSWWLASLGNTLIWARLRVRPAGTAEVLDSDGNTLSYDSEDTARSQLFDAEFVEYDGLDEEDALVRGFSLHEVQPPQADSDEGLRGRMVQSLGGRA
>NC_010943.1|WP_005410232.1|3193737_3194037_+|hypothetical-protein
MTLFFALCFVGVAVAGFSAFVIFWPLTLVHVRDRHPALAARFGSGAFLKPDALAWLLRRDYRQQPDRSLSGLATPAWVSLLTLLAGLGMAALLWLASLW
>NC_010943.1|WP_005410242.1|3202029_3202974_-|5'-nucleotidase
MGDNSPRLLTVAVTSRALFDLEESHALFESDGVAAYAEFQRQHEDDILGPGVAFPVVRKLLALNQGASPENPRVEVILLSRNSADTGLRIFNSIQHYGLGIIRATFTAGEPTWPYVKPFGTDLFLSANPESVRSALRHGIAAATILPKPPGETAAAAADQIDTGRPAGQLRIAFDGDAVIFGDESERISREQGVEAFGRHERERAREPLSGGPFRGFLSALHTLQEVFPAGESAPIRTALVTARSAPAHERVIRTLREWGVRLDEALFLGGRHKGPFLQAFGADIFFDDSQHNIDSAREHVAAGHVPHGVANEG
>NC_010943.1|WP_005410243.1|3203021_3203795_-|NAD-kinase
MSDTPRIAFLASTAEPAQMARAAMISRYGDHAPEQADVLCPLGGDGFMLQTLHRHGHLGKPVFGMKLGTVGFLMNQYRGDDDVQARIARAEPANLRPLEMVALTESGTSTGSLAYNDVSLLRQTRQAAHIGIDLNGQERVAELIGDGVLVATPAGSTAYNYSAHGPVLPLGSHTIALTPLAPYRPRRWRGAILKADTEVRFRVLDPYKRPVSVTADSHETRDVVEVTIRESKDRRVTLLFDPEHNLEDRILSEQFVF
>NC_010943.1|WP_044570577.1|3203985_3208962_-|NAD-glutamate-dehydrogenase
MKPQKTAAKTVKNKTKPAESEVAVTAGFSLEPVYTALRKRYPAAAQAEAVAFATDFYKRMESDEFPHHSAEEWAALAAETLEFARARKAGKANVRVFNPTAKANGWESPHTVLQIVNDDMPFLVDTVTMSLAEQGVGVHVLGHPVLRFTRDKAGKLVKVGEGDAESVMLLEIDRQPAEAMAAIEQAINKALDEVRAIVRDWQPMKDKALALADDLGKRQLPVDDASRKEAQEFLRWAADNHFTFFGYREYRVEKQGKEDVLAPLNDTGLGLMRGKDKSAARPVKTLAAQGLNATSGLKDALILTKTNARSRVHRAGYMDYIGVLEFDAKGKIIGEQRFLGLFTSSAYNRRPWEIPLVRQRHEHVMKQSGLAPASHSGKALRHILETLPREELFQSSEDELFRTAMGVLGLQERVRSRLFLRRDKYSRFISALVYLPRERFNTDVRLRIEAMLKDALHGEYVDSSVVLGESPLAQVHLIVRPKPGEMLDVDTAELEQKLAQVLRNWQDDLREALVARHGETEGLRIAARIGKALPAGYIEDNSTAVAANDVSQLDALTGPDDLRLSLQAVPRESGDGLRLKLYRQLDDIPLSDALPMMENMGLRVIAERPYRLSVDNAPVYVQDFEVESTAGAIDAASVDEAFGETFARVWHGDAENDGFNRLVLAAGLHWRQVAMLRGYCKYLLQTGVPFSQAYVEGTFARYPLLARLLVELFEARFDPATGHESKDDIAAGQAQLKAHFDVLAAGDDATLKVLKTVVDARKGDRDAQMQAARDALLKLMDRVSSLDEDRILRSFMGVIDATLRTSYYQTDANGQHGHVISFKFDSALVPDLPKPRPYREIFVYGPRVEGTHLRFGAVARGGLRWSDRREDFRTEVLGLVKAQMVKNTVIVPVGAKGGFFAKTPPVNGDRDAIFANGVACYKLFIQGLLDITDNIVNNKIVPPVDVVRHDMDDPYLVVAADKGTATFSDIANGLAIAHGFWMGDAFASGGSVGYDHKGMGITARGAWESVKRHFRALGRDSQTQDFTAVGVGDMSGDVFGNGMLLSRHIRLVAAFDHRHIFLDPNPDAATTFVERERLFTVPRSSWADYDAKLISKGGGVYPRSLKSIEITPQVREALGLDDNVKALSPNDLMSAILKAPVDLLWNGGIGTYVKAASEQHSDVGDRANNALRVNGGELRCKVVGEGGNLGMTQLGRIEAAQAGVLLNTDFIDNSAGVDTSDHEVNIKILLNDVVRAKKLTVEQRNKLLASMTDEVAELVLNDNYRQNQALSLMERMAVKRLGSKQHFIRTLEQQGLLDRQIEFLPSDAELSQRKARGQGLTRPELSVLLSYSKLVAFAQLLESDIPEDPYLSKELQRYFPTPLQKKYADAMERHRLKREIIATAVTNQTINRMGATFLMRMQEDTGRSIAEVAKAYTISRETLDARALWAQIDALDGKVPESVQIDALEVIWKLQRSFVRWLLSRPGAMPGITEAVNRYQGPFNDIRVASGVLPDSQRPTYEALVAEWKEKGLPSALAQQLAELHFLEPAFDIIELARTRKLKPVDVSKVHFRLGDALQLPWLFEQVDALEVNGRWHAVARGVLRDELAANHRNLAGQVLGTKGSSAEAKVAAWMGRDDNSLRFTLAMLAELAEQKTLDYPTVSVAVQRLGQLAAHGA
>NC_010943.1|WP_044570580.1|3209212_3209869_+|TetR/AcrR-family-transcriptional-regulator
MNPAYLPVALDARDERVFDAVRELLAQQGMQMSMEAVAQHAGCSKQTLYSRYGSKQELLRRVMQRHVGHATGAMVRALRTDDLRASLLQFATDFLEHFNQPHVGQACRLIAADAAQFPEEARTLYRHGAGALTLHLAEWIETVCMRGQLQHDDPHFMAELLLSMIAGQDFDKQRFHTPHRDDARLRRRWAEFSVDSFLRAFAPQPSPAPSSNQPRSSS
>NC_010943.1|WP_012480770.1|3209868_3211152_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MTAPLRTLALTCAVAVALAACKKPEQQTPPPPEVGVIDAKPQTLPLQRELVGRLSPFRSADVRARVPGVLLKRVYQEGSQVKQGQTLFLIDPAPLRASLNASEAQLASARATYANAKVAADRARSLAPQQFVSKSDLDNAESAERTALAAVKQAEAAVTSSRISLGYTEVTAPISGVANKQQVTEGALVGQGDVTLLTTVDQLDPLYVNFSLSVDELTQLRAQQAKGALALSGDGKATVNVKLADGSTYSEPGTLDFSSTTVDPATGAVSLRALLPNPQQILLPGAFVSFQANLGERNNAFLVPQQALLRDTTGGYVMVVGADGKVARKNVKTDGAQNGNWLVSDGLAAGDKVIVAGVQKVKEGAPAVAKPWSPGQDANGKPAAGGAAPAGTAPAGTAPAAGKAPADAAKPEQADAAKPAATDSNKQ
>NC_010943.1|WP_012480771.1|3211167_3214341_+|multidrug-efflux-RND-transporter-permease-subunit
MPKFFIEHPVFAWVVAILISLSGVIAILNLGVESYPNIAPPQVTVSATYPGASADTTEKSVTQVIEQQLTGIDHLLYFSSSSSSNGRAQITLTFETGTDPDIAQVQVQNKVSLATPRLPSEVTQQGVVVAKANAGFLMVVALQSDTPTINRDALNDIVGSRVLDQVSRIPGVGSTQQFGSEYAMNIWLNPEKMQGYGLSASQVLAAVRAQNVQFAAGALGSDPSPEGQHFTATVSAEGRFSSPQEFENIILRANADGSRVLLKDIARVAFGANNYGFDTQYNGKPTGAFAIQLLPGANALNVAEAVRAKMDELQPSFPAGVTWFSPYDSTTFVKISIQEVVKTLFEAVFLVFLVMLIFLQNFRATLIPTLVIPVALLGTFLGMWMIGFTINQLTLFAMVLAIGIVVDDAIVVIENVERIMTEEGLAPKPATQKAMTQITGAVVAITVVLAAVFIPSALQGGAAGEIYKQFALTIAISMAFSAFLALGFTPALCATFLKPTHNDNPNIVYRTFNKYYDKISHTYVGHITSAVRHAPRWMILFVVLTALCGFLFTRMPGSFLPEEDQGYALAIVQLPPGSTKGQTNEVFAQMRGILEKQDGYEGMLQVAGFSFVGSGENVGMGFIRLKQWEERKFTAPEFIQNMNGAFYGIKEAQIFVVNLPTVQGLGQFGGFDMWLQDRSGAGYEQLTQARNILLGQAAQKPDHLVGVRPNGLENAPQLQLHVDRVQAQSMGMSVSDVYSTIQLMLAPVYVNDFFYEGRIKRVTMQADGPYRTGQESLKSFYSPSSLTKNADGTNSMIPLNTVVKSEWVSAPPSLSRYNGYSAINIVGSQAPGTSSGEAMQTMESIVNDDLPAGFGYDWSGMSYQEILAGNAATLLLVLSIVVVFLCLAALYESWSIPVAVLLVVPLGVLGALGLSMLRGLPNDLFFKIGLITVIGLAAKNAILIVEFAVEQRAAGKNLRDATIEAARLRFRPILMTSFAFIMGVIPMAISTGAGANSRHAIGTGVIGGMLFATLLGLLMIPVFFVVVRRMLGDKLDEPSKEFMERQRDADAAHRPDR
>NC_010943.1|WP_044570582.1|3214494_3214788_-|hypothetical-protein
MLIYRGAGLLTLLTPIAAVLLILILFPDPAVGRGNTSLSQVLLAFGLGSAINTVLGFVLNRKPRAPGQNAPHHFFFLPMQWPALAIVAACVVIAVLR
>NC_010943.1|WP_005413923.1|3215065_3215983_+|hypothetical-protein
MERAPLRRFSRPALLLGALFAASSVQDAHAAGVLVCDNCRDPRALALYSGTGPTIVVDFQQRRLHGFDVEYDRELRRYRATRAQIPEPINASFNRIMGMLDNNVPTVQFAPRQWAGRGVQYEVHPDDPQYANGIGFPEEHKNLNAYDVVQMATERFRLESAMGKAFTGATTSSRAWNSMATFLSSIGLSFVSKALGIDGAIYRITWRDGSKTTLAIVSSSVDTARYVQGQSKDANGNMIPDGAATSPGLAQHFAGTYNFNSRDDLDRWIDSGRLYGVNMFPGAPPESLQIVCEWNGTDIVCRLPR
>NC_010943.1|WP_005410250.1|3216028_3217177_-|acyl-CoA-dehydrogenase-family-protein
MDFSFTEEQLMLQDVARRIAQEKIAPSAEHHDRTGEFPLDNIRLLGENGLMGIEVPTEYGGAGMDPVAYVLAMVEVAAADAAHSTIMSVNNSLFCNGILTHGTEQQKQTYVRAIAEGEAIGAFALTEPQSGSDATAMRCRAVKQADGTFVINGKKSWITSGPVARYIVLFAMSEPDKGARGITAFLIDTDKAGFGRGKTEPKLGIRASATCEIEFNDYVAQAEDVLGQEGEGFKIAMSVLDAGRIGIASQAIGIARAAYEATLEYVKERKAFGAAIGTFQMTQAKIADMKCKLDAALLLTLRAAWVKGQGKRFSTEAAVAKLTASEAAMWITHQAVQIHGGMGYSKEMPLERYFRDAKITEIYEGTSEIQRLVIARNETGLR
>NC_010943.1|WP_005410251.1|3217330_3218260_+|metalloregulator-ArsR/SmtB-family-transcription-factor
MDLEDWSTRLKVFADATRVRLLALLEQEELTVAELSAITRLAQPRVSTHLARLKEAGLVRDRRAGVSAYYRFDEAQLDPAQRALWHALSNGSDDPLLRQDAERVAAVLAHRASDQNWADSVAGDMERHYSPGRTWEALARTALPLLETGDVLDIASGDGVLAELVAPHAKRYICIDTSARVVAAASERLRRLPNVEVREGDMHALPFKDNSFDLVVLMHALTYASKPAQAVTEGARVLRPGGRLLLCSLARHEHKAAVEAYGHVNLGFSDKELRRFVDKAGLQVSSLETVTREKRPPHFEVISLIAHKP

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Crispr_ID: NC_010943_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010943_10

3647016-3647120

Orphan

Consensus_repeat	Method
CGGTCGTGCCGGCCGCTGGCCGGCAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010943_10

>merge|NC_010943|10|3647016-3647120|CRISPRCasFinder
CGGTCGTGCCGGCCGCTGGCCGGCAATGCCAACCAAGGTTGGCATCCACCAGAGCCGGGCCATGCATGTGAACGCAGGCGGTAGTGCCGGCCGCTGGCCGGCAAT

>NC_010943|10|10|3647016-3647120|CRISPRCasFinder
CGGTCGTGCCGGCCGCTGGCCGGCAAT	GCCAACCAAGGTTGGCATCCACCAGAGCCGGGCCATGCATGTGAACGCAGG
CGGTAGTGCCGGCCGCTGGCCGGCAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_010943.1\|WP_012481000.1\|3648267_3649401_-\|FtsH-protease-activity-modulator-HflK	unknown	unknown	gnl\|CDD\|259802
NC_010943.1\|WP_005410639.1\|3645490_3646783_-\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NC_010943.1\|WP_005414173.1\|3640771_3642898_-\|MCP-four-helix-bundle-domain-containing-protein	unknown	unknown	gnl\|CDD\|185001
NC_010943.1\|WP_005410645.1\|3651098_3651992_-\|DnaJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|182347
NC_010943.1\|WP_044570698.1\|3640391_3640682_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012480992.1\|3639828_3640377_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012481004.1\|3655857_3660765_-\|alpha-2-macroglobulin-family-protein	unknown	unknown	gnl\|CDD\|225248
NC_010943.1\|WP_012481001.1\|3649554_3650550_+\|YhdH/YhfP-family-quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|176183
NC_010943.1\|WP_044570706.1\|3644710_3645373_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012480995.1\|3643130_3644093_+\|murein-L,D-transpeptidase	unknown	unknown	gnl\|CDD\|341130
NC_010943.1\|WP_012480990.1\|3638446_3638938_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237855
NC_010943.1\|WP_012480996.1\|3644097_3644775_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NC_010943.1\|WP_012480989.1\|3636333_3638424_+\|catalase	unknown	unknown	gnl\|CDD\|236886
NC_010943.1\|WP_005414169.1\|3647407_3648271_-\|protease-modulator-HflC	unknown	unknown	gnl\|CDD\|259803
NC_010943.1\|WP_044570710.1\|3653411_3655793_-\|penicillin-binding-protein-1C	unknown	unknown	gnl\|CDD\|227289
NC_010943.1\|WP_005410644.1\|3650638_3651010_+\|twitching-motility-response-regulator-PilH	unknown	unknown	gnl\|CDD\|381093
NC_010943.1\|WP_012481002.1\|3652251_3652734_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239311
NC_010943.1\|WP_012480991.1\|3638947_3639688_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378820
NC_010943.1\|WP_005410647.1\|3652763_3653339_+\|ferritin-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|225104
NC_010943.1\|WP_005414170.1\|3647154_3647340_-\|DUF2065-family-protein	unknown	unknown	gnl\|CDD\|225782

Protein	Function_ID	Function_description	E-value
NC_010943.1\|WP_044570710.1\|3653411_3655793_-\|penicillin-binding-protein-1C	gnl\|CDD\|227289	COG4953, PbpC, Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane].	0
NC_010943.1\|WP_005410639.1\|3645490_3646783_-\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NC_010943.1\|WP_005414173.1\|3640771_3642898_-\|MCP-four-helix-bundle-domain-containing-protein	gnl\|CDD\|185001	PRK15041, PRK15041, methyl-accepting chemotaxis protein.	1.89795e-79
NC_010943.1\|WP_005410645.1\|3651098_3651992_-\|DnaJ-domain-containing-protein	gnl\|CDD\|182347	PRK10266, PRK10266, curved DNA-binding protein.	1.98574e-74
NC_010943.1\|WP_012481000.1\|3648267_3649401_-\|FtsH-protease-activity-modulator-HflK	gnl\|CDD\|259802	cd03404, SPFH_HflK, High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model characterizes proteins similar to prokaryotic HflK (High frequency of lysogenization K). Although many members of the SPFH (or band 7) superfamily are lipid raft associated, prokaryote plasma membranes lack cholesterol and are unlikely to have lipid raft domains. Individual proteins of this SPFH domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Escherichia coli HflK is an integral membrane protein which may localize to the plasma membrane. HflK associates with another SPFH superfamily member (HflC) to form an HflKC complex. HflKC interacts with FtsH in a large complex termed the FtsH holo-enzyme. FtsH is an AAA ATP-dependent protease which exerts progressive proteolysis against membrane-embedded and soluble substrate proteins. HflKC can modulate the activity of FtsH. HflKC plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection.	1.10085e-116
NC_010943.1\|WP_012481001.1\|3649554_3650550_+\|YhdH/YhfP-family-quinone-oxidoreductase	gnl\|CDD\|176183	cd05280, MDR_yhdh_yhfp, Yhdh and yhfp-like putative quinone oxidoreductases. Yhdh and yhfp-like putative quinone oxidoreductases (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.80982e-163
NC_010943.1\|WP_012480995.1\|3643130_3644093_+\|murein-L,D-transpeptidase	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	8.55617e-27
NC_010943.1\|WP_012481004.1\|3655857_3660765_-\|alpha-2-macroglobulin-family-protein	gnl\|CDD\|225248	COG2373, COG2373, Large extracellular alpha-helical protein [General function prediction only].	0
NC_010943.1\|WP_012480990.1\|3638446_3638938_+\|hypothetical-protein	gnl\|CDD\|237855	PRK14900, valS, valyl-tRNA synthetase; Provisional.	7.88881e-16
NC_010943.1\|WP_012480996.1\|3644097_3644775_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	7.91858e-26
NC_010943.1\|WP_012480989.1\|3636333_3638424_+\|catalase	gnl\|CDD\|236886	PRK11249, katE, hydroperoxidase II; Provisional.	0
NC_010943.1\|WP_005414169.1\|3647407_3648271_-\|protease-modulator-HflC	gnl\|CDD\|259803	cd03405, SPFH_HflC, High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model characterizes proteins similar to prokaryotic HflC (High frequency of lysogenization C). Although many members of the SPFH (or band 7) superfamily are lipid raft associated, prokaryote plasma membranes lack cholesterol and are unlikely to have lipid raft domains. Individual proteins of this SPFH domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Escherichia coli HflC is an integral membrane protein which may localize to the plasma membrane. HflC associates with another SPFH superfamily member (HflK) to form an HflKC complex. HflKC interacts with FtsH in a large complex termed the FtsH holo-enzyme. FtsH is an AAA ATP-dependent protease which exerts progressive proteolysis against membrane-embedded and soluble substrate proteins. HflKC can modulate the activity of FtsH. HflKC plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection.	3.90151e-107
NC_010943.1\|WP_005410644.1\|3650638_3651010_+\|twitching-motility-response-regulator-PilH	gnl\|CDD\|381093	cd17538, REC_D1_PleD-like, first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains. PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.3106e-35
NC_010943.1\|WP_012481002.1\|3652251_3652734_+\|peroxiredoxin	gnl\|CDD\|239311	cd03013, PRX5_like, Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 suggests that it may have an important antioxidant role in organelles that are major sources of reactive oxygen species (ROS), as well as a role in the control of signal transduction. PRX5 has been shown to reduce hydrogen peroxide, alkyl hydroperoxides and peroxynitrite. As with all other PRXs, the N-terminal peroxidatic cysteine of PRX5 is oxidized into a sulfenic acid intermediate upon reaction with peroxides. Human PRX5 is able to resolve this intermediate by forming an intramolecular disulfide bond with its C-terminal cysteine (the resolving cysteine), which can then be reduced by TRX, just like an atypical 2-cys PRX. This resolving cysteine, however, is not conserved in other members of the subfamily. In such cases, it is assumed that the oxidized cysteine is directly resolved by an external small-molecule or protein reductant, typical of a 1-cys PRX. In the case of the H. influenza PRX5 hybrid, the resolving glutaredoxin domain is on the same protein chain as PRX. PRX5 homodimers show an A-type interface, similar to atypical 2-cys PRXs.	1.64307e-77
NC_010943.1\|WP_012480991.1\|3638947_3639688_-\|alpha/beta-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	1.41446e-07
NC_010943.1\|WP_005410647.1\|3652763_3653339_+\|ferritin-like-domain-containing-protein	gnl\|CDD\|225104	COG2193, Bfr, Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism].	2.09173e-34
NC_010943.1\|WP_005414170.1\|3647154_3647340_-\|DUF2065-family-protein	gnl\|CDD\|225782	COG3242, COG3242, Uncharacterized protein conserved in bacteria [Function unknown].	6.77277e-12

>NC_010943.1|WP_005410639.1|3645490_3646783_-|adenylosuccinate-synthase
MGQSVVVLGAQWGDEGKGKIVDLLTEEIGAVVRFQGGHNAGHTLVINGKKTVLHLIPSGILRDDALCLIGNGVVISPAALQKEIAELEASGVEVRSRLKISPAAPLIMPYHIALDQARERAAGGKAIGTTGRGIGPAYEDKVARRGIRIADLHYPKQLEELLRTALDYHNFVLTKYLNTDAVDFQKTFDEALAFGEYVQPMKSDVAGILHDLRKQGKRVLFEGAQGALLDIDHGTYPYVTSSNTTVGGALAGSGVGADSIDYVLGIAKAYATRVGGGPFPTELDDEVGQGIRDRGAEYGASTGRPRRCGWMDIVALKRAVAINGISGLCITKLDVLDGMEKLKVCIAYEYNGKRTEYAPLDAQGWEECTPVYLEFPGWSENTHGITNWDDLPPAARAYLRSLEELAGCPISIVSTGPDRDHTMVLQDPFA
>NC_010943.1|WP_044570706.1|3644710_3645373_-|hypothetical-protein
MKGETVVRITLWVLWSLWGIACLVLVLGAAANTLASRTQTVPLVLSPGATAQITVYRLVDDQLRLRLRYAADGTEADPEVLLRIETPTDHGDFRAGERSGVAGQGINRGLASVESSGLMASYFGYGRGDALPRGRSWLRVTVLEVDPALADRAASVELQPPLDLLKLTDLDYVWLWPFFFWKVAALLLLIPGAALAVFTFTLRRWQHRASKQADSAVGTD
>NC_010943.1|WP_012480996.1|3644097_3644775_+|M23-family-metallopeptidase
MRLSQLIVLGVLLGLGAGWWLRRDAGEPVAASLPEAQPAAPVAPAKGSVAPLGTAPAPAATAPSAARTADAPSGLLLPVQGVLASQLRDTFTDARSEGRVHDAIDIMADAGTPVLAVADGTVEKLFDSERGGLTIYQFEPSGRWCYYYAHLQRYADGLAEKQVIKRGDVIGYVGSTGNASAEAPHLHFEVHVLGPEKQWWKGESINPYPLLNPPASKPGAASAAR
>NC_010943.1|WP_012480995.1|3643130_3644093_+|murein-L,D-transpeptidase
MPLPVYRSTLLALSLLASPAFAQAPAPGLPAPIAEKAGPDTAARSALHAQVLLDRANFSPGQIDGEVGSNQRRAVSGFQAAHGLTVTGELDDATWQALQADKVTPLASYTLTSEDVAGPFQAVPKGPAAQAKLKSLGFNNVEESLGERFHASPELLKLLNPGVDLSKAGNRIQVPNIAPSPLPKAAKVVVDKSDSSLQLLDAQGKVIAQVPVSSGSQHDPLPIGEWKILGVYRDPPFHYNPKLFWDARKGEKKATLPPGPNNPVGRVWIDLSKPHYGLHGTPEPGHVGKTESHGCVRMTNWDALRVADAVDTSVPVVMQE
>NC_010943.1|WP_005414173.1|3640771_3642898_-|MCP-four-helix-bundle-domain-containing-protein
MNYLRNVRVAWRLGLGFGLLLLLVAAVVATGATASVVQKRAMQQVVDVSVAKVRLLSQMLDANNQMMVVRREMLIRQGDDRGHDEQRIADLVKRYEASWTAYQALPSDAEGKAIAETIAAKRAIARPLNKQTSELMEQGDYPGAVALTLGPVQEAANGWNKALSDGVDFEEKESREAAAEAIRLGERSLLQLLVLGGVALLVGIAASVMIGRSLTGPLARAVNLAERLSKGQLDQEFRLGGRDELTQLGEAMASVRQSVQAAIGAQLQMAEQHEAGAIRYRMDASAFPGDFGRMVQATNSLVESHVQVELLMAEVMQRYAIGDLSRDLPDYPGEKGTLTRTLAAVKQSLMAINAQIDELARAARAGDFSMRGDAAAFQFQFKAMVEHLNGMMASSQASIADVSDVLRAISHGDLTARMDGEYDGVFARMRDDANTTTAQLTGIVRGIQVAADSINNAAQELAAGNNDLSRRTEQQAANLEEAAASMEELTSTVRQNAELARQADSEAHAAGAAVRETEQAMAQMASVMGEIDQSSARISEISTVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRTLAQRAGVAAKEIKELIEDAAAKVKSGLAVTVESEAAIARVAQASSRTTQLMSDIAAASKEQAAGIEQVNQVVVQMDQVTQQNAALVEEATAASRALEEQAHALTTSVAVFKVEQGARMPIVPAQAA
>NC_010943.1|WP_044570698.1|3640391_3640682_+|hypothetical-protein
MKMRRLLSWTGLALCVVYLLLTAWLVHGAQSDADPKGAYILMSLPITLQSAALDAIGAGSLLYGKPWSTAYAVLVPPTLLLLYAAGWLIERAAGGR
>NC_010943.1|WP_012480992.1|3639828_3640377_+|hypothetical-protein
MRWTYALAMMAMMAMMLPLNSSANDGWINGAGKAMPETDAMKSSGGFAASLLVTSDADWQAKWETPPETTPGFTQADEVHPGGELFLLTFLSNPQLDENRVPKVHCDLRMLRPDGSTSIDERDVPCCTAALPGPPTLLYMTNLHLKFVAEASDPKGTWTAQVVVRDLLRNVSLPLQAHFDVR
>NC_010943.1|WP_012480991.1|3638947_3639688_-|alpha/beta-hydrolase
MGIGSEEKPGCDSASPTPQHVLILPGLDGSGRLSIPFLSALQAHGLTTQAITLPAQGGQDHATLAQRLWSQLPGHPFILLAESFSGPLAVELATRQPAGLRGLVLAATFACRPVPLPAASAALLTSAWPLPPVALLARLLLGRWRTREHLSMLRDALARIPAATLRQRAAATLRVDVRALLPAIDVPTLCLHACHDRLLWPPSVAELQALLPDARHVSLEGPHLLLQARADAAAAEVAAWMRTLSP
>NC_010943.1|WP_012480990.1|3638446_3638938_+|hypothetical-protein
MPRGDKSAYSDKQKRQAEHIEESERERGASEGTAERIAWATVNKQDGGGKRSGSARKGTKKATSKKAAKKAPARKSGTKKATTKTTAAKKAPAKKTTARKAAAKKAPARKTATKKTAKKTAAKKAGTAASRSAAAKKAAKTRAAKKTVRKVAAKKAARTRARG
>NC_010943.1|WP_012480989.1|3636333_3638424_+|catalase
MAASKPTGKRATTHAENHHRGNGDELHQLAGGSHPAMTTDQGIPVADNQNSLRQGPRGPTLLEDFILREKITHFDHERIPERIVHARGSAAHGYFELTRSLKAHTRARILTEVGVKTPVFTRFSTVAGGAGSVDTPRDVRGFAVKFYTREGNWDLVGNNIPVFFIQDAMKFPDLVHAVKMEPDRAFPQAASAHDTFWDFISLMPESMHMIMWAMSDRAIPRSLRMIEGFGVHSFRLLNEAGESTFVKFHWRPKLGIQSTVWDEALKLQSADNDFHRRDLFEAIQRGDFPEWELAVQLFTEEDADAFPFDHLDPTKIIPESLVPLQVIGRMVLDRWPDNFFAETEQVAFCPANVPPGIDFSNDPLLQGRLFSYLDTQLLRLGGPNFHQIPVNAPKCPFANHQRDGHMQMQVPKGRVAYDPSSLQEDTPRETPAGFRSHASADDGRKGRTRAESFADHYSQARMFFRSLEKPEQAHLASALVFELSKVETLKVRVRTVSHLRNIDDSLAQRVADGLALPALPDPAPTATPVRDMPPAPEVRVIGRNKPTLQGRCIGILFDEGSDARIIASLSKAARKAGADVKLVAPRVGGATLSDGALQAADGQLAGTPSAVFDAVAVVLSPEAAKALSKESAAIEFVSQAWAHLKAIASDAGGQTLLKAARVGNDAGIVEAEDAKAFLAAAATRQWAREPKLRLLA
>NC_010943.1|WP_005414170.1|3647154_3647340_-|DUF2065-family-protein
MKDLFAAVCLVAVLEGLFLFVAPFAWKRMAERLLDLPSPALRSFGGLVLLAGLSLLWWVRH
>NC_010943.1|WP_005414169.1|3647407_3648271_-|protease-modulator-HflC
MKSPIWIAVIVAVVLGLLGSVYVVREDQTAMVLNLGKVVRSDIKPGLHFKVPVVETVKVFDRRFQVLDTAPARYFTAEQKDVSVDFFAIGYISNVGDYFRATGGDPRIANARLAPIITDSLRNQINSRTLQQLVSGDRSELIAEQLKGINEAVAGLGMQMIDLRIKQVDLPTDSQVINDVYERMRAQRKQEAAKLRAEGEEQSLTIRAQADRDSTVLIAEAERDAQRLRGEGDAEAARIYGKAGSADPSFYAFYRSLEAYRGSMTDGNGVIVLDKNDPFLQYLKNDR
>NC_010943.1|WP_012481000.1|3648267_3649401_-|FtsH-protease-activity-modulator-HflK
MAWNTPGGNKGGQGPEDNRRGPFGSRGGGNGGGWGGLPGPLKDLFDGGIVRWVVAAVVLLVLFSSFQLIGEQQRGVVLRFGQFSRILQPGPNFKLPWPIESVTKVNATEIKTFSIQVPVLTRDENIVNVSLNVQYRIDDPQQYLFGTVDANQVLEQSAQSAVREEVGRADLNAVLNNRGPLAVAAEERLQALLKAFKTGLTVTGLTLQDARPPEEVKPAFDEVNGAQQVKERLINEAQAYAAKVVPEARGQASRARTTAEGYKQAVVSKAEGDAQRFSLLQAQYKDAPEVTRKRLWLETVQQVLSENRKVIGGDGRQLIYVPMTGDTRPSTSAPAAVANPDVVMPSLPGAATEASRDPGRPVGRPTGRPNGREEGSR
>NC_010943.1|WP_012481001.1|3649554_3650550_+|YhdH/YhfP-family-quinone-oxidoreductase
MAPTTPFTAFRIENDDAGYRSGLVRLGVDDLNPGQVLIRAHWSSVNYKDALAGTGKGKILRRFPLVGGIDVAGTVVASTDPDWREGDAVLATGCGLSETRDGGYSQYVRLESRAVIAQPAGLTPREAMVLGTAGFTAALALLRMQDNRQTPELGPLAVTGASGGVGALALSIFSRAGYSVHAVSGKPDQAGFLRSIGATEVLPRDALADTGALQSARFGGGLDNAGGDMLASLLTQTVPYGSVVSAGLAASPTLDMTVMPFILRGVSLLGVSSANAPRGLREEVWSRLGSDWKPQHLDRICTAEVGLDGLPAVFERMLAGGSLGRTVVRID
>NC_010943.1|WP_005410644.1|3650638_3651010_+|twitching-motility-response-regulator-PilH
MARILIVDDSPSQLLGIQRIVEKLGHQILTATDGAAGVETAKAELPDLVLMDVVMPNLNGFQATRTLARDEATRHIPVILVTTKDQDTDRMWGMRQGAKAYITKPFSEDELSEVLERVFAGQG
>NC_010943.1|WP_005410645.1|3651098_3651992_-|DnaJ-domain-containing-protein
MEFKDYYATLGVEPSAGEAEIKTAYRRLARKYHPDVSKEAGAEDKFKAVNEAYEALRDPEKRAAYDQLRAQGYRPGEEFNVPPNYGGAGGFNFEEVFGGGGPNGGFSDFFESLFARQRGGAGAGAGPGFSSQGHAPNRDTRAKLSVPLEAAYSGDSLRITVNGKQLDVRVPKGIRPGQVIRLAGQGNHGGNLLLEVEYAAHPQFEVDGRNILYTLPLTPWQAALGTSISVPTLGGAVELKIPADSDAGRKLRLRGRGLPGNPDGDQIVEIEIVAPAATDEAQKKAYRNLAKAFGETI
>NC_010943.1|WP_012481002.1|3652251_3652734_+|peroxiredoxin
MTIHVGDRIPEVTLKRIREGIETLDTHSLFDARKVVLFAVPGAFTPTCSARHLPGYVEKFEAFRQRGINVYCMAVNDPFVMKAWAADQSVPDGLLMLSDGNAELTRALGLELDASASGMGIRSRRFALYVDDGVVREAWVEQPGQFEVSSAEYVLEHLPT
>NC_010943.1|WP_005410647.1|3652763_3653339_+|ferritin-like-domain-containing-protein
MSSKPAKASKPAANVPGISDRATLRERARRNLEDGAITDSYSADREVVIKLLNDALATEYVCVLRYYRHYFMAKGMLADAVKAEFLEHAQQEQAHAGKLAERIVQLGGEPDLNPDTLTARSHAEYKEGSDLRDMVRENLVAERIAIDSYREMINFIGDRDTTTKRILEEILAQEEEHADEFADLLDGWIGE
>NC_010943.1|WP_044570710.1|3653411_3655793_-|penicillin-binding-protein-1C
MTNTMTTRRAALRRRLQPLWPWLRWGTAATLALLLVLDFAFPPPLPKQRDTSTLVVAADGTPLRAFADAEGVWRYPASTDSVSPLYLQALLTYEDRWFWRHPGINPLAILRASGQLLRGGRIVSGGSTLTMQVARILDPHTRTPWGKLKQMLRAVQLEVHLSKQQILALYLERAPYGGTIEGVEAASWAYLGKPAAQLSHAEAALLAVLPQAPSRLRPDRHPEAAQKARDKVLSRMAELGAWTAEEVEDARIENVVARSLRPPLHAALLAQRLHSAHPGQARIQSSIDIGLQRTLEERVASYFSTLPERTSAALLVVDNQTLKARAYVGTLAFGDRQRLGHVDMVQAWRSPGSTLKPFLYAMALDDGLIHSESLLVDAPQSFGSYRPGNFDMAFNGPIGASSALRLSLNVPSVDLLQRVGPARFAARLSHSGIQLRFPPGSTPNLSLILGGTGARLEDLVGAFAALNRNGIAGRVRYTDDEPMIERRLASPGASWIVREMLESNPRPGYSVGTFDVGGRPRVAWKTGTSYGYRDAWAIGSTRHYTVGVWVGRPDGTPLPGQYGAVTALPLMFEVVDSLPRQRGDSAAAPMPASVSQEDICWPTGERAEGLPAALCQRLMPAYLLEGAAPPTFPEREARRWQPGRQRYLADARTGLRVSADCRLPHEEVAREIARWPALLSPWLSKATREASQLPALSPDCRDDGREASVALHIDGLNDGATLARAPNSEHGVRLQLRALGSEQAVDWLLDGRWIAQTRGAQLMQREFAEPGAHTLTALAADGAWTQVRFNVLR
>NC_010943.1|WP_012481004.1|3655857_3660765_-|alpha-2-macroglobulin-family-protein
MSGPARRKRWGWAAAVLAGGLLLGLAGCRNDSGQLPKASGEAITTKAEQVKEFTLLRAYPDQKNDGLSLALEFSRPLVGTQDFDKLVRFEEKVGTDDSSWTLSDDGLTLRYPFVEAGKEFSLVVSPDLLAADGSRLGKELKQKVFSGELKPVVGFASQGSVLPAKDSRGLPVVSVNVPEVDVEFLRVREKDLPTFFSQYQRGGRRGSWELSSDYERSPINKLAEPVYVNRFILGGKKNERVLTYLPTQDIKELQEPGLYFALLKRTGDYEGEFDTAFFSVSDIGLHTRAYKDKLFVHTAGLKDGVPLKGIDLRVLDAKGEVVLKGSTDGNGNALLNYTLDATHVLVASTGKDTSFLPFNQPALDLSEFAVAGRDNAWFDVYAWSGRDLYRPGETVRLSALLRDNDGKPVKAQPVFLRLKQPDGKTFRETRLQPGDQGYINFEQVIPAEAPTGRWQVEFRTDPASKEAIQGMTLRIEEFLPERMKLDLDSAQKTLKPGEDLRLQANGAYLYGAPADGNRFTARMAVAAEQKPVEGLPGYFFGDPTLQLPREAKDVIDTTLPGNGQLREDVALPEEAAKAKAPIAVVLSGSLYETGGRTVTRTLKRVMWPANALVGVRPLFNPEDGADSNGNARFELMRVDAAGTPQPAKGLKITLVRELRDYHWTFNDNRWDYDFTRRFENKETRTVDAGSSAVAFDFPVEWGEYRVDVFDPSTGLTSRYPFRAGWSWGDDNRGLDARPDKIKLGLDKTGYKAGDTLEVTVTPPHAGKGILMVETDRMLYVQDIDAKPGSTFKIPVTADWERHDVYITALVFRGGSAPSKITPARAVGVVHVPMDRKGRTVAVGLAAPKQMRPEQDLPVTVSAPQLAGKMAHVTVSAVDVGILNITRFPVPDAGAHFFAQRRLGIDAYDIYSRVIESFDGGAGKLKFGGDMALQALPQAKRPTARVQTVDLFSGPVQLDAKGIARIRLKVPDFNGTLRVSALVYSDDQYGKRDVETVVRAPILAEASMPRVLAPGDRSTVTLDVQNFTGKPGQFNVKVESEGPLNLGEGSRSVQLNADAKTTLSFPLSAREGHSVAKVRVRVDGNGFKADRRYDLPVRAAWPQVLRSQVRTLDPLAAVSLDNSLTDGLMAESVNARLLVSPLPPIPFASALQGALNYPYGCAEQTTSKGYAALILDQATSSMLGADGLDAKTRRERMEGAFGRLASMQVANGNFSMWGDDGYVNPWLTPYITEFLLDAKDAGFAVPDNVLQKALNRLSEDLLSGGNQFYGQDDREKLKFANQAYSGYVLARVNRAPLGTLRTLYDNERSKAVGGLSLVHLGVALSLQGDAKRGQAALAAAFAKSSSERPSYFGDYGSAIRDDALMIALTHENKLAKPAWDARAVDLGRGLDARRNAGWMWLSTQEQVAIARLGKALAANQKALVAGELVIGGNTEAIGERKLFGRNFSANELASGVRFTPQGQPPMFASIDVAGIPRSAPAPDNSVLGVERSYYGTDGKPWSPRPLKEGEALIVRVTVTADTTMPDALLTDLLPAGLEIENFNLGDAKQWADVVVDGITISDRGEAADTKHEEFRDDRYVAALKLSRGSKANVFYLVRAVTPGTYSVPPPLVEDMYRPQLRGVGRSNPTTITVVQP

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Crispr_ID: NC_010943_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010943_11

3819103-3819216

Orphan

Consensus_repeat	Method
TTGGGTAGGTGCGGACCGTTGGTCCGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010943_11

>merge|NC_010943|11|3819103-3819216|CRISPRCasFinder
TTGGGTAGGTGCGGACCGTTGGTCCGCACGACACGGCAGTGCCGGCCGCTGGCCGGCAACTTCGTGATCCGGGTGCGGATCTGCTTTGGGTGGGTGCGGACCGTTGGTCCGCAC

>NC_010943|11|11|3819103-3819216|CRISPRCasFinder
TTGGGTAGGTGCGGACCGTTGGTCCGCAC	GACACGGCAGTGCCGGCCGCTGGCCGGCAACTTCGTGATCCGGGTGCGGATCTGCT
TTGGGTGGGTGCGGACCGTTGGTCCGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_010943.1\|WP_005414292.1\|3810218_3810929_+\|glutathione-S-transferase	unknown	unknown	gnl\|CDD\|373097
NC_010943.1\|WP_012481082.1\|3811008_3812613_-\|membrane-protein	unknown	unknown	gnl\|CDD\|225161
NC_010943.1\|WP_044570773.1\|3827214_3828417_+\|lipase	unknown	unknown	gnl\|CDD\|367570
NC_010943.1\|WP_044570768.1\|3813222_3814941_-\|pyruvate-oxidase	unknown	unknown	gnl\|CDD\|181661
NC_010943.1\|WP_012481080.1\|3806459_3809045_-\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529
NC_010943.1\|WP_044571436.1\|3815070_3815928_-\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|377965
NC_010943.1\|WP_012481092.1\|3824263_3825034_-\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|182677
NC_010943.1\|WP_012481089.1\|3821889_3823254_+\|alpha,alpha-trehalose-phosphate-synthase-(UDP-forming)	unknown	unknown	gnl\|CDD\|274112
NC_010943.1\|WP_012481090.1\|3823324_3823762_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NC_010943.1\|WP_044571438.1\|3823736_3824279_-\|DUF4166-domain-containing-protein	unknown	unknown	gnl\|CDD\|379359
NC_010943.1\|WP_012481079.1\|3805586_3806387_+\|MipA/OmpV-family-protein	unknown	unknown	gnl\|CDD\|226236
NC_010943.1\|WP_044570765.1\|3809226_3810048_-\|DUF3014-domain-containing-protein	unknown	unknown	gnl\|CDD\|378600
NC_010943.1\|WP_012481085.1\|3815964_3816447_-\|DUF3574-domain-containing-protein	unknown	unknown	gnl\|CDD\|371896
NC_010943.1\|WP_012481088.1\|3820111_3821893_+\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|225922
NC_010943.1\|WP_012481087.1\|3819311_3820070_+\|trehalose-phosphatase	unknown	unknown	gnl\|CDD\|319767
NC_010943.1\|WP_005410789.1\|3825033_3826023_-\|23S-rRNA-pseudouridine(1911/1915/1917)-synthase-RluD	unknown	unknown	gnl\|CDD\|183020
NC_010943.1\|WP_012481078.1\|3804156_3805446_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|236724
NC_010943.1\|WP_012481095.1\|3828904_3830539_-\|NAD+-synthase	unknown	unknown	gnl\|CDD\|237577
NC_010943.1\|WP_012481093.1\|3826136_3827024_+\|outer-membrane-protein-assembly-factor-BamD	unknown	unknown	gnl\|CDD\|274513
NC_010943.1\|WP_012481086.1\|3816661_3819097_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657

Protein	Function_ID	Function_description	E-value
NC_010943.1\|WP_005414292.1\|3810218_3810929_+\|glutathione-S-transferase	gnl\|CDD\|373097	pfam14497, GST_C_3, Glutathione S-transferase, C-terminal domain. This domain is closely related to pfam00043.	2.34683e-30
NC_010943.1\|WP_012481082.1\|3811008_3812613_-\|membrane-protein	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	8.55203e-07
NC_010943.1\|WP_044570773.1\|3827214_3828417_+\|lipase	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	1.14845e-06
NC_010943.1\|WP_044570768.1\|3813222_3814941_-\|pyruvate-oxidase	gnl\|CDD\|181661	PRK09124, PRK09124, ubiquinone-dependent pyruvate dehydrogenase.	0
NC_010943.1\|WP_012481080.1\|3806459_3809045_-\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NC_010943.1\|WP_044571436.1\|3815070_3815928_-\|SH3-domain-containing-protein	gnl\|CDD\|377965	pfam08239, SH3_3, Bacterial SH3 domain.	0.00366959
NC_010943.1\|WP_012481092.1\|3824263_3825034_-\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|182677	PRK10723, PRK10723, polyphenol oxidase.	4.62936e-86
NC_010943.1\|WP_012481089.1\|3821889_3823254_+\|alpha,alpha-trehalose-phosphate-synthase-(UDP-forming)	gnl\|CDD\|274112	TIGR02400, Alphaalpha-trehalose-phosphate_synthase, alpha,alpha-trehalose-phosphate synthase [UDP-forming]. This enzyme catalyzes the key, penultimate step in biosynthesis of trehalose, a compatible solute made as an osmoprotectant in some species in all three domains of life. The gene symbol OtsA stands for osmotically regulated trehalose synthesis A. Trehalose helps protect against both osmotic and thermal stresses, and is made from two glucose subunits. This model excludes glucosylglycerol-phosphate synthase, an enzyme of an analogous osmoprotectant system in many cyanobacterial strains. This model does not identify archaeal examples, as they are more divergent than glucosylglycerol-phosphate synthase. Sequences that score in the gray zone between the trusted and noise cutoffs include a number of yeast multidomain proteins in which the N-terminal domain may be functionally equivalent to this family. The gray zone also includes the OtsA of Cornyebacterium glutamicum (and related species), shown to be responsible for synthesis of only trace amounts of trehalose while the majority is synthesized by the TreYZ pathway; the significance of OtsA in this species is unclear (see Wolf, et al., ). [Cellular processes, Adaptations to atypical conditions].	0
NC_010943.1\|WP_012481090.1\|3823324_3823762_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	1.03716e-50
NC_010943.1\|WP_044571438.1\|3823736_3824279_-\|DUF4166-domain-containing-protein	gnl\|CDD\|379359	pfam13761, DUF4166, Domain of unknown function (DUF4166). This domain is often found at the C-terminus of proteins containing pfam03435.	1.07661e-22
NC_010943.1\|WP_012481079.1\|3805586_3806387_+\|MipA/OmpV-family-protein	gnl\|CDD\|226236	COG3713, OmpV, Outer membrane protein V [Cell envelope biogenesis, outer membrane].	2.79682e-39
NC_010943.1\|WP_044570765.1\|3809226_3810048_-\|DUF3014-domain-containing-protein	gnl\|CDD\|378600	pfam11219, DUF3014, Protein of unknown function (DUF3014). This family of proteins with unknown function appears to be restricted to Proteobacteria.	4.38975e-54
NC_010943.1\|WP_012481085.1\|3815964_3816447_-\|DUF3574-domain-containing-protein	gnl\|CDD\|371896	pfam12098, DUF3574, Protein of unknown function (DUF3574). This family of proteins is functionally uncharacterized. This protein is found in bacteria and viruses. Proteins in this family are typically between 144 to 163 amino acids in length. This protein has a conserved TPRF sequence motif.	6.79074e-44
NC_010943.1\|WP_012481088.1\|3820111_3821893_+\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	2.31122e-84
NC_010943.1\|WP_012481087.1\|3819311_3820070_+\|trehalose-phosphatase	gnl\|CDD\|319767	cd01627, HAD_TPP, trehalose-phosphate phosphatase similar to Escherichia coli trehalose-6-phosphate phosphatase OtsB and Saccharomyces cerevisiae trehalose-phosphatase TPS2. Trehalose biosynthesis in bacteria is known through three pathways - OtsAB, TreYZ and TreS. The OtsAB pathway, also known as the trehalose 6-phosphate synthase (TSP)/ Trehalose-6-phosphate phosphatase (TPP) pathway, is the most common route known to be involved in the stress response of Escherichia coli. It involves converting glucose-6-phosphate and UDP-glucose to form trehalose-6-phosphate (T6P), catalyzed by TPS, the product of the otsA gene, this step is followed by the dephosphorylation of T6P to yield trehalose and inorganic phosphate, catalyzed by a specific TPP, the product of otsB gene. This OtsAB (or TSP/TPP) pathway, is also the most common route known to be involved in the stress response of yeast In Saccharomyces cerevisiae, the corresponding enzymes, TPS1p and TPS2p, form a multimeric synthase complex together with additional regulatory subunits encoded by Tsl1 and Tps3. Trehalose is a common disaccharide accumulated by organisms as a reservation of carbohydrate and in response to unfavorable growth conditions. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.07747e-65
NC_010943.1\|WP_005410789.1\|3825033_3826023_-\|23S-rRNA-pseudouridine(1911/1915/1917)-synthase-RluD	gnl\|CDD\|183020	PRK11180, rluD, 23S rRNA pseudouridine(1911/1915/1917) synthase RluD.	2.7602e-148
NC_010943.1\|WP_012481078.1\|3804156_3805446_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|236724	PRK10604, PRK10604, sensor protein RstB; Provisional.	1.25543e-70
NC_010943.1\|WP_012481095.1\|3828904_3830539_-\|NAD+-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NC_010943.1\|WP_012481093.1\|3826136_3827024_+\|outer-membrane-protein-assembly-factor-BamD	gnl\|CDD\|274513	TIGR03302, OM_YfiO, outer membrane assembly lipoprotein YfiO. Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking].	2.41264e-90
NC_010943.1\|WP_012481086.1\|3816661_3819097_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	6.32871e-63

>NC_010943.1|WP_012481086.1|3816661_3819097_+|TonB-dependent-receptor
MSVRLPASPLGLAIALALSSAAVPALAQDATNLDTVIVTGTRAADRTVLESTSPVDVLTAEDIRKAGVVNGELGSALQALLPSFNFPRQSNSGGADHVRAAQLRGLSPDQVLVLVNGKRRHHTALVNTDSKIGKGTTPVDFNSIPVSAIKRIEVLRDGAGALYGSDAVAGVINVILDNGGDGGEIEASYGANHTDLKPIGRTLTDGQTGNISAKVGTSLGEDGGFLRVGLEYKHRNGTNRAGFDQIPPWDQTPGNLALQGKRNYVLGDGKSKDINLWLNTEIPVGQTSTFYAFGTFNQRDTEGANYFRYPDGEANWKQVYPNGYRPISEGENRDVQAVAGVRGQWGEWSYDGSLDYGQNDFTYRLRDSLNASLGPTSPTRFKTADYEYAQTVGNLDLSRVFTQSDSISHTLGLGVEARHERYQTRPGDPASYAAGPYTDRPTGSQAGGGLTPQDAATLSRDVASAYASLSSQFGEKFSTDLAARYEHNDDFGGELTGKLGLRYEFTPAFALRGAISNNFRAPSLAQIGYESTSTGYNAGGQLVQGRLLSVNNPIARGLGAQNLKPEKSINTSLGFTSKIGEHFDLSLDFFQIDIDDRIALSESITGDALTDYVAANYGVSGLQSASFFVNAADTRTRGAELVSNWRQSLGDGQLLLTGTYAYTKTTLKNVLATPAQLRALNPDYVLFGIEETNTLTDATPRTRGSFSAAWSNDHWSLSTRVNRYGSATRVFNFGDGYIPRQTYQAEWQLDAEVEYRITPRWSVAIGGQNLTDNYPDRSNSDIHYFGNLPYDVLSPIGSNGAYYYGRVRYTF
>NC_010943.1|WP_012481085.1|3815964_3816447_-|DUF3574-domain-containing-protein
MKHLGLVFAVLLATSGCASLSSQAPSAYATATTAELKGDAARPSAGHGWVRSELYFGVGEEQGAGNRPQADTISEAQWRTFLDKEVTPRFPDGLTVFDAYGQWLFRGDASPNRLRTKVLVVLHEDTQQRRADIEAIRLAWKQQTKHQSVLWSRQPVEVSF
>NC_010943.1|WP_044571436.1|3815070_3815928_-|SH3-domain-containing-protein
MNYRECVLGLVLAGVLAPSAQASGDDGETLRFQVAAHVQAHADPQQDGSIAVQLSPSGKRQTLEGAADADGSSRWALEDVDFDGYPELVARAPVGMVNEAVAVYRFDPASAGFRALQADTHGKDSCGDLMGLSVDAATRTLTSSCRSGPMWYTDQYRFAGAKLHLYRSESVLMLGDTLNAALQWEQTDEQGPLAVWRTYDPAGRVLESAIADGLGAPPDGPLQGQQATVVPARLFLFDRPGASSTKRYLVQGDRVELLDEQDGWVKLRYRNPKQGAVEGWINVND
>NC_010943.1|WP_044570768.1|3813222_3814941_-|pyruvate-oxidase
MSKRVAEIVVDALQQAGVRRCYGIVGDTLNHVTDAMHGSEIAWVHVRHEEVAAFAAGADSLVSGELTACAGSCGPGSLHFINGVFESNRNRAPMVLIASQVVTSELGMEFPQEVDFKAVYASCSVFCEQVHSAEQARRVVTLACQAAISRRGVAVVILPADISQAEVKHDVPFSVHYTQPVLRPSDAELQRIAELLGRGKRIGIYAGAGCQGAHAQLLELARRLQAPIAHTSRAKDFVEPDNPYNMGMTGIFGIESGFHTLMECDTLLLLGADFAWGQFYPDKATIIQVDRDGSHLGRRHPVNLGVVGDIAPTLDALLPMLPPREDSSFLDECIERRDKALKKREQEEQPGEGELIHPQHLTALLSKYASDDALFTADGGSPMVWVLRHIRVNGRRRTLTSLLHGTMANAMPQALGLQKAFPGRQVISLSGDGGLAMLLGDLLTAVQENLPIKVVVFNNGSLNFVELEQKVEGLLDNYTDLKNPDFGRLAEVIGFHGRTVTRSEDLEEAVQDFLSQRGPALLDVHTSRAELVMPPQIEAKQVAGTALYAAKAVLNGRFDDVKHLLVDNFLKK
>NC_010943.1|WP_012481082.1|3811008_3812613_-|membrane-protein
MSAPASAAPRRWFVAGDFNGFFGLVVDNLSILGFIAMALVGIFQFPADVVFGRMFPGTAFGVLVGNLLYTLMARRLAARTGRDGVTAMPLGLDAPTSIGMALLVLGPAFIAFKQQGMDPHAAGIATWQLGMAALVIMGVLKFVLSFFGEAVTRALPRAALLGSIAGIALVLMGLLPLLETLRSPLVGFTTLGLLLYVLIAKGKLPVRGPGVLLAFVFGTVLYYGLGLAGLGAPGFHVPEWVPPQVVLPLPTLGFLDGLPTAMTYLPLLLPFGLLMVVGGINVSESARAAGDDYRTRDILLVEAVATLVAGVCGGVAQTTPYIGQPAYKHMGARSGYTLLTGLFVGIGGMLGIISGLVQWLPLAVLAPIIVYVAIDITTQAFQATPRHHTGAMVFGFLPSVAYLLAIKAPGWIAPDQLPQLLTKLDGHGLPELAVIFTLGNGFIITSMLWISAVAAMVDGRLRRACGFLLVAAVLTLFGLIHSVDPRGGIYLPWELDGLARIISWQFAGAYVALALLLGLLSLQKQPVKPMGENS
>NC_010943.1|WP_005414292.1|3810218_3810929_+|glutathione-S-transferase
MQYALYYWTGIQGRGEFVRLALEDAGADYIDMARVHGDAVMQPFLDGGSEGAQPFAPPFLKAGRQVIAQVAAILDFLGPTLDLVPQAASRRVQALQLQLTIADLVAEVHDTHHPIAASKYYEEQKTEAKARAASLRSERLPKFLGYFEQVLAANGGRHALREHSYVDLSLFQLLSGLDYMFPRRMQALAPTLPLLRALQERVAKRPNIAAYLASERRLPFNTNGIFRHYPELDAER
>NC_010943.1|WP_044570765.1|3809226_3810048_-|DUF3014-domain-containing-protein
MQSGKAVWPWVLGVVVIGGAGGWLFRDQLKRLADGVSVPVQSTPASTGAPPQPQAAAQPAPAPPPIRHPLDTEAAADPALPTLADSDAAAWGALSQLFQGEGPLTLLLRDHLIQRLVTQLDNLDKPSVPPTALAARPLPGSLQVEPAEGGERIAASNAARYAPYVQAFTALDPAATATAYKRFYPLIQQAYVDLGRPDGYFNDRLVAVIDHLLDTPELAQSPVVQRDERGRYRFVDPTLQSRSIGQKALLRMDAAQARAVKQQLRAIRSAITR
>NC_010943.1|WP_012481080.1|3806459_3809045_-|ATP-dependent-chaperone-ClpB
MRMDKLTSRFQQALADAQSLAVGRDNSIIEPVHLFSALLDQQGGSTRPLLAQAGVNVPVLRERLTEALDALPKVSGQAGNVSMGNDLGRLLNQTDKLAQQHGDAFIASEWFVLAALDDGGTLGMALRAAGADKTRLQAAIDKLRGGENVQSENAEEQRQALEKYTIDLTARAESGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINDEVPEGLRGKRVLSLDMGALIAGAKFRGEFEERLKGVLNDLAKNEGQIILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCIGATTLDEYRKYIEKDAALERRFQKVFVGEPSVEDTIAILRGLKEKYAVHHGVEITDPAIVAAATLSNRYITDRQLPDKAIDLMDEAASRLRMEIDSKPEELDRLERRVIQLKIQREMLKKEKDEASRQRLADLENDIDGLEREFSDLNEIWKSEKAALQGATKIKEQVEQAKLELEAAQRRQDFAKMSEIQYGLLPQLEKQLAAAQEAEHKDFKLVQDRVTDEEIAEVVSRWTGIPVNKMLEGERDKLLRMEEVLHNRVVGQEEAIKVVSDAVRRSRAGLSDPNRPAGSFLFLGPTGVGKTELCKSLAEFLFDSADAMIRIDMSEFMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRRPYSLILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVIVMTSNLGSHQIQDMSADDSPEAYTQMKAAVMGVVQAHFRPEFINRLDDIVVFHPLDKQQIKQIARIQMRGLEKRLAERGLKLAVSDAAFDLLGNVGFDPVYGARPLKRAIQSQLENPLAQQILSGAFVNGDTIEVGNDGGRLVFAKA
>NC_010943.1|WP_012481079.1|3805586_3806387_+|MipA/OmpV-family-protein
MSQLRRSPALLCLALLPLFAAPIAHAKDDHWTFEVAAGGGVAPRYSGSEEYRATPSLSFDVTSPGGWFLGTSGIGWGTSIGEHTRVRAYVGASGIRKEKDSLLGGSDFLRGMGDIDARPLVGVSAGYTLGEAVLSGSWQFTRKDEDKAENGLATQQIHLNLSMPLFDLAGGVISGSVSTDYGNRGYMQTWYGVSPEQAARTGFAEHKPKAGLVSAGVGLKWSHRVGRNGNWYISAEGTRLLGDAADSPIVQKANQFGLMSGYTHRF
>NC_010943.1|WP_012481078.1|3804156_3805446_+|two-component-sensor-histidine-kinase
MKRLFLWLWFITGACFLVSVFFLNHILDGIYTPVQDRVFVQQVRGQVYALRSGLAGLDADQQRERLKQWQPHYGIALTLLDKPPALDAQEQVAVKADGFIVRDQYQQVLLPIGGSDGRWLHLRLPGAVQMTTYMTIAAYLSILLLVGASLYAWVRLLWRDLEALRRHADRIGSGDLQARAQVSPRSQIRVIVDHSNRMAARVAELVQRQRDLTHAISHELRTPIARVAFGLDLMQDSDDRERRERLARGLHGDLAELNRLVSELLAYERLEHPSEGEPMQRIEANDWLQACLADARRDAERAGVILRVQPSALPRVDAEPRLLQLALSNLVGNALRHARSQVEVSLVGVSGRACLRVDDDGPGIAEADREKVMRPFTRLDDSRSRDTGGFGLGLAIVSRIAVRHGGELRISRATLGGARMEMHWPLAAS
>NC_010943.1|WP_012481087.1|3819311_3820070_+|trehalose-phosphatase
MAEPLPLRPPPPLLDDACALFLDVDGTLIEFAARPDAVQLLPDVREAIGRISDRLEGAVALVSGRPLEQLDQLFAPLQLPAAGLHGHELRGEDGRVLRDEHDDDTAEWLHALHQQAMRFAHGHPGVLVEDKGVGLALHWRGAPRAASDVRAFADRHVRGRTSYRLQPGDHVVEFVPVGTDKGRAVRRMMQYLPFRGRLPVFLGDDLTDEFGFDAANGQHGWSVLVGEREPSAAVFALPDIRSVHAWLRENAY
>NC_010943.1|WP_012481088.1|3820111_3821893_+|glycoside-hydrolase-family-15-protein
MTQPDLDLGVVGNGSFGALVDKHARVVWSCLPTFDGDPTFCALLGPNQQTGGDFAIELEDFASSEQEYLTNTAILRTVLRDTQGGALEILDFAPRWRQNDRFYRPVSLIRQVRPLAGSPRITVRARPLADWGARVPESTWGSNHVRWILPEHVLRLTTDVPVRFVRDGLPFVLNHPIHLILGVDESLNRSISGYVQEAFQRTRDYWREWVRYLSIPLEWQDAVIRSAITLKLCQYEDSGAIIAAMTTSIPEAPGSVRNWDYRYCWLRDAAFVVRALNRLGATRTMEQFLGYIFNLATTDGTLQPLYGIGFEAKLDEDEVPSLSGYRGMGPVRRGNLAWVQRQHDVYGSVVLASTQLFFDRRLQDPGDAHTFARLEPLGEQAFALHDVPDAGLWEFRGRTEVHTYTSAMCWAACDRLCKIAVRLKRDDRAHYWRERADTIHARIMAESWNEELGHFTDTFGGHRLDASLLLLADIGFIDALDTRFIATVDAIGRDLKHGNSLYRYVAPDDFGEPETSFTICTFWYIDALAAIGRMDEAREMFELLLKQRNHLGLLSEDLAFDSGEAWGNFPQTYSHVGLITAAMRLSRSWQEAS
>NC_010943.1|WP_012481089.1|3821889_3823254_+|alpha,alpha-trehalose-phosphate-synthase-(UDP-forming)
MSRLVVVSNRVAVPGENRAGGLAVGLLAALKERGGLWFGWSGKTVKEGSGMLHRQKDGDIDYVTMDLSKREVDGYYNGFANRTLWPLLHFRLDLVDYDRGTRETYHKVNALFADKLAPLLREDDIVWIHDYHLIPLGALLRERGIGCRIGFFLHIPMPSADLLQAMPDHLRLFSALYAYDLVGFQTQRDADRFQTYLRLFGGGRVLDNGELEAPGGRRFRAAAFPIGIDTELIARQAGTAATKAAVKNLRASLRDRQLAIGVDRLDYSKGLPERFLGFERYLERHPDQRGSLTYLQIAPVSRGDVTEYRQLRSQLEQIAGHINGGHAEPDWTPLRYVNQNFTHATLTGFYRAAAVGLVTPLRDGMNLVAKEYVASQDPEDPGVLVLSLLAGAADELKQALLVNPHDLDGVADAIATAATMSLSRRKERWHAMMDHLRTYDINHWRRSYLDALEG
>NC_010943.1|WP_012481090.1|3823324_3823762_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MKVGSNRSEAAAEAGSAVIVFDGVCALCNRWVRFLLRFDRAGRYRFAAMQGQQGSAMLRAHGLDPQDPMSFLLLDAQGAWTDTDAILRVLTGLGGAWRLIGVLRAVPRGWRDAAYRALARNRYRWFGRHDACHLPAPEQAARFLD
>NC_010943.1|WP_044571438.1|3823736_3824279_-|DUF4166-domain-containing-protein
MDRALTTPLFARVLGPAFATLAAPVQALHAAPLPCRYVGHARIVRGRHWLVPLLAALARLPKDGEALPTEVAFSAHGQGEQWARRFGRWPMVSRLWAHEGCLREQLGAVRFEFDLQAREGGIDWSVRRVWAFGLLPLPRHWFGGVRCREAWQGERYTFLVDVTLPWAGALIRYEGWLEPQ
>NC_010943.1|WP_012481092.1|3824263_3825034_-|peptidoglycan-editing-factor-PgeF
MAAALPVLQADWLAPPGVHALTTRRHGAGISPAPFAQFNLGNRHAADGDTPANVEHNRQLLQQGLGLPSTPHWLRQVHSSTVLRFTAPPVPGASEPVADAAVTSVPGVVLAILTADCLPVVFAAADGSEVGAAHAGWRGLADGMLEATVAAMQTPPAQLRAWLGPAAGPADYEIGEEVYHAFVGHDPAAEAAFVATRAGHWKVDLFALARQRLQAAGMDPAQVHGGTVSTMADPDLYSHRRDRRTGRMATLAWIAP
>NC_010943.1|WP_005410789.1|3825033_3826023_-|23S-rRNA-pseudouridine(1911/1915/1917)-synthase-RluD
MSEQPSESARQAIVPDTAAGRRFDAVVAELFPEYSRSRLTEWIKAGEVLLDGAQVRPRDPLRGGEVVTLNVVLETQTDAQPEDIPLDVLFEDEHLLVINKPVGLVVHPGAGNHSGTLVNALLFRDPSVAVLPRAGIVHRLDKDTSGVMVVAKTLEAQTALVEQLAARDVHRQYLAIVMGALVAGGTADAPIDRHPRDRLKMAVREDGKEAITHYRLRERFRAHTALECRLETGRTHQIRVHMAHVRHPIIGDPLYGGALKLPKGASDELVAALRGFKRQALHAETLEFTHPITGELVRNTAPVPEDMLHLMKVLREDSEAFAARERDRW
>NC_010943.1|WP_012481093.1|3826136_3827024_+|outer-membrane-protein-assembly-factor-BamD
MIRRSSMLSAPVRLTALLLVLVIAATGCHRGAKKGDRPDEGTPVEQLYEKSHKLMQGGNWSGAETSFRRLVAQYPYGPYTEQAMIETAYAQYKAGKHDDAVSSIDRFIRTYPTHRNIAYLYYLRGLANSNRSTVFLRRVWSLDASRRDLSTPHQAYSDFNIVVDRYPNSRYAADARQRMLELRDVFAQHELDNALYYMRRGAWVSAAGRANYLLETYPQSAFQYDAVAVLADSYTHLGNKTLADDARRVLQLNQPDHPWLEGKWPKYPWMIRKLNPFAGEKSASTGQRSARLEKK
>NC_010943.1|WP_044570773.1|3827214_3828417_+|lipase
MTPPPRRFRPLACLLATALLALSSGPVAAAPPAPGDLLSAAPYRAPWVPSKAAQAYKLHYRTPDHRGQLAEGTGLLYLPAGAAPAGGWPVVSWAHGTQGIADRCAPSVSGPYQPERDGRFLDQFLAQGYAVVAADYQGLGSPGDHAYLHVRTAARNAIDLVKASRQYLGTATLSPRWVSVGHSQGGAAALTAGHLAPTYAGPSLHYRGSFTTGTPTAVELTALVMKPDNRTANPGALNAYHAYLLDGLLQVAPQIDRVLSDTGRTRVAVAREQCLGELATTLDGADTGSMFTAPLTSVPGIWAVLYDYLGVPRRGFSQPLMLGHGSEDRDVPYLTTLLYAAGLALRGEPVAFRRYPVDHRGTLDAAAADGLAFVRARLEDGHFNDAAETAGLEQLLDDAR
>NC_010943.1|WP_012481095.1|3828904_3830539_-|NAD+-synthase
MASIRIAMAQFDFPVGDVAGNTERIIEMIGQARDEYGAELVMFPELAVSGYPPEDLLLRPGFLYECEQAMARIATACRGITAVVGWPQAAGAVVYNAASVLRDGLVEQTYRKRELPNYAVFDERRYFDVDPDGGSCVFEVNGIPVGLLICEDLWFAEPLADTVRAGAQLVVVPNASPYERGKHAQRDAVLAARTRESGAAIAYLNVVGGQDALVFDGASVVADGDGTVHPAAAAFVDQWLLVEYDGQTRRFMPHVWMDDGDESMDALAWRAVTRGIQDYCRKNGFKKVWLGLSGGIDSALVLALAVDALGAENVTAVRLPSRYTAGMSNDLAAEQCQALGVKLEAVSIEPAFKGLMESLAPMFEGTAPDVTEENLQSRSRGVILMALANKFGGLLLTTGNKSEYAVGYATIYGDMCGGYAPLKDLYKTEVFGLSKWRNTVGGAPVIPPAVISRPPSAELRENQLDQDSLPAYDVLDGILYRYIDQEQSRTEIVAAGYDAAVVDRVLRLVRISEWKRHQAAPGPKVSRRAFGRERRYPISNGYKG

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Crispr_ID: NC_010943_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_010943_12

3924991-3925103

Orphan

Consensus_repeat	Method
GCGTGCCAACCAAGGTTGGCACCTACCGAAGGCGGGTGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_010943_12

>merge|NC_010943|12|3924991-3925103|CRISPRCasFinder
GCGTGCCAACCAAGGTTGGCACCTACCGAAGGCGGGTGCGGCGGTAGATCCGCGCCATGCGTGGATGGGAAAGCGTGCCAACCAAGGTTGGCACCTACCGAAGGCGGTTGCGG

>NC_010943|12|12|3924991-3925103|CRISPRCasFinder
GCGTGCCAACCAAGGTTGGCACCTACCGAAGGCGGGTGCGG	CGGTAGATCCGCGCCATGCGTGGATGGGAAA
GCGTGCCAACCAAGGTTGGCACCTACCGAAGGCGGTTGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_010943.1\|WP_012481149.1\|3922760_3923270_-\|giant-cable-pilus-fimbrial-subunit	unknown	unknown	gnl\|CDD\|367947
NC_010943.1\|WP_012481147.1\|3918841_3919987_-\|minor-pilin-and-initiator-protein	unknown	unknown	gnl\|CDD\|284778
NC_010943.1\|WP_005410877.1\|3933427_3933727_-\|DNA-directed-RNA-polymerase-subunit-omega	unknown	unknown	gnl\|CDD\|234744
NC_010943.1\|WP_012481148.1\|3919983_3922710_-\|TcfC-E-set-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|185210
NC_010943.1\|WP_012481143.1\|3909672_3912096_+\|penicillin-binding-protein-1A	unknown	unknown	gnl\|CDD\|227342
NC_010943.1\|WP_005410871.1\|3926816_3927059_-\|type-B-50S-ribosomal-protein-L31	unknown	unknown	gnl\|CDD\|234969
NC_010943.1\|WP_044570801.1\|3914060_3918050_-\|YadA-like-family-protein	unknown	unknown	gnl\|CDD\|240612
NC_010943.1\|WP_012481142.1\|3908394_3909477_-\|pilus-assembly-protein-PilM	unknown	unknown	gnl\|CDD\|378558
NC_010943.1\|WP_005410863.1\|3913247_3913991_-\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_012481153.1\|3934792_3937861_+\|formate-dehydrogenase-N-subunit-alpha	unknown	unknown	gnl\|CDD\|273689
NC_010943.1\|WP_012481150.1\|3923788_3924877_-\|membrane-protein	unknown	unknown	gnl\|CDD\|236090
NC_010943.1\|WP_012481152.1\|3928470_3930582_-\|ATP-dependent-DNA-helicase-RecG	unknown	unknown	gnl\|CDD\|236794
NC_010943.1\|WP_012481151.1\|3927147_3928086_-\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|239115
NC_010943.1\|WP_005410876.1\|3931159_3933322_-\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NC_010943.1\|WP_012481154.1\|3937871_3938789_+\|formate-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|273705
NC_010943.1\|WP_005418950.1\|3925242_3926520_-\|citrate-synthase	unknown	unknown	gnl\|CDD\|180164
NC_010943.1\|WP_005414350.1\|3912426_3913071_+\|hypothetical-protein	unknown	unknown	unknown
NC_010943.1\|WP_005410878.1\|3933837_3934503_-\|guanylate-kinase	unknown	unknown	gnl\|CDD\|234719
NC_010943.1\|WP_012481146.1\|3918117_3918825_-\|giant-cable-pilus-chaperone-protein	unknown	unknown	gnl\|CDD\|237939
NC_010943.1\|WP_005410875.1\|3930589_3930976_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|129116

Protein	Function_ID	Function_description	E-value
NC_010943.1\|WP_012481149.1\|3922760_3923270_-\|giant-cable-pilus-fimbrial-subunit	gnl\|CDD\|367947	pfam04449, Fimbrial_CS1, CS1 type fimbrial major subunit. Fimbriae, also known as pili, form filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometres. They enable the cell to colonise host epithelia. This family constitutes the major subunits of CS1 like pili, including CS2 and CFA1 from Escherichia coli, and also the Cable type II pilin major subunit from Burkholderia cepacia. The major subunit of CS1 pili is called CooA. Periplasmic CooA is mostly complexed with the assembly protein CooB. In addition, a small pool of CooA multimers, and CooA-CooD complexes exists, but the functional significance is unknown. A member of this family has also been identified in Salmonella typhi and Salmonella enterica.	2.2064e-20
NC_010943.1\|WP_012481147.1\|3918841_3919987_-\|minor-pilin-and-initiator-protein	gnl\|CDD\|284778	pfam07434, CblD, CblD like pilus biogenesis initiator. This family consists of several minor pilin proteins including CblD from Burkholderia cepacia which is known to CblD be the initiator of pilus biogenesis. The family also contains a variety of Enterobacterial minor pilin proteins.	1.33133e-50
NC_010943.1\|WP_005410877.1\|3933427_3933727_-\|DNA-directed-RNA-polymerase-subunit-omega	gnl\|CDD\|234744	PRK00392, rpoZ, DNA-directed RNA polymerase subunit omega; Reviewed.	1.39874e-21
NC_010943.1\|WP_012481148.1\|3919983_3922710_-\|TcfC-E-set-like-domain-containing-protein	gnl\|CDD\|185210	PRK15310, PRK15310, fimbrial outer membrane usher protein TcfC; Provisional.	0
NC_010943.1\|WP_012481143.1\|3909672_3912096_+\|penicillin-binding-protein-1A	gnl\|CDD\|227342	COG5009, MrcA, Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane].	0
NC_010943.1\|WP_044570801.1\|3914060_3918050_-\|YadA-like-family-protein	gnl\|CDD\|240612	cd12820, LbR_YadA-like, YadA-like, left-handed beta-roll. This group contains the collagen-binding domain virulence factor YadA an adhesion proteins of several Yersinia species, and related cell surface proteins, including Moraxella catarrhalis UspA-like proteins. The collagen-binding portion is found in the hydrophobic N-terminal region. YadA forms a matrix on the bacterial outer membrane, which mediates binding to collagen and epithelial cells. YadA inhibits the complement-activating pathway with the coating of the cell surface with factor H, which impedes C3b molecules. These domains form a left handed beta roll made up of a series of short repeated elements. UspA1 and UspA2 are part of a class of pathogenicity factors that act as cell surface adhesion molecules, in which N-terminal head and neck domains extend from the bacterial outer membrane. The UspA1 head domain of Moraxella catarrhalis, is formed from trimeric left-handed parallel beta-helices of 14-16 amino acid repeats. The UspA1 head domain connects to a neck region of large extended, charged loops that maybe be ligand binding, which is in turn connected to an extended coiled coil domain that tethers the head and neck region to the cell surface via a transmembrane region.	1.22166e-19
NC_010943.1\|WP_012481142.1\|3908394_3909477_-\|pilus-assembly-protein-PilM	gnl\|CDD\|378558	pfam11104, PilM_2, Type IV pilus assembly protein PilM;. The type IV pilus assembly protein PilM is required for competency and pilus biogenesis. It binds to PilN and ATP.	6.34476e-170
NC_010943.1\|WP_005410871.1\|3926816_3927059_-\|type-B-50S-ribosomal-protein-L31	gnl\|CDD\|234969	PRK01678, rpmE2, type B 50S ribosomal protein L31.	3.97798e-51
NC_010943.1\|WP_012481153.1\|3934792_3937861_+\|formate-dehydrogenase-N-subunit-alpha	gnl\|CDD\|273689	TIGR01553, Formate_dehydrogenase_major_subunit, formate dehydrogenase-N alpha subunit. This model describes a subset of formate dehydrogenase alpha chains found mainly in proteobacteria but also in Aquifex. The alpha chain contains domains for molybdopterin dinucleotide binding and molybdopterin oxidoreductase (pfam01568 and pfam00384, respectively). The holo-enzyme also contains beta and gamma subunits of 32 and 20 kDa. The enzyme catalyzes the oxidation of formate (produced from pyruvate during anaerobic growth) to carbon dioxide with the concomitant release of two electrons and two protons. The electrons are utilized mainly in the nitrate respiration by nitrate reductase. In E. coli and Salmonella, there are two forms of the formate dehydrogenase, one induced by nitrate which is strictly anaerobic (fdn), and one incuced during the transition from aerobic to anaerobic growth (fdo). This subunit is one of only three proteins in E. coli which contain selenocysteine. This model is well-defined, with a large, unpopulated trusted/noise gap. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport].	0
NC_010943.1\|WP_012481150.1\|3923788_3924877_-\|membrane-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	5.57878e-06
NC_010943.1\|WP_012481152.1\|3928470_3930582_-\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NC_010943.1\|WP_005410876.1\|3931159_3933322_-\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NC_010943.1\|WP_012481154.1\|3937871_3938789_+\|formate-dehydrogenase-subunit-beta	gnl\|CDD\|273705	TIGR01582, Formate_dehydrogenase_iron-sulfur_subunit, formate dehydrogenase, beta subunit, Fe-S containing. This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport].	1.87421e-156
NC_010943.1\|WP_005418950.1\|3925242_3926520_-\|citrate-synthase	gnl\|CDD\|180164	PRK05614, gltA, citrate synthase.	0
NC_010943.1\|WP_012481151.1\|3927147_3928086_-\|nucleoside-hydrolase	gnl\|CDD\|239115	cd02649, nuc_hydro_CeIAG, nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal proteins similar to the purine-preferring nucleoside hydrolase (IAG-NH) from C. elegans and the salivary purine nucleosidase from Aedes aegypti. C. elegans IAG-NH exhibits a high affinity for the substrate analogue p-nitrophenylriboside (p-NPR). .	2.44826e-118
NC_010943.1\|WP_005410878.1\|3933837_3934503_-\|guanylate-kinase	gnl\|CDD\|234719	PRK00300, gmk, guanylate kinase; Provisional.	5.54639e-121
NC_010943.1\|WP_012481146.1\|3918117_3918825_-\|giant-cable-pilus-chaperone-protein	gnl\|CDD\|237939	PRK15308, PRK15308, fimbrial protein TcfA.	1.61117e-49
NC_010943.1\|WP_005410875.1\|3930589_3930976_-\|RidA-family-protein	gnl\|CDD\|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	1.07399e-58

>NC_010943.1|WP_012481150.1|3923788_3924877_-|membrane-protein
MSTRFDPPERGPLGPDVAAVVTAPIVAPPSESAVSWGAIFAGATAAAALSLILLILGVGLGLSSVSPWSFEGVSKETFGWSSIIWLTFTALAASGLGGYLAGRLRTKWTQIHGDETYFRDTAHGFVSWAVATLLTAGLLTSAIGGVLGAGAKVAGAAAGVAASTAGVAAAGAGSTAAAAPEGDLNYWVDSLFRNATDAGPAAAGAPPAPGAPDAASGVAATDPAPPPPAASVGPRDVRVGLPPRPMPGNGPMGDRREVRAEVNRIIVNSLQGDGLDPADTQYLAQLIARETGMSPAEAQARVTDVQTRMRAALEKARNTAKQAADDARKATAYAALWLFITLLIGAFFASLSATWGGRRRDL
>NC_010943.1|WP_012481149.1|3922760_3923270_-|giant-cable-pilus-fimbrial-subunit
MHAIIKKAALAAALATASLSAHAVETKISVYADVDPTLALLRDDGTPLPDMVTLTHDPLRGLIPNTQRVRIHSNDDKADIEARIDGSFFLANETGTVTVPMTISLNNRALGAAAIEYKAADLFNGAGSTPGASISMPLTIAQTTPAPILTKGAYSGLVNVVLNQKAATP
>NC_010943.1|WP_012481148.1|3919983_3922710_-|TcfC-E-set-like-domain-containing-protein
MTLHAPAVTRLAVALALALSTPLAAARGVPPGFEDLVEGQTEQLDIQLFGRSAGLSPVRVTLEHVQLEDPARVLQSLDLPAEAQAALLPALSQPLPRNSHLACRFGGASAGCGYIDPPEAPDEVRALYDEGEGAVRLFVARQWIPGKPAAERFHTVTANAENAFLHQQTLNLSGGRDYQSLSARGVGTLGLFDRGHLSAEWYYNQQRYRSHSDDDFQFDNVYYRHDLGPAHYLQAGRMDRRNLSSPQGGTFSFSMLPLDRFQGARLGTTQAYVDTDAAVQASPLTVLLARDARVDVFDGERLLQTFYLQAGINQIDTRNFPFGNYLVRMRIYEDGVLVRTEEAPFDKGGDWTNSQWQWFVQGGHRNERRSDAFDGERIAMAGVRVPLGRDAAMTAGAATFGGHRYGELRLDLRRVMATQEVRATFSGMRGSDGSNGQQHQLSYRRTASWNLYQQRMRGKACQFEAEARDQLGCTNALSGSMSLPLAGGNVYVGYTRRQTWRTGWHRPEFEQDPLFGLEPLLPPGPLEPRREPLLSRTWQASFSRSHRWQDFSVSTRVGVWRQNSTDSVRGSTERDRGIYVNLSLSRRHRSAAGDGQRRYAVDVRQPQHQRPAIDYSVGQSLRQELDTQYRELSGELRANNNERYSASLGGQLQNGIGHTSASLARYQQRGRSETGYSGAHSSGFALGRRGFYWSGANGADAGLAVQVADTDDADLRGVAAELQVGGLRRQRLQIGERRLLPLPAYQSQRAEVQDASTLDSIAAIRVTGVGGARPMFLTPGKLMRMPVPIEVTYTFIGHARDLAGAPLGGARILNAPVPGTSANGGFVADFPRRETTLYLLQDDRLLHCPLQVRERRQVVLLVGAVHCEPLAVAQLPAEIRQQARVTRLLQERALIAATPRTAAAGGTP
>NC_010943.1|WP_012481147.1|3918841_3919987_-|minor-pilin-and-initiator-protein
MNRRWMFVLMLVSALVLVMPRAWAQWPPETHPADQSRDIVMSWDRSAVPGDVELWAPRTVLGFSHDLALKYGQIHVVCESASDSEFGRCPTEGALPLITGTSEVMLRLVEQRTGLTAEVRAIGSLQRVMSGRVCAGDFWEESPRPLYSAFWFRCGVGTGADEPIGAGIELALPQREISRLVAGHWKATMRLNIKADPAAAPVATATFNFDFTVTDYDAISIYFPTFDTVAPLVNLDLRYDPIQKVVGGRKQLDMCLYDGLGSQSEYLDVTVRDSGPRPPAGSDFSLWHRDGGSDASQRLDYRVHLDYGGHRLAMKHNVKQQLRGIDSAQLRLVMLPGISQPVYCVPTPLTLETPPTPIASQRPGLYEGELTVVLDVPTAKP
>NC_010943.1|WP_012481146.1|3918117_3918825_-|giant-cable-pilus-chaperone-protein
MKKLLFCLLPVSALLALPAHANLSIHPMRAAVDAKRGTQIRVYSQSTIPQYVQTRLRRIVNPATPAEEEQEMEASDAAIAITPGKFALSGGGNRLIRVIPLQQVQKETAYRLYFEGVRGPDDAPLEDGEGAQANIGVSLVWGALVNVTPDDGVVDLRLQDNTLHNTGTLRVGIIGAEQCTAAGVCTPHPVSHSLYPDAALTLPFQLQPGNSLQLRYRLTRDGYREHVRTIAPTTT
>NC_010943.1|WP_044570801.1|3914060_3918050_-|YadA-like-family-protein
MNRIYRRIWNHAKGCWEVASELTRPCGRKASRVTGAGGLLMVALLLAGGEVHAKTRYYIGCDPFNLGNGEFVSCSPIAGRYDDTMFVGYALTNGLNSLGYGAGVNMRGDNTTAFGIGARIDGQNSAAFGFKARTSGVDSVAFGYNASANGGHALAMGANAYTGALGATAVGNDAAATRQNAVALGSGSSAEKENAVALGANALSNGVDGVALGSKAMVDTGAGTGGVAIGGGARAGSWGYTGAIAIGGDTRAYIDGVALGYAASASAQGAVALGVRSVATEANTVSVGSASVRRRIVNVADGRVTASSTDAVTGKQLHAMNERVDGMIKQDSAGGVVRIANSNTGSEVSMRNAVLATRKVSGVSDGALTTTSTEAVNGRQLNTTNGNVIKAQTAAGEAKSDASNALTQVVTLGGLVGEVSATGNVRLGEKNSGTVLDVRNSANANRKLAGVADGVVSASSYEGVNGRQLNATNDKVAAVESIARAAGTEAAAAKTDAAKALVETAALGGLVAQVSTTGNVRLGERNSGTTLDVRNSANANRKISGVADGLIDAGSTEAVSGRQLHASNGRISELESTNQYISVGVDSFSERAEAALLGVAVGDSAKAGAEGGTALGAFAAALGKNSVAVGRGAGVSGEASGGFAMGAGAQVHAVNGVAIGAGAVVEGSAAGSLAFGAGSFADETDTASFGNATNQRRLAYIARGSADHNATAVSQLRDSLATLGGGAGMDASGNIIAPTYSVQGGTQSTVEDALMALDGAVITAGRRAGKMEDQLSSIFQDSPSARADGMNQIALSGVSGMVLTNLADGRVAPGSRDAVNGSQLYAAEQKISQNRNDLEAMRMEREMGQQAMRGLDSSVIDYGGARLTGVSDGSVSADSHDVVTGRQLFGVSDRVSKIEHQGRFLKIDTDQLSEDAFAGFLGVAIGDSARTQGEGGTAVGSFASSLGVNSVAIGRGSSVSANSLNGFAVGAGAHVASTNGVSIGASSRVHAGAEGSLALGVGSEATEAGTASFGSAGTERRLVNIANGTANHNAATVGQLRGALSALGSEVDANGNIVGPTFTVQGQSQSTLNGALEALDGAVVSNRSRVNQVESQLRSVFQDTSSVRADGLNQLTLAGTHGMVISNVANGLIAAGSRDAVNGGQLYSMQQQLNGRIDGLEERIDAPQPRAMAVASVPEPEAPVPLADGGQQVASVGEGEKPAPQPKTKKDETPKPQVDTAELEKMLARANEYTDGAISNFERRLDKMDKRFNRMAAMSSAQTAMAMNTAGLATYNRLGAGVGYSEGESAMAVGYQRVLNEKGSATFSLNGAFTNSGERSMGVGVGIGW
>NC_010943.1|WP_005410863.1|3913247_3913991_-|hypothetical-protein
MYRWVRGIISYRTFYIWRARFRYYTRNLDLWTLMSGLCIAGLLLVLWYLWQMLGVPPPRVHPQAAALRIDGVTSEAIHRIVLVRHAGSTPGAPFTTPEEVRASTLRTMRVRQVMDSEVVWRLKADMLADIADYITATGGCFPYNCRRVLDRLDYVRQAGVENAQINAALSTVLEVPLDQMPPLEADEHERVKSGWSDGFDDIYYQSWLLRDLQVMHAQMMREYPQRAPAPWLPRLFSDPLRDTRFVW
>NC_010943.1|WP_005414350.1|3912426_3913071_+|hypothetical-protein
MHRARQHAASQTRERRHRLAHEAARLMAEGGIRDYHQAKLKAASRLGIHDDASLPRNTEIEDALREYQRLFSGPQHGNELQRRREAAMRALEFLHGFAPRLAGPVLEGTADANSPVQLHLHSDDPEAVHRFLDEHGIPAESRTRRLRMDRERSLDVPVWVFSAEELTFDLAVLPYDALRQAPLSPVDEKPMRRASVTQLRQLLAEAEITAYIGG
>NC_010943.1|WP_012481143.1|3909672_3912096_+|penicillin-binding-protein-1A
MTRLRRWLRWIFLIVLVLALIGAAAVGGLYYAVSSKLPDVQTLRDVEMQEPMYVYAADGKLMAVFGETRRTPITMKDVPERLKQAFLATEDARFYEHGGVDYMGIGRAVWLLATTNDKRVPGGSTITQQVARQFFLSSEYSYTRKLAEILLARKIESELSKDEIFELYLNKSFFGNRAYGVAAAAEFYYGKKLNELDLDEMASLAGIPKFPSSGNPISNPERARQRRDNYVLQRMADLKFVSQAEADAAKAVPMHATAHEPPVQVDAPYVAELVRQEMIARFGGDVVNKGYHVTTTIDSTLQTAANQSVRDGLLLYDHRHGWHGVEKQVQVGAGEDAAALAEHLRGMYGQAGLLPAIVASTGADGSATVVLANRSEIVLPAGAAKWTNKTPGKLVQRGDIVRVRAGAKEGEWLLDQIPRGQSALVSLDAHNGALKALVGGFSFSGNKFNRATQARRQPGSSFKPFIYAAAFDKGYNPASIVLDAPVVFRDRRGKTWAPQNDGGGFRGPMRLREALVQSRNLVSVRLLDGMGVDYARKYISEFGFAESELPPNLSMSLGTASLTPLSVARGYAVFANGGSRVDTWLIDQVNDRDGNLVFKENPALACRDCAGSSDQPVNQVVDGFNFGAPAPKVDPAAAAKAEAKTETPAAPANPDARTAPRAIDARTAYQLVSMMRDVVQRGTGVQAKVLGREDVGGKTGSTNDHRDAWFSGFGGPYVTTVWVGRDDFRSLGYREYGGKAALPIWIDYMRTALKDTPVAQNEPPSGMVQATLNGATEWVKVEDMDRLTDYDLNLNTPQADAAAFDIF
>NC_010943.1|WP_012481142.1|3908394_3909477_-|pilus-assembly-protein-PilM
MPVGRGETVGLIPKSQSPLVGVDISSTAVKLLQLSRSGNRFRVEHYAVEPLPPNAVVEKNIVEVEAVGEAIRRAMNRSGSKAKLAAAAVAGSAVITKVIPMPAELDENDMEAQIELEAVNYIPYPIEEVNLDFEVIGAIPNNPEMVQVLLAASRSENVELRQSALELGGLQAKVMDVEAFAVENAYALVASELPVSIDGVVALVDIGATMTTLNVLRGGRSLYSREQVFGGKQLTDEIMRRYGLSYEEAGLAKRQGGLPESYEMEVLEPFKEATVQQISRLLQFFYAGSEFNRVDHIVLAGGCAVLGGLPEMVEEQLGVPTVVANPLAQMTLGPKVNAHALAQDAPALMIATGLALRSFD
>NC_010943.1|WP_005418950.1|3925242_3926520_-|citrate-synthase
MSDLDQVTLNAGDKSVVLPVIKPTLGNDCVDIAKLTKETGFFTYDSGFTATASCKSAITYIDGDKGVLLYRGYPIEQLSEKSSYVEVAYLLINGERPSAEQLKAFTDELTAEANVDDSINTLIGSFAKDAHPMAILAAAIAQLSAIYHDSLDLSDAEQRRKAAVRLIAKVPTLSALIYRHGKGLPANKPDTSLDYVSRFLKQTFESADGQYDLNPDVVKALDLLFILHADHEQNASTSTVRLVGSTGANPYASVAAGVTALWGPAHGGANEAVLKMLEEIGSADNVESAVVKAKDKTSGFRLMGFGHRVYKNFDPRAKVIGEMTSKVLKQLGVQDPLLDVAVKLEQAALQDEYFVARKLYPNVDFYSGIIYKALQIPTEMFTVMFALGRTSGWVSHWLEQQVDPEMKIGRPRQVYTGSDVRDYQG
>NC_010943.1|WP_005410871.1|3926816_3927059_-|type-B-50S-ribosomal-protein-L31
MKADIHPNYRDVVFHDVTSDFKILTRSTMATKETIQWEDGNEYPLVKVEISSASHPFYTGKHKVIDTSGRIDKFQKRYAR
>NC_010943.1|WP_012481151.1|3927147_3928086_-|nucleoside-hydrolase
MTHKIPLLIDTDPGVDDALALLMAFADERHDVVALTIAAGNVGLQYTVRNALKLCDIVGRTDVPVFAGSPDPLLHPSVDAAHVHGRDGYGDVDLPPPSRQAEAEHAALAILRLSHEHAGELMLVMLGPLTNLALALKLDPTLPERIKRIVVMGGAVTCHGNITPAAEFNIAFDPEAAHVVFTSFKHLLVSDWEATVAHGLPLQDAEKWLQADSDRARFYELISCKTRGLSEDSKGGRWYTADAVAMAWALNPEGQLRVESRPLNVELNGTFSRGATIVDWNRQTGQPDNCDLLMAYDQQRFEALVRQALGAD
>NC_010943.1|WP_012481152.1|3928470_3930582_-|ATP-dependent-DNA-helicase-RecG
MARKAAVTPVLSPSGEASLAMLAGVGPAVAAKLQARGLATLQDLWLHLPLRYEDRTRLTRIEDLRNGVPAQVEGRVVAVERGMRYRPMLKVAVEDEGRGTLVLRFFHFRQQQVGQFAVGNRLRCFGTPKPGQLGLEIVHPSYQVLGRNDDPELGDRLDPVYPTVEGVGPMTMRKLIGQALDRLPEESALELLPSGWLDGLGLPSLRSALLTVHRPPPDADLVALAAGTHPAQRRLAMEELLAHHLSLRRQRIALQAHHAPPLAGPGKLAKALLKQLPFALTGAQARVFKQIREDLARPSPMLRLVQGDVGSGKTVVAALAAMLAVEQGKQVALAAPTELLAEQHLNNLRGWLEPLGVRIAWLAGKVTGKARAKVMEQVASGEAQVVVGTHALMQEAVVFQDLALAIVDEQHRFGVHQRLALRDKGAGGNSVPHQLVMTATPIPRTLAMSEYADLDVSAIDELPPGRTPVQTVALNNDRRPELIERIALACQEGRQVYWVCTLIEESEELDATPAQATYESLQALLPGVRVGLVHGRLKAAEKLATMVAFKAGDIDLLVATTVIEVGVDVPNASLMVIENAERLGLAQLHQLRGRVGRGSAVSRCVLLYQAPLSQMARERLQTMRETNDGFVIAEKDLELRGPGELLGTRQTGLAGFRIADLARDAGLLPGVHDLAERLLDQQPTLADRVVQRWIGTAVRYASA
>NC_010943.1|WP_005410875.1|3930589_3930976_-|RidA-family-protein
MSRQIINTEKAPAAIGPYSQAVRAGNTVYFSGQIPLDPATGDIVGAGDVEAQARRAFDNLKAVAEAAGGSLDKVVRLGLYLTDLGEFAKVNAVMQDYFQAPYPARSTIEVSGLPKGANFEVDAVMVID
>NC_010943.1|WP_005410876.1|3931159_3933322_-|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MNPGPTAKVAAAPAAAVPDYVLQLERAAHYLPPEQLPLLRRAWEVGASAHAGQTRKSGEPYITHPVAVAQVLAELGLDVEALIAAILHDTIEDTPLTREALAAEFGEAVAELVDGVTKLDKLKFRDRQEAAAESFRKMLLAMSRDLRVIMIKLADRLHNMRTLGAQSREARGRIARETLEIYAPIAQRLGMSLVKSELQNLGFKALYPWRHAIIEKHIRSQPVVRREAMAQVEVQLSQRLAKEGIEHRLISRIKTPWSIYNKMRDENKSFDQVMDVFGFRLVVRSVPSCYHALGSVHATFKPLDGRFRDFIAIPKANGYQSLHTVLFGPYGSPIEVQIRTEEMDLIAERGVAAHWTYKFGGDSPNSAQSRAHAWIVELIDSQRAAGSSLEFLDNVKVDLFPDEVYLFTPKGKILALPRNSTALDFAYAVHTDVGNMAVASRVDKKLVPLRTKLVSGQSVEIITARSATPKPQWLEFVVTSKARTAIRHQLKQLEHEDAVQLGHRMLDRALEAMDSSLERLPKGRLDAFLAEHRFPRLEALLAEVALGNWMPTQAAQALMAYAELRGGPHSRHHSQEKILINGSERGVVTFAGCCQPIPGDEIMGYHTAGKGIVVHRMDCPNLAELRKSPERWVPIGWDTTVSGDYDTSLVVEVENGTGVLAQLAAAIAQSHSNIERVDYLDRDFNAAVLAFNIQVRDRNHLAEVMRRLRRLSVVQSVRRQ
>NC_010943.1|WP_005410877.1|3933427_3933727_-|DNA-directed-RNA-polymerase-subunit-omega
MARITVEDCLEVVNNRFELVMMASKRARQLANGVQATLDNSETEDKPTVLALREIAARKIDNALIDEVEKAERERAEREALEWAAAEVVADEDMSKNDD
>NC_010943.1|WP_005410878.1|3933837_3934503_-|guanylate-kinase
MSAPSKPSDAVARGTLYIVAAPSGAGKSSIVNATLARDPQIALSISFTSRAMRPGEVNGQHYHFVSAEKFEQMIAAGDFFEHAWVHGDWKGTARQSVEPQLAAGQDVLLEIDWQGAQQVRQLVPGTVTVFILPPSKQALQDRMRKRGQDSEAVIAQRLGAARDEMLHFNEFDYVIVNEVFDTAVDELCAIFTASRLRREAQKVRHAGLIQALLTPDPGATD
>NC_010943.1|WP_012481153.1|3934792_3937861_+|formate-dehydrogenase-N-subunit-alpha
MPSMSRRQFLKVTGTTLVGSSLALMGFAPGIALAEVRQYKLTRATETRNTCTYCSVACGILMYSLGDGAKNAEPSIFHIEGDPDHPVNRGTLCPKGAGLADIIHSKSRLLYPEYRAPGSNEWKRLSWDDALDRIARLMKEDRDANFVQKNEAGQTVNRWLTTGMLAASATSNETAVLTHKVVRSLGMLAFDNQARVUHGPTVAGLAPTLGRGAMTNHWVDIKNADLILIMGGNAAEAHPCGFKWVTEAKAHNKARLIVVDPRFNRSAAVADVYAPIRTGTDIVFLGGLINYLLTEDRIQHEYVLNYTDMSFLVKDEFAFKDGLYSGYNAEKRSYDRSSWDYAYGDDGFVRSDPTLKDPRCVYNLLKQHYARYTVEMVERICGTPADSIRQIWDMIASTAGKDKAMTILYALGWTQHSIGAQNVRAGTMVQLLLGNIGVAGGGMNALRGHSNIQGLTDIGLMSDLLPGYLTLPKQDEQDYEAYIAKRTQKPLRANQMSFWQNYPKFHVSLMKSWWGDAATADNNWCFDYLPKLDKPYDMLQAYELMNEGKIHGYICQGFNPLASAPNKGKLISAFSKLKFMVSMDPLETETIAFWQNHGALNDVDPSTIQTEVFRLPTTSFAEENGAVVNSSRWLQWHWKGANPPGEARSDIEIMSELFHRIKAMYEKDGGAWWEPVRDLVWNYANPEVPTPEELAMEYNGKALTDVFDPKDPTKLVRKAGEQLAAFGDLRDDGSTASGCWIYIGAWGPTGNMMARRDNSDPTGIGNTLGWAWAWPANRRVMYNRASCDVAGKPFDPRRTLLAWNGKNWGSVDVPDFKADEDPAGGMGPFIMNPEGIARFFAKAGMAEGPFPEHYEPFDTPLRSNPLSPGQALTLNNPAARVFASDRAQIGSPDEFPHVATTYRLTEHFHFWTKHGKLNAIIQPEQFVEIGAALADELGINNGSRVRVSSKRGHIEAVAMVTKRIKALQIDGRTVHQVGVPIHWGFLGAAKPGYIANTLTNAIGDGNSQTPESKCILVKVEKV
>NC_010943.1|WP_012481154.1|3937871_3938789_+|formate-dehydrogenase-subunit-beta
MSLQSLDIIRRSATTTPSPEARGAHTGQVAKLIDVSKCIGCKACQVACMEWNDLRDEVGSCVGSYDNPPDLSEQSWTVMKFREYEDEKGKLEWLIRKEGCMHCSDPGCLKACPSPGAIIQYANGIVDFQEENCIGCGYCVTGCPFDVPRISKKDHKAYKCTLCSDRVAVGQEPACVKTCPTGAITFGSKQAMTEHAAGRVEDLKSRGYENAGLYDPQGVGGTHVMYVLQHVDKPELYADLPKDPRISPMVEVWKGVAKPLGVLAIAATAFAGFLHYIGIGRNTVNDEEEEEAEHEAKKIEEEQRP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP014142	Thermus parvatiensis strain RL plasmid pTP143, complete sequence	129058-129084	2	0.926
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NC_017588	Thermus thermophilus JL-18 plasmid pTTJL1801, complete sequence	233694-233720	2	0.926
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NC_017273	Thermus thermophilus SG0.5JP17-16 plasmid pTHTHE1601, complete sequence	252891-252917	2	0.926
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_AP019795	Thermus thermophilus strain AA2-29 plasmid pAA229, complete sequence	115011-115037	2	0.926
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_LR027520	Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence	170018-170044	2	0.926
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_AP019793	Thermus thermophilus strain AA2-20 plasmid pAA220, complete sequence	144425-144451	2	0.926
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NC_016626	Burkholderia sp. YI23 plasmid byi_1p, complete sequence	1388337-1388363	3	0.889
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP021119	Streptomyces sp. CLI2509 strain CLI2905 plasmid unnamed1, complete sequence	72186-72212	3	0.889
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	61311-61337	3	0.889
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP022363	Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence	294537-294563	4	0.852
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	259059-259085	4	0.852
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	KU996353	UNVERIFIED: Streptomyces silaceus strain ACCC 40021 plasmid, complete sequence	3038-3064	4	0.852
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP032344	Azospirillum brasilense strain MTCC4038 plasmid p5, complete sequence	29001-29027	4	0.852
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP033317	Azospirillum brasilense strain Sp 7 plasmid p5, complete sequence	101261-101287	4	0.852
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NC_013855	Azospirillum sp. B510 plasmid pAB510a, complete sequence	259866-259892	4	0.852
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP033323	Azospirillum brasilense strain Cd plasmid p5, complete sequence	230301-230327	4	0.852
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP012919	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p5, complete sequence	5758-5784	4	0.852
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP012919	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p5, complete sequence	154447-154473	4	0.852
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NC_009468	Acidiphilium cryptum JF-5 plasmid pACRY02, complete sequence	159550-159576	4	0.852
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1449377-1449403	5	0.815
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP040820	Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence	159128-159154	5	0.815
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP025613	Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence	418213-418239	5	0.815
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP048631	Ancylobacter pratisalsi strain DSM 102029 plasmid pLGM, complete sequence	25757-25783	5	0.815
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	902068-902094	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NC_016624	Azospirillum lipoferum 4B plasmid AZO_p5, complete sequence	234954-234980	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP032054	Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence	503837-503863	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP016560	Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence	161093-161119	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP054625	Cupriavidus gilardii strain FDAARGOS_639 plasmid unnamed1, complete sequence	32767-32793	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP054618	Azospirillum oryzae strain KACC 14407 plasmid unnamed4, complete sequence	116462-116488	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	MK059749	Mycobacterium phage CRB2, complete genome	30771-30797	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_CP049031	Fluviibacterium aquatile strain SC52 plasmid pSC52_3, complete sequence	132985-133011	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NZ_LT969519	Pseudomonas aeruginosa isolate RW109 genome assembly, plasmid: RW109 plasmid 1	455928-455954	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	LN997843	Streptomyces reticuli genome assembly TUE45, plasmid : II	579875-579901	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	MN013077	Klebsiella phage vB_KaeM_KaOmega, complete genome	11281-11307	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	KC954774	Cronobacter phage CR8, complete genome	11195-11221	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NC_028672	Cronobacter phage PBES 02, complete genome	65372-65398	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	NC_017974	Cronobacter phage CR3, complete genome	11202-11228	6	0.778
NC_010943_2	2.1\|332137\|27\|NC_010943\|CRISPRCasFinder	332137-332163	27	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	833762-833788	7	0.741
NC_010943_12	12.1\|3925032\|31\|NC_010943\|CRISPRCasFinder	3925032-3925062	31	NC_010879	Burkholderia glumae strain BGR1 plasmid pBGF2, complete sequence	12346-12376	8	0.742

1. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP014142 (Thermus parvatiensis strain RL plasmid pTP143, complete sequence) position: , mismatch: 2, identity: 0.926

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
gccgaggcccggcagtggcggcaggcg	Protospacer
*************.* ***********

2. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NC_017588 (Thermus thermophilus JL-18 plasmid pTTJL1801, complete sequence) position: , mismatch: 2, identity: 0.926

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
gccgaggcccggcagtggcggcaggcg	Protospacer
*************.* ***********

3. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NC_017273 (Thermus thermophilus SG0.5JP17-16 plasmid pTHTHE1601, complete sequence) position: , mismatch: 2, identity: 0.926

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
gccgaggcccggcagtggcggcaggcg	Protospacer
*************.* ***********

4. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_AP019795 (Thermus thermophilus strain AA2-29 plasmid pAA229, complete sequence) position: , mismatch: 2, identity: 0.926

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
gccgaggcccggcagtggcggcaggcg	Protospacer
*************.* ***********

5. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_LR027520 (Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence) position: , mismatch: 2, identity: 0.926

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
gccgaggcccggcagtggcggcaggcg	Protospacer
*************.* ***********

6. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_AP019793 (Thermus thermophilus strain AA2-20 plasmid pAA220, complete sequence) position: , mismatch: 2, identity: 0.926

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
gccgaggcccggcagtggcggcaggcg	Protospacer
*************.* ***********

7. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NC_016626 (Burkholderia sp. YI23 plasmid byi_1p, complete sequence) position: , mismatch: 3, identity: 0.889

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
gcgaaggcgcggcgggggcggcaggcg	Protospacer
** .**** ******************

8. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP021119 (Streptomyces sp. CLI2509 strain CLI2905 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.889

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
ggcgaggaccggcgggggcggcaggag	Protospacer
* ***** ***************** *

9. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 3, identity: 0.889

gccgaggcccggcgggggcggcaggcg-	CRISPR spacer
gccgaggccgggcgggggcgg-agccga	Protospacer
********* *********** ** **

10. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP022363 (Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence) position: , mismatch: 4, identity: 0.852

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
ggcgagggccggcggggtcggcaggcc	Protospacer
* ***** ********* ********

11. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 4, identity: 0.852

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
accgaggcccggcgccggcggcaggag	Protospacer
.*************  ********* *

12. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to KU996353 (UNVERIFIED: Streptomyces silaceus strain ACCC 40021 plasmid, complete sequence) position: , mismatch: 4, identity: 0.852

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
gtcggcgcccggcgggggcggcaggag	Protospacer
*.**. ******************* *

13. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP032344 (Azospirillum brasilense strain MTCC4038 plasmid p5, complete sequence) position: , mismatch: 4, identity: 0.852

gccgag--gcccggcgggggcggcaggcg	CRISPR spacer
--tgagccgcccggcgggggcggcacgcg	Protospacer
  .***  ***************** ***

14. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP033317 (Azospirillum brasilense strain Sp 7 plasmid p5, complete sequence) position: , mismatch: 4, identity: 0.852

gccgag--gcccggcgggggcggcaggcg	CRISPR spacer
--tgagccgcccggcgggggcggcacgcg	Protospacer
  .***  ***************** ***

15. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NC_013855 (Azospirillum sp. B510 plasmid pAB510a, complete sequence) position: , mismatch: 4, identity: 0.852

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
ggcaaggcccggcgggagcggccggcg	Protospacer
* *.************.***** ****

16. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP033323 (Azospirillum brasilense strain Cd plasmid p5, complete sequence) position: , mismatch: 4, identity: 0.852

gccgag--gcccggcgggggcggcaggcg	CRISPR spacer
--tgagccgcccggcgggggcggcacgcg	Protospacer
  .***  ***************** ***

17. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP012919 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p5, complete sequence) position: , mismatch: 4, identity: 0.852

gccgag--gcccggcgggggcggcaggcg	CRISPR spacer
--tgagccgcccggcgggggcggcacgcg	Protospacer
  .***  ***************** ***

18. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP012919 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p5, complete sequence) position: , mismatch: 4, identity: 0.852

gccgag--gcccggcgggggcggcaggcg	CRISPR spacer
--tgagccgcccggcgggggcggcacgcg	Protospacer
  .***  ***************** ***

19. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NC_009468 (Acidiphilium cryptum JF-5 plasmid pACRY02, complete sequence) position: , mismatch: 4, identity: 0.852

gccgag--gcccggcgggggcggcaggcg	CRISPR spacer
--cgggttgcccggcgggcgcggcaggcg	Protospacer
  **.*  ********** **********

20. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 5, identity: 0.815

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
agagcggcccggcggtggcggcaggcg	Protospacer
.  * ********** ***********

21. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP040820 (Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence) position: , mismatch: 5, identity: 0.815

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
gctgaggcccggcgggggcgacaaacc	Protospacer
**.*****************.**..*

22. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP025613 (Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
cccctggcccggcgggcgcggcaggcc	Protospacer
 **  *********** *********

23. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP048631 (Ancylobacter pratisalsi strain DSM 102029 plasmid pLGM, complete sequence) position: , mismatch: 5, identity: 0.815

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
accgaggcccggccggggcggcgagca	Protospacer
.************ ********..**.

24. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
cggcaggcccggcgggtgcggcaggca	Protospacer
    ************ *********.

25. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NC_016624 (Azospirillum lipoferum 4B plasmid AZO_p5, complete sequence) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
gccgaagcccggcgggggcggcttcgt	Protospacer
*****.****************

26. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP032054 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
cggcaggcccggcgggtgcggcaggca	Protospacer
    ************ *********.

27. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP016560 (Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
cggcaggcccggcgggtgcggcaggca	Protospacer
    ************ *********.

28. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP054625 (Cupriavidus gilardii strain FDAARGOS_639 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
cgcgcggcgcggcgggggcggcaggat	Protospacer
  ** *** ****************

29. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP054618 (Azospirillum oryzae strain KACC 14407 plasmid unnamed4, complete sequence) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
atcgcggcccgccgggggcggcaggtc	Protospacer
..** ****** *************.

30. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to MK059749 (Mycobacterium phage CRB2, complete genome) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
ctccaggcccggctggggcggcagggt	Protospacer
 .* ********* ***********

31. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_CP049031 (Fluviibacterium aquatile strain SC52 plasmid pSC52_3, complete sequence) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
tgcgaagcccggcgggggcggcatgtt	Protospacer
  ***.***************** *.

32. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NZ_LT969519 (Pseudomonas aeruginosa isolate RW109 genome assembly, plasmid: RW109 plasmid 1) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
cagcaggcccagcggggccggcaggcg	Protospacer
    ******.****** *********

33. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to LN997843 (Streptomyces reticuli genome assembly TUE45, plasmid : II) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
gccgaggcccggccggggcgggtcctg	Protospacer
************* *******    .*

34. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to MN013077 (Klebsiella phage vB_KaeM_KaOmega, complete genome) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
cagcaggcccggctggggcggcaggtg	Protospacer
    ********* ***********.*

35. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to KC954774 (Cronobacter phage CR8, complete genome) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
cagcaggcccggcgggggcagcaggtg	Protospacer
    ***************.*****.*

36. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NC_028672 (Cronobacter phage PBES 02, complete genome) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
ttgcaggcccggcgggggcagcaggtg	Protospacer
 .  ***************.*****.*

37. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to NC_017974 (Cronobacter phage CR3, complete genome) position: , mismatch: 6, identity: 0.778

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
cagcaggcccggcgggggcagcaggtg	Protospacer
    ***************.*****.*

38. spacer 2.1|332137|27|NC_010943|CRISPRCasFinder matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 7, identity: 0.741

gccgaggcccggcgggggcggcaggcg	CRISPR spacer
cgacaggcccggcgggcgcggcaggaa	Protospacer
    ************ ******** .

39. spacer 12.1|3925032|31|NC_010943|CRISPRCasFinder matches to NC_010879 (Burkholderia glumae strain BGR1 plasmid pBGF2, complete sequence) position: , mismatch: 8, identity: 0.742

cggtagatccgcgccatgcgtggatgggaaa	CRISPR spacer
cgtcagatccgcgccatccgcggatggctcg	Protospacer
** .************* **.******   .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

291568 : 345473

Stenotrophomonas_phage(85.37%)

portal,tRNA,holin,terminase,integrase,tail,capsid,head,plate

attL 286979:287003|attR 345512:345536

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
286979:287003	attL	NA	NA	NA	NA
WP_044569375.1\|291568_292600_+\|tRNA	tRNA dihydrouridine(20/20a) synthase DusA	NA	NA	NA	NA
WP_005407693.1\|292813_293188_+	hypothetical protein	NA	NA	NA	NA
WP_004136763.1\|293261_293945_+	response regulator transcription factor	NA	NA	NA	NA
WP_032953760.1\|293970_295395_+	sensor histidine kinase	NA	NA	NA	NA
WP_099470490.1\|295995_296787_-	zinc-dependent peptidase	NA	NA	NA	NA
WP_044569378.1\|296753_297032_-	hypothetical protein	NA	NA	NA	NA
WP_012478821.1\|297176_298145_+	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor	NA	NA	NA	NA
WP_005407698.1\|298141_298873_+	type III pantothenate kinase	NA	NA	NA	NA
WP_012478822.1\|298882_299731_+	SPOR domain-containing protein	NA	NA	NA	NA
WP_012478823.1\|299948_301127_-\|integrase	integrase	V9IQN0	Stenotrophomonas_phage	1.3e-201	86.9
WP_012478824.1\|301126_301351_-	hypothetical protein	V9IQX6	Stenotrophomonas_phage	5.9e-36	94.6
WP_012478826.1\|302178_302604_-	hypothetical protein	V9IQL6	Stenotrophomonas_phage	2.8e-58	87.2
WP_012478828.1\|302955_305652_-	toprim domain-containing protein	V9IQW5	Stenotrophomonas_phage	0.0e+00	84.1
WP_044569385.1\|305762_306023_-	hypothetical protein	V9IQH4	Stenotrophomonas_phage	3.7e-21	69.8
WP_087944440.1\|306022_306331_-	hypothetical protein	V9IQM8	Stenotrophomonas_phage	2.0e-18	50.5
WP_044569393.1\|306327_306570_-	hypothetical protein	V9IQX5	Stenotrophomonas_phage	2.3e-33	86.2
WP_012478830.1\|306893_307100_-	hypothetical protein	V9IQL4	Stenotrophomonas_phage	3.6e-24	88.2
WP_044569396.1\|307168_307513_-	ogr/Delta-like zinc finger family protein	V9IQW3	Stenotrophomonas_phage	2.7e-48	77.9
WP_012478832.1\|307509_307842_-	DNA-binding protein	NA	NA	NA	NA
WP_148272153.1\|307956_308343_+	XRE family transcriptional regulator	NA	NA	NA	NA
WP_049886002.1\|308668_309400_+	nucleotide-binding protein	NA	NA	NA	NA
WP_012478835.1\|309585_310977_+	DUF4935 domain-containing protein	NA	NA	NA	NA
WP_012478836.1\|310973_311966_-	phage late control D family protein	V9IQM7	Stenotrophomonas_phage	1.2e-128	74.1
WP_012478837.1\|311962_312361_-\|tail	phage tail protein	V9IQX3	Stenotrophomonas_phage	1.3e-62	91.7
WP_012478838.1\|312372_315237_-\|tail	phage tail tape measure protein	V9IQL1	Stenotrophomonas_phage	2.4e-283	64.1
WP_012478839.1\|315262_315379_-\|tail	GpE family phage tail protein	V9IQH2	Stenotrophomonas_phage	7.0e-09	86.5
WP_012478840.1\|315387_315714_-\|tail	phage tail assembly protein	V9IQM4	Stenotrophomonas_phage	4.3e-27	58.9
WP_012478841.1\|315769_316279_-\|tail	phage major tail tube protein	V9IQX1	Stenotrophomonas_phage	4.4e-87	94.7
WP_012478842.1\|316299_317469_-\|tail	phage tail sheath protein	E5FFG9	Burkholderia_phage	8.7e-147	66.6
WP_012478843.1\|317484_317835_-	GPW/gp25 family protein	V9IQW0	Stenotrophomonas_phage	5.8e-38	67.2
WP_012478844.1\|317831_318380_-\|plate	phage baseplate assembly protein V	V9IQH1	Stenotrophomonas_phage	9.1e-38	58.3
WP_012478845.1\|318466_318748_-	hypothetical protein	A0A088FV63	Escherichia_phage	5.5e-15	46.2
WP_012478846.1\|318757_319990_-\|tail	tail fiber protein	V9IQX0	Stenotrophomonas_phage	1.7e-55	47.7
WP_012478847.1\|319994_320546_-\|tail	phage tail protein I	V9IQK7	Stenotrophomonas_phage	1.6e-58	57.1
WP_012478848.1\|320538_321429_-\|plate	baseplate J/gp47 family protein	V9IQV9	Stenotrophomonas_phage	2.3e-107	64.9
WP_012478849.1\|321515_321977_-	phage virion morphogenesis protein	V9IQH0	Stenotrophomonas_phage	3.3e-57	75.2
WP_012478850.1\|321973_322459_-\|tail	phage tail protein	V9IQM0	Stenotrophomonas_phage	3.0e-53	68.5
WP_012478851.1\|322455_322980_-	hypothetical protein	V9IQW8	Stenotrophomonas_phage	1.1e-53	73.6
WP_012478852.1\|322979_323615_-	glycoside hydrolase family 19 protein	V9IQK6	Stenotrophomonas_phage	1.0e-77	87.5
WP_012478853.1\|323616_323892_-\|holin	phage holin family protein	V9IQV8	Stenotrophomonas_phage	2.2e-40	91.2
WP_012478854.1\|323884_324238_-	membrane protein	V9IQG9	Stenotrophomonas_phage	1.2e-51	94.0
WP_012478855.1\|324240_324456_-\|tail	tail protein X	V9IQL8	Stenotrophomonas_phage	1.1e-20	73.2
WP_012478856.1\|324455_324923_-\|head	head completion/stabilization protein	V9IQW6	Stenotrophomonas_phage	1.8e-55	75.5
WP_012478857.1\|325027_325735_-\|terminase	terminase	V9IQK3	Stenotrophomonas_phage	2.4e-59	72.7
WP_012478858.1\|325738_326755_-\|capsid	phage major capsid protein, P2 family	V9IQV7	Stenotrophomonas_phage	1.6e-149	79.5
WP_148272144.1\|326788_327703_-\|capsid	GPO family capsid scaffolding protein	V9IQG8	Stenotrophomonas_phage	1.5e-98	80.9
WP_044569400.1\|327806_329564_+\|terminase	terminase ATPase subunit family protein	V9IQL5	Stenotrophomonas_phage	0.0e+00	93.2
WP_012478861.1\|329563_330574_+\|portal	phage portal protein	V9IQW4	Stenotrophomonas_phage	2.8e-157	86.5
WP_080047722.1\|330576_330828_+	Com family DNA-binding transcriptional regulator	V9IQK2	Stenotrophomonas_phage	8.1e-34	85.2
WP_012478862.1\|330745_331456_+	site-specific DNA-methyltransferase	V9IQV5	Stenotrophomonas_phage	2.2e-129	93.6
WP_044569402.1\|331522_332011_-	hypothetical protein	NA	NA	NA	NA
WP_049886003.1\|332896_333241_+	hypothetical protein	NA	NA	NA	NA
WP_012478865.1\|333315_334077_-	NYN domain-containing protein	A4JWQ6	Burkholderia_virus	2.7e-80	60.7
WP_012478867.1\|334914_335202_-	hypothetical protein	NA	NA	NA	NA
WP_012478868.1\|335567_336692_-	hypothetical protein	NA	NA	NA	NA
WP_012478869.1\|336719_337319_-	hypothetical protein	NA	NA	NA	NA
WP_012478870.1\|337552_337840_+	type II toxin-antitoxin system RelE/ParE family toxin	A0A141GEX6	Brucella_phage	1.3e-19	45.3
WP_012478871.1\|337898_338201_+	putative addiction module antidote protein	A0A141GEX5	Brucella_phage	1.9e-08	39.3
WP_012478872.1\|338258_338582_-	hypothetical protein	NA	NA	NA	NA
WP_044569408.1\|338661_339069_-	hypothetical protein	NA	NA	NA	NA
WP_012478874.1\|339662_340433_+	DUF3011 domain-containing protein	NA	NA	NA	NA
WP_012478875.1\|340492_341437_+	ankyrin repeat domain-containing protein	NA	NA	NA	NA
WP_005407709.1\|341541_342462_+	arginase	A0A0N9R043	Chrysochromulina_ericina_virus	6.4e-28	33.6
WP_005407710.1\|342622_342760_+	entericidin A/B family lipoprotein	NA	NA	NA	NA
WP_004153772.1\|342967_343189_+	CsbD family protein	NA	NA	NA	NA
WP_012478876.1\|343262_344072_-	hypothetical protein	NA	NA	NA	NA
WP_012478877.1\|344180_345473_+\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
345512:345536	attR	NA	NA	NA	NA

DBSCAN-SWA_2

663604 : 674734

Enterobacteria_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012479083.1\|663604_664660_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	2.4e-79	46.2
WP_012479084.1\|664674_665562_+	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	9.7e-98	58.9
WP_012479085.1\|665558_666116_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	5.4e-46	51.1
WP_012479086.1\|666112_667018_+	dTDP-4-dehydrorhamnose reductase	A0A1D7XFA3	Escherichia_phage	4.1e-27	36.2
WP_143568537.1\|667210_668506_+	hypothetical protein	NA	NA	NA	NA
WP_012479088.1\|668558_669962_-	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	2.9e-40	28.1
WP_012479089.1\|669973_671320_-	phosphomannomutase/phosphoglucomutase	A0A127AWJ1	Bacillus_phage	2.2e-29	26.6
WP_012479090.1\|671416_674734_-	DEAD/DEAH box helicase	A0A0P0YNJ0	Yellowstone_lake_phycodnavirus	1.1e-45	34.7

DBSCAN-SWA_3

1036107 : 1150530

106

Escherichia_phage(17.86%)

plate,transposase,protease,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004154600.1\|1036107_1037397_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	2.9e-135	58.0
WP_012479268.1\|1037540_1039988_+	endopeptidase La	A0A0R6PGP8	Moraxella_phage	1.5e-220	52.0
WP_005408270.1\|1040205_1040478_+	HU family DNA-binding protein	A7KV42	Bacillus_phage	4.5e-22	62.9
WP_005408271.1\|1041318_1043274_+	peptidyl-prolyl cis-trans isomerase	NA	NA	NA	NA
WP_044569572.1\|1043486_1044686_-	lytic transglycosylase domain-containing protein	NA	NA	NA	NA
WP_012479270.1\|1044682_1045447_-	hydroxyacylglutathione hydrolase	NA	NA	NA	NA
WP_012479271.1\|1045458_1046109_+	hypothetical protein	NA	NA	NA	NA
WP_005408275.1\|1046122_1046575_+	ribonuclease HI	J9Q745	Salmonella_phage	1.0e-42	53.4
WP_012479272.1\|1046579_1047311_+	DNA polymerase III subunit epsilon	A0A1B2LRV5	Wolbachia_phage	3.8e-07	42.4
WP_005408277.1\|1047422_1048127_-	serine/threonine-protein phosphatase	NA	NA	NA	NA
WP_044569573.1\|1048789_1051801_-	autotransporter domain-containing protein	NA	NA	NA	NA
WP_005408281.1\|1052092_1052497_+	hypothetical protein	A0A1C9C5K8	Heterosigma_akashiwo_virus	1.3e-17	35.3
WP_012479274.1\|1052574_1053621_-	glycosyltransferase family 9 protein	NA	NA	NA	NA
WP_012479275.1\|1053641_1054391_+	3-deoxy-D-manno-octulosonic acid kinase	NA	NA	NA	NA
WP_005408284.1\|1054390_1055158_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_012479276.1\|1055154_1055544_+	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_005408286.1\|1056019_1056337_+	quaternary ammonium compound efflux SMR transporter SugE	NA	NA	NA	NA
WP_012479277.1\|1056695_1067600_+	autotransporter-associated beta strand repeat-containing protein	NA	NA	NA	NA
WP_012479278.1\|1067656_1068100_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_049442234.1\|1068859_1069990_-	hypothetical protein	NA	NA	NA	NA
WP_012479281.1\|1070067_1071207_-	DNA adenine methylase	NA	NA	NA	NA
WP_012479282.1\|1071792_1073826_+	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	2.1e-47	41.4
WP_005408298.1\|1073832_1074153_+	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_005408299.1\|1074264_1074864_+	recombination protein RecR	NA	NA	NA	NA
WP_005408300.1\|1074931_1075291_+	histidine triad nucleotide-binding protein	NA	NA	NA	NA
WP_005408301.1\|1075368_1075896_-	Slp family lipoprotein	NA	NA	NA	NA
WP_012479283.1\|1075892_1077842_-	DUF3488 domain-containing transglutaminase family protein	NA	NA	NA	NA
WP_043033683.1\|1077834_1078779_-	DUF58 domain-containing protein	NA	NA	NA	NA
WP_005408304.1\|1078781_1079735_-	AAA family ATPase	NA	NA	NA	NA
WP_012479285.1\|1079777_1081619_+	glycosyltransferase family 39 protein	NA	NA	NA	NA
WP_012479286.1\|1081848_1082418_-	septum formation inhibitor Maf	NA	NA	NA	NA
WP_012479287.1\|1082531_1083041_+	DUF177 domain-containing protein	NA	NA	NA	NA
WP_005408308.1\|1083148_1083343_+	50S ribosomal protein L32	NA	NA	NA	NA
WP_005408309.1\|1083434_1084412_+	ketoacyl-ACP synthase III	NA	NA	NA	NA
WP_005408310.1\|1084490_1085273_+	hypothetical protein	NA	NA	NA	NA
WP_012479288.1\|1085529_1086474_+	ACP S-malonyltransferase	NA	NA	NA	NA
WP_012479289.1\|1086556_1087300_+	3-oxoacyl-ACP reductase FabG	Q06VL0	Trichoplusia_ni_ascovirus	6.2e-13	32.3
WP_005408313.1\|1087452_1087692_+	acyl carrier protein	B2ZXV3	Ralstonia_phage	4.6e-10	44.6
WP_012479290.1\|1087835_1089098_+	beta-ketoacyl-ACP synthase II	NA	NA	NA	NA
WP_012479291.1\|1089312_1090677_+	aminodeoxychorismate synthase component I	NA	NA	NA	NA
WP_012479292.1\|1090874_1091936_+	endolytic transglycosylase MltG	NA	NA	NA	NA
WP_005412450.1\|1091932_1092598_+	dTMP kinase	W8D0J5	Erwinia_phage	5.5e-21	34.9
WP_012479293.1\|1092594_1093551_+	DNA polymerase III subunit delta'	NA	NA	NA	NA
WP_005412452.1\|1093547_1093901_+	PilZ domain-containing protein	NA	NA	NA	NA
WP_005408320.1\|1094320_1094701_+	tautomerase family protein	NA	NA	NA	NA
WP_049397149.1\|1094731_1095805_-\|tail	phage tail protein	D5LGY1	Escherichia_phage	2.5e-95	51.9
WP_005408322.1\|1095795_1096011_-\|tail	tail protein X	A0A193GYC8	Enterobacter_phage	1.6e-14	54.3
WP_005408323.1\|1095994_1096462_-\|tail	phage tail protein	A0A218M4I2	Erwinia_phage	1.1e-15	35.2
WP_012479295.1\|1096464_1098912_-\|tail	phage tail tape measure protein	A0A1W6JT50	Escherichia_phage	2.2e-27	22.7
WP_012479296.1\|1099032_1099323_-\|tail	phage tail assembly protein	A0A193GYZ8	Enterobacter_phage	5.5e-18	57.3
WP_012479297.1\|1099403_1099907_-\|tail	phage major tail tube protein	A0A193GYM4	Enterobacter_phage	5.2e-40	50.3
WP_012479298.1\|1099909_1101112_-\|tail	phage tail sheath subtilisin-like domain-containing protein	A0A088FVH5	Escherichia_phage	6.1e-127	54.2
WP_012479299.1\|1101218_1101878_-	hypothetical protein	V9IQM3	Stenotrophomonas_phage	6.2e-17	32.9
WP_012479300.1\|1101879_1103847_-\|tail	tail fiber domain-containing protein	V9IQX0	Stenotrophomonas_phage	1.8e-104	38.8
WP_012479301.1\|1103854_1104634_-\|tail	phage tail protein I	V9IQK7	Stenotrophomonas_phage	7.1e-44	51.1
WP_012479302.1\|1104626_1105523_-\|plate	baseplate J/gp47 family protein	V9IQV9	Stenotrophomonas_phage	1.9e-80	53.1
WP_005408332.1\|1105525_1105864_-	GPW/gp25 family protein	A0A193GYY8	Enterobacter_phage	7.8e-32	62.2
WP_012479303.1\|1105916_1106507_-\|plate	phage baseplate assembly protein V	A0A193GYL5	Enterobacter_phage	1.9e-25	38.2
WP_012479304.1\|1106503_1107058_-	hypothetical protein	NA	NA	NA	NA
WP_158079763.1\|1107183_1107327_+	hypothetical protein	NA	NA	NA	NA
WP_012479305.1\|1107411_1107789_-	hypothetical protein	NA	NA	NA	NA
WP_012479306.1\|1107785_1108271_-	glycoside hydrolase family 104 protein	D5LH07	Escherichia_phage	5.4e-42	55.6
WP_012479307.1\|1108267_1108618_-	hypothetical protein	NA	NA	NA	NA
WP_005408338.1\|1108614_1109064_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_005408339.1\|1109398_1109782_-	hypothetical protein	NA	NA	NA	NA
WP_012479309.1\|1109934_1110573_-	hypothetical protein	A0A2H4J8A1	uncultured_Caudovirales_phage	5.8e-20	38.8
WP_005412468.1\|1110614_1110842_-	hypothetical protein	NA	NA	NA	NA
WP_012479310.1\|1110916_1111192_-	hypothetical protein	NA	NA	NA	NA
WP_012479311.1\|1111192_1113529_-	toprim domain-containing protein	D5LH15	Escherichia_phage	3.7e-136	43.3
WP_005408344.1\|1114015_1114240_+	hypothetical protein	NA	NA	NA	NA
WP_012479313.1\|1114251_1114506_+	hypothetical protein	NA	NA	NA	NA
WP_005412471.1\|1114717_1115104_+	DUF2946 domain-containing protein	NA	NA	NA	NA
WP_012479315.1\|1115233_1117372_+	TonB-dependent receptor	NA	NA	NA	NA
WP_012479316.1\|1117383_1118889_+	PepSY domain-containing protein	NA	NA	NA	NA
WP_012479317.1\|1118898_1120032_-	MFS transporter	NA	NA	NA	NA
WP_012479318.1\|1120043_1120820_-	DeoR/GlpR transcriptional regulator	NA	NA	NA	NA
WP_044569588.1\|1120977_1121625_+	Qnr family pentapeptide repeat protein	NA	NA	NA	NA
WP_012479320.1\|1121628_1122303_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_044569589.1\|1122390_1123089_-	glutathione S-transferase family protein	NA	NA	NA	NA
WP_012479322.1\|1123204_1124149_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_012479323.1\|1124087_1125467_-	PLP-dependent aminotransferase family protein	NA	NA	NA	NA
WP_012479324.1\|1125600_1126464_+	DMT family transporter	NA	NA	NA	NA
WP_012479325.1\|1126503_1127439_-	LysR family transcriptional regulator	Q6JIH3	Burkholderia_virus	5.8e-08	21.2
WP_044569590.1\|1127546_1129064_+	MFS transporter	NA	NA	NA	NA
WP_033834825.1\|1129343_1129748_-	GFA family protein	NA	NA	NA	NA
WP_044569600.1\|1129919_1130897_+	DUF4105 domain-containing protein	NA	NA	NA	NA
WP_012479329.1\|1130893_1132915_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_012479330.1\|1133003_1134425_-	MFS transporter	NA	NA	NA	NA
WP_012479331.1\|1134454_1134889_+	redox-sensitive transcriptional activator SoxR	NA	NA	NA	NA
WP_012479332.1\|1134961_1135564_-	short chain dehydrogenase	NA	NA	NA	NA
WP_012479333.1\|1135662_1136538_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_012479334.1\|1136714_1137536_-	pyrroline-5-carboxylate reductase	NA	NA	NA	NA
WP_012479335.1\|1137554_1138232_-	YggS family pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_004147099.1\|1138319_1139357_+	type IV pilus twitching motility protein PilT	NA	NA	NA	NA
WP_005408369.1\|1139457_1140600_+	PilT/PilU family type 4a pilus ATPase	NA	NA	NA	NA
WP_005412488.1\|1140807_1141791_+	aldo/keto reductase	NA	NA	NA	NA
WP_005412489.1\|1141838_1142738_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_012479096.1\|1142966_1143881_-\|transposase	IS110-like element ISStma7 family transposase	Q75QL1	Wolbachia_phage	8.7e-25	33.8
WP_012479336.1\|1144286_1144499_+	DUF4287 domain-containing protein	NA	NA	NA	NA
WP_024956077.1\|1144609_1145317_+	YitT family protein	NA	NA	NA	NA
WP_012479338.1\|1145400_1145946_-	DNA-3-methyladenine glycosylase I	NA	NA	NA	NA
WP_044569607.1\|1145942_1147730_-	DUF4153 domain-containing protein	NA	NA	NA	NA
WP_005408377.1\|1147821_1148388_+	YqgE/AlgH family protein	NA	NA	NA	NA
WP_005408378.1\|1148380_1148875_+	Holliday junction resolvase RuvX	NA	NA	NA	NA
WP_005412492.1\|1148890_1149841_+	aspartate carbamoyltransferase catalytic subunit	NA	NA	NA	NA
WP_005408380.1\|1150038_1150530_+\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_4

1896445 : 1938041

Acidithiobacillus_phage(37.84%)

portal,tRNA,terminase,capsid,tail,head,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_087944428.1\|1896445_1897586_+\|transposase	IS3-like element ISStma9 family transposase	U5P429	Shigella_phage	7.4e-90	60.6
WP_148272145.1\|1897698_1898142_+	hypothetical protein	NA	NA	NA	NA
WP_012479804.1\|1898134_1899376_+	AAA family ATPase	NA	NA	NA	NA
WP_148272146.1\|1899863_1900670_+	hypothetical protein	NA	NA	NA	NA
WP_012479806.1\|1900666_1901125_-	hypothetical protein	NA	NA	NA	NA
WP_080047724.1\|1901197_1901437_-	glycoside hydrolase family protein	K4I410	Acidithiobacillus_phage	2.0e-18	77.0
WP_012479807.1\|1901438_1901939_-	hypothetical protein	A0A077K9R7	Ralstonia_phage	1.7e-27	50.0
WP_012479808.1\|1901935_1902439_-	lysozyme	A0A0A8KXN5	Burkholderia_phage	2.3e-19	40.6
WP_044569883.1\|1902435_1902663_-	hypothetical protein	NA	NA	NA	NA
WP_012479809.1\|1902659_1902962_-	hypothetical protein	K4I011	Acidithiobacillus_phage	7.0e-24	70.2
WP_012479810.1\|1903025_1903376_-	DUF2793 domain-containing protein	A0A172PZV5	Pseudomonas_phage	2.4e-36	62.9
WP_012479811.1\|1903375_1905649_-\|tail	tail assembly protein	A0A1L2C8W7	Pseudomonas_phage	4.2e-137	38.8
WP_012479812.1\|1905648_1905861_-	hypothetical protein	A0A1X9IAJ5	Xanthomonas_phage	9.6e-12	54.8
WP_009518720.1\|1905857_1906085_-	hypothetical protein	A0A2K8HRJ9	Pseudomonas_phage	2.5e-10	65.9
WP_012479813.1\|1906104_1906893_-	phage BR0599 family protein	A0A0A1IX16	Pseudomonas_phage	1.5e-28	33.1
WP_044569890.1\|1906895_1908458_-	hypothetical protein	NA	NA	NA	NA
WP_012479815.1\|1908454_1909513_-	hypothetical protein	K4JSI9	Caulobacter_virus	2.0e-09	24.4
WP_012479816.1\|1909518_1912215_-\|tail	tail protein	A0A0F7L9V3	uncultured_marine_virus	4.7e-26	35.3
WP_012479817.1\|1912214_1912856_-	hypothetical protein	NA	NA	NA	NA
WP_153305628.1\|1912860_1913019_-	hypothetical protein	NA	NA	NA	NA
WP_044569892.1\|1913045_1913435_-	hypothetical protein	NA	NA	NA	NA
WP_012479819.1\|1913446_1914199_-	hypothetical protein	A0A2D2W2E0	Stenotrophomonas_phage	2.7e-56	49.6
WP_012479820.1\|1914201_1914390_-	hypothetical protein	NA	NA	NA	NA
WP_044569895.1\|1914397_1914823_-	hypothetical protein	F4YCS3	Synechococcus_phage	6.9e-09	28.8
WP_044571268.1\|1914833_1915115_-	hypothetical protein	NA	NA	NA	NA
WP_012479822.1\|1915117_1916122_-\|capsid	major capsid protein	Q9JMM2	Wolbachia_phage	7.3e-142	71.4
WP_012479823.1\|1916124_1916502_-\|head	head decoration protein	A0A1B2LRT0	Wolbachia_phage	6.9e-29	54.0
WP_012479824.1\|1916503_1917712_-	S49 family peptidase	K4HZZ6	Acidithiobacillus_phage	3.2e-67	40.9
WP_012479825.1\|1917722_1919210_-\|portal	phage portal protein	A0A1B2LRR5	Wolbachia_phage	1.8e-149	56.6
WP_012479826.1\|1919211_1919433_-	hypothetical protein	A0A2H4JCJ9	uncultured_Caudovirales_phage	5.3e-13	57.5
WP_012479827.1\|1919432_1919825_-	hypothetical protein	NA	NA	NA	NA
WP_012479828.1\|1919824_1920313_-	hypothetical protein	A0A0F6WCR7	Sinorhizobium_phage	7.1e-26	47.7
WP_044569900.1\|1920324_1922274_-\|terminase	phage terminase large subunit family protein	A0A2H4JIC6	uncultured_Caudovirales_phage	0.0e+00	87.7
WP_012479830.1\|1922350_1922935_-	hypothetical protein	A0A2H4JCL4	uncultured_Caudovirales_phage	9.4e-49	56.7
WP_012479831.1\|1923045_1923252_+	hypothetical protein	NA	NA	NA	NA
WP_012479832.1\|1923358_1923877_+	DUF3489 domain-containing protein	A0A2H4JE21	uncultured_Caudovirales_phage	6.6e-30	72.0
WP_012479833.1\|1923972_1924338_+	hypothetical protein	A0A2H4JI44	uncultured_Caudovirales_phage	1.8e-53	81.5
WP_044569905.1\|1924337_1924544_+	hypothetical protein	NA	NA	NA	NA
WP_087944431.1\|1924747_1926320_+\|transposase	IS3 family transposase	Q6J1X2	Lactobacillus_phage	5.1e-09	30.5
WP_148272147.1\|1926511_1926910_+	hypothetical protein	NA	NA	NA	NA
WP_012479837.1\|1926923_1928171_-	site-specific DNA-methyltransferase	A0A2H4JGF1	uncultured_Caudovirales_phage	2.8e-215	88.2
WP_044569908.1\|1928167_1929583_-	site-specific DNA-methyltransferase	K4I3Y2	Acidithiobacillus_phage	6.2e-171	62.8
WP_044569912.1\|1929929_1930358_-	hypothetical protein	NA	NA	NA	NA
WP_012479840.1\|1930350_1930560_-	hypothetical protein	NA	NA	NA	NA
WP_012479841.1\|1930561_1931038_-	hypothetical protein	K4ICN3	Acidithiobacillus_phage	3.8e-64	77.5
WP_012479842.1\|1931169_1933470_-	hypothetical protein	K4HZY1	Acidithiobacillus_phage	0.0e+00	72.4
WP_012479843.1\|1933466_1933721_-	hypothetical protein	K4I1D6	Acidithiobacillus_phage	4.4e-19	69.1
WP_012479844.1\|1933717_1934455_-\|tRNA	isoleucyl-tRNA synthetase	K4HZA0	Acidithiobacillus_phage	3.0e-108	75.4
WP_044571296.1\|1934465_1934942_-	hypothetical protein	K4I3X7	Acidithiobacillus_phage	5.1e-61	70.7
WP_012479846.1\|1935021_1935663_-	hypothetical protein	K4ICM8	Acidithiobacillus_phage	6.6e-80	70.2
WP_044569915.1\|1935668_1936523_-	ATP-binding protein	K4HZX9	Acidithiobacillus_phage	7.6e-108	69.9
WP_012479848.1\|1936522_1937284_-	hypothetical protein	K4I1D2	Acidithiobacillus_phage	3.0e-87	67.5
WP_044569917.1\|1937289_1937766_-	hypothetical protein	K4HZ96	Acidithiobacillus_phage	1.5e-52	65.2
WP_012479850.1\|1937777_1938041_-	hypothetical protein	K4I3X3	Acidithiobacillus_phage	2.3e-23	60.9

DBSCAN-SWA_5

1941863 : 1950516

Acidithiobacillus_phage(62.5%)

integrase

attL 1942717:1942731|attR 1951527:1951541

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_044569920.1\|1941863_1942055_+	hypothetical protein	K4HZ94	Acidithiobacillus_phage	2.6e-16	79.4
WP_012479855.1\|1942054_1942510_+	DUF2924 domain-containing protein	K4I3X1	Acidithiobacillus_phage	4.6e-51	66.0
WP_012479856.1\|1942506_1943877_+	recombinase family protein	K4ICM1	Acidithiobacillus_phage	1.0e-207	78.0
1942717:1942731	attL	NA	NA	NA	NA
WP_012479857.1\|1943873_1944242_+	hypothetical protein	K4HZX2	Acidithiobacillus_phage	2.0e-41	70.8
WP_012479858.1\|1944253_1944733_+	hypothetical protein	K4I1C7	Acidithiobacillus_phage	8.2e-27	42.0
WP_099497841.1\|1945570_1946305_+	hypothetical protein	NA	NA	NA	NA
WP_012479860.1\|1946294_1947431_+	ImmA/IrrE family metallo-endopeptidase	A0A0A7RTT7	Clostridium_phage	5.5e-29	27.9
WP_005409154.1\|1947487_1948663_-\|integrase	site-specific integrase	A0A1W6JTA0	Pseudomonas_phage	1.2e-90	48.5
WP_005409155.1\|1948605_1948884_-	hypothetical protein	NA	NA	NA	NA
WP_005409158.1\|1949459_1949687_+	hypothetical protein	NA	NA	NA	NA
WP_005409159.1\|1949778_1950516_-	hypothetical protein	A0A249XQ08	Mycobacterium_phage	5.3e-25	33.0
1951527:1951541	attR	NA	NA	NA	NA

DBSCAN-SWA_6

2446088 : 2508751

uncultured_Caudovirales_phage(45.45%)

transposase,integrase

attL 2444491:2444506|attR 2510845:2510860

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2444491:2444506	attL	NA	NA	NA	NA
WP_012480192.1\|2446088_2447429_-\|transposase	ISL3-like element ISStma11 family transposase	A0A2D1GQC1	Lysinibacillus_phage	7.8e-75	38.9
WP_087944433.1\|2448184_2449307_+\|transposase	IS3-like element ISStma13 family transposase	S5WIU1	Leptospira_phage	7.6e-47	40.4
WP_012480196.1\|2449349_2450396_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_012480197.1\|2450459_2450807_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012480198.1\|2450838_2452062_-	MFS transporter	NA	NA	NA	NA
WP_012480199.1\|2452092_2452512_-	arsenate reductase (glutaredoxin)	A0A2H4J8T1	uncultured_Caudovirales_phage	3.6e-42	63.7
WP_012480200.1\|2452508_2453249_-	arsenical resistance protein ArsH	A0A2H4J5V6	uncultured_Caudovirales_phage	4.3e-83	68.5
WP_012480201.1\|2453290_2453605_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012480202.1\|2453632_2454124_+	arsenate reductase ArsC	A0A2H4J8A6	uncultured_Caudovirales_phage	1.1e-23	41.7
WP_012480203.1\|2454144_2455203_+	ACR3 family arsenite efflux transporter	NA	NA	NA	NA
WP_012480204.1\|2455206_2456193_+	thioredoxin-disulfide reductase	A0A2I2L5E1	Orpheovirus	1.0e-63	44.7
WP_026070021.1\|2456217_2457291_+	NAD(P)/FAD-dependent oxidoreductase	A0A2H4J2Q2	uncultured_Caudovirales_phage	3.8e-88	58.7
WP_012480206.1\|2457541_2457985_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012480207.1\|2458228_2458624_+	hypothetical protein	NA	NA	NA	NA
WP_012480208.1\|2458697_2460002_+	TolC family protein	NA	NA	NA	NA
WP_012480209.1\|2459998_2461513_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_005413407.1\|2461509_2464650_+	efflux RND transporter permease subunit	NA	NA	NA	NA
WP_012480210.1\|2464754_2465585_-	DUF4198 domain-containing protein	NA	NA	NA	NA
WP_005995736.1\|2465611_2466001_-	TonB-dependent receptor	NA	NA	NA	NA
WP_005413410.1\|2465969_2466176_+	arginase family protein	NA	NA	NA	NA
WP_005995733.1\|2466205_2466757_-	DUF305 domain-containing protein	NA	NA	NA	NA
WP_005413412.1\|2466831_2467107_-	hypothetical protein	NA	NA	NA	NA
WP_100437323.1\|2467135_2469220_-	copper-translocating P-type ATPase	A0A218MNH6	uncultured_virus	2.8e-87	35.2
WP_012480212.1\|2469518_2470460_-	copper homeostasis membrane protein CopD	NA	NA	NA	NA
WP_005413416.1\|2470470_2470854_-	copper homeostasis periplasmic binding protein CopC	NA	NA	NA	NA
WP_012480213.1\|2471032_2471383_-	four-helix bundle copper-binding protein	NA	NA	NA	NA
WP_019184727.1\|2471453_2471819_-	DUF411 domain-containing protein	NA	NA	NA	NA
WP_005995720.1\|2471992_2472547_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_019184728.1\|2472521_2473274_-	cytochrome c	NA	NA	NA	NA
WP_005413421.1\|2473304_2474573_-	copper-binding protein CopB	NA	NA	NA	NA
WP_012480217.1\|2474569_2476438_-	copper resistance system multicopper oxidase	NA	NA	NA	NA
WP_012480218.1\|2476551_2476971_-	transcriptional regulator CopL	NA	NA	NA	NA
WP_043033515.1\|2477145_2477496_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012480222.1\|2478398_2479451_-	DNA-binding protein	NA	NA	NA	NA
WP_012480223.1\|2479725_2481306_+	AAA family ATPase	NA	NA	NA	NA
WP_012480224.1\|2481283_2482381_+	AAA family ATPase	NA	NA	NA	NA
WP_019184735.1\|2482396_2482672_-	hypothetical protein	NA	NA	NA	NA
WP_019184736.1\|2482668_2485860_-	CusA/CzcA family heavy metal efflux RND transporter	NA	NA	NA	NA
WP_012480226.1\|2485868_2486819_-	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_012480227.1\|2486815_2488093_-	TolC family protein	NA	NA	NA	NA
WP_012480228.1\|2488148_2488505_-	hypothetical protein	NA	NA	NA	NA
WP_005413376.1\|2488501_2489119_-	cation transporter	NA	NA	NA	NA
WP_012480229.1\|2489143_2491102_-	FTR1 family protein	NA	NA	NA	NA
WP_012480230.1\|2491192_2491606_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_005413373.1\|2491602_2492874_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012480231.1\|2492898_2495892_+\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	2.4e-76	26.4
WP_012480232.1\|2496035_2496236_-	hypothetical protein	NA	NA	NA	NA
WP_012480233.1\|2496679_2497138_+	hypothetical protein	NA	NA	NA	NA
WP_012480234.1\|2497188_2499114_-	DUF4209 domain-containing protein	NA	NA	NA	NA
WP_012480235.1\|2499091_2499565_-	hypothetical protein	NA	NA	NA	NA
WP_012480236.1\|2499551_2499989_-	hypothetical protein	NA	NA	NA	NA
WP_012480237.1\|2499985_2500930_-	DNA-binding protein	NA	NA	NA	NA
WP_044570177.1\|2501035_2502115_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_012480239.1\|2502268_2505232_+	hypothetical protein	NA	NA	NA	NA
WP_080047726.1\|2505233_2505848_-	WYL domain-containing protein	NA	NA	NA	NA
WP_080047727.1\|2506008_2506545_+	DUF1508 domain-containing protein	A0A2P1N580	Mycobacterium_phage	6.9e-06	57.5
WP_012480241.1\|2506713_2507349_+	hypothetical protein	A0A2H4J137	uncultured_Caudovirales_phage	5.6e-47	45.4
WP_148272149.1\|2507345_2507621_+	hypothetical protein	NA	NA	NA	NA
WP_087944427.1\|2507594_2508751_-\|transposase	IS3-like element ISStma5 family transposase	NA	NA	NA	NA
2510845:2510860	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_010943

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection