CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014012	Shewanella violacea DSS12, complete genome	13 crisprs	csa3,DEDDh,cas3,WYL,DinG	0	3	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014012_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_1

25481-25638

Orphan

Consensus_repeat	Method
AGTGACCTTCTTTTCTTAAGATCTGGATTCCGGCCAAGAGCATGCCGGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014012_1

>merge|NC_014012|1|25481-25638|CRISPRCasFinder
AGTGACCTTCTTTTCTTAAGATCTGGATTCCGGCCAAGAGCATGCCGGAATGACTAAAGTGGGTGAGATCGAGATTAGTGACTAGAAACTAAGATCTTTAATTAGCGCAGTGACCTTCTTTTCTTAAGATCTGGATTCCGGCCAAGAGCATGCCGGAA

>NC_014012|1|1|25481-25638|CRISPRCasFinder
AGTGACCTTCTTTTCTTAAGATCTGGATTCCGGCCAAGAGCATGCCGGAA	TGACTAAAGTGGGTGAGATCGAGATTAGTGACTAGAAACTAAGATCTTTAATTAGCGC
AGTGACCTTCTTTTCTTAAGATCTGGATTCCGGCCAAGAGCATGCCGGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_013049309.1\|19973_20978_+\|5'/3'-nucleotidase-SurE	unknown	unknown	gnl\|CDD\|376695
NC_014012.1\|WP_013049302.1\|12697_12949_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|171099
NC_014012.1\|WP_157608638.1\|19430_19601_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013049313.1\|25903_27265_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NC_014012.1\|WP_013049315.1\|29025_29283_-\|membrane-protein-insertion-efficiency-factor-YidD	unknown	unknown	gnl\|CDD\|376620
NC_014012.1\|WP_013049310.1\|20993_21665_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_041419527.1\|11473_12403_+\|DUF1186-domain-containing-protein	unknown	unknown	gnl\|CDD\|200353
NC_014012.1\|WP_041419529.1\|37105_37528_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013049320.1\|34209_36630_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	unknown	unknown	gnl\|CDD\|237860
NC_014012.1\|WP_013049317.1\|30204_31593_+\|chromosomal-replication-initiator-protein-DnaA	unknown	unknown	gnl\|CDD\|273037
NC_014012.1\|WP_013049305.1\|17007_18105_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NC_014012.1\|WP_013049306.1\|18467_18692_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_006083827.1\|29620_29758_-\|50S-ribosomal-protein-L34	unknown	unknown	gnl\|CDD\|366117
NC_014012.1\|WP_041420145.1\|13342_16504_-\|DUF3427-domain-containing-protein	unknown	unknown	gnl\|CDD\|197297
NC_014012.1\|WP_013049301.1\|12413_12698_-\|Txe/YoeB-family-addiction-module-toxin	unknown	unknown	gnl\|CDD\|284238
NC_014012.1\|WP_013049319.1\|33110_34208_+\|DNA-replication/repair-protein-RecF	unknown	unknown	gnl\|CDD\|234608
NC_014012.1\|WP_013049316.1\|29249_29606_-\|ribonuclease-P-protein-component	unknown	unknown	gnl\|CDD\|179327
NC_014012.1\|WP_049791009.1\|22135_24703_+\|ATP-dependent-RNA-helicase	unknown	unknown	gnl\|CDD\|224557
NC_014012.1\|WP_013049314.1\|27387_29022_-\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|234942
NC_014012.1\|WP_013049318.1\|31612_32713_+\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|235541

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_013049309.1\|19973_20978_+\|5'/3'-nucleotidase-SurE	gnl\|CDD\|376695	pfam01975, SurE, Survival protein SurE. E. coli cells with the surE gene disrupted are found to survive poorly in stationary phase. It is suggested that SurE may be involved in stress response. Yeast also contains a member of the family. Yarrowia lipolytica PHO2 can complement a mutation in acid phosphatase, suggesting that members of this family could be phosphatases.	4.6831e-39
NC_014012.1\|WP_013049302.1\|12697_12949_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|171099	PRK11409, PRK11409, YoeB-YefM toxin-antitoxin system antitoxin YefM.	1.14797e-18
NC_014012.1\|WP_013049318.1\|31612_32713_+\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|235541	PRK05643, PRK05643, DNA polymerase III subunit beta; Validated.	0
NC_014012.1\|WP_013049313.1\|25903_27265_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NC_014012.1\|WP_013049315.1\|29025_29283_-\|membrane-protein-insertion-efficiency-factor-YidD	gnl\|CDD\|376620	pfam01809, Haemolytic, Haemolytic domain. This domain has haemolytic activity. It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.	2.87977e-35
NC_014012.1\|WP_041419527.1\|11473_12403_+\|DUF1186-domain-containing-protein	gnl\|CDD\|200353	TIGR04102, SEC-C_motif_domain_protein, SWIM/SEC-C metal-binding motif protein, PBPRA1643 family. Members of this protein family have a SWIM, or SEC-C, domain (see pfam02810), a 21-amino acid putative Zn-binding domain that is shared with SecA, plant MuDR transposases, etc. This small protein family of unknown function occurs primarily in marine bacteria.	2.17329e-12
NC_014012.1\|WP_013049320.1\|34209_36630_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	gnl\|CDD\|237860	PRK14939, gyrB, DNA gyrase subunit B; Provisional.	0
NC_014012.1\|WP_013049305.1\|17007_18105_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	5.2457e-67
NC_014012.1\|WP_013049317.1\|30204_31593_+\|chromosomal-replication-initiator-protein-DnaA	gnl\|CDD\|273037	TIGR00362, DnaA, chromosomal replication initiator protein DnaA. DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair].	0
NC_014012.1\|WP_006083827.1\|29620_29758_-\|50S-ribosomal-protein-L34	gnl\|CDD\|366117	pfam00468, Ribosomal_L34, Ribosomal protein L34.	6.18601e-12
NC_014012.1\|WP_041420145.1\|13342_16504_-\|DUF3427-domain-containing-protein	gnl\|CDD\|197297	cd09203, PLDc_N_DEXD_b1, N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain. N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain. All members of this subfamily are uncharacterized. Other characterized members of the superfamily that have a related domain architecture ( containing a DEAD/DEAH box helicase domain), include the DNA/RNA helicase superfamily II (SF2) and Res-subunit of type III restriction endonucleases. In addition to the helicase-like region, members of this subfamily also contain one copy of the conserved HKD motif (H-x-K-x(4)-D, where x represents any amino acid residue) in the N-terminal putative catalytic domain. The HKD motif characterizes the phospholipase D (PLD, EC 3.1.4.4) superfamily.	2.58155e-77
NC_014012.1\|WP_013049301.1\|12413_12698_-\|Txe/YoeB-family-addiction-module-toxin	gnl\|CDD\|284238	pfam06769, YoeB_toxin, YoeB-like toxin of bacterial type II toxin-antitoxin system. YoeB_toxin is a family of bacterial toxins that forms one component of the type II toxin-antitoxin system in E. coli whose antitoxin is represented by YefM, found in pfam02604. The plasmid encoded Axe-Txe proteins in Enterococcus faecium act as an antitoxin-toxin pair. When the plasmid is lost, the antitoxin is degraded relatively quickly by host enzymes. This allows the toxin to interact with its intracellular target, thus killing the cell or impeding cell growth. These toxins are highly potent protein synthesis inhibitors, specifically blocking the initiation of translation. In the case of YoeB, it binds to the 50 S ribosomal subunit in 70 S ribosomes and interacts with the A site leading to mRNA cleavage at this site. As a result, the 3'-end portion of the mRNA is released from ribosomes, and translation initiation is effectively inhibited.	3.14848e-45
NC_014012.1\|WP_013049316.1\|29249_29606_-\|ribonuclease-P-protein-component	gnl\|CDD\|179327	PRK01732, rnpA, ribonuclease P; Reviewed.	2.67392e-66
NC_014012.1\|WP_049791009.1\|22135_24703_+\|ATP-dependent-RNA-helicase	gnl\|CDD\|224557	COG1643, HrpA, HrpA-like helicases [DNA replication, recombination, and repair].	2.74557e-111
NC_014012.1\|WP_013049314.1\|27387_29022_-\|membrane-protein-insertase-YidC	gnl\|CDD\|234942	PRK01318, PRK01318, membrane protein insertase; Provisional.	0
NC_014012.1\|WP_013049319.1\|33110_34208_+\|DNA-replication/repair-protein-RecF	gnl\|CDD\|234608	PRK00064, recF, recombination protein F; Reviewed.	1.06866e-122

>NC_014012.1|WP_049791009.1|22135_24703_+|ATP-dependent-RNA-helicase
MQPTTPKSYVSEPSNKITSSINSLPIDKLYDEFKLAIKDNHLVVESDTGSGKSTRLPLWCVEAGCVEAGNVEPKEGDRPKRVLVVEPRRVACLALSSFVSTQTELKVGHSIRFDSTVTDDTQVAFVTPGIALRWLQETGLASFTTVIIDEFHERRWDTDLLLAMLKLKALSSPEFRLILTSATIDGERLTRYLGKTAGRLVAEGKRFHVELKYQASESHHLPDIRGVEQGVKTAVSGLLQQTDGDILVFLPGKREIQGAIQICQPLVLASGKPLELLALHGGISPVEQKKILQQAEHQRIIFATNVAETSLTIPGVTAVVDSGLERRTHQRNGRTVLSLARISKASCAQRMGRAGRTQNGICIRLWGQSAPMEAMTPPELQREELVEPMLAAACCGYKLSELEFVDDLPVKSLAIAEQKLLAMGAIDADGQITPHGKKLSPLPIDTQFAHLISAMPDDTCRGLMVDLAAALSVPHGLFKLPTSEFDLKLLSEWEPLGCDAFTLIKIVRDKLPDFLADADAGYVHKGARKEARMLAAQIRSALGLQTIEQSDALASKDIELRQRWLLAVIKAAPELAYVRREKRITALGNGFSEAQIGRVSRFCSEIKTVDGKESALAAVIFDLHSIAGKGAKQTLNLASCMAPISFDLLLEAKLGEERLGDSKEKGQSHKLVVDTFYAGRVIGSRLKQVEGEQAIEAIVRSISVGRQFKGLSQRLKNDIAAWNIWLALGKAKEQFTESGLVNSLGEEPLVFDVYLMERLNELGVESFDDLQLIEADDLLFEGIPDWQREEFDTLYPTKLILADLKLNVEYLPKRKLVTLVYANGSRKTGPKRWELPRWQGWKIQYKKASRVVDVK
>NC_014012.1|WP_013049310.1|20993_21665_+|hypothetical-protein
MKKCFIGLVSLAFLAACSSDDSNKVPQVSGIFSGVTYSEAGAPLKVTATAINLAGSDQTAFTTIVTLWDERDQQISYSGIYHQDSNKLTFANEKYECIPDNNLWLCSSAVESFTLAKVTPEAVSIDLVLGSYSAQLGSDSYGLVIAADNKFTILSAGCEANGSLSYELDGQVLMFELADKTLEDTCGLDNLTGIINYVSDNDELFSLEFQTVNSDIPITWLKR
>NC_014012.1|WP_013049309.1|19973_20978_+|5'/3'-nucleotidase-SurE
MKIKTGLLSALIAQALLVSAPAAALNIVLTNDDSWNTHNIKAMKEALVAKGHDVIMAAPCTGQSGKGGSFGFFKSVKVDETKAEQYEFCIGDLDTSQSFEDYVEGTPVMSVLYGIDVAAQKKWGKAPDLVVSGPNEGNNLGYMNNNSGTLGATMIALSRGIPAIAVSASENSLSDATQGPKIASVVVNVIDKLEASRADNQPLLPAYMGLNINTPEDIDASLGYRFTDVGWNGGGIALKFVEDFSDNEMIVGYFAQILLAQGAAESMEQALAMAKGMLQGKQGVGFALSDVNDSNENSEGVAVKNGYITISTIDASVQATRAKRALTQQRLSGL
>NC_014012.1|WP_157608638.1|19430_19601_-|hypothetical-protein
MAAWLYLCLLLAAGFSADTSARRRKHFHVGSTKTSMFWKLAAVSTPVGKAELTSSI
>NC_014012.1|WP_013049306.1|18467_18692_+|hypothetical-protein
MHAGNMQDHIQHLLQAINTNIAMLPNTLPSKKPAQRSQQTNQQGYLPHLLADKSQHRVYVSWLLPAVFIFCIYN
>NC_014012.1|WP_013049305.1|17007_18105_-|Fic-family-protein
MWIWQQANWPDFRWETDNIALLLRQVRFNQGLLLGKLDSEPSAQMTLDTLLANIIHSSAIEGEKLNAFSVRSSLANKLGISDEKPYPTTVQTDGLAEMTLDALQNWQTELSLQRIMDWHKLLFPEGYTLFNPVQGGVLRGSEPMQVISGRIDKPKVHFEAPPRSGLEDELTRFIDWFNRSQQDVAMDPLIRAAITHLWFVTLHPLDDGNGRITRLLTDLALAQAESRSIHFYAMSVSILERRQAYYDILESTQKGELDITSWLVWFLDTLNSSLQKSLDDIAQTVAKTNYWQRVDQTLLSGEQVKVLNRLLNGEFELGISSSQYQKVAKVSRATATRHLAQLVEQSFLVKAGAGGRSTRYLLASK
>NC_014012.1|WP_041420145.1|13342_16504_-|DUF3427-domain-containing-protein
MMQTGIYEQLITKVISNKLDKDKFFISERNMDTTEQTLWLTRALVHVFHLAISESKNTKDSPLAQIELANELIYWLQERIENLDLSDYTIAQPAKLLTAIFDKQDPVSAKLSAHIDKITPLTGLTQSELFCGSNQGISLESEIKREILSSNKICWIISFIKWTGLRIFMDELRTFTSNNKHKLQIITTSYMGATDLKAVQWLAKLPNTEVKLSYNHNQERLHAKSYLFMRDSGFHTAYIGSSNLSRSALTNGLEWNLKITNQEIPHIIDKTFSTFETYWQQPEFDFFDGSEKASSKLNRSLNLGRGDKNNSNTVFFDLAPHQHQIEILERLDAERNLHGRNRNLIVAATGTGKTLISAFDFKRFYQENPTAKILFIAHREEILKQAIESFRAVLKQPNFGELWVGQHKPDSYDQLFASIQTFNNQLDNMNLSSDYYDFIVIDEVHHVSAESYRKFISYFSPKILLGLTATPERHDGKNILDDFGGVIAAELRLPEAINLRYLCPFQYFGIDDNTDLRQVKWENGRYNPSELTQVYTQNDQRLQKILQNIEELVTNPLEMRALAFCVNQDHARYMAEKFCLKGIPSAVLTSKNASERHSVRQDLQLGNINILCVVDIFNEGVDIPEIDTLLFLRPTESLTIFLQQLGRGLRHNDGKECVTVLDFVGNARTEYDFSQKFRALIGKTHTAISKEIEHGFPHLPLGCHIELQKKTKEIILNNIKQAILNQQKLKSHIQNFQHHTVQKLTLSNFLNFYPNIRLIDIYKKKPKDGGGWTRLLSDLLLIPRVNETTIAENYHRAIFNSIIKCDARTYLKFIRSLAINHFKWVDNGDAIEQRMALMCHYDFWSCSGDKLGFTSLSESLAALTHPEYQNELIEVINYLLDNNDTQVQRLQTDFPCPLQLNARYTREQIIAGLGGSSFEKQAVSREGVFNLRELNVELLFVTLQKSDQHFSPTTLYHDYAMSPTHFHWQTQNSARPDSGKGLAYIQHKDIGKKLMLWVRESNKDENGNTMGFVNLGWVNLAETSGSQPMNITWELHEPMPSYLWKDAAKLANS
>NC_014012.1|WP_013049302.1|12697_12949_-|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MSVYSFTEVRSNFKSVCDSVVNDCEPAVIHRRGAENVVMFSESEFNSWKETIYLLSNPVNAKHLLDSIKQIDDGQAQERELLD
>NC_014012.1|WP_013049301.1|12413_12698_-|Txe/YoeB-family-addiction-module-toxin
MKTNTTTLFSTFYSEQAWNDYLYWQQQDKKTLKRINLLIKDCQRTPFEGIGKPERLKENLSGYWSRRISDEHRLVYRANQDQLTIVALRFHYSS
>NC_014012.1|WP_041419527.1|11473_12403_+|DUF1186-domain-containing-protein
MKLDEIVTTLSRGDLKELPVDALLAARLQWSELLPVIEALMQKFIVKEALTDPESNLLFFGICLIIDRKQFSSFDSLIDLTNKEDCDSPLERLLGDFIGSDLSTAYYILAQGKPEQLSRLVNSQQAGELVKMAALSALFSQLHTGQIDRDTLNHSIPSFIDSLVKNNHSIALFELINLLISNQFNQYHSQLVAYVQSKVIDEGPAENQCIIDWDNQSIGYSEWESGLISGNYDVIDSLSHWAGFNAESEMNDEDLMAVFDDLMNTPSELDERYFEALDYQQPFIADIQVGRNDPCPCGSGKKYKKCCLN
>NC_014012.1|WP_013049313.1|25903_27265_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MTEDTIVAQATAPGRGGVGIIRISGDQASEVAMAMLGHIPKTRYADYCDFKTADGVVIDQGIALYFKGPNSFTGEDVLELQGHGGQIVLDMLIKRVLETKDIRIARPGEFSEQAFMNDKLDLTQAEAIADLIDATSEQAAKSALNSLQGEFSTEVHALVEKVTNLRLYVEAAIDFPDEEVDFLSDGKIAGSLNKIITRLDSVKASAKQGSIIREGMKVVIAGRPNAGKSSLLNALAGKESAIVTEVAGTTRDVLREHIHIDGMPLHIIDTAGLRDTSDTVEKIGIERAWAEIETADQVLFMVDGTTTDAVDPHEIWPDFIDRLPSKLGITVVRNKADLTGESLELTQDHGHPVYRISAKTGLGIDSVKQHLKSLMGYQSNLEGGFIARRRHLEALDLASSHLMLGKEQLEVYLAGELLAEELRMSQMALSEITGKFTSDDLLGKIFSSFCIGK
>NC_014012.1|WP_013049314.1|27387_29022_-|membrane-protein-insertase-YidC
MESQRNIFLIGLLFVSFLLWQQWQTDQAPQPVTTELTSVSTASNTTDAHSSDVPDADSALPAATVASKELITIHTDQLVIKINPVGGDIVYSALVEHKLEQESDEPFVLLEQTKDINYIAQSGLIGRNGIDSSVKGRAHFDSASQDYTMAADQETLEVPLTYVAENGAKYTKMFIFHRGQFKIDVDYLVDNTTDKPLQVQMYGQIKHSIKKSSSSMIMPTYLGAAFSTSDIRYEKYKFDDMADKDLDKKTLGGWAAMLQHYFVSAWIPPENDQNTIFSSISAGGQANIGFRGAIYDIAPGATQTISSQFYVGPKDQEALSEISDSLNLVVDYGFLWWLAVPINKLLMFFQSIVSNWGLAIILITLTVRGMLFPLTKAQYTSMAKMRNLQPKLAEMKERFGDDRQKMGQAMMELYKKEKVNPMGGCLPILLQMPIFISLYWVLMESVELRHAPFMLWITDLSVQDPYYVMPILMGISMFVMQKMQPMAPTMDPMQQKMMQWMPVVFTVFFLWFPAGLVLYWLVGNLVAITQQKIIYAGLAKKGLK
>NC_014012.1|WP_013049315.1|29025_29283_-|membrane-protein-insertion-efficiency-factor-YidD
MAKTHSPLQWLATTIIRGYQILISPLLGTNKCRFHPTCSYYAIEAIHLHGFVKGSWLTAKRVLKCHPLHPGGIDPVPSKKHRCNK
>NC_014012.1|WP_013049316.1|29249_29606_-|ribonuclease-P-protein-component
MTSYTFTRELRLLTPAQFKSVFAKPIKASSAEITLLAIPNSEQHPRIGLTVAKRFVKKAHQRNRIKRIIRDNFRLHQHELPPVDIVVLVRNGVVEMENAELHKLVEKLWRKLTRRYNG
>NC_014012.1|WP_006083827.1|29620_29758_-|50S-ribosomal-protein-L34
MSKRTFQPSNLKRKRSHGFRARMATVGGRKVLARRRAKGRARLSA
>NC_014012.1|WP_013049317.1|30204_31593_+|chromosomal-replication-initiator-protein-DnaA
MAVTLWQQCLGRLQDELSAQQFSMWIRPLQAEMDGNTLVLYAPNRFVLDWVRDKYINIINQFFTEQMGSDAPKLRFDIGSKPAAPRPIQATPAMAPPRVQMNTRPAKTTFNMNMPEPAIMANHRSNINPAYQFENFVEGKSNQLGKAAALQVAENPGGAYNPLFLYGGTGLGKTHLLHAVGNAIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDRSQEEFFHTFNALLEGNHQVILTSDKYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAILMRKAQESGVNLPDEVAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVARPRQVAMALSKELTNQSLPEIGDAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS
>NC_014012.1|WP_013049318.1|31612_32713_+|DNA-polymerase-III-subunit-beta
MKFSIDRDALLKPLQLVNGAVERRHNLPILANLLVEVSGHSLKMTGTDLEVELVGQVQLEGDVVEGRITVPAKKFLDIVKSLPDQVELKIEQQENRLLLRSGRSRFTLATLPAEEYPNVEAFQSDIEFTIKQGTLKSLIDATQFSMANQDVRYYLNGLLLETDGNVLRAIATDGHRLALSHRQIEATLPEKQVIVPRKGVVELQRLFEGEDLDVTIAIGDNAIRATTSSAVLTSKLVDGRFPDYRRVLPKGGDKVVIASRNQLKQALLRASILSNEKFRGVRVQLENNLLKITANNPEQEEAEEIIDVEYDNTPLEIGFNVSYLLDVLNNLPSDDVRITLIDGNSSALIENHIEEDSMYVVMPMRL
>NC_014012.1|WP_013049319.1|33110_34208_+|DNA-replication/repair-protein-RecF
MSLTRLHIETFRNIASAQLLPAEGINLIYGLNGSGKTSILEAIYFLGMGRSFRSHLSQRVIQHSDDKLTLFAKLNVQNKESKIGLRRFRSGETEVKIDGDKIKRLSTLAESLPIQVITPESFALLFDGPKSRRQFIDWGAFHCDKSFHSAWVNVKRILKQRNQLLKNEAGYSQIQYWDTELVRYSEVVTDIRTQYVNSLNEQLKGIIGEFLPQVDVKVSFTRGWDSKTDYAQLLETQYPRDVSSGNTASGPHKADLRLRVGTLPVQDALSRGQLKLLVCALRIAQGKLLKQQIDKNSIYLVDDLPSELDAKHRQLLLQQLTDTGAQVFVTAIEPAAILDSLNTPPSKVFHVEQGRVTVIEQPTRE
>NC_014012.1|WP_013049320.1|34209_36630_+|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B
MSENSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGSGLHHMVFEVVDNSIDEALAGHCSEVIITIHADNSVSVKDDGRGIPVDIHPEEGISAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLQLTIRRNGKLYEQFYTMGVPDAPIKEIGDATSTGTELRFWPSHETFTTNIKFHFDILVKRVRELSFLNSGVGIRLIDERDNRDEFFQYQGGISAFVDYLNVNKTAVNKDVFHFIQERDDGITVEVAMQWNDGFQENIFCFTNNIPQRDGGTHLAGFRGALTRNLNAYMEREGYNKKGKTNATGDDAREGLTAVISVKVPDPKFSSQTKDKLVSSEVKSAVEQTMGEKLGDYLMEHPNEARLIVGKIIDASRAREAARKAREMTRRKGALDLGGLPGKLADCQEKDPALSEIYIVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYDPDKTRYHNIVIMTDADVDGSHIRTLLLTFFFRQMPELIERGYIYIAQPPLYKVKKGRQEQYLKDELALTEFLTNLALDGGELHSSADAPAISGAPLEKLVYQYREVETIFDRLNMRYPTLLTERMLYHPALDAEMLADEAKVKQWCDEFVADLTEKESGGVMYSADPVMDPERKVYLPNVHIRKHGIDTSYLFTYDFLNSSDYERMAKLAAALEGLIVEGGYIKRGERMKEISTFVEALNWLMNDSRRGLYIQRYKGLGEMNPEQLWETTMDPETRRMLVVTIEDAIGADQLFTCLMGDQVEPRRQFIEENALNVANLDV
>NC_014012.1|WP_041419529.1|37105_37528_+|hypothetical-protein
MKNFAKLGVITLVSLLSFSSVAGSSSPGKDWVKVADTELKSGINNINIDNNFREKRFDMIKLKPMKENMRIRDLYVIMKGDDGATSHQMFGLLRKGSFSQGAMVKESNKSIASFTINFDKNIANSINFRKSSIEIWAHKA

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Crispr_ID: NC_014012_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_2

816770-816885

Orphan

Consensus_repeat	Method
ATATTTAACAAGAATTTAGCGGCTCGCATTAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014012_2

>merge|NC_014012|2|816770-816885|CRISPRCasFinder
ATATTTAACAAGAATTTAGCGGCTCGCATTAGCGCATCAATAATCAGAAAATCAGAAGCCCATCAAGATACTCTAGGCCAGACATATTTAATAAGAATTTAGCGGCTCGCATTAGC

>NC_014012|2|2|816770-816885|CRISPRCasFinder
ATATTTAACAAGAATTTAGCGGCTCGCATTAGC	GCATCAATAATCAGAAAATCAGAAGCCCATCAAGATACTCTAGGCCAGAC
ATATTTAATAAGAATTTAGCGGCTCGCATTAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_013049973.1\|824843_826820_+\|TRAP-transporter-fused-permease-subunit	unknown	unknown	gnl\|CDD\|273983
NC_014012.1\|WP_013049962.1\|814164_815730_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225962
NC_014012.1\|WP_041420190.1\|819478_821110_+\|nitric-oxide-reductase-transcriptional-regulator-NorR	unknown	unknown	gnl\|CDD\|235331
NC_014012.1\|WP_013049960.1\|812507_812867_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|366361
NC_014012.1\|WP_041419634.1\|823753_824680_+\|TAXI-family-TRAP-transporter-solute-binding-subunit	unknown	unknown	gnl\|CDD\|270287
NC_014012.1\|WP_172634428.1\|826966_827485_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|168472
NC_014012.1\|WP_013049965.1\|817468_818716_-\|NO-inducible-flavohemoprotein	unknown	unknown	gnl\|CDD\|237337
NC_014012.1\|WP_013049966.1\|818890_819190_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_041419629.1\|803400_804702_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274576
NC_014012.1\|WP_041419632.1\|813519_814059_-\|DUF924-domain-containing-protein	unknown	unknown	gnl\|CDD\|377592
NC_014012.1\|WP_013049971.1\|822493_823285_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277347
NC_014012.1\|WP_013049964.1\|816992_817283_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|370745
NC_014012.1\|WP_041419630.1\|811298_811931_+\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NC_014012.1\|WP_013049976.1\|827923_829078_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|181642
NC_014012.1\|WP_157608646.1\|815731_816664_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225937
NC_014012.1\|WP_157608782.1\|807852_809241_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|227333
NC_014012.1\|WP_013049970.1\|821960_822335_+\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|377953
NC_014012.1\|WP_013049954.1\|806221_807778_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_014012.1\|WP_013049953.1\|804734_805946_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|274576
NC_014012.1\|WP_013049957.1\|810420_811227_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_013049973.1\|824843_826820_+\|TRAP-transporter-fused-permease-subunit	gnl\|CDD\|273983	TIGR02123, conserved_inner_membrane_protein, TRAP transporter, 4TM/12TM fusion protein. In some species, the 12-transmembrane spanning and 4-transmembrane spanning components of tripartite ATP-independent periplasmic (TRAP)-type transporters are fused. This model describes such transporters, found in the Archaea and in Bacteria. [Transport and binding proteins, Unknown substrate].	3.03905e-164
NC_014012.1\|WP_013049962.1\|814164_815730_-\|PH-domain-containing-protein	gnl\|CDD\|225962	COG3428, COG3428, Predicted membrane protein [Function unknown].	3.32241e-41
NC_014012.1\|WP_041420190.1\|819478_821110_+\|nitric-oxide-reductase-transcriptional-regulator-NorR	gnl\|CDD\|235331	PRK05022, PRK05022, nitric oxide reductase transcriptional regulator NorR.	0
NC_014012.1\|WP_013049960.1\|812507_812867_+\|VOC-family-protein	gnl\|CDD\|366361	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	1.14204e-10
NC_014012.1\|WP_041419634.1\|823753_824680_+\|TAXI-family-TRAP-transporter-solute-binding-subunit	gnl\|CDD\|270287	cd13569, PBP2_TAXI_TRAP_like_1, Substrate binding domain of putative TAXI proteins of the tripartite ATP-independent periplasmic transporters; the type 2 periplasmic binding protein fold. This subgroup includes uncharacterized periplasmic binding proteins that are related to Thermus thermophilus GluBP (TtGluBP) of TAXI-TRAP family. TRAP transporters are comprised of an SBP (substrate-binding protein) and two unequally sized integral membrane components. Although TtGluBP is predicted to be an L-glutamate and/or an L-glutamine-binding protein, the substrate spectrum of TAXI proteins remains to be defined. A sequence-homology search also shows that TtGluBP shares low sequence homology with putative immunogenic proteins of uncharacterized function.	3.45488e-108
NC_014012.1\|WP_172634428.1\|826966_827485_+\|AAA-family-ATPase	gnl\|CDD\|168472	PRK06217, PRK06217, hypothetical protein; Validated.	2.45461e-14
NC_014012.1\|WP_013049965.1\|817468_818716_-\|NO-inducible-flavohemoprotein	gnl\|CDD\|237337	PRK13289, PRK13289, NO-inducible flavohemoprotein.	0
NC_014012.1\|WP_013049971.1\|822493_823285_-\|metallophosphoesterase	gnl\|CDD\|277347	cd07402, MPP_GpdQ, Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain. GpdQ (glycerophosphodiesterase Q, also known as Rv0805 in Mycobacterium tuberculosis) is a binuclear metallophosphoesterase from Enterobacter aerogenes that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. The GpdQ homolog, Rv0805, has 2',3'-cyclic nucleotide phosphodiesterase activity. GpdQ and Rv0805 belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	4.65308e-19
NC_014012.1\|WP_041419629.1\|803400_804702_+\|ABC-transporter-permease	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	1.59985e-34
NC_014012.1\|WP_041419632.1\|813519_814059_-\|DUF924-domain-containing-protein	gnl\|CDD\|377592	pfam06041, DUF924, Bacterial protein of unknown function (DUF924). This family consists of several hypothetical bacterial proteins of unknown function. Structurally, this family resembles TPR-like repeats.	4.50731e-92
NC_014012.1\|WP_013049964.1\|816992_817283_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|370745	pfam09904, HTH_43, Winged helix-turn helix. This family, found in various hypothetical prokaryotic proteins, is a probable winged helix DNA-binding domain.	1.26414e-54
NC_014012.1\|WP_041419630.1\|811298_811931_+\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	2.76165e-20
NC_014012.1\|WP_013049976.1\|827923_829078_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|181642	PRK09082, PRK09082, methionine aminotransferase; Validated.	0
NC_014012.1\|WP_157608646.1\|815731_816664_-\|PH-domain-containing-protein	gnl\|CDD\|225937	COG3402, COG3402, Uncharacterized conserved protein [Function unknown].	2.63567e-23
NC_014012.1\|WP_157608782.1\|807852_809241_+\|PAS-domain-containing-protein	gnl\|CDD\|227333	COG5000, NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms].	3.92152e-34
NC_014012.1\|WP_013049970.1\|821960_822335_+\|PH-domain-containing-protein	gnl\|CDD\|377953	pfam08000, bPH_1, Bacterial PH domain. This family contains many bacterial hypothetical proteins. The structures of Structure 3hsa and Structure 3dcx show similarities to the PH or pleckstrin homology domain. First evidence of PH-like domains in bacteria suggests role in cell envelope stress response.	4.526e-64
NC_014012.1\|WP_013049954.1\|806221_807778_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.25426e-136
NC_014012.1\|WP_013049953.1\|804734_805946_+\|FtsX-like-permease-family-protein	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	1.03685e-35
NC_014012.1\|WP_013049957.1\|810420_811227_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.99352e-22

>NC_014012.1|WP_157608646.1|815731_816664_-|PH-domain-containing-protein
MDNPKDLVKATNKAAENASGNASGNAAANLQAHERVAEKTSDTEHKLPRQNQAQSDWLGFDQVPLTPVDPRHYTQVLCESIIGALVLFSLVSVFIILVAQLPIKIALAALSVLGLILGIITWLSYAHAKSIAFAVCDHELLMQKGIIWFKRISLPYSRLQHISLSQGPLERKFGLHTLKCFSAGSGSAEIELPGLESRTAEKLRQHLLAKAGIANQGAKPSIEPEPSINPDLSINPNSSINPNSSINPNSSINPNSSINPNSSINPEPSINLDSSINLEPSINRSTDTSQDTSLEGLESKTASLTTESER
>NC_014012.1|WP_013049962.1|814164_815730_-|PH-domain-containing-protein
MHKRFSLWSGLSPWSIISYTLNTIRLVISNGYAMVPVVYTGWQQGFNSPWVIVAAVGVALAVLVYAIVQWAMFRYRLYEDKLGVRQGLIFKKTHEIPLSKIQNVRLEQPFYFRPMGLYSLVVETAGSKEDEAVLAAVNYRQAIQLKHKLVNPLLPTPREGVEANREDGTQAGVTSEGAGKHATQGNNSPNTKSESLVRKGFKPLLLFGLYQNNLFWFVIISGPILGQLDWSQLADTHLAQSAWLWYEQAVGTNLLYQVLFASLLFISFCLLLSLVSMAASVLKYYPYHLSRNSSTLHRSGGIIAKQSDALALQRIQVIRFSQPIIARLLKLWTVYFKQVKGTEVEQKSQSHMLVPSMTRRTVSALLKNMQGIEARTTELPKHYHPIHFGWYWRRALAPIMVPAASTIAMGFTPLTELLWLIGVGLSLGLYLRYRQWGYFLDGSDCWIHTGTLGHSWHLIALNKIQHVAIIQTKGQRKKGLASLELGLASGTLTIPYLPLSDAREIAERALAMTGRSHQNWI
>NC_014012.1|WP_041419632.1|813519_814059_-|DUF924-domain-containing-protein
MTPETIINFWFDEIEPKAWWVKDTEFDALIKHRFGLLVEQAKVGELYHWRATPQGRLAEIILLDQFCRNIHRDTPQAFTSDPLALALAQEAVARGADTELKAKQVPFLFMPYMHSESRKVHEIAMVLFNREAAAGNLEFERRHKAIIDQFGRYPHRNKILGRESTPEEVEFLSQPGSSF
>NC_014012.1|WP_013049960.1|812507_812867_+|VOC-family-protein
MDSPSTLLVVRDLSISREFYVNILGLNILEEYEDSLKFQIGSHSVFMFQGTMEATDYEHGFNANSALVFTVSDLDEKIKELKENGVVFVHESPNENRWGRYAAFKDPSGIIHELMEFCT
>NC_014012.1|WP_041419630.1|811298_811931_+|LysE-family-translocator
MSLFIIWLGVMFPLVFSPGPANIVFAASGARVGIKRSIPLVAGIDSIFIIKSIIIGYGLGEVVKSHPEIMNSLQLVGAIYLVYVAVKFMRPNSSKSENISTELGFFDGLLIQLLNSKGWLMVFLMFSLFTEPSQDIFGDKGVAVLIIWLAFLNISMHFVWVSIGEFLSRVSSSPLYEKWLSFFYACCLIAVSIWLIIENPMVITYLGIST
>NC_014012.1|WP_013049957.1|810420_811227_+|AraC-family-transcriptional-regulator
MEKSKIWINKTFKGVELLSASYTKFKFTKHWHDELAIGVIEDGAEGLFYRGDNLIIPKRHIVAINPSEVHTGFSGAPNGWRYRMFYFNLKELDSEFSNRDMPIDPIINSPIIYDEYLFNILFQLHVSLEKPSFELTKESLFSLAIEKLFRQYGSAKRERFNSICTTSSYLARDFIQDNFEFNPSLSELEKISNCSKFQLIRSFKIIFGITPHQYLLLIKVKNAKKLLSKGLSCVDTSLACGFCDQSHFIRNFKKAFGISPSNYLNDKG
>NC_014012.1|WP_157608782.1|807852_809241_+|PAS-domain-containing-protein
MDDCAMTLRSKLILASVLACFLGLVSAGLLFNWLGQDYLVLIALLSLGLVWAVSHYMTRNLADCLAALEVGLLNFKDNDFSISIPVKGDEQLRTLARLFNESAHTLRRERQFIYQRELLLDKVIQSSPNVMILLDDEQRVIYANDAARHLFNQGVPIEGLHLHELIEACSPELITALNNPKDGLFTLGAKESLGTDIQGETSDETMNEDETWHLSRGRFKLNGQLHHLLLLKQMTHELNRQEVAVWKKVIRIISHELNNSVAPIASMVNSGRMITKDLNDPKLKMIFDTIDDRTQHLSQFIFNYARFAKLPLPNKSMVNWLKMTEHLSHHYKFTLDGSLPEGDGYFDLIQMEQVLLNLLKNAHESGSKVDEITMSITQANPSHGVDSASGNKGILISICDAGSGMSSEVLKQALLPFYSTKQSGTGLGLPLCREILEAHDGRISLHNREETGLCVKLWLPQS
>NC_014012.1|WP_013049954.1|806221_807778_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MDTILIVDDNQAVCDALALMLELHGYKTHSCLSPEVALELVKIHDIALVIQDMNFTQDTTSGEEGKSLFYELRSLQPLLPIVLITAWTQLDIAVELVKEGAVDYMGKPWDDAKLLNSVSNLISLHTLSRENTQYQRAESQRMVAIKDADLCGIVFASGSMQRSVDLALQIARSDVSVLITGPNGAGKDKLADIIHANSPLKNKPFIKVNIGALPMDLLEAELFGAEAGAFTGANKTRIGRFEAADGGTLFLDEIGNLSLSGQIKLLRVLQTGEFERLGSHQTRKVKVRVLSATNAELALDIREGRFREDLFYRLNVIELELSPLNQRQDDILPLVSHFIGPNFSLNKQTQRALEAHAWPGNVRELENACKRAVILAPSKLLTPLDFGLSAEPVQDNPVSGPELKQELTLELKPVLKSELKQELASDSKPELKPVLKRELKPESAIDQKADTPRVPDSASDNAHSSASSSTRSSISVIDKTSIQAELHRHHGVIARVAKSLGLSRQALYRRMEKFGINK
>NC_014012.1|WP_013049953.1|804734_805946_+|FtsX-like-permease-family-protein
MLHIKPIINTLMRSKSGPILLLIQIILSVAIVANASFIIGERLALMDRESGTEEEQVFNFLLYAFDSGIDIESQIPRDIRAIRELPGVIDATTTSMVPLSGGGWSSGYTIGDSEETAKDTENTAIYYGDDHMVNTLGVDLIEGRNFYETEVLTGSPDLATHGIVSKAFAKKTWGDESAIGQIMYAGGWGDKPIQIIGVVDKLQGAWVNSSYLDNSVILNVRLVNMFSKVLVRVEVGTLAQLKQVIPAMLHKDEPNRVIEDFTLISEHRKRVYRNHELMATVLSMMVILLLLITSLGLAGMVMFNIERRTKQIGTRRALGAKRRDIISLFLVENYIICIVGGIIGGLVAVQLGQQLMTFYSLPKLELIYPIVTVAGMMVLTTIAVILPARKAASISPATATRSV
>NC_014012.1|WP_041419629.1|803400_804702_+|ABC-transporter-permease
MFFYYLDLAWRSIKKTPLLSLLMVFAISVGISTTITTLNVYQLMSVNPAGERSDKLLAVQLWSQGKDAWKEFNAQVTYQDAFNLRKSELPVRQTPMFVTGLAVQTEDADFSPLLETVRVTDSDFFGMFSVPFLYGGAWDKSVDTQAAYQVVINEDLNKQLFAGENSVGKTLFLDSKPYQVVGVIKTWSPSPQYYDLTTGAFKDSAQLFIPFSLTPMEEFQSWGNNQSWKRESMDTYNGRLNSEMHWIQFWVEVTDDKQRDEYAQWLTAYVEQQQLLGRFESPEAGAQLSNVAQWLDLNEVVPEDNKILVGLSGLFLLVCLVNMLGLLLAKFLKRAPEVGVRRAIGASRNQIFAQHMVEVGLIGFCGGVLGLIWAWGSLSMLSARFNLEESLTHLDPSMWIIAPAIAICAALVAGIYPAWRICSTNPSVHLKSQ
>NC_014012.1|WP_013049964.1|816992_817283_+|helix-turn-helix-domain-containing-protein
MDIEVSKQKKAFLRKLYLAHTIDSDQHNLLSLNKLTGMPRRTLQDSIAALSDIGVECQFIQDGERNNSGHYKISSWGPISSAWVDTHLDEITKLLA
>NC_014012.1|WP_013049965.1|817468_818716_-|NO-inducible-flavohemoprotein
MLSAKHIELVKSTIPLLESAGTGITEYFYQRMFKHNPELKHIFNMTNQRTGGQPAALFGAIAAYAKNIDNLGALSGAVERIAHKHTSLNIQPEHYPIVGHHLLATLRELAPEAFTAEVEEAWAAAYGLLAGIFINREDELYQKNANQVGGWLGARQFKLVEKQQESALVTSFVLAPVDGEPVVDYQAGQYLGIKVEPANHEYREMRQYSLSDKPNGKTYRISVKREDAKNPKDEPGTVSNYLHDQLNIGDVMDIFPPAGDFHYVERNEPVVLISAGVGVTPMQSMLEMLASKAFDKPVFYLHACENLAQHSFNERVQALTNTLTLTQHTWYRELDGNEQESLNCQSLNQSNSGSVNSHMGFMNLVPIKAELPLARGDFYLCGPVAFMSFVKQQLIEIGVEDSRIHYEVFGPHADL
>NC_014012.1|WP_013049966.1|818890_819190_-|hypothetical-protein
MHATQANDFSFTHDTEFSKDSLKPSPRGFKLALHTGNAVMLIAVLGILLSIFVAYAHAEQFSLWAQVASHITLILCATAIKIGYVIRCIGLHGLGAIQL
>NC_014012.1|WP_041420190.1|819478_821110_+|nitric-oxide-reductase-transcriptional-regulator-NorR
MIDISSTALIELALDLANSLTTKDRFDRLLSTVRRTVNCDAVVLLHVQGERLKPLAQQGLSKDSLGRRFDIQAHPRFEIICGSQTPVRFAADCMLPDPYDGMLLGHEGDLPVHACMGLPLLADGLLIGVLTLDSMTPQVFDELPKRTLDVISSMSAATLKTAILLQELESHSLHSQELVAELTNEALVKDGGELIGDSPVMLKLKREIDMVAVSGFSILIEGETGVGKELVARTLHRQSARSDGPLVYVNCAALPENLIESELFGHVKGAFTGADRNRTGKFSLADGGTIFLDEIGELPLGVQSKLLRVLQSQEIQPVGKDATEQVNVRILAATNRKLKLEVSEARFRADLYHRLSVYPISVPPLREREGDVTLLAGYFIEQIRRKLGIRQLAIDASAISILNRYDWPGNVRELEHVIGRAALRAKGRGDQAIVRIDTRHIEQLVDSVERSEGLLLSSSSNGLNTDVLTTVLTAGLVVDKGTSVSLKLETEAFQCKLITRVLSQESGNWSAAAKRLQTDRANLSRLAKRLGISVTKAVTLSTD
>NC_014012.1|WP_013049970.1|821960_822335_+|PH-domain-containing-protein
MGLLDSLLGNASEVNLEELADELGPILADNEELHLAYKLIRDMFVFTNKRLILIDKQGLTGKKVSYHSIPYKAITHFEVETAGRFDMDSELKLWISGQDKPLVKELKKGTDVVGIQKTIANFML
>NC_014012.1|WP_013049971.1|822493_823285_-|metallophosphoesterase
MKIYQVSDCHLYLDEAQPRDNLIRALALIELQGDGDILLLTGDLVCDPNIEIYTQFKAIVQAHSSIDRIFAIAGNHDDLTMMKSVFKGSRVQVKSHVHLGDDLSLCFVDSSPKPLAHMSLGAGRVARKALSSLKQFTRKYRSIVVIHHPVVNLGAKWFTQIGIENNLDVVAAIHPQTLAILSGHAHAFFKDNLTSPQGKIIPLIVSPATSYGFEHSNPDYEKNTNIGIMAYDIRLDIGSQSPTKSCKSKPNYLIHESVINLSH
>NC_014012.1|WP_041419634.1|823753_824680_+|TAXI-family-TRAP-transporter-solute-binding-subunit
MSYRAITLALLLILPAAVHAENYSIGTGGQSGIYYPFGGALAKIWSDKIPGVNVKAEVTAASVENTIKVVRGDMIAGIAMGNVVLDAYKGEGKFRSKMPVKTLFALYPNLVHTLALEKSGIKSLGDLKGKRISLGAPASGTAVTAAALLASVGIDVKKDIDAVYLNYSETTNALANGQIDAGFIVGGQGVGAVTQISLTHKVNIIPISDAQSTAFIEKNPAYSKYTIPADVYNKVGEVSTLSVWNVVVVSAKMSDEMAYNLTKSAFENMGEVRKVVKVAEATTPENAHRLAGVPLHIGAQKYLDSLAQ
>NC_014012.1|WP_013049973.1|824843_826820_+|TRAP-transporter-fused-permease-subunit
MTQTNNITLGHDEPVLEDIPSIDVCSSASLIKADPLPNEGVFKLLGYLILTLAVSLSAFQIWQGITSTISATYFRPVHLSWVLVLIFLNYPLISDRYNKGYLPGRVLDLALCGLALFAAYRMSIFDYNDIDHLLYGLKMPDLLAGSALLLLLMEGCRRTVGWVMVLISALFLSYSAFGDILPSAIATKGYSLQELIQFQIYSANGVFGSALGIAATTVFIFVLFGAFLEVTGAGKFFIDLSFSIAGKYRGGPAKAAVLASAGLGSISGSAIANTVTTGSVTIPMMKQLGYKPEQAAGIEAAASTGGQIMPPIMGAGAFVMAQFTGVPYSEIMLASIAPAILYFFCTLLYVHLMACKLNLKAVSRTEAVISVMKHGAHYLIPLGLITALLMMAYSPLLVGVAGCGAILVTAALRKHSRIGLSQFIQGMKNGALMALPISVACGAAGIIVGVVGQTGIGLQFTQFVMEFSGGYMLVALGLISIVALILGMGLPVTAAYIVLAVMAVPMLGDFGLPLLTAHLIIFWLSQTSNVTPPIALAAFAAAGVAKANPMKSSVEAFKLAGGLFIIPIMMAYTDLINPEASVLEFGFAIAQTAAIILALAISIEGYLLRPLSKMERIIAFMMAPLILFNFFGVGFVGILVICGLILMQWKSRELAEGT
>NC_014012.1|WP_172634428.1|826966_827485_+|AAA-family-ATPase
MARRVLIFGNSGSGKSTLAKRLASSDGLAHLDLDSLAWQPYEPPKPPERMPLNESAYKLKTFTQGNQNWVVEGCYTDLLQLLVGNVTELIFMNLPVDLCIENAKQRPWEPHKYPSKQAQDANLSMLIEWIAQYDLRDDTFSRRAHEDFYSAFQGKKTRYLSNLSSTRNSRDI
>NC_014012.1|WP_013049976.1|827923_829078_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MSTLDHSSKLPNLGTSIFTYMTGLANQYQAINLSQGFPEFDAPKLLKQGLAKYCDLGFNQYAPSPGLAPLQAQIACLIGRQYGIDVNPNDTVTVTSGATEALFVTIQAITHPGDEIIIFDPAYDSYKPAIELAGGRAVHIPMLAPDYAIDWQLVAAAITDKTRGIIINTPHNPSAKTLKQADFDELKALVIEHDLLIISDEVYEHIIFGNTPHISILTDAELFSRAFVISSFGKTFHCTGWKMGYCVAPKMLTQEFRKIHQYVTFSSFTPAQLALTDMLAQEPEHITALAAFYQHKRDVLVNALQNSRFTILPSEGTYFLLLDYSEISGLDDMSFCEYLVKEIGVAAIPLSVFYQTAPGDKVIRLCFAKEDKTLLQAAEKLSAL

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Crispr_ID: NC_014012_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_3

1024928-1025001

Orphan

Consensus_repeat	Method
GGCATAAGTGTTCCAGACACAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014012_3

>merge|NC_014012|3|1024928-1025001|CRISPRCasFinder
GGCATAAGTGTTCCAGACACAAAGTCCACAGTTTGCCATCCTTGGCCTGTGGGCATAAGTGTTCCAGACACAAA

>NC_014012|3|3|1024928-1025001|CRISPRCasFinder
GGCATAAGTGTTCCAGACACAAA	GTCCACAGTTTGCCATCCTTGGCCTGTG
GGCATAAGTGTTCCAGACACAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_013050154.1\|1012911_1013424_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378964
NC_014012.1\|WP_013050148.1\|1005869_1006052_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_157608657.1\|1007349_1010019_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013050164.1\|1030552_1031566_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl\|CDD\|236585
NC_014012.1\|WP_013050155.1\|1013487_1014672_-\|PD40-domain-containing-protein	unknown	unknown	gnl\|CDD\|274305
NC_014012.1\|WP_013050150.1\|1006659_1006845_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013050166.1\|1032563_1032917_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|214902
NC_014012.1\|WP_013050167.1\|1032917_1033448_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|376515
NC_014012.1\|WP_013050168.1\|1033516_1034317_+\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|234712
NC_014012.1\|WP_157608789.1\|1019198_1021301_-\|cellulase-family-glycosylhydrolase	unknown	unknown	gnl\|CDD\|365907
NC_014012.1\|WP_013050162.1\|1029568_1030012_-\|GatB/YqeY-domain-containing-protein	unknown	unknown	gnl\|CDD\|370480
NC_014012.1\|WP_013050158.1\|1021477_1023688_-\|glycoside-hydrolase-family-6-protein	unknown	unknown	gnl\|CDD\|227616
NC_014012.1\|WP_083779927.1\|1010281_1012735_-\|glycoside-hydrolase-family-6-protein	unknown	unknown	gnl\|CDD\|227616
NC_014012.1\|WP_041419665.1\|1025764_1027618_-\|RNA-polymerase-sigma-factor-RpoD	unknown	unknown	gnl\|CDD\|235549
NC_014012.1\|WP_013050169.1\|1034380_1035337_+\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|236841
NC_014012.1\|WP_013050161.1\|1027737_1029465_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NC_014012.1\|WP_013050156.1\|1014877_1019014_-\|cellulose-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366161
NC_014012.1\|WP_013050163.1\|1030018_1030234_-\|30S-ribosomal-protein-S21	unknown	unknown	gnl\|CDD\|234707
NC_014012.1\|WP_013050165.1\|1031670_1032279_-\|glycerol-3-phosphate-1-O-acyltransferase-PlsY	unknown	unknown	gnl\|CDD\|234691
NC_014012.1\|WP_013050149.1\|1006106_1006454_-\|DUF3634-family-protein	unknown	unknown	gnl\|CDD\|315081

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_013050154.1\|1012911_1013424_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|378964	pfam12833, HTH_18, Helix-turn-helix domain.	2.759e-20
NC_014012.1\|WP_013050164.1\|1030552_1031566_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl\|CDD\|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	0
NC_014012.1\|WP_013050155.1\|1013487_1014672_-\|PD40-domain-containing-protein	gnl\|CDD\|274305	TIGR02800, Protein_TolB, tol-pal system beta propeller repeat protein TolB. Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	3.75977e-15
NC_014012.1\|WP_013050162.1\|1029568_1030012_-\|GatB/YqeY-domain-containing-protein	gnl\|CDD\|370480	pfam09424, YqeY, Yqey-like protein. The function of this domain found in the YqeY protein is uncertain.	1.40497e-54
NC_014012.1\|WP_013050166.1\|1032563_1032917_+\|dihydroneopterin-aldolase	gnl\|CDD\|214902	smart00905, FolB, Dihydroneopterin aldolase. Dihydroneopterin aldolase catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. In the opportunistic pathogen Pneumocystis carinii, dihydroneopterin aldolase function is expressed as the N-terminal portion of the multifunctional folic acid synthesis protein (Fas). This region encompasses two domains, FasA and FasB, which are 27% amino acid identical. FasA and FasB also share significant amino acid sequence similarity with bacterial dihydroneopterin aldolases. This region consists of two tandem sequences each homologous to folB and which form tetramers.	3.9677e-42
NC_014012.1\|WP_013050167.1\|1032917_1033448_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|376515	pfam01288, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK).	1.36753e-42
NC_014012.1\|WP_013050168.1\|1033516_1034317_+\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|234712	PRK00281, PRK00281, undecaprenyl-diphosphate phosphatase.	3.23254e-110
NC_014012.1\|WP_157608789.1\|1019198_1021301_-\|cellulase-family-glycosylhydrolase	gnl\|CDD\|365907	pfam00150, Cellulase, Cellulase (glycosyl hydrolase family 5).	2.42958e-35
NC_014012.1\|WP_013050158.1\|1021477_1023688_-\|glycoside-hydrolase-family-6-protein	gnl\|CDD\|227616	COG5297, CelA, Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism].	2.0423e-127
NC_014012.1\|WP_083779927.1\|1010281_1012735_-\|glycoside-hydrolase-family-6-protein	gnl\|CDD\|227616	COG5297, CelA, Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism].	2.63017e-101
NC_014012.1\|WP_041419665.1\|1025764_1027618_-\|RNA-polymerase-sigma-factor-RpoD	gnl\|CDD\|235549	PRK05658, PRK05658, RNA polymerase sigma factor RpoD; Validated.	0
NC_014012.1\|WP_013050169.1\|1034380_1035337_+\|SAM-dependent-methyltransferase	gnl\|CDD\|236841	PRK11088, rrmA, 23S rRNA methyltransferase A; Provisional.	1.18919e-50
NC_014012.1\|WP_013050161.1\|1027737_1029465_-\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NC_014012.1\|WP_013050156.1\|1014877_1019014_-\|cellulose-binding-domain-containing-protein	gnl\|CDD\|366161	pfam00553, CBM_2, Cellulose binding domain. Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.	2.54557e-23
NC_014012.1\|WP_013050149.1\|1006106_1006454_-\|DUF3634-family-protein	gnl\|CDD\|315081	pfam12321, DUF3634, Protein of unknown function (DUF3634). This family of proteins is found in bacteria. Proteins in this family are typically between 103 and 114 amino acids in length.	2.91224e-46
NC_014012.1\|WP_013050165.1\|1031670_1032279_-\|glycerol-3-phosphate-1-O-acyltransferase-PlsY	gnl\|CDD\|234691	PRK00220, PRK00220, glycerol-3-phosphate 1-O-acyltransferase PlsY.	3.34464e-97
NC_014012.1\|WP_013050163.1\|1030018_1030234_-\|30S-ribosomal-protein-S21	gnl\|CDD\|234707	PRK00270, rpsU, 30S ribosomal protein S21; Reviewed.	1.71483e-17

>NC_014012.1|WP_013050158.1|1021477_1023688_-|glycoside-hydrolase-family-6-protein
MRSGLIKGVTLTSMLLATLQANAAVKCDYSIENEWETGFVGAIQLKNTGETLIDGWQVSWQYLDGSTVSSAWNSTFSGNSPYLASNLVWNNLIQPGETITFGIQGEKGIPNKAASTPKISGEICTREANNSAPMTSFTIIESGLDISFDASATRDADGDELTYSWDFGDETLGEGVNTEHSFSSLGSYIVTLTVSDGLVIDEHSIELNIKSLVPNQAPLASFNTIHDGLALSFNASNSSDPEGDALSYLWSFGDGTSQSGINTYHQYAAHGLYTVTLNVSDGSSNTQIRTELLVTYDGATGQHVANPFLGTTSYINPDYAKFVDASMALESAPHLQAKMAQVKQQATAVWLDRIDAIYGGEINSGRLSLEQHFDNALAQKRVGVPITVSIVVYNLPDRDCAALASNGTLNAAEGGLEIYKHDYIDTIANIAAAPRFEDLRIIAVIEPDSLPNLVTNTRVLKCGIVNSNGTYVEGVQYALSRFSRLDNVYSYLDIAHSGWLGWDTNMRGAIDLYTSVVAGVADGDMSVLDGFISNVANYTPAEEIFLPDPEFDFDGDFMGIKSSSYYEWNPVFDEKDFAQSLHAEFVAKGFPTSLAMLIDTSRNGWGASDRPTSPNEDASNEDQYVMDSKLDRRAHRGNWCNSSGAGIGARPETLPFGSTSVIQAYVWIKPPGESDGTSDASQTTPDEEGKSFDPMCSPEFTTSGGVLTGAMNGAPSAGAWFHEQFKMLVENAHPEL
>NC_014012.1|WP_157608789.1|1019198_1021301_-|cellulase-family-glycosylhydrolase
MVVAATSLIMSSHLLASPQNNDDWLHVEGNKVVDMQGQQVWLTGANWFGLNASERVLHGLWSVNLGDTLKTISERGINILRLPISTELMYEWSQGKTTLPNVNTASNPDLVGKTDLQIFDILLATAKKYGIKILLDAHSAKADNSGHVETMWYKGEITSEIFYSSWEWITARYQDDDTILAMDIENEPHGTPYGDTNFAKWDDSTDENNWKYACETASNRILAINPNLIVMCEGIQSYPIDGENWTSQDKNDYHNNWWGGNLRGVRDHPINLGANQDQLMYSPHDYGPLVFLQDWFYEGFNKDTLYQDVWKDNWMFIHEENIAPLLIGEWGGFMDGGDNEKWMLAIRDLIIEHELHHTFWCINPNSGDTGGLLKNDWVTWDEEKYTLFEPTLWKDDKGQFIGLDHQVTLGGEGHGTNVAEYYASLSPSLSISSPATNANVLTKSEVVINYDKNKLDSVNAYIDAQLVATSETGSITVQAPTTPSSFVVQLIGLDNGELTEVSDTISLNALDVLPASIEITSPSNGESFEQGKNLMVSANFTNAAGFKAHFAGETQIILNGSDAIFAVGTELGTHSVTVTAIDSNQQELTLASSVDISVISPTVSCSLGRQNIWPGGFVLDGILIANSGSETVSNWSADLIFANQVVLGNGWSANYTQIDNHTIQISGANHTQSIAPGQTHSIGFQGSYPASFALPECVIK
>NC_014012.1|WP_013050156.1|1014877_1019014_-|cellulose-binding-domain-containing-protein
MKTRITRIAAIILLSGSMSQAQADYDGSNGPGVPDIGWTQGQYLSHIPYGGRMVTFHRGYYYIMGQGSTSLWDISAPETPVMVDEHSYGDNGHRWYKLNTDLFWREYTVPELQGSPYHFLDMSDMLNLVPWSDENVPVPILKSGQLEKWQTLETFPTGTNGGNVHDLRFDDPNLDAGAITSTFSLDNAGVNSSLRFRIGNLMFVTGNGLSVFDIGDPLNIKLLDSIVGSFNQYTTTYHVWRNYVVYLNGNNANEESNNMVMIDFSDPSDLKYAGGVPFAKSPGRYMYFQDKYGFAGSDDYGVKLNMETLEVEQVFDAPGQWPDTFLDFQWMPLGPILSISGSNGGKGKTFFYAHQDGPDIKGPEIGFHHPFANSTNMPVTSVIGFVINEILEERSLNSDTIVLRKVGSGHVIKGDVVSTSYQTVNFVPKQRLEENSTYKVTLVANGIKDIAGNGVDEYSFLFSTGSLIDDDPAPVIQQIDYGSKDPIIIEQAVTFTATAIDEDNDPLQYRWDFGEGNNQWSGSNSITHTFTQAGLHSVSLQVRDSGENIVTRVQQLVVIESAYGDLPRQSAQMALNSDRQLLAVVNPDNNSLSIIDTNTGTKLAEIPVCQDPVSVTQVNDEFWLACRDANQITILSALTHSVTDTIKLEYGALPIALVSDLEQEHVYAALMGSGNVIKIASRDRQILASNPVGTSPRALALSGDGASLLVTQFISDAEKGEVWQLNSGDLSISNVIELPLDTSSMDTSSSGRGVPNYLASIAIHPSDRSATVVGKKDNIVRGLSRDGMPLTFETSSRSLVAKLDLLSSTEAQHKRVDIDDHALPVAGVYDQYGSYLFLAMQGNNRIIVLNANSGQEITRLDVGLAPQSLLLDHQSKRLYVKNFMDRSVSIVDVSQLLDQVNTKISLLDTIDTVSSETLTAQVLKGKQIFYNAADKRMGSDGYMACANCHMDGEQDGQVWDFTDRGEGLRNTISLKGRAGTAHGRVHWSANFDEIHDFEHDMRGPFSGSGFIPDSLFNQGLVNQALGDKKAGISTDLDALSAYVSSLNRFNPSPYRNADGELTPQAVLGEIVFNQANCASCHSGEAFTDSPLGFSHDVGTLTALSGQRLSGKLAGIDTPTLRDIFSTAPYLHDGSALSLASLFGKDNAHGNTAGLTPEKLEQLVAYLKQVDGTNGPAPVSELSLSLAGLSEGSVIEASEIPLELETNLTGVTRVEYYADGLLVAISQDTPFNSSWTPVELGRHRLQAKAFYNQGLTASLTPEINIEFGANGGCHITYTPTQEWSTGFQVDLLIANTGEAEINGYLLTFTLGDGEALTNGWNGTFTSSENIIEVTNDASLWNGNIPVGGNIGIGFQGNKSNSPLTLPDHFKLNGKKCTSQ
>NC_014012.1|WP_013050155.1|1013487_1014672_-|PD40-domain-containing-protein
MHHIKTKLISKTQAKWIFTALACAYSLLSFPVSSAIYFNAKVGGPVTNIYAIEQQGKLTKLTQNRVWRDLQPSVSKLGELVFMSNRQAEVKVDLNQTSEVFNIYHLDPKSNRITPLTNNMSQDVNPQFSPDGHKLAFIRFIDKKKVLYIMDLESNTELEVLRAEDIFGYSWANTQEVLAIAIKQGDHSQLLSLKLDGLTKKPLLQTRRSADKDDISSTVNNLSNLNSYRDQSEIMTPVWSTDDSQIAFIFHPTKRGEMRQLALYPIDTGVVKLVSPANISVQSPVQWSKDNHSLLYSGLQDYRYYYDEQTQRKTYLGSMQIFMSKLTGSTVQLTQGDHLHRNPVFSPDGRNIAYLYADELGGARHLSLRTMALDGSHSKQIFDRVARQSSLLWR
>NC_014012.1|WP_013050154.1|1012911_1013424_-|AraC-family-transcriptional-regulator
MIFINKLNYISPNEMTSLQVEKNLFISHILAHKIRPVQQDNQDSLSKIDLLRIKKLKQLMEVDKLYLDSELTIEKLASMFDISPRTLSSLINNHLGKNYNEFTNCYRIMAAKSLLESSLNNDLSVIEIMYQSGFNSKATFYKYFKKMVNSSPSSYRKYHKHNKVRGDNNN
>NC_014012.1|WP_083779927.1|1010281_1012735_-|glycoside-hydrolase-family-6-protein
MRGLSVGIGLMGLNMASGYAAVCEYSIDNEWNTGFVAKVSITNDGPDDIQAWQLTWDYAGANRISSSWNVSLTGNNPYSAAGSGWNNNVPAGGNVEFGFQGTKNGEDAEIPLLQGDICTPANSAPLAVATADLTQGEAPLIVTLDATQSTDADNDYNELTFSWSFSDGTSATGDMVSHSFTSVGSHSATVTVSDGNSSSSKTIAIEVLGNHAPVATATVSTPSGKAPLATTFDATASSDVDNDDLTYEWDFGDGTTSSLASPEHTFVANGDYQVNLTVSDGELSDTTVLSIHVGDEILHVENPFSGVSHYVDSVWAAKAAAEPGGEAIANVSTAVWMDRIGAITDGIGLRGHLDEALAQNAGMFMFVVYDLPNRDCAALASNGELRISENGMQRYKEEYIGPIVDIISDPKYASLRIVTIIEVDSLPNLVTNLGIADCAEADGPDGYRDGIRHTLNELGGIPNVYTYLDIAHSGWLGWSSNFGTAIDLVADVITSTDGGWDNLDGFISNSANYTPVVEPYLPDPQLSVGGMPIRSADFFEWNDYFEEKSYVQDWREAMIALGAPESLGMLIDTSRNGWGGAARPTEVSQADDIDVYVDASRVDRRFHRGNWCNQAGGVGFKPWADPYVGIDAFVWVKPPGESDGISDPNFTPDPNDPAKRHDGMCDPEANSHYNAAYKTGSMANAPHAGRWFPEQFAVLLANAYPDVKDPAGPPPPPPPPRDDCPGLDASNPLVISEMGTRNLVDLGCEAPIHVLFSQPIPRNLYVENTDGPFNVELTYDGTTTPVSGHFKSLGLVGVEKVTLMRIDGATTLELRFD
>NC_014012.1|WP_157608657.1|1007349_1010019_+|hypothetical-protein
MNNKNKFIPTIALASIFLTACGSDSSNESTANSQLNLTISGLPVNALAQVEVTGPNNYRTSLTATSTLKDLVPGTYEVSAAEVIVAGSPFRTASVSSSFSLVAGESAAKTLIYGAPQLSIGAISGFGSVYVNGVRYATDDTEFSHNGAADSSESLLSVGKIVKVQALVPVGGDAIAIGVSYSADVIGEIQSIDLAKGVIRVLGQSYFINELTQFENLTFDQLTVGQGIEISAIRDESGQYMASHVELTDSLVSWQILGVVTNLNLDTKVFNLGSLIVDYSGVELDGEFKNGSHVEVSSATGMEADSLVADAIEIQEMELPGARLALEGIVSELNGNEFTVDGRLFSLNSDTEFTQGKREDLHSGVAVSLLADIIEGASPVLEIRIELLNEMEIQGQVESLNAEGFTLAGIEFLVDEFTRYEDDSDLDIRKFSLADITVGDRLEIQAFENEAGLVCREIERENANEADIVELDGAVDAIESPTFSMKGLTVRTSALTQFEDASGNVIGQDEFFAALMVMDQVEVEGTVINGELVALDVEMESEDDNAVELSGKIDSLDSAQSFTVNGHKVITNGNTRFEDGIEANLSLDVVVEIEGSQADDGTILADKIEFSELDDHEIDLQGVIASLGEMNFDLGGLSISFDLDTEFEYGQASDLALGRYLIVEAQLQEDGSLLARDIEFDDEGQLEIEGSVDGFNSVTDFVVNGLKVTTTAATQFENGTQDSLANGKRIEVEGLLEGTSLLVAQVIEFQGPQERELEGSIEQFVSASEFTLAGEAIITDSFTQYDKGRASDLAAGVKVKIQGYLNESGVILAEELEFIHSQQLQVSGAIDSFVSTLEFSVDGQAVLTDETTEFTGDIKIALSAGLKVNVEGYLQEGNILLATIVSAVE
>NC_014012.1|WP_013050150.1|1006659_1006845_+|hypothetical-protein
MFLSNAQRWAQICERQAEIIENLSSTFPERKEFHSDIGINWRRLGEQVSRGESLGTLDNLK
>NC_014012.1|WP_013050149.1|1006106_1006454_-|DUF3634-family-protein
MTPTILKVLFIAIAIFLAYKLIFSGKKGLTIFEMHFKDGRLKSHKGKIPEKFQKDCRALAKSQKLTCAVRCEKLSGAVRLHISANVNQANTQKIRNLFPFEYYDKKPVDNSRQAG
>NC_014012.1|WP_013050148.1|1005869_1006052_+|hypothetical-protein
MKRVVIITALLGISACATNIDFDSDDSAMQDTVEAMQDPMIKNNQHMIEDARRDGRMERD
>NC_014012.1|WP_041419665.1|1025764_1027618_-|RNA-polymerase-sigma-factor-RpoD
MISMEHTPQSQLKLLLAKGKEQGYLTYAEVNDHLPADMVDADQIEDIVQMINDMGIRVYEQAPDADEIMMTEDSTDDDAAEEAAAALATVEAELGRTTDPVRMYMREMGTVELLTREGEIVIAKRIEEGIYTVQASVAEYPPAIASILDQFDRYEAEEVRLSDIISGFIDPNAADIAPTATHIGSDLSQSERDKDDSKDDSKDDDEDEEEEGPKGPDPEESKERFTQLREVHENTLKIIADKGRGHPEATVALFEIGELFKEFRLMPKQFDRLVKNMRATMDKVRVQERLIMKLCVEQAKMPKKNFVKGYTADESSIAWFDTELASKKPYAEGLKMIEPDVRRCRFKLDIIEKETGLAIASIKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATGESLRNATHEVLAGLTAREAKVLRMRFGIDMNTDHTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEILKSFLDE
>NC_014012.1|WP_013050161.1|1027737_1029465_-|DNA-primase
MAIPRDFINELVARIDIVDQIDAKVPLKKAGKNHSACCPFHSEKSPSFTVSRDKQFYHCFGCGAHGNVIDFVMEYDRLDFIDAIEELAGQLGLEVPREQGTGKKRDEGLSRDLYQLMEEASRHFQSQLRQDKDKQKVLDYLEHRGLSEKVIADFNIGFAPEGWDGLLSRYRQSQDSQDKLLTAGMVIENDSGRRYDRFRDRLMFPIRDRRGRVIGFGGRVLGDGTPKYLNSPETPIFHKGYELYGLYELKQRHRDPQRVLIVEGYMDVVALAQFDVDYAVASLGTATTAEQFQLLLRSAKEVICCYDGDRAGVEAAWRALETALPLLKPGNQVKFMFLPQGEDPDTMVRQVGKEAFESQIDDAKALPEFLFETLAKRHGADKGTLAKQAISLIEKVQDTVLQSLLLENLAYKLGMNGADELRRKLGFSSKKQGHTLQNKALKGRGTPLRLAIALLVQHPMLGEGLPVQPALKHIKMAGVDLLIHLLDITRVQVKNSAQLLEQYRDAPQLSTLKKLTRWEHQVADENLQQEFRKTLIWLNNQYIEQRYQELSLKQNHTKEERIQLSKLITVIQGLN
>NC_014012.1|WP_013050162.1|1029568_1030012_-|GatB/YqeY-domain-containing-protein
MSLVDQLKSQMIDAMRAKAKVRLMTIRMALAAVKQIEVDTRETLTDDQAIAVLTKMVKQRRDSIAQYAAAGRDELAAIEAEEIKVLEVFLPQPLTEEEIAVLVDASIQEMGASSMADMGKVMGALKPKVLGRADMAAIGAMIRAKLK
>NC_014012.1|WP_013050163.1|1030018_1030234_-|30S-ribosomal-protein-S21
MPIIKVRENEPFDVALRRFKRSCEKAGILADVRAREYYEKPTTARKRAKAAAVKRLAKKLSRENARRVRLY
>NC_014012.1|WP_013050164.1|1030552_1031566_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MRVLGIETSCDETGIAVYDDELGLLSHTLYSQVKLHADYGGVVPELASRDHVRKVVPLIKQALADANSTMDDIDGVAYTTGPGLVGALLVGACVGRSLAYSWDKPAVGVHHMEGHLLAPMLEDNVPEYPFLALLVSGGHTMMVAVEGIGQYEVLGESVDDAAGEAFDKTAKLMGLDYPGGPRLAKLAEKGETGHYRFPRPMTDKPGLNFSFSGLKTFAANTIAKEPDDEQTRANIALAFEEAVVDTLSIKCRRALKQTDYTRLVIAGGVSANSRLRTSLAEMMKNLGGEVFYPRGEFCTDNGAMIAYAGLQRLKAGHTEDLGVKGMPRWPLDSLPPL
>NC_014012.1|WP_013050165.1|1031670_1032279_-|glycerol-3-phosphate-1-O-acyltransferase-PlsY
MTITVLTLVMMLTAYLAGSISSAVLVCQMRGLPDPRTQGSGNPGATNVLRIGGASSAAMVLLFDMLKGAIPAYLAFRIGVDPVSLGLIAVSACVGHIFPVFFKFKGGKGVATAFGAMAPIGNDFALALITTWIVMVLISRYSSLAAIITAMLAPAYTWYLDDRFIIPVSMLSALIVIRHKDNIHRLLKGEESKVSRKKKDKT
>NC_014012.1|WP_013050166.1|1032563_1032917_+|dihydroneopterin-aldolase
MDRVLIRQLKIETVIGIYEWEKKIHQNLLIDLDMAWDNKPAADTDDYQYALCYETVSNRLIALITEKPIELIETVAEMIASCLMDEFNVPWVKVTVMKPGAVPTAAAVGVEIERGYC
>NC_014012.1|WP_013050167.1|1032917_1033448_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MLSRVYISLGSNIEPERYLKSGLNDLSSHFGQLLLSSVYESEAVGFEGSNFLNMVVGVDTDLSISELVSLFKQIEQDNGRLVGAKKFASRTLDLDLLLYDDMATLDPVELPRAEILTNAFVLWPMAELAPDLVHPLVDISYQTLWDEYDKNQQRLWPIPFSWTQVQADEASMINSL
>NC_014012.1|WP_013050168.1|1033516_1034317_+|undecaprenyl-diphosphate-phosphatase
MDTFQVIVLALIQGLTEFLPISSSAHLILPAQLLGWEDQGLSFDVAVNTGSLCAVIIYFRRELWSMFKAWGGSIFKGEHNDESKLAWWIILATIPAVIVGFAAKDFIATHLRNIEVVATTTIVFGLLLWWADRMTSKGLTEFQVGWKKALIIGVAQAMALIPGTSRSGATITAALMLGLGREAAARFSFLMSVPISLGAAILVTKDLLSSGEVIDYQALTLGIVVSFLAAYACIHVFLKLVSRIGMTPFVVYRLALGALLCVFIFA
>NC_014012.1|WP_013050169.1|1034380_1035337_+|SAM-dependent-methyltransferase
MKSIYLCPVCNQPLLIHEESQGLHCSNKHHFDKSDKGYWVFSLPKKPKLDSRQVMRGKRFLLESGVFSPLVDTLAEMLKPELAHIASDEAIAHLEYDCGEGYYLRAIKSALSEPLQQAGIKLEQHGINEAENALFSAAKIDSEADSDNATGSDSGTASDASSDSSNESASDSSANTEAEEKSTLIVSSLRALPFADASFDLITLIDKQLKGKEPLRVLKQAGYLLQVSPAPRHLWQLKGYIYPDMKEKELQSSEVNGLELLDTQRVTFKLDADGEQALTLLEMTPYAWRANDKIRKKIASGNFEGLEIDFIVTLSKKI

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Crispr_ID: NC_014012_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_4

1497461-1497562

Orphan

Consensus_repeat	Method
TTCATATGTTTTTGGTAATCTTTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014012_4

>merge|NC_014012|4|1497461-1497562|CRISPRCasFinder
TTCATATGTTTTTGGTAATCTTTGGCTGTGATGCTTGTCCAGCCAAGTTTAAAATCTATATGGTTTATTTGTTCTGGTTCATATGTTTTTGGTAATCCTTGG

>NC_014012|4|4|1497461-1497562|CRISPRCasFinder
TTCATATGTTTTTGGTAATCTTTGG	CTGTGATGCTTGTCCAGCCAAGTTTAAAATCTATATGGTTTATTTGTTCTGG
TTCATATGTTTTTGGTAATCCTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_013050575.1\|1500871_1501225_+\|group-1-truncated-hemoglobin	unknown	unknown	gnl\|CDD\|381253
NC_014012.1\|WP_013050562.1\|1485007_1487125_-\|acetyl/propionyl/methylcrotonyl-CoA-carboxylase-subunit-alpha	unknown	unknown	gnl\|CDD\|227111
NC_014012.1\|WP_049791035.1\|1491612_1492656_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NC_014012.1\|WP_041419737.1\|1503437_1504727_+\|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl\|CDD\|366058
NC_014012.1\|WP_013050570.1\|1495225_1496362_-\|alkene-reductase	unknown	unknown	gnl\|CDD\|239243
NC_014012.1\|WP_013050574.1\|1500440_1500617_+\|carbon-storage-regulator	unknown	unknown	gnl\|CDD\|376847
NC_014012.1\|WP_013050576.1\|1501475_1502054_+\|PhnA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377140
NC_014012.1\|WP_013050566.1\|1491022_1491421_-\|MerR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133403
NC_014012.1\|WP_041419735.1\|1492953_1494990_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239241
NC_014012.1\|WP_013050564.1\|1488021_1489629_-\|methylcrotonoyl-CoA-carboxylase	unknown	unknown	gnl\|CDD\|178415
NC_014012.1\|WP_013050577.1\|1502293_1502749_+\|YaiI/YqxD-family-protein	unknown	unknown	gnl\|CDD\|178882
NC_014012.1\|WP_013050589.1\|1507188_1507704_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240042
NC_014012.1\|WP_013050590.1\|1507743_1508454_-\|tRNA-(adenine(22)-N(1))-methyltransferase-TrmK	unknown	unknown	gnl\|CDD\|225258
NC_014012.1\|WP_013050565.1\|1489708_1490878_-\|isovaleryl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173845
NC_014012.1\|WP_013050571.1\|1496463_1497372_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NC_014012.1\|WP_157608661.1\|1504998_1505238_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013050563.1\|1487124_1487964_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|168168
NC_014012.1\|WP_013050573.1\|1499468_1500101_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|179895
NC_014012.1\|WP_157608815.1\|1505372_1505777_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013050561.1\|1484858_1485005_-\|3-methylcrotonoyl-CoA-carboxylase-subunit-alpha	unknown	unknown	gnl\|CDD\|236449

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_013050575.1\|1500871_1501225_+\|group-1-truncated-hemoglobin	gnl\|CDD\|381253	cd00454, TrHb1_N, truncated hemoglobins (TrHbs, 2/2Hb, 2/2 globins); group 1 (N). The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. They are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). Typical of the TrHb1s (N) group is a protein matrix tunnel. It includes a Mycobacterium tuberculosis TrHb1, Mt-trHbN, which is encoded by the glbN gene. Mt-trHbN is expressed during the Mycobacterium stationary phase, and plays a specific defense role against nitrosative stress. The cyanobacterium Synechococcus sp. PCC 7002 TrHb1 GlbN, is constitutively expressed, and likely also protects cells from reactive nitrogen species.	5.30118e-33
NC_014012.1\|WP_013050562.1\|1485007_1487125_-\|acetyl/propionyl/methylcrotonyl-CoA-carboxylase-subunit-alpha	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NC_014012.1\|WP_049791035.1\|1491612_1492656_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	4.184e-20
NC_014012.1\|WP_041419737.1\|1503437_1504727_+\|dicarboxylate/amino-acid:cation-symporter	gnl\|CDD\|366058	pfam00375, SDF, Sodium:dicarboxylate symporter family.	1.62562e-121
NC_014012.1\|WP_013050570.1\|1495225_1496362_-\|alkene-reductase	gnl\|CDD\|239243	cd02933, OYE_like_FMN, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include 12-oxophytodienoate reductase, pentaerythritol tetranitrate reductase, morphinone reductase, and related enzymes.	2.63858e-177
NC_014012.1\|WP_013050574.1\|1500440_1500617_+\|carbon-storage-regulator	gnl\|CDD\|376847	pfam02599, CsrA, Global regulator protein family. This is a family of global regulator proteins. This protein is a RNA-binding protein and a global regulator of carbohydrate metabolism genes facilitating mRNA decay. In E. coli CsrA binds the CsrB RNA molecule to form the Csr regulatory system which has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis. In other bacteria such as Erwinia caratovara RmsA has been shown to regulate the production of virulence determinants, such extracellular enzymes. RmsA binds to RmsB regulatory RNA.	6.48424e-07
NC_014012.1\|WP_013050576.1\|1501475_1502054_+\|PhnA-domain-containing-protein	gnl\|CDD\|377140	pfam03831, PhnA, PhnA domain.	4.05761e-30
NC_014012.1\|WP_013050566.1\|1491022_1491421_-\|MerR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|133403	cd04776, HTH_GnyR, Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR. Putative helix-turn-helix (HTH) regulatory protein, GnyR, and other related proteins. GnyR belongs to the gnyRDBHAL cluster, which is involved in acyclic isoprenoid degradation in Pseudomonas aeruginosa. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	1.42884e-56
NC_014012.1\|WP_041419735.1\|1492953_1494990_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|239241	cd02931, ER_like_FMN, Enoate reductase (ER)-like FMN-binding domain. Enoate reductase catalyzes the NADH-dependent reduction of carbon-carbon double bonds of several molecules, including nonactivated 2-enoates, alpha,beta-unsaturated aldehydes, cyclic ketones, and methylketones. ERs are similar to 2,4-dienoyl-CoA reductase from E. coli and to the old yellow enzyme from Saccharomyces cerevisiae.	0
NC_014012.1\|WP_013050564.1\|1488021_1489629_-\|methylcrotonoyl-CoA-carboxylase	gnl\|CDD\|178415	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain.	0
NC_014012.1\|WP_013050577.1\|1502293_1502749_+\|YaiI/YqxD-family-protein	gnl\|CDD\|178882	PRK00124, PRK00124, YaiI/YqxD family protein.	1.38336e-70
NC_014012.1\|WP_013050589.1\|1507188_1507704_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240042	cd04686, Nudix_Hydrolase_27, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.41267e-63
NC_014012.1\|WP_013050590.1\|1507743_1508454_-\|tRNA-(adenine(22)-N(1))-methyltransferase-TrmK	gnl\|CDD\|225258	COG2384, COG2384, Predicted SAM-dependent methyltransferase [General function prediction only].	2.02892e-29
NC_014012.1\|WP_013050565.1\|1489708_1490878_-\|isovaleryl-CoA-dehydrogenase	gnl\|CDD\|173845	cd01156, IVD, Isovaleryl-CoA dehydrogenase. Isovaleryl-CoA dehydrogenase (IVD) is an is an acyl-CoA dehydrogenase, which catalyzes the third step in leucine catabolism, the conversion of isovaleryl-CoA (3-methylbutyryl-CoA) into 3-methylcrotonyl-CoA. IVD is a homotetramer and has the greatest affinity for small branched chain substrates.	0
NC_014012.1\|WP_013050571.1\|1496463_1497372_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.5195e-74
NC_014012.1\|WP_013050563.1\|1487124_1487964_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|168168	PRK05674, PRK05674, gamma-carboxygeranoyl-CoA hydratase; Validated.	3.3496e-98
NC_014012.1\|WP_013050573.1\|1499468_1500101_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|179895	PRK04930, PRK04930, glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional.	2.55444e-60
NC_014012.1\|WP_013050561.1\|1484858_1485005_-\|3-methylcrotonoyl-CoA-carboxylase-subunit-alpha	gnl\|CDD\|236449	PRK09282, PRK09282, pyruvate carboxylase subunit B; Validated.	0.000890912

>NC_014012.1|WP_013050571.1|1496463_1497372_+|LysR-family-transcriptional-regulator
MLDKLPNLRSFMAVAEANSFAKAARKLNMANSSVSRQIAQLESQLNVSLFTRTTRHVQLSPAGEILYGRASGLIMEMENLAAELSAENVTPHGTLKVSVPWWFSQLHLAPLLPEFLALYPDLRVVMQCDDGMTKLVEEGFDVAVRLSRLKDSNLIARRLGPHSFAMAASPEYLARHAEVIKPEDLREHAMLSFNFSTPYHSWTLRKQGKSYRIPLKDSVLTSNNADILKQCALDGAGIIIQPVWGIQAEIESGALIQLLPDFEVTSTTFDNGIFAVYSKESKAVNRVKVFVDFLTERLKVAG
>NC_014012.1|WP_013050570.1|1495225_1496362_-|alkene-reductase
MKYPALFDTATLGSLTLENRIVLPPLTRSRSSQPGNIANELMAKYYSQRSGAGFMITEGTQIEPRGQGYAWTPGIHSPEQVEGWRKVTQAIHDQGKVIFAQLWHVGRVSHTSLQPGNAAPIAPSAGKADTVSVFIETGPGEGALAEPSPARALSTQEVKELVQLYKQAAVNAKDAGFDGIEIHSANGYLVNQFISDKSNFRQDEYGGSLENRLRFLKEIVEAVTQVFSPERVGVRFAPMFETTQEDRIYLGLLEDDPHTTYVTAIKMLEQAKLGYLSLAEADWDNAPELPDSFRQAVRDSFSGLIIYAGRYTPERGQRLLEKNLGDLIAFGRPFIANPDLPERIRHDLPLNAVDPTTMYGGTDLGYTDYPTADMPQTN
>NC_014012.1|WP_041419735.1|1492953_1494990_+|FAD-dependent-oxidoreductase
MLKQEHRVLFESMQIGQLKLKNRYSMAPMGTLGCVDGDGAYNKRGQDYYIARARGGVGLIITGVQMVENELEQFPMPSLPCPTVNPVAYVRSAREMTERIHSYGTKIFAQLTAGWGRSCIPGFTPLDKSIAPSAAPNRFDPSIEHRELTTEEVKYFISKFVESAAIAQKAGFDGVEIHAVHEGYLLDQFTMKFFNKRTDEYGGSFENRYRFAVEIVEGIKAVCGKHFPVSLRYSVKGNMKAYGQGILPGEEAEEVGRDMEEGLKAAKYLQDAGYDALNVDAGTYDSWYWNHPPNYFQPGMYKPYCKAVSEVVDIPVLMAGRMENPDLASHAVENGICDGISMGRPLLADPEVVNKIRRGRFEEVRPCLSCHLGCLGRMAEVGNISCAVNPSCGREEEYALTPAFKPKKVVVIGGGVGGMEAARIASERGHSVILMEKASELGGNVIPGGQPPFKHDDKQLVVWYSGEMERKAVEVRMNTLATKENIEAENADVVIFATGSRPTQPAWLKGADKPHVMTAEKMLMNPELITGDKLTVIGGGLVGSEAALWMAQRGKSVTLIEASDDLIGGPHKTCFANYQMLKELLEFENVDVKTSTYLDFITDTGIMMHSAQAADGAELQELESDHVVLAMGYKAEHGLFDELANELDVDEVFNIGDSQQARTIMTAIWDGYEVARSL
>NC_014012.1|WP_049791035.1|1491612_1492656_-|helix-turn-helix-transcriptional-regulator
MKIDPNRVIHKGWLTLFLDNLDELELGDITELERSMRDTLALADDNHFYIETKKMKHFIYEIYESLGSGLFFTQVADNISPLTFGNYSLVLWTSPTVREMLENLCEYSIFLGSTTRMKLIENSQGDLEILFITNETLNIQPLTYLGQAYFVSLIIKLLLKLCPQMANTIKLKVHDFPFDNKQVFNFEKQLNCVLSLNSPIMKIIISQHFLNFPIATSDPDIYPSLVLILKNWVVKIQSEDILLRIYDVFEQFPRLSDASNQKVADGLMMSVRTLNRRLSEINTSYRNVVEKYKLEKALFLLKQQRVNMTEIAFQLGFADLSSFSRAFKRWTGLSPSNVHSKQRKPLA
>NC_014012.1|WP_013050566.1|1491022_1491421_-|MerR-family-DNA-binding-transcriptional-regulator
MTENQSPQTNYSISDLSKEFDITTRSIRFYEDQGLLKPKRRGQTRIYVLKDRVRLKLILRGKRLGFSLAETRRLFELYDADKNSSSQLQTMLDLVEDKKSSLQQQMDDIKVVLMELNSAEQQCRSALALQEK
>NC_014012.1|WP_013050565.1|1489708_1490878_-|isovaleryl-CoA-dehydrogenase
MTQLYSSLNFGLGEDIDMLRDAVQNFAANEIAPIAAKTDSDNEFPNELWPVLGDMGLLGVTVSEEYGGADMGYLAHVVAMEEISRASASIGLSYGAHSNLCVNQINRNGNAEQKAKYLPKLVTGEHVGALAMSEPNAGSDVVSMKLHARKEGDRYILNGNKMWITNGPDAQTYVIYAKTDLDKGAHGITAFIVDRDSKGFSTAQKLDKLGMRGSNTCELVFQDCEVPAENILGGLNNGIKVLMSGLDYERVVLSGGPLGIMNACMDIVIPYVHEREQFGKSIGQFQLVQGKLADMYTGMNAAKSYIYNVAKSCDRGETTRKDAAGAILYSAELATKMALDAIQLLGGNGYVNEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFNESK
>NC_014012.1|WP_013050564.1|1488021_1489629_-|methylcrotonoyl-CoA-carboxylase
MTQLSSRINSRSDEFKAKHDDMLALVQDLKLKLQQIEQGGGEVARQRHLSRGKLLPRQRVEKLLDPGSPFLELSQFAAYELYEDVIPAAGVIAGIGRVSGIECMIIANDATVKGGTYYPVTVKKHLRAQEIASRCHLPCIYLVDSGGAYLPRQDEVFPDRDHFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKEQGTIFLAGPPLVKAATGEEVTAEELGGAEVHTKISGVADHLAQNDDHALELARKAVTRLNHQKTIAAQLSPVKPPKFDINELYGIVGTDLKKPYDVREVIARVVDDSDFDEFKANYGNTLVCGFARIHGYPIGIIANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVMAVSCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVKRDGLARKGVQWSDDEEQKFRAPIVEQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEETKFGVFRM
>NC_014012.1|WP_013050563.1|1487124_1487964_-|enoyl-CoA-hydratase/isomerase-family-protein
MTTQLIENFKYVSCQLSNGVGQMVLNRAEKHNAFDEVMIAEMIQTLEHFAHNDECQVLVLKANGKNFSAGADLDWMRKQAKMDFEQNLADANELAKLMSTLDKFPKPTIALVQGAAFGGALGLICCCDIAIANERASFCLSEVKLGLIPAVISPYVVRAMGQRASRRYMLTAERFTAEKARDLQVIHEINDDLEAAAKPIIQALLANSPQGMAWVKTLLSRLEDGVIDDATLSYTSERIAKIRVSNEGQEGLNAFFDKRKPNWISAQNDSKNISAQGAK
>NC_014012.1|WP_013050562.1|1485007_1487125_-|acetyl/propionyl/methylcrotonyl-CoA-carboxylase-subunit-alpha
MFSQSLIKKLLIANRGEIACRIIKTAKAMGVRTVALYSDADVHARHVALADESFYLGGSAPADSYLKADLIIDIAKKSGAQAIHPGYGFLSENAEFARKCEQAGIIFVGPTADAIDSMGSKSAAKDIMGAANVPLVPGYHGDAQDDALLVKEANKMGFPLLIKATYGGGGKGMRIVESSAEVLENIHSARREASSSFGNDKLLMERYLRQPRHVEVQVFADNYGNCIYLSDRDCSIQRRHQKVVEEAPAPGLSDELRAEMGEAAVAAAKAIDYRGAGTIEFLLDTDNSFYFMEMNTRLQVEHPVTEMVTGQDLVKWQLMIASGSHLPLKQDEVRIHGHSFEVRIYAEDPQNDFLPASGKLNFLREPEQSKFVRIDSGIRENDVISNFYDPMISKLIVWDETRPRALQRMVHSLESYQISGLKHNIEFLANITEHKAFRDANFSTDFIERYGDELIGRSPLLSQESASNHEQNALALAALYQLCARKVAAKESAVNSHDPYSPWGTVSGFRLNSSSTHQVSLLDDKHQVHHLAVSEVMIAGQSVYQVQIDDKAYVLKGDLIDEMLHAEIAVKDEHDKTSAIKASGHKVKVPVSQVEQDFTLFINATSYHYRAIQTELVEEQECLADKLKAPMNGTIVTHLVTKGDAVTAGQGLMVMEAMKMEYTIESPFDGLVSAFFFEPGELVTDGTILVEVEPAASEEKAEGKA
>NC_014012.1|WP_013050561.1|1484858_1485005_-|3-methylcrotonoyl-CoA-carboxylase-subunit-alpha
MTHVIDAIESPFDGLVSAFFFEPGELVTDGTILVEVEPLEPTETEGKA
>NC_014012.1|WP_013050573.1|1499468_1500101_-|NAD(P)H-dependent-oxidoreductase
MPEERKKILVLFAHPSQERSEVNKLLFKASQEHSDVTAIDLYREYPTFHINIDREQQRLLDHQVIIFLFPLHWYSTPAILKQWQDLVLEYGFAYGADGVALKGKTFFCATTAGGNEKAYQGDGYNHFTIRELLYPIEQTANLTGMHYLAPFVLFSSRNASEEGRIPGHIDAFNALLTSLATNTLDLSHAASLPVLNQAHVHQSEQASQTL
>NC_014012.1|WP_013050574.1|1500440_1500617_+|carbon-storage-regulator
MLILTRKPNSSITITNIYDENGHKLQDIEINVYADNRIGIIADGSVDIYRSEILELGD
>NC_014012.1|WP_013050575.1|1500871_1501225_+|group-1-truncated-hemoglobin
MSLYDRLGGENKIARIAADIFDTHATNPTVASRYKDSNREQVIKMVTEFLCAGTGGPQDYTGKSMPEAHRCMNINEVEYLAVIDDIMVALDKNEVGSQEKQELLMIAYSLKGEIIGA
>NC_014012.1|WP_013050576.1|1501475_1502054_+|PhnA-domain-containing-protein
MTRELLKRCDNKCELCSSESKLASYELPDSKGYGDARIMICDTCTGQIQDRSTIDMNHWRCLNDSMWSQVPAVQVMAYRMLKQISEEAWARDLLDMLYLDDDMQAWGDAGIEEVDEDFVPHRDSNGAIIEAGDNVVIIKDLNVKGTTFTAKRGTTVRGISLTNNPEHIEGRVNGTRIVILTCYVKKVPLSEE
>NC_014012.1|WP_013050577.1|1502293_1502749_+|YaiI/YqxD-family-protein
MKIWVDADACPGVIKETLFRAADRAKVEVTLVANHSMRIPPSRFIKMVIVSSGFDVADDEIVKRLDAGDLVITADIPLASEVIDKGGVALNPRGELYTDQNIKAILNMRDFMDTMRSSGVQTGGPAALGQSDRQAFANQLDRFITKHHKPD
>NC_014012.1|WP_041419737.1|1503437_1504727_+|dicarboxylate/amino-acid:cation-symporter
MKLHWQIMIAIVIAIFIGLLTPPSSQIYQVYGFFGTLFLNALKMVIVPLIMASIISSMASLNQGDNLGRLGLKTLGYYATTSLIAILIGLTVVNITSPGIIDGAPAGELLNLHADSAELESTLMKVEGRGSKDLIEIFIRMIPTNIVAAAAEGQMLGLIFFSLLFGFFMGRVEGRRGEVLRDFWKGVSKTMVLITQFVLKFAPIGIFALIAKTVSATGFNAFAPMLVFLLTVITALALHAFVALPLLLKFVGGVSPLKQLSVMSPAMLMAFSTASSSATLPLTMECVKKRAGVSHKTASFVLPLGATVNMDGTALYECVAAMFIAQAYGLELGLVTQFTIVLVALLTSIGVAGIPAASLVAITVILAAIGLPLEAIGLLLVTDRILDMMRTAVNVYSDACGTVIIARTEGESWVLSPEQDHEVTEPDND
>NC_014012.1|WP_157608661.1|1504998_1505238_-|hypothetical-protein
MGHQMPESWLHHHFSLIVTIQNQDSASVLIGSKMSTNSCTKGDSISPLARFVLTASFRHCIFHNARLKDLNSLSSQTLA
>NC_014012.1|WP_157608815.1|1505372_1505777_+|hypothetical-protein
MLTALVGFNSASANDTAHDETASDVFSVDRIVSNDVELKFTNDGDIQPKISEFIVVNYVLMSNEKGDRRAVVTLENQSSGSRIFKSDQVMALMGDGRRLSPHTYKQKFKRGESISMTLLFGNNKSPILQIYTRQ
>NC_014012.1|WP_013050589.1|1507188_1507704_-|NUDIX-domain-containing-protein
MRHLTSTTHPKLSSLEGKTFHRKAARGIILDGENILMLYTERYHDYSIPGGGIDAGEAIETGLLRELEEETGAQHIEIIGEFGIYEEFRPWYKEDFDIIHMESYCYVCNIHPELGATKLEEHEIQNGMTPVWLNIFEAIKHNEHTIANSPKKGMSIERETYLLKRIVEELL
>NC_014012.1|WP_013050590.1|1507743_1508454_-|tRNA-(adenine(22)-N(1))-methyltransferase-TrmK
MKLSQRLSLIDKMVDGEYDHIWDCCCDHGLLGTRLLKRGAAKTIHFVDVVEDLMLALESKLQRFSPANIQQAKPRWQVHYLDVAKLPLAQYGHSQRHLIIIAGIGGDLLIELVSKILTDYPDKKLEFILCPVHHNYKVRSQVSKLKLGLVHECLIKENKRFYEVMHLSTLSSTPVSLVGSQMWDLSRDDDRYYLTKTLAHYRRMQQNAPTNDAEIEQIISQYQAVNELSIQHKLHG

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Crispr_ID: NC_014012_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_5

1551640-1551850

Orphan

I-F

Consensus_repeat	Method
CATGTTCACTGCCGCACAGGCAGCTTAGAAA	PILER-CR
GTTCACTGCCGCACAGGCAGCTTAGA	CRISPRCasFinder
GTTCACTGCCGCACAGGCAGCTTAGAAA	CRT

3 spacers

WYL

The CRISPR arrays of NC_014012_5

>merge|NC_014012|5|1551640-1551850|PILER-CR,CRISPRCasFinder,CRT
CATGTTCACTGCCGCACAGGCAGCTTAGAAAAATGATAAAGGCTATGTTCAGTGCACTATCAGGTTCACTGCCGCACAGGCAGCTTAGAAATCAGAGGGTTCAACAATGCCAGTAATGAACATGTTCACTGCCGCACAGGCAGCTTAGAAATCTATGGCATCGAGTTGGGATTGAATATCGTGGTTCACTGCCGCACAGGCAACTTAGAGA

>NC_014012|5|1|1551640-1551790|PILER-CR
CATGTTCACTGCCGCACAGGCAGCTTAGAAA	AATGATAAAGGCTATGTTCAGTGCACTAT
CAGGTTCACTGCCGCACAGGCAGCTTAGAAA	TCAGAGGGTTCAACAATGCCAGTAATGAA
CATGTTCACTGCCGCACAGGCAGCTTAGAAA

>NC_014012|5|5|1551643-1551848|CRISPRCasFinder
GTTCACTGCCGCACAGGCAGCTTAGA	AAAATGATAAAGGCTATGTTCAGTGCACTATCAG
GTTCACTGCCGCACAGGCAGCTTAGA	AATCAGAGGGTTCAACAATGCCAGTAATGAACAT
GTTCACTGCCGCACAGGCAGCTTAGA	AATCTATGGCATCGAGTTGGGATTGAATATCGTG
GTTCACTGCCGCACAGGCAACTTAGA

>NC_014012|5|1|1551643-1551850|CRT
GTTCACTGCCGCACAGGCAGCTTAGAAA	AATGATAAAGGCTATGTTCAGTGCACTATCAG
GTTCACTGCCGCACAGGCAGCTTAGAAA	TCAGAGGGTTCAACAATGCCAGTAATGAACAT
GTTCACTGCCGCACAGGCAGCTTAGAAA	TCTATGGCATCGAGTTGGGATTGAATATCGTG
GTTCACTGCCGCACAGGCAACTTAGAGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_013050623.1\|1540952_1542098_-\|cell-division-protein-FtsZ	unknown	unknown	gnl\|CDD\|276961
NC_014012.1\|WP_013050645.1\|1562254_1563079_-\|zinc-dependent-peptidase	unknown	unknown	gnl\|CDD\|377621
NC_014012.1\|WP_013050634.1\|1552760_1553258_-\|SsrA-binding-protein-SmpB	unknown	unknown	gnl\|CDD\|235455
NC_014012.1\|WP_013050626.1\|1545205_1546735_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|184118
NC_014012.1\|WP_013050622.1\|1540309_1540498_+\|AlpA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225848
NC_014012.1\|WP_013050640.1\|1555463_1556285_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|381179
NC_014012.1\|WP_013050625.1\|1543639_1545115_+\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226350
NC_014012.1\|WP_013050644.1\|1561512_1562106_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379209
NC_014012.1\|WP_041419743.1\|1546727_1548308_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|236815
NC_014012.1\|WP_013050629.1\|1549073_1549268_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NC_014012.1\|WP_013050632.1\|1550420_1551398_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013050637.1\|1554063_1554396_+\|RnfH-family-protein	unknown	unknown	gnl\|CDD\|377094
NC_014012.1\|WP_013050628.1\|1548324_1548858_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376158
NC_014012.1\|WP_083779930.1\|1556841_1558557_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_014012.1\|WP_013050636.1\|1553557_1553989_+\|ubiquinone-binding-protein	unknown	unknown	gnl\|CDD\|182678
NC_014012.1\|WP_013050641.1\|1556406_1556616_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153390
NC_014012.1\|WP_013050624.1\|1542151_1543159_-\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_014012.1\|WP_041420239.1\|1554468_1554984_-\|outer-membrane-protein-assembly-factor-BamE	unknown	unknown	gnl\|CDD\|225465
NC_014012.1\|WP_013050630.1\|1549264_1549672_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_041420241.1\|1559968_1561429_+\|HDOD-domain-containing-protein	unknown	unknown	gnl\|CDD\|370050

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_013050623.1\|1540952_1542098_-\|cell-division-protein-FtsZ	gnl\|CDD\|276961	cd02201, FtsZ_type1, Filamenting temperature sensitive mutant Z, type 1. FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells.	1.90614e-124
NC_014012.1\|WP_013050645.1\|1562254_1563079_-\|zinc-dependent-peptidase	gnl\|CDD\|377621	pfam06167, Peptidase_M90, Glucose-regulated metallo-peptidase M90. MtfA (earlier known as YeeI) is a transcription factor A that binds Mlc (make large colonies), itself a repressor of glucose and hence a protein important in regulation of the phosphoenolpyruvate:glucose-phosphotransferase (ptsG) system, the major glucose transporter in E.coli. Mlc is a repressor of ptsG, and MtfA is found to bind and inactivate Mlc with high affinity. The membrane-bound protein EIICBGlc encoded by the ptsG gene is the major glucose transporter in Escherichia coli. MtfA is found to be a glucose-regulated peptidase, whose activity is regulated by binding to Mlc available in the cytoplasm, which in turn has been released from EIICBGlc during times when no glucose is taken up. A physiologically relevant target for this peptidase is not yet known.	1.73916e-125
NC_014012.1\|WP_013050634.1\|1552760_1553258_-\|SsrA-binding-protein-SmpB	gnl\|CDD\|235455	PRK05422, smpB, SsrA-binding protein SmpB.	7.00792e-82
NC_014012.1\|WP_013050626.1\|1545205_1546735_+\|AAA-family-ATPase	gnl\|CDD\|184118	PRK13531, PRK13531, regulatory ATPase RavA; Provisional.	1.12901e-81
NC_014012.1\|WP_013050622.1\|1540309_1540498_+\|AlpA-family-transcriptional-regulator	gnl\|CDD\|225848	COG3311, AlpA, Predicted transcriptional regulator [Transcription].	8.51099e-21
NC_014012.1\|WP_013050640.1\|1555463_1556285_+\|hypothetical-protein	gnl\|CDD\|381179	cd19916, OphMA_like, tetrapyrrole methylase family protein similar to Omphalotus olearius omphalotin methyltransferase (OphMA) and Dendrothele bispora dbOphMA. OphMA, is the precursor protein of the fungal cyclic peptide Omphalotin A. Omphalotin A is a potent nematicide, having 9 out of 12 of its residues methylated at the backbone amide. Omphalotin A derives from the C-terminus of OphMA (also known as OphA). OphMA catalyzes the automethylation of its own C-terminus using S-adenosyl methionine (SAM); this C terminus is subsequently released and macrocyclized by the protease OphP to give Omphalotin A.	1.24938e-131
NC_014012.1\|WP_013050625.1\|1543639_1545115_+\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|226350	COG3829, RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms].	1.38211e-108
NC_014012.1\|WP_013050644.1\|1561512_1562106_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379209	pfam13474, SnoaL_3, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	3.85531e-28
NC_014012.1\|WP_041419743.1\|1546727_1548308_+\|VWA-domain-containing-protein	gnl\|CDD\|236815	PRK10997, yieM, ATPase RavA stimulator ViaA.	1.76716e-46
NC_014012.1\|WP_013050629.1\|1549073_1549268_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	9.01927e-18
NC_014012.1\|WP_013050637.1\|1554063_1554396_+\|RnfH-family-protein	gnl\|CDD\|377094	pfam03658, Ub-RnfH, RnfH family Ubiquitin. A member of the RnfH family of the ubiquitin superfamily. Members of this family strongly co-occur in two distinct gene neighborhood contexts. In one it is associated with a START domain protein, a membrane protein SmpA and the transfer mRNA binding protein SmpB. This association suggests a possible role in the SmpB-tmRNA-based tagging and degadation system of bacteria, which is interesting given that other members of the ubiquitin system are analogously involved in protein-tagging and degradation across eukaryotes and various prokaryotes. The second context in which the RnfH genes are present is in a membrane associated complex involved in transporting electrons for various reductive reactions such as nitrogen fixation.	1.13443e-39
NC_014012.1\|WP_013050628.1\|1548324_1548858_+\|hypothetical-protein	gnl\|CDD\|376158	pfam18735, HEPN_RiboL-PSP, RiboL-PSP-HEPN. RiboL-PSP-HEPN. Fused to endoRNase L-PSP ; in operon with ParB.	9.34685e-14
NC_014012.1\|WP_083779930.1\|1556841_1558557_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.08091e-57
NC_014012.1\|WP_013050636.1\|1553557_1553989_+\|ubiquinone-binding-protein	gnl\|CDD\|182678	PRK10724, PRK10724, type II toxin-antitoxin system RatA family toxin.	1.41978e-68
NC_014012.1\|WP_013050641.1\|1556406_1556616_+\|hypothetical-protein	gnl\|CDD\|153390	cd07321, Extradiol_Dioxygenase_3A_like, Subunit A of Class III extradiol dioxygenases. Extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into substrates using a variety of reaction mechanisms, resulting in the cleavage of aromatic rings. There are two major groups of dioxygenases according to the cleavage site of the aromatic ring. Intradiol enzymes cleave the aromatic ring between two hydroxyl groups, whereas extradiol enzymes cleave the aromatic ring between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Extradiol dioxygenases can be divided into three classes. Class I and II enzymes are evolutionary related and show sequence similarity, with the two domain class II enzymes evolving from the class I enzyme through gene duplication. Class III enzymes are different in sequence and structure and usually have two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. This model represents subunit A of class III extradiol dioxygenase enzymes. The A subunit is the smaller, non-catalytic subunit. Enzymes that belong to this family include Protocatechuate 4,5-dioxygenase (LigAB) A subunit, 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase (CarB) A subunit, Gallate Dioxygenase and proteins of unknown function.	4.32979e-07
NC_014012.1\|WP_013050624.1\|1542151_1543159_-\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	3.86749e-11
NC_014012.1\|WP_041420239.1\|1554468_1554984_-\|outer-membrane-protein-assembly-factor-BamE	gnl\|CDD\|225465	COG2913, OlmA, Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane].	7.34631e-29
NC_014012.1\|WP_041420241.1\|1559968_1561429_+\|HDOD-domain-containing-protein	gnl\|CDD\|370050	pfam08668, HDOD, HDOD domain.	5.26679e-20

>NC_014012.1|WP_013050632.1|1550420_1551398_+|hypothetical-protein
MPRPRRTQISIEDTPWYHTVSRCVRKAWLTGVDPNTGQSYEHRRDWVESQLLKLADIFAIDIAAYVVMSNHLHLVLRIDIELANSWTDREVVEQWHQLFKGTELTQRFAKGELVEELNLSQLRHSIADYRSRLSDISWFMRCLNEPIARMANKEDKCTGRFWEGRFKSQALLDEAAVLTCMAYVDLNPIRAKMAQTPDKSDYTSIQARIKAALIGEQPQSLVPFIGGERFNQPKGINFSLQDYLQLVDEMGRILREDKRGSISVSSSKILKTLNISTGNWIKLTSEFGKIFHGPVGTTQELTNYCEHLQKRRRHFAKCCRYLEDG
>NC_014012.1|WP_013050630.1|1549264_1549672_+|hypothetical-protein
MTSEDNLVSLGFKFGKNGAHSARSMMIEELSLLFLSCSENATQVDFEKDIVDFNILHKPTEKSRKLTFRHLVDLYSLDLDVPLFNVLRQWWELDEKAQPVLALQLAVARDPILRGSVPVILGLEAGEHLSRQTVK
>NC_014012.1|WP_013050629.1|1549073_1549268_+|helix-turn-helix-domain-containing-protein
MTDQILTLKEVAAYLKLTDKTAYRLASEGKLPGFKVGGSWRFKREDLEAWIEDNKTKVNGESSK
>NC_014012.1|WP_013050628.1|1548324_1548858_+|hypothetical-protein
MSKAKDNFENAIQDSERILQAYDQLNQIEGREREPEELKRAALIMTLTAWETYVEDIIEERLTADLRTLEGSKVASFITSTLERELRYFHTPNSKNTKGMFERYLHLDVTEAWTWIDGDAEQVKSKLNQWIKKRGEAVHRSVSDKQAAHLVNRQDMNKCLTFFKKLVETTNSALDGV
>NC_014012.1|WP_041419743.1|1546727_1548308_+|VWA-domain-containing-protein
MSEPKPTMAKHKVGLLAQFDQQFSAIDLLPKELMPAVVTLPGGDLTSRCQSIALLRTQLLTAEELSLPCPWLPEVIQQQIITSIKASGIARYCKNNPIVTDALLTDLLIKLEGAQLQALAISQQMAIIAENKAIEQLRLELEAIQKKRSSTKKKKFLALNDAQRLDIKVKAELNAWIQLATGAGGQLFELPDIWSQRREIWQELEGVFTDLGLVTGLGWDLSQGIFQSHGWMNLVRLQKIVKQIPQLREVIETLGRMKDTEGDPIIEEIISRMSVTFRHEVEVITPLVPMETKGITRSDSISRMLPQEAAFFGHPVLKKLWHVRRAEHALLSYAVEGTELITEVTEQEQEFKESKAGKKLNRNRGPMIVCLDTSGSMSGTPENVAKALVLQCISVAKKEKRACFVYLFGSKGEVKEMELTPDKAGLEQMILFLSMSFGGGTDVEGPLNMALERSDEKQWLRADILLVSDGEFSVSSGLSRKIKHRKEQRAMSVHGVVIGGSLSPMDKICEPLHQFSSWLYLQNNKH
>NC_014012.1|WP_013050626.1|1545205_1546735_+|AAA-family-ATPase
MNNLTSIALLSRKEKIVRLIDEMNKGLLERNEQVKLMLLAALAGEHVLLIGPPGTAKSELAKRLKSVFVEASYFERLLTRFSVPEELYGPLSIQALEDDKYKRLTSGYLPEASVAFIDEIFKANSAILNSLLTLLNEREFDNGNRRYKVPLISVVAASNELPEGEELSALYDRFMLRSFVAPVSNESFQDLLMLSGSTCDPELEVRLKLEDLAEVQQLSEKVLLNPSVIVLCKAFREHLQREDIYVSDRRWRKVIKLMKVSAFTTGMTEVSNYDAWILPHCLWNKPEELQGLKEVYEQAVAINGEFSHERLTSLVSIWDNKLQADKSQQRQKQDAKGRPLFINDKGNETIKSSGEVQKTDSSGNLIYVDKHYNKETVEKTNGYSGSNDPVIIEVSFKATTESVHYSKSHIQGRLQEVGELKNTAQSHIDALNNQLDSANATFNDHIWLDKTLLPQITASLENARSHTQKQLSKINKLEVGFTALPKEDESIYIDSDVAEDTALEGELCE
>NC_014012.1|WP_013050625.1|1543639_1545115_+|sigma-54-interacting-transcriptional-regulator
MNKQRLLVSWIGGNDLNMPEGQMTGPIWATIKSAKFDGIELIYNYSDDEVRPYVSLLSERVKCKINTRKANLSSPIDYEDIYIAAEQLLKDVVHPESDLSILLSPGTPAMQAIWVLLGKTRFPCTFYQASKEQGVEAVKIPFKLYAEYVPAVTQLNQSELNNLAQLEAPIDSAFDDIITNGTDIQTLKYQAQILAQQEVPVLICGESGTGKEMFARAIHNASVRKDKPFIAVNCGAFPSELIDSILFGHKRGAFTGAVSDKAGVFEQAHNGTLFLDEFGELEPAVQVRLLRVLQDGKYTRLGDSDEQSSNFRLITATNKNLISEVAHGRFREDLFYRVAIGVLQLPPLRLRQGDLDFLVDSLMQTVVKEHPVLQGKNISHLAKEIIKQHKWPGNIRELKATLLRAALWSSSDCIDEAEMRQALFIMEGKQESLLDRDIQQDFDINDILSEVESHYIVKALEQADGNKSKVAKLLGYNNHQTLSNRLKKLGI
>NC_014012.1|WP_013050624.1|1542151_1543159_-|WYL-domain-containing-protein
MQINIQRQIAMLEQIPRHPSRITANDVTDRLQNRDYDVGLRTVQRELKAMHDMGLFGLVLDDRSKPFGWSIAACWRGLNLTLMDNHMALAFHTLKHSASELLPPQSLKQLTPYFERADQVLGSDPDNPWLYWACRVAQLPKPFPFIIAEQDPQIFETVQYALLHKRQMACQIKRVIKGESYWIDYSPINPEGIQISDGVALLTFTIGKFDSKLYAKSIDLLRNVRLLDTPSITRSDLDIARSQNKSASELIDIELLFSPSANFIMRNAKLSENQSVQQLEDGRYRVNARVRDSSGLRTFLWNMADNVEVVAPLKLRTHFIRLLNKVNARYQNTAT
>NC_014012.1|WP_013050623.1|1540952_1542098_-|cell-division-protein-FtsZ
MFDLLTENNQTPRIAVFGVGGCGCNTINQLSQSPLNDNAQLIAVNTDAQSLAASQCNTRLQIGLEATKGLGAGANPQKGHEAAQESEAQIKELIALADIIFITGGMGGGTGTGAIPFIASVAAELNKPLVAVVTTPFCFEGHQRNQLANTGVEQLMQHANAVIVLPNDKLAETLDKKITLVNAFFESNRILQDVLLGLTTTISQSGLINIDLNDFIAVVSHQGRAAMGVAKQVKGEDLQLTINNALKNPLLEEVDLTHAKGAIVSVMATEDIELSQYNNIGTTLNQQLDPSALVIIGLTIVPELDCDLELMIIATGIQAPVVSSAVQVDAATLPPPKDRFASLDLLNIHDLLNEKSGDSRNDLHYQSELDIPTYTRQKQLN
>NC_014012.1|WP_013050622.1|1540309_1540498_+|AlpA-family-transcriptional-regulator
MRLIKLHEVMSSTGLARSTIYKYLEEGCFPKSVSLGARAVAWVESEVQEWILSKIEERDEQS
>NC_014012.1|WP_013050634.1|1552760_1553258_-|SsrA-binding-protein-SmpB
MAKKNAKNSKNSSASIARNKRATFDYKFEEKMEAGLSLMGWEVKSIRMGKVNLSESYVFMRDGEAFLFGCTIAPLNTASTHVVCDPMRSRKLLLKRKELDKLQGLVDRKGYSIVPISMYWQKGAWVKIEIGLGKGKKEHDKRDDTKDREWQIEKARTMKKAVRGE
>NC_014012.1|WP_013050636.1|1553557_1553989_+|ubiquinone-binding-protein
MPKISRSVLVRFSAMQMYEIVNDVESYKEFLPGCVGGKVLEFDGETMLASVDVSKAGISKTFTTRNQVIPGKSIQLSLENGPFKHLLGEWRFTELTEDACKIDFELNFEFSNSIVELAFGKVFKDLMSSMVTAFTGRAKVIYR
>NC_014012.1|WP_013050637.1|1554063_1554396_+|RnfH-family-protein
MNIEQEDFVVEVIYALPTQQKRIQIKVTPGTSCIEAVELSGMQTYFPEIDLEAVKLGIFSRAVKHDEVLVPGQRVEIYRPLIADPKDVRRRRAEKAKDEGRINKITGGKI
>NC_014012.1|WP_041420239.1|1554468_1554984_-|outer-membrane-protein-assembly-factor-BamE
MTIKKKSLTLLGAAALTLSVTGCSVFDWLIYKPDIPQGNYMETQQVEKLRIEMTKEQVEYILGRPVLRDSFANNTWYYVYHYKSGRDASVIHKELIIHFENDMLTKVVGDYDLAKDFNTPLDQSRLPDAIMLGTDAKTDNAEEPMIPEQRPDVKPLVEEKDSESQAEQKFE
>NC_014012.1|WP_013050640.1|1555463_1556285_+|hypothetical-protein
MPTPKNSICRQGSLVCVGTGLNLAGQISVLSKSYIENADVVFSLVPDGFAQRWLETLNSDVRSLQPYYAQGDEIKSRRDTYDQMVQAILNAVRDGKKVVCALYGHPGVFACVSHFAIEIAREEGYIAKMEPGISAEACLWADLGIDPGNSGHQSFEASQFMFYKHTPDPTTHLLLWQIGIAGEHTLTEFHTSSDRLQVLVEQLNQWYPLEHEIILYEAPNLPIQQARIDKLPLKNLPFARLTAITTLLIPPSRKLEVNHEILAKLGITEADLG
>NC_014012.1|WP_013050641.1|1556406_1556616_+|hypothetical-protein
MSKLNDLLENLSSDAKLKAKYLENPEQVMEEAGLNDKEKTAMRSGDEKSLTDITGDKRAFSKYIYNSKK
>NC_014012.1|WP_083779930.1|1556841_1558557_+|GGDEF-domain-containing-protein
MEGKRTQDPQFVVDSLKEIDSISETMSEEQKYRTILLQAHSLGMNDNVDKAIDLLVFNLKTFPSTKLSFYRTRMLGLLANTYSFNNEFSKSFQTLRELLPLLTDIDDIESEISGYRLAVELFGEVQMKREALNYANIIYSEFDKVLIERDKCFISFNYAESFSDVYGSSQNRWSEVETLYQNAFVFCEAANEKMVMAGATLGQAKILINRESFFQAKSLIKYALDLSSSIPYPLDMAEAYLLLAKIEVHDSRLHLGVGLLNKALDIGLTIDDSQLLSKIYKPLAELSEQLGQNDKALEYLKLYQEHYSKILGETQSKIIAFETSKLDYLEKERQIRYLNKDRELYTAKAALTELQRSNERMMNTLIFGGLIILAIFAAVMAMQKRKYKMLAQHDALTGIFNRGTAQNIAENSFIKAASKREMFSVIMFDLDFFKRINDNYGHGTGDWVLKKVADMINKASRSDDIFARFGGEEFALFLPDTDEAKANAMAEEYRRIIESIETKFSGHSFAITASFGVTSSGEDDLSLDPLLHRADIAMYHSKELGRNCVTAYRPEIELSRSGYQKSKMAFG
>NC_014012.1|WP_041420241.1|1559968_1561429_+|HDOD-domain-containing-protein
MQVKSKGVDYWTKRISDQEMPALCSTVKTLEKLAKDDVSSLGLLGKSVMHDNALTSRILRVANSATYNKSQNQVTTVSRATVVLGFDTIRNICITAKLLSSLLESKGLSEPVYQRLIKLMARAFQAAMLAKMMLRDHDEELQEEVFIASLLYHLGESAFWSTGCDEAVELDAAILQCGDIKQEKGIIREMLGTSFNKLSLGIARSWGLGDVLLKSLSNPDERTPEIRSIYLANQISELLAQENPAPEDLQLRLMQAAKMLNIEVDELKLRMVRCSKATKKLAEAYGAKVLIEHLPNPMHLKKDLLTEINEPLVRMPNMMLQLKKLRELTDCAINKSDFNKVITTTLEGLLDGVGVDRCGVLLLSPNRKRLQPRIALGEGAEQMKTEFIITLEQPQCLFCDSIEHKQAMFVDDPSSPKWRLYMDPDLKSKTSATGFMIAPLVIDQKVIGMIYADRATSERKLTLIEFDNFTHFAQLANVCLSASMGH
>NC_014012.1|WP_013050644.1|1561512_1562106_-|nuclear-transport-factor-2-family-protein
MARLENTLIQAKNDNRSISVSSANTLFKASVIALTVIASASLVTVQAYAAQVTAPQLTKDNTSKPFPKAAAVLDKLHQAATQADWDTYFSLYLPAAIFIGTDATEHWSMAEFEGYARPTKGWEYTAKSRMFVSIKTQNNDPVLMFDELLDSASYGIARGTGTLIQTESGWKIAQYHLSFPIPNEIAKEITARIKSEK
>NC_014012.1|WP_013050645.1|1562254_1563079_-|zinc-dependent-peptidase
MLAIFLVSLISLVAIGWIVSRNWRIAHSRQRITQAPFPRAWREILKRRMPYFRSLPTDLQLQLKKHIQVFLSEKEFVGCDGIIIDDEVRVTIAAQACLLLLNRTTDYYPKLKQILVYPSVFFVNNQEHRSGGVVSDRQRLLSGESWQNGKVVLSWQTAQADAANPVDGSNVVIHEFAHQLDQEDGNANGAPILDRVSDYSAWSKILSQEFETLQRSAEQDIPSLFSYYGATNPAEFFAVITEVFFERPDDFYQYHRELYQELSLFFKLDPVNWH

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Crispr_ID: NC_014012_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_6

1981068-1981153

Orphan

Consensus_repeat	Method
TAGTCGAATTTCCTACCGTCAAGTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014012_6

>merge|NC_014012|6|1981068-1981153|CRISPRCasFinder
TAGTCGAATTTCCTACCGTCAAGTTTTGGCTAAGCCAACTCCGGCGAGTCAAACTTCGGTTAGTCGAACTTCCTACCGTCAAGTTT

>NC_014012|6|6|1981068-1981153|CRISPRCasFinder
TAGTCGAATTTCCTACCGTCAAGTTT	TGGCTAAGCCAACTCCGGCGAGTCAAACTTCGGT
TAGTCGAACTTCCTACCGTCAAGTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_013051000.1\|1964576_1965227_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_041419798.1\|1991889_1992150_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_157608826.1\|1994515_1995172_-\|DUF2057-family-protein	unknown	unknown	gnl\|CDD\|378258
NC_014012.1\|WP_013050999.1\|1964157_1964487_+\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|224987
NC_014012.1\|WP_013051002.1\|1966950_1967502_+\|D-glycero-beta-D-manno-heptose-1,7-bisphosphate-7-phosphatase	unknown	unknown	gnl\|CDD\|236354
NC_014012.1\|WP_013050994.1\|1958913_1959264_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NC_014012.1\|WP_013051011.1\|1995875_1996823_+\|magnesium/cobalt-transporter-CorA	unknown	unknown	gnl\|CDD\|213369
NC_014012.1\|WP_013051014.1\|1998773_1999469_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|379309
NC_014012.1\|WP_013051010.1\|1995389_1995749_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_041419794.1\|1963574_1964027_+\|HPP-family-protein	unknown	unknown	gnl\|CDD\|377434
NC_014012.1\|WP_013051013.1\|1997360_1998620_-\|HD-GYP-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NC_014012.1\|WP_013050996.1\|1960741_1962766_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013051012.1\|1996827_1997148_-\|DUF3135-domain-containing-protein	unknown	unknown	gnl\|CDD\|378640
NC_014012.1\|WP_013051008.1\|1993397_1994447_+\|patatin-family-protein	unknown	unknown	gnl\|CDD\|132847
NC_014012.1\|WP_013050997.1\|1962919_1963474_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_014012.1\|WP_041420272.1\|1984848_1985358_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NC_014012.1\|WP_172634431.1\|1968694_1980784_+\|DUF11-domain-containing-protein	unknown	unknown	gnl\|CDD\|273634
NC_014012.1\|WP_041419795.1\|1965370_1966690_-\|aminopeptidase-P-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|182804
NC_014012.1\|WP_013050995.1\|1959745_1960117_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013051007.1\|1992749_1992944_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_041419795.1\|1965370_1966690_-\|aminopeptidase-P-N-terminal-domain-containing-protein	gnl\|CDD\|182804	PRK10879, PRK10879, proline aminopeptidase P II; Provisional.	1.41354e-119
NC_014012.1\|WP_013051013.1\|1997360_1998620_-\|HD-GYP-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	1.35288e-58
NC_014012.1\|WP_013050999.1\|1964157_1964487_+\|multidrug-efflux-SMR-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	5.40483e-26
NC_014012.1\|WP_013051002.1\|1966950_1967502_+\|D-glycero-beta-D-manno-heptose-1,7-bisphosphate-7-phosphatase	gnl\|CDD\|236354	PRK08942, PRK08942, D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase.	1.26851e-112
NC_014012.1\|WP_013050994.1\|1958913_1959264_+\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	1.31417e-32
NC_014012.1\|WP_013051011.1\|1995875_1996823_+\|magnesium/cobalt-transporter-CorA	gnl\|CDD\|213369	cd12835, EcCorA-like_1, Escherichia coli Mg2+ transporter CorA_like subgroup. A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporters Escherichia coli CorA and Salmonella typhimurium CorA (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.	5.89811e-163
NC_014012.1\|WP_013051014.1\|1998773_1999469_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|379309	pfam13640, 2OG-FeII_Oxy_3, 2OG-Fe(II) oxygenase superfamily. This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.	1.55149e-14
NC_014012.1\|WP_041419794.1\|1963574_1964027_+\|HPP-family-protein	gnl\|CDD\|377434	pfam04982, HPP, HPP family. These proteins are integral membrane proteins with four transmembrane spanning helices. The most conserved region of the alignment is a motif HPP. The function of these proteins is uncertain but they may be transporters.	1.27107e-33
NC_014012.1\|WP_157608826.1\|1994515_1995172_-\|DUF2057-family-protein	gnl\|CDD\|378258	pfam09829, DUF2057, Uncharacterized protein conserved in bacteria (DUF2057). This domain, found in various prokaryotic proteins, has no known function.	4.05905e-50
NC_014012.1\|WP_013051012.1\|1996827_1997148_-\|DUF3135-domain-containing-protein	gnl\|CDD\|378640	pfam11333, DUF3135, Protein of unknown function (DUF3135). This family of proteins with unkown function appears to be restricted to Proteobacteria.	3.61683e-32
NC_014012.1\|WP_013050997.1\|1962919_1963474_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.85992e-13
NC_014012.1\|WP_041420272.1\|1984848_1985358_+\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	3.87337e-23
NC_014012.1\|WP_172634431.1\|1968694_1980784_+\|DUF11-domain-containing-protein	gnl\|CDD\|273634	TIGR01451, unnamed_protein_product, conserved repeat domain. This model represents the conserved region of about 53 amino acids shared between regions, usually repeated, of proteins from a small number of phylogenetically distant prokaryotes. Examples include a 132-residue region found repeated in three of the five longest proteins of Bacillus anthracis, a 131-residue repeat in a cell wall-anchored protein of Enterococcus faecalis, and a 120-residue repeat in Methanobacterium thermoautotrophicum. A similar region is found in some Chlamydial outer membrane proteins.	0.00170887
NC_014012.1\|WP_013051008.1\|1993397_1994447_+\|patatin-family-protein	gnl\|CDD\|132847	cd07208, Pat_hypo_Ecoli_yjju_like, Hypothetical patatin similar to yjju protein of Escherichia coli. Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	3.51027e-79

>NC_014012.1|WP_172634431.1|1968694_1980784_+|DUF11-domain-containing-protein
MKYDLVVTNNGGKLVKGLSVTAGLLDIKTSDINGNPVDAFTSVSVDATATVGSQAGEFNSHGDLNAKQVTLAEGGVVTYHIKAKVSPTAAQEIEVTAQLTSSFLSLESNSVTTPRAPYELDVIKSADNLLYSPGGKVSFTIKVSNTGQWKIRHALVEDNLSGITAEDMEGNTIPAFSSIDNITATTQGKGSSGGVFDAHGPDLQAKDVVVAKGGWVEYRITATVADTLIGDILNYAEATAHDDSTLSNPVVIEPEEANVVITKQVSPTADYQVGDTLTYTIKLENTGLGIANHYQVEDKINDIVVDLANNDLAEYNHINVTASPFETWQIEVKDLGSHSLSEFMASGGTSSNNDLNDLISLYPNESVTYIITATSKAVAISDITNTASVNSDSTVEKTASATVTALATIKDFTAHKSPNGTEYMPGDWVSYTIEVSNTNATQFADNISLTDKIATCNTTELVDGSTGSPFEKWKLSVKSVDVEGSDPGSFAFGVEKTGDIDLVLDLAPKGKVVYQLDVLVNPDAIGTIIDNPSCDDTVPEDGSGINMPDGKVEVKKLVDQREFAPGDDLTYTITIKNSGKGYLHNVPVVDAISAITADGVTGSAFTSWTITTSVTDSSGAPSSHSNPDLDGSIAADNDLDTHANVFPGDTITYTIVATTKNTITSIVRNKVMVDGSAYSDVGAEPYKYDLSVEKTVDKIRYTQGDDTLRYTIVISNADIAGYAKDIPVFDDIAGIQAELLHQKGEMAPAFESWTITAALDGRPNQDSGLPGNVSSNVNLDTKFSLAAGGTLTYTIEAKIPERTQDHIVWGHIVNNVVVDKTETASAESYYRLPNLVVDKQVSETNYTPGDTVSYTITVKNIGAGYANNTDVKDDIAALGLFNHWTVKDESFGIGSRIVGGKVADDKNIDTKVDIAPGGRIVFVITGVVVNNIHGQVTNTVKVHEPLDNRDSESSADIFPITDPELPSVDIHKESSPLHYRPGGVQTYTITVRNDSDVLVENLRVFDGMSAIESTLANDKDNHFADIVGSPFESWTIESTSKTLAKNSTSADLDEVITLAPNSSKVYTIKAIIKDNVVDETVTNRVCLFRENGDDAGCAEAENHREMSGGEVVREVFPAKYKPGDTITYKITASSKLGYYNNIHILDELENLSVDLIDKDGKHTQGHPFNDKFNVDVTKTTLNGDGTTDGTLDGQVENNKNLDTTIDVGPGDKVVYTITGVVRDDAAGDIINGELVVKPFKPNWDYSKESDNKNYQPGQTLTYRLSIKNTGKGHAVGIKVQDLLSEVMVDDIKGRSVKAYESWSFTKVKQKPIATNSATGAKPEFELYYNAGSYSDNNDLDTEINLPIGGEIVYTVVAKVIDRAEGEITNVLKVNNDTTSVSHSQSTENYKLTKQVIGYFDASHNKLSGEGYTPGGYVAYKIRVENSGKGSIQQLKVVDDLEGVTAAWFDGNTGPVFESWTIKAKTDGGMVSNYGVFTANNNIDTLVDIGTGGYVEYYISAKINQEVVGDFHNSVTAGRTTKNSEISVMQQAQFSLSKIAYSDALFTSRKSDYAPEDKVFYQIKLENKGWGTVYAVHIRDMLKNIKSEIAEDTLPAGSWVTAEPFTEWKVTAHYTPGRVTNIGGFSDGDNINIDTDFDLAPNEAIEFSVEAKLDYVVLGEVRNHVEAASEKKNATLKAQVKDISHSKVITSIGGKPYQANSHYRPGDEVVYTIKITNNHNAWANNVAIKDKIGDIKTLLAGGSRGQAFSSWRVEYEVASGSDSRTDTQVPVNSADSDIDFITDIGPLDEITIRITAVIKDTATGDVDSNHLLVDGNTDATQVIPPFAPKLTYGKEVIKTSADGNDKTEYAPKGEVKYRVWVSNSGEGFAHDLLITDPIDKIVSADGQKAFTAWSVEQDPKFAPVLSVVTGDISGNVPLNAHGDIAPGETLSFFVTGKVAGDVTGLVRNTLFVNDADVAHVDLNSGVMSITSSKHTDTPNYTPGSEVRFQIEITNTSDSIAIVPVEDDLNAIMVMTADGTMQPALTDIVISARVVGDKVNSQIPASLGTPGKLNTEIRIAARDSSATPVNTSIIFDISAKVNDSAVGEFTNTASIDDKDFGLIEGNIKPLPAKISLDEHAIKVPAVYAPGESIGFEVVIKNIGSGYALNTELANLLDKTTAFAAGSTDKVRVFDKWDKVTVTSSSSLTTIIAGKELNNSEGYFNEFNIHPGDSVTLQLFGTVKPEILGDIDNMTQVTQGNNILMDDAIYTPVEGELLILKTADSPTYLPGNRVGYNIKLENRGDGWLNDVKISDLLSDIETELAGGITDKAFVPSSMVLDSVVSTPLVPGDLGDIKVVDNQLIGTADIAPHQVINIRFSAEVKDTALGEIVNIAKANELSSEIAINPPVATVKLSKTVGKPTYMPGELITYTVTVANTSQTWANDVELVDDLAGIMTEQAGGAMVNAFVPGTLTATNTSTVELVKMQVKDNRLSATMDIAPMSEVSFTLEAKLQDTILGEVTNIANLGDQDASAVITPQDTPKVQITKLANNPIYLPGGLVTYTVTVKNNADTWANDVQVSDDLGKITTEHASGVTFDAFVKDSLSVTSDSKPNLIEMTILDNKLTAQVDIAPKSEVNFTIRAKLNNTVLGEIVNTAIADGNEAEAKINPAPSEVEIKKTVSHVRYIPGGMVTYQVTVSNTTEAWANDVSIVDDMSAITTQLAGGIPGSSGLAFVANSMVANHDTRPELVTMSVANNKLQASADIAPMTDLVFTIKALLVDTALGPVINQASADGKTSDVMITPVANPILSLTKTVSKPTYLVDEDVVYTVTLINAGDAWAHDVQLEDDLNAITTELAGGEMGTPFVDASLVVSHTSKPELIVLGTEPNKLSARLDIAPHSQVVFTLTAKMKSSALGEVVNTVTADEETAGVSILPEDADLIFTKSVDKENYLPGDLLTYTLVIENRGLGWANDVLIQDAIAGINTDLAGGLNGQAFVPGSLEVTHDSTDELVQMALDGGVLVAHADIAANSSLTFVIKAQLKDTALGEVLNKASANDLNDEALSIPSKATVTLVKTVDSPVYQDGGKVTYHLTLTNQTDAFAHQVNLKDMIKEIKVLTIDGVEERAFKSWEYSYQSGDSNTSVVSQSRKRSDSANNTNIEVMIDLAPKDTLVFTVDAVVRDDAVGEISNTADIKFDGAHQESNVVINPDVAVLESEKVSVETEYVPGETLNFTLTMKNTSNNYIFDTLVSDDMSAIQVEYADSTLGAAFVPGSLSFTPSEIGKGSSAKPTSNSEYEVDIAPGSEIIFNVSGIVNENAVGDIQNIAQVDGEEVESNLVPTAVANVVGELFTRAQYYVPGEPVEYHLVLKNEGQGVAKDVYLLTQFAKSTGTWINQEQGLAFDSWTISAATSGNNTTSGEFTDNEDIATKLNIAPGGSVDFTITTTVDLDMLTNIDVYGFFLGSTYHKSLKVNQSIDGIGGADKLSYLDLPPVGAKMQVEKTVEKTNYIDSDTQVIYHLSAVNIGEGNAPLVNLFDDIAGLNSPKGIDVFTDWSIEGTEYEGSSVVDQFTLKGDQLNKHNLNIQRNFKSKGRSRIELVISATIAKHLDDDVTNTFVVTEQNGTVTQDDATTHIKKIPDNQGELKITKQASKNTAQVGEVIEYEIIIDNDNESYFKDVAVFDKLPAGFRYQLDTTEMTLSGIDGKFDTQDDVVLTKQPTLSGQLRFANVDFEPFEKLRIRYLLKVSVGVTFGKYINTAQAKIKGVNVSDIATATVEIQGDKLFDTASIIGKVFEDINGDGYQADAGAFDIKVMADLPRDAYVADSTKLKLTDKFEPVDDLDDASAKILAPIQSGIEIDKLMGQSRNRTLDESHLAVIRFQTRTPDSFPLTLTTGEGTRIEFSSEGQVTRSLNGDVKTGLSAEVINVTRNLYRIKAVEPRYLWEIVIDNIGVYEDGIPGARLITTEGIKIETDEFGRYHVPDQWVTDKKGRNFLVKLDSDSLPTGMKVISENPKVKRISPYGLAKFNFSVQAASVKTTDNSASKASATKSQDTE
>NC_014012.1|WP_013051002.1|1966950_1967502_+|D-glycero-beta-D-manno-heptose-1,7-bisphosphate-7-phosphatase
MSPAVFLDRDGVINIDHGYVHQVDDFEYVEGVFDACRSLKEMGYKLAVVTNQSGIARGMYSEDQFHSLTEWMDWNFADKGVELDGIYYCPHHAEKGLGDYKQDCDCRKPKPGMMLTAAEFLSIDLSQSVMVGDKRDDMLAAKAAGIPTRILVRTGKSVTDEAIAAATIVLDSIADVPAYLKSC
>NC_014012.1|WP_041419795.1|1965370_1966690_-|aminopeptidase-P-N-terminal-domain-containing-protein
MSCDLYQTRRKALYDQLPEGSFVILAGYSQKVRSKNIKYHFRQDNDFLYLTGFAEPDAVALLCSDKTKDSGFNYSLFCRPKDKAQEVSFGERAGIHGAITDFNADEAYDIAELEAVLLSQLASHQHIFICDELGRFSSRVMDWMNHQRNTASFDTIKQHLSVTPLAKVLHPMRVIKSPDEIAKIKAAVKASTDAHMTVMKACKPGINEAELAATFNFTIAKYGATDVAYPNIVASGNNACCLHYEENCCTVEDGQILLIDAGAELAHYASDITRSYPVNGTFTREQKAIYSLVLTALDSAIAQVKPGASWNRLHETCMEVMAKGLLELGLLSGNIDDIMKNETYKRFTVHKTGHWLGMDVHDVGPYHDEQAQWRKLEPGMTFTIEPGIYIPLSATDVPEGYRGMGIRIEDDILVTQTGHENLSVKVPRTIAEIENIMAK
>NC_014012.1|WP_013051000.1|1964576_1965227_+|hypothetical-protein
MELIKYLNDNFFTKKELLDVSKVTELELLSYQNDRLMPKCSYKLTLNVKSDSFFGVHNDEQEIEYYAKGYASWLAIVQSLKSPESIYAIFYNRYKIAIENLKEQGHYSISYKLKSGLDEHIKEEWNNFLNGIYGLCTQTGLPEDIAAKEFSILEINEISEFNELTSQQMNKLTLAVNLLDSVSSLFAPHERLKSSRHRLVNEIRRKYKLPNNQITK
>NC_014012.1|WP_013050999.1|1964157_1964487_+|multidrug-efflux-SMR-transporter
MGYWYLAIAIGAEVIATLALKASDGFSHSTSSTVCVIGYAVAFYFLSLVLKTVPVGIAYAIWAGMGIVLIASISAVIYKQIPDAPAIIGMVLILAGVLVINVFSKTVSH
>NC_014012.1|WP_041419794.1|1963574_1964027_+|HPP-family-protein
MNKLIPHLIAGLGASIAIGLLSFLDTNLTNVVLIMAPFGATAVLVFGLPDSPLAQPKNVVFGHLITAFIGLFFVHFIEVSPLTLGLATGIGVSAMLMSKTTHPPAGANPLLIMLSGQSLGWFFLVTPVLIGALVIVLIGKFMQELQKKFN
>NC_014012.1|WP_013050997.1|1962919_1963474_-|TetR/AcrR-family-transcriptional-regulator
MSKKRQLLIDTALDLFYMYGINSIGINEILKVSGVAKKTLYSHFESKDALILAALEQRHLIFIDWLEDKLQRANTDEDLVSRLFIALEAWIANTDPKLGSFRGCFFINTSAEFSEPSSDISLYCRDHKRQVHQVITKFMPNSDPLFIDAVCIMQEGVITAAYVANDHTAAKKSIEILKKLRQSF
>NC_014012.1|WP_013050996.1|1960741_1962766_+|hypothetical-protein
MYNKMILCSLLSFILFGCGGGSGGEKKPTILPFAYNVTIDGNTRIGELVRGQYEFEANDKSESDASTTYWLKGDGTKISDGDRLLLDDTSLEGGEVKFCVLPINAGNRLKGDLVCSQSAYVDSRVIIHIPTVSFLFVSEASRVGHELTVLVDGSIQELTYHWYKDDVQIPDIRVGTLALTKKYEGLRIHVCTTYDSSSNDKSCSEKTAPIRAAMGSAPTVDSLSLNFGADEIKVGETITVEAVYIDIDDDKEDSVRRQYRWYSKESIVGNAKSLLVSPQVVNQSIKACVTVYAKTGSPKASEQTCSKDVYVIEKDPVAPIVSGVSIRGINIEGYRLKGEYRYFDGNNDTEGKSLLEWKLDADHSPALTEGDTIRLSASIVEQASLINKATPSIYFCVTPYDELGTKGKTACEAQRLATISFKGSLTPGGELAIENFYYPEFTQSWWQAKGSEFQYSMSFKSNFFNSWKGSVFYDSIVFTRYRPVQFCVKATDIDGDEQDICKEVTYDEKYENVSGAPLGGNKVAFEPMKEYNVDVDGNKYRLYRPILASEFTIISGGEFLSAESVIYDTFLGKETDAARGIKLTPNEAIKYCQRTSGGVVPNKVLKAAFFSNSEDSIIRNWSSFESAEWLVISERGKPVEYGTWAADAFEETPIEADPNKTYRFICHHKLGAQL
>NC_014012.1|WP_013050995.1|1959745_1960117_+|hypothetical-protein
MIIVKYLFAAVISSVLFFAIFFWLYLSGTNTRYCPLSHILDDLSVCFILDSVDDRVLIQHGELDTNDFYLEIIESGESSKFQFPSSVVNVGRSGYSAQLIANDRAAILINDEIFVLKKYTGSY
>NC_014012.1|WP_013050994.1|1958913_1959264_+|VOC-family-protein
MTKNNQINYIEIPAKNIEATKTFFSDVFGWSFVDYGPDYSSFAAQGVDGGFFKSDLVVSTKNGSPLIVLYSNLLETTQDNIEKAGGKIVKPIFSFPGGRRFHFSDPNGNEFAVWSE
>NC_014012.1|WP_041420272.1|1984848_1985358_+|OmpA-family-protein
MQKTALVLITGLSLVACSTQTYVSEENLDKFAGINVEKFLIAEIVTEIKQILPPNKKVFISLISHFDFDSSLLKDEDKMELDKLIALVNSLDGKLVIKGHTDYQGSNAYNENLSMRRARTIQDYLEGQLTQGEYEYSVEHFGELQPIIESHTLQANALNRRAMVIFTEK
>NC_014012.1|WP_041419798.1|1991889_1992150_-|hypothetical-protein
MKLGTPLSGGATAMDGGSVEIAGANIYLSHGMNLTAFGLLHSPCEKVISKAVKRKNPQHKVLGIYRLSLREIRRLEMTYSHMGAKK
>NC_014012.1|WP_013051007.1|1992749_1992944_-|hypothetical-protein
MNTQYSAIIERGETWFRSGGASHRDVVNVRNAWMQLLTKLSGGATAMDGGSVDIEGAFIDRHRG
>NC_014012.1|WP_013051008.1|1993397_1994447_+|patatin-family-protein
MPLSIASNSNFKPFIDPVLADDPSLNEGIVQRYNTPEPIAHTALIAEGGGQRGIFTAGVLDSWLESGYNPFELLIGTSAGAQNLSSYLTGQVGFAQASIAHLSKQSQFFNIKRGLKGANTVDLDWYFDQVSDAQFRLNTEYGLTKLESRNLLISTTNSSSYRAEFSTPNATNWLTLLKASSALPYLYRKGVKIEGDYHVDGGLSAPLPVEEAYKRGARKIVVIRTMPKEYTAHTPWVNRLKSWICSSNRCPKALDYFVHHEAAYKHSLQFIASPPDDVEVVQIFPESRLTSHILGSADAQLEHDYLMGKRAGLGFIEDNPALDLSPAHSLHFQDSLARSNTRVKRVHYC
>NC_014012.1|WP_157608826.1|1994515_1995172_-|DUF2057-family-protein
MLTAACSLPAYANISLTLPKSAQLLVVNGVVMEDKTSLDLNDGNNQIVFKYNTSFWQQGQQRRFASEAVVLTFSGTNQEYSLSLPKLRSSAQADRFNKQPQIILEDDNGKSVDHNSHVLLKVGLQLGRDYAQEVASYNQTGAIAALTALVPTADITSLPAPQTTSVATAAILNSASANTTNNIKIHKDQINVGQMLDFWYSQADEETRKAFKDRIKQN
>NC_014012.1|WP_013051010.1|1995389_1995749_+|hypothetical-protein
MLTKILITALVIVGAFFYLRKPARLPAQTEIEAEGKSIMLRYIFMGLIAVSMLGSTGYWYWNWQDGNQVVTVTIVSPIKDSTSVYHVRKKDIFNNKLTTVEGIHIRLSDQDRVIIANSM
>NC_014012.1|WP_013051011.1|1995875_1996823_+|magnesium/cobalt-transporter-CorA
MITAYVYKNRELAITELNIQDVVPPDTLWLDLFKPSDQEREWLSKYSVEEVPEEEDINEIEASARFYQNNDGLHINSLFPLRVGQDVKGVNVSFNLRKDFLLTIREDDVGLIRLLRNYLRLGRIKVTTPQGLFLELFNLKVDYLSDLIEDIYSVVDGVSEQVFENNELDEVFKLITLQEDSNGKIRLSLLDTQRSLRYMQRYYRGELTDDNLKDLREMLLDIESLMPHSQFIFDKLNFLLDAAMGFSGLQQNKIIKIFSVAAVIFLPPTVIASAYGMNFTNMPELAWQFGYPMAILMMLASAGGTYAFFKRKGWL
>NC_014012.1|WP_013051012.1|1996827_1997148_-|DUF3135-domain-containing-protein
MTELPDFDKLRWLAENEPDELEELQQTLCKEAIDSCPESNKEQLISMQFHLKQQLSLCSNPYHRCYLAIKIMNDKFIALNTIMNSPEEFRQQNAKILILPAKKAID
>NC_014012.1|WP_013051013.1|1997360_1998620_-|HD-GYP-domain-containing-protein
MNKSRKVAVNQLQVGNFIRLPISWKDHPFLFSSFRLKQQAQIELIKKLAIEFVYVDLERSDIPPLTEEVARTKVQTPQKEDLDSLTIEMQKTKTERIEKLKQMRRDLQKTEQDFDRSIAKMRNLVAKLRNRPLNAIDDAKELINEMSEKLLNSDNLVLHLMGEAKDDESIYYHSLNVAVLSMLMAKELGWDKTDIELVGMGSLFHDTGKLKIPTQLVRKKTPLTPPEVNFMKQHPVMGADLLKLAENFPSGAMPIVLNHHEYLDGSGYPRGLKENNIDKLCQLVAVVNLYDSLCHPDTQMKARTPYAALGHIYKNFKTQLNQEVTGKMIKMLGIYPPGSIVELSSGQFAMVMSVNLDKILFPRILVYDAMVPKDQAPIVDLEVEGLSIVRCIQPMALPEKIFKYLNPRERVSYYIGSDK
>NC_014012.1|WP_013051014.1|1998773_1999469_+|2OG-Fe(II)-oxygenase
MDFIEVYPNAIPDDLCDRLMACFEQHKGVTDGRTGQGVDLEKKISRDLTLDSFEDLQGIRNELLTYTLKFSTKYFNQYSLALMGAVSVQVSDDKGQGVALTPDNYQSLGEPRSEALVKYLYRSGTINVQKYQKGLGGYPHWHSEQFPQEGYNEALHRVVLYMFYLNDVEEGGETEFFYQNRKLKPKKGTMVIAPAGFTHSHRGNKPISGDKYIATSWVMFNRAEQLYAPIG

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Crispr_ID: NC_014012_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_7

2056962-2057091

Orphan

Consensus_repeat	Method
TATAAGCAATACCAGAAAGGGCCGTTAGCTCAGTT	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NC_014012_7

>merge|NC_014012|7|2056962-2057091|CRISPRCasFinder
TATAAGCAATACCAGAAAGGGCCGTTAGCTCAGTTTCTTGTAGAAACAGACAGTTGGCTTTTAACTAATGATAGTTAGTTATTTATTTCGATATATATAAGCAATACCAGAAAGGGCCGTTAGCTCAGTT

>NC_014012|7|7|2056962-2057091|CRISPRCasFinder
TATAAGCAATACCAGAAAGGGCCGTTAGCTCAGTT	TCTTGTAGAAACAGACAGTTGGCTTTTAACTAATGATAGTTAGTTATTTATTTCGATATA
TATAAGCAATACCAGAAAGGGCCGTTAGCTCAGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_013051072.1\|2059658_2060801_+\|porin	unknown	unknown	gnl\|CDD\|308243
NC_014012.1\|WP_013051062.1\|2047564_2048434_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|375819
NC_014012.1\|WP_013051076.1\|2064016_2065969_-\|acetate--CoA-ligase	unknown	unknown	gnl\|CDD\|234677
NC_014012.1\|WP_013051083.1\|2072313_2075703_+\|chitinase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|225862
NC_014012.1\|WP_013051082.1\|2071443_2071872_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|239526
NC_014012.1\|WP_041419809.1\|2055784_2056510_+\|tol-pal-system-protein-YbgF	unknown	unknown	gnl\|CDD\|182745
NC_014012.1\|WP_013051084.1\|2075887_2078845_+\|chitinase	unknown	unknown	gnl\|CDD\|119365
NC_014012.1\|WP_013051065.1\|2051768_2052458_+\|protein-TolQ	unknown	unknown	gnl\|CDD\|131843
NC_014012.1\|WP_013051068.1\|2053865_2055194_+\|Tol-Pal-system-protein-TolB	unknown	unknown	gnl\|CDD\|235312
NC_014012.1\|WP_041420280.1\|2062111_2063860_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223989
NC_014012.1\|WP_013051064.1\|2051380_2051779_+\|tol-pal-system-associated-acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|274304
NC_014012.1\|WP_013051069.1\|2055228_2055765_+\|peptidoglycan-associated-lipoprotein-Pal	unknown	unknown	gnl\|CDD\|182744
NC_014012.1\|WP_013051074.1\|2061502_2061991_+\|membrane-lipoprotein-lipid-attachment-site-containing-protein	unknown	unknown	gnl\|CDD\|369706
NC_014012.1\|WP_013051061.1\|2046750_2047422_-\|ribonuclease-T	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|179951
NC_014012.1\|WP_013051073.1\|2060889_2061159_-\|glutaredoxin,-GrxA-family	unknown	unknown	gnl\|CDD\|183036
NC_014012.1\|WP_041419808.1\|2049061_2051212_+\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224422
NC_014012.1\|WP_013051081.1\|2070561_2071221_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_014012.1\|WP_013051066.1\|2052457_2052892_+\|protein-TolR	unknown	unknown	gnl\|CDD\|274306
NC_014012.1\|WP_013051079.1\|2069665_2070277_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NC_014012.1\|WP_013051067.1\|2052895_2053855_+\|cell-envelope-integrity-protein-TolA	unknown	unknown	gnl\|CDD\|274303

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_013051072.1\|2059658_2060801_+\|porin	gnl\|CDD\|308243	pfam02530, Porin_2, Porin subfamily. This family consists of porins from the alpha subdivision of Proteobacteria the members of this family are related to pfam00267. The porins form large aqueous channels in the cell membrane allowing the selective entry of hydrophilic compounds this so called 'molecular sieve' is found in the cell walls of gram negative bacteria.	0.00619839
NC_014012.1\|WP_013051062.1\|2047564_2048434_+\|OmpA-family-protein	gnl\|CDD\|375819	pfam18393, MotY_N, MotY N-terminal domain. The bacterial flagellar motor is a rotary motor complex composed of various proteins. MotX and MotY are essential for the Na+-driven flagellar motor motility of Vibrio, Shewanella and Aeromonas species. MotY is main component for T-ring formation and absence of MotY completely disrupt the T-ring formation. This is the N-terminal domain of MotY which is shown to be essential for motility and responsible for the interaction with both MotX and the basal body. Functional analysis suggests that MotY-N connects the basal body to MotX and that the PomA/PomB complex associates with MotX to form the functional stator complex around the rotor. MotY-N alone does not associate strongly with the basal body, but the partial T-ring structure made of the MotY-N/MotX complex is sufficient to allow at least a few PomA/PomB stator complexes to be incorporated into the motor.	2.66003e-74
NC_014012.1\|WP_013051076.1\|2064016_2065969_-\|acetate--CoA-ligase	gnl\|CDD\|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NC_014012.1\|WP_013051083.1\|2072313_2075703_+\|chitinase-C-terminal-domain-containing-protein	gnl\|CDD\|225862	COG3325, ChiA, Chitinase [Carbohydrate transport and metabolism].	1.99589e-131
NC_014012.1\|WP_013051082.1\|2071443_2071872_-\|acyl-CoA-thioesterase	gnl\|CDD\|239526	cd03442, BFIT_BACH, Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, and brown adipose tissues. The archeal and eukaryotic members of this family have two tandem copies of the conserved hot dog fold, while most bacterial members have only one copy.	2.10966e-43
NC_014012.1\|WP_041419809.1\|2055784_2056510_+\|tol-pal-system-protein-YbgF	gnl\|CDD\|182745	PRK10803, PRK10803, tol-pal system protein YbgF; Provisional.	1.35817e-53
NC_014012.1\|WP_013051084.1\|2075887_2078845_+\|chitinase	gnl\|CDD\|119365	cd06548, GH18_chitinase, The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.	3.87046e-72
NC_014012.1\|WP_013051065.1\|2051768_2052458_+\|protein-TolQ	gnl\|CDD\|131843	TIGR02796, Protein_TolQ, TolQ protein. TolQ is one of the essential components of the Tol-Pal system. Together with TolR, it harnesses protonmotive force to energize TolA, which spans the periplasm to reach the complex of TolB and Pal at the outer member. The tol-pal system proves to be important for maintaining outer membrane integrity. Gene pairs similar to the TolQ and TolR gene pair often number several per genome, but this model describes specificially TolQ per se, as found in tol-pal operons. A close homolog, excluded from this model, is ExbB of the ExbB/ExbD/TonB protein complex, which powers transport of siderophores and vitamin B12 across the bacterial outer membrane. The Tol-Pal system is exploited by colicin and filamentous phage DNA to enter the cell. It is also implicated in pathogenesis in several bacterial species [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	3.07431e-112
NC_014012.1\|WP_013051068.1\|2053865_2055194_+\|Tol-Pal-system-protein-TolB	gnl\|CDD\|235312	PRK04792, tolB, Tol-Pal system protein TolB.	0
NC_014012.1\|WP_041420280.1\|2062111_2063860_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	9.42433e-83
NC_014012.1\|WP_013051064.1\|2051380_2051779_+\|tol-pal-system-associated-acyl-CoA-thioesterase	gnl\|CDD\|274304	TIGR02799, Acyl-CoA_thioesterase_YbgC, tol-pal system-associated acyl-CoA thioesterase. The tol-pal system consists of five critical genes. Inner membrane proteins TolQ and TolR convert protomotive force to energy that is transduced through TolA to an outer membrane complex of TolB and Pal. The system is known to be required to maintain outer membrane integrity. In a system with several homologous parts, ExbB and ExbD transduces energy through TonB to a variety of outer membrane proteins, many of which are siderophore receptors. The tol-pal system therefore may also be involved in transport. This family consists of a protein nearly always found in operons with the genes of the tol-pal system. The significance of this thioesterase to the tol-pal system is unclear, but either of two observations may be relevant. First, Pal, or peptidoglycan-associated lipoprotein, has a conserved N-terminal cleavage and acylation that makes it a lipoprotein. Second, the tol-pal system is implicated not only in the import of certain organics but also in the maintenance of outer membrane integrity (by an unknown mechanism).	3.31311e-61
NC_014012.1\|WP_013051069.1\|2055228_2055765_+\|peptidoglycan-associated-lipoprotein-Pal	gnl\|CDD\|182744	PRK10802, PRK10802, peptidoglycan-associated lipoprotein Pal.	1.61028e-66
NC_014012.1\|WP_013051074.1\|2061502_2061991_+\|membrane-lipoprotein-lipid-attachment-site-containing-protein	gnl\|CDD\|369706	pfam08139, LPAM_1, Prokaryotic membrane lipoprotein lipid attachment site. In prokaryotes, membrane lipoproteins are synthesized with a precursor signal peptide, which is cleaved by a specific lipoprotein signal peptidase (signal peptidase II). The peptidase recognizes a conserved sequence and cuts upstream of a cysteine residue to which a glyceride-fatty acid lipid is attached.	0.00109626
NC_014012.1\|WP_013051061.1\|2046750_2047422_-\|ribonuclease-T	gnl\|CDD\|179951	PRK05168, PRK05168, ribonuclease T; Provisional.	1.03202e-157
NC_014012.1\|WP_013051073.1\|2060889_2061159_-\|glutaredoxin,-GrxA-family	gnl\|CDD\|183036	PRK11200, grxA, glutaredoxin 1; Provisional.	1.30646e-58
NC_014012.1\|WP_041419808.1\|2049061_2051212_+\|S9-family-peptidase	gnl\|CDD\|224422	COG1505, COG1505, Serine proteases of the peptidase family S9A [Amino acid transport and metabolism].	0
NC_014012.1\|WP_013051081.1\|2070561_2071221_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.45974e-59
NC_014012.1\|WP_013051066.1\|2052457_2052892_+\|protein-TolR	gnl\|CDD\|274306	TIGR02801, Protein_TolR, TolR protein. The model describes the inner membrane protein TolR, part of the TolR/TolQ complex that transduces energy from the proton-motive force, through TolA, to an outer membrane complex made up of TolB and Pal (peptidoglycan-associated lipoprotein). The complex is required to maintain outer membrane integrity, and defects may cause a defect in the import of some organic compounds in addition to the resulting morphologic. While several gene pairs homologous to talR and tolQ may be found in a single genome, but the scope of this model is set to favor finding only bone fide TolR, supported by operon structure as well as by score. [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	1.01908e-52
NC_014012.1\|WP_013051079.1\|2069665_2070277_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	2.0635e-48
NC_014012.1\|WP_013051067.1\|2052895_2053855_+\|cell-envelope-integrity-protein-TolA	gnl\|CDD\|274303	TIGR02794, Protein_TolA, TolA protein. TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	1.85157e-30

>NC_014012.1|WP_041419809.1|2055784_2056510_+|tol-pal-system-protein-YbgF
MKRAVLTTAILLSIGVASAALAPVANAAGSSTEERVARLERILQAKQESEFQTQQRLDTLQQEVLDLRGLNEQHGYQIDQMLKRQRKLYEEIANLSAKPTASTATTPKVSSTSSSLTLGETASYEYAVNLVLKQRKYDEAIPAFRGFIKKYPDSTYAANANYWLGQLLYNKSEFESAKKAFDTVVNRFKDSNKRADSLVKLGMIAEKVGTVSAAKVYYQQVIKEYANSAASRLAQQQLSAL
>NC_014012.1|WP_013051069.1|2055228_2055765_+|peptidoglycan-associated-lipoprotein-Pal
MDLNKLFKAMLVALPIIALSACSSTSESETDATGSTTGSGSELVTGGVETGAVTPILTPEEQQRLKYQELRKEHIIYFDFDRSSVSAHFAEILRAHGHYLVEHPNVRLMIEGHADERGTPEYNIALGERRAKAVAKYLQGMGVLPSQMSIVSYGEEKPLDFSRTDDGFAINRRAVLVY
>NC_014012.1|WP_013051068.1|2053865_2055194_+|Tol-Pal-system-protein-TolB
MKTLGKWLFLSLIILSSPVRAALDIVITEGVDAARPIAVIPFVWQGMGVMPEQISDVVMSDLTRSGTFKPLDDLGLPQRNISNVSQFVAKDWSSIEAEAVIMGSVKPRGNDQYLVTFDLVDLAKAQMQQGAGPRSSREYLIDSRETVITAAQFRHYGHRISDLVYEKLTGIRGAFLTHIAYVMVKHGEKSPYQLMISDYDGHNEQMLLRSAEPLMSPSWSPDGSKLAYVSFENKKSEIFIQDIYTQSRHKVTSFKGINGAPVFSPDGKKLALTLSKDGQPEIYVIDIATKALKRVTNHYAIDTEASWFPDGKSLIFTSERGGRPQIYKATLASGKVQRLTYEGEWNLGGSVAPDGRSMIFVNRTNGKFNIARMDLETHFMQVLSSTRLDESPSVAPNGTMVIYGTTHDGKQVLGAVSTDGRFKARLPAGQGEVKSPSWSPFL
>NC_014012.1|WP_013051067.1|2052895_2053855_+|cell-envelope-integrity-protein-TolA
MAAKSDFTLPFVISAGIHIGVLVIIALGVDFSDKPKPQPQVSAPAMKAVMVDQRLVAQHVEKLKAEKRELARKEKARQDELERQVTQARQKRESEQAQIKKLEIERKLKEIETKNAVAAAKAAQLKQKQEKEKAQQAEKVRKQKEKEREASEKAAKKAEVKRKQEEAAAKKAADDRKRKADAERKRKEEAERKRKAEERERQLQEQMMQDALAEEHTALSQTRNKQVMSEVQRYTSMIRATIQRQLVVNESMRGKSCRIFIRLANDGFVTGTKILSGDSVVCRATKVAINKAGRLPVSSEPDVYDKLKEINLTVQPEFN
>NC_014012.1|WP_013051066.1|2052457_2052892_+|protein-TolR
MQQGYQRKRRRPVAEINVVPYIDVMLVLLIIFMVTAPIVTQGVKVDLPQAASEMLPADSKPPIVASIDADGDYFLDVGSSSSKEPLDLQEVAIRVGAIIQLEPERPVVVKADRSITYDKVIQLMVSLQGAGVPSVGLMTDSPGD
>NC_014012.1|WP_013051065.1|2051768_2052458_+|protein-TolQ
MEADISIIGLFLQASLLVKFVMLTLLSLSVMSWAVIFQRHRLLNTAKKNALKFEDQFWSGVDLNKLYKELSARQDSNTGLEILFHTGFKEYTRLSKLNSKVPGAVMDGSYRAMRVSLSREMEKLETHLPLLATIGSTSPYIGLFGTVWGIMNSFIALGAVQNATLAMVAPGIAEALIATAMGLFAAIPAVIAYNRFTTQVDSVEMSYANFMEEFSSILHRQAYSDKDES
>NC_014012.1|WP_013051064.1|2051380_2051779_+|tol-pal-system-associated-acyl-CoA-thioesterase
MFRWPISVYYEDTDAGGVVYHSKYLNFFERARTEWLKSMGVKQASLLAEDIAFVVKRAELNFCRPARFEQDLIVETVVIDLKKASLMFEQKLIDEEGVIYCEAKVLVACISLSRMRPRAIPQNIVQEFKGGS
>NC_014012.1|WP_041419808.1|2049061_2051212_+|S9-family-peptidase
MIFKSKLRKQHLLIASLALGIMGCQSAQQDSEQKTSSAPMAGDTIETIHGVQVADPYRFLEQDTEQTQAWVKRQQAEGKAYLSGIENKQAVVDRITQLWNYQKISAPFEHGEYTFFYKNDGLQAQSVLYVKTANGDEKVVLDPNTLSIDGTVALSGVSFSGDGKTLAYGVSKSGSDWQQWQFVDVATGVKLDDELKWIKFSNAVWNKDNTGVYYARYDAPTGGNLLADVNFNQKVYFHQIGSEQLSDKLVYERPQNKDWGFGIEVSEAGDYLLFSISQGTDTRNRFFYQSLEKPGEVVELITDLEAEYSFLGNDKSVFYFKTDLDAPNGKVIAIDINHSDKANWKTLIAESSDPISSIAIINDHLVVSYLHDVLAKLSIFSMNGENRRDVTLPGEGKVAGPYGKRSKDYFYYVFNSYVQPKTTYRFDFKTGESHIYTEPKVSFNSDDYASKQVFYTSKDGTRVPMMISYKKGMEKNGANPTLLYAYGGFAISLTPRFSPANIAWMDMGGIYAVPNLRGGAEYGEGWHQAGMFDKKQNVFDDYYAAAEYLIDENYTNKTKLGAYGRSNGGLLMGAALTQRPDLFAAVLPAVGVLDMLRFHKFTIGWAWTSEYGSADVAEQFPALLAYSPYHNVTKRSYPATMVMTADHDDRVVPLHSFKFGAMMQAQQQGDAPIIMRIESKAGHGAGKPTSMKIDEFADIYSFLFDSFGLKIPGKVN
>NC_014012.1|WP_013051062.1|2047564_2048434_+|OmpA-family-protein
MWLRVLVASTLCMPFFATAELRHYVASLDQSQWKLSGNTPIICRLEHNIPSYGKAVFTSIAGKNHNLNFTLDMWLKPDKVTQATLMSKAPAWRPGILSKEITELTYQKYFSGEVPRNAAWSMLAELERGMEPTFYYADWYNQSNKIAVGLSAINFNRKYGEFRACLAGLLPYSFDDIAFTVLTYESGGSELTRFSKSQIAKVQEYLAYDSEVELVLIDAYTDSYGGRSINQKVSEQRADSVKNFFLSAGINQDRIYTVGHGERRHVASNATIDERGRNRRVVIRISKPM
>NC_014012.1|WP_013051061.1|2046750_2047422_-|ribonuclease-T
MSEICDANKLNHRFRGYFPVVIDVETAGFNSQTDALLEIAVTMLKMDDEGILSLDKTLHYHIEPFEGANLEPDALAFNGIDPTNPLRGAVSEKEAFLEIFKEVKKAQKAVGCHRSIIVAHNAAFDHGFVSKAIERCALKRTPFHPFATFDTAALSGLALGHTVLAKACSIAGIDFDNNEAHSALYDTERTAELFCHIVNKWKALGGWPLAVNHDIDEASEETK
>NC_014012.1|WP_013051072.1|2059658_2060801_+|porin
MRQAKMSLVAMATMLAVSSGAQAGDTEFKFGGYVKADVMFSDYSNGAPDSGYLSRQFYVPGTIYGDSSNGNQVVDFHARETRFNFKTSTDLDGHKLSGFIELDFMTHGDGNERLSNSYSPRIRHAFVSYDNWTVGQTWTTFQNPGALPENLDFVGAADGTPFARQTMIRYTSGGFQFAIENPETTVTPNGGGGRITSGSGMVPDFIARYNFKTEGGAKFTVAGLARQLNVEIDNLDTQEIAYGVSVTGVIPVGDDDIKLSATAGDGLGRYMALNYANAGVLDANGEIETISSYGGFAAYRHWWTDKWRSSVTLSGFKADNNEALTGGGVNKESYSTYVNLLYSPVKPMTVGVEYMYAENTKQNGDNGDLNRVIFSVKYVL
>NC_014012.1|WP_013051073.1|2060889_2061159_-|glutaredoxin,-GrxA-family
MFVVIFGRPGCPYCVRAVQLSEQLVEARDDFKFKYIDIHAEGISKADLEKTVGKPVETVPQIFIDKEHVGGCTEFEQYVRDNQLLSAPA
>NC_014012.1|WP_013051074.1|2061502_2061991_+|membrane-lipoprotein-lipid-attachment-site-containing-protein
MKKIVILLTAFLALTGCSSNGISNLKQMDANFDKQIVMIDDSKQTASVRSIVTNWIKDHGYDVADTTASTPVQLADNQVLFKFNANWWWDMATYMRYVNLEVTDNKGTSIAKLDFDSVQYGGIDKFGNAEERLNIIMEVFFKQISIKEAEHDLEYGRKSVVQ
>NC_014012.1|WP_041420280.1|2062111_2063860_-|DEAD/DEAH-box-helicase
MFVQLRDYQQQAVDSAVKHFKTSPDSAVLVLPTGAGKSIVIAELARIANGRVLVLTHVKELVAQNAEKVGILTAAAGIYSAGLNQKSTDNKTIVASIQSAVRAKEKFSSPFSLVIIDECHRISQDKDSQYQLLLTHLKSINPKIRLLGLTATPYRLDLGWIYRHHYHGKVGNPDKAVFEQCIFELPMRPLIKRGYLSTPKIFDGLSAQYDFSSIKASTSGQYQEAEVNDLLSHCGRATTAIVKQLVQIGSSRQGVIIFAATVRHAEEILKLLSAEQAALITGKTSTEQRDSLIEQFKARKIKYLINVAVLTTGFDAPHVDLIAILRPTASVSLFQQMVGRGLRICEGKSECLIIDYAANGYDLYFPEVGQNKPNSKSVPVQVHCPVCDFANIFWGLVDDDGDIIEHFGRRCQALIEQEGQKKQCDFRFRSKVCPNCGEENDIAAKICHSCDAMLIDPDKRLKEVLQQKHHHLFKCDAMLFEEDKDRLKIRYIDIDGNDFCQYFNFKTKAQIRAFYAIFVLSHTRTPGLKHPRYSKVQEVIATRDLFRKPDILLLKKHKKGWDLQETFFDYQGRYQTESKFLN
>NC_014012.1|WP_013051076.1|2064016_2065969_-|acetate--CoA-ligase
MSTQSLYKVPSEIAENAHINEEKYKKMYQESIVNPEGFWREHGQRIDWIKPFTKVKKTSFDDHNLSINWFYDGTLNASANCLDRHLEKNADKVAIIWEGDDAKDQRSVTYGELHQDVCKFANALKSQGVRRGDVVTIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPDSIATRVIDGNSKVIVTADEGVRAGRIIPLKANIDQALANPDVTCVERVIVLERTGGNINWQEGRDIKWDTVMETASEHCVPEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYASMTHEYVFDYKDGEVYWCTADVGWITGHSYMVYGPLANGATVLIHEGVPNYPTPSRLGEIVDRHKVNILYTAPTLIRALMAEGKEQFDKFDGSSLRIMGSVGEPINPEAWRWYNEVIGHEQCPIVDTWWQTETGGILISPLPGAIDTKPGSATRPFFGVQPALVDNMGNIIEGAAEGNLVILDSWPGQMRTVFGDHDRFALTYFKTFRGMYFTGDGAKRDEDGYYWITGRVDDVINVSGHRLGTAEIESALVAHENVAEAAVVGYPHDIKGQGIYAYVTLTRGTVESEELRQDLRKWVRKEIGALATPDLIQWAGGLPKTRSGKIMRRFLRKIAANEVTNLGDSSTLADPAVIDVLIESRLNRSE
>NC_014012.1|WP_013051079.1|2069665_2070277_+|fumarylacetoacetate-hydrolase-family-protein
MKTVVVDNRVLRPSKIVCVGRNYVEHIKELNNEVPDEMVLFLKPNSAISTELVSFHQEAIHFEAELCFVVENGHFSAVGLGLDLTKRGLQSRLKAKGLPWERAKAFDGSVVFSEFVAIENISETLTFELMINNELVQVGNIGLMMNKPEQILTEIQSFMSLSDGDIVMTGTPKGVGVVNKGDQFRAKLYDKDLLLTQVNWTAK
>NC_014012.1|WP_013051081.1|2070561_2071221_-|response-regulator-transcription-factor
MKLEKLNIIIADDHPLFRNALRQALSGPFPDTNWFEADSADALQSLLENKQQAYDLVMLDLQMPGSHGYSTLIHLRTHFADLPVIVISAHEDNMTISRAVHYGSSGFIPKSSSMETLAAALASVLYGDIWLPDHAEIQEIQEDATALVARKLADLTPQQYKVLQMFAEGLLNKQIAYDLGVSEATIKAHATAIFRKLGVRNRTQAVISLQQLEMEKVEL
>NC_014012.1|WP_013051082.1|2071443_2071872_-|acyl-CoA-thioesterase
MPLSQTPEDRSSAMNARIEKSEARVIKAIFPSITNHHNTLFGGEALAWMDETAFISATRFCRKPLVTVSSDRIDFKKVIPAGSLAEIIAKVIHVGNTSLKVEVNIFVEDMYRDHREHAIRGVFTFVAVGDDRQPTQVWTQES
>NC_014012.1|WP_013051083.1|2072313_2075703_+|chitinase-C-terminal-domain-containing-protein
MSNKTAYFGRRHRLALIISTSLLSQAVVSQAYAVNCQGVAPWLADTEYASTTQVTQQNSLFQNKWWTTNESPADAGEWGVWQTLGQCDGASNKAPVVNILAPQAGNTVKLNAPLVLNAQATDSDGTVDSLVWTANDIPVTSPWLANLQGAVVLKVTATDNDGASTEQLVNITVTNSQNLSPVTAITAPINDSAVTSGESIIVTANASDPDVGDSIVKVELLVDGAVVSTDTSAPYEFSWIASSTGDHSLQSRAFDSQNDSAVSAMVNILVAAANQLPSVELTSPSANFNLAVNGELSIGANALDSDGDIVSVSFFANGVLIETDTLAPYATLYSATQAGDLSITAEVTDNQGASALSSAILGYVGDRPTSHEACRPDGLEGDSVYCDIYDENGREKMGADHGRRVIGYFTSWRNGTNGQPSYLVNDIPWDKITHINYAFAHIDGNNQVSVGDPNSLENPATGMTWAGVVGAEMDPEYSYKGHFNLLNKYKKLHPQVKTLISIGGWAETGGYFDDTGNRIASGGFYEMTKTQAGINTFADSVVEFLQTYGFDGADIDYEYATSMAKSGNPDDFAIADPLRATLFAQYDTLMKTLREKLDTAGKQDNKHYMLTVAAPASGYLLRGMEAYQMTRFLDYVNIMSYDLHGAWNDFVGHNAALYDTGEDAELAFWDVYSTAQYGGIGYLNTDWAYHYFRGAMPAGRINIGLPYYTRGWQGVTGGSNGLWGKAALPDQASCPSGTGEGDNNCGYGAQGIDNLWHDLDKNGKEMFAGSNPMWHAKNLEQGITGSYLASYGLDPINDPADELTGTYERHYDNVAQSSWLWNPSKQVYLSTEDEQAMNTKVQYVVDQGIGGVMFWELAGDFDWYPERNSGQGEYFIGETMTTIAYDKFASAAPYGNTVSNASALANTLALSANLSGYKVGDSNYPITPTLTITNNSQSTIPGGAVFEFDISTSTSSQISDQSGMNLAVVTDGSNAASGNVGGLENDFHRVRFTLPSYKSIAPGADFGGTIKYYLPVSMPSNFTVSFDGLTYDFGQGGNTVPDACDLEPTAPGCGDTTPPTSDSCSGANIDPSVIPAYPNFPQTDWAGNPSHANGGDRMKDETAVFVALWWTNAKPSASSGDWDFVCNLN
>NC_014012.1|WP_013051084.1|2075887_2078845_+|chitinase
MSHFLTLHKSHFCQSVLAVSLAMSTNLYAQDVAKNTSDHDKDIIGYITQWEPWKDTKAGFVAKGAANHLNVDMSKYTVLNFSFFGVAVDGSLHSGDFRNKNIYKQGTVQQPAELLMGDVYSSWDYFLIFGELSPSYNLTAEAEEQGFVLDGSGWKNTVYGTKGSMPIPVKKAGGAPGLIEKAHANGVKVMASIGGWSMCRHFPEMAADPAKRAKFMEGVDQLMALGFDGIDLDWEYPGPYSGMNFTGTQADFDNFLTLVQEIRERIGADKLISAAFSADTRKLEGFNWAQLELVMDDFNMMSYDFNGGWSNIAGHNSPLYNYEGAEAPNFNWDYLTQWMLDKGIERSKINMGSAFYGRGVVTQDGAVLNGATKKRDVTIQPDGPISTSADYDNWKVEVYDGTPNYFFIKQEEAGWTQHWDDEAKVPYMTKGNYFLSYDDEESIGLKAQYINDQALGGTIVWHVAGDQQCLDGTTTYGGKLVECGSLNPTLVNKLNNVFATGCSGCPTVRITSPNVGDVFSPGDDINFTLEASDADGHITRVDYLNGGIKIGSSAISPFDFRWSSVGEGSYSITALAIDNQGNETESSKMAVEVNEDHLKPKVTVSEPEAKVIQESLTELQLVASAEFDAGSITYVEFSVDGQLVDTVSNGGPSYQTTWLPTHYGAHQLVVTVQNDLGYQQSSSRDFLIVLCDATAWDSSLVYTTQEVLYDGKLYRAKWWNQNQRPDTGDAWELVRDCAPGNVGTQPQVSIDAPLNDAVFAQGELVDVAVNATDSDGEVTEVKLYLDEQLVQTLTQAPYLYQLVNLDSGIHALRAVAKDNSELTSETRVSFTVEGSSAGTEPEIVITSPENGSFVTQGDTLVITADALDSDGTVTKVEFFVAGSLIATSNTSPYQASWTADVTGNISLVVKATDNDGLTNTSAVTIKVEAGTGACSLPEWTASGIYTKGDRVAYSGNQYQAKWWTTNEVPSASGEWGVWEALGACQ

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Crispr_ID: NC_014012_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_8

3263238-3263325

Orphan

Consensus_repeat	Method
AATTATGGGTGGCTTTGTTTGGAATTCGGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014012_8

>merge|NC_014012|8|3263238-3263325|CRISPRCasFinder
AATTATGGGTGGCTTTGTTTGGAATTCGGCTTTGTTTGGAATTCAGCTTTGTTTGGAATTCATGGGTGGCTTTGTTTGGAATTCGGCT

>NC_014012|8|8|3263238-3263325|CRISPRCasFinder
AATTATGGGTGGCTTTGTTTGGAATTCGGCT	TTGTTTGGAATTCAGCTTTGTTTGGA
ATTCATGGGTGGCTTTGTTTGGAATTCGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_013052156.1\|3263362_3264976_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NC_014012.1\|WP_013052146.1\|3250739_3252023_-\|bifunctional-tetrahydrofolate-synthase/dihydrofolate-synthase	unknown	unknown	gnl\|CDD\|182774
NC_014012.1\|WP_013052157.1\|3265927_3266827_-\|HNH-endonuclease	unknown	unknown	unknown
NC_014012.1\|WP_013052151.1\|3259476_3259830_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_041419957.1\|3253056_3256632_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274615
NC_014012.1\|WP_013052152.1\|3259965_3260757_+\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461
NC_014012.1\|WP_013052163.1\|3274181_3274451_-\|YfcL-family-protein	unknown	unknown	gnl\|CDD\|378085
NC_014012.1\|WP_013052150.1\|3257855_3259019_-\|4-phosphoerythronate-dehydrogenase	unknown	unknown	gnl\|CDD\|240635
NC_014012.1\|WP_049791104.1\|3271458_3273588_+\|FAD-dependent-5-carboxymethylaminomethyl-2-thiouridine(34)-oxidoreductase-MnmC	unknown	unknown	gnl\|CDD\|234978
NC_014012.1\|WP_013052165.1\|3275879_3277052_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|372338
NC_014012.1\|WP_013052154.1\|3261638_3262619_-\|transposase	unknown	unknown	unknown
NC_014012.1\|WP_041419956.1\|3252090_3252876_-\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NC_014012.1\|WP_013052144.1\|3249448_3249937_-\|CvpA-family-protein	unknown	unknown	gnl\|CDD\|182773
NC_014012.1\|WP_013052162.1\|3273645_3274185_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349971
NC_014012.1\|WP_013052158.1\|3267422_3269714_-\|U32-family-peptidase	unknown	unknown	gnl\|CDD\|223896
NC_014012.1\|WP_013052149.1\|3256836_3257853_-\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NC_014012.1\|WP_013052145.1\|3250050_3250704_-\|cell-division-protein-DedD	unknown	unknown	gnl\|CDD\|236940
NC_014012.1\|WP_013052160.1\|3270136_3271348_-\|beta-ketoacyl-ACP-synthase-I	unknown	unknown	gnl\|CDD\|181184
NC_014012.1\|WP_041419958.1\|3267170_3267476_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013052164.1\|3274617_3275766_-\|ATP-NAD-kinase-family-protein	unknown	unknown	gnl\|CDD\|225740

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_013052156.1\|3263362_3264976_-\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	2.39316e-109
NC_014012.1\|WP_013052146.1\|3250739_3252023_-\|bifunctional-tetrahydrofolate-synthase/dihydrofolate-synthase	gnl\|CDD\|182774	PRK10846, PRK10846, bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional.	6.55052e-168
NC_014012.1\|WP_013052164.1\|3274617_3275766_-\|ATP-NAD-kinase-family-protein	gnl\|CDD\|225740	COG3199, COG3199, Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only].	2.55728e-94
NC_014012.1\|WP_041419957.1\|3253056_3256632_-\|hypothetical-protein	gnl\|CDD\|274615	TIGR03505, FimV_core, FimV N-terminal domain. This region is found at, or about 200 amino acids from, the N-terminus of FimV from Pseudomonas aeruginosa, TspA of Neisseria meningitidis, and related proteins. Disruption of FimV blocks twitching motility from type IV pili; Semmler, et al. suggest a role for this family in peptidoglycan layer remodelling required by type IV fimbrial systems. Most but not all members of this protein family have a C-terminal region recognized by TIGR03504. In between is a highly variable, often repeat-filled region rich in the negatively charged amino acids Asp and Glu.	1.27953e-28
NC_014012.1\|WP_013052152.1\|3259965_3260757_+\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	1.3255e-63
NC_014012.1\|WP_013052163.1\|3274181_3274451_-\|YfcL-family-protein	gnl\|CDD\|378085	pfam08891, YfcL, YfcL protein. This family of proteins are functionally uncharacterized. THey are related to the short YfcL protein from E. coli.	4.42115e-30
NC_014012.1\|WP_013052150.1\|3257855_3259019_-\|4-phosphoerythronate-dehydrogenase	gnl\|CDD\|240635	cd12158, ErythrP_dh, D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains. D-Erythronate-4-phosphate Dehydrogenase (E. coli gene PdxB), a D-specific 2-hydroxyacid dehydrogenase family member, catalyzes the NAD-dependent oxidation of erythronate-4-phosphate, which is followed by transamination to form 4-hydroxy-L-threonine-4-phosphate within the de novo biosynthesis pathway of vitamin B6. D-Erythronate-4-phosphate dehydrogenase has the common architecture shared with D-isomer specific 2-hydroxyacid dehydrogenases but contains an additional C-terminal dimerization domain in addition to an NAD-binding domain and the "lid" domain. The lid domain corresponds to the catalytic domain of phosphoglycerate dehydrogenase and other proteins of the D-isomer specific 2-hydroxyacid dehydrogenase family, which include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence.	0
NC_014012.1\|WP_049791104.1\|3271458_3273588_+\|FAD-dependent-5-carboxymethylaminomethyl-2-thiouridine(34)-oxidoreductase-MnmC	gnl\|CDD\|234978	PRK01747, mnmC, bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC.	4.17612e-150
NC_014012.1\|WP_013052165.1\|3275879_3277052_-\|MFS-transporter	gnl\|CDD\|372338	pfam12832, MFS_1_like, MFS_1 like family. This family contains proteins related to the MFS superfamily.	1.80818e-113
NC_014012.1\|WP_041419956.1\|3252090_3252876_-\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	6.77344e-146
NC_014012.1\|WP_013052144.1\|3249448_3249937_-\|CvpA-family-protein	gnl\|CDD\|182773	PRK10845, PRK10845, colicin V production protein; Provisional.	3.16897e-77
NC_014012.1\|WP_013052162.1\|3273645_3274185_-\|RNA-methyltransferase	gnl\|CDD\|349971	cd18098, SpoU-like, SAM-dependent rRNA or tRNA methylase related to SpoU. RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	5.61221e-55
NC_014012.1\|WP_013052158.1\|3267422_3269714_-\|U32-family-peptidase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	2.8949e-82
NC_014012.1\|WP_013052149.1\|3256836_3257853_-\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NC_014012.1\|WP_013052145.1\|3250050_3250704_-\|cell-division-protein-DedD	gnl\|CDD\|236940	PRK11633, PRK11633, cell division protein DedD; Provisional.	4.06123e-45
NC_014012.1\|WP_013052160.1\|3270136_3271348_-\|beta-ketoacyl-ACP-synthase-I	gnl\|CDD\|181184	PRK07967, PRK07967, beta-ketoacyl-ACP synthase I.	0

>NC_014012.1|WP_013052154.1|3261638_3262619_-|transposase
MARPRSRLISLEDTPFYHCVSRCVRKNYLMGVDRDTGKSYEHRREWVESRILEIASIFAIDVSAYAVMSNHFHVVLRVDIYEANAWSDREVVEHWHQLFKGTEITQKFTKGELIESYEVSSLKHAIALFRSRLSDISWFMRALNEPIARMANKEDHCTGRFWEGRFKSQALLDETAVLACMAYVDLNPIRAKISEAPEASEFTSIQKRIKAAINGEQPQDLLPFIGNERKEMPKGLMFRAKDYLQLVDETGRIIRDDKRGAISQESMKILNSLNIPQDNWIKLTTEFTRLFKGPVGTLQELDAYCEHLERKRRQGAANCHRWLDTA
>NC_014012.1|WP_013052152.1|3259965_3260757_+|PhzF-family-phenazine-biosynthesis-protein
MELTINVIDAFTDATFKGNPAAVIITENWLSVDLMQSIAVENNLSETAFVKKIDNQHYEIRWFSPITEIDFCGHATLAASFVIFSKSNGLKTINFFAKAVGDLSVTKMDNGYIQMSFPNRKPKVIDDIPLALLNGLSIKPAEVLLNDQGYFVVYEQEADVLNVIPNNELLKQLAPFDVVVTSKSSEYDFISRYFWPANGGDEDPVTGSIHSGLAPYWASKLNKSKLIAYQASKRGGKLICSIEGSKVYISGKAVQYLEGKITV
>NC_014012.1|WP_013052151.1|3259476_3259830_+|hypothetical-protein
MNIKKWMWEITTISVVCVLLLNPELVSLALFVDAVGLDIFLLLIEVQLVAVSGYYFHTWFKPILMPFYRCLLKVDPYFFIPTKDSVGKYPMILCHVVPFLMLLIIGVTVAKPVIDIA
>NC_014012.1|WP_013052150.1|3257855_3259019_-|4-phosphoerythronate-dehydrogenase
MKILADENMPYVQELFGDLGTIETVNGRELTPEQVKDADVLLVRSVTQVNGSLLSLNNKLKFVGSATIGTDHIDTDYLASRDIPFSNAPGCNATAVGEFAFIAMLELANRFGGKLKDKTVGIVGAGNTGSAVAKCLQAYGVTVLLHDPVIQDSDPRDFISLDELIARCDVISLHVPIIKTGEHKTWYLFDETRLNSLKPGTWLLNCCRGEVIDNRALIKVKQQRPDIKLVLDVWEGEPNPMHELIPLVELATPHIAGYSLEGKARGTYMLYQKLMQVLGRDADKSMTTLLPSLWSVQLDIESIPNEKSLLKLARFIYDLRDDDELFRKTILDDSSKNDQVNCVNNNGFDLMRKNHQHRREFRALRLVNTGHSDVNWLTNLGFSGVGQ
>NC_014012.1|WP_013052149.1|3256836_3257853_-|aspartate-semialdehyde-dehydrogenase
MSQEFNVVVLGASGAVGQTMIEILEERNFPVAKLFPLASSRSAGGTVSFNGKQVEILDVDDFDWSQAQIGFFSAGGDVSEKWAPIAAENGCVVIDNTSQFRYDNDVPLVIPEVNPEAIADFRNRNIIANPNCSTIQMLVALKPIYDAFGISRINVATYQSVSGSGKEAITELAGQCSKLLQGLPAESKVYPKQIAFNVLPQIDKFMENGYTKEEMKMVWETQKIFGDDNIVVNPTAVRVPVFYGHSEAIHLETIQPAEAEDVKAVLREAPGIELFESNEEYPTAVTESAGTDPVYVGRVRKDISHSHGINLWVVSDNIRKGAALNSVQIAEVLIRDYY
>NC_014012.1|WP_041419957.1|3253056_3256632_-|hypothetical-protein
MNFRTSYLVGLMASTLLVFTVSPLIQTAFAAEPLKITGPDGEVRQTNRQYGPTLSSDTFWSIAQKVRPDNSVSIYQVMAAIYDANPHAFTNANYNSLEKGMILLIPSKDLMLAIPRSMAKSRAERDDKGWKKTTQPKAVQVAQVKQATPSTPARPVTLPITPADTSVAQKPTVNEEIKELTAKLEEEEAKSLQLTDELGRAQDRLELSDSDTGTLKNKIDELKEQVAILEEQLLASKLQGAGLGEEVNSLQEQINALQIVEPEADPEQWRNLMSNPLMLIAAISIPALLLLLILWLFLRRRRDEGAASTEEKTTKETESPITAETDADTGAEALGSESHDLEAMAVHLDTEDDDSIDSLMNIDTAELQPEVDMSSDEQDLAGDMFVDPGETATEEPAEEEGQSLDDLWAEAMGEQDEEEAKAGEDDLDSLLAGFDEEPAKDEAPAEEASIELSPVEEALVAESIEASIEASSAADPSSEIVSEDDLDSLLEGFDEPADASSTQAETETASEIESESDGVAEDDLDSLLAGFDEPADTSSTQAESETESDGVAEDDLDSLLAGFDEPADTSSIQADTEIESESEAQTDLASEDDVSGSLSEEIAAELEQDITPTAEDDALDAANIEKLGVEKDSEEDVDALLAGFEHSEEDTSTETPVEDADLSEAISAELEGEVDTSADADAADLDALLAEFDEKPDVSATAEDDTELEVTELEVTEVEATPVEEAPAETAAELDTDLTDAISAELEGEVDTSADADEADLDALLAGFDENSAAPAAEFDTDLTDAISAELEGEVDTSADADEADLDALLAGFDENSAAPAEDYSLENTEVAAIELEDTEREDKPVEEDPAGTAAESDADLIDEISAELEGDVDTTADADEADLDALLAGFDENSAAIAAEPDADLTDEISAELEADIDTNIGDSEDDLDSLLAEFDIADQLDKPEVLDDSLLAPATEPSPEREPSSDDALDSLLADLEAVDPKSAKDPVASKPGGGMFADLKGAKKIDDTSLDWEPSANVEEPVIAPANNEELLSSLLDVKEQSGHSEMSLSLEGEGNLTVDEALAALDAEDLSKSPAVAVAEHDLTSFQKDNGFIDIDRLLNEAEEDVTDIDQYKELDVDMGEIDKLMGNPAMVDVDDEENSINAKLDLARAYIEIDDNDSAKVLLKEVQLDGNDRQKDEADGLVNSLD
>NC_014012.1|WP_041419956.1|3252090_3252876_-|tRNA-pseudouridine(38-40)-synthase-TruA
MRVALGIEYDGSKYYGWQRQLEVDTVQAQLERALSKVANQPITVHCAGRTDAGVHGTGQVVHFETTAIRKESAWTLGVNVNLPDDIAVKWVKLVDDDFHARFSATARRYRYLIYNYHLRPGILRSGVSHYRGQLDENKMHQAAQHFVGEHDFTSFRALHCQSKSPFRHVHEVNVTRQGMYLCVDIKANAFLHHMVRNIVGSLIEIGQGHQQGDWIVELLALKDRSKAAPTAKPNGLYMVDVTYPDKYELPKLALGPLFMLD
>NC_014012.1|WP_013052146.1|3250739_3252023_-|bifunctional-tetrahydrofolate-synthase/dihydrofolate-synthase
MPTVPTQDSSLDTWLDYLLAIHPTEIEMGLGRVAQVAERLGLKDLGTTKVITVAGTNGKGTTCAMVEQVLLLSGERVGVYSSPHMLKYNERVRIDGQDVDDRSFIQAFDAINLARGDISLSYFEFATLAGLYIFKAAKLDTVLLEVGLGGRLDAINIIDADIAVITSIDLDHQEYLGDTRESVGMEKAGILRANKPAIIGEPNLPTCVLEYANELGAVLHRVGKEFSYTCEAVFWQFTGLQTMNDIPMPSLPLPNAATALALLELGWPQLSGDIIRQGIQEARLTGRLEVVSEQPLVLLDVAHNPHAARYLAKQLEKHPAKRLFAICGMLKDKDCRQVIEVLAPLVDVWSFTSLQTDRSASGEGLKKIFVEQVQQISHPLAYAKHFDSVESAWRTISAEICQGDVVIVFGSFYTVAEFKNIELDGRD
>NC_014012.1|WP_013052145.1|3250050_3250704_-|cell-division-protein-DedD
MSGHFQNRLVGVIVFVALGVIFLPDVLDGKKVQQEEQFSEIPLRPQVAEITLPDEAIQAVDLSDKEQAFKSEEQTADSGKWEVVEAEPKPKPHKPTASTHVKPHSKPEIKPTPKPVVKPVAKPIKKPVVKPVTPTSSAYTLQLGSFKNAANVKGLISKLRSGGFSAYTLPTHPVDGKLTKVFVGPEISKSKLQSLQPGVEKLTKLKGRIVSYRPTAS
>NC_014012.1|WP_013052144.1|3249448_3249937_-|CvpA-family-protein
MVWIDYAILAVIGVSTLISLLRGFAKEAMSLVVWFGAFFVASHFYQALAVHLTQMQDEFLRNGVAIAIIFVATLILGALINYLIGQLIDKTGLSGTDRVLGLCFGALRGALIVSAILFFMDAFTGVSHMDWWQDSKLVPEFGVVIQWFFDYIENTSSFVPKI
>NC_014012.1|WP_013052156.1|3263362_3264976_-|EAL-domain-containing-protein
MSFNMTNKKPIPLHRKLFYKMFDSAFSREISFIFILSVILLIICVNIDAFEKLVDFVEYYEYYELDEIVMLVLISSISFMVIIIRNVKHLNVEIKLRIKSENKLNKLAFFDPLTGLPNRALFKNKLEQFVSRDKESMQLGAVLYIDLDDFKNINDSMGHAWGDELLKKFSERLQIQLRTYDTLFRISGDEFTVIIGSPINIHGISTLAEKLIESLKAPFILDREEVYTSMSVGVAVFPTDAQTAKGLLKCADTAMYSAKHEGKGHYRYYSIDLDKQAKLKLKISNKLRRAIELEEFTLNYQPIIDIETQEVKGAEALLRWNNKELGCVGPDIFIPIAEEIGLINEIGNWVLRQACWQNKQWHLAGYSYLMMSVNMSSKQLVNDDFINVVNNALVKSQLEGSYLELELTETALLGNLEIAIEQIYRLKKMGVCIALDDFGTGYSSMSYLVKLKIDRLKIDKSFIDNIPHSEDDRITTHAIISLANNLNLQVTAEGIETEEQYKYVKSTSCNAAQGYYFSHPLTADNFKFLLDKSPTFS
>NC_014012.1|WP_013052157.1|3265927_3266827_-|HNH-endonuclease
MNKLFIEFLNKPRAKLWFKQRPHMIHLFEHIFNQLSNIYDHDKINDRFIRSQNKRVPHLLFNLNAKNQEVADNPNSEFGNAIWIKPRYNTSKLTDQYIVHVEVAISFKEHHHHFISFHSGIKSLINSIKENKLKNFDFEGDYVGEEFINTMMDTVPAEDLSLIERLNKDTKKYFKRFPRRQNDFRRLIRNIEREHNITGVKAMEKNCVSSHIKPFSHCKNYEEAHDEYNGLWLEKKMDQLFDKGYITFTKDGDVIVGSACSDELLVHLKLKRHEIHNISPLLKEQLVYMEYHRNAVFKP
>NC_014012.1|WP_041419958.1|3267170_3267476_+|hypothetical-protein
MTRNRRDTYPETRAGANAVVTFRDMDVMAEAIGIYSRRVTEVFALKPTAGDGFDRSNTIQKANETTIKPNETTADTSSNLLSYKLQAIVVLQYRRFRHYIA
>NC_014012.1|WP_013052158.1|3267422_3269714_-|U32-family-peptidase
MDPKIELLAPGGDVDAIKAAIIAGADAVYCGLDTFNARNRAANISFEELVGIIRLAHQYQCQIFLTLNIVILENEFKSLAKLLSKLVNTTLDGVIVQDIGMFHLLTKHFPTLDIHASTQLTTHNIGQIPFLKKLGASRVNLSRELNLREIAALTETGRENDITTEVFVHGSLCIAFSGLCYSTSASVGNSGNRGRCSQACREEYETTESGHNFPLNIKDNSAFFDLPALIEAGVHSFKVEGRIKGASYVHTVIDSFRKQIDGFLATGELLEDGERLYKVFNRDLTNSFLKGDLNQSMFIDNPRDNSKNHLKDKLTHNGLKSISVVQIHDAEQELQTEKSQIQASVNDKIKHLSIEKLPLTLSFSGQLGQPLTITVSTQDFIIGQTQLEDKTFTVQSPSLLTLSDDASIDASSIEKRFKSLNNAEFDLLQLVTDDLAPGLSIPFKELTGLKKQVLLLLNHETPVLPAVELPKLARYPKPETHRPKLSILICDEADIALADVTDADIYFKLPDAYKRGCTKYVEFFKQNPRLIPWFSSVLIGKDFDAALNILEQVRPKLIVTNNTGIANRAYELGIKWIAGPFLNTTNSYALLAMQEQFDCHGAFISNEINQNQIKHIARPANFKMLYSIYHPILLMASRQCFFQQSVGCEKPRIDNGCMLSCDKSTSITNLKGDEFAIDKQKAGYPSIYNQDQFLNTEIIEDLAHLFDGFMIDLTNIGAGDKPSPDKELLIQQFELLLSGQSNLATSLGNIVPKSTVLQYHNGL
>NC_014012.1|WP_013052160.1|3270136_3271348_-|beta-ketoacyl-ACP-synthase-I
MKRVVITGLGVVSSIGNNKQEVTESLKAGRSGITHSAQFEEMKLRSRVWGEITLDPKEHIDRKALRFMGKAAAYAYVAMAEAIKDAGLTEEQYSDPRVGIIAGTGGASSANQVQAADILREKGVKRVGPYIVPRIMSSTASACLATPFKIKGMNYSISSACATSAHCIGHAAELIQMGKQDMVFAGGSEEVDWTLTMGFDAMGALSTKYNDEPQKASRTYDADRDGFVISGGGGIVVVEELEHALARGAKIYAEIVGYGASSDGYDMVAPSGEGAVRCMQMALADVDTPIDYINTHGTSTPVGDMRELEALRETFGDSLPPIASTKSLTGHALGAAGAHEAIYSLIMMEHGFIAPSINIDNLDEKAAGMPVVTEYREAELTTVMSNSFGFGGTNATLVMKKYK
>NC_014012.1|WP_049791104.1|3271458_3273588_+|FAD-dependent-5-carboxymethylaminomethyl-2-thiouridine(34)-oxidoreductase-MnmC
MPKVRRRVNSLTQEREEKMVNNHNCSHFDSFHEQIAKMYPDKKKLSLGQIGLCDAQQLLSVILLQQKSLPDTRLYVKIFESDCSAVERINLQLAALQTQNQECEELAHADLSFGSGSYLDMQAAIKQLLDTKLVAIPGCQRLILNQGRCLIDLYLGDIHSSLTNILAPADPASYLHAWFHTSDQQSLDEQVLWQMAKVSSNTALLSSSYISQQQANLAQIAGFTLTDLTSADFLSTGSLLEASAPEKTDLPPVSAKLNNEISQQERRALRQAQANEFQHYPQLPAKEGTIAVIGGGIASTHLALSLAERNKTVQIFCQDAGFSQQASGNKQGAIYPLLTPDNGTLSQYFQQGLLFSRRRLTSLVDEGFNIANQLCGVLHTGHDERSRGRINRIISAQAWPKEIAHRVSAPEATSLASIDIDQEGVFYPLGGWISPPEFTQAAFDKAAKIADVSALFNANITRIEQNEGQWYLYQDSCSGSGSENDSDNEVKHGPFSTLVLANGHGLTQFEQSKLLPATGFRGQVSHIPARNELAKLTTVLCSHGYLTPSNDQLHCTGASYVKNPQDLDYCPNEQLDNLKKMQHSFEGKTWVDDIDITGHSARVGVRMVTRDHAPMLGCAPDTDLMLENYKQHQHTKASIQFWKNNPAPIHHGLFILGGLGSRGITTGPLAAEALAAQLCGEIIPLDMATLALLNPNRMWMRKLIKGKAL
>NC_014012.1|WP_013052162.1|3273645_3274185_-|RNA-methyltransferase
MTTCANRTSLVKIGLVNPKSPTNVGGVMRAAGCYQANEILYTGKRYALAAKHRGEQYNTDTKRVGQHIPLTATDDLLLARTDGVKLVCVDLVVGAIPLPEFVHPDKAIYVFGPEDGTIDQALIDEADAVVYVPTIGCMNLASSVNVLLYDRLAKTNMQIANDALIRQSRDNNNRVKVKQ
>NC_014012.1|WP_013052163.1|3274181_3274451_-|YfcL-family-protein
MLEQYETSLYEWIDDIVAKGDEDALFASGYLQGHFAVAISQLEVEAVQGIAALGEKMDVCLQLAKKELDDADFALVASAWQQLNEKLSA
>NC_014012.1|WP_013052164.1|3274617_3275766_-|ATP-NAD-kinase-family-protein
MAIRFRLGLIINPFAGLGGSVALKGSDGVAEEALARGAEPKAQLRMQQALEVILPYQDKIEVITASGDMGETLAKEMGFDVRVVHQVSGKSEAGDTQLVVKHLLNEELDLLLFAGGDGTARDIYCVADENMPVLGVPAGVKIHSGVYGITPHASGMVVKMLLDGDLVSLMSADVMDIDEVAFRKGTVRAKCYGEMLVPAEPRYIQAVKMGGIEIDELVLSDIAAEVIENMEDELYIMGSGSTVAALMSELQLENTLLGVDVVQDSRVIGADLGAKQLLDMTRDQPVKLVITLIGGQGHILGRGNQQLSSELIKRVGKDNIIILATKTKLKALEGRPLIVDSGDPELDKDLCGYYRVITGYHDYVMYQVANPDLNLDSRAITG
>NC_014012.1|WP_013052165.1|3275879_3277052_-|MFS-transporter
MDQTSQVSTQLRWISACYFFFFAILGVMVPYLGVFFENRGFDPQEIGFLLAILMATRIIAPNVWAMVADRTGMRAQLVKWGAAAASVSYLTFFYDGSFTYLAVSLCVYTFFWNSILAQLEVITLETLGENTSRYGAIRSFGSLGYLVFVVAVGFGISVWGTEILPYVGMVLFIGLLLSTLPLPSKRALVKAKGDTPKLTLDKGIIWFLISAILLQMSAGPFYGFFVLYLKQAGYTEAVAGIYVALGVLAEILMFMIAPKLLSRFGVKRLLVASLGFTGIRWLLMAYLVDSFIWLGVSQLLHAFTFGLVHAASIQFVHSRFDANHRSKGQALYASLSFGVGGALGTWLCGMIWGDGSGAYLAWIGAAICAFLAMLAVYFIPKQVKSIKQTG

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Crispr_ID: NC_014012_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_9

3459868-3460133

Orphan

Consensus_repeat	Method
AGGTTGAGATCTTTTTCCATCTCTTCATAGGA	CRT

3 spacers

The CRISPR arrays of NC_014012_9

>merge|NC_014012|9|3459868-3460133|CRT
GGCATGAGATTACCGAGTATCTCTTCATAGGACACGAGATTGCCGGACATTTTCTGTAGTAGCTGAATAGTTAAAGGTTGAGATCTTTTTCCATCTCTTCATAGGAGATGAGATTGCCGGACATCTTTTCTATTACCCAACGTTACTAAGACCAAGCTATAAGTTCAGATCTTTTTCCATCTCTTCATAGGACACGAGATTGCCAGACATTTTCTGTAGTAGCTGAATAGTTAAAGGTTGAGATCTTTTTCCATCTCTTCATAGGA

>NC_014012|9|2|3459868-3460133|CRT
GGCATGAGATTACCGAGTATCTCTTCATAGGA	CACGAGATTGCCGGACATTTTCTGTAGTAGCTGAATAGTTAA
AGGTTGAGATCTTTTTCCATCTCTTCATAGGA	GATGAGATTGCCGGACATCTTTTCTATTACCCAACGTTACTAAGACCAAGCTAT
AAGTTCAGATCTTTTTCCATCTCTTCATAGGA	CACGAGATTGCCAGACATTTTCTGTAGTAGCTGAATAGTTAA
AGGTTGAGATCTTTTTCCATCTCTTCATAGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_013052319.1\|3456745_3457108_-\|HNH-nuclease-family-protein	unknown	unknown	gnl\|CDD\|236895
NC_014012.1\|WP_013052324.1\|3460904_3461723_-\|phosphate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|184582
NC_014012.1\|WP_013052317.1\|3455001_3456180_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_041419975.1\|3461812_3463465_-\|phosphate-ABC-transporter-permease-PstA	unknown	unknown	gnl\|CDD\|227318
NC_014012.1\|WP_041420390.1\|3448943_3450650_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236443
NC_014012.1\|WP_013052310.1\|3445709_3447242_-\|S41-family-peptidase	unknown	unknown	gnl\|CDD\|143475
NC_014012.1\|WP_013052329.1\|3467670_3468075_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380364
NC_014012.1\|WP_041419972.1\|3447313_3447787_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_041419977.1\|3468229_3470383_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_014012.1\|WP_013052333.1\|3472845_3473274_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013052315.1\|3451811_3452861_-\|3-oxoacyl-ACP-synthase-III	unknown	unknown	gnl\|CDD\|181732
NC_014012.1\|WP_013052326.1\|3463612_3465868_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226956
NC_014012.1\|WP_013052331.1\|3470880_3471810_+\|triacylglycerol-lipase	unknown	unknown	gnl\|CDD\|224001
NC_014012.1\|WP_041419974.1\|3453108_3454374_-\|methyltransferase	unknown	unknown	gnl\|CDD\|379330
NC_014012.1\|WP_013052327.1\|3466037_3466538_+\|amino-acid-binding-protein	unknown	unknown	gnl\|CDD\|225337
NC_014012.1\|WP_041419976.1\|3466791_3467607_+\|DUF2797-domain-containing-protein	unknown	unknown	gnl\|CDD\|378524
NC_014012.1\|WP_013052332.1\|3471812_3472787_+\|lipase-chaperone	unknown	unknown	gnl\|CDD\|377013
NC_014012.1\|WP_041419973.1\|3447845_3448940_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187673
NC_014012.1\|WP_013052318.1\|3456403_3456652_+\|DUF1289-domain-containing-protein	unknown	unknown	gnl\|CDD\|377738
NC_014012.1\|WP_013052314.1\|3450810_3451698_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|235135

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_013052319.1\|3456745_3457108_-\|HNH-nuclease-family-protein	gnl\|CDD\|236895	PRK11295, PRK11295, HNH nuclease family protein.	3.7371e-75
NC_014012.1\|WP_013052324.1\|3460904_3461723_-\|phosphate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|184582	PRK14236, PRK14236, phosphate transporter ATP-binding protein; Provisional.	0
NC_014012.1\|WP_041419977.1\|3468229_3470383_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	3.11178e-64
NC_014012.1\|WP_041419975.1\|3461812_3463465_-\|phosphate-ABC-transporter-permease-PstA	gnl\|CDD\|227318	COG4985, COG4985, ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism].	1.06466e-89
NC_014012.1\|WP_041420390.1\|3448943_3450650_-\|AMP-binding-protein	gnl\|CDD\|236443	PRK09274, PRK09274, peptide synthase; Provisional.	0
NC_014012.1\|WP_013052310.1\|3445709_3447242_-\|S41-family-peptidase	gnl\|CDD\|143475	cd06567, Peptidase_S41, C-terminal processing peptidase family S41. Peptidase family S41 (C-terminal processing peptidase or CTPase family) contains very different subfamilies; it includes photosystem II D1 C-terminal processing protease (CTPase), interphotoreceptor retinoid-binding protein IRBP and tricorn protease (TRI). CTPase and TRI both contain the PDZ domain while IRBP, although being very similar to the tail-specific protease domain, lacks the PDZ insertion domain and hydrolytic activity. These serine proteases have distinctly different active sites: in CTPase, the active site consists of a serine/lysine catalytic dyad while in tricorn core protease, it is a tetrad (serine, histidine, serine, glutamate). CPases with different substrate specificities in different species include processing of D1 protein of the photosystem II reaction center in higher plants and cleavage of a peptide of 11 residues from the precursor form of penicillin-binding protein; and others such as tricorn protease (TRI) act as a carboxypeptidase, involved in the degradation of proteasomal products. CTPase homolog IRBP, secreted by photoreceptors into the interphotoreceptor matrix, having arisen in the early evolution of the vertebrate eye, promotes the release of all-trans retinol from photoreceptors and facilitates its delivery to the retinal pigment epithelium.	1.35418e-05
NC_014012.1\|WP_013052329.1\|3467670_3468075_-\|cupin-domain-containing-protein	gnl\|CDD\|380364	cd02236, cupin_CV2614-like, Chromobacterium violaceum CV2614 and related proteins, cupin domain. This family includes mostly bacterial proteins homologous to CV2614, a Chromobacterium violaceum protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.71415e-46
NC_014012.1\|WP_013052315.1\|3451811_3452861_-\|3-oxoacyl-ACP-synthase-III	gnl\|CDD\|181732	PRK09258, PRK09258, 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed.	0
NC_014012.1\|WP_013052326.1\|3463612_3465868_-\|ABC-transporter-permease-subunit	gnl\|CDD\|226956	COG4590, COG4590, ABC-type uncharacterized transport system, permease component [General function prediction only].	0
NC_014012.1\|WP_013052331.1\|3470880_3471810_+\|triacylglycerol-lipase	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	1.51508e-53
NC_014012.1\|WP_041419974.1\|3453108_3454374_-\|methyltransferase	gnl\|CDD\|379330	pfam13679, Methyltransf_32, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.02467e-19
NC_014012.1\|WP_013052327.1\|3466037_3466538_+\|amino-acid-binding-protein	gnl\|CDD\|225337	COG2716, GcvR, Glycine cleavage system regulatory protein [Amino acid transport and metabolism].	9.65713e-24
NC_014012.1\|WP_041419976.1\|3466791_3467607_+\|DUF2797-domain-containing-protein	gnl\|CDD\|378524	pfam10977, DUF2797, Protein of unknown function (DUF2797). This family of proteins has no known function.	5.38847e-147
NC_014012.1\|WP_013052332.1\|3471812_3472787_+\|lipase-chaperone	gnl\|CDD\|377013	pfam03280, Lipase_chap, Proteobacterial lipase chaperone protein.	3.59109e-39
NC_014012.1\|WP_041419973.1\|3447845_3448940_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187673	cd09813, 3b-HSD-NSDHL-like_SDR_e, human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs. This subgroup includes human NSDHL and related proteins. These proteins have the characteristic active site tetrad of extended SDRs, and also have a close match to their NAD(P)-binding motif. Human NSDHL is a 3beta-hydroxysteroid dehydrogenase (3 beta-HSD) which functions in the cholesterol biosynthetic pathway. 3 beta-HSD catalyzes the oxidative conversion of delta 5-3 beta-hydroxysteroids to the delta 4-3-keto configuration; this activity is essential for the biosynthesis of all classes of hormonal steroids. Mutations in the gene encoding NSDHL cause CHILD syndrome (congenital hemidysplasia with ichthyosiform nevus and limb defects), an X-linked dominant, male-lethal trait. This subgroup also includes an unusual bifunctional [3beta-hydroxysteroid dehydrogenase (3b-HSD)/C-4 decarboxylase from Arabidopsis thaliana, and Saccharomyces cerevisiae ERG26, a 3b-HSD/C-4 decarboxylase, involved in the synthesis of ergosterol, the major sterol of yeast. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid sythase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.93815e-77
NC_014012.1\|WP_013052318.1\|3456403_3456652_+\|DUF1289-domain-containing-protein	gnl\|CDD\|377738	pfam06945, DUF1289, Protein of unknown function (DUF1289). This family consists of a number of hypothetical bacterial proteins. The aligned region spans around 56 residues and contains 4 highly conserved cysteine residues towards the N-terminus. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids.	4.11139e-16
NC_014012.1\|WP_013052314.1\|3450810_3451698_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|235135	PRK03592, PRK03592, haloalkane dehalogenase; Provisional.	1.74948e-45

>NC_014012.1|WP_013052319.1|3456745_3457108_-|HNH-nuclease-family-protein
MSVSQGQSKLDKVLAAARDYKAKRETGYREQALKLYPWVCGRCTREFVHSNLRELTVHHKDHNHDNNPSDGSNWELLCLYCHDNEHSKFEELIQYGATTETKVESATYNPFANLKGMMKK
>NC_014012.1|WP_013052318.1|3456403_3456652_+|DUF1289-domain-containing-protein
MIHSPCVAKCGLNDEDICMGCYRTIDEIVAWGTGDDGFKADVWVKLAKRKAEQAKGELGESNSISRKKWQEAEARIALNSTE
>NC_014012.1|WP_013052317.1|3455001_3456180_-|hypothetical-protein
MKALLRLSVFVVLGLLTSACSLLEVKFESAVVPLPQEQLNMRVFSRDFSSTFYSQVEQTADQVSALESIDEQDIQLRSNALMWKINAEQALQRTIFQSSPVAAMLDTWAFTAQMSDFYETGAGKTLFGAQQAQVIETSRALEAQFEKTVKGFLSQADFNKNREFIQKYVVDNPLTDITFSRKSAFNDWLIFREVNEFEAVTTFGSVPEVMSDVSDRMAMISEQMPKLLGWKAELYALHSNINAEDVQATLVSISDTSAKFQELMAQSPEMMQNLAVDMRRELTPLLQQLSDSTDDKLVQLSVERQALELMVKNERLALEDMVVRERIAAAANLDEISKHTVEVVFQELTKTLKSLILYFVLFLVVVFFAPLGLGVFLGKRMESKKANKAIKS
>NC_014012.1|WP_041419974.1|3453108_3454374_-|methyltransferase
MSAYTLQETFHRQRLKQLDTLLVQSRELWQVKAFDCIQLPWEKHFPSLAEKVWSIADVDIDKLDKVQAKLNAELLPALQRDLDRNESPWQLDLLQQVLADKDSSQKQPLTNLLSDKEASHFSTGIKGRKWSQITAFTAQIKQDSSEVLEWCAGKGHLGRFIAKAHSRPVISLEWQRSLCDEGTKFADKWHLPQRFICADAFAPQQSKLKRDQQVVALHACGDLHVRLLRLASQANTRSIMISPCCYHLIQAERYLGMSEVVLESELVLSPHDLQVPLQHSTIANAKQVEYRHKEIVWRLGFDSLQREVNRSTRYLPIPSIKQSQLNNGFAAFCYWAAEKKSVVLSEDLDVNVYLELGVQRHRLTRRIDLVAHLFRAILEHWLLLDRVCFLEERGYSVKLTKFCSEAITPRNALILAEKPEN
>NC_014012.1|WP_013052315.1|3451811_3452861_-|3-oxoacyl-ACP-synthase-III
MKYSRVFINSLAYELAPEVVTTSELESRLAPLYKKFRIPMGQLAALTGITERRWWPKGHRLSDGALAAAHKAIDETGVKVSDLGAVVYTGVCRDQHEPATACRIAAELGVSKNTAIYDISNACLGVLSGILDIANRIELGQIKAGLVVSCESARHIVDITIDNMLADQTMQNYAQSLATLTGGSGAVAVLLTDGSLPLNTDRQHQLLGASHLSAPEHHNLCQWGLQEAGLQLYREFMRTDGVTLLKEGVELARHTWSHFLEQRDWVVEQVDKVICHQVGSANRLKVLNALDIPPEKEFPTYQLLGNMGTVSLPVTAAIAHDQGFLQKGDQVSFLGIGSGLNCMMLGIKW
>NC_014012.1|WP_013052314.1|3450810_3451698_-|alpha/beta-fold-hydrolase
MLDTLFPFKRNYLDRNGHKLQYVNEGQGEPVVMVHGNPSWSFYYRNVVSALSSNHQCIVPDHIGCGLSDKPDDSGYDYTLKNRIDDLEALLEHLDVKENITLVVHDWGGMIGMGYAARYPERIKRLVILNTGAFHLPQSKPFPWPLWICRNTLLGTALVRGFNAFSSIASYVGVKRKPMPSEIRKAYVAPFNSWANRISTLRFVQDIPLKEGDRNYELVSEIAASLPKFANVPTMICWGLKDFVFDKHFLAQWKVEMPHASVHEFADCGHYILEDASDEVVGHITQFMNSDSTAV
>NC_014012.1|WP_041420390.1|3448943_3450650_-|AMP-binding-protein
MHTRAAANLCRHLISAASHSPDDLAVVVQTAMGSFFSAKTLEYQELNFSELNQQSDRLAHGLNAYGITRGMKAVLMVTPSVDFFTLTFALFKAGVVPILVDPGMGVKNLKQCFIESEPDAFIGIPKAHLARKLFGWGKRSVKHLVTVGGRSLFGGVTLEELAALGSSEPYEMIWLDQDEMAAILFTSGSTGTPKGVVYSHKMFEAQITALRDDYGIEPGERDLATFPLFSLFGPALGMASIIPEMDASKPIKANPDYLFAAIEKYQCSNMFVNPALIERLGQAGVQAGQGIDMIQHKLPSIKRVISAGAPATISSIKHFSKMLSDGVEVLNSYGATESLPLSKMGSQALFNTTAITDDGGGICVGEAISGVDIAIIEINDNPIIHWSESLRLEAGKIGEIVVKGPMVSRSYYRRDSATEQAKIKDGDMIRHRMGDLGYLDSEGKLWMCGRKAHRVDASCGKRYFSIPSERIFNTHPQVKRSALVGVEITRDAGIPELVPLLCIELDKSLACSLGASLYAELNAIAEQHSQTLGIKRFLIHPEFPVDIRHNAKIFREKLAVWAQKKHKE
>NC_014012.1|WP_041419973.1|3447845_3448940_-|NAD-dependent-epimerase/dehydratase-family-protein
MLASHVSVKSQLASPVLEEFHTLEQAALAALKGKASHGFVTGAGGFLGKAICQRLLAAGIKVTGFARGDYPELTAMGVIMVRGDIADKTAVLDAMKGCDLVFHVASKAGVWGSKQSYFLPNVDGAANIISACQQLKISKLIYTSTPSVTFAGEDESGIDESAPYAANYLNHYGESKAVAEQMVLEANSQALKTTALRPHLIWGPEDPHLVPRVIERAKSGRLKLVGKEDKLVDTIYVGNAAYAHILAAVNLCSEDASAAGKAYYLSNDEPITMAAMLNKILACVDLPEVTKRVPAGLAYAVGVVLESVYGCLGKTDEPMMTRFVAKQLSTSHYFDISAAKTDFGYSPIISIDQGMVKLTEYLKS
>NC_014012.1|WP_041419972.1|3447313_3447787_-|hypothetical-protein
MLAPSRPLLSVLVSISLVFSLLSLSSRALASELMVNPFIGSWQLESGKYLDDKGEWQDYKKLNLQAIKVISSSHFSFTTMKEIEQADGENKQEFWAAGTGRYEFTDSLYIEYPQLNSFGVTPGESFAFEYQIKGQELHTKRIEEGVLKEVEVWQRLD
>NC_014012.1|WP_013052310.1|3445709_3447242_-|S41-family-peptidase
MLKPLSFALTLGASLSLVFYTSDVSAEAANTASIEAVKDGSNNPWAQLAVTDLKQIYQTVKADHPGAVDDDNPYFSDWLEQGYREGITRANQAESLQDTLNTLRYYVSGFADGHFGLSLNYQARTQTWVGIGLAKRGRDYRVSYQEKNWSSELPPLGASLISCDGRNPSKIMNDEILKYRFNNLEVNSKKIRYAKKILIDDGIGERTHPETCLFEISGKQQSYKLSWKKTSTTKLINKLKLGNLPSQFELIEFKPNHYWVTLPNFYPNADEEVQLKAIIKQMKALRNAELLVFDVRGNGGGSSQWGVNLASELYGKEYIDNVIEHAPDNSYALWRVSSENIAYLESINGSILTQFGADSEIFKEFYQTGQDMKASLLSGDIFVKEASSSEESETSSKVTPKLITEPSLYKGKTVLLTDSYCGSACLDFADLSLSIPGLVHMGEETSADTVYMDVRMVTLKSGLGRFSLAQKVYRDRPRANNQSYIPQYLYQGKMTDTDGLQKWVVESLAE
>NC_014012.1|WP_013052324.1|3460904_3461723_-|phosphate-ABC-transporter-ATP-binding-protein
MISIDKSAMSTKFVDLKNLSQEDTALEIRNLDLKYGDKQALFDVSMKIPEKQVTAFIGPSGCGKSTLLRCINRMNDLVDNCHISGDVLLHGQNIYDKKIDVAALRRNVGMVFQRPNPFPKSIYENVVYGLRLQGINNRRDLDDAAERSLRGAAIWDEVKDRLHDNAFGLSGGQQQRLVIARAIAIEPEVLLLDEPTSALDPISTLIIEELISELKSKYTVVIVTHNMQQAARVSDQTAFMYMGELVEYADTNTIFTTPQKRKTEDYITGRYG
>NC_014012.1|WP_041419975.1|3461812_3463465_-|phosphate-ABC-transporter-permease-PstA
MGNWFKSGSPWIWMTGGAVSISLIAVLGLLLMIAWRGLSYFWPAEIYQWEMQDQQGAKYTLIGEIYDTEQVPTEQLLSAGHVFKEAPGDTVTRYLVKTGNREFVGLDFRWILATDIISRSLPEDIAVIERSKNGDFYGYPLAVIENDKRLDFENVEASFESHIERSVELNDKAVEIQKGEIGSINYAIEKLRLQERGYELDGELTPVVKADLAQKRAILQAQYQTVEKEFFGLRKQAGRDSVIIKDMRDVEVTLKLDSILDVTYSNRLGLLDKLGHWFVGVGRFVSDDPREANTEGGVFPAIFGTVFMVMLMAVIVTPFGVVAAVYLHEYAKKGPVTKMIRIAVINLAGVPSIVYGVFGLGFFVYMFGGSIDQLFFPEALPAPTFGSPGVLWSALTLAILTLPVVIVSTEEGLSRIPSSVRQASLALGATKAETLWRIVLPMASPAIMTGLILAVARAAGEVAPLMLVGVVKLAPTLPIDVNFPFVHLERKFMHLGFHIYDVGFQSPNVEAARPLVYATSFLLVTVIVSLNLTAIAVRNHLREKYRSLEH
>NC_014012.1|WP_013052326.1|3463612_3465868_-|ABC-transporter-permease-subunit
MDTQVRQPDSKAHNLLMGRGSSSRAIKDKLTEIGVTIGGAMVFVALLLIFFYLLYVIKPIFDDAEVSAVSSVEFNDSAPALIVGSDEQNEIMYRVSQTGRVDFYDVSSSKLIKTEQVVFPEGSQVVSSSASVPSEQRFAFGLDNGQVIIAGIEFGVTYPNNKRLITPNLRFPNGRAPMTVDDRGQSINHLAFDYSSDMMTFAYQDDDQVWRLSRLEGEENMMTEEVEWSSYTGIIKDAPVDVEQQLMTPNQRQLLLSSGNKLFIYDIRDAEAVSLKQVLELGRTGVKVTNVSLLAGASSLLVSYDSGLVQQYFQVNGEQGRKYQEIRDFRNDEGIKSVASEFYRKSFVTISDNGQLSLLYTTSQRKLFSADFNLKNPGTLGFSPRSNALVIEADNKLHMFSVSNTHPEVSWSAMWSKVWYEDYPEPKYVWQSTSGSDDFEAKLSLMPLAFGTMKAAFYAMLFATPLAIAGAIYTAYFMTPKVRSVVKPTIEIMEALPTVILGFLAGLWLAPLIEDHLPGILVLLILLPVSILTSAFIWHNLPDKAKQYLPEAYQELMLIPVILFVGWFSFAISPTLEVAFFDGDSRLFITNELGITFDQRNALVVGIAMGFAVIPTIFSIAEDAVFSVPRHLSNGSLALGATTWQTLTRVVLLTASPGIFSAIMMGVGRAVGETMIVLMATGNTAIMEWSVFQGMRTLAANIAVEVPESAIGSSHYRVLFLAAFVLFIFTFVFNTIAEVVRQRLRERYSSL
>NC_014012.1|WP_013052327.1|3466037_3466538_+|amino-acid-binding-protein
MLRYLVTLQVADKKGLVEQIAHAVSRHGGNWLDSELRHIDGIFAAILLLEVPSSNWDILVENLECIEGLSLTYAKTSKQPNKLQHLSFSLVAYDRPGLVHEISNKISALGINIEHFSSRYETACHTGVALFRANFDLGMKNPEQEEQLCEALYAMGDDVVLDKINR
>NC_014012.1|WP_041419976.1|3466791_3467607_+|DUF2797-domain-containing-protein
MLGTIKKMRATLDDNQQVQYQLPIGDELLDMNPLIGTSVTLTHTGKICCSNCGKRTKKSYSQGHCFVCMRKLASCDLCIMKPETCHFAQGTCREPEWGEANCFVPHYVYLSNTSGLKVGITRHTQLPTRWIDQGATQGLAILKVSTRQISGLVEVELAKMIADKTNWRTMLKGNAQDIDLKAKAAELLPEVENKIHEICMAHGDYAIEKLDEEIQSIRFPVTEFPIKISSHNFDKDPVVSGILLGIKGQYLIFDTGVINMRKFTSYEISVG
>NC_014012.1|WP_013052329.1|3467670_3468075_-|cupin-domain-containing-protein
MLKVLFAASMFASLTAGAATSKDLIKSSESWDGNKLPAYSLTQPEVTIKEIVILPGEELPWHQHPVINAGILLSGELMVYTRDGKQKNLKAGDTLIELVNTSHYGKNISSESAKIVVFYLGEQGDKATVIDKQQ
>NC_014012.1|WP_041419977.1|3468229_3470383_+|TonB-dependent-receptor
MSFSLSQTAIATRCALLCLALPSLSVLADDNARSPADSSMERMIITGSRSVERIDEVPSSVTLIDKKMLKQDMLISSELQNILAFRVPGMAPSSGTSSNSGQTLRGRKALIMIDGVPQSTPLRNGQLGIRSIDAGAIERIEVIKGATSIYGNGASGGIINYITKKASSDDKARIQLGASSKFSAVKFEDTPGYRFDASIDGTIDKFSYVLTGAMEETGLQRDSQGDVIGLKYGLSESKSKNLFTKLGYAFDEEKYLQLTYNYYDAQQKTDYVDVVGSVNSGVKTYAIKDTSGAPKLGVPQGPRGNHNLMLKYVDEEIFSNTQLTLDGYAQVIENMFFYSTRLSNPSAGYAGGQSLIKSDKKGIRVNFNTQLDWDNVEVSFIYGLDALNDVSSQPLDDGRIWVPEMDMTNLAAYLQTKIVIDGDWIIKAGVRQDSVDLSVDDYQTLKVCKSADTCSVPMDVKGGDIDYDTTTFNVGVRYNMNDYFSPFISFSQGSDISDLGRLLRTATVDDISLIRTEASIVDNYEVGVSGQVADLTYEFAAYRSNSELGTGSKYIVETGVYMPVREPQKIWGYEAQLSYQIQENLTSSVSYSWIEGKNTETDTYLDGKTISAPKFTATLDWQPIEEVRIGVNYLYVGDRKRFEPVDGKYVGTLGPVSSYNLVNLSSSYQIDNWQLSLGIENLLNQDYYSARSQAYTYSGYNTKGLGTTVNLGVKTSF
>NC_014012.1|WP_013052331.1|3470880_3471810_+|triacylglycerol-lipase
MNRWIYTLIILLLSLSSSFNATASTSTSATKYPIVLVHGLFGFDDIWGIDYFYKIPQTLQQQGAQVFVANVSPANSSEVRGEQLRNYVQAVLAQTGADKVNLIGHSHGSPTIRYVASVSPEMVASVTSIGGVNWGSNVADFVRGAIPADSAIEWLAQQGFNSLAAIIAGISGNSGLPTDTIAAMESLTTSGSVAFNQRYPEGIPAQFCGQGSALADNGVYYFSWSGASQLTHVFDVSDYPLSLTGLLFNEPNDGLVSSCSSHLGLVIKDNYKMNHLDEVNQTFGLVSWFDTNPVTLYRQHLNRLAQLGL
>NC_014012.1|WP_013052332.1|3471812_3472787_+|lipase-chaperone
MNNRTNPSQRSTKLIGILGLISLILLSLGLVLYLASTREDPSRPAELVSKDQRLYPLASSQKKYPQAPLSSQVFSQPLRLELALKWKFDDIILEYQQHQTAIETQVIKLAHSLKLDSTNLAYLLVLFGRYRDYQQALMEIKKLSPSIDEDMQMSQSLRFIEQVHDSQFQFFSEEEIDAFFAQDNAYDRQAIARAAIRQDTSLSPAQKQQLLVHHLSQLDESEQEALLPSFAAQKIAAVLNDKQAQPQQMPPEIAARVDKVKMAQEEWQARVTSYLKVQQQIRKEHADAQEQEIKIAVYLKQNFSSTEIKRLQVFLRNPSLYHAS
>NC_014012.1|WP_013052333.1|3472845_3473274_-|hypothetical-protein
MKFSITRILVLALALISFQGLAAAEWVKIADKTVDYKTETDTVTPQFREKNVTHIKLKCTQGSVNLHKLVLNMSDGTSKTVDNLGVLTKGLASRSISVPKGDIKLESIDFTYDSVGSQTMALAGLSKKGKLDIMGKKPAQKD

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Crispr_ID: NC_014012_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_10

4004896-4004990

Orphan

Consensus_repeat	Method
CTAAGAAATATAAGAAAGCAGAAAGGTAAATAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014012_10

>merge|NC_014012|10|4004896-4004990|CRISPRCasFinder
CTAAGAAATATAAGAAAGCAGAAAGGTAAATAAGGCTTCGAGCAGTGAGGCTTAGGAAAAGACTAAGAAATATAAGAAAGCAGAAAGGTAAATAA

>NC_014012|10|9|4004896-4004990|CRISPRCasFinder
CTAAGAAATATAAGAAAGCAGAAAGGTAAATAA	GGCTTCGAGCAGTGAGGCTTAGGAAAAGA
CTAAGAAATATAAGAAAGCAGAAAGGTAAATAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_013052813.1\|4015496_4017095_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|168170
NC_014012.1\|WP_041420439.1\|3997298_3997874_-\|UPF0149-family-protein	unknown	unknown	gnl\|CDD\|234976
NC_014012.1\|WP_157608719.1\|4008947_4011524_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_014012.1\|WP_013052804.1\|4001137_4001644_+\|copper-resistance-protein-NlpE-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377235
NC_014012.1\|WP_013052806.1\|4005271_4005940_-\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NC_014012.1\|WP_013052796.1\|3992994_3994089_-\|glycine-cleavage-system-aminomethyltransferase-GcvT	unknown	unknown	gnl\|CDD\|234742
NC_014012.1\|WP_157608885.1\|4001752_4004302_-\|collagenase	unknown	unknown	gnl\|CDD\|366791
NC_014012.1\|WP_013052800.1\|3998487_3998796_+\|cell-division-protein-ZapA	unknown	unknown	gnl\|CDD\|182874
NC_014012.1\|WP_013052807.1\|4006077_4006656_+\|type-II-secretion-system-protein	unknown	unknown	gnl\|CDD\|225076
NC_014012.1\|WP_041420049.1\|4013703_4015200_+\|cytochrome-c-oxidase-accessory-protein-CcoG	unknown	unknown	gnl\|CDD\|274278
NC_014012.1\|WP_013052808.1\|4006837_4007173_+\|DUF3144-domain-containing-protein	unknown	unknown	gnl\|CDD\|378643
NC_014012.1\|WP_013052802.1\|4000503_4000839_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_041420050.1\|4017263_4018316_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|378820
NC_014012.1\|WP_013052801.1\|3999633_4000245_+\|5-formyltetrahydrofolate-cyclo-ligase	unknown	unknown	gnl\|CDD\|182385
NC_014012.1\|WP_013052809.1\|4007351_4007966_-\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NC_014012.1\|WP_013052795.1\|3992567_3992957_-\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NC_014012.1\|WP_041420046.1\|3994532_3995759_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|236139
NC_014012.1\|WP_083779914.1\|3995937_3997224_-\|2-octaprenyl-6-methoxyphenyl-hydroxylase	unknown	unknown	gnl\|CDD\|273911
NC_014012.1\|WP_013052811.1\|4011991_4013461_+\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_014012.1\|WP_041420051.1\|4018417_4018615_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_013052813.1\|4015496_4017095_+\|AMP-binding-protein	gnl\|CDD\|168170	PRK05677, PRK05677, long-chain-fatty-acid--CoA ligase; Validated.	0
NC_014012.1\|WP_041420439.1\|3997298_3997874_-\|UPF0149-family-protein	gnl\|CDD\|234976	PRK01736, PRK01736, hypothetical protein; Reviewed.	6.09814e-44
NC_014012.1\|WP_157608719.1\|4008947_4011524_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	3.17667e-49
NC_014012.1\|WP_013052804.1\|4001137_4001644_+\|copper-resistance-protein-NlpE-N-terminal-domain-containing-protein	gnl\|CDD\|377235	pfam04170, NlpE, NlpE N-terminal domain. This family represents a bacterial outer membrane lipoprotein that is necessary for signalling by the Cpx pathway. This pathway responds to cell envelope disturbances and increases the expression of periplasmic protein folding and degradation factors. While the molecular function of the NlpE protein is unknown, it may be involved in detecting bacterial adhesion to abiotic surfaces. In Escherichia coli and Salmonella typhi, NlpE is also known to confer copper tolerance in copper-sensitive strains of Escherichia coli, and may be involved in copper efflux and delivery of copper to copper-dependent enzymes.	3.91904e-37
NC_014012.1\|WP_013052806.1\|4005271_4005940_-\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	1.34106e-139
NC_014012.1\|WP_013052796.1\|3992994_3994089_-\|glycine-cleavage-system-aminomethyltransferase-GcvT	gnl\|CDD\|234742	PRK00389, gcvT, glycine cleavage system aminomethyltransferase GcvT.	0
NC_014012.1\|WP_157608885.1\|4001752_4004302_-\|collagenase	gnl\|CDD\|366791	pfam01752, Peptidase_M9, Collagenase. This family of enzymes break down collagens.	1.68639e-113
NC_014012.1\|WP_013052800.1\|3998487_3998796_+\|cell-division-protein-ZapA	gnl\|CDD\|182874	PRK10972, PRK10972, cell division protein ZapA.	1.21703e-20
NC_014012.1\|WP_013052807.1\|4006077_4006656_+\|type-II-secretion-system-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	1.1129e-09
NC_014012.1\|WP_041420049.1\|4013703_4015200_+\|cytochrome-c-oxidase-accessory-protein-CcoG	gnl\|CDD\|274278	TIGR02745, iron-sulfur_cluster-binding_protein, cytochrome c oxidase accessory protein FixG. Member of this ferredoxin-like protein family are found exclusively in species with an operon encoding the cbb3 type of cytochrome c oxidase (cco-cbb3), and near the cco-cbb3 operon in about half the cases. The cco-cbb3 is found in a variety of proteobacteria and almost nowhere else, and is associated with oxygen use under microaerobic conditions. Some (but not all) of these proteobacteria are also nitrogen-fixing, hence the gene symbol fixG. FixG was shown essential for functional cco-cbb3 expression in Bradyrhizobium japonicum.	0
NC_014012.1\|WP_013052808.1\|4006837_4007173_+\|DUF3144-domain-containing-protein	gnl\|CDD\|378643	pfam11342, DUF3144, Protein of unknown function (DUF3144). This family of proteins with unknown function appears to be restricted to Proteobacteria.	8.91766e-25
NC_014012.1\|WP_041420050.1\|4017263_4018316_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	8.67942e-19
NC_014012.1\|WP_013052801.1\|3999633_4000245_+\|5-formyltetrahydrofolate-cyclo-ligase	gnl\|CDD\|182385	PRK10333, PRK10333, 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional.	6.67144e-76
NC_014012.1\|WP_013052809.1\|4007351_4007966_-\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	5.56392e-30
NC_014012.1\|WP_013052795.1\|3992567_3992957_-\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	3.18378e-73
NC_014012.1\|WP_041420046.1\|3994532_3995759_-\|FAD-dependent-monooxygenase	gnl\|CDD\|236139	PRK08013, PRK08013, oxidoreductase; Provisional.	0
NC_014012.1\|WP_083779914.1\|3995937_3997224_-\|2-octaprenyl-6-methoxyphenyl-hydroxylase	gnl\|CDD\|273911	TIGR01984, 2-polyprenyl-6-methoxyphenol_hydroxylase, 2-polyprenyl-6-methoxyphenol 4-hydroxylase. This model represents the FAD-dependent monoxygenase responsible for the second hydroxylation step in the aerobic ubiquinone bioynthetic pathway. The scope of this model is limited to the proteobacteria. This family is closely related to the UbiF hydroxylase which catalyzes the final hydroxylation step. The enzyme has also been named VisB due to a mutant VISible light sensitive phenotype. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	5.99388e-170
NC_014012.1\|WP_013052811.1\|4011991_4013461_+\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	4.70548e-136

>NC_014012.1|WP_157608885.1|4001752_4004302_-|collagenase
MSLSQIKQGKINKSVIQGATGMVGPEGNQGPAAAACVEYAEFASLTGQDLFDFVRTTDFNCISDLYRENDATAVAAYQASNVADVANLAKAMAASYDSTTGSEMLNLFYFLRGAFYIEYYNDDLTYSDDTASHAVRDLLVEYTKNPNFADTSSSQGNTLAEFFIAWDSSDSYYEGVEAISNYLEVFSPEHLANSDHRYALTKALTTLYYGSWDATYTGAAESHTSLINGLLKIATSEYIYNSDYSYESSDAFHEFGRFYEYQEYWGLSAALKTRLNEGVVEYMNNFERMSSEWADAAGYLDWYNPGECEQFGICGWAEELEATILSINYSCSDTINIRAQQLTTDELQASCDLMGGEEILFHEVLDTEYQPVADDNNTNLEVNIFDSYSDYNQYAGIIFGIGTDNGGMYLEGTPSDVDNQARFIAHEATWTDEILVWNLRHEYVHYLDGRYNQYGAFNYFDIDTGKSVWWSEGLAEYISHQNRYDEAVETGRSQSFTLSEILSNTYNSGSERVYRWGYLGVRFLFENHRDDVDQLLELARGGDASGWLGYIDNEIGTQYDAEWNTWLSTVTSNDEPLAGCEGDECLPPPCEETNTCPPVPCEETDTCPVEPCEDTNSCPPEECTDEACDPANSNLVDGVAKIGVSGGTAYYYIWVPEGTENIQFSSTGGTGDANLYAKAGAWATSTDYDQASENAGNDESVLVTEIVGGDYYYVTLDSSDAFDGLNLLAEFNVDAEPVDPVEPIEVTELQSGVRVKKLASDDALYFKIFVPGDMKKVKFIMSRGKGEADMYVRFGAIPTMDEYDFTDTKDLGRERIIVKRPEGEDFYYIMLKARDGDFSKVNLKAKFKQ
>NC_014012.1|WP_013052804.1|4001137_4001644_+|copper-resistance-protein-NlpE-N-terminal-domain-containing-protein
MMKLPIITVSLLALCITACSEQEIKTSESKPQIQSQPQAQLEQVKESQPQGDTSRTSLDWQATYSGVIPCASCEGIKTVLTLKQDNTYVLESIYLGTSAPGEKPNVFTEAGPFQWNDAGNTISLMGDTSELAKPKQYRVGESQLMMLDRQGNTITGSLADNYRLEKKG
>NC_014012.1|WP_013052802.1|4000503_4000839_+|hypothetical-protein
MKLQLIAVALLALGATACSQQETQTPNSEQEVQVQVEQVEAQVSDKVEQVAEQVNDKVEQVAVEVSDKVEQAKVELNDQVEQAKVELNDKVEQAKVELNDKAAQLKEQAIK
>NC_014012.1|WP_013052801.1|3999633_4000245_+|5-formyltetrahydrofolate-cyclo-ligase
MPFTPSEIAQTERQSIRTQIRQARRALTAEQQSTYATQAAKLMLTQPKILEAKHLALYLSNDGELDTAPLIQALWALGIKLYLPRLHPFSQGNLIFMAYTPETEMLKNSYGIAEPKLDIRGLIPSEKLDVIITPLVAFDTQGNRMGMGGGYYDRTLASHRSQDKPYPVGYAHDCQQLDSLPCEHWDVPLPLLITPTQVLKFNI
>NC_014012.1|WP_013052800.1|3998487_3998796_+|cell-division-protein-ZapA
MSSHAIDISLLGRTYSINCPKGQERALQHVAQKLEVQLNSLKTRTHNLSREEVAIMAALNTGYELLEEQQKNQDYNKQMDEKIGLLQSTIENALVERSIKED
>NC_014012.1|WP_041420439.1|3997298_3997874_-|UPF0149-family-protein
MATPPSLRIDNLLAALDTAEIGQTPVEVHGALVGIICGGVELSKDAWIKPLLELMNDGQPLPEQLHLLIEELYQDTLTRVSDIEFGFSPMLPEEEEPLTKRVEALSLWVQSFLTGLAMVQPKIDKASADVQEVIKDLADIAQVEFDVAEDEESESAYMELMEFAKMAALLCYSEFGPDLTDPNQKEANVFH
>NC_014012.1|WP_083779914.1|3995937_3997224_-|2-octaprenyl-6-methoxyphenyl-hydroxylase
MTADIEENINTTSPHTLQPQEISRVDVAIVGGAMAGATLALGLKKLSQELNRPLKIALIEAHKPGSEHPGFDARSIAIAHGSIFELKRLGLWSKLAHLGTPIENIHISDRGHFGMTELNAEDFHLQNLGQVVELERVGQVLFNLLQESDIQLHCPGSLAHVEAQTDCQLLTLNDGTQIKTSLLVAADGVNSRVRQAFGLPLEQVDFEQVALVANIETDKPHENWAFERFTNTGPLAVLPMAPLKGNPRVSLVWALTPSDAKRLQSIAKDEFLAELQAAFGFRAGRFTQVGERLSYPLLLSHMPRPIYHRTVFIGNAAQTLHPIAGQGFNLGLRDLVSLLDVIKQALLDEGSSEDMLDLGSASLTHAYLHSREKDRNSTMTNIEFLVRSFSNDHWPLVIGRSLGLRLLSWMPPLKVPVARTAMGWKSVS
>NC_014012.1|WP_041420046.1|3994532_3995759_-|FAD-dependent-monooxygenase
MHTNSSAMQTYDVAIIGGGMVGLATAIGLAMDELRVVVIDAGEAQAVSGEARLRVSAINKASQRLLQNLGAWSYLDDERVSPYQKMEVWDKDSLGKIGFDAHSLSEEYLGSIIENDNIRFALSKRAAEFDEITYLQNHKLDRIAFGEREAWLTLDNGDNISAALVIGADGANSWVREQCKIPMTFWDYGHHAVVASIRTELPHQATARQVFLKDGPLAFLPLYENNLCSIVWSVPPAKAQQLLAASKQEFERTLTAEFDGRMGMCQLECEPQAFPLRMRYARHFARHRMLLAGDAAHTIHPLAGQGVNLGFLDAAAIIETITELKLDGKDIGDYANLRALERWRKADALEMIAAMEGFKRLFEGSNPLKKAIRDFGLNLVDNLSPVKTLFIQQAMGNKNSLPKLCKQD
>NC_014012.1|WP_013052796.1|3992994_3994089_-|glycine-cleavage-system-aminomethyltransferase-GcvT
MANKTVLFNKHLESDAKMVDFHGWDMPLNYGSQIEEHHAVRQDAGMFDVSHMTVVDVTGTDACVFLRKLLANDVAKLKIPGKALYGGMLDHSAGVIDDLITYYLTDTHYRIVVNSATREKDLAWIAQEVKGFDVVISERPELAMIAVQGPNAKAKAASVFNADQNAAVEGMKPFFGVQSGSLFIATTGYTGETGYEIIVPEAEAEVLWQALLEAGVKPCGLGARDTLRLEAGMNLYGLDMDESVNPLAANMGWTIAWEPEDRNFNGREALAAIKAAGTEKMVGLIMEAKGVIRPGMSIFFTDGEGNEQQGIITSGTFSPTLGYSIAMARVPRSIGDTAEVEMRKKRVTVKVIKPSFVRNGKQAF
>NC_014012.1|WP_013052795.1|3992567_3992957_-|glycine-cleavage-system-protein-GcvH
MSNIPTELRYASSHEWIRKEEDGSYTVGISEHAQELLGDMVFIELPDVGDTVTAGEDCAVAESVKAASDIYAPISGEVLAINEALEDSPELVNSDAFGDGWFFRVMPSDTAEIENLLNAEGYQAVIDEE
>NC_014012.1|WP_013052806.1|4005271_4005940_-|uracil-DNA-glycosylase
MTVHSNWNTFIEAEKSLVYYQKLQGFVQSERDSGKAIYPPQEEVFTAFEKTPLDKVRVVIIGQDPYHGPNQAHGLCFSVKHGVKTPPSLVNIYKELVTDITGFKTPDHGHLSSWAEQGVLMLNTVLTVEQGLAHSHGKSGWETFTTNALKLLNEQETPLVFIFWGAHAIKKGKVITSEHHHILSGPHPSPLSAYRGFFGCKHFSKTNALLASLGTKQIDWQV
>NC_014012.1|WP_013052807.1|4006077_4006656_+|type-II-secretion-system-protein
MHHPSRKSHIRAISLNNRAAGFTLIELVVVIIILGILSVVALPKFINLSLDAHVSTVKGTGGAFKSGINLARSVWAVRVGSGPADDLPTFGDTESGEMDFNDNGWPAQHWGTPDSNDDSPKLDNTDDCISVWETIFAGNEPSVSNSISNETDYVATYNFDNSCTYTYSANTNLSITYDSLDGSLVIDSDPQN
>NC_014012.1|WP_013052808.1|4006837_4007173_+|DUF3144-domain-containing-protein
MSEAEKETTIFQLADQFIALANEINAKEQDVSKVGTALRFAASRFNAFEAALKSADLAAEKANALEWFTKEYKEMLKDNLDDHINNPPLSKELEAKEQEPAKDDAVQVFTK
>NC_014012.1|WP_013052809.1|4007351_4007966_-|LysE-family-translocator
MSFTAWLSLVAICCLGAMSPGPSLAMVVRHTLGGGRGKGIICAWAHSIGIGIYALVTLLGLAVVLKKAPMVFNGIAITGALYLAWMGVQALRSKGGMSEKLVAGKSTDSFTAARDGLAISLFNPKILLFFLALFSQFVMAADSLWGKSLIVFTPLIIDGLWFTIIAMLLSHKSVLPKLREKAALIDKLSGVVLILLAVRVLVTI
>NC_014012.1|WP_157608719.1|4008947_4011524_-|TonB-dependent-receptor
MSNNNKFGISSLSLAISIALAGSFASTQALAAEDQNISESVERIAVIGSRSAPRSVGESPVPIDIIDSEDLRKNGSTDMIDMLVASVPSFNSRAQPISDAATLVRPVNLRGLPSDSTLVLVNGKRRHRASVIAFQGGGINDGAQGPDISVIPGVALKQVEVLRDGASAQYGSDAIAGVMNFVLKDDAEGGSITVSQGEYYKGDGATTTIDGNIGLPLTDSGFVNISAQYKTADATSRSVQRQDAANLIAQGNMDVNDPAQIWGNPEIKDDYTVFVNTGFDINDSAQLYAFGNLSSRDVVGGFYYRNPHNRGNVYSVDDGETLLVGALNGDQSSCNAVPIPKVTDANGNILDGNVLTSQPYLDMLADPNCFSMNQIRPGGYTPQFAGTVKDSSFFAGIKGDIGEWSYDASAGMGNNKSTFSLRNSLNPSLGLDTPTDFETGAYEQSETTVNIDFSRSITIGALEDLSFATGFEWREESFEITQGEESSWIAGPYADQGFNIGSHGFKGFGPESASKNSRNNIGIYADVEGYLTDDWLLGVALRYEDFSTFGDTLNYKISTQYSATDYLSFRASHSTGFRAPTVGQENVVNTQTSIVNGDLIQTFIAPPTNPLAAFYGGKVLNPEESVSYAFGTVFEYENFFLTLDYYNIEVTGRLAQSSQIAVEEEDYDELRAAGIEHPELISAVTFYTNDFDTTTQGIDIVGSYETEFLSGDANLSLAYGWNDTSVDKYDPDTTDEGKVRRLEDGIPAHRGTLTWGQSWAKLSTTLRANYFGEYYATHADDTTEWGSEVADAAVTFDLEISYAVLESLTFSVGANNIFDQEAQKLKDGTLGALGGVYYESGPFDYNGGFYYGRVNYIF
>NC_014012.1|WP_013052811.1|4011991_4013461_+|sigma-54-interacting-transcriptional-regulator
MTKYGDEIPVSTQLSIDSHADFLPENKLLLNAVGEGIYGFDLKGNAVFINPAAERMTGWKNEELLGRNIHNSHHHSHADGSHYPQQDCPIYNTLHDGIARETSQDVFWRKDGSSFPVHYTSTPVYKDGELIGVVAIFRDISIQKQTEDSLRQALEQVQALSEKLTNENHYLLAELADRTGDVGISGESQVIQQMIRQIKLVANTNSTVLIYGENGTGKELVARNLHRLSDRSNKPMVSVNCAAFSTSLLESELFGHEKGAFTGAFSRRKGRFELANNGTLFLDEVAELSMEAQSKLLRVIQEQEFERVGSSETIKVNIRLVAASHHDLLKRVELGLFRMDLYYRLNVFPIKVPALRERPDDIPQLIRHIVTELNRKLGKKIKGVSKQGLKNLMAYSWPGNVRELQNLLERFSILSHGPILHIPKITPQTTENPVKGEKTLAQVEAEHIKQTLQRLSWRISGPKGAAAVLGLPPSTLRSRMKKLNVIRGV
>NC_014012.1|WP_041420049.1|4013703_4015200_+|cytochrome-c-oxidase-accessory-protein-CcoG
MKNNINSSSINPISIKAGALVQLSPALAKTSQTIAIKQIPASSKPINNKIHIREQKGYFQRLRTSLNSIIIAIFFLLPLIQYQGRQAVLFDLNKQEFYFFGTTLWPQDFTLLAWIFITAAFLLFFITAFLGRVWCGYLCPQTAWTFIFVWIEARIEGSHNKRRILDKSPWNRDKIIKRSGKHLLWGLIALLTGCGFIAYFVPATSLYPQIFSLSASPMLTAWVWFFAICTYINAAWMREMVCLHLCPYARFQSAMFDANTITVAYDPSRGESRGPRKRKQATDLGDCIDCNLCVDVCPTGIDIRNGLQYECINCGACVDACDQTMDKFGYARNLIGYRSENHLKGQRNKPLTSLKFLGYGIAAMVMFSVICIDIYLKKDIQLNVLRDRQSLYRETLDDKIENSYTLKVRNKTQSEKYYRLSVSGNRHYSLQESIELKVKAGEQITYPLTVYSQVNEAIDKATPGAYPMRAGMAKIVFKLIDTQDPNNQISQDSNFFTP
>NC_014012.1|WP_013052813.1|4015496_4017095_+|AMP-binding-protein
MAYDSDSTLDLTQYSSLIDLIETASEKYADKTAYACLGHHASFSEIERDSRYFAAYLQSISGLNPGDRIAIQLPNIIQYVIAAYGAIRAGMVLVNTNPLYTERELTHQYNDSGAKVLVVLSDLLPKLENVVANTGIDTVISTHAADLLAPQTQAQVSFKTHKFLDVLAQGESLPFKRFSTKLDTLAALQYTGGTTGLSKGAMLSHSNLIANAMQIKSRLGDKLVQGEEIFVAPLPVYHIYAFMINLVLYFERGCCSVLVPNPRDIGSLIKTLSDYKFTGFAGLNTLFVGLCHQVEFKALDFSHLKVTISGGTALTQAAAGMWKETTDCTISEGYGLSETSPVVSLNAPGLEQLGTIGKPVIGTQVKILDNDGNEVPQGETGELALKGPQVMSAYWNKPEETAEVMTDDGYFKTGDIALATQDGLHQIVDRKKDMIIVSGFNVYPNEVENVLASHETVLECAVIGVTDERCGEAVKAVIVLTDPNCDPEAAKEAIISYCREQLTAYKIPKQIEFMSALPKSTVGKILRRELRK
>NC_014012.1|WP_041420050.1|4017263_4018316_-|alpha/beta-fold-hydrolase
MSPILKRIFISVSISILIYLGIAFGLVYFGGPDAVEAKAVMNKAGSIKQGALVDQGIDFSEMRLDYSGMPALQSYTARDGAQLDYRYYASDSDKVLILLHGSGWHSQQFFPLAKYISEQGLAQVVTPDLRGHGVSPSRRGDIDYIGQFEDDLADLIVQLQQDAELKGLQSSTIIMGGHSSGGGLAIRFAGGAYGDLADAYLLLAPFIYHNAPTTRPNAGGWAKPYTARIIGLSMLNSIGIHGLDHLNCIEFNMPEAVRNGTETLAYSFRLNSSFAPRNYRKDISAISQPLLLLAGSADETMFADKYQALISSLLPNNNKAEVKLLPGLSHMAIVVSPDVRPDIKQWLRAL
>NC_014012.1|WP_041420051.1|4018417_4018615_+|hypothetical-protein
MKLDYIFGFASGFVGIWLINESRTFMVIYRLPGGDVHMLLRAAASTSLWALPKHPCFGSSQLHLH

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Crispr_ID: NC_014012_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_11

4128891-4129008

Orphan

Consensus_repeat	Method
AGGAACATAATCGGATGGCAGATATGAAGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014012_11

>merge|NC_014012|11|4128891-4129008|CRISPRCasFinder
AGGAACATAATCGGATGGCAGATATGAAGATTGGCGGTGGTAATATCTCGGTCAACCAGCAGCTCAGAGTGACATATACCGACTAGGAGGAACATAATCGGATGGCAGAGATGAAGAT

>NC_014012|11|10|4128891-4129008|CRISPRCasFinder
AGGAACATAATCGGATGGCAGATATGAAGAT	TGGCGGTGGTAATATCTCGGTCAACCAGCAGCTCAGAGTGACATATACCGACTAGG
AGGAACATAATCGGATGGCAGAGATGAAGAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_041420448.1\|4124173_4125097_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_014012.1\|WP_013052913.1\|4129438_4130785_+\|Na+/H+-antiporter-NhaC-family-protein	unknown	unknown	gnl\|CDD\|224671
NC_014012.1\|WP_013052920.1\|4138112_4139312_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|185086
NC_014012.1\|WP_013052904.1\|4119879_4121085_-\|potassium/proton-antiporter	unknown	unknown	gnl\|CDD\|235410
NC_014012.1\|WP_083779918.1\|4118280_4118886_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|183400
NC_014012.1\|WP_013052910.1\|4126536_4127352_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223904
NC_014012.1\|WP_013052919.1\|4135709_4137866_-\|S46-family-peptidase	unknown	unknown	gnl\|CDD\|371067
NC_014012.1\|WP_013052916.1\|4133647_4134265_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_041420063.1\|4125712_4126000_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NC_014012.1\|WP_013052917.1\|4134373_4134928_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013052906.1\|4122522_4123980_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143421
NC_014012.1\|WP_013052911.1\|4127559_4128084_-\|DUF3087-domain-containing-protein	unknown	unknown	gnl\|CDD\|378624
NC_014012.1\|WP_013052915.1\|4132108_4132861_+\|pseudouridine-synthase	unknown	unknown	gnl\|CDD\|211328
NC_014012.1\|WP_013052924.1\|4142874_4143123_-\|YgjV-family-protein	unknown	unknown	unknown
NC_014012.1\|WP_013052905.1\|4121454_4122243_-\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|234599
NC_014012.1\|WP_013052912.1\|4128235_4128571_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013052923.1\|4140748_4142215_-\|catalase	unknown	unknown	gnl\|CDD\|163712
NC_014012.1\|WP_013052909.1\|4126141_4126411_+\|ribbon-helix-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|372613
NC_014012.1\|WP_013052914.1\|4131356_4131986_+\|DUF998-domain-containing-protein	unknown	unknown	unknown
NC_014012.1\|WP_013052922.1\|4139990_4140566_+\|TMEM165/GDT1-family-protein	unknown	unknown	gnl\|CDD\|225030

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_041420448.1\|4124173_4125097_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.94619e-35
NC_014012.1\|WP_013052913.1\|4129438_4130785_+\|Na+/H+-antiporter-NhaC-family-protein	gnl\|CDD\|224671	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion].	4.60428e-72
NC_014012.1\|WP_013052920.1\|4138112_4139312_-\|amino-acid-permease	gnl\|CDD\|185086	PRK15132, PRK15132, tyrosine transporter TyrP; Provisional.	2.64433e-95
NC_014012.1\|WP_013052904.1\|4119879_4121085_-\|potassium/proton-antiporter	gnl\|CDD\|235410	PRK05326, PRK05326, potassium/proton antiporter.	1.07018e-111
NC_014012.1\|WP_083779918.1\|4118280_4118886_-\|hypothetical-protein	gnl\|CDD\|183400	PRK12282, PRK12282, tryptophanyl-tRNA synthetase II; Reviewed.	3.38538e-122
NC_014012.1\|WP_013052910.1\|4126536_4127352_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223904	COG0834, HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms].	3.52059e-12
NC_014012.1\|WP_013052922.1\|4139990_4140566_+\|TMEM165/GDT1-family-protein	gnl\|CDD\|225030	COG2119, COG2119, Predicted membrane protein [Function unknown].	4.90873e-48
NC_014012.1\|WP_041420063.1\|4125712_4126000_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	3.66233e-25
NC_014012.1\|WP_013052906.1\|4122522_4123980_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	gnl\|CDD\|143421	cd07103, ALDH_F5_SSADH_GabD, Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like. Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.	0
NC_014012.1\|WP_013052911.1\|4127559_4128084_-\|DUF3087-domain-containing-protein	gnl\|CDD\|378624	pfam11286, DUF3087, Protein of unknown function (DUF3087). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	2.25188e-79
NC_014012.1\|WP_013052915.1\|4132108_4132861_+\|pseudouridine-synthase	gnl\|CDD\|211328	cd02554, PseudoU_synth_RluF, Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RluF makes psi2604 in 23S RNA. psi2604 has only been detected in E. coli. It is absent from other eubacteria despite a precursor U at that site and from eukarya and archea which lack a precursor U at that site.	3.90251e-81
NC_014012.1\|WP_013052905.1\|4121454_4122243_-\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|234599	PRK00052, PRK00052, prolipoprotein diacylglyceryl transferase; Reviewed.	6.17197e-89
NC_014012.1\|WP_013052923.1\|4140748_4142215_-\|catalase	gnl\|CDD\|163712	cd08156, catalase_clade_3, Clade 3 of the heme-binding enzyme catalase. Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes, which is involved in the protection of cells from the toxic effects of peroxides. It catalyzes the conversion of hydrogen peroxide to water and molecular oxygen. Catalases also utilize hydrogen peroxide to oxidize various substrates such as alcohol or phenols. Clade 3 catalases are the most abundant subfamily and are found in all three kingdoms of life; they have a relatively small subunit size of 43 to 75 kDa, and bind a protoheme IX (heme b) group buried deep inside the structure. Clade 3 catalases also bind NADPH as a second redox-active cofactor. They form tetramers, and in eukaryotic cells, catalases are located in peroxisomes.	0
NC_014012.1\|WP_013052909.1\|4126141_4126411_+\|ribbon-helix-helix-domain-containing-protein	gnl\|CDD\|372613	pfam13467, RHH_4, Ribbon-helix-helix domain. This short bacterial protein contains a ribbon-helix-helix domain that is likely to be DNA-binding.	4.6207e-22
NC_014012.1\|WP_013052919.1\|4135709_4137866_-\|S46-family-peptidase	gnl\|CDD\|371067	pfam10459, Peptidase_S46, Peptidase S46. Dipeptidyl-peptidase 7 (DPP-7) is the best characterized member of this family. It is a serine peptidase that is located on the cell surface and is predicted to have two N-terminal transmembrane domains.	0

>NC_014012.1|WP_013052912.1|4128235_4128571_+|hypothetical-protein
MQYQVIAIFTGLILSVTANASEQYICELDNQQRIIEVIYKNPLESVPCQVNYRKKNSSETLWQAKNQAGYCEAKADEFAIKLESLGWRCQHLDQPAADSKDNQASEVQEIK
>NC_014012.1|WP_013052911.1|4127559_4128084_-|DUF3087-domain-containing-protein
MKLQEIDKVVYRRRLNVVTIALVAGLLLLSLAFGSGLIALFGEVNDVSGEATGNFHLNLFGVVMAAILSVVVLMQVKDKPYMTEVYYVWRLKAVHNRIYRRLKKIKAAAATHDIDALAILSFYYQGQKLVYQLDNNTLTLSKLEKDISDLQAVINEHHLTVSAEDFNVELLSKF
>NC_014012.1|WP_013052910.1|4126536_4127352_-|ABC-transporter-substrate-binding-protein
MKKAIMGITMVIILLVGNLFPLQVTADHALNIAIVEYPPYEFTRDTPEGGIEFDGISVKLVEEVFRRIEQPISLQVLPWSRALKLLKEGKIDGLFEVLIRPERLVYADYSRQVLMEEVVMLFVAEDSDIEFDGDLATLGDYHFGMRKDFSYGTVFDNAVETKLLKRVSVDVTSSTLLLKLCTGGIDILIAEKDTIFYVDKEIKALQTSSLKRCKKIKRLVKEVQSTPTYMAFSKKSHLSYVRDQFDVILLQMKQDGSYQQIIGEWKQSNIK
>NC_014012.1|WP_013052909.1|4126141_4126411_+|ribbon-helix-helix-domain-containing-protein
MDNLYFDNPTSHYLPIQKSIRIQGHVTSISLEKLFWDLLDQIAESQGVKRNQFIASLYIEALNHHGDVKNFTSLLRSACVQHILSKENG
>NC_014012.1|WP_041420063.1|4125712_4126000_+|antibiotic-biosynthesis-monooxygenase
MINVLTRFKAQSGKEKALLELLKSLVQPTRNELGCVKYELHQENEKQGHFIFIKSFVDHAAFEKHQNTGHFKRLKKEMPELIAQEPEIIILSRHA
>NC_014012.1|WP_041420448.1|4124173_4125097_+|LysR-family-transcriptional-regulator
MSKSSILPKTVTEYDLRLLRIFRTVVENGGFSASEAELGVTRSTISVHMSNLESRMKLKLCSRGRGGFALTEDGQTVYHACIELFDSLNDFSRLVNGLGEELSGELIILCAEQLDSHMQLKLAEVVKKIHKAQPQLHLVLDNEALKHIEKCLLKEKVHIGLLPSYQQVEGLDYQTIYSEPIYLCCSHSHPFFQLEDDEISNQMLAQTPAIHPGIDIDSEAREQLKRLNLCAKAYQFDTRKTLILSGCYIGYLPLSYIQQELESKQVKIIHSDSTSYQFNLSMVSKHNPRETSKIELLKTIFNEVFTQ
>NC_014012.1|WP_013052906.1|4122522_4123980_-|NAD-dependent-succinate-semialdehyde-dehydrogenase
MQQVNDSGLVKLSSYIDGRWSDSSERFDVINPANDRVVAQVCNAGIAETEAAVVAAKKALPAWSKKSANERAVILRSWFNLMMESQDDLSRILTLEQGKPLAEAKGEIAYGAAFIDWFAEEGKRVYGDIIPSPTGDKRIIVIKQPVGVVAAITPWNFPNAMIARKAAAALAAGCTFVVRPSPSTPLSALAMAELAERAGVPAGVFNVVVGLDSSGMGKVLTQHPDVSKFSFTGSTAVGKILMNQTATSVKKVSMELGGNAPFIVFDDADIYEAVQGALISKYRNAGQTCVCTNRVLVQRSVVQEFTDKFASAVAEIKIGNGLAAGVNLGPMITSEAVDGVHKLVEETVAAGAKIIAGGKRSAAGNNFYEPTILTGVTNDMPLASNEIFGPVTPIISFDTEEEAIKIANDTEYGLAAYFYSRDIGRVWRVAEGLEFGMVGINEGIIANPAAPFGGIKQSGNGREGSKYGLDDYMEIKYICMGGLNS
>NC_014012.1|WP_013052905.1|4121454_4122243_-|prolipoprotein-diacylglyceryl-transferase
MDHFVWNIDPVLISFMGLKVHWYGALFATAIACGFQVMKRIYIKEKLPVESLDNLLMYCVIGIIIGARLAHCIFYDPAYYLSNPLKIFAIWEGGLASHGGGLGAILALYYYRRKMDMPFLFLLDRLAIATAIFGFFVRIANFMNSEILGLPSNVPWAIIFERVDILPRHPAQLYEAFAYLAIFIGLWAVYKYTEMKQKEGAIFGLFLVLVFSARFAIEFVKVKQAAYAEGMTLSAGQWLSVPFLIVGVVLLVLPYLNKKVRA
>NC_014012.1|WP_013052904.1|4119879_4121085_-|potassium/proton-antiporter
MSYEILLLGIALLIAIGILLHHPSKTLGIPSLLIFMGVGLALGNGEFDFVYDNLAVTSMVGAVALNIIVFVGGINTSNESIKLAYREGGVLSTFGVLFTTLILAALLYPLTEWSLVICLLLAAIVSSTDAAAVFSILESKKLKLKEKTDTVLEFESATNDPVALIMVVILTGIALAPEKAISGWEIAQTLLIQLGAGIIIAYLVGRLAVYLLNTIHLEEYGLIPVFVLASFIIAAYGSDLAGGNILIASYVVGVVIGNGIKRGREVNKHFFNSLSWLAQSLMFIILGLQIFPQTLFSVFFLSLIPAALLMFVARPLAVQLCYLPFRKASWRKRLFISSIGLKGATPIVFSLIPAAAGVEGAIELVHVVFFIVLFSILLQGGAIEPLANKLKLNNKANPGKG
>NC_014012.1|WP_083779918.1|4118280_4118886_-|hypothetical-protein
MSQAADITAFNATLVPVGEDQLPMLEQTNEIVRRLNHIAGSAILTECKPLLSKVSRLPSTDGLSKMSKSMGNTIMLSASEREITKAVKSMYTDPGHLRVEDPGKVEGNVVFTYLDAFHPDIDYILRLKEQYRCGGLGDGKTKKILEECLQETLKPIRERRAMFIDDKAQLIDILKRGTEQAQDESNRVLMSVKQAFGLNLF
>NC_014012.1|WP_013052913.1|4129438_4130785_+|Na+/H+-antiporter-NhaC-family-protein
MSPQDKSTQTNGAPTASFIALLPLFLFLSLFIGAGLYFQSQGVDFAFYQLPSVVAILPAIIFALIISKQRLNQSIDTFIAGIGHANIIAMCLIYLLAGAFAAVAKATGGVDATVALGLSLVPSNLLLPGFFVIAAFIATAMGTSMGTIAAVAPIALGVANEAQIELPLMAGAVISGALFGDNLSIISDTTIAATRTQGCEMKDKFRENLIFAIPASIITLIAFTFAGQGQADVAVQEIEFIKVIPYLTILILAVAGLNVFVVLTIGILLAGITGLVTMDYGVIQFGQDIYAGFGNMQEIFILSMLVGGLAALMQQQGGLEFVSKQIEKLIAKFSKAKGGASTRASELGMAGIVALTNTCVANNTVSIVVTGDIAKDLAQKHQVTPKRAASILDTFSCIVQGLIPYGAQALLIASTFSISPLEAVTHAWYCMILALVAISVVIFRKRTS
>NC_014012.1|WP_013052914.1|4131356_4131986_+|DUF998-domain-containing-protein
MILVGACVTSVGISISVWAEYQDIGMQVFFRRSDFLGDYVQSPLAYVFNMSLIIAGTCILLAMYGLYLLKLGDFSHFLSIAGSWVGLSIILIGVFPINYLNEHRLVSTSFLMSTFVLHLFTISTRFNHKEICSRPLFILAIFGFLSASGLIYQLDWSTLDFTPCLHEGGDICWVALNMWLQTNITMLWCVLLALNIRKLAIEQYHAESG
>NC_014012.1|WP_013052915.1|4132108_4132861_+|pseudouridine-synthase
MTQDKPSMRLAKYLAMTGLCSRKAATRYIRDGHITLDGRLANHIDTISLIESPSGLTSLEILKFDGVLIQGVESKQYWMLNKSVGTDCRLLAHDPSSLLHLLPDNPRLYPVGRLDKDSRGQLILTNDGELTQQLMHPDFGHSKTYHVQVDGNFEDSFLIKMAQGVSYRDVTTLPCKMTRLNDNKFEIILTQGLNRQIRRMSQALGYKVVDLKRVNIQSLALGDLKEGEMRQLTALEQALLIESCRPSNEG
>NC_014012.1|WP_013052916.1|4133647_4134265_+|hypothetical-protein
MPTFFQFLELYGGLSAVVIALNVAAYKLYFLNQKVNLEKAKDREISKLKADLDASNLMLEKSLEKIAHVDQSRFDKEFDIYQKVWESLTKLNMEAEQLQYKLKSSDSMEEKDKDILNLFHSIMTTSETIHTSTPFYPKSIHKITTLILSQLQDYIRNVSTIRDDGSEKLLSWTSDHSRVYAKSNYNELEVAIKERLDSLSGVKNV
>NC_014012.1|WP_013052917.1|4134373_4134928_+|hypothetical-protein
MHFEISKEEKTLLLSLNSGISKVKIYKGGSYPSVVSFILKNGKTVTICIKEEYVAHWFEVFPISISEDNLSVSPEIVLDGADFSPEVGLNILSKAEWTVPANAEEKTKMIGETEGAMVQSEGLASEIPSNANNQATLHAGIEINKKSGIPFIVASSISPYTLYVSDCNFYEPFDERIYDRVQVC
>NC_014012.1|WP_013052919.1|4135709_4137866_-|S46-family-peptidase
MNKWLLTVAVAATFGAQADEGMWQPYQLPAMADELKAKGLEIDVKSISKLTEFPMNAVISLGGCTASFVSAKGLAVTNHHCAYGSIQYNSTPEKNLLKDGFLAKSYSEELPATPGSRIYVTEAVTDVTDKVKLGLENKLGHHYYQGVELKEKSLVAECEAEAGYRCQVHSFHGGLEYYLVKQLEIRDVRLVYNPAASVGKYGGDTDNWMWPRHTGDFSFYRGYVSKDGKPADFSKDNVPYEPKSFLKVSAKGVSDGDFVMVAGYPGRTNRYRTANEVENQFEWSYPEGKMLRERIIEIIKDTALEGSDERIKYESLIAGLANYAKNFTSMIEFYGKSTILEDRQGRESDLSNWINKTSKRKAKYGETLAELDSLIAEGQEHQARDTILGYIRYSTMMPTARKLYRLANEKQVDDMAREPGYQERDMTRFKSSMERIDRRYAASVDKALVFDLLKRYAVLPASERIAALDKVFGIGKKLDEKQLSKTLDKMYAKTTLGDMDTRLAWLDKPVADFKASKDPFIQFAVAMYDTDMKAEKKDKELGGKLMKVRPQYMAAIIAYNTEQGKPVYADANSSLRVTVGHVKGYSPQDGLKAVPFTRLEGILAKDTGADPFDAPSKQLELIKQKQYGDFYMKSIDSVPVNFLSTLDTTGGNSGSPTLNGRAELVGLLFDGVYESIIGDWGYDPESNRSIQVDSRYMLWVMKYLDNADNLLAEMDIVY
>NC_014012.1|WP_013052920.1|4138112_4139312_-|amino-acid-permease
MNLKMLGSIAIVAGTAIGGGMLALPLATASLGTLPALLLLVVIWGISIYTSLLMLEINLRTGVGDNVHAITGKILGKFGQLFQGASFMSLLFALTMVYLMGGSSLLESRFEPLGITLDNQVAVLLFTVLFGGIIAVGVGWIDKISRFLFTTMVALLVIVVAFLFPDVNLSVMLSDTASQAISTGELNNLWLAAVPIVFTSFGFHVCIATIVRYMDGDQVSLRKILIIGSTIPLISYILWLMVTLGTLGGGTVYGFEGSLPLLVTALQGLAHSEILKQCIDLFANLALITSFLGVTMSLFDYVAELTRAKNDFAGRAKTWLITFVPPLLCALYYPDGFIQVLGFAAIPLVVMIIFLPIAMALKQRKQNLGGYQVSGGTPALVIAGILGAVIIGSQLSVAL
>NC_014012.1|WP_013052922.1|4139990_4140566_+|TMEM165/GDT1-family-protein
MDALEPLLASTFTVAIAEIGDKTQLLALILAARFSHIKGSKTAIILGIFLSTLLNHFSAAWLGNWAIGLISPEHARYLVAASFFAIALWVLVPDKVDCEESRFYKMGPFIATFILFFIAEMGDKTQIATVVLAAKYDDLALVVMGTTLGMLLANAPVVMAGNFSADKLPLTLIHRGCAVLFALLGAATLMF
>NC_014012.1|WP_013052923.1|4140748_4142215_-|catalase
MTTQANYLTSQNGAPIADDQNSMTAGERGPVLLQDFHLLEKLAHFNRERIPERIVHAKGTGVYGTFTLTKDMSDYTIADHFNGLGKQTETFIRFSTVGGEMGSADAERDPRGFGLRFYTARGNHDIVGNNTPTFFIRDGIKFPDFIHTQKRNPQTNLKDPQAMWDFWALNPEALHQVTILMSDRGIPANYRQMNGYGSHTYSLWNDKGERFWVKFHFKTKQGIANLTPEQADILKGIDPDSSQRDMVAAIADGNFPRWAVKVQIMPEADANTYHINPFDLTKVWPHADYPLIEIGELELNRMPENYFAEVEQVALAPSNLVPGVGVSPDKMLQARLFAYADAQRYRIGTNYNQLPVNCPHATKANHHQRAGAMAGTQCPYNGSQTGGDASVNYGPNSTAAALVEPSNFAEPALRLDGEADRYSRYNQDDFTQAGNLYRIFPEVEKARLITTICGSLSQTTMDVQQTMVEHFTKADADYGKRIKQALGL
>NC_014012.1|WP_013052924.1|4142874_4143123_-|YgjV-family-protein
MDSIIIWEWVGYLASVVVAISLMMSNIKKLRWWNLIGAALFVAYGLAIDALPVALVNFFIVLIDAYYLVKMYKAEKALNEQP

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Crispr_ID: NC_014012_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_12

4175933-4176049

Orphan

Consensus_repeat	Method
TGATGTGGACATTACAGGTATGCTAATGGACGCAATCGAAGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014012_12

>merge|NC_014012|12|4175933-4176049|CRISPRCasFinder
TGATGTGGACATTACAGGTATGCTAATGGACGCAATCGAAGCAAGGCTTAAAGCGAAGATTTAAGCCTTTTATGTGATGTGGACATTACAAGTATGCTAATGGACGCAATCGAAGCA

>NC_014012|12|11|4175933-4176049|CRISPRCasFinder
TGATGTGGACATTACAGGTATGCTAATGGACGCAATCGAAGCA	AGGCTTAAAGCGAAGATTTAAGCCTTTTATG
TGATGTGGACATTACAAGTATGCTAATGGACGCAATCGAAGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_013052962.1\|4187959_4188571_-\|super-infection-exclusion-protein-B	unknown	unknown	gnl\|CDD\|379492
NC_014012.1\|WP_013052963.1\|4188807_4190460_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319167
NC_014012.1\|WP_049791120.1\|4161717_4163364_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_014012.1\|WP_013052947.1\|4171415_4172588_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238279
NC_014012.1\|WP_013052945.1\|4165460_4170017_-\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|236307
NC_014012.1\|WP_013052948.1\|4172728_4173277_+\|SprT-family-zinc-dependent-metalloprotease	unknown	unknown	gnl\|CDD\|179886
NC_014012.1\|WP_013052960.1\|4185915_4187043_+\|site-2-protease-family-protein	unknown	unknown	gnl\|CDD\|100081
NC_014012.1\|WP_013052944.1\|4163772_4165125_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013052959.1\|4184006_4185677_+\|DUF342-domain-containing-protein	unknown	unknown	gnl\|CDD\|377177
NC_014012.1\|WP_083779945.1\|4176156_4177497_+\|alkaline-phosphatase	unknown	unknown	gnl\|CDD\|224699
NC_014012.1\|WP_013052946.1\|4170137_4171049_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NC_014012.1\|WP_013052940.1\|4161277_4161538_+\|DUF5062-family-protein	unknown	unknown	gnl\|CDD\|374730
NC_014012.1\|WP_013052943.1\|4163350_4163776_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_041420064.1\|4180767_4181937_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013052953.1\|4177512_4179987_-\|GGDEF-and-EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NC_014012.1\|WP_013052961.1\|4187624_4187753_+\|DUF3149-domain-containing-protein	unknown	unknown	gnl\|CDD\|371481
NC_014012.1\|WP_041420453.1\|4173433_4174153_+\|endonuclease	unknown	unknown	gnl\|CDD\|185091
NC_014012.1\|WP_013052957.1\|4181920_4182349_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013052958.1\|4182753_4183785_+\|methyltransferase	unknown	unknown	gnl\|CDD\|181902
NC_014012.1\|WP_013052950.1\|4174160_4174889_+\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl\|CDD\|224303

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_013052963.1\|4188807_4190460_+\|hypothetical-protein	gnl\|CDD\|319167	pfam17149, CHASE5, Periplasmic sensor domain found in signal transduction proteins. CHASE5 is a conserved periplasmic sensor domain found in histidine kinases, diguanylate cyclases/phosphodiesterases and methyl-accepting chemotaxis proteins. In Pseudomonas aeruginosa, CHASE5 is the sensor domain in the c-di-GMP phosphodiesterase BifA that regulates biofilm formation and in sensor kinase AruS that regulates arginine degradation pathways. These results suggest that CHASE5 might bind arginine or a related compound.	6.89636e-32
NC_014012.1\|WP_049791120.1\|4161717_4163364_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	6.24344e-51
NC_014012.1\|WP_013052947.1\|4171415_4172588_+\|hypothetical-protein	gnl\|CDD\|238279	cd00501, Peptidase_C15, Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from proteolysis by other proteases until the pGlu is removed by a PGP. PGPs are cysteine proteases with a Cys-His-Glu/Asp catalytic triad. Type I PGPs are found in a wide variety of prokaryotes and eukaryotes. It is not clear whether the functional form is a monomer, a homodimer, or a homotetramer.	3.04678e-09
NC_014012.1\|WP_013052945.1\|4165460_4170017_-\|ATP-grasp-domain-containing-protein	gnl\|CDD\|236307	PRK08591, PRK08591, acetyl-CoA carboxylase biotin carboxylase subunit; Validated.	1.67286e-154
NC_014012.1\|WP_013052962.1\|4187959_4188571_-\|super-infection-exclusion-protein-B	gnl\|CDD\|379492	pfam14163, SieB, Super-infection exclusion protein B. This family includes superinfection exclusion proteins. These proteins prevent the growth of superinfecting phage which are insensitive to repression. It aborts lytic development of superinfecting phage.	7.29522e-53
NC_014012.1\|WP_013052948.1\|4172728_4173277_+\|SprT-family-zinc-dependent-metalloprotease	gnl\|CDD\|179886	PRK04860, PRK04860, SprT family zinc-dependent metalloprotease.	1.16481e-80
NC_014012.1\|WP_013052959.1\|4184006_4185677_+\|DUF342-domain-containing-protein	gnl\|CDD\|377177	pfam03961, FapA, Flagellar Assembly Protein A. Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.	2.18281e-171
NC_014012.1\|WP_083779945.1\|4176156_4177497_+\|alkaline-phosphatase	gnl\|CDD\|224699	COG1785, PhoA, Alkaline phosphatase [Inorganic ion transport and metabolism].	1.30651e-127
NC_014012.1\|WP_013052946.1\|4170137_4171049_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.00362e-70
NC_014012.1\|WP_013052940.1\|4161277_4161538_+\|DUF5062-family-protein	gnl\|CDD\|374730	pfam16691, DUF5062, Domain of unknown function (DUF5062). This family is found in Vibrio spp. The function is not known.	3.54532e-41
NC_014012.1\|WP_013052953.1\|4177512_4179987_-\|GGDEF-and-EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	4.11145e-96
NC_014012.1\|WP_013052960.1\|4185915_4187043_+\|site-2-protease-family-protein	gnl\|CDD\|100081	cd06160, S2P-M50_like_2, Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with additional putative N- and C-terminal transmembrane spanning regions, relative to the core protein, and no PDZ domains.	3.46296e-34
NC_014012.1\|WP_013052961.1\|4187624_4187753_+\|DUF3149-domain-containing-protein	gnl\|CDD\|371481	pfam11346, DUF3149, Protein of unknown function (DUF3149). This bacterial family of proteins has no known function.	3.15909e-07
NC_014012.1\|WP_041420453.1\|4173433_4174153_+\|endonuclease	gnl\|CDD\|185091	PRK15137, PRK15137, DNA-specific endonuclease I; Provisional.	2.99543e-109
NC_014012.1\|WP_013052958.1\|4182753_4183785_+\|methyltransferase	gnl\|CDD\|181902	PRK09489, rsmC, 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC.	4.21287e-80
NC_014012.1\|WP_013052950.1\|4174160_4174889_+\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl\|CDD\|224303	COG1385, COG1385, Uncharacterized protein conserved in bacteria [Function unknown].	3.74652e-98

>NC_014012.1|WP_013052950.1|4174160_4174889_+|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MRIPRIYQDSPLAVGDTLALHDEAASHIGRVLRMSQGEQISLFNGSEHDYLAEIISASKKNVSVKILSSSINSSESPLHIHLGQVISRGDRMDFTIQKSVELGVNTITPLFSERCGVKLSGERLEKKIHQWQKIVIGACEQSGRSRVPEIRPAMSLEAWCGEQTDSLKLNLHPRASHGIQGLSLDVPKVRLLIGPEGGLSETEILKTEQDKFTDILLGPRVLRTETAALTAISALQLKFGDL
>NC_014012.1|WP_041420453.1|4173433_4174153_+|endonuclease
MGLVLSLLLSSPSFASPSHPTSFSQAKRLAKKLYSNELPSTSFYCGCDIKIQGKKWGPDLESCGYQARKQEKRAERIEWEHIVPAWALGHQRQCWHEGGRKNCTKNDPIFRIMEADLHNMVPAVGEVNGDRSNYRFSQWNAKPEQYGQCAMVVDFKSRKVEPPSYTRGRIARTYLYMQAAYGLKIAKSQLKLFKAWDKTYPVDTIECKRDQAIARTQGNHNPFVKQACDSLAVNTQIAE
>NC_014012.1|WP_013052948.1|4172728_4173277_+|SprT-family-zinc-dependent-metalloprotease
MFNLFGSKKTTQVCSAEQAKYEFEDERHQQVAQQVLDCYRQAEASLDRTFSRPEINFKLKGKSAGTAHLQLNLLRFNATLLAENHQAYIDQVIPHEICHLLAYQLYGKVKPHGREWQALMIKIYQLEPATTHTLNTQSVAGKTFDYLCSCGSVPLSIRRHNKIVRGETKYRCRRCKQELKRA
>NC_014012.1|WP_013052947.1|4171415_4172588_+|hypothetical-protein
MTKSSLAIAVAGLFTGAMFSTATMANLDIEEARIPTAVQAIPKVVGRYQALINSLGEQYSEQTHELKMTQMVARQGERLWQQAVRDVQSGGQDDRPLYWGRLAMKTLLKQQAPSFKIAPWQRDINLSAIEKSSRGFSNISFEADTQVKILLTGFDPFFLDRNIDQSNPSGLAALALDGYQFSVNGKQAQIQTVMIPVRFADFDLGIIESLLTPYYRENSLDMIITVSMGRDEFDLERFPGRNRSATAPDNLNILTGANHENPIAPMFNGKTLNGPEFVEFSLPVKAMQSVQGDSAKWKVNDNHGVTTQGKGKFNASSLSELQAATSVEGSGGGYLSNEISYRAVLLQQQFNSKIPVGHIHTPRVKGFDAKTETDIVEQIKAMVIAGAKSL
>NC_014012.1|WP_013052946.1|4170137_4171049_+|LysR-family-transcriptional-regulator
MPDLNGMMLFAAVVRAKGFSQAARETGIPKSTISRKVAQLEEQLDVRLLQRDTRNLSLTQVGALFYQHCISIRDEIEAAKATIENTNNHVSGSLRIAIPVSFSQELIANLCSSFMRLYPNVELDVQFTDSEVGLVGEGYDIAIKYGPLQSSDLVARLLFERQPILVASPGYLKANGTPATPQELANHNGILLGTSRSAPIWPLGKGNRKTMVSFKRKVRVNSAVMVKKLSLDDFGIAMLSNSVCKNELASGSLVPILQEWPIEAFKVYGVYSSRRQLATNISVFLDFFTKRFSSQESLQSLMM
>NC_014012.1|WP_013052945.1|4165460_4170017_-|ATP-grasp-domain-containing-protein
MTSKNQPTNKTQAQSADPLFLKAEHLAKDFSLFPEHSKQSLAEEIKGLLGEDTIQSNLKELELLDVDGYVAKVIQPTLDKNRAGAKRVIADLKGKLITEIHQGPFYSAEIELNFGTRTRRIGFIAQERTTNNGAWMPEHHLAACKAIRKFAELAMPIIYLIDTPGADAGEVANSQNQAHSISKAIAESANVDVPTVGIVIGAGYSGGAIPLAAANILLSLRDGIFNTIQPQGLQSIARKYNLSWQECAKSVGVAPEELYTSGCIDGIIDFSPTDKDERQHNLRRAIISSVEAVENAAVQFVRESKDLREHYDRSLARFLNPSKSLEALEHHAELSVAFNPTMHLNLFGSSYRYLRYLTLRNRIQSISQDQYGRLSKVSVPEGDLLARIQQEQDRVFQSWLSSPDKLVYDEELNKLWGNFTAKRDEASTERNMLTRLLLGEPKENYKKARKALIFNISWSLFHRWKGNAENNFKGLIQYLETLPSEVTQADWPELNKLTVLDVVVHDELREDFIWQCHNILVFNALYDNVVGNLASIAKEAMMSKSLSRASVDNLLHSSIDRALSTQDVTNDKSKFYKWLKYFMNQSNRAELLTKTEQWKSVGFPQLNDSLFVILTYFFERLLPEYFASEEENSEYTGAINPVRIGRRKDFWNRLTMGYQDLLIQKVLRDQKRTGKMGWESIIGKFFTDFDEINGDKMSANLLNFPGFRLSIEDALDKGIRPCGLITGLADFERNGQQMRVGVAVSNTAFQAGAFDMASAEKFSALLIECAKRKLPVICFISSGGMQTKEGAAALFSMAVVNDRITRFIRDNELPVLMFGFGDCTGGAQASLVTHPLVQTYYLSGTNMPFAGQMVVPAYLPSTSTLSNYLSRVPGAMNALVTHPFSNTIDDQLASIDPLMPKPTAQIEDVIANALSTLVPEMMSADEEIVQDDPRELMKPIKKVLIHARGCTAVKLIRKAHDNGIDVVLVASDPDMTSVPADMLKGNDKLVCIGGNTSDESYLNAYSVLKVAEYENVDALHPGIGFLSESPQFAALCVNNGVNFVGPSVHSMTTMGNKSNAIKTSQDNGVPVVPGSHGILSNAEQAVNVANEIGYPVLLKAVQGGGGKGIQVVERQGDMISLFQQTATEAAAAFGNGDLYLEKYVTSLRHIEVQLLRDKFGNTKVLGIRDCSVQRNNQKVVEESGSTMLPPELKEKVLQYTLDLGNATDYMGAGTVEFIYNLDTNEVYFMEMNTRLQVEHPVTEATSGIDIVSAGFDIAAGRSIEALEPQSKGYAIEVRVTAEKAALDSNGVLQLLPHPGMITEYAMPERDDIEIISIAEAGKEVSPYYDSLIAQIICRGESREDVINKLHDYLADHVVIKGIATNIPLLTRILKDGTFNEGVYDTNYLPRLMAELDVPELIAEMEAAAETVGVDTASLRVGESNELKVMAQGAGIFYTSPAPGEADFVKEGDIVTTDQTLALTEAMKMFSQLTLAGYNRQDAVLYPEDKKYRIERILNSNGQQVSQSDLLFVVSPVDS
>NC_014012.1|WP_013052944.1|4163772_4165125_-|hypothetical-protein
MPDKITKKKLNRIIDKIVDVSSRALGGSVLLLLAHFGVMSQAQARIHDHSEQSEFNLSVNGFGTLGLVRNSSDELYFHRELSMNASDSEYSFKTDSLLGLQVNADLTESLDAIAQLVLKDRASDMALDSLELLFLRYRPNRDWAIRLGRTNTDLYIHSEYRNVSYAYLWSRPIPEFYAITSVIAKIDGVDISYTHNLEGGTWETKLAYGVTHSVLAVQANRFEIDIKNVFALTSIYTWDEWTFRLAAAAVEVDELDFLSNDVVDGLNLVPDTLWPEASKMAQDIDGPGQKLQYYALGLQYDHMNWVIQSELGYVDSDWGIIQSFYNGYLSVGYRVDEMTFYGVLANIDNSGEPTSYASPQLPAHFPLQLTAQINALYEGALEAFTSSKIEQTSLSLGMRWDLYPNTCIKFQWDHIWIDQRSAAMWTQVQEQVGDTEVDLLSVNFSFIFNL
>NC_014012.1|WP_013052943.1|4163350_4163776_-|hypothetical-protein
MKYLIGLLTLILTLPLRAEGDLLVVVSRESHVESLTKSEVVDLFMGRYVNFPNGDKAKVFDLAPKSELKGLFYQKLVNRTEAQINAYWARLLFSGRNTPPKETESADQLIHELLSSRHGIGYISSQDLTNSLKVVYRFEAL
>NC_014012.1|WP_049791120.1|4161717_4163364_-|diguanylate-cyclase
MRRFRHQLYFKVALAIALSVALVAALSSYFFYFQEIERNELGLWEHVNQLSRTIENTASIAVYVQDAVLAREIIDGLAINDVVSEAELISDPGFSVYSGEVTLIGREGVSTLILYHPFSESEVIGQLNILPNEAFIHFNAKNSAVNQAQQLALLTLVTALLVSFIVHKALTSPLNRIINRFEEVKPGEDIKLTVPRFHQKDEIGSLVRGINSLVSSLNQSIDSERNLRETTQVLEKKFRLIFEQASAGICLIDNDNLLVTANPAFQRIIYKSHTISDAIGLRLTDWFYNKLQLESFLTDIRQSHNLDTVALDLKMKTLAGSPDCWVHCLFSKVLDDDMQSCLMIEVLMYDVTERTEREINTRFEADHDGLTHLRNRRAGSRALIELFDRAEANDKIAVLMNIDLDNFKIINDTNGHEAGDMVLIEIGRRMMAVFRNDDLCIRWGGDEFVVGCYFDSSRFEERSLPAIEKLASELRCVLNQDVKLSSGEDIKIGASIGIAMYPQHGDNLQSVLKAADNAMYVSKQKGRNQYSIFDSNIMSEPDSCPKSE
>NC_014012.1|WP_013052940.1|4161277_4161538_+|DUF5062-family-protein
MKQGKHDVQLLKLAMEIGVGYAKKRGFDDFGKGISPKDKVECIYRLLVTDKLIQPLAVDKEDGPNMKHKLILWISRQLPEEHELLN
>NC_014012.1|WP_083779945.1|4176156_4177497_+|alkaline-phosphatase
MTIFKLCILAGAALVGTMSVAAQAMTPAQTMLGDAPSVPKNIVIMIGDGMGPAYTSAYRYYKDNPDTQEIEQTVFDRLLVGTSSTYPARVSGYVTDSAAAATALATGVKSYNGAISVDINKQTIPTIMEKAKALGLATGVAVTSQINHATPAAFLSHNESRSNYDALAKSYLTTDTDVMLGGGKKYFPVSLIEKFQAKGYQYLSDFNQLDSIKQGKVIGLFANVQLPWAIDDNDKNKLSKMTAKALELLSQHDKGFVLLIEGSLIDWAGHNNDIVTAMGEMEEFANAIEVVEQYIRNNDNTLMLVTADHNTGGLSIGANGEYSWNTSIIRGVQASPDFIANDALIHDDWLARVSLNLGFEPNEDEASQLARARMQGKEVMTTSIKHLIDSRSNTGWTTGGHTGVDVQVFATGPAASLFAGYQDNTDIANKLISLLPKAKSKSQSNK
>NC_014012.1|WP_013052953.1|4177512_4179987_-|GGDEF-and-EAL-domain-containing-protein
MTMQPESRTIFISLKWKLLVAVLIILTILGGFLGGFAYRQLINQQNYLLEFQRDKLAQNLETSISLSVEHSLSAAQQIALLVNDAQQSPSGYQAMLALHWPDLQLYWELERLSLMSLSGQVLAHAGRSLESEELGWFESAAVNLDPHWRIVCHRECVIQVLVPHLLQGEPHFLFMESGLTDILARFRINETFDLAVLAPTTDADKGPSYWGRQVYSISNKHTSLFQLELAAAQFTWEQIESWGGIYKVGDELSVLWIFPLAKGESPPAILVINNISDWQSLLNEFQESMLGTLLFSLVLSGILVILAAWAPVVSLSRHATLLPMLAEHDFDTLKALSPKTSSLIVDEVDLINIATLNLAERLQNLELEVDEYTCELERLAMLDTLTGLPNKAMLNHELKKTIACVGRIHDKIALMFLDLDEFKRINDTLGHSQGDELLKIVAKRLNHSVRAMDTVFRQGGDEFLILLRGIRSEEDVRKVIHKIFACLQQPIVLGHHKLIVTTSIGVAYCESNNVRAEELIKYADLAMYQAKDAGRSNYRVFTQEMLQRANNKLMIEQDIGAAIEEKQLSLSLQPIVSLPDGKVKGFEALIRWHHPERGLIMPGDFIPDIEDSEAIIQVGNYVLEEGGAILARLIEQGWEDLYLAVNLSAKHYMDPGLIPLVQRILSKYNIPPQSLLLEVTEESVIENVDLALSSMRSLKCLGVRIAIDDFGTGYSSLSYLKQLPFDVLKIDRCFTSGVLENSVDTHIVTTVIDLAHNLGRTVVAEGIETQEQCDFLAAARCELAQGYLFSKPIDERKAFRILNEIEGDGVWPVESLPQLAKLGS
>NC_014012.1|WP_041420064.1|4180767_4181937_-|hypothetical-protein
MKLAANWFIGIFLMHVSFFSYSSEWQLNGFVGQGFIAADDTQFVVGEDDTSFNITEAAFAVSWKPMEHIRIASALSYRQWGSLAEGGANFDYLFVEYSHQVGDGILGIRGGLFKNETGFYSSTRDVPFTRPSIMLPQSIYSDYFRDAQLHIEGGDLFGMHQIWNGAIDWHVSVGKVDVTEDLDRNVMGSEKLGCFGSERYYSGDIEFQNDNLRFGLTYYDAEVSYHPYEETYYPGDIRLKNWVVSGQLRYWILEFTAEYMTGDRLINGLVFPPMADEFVDSGIGYYLDFRAYLPHEVELFVRFDKHIDDKDDADGKEFEATTGLPAYFSYTDDWTLGARWFLNSDWLLAAEFHWVEGASWVTPIVAPDPSKQSKHWSMFALQLSYRFQW
>NC_014012.1|WP_013052957.1|4181920_4182349_-|hypothetical-protein
MRLLATWMLMLYLFCSHSSAAQVIVNNSAIDFPLPAQELRLIFSMQKIYWPDGQKIQVFILSPSSKLHKEFCFKQLDMMPYMLQRRWDRLVYSGTGERPIILNNEAEMQAQIASTPGAIGYVADLSIGGVNRLTRSFYETSR
>NC_014012.1|WP_013052958.1|4182753_4183785_+|methyltransferase
MLTNPSQVILRNSNLFDNQNVLVINYEDDHLPKHLLEHANKVTALALDYHHHLQMEPETSSELSIFFGHSLPNDELFDTAIIYYPKAKALAAYLINLAGQHLKPGGQLVVVGENKGGVRSIVKQIPAYFDKPFKVDNARHCLLYISELIDQAPKIKLADWVSKYQLDTPQGEITVCNLVGVFSEKRLDEGTKLLLSNLPRMKGRVLDFGCGAGVIAAALLKAQPKLQIECVDINAMALASCELTLKANNFIAATYPSDGLNQTQDKFDGIISNPPFHDGLKGTTEIVKNFVSDSVKKLKKGGVWHIVANRHLAYSDIILDNFGQVNVIAENNKYKIYSNKFNK
>NC_014012.1|WP_013052959.1|4184006_4185677_+|DUF342-domain-containing-protein
MLSPELIELSADNSFAEFKVTPNTHGPLTEAAILTLLTLPDFDCLFPLEPSIQKAVIQVNQLCGQDDGQFEQFFQIAERRDGLIEVEINEDKMSAQMQLTASWGGNEVTIQDILKSLKTNNVGMGLSKVKIQTLLKQLTQLQPGETCRSVIATGKPSVNGTNAKLERKVPLARERLLQPQEREDGTVDMRNLGSVIMVKPKDLLMVKHPATLGSKGYNIHGEVLFPVPGKDLQLTEGDGSGLDPANSNHLIAIVAGQPVETKTGMKVDDVLNIKDVDVGYGNVDFKGSVMITGDVHEGMVVKSSGDITVMGFVDSSTLIAEGDVIVSKGIIGRQLKENELSTKIQAKGQICAQFIQYSDLDAQGEILVTKQLLHSHTKTKQKLTVSDANGRRGDLVGGIVKADKGLKAVIIGATAGTKTEVFCAMKQSDLKKNLKELDQSIKSMFVAKLEIQARLKKLPPKSEWQGDAMMVEQVKMMLDEKQRMLDELAREELEYALIKQEIDGYYQENRIEAHKHIFANVEIHIGQAFNRTQREHGTCMVFNQDQEITFDYNNRS
>NC_014012.1|WP_013052960.1|4185915_4187043_+|site-2-protease-family-protein
MELLKIDCLGKELRLEGSMAGWQQLFWGDTLVSVKQASIDNEGLKSHDFELSTQVNPVNIDTAPEQAIPSQRIKISLEIDLIWQPFNLDYRLMKDGSLVDQGSRNSKDIERQVPVKPVEAKRKVSLVGLASLGFKLLKSAKVIKLVLAGASVAAYSWLFSFQFALALIACLVFHEYGHIRAMKHFGMKTKGIYLIPFMGGLALSDEKINTRWQDVVISIMGPTFGLLMSIMALIAYWLTGNVFFAGLAAFNALLNLFNLLPILPLDGGHILKSISFSMNSILGLAACVAGAAVGVYLSYTLGLALLGFLLLIGSLEIVFEWKTRHQSHLLPLDRYGQIFSTVWYFLTVGALIGIIWYLAGSGDDILGLPLKILQS
>NC_014012.1|WP_013052961.1|4187624_4187753_+|DUF3149-domain-containing-protein
MAFWLDLMFGNAIGLMSMIVIFCTIGIMGYLMWMFIQKSKPE
>NC_014012.1|WP_013052962.1|4187959_4188571_-|super-infection-exclusion-protein-B
MQKINTQIFKPSMPKQLIFSSMLWLAIVSGALLFAPVGILTSVHLEAAVSANSHFIGLGFIIGIAYLITQVVNYFLDEAISALKIKRTTEIIEEKVRLLDPTERALLREFFLQGETVLTLPQNEPAVKSLLATSIIELLGNQKNYAIQGSTSDYKISMRARIYLNRQVLRLPVGEPSQEEMKNLIKARPTFANNVTTPRKHAA
>NC_014012.1|WP_013052963.1|4188807_4190460_+|hypothetical-protein
MHTFTSRLIKSQIGRKLTISIILFSSLITLITTGFQLVNDYKGDVDRITRQFTSIEKVNLDVLAASIWVIDERLINTQINGLIQLPDITYISIHDDSGQVWTSGTPTPENTIEKTFELTYDSGNDTIAVGSLLVQADLKAVYEKLLKRAIIILFFNAIKTFIVAGFILFLVWYMVARHLHMLSLYCQRLDLDSPFEPLKFDQNNKEGDEFHQVSSAINTMQQQLRTSFSDIKKSKQELQDALTDRERLLALETSYKEELARQVKERTQELEQSLLVLKRAQEVLVEQEKMAALGGLVSGVAHEINTPIGICLTAATSQMIHVKELLQLIHGEDATLEEINDILEEHQESCALIVNNITKASTLIQKFKSVAARQNPEELKTFNLRQALIDSHESMKILFTEQEVEVQFDIAPELEIKTNQSLLKQITGNVLSNSYSHAFKKVEKSIIIIRAKLVDNNLSISIQDNGPGISTEAATHIFEPFYTTSRSEGATGLGLSAAYNAAILLKGNIRFEPECELGGACFLISFPITPYSTDDELSDPISQSGLMNQV

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Crispr_ID: NC_014012_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014012_13

4896218-4896324

Orphan

Consensus_repeat	Method
ACAGATGAGGGAATCGCAGCATGATGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014012_13

>merge|NC_014012|13|4896218-4896324|CRISPRCasFinder
ACAGATGAGGGAATCGCAGCATGATGAACTTGGTAATAAATAACCAGCAGGATGCACACTTTCAATGCCAGCTTATCGGCACAGATGAGGGGATCGCAGCATGATGA

>NC_014012|13|12|4896218-4896324|CRISPRCasFinder
ACAGATGAGGGAATCGCAGCATGATGA	ACTTGGTAATAAATAACCAGCAGGATGCACACTTTCAATGCCAGCTTATCGGC
ACAGATGAGGGGATCGCAGCATGATGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014012.1\|WP_013053542.1\|4889108_4889294_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013053540.1\|4887998_4888430_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NC_014012.1\|WP_013053550.1\|4897612_4899097_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013053556.1\|4904561_4905746_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|367519
NC_014012.1\|WP_013053538.1\|4885723_4886908_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225375
NC_014012.1\|WP_041420495.1\|4903911_4904403_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|236773
NC_014012.1\|WP_013053543.1\|4889296_4891093_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NC_014012.1\|WP_013053539.1\|4887193_4887871_+\|acireductone-synthase	unknown	unknown	gnl\|CDD\|319768
NC_014012.1\|WP_157608907.1\|4893963_4895514_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|312032
NC_014012.1\|WP_013053557.1\|4906771_4907791_-\|NAD(P)H-dependent-glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|234629
NC_014012.1\|WP_013053546.1\|4893438_4893807_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224639
NC_014012.1\|WP_013053558.1\|4907897_4908389_-\|protein-export-chaperone-SecB	unknown	unknown	gnl\|CDD\|180234
NC_014012.1\|WP_013053544.1\|4891221_4892544_-\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013053552.1\|4900553_4900733_+\|hypothetical-protein	unknown	unknown	unknown
NC_014012.1\|WP_013053541.1\|4888589_4888994_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NC_014012.1\|WP_013053545.1\|4892540_4893398_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_014012.1\|WP_013053554.1\|4903210_4903744_-\|molybdopterin-adenylyltransferase	unknown	unknown	gnl\|CDD\|181837
NC_014012.1\|WP_013053551.1\|4899251_4900265_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|227311
NC_014012.1\|WP_013053559.1\|4908495_4908930_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NC_014012.1\|WP_041420138.1\|4900757_4902416_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910

Protein	Function_ID	Function_description	E-value
NC_014012.1\|WP_013053557.1\|4906771_4907791_-\|NAD(P)H-dependent-glycerol-3-phosphate-dehydrogenase	gnl\|CDD\|234629	PRK00094, gpsA, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.	0
NC_014012.1\|WP_041420138.1\|4900757_4902416_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	2.06686e-73
NC_014012.1\|WP_157608907.1\|4893963_4895514_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	9.84037e-20
NC_014012.1\|WP_013053556.1\|4904561_4905746_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|367519	pfam03486, HI0933_like, HI0933-like protein.	0
NC_014012.1\|WP_013053538.1\|4885723_4886908_-\|hypothetical-protein	gnl\|CDD\|225375	COG2819, COG2819, Predicted hydrolase of the alpha/beta superfamily [General function prediction only].	5.63278e-05
NC_014012.1\|WP_041420495.1\|4903911_4904403_-\|C40-family-peptidase	gnl\|CDD\|236773	PRK10838, spr, bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase.	3.35618e-48
NC_014012.1\|WP_013053543.1\|4889296_4891093_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	0
NC_014012.1\|WP_013053539.1\|4887193_4887871_+\|acireductone-synthase	gnl\|CDD\|319768	cd01629, HAD_EP, Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep. Enolase-phosphatase E1 (also called MASA) is a bifunctional enolase- phosphatase which promotes the conversion of 2,3-diketo-5-methylthio-1-phosphopentane to 1,2-dihydroxy-3-keto-5-methylthiopentene anion (an aci-reductone) in the methionine salvage pathway. The catalytic reaction is carried out continuously by enolization and dephosphorylation, and the enolase activity cannot be classified as typical enzymatic enolization. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.68646e-103
NC_014012.1\|WP_013053546.1\|4893438_4893807_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	1.16864e-27
NC_014012.1\|WP_013053558.1\|4907897_4908389_-\|protein-export-chaperone-SecB	gnl\|CDD\|180234	PRK05751, PRK05751, preprotein translocase subunit SecB; Validated.	7.10664e-88
NC_014012.1\|WP_013053540.1\|4887998_4888430_+\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	4.132e-29
NC_014012.1\|WP_013053541.1\|4888589_4888994_-\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	1.37414e-30
NC_014012.1\|WP_013053545.1\|4892540_4893398_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	6.59477e-66
NC_014012.1\|WP_013053551.1\|4899251_4900265_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	8.37619e-67
NC_014012.1\|WP_013053559.1\|4908495_4908930_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	5.41127e-31
NC_014012.1\|WP_013053554.1\|4903210_4903744_-\|molybdopterin-adenylyltransferase	gnl\|CDD\|181837	PRK09417, mogA, molybdenum cofactor biosynthesis protein MogA; Provisional.	8.2339e-122

>NC_014012.1|WP_157608907.1|4893963_4895514_+|alpha/beta-fold-hydrolase
MALLGTIVISSMILSLPAFASADTNNSENNTGAPASQNEQTCYLDGLSEQVSCGFITVPENPTKPDGKQIEIHYAVLPAIKSDNHSQAFLAIAGGPGQSAIDNAAGFSQMFRKIRQNRDILLIDQRGTGRSNILNCQGDGLENALAINEADFDVATETQACLDELDADVTQYGSLNALDDFEAVRKHLGYKKLDVYGISYGTRMAQLYLRYYPEVLSTVTIDGVVPMQQSVLAIGNAISRAFDLLIKDCNTNKLCGAQFPNLKADLSRIDAKLALAPIVSQIRDPLTGEATQLTMTRAKFMGAIRMALYMPNVRALIPHAISEAAKDNFQPILGLYSLTIDSTGIAMGMHASVICGEDWQRLTTAERDDANQTYFGREMVTTFEQSCAIWNMPAVDADFSAPISSDIPTLVLSGELDPATPPSWGELAMEKLTNAKHFIAPYATHGVAHQSCGNELIAELVDTGSVQELDGECLNKDVSRNFYLNASTVEAIPAPEHKQDPIQEPKQAIAQGASHD
>NC_014012.1|WP_013053546.1|4893438_4893807_-|GntR-family-transcriptional-regulator
MLELINVNPSSGEPIYRQLSEQIVRLIVGGQLETEQVLPSVRKMAEHLSVNPMTVSRAVQLLVEQGWLERRRGQATRVAKREHSETTSSAQLLKPEVDELVSLAKQLGIGRDELIKLIDSCW
>NC_014012.1|WP_013053545.1|4892540_4893398_-|ABC-transporter-ATP-binding-protein
MDMNQAPILEFNKVSKHFSVKDGVGKIAINGLSIKLFPGMLVGLLGKNGAGKSTLMRCALGIIEPSSGEITTLGEPINQLSSEAKAQIGYVPQQPFGYEGFSVSRALELHRSFYPAWDRELENTWLERFDLDSKQQVQRMSVGQRQSLALIMAMAYRPKLLILDEPVASLDPIARRKFMADLFELALESGSAVLFSSHITSDLERVASHLALMRSGELVLFKEMDSVREEVKLLTLANGEDIPTGLNVLNHQGNKVLVDNFSDVKYPDMAAESLNLERLFMELHR
>NC_014012.1|WP_013053544.1|4891221_4892544_-|hypothetical-protein
MSSANPELIQAKSDNGTRLGVLQRRLAGVSRFWFYDHGSASFMGVALLGLLMLVPLIALDKLEIVPMILGMMQISVSAAVAWQLIRLAATEWSILIPEYRHNIFFQCGLMLLSSFTIGTLVSMLVGVEGAFSLLLLATGLGLSFIYLCLVKKGVFYLSILLYLFLIFLDSIDEHISPVVMAAVALANLALVWVIWKKSAVSGWHPDARSVYLNALEMGGVWLPTAKSYPLLRKLEKYLHPVNFFMGPLLALLIITMPIITLIVAAFAQLVGLQIPALFMLAQFSCMACTIVHWSRIQRWRGVETLFMLPGFSGKQGMIDAFNRSQTHLLILFTLIMAVTAALVSLFNPAITLAIWFHLVLSTFFSCGFLLGLGCACKTVLHLSMIMLIFVANSAWVSSSFRGFVEETDVWLWLAGDLALVGISILTIWWGSKKLWNGDLV
>NC_014012.1|WP_013053543.1|4889296_4891093_-|long-chain-fatty-acid--CoA-ligase
MSLEQYHLTRLIKQQSLQLGDAIALEGYEMAAPWYQVSWRNFDSISTRVAQALIHFGFEAQDRVVILAQNSPQWTCADIGSLKTRAVVVPIYPTSTFGQASYIVDDAEAKLIFAGDQTHYEMACKLTQVCNSLVQVVVFDKSVTLEDNENHHYFDDLIADTYPEKTLIELDKRLEAANLDDLLTLIYTSGTTGDPKGVMLDYRNIASMVRQHDNFLPFTPGDVSLAFLPLSHVFERGWSFYVLCRGGHNVYLNNPMAVKEAIVQVRPHTLCVVPRFLEKVYSAVQDTVSKAPSSRQKLFAWAMNLGHRQSEVGQGREKASFCLSLQWKLADKLVFSKLKQVLGGRLKFMPVGGAALDPTVSAFFQSIDVPVLCGYGMTETTATATCNTLANRVPGSNGKVIPEVEIKLGKDNEILVRGDTVMRGYYNRPQETADTFEDGWLKTGDAGRIDEQGNLFITDRIKELMKTSNGKYIAPQRVEGKLACCPFIEQVAIVADAKNYVTALIVPAFQPLETWAKEQGLHYDSPMDLLRHSQVIEHYEQRLKILQSDLAGFEKIKKFTLLPEAFSMEAGLITPTMKLRRKVIYHKYASEISAMYGR
>NC_014012.1|WP_013053542.1|4889108_4889294_+|hypothetical-protein
MLECWNAGMLECRNAGMLECWNAGMPECWTKLKLEALHPSEFSIKKGMPKHPFIITRIDLT
>NC_014012.1|WP_013053541.1|4888589_4888994_-|acyl-CoA-thioesterase
MPETFFSLDIQPRFNETDGLGHINNTVLPVWFEAAREPVFEIFNPSLDLSQWNLIVAGFTIAYTSPTNYGSRVSVKTWISRVGNSSFEVAQQSWQGGKMTAEAKTTLVHYDYGIEKSQPISAEVKSKLETLTGE
>NC_014012.1|WP_013053540.1|4887998_4888430_+|acyl-CoA-thioesterase
MLDKFIAENPVYTEITVAWGEMDALQHVNNVAYFRYFETARINFFSQINLMDQLQATQVGPVLSDNNARYKRPVTFPDTLLVGVKISDIKADRFMMNYTVFSKAQAAITTLGSSQVVMFNFNTGKKATLAPELLDALRSYAEA
>NC_014012.1|WP_013053539.1|4887193_4887871_+|acireductone-synthase
MGIRAIIVDTAGTTTDLSFIKDTLFPYSAKALPDFLKENQHNVLVENCICDVRDIALEPDASLERVVEILQQWVAEDRKATPLKTLQGLIWKQGYAKGEFTGHIFPDFIQAIDGIKQQNMRIYSFSSGSAEAQKLLFAHSDGGDLTPKFDGHFDTRTGNKLFKQAYCNIINTISLAPKQVLYISDVVEELKAAEEAGMRTIQMVRSDDQRTGSHKQITSFAELKF
>NC_014012.1|WP_013053538.1|4885723_4886908_-|hypothetical-protein
MIKQLILALPLFISLVLSSGASLADNLDKQSRNTTLDVTTSLSDKPISFTVTLPPSYFKNTDKRYPVMFDFHPRSQAYLNGMHDWMSHNGDWPWLETIIVTAPDDNKILGDWKKLAIDERGDTKLLDFMQQGLLPAIDKQYRSNGFRIMNGFTGNAGLGLYTLINRPDLFNAYFVASPVLSDDFAYVIKDAPKKLAAMKGKPRFLFMSTSDSGFEQRQLASFAEMEKIIKDNATPTLDYRIKRFDGTYYMTQPILATAYGIELLFNDYHQVLKPDSQISRQGPEAILAHYKYLSQEKYGFEVPATDSLIALAKAESDKGTKKGTDKALDIYLLAVKSYPNSHTAQDALALAYAEEEEFDLAIQHEQLALDNTDHPFWTNKYSQSLAAFKANKLL
>NC_014012.1|WP_013053550.1|4897612_4899097_-|hypothetical-protein
MQSITHPSPELLAALGSISDFKVAAAFGVRPYQVRDLRVIHNIPTVLAAIERQSFDWGEESDGLLGTMPDTKLARLIGTSRSIVNARRDKLKISAFVPLIFELSRSGSKQHCWLPEEDLLLGTDFDNIIADQLNLNQLQVTHRRYQLSVDPFRRSATIQWTEHMLDNLGEISDKDFAEYFEICVASVYLKRLLLSIPALNAIDPPSPPCIPKAAIKLLGIKTDVELTHEFSIGRWPIRVNRLFRGLAPAQRLPRSNQIEWKLEQEAMLGKVSDLDLGKIMKVSASSVKYRREALHIKPYVRVKEVDWNEFKLKGLGRSEDLALAQAWNCDVSKVRDKRESLHIPEHHGPRCWLNSELIMLGRLSDPETARRLGVSSTVVRNKRIEINIKPLLSQKKFIWTKKRLALLGTMADERLAYQLKVTPNVVSKKRVQLNIPIWSSPHKGTWSNPKAIAKLGTMSDPDLAKFLGNTASAVYRKRKQMGIPAYVAKIAMLS
>NC_014012.1|WP_013053551.1|4899251_4900265_-|helix-turn-helix-domain-containing-protein
MKQITILAAGNVVAGGIFGFLDVFSFCNAYWRRINPDAKEDLFHCHVVSYDGLPVNTNQNIQIPTIGLDKAEDILQADAVILASAFVTSREDFQLYLNEFEPLFEPLRVFAASGKPVAAYCSGTLMLAASGVLNGRRATTVWWLKEMFQRNFPDVNLCMDKLVISDEHIHTAGATTSNLSLALHLIGILAGEQIAHQMAKILLIDPNRTSQQAFMSMDLSIGANNHQDELVTKIQNWMQAHIGQSLLLDDIADKFAVGKRTMIRRFKKAINETPASYMQRLRVDEAKRLLETTELALEQIVGRVGYEDVSSFRKLFIQLTSLSPRAYREKFNTHACC
>NC_014012.1|WP_013053552.1|4900553_4900733_+|hypothetical-protein
MSQSNKQLVMSLSYLGISWALLFWLHFSTEPNIFAHLVAIPSLLMFTGYSAYQINKNGA
>NC_014012.1|WP_041420138.1|4900757_4902416_-|methyl-accepting-chemotaxis-protein
MGFLSSWSIKRKLMAVMLVFGLAGLTILVDVLMNTNFVAEKFEEYDQAAVSSQKYILFISRDINYVSRLSRSIMLGDDFDKNYSLLDTRIRAIYSHFDNLEASVRLVSDKEARSRLNQLIAPSKQATKAFLEDGRARMLQLKSVDRTPEVLQGAWISYRKGASPFASKARISFKSLVTAEEGVREEIQQAAISSMAEMKQQLVLIIIASFLFGGLLLFFVGRTILDSVRTLTRSINEIESNADLTRRIEIQSKDEFAALSRAFNLMLDKFQSSIISVSDTSKQLALSAQGMAKVTSETAASVQGQRHELDMVATAMNEMTATVVEVAKNANDAADAANQTDLQSKEGMQVVNNTVETIVGLAAEIESAAEVIQSLEKDSNQIGTILDVIKGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLASRTQESTEEIQAMIEKLQGGAKTAVSVMSDSRKYADDSVSHAKSAGEALQMITQSIGTITDMNTQIATAAEEQSAVSEEINANIVNINHAAEEAAEGANSTSTESERLAEMAKELQRLVQQFKI
>NC_014012.1|WP_013053554.1|4903210_4903744_-|molybdopterin-adenylyltransferase
MTKAKIGIVTVSDRASAGIYEDLSGKAIIEVLNQYLTSEWEPVYEVIPDEQDVISATLIKMADEQNCSLIVTTGGTGPAKRDVTPEATEAVCDRMMPGFGELMRAESLKFVPTAILSRQTAGLRGDTLIVNLPGKPKSIRECLDAVFPAIPYCIDLMNGPFLECDESVMKPFRPKAK
>NC_014012.1|WP_041420495.1|4903911_4904403_-|C40-family-peptidase
MLLLFMSGCSSQLPDEVDADEPTNLAATKARMSAAAPVNIKELALKKKFMAFHHEWKGTPYRYGGMSKRGVDCSALVYLAYKEVLGKNLPRTTADQKDLGHLVSKGELKTGDLVFFKTGWSSRHVGIYLGHSKFLHASASKGVIISTLNNSYWKRKYWQSRSL
>NC_014012.1|WP_013053556.1|4904561_4905746_-|NAD(P)/FAD-dependent-oxidoreductase
MKHHDVIIIGAGAAGLMCAATAGYRGRDVLVLDAAKQAGKKILISGGGRCNFTNQKVEPSNFICGNGHFVKSALARYRSSDFIDLVERHGIEYHERDHGQLFCNDSAKEIVTMLLTECEWAGAKIKLRTEIGKITQADSGKFEIATDNEIYSCDSLVVATGGLSMPKLGASPLGYQLAEQFGLKVLPTYAGLVPFTWQPEQKVKFEPLSGIAVPSTITAKDGTQFSEALLFTHRGLSGPAILQISNFWKPGETISINLLPGIDARAAIELVLANHPKQNLRNTLSHWLPKRLVEALFDEALLSKALNQLIHKELEQLAVDLESWEILMNGTEGYRTAEVTLGGIDTDELSSKTMEAKSAAGLFFIGEVMDVSGWLGGFNFQWAWSSGVAAGQAV
>NC_014012.1|WP_013053557.1|4906771_4907791_-|NAD(P)H-dependent-glycerol-3-phosphate-dehydrogenase
MKNTADITVLGAGSYGTALAISLASNGHRTLLWGHNPEHIENLKRDRANEAFLPGITLPDLLIPEADLATALAASNNILVVVPSHVFGMVLSQAKPLLREDSRIVWATKGLEPETGRLLQEVAEDELGDKYPLAVISGPTFAKELAAGMPTAISVAGTDDVFTQDLVELLHSPKRLRVYANNDFIGLQLGGAVKNVIAISAGMSDGIGFGANARTALITRGLAELTRLGEAMGAQTSTFMGMAGLGDLVLTCTDNQSRNRRFGLALGRGQGVEEAQEEIGQVVEGYRNTKEVYALAKRLGVEMPITEQVYRVLYEGGTPREAAVTLLAREIKSETQDSE
>NC_014012.1|WP_013053558.1|4907897_4908389_-|protein-export-chaperone-SecB
MAEVVANNEQQDPQFNIQRVYTKDISFETPNSPAVFQKEWNPEVKLDLDTRSAKLADNVFEVVLSLTVTAKNGDETAFLCEVQQAGIFAINGLTEQQLAHSLGAYCPNILFPYAREAVGSLVSRGTFPQLNLAPVNFDALFAQYVNQRQAGAEEAAKTEEASA
>NC_014012.1|WP_013053559.1|4908495_4908930_-|rhodanese-like-domain-containing-protein
MQEYIEFLKAHPMLSLAWIGLLIGLIVSVFKASISKVTTVDNQQATLLMNKQDAKVIDVREKSEFKKGHIVDALNVPLSEIKNNQLSALEKFKASPIIMVCNAGMVSSQASQLMVKAGFESVHNLKGGMGEWQSSNLPVTKSKR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014012_3	3.1\|1024951\|28\|NC_014012\|CRISPRCasFinder	1024951-1024978	28	NZ_CP040642	Agrobacterium sp. T29 plasmid unnamed2, complete sequence	271067-271094	5	0.821
NC_014012_12	12.1\|4175976\|31\|NC_014012\|CRISPRCasFinder	4175976-4176006	31	MK448838	Streptococcus phage Javan100, complete genome	26858-26888	7	0.774
NC_014012_3	3.1\|1024951\|28\|NC_014012\|CRISPRCasFinder	1024951-1024978	28	KX513877	Human gut gokushovirus isolate SH-CHD14, complete genome	4407-4434	8	0.714
NC_014012_12	12.1\|4175976\|31\|NC_014012\|CRISPRCasFinder	4175976-4176006	31	MF459647	Erwinia phage vB_EamM_Joad, complete genome	174271-174301	8	0.742
NC_014012_12	12.1\|4175976\|31\|NC_014012\|CRISPRCasFinder	4175976-4176006	31	MF459646	Erwinia phage vB_EamM_RisingSun, complete genome	174018-174048	8	0.742
NC_014012_6	6.1\|1981094\|34\|NC_014012\|CRISPRCasFinder	1981094-1981127	34	NZ_CP017759	Cupriavidus necator strain NH9 plasmid pENH92, complete sequence	54235-54268	9	0.735

1. spacer 3.1|1024951|28|NC_014012|CRISPRCasFinder matches to NZ_CP040642 (Agrobacterium sp. T29 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.821

gtccacagtttgccatccttggcctgtg	CRISPR spacer
gtgtacagtttgccatccttgaccagta	Protospacer
** .*****************.** **.

2. spacer 12.1|4175976|31|NC_014012|CRISPRCasFinder matches to MK448838 (Streptococcus phage Javan100, complete genome) position: , mismatch: 7, identity: 0.774

aggcttaaagcgaagatttaagccttttatg	CRISPR spacer
attctcaaagcgacgatttaagcctttcaca	Protospacer
*  **.******* *************.*..

3. spacer 3.1|1024951|28|NC_014012|CRISPRCasFinder matches to KX513877 (Human gut gokushovirus isolate SH-CHD14, complete genome) position: , mismatch: 8, identity: 0.714

gtccacagtttgccatccttggcctgtg	CRISPR spacer
taccacagtttgccaaccttggcgaaca	Protospacer
  ************* *******  ...

4. spacer 12.1|4175976|31|NC_014012|CRISPRCasFinder matches to MF459647 (Erwinia phage vB_EamM_Joad, complete genome) position: , mismatch: 8, identity: 0.742

aggcttaaagcgaagatttaagccttttatg	CRISPR spacer
aggcataaaacgaagatttaagcccatacga	Protospacer
**** ****.**************. *   .

5. spacer 12.1|4175976|31|NC_014012|CRISPRCasFinder matches to MF459646 (Erwinia phage vB_EamM_RisingSun, complete genome) position: , mismatch: 8, identity: 0.742

aggcttaaagcgaagatttaagccttttatg	CRISPR spacer
aggcataaaacgaagatttaagcccatacga	Protospacer
**** ****.**************. *   .

6. spacer 6.1|1981094|34|NC_014012|CRISPRCasFinder matches to NZ_CP017759 (Cupriavidus necator strain NH9 plasmid pENH92, complete sequence) position: , mismatch: 9, identity: 0.735

tggctaagccaactccggcgagtcaaacttcggt	CRISPR spacer
tggctatgccaactccggccagtcatgccatgcg	Protospacer
****** ************ ***** .*. .*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1688865 : 1698284

Catovirus(14.29%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013050754.1\|1688865_1689621_+	glycosyltransferase	A0A1V0SAH6	Catovirus	2.8e-13	38.8
WP_041419758.1\|1689720_1690884_+	glycosyltransferase	NA	NA	NA	NA
WP_013050756.1\|1690876_1691881_+	GDP-mannose 4,6-dehydratase	M1I4U0	Paramecium_bursaria_Chlorella_virus	2.8e-69	42.0
WP_013050757.1\|1692331_1693450_+	GDP-mannose 4,6-dehydratase	M4QRT5	Synechococcus_phage	2.9e-131	66.8
WP_172634458.1\|1693449_1694415_+	GDP-L-fucose synthase	D1LW79	Prochlorococcus_phage	4.9e-87	50.0
WP_013050759.1\|1694419_1695466_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	1.6e-99	53.7
WP_013050760.1\|1695468_1696341_+	glucose-1-phosphate thymidylyltransferase RfbA	A0A291LA53	Escherichia_phage	1.3e-107	65.3
WP_013050761.1\|1696337_1696745_+	WxcM-like domain-containing protein	NA	NA	NA	NA
WP_013050762.1\|1696734_1697184_+	N-acetyltransferase	NA	NA	NA	NA
WP_013050763.1\|1697180_1698284_+	DegT/DnrJ/EryC1/StrS family aminotransferase	E5ES42	Bathycoccus_sp._RCC1105_virus	1.5e-44	31.2

DBSCAN-SWA_2

2619642 : 2630856

uncultured_Caudovirales_phage(28.57%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013051560.1\|2619642_2620899_-	Bcr/CflA family multidrug efflux MFS transporter	S4TR35	Salmonella_phage	1.0e-12	21.9
WP_013051561.1\|2621028_2621931_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_013051562.1\|2622135_2622798_+	Bax inhibitor-1/YccA family protein	A0A2H4JFM9	uncultured_Caudovirales_phage	4.8e-33	41.3
WP_013051563.1\|2622940_2623330_+	sulfurtransferase complex subunit TusD	A0A2H4JA39	uncultured_Caudovirales_phage	2.5e-21	41.7
WP_013051564.1\|2623329_2623686_+	sulfurtransferase complex subunit TusC	NA	NA	NA	NA
WP_013051565.1\|2623685_2623967_+	sulfurtransferase complex subunit TusB	NA	NA	NA	NA
WP_172634462.1\|2623960_2624299_+	TusE/DsrC/DsvC family sulfur relay protein	NA	NA	NA	NA
WP_013051568.1\|2624638_2625925_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	3.1e-97	44.6
WP_013051569.1\|2625943_2626318_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	1.0e-08	36.2
WP_013051570.1\|2626310_2627642_-	replication-associated recombination protein A	G3MBE0	Bacillus_virus	2.0e-78	40.0
WP_013051571.1\|2627657_2628284_-	outer membrane lipoprotein chaperone LolA	NA	NA	NA	NA
WP_041420313.1\|2628354_2630856_-	DNA translocase FtsK 4TM domain-containing protein	S5VNE3	Mycobacterium_phage	8.3e-86	48.8

DBSCAN-SWA_3

3617700 : 3625317

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013052463.1\|3617700_3618183_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.0e-29	47.0
WP_013052464.1\|3618306_3619410_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	3.9e-64	38.6
WP_013052465.1\|3619519_3620182_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.8e-27	32.5
WP_013052466.1\|3620185_3621325_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	1.9e-53	35.7
WP_041420001.1\|3621375_3621825_-	transcriptional regulator NrdR	NA	NA	NA	NA
WP_013052468.1\|3621940_3623197_-	serine hydroxymethyltransferase	A0A219Y950	Aeromonas_phage	2.3e-92	53.4
WP_013052470.1\|3623649_3625317_+	energy-dependent translational throttle protein EttA	A0A1V0SKJ1	Klosneuvirus	1.0e-39	27.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014012

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection