CRISPRimmunity

Please click to download your results

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014169	Bifidobacterium longum subsp. longum JDM301, complete sequence	4 crisprs	c2c9_V-U4,cas3,WYL,DEDDh,casR	0	1	3	0

Results visualization

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_014169_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014169_1

321251-321336

Orphan

Consensus_repeat	Method
GACAGCTCCCGCCAGCGGGAGCACTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014169_1

>merge|NC_014169|1|321251-321336|CRISPRCasFinder
GACAGCTCCCGCCAGCGGGAGCACTTATTTGTAGGGAAATCCTCCAGTTCAAATTCGTTAGACAGCTCCCGCCAGCGGGAGCCTTT

>NC_014169|1|1|321251-321336|CRISPRCasFinder
GACAGCTCCCGCCAGCGGGAGCACTT	ATTTGTAGGGAAATCCTCCAGTTCAAATTCGTTA
GACAGCTCCCGCCAGCGGGAGCCTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014169.1\|WP_013140150.1\|314229_314859_+\|hypothetical-protein	unknown	unknown	unknown
NC_014169.1\|WP_013140152.1\|318089_319631_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NC_014169.1\|WP_013140156.1\|323265_324879_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235967
NC_014169.1\|WP_012576694.1\|312320_312602_+\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224848
NC_014169.1\|WP_007054758.1\|335698_336481_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_014169.1\|WP_013140159.1\|327972_330015_+\|hypothetical-protein	unknown	unknown	unknown
NC_014169.1\|WP_007051533.1\|316235_317204_-\|hypothetical-protein	unknown	unknown	unknown
NC_014169.1\|WP_003828150.1\|322525_322840_+\|DUF2469-domain-containing-protein	unknown	unknown	gnl\|CDD\|313765
NC_014169.1\|WP_013140149.1\|312808_314233_+\|DNA-recombination-protein-RmuC	unknown	unknown	gnl\|CDD\|376878
NC_014169.1\|WP_013140157.1\|325084_327154_+\|transcription-termination-factor-Rho	unknown	unknown	gnl\|CDD\|237171
NC_014169.1\|WP_013140153.1\|319655_321155_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NC_014169.1\|WP_007051520.1\|334953_335640_-\|endonuclease-III	unknown	unknown	gnl\|CDD\|223255
NC_014169.1\|WP_011068473.1\|317786_318086_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NC_014169.1\|WP_013140158.1\|327461_327851_+\|chorismate-mutase	unknown	unknown	gnl\|CDD\|181719
NC_014169.1\|WP_013140148.1\|309543_312210_-\|HAD-IC-family-P-type-ATPase	unknown	unknown	gnl\|CDD\|319774
NC_014169.1\|WP_013140151.1\|314952_315801_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349969
NC_014169.1\|WP_007056484.1\|308725_309460_+\|aquaporin-family-protein	unknown	unknown	gnl\|CDD\|223653
NC_014169.1\|WP_013140160.1\|330486_333222_-\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|380147
NC_014169.1\|WP_007051521.1\|333365_334892_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173859
NC_014169.1\|WP_013140155.1\|321450_322515_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112

Protein	Function_ID	Function_description	E-value
NC_014169.1\|WP_007056484.1\|308725_309460_+\|aquaporin-family-protein	gnl\|CDD\|223653	COG0580, GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism].	4.54303e-80
NC_014169.1\|WP_013140152.1\|318089_319631_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NC_014169.1\|WP_007051520.1\|334953_335640_-\|endonuclease-III	gnl\|CDD\|223255	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair].	2.51632e-96
NC_014169.1\|WP_012576694.1\|312320_312602_+\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|224848	COG1937, COG1937, Uncharacterized protein conserved in bacteria [Function unknown].	4.97655e-31
NC_014169.1\|WP_007054758.1\|335698_336481_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.13001e-44
NC_014169.1\|WP_013140156.1\|323265_324879_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|235967	PRK07208, PRK07208, hypothetical protein; Provisional.	0
NC_014169.1\|WP_013140149.1\|312808_314233_+\|DNA-recombination-protein-RmuC	gnl\|CDD\|376878	pfam02646, RmuC, RmuC family. This family contains several bacterial RmuC DNA recombination proteins. The function of the RMUC protein is unknown but it is suspected that it is either a structural protein that protects DNA against nuclease action, or is itself involved in DNA cleavage at the regions of DNA secondary structures.	1.71723e-106
NC_014169.1\|WP_003828150.1\|322525_322840_+\|DUF2469-domain-containing-protein	gnl\|CDD\|313765	pfam10611, DUF2469, Protein of unknown function (DUF2469). Member proteins often found in Actinomycetes clustered with signal peptidase and/or RNAse-HII.	1.30549e-58
NC_014169.1\|WP_013140153.1\|319655_321155_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NC_014169.1\|WP_011068473.1\|317786_318086_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	3.21183e-29
NC_014169.1\|WP_013140158.1\|327461_327851_+\|chorismate-mutase	gnl\|CDD\|181719	PRK09239, PRK09239, chorismate mutase; Provisional.	1.88746e-48
NC_014169.1\|WP_013140148.1\|309543_312210_-\|HAD-IC-family-P-type-ATPase	gnl\|CDD\|319774	cd02079, P-type_ATPase_HM, P-type heavy metal-transporting ATPase. Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	1.91249e-153
NC_014169.1\|WP_013140151.1\|314952_315801_+\|RNA-methyltransferase	gnl\|CDD\|349969	cd18096, SpoU-like, SAM-dependent rRNA or tRNA methylase related to SpoU. RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	2.10687e-42
NC_014169.1\|WP_013140157.1\|325084_327154_+\|transcription-termination-factor-Rho	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	0
NC_014169.1\|WP_013140160.1\|330486_333222_-\|valine--tRNA-ligase	gnl\|CDD\|380147	NF000540, alt_ValS, valine--tRNA ligase.	0
NC_014169.1\|WP_007051521.1\|333365_334892_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173859	cd08494, PBP2_NikA_DppA_OppA_like_6, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NC_014169.1\|WP_013140155.1\|321450_322515_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	6.90082e-13

>NC_014169.1|WP_013140153.1|319655_321155_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MAEKLMKYADATKKYDVVFGLETHVELSTNTKLFCPAHIEFGGEPNTELTPVSLGLPGSLPVINKTAVDYAIKLGLALHCEIAEWSQFARKNYFYPDMPRDYQISQYDKPTNGNGYLDVELEDGTVFRVPIERAHIEDDAGKNTHVGGADGRIEGADHSLVDYNRAGVPLIEIVTKPIEGAGDRAPEIAGAYVRAIRDIVRALNISHARMEQGNMRADVNVSLRPSPDAPYGTRSETKNVNSFRGIEKTIQYEIRRQAARLDDGKEILQETRHWDEATQTTAGGRLKSDADDYRYFPDPDLVMLHITKEHIEEMKAQMPEMPRERRNRLKSEWGLSDLQMRDILNADALDLIEETVKAGAKAAGARKWWLGELSREANAKGMSLEELPITPADVAEVEKLIASGKLNDKLAKQTVEGVLKGEGTPDEVVKKHDYKIVEDNGAIEAAVDAAFESNPDVVEKLKSGNMKPMGVIIGAVMKATRGQADAKAVTKVVMGKIKG
>NC_014169.1|WP_013140152.1|318089_319631_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MSNETATLVKLSAAEQAAAIKKGDVTSRELVEAHLKVIEAAEPSIKAFLKVSGDVALEQADAFDAKSAEDKAALPELAGVPIAIKDMIVTKGIETTAASKILEGWVPPYDATVIEKLKAAGMPILGKTNLDEFAQGSSTEHSAYQTTHNPWDTERVPGGSGGGSASAVAAFEAPIALGTDTGGSIRQPGALTGTVGVKPTYGGVSRFGAIAMASSLDQIGPVSRTVLDSALLQEIIGGHDKRDSTSIPEGPRPMVAAAREGAKRDLKGMKVGLIKELGGDGFQPGVEARFNEAVDKLKEMGAEVVEVSVPHIGYSLGAYYIIMPSEVSSNLARYDGMRYGLRVMPPTGVPQTAANMMAYTREAGFGDEVKRRIILGTYALSAGYYDAWYGSAQKVRTLIIRDFHNAFEKADVLVAPTSPSTAFKFGEKMDDPLAMYMNDIATIPANLAGVPAMSIPAGLSDDGLPVGFQFIAPQQRDEVMYKPAAALEAALEDSWNGPIWNDLKTPWLDGLGK
>NC_014169.1|WP_011068473.1|317786_318086_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MPTFSREEIVHLGDLARIALTDEEITRLQGELNVIADSINKVQEVASDDVPPTANPVPLEAYLRPDVAETPLTQEEALAGGPKTEAGMFVAPRILGSEE
>NC_014169.1|WP_007051533.1|316235_317204_-|hypothetical-protein
MKHHKAVDILITKAEATQQCAYGTTKAHRSALARRVQARELKRVFPNMYAASEYWDSLQPDERIRHIARTLHNRHPDWVFAGVTAAAIHDFEHQWHLHAGTITLATTSRGPNASSAKVKRIFTSSSTPEYANGLPVTSKARTVVDCGLSVDFRFALPIIDSALRNGVAITDILNVCSTMRRDCTPIFRLLHYANPASENGGESLGRGTIIAGGLLAPELQQNITDPQTGALYRVDFLWRLPENRLIVGEFDGYEKYVNPDMNDRKGVRGAVQAEKERETALYRAKVDTIVRFTYEEVMQQHPLLNKLRAAGIPHAGTVMGAG
>NC_014169.1|WP_013140151.1|314952_315801_+|RNA-methyltransferase
MHAPNQISLAAKASGEPEFREIGLGPWSETHPGEPRPDDPTSPNYDGRFDSVLLNDGDRRNVLDRYRYWTVAAIKADLDARGRHDFEVAVENWTHDFNIGSMVRTANAFQAKRVHIVGPHKWNRKGALMTELYQHVEHHPSIAELVESWHHRIAGEIAYERAKAGAAAIHAHDVAVDGDNKHLHELLAEIDACDARIKELQAARVIALDIIPGAVPMETYTFPKRCLLLFGAEGPGLSEKALELADDVVYISQFGSVRSINAGAAAAVAMHAWIAQHAVSGV
>NC_014169.1|WP_013140150.1|314229_314859_+|hypothetical-protein
MTESGFRPTGTPDLAVAKSHNDFAVLEPREQLATLLREHVVGRPFSELAAVTFDHRAATVMGHVLIDALEDAGYSVDDFDAVGALTAASVPMVSAMIQAAASRGEDLDGFVMDFVYPSIKGPSIEGRRVVLLDAWLSEKSYVQTSSLVTLRNGNELSLDFGIVEQLDAKVVAIASLVGGGAKDINVVNPSTGDEQTLPFIQVFDESELR
>NC_014169.1|WP_013140149.1|312808_314233_+|DNA-recombination-protein-RmuC
MFEQIGTVVIVIVVLVVGAGLGLFAGFVLGRHKGQEMARGVKSEELEETKTSLENARFENAELSARNAAAQAQIEGVNQQLAFAKSQLAQAQQAEQIRIQQERERAAAEAERKRQADAQAAEAKRAEQEARLKEQSKVLEALAPVAKNLDTLQNKVTQIEEGRKREMGALGAQLKGLNDQQARLDKETSSLSAALRNNKVRGAWGEAQLKNIVESAGLLEHVDFDIQVVVTDADGRTLRPDMIVHLPGGKTIPIDAKVPYADYQRACEIPDTASPEDIARRDDLLRAHAKALREHVRALGEKAYWNAFDVAPDFVVAFIPNEALLQAALEADPTLMDDAFSRKVALTSPVTLWAVLKSVAYAWQQQSLTDDAKQLFDLSRELYERFSTLGDYAIKLGTQITKTVSAYNKFASSLERRVLPTARKLQKIEPTKIIEEVPIIESDKGNVSELSAPEVVPADEGDTHLTASGDSLES
>NC_014169.1|WP_012576694.1|312320_312602_+|metal-sensitive-transcriptional-regulator
MHGYDEDKAKVIARLRRIEGQVRAITQMVEDDKYCIDILTQISASNSALKSVALLLLDDHLNHCVRQASVQGGEVADEKLAEASAAIARLVKS
>NC_014169.1|WP_013140148.1|309543_312210_-|HAD-IC-family-P-type-ATPase
MEFSIFSTATALIVAAALTWLVLRFFFGTQKATAGAMDASGERQSATITVKGGYSPAVVSMRAGTPITLVFDRQETGECTSHVVFADLGLDAMLPGNATTDVELPALPPGEYPFACGMNMVHGMLKVEGEDGSDENTPLPHPDASYTAPTAVDAAEGERREAAERASEIKALTKLVIVAAVLTLPAFAVTMLHMANPALVPHWMVNPWLQAILITPVMFYCGCPIHTVGFPALAHRSPDMNSLVSLGTSAAYLYSLVTCIAPWVFPEGSREPYFESVGVVITLVLVGRLLETKAREGTGKAVQSLIKLSPRTAHKLNATSADNVDGIEWRNPAYFTDTDIDAIATGDLLVVKNGERVPTDGIIVAGEAHIDESMITGESKPVSKTVGDPVTGATVLLKGDCVMRATQVGADTVLSQIAAMVARAQATKAPVQQLADKIARYFVPAVMIIAIWTFAIWVSLGPVPQLAHALVTAVSVLIIACPCALGLATPLSVTVSLGLGATNGVLVTSAKALEQARRIGTVVFDKTGTITRGVVDAAADWDKPSYEQDTVKEGSREAIAALRARGIRTVMLSGDKAEVAGRIAREVGIDTVICEIKPDGKAYWIAKLQRERDEAAVKSADGTSRTAAQSRTLIAMVGDGINDAPALAQADLGIAIGTGTDVAMQSADVTLMSGDLRGVIKTINLSNATMRNIRENLGWAFGYNVIGIPVAAGVLYPFTGWLLSPMIAGLAMALSSVCLVLNANRLHGANINVGAADGPAGSGSSTADVESAGSAESANAANITGSATSNAPHEPTVIIDDRTTLNQTNHVSDQSNNPTNKENTMDTGMHMHHTAPADGETATDPVCGMTVAVNADAITREYEGKSYYFCGEHCATNFMKAPQVFLEQ
>NC_014169.1|WP_007056484.1|308725_309460_+|aquaporin-family-protein
MDYPLFTKLAAEFFGTAILMIFGNGSVANVELKNTKGHHAGWLNIAMGYGFGVMFPVLMFGSVSGAHINPAMTIAQAVNGLFPWSDVLPYIVAQLLGALLGQLIVYITYYPHYKETEDAEAILGTFCTTDADNQKANYFLNEMFGTLVLVFGALCCLSLAWGKQDYAAASIVVGFIVWGLVTSMGGPTGPGLNPARDLMPRLLHAILPIPHKGSSRWGEAWIPVVAPIVGAIIGAWLFVFFFAN
>NC_014169.1|WP_013140155.1|321450_322515_+|GNAT-family-N-acetyltransferase
MTATNETLSMATEVQLKRDLPQNIVIPPIRGEMVHLRPATAEDLARLDELDAFYGASKITGKDAVTERAIVHTWVRRSQAWEAGQAPAESGVGDPESRRTIAWAVLTDADHDDDGQLDAASTDNVIGMIFLIDIDGWSKSARIQIILGREYRGRGYSRDAMPRVMTYGFAPEPAGLGMHRIWVSVPEKNSRSISVYQSLGFVPSGTSRDALWDVENNKYQDLIVMDTLVDEYDPIRSLDAFGMHLIEDNPGVKEALSAREHSIAIQQNKPEPEPAQRGEAAAVTTSDVQSQAQTPAAAQPVEPQAGHHDDTQKNTRHSLEEESNWPYGQAERKPSKEAWWRTLGRGRKRDTESE
>NC_014169.1|WP_003828150.1|322525_322840_+|DUF2469-domain-containing-protein
MSAEDLDNYETDAELALYREYRDVIKLFTYVVETERRFYLANKVDFNVRSAGQDVYFDVQLTDAWVWDVYRSSRFVKSVRIVTFKDVNVEEVQKTDIDIPDDIH
>NC_014169.1|WP_013140156.1|323265_324879_+|NAD(P)/FAD-dependent-oxidoreductase
MTDKQSVVIIGGGPAGLTAAWELIKDGGADKYDVTVLEGTREFGGISRTVKYNGNRMDIGGHRFFSKDERIMDWWKTVLPLQGAPSYDDKKLGRDHDMEPGGPDPETEDKVMLKRHRVSRIFWNRHFFDYPISLSPNTLKAMGFKLTMVAGFSYLKSMFHKLPEDNLENFYINRFGRKLYSMFFEGYTEKLWGRHPSQISADWGAQRVKGLSIMGVLKNAFQKLSPRKRSNAEVETSLIEEFWYPKYGPGQLWETVESNCEAAGVKVLTDARVVEVRQTDGAVSSVVYEDSEGNRTELSGDQFISSMPVKDLVNAIDAAGDDPEAADSKPAPADMTEVANGLPYRDFVTVGLLVKHLKLKNTTNIPTLGNPPIVPDCWIYVQDPGYKVGRLQIFNNWSPYLVKNVDDTVWVGLEYFCEEGDSFWNMSEEDVTKFAISELTRMRVINGPDEVIDSHRERVKKAYPAYFDTYEHMDELIEYLDGFGNLYCVGRNGQHRYNNMDHSMATAMEAVGNIKTGKTSKKNVWSVNTEKSYHEEK
>NC_014169.1|WP_013140157.1|325084_327154_+|transcription-termination-factor-Rho
MANSQNLEDMKLPELKELAKQMGLRGTSTMRKPELLATLQAARNGGEPPAGVTVRAPKAAKTAKVVKAPQSDAAEANTTDNADVATQSPAPAPAATEPQLDLPLPVADDAKKDETEPRRTRRKAADDAASEPRAARHRRDDDQSDFARRKPRKKADEAGDLLATLDLGDAAPTERRRERHEDVEVPLIRRVRDDEDEQPRRRRRTAENSEETVRDLDDILATLPTQKHEETSEDGEQNDDHEFVRRNRRDRSDRNDRDNRNDRNDRRNRRMRGRDRDNADDDRRYDDRDNRSDRNDRDSRREEPQEDLVPVAGIVDVLDSYAFVRTSGYLPGPNDVYVSMGQVKKYGLRKGDAVHGSIRAPREGDRRNQRQKFVPLQAIDSINGQSVEEALNRPQFSKLTPLYPQERLKQETAPNKLTGRIMDIVSPIGKGQRGLIVSPPKAGKTITLQNIANSIAANNPEVHLMVVLVDERPEEVTDMERTVQGEVISSTFDRPASDHTTVAELAIERAKRLVELGQDVVVLLDSMTRLARAYNIAAPASGRILSGGVDAQALYPPKKFFGAARNIENGGSLTIISSALVETGSKMDEVIFEEFKGTGNMELRLSRELADKRLFPAIDINASGTRREELITNPQELPIIYRLRRLLGGMEPEQAYQTLVPRLKKTATNRDFLAAIVQQANTGNAVNGN
>NC_014169.1|WP_013140158.1|327461_327851_+|chorismate-mutase
MSETSSGWQRTTIDSAQAAAHPETAQAVARIKALRQTIDNIDSAAIALLAERFKATSQVGVLKANAGFAPEDTKREDYQIERLHRIAIDAGLDPEIAEMYREFVVTEAKKRHQRIADAGGDPGVLDVFA
>NC_014169.1|WP_013140159.1|327972_330015_+|hypothetical-protein
MRCGTALVSCALCVASILGGAWMSRPTPVDYGPVLATASDMYAVTDAEGEPVRWYVVGKGGAGNGASADSGNSGSTDTDSANSNSGTSKVSRIPASAATLPWKVSVTYSLDGPNVEANEVAGASGLIGVYIDIKPQTKEANRTIPVVAFTVPTQVADDVSADNSITVTTQGSNTVVAAAGKAATGLEFSCYMNAKDFSMSSVALAVLPSNSSSPVVGANPDAANAAAQPAADTDVAQLVASAAILVDSLTDAGSGEHQQLIEQLQTLRDNERALDKSVVAERETAHKRTFEDYMAAYVGSYTTHLSGSIGTSTQLPALMGTAGELSGDTPLAQAVLDLANAVNNVSAAHQHAGAVDALDEVIRRIQQQGTTGLVDDLTAEASEEATRGSKQYADGQSQLSAAMIPYSMKYTDVYTANLSALTGGTSSGATAYESQAIAETNGSDELADAQSKVDAAMSTLATASEHTGKATALRQIVLRFSDQFEGVASSASGSDGDGSSGDVSSGPVTEAQALTGLVDSQSQSFYGKTRAAQAKRKADAARKQAKAAQQQQSQHSKASLVDDTMSMSAGDVMNYAGGLTSAIGGGGKSDSSKSDGSGTNDSAKSSDTGDSGNNLDTAPVLFGFGTGGTLLKHDMSALINETVEISDAGTLLAQAVAQLDSPNTQQKTAETRYLIVIPTV
>NC_014169.1|WP_013140160.1|330486_333222_-|valine--tRNA-ligase
MTEGKSIINANLTPLPDKVGVDGLEDKWRTVWDEDGTYKFRNTRDRKAVYSIDTPPPTVSGSLHVGHVFSYTHTDVIARYKRMRGYDVFYPMGWDDNGLPTERRVQNYYGVRVDVSLPYDPDFKPPFEGTDGKKIDAKDQVPISRKNFIELCERLTAQDEKLFEALWRKLGLSIDWSQTYHTIGQHPQRVAQKAFLRNLARGEAYQQDAPGLWDVTFQTAVAQAELESREYPGFYHKVAFRFEDGTPIYIETTRPELLAACTSLIANPNDERYKQYFGQYVYSPLFKVKVPILAHPAAEMDKGAGIAMCCTFGDVTDVEWWRDLKLPTRPIIQRNGRIVMDTPDWIEDPAGREVFAETAGKTTFSARKIIVDKLRESGDLDGEPTPTKRMTNFYEKGDKPLEIVTSRQWYLKNGGTDAKLNAELIERGKELEFHPDFMRVRYENWVHGLNGDWLISRQRFFGVPFPLWYPVNASGEPDYDHPITPSEDRLPIDPTIDVPEGYDESQRDVPGGFTAEKDIMDTWATSSLTPQIVTHWAEPDEASKALFASTFPMDLRPQGQDIIRTWLFSTVDRAHLENKCLPWAHATLSGWILDPDHKKMSKSKGNVVVPNEPIEKFGADAVRYWAAAARLGLDATYDIGQMKIGRRLAIKLLNATKFALAIGREDENHHVGAAAEAAWNPADVTEPLDRAAMAKLALVVRQATEALESYEHSKALEVIESYFWQFCDDYIELVKNRAYGTPDEQGHVPSEKAVKSARTALGLGLDAFARLLAPYLPYATEEVWSWMHAGSGSVHRAAWPVVDPYVEAATGASPELLTWAGKAVEQLRKIKSEAKVSMKTPILSVALSAASEGVNAIHAALGDIAQAGRVVGKFDLVAKHAEESAAEDAPETEVAVEASELGEPPAKKPKH
>NC_014169.1|WP_007051521.1|333365_334892_-|ABC-transporter-substrate-binding-protein
MQHSKRDNTWSKWGIFLGVAVALGALVVVGWTFMQNRFQPGSSLDADVTIGIDDMPQSLDIRSDSSAAAERLLVDNVYETLVTVDQDNKLQPGLATSWKTSDDGLTVTLTLQSGVTFSNGHTLDASDAVWSLQQNVTNKVADVDELGDLASVANPNATTVVITLAKPNPTLLRALSGRLGIVYDSESSSADYQRKAIGSGPFTVADFQPGHSLKLARSDTYHGTKAASNVVEFMQYSDADALSKALTDGSLDMAAPVSASTATGLNGKDGLTVKEGATTDKVLLAYNNGTDSLLSDEQARKAFRYQIDAAGIASAQPDAAGALGGPISLLEPGYEDLTGLYPHDENQAGQMFSYFGAQYLTTVNLVVPEEYRSLAETIKQQIERQPRPTVNLEVLSDEDYAKRIKDGKWELTVMSMDGTDDAGIFADPDSMFHYDHTEAQQAYADARAATNDADYEARMKAYARLISEDAASDWLYTRKCFTVASTKVSGYPTSMINRRMPLAGLTVK
>NC_014169.1|WP_007051520.1|334953_335640_-|endonuclease-III
MRETKSARLTRMHDEYDILRQVIPAPACALHFSNPLELLIATVLSAQTTDKRVNTVTPELFATYPTARDLAAANPAQVEDIIHPLGFYRSKTQHLIGLATALDERFGGVVPRTMDELTSLPGVGRKTANVVLGNAFDIPGFPVDTHVMRVTGRLRWRSDWRSAHPDPVKIEKEITSCFPPEEWTNLSHRLILFGRATCHARTPDCANCPLSDTCPSYAPPAGKSTSKR
>NC_014169.1|WP_007054758.1|335698_336481_-|response-regulator-transcription-factor
MTFASDPATVLPSLALLSHRVRVLPMDAASLVKMPENTILFLDARDDLATAKTLCRLIHASGLSTPIVLVLTEGGFTVVNSQWGIADVVVATASPAEVEGRLRLVSERGNAPAAAAAGSPAESTTTVEDGQIRSGDLIVDTNGYTASLHGRPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHIRRLRAKLGGEYEHLIGTVRNVGYRFDPPETDKETAAAQQAAKASSAAIDTDDDTPDLNTVA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_014169_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014169_2

1589818-1589973

Orphan

Consensus_repeat	Method
AGCGTCGGCCTCGGAGCGGGTACG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_014169_2

>merge|NC_014169|2|1589818-1589973|CRISPRCasFinder
TGCGTCGGCCTCAGAACGGGTGTTCTGGGAGTAGGTCTCGGCATCCGCGTGAATCTGGTCACGGTAAGCGTCGGCCTCGGAGCGGGTACGATCCGAATAGGTGTCGGCGTCGGAACGAGTACGAGTGGAGTAGTCGTCGGCCTCGGAGCGGGTACG

>NC_014169|2|2|1589818-1589973|CRISPRCasFinder
TGCGTCGGCCTCAGAACGGGTGTT	CTGGGAGTAGGTCTCGGCATCCGCGTGAATCTGGTCACGGTA
AGCGTCGGCCTCGGAGCGGGTACG	ATCCGAATAGGTGTCGGCGTCGGAACGAGTACGAGTGGAGTA
GTCGTCGGCCTCGGAGCGGGTACG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014169.1\|WP_038425973.1\|1569472_1570870_-\|histidinol-dehydrogenase	unknown	unknown	gnl\|CDD\|234853
NC_014169.1\|WP_013141004.1\|1570982_1572449_-\|gluconate-kinase	unknown	unknown	gnl\|CDD\|198373
NC_014169.1\|WP_003830347.1\|1602545_1602923_+\|thiamine-binding-protein	unknown	unknown	gnl\|CDD\|376658
NC_014169.1\|WP_013141016.1\|1593218_1594463_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NC_014169.1\|WP_038425976.1\|1587937_1588900_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_014169.1\|WP_013141007.1\|1580304_1582182_-\|oleate-hydratase	unknown	unknown	gnl\|CDD\|237575
NC_014169.1\|WP_013141005.1\|1572757_1573585_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381352
NC_014169.1\|WP_013141013.1\|1590988_1591291_-\|YggT-family-protein	unknown	unknown	gnl\|CDD\|376765
NC_014169.1\|WP_013141009.1\|1582910_1586468_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|235554
NC_014169.1\|WP_013141020.1\|1597547_1600301_+\|phosphomethylpyrimidine-synthase-ThiC	unknown	unknown	gnl\|CDD\|236451
NC_014169.1\|WP_013141021.1\|1600337_1601546_-\|26S-protease-regulatory-subunit	unknown	unknown	gnl\|CDD\|224143
NC_014169.1\|WP_012577184.1\|1588899_1589448_-\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|184816
NC_014169.1\|WP_038425975.1\|1586502_1587303_-\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NC_014169.1\|WP_032684064.1\|1591904_1593107_-\|cell-division-protein-FtsZ	unknown	unknown	gnl\|CDD\|236468
NC_014169.1\|WP_013141019.1\|1596520_1597465_+\|hydroxyethylthiazole-kinase	unknown	unknown	gnl\|CDD\|238575
NC_014169.1\|WP_013141006.1\|1579708_1580209_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|223532
NC_014169.1\|WP_038425974.1\|1582387_1582798_-\|DUF4186-domain-containing-protein	unknown	unknown	gnl\|CDD\|372733
NC_014169.1\|WP_013141017.1\|1594613_1596086_-\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235240
NC_014169.1\|WP_013141022.1\|1601672_1602482_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|369938
NC_014169.1\|WP_013141014.1\|1591412_1591892_-\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|377370

Protein	Function_ID	Function_description	E-value
NC_014169.1\|WP_038425973.1\|1569472_1570870_-\|histidinol-dehydrogenase	gnl\|CDD\|234853	PRK00877, hisD, bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Reviewed.	0
NC_014169.1\|WP_013141004.1\|1570982_1572449_-\|gluconate-kinase	gnl\|CDD\|198373	cd07805, FGGY_XK_like_2, uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases. This subgroup is composed of uncharacterized proteins with similarity to bacterial D-Xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17), which catalyze the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. The presence of Mg2+ or Mn2+ is required for catalytic activity. D-XK exists as a dimer with an active site that lies at the interface between the N- and C-terminal domains. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	1.92275e-138
NC_014169.1\|WP_003830347.1\|1602545_1602923_+\|thiamine-binding-protein	gnl\|CDD\|376658	pfam01910, Thiamine_BP, Thiamine-binding protein. The crystal structure of two of these members shows that this domain has a ferredoxin like fold and is likely to exists as at least homodimers. Sulphate ions are are located at the dimer interfaces, which are thought to confer additional stability. Although the function of this domain remains to be identified, its structure suggests a role in protein-protein interactions possibly regulated by the binding of small-molecule ligands. Solution of the structure of the hyperthermophilic anaerobic Thermotoga maritima sequence, UniProtKB:Q9WYV6, shows that this has a beta-alpha-beta-beta-alpha-beta ferredoxin-like fold and assembles as a homotetramer. It was possible to identify a pocket in each monmer that bound an unidentified ligand. It was also found that it bound charged thiamine though not hydroxymethyl pyrimidine. It is proposed that it is transporting charged thiamine around the cytoplasm. Under oxidative conditions this bacterium is under stress, and the transcriiptional unit within which this protein is expressed is up-regulated in these conditions, suggesting that the chelation of cytoplasmic thaimine is part of the response mechanism to such oxidatvie stress, which is mediated by this family.	4.82714e-25
NC_014169.1\|WP_013141016.1\|1593218_1594463_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	8.06669e-119
NC_014169.1\|WP_038425976.1\|1587937_1588900_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.77191e-94
NC_014169.1\|WP_013141007.1\|1580304_1582182_-\|oleate-hydratase	gnl\|CDD\|237575	PRK13977, PRK13977, myosin-cross-reactive antigen; Provisional.	0
NC_014169.1\|WP_013141005.1\|1572757_1573585_+\|aldo/keto-reductase	gnl\|CDD\|381352	cd19126, AKR_AKR5A_5G, AKR5A and AKR5G families of aldo-keto reductase (AKR). The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.	4.05249e-163
NC_014169.1\|WP_013141013.1\|1590988_1591291_-\|YggT-family-protein	gnl\|CDD\|376765	pfam02325, YGGT, YGGT family. This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown.	6.76063e-05
NC_014169.1\|WP_013141009.1\|1582910_1586468_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|235554	PRK05673, dnaE, DNA polymerase III subunit alpha; Validated.	0
NC_014169.1\|WP_013141020.1\|1597547_1600301_+\|phosphomethylpyrimidine-synthase-ThiC	gnl\|CDD\|236451	PRK09284, PRK09284, thiamine biosynthesis protein ThiC; Provisional.	0
NC_014169.1\|WP_013141021.1\|1600337_1601546_-\|26S-protease-regulatory-subunit	gnl\|CDD\|224143	COG1222, RPT1, ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones].	2.94637e-75
NC_014169.1\|WP_012577184.1\|1588899_1589448_-\|signal-peptidase-II	gnl\|CDD\|184816	PRK14771, PRK14771, lipoprotein signal peptidase; Provisional.	3.91022e-102
NC_014169.1\|WP_038425975.1\|1586502_1587303_-\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	1.04703e-22
NC_014169.1\|WP_032684064.1\|1591904_1593107_-\|cell-division-protein-FtsZ	gnl\|CDD\|236468	PRK09330, PRK09330, cell division protein FtsZ; Validated.	0
NC_014169.1\|WP_013141019.1\|1596520_1597465_+\|hydroxyethylthiazole-kinase	gnl\|CDD\|238575	cd01170, THZ_kinase, 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine and 1-deoxy-D-xylulose-5-phosphate.	2.7954e-83
NC_014169.1\|WP_013141006.1\|1579708_1580209_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|223532	COG0456, RimI, Acetyltransferases [General function prediction only].	3.3936e-08
NC_014169.1\|WP_038425974.1\|1582387_1582798_-\|DUF4186-domain-containing-protein	gnl\|CDD\|372733	pfam13811, DUF4186, Domain of unknown function (DUF4186).	2.35157e-66
NC_014169.1\|WP_013141017.1\|1594613_1596086_-\|glycine--tRNA-ligase	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NC_014169.1\|WP_013141022.1\|1601672_1602482_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|369938	pfam08543, Phos_pyr_kin, Phosphomethylpyrimidine kinase. This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes.	8.86456e-125
NC_014169.1\|WP_013141014.1\|1591412_1591892_-\|cell-division-protein-SepF	gnl\|CDD\|377370	pfam04472, SepF, Cell division protein SepF. SepF accumulates at the cell division site in an FtsZ-dependent manner and is required for proper septum formation. Mutants are viable but the formation of the septum is much slower and occurs with a very abnormal morphology. This family also includes archaeal related proteins of unknown function.	9.53527e-26

>NC_014169.1|WP_012577184.1|1588899_1589448_-|signal-peptidase-II
MTNQQGRLRTRVAVFACVAAAALIVDQLTKAWAMAALSNGQTIRVIPGLLSFTLVRNPGASLGMGSGATWVISLLAVVACVALAVAGVRTISMKWSVALSFAFAGALGNLIDRVMYADGFLNGKVVDFLNYGWSVGNVADIYLVVAGVVLVILILMGEPFSHKDLIEQSDESLQSEPEADAK
>NC_014169.1|WP_038425976.1|1587937_1588900_-|RluA-family-pseudouridine-synthase
MSRMVPAPDALVGKRFDVAVAKMLGISRSKAADLVDSGQARVLGREVARSSTLQAGETVEFDLAEEQAGPEPIATDMAVVYEDDDVVVVDKPVGVAAHASVGWTGPTVLGSLRDRGVHIASYGAAGREGIVSRLDVGTSGLMLVCKSDLAYTEMRRQFAEHEVKKTYHALVQGGLKENKATIEAPIGRAKVSDFRFCVTPAGKPAVTHWDVLERFGHEATLVSVNLETGRTHQIRVHFSSIGHPLCGDPMYGANPVLSEALGLDRQWLHAMKLEFRHPRTRVWTTVRSQYPADLAAALDAMRARHIEPAEPAEYAEVLVD
>NC_014169.1|WP_038425975.1|1586502_1587303_-|YihY/virulence-factor-BrkB-family-protein
MLDRYVSRRGPLLANGLAYGLLFAFFAGVWIAVSVFGLIMVGNIDWQQMLIDAVREVIPGVADSFLTSSALNTMSSTLTWTGLATLAMFWWTVTGWMNSLRHAVRSMFDDCGDELNIVVARLRDTLAAIAIAILFILSTAAGTVSGGMVRRVLQWSGIASSSLPGILLLELTGFCTGVALNFALFMLLLRVVAHIKAGRFTLIGASSGSLTVSVMQLLGARLLTGASRNPLLAPFAALIGALVWFNLVAQVIMLCAALIAECRREC
>NC_014169.1|WP_013141009.1|1582910_1586468_-|DNA-polymerase-III-subunit-alpha
MADYGNNFVQLHNHTHYSLLDGASKIPDLAKRAAELGMPAVGITDHGNMHGAYEMYTNCVANGVKPIIGIEAYVTPETARQDKSRVHWGTEAQRRDDVSGGGLITHLTMWAENDEGLVNLIKASSVANLEGRVMRYPRMDKEVLATYSKGVIASSGCPSGIIQTRLRLGQFDEALRAAGEFQDIFGKDNFFIELMDHGLPIETQVTGDLLTIAKKLNAPLLATNDSHYVHAEDAQAQDAMLCINSGSRLDDPDRFKFDGTGYYIKTAEEMRELFKDHPDACDNTLAIAERCNVMFDDHEDGAFMPKFPCPEGWDETSLFLKKVEEGLEKRYDGNPPLDVLKQADYECGVICQMQFCGYFLVVADYIQWAKDHGIMVGPGRGSAAGAMVAYSMGITELDPLKHGLIFERFLNPERVSLPDIDVDFDPEGRARVIEYCGEKYGTDKVAQCVIYGTIKTKQALKDSARIMGYEFSVGEKVTKALPPAATGGKDISLHDIFDPTAKRYAEAREFRELYDSDPDAKRITEEAKGIEGLIRQTGVHACATIMGSAPITDTSPLLERTDGTITTTFEYHTCETLGLVKMDFLGLSNLTIIHDTLKNIEANGKPAIDYTKIPLDDAETYKLMSRGDTLGVFQLDSDGMRSLLKTLKPDNFNDISALIALYRPGPMSMDSHTNYAKRKNGLQKITPIHPELEEPLKQVLDETYGLIIYQEQVQSAARILAGYSLGKADVLRRAMGKKKPEVLAKEKVPFFAGMKEHGYSEEASQAVWDILVPFSGYAFNKAHSAAYGLISYWTAYLKTHYPVEFMAALLQGAATNKDKTALYLGEARRMGIQVLSPDVNESVYEYSAVGDVVRFGLGAIRNVGDKAVADIIAEREGPRGKFVNFMDFIRRVPLTALNRRLVESLIKAGAFDSIDPNRRALFTVHEAAIDSVVSLKRKQAEGQFDLFSDAEDGGAEAMGDASVTVPDLEEWDKKTKLNFEREMLGLYVSDHPLSGMQSILASLREMSIAHLVDRAKTMGEGQQVTLAGLVTNVDRRVSKKGNPWAIVTIEDMESSIQCMFFGKVYEAAAAELAVDAIVQIRGQVELRDETVSLRATEMQIPTLEAEDERPLVITLPPVALERQRMMQLGQVLANHPGYCEVHLAVLDEKGNAQVLTFGDRFRVKRDTSLFAEIKILFGPSCLPAA
>NC_014169.1|WP_038425974.1|1582387_1582798_-|DUF4186-domain-containing-protein
MGMEMADTGNNDDERQWIAAMLERLSHSQFRAKFALTDKDRAYARTKGKATIDRHAREMLRDRIGAAEPKNDGRQTPWRGHPVFTAQHATATCCRGCIEKWHHLPKGRELTEAEVNRLADLVMAWIERDLINHPVR
>NC_014169.1|WP_013141007.1|1580304_1582182_-|oleate-hydratase
MYYSSGNYEAFARPKKPADVDNKHAYIIGTGLAALSAACYLVRDGQMPGENIHILEKDPVPGGACDGLDIPGLGYVMRGGREMDNHFEVMWDLFRSIPSIETEGVSVLDEYYWLNKEDPNYSLCRATKDLGKDAGLKGKFGLSDKASMEIMKLFFTPDEDLYDKPITDFFDDEVLNSNFWLYWRTMFAFENWHSALEMKLYIKRYIHHIGGLPDFSALRFTRYNQYESMILPMVKYLESHGVEFRYNTKVENVEFAIGGGAGPKREHTGVGQDTIQKIQATSGFFKRNPASTPTKKLAVRIDVDHEGDKSSIDLTENDLVFITNGGCVENSTMGSQNSPAAWNPDLKPGGGWDMWKRIADQDPSFGHPEKFCSDPNATKWMSATITTLDGEIPPYIQKICKRDPFSGKVVTGGIVTVQDSNWLMSWTLNRQQQFRDQPKDQLCVWVYGLFPDKPGNYVKKPMTECTGEEICEEWLYHMGVPTDKIEALAKHHANTVPVMMPYITAFFMPRAAGDRPDVVPDGAVNFAFLGQFAETPRDTIFTTEYSMRTGMEAVYTLLGVDRGVPEVWGSVYDVRNLLNATVKLRDGAPVTDMKLNFIEKAVVKKVLKKLDGTDIATLLREYHVI
>NC_014169.1|WP_013141006.1|1579708_1580209_-|GNAT-family-N-acetyltransferase
MTDSDPQLIRHATIDDLDALAAMEFECFPAAEAADRSSLRARIETYPECFWLLIDGEIVMAFINGFVTDRRDLTDDMYEDAAQHNPQGDWQMIFGVDTAPKYQHRGCASTLMRKVIEDTRAAGRKGLVLTCKDRLVGFYARFGYEDEGISDSTHGDVVWHQMRLTF
>NC_014169.1|WP_013141005.1|1572757_1573585_+|aldo/keto-reductase
MAIQSTIMLNNGTVIPQVGLGVFQTPDGDTTVNAVQTALENGYRHIDTAMIYRNEASVGEGIRRAGVPRSDFFLTTKLWNDDIRARHGKDAFQESLDRLGVDYVDLYLIHWPADGWQQAWDDLQEIYASGRAKAIGVSNFQKHHIDELLTHSDMVPAVDQIESSPQFTNQELIGQLRAKGIATEAWSPLGGTGGNLLSNPVLAEISAKYGKSPAQVVIRWHIQRGIVVLPKSTHAERIKQNFEVFDFNLSVDDMTAISAINTGKRNGADPDNFNF
>NC_014169.1|WP_013141004.1|1570982_1572449_-|gluconate-kinase
MAEEYVAAFDAGTTALKGALVDRQGRIVASASSELNLIINGDYREQSPDQWWQAFCSASRHMIEQARQSESEFNVTRIRGIIFSGQMQDVIALNGELNPVRNAILYSDGRAEEQAKQLAKTYQGGVERFLNTVGNRLEGCLPLPKLMWLREHEPETYARIRHVLISSKDYLIAQLTGECVGDVAACSTAGAMNIRNGQWDAELCEAAGIDMAMLPHLHNPQDNIGTVTESAAQRTGFSAGTAVYAGIGDAGATTLASGVSRPGQYNINIGTSGWIATVSPEPFTGKPGAANLAFGVEEVFVNAVPFLNAGDVHKWVTGVFADGDYAEAHQLIETSKPGSNGVMCLPYLVGERFPVMNPNIRGAYVGLDPDTTKADMMRAALEGVAFSIRQGMESFDAKPSEISLIGGGARENAWCQILADVLEHPIEVFANADILPAVAMASLVFNVPDLLQSVCECTVYQPNPDTARTYADAYRRFLSLYPMLRTMD
>NC_014169.1|WP_038425973.1|1569472_1570870_-|histidinol-dehydrogenase
MSENIMRIIDLRGQHLSRAELLAAMPRAAMGTSEATDLVRPILDDVKERGAAALRDFEEKFDHVRPKNLRVPVESIKDALTTLDPEVRAAIEESVRRARAVAANQVPKDFYTDLAEGARVAERWIPIQRVGLYVPGGKAVYPSSVIMNAVPAQAAGVESLAIATPPARDNEEGLPNKTILATCAILGVDEVYAVGGAQAIAMFAYGAKGSEPQDGDILCDPVDKITGPGNIFVATAKSLVSAFVGIDAVAGPTEIGIIADATANPSLLAADLIGQAEHDELAGSVLFTDSTEIADKVQENLKYRVPRTEHAERVHTSLSGTQSAIVLTDGLDQSIDAANAYAAEHLEIQTKDADAVVKRIKNAGAIFRGPYSPVPLGDYMSGSNHVLPTGGTARFAAGLGVHTFMKPVEVIEYDEEGLKALAARINAFAVSEDLPAHGECVLSRFVKDPYDKATLREQEKGAGLR
>NC_014169.1|WP_013141013.1|1590988_1591291_-|YggT-family-protein
MLSLVLSLIGRILAWLINAYITVLFVRMILDWVSVLARNWYPRGVVAQLINIVYSITEPPLRWLRRYIRPLPLGSIYLDVSFIVLYFALVVLESVVLIVF
>NC_014169.1|WP_013141014.1|1591412_1591892_-|cell-division-protein-SepF
MAGFMKNAMSYLGMSDVVDDEDDYIEEDEEQKPAPKSAFDSDHTVTPLASTTAPAASSTTKPFPGGRVNRITTIHPKSYEDAQLVGRALRDGVPVVLNLTGVAEAVAYRIVDFSAGVVFGVRGSLERVTPRVFLLSPAQVNIKVEEPTKPTSAHDLFAD
>NC_014169.1|WP_032684064.1|1591904_1593107_-|cell-division-protein-FtsZ
MSEIAQNEFNDKTNIKVVGVGGAGGNAVNRMIAEGLQNVEFVAVNTDAKDLLRSDADVKISLSDQSSRGLGAGADPEKGAKAAQDHQSDIEESLKGADMVFVTCGEGGGTGTGASPIVARAAHQQGALTIAVVTRPFSFEGPQRSASAEYGIDNLRKEVDALIVIPNDRLLELSDRSIGIIEAFKTADTALLAGVQGITDLISMNSYIHVDFSDVNSILRGAGTALFGIGSARGEDRATQAAEIAISSPLLEESIEGAHGALINIAGPTDLKLQEASAATELVRKAIHPEAQIIWGLALDDAYGDEVRVTVIAAGFDPVTPQDPSAAAPAIAVPAAQPAATQTQQPAAAPAAQPVATPRPEFTPTTADPASLPFDDPTTSHPNIAVNDPAGDLDIPDFLR
>NC_014169.1|WP_013141016.1|1593218_1594463_-|tRNA-dihydrouridine-synthase-DusB
MAESETETTITATHETNNLDPRTDAPARPETPVHIAPVQLGNITVPTPVVLSPMAGVTNWPFRVICEEYGPDGLYVAEMITARALVARNPKALRLCHFAKSEKIRSLQLYGVNPSITEQAAKIVVDGNMADHVDLNFGCPVPKVTRRGGGSALPWKTDIFTELIQRVVAVCEPAGIPVTSKIRVGIDHNHETFLEAGHIAQEEGCKAVTLHARTTAEYYGGHSDWSRIGELKEHLNIPVFGNGDIWGAEDALEMVRETGCDGVAIGRGCQGRPWLFANIKNAFEGNPERLNPNLGEVCRVIHRHAELLTEFYEGDEMMAVHDLRKHIAWYLKGFPVGGSTRKAFMECESLADVDREIGKLDPTIEYPPRVVDKPRGRVRFAKKVHLPYGWLESRTTTHEEREALFGDDPMDASY
>NC_014169.1|WP_013141017.1|1594613_1596086_-|glycine--tRNA-ligase
MAQSKLDEVVSLAKRRGFVFPAGEIYGGTRSAWDYGPLGVALKDNIKREWWRSMVVTRPDVVGVDTSIILPPEVWVASGHVSVFNDPLVECLNCHKRNRADKLEESYAEKHGDKMPENGMKDIVCPNCGTRGQWTEPRDFNMMLRTHLGPVEDENSLHYLRPETAQGIFVDFKNVMTSSRSKPPFGIANMGKSFRNEITPGNFIFRTREFEQMEMEFFVTPGTDEEWHQYWIDARTRWYIDLGVKPENLRHYEHPKEKLSHYSKRTVDIEYKFGFQGSDWGELEGIANRTDFDLSAHSKHSGEDLSYFNQATGEKYVPYVIEPAAGLTRSLMCFLVDAYDVDEAPNTKGGVDKRTVLRLDPRLAPVKAAVLPLSKKPELQTVAQNLADDLRFNEWMIDYDESGAIGRRYRRQDEIGTPLCITVDFDTLEDHAVTIRERDTMAQERIALDKVADYVAARIGEKRTRVPLKPVEMGGEPWPESGVQEAGGLY
>NC_014169.1|WP_013141019.1|1596520_1597465_+|hydroxyethylthiazole-kinase
MSNSASSFTGMSSGCTAGTPVPADSPIRDNIADAVRRVRETTPLAQSFTNFVTINLVANAQLAAGGTAAMSFLPDDVIETAKIAGANYINVGTLLPFYKDALPEIAQRLNYLDKPWVLDPVAAGIGHTRTAILQAFKAAPPTMIRANASEVIALANMWGLNTETVGDASEHRPAGVESVDDVESATGAAVALAQYLTEQHAKHSSHDASTRCAVAVSGIADLVTDGETVYRLPGGSAMMTKITGAGCSLGGVAATYLAVSDPLTAALSASLLYNRTAEIADTTSHGPGSFQVAFLDALWNVTAEQVAESEILVQ
>NC_014169.1|WP_013141020.1|1597547_1600301_+|phosphomethylpyrimidine-synthase-ThiC
MSNEYPYASMRDNFDLSAYFVVGPEDCKGRPLTDVVDQALHGGATFIQLRAKEADASELTDMARDIAQIIEDNEKSDSVAFVIDDRADVVWQARRKGIKVDGVHIGQTDMEPREARALLGDEAIVGLSAETESLVQLINELPDGCIDYIGAGPLHVSTTKPEASVGGNDGSGKTLDAAQINTICAASEFPVVVGGGVTAADMAMLAGTKAAGWFAVSAIAGAENPEEAARTMVEGWKAVRGDKKHGYAPRVVAHTPAADTQAAQEGAAKPGSEATEKKFTNAKDAKDAQKLAKQQRVDIAARGSKQRDKAHIRKTKSVPFTYQYGSYDLEVPYTEIKLSDTPGVGPNPPFHDYNTEGPKCDPKEGLKPLRLDWIRDRGDIEDYEGRRRNLEDDGKRAIKRGRATKEWRGRKHEPMRAKDHPITQMWYARHGIITPEMQYVATRENCDVELVRSELAAGRAVMPCNINHPEAEPMIIGSAFLTKLNANMGNSAVTSSIDEEVEKLTWATKWGADTVMDLSTGNDIHTTREWILRNSPVPIGTVPMYQALEKVEDDASKLSWELFRDTVIEQCEQGVDYMTIHAGVLLRYVPLTANRVTGIVSRGGSIMADWCLRHHQESFLYTHFDELCDIFAKYDVAFSLGDGLRPGSLADANDAAQLSELMTLGELTERAWAKDVQVMIEGPGHVPFDTVRMNIELEKAVCHNAPFYTLGPLTTDTAPGYDHITSAIGATEIGRYGTAMLCYVTPKEHLGLPNKDDVKQGVIAYKIACHAADIAKHHPHAMDRDNAISKARFEFRWLDQFNLSYDPDTAIAFHDDTLPAEPAKMAHFCSMCGPKFCSMAISQNIRKAFGGEAAQQQIVKEAAAGIDSEALAKAKANVDNGVVSANVLSPEEILAGMDAMSEKYTAQGGKLYSTAQE
>NC_014169.1|WP_013141021.1|1600337_1601546_-|26S-protease-regulatory-subunit
MADNDVLRRDGVLVRITGFDDERTAYFAVMPNGHTTQLTFPRQEVFDVGDVLLVGTDFYRKVPHDVWPLKPRVGIVRRALNEGVVLETSDGLELLEGDYPNSIMPGNTVQFTDLFGIERVLWPTAIRPGESDHDDDIKQYRITPGSDPSLTFDSFGGYEQVITRAKELIETQLGNSAQMRAIGAKPIKGVIFTGAPGTGKTHLARIIANVADAQFYLVSGPTIVSKYVGDSEETLRMIFAAAQADKRAIIFFDEIDSIASSRENDTNGVGKRLVAQLLTLMDGFESKGNVVVVAATNRIEDVDPALLRPGRFDWQIPFPMPSEHDRLGILQVQARSLSIEGELPLADIAQRTEGWSGAEVCAIWTEAALVAAKDRRGAIRAADLVTAFERVERRPELRHHRA
>NC_014169.1|WP_013141022.1|1601672_1602482_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MAQIATSTLPAVLAISGSDSSGGAGMQADLKTMLACGVFGMSAITALTAQNTTGVRSIQDTKPDILADQINMVFEDIPPVAVKIGMVSATDIIDVIAERLTFHHATNIVLDPVMVATSGAKLISDDAIAALTGKLFPMATVVTPNIPEAEVLTDTLIRDQEDMEAAAHRIVERYGCAALVKGGHGTEDANDVLAETDGTVTWFDGARINNPNTHGTGCTLSSAIASYLALGDTLPKAIKHAKKYLTGALKAQLNLGHGSGPMDHFWKYR
>NC_014169.1|WP_003830347.1|1602545_1602923_+|thiamine-binding-protein
MVLDRNAVTQEVPIDPETGKPYLNTVAAIQVSANGVGSEVSPYVAQAVEVIRESALPQETNALFTNVEGNLDDVLKVAGEAAKKLAEQGYRTSLVLHMDIRPGFTGQLTEKPKLVDEILADKQAK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_014169_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014169_3

2052432-2052517

Orphan

Consensus_repeat	Method
GGCCCTGAGCGTGCGGGCGCGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014169_3

>merge|NC_014169|3|2052432-2052517|CRISPRCasFinder
GGCCCTGAGCGTGCGGGCGCGGAATCGCATTTGAAGCGGCATTGCCGCCATTGGCACCGGCGCCGCCCTGAGCGTGCGGGCGCGGA

>NC_014169|3|3|2052432-2052517|CRISPRCasFinder
GGCCCTGAGCGTGCGGGCGCGGA	ATCGCATTTGAAGCGGCATTGCCGCCATTGGCACCGGCGC
CGCCCTGAGCGTGCGGGCGCGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014169.1\|WP_007056739.1\|2042172_2042325_-\|hypothetical-protein	unknown	unknown	unknown
NC_014169.1\|WP_013141295.1\|2040397_2042014_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235787
NC_014169.1\|WP_013141298.1\|2045558_2047097_+\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|236994
NC_014169.1\|WP_187287443.1\|2042647_2043538_+\|ribonuclease-HI	unknown	unknown	gnl\|CDD\|260010
NC_014169.1\|WP_008782960.1\|2044798_2045431_-\|hypothetical-protein	unknown	unknown	unknown
NC_014169.1\|WP_007052305.1\|2053322_2054390_-\|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl\|CDD\|237061
NC_014169.1\|WP_007053049.1\|2063776_2064319_-\|50S-ribosomal-protein-L17	unknown	unknown	gnl\|CDD\|235522
NC_014169.1\|WP_007053050.1\|2062783_2063695_+\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|211337
NC_014169.1\|WP_013141297.1\|2043668_2044367_+\|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl\|CDD\|234816
NC_014169.1\|WP_014485335.1\|2054597_2055326_+\|hypothetical-protein	unknown	unknown	unknown
NC_014169.1\|WP_013141305.1\|2060327_2062508_-\|circularly-permuted-type-2-ATP-grasp-protein	unknown	unknown	gnl\|CDD\|379601
NC_014169.1\|WP_007053048.1\|2064418_2065414_-\|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl\|CDD\|235359
NC_014169.1\|WP_008783615.1\|2056942_2058511_-\|alpha-N-arabinofuranosidase	unknown	unknown	gnl\|CDD\|226064
NC_014169.1\|WP_013141300.1\|2048333_2049497_-\|tRNA-pseudouridine-synthase-B	unknown	unknown	gnl\|CDD\|235113
NC_014169.1\|WP_013141299.1\|2047111_2048236_-\|bifunctional-riboflavin-kinase/FMN-adenylyltransferase	unknown	unknown	gnl\|CDD\|235536
NC_014169.1\|WP_004268639.1\|2044517_2044607_-\|AURKAIP1/COX24-domain-containing-protein	unknown	unknown	unknown
NC_014169.1\|WP_007055304.1\|2059320_2060121_-\|transglutaminase-family-protein	unknown	unknown	gnl\|CDD\|224224
NC_014169.1\|WP_013141304.1\|2062475_2062787_+\|hypothetical-protein	unknown	unknown	unknown
NC_014169.1\|WP_007053811.1\|2055366_2056410_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_014169.1\|WP_013141301.1\|2049498_2049975_-\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|234787

Protein	Function_ID	Function_description	E-value
NC_014169.1\|WP_013141295.1\|2040397_2042014_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|235787	PRK06370, PRK06370, FAD-containing oxidoreductase.	1.62484e-125
NC_014169.1\|WP_013141298.1\|2045558_2047097_+\|DNA-repair-protein-RadA	gnl\|CDD\|236994	PRK11823, PRK11823, DNA repair protein RadA; Provisional.	0
NC_014169.1\|WP_187287443.1\|2042647_2043538_+\|ribonuclease-HI	gnl\|CDD\|260010	cd09278, RNase_HI_prokaryote_like, RNase HI family found mainly in prokaryotes. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD), residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Prokaryotic RNase H varies greatly in domain structures and substrate specificities. Prokaryotes and some single-cell eukaryotes do not require RNase H for viability.	1.98354e-61
NC_014169.1\|WP_007052305.1\|2053322_2054390_-\|transcription-termination/antitermination-protein-NusA	gnl\|CDD\|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	8.02178e-151
NC_014169.1\|WP_007053049.1\|2063776_2064319_-\|50S-ribosomal-protein-L17	gnl\|CDD\|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	1.51666e-56
NC_014169.1\|WP_007053050.1\|2062783_2063695_+\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|211337	cd02570, PseudoU_synth_EcTruA, Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1). Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E. coli TruA makes psi38/39 and/or 40 in tRNA. psi38 and psi39 in tRNAs are highly phylogenetically conserved. P. aeruginosa truA is required for induction of type III secretory genes and may act through modifying tRNAs critical for the expression of type III genes or their regulators.	2.46851e-94
NC_014169.1\|WP_013141297.1\|2043668_2044367_+\|ribose-5-phosphate-isomerase-RpiA	gnl\|CDD\|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	4.21378e-120
NC_014169.1\|WP_013141305.1\|2060327_2062508_-\|circularly-permuted-type-2-ATP-grasp-protein	gnl\|CDD\|379601	pfam14403, CP_ATPgrasp_2, Circularly permuted ATP-grasp type 2. Circularly permuted ATP-grasp prototyped by Roseiflexus RoseRS_2616 that is associated in gene neighborhoods with a GCS2-like COOH-NH2 ligase, alpha/beta hydrolase fold peptidase, GAT-II -like amidohydrolase, and M20 peptidase. Members of this family are predicted to be involved in the biosynthesis of small peptides.	0
NC_014169.1\|WP_008783615.1\|2056942_2058511_-\|alpha-N-arabinofuranosidase	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	0
NC_014169.1\|WP_013141300.1\|2048333_2049497_-\|tRNA-pseudouridine-synthase-B	gnl\|CDD\|235113	PRK03287, truB, tRNA pseudouridine synthase B; Provisional.	4.18623e-101
NC_014169.1\|WP_013141299.1\|2047111_2048236_-\|bifunctional-riboflavin-kinase/FMN-adenylyltransferase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	2.96421e-82
NC_014169.1\|WP_007053048.1\|2064418_2065414_-\|DNA-directed-RNA-polymerase-subunit-alpha	gnl\|CDD\|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	0
NC_014169.1\|WP_007055304.1\|2059320_2060121_-\|transglutaminase-family-protein	gnl\|CDD\|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	3.46877e-29
NC_014169.1\|WP_007053811.1\|2055366_2056410_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.46775e-80
NC_014169.1\|WP_013141301.1\|2049498_2049975_-\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	1.51112e-44

>NC_014169.1|WP_013141301.1|2049498_2049975_-|30S-ribosome-binding-factor-RbfA
MAGTNPRAARIAALIQRVVASSIERELHDKRLASITVTEVRVTNDLQIAKVYWTQLGHEGHEEGERKRAQQALDQAKGHLRSLVGHKAGLRLTPQLQFVFDEVPGEAHEIEDILAVAKKRDEELARARATAQYAGDADPYKHDDEAEAEGDEFESDEE
>NC_014169.1|WP_013141300.1|2048333_2049497_-|tRNA-pseudouridine-synthase-B
MLHTTPSGLLIIDKPQGVTSFDAVAAVRGALHIKKVGHAGTLDPMATGTLVIAFGHATRLLNAIMAHDKTYEATIRLGLRTTTDDAEGEVLVDDEARSRWQTLSAQLTEGGQSGEPTALPTASWQDLLTRTIATNFTGDIEQVPNTFSAIKINGQRAYDLAREGKEVELKPRPVTISEFTVLNIRSGFVAGEQAAEPLREDANTGTIPALDIDVRVSCSSGTYIRALARDLGNELGVGGYLTRLRRTRVGRFALPDDTSGLIASEAMLDTRTHTVTAHTDQKTFTNREGQTVTRNKCVLNTPEGLAGDERRNWLLDHALTMEQAARGAMPALDITPEEASELRFGRRIERAISESTAAIVPQTHDVAAIIERANAHQAKPVTVFPLA
>NC_014169.1|WP_013141299.1|2047111_2048236_-|bifunctional-riboflavin-kinase/FMN-adenylyltransferase
MDITHLTPDAEGSIEWPSFSNDKKAVVTLGAFDGMHLGHQAVIKRVVELAHQHGAFSVVILFDPRPAFVHGWAASHHGEEPAVQNVDAEALTSVDDRLHRMEQFGVDHVLVVHYTLAFAAMSYIFFLGRLTGKLGMRTLVLGQDAAMGKGREGDVKHIANLAVATGVFELDVVDDRGPGEVRIPRDFKPEAPSGWGEPVDPLANATKAERRAWSKKNQAKAMRAWSSTNVRYLLAHGRIQDANAILGAPHAIEGEVVHGEERGRTIGFPTANLGSDIAGYIPVDGVYAGWLVDGENRWPAAISIGTKPTFSEKTGLNERVVEAYCITDEWIDLYGHKVRVEFIGFLRPQVKFDGPDQLVDELKRNVEETKRLTA
>NC_014169.1|WP_013141298.1|2045558_2047097_+|DNA-repair-protein-RadA
MAKSSVQYVCSECGWNGPKWYGRCPECGQWGTVEEFHEARPAAGSRTAAPGRTSRTQSVTVADNARSAARPITEVGTESVERLGTGFSEFDRVLGGGVVPGSVTLIAGEPGIGKSTLLLQTAGNIARVVAGDSTFRGAGQRSAQQSGRAQGGTSNTVSVQGNAPSVHANTVLYISGEESQAQVRLRASRINAVEPNLLLASTTDLSTVLGLIEQNKPALAIVDSAQTIVSQEVDGISGGSTQVREVASALIDTAKTLDIPVFLVGHVTKDGSIAGPRTLEHLVDVVCQFEGDSETALRMLRAVKNRFGPTDEVGCFDMSGEGIEEVTDPAGLFLSGDGPDAANAAPMEGTCVTFTLDGHRSLPIEVQALVTTSVLPTPRRAVNGVDPSRIAMLVAVLYRHSKLNLLSNDLYISTIAGGQAKEPGSDLAIVAALASAATSKPIARATCAIGEISLTGQVRPVPRMEYRLREAARLGFTTAVIPPLRKPVHVEGLRLVESNTLSDALDALGVRK
>NC_014169.1|WP_008782960.1|2044798_2045431_-|hypothetical-protein
MTNSENSSTTQSHGKLIAVVVAAAVVIILAVLSAFVWPGWAIQKNDGTSTTTQNSQQKTESSEPIKPTIDATALPDDASELLKAMPDSVLNYARTKADASTTWNSASPLEEYTLTYSTGDAAKDVTLVAAQWSSADNAKTQYDALVAAQTGDESASGNVKVSGNVTGAYVVKADASNSKNAAAIWQNDTVVFQATGTKEAVDRFYQKFPM
>NC_014169.1|WP_004268639.1|2044517_2044607_-|AURKAIP1/COX24-domain-containing-protein
MGSVIKKRRKRMSKKKHRKLLRKTRHQRK
>NC_014169.1|WP_013141297.1|2043668_2044367_+|ribose-5-phosphate-isomerase-RpiA
MDKAQQDALKKAAGIEAAKLVENGMIAGLGTGSTVKFLVDELGRRHQEEGLEFTGVTTSRRTQVQAESYGIKIVDIDDVDHIDVTIDGADEVDKNFNGIKGGGAALLWEKIVATNSNQIVWIVDESKVVDTIGKFPLPVEVIPFGAGHVIKKFEDRGYKPVLRLDADGKEVRTDENNFVVDLHLERIDHPQELAEDLINTVGVVEHGLFLNMVDKVIVGDPNGPRVLTNANK
>NC_014169.1|WP_187287443.1|2042647_2043538_+|ribonuclease-HI
MTITVSTDGSALGNPNGPMGWAWADHEQNAGGKPGHKHDDHGYDAGGATNGTNQIGELCAVLEALRAHPGPEPLLIESDSQYAINCSTKWVKGWKKNGWKNSQKKPVKNKELIQAIDREISQRPGPVDFRWVKGHAGNEGNELVDELARTYAGDCRSGARDGYLPIEGWQSLLGSEYAHGTDVPPDVQLVLDGKADAASLRKPAAATDSTDATRPETKSSSPLATQSAQPVQSAHPVHPAKPSGLTVSGTLTFSPAPKTSPYFNGQSMPIKGSIEIEGYVDGDGNLTITNAPFVRH
>NC_014169.1|WP_007056739.1|2042172_2042325_-|hypothetical-protein
MLIAGNSKTVALGPGGMALAPGLPLGLGWFIRRRLGLDASDILDRKLGLK
>NC_014169.1|WP_013141295.1|2040397_2042014_+|FAD-dependent-oxidoreductase
MSISTPNAISTPNTSPTITTDALIIGFGKGGKTLAAKLSAAGRKVVVAEASADMYGGTCINIGCLPSKSLILSAEQARRDGANSTPETREAAFEAAIKEKRRVTSMLRDKNYHKLADQDNITVITGRAHFTGPHSVEIATAEGPVAVTASKIFINTGATPRIPDIPGIRTTPGVYTSTGLMDLDDMPQRLVIIGSGFIGLEFASMFADFGTAVTVLQHNAEFLPREDADVAAAIRAQLEAQGVKFLFNADTKAIAPAADGGVRLSVAVKGMTRGASQACDSTPAGTGNAHTDITGATDTATTTSPTGNPTDHATMSHVQTKPSDDGEPRFAEPAEARFCLTTDAVLVATGRTPNVEGLHLEAAGVELTERGAVKVDELLRTTAADIWALGDVNGGPQHTYISLDDYRVVWSQLSGSDRPYTVKDRKHVPSSTFLATPYSRVGLNEREAKAAGLDYVVKRLPVAAVPKAQVMRRPDGLMKAIVERNTGRILGAMLLSVESHEVINIVKLAMDLDAPASTLRDMVFTHPTIAEALNDLFA
>NC_014169.1|WP_007052305.1|2053322_2054390_-|transcription-termination/antitermination-protein-NusA
MELDLTGIHKLAAEQGIDPETLDDALAEALRLAYLKTPHAAKHARVELDERSGNFTVWAADEIPVEPTEDNPYPAPKLGEEYDDTPRDFGRLAAATARQVITQLFRRAEDEKVFGAFSGQKGKLITGIIQQDASDPSNVHVAMGDVEAILPRREQVPGERYRHGERIRVYVVNVARGIKGPEIVVSRSHPELVRKLFEREVPELVSGAVSIMAIAREAGARTKIAVKANTDGVNPKGALIGPGGARVRAVMENLGPEKIDIVDYSDDPAKFVAAALSPAVATGVQVISEKNKTAIAFIHDDQLSLAIGKEGQNARLAAKLTGWKIGIESAEAHAKKVAAEKAAQAAAEAAAPEAE
>NC_014169.1|WP_014485335.1|2054597_2055326_+|hypothetical-protein
MSPCEKAMTLAGYATHPAEGTPLLEQYATGLAAPLAWIDVAGYCSGRFAEGTLRDAQTKQWLAFLADKFGQSAPEVTPARLDGVTSANVDRSVLDAMAVAEDRAGFAIEVLAARGQTAGATLALSDMHKTAGQQLVSLANGNFDDSGAQSSSSGQSDPRQKVYAIDQLLANPTTIADKASGQTVPTAAAIEMDCARAQIKAVTESKSSTESDMLLILAALAAKHAYTAFQLGYPATDAALFE
>NC_014169.1|WP_007053811.1|2055366_2056410_-|LacI-family-DNA-binding-transcriptional-regulator
MGNRVTIKDVAREANVSIKTVSNVLNDTGSMRPDTRRRVEEVMRKLGYTVNISARAMRSGGTKLIGLNIFDFSQPFVPFFTDKVIEYAKERHYGVVINTYGSDGEGLVASVDESYRLGAEGWILFVMSPLADEGAVLEQPYPIVTTGDHLAYGKSDWITMPNIESISTVVGRFLDEGAQTVALMGVLPELVDEAVLRRQTEGTQALRAQGYVKAFEERGLSVNWRYVIPAESMNQREGMRVTKAMLDKLPCPDVVVCLNDAIALGAIHELQRCGLHVPDDVQVVGFDNVPEAEYSVPALTTIDPHIDDYAKHAVDMLIDRIEGYSGPARTYTTDFTLVERASTRLAH
>NC_014169.1|WP_008783615.1|2056942_2058511_-|alpha-N-arabinofuranosidase
MSEHSHDNKPGELEESRLVVDNDFEVAPVNDRLFGSFVEHLGRCVYDGIYEPGHPEADEDGFRKDVIELVKELGATTIRYPGGNFVSGYRWEDGVGPRDERPRRLDLAWHSTETNQFGLHEMAKWLEKTGGNELMEAVNLGTRGLEEALDLLEYANIPGGTKLSEERRANGADQPFGIKMWCLGNEMDGPWQTGHKSAEDYGTLAASVAAGMRAIDPNVELVVCGSSSHVMDTFGKWEETVLEKTFDNVNFVSCHAYYHPELQPDGTRDMKSFLASGVDMDGFINDVAAAIDATKARLKSKHDVFISFDEWNVWYLNEEPSKNPEGIGNWPVAPRLLEDVYSAADAVVFGDLMITLLKNADRVHAASLAQLVNVIAPIMTEPGGPAWRQTTFYPFSLTAKLAKGGTVLEPKLASGTYETDKYGEVPTINSVAVRGEDGTISVFVVNRSMEAANDFAIKLPEGFALSAVEAQTLHEDDLLAKNTLEDQNRVVLHPNTTITSDADTGTVRVTLPPVSWTAVHVK
>NC_014169.1|WP_007055304.1|2059320_2060121_-|transglutaminase-family-protein
MKKLVFDYEMRLSFSAPVTDHRFQLRCIPSTGPRQQVIDVEVKIQPETELETTIDSFDSVVMTGFIPEPHDIFSYSVTGIAFVDNAHIHKEAYKPLYRFNSALTIPGPNVEAMIAVCRERLAALPSDATPVQQAAEVMDEVYKAFVYTPGSTTIRTTAEQALAQRKGVCQDYAHVMLSVCRHVGLTARYIAGLLGGEGATHAWVEVYQDGRWVGLDPTHNRLVDDSYITIAHGRDYRDCMLDIGIFSGYNVQQSQWVNASVHEQVA
>NC_014169.1|WP_013141305.1|2060327_2062508_-|circularly-permuted-type-2-ATP-grasp-protein
MIESAARRLAHELVNRREAINRELSRNGVRFGIYKNGEYHDRLFPYDPVPRIIESDEYDELEKGLKQRVNALNAYLKDIYSDKAIIHDGVVPEEYVYTSAGYFPQVNGVTPPGGIFAHIAGEDLVQGEDGRWWVLEDNLRIPSGASYPLFVRDIERRISPRLFRDVRIRDNREYPRLLRKAMDFVSTEGIAVVLTPGRYNSAFFEHAYLAEKTGAALAFPEDLEVVDNKVYFLDYAGKRHRVGVVYRRLSDEFLDPFAFNPDSVIGVPGILSAYRAGNVAIVNAPGNGAADDKAIYYFVPQMIKYYLGEEPILNNAPTYMPMFEADRKEVLNRMGELVIKDVAEAGGYGVVFGSSLDAAAREELANRIKEEPRRFIAQEVIQFRDIDVVDPKTGEMSPRKCDLRAFVVTGKNTHVWYSGLTRYSSVPGQMIVNSSQGGGFKDTWVLAPESGVEHEYGAETQVVNLLNQSRRHSLSLVTASKADNLYWLGRYTERAFTTLNQFFPFYDRVMDTDVDAFRPFAHALDLPEDFEDFDGFVNSFLYDGSNPDSVRSAVTSAFNNAVILRPELSSRLLQYVELAMTNITDAAKYAADAEDIYKQRDITDDMLAFWGGIENSPVDPTLKAFIFIGKYLERIDLYTRFGLTMEELEAPLKKLAAYSMTLDGMPLPSCFADGLSWLVGQLPSRGYQEVADLLKKHLDDYSGRVSALAIKDMGSLSSMNMDAKRP
>NC_014169.1|WP_013141304.1|2062475_2062787_+|hypothetical-protein
MGQSACCGFDHRACSLLWRLLWLQAVRRFERTLTPQAVTGFDGFNLRRARFNKRARMLQAGHFAGRVHLDDRTRLADHTHLADRTHLDDRTRLADRTRYNEWL
>NC_014169.1|WP_007053050.1|2062783_2063695_+|tRNA-pseudouridine(38-40)-synthase-TruA
MTRLRIDLAYDGGGFYGWAKQPNLRTVQGTIEDALHKVLRVPTDDAAEPLRLTVAGRTDTGVHASHQVAHLDVSDEVLNRCVGHMTIPVTEALTRRLKAVLPSDIVIHGIAVAPVGFDARFSALERTYVYRVADRSSEVDPRLRGCVLTVDEALDLELMNRAASLTIGLHDFGSFATPNPGGTTIREVKTAYWRRVPITPLVPDEMASHEAYRTPSLESGLVVFTIVADAFARNMVRSLVGSCIKVGSGRKSLEWFAGKMAEPVREGSSGPIAPQGLTLEHIAYPADDQLAARAEAIRAVRTL
>NC_014169.1|WP_007053049.1|2063776_2064319_-|50S-ribosomal-protein-L17
MPTPKKGPRLASSPAHERLMLANMATSLFQNGRITTTLPKAKRLRPLAERLITFAKRGDLHSRRRVMRVIRNKSVVHILFTQIAEQMEQREGGYTRIVKIAPRVGDAAPAAVIELVTEPVAKKAVVKEAEAAAKVAEEEAPAVEAEATEAAEAVEAPVEETAAAEAEAPAEEAADAEKAE
>NC_014169.1|WP_007053048.1|2064418_2065414_-|DNA-directed-RNA-polymerase-subunit-alpha
MLIAQRPTLTEESLNPQRSRFTIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSVRISGALHEFTTLPGVQEDVTEILLNIKGIVLTSEYDEPVVMYLRKSGKGEAVAGDITPPAGVTIANPEQHIATLADDGELEIEFTVERGRGYVPAQMNKQDNDEIGRIPVDSIYSPVLKVSYKVEATRVEQRTDFDKLILDVETKPAISPRDAVASAGSTLVELFGLCRELNAQAEGVEVGPAPVAEETNPEMAVPIEDLNLTQRSYNCLKREGIHTIGELVSHTEQDLLDIRNFGMKSIDEVKEKLQTLGLSLKSSPMAFDTNNLEGGTFFSPEDE

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_014169_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014169_4

2189090-2189164

Orphan

Consensus_repeat	Method
TCTGTCCCGGTTGCCCCAAAAGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014169_4

>merge|NC_014169|4|2189090-2189164|CRISPRCasFinder
TCTGTCCCGGTTGCCCCAAAAGAGGCAAAATGACGAACCGGGACAGCGAAATCTGTCCCGGTTGTCCCAAAAGAG

>NC_014169|4|4|2189090-2189164|CRISPRCasFinder
TCTGTCCCGGTTGCCCCAAAAGAG	GCAAAATGACGAACCGGGACAGCGAAA
TCTGTCCCGGTTGTCCCAAAAGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014169.1\|WP_013141368.1\|2190860_2191973_-\|homoserine-kinase	unknown	unknown	gnl\|CDD\|234920
NC_014169.1\|WP_013141361.1\|2180373_2181636_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340952
NC_014169.1\|WP_013141360.1\|2179604_2180372_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|226145
NC_014169.1\|WP_022527887.1\|2188097_2188274_+\|DUF1778-domain-containing-protein	unknown	unknown	unknown
NC_014169.1\|WP_013141367.1\|2189269_2190724_-\|Maf-family-protein	unknown	unknown	gnl\|CDD\|178901
NC_014169.1\|WP_013141365.1\|2185262_2186711_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669
NC_014169.1\|WP_038426192.1\|2195150_2197013_-\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|223097
NC_014169.1\|WP_013141359.1\|2178599_2179493_-\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|223406
NC_014169.1\|WP_013141374.1\|2202551_2203679_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|239204
NC_014169.1\|WP_029680412.1\|2197101_2198034_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NC_014169.1\|WP_013141370.1\|2193555_2195148_-\|diaminopimelate-decarboxylase	unknown	unknown	gnl\|CDD\|143501
NC_014169.1\|WP_013141373.1\|2198127_2199381_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|224090
NC_014169.1\|WP_013141364.1\|2182757_2184041_-\|fuconate-dehydratase	unknown	unknown	gnl\|CDD\|239440
NC_014169.1\|WP_013141362.1\|2181825_2182617_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181508
NC_014169.1\|WP_007053081.1\|2201001_2202348_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|181958
NC_014169.1\|WP_013141369.1\|2192079_2193396_-\|homoserine-dehydrogenase	unknown	unknown	gnl\|CDD\|235783
NC_014169.1\|WP_038426032.1\|2184252_2185281_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380519
NC_014169.1\|WP_007056295.1\|2199426_2200752_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NC_014169.1\|WP_013141357.1\|2177578_2178523_+\|AEC-family-transporter	unknown	unknown	gnl\|CDD\|223751
NC_014169.1\|WP_013141366.1\|2186707_2187658_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222

Protein	Function_ID	Function_description	E-value
NC_014169.1\|WP_013141368.1\|2190860_2191973_-\|homoserine-kinase	gnl\|CDD\|234920	PRK01212, PRK01212, homoserine kinase; Provisional.	3.74719e-88
NC_014169.1\|WP_013141361.1\|2180373_2181636_-\|MFS-transporter	gnl\|CDD\|340952	cd17394, MFS_FucP_like, Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.23367e-96
NC_014169.1\|WP_013141360.1\|2179604_2180372_-\|amidohydrolase-family-protein	gnl\|CDD\|226145	COG3618, COG3618, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	9.17671e-40
NC_014169.1\|WP_013141367.1\|2189269_2190724_-\|Maf-family-protein	gnl\|CDD\|178901	PRK00148, PRK00148, Maf-like protein; Reviewed.	3.59913e-60
NC_014169.1\|WP_013141365.1\|2185262_2186711_-\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	7.1802e-06
NC_014169.1\|WP_038426192.1\|2195150_2197013_-\|arginine--tRNA-ligase	gnl\|CDD\|223097	COG0018, ArgS, Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis].	3.58864e-165
NC_014169.1\|WP_013141359.1\|2178599_2179493_-\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|223406	COG0329, DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane].	3.50104e-89
NC_014169.1\|WP_013141374.1\|2202551_2203679_-\|diguanylate-cyclase	gnl\|CDD\|239204	cd02810, DHOD_DHPD_FMN, Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires FMN as co-factor. DHOD divides into class 1 and class 2 based on their amino acid sequences and cellular location. Members of class 1 are cytosolic enzymes and multimers while class 2 enzymes are membrane associated and monomeric. The class 1 enzymes can be further divided into subtypes 1A and 1B which are homodimers and heterotetrameric proteins, respectively. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN and eight [4Fe-4S] clusters, arranged in two electron transfer chains that pass its homodimeric interface twice. Two of the Fe-S clusters show a hitherto unobserved coordination involving a glutamine residue.	1.22241e-94
NC_014169.1\|WP_029680412.1\|2197101_2198034_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.51664e-31
NC_014169.1\|WP_013141370.1\|2193555_2195148_-\|diaminopimelate-decarboxylase	gnl\|CDD\|143501	cd06828, PLPDE_III_DapDC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase. Diaminopimelate decarboxylase (DapDC, EC 4.1.1.20) participates in the last step of lysine biosynthesis. It converts meso-2,6-diaminoheptanedioate to L-lysine. It is a fold type III PLP-dependent enzyme that contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. DapDC exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity.	6.16092e-72
NC_014169.1\|WP_013141373.1\|2198127_2199381_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|224090	COG1168, MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism].	4.39791e-121
NC_014169.1\|WP_013141364.1\|2182757_2184041_-\|fuconate-dehydratase	gnl\|CDD\|239440	cd03324, rTSbeta_L-fuconate_dehydratase, Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to mediate the down-regulation of thymidylate synthase protein by a novel intercellular signaling mechanism. A member of this family, from Xanthomonas, has been characterized to be a L-fuconate dehydratase. rTS beta belongs to the enolase superfamily of enzymes, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	0
NC_014169.1\|WP_013141362.1\|2181825_2182617_-\|SDR-family-oxidoreductase	gnl\|CDD\|181508	PRK08628, PRK08628, SDR family oxidoreductase.	2.22565e-161
NC_014169.1\|WP_007053081.1\|2201001_2202348_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|181958	PRK09564, PRK09564, coenzyme A disulfide reductase; Reviewed.	4.86961e-92
NC_014169.1\|WP_013141369.1\|2192079_2193396_-\|homoserine-dehydrogenase	gnl\|CDD\|235783	PRK06349, PRK06349, homoserine dehydrogenase; Provisional.	0
NC_014169.1\|WP_038426032.1\|2184252_2185281_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380519	cd06296, PBP1_CatR-like, ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group includes the ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group belongs to the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	9.16589e-100
NC_014169.1\|WP_007056295.1\|2199426_2200752_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NC_014169.1\|WP_013141357.1\|2177578_2178523_+\|AEC-family-transporter	gnl\|CDD\|223751	COG0679, COG0679, Predicted permeases [General function prediction only].	1.81975e-36
NC_014169.1\|WP_013141366.1\|2186707_2187658_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	6.85345e-100

>NC_014169.1|WP_022527887.1|2188097_2188274_+|DUF1778-domain-containing-protein
MTSLQWALSNLLAAADRDIHEAHIIRLNSKAWNDFTAALNEPMGLRLNELLERDPIWT
>NC_014169.1|WP_013141366.1|2186707_2187658_-|ABC-transporter-ATP-binding-protein
MNTSASQLQQPQPASGPAAQPQQSQQPQQFQQPASHTQQWAPVIEAHDLVMDYTASMARAQAGHGVTGVMPAGTGAGYASANPAAAGPGAIQAGQPSQPSQPGFAMPTMHTLALNHVNFTLREGETVAVMGPSGSGKSTLLHALAGIIKPTAGTVVFRGTDLSHMSDADRTKLRRNVFGFVFQSGQLLPELPAVENIALPMMLDGVPYRTATDTAILWLERMGLRALAMHRPGEMSGGQMQRIAIARALAVKPAVVFADEPTGALDQATGREVMGILMAAARDNGSAVVVVTHDPNVASFCSRTVTMQDGQLGGVR
>NC_014169.1|WP_013141365.1|2185262_2186711_-|FtsX-like-permease-family-protein
MSTFALWRLFHRPGSRGSAGHTSVLAIIAFAAATTIFLTVLGGVHGFMWRASADHTIGCAINLDACKPGTAEIWKQRIANPHSLDQYATAYVVLAFFACLLLIVPFVALAGSAARLAASRRDARLASLRLAGATTGQVIRLTALDAAGQALVGALIGIAGYCVLIPLIMLLHFQNQTFTFEQLWVGPIALIITLVGVTVLALISSLVTLRRVAITPLGVTSRVATTLPSGWRVVVFAVIMVIAVLLFKNPMVLAQAGEVVMYGVIIGFMLLCFALVNLIGTWVVTARAKAKAKRPKDAATMIAMRRILDNPKRAWRNVSGIALAVFIAGITSICGFFGSAAVVGDANDPSTVFIRDIGTGGILTLVFAAVLAAVSSGVMQAGSVYDQAGEYRMLVLEGTDVKTLNRARFIEVLTPLNIVVIVAGGCSMLLMAPLFAASMTEPATLASFFGGLVLCYALVSVGAFASNRVAASLNLADYRADD
>NC_014169.1|WP_038426032.1|2184252_2185281_+|LacI-family-DNA-binding-transcriptional-regulator
MVNDTSTHKLKVGELAKIAGVSASTVSKVINGRTGISDETRRQVEQILKDHGYSRPLVNTKLSPTIELVVEYIEHNGTMELIKYASYWAQQAGLAITVTQTNHGDATEDCFRGIIDRNPQGVIMQQMGGLTTQAKSLLKSRSIPVVIIDPIDTVDSDVMSVSIDNWTAGYQAGKHLLSLGHRRIAVIRGPANLQTSIARYSGFTAALQQAGVDLPESYIEQGDYFPAETSYEAACRLLELTDRPTAIFCCNDLSAVSTYRAAREHKIALPKQLSVMGFDDIFPAGQLMPSLTSVHQPFSEIAQRAVQMIIDSRKGNQGDMHVILPTSVVTRESTVPPQSSAR
>NC_014169.1|WP_013141364.1|2182757_2184041_-|fuconate-dehydratase
MSTITKVKTYDFRFPTSTTLSGSDAMNPDPDYSSAYVEISTSADDGITGVGFVFTIGRGNDVVCKAIESMSQVLIGRNTEELLDNMRIAWDLFVHDSQLRWLGPEKGVEHMAIGAVLSALWDIKAKRAGKPLWLLLGEMEPEELVSTLDFRYMTDALRPEEAVAILKEGQKGKAERIKHLLEVGYPGYSTAPGWLGYSDEKMVALAKEETQVKGFKQIKLKVGQNINDDLRRLSKAREAIGPDVRLAVDANQVWDVPTAIDWINKFHDFDLAWVEEPTSPDDVIGHATIARAINPIKVATGEQMQSRILYKQYLQANAFGIMQIDATRVAGPQEIVLEYLLAKKFNKPVCPHAGGVGLCEAVCHFAMFDYVAVSGTMDGRMIEYVDNQHEHFVHPTEIKDGNYVAPTAPGNGTEMTLETAEKYLYRG
>NC_014169.1|WP_013141362.1|2181825_2182617_-|SDR-family-oxidoreductase
MDLHLEGKVIIITGGFKGIGKGITLQLAQEGAIPVVINRPDSALDEFKKDIEQYTTTYDVHLLDLNDTDKIAGVVEATYKKYGHIDGIVNNAGKNDNKDLETTTWREFEESLHGNLTHYYELVHAAVPYLKESRGSIVNISSKTALTGQGKTSAYAAAKGAILGLTREWAAALVHDSVRVNAIVVSECWTPLYADWIKTFGDEAAQQARLSVITDKIPLEHRMTTTEEIGNEAAFLLSDRSSHTTGQWVYVDGGYVHLDRALS
>NC_014169.1|WP_013141361.1|2180373_2181636_-|MFS-transporter
MTSKNTTGSKATIAIVLVTSLFFIWGLTMNLVNALNSPFANYIELSSAEASLLQVAYYGAYFVMAIPAGLIAKRFGYKGGVISGLLLFALGAFMVIPATSMASYGLFLFAMFVIALGAASLETNCNPYITKLGDEKGESFRINMAQSFNGVGNIVGPLILGQILGTTVASGESGFDAAKTQFLNDTRTIYIVIGVVLVVVLAVFALFKLPTPPGDEEEAAGGASSKNSSFFGLLKRPHFALGVLAEFIFIGLQVAGMAVFSAYALKHWGAGITAGTAAMMLSVLSLLFTIGRFVTTPLMAKFDPAKILGVYMTISAVLMFVVFLGLGKVSVIAFMVAYLFISIGYPTIFSLTLKGIKGSAAKTGSSALVMSIVGAALIPLLLGVIQDAAGIEIAILVMVPGFLFVAWYAFWGSKIGLKEA
>NC_014169.1|WP_013141360.1|2179604_2180372_-|amidohydrolase-family-protein
MTLNVIDSHFHIWDPDAQDLPWLAGLPSLQHKYTIEDLAAQYAKFGVNFLGGVYVEVDAADHELEDRLLYENASPLILKRMLQGRVSPWMRVPINADGIREPLHVDSEPRGRALEPEFIAGLRAMAAKGLPFELCNRGPELGDMAKAFAQVPEVTVIIDHLGNVPGLDEESCAALAALAELPNSYIKVSGDNPVDPDIVKYVRDTFGPKKVLYSSNWPVVELNSTFATHFQLMLDTFGEDEDFFENNARRAYNID
>NC_014169.1|WP_013141359.1|2178599_2179493_-|dihydrodipicolinate-synthase-family-protein
MTSSAEFSGIICPSITITKDDGDIDYERWGQHLDHLIEAGINGVLVFGSIGEFYAFPLDVKKQAVDFVAKHVAGRIKVFAGVGDTNLNNVIDFARAVEASGVDALVVVSPYYFGPTAGGAKAYFGAVAEATNLPVILYNFPPRTGSDLTPELVAELAAAHPNIVGIKDTVDTISHTRKVIRTVKAVNPRFAVFSGFDEYYLVNRVSGGDGVICGMTNVEPETFVTLHRAYEAGDYGTAIEAAERISHLMALYDQTDLFISAIKGAVKAKGLNISTLIREPAVQLTAQQYEAIKAILK
>NC_014169.1|WP_013141357.1|2177578_2178523_+|AEC-family-transporter
MSGLISAMQGFCVIGIVIAVGYVAARMRIGGPSAQMVLNRFSFFVSSPCLMFAILSKEPIFDIFHPSIIVAFFSAVLVGVVFLVLNRMFFHLNAPDATIGALNSLYLNSNNIGLPIATYILGNPALVAPILVMQQAIFTPVGLTVLDVTTKGKVSIKEIAKQPLHQPLLIGSLLGIVVSAISAKSGWFPVPKFIFDPIDMIGDSAVPMILMAFGMSLHGTKPLQQKGDRPAIFTVAVLKNIIMPIIAFLLAYFVMGFRGSELYACVVLAALPTGQNVYNYAARYNVGLTFARDGILMSTMTSPVFIAIIAALLS
>NC_014169.1|WP_013141367.1|2189269_2190724_-|Maf-family-protein
MSIPLILASKSKPRRDVLYSAGICPTIRVSHVDEPAALEAAAREEGVTVDDLSIKQRVMILAAAKAEAVHRAYRDVANTAAAATGDCVIAYPLKAKEIKDSEREAVVEDLRKAAAGQPIDYSKAEVATTRDFSGIDMPTVTEPIATAIAGQPGLTEATVGPLILGCDSMFLLDGECYGKPHSEAVARERLKRMSGATGELWTGHCLIDFATGRTVRGASHAKVHFGEFTDADIERYIVTGEPLEVAGSFTLEGFGGAFIDSIEGDPHGIIGLSLPLARHLAGELGITWTDLWNVGRGELEPESKASGNQHAGILPPVENVHQPGDGWVDCACGRKHWGTNGASGILLARRDPASGKVTHVVMQHRAAWSAEGGTWGIPGGATADGESSIEGALRESYEEANITPEDIEVVGSYREDHGPWAYTTVFAFEKPGHTVEPKANDDESMEICWVPIDDVPNRKLLTAMKTDWPRFAARLDELACAGHR
>NC_014169.1|WP_013141368.1|2190860_2191973_-|homoserine-kinase
MNPICNSVHVRVPATSANLGSGFDTVGLALDYHDELTFTLNDDPNDGIAHVIIHGEGADTLPRDETHLVVSTFRRACATFGLGRLGFTLEATNDIPQARGMGSSAEAIVAGIAAAAAFAQTGELNRPAIFDMAAQIEGHPDNVAPAVFGGLTVSWDFETAEGVGSVAVPGGEPLHGGFHAVNYPVDPSITAAVFVPDYELSTEKARQALPRELPYKDAVYNVSRVGLLPAAMNPVVLAQAAQQGKSGVAAAPAQDTDTCACADGTRESPFADELAAAQAQSNALLFTATQDKLHQPYRGTLMPPSTELIALFRSKGYAAAVSGAGPCVLVLHYGNAREAIDQIASEQLASGHWRVLHLPINTAGVEIERR
>NC_014169.1|WP_013141369.1|2192079_2193396_-|homoserine-dehydrogenase
MAHNSETPIRVGLLGAGTVGSQTARLIVEQKDELSARIGRPIELTGVACLDPKETEKFPWIDQSIVTTDTLSVATNSDIVIELIGGTTVARKFVLAAIESGASVVTANKALLAKYGPEIYSAAEAKGVDIYFEAAVGGAIPFLRPLRESLVGDKVTSMLGIVNGTTNYILDEMTTKGLQFDDVLKDAQAKGYAEADPTGDIEGYDAANKAAIMATLGFHTSVTIDDVSVEGITKITADDIAAATAEHKVIKLLAVVENGEAGVSARVYPALIDENHPLASVHGSFNAVFVKAEAADDLMFYGRGAGGAPTASAVVGDVVTEARHIAAGCTGPSIPLYKNLPKAPITASKAAFAVRFLIHDKPGVLAAIAAEFAKNGVSINGVNQDLKPTMTDPGYDGEIQQLRIVTHLTDEETLRNTVKAVQALDFVTGDPSILRVLD
>NC_014169.1|WP_013141370.1|2193555_2195148_-|diaminopimelate-decarboxylase
MPISPIWPAATTVNANGAIAFHGRTAESLLDKFGSPLYLIDTDEVSARAKHFVRAAAEAFNTSTTHVSFAGKAFLSKEIVRLVTEAGMFVDTCTMGEMKIALAAGVPGRRLVLHGNNKSDEEIALAIEQGFAKIVIDEPDEPERVAAIARKLGKRARVMLRVTVGVHAGGHEYISTAHEDQKFGVPLLAAGADAAVLDVLNALKDVTPAATNARISATHSPENGAEKTEKSERELHYDVKYPYDLSHEEVSDTDKALAAAMEAIADGPSIAVLKTILANQDVLELVGAHSHIGSNIHDADAFIHAAKRMMLLRKTLWATDAYILPEIDLGGGYSVAYTDGEDSMDIDVELTRLADAVNSTNRALGMPAPAISFEPGRYIVAPAGVTLYRVGAIKHVHLSDAKDSAGNPITERVYVSVDGGMSDNIRPALYGADYTARLANRTGSAETMLARVCGMHCESGDIVVHEVQLPADLKRGDILAVPVTGAYGRTMASNYNQALIPAVVAVSESGAHVMLRRQTVDDLLNLDVSE
>NC_014169.1|WP_038426192.1|2195150_2197013_-|arginine--tRNA-ligase
MSPEALSELISSIAHNLVAAGQAGALTDELIPPVDKLAVMRPKDRAHGDWASNIAMQLAKKAGMKPRDLAEPFAAALAEADGIAKVEVAGPGFINITLDSASAAAVVDTVLAAGAVTDTDKHLNKVNEYGRNAHLGGQTLNLEFVSANPTGPIHIGGTRWAAVGDAMARVLEANGAKVVREYYFNDHGEQINRFAKSLVAAWAEANNLGEAGYQTETPCDGYKGAYINEIAARVQAEAESDGVDLTALAHQDQGLNDDGEPLGEADTEVREEFRKRAVPMMFDEIQKSMKDFRVNFDVWFHENSLYADGKVDAAIEELKSRGDIFDKDGATWFESTKHGDDKDRVIIKSNGEFAYFAADIAYYWDKRHRAENPADVAIYMLGADHHGYIGRMMAMCAAFGDEPGKNMQILIGQLVNVMKDGKPVRMSKRAGNVVTIDDLVSVVGVDAARYSLARSDYNQNFDIDLALLASHTNDNPVYYVQYAHARSKNVDRNAAVAGISYEGADLALLDTEADGEVLAALAQFPSVLATAADDRQPHKVARYLEELAATYHKWYNVERVVPMALTDPETRGDDEARKALEIAKNPEPARAAARLKLNDAVQQVIANGLDLLGVTAPEKM
>NC_014169.1|WP_029680412.1|2197101_2198034_+|LysR-family-transcriptional-regulator
MAGLNPQSLVTLWQIEQYGSFSATAKATGWSQPAISQQIKKLEAQCGSTLVQRTSHGVELTATGSMLARHGEAIADRLERAAREVEDYRHHRFAHLHLVAPPSICSTIAARTVVKLSMFTDIELSLIQMEPPEAIGLISQGKADAAAVFRYSSIPNFLHIGDDLTFQSLGYDPMRLLVRRSSDIAKRFEETGEPVPLSAAKDEHWIAGCPTCRANLVKLATRAGFKPDIRHCTDDYWATQNLVEVGMGVSLVPALDTHINLQGDLVACPIADDFAAREVGIVTRAGDHRPALGSLLEELERTSLKYLSAK
>NC_014169.1|WP_013141373.1|2198127_2199381_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MSMNNVSQSTTLSSATAGASCFDANHIDVTTIEDLEQVGSDKWTRYPGCIGAFIAEMDYGLAPCVAEAIEEATERGALGYIPDPWKKEVARSCAAWQRRYGWDVDPTCIRPVPDVLEAFEVFLREIVRAGNSIVVPTPAYMPFLSVPRLYGVEVLEIPMLCEGAGESSGRNDEWLFDFDAIEQAFANGCHAFVLCNPHNPIGKVLTREEMLRLSDLAAKYDVRIFSDEIHAPFVYQGHTHVPFASINRQTAMQAFTSTSASKSFNIPGTKCAQVILTNPDDLELWMRNAEWSEHQTATIGAIATTAAYDGGAAWFEGVMAYIERNIALVNEQMRTRFAKVRYVEPQGTYIAWLDFSPLGIDDPADYFFKKANVALTDGRECGEVGHGCVRMNFAMPYPLLKECFDRMAAALEADGLL
>NC_014169.1|WP_007056295.1|2199426_2200752_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MAENPDDVLHVEGGKPLNGTIKVRGAKNFVSKAMVAALLAPGKSVLKNVPEIRDVHVVSDLLRLHGVDVDVDGANGIVTIDASRVQLADVADVDTLSGSSRIPILFSGPLVHRLGEAFIPALGGCAIGGRPIDFHLETLRKLGATVDKEHKDGIHITAPNGLHGAKIHLPYPSVGATEQTLLAAVLAEGKTELSGAATEPEIMDLVCVLQKMGAIISVDVDRTFRIEGVKELQGYTHTSLTDRIEAASWASAALATHGDIFVKGATQPEMITFLNVFRKVGGKFEVTDKGIRFWHPGGDLKPVAIETDVHPGFMTDWQQPLVVALTQANGLSIVHETVYENRFGFTKPLVEMGATIQLYRECLGSLPCRFRQRNYKHSAVIFGPTPLTGRDIDVPDLRGGFSHLIAALAASGPSDVHGISLIDRGYADFRGKLEALGADFD
>NC_014169.1|WP_007053081.1|2201001_2202348_+|FAD-dependent-oxidoreductase
MTTVAVIGCTHAGTFATTSILAEHPDWTVHVFERNGTLSFLSCGIALWVGDHVSDPKKMFYSSPAALAEAGATMHMRTDVTSVDLDARTLTYRALDEAGDPAEQTLAFDKLVVTTGSRPVIPPIPGIDSPHVLLCKNWDHAIAIKEKAKTAKSAVVIGSGYIGAEIAEQFSVTGVKTTLVDGLDRPLANNFDKTITDQVAAAFEEHGVTLALGQKVVEFRDNDDDTVTVVTEKGEYTAEMAILAVGFLPNTDLLKGKVDMLPNGAIVVDDYMQASAPGVYAAGDSATVFYNPTGQHDYIPLATNAVRQGLLVGRNIETPTVKYMGTQATSAVQLYDLSLAASGLTRAGAERRGLTVRETSLTEDYRPDFMLTTTPVTSILTWDPETRKVKGGQFCSKADISGAANVISMAIQAGFTIDQLANVDFLFQPNFDKPVYYVGAVAMKAAAE
>NC_014169.1|WP_013141374.1|2202551_2203679_-|diguanylate-cyclase
MSDFEPFYDVSRSYEDNYEQGPFGAFAEALKDGNGADAAGTTSEGASEGALATFLGQPVNLPFGIPAGPLLNSRFTTAAFHMGFDLATYKTVRSRAWGCNPFPNVLAVHPKSADGSLTPGSAELDEGVLADTNYEQPISISNSFGVPSQSPDVWQPDMRAAIEAAGPGQVLVPSFQGSRVEGMSEEEYIADHATTARLVKETGAKLMVMNTSCPNEGHNRLLCHNPLLVGRITEAVKQEIGDIPLMVKLAYIPSDDALELMVRSTVGHGTVQGFSTINTISAKLVDANGNQALPGAGRDHSGVCGNAIRGAGLDMVARLAAIREKLGLDFAINGVGGVVSPADYQAYRNAGADSVMSATGAMWDAELAHKIKASR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014169_1	1.1\|321277\|34\|NC_014169\|CRISPRCasFinder	321277-321310	34	MH051917	Enterobacteria phage vB_EcoM_IME341, complete genome	77783-77816	9	0.735
NC_014169_1	1.1\|321277\|34\|NC_014169\|CRISPRCasFinder	321277-321310	34	NC_014260	Enterobacteria phage IME08, complete genome	96611-96644	9	0.735
NC_014169_1	1.1\|321277\|34\|NC_014169\|CRISPRCasFinder	321277-321310	34	MT150133	Enterobacteria phage vB_EcoM_IME540, complete genome	143362-143395	9	0.735
NC_014169_1	1.1\|321277\|34\|NC_014169\|CRISPRCasFinder	321277-321310	34	MK234886	Escherichia phage AnYang, complete genome	65312-65345	9	0.735
NC_014169_1	1.1\|321277\|34\|NC_014169\|CRISPRCasFinder	321277-321310	34	HM071924	Enterobacteria phage IME08, complete sequence	96611-96644	9	0.735

1. spacer 1.1|321277|34|NC_014169|CRISPRCasFinder matches to MH051917 (Enterobacteria phage vB_EcoM_IME341, complete genome) position: , mismatch: 9, identity: 0.735

atttgtagggaaatcctccagttcaaattcgtta	CRISPR spacer
acctccaaacaaatccaccagttcaacttcgtta	Protospacer
*..* .*.. ****** ********* *******

2. spacer 1.1|321277|34|NC_014169|CRISPRCasFinder matches to NC_014260 (Enterobacteria phage IME08, complete genome) position: , mismatch: 9, identity: 0.735

atttgtagggaaatcctccagttcaaattcgtta	CRISPR spacer
acctccaaacaaatccaccagttcaacttcgtta	Protospacer
*..* .*.. ****** ********* *******

3. spacer 1.1|321277|34|NC_014169|CRISPRCasFinder matches to MT150133 (Enterobacteria phage vB_EcoM_IME540, complete genome) position: , mismatch: 9, identity: 0.735

atttgtagggaaatcctccagttcaaattcgtta	CRISPR spacer
acctccaaacaaatccaccagttcaacttcgtta	Protospacer
*..* .*.. ****** ********* *******

4. spacer 1.1|321277|34|NC_014169|CRISPRCasFinder matches to MK234886 (Escherichia phage AnYang, complete genome) position: , mismatch: 9, identity: 0.735

atttgtagggaaatcctccagttcaaattcgtta	CRISPR spacer
acctccaaacaaatccaccagttcaacttcgtta	Protospacer
*..* .*.. ****** ********* *******

5. spacer 1.1|321277|34|NC_014169|CRISPRCasFinder matches to HM071924 (Enterobacteria phage IME08, complete sequence) position: , mismatch: 9, identity: 0.735

atttgtagggaaatcctccagttcaaattcgtta	CRISPR spacer
acctccaaacaaatccaccagttcaacttcgtta	Protospacer
*..* .*.. ****** ********* *******

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

368139 : 434483

Thermus_phage(15.38%)

protease,tRNA,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013140178.1\|368139_369183_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_013140179.1\|369221_370019_-	mechanosensitive ion channel	NA	NA	NA	NA
WP_013140180.1\|370098_371532_-	aspartate ammonia-lyase	NA	NA	NA	NA
WP_013140181.1\|371650_372382_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_038425864.1\|372472_373879_-	DUF2974 domain-containing protein	NA	NA	NA	NA
WP_013140183.1\|374200_374752_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	5.6e-19	37.3
WP_007057690.1\|375216_375384_-	hypothetical protein	NA	NA	NA	NA
WP_080515122.1\|376063_377224_-\|transposase	IS256-like element ISBlo16 family transposase	NA	NA	NA	NA
WP_007057699.1\|377601_377826_+	hypothetical protein	NA	NA	NA	NA
WP_080515123.1\|378239_378449_-	Vacuole effluxer Atg22 like protein	NA	NA	NA	NA
WP_007054783.1\|378688_378853_+	hypothetical protein	NA	NA	NA	NA
WP_013140188.1\|378849_379035_+	hypothetical protein	NA	NA	NA	NA
WP_013140189.1\|379413_380484_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_003829805.1\|380502_380691_-	hypothetical protein	NA	NA	NA	NA
WP_013140191.1\|380950_381274_+	type II toxin-antitoxin system RelB/DinJ family antitoxin	NA	NA	NA	NA
WP_013140192.1\|381263_381653_+	hypothetical protein	NA	NA	NA	NA
WP_013140193.1\|381831_382575_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_013140194.1\|382755_384033_-	MFS transporter	NA	NA	NA	NA
WP_013140195.1\|384256_385273_-	sugar kinase	NA	NA	NA	NA
WP_007051452.1\|385643_385838_+	50S ribosomal protein L28	NA	NA	NA	NA
WP_029680011.1\|385949_388571_+	ATP-dependent DNA helicase RecG	NA	NA	NA	NA
WP_013140197.1\|388705_389749_-	LacI family DNA-binding transcriptional regulator	C6ZCU4	Enterobacteria_phage	2.8e-27	26.0
WP_013140198.1\|390107_391019_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_013140199.1\|391018_391996_+	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_038425867.1\|392114_393506_+	carbohydrate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013140201.1\|393596_394874_+	fuconate dehydratase	Q6A202	Oenococcus_phage	1.8e-12	23.7
WP_013140202.1\|394889_395681_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_013140203.1\|395824_396721_+	dihydrodipicolinate synthase family protein	NA	NA	NA	NA
WP_013140204.1\|396756_397194_+	L-fucose mutarotase	NA	NA	NA	NA
WP_013140205.1\|397213_398650_+	alpha-L-fucosidase	NA	NA	NA	NA
WP_013140206.1\|398665_401017_+	glycoside hydrolase family 95 protein	NA	NA	NA	NA
WP_013140207.1\|401160_401772_+	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	NA	NA	NA	NA
WP_013140209.1\|401795_402611_-\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA
WP_038425868.1\|402684_404331_+	U32 family peptidase	Q6DW11	Phage_TP	3.8e-39	35.8
WP_013140210.1\|404409_405390_+	laccase domain-containing protein	NA	NA	NA	NA
WP_013140211.1\|405469_406345_+	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_013140212.1\|406354_407032_+	pyroglutamyl-peptidase I	NA	NA	NA	NA
WP_013140213.1\|407179_408748_+	cell division protein	NA	NA	NA	NA
WP_013140214.1\|408862_410206_+	C1 family peptidase	R4TV59	Phaeocystis_globosa_virus	2.5e-60	31.8
WP_179287629.1\|410559_411648_+	3-deoxy-7-phosphoheptulonate synthase	A0A0B6VT43	Edwardsiella_phage	2.3e-80	44.4
WP_185967054.1\|411948_413010_+	3-deoxy-7-phosphoheptulonate synthase	S4W5F1	Pandoravirus	8.6e-85	47.1
WP_013140218.1\|413163_413751_+\|transposase	IS607 family transposase	F9VHY9	Thermus_phage	2.8e-24	37.6
WP_013140219.1\|413743_415048_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A7P9	Microcystis_virus	1.1e-36	35.5
WP_013140220.1\|415109_415823_+	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	NA	NA	NA	NA
WP_013140221.1\|416095_417409_+	MHS family MFS transporter	NA	NA	NA	NA
WP_013140222.1\|417633_418965_+	two-component sensor histidine kinase	NA	NA	NA	NA
WP_029680021.1\|419163_419868_+	response regulator transcription factor	W8CYM9	Bacillus_phage	3.3e-40	38.2
WP_013140224.1\|420105_421239_+	phosphate ABC transporter substrate-binding protein PstS	NA	NA	NA	NA
WP_007051435.1\|421449_422403_+	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
WP_010081151.1\|422402_423401_+	phosphate ABC transporter permease PstA	NA	NA	NA	NA
WP_007051433.1\|423453_424233_+	phosphate ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.3e-13	32.3
WP_013140225.1\|424529_425108_+	LemA family protein	NA	NA	NA	NA
WP_012471992.1\|425171_427442_+	DUF2207 domain-containing protein	NA	NA	NA	NA
WP_187287448.1\|430071_430242_+	hypothetical protein	NA	NA	NA	NA
WP_013140228.1\|430449_431313_+	aldo/keto reductase	NA	NA	NA	NA
WP_013140229.1\|431404_432460_+	nucleoside hydrolase	NA	NA	NA	NA
WP_013140230.1\|432598_433186_+\|transposase	IS607 family transposase	F9VHY9	Thermus_phage	2.3e-23	37.0
WP_013140231.1\|433178_434483_+\|transposase	transposase	Q19ZT4	Mycobacterium_virus	3.6e-40	33.9

DBSCAN-SWA_2

893095 : 906002

Gordonia_phage(33.33%)

integrase,transposase

attL 894178:894237|attR 897569:897667

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_038425912.1\|893095_893611_+\|transposase	IS3 family transposase	NA	NA	NA	NA
894178:894237	attL	NA	NA	NA	NA
WP_013140284.1\|894272_895328_-\|integrase	tyrosine-type recombinase/integrase	A0A2K9VH95	Gordonia_phage	5.5e-07	27.1
WP_038425874.1\|895324_896290_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_013140282.1\|896286_897489_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_013140531.1\|898044_899211_-	histidine kinase	NA	NA	NA	NA
897569:897667	attR	NA	NA	NA	NA
WP_012576686.1\|899222_899825_-	response regulator transcription factor	NA	NA	NA	NA
WP_038425915.1\|900360_901287_+	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	9.7e-16	28.3
WP_048349542.1\|901283_902054_+	hypothetical protein	NA	NA	NA	NA
WP_003828120.1\|902055_902760_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	9.6e-24	31.0
WP_003828119.1\|902785_903478_+	hypothetical protein	NA	NA	NA	NA
WP_080515122.1\|903986_905147_+\|transposase	IS256-like element ISBlo16 family transposase	NA	NA	NA	NA
WP_038425912.1\|905486_906002_+\|transposase	IS3 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

2270899 : 2359419

Bacillus_phage(25.0%)

integrase,tRNA,transposase

attL 2301381:2301397|attR 2359672:2359688

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013141415.1\|2270899_2271955_-\|integrase	tyrosine-type recombinase/integrase	A0A2K9VH95	Gordonia_phage	9.4e-07	27.1
WP_038425874.1\|2271951_2272917_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_013140282.1\|2272913_2274116_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_148217417.1\|2274246_2275314_-\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.3e-08	26.9
WP_013141418.1\|2276053_2277010_-	TatD family hydrolase	NA	NA	NA	NA
WP_038841046.1\|2277020_2278595_-	MFS transporter	NA	NA	NA	NA
WP_013141420.1\|2278631_2280992_-	alpha-L-arabinofuranosidase	NA	NA	NA	NA
WP_038426200.1\|2281057_2282428_-	glycoside hydrolase family 27 protein	NA	NA	NA	NA
WP_013141422.1\|2282732_2283803_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_013141423.1\|2283911_2284949_+	glycoside hydrolase family 43 protein	NA	NA	NA	NA
WP_013141424.1\|2285159_2285903_-	hypothetical protein	NA	NA	NA	NA
WP_013141425.1\|2285931_2288088_-	glycoside hydrolase family 127 protein	NA	NA	NA	NA
WP_013141426.1\|2288134_2290198_-	hypothetical protein	NA	NA	NA	NA
WP_013141427.1\|2290220_2291291_-	glycoside hydrolase family 43 protein	NA	NA	NA	NA
WP_013141428.1\|2291338_2292253_-	family 43 glycosylhydrolase	NA	NA	NA	NA
WP_080515236.1\|2292301_2295052_-	beta-galactosidase	NA	NA	NA	NA
WP_013141430.1\|2295195_2296158_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_038426201.1\|2296185_2297154_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_013141432.1\|2297227_2298844_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_148217418.1\|2299154_2300270_+	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_013141434.1\|2300274_2300955_+	DUF624 domain-containing protein	NA	NA	NA	NA
WP_013141435.1\|2301032_2302820_-	ABC transporter ATP-binding protein	A0A1V0SJ29	Klosneuvirus	1.8e-13	22.3
2301381:2301397	attL	NA	NA	NA	NA
WP_038426043.1\|2302830_2304741_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.1e-48	28.1
WP_013141437.1\|2305182_2306580_+	ATP-binding protein	NA	NA	NA	NA
WP_013141439.1\|2307440_2308421_-	family 43 glycosylhydrolase	NA	NA	NA	NA
WP_025301488.1\|2308541_2309375_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_013141440.1\|2309420_2310380_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_013141441.1\|2310542_2311790_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_013141442.1\|2312066_2313113_-	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_050569365.1\|2313388_2315500_+	beta-galactosidase	NA	NA	NA	NA
WP_013141444.1\|2315574_2316945_-	ATP-binding protein	NA	NA	NA	NA
WP_038426044.1\|2317266_2318688_+	MFS transporter	NA	NA	NA	NA
WP_013141446.1\|2319057_2320791_-	ABC transporter family substrate-binding protein	NA	NA	NA	NA
WP_013141447.1\|2320822_2322961_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.8e-17	31.4
WP_038426205.1\|2322978_2323929_-	ABC transporter permease	NA	NA	NA	NA
WP_013141449.1\|2324001_2324985_-	ABC transporter permease	NA	NA	NA	NA
WP_013141450.1\|2325278_2326808_+	aminopeptidase	R4TV59	Phaeocystis_globosa_virus	6.4e-65	30.9
WP_038426045.1\|2327084_2328170_+	hypothetical protein	NA	NA	NA	NA
WP_013141452.1\|2328635_2328932_-	hypothetical protein	NA	NA	NA	NA
WP_013141453.1\|2329349_2331215_-\|tRNA	methionine--tRNA ligase	A0A2K9KZR3	Tupanvirus	1.2e-65	29.6
WP_038426046.1\|2331580_2332228_+	hypothetical protein	NA	NA	NA	NA
WP_013141455.1\|2332224_2332596_+	hypothetical protein	NA	NA	NA	NA
WP_013141456.1\|2332622_2333633_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	6.6e-42	36.7
WP_013141458.1\|2334179_2335598_-	MFS transporter	NA	NA	NA	NA
WP_038426048.1\|2335752_2336799_+	FAD:protein FMN transferase	NA	NA	NA	NA
WP_013141459.1\|2336937_2338767_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	7.2e-47	29.5
WP_013141460.1\|2338981_2340853_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.0e-32	26.4
WP_007052942.1\|2341039_2341561_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_007055052.1\|2341922_2342486_+	hypothetical protein	A0A2H4J297	uncultured_Caudovirales_phage	5.0e-23	42.3
WP_013141462.1\|2342981_2346818_-	bacterial Ig-like domain-containing protein	NA	NA	NA	NA
WP_013141463.1\|2347029_2351571_-	bacterial Ig-like domain-containing protein	NA	NA	NA	NA
WP_013141464.1\|2351874_2353371_-	putative DNA binding domain-containing protein	NA	NA	NA	NA
WP_013141465.1\|2353710_2355234_-	amino acid permease	NA	NA	NA	NA
WP_013141466.1\|2355559_2356765_-	ROK family transcriptional regulator	NA	NA	NA	NA
WP_187287445.1\|2356956_2357478_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_050749730.1\|2357648_2357975_+	hypothetical protein	NA	NA	NA	NA
WP_080515312.1\|2358108_2359419_+\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	8.1e-08	23.0
2359672:2359688	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014169

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection