CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_016582	Streptomyces bingchenggensis BCW-1, complete sequence	20 crisprs	csa3,WYL,RT,c2c9_V-U4,DEDDh,DinG,cas3,Cas14u_CAS-V,cas4	6	11	7	0

1. NC_016582

CRISPR-Cas detection and classification

Crispr_ID: NC_016582_1

• CRISPR_ID: NC_016582_1
• CRISPR_location: 725592-726086
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 8 spacers

Consensus repeat of NC_016582_1

Consensus_repeat	Method
GCNTCNNNCTNCTTCTGNTCCTGCTCCTNCTNCTTCNNNTCN	CRT

spacers of NC_016582_1

>1.1|725628|18|NC_016582|CRT
GCCTCTTTCTCCTTCTGT
>1.2|725682|18|NC_016582|CRT
GCCTCCTTCTCCGCCTCC
>1.3|725736|45|NC_016582|CRT
TGCTTGGCCTCCTGCTCCGCCTGCTTCTGCTCAGCCTCCTTCTCC
>1.4|725817|18|NC_016582|CRT
TGCTCCTGCTCGGCCTCA
>1.5|725871|18|NC_016582|CRT
GCCGCAGCCTTGGCTTCG
>1.6|725925|18|NC_016582|CRT
GCCGCAGCCTTGGCTTCG
>1.7|725979|18|NC_016582|CRT
TGCTCCTGCTCGGCCTCA
>1.8|726033|18|NC_016582|CRT
GCCGCAGCCTTGGCTTCG

CRISPR arrays and Neighbor proteins around NC_016582_1

CRISPR arrays

The CRISPR arrays of NC_016582_1

>merge|NC_016582|1|725592-726086|CRT
TCCTGCTTCTTCTGCTGCTCCTCCTGCTTGGCCTCGGCCTCTTTCTCCTTCTGTTCCTGCTTGGCCTCCTGCTCCGCCTGCTTCTGCTCAGCCTCCTTCTCCGCCTCCGCCTGCTTCTGCTCCTGCTCCTGCTGCTGCTGTTCCTGCTTGGCCTCCTGCTCCGCCTGCTTCTGCTCAGCCTCCTTCTCCGCCTCGGCCTGCTTCTGCTCCTGCTCCTTCTCCTTCTGCTCCTGCTCGGCCTCAGCCTCGGCCTGCTTCTGTTCCTGCTCCTTCTCCTTCGCCGCAGCCTTGGCTTCGGCTTCCTTCTCCTTCTGTTCCTGCTCCTTCTCCTTCGCCGCAGCCTTGGCTTCGGCTTCCTTCTCCTTCTGTTCCTGCTCCTTCTCCTTCTGCTCCTGCTCGGCCTCAGCCTCGGCCTGCTTCTGTTCCTGCTCCTTCTCCTTCGCCGCAGCCTTGGCTTCGGCTTCCTTCTCCTTCTGTTCCTGCTCCTTCTCCTTC

>NC_016582|1|1|725592-726086|CRT
TCCTGCTTCTTCTGCTGCTCCTCCTGCTTGGCCTCG	GCCTCTTTCTCCTTCTGT
TCCTGCTTGGCCTCCTGCTCCGCCTGCTTCTGCTCA	GCCTCCTTCTCCGCCTCC
GCCTGCTTCTGCTCCTGCTCCTGCTGCTGCTGTTCC	TGCTTGGCCTCCTGCTCCGCCTGCTTCTGCTCAGCCTCCTTCTCC
GCCTCGGCCTGCTTCTGCTCCTGCTCCTTCTCCTTC	TGCTCCTGCTCGGCCTCA
GCCTCGGCCTGCTTCTGTTCCTGCTCCTTCTCCTTC	GCCGCAGCCTTGGCTTCG
GCTTCCTTCTCCTTCTGTTCCTGCTCCTTCTCCTTC	GCCGCAGCCTTGGCTTCG
GCTTCCTTCTCCTTCTGTTCCTGCTCCTTCTCCTTC	TGCTCCTGCTCGGCCTCA
GCCTCGGCCTGCTTCTGTTCCTGCTCCTTCTCCTTC	GCCGCAGCCTTGGCTTCG
GCTTCCTTCTCCTTCTGTTCCTGCTCCTTCTCCTTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014173164.1|663229_663964_-|type-VII-secretion-system-associated-protein	unknown	unknown	unknown
NC_016582.1|WP_148276896.1|658664_660011_-|RICIN-domain-containing-protein	unknown	unknown	gnl|CDD|238092
NC_016582.1|WP_043488688.1|723239_723704_-|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl|CDD|376829
NC_016582.1|WP_014173160.1|657631_658252_-|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl|CDD|183245
NC_016582.1|WP_014173163.1|660032_663233_-|hypothetical-protein	unknown	unknown	gnl|CDD|223021
NC_016582.1|WP_014173167.1|722829_723243_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_043486022.1|688136_722825_-|lonely-Cys-domain-containing-protein	unknown	unknown	gnl|CDD|380151
NC_016582.1|WP_014173173.1|727700_728189_-|type-VII-secretion-system-associated-protein	unknown	unknown	unknown
NC_016582.1|WP_106436516.1|742009_742675_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|188483
NC_016582.1|WP_014173176.1|729251_730703_-|type-VII-secretion-protein-EccB	unknown	unknown	gnl|CDD|368288
NC_016582.1|WP_014173165.1|664014_666369_-|hypothetical-protein	unknown	unknown	gnl|CDD|380151
NC_016582.1|WP_014173175.1|728701_729037_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_148276897.1|666326_681947_-|lonely-Cys-domain-containing-protein	unknown	unknown	gnl|CDD|380151
NC_016582.1|WP_078610286.1|737240_738497_-|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|274856
NC_016582.1|WP_106436514.1|732555_736476_+|type-VII-secretion-protein-EccCa	unknown	unknown	gnl|CDD|274858
NC_016582.1|WP_014173174.1|728298_728616_-|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
NC_016582.1|WP_014173177.1|730735_732136_-|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl|CDD|274855
NC_016582.1|WP_043486024.1|738640_741958_+|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl|CDD|163057
NC_016582.1|WP_014173169.1|723777_724728_-|hypothetical-protein	unknown	unknown	gnl|CDD|369261
NC_016582.1|WP_106436515.1|736601_736787_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_148276896.1|658664_660011_-|RICIN-domain-containing-protein	gnl|CDD|238092	cd00161, RICIN, Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ligand binding occurs on exposed surfaces of the compact domain sturcture.	2.81181e-14
NC_016582.1|WP_043488688.1|723239_723704_-|YbaB/EbfC-family-nucleoid-associated-protein	gnl|CDD|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	4.24233e-05
NC_016582.1|WP_014173160.1|657631_658252_-|threonylcarbamoyl-AMP-synthase	gnl|CDD|183245	PRK11630, PRK11630, threonylcarbamoyl-AMP synthase.	8.55572e-76
NC_016582.1|WP_014173163.1|660032_663233_-|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	5.69178e-15
NC_016582.1|WP_043486022.1|688136_722825_-|lonely-Cys-domain-containing-protein	gnl|CDD|380151	NF012197, lonely_Cys, lonely Cys domain-containing protein. This model describes an unusual domain, over 700 amino acids long, that is largely restricted to the Streptomyces (prodigious producers of natural products) and that may occur ten or more times in giant proteins. The most striking feature is an extremely low cysteine composition, one residue per domain, and that in an essentially invariant position.	0
NC_016582.1|WP_014173176.1|729251_730703_-|type-VII-secretion-protein-EccB	gnl|CDD|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	5.07087e-137
NC_016582.1|WP_014173165.1|664014_666369_-|hypothetical-protein	gnl|CDD|380151	NF012197, lonely_Cys, lonely Cys domain-containing protein. This model describes an unusual domain, over 700 amino acids long, that is largely restricted to the Streptomyces (prodigious producers of natural products) and that may occur ten or more times in giant proteins. The most striking feature is an extremely low cysteine composition, one residue per domain, and that in an essentially invariant position.	1.94371e-36
NC_016582.1|WP_106436516.1|742009_742675_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	4.0141e-08
NC_016582.1|WP_148276897.1|666326_681947_-|lonely-Cys-domain-containing-protein	gnl|CDD|380151	NF012197, lonely_Cys, lonely Cys domain-containing protein. This model describes an unusual domain, over 700 amino acids long, that is largely restricted to the Streptomyces (prodigious producers of natural products) and that may occur ten or more times in giant proteins. The most striking feature is an extremely low cysteine composition, one residue per domain, and that in an essentially invariant position.	0
NC_016582.1|WP_078610286.1|737240_738497_-|S8-family-serine-peptidase	gnl|CDD|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	6.69901e-54
NC_016582.1|WP_106436514.1|732555_736476_+|type-VII-secretion-protein-EccCa	gnl|CDD|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NC_016582.1|WP_014173174.1|728298_728616_-|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.68474e-10
NC_016582.1|WP_014173177.1|730735_732136_-|type-VII-secretion-integral-membrane-protein-EccD	gnl|CDD|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	5.47551e-37
NC_016582.1|WP_043486024.1|738640_741958_+|right-handed-parallel-beta-helix-repeat-containing-protein	gnl|CDD|163057	TIGR02881, Stage_V_sporulation_protein_K, stage V sporulation protein K. Members of this protein family are the stage V sporulation protein K (SpoVK), a close homolog of the Rubisco expression protein CbbX (TIGR02880) and a members of the ATPase family associated with various cellular activities (pfam00004). Members are strictly limited to bacterial endospore-forming species, but are not universal in this group and are missing from the Clostridium group. [Cellular processes, Sporulation and germination].	1.31229e-84
NC_016582.1|WP_014173169.1|723777_724728_-|hypothetical-protein	gnl|CDD|369261	pfam07202, Tcp10_C, T-complex protein 10 C-terminus. This family represents the C-terminus (approximately 180 residues) of eukaryotic T-complex protein 10. The T-complex is involved in spermatogenesis in mice.	0.00392487

Protein sequences

>NC_016582.1|WP_014173169.1|723777_724728_-|hypothetical-protein
MSHDLITGPVNGDDSLHNPGGSESHIDSHGRVVTEYPDGHTTTIDPDNQTSSITTPDGHTRSGPLNVDNVLNNPDGSRSHIDPQGQVVTEYPDGSKTTIDPDTGGTSITDPDGKSVTGHLNGSGNSLPDFQQQSPGSNFGNIGGGGSGNSNSLYDPSSYEEELWDKDPYQSPGDQNGNGNNQAAANAGNQNQSGAPMGGGMPLNPGTMPGRGGGGGGGEGGPSERVRNVIDSGDVVSNRRATPRPGRPGGGLLDERENVITSGGTPFMPPMGGAGGAGSPGQVATQTDDRERESWVPEDEDVWGSDEGGSPAVIGR
>NC_016582.1|WP_043488688.1|723239_723704_-|YbaB/EbfC-family-nucleoid-associated-protein
MNDPYAERIHQARAHLEATRAAIARAEQDLADHNVTARSRDRAVEVTIGPQGELSGLTFLDNKYLSMTGPQLAASVLEAAQRGRQQVAQRVMDTFRPLMAANPDVPGSRDIDVDWDRLFGSAFEGGRRAGGGRSSSDRLRDEIHEDPDVPGGRP
>NC_016582.1|WP_014173167.1|722829_723243_-|hypothetical-protein
MSDDTYDMNLGKMRGALNGLAGLGDRARVLEGQYLADHERYKLWNGDSSHPDDYYEKTQPDDEKTTQTLIGTIKSLGLAITAAHSALLESLDSVKAVHADVTELIEQQERIADDDSGYESDDSGYGSGDDESGGGKH
>NC_016582.1|WP_043486022.1|688136_722825_-|lonely-Cys-domain-containing-protein
MEEITYTPEEAMWIQILIGDKPIAARANLAWDSQDQFPDLADNLVEFIDSVRDALSDVANAFPKQVGDALTKAMEPLTGSYGSNGIGDLLGKLRMDLPNERAQQSMKIQQAHWEIIAEITMMLIELAALAAMSFFTGGASLSMAALVRARAALGILMAMQRLLNFFPIGGALLEAVQEMIEALVVNLAQLVINPPARRPNGIDGTNLRDSFFFGFMTGLFIDVFQGAAKYFKSGISDFFKKNFDKDIFGKFNRDFRNTFKDIDFNSPDLDHIFGKPGRVNNMAYDFVATFVSHGLGEGFAEVVVTGILHGNWAFKWETFVFSGTSAVAEMGAGNALGSGAGWLHGKAFPNGNIFTDFINKSYAIAALRDGAGSDSPADSGSDSGSGSRSGAGPDLPKSSLPITTSADIPTHGDNSSSYRDNDSLYEGISSLYEDNSSLYGDNSSLYGDNSSFTPGYRDSDTYSVDSYGSSNSSADSVFDDTASINSASSSDSVGSDIPEYNSSSALTGGGSSSSYVPHANFPAGKGFQTTSQSPPLNLPGSAGSNLPPTGSYSGGSGLTTPEGVEDFKGNKEFQTGPDGSPATSDFPNTSGLPGTSGSPNTPGLPGTSGLPNSSSLPAPPAAHTPTVSNPDAEFDGAFGENGESTPTGQNTSTGQNTGAVPPPVSHSGGQSPASTPHSSSSGQHSGSGTPQPGQGPRAEQQQPRPDTETFGGPSADSAIDADRDADTDSDTRPDTDPADRGESPATPAPPDQEEIDRARQDYEDALDSFRSAATDVDTIGERLDTGVGTSADTAAHQDAGHRAEQARGRMLDAAARLRGLGIDPHGDPYTPGQEGTPGQEGTEGNERSRHVPVVHRDDAQRQWIAQQVTPDDLPENPPLLDPDDDVAIAELNDAGVTPGPKQQTATALGMDRFPVRDLDLDLAPVDHVKLQMVRSDSWPAPLDETAANATRRIWQSAYTDFAGGIPGVPDGPEQLAAGRAWDKAVSLVLPLELHPVLADSRHAGRDFRDAVRQVAEHLLTHGPDAPSGVALADTLRTGLGLRQRLRGAPTKSSGPSAPPPPAPRVPTTSSTVAPAPEPGPVAPAPLSSVPTASGPADPSGPSDDESVAVGDARPDEEPTGRSAAEAVGPLPAPPAPGEGPPRVSHVPQVLRLAFGAQVAQDPRYGVMMRGLAALELARRGDARFGTGGLDLERIARGILHLRSSEPMTRGRYFEALSVAATAYRDGRAESLAAVAAYWSHKKAGVLGDASALTGPDDWFQGWNFTGQALDLLLDYVGRQDPDGLKLSPPPWQGPPYVLVVEPGSEEGLVVLRDGQGNSTEVPYEELAELVAHDPRRPAGAPVVLLMPEAGAGMRALPRLMAARLGERVWSTYGGLRFEPVGDGTSRRRVVLASVNPGSAPVGAWVPSDPGQLPDGPWEVTAADGSTFPDSDLEMFALPTSDGQRLTGLALLNARDMAAGESDLRNVSRIRHYADQFEYEGISTTGPLLPLPRSLTDAIVVVGDGEAGMPRKSTGRSHMVTSGELSAFLWRQIAASVPAHWPVWLVGRGLATLPEGADRLEYVPAAQDVATRLGRTALASEGKQIVRGNADTPYLANVYDTDNPKSGYREFPPEPWPPALSMWADVAGLPWDVPDREERVRRWVRALREVHGFDIDTNPRLAGEFQRLLLGFGALERQSLAQGVGPLTWAGLEQTAGEYAGQLGWDPTLSPYLLGQLLEAYRAAEAQETGEPPQPGAESQDMSGVLGLGPQDVSRVLGRGHQDGEVAFGPVREDESRLLGMSAEDRFRELSLLSPDERRKLASDPVWVDELRRALPGVEFAETAAQLMVVVQDGPGEPMADQPVSAGRVARARAARMLVNPKIAVALLKSGARVLVVPKDVAMTRLRRFRGYAGQPGWDTRRGVMDARAVAVPEENLLGEATSVPDAKNHADGYGTPDHEFAHALHVHALGDSDRKAIKNAYQAKLNPRRGVDPSDVEWPDGIRRDLDGDPVDNYSSENEYEYFAQAVNAYLGVNTGTDMNTGRPRNNGAAWVREHEPALLPIMRRLFGHYENLLDDAERKVVQDAYRAKLNPPRGFDPLHVRWPDGIRRDLAGNPTDNYSSTGESAYFAQAVNAYLGLNEGTDGYTGRSRNNGAAWIRRHEPALVPILERLFGRDPQGPGPANPREETRAENELWENFRAFWDEVEGVYRPQPHALTPAGPMASVPPVAQDTATTPAPGRRSGSAEDVGPLPAPPGEGSSRPRRRSSGVPQVLRAVFGARVAEDPQYEVMVRGFEVLEAGGPRSGIGEAALERIARGILRLGPAERMTRRWYAEALSVVAAAHRDGRAGSLAAVAAYRLQGTGLLGDASALVGPDGRFLGRNFTGQLLDLLLDTVGRQGPGGLSWTLPPWQGSPYVVVVEPGGEAGMVVVRDGQGNPSEVTYAELAELVKHDPRRPAGAPVVLLMPEAGAGLRRLPRLMADWIGGRVWSTYGGYRWEPAGDGTSRQRVVLAATRPGSTPVGAWLPSDPGQLLDGPRELTAADGTKFLDTDVHAFALPRSDGQRLIGVALFNPREMAQREEQLRNVSQIEHYFDHNEYVPGTGGHRNGAVRRLPRGLTDAFVVVVHSLGTQAAFPLASTGQNHMVWSQALSSFLKRQMATMSIPADWPVWLVGCGLGRLPVGADRLAYVSGAQVVGTRNRRTAFTSDARLDVFGNGNPPALAKADDPDTPVFQWQELPPEPLAETLSAWADRAGLPGDVADRATRVLRWVRAMREIHGIDIDSNPALAGLFEWLLQGFGALERQALARSMGPLTAAELERVAAGYAGQMGWDPTLNPNLLGHLLEAYRAAEPSSYGAHAAPPTSGSATPGSVGLPQPGAAGQGLPRAVVFGGVAGPVGQLGSRLLGMDRGERFLALSALSPDKRRKLASNPVWVDALRQGLPVVEFAETAAQLMVVVQDGPGEPLPDQPVSAGRVARARMARMLVNPQVAATLLKSGNRVVVVPKDVAMTALSAFRHLAGWQVSPADPRTWDLIRGAGGIRDTAVPEENLLGEFAVLPGTETQFDGYSTPDHEFAHTIHENALDDFDRLVIDAAYWAKLNPPPDVDPFDVEWPDGIRRTLAGKPAENYSSTNQHEYFAQVVNAYLGLNAGRDAYTGRPRNNGAAWVRKHEPALLPILERLFGHYENLLDDGERQVVRDAYRAKLNPPRSFDPLHVRWPDGIRRDLAGNPTDNYSSTSESAYFAQAVNAYLGLNAGTDAYTGRSRNNGVAWVRRHEPALVPILERLFGRDPQGPGPANPLVQTRAENRLWEDFRALWNDAEAENELWEGFRAFWDQVEEVYRPQPHAPAPFGPMALVAQHTATTPAPGGLLPEMETGTSDTDTSSDTSSDGGVDLSSEGGVSLPPPPAPGQDIEDLWSLHLFFGTGDMDHHSSDALIAAAGALRRLALAGAGRPGTSPDPLGRIHDLARRVLDLGADSEVDVGHFRRLGSLALAVPPDQLTSEAALASFRADMDAALGSDGDSDSDADGGRNSDADIEDPAPRDGADARRARPLTTTDYTVVDNRGDGVLFRRPGETRGDWRAPRAFDRRADPPEFAVSVQDHAEILATERPALRISADRTLAVEDSALGQQVFATAEAVARSSVQLARAGSGIRLEIDDDLSVILPTPDGGSRQLFRITPVFMTRTGESGESTTEVCRDFADQVSGGHPTSHLVLSDPRSGEVATAPVDASDGGETTGTHYLAEALARVADGETPPDAVRPEWAADVLRRDDRPMGGYDGPLPGQSYGSALSLAEPADPRRDALSDAGRRIGVNEHAWADVGEGYVMQAIAAPGADGRPSLEHNHAKPGEQPGGGRVGYHFLSVVLASEDGTHQISLENRARRSARADRRRAAIAANLNSLGPDKLRETAAELRQEIERQEAAGIDEYLAEVRDYRDLTLALIGAEQAQEAVSAAPEGSEERARAELALEVAINRAAFWLGKVEPVIPGERQWYMRMYAQRPGESVHDVYAGLLSEAPSRMVNPITGVVLRGHEADPVPITFASGVTEAPADAANIVRYPASVAARAGVWNTDHQLPLPRLEITYERGGRGSVKAGKARAAAIEALYRSHLDAELERLQEGSPGQHITADDFTVEVVEHRGGRSGTGPGLDTLTLTLDDRRGGPRQVATRGPGRPGMSAPALTPAPAPALVPDADRPGSTSVLTGPSTDSLRAIRPYDRESGGLDRPSEADERRLRDVFPVASDGAYQRFPDPRGAHFGLAAPVRKLNRRLPYNTLFTDAGGAPWVRRLNGGWADPARQLNCLDVARSALVSWFGRPTVAAPVQAAPVQAAGPNGRLEVERDSMQRTARWLGTGWRHHAEEPGTSARAATANAVRAVERRLGRGDAGRHGSAAILRFQRPNGTVHAVNAFNHEGRIDWVDGQYGRVSDRPLYEGHTFLSIEVGPDGRPIDPLPLSDGPGHQTTVRTPRGPERLPLPGALTAPSSPASTPEVTPPSTPSSTPAVAPTAARQAGPSTTRPPLHSELFLDTPSPHKSAVEGDRFAMRRRSATMPALRNTMAFPADQGPSHVKADRDAGRWRNPLRRIDTFGVFGRPGSAASPTRDSAPSPRPGSDQAREGLERVTSGSSLSGSSSQRAGLAHVQQPTPPFPGAQIDNELMDRRPPRVDHALLPPPVVQRVSNFADDSRMPAYVDGLLPFSTDGTPEEAEDALLAFGQGHPYLRGPDTAARAVIDLLGGEDEETRPVETKEPRHPARSGDIDVGVEHRLVRAMREQPHTFAGDGREFTYRAESGRLRTLRVRIRNYGAWERFADSTGPTKIDNQYRAKTTVGGSKVLSTTRQIGPAVPIGPLPFAFAAFGRLGMRFARSHDTAYTMQDDVVSQGETKADDHSHVHIDDVYYEVTVTDALPPRPAKEGVLGTRWRARPARTSAPDFTSGVSLRDGLGLRLADTLTETHETVRTPQRMQLGPESDYRAVTTVGYGPVEEIRNWAAKRVGAEPGSTAHDELSAFFSSGNFDQMADRLSRSMVPGKPLFAGDKKRTPLGAFVIPRVVPGRAVLADESDKAKLAQTGQLTAQNSRKQSRAHTLEFFGVVGPTFNLPVVDVLNLIPGFMEKIKPRLQFGPGGRRGHTRGRYMTVGGSGAVKSAIQSTKTATDLYRVEKTVYVLKTGDAEPTAFRTWSLDWMTHREARRLAGLDDGTTLAKRDGREPYAPAYLTEDHPPTLGMSRVVQFLYPDGRYTDRTASGDSPADTRLATITRQVVAALAREFPGMIAPLEDLGDPDDSRWRNHAHYQMVLHNVLTVYNALSSHHAMEGNLDTMRTTGLRVPLQDPGRFTRGHRDIWLDADMTGRRFEGTTDNLLTRSSPGVTNADGGRYGTQSTEATFEALFSTIDAGATDERGAPAHSVTAQFGYRGNWQERAETPFGSTASAEPSADTTEPAHLYSYDLSITVSTGGYWRFRSLLRGITSLGLLGTQLFVFRAPRRGLVPPIRAKVLLAVPAEHSPDTDPHAPGAANPYRGPDRVTQGTLSVRETRDLVDRAPTAPVHPQEPGPLDGQPHQTVSVLAPPHGEGIVDAVLEEASQGRWHLTYQGAPAHDAAVRPHQPQLLTANFDQTATPLGLRATGLFSKGPYLDWLATVVHRIRVTGLRALGRPEPVKASVTVGASTAMTGTQTKSAAHSAGVSFVYGQSHSAGPGLTGNYGAVWRPWVRSESESETVTRTVTTDTSWSNSDYQVLTAGDAEHQVAADVRSIGLLKPVGRLLLQKGRHRAGRWQRITGGWLGHIPERTAAEMGLIRDGLGAGPMYADRTWSLPGWLRRHPFAQYPVDSLNVTEALTAFDQKLDGLGHGLDSVSREAVRRLVSGRVARALRREMTGTGSSLPSRIGGPGWKRVRIGKRDVRVRARLIPVEDGQDFDRLWPGAELGESRTAVETRTRAFEQGRGSDAGTTITEGVRTDNPSVPTAGPSLAEFGSNRQIISGSSGITLTRARKTTTKGPHAQFTTRYRLELTLEIGRMRGEIPRDPDTSRISHEQDVGTLKDIIPLSLLRPDPADDGQPGAEPDPLRPPEPVDEPPAVNVLTSATDRIPSEQLWDRVRAWRSVPQPGGGEAPFEMPSNGFDVRAVIGAEGVEAAGLLALAKAYDNRLAQVSGQLTGDALEEALRWARLTPLTAEGTGAAQVLEDSSGNVALSTFAEDAAGDSGYHTAGITENNILDSATGNLARYMRPDLSGAQLLTVADGGDMEAALQHTHNDTANTNYGGVTDTAIGGFPLIKTQPLGTVNMGVSGTGANALEADGQAITNEQVHQTKVKPTTGRMFAFAIPTAWLTVAEVDRQLKDNSFAVWAREHLMGPFGGVKPGIQAVETQTQIIAWVREDVARQLGLITDENFPERVGTAWDKVSEAAKALTEADQEYWSLRRDVPDLHEAVTVAEAEYTRARRHRSAAERATRAADRSARHHYRAAEAAADETARGPAAEFREAVRDRLQAAEEEAAAKAQAVRDALWAQLLETTAGQPETGQTQPEAGQAEERWTAADQQLVQAREEQAAADRLVAGIRQDERDRLVTEARRMHDEVTDGAARRVVSADDAVQAAHHTLRTAERARDNRLAELAKQRTTAETAADTLHRLHGETSRLTRWHQLPDDPGSGEEGAVRTRAGVPEPRLTSGELTGREGTALLETVTEESEESPVYTPATVLADGSPALTSPEGTTHPLRDVPEDGKSFYHAFIAAHGGITDDADTLRSRFAEALAALPDDSPLLAYLVPDEKDTFSAAEVEAAGLDLGTGTPERREFDAFGVIPHSAGDLPTPDRRHQPLAPAQRRGLAAAQLRRLAAHVNKQTWDNAVADLLPALAARIHGIGVRVVRDDGSFLDYAPDPERPLPEDAPRVVVHLADERFRAVLPDEVAAGPAAPAPATPAKPPADDALPAHAHRPWTWEGLTDDESEPEPKYDAASDLNRLTDPDGYAHGLVAPPGDGNRFYAALAMAVNAAGLRLPDGGEYQPQDLSWSARLPLPSTARLDPRATFRAGELAVAGIGLTDDQRRQFERNGGRLPWLPLPLTRQQEEALIRAQLFAARRWNRPTALLAAELLASHLDLHLTLVHENGTIDTFGVAHENARNAVTVYERGDEYLAALPEGDRNPGAPRNHRTTKPPKPARRNTPPAIVVLPPDGPEGAKGEPKARPTGDGLGPRNEISPVQDTAAPPARSGEPAEPAEPAAVRPPDGPPAPAEDPARDDNLYDGDSYDGDRAPHDSAPYDSDPYAAALAEFDALSRLHGLSDPYAAHGPDTAREVLRRLDTLRAKVPGLADGPLDLDALARHVLAPDGYGPVTADERAELFRLALDAADNTPSLAVLAGLHLARQGVSGVWDHGGDADAFAARVLHLDRPDPERRGELYRLVNRARNAGRDIGSTVELGAFHLEREGMLGSHTLLRDTGDRAFGRHLDGPGKRGLDFDPSRVTLVRYRPDGTIDHGSSRPGPAPWHRPGGPAPWVIRARGDLGLDLLSGVVPPEDAAALLSHDPQVRALPPDAEIVWLLPDPDPAEQGDAVEGLLLATSLATGHRARTAYGEADIYENRDTGKLTLALGRDAAGRPHTADDWVSIAPVTNTPTVTDPAPVTDPVPVPAPRVWSRAELTALVDGMAEGLPPGGVSERRCLELLGALRDELHPGVLLPSGVRAGGVVDESVLDQGPRSRLVRGPGWGRVGSWGAVADALRDAEDAGRVGPGSVALVLARRPGSVSLERGRRPEDGLGHAFAVYHTADGVVWVDPSEREGRRVSDVPPRMVPFDARAVVVGPSGRVVADALQTFVESSSVAHAVLDGAVRDEYGALGPEFEYRYPLAIAPLPAELLRRLGISVPEPPNKPDLTKVLLAQGPGVKIVVDKAPLWRHPDFPMPFDMAAQVPPQSVRGSGAITEVVGDPAALVLGERWQSLEEARARRRLVRDRLARLGTIERGGRPVPLVKLLGDLPGWEITEVGRATTIYPLAPGHNGRTYAQFSLGTPAVGLRMLHDHALDRAWPRELLLLTTTGRDFGRWVAGKFASEVAGRGEVPVELVAFLSAIPDVDEAWGYAWRAFTHVAARPLTVTQPQLLKNWLAVASRHGFDSDRRALRPGTRGFLDERHDGLSAVAHDMLKVEMERHFRIFSPGGVVSDGFFDFVVRDPGETGDVPSPREQLTAALTGRTSQGRRIGSLESVGMDEFPALDTSGGRLLVALMVNEFRGYGFDDRTMTEEQIEQAEAELAELGRAMYERAVAASVPLSPDVLSRSVERILDDPVVRGFAPFVSLLVGGVPQVEGPNQRVLTMANGMAVAGALGRYALGHDRLSPDSPAYRLAAEALEKVAVLLTTGTVPVEERARVEGAVRSAEMALTAVRELPAPAAIEWPAEIEALDGTRVPVDQVSQVQHLNASGVQVGVSLRGAGPWRGRQQSYGLLPEVEHYTEVRWAPPEDRWDRASAVVAEGPRKKAPFGKVFLLGMDGDGTAAWLRVQPDQVSLDGMETDGLVVSFAYERAADYVFARVPALTAASWDTAVWWAGADVAGPYARGRDPLQWPVAGQVLSNRFDRWLWTSALGGEPGFATRREADGHGGQKQVTWLRLEEGDSLAGFRPEPSSVRLAVWAERVAGDRRRAGDVQRWWRAVRLVYGPLLEDDEAAFEALLRGFHALDQWRAGRGDASPLTWSGLLDVVNPYMDLVNAHVSESGQPPLVWWQALPFTLVSAAGEIGVELELSRLDLTPRHAPVRAWEQAPESPVAPRAGAADEPPGSPAPVRPASPRPIEPGPAGGLEQLPAARPLAVDSADSADSADQVFVPAWNAHAGAWTAFAEAATGAASAERAGRASGEDTLMADPDQEPDFWAGVERARERLEEAEARLWALGVPLDVTAGARGAATGEAAEAPVVPRGDAQRRWIAGELTEEDVDPVAARLAASATTGLAEADVRAAGVTPVYDQQAQIQMALRGDSGDNRVPVHALPPLELARVLMMRPGPWTDALDDVAANASRRLWASAYADFAGAAAGAAPGTALGGAMETDVARAWAAAVSLVLPVEPHAVLADSRYAGDGFRSVVRQVADHLLMWGPDTEAALRSAAELADILRLDLGLRRRWDVPAADGAGPGDSASRVFVAPVAPRAPASPAPLASQSPAPPAAAPAPGLPPLSVVEFTPDGTGPAELERQATAGITPSRDAVAVERLAALHDRDRRVRESAFDVDATARRVLHLPANAPVDQAVRAELFELVWAAEADGRADSLTALGAFHLDLLGVVGPGHSSYFTMEWSQIPGVSWLGPDVMGALGALELNMDRSDVLVPQPDGSLAAGGPRRKTPWPKGTVPCVIAGKRRGDMVVVRLPDDSTRDADVEELIELMAIAVARAGLPPGTPIVVVVPFLGQYGVFLQQFADRSGLEVWAHSGEVTVSAWSDGTGSIDTVAGRPGVPTGDWASFRPGQGPVLDESVPDWYRDVLMWPVVSEATEEETGYASFKPDEYARNFEKTERVSDRMTTFIHYSFPTNTEGPELELPRPGPEASPFSQADGFRLSAHAIPGYMVLAMRSGNGVVNRYVGEGQVVAWVKWLVSRRPKVRWIDFSDCWLGSPKDSDSRGPTMRSVFDPEVFVADPLREISVAHRTANATRLWARASYGQLSDGERPGTNVRRWALYSDSQGRPREIALERPDPEGAELDRLAAVARLHSGPGAVSAEVRERTLIAVRALKLMFGVYVEDGAGFGELLRGVAAVDEMWLADPEFRQVGPLTLDLLSRVIAAHAGAGVEVDQEVARRALAAAATAWEARPRGPRGERVDMAWDFVELPVVRLGAQWVLGDEAKSEAATALNLSSSGPLGEAERLRMLWAWVKTMDLLTAPGVDGDALTRRVLHLDPGFDVDPTERAEVRETLTRAFAVGRDASDTDVVAAYDREVFGAFDDTGIATVLDGVRGSGRDFTGESGPAVNLAQIHTPGGLVDAPWRNRNRNRRAAAFLPYLLRADLDQRDPDTIRLTIHDQVFELPVGEFSELTAVDRALTKRMNGAEVIFSHAEWAPDVGAVAKRLAQRLGRPVWWTEDPTDLSDTDDQGAPVLTAFASAASGPVWHLAVPEATAAPVPPAPHPVPRPYPLPGSTGPAAPTTTSATPALPSAASATPHGGAVRSAPPGPAGETGEAGEMPSAVTPLALSPDPAPYPDSAMDPVPVTDLAPVPATVTAADSVPRVLTRGELTGLVDGVAVSVPSGGVSERRCLELLDALRDELHPGGLLASGVRAGGVVDESVLDRPGAASRLVVGPGWGRVGSWGAVADALEKARLAGPGSVALVLARRPGSVSLEPGRRPEDGLGHAFAAYHTADGGVVWVDASKLKGRRVSEVPPEVGLLFDAQAVVIGPSGRVVVDALEPFVESAAVAHALLDGAVRDEYGALGPESEGSGGVAARGAPGVSGANGAGLWALAPKLVMSMRGGCISRFTAPVDPQTATPPVPLAVRTAVSPAERLLKALHGRDLRFRRGRFDVDVVARHVLHLPEGAPVDQAVRAELFGLVRAAKADGRAGSLAALGAFHLERLEAAGSARSGHFTRGGHRVPGLNWLGSDALKLNTDWSDVLTPQADGSLASGGPGGMTPWPKRQWPYVVGADWREDKKKVVVRLPDGSTRDAAVEEFVELVAADVARAKLPPGTPIVVAVPFLGRYGPLLQELAERTGLVVWPHSGEARVRPLPGGKGSIATVVGRPGVPKGAWVPLRPGQGPVFDESVPDWYRDVVMFPIVSEMTGGRMGDASFEPAEYAEDFEEGDRRLDQMTTYVDYRFALKLVSPEQDLPRPGPEGSPFPESSAYRISLHGVPGYMVLSVWSGDRVYNRFIDESEAVAWVKWLVSRLPWNRWIDFACCSLASPKDSDTPGPPAHGSLFDRKVFVADPLRELSLGQHMVNGARRWARVSYGQQTETKLSANGKYVRALFADAQGRARDWELPRPDPEGAELDRLAVVARLHSGSGPVSAEVRERTLIAVRALKLMFGVYAEDRADFGELLRGVAAVDEMWLADPEFRRVGPLTLDLLSRVIEARPEAASGVDQDVARRVLAAAAAWWDARPRGPQGGRVDMPWDFVDLPVVRLGAQWVRGGAARFEAANALSLFSSAPLGEAQRLRMLWAWVRTMDLLGKPGVDVDVLAVRVLHLDPSLPVGRAERENLRTLLTRAFAVGRDASDTDVAAAYHLEVNWAFAVTDRDTVLDGIRGNGRDFTGESWPRVNLAQIRTSGGLVDAPWRNRNRNRNRQAIELDLYLMRIELDPQDPNIIQLDIDGDVFWIPVSEFLELMANDSILLAKGRGTEVVFSHARPAPGIDEVARRLAQRLGRPVRWTDDPTDLSGKDDQGVPVLTASASAASGPVWQEAKVVFPTLPVPPAPRPVAEPLPKSAVAAAPATTPPPVTPPATTSATTTATTTAATVPSAAPATPHGGAVRSAPPGPAGETGEAGEMPSAVTPLALSPDPAPYPDPAMDPVPVTGMSTGPSAPRPSTAIRSPSPSSPTSCGGLASSSRRTPERRPICGGRSSPKVPASRSPSTRRPSGATPPPSGSMTSVRLKCPRGVNSSPGISRRSSSIRRSRFRVSDGRLWRRRRPSGS
>NC_016582.1|WP_148276897.1|666326_681947_-|lonely-Cys-domain-containing-protein
MDASKRKGRRVSTDPPDVALLFDAQAVVIGPSGRVVADALEPFAESSSVAHAVLDGAVRDEYGALGPEIEYRYPLDIGLLPDDVLRRLGIRIPEPPDEPDFMKVVLAQGPGVKIVVDKFFQWRHPNSPMPFDNASQAPPGSERVVIYIPEVVVDPAALVPGERWQSLEEARARRRLVRDRLARTGVAGRGGRPIPLRELLGDLPGWEITEVGQVTTVFPLAVGHNGRSYGQFSLGTAAVGRTMLWHHSIDRMWPRELRHLAWAGRDFGRRVAGELASRITGRGEVPVELVAFLSAIPDVDEAWGYAWRAFTHVAARPLNVTYPQLLKNWLTVASRHAFDSDRRALRPGTRGFLDERHDGLSAITHDMLKVEMERHFRLFKPGGGAVPEGFFDVEVRDPEVGDVPSAREHLTAALTGLTSQGRRIGTYESVGMDEFRALDTSGGRLLVALMVDEFRAYGFDHRWVTEEQIEQVEAELAELGRAMYERAVAASVPLSPDVLSRSVERILGDPVVRGFAPFLTLLDEGIPRADGPNLRILGELDGMTAADALGRHALGHVRLSADSPAYRLAAATVEKVSGLLAAGAVPAGERARVEEAVQGAREALRVLREGPAPAVIEWPAEIEALDGTGVPVDQVSQVQHRNASDVQVGVSLRGGGAGGSWLRRQGSYGLLPEVDHFTEVRWDLEEGNGYRASAVVAEGPRKEAPFRKVFLVGVDGDGTVARLPVQGGSIVSFVYERVVDYLFARVPALTAASWDTAVWWVGADVAGPYARGRDPLQWPVAGQVLSNRFDRWLWTSALGGEPGFATRREADGQGGQKQVTWLRLEEGDSLAGFRPEPSSVRLAVWAERVAGDRRRAGDVQRWWRAVRLVYGPLLEDDEAAFEALLRGFHALDQWRAGRGDASPLTWSGLLDVVNPYVEAVNAYVSETGRAPLVWWQVLPFTLVSAAGEVGVELELSRLDLTPRYVAERAWEQAPESSVAGRAGAALEAAEGSGGAAAPGVPGVSGADGAGARASVRALSVPSTSASGDSAARVFVAPVAPQTSEPPVLLAPQPTALPAPPAALAPQAPAPLAPQAAVLPPELPPLSVVEFAPDWTGPSGDGQRAIRALALKVVSAGMRNRKVGAALPRIVITGYGADVAGGGEWRARAAYAVFMGHLKQVLDILQVLSEGEERLAAEDFPFYVQWAPGEPSDEMVALSGVPREVLGRQATVGFALSPDAAAAERLEALHKRDRALRGDPFDVDVVARRVLHLPEGAPVDQSVRARLLGLVVEAEAAGRAGSLAALRAFHLERLGATGPAQSGYFTVDGHRVPGINWLGPDVMGDMDGLELDTDWSDVLTPQADGSLALGGGPGRQTPWPKGTRPYVVGADWRDGKVVVRLPDGSTVDVDVEEFIELVAADIARAGLPSGTPIVLAIPFLGRHSALLQKLADRTGLVVRAHSGEVKVSPRPDEKGDIGKVGIDTVTGRPGVPTGDWVPLRPGQGPVLDDSVPDWFHEVVMWPVVSEAIEEQVGYASFEPGEYAKDFEEPSRHADRITTFTHYHSALNAHALEQELPRPGPEGSPFPESDAYRITLHGLPGYVILTLWDGNDVVERFLGEGDAVAWVTWLVSRLPKERWLDISCCWIGSPKDSNSRGPALRGTFAPEVFVADPLRQVSLAQRIMNATRRWARVSYGPQGLGKVDGKYVRSLFVDPQGRLREFAPGRPEPEGAELDRLAVVAGLHSGVGAVPAAVRERTLIALRALKLMFGVHVEDRADFGDLLRGVAAVDSMWLADPDFRRAGPLMLDLLRQVIAARPEAASGVDQDVARRVLAAAATAWETRPRGPQGKRVELPLREFVDLPVVREAAEWLDGDEAKAEAVTVLKLSGRRPMVEAERSRMLWARVKTMELLSTTEMELDDLARQVLHMDPPFDVDESNLNKLRAALTHAFAVGRDAFDTDVAATFNLEVHGAFDDTATGMDTVLDGAKGSARDFTGEPRPQSRVNLAQVITSGGLVDAPWRNRNPNQQAAAKVPHLVRAELDPQDPDTILMAIGGRDFRGPISEFLEMVARDPTLIAKERGTEVVFSHAGLGTAADEVAWMLAQRLGCPVWWIDAPTNLSGKDGQGNPVLTVAAGAASGAVWQKAAVEPPPRVQHAPLPVPRPLPLPLGAPPGPPAPTTAPPATTTATTTATTTTTVPYAAPAVADAEGMAALHGGPALAPAPAHRVLSRRKLTDLVDGMVAVSVPSGGVSERRCLELLGALRDELHPGVLLASGVRAGGVVDESVLDRPGAASRLVVGPGWGRVGSWGAVEEALEKARLAGPGSVALVLARRPGSVSLERGRRPEDGLGHAFAAYHTADGGVVWVDASEPKGSRVSTRRPKMVPFDARAVVVGPSGRVMADALEPFAESSSVAHAVLDGAVRDEYGALGPEVEYRYPLTISVTPDLLRRLGIPERPGERPDLRKEVLAHGPGIRVTVDATEFWLDRATDRLFDPTAQQPPGARFEGVVHFIPEVDTDPAAVIPGERRQSWAAAEAKRKLVRDRLARTGTAERGGRPIPLVELLGDLPGWEITEIGQATTVHPLALDYDGRPYAQFSLGPPAVGRMMLWDHAINRLWRKDTLPLFVAGRRFGGQAAQELVGRLGYRDPAVADLLPFLAAIPDVNEVWGYAWMAFNQVATGPVNAAFTDTSDLLKNRLAVVSRSALDSVRRALRPDSRDFLDKRHDHLSVIAHAALTKEIERTFARYRPGEAVPYGFFDADEVPPPREHLTAALTGLTSQGRRIGQYESVGMNELPGLDTGNGTLAVPVAVDELRGYGFDGRTMTEEEIERAGAELVELGRQMYEEAVAARVPLSPEVLIRSLERIVNHPVVRGSLPLMWLAANGVPRVDGPPRPLLTAAEGMTVAKALARYALGHIRLPADSPAYRLMATAVGRASALLGSGSVLAEVRARVEGAVRSAERVLTAVREGPPPDAIEWKAEIEALDGTRVPVDRVSHVQHLNASGVQVGVSLRGGVVAGPWLYRQGSYGLLPGVEYVTRVRRGPVPGGVAGTPAVVAEGPRKKAPFDRVFLVGMDGDGTAAELRVQDGSGVAVGYPRVVDYLFARAPELTAAPWDTAVLVAGADVAGPHAPGRDPLEWPVAGQVLANGTGFDRWVWASALGLEFGFASDVEEVVDEDGVVRQKRVVRLQLAEGDWLAGFRREPSSVQLAVWAERVTGDRQLAGDVARWWRAVRLVYGPLLEDDEPTSQEDDESVSEEDDETAFEALLRGFHALDQWRADQGDDSLLTWSGLRALIDEHFVSLGQPAPPLAQALPVLLAWAADEIRMDLELEGSDLTPRHVPVRAWEQAPESPAADRAGAAPEAAGGSGADGAGARAPSGPSTSVRGESGSRVFIGPVVPPTAAPPAPRTAAPSSELPTLSVVEFGPGETGPSPDGHLAIRTLAVTVATAGLRNRPAGAALPRTDIIGYGAGVADGGEWRAGALRAVFTWHLNQVLDILQQSLPEGAGRLAAEDFPFSVRWAPEGPSEEAVALAGVPHAVLERQATVGFTLSPDAAAAERLEALQRKDRGLRSRPFDADVVARQVLHRPEGAPVDQAVRAELLGLVRAAEEAGRAGSLAALGAFHLERLGVTGPDQSGYFTVGGHRVPGLNWLGPEVMGALDALELDMDFSDVLVPGPDGSLAIDGGPGRETPWPKEKVPYVVGADWRDGKSGKDGRLVVRLPDGSTRDVGIEEFVELVAADVARAGLPPGTPIVLAVPFLGRYGVLLQRLADRTGLVVWPHSGEVKVSPLPGGKGGIDLVVGRPGVPKGAWVPLRPGQGPVLDDSVPGWYHDVVLWPMVSEETGEQIGDASFEPAEYARDFEETDRHIDQMTTYVNDYFTLRAGGRELELPRPGPEGSPFPEADAYYISLHGVPGYMILAVWSGNGVRTRFVGEDQAVAWVKWLVSRLPRDRWLDIPCCWIASPKDSNRTGPALRDVFAPGVFVANPLREISLTQRIVNATRFWARVSYGPQGKGRKNGKYMRSLTADARGRPREFALERPEPEGAELDRLARVARLHSGNGPVPDAVLERTLDALRALKSMFGIYAEDRADLGELLAGAAAVDSMWRADDDFKRAGPLTLDLLGRVIAERAGPGVGVDQDVVRRVLAEAATAWAAGESFGNFVVLPVVREAAGWLSGDGARSEAVDALKLSGPGQVREAERSRMFWARVKAGEVLDAPGMDETRRDALAVRVLHLDPDFDVDPRERERLWVVLTRAFAVGRDASDPDAAAAYDVEEYGAFDDTAMDTALDGAEGSGRDFTGESWSGVNLARIRQPAGLEDTPWRHQRPPQGRNQRATVPVPDLVRIELDERNPDIITLFIGSRVFRMPVGEFVELMANDPTLTDKRPGSTVVLSHARPAPGIGEVARRLTQLGRSVWWTETPTDLSGTDDQGAPVLTVLGASRAEWQKAEVEFPTPPVPPAPLPAPRPYPLPNSRPPGPGAPTMTPATTAVPTLSLAAPVVADAEGTVALQGGPATVPDLAPLEVAEGSGVEGAGSRALPEAPSGPLTSVPGGSGSPVFIVPVDPQSAEPPALHAPRAPASPAPLASEAVEVPIVLASETAEIPIALAPETAAASQSPDEAAAERLLEALHGRDRRFRSGPFDVDVLARHVLRLPKGVPVDQTVRAELFGLVRDAEADGRAGSLAELGAFRLERLGVTGSAKSGHFTLWGRRVPGLNWLGLDALELDTDWSEVLTPQSDGSLAPTGRPMRETPWPKGKWPYVVGADWREDKKKVVVRLPDGSTLDVDIEEFVELVAADVARAGLPPGTPIVVAVPFLGRHSALLQRLADRTGLVVWPHSGEAKVTPRGDGTGGIDTVAGRLGVPTGDWFPLRPGQGPVLDGSEPDWYPDVVMLPTVSEASGERIGVASFDPAEYAEDFEKPGRHSDQMTTYFDYHFVLGDLGPELELPRPGPEGSPFPEADAYRITLHGVPGYMVLTVWSGSGVVERFIDEGEAVAWVTWLMSRLPKDRWLDISCCWIGSPKDSNRPGHAPRGYFAPEVFVADPLRVVSVGQRIVNGARCWARVSYGPQGFGKENGKYVRALFADPQGRTREWDLLRLEPEDAELERLARVAELHSGPSAVPAEVLERTLIALRALKSMFGVHAQDRADFGELLRGVAAVDSMWLADDDFKQAGPLMLDLLRQVIVAHAGPGVMVDQDVVRRVLAAAATAGLIRCGWPTTTSSRRVR
>NC_016582.1|WP_014173165.1|664014_666369_-|hypothetical-protein
MWLADDDFKQAGPLMLDLLRQVIVGHAGPGVMGDQDVVRRVLAAAATAGKAGVPFRDFVDLPVVRLAAGWLNGGGAQSEAVDALKPSGPDQQLGEVERSRMFWAWVKTMDLLSAPGMDMDKVDKLAVRVLHLDPDHDVEPHHRERLRVRLTQAFAVGRGASDPDVAAAYALEEEYGAFTGTGLDTVQDGARGSGLDFTGQPRSGTVNLAQILAPGGLKNAPWRHQGPNQQATEPAPYLVRIELDELDPDSILLVIGDAVLQMPVREFLELMANDLTLTGKEEGTLIVLSHAWPAPGIGEVARRLAQRLGREVGWTDTPTDLSGKDDQNRSVLTVLAASDAVWRKAEVEAPQPPVPNAPRPIPRPYPRSGPPGPAAPTAAPPTTATTTRPTALGSAAPSGLAAASSATPPGEKPEDPASFLDDGVPSEPEESEESALSGAPPASPWDMARIRYAEEALDYEERLVTYLAADERINAEFARVVEAFWALVLHNGMDYRKFGSELPSENGAVGTSFESLQRVVESGNLRERADFLFAGAANGLLPDLTGGRVRRHPVVMGERDDRRKTEAYTRYKQRTEELRALGIDDAVIAEEVEDLMAVVRTPLRPEDVRPPLSQDERLIAVRASDGKLLWMPAGLSEELPMSAGLQQRSQESGGLVLTGTSGSTHFILTLVARLSNLANFPVDLGLIRAGLVSTMAYVGDHSFHEVMAGAQLVLDEVAHPGVPDYVDGRYRYRNVYPLTEEELRAHVARDGLFPDEHAMALFAELDDGAEEGSESDDGDDSSDR
>NC_016582.1|WP_014173164.1|663229_663964_-|type-VII-secretion-system-associated-protein
MSESNGEATTPATSGEAPATSGETPATVDPAPPEEFVQAAKAAPNHWLYLTDPTWRGEAPPPEFAVVGQWRSDDNGEIVEWQANEDYVPSPGARGWPEPTDDVDRAVQLATTGYGPADDVTAALAKAELAMLVTADGRPVSASAADGTAVVPIYTSARHLHKTGPLGFERVRIADVLDRIPEGHNVCVNSSAAVSMVLITDKLVQALAAVESAPAEEADGSERAEADQAEAGQADAREERGGQA
>NC_016582.1|WP_014173163.1|660032_663233_-|hypothetical-protein
MSRSGGARARWFSRRGARARTGPAADPAPSAPVTTLDRSERPGGGGRGRGGALLVEEYGGVMLLRSPADDTLSTSDVADLARALSVDPEHTVTVVAGADASSAGELWPRLGRVLDSLRSDGVGVVRLVLAAAGDDRPDEPAVARRIADAWEIEVIAPDGVAVVVPGGSLFVPERRSGRGVARGGGERGGWWRFAPGVEPVRIGSRQPAPAWQPAVEYLPVGTSGGYAVEQIPAGVLVRSRDAIPPRPDDLCYAVPADPRGPTVLLGAPHDEDIPAGDLTELLTALPEAVRPRVRLAPGGPRDILRTSQSVADSLGVELLVRTGMPLMSYGIPTEPGTVRSVLVGADGAPRWQPFVDTVVCAPAREGETAPSPRLSRWSPPVPGRGSAEHGAIRLSEQWRVTVTRAGLWITDTESEPPPATARAVDPEGPAIELGHPGRPIDATLYPVLGKLLGGLGADVCGRARLFVLGTCADGGRELRRIAAEHGLRTLRFGAGLAPARPEVRRPAPAESAEAPTEPGPAPVASAPAAEAEPEPDHERDPMSLGTLPEATPQEARLPEATPLETTEDPRPVFPPTRPSMVSTASAPVAAPAAHDTSAAPGEPAVSATSGAGAGPGPESSRPRTGGPGPSRPPGSGRVRDPERPEPPGADRPLRTGSGTPPPPMEPDQRSQSLPPMGLDAMLDLLRSQSPPDGAGDGDSAPSVSPLTRRPTQQGAPLSRPSQGQAPQATPNTPATPATRTPPASPESSEPPALAEPPAAPVSPAAPLSTTGSQSTQAPPPTTAPEPTTPVTPATPEPPAPEPPAAPLRPLPPVPFLPGHVSTEAERTAFRALADAVWERHSAAVTRALTRMPALRGPEQEAARIDLIALHMYLDTSYDLDTPDAPDTPAAGLSQDALARGMRTGDERLLPYAACVASALRRLPSYRGLACRRTHEADGGLVPGTLLRDPAPVCALPPGAGAPRPAGAQYAIWSVTGRRTRQLTGRPGSASGGDEVVFAPGTLLRVLDVRDTAGAPLVLLREVPTTASSPSAAGAVPQDTRLDDHDRAALDRLDEALRRHRPAATHG
>NC_016582.1|WP_148276896.1|658664_660011_-|RICIN-domain-containing-protein
MMPSQEPTNPKGPAVRRAVTLPGTAGTPDPSALAPLGAERTERTETGAAGATGAAVEADTAEQPKASLNEPASAGESVESVTPGAESVESATPGAAGAATASAGATAASEAGAPDTPAAPDVPPAEADGHADGHGSADGMASAEGDYPPGADTGADEDEPPSGRPTKALLAAAAIAGALLITVPFLAFGADDDDHKTEAAPEPTSGMTVPKIEEKGPGTYTAQSPAPSPTKESKSPSPAAKPRPEPSSEQPKSRPEPEPEPSSEQPKPRAKKVVPASKPYLLAPEQRTNFQLKNVTTGRCADLPGMGKGKLDGAVLQHDCFADWNADNQVWDFVLAQKGKGPNGRNLVVIKNKKSGLCLDLPQRGSQPSRTALNQTHCNLTLQDNQLWWVENRGGNRTFWIHNYASDQRCLEVWGEKPDFGGNDARLGIYKCSPTDDHEWRLMSKGES
>NC_016582.1|WP_014173160.1|657631_658252_-|threonylcarbamoyl-AMP-synthase
MAKYFDVHPENPQQRTIGNVADRIRSGALVAYPTDSCFALGCLMGNREGINRIRSIRNLDDRHHFTLVCQNFAQLGQFVHIDKDVFRAIKAATPGSYTFILPATKEVPRQLPHPKKKTVGVRIPDHVVAQALLADLGEPLLSSTLLLPGEDEPMTQGWEIKDRLDHVVDAVVDSGDCGTEPTTVIDFSSGEAEIVRRGAGDTARFE
>NC_016582.1|WP_014173173.1|727700_728189_-|type-VII-secretion-system-associated-protein
MAKSIQLNKEWMEHFINVDVHDFQVELKNILKDRGDIPALGSLKKENPHDFADPPIPSGTQLPLTIGAMTGDGEELTNGAHLHKTLVALIDQIVGMIEEQQTLFDDIEENLRETVHTLLKTQDGNLAKIDGEKFLDGLEDVEDDLTSGGSGSGGGDGENDEN
>NC_016582.1|WP_014173174.1|728298_728616_-|WXG100-family-type-VII-secretion-target
MDFSDGHIYVDFKGTDNAAEDMRLQTQNIDKILSQLESELQKFISSWEGEDRDVYVQKQKTWHEAVQEMKRLLASHAGLLNDIGDNYRTNQRNLTASWENVKIGR
>NC_016582.1|WP_014173175.1|728701_729037_-|hypothetical-protein
MSELTRSEESATRNGISSTEEAFANIQVCRQDVENTKANVGGAYGGSDGQKYQDLLQSWDDQAEIISKNLNDVIDTLNETLRANNLTQGSQKDAVDQEYAQSKAIFDALHG
>NC_016582.1|WP_014173176.1|729251_730703_-|type-VII-secretion-protein-EccB
MQTKRDQVQAHMFVMGRLTSAMLRADPDAPESPQGRTNRAVTISVLIGILLCAGAFVFGLLSPGTKSSWRDPGTLVINKETGTRYLYLGGRLRPVRNHTSARLLAGDQMKVMTIGSKSLRGTPHGSPVGISGAPDEPPGNDNLTGDPWQVCSGNTSGATGTTVAVGANADGAGLKSGQGLLVSGPDKEDYLVWQGRRLRLDQKANAAEALGYGSTKPVPVSAAFLNSLPAGPDLAPSAVPGRGGQGPELGGLKTRVGQVFKVAAPGGTARYYLLRKEGLAPLTATGAALVLGDPDTRQKAYAGGAVSPASLGADALSGHLAPDTPEVETGKRQPETPPEPVDLGAGRTPCVGVESGSDGTRVSVALIRDVNLGPTAQAPPEGLVPACVTVNRITVRPGGGALVHVLGAGGGEVGNTLYLVTDTGMKYRLPAADSLKALGYSEGEAQAIPSSLLAMLPTGPDLTPQAASMGRSKSSAPRCETNK
>NC_016582.1|WP_014173177.1|730735_732136_-|type-VII-secretion-integral-membrane-protein-EccD
MTDTQVADLCRLTVRAPAKSVDLAVPSDVPVADLLPAVLGYGGEDLGEDGVDHGGWVLQRLGGGPMDEERTLDSYDLRDGETLYLRPRTEALPEAHLDDLVAGISDTMRSRPYGWTPEASRRLLLGLAVTVLTAGLVVLALPGGSVGVRAVCAAVTGLLLVAGAGAASRAVGDAGAGATLGFMAAPYLAFAGWLLPGGDITGAHANEVVGSRLLASCVAGAGGAIVVLAAVAAYAALFLGTGVVAVFGAITGTLMITADLAPHHVAGIIALAAVVLGAFVPSLSFRMSGLKVPPLPTNAQQLQEGIEPHPTAAVAGRTALADGWMSSLYGAVGATCAACLGALAWYANLPSVLTVVVLSLLLMLHARGLGNTWQRLSLTLPGVAGLLLLILVGAESYAPDRRPLVAAGLLGLTAVIAIVSWTVPGRRLVPYWGRAAEILHYLMALSLLPLVLWALGVYSALRGLMA
>NC_016582.1|WP_106436514.1|732555_736476_+|type-VII-secretion-protein-EccCa
MPEGELNLQEPPTLPEEVPDSSAVWTYLPMALMSVSMMLMFMRPGMSRSSGSHFMYLAVGMMVLASGAMMLGQMMRKISERKQRLKGERRDYLRYLTQIRRKVRTAVADQKKALAWRHPDPAALWALVGTTRLWERRPQDEDFGEVRVAVGEQKLGLRLTPKATTPVEDLEPLAAHALRSFIRAYSTVPDQPIAIYLRSWARVLFRGDEERIRSVARAVIAQLVTFHAPDDIWVALCVSDERRADWEWVKWLPHNLHPQESDGAGQARMCVSAFNELEDLLGAEFLERPAFDPDAAAGREEPFTVIVVDGGSVPGGHRLDGPGFRNAVVLDLSGALTWRPGRVTLRFEVSGQDFTLVRTDRERKEQPTRLGRPDRFGPLGVTALAKRIAPYRMGMGSEVAEPLAANVELTTLLGISDLRRHDPATLWQRNTGSARLRVPIAVCADGTPLELDIKESAQGGTGPHGMLIGATGSGKSELLRTLVLALALSNSSETLNFVLVDFKGGATFLGLDELPHTSAVITNLAGEAALVSRMQDAVHGELMRRQELLRAAGNYTSALDYEKARASGTPLTPLPSLFIVVDEFSELLAAHREFMDLFVMIGRLGRSLGVHLLLASQRLDEGRMHQLESHLSYRIGLRTFSAMESRGVLGVPDAYQLPPRPGSGYLKSGVEALMRFRAAYVSGPYQERRAGANQARVASQTMPWTSGYVVPRQLSDLPEPEPEEELEETGDTLLSVAVERLLTAGPPAHQLWLPPLDLPATLDQVLPPLTPDPDLGLTTVGWPGRGRLTVPIGIVDKPFEQLRDLLTIDLSGVGGHVAIAGGPQSGKSTLVRTILTALALTHSPREVSFFCLDFGGGALAGLAELPHTAGVAARLDTERVGRTIAEVNSLLAARERYFLDHGIDSMATYRRRRAAGEFADQPYGDVFLVIDGWSTVRQDFDQHMQTFNSMAARGLNYGIHLIVTTARWVELSAGVRDQAGTHLELRMGDSMDSEINSRRAATVPRLPGRGLTRDGMLHYLSALPRIDGMESSEDLADGVAGLVAAVKESWPGPRTPQVRMLPTKLPVSQLPPPEGDLRMPIGLEESELSTVWHDFSETPHMIVVGDTESGKTNMLRLTAKAIMERYTPAEARIMVVDYRRTLVEAIPDEYRLGHAVSVDALRDMIGGAAPAVKERVPGPDIAPGRMKLCDWWTGPRLFILVDDYDMVGGDSMNAPFEPLLAHLALGYEVGLHLVVARSAAGASRGLNDRLLRRMLEVNTPGLLLSCPPAEGYLFGNIKGRVLAAGRATRIARHKTTQVQTALVDEG
>NC_016582.1|WP_106436515.1|736601_736787_-|hypothetical-protein
MPLTAGSASAAPQYRYFSTYKSAVDCQTAGNTLAQQGRITQFNCNGKIVQGREKVWDLFVR
>NC_016582.1|WP_078610286.1|737240_738497_-|S8-family-serine-peptidase
MRAMRRALSHRHPVARVVAAAALATAPLATAATPAAADPGSVELPAVASVLASDDPCAKASTRKAEDATWSRSTLGLGRAWELSQGAGVTVAVVDSGVGTDIPALSGRVTAVGDAGEDCVGHGSFAAGLIAAAPGEGVGVAGVAPGARILAVRGTRTRGETTAATLAAGIRTAADKGADVIYVGRALATGKAELTKAVAYAAEHDALVVAPVGPDFLPRDRNTGKAVEPAPWYWPASAPGVLSVIDYGPDGRRPDSAPALDGADLAAPGDAVVSVGPKGSGHYIGSGSSLAAAHVAGAAALVRARYPEMSAAEAARQLTVAAYPSETPRVDPYAAVSSLLTDKQGATPKPAAAHVPPAASPEPRHRALIIAGAGGGLLLLVAAGAVVIPRGRARRWRPGGARDREPAVTTEPAETGSS
>NC_016582.1|WP_043486024.1|738640_741958_+|right-handed-parallel-beta-helix-repeat-containing-protein
MSRQLLTVGPDQTENFRTIGEALAKARTGAVIRVKPGRYRENLTVRTRLTIVADGDRGSVEICPPRGTAVVLVADAVMLTDLMLRGGSEDLPVVDAPRGQVAMDGCTVVGSGWTALLARENGSLAMRGCRVSNPEGAGIVDTAPTGSVIDDCLIEHLGTSAVVLSEQARTTVRGCRMRDAKGNGLLANGEAQGRVEDCDISGTEKPAVALEGRCATHVARTHVHDTSVGVYVTSAARPVLEEVTVSDTTGPGIVLAQGADPELLRCRTARTKGNGLAVTERSRGTFQDCAFDAAASSAIRVVDSSAPLLSDTTVRDCADATAAVLLSEGASAEFDRLEVVDAAGVAVSIRTGANPLLRNARLLAPGGHGVEVTEDGRGRLEDCTVERSAGAGIRAAGGGAPEITGTVLRSTAQAAVWVGTGGRATVRDCQIHAGTAAGLHVESGAELSAGRTQVTEAGAHGVLVADGGRATLDACQISGSVGDGIRVDSSEQVTLTDCAVRDNRGAGLKQTRATERLTVRGLNSSGNITPDAWGETAGDLAQEGKAAAGPGEKKPEGPLAELESLIGLADVKHQVRTLVNVNQLAQRRASLGMPVPQMSRHLVFSGAPGTGKTTVARLYGGILAELGVLRSGHLVEVSRADLVAQIIGGTAIKTTEAFNEALGGVLFIDEAYTLLSDSRGSGADFGKEAIDTVLKLMEDHRDEVVVIAAGYTDEMSSFLASNPGLASRFTRTIEFANYSVEELVTITESMCAAHRYELAPSTLDALDRHYERMPRDATFGNGRAARQVFEEMIDRQAFRLGSMANPAEADLSLLLPEDIADESAVAAGADGRSSEELLADLDAMIGLQAVKHEVTDLVNLLSATKRRQAAGLPTPKISHHLVFSGPPGTGKTTVARLYAELLLSLGVLATGQLVEVARADLVGRYVGHTAQLTKEVFERALGGVLFIDEAYTLTPEGAGSDFGREAVDTLLKLMEDHRDEVVVIVAGYTEEMARFLASNPGLASRFSRSVDFEHYSTDELVEIMSRHATASGYDCAPETVEALLQYVAGLPRDRSFGNARTARQILEAMMTRQARRIGPMAAPGLEDLRLLLPEDLPVDTRQPAG
>NC_016582.1|WP_106436516.1|742009_742675_-|TetR/AcrR-family-transcriptional-regulator
MATEKRPAGGMSERRRTRLRLEISREAARLFWKQGVAATSGDQIADAVGLSTRTIWRHFRSKEACAEPIVMQGVVTLMSVLHSWPKDSSLEDHLAGELVRLQYETRPVDLTDEMLAMKMIRLADTEPALRTAWLMACDQTEQQLRVIIGDRLGRPAGDLEVRLHAAATAAVVRVLDEQIGVAFLADAGAGATELTEVKAAAGRFAHAIRAATGGAVGDPIA

Crispr_ID: NC_016582_2

• CRISPR_ID: NC_016582_2
• CRISPR_location: 2880420-2880505
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_2

Consensus_repeat	Method
CCGCGCTCGTCGTAGGTGTAGCG	CRISPRCasFinder

spacers of NC_016582_2

>2.1|2880443|40|NC_016582|CRISPRCasFinder
GGTGGTGTGGCCGGCGGGGTCCGTGGTGGCGGTGCGGTTT

CRISPR arrays and Neighbor proteins around NC_016582_2

CRISPR arrays

The CRISPR arrays of NC_016582_2

>merge|NC_016582|2|2880420-2880505|CRISPRCasFinder
CCGCGCTCGTCGTAGGTGTAGCGGGTGGTGTGGCCGGCGGGGTCCGTGGTGGCGGTGCGGTTTCCGCGCTCGTCGTAGGTGTGGCG

>NC_016582|2|1|2880420-2880505|CRISPRCasFinder
CCGCGCTCGTCGTAGGTGTAGCG	GGTGGTGTGGCCGGCGGGGTCCGTGGTGGCGGTGCGGTTT
CCGCGCTCGTCGTAGGTGTGGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014174708.1|2868381_2870475_-|putative-D--3-hydroxybutyrate-oligomer-hydrolase-lipoprotein-transmembrane	unknown	unknown	gnl|CDD|313759
NC_016582.1|WP_043489464.1|2871967_2872906_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176131
NC_016582.1|WP_078610363.1|2884238_2885186_+|hypothetical-protein	unknown	unknown	gnl|CDD|350159
NC_016582.1|WP_014174720.1|2886859_2887024_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014174709.1|2870510_2871818_-|citrate-transporter	unknown	unknown	gnl|CDD|225407
NC_016582.1|WP_014174719.1|2886421_2886637_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014174717.1|2883650_2884196_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014174723.1|2889152_2890634_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_043489459.1|2864840_2867243_+|GH92-family-glycosyl-hydrolase	unknown	unknown	gnl|CDD|377950
NC_016582.1|WP_055414137.1|2873006_2874245_+|CoA-transferase	unknown	unknown	gnl|CDD|367110
NC_016582.1|WP_106436562.1|2874252_2875155_+|CoA-ester-lyase	unknown	unknown	gnl|CDD|225184
NC_016582.1|WP_043486349.1|2896234_2898046_-|hypothetical-protein	unknown	unknown	gnl|CDD|275091
NC_016582.1|WP_014174724.1|2890630_2891839_+|MoxR-family-ATPase	unknown	unknown	gnl|CDD|223786
NC_016582.1|WP_014174705.1|2863915_2864707_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187593
NC_016582.1|WP_014174707.1|2867289_2868357_+|zinc-dependent-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|176221
NC_016582.1|WP_014174716.1|2883039_2883528_-|glutathione-peroxidase	unknown	unknown	gnl|CDD|238207
NC_016582.1|WP_078610873.1|2875346_2876156_+|hypothetical-protein	unknown	unknown	gnl|CDD|238871
NC_016582.1|WP_078610364.1|2885208_2885451_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014174725.1|2891835_2896218_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|315987
NC_016582.1|WP_014174714.1|2876212_2878045_+|glycoside-hydrolase-family-9-protein	unknown	unknown	gnl|CDD|376383

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014174708.1|2868381_2870475_-|putative-D--3-hydroxybutyrate-oligomer-hydrolase-lipoprotein-transmembrane	gnl|CDD|313759	pfam10605, 3HBOH, 3HB-oligomer hydrolase (3HBOH). D-(-)-3-hydroxybutyrate oligomer hydrolase (also known as 3HB-oligomer hydrolase) functions in the degradation of poly-3-hydroxybutyrate (PHB). It catalyzes the hydrolysis of D(-)-3-hydroxybutyrate oligomers (3HB-oligomers) into 3HB-monomers.	0
NC_016582.1|WP_043489464.1|2871967_2872906_+|LysR-family-transcriptional-regulator	gnl|CDD|176131	cd08440, PBP2_LTTR_like_4, TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.66036e-62
NC_016582.1|WP_078610363.1|2884238_2885186_+|hypothetical-protein	gnl|CDD|350159	cd09008, MTAN, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases. This subfamily includes both bacterial and plant 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidases (MTANs): bacterial MTANs show comparable efficiency in hydrolyzing MTA and SAH, while plant enzymes are highly specific for MTA and are unable to metabolize SAH or show significantly reduced activity towards SAH. MTAN is involved in methionine and S-adenosyl-methionine recycling, polyamine biosynthesis, and bacterial quorum sensing. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	1.2839e-14
NC_016582.1|WP_014174709.1|2870510_2871818_-|citrate-transporter	gnl|CDD|225407	COG2851, CitM, H+/citrate symporter [Energy production and conversion].	4.63493e-148
NC_016582.1|WP_043489459.1|2864840_2867243_+|GH92-family-glycosyl-hydrolase	gnl|CDD|377950	pfam07971, Glyco_hydro_92, Glycosyl hydrolase family 92. Members of this family are alpha-1,2-mannosidases, enzymes which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis. They are critical for the maturation of N-linked oligosaccharides and ER-associated degradation.	0
NC_016582.1|WP_055414137.1|2873006_2874245_+|CoA-transferase	gnl|CDD|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.22629e-112
NC_016582.1|WP_106436562.1|2874252_2875155_+|CoA-ester-lyase	gnl|CDD|225184	COG2301, CitE, Citrate lyase beta subunit [Carbohydrate transport and metabolism].	2.82439e-55
NC_016582.1|WP_043486349.1|2896234_2898046_-|hypothetical-protein	gnl|CDD|275091	TIGR04267, hypothetical_protein, HEXXH motif domain. Some proteins with this domain toward the C-terminus have an N-terminal region with a radical SAM domain (pfam04055) and a SPASM domain (TIGR04085), a combination frequently associated with peptide modification. All seed alignment members, and all family members that are not fused to a radical SAM domain, have a motif HEXXH that suggests metalloprotease activity. A role in peptide or protein maturation is suggested.	2.0797e-106
NC_016582.1|WP_014174724.1|2890630_2891839_+|MoxR-family-ATPase	gnl|CDD|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.96799e-19
NC_016582.1|WP_014174705.1|2863915_2864707_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187593	cd05332, 11beta-HSD1_like_SDR_c, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs. Human 11beta_HSD1 catalyzes the NADP(H)-dependent interconversion of cortisone and cortisol. This subgroup also includes human dehydrogenase/reductase SDR family member 7C (DHRS7C) and DHRS7B. These proteins have the GxxxGxG nucleotide binding motif and S-Y-K catalytic triad characteristic of the SDRs, but have an atypical C-terminal domain that contributes to homodimerization contacts. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	7.23924e-55
NC_016582.1|WP_014174707.1|2867289_2868357_+|zinc-dependent-alcohol-dehydrogenase-family-protein	gnl|CDD|176221	cd08260, Zn_ADH6, Alcohol dehydrogenases of the MDR family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. This group has the characteristic catalytic and structural zinc sites of the zinc-dependent alcohol dehydrogenases. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
NC_016582.1|WP_014174716.1|2883039_2883528_-|glutathione-peroxidase	gnl|CDD|238207	cd00340, GSH_Peroxidase, Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per subunit, which is involved in catalysis. Different isoenzymes are known in mammals,which are involved in protection against reactive oxygen species, redox regulation of many metabolic processes, peroxinitrite scavenging, and modulation of inflammatory processes.	6.02872e-88
NC_016582.1|WP_078610873.1|2875346_2876156_+|hypothetical-protein	gnl|CDD|238871	cd01833, XynB_like, SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.3985e-56
NC_016582.1|WP_014174725.1|2891835_2896218_+|tetratricopeptide-repeat-protein	gnl|CDD|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	4.51415e-11
NC_016582.1|WP_014174714.1|2876212_2878045_+|glycoside-hydrolase-family-9-protein	gnl|CDD|376383	pfam00759, Glyco_hydro_9, Glycosyl hydrolase family 9.	8.06952e-55

Protein sequences

>NC_016582.1|WP_014174714.1|2876212_2878045_+|glycoside-hydrolase-family-9-protein
MPARLPRPRGARGAAALLAAALLLIAAPAAPATPANSAAAAAAAAPSAVQVNQLGYLPSGPKRATVVTTATTALPWQLRNATGAVAASGTTTVHGADTASGDTTHLVDFSSYQGTGTGYTLTVDGRTSHPFDIRADLYDGLRSDALSFFYQQRSGIPIQASLAGAAYARPAGHLGIAPNKGDTSVPCQTGVCDYSRDVRGGWYDAGDQGKYVVNGGIAVWQTVNSFERAKRSGHQAALGDATLRVPERGNRVPDVLDEARWELEFLMRMQIPEGKPRAGMAFHKIHDAQWTGLPTRPEQDSQPRELHAPSTAATLNLAAVAAQCARVFAPYDKAFAARCLASARRAWSAAKADPNVLAPDSDGTGGGAYGDTRVDDEFYWAAAELYATTGESAYRDAVTSSPFHTSADAFTPLGFAWPDTAALGRITLATVPNGLPADDRARIRASVVSAADGYLDAMARQGYAVPLPEDGYVWGSNGQVANNASVIAVAYELTGHRRYRDGALETLDYLLGRNALGQSYVSGYGEQASHNQHHRFWAHQADASLPNPPAGALAGGPDSALQDPVAQEKLPGCAAAKCYIDDIGSYSTNEVAINWNAPLAWLAAFAAERG
>NC_016582.1|WP_078610873.1|2875346_2876156_+|hypothetical-protein
MRPVGPAPDTATATPGTAAAAPDTAITPAAATDTAAAPVRIMPLGDSITGSPGCWRAVLWNKLQSTGYTSVDFVGTLGPQGCGVPYDGDNEGHGGFLATAVAQQNQLPGWLSATHPDIVVMHFGTNDVWSNIAPDRILAAYSTLVDQMRQSNPNMKVLVAQILPMNPGSCPECAARVTALNARIPGWAAAKSTSRSPVIAVDQWSGFSTATDTYDGVHPNASGDDKIAARWYPALTKLLTPGLTDRAAGALRADDASVAATAEEATVHR
>NC_016582.1|WP_106436562.1|2874252_2875155_+|CoA-ester-lyase
MQHGRDRELLRSLLFVPGSRTGWLPKAEAAGADAAILDLEDAVPQGAKEAARKAVAEAVARAARTPGPMRLLVRINPLDHGAGWAGAEDLRAVARPGLYGVVLPKVRCADDVRVADRLLAWCEREAGLPEGRIALVPLLETARGLREAYDIGRAAGRVAHLGALTAPGGDVERAVGYRWSPGGEETHPLRARVLLDARAAGSPHPVAGLWADVADLVGLRRFAEQNRALGYEGMTVIHPSHVAVVNEVFSPDAEELARCERLVAAVAAAQARGEGAVLFEGRMVDEAMAETARRTLARRV
>NC_016582.1|WP_055414137.1|2873006_2874245_+|CoA-transferase
MDNDSRAAQGQQGRPGQQGQLTGLKVVEFAHVVAGPLAGAMLADQGADVVHVEPPGAGDAARAMGPRRDGVPLWFKVAGRNKRSVTLDLHHEEGRRIAHDLIAWADVVIVTLRAGRLRAWGLDWEAVHAVNPQAILLQISGFGATSSRADAPGFGKMGEARSGVVHLTGFPDGPPVHTGFSHGDAVTGLMGAFAILAALHRRDTDPDFDGEWIDLALFEPLFRLVEWQIIAYDQLGAAPERAGNQLAVAPAAVINTYRSGDGDWLTVTSATTRSVLNVVRLLGLDEEAYATVEAQHAGRERLDHALRAWVAARPADECLAAFERAEVVASRVFSAADIVTDPVYAEREDVVTVDDPDLGPVRMQAALPHFRRNPGAVWRTGPALGADNGLVYGQWLGIDGERLAKLEGQGVI
>NC_016582.1|WP_043489464.1|2871967_2872906_+|LysR-family-transcriptional-regulator
MDVTLRQLAAYAAVARAASFTAAAADMHVSQSSLSRAVADLERTLGMRLLERDTRNVQLTPAGAEALRIADQILSAHRAGLAQLGRYVSGERGTVALSTLPSVAAVLLPPVISAFRARRPEVTVRLLDGLERPVLERVVDGDADFAVSTVARRTAGIRLRPLVRDRFDAVLPEHHPLAEKPEVSWADLGREPFLAVGADSSVRRMTDAAFAQAGLSADPAAEASSVATVGGLVAAGLGVSAMPALVHPLVPPGKLVRRPLVEPVVERRLHVVLPARRALPPGARRFLEQLEEFRDAGHGLPDGVFWEDGEAR
>NC_016582.1|WP_014174709.1|2870510_2871818_-|citrate-transporter
MLAALGFCTIGGFLLLTMTKRVSVLVALVLTPVIAAVIGGYGDDLGPMALDGLSKVAPTGIMIAFAVLYFSLMVDAGLFEPLIRGILRIARRDPLRITVGTAALTICVALDGDGASTFLITISAMLPVYQRLGMSRLVLAGVVALGAGVMNMVPWGGPTARAAAALKLDTSDVITPLLPALAAGIAWVLLAAYLIGRRERRRLGELDAPPAETAVVGDGPGTPRVATRAGTALTVFNLLLTVTLLICLVLEVMPLPVLFVLAFVIALLVNHPGWEEQQALLEKHGNSVVLVTTMIFAAGVFTGILTGTGMIEKMAQAMVEVIPDSLGGHLPVLVAVTSMPLSLVFTPDAYYFGILPVLAGTADSFGTDPAEVARAAVLGQMTTGFPLSPLTAATFILLGMSGVQLGEHQRFIFRWAFGTTLVMTAAALLTGALPL
>NC_016582.1|WP_014174708.1|2868381_2870475_-|putative-D--3-hydroxybutyrate-oligomer-hydrolase-lipoprotein-transmembrane
MPKPLRLRRSAALAPLLAAALTAALAPPATAAPAAPRAGLPSYISALSSVRYDGADDDLLTAGLGFSGLRAAAPPAPADPDRPTAAELRRQAIWASAGLYAGSGGGLGRLYGPNVDRGRPVPGDGKVAGVEYRAVAGSGSHSVSFVVQVPDDFDRSRPCVVAAPASGLGGVYNMVGTAGAWGLHRRCAVAYTDKGMGPAFDDLHSGTVMAYDGTTGPRAQTADRAAFDAGLSDAERARFDAERPYRVAYKMAHAKTNPQATWGRDVLRSVELALALLDRDWRRGAPRAGYTPATTTVIATGVSNGGGAAVAAGEDDHGGLIDAVVASEPQMNLAPLNGIRVTQGGRAVPAAGLPLIRYGSLASLLQPCAALTEPTAPGYSSLDTAAAHRRCAALVGDDPRLISRRDAKRAGPDGLPRLAQEALVRAGYQPQSSYLQLAHYDPQTPASYAMSFARASVADSLCGYGWARTDASGTPVPYRTAELAAAFGTSSGRAPAPGVLIDENSPGGPVADAKSQGPDGRHDYNLRGESCVYRLAFNTAQEPEWAARLAEGLDATRRTGDLHGKPALIVHGRDDTRVPVNHSSRPYLGLNSRTQHGAGTVAYVEVTNAHHFDSTAPGYDNRYVPLGYYYQQALDVMWQRLTQRGQLPPSQVVRTVPRGGEPGHAPDLTPANVPDIADRPAAGDRVRITDGTVRIPG
>NC_016582.1|WP_014174707.1|2867289_2868357_+|zinc-dependent-alcohol-dehydrogenase-family-protein
MRAVVFDAFGHRPEVRNVQDPTPSRRGAVIRVEATGLCRSDWHGWMGHDPGIRLPHVPGHELAGVVEEVGPEVLNWRPGQRVTVPFVCACGRCGACADGAQQVCERQTQPGFTHWGSFAEYVAIENADVNLVGIRGELAFTTAAGLGCRFATAFRAVVAQGRVAPGEWVAVHGCGGVGLSAVMIASAAGARVVAVDISPRALALARRFGAEVCVDAASTLGSVADAVADATGGGAHVSLDALGSPRTCAASVNSLRRHGRHVQVGLLPPAAGSPMLPMDRVIALELRLLGSHGMAAHAYGPMMEMVEAGTLRPDLLVTDTIGLDEVPEALMAMGAAAGAGVTVIEPRRPATAARR
>NC_016582.1|WP_043489459.1|2864840_2867243_+|GH92-family-glycosyl-hydrolase
MPKLGRIRKRAARAVTPLTAAALLLGGLLGPPGAAAAPAAEPAALVNPFVGTQNFGNTFPGAGAPFGMVQVSPDTGGQGGYDYAQNTIYGFSQTHLSGVGCGVAGELPLMPTTGPVTDVDPEHYRSAYSHDDEEATPGYYRVGLSRYGVDAELTATERTGWQRYTFPATGAANVLFNTGKANQKVFDSEVRVVGDRTVEGRVRAGNFCAGKDEHTVYFTATFDRPFSSYGTWRGTTATPGSREAAGEGGNGAWAGFDATADRDVVVKVGLSYTGLDGARKNLAAETGDGYDFDATRAKLRDTWERQLDSVRIGGGTPERRSAFYTALYHAQLHPNLAGDVDGRYTGFDGRTHTATDYTPYQNFSLWDTYRPQNQLLELLQPRVARDVALSVVGIGRDGGWLPRWALAESETNIMTGDPVTPFLVEAWSKGLLAGHEEEAYGLLKRNATSTPPADSPYNGRSGVDHYRRLGYVPSGLELGKDCAHKGGDNDCVHPASATLEYSAADASLALMARGLGHRADAKMFAERGQWYRKLWDASIAQFRPRTADGAWVTPYDPVEAGRQFHEGGAYQYQWLVPQDPAGLVGLMGGRRATEQRLDSFFAYDKLLTDPAGTARRDWISAPYDYYGKPTYNPNNEPDLHAPYMYLWAGAPAKTATVVRAAMTLFTTGPDGMTGNDDLGTMSAWYVFSSLGLYPTMSGGDFLAVSSPQFESAVVRIGRYGTRQGGTLTVTAPGASDERRYVRDVSLNGRDLPRTWLPWSSVAHGCSLAHRLGTEPSAWGTRPGAEPPSVGGAGRPGSNVV
>NC_016582.1|WP_014174705.1|2863915_2864707_+|SDR-family-NAD(P)-dependent-oxidoreductase
MRIGGATVLLTGATGGIGQSLARALAARGAKLLLTGRREEVLQPLADRLGARAIVADLADRAQVDDLIAEAAGADILIANAALPSSGEVLGYAPDEVDRALEVNLRAPLQLARALAPRMVASGSGHIVMIGSLSGRTASPSAALYNATKFGLRGFALGLRQDLHGTGVGVSVVQPGFVRDTGMFADSGATTPPGVRTVSVRQVAVATLRAIERDRAEVNIAPLELRLGSALGGLFPSLAAVAQRNAGADRTTRQLAEGQRHNR
>NC_016582.1|WP_014174716.1|2883039_2883528_-|glutathione-peroxidase
MSLYDIPLHTLSGEPTTLGAHQDAALLLVNVASKCGLTPQYEGLERLQQRYAERGFTVLGFPCNQFAGQEPGSSEEIRSFCSTTYGVSFPLMEKIEVNGEGRHPLYAELTKTADEAGEAGDVQWNFEKFLVSPRGEVVARFRPRTEPEAAEVVAAIEAQLPR
>NC_016582.1|WP_014174717.1|2883650_2884196_+|hypothetical-protein
MSRDEETVVGRLLIVEYEQVKEEQRARIGFRDNLLYATLASMAAIITFSLQGGGRPELLLLLPPASVLLGWTYLVNDEKISAIGRYIRQDLDPRLATLAPDRTRVFGWETAHRDDRRRISRKRLQLAADLLLFAVAPIAALIVYWTNGPAKAPLVAISVAETLLIAVLTVQIVLYADLHRP
>NC_016582.1|WP_078610363.1|2884238_2885186_+|hypothetical-protein
MWSDGDGGPAGGARAEAVILTALEVEYRAVRAHLEELRTVAAERGSLFEVGVFREGHHPGTSVAIHMTGPGNPGAAALVERASALFAPRTLLFVGVAGGRKDVGLGDVVAAEAVYDYETGKDTEDAFLPRQKTHQPTYDLVQLARMIAAGDEWQRGIRPAGGGAAPRPRAHVKPIAAGGRVVAHQRSEVGAHRGGRPGGGPPALGGRPPAHGGRGRRGGGGHGGLRLPGGRVRQPAGRRPGDPRHLRSARRQGRGTRRALAARSLPARGGVRLRTPPPAARARGEADPRDCPGRPRGNDLRHGLPHRCCPQTEDP
>NC_016582.1|WP_078610364.1|2885208_2885451_+|hypothetical-protein
MLAVPGLTSPTAWQQLLDELPGVGTQVARQSASRTEALALLRTCEAYGAWDALADVLTVIAPDAPATAELIARLKLLGLG
>NC_016582.1|WP_014174719.1|2886421_2886637_+|hypothetical-protein
MAPDPTTPHRDDRNHDIRVYLLLLALAMILIVVTALAYVTYRHPALTGPLGVGCAAAAVLVTGLGFAVTRR
>NC_016582.1|WP_014174720.1|2886859_2887024_+|hypothetical-protein
MARQSASRAEALPLLRTCEAYGAWTQLADVLAIIAPDAPATAELIAWLKLLGPS
>NC_016582.1|WP_014174723.1|2889152_2890634_+|hypothetical-protein
MAATGEGGLRLVQHLVTALKEFRCLMEPDSRELCLELVARELDEVLPVRNHRVTNYFLVELAKECLDNERFMWALRGSLAILAPDAPAMTRLDCVMEQMTARPALPTDATERLRSLLEGLEVAQLTRLCQGAAGPLQEVPPVTGAWHAFETLSRMNARPDGLPPNLALVEYLAASARPLELADRLRSWADEQARELSLKSPLRSLRQQVGHAAPAEAIDAYLVIQLLPQDEPGRYELSSWHAYDPTGWYPIRGPVSNVTAATAERAVQDLVREATAEWEDAHCIHLEFVLSAEDLHLPVHMWRHELDSDFPTPLCDTYPVVVRSLERSQNRHWYRPWKKRWQTFSSQPERSRHLVVDGPDPDSPPSGDPGALLARLNADEHVVALVLNAPPGASQEGSRQASAAWRAGIPVVVWDRRHPRDPDFAHHLRQKATGDLARVREAVKELRVESQGLASAEREQHLGQHVMLVWDDPTRPVETQGRLAGPDEGVGSR
>NC_016582.1|WP_014174724.1|2890630_2891839_+|MoxR-family-ATPase
MTDAGPTSRHNGHANGDPGSTSRVGPSSAGVPRPWWIYQGTGRPLHDVSLEEILPPPPPWRTFNGVSAGPPDGIEAVARESSNEVLQNREGEAPTEPPAPPEDEQDAARRLGAAPLGMRSEPEEADVVNAALILRRPLLVTGRPGTGKSTLAYRISRELGLGRVLRWPITTRTTLRQGLYDYDAVGRVHAAAAGQAADAELHEPGPEDIGDFLQLGPLGTAMLPHRLPRVLLIDEFDKSDIDLPNDLLDIFEAGEYAIPELVRIRSRRPAVRVLTDDPDRSTVIASGRVRCRAFPIVVITSNDEREFPPAFLRRCLQLRLPDPDADRLAAIVAAHLGRADDPRALDLVQMFLERSRLEGGLAADQLLNAVYLVTSQAQVPGPEWEELLHAVWHRLDAAGPKP
>NC_016582.1|WP_014174725.1|2891835_2896218_+|tetratricopeptide-repeat-protein
MTHDPADGSSERGRPDLDWQQIADALWLAVCKAETDREAARPTPAPPSPSPTADQPPRTPDPPQDSPTDAEHEAPRPEGDLVLTAPSPVELVGVPAPADETPVQAIAADVVTPAPRLAAVSPPTAERALSRALRPFKRTSPSPVEDEIDEDATAERAAREGLWLPQCVPVRERWMDMVLVVDSSSSMVVWRQTVGQLVTVLERTGAFRMVRVHRINSDHPLPADPAGRRNAADRARSGRSPVDGIPPRGRRAVLVLTDGIGTAWADDTGKQALGRWARHATVAVLHVLNQGHWHHTGLVPERVRVRVLEPGAPKRTWQRTDGAPWPGGEPPVPMLELEARWLHRWAQLVTQPSTRGRDTLALLPGVPAERWEREPEPTARDRVFRFRASASPSAFRLASRLAAAPLNIPVMEFVQGMHEPQGSPGDLAEILLGGLLRKVGAADPLDETGIGYEFHQGVRELLLSAGMRDESLYILRSVLDRLGRRWKPLHVLRDALNHPSGTLPELPETERLLPYMRVQEKVYQALSGPYLEGARTFHARAALAQQALGRSGERGAGPVEDPPNGGSAVSNTKMSRSKPTSPKEESSPPQAHGTPGAAGEHPRGSFVPVTAARSLPALEERRAGDPPAIWGNVPPRNNNFTGRQALLDTLHERLSSEGTAAVLPEALHGLGGVGKSQIALEYVHQHAADYDAVWWIPAERPEQIRQALVQLADRLGLQVGLESNIAVPSVLEALRTGRPCRDWLLVFDNAEELDTVRPFFPNGGPGRILVTSRNAQWSRAARTVEVDVFDRQESVELLRRRGPELPDEQADRVAEALGDLPLAIEQAAAWLTETGMPVDEYLHVFEDERADVSTRRAELLAQGVPVDYPEPVAAAWNMSLRRLAEHHAGALQLLQVCSFFAPEPISRRLFSGVRGVSLSPELSEVLQDPIKLGHAIREINRYALIKINHRNNTIEMHRLVQAVLMGQMSPQQQADMRHSAHVLLAYGDPNDVAPVNWPRYADLLSHVRASRAMECDDKWVRQMARNLISFLFVWGDHQGAREFGSQVVETWRQTLGEDSLETLSASRTLGHALTALGHYEEARELNDRILELLRAHPQAGENNEDTIATMGAVANSARLQGDYGRSVELEKDRWTRALRVFGEEDPYTLAAANDYGLALRAVGDFALAQEIHQPARDTAAIVLGEDSLTTILLSTHLSSDARGIGQYHAARAMQEETFALALRSVPPNAPTFVAAMRTLAVARRKAGDHEGAIELTRQALDSYRLRYIEPNLDITTAEMNLSMDLRQNADLAGARDLGRKSLEDLRVILGPRHPYTSSAATNLAVTLRLLGETEEALALNRETLPVFVETLGADHPSTLTCAINLASDLYTLADYEEAHSLDTDSLAACRERLGEDHPTTLACAVNLSADLRALGESRSAEELHNDALERFRRVLSAQHPATIAAARGIRADCDLEAYTF
>NC_016582.1|WP_043486349.1|2896234_2898046_-|hypothetical-protein
MSRHHRLSTACFEELAHGGGGASAIAELRAGQRSRLMLLLRALTDLASSHPRVPGPLPAPREAWELLIRAERRSPSSVARLLLHPQVGAWLSRCLRRLRGVAEEVSDELPLWLETGYLHTVAASAALLAEIDFRILVGVRDGGVILPALGLVDLAGCDSPVAEISADGAGERIARAAAHMVPLPSDLTRDVEGWHPLRRLHGRHPVHPCSPYLDDIDPYRDFLRPSAPTRLSEPEARGWQEHFDSAWALVARQSNVDPAGVADCLISVVPVRYPARTEPFSASSPEAYGCVLLNPPTDSATLAASLIHEAQHVKLSALLDLVPLMHGGMEEIHYAPWRVDPRPLRGLLHGVYAFLGVTAFWQAHRHVAADGTTRAVAEFEFALRRAQTSHGLRTLRAHAELTALGDRFLRGVEGRLAAWLTEPVPESPLRAAEDLNLDHQLLYRLHHLSVDPGRLGEWVRAWRLGRPAPDVLPATALRTSRTAVSARPALIRLSLRDPAGFALLREKPEERPFDGADAPLRADLDWAAGDTAAALRGYRDRLAERPDDLPAWSGLALTLPAGPAKEALLDYPEAVLAVHRALRAPVYGGPDAVALAQWIGSRR

Crispr_ID: NC_016582_3

• CRISPR_ID: NC_016582_3
• CRISPR_location: 3032972-3033062
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_3

Consensus_repeat	Method
ATCACCGACCCCCTCGGCGCGACCACC	CRISPRCasFinder

spacers of NC_016582_3

>3.1|3032999|36|NC_016582|CRISPRCasFinder
CGAACCCGGCAAGACCGTCGCGGCCGGATCCTGTCC

CRISPR arrays and Neighbor proteins around NC_016582_3

CRISPR arrays

The CRISPR arrays of NC_016582_3

>merge|NC_016582|3|3032972-3033062|CRISPRCasFinder
GTGACCAACCCGCTCGGCCACACCACCCGAACCCGGCAAGACCGTCGCGGCCGGATCCTGTCCCAAACCGACGCGCTCGGCCAGACCACCG

>NC_016582|3|2|3032972-3033062|CRISPRCasFinder
GTGACCAACCCGCTCGGCCACACCACC	CGAACCCGGCAAGACCGTCGCGGCCGGATCCTGTCC
CAAACCGACGCGCTCGGCCAGACCACCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014174828.1|3039528_3040575_-|lantibiotic-biosynthesis-protein	unknown	unknown	gnl|CDD|372883
NC_016582.1|WP_014174829.1|3040558_3043126_-|lantibiotic-dehydratase	unknown	unknown	gnl|CDD|377403
NC_016582.1|WP_014174821.1|3023805_3024621_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|236612
NC_016582.1|WP_043486373.1|3036142_3037741_-|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl|CDD|334815
NC_016582.1|WP_014174832.1|3046014_3047925_-|hypothetical-protein	unknown	unknown	gnl|CDD|163405
NC_016582.1|WP_014174818.1|3017320_3021547_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|274860
NC_016582.1|WP_014174825.1|3035669_3036092_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014174830.1|3043122_3044139_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014174820.1|3022023_3023712_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NC_016582.1|WP_014174814.1|3012304_3012559_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_043489503.1|3048326_3049514_+|YcaO-like-family-protein	unknown	unknown	gnl|CDD|224855
NC_016582.1|WP_014174833.1|3047994_3048147_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_043486376.1|3044135_3046028_-|TOMM-precursor-leader-peptide-binding-protein	unknown	unknown	gnl|CDD|274674
NC_016582.1|WP_043489494.1|3011909_3012191_-|DUF1876-domain-containing-protein	unknown	unknown	gnl|CDD|378103
NC_016582.1|WP_043486371.1|3024964_3025933_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|236612
NC_016582.1|WP_014174816.1|3013547_3015791_+|MMPL-family-transporter	unknown	unknown	gnl|CDD|225272
NC_016582.1|WP_014174823.1|3026150_3030866_+|RHS-repeat-protein	unknown	unknown	gnl|CDD|225750
NC_016582.1|WP_014174819.1|3021689_3021980_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014174817.1|3015902_3017150_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NC_016582.1|WP_014174827.1|3038050_3039532_-|SagB-family-peptide-dehydrogenase	unknown	unknown	gnl|CDD|188352

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014174829.1|3040558_3043126_-|lantibiotic-dehydratase	gnl|CDD|377403	pfam04738, Lant_dehydr_N, Lantibiotic dehydratase, C-terminus. Lantibiotics are ribosomally synthesized antimicrobial agents derived from ribosomally synthesized peptides. They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues. This family constitutes the N-terminus of the enzyme proposed to catalyze the dehydration step, via glutamylation of the substrate during lantibiotic biosynthesis. The enzyme dehydrates Ser/Thr residues in the precursor by glutamylation.	1.96396e-25
NC_016582.1|WP_014174821.1|3023805_3024621_-|helix-turn-helix-domain-containing-protein	gnl|CDD|236612	PRK09685, PRK09685, DNA-binding transcriptional activator FeaR; Provisional.	2.8043e-25
NC_016582.1|WP_043486373.1|3036142_3037741_-|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl|CDD|334815	pfam02113, Peptidase_S13, D-Ala-D-Ala carboxypeptidase 3 (S13) family.	1.4439e-125
NC_016582.1|WP_014174832.1|3046014_3047925_-|hypothetical-protein	gnl|CDD|163405	TIGR03693, ocin_ThiF_like, putative thiazole-containing bacteriocin maturation protein. Members of this protein family are found in a three-gene operon in Bacillus anthracis and related Bacillus species, where the other two genes are clearly identified with maturation of a putative thiazole-containing bacteriocin precursor. While there is no detectable pairwise sequence similarity between members of this family and the proposed cyclodehydratases such as SagC of Streptococcus pyogenes (see family TIGR03603), both families show similarity through PSI-BLAST to ThiF, a protein involved in biosynthesis of the thiazole moiety for thiamine biosynthesis. This family, therefore, may contribute to cyclodehydratase function in heterocycle-containing bacteriocin biosyntheses. In Bacillus licheniformis ATCC 14580, the bacteriocin precursor gene is adjacent to the gene for this protein. [Cellular processes, Toxin production and resistance].	1.04681e-16
NC_016582.1|WP_014174818.1|3017320_3021547_+|FHA-domain-containing-protein	gnl|CDD|274860	TIGR03928, T7_EssCb_Firm, type VII secretion protein EssC, C-terminal domain. This model describes the C-terminal domain, or longer subunit, of the Firmicutes type VII secretion protein EssC. This protein (homologous to EccC in Actinobacteria) and the WXG100 target proteins are the only homologous parts of type VII secretion between Firmicutes and Actinobacteria. [Protein fate, Protein and peptide secretion and trafficking].	1.85321e-139
NC_016582.1|WP_014174820.1|3022023_3023712_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.7819e-76
NC_016582.1|WP_014174828.1|3039528_3040575_-|lantibiotic-biosynthesis-protein	gnl|CDD|372883	pfam14028, Lant_dehydr_C, Lantibiotic biosynthesis dehydratase C-term. Lant_dehydr_C is the C-terminal domain of a family of dehydratases that are involved in the biosynthesis of lantibiotics. While the extensive N-terminal domain, pfam04738, is involved in the serine-threonine glutamylation step of the synthetic process, this C-terminal domain, once thought to be a separate domain from the dehydratase enzymic activity, is necessary for the final glutamate-elimination step in the generation of the lantibiotic. Lantibiotics are a class of peptide antibiotic that contains one or more thioether bonds.	2.23804e-63
NC_016582.1|WP_043489503.1|3048326_3049514_+|YcaO-like-family-protein	gnl|CDD|224855	COG1944, COG1944, Uncharacterized conserved protein [Function unknown].	9.40848e-65
NC_016582.1|WP_043486376.1|3044135_3046028_-|TOMM-precursor-leader-peptide-binding-protein	gnl|CDD|274674	TIGR03604, hypothetical_protein, thiazole/oxazole-forming peptide maturase, SagD family component. Members of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins.	3.39689e-93
NC_016582.1|WP_043489494.1|3011909_3012191_-|DUF1876-domain-containing-protein	gnl|CDD|378103	pfam08962, DUF1876, Domain of unknown function (DUF1876). This domain is found in a set of hypothetical bacterial proteins.	2.31309e-30
NC_016582.1|WP_043486371.1|3024964_3025933_-|helix-turn-helix-domain-containing-protein	gnl|CDD|236612	PRK09685, PRK09685, DNA-binding transcriptional activator FeaR; Provisional.	2.62243e-31
NC_016582.1|WP_014174816.1|3013547_3015791_+|MMPL-family-transporter	gnl|CDD|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	2.00886e-114
NC_016582.1|WP_014174823.1|3026150_3030866_+|RHS-repeat-protein	gnl|CDD|225750	COG3209, RhsA, Rhs family protein [Cell envelope biogenesis, outer membrane].	9.52236e-45
NC_016582.1|WP_014174817.1|3015902_3017150_+|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.41147e-46
NC_016582.1|WP_014174827.1|3038050_3039532_-|SagB-family-peptide-dehydrogenase	gnl|CDD|188352	TIGR03605, antibiot_sagB, SagB-type dehydrogenase domain. SagB of Sterptococcus pyogenes participates in the maturation of streptolysin S from a ribosomally produced precursor polypeptide. Chemically similar systems operate on highly diverse sets of bacteriocin precursors in numerous other bacteria. This model describes a domain within SgaB and homologous regions from other proteins, many of which appear to be involved in biosynthesis of secondary metabolites. While some substrates may be intermediates in non-ribosomal peptide syntheses, others are involved in heterocycle-containing bacteriocin biosynthesis, and can be found near SgaC-like (see TIGR03603, cyclodehydratase) and SgaD-like (see TIGR03604, "docking") proteins. Members of this domain family are heterogeneous in length, as many have a partial second copy of the domain represented here. The incomplete second domain scores below the cutoffs to this model in most cases.	6.0882e-49

Protein sequences

>NC_016582.1|WP_014174823.1|3026150_3030866_+|RHS-repeat-protein
MGFGDFVPDGVKDWVEDRVEDVGEAVDDAGDWTGDRLDDVGWESGADWVRDKSDAAADALGADVDEMQLGESEDPKKLIHGSSSKLRSTAGHLTDFKTAFNNVGKGLRGLGSRSLKGKAADSFRESVSVEPRKWFTAADACEKASGALERFAGTVEWAQGQAEEAIRRYKKGKKASEDARSAHNDTVGAYNRAVEAYNALPADKRDPVSLPDKPGAFHDPGAADMKAARELLAEARRQRDEAQGVAKAAVEAARDAAPEKPSYARRVGDGLEGLNLDAGHFLGGVVKGTAGLVNFARSVNPMDLYNLTHPAEYVTNLNSTAAGLLRMANDPGTALKGMWDAFQKDPSEGLGRLVPELIGTKGLGGARAAVAAAERLPATLARAERPGLQTLARDGAAPHATPDGAKTAGGTDPVDLASGRMYLPQRDVVLPGALPLVFVRRVESGYRAGRWFGPTWSSTADQRLEIGARGVVFVAEDGLLLSYPHPAPGVPTLPELGPRWPLERTVEGDYTLTDPATGRVWWFNGPEGGGDGEALLAEISDRNGHRLTFEYDTDGAPAGIVHSGGYHLKITTADGRITALHLAGADQELIRYAYTDGNLTEVINSSGLPLRFEYDVERRVIAWIDTNDRRYDYVYDNRDRCIAEGGTEGHISLHIDYGPVDERTGHRVTTVTTAEGDTTRYLVNDRCQVITVTDPLGNTVRTRRDRYGRALSRTDALGRTTGYTYDAAGRLTSLTTPDGHQRTASYNDLGLPVQVTPADGATWRYAYDERGNRIAATDPLGNTARYAYDDHGHLSSTTNALGDTTRVRCDPAGLPVEITDPLGAATTYHRDAFGRPATITDPLGATTRVEWTVEGKLSRRIAPDGAEQRWTYDGEGNLTAHRDASGGLTRYEYTHFDLLAAQTDPDGTRYEFTHDTQLRLTEVTNPQGLTWTYEYGPTGRTLSETDFDGRTLTYAYDPAGQLVSRTNPLGQTVSLERDASGRVVRKDADGQVTTFAYDLAGRLTEAVGPEVSAVFGRDRMGRVTTEMVNGQVLTRTYDALGRTVRRTTPSGAKSTFAYDAAGRRTTLTTCGHTLDFTYDAAGQETTRQLGPNAALAQIWDPAGRLSEQTLTTGPESGTLQHRAYTYRPDGHLTAIDDQLHGPRTFDLDNAGRVTTVRAQGWTETYAYDEAGNQTHATWPHEHPTPEATGPRTYTGTRITRAGRLRYEHDAAGRLTLRQKTRLTAKPDTRRYTWDAENHLTTLTTPDNTLWRYLYDPLGRRTAKQHLAPDGETVLEQTDFTWDGPTLVEQTTTTPGLPHPVTLTWEHDGFRPLTQTERTTDATTQREIDRRFFAIVTDLVGTPTELVDENGDIAWRTRTTLWGTTTEDRASTTPLRFPGQYHDPESGLHYNHHRYYDPETARYTTPDPLGLTPAPNPAAYVPNPHLFIDPLGLSPYDDFGDIDWFAPEADDAGQFASYWYVNGRPDNEMVFTGHGGIRAGDGSPVTVPEGTSVAMYSRHGEKIYHDEGTIIETRNPTPLEVYKPGEQLPDYSLFPPNGLDVTGRTVAQEVRLSKLLLPNMGRVHWSACRSVV
>NC_016582.1|WP_043486371.1|3024964_3025933_-|helix-turn-helix-domain-containing-protein
MIETLFRGDELPVAERFESWRGLAFASHSPHVIRTEHAADFRGTLRVLDLGVVQVSVFSCPPLESFRTPALIRQSDPEIYHLSVPLAGRVGVAQGGQEVVAGRGDLALVSSSHPYRGQLDATDGTVSAAEMLIPRAVLPLPGGLAERQFAMRLPGRTGMGALLAQFVTGLVTDTTPYGPSDSARLGAIALDLATALLAQQRGAQGPPETFHHALAMRVRGYIHQHLADPELSPEQIAAAQHISVRSLHRLFRHQKTTVSAYIRHQRLEQARRELADPALCMRPIHAIAARWGFRRAADFTRAFRAAYGMPPKDFRHLTGVQR
>NC_016582.1|WP_014174821.1|3023805_3024621_-|helix-turn-helix-domain-containing-protein
MRLSVLCFPALSSLLARSGDPRGWRLVLVSDGPLTLGRGSGAIRLEPGQLVLWDPWEPFDAAAADRARPPRAMVLHLPGSALSLPHHALRGLVARPVPSDSGPAALLARFLEGLAGPAAAVDIPQATWVGRAAVDLAVAFLSSVTDVLDDAARLPRQVALLREIKTYIDRNLSDPDLSPTTIAAAHHISVRYLHHLFRQDEQTVGGFVRERRLESCRADLTDPCLAGQSMAVIRARWGFQDAAVFNRAFKKEYGITPGEYRRREGVPAGVR
>NC_016582.1|WP_014174820.1|3022023_3023712_+|protein-kinase
MSERDPVHPWTGELSSADLERLGAEPLRRSDPVAIGPYRVLARLGGGGMGRLYLGREAGVEGEAAAPYGAGALVAVKVIRPEHAEDPRFRRRFEREVEVVRRVHGKYTAGLVASGFDEEERLWMVTAYVPGPSLDDTVRRFGPFPAPVVWRLADEIGEALATLAAAGIVHRDLKPSNVLLGADGARVIDFGVAHTTDASVLTMTGQHVGTPAFMSPEQADGREAGTASDVFSLGSVLAHAATGRTPFGEGSTADVIHRVVYSPPSADVLAKVTESDPALAELIGRCLDKSAEGRPSPQEVVDTARQHAPAQEWPASLAELIGARSAWSGLAAAVSPMEQLTILRRGAPERTLKPAPPKSRRGLVWAAVGTVTAVAIGVVAFAVPGMGSSDDGRKQVAATASKSAHHPRASKSSAAKHSAKPSPSATSAPANPQGGGGGNGGGSDETQPPAEQKQPTRTITKIITATPNQPKQTQPPPKTSQPKPWKSCQYYSGTALTQQGSRGAAVRQVQCILKARKYDIGPHGIDGQFGPDTKAAVIAFQRDHNLHRDGQVGEDTWPALRA
>NC_016582.1|WP_014174819.1|3021689_3021980_+|hypothetical-protein
MADDKISVDPVAHQASSKFLSIIGGGFQDAIKQLSDAGTTLSDPNHWSGPYAAQFRSSWSSAQTDLNKIRHSLDEFQRKFDTVLRNISAAGGQHQR
>NC_016582.1|WP_014174818.1|3017320_3021547_+|FHA-domain-containing-protein
MRIVYADGKTEREMELRVGRPNATLADLAAALDIPASGLSIDGRTAPPETGLGESGLAHGSRVARAGWGSAGGPRVSAAVLRVVGGLEAGRSVPLRVGRTVIGRGAEADVRVVATGVSRLHAALEISADGQVHITDLDTVNGTDVSGERISKAVRLQPEDLVSLGGEVMVRVLPQDRLGPVQRVNPVREVGPGGTLPFNRPPRGGRPGDPPLIAAPSSPPSANKAPFSIASMLGPLVMAGAIVGITRDIRYAAIAALTPLMFVGNFLEERLRGRFTFRRGMRDHTARVKEFEQAVAARHAAEIRTRRAAHPDPAEVVRRATAPGVALWERRPGAPDFLKTVVGTADLPWNPPLDTDSSEPAPEVADIVGARCVLPQVPVVVGVSAGEAVGFEGDRRAALGVARSLLCQALVGSGPADVTLAVFADPERLADWDWTKWLPHGADPQSGTSRLVAVGPEQADTLARGLLAAAPRRAEGGAGPVLLVVVDGATLLEGRPCPLRDLLADRTLRCGALVLTTRLPALCTSVVTAAPEGRGRVRDVASDEVVPDVLLGGMPVDEARATARALARFEDPELRVEGAGLPDRISLLPLLDLTAVSGAEVGGRWKTRAPALRVQAVLGVSERDLFTVDLDDDGPHALIAGTTGSGKSELLRTLIASMATDADPEHLTFALVDYKGGGALDECAELPHTVGLVTDLDEQLSERALRCLDAELRHRERLLREVGLSHIRDYQRLRDTGDGDGDMEPMPRLAVVIDEFATLVKALPDFVDSLVSIAQRGRTLGVHLIMATQRPAGSVNDAIKNNVKLRIALRLESTGDSQDVIDSSASAGIGTRQWGRAYYRLSAREVLPVQTALSTGVTPQAAVTAPVTIAPFILGMPVLTAATDGAEGETDLRRLVTAARQAAALSGFPPPRRPWPDPLPKVLHRADLPAVAEQGLHTEAAGLPAWALADDPDRQRQYAVGWDPAAGNIVVYGGGGAGTSTALAALALSVAGSCPPDRHHIFALDLGAGDLAPLAALPHTGAHIGSGERERQIRLIKLLRRELDARKARGPAGSPDWLVLLDNLGALLSDFDKDVAGMNLIEELARVYADGPAVGIRFAVSADRSGAVPTAWSALTQTKLLLRLADPGEYGYFDVPRNAVPSYVPGRALVAANRQVIQIGWPGEDLAAAVAETAARWTGAQRSAPEVGLLPTDVPATALTAPAQTATDPWWLPVGLDSDTLGCAGLRLYEREHALIAGPQRSGRSTALCTLARLVTASASTDTPTTVVGFAPRRSPLRDLPGLTALATTYDDLEQTLTALPPGRPVLLLADDVDTVEDERGFLEQWLSFPATGHHMIAAGRADTLRRSYGHWTQRTRDSRCGVLLCPDHDLDGDLLGTQLPRHDRMAPLPGRGYLVVDGVAAGVQVAN
>NC_016582.1|WP_014174817.1|3015902_3017150_+|sensor-histidine-kinase
MTSSLERYTERHHRAFDLIVAGVLFGLVVLGAALSTPGTTQPTLGPAVLLGGISCAALVGCRSHPRTALAVTAVCAAAASAVGYLLTPLLLAPAMTALYWLATLAERKISYAYCLATIAALVTTAMIADPGHHALVLKTIGPAVWLLLPVAAGRAVRMRRAYMDAVMDAAQARAEHAERTREEEARHRVAEERMRIARELHDVVAHHLALANAQASTAAHLARNHPDQAHKILTGLASTTSSALRELKATVGLLRRTDDPDAPLEPSPGLDRLPELTDAFASAGLPVTVTTRGEPRRLSPGVDLTAFRIVQEALTNVTKHAAAHTAHVRLDYARDRLTISVTDDGTTTAATATEATAAPAPGHGFGLIGMRERAHSVGGALTAGCRPEGGFEVTAELPLHPDGPPPSPEPEVRQT
>NC_016582.1|WP_014174816.1|3013547_3015791_+|MMPL-family-transporter
MAAFLYRLGRLAFRRRWWVTLLWVAVLAVVGFGAVKAPAAPDTGNAMPGIESQKAFDLMDQRFPGAKADGASARIVFVAPHGEKVTAADNRAAVEKVVHEVADGRQVAGAVDPFQARAVSKDAGTAYATVTYKVKADDLTDASKKTLEDAVQQARDAGLTVEVGGNALATQPAAGGAAEGIGIAIAAVVLLITFGSLAAAGLPLLTAVVGVGISIASIMALASTFGLSGTTGTLASMLGLAVGIDYAMFVVSRYREERARGHEPEEAAGLAAGTAGSAVVFAGLTVVIALAGLSVVGIPLLTKMGLAAAGAVAVGVLIALTLIPALLGFLPRAVLSRSARRGAKAKEAKEGSEHNGGSRWARFVLRRPLPVLLACVAGLGAIAIPVTGLQLGMPGDEAKPTSATERRAYDALAEGFGPGFNGPLTIVVDAKDTGDANSTADTKAAARTIADRIAATKGVVSVSPPRLNAAGDTAVFSATPATAPTDEKTKDLVRTIRAERPALESATHASFEVTGSTAVNIDVAQKVQDALIPYLAVVVGLAFLLLLVVFRSLLVPLKAAAGFLLSVLAAFGAVVAVFQWGWGASLLGVEQTGPIISLMPISLVGIVFGLAMDYEVFLVTRMREAYVHGDRPGQAIVTGFRHSARVVVAAALIMMAVFSGFVGSAESMIKMMGFGLAIAVLFDAFVVRMALVPAVLALLGDRAWWLPRWLDKVLPNIDVEGEALSRRSPVAAVPAPDTTSERESARV
>NC_016582.1|WP_014174814.1|3012304_3012559_-|hypothetical-protein
MAVGLALFGGPVAVAATSAPTGHHAEATSSTVMDYYQYFGHYTTHEECVAVGEEYLWPHNPGGADAYECRAKDGGWDLWLIFAT
>NC_016582.1|WP_043489494.1|3011909_3012191_-|DUF1876-domain-containing-protein
MPQTTVGWHVELEFTEAPRHTRAAALVRLADGSEVRGHGAASRAPVDANQPRVGEEIAGARALNELATKLLEKAHGEIDAVSGRASHPLHLNH
>NC_016582.1|WP_014174825.1|3035669_3036092_+|hypothetical-protein
MTHYADLSPYAYPAGSVPEGIEAVNAGWLEPGEEFPRGTVPEEFVRSLALLCRDDPQMQMRGWHRCALPHLDGKDEYPVVIQVGEDRISLGSAEVRVVGRDGRWLIAPNLVHHYVTAHSYLPPEEFIDAVTAHRTTAPMA
>NC_016582.1|WP_043486373.1|3036142_3037741_-|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MSRPADRVNRLTRAWIWPLVIGLAATLSWSSPAGADTSRADLGTALDTLLADPLLKGGAAGVVVADADSGAVLYQHHPDDRLMPASNTKLFTSAAAMGLLGPDYTYRTDVLTDGSRQGRVLRGDLYLRGTGDPTMLAADYERLAAQLAESGITRVTGRLIADDTRFDTQRAGRSWAADDESSYYAAQISPLTLAPDTDYDAGSIIVETAPGAAPGEKPKVTLTPKTDYLRIDNRATTAATGSGSTLSVERQHGSNTITVSGALPAGSSPAKEWVSVWEPTGYATSVFADALARHGVHVTGATRLGRATPPDARSLASHESMPLKKLLIPFMKLSNNIHAEVLAKTIGYETAGRGTWSAGLDAVSDWLKKRGVDTGSVRQVDGSGLSRMDNIAAGRLTELLLSVRDEPWYADWYASLPVACDPDRFVGGTLRSRMCGTPAARNARGKTGSLTGASALSGYVTDADGRELAYSVVLNNFLAPSVKSLEDAIVVTLAKSGADRATAVRPSAVPNATAERAGAADLECSWVKPRRC
>NC_016582.1|WP_014174827.1|3038050_3039532_-|SagB-family-peptide-dehydrogenase
MSPLLLSLYPGTALHDHQGLLTVRHRWGRTPLGPHTPPLAEALHTLAAGPTAIDEMADRINARAESCGLPPEPQLALFHHCLDRLGHTLQRHATHGSRPLATAVPLAPEAAPRPGPVPDTPLTLDRAAHLRPVDGQLALESPRSRFRVRVEDPRTATPLALLARPASRAELGRHCHELPEGALTALLTLLHSTGFLHPVGDAGRDAGRADTADLPSGWSFHELLAYDGARAGPRDRLYGPVFPLRDTEPPPPPVPRPATGRTIPLRRPDLDRAAREDRTFTDVLESRASRRTYGERPLTRDQLGELLYRAARVRTVLAARPEDDRPYAVTSRPYPSAGSAYELELYAAVHRCQGLDRGLYHYNPLGHALTALPGAPGAVDGLLREASAATGAAPPPDVHLTLVSRIKRLSWKYAAHSYALTLKNTGVLLQTLSLVATAMGLSGCAVGGGDSETPVRAFGLAAHTEIPVGAFLLGSAAADGPNYATPPASTRRR
>NC_016582.1|WP_014174828.1|3039528_3040575_-|lantibiotic-biosynthesis-protein
MSRPSDPPTPPGQWVAVHLFHQGDLDTLLLDAVAPALTGLAQAGRIHGHFFLRYWEGGPHLRVRVLSGEPAHPVHNGSQDIATELVDRWNAWLKEHPSPRSVDEAAYLRFATEAAAREGLPGYEPWRGLHDEAEVRGYLPEHDRYGTGAPLAAVERHFMEASRCAEAVLARRPGPAERLSAGFAVSLLTWAVVEPDPQRRLDALRAGAEAWRRMLGPAYDTEAFDRAYESGRGALVRRAGHLLAPAPRPRSDGPTGPIAAWRHSVSRLHASLEALERKGEFTPDLGALRDDPSLLDLPSPRAALTANRCAHLMCNRLGLYGPQEALLRHFAARAAADLHTAGSGAHRP
>NC_016582.1|WP_014174829.1|3040558_3043126_-|lantibiotic-dehydratase
MNTPPDPVVRVAGVPRSTLAVLNTPKSFELAEHILQTREQVAEEGRRIADALHLVIGALPEPALRPRVIGLRRAVHQGRSPRAAEWNTDVRAALPGPLVGRIRGWLDRRAQCGEHTESLAAVLQEETHDSLAALREDLAHPRFRQGLLHATPELDDVLERWIAAPGHPTPGTKALVSLARYLSRAAVKTSPQGTFTATGQGRWTAHGPWLHTGDLERRTTTAELNLARLRRIADGLLRAHPALRDTLRLRLNPALNVADGTLRLIAPGPGARVTAFPAVDRTPRLLDTLSNLDGATVAEAGPGVRRFVAAGILQEDLPLDDLEPCHLDALITWLTGNGLTDNGPTDNGPSALQGTLDALAALRSALPRRPRPADHAERRDQARAARDRLLAVEGALGLPAPGEPYERRPVHEDSVLDGTAVTLGHGPWRPLLADLASVGRALAVLDRDLPARYAVAAWLAERHGPHPHVPLLLVLHELREDPSPTAEHVRALLRPGFGVDDTFLRDSPLPVLRRLTDHRATVLQALRAGELATDVAAPRPPLSLAHYIQPLPGPDGRPRAVLNAVTVGHSHWQGRLDRMRARATDGPVPPSPAPDTRTGRGRIPVDIGGLYASNTNLRHPTLPHAFDHPFTRGARSGPGRIPLGEVTVRLDRATGLPALRSPRCDADLVPVHLGLMSPLLLPPPLATLLRLFGDPHTLFRTGHPLLPGPFADDVPDRGVVSLDRIEAGRVVLRRRSWLTRAGSVPRRTPGERDHEHFLRLLAWRRELGLPASCFVRTRAPGSHGADAFADKGYKPAYIDFASPLLTTAFTRSLGSPDTVVHIEEALPDPAAPDGDTPYTSEFVIELPGDFHEPAV
>NC_016582.1|WP_014174830.1|3043122_3044139_-|hypothetical-protein
MTGHHPGAVQLPPPPALGTVDHALWAARRCTCHTGTPRPAPLPRWAAVLGHACGVGPFEARPDERPGLRGHLGETRVTAGANTPITPGSYAYEPVAHQLVPMRMDHARTYDGALALHLDDDTGETTACVRLVAAACGLCTHTAGPDTLLLYASSTTTPTAGDMEDALAALPVEPPVYTAALGRLTASDLLTLLHKAAPDPPYRVTVRSVDGMDAGVYRADAAQGPLEPVWHGPTAPYAHVLTRGGHPDAAALAGAAAIVHLVGGHGTPRAADALRVRVAASAAGLAAWCDDAPTPAATTLLGLIPGVADVTCHITIGRAWPEPRLRIPVRLATSGALP
>NC_016582.1|WP_043486376.1|3044135_3046028_-|TOMM-precursor-leader-peptide-binding-protein
MRPTELRAAVVGDGGLLNQAIAERLTSERLASGRDLRTHAVLLTVSDGWESDAAHDRHRRRALASGVPWLPVWTEGARALIGPLVRPDAPGCHRCLRMRRAHAREDWPVVRAVRERYATEPEPERSPLLTTVAAEITAHLVAARLMAAAIPSRELTVIGLRTLDVSSHTFLPDPCCPECGGLPDDSPQAAPRTLRPRPKPRPGHRLRRPDATRLRAALADPETGLLREVSAVSAGVPLARAPLTLPGGGEFEAGLGTGDEWGAAQAAALLEGVERYASVRPRARRAAVRAAYAEVREDAVDPRTLGLHPDGHYDLPGFPFRRFDEAAVTEWVWGWSYGRDRPLLLPQSYVYFLSATERDRAFAFEVSNGCALGSCLEEAQLHGLLEVAERDAFFTTWYRRTPLDAIDPDSARDRTVPLLAEHLTQLTGHRVHLLDATQEQHIPCVVALAVDEDERPDTPRAAVAAGAHPDPEQAAVRALMELVPHLTLLTSRYRAERERARQLALDPSLIAHPADHALAAAAPEAFVRLAFLRGGKPPRTFTEVHRGRHLPRYHGDLTDDLRDLIRRYLETGLDVIAVDQTPAEVSALDLAAAKVVVPGTAAVTYGPLMRRTEGLPRLTGHLSADPHPFP
>NC_016582.1|WP_014174832.1|3046014_3047925_-|hypothetical-protein
MGGRRLKLVRQVRYAPTENGAAVLGPSGALALRGAGVYAWLERLWPLLDGAQDVDAVLAQLPDGHRAVATRLLETLQRRDFLREATEPRPHGLTVTELHRHRHEIAYIGHWLDSPEHRFERYRTARVLLLGDGPLYAATRHALLACGLRQVQVLTEDASAPYDTLRAAARTADAVVFTRDATTPQAGPGVAAVERACGGVPLFRALSRPADCWLLPPTAPLTWADVRHRIRHTAAPDSAGPIPMTAAAAALVGGRLALAVFRLLTGVPDEDTDVDADAPGPVPGILRVDLTTLAAHRHRVLPAPRRHDSACAEGRMKELREAPALDPDELTARLADCADDIAGPYAPPTMEYGSQIPLTVAQCVVAGAGVVVGASLDPRAAKAVALRRAGASYALSAAGYVPPQPSDQAAPDPARFRAERLTDGGVRSLPASLVLPCPAGEGQQGGRPVGAGTACAESWDAAVEAALFAAVRSLARQRAADLPSATLMPEGLLTEPEAVRHWRLLCTLGPVPEARDLSGGLVAPVIGLVAGDRLASVGCAATAAGALAEAARELLLARQRGTEPAAGALPLPTASGPPTSHVPASLPGSLPQERIAHLGTSLAAEGYTAYAVPLDHDADFHALVPFIARVVLDEAH
>NC_016582.1|WP_014174833.1|3047994_3048147_-|hypothetical-protein
MENTSLLDLEQLGDEMFEVVESDTTEDKGGAGSAWAYACCHSASSSCALS
>NC_016582.1|WP_043489503.1|3048326_3049514_+|YcaO-like-family-protein
MKKVHFDGTHRVRHPEETWTLINGLRDRFGITRVADVTGLDTLGVPVVMAVRPAAKTLTVSQGKGASLLLARVSAVMESVELWHAEYACPAPELKHTPACELELPYDVCDLQQHHGSLLSERTPLDWVIGVDAVSGTKTLVPRAYVRVDYQVSRAWQPPLLHGSTNGLAGGNTYDEALAHALYEVIERDCTATIGSLPVAERRHVDPSSVDDPLCATVLGRIADAGAWVEIVEVPNRWGLPCFVSYIWSEDFPALAVGSGVHGSPAVALSRALTESAQSRLTAIAGSRDDLAAVLFAGGPSAAGPPPVTEGEFVPWQDVSGRGREFAEDTEETRWLAGEVHRVTGRPPVAVDLSTESGFSVVKVVAAGLEFDGRHEIPRPLTAASSSATNPKGGS

Crispr_ID: NC_016582_4

• CRISPR_ID: NC_016582_4
• CRISPR_location: 3033224-3033439
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NC_016582_4

Consensus_repeat	Method
ATCACCGACCCCCTCGGCGCGACCACC	CRISPRCasFinder

spacers of NC_016582_4

>4.1|3033251|36|NC_016582|CRISPRCasFinder
CGCCACACCTACGACGGCCACGGCCATCTGGCCTCG
>4.2|3033314|36|NC_016582|CRISPRCasFinder
CGCGTCCGCTGCGACCCGGCCGGGCTCCCCGTCGAG
>4.3|3033377|36|NC_016582|CRISPRCasFinder
ACCTACCACCGCGACGCCTTCGGCCGCCCCACCGCC

CRISPR arrays and Neighbor proteins around NC_016582_4

CRISPR arrays

The CRISPR arrays of NC_016582_4

>merge|NC_016582|4|3033224-3033439|CRISPRCasFinder
GCCACCGACCCGTTGGGCCACACCACCCGCCACACCTACGACGGCCACGGCCATCTGGCCTCGGTCACCAACCCGCTCGGCGACACCACGCGCGTCCGCTGCGACCCGGCCGGGCTCCCCGTCGAGATCACCGACCCCCTCGGCGCGACCACCACCTACCACCGCGACGCCTTCGGCCGCCCCACCGCCATCACCGACCCCCTCGGCGCCACCACC

>NC_016582|4|3|3033224-3033439|CRISPRCasFinder
GCCACCGACCCGTTGGGCCACACCACC	CGCCACACCTACGACGGCCACGGCCATCTGGCCTCG
GTCACCAACCCGCTCGGCGACACCACG	CGCGTCCGCTGCGACCCGGCCGGGCTCCCCGTCGAG
ATCACCGACCCCCTCGGCGCGACCACC	ACCTACCACCGCGACGCCTTCGGCCGCCCCACCGCC
ATCACCGACCCCCTCGGCGCCACCACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014174828.1|3039528_3040575_-|lantibiotic-biosynthesis-protein	unknown	unknown	gnl|CDD|372883
NC_016582.1|WP_014174829.1|3040558_3043126_-|lantibiotic-dehydratase	unknown	unknown	gnl|CDD|377403
NC_016582.1|WP_014174821.1|3023805_3024621_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|236612
NC_016582.1|WP_043486373.1|3036142_3037741_-|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl|CDD|334815
NC_016582.1|WP_014174832.1|3046014_3047925_-|hypothetical-protein	unknown	unknown	gnl|CDD|163405
NC_016582.1|WP_014174818.1|3017320_3021547_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|274860
NC_016582.1|WP_014174825.1|3035669_3036092_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014174830.1|3043122_3044139_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014174820.1|3022023_3023712_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NC_016582.1|WP_014174814.1|3012304_3012559_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_043489503.1|3048326_3049514_+|YcaO-like-family-protein	unknown	unknown	gnl|CDD|224855
NC_016582.1|WP_014174833.1|3047994_3048147_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_043486376.1|3044135_3046028_-|TOMM-precursor-leader-peptide-binding-protein	unknown	unknown	gnl|CDD|274674
NC_016582.1|WP_043489494.1|3011909_3012191_-|DUF1876-domain-containing-protein	unknown	unknown	gnl|CDD|378103
NC_016582.1|WP_043486371.1|3024964_3025933_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|236612
NC_016582.1|WP_014174816.1|3013547_3015791_+|MMPL-family-transporter	unknown	unknown	gnl|CDD|225272
NC_016582.1|WP_014174823.1|3026150_3030866_+|RHS-repeat-protein	unknown	unknown	gnl|CDD|225750
NC_016582.1|WP_014174819.1|3021689_3021980_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014174817.1|3015902_3017150_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NC_016582.1|WP_014174827.1|3038050_3039532_-|SagB-family-peptide-dehydrogenase	unknown	unknown	gnl|CDD|188352

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014174829.1|3040558_3043126_-|lantibiotic-dehydratase	gnl|CDD|377403	pfam04738, Lant_dehydr_N, Lantibiotic dehydratase, C-terminus. Lantibiotics are ribosomally synthesized antimicrobial agents derived from ribosomally synthesized peptides. They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues. This family constitutes the N-terminus of the enzyme proposed to catalyze the dehydration step, via glutamylation of the substrate during lantibiotic biosynthesis. The enzyme dehydrates Ser/Thr residues in the precursor by glutamylation.	1.96396e-25
NC_016582.1|WP_014174821.1|3023805_3024621_-|helix-turn-helix-domain-containing-protein	gnl|CDD|236612	PRK09685, PRK09685, DNA-binding transcriptional activator FeaR; Provisional.	2.8043e-25
NC_016582.1|WP_043486373.1|3036142_3037741_-|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl|CDD|334815	pfam02113, Peptidase_S13, D-Ala-D-Ala carboxypeptidase 3 (S13) family.	1.4439e-125
NC_016582.1|WP_014174832.1|3046014_3047925_-|hypothetical-protein	gnl|CDD|163405	TIGR03693, ocin_ThiF_like, putative thiazole-containing bacteriocin maturation protein. Members of this protein family are found in a three-gene operon in Bacillus anthracis and related Bacillus species, where the other two genes are clearly identified with maturation of a putative thiazole-containing bacteriocin precursor. While there is no detectable pairwise sequence similarity between members of this family and the proposed cyclodehydratases such as SagC of Streptococcus pyogenes (see family TIGR03603), both families show similarity through PSI-BLAST to ThiF, a protein involved in biosynthesis of the thiazole moiety for thiamine biosynthesis. This family, therefore, may contribute to cyclodehydratase function in heterocycle-containing bacteriocin biosyntheses. In Bacillus licheniformis ATCC 14580, the bacteriocin precursor gene is adjacent to the gene for this protein. [Cellular processes, Toxin production and resistance].	1.04681e-16
NC_016582.1|WP_014174818.1|3017320_3021547_+|FHA-domain-containing-protein	gnl|CDD|274860	TIGR03928, T7_EssCb_Firm, type VII secretion protein EssC, C-terminal domain. This model describes the C-terminal domain, or longer subunit, of the Firmicutes type VII secretion protein EssC. This protein (homologous to EccC in Actinobacteria) and the WXG100 target proteins are the only homologous parts of type VII secretion between Firmicutes and Actinobacteria. [Protein fate, Protein and peptide secretion and trafficking].	1.85321e-139
NC_016582.1|WP_014174820.1|3022023_3023712_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.7819e-76
NC_016582.1|WP_014174828.1|3039528_3040575_-|lantibiotic-biosynthesis-protein	gnl|CDD|372883	pfam14028, Lant_dehydr_C, Lantibiotic biosynthesis dehydratase C-term. Lant_dehydr_C is the C-terminal domain of a family of dehydratases that are involved in the biosynthesis of lantibiotics. While the extensive N-terminal domain, pfam04738, is involved in the serine-threonine glutamylation step of the synthetic process, this C-terminal domain, once thought to be a separate domain from the dehydratase enzymic activity, is necessary for the final glutamate-elimination step in the generation of the lantibiotic. Lantibiotics are a class of peptide antibiotic that contains one or more thioether bonds.	2.23804e-63
NC_016582.1|WP_043489503.1|3048326_3049514_+|YcaO-like-family-protein	gnl|CDD|224855	COG1944, COG1944, Uncharacterized conserved protein [Function unknown].	9.40848e-65
NC_016582.1|WP_043486376.1|3044135_3046028_-|TOMM-precursor-leader-peptide-binding-protein	gnl|CDD|274674	TIGR03604, hypothetical_protein, thiazole/oxazole-forming peptide maturase, SagD family component. Members of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins.	3.39689e-93
NC_016582.1|WP_043489494.1|3011909_3012191_-|DUF1876-domain-containing-protein	gnl|CDD|378103	pfam08962, DUF1876, Domain of unknown function (DUF1876). This domain is found in a set of hypothetical bacterial proteins.	2.31309e-30
NC_016582.1|WP_043486371.1|3024964_3025933_-|helix-turn-helix-domain-containing-protein	gnl|CDD|236612	PRK09685, PRK09685, DNA-binding transcriptional activator FeaR; Provisional.	2.62243e-31
NC_016582.1|WP_014174816.1|3013547_3015791_+|MMPL-family-transporter	gnl|CDD|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	2.00886e-114
NC_016582.1|WP_014174823.1|3026150_3030866_+|RHS-repeat-protein	gnl|CDD|225750	COG3209, RhsA, Rhs family protein [Cell envelope biogenesis, outer membrane].	9.52236e-45
NC_016582.1|WP_014174817.1|3015902_3017150_+|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.41147e-46
NC_016582.1|WP_014174827.1|3038050_3039532_-|SagB-family-peptide-dehydrogenase	gnl|CDD|188352	TIGR03605, antibiot_sagB, SagB-type dehydrogenase domain. SagB of Sterptococcus pyogenes participates in the maturation of streptolysin S from a ribosomally produced precursor polypeptide. Chemically similar systems operate on highly diverse sets of bacteriocin precursors in numerous other bacteria. This model describes a domain within SgaB and homologous regions from other proteins, many of which appear to be involved in biosynthesis of secondary metabolites. While some substrates may be intermediates in non-ribosomal peptide syntheses, others are involved in heterocycle-containing bacteriocin biosynthesis, and can be found near SgaC-like (see TIGR03603, cyclodehydratase) and SgaD-like (see TIGR03604, "docking") proteins. Members of this domain family are heterogeneous in length, as many have a partial second copy of the domain represented here. The incomplete second domain scores below the cutoffs to this model in most cases.	6.0882e-49

Protein sequences

>NC_016582.1|WP_014174823.1|3026150_3030866_+|RHS-repeat-protein
MGFGDFVPDGVKDWVEDRVEDVGEAVDDAGDWTGDRLDDVGWESGADWVRDKSDAAADALGADVDEMQLGESEDPKKLIHGSSSKLRSTAGHLTDFKTAFNNVGKGLRGLGSRSLKGKAADSFRESVSVEPRKWFTAADACEKASGALERFAGTVEWAQGQAEEAIRRYKKGKKASEDARSAHNDTVGAYNRAVEAYNALPADKRDPVSLPDKPGAFHDPGAADMKAARELLAEARRQRDEAQGVAKAAVEAARDAAPEKPSYARRVGDGLEGLNLDAGHFLGGVVKGTAGLVNFARSVNPMDLYNLTHPAEYVTNLNSTAAGLLRMANDPGTALKGMWDAFQKDPSEGLGRLVPELIGTKGLGGARAAVAAAERLPATLARAERPGLQTLARDGAAPHATPDGAKTAGGTDPVDLASGRMYLPQRDVVLPGALPLVFVRRVESGYRAGRWFGPTWSSTADQRLEIGARGVVFVAEDGLLLSYPHPAPGVPTLPELGPRWPLERTVEGDYTLTDPATGRVWWFNGPEGGGDGEALLAEISDRNGHRLTFEYDTDGAPAGIVHSGGYHLKITTADGRITALHLAGADQELIRYAYTDGNLTEVINSSGLPLRFEYDVERRVIAWIDTNDRRYDYVYDNRDRCIAEGGTEGHISLHIDYGPVDERTGHRVTTVTTAEGDTTRYLVNDRCQVITVTDPLGNTVRTRRDRYGRALSRTDALGRTTGYTYDAAGRLTSLTTPDGHQRTASYNDLGLPVQVTPADGATWRYAYDERGNRIAATDPLGNTARYAYDDHGHLSSTTNALGDTTRVRCDPAGLPVEITDPLGAATTYHRDAFGRPATITDPLGATTRVEWTVEGKLSRRIAPDGAEQRWTYDGEGNLTAHRDASGGLTRYEYTHFDLLAAQTDPDGTRYEFTHDTQLRLTEVTNPQGLTWTYEYGPTGRTLSETDFDGRTLTYAYDPAGQLVSRTNPLGQTVSLERDASGRVVRKDADGQVTTFAYDLAGRLTEAVGPEVSAVFGRDRMGRVTTEMVNGQVLTRTYDALGRTVRRTTPSGAKSTFAYDAAGRRTTLTTCGHTLDFTYDAAGQETTRQLGPNAALAQIWDPAGRLSEQTLTTGPESGTLQHRAYTYRPDGHLTAIDDQLHGPRTFDLDNAGRVTTVRAQGWTETYAYDEAGNQTHATWPHEHPTPEATGPRTYTGTRITRAGRLRYEHDAAGRLTLRQKTRLTAKPDTRRYTWDAENHLTTLTTPDNTLWRYLYDPLGRRTAKQHLAPDGETVLEQTDFTWDGPTLVEQTTTTPGLPHPVTLTWEHDGFRPLTQTERTTDATTQREIDRRFFAIVTDLVGTPTELVDENGDIAWRTRTTLWGTTTEDRASTTPLRFPGQYHDPESGLHYNHHRYYDPETARYTTPDPLGLTPAPNPAAYVPNPHLFIDPLGLSPYDDFGDIDWFAPEADDAGQFASYWYVNGRPDNEMVFTGHGGIRAGDGSPVTVPEGTSVAMYSRHGEKIYHDEGTIIETRNPTPLEVYKPGEQLPDYSLFPPNGLDVTGRTVAQEVRLSKLLLPNMGRVHWSACRSVV
>NC_016582.1|WP_043486371.1|3024964_3025933_-|helix-turn-helix-domain-containing-protein
MIETLFRGDELPVAERFESWRGLAFASHSPHVIRTEHAADFRGTLRVLDLGVVQVSVFSCPPLESFRTPALIRQSDPEIYHLSVPLAGRVGVAQGGQEVVAGRGDLALVSSSHPYRGQLDATDGTVSAAEMLIPRAVLPLPGGLAERQFAMRLPGRTGMGALLAQFVTGLVTDTTPYGPSDSARLGAIALDLATALLAQQRGAQGPPETFHHALAMRVRGYIHQHLADPELSPEQIAAAQHISVRSLHRLFRHQKTTVSAYIRHQRLEQARRELADPALCMRPIHAIAARWGFRRAADFTRAFRAAYGMPPKDFRHLTGVQR
>NC_016582.1|WP_014174821.1|3023805_3024621_-|helix-turn-helix-domain-containing-protein
MRLSVLCFPALSSLLARSGDPRGWRLVLVSDGPLTLGRGSGAIRLEPGQLVLWDPWEPFDAAAADRARPPRAMVLHLPGSALSLPHHALRGLVARPVPSDSGPAALLARFLEGLAGPAAAVDIPQATWVGRAAVDLAVAFLSSVTDVLDDAARLPRQVALLREIKTYIDRNLSDPDLSPTTIAAAHHISVRYLHHLFRQDEQTVGGFVRERRLESCRADLTDPCLAGQSMAVIRARWGFQDAAVFNRAFKKEYGITPGEYRRREGVPAGVR
>NC_016582.1|WP_014174820.1|3022023_3023712_+|protein-kinase
MSERDPVHPWTGELSSADLERLGAEPLRRSDPVAIGPYRVLARLGGGGMGRLYLGREAGVEGEAAAPYGAGALVAVKVIRPEHAEDPRFRRRFEREVEVVRRVHGKYTAGLVASGFDEEERLWMVTAYVPGPSLDDTVRRFGPFPAPVVWRLADEIGEALATLAAAGIVHRDLKPSNVLLGADGARVIDFGVAHTTDASVLTMTGQHVGTPAFMSPEQADGREAGTASDVFSLGSVLAHAATGRTPFGEGSTADVIHRVVYSPPSADVLAKVTESDPALAELIGRCLDKSAEGRPSPQEVVDTARQHAPAQEWPASLAELIGARSAWSGLAAAVSPMEQLTILRRGAPERTLKPAPPKSRRGLVWAAVGTVTAVAIGVVAFAVPGMGSSDDGRKQVAATASKSAHHPRASKSSAAKHSAKPSPSATSAPANPQGGGGGNGGGSDETQPPAEQKQPTRTITKIITATPNQPKQTQPPPKTSQPKPWKSCQYYSGTALTQQGSRGAAVRQVQCILKARKYDIGPHGIDGQFGPDTKAAVIAFQRDHNLHRDGQVGEDTWPALRA
>NC_016582.1|WP_014174819.1|3021689_3021980_+|hypothetical-protein
MADDKISVDPVAHQASSKFLSIIGGGFQDAIKQLSDAGTTLSDPNHWSGPYAAQFRSSWSSAQTDLNKIRHSLDEFQRKFDTVLRNISAAGGQHQR
>NC_016582.1|WP_014174818.1|3017320_3021547_+|FHA-domain-containing-protein
MRIVYADGKTEREMELRVGRPNATLADLAAALDIPASGLSIDGRTAPPETGLGESGLAHGSRVARAGWGSAGGPRVSAAVLRVVGGLEAGRSVPLRVGRTVIGRGAEADVRVVATGVSRLHAALEISADGQVHITDLDTVNGTDVSGERISKAVRLQPEDLVSLGGEVMVRVLPQDRLGPVQRVNPVREVGPGGTLPFNRPPRGGRPGDPPLIAAPSSPPSANKAPFSIASMLGPLVMAGAIVGITRDIRYAAIAALTPLMFVGNFLEERLRGRFTFRRGMRDHTARVKEFEQAVAARHAAEIRTRRAAHPDPAEVVRRATAPGVALWERRPGAPDFLKTVVGTADLPWNPPLDTDSSEPAPEVADIVGARCVLPQVPVVVGVSAGEAVGFEGDRRAALGVARSLLCQALVGSGPADVTLAVFADPERLADWDWTKWLPHGADPQSGTSRLVAVGPEQADTLARGLLAAAPRRAEGGAGPVLLVVVDGATLLEGRPCPLRDLLADRTLRCGALVLTTRLPALCTSVVTAAPEGRGRVRDVASDEVVPDVLLGGMPVDEARATARALARFEDPELRVEGAGLPDRISLLPLLDLTAVSGAEVGGRWKTRAPALRVQAVLGVSERDLFTVDLDDDGPHALIAGTTGSGKSELLRTLIASMATDADPEHLTFALVDYKGGGALDECAELPHTVGLVTDLDEQLSERALRCLDAELRHRERLLREVGLSHIRDYQRLRDTGDGDGDMEPMPRLAVVIDEFATLVKALPDFVDSLVSIAQRGRTLGVHLIMATQRPAGSVNDAIKNNVKLRIALRLESTGDSQDVIDSSASAGIGTRQWGRAYYRLSAREVLPVQTALSTGVTPQAAVTAPVTIAPFILGMPVLTAATDGAEGETDLRRLVTAARQAAALSGFPPPRRPWPDPLPKVLHRADLPAVAEQGLHTEAAGLPAWALADDPDRQRQYAVGWDPAAGNIVVYGGGGAGTSTALAALALSVAGSCPPDRHHIFALDLGAGDLAPLAALPHTGAHIGSGERERQIRLIKLLRRELDARKARGPAGSPDWLVLLDNLGALLSDFDKDVAGMNLIEELARVYADGPAVGIRFAVSADRSGAVPTAWSALTQTKLLLRLADPGEYGYFDVPRNAVPSYVPGRALVAANRQVIQIGWPGEDLAAAVAETAARWTGAQRSAPEVGLLPTDVPATALTAPAQTATDPWWLPVGLDSDTLGCAGLRLYEREHALIAGPQRSGRSTALCTLARLVTASASTDTPTTVVGFAPRRSPLRDLPGLTALATTYDDLEQTLTALPPGRPVLLLADDVDTVEDERGFLEQWLSFPATGHHMIAAGRADTLRRSYGHWTQRTRDSRCGVLLCPDHDLDGDLLGTQLPRHDRMAPLPGRGYLVVDGVAAGVQVAN
>NC_016582.1|WP_014174817.1|3015902_3017150_+|sensor-histidine-kinase
MTSSLERYTERHHRAFDLIVAGVLFGLVVLGAALSTPGTTQPTLGPAVLLGGISCAALVGCRSHPRTALAVTAVCAAAASAVGYLLTPLLLAPAMTALYWLATLAERKISYAYCLATIAALVTTAMIADPGHHALVLKTIGPAVWLLLPVAAGRAVRMRRAYMDAVMDAAQARAEHAERTREEEARHRVAEERMRIARELHDVVAHHLALANAQASTAAHLARNHPDQAHKILTGLASTTSSALRELKATVGLLRRTDDPDAPLEPSPGLDRLPELTDAFASAGLPVTVTTRGEPRRLSPGVDLTAFRIVQEALTNVTKHAAAHTAHVRLDYARDRLTISVTDDGTTTAATATEATAAPAPGHGFGLIGMRERAHSVGGALTAGCRPEGGFEVTAELPLHPDGPPPSPEPEVRQT
>NC_016582.1|WP_014174816.1|3013547_3015791_+|MMPL-family-transporter
MAAFLYRLGRLAFRRRWWVTLLWVAVLAVVGFGAVKAPAAPDTGNAMPGIESQKAFDLMDQRFPGAKADGASARIVFVAPHGEKVTAADNRAAVEKVVHEVADGRQVAGAVDPFQARAVSKDAGTAYATVTYKVKADDLTDASKKTLEDAVQQARDAGLTVEVGGNALATQPAAGGAAEGIGIAIAAVVLLITFGSLAAAGLPLLTAVVGVGISIASIMALASTFGLSGTTGTLASMLGLAVGIDYAMFVVSRYREERARGHEPEEAAGLAAGTAGSAVVFAGLTVVIALAGLSVVGIPLLTKMGLAAAGAVAVGVLIALTLIPALLGFLPRAVLSRSARRGAKAKEAKEGSEHNGGSRWARFVLRRPLPVLLACVAGLGAIAIPVTGLQLGMPGDEAKPTSATERRAYDALAEGFGPGFNGPLTIVVDAKDTGDANSTADTKAAARTIADRIAATKGVVSVSPPRLNAAGDTAVFSATPATAPTDEKTKDLVRTIRAERPALESATHASFEVTGSTAVNIDVAQKVQDALIPYLAVVVGLAFLLLLVVFRSLLVPLKAAAGFLLSVLAAFGAVVAVFQWGWGASLLGVEQTGPIISLMPISLVGIVFGLAMDYEVFLVTRMREAYVHGDRPGQAIVTGFRHSARVVVAAALIMMAVFSGFVGSAESMIKMMGFGLAIAVLFDAFVVRMALVPAVLALLGDRAWWLPRWLDKVLPNIDVEGEALSRRSPVAAVPAPDTTSERESARV
>NC_016582.1|WP_014174814.1|3012304_3012559_-|hypothetical-protein
MAVGLALFGGPVAVAATSAPTGHHAEATSSTVMDYYQYFGHYTTHEECVAVGEEYLWPHNPGGADAYECRAKDGGWDLWLIFAT
>NC_016582.1|WP_043489494.1|3011909_3012191_-|DUF1876-domain-containing-protein
MPQTTVGWHVELEFTEAPRHTRAAALVRLADGSEVRGHGAASRAPVDANQPRVGEEIAGARALNELATKLLEKAHGEIDAVSGRASHPLHLNH
>NC_016582.1|WP_014174825.1|3035669_3036092_+|hypothetical-protein
MTHYADLSPYAYPAGSVPEGIEAVNAGWLEPGEEFPRGTVPEEFVRSLALLCRDDPQMQMRGWHRCALPHLDGKDEYPVVIQVGEDRISLGSAEVRVVGRDGRWLIAPNLVHHYVTAHSYLPPEEFIDAVTAHRTTAPMA
>NC_016582.1|WP_043486373.1|3036142_3037741_-|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MSRPADRVNRLTRAWIWPLVIGLAATLSWSSPAGADTSRADLGTALDTLLADPLLKGGAAGVVVADADSGAVLYQHHPDDRLMPASNTKLFTSAAAMGLLGPDYTYRTDVLTDGSRQGRVLRGDLYLRGTGDPTMLAADYERLAAQLAESGITRVTGRLIADDTRFDTQRAGRSWAADDESSYYAAQISPLTLAPDTDYDAGSIIVETAPGAAPGEKPKVTLTPKTDYLRIDNRATTAATGSGSTLSVERQHGSNTITVSGALPAGSSPAKEWVSVWEPTGYATSVFADALARHGVHVTGATRLGRATPPDARSLASHESMPLKKLLIPFMKLSNNIHAEVLAKTIGYETAGRGTWSAGLDAVSDWLKKRGVDTGSVRQVDGSGLSRMDNIAAGRLTELLLSVRDEPWYADWYASLPVACDPDRFVGGTLRSRMCGTPAARNARGKTGSLTGASALSGYVTDADGRELAYSVVLNNFLAPSVKSLEDAIVVTLAKSGADRATAVRPSAVPNATAERAGAADLECSWVKPRRC
>NC_016582.1|WP_014174827.1|3038050_3039532_-|SagB-family-peptide-dehydrogenase
MSPLLLSLYPGTALHDHQGLLTVRHRWGRTPLGPHTPPLAEALHTLAAGPTAIDEMADRINARAESCGLPPEPQLALFHHCLDRLGHTLQRHATHGSRPLATAVPLAPEAAPRPGPVPDTPLTLDRAAHLRPVDGQLALESPRSRFRVRVEDPRTATPLALLARPASRAELGRHCHELPEGALTALLTLLHSTGFLHPVGDAGRDAGRADTADLPSGWSFHELLAYDGARAGPRDRLYGPVFPLRDTEPPPPPVPRPATGRTIPLRRPDLDRAAREDRTFTDVLESRASRRTYGERPLTRDQLGELLYRAARVRTVLAARPEDDRPYAVTSRPYPSAGSAYELELYAAVHRCQGLDRGLYHYNPLGHALTALPGAPGAVDGLLREASAATGAAPPPDVHLTLVSRIKRLSWKYAAHSYALTLKNTGVLLQTLSLVATAMGLSGCAVGGGDSETPVRAFGLAAHTEIPVGAFLLGSAAADGPNYATPPASTRRR
>NC_016582.1|WP_014174828.1|3039528_3040575_-|lantibiotic-biosynthesis-protein
MSRPSDPPTPPGQWVAVHLFHQGDLDTLLLDAVAPALTGLAQAGRIHGHFFLRYWEGGPHLRVRVLSGEPAHPVHNGSQDIATELVDRWNAWLKEHPSPRSVDEAAYLRFATEAAAREGLPGYEPWRGLHDEAEVRGYLPEHDRYGTGAPLAAVERHFMEASRCAEAVLARRPGPAERLSAGFAVSLLTWAVVEPDPQRRLDALRAGAEAWRRMLGPAYDTEAFDRAYESGRGALVRRAGHLLAPAPRPRSDGPTGPIAAWRHSVSRLHASLEALERKGEFTPDLGALRDDPSLLDLPSPRAALTANRCAHLMCNRLGLYGPQEALLRHFAARAAADLHTAGSGAHRP
>NC_016582.1|WP_014174829.1|3040558_3043126_-|lantibiotic-dehydratase
MNTPPDPVVRVAGVPRSTLAVLNTPKSFELAEHILQTREQVAEEGRRIADALHLVIGALPEPALRPRVIGLRRAVHQGRSPRAAEWNTDVRAALPGPLVGRIRGWLDRRAQCGEHTESLAAVLQEETHDSLAALREDLAHPRFRQGLLHATPELDDVLERWIAAPGHPTPGTKALVSLARYLSRAAVKTSPQGTFTATGQGRWTAHGPWLHTGDLERRTTTAELNLARLRRIADGLLRAHPALRDTLRLRLNPALNVADGTLRLIAPGPGARVTAFPAVDRTPRLLDTLSNLDGATVAEAGPGVRRFVAAGILQEDLPLDDLEPCHLDALITWLTGNGLTDNGPTDNGPSALQGTLDALAALRSALPRRPRPADHAERRDQARAARDRLLAVEGALGLPAPGEPYERRPVHEDSVLDGTAVTLGHGPWRPLLADLASVGRALAVLDRDLPARYAVAAWLAERHGPHPHVPLLLVLHELREDPSPTAEHVRALLRPGFGVDDTFLRDSPLPVLRRLTDHRATVLQALRAGELATDVAAPRPPLSLAHYIQPLPGPDGRPRAVLNAVTVGHSHWQGRLDRMRARATDGPVPPSPAPDTRTGRGRIPVDIGGLYASNTNLRHPTLPHAFDHPFTRGARSGPGRIPLGEVTVRLDRATGLPALRSPRCDADLVPVHLGLMSPLLLPPPLATLLRLFGDPHTLFRTGHPLLPGPFADDVPDRGVVSLDRIEAGRVVLRRRSWLTRAGSVPRRTPGERDHEHFLRLLAWRRELGLPASCFVRTRAPGSHGADAFADKGYKPAYIDFASPLLTTAFTRSLGSPDTVVHIEEALPDPAAPDGDTPYTSEFVIELPGDFHEPAV
>NC_016582.1|WP_014174830.1|3043122_3044139_-|hypothetical-protein
MTGHHPGAVQLPPPPALGTVDHALWAARRCTCHTGTPRPAPLPRWAAVLGHACGVGPFEARPDERPGLRGHLGETRVTAGANTPITPGSYAYEPVAHQLVPMRMDHARTYDGALALHLDDDTGETTACVRLVAAACGLCTHTAGPDTLLLYASSTTTPTAGDMEDALAALPVEPPVYTAALGRLTASDLLTLLHKAAPDPPYRVTVRSVDGMDAGVYRADAAQGPLEPVWHGPTAPYAHVLTRGGHPDAAALAGAAAIVHLVGGHGTPRAADALRVRVAASAAGLAAWCDDAPTPAATTLLGLIPGVADVTCHITIGRAWPEPRLRIPVRLATSGALP
>NC_016582.1|WP_043486376.1|3044135_3046028_-|TOMM-precursor-leader-peptide-binding-protein
MRPTELRAAVVGDGGLLNQAIAERLTSERLASGRDLRTHAVLLTVSDGWESDAAHDRHRRRALASGVPWLPVWTEGARALIGPLVRPDAPGCHRCLRMRRAHAREDWPVVRAVRERYATEPEPERSPLLTTVAAEITAHLVAARLMAAAIPSRELTVIGLRTLDVSSHTFLPDPCCPECGGLPDDSPQAAPRTLRPRPKPRPGHRLRRPDATRLRAALADPETGLLREVSAVSAGVPLARAPLTLPGGGEFEAGLGTGDEWGAAQAAALLEGVERYASVRPRARRAAVRAAYAEVREDAVDPRTLGLHPDGHYDLPGFPFRRFDEAAVTEWVWGWSYGRDRPLLLPQSYVYFLSATERDRAFAFEVSNGCALGSCLEEAQLHGLLEVAERDAFFTTWYRRTPLDAIDPDSARDRTVPLLAEHLTQLTGHRVHLLDATQEQHIPCVVALAVDEDERPDTPRAAVAAGAHPDPEQAAVRALMELVPHLTLLTSRYRAERERARQLALDPSLIAHPADHALAAAAPEAFVRLAFLRGGKPPRTFTEVHRGRHLPRYHGDLTDDLRDLIRRYLETGLDVIAVDQTPAEVSALDLAAAKVVVPGTAAVTYGPLMRRTEGLPRLTGHLSADPHPFP
>NC_016582.1|WP_014174832.1|3046014_3047925_-|hypothetical-protein
MGGRRLKLVRQVRYAPTENGAAVLGPSGALALRGAGVYAWLERLWPLLDGAQDVDAVLAQLPDGHRAVATRLLETLQRRDFLREATEPRPHGLTVTELHRHRHEIAYIGHWLDSPEHRFERYRTARVLLLGDGPLYAATRHALLACGLRQVQVLTEDASAPYDTLRAAARTADAVVFTRDATTPQAGPGVAAVERACGGVPLFRALSRPADCWLLPPTAPLTWADVRHRIRHTAAPDSAGPIPMTAAAAALVGGRLALAVFRLLTGVPDEDTDVDADAPGPVPGILRVDLTTLAAHRHRVLPAPRRHDSACAEGRMKELREAPALDPDELTARLADCADDIAGPYAPPTMEYGSQIPLTVAQCVVAGAGVVVGASLDPRAAKAVALRRAGASYALSAAGYVPPQPSDQAAPDPARFRAERLTDGGVRSLPASLVLPCPAGEGQQGGRPVGAGTACAESWDAAVEAALFAAVRSLARQRAADLPSATLMPEGLLTEPEAVRHWRLLCTLGPVPEARDLSGGLVAPVIGLVAGDRLASVGCAATAAGALAEAARELLLARQRGTEPAAGALPLPTASGPPTSHVPASLPGSLPQERIAHLGTSLAAEGYTAYAVPLDHDADFHALVPFIARVVLDEAH
>NC_016582.1|WP_014174833.1|3047994_3048147_-|hypothetical-protein
MENTSLLDLEQLGDEMFEVVESDTTEDKGGAGSAWAYACCHSASSSCALS
>NC_016582.1|WP_043489503.1|3048326_3049514_+|YcaO-like-family-protein
MKKVHFDGTHRVRHPEETWTLINGLRDRFGITRVADVTGLDTLGVPVVMAVRPAAKTLTVSQGKGASLLLARVSAVMESVELWHAEYACPAPELKHTPACELELPYDVCDLQQHHGSLLSERTPLDWVIGVDAVSGTKTLVPRAYVRVDYQVSRAWQPPLLHGSTNGLAGGNTYDEALAHALYEVIERDCTATIGSLPVAERRHVDPSSVDDPLCATVLGRIADAGAWVEIVEVPNRWGLPCFVSYIWSEDFPALAVGSGVHGSPAVALSRALTESAQSRLTAIAGSRDDLAAVLFAGGPSAAGPPPVTEGEFVPWQDVSGRGREFAEDTEETRWLAGEVHRVTGRPPVAVDLSTESGFSVVKVVAAGLEFDGRHEIPRPLTAASSSATNPKGGS

Crispr_ID: NC_016582_5

• CRISPR_ID: NC_016582_5
• CRISPR_location: 3312196-3312280
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_5

Consensus_repeat	Method
CTCATGGCGCAAGTCCAGCCACAGC	CRISPRCasFinder

spacers of NC_016582_5

>5.1|3312221|35|NC_016582|CRISPRCasFinder
AGCGGCGACGGGGACAGCTGCGTCGAAGTCGCCGC

CRISPR arrays and Neighbor proteins around NC_016582_5

CRISPR arrays

The CRISPR arrays of NC_016582_5

>merge|NC_016582|5|3312196-3312280|CRISPRCasFinder
CTCATGGCGCAAGTCCAGCCACAGCAGCGGCGACGGGGACAGCTGCGTCGAAGTCGCCGCCTCATGGCGCAAGTCCAGCTACAGC

>NC_016582|5|4|3312196-3312280|CRISPRCasFinder
CTCATGGCGCAAGTCCAGCCACAGC	AGCGGCGACGGGGACAGCTGCGTCGAAGTCGCCGC
CTCATGGCGCAAGTCCAGCTACAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014175076.1|3316369_3317404_+|bile-acid:sodium-symporter-family-protein	unknown	unknown	gnl|CDD|223462
NC_016582.1|WP_014175074.1|3315260_3315629_-|DUF488-family-protein	unknown	unknown	gnl|CDD|225730
NC_016582.1|WP_055413890.1|3312632_3313961_+|ferredoxin-reductase-family-protein	unknown	unknown	gnl|CDD|99795
NC_016582.1|WP_014175059.1|3302386_3303538_-|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl|CDD|176544
NC_016582.1|WP_014175066.1|3310394_3310589_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_106436568.1|3317413_3319099_-|adenine-deaminase	unknown	unknown	gnl|CDD|223933
NC_016582.1|WP_014175062.1|3305497_3306304_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_016582.1|WP_014175067.1|3310691_3311126_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_016582.1|WP_014175060.1|3303815_3304487_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|153251
NC_016582.1|WP_014175072.1|3313974_3314469_+|FMN-binding-protein	unknown	unknown	gnl|CDD|226484
NC_016582.1|WP_078610374.1|3320132_3321194_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270307
NC_016582.1|WP_043486434.1|3319155_3320136_-|nucleoside-hydrolase	unknown	unknown	gnl|CDD|239117
NC_016582.1|WP_043489576.1|3314510_3315248_+|FAD:protein-FMN-transferase	unknown	unknown	gnl|CDD|376782
NC_016582.1|WP_014175065.1|3309053_3310253_-|argininosuccinate-synthase	unknown	unknown	gnl|CDD|234785
NC_016582.1|WP_014175063.1|3306408_3307383_-|aldo/keto-reductase	unknown	unknown	gnl|CDD|381324
NC_016582.1|WP_106436341.1|3321181_3322243_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|226361
NC_016582.1|WP_014175061.1|3304524_3305349_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|369778
NC_016582.1|WP_014175075.1|3315681_3316275_+|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl|CDD|334450
NC_016582.1|WP_014175068.1|3311291_3312122_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|379262
NC_016582.1|WP_014175064.1|3307486_3308917_-|argininosuccinate-lyase	unknown	unknown	gnl|CDD|179143

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014175076.1|3316369_3317404_+|bile-acid:sodium-symporter-family-protein	gnl|CDD|223462	COG0385, COG0385, Predicted Na+-dependent transporter [General function prediction only].	9.33781e-88
NC_016582.1|WP_014175074.1|3315260_3315629_-|DUF488-family-protein	gnl|CDD|225730	COG3189, COG3189, Uncharacterized conserved protein [Function unknown].	6.01587e-42
NC_016582.1|WP_055413890.1|3312632_3313961_+|ferredoxin-reductase-family-protein	gnl|CDD|99795	cd06198, FNR_like_3, NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P) binding domain. The N-terminal domain may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Ferredoxin is reduced in the final stage of photosystem I. The flavoprotein Ferredoxin-NADP+ reductase transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) which then transfers a hydride ion to convert NADP+ to NADPH.	2.43937e-64
NC_016582.1|WP_014175059.1|3302386_3303538_-|glycerophosphodiester-phosphodiesterase	gnl|CDD|176544	cd08602, GDPD_ScGlpQ1_like, Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of putative bacterial and eukaryotic glycerophosphodiester phosphodiesterases (GP-GDE, EC 3.1.4.46) similar to Escherichia coli periplasmic phosphodiesterase GlpQ, as well as plant glycerophosphodiester phosphodiesterases (GP-PDEs), all of which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. The prototypes of this family include putative secreted phosphodiesterase encoded by gene glpQ1 (SCO1565) from the pho regulon in Streptomyces coelicolor genome, and in plants, two distinct Arabidopsis thaliana genes, AT5G08030 and AT1G74210, coding putative GP-PDEs from the cell walls and vacuoles, respectively.	9.69516e-160
NC_016582.1|WP_106436568.1|3317413_3319099_-|adenine-deaminase	gnl|CDD|223933	COG1001, AdeC, Adenine deaminase [Nucleotide transport and metabolism].	3.95267e-175
NC_016582.1|WP_014175062.1|3305497_3306304_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.55338e-27
NC_016582.1|WP_014175067.1|3310691_3311126_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	1.40027e-17
NC_016582.1|WP_014175060.1|3303815_3304487_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	2.43391e-51
NC_016582.1|WP_014175072.1|3313974_3314469_+|FMN-binding-protein	gnl|CDD|226484	COG3976, COG3976, Uncharacterized protein conserved in bacteria [Function unknown].	1.59521e-10
NC_016582.1|WP_078610374.1|3320132_3321194_-|ABC-transporter-substrate-binding-protein	gnl|CDD|270307	cd13589, PBP2_polyamine_RpCGA009, The periplasmic-binding component of an uncharacterized ABC transport system from Rhodopseudomonas palustris CGA009 and related proteins; contains the type 2 periplasmic-binding fold. This group represents the periplasmic binding domain that serves as the primary high-affinity receptor of an uncharacterized ABC-type polyamine transporter from Rhodopseudomonas palustris Cga009 and related proteins from other bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, and plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	9.56379e-88
NC_016582.1|WP_043486434.1|3319155_3320136_-|nucleoside-hydrolase	gnl|CDD|239117	cd02651, nuc_hydro_IU_UC_XIUA, nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains proteins similar to nucleoside hydrolases which hydrolyze both pyrimidine and purine ribonucleosides: the inosine-uridine preferring nucleoside hydrolase from Crithidia fasciculata, the inosine-uridine-xanthosine preferring nucleoside hydrolase RihC from Escherichia coli and the xanthosine-inosine-uridine-adenosine-preferring nucleoside hydrolase RihC from Salmonella enterica serovar Typhimurium. This group also contains proteins similar to the pyrimidine-specific uridine-cytidine preferring nucleoside hydrolases URH1 from Saccharomyces cerevisiae, E. coli RihA and E. coli RihB. E. coli RihA is equally efficient with uridine and cytidine, E. coli RihB prefers cytidine over uridine. S. cerevisiae URH1 prefers uridine over cytidine. .	1.70732e-103
NC_016582.1|WP_043489576.1|3314510_3315248_+|FAD:protein-FMN-transferase	gnl|CDD|376782	pfam02424, ApbE, ApbE family. This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis. It acts as an FAD:protein FMN-transferase, catalyzing the attachment of an FMN residue to a threonine residue of a protein via a phosphoester bond in such bacterial flavoproteins.	1.30394e-58
NC_016582.1|WP_014175065.1|3309053_3310253_-|argininosuccinate-synthase	gnl|CDD|234785	PRK00509, PRK00509, argininosuccinate synthase; Provisional.	0
NC_016582.1|WP_014175063.1|3306408_3307383_-|aldo/keto-reductase	gnl|CDD|381324	cd19098, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	2.37625e-150
NC_016582.1|WP_106436341.1|3321181_3322243_-|ABC-transporter-ATP-binding-protein	gnl|CDD|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	2.11251e-140
NC_016582.1|WP_014175061.1|3304524_3305349_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|369778	pfam08242, Methyltransf_12, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	2.47287e-14
NC_016582.1|WP_014175075.1|3315681_3316275_+|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl|CDD|334450	pfam01243, Putative_PNPOx, Pyridoxamine 5'-phosphate oxidase. Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as yeast YLR456W and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.	1.77341e-09
NC_016582.1|WP_014175068.1|3311291_3312122_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	5.19592e-09
NC_016582.1|WP_014175064.1|3307486_3308917_-|argininosuccinate-lyase	gnl|CDD|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0

Protein sequences

>NC_016582.1|WP_014175068.1|3311291_3312122_+|helix-turn-helix-transcriptional-regulator
MAGSAGNNEPESSDSLKAFGAIVKVFRERAGLTQEELAPLLQYSVQTLASIEQGRRFPQTEFVERAEDVLDALGVLRAAARHLARRPGLAAWFRQWAGLEEQAVTLCTYECRVVPGLLQTEAYARAVTLSVPPPPDEEQVEQRVTARLARQQLLRRKPPIAFSFIIEEALLERHTGGVEVTKELIDHLLNCTDLWNVELQVIPLHQPRHAGLDGPMRLLETTDHQWLAYSEGQQFGQLISDRKDVSMLLQRYAKMRSQALTPEDSVSLMKRIRGAL
>NC_016582.1|WP_014175067.1|3310691_3311126_-|ATP-binding-protein
MSAQAQTQTPGAVFTQRFSSTLKGARLARLLALRQLDEWGFPCWSAESDTVAAIVAELAANAATHGRVPGRDFEVRLIRTAHTIRIEVADTLSEAGPPTDPAPVAPPPDSETGRGLLLVAAIAARWGVTDRLGPGKAVWAETDT
>NC_016582.1|WP_014175066.1|3310394_3310589_+|hypothetical-protein
MSAQDDILWQTAEHAGHRVASPLEALSSGTVAIGDWLNQDPRRFFATWINDRNKPLLREADGQR
>NC_016582.1|WP_014175065.1|3309053_3310253_-|argininosuccinate-synthase
MTERVVLAYSGGLDTSVAIGWIAEETGAEVIAVAVDVGQGGEDLDVIRKRALACGAVEAEVADAKDEFAEEYCLPAIKANALYMDRYPLVSALSRPTIVKHLVAAAKKHGATTVAHGCTGKGNDQVRFEAGISSLAPGLKCIAPVRDYAMTRDAAIAFCEAKQLPIATTKKSPYSIDQNVFGRAVETGFLEDIWNAPIEDVYEYTSNPATPREADEVIITFDKGVPVAIDGRPVTVLQAIQQLNERAGAQGVGRIDMVEDRLVGIKSREVYEAPGAIALITAHQELENVTVERELARYKRQVEQRWSELVYDGLWFSPLKRALDGFIAEANEHVSGDIRMTLHGGRAVVTGRRSDKSLYDFNLATYDTGDTFDQSLSKGFIEIFGLSSKIAAGRDLEQS
>NC_016582.1|WP_014175064.1|3307486_3308917_-|argininosuccinate-lyase
MSNGNNGDVRLWGGRFADGPSEALEKLSASVHFDWRLAPYDIAGSRAHARVLRAAGLLTEDELERMLAGLDLLEADVASGEFTGTIADEDVHTALERGLLERLGPDLGGKLRAGRSRNDQVATLFRMYLRDHARIIGGLIADLQGALVGLAEAHPDVAMPGRTHLQHAQPVLFAHHVLAHAQALSRDAERLRQWDTRTAVSPYGAGALAGSSLGLDPQAVAADLGFEGGSSANSIDGTASRDFVAEFAFITAMIGIDLSRIAEEIIIWNTKEFSFVTLHDAFSTGSSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKALPLAYNRDLQEDKEPVFDSCDQLEVLLPAFTGMMATLTVNRERMEELAPAGFSLATDIAEWLVKQGVPFRVAHETAGECVKECERTGIELDQLTDEQFAKISPHLTPEVRTVLNVPGALASRNGRGGTAPSAVAAQLVEVKADLAAQREWADAKR
>NC_016582.1|WP_014175063.1|3306408_3307383_-|aldo/keto-reductase
MAFARLAEVTTPTARIGLGLAAVGRPGYINLGRERDLPAERTVEAMRERTYEVLDAAYARGVRYLDAARSYGRAEEFLAGWLDRRPEVRDVVVGSKWGYTYVADWRTDVKTHEVKDHGVATYDRQSAESRALLGDRLDLYQVHSVTLGSPALTDPELHARLARLAAEGVTIGLSTSGPAQADAIRAALEVTVDGEPLFRTVQSTYNLLDPSAGAALAEAHEAGRAVIIKEAVANGRLAAPDQLPEALRRIAQETGAGPDAVALAAVLHQPWVSVVLSGAATTAQLASNLAAAQLTLDEGQRESLGALAEPPEDYWHHRAQLPWA
>NC_016582.1|WP_014175062.1|3305497_3306304_+|alpha/beta-hydrolase
MITPVPGFIPLRGRRVACLDFGGPGAPVLALHGHFGRGRLYAPLAAALAPGHRVIAPDLRGHGLTGGGGPFSLDEYAADAAALLRALRLGPVPVVAHSTGGVIAYALAARHPELVSALVIEDIGAVTDRPVADHPVLDVSGWPTGAADREALRHEIESRGIPDATYFLDSAEPDPGGGGWRLLFSPRELMESQRAMCGDFWAHWLGSDCPSLLLRGEHSPMLPAAHAHEMTARRAGTALREFAGCGHWIHDDAPEAYAGAVREFLTGR
>NC_016582.1|WP_014175061.1|3304524_3305349_-|class-I-SAM-dependent-methyltransferase
MPIRTASAASTAEPGTKNRASALHKVRYAVRHPQRVPRYVRRLARDLRLRVSTRDHIAYYRAVMRDDTARNPEAAVGSASHERWLALGEMQYDYLLRHGLRPDDRLLDIGCGNLRAGWRFIDYLDAGHYHGIDISPDILLAAQEVVAGRGLQAKLPLLSLVRDLRLAALPEAHFTVVHAHSVFSHSPREVIDECLAHVGRVLAPGGYFDFTFNRTEGSEHHVLREDFYYRTANLVRLAADHGLAARFMDDWEELPHRQSKIRVTHGDVHSDEAA
>NC_016582.1|WP_014175060.1|3303815_3304487_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MSRFVFLKAVLGPLMRLMFRPQVEGAERIPGSGPVILAGNHLTFIDSMILPLVCDRQVVFIGKDEYVTGKGLKGRLMAWFFTGVGMIPVDRDGGHGGVAALMTGRRVLEEGRMFGIYPEGTRSPDGRLYRGRTGIARLTLMTGAPVVPFAMIGTDRLQPGGKGLPRPGRVTVRFGEPLEFTRYEGMDRDRFVLRAVTDEVMSEVMRLSGQEYVDMYATKAKAA
>NC_016582.1|WP_014175059.1|3302386_3303538_-|glycerophosphodiester-phosphodiesterase
MEREQKPGRRAILGAAALGAGAMALGGAGTATAAEASGEASGKGHGLPVPTVIGHRGASGYRPEHTMGSYQLALDLGADIIEQDLVPTKDGHLVCRHENDITATTDVSAHPEFADRKTTKTVDGTALTGWFTEDFTLAELKTLRAKERIPGNRQRNTLYDGRWEVPTFEEVLQWAEREGRKRGRRVWLYVETKHPTYFRKLGLGLEEPLAKLLRRYGRHKKDAALFLQSFEPSSIQRLRKLVDTPAVVLLSTINSRPWDFIEANDPRTVADLVKPEGLKWIAGYAQGIGPDLSVIIPRTADGKLGTPTSVVKDAHAAGLVLHPYTMRNENTFLPADFRRGTDPNAYGDAFGAFKKYFETGIDGIFSDNPDTALLAAEDFRKSR
>NC_016582.1|WP_055413890.1|3312632_3313961_+|ferredoxin-reductase-family-protein
MRRIRPRRSPAVPLILLSWTGAAAVVTLWWQNTPNVVGNAEWLVGGGRLTGLLSGYSIALVVLLMARVPALERRVGSDRVARWHAMSGRYTLCLILAHIALIIWGYSAQAQTSVVDQTVTVVTEYPDMIKAVVGTGLLLLIGLISAGVVRRRMPYEAWYYLHLLTYAGVFLAFWHQLTAGAEFVADEMARIGWYALYGSVTAAMVWYRVLVPVGLNLRHRMRVLAVVPEAPGMVSVVIGGRNLDRLGAEPGQFFRWRFLAPGLRWGSHPYSLSAPPQEERLRITVKAVGGHSTALATLEPGTRVWAEGPYGAMTTGRRSRSKVLMIAGGAGITPLRALFETLPGRGSDITLLYRARSMEDLALWDELQRIAEERGARLLYAVNGPDGARPEITPERLRSVLPDIDRHDVFLCGPPGLTEHAYAALREAGVPDRRIHHESFEM
>NC_016582.1|WP_014175072.1|3313974_3314469_+|FMN-binding-protein
MKRKHPLRRIMLGTAATVSGVVLLLALKQPGSEPVAAAGPQNPAQAPQAPATAPAAPGGGNGGGGGGGGNGGGARTVTGDAAQTQYGPVQVSVTVNGGKITGATAVKTPDSGPQSEQIAADSVPKLNQAALTAQSAKIDTVSGATYTSEGYRKSLQSALDKAGL
>NC_016582.1|WP_043489576.1|3314510_3315248_+|FAD:protein-FMN-transferase
MGTVFSLDVREVPEADRPRVRAALDGAAAWLHRVDELFSTWRADSQISRLHRGELDVSQCDADVRDVLRLAEEADRLSDGWFSVRYAGQLDPTGLVKGWAVERAAQMLASAGAGSVCVNGGGDIQTHGGPWRVGIADPLCAGELAAVVETRDELAVATSGPAERGCHILDPYTGAPPADPLASVTVVCRSLTDADAWATAACAMGAERARPWLQRLPGAAAFAVTSDGTTWQTSGFARYDAAMYV
>NC_016582.1|WP_014175074.1|3315260_3315629_-|DUF488-family-protein
MRDSSGNGIRIRRVYETPDPDDGTRVLVDRIWPRGLAKDAARLDEWLKAAAPSTELRRWYGHAPERSAEFGRRYRAELADPERRAAVDHLRELAATGPLTLLTATKDPAQSHLPLLAEAVGS
>NC_016582.1|WP_014175075.1|3315681_3316275_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MGKVYERIDGRLRTFIEEQKIFFTATAPLAGDGTVNLSPKGLTGSFAVLDELTVAYLDFAGSNAETIAHLRENGRITLMWCAFTGPPNIVRVHGRGEPVFRDDPRFPGLLEHFPDIDVAEHGLRAIIVVTAELIRDTCGFAVPFMDYREDRTLHADRFRRENDDTLSAYFEKKEHVASSIDGLPGLPLPLPLPPRTA
>NC_016582.1|WP_014175076.1|3316369_3317404_+|bile-acid:sodium-symporter-family-protein
MRGAPPRAFDHAVRSEDTSRRADATAPPTPPQPATADRAARRAVTVFPLLVLAAGAAGLATPGTFSGWAPNVPYLLGTIMFCMGLTMTTQDFSGVVKRPWAVALGLVAHYVIMPGLGWLIAHALGLSPQLAAGVILVGCAPSGTASNVVTYLARGDVALSVSVATVSTVLAPLVTPPLTLLLAGEYLPVDAGSMVTDILKTVLLPVVGGVVVRLLAGRYLARVLGLLPWLSAATIAVIVAVVVAASADAIKSAAGLVLLAVVLHNGLGLALGYAAGRAARLGEPAGRAMAFEVGMQNSGLAASLASAHFSPLAALPAAVFSVWHNISGALVAAWMSHRSRRAEG
>NC_016582.1|WP_106436568.1|3317413_3319099_-|adenine-deaminase
MPSRCDLLIRGAGVFSVHTGEILPADVVVTGDLIRAVAAPGVRIEAERVLDADGLIVAPGYIDAHMHIESSLLTPAEFARITLPRGTTTVLADPHEIVNVAGRDAMAWMIEQGRGAAQTMLWAVPSCVPALEGFETAGSSLTAEDIAEMLDWDGVTTLGEVMDYRAVVAGSPRMRSIVDAARRKGVRLDGHCPNLTGDDLGEYLWAGIDSDHTKNTPEVAVEKARLGMLLMLQEKCLSAELVRRLHELPVLPDFCLVTDDLAADAILDRGHLDHIARVALDAGMSPATVLRALTLHPARRLGLDDRGVVAPGKRADLVLLRALDDPTPVTVVCGGRVVAGDDTAGPTPDNPFADSVRLAPLEEADCVWRADLPDGEHTFRALRVNPVDTFTEPAEVVLPVRDGVVHWEGRTAVLAVYERHHGTGRRTMAPVVGFDLAEGATATTYAHDSHNLTVVATDAGALRRAANRVIGSGGGICVAVTGRPDVHLPLPVGGVMSTAPAPEVAAGAGAVREALHGWGWLHRNAFMSVSTMTLPVSPQIKLTDLGLVRVVDRAWEDPVVA
>NC_016582.1|WP_043486434.1|3319155_3320136_-|nucleoside-hydrolase
MSQAPRRVVIDCDPGIDDAIALFLAYASPELEVAGVTTVAGNVGLDQVVDNALRLCDLIGGPAAATPVLRGHAGPLARVPRHPDEPVHGAYGLGGVELPAAARAAHPGHAVDWIAEQLRGAGPGEITLIATAPLTNVAALLHTHPDTRRLLREIVVMGGAAFAPGNTTPAAEFNFHADPEAARYVTESGVPLHIVGLDVTRKALTPLADADALVADGAPVTTAAGQMLRHLIDRYARRHQVRACAVHDALAVAAAVRPELLEWTEAWVTVECAGEFTRGALVADVHGRTGLAPNARVATGVDAEAFRAFLMSRLRGHYGADTTPAP
>NC_016582.1|WP_078610374.1|3320132_3321194_-|ABC-transporter-substrate-binding-protein
MSRMIRTARLTTGALAASLIAFTLSGCAESAKADPKKLTVSTFGFGADRFEETVIKPFEKKTGIDVTLETGANADRLTKLRVNKNDPTVDVVMISDLFAAMGQKQGLFDKVDAKKVPNMAKIYDFAKSQDGYGPAYTYQLLGMLYRTDKVKQPPTLETLWDAKYKGKVAVPDLSTSAGVPFLQAVSATYGSGPKDTDTGFKKLSDLKPNVLKFFNRSTELVSLLDRGEVEMAPGLDLFAVDPAKAGKPIGWVPFDKGRYVAANTAQIVKGAKNKAGAEKFLDYLLSADVQEKAAASFSDKPVNKDAKVPAAITKVSGEAASDPAAAGFTSPDLKYSVEHNDAWVDRFQREVSG
>NC_016582.1|WP_106436341.1|3321181_3322243_-|ABC-transporter-ATP-binding-protein
MTSTMTTTKTTTPVVQLQAITREFAGSVAVDSIDLTVRRGEFTALLGPSGCGKTTTLRMIAGFLPPTSGTILLDGQDATTLPPERRNIGMVFQSYALFPHLTVEKNVAFGLRMRGVPSAEIRTRVAEVLDLVGLAHLAGRKPKELSGGQQQRVALARAVAIRPSVLLLDEPLSNLDARLRVQMRQELLRVQRETGLTAILVTHDQEEALELADNMVILDRGRIVQQGPPREVFRAPATRFVAEFLGYENFLDLPGRGPVTIRPEHIGVLGPDAEPPAGGEVVEATVTAVRFRGTDFAVTAAVGDRTLHAITTDETLRAGASVRLHLPLGQAIPLPGDDGAARLGKNPRQECPA

Crispr_ID: NC_016582_6

• CRISPR_ID: NC_016582_6
• CRISPR_location: 3787655-3787728
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_6

Consensus_repeat	Method
GCGAACCGCGCCCCACGCGGCCG	CRISPRCasFinder

spacers of NC_016582_6

>6.1|3787678|28|NC_016582|CRISPRCasFinder
CGCCACGGGTGCGGCCTCCTCCGCCCCG

CRISPR arrays and Neighbor proteins around NC_016582_6

CRISPR arrays

The CRISPR arrays of NC_016582_6

>merge|NC_016582|6|3787655-3787728|CRISPRCasFinder
GCGAACCGCGCCCCACGCGGCCGCGCCACGGGTGCGGCCTCCTCCGCCCCGGCGAACCGCGCCCCGCGCGGCCG

>NC_016582|6|5|3787655-3787728|CRISPRCasFinder
GCGAACCGCGCCCCACGCGGCCG	CGCCACGGGTGCGGCCTCCTCCGCCCCG
GCGAACCGCGCCCCGCGCGGCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_043486528.1|3777345_3777555_+|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl|CDD|378324
NC_016582.1|WP_014175478.1|3777802_3778309_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014175490.1|3793236_3793749_-|FMN-binding-protein	unknown	unknown	gnl|CDD|214897
NC_016582.1|WP_014175479.1|3778385_3779441_+|lipoate--protein-ligase-family-protein	unknown	unknown	gnl|CDD|319742
NC_016582.1|WP_106436587.1|3797728_3799309_+|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl|CDD|334820
NC_016582.1|WP_193383786.1|3795343_3796060_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NC_016582.1|WP_014175481.1|3780330_3781893_-|NCS1-family-nucleobase:cation-symporter-1	unknown	unknown	gnl|CDD|271378
NC_016582.1|WP_014175487.1|3789620_3791432_-|gamma-glutamyltransferase	unknown	unknown	gnl|CDD|223482
NC_016582.1|WP_014175484.1|3784430_3785774_-|aspartate-aminotransferase-family-protein	unknown	unknown	gnl|CDD|99735
NC_016582.1|WP_055414154.1|3793776_3795132_-|ferredoxin-reductase-family-protein	unknown	unknown	gnl|CDD|99795
NC_016582.1|WP_014175483.1|3783021_3784431_-|dihydropyrimidinase	unknown	unknown	gnl|CDD|236240
NC_016582.1|WP_055414153.1|3792455_3793163_-|FAD:protein-FMN-transferase	unknown	unknown	gnl|CDD|376782
NC_016582.1|WP_014175488.1|3791631_3792375_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_043486530.1|3779508_3780267_-|heparin-lyase-I-family-protein	unknown	unknown	gnl|CDD|372911
NC_016582.1|WP_014175495.1|3799319_3800183_-|amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|223836
NC_016582.1|WP_014175476.1|3776296_3777244_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235737
NC_016582.1|WP_014175485.1|3785770_3786613_-|apolipoprotein-acyltransferase	unknown	unknown	gnl|CDD|143592
NC_016582.1|WP_014175482.1|3781988_3782990_-|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl|CDD|163554
NC_016582.1|WP_043489772.1|3796110_3797586_+|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|273593
NC_016582.1|WP_014175496.1|3800179_3800824_-|amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|223836

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_043486528.1|3777345_3777555_+|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl|CDD|378324	pfam09957, VapB_antitoxin, Bacterial antitoxin of type II TA system, VapB. VapB is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is VapC, pfam05016. The family contains several related antitoxins from Cyanobacteria and Actinobacterial families. Antitoxins of this class carry an N-terminal ribbon-helix-helix domain, RHH, that is highly conserved across all type II bacterial antitoxins, which dimerizes with the RHH domain of a second VapB molecule. A hinge section follows the RHH, with an additional pair of flexible alpha helices at the C-terminus. This C-terminus is the Toxin-binding region of the dimer, and so is specific to the cognate toxin, whereas the RHH domain has the specific function of lying across the RNA-binding groove of the toxin dimer and inactivating the active-site - a more general function of all antitoxins.	7.24603e-06
NC_016582.1|WP_014175490.1|3793236_3793749_-|FMN-binding-protein	gnl|CDD|214897	smart00900, FMN_bind, This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins.	6.97048e-11
NC_016582.1|WP_193383786.1|3795343_3796060_+|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.12702e-83
NC_016582.1|WP_014175479.1|3778385_3779441_+|lipoate--protein-ligase-family-protein	gnl|CDD|319742	cd16443, LplA, lipoate-protein ligase. Lipoate-protein ligase A (LplA) catalyzes the formation of an amide linkage between free lipoic acid and a specific lysine residue of the lipoyl domain in lipoate dependent enzymes, similar to the biotinylation reaction mediated by biotinyl protein ligase (BPL). The two step reaction includes activation of exogenously supplied lipoic acid at the expense of ATP to lipoyl-AMP and then transfer to the epsilon-amino group of a specific lysine residue of the lipoyl domain of the target protein.	1.31547e-63
NC_016582.1|WP_014175481.1|3780330_3781893_-|NCS1-family-nucleobase:cation-symporter-1	gnl|CDD|271378	cd11485, SLC-NCS1sbd_YbbW-like, uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. This subfamily includes the putative allantoin transporter Escherichia coli YbbW (also known as GlxB2). NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	0
NC_016582.1|WP_014175487.1|3789620_3791432_-|gamma-glutamyltransferase	gnl|CDD|223482	COG0405, Ggt, Gamma-glutamyltransferase [Amino acid transport and metabolism].	0
NC_016582.1|WP_014175484.1|3784430_3785774_-|aspartate-aminotransferase-family-protein	gnl|CDD|99735	cd00610, OAT_like, Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, alanine-glyoxylate aminotransferase, dialkylglycine decarboxylase, 4-aminobutyrate aminotransferase, beta-alanine-pyruvate aminotransferase, adenosylmethionine-8-amino-7-oxononanoate aminotransferase, and glutamate-1-semialdehyde 2,1-aminomutase. All the enzymes belonging to this family act on basic amino acids and their derivatives are involved in transamination or decarboxylation.	6.83262e-135
NC_016582.1|WP_055414154.1|3793776_3795132_-|ferredoxin-reductase-family-protein	gnl|CDD|99795	cd06198, FNR_like_3, NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P) binding domain. The N-terminal domain may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Ferredoxin is reduced in the final stage of photosystem I. The flavoprotein Ferredoxin-NADP+ reductase transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) which then transfers a hydride ion to convert NADP+ to NADPH.	1.40397e-61
NC_016582.1|WP_014175483.1|3783021_3784431_-|dihydropyrimidinase	gnl|CDD|236240	PRK08323, PRK08323, phenylhydantoinase; Validated.	0
NC_016582.1|WP_055414153.1|3792455_3793163_-|FAD:protein-FMN-transferase	gnl|CDD|376782	pfam02424, ApbE, ApbE family. This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis. It acts as an FAD:protein FMN-transferase, catalyzing the attachment of an FMN residue to a threonine residue of a protein via a phosphoester bond in such bacterial flavoproteins.	2.88073e-50
NC_016582.1|WP_106436587.1|3797728_3799309_+|prolyl-oligopeptidase-family-serine-peptidase	gnl|CDD|334820	pfam02129, Peptidase_S15, X-Pro dipeptidyl-peptidase (S15 family).	4.71194e-36
NC_016582.1|WP_043486530.1|3779508_3780267_-|heparin-lyase-I-family-protein	gnl|CDD|372911	pfam14099, Polysacc_lyase, Polysaccharide lyase. This family includes heparin lyase I, EC:4.2.2.7. Heparin lyase I depolymerizes heparin by cleaving the glycosidic linkage next to an iduronic acid moiety. The structure of heparin lyase I consists of a beta-jelly roll domain with a long, deep substrate-binding groove and an unusual thumb domain containing many basic residues extending from the main body of the enzyme. This family also includes glucuronan lyase, EC:4.2.2.14. The structure glucuronan lyase is a beta-jelly roll.	1.89485e-30
NC_016582.1|WP_014175495.1|3799319_3800183_-|amino-acid-ABC-transporter-permease	gnl|CDD|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	7.84808e-54
NC_016582.1|WP_014175476.1|3776296_3777244_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|235737	PRK06197, PRK06197, short chain dehydrogenase; Provisional.	5.58805e-71
NC_016582.1|WP_014175485.1|3785770_3786613_-|apolipoprotein-acyltransferase	gnl|CDD|143592	cd07568, ML_beta-AS_like, mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases). This family includes mammalian-like beta-AS (EC 3.5.1.6, also known as beta-ureidopropionase or N-carbamoyl-beta-alanine amidohydrolase). This enzyme catalyzes the third and final step in the catabolic pyrimidine catabolic pathway responsible for the degradation of uracil and thymine, the hydrolysis of N-carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyrate to the beta-amino acids, beta-alanine and beta-aminoisobutyrate respectively. This family belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 5. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Beta-ASs from this subgroup are found in various oligomeric states, dimer (human), hexamer (calf liver), decamer (Arabidopsis and Zea mays), and in the case of Drosophila melanogaster beta-AS, as a homooctamer assembled as a left-handed helical turn, with the possibility of higher order oligomers formed by adding dimers at either end. Rat beta-AS changes its oligomeric state (hexamer, trimer, dodecamer) in response to allosteric effectors. Eukaryotic Saccharomyces kluyveri beta-AS belongs to a different superfamily.	6.29481e-153
NC_016582.1|WP_014175482.1|3781988_3782990_-|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	gnl|CDD|163554	TIGR03842, F420_CPS_4043, F420-dependent oxidoreductase, CPS_4043 family. This model represents a family of putative F420-dependent oxidoreductases, fairly closely related to 5,10-methylenetetrahydromethanopterin reductase (mer, TIGR03555), both within the bacterial luciferase-like monoxygenase (LLM) family. A fairly deep split (to about 40 % sequence identity) in the present family separates a strictly Actinobacterial clade from an alpha/beta/gamma-proteobacterial clade, in which the member is often the only apparent F420-dependent LLM family member. The specific function, and whether Actinobacterial and Proteobacterial clades differ in function, are unknown. [Unknown function, Enzymes of unknown specificity].	0
NC_016582.1|WP_043489772.1|3796110_3797586_+|HAMP-domain-containing-protein	gnl|CDD|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	8.8662e-56
NC_016582.1|WP_014175496.1|3800179_3800824_-|amino-acid-ABC-transporter-permease	gnl|CDD|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	3.98945e-55

Protein sequences

>NC_016582.1|WP_014175485.1|3785770_3786613_-|apolipoprotein-acyltransferase
MANVVRAALVQCTWTGDTESMIAKHEEYARQAAAQGAKVIGFQEVFNAPYFCQVQEAEHYRWAEPVPDGPTVRRMRELARETGMVMVVPVYEVEQSGFYYNTAAVIDADGSFLGKYRKHHIPQVKGFWEKYYFKPGNLGWPVFDTAVGKVGVYICYDRHFPEGWRELGLAGAQLVYNPSATSRGLSAYLWQLEQPAAAVANEYFIAAINRVGVEEYGDNDFYGTSYFVDPRGQLVGEAADDKTEELVVRDLDFGLIDEVRQQWAFYRDRRPDAYEGLVKP
>NC_016582.1|WP_014175484.1|3784430_3785774_-|aspartate-aminotransferase-family-protein
MNSELHDRHKAVLPDWIALYYERPIELTHGEGRHVWDADGNRYLDFFGGILTTMTAHALPEVTKAVSEQAARILHSSTLYLDRPMVELAERVAELSGIPDPRVFFTTSGTEANDTALLLATTYRRSNQILAMRNSYHGRSFSTVGITGNRSWSPTSLSPLQTLYVHGGVRGRGPYAGLSDAEFIKACTADLEDVLGQACGQVAALIAEPVQGVGGFTSPPDGLFAAFREVLDRHGILWISDEVQTGWGRTGDNFWGWQAHDASGPPDVLTFAKGIGNGMSIGGVVARAEVMNCLGANSISTFGGSPITMAAGLANLTHLLEHDLQGNARRVGGLLMDRLRTAAAGLDVVREVRGRGLMIGIELVEPGSDRPSPDAASAVLEAAREGGLLLGKGGGHNSSVLRIAPPLSLTAAEAEEGAEILATALRTAQAMADGSAEAADEAGRSTL
>NC_016582.1|WP_014175483.1|3783021_3784431_-|dihydropyrimidinase
MSRSSRTVIRGGLVITAAEETRADVLVEDGRIVALAAPDSAYAQGWTADRTIDATDKYVIPGGVDAHTHIEMPFGGTFASDTFETGTRAAAWGGTTTIVDFAVQSMGHSLREGLDAWHAKAAGMCAIDYSFHMILADVNEASLREMDLLVDEGITSFKLFMAYPGVFYSDDGKILRAMQRGAANGGLMLMHAENGLAIDVLIEQALAEGRTDPRYHGEVRKSLLEAEAAHRAIQLARVAGAPLYVVHVSAAEAVAELAQARDKGLPVFGETCPQYLFLSTDNLAEPDFEGAKYVCSTPLRPREHQAALWHGLRTNDLQIVSTDHCPFCFVGQKEMGRGDFSKIPNGLPGVENRMDLLHQAVVDGHISRRRWIEIACATPARMFGLYPKKGTIAPGTDADLVIYDPRAEQTLSAQTHHMNVDYSAYEGKRITGQVETVLSRGETVIDRRQYTGRAGHGQFIARDTCQYLN
>NC_016582.1|WP_014175482.1|3781988_3782990_-|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase
MDFGLVLQTDPPAAGVVELMRRAEGAGFTHGWTFDSAVLWQEPFVIYSRILEHTERLIVGPMVTNPSTRTWEVTASTFATLNEMYGNRTVCGIGRGDSAMRVAGRKPNTLARLGQAIDAIRDLAEGREAVVDGTPVRIPWVENGRLPVWMAAYGPKALALTGRKADGFILQLADLYLTEWMVKAVRTAAVEAGRDPAALTICVAAPAYVGDDLDHAREQCRWFGGMVGNHVADLVKRYGEHSDAVPEALTAYIKGRAGYDYSHHGRTGHPSTGFVPDEIVDHFCLLGPAEAHIEKLRALRALGVDQFAIYAMHDAKEATIDAYGEHVIPALAD
>NC_016582.1|WP_014175481.1|3780330_3781893_-|NCS1-family-nucleobase:cation-symporter-1
MTASAPPPPPPPPSPAGSAQTTHPDGRVELPVGAAVPTGRYANEDLLPVPVARRTWNTYNFAALWVGMAHNAATWTLASGLIQLGMDWKQAVLTIAVANVIVLVPMLLTGHAGPRYGIPFPVFARASFGIRGANFPALIRAAVACAWFGIQTWIGGAAIFLLVGNMLGDWWTGAASFGGYPWTHWLSFALFWALQIAIIVRGMETLRRFENWAAPFVIVGAVALLIWISNKAGGFGPLLDQPSELGWDGDFWSVFFPALMPMIGFWSTLSLNIPDFTRYGANQRSQFWGQSLGLPTTMTLFTLLSVLVTSGTQAVYGAPIWQPEQVAAKIDNWAGVLFALITILVATVSVNIAANVVSPAFDLSHMAPGKITFRLGAVIAAVVGVAIFPWKLYASPDVYIFTWLDTVGALLGTVAGILIADYWIIRRAFLHLPDLYREGGRYWYSGGWNWRALAAFAAGGVLAIGGAHTDPGTAGPFPEDGLIPFLKPLGDYGWAVGLGTSLVLYTLLMLGRREKTASRA
>NC_016582.1|WP_043486530.1|3779508_3780267_-|heparin-lyase-I-family-protein
MKRRQALTLLGGLGLAGPLTTLTPSGRASAAELPEGVYFQNRGSVEGWDYSYTQKQGSISTIDTPAYKGAHSLEATQTYINETGGYHSEVLQRGAQSVGQDRYYGQAIRLAPDWRFHNQNVTFQQWSPEDPEGPWLLMFVQGEEIRYGGRAVSGTVGKITDLRGTWIRLVVRLKLADDGQGAYEVWLNGRKTVSSTGITLLPSTSQTIRWSNGIYCTAWRDGTPAGASTLTILHDQHRIAASYALAEPANWT
>NC_016582.1|WP_014175479.1|3778385_3779441_+|lipoate--protein-ligase-family-protein
MHGEYKVPGGKLVVVDLEVEDGRLKDVRVAGDFFLEPDEALLAINRALEGAPADTDARGLAGRVEAALPEGTVMFGFTADAVGVAVRRALAHATDWTDYDWQLIHEGPQPPALHMALDEVLTEEVALGRRPPTLRVWEWASPAVIIGSFQSLRNEVDPEGAERHGVEVVRRISGGGAMFVEPGNTITYSLYVPESLVSGLSFADSYAYLDDWVLGALGDMGIAAWYQPLNDIATDAGKIGGAAQKRVVTGAGAVLHHVTMSYDIDADKMVEVLRIGREKLSDKGTRSAKKRVDPLRRQTGLARAAVIDRMIASFRERYGLTDGKVTEEEAARAQRLAEAKFGSWEWTTRVP
>NC_016582.1|WP_014175478.1|3777802_3778309_+|hypothetical-protein
MFDFGIQGYRPHWMRGPRAVRQAHGARLRALIGRSLTRLWVVWDLEDDEWFPDCPVLFDFDGEQVEINHWKLDELSLTWNAVDPRRPVEWPGFALRWRANPLPEAALLLGQPLQNVELLEWTGPDAARGTVDVSFVFPDGRITVHNALDENGLSFTPPHRQSRPHPLG
>NC_016582.1|WP_043486528.1|3777345_3777555_+|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MSRTVIDLDDDTAEELMRLYKVKTKAAAVRRAMEETVKLHRRLEFMDAIDSGAIDLTYDARTTATGDAA
>NC_016582.1|WP_014175476.1|3776296_3777244_+|SDR-family-NAD(P)-dependent-oxidoreductase
MPSTAPIKPWDVHRLPLATGTNILVTGGNAGIGYFVAEQLAGAGATVVLGSRDTAKAETAAVSIRSRVPGAQVRWVRLDLADLFSLKASAEALHLDRLDAVVLNAGVMLDHPPRRETHDSHELMFATNHLGHFALTRQLAPLLAAAPAARIVTTGSFAAKSERLDLDDLQSTRDYQPKRTYARSKLAQMLFGLELDRRLRAAGSTALSVVTHPGGALDSLTPSRPPVHVRTTGDRLRGLPAGLLVQGKEAAAWPAVRAVLDPAVAGGQLWAPRVFGLRGLPRPAPLWDHLTDTAVAARLWDASCELTGVDPSVGL
>NC_016582.1|WP_014175487.1|3789620_3791432_-|gamma-glutamyltransferase
MRRLPALAATAGLVVVLGIAPAGARGGAAGGAAPADTPAKTPVAVGYGGAVSSVDADASAAGIEVLRRGGNAVDAAVATAAALGVTEPYSAGVGGGGYFVYYSAKQHKVFTLDGRETAPRSADDKLFLDKDGKPIPFADVVTSGLSIGTPGTPGTWDTALDTWGTRSLAQVLKPAQRIARDGFTVDATFRQQTADNQARFKDFPDTAKLFLPGGELPVVGSTFTNPDLARTYALLAKKGVGAVYKGELGRDIVKTVRKPPVDPAAQRVVRSGDLTERDLASYKVKRQAPSKTSYRGLDVYGMAPSSSGGTTVAEALNILEKTDLTKLSDRDYLHRYIEASRIAFADRGRWVGDPAFEDVPTKGLTSQRFADSRACLIKADAVLSSPLAPGDPARPTGCDSGGTAAPTTYEGENTTHLTVADKWGNVVAYTLTIEQTGGSGITVPGRGFLLNNELTDFSFAPANPAVHDPNLPGPGKRPRSSMSPTIVTDKGRPVLALGSPGGATIITTVLQTLLGHLDRGMPLVDAIAAPRASQRNAAQTELEPGLWNSPLRGQLTTLGHSFKQNPEIGAATGVQRLSGGRWLAAAETVRRGGGSAMVVSPDK
>NC_016582.1|WP_014175488.1|3791631_3792375_+|hypothetical-protein
MTDTVQDLIASGAALVVGLALGWAVHSAYARRKRAREQAFFGLPDGSECVLVTHRDSTSAHWSIPRHDALALFGIAAVVENCGAHAEVAPHDTGLQGFGARTEFCVGDPTAHRRLAAHMGNLLPGVAVHEGDETQERGSFTIGGTEYRPEPGAVEYVLLARLTAGESGRPVFLAAGQRPVTHRAAIRHLVRNRTRLARKYGAQGSFCLLLKVVNSQAYGPDVVEVVADVTKAATSAPGRSRAAHKSD
>NC_016582.1|WP_055414153.1|3792455_3793163_-|FAD:protein-FMN-transferase
MGTVFSFDIRDPATPAIGRALKEAVAWLHHVDEVFSPYRPDSAISRLGRGELSVERCGPEVAEVLGLCEAAERATDGWFSHTAGGRLDPSGMVKGWAVERASAILYGAGAHNTCVNGGGDIQLRGEAAPGVPWRVGIAHPLLPGALCAVVTGRDLAVATSGTAERGPHVLDPHTGEPATALASLTLTGPGLTWTDALATAAFAMGPAARAWTEALESHQAMGVTATGDLWQTPGF
>NC_016582.1|WP_014175490.1|3793236_3793749_-|FMN-binding-protein
MRKAALTTVSTVAGVVLLLSLKPHTDTPTTAPPAVAAQPPSPSSAPSSSPSSSPSSSPSSSGAAAAPSPSTSHTTSAGPTGTYTGDTINTRYGPVQLAVTLSKGKITAVKALQTPSGDGRSQQIASYAVPQLTNETLQAQNAQIDTVSGATYTSDGYVQSLQSALDQAGV
>NC_016582.1|WP_055414154.1|3793776_3795132_-|ferredoxin-reductase-family-protein
MHDRRADPPRARPLTPGPPGLVPALTQPAIGAGAAAVLALWWRDTTSVVGVAGWLTGAGRITGLLAGYATAVLLLLMARVPVLDRNVGSDRLARWHATGGRYVVSLALAHTLLIIWGYALTSHTGVVDQTTTLVLHYPDLLKGTVGFLLLLATGVLSARAARRRVSYETWHLLHLATYLAIFLAFGHQLSDGADFVGNRTAQLAWYGLYGGVAALLLWFRFLLPVRRALRHRLWVSEVRPEAPGVVSVYLTGDRLDELRAEPGQFFRWRFLAPGLWWAANPYSLSAAAHPSFLRITVKAAGGHSAALARLAPGTRVLAEGPYGAFTARRRRAPKVLLLGGGVGITPLRALFETIPGEVTLIYRARRPEDLALRTELDQLAARRGATVHYVVDEPVEYSSPLTARELRRLVPDLAERDVYLCGPPGMAEAAQRALRGAGVPRRRIHHESFAF
>NC_016582.1|WP_193383786.1|3795343_3796060_+|response-regulator-transcription-factor
MLRPDGTPVRVLVVDDEPDLTEVLSGALRYEGWEVRTAADGASALATARAFGPDAVVLDWMLPDSDGLTVLRGLRAELAGVCVLFLTARDAVEDRIAGITAGGDDYVTKPFSLEEVLARLRGLLRRAGMARGSDLHQADRLVVGDLVMDEQAREVTRGGVVIELSRTEFELLRFLMRNPRRVLSKAQILDRVWSYDFGGRAHVVELYISYLRKKIDAGRTPLIHTVRGVGYVLKPDVS
>NC_016582.1|WP_043489772.1|3796110_3797586_+|HAMP-domain-containing-protein
MRAVLPRTLRARLTAGLVVLLAAASLAVGLTTVLALEGFLVRRLDQQLTAAGGRFPASLEHGERPDADNRPDTRGQSAYTFGARLKGGEATQAAVVHDNTDTRVPLTGADQQALAQLPVDGRGHDVRLSAIGAYRVLAVAGDDGDVLITGLPLRPVAETVHRVELVEAVVFGSALAVTGVAGALWVRLSLRPLRRVTATAAGVARLPLASGEVAMPAPVPDTDPRTEVGQVGAALNRMLGHVGDALARRHAGEERLRQFAADASHELRTPVANVRGHAELALRHHGPVPAEVRHALERIQSESQRMSTLVDDLLLLARLDAGRPLARGSVDLTRLVLDATGDARAAGPDHRWTLELPEEPVTVTGDEHRLQQVVANLLANARTHTPPGTEVAVRLGVRAGQTGLTELTVADDGPGIPEALQAEVFERFARADPSRSRAAGNTGLGLAIVRAVVAAHGGTVEVVSRPGRTVFRVVLPDARAAEPDPTIVTQA
>NC_016582.1|WP_106436587.1|3797728_3799309_+|prolyl-oligopeptidase-family-serine-peptidase
MRATTASAVFATLLAGAALGLAPAAQAAPLAPLPTAAQAADSSVRFVDIPGDGGATLAANVVTPRGADGSQRLPLVVLPTSWALPQAEYLAQAQKLADSGYVVVSYNVRGFWQSGGEIETAGPPDVADASKVIDWALANTPADPDRIGMAGVSYGAGISLLASGFDKRIKAVAAMSGWADLVGSIYSGRTQHAQAAALLSGSGELLGRPSAELRQIFQDFLGSDLAKEKDIVEWGKKRSAATYLDRINANGAAIMLANAWGDSIFPPNTYAGFYEKLTGPKRLEFRPGDHATGELTGLLGLPNDTWNDARRWLDRYVKGERNGIDQERPVQLKSRTADGYEGYPSWSAVPSTQRRVDLGETRQITANADSGANAGTVLLTGALDQFLKIPPLVSVPLLSRERAAVWQTDRYGTAQRIRGTVRLHTTVTGDKSSGTAVAYLYDVDALGVGKLITNAPVTFHDRTPGTPFAVDLDLFSTAYDVPAGHRLALVVDTVDPLYIEHNPDGAHLTFSSPKADPSYLSVPVRD
>NC_016582.1|WP_014175495.1|3799319_3800183_-|amino-acid-ABC-transporter-permease
MTTTSALYDIPGPHARARHRAYGILAAVVLLLLLGWIVYALIDTGQFAAEKWRPFEYKGIQLLLLRGLGNTLKAFALAAALSLALGAVLAAGRLSDHGPVRWVATIVVEFFRAMPVLVMIFFIFVALKVQPLPALVAGLTLYNGSVLAEVFRAGVNSVERGQREAAYSLGLRKTQVMAYVLVPQGVRAMLPAIISQLVVALKDTSLGFLITYEEFLHAGKLIAGNLDYGLPFIPVVMVISPVYIGMCMLLSWFANWVAKRERRSVKTEAVRVAPAEPATMLPGDTRT
>NC_016582.1|WP_014175496.1|3800179_3800824_-|amino-acid-ABC-transporter-permease
MDVLTHNFSLYGEGFLGTVELTVYASLLALALGVLMAGFRVAPVAPLRVFGTAWVTVLRNTPLTLLFFAVMLGLPRFGLVLPFFTFAVLALGCYTSAFICEAVRSGINTVPVGQGEAARSLGMNFPQTLGSVVLPQAFRTVIPPIGSTLIALAKNSAIAGSFSVTELLGTYKPLNERGYSIIWTFVWIALGYLIITLAISALFHVLERRWGVPR

Crispr_ID: NC_016582_7

• CRISPR_ID: NC_016582_7
• CRISPR_location: 4395947-4396134
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_016582_7

Consensus_repeat	Method
TCACCGACCCGCTGGGCCACACGACCCG	CRISPRCasFinder

spacers of NC_016582_7

>7.1|4395975|65|NC_016582|CRISPRCasFinder
CTATACGGACTCCCAAGGCAACACCACCACGTACGTGTGCAACGAGGCGTACAAGGTCGTCGCCG
>7.2|4396068|38|NC_016582|CRISPRCasFinder
CACGGAATGGGACGAGACCAACCGCCATCCCCTCGCCG

CRISPR arrays and Neighbor proteins around NC_016582_7

CRISPR arrays

The CRISPR arrays of NC_016582_7

>merge|NC_016582|7|4395947-4396134|CRISPRCasFinder
ACTACGACACGCAGGCCCGTACCACCCGCTATACGGACTCCCAAGGCAACACCACCACGTACGTGTGCAACGAGGCGTACAAGGTCGTCGCCGAGACCGATCCGCTGGGGAACACGACCCGCACGGAATGGGACGAGACCAACCGCCATCCCCTCGCCGTCACCGACCCCCTGGGCCACACCACGCAC

>NC_016582|7|6|4395947-4396134|CRISPRCasFinder
ACTACGACACGCAGGCCCGTACCACCCG	CTATACGGACTCCCAAGGCAACACCACCACGTACGTGTGCAACGAGGCGTACAAGGTCGTCGCCG
AGACCGATCCGCTGGGGAACACGACCCG	CACGGAATGGGACGAGACCAACCGCCATCCCCTCGCCG
TCACCGACCCCCTGGGCCACACCACGCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014175978.1|4402297_4402771_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014175975.1|4399949_4400096_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014175974.1|4399497_4399836_-|hypothetical-protein	unknown	unknown	gnl|CDD|173872
NC_016582.1|WP_014175963.1|4378209_4378668_-|tetratricopeptide-repeat-protein	unknown	unknown	unknown
NC_016582.1|WP_014175981.1|4405565_4405970_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014175970.1|4389788_4390250_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_078610415.1|4401682_4401904_+|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NC_016582.1|WP_014175979.1|4402779_4404939_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_043486638.1|4379490_4380861_-|insulinase-family-protein	unknown	unknown	gnl|CDD|223685
NC_016582.1|WP_014175971.1|4390271_4392575_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014175967.1|4383509_4383797_-|30S-ribosomal-protein-S15	unknown	unknown	gnl|CDD|180170
NC_016582.1|WP_043486640.1|4400808_4401696_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197775
NC_016582.1|WP_158104648.1|4405171_4405477_-|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
NC_016582.1|WP_143675735.1|4392596_4393238_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014175964.1|4378677_4379430_-|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl|CDD|234595
NC_016582.1|WP_014175976.1|4400165_4400579_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_016582.1|WP_014175966.1|4380857_4383110_-|polyribonucleotide-nucleotidyltransferase	unknown	unknown	gnl|CDD|131743
NC_016582.1|WP_014175969.1|4385659_4389616_+|type-VII-secretion-protein-EccC	unknown	unknown	gnl|CDD|274858
NC_016582.1|WP_043489992.1|4384015_4385485_-|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl|CDD|274855
NC_016582.1|WP_143675734.1|4398632_4398893_+|hypothetical-protein	unknown	unknown	gnl|CDD|380164

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014175974.1|4399497_4399836_-|hypothetical-protein	gnl|CDD|173872	cd08507, PBP2_SgrR_like, The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold. A novel family of SgrR transcriptional regulator contains a two-domain structure with an N terminal DNA-binding domain of the winged helix family and a C-terminal solute-binding domain. The C-terminal domain shows strong homology with the ABC-type oligopeptide-binding protein family, a member of the type 2 periplasmic-binding fold protein (PBP2) superfamily that also includes the C-terminal substrate-binding domain of LysR-type transcriptional regulators. SgrR (SugaR transport-related Regulator) is negatively autoregulated and activates transcription of divergent operon SgrS, which encodes a small RNA required for recovery from glucose-phosphate stress. Hence, the small RNA SgrS and SgrR, the transcription factor that controls sgrS expression, are both required for recovery from glucose-phosphate stress. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	0.000254512
NC_016582.1|WP_043486640.1|4400808_4401696_+|helix-turn-helix-domain-containing-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	1.01827e-08
NC_016582.1|WP_078610415.1|4401682_4401904_+|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.90604e-17
NC_016582.1|WP_043486638.1|4379490_4380861_-|insulinase-family-protein	gnl|CDD|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	5.23692e-122
NC_016582.1|WP_014175967.1|4383509_4383797_-|30S-ribosomal-protein-S15	gnl|CDD|180170	PRK05626, rpsO, 30S ribosomal protein S15; Reviewed.	2.70026e-52
NC_016582.1|WP_158104648.1|4405171_4405477_-|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.15567e-06
NC_016582.1|WP_014175964.1|4378677_4379430_-|4-hydroxy-tetrahydrodipicolinate-reductase	gnl|CDD|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	1.42803e-97
NC_016582.1|WP_014175976.1|4400165_4400579_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	6.04659e-12
NC_016582.1|WP_014175966.1|4380857_4383110_-|polyribonucleotide-nucleotidyltransferase	gnl|CDD|131743	TIGR02696, polyribonucleotide_nucleotidyltransferase, guanosine pentaphosphate synthetase I/polynucleotide phosphorylase. Sohlberg, et al. present characterization of two proteins from Streptomyces coelicolor. The protein in this family was shown to have poly(A) polymerase activity and may be responsible for polyadenylating RNA in this species. Reference 2 showed that a nearly identical plasmid-encoded protein from Streptomyces antibioticus is a bifunctional enzyme that acts also as a guanosine pentaphosphate synthetase.	0
NC_016582.1|WP_014175969.1|4385659_4389616_+|type-VII-secretion-protein-EccC	gnl|CDD|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NC_016582.1|WP_043489992.1|4384015_4385485_-|type-VII-secretion-integral-membrane-protein-EccD	gnl|CDD|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	3.46674e-34
NC_016582.1|WP_143675734.1|4398632_4398893_+|hypothetical-protein	gnl|CDD|380164	NF033154, endonuc_SmrA, DNA endonuclease SmrA. YdaL is a small endonuclease with homology to the C-terminal domain found in the endonuclease MutS2, but not found in the related mismatch repair protein MutS. The biological role of this endonuclease is not yet known. As one of two Small MutS2-Related proteins in E. coli, This protein was designated SmrA by Gui, et al. (PMID:21276852). The term SMR is much better known for describing a large family of Small Multidrug Resistance (SMR) efflux transporters, but in that context is used with three capital letters.	0.000438333

Protein sequences

>NC_016582.1|WP_143675735.1|4392596_4393238_+|hypothetical-protein
MILKPLLSTRSKGIAATLFLVLGAGTWWAANNSRSDTHTIKIPQRICHNRISGEKAAPLLLAKGSKYTEDAKTFGGWSLLGTCEAKVDDSRIYVSYQDALGHKRSYRPKGIPVSLGKAYGSLTTGGAINLYVSCTNTPRTATEWLLIGANATMVGNQIDDGRKLNKSSRGLQALTEFTAQAVRDLTQDWFKCPGADQLPDGPVTIHWDKPAVR
>NC_016582.1|WP_014175971.1|4390271_4392575_+|hypothetical-protein
MAHLTFDDLYHISLTSLGSAADDWKEMVDQLETLATDARDGMVKQSEAARWAGVNADVTRPFVRKTGKEFSDAHAEAKAIWAMLRDAHKELAALQSALKEAVDVDAKNKQIQVTGLPDGTVQCVYLHRRDTNDEHTTAQLDYKDRLKHRINNLIAQADDIDNSASSALKKIHGNDSHDFGHAKYDSLDDAQSARAVQLARKSLAKYRDGGELSITELAELKRLFAQNSKDREFAVDFYKALGPKDALRFQAEIAFDAQNEGDKTQLKLAQSIQTSMGESLATATRPPTGKDDPNTAFREDRDYLGKAWQTDLKRVGRAPLTFQRNSARVEIRGYQVLGAILRHGSYDKSFLTPIAEDMVTFERKHPGAWPQPHNSYSRLGADGFGLNLDKDGGPGWDPMAGLLEGLSHSPGASTEFFHGSTGEGEHDGLKKISNLDYFLGDKDGKGAREWAYGAVGTKVSDTENFGKEALGHALESATSGRPYDSDAPAKNHTQEQADIFDSVVKRVAANPELFKGDGELAPIAGSLGNMSAEYMYDIQRVYAGGDESGYIRDTGAEPDLSKPEDKHTLDLFLKTTTADPDAYAAVTQAQELVTAETLRQAITHRGDNEDIGNLAEIAVTPGAMVEGNAAQGRADAIAAADDSAQKAQEYNDSLTAGDGWIGRFVDLGIGAIDNIPVAGDVAGWVIEDAREAVLDHRAADPDDAAKKIQENKDAYLTTERVKRAERAKQAFYDAATQAGIDAKNQSVKNAAQQVYNAAYSANAVEAS
>NC_016582.1|WP_014175970.1|4389788_4390250_+|hypothetical-protein
MSFEEEWNGLRAEATTRMRLNEAGKGSSGGGGGSGDLIVHQDDLGRVGHEAFLLHDRLKKAGDMTRGAKDDGSTIKAASTLTNHHFTLGGALTTMAMTWNDQLKTLLQACAHISNHLDYSKKSQAHTDAKIAADMARLDGTAMPVSEISKYYK
>NC_016582.1|WP_014175969.1|4385659_4389616_+|type-VII-secretion-protein-EccC
MSQVVVKRQPRALPPEVPSEELRLESPPELPRGQQEGVLMQLLPTLGMASSMVYFFMPGAAPMMKIMGVMMMFSTLGMTVAMFIRHRQGSQGQLADMRRDYLKYLAQTRRTVRRTARSQRDAQFYLHPSPDQLWSVVAEGSRVWERRASDNDFAQIRIGLGSQQLSTPLVAPDTAAVDDLEPLTAGAMQKFLATQGSLEYMPMAVSLRAFYHVTVSGEPDSVRGTARALVGELATFHSPEDLVIAVVAPRSSAAYWDWTKWLPHLQVPGAIDGAGSRRLFSDSLAELEELLKGRLEGRSRFSKDAQPLLDQPHVVVVLDGGMVPPESAFAAQEGLQGVTVIEVVAGDLDELRGGLSVIVRPGKLELLSQVAAYDGAPDSLSLEAADALARQLAPLRMGGGDDDEPLLANLDFTDLLGLGDAGSVDVSRTWRPRSMAERLRVPIGVGEDGSPVMLDLKEAAQDGMGPHGLCVGATGSGKSELLRTLVLGLAVTHSSETLNFVLADFKGGATFAGMSQLPHVAAVITNLADDLTLVDRMRDSITGELQRRQELLRSAGNYANIHDYEKARAAGAPLEPVASLVLVIDEFSELLTAKPDFIDMFIQIGRIGRSLGVHLLLASQRLEEGRLRGLETYLSYRIGLRTFSAAESRTALGVPDAYHLPSVPGSGYLKFGTDEMTRFKAAYVSGVYRTGVAPADFDGTSLPIERRPVIFTATPVPVTYTTPDPAALTTPSRQEDDALADTVLDVIVRRLEGQGAPAHQVWLPPLDEAPSLDQLLPALSPVEGRGLTAPEYPRLGNLVVPLGLIDKPFEQRRDVLYRDFSGAAGHMLVVGGPQSGKSTLMRTLISAFALTHTPAEVQFYGLDFGGGGMSSVADLPHVGGIASRLDPERVRRTIAEVAGILARREEYFRAKNIDSIGTYRRQRARGEHAEQGWGDVFLIIDGWANFRQEYDMLEGVVADIAGRGLGYGIHIVVTASRNMEVRAALKDQLLNRLEMRLGDTMDSEFDRKVAANVPVGVPGRGQLPEKLHFMGAQPRIDSGSDPEDITDASGELVRAVTTNWNGPHAPRVRLLPRRLRAEDLPKGFEYPQQGIAIGIDETNLEPVFVDFESDPFFLIFGESESGKTALLRLIAKQITERYGPDEAKIVVGDYRRSLLDVIPDSHLLEYAPIASALQVHTSALNGLMERRAPKPDITPQQLRDRSWWSGPQFFIIIDDYELVSTSSGNPMAVLTDNLPFARDVGMRFIIARNSAGASRSMFESFMQRIKELGAQGVMLSGDPTEGDLLGGVRPRPMPPGRGFFVSRKRGTPLVQLGWLPDQ
>NC_016582.1|WP_043489992.1|4384015_4385485_-|type-VII-secretion-integral-membrane-protein-EccD
MSTSATTGFCRVTVVAPDSRIDVALPEDIAVADVYPEILRLTGQTQPVGAPTGYHLVRRDGTVLDGSLSLGAQQVLDGELLSLRPFAESLPPAVYDDVSDAIASAVTRDRTLWSDRFLRAFGLFGGSLLLVLMGFVLWFADPLKHDMHGLPGIIAAAVAVLLTALAGVRARVYEDRASAIALGLAALPHAMIAGSGLLALDKGEGIGRLQFLLGCVAVLVVSVALVVAMPTGDAPFVAAVFASIVGTLATFCAILTEVSPTETAAVCAAVAIGAIAFLPGLSARVARLPIGYAAPRSAAEDDDLDPVSGPAPEPVDAERIAAQARRGHEMLLGLVGGCSAVVVGASAVLGFSDNVWGQVLALVSGLAMLLRARLFRYTAQVASVLAAGLVGLGLLVLGLSLNPPADAMFKLLVRHDSGPLDVRTIWLAASVVAGAALITGIALIIPKKGLSPFWGRFSDLAESALLLSLVPLALAVLDVYSSARSLTSG
>NC_016582.1|WP_014175967.1|4383509_4383797_-|30S-ribosomal-protein-S15
MSLDAATKKQIMADFATKEGDTGSPEVQVALLSRRISDLTEHLKTHKHDHHSRRGLLLLVGQRRRLLQYLAKKDITRFRALVERLGIRRGAAGAK
>NC_016582.1|WP_014175966.1|4380857_4383110_-|polyribonucleotide-nucleotidyltransferase
MENETHYAEAVIDNGAFGTRTIRFETGRLARQAAGSAVAYLDDDTMVLSATTASKNPKDQLDFFPLTVDVEERMYAAGRIPGSFFRREGRPSEDAILTCRLIDRPLRPSFKKGLRNEIQIVETIMALNPDHLYDVVAINAASCSTQLAGLPFSGPIGGTRVALIRGQWVAFPTHSELEDAVFDMVVAGRVLEDGDVAIMMVEAEATDKTIQLVKDGAEAPTEEVVAAGLEAAKPFIKVLCKAQSDLAAKAAKPTGEFPIFLDYQDDVLEALTAAVRDELAQALTIAGKQERETELDRVKGLAAEKLLPQFEGREKEISAAYRSLTKTLVRERVIKEKKRIDGRGVTDIRTLAAEVEAIPRVHGSALFERGETQILGVTTLNMLRMEQQLDTLAPETRKRYMHNYNFPPYSTGETGRVGSPKRREIGHGALAERALLPVLPSREDFPYAIRQVSEALSSNGSTSMGSVCASTMSLLNAGVPLRAPVAGIAMGLISQEIDGETHYVTLTDILGAEDAFGDMDFKVAGTKTFVTALQLDTKLDGIPASVLAAALKQARDARLHILDVMNEAIDVPDEMSPNAPRIITVKIPVDKIGEVIGPKGKMINQIQEDTGADITIEDDGTIYIGAADGPAAEAARATINGIANPTMPEVGERYLGTVVKTTTFGAFVSLLPGKDGLLHISQIRKLAGGKRVENVEDVLKVGAKVQVEIAEIDQRGKLSLIPVIEDEEGSDASKDEAKDAADSGSAPDAK
>NC_016582.1|WP_043486638.1|4379490_4380861_-|insulinase-family-protein
MTSRAHAGAGGGGGGVARTQTLLKGENGIGTVRRTTLPGGLRIVTETLPSVRSATFGIWAHVGSRDETPVLNGATHYLEHLLFKGTQRRSALDISSAIDAVGGEMNAFTAKEYTCYYARVLDTDLPLAIDVVCDMLTGSLIDAADVEAERGVVLEEIAMTEDDPGDCVHDLFAHTMLGDTPLGRPVLGTVDTVNGLGRDQIARFYKKHYDPTHLVVAAAGNVDHAAVVRQVRKAFDKAGALSRTDAVPVAPRDGTRTIRAAGRVEVQGRKTEQAHVVLGMPGIARTDDRRWALGVLNTALGGGMSSRLFQEVREKRGLAYSVYSYTSGFADCGLFGVYAGCRPSQAADVLKICRDELDHVAQHGLTDEELRRAVGQLRGSTVLGLEDTGALMNRIGKSELCWGDQMSVDDMLARMAAVTPDEVREVAHDVLGQRPSLSVIGPLKDKQASRLHEAVA
>NC_016582.1|WP_014175964.1|4378677_4379430_-|4-hydroxy-tetrahydrodipicolinate-reductase
MSKLRVAVLGAKGRIGSEAVRAVEAAEDMELVAALGRGDKLETMAEAGAEVAVELTDPDSVMGNLEFCVRHGIHGVVGTTGWTDERLAQLRGWLEAAPGTGVLIAPNFSIGAVLTMQFARQAARFFESVEVIELHHPNKVDAPSGTAARTAQLIAAAREQAGCAPQPDATSTALEGARGAEVDGVRVHSVRLRGLLAHQEVLLGGEGETLTIRHDSTHHSSFMPGVLLGVRRVVSAPGLTLGLEHFLDLD
>NC_016582.1|WP_014175963.1|4378209_4378668_-|tetratricopeptide-repeat-protein
MRAKITYFVLAAVLVVYFVLVGSRGVLLIEQGTPLTVAFGVAVLVLPFIGAWFLWKTTVFARSANRLARELEAEGGLPVDELVRTPGGRIDRDSADAVFAKRRAETEESPDDWRSWFRLAVAYYDARDTVRARRAMQRAIALHDGRPVRAQS
>NC_016582.1|WP_143675734.1|4398632_4398893_+|hypothetical-protein
MDRSLLDALASSFTEDGLVEQEAVFRKLRDLGKSPIEAIYVASRVLGLSLPEAKTALYQSTSWRDQHENWQSVQSALNDGPNNDLR
>NC_016582.1|WP_014175974.1|4399497_4399836_-|hypothetical-protein
MVAEGCRGWIGYWTYSDEPQDQPTPIAEIDTEATVWSMSGRTLTEACAANLAFFNDHPAAELARLADRLATKLGVPVSRRDYDALHVPDLAVDPDVLFDEFNGAELARLTGR
>NC_016582.1|WP_014175975.1|4399949_4400096_-|hypothetical-protein
MSMSDDRMARYSREQLDGYFVPEDLRVLLTAHWEGCNETAELFGITLL
>NC_016582.1|WP_014175976.1|4400165_4400579_-|ATP-binding-protein
MLGRDRVVVHARHRAASWVREGWRLPEAAFQIESVVGELCANALRHGGGLASFDLILCEATAYCPPSLRILVGDYLPHAHPRMSCDPNAELGEHGRGLLMVTALTAGWGWHRIGADLKQVWCKVILPLDALPWLVRS
>NC_016582.1|WP_043486640.1|4400808_4401696_+|helix-turn-helix-domain-containing-protein
MAWKKSTVSKSVYRRQLAARLRELREDTELTLAEVARQVEVSQGSLSRIETGDRGTTPLLVKALLDCYEVTDTTLREDLLDLVRADQAQKRPWWKKYAAVVNTTQYGGYLTLESSATSLRTYQPLLVPGLLQTEAYAREIITEMRPDLSARQVQALVDVRMRRQAMLDTENAPTLWAVIDEAAIRRRIRSTEVARQQLERLVHASEHPRITIQFLPFAAGAHAGLYGSFMLMDFPAPTPEVVWVENLTNSVCFEDPGDVDRYIEVFDHLRSRALMPSETCRRFRTIARELQHEEH
>NC_016582.1|WP_078610415.1|4401682_4401904_+|DUF397-domain-containing-protein
MKNINATLSALDSEGDHWRKSSYSGGNDDCVELAITQGHIAVRDSKRPDLPYASFTAPAWHEFISVIAAGTLT
>NC_016582.1|WP_014175978.1|4402297_4402771_+|hypothetical-protein
MTFEDEWSKLRTDAAAGRKSTHMQLNQTDPPGPSLPGTLTLKSSASKKKSAVNALTTDVEPDTKKAGECVDETTEKAEKEFKDWATGSGLTDALKGWHTSVKALQARLSQEKTALSGTNKYFLGNDFQVGSELTTAVPSAQYSDNTPFSSRISDYYR
>NC_016582.1|WP_014175979.1|4402779_4404939_+|hypothetical-protein
MLTYHQVMTIDLSLLETAATKWDEAAKQFEAVRKIYDSKVKSVGLDGTWSGVSLLVARPNMQVTDEQFTAAPKEARAIASILRDAHTQFVDLRGKVKSAVADAVKAGMKVSEAGIASYDYSKASSSEANAARHDPDLHSTEQSWTRYIEAAVRAVDDADQGVKLALKAAVQDPNVLDPAANGFNGKAEGDIEKVEAKEAEDLATRLNSGDKLSDKEMAEFQRLFRDNEHNKAFSQTFLAGIGPNGTIDLNLKLNDLAKGDDKKDFRALQEGVATSLATATKSPSDPFYKKWREDLRKAGAKDFDGGTVPLYGYQSFVELMTHGKNYGKQFLTDVGNDIIALEKSDDLGTGRWDAWQGAGLAPHKDVATDPLDTLLGIMSQQPNVATSFLDPGADGKNDHLQYLLKDRHWPTTSMPNSIGISHMDLPGNRMGFGAALEAAATGNVPGSDHTLGFHTEAESRVMHDTIKILDDGRKGTDVPYNLRSNLGRMLVDYTPETHEILSGTGPYMDKDGVWHDGTGGKDAHMSVPKESLTRIMRGVAEDGKAFGEMFDAEKFYSAGTLSQTNFSDPNERAAAIEGASHVFGFYDGINSDIVRDNKDGAVARANHIQTAEFVITGGMQAAASALKGQPTGFITDAAYRILYAAAYDWKEDQIAQANAAAAQQTEYHFTTGQKQVNHMVAGWAQENGYDKETGLSRHLVGSGQERYDSARTEALIYLD
>NC_016582.1|WP_158104648.1|4405171_4405477_-|WXG100-family-type-VII-secretion-target
MSTPDGMLVDYESVLQLATQLRTAASNVRKEMQDIQGAVKKVTAGWEGEAHQAMLAAEKQFQARADHIQGLVTRVATLVESGKDAYHATDVKASKLFSVSY
>NC_016582.1|WP_014175981.1|4405565_4405970_-|hypothetical-protein
MSKQRVSDDAFRIFTNELDQSIQGFASNMKLMADILATVDSGWQGQGAGAFKKAQMDLEQDHDAVRRLVDGIREAVALTHRASGANDDDIASQLKGIDVNGAAAGGHITPGSSVGGLGAGTDAPIASYSKVDGF

Crispr_ID: NC_016582_8

• CRISPR_ID: NC_016582_8
• CRISPR_location: 4396295-4396511
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NC_016582_8

Consensus_repeat	Method
TCACCGACCCGCTGGGCCACACGACCCG	CRISPRCasFinder

spacers of NC_016582_8

>8.1|4396323|35|NC_016582|CRISPRCasFinder
CTACACCTACGGCACATCGGGCCACCTTGCGTCGG
>8.2|4396386|35|NC_016582|CRISPRCasFinder
GGTCGACACCAATGCGGCAGGTCTGCCCGTCGCCA
>8.3|4396449|35|NC_016582|CRISPRCasFinder
TATCCGCCGCGGCCCGCACGGCCGCGTCACAGCCG

CRISPR arrays and Neighbor proteins around NC_016582_8

CRISPR arrays

The CRISPR arrays of NC_016582_8

>merge|NC_016582|8|4396295-4396511|CRISPRCasFinder
CCACCGACCCCACCGGCGCCACCACCCACTACACCTACGGCACATCGGGCCACCTTGCGTCGGTCACGGACCCTCTGGGCCATACCACCGAGGTCGACACCAATGCGGCAGGTCTGCCCGTCGCCATCACCGACCCGCTGGGCCACACGACCCGTATCCGCCGCGGCCCGCACGGCCGCGTCACAGCCGTCACCGACCCGCTGGGCCACACCACCCG

>NC_016582|8|7|4396295-4396511|CRISPRCasFinder
CCACCGACCCCACCGGCGCCACCACCCA	CTACACCTACGGCACATCGGGCCACCTTGCGTCGG
TCACGGACCCTCTGGGCCATACCACCGA	GGTCGACACCAATGCGGCAGGTCTGCCCGTCGCCA
TCACCGACCCGCTGGGCCACACGACCCG	TATCCGCCGCGGCCCGCACGGCCGCGTCACAGCCG
TCACCGACCCGCTGGGCCACACCACCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014175978.1|4402297_4402771_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014175975.1|4399949_4400096_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014175974.1|4399497_4399836_-|hypothetical-protein	unknown	unknown	gnl|CDD|173872
NC_016582.1|WP_014175963.1|4378209_4378668_-|tetratricopeptide-repeat-protein	unknown	unknown	unknown
NC_016582.1|WP_014175981.1|4405565_4405970_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014175970.1|4389788_4390250_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_078610415.1|4401682_4401904_+|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NC_016582.1|WP_014175979.1|4402779_4404939_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_043486638.1|4379490_4380861_-|insulinase-family-protein	unknown	unknown	gnl|CDD|223685
NC_016582.1|WP_014175971.1|4390271_4392575_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014175967.1|4383509_4383797_-|30S-ribosomal-protein-S15	unknown	unknown	gnl|CDD|180170
NC_016582.1|WP_043486640.1|4400808_4401696_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197775
NC_016582.1|WP_158104648.1|4405171_4405477_-|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
NC_016582.1|WP_143675735.1|4392596_4393238_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014175964.1|4378677_4379430_-|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl|CDD|234595
NC_016582.1|WP_014175976.1|4400165_4400579_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_016582.1|WP_014175966.1|4380857_4383110_-|polyribonucleotide-nucleotidyltransferase	unknown	unknown	gnl|CDD|131743
NC_016582.1|WP_014175969.1|4385659_4389616_+|type-VII-secretion-protein-EccC	unknown	unknown	gnl|CDD|274858
NC_016582.1|WP_043489992.1|4384015_4385485_-|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl|CDD|274855
NC_016582.1|WP_143675734.1|4398632_4398893_+|hypothetical-protein	unknown	unknown	gnl|CDD|380164

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014175974.1|4399497_4399836_-|hypothetical-protein	gnl|CDD|173872	cd08507, PBP2_SgrR_like, The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold. A novel family of SgrR transcriptional regulator contains a two-domain structure with an N terminal DNA-binding domain of the winged helix family and a C-terminal solute-binding domain. The C-terminal domain shows strong homology with the ABC-type oligopeptide-binding protein family, a member of the type 2 periplasmic-binding fold protein (PBP2) superfamily that also includes the C-terminal substrate-binding domain of LysR-type transcriptional regulators. SgrR (SugaR transport-related Regulator) is negatively autoregulated and activates transcription of divergent operon SgrS, which encodes a small RNA required for recovery from glucose-phosphate stress. Hence, the small RNA SgrS and SgrR, the transcription factor that controls sgrS expression, are both required for recovery from glucose-phosphate stress. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	0.000254512
NC_016582.1|WP_043486640.1|4400808_4401696_+|helix-turn-helix-domain-containing-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	1.01827e-08
NC_016582.1|WP_078610415.1|4401682_4401904_+|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.90604e-17
NC_016582.1|WP_043486638.1|4379490_4380861_-|insulinase-family-protein	gnl|CDD|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	5.23692e-122
NC_016582.1|WP_014175967.1|4383509_4383797_-|30S-ribosomal-protein-S15	gnl|CDD|180170	PRK05626, rpsO, 30S ribosomal protein S15; Reviewed.	2.70026e-52
NC_016582.1|WP_158104648.1|4405171_4405477_-|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.15567e-06
NC_016582.1|WP_014175964.1|4378677_4379430_-|4-hydroxy-tetrahydrodipicolinate-reductase	gnl|CDD|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	1.42803e-97
NC_016582.1|WP_014175976.1|4400165_4400579_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	6.04659e-12
NC_016582.1|WP_014175966.1|4380857_4383110_-|polyribonucleotide-nucleotidyltransferase	gnl|CDD|131743	TIGR02696, polyribonucleotide_nucleotidyltransferase, guanosine pentaphosphate synthetase I/polynucleotide phosphorylase. Sohlberg, et al. present characterization of two proteins from Streptomyces coelicolor. The protein in this family was shown to have poly(A) polymerase activity and may be responsible for polyadenylating RNA in this species. Reference 2 showed that a nearly identical plasmid-encoded protein from Streptomyces antibioticus is a bifunctional enzyme that acts also as a guanosine pentaphosphate synthetase.	0
NC_016582.1|WP_014175969.1|4385659_4389616_+|type-VII-secretion-protein-EccC	gnl|CDD|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NC_016582.1|WP_043489992.1|4384015_4385485_-|type-VII-secretion-integral-membrane-protein-EccD	gnl|CDD|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	3.46674e-34
NC_016582.1|WP_143675734.1|4398632_4398893_+|hypothetical-protein	gnl|CDD|380164	NF033154, endonuc_SmrA, DNA endonuclease SmrA. YdaL is a small endonuclease with homology to the C-terminal domain found in the endonuclease MutS2, but not found in the related mismatch repair protein MutS. The biological role of this endonuclease is not yet known. As one of two Small MutS2-Related proteins in E. coli, This protein was designated SmrA by Gui, et al. (PMID:21276852). The term SMR is much better known for describing a large family of Small Multidrug Resistance (SMR) efflux transporters, but in that context is used with three capital letters.	0.000438333

Protein sequences

>NC_016582.1|WP_143675735.1|4392596_4393238_+|hypothetical-protein
MILKPLLSTRSKGIAATLFLVLGAGTWWAANNSRSDTHTIKIPQRICHNRISGEKAAPLLLAKGSKYTEDAKTFGGWSLLGTCEAKVDDSRIYVSYQDALGHKRSYRPKGIPVSLGKAYGSLTTGGAINLYVSCTNTPRTATEWLLIGANATMVGNQIDDGRKLNKSSRGLQALTEFTAQAVRDLTQDWFKCPGADQLPDGPVTIHWDKPAVR
>NC_016582.1|WP_014175971.1|4390271_4392575_+|hypothetical-protein
MAHLTFDDLYHISLTSLGSAADDWKEMVDQLETLATDARDGMVKQSEAARWAGVNADVTRPFVRKTGKEFSDAHAEAKAIWAMLRDAHKELAALQSALKEAVDVDAKNKQIQVTGLPDGTVQCVYLHRRDTNDEHTTAQLDYKDRLKHRINNLIAQADDIDNSASSALKKIHGNDSHDFGHAKYDSLDDAQSARAVQLARKSLAKYRDGGELSITELAELKRLFAQNSKDREFAVDFYKALGPKDALRFQAEIAFDAQNEGDKTQLKLAQSIQTSMGESLATATRPPTGKDDPNTAFREDRDYLGKAWQTDLKRVGRAPLTFQRNSARVEIRGYQVLGAILRHGSYDKSFLTPIAEDMVTFERKHPGAWPQPHNSYSRLGADGFGLNLDKDGGPGWDPMAGLLEGLSHSPGASTEFFHGSTGEGEHDGLKKISNLDYFLGDKDGKGAREWAYGAVGTKVSDTENFGKEALGHALESATSGRPYDSDAPAKNHTQEQADIFDSVVKRVAANPELFKGDGELAPIAGSLGNMSAEYMYDIQRVYAGGDESGYIRDTGAEPDLSKPEDKHTLDLFLKTTTADPDAYAAVTQAQELVTAETLRQAITHRGDNEDIGNLAEIAVTPGAMVEGNAAQGRADAIAAADDSAQKAQEYNDSLTAGDGWIGRFVDLGIGAIDNIPVAGDVAGWVIEDAREAVLDHRAADPDDAAKKIQENKDAYLTTERVKRAERAKQAFYDAATQAGIDAKNQSVKNAAQQVYNAAYSANAVEAS
>NC_016582.1|WP_014175970.1|4389788_4390250_+|hypothetical-protein
MSFEEEWNGLRAEATTRMRLNEAGKGSSGGGGGSGDLIVHQDDLGRVGHEAFLLHDRLKKAGDMTRGAKDDGSTIKAASTLTNHHFTLGGALTTMAMTWNDQLKTLLQACAHISNHLDYSKKSQAHTDAKIAADMARLDGTAMPVSEISKYYK
>NC_016582.1|WP_014175969.1|4385659_4389616_+|type-VII-secretion-protein-EccC
MSQVVVKRQPRALPPEVPSEELRLESPPELPRGQQEGVLMQLLPTLGMASSMVYFFMPGAAPMMKIMGVMMMFSTLGMTVAMFIRHRQGSQGQLADMRRDYLKYLAQTRRTVRRTARSQRDAQFYLHPSPDQLWSVVAEGSRVWERRASDNDFAQIRIGLGSQQLSTPLVAPDTAAVDDLEPLTAGAMQKFLATQGSLEYMPMAVSLRAFYHVTVSGEPDSVRGTARALVGELATFHSPEDLVIAVVAPRSSAAYWDWTKWLPHLQVPGAIDGAGSRRLFSDSLAELEELLKGRLEGRSRFSKDAQPLLDQPHVVVVLDGGMVPPESAFAAQEGLQGVTVIEVVAGDLDELRGGLSVIVRPGKLELLSQVAAYDGAPDSLSLEAADALARQLAPLRMGGGDDDEPLLANLDFTDLLGLGDAGSVDVSRTWRPRSMAERLRVPIGVGEDGSPVMLDLKEAAQDGMGPHGLCVGATGSGKSELLRTLVLGLAVTHSSETLNFVLADFKGGATFAGMSQLPHVAAVITNLADDLTLVDRMRDSITGELQRRQELLRSAGNYANIHDYEKARAAGAPLEPVASLVLVIDEFSELLTAKPDFIDMFIQIGRIGRSLGVHLLLASQRLEEGRLRGLETYLSYRIGLRTFSAAESRTALGVPDAYHLPSVPGSGYLKFGTDEMTRFKAAYVSGVYRTGVAPADFDGTSLPIERRPVIFTATPVPVTYTTPDPAALTTPSRQEDDALADTVLDVIVRRLEGQGAPAHQVWLPPLDEAPSLDQLLPALSPVEGRGLTAPEYPRLGNLVVPLGLIDKPFEQRRDVLYRDFSGAAGHMLVVGGPQSGKSTLMRTLISAFALTHTPAEVQFYGLDFGGGGMSSVADLPHVGGIASRLDPERVRRTIAEVAGILARREEYFRAKNIDSIGTYRRQRARGEHAEQGWGDVFLIIDGWANFRQEYDMLEGVVADIAGRGLGYGIHIVVTASRNMEVRAALKDQLLNRLEMRLGDTMDSEFDRKVAANVPVGVPGRGQLPEKLHFMGAQPRIDSGSDPEDITDASGELVRAVTTNWNGPHAPRVRLLPRRLRAEDLPKGFEYPQQGIAIGIDETNLEPVFVDFESDPFFLIFGESESGKTALLRLIAKQITERYGPDEAKIVVGDYRRSLLDVIPDSHLLEYAPIASALQVHTSALNGLMERRAPKPDITPQQLRDRSWWSGPQFFIIIDDYELVSTSSGNPMAVLTDNLPFARDVGMRFIIARNSAGASRSMFESFMQRIKELGAQGVMLSGDPTEGDLLGGVRPRPMPPGRGFFVSRKRGTPLVQLGWLPDQ
>NC_016582.1|WP_043489992.1|4384015_4385485_-|type-VII-secretion-integral-membrane-protein-EccD
MSTSATTGFCRVTVVAPDSRIDVALPEDIAVADVYPEILRLTGQTQPVGAPTGYHLVRRDGTVLDGSLSLGAQQVLDGELLSLRPFAESLPPAVYDDVSDAIASAVTRDRTLWSDRFLRAFGLFGGSLLLVLMGFVLWFADPLKHDMHGLPGIIAAAVAVLLTALAGVRARVYEDRASAIALGLAALPHAMIAGSGLLALDKGEGIGRLQFLLGCVAVLVVSVALVVAMPTGDAPFVAAVFASIVGTLATFCAILTEVSPTETAAVCAAVAIGAIAFLPGLSARVARLPIGYAAPRSAAEDDDLDPVSGPAPEPVDAERIAAQARRGHEMLLGLVGGCSAVVVGASAVLGFSDNVWGQVLALVSGLAMLLRARLFRYTAQVASVLAAGLVGLGLLVLGLSLNPPADAMFKLLVRHDSGPLDVRTIWLAASVVAGAALITGIALIIPKKGLSPFWGRFSDLAESALLLSLVPLALAVLDVYSSARSLTSG
>NC_016582.1|WP_014175967.1|4383509_4383797_-|30S-ribosomal-protein-S15
MSLDAATKKQIMADFATKEGDTGSPEVQVALLSRRISDLTEHLKTHKHDHHSRRGLLLLVGQRRRLLQYLAKKDITRFRALVERLGIRRGAAGAK
>NC_016582.1|WP_014175966.1|4380857_4383110_-|polyribonucleotide-nucleotidyltransferase
MENETHYAEAVIDNGAFGTRTIRFETGRLARQAAGSAVAYLDDDTMVLSATTASKNPKDQLDFFPLTVDVEERMYAAGRIPGSFFRREGRPSEDAILTCRLIDRPLRPSFKKGLRNEIQIVETIMALNPDHLYDVVAINAASCSTQLAGLPFSGPIGGTRVALIRGQWVAFPTHSELEDAVFDMVVAGRVLEDGDVAIMMVEAEATDKTIQLVKDGAEAPTEEVVAAGLEAAKPFIKVLCKAQSDLAAKAAKPTGEFPIFLDYQDDVLEALTAAVRDELAQALTIAGKQERETELDRVKGLAAEKLLPQFEGREKEISAAYRSLTKTLVRERVIKEKKRIDGRGVTDIRTLAAEVEAIPRVHGSALFERGETQILGVTTLNMLRMEQQLDTLAPETRKRYMHNYNFPPYSTGETGRVGSPKRREIGHGALAERALLPVLPSREDFPYAIRQVSEALSSNGSTSMGSVCASTMSLLNAGVPLRAPVAGIAMGLISQEIDGETHYVTLTDILGAEDAFGDMDFKVAGTKTFVTALQLDTKLDGIPASVLAAALKQARDARLHILDVMNEAIDVPDEMSPNAPRIITVKIPVDKIGEVIGPKGKMINQIQEDTGADITIEDDGTIYIGAADGPAAEAARATINGIANPTMPEVGERYLGTVVKTTTFGAFVSLLPGKDGLLHISQIRKLAGGKRVENVEDVLKVGAKVQVEIAEIDQRGKLSLIPVIEDEEGSDASKDEAKDAADSGSAPDAK
>NC_016582.1|WP_043486638.1|4379490_4380861_-|insulinase-family-protein
MTSRAHAGAGGGGGGVARTQTLLKGENGIGTVRRTTLPGGLRIVTETLPSVRSATFGIWAHVGSRDETPVLNGATHYLEHLLFKGTQRRSALDISSAIDAVGGEMNAFTAKEYTCYYARVLDTDLPLAIDVVCDMLTGSLIDAADVEAERGVVLEEIAMTEDDPGDCVHDLFAHTMLGDTPLGRPVLGTVDTVNGLGRDQIARFYKKHYDPTHLVVAAAGNVDHAAVVRQVRKAFDKAGALSRTDAVPVAPRDGTRTIRAAGRVEVQGRKTEQAHVVLGMPGIARTDDRRWALGVLNTALGGGMSSRLFQEVREKRGLAYSVYSYTSGFADCGLFGVYAGCRPSQAADVLKICRDELDHVAQHGLTDEELRRAVGQLRGSTVLGLEDTGALMNRIGKSELCWGDQMSVDDMLARMAAVTPDEVREVAHDVLGQRPSLSVIGPLKDKQASRLHEAVA
>NC_016582.1|WP_014175964.1|4378677_4379430_-|4-hydroxy-tetrahydrodipicolinate-reductase
MSKLRVAVLGAKGRIGSEAVRAVEAAEDMELVAALGRGDKLETMAEAGAEVAVELTDPDSVMGNLEFCVRHGIHGVVGTTGWTDERLAQLRGWLEAAPGTGVLIAPNFSIGAVLTMQFARQAARFFESVEVIELHHPNKVDAPSGTAARTAQLIAAAREQAGCAPQPDATSTALEGARGAEVDGVRVHSVRLRGLLAHQEVLLGGEGETLTIRHDSTHHSSFMPGVLLGVRRVVSAPGLTLGLEHFLDLD
>NC_016582.1|WP_014175963.1|4378209_4378668_-|tetratricopeptide-repeat-protein
MRAKITYFVLAAVLVVYFVLVGSRGVLLIEQGTPLTVAFGVAVLVLPFIGAWFLWKTTVFARSANRLARELEAEGGLPVDELVRTPGGRIDRDSADAVFAKRRAETEESPDDWRSWFRLAVAYYDARDTVRARRAMQRAIALHDGRPVRAQS
>NC_016582.1|WP_143675734.1|4398632_4398893_+|hypothetical-protein
MDRSLLDALASSFTEDGLVEQEAVFRKLRDLGKSPIEAIYVASRVLGLSLPEAKTALYQSTSWRDQHENWQSVQSALNDGPNNDLR
>NC_016582.1|WP_014175974.1|4399497_4399836_-|hypothetical-protein
MVAEGCRGWIGYWTYSDEPQDQPTPIAEIDTEATVWSMSGRTLTEACAANLAFFNDHPAAELARLADRLATKLGVPVSRRDYDALHVPDLAVDPDVLFDEFNGAELARLTGR
>NC_016582.1|WP_014175975.1|4399949_4400096_-|hypothetical-protein
MSMSDDRMARYSREQLDGYFVPEDLRVLLTAHWEGCNETAELFGITLL
>NC_016582.1|WP_014175976.1|4400165_4400579_-|ATP-binding-protein
MLGRDRVVVHARHRAASWVREGWRLPEAAFQIESVVGELCANALRHGGGLASFDLILCEATAYCPPSLRILVGDYLPHAHPRMSCDPNAELGEHGRGLLMVTALTAGWGWHRIGADLKQVWCKVILPLDALPWLVRS
>NC_016582.1|WP_043486640.1|4400808_4401696_+|helix-turn-helix-domain-containing-protein
MAWKKSTVSKSVYRRQLAARLRELREDTELTLAEVARQVEVSQGSLSRIETGDRGTTPLLVKALLDCYEVTDTTLREDLLDLVRADQAQKRPWWKKYAAVVNTTQYGGYLTLESSATSLRTYQPLLVPGLLQTEAYAREIITEMRPDLSARQVQALVDVRMRRQAMLDTENAPTLWAVIDEAAIRRRIRSTEVARQQLERLVHASEHPRITIQFLPFAAGAHAGLYGSFMLMDFPAPTPEVVWVENLTNSVCFEDPGDVDRYIEVFDHLRSRALMPSETCRRFRTIARELQHEEH
>NC_016582.1|WP_078610415.1|4401682_4401904_+|DUF397-domain-containing-protein
MKNINATLSALDSEGDHWRKSSYSGGNDDCVELAITQGHIAVRDSKRPDLPYASFTAPAWHEFISVIAAGTLT
>NC_016582.1|WP_014175978.1|4402297_4402771_+|hypothetical-protein
MTFEDEWSKLRTDAAAGRKSTHMQLNQTDPPGPSLPGTLTLKSSASKKKSAVNALTTDVEPDTKKAGECVDETTEKAEKEFKDWATGSGLTDALKGWHTSVKALQARLSQEKTALSGTNKYFLGNDFQVGSELTTAVPSAQYSDNTPFSSRISDYYR
>NC_016582.1|WP_014175979.1|4402779_4404939_+|hypothetical-protein
MLTYHQVMTIDLSLLETAATKWDEAAKQFEAVRKIYDSKVKSVGLDGTWSGVSLLVARPNMQVTDEQFTAAPKEARAIASILRDAHTQFVDLRGKVKSAVADAVKAGMKVSEAGIASYDYSKASSSEANAARHDPDLHSTEQSWTRYIEAAVRAVDDADQGVKLALKAAVQDPNVLDPAANGFNGKAEGDIEKVEAKEAEDLATRLNSGDKLSDKEMAEFQRLFRDNEHNKAFSQTFLAGIGPNGTIDLNLKLNDLAKGDDKKDFRALQEGVATSLATATKSPSDPFYKKWREDLRKAGAKDFDGGTVPLYGYQSFVELMTHGKNYGKQFLTDVGNDIIALEKSDDLGTGRWDAWQGAGLAPHKDVATDPLDTLLGIMSQQPNVATSFLDPGADGKNDHLQYLLKDRHWPTTSMPNSIGISHMDLPGNRMGFGAALEAAATGNVPGSDHTLGFHTEAESRVMHDTIKILDDGRKGTDVPYNLRSNLGRMLVDYTPETHEILSGTGPYMDKDGVWHDGTGGKDAHMSVPKESLTRIMRGVAEDGKAFGEMFDAEKFYSAGTLSQTNFSDPNERAAAIEGASHVFGFYDGINSDIVRDNKDGAVARANHIQTAEFVITGGMQAAASALKGQPTGFITDAAYRILYAAAYDWKEDQIAQANAAAAQQTEYHFTTGQKQVNHMVAGWAQENGYDKETGLSRHLVGSGQERYDSARTEALIYLD
>NC_016582.1|WP_158104648.1|4405171_4405477_-|WXG100-family-type-VII-secretion-target
MSTPDGMLVDYESVLQLATQLRTAASNVRKEMQDIQGAVKKVTAGWEGEAHQAMLAAEKQFQARADHIQGLVTRVATLVESGKDAYHATDVKASKLFSVSY
>NC_016582.1|WP_014175981.1|4405565_4405970_-|hypothetical-protein
MSKQRVSDDAFRIFTNELDQSIQGFASNMKLMADILATVDSGWQGQGAGAFKKAQMDLEQDHDAVRRLVDGIREAVALTHRASGANDDDIASQLKGIDVNGAAAGGHITPGSSVGGLGAGTDAPIASYSKVDGF

Crispr_ID: NC_016582_9

• CRISPR_ID: NC_016582_9
• CRISPR_location: 4881346-4881413
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_9

Consensus_repeat	Method
GGACAGCGGGAACCCAGACAGGGGA	CRISPRCasFinder

spacers of NC_016582_9

>9.1|4881371|18|NC_016582|CRISPRCasFinder
ACTTGGACAGCCGGAACC

CRISPR arrays and Neighbor proteins around NC_016582_9

CRISPR arrays

The CRISPR arrays of NC_016582_9

>merge|NC_016582|9|4881346-4881413|CRISPRCasFinder
GGACAGCGGGAACCCAGACAGGGGAACTTGGACAGCCGGAACCCATACGCCGGAACCCACACATGGGA

>NC_016582|9|8|4881346-4881413|CRISPRCasFinder
GGACAGCGGGAACCCAGACAGGGGA	ACTTGGACAGCCGGAACC
CATACGCCGGAACCCACACATGGGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_043486768.1|4882528_4883911_+|CBS-domain-containing-protein	unknown	unknown	gnl|CDD|376177
NC_016582.1|WP_014176402.1|4894496_4897697_+|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl|CDD|223683
NC_016582.1|WP_043490173.1|4876150_4877236_-|threonine-synthase	unknown	unknown	gnl|CDD|236013
NC_016582.1|WP_014176387.1|4870814_4871909_-|LCP-family-protein	unknown	unknown	gnl|CDD|367673
NC_016582.1|WP_014176385.1|4869176_4870247_-|peptide-chain-release-factor-1	unknown	unknown	gnl|CDD|234801
NC_016582.1|WP_014176384.1|4868266_4869112_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	unknown	unknown	gnl|CDD|236467
NC_016582.1|WP_143675757.1|4884390_4885023_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014176399.1|4891406_4892630_+|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341131
NC_016582.1|WP_014176392.1|4878728_4880120_-|diaminopimelate-decarboxylase	unknown	unknown	gnl|CDD|273415
NC_016582.1|WP_106436366.1|4892637_4893879_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226984
NC_016582.1|WP_014176397.1|4887114_4889235_+|N-6-DNA-methylase	unknown	unknown	gnl|CDD|280533
NC_016582.1|WP_014176396.1|4885225_4886920_-|TIGR04141-family-sporadically-distributed-protein	unknown	unknown	gnl|CDD|275009
NC_016582.1|WP_043490175.1|4880139_4881165_-|hypothetical-protein	unknown	unknown	gnl|CDD|234964
NC_016582.1|WP_014176389.1|4874876_4875791_-|homoserine-kinase	unknown	unknown	gnl|CDD|234920
NC_016582.1|WP_014176398.1|4889313_4891410_+|SAM-dependent-DNA-methyltransferase	unknown	unknown	gnl|CDD|223363
NC_016582.1|WP_014176401.1|4893875_4894490_+|DUF4276-family-protein	unknown	unknown	gnl|CDD|379470
NC_016582.1|WP_014176386.1|4870422_4870647_-|50S-ribosomal-protein-L31	unknown	unknown	gnl|CDD|234576
NC_016582.1|WP_014176391.1|4877312_4878605_-|homoserine-dehydrogenase	unknown	unknown	gnl|CDD|235783
NC_016582.1|WP_014176388.1|4872225_4874442_-|transcription-termination-factor-Rho	unknown	unknown	gnl|CDD|237171
NC_016582.1|WP_014176394.1|4881478_4881898_-|response-regulator	unknown	unknown	gnl|CDD|381093

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_043486768.1|4882528_4883911_+|CBS-domain-containing-protein	gnl|CDD|376177	pfam18755, RAMA, Restriction Enzyme Adenine Methylase Associated. An alpha+beta fold domain associated with restriction enzymes across prokaryotes and fused to JAB deubiquitinases, and chromatin proteins in a wide range of eukaryotes. The domain is predicted to function as a modified-DNA reader domain.	3.11066e-23
NC_016582.1|WP_014176402.1|4894496_4897697_+|type-I-restriction-endonuclease-subunit-R	gnl|CDD|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	2.30736e-66
NC_016582.1|WP_043490173.1|4876150_4877236_-|threonine-synthase	gnl|CDD|236013	PRK07409, PRK07409, threonine synthase; Validated.	0
NC_016582.1|WP_014176387.1|4870814_4871909_-|LCP-family-protein	gnl|CDD|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	5.02119e-63
NC_016582.1|WP_014176385.1|4869176_4870247_-|peptide-chain-release-factor-1	gnl|CDD|234801	PRK00591, prfA, peptide chain release factor 1; Validated.	0
NC_016582.1|WP_014176384.1|4868266_4869112_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	gnl|CDD|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	4.99545e-103
NC_016582.1|WP_014176397.1|4887114_4889235_+|N-6-DNA-methylase	gnl|CDD|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	1.12051e-39
NC_016582.1|WP_014176399.1|4891406_4892630_+|restriction-endonuclease-subunit-S	gnl|CDD|341131	cd16961, RMtype1_S_TRD-CR_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR) and similar domains. The restriction-modification (RM) system S subunit generally consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This superfamily represents a single TRD-CR unit; in addition to type I TRD-CR units, it includes RMtype1_S_TRD-CR_like domains of various putative Helicobacter type II restriction enzymes and methyltransferases, such as Hci611ORFHP and HfeORF12890P, as well as TRD-CR-like sequence-recognition domains of the M subunit of putative type I DNA methyltransferase such as M2.CinURNWORF2828P and M.Mae7806ORF3969P.	2.39282e-27
NC_016582.1|WP_014176392.1|4878728_4880120_-|diaminopimelate-decarboxylase	gnl|CDD|273415	TIGR01048, Diaminopimelate_decarboxylase, diaminopimelate decarboxylase. This family consists of diaminopimelate decarboxylase, an enzyme which catalyzes the conversion of diaminopimelic acid into lysine during the last step of lysine biosynthesis. [Amino acid biosynthesis, Aspartate family].	1.28657e-166
NC_016582.1|WP_106436366.1|4892637_4893879_+|AAA-family-ATPase	gnl|CDD|226984	COG4637, COG4637, Predicted ATPase [General function prediction only].	1.05207e-27
NC_016582.1|WP_014176396.1|4885225_4886920_-|TIGR04141-family-sporadically-distributed-protein	gnl|CDD|275009	TIGR04141, conserved_hypothetical_protein, sporadically distributed protein, TIGR04141 family. This model describes a sporadically distributed conserved hypothetical protein in which complete members average over 500 amino acids in length, although matching sequences frequently are truncated or broken into tandem ORFs. Regular co-clustering with known markers of mobility (integrases, transposases, phage proteins, restriction enzymes, etc.) suggests this family also is part of the mobilome. The function is unknown.	9.90045e-168
NC_016582.1|WP_043490175.1|4880139_4881165_-|hypothetical-protein	gnl|CDD|234964	PRK01611, argS, arginyl-tRNA synthetase; Reviewed.	7.09475e-31
NC_016582.1|WP_014176389.1|4874876_4875791_-|homoserine-kinase	gnl|CDD|234920	PRK01212, PRK01212, homoserine kinase; Provisional.	1.06406e-103
NC_016582.1|WP_014176398.1|4889313_4891410_+|SAM-dependent-DNA-methyltransferase	gnl|CDD|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	1.56801e-77
NC_016582.1|WP_014176401.1|4893875_4894490_+|DUF4276-family-protein	gnl|CDD|379470	pfam14103, DUF4276, Domain of unknown function (DUF4276). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 190 and 224 amino acids in length. There is a single completely conserved residue E that may be functionally important.	4.46092e-08
NC_016582.1|WP_014176386.1|4870422_4870647_-|50S-ribosomal-protein-L31	gnl|CDD|234576	PRK00019, rpmE, 50S ribosomal protein L31; Reviewed.	4.03136e-39
NC_016582.1|WP_014176391.1|4877312_4878605_-|homoserine-dehydrogenase	gnl|CDD|235783	PRK06349, PRK06349, homoserine dehydrogenase; Provisional.	0
NC_016582.1|WP_014176388.1|4872225_4874442_-|transcription-termination-factor-Rho	gnl|CDD|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	0
NC_016582.1|WP_014176394.1|4881478_4881898_-|response-regulator	gnl|CDD|381093	cd17538, REC_D1_PleD-like, first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains. PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	5.85586e-30

Protein sequences

>NC_016582.1|WP_043490175.1|4880139_4881165_-|hypothetical-protein
MTPAQLSRTVLQTVRRAVEADELRVAVLPERVKVQAPPRAGCGDYATNVALQLAKLVKGDGGPAVALRVAEVLRRRLVVTPGIAGVEIAGPGFLNITVDSGGHAALVRGVLERGEDYGRSDALAGTLVRLAPAREVRGALVGAVVVRLVVVCGGECEVAEGGAVLAVRPAGISAEELLGLLGSDASRWALLRAAAHDLPDLDPGRLLAQRESNPLFRVRYAHSRVRALLRNGVDLGVDPDSSRSADSAYDHPTAVALISLLGDYPRLLESAARHRAPDRLARHLEATADAFFRFHDACPPLPRGEQKPLAAHRSRLALAEAAGTVLAGGLHLLGISAPEHL
>NC_016582.1|WP_014176392.1|4878728_4880120_-|diaminopimelate-decarboxylase
MSRSAHPAGPRHADVLPEGHYTAPPTDLNALDPRVWARTVGRDADGVVTVGGVDVKTLAEEFGTPGYFLDENDFRARCRAWREAFGADADVFYAGKAFLCRAVVRWLNEEGLNLDVCSAGELATALGAGMPAERIALHGNNKSEAEIRRAVEAGVGRIVLDSFQEIVRVAHIAERLGKRQRVQIRVTVGVEAHTHEFIATAHEDQKFGIPLAGGLAAEAVRRALKLDGLELIGVHSHIGSQIFDTSGFEVAAHRVVGLLKEIRDEHGIELPEIDLGGGLGIAYTSEDDPSEPHQIAKALRDIVHRECEAAGLEVPRLSVEPGRAIAGPTTFTLYEVGTVKELPALRTYVSVDGGMSDNIRTALYDAEYSVALVSRISTAEPMLSRVVGKHCESGDIVVRDAFLPADLAPGDLIAVPATGAYCRSMASNYNHALRPPVVAVKDGQAREIVRRETEEDLLRLDVG
>NC_016582.1|WP_014176391.1|4877312_4878605_-|homoserine-dehydrogenase
MMRTRPLKVALLGCGVVGSEVARIMTTHAADLTARIGAPVELAGIAVRRPNRVREGVPAELVTTDATALVKRGDIDVVVEVIGGIEPARSLISTAFEHGASVVSANKALVAQDGAALHAAALERGVDLYYEAAVAGAIPLVRPLRESLAGDKVNRVLGIVNGTTNFILDRMDTSGAGYSEALDEATALGYAEADPTADVEGFDAAAKAAILAGIAFHTRVTLDDVHREGITEVTASDIASAKRMGCTVKLLAICERAEDGRSVTARVHPAMIPLSHPLASVREAYNAVFVEAEAAGRLMFYGPGAGGLPTASAVLGDLVAACRNRLGQTTGPGESAYTRLPVSPMGDVITRYHISLDVADKPGVLAQVATVFSEHGVSIDTVRQQGKDGEASLVVVTHQASDAALTATVEALRRLDTVRDVASIMRVEGE
>NC_016582.1|WP_043490173.1|4876150_4877236_-|threonine-synthase
MSGTRRWQGWRGIIEEYRDRLPVSETTPVVTLREGGTPLVPAQVLSERTGCEVHLKVEGANPTGSFKDRGMTMAISMAKEAGAQAVICASTGNTSASAAAYAVRAGMVCAVLVPQGKIALGKMGQALVHGSKILQVDGNFDDCLELARGLSEKYPVALVNSVNPARIEGQKTASFEIVDMLGDAPDIHVLPVGNAGNITAYWKGYKEYATDGPLGAPASRTPRMWGFQASGAAPIVRGEPVRNPSTIATAIRIGNPASWAFAEQARDESGGLIDEVTDRQILAAYRLLASQEGVFVEPASAASVAGLLKAAEQGLVDPGQRIVCTVTGNGLKDPDWAVAGAPQPVTVPVDADTAAERLGLA
>NC_016582.1|WP_014176389.1|4874876_4875791_-|homoserine-kinase
MAGPAFRAAAVRVRVPATSANLGPGFDALGLALGLYDDVVVRVADSGLHVDIAGEGAETLPRDEDHLLVRSLRTAFDLLGGQPRGLEVVCANRIPHGRGLGSSSAAICAGIVAARAVTIGGAERLDDAALLELATEIEGHPDNVAACLLGGFTLAWMDAGAARAIRMDPSDSIVPVVFVPGRPVLTATARGLLPRNVPHVDAAANAGRAALLVEALTRRPELLLAATEDRLHQEYRAPAMPESVALVNRLRADGVPAVISGAGPTVLALVEDGAADKVARLAGEGWAANRLALDAGGASVLPLT
>NC_016582.1|WP_014176388.1|4872225_4874442_-|transcription-termination-factor-Rho
MSDTTDLMGVNASGTSDSGVGNAAPATDAPAAPATGAATGTAPRRRRSGTGLDAMVLAELQQLASSLGIRGTARMRKSQLIEVIKEKQGSGASAKSAEAAPAAAEGVTKPKRRTTSKARTGEDSEPAAAKTAATKADGAKDEAAAKAEKATAQQQIEIPGQPGEPAADEQPADGRRRRRATAPVTATTTDSTATATAVETKTETKAEAAKAATKPAALADAKAEAAVDTAEGKSAKGQDRAERAERGQKGDRRERGGQRERDGREGREGREGRDGREGRDGREGRDSRDRRGGKGEDGAAQSGGRQQRDSRGQGQQRPGADDMDDDFDGGRRGRRGRYRDRRGRRGREEFGNEPQVSEDDVLIPVAGILDILDNYAFIRTSGYLPGPNDVYVSLAQVRKNGLRKGDHVTGAVRQPREGERREKFNALVRLDSVNGMAPETGRGRPEFGKLTPLYPQDRLRLETEAGGLTTRIIDLVAPIGKGQRGLIVAPPKTGKTMIMQAIANAITRNSPECHLMVVLVDERPEEVTDMQRSVKGEVISSTFDRPAEDHTTVAELAIERAKRLVELGHDVVVLLDSITRLGRAYNLAAPASGRILSGGVDSTALYPPKKFFGAARNIEDGGSLTILATALVETGSRMDEVIFEEFKGTGNMELRLDRKLADKRIFPAVDVDASSTRKEEILLAPEELSIVWKLRRVLHALDSQQAIELLLDKMKQTKSNAEFLMQIAKTTPTPGNGD
>NC_016582.1|WP_014176387.1|4870814_4871909_-|LCP-family-protein
MAKHRNTTPQDSAPAPRSGRRKALMGTVWTLATVLVLGGAGAGYVYYKLNGNITSVNINGALGSDRPKNVDNGSMDILVLGSDSRAGQNAKYGTDEGTSRSDTAMVVHVYKGRKKAGVVSIPRDTLIRRPVCTKDGKTVPAQRLAMFNSAYEVGGPACAVKTVESMTGIRMDHYLEVDFSGFKHLIDQLGGVDITTTQPIHDAKSHLDLEPGQHTLNGEQSLGLVRTRHAVGDGSDLGRIKLQQAFIKALLDQIKSVDLFSSPKKLYDLADTSTKALTTDSELASVNKLLGFAKGLKGIGSKDMHMVTLPVQYDPNNPNRVLPIDTKAREVWQALRWDKPIPASATKGSAGDATGDAGKVVRNP
>NC_016582.1|WP_014176386.1|4870422_4870647_-|50S-ribosomal-protein-L31
MKRDIHPEYVETQVSCTCGASFTTRSTVAGGTIRADICSECHPFYTGKQKILDTGGRVARFEARFGKNAGSAKK
>NC_016582.1|WP_014176385.1|4869176_4870247_-|peptide-chain-release-factor-1
MFEAVEELIGEHADLEKRLADPAVHADQREATRLGKRYAELTPIVGTYRSWKQTGEDIETARELAQLDADFADEVKELEARREELTDRLRLLLVPRDPSDDKDVILEVKAGEGGEESALFAGDLLRMYLRYAERVGWKTEIIDANESDLGGYKDVQVAVKAKSNAEPGQGVWARLKYEGGVHRVQRVPATESQGRIHTSAAGVLVTPEAEEVEVEISQNDLRIDVYRSSGPGGQSVNTTDSAVRITHLPTGIVVSCQNEKSQLQNKEQALRILRSRLLAAAQEEAEREASDARRSQVRTVDRSERIRTYNFPENRISDHRVGFKAYNLDQVLDGELDPVIQACVDADAAAKLAAAQ
>NC_016582.1|WP_014176384.1|4868266_4869112_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase
MNVLLAEVAQATQRLADAGVPSPRFDAEELAAFVHGVKRGELHGVADADFDARYWEAVARREAREPLQHITGRAFFRYLELQVGPGVFVPRPETESVVGWAIDAVRAMDVVEPLIVDLCSGSGAIALALAQEVPRSRVHAVELDEGALRWARKNVEGSRVVLHHGDALTALPELDGQVDLVISNPPYIPLTEWEYVAPEARDHDPQLALFSGEDGLDVIRGLERTAHRLLRHGGVVVIEHADTQGGQVPWIFTEERGWADAADHPDLNKRPRFATARKAMP
>NC_016582.1|WP_014176394.1|4881478_4881898_-|response-regulator
MSGRVLVVDDNKVIRQLIRVNLELEGFEVVTAADGAECLEIVHQVRPDVITLDVVMPRLDGLHTASRLRADARTCHVPVAIISACTQYEVDSGRAAGVDAFLAKPFEPAALVKLVRRLMTPGAAAAAPGDAEPVVGPTG
>NC_016582.1|WP_043486768.1|4882528_4883911_+|CBS-domain-containing-protein
MGRESYLLEGRRVTVGDLLEAGYLNAGAKLTFERPRRGEKHHAELAANGKVQLSDGQLFRSPSRAAIAAVGGGSFDGWHAWTLDDGRTLDQLRQQLLDEAAQQASETPSEAEAGNELFTPAERHEQLKRARELVDTGKPPTLTVREFIGWWGALRRGYLITKQIEAELANHSLTTLPNFEKVHFDSTVQLVTTAQKEEDGTDEDTPPSPLTVDKSALDDEDEPETGLTVGNLPSALSEVISVPPDATYEQAITLMVINDYSQIPVISGRNLRGAVTWKSIARARHAKPDATFSDAIIPAREISYDHDLIDILPALAEFEFVLVKDQTQKIAGIVTASDVAAAYGSLASPFFLIGELDQRLRRVIMRNFELSEVQNHCDPQGQRGVSSFDDLSIGDYQRVLENPTLWDQLGWPLDRKVFGKRLDEIRIIRNDLMHFNPDPLPDDAIQKIRNMINLLREYGA
>NC_016582.1|WP_143675757.1|4884390_4885023_-|hypothetical-protein
MPDWTDLISQALSALLGTVVGGAITVFVARWQTAKTINAQTQLAAEQHAASVQLARAGRERENSAVAAKQLLEHLADLYAWLPSLPDVSLENPRLSEHARARCTEAMESVRCGMFTELFSITDAGMRERYRALVRLVYDAGWRGAGGQHPEQLVRDVRNYLRYVQVSLGSVIDGKPLPVREEPPALDRDSPAVWLPSSSSAIWGDLADGS
>NC_016582.1|WP_014176396.1|4885225_4886920_-|TIGR04141-family-sporadically-distributed-protein
MATSTSGTSKRTLYRLTGVAPTVDAMFGVLDPTRLDAVGAELDFPGEWLGVPALLVTGSFAQPVASWCGEINRTTGCEVSRPVNRSAGLLMLAVDGEVYAIGYDQGFRLVPDRVKDRRFGLGFVIRRVDPAQIRDLVSHTPGGGRTDITLVPGGAPVWSLGVQEHAQIVRRLGGRLDGIELTIAQDDRTKISSVEGGTGLRMRLGIDAVDLVADIRAIARVLRDQAPAPELEFVEHIVPVKGADLVTRLEERLDDMLGEVPDGRIAVAVPSDHWDDYGAAQAFATKVHSPEARLTDDFSLEYVLNRARVQRAGTRFTALRDGTVTLYAHTRAEKGDVIWASSVLRWIEAQVTLGARRFFLLDGQWHEIGEAYLEAIRSQVERLITDTPSVDLPAWVLGDKERDYNESVPDLRPGYVCFDRDNVRTALHRGNGVEICDLLSPDDVLVMVKRAKGSDALSHLFGQAVVAVQTLLHSPEAGDGFARKVAAARPGRPLPEGFRPSRVVFAILLKDGAALTADTLFPFSQVTLVQTAKILEAWRVEVEVIGIQATAAPPSRAGIRHLAA
>NC_016582.1|WP_014176397.1|4887114_4889235_+|N-6-DNA-methylase
MNQQASAHVTAADISRLAGVTRATVSNWRRRHPDFPAPAGGTDTSPTYDLDAVRAWLSARGQLPEDTPADRLRTALRTHPGDGVLALHLLPVVLAAARLDRREREALPELRDDALLRWVRSAADVGAQDIPGTEDAAYAPEAAEPLRALLRCVVTDGAEAATDVLAERLLEDTGGTGTYLTPRPLAALMARLLTESAGAFPASVLDPACGTGSLLAAAASAGASELHGQDVLVAQAAQAAVRLRLNAPEAAISVHTGDSLRSDAFKGLTADAVLCNPPYGVRDWGHDDLAYDQRWAYGVPPKGEPELAWVQHCLAHLTPRGRAVLLMPPAVAERTAGRRIRAQLVRDGALRAVVSLPQGAATPLHIGLHLWVLERPDPQAEAPGTVLLVDAAAENRDLDWVAVNDTVLSAWRAYLADQGDFTGAPGTAAAMPVTDLLDEAVDLTPARRIRTASRQALRPALLARQASELYDQLRQGATDLVDLSTDGDWPPADDRPRDWRTATVADLLRGGALSLLHTAPPGRRTRSGQPQPQPEAEPGPRPALTAADVFENRPASGTEADLPTGVTLPLVEGSDVLLTEILRVGRTAMARVVEPGEAGCFLGPHLLLFRPDRRRLDPWFLAGFLAAEQNVNAAATGTSLVRVDPRRLRVPLLPLAEQQRYGAAFRRLHELRTAARRAEQAAEDVTRLLGTGLTDGALLPDGHGSA
>NC_016582.1|WP_014176398.1|4889313_4891410_+|SAM-dependent-DNA-methyltransferase
MNSSKHTELANHAWSVADLLRGDYKQSDYGKVILPFTVLRRLECVLAPTKDKVLEVAARYQGQDINPDRFLRIASGHSFYNTSTYTLKAIAGDASHVAKYLNEYYGAFSPNAREVLERYDFAQQIKRLETANLLYQVVGRFADLDLRPVKRDADGKVVLGEDGKPVEIVSNHQMGYIFEELIRRFAEQSNETAGEHFTPREVIRLMVNLLVAPDSDALALPGTVRTVMDPACGTGGMLSAAEERITALNPDATVKVFGQELNPESWAICRSDMMIKGQDPENIKFGNSFSQDGFSRDDSRRDKNTPTTFDYLLANPPFGVEWKKVKDAVEDEHERLGESGRFGAGLPRINDGSLLFLQHMISKMKPVDASGAGGSRIAIVFNGSPLFTGAAESGESRIRQWILEHDWLEGIVALPDQLFYNTGISTYFWVLSNRKARDRRGKVVLLDARDYWQKMRKSLGDKRKELSDQHISEITRLYTDALAVVDAAERGSGHDLADRAGKIKVFRNEDFGYRRITVERPLKLRFEVTEETLSAITASKPIARATDAEAFVAALRPLVGKSWTTKSDAWIDLKDAVVAAGLLWPTGAPFSKALREAVGVRDPEGEEQKAKGQPEPDPELRDYENVPLGEDVEEYLRREVLPHVPDAWIDHTKTKVGYEIPVTRHFYVYKPPRPLAEIDADLKALESEIQALLGEVTK
>NC_016582.1|WP_014176399.1|4891406_4892630_+|restriction-endonuclease-subunit-S
MSWATIPLKFLATSAQTGPFGSQLHSDQYITDGIPVINPSNIKDGKLVPDRNSTVSVETAARLAVHRLLSGDIIFARRGELGRSAIVTKSAEGWLCGTGSIRVRINQNRLDYRFAGYALQNLQTYSYFQKQSVGSTMENLNTEIVLGLPVALPTLANQRRIADFLDSETEKIDAFTHKTRRLLHLLDEKIASRILGHVGASQLNDIHSGSPVREINKLLTKVVRPPIADGEVITAYRDGQVTARSLRRAEGYTVSATTEAQGQRVDRGDIVIHGLDGFAGAIGTSEAAGNCSPVYHVCIPRNGGDSLFYGRLLRILALSEYLGPFATSTRERAVDFRNWNLFGRIPIPDVSFKEQQEIGEWIKSARPLRIAVDRSNALAIERRQALITAAVTGQIDVSTASGRGIEE
>NC_016582.1|WP_106436366.1|4892637_4893879_+|AAA-family-ATPase
MSPAAPHRPMPFITRVQVDNYKSIAHCDVTLGRFTVLLGLNAAGKSNFLDALRFVRDALVNGPAEAVAARGGWEEVLRRVPEPATSCTIGLEFHLPDITPDAKPWVGRYEITLAQQTVPETGRDAGPGVRIQRELCEMRRLGVGGRANAEHFMMRDRTGRGRRQKRLQLSHLSEGEPFADLFAALTEMFFYSPDLANLRKASPNTPTAGALGEDGGDLGPALAALEEQERERVSQYLGVIVPGVVEVGPTDPSADYIAARINFATDGETEPHVFRAESMSEGTIRAIGLLTALFQPDAREGWIPLIAVEEPELALHPLAAGALYDALTEASEYVQVLATTQSAELFDRKEADLSAIRVVAAEHGVTVIGEVDPVSRSIVADGLATTAELLRSDQLRPVVEAPAEPDEQPEGEE
>NC_016582.1|WP_014176401.1|4893875_4894490_+|DUF4276-family-protein
MNHPRVTIASVVEGEGEISALPVLLRRLMYEVQIWDADIQPPFLVDRGRLVRPGGLEAAVEAQARRVPADHPGGILVVIDADDDCPASLGPSLLARAEAARPDRRTAVVLANREFEAWFLASAPSLGGRAGLAERLEVPANSETLRDCKGWLTHHRRDGVRYRPRVDQAALTDVINLDLDRANSSSFDKFCRDITYLVTGKRGE
>NC_016582.1|WP_014176402.1|4894496_4897697_+|type-I-restriction-endonuclease-subunit-R
MPVHDEAAFGNAIVAALLEHGWSEGSRSHYQPHLGLDTAQLFEFIGKTQADEWAELIALYGGDPNTAQAGFAKRVDQAIANDDVLDVLRKGVKDHGVLIRLAYFKPSLVASDAVLNDYRENRLTFVKELEYAAKQADKGKRLDLTLFLNGIPLATAELKNALTRQGVEAAKDQYRTDRDSTELIFTRRVIANFAIDTDLVFVAPELRGKPTRFLPFNTGSEGPGKPGGAGNPAPTVPGTYATSYLWEQIWERDTWLDLIERFVHLSKEKGPDGRTRKKLIFPRYHQWDIVKKLAGHAACHGAGHNYLGMASAGSGKSNTIGWLAHRLSSLHTPTDPAEIDPDALAAGLKPGAPVFDKVVIITDRRNLDAQLRETVGSFEKTAGLVVKIDEKHGAKSDQLAKALSRETGKIITVTLHTFPALIDYLRRNPTEIQGHNFAIIVDEAHSSQSGDAATAVRAALRDLGLDSDSDEAGATELEAEAATDAKLRRKAIQRSKASNLSYFAFTATPKAKTLELFGTLESVNGKPTYVPFHTYSMRQAIEEGFILDPLRTYVTYNTYWKLVNKNPDEREVDPSKANPLLARYALTHDSTVTQQAQVIVEHFRTHTAGRLGGRAKAMVVTASRHSAVQMARAIRKYIDDRAYADPGVLVAFSGSLTYDGKETTEPKENGGLAESALPKAFAYTRKDDKAVRTGGKATQREYRILVVAEKYQTGFDQPLLTTMYVNKKLAGISAVQTLSRLNRTADRKSQTDLAVLDFVNDTEDIKASFVPYFEEANTLPSDPNLLYTAQSRVMQPDILVEDEMREFASAYLAAEEKAAGSVARWEKLHAELYRHLGPAVERFTELLDRKDEAGDPDEEGAEAAEQFRADLNDYVRKYGFLSQIVPYRDADLECLYLYGRHLLNRLPRRGDGGVDIGDVDLSHLRIQKTGEYDLALTSEGAAELRGFGEGAGGAKEQEKSLLSELIEKFNDKFGTDFTEQDVLTPFDEAKADPKVRAAAVNDEENFGLVFDEVFEDKMAEHIDTIADMGRQYFSHDDSFKQSLNQSARRAAWRMIRREENIDDEAA

Crispr_ID: NC_016582_10

• CRISPR_ID: NC_016582_10
• CRISPR_location: 5802518-5802655
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_10

Consensus_repeat	Method
CGGTGATGGCGTCCATGGTGAGGGACGGGCCTTTCAGAGGGAGACGCTCAGCG	CRISPRCasFinder

spacers of NC_016582_10

>10.1|5802571|32|NC_016582|CRISPRCasFinder
CGCCGGGCGCTCTGGGTTGCGAAGATGCCCGT

CRISPR arrays and Neighbor proteins around NC_016582_10

CRISPR arrays

The CRISPR arrays of NC_016582_10

>merge|NC_016582|10|5802518-5802655|CRISPRCasFinder
CGGTGATGGCGTCCATGGTGAGGGACGGGCCTTTCAGAGGGAGACGCTCAGCGCGCCGGGCGCTCTGGGTTGCGAAGATGCCCGTCGGTGATGGCGTCCATGGTGAGGGACGGGCCTTTCAGAGGGAGACGCTCAGCG

>NC_016582|10|9|5802518-5802655|CRISPRCasFinder
CGGTGATGGCGTCCATGGTGAGGGACGGGCCTTTCAGAGGGAGACGCTCAGCG	CGCCGGGCGCTCTGGGTTGCGAAGATGCCCGT
CGGTGATGGCGTCCATGGTGAGGGACGGGCCTTTCAGAGGGAGACGCTCAGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_055414218.1|5810250_5811285_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_078610495.1|5795493_5796489_+|VanZ-family-protein	unknown	unknown	gnl|CDD|377417
NC_016582.1|WP_014177238.1|5796595_5797762_-|adenosine-deaminase	unknown	unknown	gnl|CDD|236480
NC_016582.1|WP_078610918.1|5805700_5807347_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|226364
NC_016582.1|WP_014177235.1|5794757_5795357_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014177253.1|5815492_5816467_+|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|366154
NC_016582.1|WP_014177248.1|5808672_5810001_-|amidohydrolase	unknown	unknown	gnl|CDD|349936
NC_016582.1|WP_078610496.1|5797888_5798653_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|224423
NC_016582.1|WP_078610917.1|5793216_5794761_+|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_016582.1|WP_043487045.1|5813839_5815195_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014177233.1|5792339_5793017_+|two-component-system-response-regulator-AfsQ1	unknown	unknown	gnl|CDD|223816
NC_016582.1|WP_014177251.1|5812389_5813652_-|acylneuraminate-cytidylyltransferase	unknown	unknown	gnl|CDD|133006
NC_016582.1|WP_014177231.1|5790436_5791099_+|ATP-binding-protein	unknown	unknown	gnl|CDD|223645
NC_016582.1|WP_014177247.1|5807468_5808506_-|BMP-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380577
NC_016582.1|WP_014177244.1|5803068_5804331_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224005
NC_016582.1|WP_055414217.1|5798672_5799593_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176125
NC_016582.1|WP_078610494.1|5791308_5792136_-|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|132028
NC_016582.1|WP_106436635.1|5804327_5805677_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|226962
NC_016582.1|WP_078610498.1|5799751_5801125_+|MFS-transporter	unknown	unknown	gnl|CDD|340882
NC_016582.1|WP_014177250.1|5811453_5812389_-|N-acetylneuraminate-synthase-family-protein	unknown	unknown	gnl|CDD|376990

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_078610495.1|5795493_5796489_+|VanZ-family-protein	gnl|CDD|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	5.21623e-17
NC_016582.1|WP_014177238.1|5796595_5797762_-|adenosine-deaminase	gnl|CDD|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	1.25171e-153
NC_016582.1|WP_078610918.1|5805700_5807347_-|ABC-transporter-ATP-binding-protein	gnl|CDD|226364	COG3845, COG3845, ABC-type uncharacterized transport systems, ATPase components [General function prediction only].	0
NC_016582.1|WP_078610494.1|5791308_5792136_-|SigE-family-RNA-polymerase-sigma-factor	gnl|CDD|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	5.15045e-65
NC_016582.1|WP_014177253.1|5815492_5816467_+|glycosyltransferase-family-2-protein	gnl|CDD|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	5.44955e-35
NC_016582.1|WP_014177248.1|5808672_5810001_-|amidohydrolase	gnl|CDD|349936	cd08014, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, uncharacterized subfamily of uncharacterized bacterial proteins predicted as putative amidohydrolases. These are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	2.88398e-177
NC_016582.1|WP_078610496.1|5797888_5798653_+|alpha/beta-fold-hydrolase	gnl|CDD|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	7.18739e-06
NC_016582.1|WP_078610917.1|5793216_5794761_+|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.28404e-56
NC_016582.1|WP_014177233.1|5792339_5793017_+|two-component-system-response-regulator-AfsQ1	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.20507e-81
NC_016582.1|WP_014177251.1|5812389_5813652_-|acylneuraminate-cytidylyltransferase	gnl|CDD|133006	cd02513, CMP-NeuAc_Synthase, CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety. CMP-N-acetylneuraminic acid synthetase (CMP-NeuAc synthetase) or acylneuraminate cytidylyltransferase catalyzes the transfer the CMP moiety of CTP to the anomeric hydroxyl group of NeuAc in the presence of Mg++. It is the second to last step in the sialylation of the oligosaccharide component of glycoconjugates by providing the activated sugar-nucleotide cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), the substrate for sialyltransferases. Eukaryotic CMP-NeuAc synthetases are predominantly located in the nucleus. The activated CMP-Neu5Ac diffuses from the nucleus into the cytoplasm.	1.1284e-74
NC_016582.1|WP_014177231.1|5790436_5791099_+|ATP-binding-protein	gnl|CDD|223645	COG0572, Udk, Uridine kinase [Nucleotide transport and metabolism].	8.53365e-18
NC_016582.1|WP_014177247.1|5807468_5808506_-|BMP-family-ABC-transporter-substrate-binding-protein	gnl|CDD|380577	cd06354, PBP1_PrnA-like, periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. The PnrA lipoprotein, also known as Tp0319 or TmpC, represents a novel family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC) transport system (pnrABCDE). It shows a striking structural similarity to another basic membrane lipoprotein Med which regulates the competence transcription factor gene, comK, in Bacillus subtilis. The members of PnrA-like subgroup are likely to have similar nucleoside-binding functions and a similar type 1 periplasmic sugar-binding protein-like fold.	9.49055e-95
NC_016582.1|WP_014177244.1|5803068_5804331_-|ABC-transporter-permease	gnl|CDD|224005	COG1079, COG1079, Uncharacterized ABC-type transport system, permease component [General function prediction only].	4.06354e-76
NC_016582.1|WP_055414217.1|5798672_5799593_-|LysR-family-transcriptional-regulator	gnl|CDD|176125	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold. GltC, a member of the LysR family of bacterial transcriptional factors, activates the expression of gltA gene of glutamate synthase operon and is essential for cell growth in the absence of glutamate. Glutamate synthase is a heterodimeric protein that encoded by gltA and gltB, whose expression is subject to nutritional regulation. GltC also negatively auto-regulates its own expression. This substrate-binding domain has strong homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.44568e-82
NC_016582.1|WP_106436635.1|5804327_5805677_-|ABC-transporter-permease	gnl|CDD|226962	COG4603, COG4603, ABC-type uncharacterized transport system, permease component [General function prediction only].	4.56419e-74
NC_016582.1|WP_078610498.1|5799751_5801125_+|MFS-transporter	gnl|CDD|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.53869e-72
NC_016582.1|WP_014177250.1|5811453_5812389_-|N-acetylneuraminate-synthase-family-protein	gnl|CDD|376990	pfam03102, NeuB, NeuB family. NeuB is the prokaryotic N-acetylneuraminic acid (Neu5Ac) synthase. It catalyzes the direct formation of Neu5Ac (the most common sialic acid) by condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine (ManNAc). This reaction has only been observed in prokaryotes; eukaryotes synthesize the 9-phosphate form, Neu5Ac-9-P, and utilize ManNAc-6-P instead of ManNAc. Such eukaryotic enzymes are not present in this family. This family also contains SpsE spore coat polysaccharide biosynthesis proteins.	1.05556e-116

Protein sequences

>NC_016582.1|WP_078610498.1|5799751_5801125_+|MFS-transporter
MPPADTEASTGTPVDASVKTAPAQTPAQMTPDRMSPGDPGFGRMRLALFAAGLATFALLFSTQALLPAISADLDVQPDQASWTVSAATLALALAVLPLSALSERFGRRAMMTGSLAVAVAVGLAVPFAPDLGWLIALRAVQGAAIAGIPASAMAYLSEEVRPSSLIGTIGLFVAGNSFGGMTGRLLTGWVADGWGWRVSLATVGVLSLVCAIAFRLLLPKARHFTPSAVSPRALARTCGGHLSDPLLRRLYAIGALFMTVFGGVYTVIGYRLVAEPFNLSQSLVGSIFLIYLVGTASSAAAGKLVGRLGRRGALYVAVTTTTAGLLLSLGDSLVAVVLGLVLITAGFFAGHAVASSSVSRAAKTGRAQASALYQTAYYVGSSVGGTLGALAFHAAGWSGTVVLGLVAVAGAAAITLYATRKALAERRAEIVARSAQQSERASSNETTQGMRRLAAQA
>NC_016582.1|WP_055414217.1|5798672_5799593_-|LysR-family-transcriptional-regulator
MAEFEADSWAASLTPRLVQFAAVARHEHVTRAAQWLGVPQSTLSRAMVRLEADLGVALFARRGRTVALTPAGRTFLRAVERALTEVERAAETVRADADPAAGKIAFGFLHTLGPETVPGLIRAFRVDHPRVRFQLVQSYGEAMIERMRTGDLDLCLTSPVPEAPDLVARRLDEQRLRLVVPDDHRLADRKRIRLAEAATELFVTLEPGYGLRRITDALCAEAGFKPKIAFEGEEAETLRGLVAAGFGVALLPPPAVPRPGVAELTVTAPRAVREIGVAWLDGHPDTAPVAAFKRFLLSRRGQLLPR
>NC_016582.1|WP_078610496.1|5797888_5798653_+|alpha/beta-fold-hydrolase
MAQQALPERGARLGRPKGAAAAQETVHGVVLLLPGGPETGTGRPSRLSVAAVLPLARRLVRAGRAEGLTAHVVHYRHRGWNDTAADPAADAGWAVDEVIRRYGDVPVCLVGHGMGARAALRAAGHDAVVSVVALAPWLPPAESALEPEPVKQLVGRQVLIAHGTNDQRVDPELSYRLAERAKKANRDVCRFEVHADGHGMHHHRSEVQALAADFLLGSLFDHGFSRPVEDALAAPPPLGLRMPLAAGFGSTLPG
>NC_016582.1|WP_014177238.1|5796595_5797762_-|adenosine-deaminase
MTSEYQDRPTPEQIRRAPKVLLHDHLDGGLRPATVVDLALETGYDGLPKSDPAELGRWFREAADSGSLELYLETFAHTCAVMQTRDALFRVAAECAEDLAEDGVVYAEVRYAPEQHLTRGLTLEQVVEAVNEGFREGERRAREKGLRIRVGALLTAMRHAARALEIAELANSYRDHGVVGFDIAGAEAGYPPTRHLDAFEYLKRENNHFTIHAGEAFGLPSIWQALQWCGADRLGHGVRIIDDIEVADDGSVTLGRLASYVRDKRIPLELCPTSNLQTGAARSYAEHPIGLLRRLQFRATVNTDNRLMSGASMSDEFEHLVSTFHYTLDDMQWFTVNAMKSAFIPFDERLAMINDVIKPGYAELKSEWLFRQMASASPLTRWSHVEGG
>NC_016582.1|WP_078610495.1|5795493_5796489_+|VanZ-family-protein
MQGHGSGRRAAFRFRAAGFVLLAAHLAYVCWLTLRPLSAPWVTAVTLEPLATIRADLALGPWEATRSIGGGLLLLAPLGVLLPLAGGRVTVYPLASFVRTVFTGAMVSLTMALVHSELTGQIMNVDTVLLNTAGVALAHLAVVPATRSWLRRRTDRRRAAALSPSPGTRATRAAKGNGPGAAPRPWPVPSTASGSHRRRRTMRQHTVGPAHPARVCGPHCPTLRRSAQHRQTAGLQGVGGEGEVVQQGLVGAGLTRPRGLGLGPGCGCGPLPDGRLRLPGAHSGACGPDRSVAGRSRGAASGNDGDRTEGNGAEGLDGSLLHQKSVLETGA
>NC_016582.1|WP_014177235.1|5794757_5795357_+|hypothetical-protein
MRRRAAGALLGAVALLASGCGIRGTSVPVDAGPAPSRASCQAPEPGRSAEGAGRVTVRIYLICNSRILSVSRSARLTDEKTPEPLQVARALLEQLQDPPTRAEEEAGFSTAVEDWVRISGPAKDDPDGALRLNRLPEELQSYALAQIVCTFTETTVADSRHRVVLGGPDADRDPLRRYECTGEMRRHPEIAVTSGVLVS
>NC_016582.1|WP_078610917.1|5793216_5794761_+|HAMP-domain-containing-histidine-kinase
MLVFGLVALAAAVSASAIAYWLNRDAVLTRTQDAALDDFSKSLKEATDPLPAVPTCPELQDAADRMADNSQKYEVLLIARTEGGGPCTAASADDLLTLKTVPETLRSAVDKKRAVAGSNTSPYHLYWQRITLKGTPYLIAGARVNGGGPTGYMLKSLETERQDLNSLAWSLGIATALALIGSALLAQAAAATVLRPVQRLGEAAHRLGEGHLDTRLEVSGTDELANLSRTFNRAAERLEKRVEELSAREASSRRFVADMSHELRTPLTAITAVTEVLEEETDALDPMIAPAVQLVVSETRRLNDLVENLMEVTRFDAGTARLVLDDVDVADQVTACIDARAWLDAVELDAERGIMARLDPRRLDVILANLIGNALKHGGSPVRVSVRPEDDDLLIRVRDHGPGIPEDVLPHVFDRFYKASASRPRSEGSGLGLSIALENAHIHGGEITADNHPDGGAVFTLRLPMDASRLSEPDQDGGQGSGPGGGQAGGEGGDRQGGQGGQGGQGGPDEGSER
>NC_016582.1|WP_014177233.1|5792339_5793017_+|two-component-system-response-regulator-AfsQ1
MPFLLLIEDDDAIRTALELSLSRQGHRVATAATGEDGLKLLREQRPDLIVLDVMLPGIDGFEVCRRIRRTDQLPIILLTARSDDIDVVVGLESGADDYVVKPVQGRVLDARIRAVLRRGEREANDSASFGSLVIDRAAMTVTKNGQDLQLTPTELRLLLELSRRPGQALSRQQLLRLVWEHDYLGDSRLVDACVQRLRAKVEDVPSSPTLIRTVRGVGYRLDAPQ
>NC_016582.1|WP_078610494.1|5791308_5792136_-|SigE-family-RNA-polymerase-sigma-factor
MNTLHFNNASAVIRTRLHDAGRSNEKSGAVSGRGCARGAGRQRPPYVVAIDAYTGAQGGNTGPGGPAEPAGSKEEGGFADQGGRGGSRGSSYGEASGERCEASEVEFTAYVQERRASLYATAYHLTGDRFEAEDLLQSALFSTYRAWDRISDKAAVGGYLRRTMTNLHISAWRRRKLNEYPTEELPETAGDHDAMRGTELRAVLWQALARLPELQRTMLVLRYYEGRTDPEIADILNISVGTVKSGIWRSLRRLREDEALSFGRDEEESFGELVA
>NC_016582.1|WP_014177231.1|5790436_5791099_+|ATP-binding-protein
MTIPPIPARVVLLSGPSGSGKSSLAARTGLPVLNLDDFYKEGDDPSLPQLPGGAGADWDSPLSWDADAAVAAVEALCRTSRTTVPVYDIATSARVGAEPLDIGRSPLFIAEGIFAADIIGRCRALGVLADALCLRGRPSTTFRRRLLRDLREGRKSAPYLLRRGWRLMRAERGIVARQTALGAYPCGKDMAMGRIAAAAASGRACSSPRTAEPASPSRTS
>NC_016582.1|WP_014177244.1|5803068_5804331_-|ABC-transporter-permease
MSTATTTTATDKPQPRKPVRQKLSLPVVLLIVAGALVLVSVVRLITGADDITSVGQVSGALELAIPIGLAGLGGLWAERAGVVNIGLEGMMILGTWLGAWAGYQWGPWVGVLFGILGGAIGGLLHAVITVTFGVNHIVSGVAINILAVGATRYLSNFTFLESSGSARKSPSIDPITQITVPGLSDAMKTLNGKHWFLVSDLAGLVGGVVTELSLLTVVALLLIPVTWWVLWRTAFGLRLRSCGENPVAAESLGVNVYRYKYLAVIISGGFAGLGGVFLAEVASNLYQEGQTGNRGYIGLAAMIFGNWMPGGLAMGAGLFGYTDSLNLRSGGTNVHALLLFLVAVLALVALWQLYRKKYLAAAIGAAFSALLLVWYSLTKEVPSQFVTAAPYIATLLVLALSAQRLRAPKAVGLPYHKGGG
>NC_016582.1|WP_106436635.1|5804327_5805677_-|ABC-transporter-permease
MNGDAKNGGSAGTTGDAPDKSGDGLNESGRTPTKSGSPADSPADSPAKSGSPAGSPADSPAKTSSAAGSAAKSGGSAGKRFSRDRLLLAVAGPVLALVVAVLLTSGVLLASGKSPFEPYQLMLEYAGNADIQVLIVNQASSYYLAALAVAIGFRMNLFNIGVDGQYRVAAMAAALVGANVDLPGPLSIALIVIVAMLVGAFWAGIAGILKTTRGVSEVVSTIMLNAIATSLIAYLILPEQFGVQPKGSNNLTTGDLPESSWFPGLHVSDVAGDIYGFVFVAIGCGVAYSLVLGRTRFGFDLRATGASESAAAASGVDAKRMVLTSMLISGAVAGLAGMPVLLGDSHTYSLNFQTGIGFTGITIALLGRNNAVGIAFGALLIAFLDKASQTLDYNGYEKEIATIMQGLIVISVVVSYETVRRYALRRQQRKVGEELAAAARTTTREEVPA
>NC_016582.1|WP_078610918.1|5805700_5807347_-|ABC-transporter-ATP-binding-protein
MAAPHHATPRHAPPPRLLLRGECAINASSSPPAVELSGITKRFPGVVANHDIHIAVRKGTVHAIVGENGAGKSTLMKTLYGMHKPDEGTIAVDGEEVSFHSPADAIARGLGMVHQHFMLADNLTVLENVVLGAEKLYGIGAKARAKIKEISDAYTLGVRPDVLVEDLGVADRQRVEILKVLYRGARTLILDEPTAVLVPQEVEALFDNLRELKAEGLTVIFISHKLGEVLSVADDITVIRRGTTVGSVVPSEVTARQLAEMMVGSELPSPETRESTVTEVPMLQVERVTLTTQNAEDGARTVLDDITFTIRKGEVLGLAGVEGNGQTELIDALIGTRKPDDGTILLGEEDITGWPTRRRREGGVGYIPEDRHRHGLLLEAPLWENRILGHVTERPNTKGKGGFWLDLKGARADTERIVAEYDVRTPGIEVTAASLSGGNQQKLIVGREMSHRPRLLIAAHPTRGVDVGAQAQIWDQIREARREGLAVLLISADLDELIGLSDTLRVIYRGRLVADADPATITPEELGSAMTGAATGHLEHPAEEGAAR
>NC_016582.1|WP_014177247.1|5807468_5808506_-|BMP-family-ABC-transporter-substrate-binding-protein
MRRVSSIAVAGIGIAALAFTTTACGGSSSDSKKDKGVAIAYDVGGRGDQSFNDAAYAGFVKAKKELGVKGDDIEPSEGESDADKVQRLTELAREGHNPVIAVGFVYAPAVKEVAKKYPKITFGLVDDDTVHMKNVVNMVFNEEQGSYLAGVAAALTTKSKTVGFVGGVENPLIKKFEAGYVQGVHDTDKSVKVKVQYLTQPPDYSGFKKPDSGKDTANGQLDGGADVIYQAAGDSGSGVIEAAATRGKWAIGVDSDQYTQKGLAKFKSKILASATKAVDEAVFNLVKSVKDGKPESGTVRYGLKTGGVGLADSNPAYQKMTKVVEAVETAKKKIISGEIKVKTTP
>NC_016582.1|WP_014177248.1|5808672_5810001_-|amidohydrolase
MSPETDSVTAEAEAVAAQAQALAPETVPADALALPGRLPEELRTELIAFRRDIHMHPELGNREFRTTAAIKARLEQAGLEPRVLPGGTGLICDIGTDGGTDGGTAIGTDGGAGAGTGDAAALPMLALRADIDALPIPDTKSVPYRSTVPDRAHACGHDVHTTVVLGAGLVLAELAREGRLPRPVRLLFQPAEEVLPGGAPDAVEAGVLDGVGRILALHCDPKVDVGRIGLRIGAITSACDRLEVSLDGAGGHTARPHLTTDLVTAAAKVITEVPAVLSRRVDTRSGLAVTWGRVESGHACNVIPQHAELSGTVRCLDLPAWREAPDLVHAAVDEIATLHGAKSEINYVRGVPPVVNEESSVELLRRAMETRRGSYAVEGTEQSLGGEDFSWYLERVPGAMARLGVRKVGDTARRDLHCGDFDVDEGAIEVGVELFTAAALLD
>NC_016582.1|WP_055414218.1|5810250_5811285_-|hypothetical-protein
MAFVESPVQLLNVLEWAYADGGDPEALTVVVLSPHDPMTRGQLRRMAELARDEGIAVRWEEARGGAGAPLKTIGGLRGPLRRADRIVIGDPFSRYVQLLLMLTRAQDLIVVDDGTATMEFVSQLASGEPLVRWHRRGTGRGAREMVFAPVSATARRRLTPGGNRRVEVFSSMPVEPPAGVTVTANSFAWTRDRFGPPTLTRGTDLVGTSLVETGVVDLERYLEAVASLARTHGATRYFAHRRESAEKLHRVAVEIGLEIVRPDLPLELIARRGPIGHTIVSFPSTVVHTLPLALVGTGVKVAVCDVDPAWLRSDASPRAQGFLSGVTGTARDAHRLQSMPAATP
>NC_016582.1|WP_014177250.1|5811453_5812389_-|N-acetylneuraminate-synthase-family-protein
MSSNNRLRQLGDKIAGPGHPVYVTGEIGINHNGDLENAFKLIDAAADAGCDAVKFQKRTPEICTPRDQWDIERDTPWGRMTYIDYRHRVEFGEDEYRAIDEHCKKRGLAWFASPWDTEAVAFLEKFDVPAHKVASASLTDDELLRALRATGRTIILSTGMSTPKQIRHAVEVLGSDNILLCHATSTYPAKAEELNLRVINTLQAEYPNVPIGYSGHETGLQTTLAAVALGATFIERHITLDRAMWGSDQAASVEPQGLQRLVRDIRTIEESLGDGVKKVYESELGPMKKLRRVAGVVAEGETSAEREPAGV
>NC_016582.1|WP_014177251.1|5812389_5813652_-|acylneuraminate-cytidylyltransferase
MSPSDRRVVAVIPARGGSKGVPAKNLAAVGGVPLVARAVRECLASRLVTDVVVSTDDAGIAAVARGAGAEVVQRPTAIAGDTATSEAAVLHALDTYEAAHGISAEVVLLVQCTSPFIVREDVDGVAEAVLDGGADTALTVAPFHGFVWRDAEDGTTTHASADASADASAETAGETTADGGYGINHDKSYRPRRQDRPQDLLETGAAYGMRVEGFRAERHRFFGRTALVRTDAARVLEIDDPHDLARARALAPLLDAPRPGALPTRDDIDAVVLDFDGTQTDDKVLIDSDGRELVAVHRGDGLGIAALRRAELALLILSTEQNPVVAARARKLRVPVLHGIDRKDLALKQWCEEQGIAPERVLYVGNDVNDLPCFGLVGWPVAVAGAHDVVRGAARAVTSTPGGDGAIREIASWILGKELS
>NC_016582.1|WP_043487045.1|5813839_5815195_-|hypothetical-protein
MPSRTNSPLRVAVLADSDTRWKWGALTAHRLVPDDTDSARRLDGFLLRGRATPTVRQLAEVGVRADSLREVTGVEFVSAVDRERYDVIVLSLVGGAVQAMLHGLARAWEGAERRPVVITGYVGVVYEKLADGLLLRHGADVVLANSRHDADRFRDVYTGVGASADSVVECALPFLGGAPYDTKAREGRAYPGGTVVFAVQPSVPDNRADRMYLLRRAVEHARAHPDREVLVKLRSKPGEHTTHIEELPYQKLVGKLGDDVPGNFRLAYGNMGEVLDTTDLLVTVSSTAALESLHRSIPTAVLTDLGVREALGNHHFLGSGCLASWDQLDAGHLPQPNPDWVSRQGVAADGAYETAFDAARERVAELAAADELPPLAPYYTRATAPGYLPARLARYGFEPDGRPRPGAAAGDSAQVSGFRRVVRNTMREAARGAYRHGVQRVAPVIRRMGEL
>NC_016582.1|WP_014177253.1|5815492_5816467_+|glycosyltransferase-family-2-protein
MVKLSVIVPFYNVQTYAPDTLRSLRANARDDFEFILVDDCATDGTPEILERAERDLPGAVYVRHEQNGGLATARNTGLDASRGEYITFLDGDDWLAPGYYEQLLGAIEELDCDFLRTDHVQVTGRARTIQRVPHGLRNVVMNPRDVILPADRSTSVDYAYAWAGIYHRRLADQGLLHFTHGLRTAEDRPWIWKLHREARSFAVVGLLGVFYRRGVASSLTQIGDVRQLDFIRAFDQVIEETAQDQDADSLLPKAVRTYCAIISHHLGNIERFEPAVAKKLRSMSAAAMKRMPQDVLKEALDSMDYERAARLRRLKRRPGTEVAA

Crispr_ID: NC_016582_11

• CRISPR_ID: NC_016582_11
• CRISPR_location: 6717451-6717564
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_11

Consensus_repeat	Method
CGTGTCCTTGTCCGCTACGGGCTCGGC	CRISPRCasFinder

spacers of NC_016582_11

>11.1|6717478|60|NC_016582|CRISPRCasFinder
GTCGGCCTTCGGCTCGGTGGTCGGCGCGGGACCGTCGGCGGGGGTGGCTTCCGCGTCGGC

CRISPR arrays and Neighbor proteins around NC_016582_11

CRISPR arrays

The CRISPR arrays of NC_016582_11

>merge|NC_016582|11|6717451-6717564|CRISPRCasFinder
CGTGTCCTTGTCCGCTACGGGCTCGGCGTCGGCCTTCGGCTCGGTGGTCGGCGCGGGACCGTCGGCGGGGGTGGCTTCCGCGTCGGCCGTGTCCTTGTCCGCCACGGGCTCGGC

>NC_016582|11|10|6717451-6717564|CRISPRCasFinder
CGTGTCCTTGTCCGCTACGGGCTCGGC	GTCGGCCTTCGGCTCGGTGGTCGGCGCGGGACCGTCGGCGGGGGTGGCTTCCGCGTCGGC
CGTGTCCTTGTCCGCCACGGGCTCGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_043487274.1|6705908_6707060_+|Dyp-type-peroxidase	unknown	unknown	gnl|CDD|273606
NC_016582.1|WP_014178066.1|6714484_6716254_-|methionine--tRNA-ligase	unknown	unknown	gnl|CDD|237029
NC_016582.1|WP_014178068.1|6719143_6721219_+|PhoX-family-protein	unknown	unknown	gnl|CDD|253386
NC_016582.1|WP_014178072.1|6724765_6726304_-|ATP-dependent-DNA-ligase	unknown	unknown	gnl|CDD|235108
NC_016582.1|WP_014178062.1|6711470_6712265_+|hypothetical-protein	unknown	unknown	gnl|CDD|226309
NC_016582.1|WP_043490883.1|6712426_6713320_+|intradiol-ring-cleavage-dioxygenase	unknown	unknown	gnl|CDD|239540
NC_016582.1|WP_170061347.1|6713919_6714372_-|DNA-binding-response-regulator	unknown	unknown	unknown
NC_016582.1|WP_014178073.1|6726412_6727759_+|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NC_016582.1|WP_014178064.1|6713327_6713801_-|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl|CDD|225039
NC_016582.1|WP_106436655.1|6704498_6705710_-|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl|CDD|163517
NC_016582.1|WP_014178060.1|6707052_6709347_-|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NC_016582.1|WP_106436392.1|6732158_6733772_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|340391
NC_016582.1|WP_055413977.1|6724017_6724683_+|3,4-dihydroxy-2-butanone-4-phosphate-synthase	unknown	unknown	gnl|CDD|376420
NC_016582.1|WP_043490893.1|6721683_6722730_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NC_016582.1|WP_014178061.1|6709478_6711329_+|aspartate--tRNA-ligase	unknown	unknown	gnl|CDD|234775
NC_016582.1|WP_014178078.1|6733786_6734212_+|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl|CDD|367422
NC_016582.1|WP_014178076.1|6731306_6731879_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_016582.1|WP_078610562.1|6728419_6731170_+|SpoIIE-family-protein-phosphatase/ATP-binding-protein	unknown	unknown	gnl|CDD|225827
NC_016582.1|WP_043490880.1|6703786_6704491_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_055414245.1|6722759_6723767_-|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl|CDD|377028

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_043487274.1|6705908_6707060_+|Dyp-type-peroxidase	gnl|CDD|273606	TIGR01412, Probable_deferrochelatase/peroxidase_EfeN, Tat-translocated enzyme. This model represents a small family of proteins with a typical Tat (twin-arginine translocation) signal sequence, suggesting that the family is exported in a folded state, perhaps with a bound redox cofactor. Members of this family show homology to Dyp, a dye-decolorizing peroxidase from Geotrichum candidum that lacks any typical heme-binding site.	1.89927e-63
NC_016582.1|WP_014178066.1|6714484_6716254_-|methionine--tRNA-ligase	gnl|CDD|237029	PRK12268, PRK12268, methionyl-tRNA synthetase; Reviewed.	0
NC_016582.1|WP_014178068.1|6719143_6721219_+|PhoX-family-protein	gnl|CDD|253386	pfam05787, DUF839, Bacterial protein of unknown function (DUF839). This family consists of several bacterial proteins of unknown function that contain a predicted beta-propeller repeats.	0
NC_016582.1|WP_014178072.1|6724765_6726304_-|ATP-dependent-DNA-ligase	gnl|CDD|235108	PRK03180, ligB, ATP-dependent DNA ligase; Reviewed.	0
NC_016582.1|WP_014178062.1|6711470_6712265_+|hypothetical-protein	gnl|CDD|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	1.62522e-11
NC_016582.1|WP_043490883.1|6712426_6713320_+|intradiol-ring-cleavage-dioxygenase	gnl|CDD|239540	cd03457, intradiol_dioxygenase_like, Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the extradiol-cleaving enzymes which break the C2-C3 or C1-C6 bond and utilize Fe2+ and Mn+. The family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases. The specific function of this subgroup is unknown.	1.70941e-77
NC_016582.1|WP_014178073.1|6726412_6727759_+|SpoIIE-family-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	5.5452e-42
NC_016582.1|WP_014178064.1|6713327_6713801_-|carboxymuconolactone-decarboxylase-family-protein	gnl|CDD|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	1.51951e-23
NC_016582.1|WP_106436655.1|6704498_6705710_-|right-handed-parallel-beta-helix-repeat-containing-protein	gnl|CDD|163517	TIGR03805, beta_helix_1, parallel beta-helix repeat-containing protein. Members of this protein family contain a tandem pair of beta-helix repeats (see TIGR03804). Each repeat is expected to consist of three beta strands that form a single turn as they form a right-handed helix of stacked beta-structure. Member proteinsa occur regularly in two-gene pairs along with another uncharacterized protein family; both protein families exhibit either lipoprotein or regular signal peptides, suggesting transit through the plasma membrane, and the two may be fused. The function of the pair is unknown. [Unknown function, General].	4.13974e-20
NC_016582.1|WP_014178060.1|6707052_6709347_-|SpoIIE-family-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.22352e-43
NC_016582.1|WP_106436392.1|6732158_6733772_+|sensor-histidine-kinase	gnl|CDD|340391	cd00075, HATPase, Histidine kinase-like ATPase domain. This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.	4.04979e-17
NC_016582.1|WP_014178078.1|6733786_6734212_+|roadblock/LC7-domain-containing-protein	gnl|CDD|367422	pfam03259, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	6.48122e-23
NC_016582.1|WP_043490893.1|6721683_6722730_+|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	6.72809e-07
NC_016582.1|WP_014178061.1|6709478_6711329_+|aspartate--tRNA-ligase	gnl|CDD|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NC_016582.1|WP_014178076.1|6731306_6731879_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.13016e-10
NC_016582.1|WP_078610562.1|6728419_6731170_+|SpoIIE-family-protein-phosphatase/ATP-binding-protein	gnl|CDD|225827	COG3290, CitA, Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms].	2.3143e-62
NC_016582.1|WP_055413977.1|6724017_6724683_+|3,4-dihydroxy-2-butanone-4-phosphate-synthase	gnl|CDD|376420	pfam00926, DHBP_synthase, 3,4-dihydroxy-2-butanone 4-phosphate synthase. 3,4-Dihydroxy-2-butanone 4-phosphate is biosynthesized from ribulose 5-phosphate and serves as the biosynthetic precursor for the xylene ring of riboflavin. Sometimes found as a bifunctional enzyme with pfam00925.	6.61831e-64
NC_016582.1|WP_055414245.1|6722759_6723767_-|endonuclease/exonuclease/phosphatase-family-protein	gnl|CDD|377028	pfam03372, Exo_endo_phos, Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12, and Nocturnin.	3.98416e-23

Protein sequences

>NC_016582.1|WP_014178066.1|6714484_6716254_-|methionine--tRNA-ligase
MARHLITSALPYINGIKHLGNMVGSMLPADVYARYMRQRGHDVLYICATDEHGTPAELAAKEAGLPVGEFCAQQHHAQKAVYDGFSLAFDYFGRSSSAQNVEITQTIARELKANGFIEERSIRQVYSNADGRFLPDRYIEGTCPHCGYDKARGDQCENCTRVLDPTDLINPRSAISGSSDLEVRETKHLFLLQSKLAGEVAAWVDEHGKDWPTLASSIARKWLNEGLQDRAITRDLDWGVPVPADTWPDLAAEGKVFYVWFDAPIEYIGATKEWSDLDPANRDWKSWWYDVDQTVRYTEFMAKDNVPFHTVMFPATLLGTRDAWKKVDYVKAFNWLTYYGGKFSTSQKRGVFTDAALELLPADYWRYFLMANAPESDDTSFTWEHFAATVNKDLADTLGNFVNRVLSFSRKRFGDEVPAGKAAGEAEARLGEEIARLLAEYEEYMDALQFRKAAAALRALWSAGNSYLEEKAPWLEIKTDQEGAALTLRTAMNLIHLYAVVSEPFIPASARAMRSAFALADDTAPWVGQEEAKALASVPAGTAFTVPPVLFAKITEEDLESYRVRFGGAPEQAGGGASTGVETEGKPVE
>NC_016582.1|WP_170061347.1|6713919_6714372_-|DNA-binding-response-regulator
MWSPSVGKSRSAVPDAPRVTVTVHGPDPLSRAGVVRHLRHQPTVELIHRPRPFSDEPRGTVAIMLAERLDARAGAELRRLVRGGEQRVVLVTGELRETELMTVVEYGVRAVLWQHRATPRRLLRAVHRAARAERTDPCGVDQRLTEHFVY
>NC_016582.1|WP_014178064.1|6713327_6713801_-|carboxymuconolactone-decarboxylase-family-protein
MDARLNYYGNPVAAKFAKYINSAGKVVGDSTLPAATQELVKIRASQINGCGFCTDMHTKDAAHAGETSVRLNLIAAWREAKVFTEAERAALELTEQGTRIADAAGGVTDEAWANAAKHYDEDQLAALVSLIALINAYNRMNVIIQQPAGDYQPGQWG
>NC_016582.1|WP_043490883.1|6712426_6713320_+|intradiol-ring-cleavage-dioxygenase
MSRRRMIVAGGAAVAATGIGAGIAASASASETSSSSAASPSASSTATSGEVCYRLTSETTEGPYYIDADKIRKDITESKEGIPMTLRLKVIDSDTCKPVRKAAVDIWHCDALGLYSGYESSSTGGGGTPPTGTPPTDAPTGTPTDAPTGTPPGGGGGHQEPTDDKRYLRGTQLTDQHGFVEFRTVFPGWYRGRCVHIHTKVHVGGALTDSGYEGGHTCHTGQLFFAEEAVLASAEVAPYSTSTTERTTLDEDTIYPGNGAQGGLLTLKYKKGRIEKGVIGTLTLGVDPDTTHDGTDL
>NC_016582.1|WP_014178062.1|6711470_6712265_+|hypothetical-protein
MASAAAALVIAALAGCGASADGPAGGPEPRAGATDAAAGQGSAAPGPGTTAQRPAPAALSKHLPGLGPRTLAKVPDNARQVVVVTGEGRDSSRATAVVYQRRNPDGDPDMAAGADWRAVATWDAHNARRGWTDHHVTGDLRSPIGVFPLTDAGGRLPDPGTRLSYEQSSGFTIGGTGFEGEPLAGSFDYVVAINYNRKAGTSPRDWTRPLGQKRGGGIWFHVDHGGPTQGCVSISKKHMKKLLLILDPERHPVVVMGDAASLAR
>NC_016582.1|WP_014178061.1|6709478_6711329_+|aspartate--tRNA-ligase
MHRYRSHTCGELRAADVDTDVRLSGWLHNRRNLGGILFIDLRDHYGLVQLVVRPDTPANDALSSISKETVVRVDGRVIARGAENVNPDLPTGEIEVEVTDVEVLGGADPLPFTVFPEDGVNEERRLEYRFLDLRRERMHRNIMLRSAVISAIRQKMTAQGFNELATPILSATSPEGARDFLVPSRLHAGKFYALPQAPQQFKQLLMIAGFDRYFQIAPCFRDEDARADRSPGEFYQLDVEMSFVEQEDVFQVIEKVMTELFEEFGGGRHVTSPFPRVPFREAMLKYGSDKPDLRAQLELVDVSHVFADSGFKAFAGKHVRALAVPDTADQPRKFFDQMGEFAVEQGAKGLAWVRIGEDAKLTGPIAKFLTDEDVEKLIAEVEGKPGTAIFFGAGEFDEVSKIMGAVRVEAARRAGHFEENVFRFCWIVDFPMFERNEDTGQIEFSHNPFSMPQGGLEALRTKDPLDILAWQYDIVCNGVELSSGAIRNHEPDVMYQAFEIAGYSREEVEREFGGMLRAFHFGAPPHGGIAPGVDRIVMLLADEPNIRETIAFPLNGNAQDLLMGAPSEVDEARLRELHLSIRKPQIKQAAEKAADKGGEKAGEKAGDKPAEKPAGE
>NC_016582.1|WP_014178060.1|6707052_6709347_-|SpoIIE-family-protein-phosphatase
MRTEDLLAALATGLWRWDTVSGAVSYDAEAARLVGLPAEPVTLPESAARACFHPVDWVEAKAIVNLAVAEGTLAEARVRVVDEKGRVLRTVRSRCRPVIHGGDPGRRGAENGYDLVGTLQEVPETLPGTSAATLTSVTGDWRRGREAFLLDAGRALAEAPSTAEVLRVAAGLSMPGFSPDGLAVFGVKGDRISLIGRHGNLAGDEHPCPAQPLDADCPAAEVIRTGRAVYLPGPEDYRDRFPGSWARTRPVAHRAWAFLPLIVAGRTIGAWMASFAHSVSFSPDERSVLTTVARMLAQALSRASLQETERELTDGLQRSMLPADKPAIPGLTVAARYVPTGGGLQVGGDWYDVIGLPSGRTALVIGDVQGHDVRAAGIMGQLRIAVRAYASEGHHPDAVLSRASRFLAGLTEPPGPGGDAPYDPRFATCLYMEVDPVAGTLDIARAGHPDPAVRLADGTMMIRPTGGGLPLGVDPDTDYPTTRVVLEPGETLLMCTDGLIETGGHDVESGWDRIRAVFEHTTTDGADHAAAAGAADTPGAADTPGTVGESCATSIAAAVDASAGSASPAALAALEADDLDALAEALVQAVHGPPSHHTTGHLADRREDDIALLLIRRDAEVCLVGPGSAPVRRTAVTVAQAEPERIAEARQQLRDMLHDWTDHDQVESAVLMLSEMVTNVLVHTDGDALLVAEVSGRAGARRLRLDVADGSDELPHRRRPGELASSGRGLMLMEMLADAWGVDPRGDGKCIWYELYEARPDGLS
>NC_016582.1|WP_043487274.1|6705908_6707060_+|Dyp-type-peroxidase
MRQADSRPSRRAFLGATGTVTAAGLSAGCQSSSARPDRSDAPAPTPPVSPTGRYQAGITLPQPAQRNVLAVVADLVDAGSVRPLLAELGEAIGKLTAGTDTRLMGLSPGDLTVTIGVGPRLVRKVDPALPGAKDLPRFSREQIAPRARGGDLLIQICADDPLVIPVVAAALLEQAGERIRERWRQSGVRGPNVPVDKGLAAPRNLFGFVDGIVGPHTKAEQQRDLWLAGPAPVAHGTLAVLRRMELDLPRFAKLSVAEQEAVFGRRRASGVPLSGGTIASGPDLGAKTPDGRYLVPADAHARRAHATAVGVGLMLRRSYSIDGPAPGLLFMSFQNDIRTFTSTLTRMDNSDALLDYTTTTASATFLILPGFDKQHPLGSGLFS
>NC_016582.1|WP_106436655.1|6704498_6705710_-|right-handed-parallel-beta-helix-repeat-containing-protein
MPADAPTISAAVSLARPGDLVLVAPGKYHESVKISTARITLRGESRDKVVIDGRLRQPNGIVVAAPGVAVENLTVRNNTQNGVLVTGSAKAAAGMPGQSGGYDTGDEPVTFLKSFLVSHVTSTRNGLYGIYAFSAQNGVIEHSYTSGSADSGIYVGQCKPCRIVVRDNIAELNAVGYEGTNASGDMYVVGNRLVGNRVGLTTNSDHQEKLLPQKDAVIAGNLIAANQQAATPEQADGGWGIGIGVDGGTANQFVRNRIADNSNAGLVITATADIQPNGNRILDNTFAANSVDVGWTFPTATKGRGNCLRGNELRTTVPAKLATTASCPRPARSLSPSGTWAKPTAPGGIPFTEVAAPGRQPQFPKATTTGATAVPAVPALPDTADIPLPSVSLLATGARVLTS
>NC_016582.1|WP_043490880.1|6703786_6704491_+|hypothetical-protein
MTTFLVAGSGSAPTGPKELTSDQANRLAVTRFLNYQAGGRAVTIDVPGTAGGLTITGSIDFRGKIGYGVVHGTGRDSSSDGLIEWTATTVFVHPMTDPPAKAPARPPGSGWYNRPLQKYGSSLDSSLAIALKLGSDRPDNAELLPQNGAAWVGEDRLDGHQVDIMTGPSAARTTGARTTSGTAGADAVRYWIGSDGTMYRVRVGVASASQPVVIDFDTQKYVPVRPVPGATPAR
>NC_016582.1|WP_014178068.1|6719143_6721219_+|PhoX-family-protein
MRKLLPLINSHPGGRSALTCRYRCGDACFHEVPNTSDNAYIGDVIAGALSRRSVLRAGAVVSVAAAAGVTAVGRAPEAAAADGAAEATAADKGAGKAARGLRFSPVAPNTTDAVVVAEGHDQNVVIRWGDPILRGAPAFDPANQSAKAQSGQFGYNNDYMAVLDIPQERDRQLLVVNHEYTDEVLMFAGYDAANPTREQAEIAWAAHGLSVVATQEDRKLGKLTAVSRHRLNRRITATTPFEVTGPAAGSKLLRTSADPTGKRILGTLNNCGGGITPWGTVLSGEENFNQYFANAGSVTDPTTAARLKRYGLAGAATERKWERFDKRFDVAQEPNETNRFGWVIEIDPYDPESTPRKLTALGRFKHEAAEPRLTDDGRPVLYMGDDEKFDYFYKFVSSKRMMKGTSRAAREHNRTLLDEGTLYVAKFTGDSPAAEIDGSGKLPKDGEFDGSGEWIPLASGTTSYVEGMTAEEVYVFTRLAADKVGATKMDRPEDVEPSPRTGKVYVALTNNSDRGKAGKAPADEANPRNINKHGQILELTERWSDPAARRFSWKLFLVCGDPADPSTYFGGFPKDQVSPISCPDNITFDAYGNLWISTDGNALGSHDGLFGVATSGSRRGEVKQFLTVPTGAETCGPIVQDRRVLVAVQHPGELDGASVEKPASTWPDGPGKLTRPSVISVWRRDGGNIGV
>NC_016582.1|WP_043490893.1|6721683_6722730_+|LysR-family-transcriptional-regulator
MDQLRTLIVVHETGTALGAARVLGREQSSVQKQLDTMNRNFRDLCGEPLVLKQGRGKDVLFTGTGEALVELARGTLGDWLEGIHESRRRLGKTLMVGTTRFTLGYLAGAGERVAEEFEQRGIELKVGHVRTRDVLGKLRAKDVDLVCGSVVTSPQGNGVDNELDAFDVMEWRRSGVSLLTNLPHSRLPGPTVTSSELRTLPLVVSASGLMAGVLHTWFGADYRNKLHIAAEIDTVTYGFELLRSGLLRGCMLVTKGVAEAAGDPRVAYGRGMRAVELVNDTGPRLEVLLGAFTRRGERAHYEASHPLNLLWDALALENEQWRREQRWPTEGLEPDPFELANSYNPSES
>NC_016582.1|WP_055414245.1|6722759_6723767_-|endonuclease/exonuclease/phosphatase-family-protein
MIRPVLRPVRRFARPPRGRARQVAAWCAALPLALVGVVLGCRAADSDGITPVPQLLAFLPWLLVPALLGLVLAVAARWPLGCAWALATAAVTGWFMQPYDPGGPAPRPRGPVVAQLRVLTANLEFGGATKGLVDAVRREKPDLVSVQECDTRCGAALDSAALREAYPYRKVITVPGDAAHGSAILSTYPLTPEAGISGKLAMPRAVVRIAGRRLHVQVAHPMPPMPGQLDVWRTELGRLRAYAADRGDEPTLIAGDFNATQDHAAFRSLLDTGMRDSARAVGMSRTPSWPTLTTPALGAQIDHVLVSDALRPRAARFLDLPHTDHRALLVDLELH
>NC_016582.1|WP_055413977.1|6724017_6724683_+|3,4-dihydroxy-2-butanone-4-phosphate-synthase
MAVVEQTVAPERLLAVEQAIDAFAEGGFVIVYDELAKEHRGVLLLAAEHTHEGALKQLLDHTSGMVCVALPDGHADRLRLQRLTVDEEHTTTLLSAGFTVPVDLLGPTTTTGLSAADRSRTVQALADPQTTPDQLGCPGHVFPVCAMPGGVLEREGHAEAAVDLSRLAGLSGVTAVGAVVTADWELAGHEDLSRLAASRLLPLISVADLVAYRLARQALGR
>NC_016582.1|WP_014178072.1|6724765_6726304_-|ATP-dependent-DNA-ligase
MLLAEVARTSREVAATSARSEKIAALARLLSRVEPAEAPVVITYLAGRLPQRRIGVGWAGLRVRPEPAAGPRLGVLDVHQALDRVAAVSGTGATTERKRLVSGLMSAATEDEQAFLFGLIGGELRQGALDALAVEGLSAAVGAPPAEVRRAVMLGGSLGAVAQALLENGPPALSEFGLEVGRPVLPMLAHSARDLDEALDRLGPCAVEEKLDGIRVQVHRDKETVRVYTRTLDEITDRLPEVVAAARELAVERAVLDGEVIALDADGRPRPFQEISGRVGARLDVAGASASLPLYPVFFDLLAVDDRDLLDLSARDRHAELARVAPAPRRVRRLVAEDPRDEATRRAAREFAADVLARGHEGVMAKSLDAPYSAGRRGACWLKVKPVHTLDLVVLAAEWGHGRRTGKLSNLHLGARRPDGTYAMLGKTFKGLTDKQLGWQTEALLRLAVSDDGWVVRVRPELVVEVAFDSLQRSSRYPEGVTLRFARVLRYREDKPAEEADTVETVLALRDA
>NC_016582.1|WP_014178073.1|6726412_6727759_+|SpoIIE-family-protein-phosphatase
MAGHEQGAATGQQIDYEALFEATPSPNLVLGPDLVIVAVNQAYLNATRTRREDLLGRHVFDAFPDNPADPNATGTRNLGASLRRVLATGERDSMALQKYDIPVPGDEGEGVGEGGSDEGEGSEGGSDEGRGRRDRRDKGRFEERYWSPINTPVLGPDGSVQLIIHRVEDVTDFVRERAQAPLKRTAEMDADLRTRARELQEVNERLREAHARERSTALALQQAMLPALVPGLHLHVAVRYRPAVGSLNVCGDWYEVSELADGRIAAAVGDVVGQGLGAACVMGQLRSALSAAMRVVGTPSRALDALGLYARSLEGALAATAVQAVIDRSARTICYSCAGHPPPLLLRAEGDVVRLDKATDPPLGARPEHVEQPAATLPYTPGGILVLYTDGLIERRGEDIDVGLGRLADSLSRHGGLDPEQLADALLVDLGVTGGTVADDTALVVIGL
>NC_016582.1|WP_078610562.1|6728419_6731170_+|SpoIIE-family-protein-phosphatase/ATP-binding-protein
MARFKGRSWVLAARTFPGRRPRSRRRERPEAAGARSGSWLSTRSVAGQVFLLQLVIVLLLIAAASVALVLQVQHDAANEARHRSIAVAETFANAPGMPAALRSPQPTAVLQPLAEAARKDAGVDFIVVLNTKGIRYTHPDTSRIGHHFLGSYRPAVKGHTITETYTGTLGPSVRAVVPVTDSRGKVIGLVASGITVNKVSGLANRQMPILIGAAGASLALATGGTALVSRRLRRQTHGLDPAEMTRMYEHHDAVLHSVREGVLIVDGGGRLMLANDEARRLLDLPEYPEGRAVTELGLEPQMAQALASGQVVSDEVLVAGDRLLAVNNRPTDRDGGPPGSVATLRDSTELRVLSGRAEVAQKHLKLLYDASVEIGTTLDVGRTAEELAQVAVGRFADFVTVDLAEPVLRGEEPLAVGGIEMFRTAVRGISDVHPFYQVGTHFSFVSSTPQARGFASGQAAVEPDLREAHGWRAQDPEQTGLAIDYGVRSLVTVPLRARGVMLGMVSFWRMEKNAPFEEDEIALAEELASHAAVCIDNARRYTREHTMAVTLQHSLLPRALPEQSALDVAYRYLPAESGVGGDWFDVIPLPGARVALVVGDVVGHRLHAAATMGRLRTAVHNFSTLDLPPDELLSHLDDLVARIDQDETSESLEGGAGITGASCLYAIYDPVTRRCAMARAGHPPPAVVAPDGSVEFIDLPAGPPLGLGGLPFETAELELAEGSQLVLYTDGLIEDRRREIDAGLELLREALAHPGRTPDRTCADVLDAVLPARPTDDIALIVASTRVLGPDRVASWDIPCDPAKVAEVRAAAIEQLTEWGLPAAAPDMAFTAELVLSELITNAIRYATGPIRVQLLRDRNLICEVSDNSSTSPHLRYAATTDEGGRGLFLVAQFAERWGTRYTAEGKVIWAELALP
>NC_016582.1|WP_014178076.1|6731306_6731879_-|TetR/AcrR-family-transcriptional-regulator
MSSTERRERERAQRHQLIITAARELAEAEGWDAVTTRRLAERVEYSQPVLYSHFKGKDAIVRAVALEGFDDLGAQMRRARLAEISPKEALRALGRAYLDFAADRPALYEAMFIMPTDLAFAGTETPPALRAAFGEIVAVVGPRDGVGLYAEVFWGSLHGIAVLVHGKRMPAEHQGDRLDLLVEHFTPEAG
>NC_016582.1|WP_106436392.1|6732158_6733772_+|sensor-histidine-kinase
MSAHISSQPVKGLSMTRQALAVPLLAAVVVGGVGAWVTAEVPSAHRASVGLFCAVAAVLLCVAVAFASARAQAVRRLQARLAAVEADAARRTSAMQAEVNRRSAVMEAEAAKLADETIPSAVGQLREGETVDTVLSTLPSPASGAHDRVLKMLVREVATGERMRASAMAACANAAGRVQALATSMLADLREMENRHDEAVLGDLLKLDHTTAQAGRIADSIAVLTGARSGRRWTKPIVMESVLRGAVGRISAYQRVRIHSASTAAVAGYAAEGVMHALAELMDNAATFSPPTEEVHVYVQETHTGVVVTVEDGGLVMGPAALARAEKAVSSDPLDLTTLSGTRLGLAVVGQLARKHNLTVSFRPSSRGGTGVVVLIPQQLITHVSQDAATNPAPAARSAAARPATPQAANRSAAAPTATATATAASAPAAPTRTATPAPDPGPAAAPQPTSTEPTGGLPKRRRGETLAAASRPASPQARKAPADRPRPDATRLGAFRQAARGGSGAPCPGAEPVPCADDQAAEAHATPETSPENDQP
>NC_016582.1|WP_014178078.1|6733786_6734212_+|roadblock/LC7-domain-containing-protein
MNTTDRSLDWLLENLLKKTPGARHALVLSRDGLKLCLTSGLSLDQADQLAAIASGIQSLSHGASIEFGDGSGGVRQSMTEFHGGILFIVEAGEGAHLAVIAEDEADVGIIGHNMNELVEQIGDHLRAAPRVAAGDGGGATA

Crispr_ID: NC_016582_12

• CRISPR_ID: NC_016582_12
• CRISPR_location: 6934211-6934290
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_12

Consensus_repeat	Method
GTCGCGCCAGGAACCGCGGCCTG	CRISPRCasFinder

spacers of NC_016582_12

>12.1|6934234|34|NC_016582|CRISPRCasFinder
CGGAGTGGCGGCCTGCGGAGTCACGCCCTGCGGC

CRISPR arrays and Neighbor proteins around NC_016582_12

CRISPR arrays

The CRISPR arrays of NC_016582_12

>merge|NC_016582|12|6934211-6934290|CRISPRCasFinder
GTCGCGCCAGGAACCGCGGCCTGCGGAGTGGCGGCCTGCGGAGTCACGCCCTGCGGCGTCGCGCCCGGAACCGCGGCCTG

>NC_016582|12|11|6934211-6934290|CRISPRCasFinder
GTCGCGCCAGGAACCGCGGCCTG	CGGAGTGGCGGCCTGCGGAGTCACGCCCTGCGGC
GTCGCGCCCGGAACCGCGGCCTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014178267.1|6926955_6927870_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224054
NC_016582.1|WP_014178268.1|6927949_6928528_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224427
NC_016582.1|WP_014178283.1|6944503_6944875_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014178264.1|6922985_6923963_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223730
NC_016582.1|WP_014178265.1|6923973_6925200_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_016582.1|WP_014178263.1|6921678_6922923_+|kynureninase	unknown	unknown	gnl|CDD|226363
NC_016582.1|WP_055414254.1|6938265_6940824_+|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|133031
NC_016582.1|WP_014178274.1|6937474_6938167_+|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224715
NC_016582.1|WP_014178266.1|6925303_6926959_-|ABC-transporter-membrane-spanning-protein	unknown	unknown	gnl|CDD|226089
NC_016582.1|WP_014178282.1|6944131_6944476_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014178279.1|6942814_6943369_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379112
NC_016582.1|WP_106436401.1|6940820_6941447_+|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|132028
NC_016582.1|WP_014178278.1|6942052_6942703_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_055414253.1|6928544_6929501_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014178262.1|6920843_6921686_+|tryptophan-2,3-dioxygenase	unknown	unknown	gnl|CDD|188272
NC_016582.1|WP_014178277.1|6941452_6941971_+|hypothetical-protein	unknown	unknown	gnl|CDD|235906
NC_016582.1|WP_043491002.1|6935890_6937285_+|aspartate-aminotransferase-family-protein	unknown	unknown	gnl|CDD|235687
NC_016582.1|WP_014178270.1|6929715_6930999_+|adenylosuccinate-synthase	unknown	unknown	gnl|CDD|234904
NC_016582.1|WP_014178284.1|6944985_6945702_-|SLATT-domain-containing-protein	unknown	unknown	gnl|CDD|375613
NC_016582.1|WP_014178271.1|6931106_6932954_-|DUF4328-domain-containing-protein	unknown	unknown	gnl|CDD|270916

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014178267.1|6926955_6927870_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	9.54826e-89
NC_016582.1|WP_014178268.1|6927949_6928528_+|MarR-family-transcriptional-regulator	gnl|CDD|224427	COG1510, COG1510, Predicted transcriptional regulators [Transcription].	8.16447e-12
NC_016582.1|WP_014178264.1|6922985_6923963_+|alpha/beta-hydrolase	gnl|CDD|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	1.66956e-16
NC_016582.1|WP_014178265.1|6923973_6925200_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	9.35289e-108
NC_016582.1|WP_014178263.1|6921678_6922923_+|kynureninase	gnl|CDD|226363	COG3844, COG3844, Kynureninase [Amino acid transport and metabolism].	5.94484e-137
NC_016582.1|WP_055414254.1|6938265_6940824_+|glycosyltransferase-family-2-protein	gnl|CDD|133031	cd04188, DPG_synthase, DPG_synthase is involved in protein N-linked glycosylation. UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.	2.48214e-80
NC_016582.1|WP_014178274.1|6937474_6938167_+|GntR-family-transcriptional-regulator	gnl|CDD|224715	COG1802, GntR, Transcriptional regulators [Transcription].	3.82105e-36
NC_016582.1|WP_014178266.1|6925303_6926959_-|ABC-transporter-membrane-spanning-protein	gnl|CDD|226089	COG3559, TnrB3, Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane].	1.48864e-107
NC_016582.1|WP_014178279.1|6942814_6943369_+|GNAT-family-N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	6.03379e-37
NC_016582.1|WP_106436401.1|6940820_6941447_+|SigE-family-RNA-polymerase-sigma-factor	gnl|CDD|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	4.507e-38
NC_016582.1|WP_014178262.1|6920843_6921686_+|tryptophan-2,3-dioxygenase	gnl|CDD|188272	TIGR03036, trp_2_3_diox, tryptophan 2,3-dioxygenase. Members of this family are tryptophan 2,3-dioxygenase, as confirmed by several experimental characterizations, and by conserved operon structure for many of the other members. This enzyme represents the first of a two-step degradation to L-kynurenine, and a three-step pathway (via kynurenine) to anthranilate plus alanine. [Energy metabolism, Amino acids and amines].	1.28756e-140
NC_016582.1|WP_014178277.1|6941452_6941971_+|hypothetical-protein	gnl|CDD|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	0.00131921
NC_016582.1|WP_043491002.1|6935890_6937285_+|aspartate-aminotransferase-family-protein	gnl|CDD|235687	PRK06062, PRK06062, hypothetical protein; Provisional.	0
NC_016582.1|WP_014178270.1|6929715_6930999_+|adenylosuccinate-synthase	gnl|CDD|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NC_016582.1|WP_014178284.1|6944985_6945702_-|SLATT-domain-containing-protein	gnl|CDD|375613	pfam18183, SLATT_2, SMODS and SLOG-associating 2TM effector domain 2. The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family is the only prokaryotic SLATT family to exist as a standalone domain, with no as-yet discernable genome associations.	4.54868e-122
NC_016582.1|WP_014178271.1|6931106_6932954_-|DUF4328-domain-containing-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.0232e-77

Protein sequences

>NC_016582.1|WP_014178271.1|6931106_6932954_-|DUF4328-domain-containing-protein
MENLGAQDPRWIGEYRLLGRLGEGGMGRVYLARSARGRTVAVKLVKAELARHADFRSRFQREVAAARRVGGQWTAPVLDADTEAEVPWVATGYIGGPSLHDVVAEQFGALPEHSVRTMAHGLALALRDIHGAGLIHRDLKPSNILITIDGPRVIDFGIARALETIAGVGTNLTVAGAVVGSPGFMSPEQVRGEAVTTASDVFCLGSVLAFAATGRQPFGNVTSGVHALLYRIAQEEPDLAGLPEGLLELITGCLHKDPAVRLSVEDVVARTAQEAYPAATGTWLPGELLAKLGRDALQLLEMEADSDDSAESATDSDTATLRATGPVRSVGAAAPGPATPGTPSGYATPPAPGAPAAPGYPASGAQPGYPMAGGAGQPWQAAHHHFPGPISSPPARSLRTSRGLGSALRWLLGAFALLSVAHLGLSGTLFSAYDDVLVGTGSEGAITDAKNSLEIFEVFTGVLAILLVVMFPVWFRRVYMNATFLAPGRQRYDSGLAAGSWFIPVAQLWMPKQMANDIWTSSAPPGTRPASRAVLNWWWALYVTMFVVVAVSTLAEPLARSTEDRQVVAGLNIFDDLVSIPASVLAMVVVARITKMQHPQHWQPEGAAFGPPVMR
>NC_016582.1|WP_014178270.1|6929715_6930999_+|adenylosuccinate-synthase
MPALVLLGAQWGDEGKGKATDLLGGSVDYVVRYQGGNNAGHTVVVGDQKYALHLLPSGILSPGCTPVIGNGVVVDPAVLLSELSGLNARGIDTSKLLISGNAHLITPYHTTLDKVTERFLGKRKIGTTGRGIGPAYADKINRVGIRVQDIFDESILRQKVEAALDFKNQVLAKLYNRRAIAVEQVVEELLGYADQLSGFVADTTLLLNNAIDDGQVVLFEGGQGTLLDVDHGTYPFVTSSNPTAGGACTGTGVGPTKINRVIGILKAYTTRVGAGPFPTELLDEDGDKLRTIGGERGVTTGRDRRCGWFDAVIARYATRVNGLTDFFLTKLDVLTGWERIPVCVAYEIDGKRVDELPYSQTDFHHAKPIYETLPGWSEDITQAKSFDQLPKNAQKYVSALEEMSGAPISAIGVGPGRDETIQINSFL
>NC_016582.1|WP_055414253.1|6928544_6929501_-|hypothetical-protein
MLIDPTARRTDGESVRIAKDVLCAGASAKICLPEGPEEVERALARRGSRRPVLVGDHRALLRTVELLHRKRELADAALSVVPVGGSATVALARALGLPTDAVSAARTALDGTAHRRDLLVDESGGVVLGGLRIFGGEQPGSGDRDANGAGDASEDGDRDASRDRDGSGAVSGTGGGTGGGTGGYDGGHQPWWTPAARTARTALTLLSLQGGGLGGSRRRTRPPAQRLRVEADGVLLADLDRPVERVSVSTAAAGRGGLADVVVHQCAGDGPVRARARAITVSGPDFRYHADTLTRGPVRTRTWTVLTEAWRLMVPRGE
>NC_016582.1|WP_014178268.1|6927949_6928528_+|MarR-family-transcriptional-regulator
MKGDEAAVTEVTRQESARDGEGVDFDRDDEAVSQFVERFAADMTEAGMQRMGARVFAALLASDSGKLTAAEIAELLQISPAAVSGAVRYLAQLNLITREREPGTRRDQYRLYNEVWYEAVSNRDQILTRWQHTMRDGAKVLGPHTLAGARAIRTAEFYEFMQKELVEMLARWRAHVEGAHLEVPHVGEQKTG
>NC_016582.1|WP_014178267.1|6926955_6927870_-|ABC-transporter-ATP-binding-protein
MTTAISTSGLHKSFGRTHALDGLDLEVETGEVHGFLGPNGAGKSTTIRVLLGLLRADSGAVQLLGKDPWHDAVELHRRIAYVPGDVTLWRNLSGGEVIDLYGRLRGGLDQDRRTELLERFELDPTKKGRTYSKGNRQKVALVAAFASDVDLLIMDEPTSGLDPLMEEVFRDCVIEERERGRTVLLSSHILSEVEALCDRVSIIRKGRTVESGSLAELRHLTRTSVTAELSGPPNGLSALPGIHGLDIQGKRVKLQVETDKLDAVLRQLGESGVRSLISTPPTLEELFLRHYQDDIRDEAEAVAR
>NC_016582.1|WP_014178266.1|6925303_6926959_-|ABC-transporter-membrane-spanning-protein
MTAVADTRVSAPERTGSRDLAGTGTLLRLALRRDRIMIPVWALAIGMTGSSTLSRMKSTYETAADRANVAKDMNTNGALRSMLGVAFDDSYGALTAWRVGTFLAAFAGIMSLLIVIRHTREEEESGRQEALSAGMVGRRAGLTSALLTVAIANAAITLLVVATLAGEGSGGALALGLSIGLTGLVFGGLAAVAAQITENARLARGLAAAAVGVAYLLRMAGDAAKDASEGSSHVLVWLSPIGWAENTRPFAQERWWTLLLLAVLAAASFAVAYVLTGRRDVGASFFASRPGPAAAGKSLQGAYGLAWRLQRGTLLGWVVGVALSAAMLGGVANGAGDIVGDSEKNREIIERMGGAQNIDDAFLAAMISLIGVIVTVHTATAVLRLRAEETDQRAEPLLANAVSRLRWAMSHLVIAYLGPVVILAAGGLGAGIVYAAAADDLGGELPRVLGASLAQIPAVWVVTSVVVLLFGLLPSYTTSLGWAVVGVVVAIGWLGPALDAPQAVLDLSPFSHLPKLPGESVSAAPFVWLLLGSAVLTAAGLWGLRRRDMTN
>NC_016582.1|WP_014178265.1|6923973_6925200_+|cytochrome-P450
MSSSAAPAPVFDPWQPSFVADPYPAYAALRERGRAHYFEASRQWLIPRHEDVRVLLRDRRLGRTYLHRFSHEEFGRTAPPPEHEPFHTLNGHGMLDLEPPDHTRLRRLVSKAFTPRTVERLAPVVERLADELVEAFVAEGGGDLVAAVAEPLPVAVIAEMLGIPPADRAQLRPWSADICGMFELNPGDEAARRAVRASVEFSEYLRELIAARRRNPGEDLISGLVAAYDEGDRLTEQEMISTCVLLLNAGHEATVNSTGNGWLALFRHPDQLALLRSDPDALLPTAVDELLRYDTPLQLFERWVLDDIEVGGTVIPRGSEVALLFGSANRDPERFPDPDRLDLSRTDNAHFSFGGGIHYCLGAPLARLELAASFGALLRRAPGLRPAAEPRWNPGFVIRGLQELLVEV
>NC_016582.1|WP_014178264.1|6922985_6923963_+|alpha/beta-hydrolase
MTDQAGPADQAGPAASAEAEEASLFGLAPVSPDRVAAYGDHRDQVVDFYLPEAETQAGAAALPAPLVLLFHGGAWRAPYDRRHISPFAAYLAGRGFVVASVEYRRGGPDGGDGSPPRAGRWPETLDDIAAAVDTVPGLARGLALPVDPARVVLAGHSAGGHAALWAAARHVLPPDCPWYLPSPPPVCGVVALAPIADFATARELRVCSDAVSQFLDLDIPDLDIPDGDIPDGEAHHLDRLPLADPAALLPTAVPTTIVQGVTDIDVPPQVAYAFTETARRAGQPVRAVRLASTGHFPLIDPTAAAVRTVADEIAHVARTTRREGR
>NC_016582.1|WP_014178263.1|6921678_6922923_+|kynureninase
MSEPNVTLAEEAAKLDAADELRAKRADFVLDDTVYLDGNSLGALPAAVPARLADVVAREWGQLRIRSWEESGWWTAPERIGDRVGRIVGAAPGQVVVTDSTSVNVFKALVGGVRIVQARDVSRDEILVDESTFPTDGYIAESAARLTGCTLRPVPAPEMAAAVGPRTAVALVNHVDYRTGRLHDLPGTTTAVHAAGALVVWDLCHSAGALPVGLDAHGVDLAVGCTYKYLNGGPGSPAYLYVAREHQPRFDSPLPGWNSHADPFGMAPAYTPADGAVRGRVGTPDILSMLALEAALDVWDGVSTAAVRAKSLALTDFFLRCVDTYVPAGRVESVTPAAHERRGSQIALRCADAGEAMAELIRRGVVGDFRRPDVLRFGFTPLYTGFADTERAARVLAAVLAGEPGEAGAPGEVA
>NC_016582.1|WP_014178262.1|6920843_6921686_+|tryptophan-2,3-dioxygenase
MSHQPAPHEAEPDTPNLDFQGTTPYEDYVQASVLTHLQHPLSDDPGEMVFLVTTQVMELWFTVIVHEWQTAAQALREDDLPTALAALKRSTYELESLNASWKPLAHLTPGQFNSYRSALGEGSGFQSAMYRRMEFLLGEKSASMLVPHRGAPRVHGELEKALTEPSLYDEVLGYLARQGYAVPESVLDRDPTRRYEPDAAVERVWQEIYSGPDDTAPARLGEALTEVAELVWRWRNDHLVATRRAMGAKAGTGGSAGVAWLEKRATKNVFPELWTARSHV
>NC_016582.1|WP_043491002.1|6935890_6937285_+|aspartate-aminotransferase-family-protein
MAAQPAHSAPTPGPTPDPATGAAVKAADRAHVFHSWSAQGLIDPLAVAGAEGSYFWDYDGNRYLDFSSQLVNTNIGHQHPKVVAAIQEQAARLCTFAPGFAVDVRSEAARLVAERTPGDLDKIFFTNGGAEAVEHAVRMARLHTGRTKVLSTYRSYHGATAAAINLTGDPRRWASDTASAGVVHFWGPFLYRSPFHATDERQECERALAHLAETIAFEGPQSIAAIILETVPGTAGIMVPPPGYLAGVREICDRYGIVFILDEVMAGFGRTGHWFAADHFGVTPDLLTFAKGVNSGYVPLGGVAISAAIAADFDQRPYPGGLTYSGHPLACASAVATINAMAEEGIVANAAAIGAEIIGPGLREIAERHACVGEVRGLGVFWAVELVKDKATREPLVPYNASGPANQPMADFAAACKRGGLWPFVNMNRTHVVPPCTITEAEAKEGLAILDEALSAADAHTTTA
>NC_016582.1|WP_014178274.1|6937474_6938167_+|GntR-family-transcriptional-regulator
MPVPGTSPVKRSTLRQQIADALCDEVLAGRLPAGRQFTVKEMADQYGVSATPVREALLDLCAQGLLDVEEHRGFRVHEFTFEDFRHMINARNMVVEGLFRHSVEETLRTMTPQALASVRRRAEEAERAARSGDLDILIGYDLRFWRELCGLVGNPYILDFLQRLRVQSWVFTVPYLRRVPDLRGRLWAGHCELTAAVTRGDAEVSERLITAYNAHSVALIERLVSGDEKG
>NC_016582.1|WP_055414254.1|6938265_6940824_+|glycosyltransferase-family-2-protein
MALRPATGTGIDTGIDTVDLTVVVPAYNEEHRLPRTLDAICRYLRSSPGRHAEWELIVVDDGSSDATAAVVRDAAEAEPRIRLLAPPPTSAGYARNHGKGHALRLGVLASRGRRVLVTDADLATPIEELPALHDRLDAGFAAAIGSRAHPDALIEVDQHPLRRLAGRAGNRVIRAVVLPGVGDTQCGFKLFDGDRARAAFGRSRLDGWGIDVEILRAFRRADWPVAEVPVRWAHQAGSKIRPLDYGRVLLELLRLWRRGVRERLRAGDTAVLLGYLLLSVLLYKGLWADVGHRYLIDSGQDQNQWEWFFAVTADKIFGGSGLGDPFFTELQNTPLGVNLMANTAMLGLGVPLAPVTALFGPGATWALVLTCGLAGTAGAWYWLLRKRFVRARRAAALGGALCAFAPPMISHATAHPNFAVLFMMPLIIDRLLRLCEGVRVRRDGVVLGLLLTYQVFLGEEALLLAAVGLVLFAAGYTAVRPAQARAAVRPLVRGLAFAAAVCVPLLAYPLLWQFFGDQSYHSVLHGPVGNSPRAFWEFAGRSLAGHEATADALAINRTEQNAFFGWPLLALTAAVVVWLWRDPRVRALGWVAFAASVLSLGRTIPVPWTGIVLPGPWRALAGQPLFESVIESRVAMAAVPALGILLALACDQLCALGAREPGAGAPGTDKAGEPGGVDRALRIVGWAAVAAALLPIAPTPYTTADRVPVPSFIADGTWRAHVPKGHSLVPVPLPSPGNAEALHWQTAAGLGFPLPGGYFNGPGGPDRKGIYGPQYRYTSALLDEVLRTGQVPHIGQKQRRAVRADLEFWRAGAVVLAPQPGDEALRVTLERLLGWQGEWIGGVWVWEVHGGT
>NC_016582.1|WP_106436401.1|6940820_6941447_+|SigE-family-RNA-polymerase-sigma-factor
MSRAAGDRASGDRASGNRVFGDRASGGRASEDRAEAEGAYTAYVSARLPALRRIAHLLCKDPHRADDVVQAALTKLYVHWNRARAADDLDRYVHTILVRCFLNEQRLGWARVVRLSGAPHETPGLPPVAGVPDIETRTVVHTALSRTPARQRAVLVLRFLCDLPVAEVAAVLGCSEGNVKSQTARGLARLRAQLGGQPIVPMPPVGKE
>NC_016582.1|WP_014178277.1|6941452_6941971_+|hypothetical-protein
MRDDELEREAARLLSPLRGLEPGPGAPGVDVGRAVWHGRRRVRARRAALPVAAGLVVALVAVALALAVRVLPGGSGAPPAGPGPTRTVTTTVDPSPSQSPTETSSASPSGSEYEPTTDPPSGSPTGSPSGSPGAPTDTASGTPSGTPSGPDMGAFTSPASPSGTTSTTTAPP
>NC_016582.1|WP_014178278.1|6942052_6942703_+|hypothetical-protein
MACDLWLVPLVDVLCHSPDNPFAEEIAAYDKALGDAGLPPVPVFGYMPGLSGDVAPVAAFDYDALHLLRRAYLLQVCGLAVTPVDELGGDYEQLLEMFEPTAQQSHLVWHYDHAGAYVPVDFERPLSNDELLEGGGPLGSSHGLLRELETVAPALGIDPANPPATPAPPARPTTLEEPAAPIPYEDSPFARERHVWLGLHAAATRSLGQGSMIVFS
>NC_016582.1|WP_014178279.1|6942814_6943369_+|GNAT-family-N-acetyltransferase
MSELRTDRLVLRGWRESDLAPWAAMNADSEVREYFPGTLTREQSEASVARFQADLGRRGWGWWAVEVKATGAFIGFTGLDPVDEDMPFTGVEVGWRLARPHWGHGYATEAALAALDHGFGSLALTEILAITTATNLRSQAVMRRIGMTRDPADDFDDMTVPVGPLRRSVVYRLRGDDHRQAVRG
>NC_016582.1|WP_014178282.1|6944131_6944476_-|hypothetical-protein
MTTASITGATVPPMPEKTPKALRAAIAQHAPKLLVDFERHWRRDIMDTYDLAPVPAFMARWWGEYALARNPSLEAEVHRLEDDAAQEPDYARAKAMIEEAGRLRREAAKAEPGQ
>NC_016582.1|WP_014178283.1|6944503_6944875_-|hypothetical-protein
MREQKDPAAHPDYQHPDIKRVQATRKAVADAERELAKLREQLDDDVRVAMTPSAGEKLPYGRVKRLQLLFGYEDNSNLYRMRDRSIQRAEKSFTENSDKDDDAKPSAGNDENVIPDQTDTAAA
>NC_016582.1|WP_014178284.1|6944985_6945702_-|SLATT-domain-containing-protein
MQPEGLPRQEGAKKQGDLLGRPFPHGDWGEPAERLDALYRWVEDGALQVAEWYLADRVWKRRTARALRVGAAVLGVVGASLPLLDLNGVLGDGAAWGCLVLLIAAACVACDRFFGLTSGWMRDVATAQAVQRRLETLQFDWASESVREVLGPTEGTAAEAVERCLAVLRRFCEDVSELVRTETAGWMVDFGSGSAPLFTQTLVAQGSRPEGGGPTNRLPMPPTARPNMPRQRPPEPPR

Crispr_ID: NC_016582_13

• CRISPR_ID: NC_016582_13
• CRISPR_location: 7095744-7095874
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_016582_13

Consensus_repeat	Method
CGGCGTCTGCCTGCCGGACGGTG	CRISPRCasFinder

spacers of NC_016582_13

>13.1|7095767|31|NC_016582|CRISPRCasFinder
TCTGCGCGACGGCCGGCGTGTACGCCTCGTC
>13.2|7095821|31|NC_016582|CRISPRCasFinder
TCGGCGCCGTGGGTGGTGTCTGCGTCCCGGA

CRISPR arrays and Neighbor proteins around NC_016582_13

CRISPR arrays

The CRISPR arrays of NC_016582_13

>merge|NC_016582|13|7095744-7095874|CRISPRCasFinder
CGGCGTCTGCGCGACGGCCGGCGTCTGCGCGACGGCCGGCGTGTACGCCTCGTCCGGCGTCTGCCTGCCGGACGGTGTCGGCGCCGTGGGTGGTGTCTGCGTCCCGGACGGCGCCTGTCTGCCGTGCGGCG

>NC_016582|13|12|7095744-7095874|CRISPRCasFinder
CGGCGTCTGCGCGACGGCCGGCG	TCTGCGCGACGGCCGGCGTGTACGCCTCGTC
CGGCGTCTGCCTGCCGGACGGTG	TCGGCGCCGTGGGTGGTGTCTGCGTCCCGGA
CGGCGCCTGTCTGCCGTGCGGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014178401.1|7082432_7083800_+|RICIN-domain-containing-protein	unknown	unknown	gnl|CDD|379501
NC_016582.1|WP_014178416.1|7103005_7104118_+|septum-formation-initiator	unknown	unknown	gnl|CDD|274798
NC_016582.1|WP_014178409.1|7091621_7093013_-|Na+/H+-antiporter-NhaA	unknown	unknown	gnl|CDD|184855
NC_016582.1|WP_014178402.1|7083879_7084785_+|NUDIX-hydrolase	unknown	unknown	gnl|CDD|239518
NC_016582.1|WP_014178414.1|7100534_7101356_+|hypothetical-protein	unknown	unknown	gnl|CDD|225718
NC_016582.1|WP_014178406.1|7088438_7089638_+|MarP-family-serine-protease	unknown	unknown	gnl|CDD|367140
NC_016582.1|WP_043487366.1|7098134_7099439_+|lipoprotein	unknown	unknown	gnl|CDD|200598
NC_016582.1|WP_106436402.1|7109002_7110385_-|cell-division-protein-FtsK	unknown	unknown	gnl|CDD|224588
NC_016582.1|WP_014178408.1|7091025_7091487_-|phage-holin-family-protein	unknown	unknown	gnl|CDD|377816
NC_016582.1|WP_014178413.1|7099419_7100424_-|ATP-binding-protein	unknown	unknown	gnl|CDD|349754
NC_016582.1|WP_014178419.1|7106623_7108105_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_158104682.1|7104848_7106417_+|recombinase-family-protein	unknown	unknown	gnl|CDD|214861
NC_016582.1|WP_014178410.1|7093289_7095251_-|acetate--CoA-ligase	unknown	unknown	gnl|CDD|234677
NC_016582.1|WP_014178417.1|7104114_7104738_+|Flp-pilus-assembly-complex-ATPase-component-TadA	unknown	unknown	gnl|CDD|200328
NC_016582.1|WP_014178407.1|7090102_7091029_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_016582.1|WP_014178420.1|7108242_7108956_-|DUF2637-domain-containing-protein	unknown	unknown	gnl|CDD|237030
NC_016582.1|WP_043491038.1|7087760_7088426_+|CoA-pyrophosphatase	unknown	unknown	gnl|CDD|239518
NC_016582.1|WP_003981529.1|7085689_7086364_-|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223736
NC_016582.1|WP_014178403.1|7084784_7085615_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293836
NC_016582.1|WP_014178415.1|7101700_7102537_-|HAD-family-hydrolase	unknown	unknown	gnl|CDD|319796

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014178401.1|7082432_7083800_+|RICIN-domain-containing-protein	gnl|CDD|379501	pfam14200, RicinB_lectin_2, Ricin-type beta-trefoil lectin domain-like.	9.68291e-08
NC_016582.1|WP_014178416.1|7103005_7104118_+|septum-formation-initiator	gnl|CDD|274798	TIGR03815, CpaE_hom_Actino, helicase/secretion neighborhood CpaE-like protein. Members of this protein family belong to the MinD/ParA family of P-loop NTPases, and in particular show homology to the CpaE family of pilus assembly proteins (see ). Nearly all members are found, not only in a gene context consistent with pilus biogenesis or a pilus-like secretion apparatus, but also near a DEAD/DEAH-box helicase, suggesting an involvement in DNA transfer activity. The model describes a clade restricted to the Actinobacteria.	4.4936e-86
NC_016582.1|WP_014178409.1|7091621_7093013_-|Na+/H+-antiporter-NhaA	gnl|CDD|184855	PRK14853, nhaA, pH-dependent sodium/proton antiporter; Provisional.	0
NC_016582.1|WP_014178402.1|7083879_7084785_+|NUDIX-hydrolase	gnl|CDD|239518	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.	0.000265705
NC_016582.1|WP_014178414.1|7100534_7101356_+|hypothetical-protein	gnl|CDD|225718	COG3177, COG3177, Fic family protein [Function unknown].	0.00432863
NC_016582.1|WP_014178406.1|7088438_7089638_+|MarP-family-serine-protease	gnl|CDD|367140	pfam02674, Colicin_V, Colicin V production protein. Colicin V production protein is required in E. Coli for colicin V production from plasmid pColV-K30. This protein is coded for in the purF operon.	4.1197e-21
NC_016582.1|WP_043487366.1|7098134_7099439_+|lipoprotein	gnl|CDD|200598	cd10976, CE4_CDA_like_3, Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins. The family includes many uncharacterized bacterial hypothetical proteins that show high sequence similarity to insect chitin deacetylase-like proteins. Chitin deacetylases (CDAs, EC 3.5.1.41) are secreted metalloproteins belonging to a family of extracellular chitin-modifying enzymes that catalyze the N-deacetylation of chitin, a beta-1,4-linked N-acetylglucosamine polymer, to form chitosan, a polymer of beta-(1,4)-linked d-glucosamine residues.	7.77558e-135
NC_016582.1|WP_106436402.1|7109002_7110385_-|cell-division-protein-FtsK	gnl|CDD|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	9.08521e-09
NC_016582.1|WP_014178408.1|7091025_7091487_-|phage-holin-family-protein	gnl|CDD|377816	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III. Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.	1.15178e-18
NC_016582.1|WP_014178413.1|7099419_7100424_-|ATP-binding-protein	gnl|CDD|349754	cd02034, CooC1, accessory protein CooC1. The accessory protein CooC1, a nickel-binding ATPase, participates in the incorporation of nickel into the complex active site ([Ni-4Fe-4S]) cluster of Ni,Fe-dependent carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible oxidation of CO to CO2. CODH contains a nickel-iron-sulfur cluster (C-center) and an iron-sulfur cluster (B-center). CO oxidation occurs at the C-center. Three accessory proteins encoded by cooCTJ genes are involved in nickel incorporation into a nickel site. CooC functions as a nickel insertase that mobilizes nickel to apoCODH using energy released from ATP hydrolysis. CooC is a homodimer and has NTPase activities. Mutation at the P-loop abolishs its function.	2.0755e-31
NC_016582.1|WP_014178420.1|7108242_7108956_-|DUF2637-domain-containing-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	2.47245e-08
NC_016582.1|WP_158104682.1|7104848_7106417_+|recombinase-family-protein	gnl|CDD|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	4.29659e-19
NC_016582.1|WP_014178410.1|7093289_7095251_-|acetate--CoA-ligase	gnl|CDD|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NC_016582.1|WP_014178417.1|7104114_7104738_+|Flp-pilus-assembly-complex-ATPase-component-TadA	gnl|CDD|200328	TIGR03819, heli_sec_ATPase, helicase/secretion neighborhood ATPase. Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.	2.30677e-78
NC_016582.1|WP_014178407.1|7090102_7091029_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	4.78355e-26
NC_016582.1|WP_043491038.1|7087760_7088426_+|CoA-pyrophosphatase	gnl|CDD|239518	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.	9.96468e-53
NC_016582.1|WP_003981529.1|7085689_7086364_-|Crp/Fnr-family-transcriptional-regulator	gnl|CDD|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	4.10969e-52
NC_016582.1|WP_014178403.1|7084784_7085615_+|MBL-fold-metallo-hydrolase	gnl|CDD|293836	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	4.73641e-77
NC_016582.1|WP_014178415.1|7101700_7102537_-|HAD-family-hydrolase	gnl|CDD|319796	cd02612, HAD_PGPPase, phosphatidylglycerol-phosphate phosphatase, similar to Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C. This family includes Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C, PgpC (previously named yfhB) which catalyzes the dephosphorylation of phosphatidylglycerol-phosphate (PGP) to phosphatidylglycerol (PG). This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.28431e-64

Protein sequences

>NC_016582.1|WP_014178410.1|7093289_7095251_-|acetate--CoA-ligase
MSNESLANLLREERRFAPPADLAANANVTAEAYERAKADRLGFWAEQARRLTWAAEPTETLDWSNPPFAKWFADGKLNVAYNCVDRHVENGLGDRVAIHFEGEPGDTRSVTYAELQREVSKAAHALTELGVRTGDRVAIYLPMIPETVVAMLACARIGAPHSVVFGGFSADALATRIEDADARVVITADGGYRRGKPSALKPAVDEALTRPGTENVGNVLVVRRTGQEVAWAEGRDVWWHELVDRQPEQHTPEAFDAEHPLFILYTSGTTGKPKGILHTTGGYLTQVSYTHHAVFDLKPESDVYWCTADVGWVTGHSYIVYGPLSNGATQVLYEGTPDTPHQGRWWEIVQKYGVTILYTAPTAIRACMKWGDDIPAKFDLSSLRILGSVGEPINPEAWVWYRKHIGADKTPVVDTWWQTETGGMMISPLPGVTETKPGSAQIPLPGISATVIDDDANEVPDGSGGYLVLTEPWPSMLRTIWGDDQRYLDTYWSRFANRYFAGDGAKKDDDGDIWLLGRVDDVMLVSGHNISTTEVESALVSHPKVAEAAVVGATDPQTTQAICAFVILRGGAAEEDGLVEELRAHVSKHLGPIAKPKRILPVAELPKTRSGKIMRRLLRDVAENRTLGDVTTLTDSSVMELIQSKLPSAASED
>NC_016582.1|WP_014178409.1|7091621_7093013_-|Na+/H+-antiporter-NhaA
MAAPIRRKFLGRLSLPERTFVTDALRTETVGGIILLVAAIAALFLANTPLSGIYQDVRDFSFGPDALHLRLSIDSWAADGLLTIFFFVAGIELKRELIAGELRDRRAAALPVMAAICGMAMPALVYVAVGAAGGGNLKGWAVPTATDIAFALAVLAVIGTALPAALRAFLLTLAVVDDLGAILIIAIFYTTHIDFVALGLAFAGLVVFWTLHRKGIRGAYIYVPLAFVIWALMHASGVHATIAGVAMGLMLRCTVREGEERSPAERIEHRVRPLSAGLAVPLFALFAAGVPVSGEAIGQVFSRPETLGVVLGLVVGKTIGVFGGSWLAARFTKAELNEDLAWADVFAIASLAGIGFTVSLLIGELAFPADPTLAAEVKAAVLIGSLLAAVVSGVLLKMRNNTYRQLCEEEERDEDQDGIPDIYELDSPAYHLRMAAIHEAKAAEHRRLAEVAAASDSGDDGPA
>NC_016582.1|WP_014178408.1|7091025_7091487_-|phage-holin-family-protein
MSAADDGGNRSLGQLVATATTELSALVHDEIALAKAEFRDSARRTLFGSGAAIVAGVLLLFSLPVLSFALAYGLRAWTGLGLAWCFLIVGGIYWLIAGILGVFALAKFKRVKAPKKSVASAKETAAVLGSVKPHPRAAANGGRPARDVTRSTA
>NC_016582.1|WP_014178407.1|7090102_7091029_-|alpha/beta-hydrolase
MTAPDTSASVVRLDGPWTHRDVAANGARFHIAELGDGPLVLLLHGFPQFWWAWRHQLTALAEAGFRAVAMDLRGVGGSDRTPRGYDPANLALDITGVVRSLGEPDAALVGHDLGGYLAWTAAVMRPKLVRRLAVASMPHPRRWRSAMLRDVKQSAASSYVWGFQRPWLPERQLTADDGALVGRLIRDWSGPRLPEDQAVEIYRRAMTIPSTAHCSIEPYRWMVRSLARPDGFQFNRRMRRPVRVPTLHLHGSLDPVMRTRSAAGSGEYVEAPYRWRLFDGLGHFPHEEDPVAFSTELINWLKDPEPDR
>NC_016582.1|WP_014178406.1|7088438_7089638_+|MarP-family-serine-protease
MNVLDILLLLAAVWFAVVGYRQGFVVGVLSVIGFIGGGLAAVYLLPVIWDGTTDQASPGTFGAVMAVVLVIVFASVGQAATTHLGNKLRRHITWSPARALDATGGALVNVMAMLLVAWLIGYYLAGSSLPTVSKEVNNSKVLFGVSRVVPDEATTWFSDFRSVLAQNGFPQVFSPFSNEPITSVPAPDPALASSPVATNAKQSIVKVVGTAPSCGKVLEGSGFVFARHRVMTNAHVVGGVDHPTVQIGGEGRLYEARVVLYDWKRDIAVLDVPSLNAPALKFAEGDARSGDGAIVAGFPENGAFDVRAARVRDRIEAKGPDIYHDGNVHRDVYSLFATVRQGNSGGPLLTPQGRVYGVVFAKSLDNADTGYALTADEVRKDAEQGRTAQAPVDTKGCAL
>NC_016582.1|WP_043491038.1|7087760_7088426_+|CoA-pyrophosphatase
MAGVTSDGLPEWLMPVARAAETVEARQLSRFLPPARGGGRPSAVLVLFGEGERGPELLLLERAGSLRSHAGQPSFPGGALDPEDGDPEGAGPVSAALREAEEETGLDPAGVQLFAVLPRLYIPVSGFVVTPVLGWWRKPSPIRPVDPAETARVFTVPVADLTDPAHRATTVHPSGHTGPCFLVEGALVWGFTAGVIDRILHYAGWERPWNRDNRVPLDWRA
>NC_016582.1|WP_003981529.1|7085689_7086364_-|Crp/Fnr-family-transcriptional-regulator
MDDVLRRAPLFAALDDEQAAELRASMGEVTLARGDALFHEGDPGDRLYVVTEGKVKLHRTSPDGRENMLAVLGPGELIGELSLFDPGPRTATATALTEVKLLGLGHGDLQPWLNARPEVATALLRAVARRLRKTNDQMSDLVFSDVPGRVARALLDLSRRFGVQSEEGIHVVHDLTQEELAQLVGASRETVNKALADFAGRGWLRLEARAVILLDVERLAKRSR
>NC_016582.1|WP_014178403.1|7084784_7085615_+|MBL-fold-metallo-hydrolase
MTYGASLPGQPRGGAIGGPATDRAVCVLAPNPSPMTLDGTNTWIVSEPDSDLAVVIDPGPLDDAHLKDVLAAAEQAGKRVALTLLTHGHPDHAEGAARFAELTRTRVRALDPALRLGGEGLGAGDVITTGGLELRVVPTPGHTADSLSFHLPADAAVLTGDTVLGRGTTVVAHPDGRLGDYLDSLRRLRSLTVDDGVSTVLPGHGPVLNDARGAMEYYLAHRANRLAQVETAVESGYRTPSEVVAHVYADVDRSLWPAAELSVRAQLEYLGEHGLI
>NC_016582.1|WP_014178402.1|7083879_7084785_+|NUDIX-hydrolase
MSTTNGQWYPPDWPERIRRLAVGELTPVTPRRAATVLLLRDGAEGPAVHMLRRRTSMAFAAGAYAYPGGSVDPRDERGMAWAGPSRREWARRLGLSADDETAAQAIVCAAVRETFEEAGVLLAGPTPHTVVADTTGEEWDADRAALVARELSFADFLDRRGLVLRSDLLGCWARWITPEFEPRRYDTWFFVAALPHGQRTRNASTEADHTVWIRPAEAAAGYDRGELLMMPPTIATLRELEPYGAVADALAAAPDRDLTPVLARARLEEGQVVLSWPGHDEFTKHIPTGPTGPTGSTGGAT
>NC_016582.1|WP_014178401.1|7082432_7083800_+|RICIN-domain-containing-protein
METGPDPKAARTAAEFVVAMRQLRSWADLSYRQLERNAEAAGDVLPRATISGALSRDDLPREQLLAAFVKACGGDEETAAVWLAARRRLSIAGSGAASASTEPGVPASAPASDGADASVAASEAAPERDTSDATAGHAPTPAPAPVPAHAAETRPGGPTPPDPDERSHEISPPAEVTEVLASGEGPGPGPGEPTSGSAWRRRYLPTLAVGLSAAVGVLLLAYWPFSGSGGGPDARPGASSGSSGGGSSKGADAPSGASDTSETPDTSETPATKEPVADDTPTTSPTRDASSSKPEPTATGAASKPRLPAAGLTRIHPVSAPGLCLTEGKERKTGRAEIAAQMPCADVPLPRVSLDAVGDGVYRIQWDHPGEGKGLGCLAVDDNAMGSGALLAPRSPCTDADNMKFRLEPSHGGFRLRPVHSGLCIGILPPRTEGAEAIQNTCTGEANQAFRFSAS
>NC_016582.1|WP_043487366.1|7098134_7099439_+|lipoprotein
MRPRRNVTAGLAVMAVLATLANCTGNSHDSQRSGNPGQPRTDRDAQRNGPAVPKHPKLGGKQGRLIGDGSTSYTGPQPGQLRPRRLKPGDKPPQFVVFSWDGAGQDGQKLFSRFRAVGRKYDATMTYFLSGVYMLPAKKRDLYDPPRHSRGSSAIGFNDIKGVKDTVEQLGAAWLEGNEIGTHFNGHFCGPDDGVGTWSPKEWIDETRQAVSFVKHWKTNTGQRDGEPLPFDYGKELVGGRAPCLEGQKNLIKAGKKMGFRYDASSVGGRQVWPKKIHGIWDFPLQEIPVPGHSFETLSMDYNFLANQSGTTKGDPSKRAAWGKQMRGGLRAAFRRAYKGNRAPLFIGNHFESWNGGTYMNAVEDTIKKVCPKKGVRCVTFKQLADWLDAQDPGVLRRLRKLDVGKRPKGGWAGFLAAEPASTHSAQPVKRKRK
>NC_016582.1|WP_014178413.1|7099419_7100424_-|ATP-binding-protein
MKIAFVGKGGSGKTTLSSLFIRHLAATGAPVMAVDADINQHLGVALGLDEPEAAALPAMGAHLPLIKDYLRGTNPRISGADTMIKTTPPGEGSRLLRIDEDNPVYEACARTVGLDSGQVRLMVTGPFTESDLGVACYHSKVGAIELCLNHLVDGRDEFVVVDMTAGSDSFASGLFTRFDMTFLVAEPTRKGVAVYRQYKEYAADFDVALRVVGNKVQGPEDLAFLRAEVGDDLLVTVGHSDWVRAMERGRPPRFEKLEEVNRRALRTLYEAADASYERRDWRRYSRQMVHFHLRNAESWGNEKTGADLAAQVDPAFMLGESVLAGRPAATSASA
>NC_016582.1|WP_014178414.1|7100534_7101356_+|hypothetical-protein
MSTTADPLAALAALPGVTDSVDAVRDAVDRVYGHRVMRRRSNEVTSEAALRGARGSAALAGADWALEELRRRSDFGSEGEPRTVGAALRLTAEAGQLLSVWRQSPLRVLARLHLVAAGGTEVADTVGRPRLAGEPVEEPLIELALPDADEVAGRLDGLARLLLAGSQAPALVTAAVVHGELLALRPFGSYNGLVARAAERIVLVGSGLDPKSICAAEVGHAELGAAAYAEALKGYVSGTPEGMAAWIAQCGRAVELGARESTAVCEALQRGAA
>NC_016582.1|WP_014178415.1|7101700_7102537_-|HAD-family-hydrolase
MLGVVENHSLPRTAAFFDLDKTVIAKSSTLTFSKSFYQGGLINRRAVLRTAYAQFVFLAGGADHEQMERMREYLSALCRGWNVEQVREIVAETLHDLIDPIIYDEAASLIEEHHTAGRDVVIVSTSGAEVVEPIGELLGADRVVATRMVVENGVFTGEVEYYAYGPTKAEAIAELAESEGYDLSRCYAYSDSATDLPMLESVGHPHAVNPGRALRREAAARGWPILSFNKPVRLKQRVPSLSMPPRPVLAVVAAVGAAAATAGLMWYASRRRAPYARI
>NC_016582.1|WP_014178416.1|7103005_7104118_+|septum-formation-initiator
MAGSITPNRPAADGRQRRPLIVTEDEELLDDLLRLCAAAGAEPEVVHGLPARRGSWEGAPLILVGDDAAARLRGGTRREGVLLIGRDLDDHGIWQRAVALGADNVAFLPDAETWLVDRIADVAEGVGRQALTIGVVGGRGGAGASTLACALAVTAARAGRRTMLIDGDPLGGGLDVLLGGEGAEGLRWPAFAESRGRVAGSALEESLPELHSLRVLSWDRGQSAAIAPSAMRAVLAAARRRGGVVVVDLPRRVDDTVAEALDQLDLGLLVVPAELRAVAAAHRVASTVGMVLRDLRAVVRGPCGPGLDDEEIARLLDLPLAGELPPEPGLPDALDGGEPPGGSARGPLARFCSAFWGRVLADAEQQGGGA
>NC_016582.1|WP_014178417.1|7104114_7104738_+|Flp-pilus-assembly-complex-ATPase-component-TadA
MSVNTSVTWRERGGAGVESPELLDAVRLRLARSGAEPTPARVAAALREEGRLLGDTEVLSVVAALRSELVGTGPLEPLLAAPDVTDVLVTAPDEVWVDRGAGLERTDVAFTDAAAVRRLAQRLAAVAGRRLDDARPWVDARLPDGTRLHAVLPPVAVGSTCLSLRVVRPRAFSLEELVAAGTVPPGGQELLRAMLDARLSYLISGGT
>NC_016582.1|WP_158104682.1|7104848_7106417_+|recombinase-family-protein
MISPELQEHTGRKYAADIGAVIVDVVYDLDLSGADFAKRKIGSIIARVSNDEADGVLVYRWDRFGRNIELSLTNLRMLEGMGGVAKSATEQFDTSTAAGRFARTNMLGVAEFQRDLIGENWMSTHARRIRRGLPHHGAPRFGYWYCDTCPMPEPRSPRGVRRERQRRQTCEKCKAGIQIPRPVYGDALAYAWEEYAEGKPLHRAAHELKLEGLRTYSGKIITDKTLLAAMDTGFGAGYVRVTPGARSWADELPESAVESTGIHKLDRFIWIPGAHEQVIKSEDTWNAYLERRRAGKRIASHKTRAKYPASGLVFCIDCGDKSGVPMRAGASRGAGGGLYLTWRCGKIDTGECNHSNASREAVDAVILEWLQKRAKDDGTAQAVAQEAVKANAAPVGQQDGPDHWQAEISRLKTLKKNLIRMRAADEIDQAEFIEQRDELAEEIATADAKLKRAKKRKTPSVPKREVFQGLMKEWPHMDDDTKRAALKKVIWRINASRGEFHDHDRYTIIPLWERPEPEEVGR
>NC_016582.1|WP_014178419.1|7106623_7108105_-|hypothetical-protein
MNRPLDLRHVASLALRDLIELAHLPDFDRVHDQISRVRGCTRPVQLVGTTQTLDATTNTVLRSYSTADEPTGRLLTACGNRRSSRCPACSRVYAADTYHLIKAGLSGGKDVAETVRDHPRAFVTLTAPSFGPVHNCKTDAGKLRPCRCGAHHAEDDPALGTPLTPAAYDYTGAVLWNAHAGQLWARFTTYLRRALAEHLDMTQKALNAALRVSFAKVAEYQKRGLVHFHAVIRFDGPDGHTTPPPAWATFDALSAAVGLAVKRARLTVESDAVGERVIAWGGRFKVDPISALGDGELTDARVAEYTDAKVAGYVAKYATKNAEGAGTVDRSLRCSHCAGRGYQCGPDGFRDLCGQCEGTGQSEPLADLPVHSHVRQMIRTAWALGHLPEFADLKLWKWAHMLGFRGHFSSKSRRYSTTLGALRDVRRAWRTAQARPAGAPETSEETTLVLSHWQYLASGYSPGEELIAAQVRHDRAQARDMAERVKTEGEVWR
>NC_016582.1|WP_014178420.1|7108242_7108956_-|DUF2637-domain-containing-protein
MSEDRITQRTVTVVMAIIAALAFVFSFGNVWALALRLGVPRPIAPLIAPMVDLSVVGLLVALRYLSLRGIAAEQIKGATRLMHLSGLLTLALNIAEPLVAKHYGRAAVDAVAPLLLLGWGAVGPQLLRHFHAVTHTEAPTPAATPDPAPAETAPAPVTEPDSAPAPATAPTPEPAAASAPPAPAAPPAVTVPVPLLNAARTIADTYQADHGAPITPAQLRTRLGVALPLATAAHAQL
>NC_016582.1|WP_106436402.1|7109002_7110385_-|cell-division-protein-FtsK
MTVGEVIGLAPALAGAALALSGIWAVWWVVRYVRADKMTRASIRQAIRVRRGWRRLAPMAGLSVTDKTPPAAVIVAPDGKVPKPRVLIPKIKVRADRYGVVVRAVCLPKVSLAEFQRAAPYLADAWRCTRVSVLPDRPGQLVIRGVRVDPLIVPTEHIPTGEVPEELAVWGLGVDEYAQPIDVSLSDVPGVTVAGLPGFGKTSLVNKFICDTAPSDAIQYAVADGKVTSSHEGDYADLAQRMFAFVGDDLEEANALFKRLVKLRRDRSASIRAVLGVKNMWHLGPSATWPLTVLIVDEAHTYFRDHKGSDPQTKKLAALAADNARLVEDLVKKGRSVGILVIIATQKATGDAIPTFIRDVCPVGLSFAQKTAEAAVVALGEDIRNWPDANPTALQDPVYVGVASMAHQGRPGFTRIRTPYVADDDAARIAADTAHLTRDPAELLDEQLTSPTSAPVLLAK

Crispr_ID: NC_016582_14

• CRISPR_ID: NC_016582_14
• CRISPR_location: 7328077-7328174
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_14

Consensus_repeat	Method
GGCGAGCACGACAACGGCCGCGAGCACGAGAA	CRISPRCasFinder

spacers of NC_016582_14

>14.1|7328109|34|NC_016582|CRISPRCasFinder
CAAGCGCGAGAACAAGGGCGAGCACGACAACGGC

CRISPR arrays and Neighbor proteins around NC_016582_14

CRISPR arrays

The CRISPR arrays of NC_016582_14

>merge|NC_016582|14|7328077-7328174|CRISPRCasFinder
AACGGCCATCACAACGGCCGTGACCATGAGAACAAGCGCGAGAACAAGGGCGAGCACGACAACGGCCGCGAGCACGAGAAGAAGAACGAGCACGAGAA

>NC_016582|14|13|7328077-7328174|CRISPRCasFinder
AACGGCCATCACAACGGCCGTGACCATGAGAA	CAAGCGCGAGAACAAGGGCGAGCACGACAACGGC
CGCGAGCACGAGAAGAAGAACGAGCACGAGAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014178617.1|7329512_7331807_+|hypothetical-protein	unknown	unknown	gnl|CDD|274571
NC_016582.1|WP_014178607.1|7317417_7319226_-|arginine--tRNA-ligase	unknown	unknown	gnl|CDD|215160
NC_016582.1|WP_014178624.1|7338595_7340092_-|MFS-transporter	unknown	unknown	gnl|CDD|341047
NC_016582.1|WP_106436409.1|7316629_7317289_-|Uma2-family-endonuclease	unknown	unknown	gnl|CDD|368559
NC_016582.1|WP_014178621.1|7334992_7337185_-|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|376917
NC_016582.1|WP_043487394.1|7319360_7321130_+|lysine--tRNA-ligase	unknown	unknown	gnl|CDD|234829
NC_016582.1|WP_170061318.1|7342071_7342812_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|366444
NC_016582.1|WP_014178613.1|7326422_7326833_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014178618.1|7331819_7332887_-|C40-family-peptidase	unknown	unknown	gnl|CDD|366353
NC_016582.1|WP_193383799.1|7323681_7324608_-|DUF3558-domain-containing-protein	unknown	unknown	gnl|CDD|215343
NC_016582.1|WP_014178614.1|7326908_7327664_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187604
NC_016582.1|WP_043487395.1|7321240_7322707_-|DUF2637-domain-containing-protein	unknown	unknown	gnl|CDD|378511
NC_016582.1|WP_014178612.1|7324847_7326041_+|RtcB-family-protein	unknown	unknown	gnl|CDD|376465
NC_016582.1|WP_014178620.1|7333387_7334986_-|poly-gamma-glutamate-synthase-PgsB	unknown	unknown	gnl|CDD|188527
NC_016582.1|WP_143675830.1|7337496_7338555_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014178605.1|7315090_7316647_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|312032
NC_016582.1|WP_014178616.1|7329046_7329382_-|YnfA-family-protein	unknown	unknown	gnl|CDD|235016
NC_016582.1|WP_014178619.1|7332908_7333391_-|poly-gamma-glutamate-biosynthesis-protein-PgsC/CapC	unknown	unknown	gnl|CDD|379469
NC_016582.1|WP_055413990.1|7322817_7323558_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_043487396.1|7341545_7342049_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014178617.1|7329512_7331807_+|hypothetical-protein	gnl|CDD|274571	TIGR03420, DnaA_homol_Hda, DnaA regulatory inactivator Hda. Members of this protein family are Hda (Homologous to DnaA). These proteins are about half the length of DnaA and homologous over length of Hda. In the model species Escherichia coli, the initiation of DNA replication requires DnaA bound to ATP rather than ADP; Hda helps facilitate the conversion of DnaA-ATP to DnaA-ADP. [DNA metabolism, DNA replication, recombination, and repair].	6.64266e-06
NC_016582.1|WP_014178607.1|7317417_7319226_-|arginine--tRNA-ligase	gnl|CDD|215160	PLN02286, PLN02286, arginine-tRNA ligase.	0
NC_016582.1|WP_014178624.1|7338595_7340092_-|MFS-transporter	gnl|CDD|341047	cd17504, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.47283e-52
NC_016582.1|WP_106436409.1|7316629_7317289_-|Uma2-family-endonuclease	gnl|CDD|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	1.08835e-24
NC_016582.1|WP_014178621.1|7334992_7337185_-|HAMP-domain-containing-protein	gnl|CDD|376917	pfam02743, dCache_1, Cache domain. Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains.	1.45886e-07
NC_016582.1|WP_043487394.1|7319360_7321130_+|lysine--tRNA-ligase	gnl|CDD|234829	PRK00750, lysK, lysyl-tRNA synthetase; Reviewed.	0
NC_016582.1|WP_014178619.1|7332908_7333391_-|poly-gamma-glutamate-biosynthesis-protein-PgsC/CapC	gnl|CDD|379469	pfam14102, Caps_synth_CapC, Capsule biosynthesis CapC. This family of proteins play a role in capsule biosynthesis. They are essential for gamma-polyglutamic acid (PGA) production.	1.27148e-26
NC_016582.1|WP_014178618.1|7331819_7332887_-|C40-family-peptidase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	8.03804e-08
NC_016582.1|WP_193383799.1|7323681_7324608_-|DUF3558-domain-containing-protein	gnl|CDD|215343	PLN02638, PLN02638, cellulose synthase A (UDP-forming), catalytic subunit.	0.000323346
NC_016582.1|WP_014178614.1|7326908_7327664_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187604	cd05346, SDR_c5, classical (c) SDR, subgroup 5. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.96583e-89
NC_016582.1|WP_043487395.1|7321240_7322707_-|DUF2637-domain-containing-protein	gnl|CDD|378511	pfam10935, DUF2637, Protein of unknown function (DUF2637). This family of proteins has no known function.	7.64947e-37
NC_016582.1|WP_014178612.1|7324847_7326041_+|RtcB-family-protein	gnl|CDD|376465	pfam01139, RtcB, tRNA-splicing ligase RtcB. This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyze the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage.	1.83939e-177
NC_016582.1|WP_014178620.1|7333387_7334986_-|poly-gamma-glutamate-synthase-PgsB	gnl|CDD|188527	TIGR04012, poly_gGlu_PgsB, poly-gamma-glutamate synthase PgsB/CapB. Of four genes commonly found to be involved in biosynthesis and export of poly-gamma-glutamate, pgsB(capB) and pgsC(capC) are found to be involved in the synthesis per se. Members of this family are designated PgsB, a nomeclature that covers both cases in which the poly-gamma-glutamate is secreted and those in which it is retained to form capsular material.PgsB has been shown to have poly-gamma-glutamate activity by itself but is bound tightly by PgsC (TIGR04011). [Cell envelope, Other].	6.67975e-124
NC_016582.1|WP_014178605.1|7315090_7316647_+|alpha/beta-hydrolase	gnl|CDD|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	5.46092e-22
NC_016582.1|WP_014178616.1|7329046_7329382_-|YnfA-family-protein	gnl|CDD|235016	PRK02237, PRK02237, YnfA family protein.	2.05577e-48
NC_016582.1|WP_170061318.1|7342071_7342812_-|ABC-transporter-permease	gnl|CDD|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	1.70084e-11
NC_016582.1|WP_043487396.1|7341545_7342049_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.43805e-20

Protein sequences

>NC_016582.1|WP_014178614.1|7326908_7327664_-|SDR-family-NAD(P)-dependent-oxidoreductase
MTTRTAVVTGASSGIGAATARRLAAAGFRVVLAARRKERIEALAAELTEAGHEAETYPLDVTDRAAVDAFAAALDRCDVLVNNAGGALGTEPVATADPADWRAMYEVNVVGVLNVTQALLPALIASGDGTVVVLSSTAGHIAYEGGGGYVAAKHGAHAIAATLRLELCGDPVRVIEIAPGMVRTDEFALNRYRGDEDKAAAVYEGVAEPLTADDVADTVEWAVTRPSHVNIDLMVIRPRAQAAQHKVHRER
>NC_016582.1|WP_014178613.1|7326422_7326833_+|hypothetical-protein
MRSIARAATAVGAAALIVGGLSAAPASAADGRTCVSNQHPTLDVWTGRGCFVGNGDDIEATDLYADGQRTVVDWYTDYGREGECDNALGTGWTVTCDYDMTETGRIKFRVCARSGGINRDCTDWTGWISIRTGEAA
>NC_016582.1|WP_014178612.1|7324847_7326041_+|RtcB-family-protein
MSYVELPGARVPIRMWTDPATVEGVAMQQLRNVATLPWIKGLAVMPDVHYGKGATVGSVIAMQGAVCPAAVGVDIGCGMSAVRTSLTAEDLPGDLSRLRSRIERAIPVGRGMHEDPVDPGQLYGFSAPGWDDFWGRFGEVAEAVRFRQERAVKQMGSLGSGNHFIEFCLDESGSVWLMLHSGSRNIGKELAEYHIGEARKLPHNQGLVDHDLAVFIADTPQMAAYRHDLFWAQEYAKYNRSVMMALFQDVVRKEFKKAKPTFEPVISCHHNYVAEERYEGMDLLVTRKGAIRAGSGDYGIIPGSMGTGSYIVKGLGNAASFNSASHGAGRKMSRNAAKKRFSTRDLEEQTRGVECRKDAGVVDEIPSAYKPIEKVIDQQRDLVEVVAKLKQLVCVKG
>NC_016582.1|WP_193383799.1|7323681_7324608_-|DUF3558-domain-containing-protein
MLTTVLAAIGLSGCTSTASHAGLDDGKPGDSGAPVAAAPGKYRTLPEACGAVDPKTLRNLLPGAEEDDPVYDGQATVTYDTNRRVGCRWKLETSSGTRYLTLDFERVVSYDPTVSDDDQAKERYEKKAAASHVPGASETPSAPSGSSGSSGSESGSGSPGKDTPKGSTSAPSDSGKDDSGKDDSGKDGSGEDGSKTEGAKVEGATPHASGTDEPGTRGTDASGDADASETAAPRRLDDLADDAFLDDQLITSDSGIHRDVTVVFRSSNVIATIEYDQWSTNKKHIPSSEELQVNAEDLAQELTGRLNE
>NC_016582.1|WP_055413990.1|7322817_7323558_-|hypothetical-protein
MHRTAPRLARIFVSAAVPVVLVAGCSSGSDKDSKDSASPSKSATPSPTPTVAAAKYSKLPAVCPTLSAKTIDELVPKAQSKKGKELPSADANQSASCLWTGLNGFKYRQLSVSLKLFRSEVSLGSGDKRAQAYAADQAQKAAASDGAKNAKTGQVSGIGDAATTVSTESKKDGDEFRNQTIVVRTANVVLTLEYNGAGYEDEKTPDPKTLLKDAQTGAKDVVASIEKDAEKSGASSAGSGSSSSAA
>NC_016582.1|WP_043487395.1|7321240_7322707_-|DUF2637-domain-containing-protein
MAAMQLTRTHRILIGVVVTGAVVIAAIGFAGSYAAVRDLAHDKGFGAFANVLPIGIDAGIVVLLALDLLLTWLRIPFPLLRQTAWLLTAATIAFNGAAAWPDPLGVGMHAVIPILFVVSVEAARHAIGRIADITADRHMESVRVARWLLAPVPTFRLWRRMKLWELRSYDQVIKLEQDRLVYRARLRARYGRAWRRKAPVESLMPLRLARYGVPLAETAPAGLAAAGLDPAELAPAPMPAALPYGGGDAGIPRAAGAVVPGAAGANRAAAQERELPMSFPLPVYQQQGYQQPGTPEHDGRAATGFEQQAAGHPAAGQPQTPDEAQQLQQAQQAQEAQQPQTQQPQLDAQAQQQAQQFAAQVDEAQAAGGLTAPVGAGGRVRPLGGQGTSSQVPYVPAQRGLESYGEPEPSEVRVPPVNLPDDMPRDEAYYGAFRQHVTNNGMFPSPYQFGRLLREGYGIPDLSDGDVRRHLEDCKERYKLEMGTESIP
>NC_016582.1|WP_043487394.1|7319360_7321130_+|lysine--tRNA-ligase
MTARKEVPTVAQSTETDWVSRFADEVIAEAERRAPGKPIVCASGLSPSGPIHLGNLREVMTPHLVADEIRRRGYECVHILSWDDYDRYRKVPAGVDPSWAEHIGKPLTSVPAPPGSPYASWAEHFKAPMIEALQELGIEFHGISQTEQYTSGAYREQILHAMRHRGQIDAVLDRYRTKDKDKDKASGGAKKPAKQQQKPVDEAELEAAEGSGAASEDDGSAGGAGYFPYKPYCSVCERDLTTVTSYDDETTEMAYTCACGHGETVRLREHDRGKLVWKVDWPMRWAYEGVVFEPSGVDHSSPGSSFVVGGQIVREVFGGEQPIGPMYAFVGISGMAKMSSSKGGVPTPADALEIMEAPLLRWLYARRRPNQSFKIAFDQEIQRTYDEWDALERKITEGAAQSADVAAYSRATRTASGELPRTPRPLPYRMLASVVDITTGHDEQTLRILSELDPDNPVKSLDETRPRLDRAERWINTQVPAEQRTRVRDEPDTELLASLGETERESLRLLLDGLDTHWSLDGLTTLVYGVPKLQAGLAADAKPTPELKVAQRTFFALLYQLLVGRDTGPRLPTLLLAVGADRVRKLLAA
>NC_016582.1|WP_014178607.1|7317417_7319226_-|arginine--tRNA-ligase
MASVLSLAATVHQRLADALSAALPEAGAADPLLRRSDRADFQANGMLALAKKLKGNPRELAAKVVESLPAGELIADIEVSGPGFLNITVSDEAIVKTLAARAADARLGVPYAESPGTTVVDYAQPNVAKEMHVGHLRSAVIGDAVVRILEFAGEKVVRRHHIGDWGTQFGMLIQYLLEHPHELDHKAATGDQGAGDDKDLAASGEEAMSNLNRLYKAARALFDSDEEFKERSRRRVVDLQAGDAETIALWHRFVDESKIYFYSVFDKLDMDIRDPDVVGESGYNDMLAETCRLLEESGVAVRSEGALCVFFEDVKGPDGNPVPLIVQKSDGGFGYAATDLSAIRDRIQNLQADSLVYVVDARQSLHFKMVFETARRIGWLNEKTHAYQLAFGTVLGKDGKPFKTREGETVRLGDLLDEAIERATAVVREKSKGKIDLTEEEIAERGAQVGIGAVKYADLSTSAARDYKFDLDQMVSLNGDTSVYLQYAYARIQSILRLAGEGQKPVAHPELPLAPAERALGLHLDQFAEILREVAAGYEPHKLAAYLYQLASFYTTFYDKCPVLKAEGGPAQVENRLFLCDLTARTLHQGMDLLGIRTPERL
>NC_016582.1|WP_106436409.1|7316629_7317289_-|Uma2-family-endonuclease
MAEEADRRSDMTLAPEHPCPPVAHITEETTHTTEETTVSLIDIAETVFQNLPGYRPEILGGQLIVTPPADPPHAESLTNLTLAFAALHQGETRVVQAVGIWLPTGEEDYAIPDLAVVDADHRDHMAPYNCIDPAVFRMVFEVTSSNWRDDLDRKPSHYARAGVPVYVIGDRKHGEVIVLTDPHDGEYRTRSVHRPGESFVLPESIGAKVELEVDSLLSE
>NC_016582.1|WP_014178605.1|7315090_7316647_+|alpha/beta-hydrolase
MRIVNAKAAALALALAATTGSLLASTAAADAAAPRSPTPLNWGVCEGTGLDPRQECATLKVPMDYHDPGGDQISLAVSRISSAKPGARRGALLLIPGGPGGSGLSRPSTLGAKLPQTVRDAYDLVSFDPRGVGRSTPVSCGLAHEDLALTRSRPWPAPDGSIADNVATGRRMADACGRNGGPVLKSLSTVSEARDIDRIRQALGEEKLSAWGTSYGTYAGAVYAQMFPEHTDRWVLDSNDDPDPTRVGRGWLANFAVGVEDTFPAFAAYASRPGDHQLADTPDGVRRLFLDLAARLDAHPIPWEGANPPELNGNVLRQQLLDTLYAPSRYADLPGSRYAALAELIRAARDGADLPAPAALPDEAMQNTMASGTATLCNDVSWPKSLPPYAREVAASRTSHPLTAGMPVSVMPCAFWPDELRDKPVRITSDGPSNVLLVQNRRDPATPYSGALKLRRAFGERARMVTADETGHGAYVVNGNACSDGYVTDFLVGGERPERDTFCAAEGDRPAVGSLGQQ
>NC_016582.1|WP_014178616.1|7329046_7329382_-|YnfA-family-protein
MLIARSIALFCLAALFEIGGAWLVWQGVREHRGWAWVGAGIIALGAYGFVATLQPDAEFGRILAAYGGVFVAGSLAWGMVADGYRPDRFDVAGALICLVGVAVIMYSPRGR
>NC_016582.1|WP_014178617.1|7329512_7331807_+|hypothetical-protein
MAGGSGVHVHGDVEGQVVVGDRNVVINAERGSSVTVRSEPPPFARRRARPAGRALPHRVPELLGREGELAALRRWLSQGHPVQIYGPPGIGKSVLLRRFAADAAARGQDVVYLPAAGVPVDDLVQELFQACYEAPDYKPAPAVTQQLMASVHALVAVDEFQGSAEDLTELVAAAPGCDVLVVTAERQEWTEGRALRLDGLLEEPALALLTEELGRPLRGDERAAAAHLIATVRGHPLTLLQAAAALRSARAAGASGAAGRVEPEGAAGPAGLAVDERALAVGVAGGLSDGAGKLLRILCAVEPLPLSPALLSVIAAGPAGPAGPAHPAGATGAAGVDRGAAAELEALRLASSEGGGFRATGRLAPVVAERTGPAQDPAVLAAALVGWARGATRHELAAESAVIRRLLEAAALAGGHEAVRDLARFTAPALARSLRWGSWRQVLGLGAGAARALGAAADLAYFTHEEEARRRALGLAVGVAAGLSFGAGAAAGHLGGPASGHAASQAVSHAAGHGSAAAGKSALSSFAANPVAIGTAAALLVAGGVFVAFASTGGESPRADPTVPITSFAPTPTLTPTSAPTSSAMSTTGLPTATTAVPTATTTTAEPTTGQPTYGSGQCPPVPLAVGSFGPVGAGEQDSKSVTWDSYWECDDAKTLAVSDPTAWRVRATSCPVTQKPGPPRSASGPCVFEVVFSPPASAEPGTTYSAKVTMLDDWGHVAMTLPLSGTTATVGPTGPTGPTDPTDPTGPTGEGPSTQPSEPVPGA
>NC_016582.1|WP_014178618.1|7331819_7332887_-|C40-family-peptidase
MSAKKTSKKRGALHAVTVLALLGASAYLTVELRKEEDSKAPAVQKVTDNPQLENSAEDTGARTWERLKSPERTVLRGSKGQVLATFTDGARTATLKGPSRTFSEPANTTSRVVTEDWVRLMPEPWRQGAEKEQWFKDWFKQNYGSEEDDIFAIAFQYSQGAPIKKDDEGIPYAGDAVFGPFKQDGVDRLEQNDFYDYLGIPYTFRDGTTMQPRKERYRALDCSGFMRMIWGYRARYPLRATNVVGDGLPRTADGMARSTVGADIIKLQGPSPWYQRPANIDVLQPGDLLFFKMDHRTGNHMDHVALYLGVDTDGHRVFISSRKEVNGPTMGDKGGASRIDGNGFYAQLFRSAKRL
>NC_016582.1|WP_014178619.1|7332908_7333391_-|poly-gamma-glutamate-biosynthesis-protein-PgsC/CapC
MIPSVLTPEIAALGIALGLMFSLVCYLTTNLSPGGMITPGWLALTLVEDLQRAAMVIGVTVLTYVCVLLLQRFVILYGKRLFAAVVLTGVLLQATVMIALTVEFPLMYSNQTLGFIVPGLIAYQLVRQPKGPTLLATGSVTLMAYVVLTAGILLGVMPTS
>NC_016582.1|WP_014178620.1|7333387_7334986_-|poly-gamma-glutamate-synthase-PgsB
MLFLYTVLMVCSAILLVAGVVEQRRHFANLDNIPTRVLVNGIRGKSSITRLCAGALRGGDLVTVAKTTGTAARFIHPDATEEPVYRKFGIANVVEQIGIVRRAAAYRPDALVIECMAVMPALQEINQSKLIRSTIGVLCNVREDHLAEMGPTLDDVARSLCRSMPEDGICVTAEKERLHILQEEADARNCRLIYADPETVTDEELRGFSWFTFKENVAIALTVAELLGVERKVALQGMYDAPPDPGVLSVERYRTDEGKRLRFANVFAANDPESTLMNINQLLDLGAINRPLNVVINCRPDRVERNGQMGEIIPDLDPEHVFVIGHPAKSAIDAIPASYRSRAVDLGGDRRDPEEFMAQMLGMLGPDSSLVAIGNIHGQGEVLLEHLAELPADDSPDEPSAGDSVGTPEPAAAPAGAEGIRPATAPVGATAPALPASPAPPEHVDTMQLYAPRIDPYQRYPEAYETRYGQRQPTAQDGQAGPRGYFEPRVPPQPLTADPPLMADPPPAADQPAAAAQPPAEDQQWHSSGEPR
>NC_016582.1|WP_014178621.1|7334992_7337185_-|HAMP-domain-containing-protein
MSLIGGIRPPIAVLSALLLSLAGITALTFGKTENVLVPKAVLTSQQHFAEDGAVALRASLDESVTDLDRTAILFSEGKPVSADAVLDKTGSVYQKWSGTAVIEIKSGKLLAARGETVPLTVIDRTKLSGKDGLKPRLVRLQNGQTRLIALALLSWKGQPQQLLIASSNLKVPGMRLSESRGIGVVDSTGTILSSDGALDSERAQRELKDFATISAKKSRQNPISSKEPGSGGYAGVSGSLTGDASGDRRTVGGYASLAASEPGESTVASGLGLSIVTQVGVTERASQLARPAFGLAAAGALLVIGALAIAVLLGTVQRPLIRLFLESRRLTRGDLARPVTVPRFGEAARIGGALERLRQQLHEESPEGADGASGTDGASGARGGRRLGTRALVAVSAVLLLTWSVPLTLLLNRPSSSVHIPAQVVADQKARTETISDRVRRALNEGHADLSAVAALIGNRTSADDMTAVLDRTIEEHPRYESVYVVSGDGEVLARAGHEPHHSSGERPADQPLKVSGHGGKKPVIRATAPLQGKAGAAVVGEFDIDFVNALLRRDGLGQVRVVDAKGRTIAGNSGYLAFEKMPGHLSPLVDRKQAHAKVQRGDDVRIAAAAPMTGGGVAKVLDWSVVSWQPASRLDIPAYTLQNRTVLVGLLGLTAAAACLGWLHIVVVRPLRALADQAEALADGDRRTVLFPRHHDEVGAVVRSLELIRQQLQGQQRGRDGARSLAGRN
>NC_016582.1|WP_143675830.1|7337496_7338555_+|hypothetical-protein
MRADSSMRADRPRKTTHAARKASSVVRKTSAAARKNPLVLGVVALTAVAALLTTVLALRGSGEDGTTTPKAGIDLERRITDYTARFGADTGYLEPKRADRQAVARAVGLLLDGHRDQAAARLDALDFDLRTITDSATGRRYAEIADRTDTGPTPRGWGRVYVDLSAPAHWSVQIPHPVADARTEQLGVGILRGSPGGVLVLAGAHRDAGVGDAADVAHRRYTVFAAVCAELAERGLPGIQIHGFADDSAPDYDVIASTGRATRESRADARTLANALRARDFEVCRAWVRSCPLEGRTNEQGRAAAAQDSTFLHVEFANAIRTDRREAARAVAAVNVVTARWAKRTPHPGATG
>NC_016582.1|WP_014178624.1|7338595_7340092_-|MFS-transporter
MSDALARPAAGGSAPPRPNAVVAVLAFSGIVVSLMQTLVIPIVPELPKYLDASPSDATWAVTATLLAAAVATPVVGRLGDMLGKRRLLLVSLVLLVSGSVVCALSESLVPMIVGRTLQGLAAAVVPLGISIMRDELPPERLAGSTALMSASLGVGGALGLPAAALIADNFDWHALFWTSAALGAVALALVGMIVPESKVRTGGRFDLAGSLGLSAGLVSLLLAVSKGADWGWTSATTLGLFAAAVVILLSWGAYELRARQPLVDLRTTARRQVLFTNLASIALGFSMFAMSLVLPQLLQLPEQTGYGLGMSMLTTGLVLAPQGLVMMVVSPFSAAVTKAKGPKVTLMIGALIVAAGYGLNIVLMSEVWHLILASCVIGAGVGFTYGSLPALIMGAVPASETAAANSLNALMRSLGTSFASAIAGVILAQMTTGFHGRALPSESGFKVVMAIGAGAALLAFALASFLPRQRAAAAQGAPAAAGPDESAAESAEALGTAS
>NC_016582.1|WP_043487396.1|7341545_7342049_+|MarR-family-transcriptional-regulator
MSTPSSAAGPVSTDVIEIERALTRIAYLAGRARQHERLMALAGLSLDRAAVAILRHIAESEPLRPGVLAVRLSVEASHVTRQLGQLEKGGYVIRVPDPDDRRAQRIQLTDAGLAAVERIREASRRGMSIALADWSAEDLGQLAGLFHRLPADFVKHAEADVDIPPSA
>NC_016582.1|WP_170061318.1|7342071_7342812_-|ABC-transporter-permease
MWHQIRYEQLTFWRNPQSAFFTFVFPVVVMAIFGGLFGSIGKSEFYYGRSALQYYVSTIAAVSVLGSCYSQLAIVLATRRQNGMLKRVRATPLPASGYFAGLLAHCVLVSVVDVLLITAVGRLYGVPLPAAPQWPALAVSLVLGAAAFCALGVAVASLVRNAEAAPSVVQFVLFPLVFISGTYMPIHSALLNGIAGALPVKPFNDALLLAFTTDHTGLPWRDYGVLLLWGVAGAAVAVRRFRWDSR

Crispr_ID: NC_016582_16

• CRISPR_ID: NC_016582_16
• CRISPR_location: 7924693-7924792
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_16

Consensus_repeat	Method
GGCGGGTTCGTGGACGACGGCTACGACG	CRISPRCasFinder

spacers of NC_016582_16

>16.1|7924721|44|NC_016582|CRISPRCasFinder
CGGCCCTTGAGGCGCCTGCCGACCTCGTACAGGCCGAGGAGTCG

CRISPR arrays and Neighbor proteins around NC_016582_16

CRISPR arrays

The CRISPR arrays of NC_016582_16

>merge|NC_016582|16|7924693-7924792|CRISPRCasFinder
CACGGCGTCGTGGCCGACGCCGACGGCCCGGCCCTTGAGGCGCCTGCCGACCTCGTACAGGCCGAGGAGTCGGCCGAGTTGGCGCTGGACGGCCACGGCG

>NC_016582|16|15|7924693-7924792|CRISPRCasFinder
CACGGCGTCGTGGCCGACGCCGACGGCC	CGGCCCTTGAGGCGCCTGCCGACCTCGTACAGGCCGAGGAGTCG
GCCGAGTTGGCGCTGGACGGCCACGGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_106436685.1|7936037_7936631_+|RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|224511
NC_016582.1|WP_014179148.1|7934309_7934933_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014179139.1|7922452_7923352_+|FAD-binding-domain-containing-protein	unknown	unknown	gnl|CDD|366378
NC_016582.1|WP_014179147.1|7933544_7934153_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014179134.1|7916654_7917071_+|hypothetical-protein	unknown	unknown	gnl|CDD|238206
NC_016582.1|WP_014179142.1|7927994_7928747_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NC_016582.1|WP_014179135.1|7917227_7918544_+|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270450
NC_016582.1|WP_014179141.1|7925636_7927964_+|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|132240
NC_016582.1|WP_014179146.1|7932405_7933545_-|peptidoglycan-binding-protein	unknown	unknown	gnl|CDD|366659
NC_016582.1|WP_014179143.1|7928743_7930417_+|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|182539
NC_016582.1|WP_055414007.1|7931635_7932409_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213222
NC_016582.1|WP_078610618.1|7916096_7916390_+|DUF3039-domain-containing-protein	unknown	unknown	gnl|CDD|378609
NC_016582.1|WP_014179131.1|7913773_7915126_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl|CDD|236486
NC_016582.1|WP_014179144.1|7930427_7931639_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|223650
NC_016582.1|WP_043491364.1|7919628_7920489_+|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NC_016582.1|WP_043491358.1|7915365_7915971_+|YqgE/AlgH-family-protein	unknown	unknown	gnl|CDD|234694
NC_016582.1|WP_014179130.1|7913403_7913685_+|HU-family-DNA-binding-protein	unknown	unknown	gnl|CDD|259859
NC_016582.1|WP_014179136.1|7918558_7919581_+|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NC_016582.1|WP_043491366.1|7920497_7922177_+|beta-N-acetylhexosaminidase	unknown	unknown	gnl|CDD|119333
NC_016582.1|WP_014179149.1|7935075_7935918_-|DUF1963-domain-containing-protein	unknown	unknown	gnl|CDD|370378

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_106436685.1|7936037_7936631_+|RNA-polymerase-sigma-factor	gnl|CDD|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	4.93901e-27
NC_016582.1|WP_014179139.1|7922452_7923352_+|FAD-binding-domain-containing-protein	gnl|CDD|366378	pfam00941, FAD_binding_5, FAD binding domain in molybdopterin dehydrogenase.	4.68028e-46
NC_016582.1|WP_014179134.1|7916654_7917071_+|hypothetical-protein	gnl|CDD|238206	cd00338, Ser_Recombinase, Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.	0.00480555
NC_016582.1|WP_014179142.1|7927994_7928747_+|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.108e-78
NC_016582.1|WP_014179135.1|7917227_7918544_+|extracellular-solute-binding-protein	gnl|CDD|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.84002e-100
NC_016582.1|WP_014179141.1|7925636_7927964_+|molybdopterin-dependent-oxidoreductase	gnl|CDD|132240	TIGR03196, pucD, xanthine dehydrogenase D subunit. This gene has been characterized in B. subtilis as the molybdopterin binding-subunit of xanthine dehydrogenase (pucD), acting in conjunction with pucC, the FAD-binding subunit and pucE, the FeS-binding subunit. The more common XDH complex (GenProp0640) includes the xdhB gene which is related to pucD. It appears that most of the relatives of pucD outside of this narrow clade are involved in other processes as they are found in unrelated genomic contexts, contain the more common XDH complex and/or do not appear to process purines to allantoin.	4.95991e-180
NC_016582.1|WP_014179146.1|7932405_7933545_-|peptidoglycan-binding-protein	gnl|CDD|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	9.12542e-07
NC_016582.1|WP_014179143.1|7928743_7930417_+|HAMP-domain-containing-protein	gnl|CDD|182539	PRK10549, PRK10549, two-component system sensor histidine kinase BaeS.	2.08557e-72
NC_016582.1|WP_055414007.1|7931635_7932409_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	9.53888e-100
NC_016582.1|WP_078610618.1|7916096_7916390_+|DUF3039-domain-containing-protein	gnl|CDD|378609	pfam11238, DUF3039, Protein of unknown function (DUF3039). This family of proteins with unknown function appears to be restricted to Actinobacteria.	3.44164e-35
NC_016582.1|WP_014179131.1|7913773_7915126_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl|CDD|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NC_016582.1|WP_014179144.1|7930427_7931639_-|ABC-transporter-permease	gnl|CDD|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	9.04824e-30
NC_016582.1|WP_043491364.1|7919628_7920489_+|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.31941e-81
NC_016582.1|WP_043491358.1|7915365_7915971_+|YqgE/AlgH-family-protein	gnl|CDD|234694	PRK00228, PRK00228, YqgE/AlgH family protein.	3.72002e-68
NC_016582.1|WP_014179130.1|7913403_7913685_+|HU-family-DNA-binding-protein	gnl|CDD|259859	cd14435, SPO1_TF1_like, Bacteriophage SPO1-encoded TF1 binds and bends DNA. This group contains proteins related to bacillus phage SPO1-encoded transcription factor 1 (TF1), a type II DNA-binding protein related to the DNA sequence specific (IHF) and non-specific (HU) domains. Type II DNA-binding proteins bind and bend DNA as dimers. Like IHF, TF1 binds DNA specifically and bends DNA sharply. Bacteriophage SPO1-encoded TF1 recognizes SPO1 phage DNA containing 5-(hydroxymethyl)-2'-deoxyuridine as opposed to thymine, Related family members includes integration host factor (IHF) and HU, also called type II DNA-binding proteins (DNABII), which are small dimeric proteins that specifically bind the DNA minor groove, inducing large bends in the DNA and serving as architectural factors in a variety of cellular processes such as recombination, initiation of replication/transcription and gene regulation. IHF binds DNA in a sequence specific manner while HU displays little or no sequence preference. IHF homologs are usually heterodimers, while HU homologs are typically homodimers (except HU heterodimers from E. coli and other enterobacteria). HU is highly basic and contributes to chromosomal compaction and maintenance of negative supercoiling, thus often referred to as histone-like protein. IHF is an essential cofactor in phage lambda site-specific recombination, having an architectural role during assembly of specialized nucleoprotein structures (snups).	3.10528e-36
NC_016582.1|WP_014179136.1|7918558_7919581_+|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.46985e-72
NC_016582.1|WP_043491366.1|7920497_7922177_+|beta-N-acetylhexosaminidase	gnl|CDD|119333	cd06563, GH20_chitobiase-like, The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.	0
NC_016582.1|WP_014179149.1|7935075_7935918_-|DUF1963-domain-containing-protein	gnl|CDD|370378	pfam09234, DUF1963, Domain of unknown function (DUF1963). This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.	9.80449e-08

Protein sequences

>NC_016582.1|WP_014179139.1|7922452_7923352_+|FAD-binding-domain-containing-protein
MTTHAPQAAHTVTLPGTLDEAVAALAAMPAAVPVAGGTDLMAAVNSGLLRPAALVGLGRITEIRGWRYLDGHALLGAGLSHARMGRPDFAALIPALAAAARAAGPPQIRNAGTLGGNIVTAAPSGDALPVLAALEATVIIAGPEGARREIPVSHLLAGVEMLRPGELVGFVRVPILHAPQAFLKATGRTGPGRSTASCAVVLDPARRGVRCAVGAVAPMPLRPLEAERWVASLIDWDGDRGRLDPQVTAAFGEYVAAACIPDPAPPADGSEPVPLPPAAVHLRRTVAALARRALGRALA
>NC_016582.1|WP_043491366.1|7920497_7922177_+|beta-N-acetylhexosaminidase
MNATGLIPAPHRAYELLDGAHYLLDAETLLHAGPGTESTARWLRATVGAATGLPLPPGEDHDNGVLLRISPEIERELGPEGYRITADGHAIRIEGGGPAGVFWGAQTFRQLLGPDAFRRAPVVTREEWAVPCGVIEDAPRFGWRGLMLDVARHFMPKGDVLAYVDLLAAHKLNVLHLHLTDDQGWRIEIRRYPRLTEVGAWRERTKFGHRASPLWDERPHGGYYTQDDIREIVAYAAERHITVVPEIDIPGHSQAAIAAYPELGNADAVDTASLGVWTTWGVNPNVLSPADTTLRFYENVLEEVLELFPGGFVHLGGDECPKEQWRASPAAQARIRELGLADEDELQNWFLGHFGRWLAERGRRLIGWDEILEGSTASALGADLAEGAAVSSWRGYAGGIAAARAGHDVVMCPKQQVYFDSRQAAGDDEPVPIGYVRTLEDVFRFEPVPPELTGAEAERVLGAQANVWTEVTEDRRRVDYQTFPRLAAFAEAVWSTLPPPPERDFTGFQERMAAHYARLDALGVDYRPPGGPRPWQRRPAPKGMVGSLGRPIDGSPPIV
>NC_016582.1|WP_043491364.1|7919628_7920489_+|carbohydrate-ABC-transporter-permease
MPRPRRPARPWRLAAEAAAVVIALVVAFPLYWMVLSAFKPEGEVQSAHPRPWTLHPQLDAFRRVFVQQDFGRYFVNSLVVAGAVVVLSALIAFLAATAVVRFRFRFRTTLLIMFLIAQMVPVEALAIPMFFLMRDLGTAVPGVGLNTLGSLILPHLAFSLPFAIWMLRGFVKAVPETLEEAAMIDGASRARFLWQVLFPLVLPGLVATSVFSFISAWNDFLFPKSFIISATENSTLPMALLVFFKPEQNDWGGIMAGSTVMTLPVLVFFVLVQRRLVSGLAGAVKG
>NC_016582.1|WP_014179136.1|7918558_7919581_+|sugar-ABC-transporter-permease
MARDIAPAVAGAEQPPGRDARPARRRLRPAARGNRPPAGRGPRHHPGWTPWLYLAPALMVLAGLLVYPVYQLGLISFLRYTQAQVSGGRPTEFIGFDNYAALFRDDQFWQVLLSTVLFAAACVLSTLAVGCSLAVLLTKVRAVPRTMLLLAALGAWATPPVTGSTVWVFLFDSSFGPVNKVLTWLGLSGFEDYSWTYGKYSAFTLVLLEVVWCSFPFVMVTVYAGIRAVPPELLEAAALDGASTWRTWRSIMAPLLRPVLVIVTIQSIIWDFKVFGQIYVMTNGGGIAGQNLVLNVYAYQKAFASSEYGLGSAIGVVMLLILLAVTLVYLRLLRRQGEDL
>NC_016582.1|WP_014179135.1|7917227_7918544_+|extracellular-solute-binding-protein
MKRSSLSLRLAAPAAALVLAGLTATACAPSTSSNTESTKDSKSGTIRVWLFREVNNAPKEKVVKEAVAEFTKKHSDTRVDVTYIPIETRAEKMKAAFNDPKSAPDVVEFGNTDTAGYVNDGGLADITAEFGKWEDAKSVTASVKESVSVAGKVYGVPWYVGVRALYYRTDIFKELGLKPPATQGELATAAHRIRAEHPDMFGISVGAKNVYGMLPFVWSAGGDLAEKRGDTYTAAIDSAASRKGLKTYTDLIAKDSCPPEQCAELGGDAGVQTFAGGKAGMAIGGDFSRQAMEDGAVKGKYAVVPLPGPQKGVISPAFAGGNNLGVMRGTTHRTLAVDFVELLGGGAYQSKMFDAMGNMPALTDVQEKVADKAPFTKPFVETLKSGTKFVPVTSAWSKIDSEAVIPTMMQEIVSGRKSVDAATADAAKKMDAAFSSAG
>NC_016582.1|WP_014179134.1|7916654_7917071_+|hypothetical-protein
MSGRGESGAERAAYLVFGAREIDEPDEPDGEAAGRFRQFEKDWDAQLERCERLAVERGYRPAGSCVVSAAQPTLPRLLEWADEPDCEIVLIAGRGVLERMRSCWPDWNQLVVRLAAAGVRVEAVPYPEPACPADESPS
>NC_016582.1|WP_078610618.1|7916096_7916390_+|DUF3039-domain-containing-protein
MSTLEPERGAGTGTLVEPTPQVSHGDGDHERYAHYVQKDKIMESALSGSPVVALCGKVWVPGRDPKKYPVCPMCKEIFDGMGAGGDKDKGKDGSGKK
>NC_016582.1|WP_043491358.1|7915365_7915971_+|YqgE/AlgH-family-protein
MTEVSSLTGRLLVATPALADPNFDRAVVLLLDHDEEGSLGVVLNRPTPVGVGDILESWAALAGEPGVVFQGGPVSLDSALGVAVVPGEAGRASEAGRVSSRTEDGPLGWRRVHGAIGLVDLEAPPELLAAAVGSLRIFAGYAGWGPGQLEDELSEGAWYVVESEPGDVSSPAPERLWRAVLRRQRSELAMVATYPDDPSLN
>NC_016582.1|WP_014179131.1|7913773_7915126_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MTRSNDVLLVHGGTPLEGEIRVRGAKNLVPKAMVAALLGSGPSRLRNVPDIRDVRVVRGLLQLHGVTVRPGDEAGELVLDPTHVESANVADIDAHAGSSRIPILFCGPLLHRLGHAFIPGLGGCDIGGRPIDFHFDVLRQFGATIEKRADGQYLEAPHRLRGAKIRLPYPSVGSTEQVLLTAVLAEGVTELSNAAVEPEIEDLICVLQKMGAIISMDTDRTIRITGVDKLGGYNHRALPDRLEAASWASAALATEGSIYVRGASQREMMTFLNTYRKVGGAFDIDDAGIRFWHPGGKLNAIALETDVHPGFQTDWQQPLVVALTQASGLSIVHETVYESRLGFTSALNQMGAHIQLYRECLGGSACRFGQRNFLHSAVVSGPTKLQGADLVIPDLRGGFSYLIAALAAQGTSRVHGIDLINRGYENFMSKLGDLGAKVELPGGEGSSQAS
>NC_016582.1|WP_014179130.1|7913403_7913685_+|HU-family-DNA-binding-protein
MNRSELVAALSERAEVTRKDADAVLAALAEVTGEIVAKGDEKVTIPGFLTFERTHRAARTARNPQTGEPIEIPAGYSVKVSAGSKLKEAAKGK
>NC_016582.1|WP_014179141.1|7925636_7927964_+|molybdopterin-dependent-oxidoreductase
MTGIADGTGAATATPAAGVPLTPKEPPTIGLGMSLQPTDAAAKTSGTFPYAADLWAEGLLWAAVLRSPHPHARIVSIDTAPAAQMPGVRAVVTHADVPGDAAHGRRVADRPVFAKDLVRHHGEPIAAVAADHPDTARLAAAAIAVEYEVLEPVTDPEQAFGAEPLHPDGNLVRHIPLSFGDPDVVGEVIVEGLYRIGRQDPAPIGAEAGLAVPRPDGGVEIYTASTDPHADRDLAAACFGLEPERVKVVVTGVPGAMGEREDPGMQLPLGLLALRTGHPVKLAATREESFLGHAHRHPTLLRYRHHADAEGKLVKVEAQILLDAGAYADSSGDALAAAVSFACGPYVVPHAFIEGWAVRTNNPPSGHVRGEGAMQVCAAYEGQMDKLAAKLGLDPAEIRLRNAMATGDLLPTGQTVTCPAPVAELLRAVRDTPLPPLPKDDPEEEWLLPGGPEGAGDPGAVRRGVGYALGMVHMLGAEGADEVSTATVKVTGSVATVICAAVETGQGFTTLARQIVQEILGIEEVHVAPVDTDQPPAGPAARGRHTWVSGGAVERAAKMVRTQLLQPLAHKFGMSTELLTIADGKITSYDGVLSTTVDEALEGKELWATAQCRPHPTEPLDETGQGDAFVGLAFCAIRAVVDVDIEIGAVRVVDMTIAQDVGRVLNPRQLAARIEAGVAQGIGAALTENLRTSRGVIRHPDLTGYTLPTAVDVPDIRIVKLVEERDVVAPFGAKAVSAVPVVTTPAAVAAAVRSASGRPVNRLPIRPQAAAVNRA
>NC_016582.1|WP_014179142.1|7927994_7928747_+|response-regulator-transcription-factor
MSARILVAEDDEKQARLIRIYLEREGNAVQTVHDGRSAIDRARTTRPDLIVLDVMMPQVDGLDVCRILRTDSQVPILLLTARATEEDMLLGLDLGADDYMTKPYSPRELTARVRALLRRSRAITGEPTLIRAGALEIDTACFEVRLAGELIALTGKEFAILALLAAEPGRAFTRAQIIDRVFGFEQNVLERTVDAHVMNLRRKLEQRGPGAPRMVETVYGRGYRLADPGREPNAGPDREPYPERGPGPAR
>NC_016582.1|WP_014179143.1|7928743_7930417_+|HAMP-domain-containing-protein
MSFRLRALALVMLLVIAATAATAWLTLRQATREANETAAADRADINRVTGELRQYGLRHGTWDGVGPTVRELSADTGQRIRVTTATGSGAPLADSDVLMGRKPRRTGTGAPLLVDPRPELRLPDGLVPVTAFKRTITEIAKYRSGTAYAACLTRSGFEVTVGRDDHGVPTYSAGRKTGSGGTSASRGSCQRPKPTTARFARYDKAGRPCVSATDEGITPCLQRVFAEQISDVAPPPLQVRLGALDEPPSALAAAPAVTVAVAVAVAAILGALLLSRTVLRPVSALTAASHGLGEGDLARRVPVTGRDEIAELGRSFNRMAESLQASEERQRRLVGDVAHELRTPLANLRGYLEALRDGVVDPEPELLASLHEEVLLQQRIVDDLQDLALAEAGALTYHREDIDLGELLETCRTVHRAQAERAGVALTVETPGGEPLYAHADADRLRQAVGNLVSNAVRATGPGGTVRLSLARRGAGAVVQVGDTGHGIPAEHLPHVFDRFWRADAARGRATGGSGLGLSIARQIVTDHQGTIGVESAVGAGTTFTIELPTTAADATP
>NC_016582.1|WP_014179144.1|7930427_7931639_-|ABC-transporter-permease
MSRRQGGSRRLRAARLRPADFVRLGGTGLRTRPLRVLLSALGIAIGVAAMLAVVGISMSGRAEVDRRLDRLGTNLLRVSPSQAMGQSSQLPEESTAMIRRIGPVLQVAATGAVKDAKVYRNEHMPSGRTGSIEVLAADPRLLASVGGKVRTGRWLDSATAEYPGVVLGRQAARRLDVHTPGTRLWLGGTWFSLVGIVDPVPLAPEIDQAALVGWPAAQRYLGFDGHPSTVYVRTEEDRVTAVRDVLAATANPEHPNQVVVSRPSDALAAREAAESALTGLLLGLGGVALLVGGVGVGNTMVISVLERRPEIGLRRALGATSGQIRGQFVTESLLLCALGGAAGAVLGTGITAVYAGVRGWPTEVPVWATAAGVGVTLAIGALAGLYPAIRAGRLAPTQALAGS
>NC_016582.1|WP_055414007.1|7931635_7932409_-|ABC-transporter-ATP-binding-protein
MRPVVVFEGVTKTYPGGVAAVRDTNLLIRSGELVAVVGPSGSGKSSLLHLMGTLDRPSAGRVTVDGHDVARLSDRELSALRAQRIGFVFQQFHLALGVPVLDTVADGLLYAGVPVRERRRRASEALARVGLGHRSGHLPHQLSGGERQRAAVARAVIGEPALLLADEPTGNLDSASGAAVLELLRELHTAGTTVVVITHDRELAAALDRRVEIRDGRIVADSGAVTAGGAGAAGGAGAAAPATLSAAADAASSGRRP
>NC_016582.1|WP_014179146.1|7932405_7933545_-|peptidoglycan-binding-protein
MGVGRRSVLVAAGAVAVSAVAVVGALGLGGGDGSDSGGSDSGRGDRTVRVTRGTLVDETAVDGTLDHGPEVPFETRAEGTITWLPKAEKTVTRGQTLLRVDEKPVVLLYGDLPMYRELAAGRDPDRPLRGLDVKQFESNLAMLGYSGFTVNDTYSQLTADAVKRWQRDLGRPRTGKVGTGDIAYVSGPIRIARTSVRVGAQATGNVLSYTSTARSVTVDAPAGETGWAERGNRVTVELPDGHTVKGRVAEVGQDASPAQGAEGGGGGGDGGSDGDAAKNAKVPVLIRIKDQEALGQLSSTPVTVRYVGRKRENVLTVPVAALVALAEGGHGLELADDGGADGDGKGNRFVAVKTGLFANGKVEVSGSAVREGLKVRIPE
>NC_016582.1|WP_014179147.1|7933544_7934153_-|hypothetical-protein
MKACARRRFAARVWPAVVVSVMALGLAGCGGGGGGGDEVASAGDGKTKSGSSRAGDGEIARYVEGQRRFVKCLREEGLDVPDPDAKGHIDFGDARELKADPKFTRAQVKCEKFSLPVPEELERQERPKLSAKEIATRKRYAKCMQENGVPEAPDVGDDGYSDEDFQNDGKMAWDPTSARAKRAIRICAPIIGDPVNPGKAKG
>NC_016582.1|WP_014179148.1|7934309_7934933_-|hypothetical-protein
MLADEYGYQVSRGTAATYPGVYERLRREKNIARNFLLFAVVMVAVAVAGVQWLVPVSLDAGVVVAGGAGTLALFSGLGGAIGLAVTGSKLALARSHPFQAWPCQLEETKDHQRLILLLAPDGSVARELDSAVPDTVWHGTPDGRGMLWIAGDLRSQCLVATPEAKELWRAKGRPYGASPVAGGGRLRAVEDELLRTATQEAFSAWLQ
>NC_016582.1|WP_014179149.1|7935075_7935918_-|DUF1963-domain-containing-protein
MDPESRLSALRDFCAERLGPQLAARYVDLARPGFALTAAENPGEAAGHSRFGGRAMLEPGTPWPTCDGFPLSLIAVLDADTLSPWLGDVLPAGTGLLNFFCLDAESEQHDPVSYDLMNKYGHYEVEVSSVIPARFAHAVETDPPARSSVFEPIPWAAKPGFAFPDTWDPAWNGFDVGPDADDMARAMPGNYVENQLTEWSERPGALDSEDMAFGRPQFPTGSSPMVPFGKDPNRYHHLLQLASYEEWSIGGDGGWMHWAIPTDALRIGDFGQAVPTPDIW
>NC_016582.1|WP_106436685.1|7936037_7936631_+|RNA-polymerase-sigma-factor
MREEHTDDTDGELLRRSQRDPTAFEPLVARHSAALHGYLVRRAPGAADDLLSELWLRAYASRHGFDAARGTARAWLFGVARNVLAAHWRRLETEASPGSARFAEGIAGDPWHAVDQRLDAAAVAPVLRHALTKLPAVERELMLLIAWEQLTPTEAASVIGVPPGTARSRLHRARTRLRERLGAFVSSAQMSKTGESA

Crispr_ID: NC_016582_15

• CRISPR_ID: NC_016582_15
• CRISPR_location: 7924510-7924619
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_15

Consensus_repeat	Method
GGCGGGTTCGTGGACGACGGCTACGACG	CRISPRCasFinder

spacers of NC_016582_15

>15.1|7924538|53|NC_016582|CRISPRCasFinder
GCCACGCGGGGGCGGGGACGCCGCCGCACGGTGTCGCGCCGGGTGGCGGTCGC

CRISPR arrays and Neighbor proteins around NC_016582_15

CRISPR arrays

The CRISPR arrays of NC_016582_15

>merge|NC_016582|15|7924510-7924619|CRISPRCasFinder
GGCGGGTTCGTGGACGACGGCTACGACGGCCACGCGGGGGCGGGGACGCCGCCGCACGGTGTCGCGCCGGGTGGCGGTCGCGGCGGGTTCGTGGACGGCGGCTACGACGC

>NC_016582|15|14|7924510-7924619|CRISPRCasFinder
GGCGGGTTCGTGGACGACGGCTACGACG	GCCACGCGGGGGCGGGGACGCCGCCGCACGGTGTCGCGCCGGGTGGCGGTCGC
GGCGGGTTCGTGGACGGCGGCTACGACGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_106436685.1|7936037_7936631_+|RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|224511
NC_016582.1|WP_014179148.1|7934309_7934933_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014179139.1|7922452_7923352_+|FAD-binding-domain-containing-protein	unknown	unknown	gnl|CDD|366378
NC_016582.1|WP_014179147.1|7933544_7934153_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014179134.1|7916654_7917071_+|hypothetical-protein	unknown	unknown	gnl|CDD|238206
NC_016582.1|WP_014179142.1|7927994_7928747_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NC_016582.1|WP_014179135.1|7917227_7918544_+|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270450
NC_016582.1|WP_014179141.1|7925636_7927964_+|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|132240
NC_016582.1|WP_014179146.1|7932405_7933545_-|peptidoglycan-binding-protein	unknown	unknown	gnl|CDD|366659
NC_016582.1|WP_014179143.1|7928743_7930417_+|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|182539
NC_016582.1|WP_055414007.1|7931635_7932409_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213222
NC_016582.1|WP_078610618.1|7916096_7916390_+|DUF3039-domain-containing-protein	unknown	unknown	gnl|CDD|378609
NC_016582.1|WP_014179131.1|7913773_7915126_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl|CDD|236486
NC_016582.1|WP_014179144.1|7930427_7931639_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|223650
NC_016582.1|WP_043491364.1|7919628_7920489_+|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NC_016582.1|WP_043491358.1|7915365_7915971_+|YqgE/AlgH-family-protein	unknown	unknown	gnl|CDD|234694
NC_016582.1|WP_014179130.1|7913403_7913685_+|HU-family-DNA-binding-protein	unknown	unknown	gnl|CDD|259859
NC_016582.1|WP_014179136.1|7918558_7919581_+|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NC_016582.1|WP_043491366.1|7920497_7922177_+|beta-N-acetylhexosaminidase	unknown	unknown	gnl|CDD|119333
NC_016582.1|WP_014179149.1|7935075_7935918_-|DUF1963-domain-containing-protein	unknown	unknown	gnl|CDD|370378

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_106436685.1|7936037_7936631_+|RNA-polymerase-sigma-factor	gnl|CDD|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	4.93901e-27
NC_016582.1|WP_014179139.1|7922452_7923352_+|FAD-binding-domain-containing-protein	gnl|CDD|366378	pfam00941, FAD_binding_5, FAD binding domain in molybdopterin dehydrogenase.	4.68028e-46
NC_016582.1|WP_014179134.1|7916654_7917071_+|hypothetical-protein	gnl|CDD|238206	cd00338, Ser_Recombinase, Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.	0.00480555
NC_016582.1|WP_014179142.1|7927994_7928747_+|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.108e-78
NC_016582.1|WP_014179135.1|7917227_7918544_+|extracellular-solute-binding-protein	gnl|CDD|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.84002e-100
NC_016582.1|WP_014179141.1|7925636_7927964_+|molybdopterin-dependent-oxidoreductase	gnl|CDD|132240	TIGR03196, pucD, xanthine dehydrogenase D subunit. This gene has been characterized in B. subtilis as the molybdopterin binding-subunit of xanthine dehydrogenase (pucD), acting in conjunction with pucC, the FAD-binding subunit and pucE, the FeS-binding subunit. The more common XDH complex (GenProp0640) includes the xdhB gene which is related to pucD. It appears that most of the relatives of pucD outside of this narrow clade are involved in other processes as they are found in unrelated genomic contexts, contain the more common XDH complex and/or do not appear to process purines to allantoin.	4.95991e-180
NC_016582.1|WP_014179146.1|7932405_7933545_-|peptidoglycan-binding-protein	gnl|CDD|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	9.12542e-07
NC_016582.1|WP_014179143.1|7928743_7930417_+|HAMP-domain-containing-protein	gnl|CDD|182539	PRK10549, PRK10549, two-component system sensor histidine kinase BaeS.	2.08557e-72
NC_016582.1|WP_055414007.1|7931635_7932409_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	9.53888e-100
NC_016582.1|WP_078610618.1|7916096_7916390_+|DUF3039-domain-containing-protein	gnl|CDD|378609	pfam11238, DUF3039, Protein of unknown function (DUF3039). This family of proteins with unknown function appears to be restricted to Actinobacteria.	3.44164e-35
NC_016582.1|WP_014179131.1|7913773_7915126_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl|CDD|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NC_016582.1|WP_014179144.1|7930427_7931639_-|ABC-transporter-permease	gnl|CDD|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	9.04824e-30
NC_016582.1|WP_043491364.1|7919628_7920489_+|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.31941e-81
NC_016582.1|WP_043491358.1|7915365_7915971_+|YqgE/AlgH-family-protein	gnl|CDD|234694	PRK00228, PRK00228, YqgE/AlgH family protein.	3.72002e-68
NC_016582.1|WP_014179130.1|7913403_7913685_+|HU-family-DNA-binding-protein	gnl|CDD|259859	cd14435, SPO1_TF1_like, Bacteriophage SPO1-encoded TF1 binds and bends DNA. This group contains proteins related to bacillus phage SPO1-encoded transcription factor 1 (TF1), a type II DNA-binding protein related to the DNA sequence specific (IHF) and non-specific (HU) domains. Type II DNA-binding proteins bind and bend DNA as dimers. Like IHF, TF1 binds DNA specifically and bends DNA sharply. Bacteriophage SPO1-encoded TF1 recognizes SPO1 phage DNA containing 5-(hydroxymethyl)-2'-deoxyuridine as opposed to thymine, Related family members includes integration host factor (IHF) and HU, also called type II DNA-binding proteins (DNABII), which are small dimeric proteins that specifically bind the DNA minor groove, inducing large bends in the DNA and serving as architectural factors in a variety of cellular processes such as recombination, initiation of replication/transcription and gene regulation. IHF binds DNA in a sequence specific manner while HU displays little or no sequence preference. IHF homologs are usually heterodimers, while HU homologs are typically homodimers (except HU heterodimers from E. coli and other enterobacteria). HU is highly basic and contributes to chromosomal compaction and maintenance of negative supercoiling, thus often referred to as histone-like protein. IHF is an essential cofactor in phage lambda site-specific recombination, having an architectural role during assembly of specialized nucleoprotein structures (snups).	3.10528e-36
NC_016582.1|WP_014179136.1|7918558_7919581_+|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.46985e-72
NC_016582.1|WP_043491366.1|7920497_7922177_+|beta-N-acetylhexosaminidase	gnl|CDD|119333	cd06563, GH20_chitobiase-like, The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.	0
NC_016582.1|WP_014179149.1|7935075_7935918_-|DUF1963-domain-containing-protein	gnl|CDD|370378	pfam09234, DUF1963, Domain of unknown function (DUF1963). This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.	9.80449e-08

Protein sequences

>NC_016582.1|WP_014179139.1|7922452_7923352_+|FAD-binding-domain-containing-protein
MTTHAPQAAHTVTLPGTLDEAVAALAAMPAAVPVAGGTDLMAAVNSGLLRPAALVGLGRITEIRGWRYLDGHALLGAGLSHARMGRPDFAALIPALAAAARAAGPPQIRNAGTLGGNIVTAAPSGDALPVLAALEATVIIAGPEGARREIPVSHLLAGVEMLRPGELVGFVRVPILHAPQAFLKATGRTGPGRSTASCAVVLDPARRGVRCAVGAVAPMPLRPLEAERWVASLIDWDGDRGRLDPQVTAAFGEYVAAACIPDPAPPADGSEPVPLPPAAVHLRRTVAALARRALGRALA
>NC_016582.1|WP_043491366.1|7920497_7922177_+|beta-N-acetylhexosaminidase
MNATGLIPAPHRAYELLDGAHYLLDAETLLHAGPGTESTARWLRATVGAATGLPLPPGEDHDNGVLLRISPEIERELGPEGYRITADGHAIRIEGGGPAGVFWGAQTFRQLLGPDAFRRAPVVTREEWAVPCGVIEDAPRFGWRGLMLDVARHFMPKGDVLAYVDLLAAHKLNVLHLHLTDDQGWRIEIRRYPRLTEVGAWRERTKFGHRASPLWDERPHGGYYTQDDIREIVAYAAERHITVVPEIDIPGHSQAAIAAYPELGNADAVDTASLGVWTTWGVNPNVLSPADTTLRFYENVLEEVLELFPGGFVHLGGDECPKEQWRASPAAQARIRELGLADEDELQNWFLGHFGRWLAERGRRLIGWDEILEGSTASALGADLAEGAAVSSWRGYAGGIAAARAGHDVVMCPKQQVYFDSRQAAGDDEPVPIGYVRTLEDVFRFEPVPPELTGAEAERVLGAQANVWTEVTEDRRRVDYQTFPRLAAFAEAVWSTLPPPPERDFTGFQERMAAHYARLDALGVDYRPPGGPRPWQRRPAPKGMVGSLGRPIDGSPPIV
>NC_016582.1|WP_043491364.1|7919628_7920489_+|carbohydrate-ABC-transporter-permease
MPRPRRPARPWRLAAEAAAVVIALVVAFPLYWMVLSAFKPEGEVQSAHPRPWTLHPQLDAFRRVFVQQDFGRYFVNSLVVAGAVVVLSALIAFLAATAVVRFRFRFRTTLLIMFLIAQMVPVEALAIPMFFLMRDLGTAVPGVGLNTLGSLILPHLAFSLPFAIWMLRGFVKAVPETLEEAAMIDGASRARFLWQVLFPLVLPGLVATSVFSFISAWNDFLFPKSFIISATENSTLPMALLVFFKPEQNDWGGIMAGSTVMTLPVLVFFVLVQRRLVSGLAGAVKG
>NC_016582.1|WP_014179136.1|7918558_7919581_+|sugar-ABC-transporter-permease
MARDIAPAVAGAEQPPGRDARPARRRLRPAARGNRPPAGRGPRHHPGWTPWLYLAPALMVLAGLLVYPVYQLGLISFLRYTQAQVSGGRPTEFIGFDNYAALFRDDQFWQVLLSTVLFAAACVLSTLAVGCSLAVLLTKVRAVPRTMLLLAALGAWATPPVTGSTVWVFLFDSSFGPVNKVLTWLGLSGFEDYSWTYGKYSAFTLVLLEVVWCSFPFVMVTVYAGIRAVPPELLEAAALDGASTWRTWRSIMAPLLRPVLVIVTIQSIIWDFKVFGQIYVMTNGGGIAGQNLVLNVYAYQKAFASSEYGLGSAIGVVMLLILLAVTLVYLRLLRRQGEDL
>NC_016582.1|WP_014179135.1|7917227_7918544_+|extracellular-solute-binding-protein
MKRSSLSLRLAAPAAALVLAGLTATACAPSTSSNTESTKDSKSGTIRVWLFREVNNAPKEKVVKEAVAEFTKKHSDTRVDVTYIPIETRAEKMKAAFNDPKSAPDVVEFGNTDTAGYVNDGGLADITAEFGKWEDAKSVTASVKESVSVAGKVYGVPWYVGVRALYYRTDIFKELGLKPPATQGELATAAHRIRAEHPDMFGISVGAKNVYGMLPFVWSAGGDLAEKRGDTYTAAIDSAASRKGLKTYTDLIAKDSCPPEQCAELGGDAGVQTFAGGKAGMAIGGDFSRQAMEDGAVKGKYAVVPLPGPQKGVISPAFAGGNNLGVMRGTTHRTLAVDFVELLGGGAYQSKMFDAMGNMPALTDVQEKVADKAPFTKPFVETLKSGTKFVPVTSAWSKIDSEAVIPTMMQEIVSGRKSVDAATADAAKKMDAAFSSAG
>NC_016582.1|WP_014179134.1|7916654_7917071_+|hypothetical-protein
MSGRGESGAERAAYLVFGAREIDEPDEPDGEAAGRFRQFEKDWDAQLERCERLAVERGYRPAGSCVVSAAQPTLPRLLEWADEPDCEIVLIAGRGVLERMRSCWPDWNQLVVRLAAAGVRVEAVPYPEPACPADESPS
>NC_016582.1|WP_078610618.1|7916096_7916390_+|DUF3039-domain-containing-protein
MSTLEPERGAGTGTLVEPTPQVSHGDGDHERYAHYVQKDKIMESALSGSPVVALCGKVWVPGRDPKKYPVCPMCKEIFDGMGAGGDKDKGKDGSGKK
>NC_016582.1|WP_043491358.1|7915365_7915971_+|YqgE/AlgH-family-protein
MTEVSSLTGRLLVATPALADPNFDRAVVLLLDHDEEGSLGVVLNRPTPVGVGDILESWAALAGEPGVVFQGGPVSLDSALGVAVVPGEAGRASEAGRVSSRTEDGPLGWRRVHGAIGLVDLEAPPELLAAAVGSLRIFAGYAGWGPGQLEDELSEGAWYVVESEPGDVSSPAPERLWRAVLRRQRSELAMVATYPDDPSLN
>NC_016582.1|WP_014179131.1|7913773_7915126_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MTRSNDVLLVHGGTPLEGEIRVRGAKNLVPKAMVAALLGSGPSRLRNVPDIRDVRVVRGLLQLHGVTVRPGDEAGELVLDPTHVESANVADIDAHAGSSRIPILFCGPLLHRLGHAFIPGLGGCDIGGRPIDFHFDVLRQFGATIEKRADGQYLEAPHRLRGAKIRLPYPSVGSTEQVLLTAVLAEGVTELSNAAVEPEIEDLICVLQKMGAIISMDTDRTIRITGVDKLGGYNHRALPDRLEAASWASAALATEGSIYVRGASQREMMTFLNTYRKVGGAFDIDDAGIRFWHPGGKLNAIALETDVHPGFQTDWQQPLVVALTQASGLSIVHETVYESRLGFTSALNQMGAHIQLYRECLGGSACRFGQRNFLHSAVVSGPTKLQGADLVIPDLRGGFSYLIAALAAQGTSRVHGIDLINRGYENFMSKLGDLGAKVELPGGEGSSQAS
>NC_016582.1|WP_014179130.1|7913403_7913685_+|HU-family-DNA-binding-protein
MNRSELVAALSERAEVTRKDADAVLAALAEVTGEIVAKGDEKVTIPGFLTFERTHRAARTARNPQTGEPIEIPAGYSVKVSAGSKLKEAAKGK
>NC_016582.1|WP_014179141.1|7925636_7927964_+|molybdopterin-dependent-oxidoreductase
MTGIADGTGAATATPAAGVPLTPKEPPTIGLGMSLQPTDAAAKTSGTFPYAADLWAEGLLWAAVLRSPHPHARIVSIDTAPAAQMPGVRAVVTHADVPGDAAHGRRVADRPVFAKDLVRHHGEPIAAVAADHPDTARLAAAAIAVEYEVLEPVTDPEQAFGAEPLHPDGNLVRHIPLSFGDPDVVGEVIVEGLYRIGRQDPAPIGAEAGLAVPRPDGGVEIYTASTDPHADRDLAAACFGLEPERVKVVVTGVPGAMGEREDPGMQLPLGLLALRTGHPVKLAATREESFLGHAHRHPTLLRYRHHADAEGKLVKVEAQILLDAGAYADSSGDALAAAVSFACGPYVVPHAFIEGWAVRTNNPPSGHVRGEGAMQVCAAYEGQMDKLAAKLGLDPAEIRLRNAMATGDLLPTGQTVTCPAPVAELLRAVRDTPLPPLPKDDPEEEWLLPGGPEGAGDPGAVRRGVGYALGMVHMLGAEGADEVSTATVKVTGSVATVICAAVETGQGFTTLARQIVQEILGIEEVHVAPVDTDQPPAGPAARGRHTWVSGGAVERAAKMVRTQLLQPLAHKFGMSTELLTIADGKITSYDGVLSTTVDEALEGKELWATAQCRPHPTEPLDETGQGDAFVGLAFCAIRAVVDVDIEIGAVRVVDMTIAQDVGRVLNPRQLAARIEAGVAQGIGAALTENLRTSRGVIRHPDLTGYTLPTAVDVPDIRIVKLVEERDVVAPFGAKAVSAVPVVTTPAAVAAAVRSASGRPVNRLPIRPQAAAVNRA
>NC_016582.1|WP_014179142.1|7927994_7928747_+|response-regulator-transcription-factor
MSARILVAEDDEKQARLIRIYLEREGNAVQTVHDGRSAIDRARTTRPDLIVLDVMMPQVDGLDVCRILRTDSQVPILLLTARATEEDMLLGLDLGADDYMTKPYSPRELTARVRALLRRSRAITGEPTLIRAGALEIDTACFEVRLAGELIALTGKEFAILALLAAEPGRAFTRAQIIDRVFGFEQNVLERTVDAHVMNLRRKLEQRGPGAPRMVETVYGRGYRLADPGREPNAGPDREPYPERGPGPAR
>NC_016582.1|WP_014179143.1|7928743_7930417_+|HAMP-domain-containing-protein
MSFRLRALALVMLLVIAATAATAWLTLRQATREANETAAADRADINRVTGELRQYGLRHGTWDGVGPTVRELSADTGQRIRVTTATGSGAPLADSDVLMGRKPRRTGTGAPLLVDPRPELRLPDGLVPVTAFKRTITEIAKYRSGTAYAACLTRSGFEVTVGRDDHGVPTYSAGRKTGSGGTSASRGSCQRPKPTTARFARYDKAGRPCVSATDEGITPCLQRVFAEQISDVAPPPLQVRLGALDEPPSALAAAPAVTVAVAVAVAAILGALLLSRTVLRPVSALTAASHGLGEGDLARRVPVTGRDEIAELGRSFNRMAESLQASEERQRRLVGDVAHELRTPLANLRGYLEALRDGVVDPEPELLASLHEEVLLQQRIVDDLQDLALAEAGALTYHREDIDLGELLETCRTVHRAQAERAGVALTVETPGGEPLYAHADADRLRQAVGNLVSNAVRATGPGGTVRLSLARRGAGAVVQVGDTGHGIPAEHLPHVFDRFWRADAARGRATGGSGLGLSIARQIVTDHQGTIGVESAVGAGTTFTIELPTTAADATP
>NC_016582.1|WP_014179144.1|7930427_7931639_-|ABC-transporter-permease
MSRRQGGSRRLRAARLRPADFVRLGGTGLRTRPLRVLLSALGIAIGVAAMLAVVGISMSGRAEVDRRLDRLGTNLLRVSPSQAMGQSSQLPEESTAMIRRIGPVLQVAATGAVKDAKVYRNEHMPSGRTGSIEVLAADPRLLASVGGKVRTGRWLDSATAEYPGVVLGRQAARRLDVHTPGTRLWLGGTWFSLVGIVDPVPLAPEIDQAALVGWPAAQRYLGFDGHPSTVYVRTEEDRVTAVRDVLAATANPEHPNQVVVSRPSDALAAREAAESALTGLLLGLGGVALLVGGVGVGNTMVISVLERRPEIGLRRALGATSGQIRGQFVTESLLLCALGGAAGAVLGTGITAVYAGVRGWPTEVPVWATAAGVGVTLAIGALAGLYPAIRAGRLAPTQALAGS
>NC_016582.1|WP_055414007.1|7931635_7932409_-|ABC-transporter-ATP-binding-protein
MRPVVVFEGVTKTYPGGVAAVRDTNLLIRSGELVAVVGPSGSGKSSLLHLMGTLDRPSAGRVTVDGHDVARLSDRELSALRAQRIGFVFQQFHLALGVPVLDTVADGLLYAGVPVRERRRRASEALARVGLGHRSGHLPHQLSGGERQRAAVARAVIGEPALLLADEPTGNLDSASGAAVLELLRELHTAGTTVVVITHDRELAAALDRRVEIRDGRIVADSGAVTAGGAGAAGGAGAAAPATLSAAADAASSGRRP
>NC_016582.1|WP_014179146.1|7932405_7933545_-|peptidoglycan-binding-protein
MGVGRRSVLVAAGAVAVSAVAVVGALGLGGGDGSDSGGSDSGRGDRTVRVTRGTLVDETAVDGTLDHGPEVPFETRAEGTITWLPKAEKTVTRGQTLLRVDEKPVVLLYGDLPMYRELAAGRDPDRPLRGLDVKQFESNLAMLGYSGFTVNDTYSQLTADAVKRWQRDLGRPRTGKVGTGDIAYVSGPIRIARTSVRVGAQATGNVLSYTSTARSVTVDAPAGETGWAERGNRVTVELPDGHTVKGRVAEVGQDASPAQGAEGGGGGGDGGSDGDAAKNAKVPVLIRIKDQEALGQLSSTPVTVRYVGRKRENVLTVPVAALVALAEGGHGLELADDGGADGDGKGNRFVAVKTGLFANGKVEVSGSAVREGLKVRIPE
>NC_016582.1|WP_014179147.1|7933544_7934153_-|hypothetical-protein
MKACARRRFAARVWPAVVVSVMALGLAGCGGGGGGGDEVASAGDGKTKSGSSRAGDGEIARYVEGQRRFVKCLREEGLDVPDPDAKGHIDFGDARELKADPKFTRAQVKCEKFSLPVPEELERQERPKLSAKEIATRKRYAKCMQENGVPEAPDVGDDGYSDEDFQNDGKMAWDPTSARAKRAIRICAPIIGDPVNPGKAKG
>NC_016582.1|WP_014179148.1|7934309_7934933_-|hypothetical-protein
MLADEYGYQVSRGTAATYPGVYERLRREKNIARNFLLFAVVMVAVAVAGVQWLVPVSLDAGVVVAGGAGTLALFSGLGGAIGLAVTGSKLALARSHPFQAWPCQLEETKDHQRLILLLAPDGSVARELDSAVPDTVWHGTPDGRGMLWIAGDLRSQCLVATPEAKELWRAKGRPYGASPVAGGGRLRAVEDELLRTATQEAFSAWLQ
>NC_016582.1|WP_014179149.1|7935075_7935918_-|DUF1963-domain-containing-protein
MDPESRLSALRDFCAERLGPQLAARYVDLARPGFALTAAENPGEAAGHSRFGGRAMLEPGTPWPTCDGFPLSLIAVLDADTLSPWLGDVLPAGTGLLNFFCLDAESEQHDPVSYDLMNKYGHYEVEVSSVIPARFAHAVETDPPARSSVFEPIPWAAKPGFAFPDTWDPAWNGFDVGPDADDMARAMPGNYVENQLTEWSERPGALDSEDMAFGRPQFPTGSSPMVPFGKDPNRYHHLLQLASYEEWSIGGDGGWMHWAIPTDALRIGDFGQAVPTPDIW
>NC_016582.1|WP_106436685.1|7936037_7936631_+|RNA-polymerase-sigma-factor
MREEHTDDTDGELLRRSQRDPTAFEPLVARHSAALHGYLVRRAPGAADDLLSELWLRAYASRHGFDAARGTARAWLFGVARNVLAAHWRRLETEASPGSARFAEGIAGDPWHAVDQRLDAAAVAPVLRHALTKLPAVERELMLLIAWEQLTPTEAASVIGVPPGTARSRLHRARTRLRERLGAFVSSAQMSKTGESA

Crispr_ID: NC_016582_17

• CRISPR_ID: NC_016582_17
• CRISPR_location: 8774954-8775061
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_17

Consensus_repeat	Method
GGTTACTGGTTCGAGTCCAGTCGGGGGAGC	CRISPRCasFinder

spacers of NC_016582_17

>17.1|8774984|48|NC_016582|CRISPRCasFinder
TCGGTCCCCTGTAGCTCAATTGGCAGAGCATTCGGCTGTTAACCGGAG

CRISPR arrays and Neighbor proteins around NC_016582_17

CRISPR arrays

The CRISPR arrays of NC_016582_17

>merge|NC_016582|17|8774954-8775061|CRISPRCasFinder
GGTTACTGGTTCGAGTCCAGTCGGGGGAGCTCGGTCCCCTGTAGCTCAATTGGCAGAGCATTCGGCTGTTAACCGGAGGGTTACTGGTTCGAGTCCAGTCGGGGGAGC

>NC_016582|17|16|8774954-8775061|CRISPRCasFinder
GGTTACTGGTTCGAGTCCAGTCGGGGGAGC	TCGGTCCCCTGTAGCTCAATTGGCAGAGCATTCGGCTGTTAACCGGAG
GGTTACTGGTTCGAGTCCAGTCGGGGGAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014179926.1|8767951_8769232_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|170080
NC_016582.1|WP_078610653.1|8766227_8767670_+|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl|CDD|235098
NC_016582.1|WP_043487670.1|8772911_8774402_-|sugar-kinase	unknown	unknown	gnl|CDD|198375
NC_016582.1|WP_043491704.1|8763021_8765124_-|molybdopterin-oxidoreductase-family-protein	unknown	unknown	gnl|CDD|239155
NC_016582.1|WP_014179942.1|8788481_8789804_+|MFS-transporter	unknown	unknown	gnl|CDD|340929
NC_016582.1|WP_014179930.1|8774429_8774699_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014179936.1|8781307_8781631_+|hypothetical-protein	unknown	unknown	gnl|CDD|225355
NC_016582.1|WP_014179937.1|8781731_8782322_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379883
NC_016582.1|WP_014179941.1|8787229_8788264_-|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NC_016582.1|WP_014179938.1|8782592_8784893_+|MMPL-family-transporter	unknown	unknown	gnl|CDD|225272
NC_016582.1|WP_055414304.1|8762565_8763000_+|VOC-family-protein	unknown	unknown	gnl|CDD|319906
NC_016582.1|WP_014179940.1|8786102_8787137_-|amidohydrolase	unknown	unknown	gnl|CDD|368185
NC_016582.1|WP_055414027.1|8765304_8766231_+|sirohydrochlorin-chelatase	unknown	unknown	gnl|CDD|225049
NC_016582.1|WP_143675873.1|8790334_8790961_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014179927.1|8769319_8771311_+|DNA-primase	unknown	unknown	gnl|CDD|235551
NC_016582.1|WP_043487669.1|8771428_8772856_+|RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|235640
NC_016582.1|WP_014179920.1|8761318_8762317_+|adenosine-deaminase	unknown	unknown	gnl|CDD|236480
NC_016582.1|WP_014179932.1|8777342_8778542_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224172
NC_016582.1|WP_014179931.1|8776344_8777307_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|132002
NC_016582.1|WP_014179939.1|8785025_8785814_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014179926.1|8767951_8769232_+|FAD-dependent-oxidoreductase	gnl|CDD|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	4.29686e-75
NC_016582.1|WP_078610653.1|8766227_8767670_+|deoxyguanosinetriphosphate-triphosphohydrolase	gnl|CDD|235098	PRK03007, PRK03007, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0
NC_016582.1|WP_043487670.1|8772911_8774402_-|sugar-kinase	gnl|CDD|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	1.42341e-111
NC_016582.1|WP_043491704.1|8763021_8765124_-|molybdopterin-oxidoreductase-family-protein	gnl|CDD|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NC_016582.1|WP_014179942.1|8788481_8789804_+|MFS-transporter	gnl|CDD|340929	cd17371, MFS_MucK, Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.10387e-39
NC_016582.1|WP_014179936.1|8781307_8781631_+|hypothetical-protein	gnl|CDD|225355	COG2761, FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism].	7.22105e-09
NC_016582.1|WP_014179937.1|8781731_8782322_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	1.18811e-12
NC_016582.1|WP_014179941.1|8787229_8788264_-|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.2267e-96
NC_016582.1|WP_014179938.1|8782592_8784893_+|MMPL-family-transporter	gnl|CDD|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.05265e-107
NC_016582.1|WP_055414304.1|8762565_8763000_+|VOC-family-protein	gnl|CDD|319906	cd07242, VOC_BsYqjT, vicinal oxygen chelate (VOC) family protein similar to Bacillus subtilis YqjT. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	6.05025e-38
NC_016582.1|WP_014179940.1|8786102_8787137_-|amidohydrolase	gnl|CDD|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	1.27179e-33
NC_016582.1|WP_055414027.1|8765304_8766231_+|sirohydrochlorin-chelatase	gnl|CDD|225049	COG2138, COG2138, Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism].	1.03238e-28
NC_016582.1|WP_014179927.1|8769319_8771311_+|DNA-primase	gnl|CDD|235551	PRK05667, dnaG, DNA primase; Validated.	0
NC_016582.1|WP_043487669.1|8771428_8772856_+|RNA-polymerase-sigma-factor	gnl|CDD|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	2.54556e-164
NC_016582.1|WP_014179920.1|8761318_8762317_+|adenosine-deaminase	gnl|CDD|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	2.60784e-150
NC_016582.1|WP_014179932.1|8777342_8778542_-|FAD-dependent-oxidoreductase	gnl|CDD|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	4.31858e-63
NC_016582.1|WP_014179931.1|8776344_8777307_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	7.3614e-86
NC_016582.1|WP_014179939.1|8785025_8785814_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.18372e-55

Protein sequences

>NC_016582.1|WP_014179930.1|8774429_8774699_-|hypothetical-protein
MRYRLTFITGLAVGYVLGTRAGRERYEQLRTCAQQFVRNPAVRNTAETAALGGRQAAARAFEKTKPLRERIGQREKSAGGEDDWGTSNT
>NC_016582.1|WP_043487670.1|8772911_8774402_-|sugar-kinase
MGIVAGLDSSSESTRIVVCDTDTGAVIRQGYAPHPAADAATPPGAAPASPYDVDPQSWLLSLGEAAGGKLLEGVQAIGVSAQGHGLLTLDAGGALVRPALVGNDKRAQSAAADLIDSLGGRAAWAQAVGAVPSATQAVAKLRWLARTEPDAARRVTELMQPHDWLVWQLLGRPARRTTDRGTASDTGYWSAATGSWRPDLIELALGHQVRLPEVIGPAEAAGHTPEGLLISAGTGETMAAAFGLGVGIGDAVISLGASGSVFSVHHEALVDPSGTITSYADATGMHLPVVHTLNAVRALRGTAELLSVDLEELSALALKSTPGSYGLVLLPYLEGERTPHLPHTAGTLTGLRRESMKPEHLARAAFEGMLCGLADALDVLRGRGVAVRRVFLLGPAADLPAVRAIAPALLGAQVVVPQPADYAALGAARQAAWALGAAHGTLSPHQPPLWPAAASQVFEAGEELAVGQAVRQQYVAVREQTHPGAFEAGPGVGQLG
>NC_016582.1|WP_043487669.1|8771428_8772856_+|RNA-polymerase-sigma-factor
MPESSERGGVGQEGPDSPADPLMMYGTDGGVAAAAVPDRSAASAAITLEVAPVQTQTLTDAAPLATPPQSPHPHAGSRPTAASAPAALEAVEAVEAVEALAAVTAGPEAEPPEAAEAAEAAGPPEAAEAEEAADPSEAPEAAEAPDAPEAPDAAEEAPEEAPEPPVRAETSSGPSSDLFRQYLREIGRIPLLSAAEEVELARRVEAGLFAEEKLSNTPDLDTQLAHDFDQLVVLGRMAKRRLIEANLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRMLQERGYEPTPEEVAHHLDLLPERVSEVLRLAQEPVSLHAPVGEEDDVALGDLIEDGDAASPVESAAFLLLREHLEAVLSTLGERERKVVQLRYGLADGRPRTLEEIGRIFGVTRERIRQIESKTLNKLRDHAFADQLRGYLD
>NC_016582.1|WP_014179927.1|8769319_8771311_+|DNA-primase
MAGRINDDDVKAVRDAVPIDAVVSEYLQLRNAGGGNLKGLCPFHDEKSPSFQVSPSKGLFYCFGCQEGGDTVDFIMKIDHLSFAETIERLASQAGITLRYEQGSATPGRQQGERTRLVEAHKAAAQFYVEQLDSPEAEIGRRFLAERGFDQAAAQHFGVGYSPAGWDHLVRFLRGRGFTDKELILSGLAQESRRNPIDRFRGRLMWPIRDITGEVVGFGARKLRDDDNGPKYLNTPETPLYKKSHVLYGIDLAKKEIAKTSRAVVVEGYTDVMACHLAGVTTAIATCGTAFGGDHIKILRRLLMDNSSAEVVFTFDGDAAGQKAALRAFEDDQKFAAETYIAVTPGGMDPCELRLAEGDGAVKELVDSRTQLFEFAIRHILARHNLDTAVGRAAALEEAAPVVAGIKNRSIQHESAVHLAGLLGILDTQFVVRRVAQLAQWARERGQRGGGPQQGGARRGGGPGGGYGGPGQGSGPGQGSGPGAGRAAGPGGGPDGAPQPPRGPALNLRSPAHRVERELLKLALQRPELVSPAFDAYGIDEFTAPPYAAVRRAIEDAGGASAADGDYLARVRDIAPDDTVRAMVHELAVEPPHTRRDPDEAYAGVQLVAVRLAAVNQRIGEVRGALQRLGSGADPDHLAAVQNELWVLQQYGQSLREKGAAAL
>NC_016582.1|WP_014179926.1|8767951_8769232_+|FAD-dependent-oxidoreductase
MVDAHQTFVIVGGGLAGAKAAETLRAEGFTGRVILICDERDHPYERPPLSKGFLTGSQERDSVFVHEPAWYAQADIELHLGQTAVQLDRAAKAVVLGDRTRIHYDRLLLATGAEPRRLDIPGTDLVGVHHLRRLAHAERLRSVLAALGRDNGQLVIAGAGWIGLEVAAAARGYGAEVTIVEPEPTPLHRVVGPELGTLFADLHQEHGVRFHFGARLTEITGQDGVVLAACTDDGEEHPAHDVLAAIGAAPRTALAEASGLEVADRAAGGGIVVDASLRTSDPDIFAAGDVAAAPLAFPGGVEPPGGRVRVEHWANALNGGPAAARAMLGQDVAYDRVPYFFSDQYDVGLEYSGYAPPGSYDQVVCRGDVGKRQFIAFWLSEGRLLAGMNVNVWDVVEPIQRLIRSGVRLDANDLANPSVPLESLLP
>NC_016582.1|WP_078610653.1|8766227_8767670_+|deoxyguanosinetriphosphate-triphosphohydrolase
MSRTGPTAPEPSAESAEQAHPTAHPPLQPTESAASAWASPGYEAADLERWAAEPDKRPGRTAFQRDRARVLHSAALRRLAGKTQVVPAVPAAPAADPGPGAGAPAWDATPRTRLTHSLECAQVGRELGAALGCDPDLVEMACLAHDLGHPPFGHNGEQALNEVAEACGGFEGNAQSLRLLARLEPKRFVADPDTGAPVSVGLNLTRAALDAATKYPWPRGGHPSDPGSRKFGVYEDDIPVFAWFRQGAPERRTCFEAQVMDWSDDVAYSVHDVEDGLHAGHLDPGLLLAEPERREVFAVAAARYAPGAEADELAEALDRLLDQEWWPHGYDGSSVAQARLKDATSQLIGRFCLAAEGATRAAYGTGRFTRYGAELVVPREARLECAVLKAVADRYVMQRADQEAVRADQRVIIAELGEALTARAPLGLDPQFRALYDEADAAGDDTARLRAIVDQIAALTDTSARTLHARLTAPRRLRRP
>NC_016582.1|WP_055414027.1|8765304_8766231_+|sirohydrochlorin-chelatase
MTALPHPGPAAPSGPLDSTAQLMTRITAQLSAQLGRLNVGGTRRRPRPATPHRPPTLVAVAHGSRDPEALRTVTALVDRVRALRPDLPVRLGHVELNDPLLADTLAALRGEAVLVPLLLGRGYHIKRDLPDAVAAAPHLSVRMAAPLGPHPLLAEALHTRLTEAGWPSGGLSGGPSGGLSGGLSGAGVVLAAAGSRDRDSAADTARTAALLSARLGGVPVLPGYASAAAPTVAEAVRALTDMGRGRRIAVASYFAAPGRFATQCAAAAPGIASGPLGDHPAVARLVVHRYEQALASAPMSHPAVTVGV
>NC_016582.1|WP_043491704.1|8763021_8765124_-|molybdopterin-oxidoreductase-family-protein
MTPDPAVNTHCPYCSLQCGMALRPAPGEGRAEVVEVVERTAFPVNRGALCGKGRTAPAVLSSQVRLTEPLVRRPDTGRLEPATWEEALDRVAEALTGTAQAHGQDAVGVFGGGGLTNEKAYALGKFARVVLGTSQIDYNGRFCMSSAAAAHNKAFGLDRGLPFPLADVARTGCVILVGSNLAETMPPALRYLTELKESGGKLIVIDPRRTRTAEQADLHLAPRPGTDLALALGLLHLVVAEGRVDEEFIARRTNGWPEARAAAMAHWPEMVERITGVPVPELREAMRMFCDAETSMVLTARGPEQQSKGTDTVGAWINLCLATGRAGRPLSGYGCLTGQGNGQGGREHGQKADQLPGYRKLDDPAARAHVAGVWGVDPDTLPGPGRSAYELLDALGGDVRALLLMGSNPVVSAPRAAHIEARLRSLDFMAVADVVLSETAALADVVLPVTQWAEETGTTTNLEGRVILRRTAVTPPPGVRSDLEVLHGLAARLGWEKGFPTDPEEVFDELRRASAGGAADYSGITYRRITEEDGVFWPCPEEPHPGTPRLFLDRFATDDGRARFVPVSHRPAAEEPDAEYPLFLTTGRVLSQYQSGAQTRRVEELNRAAPGPFVQLHPQLAERLGAAEGDPLAVVSRRGRAVAPARISRDIRPDTVFMPFHWAGEGRANALTNPALDPVSRMPEFKVCAVRVERMERAPG
>NC_016582.1|WP_055414304.1|8762565_8763000_+|VOC-family-protein
MLHHVELWVPDIHRALASLGWLLEALGYVAFQNWDSGRSWRLGPTYLVIEQSPALTAHQHDRCRPGLNHLAFHVEDAAAVDKLTADAAHHGWHLLFPDQHPYAGGRQHYAAYLENDDGFEVELVAIMPPDRTGVGTDAHANVTP
>NC_016582.1|WP_014179920.1|8761318_8762317_+|adenosine-deaminase
MPPTPPPIPKAELHLHIEGTLEPELAFALAERNGVELPYATQDELRAAYSFTDLQDFLDLYYALMAVLRTEGDFADLTNAYLARARAQGVRHAEIFFDPQAHTARGVAIGTVIDGLTRALDAAEQTYGITTRLIMCFLRDESAESALEIFESARPYLDRLTAVGLDSAEVGNPPSKFREVYARAREAGLKCVAHAGEEGPPAYVWEALDILGVDRVDHGVRSLEDEALVARLVADQVPLTVCPLSNVRLRVIDRLEDHPLRAMLDAGLLVTVNSDDPAYFGGYAGDNFDAVRDALRLDGATLRALARNSFRASFLDEGARAAYLKEVDAYEG
>NC_016582.1|WP_014179931.1|8776344_8777307_-|sigma-70-family-RNA-polymerase-sigma-factor
MDSTATDRFDTSRFEASRNRLASLAYRLLGSAADAEDAVQDAFLHWQAADRQRIKVPEAWLTKVVTNLCLDRLRSAQARRERTAGAWLPEPLLDGDPMLGPADTFEQRESVSLAVLTLMERLSPLERAVYVLREAFSYSHAEIAEILDITESASQQHLHRARHRITAARRRGGGEVDPASARRIVEEFLAAASSGRTERLVALLTDDATAISDSNGAGLTKTLLRYDTPQRIAAVARAGFKPTPAKRRLVGGTPAIHYALVNAAPAILFVLGDQVIGAVTFDIAGGKIATVRGIAAPTRLVRITEAWRQHGPDTPLITQW
>NC_016582.1|WP_014179932.1|8777342_8778542_-|FAD-dependent-oxidoreductase
MKHRIVVLGAGYAGSYVAGTLARRLSPADTEITVINAEPDFVQRLRLHQLAAGQEIEAPQLADVFAGTGIELRLARVTAVDPQRQVVAVAGADGGGEFGYDTLVHALGSHGDDCGVPGVAEHAFDVAARPSALRLRERLDSLGRRDEGGSVLVVGDGLTGIETATEIAESRPGLSVTLVARGELGARLSAGARGHLRQACDRLGITVLEHTEVEAVEAARVLCADGTVLASDVTVWTAGFAVDPIAAAGGLEVTEDGRIVVDRIMRSVSYPNVYAVGDSAYAIGDNGRPLPMSCASAGYTGMQATAAIVGRLTGRKIPNTKLEYLGNHISLGRRDGILQMVDDEGQAKPKHVGGRKAARIKSGILKMSLWTTSHPTFGLPKRKRRLAVAPDASVEKAFA
>NC_016582.1|WP_014179936.1|8781307_8781631_+|hypothetical-protein
MLATGRYADAVQADHGAAVAPGARGVPFTVLGDRFAIPGAAGTRQYTAVIDQAWGRSMADASMAPPLRLVETGPDGGWCDAATGICTTVAADREGPLPESEAAASGM
>NC_016582.1|WP_014179937.1|8781731_8782322_+|TetR/AcrR-family-transcriptional-regulator
MAEQSTARGSRFTPLRAAQLYDAVLDLLREVGYEALSMEAVATRARFSKATLYRDWGGKPQLVAAAVEFRRPTRIDLIDTGSLRGDLYVMVEHADDNQLARDAALQLSVGHAIYDNPELRRTLREVRLNPALDDIGAILRRGVHRGEVAADNPALDLVPPMLVSLIVARPLLSDTAMTQDDLRRSMEALVFPALGI
>NC_016582.1|WP_014179938.1|8782592_8784893_+|MMPL-family-transporter
MAIFLYRLGNTAFRRRPVVLLVWLALLGAAIIAALSAPATKALPFTLPGAESQKAFDLLDQRFPGSASDGATARIVFKAPEGQTMTTAANKAEVQKVTEEIASGSDQVASAVDPYTAGAISKDGSTAYISVTYKVTAAEVGSDSHDALDKTVEQARESGLTVEAGGNAVKVASHGAAAEVIGVIVAAIVLVITFGSLVAAGLSLLTALIGVGIGFLTLTALNSPLELGDNAGVLALMLGLAVGIDYALFIVSRYRSELAEGHPKQEAAARATGTAGSAVVFAGLTVIIALAGLAVVNIPMLTKMGLAAAGSVTIAVIIAVTLVPAMLGFAGDRVLSKTGKNKAGKNKVAKSRAGRNKAGENEAGKNEEEPAAADSTAKVPMGLRWAQFVLRRPAAVLLAGVVGLGVIAIPSASMTLGLPDDGAQPSDTTQRRAYDLLSEGFGVGFNGPLVVVVDAAGSDDPKTVASEVVSRISKLDDVAAVAPARFNQTGNTAIVTTIPSSKPASEATEKLVERIRDTGTAIEKDTGARLLVTGQTAVNVDFSQKVNDSLIPYLALVVGLAFLLLMAVFRSVLVPLKAALGFLLSVLAALGAVVAVFQWGWLASAIGVEDTGPIMSLMPIFMVGIVFGLAMDYEVFLVTRMREAYVHGEGPAQAVLTGFRDGGRVVTAAAVIMIAVFSGFIGASGAMIKTIGFGLAVAVLFDAFVVRMAIVPAVLALLGKSAWWLPTWLDKILPNVDVEGEKLAKSPAPEPGSGPGADDHPQPVRV
>NC_016582.1|WP_014179939.1|8785025_8785814_+|response-regulator-transcription-factor
MITVLLADPHALHRLGLRTLLGPRPGLTIAGEATTGAETARMHERLRPDVVLLGSGLPPTDVTTTVRRLRQTRTPDSGPPRILVLSSAHRDEHAYDVLRAGADGFLPATTTPDELIAALFTVAAGDAVVSPGLARALIHAVRHGPRPEVPIAKGRLEDLTERERDILVAVASGRSNAEIAAQLSIATTTVKSHVSRILTKIGARARVQAVVFAYESGLVRPPLTPADPSPSPSHRMTNHEEPTCTYFSSRATPPSPNRWNVA
>NC_016582.1|WP_014179940.1|8786102_8787137_-|amidohydrolase
MTDDKLDAFCHILPRDYADRLFALDGVPAVANLRKRIMNIPSLVDLDVRFRQLDEFPGYRQIINLAAPPVEDFGTPAVSTDFARRGNDGLAELVDKHPDRFAGFCAAVALNDVNSAVAELDRAVGQLGAVGVQIYTHVQGHPLDEDRFEPFWKRCAELDLLVQVHPCRNSGWADYPTEERSKYEIWWTFGWEYDLSAFMARIVFSGVLERYPNLKFLIHHGGSMVPHFSGRVGPGWDQLGSRTPAHQQEDVTGYPLTKRPVDYFKMFYADTALFGAVHALRCAVEFFGPERVLFGSDSPYDPEKGPGYIRSAIANVEELDLTEAEKAAIYGNNVRRLLGSRLTR
>NC_016582.1|WP_014179941.1|8787229_8788264_-|LacI-family-DNA-binding-transcriptional-regulator
MTARSADGGRKKRPTLADVARRAGVNPSTVSRALDGRHPFSRSASAERIRGIAQEIGYTPDPSAASLRRQSTRTVGVIVPRLTDTVMAMLYEEIAAACQEQGLLALVATTGDDPAAERDSGRLLLERRVDAMILTTARLDGQGEFIGTLAEQQVPYALAMRTDGRGPAAVGDDRLGGHLATRHLIDLGHTRIAVVAGPSHASSALGRTAGFREAMAEAGVDVDDDLVRPSGFSMESGEEIATQLLARTDPPTAVLCVNDNTAIGVMAAARRRGLRIPEDLSLVGYNDTPIAARLPVALTSVRVPFRDIAQGAVALVQQAIDGKPPQTLTYAPTLIPRSSATRLT
>NC_016582.1|WP_014179942.1|8788481_8789804_+|MFS-transporter
MTETSTSPQQSPTPTAPLYSRRETVLILAFALLGTLFDGAEINLVGYPMAYIADSLHVSTIEIISIATYQGFASIAGGFLFGWLGDAIGRRKTYAMCVLAFGLAALLGGFATGWTTFLLTRLLAGLGMGGLFGLSFSMFTECWKTRRRGAMGGAIQSMFFVGQIITVGVVFACVSALGHDAGWRTGYKLIGAVSLVVAVAAAFWLPESKHWAEYRRALRAGELPERLRPAKIPFTDLVRDGNARVFLTFSGVATATFVASNAIGAYLSTYLLKGQHLPFGRATVIVLIGYVATILAYTLTGYASDLVSRRRAYLWAGVVGTVGFTWFLTLAATGADHVGVRFWADQTFWALMLCAAGFGGFGVMGVWMSELFPTRLRATGSNSTYYIGRGLGAGVFPLAALGLAGTVPLALGLGVIGPALGLLLSFTAPDRTGRTIQSLE
>NC_016582.1|WP_143675873.1|8790334_8790961_+|hypothetical-protein
MRRPEVPSLMRHWRLVVMLEAQGATEPVDGEVVADEVLPWALLQDSQYSARLPSLFLLRRPQAMGLSSGKRVRCTSEEFRRWQEAALGYAAAVDRVSDEMEAVRERAAHARWWIPGDRRRADETWREVRRRYAEVVREASEAYAPVRDEIRRAIDAEEERIRELLREQGLTLEQWQRRLFSQGPSQGRGNPSGGTATGGTGGFGFGGF

Crispr_ID: NC_016582_18

• CRISPR_ID: NC_016582_18
• CRISPR_location: 9361138-9361276
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016582_18

Consensus_repeat	Method
CCCCGTCGCGCGGCGGGCCGTGTGGGCCGCCGTCGACCGGCGG	CRISPRCasFinder

spacers of NC_016582_18

>18.1|9361181|53|NC_016582|CRISPRCasFinder
GGGGGGGGGGGCGGCCCGCTGCTGGTGCTGGACGAGCCGACCACCGGGATGGC

CRISPR arrays and Neighbor proteins around NC_016582_18

CRISPR arrays

The CRISPR arrays of NC_016582_18

>merge|NC_016582|18|9361138-9361276|CRISPRCasFinder
CCCCGTCGCGCGGCGGGCCGTGTGGGCCGCCGTCGACCGGCGGGGGGGGGGGGGCGGCCCGCTGCTGGTGCTGGACGAGCCGACCACCGGGATGGCCCCCGTCGCGCGGCGGGCCGTGTGGGCCGCCGTCGACCGGCGG

>NC_016582|18|17|9361138-9361276|CRISPRCasFinder
CCCCGTCGCGCGGCGGGCCGTGTGGGCCGCCGTCGACCGGCGG	GGGGGGGGGGGCGGCCCGCTGCTGGTGCTGGACGAGCCGACCACCGGGATGGC
CCCCGTCGCGCGGCGGGCCGTGTGGGCCGCCGTCGACCGGCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014180461.1|9348444_9349383_+|RluA-family-pseudouridine-synthase	unknown	unknown	gnl|CDD|161659
NC_016582.1|WP_014180474.1|9363336_9363831_-|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl|CDD|237976
NC_016582.1|WP_086013772.1|9361775_9362594_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|223912
NC_016582.1|WP_014180469.1|9358634_9358838_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014180462.1|9349379_9349862_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|225064
NC_016582.1|WP_014180468.1|9354969_9358515_+|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl|CDD|235554
NC_016582.1|WP_043487807.1|9362653_9363310_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014180478.1|9367706_9368825_+|histidinol-phosphate-transaminase	unknown	unknown	gnl|CDD|235115
NC_016582.1|WP_014180476.1|9364619_9366215_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014180465.1|9351696_9352530_-|DsbA-family-protein	unknown	unknown	gnl|CDD|372611
NC_016582.1|WP_014180470.1|9359110_9360484_+|NYN-domain-containing-protein	unknown	unknown	gnl|CDD|350235
NC_016582.1|WP_014180475.1|9363845_9364586_-|LON-peptidase-substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|366967
NC_016582.1|WP_014180466.1|9352586_9353267_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014180477.1|9366384_9367710_+|histidinol-dehydrogenase	unknown	unknown	gnl|CDD|234853
NC_016582.1|WP_014180479.1|9368821_9369415_+|imidazoleglycerol-phosphate-dehydratase-HisB	unknown	unknown	gnl|CDD|234873
NC_016582.1|WP_014180463.1|9349858_9350980_-|mechanosensitive-ion-channel	unknown	unknown	gnl|CDD|366370
NC_016582.1|WP_014180480.1|9369411_9369576_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014180464.1|9351024_9351624_+|dienelactone-hydrolase-family-protein	unknown	unknown	gnl|CDD|223489
NC_016582.1|WP_014180467.1|9353438_9354764_-|DUF2252-domain-containing-protein	unknown	unknown	gnl|CDD|313268
NC_016582.1|WP_014180481.1|9369572_9370229_+|imidazole-glycerol-phosphate-synthase-subunit-HisH	unknown	unknown	gnl|CDD|237290

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014180461.1|9348444_9349383_+|RluA-family-pseudouridine-synthase	gnl|CDD|161659	TIGR00005, Ribosomal_large_subunit_pseudouridine_synthase_D, pseudouridine synthase, RluA family. In E. coli, RluD (SfhB) modifies uridine to pseudouridine at 23S RNA U1911, 1915, and 1917, RluC modifies 955, 2504 and 2580, and RluA modifies U746 and tRNA U32. An additional homolog from E. coli outside this family, TruC (SP|Q46918), modifies uracil-65 in transfer RNAs to pseudouridine. [Protein synthesis, tRNA and rRNA base modification].	6.28044e-101
NC_016582.1|WP_086013772.1|9361775_9362594_+|ABC-transporter-permease	gnl|CDD|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	1.35925e-08
NC_016582.1|WP_014180462.1|9349379_9349862_+|GNAT-family-N-acetyltransferase	gnl|CDD|225064	COG2153, ElaA, Predicted acyltransferase [General function prediction only].	7.20155e-20
NC_016582.1|WP_014180468.1|9354969_9358515_+|DNA-polymerase-III-subunit-alpha	gnl|CDD|235554	PRK05673, dnaE, DNA polymerase III subunit alpha; Validated.	0
NC_016582.1|WP_014180478.1|9367706_9368825_+|histidinol-phosphate-transaminase	gnl|CDD|235115	PRK03317, PRK03317, histidinol-phosphate aminotransferase; Provisional.	0
NC_016582.1|WP_014180465.1|9351696_9352530_-|DsbA-family-protein	gnl|CDD|372611	pfam13462, Thioredoxin_4, Thioredoxin.	4.64958e-32
NC_016582.1|WP_014180470.1|9359110_9360484_+|NYN-domain-containing-protein	gnl|CDD|350235	cd10911, PIN_LabA, PIN domain of Synechococcus elongatus LabA (low-amplitude and bright) and related proteins. This subfamily contains Synechococcus elongatus PCC 7942 LabA which participates in cyanobacterial circadian timing, it is required for negative feedback regulation of the autokinase/autophosphatase KaiC, a central component of the circadian clock system, and appears to be necessary for KaiC-dependent repression of gene expression. This subfamily belongs to the LabA-like domain family which includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Also included in the LabA-like domain family are human ZNF451, uncharacterized Bacillus subtilis YqxD, uncharacterized Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously Pseudomonas putida S16 NicB , which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.33218e-11
NC_016582.1|WP_014180475.1|9363845_9364586_-|LON-peptidase-substrate-binding-domain-containing-protein	gnl|CDD|366967	pfam02190, LON_substr_bdg, ATP-dependent protease La (LON) substrate-binding domain. This domain has been shown to be part of the PUA superfamily. This domain represents a general protein and polypeptide interaction domain for the ATP-dependent serine peptidase, LON, Peptidase_S16, pfam05362. ATP-dependent Lon proteases are conserved in all living organisms and catalyze rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins.	2.8896e-37
NC_016582.1|WP_014180474.1|9363336_9363831_-|Cys-tRNA(Pro)-deacylase	gnl|CDD|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	4.07323e-75
NC_016582.1|WP_014180477.1|9366384_9367710_+|histidinol-dehydrogenase	gnl|CDD|234853	PRK00877, hisD, bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Reviewed.	0
NC_016582.1|WP_014180479.1|9368821_9369415_+|imidazoleglycerol-phosphate-dehydratase-HisB	gnl|CDD|234873	PRK00951, hisB, imidazoleglycerol-phosphate dehydratase HisB.	4.13718e-118
NC_016582.1|WP_014180463.1|9349858_9350980_-|mechanosensitive-ion-channel	gnl|CDD|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	4.15616e-27
NC_016582.1|WP_014180464.1|9351024_9351624_+|dienelactone-hydrolase-family-protein	gnl|CDD|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	3.53945e-24
NC_016582.1|WP_014180467.1|9353438_9354764_-|DUF2252-domain-containing-protein	gnl|CDD|313268	pfam10009, DUF2252, Uncharacterized protein conserved in bacteria (DUF2252). This domain, found in various hypothetical bacterial proteins, has no known function.	1.28132e-138
NC_016582.1|WP_014180481.1|9369572_9370229_+|imidazole-glycerol-phosphate-synthase-subunit-HisH	gnl|CDD|237290	PRK13146, hisH, imidazole glycerol phosphate synthase subunit HisH; Provisional.	1.60681e-111

Protein sequences

>NC_016582.1|WP_014180470.1|9359110_9360484_+|NYN-domain-containing-protein
MDRCVVLVDAGYLLGAAASLLAGEPARSRISVDHATLIQGLRERAEAETERPLLRIYWFDGAPDRVPQPEHRRLRVMPRVTVRLGALTRSDGRWAQKGVDAAMHAELTELARNRACSDIVLVTGDGDLLPGLMSAKEHGVAVHLWAVQAADGDYNQSEDLVAEADERRVLDRAWITRAVRAKDLTGPCAPVSEPRPEIAAILSAPLPETAAAATAGAVSGVSGVPGVPGDLAPGRNGAARPGGAPTRAPGGPGGPGRAAAPAGGSGAAASGPGTAPADDTEAGSAPGGRGVPTPKDLAGLGRGPAGGQAGAQPAPSATLRWSSDKGWIERGSGAGLGEPPETAGLPMLAQLTSPEQRWADREEDITTVSGDPFEVGQVFARRWIERLSDPGHLQQLSTEYPRIPHRIDGELLRYAARFGLLAHKDDQIDEHDRYAIRAGFWREIDTRTAAEHAPPAD
>NC_016582.1|WP_014180469.1|9358634_9358838_-|hypothetical-protein
MAKNRNRDRKQQQQQQRQGRGTADRPGEQAQNSQTDAQSQAMQSEGGPATAPSSTARKDRQKSFGHN
>NC_016582.1|WP_014180468.1|9354969_9358515_+|DNA-polymerase-III-subunit-alpha
MTKPPFTHLHVHTQYSLLDGAARLKDMFNACQEMGMTHIAMTDHGNLHGAYDFYQQATGAGITPIIGIEAYVAPESRRYKRRVQWGQPHQKRDDVSGSGGYTHKTIWASNKAGLHNLFRLSSDAYMEGYFVKWPRMDKETIAQWSEGLIASTGCPSGELQTRLRLGQFDEALKAASEYQDIFGKDRYFLELMDHGIEIERRVRDGLLEVGKKLGIPPLVTNDSHYTYSREAVAHDALLCVQTGKNLSDPDRFRFDGTGYYLKSTDEMYAIDSSDAWQEGCRNTLLVAEQIDATGWFEKRDLMPRFDVPEGFTEVSWFQEEVKRGMERRYPAGVPEDRQKQAEYEMDVIIQMGFPGYFLVVADFIMWAKNNGIAVGPGRGSAAGSIVAYAMGITDLDPIDHGLIFERFLNPERVSMPDVDIDFDERRRGEVIRYVTEKYGADKVAQIGTYGTIKAKNAIKDSARVLGYPYAMGDRITKAMPADVLGKGIPLSGITDDKHPRYSEAAEVRGMYENEADVKKVIDTARGIEGLVRQMGVHAAGVIMSSETVTEHVPVFSPKNDGQVVTQWDYPTCESLGLLKMDFLGLRNLTIMDDAVKMVRANKGVDLKLLELPLDDPKTYELLCRGDTLGVFQFDGGPMRSLLRMMKPDNFEDISAVSALYRPGPMGMNSHINYALRKNAQQEITPIHPELEEPLKEVLGITYGLVVYQEQVQKAAQVLAGYSLGQADLLRRAMGKKKKEVLDKEFVPFQKGCRERGYSDAAIQAVWDVLVPFAGYAFNKAHSSAYGLVTYWTAYLKANYPAEYMAALLTSVRDDKDKSAIYLNECRRMGIKVLTPNVNESEANFAAQGDDVILFGLTAVRNVGANVVEAIIRGRKSKGKYSSFPDYLDKVEAVVCNKRTTESLIKAGAFDEMGHTRKGLTAHYETMIDNVVAVKRKEAEGQFDLFGGMGGDDSGGDGPGFGLDVEFSDIEWDKAYLLAQEREMLGLYVSDHPLFGIEHVLNDKADAAIAQLTGGEHADGAIVTIGGIISGLQRKMTKQGNAWAIATVEDLAGSIDCMFFPATYQLVSTQLVEDTVVFVKGRLDKREDVPRLVAMELMVPDLSEAGANAPVTITIPTVKVTPPLVEKLGEVLTHHRGSTEVRIKLQGARKTTVLRLDRHRVTADPALFGDLKVLLGPACLAG
>NC_016582.1|WP_014180467.1|9353438_9354764_-|DUF2252-domain-containing-protein
MPTQQTQAEQRGEHILAVFDTAFGELLAADPAAFRVKFRKMAASAFAFYRGTAGLFYADVEQEREGGPYLDDRTGRVWIHGDLHAENFGTYMDANGRLIFNVNDFDEAYVGPFTWDLKRFAASVALIGYTKALSDEKISELVRIYAASYRERIHALATGAKNDEVPPFTLETAEGPLLDALRDARSLTRFGLLDSMTTIRDFERRFASGGGSVELDAATRYKVLAAFDGYLETLPESSLARPDSYRVKDVVGRRGIGIGSAGLPSYNILLEGNSDALENDVVIYMKQAQTPAVSRHITDERVRSYFHHEGHRTVISQRALQAHADPWLGWTELDGSGQLVAEISPYAVDLDWSDIDDPAEIAAVVADLGRATATMHAAADDQSGHSLVPFSTERAIDAVIAADEGGFAELLVDFAHSYGARARADHQIFVDLFRNGRIPGL
>NC_016582.1|WP_014180466.1|9352586_9353267_-|hypothetical-protein
MDGTGPLLRALRAALFTALCVTLSSAAHVLLSSAPLPLTTVAALSVVVFVIAYALAGRERGYWSIAALLVPLELAADTVFTTGQSACYGPSGGPVAGSLRALGVDLLCGSGGVGSPLARVAGPDGAGAVTAAVGSATPWLLLAAHIAVGLLAAAWLRRGEAAVARLLTSLTTFAFRPLLLAVAVVTAAFAPRRRSSRPIGPPSPAPALPLLVHSVVRRGPPCSATA
>NC_016582.1|WP_014180465.1|9351696_9352530_-|DsbA-family-protein
MSNRNSHQNKQAARERMRTERERQAKKERARRQLVVGGAVVAILAIAGGIGYAVTQMNGGGNASKEWKAAAEKTALVKPAHTTGPQGTTVVIGDKNAKNTLHVYEDMRCPICAEFEQYTGTTVAKDIKNGTFKAQFTMGTFLDDKQDIIGAGSKNALSALGAALNVSPDAFLEYKSALFSAKNHPKETDDSFAGDQKLIAIAQQVKELKGNKTFEKAVTNGTYDRWALAMSKTFDDTKDVTGTPTLKLNGKILSVDGQGVPLTPDQFNPLVQQNLKK
>NC_016582.1|WP_014180464.1|9351024_9351624_+|dienelactone-hydrolase-family-protein
MTRSPILLLHSMYGLRPAVHAAADRLRAAGHEVHVPDLFEGRTADSAEDGMALKEEIGKDELLHRAVVAAAPLSDRGVVYAGFSLGGSIAQNLALGDEKARGLLLLHGTSDIADDATADGLPVQLHVADPDPFEPHDWLNAWYLRMGRAGADVEIYRYPGAGHLFTDPELPDYDEEAAEATWKVALGFLAEVTEAAEQR
>NC_016582.1|WP_014180463.1|9349858_9350980_-|mechanosensitive-ion-channel
MEDVLRPLLVIGGSLAITLSVGWAVDRLLQRTDARHAETPLWGLLRRCRLPLQVTVCSALLRGSYDKTHARVVREHGSGIAQLLALVLIAATAWLAVRVSAAVVESSYRRYAASAHDPARVRRVRTQVTLIQRVVTAIVGVVAASAMLLTFPAMRTVGTSMLASAGILGIVAGVAAQSTLGNLFAGLQIAFGDMVRIGDTVVVDGEWGTVEEITLTFLSVRTWDERRITMPVSYFTGKPFENWSRGGAQKTGAVVFHLDHSAPVAEMRVRLGEIVRKSPAWDGRDWSLAVTDTTPSTMVVRALVTARDADDAWTVRCEVREQMITWLREHHPYALPRITTATIQPPLPAADSEDRLTRFGGDLHKDGTHPRQN
>NC_016582.1|WP_014180462.1|9349379_9349862_+|GNAT-family-N-acetyltransferase
MTYRIEVVGADALEACRGVRREVFVVEQRIPESEEMDEYDAHAVHLLATGPQGPTGTVRFLHGAAADKKYGHAGVDGATTAVLGRLAVLPAARGTGLGADLVRAVEAEALRRGLAEVYLEAQTHALGFYERLGYAAYGPEFDEGSGIPHRAMRRALQPRH
>NC_016582.1|WP_014180461.1|9348444_9349383_+|RluA-family-pseudouridine-synthase
MSTIPEIRTLPVPDGLEGERVDAAIARMFGFSRTKAAELAAAGKVQVDGSVAGKSDRVSGGAWLEVEMPQAAPPVRIVAEPVEGMEIVHDDEHIVVVDKPVGVAAHPSPGWTGPTVIGGLAAAGFRVSTSGAAERQGIVHRLDVGTSGLMVVAKSELAYTLLKQQFRERTVDKRYQALVQGHPDPLSGTIDAPIGRHPQHDYKWAVTAEGKPSVTHYDLIEAFRAASLLDIKLETGRTHQIRVHMAAHRHPCVGDLTYGADPTLAKRLQLTRQWLHAVRLGFEHPGGGWVEFESRYPDDLQRALDTVRADSA
>NC_016582.1|WP_086013772.1|9361775_9362594_+|ABC-transporter-permease
MSGGEALAQAAEAPWPGGDAAPAPLAARARLLPALAAVYRAQLSRARVARIPLLFVATFQSVGIMILMRGVVDGGVEARSVVAGSSVLVVAFVALNLLAQYFGQLRASGGLDHYATLPVPPAAVVLGAAAAYASFTAPGTLVTAVVGSVLFQLPMTHLWVLVAVIPLSGAALAGLGAALGLLAPRQELATLCGQLGMSAALLLGVLPAERMPAPVSYARDVLPSTYGVEALARSFDGNPDWLVVCADLGVCAGVAVVSLTAATWAYRRAAVR
>NC_016582.1|WP_043487807.1|9362653_9363310_+|hypothetical-protein
MTAPLTPHDQPGQPSPHDPSPLGGAVPYPTAPDPSGPGPSAPGHSEPGPELRAELVQAALVAIGVAVSGVLLGLVWLWLAPRIPLVWIGDGIYPKDAEGEQAMGADGVFTLWALAFGAVSAALVFLFFRRGGVALVVGLAIGGVLASVIAWRLGVWLGPEAGIEAHAKAVGKGVTFDAPLKLGAKGALLAWSFAAMAVHLGLTSLFGPRDEEPAQPAG
>NC_016582.1|WP_014180474.1|9363336_9363831_-|Cys-tRNA(Pro)-deacylase
MAKKKTSAGTPATTALTAAGTAFTVHAYEHDPAAPSYGEEAAQALGVDPARVFKTLIASVDGGLTVAIVPVSATLDLKALAAAVGGKRAAMADPAAAERTTGYVLGGISPLGQRKRLPTALDASAADHETVCVSAGRRGLEVELSPTDLAALTDAVLAPIARNS
>NC_016582.1|WP_014180475.1|9363845_9364586_-|LON-peptidase-substrate-binding-domain-containing-protein
MTSARLPLFPLNTVLFPGLVMPLNVFEQRYRAMMRELLAMPEDAPRRFGVIAIRDGREVAPTAIGLPDPTADPERGAAAGFGPEPMKSFHAVGCVADAATIREQKDGTFEVLATGTTRFELRSVDASGPYLTAEIDELDEKPGDGAGALASGVVRAFRTYQKRLAGARERTLAAQQDLPGEPSVLSYLVAAAAVLDTPTKQRLLQAPDTATRLAEELKLLRAESAVIGKLPSLPAVDLTRHPTSPN
>NC_016582.1|WP_014180476.1|9364619_9366215_-|hypothetical-protein
MTEPRDGDPPPGLDLTTAEWGMWQAFRNGSTHDLRTSHPQRNDPSGPYAWGPERSVRARVVALLLLDGPPPQPGRVAALKLNGVHITGTLDLAGGTVEPYVEMKNCRFEQEVLLPEAHFTTLRLVGCALPRLEAARVRTEGDLHLPRCVVEHGIRLTDAHIGTDLLLNQLVVRRDRRGQSISADGLTVGQDLQAEMIESHGELSMRGAQIGVSLSLRGAQLHNPYGRRALNAPQLTVERSLYLTAAGVSSYGSGSTPPYGTSNTPTRGTRIQRFECEGGIRLDDGRFNDAVDFDQARFVMENDQELSLRRIQTPELRFVGERPQRGRVILSGARVVNLVDKSVSWPGPGGLTMAGFSYECLIPVGHFPLSRRLEWVAAATPEFSRGPYEMLATAMRTSGEDAEAREVLLAKERRRRETLPPAGKLWGYLQDWTVAYGYRPGRAAVWMAVLWAIGSVFFAHNRPDPIKPGESPNWNASLYTLDLLLPVIDLGQDGYWKPDGAVQWAAIVMVMLGWILATTVAAGASRLLRRQ
>NC_016582.1|WP_014180477.1|9366384_9367710_+|histidinol-dehydrogenase
MISRIDLRGAAFPEGGIDRDLLPRAELDVEAALEKVRPICDDVRHRGTAALIDYAQRFDGVTIERVRVPQEALTRALEELDPAVRAALEESIRRARLVHREQRRADHTTQVVPGGTVTERWVPVERVGLYVPGGRSVYPSSVVMNVVPAQEAGVGSMAVASPPQRDFDGLPHPTILAACALLGVDEVYAAGGAQAIAMFAYGTEECRPVSLVTGPGNIWVAAAKRLLKGRIGIDAEAGPTEIAILADATADPVHVAADLISQAEHDPLAASVLVTDSEELAAAVEKELEAQVAATRHVEDRIRPALTGRQSGIVLVDGIDQGLAVVDAYAAEHLEIQTRDAAAVAARVRNAGAVFVGPYAPVSLGDYAAGSNHVLPTGGCACHSSGLSVQSFLRGIHVVDYTREALAEVAGHVVTLAEAEDLPAHGAAVKARFDWKVPGDK
>NC_016582.1|WP_014180478.1|9367706_9368825_+|histidinol-phosphate-transaminase
MTRIDDLPIRDELRGKSPYGAPQLDVPVRLNTNENPYELPETLVARISERVAEAARHLNRYPDRDAIELRTELAKYLTRTAGHEVGVANVWAANGSNEVLQQLLQTFGGPGRTAIGFEPSYSMHALISRGTGTGWISGPRNADYTIDVDAACAAITEHRPDVVFITSPNNPTGTAVEAETVLALHDAAQRARAKAAGALVVIDEAYGEFSHRPSLLPLIEGRPRLVLSRTMSKAFGAAGLRLGYLAADPAVVDAVQLVRLPYHLSTVTQATALAALEHTDTLLGYVEALKAERDRLVRELRALGCEVTESDANFVQFGRFEDAQAAWQALLERGVLVRDLGVPGMLRVTAGTPAENDAFLDAVRELMKETSA
>NC_016582.1|WP_014180479.1|9368821_9369415_+|imidazoleglycerol-phosphate-dehydratase-HisB
MTRVGRVERTTKETSVVVEIDLDGVGKVDVSTGVGFYDHMLDQLGRHGLFDLTVKTEGDLHIDTHHTIEDTALALGAAFKQALGDKVGIYRFGNCTVPLDESLAQVTVDLSGRPYLVHSEPENMAPMIGTYDTTMTRHILESFVAQAQIALHVHVPYGRNAHHIVECQFKALARALRYASERDPRAAGILPSTKGAL
>NC_016582.1|WP_014180480.1|9369411_9369576_+|hypothetical-protein
MSGLSTAFIVLGLFLLGGVYSFVKQGLPKSVIVLLGIGAAMSLMAGILRLEVWN
>NC_016582.1|WP_014180481.1|9369572_9370229_+|imidazole-glycerol-phosphate-synthase-subunit-HisH
MTAGAKKAAKKVVVFDYGFGNVRSAERALAHVGADVEITRDYDRATAADGLLVPGVGAFAACMKGLREARGDWLVGRRLAGGRPVMGICVGMQILFGRGIEHGVEAEGLDEWPGTVEQLNAPVVPHMGWNTVKAPEDSQLFAGLDEDARYYFVHSYAVRTWELEVTNPNIRAPKVTWATHGEPFVAAVENGPLWATQFHPEKSGDAGAQLLRNWLDTL

Crispr_ID: NC_016582_19

• CRISPR_ID: NC_016582_19
• CRISPR_location: 9669666-9669936
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NC_016582_19

Consensus_repeat	Method
GGGNGGTGTGGCCCAGCGGNN	CRT

spacers of NC_016582_19

>19.1|9669685|44|NC_016582|CRT
GTCGGTGATGGCTGGGATCCGGCCCTGCGGGCCCCGGCGGATGC
>19.2|9669748|44|NC_016582|CRT
GTCGGTGATGGCTGTGATCCGGCCGTGCGGGCCCCGGCGGATGC
>19.3|9669811|44|NC_016582|CRT
ATCGGTGACGGTGACCGGGAGGCCCGCCGCGTCGGTGGTGACGT
>19.4|9669874|44|NC_016582|CRT
ATCCGTGATCGACGACAGGTGACCGGAAGTGTCATAGGCGTAGT

CRISPR arrays and Neighbor proteins around NC_016582_19

CRISPR arrays

The CRISPR arrays of NC_016582_19

>merge|NC_016582|19|9669666-9669936|CRT
GGGGGGTGTGGCCCAGCGGGTCGGTGATGGCTGGGATCCGGCCCTGCGGGCCCCGGCGGATGCGGGTGGTGTGGCCCAGCGGGTCGGTGATGGCTGTGATCCGGCCGTGCGGGCCCCGGCGGATGCGGGTGGTGTGGCCCAGCGGATCGGTGACGGTGACCGGGAGGCCCGCCGCGTCGGTGGTGACGTGGGTGGTGTGGCCCAGCGGATCCGTGATCGACGACAGGTGACCGGAAGTGTCATAGGCGTAGTGGGTGGTGGCTCCGCTGGG

>NC_016582|19|2|9669666-9669936|CRT
GGGGGGTGTGGCCCAGCGG	GTCGGTGATGGCTGGGATCCGGCCCTGCGGGCCCCGGCGGATGC
GGGTGGTGTGGCCCAGCGG	GTCGGTGATGGCTGTGATCCGGCCGTGCGGGCCCCGGCGGATGC
GGGTGGTGTGGCCCAGCGG	ATCGGTGACGGTGACCGGGAGGCCCGCCGCGTCGGTGGTGACGT
GGGTGGTGTGGCCCAGCGG	ATCCGTGATCGACGACAGGTGACCGGAAGTGTCATAGGCGTAGT
GGGTGGTGGCTCCGCTGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014180739.1|9662476_9663895_-|tyrosine--tRNA-ligase	unknown	unknown	gnl|CDD|235645
NC_016582.1|WP_014180734.1|9658272_9659874_+|cation-acetate-symporter	unknown	unknown	gnl|CDD|271374
NC_016582.1|WP_043492090.1|9673087_9673612_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|224584
NC_016582.1|WP_014180752.1|9677604_9678303_-|FadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225097
NC_016582.1|WP_014180746.1|9673626_9673845_-|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NC_016582.1|WP_014180733.1|9657919_9658276_+|DUF485-domain-containing-protein	unknown	unknown	gnl|CDD|377315
NC_016582.1|WP_043487873.1|9672080_9672632_-|hypothetical-protein	unknown	unknown	gnl|CDD|213356
NC_016582.1|WP_143676006.1|9667167_9667539_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014180748.1|9674868_9675291_+|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_016582.1|WP_014180740.1|9664018_9665419_-|peptidase	unknown	unknown	gnl|CDD|223389
NC_016582.1|WP_043487877.1|9678418_9679714_+|MFS-transporter	unknown	unknown	gnl|CDD|340897
NC_016582.1|WP_014180749.1|9675477_9676182_+|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl|CDD|187594
NC_016582.1|WP_014180736.1|9661044_9661272_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_043492084.1|9661465_9661855_-|DUF3099-domain-containing-protein	unknown	unknown	gnl|CDD|378630
NC_016582.1|WP_014180751.1|9677267_9677600_+|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014180750.1|9676187_9676958_+|enoyl-ACP-reductase-FabI	unknown	unknown	gnl|CDD|236124
NC_016582.1|WP_014180735.1|9660028_9661018_+|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl|CDD|234672
NC_016582.1|WP_014180738.1|9662046_9662331_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl|CDD|225170
NC_016582.1|WP_055414327.1|9673805_9674672_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|379262
NC_016582.1|WP_014180741.1|9665415_9666942_-|TldD/PmbA-family-protein	unknown	unknown	gnl|CDD|223389

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014180739.1|9662476_9663895_-|tyrosine--tRNA-ligase	gnl|CDD|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	1.87408e-120
NC_016582.1|WP_014180734.1|9658272_9659874_+|cation-acetate-symporter	gnl|CDD|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NC_016582.1|WP_043492090.1|9673087_9673612_+|GNAT-family-N-acetyltransferase	gnl|CDD|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	1.79783e-29
NC_016582.1|WP_014180752.1|9677604_9678303_-|FadR-family-transcriptional-regulator	gnl|CDD|225097	COG2186, FadR, Transcriptional regulators [Transcription].	3.30138e-51
NC_016582.1|WP_014180746.1|9673626_9673845_-|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.50786e-21
NC_016582.1|WP_014180733.1|9657919_9658276_+|DUF485-domain-containing-protein	gnl|CDD|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	7.18289e-33
NC_016582.1|WP_043487873.1|9672080_9672632_-|hypothetical-protein	gnl|CDD|213356	cd12822, TmCorA-like, Thermotoga maritima CorA-like family. This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	0.00909806
NC_016582.1|WP_014180748.1|9674868_9675291_+|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	1.88084e-12
NC_016582.1|WP_014180740.1|9664018_9665419_-|peptidase	gnl|CDD|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	6.99481e-40
NC_016582.1|WP_043487877.1|9678418_9679714_+|MFS-transporter	gnl|CDD|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.70693e-117
NC_016582.1|WP_014180749.1|9675477_9676182_+|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl|CDD|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.69158e-124
NC_016582.1|WP_014180741.1|9665415_9666942_-|TldD/PmbA-family-protein	gnl|CDD|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	2.9582e-101
NC_016582.1|WP_043492084.1|9661465_9661855_-|DUF3099-domain-containing-protein	gnl|CDD|378630	pfam11298, DUF3099, Protein of unknown function (DUF3099). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	1.26796e-22
NC_016582.1|WP_014180750.1|9676187_9676958_+|enoyl-ACP-reductase-FabI	gnl|CDD|236124	PRK07889, PRK07889, enoyl-[acyl-carrier-protein] reductase FabI.	6.48682e-174
NC_016582.1|WP_014180735.1|9660028_9661018_+|GTP-3',8-cyclase-MoaA	gnl|CDD|234672	PRK00164, moaA, GTP 3',8-cyclase MoaA.	2.12303e-179
NC_016582.1|WP_014180738.1|9662046_9662331_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl|CDD|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	8.02038e-06
NC_016582.1|WP_055414327.1|9673805_9674672_-|helix-turn-helix-domain-containing-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	3.61864e-08

Protein sequences

>NC_016582.1|WP_143676006.1|9667167_9667539_-|hypothetical-protein
MDYRKLFADVNRRPSAYGLDGSYRQHVAFVTGCDAGNDWGLLVGFPEWLAMKTEAEANVTWSSLVLQVAGLSTASGYPVDEEADSKAAKALFVLLDEFLSQRVGARGASNIISRYVANRQGGT
>NC_016582.1|WP_014180741.1|9665415_9666942_-|TldD/PmbA-family-protein
MPHEIDPSFLALPLRALADAALARARALGADHADFRFERVRSAAWRLRDGKPAGSSDTTDLGYAVRVVHGGTWGFASGVDLSMDAAARVAAQAVAMAKLSGKVIQAAGSDERVELADEPVHADRTWVSAYEINPFDVPDAEKAGLLTDWSERLLRADGVAHADASLLTVQENKFYADTAGTTTTQQRVRVHPQLTAVAVDPESGEFDSMRTLAPPVGRGWEYLTGAGGWDWDAELAEIPELLAEKMRAPSVEAGAYDLVIDPSNLWLTIHESIGHATELDRALGYEAAYAGTSFATFDQLGKLRYGSEIMNVTGDRTAEHGLATIGYDDEGVAAQSWDLVRDGTLVGYQLDRRIAKLTGFERSNGCAFADSPGHVPVQRMANVSLQPAPDGPSTEELIGGVERGLYLVGDRSWSIDMQRYNFQFTAQRAFRIENGRLAGQVRDFAYQATTTDFWGSMAAVGGERTYVLGGAFNCGKAQPGQVAAVSHGCPSALFRNVNILNTTQEAGA
>NC_016582.1|WP_014180740.1|9664018_9665419_-|peptidase
MSGVNKPHEVVERALELSRADGCVVIANESSTANLRWAGNALTTNGVTRGRTLTVVATVDGGQGAASGVISRSAVTAEDLEPLVRAAEAAAREAGPAEDAQPLVEAAGEGAVSAGFTDAPDETSSEVFAAFAPALGESFAQARAGGRELYGFANHEVVTSYLGTSTGLRLRHDQPSGTLELNAKSPDRTRSAWAGQATRDFKDVDPAAIDAELARRLAWAQRKIDLPAGRYETLLPPTAVADLLIYQLWSSAARDAAEGRTVFSKPGGGTRIGEKLTDLPLTLRSDPAAPGLEAAPFVIAHSSGDDASVFDNGLPLTATDWIRDGVLNQLITTRHTAGLTDLPVAPGIDNLILDGGGPRSLEEMVAATERGLLLTCLWYIREVDPATLLLTGLTRDGVYLVEGGEVVGEVNNFRFNDSPVSLLSRATEAGRTERTLPREWGDWFTRAAMPALRVPDFNMSSVSKGV
>NC_016582.1|WP_014180739.1|9662476_9663895_-|tyrosine--tRNA-ligase
MTRLGESVARASALLTADLSSDQTVEKLLEETGSRRYLDLTDLSAKEQAELIAARAVEVLPGVDQLAERIEERRTAGRGLSLKLGIDPTATDVHLGHAVPMIALSRFQRMGHDVTLLIGDFTAKIGDPTGRTAERPPLTDDDIARNLAGYRDQVRPFFDFEKVSFRQNSEWLAPYTFPELLGLLAQVPASQLLQRDDFRNRLAEGSGLTMSELLYPIAQGLDSVALECDIELGGADQLLNLQMGRKLMELRGQQPQLVVTMPLIEGTDGTGAKMSKSKGNYIALSATAEDVFGKIMSIPDRLMAPYLRAWTEWTDSEIDLVKGRLEDRSLHPMDLKKVLAGEMVTALYGLPAAMSARAGFVAQFSKKSFTDVEALPEVDAAEHGAESVATVLSKVLQFQPSASAARRVAKQNGLRLVVETEGGQESAVLTEAQAVRPLAEVVAEVLAGAGLTADSGSVYLKAGRKIARLRGL
>NC_016582.1|WP_014180738.1|9662046_9662331_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MNWLWAIVVGLVLGVIAKAILPGKQPIPLWLTTIYGILGAIVGNAVAGWVGIRDTPGVDWGRHLLQLAGAVLIVAMGTRLYAALGGGRRRRERT
>NC_016582.1|WP_043492084.1|9661465_9661855_-|DUF3099-domain-containing-protein
MRKHSEAEVFRITGARQGLADDVRGRQRRYIISMSIRTVSVILAAVLWNVERHVAIVALVLGVVLPYIAVVIANAGRENATSLPSTFVSAPLRPMLISGQQNGGSGATGAESDVEDAGAPTENGRAERG
>NC_016582.1|WP_014180736.1|9661044_9661272_-|hypothetical-protein
MNTPETDAVICSAKGCRAPAVWVLAWNNPKIHTPERRKTWLACEEHRGYLSDFLGVRGFLKDVVTLEEWSSAADH
>NC_016582.1|WP_014180735.1|9660028_9661018_+|GTP-3',8-cyclase-MoaA
MLIDTYGRIATDLRVSLTDRCNLRCTYCMPEEGLQWLAKPDLLTDDEIVRLIRIAVTDLGVTEVRFTGGEPLLRPGLVGIVERCAALDPRPQMSLTTNGIGLERTAAALRAAGLDRVNVSLDTLRPEVFQTMTRRKRHADVLRGLEAAGAAGLTPVKVNAVLMPGLNDDEAPDLLAWAIAHQYELRFIEQMPLDAQHGWKRDGMITAGDILASLRTRFELTPEGDEARGSAPAERWLVDGGPARVGVIASVTRPFCRACDRTRLTADGQVRTCLFAREESDLRGALRSGAPDAEIARLWRLAMWGKKAGSGLDDPSFLQPDRPMSAIGG
>NC_016582.1|WP_014180734.1|9658272_9659874_+|cation-acetate-symporter
MSIHQLAVESASDHRPLIITLFSVFVAATLGITVWAGRQTKDATDFYAGGRSFSGFQNGLAISGDYMSAASFLGIAGAIALTGYDGFLYSIGFLVAWLVALLLVAEPLRNTGRYTMGDVLAYRMRQRPVRTAAGVSTIVVSIFYLLAQMAGAGVLVSLLLGITNEAGKILIVVLVGVVMILYVSIGGMKGTTWVQMVKAVMLIAGALLMTFLVLLKFDFNVSELLGEAAKNSKMGHAFLEPGLKYGATGTTKLDFISLGLALVLGTAGLPHILIRFYTVPTAKAARKSVNWAIGIIGVFYLMTIALGFGAAALLDKKTITDSNPAGNTAAPLLADELGGPVLLAVISAVAFATILAVVAGLTLASSSSFAHDLYANVIRKGEATQEEEIKAARWATVGIGIVAIVLGVFARDLNVAGLVALAFAVAASANLPTILYSLFWKRFTTQGALWSIYGGLASSVFLVLFSPVVSGNPKSSMFKDVDFHWFPLENPGLISIPLGFLLGWVGSLLSKEKPDNAKYAELEVRSLTGYGAH
>NC_016582.1|WP_014180733.1|9657919_9658276_+|DUF485-domain-containing-protein
MDTAPASDRPGDQRQQEHPPYAEVQASAEFGELRRAHRSFAFPLTIAFVSWYLLYVLLSNYAGGFMDTKVAGNINVALVFGLGQFLTTFLIAWWYSRHAAAKLDPRSAAIKSSMGSDA
>NC_016582.1|WP_043487873.1|9672080_9672632_-|hypothetical-protein
MTDHGGSSSSGGPKPGDGYKIEIASVRKVLTPLEESVVAARKIKGDWKKLADHIQNSADFDVYDEAEKMLSSWGFGMGRVAEHTDTVVETLRQVIAAYVLADLLRIKDFAPTEDNIAKLPFGEAGLRAWQNGSRPKFDPPPQIYQEPWLDDYGDGGSYDVPTNPRKRYDGGWEVDGGSKGTIA
>NC_016582.1|WP_043492090.1|9673087_9673612_+|GNAT-family-N-acetyltransferase
MVLGDLIRLRPMEPSDAEALWRWNHDPEVMRWMSDGYAQPLSHVRKRLEERPRNAYGEVLYGVEVLADAKLIGVVRLRDAEPETGRAELDIYIGEKEYWGRGYGTDAMRTMCRYGFDKMRLHKITLTVVTENLAAHRVYQKIGFVDEGRLRQEFRRDGRWYDMFTMGLLEGELR
>NC_016582.1|WP_014180746.1|9673626_9673845_-|DUF397-domain-containing-protein
MHTKRDGAGASELTWFKSSYSSGEGGMCVEVAAGPTAIHVRDSKHAQGPQLAFHITEWGAFISSLRAEEFDA
>NC_016582.1|WP_055414327.1|9673805_9674672_-|helix-turn-helix-domain-containing-protein
MADTERPEQGEYGADFLKFLGKQVKLFRERAGLTQPQLGEAIGYSEELVSSVEQGRRVPQPEFLDAADDVLNAFGVLRAAKEEVAKARLPAFFRGAARLEAQATEFHAYENQVVNGLLQTEDYARAVFTMQRPALEEETIEHRVHARMARQELLTRRPAPVMSFVTEEAALRRPCGGASVLRGQLAHLLHVGEMRNIELQVLPTAVEEHAGNGGPFALLEPSSRQMMAYVEVQDIGRLVTDRKAVRTLEQRYGIIRAQALTPRESLDFIEKLRGELCTPSETERARPN
>NC_016582.1|WP_014180748.1|9674868_9675291_+|ATP-binding-protein
MFFTSSRHGARLARRLVVRRLEEWGIPRDSDASHGIALLAGELTANAVSHGHVPGRNFHLRLTVQPPPAPGVRRTPVTARIEVSDARGERRPELRDYVAETMAYQEEHGRGLVLVDALASKWGVTDRTIGKTVWCEYAVE
>NC_016582.1|WP_014180749.1|9675477_9676182_+|3-oxoacyl-[acyl-carrier-protein]-reductase
MSRSVLVTGGNRGIGLAVARAFADAGDKVAITYRSGEPPAGFLAVKCDITEPEQVEQAYKEIEEKHGPVEVLVANAGITRDQLLMRMTEEDFSTVLDTNLTGAFRVVKRANRGMLRARKGRIVLISSVVGLLGSAGQANYAASKAGLVGFARSLARELGSRNITVNVVAPGFVDTDMTRALDEKQREAYVKQVPLARYAQPEEIAASVRFLASEEAAYITGAVIPVDGGLGMGH
>NC_016582.1|WP_014180750.1|9676187_9676958_+|enoyl-ACP-reductase-FabI
MSGILAGKRILVTGVLTEASIAFHAAKLAQDEGAEVILTGFGRVSLVERIAKRLPKPAPVIELDVQNQEHLDGLADKVREHLGEGVDLDGVVHSIAFGPQGAFNFLEGSWEDVSTAVHVSAYSLKALTMACLPVMPRGGSIVGLTFDAQFAWPKYDWMGVAKAALESTSRYLARDLGAKNVRCNLVSAGPIKSMAAKSIPGFEELATVWDNRAPIGWDLSDPEPAGRGVVALLSDWFPRTTGEIVHVDGGVHMMGA
>NC_016582.1|WP_014180751.1|9677267_9677600_+|hypothetical-protein
MRTSRCVAAAVLVAAVVGFIAVASNASNSAAQERPRPREAACSTWVRGSHATASCFNPNPDVDRVQLHVECARWWDPDMDGRSVEVGPAQHVRLADRCWKEIRKAWVSHR
>NC_016582.1|WP_014180752.1|9677604_9678303_-|FadR-family-transcriptional-regulator
MPLTSPRRSALADQVIAQLRAQITSGEWPVGSRIPTEPELVEQLGVARNTVREAVRALAHNGLLDIRQGSGTYVLATSELAGVMHRRFADADPLHVAELRSALETKAAWLAAERRTEQDLKQIDALLDRRERAWASGDAEAFVEADATLHMAVVAASHNDVLEELYADLGGVVRQFLHGDVKGGLRPEAYVDHARLVEAIRAGNGERAAAEASTHPFSCRYADRSGDTRTAR
>NC_016582.1|WP_043487877.1|9678418_9679714_+|MFS-transporter
MADQDLATPDTAAPIRQRSAPEPAALRWRRRLVVLGLVLAAVNLRPTVTSLGPLLEEARADLGMSGTVAGLLTSMPAACFALFGIAAPRLARRWGPGAVVCVGLVAITVGLTVRPLMGGTAGFLAASALAFAGIAVGNVLMPVIVKRWFPDRVGPMTGAYSMALSLGSAVAAAVTVPMTDALGGGWRAGLGAWAVLAGVAVLPWLMLARDRTGQAAATAPDPAPAPDSAAAPASAVPARTRITKSPTAWALAVFFGLQATGAYITMGWMSQVFRDAGVSASTSGLLLAVTMVMGVPLAFVLPSVAARLRTQGPLVAILGAFGLSAYIGLWLAPAEGAWVWAVLLGISNCSFPLALTMIGMRARTAAGVVRLSAFAQSTGYLLSIPGPLLVGALYQHTGGWDLPIALMAGLMLPQIAAGLLAGRDRAVEDEI

Crispr_ID: NC_016582_20

• CRISPR_ID: NC_016582_20
• CRISPR_location: 10510782-10510958
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_016582_20

Consensus_repeat	Method
CGCGCGTCCCGCGCGGGCGCGGGTGCCGC	CRISPRCasFinder

spacers of NC_016582_20

>20.1|10510811|58|NC_016582|CRISPRCasFinder
GTTGCGCCATCCGGGTGAACGGCGGCTCGGCGTCGGGGGTCCGGCGCGGCCCGTCTGC
>20.2|10510898|32|NC_016582|CRISPRCasFinder
AGGGAAACCAGCGACACACCGAGGAACGAGTA

CRISPR arrays and Neighbor proteins around NC_016582_20

CRISPR arrays

The CRISPR arrays of NC_016582_20

>merge|NC_016582|20|10510782-10510958|CRISPRCasFinder
AGCCGGTCCGGCGGGGGCGCCGGGGCCGGGTTGCGCCATCCGGGTGAACGGCGGCTCGGCGTCGGGGGTCCGGCGCGGCCCGTCTGCCGCGCGTCCCGCGCGGGCGCGGGTGCCGCAGGGAAACCAGCGACACACCGAGGAACGAGTACGCGCGTCCCGCGCAGGCGCGGGTGCCGC

>NC_016582|20|18|10510782-10510958|CRISPRCasFinder
AGCCGGTCCGGCGGGGGCGCCGGGGCCGG	GTTGCGCCATCCGGGTGAACGGCGGCTCGGCGTCGGGGGTCCGGCGCGGCCCGTCTGC
CGCGCGTCCCGCGCGGGCGCGGGTGCCGC	AGGGAAACCAGCGACACACCGAGGAACGAGTA
CGCGCGTCCCGCGCAGGCGCGGGTGCCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016582.1|WP_014181436.1|10510970_10511279_-|hypothetical-protein	unknown	unknown	unknown
NC_016582.1|WP_014181428.1|10503718_10505011_-|biotin-synthase-BioB	unknown	unknown	gnl|CDD|235755
NC_016582.1|WP_014181429.1|10505182_10506397_+|8-amino-7-oxononanoate-synthase	unknown	unknown	gnl|CDD|235655
NC_016582.1|WP_014181445.1|10517391_10518969_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|312032
NC_016582.1|WP_014181441.1|10513158_10514880_+|urease-subunit-alpha	unknown	unknown	gnl|CDD|237304
NC_016582.1|WP_014181443.1|10515645_10516359_+|urease-accessory-protein-UreG	unknown	unknown	gnl|CDD|349776
NC_016582.1|WP_014181434.1|10509544_10509943_-|VOC-family-protein	unknown	unknown	gnl|CDD|380093
NC_016582.1|WP_043492434.1|10512001_10512322_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl|CDD|376852
NC_016582.1|WP_014181432.1|10507791_10508220_+|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_016582.1|WP_014181439.1|10512536_10512839_+|urease-subunit-gamma	unknown	unknown	gnl|CDD|183913
NC_016582.1|WP_014181440.1|10512854_10513166_+|urease-subunit-beta	unknown	unknown	gnl|CDD|237303
NC_016582.1|WP_014181435.1|10510028_10510502_-|C40-family-peptidase	unknown	unknown	gnl|CDD|366353
NC_016582.1|WP_043492427.1|10501619_10502333_-|ATP-dependent-dethiobiotin-synthetase-BioD	unknown	unknown	gnl|CDD|234625
NC_016582.1|WP_043492430.1|10506673_10507543_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|379262
NC_016582.1|WP_014181433.1|10508266_10509475_-|hypothetical-protein	unknown	unknown	gnl|CDD|143636
NC_016582.1|WP_043488062.1|10506406_10506664_-|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NC_016582.1|WP_014181442.1|10514896_10515592_+|urease-accessory-protein-UreF	unknown	unknown	gnl|CDD|223900
NC_016582.1|WP_014181427.1|10502391_10503726_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl|CDD|235656
NC_016582.1|WP_014181444.1|10516355_10517261_+|urease-accessory-protein-UreD	unknown	unknown	gnl|CDD|376611
NC_016582.1|WP_014181437.1|10511285_10511921_-|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl|CDD|237133

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016582.1|WP_014181432.1|10507791_10508220_+|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	4.12937e-17
NC_016582.1|WP_014181428.1|10503718_10505011_-|biotin-synthase-BioB	gnl|CDD|235755	PRK06256, PRK06256, biotin synthase; Validated.	5.57277e-180
NC_016582.1|WP_014181429.1|10505182_10506397_+|8-amino-7-oxononanoate-synthase	gnl|CDD|235655	PRK05958, PRK05958, 8-amino-7-oxononanoate synthase; Reviewed.	1.05537e-168
NC_016582.1|WP_014181434.1|10509544_10509943_-|VOC-family-protein	gnl|CDD|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	1.37262e-31
NC_016582.1|WP_014181441.1|10513158_10514880_+|urease-subunit-alpha	gnl|CDD|237304	PRK13206, ureC, urease subunit alpha; Reviewed.	0
NC_016582.1|WP_014181443.1|10515645_10516359_+|urease-accessory-protein-UreG	gnl|CDD|349776	cd05540, UreG, urease accessory protein UreG. UreG is one of the four accessory proteins of urease. Urease is an enzyme which catalyzes the decomposition of urea to form ammonia and carbon dioxide. Bacterial urease is a trimer of three subunits which are encoded by genes ureA, ureB, and ureC. Up to four accessory proteins (ureD, ureE, ureF, and ureG) are required for urease catalytical function. UreG may play an important role in nickel incorporation of the urease metallocenter. UreG is a member of the Fer4_NifH superfamily which contains an ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.	5.24693e-109
NC_016582.1|WP_014181437.1|10511285_10511921_-|ATP-dependent-Clp-protease-proteolytic-subunit	gnl|CDD|237133	PRK12553, PRK12553, ATP-dependent Clp protease proteolytic subunit; Reviewed.	1.28168e-115
NC_016582.1|WP_043492434.1|10512001_10512322_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl|CDD|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	3.38639e-11
NC_016582.1|WP_014181439.1|10512536_10512839_+|urease-subunit-gamma	gnl|CDD|183913	PRK13241, ureA, urease subunit gamma; Provisional.	2.12528e-65
NC_016582.1|WP_014181440.1|10512854_10513166_+|urease-subunit-beta	gnl|CDD|237303	PRK13203, ureB, urease subunit beta; Reviewed.	5.51049e-61
NC_016582.1|WP_014181435.1|10510028_10510502_-|C40-family-peptidase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	1.28218e-24
NC_016582.1|WP_043492427.1|10501619_10502333_-|ATP-dependent-dethiobiotin-synthetase-BioD	gnl|CDD|234625	PRK00090, bioD, ATP-dependent dethiobiotin synthetase BioD.	4.29421e-66
NC_016582.1|WP_014181445.1|10517391_10518969_+|alpha/beta-hydrolase	gnl|CDD|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	1.94767e-24
NC_016582.1|WP_043492430.1|10506673_10507543_-|helix-turn-helix-domain-containing-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	2.45352e-12
NC_016582.1|WP_014181433.1|10508266_10509475_-|hypothetical-protein	gnl|CDD|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	1.5503e-08
NC_016582.1|WP_043488062.1|10506406_10506664_-|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.12745e-14
NC_016582.1|WP_014181442.1|10514896_10515592_+|urease-accessory-protein-UreF	gnl|CDD|223900	COG0830, UreF, Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones].	1.78169e-33
NC_016582.1|WP_014181427.1|10502391_10503726_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl|CDD|235656	PRK05964, PRK05964, adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional.	0
NC_016582.1|WP_014181444.1|10516355_10517261_+|urease-accessory-protein-UreD	gnl|CDD|376611	pfam01774, UreD, UreD urease accessory protein. UreD is a urease accessory protein. Urease pfam00449 hydrolyzes urea into ammonia and carbamic acid. UreD is involved in activation of the urease enzyme via the UreD-UreF-UreG-urease complex and is required for urease nickel metallocenter assembly. See also UreF pfam01730, UreG pfam01495.	5.46274e-34

Protein sequences

>NC_016582.1|WP_014181435.1|10510028_10510502_-|C40-family-peptidase
MNAHIRVPTAVSRAGAVSALTVAAVGGPVAGPGIPQQAEAASAAAKALQVAASKKGAPYTYGAAGPNRFDCSGLTQYAYKRAGKRLPRTAAAQYNRTRRIKAASRHGGDLVFFHSGSSVYHVGLYAGRGRIWHAPKPGTVVRLERIWTKKVWYGKVR
>NC_016582.1|WP_014181434.1|10509544_10509943_-|VOC-family-protein
MSYLNPVRHITFDAHDPYALAQFWSALTGYALEGSEPEDDEVLITSNQTGVPGLLFLRVPDVKQGKNRVHLDIQPPSGTRDAEVERMVSLGASVIDDRRTEDGLGWVVMTDPEGNEFCVERSAVERGLVEPM
>NC_016582.1|WP_014181433.1|10508266_10509475_-|hypothetical-protein
MVTEEFQADRTYDHVYLVFIDTAGYSTIVLSNPRDRAAHAFDLLRERMRTRLAQLAAERRCARSGVWSWRGDGGFFAVHDDSESVARDVALEAAKTFLTLDLIHLRDEFARAGVGGELHLRMAVHKGTIQHTGEGRTGTIHSPDINLAAHLEKATPRDCLAISEDVYRTAGPYAEQFTPVGSHEGKHVYLMAGDGGPQQAARAWLASRGLGGSTTVHAYPERPSSEEKARLLDAASEEVLDMGTALRTSSGRLVTTERPARYRDAVLGLLRRGGIYSCFLLDPSSDAAATLSRQYQEDMTRKIKDSLERFGRFKERYGAEAEGLRVYQTDEFPGFSALAVDVRRPDGLILYSSYLMGTSPYGVIERGDMPHYLISPAAGPVFGRIRELAEARGTTGHVKRVL
>NC_016582.1|WP_014181432.1|10507791_10508220_+|ATP-binding-protein
MADHHEASVTLPSAPVSVTAARRYVTSVLAEWGLPTDAETVGVVRLVVSELATNAVQHTMGQSPTFTVDLRLEREERLSIGVTDSHPRWPKRLPPATHQDNGRGLLIIRSLAAESGGEVSVIPTPEGGKTVWIALPWTVPVG
>NC_016582.1|WP_043492430.1|10506673_10507543_-|helix-turn-helix-domain-containing-protein
MRYGPAVRRRKLGAELRRLRDLAGLTSGEAARRVGWHQSKVSRLETGRSGARPSDVVRLLDVYEVADPELRALLEALCGGGASDPEGSRRGWWYAYRDLLPPAYRDFISLESEASAASTLETTVVPGLLQTPDYARAVTRAALPDLPRPQVDTLVEVRIARQSVLRGARPLRLHAVLDEAALRREVGGPGVMAGQLRHLAEVAALPQVRLQVLPFSAGMPIGITGPFIIFSFSHITDLDVVVLDHLTSSLYLERKEDLRAYSAAFDTLRTNALTVKESLTFITKIGGGA
>NC_016582.1|WP_043488062.1|10506406_10506664_-|DUF397-domain-containing-protein
MSTMSWSLPCDSALRDAQWLRSSYSTGMNNCVETASLPPGLLAVRDSKNTSGPALLFVPEVWLSFVDALRGGALDTGAATRQRES
>NC_016582.1|WP_014181429.1|10505182_10506397_+|8-amino-7-oxononanoate-synthase
MPQDRHDDPFEWIDEESERRSRAGLVRTIKPRPADSPLLDLAGNDYLGLARHPEVTAAAGAAAARWGAGSTGSRLVTGHTELHAALEAELAAFCGFEAALVFSSGYAANLAAVTALSGRDALVLSDAVNHASLIDGCRLSRAEVAVVPHADPEAVRKALETASPAPEAAETAAETPRGSRRPRRRALVVTDSVFSVDGNAAPLPGLAAACRAYGAALVIDDAHGFGVLGDGGRGAPQGAGLAGARDVVVTVTLSKALGSQGGAVLGPARVIEHLVNSARTFIFDTGLNPAAVGAALASLRLLRHEPERPARARALATGLYERLTAAGLSAVRPDASVVSVRAPSPEQAVQWAADCRAAGLAVGCFRPPSVPDGISRLRLTARADLTDQQIEEAADAIVRTAPTA
>NC_016582.1|WP_014181428.1|10503718_10505011_-|biotin-synthase-BioB
MELLKTLVDKGLRRELPTREEALAVLATADDDVLDVVAAAGKVRRAWFGRRVKLNYLVNLKSGLCPEDCSYCSQRLGSRADILKYTWLKPEEAAAAAGAGVSGGAKRVCLVASGRGPTDRDVERVSRTIEAIKEQNEDVEVCACLGLLSDGQAARLREAGADAYNHNLNTSKATYGDITTTHTYADRVTTVQQAQAAGMSACSGLIAGMGETDQDLVDVVFSLRELDPDSVPVNFLIPIEGTPLAEKWQLTPQRCLRILAMVRFVCPDVEVRLAGGREIHLRSLQPLALHLANSIFLGDYLTTEGQAGKDDLAMIADAGFEVEGTDTTTLPTHRADALATARAGCGSHGGAEHVGSEGEAASAGCGSAGGGCAPCGDAAPAAGTAEGAGAATGAEPVPAAAPAGAPTAGARTDLVAVRRRGVGTDLPPNA
>NC_016582.1|WP_014181427.1|10502391_10503726_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MPEPQLTPGKPLTPGELLALDRRHVWHPYGPMPGRRDPLIVESAAGVRLRLAEPAEGRRELVDGMSSWWSAVHGYNHPVLNDAARGQLDRMSHVMFGGLTHEPAVRLAARLVEITPEPLEHVFLADSGSVSVEVAVKMCLQYWRSLGRPDKRRLLTWRGGYHGDTWQPMAVCDPDGGMHHLWSGLLPRQLFADAPPPGVDALPDPAYEAHLRDLIARHAHELAAVIVEPVVQGAGGMRFHSPGLLRVLREACDEHDVLLIFDEIATGFGRTGELFAAGHAGVSPDVMCLGKALTGGYMTLAATLCTPRVADGISRGELPVLAHGPTFMGNPLATAVALASIDLLLGHDWRQEIKRIEAGLRDGLAATAELPGVRDVRVLGAIGVVQLDHALDEAGMAAATRAAVREGVWLRPFRDLLYTMPPYITSDDDVARICTALHAAARAG
>NC_016582.1|WP_043492427.1|10501619_10502333_-|ATP-dependent-dethiobiotin-synthetase-BioD
MPVLVITGTGTEIGKTITTAAVAATALAAGRSVAVLKPAQTGVRADEPGDTAEVARLAGAVTQAELARYPEPLGPATAARRAGRPPVHPYEVAEAAGKLAAEHDLVLVEGAGGLLVRFDEEGGTLADAARLLGAPVLVVVQAGLGTLNTTTLTAEALRARGLDCPGVVIGSWPKAPDLADRCNLADLPEAAGVPLLGALPQGAAALPPADFRAAAPGWLAPELDGTWSAERFAATHG
>NC_016582.1|WP_014181436.1|10510970_10511279_-|hypothetical-protein
MLPPELPPLPALTRAEGALVDGYLGVVDLLARINPSRGSDTYAGLRAAQALVGKATALRDALALMHERGESRLHTTTLERALRVLDGDRRTERVTLPPTPAP
>NC_016582.1|WP_014181437.1|10511285_10511921_-|ATP-dependent-Clp-protease-proteolytic-subunit
MERPTARYVLPEFTERTSNGVRTMDPYSKLLSERIVFLGTQVDDTSANDVIAQLVHLEHASPDQDISLYINSPGGSFSAMTAIYDTMHFVTCDVETICLGQAASAAAVLLAAGTPGKRFALPGARVLIHQPSFSEPIQGTTSDLELQAKEMLRTRALLEELLVRHTGQTAERIRSDIERDKIFNAEDAVSYGLVDRLTQSRKHPRPLRDAR
>NC_016582.1|WP_043492434.1|10512001_10512322_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MAYEIPVTQARAELAELINRVVYGGERVVVTRHGKPLVALVSADDLRRLEEMESDEAGGTGAEEEQVISTVSTVRPAASAPGERRRFGIAAEHRGPDVGDRRRGRG
>NC_016582.1|WP_014181439.1|10512536_10512839_+|urease-subunit-gamma
MQLTPHEQERLLIHVAADVAEKRRARGVILNHPEAVALITAHILEGARDGRTVAELMSSGREVLTREEVMEGVPEMIHDVQAEATFPDGTKLVTVHQPIA
>NC_016582.1|WP_014181440.1|10512854_10513166_+|urease-subunit-beta
MIPGEILHADEPISLNEGRPVTRLTVLNAADRPVQVGSHYHFAEANPGLDFDRAAAHGQRLHIAAGTAVRFEPGIPVEVELVPIAGERVVPGLRGETGGSLDD
>NC_016582.1|WP_014181441.1|10513158_10514880_+|urease-subunit-alpha
MTELSRPAYADLFGPTAGDRIRLADTDLLIEIEEDRAGGPGRAGDEAVFGGGKVIRESMGQSRATRAEGTPDTVITGAVILDHWGVVKADVGLRDGRITGIGKAGNPDTMDGVHPDLVIGPETEVIAGNGKILTAGAIDAHVHFISPTIADEALAAGITTLVGGGTGPAEGTKATTITPGPWHLARMFEALEGYPVNIGLLGKGNTVSREAMYSQLRGGALGFKIHEDWGATPAAIDACLGVCEESGAQLAIHTDTLNEAGFVGDTLAAIAGRSIHAYHTEGAGGGHAPDIITVVSQPNVLPSSTNPTRPHTVNTVEEHLDMLMVCHHLNPAVPEDLAFAESRIRPSTIAAEDILHDLGAISIISSDSQAMGRVGEVVLRTWQTAHVMKRRRGALPGDGRADNHRARRYVAKYTINPAVAQGLDHEIGSVETGKLADLVLWDPAFFGVKPQLVIKGGQIAYAQMGDANASIPTPQPVLPRPMFGAIGRAPATNSLNFVTRTALDDGLVARLGLGKRFAPIRSTRGVTKADMRENDARPHVEVDPDTFTVTIDGEPVDPAPAAELPMAQRYFLF
>NC_016582.1|WP_014181442.1|10514896_10515592_+|urease-accessory-protein-UreF
MPEPTVPAARAALLVLADGRFPAGGHAHSGGAEAAVKAGRIRDAGSLEEFCRGRLHTAGLTAAGLAAAAAAGLDPLVLDEAADARTPAPALRATARRLGRQMMRTARATWPGPELDALAAARPRGAHQPVVLGLAVRAAGASPTDAAHIAAYESVSGPATAAVRLLSLNPFDATAVLARLVPELDQVAARAAEAARRALDEGPDALPAASAPLLDITAETHAAWPVRLFAS
>NC_016582.1|WP_014181443.1|10515645_10516359_+|urease-accessory-protein-UreG
MHLDHADTDIYPQRHTYSSAADPRRPDGTRRALRIGLGGPVGSGKTATVAALCRALRDELSIAVVTNDIYTREDAEFLLRNAVLPATRITAVETGACPHTAIRDDISANLEAIEDLEDAVGPQGGLDIVFVESGGDNLTATFSKGLVDAQIFVIDVAGGDDIPRKGGPGVTTADLLVVNKTDLAPYVGSDLDRMARDARAQRGDLPVAFTSLVAENGVKPVVDWVRDRLAAWSAAHA
>NC_016582.1|WP_014181444.1|10516355_10517261_+|urease-accessory-protein-UreD
MTAPSPPGSGSGSGSGSRVTSATPPVAAASATIRAAARIVAEADGRGGTALPVLAGDGPLALRRTRAVGAEARVTVVGAMSGPLGGDRIGLDVVVGPGARLSVGSAAATIALPGRSGEPAHYDVRLTVGDGATLCWQPEPVISARASDLRMTCRVELAPTARLLLREEQVLGRAGEPPGRLTTRLTVYRAGRPLLDQELGYGPGTPGWDGGAVLAGHRSAGQLLLVDPAFEERPVPVRQLGETAVLTPLAGPAALVTAVAPDALRLRRLLDSASDGGMAGGDAAGWREAAQAGTDGRMFMC
>NC_016582.1|WP_014181445.1|10517391_10518969_+|alpha/beta-hydrolase
MLGAAGGVLTGALIAGALATPMASAKARTPGGAAEARGVQIAAARAAAAGIDWQDCPADWALEKPIQCGYVTVPLDYAKPYGRTIKLAVDRIGNSGSATERQGALIYNPGGPGGSGLKFPRRVTTKNPLWTKTSKAYDFVGFDPRGVGHSAAISCVDPQEYVKAPKADPVPDSEADKRAQRKLAKEYAQGCAERSGWMLPYLTTPNTARDIDVIRAALGEKKLNYLGVSYGTYIGGVYATLFPTHVRRMIVDSVVNPSREKIWYQANLDQDVAFETRWKDWTAWVAKNDATYHIGDTPEKVQKQWETLRAAAKKHPIGGVVGPAELVGFFQSAPYYDSSWAPVAAVWSAYLAGDEKQLVEAAGPDLSDTAGNIASENGNAVYTAVECADAKWPTSWRTWDRDNTRLHTDYPFMTWANAWMNLPCATWDAPQQNPIEVGADKGLPKTLIVQSTRDAATPYDGAVELHKRLKGSRLITEKDAGSHGVTGLVNACINDRVDAYLLNGTVDAADVTCGPHAMPAPAAAK

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_016582_1	1.1|725628|18|NC_016582|CRT	725628-725645	18	NC_016582.1	725024-725041	1	0.944
NC_016582_1	1.2|725682|18|NC_016582|CRT	725682-725699	18	NC_016582.1	725481-725498	1	0.944
NC_016582_1	1.4|725817|18|NC_016582|CRT	725817-725834	18	NC_016582.1	7495124-7495141	1	0.944
NC_016582_1	1.7|725979|18|NC_016582|CRT	725979-725996	18	NC_016582.1	7495124-7495141	1	0.944
NC_016582_4	4.2|3033314|36|NC_016582|CRISPRCasFinder	3033314-3033349	36	NC_016582.1	3028566-3028601	2	0.944
NC_016582_4	4.3|3033377|36|NC_016582|CRISPRCasFinder	3033377-3033412	36	NC_016582.1	3028629-3028664	2	0.944

1. spacer 1.1|725628|18|NC_016582|CRT matches to position: 725024-725041, mismatch: 1, identity: 0.944

gcctctttctccttctgt	CRISPR spacer
gcctccttctccttctgt	Protospacer
*****.************

2. spacer 1.2|725682|18|NC_016582|CRT matches to position: 725481-725498, mismatch: 1, identity: 0.944

gcctccttctccgcctcc	CRISPR spacer
gcctcctgctccgcctcc	Protospacer
******* **********

3. spacer 1.4|725817|18|NC_016582|CRT matches to position: 7495124-7495141, mismatch: 1, identity: 0.944

tgctcctgctcggcctca	CRISPR spacer
tgctcctgctcggccgca	Protospacer
*************** **

4. spacer 1.7|725979|18|NC_016582|CRT matches to position: 7495124-7495141, mismatch: 1, identity: 0.944

tgctcctgctcggcctca	CRISPR spacer
tgctcctgctcggccgca	Protospacer
*************** **

5. spacer 4.2|3033314|36|NC_016582|CRISPRCasFinder matches to position: 3028566-3028601, mismatch: 2, identity: 0.944

cgcgtccgctgcgacccggccgggctccccgtcgag	CRISPR spacer
cgcgtgcgttgcgacccggccgggctccccgtcgag	Protospacer
***** **.***************************

6. spacer 4.3|3033377|36|NC_016582|CRISPRCasFinder matches to position: 3028629-3028664, mismatch: 2, identity: 0.944

acctaccaccgcgacgccttcggccgccccaccgcc	CRISPR spacer
acctaccaccgcgacgccttcggccgccccgccacc	Protospacer
******************************.**.**

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_016582_13	13.1|7095767|31|NC_016582|CRISPRCasFinder	7095767-7095797	31	NC_047861	Bordetella phage vB_BbrM_PHB04, complete genome	75990-76020	4	0.871
NC_016582_20	20.2|10510898|32|NC_016582|CRISPRCasFinder	10510898-10510929	32	NC_018696	Paraburkholderia phenoliruptrix BR3459a plasmid pSYMBR3459, complete sequence	641359-641390	5	0.844
NC_016582_13	13.1|7095767|31|NC_016582|CRISPRCasFinder	7095767-7095797	31	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	501985-502015	6	0.806
NC_016582_17	17.1|8774984|48|NC_016582|CRISPRCasFinder	8774984-8775031	48	NZ_CP018784	Curtobacterium pusillum strain AA3 plasmid pCPAA3, complete sequence	253740-253787	6	0.875
NC_016582_5	5.1|3312221|35|NC_016582|CRISPRCasFinder	3312221-3312255	35	NZ_CP032054	Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence	171538-171572	7	0.8
NC_016582_5	5.1|3312221|35|NC_016582|CRISPRCasFinder	3312221-3312255	35	NZ_CP032054	Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence	880057-880091	7	0.8
NC_016582_5	5.1|3312221|35|NC_016582|CRISPRCasFinder	3312221-3312255	35	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1277960-1277994	7	0.8
NC_016582_5	5.1|3312221|35|NC_016582|CRISPRCasFinder	3312221-3312255	35	NZ_CP016560	Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence	536946-536980	7	0.8
NC_016582_6	6.1|3787678|28|NC_016582|CRISPRCasFinder	3787678-3787705	28	NC_009928	Acaryochloris marina MBIC11017 plasmid pREB3, complete sequence	208130-208157	7	0.75
NC_016582_10	10.1|5802571|32|NC_016582|CRISPRCasFinder	5802571-5802602	32	MN582107	Podoviridae sp. ctDWo9, complete genome	34898-34929	7	0.781
NC_016582_13	13.1|7095767|31|NC_016582|CRISPRCasFinder	7095767-7095797	31	NC_015382	Burkholderia gladioli BSR3 plasmid bgla_1p, complete sequence	23103-23133	7	0.774
NC_016582_13	13.1|7095767|31|NC_016582|CRISPRCasFinder	7095767-7095797	31	NZ_CP054607	Sulfitobacter pseudonitzschiae strain H46 plasmid unnamed8, complete sequence	1106-1136	7	0.774
NC_016582_13	13.1|7095767|31|NC_016582|CRISPRCasFinder	7095767-7095797	31	NZ_CP010679	Phaeobacter gallaeciensis strain P75 plasmid pP75_f, complete sequence	49445-49475	7	0.774
NC_016582_13	13.1|7095767|31|NC_016582|CRISPRCasFinder	7095767-7095797	31	NZ_CP010790	Phaeobacter gallaeciensis strain P63 plasmid pP63_f, complete sequence	49431-49461	7	0.774
NC_016582_13	13.1|7095767|31|NC_016582|CRISPRCasFinder	7095767-7095797	31	NZ_CP045408	Roseovarius sp. THAF9 plasmid pTHAF9_d, complete sequence	39218-39248	7	0.774
NC_016582_13	13.2|7095821|31|NC_016582|CRISPRCasFinder	7095821-7095851	31	NC_022599	Micrococcus sp. V7 plasmid pLMV7, complete sequence	44895-44925	7	0.774
NC_016582_4	4.2|3033314|36|NC_016582|CRISPRCasFinder	3033314-3033349	36	NZ_CP020372	Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs485, complete sequence	150035-150070	8	0.778
NC_016582_8	8.3|4396449|35|NC_016582|CRISPRCasFinder	4396449-4396483	35	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	375097-375131	9	0.743
NC_016582_12	12.1|6934234|34|NC_016582|CRISPRCasFinder	6934234-6934267	34	NC_014310	Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence	1778432-1778465	9	0.735
NC_016582_12	12.1|6934234|34|NC_016582|CRISPRCasFinder	6934234-6934267	34	NZ_CP022760	Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence	1691814-1691847	9	0.735
NC_016582_12	12.1|6934234|34|NC_016582|CRISPRCasFinder	6934234-6934267	34	NZ_CP022789	Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence	1691815-1691848	9	0.735
NC_016582_17	17.1|8774984|48|NC_016582|CRISPRCasFinder	8774984-8775031	48	KY250482	Corynebacterium phage phi16, complete genome	56101-56148	9	0.812
NC_016582_17	17.1|8774984|48|NC_016582|CRISPRCasFinder	8774984-8775031	48	KF017927	Mycobacterium phage Odin, complete genome	4126-4173	9	0.812
NC_016582_17	17.1|8774984|48|NC_016582|CRISPRCasFinder	8774984-8775031	48	MN284903	Mycobacterium phage GaugeLDP, complete genome	5561-5608	9	0.812
NC_016582_13	13.1|7095767|31|NC_016582|CRISPRCasFinder	7095767-7095797	31	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	200075-200105	10	0.677
NC_016582_17	17.1|8774984|48|NC_016582|CRISPRCasFinder	8774984-8775031	48	MK359341	Mycobacterium phage GingkoMaracino, complete genome	3702-3749	10	0.792
NC_016582_17	17.1|8774984|48|NC_016582|CRISPRCasFinder	8774984-8775031	48	MH536825	Mycobacterium phage Ollie, complete genome	3702-3749	10	0.792
NC_016582_17	17.1|8774984|48|NC_016582|CRISPRCasFinder	8774984-8775031	48	MN284900	Mycobacterium phage JeppNRM, complete genome	3867-3914	10	0.792
NC_016582_17	17.1|8774984|48|NC_016582|CRISPRCasFinder	8774984-8775031	48	MH450128	Mycobacterium phage Reba, complete genome	3540-3587	10	0.792
NC_016582_17	17.1|8774984|48|NC_016582|CRISPRCasFinder	8774984-8775031	48	MH371121	Mycobacterium phage Phranny, complete genome	3867-3914	10	0.792
NC_016582_17	17.1|8774984|48|NC_016582|CRISPRCasFinder	8774984-8775031	48	KF279418	Mycobacterium phage Anubis, complete genome	3702-3749	10	0.792
NC_016582_2	2.1|2880443|40|NC_016582|CRISPRCasFinder	2880443-2880482	40	MN234195	Mycobacterium phage Xula, complete genome	13648-13687	11	0.725
NC_016582_2	2.1|2880443|40|NC_016582|CRISPRCasFinder	2880443-2880482	40	HM152765	Mycobacterium phage Island3, complete genome	14020-14059	11	0.725
NC_016582_2	2.1|2880443|40|NC_016582|CRISPRCasFinder	2880443-2880482	40	NC_011291	Mycobacterium phage Brujita, complete genome	14020-14059	11	0.725
NC_016582_8	8.3|4396449|35|NC_016582|CRISPRCasFinder	4396449-4396483	35	NZ_CP013104	Paraburkholderia caribensis strain MWAP64 plasmid 1, complete sequence	349560-349594	11	0.686

1. spacer 13.1|7095767|31|NC_016582|CRISPRCasFinder matches to NC_047861 (Bordetella phage vB_BbrM_PHB04, complete genome) position: , mismatch: 4, identity: 0.871

tctgcgcgacggccggcgtgtacgcctcgtc	CRISPR spacer
actgcgcgacggccggcgtgtgcgccacgcc	Protospacer
 ********************.**** **.*

2. spacer 20.2|10510898|32|NC_016582|CRISPRCasFinder matches to NC_018696 (Paraburkholderia phenoliruptrix BR3459a plasmid pSYMBR3459, complete sequence) position: , mismatch: 5, identity: 0.844

agggaaaccagcgacacaccgagg--aacgagta	CRISPR spacer
agggaaaccggcgacacaccgcggtcaaccag--	Protospacer
*********.*********** **  *** **  

3. spacer 13.1|7095767|31|NC_016582|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 6, identity: 0.806

tctgcgcgacggccggcgtgtacgcctcgtc	CRISPR spacer
gctgcgcgacgggcggcgtggacgcgctgtc	Protospacer
 *********** ******* **** ..***

4. spacer 17.1|8774984|48|NC_016582|CRISPRCasFinder matches to NZ_CP018784 (Curtobacterium pusillum strain AA3 plasmid pCPAA3, complete sequence) position: , mismatch: 6, identity: 0.875

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ttgatcccctgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
*.*.**************************..**************. 

5. spacer 5.1|3312221|35|NC_016582|CRISPRCasFinder matches to NZ_CP032054 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence) position: , mismatch: 7, identity: 0.8

agcggcgacggggacagctgcgtcgaagtcgccgc	CRISPR spacer
agcggcgacggggtcagcggcgtcgacggggctgt	Protospacer
************* **** ******* *  **.*.

6. spacer 5.1|3312221|35|NC_016582|CRISPRCasFinder matches to NZ_CP032054 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence) position: , mismatch: 7, identity: 0.8

agcggcgacggggacagctgcgtcgaagtcgccgc	CRISPR spacer
agcggcgacggggtcagcggcgtcgacggggctgt	Protospacer
************* **** ******* *  **.*.

7. spacer 5.1|3312221|35|NC_016582|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 7, identity: 0.8

agcggcgacggggacagctgcgtcgaagtcgccgc	CRISPR spacer
agcggcgacggggtcagcggcgtcgacggggctgt	Protospacer
************* **** ******* *  **.*.

8. spacer 5.1|3312221|35|NC_016582|CRISPRCasFinder matches to NZ_CP016560 (Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence) position: , mismatch: 7, identity: 0.8

agcggcgacggggacagctgcgtcgaagtcgccgc	CRISPR spacer
agcggcgacggggtcagcggcgtcgacggggctgt	Protospacer
************* **** ******* *  **.*.

9. spacer 6.1|3787678|28|NC_016582|CRISPRCasFinder matches to NC_009928 (Acaryochloris marina MBIC11017 plasmid pREB3, complete sequence) position: , mismatch: 7, identity: 0.75

cgccacgggtgcggcctcctccgccccg	CRISPR spacer
agccacgggtgcagcctcctccaggtct	Protospacer
 ***********.*********.  .* 

10. spacer 10.1|5802571|32|NC_016582|CRISPRCasFinder matches to MN582107 (Podoviridae sp. ctDWo9, complete genome) position: , mismatch: 7, identity: 0.781

-cgccgggcgctctgggttgcgaagatgcccgt	CRISPR spacer
gcgac-cgcgctctgggtggcgaatatgccaat	Protospacer
 ** *  *********** ***** ***** .*

11. spacer 13.1|7095767|31|NC_016582|CRISPRCasFinder matches to NC_015382 (Burkholderia gladioli BSR3 plasmid bgla_1p, complete sequence) position: , mismatch: 7, identity: 0.774

tctgcgcgacggccggcgtgtacgcctcgtc	CRISPR spacer
tcagcgtgacggccggcgtgtaccgcaactc	Protospacer
** ***.****************  *   **

12. spacer 13.1|7095767|31|NC_016582|CRISPRCasFinder matches to NZ_CP054607 (Sulfitobacter pseudonitzschiae strain H46 plasmid unnamed8, complete sequence) position: , mismatch: 7, identity: 0.774

tctgcgcgacggccggcgtgtacgcctcgtc	CRISPR spacer
tttccagcacggccagcgtgttcgcctcgtc	Protospacer
*.* *.  ******.****** *********

13. spacer 13.1|7095767|31|NC_016582|CRISPRCasFinder matches to NZ_CP010679 (Phaeobacter gallaeciensis strain P75 plasmid pP75_f, complete sequence) position: , mismatch: 7, identity: 0.774

tctgcgcgacggccggcgtgtacgcctcgtc	CRISPR spacer
tttccagcacggccagcgtgttcgcctcgtc	Protospacer
*.* *.  ******.****** *********

14. spacer 13.1|7095767|31|NC_016582|CRISPRCasFinder matches to NZ_CP010790 (Phaeobacter gallaeciensis strain P63 plasmid pP63_f, complete sequence) position: , mismatch: 7, identity: 0.774

tctgcgcgacggccggcgtgtacgcctcgtc	CRISPR spacer
tttccagcacggccagcgtgttcgcctcgtc	Protospacer
*.* *.  ******.****** *********

15. spacer 13.1|7095767|31|NC_016582|CRISPRCasFinder matches to NZ_CP045408 (Roseovarius sp. THAF9 plasmid pTHAF9_d, complete sequence) position: , mismatch: 7, identity: 0.774

tctgcgcgacggccggcgtgtacgcctcgtc	CRISPR spacer
tttccagcacggccagcgtgttcgcctcgtc	Protospacer
*.* *.  ******.****** *********

16. spacer 13.2|7095821|31|NC_016582|CRISPRCasFinder matches to NC_022599 (Micrococcus sp. V7 plasmid pLMV7, complete sequence) position: , mismatch: 7, identity: 0.774

tcggcgccgtgggtggtgtctgcgtcccgga---	CRISPR spacer
atggcgccgtcggtggtgtctgcg---gggatct	Protospacer
 .******** *************    ***   

17. spacer 4.2|3033314|36|NC_016582|CRISPRCasFinder matches to NZ_CP020372 (Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs485, complete sequence) position: , mismatch: 8, identity: 0.778

cgcgtccgctgcgacccggccgggct---ccccgtcgag	CRISPR spacer
cgcgtcccctgcgacccggccaggctggacctggcc---	Protospacer
******* *************.****   **. *.*   

18. spacer 8.3|4396449|35|NC_016582|CRISPRCasFinder matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.743

tatccgccgcggcccgcacggccgcgtcacagccg	CRISPR spacer
gcgccgccgcggcccggaccgccgcgtccgcgtcg	Protospacer
   ************* ** ********   *.**

19. spacer 12.1|6934234|34|NC_016582|CRISPRCasFinder matches to NC_014310 (Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence) position: , mismatch: 9, identity: 0.735

cggagtggcggcctgcggagtcacgccctgcggc	CRISPR spacer
gcgcttggccgcctgcggagtgacgccctgtgca	Protospacer
  *  **** *********** ********.*  

20. spacer 12.1|6934234|34|NC_016582|CRISPRCasFinder matches to NZ_CP022760 (Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.735

cggagtggcggcctgcggagtcacgccctgcggc	CRISPR spacer
gcgcttggccgcctgcggagtgacgccctgtgca	Protospacer
  *  **** *********** ********.*  

21. spacer 12.1|6934234|34|NC_016582|CRISPRCasFinder matches to NZ_CP022789 (Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.735

cggagtggcggcctgcggagtcacgccctgcggc	CRISPR spacer
gcgcttggccgcctgcggagtgacgccctgtgca	Protospacer
  *  **** *********** ********.*  

22. spacer 17.1|8774984|48|NC_016582|CRISPRCasFinder matches to KY250482 (Corynebacterium phage phi16, complete genome) position: , mismatch: 9, identity: 0.812

---tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
caattgatcat---tagctcaattggcagagcatccggctgttaaccggac	Protospacer
   *.*.** .   ********************.*************** 

23. spacer 17.1|8774984|48|NC_016582|CRISPRCasFinder matches to KF017927 (Mycobacterium phage Odin, complete genome) position: , mismatch: 9, identity: 0.812

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccaatgacgtgtagctcaattggcagagcacccggctgttaaccggac	Protospacer
.*..*  * *********************..*************** 

24. spacer 17.1|8774984|48|NC_016582|CRISPRCasFinder matches to MN284903 (Mycobacterium phage GaugeLDP, complete genome) position: , mismatch: 9, identity: 0.812

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccactgacgtgtagctcaatcggcagagcatccggctgttaaccggac	Protospacer
.*. *  * ***********.**********.*************** 

25. spacer 13.1|7095767|31|NC_016582|CRISPRCasFinder matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 10, identity: 0.677

tctgcgcgacggccggcgtgtacgcctcgtc	CRISPR spacer
cacccgcgacggccggcgtctgcgcctaagg	Protospacer
. . *************** *.***** .  

26. spacer 17.1|8774984|48|NC_016582|CRISPRCasFinder matches to MK359341 (Mycobacterium phage GingkoMaracino, complete genome) position: , mismatch: 10, identity: 0.792

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccactgacgtgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
.*. *  * *********************..**************. 

27. spacer 17.1|8774984|48|NC_016582|CRISPRCasFinder matches to MH536825 (Mycobacterium phage Ollie, complete genome) position: , mismatch: 10, identity: 0.792

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccactgacgtgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
.*. *  * *********************..**************. 

28. spacer 17.1|8774984|48|NC_016582|CRISPRCasFinder matches to MN284900 (Mycobacterium phage JeppNRM, complete genome) position: , mismatch: 10, identity: 0.792

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccattgacgtgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
.*. *  * *********************..**************. 

29. spacer 17.1|8774984|48|NC_016582|CRISPRCasFinder matches to MH450128 (Mycobacterium phage Reba, complete genome) position: , mismatch: 10, identity: 0.792

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccattgacgtgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
.*. *  * *********************..**************. 

30. spacer 17.1|8774984|48|NC_016582|CRISPRCasFinder matches to MH371121 (Mycobacterium phage Phranny, complete genome) position: , mismatch: 10, identity: 0.792

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccattgacgtgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
.*. *  * *********************..**************. 

31. spacer 17.1|8774984|48|NC_016582|CRISPRCasFinder matches to KF279418 (Mycobacterium phage Anubis, complete genome) position: , mismatch: 10, identity: 0.792

tcggtcccctgtagctcaattggcagagcattcggctgttaaccggag	CRISPR spacer
ccactgacgtgtagctcaattggcagagcacccggctgttaaccgggc	Protospacer
.*. *  * *********************..**************. 

32. spacer 2.1|2880443|40|NC_016582|CRISPRCasFinder matches to MN234195 (Mycobacterium phage Xula, complete genome) position: , mismatch: 11, identity: 0.725

ggtggtg-tggccggcggggtccgtggtggcggtgcggttt	CRISPR spacer
-ccggcgccggccggcgggttcggtggtggcggtgcgccgc	Protospacer
  .**.* .********** ** ************** . .

33. spacer 2.1|2880443|40|NC_016582|CRISPRCasFinder matches to HM152765 (Mycobacterium phage Island3, complete genome) position: , mismatch: 11, identity: 0.725

ggtggtg-tggccggcggggtccgtggtggcggtgcggttt	CRISPR spacer
-ccggcgccggccggcgggttcggtggtggcggtgcgccgc	Protospacer
  .**.* .********** ** ************** . .

34. spacer 2.1|2880443|40|NC_016582|CRISPRCasFinder matches to NC_011291 (Mycobacterium phage Brujita, complete genome) position: , mismatch: 11, identity: 0.725

ggtggtg-tggccggcggggtccgtggtggcggtgcggttt	CRISPR spacer
-ccggcgccggccggcgggttcggtggtggcggtgcgccgc	Protospacer
  .**.* .********** ** ************** . .

35. spacer 8.3|4396449|35|NC_016582|CRISPRCasFinder matches to NZ_CP013104 (Paraburkholderia caribensis strain MWAP64 plasmid 1, complete sequence) position: , mismatch: 11, identity: 0.686

tatccgccgcggcccgcacggccgcgtcacagccg	CRISPR spacer
ctgccgccgcggcctccacggccgcgtcgacttca	Protospacer
.  ***********. ************.   .*.

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	19705 : 83640	58	Marseillevirus(28.57%)	transposase,protease	NA
DBSCAN-SWA_2	534066 : 599853	49	Bacillus_phage(33.33%)	tail,bacteriocin,plate,tRNA	NA
DBSCAN-SWA_3	1637303 : 1727625	68	Bacillus_phage(40.0%)	transposase	NA
DBSCAN-SWA_4	10173037 : 10232574	43	Lactobacillus_phage(33.33%)	integrase,tail,transposase	attL 10161824:10161840|attR 10186360:10186376
DBSCAN-SWA_5	10315826 : 10342311	18	Erysipelothrix_phage(100.0%)	transposase	NA
DBSCAN-SWA_6	10633537 : 10646120	14	Bacillus_phage(100.0%)	integrase,tail,plate	attL 10629315:10629329|attR 10635875:10635889
DBSCAN-SWA_7	11680346 : 11733773	57	Trichoplusia_ni_ascovirus(20.0%)	integrase,transposase,bacteriocin	attL 11690337:11690355|attR 11726672:11726690

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_016582|19705:83640|DBSCAN-SWA
TGTGGATGAAGCGGTGCGCGTGGCCGATCTCCTCTTCCCGGGTGTGGATGTGGAGGTCGAGCGGCTGGTACTCACGGACGCCGAGGTCTGTGTCGACGTACGGTCTCGGGCCGCAGCGGCGGCCTGTCCCGAGTGCGGGCAGAAATCATCGCGAGTGCACTGCTATGACGAGCAGTGCCTGACCGACCGTCCCGTCGCCGGGCCGCGCGTGCGGATCGAGCTGCGGGCACAGCGCCTCGTCTGCGAGAACACCTCTTGCACCCATCGGACATTCACCGAGCAGATACCGGGCCCGACGCGCCGCCACGCCCGCCGTTCTCTACCGACCTGCAGCCACGCTGGGGCATGTTTCGGAAGCCGGGGGGAGTGTCGGTTCTGAAGGGAGGCGTTCGCCGTAGGGTGAGAGGCGGCCGAAGGCGGCCAACGGCCAAGGGAGCCATGTATGACGCGGTACCTGATCTCTTTTGATGACGGCGCGATGACCTTCCCCGAGGAGGAGTTGCCCGAGGTGGCCGAGGCCTCGCTCGAGGTGGTACGTAAGGCTCGGGACGCCGCTGTGTGGGTCTTCGGTGGTGGACTGGAAAGGCAGCAGGCGAGCGTCGTGTCCACCGACGGGACCGTCACCAACGGCCCGTACCCGGAGACCAAGGCGGTGCTCGGCGGGTTTGCGATCATCGATGTGCCCTCACGTGAGGACGCATTGGAGTGGGCTGCCAAGATCGCTGCCGCGTGCCGCTGCGCGCAAGAGGTCCGGGAGATCATGGCCGACCCGACCGTCTGATCGAAGACGACCCCCCGCGGCTGGGTCTGGTTCGGAAGTGGCTTGTGACCTGCGGGATCGGCATGCTGCGAGCCTGTGGGCGACACAGTTGGGCGGCATGATCTGACGGACGAGGCGTGGGCGGTACTCGAGGCGTTGCTGCCGGTCGCAGGGTGCGGTTGTCCGGGGCGGAACCTGCGTCGGCAGGTCGACGGGATCCGGCACCGGGTCCGGGCGGGGTGCCCGTGGCGAGACGTGCCCGAACGGTATGGGCCGTGGTCGAGCCTGTATCGGGCGTTCCGCCGTTACCAGCACGAGGGCGCCTGGAACCAGGTCACAGCCCGCAGTTCGCCGCGGTGCTCGACCAGGTCCGGGTGAGGCGTCCCGGCGGGGCCGGGCGGCCGCGGAGGCGCCCTGACCGGGTCCGGGCGGATAAGGGGTATGCCTCAGCGGCCAATCGGCGCCGGCTTCGGCGGCGCGGGATCGCTGCGACGATCCCGGACAAGAAGGACCAACGCGCCAACCGGCTGGCGAGGGGCTCGAAGGGTGGGCGGCCACCGAAGATCGACTAGAGACATCCGGTAGGAGGCGATCACACATATGACGGACCTGGCCGTCACGGCACCCGACGCGTCATGGAGCGAGGACAACGACTGGCAGAAGCAGGCGTGGCACGTCCTCCTCAGCGGCAAGGAACGCGAGAGCCTGTTCGAGCACGTACGCCGTGAACTCGTACCCCGCCTCGAACGGCCCGAGGATCCGGACAAAGCCCACCGCGACTGGGCTCCCGATGCTCCTCCCTACCGACGAGAAGCCTCGCAGAGCACCCAGCCGATCCCAGTACAGCGCAGTCTCTTCGACGACATCGACCACCAACAGAAGCCCCTCACCCTGGCCCTCACGCCTGGGCAGCGTGCTCGTGACATCCGCCACGCCCTACAGCAAATCCGTGCCATGGTGCCGGTCCCCGCCGTTCCCAATGGGCTCGGACCAGCGGTGGGGTCTGCAATGTGCCCAGCACGCTGCGACCAGTCCTAAGTGGTCGAGTTCGTAAGTCCTTCGGGGGTTGATCATGTAGCGGGCTCGGCGGAGGATTCTTCATGGTGATCGGCGGTGTGCCGGTCGAGTCTGGCCAGTAGATCGTCCAGGTCGGAGGTGGTGAACTTCCACTGGAACGGCTGTGCCGTGGCGTTGTAGCGGTCTTCGAATGTTCGGAGCCGGTCCCTGACCTGGGCGAGGTCGGTGAAGTCGTTGGATGAGACGACCTTGCGTTGGACGACGGAGAAGTAGATCTCCACCTGGTTCAGCCACGAAGCGTGGACCGGGGTGTGGACCATCACCGCGTTCGGGAACGCGCTGGTCAACCGGTCGGCAGCCTTCTTGCCGCGGTGGGAGGAGCCGTTGTCGACGATCCAGAACACGCGTTTCGCGCCGGCGTAGGGCTCGGTGCTCATGACCTGGGTGACCAGGTTCATGAACGGGTCGATGCCGGCCTTGGGTTCGGTGCAGCCGAACACTTTCGCGTGGTGGACGTCGTAGGCGGCCAGGTAGGCCAGGGCGCCGCCGCGTCCGTAAGTGTGGTTGACGCGCATCGCGCGGGCCTGGCCGGGGGCAAGGGTGGGGTGGCAGCGGCAGCGGGCCTGGATGGAGGTCTTCTCGTCTGCGCTGATGACGTACTCGTCCTCGCCGAGCGGGACGCCCTGCCAGGTGCGGGCGTACAAGCCGAGCACCCGCTCGGCCTTGATCCGGAAGTCGGGGTCGGTGATGAAGATCCAGGAGCGCTGCTGCCAGGGTTTGAGCGCGTCGTCGGCCAGCCAGCGGCGCACGGTGGAGGCGGAGACCGAGCCGGCGATCGCCCGGGCGACGACCTCGCGGGCCAGCTCCGGGCACGACCAGCGCGACAGCGACACCCCGGTCTCGGCCGGCAGCCGGCAGGCCAGGGCCTTGACCTGGGCTGCCTGCAGCGCGGTGAACGACGGCGGCCGTCCGGACCTTTCGCGGTCCCTCAGCCCGCCGAGACCGTGCTCGGCGAACCGGCCCCGCCAGCAGCGGACCGTGTCCAGGTGCAGGCCCGCTTCCCGGGCGATGCGCGCGTTGGAGCGTCCCCGTGCGGCATGCAGCACCACCTGCGCGCGCGTAACCGGTACTCGGTTTTGTGACCGTAGGCCATCTTCTTCAGCCGCTCGCGCTCGGCGGCGCGCGGGGCTATCGGGCGGGCGGTGGCAACGGGCAAGGCAGGCCGATGTGGGGCTTCGCCCTCTACTACGCCGGCAGCGACCGCTACGAGGACTCCCGGCTGCCCACGGGCACCCCCGCAGAAGCACTCGACTGCGCCTGCCAGCTCCACCTCGCCGCCCCCGGCATCTGACCAGACACCGACCGCAACTGTCCTGTCTCATTCAACCTTGCTGCCGGGGGATGCCCTGACCTGCGGAGACACAAAGCCGGGTGCGACAGGCGGAACCTTGCCGTCTCACTTGAAGTTGTCGGCAGAGCGGGAACGGAGGTCTCCCCTTCGCGCGAGGCTTGTGTTGGACTGTCCCGACATAATCCATACACGACAATGGGGTGAATGCGATGCCTCTTGAGGGCGAGTACGAGCCGAGTCCGGCGCAGTGGGTGCGCGAACAGGTCGAGCTGTACGAGAGTTCGGGTGGCACACAGGGCACAACGCTCTGGGACACGGGCCTGCCGGTCGTCATTGTCACGATGCGCGGCGCGAAGAGCGGCAGGATCCGCAAGATTCCGCTGATGCGCGTGGAGCACGAGGGGCGGTACGCGGCGGTGGCCTCGAAGGCCGGCTTCCCGCGCCACCCGGTCTGGTACTTCAACCTCAAGGCCGACCCGCAGGTGGATCTCCAAGACGGCCCCAAACGCCAGGGCATGATGGCCCGTGAGCTCACCGGGGACGAGAAGGCCCAGTGGTGGGAGCGCGCGGTCGCCGCGTATCCGCCGTACGCCGAATACCAGGAGAAGACCAACCGCGTGATCCCAGTCTTCGTACTCGAACCCGAGCACCTGGCCGGGCCGGCGAAGGCCCCGGCGCCGACGAGGAACTGAGCTTCGGACCCCACTCGCTCGGCCCGGCAAGGCGCCGCGCGGCTGAGGACAGGAGCCCGGCGCCGGCCTGGACAGGCTCACCTGACCTTGTTCCCGGAATGCGAACTGAACAAGGTCAGGTGAGACGGAGGCGAGATCTTGTGAGACGGGACAACACCCCTGGCTCCGCCGTCAACTCCCGAAGGACTTCCGGACCGGACCACTAAGGCAACTCCTCGCCCGGGTGGGCCGCTTCAAGCTGAGTCTCGGTCGCGCCGCAGGCGACGGTACGGCGCTGGGCTTCGGCGTCTCCCCGGCGGTGGCAAGCCAAAGCCCTCCGAGAAAAAGGAATCCCGATCCGATCACTACAATTTGAAATGATCACTACACTCACAGTTCAGGGGCCATCTCAACATCCCTGCCCTACAAAAATCCCTGCTCAGAGCAGCATCGCACCACGACACTGAATCCTGAAACGATCACTGCATCCACAGGACAACCACACCGCTTACTCAGTGATCAGCATCGGATTTGTCGCAGTGAAGGGGTGCCACTCCTCTCGGCACCCGGTGTCGGTCCTGCGCCGGGCGTGGTGATGGGCCGGCCGCTTCCGCGCCGCCGGCCCACCGAGCGCCGTCCTACCAGGCCACGTAGGCGAGGTGCACGATTCCCGCGTTCAGGTCGCACCACACGGTGGAGACCTGGCCCGTCTGGACCTTGGGCCCGTCGTGACGGTACTCGTATCCGTTGTCCCACCGCTTGCACGTGACGGCGACGTTGAAAGCGTCGTCCCAGCTGGTGCCGAAACACTGGAGCGAGGCGCCGGCGTGTCCGCCGCTGCCCGTCATGTACTGCGGCGGATTGCACGTCCAGATGTCCTGGGCGGAGGCGGAGGCGGGGGCGGCTGCCAGGAACAGCCCGCCCGTTGTGATGCCGAGCGATGCCGCGACCACTGCGGCACGTCGGTTGATGGACATGCGGAGCTCTCTTTTCCGTGCGCGTCTGAGGAAGAGCGCTCCCAGTGTGGCGCCGGAACGACTGGAACACCTTCGCAATCCGCGCATAGTTCTTTGTCTTCTGGCGCAGCGTGCAGAGGCGGTGCATGAGACGACCGCCTTTGCGGAGCGGCACTTCTGGCGGAGACGGTACGCAGACCGCGGTCCCGTTGCGGACTTCCGGTGCCGGCGCCAATCCTGGAGGACGTCAGGCCCGTCCAGGGAAGGCGAAGAGTTTCTGACTCGGTCTGCTCGTGCCCGTGGCCCTTCTCGCTGTGCCGGGTGGTTGTCCCCGGTGCTCAGGAGTGGGCACGGGCGTGACGCAGCCGGGAGCAGAGCTCGTCGGCCGGATCCGGGGCCGTGGATGCGGCGTCGGCCCTCGGTGAGGAGAACGGACAGAAGAGGGACCGCGTCCGTCACCGTTTCCTACCCACCGACGATCACCGCCCAGCGCGGTTCGCCGGCTTGACGCGACCGACATCATCCGGTCAGCCGGCCTAGGAGCTGGCTGGCCTGGGGGCCGAAGGTGGCGTCCCCGGTGTCCCGCGCCCGCTCCAGGTACCGCACGGCCTGGTCGGTGTCGCCGTCCTCGCCGGCCATCTCCCCGAGCCGGTAGGCGGCCTCGGCGACCAGATCCGGGTTGCTCCTGGTGGAGTCGAGGGTGCGCTGGTAGAACTCACGCGACTGGTCCCGGTCGCCGACCCAGTAGTACAGCTCGCCGAGGTGGGCCAGAGCGAGCTGCCGCTGGAACAAGTCACCGGAGTCGATCACCCACTGGTACCAGCGCTGCGCCTCGGCCACATCCCGGCGGTCCTTGGCGTCGCCGCCCAGCATCATCGCCCCCATCGCGGCCGTACCCCGATCGGCGTTGTCGACCATGTCCAGGTAGCGGCGCCGGGCATCCTCGGTCTCGCCGGACAACGTCGACAGCTGGGCCAGCCGCAGTTTGCACCCGCCGAGGACCGTTTCGCCGTCCTTCCCCAGCCTGGCCGCCACGTCGGCACCGCGCTGCTGGGCCTCCTTGGCCAACGCGAGATTCCCCTGGTCCTGGTACAGACAGCCGAGTTCGTACCAGGCTCTGCCGCGGAAGGAGGAGTCCTCTGTCGCGCCGGCCCGCTGGTAGGCCGCGATCGCCGCGTCAAACTCTCCTCGGTCCGCATGCGCCTTGCCCAGGTAGTAGTGGGCGCGGACCGCCCAGGTGATGTCGTCGGTGTCGGCGATCAGCTCCCAGGCGAGGATGGCCTCGTCGATCCGCCCCGCCCCTTCCAGATCAGTGCCCAGTCTGAAGCAGTACTGCGGATGAACGTCGGCCGCCGGCAGCTCCTGAGCCTCCTCGTGCCGGCCCTGGTGCCGCAACAGCACGCCGAGGTCGACGGCCGCCTTGCTGCGCGCCTCCGGGAACTCCTCGGTGCTGACCCGCTGGTACAGCTCGACCGCCTGGTCGAGGTCACCGTCGAGGTAGAAGCGGCGGGCGGCCTCCAGCACCCCGCTGCCCGGGTGGCGGTCGAGGCGCAGGTTCGACGCCTCCCTGGCGGCCAGTTCGCCGTCCAGATCGTGCTGGATCTGACAGACCTTGATCAGCCGCTCCCACACCTTGTGGGCCAGGGGTGCGCTCTGGTCGCCAAGGTCGGCCAGCACAAGGAGGGCCCGCCGGGTGACGGCCGACTCGTCGGGCAGCTTCCAGAGCACCGACATGCAGCACTCGGAGGCCATCTCCAGCGATCGGTCGTCCCACCGGGCCAGCCGCTCGAACACCGCCCGCATGCCGTCGGCTTCCTCGTCCAGTAGCAGACGCACGGCCAGCGCCGGGGCGCCGAACTCGGGATCGGACTCGGGAATCCGCTCCAGCGCCTCCCGTCCGCCGTCCAGATCGTCCTCATAGGTGATCAGCTTCTCGGCCGCCAGCCAGGCGAGTGGCGGAACCGCCTCGGCGGGCAGGTCGCCGGTCAGCAGTTCCTCGGCCAGTTCGTACCGCTCTTCCGCCGACCAGCTGTCCGCCGGCGAGGAGTTGAACAGCCCGGCCGCGGCGCGGGGCACGAGCGCGCGGTGGCCTGTGTCAAGCACGCCCTGGAAGAAGGACTGGCTGTCACCGCTCCCGTAGGAATCGGCCAGGTTCGCCTCGCCGAGCCGGACGGCGGCCCAGGGCAGCACGGCGGGCGCGGATTCACAGGCTTCGGCGAGCGCGTCCACGACGCGTTCGGTGTTGTCCCACATCGTCAGGTTGGTGGCGGTCAGGTAGGCGGTGTAGCCGACCGCCAGCCTGTCCTTGGACTGCACGGCCCTGTCCTGCCAGTGGGCCGCTCCCGACCCAGGCCGGCCGTCGTCGAGCAGGTCGCCGAGCAGGGCCGCGAACACCCCGGCCAACGGGTGCCGGCCCTGGGCCAGTGCTTCCAGGTCGGCCAGTACGTCCTGGTCGCGGGTCAGGTAGCGGGCGAGCGCGCTGACCGGGCCGACGGTCGTGGTGGTGTCCGGAGGCGCGGCCTCGGCGGCGTCCAGGATGGCCAGAGCCACGGCGGCGCGCGGACCGTGAGTGAAGTCGGCGGTCTCGGCGAGGTCGCCCAGGAGCTGGCGGGCGGCGGTGAGATCACCGTGCCGCAGTTCGATGCCGGCGAGCACAGTGCCGGCCTGGTGCGCGGCGTGACGCCAGTCGCCGGCGGCGACGGCGCGCAGCTCGGCACGGGCGGCGGTCAGGTCCCCGGCGCGGTAGTGGCCGAGACCAGACCGGACCGGGGCCAGCCAGAAGGGCGGCTCCTCCGGGTCGTCCAGCGGGGCCAGCGCGAGATCGACCAGGTCGGGCGCGTCGGCCTCGGGGCTGGCGTAGTCGAGGACTCGGGAGGCGCCCTCGTGGTCGCCCGCCTCGCGCAGCAGCTTGGCCAGTGGCGCGGCGGCCCGCGGCCGGAACCAAGGGTGGCCGGAGTCGACCACGGCCCAGTAGGCGCGGATCGCCGCCAGGAAATGCTGCTCGCCGCACAGCAGCCGACCGAGCTCGACACCGGCTGCCGGAGCCAGGTGCGGATGCTCACTGCGGGCGAGCGCGGCCAGTTGGCCGGGGGCGGAGTCAGCCTCCCAGACCTGCGGATAAGCGACGGATTCGCCGGCCGCGATCCTGGCGAGGTTGGCCCGCAGCGCGGCGAACCCGCGCACGTCGGACCGCCGGCTCAGGTCCTTGGCGCGCTGGTGCGACTCCACCGCGGCGGCGAACTCGCCAAGCTCGAACTGGGCCAGGCCAACGCAGTTCAGCGCCACGCCGCGCAGGTTTAAATGCCGGGCGGCGAGCACCTGGTCGTGGACGGCGTGCGCGGCGGCTAGGGCCGCCCGGCGGTCGCCCTTCCGCAACTGCTCGGCGAACACCGCGAACGCCGCCCGATGCGCTTGGTAGCCGCTGTCCACCCCCGACGAACCGTCCACCACTGCCCCTACCTTCGTGATCCTGGTTGTGTGCTGCGCAGAGCGTAGGCGACAGGTCCGACGGCGGGGTTGCGGCGGCGATCAGAGGTCATTCCCAAACCCCGAAACAGCAGGTCAAGCAGTGGCAGCCCGATAGGTGGGGCTCGTGAAAGCGTTCGTGGATCGGTCATGGGGACCGTTCCACGAAGGGAAGTCATGGAGCGGGTGAGGCACCTGAGAATGAGGTGACAGGCACAGTGGTGCCCTCGGCCGGCGGCTCACGAGGTCTGCTCACCTCCGGTGAACATGTTGATCAGGCCGTGGGGTGCGTCGTCTCCGTAGAACAACTCGTGGACGTAGGTGCCTCGGTGGCGGCCGCAGCGCTGCGGGGGAACATGGCCTGCTCGTATTCGGTGAGCGCGGTCTCGACGTCGTCGGGGTGTGCGGCGAGGGCCTTGCCGAGTTCGGCGGCGTCGTACATGGCCAGGTTGGCGCCCTCGCCGTTCGGGAGCGAGAGGTGGGCGGCGTCGTCCGCGAACCAGTCCCGTGGTCGGGCGAGCATCACGTAGGTGTGCAGGGTGCCGCCCTGCTCCCGGTGAGCCAGGAATCCCTTGCCCGGCGCGAGCGCGAACAGCGACCCGCCGCCGACCGCTTTCGCGCCAGCCGGGTGGTGGGTGTCGGCGTCGAACAGGTAGGTCTCGACGCCCGACATGCCGATGTACTCGGGGGTGGTGTCGGACAGCAGCGGCCGAACTCGGGACCACGCGCCGTCCGCACCGACCAGCAGGCCGGTGGTGGCGGTGGTGCCGTCGGCGAAGGTCACCTGGTGGCGGCCCTCGCCGACGGCACGGGTGCCGCTGACCTTGTGCCCCCACCGGACGGTGTTGGCCGGGAGCGAGTCGAGGAGCATCTGCCGCAGCTCGCCGCGCAGCACCTCGGGGCTGCCGCCCGTTCCGTCGTCGGCCTGGTCGAGCAGAATGCTCCCGGCCCGGTCGAGGACCCGCATCGCCTGGCGGCCCTCCAGGACGAGGCCGCGGAACTCGTCCGTCAGGCCGGCCGCCTGCAAAGCCGACGGTCCGCTGTCCTCGTGGATGTCGAGCATCCCGCCCTGCGTGCGCGCTGTCGCAGAGGCCTCCGCCTCGTAGACGGTGGCCGGGATGCCGTGAACGTGCAGAACGCGGGCGGGCGTGCGGCCGCCGAGTCCGGCACCGATGACTGTGACGTCAGTGGTCATGGTGGTTCCTTGCCGTCGCACGCCTGCCGGATGGACACCTGGCAGGATCTGTTTGAAAGGTTCCAGGCCCCGCCGAAAAACCACCGACAACGGGCAGACAGCCACCGGTATGTGACCGACACCGCGGCTTTCCGTCCGATCACCGCAGTTCAAAGTACTGACCAGCAAGGAAGGCTCAGCGCTTCATCGGCGTCGGTCGGCTCGACGTTCACCATCTACGGCTCCTGTTTGGTGGGGGCCAGCAGGGTGGCGTTCGCTCCAACCGGAAGAGGTCAATCAGGGCATGTGTCAAAAGTAGATCTTGGTCGTGAGATGATCTTCATTCGTGGCGCGTGGAGACCTGACGGACAAACAATGGGCGGCGCTGGAGCCGCTGTTGCCGAGGGTCAAGAAGCCCGGCCGGCCGCCGATTGGACCCGGCCGCAACTGATGGACGGGACGGCACCCGATTCCGGGTCCGCACCGGCGTTCCCTGGCGGGACGTGCCCGCCGAGTACGGGCCGTGGGGTCGGGTGTACGACCTGTTCCGTCGCCGACAGCGGGACGGAATGTGGCACCAGATCTTCATCGCCCTCCAGGCCCGGGCGGATACGAAGGACCTGATCACCTGGGCCATCAACGTCGACTCGACGATCGTACGGGCCCACCAGCACGCCGCTGGGGCACGCAAAGGGGGGCTTCAGAAGGAGCCGCCCGGCGGCTCGCCGCCGAGCCGGACAACCACGGGCTCGGACGCTCGGCTGACCACCAAGTTGCGCTTGGGCGTCGAGCAGGGGCAGAAACCCATGTCCATCGTGATCACCGCCGGGCAGCGTGGAGACTCCCCGCAGTTCGAGGTCGTCCTGGGCCGTATCAGGGTGCCCCGCCTGGGGTCGGGCAGGCCGTGCGCCCGGCCGAGGCGGGTGCACGCGGACAAGGCGTACGCCTTCCGGAAGAACTGCGCTTACCTGCGGCGGCGTGGGATCCGCTGCACCATCCCGGAAAGGGCCGACCAGGCCCGCAACCGCAAAAAGCGCGGCTCGCTCGGCGGCCGTCCGCCGAAGTTCCACCCCGAGGACTACAAGGCTCGGCACGCGGTCGAGTGCGGCATTAATCGGATCAAAAGGCACCGTGCCGTGGCCACGAGGTACGACTGTGAGGATGATCGGGTGCCGTCTCGGGCAGTGGTCTGGCCCGAGGTACGACTGGCCCTGATGCCCTGAGTTTGATCTGCCGACCACCGCTGGGGGCGGCACGTGCTGCCACCGGACCGGTGGGCGTGTCCCGACAGGGGCCTTCGCGACAGGCACCGTACCGTCACAGTCCTGACCGACACACCTGGCCCGGCGTCGGCCACCGGTGTTCCCGAAGCGCTCAGGAGACAGGCAACCGTGCCCAGCATGACCCAGTCCACCCGCCCCCGTCACCACACGCCCGAACCGCTCGAAGATGTCGTGCTCGGCGTGGATACCCACAAGGACATCCACGTGGCTGCAGTGATCACCACAACAACAGGAGCCCTGCTGGACACCCGCAGCTTTCCGACCACCGAGGACGGCTACCGACAGCTTGCCGGCCTGGGCATGCGCCTTCGGCCGCCTGCAGCGGGCCGGCGTGGAGTGCACCGGCTCCTACGGCGCGGCACTGACGCCCTACCTGCACCGCGAGGGAATCGCGGTTACCGAGGTCAACCAACCGGACAAGGCCACCCGGCGGCGACGCGGCAAGACCGACGCGATCGACGCCGCAGCTGCTGCCCAGGCGGTGCTCTCCGGACGTGCCACCGCCACCGCCAAGACCAGCGACGGTCCGGTGGAGGCCATCCGCATGTTCAAAATGGCCAAGGTTTCCGCGACGAAATCCCGTTCGCAGGCGATCAACCAACTCAAGGCCGTCCTGGTCGCCGCCGACCCCACCCTGCGCGAGGCACTGAGTGGCCCGAGCAATCCGAAACTCATCCGGAAGTACTCCGAGCTGGAGGCCGCCGCCGACACTTCCCCGGCAGCGGCTGCCCGCCACACACTTCGGCTGCCGGCCAGGCGCATCCAGCATCTCACCGAGGAGATCAACGACCTCACCACGCGGATTACCAGGGCAATCGCCGACTGCGCACCACGTCTCCTGGACCGCTACGACGTCGGTCCGGACACCGCTGCCGCCCTGCCGATAGCGGCCGGCGACAACCCGGACCGGATGGGCAGCGAGTCATCCTTCGCCGCACTCTGCGGTGTCAGCCCGGTCGAAGCGTCCTCGGGTAAGACCCAGCGACGCACGCTCAACCGAGGCGGCGACCGCCAGGCCAACTCCGCTCTCTACACCATCGTTCTGGCCCGCTTGCGCTGGGATGCCCGTACCCGCGACTACGTGGAGCGTCGTGTTGCCCAGGGCAAGACCCGCCGTGAAGCCATCCGCTGCCTCAAACGCTACGTCGCACCGAGTGCACTGCGGCGTCAGCATGTTGACATCCATAGGGGCATCAAACTCGCGGTCCGCTACGAGGCTACCGTCCTCGTAGCGGCCATCAATGAATGGCTGTGACCAGCGTCGTTGAGAGTGATCCAGTAGCGGCGCTTGACCCCGCTTTCGGTGCTGCGCACATCTTCGAGGACGCCGCCGTTGCTTTCGATGGTGCGCGCCGAGCCGACGTTGCCGTCGTCACAGGTGAGGAGGACCCGGTCCAGACCGAGCGCCGGCGCCTTGAGTAGAACCTCTCCCAGCGCCCACGAGGCCAGTCCGCGTCTCCTGGCGGAAGGCCGAACGCTGTAGCCGATGTGTCCGCCGCCTTCCAACAGAAAGGCGTTCAGATAGTGCCGAAGGTCGATGGCCCCGAGGTACGTCTCGCCGTCGACAATCCACCAGTGGGTAGCGTGGACGCGTCCTTCCCCGACAGGCAGCGACCGGTCCGATTGCTGTCGCAGTCGCTCGACCCATGAGGCGAACCCTTCCGGGCTGTCGAGCTCATCGTCACCAACCAGACGCAGGCCAGCCCCGTCCTGGTGAGCACCAGGCTGCCACTCGTCACGCGCCGTGAGCCACGAGGAATGCAGCCGTCCCGTGGGAGCGATCAGTTCAGCCATGCGAGGGACCATAACACCCGCGCCCCCTGTGTGATCAGGCGCTTTCTGCCAGATCGGGAGCCTGGCCCGTCGGATGGAGTGCAGGTGAGCCAGATCGAGGCGAGATCGCCTCATTTCGCCGCGATTGCTCAGCCACTGCCTTGATTCACTTTCGGCACACGCCCTGGCCTCAGCGTTTCGCTTCGTATGACTGGGCTGGTCTGCCGGTGCTGGGCCTTGGGTTTGGGGGCTCTTTTGCCGAGCCGGCATGCGTGGGGCCCGACGCGCGGGCCGGGTGCTCCAGGTTTCCTTGTCGTGGGCGGGCAGGGACGGCGTTGTTGTCAGGTAGCCGGGCGAGGCAGGGCCGCCAGGCGGGTGAATGCGCTGGTCAGCTCGTGTCGCCAGGACCAGGTCGCAGAGATGTGTAAGCGGAGGCGGTGTCCGCCGCGGGTGATGCGGGCGGCGGCGTGCAGGAGCCTGTAGCGGATCTTCTTCGGCTCGGCGGTGGCCAGTTCACCTTCCAGTAGCAGGGTGCGGGCCCAGGCGAGCAGGTCGATGGCGGCGAGTGCGAGTTCGAGCCATGCGGCGTTGACGTGGAAGTGGCGGGAGAGAAAGCGGCCGAAGCCGGTGGTCTTCTCGCTGCGGCTGCAGTCTTCGACGCCGCCCGCACTATCGCGTTCCCGCCCAAGATCCGGATGCCTCTCAAGCGAAACGGCGAGGCTAAGCCCGGGTGATCTCGAGCGGGGAGGATGCCGGAACCAGCAGGACTCCGGTCGGCAGCTCCCAGCGTGCCTTCGGGTCCGCGGCCCACTGCGGCTCGTCCGGCCAGCCGCTCAGGTAACGCCGTCCGAAATAGACCATCGCGAGCGGCTGTCCCAGATGGACCGGCGGATCCTCCTCCATGAAGGACAGATCGTCATCGTCGTCGGCGGTGACGAACCCGAGGTACGTGCCCGCGTACTCGGTGACGATGCCGATCAGCTTCGCCAGGGCGTCGGTGTTGCCCCGGTACTCGTCGAAGTCCTCGGCGAGCCGGCGCTCGTCGACGGCGATCTGCACCATCCAGCTGTCACCGAGGTGGACCGAGGCCGCGAACTCCGACGGGTCCGGCAGCCACACCTCCAGCGACGGCCCGAAGTCGGCGGGCGCCGTCCGGAAGCCCTGCCCCTCCAGGACCTCGGCGAGACACTGCTGGTCGGCTGGGGCAGACGCGTCACGATCGTCGTCGTAGGGCAGACCGATGAACCAGATCTTGTCGTCCATGGTGGCAGCCTGTCATGTGCGGGGCGGACATCAGCAGGGCGCCCCGTTGACCGTGCTGTGCTTCTTGTCGATGTCCCACAGCTCCTGCGGAACTTCGAAGAGCGCTGATTTGAAGACGAGTTCGAGTTCCGCATCCGGCCACCGAGTGCCACCGCGAGCGCGATATCGACAGAGACCAGGTCCAGGTACTCGATGGTGTGCTCAATCTTCCGCACAGCCGGAGTGCGTTCGCGGATCCGGTCCTGGACCTGCTCGGAGTTGTCGAACTGAGCCCAGTTGACCAGCAATCCTGGCGGTGTCATCCCGCATGGCCTCCCGCGCGACGGCCGGCCGCCGCACAGCAGCTCGGCGGTGGCCTGCCGGACGACGTTCTCGCCCCGGGTCAGCTCGCCCACAACCCGCAGCTTGTCCTGCGGGCTGACCTGGTCGGTCACCGTAGGCCGCCGCAGCAGATTGGCACTGTCCTGGGTCCAACGACGCTGACCGGTGCGCTGGTTGAACGGACGGTTATCAATCGCCGCTCGCCGTTCCTCCTCGTCGTTGATCGGGGCCAGGATCCGGTGAACCCCGAAGGCACGGCGCCCTTGCGCTTATCGATCGGCCACCTGGAGGCGGTCCACCGTCAGTCCTTCACCGTGGACGGGGCCACTTCAATGTCTTCGGCAAACAGCGCGAACGACTCCTCGACCGTGAACAGGTCCTCGGTGCCGTTCGGCATCGCCCCGCCCACTGGCCGCATCGGCTCGATCTCCAGGGTCTTGTCTCCCAGCGTGAACTGGGTCCGCGTGATCTGCGCGACCAACTGCCGGGCCGCGGCAACGATCTGCTCGTAACGCTCCCGCGTGACATTCCCGACGCGCTCCGGCACGGTTCCCACCACCTCACCCCGGCCGGGCACCGCCGCCGGGCAGCGGTCGGATAACCGGACGGCCCGACCAAGCTCGGGCCACCGTGATGCGAACGCGTCATTACGCGCAGGGCGCGAACCTGGGGCGGTCGAAGCACCCGGGCGCGAGCCCGCGAAACCCGTGCGCAACGGGAGTGTCTTGTGGTGCTGAAGTGGCGTTCCGCTACGGCGTTTCCCCAACGACGTCGACGAATTCGTCTGTCGTGAGGATGGCGTGGGCGTACAGGGGCGCGTTCAGCTCGAATGTCGCTGTCATCTCCTCCCAACTGAAGGAGGCGATGGCGTCGCGGATGAGGGTCACGTGGTAGCCCAGCTCCTGACCGAAGCGTGCGGTGGTGTCCACACAAGTGTTTGCCCGCATACCGATCAGCACGATCTTGCGGATGTGGTGCTGCTTGAGCATGAAGTCGAGGTCGGTGTTCGCGAAGCCGCTCGAAGCCCAGTGCTGGCGCATGACCAGTTCGTCCTCGCGAGGGTGGAGGTCGGGGTGCCACTCGGCCCCCCAGCTGCCCTCGGCGAAGGTCTGCTGGGTCACGATGCGCTGCTGGGTCGGGGACAAGTGGTCCCACGTGATGTAGTCGTTCGGCGTCGTCTGGTGGTGGGGCACGATGAAGACGCGAAACCCCTGGCTGCGGGCCGTGGCGAGCATGGTGCGCATGTGGTCGAGCAGGCCGACGCCTTCCGCCACTTCCTTCGCCCGGGGCCACAGCTTGCCGCCCTCGGAGAGGAAGTCGTTGTACGGGTCGACGAGCAGAAGAGCGGTTTCATCCGGGGAATACGGCGCTACAGAAGTCATGAACAGTTCCCATCTGGTCAGCGAACGGATCGATCGCTGCCGGGATGCGAGACGGAGTGGACGCCCAGGGCAGCCCCCAGCTCCTCTGGTGCAGGCCGCCGACTCGACCTTCAGTCTGTCACTCGTCCGGCCGAACGGCATCCGCGCCGGTGGACCCGGACGCGCCGGGATGGGTCCACCTGGACGGCAGGCGCATCCTCTCGTGTCTGGCACTCGCCGACCGGTGCGACGGGCGAGAGGTGACAACCATCAAGGGGGTGGGCGATGACGTGCGAGCCCGCCAGGTCTCCGAAGCGCTGCCCGAGGCGGAGGCGGACAGCCGATTATCTCGCCGGCGGCACCACGCAGCTCGACTTGATGAAGGACGGCGTGTGGCTGACGCGGTAGCCCTTCATCGCAGCCTCGGTGCCCAGCACGATGAGCATGTGGGACTTGCCGGTGCCGGAGTCGCCGACGGCCTGGATACGCCGTCGCCGCTGCGCAAGGAACACGCCTGGCCGCCCCTCCTCGCCCCGCACCTTCCTCTCCAGAATCCCCGTCCCACAGCGTCCTGGCGAGCCCGCCGACCGCACCCCCGGCTGCGCGCCCCGCGGAGGCGGCCGTCGCCCTGGCCGCATTCCTTCCCCCGACTGCCCGCCCCGACGGAGCGCACGCAGGCCGAGACCGCGGTGGCCCCCTGGCCGACACCGCCGAACACTTCACCCACGAGCTCGTCTCAGCCACCGAACCGGGGCTGATTCGCGACCCGGCCTGCGACCCCGCCGCCGCTTGGATCCTGCTGCCGGCCGGCGCCGTCGACCGCGCTCCACGAGACCGACCAGCCACGCCCGGACGCCGCGACCCCACGCCGCACCCGCGACCGGGCGGTGCTGCGCGCCTCGCCGGCATCCACATCGAAGACGCCGGCGTCCATGGCCGCCCCTAAGGCAAGCCCATCTTGGTTCCTGCTTCTGAACCTCGAAGAGGCAGGTCAAACCACAGCTGCCCAAAGAGCGAGGCTGCTCGCAGAGCGGTCGCCGTGACCATTCCGCGAGATGCCGGCCAAGACGGGCCACGCACTGCGGCCAAGCTCAGGCGGGCAGCTTCGTGTCGATGACGAAGCTGATCTCGATGACCTGGCCGGGGAAGGTCAGTTCGGTGACGCCGAAGACCGTGCTGGCCGGACGGTGGTGGCCGAAGTACGCCAGGTTGCCCTCTGCCGTCGCCGCGGCATTCTGGCGCAGGTTCACCACGTACAAGGTCTGCGAGACGACCTGGTTCCGGGTGACGCCGTAGTGGTCCAGGACCTTGTCCAGGTTGACGTAGGTCTGCTTGAGCTGGGCGTCGAAATCGTCCGCGTAGAGGAACTCGCCCGCCTCGTCGAGTGAGAGCTGTCCGGAGACGTGGATCAGATCCCCGGACTTGATCGCCTGCGAGTAGCCGAAGTCACTCTCGGCAGGCACATTGTGGTTGAAGACATCGATGGTGGCCAACGGTGCTCGCCCTTCTGTCTACTATCTCTTGTGGTTACTCAGGAACTGTAAGAGAGTGATAGCGGACCTGGAAGAACGCACTTTTCGGTGACTGAGGAACCTCATGGTGACCAAGCAGCTACTCAGGGGCCTGCCCGAGAATGCAGACCTCAGGCGCGCGGACTCCCTGGCGCGGGAGATCTTCTCGGACGTCGCCAACAAATGGGCGCTCCTGATCATCGAGGCGCTCGGCGAGCGCACCCTGCGCTTCAGCGAGCTGCGGAACGAGATCGAGGGCATCAGCCACAAGATGCTCACCCAGAACCTGCGCATGCTGGAGCGCAACGGCCTGGTCAACCGGACGGTGCACCCCACCGTGCCGCCACGGGTCGAGTACACCCTCACCGAACCGGGCCGCGCACTGCGCACCACGGTCGACGCCATATGCGGCTGGACCCACCAATACCTCGGTCACATCGAGGACGCACGCCGTCGCTTCGGCGACTGACGGCCGCACAGCGCCACGCCCCCGTTGTGCGGCGGCGCTGGGCACGCCGGTCGACCGATCGGAGCCGACCCCTCCTGCTGCAGACCGCCGTGCCGGGACAGCGACCAGGGGGCATGCAGTGGGGGTTCGCCCACCCTCGTGGTGGATCAGGACAGGTCGAGCGGGCCGTGAGCCACGTACCGCGGACCACCACTGTCAGTGAGGACGAGCGGCCCGGCCGGCTCGTACCCTGTTTCCCGTGCCGTCCTCCCGCCTGCGCCGAGTCGCCGTCCTCGTACTCGAGGGTGCGAAGCCGCTCGATGTCGGCATCCCCGCACAGGTGTTCACGACCCGTGCCAGCATGCCGTACGAGGTGCGGGTGTGCGGCGCGGCGCCCGGGCTCGTGACCGGCGGCGACGGCCTGGCCTACCACGTCACCCACGGTCTCGACGCGCTTGGGTGGGCCGACATTGTCTTCGTCCCCGGCTATCGGTTCCCGGACCGCGACGACCCGCCACGGGCCGTCGTCGACGCGCTGATCGCCGCACACGACCGAGGTGCACGGCTTGCCGCCATCTCGACGGGCGCCTTCGCGCTCGCCGCCACGGGCCGGCTCGACGGCAAGCGCGCCACGACGCACTGGCACTACACGCGGGCGCTTGCACAGAAGCATCCGCTCATCCGGGTCGACGAAAACGTCCTGTTCGTCGACGAGGGCAGCGTGCTGACATCGGCCGGCGCCGCCTCGGGCATCGACCTGTGCCTGCACATCCTGCGCGGCGACCTCGGGGTGGCCGCGTCGAACCACGCGGCCCGGCGCCTGGTCGCGGCCCCCTACCGCAGCGGCGGCCAGGCGCAGTACGTGCCGCGCAGCGTGCCCGAGCCGCTCGGTGAACGGTTCGCCGCCACCCGCGAATGGGCCCTGCACCGGCTCGACGAACCCCTCAGCCTCGAATCCCTCGCCCAGCATGCGGCGGTCTCACCGCGCACGTTCTCGCGGCGCTTCGTCGAGGACACCGGGTACACGCCGATGCAGTGGGTCATGCGCGCCCGCATCGACCTGGCCCGTGAACTGCTCGAGCGTTCAAAACGCAGTGTCGAGCAGATCGCGAACGACGTCGGTCTCGGCACCGGCGCAAATCTGCGGATGCACTTCCAGCACATCCTCGGCACCACCCCCAGCGAGTATCGACGTACCTTCACCCGGGGCGAGTAGCCCGCCGCCCGGCGTCTGGCGCGATCCTTGCGAACCATGGCGCTCACGCCACGGCCATGGCCGGATCACGCACGCGAAACTGGTGACGAACCGAAGGGACACCACGACACATGACTCGCATCGCCATCAACGGATTCGGCCGCATCGGACGCAACGTGCTGCGCGCCCTGCTGGAACGCGGCAGCGACTTGGAGATCGTCGCCGTCAACGACCTCACCGAGCCCGTCACCCTCGCCCGGCTCCTCGCCTACGACACCACAGCCGGACGGCTCGGCCGTCCGGTGACCGCCGACGGGGACGCCCTTGTCGTCGACGGCCGACGCATCACGGTGCTCGCCGAGCGGGAGCCGGCGCGGCTGCCGTGGGGCGAGCTCGGCGTCGACATCGTGCTGGAGGCGACAGGCCGCTTCACCTCCGCCAAGGCCGCCCGCGCCCACCTGGACGCGGGAGCGAAGAAGGTGCTGGTCAGCGCGCCGTCGGACGGCGCCGACGTGACGCTCGCGTACGGGGTCAACACCGACGCGTACGACCCGGACGTGCACACGATCGTCTCGAACGCCTCGTGCACGACCAACGCGCTTGCGCCGCTGGCCGCGGTGCTCGACGAACTCGCCGACATCGAGCACGGCTTCATGACCACGGTGCACGCCTACACGCAGGAGCAGAACCTGCAGGACGGTCCGCACCGCGACGCCCGCCGCGCCCGTGCCGCCGCCGTCAACATCGTGCCGACCACGACGGGCGCCGCCAAGGCGATCGGCCTCGTGCTGCCGAACCTCGACGGCAAGCTGTCGGGCGATTCGATCCGCGTGCCGGTTCCGGTCGGCTCGATCGTCGAACTCAACAGCACCGTGGCCCGCGACGTGACCCGCGACGACGTGCTGGCCGCGTACCGCGCCGCCGCACAGGGCCCGCTCGCCGGCGTCCTCGAGTACTCCGACGACCCGCTCGTATCGTCCGATATCGTCGGCAACCCGGCCTCGGCGATCTTCGATGCGGCCCTCACCCGCGTCGACGGCCGCCACGTCAAGGTGGTCGCCTGGTACGACAACGAATGGGGTTTCTCCAACCGCGTGATCGACACCCTGGAACTCCTCGCCACACGCTGACCGGATCGAGTGACTTCTCGACCGGAGCGGTGCCGGTGGGAGTGTCCGCAGGGAAGTAGAGCCGGGTGACCGTAGGGCCAGCCCTTCACCCGCGCCGCGGAGGCGATTGATCGGGTGTGCGTTGAAGACGAGCCGGTAGTTCGTCACGTGCAGTCGCCCGCCGATCGCCTCCATGCCTTGCATGCGGATCGTCCGCATCAACTGGTCGTGGGGGTAGCGTTTCAGCCCGGCTGCGGCCACCCTCACGACGGTATGCGCGTTCTTGGTGACGTGCGGCAATCTCGCCAGGTAGAAGGCCGTTCGAGCTCAATGCCATGGCCCCCACCCCTGGTCAGCGCGGCACGGCGCATGGGGCACCAGTCCGGCCCTCGGCCCTTGTCCTGCCCTGGAACCGGGATCCAAAACAGCTACGAGGATGCCCGGCTCTTGGGGACGGGCATGATCAGCATCGGCCGACAGGGGGTGCTGTCCAGCGTTCTTGCCGGTCTTGATGGTCCGCTTCTTCGCGATCTCGGGGACGGGGACGCCGCGGTCCTTCAGCGCGGGCCAGCAGGAGGGAGTCGTCGTCGATGGCCTTCGGCCGTCCGCCGTGGTTGCCCTTCGCAGACGGTGAGTGACACGGCGACGGTGCCCATGCGTTGAGCCGGTTCTCCGGAACGTTTCCCGCAGAAAACCTGGCTGCTCAGCGAGCGGCGTTCTCCCGACCGGGATCCGTACGCCCCGCCCTAGCGCCACGGCTCGTCGGGTTTCGGGAGCGGGCCGTTGTTCGGTGTGGATCCACCCAGGTCGTAGTGTTTGACCGAACTGGACCCCGACACGCTGAACTCCTGGGCGAGACCTGTCGTGTGCAGCCGCGACGGCTGTCCGTCCGGGATGTGGATCTTGCCGATGTCCACGCCCTTGCCCTTGTCCCAGTTGTAGCGGTCCCAGGCGTTGGTCTGGTAGTCGAGGCCGACCTTGGGCTTGCCGCTGGCGTCCGGCTCCACTGTGACCACGCCAGTCACGTTCGAGCCGGTGGATCCGACGGCGAAGAACCAGTTGGGGTTCTTCTCCCGGTCGAAGGTGTAGCCCCTGTTCCCGGTCTGCACCGGGATGGCGACCGGCCTGCCGCCGTTCCTCCAGAACTCCGCGAGCGCCTTCTTGCGCCACTCGTTCTGGTTGTCCCTGATCTGTTTTTCGATGTGGGCCTGGAACCCTTTGTCGTCGGACAGCATCTTGTCGACAGGCAGGAACATGGGGCTGCCGGAGTTGCTGAGGTAGTGCGCCATGTGGCGGCCCGCGTCGGTCATGCCCAACGCGTCGGCCCTCTCGGCCAGCAGCTGCATCTTCGCCCCGGTCATCACCTCCGTCATGCCGGGAGTCTCCGCACCGTGCGGACCCGAACCGGCGTCCGGGGAGAGTCGCTTGATCGTGGTTTCCAGCAGACCCGCCGCCAGCAGGTCCTTCTTGTGCTCCTTCCACAGCTGAGCACGCGCCTCCGGACTCAGCGACTGCCACAGGCGACCCAGTTCGGCGCGCTGCCTCGGGTTCGCGTCGCCGCCGAGCGCGGCCAGCTTCACGGCTCGCGGCAACTGGTCCTCGTCCAGCGAGGTGTACTTGGCGTGGCCGGGGTTCAAGGGTTCGCCACCGTGGCTGTTCTTCAGGGCGCGAGAGACGGCGGCGTCGATCTCCGAGGCGTGGGCGACCAGCCCGGTGAGGGTGTCCGCGTACCACTGCTCCAGGTCCTTGCTCCGCTGCGAATAGAGCGGGAATTTCTTGGAGCACAGCGCGCGCACGGTCACCGTGCCGTTGCCGTTGTCCGACACGGACATGCCGGGGTCCACTTTGCCGCCCTTGCGCGCCTCCTCGTCGAGCTGCTTCGCCCGCTTCTGGACCGCCGACAGCTCGGTGTGGGCGTCCTGGAGCACGTTGTGGATGGACTCGGCCTCCAGGTGCAGATCGCCGAACTCCTTTGCCGTGCTGCGTACGAACTCCCGGGTGACGGTGGCGTTCACCCCCTCCCACCGTGCCGCCTCGGATTTCGCCACCAGTCCCCTGGAGACCTCGGTCTTGAGCTTCGCCAGGTTGCCGACCATGGTCTTCCAGTCGGTGACCGCGGTGCCCAGCTTGCCGAGGTCCATCGTGAGGAGGTTGGTGTATGTGAAGGTCGCCACCCTCGCTCGCCCCCCGTCTGTTTCACGTACTTGCTATTTGACGTACTTGCTACTTCACGTACTGGGAGATCTCCGAGACCGAGACCGCTGCGCCGTCGCGATGGCGCAGCGATGCCGCGAGGTACTCGTCGTCCTTCGTATGTGCCTTCTTCGAGTAGTCCAGGTGGTTCGAGATGTGGGCACACATTTGGAGGACCGTCTTGACCTGCGTGTCCCAGACCGAGACCGTGGTCGAGAGCTCGTTCCCCATGGTCATGTTCTGCGCGGACAGCTCCCTGGCGGCCTGCAGAGTGGAACCCGACCCGCTCTTGTCCATGCCGGCGCCCTCGATGTCGGCCTTCTTCCGCAGCACATCGTGCAGCTCGTACGCCTCGTGGCCGACGGCTCCCAGGTCGTCCTGATGGACGACCAGGTCGTGGTTGGCTCCGCCACCCGGGCCGGGGCCGGGCAGGGCCTGGTTGAGCCGCATCCCGGCCGACTGCCGCTCCTTGGCCGCGGAGACAAGCTCCGCCCACTCCTGGTCGAACGTCACCTTCACCACCATCCCCCGGATATCGCTTTCGGTGGTCTGATGTGCATCCTGCCTCGAAGTGGCGCGAAAGTCCTTTGCATGGAGTGCCAACTCCTTGACTGTGAGCGCAACGTCGGCTCGGCCCGCAAAGGGAGGCGAACACACAGGTCCGAGCCCCGTGGCTTTCCGGATACCGCAGGCTCAGCCCGCGCTACGAGCGTCATCCCCGCAACTACCTGGCCCCTCTCGGACTCGCCGCAGCCATGTGCTGCTACAAACGCCTCGTCCGCCTCACCACACAGGACAGGGTCTTGGTAGTGGCAACGTGTCTCCGGCATGCCCCTTTCGGCCACCTCGCGCACCCTGAGCCTCGGTCCACCGGTCGGACGTCCAGCATTCCCGATGTGTCAATGACCTGACGGATCGCCCGGCCCGAGGCCAGCTCCTCCATCGCCGTGCTGATGCCGGTCAGCGGCAGGATGCCGGTGTGCATCCGCTCCACCGGCATCTGGCCCGCCCGCCACAGGTCCAGGAACCGGGGAATGTCGCGGCACGGTACCGCGTCGCCCATGTACTAGCCCGGCAGGGACTTTGCCTCGCCCGCGAACGTCAGCGCCGGGACCTGCAGACCCGGTCGAGGGCGGGCAGGCCCACCGAGACGGCCGTGCCGCCCCGGGCCACGGCCGTCAGGCATACGGCCATCACCTTCGGGCTGCCCACTGCCTCGACCGCCAGCTCGGCACCACCGGAAGTGAGGTCATGAATCGCCTCGACCGCCTCGCCGGGGGTGTACGCGTGGGTCGCGCCCAGCTGGAGGGCCCGCTCGCGCTTCTCCGGTACCGGGTCGACCGCGATGACCGGGTACGCGCCTGCCGCGCGGGCACCCAGCACCGCGGCCAGGCCCACGCCGCCCAGGCCGTGGGCCACCGTCGACTGGCCGGGGCGCAGGGACGCCGTGTTGATGACGGCTCCGTCGCCGGTCAGGACCGCGCAGCCGAACGTCGACGCCACCGTGAACGGGATGTCCTGCGGTATCGGCACCACCGGCTCCTGGGCCAGCACCGCGCGTTCGGAGAACGCGGAGACACACAACTGGTGGTGGACCGGGTTGCCGGAGGTGTCGGTCAGCAGGGACGGGCCGTGCAGCAGCGCTCCCGATCCGTTCGCCGCGGCGGCCTGTGCACACAGGGCGGGCCGGCCGGCCGCGCAGTCGGCTCAGAAGCCGCTGCTGGGCACGTAGAACAGGGCCACGTGGTCACCGGGACGGACCCGGGCGACGCCCGGTCCGGTCTCCTGCACGACACCCACCGCCTCGTGCCCCAGCGTCCTGGAAGACCTCGCACTGCCCGGCCTGTTCGGGCCCTGGTGCTGCCTCTGGCAGGGTGGTGCGCCGACATCTTGCGTTCCCAGGCCGATGCCCTGCCGGCCTGCGACTTCATGGACCTTGAGGACGCGGGCTGCTTGGCGCGGTTCCTGATCCGGGACCGGGATGGGAAGTTCCCCGCCCTTTTCGATGCCGTCTTTACCGATGCGGGGATTTACTTTGTTCTCAGCGATGTTCGGATCCCGAGAATGAACTCGGCCATGGAGCGGTGGGTGCAGACTTGCCGACGCGAACTGCTGGACCGGACTCTGATCTGGAACCAGCGGCACGACGCGATCGCCTCCGCGGCATCCTCCACGAGTACCGACATGCCGCATTACGCGGACGGATGAGAGCGGATGAGATTTTCGGCAAGCACAGCCGTTACCCCCACTCACTTGGCACACTATCTATTCTTGCGAATCCCGCGGGGGGGGGCTGTCGCGGCGGGTGGCAGGTGCCGTGCGCGAACGGAGAGCACGGCACGATCAGCCCATGAGAGCTGCGGCCACTGTACCTGCCGGCGCCCCACAGCGACCTCATGGTAGAGCAGTCACAGACCCACGATCACTGATCATGCCCATAGTTGGGCGATCACAAAGCCCAGGTCAACCACCGTACGGCAATAAAGACACCTTTCAGGGCTATTCGTGGGTGGATTGAGGTGCGGTGGTGGTAGCTGTCTGGTCTCCTGTCGCGGGCCGCAGCCGTGCAACTCGCGCCGACTGTAGGCTGATTGACGCAGACGCGTCATAGTGAATTCGTCGCATATTCGAGGGGTGCGGGGATGAGGGCATTGGGGTCGCTGGGCGCGGACGACCCGGCCGAGGTGGGGGCGTACCGGTTGCTGGGGGTGCTCGGGCACGGCGGTATGGGGCGGGTGTATTTGGGGCGGAGCCAGGGTGGGCGGCTCGTTGCCGTGAAGGTGGTGCACCGGCATCTGGCGGCGGATGAGCGGTTCCGGGCGCGATTCGCGAGCGAGGTGGCGGCGGCGCGGCTGGTGAGCGGGGAACAGAACCACAACCGCACCGCCCCCGTGCTCACCGCCGATCCGGAGGCCGAGGTGCCGTGGGTGGCGACCGGCTACGTGGCGGGCAGCGACCTGGCGCACATGGTGGAGGAGCATGGCCCACTGCCCGAGCGCACCGTACGTGCGCTGGGTATCGGGCTGGCCGAGGCGCTGGGCGCCGTACATGCACAAGGGCTGGTGCATCGGGATGTCAAGCCGTCCAATGTGCTGCTCGCGCTCGACGGCCCGCACTTGATCGACTTCGGCATCGCCCGCGCCGCCGAGGCGGCCACCCGGCTCACCTCGACCGGCGTGGCTGTCGGCTCGCCTGGCTTCATGGCTCCCGAGCAGGTCACCGGCGAGGCAGCCGTCGGCCCTGCCACGGACGTTTTCTCACTCGGAACCGTGCTCGCCTACGCGGCCAGCGGCCAGCAGCCATTTCCTGGTGAGAGTGCCGCCCAACTCCTCTACCGGGTCGCTCACGCCGAGCCGCGGCTTGACGGTGTTGCACCGGATGCCGTGAAGGAGCTGGTCTCCGCCTGTCTCGCCAAGGATCCTGCCGCCCGTCCGACACTGCCGGAAGTCGTGCGGGCCTTGGCCGGCGAGCAGGATGCGGGCGCATCACTGGATTCCTCCCGCTGGCTGCCCACGGCTGTCGCCGACGACATCGGTCGCCGGGCTGTCGAACTGCTCCAGCTGGAGTCCGGACCGGCGGACCCCGGGCTGCCCGCGCGGCCCCACTCGCCCACCCTCGTGGACTCCGCACCGGCCTCCGGCCCGAACGCCGCGACAGTGACGGTGACCGCCCAGCCGAAGCCGGAGACCACGGCCAAGCCTGAGTTGGCGAACAAGCCGGAACCCCCGGATGCCCAGGCGAAGAAGCAAGGCCCGTGGCTGGCCGTGGGAGCCTCTGCGCTGCTCGCTGTATTGATCTTCGGTGTCTGGAACGCCTTCCAGGACGACGACAAAACCGCTGCCCTCCCCAACAGCTTCGTCGGCCATTGGAGCGACTCGGCGAACGGCTACGGCAACCAGCTCGAGCTCAACGCGGGCCGAGTCGGCGAAGAGGTGGGTAGGCTCACCGCCGATGTCGACGCCTGCCGCCGCTCATCGAGGCGCGTATGGGCGCTACTGCCGGCAGCGCGGATGCGAAGGCCCGCGCGGTGGTCACGACGGCGTTCGCCTTTCTGGATGCCGCATCGATGACGTGGGTCGACAACGACGGCAAGGGCGACATCATGGACCTGTACGACGAGTGCCTGGCTGCCGTGCGTGGCTGACCCGCGGCGACCAGCCGGCCCCAAAACTGTGGGCCGACAGCGCCGAATTCATCGGCCTGACCCACATCACCAGTAACGCTGAGACCGGTCAGGACCACCCCGAAACCGTTTCCGGTCACAGTTGGCCGCGCGCCCGTACGCGCTGCTGCGCGACGCGATGCGACTGAGCGCTTCAGTTGACGGGTTTCGCCGGACAGTGCGCTCAGCACGTGTCCGGGCGCCCCGCCGGCAACTCGTTGGCATCACATAATCCTGAACGCGTCATTCACGCTCCAGGCAGGATGTCTCTGTGCATCACATCCTGTGCGGGCTCGCCGCCAACCCCGCCTTGTCGTCCGAGCTGGTCGACCGGCTGATATCCATCGCGGACGACGACATCGCCGCGGGCCTCGCCTGTCGCGCGGACCTCAGCCGTGCACAGGCGGTCGCGCTGGCCGAGCGCGTCGACGAGAGCGCGGTGCGGCTCGCGTACGAGGGTCGGCTGACCGCCGCCGACATCGATCCCGCTGTCTGGCCGGATGCCGCCCTCGCCCTGCTCGACCAGGGTGTCGGCCGCCCGGAGTGGGCGCGTCGCCTTGCGGCGGATCCGGTCCGTGAGCGTCGGGAGCAGCTGGCGGCCTGCCGCGGCCTCCCGTCCGACGTGGTGGACACGCTCGCGGCGGACCCGGACGTACGTGTCGTCGCCGAGCTTGCGTTGTGGACCACCCCAGATGTGGCCGCGAGACTCGCGGCGCATCCGCACGCCGAGGTCCGCCGCGCGGTGGCGAGCAACGAGGCGACACCCCCGGCCGCACTGGTAGCGTTGGTGACCGGGGAGGGGCTGCCTGCGGCGCGACACTGTCTGGTCTGTGACCGCGAGGAGACCCCCTTCATCCACGATCCGCAGTGTCTACGGCCCGACTGCGATCTGCTGCCGGGCGCCTCCTGCGACGGCTCCCACGAGTCCACCGTCCACGCTATGCGGGAGGCTGCACTCCGTAACCCTGCCACCCCCGTCGAAGCCGTCGTCGGCTTCGTGGATTATCCGTCGATGCAGTTGCGCTGGGCGCTCGCCGCCCGTCAGGACCTGCCCCAGCAGGCCTGCGCACGGCTCGCTTCGGACCCCACTCCCGGTGTCCGCGCCGACGTTGCCGAAAATCCCGCGATCGACGATGCCCTGATCCGTGCGCTGGCCGGCGACCGTGACCCCGACGTGCGCCGCAGGCTCGCACACCATCCCCGCGTACCGCTCGACGTGCTCACCCACCTGGCCCGAACTACCAAGATCGGCGCCACCCTTCTGCCCCGTATTGCCGCCTCCTCTCCCACCGAGGTCGAAGAGCTGGCCACGTCGCCGGACCCGGCCACCCGAATGCTCGTGGCCCAACGACGCGATTTGCCGCCCGAGATACGCGACCGGCTGGCCGACGACCCCGACGCGAAGGTGGTCAAGGCCCTCGCTCCGCACCCGGGCCTCACCGAAGCGCAGTTGCGCACCATGGTCGACCGACACGGTGTCCGTGTCCTGGCCAAGGTGGCGGCCAACCCAGACGCGCCCCCGGCGCTGCTGGAGGACCTGCTTCGGCACGAACCAGCGGCGCAGAAGGTGTTCCGTGAGGTTGCCCGACATCGCGGGGCGACGGCCTCGGCGCTGCTCGCCTGCCTGACGGACAAGCGGGCGAGACCCGTAGCCGCCGGCCACCCAGCACTTCCGCCACCGGTCATCGCAGAGCTGCTCGCCGACACGGACTGGCAGGTAGCGGAAGCAGCAGCAGCCAACCCGTCCCTGCCGCTCGCCGTGATATCGGATCTGGTTGGCCGGCAGTGAGCGCACCGCCCGCCAAGTCGACACGGACACCTGCCGTTCGATCGTCTTGATTCTGTTGAACCAACGCTCGGTCGGCAACGGGTAACGCGGCAATGTGCCGTCAGTATCGGCTGTGGGCTCGCGTGGCAGGACACTCGCACCAAGGACACCTGCCGGGCGAGCCGCAGGGCGGGCCGCGCCCTGCCGCGTCGACCACCAAGTAGTCGTCCCACCCTCGTGACCCGGCGCGAACGGCCGGACCCCTCCCACCGTCTGCCCGGCCCATAATCGCCTTTCGTGCCCTGCCGAACGGGGGCTAGTGTTCGTGCAGCGAGTGACTCACGAGGAGCGAAGACATGGTCGGTCGTCCGAGCACGCGTTGACGTTTGAGGCCGTCAGCGGCCTGTCATCGCGTGCTGCCCTTAATGCGCGGCACAGCGAGCCTTCCTTTCCCGCTGCCTGAAATGGTCGGTGCACCTGTTGTGCGCCGGTTGGCGGGTCTCGTCTTCGGTCATCCGAGGGGTCCCTGTGCCGTCTTCTTCCTCCGCTGTATCCGATTCCGGTCAACCCGTTCCGTCCAACTTGTGGCGGGACCGCGACTTCCGCAGGCTCTGGGTGGGCCAGACGGCCTCCCAACTGGGCGAACATGCATGTCTGGTGGTTCTGCCGCTCTTCGCCGTCCTGACGCTCAACGCCGGTGCCGGCCAGTTGGGCGCCCTGCGCGCGGTGGGGCAGGCGCCGATCCTGCTGCTGTCGCTCTTCGCCGGCGCGTGGGTGGACAGGTGGCAAACCCGCACGCTGATGGTGCTGACGGACGCCGGCCGGGCCCTGGCACTGGGCGCCGCCGCCGTGGCCGGCCTCCTCGGTGGGCTCGGCCTGCCGGCGCTGTTCGTGGTTGCCTTCGCCATCGGGGCTCTGTCCGTGTTCTTCGACGTGGCATACCAGGCGTCTTCGGTACGGCTGGTGAAACGCGATCAGTTGGTACGGGCCAACAGCGCGCTCGAGGGCAGTCGGTCCGCGGCACAGATCGGCGGTCCCGCCCTCGGCGGTGCGTTGGTGTCTGTGCTCTCGGCGCCGATCGCTGCCGCCTCCAGCGCAGTGTTTTTCACGCTGTCGTTCCTGTCGATCCGACGGATCGGTCGCCGCGAATCCATCCCGAAACGCTCGGAACGTCCTCCTCGGGTCTGGCGGCGGATCCATGAGGGCCTCCGCTTTGTTGCCCGCGACACCTCGCTGCGGACTGTGTGCCTCGCATCAGCCGCCTTCCAGTTCTTCTTCGCGGCTGTGATGACCGTCTATCTGCTGTTCCTGCCACGGGACCTGCACCTGTCGGGCACCGCCGTTGGGCTGGCACTCGCGGCGACGGGGCCGGGCGCGCTCCTGGGCTCGCTGCTGGCCGCCCGCCTACCGAGCCGCTTCGGATATGGCACTGTGCTCGTGTCCGCGGCAGCACTCGGCGACGGCGTGTTCCTGTTTGCGCCTGCACTGCACGGCACCTCTGTAGTGACGGTTCCCGCGCTCCTTACGGTCAACTTCGTCTTCGGGACCTTCAGCCAGCTGGTGAATGTCACGGTCATGGCTGTCCGGCAGACCGTTACTCCGGACGGGATGCAAGGCCGCGCGGCGGCGACGATCAACTTTGTCGGCATGGGGCTGACCCCGCTCGGCTCACTGCTCGGCGGCTTTCTCGCGGAAGTGTGGGGGACGCGCACCGGCCTCCTGGTAACAGCCGCAGGCATGCTGCTGTCGCCGGCACTGATGGCCCTGTCCCCACTCGCCCGCCTAGGACGGACGCTTCCCGCCCCGCCGGAGACTCCGGTCCCGTCTGCGTGACGGCTTCCGTCGCCGCGAATGGCCGACACAACTCCGTCGGCGGTCGTAGCCATCACGGAGTCGCGGGCACAACCAACGAGGGTGCTCAGTCACAGTTCGCTTGATAGATGCGTTTCTGCTGGTCGCGCGTAGGGGCGGCGGCTCTGTAGGCATAGTGGCTAGTCGCCTTCGGTGGTTGGGCTGCTGGAACAGCGCGAGCTGGATGCTCGCCGTCGTGGCGCTGGTGGTGCGCAGCTCCTAGTCGCGTACCAGGCGGCGGGTGAGGGGTGTCGTCGAGGCTCCGCGTCAGGACGGGGCGAGGAGGCAGAACTCGTGGCCCTCCGGGTCGGCGAGGACCGTCCACGGCACTTGGCCCTGGCCCGCATGGGCGGGCGTCGCACCGAGAGCCTGGAGGCTCGCGACCAACTCCGCCTGGTGGGCCGCAGAGGTGGTGGCGATGTTCACCTGGACAGGTCGCAGTGCCATGCCGGCGATCCTATGCACCCGTTCTGCCACGACATCCGCAGGTACCGTCGCCAAACAGAGATCAACCGCTCACCAGCCGCAATGGTCAGCTCGCCAACTGACCATGGGAGCGGCGGCCGTTGTCGCGACAGTACACCTCGCCCAGGGCGGCAGCGGTGATGTCGCGCAGTTGCTGTTCGGTTGCGTCGGTGGTTCTGGGGGGCGGCGGTGCGACGGCCTGCCGTATCTCGCAGCTGGCTGAGCGCTCCGGCATCCCCGCGGCTTTGGCGCGGCAGGGCTCGCTGCTGACGCGACCGCGGAATCTCTCTGAGTTCGTCACTGGGGCTCGGCCTGAGACGGCCGATGAGGGTCGGTGCGTACGTGCGCACGCAGCCCTTGCAGGCCGAACAGGATGAGAAGCTCGACCACGCCGCCATCGGCGCTGCCCAGCCAGTGCGGCAAGGACGTGTCGAACTCGGCTGCCTCACCGGGCGGCAACGTCAGGTCGCGCTCGCCGATCACGAGTCGCAGGTGGCCGTTGAGCACGTAGAGCCATTCGAAGCCTTCGTGGGTCTGCGGGGTCGGTTCGAGCGGTTCTGGCCGGGCGGGGATGATCATCTTGAAGGCGTGCACCCCGCCCGGTCGCCGGGACAGGGGCACAAAGGTCATTCCGTACCGTCTGATCGGCTTGAGGTGGATCCGGGGGTCGCCGGTGCGCGGGGCACCGACGAGGTCGTCCAGCGGAACGCCGTAGATCCGGGCCAGTGGCAGCAGCAATTCCAGGCTCGGCCGGCGCTGCCCGCTCTCCAGCCGCGACAGAGTGCTCTCCGACACGCCGGTCGTCGCGGCGAGGTCGGCGAGGGTGATGCCGCGGTCACGACGCAGTGCACGGAGCCGCGGCCCCACAGCGTCGAGTACGTCGTCGTCCGTCTTGGGGTCCATGAGGCCCATCTTGCCGTTACCGCAAGTTTTCGTGCCAGGTCGTGGTGTGCCTGGCAAGACTGGGCACCTACCGACACAAGGAGTCTCGATGACCACCACCGATGCGGTCGCATTCTGGGATGGCGTCTATGCGGCCCGGCCGGCAGCCGGCAACCCGCAGCCGAATGCTCGCCTCACCGAGACGGTGACGGGCCTGCCGGCCGGTGACGCGTTGGACCTCGGATGCGGCGACGGCGGCGACGCGCTGTGGCTCGCCGGCCAGGGGTGGCAGGTCACCGCCGCCGACATCTCGGCCGTGGCGGTCGAGCGGCTCGCGGCCCTCGCCCGCGCACACGGCTTGGGCGATCGCGTCACCGCCGTGCGGCACGACTTGCACACGTCTTTCCCGCCTGGCGGATTCGACCTGATCTGCGCCCACTATCTGCACACCCCCTGTGACCTGGACCGGGCCACCGTCCTGCGCTCGGCCGCGCACGCACTGCGCCCGGGCGGGCGGCTGCTGGTCGTCGACCACGGCTCGGCCGCGCCGTGGTCGTGGAACCAAGACCCCGATACTCACTACCCGAGCCCGCAGGAGGTCGCCGCCGGTATCGATCTGGCTCCGGAGACATGGACGGTCGAGCGGGCCGACGCACCCCGCCGGATCGCGACTGGACCGGGCGGGCGCACCGCCGAGGTCATCGACCATGTCCTCCTCATCCGCCGCACCGCCTGACACGGTGGCCGGCGCCCCCGCGACGAAGGAAGGCGACCACTGTTGCCCAGCGCCACGCGCCACAACCGCCGCAGCGACACCCCGCCGCCCCGGACCGGAAGCAGCGAAGTCGAGGTCCTGCGCACACTCCTCGACTACCTCCGGACCTCGATCTCCGCGAAGGTCGACGGTGCCCCCGAGCCGCAGGTGCGAGCCGCCGCAGTGCCGTCGGGCACGAACCTGCTCGGCCTGCTCAACCACCTGACTTTCGTCGAGCGCTCGATGTTCCTCGGGGACGACGTCACCGACTGGCAGGCGACGTTCCAGGCCGCACCGGCGGACAGCGTGGCCGATATCGTGGCCCGCTACCGAGAGACGGTCGAGCGCGCGAACGACGTTCTCGACGGGTGCACCGATCTCGGCGCCCCGGTCCCCCGACCGCGGCCGGGGCGCCCCGCTCCCAGCGTCCGCTGGGCACTGACCCACATGATCGAGGAGACCGGCCGTCACGCGGGCCAGGCGGACATCCTCCGCGAACTGATCGACGGCTCGACCGGCCGCTGATCCGCCTTCTCCCCCGGCGAAGTGAGGGGGCGCTCAGCAGCTGGGCAGGCGCGGAGCGTTACGCGGGCCAAGGCCACGGTGTGGGTGCTGGTGTGGGTGCTGGTGTGGGTGCTGATCGTGGTCGCCGTGCCGCTGACCTGGTGTGGCTGGTCCAGGTCGGCTACCGGGCTGCCGGGCAGCAGCTGCCCGGCAGCGACGCGGCGCTCTGCCCACGTGCCGGGCCCGGGTACGTAACCGGCGCCGGGCGCGGGACGTTGGGCACGTCGACGTGTGCATGAACATCCGCTACTGATACCAATTAGCCTGCCACCAGCCAGCGTTGTACGGCGTCCAGGTGTCGGCGCCATCCGATTCAATGCGTTCATGCACGAAGACATCTGGGGTGACCCCACACGCTACCGCTACGCCGCCGCTCCGCGGACGGGGTTGAGCCTGCCGCTCGACGACTCGCTGGAACGAGCGATCCAGGAAGCAGCGGAGGCCTCAGGCAGCGAGGACCAGGTCGAATTCCTGATGGTGGAGGGTCAACGCCTCACTGATCTGAGGCCCCTGGCGCGGTTGCGCGGGCTGCGGGAGCTTGTCGTCCATTCGCCTGTCCTGAAGGATCTCGGCCCGCTGGCCCTTCTTCCCACGCTGCGGCGGCTGTCCGTCACCGCACCCGTCTCGGATCTGGGCCCGCTGTCCGCACTCACCTCCCTCACCCACCTCGACCTGGAACAAACCATGGTGACGGACCTCGCGCCGCTGGCTTCGTTGGCCAAGCTGCGTGACCTGTCCGTGACGCAGGGCCCCCTCGCCGATCTCGGCCCGCTCCGCAGGCTCGGACTCATGCGTCTGTACGTCTACCGCACCCAGGTCACCGACCTGACGCCGCTGGCCGACGCGCCCCTGCTGTGGGTGCTCGGCATCAACGACTGCCCGGTCACCGACGTCTCCGTACTCACCCAACTGCCCAGCCTCACCCATGTGCTGATGCGCCGCACCCGCGTCAAGGACCTCGGCGACCTGCCGACCCGCGCCCCGCACATCACCTTCGAGGGGTACGACGAGAAGTCACCCGAGCCGACCGTCACGCCCGACACCCCCGGCGACCCCATCGACCCCATCGACCCCGCCGAACTGCTGGCCCGCTACCGCGCCGCCGAGGACAAGGAGCGTTACAGGCTTGGCCTACGGCTGCTCGGCAGCCGGGACGCCGTAGCCATCGAGGCGCTGATCCGAGAGCTACTGTCGGACAGCGACAGGTTCACAATGCGCGGACTGTTGCTCGACGGCGGACACGGGAGCATTCCCTTCCCCGCCAACCCCTGGGGTATCCCGGCCGATGCCGACCTCGACGCGGCGATCGGGCACATATGGGCCCCGCTCGCCGACCATCTGCCAACCTTCCTCGACATCCTGCGCCACGAGACACTGGCTCTCGGACTGCTCACCGACCAAGACGGCCAGCCGTCGCTCGCCTACGTGTTCGTGGGCTGGAACCCGCTCCCGGGCCGGGTACGCCTTGACGACCTGTCCCACTGGCGGGAAGACGAGGGCGCGCTGCGCATCGTGCACGGCGGAGCCCCGCGCACGGACATCGATCCATACCTGGTGGTGCCGGTCCTCGGCGGTCCCGTGCCGACGCCGCTGCGCGAGCTGTGGGCCGTCCACCGTTTTCTCGGCGACGGCTTCCAGGCGCAGTACGACGACCGACTGACCACAAATCTGGGCGCGTTCTGCTCGCGCAACCTCCCCGGGTTCGCCGAACGCAACAATGGCGCCCAGCCGGATCGATTCGTGCTGTTCGCAAGCCAGGACTACTACAACGCCGTGCTGGATCTCGACATCCTCGACCAAGCCGGCAACCCGACCATTACCACCTGGATCGACTGGGAGATCGGCGCCCGGCAGCAGTTCTGGGACTGGTTCGACGCCGAGCTGCCCGACACGGCCCTACTCGGCCTTCGACGGGAAGCACGGTAAGTCACACGAGCAGATACACCCGGTCAAGACGGGCACTGTGACACCGGTACGACGCTGGTCCTCGATGGGCCGCACGTGACCAGGAGCCGTCCCGTTTCTTTCTGGATGCGGGCACGCAGGATGTGCCGCCTCGACCCCATGCCCTCCGGCTGCGCAGGTCGCGACTTCGGACGCACTTGCCGTCGCATCGGCGGCCCCGGCGCCGCCCGGAGCGTTGATTGCTAGACCTTGAAAGTCTAGTCTTGGCGGGACGCGCCGTTACCGGTACCCGATGGAGGAAGCGTGAGAGCCGACGACAGCACGGCGCGCCCCGGCCGCCTGGTCTGGATGGACACGGACCTGTGGAAGCAGCAGGTGAAGCGGCGAGCCGAGGACGACGGCCTGGCCCGCGCCCGCTCGCGGGTCCTCGAGGCGCTCCTGACGGCGTACGCCGAAGGGTCGCTCGACGCGCCCGTTCCGGCCGGCAGCACATTCGGCACGGCGGAGCGGGGCGGATGCCGCGTCTACCTCGCTGAGAGCGTGTGCGAGAGGGCCGAGACCAGGTGGAAGAGGCAGGAGCAAGCCCGTCGAGGAGGCGTTCCCGGGTTCGGGCTGCTGTGTGAGGTGCTGCTGAGGGAGTATGCCGAGGGACGCGTCGAGCTGCGGATCACCGCGGCTCCCGCCGGAAGCACAGGGAGCACGGGGAACACAGGGAGCATGGCGGCATGAGCGAAGCAGCAGCGGACGGGCACAGGCCCCTGATCCCGCAGCCCAAGACCACAGCGGAGGACCTGCGCGCGGCTCTGGTGCAGATTGCACCGAACCAGGTGGCCGCGTTCGACGCAGAGCGGACGACGGCGGTGGAGGCCGCCCGCAGCCAGGTCGACGCGGCCCCCATGCGCCGGTTTCTGCGGCGGTGGGCGCTCGCGGTGGCGATCGAGCGCGTTCCTGCGCGGGCCGCACGCCTGAGCGAGCTGGAGGCCCGCGCGGGGCAGGTGGAGGATCTGGCCGAGGGGCGTGCCATCGCCGCCGAAGTGGCCGCCATCCATGCGCAGGCGGCGGCCGAGGCCGGAGTCGACGGGCGGACCGCCGAGTGACCGAAGACGCCGGACAGGGGTGGCGCTGGGAGTACGAGCCCGACTACGAGTACGTGGCGAAGGGGTTGCCCAAGCGCGTGGTTGTGGAGGTGGAGCGGCTCGCCGGGCAGCTCGTGGACCTGGCCGAGATGGGCATCGACGTCACGGCCGTAGGGGACGGCCCGAGGCCGGGAGTCGCAGGCGGCGTACGGCGCCTGTCGGTCCTGGAAGACGGGTTCATGCTGGTCCTGCCTCTCCCCCGGCTGCGCCTCGTCGCCGTCACATACATCTGCCCTCCGTTCGCCGACCTGTAGCCCGCCCCTTTCGTGCATCCGAGGGCCGCAACCCCGTTCCCGTCCCGGGAACGGGGTTCTGCTGCGCATCGTGCCCGTGCGACGTCGCCGGTGCGTTACCGCAGCGGCCGGTGCAGGCGCTCGTCGACTCCTCGTCGAGCTCGCAGCCGAGCGCATCCCCGGATCTGAGGGCGGCGGCGAGCGGGGCGCCCGGATTGGTCTGCGGAGTGATCTGCCCCAAGGGGGCGGTCCCGCGCGGCGGGTGGACTGAGCGCGGGACCGCCATCCGGCCGTCCTGTCCGGCCGATGATGACCGGGGGCCGGCCTCCTTCACCGCCTTCAGCACCACCCGTGCCGGATCAACCCCGGACAACTGCCGCCCACCGGCCGCCGCCGGGCAGGTCAGCGGCGCAGTGGGCGGCGAGGAGTGGTCGACACGGCACCCGGGACGGGCCGCTGACCGGGGTGACGGTCACGGCCGTTGGCGACCACCTCGGTCACTTCGACTACCTGCCCAAGCGCGGCGAGCAGCCCGACGCAGCCACTACCGACGACGCCTCAACGACCCATCCCGCACATAGATCGCGAACCAGACTGGAGTACTAGGAGCGCGTCCGGCACAGCTCCTGGTCCACGAGCGTGCTCATGGCCTGCTGGGTGTTCCGGCCGCCGTCACTGGTGACGTACACCACGGCGGTCCGGGTCCCGTCTCGGGTGACCCCACCCCAGGTGCGATAGCCGAGCAGTTCGCCCGGGTGGCCGAAGTAGCTGCCGCCACAGGACAACGGGATCTCGCCCAGGCCGAGTCCGTACCTCACGCCCAGCTCGGGCGCGGGCTTGGTGGTCGTCATCTCATCGAGCTGCGCCGGAGCCAGCAGACGGCCGCCGAGCAGTGCGGTGTAGAACCGGTTCAGGTCGTGCGTGGTGCTGATGATCGAACCGGAGCCGACGGCCATACTCGAATTGAGCACCGTGACGTCAGTGCGGGTGTGGGTGCCGAACGCGGCGTAGCTGTGGGCGTGCGGGCCCAGGATGGACGGGAAGGCGCCGGGCATACTGGTGTCCCTCAGGCCCAGTGGGCGGATGATCCTGTCGTTCACCTCCTGCGCCCAGCTCCGGCCGGTGACCTCGTGGATGATCATCGCGGCGAGAATGTAGTTGGTGTTGGAGTACGACCAGCCGTCGCCCGGGGGGAAGTTGGGACGGTGCTGAATCGCCAGCCTCACCAACTCCTCGGGGGTGTAGGTGCGGAACCGCTCGGCTCGATAGCCGTCCGCGCTGTTCAACGCGGGTATCTCCGGCAGGACGTCACGGATGCCGCTGGTGTGCTGCAGCAGCTGCCGCACGGTGATCTGGCTGCCGTCGTTGTCGTTACCCCGGACCACTCCCGGCAGCCACTGCTCGACGGTGTCCTCCAGGGACATTCGCCCCTCGCCGACGAGTTGCAGCACGACCGTGGCGGTGAAGGTCTTGGCGGCGCTGCCGATCCGAAATCTGCCGTTCCGTGGCATCGGCCTCCCGGTGCCCAACTCGGCCGTCCCGGCGCGCGCGCTGTCACGTGTGTCCGGTGACGTCACCTCGGCGAGCACACCGACGGCCCCGGTGTCGTGGATCGCGTCCACCTGCTGTTGGAGCGGATCGGCCTGCTGCGGCTTCGCCGCCGCCGTCAGCCCGGTCGACGCGGCAAGGAGAACCGCGGCCAGGCCGGTCAGGACGAGCGGGCCTCGCCGACGCCTTCCTAACACATGCATGATGATCCCTTTCCTGTTCGGGCTGCCTGTGCGTTCAGGGACCGCGCAGGCTGTGACCCGCGGCTGTTTCGCCCCCGGAGCCGGCGGTCGGCGACCATCCCACCAGCGGAGAGGGGATCGGCCCATCCGGCTCTCCCCCTGATGTGCCGATGCGCTGCCCTCAGGGCAGTGCCTGGGGTTACCCCCCGTAGGGACGCGAAGGCTTCCCCCGGCCGGCCCTGCACAGCGCCGGCCCTGAACAGCGGAGACAGCGATCCGCGGCTGGAGTACCAGGTGATCAGCACGCCAACGTCAGCGCGGCGCGAGTCGGCTCAGCCGGCGTTCTGCGCGCCGAAACGCAGGCCGTCGAAGAGGATCGCCGTGATGCGCACGGCTTCGTCCTGCCAGCCCTCCGTGGCGTGCATTCCGCAGATGCCTCCCAGCGCGCGCAGGAGTGTGTGTCCGCTGACGCCACCACGGATGGTGCCGGCCGCTGCGCCCGCCTTGAGGAGCTGATCGAGAGCCTGCGCCATCTGTGTGCGGGCGTCGTCGAAGATCGGTGAATCCGTCGCCATGATGCTCTCCAGCGCGACAGCCATTCCCTTGCCCACGGCTGCGTGCTCCACGAGCAGCAGCAGGAAGCGCCGCAGGGCCTCGTCCGGGGCATGGCGGTCAAGGAGCTCCGCGGGTGCGGCGCACAGCTCGTCGACCTCCTGGCGATAGACCTCCTCGACGAGGGCTTCGCGTGTCTCGAAGTGGCGGTAGAGCGTCCCGACCGCCACTCCGGCTCGCCGGGCGATCTCTTTGACGTGAGCGTCGGTCTCGCCAGTGAGGAATGCCTCACGCGCCGCGGCCAAGAGCGCCTCGCGGTTACCTCGCGCATCAGCGCGCAGCGGACGTGACGACGGCAACAGTACCCGGCCAGGCGACTGCCCGTCGATTCGCCGCTGCAGGCGCGACGGTGCTGACCGCCTCGCGCAGCGCGCCCCCGGAGGATCTGCCGGCCATCTTCATCCCTGCGGACCTCGCGACTGATCAAGGAGTAGCGGAGCTCGGCCGACGGGTCATCGACAGCGTCGGTGGGGTGGATGTCCTGGTCAACAATGCGGGCGCCGCGAGCGCCCCGACGCCGACCCTGAAGCGCTCCGACCAGTCGTGGCATGCGGACCTGGAGATGAACCTGCTCAGTGCCGTCCGGCTCGACCGGGCCCTGGTCCCAGGGATGGTTGAGCGGGGTTCCGGCGTCGTCGTGCACGTCTCGTCGATCGCCAGTCGTCTGCCGCAGCGCACCGAGGCGTCCTACGCGGCGGCGAAGGCGGCGCTCAATGCCTACAGCCGCGAGCTGGCGACCGAGGTGGGCGAGCACGGGGTGCGCGTGGTGTGTGTCATGCCGGGCTTTGTGGCCACCGAGGGCGCCGTCGAGCACCTCCAGCGGATCGCCGATCGGCAGGGTGTTGGCGTGGAGGAGTACAGCAGCAGGTCGTAGATCACCTGAACGTGCCGATGGGTCGGCCCGGCGATCCCGAGGACGTGGCAGAGATGATCGCGTTCCTCGCATCCGGCCGCGCGAAGTGGCTCACGGGAGCCGAGTTCCGGGTCGACGGCGGCATCATCCCGGTGGTGTGACTTCGAGGCCGAGCAGGAGCAGGAGCAGGACAGAGAACAAGCATGAACATCAACCTCAGCGCAGTGATCATCGATGCCGCCGACCTGGAGCCCGAGAGTGCGTTCTGGCACCGGCTGCTGAGCGGCTCGATCGTGAAGACCGCAACCCACCACTTCCTCCGGATCGACGGATTCCCGGTGTTCGTGATCCAGCTGGCTCCGGGGCATGTCCCCCCGCAGTGGCCAAAGGGCAACTCGCAGCAGATGCACGTCGATCTGACGACGGACGACCTCGCGGCCGCGGACAGGCTGGCGCTCGAGGCAGGTGCACGTCGGCTGCATCCCACTGACGATGTCGACCCCGCCTCACAGAAGGGCGGCCGGGTCTACGCCAGCCCGGCCGGACATCCCTTCTGCCTCCGGTCGGGCTGAGCCGCGCCGAGCGCCTGGGCCTGCTGCTCCCTGCTGTCTCCGAAGCCACTGGTCACCGCGACGACCCGCGACCGCCGCGACAGCGCCCAGGTGCCGTCGCTGTTCAGCCGACACCGAACATGGACGTGCGAGGACACCACGCACAACGCAACAGCGGGCCGAACGACATCAGAACTCGTCGATGTTGATCAAGTAGATGACCTCTGAGTGACTCCTAAAACCATCGACAAACAACTCCCGCCACATGCTCACCCGCCTGCAAGGCGACCAGCTACCCGAATGGACCGAAGCAGCCGTCCGCCACCACCGAACTGCCCAGTCTCCGCCGGTTCGCCCAACACCTCGAACACGACGAACTCCTGCGCAAACAAATCCTGTTGGCGTGCCCGAGCATGTGGCACCTGAGTATCGAACTTGGTGCCTATGCGAAGCCACCGTTGCTCATCAACAGCTGGCCGTTTATCCACTCGCCTTCCCTGGAGCACAGGAAGTCCACGAGGTGGGCGGTATCCCTCGGAGTGCCCAGACGGCCAAGCGGGGTGCCGCGGACGCAGCGCTCCCGGATTTCTTCGGACATCCAGCCGGTGTCGACCGGTCCGGGGTTGATCGCGTTGGCGGTCACGCCGAGGTGGGCGAGTTCGCGGGCGGCGGCCAGGGTGATGCGGTCCAGGGCTCCCTTGCTCGCTCCGTAGGGCAGGTTGCCGACGGTGTGATCGCTGGTGAGGCTGATGATCCGGCCGGTTCCCGGGGCCGCGGCAAAGCGGCGTCCGAACTCGCGGATGAGAAGCCAGGTGGCGCGCGCGTTGACGGCGAAGTGCCGGTCGAAACTCTCGACGCTGGTGTCGAGTAGACCGGAATCGACAGACTCGCAGTGGCACATCACCAGCGCGGCGACATGCCCCAGCCGCTGTTCGGCTTCATCGAAGATGCGTGCCGGGGTGTCCGGGTCGGAGAGATCCGCCTCGATCGCGGCGGTGGCTGCACCGTGTTCGGTCAGGGCTTGGCTGATCTCATCGGTCGCACCGGGCTCCCTGCCCCAGGTCATGCGGTCGTCGTAGGGGGCCCAGTAGGTGAAGGCGATGTCCCAACCCGATGCGGCCAGCCGACGAGCTATGCCTGCGCCAATACCGACGGTACGGCCCACACCGGTAATGAGGGCGAGCGGGCGGCCAGCCGAAGGAACCTGTCCGTGGGCGGGCTGATCATGATCGGTGCTCATCGTCACGGTCCCGCATCGTTCACGAACAGCACCGGAGCGTCAATCGCTTTTGCTGCGACGAACCGTGTTCCGGTGATCGCTCGGCTGGTGCAGGCCGGAGGACACAGTGCGGGAGGTGATCCACCGGATCGACGAGATCGGTCCGGCCTGCCTGGACTCTCGATGGGCGGGATGCCGTCCCCGCCTGCTCGGTGATGACGACGAGGACTTCGTCGTCCAGACCGCGACCACCCGTCCCGCCAAGCTCGGCCAGTCCTTCACCCGCTGATCGATCCGCGAGCTCGCCACCTACCTGCGCCACGTCCACGGACGCGTCATCCGTATCGGCTGGGAAGCCTTACGCTGTCTGCTCCTGCGGCGCGGCATCGCCTTCCAGCACACCAAGACGTGGGAGGAGCCGCCCGGTCCCGACCGCGATACCAAGCTGGACCGGATCGAGCAGGCGCTGGAACGCTTCCTGGACCGGGCTTCGCCTTCGACGAATTCGGGCGGCTGGGGATCCGGCCCACCCACGGCTCCTGCTGGGCGAGGCATGGCAAGCCCAACCGGCCCCGGCGACGCACGGTCCGGCACAGCCGTCGGGCCGGAGGGCCCCGCCCAGTTCCACCGCGATTGACCGCAGCCCGCCTGTCAGCCCGGCACTGGAGCAACGGTGCCGCTCGGTCGGGCCACCGTCCTGCTCAGCTACGCGGCGACATCGGCCCCGTCCACCGCCCAGGTGCATATCCCGCAGGCTGTCATCCAGCAGACTGCGGCAGGCGATGTCCGCTGGACTGGGCGCGGGCGACCCGGTCGTCGAACGGTGGCTCGCACCCCAAGTCAGCTGCGGCGTCCCTCGCGGTCGGCCTGTGTGGCGTGTGAAGCGAGGATGCGCAGACGGTCGTGGCTGGGTGTGCCGGGCTCGGCGGTCAGGGTGATGAGCTGCTGGTCGGGGTCGTCGGCGCAGGTGAGGAACGACCAGTCGAGGGTGAGCCGGCCGACGACGGGATGGTTCAGGGTTTTCGTGCCCGTGCCCTGGACGGCGACGTGATGGGCGCCCCACCACCGCCGGAAGTCGGGGTCCTGAAGTGACAGCTCGCCCACCAGTACGGCCAGCCGTGGATCTTTCGGGTCCCGGGCGGCCTCCATGCGCAGCTGCGCCAGGCTGATCTGTGCCACCCAGTCCCAGTCCGGGTACAGCGTTCTGATGGCCGGTTCGCAGAAAACCAGCCGTACGAAGTTGCGATTCCCTTCCGGGATCCGCGCGAAGTCGGTGAACAGGGCGGCGGCCATGGGGTTCCAGGCGAGGATGTCCGTGCGCCGGCCCAGGACGACGGCCGGCGTGGTGGGCAGGTCGTCCAGCAGCCGCTGCAGCTGTGGATGGACCTTCTGCGTGGCGCGCCGACGGGGCCGGGCAGCGTCCCGACCGGACAGCTCGAACATGTAGGCACGTTCGCCGTCGTCGAGCCGGAGAACACGCGCAAGGGCGTCCAGCACCGGTTCGGAAGCCTGGCGACGGCCCTGCTCCAGGCGCGTGTAGTAGTCGGGGCTGATCGACGCCAGCAAGGCCACTTCCTCCCGGCGCAGCCCCTTGACCCTGCGCCTGCCGGCCGAATCGGGCAGCCCGACCTGGGCCGGGCCCAGCTCCGTGCGCCGCGCCTTGAGGAAAGCGCCCAGTTCGCTGTGGTGCGCGTTGCTGCTGCTCATAGGCCAAGTCTTACATCGCACCATGCCAGTGACAGGGGGCCTGGCCTGTCCCAGGACAGCGTTGTCCGGGGACACAGGACGCCCCTTACCCAGCCGCGTACTGCGTGCGAGTGTCGGTGACGTGACCGGGCGGACGGGCCGCCCCGAGGCGGGGCCTTTGCCGGAGGAATCCGTCGTGTCGGCGGTCACAGCACTTCTCATCTGCACCCAGGAGACACAGAACGTGAAGACCAGCGTCACCTTCCCCAGCAACAATCTCGCCGTCGCCGGGATTCTCTTCACCCCCGATGACCACATTGACGGCCGGTTGCCGGCCATTGTCATCTCCCATCCGGGAGGCGGCGTGAAGGAGCAAAGCCCGAGTATCTACGCCGAGCGCCTGGCCCGGGAGGGATTCGCAGCGCTCGTCTTCGACGCCGCCTACCAGGGCGAGAGTGAGGGCGAGCCACGAGGCATGGAGAACCCCTTCCAGCGGGCCGAGGACATCAAGTCCGCCGTGACCTACCTCACCACCCGTGACGACATCGCCCCGGACCGTATCGGGGCTCTGGGTATCTGCGCGTCCGGCGGTTACGTCCCCTACGCCGCGCAGACCGACCACCGCATCAAGGGCATCGCCACGGTCAGCGCCGTCGACCTTGGGTCAGTGTTCCGTGAGGGACTGGGCCGCACCCAGGACCTGGCGGTCCTCAAGGCCATGCTCGACCGGTCCGGTGCACTGCGCACCGAGGAAGCACGCGGCGCGGCCCCACAGCTGGAAGCATGGATTCCCGACAACGCAGAGGAACTGCTGGAGACCGCCACCAGACAGTTCCGGGAGACATTCGAGTACTACCGCACCCCGCGCGGCTACCACCCCCGCGCGGTCCAGGGATGGGTGCTGCGCAGCATCGACCTGATCGCCCAGTACGACTCGTACGCAATGATCCGGCTCATCTCGCCCCGTCCCCTGCTGATGATCGCCGGTTCGGAGGCGGAGAGCGCCTACTTCAGCAGGGAAGCGATCGAGAAGGCGGCCGAGCCCAAGGAACTGGTCGTCATCGACGGCGCCACTCACATCGACCTGTACGACAAGGATGAATACGTCACACCCGCCGTCGCCAAACTCACCGAATTCTTCGGCAAGCACCTGGCCGGCTGACCGCCTGCCGCGCCCGCGACGGTGTGGCAGGCCGGTGGGTCTACCGCGAAACCACCTACGTATTCCAGGCTCTGGTGTGTTGCTCCAACTCACGCTACTACAGCGGTTCATGGCTGAATCGAGGATTGCCGGTGTCCATCGCCGACTGCCCCGCCGGCACAACAGCAACCAACTGGTGGGTCAGCATCCCCGGCTGATCCCGGAAAACAGAGCCATACCTGCCGCCCGCAAGCGACACGACGGCCCCTACCGCCTACGGCAACTGGCGCGGCGGTATGCCGGTCTCGTCGCGAGTGAGCGGCTCGCAGAGATGCTGAAGTGCCCACCGTCGGGTGGCGCAGGTGTCGTAACCGCCCATCGGCGGCGCCCAGGATGTGTGCGGGGATGCCCAGATGGCGCTCCTCCGCCTCGCCGGTACGTTCGCCGAGGCCCCGAAGTCGACGCCGACCGGATCGGACTGTAGGTATCCGGCTGTGCCGGCGGACACGCGATCGTGCTCGGAGCCACCGACCGCCGCCTGAAGGCCGTCGTCGCCCAGGTGCCCACCATCAGCGGGTTCGAGCAGTCCAGGCGCCGCGTCGCCCCCGACAACATCGCCGCCCTGGAAACCGCCCTCGACGCCGACGAGCGTGCCCAGCTGACCGGCGAGGCACCACGCACCCAAGCCCTGGCCAGCGCCGACCCAGCCGTCGCTGCCTCCTACCGCGCACAGGATGCTGTCGGCTTCTGCCTTCAGGAACTCCCCCAAGAACACGCTGGGACAACTGCGTCACCGTCCGCCCCACCCGCAAGGCACATGTACGAACCGGGCGTCTTCATCGACCGTATCTCCCACACCGCTGCTGAAGATCGTCGGTGAGCAGGACACCGTCACCCTCACCGACCCAGGAGTGCCAGGACTACGCCGACAATCGCGAGGTCCCTGGCCGCGGTAAGCGCTCGGGGGAGCCGTTCCAAGGCCGATCAGGACCCCGGCCAGTGGCTTCCCACCGGATTCGGGAGTCCGCGGCCGGTGCATCGAGGATGGACCGTGGTGAAGTCCCGCTGGGGACTGTCGGCGGACCGGAACAGAGCAACCGCTCCAGCCGATCTCGCCGACAGCTACCCCGGCGCCCGGATCACCTAGCTGAAGCCAGTAGACCCGCAGCCACCGCGTAGATGTACCATCCAGCACCAACATTGATTGCGCCCCCAGACGAGGGAGCTTGTGGTGGACACCTCTACCGATAACACCAACCTGAAGTCCCAGTACGCGGCACAGATCACCGCAGATCTCGAACGCAACTCCACCGAGCACGAACGCCTCAGTACCGAAATCTCGGCGCTGCAACGGCAATTGTCGGTGCTCGAAAACAACCGGGTGCTCCTGCTCAGCATGCGACAGACCCTCGGTGGCGGAACCGCCGCCGACGTGCCGGGGAACACCGGCGTCAGCAGCTCTGAGGATGAGTCGTCCGCTGCGCGGGAGTCCGCAACACTGCCGGCAGCACGCAAGCCAGCGAAGAAAACCAACACGGCCACCGGCAAGCGGAAGGGGGCAGAGTCGGACGGGAGCCGTCCCAAGCGGGTGCGAGAAACCGGTGTGCCAACACTCCGGGACCTCATCCGTGATGACCTCATCCAGCACGGTGAACCGCGCTCCGCAGCCGAGGTCACCACTGCCCTCACCCAGGCTCTTCCGGACCGCGAGATCAAGGCCACCGTCGTGCGCAGCACTCTCGAGTCGCTCGTCGCCAAGGGGCAAGTACACCGCACCAAGCAGCAGAAGTCCGTCTTCTACTCGGTTACCGCCCCGGACACGGCCGCCGGTACGTCTGAGCCCAGCACGGCATCCGCTTCCTGAGACCTGTAGGACGACCGCACGGGGCTCGAGAAGAGCCGACCCGACGCCGCCTTTTGAGAAATTGGCACGCGCGGGGATGGTGAACGTCGTCTCCTGTGCTGCGCTCCAGCCAGCCTGCCCGGCGCACGACCTCCCGCGTGCCGGGAGGTACTCCTCCCGGCACGTCGCGCTACGTCCATGTATGGATCACGGGTGGGTTATGGCGCCGGCATCAGCGTACGGTTCACCGGCTGGCCGGAGCGAGCCATGGACGTGTTACTGCACCTGCCGGGCCAGCCCTCAAGCGCGGTGCGCCAGCAGGGCCCCCCACGAGGTGATCCGTCCGACCACTCTCGCACGGACCTGCTGGCCACCGCTCACTGATCGCTGCCCAACCCCTCGGCTGCGACGACTGGCTCCACACCCCTGAATCCATCGGCAAAGTCCTCGCGGCCGCCGACGACCTGGACCCCATGCTCACATGGCTGATCCGTCACGCACGTGAACAGCTCCGCCTGACACCGGAAGCGCTCCGCCCGCGCCGTACGCGTACTTTCCCCCCGCTGTGCTGTTCGACCTGACAGACGCGCTGTTACGCGCCGACGGCTCCGTCAGGTACCGCAGCGGTCAAGAACCGTCACGGCCTGACGGACTCCACGAGTTCAACCCGAGAGGTCACATCGGTGTGATGCCCGGGCTCATGGGTGTGTGCGAAGGGCGCACTCGATGAGGAGGACATGATGCGGTTTGTGTTGGTGATCCACCAGGGCACGTATCCGTTGCCGGGCACTCCGCAGGCGGAGTTGGTGTCGGAGGAGGACAGGAAGGCGGCGTACGCCGACTGGGCGGCGATCGGCAAGATGGAGAACGTGACCGGTGCGCCCCCGATGGGGCTGCCCAAGGACGCGACGACCGTCCGTGTGGAGGACGGTTCGGCTGTTGCCACCGAGGGTCCGTTCGACAACACCTCGGTGGGCGGGTTCCTGGTGGTCGAGGCCGAGGATCTGGATTCCGCGATCGCGATCGCATCCCGCGTACCGCAGGCGCGACTGGGTGGCGCGGTCGAAGTACGACCGTCCGCCAAGTACTGGTGAGTTCCTGGCCCGGTGCGCGCCGCGCACCGGGCCGGACCGCTCACTCGGCTTGGCCGAGAACGCTGGACGCGAGGCTGCGGACGCGGTCGGCGTTGCGGATGACGTCGATCCTGACGATCTTGTCGCCGGTGACGGTGAAGGCCATGACGGAGTACGGTTGTCCATCCCGGGTGACCAGTGACCAGCACGCCGACCGTGCCGTTGACCAGGACGGGACGCAGTTCGCCACCGCGGGGCGCACGGGCCTGTTTGGCCACCGCCGCCGCACCACGGACGACGCTTGGCTGCCGGGTGGCACCGAACTCGGTACGCTGCACGACATCGGGGTCGAGGACCTGGATGAGGGCGTCGAGATCGGCAGTCCGCGCCGCCGCGTAGAACGCGTCGACCACCTTCCGCTGACGCGCGAGATCCCGATCGGGCCGGGGAATCTCCGCGCCGTTGACCCGACGCCGCGCTCGGCTGGCGAGCTTCCGTGCGGCCGTGGGGTTTCGGTCGATGATGTGGGCGATCTCGTCGAAGGGCAGGTCGAACATGTCGTGCAGCACGAACGCCAACCGTTCTGCCGGGGTGAGCCGTTCGAGTACGACAAGCGGCGCCAGGCCCACCGCGTCGGCCAGCAGTGCCTCCTGCTCGGGGTCGGGGTCTCCAGCCCGGACGACCGGGTCGGGCAGGTGCTCGACCAGCGGGTCTTCCCGGCGGCGCCGTCGGGATCGCAACTGGTGCAAGCACTCCCGCGCGACGACGGTGGTCAGCCACGTCTTGGAGGCCGTCCGCGGCTCCTACGACCAGGCCAGGGCGGCGATCGATGGGCGATGCGGGTAGGTACTGGGCAAACGGCAGGCCGAACAGCTCGTCATCGCCGCAGCACAGGACATCGACGCCTTCTACCGGCAGCGATTGCGCTGCCGACGACCGCCAAGACCACCTTGGTCCTGCAGTTCGACGGCAAGGGCATCGTGGTACGGCCCGAGACCTTGCGACCCGCCACCCTCAAAGCGCACCGCACCAGACCTCCCTGCGGGCGATGAGCACCCGGCTGCCCCGGGAGAGAAACCGCATCGCAGGCGGATGGCCACCCTGGCCACCCTCTTCGACGCCGACCCCGCACCTCGCCGGCCGTACGACATAGGCTGACGCTGTCGGCGTCAGCGGGTCGACCGGCGGATGCCGCGGGCTACCACGAGCAGGCCGACGGTCAGTACCGCCACCGCAGCCGCTCGGCGCGCACCCGAGCCTCCCAATCCTGGCCGCCACCCCGCTGAGGCTCGCCCGCTCACTGGCACCGGTCTTGGCCGCCCTGAGAAAAGTCGGCCCCTCTGATCCGTCGTCACATCCGCCCGGACCTCCCAGCCGAGTTTCCTGGTGTAGAAGTCAAGCGCCTCGTCCTGGTCGTGCACTCAGAACTGCACATTCGCGATCTTGGTCGTACGCCTGCGGGGTCATCCCGCACATCCTGCGGAACTCGTCGTGAACGAACCGATGCTCCGCACGCGGTGTGGCCCTCGATGGCGCCCCGGTTGGAGTCGTAGATCCAGCACAGGGAGCTGGGCGGCTTCTGAACCGCTTCAACTTACGGCCGGGTTTGGGCATCGGGTCATTCAGGCCTCGTCCGCAGGTCTCTCCGGCTCGGCGTCGTCGTGCCGCGGCCACGGTGCGGGGCGCCGCTGTCGGCCACGGCGTGGCCGGCGCCGCGGCCTTCCGCGTGTGCCACGATCAGCCCGTCACGCACCCGGATCGCGATCTCGGTGAGGTCGTCGACCGAGGTCCTGCCGAGGGCAGCGGGAACCGTGCCACCGTCGTCGAAGACGATGCGCGGCCGCGGTAGTTCCTCGGCTGCGAACACCCGTCGCAGGCAGGCGACGAGATCGGCGATACGGAGGCGGGCCAGTCGACCGGTCTCGGCCGGGTCGCTCGTGGTGACGACGATCGTCACCGCGTCGCGTGGCCGGGCCGAGCGGACCGCTTCCTCGGCCGCGGACAGGCGGCTCACGCCCAGTAGGACGACCACGCCGTCGTCAGTGAGGTCGACCGCGCGGCCGGTGATCTCGTCGGCGAGGCCCCGGGGTGCCGCCCATGGGTCTTCGGCCGGCTGTGCCCGGGGGATGAAGGGCAGGTGCGGTGGCTCCGCGTCGTCGTTGAGGGCGATGTCGGCCAGGTGCTCGGCGGCGCGGGCCAAGTCGAACGGATCGCCGACCCCGGGGGCGTTCTCCGCGAGACCGGCCGCTCCGTGGAGGAGGGTCAGCGCCAGCTGGGCCGGTCGCACCATCCTGCCGCGCGCCGCGGGGCGCGACTCGAGTGCCAGGGCGAGCAGCAGGGCTTCGAACCGGACGAGTTCGGCCAGCGCGGTCCTGGCCGGCTCGGTGTCGAGCACTCCGGACAGCGAACGCAACTGGAGATGCCCGCTTCCTGGTGTGTCGCCGGCGAGGGGCAGTCGTTCGAGCCAGACCCGGGCGAATGTGCCGAGCGCTCGCCCGACGGAGTCGGGCGATTCCATCGGCGGTTCGGCGCGGGCCCTGGCCCGTTCGGCGGCGTCGGCGAGCACTGCGAGGTAGAGCGCGCGCTTGCCGGTGAAGTTGGAGTAGACCGCACCCCTGGTCAGTTCGGCTCGCTCGGCGATCCGGTCGACCTTGGCCTCGGCGTAGCCGTGCTCGGCGAACTCCTCCCGGGCCGCGACCAGCACCGCCGCGCGGGTGCGCTCCTGCTGCTGGGCGCGCGTCAGTCTCGCCATCGTGTCCCCTTCCACTTCCGCATCATGATACAAACAACATCCAGATGACGACGTCATCCAAAAAACGCGACCATCGGAGATTGGTCATGGACGGCAAGGGGCTCGATGTCGACGAACTGGCCAAGAGGTTCGGCCGGACAACCGCGGTGGTCAGTGTCCTCGTCAGGAGCGCCGACGCCGTGCCGGCGTTCAGCTGAACGGGATACAGGAGTGACGATGCCGACCCGACGGCACCCAGCCAAGGCGCAGCAGCACCGCGAACCGTCGACATCCCGACTGCCGGGGCCGGGCGACGACCGGAGGACCACTCATTTCGCGCCGCGAGCCACCGACAGCCTTCCCATGAACCGAACCGCACACCCAGGGGACAGGACATGACCCGGTCCGAAACTCACACGACGAACGCCAACTTGTTGGTGCTGCATGCCCTGCGTTGCGCCGGCGCCGCCGGCCCCGCCCGCCTCCACGCGTTCACGGGACTCGACGAGTCCGATGTCGAGTCCGAGCTCATCGATCTCGGGGCCGAGGGCCTCGTCACGCGGATGTCCGGCGACATGCCCTGCTGGCTGCTCACGGATACCGGCCGCGCCGCCGACGCCGAGCGCATCACCGACGAACTCACCTCGGCCAACGCCCGCGGAGCCGTTGAGGCGGCATTCGATCGGTTTCTCGTACTCAACCCGGAACTGCTCGACCTCTGCGCGGCATGGCAACTCCGCACCGTCGACGGCATCATGAACGCCAACGACCACAGCGACCCCGTCTACGACTCCCGGGTCCTCGACCGATTCGCCGATCTCGACCGCCGCGCCGCCCCCGTCTGTGCCGAGCTGTCCGCGGCACTGCCCCGATTCGGCCGTTACCGCGACCGCCTCGCCGGAGCCCTCGATCGCGCCGCCTCCGGCGCGCTGGAGTACGTGACCGACAGCACCGCCTCGTATCACACCGTATGGGCGGAGCTGCACGAAGACCTGCTCGCCACCCTCGGGATGCGGCGATGAGATGGGTTCGCGCGATCTCCTCCCAGGTCGAGGAGGCGGCGGAGACTCTGGGAGGCAAGGCAGTCGGCCTGGTCCTCCTGCACCGCCTCGGGTTGCCGGTGCCGGCCGGGTTCGTCATCACCACACAGGCATGCCGTGCCTTCCTACGGGACGGACGTCTGCCCGACGGACTCGACGACGAACTCGCGACGGCCATCGCCGACCTCGAAGTCACCGCCGGGCGCTCCTTCGGTGGACCGAGGAGGCCGCTGGCGGTCTCCGTGCGCTCTGGGGCCGGCGTGTCGATGCCCGGCATGATGAGCACGATCCTCAACCTCGGCCTCACGACCGAAGCCACCGCGGGCCTTGCGGTCGAGACGGGCGACCGGCCGTTCGCACTGAACTCGCGGCTGCGCTTCCTGTCGAGCTTCGCCTCCGCGGTCACGAACGCGGACGCGGGCGGCGTAGGCAACGCGAGCGACGCGGGCGACGCGGGCGACGCGGGCGACGCGGGAGTCGGCCACGGAGAAGATCCCGGGCGAGGAACGAAGGACGAGGAAACGCGCCTCGCCGATGCGATGAAGGCAATCGAGGAATTCGTTCGACAACGGAGCGGACAGCCGATCCCCGACGACGCGACCCGCCAGCTGGCGTCGGCGGTCGAGGCCGTGTTCTCGTCCTGGGACACACCACGCGCACGAACTTATCGCGCGTTGCACGACATCCCGCACGACCTCGGAACGGCCGTGATCGTCCAGACGATGGTGTTCGGGAACCGCGACGACCACAGCGGCACCGGAGTCGCGTTCAGCCGCGATCCCAACACCGGTGAGAACATCCCATTCGGCGAAGTCCTTTTCGGGCACCAAGGAGAAGACGTCGTCTCCGGCAGATCGACGACCCGCCCGCTGCGCGAACTCGCCGAGCGGGAGCCCGCGGTATGGGCGGAGCTGCTCGACGCCCTGAACCGGATCGAAGGACACTACCGCGACTCCTGCTACATCGAATTCACGTTCCAAGCCGGGGAGTTGTGGGTCCTTCAGGTCAGGCCCGGCCGGTTCGTCGGAGGTGCCGCGGTGCGCGTGGCCACCGAACTCGCCGAGGAGCGGGTCATCGGACGGCACGAAGCGCTGCTCAGGATCTCGCCGAGACATCTGCGGCAGGTCCGCACGCCACGTATAGCGTCCTCCGAGGAGGCCGACGTCTTCGCCCGGGGCCTCGGCGCCTGCCCCGGTGTCGCGGTCGGCCACGTGGCGACCACGGCGGACCGAGCGGTACGCATGGCCCAAGGCGGTGCCCTGGTCGTCCTGGTGCGCCCGGAGACCTCTCCCCATGACATGCACGGCCTCGCCGCCGCCACGGGAATCGTCACCGCTCGCGGCGGCCCGGCCAGCCACGCCGCGGTCGTCGCACGAGCCATGGAAAGGCCCGCGGTCGTGGGCATCGCCGGCCTGACCGTCGATGCCGGCAACGGCACCGTCACGGCCGGCGGGCGCACCATCGGCGACGGCACCCTCATCACCATCGACGGGACGAGTGGCGAGGTCGTCCTCGGCCGCCCCCGCATCGTCGCGAACGCGGCCGACGAGCACCTCCACCGACTGCTGGCATGGGCCGACGACACATCGGGGGACCACTCCCGACGCGGCGAATCCCAGCGGCTCGAAGCGGCCCATGCCGCACTGCGAGCGTCGGGCGCCTGATGGCCAGGAAGACATGGAAGACAAGGAAGGCCCTGAAAGGAGATCGGCGATGCCGACTCGGCACGTGTATCTGGTACGGCACGGAGCAGCGGACCCGTTCGGCGAGCTGACCGACATCGGGCAGTGGCAGTCGGAACTGCTCGGGCGGCGCCTGGCCGCACTTCCGATCGACGCGGTGTGGCATTCCCCCCTCCCCAGGGCGGTGCGGTGCGCGCAGATCGTCGGCAGGCACCTCCCGCACGCCGGCGTGCGGGAAGCAGCCGAGCTGATCGATCACGTACCGCACGTACCGGACGACGCGCCACCGGCGTGGGCGGCGTTCTTCGACGGGTACGACGCCGAGGAGGCCGCGGCGGGAGCACGCCTCGCCGATGCCCTCACCGACAGGTTCGCGCGCCCAGCCACATCCGAGACTCACGAGGTCCTGGTCACCCACGCCTATCAGGTGGCCTGGCTGATCCGGCACGCACTTGACGCGCCACCGGTGCGATGGCTGGGGCTGAACTGCGGGAACACTGCACTGACGGCGATCGAATACCGCGACGGAATGGCGCCGACGGTGCTGCTGTACAACGACATGGGCCACCTGCCGATCGATCTGCGGTGGACGGGGTTCGGGAGCGGCACACGGCCATGAGAGGCAGCGTGACCGCTGCGTTCGGCGGCCGGGCCACGGTAAAACCGCACGTCCATGGGCCACTTCGGGCGGCTGTCATCCGTCAGTATTCTCTGGTGCCGTGACCGATTCGACACCGCCGCCATGGGTTGACGACCTCTTCCCGTTCCCCACTCCGCCCGCGCTGCGCACGCTGATCGACATCGCCTGGCAGGACGCGTACGACTTCTACCGAGAAAACGAGAGCTTCGACTGCACCCTGCTGGAAATGCACTACGACTTCATGTTCGACCTGGCCAAGACTCCCCGGCCGCCCGATGGCTGCGACGCCTACCCGGAGATCGACAACCAGGATCGGCAGCTATTGGTGCCGCACTTCGCCACGCCGGAGTTCGTGCCCTTCGGGTCCCTCGGCGACGGCGGCTACATCGGCTGGCTGGTACCCGCGCCGGAACTCAGCAGGCTGGACCATCCGGTCGCGCTGGCCAACGGCCATGAACACGGCGTGACCCTGATCGGCACGGACACGCGTACCGGCCTGGAGTTCATGCTGTCACGGGCCCTACGACGGTGGCGCCAGGAGCCGGACACGGAGCCCCCGGCGGGGCGCGACCCAGACGTGTGGCTTGCCCAGAACCAGTGGCGCATCAACGCCCGCGTCAAAGACCGGCAACTTGCTGACCGGCTGGCCGCCGAACTCCGCGTACACCCGGACCCGGATCGAACCTTTCCCGGTTCACGGTGGAATGGCACGGCAGTCATGCAGGACACCGAGTTCGACATCGTGTTTGACGTACCGGAGGGGTGGCGGCACGAGCCCGGCGCGGACGGCATCGGCGTGCTCGCCCCAGCCGACGCCTACAACGATCGGGAGCCGGTGGTCTACGTCAGCTCGTGGGAGTCGTCGCTCGAACCAGCGCTGGCCGACGCTGAACGCCTGCTCGACACCGGACACCCGGCGACCGCGTTGCTCGGGCTCAAGGACATCTTCGTCAACGCGCCGAGCGGCCACTTCGCCGACCTCAAGCCGTTGTGGGCGCGAGCATACCGAGACCTCGGCCGGGCCGAATACGCGGAGCGCCTCGACCTGATGACGCCGATGTACCAGTGACCAGGGTCGGTGTTTTGTGCCGACGTTGTCGGCGTAGGCGGGTCAGTGGTGGTGGCTGTGTCGGCCGAGGGTCTCTACGGGGGTTGCGCCGGGGCGGGTCCACTGGGGCACGGGGCGGCTGGTCGGGCCCCAGGTTGCGTTCCCTTCCGCATCCGAGCGCCAGGACCAGCACGGGCTGCCGCCTTGGGGCCAGTCCTGGGGGTTGTCCTCCCATGCCTCGCCGCGGCCGTAGGGCGTCATGTCGAGCAGGCCCATGGACCCGTTGACCCGCTCGTTGCCGCGGCCGGTCGTGGAGTAGGTGAGGAACACGCGGTCGCCCTCGCGCAGGAAGCAGGTGAGGTAACCCATGTCGCCGCCGACCGGCACGTCCACGCCGCGCACCGAGTACCAGGGCTGGGTGTAGCCCATGAACGCGACGTAGGAGGCGACCTCGTCCCAGCGGCCCGTGGTCAGGACGGCGAACGAGACGCCGCGGGCGTTGAGGTAGGCGGCGTCTTTCAGGTGCCAGGCCGTGGTGGTGCAGCCCTCGCACTGCCCCTGGTGCGGGGCGCCGTCGTACCACATGTGCTTGTAGACCACGAGCTCGTCGCGGCCCTGGAACAGGTCCAGGAACGGGACCGGCCCGTCGGGTCCGACGACCTCGACCGTCCCGTCGAGCTCCACCATCGGCAGCCGGCGGCGGGCCGCGGCGAGGGCGTCGCCCTCCCGGGTGTGGGCCTTCTCGCGGACCAGAAGCTCATCACGGGCGGCCTGCCAGGTGGCCAGGTCAACGACAGGCGGACGGCCGGGCAGCGCGGTGGTCGGTTCGTTTGGCGTGGTCGTCATGGTGTCCTCCGTGGTGTCTCGTGCCGGGCAGCGTCGTACGACGCCCTACAACGGTCACCAGAACAGACTCCCGACCCGGCCGAAACTCATCGCGGCACGGGGCACCCTCGACCGAGCCTGCCCAGACCACGCCGAGCTGAACAGTGCCCTGACCGCGGCTGGCGGCAGGCAGCGCTGACCGGCGCGGCAGGCCGGTCGCCGATGCCGGCCCGCCGCGCCGGTGGCTTCAGCGGCGTGCTCTGGCGGTCTTGCGGCGGCGGATGACCACGGTCGTGATGACAGCGGCCTTGACTGCGACAATGCCGAGGATGGTGACGAGTGCCCAGCTTGGCCAGGAGGAGCCCACCAGGGCGCGACCGGCTCCAAGGTGCACGGCCAGGACCAGCAGGGCGACGGCGGACAAGGCGACCGTCTTGCCGTGGGCGCGGAGCGGTGACCGTGCGGCGGGTGGCCCGCCCGCCACGCCGTCGTCGGGTGCTGTCCCCGGAGCCTGGGAACGATGCCAGGTCACGTGCAGGTTGTCGCGTCTGCCGATCTTCTCGATGCGTGCGGCGGTGCCGTCTTGGATGCGCCGCAGGTGTTCCTCGTCGTCGGCCCGGGCGCGGAGTGTCAGCCCTTCGGGACTGGCTTCCAGAGTGCACTGACCGAAGCCGAAGTCGAGGGTGCCGCAGGTGTCGGACCATTCCACGCGCCGGATCCGGGGAGGAGCCCCGCCGGCTGTGTGGGCGCGCGGGCGGTGGCCGGGGATTCCGGTCATCTGGCTGCCGTGTCGGCAGAGTTGGACGAGGTACCGGCTCGCCCGGTCGGTTGGAATGTCGGCTTGTGCGGTCAGCATGTCGCTGCCCACGTCGGGGGCCGCTTCCTCTGTCAGTGCCGCAGGGTGGGCATCGTTGACCTCAAAGGACCCGGTCGTGGTGGCGGAGACCAACCAGCCCTGGAGGCCGTCGGGGTGGCGGGTCGAGGCGATGGTGGCCGGTTCGATGGAGTCGATGCACCATCCCTCGGCGAAAGCAAGACGGATCTCCTGCGCCGTGAGCTTGTGCGGGCGTCCCAGTTCGCCCGGCTGCCGGTCGCTGAAGCCGAGCATGAAATAGCGGCCGCCCGGCCTCAGGACGGTGCGCAGGCCGCGGAGGTAGGCGGCACGGTCCTCCCTGGTGAAGCTGTGGAAGACCAGGGAGTCGAGCACGGTGTCGAAGGAACCTGAAAGGTCTGCCAGCTCTCGGGCGTCGTGGCGCAGGAAGCGGGCGGTCAGCCCGCGTGACCTTGCCTTGCCCTGCGCGGTGTGCAGGGCGTTTGTGGCGAGGTCGATGCCGGTGGCATCAAGCCCCAGACCAGCCGCGAGCAGGGTGTGCTCACCAGTGCCACAGCCGACGTCCAGCACCCGGCCCCGGATGGCCCCCGCGTCAGCGAGGGCCTGAAGCGCCGGCTGGGGCCGGCCGATGTCCCACGGCGGCCTGCTGCTGTACAGCTCCTCCAGTGCCCCCGAAGCTCCGGCAGAAGCTCCAGCAGAAGCCCTGGCATGGGAATGCGGCTGTGTCATGGCGACGCCCTTTCCGTCTTGGCTGCCCCGCAACGCTCACCCAGCTTTTTCGATACACATTGTCGCTGTCAAGTCGAATCGTCACACTGGCGGCGCGGCGTACAATGGCGTGGTGCCGAAGCTGTGGAACGAGACGATCGAGGAGCATCGCAACGCGGTGCGCGAAGCGATCCTGCGCACCACCTGGTCACTGGCCACCGAGCAGGGACCCATGTCGGTGACCATGTCGCAGATCGCCGAGAAGGTCGGCATCGGCCGGGCCACGCTCTACAAGTACTTCCCCGACGTCGAGTCGATCCTGAGCGCATTCCACGAAGGCCATATCGCAAGCCACATCGAACAGCTTCACCAACTCCGCGAGAGCCTCCCCGACCCCGGCGAACGGGTTCGGGCGGTCCTCGAGCGCTACGCGCTCATCTCCTACCGCCGGCGCAGCCAGGGCACAGAGGAACTCTCAGCGCTGCTCCACCGCGGCGAAGCGATCGTCCAGGCACAGCGCCACCTCAGCCGGCTCTTCGAAGATGTGATTGCGCAAGCCGCCGCCGCCAGAGCACTCCGGGACGACATCGCCCCCCGAGAACTCGCCGCCTACTGCCTCCACTCACTCACAGCCGCCGCCGATCTGCCCTCGGAGGCCGCGGTCCACCGGCTCGTCAGCCTCACGCTCCAAGGGATGCAAACCCCGGCGTGACCGTCGATATCGACTCCGCAGGTGACCCGCCGGGCGTCCTCGGCGACGGAACAGCACAGTTCAGGGCCGCAGGTCAGTGCAGGTCCACCCAGAACGCGTGACGGTAGTCGGCGGGGCAGGTGAAGATGCGCAAGTCTCCCCACCGGCCGACGACAACCCCTGTCTCGTCGTCGCTGGCCACGGTGAACAGGAGTGTCATTGCCGTGCCGCAGTCACCGCAGGCAAAGACTGTGGGCTGGTTCAGGTGCCAGGTCGGCCAGCCGCCGAGTTTCCAGCCGGCGAGGCGGGTGATGGCGTCACCGCCGTCGCCGGTCTCGCGGACCAGTTCCTCGAGCCGCGGACGGAGCTCTGCCGGCAGCTCCTCACGGAAAGGGAAGTCGGTCACGCGCTCGGCGGTGATGGCGCACGCCTGCGGCAGGCAGCCGTCCTCCTCATACCGCGAGGGTGGCGGCGGAGTCGTCAATGGGTCGACCACGTCAGCGGCCCGACGCCAGCGCACCTCAAGCACAGGGCTGACATCGGCCTGCGGGGCCGGCGGATCCCAGTGTTCATTGGGACACCAAAGGATCTGCAAGAGGTCGATACCGGCGGGCCACCAGGGTCCCGGCGCGTCGCGACGGAAGATCTGGGCGACCGGCACCATGGCCGTGGCAGGCACGCCGGCAAGGCTGTTCTCGTCGGGCAAGGAGCATTCGGGCCACCGTTCGCCACTCGGCCATAGCAGTGGTCCGCCGATAGAACTGTTCCGGCAGTCCGGCTCAGCGCGCTCGGGATGGAATATGACCGCGTCGCGCGCGTGGGGAGCAAGTTCGGGAAGCACGGCGAGTATCGCTTCGACCGGCGGTCTGGGAGTGCTGGTCATCATGCCTTCCGGTCAGCTGGTCGTAGATTGCTCGCAGCGTATAGGCCGGCTGTGACAGTGCAGGGATCCCGTTGACGGATTATGGCTCTGCCATGATCCAACCGGCAGCGCCTATGCTTCCGCCGTGAACGACACCACGCATGGCATACGGATCAGACCAGGCAGCCTGGCCGACGCACCCGCTATTCTGGACATGCTCGACGCCGCGGTGGCATGGATGAACGAGCGCGGAAACACCGAACAGTGGGGCACGACACCGTATTCGCAGAAACCCGGCGGGGTGGCGCGCGTCGAGCGATACACCACCGAGAACGCCCCTTACATCGCGGAGTTGAACGGAGCACCTGTCGGAGCCCTGGTGCTGGGCTCGGGTCCCAACCCGCAGGTGCCGATCGTGTCAGCCGGAGAGCCCGAGCGGTACGTCCGGCTGCTGGTGTCCGACCGTCGCCACGCCGGTCTGGGCATCGGGGCGGCGCTGTTGGTCCATGCCGCCGAGGAAACCCGGCGGGCCGGTGTGGGGCTGCTGCGGGTCGACTGCTGGGCCGGCGGCGGAGGCGAACTGGTCGCGTTCTACGAACGCAACGGCTTCGCCCCTACCGACCGCTTCCTGTCCGGGAACTGGCCGGGACAGGTGCTGGCCCGACGGGTCGACTGACAGCGCGGGCAGGTCAGCGGACGACAGGCTTCCCGGTCCCCACCGGTCGGCGGTGCCGCCCGTGTCGCACGGCAGCACTCCTGCCGGCACCAGCGACCAGGATCCGGACGACCCCATGCTGCGCATCATGATGCGCACCGCCGAAGCCGAGCGGAAAGGCCGGCTCGGTGAGGCCGAAGGACTTCAAGTCAGCCTCAGGGACTCCAAGTCAGCCTCGCCGACGCCCGACCCGACCCCTTGTCCGTGGACTCGAGCCCAGTCGTGGGGTAGATCTGGAAGAATCCTGCACGGGACCGTCTGACGCGCGCGGGGACGCCAGAGAAGGCACGGGGGCTGCTGTGGTACCGATCATCATCGTCCTGATCATCCTGGTAGTGCTCGTCTTCATCACACTCATCAAGACGATCCAGGTCATCCCGCAGGCGAGCGCCGCCATCGTCGAGCGCTTCGGCCGCTACACCCGCACCCTCAACGCGGGCCTCAACATCGTCGTGCCGTTCATCGACTCGATCCGCAACCGCGTCGACCTGCGTGAGCAGGTCGTGCCGTTCCCGCCGCAGCCGGTGACCACCCAGGACAACCTGGTCGTGAGCACCGACACCGTCATCTACTACCAGGTGACCGACGCCCGCGCCGCCACCTACGAGGTCGCCAGCTACATCCAGGCGATCGAGCAGCTGACCGTCACCACCCTGCGGAACATCATCGGTGGCATGGACCTGGAGCGCACCCTGACCTCCCGCGAGGAGATCAACGCGGCGCTGCGCGGTGTGCTCGACGAGGCCACCGGCAAGTGGGGCATCCGCGTCAACCGCGCCGAACTCAAAGCCATCGAGCCACCCACCTCCATCCAGGGCTCGGTGGAGAGGCAGATGCGCGCCGACCGCGACAAGCGCGCCGCGATCCTCCAGGCCGAAGGCGAGAAGCAGGCCGCGCTGCTGAAAGCGGAGACCGAACGCGAAGTGGCCGCCATCCTCGCCGGCGGAAGCGGAGCGACGCGAAGCACACCGCAGTCGCCCGTCCGGGCCAGTCCCGTCCCCGGACACCAGCCACTGCTGCAGGACGATCCCCGCCGTATCGGCCGTTACCACCTGACGGCTCGGTTGGGCCAAGGAGGGATGGGGACGGTCTATCTGGGCCGGTCTCCCGGGCAGCGCCTGGTCGCGGTCAAAGCCATCCGGCCGGAGTTCGCCGCGGACCCCACGTTCCGGGAACGCTTCGCCCGCGAGATCGATGCCGCACGCCGTGTCGGCGGATTCCACACCGCGCCGGTGGTCGACGCCGACTCCCGCGGCGACCTGCCCTGGCTGGCCACCGAGTACATCCCAGGCCCTTCACTCCACGACGTCCTCAGACAGCAGGGTGCCCTGCCCACGAGGACCCTTCTCACTCTCGCCGTCGGCATCGCCGAGGCACTTGAGGGCATCCATGCCTGCGGCATCATCCACCGTGACCTCAAACCAAGCAACATCATCGTTTCCAGTACGGGCCCTCGCGTCATCGACTTCGGCATCGCCCGAGCCCTCGACAGCACCGCACTCACCCGTACCAACCATGTCGTCGGCACACAGGGGTTCCTCGCCCCGGAACAGCTCACTGGCACATCGATCACGCCCGCCGCGGACCTCTACGCCTTTGGCATGGTGCTGTGCCACGCCGCCGGAGCCACGCCGCTCACAGACGGCGAATCCCTGGAGTCAGCCCTCAGTCTGCTGCCGGCTCGCTTCGTCGGCATTATCACCCGATGCCTCGACCACAACCCGAACGGCCGTCCAACGCCCACCGAGGTACTCGAGCAACTCTCCCAGAACGACTCCCCGACCGAAGACTGGCTACCGCCTCCCGTACGCACGATGGTCGACCTGCACAACGCCCCAACCGCCGCGGAGCCCGGCCGCTGAGCGGACGAGTGAGGCAACCTCCTGGGAGCGGCTGCTCTGCGGCCATGCGATCACCGTGGTGACTTTCGGCGCGTCGACGACGGGCACCGCGACGTGTTCGGGCCACTGCCAGGCACGGCTGGAGGCAGGGATGACGAGCAGCGTTTTGCCGAGCGCCACGAGCTGAGCGAGCTGCGACTGGGTGTGCACCTCCGGTCCGGGCCCGTCCGGGTAGGACCCGTCGAGCCGGGGCCACCGAGCGATCGGCAAGTGCGGCACGTTGCTGACATCCGCCAGCGTGAGCTGATGACATGACGCGAGCGGATGCCCCGCGGGAAGGATCGCGACCTGGCCTTCGACGCGGAGGTCTTCGGTGTCGAACCCGGCGAGGTCGTCGAACGGGCGATGCATGAGTGCCACGTCGGCCTGCCCGTCGCGGAGCAGCCGTGCCTGCTCGCCGACCTCGCACAGGAGGACCTCAATCGGTGCCGCCCCGGGTTCGCTCGCAAGCGTGTCGAGGAGCCGTCGCAGCAGTTCATGGGACGCCCCGGTCTTCGTCGCGAGCACCAGCGGCCGCTTCGGATCTCCGGCACGCCGCGTCCGACGCGCAGCGGCCGCGACCGCGTCAAGGGCCACTCTGGCCTCCCGAAGTAGCACCCTGCCGGCCTCGGTGAGCGCCGCGCCACGACGGTCCCGGTCAAGGAGCTGGACTCCGAGCCGCTGCTCCAGCCGGCGGATCGCGCGCGAGAGCGGCGGTTGTGCGATCCCGAGCCGACCGGCGGCGCGTCCAAAGTGCAATTCCTCGGCGACGGCGACGAAGTACCGGAGCTCGCGGGTCTCGAGATCGTCCACGCGAGCAGCCTACTGCCTGATACCTGGTGAGTATCACAGCGGACTGATCCGGTATTGGACGATCTGTGCGCGGCTCGCCGAGCATGGATCGAGTGAACGACACGAAGACCGCGCTGGTCACCGGCGCGAACAAGGGAATCGGTTTCGCCATCGCACAGGGTCTCGGGGCGATCGGCTTCACGGTCGCGGTGGGGGCTCGCGACGACGCCAGGCGTGAGGAGGCCGTCGAGCACCTGCGTGCCGCGGGCGTCGACGCGTTCGGGATCGCCCTGGACGTCACCTCCGACGACAGCGTCGCCGCCGCGGCGGCGGCGATCGAGCAGACGGCAGGGCGGCTCGACGTGCTCGTCAACAACGCGGGCATCTCTGGCCGGACCGACGGTGGCGCGCAGGATCCGACGACGCTCGACCTCGACGTCGTCCGCACCGTCCTTGACACAAACGTGTTCGGGGCCGTTCGGGTGACGAACGCGATGCTGCCGCTGCTCCGCCGCGCAAAGTCGCCGCGCATCGTCAACATGTCGAGCAATATGGGCTCGCTGACGCTGCGGACCGGCCCGATCATGGCCGCGTACGCACCGTCGAAGTCAATGCTCAACAGCGTCACGGCACAGTACGCCCGCCGACTCGCCGATACGAATGTCATCGTGAACGCCTGCTGCCCCGGCTACGTGGCGACCGACTTCACCGGCTTCAACGCGCCACGGACGCCCGAGCAAGGTGCCGCGATCGCAATCCGGCTCGCCACCCTGCCGGATGACGGACCGCGCGGCGGCTTCTTCGACGACGAGGGCGTCATCCCCTGGTGACCCCGGACGGGCGCGGTCCGGCCGGCGGTTGCCTCGCCGCCCAGGTATGGCGTATCGACCGTACCGGGCGGGCCGCCGCCACCAACCTCGCTGCTAACCTCTGCGGAGTCAAAGTGACTCAGGGGGAAAGTCCGTGTTCACGTCGCTTGCCACGGAGTGGCCGTGGCTCTTGGCTGTCATAGCCCTCGTAATCCACTGCTCCGCCATGGCCAAATGGGTGCCAATTCAGAGATTCTGGACGGTGTACCCCTTCATATGGGTGTTGTGTGGTGTCGGAGCAGTGGCTATCGGTTCGTCGCAGGGCTTCGCCCTGACCGACATGCTCGTCCTGTGTTCATTCGCCCTCGTCGGGCTGACAATCGGCCTGTTCCCGACGCGCAAGCTGTTTGTGATGTGGGCCCACGAGATCAACAGGGGCGAGCAACAGGAAAGTTACCCCTATCCGCGCTCGCACCTCGCATTCTGCGGCGTCTCCGTGATCGTCGCGGTGCTCGCCGCGTTTCTGCTGGTGCAGTGAGACGCCGCGATCGGTTGAGCGACGCTCGACGTCACACTCATCAAACGGCTTCACCCAGGGCAGAACGCCGCTCCCTTCCCCCGGCGCCCCGGATCCCTAGGCTGAAGGGGTGAGCACTCATGCGCCGAACGAAGCCCGCGTCATCCCCCTGCGCCCGCAGACCCCGCCGCCCGGTTCCGGCGGGGCGCCCCGCGCCCCGCAGCGACCGGCGGGAGCCCCACAGACTCCCGCGCCGAGGGAGCCCCTGTGGCGCGACCTCGTCGGCGATGTACTGCGTCGCGAGCGGCTCGCCCAGGAGCGTACGTTGAAGGACGTCGCGGAGGCGGCCCGGATCTCGATGCCGTACCTGTCGGAGCTGGAGCGCGGACGCAAGGAGGGCTCCTCCGAGGTGCTCGCGGCCGCCGCCCAGGCCCTCGGGCTCGGCCTCGCCGACCTGCTCTCGCTCACCCAGGACGAGTTGGCCCGGTACGCCCGGAGCCGGGTGGGCCGGGGCCGCACGTCGCCCACGGCGCAGTACGACGGCCTCTGCCTCGTCGCCTGACCGAACCGACGGCCGGTACGACGGGGCGCGCCACCGCCGTACCGGCCGGCTCGGCGGCCTTCGGCCACGGCCGCGCGGGGTCAGACGAACGCGAGCCGTCGGCTCAGCACCTCGTCGGCGAGCCCGTAGGCGACGGCCTCCTCGGCAGTGAGCACCTTGTCCCGGTCCATGTCCGCGCGCAGCGTCGCCACGTCGTGATGCGTGTGCCGGGACAGGACCTCCTCCACCTGCGAGCGGATGCGGACCATCTCCTTGGCCGCGAGGCTGAGGTCGGAGACCGTCCCCTGCCGGCCGCCGCTGGCCGGCTGGCCGAGCAGCACCCGCGCGTGCTGGAGCACGAACCGTCGCCCGGGATCTCCGCCGGCCAGCAGCACCGCCGCCGTCGACGCCGCCTGACCGACGCAGAACGTGGAGATCGGCGCTTGCACGAACGTCATCGTGTCGTAGATCGCCATCAGCGAAGTGAACGATCCGCCGGGCGAGTTGAGATAGATCGAGATCTCGCGCTCCGGGTTCGCCGACTCCAGATGCAGGAGTTGCGCGATGACCACATTGGCGACCCCGTCGTCGATCTCGGTGCCGAGGAAGATGATCCGCTCGTTCAGCAGCCTGCTGAAGACGTCGTAGGACCGCTCGCCCTGCGCGGTCCGCTCGATGACGTAGGGAACCGTGTACGACCCCATGTCACAACCCCATCCGTCGGCGCGACGCGGCCGGGCGGATGTCGGCGACCGACTCCACCACCCGGTCCACGATCCCGTACTCCCTGGCCTGCTCGGCCGTGAACCAGCGGTCCCGGTCGCCGTCCCGCGCGATCGTCTCCTCGCTCTGCCCGGTGTGCTCGGCGGTGATCCGTTCGATGGCCTCCTTGGTGAACTGGAGGTTCTCCGCCTGGATCTCGATGTCCGCGGCGGTGCCACCAATGCCCGCTGAGGGCTGGTGCATCATGATCCGCGCATTCGGCAGCGCGAACCGCTTGCCGGGTGTCCCCACCGTGAGCAGGAACTGGCCCATGCTGGCGGCGAACCCCATCGCCAGCGTCGAGACGTCGTTCGGGATGAGCCGCATGGTGTCGTAGATGGCGAGACCCGCGGTGACCGACCCGCCGGGGCTGTTGATGTACAGGCTGATGTCGGTGCGCGGGTCCTCCGCCGACAGCAGCAGCAGTTGCGCGCACACCCGGTTGGCCGACACGTCGTCGACCTGTGTGCCGAGGAGGACGATCCGCTGGGCGAGCAGTTGTGCCGCGAGATGGTCGTCGAAGCGGCTGGGCGGTGTGTCGCCCTCCTCCGCGCGGGGCGGAAGCGTGGTGAGTGAAGTCAT

Protein sequences of DBSCAN-SWA_1

>NC_016582|19705:83640|81885_82317_+|WP_043485901.1|DBSCAN-SWA
MSTHAPNEARVIPLRPQTPPPGSGGAPRAPQRPAGAPQTPAPREPLWRDLVGDVLRRERLAQERTLKDVAEAARISMPYLSELERGRKEGSSEVLAAAAQALGLGLADLLSLTQDELARYARSRVGRGRTSPTAQYDGLCLVA
>NC_016582|19705:83640|34487_35120_-|WP_014172636.1|DBSCAN-SWA
MTSVAPYSPDETALLLVDPYNDFLSEGGKLWPRAKEVAEGVGLLDHMRTMLATARSQGFRVFIVPHHQTTPNDYITWDHLSPTQQRIVTQQTFAEGSWGAEWHPDLHPREDELVMRQHWASSGFANTDLDFMLKQHHIRKIVLIGMRANTCVDTTARFGQELGYHVTLIRDAIASFSWEEMTATFELNAPLYAHAILTTDEFVDVVGETP
>NC_016582|19705:83640|83001_83640_-|WP_014172691.1|protease|DBSCAN-SWA
MTSLTTLPPRAEEGDTPPSRFDDHLAAQLLAQRIVLLGTQVDDVSANRVCAQLLLLSAEDPRTDISLYINSPGGSVTAGLAIYDTMRLIPNDVSTLAMGFAASMGQFLLTVGTPGKRFALPNARIMMHQPSAGIGGTAADIEIQAENLQFTKEAIERITAEHTGQSEETIARDGDRDRWFTAEQAREYGIVDRVVESVADIRPAASRRRMGL
>NC_016582|19705:83640|45988_47506_+|WP_014172650.1|DBSCAN-SWA
MHHILCGLAANPALSSELVDRLISIADDDIAAGLACRADLSRAQAVALAERVDESAVRLAYEGRLTAADIDPAVWPDAALALLDQGVGRPEWARRLAADPVRERREQLAACRGLPSDVVDTLAADPDVRVVAELALWTTPDVAARLAAHPHAEVRRAVASNEATPPAALVALVTGEGLPAARHCLVCDREETPFIHDPQCLRPDCDLLPGASCDGSHESTVHAMREAALRNPATPVEAVVGFVDYPSMQLRWALAARQDLPQQACARLASDPTPGVRADVAENPAIDDALIRALAGDRDPDVRRRLAHHPRVPLDVLTHLARTTKIGATLLPRIAASSPTEVEELATSPDPATRMLVAQRRDLPPEIRDRLADDPDAKVVKALAPHPGLTEAQLRTMVDRHGVRVLAKVAANPDAPPALLEDLLRHEPAAQKVFREVARHRGATASALLACLTDKRARPVAAGHPALPPPVIAELLADTDWQVAEAAAANPSLPLAVISDLVGRQ
>NC_016582|19705:83640|50792_51419_+|WP_014172654.1|DBSCAN-SWA
MTTTDAVAFWDGVYAARPAAGNPQPNARLTETVTGLPAGDALDLGCGDGGDALWLAGQGWQVTAADISAVAVERLAALARAHGLGDRVTAVRHDLHTSFPPGGFDLICAHYLHTPCDLDRATVLRSAAHALRPGGRLLVVDHGSAAPWSWNQDPDTHYPSPQEVAAGIDLAPETWTVERADAPRRIATGPGGRTAEVIDHVLLIRRTA
>NC_016582|19705:83640|72155_73145_+|WP_014172679.1|DBSCAN-SWA
MTDSTPPPWVDDLFPFPTPPALRTLIDIAWQDAYDFYRENESFDCTLLEMHYDFMFDLAKTPRPPDGCDAYPEIDNQDRQLLVPHFATPEFVPFGSLGDGGYIGWLVPAPELSRLDHPVALANGHEHGVTLIGTDTRTGLEFMLSRALRRWRQEPDTEPPAGRDPDVWLAQNQWRINARVKDRQLADRLAAELRVHPDPDRTFPGSRWNGTAVMQDTEFDIVFDVPEGWRHEPGADGIGVLAPADAYNDREPVVYVSSWESSLEPALADAERLLDTGHPATALLGLKDIFVNAPSGHFADLKPLWARAYRDLGRAEYAERLDLMTPMYQ
>NC_016582|19705:83640|62170_63088_+|WP_043488429.1|DBSCAN-SWA
MKTSVTFPSNNLAVAGILFTPDDHIDGRLPAIVISHPGGGVKEQSPSIYAERLAREGFAALVFDAAYQGESEGEPRGMENPFQRAEDIKSAVTYLTTRDDIAPDRIGALGICASGGYVPYAAQTDHRIKGIATVSAVDLGSVFREGLGRTQDLAVLKAMLDRSGALRTEEARGAAPQLEAWIPDNAEELLETATRQFRETFEYYRTPRGYHPRAVQGWVLRSIDLIAQYDSYAMIRLISPRPLLMIAGSEAESAYFSREAIEKAAEPKELVVIDGATHIDLYDKDEYVTPAVAKLTEFFGKHLAG
>NC_016582|19705:83640|55056_55296_+|WP_106436499.1|DBSCAN-SWA
MAKGLPKRVVVEVERLAGQLVDLAEMGIDVTAVGDGPRPGVAGGVRRLSVLEDGFMLVLPLPRLRLVAVTYICPPFADL
>NC_016582|19705:83640|36695_37079_+|WP_014172640.1|DBSCAN-SWA
MVTKQLLRGLPENADLRRADSLAREIFSDVANKWALLIIEALGERTLRFSELRNEIEGISHKMLTQNLRMLERNGLVNRTVHPTVPPRVEYTLTEPGRALRTTVDAICGWTHQYLGHIEDARRRFGD
>NC_016582|19705:83640|71467_72055_+|WP_043485896.1|DBSCAN-SWA
MPTRHVYLVRHGAADPFGELTDIGQWQSELLGRRLAALPIDAVWHSPLPRAVRCAQIVGRHLPHAGVREAAELIDHVPHVPDDAPPAWAAFFDGYDAEEAAAGARLADALTDRFARPATSETHEVLVTHAYQVAWLIRHALDAPPVRWLGLNCGNTALTAIEYRDGMAPTVLLYNDMGHLPIDLRWTGFGSGTRP
>NC_016582|19705:83640|79550_80450_-|WP_014172686.1|DBSCAN-SWA
MDDLETRELRYFVAVAEELHFGRAAGRLGIAQPPLSRAIRRLEQRLGVQLLDRDRRGAALTEAGRVLLREARVALDAVAAAARRTRRAGDPKRPLVLATKTGASHELLRRLLDTLASEPGAAPIEVLLCEVGEQARLLRDGQADVALMHRPFDDLAGFDTEDLRVEGQVAILPAGHPLASCHQLTLADVSNVPHLPIARWPRLDGSYPDGPGPEVHTQSQLAQLVALGKTLLVIPASSRAWQWPEHVAVPVVDAPKVTTVIAWPQSSRSQEVASLVRSAAGLRGGWGVVQVDHRAYGRR
>NC_016582|19705:83640|65647_66004_+|WP_014172671.1|DBSCAN-SWA
MMRFVLVIHQGTYPLPGTPQAELVSEEDRKAAYADWAAIGKMENVTGAPPMGLPKDATTVRVEDGSAVATEGPFDNTSVGGFLVVEAEDLDSAIAIASRVPQARLGGAVEVRPSAKYW
>NC_016582|19705:83640|54631_55003_+|WP_014172658.1|DBSCAN-SWA
MSEAAADGHRPLIPQPKTTAEDLRAALVQIAPNQVAAFDAERTTAVEAARSQVDAAPMRRFLRRWALAVAIERVPARAARLSELEARAGQVEDLAEGRAIAAEVAAIHAQAAAEAGVDGRTAE
>NC_016582|19705:83640|20146_20485_+|WP_014172622.1|DBSCAN-SWA
MTRYLISFDDGAMTFPEEELPEVAEASLEVVRKARDAAVWVFGGGLERQQASVVSTDGTVTNGPYPETKAVLGGFAIIDVPSREDALEWAAKIAAACRCAQEVREIMADPTV
>NC_016582|19705:83640|69109_69736_+|WP_014172676.1|DBSCAN-SWA
MTRSETHTTNANLLVLHALRCAGAAGPARLHAFTGLDESDVESELIDLGAEGLVTRMSGDMPCWLLTDTGRAADAERITDELTSANARGAVEAAFDRFLVLNPELLDLCAAWQLRTVDGIMNANDHSDPVYDSRVLDRFADLDRRAAPVCAELSAALPRFGRYRDRLAGALDRAASGALEYVTDSTASYHTVWAELHEDLLATLGMRR
>NC_016582|19705:83640|82397_83000_-|WP_014172690.1|protease|DBSCAN-SWA
MGSYTVPYVIERTAQGERSYDVFSRLLNERIIFLGTEIDDGVANVVIAQLLHLESANPEREISIYLNSPGGSFTSLMAIYDTMTFVQAPISTFCVGQAASTAAVLLAGGDPGRRFVLQHARVLLGQPASGGRQGTVSDLSLAAKEMVRIRSQVEEVLSRHTHHDVATLRADMDRDKVLTAEEAVAYGLADEVLSRRLAFV
>NC_016582|19705:83640|74196_75510_-|WP_078610256.1|DBSCAN-SWA
MTQPHSHARASAGASAGASGALEELYSSRPPWDIGRPQPALQALADAGAIRGRVLDVGCGTGEHTLLAAGLGLDATGIDLATNALHTAQGKARSRGLTARFLRHDARELADLSGSFDTVLDSLVFHSFTREDRAAYLRGLRTVLRPGGRYFMLGFSDRQPGELGRPHKLTAQEIRLAFAEGWCIDSIEPATIASTRHPDGLQGWLVSATTTGSFEVNDAHPAALTEEAAPDVGSDMLTAQADIPTDRASRYLVQLCRHGSQMTGIPGHRPRAHTAGGAPPRIRRVEWSDTCGTLDFGFGQCTLEASPEGLTLRARADDEEHLRRIQDGTAARIEKIGRRDNLHVTWHRSQAPGTAPDDGVAGGPPAARSPLRAHGKTVALSAVALLVLAVHLGAGRALVGSSWPSWALVTILGIVAVKAAVITTVVIRRRKTARARR
>NC_016582|19705:83640|77187_77718_+|WP_014172684.1|DBSCAN-SWA
MNDTTHGIRIRPGSLADAPAILDMLDAAVAWMNERGNTEQWGTTPYSQKPGGVARVERYTTENAPYIAELNGAPVGALVLGSGPNPQVPIVSAGEPERYVRLLVSDRRHAGLGIGAALLVHAAEETRRAGVGLLRVDCWAGGGGELVAFYERNGFAPTDRFLSGNWPGQVLARRVD
>NC_016582|19705:83640|76274_77063_-|WP_043485898.1|DBSCAN-SWA
MTSTPRPPVEAILAVLPELAPHARDAVIFHPERAEPDCRNSSIGGPLLWPSGERWPECSLPDENSLAGVPATAMVPVAQIFRRDAPGPWWPAGIDLLQILWCPNEHWDPPAPQADVSPVLEVRWRRAADVVDPLTTPPPPSRYEEDGCLPQACAITAERVTDFPFREELPAELRPRLEELVRETGDGGDAITRLAGWKLGGWPTWHLNQPTVFACGDCGTAMTLLFTVASDDETGVVVGRWGDLRIFTCPADYRHAFWVDLH
>NC_016582|19705:83640|64295_64931_+|WP_014172670.1|DBSCAN-SWA
MVDTSTDNTNLKSQYAAQITADLERNSTEHERLSTEISALQRQLSVLENNRVLLLSMRQTLGGGTAADVPGNTGVSSSEDESSAARESATLPAARKPAKKTNTATGKRKGAESDGSRPKRVRETGVPTLRDLIRDDLIQHGEPRSAAEVTTALTQALPDREIKATVVRSTLESLVAKGQVHRTKQQKSVFYSVTAPDTAAGTSEPSTASAS
>NC_016582|19705:83640|24978_27909_-|WP_014172629.1|DBSCAN-SWA
MVDGSSGVDSGYQAHRAAFAVFAEQLRKGDRRAALAAAHAVHDQVLAARHLNLRGVALNCVGLAQFELGEFAAAVESHQRAKDLSRRSDVRGFAALRANLARIAAGESVAYPQVWEADSAPGQLAALARSEHPHLAPAAGVELGRLLCGEQHFLAAIRAYWAVVDSGHPWFRPRAAAPLAKLLREAGDHEGASRVLDYASPEADAPDLVDLALAPLDDPEEPPFWLAPVRSGLGHYRAGDLTAARAELRAVAAGDWRHAAHQAGTVLAGIELRHGDLTAARQLLGDLAETADFTHGPRAAVALAILDAAEAAPPDTTTTVGPVSALARYLTRDQDVLADLEALAQGRHPLAGVFAALLGDLLDDGRPGSGAAHWQDRAVQSKDRLAVGYTAYLTATNLTMWDNTERVVDALAEACESAPAVLPWAAVRLGEANLADSYGSGDSQSFFQGVLDTGHRALVPRAAAGLFNSSPADSWSAEERYELAEELLTGDLPAEAVPPLAWLAAEKLITYEDDLDGGREALERIPESDPEFGAPALAVRLLLDEEADGMRAVFERLARWDDRSLEMASECCMSVLWKLPDESAVTRRALLVLADLGDQSAPLAHKVWERLIKVCQIQHDLDGELAAREASNLRLDRHPGSGVLEAARRFYLDGDLDQAVELYQRVSTEEFPEARSKAAVDLGVLLRHQGRHEEAQELPAADVHPQYCFRLGTDLEGAGRIDEAILAWELIADTDDITWAVRAHYYLGKAHADRGEFDAAIAAYQRAGATEDSSFRGRAWYELGCLYQDQGNLALAKEAQQRGADVAARLGKDGETVLGGCKLRLAQLSTLSGETEDARRRYLDMVDNADRGTAAMGAMMLGGDAKDRRDVAEAQRWYQWVIDSGDLFQRQLALAHLGELYYWVGDRDQSREFYQRTLDSTRSNPDLVAEAAYRLGEMAGEDGDTDQAVRYLERARDTGDATFGPQASQLLGRLTG
>NC_016582|19705:83640|34039_34285_-|WP_014172635.1|DBSCAN-SWA
MPERVGNVTRERYEQIVAAARQLVAQITRTQFTLGDKTLEIEPMRPVGGAMPNGTEDLFTVEESFALFAEDIEVAPSTVKD
>NC_016582|19705:83640|54209_54635_+|WP_014172657.1|DBSCAN-SWA
MRADDSTARPGRLVWMDTDLWKQQVKRRAEDDGLARARSRVLEALLTAYAEGSLDAPVPAGSTFGTAERGGCRVYLAESVCERAETRWKRQEQARRGGVPGFGLLCEVLLREYAEGRVELRITAAPAGSTGSTGNTGSMAA
>NC_016582|19705:83640|24141_24480_-|WP_014172628.1|DBSCAN-SWA
MSINRRAAVVAASLGITTGGLFLAAAPASASAQDIWTCNPPQYMTGSGGHAGASLQCFGTSWDDAFNVAVTCKRWDNGYEYRHDGPKVQTGQVSTVWCDLNAGIVHLAYVAW
>NC_016582|19705:83640|23041_23524_+|WP_014172627.1|DBSCAN-SWA
MPLEGEYEPSPAQWVREQVELYESSGGTQGTTLWDTGLPVVIVTMRGAKSGRIRKIPLMRVEHEGRYAAVASKAGFPRHPVWYFNLKADPQVDLQDGPKRQGMMARELTGDEKAQWWERAVAAYPPYAEYQEKTNRVIPVFVLEPEHLAGPAKAPAPTRN
>NC_016582|19705:83640|36190_36592_-|WP_014172639.1|DBSCAN-SWA
MATIDVFNHNVPAESDFGYSQAIKSGDLIHVSGQLSLDEAGEFLYADDFDAQLKQTYVNLDKVLDHYGVTRNQVVSQTLYVVNLRQNAAATAEGNLAYFGHHRPASTVFGVTELTFPGQVIEISFVIDTKLPA
>NC_016582|19705:83640|28198_29119_-|WP_014172630.1|DBSCAN-SWA
MTTDVTVIGAGLGGRTPARVLHVHGIPATVYEAEASATARTQGGMLDIHEDSGPSALQAAGLTDEFRGLVLEGRQAMRVLDRAGSILLDQADDGTGGSPEVLRGELRQMLLDSLPANTVRWGHKVSGTRAVGEGRHQVTFADGTTATTGLLVGADGAWSRVRPLLSDTTPEYIGMSGVETYLFDADTHHPAGAKAVGGGSLFALAPGKGFLAHREQGGTLHTYVMLARPRDWFADDAAHLSLPNGEGANLAMYDAAELGKALAAHPDDVETALTEYEQAMFPRSAAAATEAPTSTSCSTETTHPTA
>NC_016582|19705:83640|22619_22832_+|WP_148276891.1|DBSCAN-SWA
MTVGHLLQPLALGGARGYRAGGGNGQGRPMWGFALYYAGSDRYEDSRLPTGTPAEALDCACQLHLAAPGI
>NC_016582|19705:83640|32874_33417_-|WP_014172634.1|DBSCAN-SWA
MDDKIWFIGLPYDDDRDASAPADQQCLAEVLEGQGFRTAPADFGPSLEVWLPDPSEFAASVHLGDSWMVQIAVDERRLAEDFDEYRGNTDALAKLIGIVTEYAGTYLGFVTADDDDDLSFMEEDPPVHLGQPLAMVYFGRRYLSGWPDEPQWAADPKARWELPTGVLLVPASSPLEITRA
>NC_016582|19705:83640|55877_57026_-|WP_014172660.1|DBSCAN-SWA
MHVLGRRRRGPLVLTGLAAVLLAASTGLTAAAKPQQADPLQQQVDAIHDTGAVGVLAEVTSPDTRDSARAGTAELGTGRPMPRNGRFRIGSAAKTFTATVVLQLVGEGRMSLEDTVEQWLPGVVRGNDNDGSQITVRQLLQHTSGIRDVLPEIPALNSADGYRAERFRTYTPEELVRLAIQHRPNFPPGDGWSYSNTNYILAAMIIHEVTGRSWAQEVNDRIIRPLGLRDTSMPGAFPSILGPHAHSYAAFGTHTRTDVTVLNSSMAVGSGSIISTTHDLNRFYTALLGGRLLAPAQLDEMTTTKPAPELGVRYGLGLGEIPLSCGGSYFGHPGELLGYRTWGGVTRDGTRTAVVYVTSDGGRNTQQAMSTLVDQELCRTRS
>NC_016582|19705:83640|21534_22590_-|WP_014172625.1|transposase|DBSCAN-SWA
MVLHAARGRSNARIAREAGLHLDTVRCWRGRFAEHGLGGLRDRERSGRPPSFTALQAAQVKALACRLPAETGVSLSRWSCPELAREVVARAIAGSVSASTVRRWLADDALKPWQQRSWIFITDPDFRIKAERVLGLYARTWQGVPLGEDEYVISADEKTSIQARCRCHPTLAPGQARAMRVNHTYGRGGALAYLAAYDVHHAKVFGCTEPKAGIDPFMNLVTQVMSTEPYAGAKRVFWIVDNGSSHRGKKAADRLTSAFPNAVMVHTPVHASWLNQVEIYFSVVQRKVVSSNDFTDLAQVRDRLRTFEDRYNATAQPFQWKFTTSDLDDLLARLDRHTADHHEESSAEPAT
>NC_016582|19705:83640|49868_50036_-|WP_193383687.1|DBSCAN-SWA
MPERSASCEIRQAVAPPPPRTTDATEQQLRDITAAALGEVYCRDNGRRSHGQLAS
>NC_016582|19705:83640|69732_71418_+|WP_014172677.1|DBSCAN-SWA
MRWVRAISSQVEEAAETLGGKAVGLVLLHRLGLPVPAGFVITTQACRAFLRDGRLPDGLDDELATAIADLEVTAGRSFGGPRRPLAVSVRSGAGVSMPGMMSTILNLGLTTEATAGLAVETGDRPFALNSRLRFLSSFASAVTNADAGGVGNASDAGDAGDAGDAGVGHGEDPGRGTKDEETRLADAMKAIEEFVRQRSGQPIPDDATRQLASAVEAVFSSWDTPRARTYRALHDIPHDLGTAVIVQTMVFGNRDDHSGTGVAFSRDPNTGENIPFGEVLFGHQGEDVVSGRSTTRPLRELAEREPAVWAELLDALNRIEGHYRDSCYIEFTFQAGELWVLQVRPGRFVGGAAVRVATELAEERVIGRHEALLRISPRHLRQVRTPRIASSEEADVFARGLGACPGVAVGHVATTADRAVRMAQGGALVVLVRPETSPHDMHGLAAATGIVTARGGPASHAAVVARAMERPAVVGIAGLTVDAGNGTVTAGGRTIGDGTLITIDGTSGEVVLGRPRIVANAADEHLHRLLAWADDTSGDHSRRGESQRLEAAHAALRASGA
>NC_016582|19705:83640|58673_59042_+|WP_014172664.1|DBSCAN-SWA
MNINLSAVIIDAADLEPESAFWHRLLSGSIVKTATHHFLRIDGFPVFVIQLAPGHVPPQWPKGNSQQMHVDLTTDDLAAADRLALEAGARRLHPTDDVDPASQKGGRVYASPAGHPFCLRSG
>NC_016582|19705:83640|61080_61947_-|WP_014172667.1|DBSCAN-SWA
MSSSNAHHSELGAFLKARRTELGPAQVGLPDSAGRRRVKGLRREEVALLASISPDYYTRLEQGRRQASEPVLDALARVLRLDDGERAYMFELSGRDAARPRRRATQKVHPQLQRLLDDLPTTPAVVLGRRTDILAWNPMAAALFTDFARIPEGNRNFVRLVFCEPAIRTLYPDWDWVAQISLAQLRMEAARDPKDPRLAVLVGELSLQDPDFRRWWGAHHVAVQGTGTKTLNHPVVGRLTLDWSFLTCADDPDQQLITLTAEPGTPSHDRLRILASHATQADREGRRS
>NC_016582|19705:83640|49603_49783_-|WP_014172652.1|DBSCAN-SWA
MALRPVQVNIATTSAAHQAELVASLQALGATPAHAGQGQVPWTVLADPEGHEFCLLAPS
>NC_016582|19705:83640|20560_20842_+|WP_014172623.1|transposase|DBSCAN-SWA
MGDTVGRHDLTDEAWAVLEALLPVAGCGCPGRNLRRQVDGIRHRVRAGCPWRDVPERYGPWSSLYRAFRRYQHEGAWNQVTARSSPRCSTRSG
>NC_016582|19705:83640|57337_57916_-|WP_043488426.1|DBSCAN-SWA
MPSSRPLRADARGNREALLAAAREAFLTGETDAHVKEIARRAGVAVGTLYRHFETREALVEEVYRQEVDELCAAPAELLDRHAPDEALRRFLLLLVEHAAVGKGMAVALESIMATDSPIFDDARTQMAQALDQLLKAGAAAGTIRGGVSGHTLLRALGGICGMHATEGWQDEAVRITAILFDGLRFGAQNAG
>NC_016582|19705:83640|19705_20083_+|WP_158502577.1|transposase|DBSCAN-SWA
MDEAVRVADLLFPGVDVEVERLVLTDAEVCVDVRSRAAAAACPECGQKSSRVHCYDEQCLTDRPVAGPRVRIELRAQRLVCENTSCTHRTFTEQIPGPTRRHARRSLPTCSHAGACFGSRGECRF
>NC_016582|19705:83640|67601_68735_-|WP_014172674.1|DBSCAN-SWA
MARLTRAQQQERTRAAVLVAAREEFAEHGYAEAKVDRIAERAELTRGAVYSNFTGKRALYLAVLADAAERARARAEPPMESPDSVGRALGTFARVWLERLPLAGDTPGSGHLQLRSLSGVLDTEPARTALAELVRFEALLLALALESRPAARGRMVRPAQLALTLLHGAAGLAENAPGVGDPFDLARAAEHLADIALNDDAEPPHLPFIPRAQPAEDPWAAPRGLADEITGRAVDLTDDGVVVLLGVSRLSAAEEAVRSARPRDAVTIVVTTSDPAETGRLARLRIADLVACLRRVFAAEELPRPRIVFDDGGTVPAALGRTSVDDLTEIAIRVRDGLIVAHAEGRGAGHAVADSGAPHRGRGTTTPSRRDLRTRPE
>NC_016582|19705:83640|51461_51962_+|WP_014172655.1|DBSCAN-SWA
MPSATRHNRRSDTPPPRTGSSEVEVLRTLLDYLRTSISAKVDGAPEPQVRAAAVPSGTNLLGLLNHLTFVERSMFLGDDVTDWQATFQAAPADSVADIVARYRETVERANDVLDGCTDLGAPVPRPRPGRPAPSVRWALTHMIEETGRHAGQADILRELIDGSTGR
>NC_016582|19705:83640|50098_50704_-|WP_043488421.1|DBSCAN-SWA
MDPKTDDDVLDAVGPRLRALRRDRGITLADLAATTGVSESTLSRLESGQRRPSLELLLPLARIYGVPLDDLVGAPRTGDPRIHLKPIRRYGMTFVPLSRRPGGVHAFKMIIPARPEPLEPTPQTHEGFEWLYVLNGHLRLVIGERDLTLPPGEAAEFDTSLPHWLGSADGGVVELLILFGLQGLRAHVRTDPHRPSQAEPQ
>NC_016582|19705:83640|31590_32175_-|WP_014172633.1|DBSCAN-SWA
MAELIAPTGRLHSSWLTARDEWQPGAHQDGAGLRLVGDDELDSPEGFASWVERLRQQSDRSLPVGEGRVHATHWWIVDGETYLGAIDLRHYLNAFLLEGGGHIGYSVRPSARRRGLASWALGEVLLKAPALGLDRVLLTCDDGNVGSARTIESNGGVLEDVRSTESGVKRRYWITLNDAGHSHSLMAATRTVAS
>NC_016582|19705:83640|63581_63947_+|WP_143675914.1|DBSCAN-SWA
MLGATDRRLKAVVAQVPTISGFEQSRRRVAPDNIAALETALDADERAQLTGEAPRTQALASADPAVAASYRAQDAVGFCLQELPQEHAGTTASPSAPPARHMYEPGVFIDRISHTAAEDRR
>NC_016582|19705:83640|38384_39383_+|WP_014172642.1|DBSCAN-SWA
MTRIAINGFGRIGRNVLRALLERGSDLEIVAVNDLTEPVTLARLLAYDTTAGRLGRPVTADGDALVVDGRRITVLAEREPARLPWGELGVDIVLEATGRFTSAKAARAHLDAGAKKVLVSAPSDGADVTLAYGVNTDAYDPDVHTIVSNASCTTNALAPLAAVLDELADIEHGFMTTVHAYTQEQNLQDGPHRDARRARAAAVNIVPTTTGAAKAIGLVLPNLDGKLSGDSIRVPVPVGSIVELNSTVARDVTRDDVLAAYRAAAQGPLAGVLEYSDDPLVSSDIVGNPASAIFDAALTRVDGRHVKVVAWYDNEWGFSNRVIDTLELLATR
>NC_016582|19705:83640|73187_73970_-|WP_014172680.1|DBSCAN-SWA
MTTTPNEPTTALPGRPPVVDLATWQAARDELLVREKAHTREGDALAAARRRLPMVELDGTVEVVGPDGPVPFLDLFQGRDELVVYKHMWYDGAPHQGQCEGCTTTAWHLKDAAYLNARGVSFAVLTTGRWDEVASYVAFMGYTQPWYSVRGVDVPVGGDMGYLTCFLREGDRVFLTYSTTGRGNERVNGSMGLLDMTPYGRGEAWEDNPQDWPQGGSPCWSWRSDAEGNATWGPTSRPVPQWTRPGATPVETLGRHSHHH
>NC_016582|19705:83640|37317_38274_+|WP_014172641.1|DBSCAN-SWA
MPSSRLRRVAVLVLEGAKPLDVGIPAQVFTTRASMPYEVRVCGAAPGLVTGGDGLAYHVTHGLDALGWADIVFVPGYRFPDRDDPPRAVVDALIAAHDRGARLAAISTGAFALAATGRLDGKRATTHWHYTRALAQKHPLIRVDENVLFVDEGSVLTSAGAASGIDLCLHILRGDLGVAASNHAARRLVAAPYRSGGQAQYVPRSVPEPLGERFAATREWALHRLDEPLSLESLAQHAAVSPRTFSRRFVEDTGYTPMQWVMRARIDLARELLERSKRSVEQIANDVGLGTGANLRMHFQHILGTTPSEYRRTFTRGE
>NC_016582|19705:83640|41585_42068_-|WP_106436498.1|DBSCAN-SWA
MTFDQEWAELVSAAKERQSAGMRLNQALPGPGPGGGANHDLVVHQDDLGAVGHEAYELHDVLRKKADIEGAGMDKSGSGSTLQAARELSAQNMTMGNELSTTVSVWDTQVKTVLQMCAHISNHLDYSKKAHTKDDEYLAASLRHRDGAAVSVSEISQYVK
>NC_016582|19705:83640|80533_81259_+|WP_043485899.1|DBSCAN-SWA
MDRVNDTKTALVTGANKGIGFAIAQGLGAIGFTVAVGARDDARREEAVEHLRAAGVDAFGIALDVTSDDSVAAAAAAIEQTAGRLDVLVNNAGISGRTDGGAQDPTTLDLDVVRTVLDTNVFGAVRVTNAMLPLLRRAKSPRIVNMSSNMGSLTLRTGPIMAAYAPSKSMLNSVTAQYARRLADTNVIVNACCPGYVATDFTGFNAPRTPEQGAAIAIRLATLPDDGPRGGFFDDEGVIPW
>NC_016582|19705:83640|21097_21397_-|WP_014172624.1|DBSCAN-SWA
MADVTSTLPRREGQGEGLLLVVDVVEETALYWDRLGALRGFSSVGRSIGSPVAVGFVRILGPFEAGYEFTAYVLEQALAFLAAEEDVPRLLLPVVVLAP
>NC_016582|19705:83640|75622_76201_+|WP_043488434.1|DBSCAN-SWA
MPKLWNETIEEHRNAVREAILRTTWSLATEQGPMSVTMSQIAEKVGIGRATLYKYFPDVESILSAFHEGHIASHIEQLHQLRESLPDPGERVRAVLERYALISYRRRSQGTEELSALLHRGEAIVQAQRHLSRLFEDVIAQAAAARALRDDIAPRELAAYCLHSLTAAADLPSEAAVHRLVSLTLQGMQTPA
>NC_016582|19705:83640|59463_60261_-|WP_043485893.1|DBSCAN-SWA
MSTDHDQPAHGQVPSAGRPLALITGVGRTVGIGAGIARRLAASGWDIAFTYWAPYDDRMTWGREPGATDEISQALTEHGAATAAIEADLSDPDTPARIFDEAEQRLGHVAALVMCHCESVDSGLLDTSVESFDRHFAVNARATWLLIREFGRRFAAAPGTGRIISLTSDHTVGNLPYGASKGALDRITLAAARELAHLGVTANAINPGPVDTGWMSEEIRERCVRGTPLGRLGTPRDTAHLVDFLCSREGEWINGQLLMSNGGFA
>NC_016582|19705:83640|20838_21036_+|WP_193383686.1|transposase|DBSCAN-SWA
MRRPGGAGRPRRRPDRVRADKGYASAANRRRLRRRGIAATIPDKKDQRANRLARGSKGGRPPKID
>NC_016582|19705:83640|44206_45625_+|WP_014172649.1|DBSCAN-SWA
MGSLGADDPAEVGAYRLLGVLGHGGMGRVYLGRSQGGRLVAVKVVHRHLAADERFRARFASEVAAARLVSGEQNHNRTAPVLTADPEAEVPWVATGYVAGSDLAHMVEEHGPLPERTVRALGIGLAEALGAVHAQGLVHRDVKPSNVLLALDGPHLIDFGIARAAEAATRLTSTGVAVGSPGFMAPEQVTGEAAVGPATDVFSLGTVLAYAASGQQPFPGESAAQLLYRVAHAEPRLDGVAPDAVKELVSACLAKDPAARPTLPEVVRALAGEQDAGASLDSSRWLPTAVADDIGRRAVELLQLESGPADPGLPARPHSPTLVDSAPASGPNAATVTVTAQPKPETTAKPELANKPEPPDAQAKKQGPWLAVGASALLAVLIFGVWNAFQDDDKTAALPNSFVGHWSDSANGYGNQLELNAGRVGEEVGRLTADVDACRRSSRRVWALLPAARMRRPARWSRRRSPFWMPHR
>NC_016582|19705:83640|48013_49318_+|WP_043485891.1|DBSCAN-SWA
MPSSSSAVSDSGQPVPSNLWRDRDFRRLWVGQTASQLGEHACLVVLPLFAVLTLNAGAGQLGALRAVGQAPILLLSLFAGAWVDRWQTRTLMVLTDAGRALALGAAAVAGLLGGLGLPALFVVAFAIGALSVFFDVAYQASSVRLVKRDQLVRANSALEGSRSAAQIGGPALGGALVSVLSAPIAAASSAVFFTLSFLSIRRIGRRESIPKRSERPPRVWRRIHEGLRFVARDTSLRTVCLASAAFQFFFAAVMTVYLLFLPRDLHLSGTAVGLALAATGPGALLGSLLAARLPSRFGYGTVLVSAAALGDGVFLFAPALHGTSVVTVPALLTVNFVFGTFSQLVNVTVMAVRQTVTPDGMQGRAAATINFVGMGLTPLGSLLGGFLAEVWGTRTGLLVTAAGMLLSPALMALSPLARLGRTLPAPPETPVPSA
>NC_016582|19705:83640|81578_81776_+|WP_043488437.1|DBSCAN-SWA
MLVLCSFALVGLTIGLFPTRKLFVMWAHEINRGEQQESYPYPRSHLAFCGVSVIVAVLAAFLLVQ
>NC_016582|19705:83640|78056_79619_+|WP_014172685.1|DBSCAN-SWA
MVPIIIVLIILVVLVFITLIKTIQVIPQASAAIVERFGRYTRTLNAGLNIVVPFIDSIRNRVDLREQVVPFPPQPVTTQDNLVVSTDTVIYYQVTDARAATYEVASYIQAIEQLTVTTLRNIIGGMDLERTLTSREEINAALRGVLDEATGKWGIRVNRAELKAIEPPTSIQGSVERQMRADRDKRAAILQAEGEKQAALLKAETEREVAAILAGGSGATRSTPQSPVRASPVPGHQPLLQDDPRRIGRYHLTARLGQGGMGTVYLGRSPGQRLVAVKAIRPEFAADPTFRERFAREIDAARRVGGFHTAPVVDADSRGDLPWLATEYIPGPSLHDVLRQQGALPTRTLLTLAVGIAEALEGIHACGIIHRDLKPSNIIVSSTGPRVIDFGIARALDSTALTRTNHVVGTQGFLAPEQLTGTSITPAADLYAFGMVLCHAAGATPLTDGESLESALSLLPARFVGIITRCLDHNPNGRPTPTEVLEQLSQNDSPTEDWLPPPVRTMVDLHNAPTAAEPGR
>NC_016582|19705:83640|52325_53927_+|WP_014172656.1|DBSCAN-SWA
MHEDIWGDPTRYRYAAAPRTGLSLPLDDSLERAIQEAAEASGSEDQVEFLMVEGQRLTDLRPLARLRGLRELVVHSPVLKDLGPLALLPTLRRLSVTAPVSDLGPLSALTSLTHLDLEQTMVTDLAPLASLAKLRDLSVTQGPLADLGPLRRLGLMRLYVYRTQVTDLTPLADAPLLWVLGINDCPVTDVSVLTQLPSLTHVLMRRTRVKDLGDLPTRAPHITFEGYDEKSPEPTVTPDTPGDPIDPIDPAELLARYRAAEDKERYRLGLRLLGSRDAVAIEALIRELLSDSDRFTMRGLLLDGGHGSIPFPANPWGIPADADLDAAIGHIWAPLADHLPTFLDILRHETLALGLLTDQDGQPSLAYVFVGWNPLPGRVRLDDLSHWREDEGALRIVHGGAPRTDIDPYLVVPVLGGPVPTPLRELWAVHRFLGDGFQAQYDDRLTTNLGAFCSRNLPGFAERNNGAQPDRFVLFASQDYYNAVLDLDILDQAGNPTITTWIDWEIGARQQFWDWFDAELPDTALLGLRREAR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_158502577.1|19705_20083_+|transposase	transposase family protein	NA	NA	NA	NA
WP_014172622.1|20146_20485_+	hypothetical protein	NA	NA	NA	NA
WP_014172623.1|20560_20842_+|transposase	transposase	A0A0N9SHJ4	Paenibacillus_phage	7.0e-10	35.1
WP_193383686.1|20838_21036_+|transposase	transposase	NA	NA	NA	NA
WP_014172624.1|21097_21397_-	hypothetical protein	NA	NA	NA	NA
WP_014172625.1|21534_22590_-|transposase	IS630 family transposase	NA	NA	NA	NA
WP_148276891.1|22619_22832_+	hypothetical protein	NA	NA	NA	NA
WP_014172627.1|23041_23524_+	nitroreductase family deazaflavin-dependent oxidoreductase	NA	NA	NA	NA
WP_014172628.1|24141_24480_-	hypothetical protein	NA	NA	NA	NA
WP_014172629.1|24978_27909_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_014172630.1|28198_29119_-	FAD-dependent monooxygenase	NA	NA	NA	NA
WP_014172633.1|31590_32175_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014172634.1|32874_33417_-	hypothetical protein	NA	NA	NA	NA
WP_014172635.1|34039_34285_-	hypothetical protein	NA	NA	NA	NA
WP_014172636.1|34487_35120_-	cysteine hydrolase	NA	NA	NA	NA
WP_014172639.1|36190_36592_-	RidA family protein	NA	NA	NA	NA
WP_014172640.1|36695_37079_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014172641.1|37317_38274_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_014172642.1|38384_39383_+	type I glyceraldehyde-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_106436498.1|41585_42068_-	hypothetical protein	NA	NA	NA	NA
WP_014172649.1|44206_45625_+	serine/threonine protein kinase	A0A2R3ZRI5	Marseillevirus	2.5e-15	27.7
WP_014172650.1|45988_47506_+	hypothetical protein	NA	NA	NA	NA
WP_043485891.1|48013_49318_+	MFS transporter	NA	NA	NA	NA
WP_014172652.1|49603_49783_-	hypothetical protein	NA	NA	NA	NA
WP_193383687.1|49868_50036_-	hypothetical protein	NA	NA	NA	NA
WP_043488421.1|50098_50704_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014172654.1|50792_51419_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_014172655.1|51461_51962_+	DinB family protein	NA	NA	NA	NA
WP_014172656.1|52325_53927_+	leucine-rich repeat domain-containing protein	NA	NA	NA	NA
WP_014172657.1|54209_54635_+	hypothetical protein	NA	NA	NA	NA
WP_014172658.1|54631_55003_+	hypothetical protein	NA	NA	NA	NA
WP_106436499.1|55056_55296_+	hypothetical protein	NA	NA	NA	NA
WP_014172660.1|55877_57026_-	serine hydrolase	A0A076YS03	Mycobacterium_phage	6.0e-23	29.0
WP_043488426.1|57337_57916_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_014172664.1|58673_59042_+	VOC family protein	NA	NA	NA	NA
WP_043485893.1|59463_60261_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_014172667.1|61080_61947_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_043488429.1|62170_63088_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_143675914.1|63581_63947_+	hypothetical protein	NA	NA	NA	NA
WP_014172670.1|64295_64931_+	hypothetical protein	NA	NA	NA	NA
WP_014172671.1|65647_66004_+	hypothetical protein	NA	NA	NA	NA
WP_014172674.1|67601_68735_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_014172676.1|69109_69736_+	hypothetical protein	NA	NA	NA	NA
WP_014172677.1|69732_71418_+	pyruvate, phosphate dikinase	H8YJB7	Vibrio_phage	4.5e-51	31.8
WP_043485896.1|71467_72055_+	histidine phosphatase family protein	NA	NA	NA	NA
WP_014172679.1|72155_73145_+	hypothetical protein	NA	NA	NA	NA
WP_014172680.1|73187_73970_-	DUF899 domain-containing protein	NA	NA	NA	NA
WP_078610256.1|74196_75510_-	DUF2218 domain-containing protein	NA	NA	NA	NA
WP_043488434.1|75622_76201_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_043485898.1|76274_77063_-	hypothetical protein	NA	NA	NA	NA
WP_014172684.1|77187_77718_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014172685.1|78056_79619_+	protein kinase	A0A2R3ZRI5	Marseillevirus	5.3e-14	26.2
WP_014172686.1|79550_80450_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_043485899.1|80533_81259_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_043488437.1|81578_81776_+	hypothetical protein	NA	NA	NA	NA
WP_043485901.1|81885_82317_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_014172690.1|82397_83000_-|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	6.9e-39	42.0
WP_014172691.1|83001_83640_-|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	4.8e-38	44.1

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NC_016582|534066:599853|DBSCAN-SWA
GTCACACCAGCCGCGTGTCCTCCTGAAGGCGGGGGAAAAGCGGCTGTGCTGCGGGCAGACGCCCCTCGACCGGTGTCAGCTGTGCGGCGATCCGCGTGGCGGCATCGGGGATGAAGGAACGTAGTTCATCCGCCAGTACGCGGCATGCGGTGACCAGCGTGACGAGAACGGTGTCGAGCCGCTTCGCAGCTTCACCGTCGCCCTGCCGCTCTGCCCGAGCCAGTTCCCATGGCCGAGTGGCATCAATACACCGGTTGGCTTCCTCCACGATGTTCCAGACAGCGCGGATGGCACGCCGGAAGTCGAAGTCGGCCAAGGCGGCGTCGACGAGACCGGGCACCTTCCGGCAGACGTCCACCAGCGCCAACCCACTGGAAGGGGCCGAGACGGGAACGGTTCCGCCGCGAAAGCGGTGAACCATTGTCACGATGCGATGGATGAGGTTGCCCAGTCCCCCGGCGAAATCCGCATCCGCGCGGCCGGTCAGGCGGTCGGGAGTGAAGTCGGCGTCCCCGATCCGGGGCACATCGCGCAGAAGCCACCAGCGCACCGCGTCGGTGCCATGGGCCGCGGCCAGTGCGGCCGGGTCGACGGTGGTTCCGGCGGATTTGCTGATCTTGCGGCCGTCGACGGTGAGGTAGTCGTGGACCAGGATGTCGGTGGGCAGCGGGAGTCCGGCCGACAGCAGCATGGCAGGCCAGTACACGGCGTGGAAGCGCACCACTCCCTTGCCGACCAGGTGGACACGGCGCTCGCTGGTGGCCCACCACTGGTCGTAGGCGGTGTCATCGGTGCCGTAGCCAAGGCTGGTGACGTAGTTGCCAAGGGCGTCCCACCACACATAGACGACCTGGCTCGGGTCTTCGGGCACGGGGATGCCCCAGCCGCGGGCGCGGCTGTGGGAGCGGGAGACGGAGAAGTCGTGCAGACCGCCTTCGACAAGGGCCAGGACCTCGTTGCGGCGGGCGACGGGCTCGATACGCAGGTCGCCGCTGGAGATCAGCTGATGGAGGCGGCCGGCGTAGCGTGACAGCCGGAAGAACCAGTTCTCTTCCGTGACGAGCTGAGGTTCGGTGCCGTGTTCGCCACACCGTCCATCGACCAGTTCGTCAGGGGTGTAGAACTGCTCGCAGCCCACGCAGTACAGGCCCTCGTACTCTCTGCGATAGAGGTCGCCCGACGCGGCGCACCGGCGCCACAGCCGTTCGACCCCGACGCGGTGGCGCGGGTCGCTGCTGGTGCGGATGAAGTCGTCGAACGAGAGCGCCAGTGGACCGCGCAATGCGGCGAACGCGTCGGCGTTGCGGTCGACGAACGACTGCACATCGGTGCCGGCCGCTTCGGCGGCCAGGACGTTCTTCAGAGAGTTGTCGTCGGTTCCGCTGAGCAGCCGGACCTGCTCACCTCGCCTGCGGTGGTGACGGGCCAACGTGTCCGCTTGGACGAGTTCCAGAGCGAAACCCAGGTGCGGGCGCGCGTTGACGTACGGAATGGTCGTGGTGATGTAGCGGCGTGGTGCGGTCATCGGTCCTCCTACCGGGTAGCGAGGCCTGGTCGCACAACAGTCGAGGCCCCGTCCCGGGGCCTCGGATTCGGTACGCGTCCGTGCTCAGCAGCCCCGTCGACGGGGCATCATCCGGTGCTGAGGCGAAAGCGTGATCATGCGCCCGAGAATAGCAACGGAGCGTCGTCGCGGCATGCTGTTTACGCTCCTTGGCGACGCGGTGCTGATCGCCGAGAGGCACGGGACCAGGCTGTCACCGCGGCTGCTGCGGAAGGTGTTGCGCCGCACCCTGGGCAGCGGGGCCGACGGCATCGGCGCCACGGGGCCGCTCTCTGTGAGTTTCTGTGAACTACCGGCTGGCCAACTGCCGCGACCTGCCACATTCCATCGGACTGGACCCCCGGTTCGCATGGCACACCCAGACTCGTGCAGATCCGTCCCAGAACAGCGCATCACTGTGAAGGCTCAGGCGATCTCGACCGCATAAGGGTCCAGAGAGAAGGCAGAGCGCTTCATGCACGACAGCAGCGTGGGCAGCGTCGGCACCAGCACCGGAGTGCCCGGCAGCGAACAACACACGAGTTGGAACAGGCGGCTCGTCGGCCAAGTGGCCATCCTGATTTTGGTGAACGCCATGGTGGACACGGTCGTCACGGCACCGCTCCTCGTCCTTCCCGAGATGCTCGACCACTTCGGCACCGACCAGTCGGCGTGGATCGACGCCAGCTCGCTGCTGGCGGGAGCGATGTGGGCGCCACTGCTCGGAAAGAGCGCCGATATCCACGGCAAGCGCAGAGTACTGGTCATGACGCTGCTCACCGCCTTGGCCGGCGCCCTGGTGTGCCTCGTCGCTCCCAGCCTCTGGGTGTTCATCTTCGGGCGTCTGCTGCAGGGAGCGGCCGTGGGGGCCGTGTTCCTCACGGTCGCCCTCATCCGTGACATGTGCGCACCGGACCTGGCGATGATCGCCACGGGCATCGTGACCTCGGGCTCCGCGCTTCTCAGTATCGGGATGCCCGCTCTCTTCGAGATAACGGCCGCAAAGTTCGGCTGGCGGAGTGTGTTCGTCGCGTCGGCGATATTCGCGGCCACCGCGGCCGTCCTCGTGCGCAGGCTCCTTCCCAAGGACACGCTCAGGACACCGGGCAAGGTCGACATCGCCGGGGCCCTGCTTCTCGGCGGAGGTCTGGCGGCGGTCCTCAGCTATATCAGCCTCGGGTCGGATTTCGGCTGGTTCGCCGTGGGGCCGCTCGCCCTCCTTGTCGCCGGCGCCGCGGCACTTGCCAGGTGGTTCCTGGTGGCGAGCCGGGTTCCCGAGCCCGTGATCGACATCAGAAACCTCGGCAGGCCACTGGAGCTCACGCTCCTCGTGGTCGTCTTCGGAACCGGCGCGTACCAGAGCATGCTCACGCTCTTCGGCCTCATCGCCAAGGTCTCAGCGGATCAGCAGCTCGGGTACGGACTCGCCGCCCCGGGAGCGCTGGGCCTGCTGTACGGGGTACCGGCGATCGGAATCGTGCTCGGCGGCACCCTGGCCGGGGCGCTCGGAACACGCTTCGGGCCGGCCGTGACCCTCGCAGGCGGCGTAGCGCTCGGAACGGTGGGCACCGTCGGGATGTTCCTCGGTGACTCCCGGCTGCCTCTCGCGGTCGTGTGCTCCTTCCTGCTGAGCCTCACCGCAGGAACGCTGGTGACATCCGGCTTCAACATGGCAGCGACGCTCGCGCCCCCGGAACGCCAGGGTGTCGTGTCCAGCATGGTGATGGTCATGGTGGCGACCGGGGCAGTGATCCTGAAGTTCGTGGGTTCAGCCGTGCTCAAGTCCACCAACACGGTCATCGACGGCGAAACGGTGAATTCGGCCGCAGGGGTTCACGACTACATCGCGATGGCGGCCGGCGCGTTCACAGCCGCCGCCGTAGTAGCCGTCATCCTGCTGCGAACCCGCCGCGGCGCAAGATAAGATTCACGCAATTACGGCCATGAACGAGAGATGAACAATGACGTCGATGGATGACATCCTGAGGGAAATCGCCGACCTTCGGGAGGTTATGACGAACCGTTTCCGGCAGGTCGAGGCCCTGACGAATCTCTACGCAATCATTCCCGTCAAACACGCAATGCCCCAACCCACAAAGTGGACGGCCTCACCCGACCTCCTACTATTCCTGATCTCACACATCCAGGAGCGACGTCCGGTTTCCATCCTGGACATAGGAAGCGGCGCCACAACGGTCTGGATGGCAAACGCGCTTCGCCATTTCGAAATCCCCGGGAAGATCATCTCAATCGACCATGACAAAAGCTTCGGTGCCGTGACAGCCGCCACATTGACCCAGCAAGGGCTGGACACATATGCGGACGTGCGTATCGCCCCACTGGTCGAGGTGGACATCAAGGGAGAGCGACGGCACTGGTACGACCCGACGCAGCTCGAGGACGTCGAGAACTGCGATATGGCGGTGATCGACGGGCCTCCAGGATTCACGCATCCACTTTCAAGGTACCCGGCACTCCCCATGCTTGAATCGAAGCTGAGCAGCGATGCGAGGATATTTCTGGACGACGCGAGTCGTCCCGACGAGCGGGAGATAGTCGAGCGCTGGTGCCGCGAGTATCCGGACTGGTCCTCCGATTTCATTGATCACGAAAAGGGGACGGCTGTTCTGGCTCGGCGCACGGTGATTGCCGATGAATACCCGGCGGAGTGAATGGTCTGAGTGAGCCGAGCGAGTGCTGGGGCGGGGTACCGGCCACCGGCACCCCGCCCCAGCCTGATCAGAGGAAGCTGACACCCTGGGCGAGGGCGAGTTCGCTGGAGTAGTTGATGGTGTTGGTGGCCGCGCGCATATAGGCCTTCCAGGCGTCGGAGCCTGACTCCCGGCCGCCGCCGGTGTCCTTTTCGCCGCCGAAGGCGCCGCCGATTTCGGCTCCGGAGGTGCCGATGTTGACGTTGGCGATGCCGCAGTCGGAGCCGGCGGCGGACAGGAAGATCTCGGCTTCCTGCTGGTCGCGGGTGAAGATGCTGGACGACAGCCCCTGCGGGACGTCGTTGTGCAGCGCGATCGCCTCGTCGAGGGTGTCGTAGGTGAGTACGTACAGGATCGGCGCGAAGGTCTCCTCCCGTACCACGTCGGTCTGTTCGTCGACGCGGACGAGGACCGGTTCGGTGTAGGCCGCCGAGGGCGCGGCCTCGGTCAGGCGCCGGTTTCCGCCGGCCAGGATCTTGCCGCCCTGGGCCTGGACGCGGGAGAGGGCGCCCCGCATGGCGTCGAGGGCCGTGGTGGAGATGAGCGGGCCGACGAGCGTGGTGTCGTCGAACGGATTGCCAATGGGGAGCTTGTGGTAGGCGGCGGTCAGCCGCTCGATGAAGGTGCCGGCGATATCGCGGTGGACGATGAGGCGGCGCAGCGTCGTACAGCGCTGGCCGGCGGTGCCGGCCGCGGCGAAGACGATGCCCTGGATGGCGAGGTCCAGGTCGGCGGAGGGGGCGACGATGGCAGCATTGTTGCCGCCGAGTTCCAGCAGGCTGCGACCGAAGCGGGCCGCGACGCGGGGGCCGACCTCACGCCCCATGCGGGTGGAGCCGGTGGCGCTGACGAGCGCGACGCGAGGGTCGTCGACCAGCTTCTCGCCGATGGCGCGGTCGCCGAGCACGAGGCGGTGTACGTCGCGGGGCGCGCCGACCTCCTCGGCGGCCCGGGCGAGCAGGTGGTCGCAGGCCAGGGAGATCAGCGGGGTGAGTTCCGACGGCTTCCAGACCACGGTGTCACCGCAGACGAGGGCGATGGCGGTGTTCCAGGACCAAACGGCGGCGGGGAAGTTGAAGGCGGAGATGACACCGACCACGCCGAGGGGATGCCAGGTCTCGGCCAGCCGGTGGCCAGGGCGTTCGGAGGCGATCGTGCGGCCGTAGAGCTGGCGGGACAGGCCGACGGCGAAGTCGCAGATGTCGATCATTTCCTGGATCTCGCCCAGCGCCTCGGAGCGGATCTTGCCTGCCTCGATGGTGACGAGGTCGGCCAGGTCGCTCTTGTGCTCGCGCAGCAACTCGCCGAGGCGGCGCACAAGTTCACCGCGGCGCGGAGCGGGCGTGGTGCGCCAGGTGAGGAAGGCCGTACGGGCGGCGGCGATGGCTTCTTCGGTGGCGGCGTCGGTGGCGGCCGTCAACCCGAGAAGGCTCTCGCCGGTGATGGGGGTGCGGGCGTGGAAGTCGTTGCCCTCGGCCACGTCGACGCCGATGTTCTGGAGGCCGCCACGGGCGCGGGCGCGCAGCTCGTCCGTGGTGGGCAGTGCGGTGCTGGTCATGGCGGTCCTTGAAGGTGTGAGGGGGCGGGGGTCAGCCGAGGGCGCCGGTGAGGTCGAGCTCGTGGGCGACCTGTGCGAGGGAGCGGTTCTGCTGCTGCTCGTAGAGGGCGAAGGGGTCCAGCACGTCGTGGCCGATGGCGCCGGAGAGCCAGGCGGCGTCGTAGGCGGTGCCTTCGCGCTCGTTGTTGCGGATGCCCTCGCCGCTGAGGTTGGACTGGAAGATGCCGGCGGCGGAGCGGGGCAGAAAGTCCTCGTAGACGACGGGCTCAGCGCTCACCCAGCCCTGCCGCACCAGTTCGCTGACGCTGGTGGGGGGCCGGTTGCCGTCGCGCGGCCGGTCCGGGTCGAGCCGGTAGGTGAAGTAGGCCAGCCCCGCGGCGGCGAGTTCCCGTTCGCTGCCGGGCAGGTGCCGCTCCCACACGGCGCGCGCGATATCGCCCCGGGCGTCAGCAGCGTTCTGGGACACCTGCTCATCGATGTGGCCGAGGAGTTCGTCGTAGAGGGCGCGGCCCTTGCGGGTGAGGGCGATGCCGCGGGCCTCGACCTCGCCGAAGCGGACTCGTAGGGCGCCACTGACGACGCTGCCGTCCGGGGTGCGCATGGCACGGGGTTCGGCCAGCGCCCGGAAGGAGGTCTGCCGCAGCAGGACGTCGGGGCCCTGCCACTTCGGCGGGCCCTGGATGGTGTCGATCATCTCGATGCCGCGCTCGGTCATCCGCCGGTACAGCTCGTCGATGTCCAGGACGCGCGGGGTGAGGTGGTTGATGTGGGTGCTGCGGACGCCGCCGATGTCCGCGGCGACGGCGGAGATCCGCTCCAGAGTCTGGTACCACGCCTGGTCGACGGGCTCGGGCGACAGCTCGAAGGCGTGCACGGCGAGTCGCAGAAAGCGCTCGGCGTCCGCCTCGGGCAGCTCCCGCTCCGCCGTGGCGCGGTCGGCCAGTGCGAGCAGTTCGGCGGGGAAGAGTTCGCGGTCCGCGAGGAAGGCCTCCAGGCGTGAGCGCAGGTCTGCGTCGAAGAAGCGGGGGTCGGCGGGGGTGAGCATGGAGGTGAACACCCGGAAGGGGTTGCGGGCCAGTTCCTCGCCGTCGACCGGCCGGAAGGCGGTGGAGATGACGGGGACGGCGCTGGCGGCGGCCTCCCGCAGATCGTAGAAGCCGACCGGGTGCATGCCCAGGGCCGCGAAGATGCGGGCGACCTGCCGCAGTTCCTTCGGTGTGCCGACGCGGATGGCTCCGTGCCGCTCGGCGGTCACCCGGCTGATGGACCCGAGGCGTTCCGCGTCGGCTCCCTGTGCGCGCAGGACGTCCTCGTTGACCTCGCGCGAAACGTCCACGAGCGTGGTGTAGGCGGGAACCTCCTGCCCGTACATCTCCGACAGCCGCGCCGCGAATGCGGCCCGCAGCTGCCACTGAGTGATCATTGACATGGTTCGGCCTTTCGGTCGGGGGTCACACCACATGGGCTTCGGGGCGGAAATCGGCGCCGTCGCGGAACCGGTCGGCGCTGAGCGGGGAGATGTCGGTGAACGGCTCGCGCTCCAGGTACAGGTCGCGCATGACTTCGCCGATCGCGGGCGCCTGAAGGAAGCCGTGGCCGGAGAACCCGGCGGCGTAGAGGAAGTTGGGCAGCTCCCCGGAGCGGCCGATCAGCGCGTTGTGGTCCGGCGTGTTCTCATACAGGCCGGCCCATCCGCTGACGGTCTCCATATCGGCCAGAGCCGGGGCGCGGTGGCGGGCGACGGTGCGGAACAGCTCCAGCCACTCCGGGGTCCAGGTGGTGTCGAAGCCGTCTTCCTGATCGGGGTCGGCCAGCCCGAACAGCAGCCCGTCGTCGCTGTTGTGGAAGTAGCCGGACGAGGCGAAGTCGATGGTGAACGGGATACGCGGGGCGGGCGGCGCGAGTGGCGCGGTGAACGCCAACTGCCGCCTCACGGGCCGGATCGGGAGGTTGATGCCGGCCATGTCGCCGATCTGCGCCGACCAGGCTCCCGCTGTGCAGATGACGGTGGAGCAGGCGATGCTGCCATGGCCGGTGTGCACCCCGCTGACGCGGTCCCCCGCCGTGTGGATGCCGGAGACGGCGGTGTGGGTGGCGAAGGTGACGCCCGCGCGGGCCGCGGCCCGCACATACCCCTGGACGACCAGTCCGGGGCGGGCGTGCCCGTCGGCCGGGGAGTACGCGGCGGCCATGAGGCCGTCGGTGCTGATGTAGGGACACAGGCGCCGGGCTTCGGAGGGGCTGATCATACGGCTCGGCACGTCGAGGCTGTTCTGGAGCTCGACGCCGGTCTCGAAGTCGCTCACCTGCTGTTCGCTGTCGAGCAGGAAGAGGTAGCCGACGGTGTCGAGCCGGATGTCGGCGCCGGGCCGGTGGGGAAACTCCTGGTAGGCACGGAGGCTGCGGCTGCCCAGCTCGATGTTGAGCGGATCGGAGAACTGGGCGCGTACGCCACCGATCGGCTTGCCCGAGCTGCCGCAGCACAGGTCGCCGCGCTCGACGACGACGATGTTGTGCACCCCGGCCTCGGCGAGGTGAAACGCGGTGCTCGCACCCATGACGCCGCCACCGATGATCACAACATCGGCGGAGGTCGGAACGGTGCGGAAGGCGGAGAAGGACAACGGGCCACTCCCTTCCAGAGGCCACCCCGTCGGACGGAGACGGGTCGTACGAAGACGGGTCCGTTTCTCCGGAACGCTACGGGTCGGGCTGCCTGGTCCGACAGGTGAGGCAGAGGCTCGTTCTAGGATCTTCGGTATGGCGAAGCGCGCGGTACATCGGCGGGCCCGGAAGATCCTGGGCGAGGACCCCGTGGCTCTGGTCTGGTGCGAGATCCACAAGCCCATCCCCACACCGCCCGAAGACGTGCACCGCGCCTCAGGCAAGAAGCGGCTGAAGCCGGGCCGTCACTGGCTGCGGTACATCGGGGCCGTGGTGTTCTTCTTCGTCGTCATCCCGATGATGCTGATCGACGGACTCGACCGGCTGCTCCAGGGGCGGCGGCGCCGTGGACCGCGGGCCGGGGAGCCGCAGACTCCGCCGGAGGACCGCCCCGCTGCCTCCCGCCGCGGCCCTGCCCGCGATCGTCGGCAGGATCCGACCAACGGCATCTTCGACGGCGACTGGAACCTGGCCGCAGGCCAGTTGCTGTTGCGCTGGTACGGGCACTCCCCCAACCCGAAACGCCTGGTCATGCTGGCCCACGATCGCGTCTGCATCGCCACGTCCCCTCGCCGTCGGCTGTCGCCCACCAAGGCCGACGACTTCCGGACCGTCGTGGAGTTTCCCCTCGATCAGGTCCGTGTCGAAGGCGAGGCGGGCCAGCCGCGCGGATTCGCCACTTTCCGGCTCCGCTTCACCGACGGGTCCTGGCTGGAGGTAGGGCGGCTGGGCGAACCTGAGGACGCCGACCATTTCCTCCGCACCATCAGCGGCTGAGCACCAGGAGCGGCCTGGTGGGCGCCACATTGGACACACCGCATGTCTCTGCACCATTATGTGCATATGAACGCACGCATGCATCAATCAGATGCGGAAGGTTCACACCCGCATGGCACGTGCCTTGAACCATCCACCCGAGCCGCCCGGGTCGGCGGATGCCGGTGAATGACGAGCAGGCGACCCCGACCAGGTCGCATACGCATCCCAGCGGCGCGGCGCAGTTCTCCACGGCCGCCCATGTCTTCGCGCTGCTCTCCGACCCGACCCGGCTGCATCTGGTGTGGTCCCTCGCCCGGGGCGAGGCCGATGTCAACACCCTCACCGAGGCCAGCGGGGCGGCCCGCCCCGCGGTGAGCCAGCACCTGGCCAAGCTCCGTCTTGCCGGGCTGGTCCAGGTGCGCAAGGAGGGGCGCCGCTCGGTGTACTCGCTCCACGACGGCCATCTGCGCCGGCTGGTCATCGAGGCCGTCAACCACGCCGATCACATGGTCACTGGGGCCCCGCCGCACGACTGAGACCCGCCCGGGGACGGTGGCGGTGGACGGTCATGCGCCACGGCGTACGGCGACGACCTTGGGCTCGGTCATGGCCTCCACGGCGTACCGCACACCCTCACGGCCGACGCCCGACCGTTTGGGCCCGCCGAAGGGCATGGCGTCGATCCGGAAGTCGCTGCTGTCGTTGATCATCACCGCGCCCACCCGGAGCCGTTCCGCGATGTCCAGGGCGGTGTCCAGCGCGGTGGTGAAGACACCGGCCTGGAGGCCGTAGCGGGTGTCGTTGGCGCGGGCGACGGCCTCGTCCACCGTGTCGATCGGCTCGACCACCAGCACCGGGCCGAAGATCTCCTCGGTCATCACCTTCGCGTCCGCCGGGACGTCCGTGAGTACGGTCGGCCAGTGGAAAGCGCCGTCCCGGCGGCCTCCGGTGTGCACCACGGCGCCGCTCTCGCGCGCCTCCTGTACCCATCCCTCGACGCGCCGCGCCTCGCGTTCGCTGATGAGCGGGCCGATGTCCGTACGGGGATCGGCCTTGCGGCCCACCCGCAACTCCTCGGTGGCCGCGATCACATGCCGGAGGAAGGGGGCGGCGATGCGCGCGGCGACGAAGACCCGCTGCACCGACAGGCAGTTCTGCCCCGCCACGCCGAAGGCGCCCGCCACCACGGCCTGTGCGGCCGCCGGGGTGTCCGCGTCGTCGAGGACGAGGACGGCGTTGTTCCCGCCCAGCTCCATGAGGGTTTTCTTGGCTCCGGCGGCGCTCGCCACCGCGTTTCCGGTCCGGTGGCCGCCGGTGAAGGACACCAGGTCGACCAGTGGGTGGCTGACCAGGGCGTGGCCCGCACCGCTGCCCGTACCGGGGACGACCGCGAGCCGTCCGGCGGGCACCCCGGCGTCCAGCAGGATCTCGGCGAACGCCAGCGCGGTGAGCGGTGTGGCCTCGGCCGGTTTGAGGACGACGCCGTTCCCGCCGGCCAGGGCCGGGCCCACCTTGTGCGCGACCAGGTTGAGCGGGTCGTTGAAGGGGGTGATGGCGGCGACCACCCCGACCGGTTCCCGGGTGTACCAGCCCAGTCGGCCCTCGCCGCGGGAGGTGTCGGAGAACGGCAGGGTCTCACCGGTGAGGCGGTCGGTCTGCCGGGCCGAGAGCCTCAGGGTCTCCGCGGCGCGGGACACCTCGCCGTTCGCCTCCCGTAGTGTTTTGCACCCCTCCCGGGAGATCACTTCGGCCAGCCGCTCCCGGCGGCGCAGGACCAGTGCGGCGGCCTCCTCCAGCGCCTCGCGCCGCTTCCAGGGGGGCCAGCTCTTCCCGGAGGCGCCGGAGGCGACGGCGGTGGCCACGCCGGTGACGGCCTGGTCGACCTCGGTGGGGCTGGTGTCCGTGACGTGGCCGAGGAGGCGGCCGTCTTCCGGATCGTGTACGGGCATGGTGGACGCGCCGTCCACCCATCTCCCGGACCACAGCGCCCCGGCGGGCGGCCGCCAGGTCAGCGGGGTGGCGGGCGCGGTCTCGACTGTCGTCATCGGCTCGCTCTCTTCGGTCGGGTGACGCGTCACGCGCTGGGGTAGTGGCAGGAGACGGAGCGGCCGGTGGGGCCCGTTGTCAGCGTGGGCGCCTGGGTGCCACATCGCTCGGCGGCCCGGGGGCAGCGGGGGTGGAAGCGGCACCCGGCGGGCGGGCTCAGCGGGCTGGGCGGCTCACCGCGCAGGGCGCCGAACTCGCCCTCCCCGTCGGAGTATTCCGGCAGCGAGGCGGTCAGCAGCGCCCGGGTGTAGGGGTGGGCAGGACGTTCGAACAGTTCCTCCCGGGAGGCCACTTCGACGACCTCGCCGAGGTACATGACCGCCACCCGGTCGCAGATGTGCCGTACGACGCGCAGATCGTGGGAGATCATCAGCAGGGTCAGATCCAGTTCGTCCTTCAGCTCGACAAGGAGGTTGAGGATCTGGGCGCGGACCGAGGCGTCGAGCGCGGAGGTCGGCTCGTCACAGATCAGCAGGCGCGGGCGGAGCAGCAGGGCGCGAGCCACCACGAGCCGCTGGAGCTGGCCGCCGGAGCATTCGCCGGGGCGCCGGCCGAGGAACGAGGCGTCGAGCCCCACCTGGTCGAGGACCTGGAGAATGCGCTGATGGCGCTCTTCCCGAGGGCCCAGGCCGTGCTGGGCGAGCGGTGCGTCGAGGCTGGTGCCCAGCCGCATCCGCGGGTCCAGTGCGGCGAACGGGTCCTGGAAGACCAGTTGCATCGAGCGGCGCAGCACCTTGCGGTCGCGCCCCCTGGTCCGGGCGACATGGACGCCGTCGAAGAGGACGCGCCCGGAGTCGACCGGGGTCAGCCCGAGCATGGCCCTGGCCAGCGTGCTCTTGCCACAGCCCGACTCACCCACAAGACCCAGGACCTCTCCGGGGGCGATGGTGAAAGACACATGGTCGACCGAGCGGACGTAAGCCTTGCCGCTGAACACCCCGCCCCTCACCGGGAAGTGTTTGACCACGTCCTCCACGGTGACGAGCGGCTGTCGCGCCGTGAGGTCGGGGGCGCGGTCCGCTTTCGCGAGCGCCCTCATACGCCCACCGCCTCGCCACGGAGTTCGGTGCCGTGCTCGGACGCCCAGCAGCGGCAGCGGTGTTCACCACCGCAGGTGTGCAGTGGCGGCTCGGCGCCCGAGCACCGGCCGGCGATCCCCAGGTCCTGGGAGAGCGGACATCGGGGCTGGAACCGGCATCCGTGGTCCAGAGCGCGGGACTGTGTCGCGCTGCCCGGGATGGCGAAGAGCTTGCCCTCCTCGGACTGGAGCAGCGATGCCTTCAACAGGGCGCGGGTGTACGGGTGTTCGGGGGCGTCGAAGACTTCCCGTACCGATCCCTCCTCCACCACACGCCCCGCGTACATCACGGCCACCCGGTCGGCGATCGAGGTGACGATGGTGAGGTCGTGCGTGATGAGCAGCACGGCCATACCGGACTCGCGCTGCTTGTGGCGGAGCAGCCGCAGGATCTGGGCCTGGACGGTGGCGTCGAGAGCGGTGGTCGGCTCGTCGGCGATCATCATGGCGGGGTCGGCGGCGAGGGCTGCCGCGATCATCACACGCTGGGCCATTCCGCCGGAGAGCTGGTGTGCGTACGCCGAGGCTCTGCGCTCGGGTTCGGGGATGCCGACGTCGCGCAGGAGTTCCACGACCCGTGCCCTTGCCTGGCGGCGGCTGAGCCCTCGGTGCAGCCGGAGCGGTTCGGCGACCTGGCTCCCCACCGTGCAGGTGGGGTCGAGCATGGCCTTGGGCTGCTGGAAGAGCATGGCGAGCCGGTGGCCGCGAACGCGGTTCATCCGCTTCGGCGGCAGGGTGGCCAGGTCCTCCTCGCCGAGGGTGATCCGGCCGCCGGTGACCCGGGCGCCGGGCGGCAGCAGCCCGATGGCGCTCAGCGCCGTCATGGTCTTGCCGGAGCCCGACTCGCCGACCAGCGCGACGATCTCGCCGCGCCGGACGGTCAGGTCGAGGCCGTCGACCGCGGGGGTGGCGGAAGCGTGACCGGGCTCTGAGAACTCCACCCGCAGGCCCCGGATCTCCAGCGCGGTGTCGCCGGTGGTCTCGGGGGTCGGCGGGGGGCGGTATGGCAGGCGCATGTCCGGGGTCCTTTCAGCGTCGGACCGCGCGAAGGCGGTTGCGCACGGTCACGGTGGCTTCTTCGAAGTGCTGGGCGAGGGTGGCCAGCGCGGCGGCGACGTCATCGCCCGCGATCAGCCGCGCCAGCTCCCGGTGTTCGTCGACGAGGTCGAGCCGCGCGGGGTCGGCATCGGCTTGGAGGTTGAGACACAGCCGGGTCTCGGCGATCACGGTGTCGAACATGCGGCGCAGGCGGGGGCTGCCGGCCGCCTCGATCACCAGGGAGTGGAACCGCACATCGAGGTCGGCCACCTTCGACCAGTCACCCGTGCGCGTGGCACGGGCGAGCTCGTCCACCGTCTCGTCGAGGGCCGACAGCAGGCCGGGCGGTCTGGGCGCGGTGATGACCCGGCGGAAGGCCGCGGCCTCGAGCGCCTCCCTGGCGTAGTAGATGTCGAGGACGTCGGCCTCGCCGAGCAGCGGCACGAACACCCCGCGATGGGGCTCGCTCAGCAGCAGTCCCTCATGGACGAGGCGGGCGAGGGCCTCGCGCACCGGGCCGCGGCTGACCCCAAGGGATTCGGCGAGTTCGGCCTCGCCCAGCTGGGAGCCGGGCGGGAAGGTGCCGGTGAGCAGCCGGGACCGGATCTGCTCCACGACCTGTGCGGCGAGCGTGGTGCGGCGGACCGGGGTAGCCGACGGTGCCGCCGGCGTGGAGTCATGAGGCATCCGTCCTCCTCTTGCGCTTCAGTTCCATGCCGTGGCCGATCAGGGTGACGCTCAGCGCCGTCACGAAGATCGCGGCGCCGGGGGCGATCACCAGCAGCGGGAGGCGTTGCATATAGGGCTGGGCGTCCAGCAGCATGGCGCCCCAGTCGGAGTCGGGCGGCTGCACGCCCAGCCCCACGTACGACAGTCCGCCGACGGTGATGAGCTTGTGGCCGAACCGCAGAAAACCCAGGGAGAGCACGGGCCGCAGTGCATTGGGGATGACATGGCGGAAGACGATGAACACCTTGGAGCAGCCCAGCGCCTCGGCGGCCTCGATGTACTCCCGGCTGTTGATCTCCAGGGCCAGGCCGCGCATCAGCCGGGCGAAGGGGGTCCACCCGACGATGGTCAGGGCCGCGATGAGCATGCCGTAGCCCGTGCCGAAGGCCGCGATCAGGAACAGGGCGACGATCACATCGGGGATGGAGATCAGCAGATCGGTGGTGCGCATGACCACCTCGTCCACGATCCCGCCGCGCCGCGCGCTGAAGGCTCCGATCACCGTGCCGATCACGGCGGAGAGCAGCAGGGTGACCGCCGCGATGGACACCGAGAAGCGCCCGCCGTACATCAGCCTGCTGAGAATGTCCCGGCCCAACTGGTCCGTGCCGAGCAGATGGTGGGCACCGGGCCCGGACAGCCGCTGTCCGAGGTCCTGGTGGGCCGGGTCGTACGGTGCGATCCACGGGGTGAGCAGCAGGACGGTCAGCACCAGGGCCAGGACGACGGCGCCGATGCGCAGCGTCCAGTGCCGGCCGGTGACCGCGCGCAGACCGGTGGCGGTCAGGTGCGCGAGGCGCCGGGGTGCGGTGGAGGGTACGGGATCACGGGAAAGAGAGCTAGACAGCGCCATCGCGTACCCTCACGGCCGGGTTGATCAGTGCGTACAGAAGGTCGGTCACGGTGGTGATCAGGACCGCCAGCGCCACGGTGCACAGGATTCCGCCCTGGATCAGCGGGACATCGTGGTTGACCACGGCGCTGTAGACGAGCCGGCCCATTCCGGGGATGGCGAAGATGACCTCCACGACCACCGATCCGCCGAGCAGCCCCGCGAACCACAGGGAGAACAGCGTCATCACCGGCAGCAGTGCGTTGCGCAGCCCGTGCCGCAGCAGGGCCTGGCCTCCGCTCAGTCCCCGGCTGCGGGCGGCGGTCATGTACGGCGATGCCAGGACATCGCTCATCGCCGCTCTGGTGACCTGGGTGAAGTAGGCCATGGGCCGCAGGGCGAGGGTGAGGGCGGGCAGGATGATGGAGGTCGGGTCGCGCCATCCGGCCGAGGGCAGCCAGCCGAGGTAGCGGGAGAAGACCAGCACCAGGATGGGGGCCAGCCAGTATTCGGGGACGGCGACGAAGCTCTGCGTCAGCAGGGTCACTCCGTTGTCGACCCGTTTCCCCGGCCGCATCGCGGCGAGCGTGCCCAGGGGCAGGGCCGCGAGGAAGGCCAGCCCGATGGCGATGACGGCCAGGGTGCCGGACACGCCGATGGCGGTGCCCAGCAGTTGGTCGACCGGGGTGCGGCTGGTGAAGGACATCCCGAAGTCCCCACGCACCGCCCGGCCGAGCCAGCTCAGATACTGCACGAGGATCGGCCGGTCGAGCCCGAGCTCGGAGCGCAGGGCCGCGATCGCCGAGGGGTCGAGGGCCTGGTCGGAGACTCTGGACCGCAGGATCGTCCGGACGGGGTCGCCGCCCGAGGCGTACGGGATGGCGAAGGTGGCGGCTGATACGGCGAGCAGGGTGATCAGCAGCACCAGAAGCCGCCGCACGATGAATCTGACCATCGTTCACTCCTCCTTTCCGGGCTCTTCCGGCAGGTGGGCGGTGGGCTACTTGATGATGTCGAGGGCCCGGTAGTAGGCCCCGGCGAACGGCAGGAACCAGGGCGGCCCGAAGTGTCCGGGAACACGTGGGAACTTCATGCCGCGCCAGATGTTCGCCTCGGGTCGGCCGTCCATGACATCGGCCATCTGCCGGCCCATGTGGGTGGCCATCTGGACCCCGTGGCCCGAGTAGCCGACGGAGTAGAACAGACCGTCCCGCTCGCCGGAGTGCACCATCTGGTCGAGGCTGATGTCGACGAGACCGCCCCACAGATAGTCGATGCGCACGCCGTCGAGCTGCGGGAACACCGAGAGCATCCCCTTGCGCAGAATCTGTCCGCTCTTCCGGTCGGACTGGGGATTGGACATGGCGAACCGCGCCCGGCCGCCGAACAGCAGCCGGTTGTCGGGGGTGATGCGGAAGTAGTACAGGATGTTCTTGGAGTCGGAGGCCATCCGGCGGGTGGGCATGAGCTCGTCGACCACCTCCTGCCGAAGCGGTTCGGTGACGATGATGAAACTGCCGACGGGGATGATCCGGTTGCGCAGCCAGCGGAACGGGGACCCGGTGTAGCCGCTCGTGGCGACCAGCACCTGATCGGCGCGGAGGGTGCCGACCGGGGTGGTCAGATCGTGCGCCGTACCGCTGACCCGGCGGGCCCTGGTGACCGGGGCCTTCTCGAGGATCCGCACCCCCTGAGCGGCGGCGGCCTCGGCCAGACCGCGGACGAACTTGCCCACGTGCAACCCGGCGCCCTGAGGGTCCGCCATCGCGCCGTGGTAGTGGTCGGATCCGACCTCGGACCTGATGTCCTTCTTGGGGATCAGCTGCGTGGGGTAGCCGATCAGGTCGGCGAGTGCTTCATGGGTGCGGGCCAGCCGCTCGTAGTGCGCGGGCTTGGCGGCCAGGTTGAGCTTTCCGGTGCGGGAGAAGTCGCAGTCGATCTCCTCCTCCACCACCAGCTTCTCGACGGTGTCGATGGCCTCGTTGTAGGCCAGGTACGCCGCCTTGGCGGTCGGGATGCCATAGCGCTGCACGGCGGTGAGGAAGCCGATGGCCAGCCCCGTGGTGCACATGCCACCGTTGCGCCCCGACGCTCCCCAGCCCACGCTCTCCTGCTCCAGTACGGTGACCTGGGCGCCCTTACGGGCCAGGTGCAGCGCGGCGGACAGTCCGGTCAGCCCGGCCCCCACGATCGCCACATCGGTGCGGCCACCGACCTCCGCCGCGCTGCGGTCGGGGCCGGGCGGGGCCGTGTCCAGCCAGTACGGAACGGTTTTCACCGTGCTCACAGCCCGAGCAGCGCGGGCAGTTCGGACAGGGCCGAGACCTCGTGGTAGCCGTAGTACGGCACGCTGGGCTCATAACCCCGGTTGACGTAGACCTTGTTGGGGATCCGCAGATCGTGGGCCGGGATGAGGTCGTAGCGCAGGCTCGAGGACACATGCAGGATCTCACCGGGGTCGCAGCCCAACTCCTCCAGCATGTACTCGAACGCCTGGAAGCGCGGCTTGTACGCGCGGGCCTGCTCGGCCGTGTACACGGCGTGGAACGGGGCGCCCAGCTTCTCGACGTTGCCGCCGATCTGGTCGTTCGCGGCGTTGGAGAGGATGACCAGCGGATAGCTGTCGGCGAGGGTGCGCAGCGCGTCCGGCACATCGGGGTGCGGACCCCAGGTGGGCACGGCGGCGACGATGGCCGCGCCGTCCGTGTCGCGGTACTCGATGTCCCACAGGTCGCAGGCCCGCTTCAGGGCGTGCCTGATGACGTCGGGGTAGAGCTGGTAGGCGCCCAGCACCTCGTCGATCCGGTACGCCTCGAAGTCGTCGAGGAAGTCCTCCATCCGGTCGGCCGCGACGCGATCGGCGAACAGCTCACGGGTGAGGGCGGACATCCCGAAGGCGGTGAGGGTGCCGTAGCAGTCGAAGGTGATGTACTTGGGCCGGAAGTCGATCACAGCGTGCTCCTTTGGGTGGTGCGGCGTCACTTCGTGCCGAGTTACTTCGTGCCGAGGGAGAGGTTCGCGGTGAGGGTGTAGTACGGGTGGACGGCGAAGCCCTTGAGGCCGGAGGCGACGGCGACGGACTCGGTCTCGTGGACGAGGAAGACATCCACGGCGCGGGACTGGAGCTCCGCCGCGACCTTGGCGTAGTCGGCGTAGCGCGTGTCGGGGTCCTTCGCGGACGCTGCCTTCTTGATGAGGCCGTCGGTCTTCGGATCGCAGTAGTGCGAGAGGTTGTAGCTGCCCTTGCAGGTGTAGTCCGCGGTCAGATAGCCCAGCGGGTCGGGCATGTCGCCGAGGTGGTTGCGGGAGAGCAGGGCGGCATCGAAGTCGCCGGAGAGCAGGTCGGGTTCCACCGAGGCGTAGTCGGCGGTGCGGATGCTCGCCTTCACGCCGATGGCCTTGAGTTCCTGCTGGATGATGGCGGCGAGATCGGAGAAGCCCGATCCCTCGTTGTAGGCGATCAGGGACACTTTGATCGACTCGGGCTTCACCCCGGCCTCGGAGAGCAGGGCCTTGGCCTTGGCCGGGTCGGCCTTCACCGGGGCGGCCCCGTCGGGTGTCCAGGGTTCTCCGGGGCCGAACGGGCCGACGGCCTGCTGCCCCGCTCCCTGGTAGACGGCGTTGGTGATCGCCTTGGTGTCGATCGCCGCCTGGAACGCCTGCCGCACCTTCTCATTGTCGAAGGGGGCTTTTTTGTTGTTGAGGACGAGTTCCGTGGTTCGGGGAAGTTGTTCGGTCAGCACCTCGACGGAGGAGTTGCCCTTGAGGTCCTGGACGCTCGGGACGGGGAGCTTTCTGGATATCTGGGCTTCCCCGGTCTGTATCTGGGTGGCCCGTTTGGCGCCGTCCGCGATGAACCGTACCTCGGCGGAGGCCAGCTTCACCGGGCCGTTCCAGTACTTCGGGTTGCGCTTGAGCTGGATTGCCTGTTGGGGGATTTCCTTGGTGATACGGAACGGACCGGTACACGTTCCTTCGGGGTTGGTCGACGATCCGGTGTATGCCTTCGGGGCAAGGATTCCGGTGTTGGGGGCGGCGAGCCGGTAGGGCAGCAGGGCGTCGGGGGCGGGGGTGGTGATCCGCACGGTCGAGCCGTCCACCGCTGTGACTGCGGCGATCGTCTCGGGCGAGAAGCCGGGGGCCGGAGTCTTCGCGGCGAGCGCGTGTTTCAGGGCCCCGGCCACCGCTTTCGCGTCGAGCGGGGTGCCGTCCTGGAATGTCACTCCCGGGCGGAGGGTGAAGTCCCAGGTCGTCGGGCGGGTCTGTTTCCAGGAGGCGGCGAGCATCGGTTTGATCCCGCCACCCGTCTGGTACTTCACCAGGGTCTCCAGGCAGCCCGCCTTGCTGAGGACGAAGGAGTCGTCGGTCTCCAGGGCCCAGTTGGCGGCCGGCGCGAACGGTTCGTCGACCACGATGGACCGAGCGCCTGTTGCGCCGCCGCCGCTGGAGGTCTGGCCGCCCATTCCGCAGGACGTGAGCGTCAGGGTCGTTGCTATCAGTACTAGGGCCAAGCGCGGTTTGTTCATGGGTCTCACTGATCCGATTGGGGTTACTGAGACTTCCCAGCCGTTCGGGGAGTCGGCGCGGCCGAGGATGGCCGGAATCGGGGAGGTGGCGCTTGGTTGACGAAGGTAAGCGGCGATGATGGCGCTGTCGATAGGTTGTCGATGATATTTTGTAAACAACCCATTGCCGTCATGTCACCTGCTCGCCGAAGCCGGAATGTGCGGGCGGCAGCCGATTTCCCGGAAAAGGGCATGCCGAATAGATCCAGGACCCTGACGCCAATTGGTCTGGACGAATGCCTGATATGGCGGCCCCGGCCGTGTCAGCCGGGGCCTGATGTCATGTCATGTGGTGGGCGAGCGCCAGATGAGGGTCGTCCGCGTCCGGCCCGAGAGCCGGGTCGGTGTGCACCAGGGCGGCGGTCAGCCGGGGCACCGCGTGAATCAGCGCATGCTCGACGTCGACCGCCACGGCATGCGACTCCCGTACGCTCAGCCCTCCGTCCACCTCGACCGTGGCCTCGGCGCGCAGCTTGTGCCCGATCCAGCGCATCCTCAGCTCACTCACGTCGCGCACCCCGGGAACCTCGCGCACCGCGGCCTCGCCCTTGTCGACGAGGGTGGGGTCGACGGAGTCCATCAGGCGGCGGAAGACCTCGCGTGTCGCGTCCTTGAGGACGAGCAGGATCGCAGCCGTGATGAGCAGGCCGACAATCGGGTCGGCGAGCTGCCAGCCGAGCGCGGCGCCGCCGGCGCCCAGCAGCACGGCGAGAGAGGTGAAGCCGTCGGTGCGGGCATGCAGTCCGTCGGCGACCAGGGCCGCCGAGCCGATCTTCCGCCCGACCCGGATCCGGTAGCGGGCCACCCATTCATTGCCGATGAAGCCGACGACCGCCGCGATCGAGACGATGCCCAGATGGGAGATGTCGCGCGGATTCATCAGCCGGTCGATGGCCTCATAGGCGGCCAGTGCCGCCGAGGCGGCGATGGTCAGGACGATGACGATTCCGGCCAGATCCTCGGCCCGCCCGTAGCCATAGGTGAACGTACGGTTCGCCACACGCCGCCCGAGGACGAAGGCCACGCCGAGCGGAAGTGCGGTCATCGCGTCGGCGAAGTTGTGGATGGTGTCGCCCAGCAGCGCCACCGAACCGGAGATGAGGACGACCACGGTCTGGAACACCGCGGTGGCGCCCAGGATCGCCAGGGACAGCCAGAGGGCGCGCATACCCTCGGCGGACGACTCCATCGCGGAGTCGACCTTGTCCGCCGCCTCGTGCGAGTGCGGCTTCACCATGTGGGTGACCTGGTGCTTCCAGCGGGACCAGCGGCCCTCGCCGTGGCTGTGGCTGTGGCTGTGGTCGTGATCGTGGCTGCGTCCGTGGTCGTGGTCGTGGTCGTGGTCGTGCCCATGGTCATGAGCTGATGCATGGCCCTTGGGGTGGGCATGTGCTGGAGACGGGGGATGGGGGTGTTCGTGGGCCTTCATGCGTGGCTCACCTCTCAGGAATGTCGCCGCGGGAGAGTGATGTCAGGGCGCCCTCCTTCTATTATGTGCATACGCGTGCACCAATGCACTTGTGGGATCACACAATGATTTCGTGACTACCCAACCGGGAGTTCCCAGCTCCGGCAGAAGTGGGGTTGGCTCATCGGCTGCTCGCGGTCGCGGCGATGGCGGGCAGGATCGCGAGGGCGAGGACGCCACCCGTGAGCGCGAGGATGGGGTAGCTGGCGGTGGCGACGACGATGCCGGAGGACAAGCCGCCGGTGGCGCCCGCGATGGCGATGGAGACGTCGACCGTTCCCTGGGTCTTGGCGCGGGTGGCGAGTGGCACGGTGTCGGTGATGATCGCCGTGCCGGAGACGAGGCCGAAGTTCCAGCCGAGGCCGAGCAGGGCCAGGGCGAGCGCGAGGAGGGCGACGGAGTCGCCGGGGGCGGTGGCGGCGAGGATGCCGGCGGCCAGGAGGGTGAGGCCGGACGCGGCGGCGATCTTCGGCGGGCCGTAGCGGTCGACGAGCCGGCCTGTGATCGGTGAGGGCAGGTACATGGCGCCGATGTGGATGGCGATGACGAGGCCTGAGGCGGCGGTGCCATGGCCGTGGTCGTGCATATGGACCGGGGTCATCGTCATGATCGCGACCATGACGAGCTGGGTGAGGATCATGACGAGCGCGCCGAGGACCACGCCTCCGCGGCGTTCGTGTGCGGCGTCGGTGGCTGGGGACGTATCGGTGGCGGAGTTGCTGGACTGTTCGGCGGCGGCGAGGGTGCGGGCCGTGAGCAGCGGGTCGGGTCGCAGCCAGATGGCGAGGACGAGCGCGGCCAGGGCGTAGGCGGCACCGCCCAGCATGAAGGGGCCGGCCAGGTGGGGGATGCCGAGGGTTTCCGCGAGGTCGCCGGTGGGTGCGGCGAGGTTCGGGCCGGCGACGCCGCCGAGGGTGGTGGCGACCAGGACGGTGGACACGGCGCGGGCGCGGTGGTTCGGCTGGGCAAGGTCGGCTCCGGCGTAGCGGGCCTGGAGGTTGGTGGCGGTACCGGCTCCATAGACGAACAGGGCGATGAACAACAGGACGGAGGTGTCCAGAACGGCGGCGGTGATGACTCCGGCGCTGCCGATGGCTCCGGTGAGATAGCCGGTGGCCAGGCCGGGGCGGCGTCCGCGGGCTTGGGAGATGCGACCGACGGCGACGGCGGCGAGTGCGGACCCGGCGGTGAACAGGCCGCTGGGCAGCCCGGCGAGGCTGCTGGTGCCGAGCATGTCCTGGGCCAGCAGCGCGCCGACGGTGACACCGGCGGCGAGTCCGGCCCCGCTGAGGATCTGGGAGGCGACCAGGACGCGCAGGATGCGGCGCTGTGCCTGGGCGGTGTGGGTGGTCTCGGGGGTGTCGGGGGTGTCGGATATCGGGCCCGTGGTGTCGGCGTCTGGTGCGGGTCTGGTCATGTCTCTTCCGGTGGCGGTGGGTGGGGCGGTGGCGTCTCGGAGCGGCGACCTGTGCCCGGGGCTCGGCCAGCGCCTGCCGGGCTCGGCGCCGTAGGGGTGGTTGCTGGAGGGGTTGCCGAAGAGGTCCGTCAGGTGCGGCACCAACACCTCGACCACGCGAGGGTCGGCGGGGGTGGTGGCGTTGCAGTCCAGGTAGACCGGTCCGCCGGCCGGCCCCGGAGGTAGGGGCGGGGGCCGCCGTTCATGCCAAGCCCCCGGAGTCGACGGGCAGTTCGGCAAGCCGCCACTCCAGCATGCCGTCATTGAGGCGGACGGCCCGCCGCCCGAGGTCGGTCAGCAGCCGTACGGCGTCGTAGGCGAGCACGCAGTACTCGCCCCGGCAGTAGACGACGATCTCCGTCTCCTCGGGCAACTCGCCGATCCGGCGAACCAGTTCGTCGATCGGGATGGACACCGCGCCCGGGATGTGCCCGGCCCGGTACTCCTCCGCCGGCCGTACGTCCAGCACCACCACGTCCCCGGCCGCCACGCGGGCGCGCAGTTCCTCGTGGCCGACCTCCACCGCGCCGTCCTCACCGAGATAGGCGTCCCGGGCCGCGGGTACGGCGGCCTGGTGGGCCTCGGCGACCTTGCGCAGCAGCGCGAACAGCTGGGCCACGTCGTCGCCGGCGAGCCGGTAGTGGATGCGTACGCCCTCGCGGCGGGTGGCGACGAACCCGGCTTGCTTGAGGGTCTGCAGATGCGCTGAGGCCGTGGTCAGGTTCAGCCCCGCCGCCTTGGCCAGGGCATCGACCGTGCGCTCGCCCTGGGCGAGCAGATCGAGCAGTTCCAAGCGCTTTCCGCTGGCCAGCGCCTTGCCGCTGGCTGCGAAGGCGTCGTACAGCTGCGCCTTCGCACTGGCCGTGGTGCTTCCCGCCATGGGCTTCCTCCATAAATCCATGGAATATCGTAGAAGATGGCGGGAGTGGTGACCACCCGCCTGTGGAGGACGAGCACGCGATGGTGCGCTGCGACATCGCGTGCCGCAACGCCGTCTACGCCGTCACCTCTGAAGTTCGCGCTCGCGCAGGGCAAAGGGTTCGACGGTTTTCAGCCGCGCCAGCGGGAGGACAGGATCGCGCTGTCGAACTGATCGGTGCCCCAGCGCTCCGTGAAGTAGGTGTGCAGCCGGGCGGAGGAGACCCGGGAGACGGGATAGCCGAGCCGGCTCAGCTCGCGGTTGAGCCGCAGGGCCCGGACCACGATCCGCTGGGCGCACACCCAGGCCGGGGTCGCGCGCAGCAGTTCCAGCATCAGGTCGTCGGGCGGTACGCCGGGGGCCCAGCAGAAGCCGCGGACCAGGGCCGCCGCAGACTCGGGCGTCGCCCGCAGGCCGACCGGGCTCGACCAACACCGGCTCGGTGCCGGTGAGGGTGGTGACGCCCGCCGCGACGGTACGCGACTCCTCGGCGAGATCGTGGCCCGTCTCCCGAGGCCGGAGGGGCACGGTCCGCAACGACGGTGCCAACCGAGGGGCGCCCTTCGCCGGGTCCGCCTGGAGAGCGTAGAGCCGGTCGCTGAGATCGTCCCTGGAACCGCTGATCACGGTGAGCCGTCCCTGAGCGGCCTCGGTGAGCGCGCGGGCTAGCGCCACCTCGGGCGCGCCGTGGCAGCCGGATCCGGGCACGACGACCGGCAGATCGGGCGACCAGACGCTCACGTGGTAGCACGGAACGCCGGTGCCGCCCTCGCCGGGCGGCCAGGTCGCGTCGAACGCGGTGACGGAGACACCCGCTGCGCCGAAGCGGTCGAGCAGTTCCGCGCAGTCGGGGTCGTCCACGGAGGGCAGGTCGAGACGGGGGCGTTCGGCCCTGGGCAGTGTGGTCAGCCGCGCCACGGCGTCCCGTTCGATCACCTCGTACAGCGCGTGAAGGGCCGCCTCCGCCGTTGAATTCCCGCTGGCCAGGCCGTTGGTGGAAGTTGCGAAGGGGTGGTGGGTCCACTCCCGGCGCACCCGGCCGTCGAGACCCGCCAGGCCGACCGAAACCGATTCGAAGGTTGACCGTGGTTTGCCTCACCCGGTCACGAAGGTTGTCACGCTTCGCGCGGGAAGCTGGCCCGTGAAGGAGCCGTTCGACACGCTCATCGCGCCCAGAGACGCGAGGTTTCTGCTCGCGTCCGTCAACCAGGACGACACACTGGACGAGGTGTTGTTCACCAGGGTGAACGGCTGGCTCACCGACGAGGTCCCCTTGTTGATGGCGATGATGACCACTTTGGAGTCACCACCCTTGTACGCCAAGACGTAGAGGTTCGACTGGGGATTCGAGGTCGCGTCGATCCGCACATATCCCGGGCGGACGAATTTCGAGAAGTGCGCCATGGTGGCGCCGCGCTTGCTGATTCGCCCGTCTTCCCTCATGGGGCCGTAGCTACGCCTGATGTACCACCACACATACGCCTGGAACTCGGCGTCCACCAGGGCATGGTGGATATGTTCCGCCACGTCGAGCGCTTGGGGCCAGAGGTCCGCCGAATCGCTGCTGTTGGGATAGTAGACCTCGGTCATCCAGAGTTCTTTGCCCCTGCCCTTTTCCTTGAAGAGGGGGTAGGGGAAATTCTGGTACGGCGTGCCGTAGAGATGAGCCCCGAGAATATCCAGGTTGGCGAGCGCTGTCGGGTCGTTGAGAATCGGATCCGAGAAGCTCTTCACATACTGGAAGGACTCCGGCGCGATCACCTTGATCTCGATCGAGCCGGCGTTCTCGCGCAGGAAACGGATCATCTCGGTCGGAGTCCACCACGTCCAGTCATGCGCGTAATCGGGCTCGTTCTGCACCGAGATGGCGTACAGGCTCACGCCGTTGTCCTTCATAAACCTGCAGAAGTCGTTCAGGTGCTGCGCATAAGCGCCGTACATGTCGTACCGGAGCCGCTTTGCGTTGGACTGATCGCCGTGGACGAAGGTCTCGACCATCTGAGCGGGGGGATTCCACGGCGACGCGATGACGGCCGCCCCGTACTCGATCGCACGCTTCGCCGTCGCCACCTCGCGGCTCCAGTCCGCTCGGTTCTCGTGAACGGGGATTCTCAGCACGGAAAACCCAAGCTGCCCCTCGCCGTTGCCGAATGCCGTGTCTCTCTGGGCAGGTGTCAGATCGCTGATCCAGACCGTGTGGTTCATACCACCGAAGCCCCGGATCGTCTGCCGCACGGCCGACGGGTCGACGATCACAGTGGCAGCCGCCGCGGATGCCCCCACGGCAGGCGTCGCGGCCACGAGAGCCGGTAAGGCACTCATCGTCGCCAGAACGGACCTCCGGCTTGGGAATTCCGGTCCCTTGGCTGCGGATTCATTCTGACGTGACACCATTTATTTCTCCTCCCGAGTGTTTCCTCGACGCAGTGTTGTCATGGATGCCATTTTTCCGCATTGAGTTTTCCCGAGCTTGGGAGCGCTCCCATCGCCATTCGCACGTTAACGGCGTGACTCGCCACCGTCAACCTGCGCCGCCAGTTGGGCGGTCGGCGGCGGCGACCGCACATCTCCAAGGTCACTGCCCCTCCGACACGGGACTGGGGCCGCAGCCGGCAGGGAGGGGATCATGCCTGACCGTCGGAGGTTGTCGCACCTGTGTGCGGCCTGCCGATGGCTGAGAAAAACGCTTGGACGCCGCGGGCGTCGTCACGGGACACTGCGATTTCGGGCCGTGGCGTGGGAAGCATCTGATGGGCTGCCACACGACAACCCAGGGGTGGGATGAAATCATCTGAATCGCGCGAGGTCCCGCCGGGCAGGGGCTCGGTGATCCTCGCGCTTCGTTACTACGGACGGGAGTTGTCCCGGCTCCGGCGGGTGACGGTGCCCGCGATGCTCCTGCCCGCGTTGGGCAATATCGGCATCAACTACATCGCGCCGCTGATCGTCGCGAAGCTCGTAGCCCGAATCGCCGACGACAGCGGTGTCTCGATCGGCTCGACACTGCCCTACGTTCTCGGCTTCGTCGGCGTCCTGCTGCTGGCGGAGTTGCTGTGGCGTATCGGCATACATTGTCTGAACCGCGTTGACGCGCACGGTATCGAACACCTGTATGTGATCGGCATGGACGAGTTGTTCGCCAAGGACGCGGCGTTCTTCCACGACAACTTCGCCGGGTCGCTGACCAAGCGGGTCCTGAGCTTCGCCTCCCGCTTCGAGGAGTTCATCGACACCCTGACGTTCTCGGTCGTGGGCAGCCTCGTACCGCTGGTGTTCGCGTCGGTGGTGCTCTGGAGTTACGACCCGCTGCTCGTTGTCGGGCTCTTGGCGATGATCGCGCTGACGGCGCTGTGTGCGGCGCCCCTCATCCGCCGCCGCCAGAAGCTCGTTGATCAGCGCGAGGAGGCGATCGCCCGGGTGGCGGGGCACGTCGCCGACAGCCTGATGAACATGGACACGGTCCGGGCGTTCGCCGCCGAGGAACGGGAGGCCGCGGAGCATCGGTCCCGCGTCGCGGAGTCGCGGCGGCTCTCGCTGAGGTCGTGGGACTACGGCAATCTGCGCATCGACACGCTGGTCGCGCCGATGTCCGTGCTGACCAACACGCTGGGCCTGCTGCTCGCGGTCGCGCTCGGCGGGGGCAGCCACGGTGTGGAGGCGGTCGTGGTCGCCTTCACGTACTACTCCAACGCGACGCGGATCATGTTCGAGTTCAACCAGATCTACCGCCGTCTGGAGAGCTCGATGACGGAGGCCGCGCAGTTCACCGAACTGCTGCTGACGTCGCCGACCGTGCTCGACCCGGAGTCGCCGGAGCCGCTGCGGTCCGAGGGCGCCGGTGTCCGCTTCGAGAAGGTGGCCTTCGCCCACGCGGGCGCGGAGACACTTTTCGACGGCCTCGACCTGGCTGTGCCCAGCGGGACGAGGGTCGGTCTCGTCGGCCGGTCCGGCGGGGGCAAGACCACGCTCACCCAACTGCTGCTGCGGACGACGGACATCGAAGCCGGCCGGATCCTGATCGGGGGGCAGGACATCAGCAGGCTGCGCCAGGCCGACCTGCGCAGCCTGATCGCCTATGTGCCACAGGACCCGGCGATGTTCCACCGCACACTGCGGGACAACATCGCGTTCGCCCGACCGGACGCCACCGACTCCGACATCCGGCGCGCGGCCGAGGCGGCGCATGTCACGGAGTTCGCCGATGCGCTGCCGGACGGCTTCGACACCATGGTCGGCGAGCGCGGTGTCAAGCTGTCCGGCGGACAGCGCCAGCGGGTCGCTCTGGCCAGGGCGATCCTGCGCGACGCGCCGATCCTGCTGCTCGACGAGGCGACCAGCGCCCTGGACTCCGAGAGCGAGGTCCTCGTCCAGGAGGCGCTGTGGCGGCTCATGGAGGGGCGGACGGCGCTTGTGGTGGCCCACCGGCTGAGCACGGTCGCCGCCATGGACCAGGTCGTCGTCCTCGACCGCGGACGGATCGCCGAGCAGGGCACACACCAGGAACTGCTCGCGTCGGACGGCACCTACGCGAAGCTGTGGCAGCACCAGGTGGGCGGTTTCCTCGATGACAGCCCCGCACCGGCCGACCTGCGCTGAGCCTCGCGTCGGAAGGGCGCCCAACCGGCCTACGAAGACGACTTCCGGGCCGCTGCCGCCCCATGCCATCTGGCCTGATGCGTACACCGCTCCCCCAAGTCCCGTGAACCGGTCAATAAAGTACGTCGGCAGGCGCGTCGGCAGGCGGACCGCGGGGGGGGTGAGGAGGAGCACTGCTGTGGAGGCACGGGCGCACGCCGGGTGGCTGGACGAGTTGCTGCACGAGGTGCGGCGGCAGATGGCCCGGAGGACCGGGGCGGATCCACGGGCGGTTCTCGACTGGCTGAGTCGGCAGATCGACGCCGATATCGCGCTGGTCGGGAGTGCGGGCGCGGTGGAAACGGCCACCGCGCGCTTCCCACGGCAGATCCTGCCCTCGCTCGAACCCACGCTCGCGCGGCTCGCCGGTGGGCAGATGGCCGCGGCCGCCACCGAGGCCGGAGCTCTTCAGGTGCGTTTGGAGGCACTCGGCCCCCGCGCACCACGCCCGGTCCTGGTGGTGGCCGGCACCTCGGCGCCCACCCCCGACGCGGCGTCACTGGTCTCGCACGCAGGGAGCGTCATCGCGCTCCTGGACCGGGCACAGGACGCCGACACCACCTTCCGCGGCTATCAGCACAAGGCGCGACAGCTGCGGTTCGCCGTGTTCAGCGCCCTGCTGGCGGGGGACATCACACTGGCCCGACGGATGACCACCGGCGCCGTCCCGGCGCTGCTGGACGCCCAACGGCTGCGCGTCTATCTGCTGCAATGCACCCCCGAGGACCGTGACCGGCTGGCGCAGATCCACCAGGACGGATCGGGCTATCACGGCACGGGGCTGATGGTGCACTGCCCGGCCTTCAAGGAACACCTCATCTGCCTCGTCGCCGAAGATGCCGACGGGGCCGACGGGGCCGACGGGGCCGACGAGACCGAGGTGGCCGACGGGGCCGACGCCGACCCCGAGACGGCCCACGGTCAGGGCACGGTGCTGCGCCGCCTGGTCCGGGAGAATCCGCACTACGCGCTGGGCATCAGCAGCCCGTACCCGCTGGGCGCCACCGCCGAGGCGTACGGGCAGGCCCTGCACGCCCTTGCCGCGGCGCGTCATACACCCGAACGGGTGGGCGCCTACCTCGGCCGGACACCGCTGGTGCCACTGCTGCCCCACGAAGACGCGGGCACCTGGGCCCGCGCCTTCCTCCGTCCGCTGGGGTCCACGCCGAGGGCCACCCTCGACATCACCCGGCTCGCCGTCACCTTCCCCAGATCCGCCGTGGCCCGGCTGCTGGACATCAGCCGCAACACCGTCTCCCACCACCTCAGGCGGGTGGAGACAACTCTCGGCCTCGACCTGAGCGACGTCCGCACCCGTGCCGCCCTCGACCTGGCCTTCTGCCTGTCCCCCGGGCCGCAGTCGGACGACAGCTTGGGCGGCTCCGGCGGCTCCGGCGGCTCCGGCGGTGCGTACGGGCGGCCGACGCCCACCCTGGACGAACTGCTGCGCACCGAGCCCGCTCACGCATGGGCACGGGAATTCCTCCGCCCGCTCCAGGACACCCGTGGCCGCGATCTGCACACCACCCTGTGCGCCTGGATCGACGCGAACACGGACGCCCAGCGGACCGCCCGCCACTTGGGCCTCAGCCGGAACACCGTCAGGGCCCATCTGCGCGCCGCCGAACACCTGCTCAGCCGCGACCTGCTCACGACCGGTTCCGGAATCCACGACCTGGTGCACGCCCTGCACATCACCGGTCTGCCCTCGGCGGGCTGACTGCGCACCGTGCACATCTCGTGGCCACACGGTGCGCACCGTGCACCGTTGTCCGCCCCGCTGATCCGCTTTAGCGTCACTTCTGCCGCACAGCGCGGGAACGAGGCCCCGGCTCCGACCGTGACGACGGCCTGCATCACCACGTGGGGAGTGATGCAGGCCGTCGCCATACGCTGTCGCGCCTCGCAGGGAGACGGTTCAGGAACACGGGGGTGACGGTGCCGTCACGCCCGTGCTGCCACCCTTCATCGGGGGTGTCGACAGGACACCGAGTTCCTGTCGGCACCGATATGCCGTGGGAGGGTTCCGTCCGATGCCACCGCCAAAGGCTCTCGCGCTGCGGCCAAGGACGGCGAAGACGGCACCTGTCCCCACTCAGGACCGGCCGGAAGTACGCAGCCCCGCAGGACCCCACTTTCCTCCGTCCAATGCGGCGGTGACGGCCGCTTTGGCCGGCGGACACGGGGCCGCGCCGCTTCCGCCTTTATCAGCGCTATCAGCCCCGTTGCCGCCCGTCGGGCAGGATACGGTCGGCAATGGCGCGATCGCGGCGGCTCGATCGGCACCAGTGAACACGCCGGAGGCGGAGCCTGCGCCGGCTGCCGCGGCCTCCGGCGCCGCGCCGGATGTGCAGGCGCGGCCCGGCCCGAGCGCCGATCCGAAGTTCGCGACGCTGAAGAAGGACGTACAGCGCAAGAAGCGGTCGGTGGCGAGCTCCCATCCGCCCCCGAAGGCGGAAGCCGGGGCCGCGCAGGACGCCGCCCGGCCGCCCAAGGACGACGAAGAGGCACAGGGCAAGACCGCCAACGCCGAGAAGATGAACGAGGCCCAGCCGAAGGACTTCGACAAGGACGCGTTCATCAAGGCGGTCGAGAAGGCGATCGCCGAGAAGGCACCGAAGAACCTCGACGAGGCGGACAAGTTCGCCGACTCCGGCAAGGCCGACGAGGTGCGGGCGGAGGTGCACGGCAAGGTCGGCGAGGGCAAGGCGGACTCGGCCGAGCAGATCTCCACGACGACCGCCGCTCCCCCGGACACCTCGGCGGCCGTGCCCAAGAAGGTCGTGCCGATGACCCCGGACCGGCCCCCGGGGACCCCTGGCACGCCGAATCCGGGGAACGCGGTGCCGGACAAACTGCCGCCGTCGGCCACCGACTTGTCCGCCGGCCCCGCACAGGTCGACCGGCAGATGACGGACGCGCAGGTCACCGAGACGCAGTTGAAGAAGTCCAACGAGCCGACGTTCAAGAACGCCCTGGGCGAGAAGAAGGCCGCCGAACAGCACTCCGCGGTGGCTCCCGGCCGGATGCGCGGGCACGAGAAGAAGGAGCTGCGCGCCGCCACCGCGCAGGCCCAGCGGCTCGGCGCCGCCGCCATGGGCGCGATAGGCGCCCAGCGGGTGCGGACCGGGCAGCAGGTCGGTGCGGGCAAGACGGGTGCCAAGGGCCGGGACGAGGAGAAGCGGGCGCAGGTCACGGCGGTCCTGCAAGGGGTCTTCGACACCATGAAGAAGGAAGTCGAGGCGATCCTCGACGGCCTCGACAAGCTGGTCGACGACCAGTTCGGCAGAGAAGAGAAGGCGGCGCGGGACGCGTTCACCGCCGAGCACAAGCGGAAGATGGAGGAGTACAAGGACCGGCGGTACTCGGGCTGGACAGGCAAGGCGCGCTGGGTCAAGGACTTGTTCGCCGGGCTCCCCGCCGAGGCCGACAAGATCTTCGAGGCGGCGCGCGACAACTACGTCCGCCGAATGCGGCAGGTCATCTCCGACGTCGCCGACACCATCGGCAGCGAGCTGAACCGGGCGAAGCGCCGCATCGCCCAGGGCCGGACCGAACTGCAGGCCGCCGTGCGCAAGCTCCCGGCCGACCTGCGGTCCATCGGGCAGCAGGCGGCGGCCGAGTTCAGCGACAAGTTCGACGAGCTCACGCAGTCCGTGGACGACAAGGGCACGCAACTCGTCGACACGCTCGCCACCAAGTACACCGATGCGCTCAAGTCCGTCGACGACGAGATCGCCGCGGAGAAGGAGAAGAACAAGGGCCTCGTGGCCAAGGCCGTGGACGCGGTCAAGTCCGTCATCAACACCATCCTGGAGCTGAAGCGGCTGCTGCTGTCGGTCCTGGCCAAGGCCGCGTCGGCGGTCATGCTGATCCTCAAGGATCCGATCGGCTTCCTGCGCAACCTGGTCTCGGCCGTCGGCGCCGGTCTCAAGCAGTTCCTGGCGAACATCGGACGCCACCTGCAACAGGGCATCATGTCCTGGCTGCTCGGCAAGACCGCCGAGGCGGGCATCGAGCTGCCGTCCAAGTTCGACGCCCAGGGCGTGCTGCGGATGCTCGCCAGTCTGCTCGGGCTGACCTGGCAGAACATCCGCGCCCGGATCGTCCGCAAGGTCCCGAAGATGGAACCGGCGGTCGCGGCGGCCGAGACCGCGGTGCCGCTGGTCGCGGAGGTCCGTAAGCGGGGCGTCGCGGGGATGTGGGACGACCTCAAGACGCGCGTGGGCGACCTGAAGAAGGACCTGCTGGACAAGGTCATCGCCTACGTCACGCCGACCATCGTCGTCGCCGGGATCATGTGGGTGATCTCGCTGCTCAACCCCGCGTCGGCGTTTGTCCGGGCGGTGAAGCTGATCATCGACATCGTGCGCTTCATCGTCACCCAGGCACGCCAGATCATCGAGTTCGTGGGCGCGGTGCTCGACGCGGTCATCGCGATCGCGAGGGGCGGCAGCGGCGGCGTGCCGGGCATGATCGAGCGCGCGCTGGCCCGCTCCATCCCGGTGCTGCTGGGCGTCCTTGCCGCGATCCTGGGGGTGGGCGGGATCGCGGCCCGCGTCAAGCAGATCGTCCAGGCGATGTCCAAGCCGGTGGACCGGGCGGTGGACTGGGTGATCGACAAGATCGTGGGCCTGGTGAAGAAGCTATGGTCCAAGATCAAGTCCGCCTTCGACAGAAAGAAGCCCAAGCCAAAACCGAAGCCCAAGCGCCGGCCGGACCGGAAGCGGCCGGGCAGGCCACGTCGTCGGAGGCGTCCGGACCAGCGGCGACGTCCGGACCGGCGGAGGCCGAAGCGGAAGCGCGACCCGAAGAAGAAGCGTCCCGACAAGCGATCCAAGAAGGACATGCTTCGGGCCCTCGACGCCGCCGTGCGTGACGCGACGCGTCTGCTGAACGCCAAGTCGGCGACGGAGGAGACCATACGGCGAGGGCTTCCGGCCATCAAAGCGCGCCATCGCCTCTCCAGCATCGAACTCGAAAAGTCGGCCCGAAACACCTATTTCATTACGGTCTCCATCAACCCCAAGAAAAAGACCCCGTTCAAGACGCTCTTCCCTTACAAGATCGGCAAGGCTGCGGCGTCGACCGGGCTCACCGATGCCGGCGTGTCGGTCGGCGCCCTGCATGACATCGGCAATCCCATGCGGGAGAAGTACGCGGCCGCCTTCGTCATCAACATGGTGGCGACGCCCAACGAGGTGAAGGCGAAGCCGAGGATCGCCGCACGCTATCTCGAAGAGGCGTGGACCGGCTCCCCCGAAAAGAAGGTGGCCTGGGCCAGGACCGCCGTCATCATCGGCGTCAACTCCGCCGAACGCCTGGACCCGAAGCGTTCGAAGAGTGGCGTCCCCGCGATCTCGCAAGCACTGGGGGCGATCCTGCGCCCGGACAAGCTGCGCATGATCGCGTTCGGCTTCGTCTGGACTCCGGAATGGTTCGATATCAACAGCAAGAAGACCGTTCCGTTCAGCACGGTGAAAAACACGTACGACGGCTTGGACGACACGCACAAGAAGGCCGCACGTGACGAGGAGGGGAAGGGCATCGGCAGCAAGCGGGCGAAGGCGGTGCCGTACGGGCTCCTGCGCGGGCACGTCTTCACGTCCACGCACACCAAGCGCGCGGTCACCGTCCTCAGCAAGGTCAACCAGCAGGTGCAGGTCCTGAGCCAGGACCCCGACGGCGGCGTCCGCGCCCCCAAGGGCCGCGGCGTGCTGGCCGCGTATGACCAGATCCTCCGCACCATCACCGGCGATCCGGTCATGATCGTCGGCGGCTACGACTTCGATGAGCTCAAGTGGGAAGAGGGCGCCCAGGAGAGGGTGGTCCAGCTGACGCAGCTCGCCAACGCGATCGACCGGGCGGTCCGGGCGGCCGTCGCCCGGCACATCCCGGAGATGACGTACCCCACCGAGCCCAACACCCTGGTCAAGGTCTGGGACAAGAATCGCCGGAACGGCGTTTTCCAGATGATGCAGAATCGGGCCGACGAGGCGGCCAAGGACGCGCTTCCCTTTGGTTTCGGCGAAGGGGAAGGGCGCAGTTTCCGCAAGTGGCTGTTGCGTCTCTACGGCAACGCCTTCTCCATCGTCCATGACCAGAGCGCATCCGTCAGCAGCGACGCGAAGCTGAACGACCCCGGTCGCAAACTCGCGGTGCGCGGGCCAGGCGCGCGCAGCAAACGCCACGTGGCGTACGCGATCATGCTGCAGTCGCAGTCGATGGCGAACGCGCAAGTACTGGCCAACGAGCTCTTCCTGGCGAATCAAGGATTGGGCCTCCCGGCCAAGAACTTCGTGCAGATGACAGTCTTCTCTCATGTGGAGGCCGTCGTCAAAATGATGGTCGACAACCCGGACCTGAAGGTGGGCGACCCGAAAATCCAGAAAGCCATCGACGCCATGGAAAAATCGGTCCGGGAATACCTCGGAGAGAAGATCCCGCCGAAGGCAGACCGCAAGTCCGGGGATCAAAGGCTGCACGACATCCTGGTCAGGGCGGAAGCCATGACGCGCGAGATCATCACCGCATTGACGGCAGAGGAACTCAAGAGCGTCTGGCGGAAGCTGTCCCTCCTGCTGAAGGAGGCACAGGCCGAGGCCAAGAAAAACGCGGAAGCGGCGAAGCACAAGAAAGCGGGGAAAAGGTAAGTGGACGAGTCCGCGCTCCGGCAGCTGCGGGCGGAGGCGTCTCGCGCGGACTACGCCTCGATGGCCCGTCTGGCGCACGCCCTGTACGAGAACGGCCTGTCCGTGCCGGAGGTCATGCGCGAGTGCTACGGGGTCGACCTGCCGACGGAGTTCCTGGTACTCGCCGAGGCCGACCTATGGCGTCTCGACCTACTGCTCGTGTGTACCCATCAGCCGTGGTGGCTGGCCGTCCCGCCGACCCGGGGCGGCCCTGTGGCCGCCCCGGATCCACCCACCGGGACGGAGCGAAAGCTCCTCGCGCTCGACCCCGATCTCCTGCCCCTCGGCTACACGCTCGGCACGAACAGCCCACCCTGGGAGAACAAGGAGGTGCTCTGCTACCGGCTCTCCGAGCTCGCCGCAGGTCGGCCGACCGTCTTCAGGCTGCGGGAGAAGTCCACTCGTCGCGACAAGGTGAAGCGGCGAGGCGAATCCCTGATGACGGTGCTGGAGGAACTCCACTTGGAGGAACTGCGCGAGACGGAGCGTCAGATGCGCGACTGGGACGTCGGCGCCGAGGAGGAGCTTGTGGGGGCTGCACGGGAATTGGTCGAGCGGGTCGAGGAGCTGCGGCGCAAGGTGGCGGCACGCGAGGCGCGGTGAGCGGGGCTCGGCCCGTGGAGGCGCCGCCCTCACCCGGCGGGCGTTGTGTCGCGCCGGGGTCTGGCCAGCTGCGGTCTCACCGAGTCGGGGCGTCCTCCCAAGGCGACTTCACCGGCACGAAGAACAGCCGTACAGCCGGGGCCGCCTGCGCGGCCGCTTTGGTTGTGGCTGCGTTGCCGAGCTGGTCCTGGGCAGCGGGCGGTGACATCTTGGCCAGCGCGTGCATGCTGTGGGCCATCGTCGCGTTGCTCACCGGCACCGGCGCCGGAGCCGGCACCTGACGGGTGGCCATCGCCGTTTCCTGGGTGCGCGCCGGTGGGACGGGAGCCACCAGCCGGTGGAGGGAGAGCGGGGGTTCGGTGGGCAGCATCTGGGTCACCCCGGGGTTCCGTCGTCGAGCAGTTGGGCGTGCGAGCCTAGTTCGGTCGGGCGGAGGAGGCGGGCCTCGCGCTGGAACTGCCGGGCTACGCCGCGGACGATGTGGCGCATTCCGATGGTAGCGCTGTCGCCGTCCGCCGCGGCGAGGGCGGCAGTGCGGGCCGCGGAGGTGATGGCGGCGCCGGTCATGTCCAGGCGGGCCAGGGCGTCGAGGTCCACGTCGGAAGCCAGCGGGGCCTGTTCGGGGAAGGCGAGGCGCCACAGTCTGCGGCGTTCGGCGGCGGCCGGGCGGGGGAAGTGGACGACGAAGTGGAAGCGCCGGGTGAACGCCGGGTCGATGTTGTCCTTGAGGTTGCTGGTCAGGATCACCAGGCCGTCGCTGGTCTCCAGGCGCTGCAGCAGATAGCCGACTTCCAGGTTGGCGTACCGGTCGGTGCCGTGCTTCACCTCGCCGCGCTTGCCGAACAGGGCATCGGCCTCGTCGAAGAGCAGCACCGCGTGGCTCTCCTCGGCCTGCCGGAACGCGGTCTCCATGTTCTTCTCCGTCTCCCCCACCCATTTGGAGACGACCTGGGCGAGGTCCACCTTGAGCAGTTCCAGGCCGAGCATGCCGGCGACGATCTCGGCGGACATGGTCTTGCCGGTTCCGGGTTCCCCGGTGAAGAGCGCCTTGACCCCGCCGTGTCCGGCACGGCGGGCGAAGCCCCAGCTTTCGGCGATCCGGGGCCAGGCGCGGAAGGCGGAGGCGATCTCCAGGATCTGGCGGAACTGGACTTTGGGCAGGACCAGGTCGTCGGCGGTGCGCCGGGGCAGGATCGAGTGGACGGCGCTGCCGCTGCGACCGCGGGTGACGGTGGCGATGGCGGGTTCGACGTGGTCGGCGACCGGCTGCGGGTGTCCGTTGCCGGCCAGGCGTGCTCCGGCGTCGGCGACCCGGGCGACGGCGCGCAGTTCGCCGCCGCTCATGCGGTACCGGACGGCGAGGTCTTCGAGGAGGGTTGTGTCCAGGTCCGGGAGCGCGGCCGACCACATCGCCCGGCGGTCGGTGAAACCGGGGACGGGGACGGTGAGTTCGGCGTACGCGCGGGAGGCGAGCAGGCCCGCAGGGCGCCAGGGCTTCAGACCGGTCAGGCACACCGGCACCCGCGAGCGCGGCAGTGCGGCGGACAGCGCGGCGGCGCGGTGCCGCTGTGGCTCGCCGTGCAGATCGTCGGTGGGGATCCACAGCACGGCGCCCAGCGCGGCGGCCGTCCGCAGATCGGCCTGGGGGTCGGCCTCGGGATCGGCGGTCAGGGTCCGCAGCGGCGCTCCCGCGGCACGGGCCAGCGCCTGTACGGCGTCGAGCTGGCCGTCGGGCGGGCAGCCCCACAACCCGGCCAGGTCGATGTCACCGGAGCCCAGCGCACGGCCCAGCCGGATGAGCCGGTCAGAGGACAGATACGGGGACAGTACGCGCGGCTCCGGCGGCGCGACCTCGCCGGGGTCGTGGCCCAGCAGGCCGACGTCGCTGCCCCAGCCCAGCAGGAAGTCCAGCACCCCGGGGCCGAGGACCAGCTCCTGGGCGAGCCCGACCGCGGCCTCGCCGTGCGCGCGCAGCAGACCGTACCGGCGCAGCGGCCCGGCCGGGCCGAGGGCGCGGCGCAGCGCGAGGCGGGCCGCCGAGCCGTGCGCGCCCACGCTCACCAGCAGTTCCACGCTCGGCAGCCGCCGGTTCAGGTTGTCCACGATGTAGGCGTAGATCCGTTCGTAGCCGCGGTCCAGTTCGACCGCCGCGGCCATGAGCAGCGCGTCCTGTTCGGCGCGGGTCAGGCCGAAGCGGGTGGCGAGCGCGTCCAGGGGCAGGGTCGTGCCCTCGGCGGACGCGCGCCGCCTCAGGTCCCGTTCGGCTTCCGGCTCCGTCGGTCGGGGCTCGTACGGCTCGGCCATGGTGTCGGTGAAGGCGTGCACCTCGCCGAGCAGCACATCGACCTGTTCGTCGGTCACGCAGTACGGCGTGAGGTCCGGCCGGGTGAGCCGGGCGGCGAGCCTGGCCTGGCGCTCGACGGCGGCTCTGAGGGCTTGGTGCAGGTCCGCCAGCCTGATCCGCAGATGCTCGACCGCTGGTTCGCCCATGGCTCTCACCCGGCCGAGAAGGTCAGGGTCCGGCCGTTCAGCCAGACCACGTCGGGCACATCGGCGAGCAGACCGCCGCGCAGCAGGTCCGCGTGGCGCCGGCCCATCGGGACGCGTACCCGGACGGCCGCGGGCTCGTATCGCACCGTGGCCTCCAGGTCGGCGAAGCGGCTCAGGGCCGACAGCGGATCCGGGGTCTCGCGGTCGCGCCAGAGCGTCCAGGCGATGGTGGCCAGACCGAGGGTTGCGGCCAGGGTGACCGTACGCTCCAGGCCGCCGTCGGGCGCCAGTGGTACCGCCCGGCGCTCGCCGACCAGCGCGGCGGCCAGGTCCGCGAACCGCTGTGCGTGGGCGGGGAGTTCCGCGGCGAGGCGTACGTCCGGGGCCGTGCCCTCGGCGGTCCACAGCGGTGTGCGCCAGGGCAGCCGCGCCACCGGATCGCCGCGCAGCGGCCGTACGCCGGTCAGGAACAGCACGCCGGCCGCGGCCAGTTCGCGCAGGGTGCCGGGGGGCAGGGGGCCGTCGCAGAGCAGTACGGGCGGGTGCCCGCACGCCTGCCAGTACGGCAGCAGCCCGGCGGCTTGCGCGGCCCAGGCGATCGGGAACATGCCGTGGGCGTCGACAAGGAACAGCCCATGGTCCGTCCCCGTGATCAGGAGCGGATGGGCGGGGTCGTGGCCGCGGCACACCGACAGCGCCAGTACGCCGTCGAGGACCGGGAGCGCGGGGCGCACCTGGCGGGCGAAGGCGGCCAGCCGCTCCTCGGCGACGGGTGGCTGGAGGCCGGCGAAGGCGGCCGCGGCCTCGCTGTCCCGGTCGGCGCGGCGCCAGCCACGTGCGGTCACGCCCAGCACTTTGTAGCCCAGGGCCGCCGCGAACAGCGGTGCCTGGTCGGCCAGTTCGACTCCGGCCAGTGCGGGGCCGATGGCGTCGAGGTATCCGATGCGTGCCAGTGGCCCGGCGAGCAGGAAGGGCAGCGCCGACCACACCCGTACCTCGCCGGTGGTGCGCACCGGGTTGGCCGTACGCACCTCGTCGGTGGTACGCGTCTCCCCCGGCGGCTGATCCGCGGTGTGGTCGTACGGGCCGCCAGGGCCCAGGGACCGCGCCAGCCGTACCGTCTCCTCGCGGTCCGCCGACGCCAGGTAGTCGGCGAGCAGCCGGGGCAGGTCCGCCGCTTCGGCGCCCGCGACCGCGGCGCGCAGCCGCTGGGGCAGTGCCTCGACGGGCCGGGACCGGGCGGCGGCCAGGCCGTGCGGGTCGGCGGGCGGAGGGGCCGCCGCGAGGGCGCGCCCGACGAGTTCGGCGAGCAGCCGTGCGGCCGGGGCCGCCGTGTCGTCGACGCCGAGCACGGCGCGCAGATACGCCCGCACCGACTCGTCCGGCAACAGTGCCAGCAGCGCGTCCAGTTCCCCGCGCTCCGCGAGTTCGGCGAAGAGCACGGCGGCGCTCGGGACGGTCCACGGGTCCGGCGCCGCCGCGAAGGACTCCTCGAGGGACATGGCGTCGGCGCCGGACGCGTCGGCGGGCAGTTCCACCACCGGCACCGGCGCGAAGTGCACCTCGACGGCCGGCCCGCCGCCCGCGGGTCGGCCGGGCCCTCCGGGCCGGCCCGGCCGGACGGTGACGGTAAGCGGCTCGGTGATCTCCACGTCCGGCCCGTCTCCCGCCAGCCGCTCGGCGAAGTGGTCGGCCAGCAACTCGGGCAGGGCATCGACCACCTGGCGGACCAGGCCGCGTGGATCGGGCCCCCAGCTCCACCCACCGCGCCGGACCACCGTCACGGTGCACCGGTGCACCGTGATGTCGCCGGTCTCGCCGGCGGACGGGCCGGCGGACGGCACGGTGGGCGCGGTGGGCGCGCTCATGTCACCGCCGCCTTCTCCAGGTGGCCCGCCCAGCCGGTCGCGAGCACCAGCACCCCGTGCACACTGCCCTTGACGAGGGTCACCGGCAGTTTCGCCTGGGTCTGCTGGGCGGGGATCTCCCCGGCGAGCACATGGGTGTCCTGCTCGTCGGAGACCAGGGCGAGGACGGGGGTGGGGCGGGCCACGGCGACCTTCACGGTGACGGTGAGCCCGTCCTCGGTCAGCGCGATGCCGTCGGTCCACGACGCGAGGCGCACCAGCGCCGGTTTGGGTTTGCCGTCGGACGTCACCTCGACCCCGAAGTCCAACGGCACGGCGAGGGCTGCCGGTTCATCGTCCACGGACGCCACGGCGAGGTCCCTGGCGCTCAGCGGAAGGGTCGCGATACGGCCTGTGCCCAGGGAGACGCGCAGCGGCAGCGCGCGTCCCACCAGTGCGGCCACATCGGGCGGGGCACCGGCCCCGGTCAGGGCCAGCGCGCCCACGACATGGCCGGTGTCGACCGCGTACACCACGGAAAGAGCCATCGTCAGCCACCGCCGTTCGTTGCCGCGACCGTCGCCAGAACGAGGAAGTCGACCGCCCCGGGCTGCTCGACGACCTTGGCCGGGGTCACCAGGGGGTCGTACAGGCGCATGCGGCAGCGGACCCGCCGGTCGCCGTCCACGGTGGCCTCCACCGGGCTGTACAGGGCCGTGTCCGCCAGGGGCGGGGTGCGCGGGGTCAGTTGGACATGGATCACCACGCGGCCGTCGGCGACCTGTTCCGGGGTGACGCCGGACGGCAGCGGCAGCAGCATCCCGTCGGTGGCCGTCCCGGAGGCCACCAGCGTGCTGCCGGCCGGCATCCGGCCGCTGAAGCTGCCCGCGATCGCCAGGTTGCCGTTGGCGGCCACGGTCATCAGCGGAGCGACCGCGCCACCGCCCTGGTAGAGGCCGAAGACAAGGCTCGGCTGGTCACCGCCGGACAGTACGAGCGCGGGCTTGCCCTCCTGGGCCGCCGGGGCCGTCCGCAGGGTCAGCGCACCCGACCGGGCGACGACGGTGTCCGCGCGCACGCCCGCGAAGCGCACCACGACCCCGCGCGCCGTGGTCTCGACGCCGCTGAAGTGTCCGTCGGTCCAGCGGACGTAGCCCAGCAGGATCAGCCAGCGGACGGGCGGATCGGCCGGCGGATCGCCGATCGCGGGCGGCTGCTGCTCCTCGACCAGCCGCTCGTCGCCCAGGCGCCCGAAGAGGATCTGGTACGACTCCTCCACGCGGGTCTTCGTGGCGCTCCCGGAGCAGGAGACCGGCCCGGGGCGCTGGGCCGGTTCCCGGTCGGCGGCGGTGAGGAAGACCGGGTAGGGTTCGTCGGTCGGCTGGTCCGCGCCGTTGACCTCCTCGAAGTCGCTCTCGCGCAGCACGGCCGGCTCGGTGACGACCACCTCGCGGCCGGTCCCGTCGAGGGCGATCCCCGCCGCGACGCTCACCTCGACATGGCGGACCCCGGTCAGCGGGTCGGTACGGGCCTCGGTGGCCAGGCCGAGGCCTTCCACGATGCCCCATTCGTGCAGGTGGCGGGCGTGCCGGGCGGATTGGCCGCGGGCGTGCTCCACGGCGGCCGTCAGGTCCGCGGCGGCCAGCACCTGACCCTCGTGGAAGGCGGGGCGCAGGGGGCCCGTCATGGCGTCTCACCGGACTTCCGGGTACGGGGCGCCCGGGCGCGCTTGGCCGGGGGCTGCGGGGGCTTGGCGGGCTCCTCCGCCCGGCCCGCTGCCTCGTCCGGCGCCTGGTCCGCTCCCTCGTCCGGTGCGCCTTCGAGGTCCGCGAGGCGGGGCCCGAGCCGTTCCGGCAGCTGCTCCGCCAGATGGGTCACCTGCGTCTGTGCGCTGCTCATCTGGGTGCGCAGCCCCTCCAAGGCGGCGGTGAGGTCGGAGACTTGCGTCCGGAGCCGGGCCAGTTCCTGCATGCTGTCGGTGACTTCGCTGGGCGTCGTATAGACCTGTTCGTGCAGCGCCTTGGGCGGCGTCTCGCCGGGTGCGGGGGTCAGCAGCAGGGACAGCATCTCCTCCAGGTCCCCGGTGCGCGGCCAGTCGCCGAGCAGCCCCTCGGCGTATGGGCGCGCCACCGGGCCCTCCGACGGGAGCGTCGGCTTCTGGTACGCCGGGAGGGGCCCGCAGCACACGCGCTCGGCGAGCTCCCGCAGCCGGTAGAGCTTGGGCAGCCACTCGCCGTACGCCGAGCCGCCCGGCAGCACCTGTTCCCGGGTGGCCGAGCAGACCCGTACGACATCGCAGCCGTCCAGCTCCAGATGCGCGAGCAGGACGTCGGTGTCGGCGCTGTCGCCGCACGGCGGGTTCAGGGTGGCGCATGCGGCGTCGGTCAGGAACCGGCTTACCGCGGTGCCCAGTGCCGCGGCCGCCTCCGCGATCTGCTGCACCTCGGCGACGGTCGCCTTCTCGGTGCTGTCCGGCGGCGGGGGCGGCAGCAGCGGCGGTACGTCCACGGCGGCGACCTCCGTGCGCAGCGCGCAGTCGGCGAGGTCGGCGGCCTGGTCGAGCCGGCCGAGCAGCCACTCCCGGATCAGGCCGATGTCCGCGCGGAACTCCACCCGCAGCGCGTGGCCGAGCGGTGTGCCCTGGGCCAGCATGCGCACTTCCAGCGGCGCGTCCGGGTCGCCGCCCTCCGGTACGACGCGGGCCGCGGTCTCGGTGACGACGGCGTGGGCGATGGTGCGGCGCAGCGGGTCCGGCCACACCGCTTCCATGTCGGCGCCCTTGAGCCGTTCGCACGCGGTGCCCAGGACGCCGCGGGCCTCCCGCGCGGTGGCGAGGTCCGGGTAGTCCTTCGCGAGCTGTTCCCGCCCGGCCGGGTCGTAGGTGTCGAACCGGGCGATGGCGGCGGCCAGTGCGCGTACGTGCTCGGTCATCTCGCGGGCCGTCGGCGGGGGCGGCGGGCCCTCCCCGCCCGCGTTCGCGCGCAGCCAGGCGAAGGCGGTGGCGTACCGCCGCGCGTCGGCGGCGTCGAAGCGGAAGGTGCGGCCGGTGCCGAGCGACGCGACGAGGAGGGCGTCGACGTACATGCCGAGCCGCCGGTCGCGGATGCGGGCCCGGTCGGCCCGCGCGAGGTCGCCGATGCTCGCCAGCAGCCGGGTGCCGGGGTTGTGGCGGTGGTCCTCGACGTCGTCGCAGCCGACGACGAAACGGAACCCCTCCTGGATCCTGGAGGGCTCACATCCCGGCGAGGGGCAGGGCTCCTCCGTGGCGTACGGGGCCACCGGCTCGACGGGGGACTCCTGGTAGCGCACATACAGCCCGTAGCGCCGCCCACCATCGTCGTCGCAATCCTCCCCGCAGTCCACGCCGAGCGCGCTGATGCGCCGGTCCCGCACCAGAGCCCGTACGTCGACCCGTTCGGTGCAGGGCACCACGATGTCGTTTCCGGCGCAGTCCAGCGCGTGTCCGGGGTGGACCGCCACAGTTCCGCCGCCGCACGGGTCGCAGCTGACGCCGAGGCCGCAGATGACTCCCGGCCCGTACAGGGACCGGTTGTGCAGTCTGCGCTTCGCCGTCGTGTACTCGACCAGCAGGCTGAGGTCGTCCTCGGTCAGCAGTTGCCCTGCGAAGAAGCGAGGACGTACGAAGGCGGAGGTCGAGGTGGCGTCGCCACCGCAGCCGCATCCGCAGTCTGTTCGCATGATCAGCGCTCCTTCACAAAGAACCAGCTCTCGAACACGTCCCCGCCCGCCCCGGTGCCGGAGGTCCAGGGGCCGATGCCCGAGGGCGGGAGGTGGCAGCCGCCGTGTGCCGCCGCCGGGGTGGCCTCGGCGTCGATGGTCGGTACGCGTCCGCCGACATGGGTGCCGTCGACCGGGCGGCAGCAGCGGTCGAGGATGAACGCGGCACGGACGGTGATCAGTAAGCGGTCGCCGTCCTGCAGCGTCTCGCGCGTGGTCTGGCGATAGCGGAAGCCCTCGGTGAACTCGTCGCACCCGTCGGATTCGGCGTCCGGTTCGGCGAATGCGCCGCCCATGTACCAGGTGGAGGCGTTGCGGCCGCTGCCGCCCTCGATCACCTGGAGCTCCACCACGCCGGGCCGCAGCGTGTCGGACCGTACGTCGGCGGAGAACCGTACGACGAGCCCGCCGTCCTGGTCCTGGGTGCCGAGGAGGGCCTTGGCCTCGTCGATGGTGTAGGTGTGTCCGTGGATCCAGTTGATACCGGTGATCACCGTGGGCAGATGGCGGCCGAACGGACGGCGTACGTTCATATGGATCTGGTCGCGGCGCACCGGTTCGTACCAGTCCACGCAGTCGATCCTGGCCAGCCACAGCACCTTGTGCTCGCACGGCGAGCAGCAGGTGTCACAGCGCTCGTCCACCGGTGGCTCGCAGCCGGTGACCCGTACCTTGTGGCACTCCTCCGTCCAGCCGAACTCGCAGTCGGAGGTGTCCGCGCAGGCGTCGTTGTAGACGGCGCGGGTGGGCTCGACGGGCCGCTCGGCGTACTCGATGCCGACCCAGACGGTGTCGGTGTCCCGTTCGTCGGGGGGCAGCGCCTTCCACAGATCGATCACGCAGCCGCCCCGCACCACGACCTCGTTGCCGTCGCAGTCCACGGCCAGACCGGGGGTGAGCTTCACCTTGGCCCTGCGCCGGGTGTGCTCGGTGCGGTCCGCTTCACCCTCCGCAGGCGCCTCGGCGTCCGGCGGGCAGTCGTCCTCGTCCCGCGGCGCCGGTTCCACATGCAGACCGCACACCACGCCATAGCCGAGCAGACAGCGCATGCGCAGTCTCAACTTCTCGCGATGGTATTCCTGTTCGCGCTGGAAGTCCCGGGCGCCCAGCATCTGGCCGTGGAAGTACCTCAGCCGGCGCAGCGGTGGCGCGTCGAACTCTTCGGTCCTCGATGTCTCTGTCTCCGTCATCGCCCGTCCTCTCACGACACTCGCGTATGCACACCGACGGCGGAGACGACTCCGACGCCCACCCCTCGCCGCAACCCGGCCGGTCCCGGCCTGAGCACCCCGTCGCGGTTCAGCCGCACGGGCTGCGCGCCGCCCAGTACGGGCGCGGGCAGCGGGACGAACGCGGTGTCCACGCCGACCGTGGACCGCGAACCGACCACGAACCCCGCGCCGCCGGTCCGCACCGACCCCACCGTGTGCGCGGGCGCCTGCCGCTCCACCAGCCGCAGCAGCGCCGTCCGGTCCGCCGATCCGGCGGGCAGAAGCACCCGGAACCGGTGTGCGTGCGCGGTGTACGGATCGCTGTCCGGTGCGCCGAAGGCGCGCAGCGGCGCCGCGCCCAGCGCCGAGCCGCCGATCCGGAACCGGCTCGCCGACCGGCCGAACAGCCGCACCGCGCCCAGCCCCTGGCCCCTTCGTGGCTCCGGCTCCGGCCCCTGTCCCTGTCCGGCTTTGCGCAGCTGCGCCCTGCGCCCGGCGGCGGTCGGCCGCCAGTTCGTCGATGACCGGGGCCGCCCCGAACACGATCCGTACCGCCTCCCGCAGCGCCCACGGCGTGCCCCGGCGTCGGTACAGCTCCGGGGCCGCGGCCAGCAGCGCGCGCCGGGTGGGGGCGTCCCAGCCCGCCTCGTACGACAGACCCAGCAGCCCGGCCAGCCAGGGCAGCACCCGGTCCGGGACGCCCGCCGGGTCCAGGAGCGCCGGATACCGCTCGATGACCCGGTCGAGCTGGGCGAGCGTCGCGTCGAACAGCGACAGGAAGCGCTCGGTGAAGTCGTCGGCCGCGGGGTCCTGGCGGAAGGCGGGTGGCAGCAGATCGGCGCTGGTGGCCCGGGGGAAGTCCAGCCGGATCCGGCGGACGACCGGAGTCGCACCGCCGTCGCCCGACAGTCGCAGCCGCAGCCGCAGAAAGCGGCCGGGCGGCTGGTCGACGAGGAAGTCCGTGGCGCCCGGAGCCGACAGCTGCCAGTCGCTCTCCTCGTACCGGCCGTCCTCGCTCACCACGATGTCGACGGCGACCGCCGTCCCGGCGGGCACATCGGCGTCCACACGTACGCGATGCCAGCGGCACCGCGAGATACCGCTGTCGATCAGGGTGGTGACATACGACCCGCTGGTCATATACGCGTCGGTGGCCGGCGGCGCGGCGTCCCGGGGCTGGCCCTGCCAGGTGAAGCAGGTGGTCTGCGGGCCGTCCGGGCCCTTCTCGCTCAGACAGAACCCGTCCTCGCCGGCCGAGGTGAGCGCGGACGGCGGCAGGGCCGCGGCCAGTTCGTCCACGGTGACGGGTCGGAAGGGGCCGCGGTGACCGCCCCGGTGGATCCTGATCCGCCCGTCGTCGTCGGTGAGCAGCCACACGGTCCGCTCCGGTCCGGTGCGCAGCCCGATGACCTCACCGCGCGCGCCGGTACGGAGCACACCGCGGAAGCCGCCCGTCGAGTCGTACCGCCGGAGGTTCGTGCTGCCCTGACAGGCCACCAGAACCTCGTCGTCAGGGGCCAGGGCGGCCCACCGCGGCCGCTCGGCCCGGATCACCCCGGCCAGTTGTCCACCCTCGCGGCGCCACACCAGGACCCGGTCGGACTCCACCACGGCCAGCCGGTGGCCACGGGCGGCGACGGAGACCGGCTCGCGCAGCGCGGCGGGGTCGCAGCCGGGCGGCCAGACGGGTGTGAAGGCGCCGCTGCAGACGTCGCGGCGCAGCAGCCGCCGCTCGTCCGGGACGAGCAGGTACCAGGCGCACGGCCCACACCCCGGCGCGAGCCGTGGGTCGGGGAACCACGGCAGCAGGCTGCCTCTGGTGGGGCCTTCCGGCGCGTCGCCACGGTAGGCGAGCCGGAGGCCGGCCGGATCGTCAAAACCAACGATGCCGACGATGCCGCGGGCACCAGGCTCGGTCGACTCGTCCCAGCCGACGTAGGTGTCGAGGAGACGGAAGGTCGCGGGGTGCGGTGCGCAGGTCATGACGGGTCACCTACCGGGATCAGCAGCGGGCGCTCCGGCCAGACGAGGGTGTGGGGCGGGAGGGCGTGGTCGGTGCAGGGCGGCCGGCGCACTCCGTCGACGGTGAGCGAGAGCCGGGTGACGGCCAGCACCCCGTCGACCGCCAGGAGCCGCCGTACCAGAGCCGTGTGCCGCAGCGCGCCGCCGAACGGCCAGCCCGCGCCGTCCTCCCCGCCGCGCAGCGGATCCAGATAGGTGCGCACCGCGTCGCCCGCCCTCGCCAGGACCGCGGCCCGGTCGAGGTCCGGGTCGAGCGTGACCCAGGACTCCACCGCGACGCGGTGGTACGGGGCGGGGGCGGCGACCACCGTGACCCCGGCGGGGGCGGCCTCGCGCGACAGGAAGTCGGCGACGGCCCGCAGGGTCGCGGCGGTGGGGACCGGCGGTTCGCCGGGGTCGTCCGGCAATACGGGCGGTACGACGAGGACTCCCACGACGCCGGGGATCGGCGCCCCGGCGAAGTCCGGGTGCAGACCCGGTACGCCCCGGGCGCGGGCCACCGACGCACCGGGCGCACGGGTGGCGAGCAGACCGTAGTCGGCCGGGGCCACGGCCCGGCCGCGGGCCCGCAGTTCGCCGACGCCGCGGCGCATGGCGTCGGCGTCGGGCTCCGCGTCCGTTCCGCCGGAGGCCGGGAAGGGGTTGCCGACGCCGGTGACGAACGGCAGCGCGGTCACCACCGCACCCACCGCACCCGCCCGTACGGCGCCGGCGCTGCCGCCGCCCACGCGGTAGCGCACGGCGCGGACGTTGCGGAAGCCCGGTGGGACGGCCGCGCCGTTGACACCGTCCCCGAAGGTCACTTCGCCGCTGTCGTAATCCACCGTGAACACCCGGTCGTCGGCGCCGTACCCGGCCAGGCTCTCCACCTCTCGCCACCGGGACGAGGTTCCGGCTGTGGTGGCGGCCGAGGTGCCGAACACGTCGCCGCCCGCGTCGTCGTCGACCTCGATGACCACCGATCCGGCGAGGATGGGCACCTGACTGAGTTTCATACGGCGCCGCCCGGTCGCCGCGGGGTCCTGGACGGGCTGCAGCGGCTCGTCCCGGATGGTGCGGGCGGCGGTGGCGGCGACCACGTTCAGCCGCAGTCCGGACAGCACCGGCGCCGGTCCGGTGAACGCGCCGTGCGCGATCCGCACGCGCAGCCAGCGCAGCCGGGGCCGGGTGGCGGCCGGGGTGCCCGGCTCCCAGGAGCGCGGCACCCGCAGCTCGACGGTCCCGCTGGCGCTGAGCCCGGCCGTGGAGTCCCGTATCAGCTCGGCGGGTACCAGCCGGGTGCCGTCCAGCACGTCCCAGCGCAGCAGCGGTGCGGGCGGCAGCGGGAGGGGCAGCGCCCCGCCCGAGGCCGTGGGCGCGGGGGGCGCGGCCACGACCACGATGCCCAGCGACAGCCGCGGGTAGGGGCCGGCCGGTCCGGCGAGCCCGATCCACAGCCCGTTGCCGGGCTCCGGGTCCCGGCCGAAGGGCGCGAAGGGACGGCTGGGCCCGGACGGACCCAGCGGCAGCGGCTCCAGCGTTCCGGCCTCCTGGACGGCGAGGTCGCCGAGGGTGGCCGGGGTGGCGTACAGGTCCTGGTCCGTCTCGTAGACGACCTGCCCCGCCGGGGTCTGCGCCGCGCTCTGGAACCCGGCCGGGACGAGTACGGAGGAGCCGTTCGGCGGGTTCACGGTGAACTCCAGGAGCGCTGCCGCCGCCCCGGCCGGGCGCCGTCGCACGCCCGCGATCGCCAGGTGTTCGGCCAGCGCCTTCTCCGGCAGCCGGTTGACGCGGCCGAGTACGGGTTCGGCCTGGGTGCCGAAGAGGCGGACGAGCGCGACGCCCGCGTCCTGGCGGTCGGGGTCGGTCCAGTCCGGGGTGTAGCCCGCGATCCGGCCGCGTACCTCGGCGCGGACCGCCTCGCGGGTGGCGTCGACCAGTTCGGGCCCGCCGCCGGTCGGTCCGGGGCCGGGCACGATCCGCCCGTCGGCTCTCTCCTGTTCCCGAGCGTCCCGCTCCCACCACACGTCGCCGGTCATACCAGCCCCTCCCCCGGTTCGACGGCGGGCACGATCCGGGTGCGGACCGTCCGCAGGACGGGAAGCGCCCCGGCCCCGAGCGGCACCTCGTCGCACGCCTCGAAAGCCCCGTCCGAGTCCACCCCGTCGAGGCCGATCGCCACCGCGGCGATGTCCCCGAGGTCCCCCAGCGCCCGCTGCGCGGCCCGCAGCAGGGCGGAGGGCCGCAGCGGCTGTCCGAACGGCCAGCCGTCCTGGTCCTCACCGCCCACGAGCGGGTCGAGGAAGCGGCGCAGCGCCGCGGTGACCACGGTGGACACGCGGCTGCGGTCGGCCGGGTCGCCGGACAGGTCGACGCGCAGCGTCACTTCGCGATAGCGGGGCGGGCGGACGATGACCTCGGAGGTGAGCAGCCGCGCCTGTGCCAGGCGGGCGGCGACCGCGCACACCATGCCGGGGTCGGGGAGCGGCGCGGCGACGAAGTCCTCGCGGTCGAGGTCGTCCCGGGGCGCCGCCGGGACGATATGGACGCTCACCGCGCCGGGCACCGTGGCACACGGGAAGCCGGGGTGTTCGCCGAGGGACGGGTACGCGCGGGCGACGGCGACGCCCGGGGTCGTACGGGCCAGGGTGACGTAGTCGGCGGCGGTGACCGCGCGGGTCACCTCCCCCAGGGACGCGGCAGCGCGCCGGCGCGCCTCGGTGACCGTCTCCGGGTCCGTGCCGCCTTCGGCCCGTACGAGGTTGGCGGCCGAGACCGCGCCCGGCGGGGCCGGAAGGTCCGGGGCCGCCAGCCAGTTGCCGGTCATACCGCCGTTGCCGCCTCGGCCGCCGCCGGTCGCGTACTCGATCTGCGCGTCCGGGCCGGGGCGGGGGATGCGCCCGGTGAGTCCGTCGCCGAAGACCACCGCGCCCTCGGTCCGGTCGAGTACGAAGATCCGGTCGGCCGGTGCGCCGAAGGTGAAGTCCGGCACCGGCTGCCACTGCTGACCCGCCAGTTGCACGGTCGCCTCCAGCAGGCGGTCGGCGGCGTCCGGGAGGACCAGATGCTGGCCGGGCAGTTTGAGCCACGCGTCGATCTGCTCCTGGAGATCGCTGCCGCGCGCGGTGCGGCGCCTGAGGTGGTGTGCGGCACTGACGTTGACGGCGAGTTGGAGGAGGCGGGGCGGTGCCGCGTAGGTGGCGGCCGGGGTCGACACCAGGAGTCCGGTGTCCCGTGTGGTCCAGCCGGCCGGGGGGTGCAGCCGGACGACACCGGACCGTCTGAGCCCGGCCGTGCCGTCCTCTACTTTCTCGAACGCGCCGGAGACATCCGTGCCCGGCCGGAACCAGGACCAGGTCAGCTCCGCGGGAGGCGGCACATCGGCGACCGCCCCGGGCAGCCATGACGGCGCGGACGCGGCGGGCGCGTCCAGTTCGACAAGCAGGCAGATCGGGCCGGGCGCGGGGTGCGCTCCGGTGAGCGGCAGGGTGAACCGGACCTGTGCCGGGGCACCGTCGCCCGCCAGCAGCGCGACACCGCGGCGGGGGGGCCCGCAGGTCCGCCGTACGGTCGCGATCGGTCCACACGGTGACCTCGCCGTCCTCGGCGAGCGGGAAGACGGCCACGTCGTCCGCGAGGGTGAAGACAATCTGCCCCGCCGGGTCCCGGGTCAGCTCCGTCCCGGCGGGGACGACCGGGACGGCGGTGTCCGCCTGCAGTGCGTCGACGCGCAGCACGGTGGCGGCGGGGCGGGCGGGGAGCGGCGGTTCGAGGCCGAGCAGCCGCAGTACGGCGACGACAAGCGCGTCCGGCACCTGGTCGAGCCAGTACAGCCGCTGTTCGAGGAGGTGGGCGAGGAGTTCGAGGAGGGTGATGCCGGGGTCGACGGGCGCGTGCAGCGTCCAGGTGCCGTCCGATTCGGCGGGGATCCGCCGCCGGATGGCCGCCATCATGTCGGCCCAGGTGAGGTCGTCGAGCTTCGGCGCGGGCAGTGTCATGATGTGCCCCCGGTGAGGCCCGTAAGGCCTGTGAGGCCGGTGTAGAACGGGAACACCAGGTTGGCCTTGGTGTTGCTGCGCCGGATGCGGTAGACGACCGAGACGGTGATCCGCGACTCGTCGGCCGGGTCGGCCTCCGCGCGTACCTCTTCCAGTTCCACTCGCGGCTCGTGGTCACGGACCGCGGTGGCGATCGACTGCTCCAGGTCGCGCAGGTTCTGCACGCTGCCGGGCGCGAACACCAGCTCGTGGGCGCGAGTGCCCAGGTCGGGCCGCATGACCCGCTCGCCGACGCCGGTGAGCAGCAGCGCCCGCAGACAGTGCTCGATGCTCTCCTCGCCGACGGCGTACCCGAGCCGCCCGGACGCGTCGGGCAGGATCGGGAACCGCCAGCCGGTCCCCAGGAACTCCTCGCTCATGCCGTCCTCGCCTTCTTGGCCAGTACGGCGGGGGTCAGCGGCGGGGTCGGCGGGCCGGTCGGCCCGGCGGCGGAGGGGTGGGTGTGCGCATTGAACGCCTGGAGCAGCGCGTTGCCGAGTACGAGCGGTTCGGTGGCGCCGCCGCCGAGGTCGATGGAGGGGGAATCGAGTGTCACCTTCGGGGCCTTGAGGGTGATCTCGCCCTGCGCGGTCACGGTGACGCTGCCGCCCTCGGCCGCGGTGATCCGGATCGCCTTGCCCTGGTCGTCGAGCTCCACCACATGTCCGGCGGCGGAGGTGATCTTCACGGCGGCCTTGGACTGGGTGTCGTCCAGCAGCACTTCGTGGCCGTGCCGGGTCCGGATGAGCTTCTGATCGCGGCCTTCGGTGCGGGCGGTCGGCGGTTTGTCCTCGCCGTTGTAGAGGCCGCCCAGGACGATCGGGTACCGCATGTCCCCGTGGACGAACGCGACCAGCACCTCGTCGCCCTTCTCGGGCACGAACACCGAGCCGTAGCCGCCCCCGGCGTACAGCTGGCTGACCCGGACCCAGTCCGTGACCGTGGTGTCGTCGAACCACGGGAACTTCAGCTTGACCTGGCCTTCGTCATCGCCCTCGTTCTCCACGACGAGCGCTTCGACGACGCCGTAGTAGCGCTTGTCCGTGGAGCGGGCGCGTGGTGTGCCCCTCATGGTCACCGGCCCCCCTGGTGGATCCGCCGTGCGGTGAACTGGGTGAAGAAACCACTGGTGTTGAGGGTGTGCTCGACCCGCTTGACGAAGTACGTGCCCGAGAAGCGGCGGCCGAGGCCGTAGATCTCCAGGTTGTCGCCGGGCCGCAGCTCGGGCAGGCCCGCCACCTTTCCGGTCGCGGTGATGAACTCGTAGGCACGCTCGCGCAACAGGCTGATCGCCAGTTCCCGGGCCTCCTGGTCGCTGCCGACCGGCGCGTCGACCACGACCTCCTGGCGGCCCTGGAGGGTGGACTCGGCGACCTGCGGCCCGCTCTGCCCGTCTGCCGTGTTCTGCCCGGCCGGCAGGTTCTCGGCGGTCGCGGTGAACGCGATCGCCGCTTTGGTACGGGGGTCCCAGCCGCGTACGGTGACTTTGCTGACCTGCTGGGACACCGTCAGCGTCGGGGTGAACTCCATCAGGTTGGGGACCAGCCCCTCGGGCTGGTCGGTGGGGCCGGTGCTCAGCCCCGGTGCGTACGCCAGCCGGTACACCCGGATCGGGCGGCCGTCGCGGCCGTCGGTCGGCTTGATGAAGTACAGCGTGTCCTCGCCGTCCTTCGGGTCCGGCAGGATGTAGCAGTCGAAGTCGAGCCGCTTGGCGCGCTCCAGCAGGAACGTCGCGTCGTCCTGGTTCTTCTGCACCACCAGGTCGTGCGTGGGGCCCTCCCTGGTGACCTCGATGCGCAGATGGTTGCGCTGGGCGATCTGCTCGGCGATGCGCCAGTCCGGCAGATTGCGGTAGATCTTGGTCTCGTTCTCGGTGGGCTTGCGGTCCTTGAGCCGCAGCAGCCCGTCCACCCCGCTGACCTGGACGGTGGGCGAGGCCGCGTCGGTGAACTTCGGGCTGAGCGTGGAGATGGTCCCGGTGGCCACGGTGAGCAGCCGGTCGGCGTAGCCGAGCCGGACCGAGACCCGGCCGCCGAGCCGGAAGCTGGGCGAATCGCTGTGCTTGAACCGCAGGCCCACGTCGTCCCAGTTGTTGAGCGTGAGGTCGAAGCCGGACATCTCGTCGATGTCCCGGTTCACCTTGATGTCGATGATGTCGTTCTTGGTGGACGGGTCCATCTCCAGGCCCTCGATGCGCACATCGAACTCGGGCGCGTACCGGTCGGGCGAGGCGACCTCGGGTGTGGGGGTGCTCATCGCGCGCTCCTCACGCCAGCCGGGGCACGGTCAGCACCCGGCCGGGTCGCAGCTCCCGTGGATCGCTGATGCCGTTGGCCCGCGCCAGCTCCCGCCAGGCGTCGGGCCGCCGGTACAGCGCGGCGGAGATGGAGCTGAGCGTGTCGCCGCGGCGCACCACATAGCTCTTCTCCACCGTGGGCGAGGAGCGCGGGGTCTCGGCGATCTGCGTGGCGGCCGGGCGGAACTCCTTGAGCGAGAGGTCCAGCATGGCCCGCAGCGGCACCCCGTCCGGGCGGAACAGCTGGTAGTTCACGTCCAGCTTCTCCACCACACCGGTGAAGACCTCCTCGTCCCAGACGAACCGGACGACCGGCGGTGCGTGTTCGCGGCTGTCGGGCCGCAGCAGGTTGCGCACCGCGTTGACGTAGGCCTTCCGTACGTTCTCCAGGGTGTCGGAGGTGTCCACCAGCGCCTGGACCGTCAGGGTCTCCGTGCCGCCGCGGACGTACTGCAGGGGCGGTGTCTCCAGGCCGGGGATGGTGATCTCGGCGAATGTGTTGCTCTTGCTCAGCTTGTAGTCGGTGGGGTTGAACCGCAGCGGGATCCGCCGCTGCCGCTCATCGGCGATCACCGGCCGGACGATCTCCAAGCGGGCCCGGGCGGAGCCCTGACGTGCGAAGGACACCGGTGTGACGCTCATGACGCCTCCCCGTCCCCGAAGCGCCGTTCGCTCTCGGTGTGCCTGGCGCGCGCGCACTGGTCCTCGTACAACTTCGCCCATGCCTGGATGTGCTTGTTGAACAGGCGGGTGAACACGGCGCCGTCGTCGCCGTCCACCTGGAACCGGACCTCGAGCTGGTGAATGGTCACCTTCGGCACGCCGGTCACCTCCCTTGACTCAGGCGCGGCAAGGCGTTCGCCGCGGCGTCCTGCAGGACCTTCGTCAGCCCCTCGTGCGCGATCTCCAGCGACTCGATGGCGATCGCGTTCTGCTCCGCGTGCAGGTCCGGGCCGCTCCACTTGGCGGCGAGCCCGCCGTGGAAGGCCCACGCCGCGCCGGGCACCCCGTCCGGGCCGAGCACGATCACCGCGCCGTCGCGGCGGGCGCCCAGCGAATCGGCGAGCCCGGCCTGGTACCAGGCCCACAGCCCCGGGTCGCGCACCACCCCGCGCTTGAGCGTGATCCGGTTCCACGAGTGGCGCAGCGGCAGTTGGTGGACCGAGTCGTTACGGCCGCCCTCCGGGTAGCTCACCACCTCCAGCTGCGCGCCGAGCCCGGTGACCTCCTGGAACGCGCCGGAGGCGGCCAGTGGCAGCAGCAGCGCCTGCGCGGGCGGCAGATACGCGTCGCCGGGGTCGAGGGTGACCAGGAAGCGGTATTTGGGCAGTGGATCCAGGGTCATGCCTCGATCACCTCCAGACCTCGGTCCTGGCCGAGTACGAGACGCAGCCGGATGAACTCCATCGGGACGGCCGGGGCGACCTCGATCTCGCAGACCAGCTGCCCCGGGTCCTGTTCGGGCGGGTTGTTCGTGTCGTCGCACACCACGCGGAACGCCTGCTCGGGCCGGTCGCCGGCGAGCGCCCCGGCCCGGAAGGCCGACAGGAGTACGGAGGTCAGCGCCCGTACCAACGTCAGCCTCAGCTCGGGCGAGTTGACGTCGAACACCAGCGGGCTCGCCACCCGCCGGATGGCGCGCACCAGCAGATGCACCAGTCGGCGGTGCGCGATGTAGCGGGTGCCCGGGTCGGCGGACAGGGTGCGTCCGCCCCACACCATCAGCCCCCGCCCGCGGGTGCAGCGGATCAGGTCGAGCCCCGCGTCGAAGAGCCGGACCTGCTGCGGCTCGGGGTACTCGGCCGCGAGGTCGACCGCCTCCAGGATCACGGCGCCCGCGGGCGTGTGGTGCGCCCCGCGCTCGGCGTCGAGGCGGGCGATGACGCCCAGGACGTGCCCGGACGCCGGGACGGTCCGCAGGGCCTGTCCGTCGGGGGTGCGCAGCGGCGGGTGGTAGACGGCGGCGCAGCCGAGCAGCGCGCTGTCGCCGCCGGCCGCGAGCGAGCCCGCCCAGTCGACCGCCTCGTCCACGGAGGACAGCCGGGGCGGTACGTCCAGGACGGCGAGGCGGTCGTGCAAGGGTGCCACGCTCCGCAGCAGTTCCAGCACCAGCTCGGTGTGCGCGCTGCCGGACAGGTCCGCGCCCAGGTCGGGCAGCGCCACCAGCGCCGGTTCCGGCAGTTCGGCCTGGAGCGTCACGGCGTCCGCGTACTCGCCGCGGGTGGGCGGCGATTCGGCGCCGCCCGTGAGCGTCAGGTCCCAGGACATCGAGATCGGGCCGGGCCGCCCCGGTGGCGGTGGCGGCCCGTCCGGGATCAGCCGGATATAGCGGGATGCGGTCAGCCGGTCGGCCACATCGGCGAGCGGCAGTCCGGCGAAGGTCTCGGGCGCCTCGCCGGGCATCGTGATCCGTACGCCCACGCCGGCCGGCCCGGCGACCGTGCTGGCCTGGTAACGGATCGCGACGCGCCCGCCGTTGGCCCAGGCTCCGGGGCTGGTGGCGACCACCTGGAAGTCCGTGGCGGCCAGGCCGCCGAGCGGACCGGCCGGCCACCGGGTCCGGGCCGTGGTGGCCGGCCCGGACACCCGGAGCACCCAGGCGGTGCGGCCGCCGTTCTCGAAGAAGCCGCGCAGCGCGTACGGGGTGGCGAAGGCGCCGTCCGGCGGGCCGAAGGCGCCCACGACATCGTTCCAGCTCTCCACGCGCACCGGAGTGGCGACCGGGCCCCGGCGGAGCCGGCCCAGGAACGCCGCCACATCCGTGCGCAGCGGCTCGGTGTCCGAACCGCGTGGCCGGTACGTCAGGGATACCCCGGGGAGCGCTTCGCCGACCATGTCAGACGTCGATCTCCAGCTTCTCGACCGCCAGGACAAGGGTCTCCATGGCGATCTCGTTCTTGGTGGCGCTGAGCGTCGGGCCGGTGTACTTGGTCGGCCAGCCGCGGTCGAAGTTCCAGCGCATCGTTTCCTGGCGGTTCTCGTCCAGCAGCACGATCGAGCCGGAGGTGCGCCGCACCTTGCCGTTGAGCGCTTCGACCACCCAGTTCCAGAAACCGACGTGGCCGGTGATGCCGCGTTTGAAGGTGAGGTTGGTGAACTTCTTCAGCCCCGGGATCTTGCGGACGGTGATGTCCTCGCTCCCGGTGCGGTACTCGATCGGCGGAACCTCCAGCTCCAGCCCGCTCACCTCGGTGAAGGACCCGCTCACCGCGACCCCGTCGTCGCTGACGTTGGTCACGATGATCTGGAAGTTATAGGACGCGTATGGATCGTCCCTGGTAACGGGCGGCATGGTGGCCTCTCCTCGGGCGCTCAGGCGAGTTGGGTCTCGCGGGTCTTCTGCTGGATCCGGAAGATCACGAACTCCGCCGGGAAGACCGGCGCGACACCGATGACGCAGATGAGCCGGCCGTTGGCCAGGTCGTCCTCGGTCATCGTGGTGCGGTCGCAGGCGACGAAGAACGCCTCGTCGGGGGTGGTGCCGGCGAGCGCGCCGCTGCGCCAGACCGTGGTGAGGAAGTTGGTGACGGTCTGGCGGACCAGGGCCCACAGCGCCTCGTCGTTCGGCTCGAACACCACCCACTGGGTGCCCTCGTCGATCGACTCCTCCAGGTAGAGGAACAGCCGCCGGACATTGATGTACTTCCATGAGCTGTCCGAGGAGAGCGTGCGGGCGCCCCAGACCCGGTGGCCCATCCCGGGGAAGAACCGCAGCGCGTTGATGCCCTTGGGGTTGAGCAGGTCCTGATGACGCTTGGTGATGTCCTGGGCGATGCCGTCGGTGAGCCGGATGCCCCGGATGACGGCGTTGGCGGGCGCCTTGTGCACCCCCCGCTCCACGTCCACGCGCGCGTAGATCCCGGCCATGTGGCCCGAGGGCGGCACCTCGACATCGCGGCCCGTCGCCGGGTCGCGGGTGACCAGCCACGGGTGGTAGAGCGCCGCGTACTTGGTGTCGAACGGCTCACGGAACGCCTGGACGCCCTCGATGTCCAGGCCGTCCTGCGGGTCGAGGATCGCGAACCGATCCCGCAGCAGCTCGCAGTGGGTGACCAGGGCCGATTCGGCCGTCCCCGACCACACGCCCGGCACCGCGCAGACGGCCACCTCGTCGATGTCCTCCAGCGCGGCGATCCCGGTCCGCTTGCCGCTGCCGCCGTCCTCGCCGACGAAGTCGGCCACGCTCAGGCTCCCGTAGGCGTCGTCCCCGTCCGCCAGCGTCAGCCAGGATCCGACCGCGGGCACGGGGAACTTCGCCGGATCGGTGGACAGCGCCCCCAGAGCCACCGCCCGCACCAGCTGCGAGCGGCCGGCCAGGGTGGTCACCAGGTTCGTCGGCGCGTCGCCGGTGAGCCGGAGGTTGGGGTAGCTCTCCGTCACGACGGCGCCGGACGGGTCGGTGAACCGGGCGTCGACCTGCGCCTCGACCAGGCGCAGCCGATCGGTTTCGAACAGCGTCCCGGGCACGTCCGCGTCGAATGTGACGAGGTCCGCGGCGATCGCCTCGACAGTGCGGATGGTCAGAGTGGTGCCGTCGTCGAGCTGGACGACGGCGCCCTCGTACAGCCGGCTCGCCCCGCCCACCCGCAGCGTCGGCCCCGCCGAGGTGTTGCCCCGGCGCACCCGGCGCACCACCAGCCCCCTGCGCCACGCCTCATGTGCCGTGCCGGACGGCAGGGTCAGCGTGACCTTCCCGTCCGCCGGCTGACCCACCTCGACCTTGAACCGGCCGGAGCCGATCTGCGCCCAGACCTCGGGCGGCAGATCGTCGGGGTCGAGCCCGGCGACCGCGGCGACCTCGACCGTCGCGCTGTCCGCGGCGGCGTCCGCGGCGAGCTGCGTGACGAAGAGCGCGCCCTCCTGCGGATCCGGCAGCACCGGGAGCGCGGCCGAGGCCATCGGCTGGATCCGCACCTGGACCGCGCCGCCCCATGAGCCGGGGCTCACTGCGCTGAACTCCAGCGTCTCCTCCGCGCTGCGCGCCCCGATCTGCACATAGTCACCGCGGCCCGTTCTGACCTCGGCGGTCAGCGCGGCGTCCAGTTCGACGCGGTGGGCGGTCGCGTCGTAGGCGGCGACACCGGCGGTGTGGATCACCTGCTGGTCGTCGCCGCGGAAGAGCTGGATCTGCTGTCCGACACCGGAGAACCCGATCAGATGGCCGAGTTCCAGGCGGGTCGCGCCCTTGGCGGCGTCACGGGCGACCGGGCTCACCAGGCCGTGGCCCAGCACCCCCGAGGCCGGCGTCGCCTGCCTGCTCGCGACCCGCTTGACGTACAGCCGCTGACCGCCGTTGTCGAAGAAGCCCTTGACCGCCAGCGGAAACAGCCACCAGCGGCCGCCTTCCTTCGGGTCGTTCGCCCAGGTGTCCCGGATCAGGGCGTCCGGCTCGGGGAGGAACCCGCCGAACGTGTTCTGGAACTCCAGGAAGTTGGTGACCAGCTTGGGCTTGCCGGTGTACGGACCGCGCACGGTGACCCCGGCCATACCGGCCGTACTGGTGCTCACCCCCGCGATCGGCCGTGGGCCCGCATCGATCTCCTCGATGTAGACCCCGGGGCTCAGATACTCCGCCATGGACGGCTCCTCACTGCTCGCGGATCTCTATGACGTGCCGGCGCTCGATGTCCTGGGGCAGCCGCACGACCAGCGATCCGGACCGGCCCGGCCGTTCGGTGGCCTCCAGTCGGAACGTCTCCTCGACGGCGTGCTCGTCGGCCTTCTCGCCCTCCCACCGCAGGGCCAGCCGGAAGGCGCCCGCGGCGTCGGACAGGGTGCGCTCATGCCATGGCGTCAGATCCCGGCTGGTCCGACCCCGGGCCTCGACCAGCGCATTGGCGATCGGTGTTCGGGTGGTCGCGTCGACCACGGCGCCGTGCACCGTGCGCAGCCCCGGCGGATAGGGGAAGGAGACGCTGGGCAGCAGCCGGACCAGGCGCGGCTCGGTCACCACCGCGGGCGGGTGGGCGTCGTCATACGGGTACACCAGGAACTCGACACCCACCAGATCGGCCGAGTACGGCTGCTCATCGGCCGGGTACAGCGGCTGGTAGCCGGCGGCCGCGAAGCGCGCGCGGTGCCGCCGCGGCCGGGCCGCCCACGGCTCACCGCATCTGCCAAGACCCGGATAGGCGAGGGCGGCGCTGGGGGTGCGCACCGGCACGTCGTCCAGCGGCAGCCAGGCGCCGTCGCCGTCGCCCTCGTCGTCGAATCGGTCCAGCTGGACCGCCACCCCCGCGCTGCGCACCCGCCGCGCGTAGTCGTCGAACGGTATGAACCAGGCCGGGCTGTAGAGCGTCGAACCTGCCAGCGGCATGAAGCGGCTCATGGCATCGCCGCCCCGCTGATGGCCCGGCTGTTCACGGGGCGGACCGCCGTCTCGACGGCGGAGTCCAGGTTGACCACGCGCACCTCGTAGTTCAGCGACAGCCGGTACGGCTTCTGGATCGCGTACCAGACCCAGGACTTCTGGTCCAAGGTGAGCGGGGTCAGGCTGAGGTGCAGCGAGTCGGTGCTCGCCGCCAGGCTGCCGGACAGCTGTACGCCGTCCAGGATCGCGTCGTCGTAGAACGTCTGCAGGGCCCGCCCGAGCATCCGGTGCTGGGTCGCCGGGTCACCGCCCCAGGGGGTGATCAGGTACCGCAGCAGCAGGGCCATCGGCGGCTTGCGGACGTTCGGCGGGTCGGGTGGCTGGGAGCGCACCGGCGGCCGATTGCGCGACGTCGGGTCCTCGGCGATCTCATAGAGGAACACCGTGAGTTTCGGCGGGGGTGTCTGTACCGTCTCGGAGAGATCGTTGAGTTCCGCGATCGGCGGTTCCACCTGGCTGAGCCCGCGCAGGGCCTGGGTCAAGGTCTCCACGATGACCGTCGAGACGTCGGCGATGACGCCGAAGTCACCCATTCGTATCCTCCCCCGGCTCCGGCTCCGCGCTCGAAAGCGTGCATCGGGAGCATGCCGGTCCCGGCGTGGCCGGATCGCGATCCGCGCATCACACGAACGTCACCGACCCGTTTCGCGGTCGGCCGAGACCGGCGATGACGTAACCGGACACGCGCCGACAACGCCGAGGTGACACCGACAAGGCATATTTCCATTTATGGAAATCCCCTCAGACCGGACCGGCGTTCTGATCCTCCGGGTGTGGGTGGAAGACGGCAGGCCGGACGGCTTCCGCGCCCGCATCGTCCGTTCGGGCGGCCCGCACCAGGCGCCCCCCACCGCGGTGAGCGCGGTCGACGACGTACTCAGCGCCGTGCAGGCATGGCTCGACCAGTTGCTCGAACCGGACAGGTGACGATCCCGCGACGTTCCGGTGATGCCCGGCCATATAACGTCGTTTAACCGAAACGCCGGATACACGATCATGTTTTGCTCGTAACATGGCTCCTGGGCATCCCGCTTGTCGGCAGGGGATGGGTCGCTGGAGCCAATATCGCCCCGGGGGGCCGATGAGCGCAGAAGGCCACGTCATCACGTTGAGACTGCTGAAAGGCTTCGCGCTATTGGTCGATCATAAGCGCGTTCCCGTTTCTTCCAGCGCCCAACGCCTCCTCGCGTTCCTGGCCCTGCAGGACATGCCGCGGACCCGTACCTATGTGGCCGGCACGCTGTGGCCGGACGTCACGGCCTCCCGCGCCAACGCCAACCTCCGGTCCTCCTTGTGGCGCGCGACACGCACGGGACATCAGGTCATCGACGCGTCCACACAGGAATTGGCGATCTCCAAACACATCGACGTGGACCTCCACACGGCGGCGCGGCACGCACACTGCCTGCTCGACATGTCGCGCTCGTGCGACGACATCCTGACCGCACAGACCCGGGCGGACCTCTCGGCCGATCTGTTACCCGAGTGGTCCGAGAACGAGTGGGTGCTGATCGAGCAGGAGCAGTACCACGAACTCAGGCTGTACGCCCTGGAGGCGATGACCGAACGGCTCACCGCGGCGGGCCGCCACGGCGAAGCCGTCGCCGCCGGGCTCGCCGCCGTCCGCGCGGAGCCCCTGCGGGAAAGCGCTCATCGCGCCCTCATGAACGCACATCTCACCGCGGGCAACAGAGGCGCGGCTCTGCTGCAGTACGAACAATGCTGCCGCGTTCTGCACGACGAACTGGGCCTGGAGCCCTCCCCGACACTGCGCAACCTGGTCTCGCCTCACACCGAGGCGGGCGCCCTCAGGACCCCGGCGCGTCGGGTCGTCCGCCACCCGGCGAGCGATGCCCTGAGGGACGCCACGGACGAAGCCGAGCGCGTCGCCATCTCCCCGGCCGAGCCGCGCCGCCTCCCAAGATCCAGACGCGCCGGCACCGGCCCGCCCATGCCGTCGCACCCTCAATAGAGAGCCGCCTCGGCGACGAAAGTGACCTATTCGAGCAACACCCAACAAATCGGGCAAAAAATTGATGCCTATAGTATTGCGGGTGTTGTCGCGAATAAACTGCAGAATTAAGTTCGCCGCGTGGCGCCAGCCACGGGCGATACTGTGGGCCACGGCGGGCTTGGTGACCCTCGGATTCCTCATCGCGCTGGAGATTGCCGCGCGTCGCTACACCGGCCAACCGGGGCCGATCACCAATCAGGCGCGAGAGGTGATATTCGCCCCCAAACCGGGGCCGCTGTACGGCGGTATGGCGTTGATGATGGTGGTGCTCACCTGGCGGCAACGGTTCATTGCGCTTGGCGCCGCGATCGGCATCGACATCGTCTTCGTACTGGTGCGGTGGGCGGTCGGCGCCGACGTGCCCGCTGACCATTTCTTCGGCAACGGCGCGTTGTGGGTGATGCTGGGCTGCGGAGTCATCGCGGTCACGCGCCGCACCGGCCGGGAACGTGCCCTGCTGCTGAAGGGCGTCGGTCTTGGCCTGCTGCTGGTGGCCGGCCGTAAGACCGGCGACACCTGGCTCCTGATCACGGCGAAGACCCGCCCGACCGTGCTCGACGAGTACGTGGCAACCGCCGATCACGCGCTGGGCAACCCGTCGTGGCTGGCAGGCCGGATTCTCAGGGCCACCGAGCCGATCGGCACCCACCTTCTCGACTGGGTCTACGGTGAGCTCGCGGTGGCCGCGATCGTCGTCGCGCTGTACCAGCTGCGCAACGTGGCGGTCGAGCGCCGCTTCCCCAGACACCATCTGCTGCGCACCTTTCTGGTGATCGGCCTCCTCGGGCCGGCCATCTACATGATCTTCCCGGTGGTCGGACCGATCTTCGCCTACGGCCCGGGCACCTCCGGCACCGGCGGTCTGCAGTGGGCGGTGGCCAACCTGTGGCCGAACACGCTGCCACCGATCAAACCCCCGCACCCGGTGCCGTACGACGGGATCACCCCCCGCAACTGCATGCCCAGCCTGCACACGGCGTGGGCTCTCGCGATCTTCATTCATTCCCGCAAGGGCCCATGGTTTCTGCGATTCGCCGGCGCGTTCTGGCTCATTGCCACGCTCGGCGCGACGCTGGGCTTCGGCTACCACTACGGCGTGGATCTCGTCGCGGGTGTGGTGTTCGCGCTCACGATCGAGGCGGCTCTGCGCACGTTCGACCGTGGCTGGGACCGGTCAGGACTTCAGCTGGTCGCCTACGGCACAACGGTCTTCGCCGCGCTCCTGGTGTTGTACCGCTATCTGCCGATGGAGATGGCCACGCATCCGTGGGTGTTCGGACCACTTCTCATTCTGGCGATGGCCTCAGTGATCTACGGCTATGTACGGACCACCAAACGGTGGGAACCGACGTCCGCACCAGCGCGGCAACCGGAACCGCAACCCGAACTGGTCTGAGTCATGTGGCCGCCGGCCCGCCCGGTGTGGCCCGGCCGTAGGGGCCGGGCCACGGGCAGCGCGGGCCGGGGTCAGGTGGCTTCCAGGGCCGGGTCGGCTACGCCCGCCCTGATGGTGGCCGAGGGCCGGCGCCGAAGGCGGGCGCGAGGTGCTGGGTGTCGAAGGGCCACTCTCCGCTATCGCATCTGGCGCCGCACCAGTTCGTGCAGCTTTCCGCCCGGGACGGCCATCAGCTCGGCCGGGGCGCCCTGCTCCACGATGCGGCCGCCCTCCATGACCAGGACGCGGTCGGCGTCCATGACGGTGGACAGCCGGTGTGCGATCACCAGTCGGCTGGCGTTGAGGCGGCGGGTGCTGTCGATGACGATGCGCTGGGTTTCGTTGTCCAGGGCGCTGGTGGCCTCGTCGAAGAAGAGGACGCGCGGACGGCGGATCAGAGCCTGGGCGATCATCAACCGCTGCCGCTGGCCACCGGAGATGGCGCCGCTGCCGGAGATCATGGTCTGGAGCCCCATGGGCATCTGGCCGATGTCCTCGGCCAGCCCCGCCAGCTCGGCGGCCGCCATGGCTTCCTCGGGGGTGAACGGCTCGGCGCCGCGGATGCAGTCGAGCACCGTTCCGCCGAGGGGTTGGGCGTTCTGCAGGACCACTCCGCACTGGCGGCGGACCGCCGCCTGGTCGAGGGCGGCGAGGTCCTGGCCGTCGTAGAGGACGCTGCCGGACACCGGCCGTTCGAAGCCGATGAGCAGCCGGAGCAGGGTGGACTTTCCGCAGCCGCTCGGGCCGACGACGGCCACGAATTCGCCCGGCCGGATCTCCAGTGAGACGTCGTCGAGCACCAGCGGTCCGTCGTCGCCGTAGCGGAAGGTGAGGTTTCTGGCCCTGAGATCGCCGGAGAGCACACCCGGTGGGGCGCTGCCGCCGCGGACCTCCGGCGGTTCGTCCAGGATCGGCTTGACCTGCTCGAACAGGGGGAGCACGGCGACCACCGAGACCAGGGCGTTGGTGAGCTGGGTGAGCGAGGTGAGCAGCATGGTCACGGAGGTGTTGAAGGTCAGGAACGCGCCCGCCGACATGCTCCCCCGCGCCGGACCGGCCAGCAGCATGAACACGATGAGCGAGACCAGCGGAAGGTAGACCGCGTCCAGCACCTGGGTGAGGTTCTTGATGCGCCCGGTGCGCTGATGCAGATCGCGGGAGTGGGCGAAGCCTCGGGCCCATGCCGCGTACGCGAAGTTCTCGGCCGCGGCGACGCGCAGCTTGGGGAGGCCGCGCAGGACCTGGAACGCCTGGTTGTTGAGCTTGTTCTCGCTCTCCACCAGCCGCCGCTGCCAGCGCACCTGCCACAGCCCCATGCCCAGGAAGACCCCGGAGACCACCAGCAGCATGGCGACCACCGCGAGCGCCAGGGAGGCGTTGTAGTACAGCAGCAGGGCGAGGTTCATCGCGCCCACGGTGCCGGCCTGGAACACCGTCGGCGCGATCCCGGACAGCACCCGGCGCATGGCGCTGATGCCCAGCGCCGCGCTCGCCAGCTCCCCGGTGGAGCGCCGGGCGAAGAAGGTGGTGGGCAGCCGCAGCAGCCGGTCCCATACGGCGGGCTGGAGGGTGCTCTCCAGCCGCCCTTCCAGCCGCAGCAGGGTGAGGTTCTGCAGCAGCATGAAGGCGGCCGCGACAACGCTGGATACGATCAGGGCCAGGGCGATCTGGACGATGGGGCTCTTCTCGGCGCGGGGCACGAATCCGCCGAGCACCTGTCCGGTGGCCAGCGGCACCAGCGCGCCGAGCGCCACCGTCACCAGCCCGCTGATCAGGAGGTTGCGGGCGTCGCCGGCGGCGCCCCGGGCGCTGAAGCGCATCAGCCGCCACATCGTCATCGGCCGGTCGGGCAGCGGCCGGTAGAACATCAGGGCCCGCGGTTCGAACTCCTCCGCGTTGCTCGCGCCGACGCGGATCCGCATGCCGGAGACGGGGTTGAGCGCTTCGTACCCGCCGCGCCGCCACAGCAGTGCCACCGGGGCCCCTGACTTGGCGCGGTAGCCCACCAGCGGTCCGGTGTCCTCCCGCCACCAGCGGCCCTCCAGCCGGACGGCACGGGTGCGGATCCGGGCGTGTGCGGCGATGCGCTCCACCGGGTCCGTACGGCCGTCGGCGGCGCGGCCCCTCGGCGGTCCGGGCAGGGTGATCCCGGCGGCCTCCGCCACTTCGCGGCACACCGCGTGCACGGCGTCGTCGGTGTTCTCCTCCGACGGCCGCCGATCGCGCCGCGGCCCTCCGATGGAGGCGATCAGCGCCTGGTCGGCGCGGGAGCGCATGGCTTCACCGGCTCGGATCCCGGCCGCCGTGCGGTCCGCGTGGGCCCGCTCCACGGTGTCGATCCAGCGGTCCACGGCGGTGCCGAGCCGGTACTGCTGGTTGACCATCCGCTGCCACAGCGCGCCGTCGATCAGCAGATCACCGGCGGCCTGGGCGCTGTACTCGGCGCCGTAGCGCACACTGCCGGGCGGCACCGGGAGCCAGAGCAGGTCCTCGTCCGCCGCGTCCGTGTCGGGCGCGGCCCCGCCGTCCAGCAGGGCCTGGAAGAGCACGCCGAGGCTGCGGCTCACCCCGAGCGCCACGGCGTGCTCCAGCGGCGTCGGCGGGGTGTCCTGGAACACGCCACCGCCCCCGTACATGCCGTATGTGCCGTATGTGCCGTATGGGCCGTACGGATCGTCGGCGTGGCCCGTGCCGTACGACGCGTCGTACGTGTCGTACGCCTCCGGCCGGTACAGCTCGCGCAGCGGGATGCGGCGCACCAGGCAGTCCTGCGAGGGGCGGCCCAGCAGGGTGTGCAGCGGACCGTCGACCGGGCCCGGGAGCGCCGCGCCCGTCTCCAGCCGGCCGAGGAAATGCCACTGCCCCTCTTCGGCGGCGTCGACCGCGAACAGGTCCAGGGCCCCCGCGGCCACCAGCCAGAGCACCTGCGGGCCCTCCAGCGGGAGCCTGCGCAGTCCGGCGCAGTCGACGGGCGTGCCGAGGGCGCCGAGCGCCTGGAGCACCGCGTCGCCGCCGTCCGCGGCCACCGGCGCGGCCGGGTGAACGGACGCCAT

Protein sequences of DBSCAN-SWA_2

>NC_016582|534066:599853|556714_557392_-|WP_014173079.1|DBSCAN-SWA
MAGSTTASAKAQLYDAFAASGKALASGKRLELLDLLAQGERTVDALAKAAGLNLTTASAHLQTLKQAGFVATRREGVRIHYRLAGDDVAQLFALLRKVAEAHQAAVPAARDAYLGEDGAVEVGHEELRARVAAGDVVVLDVRPAEEYRAGHIPGAVSIPIDELVRRIGELPEETEIVVYCRGEYCVLAYDAVRLLTDLGRRAVRLNDGMLEWRLAELPVDSGGLA
>NC_016582|534066:599853|586951_587623_-|WP_014173099.1|DBSCAN-SWA
MSVTPVSFARQGSARARLEIVRPVIADERQRRIPLRFNPTDYKLSKSNTFAEITIPGLETPPLQYVRGGTETLTVQALVDTSDTLENVRKAYVNAVRNLLRPDSREHAPPVVRFVWDEEVFTGVVEKLDVNYQLFRPDGVPLRAMLDLSLKEFRPAATQIAETPRSSPTVEKSYVVRRGDTLSSISAALYRRPDAWRELARANGISDPRELRPGRVLTVPRLA
>NC_016582|534066:599853|587619_587802_-|WP_179285154.1|DBSCAN-SWA
MPKVTIHQLEVRFQVDGDDGAVFTRLFNKHIQAWAKLYEDQCARARHTESERRFGDGEAS
>NC_016582|534066:599853|546381_547440_-|WP_014173070.1|DBSCAN-SWA
MRLPYRPPPTPETTGDTALEIRGLRVEFSEPGHASATPAVDGLDLTVRRGEIVALVGESGSGKTMTALSAIGLLPPGARVTGGRITLGEEDLATLPPKRMNRVRGHRLAMLFQQPKAMLDPTCTVGSQVAEPLRLHRGLSRRQARARVVELLRDVGIPEPERRASAYAHQLSGGMAQRVMIAAALAADPAMMIADEPTTALDATVQAQILRLLRHKQRESGMAVLLITHDLTIVTSIADRVAVMYAGRVVEEGSVREVFDAPEHPYTRALLKASLLQSEEGKLFAIPGSATQSRALDHGCRFQPRCPLSQDLGIAGRCSGAEPPLHTCGGEHRCRCWASEHGTELRGEAVGV
>NC_016582|534066:599853|594432_595323_+|WP_055413837.1|DBSCAN-SWA
MSAEGHVITLRLLKGFALLVDHKRVPVSSSAQRLLAFLALQDMPRTRTYVAGTLWPDVTASRANANLRSSLWRATRTGHQVIDASTQELAISKHIDVDLHTAARHAHCLLDMSRSCDDILTAQTRADLSADLLPEWSENEWVLIEQEQYHELRLYALEAMTERLTAAGRHGEAVAAGLAAVRAEPLRESAHRALMNAHLTAGNRGAALLQYEQCCRVLHDELGLEPSPTLRNLVSPHTEAGALRTPARRVVRHPASDALRDATDEAERVAISPAEPRRLPRSRRAGTGPPMPSHPQ
>NC_016582|534066:599853|585759_586941_-|WP_014173098.1|DBSCAN-SWA
MSTPTPEVASPDRYAPEFDVRIEGLEMDPSTKNDIIDIKVNRDIDEMSGFDLTLNNWDDVGLRFKHSDSPSFRLGGRVSVRLGYADRLLTVATGTISTLSPKFTDAASPTVQVSGVDGLLRLKDRKPTENETKIYRNLPDWRIAEQIAQRNHLRIEVTREGPTHDLVVQKNQDDATFLLERAKRLDFDCYILPDPKDGEDTLYFIKPTDGRDGRPIRVYRLAYAPGLSTGPTDQPEGLVPNLMEFTPTLTVSQQVSKVTVRGWDPRTKAAIAFTATAENLPAGQNTADGQSGPQVAESTLQGRQEVVVDAPVGSDQEARELAISLLRERAYEFITATGKVAGLPELRPGDNLEIYGLGRRFSGTYFVKRVEHTLNTSGFFTQFTARRIHQGGR
>NC_016582|534066:599853|596937_599853_-|WP_014173110.1|bacteriocin|DBSCAN-SWA
MASVHPAAPVAADGGDAVLQALGALGTPVDCAGLRRLPLEGPQVLWLVAAGALDLFAVDAAEEGQWHFLGRLETGAALPGPVDGPLHTLLGRPSQDCLVRRIPLRELYRPEAYDTYDASYGTGHADDPYGPYGTYGTYGMYGGGGVFQDTPPTPLEHAVALGVSRSLGVLFQALLDGGAAPDTDAADEDLLWLPVPPGSVRYGAEYSAQAAGDLLIDGALWQRMVNQQYRLGTAVDRWIDTVERAHADRTAAGIRAGEAMRSRADQALIASIGGPRRDRRPSEENTDDAVHAVCREVAEAAGITLPGPPRGRAADGRTDPVERIAAHARIRTRAVRLEGRWWREDTGPLVGYRAKSGAPVALLWRRGGYEALNPVSGMRIRVGASNAEEFEPRALMFYRPLPDRPMTMWRLMRFSARGAAGDARNLLISGLVTVALGALVPLATGQVLGGFVPRAEKSPIVQIALALIVSSVVAAAFMLLQNLTLLRLEGRLESTLQPAVWDRLLRLPTTFFARRSTGELASAALGISAMRRVLSGIAPTVFQAGTVGAMNLALLLYYNASLALAVVAMLLVVSGVFLGMGLWQVRWQRRLVESENKLNNQAFQVLRGLPKLRVAAAENFAYAAWARGFAHSRDLHQRTGRIKNLTQVLDAVYLPLVSLIVFMLLAGPARGSMSAGAFLTFNTSVTMLLTSLTQLTNALVSVVAVLPLFEQVKPILDEPPEVRGGSAPPGVLSGDLRARNLTFRYGDDGPLVLDDVSLEIRPGEFVAVVGPSGCGKSTLLRLLIGFERPVSGSVLYDGQDLAALDQAAVRRQCGVVLQNAQPLGGTVLDCIRGAEPFTPEEAMAAAELAGLAEDIGQMPMGLQTMISGSGAISGGQRQRLMIAQALIRRPRVLFFDEATSALDNETQRIVIDSTRRLNASRLVIAHRLSTVMDADRVLVMEGGRIVEQGAPAELMAVPGGKLHELVRRQMR
>NC_016582|534066:599853|571856_573719_-|WP_014173088.1|DBSCAN-SWA
MSAPTAPTVPSAGPSAGETGDITVHRCTVTVVRRGGWSWGPDPRGLVRQVVDALPELLADHFAERLAGDGPDVEITEPLTVTVRPGRPGGPGRPAGGGPAVEVHFAPVPVVELPADASGADAMSLEESFAAAPDPWTVPSAAVLFAELAERGELDALLALLPDESVRAYLRAVLGVDDTAAPAARLLAELVGRALAAAPPPADPHGLAAARSRPVEALPQRLRAAVAGAEAADLPRLLADYLASADREETVRLARSLGPGGPYDHTADQPPGETRTTDEVRTANPVRTTGEVRVWSALPFLLAGPLARIGYLDAIGPALAGVELADQAPLFAAALGYKVLGVTARGWRRADRDSEAAAAFAGLQPPVAEERLAAFARQVRPALPVLDGVLALSVCRGHDPAHPLLITGTDHGLFLVDAHGMFPIAWAAQAAGLLPYWQACGHPPVLLCDGPLPPGTLRELAAAGVLFLTGVRPLRGDPVARLPWRTPLWTAEGTAPDVRLAAELPAHAQRFADLAAALVGERRAVPLAPDGGLERTVTLAATLGLATIAWTLWRDRETPDPLSALSRFADLEATVRYEPAAVRVRVPMGRRHADLLRGGLLADVPDVVWLNGRTLTFSAG
>NC_016582|534066:599853|543866_545345_-|WP_014173068.1|DBSCAN-SWA
MTTVETAPATPLTWRPPAGALWSGRWVDGASTMPVHDPEDGRLLGHVTDTSPTEVDQAVTGVATAVASGASGKSWPPWKRREALEEAAALVLRRRERLAEVISREGCKTLREANGEVSRAAETLRLSARQTDRLTGETLPFSDTSRGEGRLGWYTREPVGVVAAITPFNDPLNLVAHKVGPALAGGNGVVLKPAEATPLTALAFAEILLDAGVPAGRLAVVPGTGSGAGHALVSHPLVDLVSFTGGHRTGNAVASAAGAKKTLMELGGNNAVLVLDDADTPAAAQAVVAGAFGVAGQNCLSVQRVFVAARIAAPFLRHVIAATEELRVGRKADPRTDIGPLISEREARRVEGWVQEARESGAVVHTGGRRDGAFHWPTVLTDVPADAKVMTEEIFGPVLVVEPIDTVDEAVARANDTRYGLQAGVFTTALDTALDIAERLRVGAVMINDSSDFRIDAMPFGGPKRSGVGREGVRYAVEAMTEPKVVAVRRGA
>NC_016582|534066:599853|569437_569731_-|WP_043488642.1|DBSCAN-SWA
MLPTEPPLSLHRLVAPVPPARTQETAMATRQVPAPAPVPVSNATMAHSMHALAKMSPPAAQDQLGNAATTKAAAQAAPAVRLFFVPVKSPWEDAPTR
>NC_016582|534066:599853|548138_549044_-|WP_014173072.1|DBSCAN-SWA
MALSSSLSRDPVPSTAPRRLAHLTATGLRAVTGRHWTLRIGAVVLALVLTVLLLTPWIAPYDPAHQDLGQRLSGPGAHHLLGTDQLGRDILSRLMYGGRFSVSIAAVTLLLSAVIGTVIGAFSARRGGIVDEVVMRTTDLLISIPDVIVALFLIAAFGTGYGMLIAALTIVGWTPFARLMRGLALEINSREYIEAAEALGCSKVFIVFRHVIPNALRPVLSLGFLRFGHKLITVGGLSYVGLGVQPPDSDWGAMLLDAQPYMQRLPLLVIAPGAAIFVTALSVTLIGHGMELKRKRRTDAS
>NC_016582|534066:599853|549030_549978_-|WP_014173073.1|DBSCAN-SWA
MVRFIVRRLLVLLITLLAVSAATFAIPYASGGDPVRTILRSRVSDQALDPSAIAALRSELGLDRPILVQYLSWLGRAVRGDFGMSFTSRTPVDQLLGTAIGVSGTLAVIAIGLAFLAALPLGTLAAMRPGKRVDNGVTLLTQSFVAVPEYWLAPILVLVFSRYLGWLPSAGWRDPTSIILPALTLALRPMAYFTQVTRAAMSDVLASPYMTAARSRGLSGGQALLRHGLRNALLPVMTLFSLWFAGLLGGSVVVEVIFAIPGMGRLVYSAVVNHDVPLIQGGILCTVALAVLITTVTDLLYALINPAVRVRDGAV
>NC_016582|534066:599853|588322_589816_-|WP_014173102.1|tail|DBSCAN-SWA
MVGEALPGVSLTYRPRGSDTEPLRTDVAAFLGRLRRGPVATPVRVESWNDVVGAFGPPDGAFATPYALRGFFENGGRTAWVLRVSGPATTARTRWPAGPLGGLAATDFQVVATSPGAWANGGRVAIRYQASTVAGPAGVGVRITMPGEAPETFAGLPLADVADRLTASRYIRLIPDGPPPPPGRPGPISMSWDLTLTGGAESPPTRGEYADAVTLQAELPEPALVALPDLGADLSGSAHTELVLELLRSVAPLHDRLAVLDVPPRLSSVDEAVDWAGSLAAGGDSALLGCAAVYHPPLRTPDGQALRTVPASGHVLGVIARLDAERGAHHTPAGAVILEAVDLAAEYPEPQQVRLFDAGLDLIRCTRGRGLMVWGGRTLSADPGTRYIAHRRLVHLLVRAIRRVASPLVFDVNSPELRLTLVRALTSVLLSAFRAGALAGDRPEQAFRVVCDDTNNPPEQDPGQLVCEIEVAPAVPMEFIRLRLVLGQDRGLEVIEA
>NC_016582|534066:599853|560212_562027_+|WP_086013631.1|DBSCAN-SWA
MKSSESREVPPGRGSVILALRYYGRELSRLRRVTVPAMLLPALGNIGINYIAPLIVAKLVARIADDSGVSIGSTLPYVLGFVGVLLLAELLWRIGIHCLNRVDAHGIEHLYVIGMDELFAKDAAFFHDNFAGSLTKRVLSFASRFEEFIDTLTFSVVGSLVPLVFASVVLWSYDPLLVVGLLAMIALTALCAAPLIRRRQKLVDQREEAIARVAGHVADSLMNMDTVRAFAAEEREAAEHRSRVAESRRLSLRSWDYGNLRIDTLVAPMSVLTNTLGLLLAVALGGGSHGVEAVVVAFTYYSNATRIMFEFNQIYRRLESSMTEAAQFTELLLTSPTVLDPESPEPLRSEGAGVRFEKVAFAHAGAETLFDGLDLAVPSGTRVGLVGRSGGGKTTLTQLLLRTTDIEAGRILIGGQDISRLRQADLRSLIAYVPQDPAMFHRTLRDNIAFARPDATDSDIRRAAEAAHVTEFADALPDGFDTMVGERGVKLSGGQRQRVALARAILRDAPILLLDEATSALDSESEVLVQEALWRLMEGRTALVVAHRLSTVAAMDQVVVLDRGRIAEQGTHQELLASDGTYAKLWQHQVGGFLDDSPAPADLR
>NC_016582|534066:599853|541328_542501_-|WP_014173065.1|DBSCAN-SWA
MSFSAFRTVPTSADVVIIGGGVMGASTAFHLAEAGVHNIVVVERGDLCCGSSGKPIGGVRAQFSDPLNIELGSRSLRAYQEFPHRPGADIRLDTVGYLFLLDSEQQVSDFETGVELQNSLDVPSRMISPSEARRLCPYISTDGLMAAAYSPADGHARPGLVVQGYVRAAARAGVTFATHTAVSGIHTAGDRVSGVHTGHGSIACSTVICTAGAWSAQIGDMAGINLPIRPVRRQLAFTAPLAPPAPRIPFTIDFASSGYFHNSDDGLLFGLADPDQEDGFDTTWTPEWLELFRTVARHRAPALADMETVSGWAGLYENTPDHNALIGRSGELPNFLYAAGFSGHGFLQAPAIGEVMRDLYLEREPFTDISPLSADRFRDGADFRPEAHVV
>NC_016582|534066:599853|542637_543318_+|WP_014173066.1|DBSCAN-SWA
MAKRAVHRRARKILGEDPVALVWCEIHKPIPTPPEDVHRASGKKRLKPGRHWLRYIGAVVFFFVVIPMMLIDGLDRLLQGRRRRGPRAGEPQTPPEDRPAASRRGPARDRRQDPTNGIFDGDWNLAAGQLLLRWYGHSPNPKRLVMLAHDRVCIATSPRRRLSPTKADDFRTVVEFPLDQVRVEGEAGQPRGFATFRLRFTDGSWLEVGRLGEPEDADHFLRTISG
>NC_016582|534066:599853|584642_585065_-|WP_014173096.1|DBSCAN-SWA
MSEEFLGTGWRFPILPDASGRLGYAVGEESIEHCLRALLLTGVGERVMRPDLGTRAHELVFAPGSVQNLRDLEQSIATAVRDHEPRVELEEVRAEADPADESRITVSVVYRIRRSNTKANLVFPFYTGLTGLTGLTGGTS
>NC_016582|534066:599853|575381_577397_-|WP_014173091.1|DBSCAN-SWA
MRTDCGCGCGGDATSTSAFVRPRFFAGQLLTEDDLSLLVEYTTAKRRLHNRSLYGPGVICGLGVSCDPCGGGTVAVHPGHALDCAGNDIVVPCTERVDVRALVRDRRISALGVDCGEDCDDDGGRRYGLYVRYQESPVEPVAPYATEEPCPSPGCEPSRIQEGFRFVVGCDDVEDHRHNPGTRLLASIGDLARADRARIRDRRLGMYVDALLVASLGTGRTFRFDAADARRYATAFAWLRANAGGEGPPPPPTAREMTEHVRALAAAIARFDTYDPAGREQLAKDYPDLATAREARGVLGTACERLKGADMEAVWPDPLRRTIAHAVVTETAARVVPEGGDPDAPLEVRMLAQGTPLGHALRVEFRADIGLIREWLLGRLDQAADLADCALRTEVAAVDVPPLLPPPPPDSTEKATVAEVQQIAEAAAALGTAVSRFLTDAACATLNPPCGDSADTDVLLAHLELDGCDVVRVCSATREQVLPGGSAYGEWLPKLYRLRELAERVCCGPLPAYQKPTLPSEGPVARPYAEGLLGDWPRTGDLEEMLSLLLTPAPGETPPKALHEQVYTTPSEVTDSMQELARLRTQVSDLTAALEGLRTQMSSAQTQVTHLAEQLPERLGPRLADLEGAPDEGADQAPDEAAGRAEEPAKPPQPPAKRARAPRTRKSGETP
>NC_016582|534066:599853|590293_592558_-|WP_014173104.1|tail|DBSCAN-SWA
MAEYLSPGVYIEEIDAGPRPIAGVSTSTAGMAGVTVRGPYTGKPKLVTNFLEFQNTFGGFLPEPDALIRDTWANDPKEGGRWWLFPLAVKGFFDNGGQRLYVKRVASRQATPASGVLGHGLVSPVARDAAKGATRLELGHLIGFSGVGQQIQLFRGDDQQVIHTAGVAAYDATAHRVELDAALTAEVRTGRGDYVQIGARSAEETLEFSAVSPGSWGGAVQVRIQPMASAALPVLPDPQEGALFVTQLAADAAADSATVEVAAVAGLDPDDLPPEVWAQIGSGRFKVEVGQPADGKVTLTLPSGTAHEAWRRGLVVRRVRRGNTSAGPTLRVGGASRLYEGAVVQLDDGTTLTIRTVEAIAADLVTFDADVPGTLFETDRLRLVEAQVDARFTDPSGAVVTESYPNLRLTGDAPTNLVTTLAGRSQLVRAVALGALSTDPAKFPVPAVGSWLTLADGDDAYGSLSVADFVGEDGGSGKRTGIAALEDIDEVAVCAVPGVWSGTAESALVTHCELLRDRFAILDPQDGLDIEGVQAFREPFDTKYAALYHPWLVTRDPATGRDVEVPPSGHMAGIYARVDVERGVHKAPANAVIRGIRLTDGIAQDITKRHQDLLNPKGINALRFFPGMGHRVWGARTLSSDSSWKYINVRRLFLYLEESIDEGTQWVVFEPNDEALWALVRQTVTNFLTTVWRSGALAGTTPDEAFFVACDRTTMTEDDLANGRLICVIGVAPVFPAEFVIFRIQQKTRETQLA
>NC_016582|534066:599853|595387_596761_+|WP_086013632.1|DBSCAN-SWA
MPIVLRVLSRINCRIKFAAWRQPRAILWATAGLVTLGFLIALEIAARRYTGQPGPITNQAREVIFAPKPGPLYGGMALMMVVLTWRQRFIALGAAIGIDIVFVLVRWAVGADVPADHFFGNGALWVMLGCGVIAVTRRTGRERALLLKGVGLGLLLVAGRKTGDTWLLITAKTRPTVLDEYVATADHALGNPSWLAGRILRATEPIGTHLLDWVYGELAVAAIVVALYQLRNVAVERRFPRHHLLRTFLVIGLLGPAIYMIFPVVGPIFAYGPGTSGTGGLQWAVANLWPNTLPPIKPPHPVPYDGITPRNCMPSLHTAWALAIFIHSRKGPWFLRFAGAFWLIATLGATLGFGYHYGVDLVAGVVFALTIEAALRTFDRGWDRSGLQLVAYGTTVFAALLVLYRYLPMEMATHPWVFGPLLILAMASVIYGYVRTTKRWEPTSAPARQPEPQPELV
>NC_016582|534066:599853|558526_559825_-|WP_043485994.1|DBSCAN-SWA
MVSRQNESAAKGPEFPSRRSVLATMSALPALVAATPAVGASAAAATVIVDPSAVRQTIRGFGGMNHTVWISDLTPAQRDTAFGNGEGQLGFSVLRIPVHENRADWSREVATAKRAIEYGAAVIASPWNPPAQMVETFVHGDQSNAKRLRYDMYGAYAQHLNDFCRFMKDNGVSLYAISVQNEPDYAHDWTWWTPTEMIRFLRENAGSIEIKVIAPESFQYVKSFSDPILNDPTALANLDILGAHLYGTPYQNFPYPLFKEKGRGKELWMTEVYYPNSSDSADLWPQALDVAEHIHHALVDAEFQAYVWWYIRRSYGPMREDGRISKRGATMAHFSKFVRPGYVRIDATSNPQSNLYVLAYKGGDSKVVIIAINKGTSSVSQPFTLVNNTSSSVSSWLTDASRNLASLGAMSVSNGSFTGQLPARSVTTFVTG
>NC_016582|534066:599853|538347_539877_-|WP_014173063.1|DBSCAN-SWA
MTSTALPTTDELRARARGGLQNIGVDVAEGNDFHARTPITGESLLGLTAATDAATEEAIAAARTAFLTWRTTPAPRRGELVRRLGELLREHKSDLADLVTIEAGKIRSEALGEIQEMIDICDFAVGLSRQLYGRTIASERPGHRLAETWHPLGVVGVISAFNFPAAVWSWNTAIALVCGDTVVWKPSELTPLISLACDHLLARAAEEVGAPRDVHRLVLGDRAIGEKLVDDPRVALVSATGSTRMGREVGPRVAARFGRSLLELGGNNAAIVAPSADLDLAIQGIVFAAAGTAGQRCTTLRRLIVHRDIAGTFIERLTAAYHKLPIGNPFDDTTLVGPLISTTALDAMRGALSRVQAQGGKILAGGNRRLTEAAPSAAYTEPVLVRVDEQTDVVREETFAPILYVLTYDTLDEAIALHNDVPQGLSSSIFTRDQQEAEIFLSAAGSDCGIANVNIGTSGAEIGGAFGGEKDTGGGRESGSDAWKAYMRAATNTINYSSELALAQGVSFL
>NC_016582|534066:599853|568719_569361_+|WP_014173085.1|DBSCAN-SWA
MDESALRQLRAEASRADYASMARLAHALYENGLSVPEVMRECYGVDLPTEFLVLAEADLWRLDLLLVCTHQPWWLAVPPTRGGPVAAPDPPTGTERKLLALDPDLLPLGYTLGTNSPPWENKEVLCYRLSELAAGRPTVFRLREKSTRRDKVKRRGESLMTVLEELHLEELRETERQMRDWDVGAEEELVGAARELVERVEELRRKVAAREAR
>NC_016582|534066:599853|589817_590273_-|WP_014173103.1|tail|DBSCAN-SWA
MPPVTRDDPYASYNFQIIVTNVSDDGVAVSGSFTEVSGLELEVPPIEYRTGSEDITVRKIPGLKKFTNLTFKRGITGHVGFWNWVVEALNGKVRRTSGSIVLLDENRQETMRWNFDRGWPTKYTGPTLSATKNEIAMETLVLAVEKLEIDV
>NC_016582|534066:599853|547453_548149_-|WP_014173071.1|DBSCAN-SWA
MPHDSTPAAPSATPVRRTTLAAQVVEQIRSRLLTGTFPPGSQLGEAELAESLGVSRGPVREALARLVHEGLLLSEPHRGVFVPLLGEADVLDIYYAREALEAAAFRRVITAPRPPGLLSALDETVDELARATRTGDWSKVADLDVRFHSLVIEAAGSPRLRRMFDTVIAETRLCLNLQADADPARLDLVDEHRELARLIAGDDVAAALATLAQHFEEATVTVRNRLRAVRR
>NC_016582|534066:599853|593305_593884_-|WP_014173106.1|DBSCAN-SWA
MGDFGVIADVSTVIVETLTQALRGLSQVEPPIAELNDLSETVQTPPPKLTVFLYEIAEDPTSRNRPPVRSQPPDPPNVRKPPMALLLRYLITPWGGDPATQHRMLGRALQTFYDDAILDGVQLSGSLAASTDSLHLSLTPLTLDQKSWVWYAIQKPYRLSLNYEVRVVNLDSAVETAVRPVNSRAISGAAMP
>NC_016582|534066:599853|553868_555017_-|WP_043485990.1|DBSCAN-SWA
MKAHEHPHPPSPAHAHPKGHASAHDHGHDHDHDHDHGRSHDHDHSHSHSHGEGRWSRWKHQVTHMVKPHSHEAADKVDSAMESSAEGMRALWLSLAILGATAVFQTVVVLISGSVALLGDTIHNFADAMTALPLGVAFVLGRRVANRTFTYGYGRAEDLAGIVIVLTIAASAALAAYEAIDRLMNPRDISHLGIVSIAAVVGFIGNEWVARYRIRVGRKIGSAALVADGLHARTDGFTSLAVLLGAGGAALGWQLADPIVGLLITAAILLVLKDATREVFRRLMDSVDPTLVDKGEAAVREVPGVRDVSELRMRWIGHKLRAEATVEVDGGLSVRESHAVAVDVEHALIHAVPRLTAALVHTDPALGPDADDPHLALAHHMT
>NC_016582|534066:599853|545374_546385_-|WP_014173069.1|DBSCAN-SWA
MRALAKADRAPDLTARQPLVTVEDVVKHFPVRGGVFSGKAYVRSVDHVSFTIAPGEVLGLVGESGCGKSTLARAMLGLTPVDSGRVLFDGVHVARTRGRDRKVLRRSMQLVFQDPFAALDPRMRLGTSLDAPLAQHGLGPREERHQRILQVLDQVGLDASFLGRRPGECSGGQLQRLVVARALLLRPRLLICDEPTSALDASVRAQILNLLVELKDELDLTLLMISHDLRVVRHICDRVAVMYLGEVVEVASREELFERPAHPYTRALLTASLPEYSDGEGEFGALRGEPPSPLSPPAGCRFHPRCPRAAERCGTQAPTLTTGPTGRSVSCHYPSA
>NC_016582|534066:599853|574248_575385_-|WP_014173090.1|DBSCAN-SWA
MTGPLRPAFHEGQVLAAADLTAAVEHARGQSARHARHLHEWGIVEGLGLATEARTDPLTGVRHVEVSVAAGIALDGTGREVVVTEPAVLRESDFEEVNGADQPTDEPYPVFLTAADREPAQRPGPVSCSGSATKTRVEESYQILFGRLGDERLVEEQQPPAIGDPPADPPVRWLILLGYVRWTDGHFSGVETTARGVVVRFAGVRADTVVARSGALTLRTAPAAQEGKPALVLSGGDQPSLVFGLYQGGGAVAPLMTVAANGNLAIAGSFSGRMPAGSTLVASGTATDGMLLPLPSGVTPEQVADGRVVIHVQLTPRTPPLADTALYSPVEATVDGDRRVRCRMRLYDPLVTPAKVVEQPGAVDFLVLATVAATNGGG
>NC_016582|534066:599853|534066_535590_-|WP_014173059.1|tRNA|DBSCAN-SWA
MTAPRRYITTTIPYVNARPHLGFALELVQADTLARHHRRRGEQVRLLSGTDDNSLKNVLAAEAAGTDVQSFVDRNADAFAALRGPLALSFDDFIRTSSDPRHRVGVERLWRRCAASGDLYRREYEGLYCVGCEQFYTPDELVDGRCGEHGTEPQLVTEENWFFRLSRYAGRLHQLISSGDLRIEPVARRNEVLALVEGGLHDFSVSRSHSRARGWGIPVPEDPSQVVYVWWDALGNYVTSLGYGTDDTAYDQWWATSERRVHLVGKGVVRFHAVYWPAMLLSAGLPLPTDILVHDYLTVDGRKISKSAGTTVDPAALAAAHGTDAVRWWLLRDVPRIGDADFTPDRLTGRADADFAGGLGNLIHRIVTMVHRFRGGTVPVSAPSSGLALVDVCRKVPGLVDAALADFDFRRAIRAVWNIVEEANRCIDATRPWELARAERQGDGEAAKRLDTVLVTLVTACRVLADELRSFIPDAATRIAAQLTPVEGRLPAAQPLFPRLQEDTRLV
>NC_016582|534066:599853|539908_541300_-|WP_014173064.1|DBSCAN-SWA
MITQWQLRAAFAARLSEMYGQEVPAYTTLVDVSREVNEDVLRAQGADAERLGSISRVTAERHGAIRVGTPKELRQVARIFAALGMHPVGFYDLREAAASAVPVISTAFRPVDGEELARNPFRVFTSMLTPADPRFFDADLRSRLEAFLADRELFPAELLALADRATAERELPEADAERFLRLAVHAFELSPEPVDQAWYQTLERISAVAADIGGVRSTHINHLTPRVLDIDELYRRMTERGIEMIDTIQGPPKWQGPDVLLRQTSFRALAEPRAMRTPDGSVVSGALRVRFGEVEARGIALTRKGRALYDELLGHIDEQVSQNAADARGDIARAVWERHLPGSERELAAAGLAYFTYRLDPDRPRDGNRPPTSVSELVRQGWVSAEPVVYEDFLPRSAAGIFQSNLSGEGIRNNEREGTAYDAAWLSGAIGHDVLDPFALYEQQQNRSLAQVAHELDLTGALG
>NC_016582|534066:599853|557515_558466_-|WP_014173080.1|DBSCAN-SWA
MRREWTHHPFATSTNGLASGNSTAEAALHALYEVIERDAVARLTTLPRAERPRLDLPSVDDPDCAELLDRFGAAGVSVTAFDATWPPGEGGTGVPCYHVSVWSPDLPVVVPGSGCHGAPEVALARALTEAAQGRLTVISGSRDDLSDRLYALQADPAKGAPRLAPSLRTVPLRPRETGHDLAEESRTVAAGVTTLTGTEPVLVEPGRPAGDARVCGGPGPRLLLGPRRTARRPDAGTAARDPGLGVRPADRGPGPAAQPRAEPARLSRLPGLLRPAAHLLHGALGHRSVRQRDPVLPLARLKTVEPFALRERELQR
>NC_016582|534066:599853|592568_593309_-|WP_043486002.1|DBSCAN-SWA
MSRFMPLAGSTLYSPAWFIPFDDYARRVRSAGVAVQLDRFDDEGDGDGAWLPLDDVPVRTPSAALAYPGLGRCGEPWAARPRRHRARFAAAGYQPLYPADEQPYSADLVGVEFLVYPYDDAHPPAVVTEPRLVRLLPSVSFPYPPGLRTVHGAVVDATTRTPIANALVEARGRTSRDLTPWHERTLSDAAGAFRLALRWEGEKADEHAVEETFRLEATERPGRSGSLVVRLPQDIERRHVIEIREQ
>NC_016582|534066:599853|580626_582687_-|WP_014173093.1|plate|DBSCAN-SWA
MTGDVWWERDAREQERADGRIVPGPGPTGGGPELVDATREAVRAEVRGRIAGYTPDWTDPDRQDAGVALVRLFGTQAEPVLGRVNRLPEKALAEHLAIAGVRRRPAGAAAALLEFTVNPPNGSSVLVPAGFQSAAQTPAGQVVYETDQDLYATPATLGDLAVQEAGTLEPLPLGPSGPSRPFAPFGRDPEPGNGLWIGLAGPAGPYPRLSLGIVVVAAPPAPTASGGALPLPLPPAPLLRWDVLDGTRLVPAELIRDSTAGLSASGTVELRVPRSWEPGTPAATRPRLRWLRVRIAHGAFTGPAPVLSGLRLNVVAATAARTIRDEPLQPVQDPAATGRRRMKLSQVPILAGSVVIEVDDDAGGDVFGTSAATTAGTSSRWREVESLAGYGADDRVFTVDYDSGEVTFGDGVNGAAVPPGFRNVRAVRYRVGGGSAGAVRAGAVGAVVTALPFVTGVGNPFPASGGTDAEPDADAMRRGVGELRARGRAVAPADYGLLATRAPGASVARARGVPGLHPDFAGAPIPGVVGVLVVPPVLPDDPGEPPVPTAATLRAVADFLSREAAPAGVTVVAAPAPYHRVAVESWVTLDPDLDRAAVLARAGDAVRTYLDPLRGGEDGAGWPFGGALRHTALVRRLLAVDGVLAVTRLSLTVDGVRRPPCTDHALPPHTLVWPERPLLIPVGDPS
>NC_016582|534066:599853|550023_551301_-|WP_014173074.1|DBSCAN-SWA
MKTVPYWLDTAPPGPDRSAAEVGGRTDVAIVGAGLTGLSAALHLARKGAQVTVLEQESVGWGASGRNGGMCTTGLAIGFLTAVQRYGIPTAKAAYLAYNEAIDTVEKLVVEEEIDCDFSRTGKLNLAAKPAHYERLARTHEALADLIGYPTQLIPKKDIRSEVGSDHYHGAMADPQGAGLHVGKFVRGLAEAAAAQGVRILEKAPVTRARRVSGTAHDLTTPVGTLRADQVLVATSGYTGSPFRWLRNRIIPVGSFIIVTEPLRQEVVDELMPTRRMASDSKNILYYFRITPDNRLLFGGRARFAMSNPQSDRKSGQILRKGMLSVFPQLDGVRIDYLWGGLVDISLDQMVHSGERDGLFYSVGYSGHGVQMATHMGRQMADVMDGRPEANIWRGMKFPRVPGHFGPPWFLPFAGAYYRALDIIK
>NC_016582|534066:599853|594080_594278_+|WP_014173107.1|DBSCAN-SWA
MEIPSDRTGVLILRVWVEDGRPDGFRARIVRSGGPHQAPPTAVSAVDDVLSAVQAWLDQLLEPDR
>NC_016582|534066:599853|562265_563786_+|WP_106436512.1|DBSCAN-SWA
MARRTGADPRAVLDWLSRQIDADIALVGSAGAVETATARFPRQILPSLEPTLARLAGGQMAAAATEAGALQVRLEALGPRAPRPVLVVAGTSAPTPDAASLVSHAGSVIALLDRAQDADTTFRGYQHKARQLRFAVFSALLAGDITLARRMTTGAVPALLDAQRLRVYLLQCTPEDRDRLAQIHQDGSGYHGTGLMVHCPAFKEHLICLVAEDADGADGADGADETEVADGADADPETAHGQGTVLRRLVRENPHYALGISSPYPLGATAEAYGQALHALAAARHTPERVGAYLGRTPLVPLLPHEDAGTWARAFLRPLGSTPRATLDITRLAVTFPRSAVARLLDISRNTVSHHLRRVETTLGLDLSDVRTRAALDLAFCLSPGPQSDDSLGGSGGSGGSGGAYGRPTPTLDELLRTEPAHAWAREFLRPLQDTRGRDLHTTLCAWIDANTDAQRTARHLGLSRNTVRAHLRAAEHLLSRDLLTTGSGIHDLVHALHITGLPSAG
>NC_016582|534066:599853|573715_574246_-|WP_014173089.1|DBSCAN-SWA
MALSVVYAVDTGHVVGALALTGAGAPPDVAALVGRALPLRVSLGTGRIATLPLSARDLAVASVDDEPAALAVPLDFGVEVTSDGKPKPALVRLASWTDGIALTEDGLTVTVKVAVARPTPVLALVSDEQDTHVLAGEIPAQQTQAKLPVTLVKGSVHGVLVLATGWAGHLEKAAVT
>NC_016582|534066:599853|551306_551975_-|WP_014173075.1|DBSCAN-SWA
MIDFRPKYITFDCYGTLTAFGMSALTRELFADRVAADRMEDFLDDFEAYRIDEVLGAYQLYPDVIRHALKRACDLWDIEYRDTDGAAIVAAVPTWGPHPDVPDALRTLADSYPLVILSNAANDQIGGNVEKLGAPFHAVYTAEQARAYKPRFQAFEYMLEELGCDPGEILHVSSSLRYDLIPAHDLRIPNKVYVNRGYEPSVPYYGYHEVSALSELPALLGL
>NC_016582|534066:599853|552016_553435_-|WP_158104720.1|DBSCAN-SWA
MVDEPFAPAANWALETDDSFVLSKAGCLETLVKYQTGGGIKPMLAASWKQTRPTTWDFTLRPGVTFQDGTPLDAKAVAGALKHALAAKTPAPGFSPETIAAVTAVDGSTVRITTPAPDALLPYRLAAPNTGILAPKAYTGSSTNPEGTCTGPFRITKEIPQQAIQLKRNPKYWNGPVKLASAEVRFIADGAKRATQIQTGEAQISRKLPVPSVQDLKGNSSVEVLTEQLPRTTELVLNNKKAPFDNEKVRQAFQAAIDTKAITNAVYQGAGQQAVGPFGPGEPWTPDGAAPVKADPAKAKALLSEAGVKPESIKVSLIAYNEGSGFSDLAAIIQQELKAIGVKASIRTADYASVEPDLLSGDFDAALLSRNHLGDMPDPLGYLTADYTCKGSYNLSHYCDPKTDGLIKKAASAKDPDTRYADYAKVAAELQSRAVDVFLVHETESVAVASGLKGFAVHPYYTLTANLSLGTK
>NC_016582|534066:599853|555177_556473_-|WP_043488637.1|DBSCAN-SWA
MTRPAPDADTTGPISDTPDTPETTHTAQAQRRILRVLVASQILSGAGLAAGVTVGALLAQDMLGTSSLAGLPSGLFTAGSALAAVAVGRISQARGRRPGLATGYLTGAIGSAGVITAAVLDTSVLLFIALFVYGAGTATNLQARYAGADLAQPNHRARAVSTVLVATTLGGVAGPNLAAPTGDLAETLGIPHLAGPFMLGGAAYALAALVLAIWLRPDPLLTARTLAAAEQSSNSATDTSPATDAAHERRGGVVLGALVMILTQLVMVAIMTMTPVHMHDHGHGTAASGLVIAIHIGAMYLPSPITGRLVDRYGPPKIAAASGLTLLAAGILAATAPGDSVALLALALALLGLGWNFGLVSGTAIITDTVPLATRAKTQGTVDVSIAIAGATGGLSSGIVVATASYPILALTGGVLALAILPAIAATASSR
>NC_016582|534066:599853|536083_537532_+|WP_078610280.1|DBSCAN-SWA
MHDSSVGSVGTSTGVPGSEQHTSWNRRLVGQVAILILVNAMVDTVVTAPLLVLPEMLDHFGTDQSAWIDASSLLAGAMWAPLLGKSADIHGKRRVLVMTLLTALAGALVCLVAPSLWVFIFGRLLQGAAVGAVFLTVALIRDMCAPDLAMIATGIVTSGSALLSIGMPALFEITAAKFGWRSVFVASAIFAATAAVLVRRLLPKDTLRTPGKVDIAGALLLGGGLAAVLSYISLGSDFGWFAVGPLALLVAGAAALARWFLVASRVPEPVIDIRNLGRPLELTLLVVVFGTGAYQSMLTLFGLIAKVSADQQLGYGLAAPGALGLLYGVPAIGIVLGGTLAGALGTRFGPAVTLAGGVALGTVGTVGMFLGDSRLPLAVVCSFLLSLTAGTLVTSGFNMAATLAPPERQGVVSSMVMVMVATGAVILKFVGSAVLKSTNTVIDGETVNSAAGVHDYIAMAAGAFTAAAVVAVILLRTRRGAR
>NC_016582|534066:599853|543476_543836_+|WP_014173067.1|DBSCAN-SWA
MPVNDEQATPTRSHTHPSGAAQFSTAAHVFALLSDPTRLHLVWSLARGEADVNTLTEASGAARPAVSQHLAKLRLAGLVQVRKEGRRSVYSLHDGHLRRLVIEAVNHADHMVTGAPPHD
>NC_016582|534066:599853|585061_585763_-|WP_014173097.1|DBSCAN-SWA
MTMRGTPRARSTDKRYYGVVEALVVENEGDDEGQVKLKFPWFDDTTVTDWVRVSQLYAGGGYGSVFVPEKGDEVLVAFVHGDMRYPIVLGGLYNGEDKPPTARTEGRDQKLIRTRHGHEVLLDDTQSKAAVKITSAAGHVVELDDQGKAIRITAAEGGSVTVTAQGEITLKAPKVTLDSPSIDLGGGATEPLVLGNALLQAFNAHTHPSAAGPTGPPTPPLTPAVLAKKARTA
>NC_016582|534066:599853|577399_578626_-|WP_043486000.1|DBSCAN-SWA
MTETETSRTEEFDAPPLRRLRYFHGQMLGARDFQREQEYHREKLRLRMRCLLGYGVVCGLHVEPAPRDEDDCPPDAEAPAEGEADRTEHTRRRAKVKLTPGLAVDCDGNEVVVRGGCVIDLWKALPPDERDTDTVWVGIEYAERPVEPTRAVYNDACADTSDCEFGWTEECHKVRVTGCEPPVDERCDTCCSPCEHKVLWLARIDCVDWYEPVRRDQIHMNVRRPFGRHLPTVITGINWIHGHTYTIDEAKALLGTQDQDGGLVVRFSADVRSDTLRPGVVELQVIEGGSGRNASTWYMGGAFAEPDAESDGCDEFTEGFRYRQTTRETLQDGDRLLITVRAAFILDRCCRPVDGTHVGGRVPTIDAEATPAAAHGGCHLPPSGIGPWTSGTGAGGDVFESWFFVKER
>NC_016582|534066:599853|569736_571851_-|WP_014173087.1|DBSCAN-SWA
MGEPAVEHLRIRLADLHQALRAAVERQARLAARLTRPDLTPYCVTDEQVDVLLGEVHAFTDTMAEPYEPRPTEPEAERDLRRRASAEGTTLPLDALATRFGLTRAEQDALLMAAAVELDRGYERIYAYIVDNLNRRLPSVELLVSVGAHGSAARLALRRALGPAGPLRRYGLLRAHGEAAVGLAQELVLGPGVLDFLLGWGSDVGLLGHDPGEVAPPEPRVLSPYLSSDRLIRLGRALGSGDIDLAGLWGCPPDGQLDAVQALARAAGAPLRTLTADPEADPQADLRTAAALGAVLWIPTDDLHGEPQRHRAAALSAALPRSRVPVCLTGLKPWRPAGLLASRAYAELTVPVPGFTDRRAMWSAALPDLDTTLLEDLAVRYRMSGGELRAVARVADAGARLAGNGHPQPVADHVEPAIATVTRGRSGSAVHSILPRRTADDLVLPKVQFRQILEIASAFRAWPRIAESWGFARRAGHGGVKALFTGEPGTGKTMSAEIVAGMLGLELLKVDLAQVVSKWVGETEKNMETAFRQAEESHAVLLFDEADALFGKRGEVKHGTDRYANLEVGYLLQRLETSDGLVILTSNLKDNIDPAFTRRFHFVVHFPRPAAAERRRLWRLAFPEQAPLASDVDLDALARLDMTGAAITSAARTAALAAADGDSATIGMRHIVRGVARQFQREARLLRPTELGSHAQLLDDGTPG
>NC_016582|534066:599853|564099_568719_+|WP_043485996.1|DBSCAN-SWA
MPPPKALALRPRTAKTAPVPTQDRPEVRSPAGPHFPPSNAAVTAALAGGHGAAPLPPLSALSAPLPPVGQDTVGNGAIAAARSAPVNTPEAEPAPAAAASGAAPDVQARPGPSADPKFATLKKDVQRKKRSVASSHPPPKAEAGAAQDAARPPKDDEEAQGKTANAEKMNEAQPKDFDKDAFIKAVEKAIAEKAPKNLDEADKFADSGKADEVRAEVHGKVGEGKADSAEQISTTTAAPPDTSAAVPKKVVPMTPDRPPGTPGTPNPGNAVPDKLPPSATDLSAGPAQVDRQMTDAQVTETQLKKSNEPTFKNALGEKKAAEQHSAVAPGRMRGHEKKELRAATAQAQRLGAAAMGAIGAQRVRTGQQVGAGKTGAKGRDEEKRAQVTAVLQGVFDTMKKEVEAILDGLDKLVDDQFGREEKAARDAFTAEHKRKMEEYKDRRYSGWTGKARWVKDLFAGLPAEADKIFEAARDNYVRRMRQVISDVADTIGSELNRAKRRIAQGRTELQAAVRKLPADLRSIGQQAAAEFSDKFDELTQSVDDKGTQLVDTLATKYTDALKSVDDEIAAEKEKNKGLVAKAVDAVKSVINTILELKRLLLSVLAKAASAVMLILKDPIGFLRNLVSAVGAGLKQFLANIGRHLQQGIMSWLLGKTAEAGIELPSKFDAQGVLRMLASLLGLTWQNIRARIVRKVPKMEPAVAAAETAVPLVAEVRKRGVAGMWDDLKTRVGDLKKDLLDKVIAYVTPTIVVAGIMWVISLLNPASAFVRAVKLIIDIVRFIVTQARQIIEFVGAVLDAVIAIARGGSGGVPGMIERALARSIPVLLGVLAAILGVGGIAARVKQIVQAMSKPVDRAVDWVIDKIVGLVKKLWSKIKSAFDRKKPKPKPKPKRRPDRKRPGRPRRRRRPDQRRRPDRRRPKRKRDPKKKRPDKRSKKDMLRALDAAVRDATRLLNAKSATEETIRRGLPAIKARHRLSSIELEKSARNTYFITVSINPKKKTPFKTLFPYKIGKAAASTGLTDAGVSVGALHDIGNPMREKYAAAFVINMVATPNEVKAKPRIAARYLEEAWTGSPEKKVAWARTAVIIGVNSAERLDPKRSKSGVPAISQALGAILRPDKLRMIAFGFVWTPEWFDINSKKTVPFSTVKNTYDGLDDTHKKAARDEEGKGIGSKRAKAVPYGLLRGHVFTSTHTKRAVTVLSKVNQQVQVLSQDPDGGVRAPKGRGVLAAYDQILRTITGDPVMIVGGYDFDELKWEEGAQERVVQLTQLANAIDRAVRAAVARHIPEMTYPTEPNTLVKVWDKNRRNGVFQMMQNRADEAAKDALPFGFGEGEGRSFRKWLLRLYGNAFSIVHDQSASVSSDAKLNDPGRKLAVRGPGARSKRHVAYAIMLQSQSMANAQVLANELFLANQGLGLPAKNFVQMTVFSHVEAVVKMMVDNPDLKVGDPKIQKAIDAMEKSVREYLGEKIPPKADRKSGDQRLHDILVRAEAMTREIITALTAEELKSVWRKLSLLLKEAQAEAKKNAEAAKHKKAGKR
>NC_016582|534066:599853|537578_538280_+|WP_158104737.1|DBSCAN-SWA
MDDILREIADLREVMTNRFRQVEALTNLYAIIPVKHAMPQPTKWTASPDLLLFLISHIQERRPVSILDIGSGATTVWMANALRHFEIPGKIISIDHDKSFGAVTAATLTQQGLDTYADVRIAPLVEVDIKGERRHWYDPTQLEDVENCDMAVIDGPPGFTHPLSRYPALPMLESKLSSDARIFLDDASRPDEREIVERWCREYPDWSSDFIDHEKGTAVLARRTVIADEYPAE
>NC_016582|534066:599853|587807_588326_-|WP_014173101.1|tail|DBSCAN-SWA
MTLDPLPKYRFLVTLDPGDAYLPPAQALLLPLAASGAFQEVTGLGAQLEVVSYPEGGRNDSVHQLPLRHSWNRITLKRGVVRDPGLWAWYQAGLADSLGARRDGAVIVLGPDGVPGAAWAFHGGLAAKWSGPDLHAEQNAIAIESLEIAHEGLTKVLQDAAANALPRLSQGR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014173059.1|534066_535590_-|tRNA	methionine--tRNA ligase	A0A1V0SEZ7	Hokovirus	7.6e-58	28.9
WP_078610280.1|536083_537532_+	MFS transporter	NA	NA	NA	NA
WP_158104737.1|537578_538280_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_014173063.1|538347_539877_-	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_014173064.1|539908_541300_-	VOC family protein	NA	NA	NA	NA
WP_014173065.1|541328_542501_-	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_014173066.1|542637_543318_+	hypothetical protein	NA	NA	NA	NA
WP_014173067.1|543476_543836_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014173068.1|543866_545345_-	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_014173069.1|545374_546385_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.5e-14	28.6
WP_014173070.1|546381_547440_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.5e-15	31.2
WP_014173071.1|547453_548149_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_014173072.1|548138_549044_-	ABC transporter permease	NA	NA	NA	NA
WP_014173073.1|549030_549978_-	ABC transporter permease	NA	NA	NA	NA
WP_014173074.1|550023_551301_-	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_014173075.1|551306_551975_-	haloacid dehalogenase type II	NA	NA	NA	NA
WP_158104720.1|552016_553435_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_043485990.1|553868_555017_-	cation transporter	NA	NA	NA	NA
WP_043488637.1|555177_556473_-	MFS transporter	NA	NA	NA	NA
WP_014173079.1|556714_557392_-	metalloregulator ArsR/SmtB family transcription factor	NA	NA	NA	NA
WP_014173080.1|557515_558466_-	YcaO-like family protein	NA	NA	NA	NA
WP_043485994.1|558526_559825_-	glucuronoxylanase	NA	NA	NA	NA
WP_086013631.1|560212_562027_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.5e-33	26.4
WP_106436512.1|562265_563786_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_043485996.1|564099_568719_+	hypothetical protein	NA	NA	NA	NA
WP_014173085.1|568719_569361_+	hypothetical protein	NA	NA	NA	NA
WP_043488642.1|569437_569731_-	hypothetical protein	NA	NA	NA	NA
WP_014173087.1|569736_571851_-	ATP-binding protein	A0A125SJ49	Acidianus_tailed_spindle_virus	2.9e-15	40.0
WP_014173088.1|571856_573719_-	hypothetical protein	NA	NA	NA	NA
WP_014173089.1|573715_574246_-	hypothetical protein	NA	NA	NA	NA
WP_014173090.1|574248_575385_-	hypothetical protein	NA	NA	NA	NA
WP_014173091.1|575381_577397_-	hypothetical protein	NA	NA	NA	NA
WP_043486000.1|577399_578626_-	hypothetical protein	NA	NA	NA	NA
WP_014173093.1|580626_582687_-|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_014173096.1|584642_585065_-	GPW/gp25 family protein	NA	NA	NA	NA
WP_014173097.1|585061_585763_-	type IV secretion protein Rhs	NA	NA	NA	NA
WP_014173098.1|585759_586941_-	phage late control D family protein	NA	NA	NA	NA
WP_014173099.1|586951_587623_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_179285154.1|587619_587802_-	hypothetical protein	NA	NA	NA	NA
WP_014173101.1|587807_588326_-|tail	phage tail protein	T2KT02	uncultured_phage	1.1e-08	37.0
WP_014173102.1|588322_589816_-|tail	phage tail sheath family protein	A0A2I7SAT7	Vibrio_phage	5.6e-05	26.8
WP_014173103.1|589817_590273_-|tail	phage tail protein	NA	NA	NA	NA
WP_014173104.1|590293_592558_-|tail	phage tail sheath subtilisin-like domain-containing protein	J9PVC2	Bacillus_phage	8.1e-48	32.5
WP_043486002.1|592568_593309_-	hypothetical protein	NA	NA	NA	NA
WP_014173106.1|593305_593884_-	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_014173107.1|594080_594278_+	hypothetical protein	NA	NA	NA	NA
WP_055413837.1|594432_595323_+	transcriptional regulator	NA	NA	NA	NA
WP_086013632.1|595387_596761_+	inositol phosphorylceramide synthase	NA	NA	NA	NA
WP_014173110.1|596937_599853_-|bacteriocin	NHLP bacteriocin export ABC transporter permease/ATPase subunit	W8CYL7	Bacillus_phage	6.2e-24	23.3

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NC_016582|1637303:1727625|DBSCAN-SWA
GTCACGCTGCATGCCGGTATTCGTGGAGGATACCGCCGAGGCGATCGTGCCGGCGTATGTCGAGGCGGGCTAACGTGTCCGGGTCGTGGATCGGTGGGGGTAAGGGGTGCAGCGGTCTGGCGTTCGCGATGCCTTGGTGTGGTCGGTGTTCGTTGTAGAACTGCTCGAACTCGCGTAGGGCGTGGAGGAGGTGTTGCTGGTTCCAGATCAGCGTCCGGTCCAGGAGTTCGCGGCGACAGGTCTGTATCCACCTTTCCGTGATCGAGTTCATCCTCGGCATCTGGATGCCGCTGAGGACGACGTCGATCCCTGCGTCCTTGAGTACGGCATCGAACAGTTCGGGGAACTTCCCGTCCCGGTCTCGGATCATGAACTGTGCCCGGCAGCCGAGGTCTTCGAGGTCCATGACCAGGTTCTTCGCCGCTTGGGCTACCCAGGATGCGATCGGATGCGTGGTGGCGCCCAGGATCCGGATCCGGCGACTGTCGTGTTCGATCACCACGAGCACGTACATCCGCATCCCCGACAGGGTGACTGTTTCCATGAAGTCGCAGGCCAGCAGGGCATCAGCCTGGGAGCGAAGGAAGGTGGCCCAGGTACTGGAGTTCCGCTCGGGTGCCGGATCGATGCCGGCCTCCTTCAAGATCTCCCAGACAGTGGACGCGCCCACCTTCACCCCCAGCACAAGCAGCTCGCCGTGCACGCGTCGGTACCCCCAGCTCGGGTTCTCCTTCGCCAAGCGCAGCACCAGGATGCGGATCGAGCGCACCGTGCGGGGCCGTCCCGGGCGTTTGGGTCGGCAGGAGGCGGCATGGCGGCGTTTGACGAGGTTGCGGTGCCAACGCAGTACCGTGTCGGGGCGGACGAGTAGCCGTAACTGTCGCAGGACGTGCAGTGGCAGCCGGTGCAGCAGCGCTGCCAGGAATGCCCGGTCGCTGGGCGTGAACCGGATCTTTTCCTTGCCGAGTTGGCGTTCCAGCACGGTGATCTGGTGGCGTAGGGCGAGGATCTCCGCGTCCTTGTCCCGGTCGGTCATTGGCAGCAGGCGAAGCATTGCGAACGTGTTCGTCACACCCAGGTAAGCCAGTCGCAGCAGCACGATCGATCATCATGACGCCCTGATAGCAGCTGCGCGAGAGCGCCAGTTCGAGCTACCGCGGCCAAGATTCCGGGAAACCCGAAGAACCTCCCCCCACCAGGGCGGATGAGGTTTCCGGCAAGGGCAGCGTTGAACCATGGCAGGATCGACACCGACGCCGCGCGTAACCTGCTGGTTTCCCTGCCGATGCCGCGCTTTGACGGGCGGATCGTGCTCGCCGTGGACGTCTCCCCGTGGCTGCGCTCGGACGCGGCCTGCTCGCCTGAGCGACTGCTCTGTCACGTCCACGGCCGTTCTCGGGAGGCCGCGCAGATCATCCCGGGTTGGCCGTACTCCTTCATCGCCGCGCTGACACCGGACCGTACTTCGTGGACGCAGATCCTGGACGTGGTCCGGCTCGGGCCCGCCGACGATGCCGCGGCCGTCACCGCCGACCAGCTTCGGGCTGTGGTCGAGAGGCTGATCGCGGCCGGTCAATGGCAGCCGCGAGGCCATGTCGATCGGGGTGCCGCCCGCGACGAACCTGATTGTGGGACATCCGGTCATGGCGTCGAAGATCCGGCCGATGCCGTCGGACAGCTTGCTCGCGCTGTCGCTGTACAGCTCCTCGGCGCCGTCCGTGAGGTACAGTCTCGCCGCCCCCGGGCCGTCCCGTTGAACCTCACTGTCCACCCCTCTCCGTAGCTCGCATCCGATGCGAGAAAATCGCATCGAATGCGAGGCGGCAGCGAAACCGCAGTCGTCCATCCGGACGAGTGACAGCGGCCGACTATCGGGTCTCGCCAGCCGCTACCGTCGCGCGACGCAACGTTCCGGACATCCCTGTTCAGCGAGGTGTTGTCCGCCCTCGCCGGTGCCGACACAGCAACTGTCGCCAGTTCGCATCCGATGCAATTGGCGGCGCCCGTGCCGTTTGCGCTGGGCCGACCACCGGTGTCTCATCAGGTGGCCAGTGCTGCCTGGGTGAAGCGCGCTATTCCTCGGCTGGGGTTGGGGCTTGGGGGAGACGTAGTTGGAAGCATGCTCCGAGGGTCCGGGGGGTGAGGGTGAGGGTGCCTCGGTGGCGGTGGGCCAGGTCACGGGCGATGGCGAGGCCCAGGCCGGTGCCGCCGTGGTCGCGGGAGCGGGCGTCGTCGAGCCGGACGAAGCGTTCGAAGATGCGCTCGGCGTCTTCAGTGGGCACGCCTGGTCCGTCGTCGTGCACCGTGAGGTCGACCCAGCCGTCCTGGTTCCGGACGGTGATCTGGATGCGGTGTGCGGCGTGGCGGGCGGCGTTGTCGATGAGGTTGCGCAGTAGTCGTTCGCATTCGTCGGGGTTTCCGTGCGCGGGGGCGGGGGCGGTGCTGTCGCAGGTGAGTGTCAACCCTCCTTCGGTGAGGGGGTATTGCTCGGTCAGCCGGGAGGCGAGGGCTGCCAGGTCGACGGTGTCGCGGCCGGCCATGGGGGTGCGGGTGTCGAGGCGGGCGAGGAGCAGCAGGTCCTCGGCGAGGGCGTGGAGGCGGCGAGTCTGTCGTGAGGCGGTGGTGACCGCGGCGGGCCAGTCGGTACGTTCCGGGTAGGCGAGCGCGACTTCCAGGCTGGCCAGCAGTGTGGTGAGGGGGCTGCGCAGTTCGTGGGCGGCGTCCGCGACGAAGCGGCGTTGCTGGGCGGCGGCGTTGTCGAGGCGTTGGAGGGTGGTGTTGATGGTGGTGGCCAGGGCGGTGATCTCGTGTCCCGTGGCGGGGACGGTGACGCGTTCGCGGGGGTCGCTCGCGGTGACCGAGGCGGTGAGGACGCGGATGGCTTCGACCGGCCGCAGCGCGATGCGGACGGCGAAGTAGGCGACGGCGGCGATCAGTACGAGGCTGACGAGCCCGGCTCGCAGCAGCAGGCGGTCGGTGGCCTCGGTGATTGTTTCGGCGATGTCCTCGGCTGCGTGCGGCAGCACCACCACATAGACCCGCAGTTGGGCGTCGGCGGCGACACCCAGAGCGGCGACTCTGTCGCTGCTCAGTTCATCGGCCCTGACATCGTGGTACATGACCAGGTAGGTCCCACCGTCCTTGCCGAACCGGTCCCCGGGCTCGGAGTCGGGGCGCGCCGGCATGCGCGTGGGAATGGTCGTATAGCCCCAGCCTGACGACTCGTCATCTGGTGGGGCGGGCAACTCGGCCTTGGGCGGGGCGGGCAGCACATGGCGGGTGCCGGGATCGAACTCCTCCATGCCTCCTCCGTAGGCGACAGCACCGCGGCGGTCGGTCGCGACGACCTCGTACGGCACAGTGCTTCGGCGAACAGGAACCACACCCTCCTCCACCTGATCGACGAGAGCCCGGAATTGTGCCTGCGCCTGCCCTTCGGCGATCTGCGTGCTCTCGCGGTAGACGTCGTGGTGTACCCACCAGCCGATGCCGACCAGGATGACGGCGGCGGCCGAGGCGGCGGCCAGGGCCGTGCGGGCTCGTACCGAACGCGGCCACCAGCGGCGTCGCGGCCCGGTCGCGTTCACGGTCGGCCACCAGCGGCGTCGCGGCTCAGTCGCGTTCACGGTCATCCACCAGCCGGTAGCCGGTACCCCGCACGGTCTGCAGGGACTGCCGGTGGAACGCGGCGTCCACCTTCTTGCGTAGCGCGCTGACGCGTGCCTCCACCAGGTTGGGATCCCAGGCTTCGTCGGGCCACGCGTGATAGAGCAGATCCGTTTTGGAGACCGCCTGGCCCGCCCGGCGGGCCAGCAGCTCCAGCACGGCGAACTCCCTGGGCGTGAGCTCCACCCGGGCCCCGGCCCGGCGGCAGACCCGGCCGGCGACATCCAACGAGAGGTCGCCCACGGCAAGGACGGGCGGGGCGACCGTGGCGGCTCGTCTGACCAGGGCCCGCAGCCGTGCGACGAGCACCACGTAGGAGAAGGGCTTGGCCAGGTAGTCATCAGCCCCCGTGTCCAGGGCCTCCGCCTGATCCCACTCCCCGTCCTTGGCGGTGAGTACCAGGATGGGGGTCGCGTTGTTCTCCCGGCGCAACTGGGCGCAGACCTTGTAGCCGTTGAGTCCGGGCAGCATCAAGTCCAGTACGATAAGCACGTATTCGCCGGTTCGGGCCATCCACAGTCCCTGTCGGCCGTCATGGGCGAGGTCGACGCTGTAGCCCTCGGCGGTCAGACCGGTGTGCAGGGTGTGGGCAAGGTCCACCTCGTCTTCGACCACCAGGATGCGCATGCGGTGCAGCCTCGCACAGCGCCGGCCCGCCTTCCTGATCGGCCGGTCAGGTTGGGTCAGCAACCGGTCAACGAGGTCCCGGCATGCTGGCCGAGTCTCTTCGCCACTACTGAAAGGCCCTGCCACCGATGTCCGTTGCTGAACGTGCCCCCGCCGCGGCCAGGACGGTTTCCCCTCCCGCACGCGCCCGTCGTCAGTCACCGCTCCGGCCTGTGACCGATGGCGGTCCCCAGCCTCGGGCGCGTCTGCGGTGACGCGGGGGTGCTGAGCCGAGTTGGTCAAGCTCAAGGGCACGACGGGCCATCATCACGCCACAAGCGATGGGGAGGTCCGAGCGGGCGAGCGAAAGCGAACCCTTGCCCTTACGAGCCGACATGAGGAACACCGCGTCGATGGCGAAGCGGTCGGCGGCAGATTTACGCCTGACCAGCAGAAACCCAGTGATTACACCCGGAAGACAACAAGTTCTCAGATAGCCTCCAGGGGGAGACTTGCGCAGACAAGTGAAAAGAGCGTGCGCGGCCACGATCGCCACGGCGGCAGCCGTGGCCCTGGCGGCGGGCATGACCAGCCCGGCGTCGGCGGAGCCCGAGCGTACGGCCGGTGACCAGGCCGTACAGACCACGCCCAAGCACCGCGTCACCCTGATCACCGGCGACCGTGTCGTCGTCGACGCCAAGGGCCGCGTCATCGGCCTGGAGCGGGCCAAGGGCCGCGAGGGGATACCCGTCCAGATCCGCAAGGCCGACGGGCACACCCTCGTCGTGCCGGCCGACGCGGCACGGCTGATAGCCGACGGCAGACTCGACCAGCGGCTCTTCGACGTCACCGAGCTCAACAAGTCGGCCAACCGCAAGGCCCAGAAGCAGGGCCTCAAGCTGATCGTCGGCTACAGCGGCACGGCCGCCGCGGCGAAGGCGGACGTCCGGGAGGCCGGCGACACCAAGGTCCGCAGGACCCTGAAGTCGCTGAACGCGGACGCGGTGCTGACGCCCAAGGGCGACGCGCCCGACCTGTGGGCCGCGGTCACCGACACGCCGTCCGGCGGCGCGAAGACCGCCTCCGGCATCGCCCACGTGTGGCTCGACGGGGTCCGCAAGGCCAGCCTCGACAAGTCCGTTCCGCAGATCGGCGCCGACAAGGCGTGGGCCGCCGGGTACAACGGCAAGGGCGTCAAGATCGCCGTCCTCGACACCGGTGTCGACGCGACCCACCCGGACCTCAAGGAGCAGGTGGTCGGGGAGAAGAACTTCTCCACGTCCCCCGACGCGACCGACAAGTACGGCCACGGCACGCACGTCGCGTCCATCGCGGCCGGTACGGGAGCCAAGTCGGCGGGCAAGTACAAGGGCGTCGCACCGGGCGCCAAGCTGCTCAACGGCAAGGTGCTCGGCGACGACGGCTCCGGCGACGACTCCGGCATCCTCGCCGGCATGGAGTGGGCGGTCGAGCAGGGCGCCGACGTCGTGAACCTCAGCCTCGGCGGCGGGGACACCCCCGACATCGACCCGCTTGAGGCCCAGGTCAACAAGCTGTCCAAGGAGAAGGGCGTCCTCTTCGCCATCGCCGCGGGCAACGACGGCGACTTCGGCGAGCAGACGATCGGCTCCCCGGGCAGCGCGGAGGCCGCGCTCACCGTGGGCGCCGTCGACGACACCGACAAGCTGGCCTCGTTCTCCAGCACGGGCCCCGGCCTCGACGGGCAGATCAAGCCCGACGTGACCGCACCCGGCGTGGACACCACGGCCGCCTCGGCCCCGGGCAGCGTCATAGCCCAGGAGGTCGGCGAGAAGCCGCCCGGCTACGTGAGCATCTCGGGTACGTCGATGGCCACCCCGCATGTCGCGGGCGCCGCGGCGATCCTGAAGCAGCAGCACCCCGACTGGACGTACACCCAGCTCAAGGGTGCGCTGACCGGCTCCGCGAAGGGCGGCAAGTACACGCCGTTCCAGCAGGGTTCGGGCCGGATCCAGGTCGACAAGGCCATCAAGCAGACCGTGGTCGCCGACCCGACGTCGGTGAGCTTCGGCCTCCAGCAGTGGCCGCACACCGACGACAAGCCGGTCACCGACAAGGTCACGTACAAGAACCTCGGGAAGACCGATGTCACGCTGACCCTCGCGGTGACGGCCACCGACCCGAAGGGGCAGGCCGCACCGGCCGGCTTCTTCACGCTCGGCACCAAGACGCTGACCGTCCCGGCGGGCGGCTCGGCCTCCGCCGACCTCACGGTCAACACGAAGCAGGGCGGCACGCTCGACGGCGCCTACTCCGCGTACGTGACCGCCACCGGCGGCGGCCAGAGCGTACGCACGGCGGCGACGGTGCAGCGCGAGGTGGAGTCGTACGACGTCACGCTCAAGTTCATCGACCGTGACGGCAACCCGGCGAAGTACTACAACGCCGAACTGGACGGTGTCACCGGGCTCGCACAGGGCAAGTGGTACTCGCCCTACGACGAGTCCGGCACCGTCAAGGTCCGCTTTCCCAAGGGCGGTTACATCTTCAACTCGGCCGTCCACGTCGACCCGGATGACCCCGCCAAGGGCTTCGACTGGGTGACGCAGCCGAAGCTGAGCATCACCAAGAAGGCCACGATCACGGTGGACGCGCGGACCGCGAAGCCGGTGGACATCACCGTGCCCGACGCGGCGGCGAAGTCGGAGGTCGCTACGCCGTTGTACACCGTCGGCGTGCCGGACGGCAGCAACTCGTACGGCTGGTGGCTGGACTCGTACGCCAACTTCCGTACCGCGCACGCCGGCCCGCAGATCACCGACGGCAGCCTGTACCAGCAGTGGGGCGGTCACTGGGTCAAGCCCGCCGAGGAGTACGACACCCTCGCCGGCGGCAAGGTCAAGCAGCTCGCCACCGGTTACACCAAGCGCTACAAGGCGAGTGAACTGGCCACGGTGAAGACCGGTCTGGGCGCCTCGTCGAGCGGTAAGAAGGGCGTGATCTACGCCTGGGGCGAGCTGCCCGGCAGTACAAGCACCTTTGCACCCGGGGTCCAGCAGAAGCTGCCCGGCACGCGCACGCTGCGCCTGTCCACCGCGGGCGGGGCGAAGTGGAAACTCGACTTCGAGCAGCACGGCGGGGTCGACGAGTCCGGCTTCCCGATCGTCGATGCCTTCTACACGCTCGGCACCCCGCAGACCCTGAAGGCGGGCAAGAGCTACGGGAAGACCTTCAACACGGCGGTCTTCGGCCCGCGTGTCGGCTCAAGTCTCGGTATCTACCGCGAGGGCAACGGCATTTACGGCTACCTGCCGGTGTTCACCGACGGCAAGACCCACTCCGGTTCCTCGCTCTACTCGTCGGTCACTACGACCCTCTATCGCAACGGCGCCAAGGTCGGCTCGAACAGCGACCCACTGGAAGGGGCGGGCATCTTCACGGTTCCGGCCGGTGACGCCGCGTACAAACTGACCACCTCGGTCAAGCGCAGCGTCAAGGTCGCCGCGGCCTCCACCCGCGTCGACGCCAGCTGGACCTTCCGCTCCAAGAAGGCCGACCTGGCCAAGCTGCCCGCGTCCTCGATCCGCTTCGACGCGGCCGTCGGCCTGGACAGCAGGGCTCCGGCCGACAAGAAGGTCTCCGTCCCGGTGACCGTCCAGGGCTCGGCAGCGGGCTCGAACCTGAAGTCCCTGTCGGTGTACGTGTCGTACGACTACGGCCAGACCTGGAAGAAGGTCACCGTCAAGAACGGCAAGATTGCGGTCACGAACCCGGCCAAGGGCAAGGGGATCTCGTTCCACGCCAAGATCGCCGACAAGAAGGGCAACAAGTCGACGATCTCGCTTTACAACGCGTACTACGGGAAGTGACCTGATCCGGTGGATCACCGACAGGTTCGCTGAACGCACTCATACACGGACGGGCCCCCGGAAGCAGAGCTTCCGGCGGGCCGTCCGTGTATGAGTGCGTTGCGGCAAAGGGAGTCTCTGTTCGATGAGCAGGGGCCTCTTCGTGTGCGGGGCGTGATCGCGACGGGGTAGGGGCCAGGGTCCCTTGCATGATCGCTTTCTGTCCGGGTTCATCCGGTGAGGCCGAGGGCGGTCAGGGGTCTGCGGCAGTCGCGGGCGGTGTGGCGCAGGGCGGCGGCGATGTTGGTGTGGTCGCCCTGGCGGTGGACGCCGATGGCGAGGTTGCGCAGGCTGGCCATGGTACGCGGGAGACGGCCGATATGGATCTTGGAGTCGTCCTCGCGGAACGTTCGGTCGCGGACGTGGTGCAGAAGATTTTCGATCTTCCAATGTCCTCTGATCCAGGCGGCGAGCTGGCGCCGGTCGCCACGCCGGGCGGCAGGCTGGTGATCAGGTAGACCCGTTCGATGGTGAGCTTGCCGGTGGTGAAGTCCTTTCTCCAGCGGACGACTTGGAGGGCCTGGCGGGCGTCGGGGTAGTCGAGGTGGGCGAAGGCGGTGGTCTTCAGACGCCGGATCTCCGTGCGGTGGTGGGCACGGGTGCGCTCGTGGTGGTCGAGCGTGATCTCCCGCCAGGGCAGGTGGCGGACGCGGTCGAACAGGCCGGGGTGGTTGGCCTTGACATGGGCGATGTAGTGGGCGCCGCGTTCACGGAGGTAGGCGCCGTGGGCGTGCTGGGTGTGCAGGGCGTCGGCGGTGATGACCGTGTCGGTCAGGTCGATGGTGTCCAGCAGGGGCTTGAAGGCGGGGATCTCGTTGCTCTTGTCGGCGACCTGCCGCTGGGCGAGGACGTGGCCGGTGTGGTCCATCGCGGCGAGCAGTGTGACGTGCGGGGTCGTGGCGGTGCGCGAGCCGCGCAGGGCCTTGCCGTCGACGGCGATCGCCCGCAGTCCGGCGGGCGAGGGAGTGGCGCGGGCGGTGAGGAAGGCTCCAATCGCTTGGTCCAGGGCGTCGCCGTCGAGCTGGACGAGAAGACGGCGCACGGTGTGGGGGTGCGGAACGGACACCGTGCCGGTCAGCGGGTCGACGGGGAAGCCGAGGGCCCGGCAGGCCCAGGATGGGGCGTCCGTGATCCATTCCGTGATCGCGGTGAGTGAGCGGGCGCCGGCCAGGACGCTCGCCGCAGCGGCGGCCACCAGCGCGGTCAGCCGATAGCGACGGCCCCGGACGCCGCGTGGGTCGGGGACCAGGTCCAGGAAGCCGGACAGGCAGACCGCGTCCGTCAGTGGGGCCGGCGCGGAAGTCTGGGCCAGTTGGCCCAGCGCGGTGAGCATGGGGGAAGATGCAGGAGCAGGCACGGACTCGCCAAGTGTTCATGGGACTTCGACACTCACATGATCACCGAGACCGTGCCTGCACTGCGTTCGACCCCTGCCCGAACCGGGACGTCCACCCCGACTCCGGACCAGCCCGGTCTTCCGGACAGATGGCGATCATGCAACAGCCCCTGCTCCATGGCTCCGGCACTGAAAGTGATCCAGAACCACGATTCACGCGTCGCCGACGCGCAGCGGCCGAGCGCCGCCGGACTTGCCGAGAGGATCACCCCATGGCCAGCGCTACCCGACTCGAAGCCACCGCAGCAGCCGTGACCGTAATGTCTTTGGGCTCGTCCATGACGACTGGCATGTGTGCCCCGCTCATGGGGTGTGTATCGGTGTCCAAGGCGCGCAATGCCAACTTGGTTGTCAGTCTCCGAGGTTTTCTGGCGGCACGGCGGCTGTCACTGCGGCGGGCAGCCGATCATTCATGATCTGCTCGCGTGGCAGCGACAGACCGAAGTACTGCTGCAAGGCGGCCAAGGTCGCCCGCAGCGAGTCGAAGTCTGCACTGCCGTGGAGGACGTATCCAGCTTTAACTGGATCTCCGAGGCGAACGTGGCTTCACCCACTAGGATTGTCTCGCCGCTGGGCAGCTTGCTGTAAGTGTAGGAGTGGATCGGGGTGGCCTTCTTCATGCACGCTTCGGTGCGCTTGAAGTAGTCCGCGCCCGCACTGAGGTTGCTGCACCAGCTGACAAGGTCGTCGCCTGCCATGGTGGCATGCATGCGCTTGGCCACCGATGCCTGCTGCTCGGCGGTAAGGTCGCCTGGCTTGCCGATCGCGATGCAGCCGATCTTGTCGTTGCCGATGTCGCTGCACTGGCCGGTCGGCTTGTCCGGCGCGCTCGTGGTGCTGCTGGCCGAGGGTTCGGGCATGTTCCGTCGGGCGGTCTGGTACTCCTGATAGGAGTCGAGATCGACCGTCGGCGCGTTTTTGTCCGGCTCAGGCAAGGTGATGCTCAGCTGCCTGCCGCGGGTGTGGAATTTCGCCCAGGCGGACCACTCGGTCTCATACAAGCTGCCGTCGAATGCGCTGGTACGGAAGGCATAGGTGGTGTTCGTCTTCAGGTCGCCATAGCGAAGAGTTACCTGTGCCGTTCCGCCGGAAGCCACGAAGTCGGAAACCACCACACCGTAGCTGGCGGGATTGCCAGTTTCGGGGTCGGTGAGCTGGACCTGGTCCTTGGGGTTGCCGTTGGCGTCGGTGGTGTACACCTGGAACGATAGGTCCGCGTCGTCGCCGTCGGCGTCGGTGACGGTGACGGTGTTGCTTAATGTGACGTCGGTGCGGTTGACCTGCCACACGCCGGCCGAGTCCTTGGTGCCCGGCGGGCCAGCCTTGAGGTTCTTTCCGGAGACGGGCCGGTTGTTGTTGGCCATGGTGTGGGCCTCGGGGCCTGCCGCTGGCCGGGAGGACGGGGCGTAGTCCCAGTCAGGGGTGCCGTCGCCGCTGTCGGCGGCGGTTGCGAGGCCGCCTCCCCCGATGAGCATGATGGCCGCAGTGCCTACTGCGATTTTCGACAGGAAGCGTCTTCTTCTGAATAAGCCAAACAAGGTTGACCTTTCCCCTTTTGACCCCATCCCCGCGTATACCCGGGGATGGGGCGTACGAGTGTTCGTGATTGTCGCGCCAGGGATCACTCTTATGTGGCGCTAGCATTGGCCAACAAGGTCCCGAACTGGGGCGATTCACCAATGCGCCCCGAACCGGATGTGACAAGCGGCACGTTCAGGCAGGGTTGTAGACCGGTTCCTTCGACCTAGGCCGTGTTTCCAGTTGTGATCATGTGGTGGGTGGAAGCTCGTCAGCCCCACAGCCAGTCGGATGCGAGCTCGGCGAAGGCACTTTCCTCTCGTGTGGCTCGTAGCGGACGGGTCTCCTTGTGGAACTGCAGAGTCACGCCGGTGACGGGCACTGAGGGGCGGCCGGGGATGGTCATCGAGGTCCCGGCGGGCAGCTTGAAATGCCGGGAGCCCCAGGGGTTCCCCCAGGAGGAGACATGCGACTCCTCCTGCCAGGCCAACTCGGCGCGCATGCCCGCGAATGAGGCGATCGGCGTCTGCTGGGCGTCGTGGAAGACCGCGTCGTAAATGTCGGCATGTACGTCTCCCCACTGTTGCTTGCTGAGCGTGGCAGTGTTCTGCGGCTGCGTGAAGCCGTGGCTGGACAGGATGGCCACGTCGTAGCCCCAGGAGCCCTCACCCGTAGGGTGAACACTCAGGATCCGCAGGTTACGCAGGTAGGCGGCCTGAACGGCGTCCCCGGACGGTGTGCGGCGCGAGCACACGAACGCTGCGGGCCGCCCTTCGCGAGCGGGGGTCGTTCCCACCCGGGCGGCAAGGTCCGCCACGCGCGCGATGTCGTCGACGGTGACCGTTGCATCCAGCGACCCCGCGGCGATGAGCGCCACCGCCTCGTCGTCTGCGCGGGCCACCAGCGTGGACCCGCCCGGCGGCGTGTGGAACTGCCAGATGTCGTCCTCTTCGGTCAACGCTCGGGCAACGGCGTCGAGAAACTGCCGATGTTCGGCGGGTTCGTCTTGCGTCATGGTCGATGATCGTAGGGTTTGCGCGCGTCGCCAACAGTGGCGGATGACTGCAGGCGCTTGATCTTGGGCCAGGGCTGTATCGGGCTTTGATCAATCTGTGGGGCCCAGGGACCGTGTCGAGTTGAGATCACGGGTTTCTTGTTTCGTCGTCCCGGCCGGGCTGGGACGGTAGACAGGCGGGATGACCCGGGGTGATCTCACGAACGACGAGTGGGCTGTGTTCGAACCGCTGCTGCCGCTGGGCGAACGCGGTCCCATTCCTGACCTGCGCAGACTGGTCAACGGCGTGATGTGGCGGTTCCGTACGGGCGGTCCGTGGCGGGACATGCCCGAGCGGTACGGGCCGTGGTCCACCGTCTACGGGCGGTTCCACCTCTGGGCCAGGTCCGGGGTCTTCCAGAGGCTGATGGAAGCGGTGATCGCCGAGGCCGCCGTGCGCGGTCAGGCGGACCTCGGCCTGGTGTGCGTGGACTCCACCGTGGCCTGGGCCCACCATCACGCCGCCGGTATGACGGTCGATGCGGAGCTGCTCGAAGCTCTGGAGAAGGCCGTCGCGGAGAAAAAGGGGCTTCCCCAAAGGGACAGAACGCCCCGGTAGCCGAGCCGGACGAGCAGGCGGATCCCGTCCGCAACGAGCGACGACGCCTGCATCGGCGCCGTAAAGCGCGGCTTCGCGCCGCCGAACTGGGGCGCTCACGCGGCGGGCTGAGCAGCAAGGTGCACCTGTCGGCCGACCGCCGCTGCCGCCCGCTGTCCTTCGTGCTCACCCCCGGCCAGGCCGCCGACAGCCCCCGCTTCACCGCCGTCCTGGAGCGCATCAAGGTACGGGGCCCGATCGGCCGGCCCCGCACCCGCCCCGCCGCCGTGGCCGCAGACAAGGCGTACTCCTCCCGCGCCAACCGCGCCTACCTGCGAAGACGCAGGATCCGCGCGTGATCCCGGAGAAGACCGACCAGGCGGCCAACCGCAAGAAGAAGGGGCGCCGGGGCGGGCGCCCCCTCGCCCATGACACCGAGCTCTACCGTGACCGCAACACAGTGGAACGCTGTATCAACAAGATCAAGGAGTGGCGCGGGCTCGCCACCCGCTACGACAAGACCCCGGTCAGCTACCTCGCCGGACTCCACCTACGCGGCGCGGTCATCTGGCTCCGCACCCTCACATAAAGATCGCAACTCGGTACAGTCCCTAGTACTGCAACGGTGCTTGCCGTGACTGCTGGCCAGATCAGTCGTTGGTCTGGTTATGGGTGGGGACCTTGCTGATGTCAGGTTGTGGGCCGGTGAACTGAGTGCGGTGCACGAGCGGTTCGTGCACCGGTTCAGCCGGGAGGAGCCGCGCCAGTCGGCGCTCGCCTATATGCGGGGGCTGATTGCTCCGCTGGAGCGGAAGAACGGCTGGACGCTCGCGGAAGAAGCCGGACACGCGGGGCCCGACCGCATCCATCGTTTGCTGAACCGGATCGAGTGGGACGCCGACGAGGTCCTGGACGACGTACGTGACTACGTCGTCGAACACCTCGGAGACCGGGACGCCGTTCTGATCGTCGATGACACCGGCTTCCTCAAGAAGGGCATCCGCTCGGCCGGCGTGCAAAGGCAGTACTCCGGCACCGCCGGACGCACCGAGAACAGCCAGATCGGCGTGTTCCTCGCTTACGCCACCGACCGCGGACGCACGCTGATCGACCGCCGCTTGTATCTGCCCACGTCATGGACAGACGACCGGGAAAGGTGCCGACGGGCCGGTATCGACGACAGTGTCGCCTTCGAGACGAAGGTGACCATGGCCAAGGCGATGGTCAGACGAGCGATCAGGGACAAGATCCCGTTCGGATGGGTGACGGCGGATGCCGCCTACGGCTTCAGCAAGGGCTGGCGCTCCGAGCTGGAACAGGCCGATGTCTTCCACGTCATGGCCACCACCCGGCACGACACCGTCGTCACCCGCTGGGCCATCGACCACCCCGTCCACGACTTGTTCCCCGGCCTCCCACGACAGAAGTGGAAGCGCCGCTCGTGCGGCACAGGGGCGCATGGCCCGCGGATCTATGACTGGGCCCGCGTCGAGGTCCGGCCCTGGCACCGCGAGGACCGCCAGCACTGGGTCATCGCCCGCCGCAGCGTCAGCCGGCCCGAGGAGATCTCTTACTACATCGCCTACTGCCCGGCCGGGACCACCCTGGACGAGCTGATCCGCATCGCGGGCAGCCGTTGGGCCGTGGAGGAATGCTTCCAGACCGCGAAGCAGGAATGCGGCCTGGACGACTATCAAGTCCGCCGCTACCCCGGCTGGCACCGCCACATGACTCTGGCCATGGCCGCCCACGCCTGCCTGACCGTCCTGCGCGCCCGCGGACTCGACGCCGACAAAGCAGAAACGGATCCTCCCAGCTCATCCACCTCAGCCTCGCCGAGATCCGGCGCCTGATCGCCCGACTCACAAACCGCCGCCCCATCCCCGTCGACCACATCCTGCACTGGTCGACATGGCGCCGCCGACGCCAGCACCAGGCCCGCGTCAGTCACTACAAACGACGCGGACACAGCCCCTGAAACTGGCCAGCAGTCACGTCAAGCACCGTTGCAGTACTAGTGCCCCATCAAGCAACGTTCGCCGTGGGTGGTCTGCGACGATGACTCCATGGACGAAGAAGTCATTCTCATTCTTCGCGTCGAGGACGCTGCGGCGGCGGTCGCTTGGTACGAGCGGCTGGGCTTCGCCGAGCAGTGGGAACATCGCTTCGAGCCGGGACTTCCCGCGTTCGTCGAGCTCGCCCGGGGCGGGATGCGGTTGTTCTTATCGGAGCACAAGGGCGATGCCCGACCCGACACGTTGGTCTACCTGCGCATTCGTAATGTCGAGGCCATCGCCTCCGAGTTCGGTGTGCAGACCAAGGACGCTCCGTGGGCGCGTGAGATTGAGCTGCGCGACCCTGACGCCAACCGGCTGCGGATCGGAACGCCGACGGAATGACACTCGCCGGCAGCGCGCGGCAGGGAAGCTGGGCTGGTGGCTGAGCGAGTATGCGTCCGCGAGATCGATGACGACGAGGGGAAGCGCCTGCGCGGATCATCCGCAGAGGCAGCGGGTCGGTGGTGATCTGGCGGCGGTGTAGATGCCGAGAAGTAAGTCCGTGCAGTTCATGCGACATGGTGGTGCTCGTGGAGGATGCCGCTGAGGCGGTCGCGTCGGCGGACGTCGAGGTGGGCGAGCCTGTCCGGTTGGACGACCGGCGCGGGTAGCGGGCGGAGAGGCGCGGCGCCTTTGAGGGAGCGGTGGGGTCTGTGATCGTTGTAGAACTGCTCGTACTCGCGTAGTGCGTGGAGCAGGTGGGTCTCGTTCCGCATGAGGGTGCGGTCGGGGAACTCGGCCCGGCATGACCGTACCCATCGTTCTGTGGTGGCGTTCGTGCGGGGTATTCGGACGCCGGTCTGGATGACCTTGATGCCCTCGGCCTGCAGGGGTGCGTCGAAGGCAGCTGGGTAGCGGGGGTCCCGGTCCCGGATCAGGTACTTCGCCCGGGCGTTTGCGTCGTGGAGGTCCATGATCATGTTCCGGGCGAGTTGGGTCACCCATGCCGCGGTCGGGTGGGCGGTTGCGCCGAGGATGCGGATGCGTCGGCTGGTGTGTTCGATGACGGCGAGGACGTACAGGGGTGCCCCGGTCAGGGTCTTGGTTTCGAAGAAAGTCGGCGGCGAGGATGGCGCCGGCCTGCGAGCGTAAGAAGGCCGCCCGGGTCGTGTGTTCCCGCTCGGGTGCGGGCGGGATGCCGTGCTCTTTGAGAATGCTCCACACGGTGGAGGCGGCGACCTTGATACCGAGGGCGCAGAGTTCGCCGTGCACGCGCCGGTAGCCCCGGCTTGGATTCTCCCGTACAAGTCGCAGAACCAGGAGCCGGATGGAGCGGACGGTACGGGGCCGGCCGCGGCGCTTGGGACGGGAGGCCTTCGCGTGGCGGTGGCGGAGCAGGTCGCGGTACCAGCGCAGGAGAGCGTCCGCAGAGACGATCAGGCGAAGCCGGCGGAGCCGTGCTCGTGGGAAGCGGTGTAGCAGGGTTGCGAGGAGTGCCCGGTCGGGCCAGGTCAGCTGTGGACGGTCTACCGTGCGCTGTAGCACGGCGAGTTGGTGGCGCAGCGCCAGAATCTCCAGGTCCTTCTCGCGATCGCTCATCGGCACGAGCCGCACGAACGTGAACATCGTCGACAGGGCGAGGTAGAGGAGTCGCAGCAGCACGGTCAAGCATCTCGCCGGTCGGCGCGGACGCGCTATGCCCAGTCTTGGCTCACGGGAGGAGAGGAGTGATTGTGTTGACCTTTCTCCAAGCTCACCGAGTGCGTGACCTGCACGGACGTAATATCCGGCACCTGCAATGACGGCGCCTGGAGAGGTCGCGGTGCCAGCGCAGCACGGTGTCAGGACGCACGAGCAGCCGCACACGCCGCAGAGCTGGCAACGGTAGCCGGTGCAGCAGCGCCGCCAGGAAAGCCCGGTCGCCCGGGGTGAACCGTACTCGGGCACCGCCGAGTTGGCGTTCGAGCACTGTGATCTGATGGCGGATGGCCAGGATCTCCGCATCCTTGTTCCGGTCGCTCATCGGCAGCAGACGCAGCAGCGCGAACGCGTTGGTCACTCCCAGGTAGGCCAGTCGCAGCAGCACGGTCGATCATCATGACGTGTCGACTACCGGCTACGCGAGAGCGCCTACTCGGGCGACGAGGCCGACGACCGCCAGTCCAGGTGCAGGCTTCCGATCAGGGCGGATGACATTCTCGGCAAGCGCAACCTGGGCGGGGGCGGTCACTTGCTCTCCAGCAAGGGCTCGGGCGTCGGATCGCCTGCCTCGACGAGGGGCAGCAGGTGATGACGGGAGCTGACGGAGCCGTCGCCGTTCATCACGATGCCCTGCTTGAGGAGCTGGCGGGTGAAATCCTCCCTGGCGCGGTAGGTCTTGTCCTCATCGGACAGGCCTTCCGAGGTCAGGCCGAGGTAGACGGCGATGCCCTGGGCGCGCTTGCGCTCGGCGAGGGTGATGATGTCGGACAGCTGCGGCGGCTGGTAATTCTCGACCTTCTCCGCGCGGCGGGCCCACTGGGTGTCGTGGGCGACGTACATCGGGTTGAGGCGGATCGTCAGCGGAATGCCACGCGCGGCGCAGTGCTCGTGCAGGTAGTCGATGGAGGACTCGGCCTCGGCCCACGCCTCCTCGTCGGTCATCACCGGGTCCGGCTTGAACAGGACGTACGCGGTCAGCTCGCAGTCGGCCTCGGCCACCACGTCAAGGCCGCGCAGGAAGACGTCCAGGGGCTCGCGTTTGCCGAGCACCCGCTCGCGCAGGTCCTCGTCGAGGGTTTCGAAGCCAGTGAGGATGTCGAGTTGCTTGCCGCTGTTCTGTGCTATCTCCTTGAGCTGTTCGGCGCGCAGGAACTCCAGGCGGGACTCCAGCACGATCTTGCGCACGCGGGGGAGCTTGCGGGTGGCAGCGGTGATCTGGATGAGTGCGTCGGCGGGGAAAGTGGTCTGGTCGAAGACGGAGCCCTCGTTGGCGATGGTGACGCGCTCGAGGACGCCGAGCGCATGCTTGTCTTCCTCCAGGACATACCGAAACTGGGCGAGAACCCCTTCCTTGGGAATCCATTCACGCGACGATTTGAACGGCAGAGCGCAGAATTTGCACTGGTAGCGGCAGCGCTTGGTGTTGAACAGGATAGCGAGGTCCTGTTCACCAAGGAAATTACGGTGCAGGAAGAAGTGAGGACGGTCGGAGGCGGGTGCCGATTCACCCATGGCCTTGGGTGGACCGAAGGTGCGGTAGAGTCCGCCGAGGAAATCGTCGAGCGGGACGGTCATCGGTTTCCCTTTCTCTTGAGCCGGTGCTTTTTCTTTCGGTCCGGCGCTTCGTAAGGCGTGGGAGCGTCTTCAAGTCGGAACGAGGGTGCTTTCCGCATCGGGCGTGGTGTCGGCGGGGCGCAGAACACGGCGGGGCCAACTCCGGCTCAACGTCGTGAGAATGGCCGACGACGAAGTACCTGTCCTGCGGGCCGCTCGGTGCCAGGTTTGCGAGCATGCCGTACATTGACGCGAAGTAGACGCGCTGCCCCGCGGCGGTGCAGAGCACGACGAGAAAGACAGGAACCGGACCGTCGGCGTGGAGCTAGGCGGCCATGGCGGCCATCTGTAGGGATAAGCCGACGACGAGGCGATGGGATCCGGCCTGCCCGATCCAGGCGTTCACGAGCGTGGGGAGCGCCACTGTCAGGCAGGTGGCGACGGCCAGAACAGTGCCGATCACTGCCTCGGACAGGCCGAGTACGCGCATCGGGTAGAGAACGGAAACGGGAAGGAAGACCCCCGTCCCTACGGCACCGACTCCCGTGACCGCGCAGGTTGCGCGGATTGACCGTGCGACCGACCGGGGTCGCGCCACTGCATTGATGGACCAAAAGGCTCCGCTGTTCGGCGGCGACTGGATACTTTCATCGCCGCTTTTCCGCCCCCCCTTTTTCGGTGCCCTCTGAATTAATCGCTGTTAACGATGCTGTCGACGTTATGGCAACGAGCGGACAGTGCCGCCCTGGAAGTCCGAACAGTAGTCTGTGCAGCCCTCACTATGGCGCACTTCCCGCCGCGTGATCAAGAGGCTGCACGCCGCCTTCCTGAACGCGCACTGGTAAGTTCCCTCGATACCTGTTGGGCCGGATCGGTACAATCAGCAGCACTGGGAACGTTTATGGCCTTCCGGGGCGAACTCGGCTCCGGTGGACAGGATACTTTCACGGTGCGACCTGGCTGCGGTCTCCGCGGCCAACACTCACGACAGCGAAGCGCTGAAGCTCGTGGTGGAGGGCGCCCAAGGAGGCACGGGCCTGTGGAGCTCGGTTATTCATCGCTGCTGGTCGAACGCCACCAACGGCATGCAGAGAGCTGAACCATGTGTGGATGATCGTGTCGCTTCTGTACCAGGTGACTCGACGCCTTCTCCGCACTGCTGAACACCCTCGCGGCGAGCGCGGCCACCGACTACCTGGCCGGCAAGGACGTGACCAGCGAGCTGGTGCAGGCCCAGGCGACGATCGAGAGCTACACCACCGCCTTCTGGTGGTCGGCGGGCCTCTTCGCCGTCGGCGCGGTGATCGCCCTCGCTCTGTTCCGCCGTGGTGTCCCCGCGTGGGACGCGGACGCCGCACCGGTCGCGCACATGTGACCACCACCGCCGCCGCCACAACGACTTCCTGAACCGAAGGGGCGCCGTCCGCGGGGAGACGGCGGCCCTTCTTCCTGCCCGCCCTGGCCGTCCTGGGCGTGTGCGCCGGCCACGCGGCCATCGTCTGTCCACGCCCGGCGCCCGGCCGGGCAGCGCAGAGCGCGTTGCCCGGCCGGTCAGACAGCAGCTCCACGGCATGGGTGCCCATGTCGTAGCAGGGGCCGGGAGCAGGAGCGCCATCGCGGTCCGCGCGCCACCGCGCTGCTCGCCGGCATGGCCATGAGCGGGCTTGAGCCGACTCCTGGGTACGGCGGCTCACTGCGCGGCGTGGTGGGTGCGGCGGAAGGCACCCGGCGTCGTCCCGGTGTGGCGGGTGAAGAACTTGCCGAAGTTGGTGGGTTCGGAGAAGCCCAGGCGGCGGGCGATGATCGCGACCGGCTCGTCGGTGTGGGCGAGCAGCCGCTGGGCCTCAAGGGCGACCCGGGCGTCGATGACCTGCTTGACGGGCTGTCCGGTGGCAGCCAGGCAGGCGCGGGTGAGGGTCTTGACCGTGTAGCCCAGACGGTGGGCGTAGTCCTCGGCGCGGCGGGTGGTGGCATAGGAGCATTCCAGCTGGGCGCGGAAGCGGGCGTAGACCTCGCCGCCGGCGTGCGGGTCGCCGTTCGTCCCCGGCTGCGGCAGCCGGTCGATGTGCAGCAGCACTGTGGCGAGCAGAAGCTGGAGGATCTCCTGCGACACGGTGCCGTCCGGGCGGGTGAACTCGGCGCGCACCCTGCTCAGCAGGGCGGACAGGGCGGCGTACTCGTGGCCGGTGCCCAGTTGCCGGCAGACGGGGCCGTACCACTCGCGCACGACGCGGTCGGTGCCGGCCAGGTGGGGAGGGAAGGTGGGGGTGAACAGCAGGTGGGTGCCGGTCATGGTGCCGGGGCGGCCGAAGCGCTGGACCTGGCCGGGGCGGATCCACAGCAGTGTGCCGGGGCGGCAGTGGTAGGTGACGAAGTCGACGGCGTGTTCCCCGCTGCCCTCGGTGATCAGGGTGACCGTGTGGAAGTCGACCCGATGGACGCGCTGGAGGCTGCCGTCGGCCATCCGCTCGTGCAGGCTGGCCAGCTCGGTCAGCTCGAACCCGGCGACCGGCGCGGTGGGCGGGTTGAAGCCGAACCCGGGGATCGATCCGTCATGGGTGGTGGCGGCGGCTTCGGAGGCCGACATGGAGGACCTCGCTCATGTCCGTCTTTGACCATCAAGGGTCTCCAGCTTATCTCGCGCAGTCGTGGTGCACGGGCGACAGTGTAAGCAACGACGGTTGATCGGATACCGCCCGACCAGGAAGAAGCGCAGCATGAACGGTACTGTCACGGTCATCGAGAAGGGCGCCGTCCGCGTCCACAGCTACATGGCACCGGACGACAGTCTGAATGTCACCACCCAGCTGATCGAGACCCCGGCCCGGATCGTGGCCGTCGACGCGCAGTACGCGCTGGGGTACGCCGACGAGGTCGTCGCTTACGCCAAGGGGCTGGGTAAGCCGATCGACCGGTTGATCGTCACGCACGCCCACCCAGACCACTTCCACGGTGCGGCCCGCTTCGGGGCGCCCGTGCACGCGCTGCCCGCCGTGCGCGACCAGATCGTCGCCCAGGGCGACGCCCAGGACCCGACCGGCACACTCGTCCCGGTCACCGACGTCACGCCGACCGTCGAGATCAGCCCCGGTACCGAGGTCATCGACGGCGTGCCGTTCGTCTTCGAGGCCCTGACAGGCGGCGAGGCGGCCGACGAACTCGTCATCAGGCTGCCCGAGCAGGGCGTCCTGGTCGCCCAGGACCTTGTCTACCACGCCACTCACCTGTTCCTGGGCAACAACGACATCGACGGCTGGCAGAGGGCCCTCGACGCCCTGGCCGCCGACACCTCGTACGACACGATCCTGGCCGGGCACGGCCTGCCCGCCACACCGGCCGTCTACACCGAGTTGCGCGGCTACCTCGCCGCCGCGCGCGAACTGCTCGGCGACGACGGTGAGGCGTACAAGAAGGCGATCCTGGAGCGCTACCCGTCCTACGGCGGCCCGTTCCTGATCGACATCGGCAACCAGTACCTCTTCGGCGCGCAGGGCGCCTGAACTGCCATACAGGACCCTGAATCGCCGTACCGGACAAGGAAAGAGAACAAGGACGATGAGCAGGATCGTGGTGTTCGGAGCCGCCGGAAAGGCCGGCTCCCGTGTCGTCGCGGAGGCTGCCGCACGCGGTCATGAGGTGACCGCGGTGGCCCGGGACCTCTCCCGGATCGCTTCCGTGCCCGCCGGGGTGCGGTTGGTGTCCGGCGATGTCACCGATCCCGGAACGGTTACCGACCTGGCCAAGGGCGCCGACGCGCTGGTGCTGACCGTCGGCGGGCCCGACGCCCACTTGTACACCGATGCCGTGGCGTCCGTCGCCTCAGCCGGGCGGGCCCTCGCCCCGGCCGGGCCTCGCATCCTGCACATGGGCGGCGGGGCCAGCCTTCTCAACGCCGATGGTGTGCGCTTCTTCGACGCGCCTGGCTTCCCGGAGGAATTCAAGCCCTACGCCATCGGCCAGATCCAGGCCCTCGACGCCTACCTCGGCCTTGGTGACGACGTCACTTGGACCTACCTCTCCCCGCCGCCCGTGCACTTTGCGCCCGGTGAGCGCACCGGCCGCTACCGTACGGGCCTGGACCACCCGGTCACCGGCGAGGACGGCCAAGCCCGCATTTCCTATGAGGACTACGCCGTCGCTGTTGTGGACGAGATCGAGAACCCCCGGCACCTCAACCGCCGCTTCACCGTCGGCTACTGAAGCCGTCACCCGGCGACTCCTCGTAGCAGACCGCAAACGACATCCAGGCGGCCGGGTCGGCACGACTGAGCCTCCGCCAACTTGAAGGCGCAGGTCGAAGGGCTGGTGTGACCCGTACTCGGGGGACTCACCCTGGTCGTGGGCGGCAGTCCGCGGAGAAGATCGTTCGTCAGGGGCCGCTCTCCTTAGAGCTCGTAACGCGATCACGATCCGGTCTTCTTGAGGCGTGTGCAGCAGATGAGGCTGCAAGCCAACGAGACGAAGGCGTCGTGGAGTTCGATACGTCGTTCCCAGCGGACCGCGAGGCGTTTGAACTGGTGGAGCAGGGCGAAGGTCTGCTCGGCGACTAGCGGAGCTTGCCCAGGCACTTGATGTTCGGGGAGCCCTTGCGGGAGATCAGCGCCTGGATGCAGCGGCGTCGCAGCTCACCGCGCACAGCCTTCGAGTCGTACGCCTTGTCGCGGGTCGTCGGCGGTGCGCGCCCCGAAGGCGCGATGTCCTTCGGGGCGCGCGGCAGGGGTTCGGGTTCAGGCGTTGTAGCCGCCGTGGGCGTCCAGCACCGCGCCCGTGACGTACGACGCGGCGGGGCTCGACAGGAAGGCGATCGCCGCGGCGATTTCGTCGGGGTGCCCCATGCGTTGCAGGGACAGCGAGCTGACCAGGGCCTTGAGGGTCTCGGGGCCCGGCCCTTCCATGCCTCCCTCCATCAGTCCGGCTTCCACGACGTTGGCTGTGATGTCCCGGGGCCCCAGGTCCCGTGCGACCCTGTGCGACTCTGTCGCCCGATTCGGTCGGCCTGGTGAAACCGGTGGGCCGCTCACGACGAACGCGCAGGTGAGGCTGATCGAATCAGGTCTCACCACGATTCGGGCGACAGAGTCCTGGCCGTTCAGAAAACCATCGCTGCTGGTCAGGCCGCGTAACTGTGCTCATTGATGAGGCTGCCGAAGATGCGCGTGCGGTGTAGGTGTGGCGGGGTGCTTGTGCCAGCCAAGACTGCGTCGAACGACTTGGTGTACTTGCTGTCCCTGTCGTGGACCAGGAAGCTGCGACGGATGCGCTTACGGGAGCACCGCGTTGACGCTTGGCGGCTGCCGTGTGTGGCCTCGTAAGGAGCTTGACAGCGCTGCGCTTGCCGATAACTTCATCCGTGCAGGTCATGCGGCATGCTGGTATTCGTGGAGGAGGCCGCCGAGGCGATCACGTCGTCGTATGTCGAGGCGGGCTAATGTGTCCGGATTGTCGATCGGCGCAGGTAATGGGTGCAGTGGGCGGGCGTTGGCGATGCCCTGGTGTGGTCGGTGTCCGTTGTAGAACTGCTCGAACTCGCGCAGGGCGTGGAGCAGGTGCCGGTGATTCCAGATCAAGGTGCGGTCCAGGAGTTCCCGTCTGCAGGTCTGCACCCACCGTTCCATGATCGAGTTCATTCTCGGCATCTGAACGCCGCTGAGGACGACCTCGACCCCCGTATCCACCAGGATGGCATCGAACAGGTCGGGGAACTTCCCGTCCCGGCCCCTGATCATGTAACGCGCCCGGCAGCCTACGTCCTCAAGATCCATGACGAGATTCTTCGCGGCCTGTGCCACCCACGCTGAGGTCGGGTGCGCGGTGGCACCCAGGACCCGGATCCGTCGACTGGCATGCTCGATGACGGCCAGCACGTACATCCGAGCCCCGGACAGCGTGACCGTTTCGAAGAAGTCACAGGCCAGCAGGGCCTCGGCCTGGGGAGCGCAGAAAGTCCGCCCACGTGCTGGAGGACCGCTCGGGTGCCGGATCGATGCCGGCCTCCTGCAAGATCTCCCAGACGGTGGAAGCGGCCACCTTCACGCCCAGGACGAGCAGTTCACCGTGCAGGCGCCGGTACCCCCAGCCAGGGTTCTCCTGCGCCAGGCGCAACACCAGGGCCCGCACCGAGTGCACGGTCCGAGGCCGTCCCGAGCGCCTGGGCCGGGAGGCGACAGCATGGCGGCGTGCAAGAAGGTCACGGTGCCAGCGCAGCACCGTATCCGGACGCACCAGCAGCCGCACCCCGCGGAGCACGTCCCTGGGGAGCTGGTGCAGCAGCGCCGCCAGAAATGCCCGGTCGCTCGGGGCGAACCGCACCCGCTCCCTGCCGAGTTGGCGCTCCAGTACCATGATCTGGTGGCGCAAGGCTGGTATCTCGACAGTCTTGCCTCGATCGCCCATCGGTAGCAGGCGCAGCATGGCGAACGCATTCGCCACGCCCAGGTAGGCCAGTCGCAGCAACACGGTCGATCATCTTGCCTCGGTAAGCGCCAGCCTCGCGAGAGCGCCCGCTCGGGCCACACCGCCTCCCACCAGGGCGGATGATATTTTCGGCAAGCGCAGGGTCACCCAGCTCGCCCGCAATCTGCTCATGGACCTCGGAGACAGAGCTGGGTGCTTCCGGTTCCTCATCCGCGACCGGGACAGCAAGTTCACCGCCGCATTCGACGCCGTCTTCGCCGGCAACGGCATAGCCGTCATCCCGACTCCGCCGCAGAGCCCGCGGTCGAACGCGTTCGCCGAACGATGGATACGCACGGCCCGCGCCGAATGCACCGACCGACTCCTCATCACCGGCGAACGACACCTCCGTGCTGTCCTCACCACGTACGCCGAGCACTACAACACCGGACGGGCCCACCGCAGCCTCGATCTACGAGCCCCGGACGACCACCCGAGCGTCATCCCCCTGCCTGCTGCCGTAGTTCGACGGCGACAGCTACTCGGCGGCCTGCTCAACGAGTACCACACCACGCCACCCCAACGACTTCTCCATCCACAAGAAACACCCAGCTCAGCGGCCTGATCGGGATATTGACACCCTTCAGGCCGCTATGTGAGCGCGGAGACCGCAGCGTCCTTCACCGGCAGAGTCGCCGGGGTCTACGCCAAGGACGGAATCGTCGACGTGGACTGGTTCACGTACGAGGGGCAGGACGCGAAGCGCTGACGCTCCGTCGCTGGAGCGCTTTGCGGGCCACGGCAGAAACGTGGTGTCGGACGATCCGGTAGCAGTCCATCGTTCGGAGCCAGCACGGCGACAGTTCCTGCACACTCAAGTGTCGACCTTGCTCGCCGTCGACTTCTGGTCTGCACATAACCCCGCCACCTGCGCCCGGGTTGTCCGTCCTCGATCACTCGCGAGGACCGTAAAGCCCTGGATCGTGCGCTCTCGGGAGGAAAGCCAGTTCAGATCGCGGGAAGCGTGTGGAGCAGTTGCTCGGTCCAGATGGTCTTGCCTGAAGCGCCGTATCTGACCCCCCAGCGGTGCGTGAGGGCACTGATGAGCTGAAGGCCGCGGCCGTCCTCGTCGGTGTCGGAAGCCCTGCGGATGTGGGGGGTGGTGAGGCTTCCGTCGGAGACCTCGCAGAAGAGACTGCGCCCGCGCAGCAGACGCAGGGCGACGGGACCCCGCGCGTGGCGCACGACGTTTCCGAGGAGTTCACTGACGACGAGTTCGGTGGTCATCACAAGATCGTCGAGATGCCAGAGGGGGAGTTGCCCACGGACCAGTTCACGTGCCCGGTGCGCCGCCGTGGGAGCTGTGGGAAGAGGCCATACAGCGACGTTCTCGGCCGTCAGCGCATGAGCGCGTGCGAGGAACAGCGCGGCGTCGTCCCTGCCCTTCTTCTGGGTCGGCAGAAGGGCGGACACTATGGTGTCGCAGAGGGTCTCCAGGCTGGGCTGGTCCTCCTTGCCTATCGCCGCGTCCAAGATTCCGGTGAATCGGTCGACGCACTCGTCGATGTCCTGGCCGGGTGATTCCACCAGCCCGTCGGTGAACAGCGCCAACAGGCTGTTGGCCGGTACTTCGATCTGGACGACGTCGAACGGTGGTGTGGCGGCGCCCAGGGGAGAGTTCGTGGGGACCTCGGGGATGTGCACGGTGTGATCGGGGTGGATGACGACGGGCGGAAGGTGGCCGGCGGAGGCGAACTCGCACAGGCATGTCGTGGGGTCGTAGACGGCGTACAGACATGTGGCGTAGGAGTCATCGCTGAGGTCGCTGACGAGATCGTTGAGATGGGTGAGAATCTCGTCGGGAGGGAGTTCGAGTTCGGCGAGGGTGCGTACGGCCGTGCGCAGGCGCCCCATGGTGGCCGCTTCTGACAGCCCGTGGCCCATGACATCACCGATGACGAGCGCGGCGCGTTCGGCGGACAACTCGATGAGGTCGTACCAGTCACCGCCGACATCGAGGCGGCGGTCGGCCGGCAGATAGCGCGCGGCGGCGCCGATCGCGAGCAGCGGGGGAAGCTTCTGCGGCAGCAGGCCACGCTGTAGTTCCTGTGCGCGGTTGTGCTCCGAGTCGTAGAGCCTGGCGCGCTCGAGTGCCTGGGCGATGAAGCCGCTGAGTGCGGTGAGCAGGGTCCGTTCCTCGCCGCTGAGCGGTTGCCGCCCGGCGAAGTCGATCACGCAGCATCCGGTCACCTGGCCGGAGACGATCAGAGGCAGGAAGGCCCAGGACTGGTCCTCGTCGGTGACGAGGACCTCAGCGGAAAGCGGGTAGCGCGCCCTGTGCTCCTCCGTGGACGTGATGAACAGCGGAACACGGGTGGTGAGGACTTCCGCCACGGGAGCGGTGAAGGGTGGGCCATGTGCCCGAAAGACATCCAGTTGGGTTTCGCCGTATCCGATGGAGCCGACGACGCGAGGGGAGCGGTCCTCCATGGTCAGGACGGCCAGCCTGGTGGCTCCGAAAGGTGCGAGGACGTGCTCCGCCGTCGCCTCCACGACGTCCCGCATGGTGATGGCCTCGGCAAGCGCCCCGGTCAGGCGCGCGATACGCGCGGAGCGTTCAGCGGCGCTGCGTTCCGCGGCCTCCCGTTCCGCGTTCCTGATTTTCCTGTCGGTGATGTCGGTCGAGTAGATGGTCAGCCCTTGCGGCACCGGCACCAGGCGCAGGCCGTACCAGCGCTGGTTGGCGGACGAGCACAGCTCGGTGCTCACCGGCCTGCCCTCCGAGATCGTGCGCCGGCACATCTCCTTGAACCCGGGTGTCTGTGCGGCGGGGATGGCCCACAGCGAGCGGTCTCCGGTGTCGGGAACCGGTCCGAGTGCCCGCTCCGCTTCGGGGTTGGCGAATGTGATTCTCCAGTCGGCGTCGACGGCAGCGAATCCGTCCGTCATGTGCCACAAGGCATGATCGACGGCGTCCCTGGCGGCCCGAGTGTGGGTGGTGTCCCACACCGTGCCGACCATGTGCGCCGGCTCTCCGTCCGGACCTATGATCACCCGGCCACGGGCCTGCGCCCAGCCCGAGGTCCCATCGGGGCGCCGGATGCGGTACTCGACCCTGTAGAGACTGCGAGTACGGATCGCCTCGTCAGTGCCCGCCATCACCCACGGCAGGTCATCGGGGTGCACCATGTCCACCCAGGACTCGATCCGCCGGTCGTAAGTGTCGGGATCGATGCCCAGCACCCGCATGGCCTGCTCGTCATACAGAAGCTCGCCGGTGCGGATGTTCCAGTCCCAGGACCCCACGCTGACCGCCTTGGCGGCCTCGCTCAGCCGGGAGCCGCCGTCCTGTTCCAGCCACCATTCGGACGAGGCGCCGCGGGGAGCGGTGAGCGAGCGGCCCAGATGCCGGGCGACGAGGTGGGCGACCTCTTCCAGAAACGAGCACTCTTCGGCCGTCGGCTCCTCTTCCAGACAGATGACGGACAAAGTGCCCAGTACTCGCTCCTGCGACACCATCGGGACCACGACGATTCCGGACACGGCCGCACTTCCCGAGTGTTCCGGAAGCGGGTCCGTGCCGGGGTCGCGGCCGCTGTCCCGGGTCCGTATCGGCCGCCATCGGCACTTCCCGTCCAGCATGCGGTCGACCGGGCTCGTCGGATGCCGGACAACGCGGTCCTCCCATTGCCGCGCTTGCGTTGCGGGCAGGCTGTCGACGGCGAGCAAACGCAGCCCCGCCCCCGCCCAGGGGCCCGTCAGATGTGCCATGCTGCCCAGGCCTCCGAGTTCGGCGACCACATGGTGCAGGGCGCAGCTCAAGGACTCGGACTCCGTGACGTCCTCACCAAACGCGGCAAGCGCGCGAAGCCTGTCCTCCCTGGACCAGCGTGTTATCCGTTTCGTGCTATGCGTGTTTCGTGCCATGGACTGCTACCGATCATCGGCCTGGCCGGGCTGCGTAGGCGAAGCAGAGGTCCGCTTGCGCATCTAAAATTATGCTATAAGGAGCATCTGGGTGGTAATCGCGTCATGAAATGTATTGGCCGACGCGGGGTTAATCAGTGCTCTGAAACACCGGCGCCGCCGCCCACGGCAGCGGCGGGGGTTCGGATGGGCGCCCTCGCTGGGCATGTCCCCGTCCGACGGCGTCGGCCGCTACTGAGGGGTGGAACCCGGTGCCCGAGGTGGGCTGACAGCGGCCGTGCCAAGGGCGGCCAGTTGAGTCCTGGCTGATGGCCGGAGAGAAATGGCTTTCATCCACTTGTCGCGAAGTGGTGACGCAGGGTGATGGAAAGGATCGGTCGGTGTAGAGGACGCGGCGGCGAAGTAGATCGAACCCTGCGCGATCCTGTTGCCCATTGTGGTTATGCGGTGAGGGTGTGCTCGAGTCGGGTGAGGTGGCTGGTGCGGGTGCGGTCCAGGGGGCGGTCGTTCACCAGGCATTCAGGCGGATCAGGTTGAGTGCGACGGCGGAGTAGATGTGTTCGAGGTGGGTCTTCGCCAGGCCTCGGTAGCGTGTGCGGCGTGTGCCGGTGACAGCGGTGGCCTGCCGGATGGTGCCCTCGATGCCGGCGCGTAGGGCGTAGTCGGTGTTCCAGTCCCTGGTCTTCTGCCGGGCTCGGGGTGTGCCGGAGTGTCTCGGTCATCTGTCTGGGATGGAGGGAGAGTTGGCGGCGGTTCTTCTTCGCGGTGGTGCACTGGGGTTTGAAGGGGCAGGGGATGCGGTCGAGGGCGGCGAAGGTGACCACGGTCTTGGGGATACCTTCGCTCACGACGGGGTTCCAGGTGGCGCTGGTATGTCCGGCGGGGCAGGTGGCCTTCCCGGCTTCCCAGTCGATGGTGAAGTCGGTGGCGGCGAAGTCTGCTTGGGCTTTGGCCTGCCGGGAGGTGTCCAGCAGGACCGGCGTGATCAGTGCGATGCCGTAGGTCTTCACCGAGCCGTGGATGAGTTCGGCGGTGGCGTAGCCGGAGTCGGGACAGTGCTCATCGGGGAGCAGGCCGCGTTGCTAGAGCGCGTGGTGGACGGCGTCGAGAGCCTTGCTGTCCGGCACTGTGGAGTGGGTGGTGGCGATGTTCGTGATCAGGTTCGGGTGTGTGCGTTGTGGGGCTCGGATATTCATCGCTGCTGGTCAAAACGCCACGGCCTCCGCGTAGCGCTGCGATCCTGGTTGGATGGTCGTGTCGCTTCTCTACCGGATGACTCGACGTCTTCTCTCCGTCCCACCAGTGCTCCTACAGCGGGACACCTCGAAGGAAGCTGAGCTTCTCGTCCTGCGGCACGAAAACGCTGTGCTACGACGCCAGCTGCAGGGGTGGGCACGGTACGAGCCGGCGGACCGTCTCTGGTTCGCAGCCCTGTCCTCGCTGATCCCCCGCCGCCGCCGGGCCAAGGTCTTCCCGGTCACACCGAGCACGCGGCTGGCCTGGCACCGCAACCTCGTCGCCCGCCGATGGGACTACTCCCGACGACGCCGAGGTCCCGGAAGGCCGCCCACGCAGGCCGCCGTCAAGAACCTCGTGCTGCGCCTTGCCCGTGAGAACAGCCGATGGGGCCATCGCCGGATCCAGGGCGAACTGGCCCGGCTCGGACACCCGATCGCCGCCTCCACCGTCTGGCAGATCCTCCACACCGCAGGAATCGACCCCGCACCACGCCGCACCGGCCCAACCTGGTGCGAGTTTCTCTCCGCGCAGGCCACCAGCTTGATCGCCTGCGACTTCCTCCATATCGACACGATCAGCCTGCAACGTCTCCACGCTCTGGTCTTCCTCGAGCACCGCACCCGGCGCCTGCACATCGCCGGCGTCACCGCACACCCGACCGCGGCCTGGGCCACCCAGCAGGCCCGCAACCTCGCCACCGACCTCGGCATACGGATGGACTCGCTGCGCTTCCTCATCCGGGACCGCGACAGCAAGTACACCGACGCCTTCGACGCCGTGTTCCAGGCCGAGGACATCGAGATCGTCAAGACGCCGGTCCGTGCGCCGAAGGCCAACGCCCACTGCGAACGAGTGATCGGCACTCTCCGCCGAGAAGTCCTGGACCACATACTCATCCTCGGTGAAGGTCACGTGCGCCGGGTCCTGGCCACGTACCAGAGGCACTGCAACGCGCACCGCCCCCACCGGGCCCGATGCCAACTACCTCCCCAAGCTCACGGACAACCACCTCCAGTCCTGAAGCCGGCCAGCCGCAAAGTCCTGCGCACTCGCGTCCTCGGCGGTGTGATCAACGAGTACAGATATGCCTCTTGACCAGGAGCGACGATTATTCGAGCCCCGCAGGCAAGACTGCCCTCCGCAAGGGCGCAGCTACCGGACCGGACGGTGCGTCTGCGTCCGCGGTGTTGGATGTTCCGCTGCCGGTCAACGACTGCACCGGCGACGAGGACGGCTACTGGTACGCCACCCGCACCATGCAGTGCCAGATCGACCCAAATGTGAAGTACTCCTACTACAGCAGCGACAACAAGCTCCTCGGCACCGCCCTGTTCGCCACCGCGCAGCAACTGGACTTAGCCACGAAAAGCCTGCAGCGGACTGAGACCGACCAAATCACCATGCTGTCCTCTACCGGAACACTGCCTGCCGGTCTGAGCGTGTCATGGACCACCAGCTGTTCCTCCCCCTGCGCCCCTGGAACCACGAAGCTCTGGACCTCGGCCCCCATCAGCCTCGGCCAGAACCTCAAGAAGACCTACACACTCACTGACCAACCCTCAACGGGCTACGACTACATCGACCTCGACTACCAGCTCTCCATCGGCTCACCCGACGCCATCGACCTGCTGCCGCCGATCACGTGGGGCGGAGCCGAAGTCCGCTGCGACAACAAGATCTCCGTCGCCGACAAGGCAGGATGCGTGGTGCCTTGGTACACCCCGACCCTGCAGATACCCCGGTCTCAGTACGGCTCTTCGGCGGACATGCTCGAGTGGGCCCAGAACAATCTCTCCGGCCACTGGGGACTGCGCGGTACCGGCCAGCCACTGCACCGGCTGAAGAACTCGTCTCAGCAGGCAAGCAACCGTCAAGCCATCTGTGGAACTTCCAAGTTCACCAAGGACCCCAATGTTCAAGACGATACCTGCGACGAGTTCCCCTTCGCCGGCACCTACGAAAGCGGTGCCCTCAATAGCGTCGATCACGGGAAGGACTGCGCGCAGGTGACGGCAGTACGAGCAGACACCAGCGGGAATCTTGCGGTGGACTGGCCCACGGTCACCCCCACGGGGACAGTCAGCGGCAGCGAGAAATGCGTGCGCGGACACATTCCCGGAGCGCTCAACTCGGACGTGGGCTCGGCCTACGGCGTCTTCGTCAAGGACAAGCTGCTTGCGGACAACGACCCGTTCTGGCTGAGGATCACCTTCTGAACGACCGTTCCTGAGGCGGCGAACCGCCCGGCGGTCAGCCCTGCAGGTGCAGAAGGCTGACCGTCGGCAGGGGACTCTTGGCTACCTCGGACGACAGTGCCAGGCCGAACTCACGCTCCAGCATCAGCAACGCAGAAACGGATGGCTCCCAATCGTCGGACTCCCAATTCTCCTCCAGGAAGAATCCTGCATCGGTGAGGGCACGGTTGAGGAAAGAGGGGTCGGCCCCCTCTGCCGGCTGGAAATGCCAGGCGTCGTAATAGGCCAGGAGTTCCCCGGATTGCGCATGCGCAATCCGGGTCGTACTGTCGAGGAGTTTCCAGATCGAGACAGCCTCGGTGCTCATGGACAGGCGGGTAAGCACCAGGGACTGGAGCAGCACGCCGTGATCGTCGACGTCAATGAGAAAGGTCCACTCACCACTGCGACACACCCGCGCCGCAGGCGTCTCCGCACCCGACCCGAAGCGTTGCAACGCCTCGTCGGGCGTGCACAACGGGTACGGCGCCTGATCAGTGACACTCAGACGAGACAGCACCTCGTCCGGCGAGAGCCCGCGCACACACGTGATGCCAAAGTGGTCCCAGGGCACACAGCCGACCAGTGCAGATTCCGTCACTGCCCGTCATCCTTCGGCTCAGCAAATGTTGGCATGTCGCGCCCTACGCCGTTCGCAAAGCCCAGGGCTGACACGCCAGTTCGAGTTGGTCAAGCACACTGTAGCGTTGGTGCCCGTCCGAAGACGGTGCAGCAATATGTCAGGGCATGTTGGTGAGCACGGCTATCGCAGCCTGAAGAATGCCGGGCTGGAGGGACGACCGGGGCATCGACTCGATCGACACGCTGGAAGCGCTGATCCGCTCCGAAATCAAAGCGTTGGCTCCGCCCGGCGCACGCAGGGCGATTGCAAAGTTCGCTGATCGTGCGTTGGCCTCGATTCTTCCGAGGGGTGACGGCGACGTTGTGGACGACTGGCTGCCCGGTATGCCCGTGCCGTGTCGGGACTGGCCGTCGAGTGTCGCTGCGGGGGCGTCGGGTTCCACGGGCCCGAGGGTGGTGCGGTCCTCTCCTCTCCGCTGTCGTCGGGGCGGTGGCCAGCCGTCAGGTGAGGGCCGGAAGCTGGGTGGCCCTGTGCTTGCCGAGAATGTCATCCGCCCTGGTCGGAGGCATGTATCGGGACTGGCGGTCGTCGGTCTCGTCGCTCGGGTAGGCGCTCTCGCGTAGTCGGTGGTTCACGCCTCATGATGTTCGACCGTGCTGCTGCGACTGGCCTACCTGGGCGTGACCAACGCGTTCGTGCTGCTGCGTCTGCTGCCGATGAGCGACCGGGACAAGGATGCGGAGATCCTGGCTCTCCGTCATCAGATCACGGTGCTCGAACGTCAACTCGATGGTGCCCGACTACGGTTCACTCCGAGCGATCGGGTGTTTCTGGCGGCGCTGCTGCATCGGCTGCCGTTGCCGGCTCTGCGGCGTGTGCGGCTGCTCGTGCGTCCTGACACGGTGCTGCGCTGGCATCGCGACCTTGCAAGACGTCGGCATGCCGCCTTATCGCGGCCCAAGCGACCCGGTCGGCCTCGTACCGTGCGGTCCATCCGGATTCTGGTACTGCGCCTGGCGAGGGAGAATCCAAGCTGGGGCTACAGGCGTCTGCACGGCGAGCTGCTCGTGCTGGGAGTGAAGGTGGCCGCCTCGACCGTATGGAAGATCCTCAAGGAATCCGGCGTCGATCCGGCGCCCGGCCGGAGCTCCAGCACGTGGGCCGGCTTCCTGCGCTCTCAAGCTGACGCCCTCCTGGCCTGTGACTTCTTTGAGACGGTCACCTTTTCCGGCGCGCGGATGTATGTACTCGCGGTGATCGAGCACAGCAGCCGTCGCATCCGGATTCTGGGCGCCACCGCACACCCGACCACCTCCTGGGTAACACAGGCGGCGAGGAACCTGGTCATGGACCTCGAGGACGTAGGCTGCCGGGCACGGTTCATGATCCGGGACAGGGACGGGAAGTTCCCAGTCCTGTTCGACGCTGTCCTCAAGGGTGCGGGGATCGAGGTCGTCCTCACCGGTATCCAGATGCCGAGAGTGAACTCGATCATGGAAAGGTGGGTGCAGACCTGCAGACACGAGCTCCTGGACCGGACCTTGATCTGGAACCAGCGCCACCTCCTCCACGCCCTGCGAGAGTTCGAGCAGTTCTACAACTCCCATCGACCGCACCAGGGCATAGCGAACGCCCGACCGCTACACCCACTGCCGTCACCAATCGACGATCCGGACAAGCTAAGCCACCTCGACATACGACGCCACGACCGCCTTGGCGGCATCCTCCACGAATACAGACATGCCGCGTGACCTGCACGGACGAGACATTCGGCAAGCGCAGGCTTCGTCCGAGCGCAATGAGATCCGGCACACCGCGTATGTTGCTCACAACTCCGTCCCATAACCTCGTGCATGGAGACGTCGGATGCCACGTGTATCCACTCTGAGGAGGCGATGGTGTTCGGAAGGGACACGCGGTTGTTCGCGGGCGCCGTGATCGTGGCCTGCATGGTGCTCGTCGGCCCCAGCGCACCAAGCGGCGCGCCCCTCGCCAGGTCACTGCCCGTCGATGCCGTCAGGGGTGTCGTGCCGAACCGGGTCATGACGTGGAACATCTGCAACCCCTGTGAGGAAAGCAACGTCGACCGCGCAGCGGAGATCGCCACGTATGCGCCCCAGGTGATCGGCCTACAAGAAGCGTGCGTGCGTGACGTCGAGAGGATGCGGGACTATCTGGAGGGCTTTTACGGGCTGGTTTACCACGTCGAGTACGGGATGGTTCTTCGGAATTGGGGCCGCTGCGGGGGAGCGCCGTGGAGTCCGGGGGCATTCGGGCAAGCGGTCCTCTCGGCGGCGCCGATGACGAACCCGGTCAACGTGGAATACCCCGACGGCGGATCCGAGGACCGTGGGTACATGGCAGTCACCACCAGTGTGGGCGGCCGGTTCGTCCGGGTCTTCAACACACACCTCGCTGAACGACGTCAGGAGGCAGTCCGGGCAGACCAGACCGACGTACTCGCCGCAGACGTGGCCCGGCACGACCGCGCGATCGTTCTCGGCGACTTCAACGCTGTGCCGGACGCTCCCGAGCTCACAGGGATGTGGGCACTGGCCGCGGACACAGACCCCCAGTGTCATCCCTCGTCTACCGGAACCTGCAAGCCGACCACCGACTGGCAGAGCAAGTTTGACTACATTTTCCTGCGAGGCATCGTCCCGCTCGAGCACCGTGTGCTTCCGACCCCGTACTCGGACCACCACCTGCTGCACACCGACCTGGACCCAACGTGAGTGGGCGCCCGCGGCTTGGAGGTCCATGGCCATATTGCGGGGCGGCCTGGGTGACTCAGGCCGCGGTGGGGTGTGCGGTTGTGTCGAGGATCAGCACGCGGCGGGTGGCGTGCTCGATCACCGCGAGGACGTACAGCGTCGCTCCGGTCAGGGTTTCGGTCTCGAAGAAGTCGGCGGAGAGGATGGTCTGGGAGCGTAGGAAGGTTGCCCGGGTGGTGCGTTGGCGTTCGGGTGCGGGGTCGATGCTGTGGTCCTTGAGGATGTTCCACACGGTGCCGGCGGCACCCCGCTGTGCTGCGGGCGGTGAGTTCGCCGTGGATGCGCCGGTACCCCCGGCTGGATTTCTCTCGTGCCGGCCGTAATACCAGGGCGCGCACGGATCGTGCAGTGCGGGGTTGTCCCGGCCGTTTGGGGCGGGAGGCCTTCGCGTGGCGGCAGGGCAGTAGCTCACGGTGGCAGCGCAGCTGCCCTTGCCGGAAATCTCATCCGTGCAGGTCACGCTGCATGTCGGTATTCGTGGAGGATGCCGCCGAGGCGATCGTGTCGGCGTATGTCGAGGTGGGCTGACGTGTCCGGATCGTCGATCGGTGGGGGCAAGGGATGCAGCGGTCTGCCGTTCGCGATGGCCTGGTGTGGTCTGTGTGCGTTGTAGAACTGCTCGAACTCGCGCAGGGTGGGGAGGAGATGTCGTTGGTTCCAGATCAACGTCCGGTCCAGGAGCTCGCGGCGACAGGTCTGTATCCACCTTTCCGTGATCGAGTTCATCCTCGGTATCTGGATGCCGCTGAGCACGACCTCGATCCTCGCGTCCTTGAGGACGGCATCGAACAGTTCGGGGAACTTCCCGTCCCTGTCCCTGATTCATGAACCGTGTCCGGCAGCCGAGGTCTTCGAGGTCCATGACGAGGTTTTTCGCCGCTTGGGCTACCCAGGATGCGGTCGGATGTGTGGTGGCGCCCAGGATTCGGATCCGGCGACTGCTGTGTTCGATCACTACGAGCACGTACATCCGTGTCCCCGAGAGGGTGACTGTTTCCATGAAGTCGCAGGCCAGCAGGGCATCAGCCTGGGTGCGAAGGAAGTTGGCCCAGGTGCTGGAGTTCCGCTCGGGTGCTGGGTCGATGCCGGCTTCCTTCAGGATTTCCCAGACGGTGGACGCGCCCACCTTCACCCCCAGTACGAGGAGCTCGCCGTGCAGGCGTCGGTACCCCCAGCTCGGGTTCTCCTTCGCCAGGCGCAGCACCAGGATGCGGATCGAGCGCACTGTAGGGGGTCGTCCCGGGTGTTTGGGCCGGCAGGAGGCGGCGTGGCGGCGTGCGACGAGGTTGCGGTGCCAGCGCAGTACCGTGTCGGGGCGTACGAGCAGCCGTGACCCTCGCAGGACGGGCGGTGGCAGCCGGTGCAGGAGCGCTGCCAGGAATGCCCGGTCGCTCGGGGTGAACCGGATCTTTTCCTTGCCGAGTTGGCGTTCCAGCACGGTGATCTGGTGGCGCAGGGCGAGGATCTCCGCGTCCTTGTCCCGGTCGGTCATCGGCAGCAGGCGAAGCATCGCAAACGCGTTCGACACACCCAAGTAAGCCAGTCGCAGCAGCACGATCGATCATCACGGCGCGCTGACGGCAGCTGCGCGAGAGCGTCGGCTCAGACGACCGCGGCCAGATTTCGGGAAACCCGATGCACCGGCCCCTACCAGGGCGGATGAGGTTTCTGGCAAGGGCAGCGGTAGCGGGAAGCGGCGTGTCGGATTCCCGCAGCGCGTAGTTGTCACTGAACCGAGCGCGGGGATCGGTGCCTCAGCCCACGAGAGGGCCGATGTCCTCGTCATACAGGTTGATTACTTCGTTGCTGTGCGGGTGCAAGACGTAGCCGCAGTCCAGGCCAGAGGTGGTCCGGTCCGTGGCGGTCATGCACTCTGCGGAGAGCCGTTGGCGGTGACGATGTTGTTCAGCTCGAGGCTGGAGGAGTGCTCGCCGTCGAGGAGTTCCTTGCAGAGCGCATCGGGCGCACTGTCGAGGAGATCGGTTCCCAGGTAGGACCGGCCGACGGCCACGTCGTAGATGAGGTGTTGCGCCATGGCCTCGATGTCGCCGATGAAGCGGTGTTGCTAGGAAGCCAGGGGGAGAGGGACCCCCGGGTCGTCGACGGCATCGCAGCCAAGCGCCGGGTCATCACGTTCGACAACAGGGGCGTCGGCGCTTCCACTGGTTCGACGCCGCGCACCATCCAGGCGATGGCGAAGGATGCCGTCACCTTCATCCGGGCGCTCGGGTTCGAGTACGTAGATCTTCATGGCTTCTCGATGGGCGGCATGATCGCCCAGGTGATCGCGCAGACCGAACCGCAACTCGTCCGCAAGCTGATCCTCACGGGTACCGGTCCTGCAGGCGGCGAGGGCATCAAGAACGTGACCCGGTTGTCCCATCTCGACACCGTCCGAGGACTGCTCACCTTTCAGGACCCGAAGCAGTTCCTCTTCTTCACCCGCACCGCCAACGGGCGTCGGGCCGGGAAGGAGGTCCTGGCCCGGCTGAAGGAGCGCACCCACGACCGGGACAAAGCGATCTTCCTCAGGTCGTATGGTGCCCAGCTCAAGGCGATTCACCGCTGGGGGCTGGAGCAGCCCCACGATCTCTCCGTTATCCACCAGCCTGTACTCGTTGCAAACGGTGAGAGCAACAGGATGGTTCCGTCGAAGAACTCGGCCGACCTGGCGCGGCGAGTGCCGAATGGTGAGCTGGTGATCTATGCCGATGCCGGTCACGGCGGCATCTTCCAGTTCCATCGGCAGTTCGTGGAGACGGCTCTCAAGTTCCTCGAACGGTGACAGGCGCGAAGTGCGGCCATTGCTTGTGCGGATCTTCCAGCTCTTCAGCCGGGCGAAGACGTGGCCGACGGTCACGCCTGCCTCTCGGCTGGTCGGCATGAGGCGAAGTTGGAGAAGCCTCCCGGTGACTCTGGGGGCGGCCGTGAACTGTCCCCCTCAGCGCATGAAGGTGAGGGCGCTCTCGATTCCCTGTTCAAGGACCTCATCGGCGAACTTGCGGTCGGAGAGAGCGCGGGACAGTTGCAACGCCCCCACCATCATGGTGAAGAGCCCGATGGCCTTACCGCGAGCGGACTGCGGATTCTCGGGTGCCAGACGGGCGGCGATCTCTTCCACGATGTCCCGCGCGCCGTCGGTGTAGGCCTGCTTGGGCCCGTCCCCGCAGCGGCCGATCTCGTCGAGCAGGGCGGCGGACGGGCACCCGTCGCCGGGGTGGTCCCGGTGTTCAGGCGACAGATATTCGCGAACCAGGTCTTCGAGTCCCTGGCGGCCAGGCCGCAGAGTGCCGTACCTCGCGACCTGTGTGCGCAGTTGGTCGGCCATGACATGGGCGACGAGATCGTCTTTGGACGCGAAGTGGGCGTAGAAGGCTCCGTTGGTGAGCCCGGCATCCGACATCAGCGTGGAGATGCCCGAGCCGTCGATGCCGTCCTGCTTGAACCGGTGGCCGGCCTTCTCGATGATCCGTTGCCGTGTCACCTGCTTGTGCTCCTTGGCGTAGCGCACCACAAGCTTCCTCCATTCGCTCCGTAAGACCGTTGCCTCGCATCCAAGCCTAATCTATGGGCTGACGCACGTAATATTATGATCGGCAGGCAATTTGCTCGCCCACGCCACCAGTAGCTGCATGCTCTTCCCGGTGCCGCCCTGTCAGGGTGAGGCTCGGCGGCGACCGGTGAATCGGACCTGACCCCCCGATGCACCGATGTCTCATCCCTCCCCCCATCTCATCCCTCCTCGCTGTTGAACGGCGGTGGTTGATGTCTGTGCGGTGATGCCGGCCTCCTTCGTCCTCTGCGCAGAACGCCGGGTACGAGGTGAAGCGGCTGCGGTGCACGTCGGTGGCGCCCCCTGGCTCCTTGGGTCGCCGGGCCGCCGTGCGCCGCAGCCGTGTTGAGGCGCCCGAGGTCGGTTCCCTCGGGCGCCGGGGCCTTCGTCAGGCTTCGTAGGTGGGGTAGTCGGTGTAACCGGCCGCGCCGCCGCCGTAGAAAGTGTTGGGGTCAGGGGTGTTCAGGGGTGCGCCGGCGCGTACGCGCTCGACGAGGTCGGGGTTGGCGAGGGCCATGGTGCCGACGGTGATGACGTCGGCCAGGCCGTCCTCGATGTCCTTGACGCGGGTGGGGATGTCGGCGCCGGCCCGGTTGAGGAACAGCGTCGTCGGCCACAGCTTGCGGAGGGTGAAGAGGAGTTCCTCGTCGCCCCCGTGCCCTACGTGCAGGTAGGCGAGGTTGAGCGGGGCGAGGGCGCGCAGGAGGTGCGGGTAGAGCTCGTGCGGGTCGCTCTCCACGAGGTCGTTGAGCTGGAAGGGGTTGCCGGGAGAGATCCGGATGCCGGTGCGTCCGGCGCCGATCTCGTCGGCCACGGCCGTGGCGACCTCCACCGCGAAACGGATGCGGTTGTCGAGGGAACCCCCGTACTGGTCGGTGCGCTGGTTGGCGCTGGGGAAGAGGAACTGGTTGACCAGGTAGCCGTTGGCCCCGTGGATCTCGACGCCGTCGGCGCCGGCCGCGATGGCCGCGGCGGCGGCGCGCCGGAAGTCGTCGACCGTCGCGGCGACCTCCTCGGTGGACAGCTCACGCGGCTCCGGCATCTCCTGGAGTCCGGACACGGTGAACGTCTGTCCCGCCGGCTTGATCGCGGAGGGAGCCACCGGCTGCCGGCGGTGGGGCGTGTTGTCCGGGTGGGCGATACGCCCGGCGTGCATCAGCTGGATGACGATGCGCCCGTCGGCCCCGTGTACGGCGTCGGCGACCTTGCGCCATCCGGCGATGTGTTCCTCGGTGTAGATGCCCGGGGTCACCGGGTAGCCCTGGCCGTCGGCGGAGGGCTGGGTGCCCTCGGTGATGATGAGCGCGTGCGAGGCGCGCTGGGCGTAGTACTCGGCGTTCAGCTCGGTCGGTACGCCGTCCGGGGTGGCCCGGCTGCGGGTCAGGGGGGCCATGGCGAGCCGGTGCGGCAGCGTGATCTCTCCGGCGACGGTCGGGTTCCACAGGGCGTTGGACATGGGTAATTCCTCAGATGATGGGTGGTGGATTACTGAGAGGCAGAGGCGGGCACCGTGTGGGAGTGGTCGACGGGGGTACCGGGTTTTCCTGCTTCCGAGCCCGGTAACGCACCCGTCATGACCCCTACCGGCCGAGCCGCTGTCGGCGCGATCCATAGAATTACATCCATAATGCTATGCATCGGGGTGGGCGGTCACAAGTGGGGTCCCTGGGGTGGCGGTGATGGCCGGTGCGGGCCCGGGCCGCACCGCAGGCCACAAACGAAAGCCTCCCGTAATACCAGGACAGTCCGGGGCAGGCAGCAGCCTGCTCCGATGTGAACCGACACCCCACCTGGCGGCACCGTGACTTCTAGGGGGCAACGCCCGCTCAAGCCATCGCCGTCGACATCCCCTGTCTCAAGAAGATCCACACTGGCAGCGATGTGTCCGGGCAACACCACTGGCGCCAGTTCGGCGACGACCTCGTACTTCCACACCTCGGGAAGCTCGCGGCGCAAGTGCTGCCGCACCAGGTCGACCAATTTGATCTCGCTCGGGGTGCGAGGCCCCGAGCGAGATCACTGAGGAAGACATGGGCGTCGGTTCCCACCGCTCGCCCTCGGCCAGGCCGCGAGTCAGCCGTTCACGGGGTGTGACCGGCGCGGCGGAGAACAGGGCGCAGGACCTCGATGACGCCGGGGTCGTCCACTGTGGAGGGGATGGGCTCGTCGTGGCCGTCGGCGATACCGCGCATCGTCTTGCGCAGGATCTTTCCCGAGCGGGTCTTGGGCAGGGCGGCTACGACCGAGACATCCTTGAGAGAGGCGACGGCGCCGATGCGCTCGCGTACGAGCTGGACGAGTTCGGCCTCGACCTCGCTCGGTTCGCGGTCGATGCCGGCTTTCAGAACGACGAAGCCGCGCGGTACCTGTCCCTTCAGGGCGTCGGCGACGCCGATGACGGCGCATTCGGCGACGTCGGGGTGGGCGGCCAGGGCCTCTTCCATGCTGCCGGTGGACAGGCGGTGTCCGGCGACGTTGATGACGTCGTCGGTGCGGCCCATGACGAAGACGTAGCCGTCGTCGTCGATGTGGCCGCTGTCGCCGGTGAGGTAATAGCCGGCGTAGGCGGAGAGGTAGGAGGCGACGTAGCGGTCGTCGTCCTTCCAAAGAGTGGGGAGTGCGCCGGGTGGCAGGGGGAGCTTGACGACGATCGCACCGTCGACGCCCGCGGGCGCCGGCTCGCCCGAAGGGTCGAGGACGCGGACGTCCCAGCCCGGCAGCGGGAGGGTGGGGGACCCGGGCTTGAGGGGAGCCGCCTCGATGCCCACTGGGTTGGCGACGATGGGCCAGCCGGTCTCGGTCTGCCACCAGTGGTCGATCACCGGGATGCCCAGAAGATCGCTCGCCCAGTGATAGGTCTCGGGGTCGAGGCGCTCGCCGGCGAGGAAGAGGTGGCGCAGGCCGGTCAGGTCGTAGCCGGCGGTGAGCGTTCCCTGCGGGTCCTCCTTGCGGATGGCCCGGAATGCGGTAGGTGCCGTGAACATGGTCTTGACCCCGTACTCGGCGGCAACACGCCAGAACTGGCCCGCGTCCGGGGTACCCACCGGCTTGCCTTCGTACAGGACTGTCGTGGCGCCGACCAGCAACGGCGCGTAGACGATGTACGAGTGCCCCACGACCCAGCCGACATCGGAGCCGGTGAACATCGTCTCGCCCGGGCCCACGTCGTAGACGGCTCCCATCGACCAGTGGAGGGCGACCGCGTAGCCGCCGCAGTCACGCACAACTCCCTTGGGTTTTCCGGTCGTTCCGGAGGTGTAGAGGATGTAGAGGGGATCCGTGGCGGGGACGGGAACGCAGTCGGTCGGCGGTGCGGCGGCGACCAGGTCGCCCCAGTCGAGATCGTCCGGCCCCAACTCGGCCAGGTTCTGCGGGCGTTGCAGGATCACACTCTTTTCCGGCCTGTGAGCCGCGAGTTCGATCGCCCGGTCGAGCAGGGGCTTGTACGCGAGAACACGCTTGCCCTCGATGCCGCACGAGGCGGAGACGACCACCTTGGGAGCCGCGTCGTCGATGCGGAGGGCGAGTTCGCGCGGGGCGAACCCGCCGAAGACGACCGAGTGCACCGCGCCGATACGTGCGCACGCCAGCATCGCGATCACGGCCTCTGGGACCATCGGCATGTAGATGACCACACGATCGCCGTGCCCCACGCCGAGCTGCGCGAGTGCTCCGGCGAAGGCCGCCACCTCGTTCCTCAGCTGCGCGTAGGTGTAGGTGCGCCTGGTGCCGGTCACGGGTGAGTCATAGATGAGCGCGCGCTGTTCGCCGCGGCCGGCTTCGACATGCCGGTCGACCGCGTTGAAACAGACGTTGAGCCGCCCGTCGGGAAACCAGCGGTAGAAGGGTGCGCCCGAGGAGTCCAGGGCGCGTTGCGGGGTGACATCCCAGTCGATGCCCTCGGCCGCCTTCAGCCAGAAGCTCTCCGAGTCTTCGGTACTGGCGCGGAAGACATCCTCGTACGTTCCCATCGCGCACTCCTTTGTGGCATCGAGGGGCAGGCGTGTGGCGGGGTGCAGAACGGTGCCGGACACAAGTACCGCATGTAGGCCGACATGGTCGAGCAGGATGCCGGAGACCAGCGGCCTGGTCACCGGCATCGCGGTGGTGCAGCAGGCCCCGCCTTCAGATTTTGGTTCCGCTCACGCGCCGAGATGCCGACGGAGCCACTGGCCCATCTGCTGGATGGCCTGGTCGACCTCGGGTACGCGTCCCGCGCCCAGGACGAACGAATGCTGTCCTTCGGGCAGAGGGTGTACCTGGGAGGTGACGTTGAAGTCCGCGAGTCGGAGGCCGAGCTGGGCGCCGTCGTCGGCGAGGGTCTCGTACTCGCCGTAGTGGACGATCGTGGGCGGCAGGCCGGTCAGATCGGCGTTCACGAGGCTGATCTGCGGGTCGGCGAAGTCCACTCCGGGCTCCTGCAGCCAGGCTCCTCGGAACAGCTCGAGCGTGTTCCTGCTGAGCATCTTGTCGTTCTCTTCGTTCTTGTCGACCGCGGCGTTCTGCAGGGTGAGGTCGGTCCACGGGGAGACGCTGGCGATCGCGCCTGGGGTCGCCTCGCCCTTGGCGAGCAGGCGCAGCGGCAGCATCACGGCAAGGGTGCCGCCGATCGAGTGGCCCGTGCTGCCGATGTTCCGCGGCTCGTAGCCCTGGGAGAGCAGCCATCGGTAGGCGGTCTCGGCATCGTCGAGCTGTGCAGGGTGGGGGTGTTCGGGTGCCAGGCGGAAGTTGACGACGAGGGAGCGGGCGCCGGCCGCCTTGGCAATATGGCCGGCGGCCTTGCGGTCCGAGTGCATGGAGGCGGTGACCGACCCGCCGAAGTGGAAGTGGAGGAGTGCACGGTCGGGGTGGGCGTCTTCGGGGATGCACCAGAGGGCGGGGACGCCGTCTGTGTCGACTTCGGCGTAGGTGACACCTTCCGGTTCGGCCGAGGCCCGGTGGTTCGTCTCGACGATGTCGCGGATGACGGCCAGGTCGAGGCCTGGTGTCGACGACCTCGCGCTCACGCTCTCGAGGAACTGCGCGAACTGCTGTGCCTCTGGGCTTGCTCCCATGGTGGCGCTCCTTCACGGGTCGGTGCCGGTCCGCTTCTTGTGTACGGCCGGGTGGATGTGCTGGTCATGACGCTACTCGCTGAGTATATGAAAGTAAACTCAGGTTAGGTTGGAATCACTTCATGGATGCGTGGAGGCGGATTCTTCTTTGGCGGTTCGCTGTTCGACCACGTCAGCCCGGACATGCGGATCTACCGCGAGGAGATCTTCGGCCCGGTGCTCGCCATGGTTCGGGCGCAGTCGTTCACCGAGGCCTTGCAGTTGGTCAACGACCACGAGTTCGGCGGGATCGGGTTCCTTCCGGATGCCTGGGCCAGTTTCTTTCTGTCGAGGCTGCCCGGTGCGATCGGCATGCACCCGGGACTGGCCGGGCCCCGCTTGACGCGGCCGACGCCCTGTATGCGGGACTGGCCACGCACTTCGTCCCCGCGGACAGGCTCGACGCGGTCGGGGATGCCCTTGCCGACAACCCCGGCGACCCCGTGGACGTCGCCCTCAACCCCTGGAGGGCGTCCGTGCGGCTCTGGTCGACAAGGACCGCAGCCCCACCTGGCAACGTGCGTCGCGCGGCGGACGAACGCTGCTGGCCTGAGCATTTCCGCCATGCGCAGGACATCGCCGTCCCCCGGTACTCATGCCTGAGCGAAGACTCTCTTCAACGGATGGTCATCGCGGATCAGGTGCGAGAGGAAGCTGACCGGAGCGAGGCGGACCCTGCCGAACTCGGCGCGTTATTCGATCAACCATGACGTATAGGGCCGTTCGTGCAGGAGGGGCACACGACCACGAGATACGTGGGAGCGTCGAGCTCCGCAGACTGCCGCGGCAGACGTTGGGCGGGGACCGGGAGGACGCTGAGCGCCCTCATGCGTACCGCGGCGAATCCTCGGGAGCCATGCGGGCGGCGTTGCCGCCCATGACAGCCGGCACGCCGTCGGTGTAAGCCTGTCTGGTTGCGTCCGTGCAGCGTCCGATCTCGTCGAGCATGGCCGCGGAAGAGCGACCGTCGCTTGGTGCCGCTGGTCGGCGACCACGGAGGCGGCGAGATCGTCCTCGGACTCTAAGCGGGAGTAGCGGGCGCCGTTGGTCAGCGCCGTGTCACGTCATGAGCGTCGAGCCCTGCGAGCTGTCGATACTGTCTCGCCCGACGCGGCGAGGGTGGTCTCGCCACTGACCGTCTCGTCGCCGGCTTGCGCTCTCCCGGCCGGCCGCGCGGCGAAATCCCCGTCTGTCCACAGTCCGTCCGTCCGATTGTGTGCCCGTGTCGTCGTCGTGCCACGGGGGTAGCTTGCCTGCACGACCTGCGCGGGCAGGGGCGGTACCGGTGCATTGTGGCACGGGAGGACGGACACTGGGCTCACCTCAGGGGCAACTTCGATCTGGGCGGGCCCACGCAGGGGTGGTGGCTCGGCGGCTGTGATCAACCCCGACGCGCAACGGATGTAGGGCCTTGACCATGGCTCAGGTTGACGTTGAGCCGCGTGGCGCGCTGTGCCGCGAGCGTATGACGTCACGGATGGCACCGAGATGCCTACAGCAGCGACCCTCCGTGAAAGTGGTCGCCATAGGATCGCCGACGGCGTCGTCGCCTCCTTCGGTGACCGCGCCGGGCGGAAGGCCTGCGGCCGGCCTGATCTCAGTCGCTGTCGGGCACCATCGAGACCACGACCTTGCCGGCCTTGGTGCGCCCCTGCTCGACGTACGCCATCGCCTCGAGGGTCTGGTCGAACGGGAACGTCCTGTCGATGACCGGGCGGAGCTTCCCGCTGTCGTAGAGGGCGCTCAGCTTGCGCAGCTGGGAGCCGTTGGCCTGCATGAAGAAGAACTGGTAGCGCACGCTCAGCGTCTTGGCCTGCTTGCGGATCTTGCGGCTGAGCGTGTTCATGACGGTACCCATGAACGAGGGGGCGCCGATCTGCTTGGCGAACCCGGCGTCCGGCGGGCCGACGACACCGACGGCCAGGCCGCCGGGCTTCAGCACCGTCAGAGACTTCTCGAGGTTCGCCCCGCCCAGGGAGTCCAGCACCAGGTCGTAGCCGGACAACACCTTCGAGAAGTCTTCCTTGGTGTAGTCGACGACGACATCGGCGCCCAGGCTCCTGACCAACTTCTCGGTGTCGGTGTCCGTCGTCGTCGCTACCGTGGCGCCGAGGTGCTTGGCGAGCTGGATGACCGTCGACCCGAGGCCACCGGCACCGGCGTGGATGAGCACCTTCTGACCCGGCTTCACGCGGGCACGGTCGACGAGGATCTGCCAGGCGGCCAAGGCCACCAGCGGCACCGCGGCTGCCTCTTGGAGGTTGAGCGAGGCCGGCTTGGGCGCGACATCGTCCTGGTCGATCGAGATGAACTCCGCGAAGCCTCCGATCCGCAGGTCCCGCGGACGGGCGTAGACCTCGTCGCCGACTTTGAAGCCGTATACCGCGGAGCCGACCCGCGTCACGACGCCGGCCACGTCGTGGCCGAGTGCAAACGGAAGCTTGTACTTCAGGAGCTGCTTGAATTCCCCGTTGCGGACCATTTTGTCCAGCGGGTTGATGCTGGCCGCGCTCACTCTGACCAGGACGTCGCGGTCCCCGACGGTGGGCTCAGGTACCTCTGCGGCGCGCGCGCCGTCCTTGCCGTACTTCTCGACGACGAAGGCCTTCATGTCAGCCGCCCTTCTGTGTGATCTTCTCGGTGGTTTTCTTGGTGGTCGATGTGGTTGTTCAGGCAGTTCTTCTACTCAGGTGCCGAGGTGCTGGCGGAGCCACTGGCTCATTTGCTGGATGGCCGGGTCAGCCTCGGGTATGCGTCCCGCGCCCAGGGTGAAGGAATGCTCTCCTTCGAGCGGCGGGTGGACCTGGGGGCGACGTTGACGTCCGCGAGGCCCGCTTCGCGTGTGCGGCCGGGTCGATGTACGGTCATGACGTTACTGGCTGAGTATGGAAAAGTAAACTCAGATAAGGTTAGAATCACCCACATGGATGCGTGGACCGAAGCACTTCAGGACGCCGGCATGGACCCCCGTCTCGACCGGGACGTGTCGAACTGCTCGATCGCGCGGACCCTTGAGGTCGTGGGTGAGAAGTGGACGATCCTGATCCTCCGCGAGGTCTGGTACGGCTCGTCCCGCTTCAGTGACTTCGAACGCGTCCTCGGCTGTCCTCGCAACCTTCTCGCGACACGGCTCCGGATGCTCGTGGAGGAAGGGATCCTGGCCACCGAGACCTACAAGGAGCCTGGCTCGCGGAGTCGGCCGAAGTACGTGATCACCCCCAAGGGTATGGATCTGGTCCCAGCCGTGATGGGGCTCCTGCAGTGGGGCGACCGATACCGCGCCGACCCGGAGGGGCCCGCTGTACTGGCGCGACACCGCGCATGCGGCGCGCACGTCGACGTCCAGGTGCGCTGCGAACGAGGCCACTCCGTGCAGGCGGAAGACATCGAGAGTGTCCCCGGCCCTGCATTTCGTATGAAGCCCGCCGAGTGAGCTGAGCGCGGTTGCGTCAGGCGATCGGCGCGAAATCCTCACCGGCCGCACGCGAAGGCGGCGCCCCTCCCGGCCGGGAGGGGCGCCGCCTTCGCGGCAAGAAGTACTACGTGGTTTCAGCCTTCCGGGGGGCCTCACTCTGTCTGGCTCGGGCCTGGTGGAGGCGGACCCTGGCGCGCTTGCCGCAGCGGGACATGGAGCACCAGCGGCGGTTGTGGGCGGGGGAGCGGTCCAGGAAGCGCAGGGCGCGCGTGTCCGCGCCGCAGATGCGTGCGCGCCGGGTCTCGGCGGACAGGAGCAGATCGACGGCGTCCTGGGCGACGAGTGCCGACGCGGCCGTGGGGTCGGCGGCGAGGCTCGTGGTGCCGGCGGGCTCCGGGCGTCCGTCCGTGACGGCGATTTGCAGGGCCGTCCGGGGGCCTCCGCTGCCGATCGGTTGAGCAGCTTGACGTCGGCGGATGAGGCAGCCGACCGTCGGCGACCGCGAGCACGGCCCGGTCGACCGCCTCGCGCAGCCGTCGGCCCGACGCCAGGACGGCGGCATCGGCGGGGTCCGGGGCGCCCGGCGTGAGCAGACCGGCCTCCTGAAGCCAGAGGATCAGTTCGCCCGAATTCCGGAGCGTCTCCTCAGGCGTGGTCCGCCACCGGCTGCGGAGGGTGTTGATGAGGTCCAGGCAGGCCCGCCCGCCGTCCCACATCCACATATCGTCCGTTGCCACGCCTCCGTTCTGCACGCTAGCTTAACCCTCTAAGAGGGTTAGTCCGTGCCAAGGAGGCGCATCCATGGGACGGCCACCAGTAACCACCGGAGTGACGCAGGTGGACGGGGTCCGCCTGCACTACGTCCGAGCGGGATCCGGCCCTCTGCTCGTTCTGCTCCACGGCTGGCCGCAGACCTCCGACTGCTGGCGGCCGGTGCTGGCGGATCTCGCCGCCGACCACACCGTTGTGGCACCCGACCTGTGTGGCTACGGCCTGAGCGATAAGCCCGCGACCGGTTACGACAAGCGGCGGATGGCCGCCGACATGGCTGGCCTCGTCGAGGCACTCGGCTTCGAAAAGGCCGTGGTTGTGGGTCACGACCGCGGCGCCCGCGTGGCGCACCGCTGGGCGCTGGACCGCCCTGAGCAGGTGGAGCGGCTGGCTGTGCTCGACGTGGTGCCCACCCGGGAGATGTTCCGCCGCATGGACGCCTCACTCGCTTCCGGGTACTGGCGCTGGCTGTTCCAGATGCAACCCGATCTGCCCGAGCGTCTCGTGGGGCATGGCTTTGTTCACGAGTCGTGACGTCAGTTGTTCACGAGTTTGGGAGGCACCCCGATCCACCGTCGGGTGATGTTCGCGAGTTTTGACAGCACCGGGCTACTTGCCAGGGCAGCATCGAGATGCTCCTGGTGAAAGGCCCTGGTCATGCCGCAGATGTCGAAGGTCACCGCCAGCTGACCTTTCCAGTCGTTCCGCATGCCCCGCTTGGAGACGGGCTACCGCGATGACCAGGGAACACGCTTCTGCTGGCCGACCGGGCGGACATCGACAAGATCGAAGCCACCCTCGTGGCGCACGAGATGTCGGACCTGGCCCAGGCCGGAGTCACGGACGAACCCGACCCACCCTTGCGTCGTCGCGTGTCGAAGAAGCCACCCGACGACGTCCATCGTCACCCCGAAGTCGTCCTCGTGGACGCACGCCCGGACGGTCAGGGCCCACGGTTCGCTGCCGTCCAGGTTCGGCCTGTCCATGGCACGGACCAGCAGGGAGACATCGGCCCCGTCGAACGAGTGGCTCGCCGAGCCACCGTCGAAGGCCTGCCAGGGACCGCCCCATGACTCCCAGTCGGTCGACTTCAACTCTGTCGGCATGTCCGCCTGCCCCAGGAGCCACCTCAGTTCCAAAAGCACCGGCTCGGGCAGGTCCGGCGGCAGGTCCACCGCCAGGAACAGGTCGTAGTAGTCACTCACACCAGGGACCCTAGCCCCAGCCGCTGACAGCACTCTGCGGGCCTGTCAGACCTCGACGGAGCCCAGTGCTGTCAAAACTCGTGAACATCAGTCGGCGGCTTGACCACCAAGCGCTGCCCAAACTCATCGACAAACGCTGTCCTAAGAAGTGAACGAAGCCACGTGGGGCACGACATCCGTGGGTATCTTGAGTACTTCTTCGAGCGCTGGACCTACAACCGCCACGGGCTGACACCCGAAGCGGTCGACGGCTATGTCCGTGCGTTCTCCCGCCCGGGTGCCATGCGCGCAAGCTTCGACGACTACCGGGCCATGGAGCAGGACATCGCGCTCGACGACATCGACGCCGCCGAAGGCCGCCGCCTCACCATGCCGGTGCTGGCAGTGTGGGGTTCCGCAGGACTCCCGGCCCGCCTGCTCACGCTGGAGATCTGGCGTGCCTACGCGGACGATGTCACCGGTGCCGAGATCCCGGAATGCGGCCACTTCATCCCGGAGGAGCAGCCGGAGGCGCTGCTGGTGCATCTACGGGCCTTCTTGGCCGGCGGGACGAACCAATGGCCCCGACACGGTGACGGAATCGGCGCCCCTCCGGTCATGCGAGCGCTGGCGGACCAGTCGAGCCGTCCGACGGGCCTCGACCACGGTGTGATGTCACCGTATGGCTAATGAGCCTGGAAGGCAGGACAGGCCGAGGGGGCGGGCCCAACCACACCGGCCTGGGCCGCCCCTCGGAACGGGCCTCAGGTCGCGACCGGGACGCCGGCCGGAGCATCCCCCGCGGCAAGGCCGGCAGCCGGGCTATCGGCCTTGCGCTGCCGGGGCATCAGCAACGCCAGGGCCGCCGCCAGGGCGACCGCACCGGCCCCGACCCAGAGCGCCGGGACCAGCCCGTCCACGAACAGCGAGGCGGACCCGTAGCCGCCCTGGGCGGAGAAGACCGCTGCCAGCGACGCGACGCCGATGGCGCCGCCGACCTCGCGGATCGCGTTGTTGGCGCCGGAGGCGATGCCCTGCTCCTCCGGGCGGACCGTGCTCATGACGAGGTTCGCGCTGGGGGCGAAGAACATGCCCATGCCGGTTCCGCAGACGATCAGCGCCGGCAGCAGAGAGGTGTACGACACCTGCGGCTCGACGGCCAGCGCCCAGAGCGCGAGGCCCACCGCGTTCAGGGCCATGCCTGCCGTGACGACAGGACCGCCGCCGACGCGGTCGGACAGCGCCCCGGCCAGCGGTCCGGCGAACATGGGCATGGCGGTCCAGGGCAGCATCCGCACGCCGGCTTCCATTGGTGAGTAGCCGCCGACGGTCTGCAGGTACTGGCTGAGCAGGAAGATTGACCCGAACATCCCCAGGAACATCAGCAGGCTGGCGGCGTTGATGGCGCTGAAGGAGCGCTGGCGGAAGGTACGCATCGGCAGCATCGGGTGCTTGGCGCGCAGTTCGTAGAGGACGAAGCTGACGAGCAGGGCCGTACCCGCGAAGAAGCCGCCGAGCACCGGGGTGCTGGTCCAGCCGTTGGTATTGCCGCGCACCAGGGCGTAGACGATGCCGAACAGACCGCCGCTGACGAGGGCCGTGCCGACGAGGTCGAGGCTCGGGTTCGGGCCGTGGCTCTCGCCCAGCCGCAGCAGGGCCAGCGGAATCAGCGCCAGGCCGAGCGGGACGTTCACCCAGAAGATCCACTGCCAGGAGAGATGTTCGGTGAGCGTGCCGCCGATGAGCGGTCCGGTGGCGACGGCGATGCCGCTGGCCGCGCCCCAGATACCGAAGGCCACGCCGCGCCGTTCGGCGGGGACGGCCGCCGCCAGCAGGGTGAGGGTCAGCGGCGTCACGATCGCGGCCCCGACGCCCTGCGCCGCACGGGCGGCGATCAGTTCACCCATCCCGGGGGCGAGTGCGGCCGCGGCCGAGGCTGCGGGTGAAGATCGTGAGCCCAATAGCGAACAGTCTTCGGCGGCCGAAGCGGTCGCCGAGGGAAGCGCCGAACATGAGCAGGACCGCGAAGGTGAGGGTGTAGGCGCTCACCGTCCATTCGAGGTCTTCGAGGCCGCCGCCGAGGTCCTCGCGGATGGAGGGGAGGGCGGTGGTGACGATCAGGTTGTCGAGCGCGGTGATGAATCCGGCCATGCTGGTGATGACCACGGCCCAGACGGCGCTGCCGCGCCGAGCCGGTTGCTTGCGGTGCTGTGTCATGACGTTCCCTCGGCAGACGTGCCTGGCGATTGACCAATGGGTGTGGATGCCGGTGCTCGGCGTGCGGCACCGAGCACCGGTACGTACGGCTTGTGCGGATTCCTGGGCGGCTGCCCCTCAGGGGAGCTGCGGGTAGAGCACGGAGACGCCCCCGGACAGCGCGGCCTGCGCCTGGCGGGCGGCGTTGTCCGCGAGGATCTCGTAGGCGCCGGCGGCGATGCCGTCGACTGCGATCCGGGCGATGTCGGCGGGGTCGGACTTGGCTGCGTCGACTGCCCGGACCATGTCGGTGTCCATGTAGCCGACGTGCAGTCCGGCCACTTGGATGCCCTGGTCGGCGAGCTGCACGCGCAGGGCATTGGTGAGCGACCACTCCGCGGACTTGGCGGCGCAGTAGGCGCCGATCTCCGGGAAGCTGACCCAGGAGAGGCCGGACAGGACGTTCAGGATCGCCCCGCCGCCGTTGGCTGCGATCTGCGGCGCGAAGCTCCGGGCCATCGAGAGGGTCCCGAAGTAGTGGGTGTCCATCTCCAGTCGGATGTCGTCCAGGTTGGCTTCGAGCAGGTCGGAGCCGGTGGCCGACCCCGCGTTGTTGATCAGGACGGTCACATCGCCTGTGGCCTCGGCGGCGGCCGCGACGGAGGCTGGGTCGGTGATGTCGAGCGGGATCGGCTTGGCACCGGGCAGGTCGACCTGGCCGGGATTGCGGGCGCCGGCGTAGACGGTGGCGCCGCGGCCGAGCAGTTCGGCGGCGAGGGCCCGGCCGAAGCCCCGGTTGGCTCCGGTGACAAGGGCGGTGCTGGTGGAGAGGTTCATGGAGAGTTCCTGGTGAAGTAGGAAAAGCGTGCTCATCGGATCGACTGCGCCGGTGGTGTTCCCGGTCAGCCGCAGGTCAGGCGGTCGGGCCGGTTTGGTGACCGTCGGGTGCGGGTCGGGCGGTGGGGCAGGGGTGAACTCGAAGGGAGACCAGGCGCTGGTGGTGTGGCCTGACCAGGAGAGCTGTCGGCCGAGTCGTCGGCAGTGAGGACTCAAGGTCGTTAAATTACGACCGTAATGCTAAGTGGCGTGAGTCGGTGATCGCAAGCGCGCTGCGCGGAGAGGGGTGCTGTGCCTGCGAGGCTGGCGGTATGCCGGAGGTGCGCTGCCGGACCTGCTGTCGCGGGGCGCGGTCGTAGAGCGGTTACTCCGCCTCCGGGTGTCGTTGAGGCCGGGCCCCCGCGCCGCCCTGGTGCTTCTGGAGCGACCAACGCGCGGGGGGCCCCCCGCCGCTCGCGCGGCAGGCCCCCGCATAGTTGGCTGAGGCAGGCTCAGCTTGTGATTTAACGTCTGCTTCGATGCTCGGCCAGCTGGGTGGTGCGATGCGTCGGCGCGTCGTCACTCTTGGGCGGTCACCCCGAGATCATGGCGCATCGCGGCCCTCATGGCCCGGAGCATGTCCCAGATCTCTGCCTGGGCCTGGATAGCAGTGGCCACCGTCTCCCCAGGTTCGGGCTCTTGTCGCTCAAGGCGTTTTACCTGGCCATAGACCTTGTTCAGGGCCTGATTGACTTCACTCGCGCGTGCGAGCACCTCGTCGGGGGCGATCATCTGCGCTTCGGAGTATCTGTCGCGATGGGCTCCTTTTGCCTCATCGAGTGCCTCGCTGTCGGTCTGCTCGACACTGCGTGCTCGCATGACGTGCAGATGGCGGTTGAGCGCTGTGGTGAACTGGCGTGCATCCCGGTTGAGTTCCATGTAGCAAGTGCGTCGGAGGAGCAGGTTCTCGCGGACTTCCTCTTGGTCCCGAAGCAGCTCTATCTCGCGACGTTTTGCCCGTTCGGAGGCGCGTTGGGTGAGGAACGATCCCCCCAATGTTCCGGCCACACCTGCCACCGCGATGATCACAGAGCCAAGATCCACAGACCCCCCTCGAAGCCGCTTGCAGTCGTATCACCTACTGCTCGCTGCCTCACTGTCAAGCACCAGACCGCTGGTGCGTCGGGGTTTGGTGCCCTTCTTGTGGTGGGCGGGACGGCTGTAGACCTCGCCGGTGGCGAGGACGCGACCCACGTCGTGACGGGTGGCCGGGCGGTGGTTCTTCGAGCCCCGTGGCCTTCCAGGCCCGGGCCGAGAGGGTTTCGGCGCACCGGCCGGAGAGCCGGCCTTCGTCCACAGGTTCCGGAACCCCCGGCGGACCCGAGCGGGCGTGAGCTTGTTCGGCTCGGTCACCTTCTCTCAGGGCCGCCGTAGGTCGACGGCGAGCGGACGGGCGAGCCGGAGCTGGGTGTGCACGACGATCAACCAATGCCGCGAAGTTAGGGGCCTGGAGCCGGTGTCAAGGTGTCGGGGAGCGTGATCTTGTAGGTGTTCGGCGCGGTGCGGGTTAGCCGGCTGTGGCGGGTCCAGAGGCAGAGTTGAGAAGCGAGGTTCTTGCGGGATTGGGGTGCCGTAAGCCCCATGTGGTCGGCGAGGTCGTGGGCGTGCATGGGTTGGTTGGCGTGCGCGGCAAGGATCTGGCAGAGCCGGTCCCAGGGGCTGGATGCCTTGCGGTCCGGATCCTGTGCGGTCGGGAGGACGGGTGCCTGGACCGTGATGTCGATGGCAGCGATGGGGGTGCTGCCGCGGGGACGTTGATCGCGGTTCCAGGTGTGGTAACGCGAGATTCCGCGCTTCGCGACGCGGGCGGAGGTCCGCGGGCGGCGTTTGGGGAGTAAGGCGTGCAGGAGACGGGTGCCGATGTGTCCGACCAGGTCCGCCTGGGCGTCGTGTCCGGGGATCGCTGTCGGGTGGGCGGTGAGGGCGATGGTGTCGCGGGCGGCCTCCAGGGCGATGATGAAGGCGGCGCGGTCCGGGTCGGTGCCAGGCTGGGTCTCCACGGCCGTGACCATGACGGATCGCAATGCCTGGTAGAGGGTGAGCAGTCCCCATAATTCCTGGGTGAGTCCGGCAGGATCCTTCGAGCGCAGGACGCGGCCCTTGAGGAGTGTGTGACGCAGTGCCAGGTAGGCGCACTCGATCTCCCAGCGCTCGTGGTACAGGCGGACGAGCTGGTGGGCGGGGTCGGTGCGGTGGTCGGTGAGCGTGGTCAGCAGCCGGTAGGTCTCGCCGAAGGTGCTGCCGTCGACGGTGCGGGTGCGGATCTCGGCTTCGATGACGCGCAGGGTGAGGCCAGCGATGCGTGTGAGGTAGGAGCCGTCGGGCAGTAGCGTCAGGGTCGGCGGATGCCGACGACTGGTGCAACGCACCAGGAATTGTGCGCCGCGGCGGGCGGCCTGTGCGAGCAGGTCATTGGTGTGGAAGGCTCGGTCAGCCAGTAGCAGCATGTCCGGGGTCAAGTTCGAAGTCAGCTGCTGTGCGTAATACGTCTCGCCTCTGGCCACGGGGCCGAAGGCTGCCGCGATCAGGCCGCGGGTTCCGGTCTCGCACAGTGTCATCAGCATCAGTCTGGGATATCCCGCCTGGCCGAGCCGGCTGGCGGGGCGGCCGAGCCAGGACCAGTTCCGTTCGTGGTCGGGGACGATCAGGCTGCTGCACCCGTCAAAGGCGACCGTCCGCCAGCGTCGGTAACTCACCCCAGGAGTGGACGGCTGGGCCAGCGGCCCCGCCAACACCTCGAAGAGCCGCTTGACCGGAGCCGGGCCGATCCTGCGGCGCAGGTCACGAAGCGCCTTCTCGGAAGGCTCGGGGACGCGGGCGGTCAGCCCCGCGGCCAGCTTGGTCCACACGAGTCGGGCGCCGAGATGCTCGAACAATCCCAAAGCCAGAACGAAGTACACGCCGACCCGGGAGGGAAGACATCGCAGCCGTCGCTCCCGCGCTCCGGTCTCCTCCAGAACCGCGTCAATCAACTCCGGGGGCACGACCTGCGTTAACTCACCGAGATGGCCGGGGGCGAACACATCGCTGGTGCCGCCCATGACAGACTGGACCACAGGGCCTCTGCTTTCGGGAAGATCTTGGTCGATCCCCTGGATAGCAGAGGCCCCGCCGCATTTCACACCCTCTTGACACCGGCTCCAGGCCCCTAACTTCGCGGCATTGGACGATCAACAGCCAGGTCCAGCGATCGGCCGCCTGCGAGCTCCGCAACCGCGGCTTCGTCCAGCCCAGCGTCTGCTTGAACAGGCGAAATGTGTGCTCGACATCGAAACGCCGAAGGAAGGACTGCCAGCAGCGGTCGACATCGGCCATGGTGGCGTCCGTGCCTGACCACCACAGCCTCTCCCCGGCCACGGTCACCCGGCTGACCGCGCAGTGGCAGGCAGACCACGCCGCCTTCCAGGACCGCGACTTGTCCCGGACCGACTACGTCTACATTTGGGTTGATGGCATCCACCTACGGATACGCCTGGACCAGGCCAAGGCCGCCGTCCTGGTCGTGCTCGGCGTGCGCGCCGATGGCATCAAGGAACTGGTGGCCATGACAGACGGCTATCGGGAATCGTCCGAGGCGTGGGCTGGCCTGTTGCGAGACTGCGCACGCCGGGGCATGCGCGCCCCGGTCCTGGCCGTCGGCGACGGCGCGCTCGGGTTCTGGAAGGCCCTGCGCGAGGTCTTCCCCGCCACCCGCGAACAGCGGTGCTGGGTTCACAAGACCGTCAACGTGATCGACTCCATGCCCAAGTCCGCGCAGCCCGCAGCGAAGAAGGCCCTGCAAGACATCTACAACGCCGAGGACCGTGAACACGCCGAGCAGGCGATCCGGGCGTTCGCCAAGCTCTACCAAGCAAAGTTCCCCAAAGCTGTGGCGAAGGTCACCGACGACCAGGACGTGCTGCTGGAGTTCTACGACTATCCCGCCGAGCACTGGATCCATCTGCGGACCACCAACCCCATCGAGTCGACCTTCGCGACCGTGCGGCTCCGGACCAAGGTCACCAAGGGAGCCGGTTCCCGGGCCGCCGGTCTGGCCATGGTCTTCAAGCTGATCGAGTCCGCCCAGGCCCGCTGGCGCGCGGTCAACGGCGCCCACCTCGTTCCGCTCGTCCGCGCCGGGGCTCGCTTCGAACGCGGGCTCCTGGGCGAGCGGCGGGAGGACGCCGCAGCCTGATCACGCCTCACGCGATCCTTTCAGACCGTGATCGCAAGCTTGCCCTGCACGCCGCCAGCAGCCAGCACCTCGTGCGCCTCGGCCAACCTCTCCAGTGGGAAGACCTGCTGCAGGTGCACCCGCATCCTCCCCGCCTCGACCAGCTCGGTCAGTGCCTCCAGGCCGGCCGGGTCCGGCTCCACGCCGACCGCCGCGAAGCGCACGCCGGACTGCTCCGCCAGCTCCGGCAGGGTGGTGCTAAGCCGCTCCACCGCCGTCACCAGCACGCCGCCCTGCCGCAGCACGCCGAAGGAACGCTCGGCGTTCCCTCCCCCCAGGGTCTCCAACACCACGTCCACCGGCGCGTCCCGAAGCACCTCGGTGTAGTCCTGGGTCCGGTAGTCGATCAGCTGGTCCGCACCCAACCCGCGCAGGAAGTCGTGCTTGCCCGCGCTCGCCGTGCCCACCACCTCCGCGCCGAGGTGCTTGGCAAGCTGAACCGCGACGTGCCCGAGCCCGCCGCCCGCGCCGTGGATCAGTGCCCGTTGCCCTGACCGCAGTTGCGCGATCTCCACCAGTGCGTGCCAGGCGGTCAGGCCGACCAGCGGCAGCGCTGCGGCCTCCTCGTGGCCAATTCCTGCGGGCTTGCGCGCCAGCTGCCGCGCGGGGGCGACCAGGTACTCGGCGTTCGCCCCGGCCGCGGCCGGGAAGTACGGCATCCCGTAGACTTCGTCGCCGACCTTGAACCGGTGCACACCCGGGTCGACCTGCTCGACCACCCCGGACATGTCCCAGCCCAGGACGAAGGGCGGCTCGCCCAGCAACGGGAATGCGCCGGAGCGGACGAACAGTTCCACGGGGTTGACGCTGGTCGCCTTGACTCGGACCAGCACCTGCGTCGGTCCAGGTGCTGGCTTGGGGGCGTCGTCGACGAGCTCCAGCACCTCGGGGCCGCCGAAGGTCATCTGGGTGATCGCGCGCATCGTCATGCACTCCTGTTCGGAAAGTCGCTTGGGATGTCCCTATCCTCGGCGGGCCGGTAACCGTTGCACAGAAGGCACTTCAAAGGTATATAGGTACCTCATGGGTACCACTGACGACCTGCGCTTCTACGGCGGCGCGGATGCCTATCTGGCTGCCTGCCCCTCGCGCCAGATCCTGGATGTACTCGCCAACAAGTGGACCATGTTGGTCATGGGTGCACTATCCGGCGGCCCGATGCGCTTTGGCGAGCTGCGGCGCCGACTGGACGGCATCACCCAGAAGATGCTCACCCAGACCCTTCGCACCCTGGAGCGGGACGGCCTGGTCACCCGCACGGTCTTCCCGACCATTCCACCAAAGGTCGAATACGCGGCCACCGGGCTGGGCGAGAGCGTCACCGCGCTGATGCACGCGATCCGCGCCTGGTCGGAGGAGAACATCAATGCAGTCCTGAACGCCCGCGACACCTACGACGCGCGGGCCGCCCAGGAGGTACAGCCAGTCACGACCTGATCGCCTCCGGTTCGGCAGTGCCTGGTCGGCTTCGGACTGGTCATCGAGACCCAGCCCGGCTTGTTCACCCTGCGCCACCAGTAGCCCCACGTCGCAGCTCAGCTCAGAACGCCAAAGTCCAGCGATCCACAACTTTTGACAATTGCTCAACGTTCCCCAAGATCTAGCTCTGTCGCTGATTTGGGGGTTCGTCGGTTGCTCATGGCGAGAGGAGGATGCGTCGCCGCAAGAGGTCGAAGTTGGCCCGGCCGTACATCTGTCTTTTCAGCAGTTTGATTCTCGTGACGTTGCCCTCCACAGGCCCTGAACTGTGGGTGGTGTTGAGAGCTGAGAGGATGGCGGCCTGGTTACGGCGCATGCCACGGCCGAGGGCCTGCAGTTCGTGTGGTCCGTCGAGCCGGACATCGGCGAGCCAGACCTCGAAGGCCAGGTGCTCGTTGCGGTGGTCACGCAGGAGGGCGGCCAGGCGGCGGGCGTACTCGGTGGTCGAGGCCAGGGCGGGGCAGCGTTCGCACAGGTCGGTCAAGAGCTTGCGTTCGGTGTCCGTGAGGTGCTCGGGGCGACGCATGATCCAGTCGGTGACGCGGCGGACGGTCCGCAGGGGCAGCGGGGCTTGTGCCGGGATCGCCCCGGTGCGATAGGGCCGGAGATGACGGCGGACGGTGTTGACGTCACCGCGGTAACCCAGCTGCTGGATTTCACGCGCGAGGGCAGAGGCGTTGGTGCAGCTCTCCAGCCAGCGATGATGCAGGTAGAGACGGTAGTCATCCATCAGGCTGGGGCGGTGGGTGGCCGCAGCGAGGAGTTCTTCGACATCGGCGGTCCGCGCGAACCGGGCCACGGTGCCCCGGCTGAGACCGAGTTCACGGGCGACGGCACGCATGCTGTCGCCCGGTTCCATGCGTTCGTGAATCTGCTGATACCGCTCGCGGGTCCGTGACACCAGCGGACGGGGCCGCCCATGGATGTCGAGTTCACGTTGGGCAGCTGCTGCGGCGGGCGGTGTGCCGACGGGAACCGCGAGAGGCTCGCACGACTGCGCACGGTGCCGTCCGACGATGCGTTCGACTGCCTCGGCGAGATTGTGCATCAGATGCCAGATGTCGGCCACCTGTCTGGCCTGAGGTGCTCCTGCACAGGCTCCGTCGCGGAAGGGCCCGGCCCGATCGCGGCAGATGACCCGCACCTCGGGATGACCGCGCAGCCAGGCCGCGAAGGTTTCGGCCCTCCGGTCGGCAAGAACGTCAACGGGACGACGGGTGGTCATGTTGATCAAGATCGTCGCGTAGGTCCTGCGGCGGCGCAGGGCGAACTCGTCGACGCCGAGGACCGGGACGGGGCCCGGCTCCGGGTCGGGTAGAGCGCGGAGCTGCCGGAGCAGAGTGTCGTTGCAGGTCGTGATGGACATTCGCTTGGACAGTCGGGTTCCCGGGCGGGCACCCAGGAACAGCGCCACGTCGGTGAGCAGGGTGGTGAGGGACTGCGTCCGGCGGGCGTGGTGGCGCGTCGGGCCCGGTATCTGCTCGGTGAATGTCCGATGGGCGCAAGAGGCGTTCTCGCAGACGAGGCGCCGTGCCCGCAGCCCTATCCGCACGCGCCGGCCGACGACGGGACGGTCGGCCAGGCACCGCTCGTAGTAGCAGTGCACCCGTGATGATCTTTGCTCGCACTCGGGACAGGCGGCCGACACAGCCCGAGACCGTACGGCGACACACACTTCGAGATCCGTGAGCACCAGCCGGTCGACCTCCACATCCACACCCGGGAAGAGGAGATCAGCCACACGCACCGCTTCGTCCACACCCAGATGGTTCCCATCCGCCCAACGACGACAGTCACCCCCAAATCAGCGACAGAGCCCAAGATGGTGCTGTAGGGGGTGTCGGGCTTGTCGCTGTCGCCGGTGCCGCGGTAGTCGAGCGTGAGGGTGCTGCGAGCGGGATGGAAGTCGGCGCGAATCGAGTCCCACCAGTGGTGGTTGTTGGCCTGGCCCGCCAGCAGCACCAGCGGCGTCCTCTGGCCCTGGAGCTGGTAGGCGATGCGAGTTCCGTCCGGTGTCATCGCGTGCGTCATCGGCTTCCTCGCTCCCACGTGGGATCTATCCGGGCCTGAGTGGGCGGTGAAGCCGGGGCGACCGTCTTGGTGTGCTTCGTCGCCACCAGCCGTGCAGGGCAACCTCATGGCTGCCGGTACACAAGGGCGGCAGATGGCCCGCGCGGTCGGTTGCTGGAAGAAGTACCGGCCCGGCCCTCAGACACCCGCTGCCACCGCGGCGCCCAGCCCAAGCAGGACGACGCCGGTCGTCACACTGAGCCCCCGCAGGACCGTCGGCCGTGAGACCAAGGCGCGCCCTCGGCCGACGGCCCAGGTGAGCAACAGGTACCAAGAGGCACTGACGAGCGCCCACAGAGCTCCCAGGGCGACGGTCGACAGGAACACCGGGCCCTTCGCCGTCACGAATTGGGGCAGCACCGAGACGGCGAACACGCCGGCCTTCGGGTTGCCGAGGTTGGTGCTCAGGCCGGTGAGGTATCCGCCCGCGAAGCCGGTGCGGCGCCCGCCCTCGCGGGGCGGACGGGTGGAGACGGTGGTGAGCGCGGTCCGCAGCGTGTTCACCCCGAGGATCATCAGCACGATGCCGCCTGCGATCCGAAGTACCGCGTACGCGCGCGGGCTGGCCAGCAGGACAGCGGACAGCCCGGCCGCGGCGGCCGTGGACCACAGCAGGAAGCCGGTGGCGTTGCCCGCGAGCGTGCCTCGGACTGTGCGTTGCCCGCCTTCCAGAACCTGCCGGATCATCATGGCTGTACTCGCGCCTGGCAGCATCGCCAGCAGCAATGTGGTGGCGATGAAAACGGGCACATGCGTAGGCATGAGGTAAGAACCCTTCCAGGGATCGCGGCCGATGGGTGCACCACCAGGCTTCCTCTCCCGTACTCGTAAGAGAAGTTAAAAGAGAAGGGTGCAGCGTTAGGATTAGTGAATGGTGGTGGACCCGGGACAGCTCCGGCTTCTCGTGTTGATCGAGCGGCACGGCTCCTTGACGGCGGCGGCTCACGCCCTCCAGCTCACGCCCGCGGCGGTCACACAGCAGGTGGTCAAGGCCGAGCGCGACTGGCAGGTGCCCCTGGTCATCCGTGGTCCTCGCGGAGCAACACTCACTGCGGCCGGTGCGCTGCTCGCCTCCCACGGTCGAACCGTGGAGGAGGCGTCGGACAAGGCCGAGGCGCAACTGGCCGCACTGCTCGGTCACCTCTCCCTACGGCTGCGGATCGGAACGTTCCAGGCGGCTGCCCTGCACCTGCTGCCACCCGCCCTGACGGCCCTGCGGCACCGCCATCCGGACGCCGACGTCTCCGTCGTAGACGTGGTGTCCGGACGCGGAGCGGACGAGATCAGCGCAGGGCGCCTGGACCTCGCCATCGTCGCGTCCTGGGGCACACCGCTCGCGCCGCCCCCGCACCTACGCGCTCACCCGCTCCTGATGGACCCGATGGTCGTGGTTCTACCCGACGACCACCCACTGGCCACCGGGCAGCCCGCGGACAGCGAACTGCGCCTAAAACAACTGCGCGACGAATCGTGGGTTTCCATCCTGGCCGGCCACGCCGCCCGGGAACAGTTCCACGACGCTGCCCGCGAGGCCGGCTTCACTCCCACCGTGCGGTTCGAGACCGAGTCCTACGACGTTGTCCAGGCCCTCGTCGGCACAGGCAGCGCTGTGGCTTTGGTATCGCGCCTGGCCCTGACCCGTGCGCCCGGCACCACCCATCGCGAACTGGCCCGCCCCAGGCCCTACCGCCAGCTCTACGCCCTGACCAAAGCCGACGCCAGCCTCACACCACTCGCAGACATGCTCATCGACCTCCTACGTGATGTCGCCCGCGACATCACCGCCACCTGGGAGGCTCCCCTGCAAGAAGAACAACGCTCATCGGACTCACCGCACGGAGGCTGAAAAGCCCCCGGTTCTGAAACGACACCGCCTGGTCGATGGTCGGCCGGCCCCGCCAGCCGGCCATCGACGTCGGCAGCTGGCTCGGCGTCGGCCCCGCCGTAGCCGGAGCCCGGGGGTGGTCGAAGCCACGGCAGTCGGCTTCGACCACCCCGCCGCGTCGTCGGCGCTTCACCTGGAGGCTGCGGGCTGCGGTTCATCCGTCCCCTGGCCGGGGATGGGCGCGGCGGGGCCGAGATCGAGACGGCTGTTCATGCCGAGCTCGAACCGTCCGTACGGATTCACATGCGTCTAGAACAGCGGTGACAAGCCCCGGCGGTCCGCGTCGGTGAGCTTGTCCGCCCACCTCGGGTCCGTGCTGCATCAGGAGGGTGTTGACGTGGACCAGGGCGGACTGGAGAAGGTGCAGCGCGAGCATGCTGACCTCCTGGGACTCCTTGTCCGAACTGGCCAGGTCGCCGTCCTCGCCGTAGAAGAGGTCCTTGTTCGCGGAGTTCCAGTTCTCCACGACCTGGAGGCCCTCGTGGATCTCCTGGCGCATCTCGACGTCCGCGAGGTAGTCGCAGACGAACGAGGTGCGCACCGCGCGGCCCAGCTCCTCGATCGCCCGGTACGTCGGATGCTTGGGCCCGCTCCGGGTGAAGCGCCGCAGGACCTGCTCGGCCTCGGCGGTGCCCAGGTGCAGGGCGGTGGTGTACTTCACGATCTGGTCGTACTGCTGGGCGATCAGGTCCCAGTCGATCGTCTTGGTGGAGAGCACCGGGCCCAGGTTCGGCCACTGGTCGTCCTCACCGCCGGCCGGCCGGTACAGCTTCGCGGAGCCGATGTTCTTCGGCCGGGGCATCAGCTTGAAGTCGAGCATGTGGGCGAAGGCGAAGCCGACGATGGGGGCGCCGTGCGTGTCGGTGTACTGCCGGTCGATCTCCACGTCCGTGCAGTGCCGCAGCACGTGAAGGGTGTCAATATTCCAATTAGGCTGCTGAGCTGGGCGTTTCGTGTGGGTGGTGAGGCAGTTGGGGTGACATGGTGTGGTACTCGTTGATCAGTCCGCCAAGTACCTGTCGGCGCCTGACCGCGGCAGCGGGCAGGGGGATGACGTTCGGGTCGTCGTCGGGGGCGTGTAGGTCGAGGCTTCGGTGGGCCCGTCCCGTGTTGTAGTGCTCGGCGTACTGGTTGAGGACCGTGCGCAGGTGTCGTTCGCCGGTGATGAGGAGTCGGTCGGTGCATTCGGTGCGGGCTGTGCGTATCCATCGTTCGGCGAATGGGTTGGACCGTGGGCTTTGCGGCGGGGTCGGGATGACGGCTGTGCCGTTGCTGGCGAAGACGGCGTCGAACGCGGTGGTGAACTTGCTGTCCCGGTCCCGGATGAGGAACCGGAAGTACCCAGCGCTGTCGCCGAGGTCCATGAGCAGATTGCGCGCGAGCTGAGTGATCCATGCGCCGGTCGGGCGGGGGTGACACCCAAGACGTGGACGCGCCGGGTCTTGATCTCCATGACGAAGAAGACATAGAGACGTCTGAGGAGACGGTCTCTACGTGCATGAAATCGCAAGCCAGAAGCGTGTGGGCCTGCGAACGGAGGAAGGAGCGCCAGGTCTGCCGGGAGGCGCGCTGCGGTGCAGGTGGCAGGCCGGAGCGGCGAAGGAGGCGCCGGATCGTGGCGGCGGCGACCCGATGGCCAAGCCGTCGCAGTTCACCTTGGATCCTGACGTATCCCCAGGTCGGGTTCTCTCGCGCCAGGCGCTGGATGAGCGCGACTGTCTCTTCCGGCAATGGTGGACGACCGGATCTGACCGCCGTCTGGCGCCACTTCCAGCGCACCAGACGGCGGTGCCAGGTCAGCAGCGTGCCCGGGGTGACCAGCCGATGGCGGCGCAAGGCGGATGGCAGGTGCCGTGCGAGAGCGGAGAGCACGGCGCGATCAGCCCATGAGAGCTTTGGCCGCTTGATCTGCCGGCGCAGCACGGCGACCTCATGGCGAAGGGCAAGGATCTCGGCGTTGTTCGCGGCGGTCGAGCGGCCCAGCAACAGGAAGCAGCCCAGTAGTCGACAGAAGATCAGGTAGAGCAGTCGCAGACCCACGATCACTGATCATGCCCATACTTGAGCGATCGCAAAGCCCCAGGTCAACCACCGTAGGGCAATAAAGACACCCTTCAGGCTCGGCCTGCCCTCTCCGATTCCGTTGTGTGGGCTGCGACCACTTCTCCACCGACGTCTCCTACCTCCCCGACCTGCGTACCTACCTCGACGACCTCCTGCTGCAGCGGGAGAAACTGCGGTCGATGGCCGAGGCGGACGACTGGGCCCGAGCCGAGGCCATGCCCTCGGACGCGGAGATCACCCGCATCCGACGTCTGATCCAGCGCGTCACCGAGGACGTCGAGACGCTCACCGAAGCCGAACGCGCCGAGATCCAGCGGGCTGCCCAGGTCGTCCGCCGGATGCGGCAGAACTTCCTCGGCATGCCCCGCATCCGCCAGCCCCTGCCCGACCTTCGACCGGAGCGACCCGCATGACCGCACCCGACCCCACCGTCCAGGCGATGATCGAGGGACGCCGGGCCGACACGGGACGACGGCGCCGGCGTGTGCTCACCGCGCTGACCCAGGCCGCAAAGGACGGATCGGACATCAGCGTCGCAGCGATCGCCCGCCGCGCCGGCGTCGACCGCACCTTCCTCTACCGCCACCGCGACCTGCTCGGGCAAATCCACGCCCGGGCCGCCGAGCCGCCCACCACCCCCGGAGGCCGCGGCCCCGCCGTGAGCAGAGCCTCCCTGCAAGCCGATCTGCTGGCCGCCGACGCCCGGACCGCCCGGCTCGCCGCCCAGGTCCGCCGCCTCGAAGCCCGCCTCAGCGAAGCCTTGGGCGAGTAGGTCTGGCGCGAGTCCGGCATCGGCGGCCCCGAGGACACCGAGCAGTTCAAGGCCCGGATCACCACCCTCGAACAACAGGTGATCGACTTGGAGCTGAAACTCCCGGAGCGGGACGACGATCTTGCCGCCGCCCGCGCCGCGAACCGCGAGCTGATGGCCCGGCTCAACCGCCACACAGATTGATGAAGAAGGCCGTGAGCAGCTGATCCCAGGGGGCGCCCGAGGCGGTGACAGTGGCACTGCCTCGGGCGTTCACTGGAGGTATGGCCACTTACGACGCTAGCTCCGTAAAACGGCCTCGCCGCACAAAAGCGCAGGTGGAGGCCCTACGGGAGGCGATCTGCGAGCTGGTGGCGGCGGCACAGCCGTGCAGTGTCCGCCACGTCTACTACCTCGGCATCGGGCCTCTGTGGGACAAGGACACCGGCCACTCCCGCCGCGACTACTCCGTCGTCGTCCGCGAGGTCGGCCACCTGCGGGAGACAGGGCGACTGCCCTGGGGGTGGATCACCGACGGCACCCGCATGGTCCGCCAGGAGACCCAGTACGACTCGCTCGACGACGCCATGCAGCGCAACACGGAGACCTACCGGCGCAACCTGTGGGCCTCGCAGTCCCGCCGCGTCGAGGTCTGGTGCGAAAGCGACTCGGTCGGTGGCGTACTCCTGCCCGTCACCTCCGCCTGGGGCGTGGGCCTGTACTCCTGCCGCGGCCAGTCCTCCAAGACCTTCGTCTACGAAGCGGTTCGCTTCGGGCGAGGGTGAGTTTCGTCGACGAGGTCAGCGAGACAGTCCAGCTGGCCCGGACGTCGCGTCGCTTCTTCGATCCGCCCGACAGGGATCAGGCCGTCGAGGACGTCGACGACGAACTGGGACGCGGGGCATGGCTTCGAACTCGTCTCGTGAGTCGTCGTTCAGCACCGTGTGCGTATCAGGTGACGGATGCTCAGCGATGGCTGGGCCCGCCGGTCAGTCGATGCCTTCGATGATGCGGAAGTCGCGCTCGACGCCGTCGGGGAGGGCCGCCAGCGCCTTCTGGTATGCCTCGCTCTCGTATGCCGCGACGGCCTGTTCAAAGCTGTCGAACTCGATCAGAACGACGCGTTGCGTGATTCCGGCCTCGTGGGCGACGACTCGACCGCCACGGGACAGGAGGCGCCCGCCCCCAGCCTGGACAGCCGGACGGGCCAGCTTGTCGTAGGCAGTCAGCCTCTCAGGGTCGGAAATGGCGGGGTAGACACTGACCCAGTAGCCCTTAGCCATGGAAACCTCCTGTGTTCGGCCGGACACGTCCGACTTCGAATTGACACTCAGATCGATCGATCCCGGCGACGGGTACTGCGGTCAGTGGAATCGTCATATGCGCAGGTTAGGGCTTGATGTGCCGTCGAGGGAAAGACCGGTACGGGATAGACTCAGAACGGATCGTTATCAATCGGCAGGGAGGGCACGTGGCGCCGGATACGGTGAGCCTGCGGTACTTCCTGGTGCTGGCACAGGAGTTGAACTTCACCCGCGCGGCCGCACGGATCGGTATCGCACAGCCCGCACTCAGCGCCCGGATGCGCCGATTGGAGGCGGAACTCGGTACGGCCCTGCTGGTCCGCAACACGCGTAGCGTCGTATTGACCACGGCCGGTGCGGCTTTGGCGGAGTCCGCGCCGCCCGCGCTGGCGGCGCTGGACCGGGCATGGGACACCGCCCAAAGCGCGGCGGCCGGTGAACTGGGCACGCTGCGCATCGGATACAGCCTCAGCGCCGGGGCCGAGACGGCACCGGCCCTGGTGGACAGGCTGATTCGCGGCAACAGCGGACTCGAGGTCGGCGCGGTCCCGATGGCGACACCGGAGATCTCCCCCGCGGTCGCCGACGGCCGCATCGATGCCGGGATCACCCGCGGTGAACAGCCGGGCCGTGGCGTGCGCCGGTTCCTGCTGCGGCGTGAGCGCGTCGGGGTCCAGCTGGCGCAGCACCATCCGCTGGCCGAACACCCGGAGATCGAGATCGCCGACGCGGCCGCGTATCCGCTGCGACTCCCGGACCGTGCGGCCAACCCCGTGATCCACGATCAGCTGTCCGCACTGTTCCGAGACACCCGACCACACCCCCGATTCCACACGCCCGCAGTCTCTTTCGACATGTCTCAGCGCGACCTGCGCGACGGGGTCACCCTCGCCCCGGCCGGAGAAGCCGCGGTCACGGCACAACCGGCCGGTCTCACCTGGCGACCGCTGCGAGGCGCGCCCAGCCTGACGATCCACCTGGTCCTCCCACGCGAGCAGTCGCCGCTACACCGCCGCATCCGTGCCGTCGCCAAAACCCTGGCGCACGAGCTGCACTGGCTGCCGGACTGACGCGCAAGAGGTCAAGCGAGACGGACGCCTGCGGTGGCGAGGCCGAAGACCTTGCGCCCGGCGGACTTCGCGGTGATGACGACGGCGGTCTTGCTGAATGTCCGACACGACCTCGCTACGCCGGCGGATCAGCATCCGATGATGGCCCCGGGTCCGGTCCGAGTCGTACACCGCGGCGACGTCCTCGCCCAGCCCGAGATCTCGGCGGATACCGCGCCTTCGCCGACGCCGAACCGGACAAGCACGGGTAACCGGCGGGAACGCCCGCCGTCAACGGCGTCCATGACGTCGGTCAATGCTTAACGCCAACCACTGTTCCATTGCTCCCCGAGGCCGGAGAGCCCCGCGGGTTCACGGAAACTGAAGCCTGCTCAGTGGGAACTCGCGGGTCAGTCCGTGTGCATCAGCTGAAGGCATCCGTGGGTTCGGTGGGAACTTAGAGGTGGGCTGCGAGACGGCGAGCCTCTGCCGTGACCTCTGCATCGACCTGTGCCGCTGTCTTGTCTCCGTATTCGAGGGTGTCGTACTCGTCGTCGAGTTCGGCGAGCCGTTCGGTCAGGGCCAGCTCGTGTCCGTGGCGCTGGTGGATCCGGAAGGTGAACTCCCGAGGTGTCAGCTCGCCGGCGAGCATGCGACGTGCCAGGGCTCGCGCGGCGGCTTCCTGGCCGGCTTCACTGGCAACTGGATAGAAGGTGAGGCCGAGCTCTTCGAGTGCCTCGGGGAGCAATGCGTGCACGTCGTAGTCCGCCTCAGCACGCGTGCAGGCTGCCAGGATACGAAGCCCGGGGCTGTCGAGCCCGGCGACGAGCGCATCACAGGCGGCATTGACGATGTCGCTCGCCCGCGCGTCTCCCATGCTCCAGAGGGCGGCATGATCCTGGAGGGCACTTGCTGCTGCTTCAGTCGACGTCACCCATCCATCATTCCCTTCGCGGGATGTCCCGGTCGAGCTGATTTCGTCGAAGCTGCTGTTCAGCGGCCTGTTCCAGTAGAGATCGTGCGGAGTCCGCGTAGCGCATCGCGGTCTTCTCATCGAGACCGAACACCTCGGCGAGGTGGAGTGGATCGGGCCCGTGGGTCAGGGCCTCTTCAAGTTGCCGGTCAACGCGGAGTCGCTCCAGCGTCGCGTCCTGCCCGCGCATCGAAGCACTGATCCAGTGGTTGCTGGCGCGGCTGGTCTTGGTGGCGGTCTGGTTGTTGATCAGCAGGTGGAGGTTCGCGGTGTTCGGCCACCGGTTTCGCCGGTGCTCCAGCCACTCCAGCAGCAGTTTCAGAGTGAGGTCGTCGAGCGGGCGGACGCGTCCGGCGATGGTCAGCCGGCGGTTGCCGAGGTCGACGTCGTCGAGCATGAGCGTGCCGATCTGGGCGACCCGGGCGGCGTGCACCGCGGCGAGGGCGAGGATGAGCCGCGTCGCTGGGGTGGTGGCCGCCGCGACGGAGCGGTCGACCTCGGCGGGGGCGAGCGGTTGCAGTACGGCGTACTCGTACTGTCCGACCTTGATCCGGATGGTCGGGTTGCGGAAGATCAGCCCGTTCCGTTTGGCCCAGATGAACAGCGAACGCAGGGCGACGAGTTGGTCGTGCCGCTGGCGGCCGTGCAGTGTCTTGAGGTAGGCGAGGACGTCGTCGCGGGTGACTTCCCGCAGGTGGTCGTAACGGTTCGACCATTCCAGCAGGGCCGGACGGACTCGGTTGAGGTAGAGCCAGACCGTGCCTTCCCGTCGCGGGAGGCTGCGGGGGCCACCATCGCGCAGGACGCGGGTCCAGCGCTCGGTCTCCGAGCGGATGGCGGGTGCGAGTCCCTCCAGACGCTCGGCGAGCCAGCCCTCGAAGGAGGGTTCGCTGTCGTCCTCGAAGATCCCCATCTCCTCCAGGACCGTGACGACGTGGCCGAACCGCAGGTCCAGGGCCCGCAGCGGGGCGAAGATCTCCGTGTGCCGAATGACGTCGCCCTCGACGTAGCCGGTGAGGACGAGGGCCAGGCCGCGGTTGACAGCGAAGCGGATGCCGCGTCCCCAGCCACGGGCCTCGGCGAGCTGGTAGGCGAGGTACTTCGCCCAGGCCAGCCAGGGGCTGGCCAGGTCGGCGTCGGCCGGGTCGAGACGTCCGTAGTCACGCGGGACCTGCCCGAACAGCGGTAGCTGTCTCCAGTCGGCGCTCGGCCGCCAGGCCGGCGCGGGTGGAGGTTTCCGGACGGCTCCCCGCCCCCCTCCGCGTCGCGCGACGACGGGCGCGGATCCTCTGCGGTAGTGCAAGCCCATGAAGAACAGTTGGTGGTGCCGGACGGCGTTGAGCCGGGCTCTCACGTCGGCCTCGGCGGGCGGGCGACCGGCAGAGGCCTTGGCGTGGAGCCGGGCCTGGCACCAGCACAGACGGCAGTAGCCCCACTTCAGCGGCTGAATGCGACGGCAGTCCGCGCAGGCGGCCGTCTCGTGGCTGCGGCCGAACATGTAGCAGGCAGGACAGAGTCGTCCGCTGAAGTCACCCCAGGCCAGGCAGCCGTCGCAGGAGTCGGTGGGCTTGCGGTAGCCCTTCGGATACCGGCTCATGCAGGCGGCAGCGACCGGCCGTCGCGGCGCTTGGGTACCACCACCGGAACCGGTGCGGCGGCGCCGACAGCGGTTCGGGTGATGTTCTCCTCGCCGGGGCGGGTGACCTTCTGCGGTTCCGGGATCAGCAGGTCGCTGATCTCGCAGCCGAGCACGACGCAGATGACATCCAGGTCGTCCAGTTTGAGGGAGACCGGCTGGCCGGACCACAGTCCGGACATCTTCCCGGCCGAGATCACCAGGCCGTGCTCGGCCAGGCTCCGCTGGAGCTCGGACGCCTTCCAGATACCCTTGTTCGCGGCGGTCAGCCGCAGGTTCCACCTCATCGGGCCAGTCCTTCCAGCCGCTTCGCGGCCCGTTCCATCCCGGCAGCCCAGGCGTCCTCGACCCGGGTCTGCTGCACGTGGATATACCGCATCGTGGTGGCGATCCAGGAATGTCCCAAAACCTCCTGGATTGCGAGCAGGTCCAGCCCATTCCCATAGAGTTGGGACGCGCAGAAATGCCGTAGGACGTGCGGCGTCAACTTGTCCATCCAGCCCGGCAGATGAGCCTCGACGGCGTTGTCGAGACCGTTGCGCAGGGCGTCATCGCCGACCCGGCGGGCGGAACCGTCAGCGTTCTTCCGCTCGCTCGGGAACAGCGGGGCGCCGGGCCGGGTGTGATCGTCGTCGAACTGGCCCCACACGTCCTCGATGAACCACCGCAGCGTCCGGTCGGCACCGTTGATCAGCGGCACCATCCGCTCACGAGGCCCCGAGCCGCGGGCGCCCTTGCCGTGGCGGACGTGGAGCTTGCCGAAGCGGCCCAGGTCCCACTTGATGTCGTCCAGGTCGAGGCCGCATGTCTCGCTCACCCGTAGGCCGACCTGGGCGGGCGCCCAGTGCTCACGTCACACGAACCCGGGAACCCTTCACCGGGCCGCCGCCAGGCGCTCCGGGAGCCGCGTGATCGCGGCGGCCACGGCGAACCCGAGTGTGACGCCGACGGCGGCGGCGATGGTCTTTGCCCAAGCCGCGCCGAGGGAGCCGGGCAGGACGGCGCTGGTGAGCCAGCTCGCGCCCGACAGGATCGCCACTGCGGCCAGCGCGGCCGGCCAGCGGTGCCGTACCCCTTCGATGATGTCGTCGACGACATTCAAGAGGAGCATCATCGCCATGATGTAGGAGCCGCCGAACTCATCGTCCCAACCCACCGCGGTAACCCCGGCCCCGAAGGCAAGCACCGAAAGACAGAGCCCTATCACCCGCCAGCAGGGAGTCGGTTGCTTCCGACTCGCACCACGCGGGATCCAGAAGAACCGCGTGATGCGCTGGACGACCGTGTACTTCTGCATGGCCCGCGTCCTGTCTCCCCGTGGCCGGCTCCTGTCGGCGCTCAAGAGTGGGACGCACGAGATCGCGCAGCGGTTGTGGAGTCTCACTGCGAATCAGCGCGGGCACGGTCGCCCTCACGACCGCGGCAGGAGCGCGGCTATTGGTGGCGCCAGTGGTCGTGGACCTGCTGCATGTCTGCCTCGAGGACGTCACGCAGATCGTCGTCGTCATCGGGCAGGTCCAGGCCCAGCGTGCTGGCGACCTTGCGGTAGGACGTCAACTGGCGACCTCGTGTAATCAGGAGTCGCGTATTCCTCAGTTGCTGAAGGCTCGTGGTCACCGTGAGTGGTGGTCGCCGGGGGCCTTCGCAGACCCCGGGCCCTCGCTCCCCGCGACACCGACCGGCGCGGCAAGGAGGAGGGGGTGCGGCCAGTGCGCGCCGGACGGCACCGCGGCTCGTGCGCCATCGCCAGGAACGGCACGGGGGTGTCGCACGACGACGGAGAAGCCGTTACTTGGTCCTGCCGTGCTCGAAATCCGTCCCTGAATAATGGGACTTCGTGCTGTGCGGGGGCCTCGTTCGTGACATACTCGCTGCGCGCTCCGCATCCCCCGTCGGAGCGACGGATCGACACCGGGCAGCTCCTCCCGTGAAGATCTGGCGTCGCCACCAAGGGGCCTTTTTTTTTCCCAAAAACAAGCCGAGGAGATGATCCATGAGCAATGAACCCAAGCCCCGCAGGCGCTGGACCGCGCCGGAGAAATGGCAGGTCTGGCTGGGCCTGCTCGGTTTACTGACGGCGGTCACCGGGTGCGTGGAAGGGTTCGTCAGGTAGCGCATCCACCCCAGTGAGACGGTCGCGGCCGGCACTGCGCATGCAGAGAGCCCGGTCGATATGTGGGCGACCGGGCTCATGAACTGCAAATTGAGGGGCCTGGCTCTGGCAGGAGCTGGGCCCCTCGTCATGTGCGGCCACAGGGCCGCACTACCGTCCGAGACCCTACGCGTCGCCGTGACGGCGCATCAACCGTCGGTGCACGCCGAGGTCCTCGCAGAACGGGCGGTGCGGCGGGACGGACGCGAGCCGCTTGGGCTCGCCGCCGCGATCTCCCTGATGATGACCGAGCGCGGCATGGTCGCCCCGGCCGCCGGCGGCAACGTCCTCGCCCTTCTCTGCACCAAGTCGGCACTGCGGTTGCCCGACCGGCTACCGCTTGATGCGGCCGCGGACGGCGAGGGCCGCCAGGCCGAGTAGTACAGGTTCGAAAAGTCGGGATGCCATCTCAGTGAGTGGTGTGCATCGTGAAGTTGCTGGTCATGGGTCTGGTGTGAGGGTCGGGAGAGCTGCTCGCGCTGGTCGCCGGCCGGTGCCCATGGCGGAGATCGTCTGACTTGTCGTTCGGGGCCGTGCTCGGGTTCTGCTGACTTGCCGCTCGCTGCGGAGTTGGCCGAGCAGTTGCAGGAGGTCCAGGCCGAGAGGGAGGGGCTCGTGATCGCCGAGCGGGTCCTGAACCGGCTAGCCGAGCAGGATCGCGCCGCGGCAGAGGCCGCCGCGGCCGTGGCCCCGGCGCCCGCCCGGGAGGGGGCTGACCCAAAAAGAAGCCTGCCTGCGGCTGGGCGAAGAAGCCGAGTCCCGCCGGCCAAGCCGGCCTACGAGGAAGGCTCGGGGCCGTCGTCGCCGAACTGCCGGTGTCGGGTCATCGAGCGGTGAGGACGTGCGCCCACGGCTCATCGATGTCGGCCAGGCCCAGCACGGCGGCCACGTTGTCGAGCATGCCGGCGCCGAACCAGCGCCGTACGGCGTCGTCGTCGCCCAGCAGTTGCCGGACGGTGTCGACCTGCTTGGCGTAGCACCGGCGTACGGCCTGTGCCACCAGCGGCTCGCCGGCGGCACAGTTCGCGTGCATGAGGAAACGCAGGATGTTCCGGTCCGCGACGAGCGCGGAGTAGGCGCCGCGTGCGGCATCCAACGCCGCCTCGGGCGCCGGCTTGGCCCCACCCGAGGCCGGTGAGTGCGCGACCAGTGTTTCGGTCATGACGACGGACACGTGGTCGACCGCCGCCGCGAACAGTGCTTCCTTGTTCGGGTACAGGCGGTAGAGATACGGCTGTGAGATGCCGGCCCACTGGGCGATCTCGTGTGTCGTCGTACCGTAGAAACCTTTTTGCGCGAAGCAGTCGACCGCGGCGGCCATGATGGTCCGACGTCGTTCGTCGCTCTTCGTGCTGGTGCCGGGGGCGGGCATGGGCGTCAGTTAAACACGGCTCCTTTCAGCTTCCAAAAGTCACGCTGAGGTCAGGGTCGGACGGCACGTCGTCGGGTGTGAGCGCCTCGATCGCCACCAGCGGGTTCCAGTAGTCCAGGTAGTGGGTGATGCGCGCGTTGTCATCGGTCCGGACGACGGAGATGCACGTCTGCTCGTACGGCTTGCCGGTCGGCAGCGCAGTGCCCTTCGAGCGGAATTCGGCGATCACCAGACTCGGGTCGACGGTGTCGTGGAAGACCAGGTCGACGAACTCGACGTCGAAGGTCTCGGGAAAGTTGCTCATGTGCGCGCGCAGTGCGTCTCGCCCCGTTACCCGCTGGGGCACGCCGGCCGGCGCGTACGGGAACTCGAGCACCGCGTCCGGGGCGAACAGCTCCACCCATTCGTCGGTGCGTCCTGCGGCGGTAAGGCGCAGGTGCTCGGCCAGGGCGTGCTGGGCAGCGGCGCGGCGGTTGGCGTCGTCTTCCTTGACTGTCATCTTCACTCCTACGTTAGTGGTCGACCTATAACCTACCACGCTGCGAGCCGTTGCGAGTAGTCGAGCAGAGGTAGCGCCAGGGGATCCCGGTCCGGTTCACGTACAGGATGGCGTCAGGGAAACGCCCCTGCAGTGGCGGGCGGCGCCCCGGTACTACCAGCGCCCGTCACGCTTCGGTGAAGATCGTCGGTCACCGGGAGACTTCGCGGTTCGTAAGGACCAGCAGGGCCCTGACCAGGGCGGTCGCCCATTTGGGGTCAGTGCGGAGCCTGCCGAGCACGCGCCAGTTCTTGAGGTGGGCGAATCCGTGCTCGACCGGGGCCCGGACGGCCGCCAGTGCCTTGTTGGACAGCTTCTGTCCCCGTGTCAGGGGCCGGTTCCGGGTGGCCTTGTAGCCGGTGATCACTGCCGGGTCGATGTCCGGGCCGCTGTCGTCAAGTCCGACGAATCCCAGGTCGGCGATGGCGCCGAGCCCGGCCGCCCGGAGTCGGGCGGTGAGCTCGTCGTGACGGCAGGCGGTGATCTCCGAGGTCCGTCCGGGCCGGGTCGCCGAGACCCAGAGCAGCCGGCCCCTGTCGTCGGTAAGCGCGATCACGAGCAGACCATGGCACTTGTGCTTGCCCAGTAGTTCTTCCGGTTCGCCGTGCCGGTGCGCCGCCGGGTGTGGATCAGCGTGCCGGGACCGCTGTGGCGGTGGGGTGGGGACGGTTCCGCCGGGCGGCGAAGCAGGTGCTGGTGTCGGCGGTGCTGGGAGCGGGGTGTGCCGGGCTGGGGGAGGGGCGGTCGGCGGTGGCTGGGCGAGTGTGATGCCAGCGGGCAGGATGGCACCGGTGTCCCGCGCGAGACTGCCGCGTTCCTCGTTCTCCTCTTGCCGTTGCTGGTAGGAACAGGCGCGGCTCAGGGGAAGACGAGCTGGTTCGGCGTGGTCCTGGTCGTCGACGTTCCCAGGTGGTGGCGTAACCCGGAGGACGACCTGCCCGCCGACTTCGAGGACAACCGGGACGTCCACTACGCCGCCCTGGGCCAGCCGCAGGACGCCGGCGAGTTCATCACCGCCCTGCAAGGCAAGCTGCGGACCTCGGTACACCACCGCCCTGCGCCTGGGCACCGCCGAGGCCGAGCAGGTCCTGCGCCGCTTCACCCGAGGCGGTCCCAAGCACCCCACCTACCAGGCGATCGAGGAACTCGGGCGGGCGGTGCGTACATCGTTCATCTGCGACTACCTCGCCGATGTCGAGATGCGCCAGGAGATCCACGAGGGCTTGCAGGTCGTGGAGAACTGGAACTCAGCGAACAAGGACCTCTTCCACGGCAAGGATGGCGACCCGGTCGGACAGGATAAGGAGTCTCAGGAAGTTTCCATGCTGGCCTTGCATCTGCTCCAGTCCGCCCTGGTCCACGTCAACACGCTGCTGGTGCAGCAGGTCCTCGCTGATCCGAAGTGGGCAGAGAAGCTCACCGATGCGGACCGGCGGGCACTGTCCCCGCTGTTCTGGACCCACGTCAACCCATACGGACGGTTCGAGCTGGACATGAACAGTCGTCTGGACCTGGACCTGGCCGTCGCGGTAACGGTGCCCGGCCCTCGCCGTGCGCAGGACGTGGTCGCCTCTGCGCCGGTGTGACATCGGCGGACGTCGACAGCGGACCGCCCTTCACCTCACCGGCCTGACAGGGTGCTCGGACGGGTCCGTGACGTGCGGAGCCGTTCGACACCGGTCTTCAGAAGGCAACTCGCCGCTTCAGGCATCGACAGCGAGAGTCTCATGAGCGTGGGCACCCGCGCCTACGTCTCGGCTCTGGACCGTTGCGGCTGCATGGTGCAGTTCAGTGAGCACCGTCCGTACGGCTCGCCGTGCGGCACGTTCGGGGCGGTGGAGCACATCGATATGGCGTCGGGTGTGCACGCCGCTGAGCGGTCTGAGGATCAGTGCGGGGTGCGGACGTGTAGTCCAGCGTGGCATCAGGGCCAGGCCGCCTCCGGCGGCTACGGCTTCGGCGACCACCGCGAATTCGTTGATGCGATGGACGATGTTGAGCCGTCGGTTCGCGGCGGTCGCGATGGCGTCGATGGTGGCCATCAGCGGGAAGCCGTCGTGAACGGTGATCCAGGGTTGATCGGCGACGTCTCGCGGGGTGAGGCGTCGTTTGGCGGCCAAGGGGTGGTCGGCCGGCAGGGCGATGTCGAGCGGTTCACGCAGCAGCGTACTGGCGGTGACCGTAGTCGGCCACGGTGGCGCTTGGTCGAGACGGTGGGCGAGTACGAGGTCGTAGTCCCGGGTCAGTCGCGGGAAATGGTCCTGCGCGACGTCCTCGTCGGCGAGCGAGAGCTGCGGGCGTCCGGGGCCAGCCTGGGCAAGCAGCAGTAGTGGGAAGAATGCCGCGGCCGCGCTGTGGAAAGCCGCCACCGACACACCCGCGTCCGGCCGGTCGACGAACTCCTCGATGGTGTGCCGTGCCCTGGCCAGCGCGGTCTCCACCTCGATCGCCGCACTGGCCAGGGCTTGCCCGGCATCGGTGAGCACCAACCGCCGTCCGTCACGCTCGGTGAGTGGGACCGGGATCGAGCGTTGCAGCAGCCGTAGCTGTTGGGAGATTGCCGAGGGAGTCATCAACAACGCCTCGGCGGTCGCGGTGACGCTTCCCAGCTCGCCGAGCTCCCGCAAGATCTGCAACTGCCGTTCATTCACCCTCTCAGTGTAGTGATGCTTCAGGATTTTTGAAGAACCTCGCCCTTGGCTTCAGGGTGGAAGCAATGCAGCGTAAGGGGGTGTTCCACGCCCGCCGCACTGACGCAGTGCTTCTCCTTGTCGCCATCGTCTGGGGCTCCAGCTACCTGGCCGCGAAGACGGCCACCTACGCCCTGCCCGTCCTGATGGTGCTGTTCGCACGGTATGCGATCTCCGCGATCGCTTGCCTCGCCCTCGTCGCCGCCCGCCGCCGGAATGGGCGCTACACGCGAGACGAGGTGCGTGTTGGGTCCCTCTTGGGGGTCACCCAGGCTGCTGTCCTGGTTCTCGAGACGTACGGCGTCGCGCACACCAGCGCGGCCAATGCCGGCCTGATCATCAGCCTCACCATCGTGCTCACCCCCCTGCTGGACCGCACGGCAAGCAACGGCCGGCTGCCCCCGCGCTTCTTCGCCGCCACAGGCGTGTGCCTGCTGGCCGTCACACTGCTCATGTCCGGCAGCGGCTTCCAGACTCCCCGGATCGGCGACCTGCTGATGGTCGCCGCCGCGGTGGTGCGCGCAGTGCACGTTGCGCTCGTGGGGCGACTGACGAAGGGCCGCGTTGTCCGGCCCTTGCACCTCACGGCCGTCCAGACGGTTGTCGGCTCGGCGCTATTCGCCGTGCCGGCCTCAAGTGGCCTGCCGAGGCTGACTCAGGTCGATGCCGCGGTCTGGAGCCAGCTCGTCTATCTCGCCCTGTTCTGCAGCGTGTTCGCCTTCCTCGCCCAGACCTGGGCGGTACAGAACAGCTCCGCAAGCCGGGCAAGTCTGCTACTAGGCACCGAACCGGTCTGGGCCGTCGCGGTCGGCATCGGCCTCGGCGGCGAAAAGTTCTCCACCCTCGCCGCCCTCGGGGCGGCGCTCATGGTCACCGGAACGTACTGGGGACAGAGCATCGAACGCACCCACCGCACGACCAACAAAGAGGAGCCCCCATGCCGGACAACGACACCTACCAGCGTCTGATCAACCTGCTCGACAGCACCGCAACCGTGTACAAGCTCATTGACCACGAACCGGAAGGCACAACCGCAACGGTCAGCGCACTGCGCGGACACCCGGTGTCGGAAGCCGCGAAATGCCTCATCCTGATCGTCAAGATCGACCGGCGAGTCACTCGCTACGTGCTCGCGGTCGTCCCCGGCGACCGGCGTGTGGACCTCAACGCCATCCGCACGCTGTTCGCAGCCCGCTACGTCGGTTTCTGCGACGCAGCCACGGCCGAGCGACTGGCCCACGCCGTCCCCGGCACTGTCCTGCCCTTCAGCTTCGACCCCGAACTTGAACTCGTCGCAGACCCGGACGTCATTGCCCAGCCCTGCCTCTACTTCAACGCTGCCCGCCTTGACCGCTCGCTGGCCATCTCCGGCGCGGACTACACCAGGCTCGCCAAGCCGCGCGTCGAGCGCATTACCAGTCCGGGCTCGAACTGACGCACTTCACGGCCCGCTGATCCGGTCCCCATCCCGACGGGGGGGGCTGTCCCTCTCATAAACGACCCTTTCCCGGAGCAAGATCAAGAGCGGTCCGCGATGACGGTCTGCAACCCGGATCCGCTGTCACAACTCGTTCTCACTCAAAAGCGGGTTGAGGTCCATTCTGGGAAATGTTTGTGACGGTATCCGAGGTCATGACGGTCCCTCAAACCGCACTCGCGTCCGATGCCGACGATGTCGAGCGCCATCCCTGCTCCCGCTGTCACGCATCGCCAGGTTCGCCCTGTCGCTCGCGGTCCGGCGCGGTCGCCGGCACCTACCACACCGGCCGCTTCACGAAGGTACCCCGGCTCGCCAAGCTCCTGCGCGTACCGACCCCCGCGGACCGCGGTCCCGGACAGCCGTGGCGGCCCGGCACCCTCCTCCCGGCACCGATCGACCCCGACACCCCGACCGCGGACATCCGCATCGGATACGCCAGGTGCTCCAGCCTCACCCAGGAACTCCAGTCGCAGTTGGACGCGCTCGCAGCGAAGAACATCCCCCGGGACAAGATCTTCGCGGAGAAGATCAGCACCCGGGTACGGGTCCGTCCACAGTTCGAGGCCGCGCTTGCCGCCGCTCGCGAGATCAAGGCCCACGCCCCGCACTGCCGCGTGATCTTCACAGTGAACGAGATGAAACGGCTCGGGCGCGACGCAGCAGAGCTGACCGCGCTCGCTGACCGTCTCACCGCGCACGGACTGGTGTTGGAGATGCTCGCTGGACCTCTGACCGGGATCTACGACCCCACCGGACCCGGCCGCCTGCTGTTCGGCTTCTTCGCCGCGATGGCCGAGACCGAGCGCGAGAACATCCGCGAGGCCACCCTCGAAGGACTCGATGCAGCCTCCCGCAAGGGGAAGCACGGCGGCCGGCCGCCCGTCATCACCGACGACATGCTGCACACCGTGCTCCGCCGCCGCGCGAACGGCGAGACTGTCGAGCAGATCCAGCCCGACCTGCTGATCCCCACCGGCCGCCGCAAAGGTCAGAACCCCAGCCTTTCAAGCATCTACCGGGCACTCGCCGAACACGAGAAGGCCCAGGCATACCCCGAGGCCATCGAGCAGGCCCACACCGACTTCGCCGCGTTGACGGCTACGGACGACATCGCCCGGCCCCGCCCGGCCCGCACTGTTACCTCCGGCATCGAGTGACCAGATCCGAAGACCGTGCCCAATGTAAACAGCAACTACTGAGCGTTACGTGACGGGTGGCGGCAGCTATACGAGAACACGGCCTACCTGCGTGCGGTGGTGGCCGCGCTTGGCCCGGATGCCGGATCCACGAGCGGGTTCACCTGGCCGGACCGGTACCTGACCGACCCGGAAGTGGCGCTCTGCATCGGCCTGAGCGGCACGCACGTGCTCTTCTGGAACCCGTTCGCCAGCGGGTGGTTCTGCGACCGGGTCGACTCGGAGGACCACATGCTCGACCAGGCCCACCAGCTCATCGAGGGGGCGGTAGTTCCCCGACCCGACGGTGTGGTGGCCGCGGCTCGGCTCCAGTATCTGGTGCGGCTCGACGAGCTGCCGCTGCGCGCGGCGGAGACCGTGGTACCGGCTGGGACCCGGCTCACCCCCGCCCAGCAGGTTGCAGTGGACCGCGGGGCCCTTACTGAGGACGTCGCGCGACGCCTGGCCGTCTACGCGGCGGAGGAAGCGACGCTCGCCCGTACGTGACCGGCACGGGCTGGGACTGGTGAGCTCGCATGTTGAGGTGTCGCGTATTCCGGACGGATGCGGGCCGCCGTCACTCTGCGTCAACCGCGGATGCGAGCTCACCAGTCCCGAGGCCGTAGTAGAAGGGCGAGGGCCCGTCGATCCCTGCCGGCTCCAGGAACAGCCCCTCGTAGTGCTGCAGCGGCTCCATGCCGAAGTCGACCTCCGGGGCCGTCCCCTCCTCCTTAAAACTGCCGAGAAGAAGCTGCGTCCAGCGCTGCTCGACAGCCGACCACACCACCAGGTGCGAGGGCGCGAAGAACACCCACATGGCGTCGATCTCGTCTGGCAGCGTCGGGGCAGTCAAGGCGTGCGCGATCACCAGGTCGAGACATTCCACGTAGGGCCGGTCGAGAAAGTGGGACACGATGAATACCACCCGCGCCCTGTCGGGCGAGGACTTGTCCCGCAACTGCTTCGCGGCATTGGCGATCATCGACTGGGCCGCCTCGACGACATGCAGGGCGTTGGCACGTTCGGCGACAGCGTGGACGCCCCGGATCAAGGCGTTGAACGCCTGGTCGGGCTCGGCGAGTTCACCGCCCAGCCGGGTGGCGAAGACCCCGCAGGCGGGGCCGTTTGACCTGATCGCGGATGGCGAGTGTCCCGATATGCGGCGAGCACGGCGCCTGTGGATCATGGAGTTTTCCACGCTTCAAGATCCGCAAGGTTGCCGTGCTCGTTGCTCTATCTTCCTTCATGCCCGGGGTGCCGTGTCAGTTCGTCGCGAGTCGGCCGGGGACAGCGGAGCGAGGAGGCGTCATGGACGGCGGTGAGTGGCTGGCGGCGGTGATGGTCCACCCATCAGCACTGGCCTCGGGCTTTCGTGCGCCCAGCAGAGCAGGAGGTGAGGTTGTAGAAATCCGGTGTCCCGAGACTCCGCCAGGGCCGACAATGATCGTATGACTGATGTCGCGATCGCTGACCACAAACCTCGGCTCGCGGTCCTCACCGGGGCTGGTATCTCCGCCCCATCGGGGCTGCCCGTCTACCGGGGCGGCAACGGCATGTGGGACCGCAACCCGGACACCGCGAAGTTCACCACCGCGTCCCGCTGGCACGGCAAAGCCCAACAGTCGTGGGACCACTGGAACGAACTACGTCGCGCCTCATACACCGCCCAACCCAACCCGGCGCACCAGGCGTTGGTCGCTGCCGAAGCCCACTTCGACGTGCACATCGCCACCCAGAACATCGACGGGCTCCACACCCGGGCGGGATCCACGAACGTCACCGAACTCCACGGCAGCGTGTTCCGCACCCGCTGCTCCGGGAAGGCATGCCACGCCCGCCACGGTGCCTGGTTTGATGAGAACCTCCACGAAACCGTGCCCACCTGCCCGCGCTGCGGGCGCGTTGCCCGCCTTGACGTCGTCCTGTTCGGAGAGCAACTCCCCGCCAGGAAGATGCGCGCCTCGATCGACGCTGCCCGCCACGCTGACGTGTGGATCGCCGTCGGCACTTCCGGGACGGTGTTTCCCGCCGCCGGGCTCATCGACTTCTGCCGTCCCGGCACGGTCCGGGTACTCGTCAACGCCCAACCATGGACCGACAACGCTTCGACGTTCGAGCGGGAAGTGCTCGGCGACGCCTCCACCGTTCTGGGTGATGTGCTCCGCGAACTGCACGCTGCTGCCCTCCGGTAGCTGAAGTCTTCTCGGCAACGTAACGGTTGCGGTGTGTGATCATGCCGGACGGCGGGATGGTGACTCGGCGTCAGACATGAGTGAAGCCCCTGGTAGGAACGTTCTGCGAAGATCACGTTCCGTACAACCAGAGGCTCCACGTGGCATCCAGTGTCACCTACACCGCCGTGCTCGATGTCCGCAGGGCAACCGCCGAGCACCTCGCGAAGCTGCTGTGCGGCCACCGCGAGCAGCCCGGGACCCGCAAGGGCACTCGCGTGCTGGGCGTCTTCAAACAGGCGGTGCTCGTGCTGCGCTGGTTCGTCGACGGTACCCGGCTGGTTCAACTCGCCAGGGACAACGGCATCTCGGTACCGACCTGTCGGGCTCGAAAAGTCATCGCTGCTGGTCAAGCGGCATAGCGGTATTCGTTAATGACGCCGCCGAGGACATGTGTACGTAGGAGTTTGTGCGCGTCGGGGTTGTGCACGGTGGTGGGCTGCTGGTGAGCGTCAGGAGGTAGCTGGCCTCGGCTTCGATGAGGGCGGTGTGTGTTGTAGTGCCGTTGGTAGGCGGCCAGGACTCGTCGGACGTGTGCCTCGTTCGTGATCAGGATGTGGTCGAGGGTTTCGCGCCGGATGCTGCCGATCACCCGTTCATAGTGGGCGTTCATTCTCGGTGTTCGTGGCGCGCTCTTGATCACCTCCATGCCATCGGCTTCGAAGACGGCGTCGAAGGACTGTCCGTACTTGCCGTCGCGGTCACGTAGCAGGAACCGCAGGGACTCCGTCCGCATGCCGAGGTCGGCGGCTGTGTTCCGGGCCTGCTGTACGGCCCATTCCTGGGTGGGATGGGCCGTGACGCCTGAGATGTGGAGGCGCCGGGTGCCGTGTTCGAGGAAGGCCAGCGCGTACAGTCGGCGTCCGCGCACGGTGTCGAGATGGAAGAAGTCTGCAGCGATGATGCCCTCGGCCTGGTTCGTGAGGAACTCGCGCCAGGTTGGGCCGGCGCGGCGTGGGGCCGGATCAATGCCCGCAGCGTTCAGGATCTCCCACACCGTGGATGCGGCGATCGGATGCCCGAGGCGAGCCAGCTCGCCCTGGATCCGCCTGTGGCCCCACCCTGTGTTCTCCCGGGCCAGTCGCAGTATCAGCTTCCTGAGCGCCGCCCTGGTCGGTGGTCGCCCGGTCCGAGCGCGCTGCGCGCTGTAGTCCCATTTCGCCGCGATGAACCTGCGATGCCAGGCCAGCAGGGTGCCGGGCGTGACCGGGAAGACCTCACGCCACCGGTAGCGGGGTATCAGGCCCGACAGCGCAGCCAGCCAGAACCGATCAAAGGGCTCATAGCGCACCCGGCCGTTGATCTGACGGCGCAGCACCGCGTTCTCGTGCCGCAACACGAGCAACTCCGCGTCCTTCGTGGCCTGGCTGCGCAGCAGTACCCGGGGGGATGGACAGCAGCTTGCGGGCGATCTTGTACACCAGTGAGACGGTCACGCGGACATGCTGCCAGCCGAGACCGAATACCTGACGTTACCTGCGGCGACGACTTTCCGAGCCCCACAGGATCGTGCAGCTCGGACGCAACCTCCTCATGGACCTCGAGGACGCGGGCAGCAAGGCGAAGTTCCTCATCCGCGATCGCGATTCCAAGTTCACAGTCGCCTTCGACGCCCTGATGACCGATGCCGGTCTCAAGGTCGTCACCACCGGCATTCGGATGCCGAGGATGAACTCGCTCATGGAGCGATGGATACAGACCTGCCGCACCGAACTCCTGGACCGGACCTTGATCTGGAACCAGCGACACCTTCCCCACGCCCTGCGCGAGTACGAATCCTTCTACAACGATCAACGCCCGCACAGGGCCCTGAAGCAAGCCGCCCCATGCCGCCCGCTACCCACACCCATCACCCAACAAGCCCAACTCGCCCACCTGGAAGTCAGCCGACGAGACCGACTCAGCGGAACCCTCCACGAATACCAGCACGCGGCGTGACCTGCACGGATGATTTATCGGCACCCGCAGTGCCGCAGTACGTGGCTCTCTACCTGCAACGAGACCACGAGAGGCGGACGTTCCGCTTCGAGCAGGCGCCGCTGCCTCTGCCTTCGATCGCGCAGTCCTGGCTGATCCATCGCGGCTGTCCGCCCGAGTCCATCGCACTCGACCCCGAATGGGGCACCGCGCCGGCCGACGAGGTGACGCGGGCCCTGGAGCAACGCCTCATGAGTGACGGGAACCACTATGCCCTCGGCTGGTCCTACACCCGGGACGACCCGGACGACTGGGTCACCCTCGCGACACTACGCGCCCTGGATGAGCGTGCCCCGTCCCCGTTCCGTGTCGTGGTCGAGGAAGCCGATATCGAGGCGGGAACGCACACACTGCGCGAGGGCGGCTTCGAAACGGTCCATGAAGCCCTGACGGGGTGCGACGACCGCCTCAGCGGCACGGGTAAGGTTCTCCCGCCGGTCCGCCCGACACCATCCCTTTCCCGCCCAGCTTCCGTGCCGAAACCGGTCGCTCCCCGCTCACCGGGACGTTCCCGCTAAAGCATTTACCACGCCCCCGGCGCGCACCAAAGGTGCGCTGGACTGCTGACCAGCCGTTCCCGGAAACCAGGAGCCGCCTTGCGCGGCCACGATTTGGATCGAGGCCTACGCCACGCGGCGCAACACACTCCTGAAACTGTCACTGTATGTAAGAATTGATGCATTGATGGACAAGGGGACGGCAGATTGACTCAACCATGACCGAATCCTGCCCGGAACAGCCGCCAGGTCCGGGCCCGAATGAACCCCTGCGGCTCAGTGCCGCCGGCGCGGCCGCATCAGCCTGGATCACTGTGTTGACCACCGAGCACTACAACATGCAGACGCAACGCGCCGCCACGATCAGCGAAGCCAACGGACGGGCCAGCATTTTCCTCGGCGCCTTGTCGGCCGGCCTCATTGCTCTCGGGTTCTACGGTCGCGCCGGGCACAGTGCAGGGACCACCACCTTTTACACGCTGGTACTGTCGTCGCTGGCGTTCTTGGGTGTGGTCACCTTCGTTCGCTGCCTGGAGATCTCCATTGACGACTGGCAGTTCAATATCCGTATCGCCAGACTGCGCGCCATGTACGCGGAACTGGTTCCCGAGCTGGCCGACCTGCTCCTCGCTGTGGCCGGTGCCGAGCAGGCCGTGGTCATGTTGACGCCGCACCGACAGCCATTTCAGCGGATGCTCAGCGTTGCGGGCAGTATTGGTGTGATCACGAGTGTCGTCATCGGTGCCGACGTCGGCGTCGTGGCCTACGGACTGCACGCCCCGCTCACCACAGCTCTTCCTGCGGGAGTAGCGGCCGGACTCGTTATGCTCGTCGCGAGCGTCCGCTTTCAAAGCTCGCGCTGGAAAGGGGTTTCTGCCGCCGACCCTTCTCGCGGCAGCATCTAGAGCACACCCGATGCAAAAAGATGAGCCTGAGTTGAGTTTTACCATCCTTTGACAGTGGCGTGCATTTCCCAGACGAGGATTTCGGCGGGTTCGTCGGCGGTGATCCGCTGGCCTCCGGTTGCAGTGAAGCGCACGGAATCCCCGGCTTCGAGTTTTCCGGATGCCTCCAGCGTGACGGTGCCGCGGGGAACGAAGAGGTGAAGGAACGGCGCCTCGGGAAGGAGCACCGAGTCGCCCGGGTTCAGTCGTGCCGCGTGCAGTCCGGCGTACTTGTTCTTGATGCGGATCGCCGATGCGTCGGCATGCCGGTCCATTCCCGAGGCCACGGTGACCAGGCCGCCGTGCAACAGTGCATCGTCGATCTCCAACTGTTCGTAGCCGGGAGTGATGCGCTCCTCGTCGGGCACGACCCACATCTGTACGAAGTGCACGGGGTCGGTGTGGGGGCTGACGCCCTCAACTCGCCAGGAGTCGTTCTTCTCCGAATGCAGGATGCCCGTCCCGGCGCTCATGCGCTGGGCGAGTCCGGGGTAGATCAGCCCGGTGTGGCCGGTGGAGTCCTGGTGGACCAGTGACCCCTGCAGCACCCACGTGACGATCTCCATGTCCTGGTGTGGATGCGTTTCGAAGCCGGTGCCGGCGGTGACGATGTCGTCGTTGTTAACCAGCAGCAGTCCATGGTGGGTGTTCTGAGGGTCGTAGTGGTGCGAGAAAGAGAAGGAGTGCTTGGAATCAAGCCAGGACAGCTCTGTTTTGTACCGTTCCCGGCTGCGGCGGATGTCCACCGTCGGTTGCAGAGCAGCGGTCATCGCATGCGTCCTCTCCACACCCGGCGTACCGCCGCGTTCACAGCCGTCCCCGGGCGCCGGGCGGAACCGTCACCGCCGGCACAGCGTCGGGGGCTCCCCGGTCGGCGACGTGCAGTTGCGTGCAGTGCTGGTCGGCGATCTCGGCGCAGATGTCGGCCGCCTGCTCGCAGAGGGGGTTGCCGAAGTCCGCGGCGGTCAACGCCATGATCATCTTGTAGCGGAGGTCATACATGTCCGCCTCCGGAAGTTCGGGGGGTCAGCAGCCTCCAGGCTAGGCGCACCCGCGTGCCGCCGCCATCCGGAAGTATGGGCGTGATCGTTGATCGTGGGTCTGAGACTGGTCTACCTGATCTTCTGTCGACTACTGGGCTGCCCCTCTTGCTGGGCCGATCGACCGCCGCGAACAACGTCGAGATCCTCGCTCCCCGCCATGAGGTCGCTGCGCTGCGTCGGCAGGTCGAGCGCCCGCGGATCTCGTGGGCCGATCGTGCCGTGCTCTCCGCTCTCGCACGGCAGCTGCCGCCCGTCTTGCGTCATCATCGGCTGGTGACCCCGGGGGCGCTGCTTGCCTGGCACCGCCGTCTGGTGCGCTGGAAGTGGCGTCAAGCACCGGTCAGAGCCGGTCGTCCGCCGTTGTCGGAAGAGACGGTCGCGCTCATCCAGCGCTTGGCGAGGGAGAATCCGACCTGGGGCTACGTCAGGATCCAGGGTGAGCTGCGACGGCTCGGTCATCGGGTCGCCGCCGCCACCGTCCGTCGCGTCCTGCGCCGTTCTGGTCTACCGCCCGCATTGCAGCGTGCATCCCAGCAGACCTGGCGCTCGTTCCTCCGCACCCAGGCCCGCACGCTGCTTGCCTGTGGCTTCATGCACGTGGAGACCGTCTTCCTCAAGCGTCTCTATGTCTTCTTCGTCATGGAGATCGCCACCCGGCGTGTCCATATCCTGGGCGTCACCGCCAGGGGCGGAACCGGTGGCAGGCGCGGGGATGCCGGGGGTGCAACGGCTGCAGTTCTTCCTGTCCGAGTCCCCCTGGGAGGTCGAGCAGGTCAACGACCGGCGGCTTGAACTGCTGCGTGAGGAGTCGGCGACGGCTCCGCGCGACGGCGGGGTCATCGTGATCGACGACTCCGGAGACCGCAAGGACGGCACGGCGACCGCGCACGTGGGCCGGCAGTGGCTGGGCCGGTTGGGAAAGACGGACAACGGCATCGTCACGGTGACCACGGTATGGACCGACGGCCGCGTGTACTACCCACTGCACGCGACTCCCTACACCCCCGCCCATCACTTCACCCGCGGCCGGTCCGATCCGGCCTTCCGCACGAAACCGCAGCCGGCCGCCCACCTCGCAGCCCGCGGGAAGGAAGCGGGCTTCAGCTGCCGGGCGGTGGTCGCCGACTGTGCCTACTCCGTCAGCGACGACTGGTACCTCGCGCTGCGCGAGGCCGGCCTGGCCTACGTGGTCGCCCTCAAGCCGCACCGCGGCACCTGGGCTCCGGTCGACCAGCCGCACACCCCCATCGAAGCCGCCCACGCCCTGACCTGGTGCGATGCCAAGTGTCCAGGCGACTGGACACCCGTGGAGCGTCACTTCCGCGACGGGCACACCGACACCTGGTGGGCCGCCGATGCCCGCCTGGGCGGCTACGGACCCGACTCACCCTGCCGCCTGATCGTGGCCACCACCGACCCAGCCGGACTCCCGGAGAAGGCCACCTGGTACCTGGCCACCAACCTGCCCCACCCCGACGCACCCCATGCCACCACCAGCCCGCACCCGCCGGCCGACCTCGCCGAGATCATTCGCCTCTACGGCCTGCGTCCGTGGATCGAGCAGAGCTACAAGCAGATCAAGGACGAACTCGGCTGGGCCGACTTCCAAGTCCGCTCCGACCGCGCCATCCGCCGCCACCAGACCCTGGTCAACTGCGCCTTCTCCTTCTGCTGGGACCAATGGTTCGCCCCACCCGGACCCCTGGATGCCACCGCGCCGGACCCGTGCCCCGACGAGAGGCCAGAGAGGGGGACCGGCCCCGTCCCACCAGCTCCAACCGCGTTGCTGGCCCCGGGCCTTACGAGCCATCCGTTCCTGGCTCACCCCCGCCATCACCCTCAACCGATGGTGGCGAGCCTGGACGGACACGGACCCACCCTCCGAGCTCCAGGCCCTGATCGACGCGGTCACCACCGGACACGGCATCGACCTCCACCTCCGGATTTAACGAACTACCGGTAAGGCGCACGGCCGGCGTGGCGGGGAGCGGCCGCCTTCTCGACCCGGCTGATATTCCCCGACACTCGGGAGAATGCGGCGAACGTGGTGTCTGACCAGTCAGGTTGCGAGCGTCCCGGGTCACGGCTGTGGGCCCTCAGGAACGGGTGACCGAGACAATCCACGAGCGCAGGCGTGTGATGTCCGCGAATGACGCGACAGTCTCCCGGTCGGATCCGGAGAGAACCCCTACCAGCACCTCATGACCGGTCCGGTTCCGGACCGTCGCCGGGCCGCCCGAATCGCCTCCCACGGGGAGGCCGTTCCCCCGCGCGGCGCAGAAGTCGTCCGCTCCTACCATGAGTTCGCACCGCCGGTCCGAGTGTGCCGCGACCTTCAACTGCGCCTGCTTGAGCACATTGGACTGGCATGAGGACTCAGGCTTCGGGGGAGCGCACGTGGCCCCCCAACCGTATGCGCGAACACTCCGGCCCACCTTCACGTCTCCGCTGCGCCCCAGCTCGATCGGCTTGACCTTGAGTCGGGGAACCTTCACGAGTGCCACGTCGGCTTTGGGAGTGAACAGGGTGGCGTTCTCGATCCGGCGCACGATGGTGCCGTGCCGCTGGTCGAGGCTGCCGACCCGCAAGGTGATGCGCCAATTGTCGTATCGGACGCAGTGGCCGGCAGTGAGCACCCACTCGGGGTCGACCACCGTACCTGTGCACGAGGGGTCGCCGTCGGCGTAGACACGGACGGCCCACGGGCCGTGCTTGCTGACGGACCCGCCCTGGATTGCCCAGGCCGATTCGGGCAATGCCAGGACGGCGAGGAGCATGGTGAGTATTGCGCCCACTCCACATAGTTTGATCAAGATGCATACCCCTTGGCCGGTGTGCCCGCTGGTCGGTGAGTCTCACCCACCCCGTGAAGAGTCGTGGTTGGGCCTCGGGGTTCCCTGAGAACACGCCGTCTCAGGTGGCGTTCCACAGGCATCGGTAGAAGTCGATCCGTTGCGGTCGGGACCGATGCCGTAGGCGTCAAGGAGGGCGTCCGCCCAACCCGGCCCGTAGCTCAAGTCGGCACTCCAGGCGGCGCGGCCAGATCCGCCCACCGGTCGGCGACGCCGAGGGCTCCCAGGTCCACGTGAGCGGACCACGAACCTTCCTCGGGCAGGAGCGTGTTGGGGGCGCAGGGGTCGCCGTGGCACACGACGAGGTGGTCGACCGGCGGCGCCTCGGGTAGGTCTGCGGGCACCTCGATGCCCGCGCGCCGGGCGATGCCCAAACGGTGGTCGACCGACCAGCTGAAGGGGCAGTCGGCCACGGGCAGCTGCTCGTGCAGGGCCCGGAGCGCGGTGTGCCGATCGAGTCGTGGGGGCCGTTCGCCGAAGGCCGGAACAACCTCTTCACGCACCCGGTCCTGAGCGACATCGCTGGCGAGCACGGGAAGTCCGTGGCACAGGTGGTGCTCCGCTGGCTCGTCCAGCTGGAGGTCGTCGTGATCCCGAAGTCGGTCCGCGCCGACCAGGGTGGAGAACATCGACATCTTCGACTTCGTGTGGGGTTCCAGAACTCGGCCCGGCGCGATGACCAGCGGTAATGAGTGGAGTAGCACTCGCTGGGAAGGACTCGGATTGTGCCGCTACGTCTGCTCTACTTGATCTTCACCCGGCTGCTCGGCTGGTGCGTGCTCCTCTGCAGTTCCTCCACCTCCAAGGACATCGAGCTGCTCGTTCTGCGGCACGAGGTGGCGGTGCTGCGCCGCACGAACCCCAAGCCGCGCTTTACCTGGGCCGACCGCGCGTACCTCGCCGCGCTGGTCCGGCAGCTGCCGCGGCGACTGCGACGGCACCGTCTGGTCACACCCGACACGATTCTGCGGTGGCACCGCCGACTGGTGACGAAGAAGTGGACGTACCCGAACCGAACCGGCCGCCCGCCGATCGACCAGGCGATCGCCACGCTCATCGAACAACTCGCCCGGGAGAACACCTCGTGGGGATACAAGCGCATCCAGGGCGAGCTGCTCAAGCTCGGCCACCGCGTGGGCGCCTCCACCATCCGCAGAGTCCTCAAACGCCGGAAGACACCCCCGGCACCTGAACGGCAGACCGACACAACGTGGCGGCACTTCCTCCGCACCCAGGCCCAGGCCACACTCGCCGTCGACTTCTTCCACGTGGACTGCGCCGTCACCCTGCGGCGGCTGTATGTGCTCTTTGTGATGGAAGTCGGCACCCGGTACGTGCACGTCCTCGGAGTGACCGGCCATCCGGACGGCCCCTGGACCACGCAACAGGCCCGCCATCTCCTGATGGACCTCGGCCACCGCGCATCCGAGTTCGACTTCCTCATACGCGACCGGGCCAGCCAGTTCAGCAGGTCGTTCGACATGGTCCTCGCCAGCGAGGGCATCAAAGCCGTAAAGATCCCTCCGCGGTGCCCCCAAGCGAATGCATACGCGGAGAGATTCGTACGCACCGTCCGTTCAGAGGTCACCGACCGGATCCTCATCTTCGGCCGACGCCACCTACGCGCCGTGCTGAACGAGTACATCCAGCACTACAACGAACGAAGACCCCACCGCGGACAACAACTCCACCCGCCACGGCCCGACCACCCCATCGCCGATCCTTCCCACGAGCGGATCAAGCGCCGACAGCGCCTCGGCGGCCTCATCAACGAATACGAACGAGCGGCGTAG

Protein sequences of DBSCAN-SWA_3

>NC_016582|1637303:1727625|1676310_1677378_-|WP_014173797.1|DBSCAN-SWA
MSNALWNPTVAGEITLPHRLAMAPLTRSRATPDGVPTELNAEYYAQRASHALIITEGTQPSADGQGYPVTPGIYTEEHIAGWRKVADAVHGADGRIVIQLMHAGRIAHPDNTPHRRQPVAPSAIKPAGQTFTVSGLQEMPEPRELSTEEVAATVDDFRRAAAAAIAAGADGVEIHGANGYLVNQFLFPSANQRTDQYGGSLDNRIRFAVEVATAVADEIGAGRTGIRISPGNPFQLNDLVESDPHELYPHLLRALAPLNLAYLHVGHGGDEELLFTLRKLWPTTLFLNRAGADIPTRVKDIEDGLADVITVGTMALANPDLVERVRAGAPLNTPDPNTFYGGGAAGYTDYPTYEA
>NC_016582|1637303:1727625|1688719_1689418_-|WP_014173808.1|DBSCAN-SWA
MNLSTSTALVTGANRGFGRALAAELLGRGATVYAGARNPGQVDLPGAKPIPLDITDPASVAAAAEATGDVTVLINNAGSATGSDLLEANLDDIRLEMDTHYFGTLSMARSFAPQIAANGGGAILNVLSGLSWVSFPEIGAYCAAKSAEWSLTNALRVQLADQGIQVAGLHVGYMDTDMVRAVDAAKSDPADIARIAVDGIAAGAYEILADNAARQAQAALSGGVSVLYPQLP
>NC_016582|1637303:1727625|1653717_1654050_-|WP_014173768.1|DBSCAN-SWA
MLLRLAYLGVTNAFALLRLLPMSDRNKDAEILAIRHQITVLERQLGGARVRFTPGDRAFLAALLHRLPLPALRRVRLLVRPDTVLRWHRDLSRRRHCRCRILRPCRSRTR
>NC_016582|1637303:1727625|1707755_1708178_-|WP_014173830.1|DBSCAN-SWA
MQKYTVVQRITRFFWIPRGASRKQPTPCWRVIGLCLSVLAFGAGVTAVGWDDEFGGSYIMAMMLLLNVVDDIIEGVRHRWPAALAAVAILSGASWLTSAVLPGSLGAAWAKTIAAAVGVTLGFAVAAAITRLPERLAAAR
>NC_016582|1637303:1727625|1694693_1695107_+|WP_014173813.1|DBSCAN-SWA
MGTTDDLRFYGGADAYLAACPSRQILDVLANKWTMLVMGALSGGPMRFGELRRRLDGITQKMLTQTLRTLERDGLVTRTVFPTIPPKVEYAATGLGESVTALMHAIRAWSEENINAVLNARDTYDARAAQEVQPVTT
>NC_016582|1637303:1727625|1726557_1727625_+|WP_014173856.1|transposase|DBSCAN-SWA
MPLRLLYLIFTRLLGWCVLLCSSSTSKDIELLVLRHEVAVLRRTNPKPRFTWADRAYLAALVRQLPRRLRRHRLVTPDTILRWHRRLVTKKWTYPNRTGRPPIDQAIATLIEQLARENTSWGYKRIQGELLKLGHRVGASTIRRVLKRRKTPPAPERQTDTTWRHFLRTQAQATLAVDFFHVDCAVTLRRLYVLFVMEVGTRYVHVLGVTGHPDGPWTTQQARHLLMDLGHRASEFDFLIRDRASQFSRSFDMVLASEGIKAVKIPPRCPQANAYAERFVRTVRSEVTDRILIFGRRHLRAVLNEYIQHYNERRPHRGQQLHPPRPDHPIADPSHERIKRRQRLGGLINEYERAA
>NC_016582|1637303:1727625|1720486_1721014_+|WP_014173848.1|DBSCAN-SWA
MPQYVALYLQRDHERRTFRFEQAPLPLPSIAQSWLIHRGCPPESIALDPEWGTAPADEVTRALEQRLMSDGNHYALGWSYTRDDPDDWVTLATLRALDERAPSPFRVVVEEADIEAGTHTLREGGFETVHEALTGCDDRLSGTGKVLPPVRPTPSLSRPASVPKPVAPRSPGRSR
>NC_016582|1637303:1727625|1667869_1668994_+|WP_143675893.1|DBSCAN-SWA
MTRSDDYSSPAGKTALRKGAATGPDGASASAVLDVPLPVNDCTGDEDGYWYATRTMQCQIDPNVKYSYYSSDNKLLGTALFATAQQLDLATKSLQRTETDQITMLSSTGTLPAGLSVSWTTSCSSPCAPGTTKLWTSAPISLGQNLKKTYTLTDQPSTGYDYIDLDYQLSIGSPDAIDLLPPITWGGAEVRCDNKISVADKAGCVVPWYTPTLQIPRSQYGSSADMLEWAQNNLSGHWGLRGTGQPLHRLKNSSQQASNRQAICGTSKFTKDPNVQDDTCDEFPFAGTYESGALNSVDHGKDCAQVTAVRADTSGNLAVDWPTVTPTGTVSGSEKCVRGHIPGALNSDVGSAYGVFVKDKLLADNDPFWLRITF
>NC_016582|1637303:1727625|1722744_1722939_-|WP_014173851.1|DBSCAN-SWA
MYDLRYKMIMALTAADFGNPLCEQAADICAEIADQHCTQLHVADRGAPDAVPAVTVPPGARGRL
>NC_016582|1637303:1727625|1709171_1709414_+|WP_193383691.1|DBSCAN-SWA
MTAHQPSVHAEVLAERAVRRDGREPLGLAAAISLMMTERGMVAPAAGGNVLALLCTKSALRLPDRLPLDAAADGEGRQAE
>NC_016582|1637303:1727625|1702257_1702704_+|WP_014173823.1|DBSCAN-SWA
MEALREAICELVAAAQPCSVRHVYYLGIGPLWDKDTGHSRRDYSVVVREVGHLRETGRLPWGWITDGTRMVRQETQYDSLDDAMQRNTETYRRNLWASQSRRVEVWCESDSVGGVLLPVTSAWGVGLYSCRGQSSKTFVYEAVRFGRG
>NC_016582|1637303:1727625|1675310_1675883_-|WP_014173796.1|DBSCAN-SWA
MVRYAKEHKQVTRQRIIEKAGHRFKQDGIDGSGISTLMSDAGLTNGAFYAHFASKDDLVAHVMADQLRTQVARYGTLRPGRQGLEDLVREYLSPEHRDHPGDGCPSAALLDEIGRCGDGPKQAYTDGARDIVEEIAARLAPENPQSARGKAIGLFTMMVGALQLSRALSDRKFADEVLEQGIESALTFMR
>NC_016582|1637303:1727625|1657936_1658719_+|WP_014173773.1|DBSCAN-SWA
MNGTVTVIEKGAVRVHSYMAPDDSLNVTTQLIETPARIVAVDAQYALGYADEVVAYAKGLGKPIDRLIVTHAHPDHFHGAARFGAPVHALPAVRDQIVAQGDAQDPTGTLVPVTDVTPTVEISPGTEVIDGVPFVFEALTGGEAADELVIRLPEQGVLVAQDLVYHATHLFLGNNDIDGWQRALDALAADTSYDTILAGHGLPATPAVYTELRGYLAAARELLGDDGEAYKKAILERYPSYGGPFLIDIGNQYLFGAQGA
>NC_016582|1637303:1727625|1705213_1706599_-|WP_106436540.1|DBSCAN-SWA
MRARLNAVRHHQLFFMGLHYRRGSAPVVARRGGGRGAVRKPPPAPAWRPSADWRQLPLFGQVPRDYGRLDPADADLASPWLAWAKYLAYQLAEARGWGRGIRFAVNRGLALVLTGYVEGDVIRHTEIFAPLRALDLRFGHVVTVLEEMGIFEDDSEPSFEGWLAERLEGLAPAIRSETERWTRVLRDGGPRSLPRREGTVWLYLNRVRPALLEWSNRYDHLREVTRDDVLAYLKTLHGRQRHDQLVALRSLFIWAKRNGLIFRNPTIRIKVGQYEYAVLQPLAPAEVDRSVAAATTPATRLILALAAVHAARVAQIGTLMLDDVDLGNRRLTIAGRVRPLDDLTLKLLLEWLEHRRNRWPNTANLHLLINNQTATKTSRASNHWISASMRGQDATLERLRVDRQLEEALTHGPDPLHLAEVFGLDEKTAMRYADSARSLLEQAAEQQLRRNQLDRDIPRRE
>NC_016582|1637303:1727625|1716366_1716795_+|WP_014173842.1|DBSCAN-SWA
MVAALGPDAGSTSGFTWPDRYLTDPEVALCIGLSGTHVLFWNPFASGWFCDRVDSEDHMLDQAHQLIEGAVVPRPDGVVAAARLQYLVRLDELPLRAAETVVPAGTRLTPAQQVAVDRGALTEDVARRLAVYAAEEATLART
>NC_016582|1637303:1727625|1716865_1717474_-|WP_014173843.1|DBSCAN-SWA
MIHRRRARRISGHSPSAIRSNGPACGVFATRLGGELAEPDQAFNALIRGVHAVAERANALHVVEAAQSMIANAAKQLRDKSSPDRARVVFIVSHFLDRPYVECLDLVIAHALTAPTLPDEIDAMWVFFAPSHLVVWSAVEQRWTQLLLGSFKEEGTAPEVDFGMEPLQHYEGLFLEPAGIDGPSPFYYGLGTGELASAVDAE
>NC_016582|1637303:1727625|1693651_1694593_-|WP_014173812.1|DBSCAN-SWA
MRAITQMTFGGPEVLELVDDAPKPAPGPTQVLVRVKATSVNPVELFVRSGAFPLLGEPPFVLGWDMSGVVEQVDPGVHRFKVGDEVYGMPYFPAAAGANAEYLVAPARQLARKPAGIGHEEAAALPLVGLTAWHALVEIAQLRSGQRALIHGAGGGLGHVAVQLAKHLGAEVVGTASAGKHDFLRGLGADQLIDYRTQDYTEVLRDAPVDVVLETLGGGNAERSFGVLRQGGVLVTAVERLSTTLPELAEQSGVRFAAVGVEPDPAGLEALTELVEAGRMRVHLQQVFPLERLAEAHEVLAAGGVQGKLAITV
>NC_016582|1637303:1727625|1672385_1672601_-|WP_014173790.1|DBSCAN-SWA
MWNILKDHSIDPAPERQRTTRATFLRSQTILSADFFETETLTGATLYVLAVIEHATRRVLILDTTAHPTAA
>NC_016582|1637303:1727625|1665979_1666549_-|WP_078610329.1|transposase|DBSCAN-SWA
MKTYGIALITPVLLDTSRQAKAQADFAATDFTIDWEAGKATCPAGHTSATWNPVVSEGIPKTVVTFAALDRIPCPFKPQCTTAKKNRRQLSLHPRQMTETLRHTPSPAEDQGLEHRLRPTRRHRGHHPAGHRCHRHTPHTLPRPGEDPPRTHLLRRRTQPDPPECLVNDRPLDRTRTSHLTRLEHTLTA
>NC_016582|1637303:1727625|1703390_1704293_+|WP_014173825.1|DBSCAN-SWA
MAPDTVSLRYFLVLAQELNFTRAAARIGIAQPALSARMRRLEAELGTALLVRNTRSVVLTTAGAALAESAPPALAALDRAWDTAQSAAAGELGTLRIGYSLSAGAETAPALVDRLIRGNSGLEVGAVPMATPEISPAVADGRIDAGITRGEQPGRGVRRFLLRRERVGVQLAQHHPLAEHPEIEIADAAAYPLRLPDRAANPVIHDQLSALFRDTRPHPRFHTPAVSFDMSQRDLRDGVTLAPAGEAAVTAQPAGLTWRPLRGAPSLTIHLVLPREQSPLHRRIRAVAKTLAHELHWLPD
>NC_016582|1637303:1727625|1662620_1665383_-|WP_106436539.1|DBSCAN-SWA
MAHLTGPWAGAGLRLLAVDSLPATQARQWEDRVVRHPTSPVDRMLDGKCRWRPIRTRDSGRDPGTDPLPEHSGSAAVSGIVVVPMVSQERVLGTLSVICLEEEPTAEECSFLEEVAHLVARHLGRSLTAPRGASSEWWLEQDGGSRLSEAAKAVSVGSWDWNIRTGELLYDEQAMRVLGIDPDTYDRRIESWVDMVHPDDLPWVMAGTDEAIRTRSLYRVEYRIRRPDGTSGWAQARGRVIIGPDGEPAHMVGTVWDTTHTRAARDAVDHALWHMTDGFAAVDADWRITFANPEAERALGPVPDTGDRSLWAIPAAQTPGFKEMCRRTISEGRPVSTELCSSANQRWYGLRLVPVPQGLTIYSTDITDRKIRNAEREAAERSAAERSARIARLTGALAEAITMRDVVEATAEHVLAPFGATRLAVLTMEDRSPRVVGSIGYGETQLDVFRAHGPPFTAPVAEVLTTRVPLFITSTEEHRARYPLSAEVLVTDEDQSWAFLPLIVSGQVTGCCVIDFAGRQPLSGEERTLLTALSGFIAQALERARLYDSEHNRAQELQRGLLPQKLPPLLAIGAAARYLPADRRLDVGGDWYDLIELSAERAALVIGDVMGHGLSEAATMGRLRTAVRTLAELELPPDEILTHLNDLVSDLSDDSYATCLYAVYDPTTCLCEFASAGHLPPVVIHPDHTVHIPEVPTNSPLGAATPPFDVVQIEVPANSLLALFTDGLVESPGQDIDECVDRFTGILDAAIGKEDQPSLETLCDTIVSALLPTQKKGRDDAALFLARAHALTAENVAVWPLPTAPTAAHRARELVRGQLPLWHLDDLVMTTELVVSELLGNVVRHARGPVALRLLRGRSLFCEVSDGSLTTPHIRRASDTDEDGRGLQLISALTHRWGVRYGASGKTIWTEQLLHTLPAI
>NC_016582|1637303:1727625|1685737_1685881_-|WP_158104654.1|DBSCAN-SWA
MTFDICGMTRAFHQEHLDAALASSPVLSKLANITRRWIGVPPKLVNN
>NC_016582|1637303:1727625|1671448_1672330_+|WP_014173789.1|DBSCAN-SWA
METSDATCIHSEEAMVFGRDTRLFAGAVIVACMVLVGPSAPSGAPLARSLPVDAVRGVVPNRVMTWNICNPCEESNVDRAAEIATYAPQVIGLQEACVRDVERMRDYLEGFYGLVYHVEYGMVLRNWGRCGGAPWSPGAFGQAVLSAAPMTNPVNVEYPDGGSEDRGYMAVTTSVGGRFVRVFNTHLAERRQEAVRADQTDVLAADVARHDRAIVLGDFNAVPDAPELTGMWALAADTDPQCHPSSTGTCKPTTDWQSKFDYIFLRGIVPLEHRVLPTPYSDHHLLHTDLDPT
>NC_016582|1637303:1727625|1690896_1692498_-|WP_014173810.1|transposase|DBSCAN-SWA
MGGTSDVFAPGHLGELTQVVPPELIDAVLEETGARERRLRCLPSRVGVYFVLALGLFEHLGARLVWTKLAAGLTARVPEPSEKALRDLRRRIGPAPVKRLFEVLAGPLAQPSTPGVSYRRWRTVAFDGCSSLIVPDHERNWSWLGRPASRLGQAGYPRLMLMTLCETGTRGLIAAAFGPVARGETYYAQQLTSNLTPDMLLLADRAFHTNDLLAQAARRGAQFLVRCTSRRHPPTLTLLPDGSYLTRIAGLTLRVIEAEIRTRTVDGSTFGETYRLLTTLTDHRTDPAHQLVRLYHERWEIECAYLALRHTLLKGRVLRSKDPAGLTQELWGLLTLYQALRSVMVTAVETQPGTDPDRAAFIIALEAARDTIALTAHPTAIPGHDAQADLVGHIGTRLLHALLPKRRPRTSARVAKRGISRYHTWNRDQRPRGSTPIAAIDITVQAPVLPTAQDPDRKASSPWDRLCQILAAHANQPMHAHDLADHMGLTAPQSRKNLASQLCLWTRHSRLTRTAPNTYKITLPDTLTPAPGP
>NC_016582|1637303:1727625|1725076_1725757_-|WP_014173853.1|DBSCAN-SWA
MLLAVLALPESAWAIQGGSVSKHGPWAVRVYADGDPSCTGTVVDPEWVLTAGHCVRYDNWRITLRVGSLDQRHGTIVRRIENATLFTPKADVALVKVPRLKVKPIELGRSGDVKVGRSVRAYGWGATCAPPKPESSCQSNVLKQAQLKVAAHSDRRCELMVGADDFCAARGNGLPVGGDSGGPATVRNRTGHEVLVGVLSGSDRETVASFADITRLRSWIVSVTRS
>NC_016582|1637303:1727625|1700033_1700468_-|WP_014173819.1|transposase|DBSCAN-SWA
MDLGDSAGYFRFLIRDRDSKFTTAFDAVFASNGTAVIPTPPQSPRSNPFAERWIRTARTECTDRLLITGERHLRTVLNQYAEHYNTGRAHRSLDLHAPDDDPNVIPLPAAAVRRRQVLGGLINEYHTMSPQLPHHPHETPSSAA
>NC_016582|1637303:1727625|1689976_1690486_-|WP_106436306.1|DBSCAN-SWA
MIIAVAGVAGTLGGSFLTQRASERAKRREIELLRDQEEVRENLLLRRTCYMELNRDARQFTTALNRHLHVMRARSVEQTDSEALDEAKGAHRDRYSEAQMIAPDEVLARASEVNQALNKVYGQVKRLERQEPEPGETVATAIQAQAEIWDMLRAMRAAMRHDLGVTAQE
>NC_016582|1637303:1727625|1721211_1721898_+|WP_143675752.1|DBSCAN-SWA
MTESCPEQPPGPGPNEPLRLSAAGAAASAWITVLTTEHYNMQTQRAATISEANGRASIFLGALSAGLIALGFYGRAGHSAGTTTFYTLVLSSLAFLGVVTFVRCLEISIDDWQFNIRIARLRAMYAELVPELADLLLAVAGAEQAVVMLTPHRQPFQRMLSVAGSIGVITSVVIGADVGVVAYGLHAPLTTALPAGVAAGLVMLVASVRFQSSRWKGVSAADPSRGSI
>NC_016582|1637303:1727625|1647267_1648221_-|WP_143675894.1|DBSCAN-SWA
MANNNRPVSGKNLKAGPPGTKDSAGVWQVNRTDVTLSNTVTVTDADGDDADLSFQVYTTDANGNPKDQVQLTDPETGNPASYGVVVSDFVASGGTAQVTLRYGDLKTNTTYAFRTSAFDGSLYETEWSAWAKFHTRGRQLSITLPEPDKNAPTVDLDSYQEYQTARRNMPEPSASSTTSAPDKPTGQCSDIGNDKIGCIAIGKPGDLTAEQQASVAKRMHATMAGDDLVSWCSNLSAGADYFKRTEACMKKATPIHSYTYSKLPSGETILVGEATFASEIQLKLDTSSTAVQTSTRCGRPWPPCSSTSVCRCHASRS
>NC_016582|1637303:1727625|1680064_1680976_-|WP_014173799.1|DBSCAN-SWA
MGASPEAQQFAQFLESVSARSSTPGLDLAVIRDIVETNHRASAEPEGVTYAEVDTDGVPALWCIPEDAHPDRALLHFHFGGSVTASMHSDRKAAGHIAKAAGARSLVVNFRLAPEHPHPAQLDDAETAYRWLLSQGYEPRNIGSTGHSIGGTLAVMLPLRLLAKGEATPGAIASVSPWTDLTLQNAAVDKNEENDKMLSRNTLELFRGAWLQEPGVDFADPQISLVNADLTGLPPTIVHYGEYETLADDGAQLGLRLADFNVTSQVHPLPEGQHSFVLGAGRVPEVDQAIQQMGQWLRRHLGA
>NC_016582|1637303:1727625|1706838_1707168_-|WP_014173828.1|DBSCAN-SWA
MRWNLRLTAANKGIWKASELQRSLAEHGLVISAGKMSGLWSGQPVSLKLDDLDVICVVLGCEISDLLIPEPQKVTRPGEENITRTAVGAAAPVPVVVPKRRDGRSLPPA
>NC_016582|1637303:1727625|1695306_1696908_-|WP_043486181.1|transposase|DBSCAN-SWA
MDEAVRVADLLFPGVDVEVDRLVLTDLEVCVAVRSRAVSAACPECEQRSSRVHCYYERCLADRPVVGRRVRIGLRARRLVCENASCAHRTFTEQIPGPTRHHARRTQSLTTLLTDVALFLGARPGTRLSKRMSITTCNDTLLRQLRALPDPEPGPVPVLGVDEFALRRRRTYATILINMTTRRPVDVLADRRAETFAAWLRGHPEVRVICRDRAGPFRDGACAGAPQARQVADIWHLMHNLAEAVERIVGRHRAQSCEPLAVPVGTPPAAAAAQRELDIHGRPRPLVSRTRERYQQIHERMEPGDSMRAVARELGLSRGTVARFARTADVEELLAAATHRPSLMDDYRLYLHHRWLESCTNASALAREIQQLGYRGDVNTVRRHLRPYRTGAIPAQAPLPLRTVRRVTDWIMRRPEHLTDTERKLLTDLCERCPALASTTEYARRLAALLRDHRNEHLAFEVWLADVRLDGPHELQALGRGMRRNQAAILSALNTTHSSGPVEGNVTRIKLLKRQMYGRANFDLLRRRILLSP
>NC_016582|1637303:1727625|1701251_1701581_+|WP_014173820.1|DBSCAN-SWA
MGCDHFSTDVSYLPDLRTYLDDLLLQREKLRSMAEADDWARAEAMPSDAEITRIRRLIQRVTEDVETLTEAERAEIQRAAQVVRRMRQNFLGMPRIRQPLPDLRPERPA
>NC_016582|1637303:1727625|1637303_1638401_-|WP_014173751.1|transposase|DBSCAN-SWA
MLLRLAYLGVTNTFAMLRLLPMTDRDKDAEILALRHQITVLERQLGKEKIRFTPSDRAFLAALLHRLPLHVLRQLRLLVRPDTVLRWHRNLVKRRHAASCRPKRPGRPRTVRSIRILVLRLAKENPSWGYRRVHGELLVLGVKVGASTVWEILKEAGIDPAPERNSSTWATFLRSQADALLACDFMETVTLSGMRMYVLVVIEHDSRRIRILGATTHPIASWVAQAAKNLVMDLEDLGCRAQFMIRDRDGKFPELFDAVLKDAGIDVVLSGIQMPRMNSITERWIQTCRRELLDRTLIWNQQHLLHALREFEQFYNEHRPHQGIANARPLHPLPPPIHDPDTLARLDIRRHDRLGGILHEYRHAA
>NC_016582|1637303:1727625|1666787_1667873_+|WP_043486173.1|transposase|DBSCAN-SWA
MVVSLLYRMTRRLLSVPPVLLQRDTSKEAELLVLRHENAVLRRQLQGWARYEPADRLWFAALSSLIPRRRRAKVFPVTPSTRLAWHRNLVARRWDYSRRRRGPGRPPTQAAVKNLVLRLARENSRWGHRRIQGELARLGHPIAASTVWQILHTAGIDPAPRRTGPTWCEFLSAQATSLIACDFLHIDTISLQRLHALVFLEHRTRRLHIAGVTAHPTAAWATQQARNLATDLGIRMDSLRFLIRDRDSKYTDAFDAVFQAEDIEIVKTPVRAPKANAHCERVIGTLRREVLDHILILGEGHVRRVLATYQRHCNAHRPHRARCQLPPQAHGQPPPVLKPASRKVLRTRVLGGVINEYRYAS
>NC_016582|1637303:1727625|1709856_1710405_-|WP_014173834.1|DBSCAN-SWA
MPAPGTSTKSDERRRTIMAAAVDCFAQKGFYGTTTHEIAQWAGISQPYLYRLYPNKEALFAAAVDHVSVVMTETLVAHSPASGGAKPAPEAALDAARGAYSALVADRNILRFLMHANCAAGEPLVAQAVRRCYAKQVDTVRQLLGDDDAVRRWFGAGMLDNVAAVLGLADIDEPWAHVLTAR
>NC_016582|1637303:1727625|1669028_1669613_-|WP_086860112.1|DBSCAN-SWA
MTESALVGCVPWDHFGITCVRGLSPDEVLSRLSVTDQAPYPLCTPDEALQRFGSGAETPAARVCRSGEWTFLIDVDDHGVLLQSLVLTRLSMSTEAVSIWKLLDSTTRIAHAQSGELLAYYDAWHFQPAEGADPSFLNRALTDAGFFLEENWESDDWEPSVSALLMLEREFGLALSSEVAKSPLPTVSLLHLQG
>NC_016582|1637303:1727625|1697357_1697981_-|WP_043486183.1|DBSCAN-SWA
MPTHVPVFIATTLLLAMLPGASTAMMIRQVLEGGQRTVRGTLAGNATGFLLWSTAAAAGLSAVLLASPRAYAVLRIAGGIVLMILGVNTLRTALTTVSTRPPREGGRRTGFAGGYLTGLSTNLGNPKAGVFAVSVLPQFVTAKGPVFLSTVALGALWALVSASWYLLLTWAVGRGRALVSRPTVLRGLSVTTGVVLLGLGAAVAAGV
>NC_016582|1637303:1727625|1670248_1671346_+|WP_014173788.1|transposase|DBSCAN-SWA
MLLRLAYLGVTNAFVLLRLLPMSDRDKDAEILALRHQITVLERQLDGARLRFTPSDRVFLAALLHRLPLPALRRVRLLVRPDTVLRWHRDLARRRHAALSRPKRPGRPRTVRSIRILVLRLARENPSWGYRRLHGELLVLGVKVAASTVWKILKESGVDPAPGRSSSTWAGFLRSQADALLACDFFETVTFSGARMYVLAVIEHSSRRIRILGATAHPTTSWVTQAARNLVMDLEDVGCRARFMIRDRDGKFPVLFDAVLKGAGIEVVLTGIQMPRVNSIMERWVQTCRHELLDRTLIWNQRHLLHALREFEQFYNSHRPHQGIANARPLHPLPSPIDDPDKLSHLDIRRHDRLGGILHEYRHAA
>NC_016582|1637303:1727625|1698090_1699065_+|WP_014173817.1|DBSCAN-SWA
MVVDPGQLRLLVLIERHGSLTAAAHALQLTPAAVTQQVVKAERDWQVPLVIRGPRGATLTAAGALLASHGRTVEEASDKAEAQLAALLGHLSLRLRIGTFQAAALHLLPPALTALRHRHPDADVSVVDVVSGRGADEISAGRLDLAIVASWGTPLAPPPHLRAHPLLMDPMVVVLPDDHPLATGQPADSELRLKQLRDESWVSILAGHAAREQFHDAAREAGFTPTVRFETESYDVVQALVGTGSAVALVSRLALTRAPGTTHRELARPRPYRQLYALTKADASLTPLADMLIDLLRDVARDITATWEAPLQEEQRSSDSPHGG
>NC_016582|1637303:1727625|1669752_1670037_-|WP_143675892.1|DBSCAN-SWA
MEPDAPAATLDGQSRHGTGIPGSQSSTTSPSPLGRIEANARSANFAIALRAPGGANALISERISASSVSIESMPRSSLQPGILQAAIAVLTNMP
>NC_016582|1637303:1727625|1702908_1703202_-|WP_014173824.1|DBSCAN-SWA
MAKGYWVSVYPAISDPERLTAYDKLARPAVQAGGGRLLSRGGRVVAHEAGITQRVVLIEFDSFEQAVAAYESEAYQKALAALPDGVERDFRIIEGID
>NC_016582|1637303:1727625|1712646_1713594_-|WP_055413852.1|DBSCAN-SWA
MNERQLQILRELGELGSVTATAEALLMTPSAISQQLRLLQRSIPVPLTERDGRRLVLTDAGQALASAAIEVETALARARHTIEEFVDRPDAGVSVAAFHSAAAAFFPLLLLAQAGPGRPQLSLADEDVAQDHFPRLTRDYDLVLAHRLDQAPPWPTTVTASTLLREPLDIALPADHPLAAKRRLTPRDVADQPWITVHDGFPLMATIDAIATAANRRLNIVHRINEFAVVAEAVAAGGGLALMPRWTTRPHPALILRPLSGVHTRRHIDVLHRPERAARRAVRTVLTELHHAAATVQSRDVGAGAHAHETLAVDA
>NC_016582|1637303:1727625|1642098_1645422_+|WP_014173755.1|DBSCAN-SWA
MKRACAATIATAAAVALAAGMTSPASAEPERTAGDQAVQTTPKHRVTLITGDRVVVDAKGRVIGLERAKGREGIPVQIRKADGHTLVVPADAARLIADGRLDQRLFDVTELNKSANRKAQKQGLKLIVGYSGTAAAAKADVREAGDTKVRRTLKSLNADAVLTPKGDAPDLWAAVTDTPSGGAKTASGIAHVWLDGVRKASLDKSVPQIGADKAWAAGYNGKGVKIAVLDTGVDATHPDLKEQVVGEKNFSTSPDATDKYGHGTHVASIAAGTGAKSAGKYKGVAPGAKLLNGKVLGDDGSGDDSGILAGMEWAVEQGADVVNLSLGGGDTPDIDPLEAQVNKLSKEKGVLFAIAAGNDGDFGEQTIGSPGSAEAALTVGAVDDTDKLASFSSTGPGLDGQIKPDVTAPGVDTTAASAPGSVIAQEVGEKPPGYVSISGTSMATPHVAGAAAILKQQHPDWTYTQLKGALTGSAKGGKYTPFQQGSGRIQVDKAIKQTVVADPTSVSFGLQQWPHTDDKPVTDKVTYKNLGKTDVTLTLAVTATDPKGQAAPAGFFTLGTKTLTVPAGGSASADLTVNTKQGGTLDGAYSAYVTATGGGQSVRTAATVQREVESYDVTLKFIDRDGNPAKYYNAELDGVTGLAQGKWYSPYDESGTVKVRFPKGGYIFNSAVHVDPDDPAKGFDWVTQPKLSITKKATITVDARTAKPVDITVPDAAAKSEVATPLYTVGVPDGSNSYGWWLDSYANFRTAHAGPQITDGSLYQQWGGHWVKPAEEYDTLAGGKVKQLATGYTKRYKASELATVKTGLGASSSGKKGVIYAWGELPGSTSTFAPGVQQKLPGTRTLRLSTAGGAKWKLDFEQHGGVDESGFPIVDAFYTLGTPQTLKAGKSYGKTFNTAVFGPRVGSSLGIYREGNGIYGYLPVFTDGKTHSGSSLYSSVTTTLYRNGAKVGSNSDPLEGAGIFTVPAGDAAYKLTTSVKRSVKVAAASTRVDASWTFRSKKADLAKLPASSIRFDAAVGLDSRAPADKKVSVPVTVQGSAAGSNLKSLSVYVSYDYGQTWKKVTVKNGKIAVTNPAKGKGISFHAKIADKKGNKSTISLYNAYYGK
>NC_016582|1637303:1727625|1683974_1684448_+|WP_014173802.1|DBSCAN-SWA
MDPRLDRDVSNCSIARTLEVVGEKWTILILREVWYGSSRFSDFERVLGCPRNLLATRLRMLVEEGILATETYKEPGSRSRPKYVITPKGMDLVPAVMGLLQWGDRYRADPEGPAVLARHRACGAHVDVQVRCERGHSVQAEDIESVPGPAFRMKPAE
>NC_016582|1637303:1727625|1717736_1718480_+|WP_014173844.1|DBSCAN-SWA
MTDVAIADHKPRLAVLTGAGISAPSGLPVYRGGNGMWDRNPDTAKFTTASRWHGKAQQSWDHWNELRRASYTAQPNPAHQALVAAEAHFDVHIATQNIDGLHTRAGSTNVTELHGSVFRTRCSGKACHARHGAWFDENLHETVPTCPRCGRVARLDVVLFGEQLPARKMRASIDAARHADVWIAVGTSGTVFPAAGLIDFCRPGTVRVLVNAQPWTDNASTFEREVLGDASTVLGDVLRELHAAALR
>NC_016582|1637303:1727625|1640914_1641595_-|WP_014173754.1|DBSCAN-SWA
MRILVVEDEVDLAHTLHTGLTAEGYSVDLAHDGRQGLWMARTGEYVLIVLDLMLPGLNGYKVCAQLRRENNATPILVLTAKDGEWDQAEALDTGADDYLAKPFSYVVLVARLRALVRRAATVAPPVLAVGDLSLDVAGRVCRRAGARVELTPREFAVLELLARRAGQAVSKTDLLYHAWPDEAWDPNLVEARVSALRKKVDAAFHRQSLQTVRGTGYRLVDDRERD
>NC_016582|1637303:1727625|1710430_1710904_-|WP_014173835.1|DBSCAN-SWA
MTVKEDDANRRAAAQHALAEHLRLTAAGRTDEWVELFAPDAVLEFPYAPAGVPQRVTGRDALRAHMSNFPETFDVEFVDLVFHDTVDPSLVIAEFRSKGTALPTGKPYEQTCISVVRTDDNARITHYLDYWNPLVAIEALTPDDVPSDPDLSVTFGS
>NC_016582|1637303:1727625|1661802_1662237_+|WP_014173779.1|transposase|DBSCAN-SWA
MDLGDRAGCFRFLIRDRDSKFTAAFDAVFAGNGIAVIPTPPQSPRSNAFAERWIRTARAECTDRLLITGERHLRAVLTTYAEHYNTGRAHRSLDLRAPDDHPSVIPLPAAVVRRRQLLGGLLNEYHTTPPQRLLHPQETPSSAA
>NC_016582|1637303:1727625|1656909_1657806_-|WP_014173772.1|DBSCAN-SWA
MSASEAAATTHDGSIPGFGFNPPTAPVAGFELTELASLHERMADGSLQRVHRVDFHTVTLITEGSGEHAVDFVTYHCRPGTLLWIRPGQVQRFGRPGTMTGTHLLFTPTFPPHLAGTDRVVREWYGPVCRQLGTGHEYAALSALLSRVRAEFTRPDGTVSQEILQLLLATVLLHIDRLPQPGTNGDPHAGGEVYARFRAQLECSYATTRRAEDYAHRLGYTVKTLTRACLAATGQPVKQVIDARVALEAQRLLAHTDEPVAIIARRLGFSEPTNFGKFFTRHTGTTPGAFRRTHHAAQ
>NC_016582|1637303:1727625|1685929_1686406_-|WP_014173805.1|DBSCAN-SWA
MSDYYDLFLAVDLPPDLPEPVLLELRWLLGQADMPTELKSTDWESWGGPWQAFDGGSASHSFDGADVSLLVRAMDRPNLDGSEPWALTVRACVHEDDFGVTMDVVGWLLRHATTQGWVGFVRDSGLGQVRHLVRHEGGFDLVDVRPVGQQKRVPWSSR
>NC_016582|1637303:1727625|1713674_1714601_+|WP_106436541.1|DBSCAN-SWA
MFHARRTDAVLLLVAIVWGSSYLAAKTATYALPVLMVLFARYAISAIACLALVAARRRNGRYTRDEVRVGSLLGVTQAAVLVLETYGVAHTSAANAGLIISLTIVLTPLLDRTASNGRLPPRFFAATGVCLLAVTLLMSGSGFQTPRIGDLLMVAAAVVRAVHVALVGRLTKGRVVRPLHLTAVQTVVGSALFAVPASSGLPRLTQVDAAVWSQLVYLALFCSVFAFLAQTWAVQNSSASRASLLLGTEPVWAVAVGIGLGGEKFSTLAALGAALMVTGTYWGQSIERTHRTTNKEEPPCRTTTPTSV
>NC_016582|1637303:1727625|1652033_1652366_+|WP_043486169.1|DBSCAN-SWA
MDEEVILILRVEDAAAAVAWYERLGFAEQWEHRFEPGLPAFVELARGGMRLFLSEHKGDARPDTLVYLRIRNVEAIASEFGVQTKDAPWAREIELRDPDANRLRIGTPTE
>NC_016582|1637303:1727625|1714570_1715068_+|WP_014173840.1|DBSCAN-SWA
MPDNDTYQRLINLLDSTATVYKLIDHEPEGTTATVSALRGHPVSEAAKCLILIVKIDRRVTRYVLAVVPGDRRVDLNAIRTLFAARYVGFCDAATAERLAHAVPGTVLPFSFDPELELVADPDVIAQPCLYFNAARLDRSLAISGADYTRLAKPRVERITSPGSN
>NC_016582|1637303:1727625|1699258_1700011_-|WP_014173818.1|transposase|DBSCAN-SWA
MLRHCTDVEIDRQYTDTHGAPIVGFAFAHMLDFKLMPRPKNIGSAKLYRPAGGEDDQWPNLGPVLSTKTIDWDLIAQQYDQIVKYTTALHLGTAEAEQVLRRFTRSGPKHPTYRAIEELGRAVRTSFVCDYLADVEMRQEIHEGLQVVENWNSANKDLFYGEDGDLASSDKESQEVSMLALHLLQSALVHVNTLLMQHGPEVGGQAHRRGPPGLVTAVLDACESVRTVRARHEQPSRSRPRRAHPRPGDG
>NC_016582|1637303:1727625|1678003_1679893_-|WP_043488963.1|DBSCAN-SWA
MGTYEDVFRASTEDSESFWLKAAEGIDWDVTPQRALDSSGAPFYRWFPDGRLNVCFNAVDRHVEAGRGEQRALIYDSPVTGTRRTYTYAQLRNEVAAFAGALAQLGVGHGDRVVIYMPMVPEAVIAMLACARIGAVHSVVFGGFAPRELALRIDDAAPKVVVSASCGIEGKRVLAYKPLLDRAIELAAHRPEKSVILQRPQNLAELGPDDLDWGDLVAAAPPTDCVPVPATDPLYILYTSGTTGKPKGVVRDCGGYAVALHWSMGAVYDVGPGETMFTGSDVGWVVGHSYIVYAPLLVGATTVLYEGKPVGTPDAGQFWRVAAEYGVKTMFTAPTAFRAIRKEDPQGTLTAGYDLTGLRHLFLAGERLDPETYHWASDLLGIPVIDHWWQTETGWPIVANPVGIEAAPLKPGSPTLPLPGWDVRVLDPSGEPAPAGVDGAIVVKLPLPPGALPTLWKDDDRYVASYLSAYAGYYLTGDSGHIDDDGYVFVMGRTDDVINVAGHRLSTGSMEEALAAHPDVAECAVIGVADALKGQVPRGFVVLKAGIDREPSEVEAELVQLVRERIGAVASLKDVSVVAALPKTRSGKILRKTMRGIADGHDEPIPSTVDDPGVIEVLRPVLRRAGHTP
>NC_016582|1637303:1727625|1715265_1716270_+|WP_043488997.1|DBSCAN-SWA
MTVPQTALASDADDVERHPCSRCHASPGSPCRSRSGAVAGTYHTGRFTKVPRLAKLLRVPTPADRGPGQPWRPGTLLPAPIDPDTPTADIRIGYARCSSLTQELQSQLDALAAKNIPRDKIFAEKISTRVRVRPQFEAALAAAREIKAHAPHCRVIFTVNEMKRLGRDAAELTALADRLTAHGLVLEMLAGPLTGIYDPTGPGRLLFGFFAAMAETERENIREATLEGLDAASRKGKHGGRPPVITDDMLHTVLRRRANGETVEQIQPDLLIPTGRRKGQNPSLSSIYRALAEHEKAQAYPEAIEQAHTDFAALTATDDIARPRPARTVTSGIE
>NC_016582|1637303:1727625|1682612_1683626_-|WP_014173801.1|DBSCAN-SWA
MKAFVVEKYGKDGARAAEVPEPTVGDRDVLVRVSAASINPLDKMVRNGEFKQLLKYKLPFALGHDVAGVVTRVGSAVYGFKVGDEVYARPRDLRIGGFAEFISIDQDDVAPKPASLNLQEAAAVPLVALAAWQILVDRARVKPGQKVLIHAGAGGLGSTVIQLAKHLGATVATTTDTDTEKLVRSLGADVVVDYTKEDFSKVLSGYDLVLDSLGGANLEKSLTVLKPGGLAVGVVGPPDAGFAKQIGAPSFMGTVMNTLSRKIRKQAKTLSVRYQFFFMQANGSQLRKLSALYDSGKLRPVIDRTFPFDQTLEAMAYVEQGRTKAGKVVVSMVPDSD
>NC_016582|1637303:1727625|1674326_1675154_+|WP_078610855.1|DBSCAN-SWA
MGRTVEEIGSQVGPADGHVVDEVLRHGLDVADEAVLLGSQGERDPRVVDGIAAKRRVITFDNRGVGASTGSTPRTIQAMAKDAVTFIRALGFEYVDLHGFSMGGMIAQVIAQTEPQLVRKLILTGTGPAGGEGIKNVTRLSHLDTVRGLLTFQDPKQFLFFTRTANGRRAGKEVLARLKERTHDRDKAIFLRSYGAQLKAIHRWGLEQPHDLSVIHQPVLVANGESNRMVPSKNSADLARRVPNGELVIYADAGHGGIFQFHRQFVETALKFLER
>NC_016582|1637303:1727625|1704729_1705206_-|WP_106436309.1|DBSCAN-SWA
MTSTEAAASALQDHAALWSMGDARASDIVNAACDALVAGLDSPGLRILAACTRAEADYDVHALLPEALEELGLTFYPVASEAGQEAAARALARRMLAGELTPREFTFRIHQRHGHELALTERLAELDDEYDTLEYGDKTAAQVDAEVTAEARRLAAHL
>NC_016582|1637303:1727625|1650635_1651820_+|WP_043486168.1|transposase|DBSCAN-SWA
MGGDLADVRLWAGELSAVHERFVHRFSREEPRQSALAYMRGLIAPLERKNGWTLAEEAGHAGPDRIHRLLNRIEWDADEVLDDVRDYVVEHLGDRDAVLIVDDTGFLKKGIRSAGVQRQYSGTAGRTENSQIGVFLAYATDRGRTLIDRRLYLPTSWTDDRERCRRAGIDDSVAFETKVTMAKAMVRRAIRDKIPFGWVTADAAYGFSKGWRSELEQADVFHVMATTRHDTVVTRWAIDHPVHDLFPGLPRQKWKRRSCGTGAHGPRIYDWARVEVRPWHREDRQHWVIARRSVSRPEEISYYIAYCPAGTTLDELIRIAGSRWAVEECFQTAKQECGLDDYQVRRYPGWHRHMTLAMAAHACLTVLRARGLDADKAETDPPSSSTSASPRSGA
>NC_016582|1637303:1727625|1721936_1722707_-|WP_014173850.1|DBSCAN-SWA
MTAALQPTVDIRRSRERYKTELSWLDSKHSFSFSHHYDPQNTHHGLLLVNNDDIVTAGTGFETHPHQDMEIVTWVLQGSLVHQDSTGHTGLIYPGLAQRMSAGTGILHSEKNDSWRVEGVSPHTDPVHFVQMWVVPDEERITPGYEQLEIDDALLHGGLVTVASGMDRHADASAIRIKNKYAGLHAARLNPGDSVLLPEAPFLHLFVPRGTVTLEASGKLEAGDSVRFTATGGQRITADEPAEILVWEMHATVKGW
>NC_016582|1637303:1727625|1659622_1659787_-|WP_014173775.1|transposase|DBSCAN-SWA
MPGQAPLVAEQTFALLHQFKRLAVRWERRIELHDAFVSLACSLICCTRLKKTGS
>NC_016582|1637303:1727625|1654190_1655240_-|WP_014173769.1|DBSCAN-SWA
MTVPLDDFLGGLYRTFGPPKAMGESAPASDRPHFFLHRNFLGEQDLAILFNTKRCRYQCKFCALPFKSSREWIPKEGVLAQFRYVLEEDKHALGVLERVTIANEGSVFDQTTFPADALIQITAATRKLPRVRKIVLESRLEFLRAEQLKEIAQNSGKQLDILTGFETLDEDLRERVLGKREPLDVFLRGLDVVAEADCELTAYVLFKPDPVMTDEEAWAEAESSIDYLHEHCAARGIPLTIRLNPMYVAHDTQWARRAEKVENYQPPQLSDIITLAERKRAQGIAVYLGLTSEGLSDEDKTYRAREDFTRQLLKQGIVMNGDGSVSSRHHLLPLVEAGDPTPEPLLESK
>NC_016582|1637303:1727625|1658774_1659419_+|WP_014173774.1|DBSCAN-SWA
MSRIVVFGAAGKAGSRVVAEAAARGHEVTAVARDLSRIASVPAGVRLVSGDVTDPGTVTDLAKGADALVLTVGGPDAHLYTDAVASVASAGRALAPAGPRILHMGGGASLLNADGVRFFDAPGFPEEFKPYAIGQIQALDAYLGLGDDVTWTYLSPPPVHFAPGERTGRYRTGLDHPVTGEDGQARISYEDYAVAVVDEIENPRHLNRRFTVGY
>NC_016582|1637303:1727625|1639374_1640889_-|WP_014173753.1|DBSCAN-SWA
MNATGPRRRWWPRSVRARTALAAASAAAVILVGIGWWVHHDVYRESTQIAEGQAQAQFRALVDQVEEGVVPVRRSTVPYEVVATDRRGAVAYGGGMEEFDPGTRHVLPAPPKAELPAPPDDESSGWGYTTIPTRMPARPDSEPGDRFGKDGGTYLVMYHDVRADELSSDRVAALGVAADAQLRVYVVVLPHAAEDIAETITEATDRLLLRAGLVSLVLIAAVAYFAVRIALRPVEAIRVLTASVTASDPRERVTVPATGHEITALATTINTTLQRLDNAAAQQRRFVADAAHELRSPLTTLLASLEVALAYPERTDWPAAVTTASRQTRRLHALAEDLLLLARLDTRTPMAGRDTVDLAALASRLTEQYPLTEGGLTLTCDSTAPAPAHGNPDECERLLRNLIDNAARHAAHRIQITVRNQDGWVDLTVHDDGPGVPTEDAERIFERFVRLDDARSRDHGGTGLGLAIARDLAHRHRGTLTLTPRTLGACFQLRLPQAPTPAEE
>NC_016582|1637303:1727625|1648646_1649390_-|WP_014173759.1|DBSCAN-SWA
MTQDEPAEHRQFLDAVARALTEEDDIWQFHTPPGGSTLVARADDEAVALIAAGSLDATVTVDDIARVADLAARVGTTPAREGRPAAFVCSRRTPSGDAVQAAYLRNLRILSVHPTGEGSWGYDVAILSSHGFTQPQNTATLSKQQWGDVHADIYDAVFHDAQQTPIASFAGMRAELAWQEESHVSSWGNPWGSRHFKLPAGTSMTIPGRPSVPVTGVTLQFHKETRPLRATREESAFAELASDWLWG
>NC_016582|1637303:1727625|1655544_1655709_-|WP_158104703.1|DBSCAN-SWA
MRVLGLSEAVIGTVLAVATCLTVALPTLVNAWIGQAGSHRLVVGLSLQMAAMAA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014173751.1|1637303_1638401_-|transposase	transposase	NA	NA	NA	NA
WP_014173753.1|1639374_1640889_-	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	7.4e-05	19.7
WP_014173754.1|1640914_1641595_-	response regulator transcription factor	W8CYM9	Bacillus_phage	2.3e-22	29.7
WP_014173755.1|1642098_1645422_+	S8 family serine peptidase	A0A217EQY2	Bacillus_phage	1.5e-34	38.5
WP_143675894.1|1647267_1648221_-	hypothetical protein	NA	NA	NA	NA
WP_014173759.1|1648646_1649390_-	hypothetical protein	NA	NA	NA	NA
WP_043486168.1|1650635_1651820_+|transposase	IS701 family transposase	NA	NA	NA	NA
WP_043486169.1|1652033_1652366_+	glyoxalase	NA	NA	NA	NA
WP_014173768.1|1653717_1654050_-	hypothetical protein	NA	NA	NA	NA
WP_014173769.1|1654190_1655240_-	radical SAM protein	NA	NA	NA	NA
WP_158104703.1|1655544_1655709_-	hypothetical protein	NA	NA	NA	NA
WP_014173772.1|1656909_1657806_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_014173773.1|1657936_1658719_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_014173774.1|1658774_1659419_+	NAD(P)H-binding protein	NA	NA	NA	NA
WP_014173775.1|1659622_1659787_-|transposase	transposase	NA	NA	NA	NA
WP_014173779.1|1661802_1662237_+|transposase	transposase	NA	NA	NA	NA
WP_106436539.1|1662620_1665383_-	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_078610329.1|1665979_1666549_-|transposase	transposase	NA	NA	NA	NA
WP_043486173.1|1666787_1667873_+|transposase	transposase	NA	NA	NA	NA
WP_143675893.1|1667869_1668994_+	hypothetical protein	NA	NA	NA	NA
WP_086860112.1|1669028_1669613_-	hypothetical protein	NA	NA	NA	NA
WP_143675892.1|1669752_1670037_-	hypothetical protein	NA	NA	NA	NA
WP_014173788.1|1670248_1671346_+|transposase	transposase	NA	NA	NA	NA
WP_014173789.1|1671448_1672330_+	endonuclease/exonuclease/phosphatase family protein	NA	NA	NA	NA
WP_014173790.1|1672385_1672601_-	hypothetical protein	NA	NA	NA	NA
WP_078610855.1|1674326_1675154_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_014173796.1|1675310_1675883_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_014173797.1|1676310_1677378_-	alkene reductase	NA	NA	NA	NA
WP_043488963.1|1678003_1679893_-	propionyl-CoA synthetase	A0A2H4PQU7	Staphylococcus_phage	1.0e-56	31.0
WP_014173799.1|1680064_1680976_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_014173801.1|1682612_1683626_-	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_014173802.1|1683974_1684448_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_158104654.1|1685737_1685881_-	hypothetical protein	NA	NA	NA	NA
WP_014173805.1|1685929_1686406_-	hypothetical protein	NA	NA	NA	NA
WP_014173808.1|1688719_1689418_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_106436306.1|1689976_1690486_-	hypothetical protein	NA	NA	NA	NA
WP_014173810.1|1690896_1692498_-|transposase	IS4 family transposase	NA	NA	NA	NA
WP_014173812.1|1693651_1694593_-	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_014173813.1|1694693_1695107_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_043486181.1|1695306_1696908_-|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_043486183.1|1697357_1697981_-	LysE family translocator	NA	NA	NA	NA
WP_014173817.1|1698090_1699065_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_014173818.1|1699258_1700011_-|transposase	Tn3 family transposase	NA	NA	NA	NA
WP_014173819.1|1700033_1700468_-|transposase	transposase	NA	NA	NA	NA
WP_014173820.1|1701251_1701581_+	hypothetical protein	NA	NA	NA	NA
WP_014173823.1|1702257_1702704_+	hypothetical protein	NA	NA	NA	NA
WP_014173824.1|1702908_1703202_-	DUF1330 domain-containing protein	NA	NA	NA	NA
WP_014173825.1|1703390_1704293_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_106436309.1|1704729_1705206_-	hypothetical protein	NA	NA	NA	NA
WP_106436540.1|1705213_1706599_-	hypothetical protein	NA	NA	NA	NA
WP_014173828.1|1706838_1707168_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014173830.1|1707755_1708178_-	hypothetical protein	NA	NA	NA	NA
WP_193383691.1|1709171_1709414_+	hypothetical protein	NA	NA	NA	NA
WP_014173834.1|1709856_1710405_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_014173835.1|1710430_1710904_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_055413852.1|1712646_1713594_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_106436541.1|1713674_1714601_+	DMT family transporter	NA	NA	NA	NA
WP_014173840.1|1714570_1715068_+	hypothetical protein	NA	NA	NA	NA
WP_043488997.1|1715265_1716270_+	recombinase family protein	E5FFF9	Burkholderia_phage	1.4e-15	37.0
WP_014173842.1|1716366_1716795_+	hypothetical protein	NA	NA	NA	NA
WP_014173843.1|1716865_1717474_-	hypothetical protein	NA	NA	NA	NA
WP_014173844.1|1717736_1718480_+	NAD-dependent deacetylase	NA	NA	NA	NA
WP_014173848.1|1720486_1721014_+	hypothetical protein	NA	NA	NA	NA
WP_143675752.1|1721211_1721898_+	hypothetical protein	NA	NA	NA	NA
WP_014173850.1|1721936_1722707_-	pirin family protein	NA	NA	NA	NA
WP_014173851.1|1722744_1722939_-	hypothetical protein	NA	NA	NA	NA
WP_014173853.1|1725076_1725757_-	DUF1986 domain-containing protein	NA	NA	NA	NA
WP_014173856.1|1726557_1727625_+|transposase	transposase	NA	NA	NA	NA

Sequences of DBSCAN-SWA_4

Nucleotide sequences of DBSCAN-SWA_4

>NC_016582|10173037:10232574|DBSCAN-SWA
CGTGGCATGGGTCGAACGACGTGGCAACAAGTGGCGCGTACGGTACTGGAAGCCCGACGGCAGAGCCGGCAGCGTCCCCGGAAGCTTCGAGACCGAACCGGCCGCCCGCGCACATGCCGACCAGATGAACGCCACCGCCCCCGAACCCGCCGAGCCGCCGCACACCCCCACGCCCCCGGCCCCACGGCCCCCCACACCTGCCCCTACCACCCCCACTCCACCGGAGACTGTCACGGTCGCTGAATGGGCCGATATCTGGTGGCAGACCATGGACGTCGGCGACAACACCGAAGCTTTCTACCGCAGCCTGCTCACCCGCCACATCCTGCCCCGCTGGGGCACCACTCCCCTCGACCAGATCACCCCCGCCGACGTCCAGATCTGGCTCAATCGACTACGCGCCACCTACGCCACCGCCACAATCACCGGCATCCGGAAACTCTTCGCCATGATCATGACCGACGCCGTCGACAACCAACTCCTGGCCACCAACCCCGTACGCCCCCGCCGCCGCGGACGAGGCCGCATCGAACCACGCCACGAACGCCCCTGGGCGGATGAACACCAAGTCCTCACCATCGCCCACCGCATCCTCCGCCTGGCCGCCCGCAACCAGTGCCTGCTGGTGATCACCGCCGCCTACACCGGCATGCGCTGGGGAGAACTCGCCGCCCTCCACCGCGACAACCTCGACATCACAAACGGCCACATCCACATCACCGCCGACGCCGGAGCCCTCCACGAAGTCAACGGCCGCCTCACCCTCGGCCACCCCAAAACCTACGCCAGCGTGCGCACCGTGACCCTCCCACCCTTCCTCACCCAACTCCTCGCCACCGATCTGGCCGCCTCCACCCGCCCCTTCGTCTTCACCACCCTGCACGGCAAACACCTCCGCCGCTCCGGCTTCCAACGCCGCCTATGGGCCCCAGCCGCAGGCGGCGGACGCCACAACAGCGAAACATGGACGCCGGTCAAACAAGGGCTGACGTTCCACGGCCTGCGGCACTCCCACAAAACCTGGCTGATCGAAGACGACGTCCCCGACGTCGCCCAAGCACGCCGCCTCGGCCACACCATGGAAGACAAGAACGACGATGTCTATTCCCACGTCGCCGCCAGCATCGACGCCCGCCTCCTAGCCGGACTCGAGACCCGCTGGCACCGCTCCATCGAACGCTACCGCCACAACCGCAACGACCAAGGAGCCCCGCCCATCACTTCCTAAGACAGACCACCCAGAAACAGAGCGGTGCCCCACCCGTGCGGGTGGGGCACCGTATCGCTGTAAGGCCTAGCACATTTTGTAGTCGTACCGGCTGCTGTTGTACGAGCAGGCGTCGACCTTGGTGCCGCTCGCCTTCCGCAGGGTTGCCGTGTCGGAGACGTTGTTCCACACGTAGGCGCGGCGGTCCTGGTACTTCGTGTAGGTGGTGTCGGATCCGCTGCCGGTCCGCACCGTCACGGTCTTACCGGCACCGAGTGTGTAGGTACCGAAGGTGTAGCGGTGGTTGCTGGCGTCCGAGACGGTCCAGCCCTTGAGGCTGACGCCGCGTGAGGTGCTGTTCTTGATCTGCACGTACTCGCCGTTCAGGCTCGCGTTGGAGCGGGTGTCAGAGCCGGGCGAGTCGTAGTAGATCTTGTAGATGTGCACCGAGCCAGCGGCCTGCGCCTGGGCCGGCAGCAGGGCGATGCCGGCGGCCGCGGCGACGGCGGCAGCGCAGGCGACAGTACGGGCATGGAGCATGAGCCCCCCATTGACTCGTGCCGGGCACCCCCCCTATTGGTCCCGGCGAGGCTGATCACACTACGGGCGGAGAAAGACGAAAAGGCCCCTGTTACCGAATTGCGATGCGAGGTCGCTGCTCGGCCGTTGCTACTCAGGTGCCGTCCGGGTCAGGTCATGGCCGCGGTCACCTCGATGCCGAACAGGGTGAAGAGGCTGGCTCGGATGGTTTCCATGGCGGTGATGACGCCGGTGCACAACGCGACGGCCCGCATCCTGGCGCCCGGTGCCAGGGCGTAGTCCTCGCCTTGTTCCAGCCTCCGTCGGATGCGGCAGGCGCTGCCCCACACAGCGAGTGTGAGGTGGGTGGCGCCGCTTCCGTTCATGCCCTTTCCGTTTCCCGGACCGTCTTTGACGAGGCGGCCGTGGAGATAGGTGATCCGTGCCTCGAGCTGGCCCCGCAGCAGGTAGGTCTCGCCGGTTGTGCTGTTCAGGGTCAGGATGTCGTCCAGCAGTTCGGTGTTGCGGTAGGCGTCGGCGACAAGCTGGGCCAGGGTACGGTCGGCGACAGGCTCCGGGTGGCCGGTGAGGAAGCCAGGTGCCTGCTCGGGCACGGGGGCGGCGGTGATCGCGCCGTGGATGTGGATGTTCTGGTAGGCCGCGTAGGGGTCGGGAGGGCTGGGCAGCGGTACGTCTTCGGTCGGGACCGCGTGCCAGTGCACCAGGGAGCTGCCGCGGTCGGCATCGAGGTTGTCGGTGACGGCCTGGAGTACGCCGGCGTCTGCGCGGGCGAGGAGGGCGTCGAGTGCTGCGTCGGAGTGGTTCATTGCGCACCTCCGCTGGTCAGGCCTAGCAGGTCTTTGAGCTGGGCGCGGGCACGGGCGAGGTTTTGCCGGACCGCGTGGGGTTGGATGCCCAGTTCGGTGGCTATCTCGCTGGTGGGGAAGCCGTCGAGATGCCAGGCCATCACCTGGCGTTGTTTCATGGGCAGCTGGGCCAGGGCGGTGTAGACGCGTTTTTCTTCTTCCTGCAGGACGACTTTGTCCAGGGGGCAGGAGAAGGCCGGGCGGTCGGGTACGTCGCCGGTTAGCTCTTCCTGGGGGATTGGGGCCTGGCGCAGGTACTGGCGGAAGGCGACCTTACGCAGCCAGGCGGCGGGGGAGTGGATCAGATGCCAGGCCCGGAAGGCTTCGATGAACGCGGCCTGCGCGGCATCCGCAGCCTCGTACGGGTCGGCTCCGTACCGCATGACGAACCGGATCAAGGCGGGCATGTGCTGCTGGTAGTAGCGGGCGAAGTCCTCGCGGATCACTTCGTCGTCGGCCGCGGGCACCGAGGGCCGGCGCTGGCCGGGGAGGAACACCGGGAGAGTGGGGCTGCCGTGACGTCCCTTATCCACGGGCTCCTCCGCGCGGCGTCCCCACCTGGACTCGAACGTCCTCGCCGTGGTGGCGCTCGGTCAGGGTGCAGCCCGGCGGGAGTGCCCGCACGCGTTCGCTGATGCCCTGCTGGCGCACCCGGGCCAGGCGTACCCGGTCACGGCTGCCGATCCACACACGCAGCAGACGCACTCCCGCAAGGCAGGCCGTTCCCACGGCTGCCGCGACCGCGATCTCCATACGGCTCCTTACAACTCTCGTTCGGCGGTGCCCGGATGCAGCGCCGGTGGACTTATAGGAGTGCACGCTGAGTCGCATTGTGTGACATCTGTTGTGGGACGAGTTGATTGTTGCTGGTGAACGGCGTAGTGACGTGCGGGCTGCTGGATCTGGCACTACCCGTGCGCGCTCGAGGGCGCCTGGAAACGTGCTCGATCACACCCGCTTAAGGGTGAATCGCCGTCAGCTTCGTGTTCAGCCTGGTGCTGATGCCTCACCGTGATGGTCATGATGATGCGTCGCTGGGCCGCCGCTGCGGCCACTGTGCTGATGACCGCCGGTCTCGTAGGCTCCGCTGCCCCGAGTTGAGCCTTGGCGGGTACTTCTTCCGCCGCGAGCGCCCCTGTATCGGCGTTGGAGCTTCCGGAACCCCCGACTGCTGAGGAGGCTCGGGCGGAGCTGGAGGAGCTGACCGTCGCGCCCGAGGATGACGCCCCGGGATACAGCCGGAGCCAGTTCCCGCACTGGATCATTCAGCATGGCACCTGTGATACCCGGGTTATCTGCACTCGCGGTTCCGAAGACTCATGTGAACCTGCTGGCAAGAGCACACTTTAGCGAAATGCGGTGGTCAGAGGCACGTGAGGGACAGTAAGTCGTCCTGGCCTGGCCCGTCTGGCCAAGGAGGTCTGGAGCCACCAGCGCTACGCTGGGCACCGCGTCTCGGAGCGCGCTCGCGGCACCATCGGTAGCACCACCTGTCTTCTGGCAGCATCGCTACACCCGGCCCGAGCTGCTTCAGCAGGGGGAGGAGGCGCAGCTTCTGGTGGTGGGCGGCGCGGTGCGGCGCCGCAGGAAAACTCATCGATGCCCCTCTCGGTGATCCCGGCACCGCAGACTCACCCACTTCGGCGCCTGCCGCTGACCGGGACCGCATTGTCCAGTCCACCGGTTTTCAACTGCACTTCGATGAGGACTGGGCAGGTCACCGGCAACGTCAGCCCGTCGGCCCATACGTTCTCCTGGAGGTCCTCTGTGCGCCCTTGCCGTGTCGTGATTGCCGTGGCTGCTTCGGCCGCAGTCGGTGTCTTGCCCTTCGCCGGAACGAGCGCTGCGGCCCCTGCGAGGGCAGCGGCTGTCACGGTGCCGCTGCGCGAGGCCGTGGCGTCGCTGCCCGTCGCCGCCGAGGACCGCACCGGTTACGACCGCGAGGAGAGCTTCGGCACCTGGATCGATGCTGACCGCGACGGCTGCAATACCCGCGCGGAGGTCCTGCTGGACGAAGCGCTGCAGGCGCCGGAGGTGACCGGCCGGTGCAGCCTGGTCCCCGGCACCGGCCGCTGGTACTCCTGGTATGACGACCAGTACGTCACCAGCGCCCGTGATCTTGATGTTGACCACATGGTGCCGCTGGCTGAGGCGTGGGATTCGGGCGCCTCGGCCTGGCCGAAGGTGCGCCGTGTGGCCTACGCGAACGACCTCTCCGATCCGGGCCACCTGGTGGCGGTCACCAAGCGTTCGAACCGGCAGAAGAGCGACCGGGACCCGGTGGAGTGGATGCCGGACCAAGCGGTGCACTGCCACTACACCGCGGATTGGGTCACTGCCAAGCTGCGCTACGGCCTGAGCGTCGACCTGGCGGAGAAGCGCAAGCTCACCGAACTCGCCAGCGGTTGCCCCAACGCCCCGTTGACCTACACCCCTGCGCCCTGACCGGGCCCGCGCTCCTTTCCGGTGTCCAGCAAGCCGCACTCCTCGCGCCGTGTGTTCGTGTCGGTGGGGCTCGACCGGAAGGTGCGACAGCTGCTCAGTCACAGCGGTACGGGAGAAGCCATGGCAGGACCTCTCGACGTATCGCCCCATTGGGGAGGGTTCTTACAGGTGGAGACGGTGGCGTTGCGCCCGTACAAGCTGGCCGCGGGACCTATAGGGCGGCGTTTGTCCATCGTGGCCCGGGTGTACGGGTATCCGCCGGATCACAACGCCGGCTCCGAGTGGATGCTGCACTCGATGCTCCGTCCGCTGGCCGAGCGCGGTCACCAGGTGGCGGTCTGGCTGTCGCACCCCCAAAGGACCGAGAAGGCTTACGAGATCGACGGGGTGCGGGTCGTCCCTTTCCAGGAAGGCATGGACTTCGCCGCCCATGCCCAGAAGGCGGATGTGCTGTTGTCCCACTTCGAGAACGTGCCTCTGGTGGCGGGGCTCGCGCGTGACCGTCTCATCCCTCTGGCCGTGATCTGCCACGACAACTTCGCCACGAGTTTCCACAACGCGGCGGGCGCTGATCTGGTGGTGTACAACAGCGAGTGGATCAGACGGGACGGCGAGATCTTCTACGCCCGTTACCCACGGGAATTCCTGCCCAGGAACAGCATCGTCGTCCGGCCGCCGGTGATCGCGGAGGAATACCGCACCCAGCCCGGCGACTGCGCGACCCTCGTCAATCTCAACTCCGACAAGGGCGGCGAACTGTTCTGGCAGATCGCCGCCTGGACCCCGGGCTGGAAGTTCCTCGGCGTCCGCGGCGCCTACGGGCAGCAGATCATGCCGCCGCCGCGGCTGCCCAACTGTGAAGTTCTCGACTCGGTGCCCGGACAGCGGATGCGCGAGCACGTCTACAGCCGGGCGCGCGTGATGCTCATGCCGAGCCTGTACGAGTCCTGGGGGCGGGTGGCGGTGGAGGCGTTCGCCTCGGGCATCCCGGTGATCGCCCACCCCACCCCCGGGCTCGTCGAGTCCCTGGGCGAAGCCGGCATCTTCGCCTACCGCGACGACCTCAACGCGTGGGTCCACGCCCTGACGTCCTTGCAAGACCCCGACAACTGGGCCCGGGCCTCCCGCCGGGCCAAGGCCCGCTCCATCGAACTGAGCGCGGCCCTCGACCTCGACCTGTGGTGCGACGCCGTTGAATCGCTGGCAAGGACGCGCATACCGAACGGCTTCCGCAGGCGCGCACTCGGCACGGTCGTCGATGCCAGTGAGATGGGCCGCGGCCCTGGGAGCGACGCTGCGGCCCGGAAGACCGAACCGCACGTCCGTCACGGTGCCGCGGAGCACGGGCGAACCACGACCAACTCTGTCGACCTGTAATGAAAGGACGGTACGCCATGACCGAGGCAACTCTTCTGGCCACGACCGAAACCGCCATCGTCATCGAGCCCCGTGCGGCCATCGCACAGGCCACCAGCGCACCCATCGCTCCCTACACCCACATTCGGCGCTTCAACTATTCCGGCGGGGTCGTGGACTTCATCGTTCCTCCCGGTGTCACGACGATCAATGCCCGCTGCTGGGGTGGCGGGGGTTTGGGAGTCGACACCGGGGGTGGGGGCGGGTTCGTCACCGGGGACGTCGCTGTAGTGCCGGGGGAGACACTGCGGGTCGTTGTCGACCTGGGGGGAGGCTTCAGTGGCGGGGGCGGAATGAGCGGCCTGTTCAGCCAGCGGCTGGGACAGACGCTTCTGATCGCTGGAGGAGGCGGAGCGTCGGTGAATGTCCTCGACGCGCGTGGTGGTGCGGGCGGCGGCACCAGCGGTTCCGGCGGGCGGCTCGTCACGCAGGGTGGGGCGACAGGGACGCCGGCGCGTGGAGCTTCGGGTTCGACCGGCGGCGCTGGCGCGGTCGTCAGCTCCGGTAACAGCCGTTATGGGGGGCGTGGCGGCAGCACCGGCCAGAACGGTGGCGCCGACGGGAGGGGAATCTCTGGGGGCGAGGTGCCGATCTTGGGTATGGGGGGAGGCGGGGGCGCAGGCTTCGGCGGCTCTACCGGTGGAGGGGCCGGCTCCGCGGGTGGCGGTGGGGGAGTCGGCATGAGCATTGCGGAGGGCGCGATTTACAGCGGCGGTGGTGGTGGCAGCAGCTTTGTGAACGGCCCGGGCGTCACCGGAGGGCAGACCCTGGCCGGCAATGGCACCCAGGCAGGCGGTAAGGACGATCCTCTGCACCAGTCTCCTGTCGGTGACGCGGGTAACCGTGGCCAGGTGGTGCTGCAGTGGACGGAGTTCACGGTGGTGCCCGGTGGTCCGCCGGACGTGGAGCTGAGGCAGGGCGGAGCGGTCGGGTATCCGGGAGTGCGGGTCGAAGCCGGCGTGGCGATCGACCCGGTGTCGGTGACGGTCGCCCTGCCCCCCGGCCGTGGTCTGCTGTTCGGTACGCAGACGCTCGCCGACTACCAGTTGACCGTTCAGAACGCCGACGGGCAGACGACCCCCTACATGGGAACCCTGTCAGAGGACGGAACCTCGCTTCTCTTCTCGGGCGTGGACCTGGGGCTGCCCGGCACGACGGTGATGTGGGTCGCCGTGAGCGCCGGCCACGACGCCCCGCTCGGATCCACCAGCCTGGCCTTCACCGTCGGGGGAAAGACCTCCCCCTCCACCACGGTCGTCGTCACACCCGGCTACACCGTTTCCCCCGGCGGCGCGCCGGTGACCGCGGAGCGGGGAGGATGGCCCGTGTATCCGGGCGTGGAGGTGCGCAACAACGGATCACAGTCCATCCCGCGGCAAACGGTCACCGCGAAACTTCCCGCCGGCGTCGCCATGCGGTTCGGCGCGCAGGACAGCCCCGACCACCAGCTGACCGTCTGGGACGCAGGCGGAAACACCACCGTGTACATGGGGAGCGTCTCCGACGACGGACAGTCCCTGACCTTCTCCGACGTCGACCTGGGAATTCCCGACGCCGGATCCCAGTCGGTCATGTGGATCTGCGTGAGTGCCACCGACGACACGCCTCCGGGCCCCACCAGCGTGGAGTTCTCCGTCGGCGACCGCATCTCACCATCCACCACCATCAACGTCATCTAAAGAGGCCGTTTTCTGCCTTGTGGAAGGGGATGGCCTGCTTTCTGCTGCGCGCCAGTGCGGGTTGGGCCTGTCAGAAGCCGTATCTGAACCGATCATGGAACGTGCGGGTCGAACAGGTTTTTCGCCGGGGTGATCTTCCCGTCGTACGCGTATGAAGACGGGGCCTCTCGGTAGCTCGAGGATGCGAATCCAACCGAGCAGTGCCGGGAGGCCCTGATGTCGTTGTTGTGCGCCTCCGAACGCCTCCCATCCAACGCGGCTGCACGATCGTGTGATCACCTCGCGCACGCGTACGGCAACGCGGTCGGCCACCGGGACCGGGAACGCCGGTATCCCTCCGTGTCTAGAACGGCCTCTTTGGGGGTCTGGCACAAGTTCCGTGAGACGACCACAGGTTGTAGTTGTTGATCTTCCTGGGGCCGTGTCGAAGTCGCCTTGAAAGCGCTCCTGGTCCGGATGGTGCGGCTGACATTCGGTGGCCGTGAACGAGATGTTGTCCCGTGGCTGTGCCACTTTCAATGGGAGTCATTTCGAGGTGACTTGCGGAGTCGTTTCGCGGCGGCAGACAAGATCAATGCAGGTGACTTTTGATGTCGTTCCCGACCGCCGCGCCGGGGGCTGGGGCCGTGGGATATCTACCTGGAGCCTCGCCCCTGCACCGCGACGGACGAGCTGGTTCGGGGCTGGAGATCGGCAAGCAGTACGCTCATTCCGCAACACGACGCGAAGGGGAGATCGGTGGCGCGGGTTGCGGTGATCGGCGGGGGTATCAGTGGGCTGGGGACGGCGCTCATGCTTGGCCGACGGGGCCACACGGTCACGTTGTTCGAGCAGGACGCGCGGCAGGCCGGAGAGGACCTGGACCGGGACTTCTTCCACTGGGACAGGCCCCGAGTCCCGCAGGCCAACCAGCCCCACTCGCTGCTCGCACCCGTCCGCACTGTGTTGCGCGCGGAAGCCCCTGATGTCTATACGGACCTGCTGACACGGGGGGCCCGGGAGTACCACGAGTTCGACTGGTTCCGTGAGCATCCGCCGCATCGACCTGGCGATGAGGACTTGGTGACCCTGCGCACCCGCCGCATCGTGCTGGAGGCCGCCCTGACTGCGGCGGTGCGGCGGGAACCCACCGTTGAGGTGCGGCGAGGCTGCCGGGTGCGCGCGCTCACCCTCCGGGAGGGCCGTCCTCCCCGGGTTACCGGCGTGCAGGTGGGCGCGGAAGTCCACCAGGCGGACCTCGTCGTCGATGTGTCCGGTCGTCGTTCGCCGGTGCCCGCCTGGCTGATCGCGGCCGGATGCCGCCCGCCCGTGGTCGACAGTCACCGCGCTGGGATCGCTTATCTGTGCCGCTGGTACCGCCTGCGCGCCGACGGGCCGCGTGATCCTGGCCAGGTGAAGACCGGCTCGGCCGCACCGTTCGCGCTCGGCGGCGTCTTCCCTTCCGACAACGACACCTTCGCGGTGAGCCTGGTGCTCTCCACGAGTGATCCCACCCGCGGCGCGCTCACCGATCCTGCCGTGTTCGAGGCAGTCGCCCGCCACTTCCCCGCGACCGCCGCCTGGCTCGACCTGGCCCCGGAACCACAATCCGCCGTCCTGGCGATGGCCGGCCTGGACAACCGTTGGACCGCCCTCTCCGACGATGACGGACCTGTCGTCACCGGCCTGGTCAACGCCGGGGACAGCCTCATCCACACCAATCCCACCTTCGGCCACGGCGCGGCCCTCGGCCTGCGTGCCGCCCAGTACCTCGCCACCCATGTCGACCAGATCGTCGCGGATCCCATGGGCTACCACAGGTGGGCGGCACAGGCCCTCCGCCCGTGGTTCGACGCGCAGGTGAAGGCCGACCGCGCCGACGAGCAACGCCTCGCCGAGGGCTCACCATCCGCAGATCGGCGGGCTGCCGCCCTGGCCGCTTGCGCCTTTGACGATCCTGTCGTCATGCGAGCCCGAGCCCAGGTGCGCCATCTCCTGCGGCTGGCCGACGACGCCTATGGCACCGACGAAGTGGACCGACACCTCACCGCCTGGCTGGCTGCCCACCCAGACTTCACGCCGAAACACGACGGCCCGACCCGAGATCAGTGGGATGCACTCATCCCCACCTGAGCGCTCGCCGGGCACTGCAGACCTCATTCAGATGGCTTCAGCCCTGAAGGGTGTCTTTATTGCCGTACGGTCGTTGACCTGGGGCTTTGTGATCGTCCACGTATGGGCATGATCAATGATTGTGGGTCTGCGACTGCTCTACTTGATCTTCTGCCGGCTACTGGGCTGTCTTCTTTTGCTGGGCCGGTCGACCGCCGCGAGCAACGCCGAGATCCTCGCGCTTCGTCATGAGGTCGCTGTGCTTCGCCGGCAAGTAGTGCGGCCGCGGCTTTCATGGGCTGATCGTGCCGTGCTCTCCGCTCTCGCCCGGCACCTGCCATCCGTCTTGCGCCGCCATCGCCTGGTTACCCCGGGGACGCTGCTGGCCTGGCACCGTCGTCTGGTGCGCTGGAACTGGAGTCAGACGGCGGTCGGACCCGGTCGGCCACCGCTGGCAGAAGAGATTGCGGCGCTCATCCAGCGCCTGGCGCGAGAGAACCCGACCTGGGGGTACGTCAGGATCCAAGGTGAGCTGCGACGGCTTGGCCATCGGGTTGCCGCCGCCACGATCCGGCGCGTCCTGCGCCGCTCCGGCCTACCACCCGCGCCGCAGCGCGCATCCCAGCAGACCTGGCGTACCTTCCTCCGAGTCCAGGCCCACACGCTTCTGGCCTGCGATTTTATGCACGTGGACACCGTCTTCCTCAAACGCCTCTACGTCTTCTTCGTCATGGAGACTGCCACCCGGCGCGTTCACGTCCTGGGCGTCACCGCCCACCCGACGGGCGCATGGGTCACTCAACTCGCCCGCAATCTGCTCATGGACCTCGGCGACAGGGCTGGGTGCTTCCGGTTCCTCATCCGTGACCGGGACAGCAAGTTCACCGCCGCATTCGACGCCGTCCTCGCCGGCAACGGCACAGCCGTCATCCCGACCCCACCGCAAAGCCCACGATCCAACGCGTTCGCCGAACGATGGATACGCACAGCCCGCGCAGAATGCACCGACCGACTCCTCATCACCGGCGAACGACACCTGCGCACGGCCCTCACCAGGTACGCCGAGCACTACAACGCCGGACGAGCCCACCGCAGCCTCGGCCTACGAGCACCCGACGACGACCCGCACATCATCCCCCTGCCCGCTGCCGGGGTCAGGCGCCATCAGGTACTCGGCGGACTGCTCAACGAGTACCACACCATGCCACCCCGGCTGCCTCATCATCCACAGGAAAGGCCCAGCTCAGCAGCCTGATTGGAATATTGACACCCTTCAGGACTCTGTTGGTCGATGTGATGGATCGCCTGAAATGACCTTCGGGTGCGGTGGACACTGCTCGTTGTCGGGTCTGTTTCCTGGGGGCGAGGGGGAGATCATGTCGATGCGTCCGTTGCCTGCGCCTGCGGTGCCTGAGTCCACGGCGAGGGTCGCCCGTGCTGCGTTCCCGCGCGGGTGTCTGGCCATGCGGATCAGGGACGAGTTCGGGGCGGTGTTTGAAAGCGAGCGGTTCGTGGCGGCGTTCGCACATCGGGGCGGTCCGTCCGTGTCTCCGGGGATGCTGGCGCTGGTCAGCGTGCTGCAGTACGCCGAGCGGCTGACCGACCGGCAGGCCGCTGATGCCGTGCGTGGCCGGATCGACTGGAAATACGCCCTCGGCCTCCAACTGGCCGATCCTGGCTTCGATTTCTCGGTGCTCAGCGAGTTCCGTGACCGGCTGATCGCCCACGGCCTCGAACAGCAGATCCTGGACGCCATCCTCGCGCAGTGCAGCGAGCGGGGTCTGCTGCGGGCCGGCGGGCGCGCCCGCACCGACTCCACCCATGTCATCGCCTGCATCCGTGACCTGAACCGGCTGGAATTCGTCACCGAGACCATGCGCTGCGCCCTGGAGGCCCTGGCGGTGGCCGCTCCCGCCTGGCTGGCCGGCACCGACGCGGTCAACACGGACTGGCTCGCACGCTACCGGCAGCGCGCCGACTCCTACCGGCTGCCCAAGGGAGAAGCCGAGCGCACCGCATTCGCCGAGAACGTCGGGGGCGACGGCTATGAACTCCTCGATTCTCTCGACGATCCCACGACCCCCGCCCACCTCGCCGACCTCGAGGCGGTCGTGCTCCTGCGCACCGTGTGGGCCCAGGAGTACCAGCGCGACGCCCGCGGGGTGCGCTGGCGCGGACACAAACAACGCCCTCCGGGAGCGGCGCGCATCGTCTCCCCGCACGATGTGGACGCGCGCTGCGGGGTGAAACGGGGATCCGCCTGGGACGGCTACAAAACCCATCTCACCGAAAGCTGCGACGACGACCTCCCACACTTGATCACGTGCACGGCCACCACACCGGCCACGACGGACGACCACCAGCTCACCGCCGCTGTCCACCAGGCCTTGACCGAGCGGGGCCTGAAGCCGGCCGAACACTACGTGGACGGCGGCTACACCAGCGCGAAGATCATCCTTCAGGCCCGTGCACTGGGCGTCGAGGTCATCGGGCCGGTCAAGCAGGCCGGCGGCCGACCGGCCCTGCAGGGCAGCGGCTACGCCGCCACCGACTTCCGCATCGACTGGCACACCCGGCAGGCAACCTGCCCGCAGGGCCAGGTCAGCACCCGCTGGAGTGACACCACCATCGGCGGCGAACCCCGCATCCACATCGACTTCTCCCGGGCCGGATGCACCAACTGCCCGGCCAAGGACATCTGCACCACAGCCGCCTACCGCGTCCTGACACTACTCCCGCGCGAAGAGCACGAACTCCTCCAACAACGACGGGCAGAACAGCAGACCGAGGAATGGAAGAAGCGATACCACACCAGGGCCGGGGTGGAGGGCAGCATCTCGCAGGCGGTACGGCGCACCGGCACCCGGCGCACTCGCTACCGCGGCCTCGCCAAAACCTCACTGGCCCAGGTCCTGACCGCAGCCGCCCTCAACCTCTACCGCCTCGACGCCTGGTGGACCGGAACCCCCCTGGGCACGACACGAATCTCCCACTACGAACAGCTTGCCCTCAGTCTCGCGGCCTGATCGACAAAACCCAGATCACATCGACCAACAGAGTCCTTCAGGCACCGACGGCGTCGGTATCGTGATGCTGGTGGTGGCGCTCGCCCACCAGACGAGCCGGCTACGGCAGAGCGCCGCTCCGTGCGCTGCACGCCCGCAGCACCTGCTGAGGGCATCGGGGCAAGCCGAGGATCACGGGGCCGTTGAGAACTGCCACGTGTTCACGTTGAACAGGTAGCCGCTGCCGCCAGCGAACTTGAGGTACAGGTTGCGGGTCCCGGCCGCGCCGTGCACCGGGCAGGAGACGTTCACCCAGGTCTGCCATCCGCCGGTGCCCGGGACGGTGCACGTCCCTACCTGCGGGCCGTCGGCGCCGTCCAGGCGCAGCTCGATCCGGCCGCCGGTGGTCTGGGAGGAGACCCTCGCGGTGAAGGAGGCCGCACCAGCACGGAAGGCTGCGCCCTTGACCTTGATCCAGTCCCCGTTCTCGATCCAGCCGACGTTCATGCCGCCTTCGCTGGACGGCTGTGTTTCGATACCGGAGGCCCAGGCGCTGGTTTCGGCCTCCTGCCGGACGTAGGGGTTCAGCGTCCCTACCTGGGGTGCCCCGGCCGAACTCATGGTGATCGTCGGGAACGTGCCGTCAGCGTTGTACGCGAAGCGCTCCACCGCGACCGACCGGGTGAACCCGCCGCCGCCCGGCAGGGCCCCGTTGTGGTAGAAGAAGTAGGAGTTCCCCTTGTAGTCGACGACGCCGGCGTGGTTGGTGAAGCTGCCGCCCTCCCGCGGCATGATCGTCCCCCGGTAGGTCCACGGCCCCGTCGGGCCGGGCGCGGTCGAGTAGGCGATGAACTCGGAGCAGCACTCCGCCGCGAACACCATGTAGTAGAGGCCGTTGCGCTTGTAGACCCACGGCCCCTCCTCGTACAGGGTCGGGCGGTCCGGGTTCCCGGTGCGGCTGCCGAACCCTTCGGTGGTGAGGGGGATCCGGGTCGGGCTGCCCGAGTACGACGTCATGTCCTCATTCAGCGTCACATACCACAGGTTCGGGTTGCCCCAGTACAGGTATGCTTGCCCGTTGTCGTCGATGAAGACGGTGGGGTCGATTTCGCCGTTCTCCACCAGCGGGTGTCCGAGGGCGTCCTGGAAGGGCCCGAGGGGGCTGTCCGCGACCGCCACCCCGATAGCCATGCGTCCGGTGGCCGCGTTCGTGACCGGCACGTACCAGTAGAACTTCCCGTTCCGTTCGGTGACCTGGCCCGCCCACGCGTTCGCGCTCGCCCAGCTGAAGGTCTCCACGCTGAGCGGGGAGCCGTGATCGGTCCAGTTGGCCATGTCCGAGGACGAGAACACCCGCCAGTCCTTCATGGTGAAGTTCGTCGAGCCGTCCTCGTCGTGACCCGTGTAAAGGTAGACGCGCCCGTCGTGGACCAGGGGGGCTGGGTCGGCGGTGTAGATCGTCTGGACGACGGGGTTGTCCGCTCGGGCCGCGGTGGGCGCCAGTACGGCGGCGAGGCAGAGCAGGCTCAACAGCCAGATCAGGCTGCGACGGGGCATGAGGCCGAGCGGAGTTGGCACAGGTACGGATTTCATCGTTGCTCCCAACGTGGTGATCGCTTGTACTGCTCGTGCCGTGCGCGGGCTCCTCTCCTCGGACACGAGAAGCTTTCTGGCCCACCCGCACGGCGGCGCGCGGCTCGGCGTGCGGGCGGGGGCGGGGGTCCGCGGCGTCTCAGAGCGGGCTCTCTGCCTCGACGTCAGGCAGGCTGCGTACCGGGCGGCGCGGAGCGGTGTGCGTGCGGTCAGTTCTTGGAGCGATCCGTCAGCATGCGGGTGCCGCGTCCTGCCGTTTGACCGCGTACCCAGGTGAGTGCGCAGTCCGCTTGCATCGCGGCCTGGCGGGGCGGACGCGTGTGGACGGGTGAAGCGCGGGCGTCAGTGCGTCACACGGAAGGTGGCGTCCTCCCGGCCGGGCGATCCGGAGATCTCGTGGAGGTAGAGCACCTTGCCGGAGTGCCGGATGTAGCGGTCGGGGTAGTTGTAGGAGCGGAACGAGGACCAGTGGGCGTTGGCGAGGCCGGCTTCTTTGTAGAAGGTGGCGTCGGCCTTGAAGCCGGCGCTGCCGTCGCTGCTGGACAGGCGTACGTCGAAGTTCTGGTGGCGCAGGTACTGCCCTGGATGGTTGACCGACTCGAAGGAGACGCCGGCCGGGTCCGCCAGGCCCGGTACGAGGCGCCACTGGCTGTCTTCGTAGGGCTCGAAGGGCAGCTCGTCGATACGGCCGACGAATCCGGAGTGGCGTACGTAGGAGCCGGGGAAGTTGAAGGACTTGAGCCGGTTCCACTGGGTGCTGCCGTAGACGTGCACCAGCCTGTCGCGATCGGCCGCGGTGATGGGGTGGATCGCGTTGTGCTTGGAGTTGAGCGGGGGCGTGTAGTCCTGCCTGCCGAGTTGCGTCCACTGGCCGGACACGAGGTCGCCCTGCCAGACGTCGAACCTGTTGTTGGGGCAGAAGGTGTCGCCCCACAGGTACCAGGTCGGGGCGGTGAGGGATTTGACCAGGGTCGGCGCCTCGGTGCAGCCGTTGGCCAGGATGTTGTCGGTGTAGGGGGTGAAGCTCCCGGGCTCCAGCGATGCGGACCGCGTGCCCCGCAGGCCCGCGTTCCCGCGGACGTACAGGTAGTTCATACCGTTGACGCCGGTGATGACGGTGCTGTCGATGACGTCGTAGTCCTGGGCGTCGTAGAAGACGACGGGGTCGGTGGCGGTCACGAAGTCGCTGGTGTAGCTGACCATGATCACTGAATGGTTCGCGCCGGCGGGGACGGTGGAGAAGGTGATGCCGTACTGCCCCCGCTTCGCGTCCCAATGGATGGAGGGCGCCCAGGAGAACGAGTCCGGGTTGGTGCGGTTGACGGCGAGAAGGCGGTCCTGCGACCAGTTCACGAGGTCCGGGGAGGTCCAGACGTGGATGTTCGGGTTCGGCGCCCAGAAGTTGCTGTCGGCGATGTCGGTGGCGAGGACCACCCACGTGCCGTCGTTGAGGCGGTGGATGAACGGGTCGCGGATGCCGCCGGTTCCGGCCGTCGGCGTGAGGATGGCCTCGCTGTTGTTGAGCGGCGTCCATTCCAGGGCGTCGTCGCTCACGGCGAGATGGACGGCGTTGACGTTCCCGGCCCCGCTGAGGGACTCCTTGAAGTACGCCATGACGTACGCGTCGTCGGCGTTCGCAGCGTGGGCGGACGGGGCGATTCCCAGCATGAGGGCCGCTGTCATGGCCAGCGCGGCGATGGTTGCCGATGACTTCAGCAGAAGTCTCAGCCTGTGCAGAATCATGTGACGCCTCTCGATCAGGGAGGGATCCGTGTGCGGGGGGGTAGTGCTTTGCCGCGGCCTCAGGTCGGGCGGCCGTGAGGGTGGGGTCGCTGTTCGACCGTGGATGCGGACCGGGCCGTGCTGTCACGGGGACCTGTCCGCGCTGTGCGCTGCCTGGGTGAGGGCGCGTTGAACGGGCCGCTGGACGAGGGGTCGTGAAGCGGCCGTGCGCGAGGCGGCGCCGAGTGGCCAGATGCTCCTACACCGCGGTGGCGCTCAGGGTGTGGCCAGTTCGAACCGTCTGATGTGTACCGAGCCGCCGAGCGCGCGGGTTGCGTGGTGGAAGAGGGCGAATCGGTAGCCCATGAAGAACTGCCAGTCGTTCTTGAGGACGAAGGCGGCGCCCAGGAGGGCGAAGTTGGTGCCGTCGGTGCTGTAGGAGAAGTGGCCTTCGCGGCCCGTGCCGGGGCGGATGTCGGCGGTGGCGCGCAGCCAGATGCGGTTGCCGTGGATGCTGGTGCTGACAACCTCGCGGCCGGTGCTGGTGGTGTTCCAGTTGCTGTCCATGGTGAGGTCGCTGGTCACCACCAGGCGTTTGGCGGTGCCGTCGCGCTTGATGCCGATCCAGGCCGAGGAGTCTCGCAGGAGGGCGAGTCCGGCCCGGTCGCCGTCGCGCATCCCCTGGTGGTCGAGGATGACCGTGGCGGTGGAGGCGGGGCCCTGGATCCGGTGGGTCAGGGTGTTGCGGGCGGCGTAGAGGTCGTCGGTGACGGTCGCGGTCTGCAGGCGCAGCCCGTTGCCGGTGGACCACTTGGTGTTGTCCGGGTTGTGGTTCCACTCCCACCGCGGGGCGAGGCCCGGGCTGGTGAAGGTGTCGGTGACGGGGCCGGTCAGAGGTGTGACCTGGCGGGGCGGGGGCGGCAGGTTCGGCACCGGGTAGGAGGTTCCCCAGGCGCCGTCGAAGAGTTGGACGGTGGGCCAGCCGTCCGGGGACCAGGTGATGGGGGCGAGGGCGGGCATCCGGCCGCCGGGGTAGGCGTCGACGAACGCCATGTAGTACCAGTCGCCGTTCTGGGTCCGGACCAGTCCGCCCTGGTGGGGGACACCGCCTCCGGGGATCGGGCCGGGCAGGTCGAGCAGGAGCTGCCGCATCTCGTAGGGGCCGAAGGGACCGGTGGTGGACCTGAGGATGTACTGGCCGTTGGCCGGGCGGGTGACGAAGATGTAGTAGTTCCCGTTGATCTTGTAGAAGCGGGAGCCCTCCAGCACGCCGATGCTGGCCGGGGTGGTGAAGACGACCTCGTTGCGGACCTCCGTCGTCGCGTCCGGGGAGAGCTGGGCCACGCTGATGGTGGTGTTGCCGTGGGCGACGTACAGGGTGTCGTCGTCATCGATGAGCAGGCCCGCGTCGTAGTAGGCGGTGTCGATCACGGCGTGTCTGTTCCAGGGGCCTTGGGCGGCCGGGGCGGCGTAGAGGTAGGTCTTGGCGAAGTCGATCTGCCCGAGCCAGTAGAACGTCCGGTAGCTGGGGCGGTAGTTCAGCGAGGACGCCCAGATGCCTCTGACGTAGCCGCGGCCGCCGTTGAGGTCGTACTTCGCCCCGAAGTCCAGCACCGGGACCGAGTGGCCGGCGAACTCCCAGTTGACCAGGTCGTATGAGCGCAGGACGGGGGCTCCTGGTGAGTAGTGCATCGTCGAGGCGGAGCAGTAGTAGGTGTCGTCGACGCGGATGATGTCGATGTCCGCGAAGTCCTGCCAGATGACGGGGTTGGTGAAGGCGGCAGCGGCGGCCCCCGCGGTGTCCGGCGCCTTCGCGGCAGCGTGGGCCGATGGGGCGGCGCCGGTGAGGGCCGTGGCGGCGATCAGTCCGGCTGTCGTGGTCAGAGCTCTCCTGCGGCTGCACTCGCGTCCGGTCAAGGACATGCCAAATCAGTGCTCCTTGCTGGGCTTGGTTGACGCAACGGCTCCGAGAGTCAGGCCGGGCCGAGGGGTCAGCACGGTCCGGCTGTGACGCAGAAACAGATTCCGGTTCCGGTGGGCGGCTCCACGCGACTATGTTCGTGATATCGAACGTTGGTCGATTCTTCGACAAGCACGGATGATAGACGTCCGGTGAGGGCCGTCAACACCCTTCGTGCGGCGATTTCATGGGCTGCAATCAATCTGGCTGCTGGATCAACGACTTGCTGTGACACGTCTTGACGGCCTTGGTGGCCGCGCCTGCGGGCTGCAGATCAATAACACGCCGATTCAGGTTCTGCGCACGCGACTTGTACTACGTCGGCCTACCTGCGGCGACGTCGCACCGGGTAGGTGCTGAGATCGGCACTACCGTGGCGTAAACCTGCGTGTTGTTCGGAGGCGCACCCTAAGGGCCTACCGATCATCAAGGTGTTGCTTTCAGGTCGGCGGCTCGTTGACGTCGTATGCGCATTCCGGACGAGACGCGTGATCAACTTGCCGTGAGGTTCGCGGTGTTGTTCCCGCATCTGAACGAGCGGCAGCGGCGATTGCTGATGGCCGCGGAGGCCCGGGGGTTGGGGCATGGCGGTGTCCGGGCCGTGGCCCGGGCGGCGAGGTGAGTGAGACGACGGTCCGCAAGGTGTGTTCGATCTGGAGGCGGGCCAGTCCCTGCTGGGGCGGGTGCGGCGGCCGGGCGGCGGGCGTAAACGCGTCGCGGACCTCGATCCCGGGCTGCGAACCGCGCTGTTGCAGCGGGTCGAGCCGGATGAGCGCGGGGATCCGATGTCGCCGTTGCCGTGGACGACCAAGTCGACCCGCACGTTGGCGGTCGAGTTGACCCGCCAGGGGCACCGGGTTGGTGCGGATACCGTCGCCGCTCTGCTGCGGGAGGAGGGCTTCTGCCTGCAGGCCAACGCCAAGACGCTCGAGGGCTGTCAGCACGCGGATCGGGACGCCCAGTTCCGTTACCTCAACGAGCAAGCACGCGGCCATCGGGACACCGGGCAGCCGGTGATCAGCGTCGATGCCAAGAAGAAGGAGAGAGTGGTTTTCTGCCCCGGTTCGAGCCGGGACAGAAAACCACTCGCGGGCGTCAGCGCAGTTGCACGCTCAGGGTGCGGGCCTGGTAGCCGAGAGCGGAGGCCGCGGCCTGGGTGGCGCTGCCCCCGTGCTGCTTGTGCAGATCCGTGGCGAAGCGATCCACCTCGCGTGCCGCTTCCTGACGGTTGCCGCGCGTCAGGTGGGCCTGGGCGCGTGCGAGGTCCTGGGTGAGTGTCCGGGCGAAGAACGTGCCGGTGACGGCGGCCCTGTCGATCAGGCCCTTCAGCTGATTCTGGAGGGCGGCGATGCCGCCCGGTGTCCAGTGGGAGGGCACGGGCACCTTGGCGAAGTCCGTATCGGACGCGAAGTAGTAGCCAGGGTAGGACGCCTGGTTGTAGGCGGTCTGCTGGCGGGCCACCTCGACGCGGTACTGCGGGTCCTGCATGAGCGTGAACAGCTTGTGGTCGCTGTCCTGGGTATTGGTGTAGATGCGCAGGGCAGAGCTGTCGGTGGTGGGGACGGCCATCTCCTCGCGGTAATCGCCGAACAGGTCGGCGACCAGAGAGATGGGGCCCATGGTCCCGGTGGTCTTGAGGATGGTGCCGCGCTGGAAGTCGTAGAGCTCCGGCTGCTTCTTGAAGTTGTTGATCATCTGGGTGGTCATGTCAGGGGTGAAGCGGATACTGCGCTCGCTCAGCACCGGTGTGGTGGTGCTCAGCTGCTTGCCGGTGGCACTGAACAAACCGTGCTGGGACGTGCCTTCGGGCATGGAGGACCAGTTCTCCAGTCCACGGGTGTCCGGGTCGATGTCGCCGACCATGGCCTGTTCGGTGTCGAGGCCGCTGTAGGCGCCGAACAGGACCTTGCCGGTGGCCGCGTCGCGCATGGCTACGCCGTAGGGTGCGTTCTTCGCGTTCTCGTGGACGGTGTAGATCTCCAGACCCGGCCGGTCGGGATCGATGTCGGTGACGTGGATGCGGTCGCCGTGGCCCAGGCGGGCTGACTTGCCGGGGGCGTTGCTGCCTTCGGGCAGCGTGCCGTAGGAGCTGTAGAGCAGGCTGCCGTCGTCGTCGAGAGTCGCCGACCCATAGACGATTTCCTGGCGGCCGTCGCCGTCGACGTCGGCGGAAGTCATCGAGTGGAAGCCCTGGTCGGTGAGGGCCGCGTACTTGGGGTTGGAACCGTCCTTGGAGTGGGGGTCGTCATTGAACGGATTGGTCATCTGGCCCCAGCCGGAATCGGCGTACCACTGCTTGTGCAGTCGCTTGCCGTCCCAGGTGTAGGCGGCGACGGCGGTGCGGGTGTAGTAGCCGCGGGCGAAGACGGCGGAGGGGTGGCTGCCGTCGAGGTAGGCGACGGTGGACAGGAACCGGTCGACGCGGTTGCCGGGTTCGATGCGGGCCATGGCGTAGTCGCCCCACCGGAGGCCGTCGTCGGTGCGGCCGGGCTCGTAGTGCACGGTCTGCAGTTCGGTTCCGGTGGTGCCGTCGAATACCGAGAGGTACTCGGGCCCGTCGAGGATGAAGCCTTCGAAGTCGCGCAGGGCGTTCTTCGTTGAGCGGGCGGGGGCGTAGACGTCCATGAAGTAGTCGGCGAGCGACTTGGCGTCCTGCTCGGACAGGGGGTAGGAGTAGCGCGCGTCGATGCCGAAGCACTTCTCCAACGTGGCAGGCCACTGCCCGGACTTGACCTCTTTCTGGTTCTGCCAGTTGCGGAAGAGGTCGACGAGGTGCTGGTAGTAGCCGTCTTTGCTGAGCCGGTAGTCGTCGGTGCTGGTGTAGCCGGCCTTCCGGTCCGCCTGCGGCAGGGTGATGTAGCGCTGCGACTTGATGCTGCCGTCGCTGTTGTAGCGGATCGTCTTGGTGCCCGGTGCGGTCTTGAACATCATCTCCGAGCGGCCGTCACCGTCGAAGTCATAGACCAGGAACTGCGTGTAGTGCGCGCCCGCACGGATGTTGGGACCCAGATCGACACGGTTGAGGAGCGTGCCGTCCAAGCGGTACGTGTCGATCAGCACGCTTCCGGTGTAGCCGCGCTGGGAGTTGTCCTTGGAGTTGGACGGGTCCCACTTCACCACGTACTCGTAGGCCCCGTCGCCGTCCGTGTCACCGACGCTGACGTCGCTCGCGGTGTAGGTGTACTGCTCTCCGGCGGGTGTGACGCCCCCGGCGGGCTTCTTCAGCGGCAGGTCGTAGTAGTCGTGGTCCCAGGGGGTGACGGCGTCGCTCAGGTTGGTCTCGTGCCCGGCCACGACGGCCGCAACCCGGTAGGAAGCTCCAGCAGAGGCATCCTGATCCACATAGTCGGTGCTGTCGGTGACCGTGGCGATGCGCTTGCCGTCGCGGTAGACGTGGAAGTCCGCACCCGTCTGCCCGGCCTTCGAGCCGCCGGTCACCTCGTCGGCGAGCAGTCGCCAGGTGAGGAAGACGCCGTCACTGGTGCGCGCGGCGACCAGGCCTCGGTTGAGTTCTTCCAGCTGGATGTGTCCGGACCTGCCTGATGATGCAGCCTGCGCCGGAGGCGCGGCCTGGGCTGTCGGCAGGCCGGCACACATCAGCAACGCAGTCAGCGAGAGGGCGGCCACGCGTGGGCGTGATGGACGGAATCTCATGTGGGACGTGCCCTTTCTCCTGATGAATCGATTCATTCGCTGTAGGGAGAGACGCGTGCGTCCGCGTGAACAGGTGCGGGCGCGTGCGGACGGAAACGTCGTGAGGTCAGCTGAGCCGGGCGGCGGGTTCGGGGCGGTGCACGCCGCGGGGCCGGTAGCCCAGCGCGTCGGAGACTCCGGCGAGGTCGGACAGGTACCAGATGATGGCGAGCCACATCTCGGTGCCCTGCAGGCCGGGTTGAGTCTCGTGTGTGCCAGCAGTGGTGGGATGTGGGGCGCGGAAGGCGAACCCCCGGCCGTCGACCCAGTGCCCCAGCGCGTCGGTGAGCAGGCGCCGCGCGAGTGCGGTGACTTCCTCCGCGCGGTAGCCGAGGGCGCGGGTCAGCCACAGCGGGTGGGCGATGTCGAGGACGTTGCAGGCTGTCTGACGGTGCGCGCTGGTGTAGCGGGCGTCACGGGCGTGCGCGAGAACGCTGTCGATGACACGGTAGGGATGCGGTACGGGCAGGCCGTACTGGGCAAAAGTGCCGCGGCTGGCACGGTAGAAGCCGTTGACGGGCAACAGCAGTCCATCGGCCGGGCTTTCGGGGCCCCAGAGTCCCGTGCGGGGGTCGGCGCGGGCGAGGAGCCAGCCCAGGAGTGCTTCGAGGACTCCCGGCCGACCGGTCTCCTCGTGCCGACGGTTCCACAGCAACGCGGTCCCCAGCGTGTCGACCCAGTCGCCCGCGTACCAGGCGTCCTGCTGCCAGGGCAGCTCGTCCAGCGCCGTGACCACATCGGAGGCCGAGGCCTGGGCCACGGTGTGGACGGGATGGGGCAGGACACTGCCGAGGACGTCGAGGGCGTAGCCGACACACAGCAGGTGATAGGCAGTCGCCCTGTCGAACAGGCCGTCCTGGGAAGGCTGTTGCTCTCCGCCGGGACCGAGCGCGCCGATCAGTCCCGTAGCGGGGTCCTGCCAGGACTGCAGCCGCGCGATCTGGGCCTCGCGTGACAACGGATGGGGTGCGTGTCCCAGCAGCAGGTCGGCGATCTCGATCGCGTCGCACTGGGCGCGTACGGTTGGCTGCCCGCCCGGTGCGTCGACGAACAGGCCGCCTTGCACCGTCGGGGCGAAGCAGCGGGCGATGACGTCTTCGGCCTGCGCACGGGCGGTTTCGGCGAATGCGGAGACGGCAGCGGCCAGATCCGATGCGGTGACGGGGACGGCGGGGGCCGGTCCACGCCATCGCAGGACCCGGGCCGGGTTTCCGCCGACGACCGCGCCTGCGGGGACGTCCTTGGTAACCACGCTGCCGGCACCGACGACGGCGCCGTCGCCGACAGTGATGCCGTCCAAGACCACGACGTGCGAACCGATCCACACGTCGTTGCCGATGCGGATGCCCTGCGAGGTGACCGGCTGCTTGAACACTTCGGTGTCGGGGTCTTCGAAGCCGTGGTTGAAGGCCAGTAGCGAGGTGTGCGCGCCGATCCGCACGGCGTCGCCGAGAACGATGTCGCCCCGCACTACGGCGTAGGGATTGATGGTGCAATCGCGTCCGGCGTGCAACGTGCCGGTCACGTAGGCGCCCGCTGCGATGTAGCTACGTGGCCCCAGCTCCAGGCCGTCGTTCTGCACTGCCGCCAGCGGGGACAGGAAGCAGTCCTCGCCGAAGCGGTACGAACGGTTGGTCTGGCACAGGGAGTTCTGGTGCTGGCCTTGCTGGGTGCGGTCGTCGTCGGTGGCCTGCGTCCAGTAGTGCCAGGGGGAGTAGTCGAACAGATCGGGGCCCGGCGGCGGACCGTCCGGGTTGTGACGTTCGCTCATGTCATCCGTTCCGAAAGAGAACTGTTGGGGGTGGCCTGCGCCCGGTGGGTTGCCGTGTCGACGCGGGCTATTTGAGGCCGGTGGTGGCGATGCCCTTCACCAGGTACTTCTGTCCGGCGATGAAGAAGCCGACGACTGGTGCCAGGGAGACCACCGACATGGCGAACATCTGGCCCCAAGAGCTGGTGCCCTGGGAGTCCATGAACTGCCGCAGCGCCAGCGGGACGGTGTAGAGGCGGCTGTCGGTCAGGTACAGCAGCGGGGAGAAGAACTCGTTCCAGGTGGTGATGAAGGTGAAGATGCCGGTCGTGGCGAAGGCGGGCATGCACAGCGGCACCACGATGCGCCAGAAGATGCGGAACGGGCCGCACCCGTCGATCCGGGCGGCTTCGTCCAGCTCGCGGGGCAGTGCCCGCATGAACTGCACCATCAGGAAGACGAAGAAGGCGTTGCCCGCGGTGAAGTTCGGGACGAGCAGTGGCCAGTAGGTGTTCAGCAGGCCGAGTTTCGAGAAGAGGATGTACTGCGGTACGAGCAGTACGTGGGCCGGAAGCATCAGCGTGCCCATCATCATCGCGAAGAACAGTTTGCGGCCGCGGAACTGCATGCGGGCGAATGCGTAGGCCGCCATGCTGCAGGAGACCAGGTTGCCCGCGATGGCCAGGGCGGTGAGCAGCAGCGAGTTGACCAGATAGAGGCCGAAGGAGTGGTCCAGGGCGTTCCAGCCCTTGGTGTAGTGGCTGAAGTCGAAGTGTGACGGCCATAGGCTCAGGTCGCTGAAGATCTCGTCGTCCGGCTTCACCGAGCTGGAGACCAGCCACAGCAGCGGATAGATCATCACGGCTCCGACCAGACACAGCAACAGGTGTCGGCTGAACCGCTTCCAGGGCGTGGAGCCCACGGTCTCGATGTGGTCGTCGCTGTGTTCGCCCGGGCTGTCGGCTCCGCTGGTCTGTGGCTCGAGGGGAGTGGTGGTGGCGCTCATGTGTACTCCGTGGCCTAGTCGTTCTCGTAGAAGACCCAGTAGCGCTGGGCGATGAAGTTGAGGGCGGTGAACGCGGCGACGATGACCAGCAGCAGCCAGGCCATGGCGGAGGCGTAGCCCATGTTGAACGAGGTGAAGCCCTGCTGGTACAGGTACACGTTGTAGAAGAGAGTCGAGTCCGCCGGCCCTCCGGAACCGTTGCTGAACACGTAGCCCTGAGTGAAGGTCTGCAGCGAACCGATGAGGGACAGCACGAGGTTGAAGAAGATCACCGGGGTGATCAGCGGGAGCGTCACCGAGCGGAACTGGCGCCACTTGCCGGCGCCGTCGATCGCCGCGGCCTCGTAGTAGGAGACCGGGACCTGCTTGAGCGCGGCCAGGAAGATGACCATCGGCGCGCCGAAGGTCCACACATGCAGCCCGATCAGCACGCTCAACGAGGTGTCCGGGTCCGACGTCCAGGATGGGCCGTGGATGCCGAACAGCTCCAGGAACTTGTTCACTGCACCGTTGCTGCCGAAGATGGCCCGCCACAGCATGACGACGGCGACGCTGCTGCCCAGCAGCGAGGGCAGGTAGAAGACGGCGCGGTAGACCGGCAGCCCCTTCACACCGCTCTTGAGGAGCATCGCCACGCCCAGGGCGACCGCCAGGGACAGCGGAACGGAGACGAAGGTGTAGACAAAGGTGACCATCAGCGAGTGGTGCAGCCGCTCGTCTGCGAACAATTCGCGGAAGTTGTCCAGGCCGACCCACTTGGCGGGCGTGAGTAGGTCGTAGTCGGTGAACGCCAGGTACAGCGAGGCGGCGAAGGGCACGACCGTGAAGAGCATGCCGGCGAACCACGGCGTGAGGAACAGGTAGGCGGCCCAGTTCTGGCGCTGTCCGCGCGGCCGTCGGCGCACCGGCTCGGGGCCGCCGAGCAGGGACTGGGAGTGAGGAGAGGACTTCGACACGGGCTCAACCTCCGATGATCGAGCGTGCTTTGCCGAAGAACTCGGCTGCGGCCTTGGACGGTGAGGATTTGCCGAACGCCACCTTGTCGCTGATCGTTCCCAGGGCCAGGAGGAGTTCGGCGCTGCCCTGGGGGTCCGGCGCCGGATCGACGAGGTCGAACTCGGCCAGGCGGAGCGTGTAATCGGATGCGATGCGATCGTCCTTGCCGAGCGTCGAGGCCACCTGGTCGGCCACCGACTTCTTGATCTGGGCACCCCGGCCGACGCCGAGTTCCTTGTTCGCCTTGGTGTTGTTGATCAGGAAGTCGAGAAGTTCGAAGGCCGCGTCGGGCGCCTTCGAGCGGGCGCTGACCGACCAGTGGCCCACCGGCTGCAGCTGGTGGCCGCGCTGATCGGCCTGGCTCTCGCCGGGGAAGAAGCCCATCTTCAGCGCGCCGTGGACGGTGGCATTGAAGGCGGCCAAGCTGTTGGAGGGAATCGGGGCGCTGGCCGCCAGCTTCCTTCCGACGGGGGTCTGTTCGGCGGCCAGCCCCAGCTCCTCGATGTCGTCGGCGCCGGGGATCGCTCCGGCGTCGCGCAGGTCGACCCAGGTCTGGAACCATTCCGCGATGGAGTCCGCGGTGAATGCGATACGTCCTTCGGGGGTCCACAGGTCCAGGCCGCGCTGGCGCAGCCAGACACCCAGGGCGAGGATGTCGTCCATCGTGTAGGTGGCGCCCCAGACCTTCTTCCCGCTGGCGCGGGTGACTTCCGCTGCTGTTTCCTTGAGCGTGTCCCAGTCCCAGGTGTCCAGGTCGGGGACGTCGACTTTGTACTTGGCGAACAGCTCCGTGTTGATGACCCAGGCGTTGGAGGCGACACCGAATGGGACCCCGTACTGGACGTTGCCGATCTTCCCGGCGTTGAGCACGCTCGGGGGGACTCCTTCGATGATGATGACCTGGCCTACGGGCAGGGGCCGCAGCGCCTTGCGGCCGGCGAAGTCGCGCAGTGTTTCCCGGCGCACGGCCAGCAGGTCGGGCGGGTTGCCTCCGGCGAAACGCACGGCGAGCTTGTCGTCGTAGGCGGTTCCCGACTGGTACTCGGTGGACACTTCGAGACCGGTAGACGAGCGGAACAGGTCCAGGGCCTTCTCCGTCATCTGCGCCCGGATGGCGTCGCCCCACCACACCATGTTCACGGTGTGGCCGTCCGAGGCGCCCGAGCGCAGTCCGCCGAAGCGGCTGCAGCCTGTCGCAGCGGCAGTTGCCGCGAGCCCCAGTCCCAGGACGGCCCTACGGCTGACGCCGGGCGACGCGATTGCTGTTCTGCGGCCGGACCGTTGCCCGACCACCCTCATGCGTTCATGGCGCATTGCTTTCGTTCCCCTTCGAATGCGATCGATGTCGCATCTTTCGCGCGGGGCTGGTTGTTGTCTAGGGTGGATGCATGAATCCGTTGGTAACGAAAACGTAATGAAGATGGCGGGCCCGAGGGGAGGACGGGGGACGCTGGATACAGGCTCCCGTGGCTTCAACCATCCCGTCGTGCAGGGGGTTTGCCCCCACCCTTCGTGTCCCGGGCCCGCTGAAGATCTTGGTTGGGGTAGCGACACAGGCCTGCCCGATGAGGTAGCACCTTGTGAGGTCGCACTACTTTCGTTCGAAAGTAAGCAGTCATGAACGTAGGGTTCGGTTGGCAGCCGGCTGCCAACCGAAGAAAGGGAGGGACGTGTTCGCCAACGAGCGCCAAGAGCAGATCCTGCGGCAGGTCCAGGAGCAGGGATCCGTGCGTCTGGCCGTTCTCGCACGGCAGTTCGGCGTCTCGATGGTCACCCTGCGAAGAGACGTCGGCATCCTCGCCGACAGCGGCCTGGTCACCCGGGTCCACGGCGGCATCACCAAGGCCAGCCCGGACGCTGACCTGCCCGTCAAGCAGGTCACCACGGACGCCAGGCAACTGGTGATCGGCATGCTCGTGCCGTCGGTGAACTACTACTACCCTGCCATCATCAAAGGCGCCCGCGACATGGCTGAGCAGCACGGCGCCCGAGTCGTCCTGGGAGTGTCCCGCTACGACATCGACGCGGACCGGGCCCGCGTCAGCCAGCTCATCGACAACGGAGCCTCCGGACTCCTGCTGACACCCAGCCAACACCCAGGCATCATCGAGGAGAAGTGGCTCGAGGCACTGCCCGTACCCACCGTCCTGGTCGAAAGGCACAGCGAACTGGGGCTTGACGTCTCCCACCTGGACACGGTCATCTCTCACCACACCCACGGCGCGTTCATCGGCGCCCGGCACCTGGCCGACCTCGGGCACCGCAAACTCATCCTGGCCACCCGCTCCAGCCCCTCCACAGCCGGCGTGCAGGGCGGATTCCACGCAGCGGTGGAGCGACTAGGCCTGGACGAGCCCATCCTGCTGAGCATCGATCACGACGGCCCCACCGAAGCACAGATCCAGCAGACCATCACTGCACTGCGCGCGGGCGCAACCGGCGCACTCATCCACAATGACGACGACGCACTGATGCTGGTCCAGCACCTGCGCGAAGCCGGACTGAGCGTGCCCGACGACCTGTCCGTGGTGGCATATGACGACGAGGTCGGAGAGCTGAGCGACCCACCCCTGACCACCGTGGCGCCGCTGAAGGAAATGGTGGGCCGACGAGCCGCCGATCTGCTCATCCAGCGGCTGACAGGCCCATACGACACCCCCGTCGAACACACTCTGCTGCTCCCCGAGTTGCGCGTGCGCGCCTCCACCGCCCCCTGCACTGACCGCCACGCCATCCGCCACCGGGCCCGAAACCACAGGCCGCCCCGGCCCACACGACCCGAGCCACACGCACGCACGAAGAAGGAAGAATGACCACCCACGGCACGGGCCGCCGCCCCGTCACTGCCATCGCCATGGGCGAACACGTCGCCGAACGGCTCATCACCCCCGTCATACGCCGCCGCCTGAACGCCCTGGCCAGCGTGCGCCCCGGACACACTGTCACCGAGTTCGACACCGTCGATCTCTCCGACGTCGAAGTCCTTTTCACCTGCTGGCACTGCCCGCCCATCACCGCACAAGTTCTGGACCGGGCACCCCGCCTCCGCGCCGTCATCCACGCCGCCGGCACCGTCAAGGACCACATCACCGACGCCTGCTGGCAGCGCGGCATCACCGTCACGTCGGCTGCCGCCGCCAACGCCGAACCGGTAGCCGAGTTCACCCTCGCCGCGATCCTCTTCGCCGGGAAACGCGTGGTCGACATCGCCCGCACCTACCAAGCCACCCGCAGGGACCACGCCTGGGACACGCGCTATCCAGATCTGGGCAACTACCAGCGCACCATAGGCATCGTCGGAGCCTCACGTATCGGCCGCCGCGTGGTCGAACTCCTGGAGCCGTTCTCCTTCAACGTCCTGGTCTACGACCCGTATCTCGCCGGCGACCTCCCTGGAGCCCGCACGAGCGACCTGGACGAACTCGTCGCCTCCAGCCACATCGTCTCCCTCCACGCCCCGGACCTGCCCGAAACCCGGCACATGATCGACGCCACCCGGCTAGCCGCCATGCGTGACGGTGCCACCCTCATCAATACGGCCCGCGCCGCCCTGGTCGACCAGAAAGCCCTCACCGCCGAACTGCTGACCGGCCGACTTCACGCCGTGCTCGATCACACCGCGCCGGAAGTCCTGCCCCCCGACTCCCCGCTGTACGGCCTGCCGAACGCCGTGGTTACCCCTCACATCGCGGGCTCGATCGGCAACGAACTCGCCCGCATGGCGCACCTGGCCCTCGACGAATTGGACCGCTACGCTCACGGCATCCCTCTGCAGCACCGCGTCGACCCCCACGCCCTGCTGCGCACCGCCTGAACCGTCCCGCCGAAACAACTTACGGAGATCCTCAAGAGGGCGGGGATCGACCCCGCGCCCCAGCGCACGGACCTTTCCTGGTCCGCCTTCCTCAAAGCCCAGGCCTCCGCCATCGTGGCCACCGATCTGTTCCATGTCGACACGGTCTTCCTGCGTCGCTGGTTCGTGCTGTTCTTCATCGACCACGGCACCCGACGCGTGCACCTCACCGGCGCCACGCGCAACCCGACCGGCCTCTGGATCGCCCAGCAAGCCCGCAACTACCTCATGGACCTCGGTGACCGCGCAGAGTCGATCAAGTTCCTCATCCGGGACCGAGGCGCCTACATCACCGACAGCTTCGACGCCGTCTTCCAGGCGGCCTGCATACGCGTGGTTCCCACACTGCCCGCCGTGCCACGGATGAACGCCATCGCGGAACGCTGGATCGGATCATGCCGACGCGAAGCAACCGACCGCGTCCTGATCACCGGCGAGCGCCACCTCCGCCTCGTCATCGGCGAGTATGCGGGGCACTACAGGCACCGACCGCACCGATCCCTCGGACAACGGGCACCAGACGGAAGAATCCGGCACCCACAGGCCTCACGGCCGATGAAGTCGTGGTTGAAGGAGATCGCCTTGCCGTAGCCCAGTTCGTAGGGCGAGCAGTAGAAGTCCTCGATGCTCTCGGAGAAGAGGCTCCCGTGCAGCGGCTGCTGCCCCTCGATCCCGTACAGAGGGAGGTAGGTGCGATAGTCGGCCAGAGCCGGGTCGGTGTAGATGGCAGGCGTCGGTGTCGCGATCCAGGCGCTCTCCATACTCGCGGTCGGATAGGCGAGCGCCCCGACGTGGACGAGGCCGAACTGCTCGCCGACGGTCATCAGCTCTTCCTTCACCGCCTTCGCGTGCTGCCACTCACCGACGAACTCGAAGCCGGGCTGGCCCGCCATGCCGTGGCGCAGTGCGCGGAAGGCCATCGCGTTCAGCGACACCGGGGAGGAGTGGAAGAACTTTGTCGACGGGATCGGCCCGCCGAAGACCTCCGCCACCAGAGCGCTCGCCAACGGCCCCTGGACCTGGTGGCGGAAGAGCGTCGGGTCGCCCTCCGTGCGGAACGCCGAGGAGGGGGCGGTGACGAACGTGACGTCGTACCCGCTCTTCTGGGCCCGGTACTTGACCCAGTTCTGCGCGGCGGGGACACCGCTGAGCGTGTACGTCTGCTCCGCGTCGCGCATCAGGATGCCGTCCGTGACGATGTTGCCGTCCTGCACCACGGGGACGAACTGCTTGGCCTGGCCGATCGCGAACCTCTTGTAGTTGTTCGCGCTCACCGCCGCCAACAGGCGGGTGGCGTCGGGTCCTTCGACGCACGTGTCGGACGTGTGGTGGGACAGGTCCGAGATCGTCGCACCGGTGTGCCACGCGTCCTGCTCCTGCCGTCACCCCGCGTATTCGGGCTCGATGACCTCCGGAGTCCACGGCGTGGGTTCCGGCTTCCACAGCAGCTTTACGGGCGAGCCCGCCTGGTCGATGCCGTCCTGGAGACTGGGTGCTGTCACGGGTATGTCCCTCTCACTTTCGCCTGTCAGCGAGACGTGGCTCAGGCATGTGCTGGTGTGCGACTCGTCGTAACCAGTGCGGGTGACGGCCTGACGATCTTTCGCCGTCGTCGCCCGTGTCACTACGTCTGCGTTCGGCCCTCTCCCGGGGCGGTCAGAACCGCGCCCGCGGACGTGGCGGACGGGGCATGGCCCGAAGCGTTCGTGGCAGCCGTGACTGTGGCGGTTGCCGCCTTCCGCGGGGTGCGCAGCAAGATCACGGAGACCAGGGCGGCGAGCAGGGCGAGGGCCGCGGCCACGATCAGGCACAGGCGGAGGCCATCGAGGAAGGCATCGCCCACGGCGCCCAGAGCCTGGCCGGTGCTGCCGCCCAGGTTCATCTGGGCGACTGCGCCAAGGCCGCCCGTATGCGCGGTCTCCACGATGCTCTGCCGTGTTGCCTCCGTGACCCCGGCGTCGGCGAGGTGACCGGGGAACGTGTCGAGGGCCCTGGCGGTGAGCAGCGCACCCAGGACGGCCGGGCCGAGGGCCCCGCCGACCTGCCGGAAGGCGTTGTTGCCGGCCGCGGCCATGCCGGCCAGATGGTGGGGCACGGAGGCGACCGCGGTGGCGGTCATGGGTGTCAGGACGCCGCCCATCCCCAGACCCAGCAGGGCCAGCCGCCAGGCGATGGAGGCGAACGAGGTGTCCGCGTCCACGGTGGTCAGCGAGAACAGCGAGCCTGAGACGACAAGCAGACCGACGGTGATCAGCCAGCGGGCGGAAACCCGGTGCATGAGACGTCCGACGGGCTGGCCGGCGACGATGGCCGCCGCGGTGACCATGAGGAGACGCCAGCCCGCCTGGAGGGTGTCGAGCTGCTGCACCAGGCCGAAGTAGAGGCTCAGGAGGAAGAAGAAACCGATCAGTGCCAGGAAGGTGATCATCGCGATGAGCGTGGTGGCCGTGAACGCCGGGCTGCGGAACAGCGTCAGATCCAGCATCGGGCTGTCGCTGCGCCGCTCGGCGAGGACGAAGGCGACACCGCTGACCACGGCGATGAACAGTGCCAGCATGACCTGTACGTCGGTGAAGGAGCCGGCACCGCCTTCGATCACGCCGTAGACCAGCGCGGTGATCGCCAGCGTGGCGGTGATCTGGCCCGGCCAGTCCAGCCGGCGCCCGTGCGGGGCACGCGAGTCGGTCAGTAGTCGCGCGGCGAGGACCATGGCGGTCAGTGAAATGGGGATGGCCAGCAGATAGATCCACCGCCACGCGGCGTGGTCGAGGATCACCCCGGCGATCAGCGGGCCCACGGCCAGCGCCACCAGGAGCGAGGTGGCCCACAGGCCGATGAACTTACCCCGCTCCCGGAAGTCGGGCACCGCGTGGCTGATCAGCGCCAGTGTGGTCGGCAGCAGCGCGGCCGCGCCCAGTCCGGCGAGAGCCTGGCCGATCCACAGGACCTGGATCGACTGGGCGGCCAGCGCGACTGCGGCGCCGACGGCGGAGAACAGCAGACCCGCCTGGAACACCTTCTTGCGCCCGTGGACGTCTCCGAAAACACCGGCGGTCAGGATGAACGCGGCCATGGGCAGGACGAACGCGTCCTGGACCCAAGATAGTTGGGCGGTCGACGCGTCCAGCGCCGCCTGGATGGCGGGCAGACTCACGGCGACGGTGGTCACCGGCAAGTAGGCGACGAACACGCCCAGGCAGGCCATAACGAGCGTGGCAGCCCGCCGGTCGGTCGGCCCGCTCGCCGATGGTGTGACGTTCACGAGAACACTCCTTTGCGGCGCGCCGCGCCGCGGTTGACATCTGGCGAGGATCGGTCCGGCCAAGTGCCGGTTCCTCAGCAGCCGCGACCTGCGAACCGGCGCCGTCCCGCACGTGAGGTTCGGGCCGGGAGGCCCTACCTGTCCTTCGGAGCCTGTCCTTCGGACGAACCCGCGCCCCAGCATCGACGGAGCGGTTCAGTATCAACAAAGAACCAGCTGGAATCGACGAGAAACCGCTACTAAATCCCGCTCGGTGTCATACTTCCGCCGTGACTGACGATATTGACATGCAAATCCTCCGCGCGTTGCAGTACGCCCCGCGAGCTCCGTTCCGGCTCATCGGCGACGTGACCGGGGTTTCGGAGCAGACGGCGGCCCGCCGCTACTACGCCCTTCGCCGCAGTGGGGTGATGCGCGTTGTGGGTCTGGTCAACCCCGCCGTGTACGGAGAGGCACAATGGGTCGCTCGTATCCGCTGCCGCCCCGACCGTGTCGGCCCGCTCGCCGACGCTCTCACCCGGCGGTCCGACATCGCCTACGCCAGCATCGCCTCGGGCGGCTCGGAGATCATCTGCATCATCCGGTCACCGCTCCAGGCTCAGCGCGATGACATGCTGCTGCGGCAGTTGCCCAAGTCCGCTTCCGTGCTCGACGTGAGCATCGACCTGCTCGTCCACCCTTTCGGCAGTCCTGACACAGCCGGCTGGACCGGTTACGGCGGACACCTCACGCCCGAGCAGAAACAACGGCTCACCATCGGCCGTCCCCCCGCCCCGACCGGGCCTCTCCTGCCCCCCACTACCGAGGACACCCCACTCCTCGACGCCCTCGCCGAGGACGGCCGCACTACCCACACTCAGCTCGCCGACCTCACCGGCTGGTCCAAAGGCCGCGTAGCCCGCCGGCTGGAGGCCCTGGAAACGTCCGGCACGCTCTCCTACGACATCGACCTGATTCCCGAACGCCTCGGCCGCCACCTCAACGCCACCCTCTGGCTGCGCGTCGCCCCAACCCATCTGGAGCGCACCGGAAATGAGATCGCCCGCCACGACGAAGTCGCCTTCGCCGGAGCCACCAGTGGCGACCACAACGTGATGGCCATCGTCGCCTGCCGCGACGCCGAGGACTTCTACCGCTACCTGACCACCCGACTCGCCGCCATTCCCGGCATCGACGGCTACGGGGTCAGCATCAGGGTCCGCCGCCTCAAGCAGGCCGCCTCCCTCATCTCCCACGGCCGCCTGGTCCATCCCGCACTCGCGTAGACCCGGCTTCGCGTCGGCCCGCGGTCGGCCACTCCGGATTCCGGCTGGACCCAACGCTGTCTCCCCCATGGCCGGATTGAAGCGCGGGAACCTGAACGCGGGTCGTGAGCCTGAACGTGACAGCCTGAGCACTCACAGCCGCTGTCGGTTCAGTCCCCTGAGTATGGCCCGGACGAAGGCCGCATCAGGGTCGGGCGATTGGTACCAACGTCTGCCGCAGCGCAACAAGGGCGTCCGGGGCCGTCTGAGCATCGTCGTGTGGCTGCTCGCCGCCTGGTGGCAGGCATTGGGCATCTCGTCGCGAGGCTGACGCCTCGTGGTGACGGACGGGGATCTGCGATGAGCCGCTTCAGCGGCATTTGCCAGTAGGTGATCAGAAGGAAGCGTCGACCATGACCTCAGTGGTCCCTACCTTGTTGATCGGGATGAGCGAGCCATTCGAAGGGTTGGCTCACCAGGGGTGTCGGGTGTGGCTCTCAGTGGTCTGCCGTCCGTATGGCTTCGTACGATTCGCCGCCCGACACCCCCCGACGACTCTGCTGCTGATTAGGAACGCTGAGTAGGGACTCGCCAGCGAGGTCGTCTGTGCTGCATGTAAGCAAGCGGCCCGTGGAGAGCGCGTGACAGCGATCTGGGCCGGCATCGACGCCGGCAGGACCCATCATCAGTGTGTGGTGATCGACGACACCGGGAAGCGGCTGCTGTCGCGGCGAGTGGCAAACGACGAGCCGGAACTGTTGAAGCTCCCTGTTGATGTCCTCGCCCTGGGTGACGAGGTCATCTGGGGCATCGACCTGGCCGACGGCGGCGCCGCCTTGCTGATCGATCTGCTTCTCAATCACGGCCAGCACACGCTCTACATCCCGGGCCGAGCCGTCAGCCGTGCCTCCGAGGGCTACCGGGGGCGAAGGCAAGACCGACGCCAGGGACGCCGCGATCATCGCCGACCAGGCCCGGATCCGCCGGGACCTGCAACCCTTGCGGCCGGGCGACGAACTCGTCGCCGAGATCAAGATAGTCACCGGCCATCTCACGAACACCGGCCCGCTGGTCCTGCTGACCGGCTACCTGACGCCAGCCGCCATCCGCAGGATCGGTGCCAGGAGGCTGGAGACCTGGCTGAGCAACCGCAAGGTCCGCGGTGCTGCTCAGCTCGCCGACGGCTCTGGGGGGCTGCCGAGAGCCAGAGCACACCACCGTGACCAGGGAGAAGCCGGCGGCCCAGCTCGTGCACACGCTCGCCAGGGAGGTGATGCGCCTCAACGAGCAGATCGCCGAGACCGACAAGCTCATTGAGGCCCGATTTCGCGAGCACAAACACGCTGAGGTGATCGCGAGCATGCCCGGCATCGGGCCCCTGCTCGGCGCCGAGTTCCTCGCGGCCACCGGCGGCGACATGATGGCTCTCGTCAGTCCGGACCGCCTCGCCGGGTTCGCCGGCGTCGCCCCGGCTCCGCGTGACTCGGGCAAGATCAGTGGCAATCCGCAACGGTACAGACGTTACAGTCGGCGACTCCAGCGCGTCTTCTACACCTCCGCGTTGATCAGCATCCGCTGCTGTGAAGAATCCTGCCGCTTCTACGACCGCAAACGCGCCGAAGGCAAGCGGCACACCCAAGCCGTCCTCGTCCTCGCCCGCCGCCGGGTCAACGTCCTGTGGGCCCTGTTGCGCGACGGACGGTGCTACGAACCCATACCCTCCGTCACGAACGCTGCTTGACAAAGAATCGCACATCCCTGGATATCCCCACCGGATGGTGTCGCCGACGCCTATCTGGCGGAGGGATGAGGACTCTGTCAGGCCGAGGGACGCCGATCGGTCTTCGTCTGTAGGCGAACATTTCCCCTACACGAGATACGATATCTTGCATTCCAGGTGGCGTCGGCTCTGGAGCACAGGCATCGATGGTCGACATCAGCAGACTCAGCTGGCGAAGGGGCGAGCTGCGCAGGCTTTCCGTCCGACATGGCAGAGGACTTTGATGGGCAACGGCACGGCGAGCGACGTCTCGGTCGAGGTCTCGCTGGAGAGGCCCAGGAAGCTGGGCGACATCGTGCTCGACCAGGTGCGCGAGCTGATCGTCGGCAAGCGGCTGCCACCTGGGGAGCGGCTGAGCGAAGCCAAGATCGCCAAGATGCTCGGGGTGAGCAAGACGCCGGTGCGCGAGGCGCTGCTCCAGCTCCGCATGATCGGGCTGGTCTCGATGATCGACGGCAACGCGCATGTCGTCGTCCCTTCGGCGCGCCTGATCCGCGAGGCGTACGAGGTCAGGGCGGGACTGGAGGCGCTGACAGCGCGCCTCGCCGCCGAACGGGCCGCCCCCGATCGGCGGGCGCAGCTCCTGCCGCTGGCCGAGGCATCGCTGCAGGCCGCACGGGACAACGATGCCGCGGCCTTTCGCGGGCTCGACCAGGAGTTTCATCACGCGGTGGCGCTCGCGTCGAACAACGCGACGGCACAGCAGCGCATCGACGAAACCCTGGTGCTGTGCCAGACGCTGCGGCGCCGGGACGTGCTCACCGGCTGGGACTCGCAGCTGTGCGGGCAGGCCCACGTGGCCATCGCCGAGGCGATCAACTCGGGTGACGCCGAGGTCGCGTCCCGAGAGATGTACGGCCACATCAACTACGTGATGGACCGGGTTCTTTCCGCCCTCGCGGGCCAGCAGCAGGGTGCATAGGCGATCGCCCACAGAGACGCCTGACCACTACCCTTCCCGGCCCGGCCGGGAAGGGTAGTCGTATCCGCGTCCGGGATCAGCCCTCCAGACGCCGGCCCAGGAGTCGGGCCCTCCCGTACACCGGTGAAGCAGAATGCGCCCCGGCGCGCCGCCGGGCCACTTGAGGCAGCAGGTCGTGCTGCCCGAGCCTCAACAAACCCGTGCCGCCAGCCTCAACATTGAGGCTCTGACCAGCAGTTTTCGCTGAAACCGTGGCATCGGCGCCGTTCTCCGGCGCATTCTGCCCCGGCGGGTCGTGGTCGGCGTCTCGCCTCCGTTGACAAGTGCGAGATACGAGATACCGTATCTCGCCAGAACGAGATGCGAGATACCGGATCTCGATGTATGCAAGGAGCAGGCGTATGCGACTGGCGAGCATTGTCCGAGAGGGACGACCGGTTCCCGCGGTCGTCGGTGACCGTGGCGTGGCGGCGGTGGAGGACCTCGCGCCTCAGCTGCCGGCGGACGCGATGGCGCTGCTGGACGAGAAGACCTGGAGCGAGGTCACCGCCTCGGCTGAGCGGGCCAGCTCGGAGGTCTTCGCTCCGGCGGACAACGTGGTGTTCACCGCGCCCTACCGCCGGCCCCACAAGATCTGGGGCATCGGGCTCAACTACCGCGACCACGCCGCCGACCTCAGCGAGACCGCGCCGGACCAGCCCGCGTCGTTCATCAAGGGCGACCACACCATCGTCGGCCCCGACGAGCCGATCGTGATTCCGCGGCAGAGTGAGCGCACGACGGTCGAGGCCGAGCTGGGAATCGTGATCGGGCGGTACTGCCGTAACGTCTCAGAGGCGGACGCCCTCGACTACGTCTGGGGTGTGACGACCATTCTGGACCAGACAGCCGAGGACATCCTCCGGCAGAACCCCCGCTTCCTGACCCGGGCCAAGAACTTCCCCACGTTCTTCTGCTTCGGCCCCGAACTCGTCCCCATGGCCGAGGTCCTGGAGCGGTTCGGAGCGCTGGAGGACATCGAGGTGTCCACCGTCGTCAACGGTGACCAGCACCGGACCAACACCGTGGCCAATATGACCCACCGGCCGGCCTCACTGATCAGCTTCCACAGCCAGATGATGCCGCTGTATCCCGGCGACATCATCTCGACCGGCACCCCGGGGGCGATCGTGGTCGCCGACGGCGACCTGGTCGAGGCCGTCATCCCTGGCATCGGGCACCTGAAGTCGACAGTGCGGGCTGAGTCGTAACAGCCAAGCCGACCAACACCGTTCCGTCCTTTCCCAGGAGTTTTTCATGGATCTCAACCTGCAGAACAAGGTCGCGCTGGTCCTCGGCGCCGGAGGCGGCCTCGGCGGTGCGATCGCCGACGCGCTGGCCGCCGAAGGAGCCAAGGTCGCCCTCGCCGACATCAACAAGGAGGCACTGGACGCGGTCCAGGAGCGCGTAGGTGCCCGGACGGCGACGGCCGCCGTCCAGTGGGACCTCGGCGACCTCGACTCGATTCCGGGTCATGTGGCCGCGATCGGCGAGCAGTTGGGCCCGGTGGACGTTCTCGTGAACGTGACCGGCGGCCCGCCGCCCACCCCCGTCGCGGGCCAGGACCGTATGACCTGGTCGCGGTACTTCGACGCGATGGTGCTCTCCGTCATAGGCATCACCGATGCCGTACTGCCAGGTATGCGCGAGCGCGGTTGGGGCCGTGTCATCACCAGCACCTCAAGCGGTGTGATCGCGCCCATCCCCAACCTCGGCCTGTCCAACGCTCTCCGCTCCAGCCTCGTCGGCTGGAGCAAGACGCTGGCGCGCGAGGTCGGCCCGTACGGCATCACCAGCAACATCGTCATCCCCGGCCGGATCGCGACCGGGCGCATCACCCAGCTCGACGAGGCCAAGGCCTCGCGCGAGGGACGTACGGCGGCCGACGTCTCGGCTGAGAGCGTTGCCTCCATCCCGGTCGGCCGCTACGGAACACCCGCCGAGTACGCGGACATGATCGCGTTCCTCGCCAGCCCCCGGGCCGGCTACATCAGCGGCAGCACCATCCGCGTCGACGGCGGACTGATCGCCTCCGTGTGACATCCGTACGACAGCCCAGGCGTAGGCGCACCGCGCCGTAACGACCGGTGCGCTCGCGCCCCCCCTTCGGCCACCCTCACCGAACACCGCCCGACATCTCGCCATGTAGCCCTTCCGCGGCCGACCACCACGACGTCGGCCAGCACGACAAGGACCCCGCCATGCCCCGAAGCGAGCCCATGAGCCCACCCGAGACTGCCGACGGCAGACAGCTCTCCCTGAAGCGAGAGATGGGTCCCGGGCTGCTGTTGCTGTTCATCGTCGGCGACATTCTCGGGACCGGGATCTACGCGCTGACCGGCCAGGTTGCCGGCGAGGTGGGCGGTGCCGCATGGCTGCCCTTCGTCGTCGCGTTCGTGGTTGCGCTGATCACCGCGTGCTCGTACCTCGAACTGGTCACGAAATACCCGCAGGCCGCCGGCGCCGCCCTGTACGCACACAAGGCCTTCGGCAAGCACTTCGTGACCTTCCTGGTGTGCTTCGCCGTCATGTGCTCCGGCATCACCTCCGCGTCGGCGGCCTCGCGGGCCTTCGCCGCGAACCTGGTCGCCGGGTTCGGCCTCGACGTGGGTAACGGCGTCATCCTGCTGATCGCTCTCGGCTTCATGCTCCTTGTCCTCCTCGTCAACCTCCGGGGCGTCGGTGAGAGCATCAAGGTCAACGTGGTGCTGACCGCCGTCGAGATGTCGGGCCTACTGCTCGTTATCCTGATCAGCCTGTTCTTCATATCCGGCGGGGACGCGGACTTCTCCCGCGTGGTCGCCTTCGAGACCTCCGGCGACAAGAGCGTGTTCCTGGCGGTGAGCACCGCGACGTCGCTGGCGTTCTTCGCCATGGTCGGCTTCGAGGACTCGGTCAACATGGCGGAAGAGACCAAGGACCCGGTTCGGATCTTCCCGCGCATGATGTTCACCGGGCTGGGGATAGCCGGGCTCTTCTACGTATTGGTGTCCGTCTGCGCCGTCGCCGTGGTCCCGGTCGGACGGCTCGCCGAGAGCGAGACCCCGCTCGTGACGGTGGTGCAGACGGCCGCCCCCAACTTCCCGATCGCGGATCTGCTGCCGTTCATCTCGATGTTCGCCGTCGCGAACTCCGCACTGATCAACATGCTCATGGCCAGTCGGCTGATCTACGGGATGAGCAGGCAGGGAGTGCTGCCGCGCGCCCTGGCGAAGCTGCATCCGACGCGGCGTACCCCGTGGGCGGCGAGCCTCTGCACTGCCGTCCTGGCCTTCGCCCTCATCACCTTCGTCTCGCTCAACCCGGACAGCCAGGTCGTGGCCCTGCTGGGCGGGACGACCTCGCTCCTCCTGCTCGCGGTCTTCGTGATCGTGAACGTGTCCGTTCTGGTCCTGCGCAAGGACACGGCGGACGTGCGCCATTTCCGGGCAGGCCGCGTCCTCCCCGTCATTGGGGCGATCGTCTGCCTCTACCTGGTCCTGCCCTGGTCGTCCGGGCGCCCTGCCGGCCAGTACCAGATCGCGGGCGTACTGCTGGGACTGGGCGTACTGCTGTGGGCGGTCACCTGGTTTCTCCTCCGGGAGGTGCCCGCCCACCCGGCCGTGGAGGAGGACGAGATCCCCTCGCGCTGAGATCCGTGCGGCCCGCACTGGGCCGTACAGGCCGACTGGCAAGTCGGGCGGGTACGCCGCCCGTTGAAACGTCGCCTGCGGTGGCAGGCGTAAGGAGACTGAACTCCGGTGAATTCCACACTCGATCTCGCCGAACCGGCAGCCCGGCTGGCCGACATCAAGCCCTCCCCGATCCGCGCCATCTTCGACCGCGCGAGCGAGCTGGAACGCGCCGGAGAACGCGTCATCCACCTGGAGATCGGCCGTCCCGACTTCGACACCCCCGAGGTCGCCAAGCAGCGCGCGGCCCAGGCGATCGCGGACGGCAAGGTGCACTACGGACCCAACGCCGGCCAGCCGGAACTCCGTGCCGCCATCTCGCGCTACCTGGACCGGCGGCACAACCTCACCTACAGCCCGGATGACGAGGTCCTCGTGACCATCGGCGCCAACGAGGCGGTCTTCCTCGCCATCATGGCGTTCTGTGGCCCGGGCGACGAGGTAGTCATACCAGTGCCCGCCTGGTCCGCGTACGTGGCCTGCGTACGGCTGGCCGGCGCGACCCCGGTGATCCTGCCGCTCAGCGCCGACGACGGTTACCAGGTCAACCCCGACGCCCTGGCGGCCGTGATGACCGAGCGCACCCGCATGGTGGTCCTGTGCACCCCGCACAATCCGACCGGCGCGGTGACCGACCCCAAGCGGCTGGCCGGTGTCGCCGACGTCGTCCGGGACACCCGGGCGCTGGTGCTGTCCGACGAGATCTACGCCGAGTTGGTCTACGGCGGACAGCGCCACATCTCCCCCGCTTCGGTGGCCGACCTGCGGCACCGGACACTGGTCGTCGGCGGTTTCGCCAAGGCGTACGCGATGGACGGCTGGCGGCTGGGCTGGCTCGCCGGGCCCAAGGAACTCGTACGGCCCGCGCTTCGGATCCGGCAGTTCACCACCATCTGCCCGACGACGTTCGCACAGCTCGGCGGTGCTGCCGCACTCGATGAGGCGGGTGCCGAACGGGAAGCGATGCGACAGGAGTTCGAGCGCCGCCGCAACGTGGCACTGGAGGTGCTGGCCCAGCAGGACGTCCTCTCGCCCGGTGAGCCGGGCGGGGCCTTCTACCTGTACCTGAGCTACCCCGAGCGCCTCGGCCCTTCCGATGAACTGGCCTGGCGGCTCCTGGAGGAACAGCACGTCGCCGTCGTTCCCGGTACCGCCTTCGACTCCGACGGTGGGAAGCACGCCCTGCGCATCTCCTACGCCTGCGGCATCGACGACCTTCGCGAAGGACTCAACCGTCTCGTCGCCACCGTGCAAAGCAACTGAACACTCGGGCGCCCCATGGCGGGAACGACTACGGCCGCATTATGTGAGCCACCTGTGTACTGCGTAAGTACTAGCCCAGATTGTCGGCAGCTACACGACGACTGCACAGTCCCGTTCCGGGAGTCTGGCGAGGTCCCCGAGGCCAGAACGTGTGGAGACCTCGGCCATGGCTGCTTTCCTTTACCGACTGGGCCGGCTGGCCTTCCGGCGGCGCTGGTTCGTCGCCGTGCTGTGGGTGGTGGTGCTGGGCGCGGTCGGCTTCGGCGCCGCCACGGCGCCCGACGCACCCGACCAGAACAACTCCATGCCGGGTATCGAATCCCACAAGGCATTCGACCTGATGGAGTAGCGATTCCCCCGGCACCACCGCCAACGGGGCGAACGCCCGGGTCGTCTTCGTGGCGCCAAAGGGGGAGAAGGTCACCGCCGGCGACAACCGGGCGGCGATCGAGAAGCTGGTGGACGAGGCGGCCGACGGGTCGCAGGTTGCCGGTGCCGTGAGTCCCTTCCAGGCGAAGGGGGCGAGCCGCGACGGCACGACGGCGTACGCCACCGTCACCTTCGGGGTGACGGCCCACGATCTCACCGACACCTCCAAGGAGCATCTGGAGCACGCCATCGGTCAGGCCCGGAAGTCGGGCCTGACCGTCGAAGTCGGCGGCACCGCGCTGGCGGGCGGTGTCACCGCCGAGATCATCGGCGTCGGCATGGCCGCCATCATGTCCCTGGCCAGCACCCTGGGCCTGTCCTCCACCACCGGCACCCTGGCCACGATGCTCGGCCTCGCGTGCGGCCTCGACTACGCGGTGTTCATCGTCTCCCGCTACCGCGAGGAGCGAGCCAAGGGACATGAGCCCCAGGAAGCGGCGGGTCTGGCTGTCGGCACCGCCGGATCGGCGGTTGTTTTCGCCGGCCTCACCGTCGTCATCGCACTGGCCGGACTTTCCGTGGTCGGTGTCCCGATGCTGACCACGATGAGGTTGTCCGCCGAGCGGTCGTCATCGGCGTCCTCGTCGCCCTCACCCAGGTGCCGGCGTTCATTGGCTTCTGGCCGCGTGCAGTGCTCTCGCGCTCCGTCCGCAAGCGTGGCAGGAGCAAGGAAGCCGACGAGAACAACGGCGGCAGCCGCTGGGCCCGTGCGCATCGCGCGTGAGCTGCACGACGTCGTCGCCCACCACCTCGCACTGGCCAACGCCCAGGCCGGCACCGTCGCCGAACTCGCCGGCACGACCTCCTCGGCCCTGCTCGAACTCAAGGCCACCGTCGGCCTGCTGCGCCACGCCGACGACACGGACGAGCCCCTGGAACCCGCTCCCGGGCTCGCTCAGCTCCCCGAACTGACCGCCTCGTTCCAAAGCGCGGGGCTCACGGTCAAGGTCACCACCGAGGGGAACCCCGGCCGCTCTCCGCCAGCGCGGATCTCACGGCGTACCGCATCGTGCAGGAGGCATTCACCAACGTCACCAAGCACGCCGCCACCGGTTCGGCCGAGGTGCGGCTCGTCTACGTCGATGGCCTGCTGGGCATCACCGTCACCAACGAGGGAGGCAGAAAACCGCCTTCCCCTCCTGCCCCGGACAGCGGATACGGCCTCATCGGCATGCGCGAGCGCGCCGTCTCGGCCGGGGGCCGCCTGCGCGTGGGCCATCGCCCTCAAGGCGGCTTCGAAGTCTTTGTCGAACTGCCGCTGTGCCCCCTCGCCCCGGGAGAAGTCAGGCGGCGGGCTTGAGGGTGGAGATGTCGATGACGAAGCGGTAGCGCACATCACTGTTGAGGACGCGCTTGAAGGCATCGTTGATCTGGTCGGCGCGCACCACTTCGACCTCGGCGCCGATGCCGTGCTCGGCACAGAAGTCCAGCATCTCCTGCGTCTCCGGGATGCCGCCGATCAGGGATCCGGCCAGGGAACGGCGTCCGGCCAGCAGGGAGAAGACTCCGGCGGAGATGGGCTGGTCGGGAACCCCGAGGTAGACCATGGTGCCCTCGGTCGTCAGCAGGTTCAGGTGGGCGTCGACGTCCAGCGGGGCGGAGACCGTGCAGATGATGAGGTCGAAGGTGCCGGCGAGTTCTTCGAAGGTGGTGGGGTCGCTGGTGGCGTAGTAGTGGTCGGCGCCCAGCTTCAGGCCGTCGTCCTTCTTGCGCAGGGACTGCGACAGGACGGTGACCTCGGCGCCCATTGCGTGGGCGAGCTTGACTGCGACGTGGCCGAGCCCGCCCAGGCCGATGACGGCGACCTTCTTGCCGGGGCCCGCGTTCCAGTGCTTGAGCGGGGAGTAGGTGGTGATGCCCGCGCACAGCAGCGGTGCAGCCTCCTGGAGGGAGAGTCCCTCAGGGATGCGGACAGCGAAGTTCTCGTCGACGACGATGTGGCTGGAGTAGCCGCCCTGGGTGGGCTCGTCGCCCCGGTAGCGGTCGATGTCACCGTAGGTCTCGACCGATCCGCCACCGGTGCAGTACTGCTGCCGGCCGTCCGCGCAGTTGTCGCAGCGGCCGCAGGAGTTGATGATGACGCCGACGCCGACCCGGTCGCCCACCTGGTGGGCGCTGACCTCGGATCCGGTCCCGGTGACGATACCGGCGATCTCGTGGCCGGGGACCATGGGGAACAGGCCCTTGCCCCAGTCGCCGTGGACCTGGTGGATGTCGCTGTGGCAGATTCCGCTGTAGTGGATCTCGACCATGATGTCGTGGGCGCCGAGGTCCCGGCGCTCGATCGTGGTGCGGGTGAGCGGCTCTCCGGCAGCCGCAGCCGCGAAGGCAGTGACGGTGGAAGTCACGGTCCGGTCCTTTCCAATGGTGCTGGGGGGTGTGGCTGGGCGGTCGCGGTCAGCGCAGGGTCTTGTGCAGGGCGGCGATCGCGGGGGCGTAGGCAGCTTCGGCGATGGCGGCGACGGCCTCGTCAGGGGTGTGGCCATCGGCGGCGTCGAAGGTCGCGGACCAGGTGAGGAAGGCTCCACCGCTGTCGGCGACGGGCCAGACCTGCATGGTTGAGCGGTAGCCGCGCACCGGGAGCGGCGAGTCGATGATCTCGTACGTCAGAGCGCGCCGCGCGTCGTCGAGAGCCACGAGCCGCTCCTGGAACGTGCTGCCGTCCGTGCCGGTGAGGACGCGCACCGCGCCCGGCGCGAACTCGCTCTCGCCTTCTACGACTTCGCTGGACCGGATGGCTGGGTGCCATTCGGGTAGGCCGTTGAACCGCCGTACGACGGACCACAGTTCATCTGCGGAACTGGTGAACACGGAACTCCAGTAAGCCTCGGCCATGGTTCCTCCTCGGGACAGGATCAATTAGCGACAGAGCGGGGGGACGGGGTCTGCGGGTGGACCGTCGGTCCGAACGTGAGCCGCCCGCAGACCCGGTGGTGGAACCTCAGGCGGGCAGGCGCGTATCAAGGACGAAGCTGATCTCGATGAGCTGGCCCGGGAAGAACAGCGAAGCGACGCCCACCGTGCTGCTGGTGGGCCGGTGGGCGCCGAAGTAGGCGAGGTTGGCAGCGGCCATGGCCATGTTGTGCTCGGGCAGGTTCACCACGAACTGGGTCTCGGAGATGACCTGGTTGCGGGTGGCGCCGTAGTGGGCGAGGACCTTCTCGAAGTTGGCGTAGACCTGCTTGAGCTGGGCGTCGAAGTCGTCCGGGTGGAGGAAATCGCCCTTCTCGTCGTGGGAGAGCTGGCCGGAGACGTAGATGGTGTCGTCGGCCTTGATGGCCTGGGCGAAGCCGAACTCGTCCTCGCCGGAGACGTTGTGGCTGAAGGAGTCGATGGTGGTCATGGTGTTACTCCTGTTGCTGGGGGTCGGTTACCAGTTCTGGCGGGTGGGGGAGATGATCAGGTCGTTGACGGTGACATCGGCCGGCTGGTCGAGGGCGTAGACGACGGCGTCGGCGACGCTCTGCGGGGTGATGGCGATCTCGTTGAGTTCCTTGGCGGCCTGCCTGCCCACGGGGTCGGTGACCTTGTCGGCCCAGCCGGTGTCGATGACGCCGGGGCTGATGGTGCTGGCCTTGATGCCCTCACGGACCCCGAGTTCCTTGCGCATGCTCTCGGTGACGGCCTGGACGAAGAACTTCGTGGCGCAGTAGACACCGGCGCCGTCGCCGACCTGGTGGCCGGCCACCGAGTCCATGTTCAGGATGTGGCCGGAGTTCTGCCGGAGCATCACGGGCAGGACCGCGTGGATGGCGTTCAGATAGCCCCGGATGTTGACCTCGATCATCCGGTTCCAGTCGTCGAGCGCGCGGTCCTTCCAGTACGAGAACAGCATCAGGCCCGCATTGTTGACCAGGACGTCGATGCCGCCGTGGTTGTCGACCGCGAATTCGGCCAGTTCCTGGACCGCGTCGGCGTCCGTCACGTCGGTGGCCCTGGCCGTGACGGTGCCGCCGGCCTGGCGGATGTCGGCGACCAGCCGGTCGAGCCCGTCCTGGTCACGGGCGGCGGCGACGATTTTGGCACCCCGCGCCGCGAGGGCCTTGGCGGAGGCGGCGCCGATGCCGGAGGAGGCGCCGGTGATGACGACGATCTTGCCGTCGAGGTGGTTCATGAAGGGTGTCCTAATCCGTGTGTAGGGATTCCAGCCGGGCCCCGGCGGGGTGGCTGGTCTTGCTGATGGACGGGGTCGTGATGGCCCGCGGGTGCCGGGTGAATCCCTTTGTGTGTCCCGGCCCTTTGGAGGCCTTACGAGAGACCGGCGACAGCCGGCGCCCTCGGGCCACCACGACCCCGTCCGGAACCCGCGTTCGTTGATCGTCTTGGTGCGAGCCCTCCGCAGGGCGACCTCTTCCTTCCTCCCGAGCCCCGAGCTCTTCGCAAGACAGAGGCCCCTGCGGTCCGCTGGTGCCACGAACGGCTGGCGAGATGGCGGACCGACGAGTCCTGGGATTAGGTCGCCGCGTGGCCCGCACAGGCTTCTCACCTGCGCGAACAGCAACAGAACGGAGATGGATGTGACAGTGTTCTGCGGCATCGACTGGGCCGAGGACCACCACGATGTCGCCATGGTCGACGAGACGGGCACCCTGCTCGCCAAGCGCCGCATCGGCGACGACGCGGACGGCTACCGCCTGCTGCTCGGTCTGCTCGCCGAGTACGGCGACACCTCCGAGGCCCCGATACCGGTGGCCATCGAGACCTCGCGCGGCCTGCTGGTCGCCGTCCTGCGGACCGGCAAACGGCCGATCTACGCGATCAACCCGCTGGCCGCCGCCCGCTACCGCGACCGGCACGGCGTGAGCCGCAAGAAGTCCGACCCCGGCGACGCCCTGGTCCTGGCGAACATCCTGCGCACCGACATGCACGCCCACAGACCCCTGCCCGCCGACTCCGACCAGGCCCGCGCCATCGCCGTGCTCGCCCGCGCCCAGCAGGACGCCGTCTGGAACCGCCAGCAGCTCGTCAACCAGGTCCGCTCGCTCCTGCGCGAGTACTACCCGGCCGCCCTGGACGCCTTCCTCGGCAAGCAGCACGGCCTGGCCCGCGCGGAAGCCCGCACCGTCCTGGCCACCGCTCCGACCCCGGCCAGGGCGGCCCGGCTGTCCCTCCCCCAGCTGCGGGCCGCTCTCAGACGGGCCGGCCGACAGCGAGGCATCGACACTGAAGCCGAGCGCCTGCGCGACATCCTCCGTAGCGACCGCGCCCGCCAGCCCTCCGCCGTCGAGGACGCGATGGGCCACCAGCTTTCGGCCCTGATACGCCAGTTGGACGCCGCATGCCTTGCGGCCGACGAGCTCGCTGAGGCGGTGGAGACCCATTTTCGCCAGCACCCGGACGCTGAGATCCTGCTCAGCTTCCCCGGCCTCGGGGTCCAGCTGGGTTCCCGGGTGCTCGCCGAGATCGGGGACGACCGCGCCCGCTTCGCCGACGCCCGTGCGCTGAAGGCCTACTCCGGCTCCGCGCCGGTCACCCGCGCCTCCGGCAAGAAGCGGTACGTCGGGCGGCGTCACATCAAGAACAACCGCCTCATCGACGCCGGCTTCCTCTGGGCCTTGTCCGCCATGCGGGTGTCGCCTGGAGCCAATGCCCACTACAAGCGGCGACGCGAGCGCGGAGACTGGCACGCCGGGGCTCAGCGGCACCTGTTCAACCGGATGATCCGCCAGCTTTACCACTGCCTGCAGGCCGGGCGGCTCTTCGACGAGCAGCATGCGTTCACCTCCGGTCACTCAGCAGCCCTGGCCGCAGCGGCTTGACTTGTTAGGCACGCGAGATGTCTTTCGGGTGGTCGGCGGCGAAGGTCAGCGCTTGGTGCGGCGCCGTACGACATAGGCGTACTGCTCCGGCCAGCGGGTCTCGGCGCCGAGTTCGAGCGCGGCGTGCTGCGGCCAGTAGGGATGGCGGAGCAGTTCGCGGCCGAGCAGGATGGCGTCGGCCTGCCCGCCGGCGACGATCTCCTCGGCGTGGTGCGGGTCGGTGATCATGCCCACGGCGCCGGTGGGAAGGCCGGTCTCGGTGCGGGCCTGGGCGGCGAAGGGGACCTGGTAGCCGGGCCCGGTGAGGATGCGGGCGTCGGGGACCATGCCGCCGGAGGACACGTCGAGCAGGTCCACGCCGTGCGCGTGGAGCTCCTTGGCGAGGCGAACGGTGTCGTCACCGGTCCAGCCCTCGCGGTCGTCCTCGGCATTCTCGGTCAGCCAGTCGGTGGCCGAGGTGCGGAAGAAGACCGGCAGCTCGTCGGGCCACACCGCCCGTACGGCATCCACGACCTCCAGCGCGAAACGCAGCCGGTTCTCGAAGCTGCCGCCGTAGGCGTCGGTGCGGTGGTTGGAGGCCGGGGAGAGGAAGGAGTTGATCAGATAGCCGTGGGCGCCGTGCACCTCGGCCACCTGGAAACCGGCGGCCAGCGCGCGCTCGGCCGAGGCGGCGAAGTCCCGTACCAGCTGCTGGATTTCGTCGACGGTCAGCTCGTGCGGAACGGGCAGCCCGGCGAAGGCGACCGCGCTGGGCGCCACGGCCCGGTAGCCGCCCTCCGCCTCGGGCACGTACCGGTCGGTGAGCCAGGGCTTGTCGACGGACGCCTTGCGACCGGCGTGGGCGAGCTGGATGGCCGGGACCGAGCCGTGGGCCTTGATGGCCGCGGTGACGCGGGCGAACGCCTCCTGCTGGCGGTCGTTCCACAGGCCCAGGTCCCAGGGGCTGATGCGCCCGTCGGGACGGACACCGGTGGCCTCGGCCATGACCAGACCGGCGCCGCCGGCCGCCCGCGAGGCGAGGTGAGTGAGGTGGAAGTCGGTCGGTGCACCCGTATCCGGCCCGTCGGGGGCGGCGGAGTACATGCACATCGGTGACATCCAGACCCGGTTGGGTATCTCGAGCGACCGCAGGGTCAGCGGGGTGAACAGGGCACTCACGGTGGTTCTCCTCAGGGTGGGGGGCTTGGTCGGCCACGGGACAGTGGCCTGAACTTCGGGTGGTATGGGGGGTTGTGTGCGACGTTCTGCGTTCGGCCGTCGGATGTGCCGAGGGGTGTCGGCCCTGCCGCTGTGGGCTTCCACCCACCGCGAGCGGGCCATGCGCGCGGCGGGCGGCTGGTTCAGCGCGGGGCGAGAGCCCTCACGGCGTCCGCGATCAGCGTGTCTCCCGCGATGGCCTCGAGCGTCCGGCCCTCGCTGCCGGGTGCGTCGAGCAGGGCGAGCAGTACGGCGGCCACGTCCTCGCGAGTGATGCCGCCGGAGTCGGTGACATCGGCGAGCGTCACCGGCCGGTGGCCTCGGCATCCGTGAGCAGACCGGGTCGTACGACCGTCACGCCCAGCGCGGTGCGGGCGCGCACCGCCTCCTCGGCCGCGGCCTTGGCACGCAGGTAGGCGCGGAAGACCGGGTCGAGGGTGTCGTCCCGCGCCCGCAAATCGGCGCCCATGGCGGAGATCAGCAGGTAGCGGCCGACCCCGGCGGCCTCGGCGGCGTCCGCCAGCAGGATCGCTGCGTCGCGGTCGACGCTCTCCTTGCGCGCGGCTCCGCTGCCCGCTCCGGCTCCCGCCGCGAACACCACGGCGTCCGCGCCGTCCAGGTGCTTCGCGACCTCCTCGACCGAGGCCCTCTCCAGGTCCACGACCAGGGCTTCGGCACCCGCCACCGCCGGGCTCGTGGCCTGAGCCGGGTTACGGATCAGACCCGCGACGGAATCCCCACGCGTGGACAGGAGTCTTTCCAGGATGAGGGCGATCCTGCTGTGCCCTCCGGCCATGACGACACGCATGTGTCCGGCTCCTCCTGGCCCTCGCCTGCCGTCAGGCGTCGAGACGCATGTCGACGACGACGTTGATCTCGAAGAGCTGGCCGGGGAAGACCAGGCCGTCGACGCTCAGGCCGGTGGTGGCGGGGCGGTGGTCGCCGAAGTACTCCACGTGCGAGGCGGCGAGGGCGTCGACGTGCTCGCTCAGGTTCACGACGAAGACGGTGTCCTGCACGATCTGCTTGCGGGTGGCGCCGAAGTGGGCCAGGACCTTGTCGAGGTTGGCGAAGGTCTGCTTGGCCTGGGCCTCGAAGTCATCGGCGTGGAGGAAGTTGCCGTCCTCGTCGTGCGAGAGCTGGCCGGCGACGTAGATCGTCTCGCCGACCTTGACCGCCTGGGAGTAACCGAAGACCTGCTCCGCGGGGACGTCGAAGCTGAAGGACTGCAGGGTTGCCATGATGTTTCTCCTCTTGGTGTGGGTGATCGGGTGGGGAAACCGGGCCGTGTGGACACCCGGGGTTCAGGAAGCGCGTCGGCTCGTCGTTGAGGCCACGAGCTCGGCGACCGCGTCGGCAACGGAGGTCTCGCCGCTGGTGAGCTCGACGATGACGTGGTTCAGGGCGGGCTCGTGGAGAGCGGCGTCGATGAACGCCGCGACGTCCTCGCGGTGCACGTCGCCGTACTCGATCGCGGGACCGGCGGTGACGCGGCCGGTGCCGGGGGTGTCGAGGAGTGTGCCGGGACGGACGATGACCCAGTCGAGGCCGGTACGGGTCAGGTACACGTCGGCGGTCTTCTTCACCCGCATGTAGTGCTCGAAGCCCTCGCCGGCCTCACCGCCCCGCAGGGCGTCCGGGAACACGGAGACGAGCACGAACCGCGAGACCCCCGCACGGATAGCCGCGTCGGCGGCCTTCTCCAAGCCCTTGCCGTCAATCAGGGTCGTCTGCTCCCGGCCGGTGCCGTGGGCGCCGGCCGAGAACACCACGGCATCGTGACCGCCGAACTTCTGCGCCAGCTCCTCCACGGAGTCCTCGATGAGGTCCCCGAGGAGAGGGGTCGCGCCGGTGGCGCGCACGGTGTCGACCTGGGCGGGGTTGCGGTGCATACCGGTGACCGCGTCACCGCGGTCGGTGAGCAGGCGAGTGAGCCTGCTCCCGACGCCACCGGCGGCGCCGATCTGGAACACCTTCATGAGGGACCACCTCTCTTCTGGACTCGGACCTTCTGGACTTAGGTCTTCTGGGCTCTGGAGCACTTGTCTCAATGTTGACATTGGGCCAACGACTGAATGTTAACATTAGAGCATCGAGGAGGTAGAAATCATGAGAAGCCAGGGCGGGGTGGCCCCCGCGCGGCGCAGGGGCCTGGCCGACGAGGTCGCGGACCGCATCCGGGAGGCCATCTTCAGCGGGGCCTATGCCCCCGGTGCGCAGCTGCGTGAGGTGGAGTTGTCGGGCACGCTGGATGTCAGCCGCGGTCCGGTGCGCGAGGCGCTGCGGCTGCTGGAGCGCGAAGGCCTGGTCCACTGTGCGTGGCACCGTGGCACCACGGTGACGACACTGTCCCCCGAGGACGTCGCGGAGCTCGACAGCCTGCGCGGCGCGCTGGAAGAGCTCGCCGTGCGGCAGGTGATCGCCCACGCCTCGGACGAGGACCTGGCGGCCGTCGAGAAGACGGCGGGCCTCATGGAACGCGCCACGGACGAGCACGAAATGGTGCGCCTGGACATCGCCTTCCATGACGCGGTCTTCGCTGCCGCCGGGCATCTGCGCCTGCAGGATGCGTGGGAGGCCATCCGCTGCCAGGTTCACCTGTTCCTGCTGACCCGGATCACCCACAGCACCGAGGGCTACATCACGCGCATCCCGGAGGAGCACCGCGAGCTCGTCGCCGTCCTGCGCGCCCGCGACACCGACACCGCCCTCAGGCTGTTCGCCACGCATCGCCGTCTCGCCGTCGACGTGGTCGCCGGAACCACCACCCCGAAGTGACCAGCCGGCCATCAGCTGACTGATCAGCGGCATGACCCGGAGGGCGGAAAGGCAAGGCGCTTCGCACATGGCGGACCCCCGTCCGCGGAACAACCGGGTAGTGACAGATCGCCGTAGGCATCTCGGGGCCCGTTTCGCTCAGGCGGCGGCCTGTCCGCCCTGTGCCCGAACAGCCAGGTCGGACCAGTCGGCCCAGGTCTTCAGCCGGCCGGCGTACACCTGCGGAAGCATCTCGTTGCCCTGGGTGCCGAAAAAAACGCGCAGCGGCGGGTTGTCGGAGTCGACGACCTCCAGGAGGGCCTGGCCCGCGGCGGCGGGGTCGCCGAAGTCCACGGTCTCCATGAATGCCGCTAGGCCCTCACGAACGCCGTCGTAGGCGGAGATGGTGTCGGCCTGGACGGCGGACGAGCCGCCCCAGTCGGTGGCGTAGCCGCCGGGCTCGACCAGCGTGACCTTGATGCCGAGGCCGGCGACTTCCTGGGCCAGCGATTCGGTCAGTCCCTCCAGGGCCCACTTCGAGGCGTGGTAGCCGCCGAGCAGCGGCCAGGCGGCGACGCCGCCGGTGGAGGAGATCTGGACGATGTGGCCCGAGCCCTGTTCACGAAGAAAGGGCAGCGCCGCCTGGGTGACCCACAGGGCACCGAAGAGGTTGGTCTCCATCTGGTCGCGCAGCTGCTGCTCGCTCAGCTCCTCCACTGCGCCGAACAGGCCGTAACCCGCATTGTTGACGACCACGTCGAGGCGACCGAAGTGCTCCTTGGCCTGCTGTACGCTCGCGAAGACCGCGGCCCTGTCGGTCACGTCCAGCTCCAGCGGCAGCACCGCGTCGCCGTGGGTCGTGACGAGGTCGGTCAGCGAGCCGGCGTTGCGCGCGGTGGCGGCGACCTTGTCGCCCCGAGAGAGCGCGGCCTCGACGAAGCGGCGGCCGAAGCCGCGGGACGCGCCGGTGACGAACCAGATCTTGCTCATGGTGTTGCTCCGTTTTTGATGGTGCTGACTTTCAAGAGCCCGGCGGGAAAGCTGGGCGGGATTCCGGACGGCTGTGTGGTCAGTCCTGGAAGGTGCTGACCAGCGGTGCGATCTCGTCCAGGAAGCGGCGTACGGTCTCGGCGTCGGTCGGGGGCGCGTACAGCACCGCGCGGTTCACGCCGATCTCCTGCAGCTGGGCCAGGTGCGCGGCGTCGGGTGCGGTGCCGAAGACGGTCACCGGCACTTCGTCGGTCCGTCCGGCCTCGTATGCCGCCTCGCGCAGCTTGGTGATGCGGTCGGCCAGCTCGGCCACGGGCAGGCCGGCGTGCGGCATCCATTCGTCGCCGAAGTCGAGTACGCGGTCGGCCGCGCGGGGGCCGGAGCCGCCCACCAGTACCGGCGGTCCGGACGGCCGGTGCGGCTTGGGCCAGGACCACAGCGGTCCGAACCGCACGTGATCGCCGTGGAACTCGGCGATGTCCTTCTCCCAGATCTCGCGCATCGCCTTCACCCGCTCGGTCAGTACGCTCCAGCGGCGCGCGGGGTCGGTGCCATGGTTGGCGATCTCCTCGTTGATCCATCCGGCGCCCACGCCGAACAGCACCCGTCCGCCCGACAGGACGTCCAAACTGGCCAGCGCCTTGGCGGTGACGATCGGATCGCGTTGGGCCACAAGGGCGATGCCGGTGCCGACCATCAGGCTGCGGGTGGCGGCCGCGGCGTAGGTGAGGGCCACGAACAGGTCGTAGGTGTGCGAGAAGTGAGCGGGCAGCTCGCCCACCTCGGCGCGGGTGCGCTCGGTGGCGGGCAGGTGGGTGTGCTCTGGAAGGAAGAGCGACTCGAACCCGCGCTCCTCGACCGCTACGGCCAGTTCGTCGGGGCGGATTGCGAAGTCCGCGGGGAACATGGCGATGCCGAGCTTCATGGCTTTCTCCTGGCCGACCGGCGGCTGCGCGCCGTTCTGAGGTCGTAGTTCGCCGTCGACTCTATGCAGCGATCCCGAGGGTATCCATGACAGGAAAGCTCAGAAATTTACCTTAAAGTCTCATTCCTCACGGATATTCGGCCCCGGTAGGGTGTGAGTATGGATGTGCTCGCTGACGTACTGGCCGCTACCGGCTTCAAGGGCGTGCTGCTCACGCAGCTGCGTTCTTCCGGCTCCGGCTGGGGCTGCGCCATTGGCCAGCTCGACACCGCGGGCTTCCACCTGATCGCCGAGGGGGCCTGCTGGCTGCGGACCGCCGAGGCACCGCCGAAGCAGCTGGTGTCCGGAGACGTGGTGCTGCTGCCGCGCGGCAAACCGCACCAGCTCATCGGGGCGCCCGACGAGGATGCCCTGCCCTACGCGGAGCTGGAGGCCGCCCATCCGCCGAACCGCGCGGGCGTGGTCGACCTCGGCGGCAACGGGCCGGTCGTCCGGGTGGTGTGCGGAGAGTTCCACTACGTCGGCAGCACCGACAGTCATCCGGTCCTTTCGGCGCTGCCCGAGGTCATCCACGTGCCCCATATGAGTGCAGACCCGCAGTTGCAGGGCGTCATCCGGATCCTGGCCGCCGAGACGAGGAACGGGCAGCCCGGATCGCGGGCTGTGGCCACGCGCCTGACCGAGGTGCTCTTCGTGCTGACGGTCCGCGCCTGGCTCGAACGGGCCGACAGCGCCGACGAGACGGAGCCGTCGTGGCTGACGGCCCTGCGCGACCCGCGCATCGGCACCGCCCTGTCGCTGATGCACGAGGAGCCGCACCGCGACTGGACGGTGGAGAGCCTGGCCCACACCGCCGCGATGTCCCGTCCGGCATTCGCCCGCCAGTTCAAGGCCGTGGTCGGCCTCACCCCCCTGGCATACCTGTCCCGCGTACGCATCGACCTGGCCGCCCGCCTGCTGCGCGACACCGGCGACTCGGTCGGCGAGATCGCCCAAGCAGTCGGCTACAGCTCCGAGTTCGCCTTCTCCCGGGCCTTCTCCCGAGAACACGGCATCGCACCCGGCCGCTACCGGCGCAGCGCGTTGGCGGCACGCTCGTGACGGATCAGGCGCGGGCATCCACGTCGAACATGGACGCCTCGCCGGCCGCCTCTGTTCCAGACCCGCCCCTTGGTTCCTGTCGCAGGTCAACCTGATCGCCGCTCTGGCCCGCCCTCGTGGCAGGCCCAGGCCGGCCAGCCCTTCGGGGTAGAGGGCCCCATGCACCAGTACGTCCGCGTTCTGGGCCAACGTGATGACATTGAGGGAGGGGGCCGTGTCGCCGGAGCAGACGACGCTGCCGTGGTCGGTGTCGAAGCGATAGGCGTAGGCGGGGAACACGGCGCCGTGTGGGACGAGGACAGCGGTGACCTTGACGTCGTCGTCCTCCATGATGGTGAAAGGCCGCATGGCGGGCGCGGTGTTCGTCGCAGAGGCGGCGGTTGCGGCCGGTGGCAGGACATCGTGGACGTCCAGCAGTGTGGCCGGGTCGATGCCGGCGTGTTCGGCCATGAAGAAGGTGAGGGAGGCGGCGTATGCCTGCCCGGCCAGCGGACCGGGGGCGCCTGCCGCGGTGGAGGGGATGCCTGCGGGGCCGGGGCCGTACACGGCTACCGGTTTCCGGAATCCTTGATCTCCGGAGGCCCCGGCGGCCAGCAGCGGGAACGAGTAGTAGTCGACGACGTGGTCGGCGTGGAAGTGGGTCAGGAAGATGCCGGCCAGCGACGGCATCGACAGTCCTGCACGCATGTACTGGGTCACCGCTCCGCGGCCGCGGTCGACGACGTAGGTCCTGCCATTGACGACCAGAGCGGACGAGATGCCGTACCGGTTCGCCAACGGCGGTGGACCGCTGTTGGTGACCAGGAGGAAGAGGGACAGGGCCGCGCCGGAGGTGTCCGCCAGCGTCGCTGCCGCGGCCTGTGTCGTCCCCAGCAGCGGGATGGTGACCACGGCGGAGGAAGCCATGGAGCCCAGGACCGCTCTGCGGGATGTGCGCCCTGCCTTTCCCAACGGCGGGGTCGCCGGCAGGCCCCGGATCGACGGCTCACTATCTGTGGTTCGGCACATGGCAGGCGGCTCCTCTGCGGTGGGCAGGTCGTGACGAGGACGGGCACTGCGGGACCCCGACCCGCTTACTCCTCGCGCCGCGTGCTGCAGCCGTCATCACTGGGCGGAATGCTGCACACCGCTGCGCACAAGAAGGGAGAGTCCGTCACGCAACCTAAGGTGGCGTGTCCGCGCCCTTGTGCGGGGGATGCGCGGAACCACGCACCAGTCGACCAGTGCGTCACCATGTCGATCCGCCAGGTTGCAGAGGTTGTGGACGGTTGCGATCTGCTTGCCTGGTGGAGCCGGGCGTCCGGGACCTCGCTCATCCCGAGGCAGCGGATCAGGCGCTGCTCCCGCGGTTCGGCCGGCCCCGAACAGCAAGGTGGCGCCGGCCCTGTCCATCTGGTCACGCGCGGGCGGATGTGTGTCGCGCCCAGGGCGAAGTTCATGCGCATGGCGCCCGCGCCGCGCGGTTGGCGGGCGGGGCATCAGGGTCCCGCCGGGGTCCCGCCTTCATGTTCCGAGCACGGGAATCGGATGCTCCTTGAACCAGCGGGTGAGGAATTCGAGCAGGGCGCCGATCTTTCGCGGCGCGGTCTGGCCCGGGCCATAGATCGCGTACAGCGGTCGGTCGGGAACGGGGACCTCGGGGAGCTGGACCCGCAGGGCGCCGGACACGAGATCCTCGTAGGCCGACCGCTGGGGGAGCAGGGCGATGCCGCGGCCCTGGACAGCGGCCTTCTGGAGGGCGATGTAGGAGTTCGAGGAGAAGACCACGTTGCGGACCTTGTGCTGGGTGGAGGTGGGCCCGTGCCCGAGACGCCAGACAGGTTCGTTGACGTGCACCAGGCAGTCATGTGCGGCCAGATCGTTGGGGCGGGTGAGGGGGCCGTGCTGTCTGACGTACTCCTCGGAGGCGCACAGGGTGAAGGGGAGAGACGCGATCTTCTTGAGACGCACCCTGGAGTCCCGCAGGTCCCGCGTGTGCAGGGCGACGTCGAATCCGCTGTCCAGGAAGTCGTAGGTGCGCTCCGACAGCCCTCCCAGTTCGAACCGGACAGCGATCTTCGGATATGCCGCGGCGAAGGCGGCGATCGCGTCCCCGACGTCGAGACTCCCGATCCACTTGGGGCAGATGACGCTCAGGAGACCTTCCGCCCGGTCGTGCAGGTGCGCGATCTCGGCTTCTTCCGCTTCGACCTCGGCGAGGATGCGGGCGGCGAACTCGGAGTAGCGCAGACCGGGTTCGGTAAGGCTGACGGAACGAGACGTGCGGTTGACGAGCCGGACACCGAGCTGCCGCTCCAGCTCCGCGACATGGCGGGAGACGAGGGAGCCCGATGAGCCCAGCGTCCGGGCCGCTCCGCTGAAGCTGCCGAGCTGCGCGACGGTGACGAAGCTGCGCATCAAGAGCATACGGTCCATAGAAATCCTCCAGCCTGCCCTTGCCGGAAACGTCATCCATGCAGGTCACGCCGCATGCCGGTACTCGTGGAGGATTCCGCCGAGGCGATCGTGTCGACGTATCTTGAGGTGGGCTAACGTGTCCGGATCGTCGATCGGCGGGGGCAATGGGTGCAGCGGCCTGGCGTTCGCGATGCCCTGGTGTGGTCGGTGTCCGTTGTAGAACTGCTCGAACTCGCGCAGGGTGGGGAGGAGATGTCGTTGGTTCCAGATCAACGTCCGGTCCAGGAGCTCGCGGCGACAGGTCTGTATCCACCTTTCCGTGATCGAGTTCATCCTCGGTATCTGGATGCCGCTGAGCACGACCTCGATCCTCGCGTCCTTGAGGACGGCATCGAACAGTTCGGGGAACTTCCCGTCCCTGTCCCTGATCATGAACCGTGCCCGGCAGCCGAGGTCTTCGAGGTCCATGACGAGGTTTTTCGCCGCTTGGGCTACCCAGGAGGCGGTCGGATGCGTGGTGGCGCCCAGGACGCGGATCCTGCGACTGCTGTGTTCGATCACTACGAGCGCATACATCCGCATGCCCGACAGGGTGACTGTTTCCATGAAGTCGCAGGCCAGCAGGGCGTCAGCCTGGGTGCGAAGGAAGGTGGCCCAGGTGCTGGAGTTCCGCTCGGGTGCTGGGTCGATACCGGCCTCCTTCAGGATTTCCCAGACGGTGGACGCGCCCACCTTCACCCCCAGTACGAGGAGCTCGCCGTGCAGGCGCCGGTACCCCCAGCTCGGGTTCTCCTTCGCCAGGCGCAGCACCAGGACGCGGATCGAGCGCACTGTAGGGGGTCATCCCGGGCGTTTGTGCCGGCAGGAGGCGGCATGGCGGCGTGCGACGAGGTTGCGGTGCCAACGCAGTACCGTGTCGGGGCGTACGAGCAGCCGTGACCTTCGCAGGACGTGCCGTGGCAGCCGGTGTAGGAGCGCTGCCAGGAATGCCCGGTCGCTCGGGGTGAACCGGATCTTTTCCTTGCCGAGTTGGCGTTCCAGCACGGTGATCTGGTGGCGCAGGGCGAGGATCTCCGCGTCCTTGTCCCGGTCGGTCATCGGCAGCAGGCGAAGCATCGCAAACGCGTTCGACACACCCAAGTAAGCCAGTCGCAGCAGCACGATCGATCATCATGGCGTGCTGACGGCAGCTGCGCGAGAGCGTCGGCTCAGACGACCGCGGCCAGATTTCGGGAAACCCGATTCACCGGCCCCTACCAGGGCGGATGAGGTTTCTGGCAAGGGCAGCGTGCCAGCGAAGGACCGATCGCGGAGTGACCAGCAAGGCCACCTGGGTACGCTGCTGCTTGGTGACGAGCCGGAGCAGTGCCGCCATGACGGCTCTGTCGCTCCAGGAGAAGCGGGGCCGTGGCTGGGCACGGCGTGCGATGGCGAGTTGATGCCGGAGCATCAAGATCTCTGCGTTCTTCGAGGCATTCGAGCGGGCGAGCAGGGCAAGCCATCGGAAGGCTTGGCAGGCGAGCAGGTAGATCAGCCGTATGACCACGACCAGCACGCTGCCTCAAAACGGCTCGCCGCTCTTGAGATCTGGGCAGATCCGAAGCAGCAGGTCAGCCCGGGTGACATAATTCCCGGCCCCCACAACCTCAAGTATCCGGCACAGCCGCTTGACGCCGAAGGCGCCACGGTGATCGTCAACGAACTGGAAGCGACTCACCAGCTGGTCTCGCCCGCAAAATACTTCGCGGCCCTCCGCAGGATCTCCCGCTCGAGCTCGAGTTCCTTCACCCGCGCCCGCAGCTGCCGATTCTCCTTCTCCATCGCGCTGGCCTCACCGGCCCCAGGCCGGGCAGCCTCCTCTGCAGCCCGCACTCACGTGCGCAGCGTCTCGTGGTTGACACCCAGGTCCTTGGCTACCGACGCGTACGTCCCACCCGGGGTGGCCCGGTACAACGCGACGGCATCGGCCCGGAACTCAGACGAATACTTCGACGTCCCCAA

Protein sequences of DBSCAN-SWA_4

>NC_016582|10173037:10232574|10200654_10201797_+|WP_014181156.1|DBSCAN-SWA
MFANERQEQILRQVQEQGSVRLAVLARQFGVSMVTLRRDVGILADSGLVTRVHGGITKASPDADLPVKQVTTDARQLVIGMLVPSVNYYYPAIIKGARDMAEQHGARVVLGVSRYDIDADRARVSQLIDNGASGLLLTPSQHPGIIEEKWLEALPVPTVLVERHSELGLDVSHLDTVISHHTHGAFIGARHLADLGHRKLILATRSSPSTAGVQGGFHAAVERLGLDEPILLSIDHDGPTEAQIQQTITALRAGATGALIHNDDDALMLVQHLREAGLSVPDDLSVVAYDDEVGELSDPPLTTVAPLKEMVGRRAADLLIQRLTGPYDTPVEHTLLLPELRVRASTAPCTDRHAIRHRARNHRPPRPTRPEPHARTKKEE
>NC_016582|10173037:10232574|10227234_10228176_+|WP_043487999.1|DBSCAN-SWA
MDVLADVLAATGFKGVLLTQLRSSGSGWGCAIGQLDTAGFHLIAEGACWLRTAEAPPKQLVSGDVVLLPRGKPHQLIGAPDEDALPYAELEAAHPPNRAGVVDLGGNGPVVRVVCGEFHYVGSTDSHPVLSALPEVIHVPHMSADPQLQGVIRILAAETRNGQPGSRAVATRLTEVLFVLTVRAWLERADSADETEPSWLTALRDPRIGTALSLMHEEPHRDWTVESLAHTAAMSRPAFARQFKAVVGLTPLAYLSRVRIDLAARLLRDTGDSVGEIAQAVGYSSEFAFSRAFSREHGIAPGRYRRSALAARS
>NC_016582|10173037:10232574|10174330_10174783_-|WP_014181137.1|tail|DBSCAN-SWA
MLHARTVACAAAVAAAAGIALLPAQAQAAGSVHIYKIYYDSPGSDTRSNASLNGEYVQIKNSTSRGVSLKGWTVSDASNHRYTFGTYTLGAGKTVTVRTGSGSDTTYTKYQDRRAYVWNNVSDTATLRKASGTKVDACSYNSSRYDYKMC
>NC_016582|10173037:10232574|10217844_10218282_-|WP_014181172.1|DBSCAN-SWA
MAEAYWSSVFTSSADELWSVVRRFNGLPEWHPAIRSSEVVEGESEFAPGAVRVLTGTDGSTFQERLVALDDARRALTYEIIDSPLPVRGYRSTMQVWPVADSGGAFLTWSATFDAADGHTPDEAVAAIAEAAYAPAIAALHKTLR
>NC_016582|10173037:10232574|10213824_10215018_+|WP_014181169.1|DBSCAN-SWA
MNSTLDLAEPAARLADIKPSPIRAIFDRASELERAGERVIHLEIGRPDFDTPEVAKQRAAQAIADGKVHYGPNAGQPELRAAISRYLDRRHNLTYSPDDEVLVTIGANEAVFLAIMAFCGPGDEVVIPVPAWSAYVACVRLAGATPVILPLSADDGYQVNPDALAAVMTERTRMVVLCTPHNPTGAVTDPKRLAGVADVVRDTRALVLSDEIYAELVYGGQRHISPASVADLRHRTLVVGGFAKAYAMDGWRLGWLAGPKELVRPALRIRQFTTICPTTFAQLGGAAALDEAGAEREAMRQEFERRRNVALEVLAQQDVLSPGEPGGAFYLYLSYPERLGPSDELAWRLLEEQHVAVVPGTAFDSDGGKHALRISYACGIDDLREGLNRLVATVQSN
>NC_016582|10173037:10232574|10219958_10221206_+|WP_014181175.1|transposase|DBSCAN-SWA
MDVTVFCGIDWAEDHHDVAMVDETGTLLAKRRIGDDADGYRLLLGLLAEYGDTSEAPIPVAIETSRGLLVAVLRTGKRPIYAINPLAAARYRDRHGVSRKKSDPGDALVLANILRTDMHAHRPLPADSDQARAIAVLARAQQDAVWNRQQLVNQVRSLLREYYPAALDAFLGKQHGLARAEARTVLATAPTPARAARLSLPQLRAALRRAGRQRGIDTEAERLRDILRSDRARQPSAVEDAMGHQLSALIRQLDAACLAADELAEAVETHFRQHPDAEILLSFPGLGVQLGSRVLAEIGDDRARFADARALKAYSGSAPVTRASGKKRYVGRRHIKNNRLIDAGFLWALSAMRVSPGANAHYKRRRERGDWHAGAQRHLFNRMIRQLYHCLQAGRLFDEQHAFTSGHSAALAAAA
>NC_016582|10173037:10232574|10178193_10179450_+|WP_106436470.1|DBSCAN-SWA
MAGPLDVSPHWGGFLQVETVALRPYKLAAGPIGRRLSIVARVYGYPPDHNAGSEWMLHSMLRPLAERGHQVAVWLSHPQRTEKAYEIDGVRVVPFQEGMDFAAHAQKADVLLSHFENVPLVAGLARDRLIPLAVICHDNFATSFHNAAGADLVVYNSEWIRRDGEIFYARYPREFLPRNSIVVRPPVIAEEYRTQPGDCATLVNLNSDKGGELFWQIAAWTPGWKFLGVRGAYGQQIMPPPRLPNCEVLDSVPGQRMREHVYSRARVMLMPSLYESWGRVAVEAFASGIPVIAHPTPGLVESLGEAGIFAYRDDLNAWVHALTSLQDPDNWARASRRAKARSIELSAALDLDLWCDAVESLARTRIPNGFRRRALGTVVDASEMGRGPGSDAAARKTEPHVRHGAAEHGRTTTNSVDL
>NC_016582|10173037:10232574|10206368_10207364_+|WP_043487991.1|DBSCAN-SWA
MTDDIDMQILRALQYAPRAPFRLIGDVTGVSEQTAARRYYALRRSGVMRVVGLVNPAVYGEAQWVARIRCRPDRVGPLADALTRRSDIAYASIASGGSEIICIIRSPLQAQRDDMLLRQLPKSASVLDVSIDLLVHPFGSPDTAGWTGYGGHLTPEQKQRLTIGRPPAPTGPLLPPTTEDTPLLDALAEDGRTTHTQLADLTGWSKGRVARRLEALETSGTLSYDIDLIPERLGRHLNATLWLRVAPTHLERTGNEIARHDEVAFAGATSGDHNVMAIVACRDAEDFYRYLTTRLAAIPGIDGYGVSIRVRRLKQAASLISHGRLVHPALA
>NC_016582|10173037:10232574|10195299_10197003_-|WP_014181152.1|DBSCAN-SWA
MSERHNPDGPPPGPDLFDYSPWHYWTQATDDDRTQQGQHQNSLCQTNRSYRFGEDCFLSPLAAVQNDGLELGPRSYIAAGAYVTGTLHAGRDCTINPYAVVRGDIVLGDAVRIGAHTSLLAFNHGFEDPDTEVFKQPVTSQGIRIGNDVWIGSHVVVLDGITVGDGAVVGAGSVVTKDVPAGAVVGGNPARVLRWRGPAPAVPVTASDLAAAVSAFAETARAQAEDVIARCFAPTVQGGLFVDAPGGQPTVRAQCDAIEIADLLLGHAPHPLSREAQIARLQSWQDPATGLIGALGPGGEQQPSQDGLFDRATAYHLLCVGYALDVLGSVLPHPVHTVAQASASDVVTALDELPWQQDAWYAGDWVDTLGTALLWNRRHEETGRPGVLEALLGWLLARADPRTGLWGPESPADGLLLPVNGFYRASRGTFAQYGLPVPHPYRVIDSVLAHARDARYTSAHRQTACNVLDIAHPLWLTRALGYRAEEVTALARRLLTDALGHWVDGRGFAFRAPHPTTAGTHETQPGLQGTEMWLAIIWYLSDLAGVSDALGYRPRGVHRPEPAARLS
>NC_016582|10173037:10232574|10210446_10211295_+|WP_014181166.1|DBSCAN-SWA
MRLASIVREGRPVPAVVGDRGVAAVEDLAPQLPADAMALLDEKTWSEVTASAERASSEVFAPADNVVFTAPYRRPHKIWGIGLNYRDHAADLSETAPDQPASFIKGDHTIVGPDEPIVIPRQSERTTVEAELGIVIGRYCRNVSEADALDYVWGVTTILDQTAEDILRQNPRFLTRAKNFPTFFCFGPELVPMAEVLERFGALEDIEVSTVVNGDQHRTNTVANMTHRPASLISFHSQMMPLYPGDIISTGTPGAIVVADGDLVEAVIPGIGHLKSTVRAES
>NC_016582|10173037:10232574|10173037_10174264_+|WP_014181136.1|integrase|DBSCAN-SWA
MAWVERRGNKWRVRYWKPDGRAGSVPGSFETEPAARAHADQMNATAPEPAEPPHTPTPPAPRPPTPAPTTPTPPETVTVAEWADIWWQTMDVGDNTEAFYRSLLTRHILPRWGTTPLDQITPADVQIWLNRLRATYATATITGIRKLFAMIMTDAVDNQLLATNPVRPRRRGRGRIEPRHERPWADEHQVLTIAHRILRLAARNQCLLVITAAYTGMRWGELAALHRDNLDITNGHIHITADAGALHEVNGRLTLGHPKTYASVRTVTLPPFLTQLLATDLAASTRPFVFTTLHGKHLRRSGFQRRLWAPAAGGGRHNSETWTPVKQGLTFHGLRHSHKTWLIEDDVPDVAQARRLGHTMEDKNDDVYSHVAASIDARLLAGLETRWHRSIERYRHNRNDQGAPPITS
>NC_016582|10173037:10232574|10212303_10213716_+|WP_043487994.1|DBSCAN-SWA
MSPPETADGRQLSLKREMGPGLLLLFIVGDILGTGIYALTGQVAGEVGGAAWLPFVVAFVVALITACSYLELVTKYPQAAGAALYAHKAFGKHFVTFLVCFAVMCSGITSASAASRAFAANLVAGFGLDVGNGVILLIALGFMLLVLLVNLRGVGESIKVNVVLTAVEMSGLLLVILISLFFISGGDADFSRVVAFETSGDKSVFLAVSTATSLAFFAMVGFEDSVNMAEETKDPVRIFPRMMFTGLGIAGLFYVLVSVCAVAVVPVGRLAESETPLVTVVQTAAPNFPIADLLPFISMFAVANSALINMLMASRLIYGMSRQGVLPRALAKLHPTRRTPWAASLCTAVLAFALITFVSLNPDSQVVALLGGTTSLLLLAVFVIVNVSVLVLRKDTADVRHFRAGRVLPVIGAIVCLYLVLPWSSGRPAGQYQIAGVLLGLGVLLWAVTWFLLREVPAHPAVEEDEIPSR
>NC_016582|10173037:10232574|10189855_10191502_-|WP_014181149.1|DBSCAN-SWA
MSLTGRECSRRRALTTTAGLIAATALTGAAPSAHAAAKAPDTAGAAAAAFTNPVIWQDFADIDIIRVDDTYYCSASTMHYSPGAPVLRSYDLVNWEFAGHSVPVLDFGAKYDLNGGRGYVRGIWASSLNYRPSYRTFYWLGQIDFAKTYLYAAPAAQGPWNRHAVIDTAYYDAGLLIDDDDTLYVAHGNTTISVAQLSPDATTEVRNEVVFTTPASIGVLEGSRFYKINGNYYIFVTRPANGQYILRSTTGPFGPYEMRQLLLDLPGPIPGGGVPHQGGLVRTQNGDWYYMAFVDAYPGGRMPALAPITWSPDGWPTVQLFDGAWGTSYPVPNLPPPPRQVTPLTGPVTDTFTSPGLAPRWEWNHNPDNTKWSTGNGLRLQTATVTDDLYAARNTLTHRIQGPASTATVILDHQGMRDGDRAGLALLRDSSAWIGIKRDGTAKRLVVTSDLTMDSNWNTTSTGREVVSTSIHGNRIWLRATADIRPGTGREGHFSYSTDGTNFALLGAAFVLKNDWQFFMGYRFALFHHATRALGGSVHIRRFELATP
>NC_016582|10173037:10232574|10231816_10232128_-|WP_014181190.1|DBSCAN-SWA
MLVVVIRLIYLLACQAFRWLALLARSNASKNAEILMLRHQLAIARRAQPRPRFSWSDRAVMAALLRLVTKQQRTQVALLVTPRSVLRWHAALARNLIRPGRGR
>NC_016582|10173037:10232574|10218817_10219561_-|WP_014181174.1|DBSCAN-SWA
MNHLDGKIVVITGASSGIGAASAKALAARGAKIVAAARDQDGLDRLVADIRQAGGTVTARATDVTDADAVQELAEFAVDNHGGIDVLVNNAGLMLFSYWKDRALDDWNRMIEVNIRGYLNAIHAVLPVMLRQNSGHILNMDSVAGHQVGDGAGVYCATKFFVQAVTESMRKELGVREGIKASTISPGVIDTGWADKVTDPVGRQAAKELNEIAITPQSVADAVVYALDQPADVTVNDLIISPTRQNW
>NC_016582|10173037:10232574|10197070_10197988_-|WP_014181153.1|DBSCAN-SWA
MSATTTPLEPQTSGADSPGEHSDDHIETVGSTPWKRFSRHLLLCLVGAVMIYPLLWLVSSSVKPDDEIFSDLSLWPSHFDFSHYTKGWNALDHSFGLYLVNSLLLTALAIAGNLVSCSMAAYAFARMQFRGRKLFFAMMMGTLMLPAHVLLVPQYILFSKLGLLNTYWPLLVPNFTAGNAFFVFLMVQFMRALPRELDEAARIDGCGPFRIFWRIVVPLCMPAFATTGIFTFITTWNEFFSPLLYLTDSRLYTVPLALRQFMDSQGTSSWGQMFAMSVVSLAPVVGFFIAGQKYLVKGIATTGLK
>NC_016582|10173037:10232574|10176153_10176381_-|WP_014181140.1|DBSCAN-SWA
MEIAVAAAVGTACLAGVRLLRVWIGSRDRVRLARVRQQGISERVRALPPGCTLTERHHGEDVRVQVGTPRGGARG
>NC_016582|10173037:10232574|10174932_10175589_-|WP_014181138.1|DBSCAN-SWA
MNHSDAALDALLARADAGVLQAVTDNLDADRGSSLVHWHAVPTEDVPLPSPPDPYAAYQNIHIHGAITAAPVPEQAPGFLTGHPEPVADRTLAQLVADAYRNTELLDDILTLNSTTGETYLLRGQLEARITYLHGRLVKDGPGNGKGMNGSGATHLTLAVWGSACRIRRRLEQGEDYALAPGARMRAVALCTGVITAMETIRASLFTLFGIEVTAAMT
>NC_016582|10173037:10232574|10175585_10176161_-|WP_193383758.1|DBSCAN-SWA
MDKGRHGSPTLPVFLPGQRRPSVPAADDEVIREDFARYYQQHMPALIRFVMRYGADPYEAADAAQAAFIEAFRAWHLIHSPAAWLRKVAFRQYLRQAPIPQEELTGDVPDRPAFSCPLDKVVLQEEEKRVYTALAQLPMKQRQVMAWHLDGFPTSEIATELGIQPHAVRQNLARARAQLKDLLGLTSGGAQ
>NC_016582|10173037:10232574|10221251_10222364_-|WP_014181176.1|DBSCAN-SWA
MSALFTPLTLRSLEIPNRVWMSPMCMYSAAPDGPDTGAPTDFHLTHLASRAAGGAGLVMAEATGVRPDGRISPWDLGLWNDRQQEAFARVTAAIKAHGSVPAIQLAHAGRKASVDKPWLTDRYVPEAEGGYRAVAPSAVAFAGLPVPHELTVDEIQQLVRDFAASAERALAAGFQVAEVHGAHGYLINSFLSPASNHRTDAYGGSFENRLRFALEVVDAVRAVWPDELPVFFRTSATDWLTENAEDDREGWTGDDTVRLAKELHAHGVDLLDVSSGGMVPDARILTGPGYQVPFAAQARTETGLPTGAVGMITDPHHAEEIVAGGQADAILLGRELLRHPYWPQHAALELGAETRWPEQYAYVVRRRTKR
>NC_016582|10173037:10232574|10181906_10183280_+|WP_043487981.1|DBSCAN-SWA
MARVAVIGGGISGLGTALMLGRRGHTVTLFEQDARQAGEDLDRDFFHWDRPRVPQANQPHSLLAPVRTVLRAEAPDVYTDLLTRGAREYHEFDWFREHPPHRPGDEDLVTLRTRRIVLEAALTAAVRREPTVEVRRGCRVRALTLREGRPPRVTGVQVGAEVHQADLVVDVSGRRSPVPAWLIAAGCRPPVVDSHRAGIAYLCRWYRLRADGPRDPGQVKTGSAAPFALGGVFPSDNDTFAVSLVLSTSDPTRGALTDPAVFEAVARHFPATAAWLDLAPEPQSAVLAMAGLDNRWTALSDDDGPVVTGLVNAGDSLIHTNPTFGHGAALGLRAAQYLATHVDQIVADPMGYHRWAAQALRPWFDAQVKADRADEQRLAEGSPSADRRAAALAACAFDDPVVMRARAQVRHLLRLADDAYGTDEVDRHLTAWLAAHPDFTPKHDGPTRDQWDALIPT
>NC_016582|10173037:10232574|10216730_10217933_-|WP_078610730.1|DBSCAN-SWA
MATPLTRPSPPSPKLPTPPRSPPCTRPCADRDRPATPPSTIGKDRTVTSTVTAFAAAAAGEPLTRTTIERRDLGAHDIMVEIHYSGICHSDIHQVHGDWGKGLFPMVPGHEIAGIVTGTGSEVSAHQVGDRVGVGVIINSCGRCDNCADGRQQYCTGGGSVETYGDIDRYRGDEPTQGGYSSHIVVDENFAVRIPEGLSLQEAAPLLCAGITTYSPLKHWNAGPGKKVAVIGLGGLGHVAVKLAHAMGAEVTVLSQSLRKKDDGLKLGADHYYATSDPTTFEELAGTFDLIICTVSAPLDVDAHLNLLTTEGTMVYLGVPDQPISAGVFSLLAGRRSLAGSLIGGIPETQEMLDFCAEHGIGAEVEVVRADQINDAFKRVLNSDVRYRFVIDISTLKPAA
>NC_016582|10173037:10232574|10224512_10225181_+|WP_043487997.1|DBSCAN-SWA
MRSQGGVAPARRRGLADEVADRIREAIFSGAYAPGAQLREVELSGTLDVSRGPVREALRLLEREGLVHCAWHRGTTVTTLSPEDVAELDSLRGALEELAVRQVIAHASDEDLAAVEKTAGLMERATDEHEMVRLDIAFHDAVFAAAGHLRLQDAWEAIRCQVHLFLLTRITHSTEGYITRIPEEHRELVAVLRARDTDTALRLFATHRRLAVDVVAGTTTPK
>NC_016582|10173037:10232574|10184635_10186285_+|WP_055414047.1|transposase|DBSCAN-SWA
MSMRPLPAPAVPESTARVARAAFPRGCLAMRIRDEFGAVFESERFVAAFAHRGGPSVSPGMLALVSVLQYAERLTDRQAADAVRGRIDWKYALGLQLADPGFDFSVLSEFRDRLIAHGLEQQILDAILAQCSERGLLRAGGRARTDSTHVIACIRDLNRLEFVTETMRCALEALAVAAPAWLAGTDAVNTDWLARYRQRADSYRLPKGEAERTAFAENVGGDGYELLDSLDDPTTPAHLADLEAVVLLRTVWAQEYQRDARGVRWRGHKQRPPGAARIVSPHDVDARCGVKRGSAWDGYKTHLTESCDDDLPHLITCTATTPATTDDHQLTAAVHQALTERGLKPAEHYVDGGYTSAKIILQARALGVEVIGPVKQAGGRPALQGSGYAATDFRIDWHTRQATCPQGQVSTRWSDTTIGGEPRIHIDFSRAGCTNCPAKDICTTAAYRVLTLLPREEHELLQQRRAEQQTEEWKKRYHTRAGVEGSISQAVRRTGTRRTRYRGLAKTSLAQVLTAAALNLYRLDAWWTGTPLGTTRISHYEQLALSLAA
>NC_016582|10173037:10232574|10229679_10230591_-|WP_014181187.1|DBSCAN-SWA
MDRMLLMRSFVTVAQLGSFSGAARTLGSSGSLVSRHVAELERQLGVRLVNRTSRSVSLTEPGLRYSEFAARILAEVEAEEAEIAHLHDRAEGLLSVICPKWIGSLDVGDAIAAFAAAYPKIAVRFELGGLSERTYDFLDSGFDVALHTRDLRDSRVRLKKIASLPFTLCASEEYVRQHGPLTRPNDLAAHDCLVHVNEPVWRLGHGPTSTQHKVRNVVFSSNSYIALQKAAVQGRGIALLPQRSAYEDLVSGALRVQLPEVPVPDRPLYAIYGPGQTAPRKIGALLEFLTRWFKEHPIPVLGT
>NC_016582|10173037:10232574|10209346_10210045_+|WP_014181165.1|DBSCAN-SWA
MGNGTASDVSVEVSLERPRKLGDIVLDQVRELIVGKRLPPGERLSEAKIAKMLGVSKTPVREALLQLRMIGLVSMIDGNAHVVVPSARLIREAYEVRAGLEALTARLAAERAAPDRRAQLLPLAEASLQAARDNDAAAFRGLDQEFHHAVALASNNATAQQRIDETLVLCQTLRRRDVLTGWDSQLCGQAHVAIAEAINSGDAEVASREMYGHINYVMDRVLSALAGQQQGA
>NC_016582|10173037:10232574|10218388_10218790_-|WP_014181173.1|DBSCAN-SWA
MTTIDSFSHNVSGEDEFGFAQAIKADDTIYVSGQLSHDEKGDFLHPDDFDAQLKQVYANFEKVLAHYGATRNQVISETQFVVNLPEHNMAMAAANLAYFGAHRPTSSTVGVASLFFPGQLIEISFVLDTRLPA
>NC_016582|10173037:10232574|10223242_10223644_-|WP_014181179.1|DBSCAN-SWA
MATLQSFSFDVPAEQVFGYSQAVKVGETIYVAGQLSHDEDGNFLHADDFEAQAKQTFANLDKVLAHFGATRKQIVQDTVFVVNLSEHVDALAASHVEYFGDHRPATTGLSVDGLVFPGQLFEINVVVDMRLDA
>NC_016582|10173037:10232574|10177329_10178073_+|WP_078610726.1|DBSCAN-SWA
MRTGQVTGNVSPSAHTFSWRSSVRPCRVVIAVAASAAVGVLPFAGTSAAAPARAAAVTVPLREAVASLPVAAEDRTGYDREESFGTWIDADRDGCNTRAEVLLDEALQAPEVTGRCSLVPGTGRWYSWYDDQYVTSARDLDVDHMVPLAEAWDSGASAWPKVRRVAYANDLSDPGHLVAVTKRSNRQKSDRDPVEWMPDQAVHCHYTADWVTAKLRYGLSVDLAEKRKLTELASGCPNAPLTYTPAP
>NC_016582|10173037:10232574|10232445_10232574_-|WP_014181192.1|transposase|DBSCAN-SWA
MGTSKYSSEFRADAVALYRATPGGTYASVAKDLGVNHETLRT
>NC_016582|10173037:10232574|10183401_10184514_+|WP_043492277.1|transposase|DBSCAN-SWA
MGLRLLYLIFCRLLGCLLLLGRSTAASNAEILALRHEVAVLRRQVVRPRLSWADRAVLSALARHLPSVLRRHRLVTPGTLLAWHRRLVRWNWSQTAVGPGRPPLAEEIAALIQRLARENPTWGYVRIQGELRRLGHRVAAATIRRVLRRSGLPPAPQRASQQTWRTFLRVQAHTLLACDFMHVDTVFLKRLYVFFVMETATRRVHVLGVTAHPTGAWVTQLARNLLMDLGDRAGCFRFLIRDRDSKFTAAFDAVLAGNGTAVIPTPPQSPRSNAFAERWIRTARAECTDRLLITGERHLRTALTRYAEHYNAGRAHRSLGLRAPDDDPHIIPLPAAGVRRHQVLGGLLNEYHTMPPRLPHHPQERPSSAA
>NC_016582|10173037:10232574|10192634_10195193_-|WP_055414048.1|DBSCAN-SWA
MRFRPSRPRVAALSLTALLMCAGLPTAQAAPPAQAASSGRSGHIQLEELNRGLVAARTSDGVFLTWRLLADEVTGGSKAGQTGADFHVYRDGKRIATVTDSTDYVDQDASAGASYRVAAVVAGHETNLSDAVTPWDHDYYDLPLKKPAGGVTPAGEQYTYTASDVSVGDTDGDGAYEYVVKWDPSNSKDNSQRGYTGSVLIDTYRLDGTLLNRVDLGPNIRAGAHYTQFLVYDFDGDGRSEMMFKTAPGTKTIRYNSDGSIKSQRYITLPQADRKAGYTSTDDYRLSKDGYYQHLVDLFRNWQNQKEVKSGQWPATLEKCFGIDARYSYPLSEQDAKSLADYFMDVYAPARSTKNALRDFEGFILDGPEYLSVFDGTTGTELQTVHYEPGRTDDGLRWGDYAMARIEPGNRVDRFLSTVAYLDGSHPSAVFARGYYTRTAVAAYTWDGKRLHKQWYADSGWGQMTNPFNDDPHSKDGSNPKYAALTDQGFHSMTSADVDGDGRQEIVYGSATLDDDGSLLYSSYGTLPEGSNAPGKSARLGHGDRIHVTDIDPDRPGLEIYTVHENAKNAPYGVAMRDAATGKVLFGAYSGLDTEQAMVGDIDPDTRGLENWSSMPEGTSQHGLFSATGKQLSTTTPVLSERSIRFTPDMTTQMINNFKKQPELYDFQRGTILKTTGTMGPISLVADLFGDYREEMAVPTTDSSALRIYTNTQDSDHKLFTLMQDPQYRVEVARQQTAYNQASYPGYYFASDTDFAKVPVPSHWTPGGIAALQNQLKGLIDRAAVTGTFFARTLTQDLARAQAHLTRGNRQEAAREVDRFATDLHKQHGGSATQAAASALGYQARTLSVQLR
>NC_016582|10173037:10232574|10198002_10198821_-|WP_078610989.1|DBSCAN-SWA
MLFTVVPFAASLYLAFTDYDLLTPAKWVGLDNFRELFADERLHHSLMVTFVYTFVSVPLSLAVALGVAMLLKSGVKGLPVYRAVFYLPSLLGSSVAVVMLWRAIFGSNGAVNKFLELFGIHGPSWTSDPDTSLSVLIGLHVWTFGAPMVIFLAALKQVPVSYYEAAAIDGAGKWRQFRSVTLPLITPVIFFNLVLSLIGSLQTFTQGYVFSNGSGGPADSTLFYNVYLYQQGFTSFNMGYASAMAWLLLVIVAAFTALNFIAQRYWVFYEND
>NC_016582|10173037:10232574|10211341_10212124_+|WP_014181167.1|DBSCAN-SWA
MDLNLQNKVALVLGAGGGLGGAIADALAAEGAKVALADINKEALDAVQERVGARTATAAVQWDLGDLDSIPGHVAAIGEQLGPVDVLVNVTGGPPPTPVAGQDRMTWSRYFDAMVLSVIGITDAVLPGMRERGWGRVITSTSSGVIAPIPNLGLSNALRSSLVGWSKTLAREVGPYGITSNIVIPGRIATGRITQLDEAKASREGRTAADVSAESVASIPVGRYGTPAEYADMIAFLASPRAGYISGSTIRVDGGLIASV
>NC_016582|10173037:10232574|10186456_10187821_-|WP_043487987.1|DBSCAN-SWA
MPRRSLIWLLSLLCLAAVLAPTAARADNPVVQTIYTADPAPLVHDGRVYLYTGHDEDGSTNFTMKDWRVFSSSDMANWTDHGSPLSVETFSWASANAWAGQVTERNGKFYWYVPVTNAATGRMAIGVAVADSPLGPFQDALGHPLVENGEIDPTVFIDDNGQAYLYWGNPNLWYVTLNEDMTSYSGSPTRIPLTTEGFGSRTGNPDRPTLYEEGPWVYKRNGLYYMVFAAECCSEFIAYSTAPGPTGPWTYRGTIMPREGGSFTNHAGVVDYKGNSYFFYHNGALPGGGGFTRSVAVERFAYNADGTFPTITMSSAGAPQVGTLNPYVRQEAETSAWASGIETQPSSEGGMNVGWIENGDWIKVKGAAFRAGAASFTARVSSQTTGGRIELRLDGADGPQVGTCTVPGTGGWQTWVNVSCPVHGAAGTRNLYLKFAGGSGYLFNVNTWQFSTAP
>NC_016582|10173037:10232574|10204461_10206042_-|WP_078610990.1|DBSCAN-SWA
MACLGVFVAYLPVTTVAVSLPAIQAALDASTAQLSWVQDAFVLPMAAFILTAGVFGDVHGRKKVFQAGLLFSAVGAAVALAAQSIQVLWIGQALAGLGAAALLPTTLALISHAVPDFRERGKFIGLWATSLLVALAVGPLIAGVILDHAAWRWIYLLAIPISLTAMVLAARLLTDSRAPHGRRLDWPGQITATLAITALVYGVIEGGAGSFTDVQVMLALFIAVVSGVAFVLAERRSDSPMLDLTLFRSPAFTATTLIAMITFLALIGFFFLLSLYFGLVQQLDTLQAGWRLLMVTAAAIVAGQPVGRLMHRVSARWLITVGLLVVSGSLFSLTTVDADTSFASIAWRLALLGLGMGGVLTPMTATAVASVPHHLAGMAAAGNNAFRQVGGALGPAVLGALLTARALDTFPGHLADAGVTEATRQSIVETAHTGGLGAVAQMNLGGSTGQALGAVGDAFLDGLRLCLIVAAALALLAALVSVILLRTPRKAATATVTAATNASGHAPSATSAGAVLTAPGEGRTQT
>NC_016582|10173037:10232574|10180169_10181168_+|WP_014181143.1|DBSCAN-SWA
MSIAEGAIYSGGGGGSSFVNGPGVTGGQTLAGNGTQAGGKDDPLHQSPVGDAGNRGQVVLQWTEFTVVPGGPPDVELRQGGAVGYPGVRVEAGVAIDPVSVTVALPPGRGLLFGTQTLADYQLTVQNADGQTTPYMGTLSEDGTSLLFSGVDLGLPGTTVMWVAVSAGHDAPLGSTSLAFTVGGKTSPSTTVVVTPGYTVSPGGAPVTAERGGWPVYPGVEVRNNGSQSIPRQTVTAKLPAGVAMRFGAQDSPDHQLTVWDAGGNTTVYMGSVSDDGQSLTFSDVDLGIPDAGSQSVMWICVSATDDTPPGPTSVEFSVGDRISPSTTINVI
>NC_016582|10173037:10232574|10223707_10224382_-|WP_014181180.1|DBSCAN-SWA
MKVFQIGAAGGVGSRLTRLLTDRGDAVTGMHRNPAQVDTVRATGATPLLGDLIEDSVEELAQKFGGHDAVVFSAGAHGTGREQTTLIDGKGLEKAADAAIRAGVSRFVLVSVFPDALRGGEAGEGFEHYMRVKKTADVYLTRTGLDWVIVRPGTLLDTPGTGRVTAGPAIEYGDVHREDVAAFIDAALHEPALNHVIVELTSGETSVADAVAELVASTTSRRAS
>NC_016582|10173037:10232574|10188199_10189600_-|WP_014181148.1|DBSCAN-SWA
MILHRLRLLLKSSATIAALAMTAALMLGIAPSAHAANADDAYVMAYFKESLSGAGNVNAVHLAVSDDALEWTPLNNSEAILTPTAGTGGIRDPFIHRLNDGTWVVLATDIADSNFWAPNPNIHVWTSPDLVNWSQDRLLAVNRTNPDSFSWAPSIHWDAKRGQYGITFSTVPAGANHSVIMVSYTSDFVTATDPVVFYDAQDYDVIDSTVITGVNGMNYLYVRGNAGLRGTRSASLEPGSFTPYTDNILANGCTEAPTLVKSLTAPTWYLWGDTFCPNNRFDVWQGDLVSGQWTQLGRQDYTPPLNSKHNAIHPITAADRDRLVHVYGSTQWNRLKSFNFPGSYVRHSGFVGRIDELPFEPYEDSQWRLVPGLADPAGVSFESVNHPGQYLRHQNFDVRLSSSDGSAGFKADATFYKEAGLANAHWSSFRSYNYPDRYIRHSGKVLYLHEISGSPGREDATFRVTH
>NC_016582|10173037:10232574|10225319_10226150_-|WP_014181182.1|DBSCAN-SWA
MSKIWFVTGASRGFGRRFVEAALSRGDKVAATARNAGSLTDLVTTHGDAVLPLELDVTDRAAVFASVQQAKEHFGRLDVVVNNAGYGLFGAVEELSEQQLRDQMETNLFGALWVTQAALPFLREQGSGHIVQISSTGGVAAWPLLGGYHASKWALEGLTESLAQEVAGLGIKVTLVEPGGYATDWGGSSAVQADTISAYDGVREGLAAFMETVDFGDPAAAGQALLEVVDSDNPPLRVFFGTQGNEMLPQVYAGRLKTWADWSDLAVRAQGGQAAA
>NC_016582|10173037:10232574|10201793_10202798_+|WP_014181157.1|DBSCAN-SWA
MTTHGTGRRPVTAIAMGEHVAERLITPVIRRRLNALASVRPGHTVTEFDTVDLSDVEVLFTCWHCPPITAQVLDRAPRLRAVIHAAGTVKDHITDACWQRGITVTSAAAANAEPVAEFTLAAILFAGKRVVDIARTYQATRRDHAWDTRYPDLGNYQRTIGIVGASRIGRRVVELLEPFSFNVLVYDPYLAGDLPGARTSDLDELVASSHIVSLHAPDLPETRHMIDATRLAAMRDGATLINTARAALVDQKALTAELLTGRLHAVLDHTAPEVLPPDSPLYGLPNAVVTPHIAGSIGNELARMAHLALDELDRYAHGIPLQHRVDPHALLRTA
>NC_016582|10173037:10232574|10226229_10227075_-|WP_014181183.1|DBSCAN-SWA
MKLGIAMFPADFAIRPDELAVAVEERGFESLFLPEHTHLPATERTRAEVGELPAHFSHTYDLFVALTYAAAATRSLMVGTGIALVAQRDPIVTAKALASLDVLSGGRVLFGVGAGWINEEIANHGTDPARRWSVLTERVKAMREIWEKDIAEFHGDHVRFGPLWSWPKPHRPSGPPVLVGGSGPRAADRVLDFGDEWMPHAGLPVAELADRITKLREAAYEAGRTDEVPVTVFGTAPDAAHLAQLQEIGVNRAVLYAPPTDAETVRRFLDEIAPLVSTFQD
>NC_016582|10173037:10232574|10198948_10200298_-|WP_078610727.1|DBSCAN-SWA
MRHERMRVVGQRSGRRTAIASPGVSRRAVLGLGLAATAAATGCSRFGGLRSGASDGHTVNMVWWGDAIRAQMTEKALDLFRSSTGLEVSTEYQSGTAYDDKLAVRFAGGNPPDLLAVRRETLRDFAGRKALRPLPVGQVIIIEGVPPSVLNAGKIGNVQYGVPFGVASNAWVINTELFAKYKVDVPDLDTWDWDTLKETAAEVTRASGKKVWGATYTMDDILALGVWLRQRGLDLWTPEGRIAFTADSIAEWFQTWVDLRDAGAIPGADDIEELGLAAEQTPVGRKLAASAPIPSNSLAAFNATVHGALKMGFFPGESQADQRGHQLQPVGHWSVSARSKAPDAAFELLDFLINNTKANKELGVGRGAQIKKSVADQVASTLGKDDRIASDYTLRLAEFDLVDPAPDPQGSAELLLALGTISDKVAFGKSSPSKAAAEFFGKARSIIGG

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
10161824:10161840	attL	NA	NA	NA	NA
WP_014181136.1|10173037_10174264_+|integrase	site-specific integrase	B4XYR4	Lactobacillus_phage	3.1e-09	23.3
WP_014181137.1|10174330_10174783_-|tail	lamin tail domain-containing protein	NA	NA	NA	NA
WP_014181138.1|10174932_10175589_-	hypothetical protein	NA	NA	NA	NA
WP_193383758.1|10175585_10176161_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_014181140.1|10176153_10176381_-	hypothetical protein	NA	NA	NA	NA
WP_078610726.1|10177329_10178073_+	HNH endonuclease	NA	NA	NA	NA
WP_106436470.1|10178193_10179450_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_014181143.1|10180169_10181168_+	hypothetical protein	NA	NA	NA	NA
WP_043487981.1|10181906_10183280_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_043492277.1|10183401_10184514_+|transposase	transposase	NA	NA	NA	NA
WP_055414047.1|10184635_10186285_+|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_043487987.1|10186456_10187821_-	family 43 glycosylhydrolase	NA	NA	NA	NA
10186360:10186376	attR	NA	NA	NA	NA
WP_014181148.1|10188199_10189600_-	AbfB domain-containing protein	NA	NA	NA	NA
WP_014181149.1|10189855_10191502_-	glycosyl hydrolase 43 family protein	NA	NA	NA	NA
WP_055414048.1|10192634_10195193_-	rhamnogalacturonan lyase	NA	NA	NA	NA
WP_014181152.1|10195299_10197003_-	acyltransferase	NA	NA	NA	NA
WP_014181153.1|10197070_10197988_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_078610989.1|10198002_10198821_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_078610727.1|10198948_10200298_-	carbohydrate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014181156.1|10200654_10201797_+	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_014181157.1|10201793_10202798_+	hydroxyacid dehydrogenase	NA	NA	NA	NA
WP_078610990.1|10204461_10206042_-	DHA2 family efflux MFS transporter permease subunit	NA	NA	NA	NA
WP_043487991.1|10206368_10207364_+	AsnC family transcriptional regulator	NA	NA	NA	NA
WP_014181165.1|10209346_10210045_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_014181166.1|10210446_10211295_+	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_014181167.1|10211341_10212124_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_043487994.1|10212303_10213716_+	APC family permease	NA	NA	NA	NA
WP_014181169.1|10213824_10215018_+	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_078610730.1|10216730_10217933_-	NAD(P)-dependent alcohol dehydrogenase	A0A2K9L339	Tupanvirus	1.5e-69	42.6
WP_014181172.1|10217844_10218282_-	SRPBCC family protein	NA	NA	NA	NA
WP_014181173.1|10218388_10218790_-	RidA family protein	S4W0G3	Pandoravirus	6.1e-07	30.6
WP_014181174.1|10218817_10219561_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_014181175.1|10219958_10221206_+|transposase	IS110 family transposase	NA	NA	NA	NA
WP_014181176.1|10221251_10222364_-	NADH:flavin oxidoreductase/NADH oxidase	NA	NA	NA	NA
WP_014181179.1|10223242_10223644_-	hypothetical protein	NA	NA	NA	NA
WP_014181180.1|10223707_10224382_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_043487997.1|10224512_10225181_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_014181182.1|10225319_10226150_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_014181183.1|10226229_10227075_-	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_043487999.1|10227234_10228176_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_014181187.1|10229679_10230591_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_014181190.1|10231816_10232128_-	hypothetical protein	NA	NA	NA	NA
WP_014181192.1|10232445_10232574_-|transposase	IS3 family transposase	NA	NA	NA	NA

Sequences of DBSCAN-SWA_5

Nucleotide sequences of DBSCAN-SWA_5

>NC_016582|10315826:10342311|DBSCAN-SWA
GTCACGCTGCATCTCGGTATTCGTGGAGGATGCCGCCGAGGCGATCGTGTCGGCGTATCTCGAGGCGGGCTAACGCGTCGGGATTGTCGATCGGCGGGGGCAATGGGTGCAGTGGCCTGGCGTTCGCGATGCCTTGGTGTGGTCGGTGTCCGTTGTAGAACTGCTCGAACTCGCGCAGGGTGTGGAGGAGGTGTCGCTGGTTCCAGATCAATGTCCGGTCCAGGAGCTCGCGGCGACAGGTCTGTATCCAGCGCTCCGTGATCGAGTTCATTCGTGGCATCTGGATGCCGCTGAGGACGACGTCGATCCCCGCGTCCTTGAGGACGGCATCGAAGAGGGCGGGGAACTTCCCGTCCCGGTCCCGGATCATGAACCGTGCGCGGCGGCCGAGGTCTTCGAGGTCCATGACGAGGTTTTTCGCGGCTTGCGCTACCCAGGATGCGCTCGGATGCGCGGTGGCGCCCAGAACGCGGATCCGGCGACTGCCGTGTTCGATCACCACGAGCACGTACATCCGTACGCCCGACAGCGTGACTGTTTCCATGAAGTCACAGGCCAGCAGGGCATCAGCCTGTGCGCGAAGGAAGGTGGCCCAGGTACTGGAGGTCCGCTCGGGTGCTGGGGCGATGCCGGCCTCCTTCAAGATCTCCCAGACAGTGGACGCGCCCACCTTCACCCCCAGCACAAGCAGCTCGCCGTGCAGACGCCTGTACCCCCAGCTCGGGTTCTCCTTCGCCAGCCGCAGCACCAGGACGCGGATCGAGCGCACCGTGCGCGGCCGTCCCGGGCGCTTGGGCCTGCAGGCGGCGGCATGGCGGCGCGCGACGAGGCTGCGGTGCCAACGCAGCACCGTGTCGGGGCGTACGAGCAGCCGTAACCGTCGCAGGACGTGCAGGGGCATCCGGTGCAGCAGCGCTGCCAGGTACGCCCGATCGCTGGGCGTGAACCGGACCTTGTCCTTGCCGAGTTGGCGTTCCAGCACGGTGATCTGGTGGCGCAGGGCGCGGATCTCAGCGTCCTTGTCCCGGTCGGTCATCGGCAGCAGGCGAAGCATCGCGAACGCGTTCGACACACCCAGGTAAGCCAGTCGCAGCAGCACGATCGATCATCATGACGCGCTGACAGCAGCTGCGCCAGAGCGTCGGACCGAGCGACCGCGGCCAAGATTTCGGGAACCCGAAGAAGCGGTCCCCACCAGGGCGGATGAGAATTCCGGCAAGGGCAGTCGGCGCGTGTCAGTCCCGGTACAGCAGGACCGTGGTGTCAGGCGGCAGCAGGCCGTCCTCGCTCAGCGGGCCCGAGACGAGGAGGGGGCTGGAGCCGGCGGGGAGTGGGATGGGCTGGTCGGAGAGGTTGACCGCGCACAGGACGCCGTTGCCGCGTTCGAAGAGGAGCGTGCCGGCCGGGCTGTCCAGCCAGCAGAAGTCCTCACCCCGCAGGCCGGGGTGGGTGCGGCGCAGGCTCAGGGCGGAGCGGTAGAGCTGGAGCATGGAGGTGGGGTCGGCCTGGTTGGCCTCTGCGGTGTACGTCTTCCAGTCCTCCGGCTGGGGGAGCCAGGGGGTGGCTCCGGTCGTGCTGAAGCCGAAGGGCGGGGTGTCGCCGGTCCAGGGGAGGGGGACTCGGCAGCCGTCGCGGCCTCGGACGGTGTGGCCGGAGCGTTCCCAGGTGGGGTCCTGGAGAAGCTCTTCCGGGATGTCCTCGACCTCGTAGAGACCCAGTTCCTCGCCCTGGTAGATGTAGGCGCCTCCCGGCAGGGCCAGCATCAGCAGGGCCGCCGCTCGGGCGCGGCGGGTGCCGAGGGCGAGGTCGGTGGGGATGGGCTGGTTGCGGAACAGGGCCTGTACGCCGGTGTCGGCGCGGCCGTAACGGGTGACGTGGCGGGTCTCGTCGTGGTTGGACAGCACCCAGGTGGCGGGGGCGCCGACGGTGGCGAGGCTGGTGATGCTGCGGTCGATGACCTCGCGCAGCTTGCCTGCTTCCAGGGGGCACTTGAGGAAGTCGAAGTTGAAGGCGGTGTGGAGTTCGTCGGGGCGCAGGTAGTCGGGCATGCGGCCGGGGCGGACGTGGGCCTCGGCGACGAAGACGCGCGGGTTGGGGTAGCTGTCGGCGATGGCCCGCCAGCTGCGGAAGATGTCGTGGAGGCCGTCGCGGTCCCAGTGCGGGTGGTCCTGCTGGCCCTCCCCCGTCAGGACCGAGAACTCGGTCAGGCCCAGGTCGGGCAGCGCCGGGTCCTTGACCATGCCGTGGGCCACGTCGATGCGGAAGCCGTCGACGCCGAGGTCGAACCAGAAGCGCAGGATCGACTCGAACTCGGCCCGGACCTCGGGGTTGTCCCAGTTCAGGTCGGGCTGTTCGGGCGCGAAGAGGTGGAGGTACCACTGGCCGTCGTCGGTACGGGTCCAGGTACGGCCGCCGAAGGCCGCGTGCCAGTCGTTGGGGGGCTCGCTTCCGTCCTCGCCCTTGCCGTTGCGGAAGACGAAGCGGTCCCGCTCCGGGGAGCCGGGGCCGGCGGCCAGCGCCTGCTGGAACCAGGCGTGCTGGTCGGAGGTGTGGTTGGGGACGATGTCCAGGATCACGCGCAGGCCGAGCTCGTGGGCCTCGGTGATCAGCTGCTTGGCCTCGTCGAGGGTGCCGTATGTGGAGTGGATGTCCCGGTAGTCGGAGACGTCGTAGCCGCCGTCGGTCAGCGGGGACGGGTACCAGGGGTTGATCCAGATCGCGTCGACGCCGAGGTGGGCCAGGTACGGGAGGCGGGAGCGGAGGCCGGCGATGTCGCCGGTTCCGTCGCCGTCGCCGTCGGCGAAGCTGCGTATGTAGACCTGGTAGATGACGGCGGAGCGCCACCAGGAGTCGTCGACGGGCAGCGAGGTGGGGGCCGGGTTGCTCATGGTGCTCGATCCTGACTGTCTGGAAGAACGGTGGGGGTGGTGGTCAGCCCTTGACCGAGCCCTGGAGCAGCGCCTTGACGAAGTGGCGTTGCAGGAACAGGAACACGAGGATCGTTGGGGCCATGATGAGGAGGGCGCCGGCGTTCAGCAGGACCTGGTCGGTGCTGTATTTCGTGGTGAACGCCTGCAACGCACCCGCCATCGTTCGCTTGTCGGGGTCGTCGATGAGCACCAGGGCCAGCAGGAACTGGTTCCAGGTGGACAGGAACATCAGCAGGGCCAGGGAGGCGATCGCCGGGCGGGCCAGCGGCAGGTGGATGTGGAACAGGGCGCGCCAGGGGCCCGCGCCGTCGATGCCCGCCGCCTCGGACAACTCCTTCGGTACGCCGATGAAATGGGCTCGCATCCAGAACACGGCGAACGGCATGTTCATCCCGATGAGCGGGAGGATCAGCGCCCATTGGGTGCCCAGCAGGCCCATGGCCTTGGTCTGTTCGTAGAGCGGGACGATCACGATCTCGTACGGGAGGGTGAGGGTCAGGACGAGGATCGTGTAGAAGACGCGGCCCAGCGGGATCTCCAGTACGGCGATCGCGTACGCGGCCATCGTGGCGATCAGGACCGCCACCGGGACCACGCCGAGCACGATGAGCGTGCTGGACTTCAGCAGGGTCGTGATGTTGGCGATGCTCCAGGCGTCGACGAAGTTGTGCCAGTGCGGGTCGGATGGCCAGCTCAGGCCGGAGGGGAAGGTTCCCTGCGGGGCGAGGGCCGCGCTGACCATGCTCAGCAGCGGGACGACCGAGTAGAGCCCGGCGGCGGCGATCAGGACCAGCCCGGGAGCGCGGCGGCGCAGTGTCCGTACGGTCTGCGTTCGTTCGGGCATGGTCACTTCTCCCGGAACAGGCGCTGGAGCGGGGCGACGACCGCGATGACGATCAGGGCGAGGACGACGGCGAGCGCGGAGGCCGCGCCGAGGCGGCTGTCGCTGAAGGCCAGGTTGTAGACGGCGACGCCGGGGACCATGGTCTGGGTGCCGGGTCCGCCCTGGGTGGCGAGGTAGACGACGTCGAAGCTGGCGAGGGCGGCGATGATCGTGATGGTGACGCAGACGCCGATCTCGTTGCGGAGCCCCGGCAGGGTGACGGCCAGGAACTGGCGGATGGGCCCGGCCCCGTCGATACGGGCCGCCTCGTACAGGCTGTTGTCGATCTTTCCGATGCCGGCCAGCAGCAGCATCGTGCACAGCCCTGTGGACAGCCAGGTGCCGATGAAGCCGACGGCGGTCAGGGCCCAGTCGAAGTCGGCGAGCCAGGCGCGGGCGAGGCTGCCCAGGCCGACGGCGCGCAGGGTCTGGTTGACCACGCCGTTCGCCGAGTACATCCACGTCCAGGCCACGCCCGCGGCGGCGCCGGGGATGATCTGTGGCAGGAAGAGGAGCGTGCGGGCCAGAGCTCCGGTGAAACGGCCCTGCAGCTGCCGCAGTACGGAGGCGGTGATCAGGGCGAGGGTCACCGGCAGGACGGTGAAGAAGAGGATCAGGTAGAAGGCGTGGAGAAGGGAGGAGAACTGCTCGGAGTCGGTGAAGACCTCCGTGTAGTTCTTCAGGCCCACCCAGGTGGAGGCGCCGATGCCGTCCCAGTCGTAGAAGGAGTACTGGATCGACAGCAGCACCGGGTAGAAGTTGAAGATGCCGTAGAAGGCGAGGGCGGGGAGGGCGAACAGCCAGCCGGCCCACCGCCGGGCCCAGAGCCTGCGGCGGCCCCGGGCGGCGGTGCCCTCCCTGGTCGGTCGGGTCGAAGGCATGGTGCTCAGTTGTCCTTGACGGCGTCGGCGTAGGTGGCCTGGAGGGTCTTGACCATCGCGGCGGGTTCGACCTTGCCGGAGACCAGGAGCTGGAGCTGCTGGGGCAGCTTGGTGTTGACGGCCGGGGCTGCGTTCTGGATCCAGCTGTCGAAGCCGTTGTCGGCGGCGATGGCGGCGTAGCCGGTCTGGATCTGCTCGGTCAGGGTGCCGGACAGGGACGGCGTCTTCCCGGAGTCCGAGGTCACCGCGGCGTAGCCGTTGTCGACGGCGACCTTCGCGGCCTCGGGTGTGGTGAGGAAGTTCAGGAACAGGGCGGCGGCGTCCTTGTGCTTGGAGTGCGCGGCGATCGAGTAGGCGAGCGTGTTGCTGGTCATGCCCGCGTACTTGCCGCCCTTCTCGGCGGGCGGCATCGGGAAGACGCCGTACTTGCCCTTGAAGGTCTTGTCGATGGTCTGCGTGATCCAGCTGCCCTGGAAGAAGAACAGGCCCTTGCCGCCGGTGAACTGGCCGTACGACGCCTCCTGGTTGATGGCGTTGACGTCGGACGCGAAGTAACCCTTCTTGATCCACTTCTGGAGGGTCTTGGTGGCCTTGAGGGCCTCCGGGGTGTCCAGGGTGGCGCCCGGCTTGTGGTACACGATGTCGCTGAGCTTCTGGGCGCCCATGTAGTCGCCGAGCAGCAGGTTGTAGAGGTGGCCGATCAGGCCGTCCTGGTTGGAGGCGACGATCGGGGTGATGCCGGACTTCTTCGCCTTGGCCATGACGGCGTCGAGCTCGGCGATGGAGGCGGGCACGGTCTTCATACCGACCTTGGCGGCCAGCTCCTTGTTGTAGAAGACGCCGGTGAGGGGGCCGGCCGAGCCGCCCGCGAGGTAGAGGGCGCCTGAGCCGATCACGCCCTTGGACACCCGGCCGGGGGCGAGTGCGGAGGCGGGGACCTTCTTGCTCCAGCCGTACGCCTTGTCGTAGGCGTCGAGGTTGGTGAGCAGGCCGTCCTTCACCCCGCCGAGGAGGTCGTTGGGCGCGGCGATGTCGGGCGCGGAGTCGGAGGCGAGCAGCCTCGGCAGCACGGTGTTGTAGTTGTTGTCCGCCTCCACCCGCAGCTTGAGCTTGAGCTTCGGGTACTTGGCCATGAAGGCGTCGGCCAGGCCCTGCTCGTACTTCTCCAGACCGGCCCCGGAGAACAGGGTCAGGGTCGCAGGGGTGCCGCCGACGGCCGTGTTCACGGCGGTCGGGGTCGCGTCGGCCGACGAGCCGGAGCCCGAGCCGGGCCCACTGCACGCGGCGAGCGTGGCCAGTGCAGACGCGGCGGCGACGGCCGCCAGCGGGGCGCGCAGGCGGCGGCCGACGATTCTGGCGGGGGAGGTGGGGTGCTGCTGCTTGGGCATGATGCCTCCTCGCATCCATGCGTCTGCCGCTCCGCTCAAGGTCGGCAGACAGAGGTCGGCGTGCTTCCCGGAACGGCCCGCAGAAGAGCGCGAAGGTCGTTTCGGAAGCGTTTCCGTTGCCGAAAGACTGAGGTGACCGACCGCATCTGTCAAGTAACGAAAACGCAACATGCACGTGACGTGCCGAAATGATCAGAGGGCCGCGCGGACCAGCAACCCAGGTCGATGAATCCCCTTGGAAGCACTTCCGGGAATCTCGGAAGCGTTTCCGGGACCTTCCGTATGTGGGTTAGCCTTCCGGCATGGCGCAGAGCTCCCAGAAGATCAACATGGCGGACGTGGCCCGCGCGGCCGGCGTCTCGATGGCCACCGCCTCACGCGCGCTGAACAACGAGAACGGCGTCGCCGAGGCCACCCGCCGTCGTGTCCTCGCGGTCGCCGAGGAGCTCTCCTACGTCGTCTCCCCCGAGGCGTCCCGCCTGGCCGGCGGCGACACGGGTCGTGTCGCGGTGGTCGTGCCGCACATCTCCCGCTGGTTCTTCGCGGCCCTACTGGAGGGGCTGGAGTCAGTGCTGCGCGCCGCCGACCTCGACGTGCTGCTCTACCATGTCGACGGCATCGAGGACCGCCACGACTTCTTCCACCGCCTGCCGGCCCGCCGCAAGGTCGACGCGGTCGTCGTCCTGGCCTTCCCGGTCGGCGAGGAGGAGCAGCGGCGCCTGGGGCTGATGGGTGTCACGATCATCGCCGCGGGCGGTCAGCACGCGCCGTATCCGAACGTGTCCATCAACGACGAGACCGCCGGCCGCCAGGCCATGGACCACCTGCTCTTCCTCGGCCACCGCCGCATCGCGATGATCGCGGCAGTCGATCCCGACCAGCCGGACGAGGTGCAGCCGTCGGGCCGCTCCAACGCGTATTACGCCGCCCTGCGCGACGCGGGCATCCCCCTCGACGAACGCCTCGTCGTCACCGTCGACTGGGGCGGCGACCAGGGCGCCGACGCCATGGCCAAACTCCTCAGTCGGCCCGAACCGCCCACCGCCGTCTACGCCCACTCCGACGAGGTCGCCCTCGGCGCGATCCGTACCCTGCGCCGGGCGGGCCTGCGAATCCCGGAGGACCTGTCCGTGATCGGCATCGACGACCATCCCGTCGCCGAGCTGACCGACCTGACGACCGTGCGGCAGCCGGTGCGGGAGCAGGGGGAGCTGGCCGGGCGGATGCTGCTGAGCATCTTGCGCGGCGAGGAGACCGAACACGACGTCGTCGTACCGACGCAGCTCGTGATCCGGGGGAGCACCGCGCCGCCCCGCTCGTGAGGCCACAGCTGGTCAGAAGTGGGTGGCAATACCGAACGCCTGCCGGAGCCGGGCCATGTCGTGACGATCGCGGTCGGTCGGCTCGTACCCCTGATGGAAGTAGACCTGCTGCTCCGGCGACAGACACGGGACAGCGGTGCCCCGGATCGTGCCAGTGACGAAGCAGGAGACGGGATAGACAAACGGCCGCCCTGGGTCGGGCGACGCCTGCACCGCGGATCCATCCGCGGCAAAGGTCAACGGGTGAAGATCGACCTCTCGTCCGGACGGATCGGCGACGACGAACCGCACGGGCCGCCCGTCGAGGGTCTCGACGTATCCGGCCTCTTCGAGAGCCGCCAGGACGGCCGGTTCTTGATCCTCACGGTGCATCAGGTCCAGGTCACGATGCGGTCGGGTCTGGTCACCGAGCAGGGCGTCGATGCCCCAGCCACCACCGATCCAGACGTCGGCGTCGGTATTCCGCAACACGGCGAGGATGGACAGTACGTCGTCAGCCGTCATCACCCCGCGCACGCTAGCGTCGATCATCCGGGCGGGCGAATGGATTTACTGGCGAGCAAGAGCCCCATCCCTCCGAACCCGCAGGCAAGGACGGCACATGCAGCAGCAACGCGTGATCCCCCAGCACGAAGCCACCTGGCTCAACCAACCCTGTGGGGGCCGTAAACCGTGCCAGGACCTCCATGTCCTTGTCCCGCTCCCTCATCGATAGCAGCCGCAGCATCGCGAACACGTTTGACACGCCCAGGTACGCCAGTCTCAGCAGCACGAACCACCATGATGCCCGGTTGATCGTCAACCCTGCCGGAGCGCCGACTCAGAACCGCGCCCGACATCCCGGAGATCACCGCACATCGGCTCCCACCAGGGCGGATGAGGTTATCGGCTAGGGCAGGACCACCAGTCGTATCCTGCGCAGCACGTCCCGTGGCAGCCGATGCAGCAGCGCCGCCAGGAACGCCCGGTCGCTCGGCGTGAACCGCACCCTGTCCTCGCCGAGTTGCCGCTCCAGCATCATGAACTGGTGGCGCAGGGCGAAGACCTTTGCATCCTTGTCGCTGTCGCTCATCGGCAGCAGGCGAAGCAGGGCGAACGTGAGTTACGGCCAGGTAGTCCAGTCGCAGCAGCACAACCGACCATCATTCCGTAGCGCTCGATACCCGCGCGAGCGAGCAGGCTCAAGCGATCGCCGTGGAAGCCCGAACAGCCCGCTCACCGCTTCCCATCAGGACGGATGGGGTTTTCGGCAAGCGCAGGGCCTGAACCAAATAGCGGCGGCCACCGCCCCGGGGGAGGTGGGGACGGTGGCCGCACTTGTGCTATCGGCGGTCAACCGAGCGTGACGTCAGTCGACGTTCACCCAGTACGGGTCCTCTACGGGCCAGGCCAGGATCCGGTCGTCGACATAGAAGTTGCTGAGATTGGTGCCCGCCGACCGGTTCTCGCCCTTCTCGATGTTGCGCACCGAAAAGTCCCATTCGATCGACGATGCGCCCTCATAGGTGGAGCTGAAGGGGTACTCGTCGCAGTCATCGACCGAGGTGTTGTACGGCGGAAGGCCGGTCGCGGCGTTGTAGTCCGGGCCCCACGGGTTGGACCCGCCCTTCTGCCCGCATGCCGCCTTCTTCACCTCCTCGTTCGCCAGGGCGATCGCGCCGCCCTGCCCCCGGCTTACCACGCGGTGCAGCGGCGCGCCCCGAGCCCCGGCGGTCGGCGACCACTTGCCGGGGACCTTCTTGGGGTGGTTCTCCTTGGGGTAGGTGACGCCGTCGGTGGCCGGGGCGTTCTGCGCGTCGCGGATGTGCTGGCGAATGTTGGGGTGGTTGCCGTCGTAGGTGAGGAAGGGCAGCGCCCCGGTGTAGATGCAGGCGTGCGGGTAGCGCTTGACGCCGTGGGTGAAGTAGTCGGCCGAGTCGCAGCGGATACCGATCGGGGGGCCCTCACCGCGCTCGGTGCTCTGCTCGTATCCCGGGCTCGCGCCGTTCATGTAGAGGCGCCACTGGTGGAAGGCGACCTGGTCCTGGCCCTCGCCACCGATGGAGGAGACGTCCCAGTAGACCCAGTCAGGGAAGTTGCTCCACTGGGCCCATTCCATCTTCGCCGGAGACCGCCCGACGCCGCACGTGGCAGTGGTGGGCTGATTGGCGCCCGGCACGCATTCGGGGGTGATTTCCAGCTTCAGGTTCGGGGCGACGGTCCGCTTCTCCAAGGGGTTCCACCCGTCGTAGTTGACCTGGCCGGTTTTGGCGCGGAAGAAGACGCGGGTAGCGCGGGTGTCGTTGTAGCCGATGGCGGCGGCCTGGAACTTGATCGTGTTGGTGCCCTTCAGGACGGGCTTGCCGTCCACCTTCTTGTAGTACCTGTTCTTGAATTCGTATTCCTGGCACCACTTGAACCGGTTGTAGACGCGGCCGTCGGGGTCTTGGGCGTCCGAGGAACCGAGACAGTCGTTCAGCCACTCGGTGCCCGCGGGGTTGTCGGGGGATATCGGCATCTCCGCCGTCCCCTTGCCGTTGCTGCTGCGCTGAGCACCGTCGCCGGGCTTGGCCGTGTACTCGATGCCCGGGGCCGACGCGGGGGGCTTGGGGCTTGCGGCGGCGGCCGGTGAGGCGCCCAGGGCGAGAAGGGCTGCGGTGAGGGCGAGTGCGGCTATAGCCGCCAGCAGTCGACTGGCGCGTTTCAAAGGTGGTCCCCCCTTTTTTCCGGTGGTATGTAAATCCACTCGGGATCGAACCGGCGTAGTGCCCGTCTGCGTCAGCCAGAAATGGGTCTTCCATGATCGTTCTTTGGCCCGTTCGGGCCTCACACCGCCGCCCGTCTTCGCGACGGCATTCCCGCGGTCGGCAGGATGCGCGGGCACGGCGGCCGTCGCTGGGCCGCCGAATGCGACAGCGGCTGCCGGCGTCGCCCTTGACAGGGCACGGCGCCGCCTGTTCGGTCTTCGGTCCCGTCCTCCGTGGTGACGATGTAAACCTGGTAAGGACATGTTCGTTTTCTCCTTGTTTTCCGATTGGTTGTGTTCCGTGCCCGTGCTGGATGCGGTCGGGGATCATGCGGACACTGCCGGATCGGCTGTCGGGATCGAAGCTCCTCCTTCCGGCTCACCGCCAGCCACCGTCTGGCTTGTTTCGCTGGATTCTCTTCTGTCATGCCGACGATCGTCTGCCCCCCATGGTTCATAGGGCCGTTCCCTCTGGCGCGCAAACATTCAAGGCGCCACGGCCGCCGAAGGCCCTCGGTTTCAGAATGCGCAAGATGGCCGAATACTGTGATGGCTTGGTGGCGGTCGGCCGCGCAGACAGACGATGAAATCCGTTCTGGCAGTCGCTGGCCGTCGAGGTGACGGCAGCGGAATCACGACTGAAACAGCCCATCTGTGCGACGGCGGTGGCAGATTGTAGCTCCGCAGATGAAATCCTGATGAACCCCGGGCAGGTCAAGACTGCCCAACAGCCGGTGAAAGGCGATGAGTTCCGCCTCGGACCGGCCGATTCCGTCATCGCCACTGCATCGCTGCCGACGCTAAATTCGCCTCAATCGACCACCGCTCCCCACCACATAACTGGCAGGGTTCCGGCCCGGGGCGTCATGGCGCCCGGCCAAAGAAAGGGCATGATGAGCCACTTAAGATCTTCCGGCCGCTGGGCCAGAGGGCTGATCGCCCTCACCACAACCGCTGCATCGACGCTCGCCGCCATAATTGCCGTGGTCGGCCCCGCCGCCGCCCAGGGCGCCACCCCCGCCGCCGACGCCAGCGCCGTTCAGGCCGGGCAGTCCTGCACGGCGGCCGACCTGGGCAAGCGCCACCCGTTCATCAAGTCAACCGAAGTCGCCCCGACGATCACCCACTTCAAGGGCTGGTACGTCACCGCGGGCTCGACCGGCTACCAGAACGTCACCACCAGCACCCAGACCACCATCTCGGTCTCCGTCGGCCTCAACGGCGAGATCAAGGGCGATTTCGCCGTCGAAGCCCTCGGCACCGTCGGCGCGATGCTGGGCCTGAACGTACAGGTGAACTACTCCTCCACCAGCAGCGAGTCGACCTCGGTCAGCTGGAACTTCAACGACCCCGGCTACTACGGCGTCTACAAGGGCACCAAGAAGGTCACCGGCACCTACGGAAGCCTCAACTGCAACCGCGTCCAACAGGGCGACGGCAGCTGGGCGCTGAAGTGGATCGAGGGACCCGACAGCGGCAGCTACACCACCTACACCACCCTCGAAGAGGGCGCGGTGCGCTGCGAGGACAAGGTGCCCGCCAACAGCATCATGCGCAAGGCGCAGGGTCTCCTGGACTGCGAGACCCCGCCCCGGGCCGGACACGCACCAGGGCCGGTGGCCTCCGCCAAGGCCACCGCGGCCAGGAACGCGGCAGCGAAGGACACGGCGAAGGGCACAGCGGGCAAGGCGGCCACCGCGCGGACCAGTGCGCCCGCCACGCGGGCCGCCCTGAACTGCCAGCCTGACGTCTACAGGATCCACGTCCCCGGCAAGCCCCTGAACTGGAGCGCACCGGTCCTGGCCAACGATGGCATCCGGCTGCGCGAATCCAACTGGACCAGCGCCCACCTGGACAACTGGCGGCTGTGCAACGTGACGGAGCGCAACGGGGTTATCGAGGCGTCCCTGTGGAACTGGGGCAATGGCGGGTGCGCGACCATCCCGGCCAACATCGCCAACCAGGAGCAGGCCTACCTCACAACGGCCCCTTGCGGGGAGGACGACCTCCAGCGGTTCTACATCTATCGCGACGTACCTGGCGGCTCGAAGATCGGCCTGCAGAACAAGTACACCGGTTCCATGCTGGGCCACGACCGGTACGCGGACGGGGAGTTGATCCGCCAGTACTCCAGCGGCAGGCAGGACGGTACGGGTACGTACGACCTGGTGAAGGTCTGACCCTTCCCCCGTACCGCTTCAGAATTGCTGCACGCTCTCTGACCTGGGGCGATGCCTGCAGGGCCGATCCGGCACCATCGGAGCTTGTGCTTGTACGAATGGTCTACCTGATCGCCACGCGGATCTTCACGTGGCTGGTTCTGCTGTCCCGAACCTCCGTGGCCAAGGAGGCCGAGATACTGATCTTGCGGCACGAGGTCGCGGTCCTGCGTCGGCAGGTCGCCGCGCCCAAGCCCTCATGGCCCGGCCGGGCGCTGCTCGCCGCCCTGGCCCGGCTCCTGCCGCGGGCGTTGCGCCAGCATCGCATCGTCTCCCCGCGCACCCTCCTGGCCTGGCACCAGCGTCTGATCAAGGACAAGTGGAGGCAACCCGCCTCGCCGGGACGCCCGCCTATGCCCGAGGAGCTGCGCGACCTGATCATCCGGTTCGGCGCCGAGAACCCACGATGGGGCTTCCGGCGAGTCCACGGCGAACTCCGTCGCCTGGGACACAGCGTCAGTCAGGCCAGCGTCCGCCGGACCCTGCGTGCCGCTGGCCTCGGCCCAGCCCCGCGGCGGCATCCGGTGCGCGGCGAATGGGCCGCCTTCATCAAGACCCAGGCCCATGGCCTGCTTGCTACCGATCTCTTCCACGTCGACACCATCAGCCTGCGGCGGCTGTACGTTCTGTTCGTTATGGAGGTACGCACCCGCACGGTGCATATCCTGGGTGTCACCGCCCACCCCACCGCCGTCTGGGCCACGCAGCAGGCCCGACAGCTCATATGGCAACTCGGCCAGCGTGCTGGCGACTTCACCCACCTGATCCGTGACCGGGACGCGAAATTCACCGCAGCTTTCGACGCCGTCTTCGCCAGCGAGGACATCACCGTGACCAAGATCCCTCCGCGGAGCCCCAACTGCAACCCGCACGCCGAGCGGTTCGTGCGCTCGGTCCGCGAAGAATGCACCGACCGGCTCCTGATCTTTGATCGGGGCCATGCCGAGAAGATCCTCCACGACTACGCGAGGCACTTCAATGCTCATCGGCCGCACCAGGGCCGGAACCAGCTCGCGCCCCTCGACGACCCCAATGTCATCTCGCTGCCCGCAGCTCGGATCCAGCGCCGACAAGCCGTCGCGGGCCTCATCAATCAGTACCACCGAGCAGGCTGATCACCCGGCAAAGCGACAGCTCACGGGCTGTGCAGAGAATCTGAATCGATACGGGTGCAGCAGGCGCGGAGTCTCACCGCCGGCCTGGGCATACGCATCGAGTCCCTGTGCTTCTTGCTGCGCGAACGCGAACGCGACGGTAAGTACGGCGAGGTCTTCGACGCCGTCTTTCGGGCCGAGGAGGTGCAGATCCTCTAAAGTGCGCCACAGGCTCCCCGGATGAACGCGCACTGCGCACGCATCATCGGCAGTATCCGAGGCGAAGCCCTCGACCACGTCCTCATCATGAACGAGGCCCACCCCCGCCACGTCCTCGCGGCCTACGAGCGGCACTACAACGAACACCGCCCTCACCAGGCTCGCAACCAGCTACCACCCGATGCTCACAAACAACCCGCCGCAGCGCATGCGCTCAGCACCGGCAAAGTCCTGCGCACGCGGATCCTCGGCGGCCTCATCAACGAGTACAAATATGCGGCATGACATGCAGCGATGACTTTTCGAGCGGCACGGGGGCCCGGCGGAGGCCTTTGACCAGGGCGGATGGCATTCTCGGCAAGCGCACCCGGTCGCGAACCATGAAGCGCAGCGGTCGATGTGCAGGAAGTCGCGGGCGATGATGGAGTCTGCCTGCGCGGTGAGGAACTCTCGCCGCGTCGGCGCGCCTCTGCGGGGAGTTGGCTGTGGCGCCGACTCGCGGGTCTGATCTCAGGAGACGGCGTTGCTCAGGTCTTGGATGCGGGCTTGGATCAGGGGAAGGATCTCGGTGGTGGCTCGTTCGACGGAGGTGGCGAGTACTTCGGCGTTGAGCTTGCGGTGTGGTACGTGGGCGAGTTTGTCGCGCAGTGCGATGGGGCCGCTGTATGCCTGTGTCACGATGCCGTGAGATGCCTGTTTGAGCATTTCGCCGAAGGTGAGCATGCAGTAGGCCAAGGCGAGGAGGCGCTCGTTTCCTGGCTTGGGTGTTCCGTCACGAACGAGGGAGCGGGCTTGGTCGAGTGCTGTCGTTGCGTCGGTCAGGCGGAGCAGCTCCCGGTGTTCACGGTCGGTGCGTGTGTTGGTCATGCCGCCCCGCGGAGGTCGTTCAGGGGTTCGGTTTCTTCGACTTCCACTCCGGGGCCGCGTGGGACGACTTCCACGAGGGCGCCGAGGATGCTGGACAGGTCTTTTTCGAAGCTGGTGATGTCGAAGTAGGAGCGGTTGGGGTCCAGGGTGGCGACGAGTTCCCCGGGCTCGGTGCTCAGGGCGAAGGAGTGCAGGCCATGGCGGCGTCCGAGCTGGTGGATGGTCGTGGCGTTGGCGCGGAGCTTTGCGGTGGTGGCTGGCCTCACAGCTCCTCCTCCTTTGCGATTTCGGGCACCGGAATCGACAGGAGCCAGAATATAGGAGTGAGGTAGCAGGATGAGCGTGCTCGGGAGCGGGCTGCTGGGAGCGGCATTCTCTTCCTCCGTCTGGCGCTCTACGGCTCCGAGAAAGGCCGCTACTGTGTGCAAGCTGCTGGACAAGGGGTCCGTACTGCTCCCCGCACCCGCGGGGATGGTCCCGCTCAGGCCGCGCCCCAGAAGCGCGGCCTCACCTGCTCCCCGCGCCCGCGGGGATGGTCCCGAGTCCGGCTTGTACTCGATGCACCCGTCGGGATGGCCCTGCGGCCGACACGACACCTGCAACCGGGAGACCTGCTCCCACGCGTGGGGATGGCTTGAGGCCGGTGAGCGTGGTCGCGTGTGCGTACGGTTGTCTCGACGCCTGCAGAGAAGATCTCGAATTGCGGCTGATGCCAGAGGAGAGATGTAAAGGCCCCTGTGGTATGTGGGCCGACATTCGTAGTTGGGCCTGGGACGGCTTCGCTTTCGTGGTCGAGAGGCGGGGTGGTTTGGTTGCTGGCCGAGACGAGAAACGCGACGACCAGTCAAGGGCGCATTTGGCTTCTGGCCGTGGTGGCCTGGGGGCCCTCGACCGATCGCCTCGTTTTTCGTCTCGGCCAGCAACCAAACCACCCCTCTCGCGCATACGATGTTCCGGAAAGCGGCAAGGGTAGGGCTTGGAAAGGTTACTCGCTGGTGGCGTGATTCTCAGACGTTATAGCGGGCTGACCCTGTACCGGGCAGAGAGGCCAGGCGTAGAGTGGATACATGCGATGCTCGGTCAGGATCTCGGCTCTCAGCCAATCAGGAGCGCGGAGGTCAGTAGACGCGGACTCCTTTACTCGGCTGATTTCGCTTGACCGTGACCTCGATGAATGGACTGGAGCACGCCGCTCAGACGCATTTGAGCTGGGGGTCAAGGGGTCGCAGGTTCAAATCCTGTCGTCCCGACCAGCATCATCGCAGGTCGGAGGCCGTTTCCGCGGGTAGCGGAGGCGGCCTTAACCATGTCCGGGCTGGGAGCAAGTGGGAGCCCTCTGGGGGCCCTCGTGCTCCCAACTCGCAGACGTGTCAACCATGTCCGATTCGTCCGTCACCCGATCCGGTAGACCTACAGCGCAGTACCGAGCCCCTGTGCGCCGTCGTCAACCACAGACCCCCGACGTCACCCGATCGATTCGGATGCTCTCTGCATCGAGAGGCATAAGGACCCCTTGTCGGCTCTCGACCCCCTTTCGGGGTGGGAGCACGATCTCGTGCTCCCCATGCGACAGGGGGGAAGCTGCGGGCTGAGGGCCTCGGTCGTCGTGTTTCCGCAGGTAGATGGTGCTCGGATGTCCCGGCTGCAAGGTACCTGCCGCGTCAAGACGAGGTAATGCCCCTTGGCGTCCGCCGGCAGACGGGGCACTCCCAGGGCGTGAGAGCCCTATCGGGCTCTGGGGCGCCGTAGCGAGACAGTCGGCAGGTGCCCTTGCGTGCTAAATAGTGTGCCAAGTGCTGCTGGACTGTGCGGGTGCCGATAAATCATCCGCGCAGCTCAGGCGGCTCTACCTTCTTGATCGGGTTGACCGAGCCATTCGTAGGGTTGGGTCGCCCAGGGGCGCTGGGTGTGGCTATCAGGCGGCTGCCGATCCATGGCTGAGCAAGCTTTGCCGCCCGGCGCCCCACGACGACTCGGCCGCCGATTAGGAAGTGCGAACAAGTCGCTGTGTAGAGCAATGCCGGCGAGGTCGTCCGTGGCACGAACAGCACGAACCAGCACGTCAGGAGCACGATGAGCCGGATATGGGCGGGGATCGACAGTGGCAAGGGCCACCATCACGGCCTCGCACTGGACACAGACGGAAAGACCCTGCTGTCGCGACGGGTCGCCAACGACGAACCCGAGCTGCTGAAACTCATCGGGGACGTCCTCGACCTGGCCGACGGTCGTCAGGTCACCTGGGCCATCGACATGACGGGCGGGGAACCTGCGCTGCTGCTGGCCCTGCTGGTCAACCACGGCCAGGAGGTCCTCTACATCCCCGGCCGCCTGGTGAACCGGGCGTCCGACGGTTACCGCGGTGAGGGCAAGACCGACGCCCGCGACGCCTACGTCATCGCCGACCAGGCCAGGATGCGCCGCGACCTGCGGCCCATCCGCCCCGGCGATGAAGCGGTCATCGAGCTCAGGCTGCTGACCGGACGCCGCGCCGACCTGGTCGAGGACCGCACCCGCGTGGTCAACCGCCTGCGCGGCACCCTGCTGAGCATGTTCCCCGCTCTGGAGCGGGCCCTGGACGTCACCAACACCGGGCCTCTCAGGCTGCTGACGGGCCACCAGACCCCGGCCGCGATCCGCCGGGCCGGCGTCATACGGCTGACGAAGTGGCTGGCCAACCGCAAGGTCCGCAACGCCCGAGCCCTGGCCGAAGCGGCCGTCGAGGCGGCCGAGCGGCAGCACACCGCGATCCCCGGGGAGAAGACCATCGCGAAGCTGGTCCACACCCTGGCCGAGGAGGTGATGGCCCTCAACGAGCAGATCTCCGAGGTGGACAAGCTCATCGAGGGCGGGTTTCACGAGCACGAGCTCGCCGAGATCGTCCTGAGCGTCCCGGGCATCGGCACCGTGCTCGGCGCGGAGTTCCTGGCCGCTGTCGGCGGCGGCCTGGACGAGTTCGACTCCCCGGACGCGCTGGCGGCCTTCGCCGGCGTCGCCCCGGCGCCCCGCGACTCGGGCAAGGTCAGCGGCAACCTCCACCGGCCGGTCACCTACCACCGCAGACTCCAGCGGGTCTTCTACACCTCCGCGCTGGTCAGCGTCCGCTACGACCCGAACTCGCGGATGTTCTACGACCGCAAACGCGCCGAAGGCAAGAAGCACGTCCAGGCCGTGCTCGCGCTCGCCCGCCGACGCGTCAACGTCATCTGGGCCCTGATCCGTGACCGACGGTGCTATGAGGTCACACCTCCGGTCACCGAGGCTGCCTGACTGCTGGGCACGCATAATCACAGTCGGCCCATTTCCCGCGCGGCTATCCTCCACGGGATGCCACTTCGCCAGTACGCCTACTTCGCACTGTTCAGCCGGCACACCACGGCAGACGACATGGCCTCCGAGCTGGGCATCACCCCTGACGAGGTGACTGTTCGCGGAAGCCGGTTCACCGAGCCGGCGGTGGTTCCGGTCGACCACTCGTGGATGGTTGTCTGCCGGGAGCCGGGTCTGCGCGTCGACGAGCAGATCACCTGCATTCTCGACAGACTTCAGCCCCACACGGACCGCATCTGCGACCTCACCAGACATCTGGCCCGCACCGGCGGCGGAGCAGTGCTTCAAATCGTGCGCTACTTCAACGACACCGACCAAGCCCACCCAGGCGCAGCGGACGCCCCCAACCTCTTCGGCTGGCACTTGGACCGCAAGGTCCTGGACTTCCTCAACGCCACCGGAGCCGAGCTCGACATCGACGAGTACGACATGGCCGGAGCCGAGGACACCACGTGAGCACATGACCCCGTACTCACCTCGCACATGCGTCGCACTCCGACGGCTTGACAACAGCATTAGGAAGCGTGCTGGTACTGGTGGAGCGTGTGGGTGCCGGAAATCTGTGTCACCCCTATGCGACCTGCGTGTATTCGTGGATGAGGCCGCCGAGTCGATCGCGTCGATGGATGCGAGCGTTGTCGGTGGCGGTGGGTGGTTCGGGTTCGGTGAGTAGGTCCGGCGGCCGTTGTCCGAGGGATCGGTGTGGCCGGTGTTGGTTGTAGTGCTTCGCGTACTCACTGACGACGAGGCGTAGGTGGCGCTCTCCCGTGATCAGGATGCGGTCGGTCGCCTCGCGTCGGCATGATCCGATCCAGCGTTCCGCGATGGCGTTCATCCGCGGCACCCGGGGCAGTGTTGGAAGGACGTGCACGCCGAATTGCCTGGAAGACGGCGTCGAAGCTGTCGGTGAAGTAGGCCCCGCGATCCCGGATGAGGAACTTGATCGACTTGGCATGGTCGCCGAGGTCCATGAGGTAGTTCCGTGCTTGCTGGGTGATCCAGGGGCCGGTCGGGTGTCGGGTGATGCCGGCGATGTGCACACGGCGGGTGCCGTGGTTGATGAAGAACAGCACGAACCAGCGCCGCAGGAAGACCGTGTCGATGTGGAACAGATCGGTGGCTACGATCGCGGAGGACTGGGCTTTGAGGAAAGCGGCCCAGGAGCGGTCCACGCGCTGCGGCGACGGGTCGATCCCTGCTTGCTTCAGAATGGACCAGACGGTGGAGGCGGCGACCTTGCGGCCCAGGCCGAGGAGCTCTCCGTGGACGTGGCGGTATCCCCATCCAGGGTTCTCCCGCGCCAAACGCACGACCAGTTGCCGCAGGGCCTCTGGTTTGGGTGGTCGGCCGGGGCGACGGGATGGGTGGGTCCACTTCCATGCGATGTGCCGTGCGTGCCAGCGAAGGACCGACCGCGGAGAGACCAGCAAGGCCACCTGGGTACGCCGCTGCGTGCTGACGATCCGGAGCAGTGCCGCCATGACGGCCCTGTCGCTCCACGAGAAGCGGGGCCGTGGCTGGGCACGGCGTGCTATGGCGAGCTGATGCCGGAGCATCAAGATCTCTGCGTCCTTCGAGGCATCCGAACGGGCGAGCAAGGCAAGCCATCGGAAGGTCTGGCAGGCGAGCAGGTAGATCAGCCGTATCACCACGACCAGCACGCTGCCTCAAAACGGCTCGCCGCTCCCGAGATCTGGGCAGATCCGAACCAGCAGGTCAGCCGGGGTGACATAATTCCCGGCACCCACACGTTCGCTTGTGTTTCGCGGTCTTGAGTGATCAGGTTCCGGCGGTGGCCCAGGCTGTGAGGACGGCCTGGATTTCTTCGGGTTGTGCCTGGTGGGGGTGTGGGCCGCGAAAACGGTGGGCGATGATTGTGCGGCGGAGCTTGGCTGTCATGTCCTCGAAGGAGGGCTGGGTTTTGGTGGTGTACCAGCGGGCTCTGGCGCGGTGTTCGTCGGTGTCGGCGGGTTGGTGGCCGGCCAGCGCGTGCCAGGTGGTGACCACGGTGCAGGCGAGGAGACCGAAGGGGACGGTGCGTTCGACTGCGCGGTGGGTGCGGTTGCGGGCCTCGCCGACGCCGAGGGTCTGGCGGGCGTTGAAGAAGGCGGTCTCGATTCTCCCAGCGGGACGCGTAGCGTTCCACGATCTGTTGGGCTGGTGTGGTGAGGTCGGTGGTGACCAGGGGCGGCGCCGTAGCCGCGGTCCCGGCTGGTGCCGGGGCCGCAGTTGCTGTCCCAGACCAGTACGACCCGGACAGGTTGGGTGTGGAAGGAGCCGTACCACAGGCAGGTGCGCTCGGCGAGGAAGACGGTGTCCACGCGTCCGTAGCGGCGGACCTTGGTTCGGTGCCGGTCCAGCAGCTGGGAGAGGTCGGTGGGTGTCCCCAGGCGTGGGCCGCGGGTGCGCGGGCGTCCTTTCTTGCCCGTGCGTGGGGGTGGGAGTTCGTGCAGTACGGAGGTGACTTTCAGGCGGCTGGTCCAGGTGATCTGCGGGTGGAGGCCGCGCAGGTGCTCGCCGGCGTAGGCGGCATCCGAGACTGTGTGCAGGGTGCGGTCGGGGAAGTGGGTGGCGAGCAGTTCGGTCATCTCGCGGGCCAGCGCGATCTTTGCGGTGTGTCTGGGGCGCCATAGGCGGGCCAGGACCGGCAGGCACACCGGCCGGGTCAAAAACGGCACGGTCACCACGATGCCGACGATGACCCAGCAGTTCCCGAAGCCGGCCGGGCGCGGCCCCCTCGCGGCGCCGTCGTGCTGCCAGGCAGCGCCGAACACCTTCTTCCCCGACCGTTTGAACAGGGTGTCATCGACCGCGACCTGCAGCGGTGCACCGTCCGGGAGAAGACGTGCCACGACCAAACCTGCCAGGGCCAGGCCGACCTCGTCGGCCGACCAGCGGGCGGTGGAGAACAGTCGGTGGCACCGGGCGTGGTGCCACACCCGCTCCAGCCCCGTGCCCAGCAACATTCCGCACACTGTGCGGCGGCGGGTCTGCGCGATCAGCCCGGTCAGCAGAACTCAGAACGCGCGGAACGTCGGAGTGGTGAAGCAGGGACGGCAGACAGCCAGCAAAGCGGATAAGGACGGCGGTATCGTGCCCACTGGAAGCATCGGCGGATCACTCTCCACTGGGTGAAACAGACACCGCCGATGCTTCTGTCTACCTGTCACATTCCATGACCAGTACGGTCTCGCGCCACCCAATCGAGCGCATCAACGCACACCCGTCCACCGACCCGGTGATCCCAAAAGTGCGAAACACGAGCGTTCGAGCAGGGCCGACGGTGCGTCGGCCACCCATTCACTCACCGCGAGCAGGGATCGCGCTCCGGCGAGGACCGCGCAGGCCGTCAGTGCCAGGAGCGTCACGAGAGGCGTACTCCCCGCGGATCCCGCGGGTCCGGGACCTGCGCGAGGCGTTCCAGCAGATCCGGAAGATCGCTCCCGGACACTTCCGGATGCGGTCTGAGCTGTTCAAAGGCAGGGGAGATCAGAGATGATGCGTCGGCAGGCACGGGCAGTCCAAGGTCACAGAGCGTAGAGAACTCCATGATCGCGGACGTCCGTGCCTGCTGTGTACCGAACCCCGCCCAACATGACGAGACGTCAGCAACCGGGCGTCAGCCGACTACGCCGAAGTCCTGACCGGAGAGGGCGCGGCAGTACGCGACTTCCGGTTCGCGCTCCATCCAGATGTTGCCGGTGGGGGTCTCTGTTGTTGCGTTGTCGGACCATCCGGTTGGTTTCCGCTGCGCTCTTCGAGATGCACGACGAATGGATCGCCTTACCGCGCCGCCACCTCCCCGAAGGTGATATGGGTAATATCTGCCGTAAACTCTCTTTTAGTTCCTCCGTGCTACCCAACGCACCTCAATGCAACCGCCAGTTGATCCCCAACAGCATGACGAGGGGCAATGCCTGGCGGATGCGTGTTCCCGGCCGAGTGGCACTCGCTTCGGTATCCTCCCGTGCAGGTCATCGGAGGCCATTTACCCAAAGATTACTGGGCAGTTGACCTCAGGGTTTCGTGGTAGCGTCCTTGTTCGGAGGGACAGTGCAACCTGAAAGGGAAATTGTGAACACGGAGAAGATCGCCGCTCGCCGCCTCTCGCTGGAAGAGGTGACGAAGCTCGGCGTGAAGGACAGGCTCTTCATTTCTGCCGACACGGCAGAACTCAAGCTTCCCGACTGCTATGTCCCTGCTTTTCTGACCAAGTCCGGTGAGGATTTCGAGGGCGGCTCGATCACGGCGAGAACCGTATTCCAGGAAGAGGTCTCCTGCCTTCCTGACGACGAGAATGAAGCCGGAATCTACTTGGCTGACGAGAACGGCTCGGTGACCATCGAGGTCCTCCAGTCCGCCGGTGTCGTGCTGGACCTGGCACTTTTCGTCCCTGGTGGGGACAAGGGGGCCCTCACGGCCCTTTACGCTGCGGCCCGGCAGGCCTTCGGCGCCGACGTCGTGCAGATCTGGCGCCAGGGCCTCAAGGAGGTTCCCGACGTGAAGGTCGACATCTTCGAGGAGCAGATTCCCCGGGGGCGCAAGGGGAGCGACAGCCCCAAGCGTGACCGTCGCGCGCTCGACACCTACCCCACCCGTGCGGACTTCATCGAGTTCTCCGCGGGGTGGAAGCCGGTCGTTGAGATTCACAGGCCGATTGTTGACGACACCCCGACCATCTGAGGCGGCGTTACCTCTCGGTCTCGGCCTGAGAGAACGCCGAGAACGCATGCGCCGGACCCGGTCGACCCCTGAGCGGCCCAGGGAGCCGTCGGAAAATAACTCACGAACGCCGAAGCGCCGTTCCAGTCGATGACCTCGCGAGACAGCCCGCCTGACCAAGATCACAGCCTGAAGTTATTCTGCGACAGCCCTCAGGGCTTCGGCGTAGTCGAGTGACGTCCACTTCGTGCTCAGGCGAGGCCGAGGAGTGTGAGGGGGCGGCGGGCGTCACGCGCATTGCGGCGACGGCCGGAGGCGATGTTCTTCGAGGTTGCGCCAGGCCGCCATAGCGCGGGGTGCGCTGTCGGTCCGCCACCGCGCACGCGGTCAGGTCGAGGACGACGGCCAGCGCGTGCCGCACTCCTCGCAGCCGGATCATCTGCTATCAGCCTGTGGGGGCCGGAAACGGTGTCACCCTATGCGACCTGCGTGTATTCGTGGATGAGGCCACCGAGCCGATCTTGCCGGGAGACTGTTGTGCTGTCGCTGGCTGACCGCGGTTCAGGGGCGATCTGCGGGGCTGGTGGTCGTTGTCCGAGGGATCGGCGTGGGCGGTGTTGGTTGTAGTGCTGTGCGTATTCGTTGACGACGAGGGGGAGGTGGCGTTGTCCGCTGATCAGGATGCGGTCGGTGGCTTCGCGGCGGCATGATCCGATCCAGCGTTCTGCGATCGCGTTCATCCGGGGTACTTGGGGCAGTGTTGGAAGGACCCGTGTGCCGATCGCCTGGAAGATAGCGTCGAAGCTGTCGGTGAAGTATGTGCCGCGGTCCCGGATGAGGAACCTGATCGACTGGGCATGGTCTCCCAGGTCCATGAGGTAGTTTCGTGCTTGCTGGGTAACCCATGGGCCTGTGGGGTGTCGGGTGATGCCGGCGATGTGTACGCGGCGGGTGTCGTGCTCGATGAAGAAGAGAACGAACCAGCGCCGTAAGAAGACCGTGTCGATGTGGAACAGGTCTGTTGCCACGATCGCAGTGGCCTGCGCTTTGAGGAAGACAGACCAGGAGCGGTCCGTGCGCTGCGGTGACGGGTTGATCCCGGCCTCCTTGAGGATCGACCAGACAGTGGAGGCGGCGATATTGCGTCCCAGCCCGACGAGCTCACCATGGATGCGGCGGTATCCCCATCCCGGGTTCTCCCGCGCCAGCCGCACGACCAGTTGCCGCAGCGCCTCTGGTTTCGGTGGCCGACCTGGTCGACGGGCCGGGTAGGTCCACTTCCAGGCGATGAGTCGTGCGTGCCAGCGCAGGATCGATCGCGGGGTGACCAGCAGGGCCTGTGCCGTTCATAAATGCGTCGCTGCAGCTCATTGCGGATCTGGTGGACCTCGTGGGCAGGCTGGGATCATGCCCGGGTGATTGTCTCGCTGGTGTATCAGGTGACGCGGAGGCTGCTCTCCGTTCCGGCGGTGCTGTTACGCAAACAGGGAGGCAAGGACGCCTGTGGGTGCCGGAAAGTATGTCACTCGGGTTGACCTGCCGGTTCGAGTTTGCCAGAGCTCGGGTGGCTGCAGGCTGTTCTGGGGCAACATGCGGGGCGTGGTGATACGGCTGATCTACCTGCTCGCCTGTCAGAGGTTCCAGTGGCTTGTCCTCCTGGCCCGCTCGAGTGCGGCGAAAGATGTCGAGATCTTGATGCTCCGGCATCAGCTCGCCATCGCGCAGCGCAACCGGCCTCGGCCTCGGTTCTCCTGGAGCGACAGGGCCGTCATGGCAGCTCTGCTCCGGATCGTGAGCAAGGAACGGCGTACCCAGGTGGCCTTGCTGGTCACTCCGCGATCGGTTCTGCGCTGGCACGCACGGCTCATCGCTTGGAAATGGACCTACCCCTCCCGTCGTCCTGGTCGACCACCGAAACCAGAGGCGCTGCGGCAGTTGGTCGTGCGTTTGGCGCGGGAGAACCCCGGATGGGGATACCGCCGCATCCAAGGAGAACTCCTCGGTCTGGGACGCAAAGTCGCCGCCTCGACCGTCTGGTCGATCCTGAAGGAGGCCGGGATTGACCCGTCGCCGCAGCGCACGGACCGCTCCTGGGCTACCTTCCTCAAGGCCCAGGCCTCCGCGATCGTGGCCACCGACCTCTTCCACATCGACACCGCCTTCTTGCGGCGCTGGTTCGTGCTGTTCTTCATCGACCACGGCACCCGGCGGGTACACATCGCCGGCATCACCCGGCACCCGACCGGCCCGTGGATCACTCAGCAGGCACGCAACTACCTCATGGACCTCGGCGACCGCGCGGGGTCGATCAGGTTCCTCATCCGGGACCGCGGCGCGTACTTCACCGACAGCTTCGACGCCGTCTTCCAAGCGGTCGGCGTGCAGGTCATCCCGACACTGCCCCAGGCGCCCCGGATGAACTCAATCGCAGAACGCTGGATCGGATCATGTCGCCGCGAGGCCACCGACCGCATCCTGATCACCGGCCAGAACCACCTCCGCCTCGTCGTCAATGAGTACGCAGAGCACTACAACAGACACCGGCCACACCGATCCCTCGGCCAACGGCCACCAGACCCGCTGATCACACCTGAACCGCGGCCAGCCAGCGCCTCCACATCGGTCTCCCGGCGTGATCGGCTTGGTGGCCTCATCCGCGAATACAAGCAGGTCGCATAGGTTGACAGCGTTTCCGGCACCCACACCCCCGAGGCCACGTCGCTCTTCGGTAACGATCGGCCCCTGCTGACCAGGCTCTCGCGTCACCCCGTGGTCTCGTCGAGGACGACGTCCTCGACGAGACCACGCAGGTCACAGCCTCGAGCGAACGATCAACTCAAGATAAGCAAGGGCCACGTCTACGGAACCGTCGTGATCGATGCCGAGACCCACCAGGTCCTCGACCTGCTGCCCGAACGTGACGCGGCCACCCTCGCCCCGTGGCTGCGGGCCCACCCCGGCATCAAGGTCATCTGCCGTGACCGCGCCGGCGCCTACGCCGACGCAGCCGCCACCGCCGCACCCCAGGCTCTCCAGGTCGCCGACCGGTTCCATCTCTGGCAGAACCTGGCCGTCGCGGTCGAGAAGACCGTCGCCGCCCACCGCTCCTGCCTGCGGGGCCTGCCGCCGGCCAGCCCGGAATCCGAGCCCGAGTGGGAGACGCCTGTCGAGGCGGCCCTAGGCCAAGGCGACGAAGCAGATGACCCGACCGGCAAGTTCGCCGAGCGGGCCCGCACCCACCACGCCCTCGTCCACGACCTCCTCGCCCAGGGCATGGGTCTGCGCCACATGGCCCGCCACCTGGACTGGGGACGTCACACCGTCCAGCGGTACGCACGAGCCTCCCGCTGGCAAGACATGGTCAAGGGCCGCAAGCGCCAACTACCCAGCAAACTCGACCCGTTCAAGCCCTACTTGACGCAACGCTGGGCCGAGACCGATGGAAGAATCACGGTCCTTGATCTCCACCGTGAGATCACCGCCCGCGGCTTCCACGGCCACTACTCCACCGTCCGCGACTGGGCCCGGCGCGACCTGCCGCAGCGGGAAGGCATCACGCCTCCTCCACCACCGCCGTCGGTGCGACAGGTAACCGGTTAGCTCACCCGGCACCCGGCCGCCCTCACCGAAGAGGAGAAACTGCACCGAAAAGCCGTGCTCGACCACTGCCCCGAGCTGGAGACCACCGCGTGCCTGGTCAGCTCGTTCGCAGAAATGCTCACGACACTCCGCGGCACCCGCCTGCCCGACTGGGTCAACGACGCCACGGACGCCAATCTGCCCAGCATCAGCAGCTTTGCCGTCGGCCTGCACAGCGACTTCGACGCAGTGACCGCCGGACTGACCACCGACTGGAACTCCGGCCCGGTCGAAGGAGCCGTCAACAGGATCAAGATGCTCAAACGGCAGATGTTCGGCCGCGCCGGCTTCGGTCTCCTGCGTAAACGAGTCCTACTGGCCACGTGA

Protein sequences of DBSCAN-SWA_5

>NC_016582|10315826:10342311|10317060_10318713_-|WP_014181263.1|DBSCAN-SWA
MSNPAPTSLPVDDSWWRSAVIYQVYIRSFADGDGDGTGDIAGLRSRLPYLAHLGVDAIWINPWYPSPLTDGGYDVSDYRDIHSTYGTLDEAKQLITEAHELGLRVILDIVPNHTSDQHAWFQQALAAGPGSPERDRFVFRNGKGEDGSEPPNDWHAAFGGRTWTRTDDGQWYLHLFAPEQPDLNWDNPEVRAEFESILRFWFDLGVDGFRIDVAHGMVKDPALPDLGLTEFSVLTGEGQQDHPHWDRDGLHDIFRSWRAIADSYPNPRVFVAEAHVRPGRMPDYLRPDELHTAFNFDFLKCPLEAGKLREVIDRSITSLATVGAPATWVLSNHDETRHVTRYGRADTGVQALFRNQPIPTDLALGTRRARAAALLMLALPGGAYIYQGEELGLYEVEDIPEELLQDPTWERSGHTVRGRDGCRVPLPWTGDTPPFGFSTTGATPWLPQPEDWKTYTAEANQADPTSMLQLYRSALSLRRTHPGLRGEDFCWLDSPAGTLLFERGNGVLCAVNLSDQPIPLPAGSSPLLVSGPLSEDGLLPPDTTVLLYRD
>NC_016582|10315826:10342311|10315826_10316924_-|WP_014181262.1|transposase|DBSCAN-SWA
MLLRLAYLGVSNAFAMLRLLPMTDRDKDAEIRALRHQITVLERQLGKDKVRFTPSDRAYLAALLHRMPLHVLRRLRLLVRPDTVLRWHRSLVARRHAAACRPKRPGRPRTVRSIRVLVLRLAKENPSWGYRRLHGELLVLGVKVGASTVWEILKEAGIAPAPERTSSTWATFLRAQADALLACDFMETVTLSGVRMYVLVVIEHGSRRIRVLGATAHPSASWVAQAAKNLVMDLEDLGRRARFMIRDRDGKFPALFDAVLKDAGIDVVLSGIQMPRMNSITERWIQTCRRELLDRTLIWNQRHLLHTLREFEQFYNGHRPHQGIANARPLHPLPPPIDNPDALARLEIRRHDRLGGILHEYRDAA
>NC_016582|10315826:10342311|10341984_10342311_+|WP_078610744.1|transposase|DBSCAN-SWA
MHRKAVLDHCPELETTACLVSSFAEMLTTLRGTRLPDWVNDATDANLPSISSFAVGLHSDFDAVTAGLTTDWNSGPVEGAVNRIKMLKRQMFGRAGFGLLRKRVLLAT
>NC_016582|10315826:10342311|10326937_10328134_+|WP_014181271.1|DBSCAN-SWA
MVGPAAAQGATPAADASAVQAGQSCTAADLGKRHPFIKSTEVAPTITHFKGWYVTAGSTGYQNVTTSTQTTISVSVGLNGEIKGDFAVEALGTVGAMLGLNVQVNYSSTSSESTSVSWNFNDPGYYGVYKGTKKVTGTYGSLNCNRVQQGDGSWALKWIEGPDSGSYTTYTTLEEGAVRCEDKVPANSIMRKAQGLLDCETPPRAGHAPGPVASAKATAARNAAAKDTAKGTAGKAATARTSAPATRAALNCQPDVYRIHVPGKPLNWSAPVLANDGIRLRESNWTSAHLDNWRLCNVTERNGVIEASLWNWGNGGCATIPANIANQEQAYLTTAPCGEDDLQRFYIYRDVPGGSKIGLQNKYTGSMLGHDRYADGELIRQYSSGRQDGTGTYDLVKV
>NC_016582|10315826:10342311|10340286_10341024_+|WP_193383817.1|transposase|DBSCAN-SWA
MRLARENPGWGYRRIQGELLGLGRKVAASTVWSILKEAGIDPSPQRTDRSWATFLKAQASAIVATDLFHIDTAFLRRWFVLFFIDHGTRRVHIAGITRHPTGPWITQQARNYLMDLGDRAGSIRFLIRDRGAYFTDSFDAVFQAVGVQVIPTLPQAPRMNSIAERWIGSCRREATDRILITGQNHLRLVVNEYAEHYNRHRPHRSLGQRPPDPLITPEPRPASASTSVSRRDRLGGLIREYKQVA
>NC_016582|10315826:10342311|10318756_10319599_-|WP_014181264.1|DBSCAN-SWA
MPERTQTVRTLRRRAPGLVLIAAAGLYSVVPLLSMVSAALAPQGTFPSGLSWPSDPHWHNFVDAWSIANITTLLKSSTLIVLGVVPVAVLIATMAAYAIAVLEIPLGRVFYTILVLTLTLPYEIVIVPLYEQTKAMGLLGTQWALILPLIGMNMPFAVFWMRAHFIGVPKELSEAAGIDGAGPWRALFHIHLPLARPAIASLALLMFLSTWNQFLLALVLIDDPDKRTMAGALQAFTTKYSTDQVLLNAGALLIMAPTILVFLFLQRHFVKALLQGSVKG
>NC_016582|10315826:10342311|10319601_10320519_-|WP_014181265.1|DBSCAN-SWA
MPSTRPTREGTAARGRRRLWARRWAGWLFALPALAFYGIFNFYPVLLSIQYSFYDWDGIGASTWVGLKNYTEVFTDSEQFSSLLHAFYLILFFTVLPVTLALITASVLRQLQGRFTGALARTLLFLPQIIPGAAAGVAWTWMYSANGVVNQTLRAVGLGSLARAWLADFDWALTAVGFIGTWLSTGLCTMLLLAGIGKIDNSLYEAARIDGAGPIRQFLAVTLPGLRNEIGVCVTITIIAALASFDVVYLATQGGPGTQTMVPGVAVYNLAFSDSRLGAASALAVVLALIVIAVVAPLQRLFREK
>NC_016582|10315826:10342311|10329996_10330353_-|WP_043488027.1|DBSCAN-SWA
MTNTRTDREHRELLRLTDATTALDQARSLVRDGTPKPGNERLLALAYCMLTFGEMLKQASHGIVTQAYSGPIALRDKLAHVPHRKLNAEVLATSVERATTEILPLIQARIQDLSNAVS
>NC_016582|10315826:10342311|10330349_10330619_-|WP_014181276.1|DBSCAN-SWA
MRPATTAKLRANATTIHQLGRRHGLHSFALSTEPGELVATLDPNRSYFDITSFEKDLSSILGALVEVVPRGPGVEVEETEPLNDLRGAA
>NC_016582|10315826:10342311|10341114_10341945_+|WP_078610743.1|transposase|DBSCAN-SWA
MVSSRTTSSTRPRRSQPRANDQLKISKGHVYGTVVIDAETHQVLDLLPERDAATLAPWLRAHPGIKVICRDRAGAYADAAATAAPQALQVADRFHLWQNLAVAVEKTVAAHRSCLRGLPPASPESEPEWETPVEAALGQGDEADDPTGKFAERARTHHALVHDLLAQGMGLRHMARHLDWGRHTVQRYARASRWQDMVKGRKRQLPSKLDPFKPYLTQRWAETDGRITVLDLHREITARGFHGHYSTVRDWARRDLPQREGITPPPPPPSVRQVTG
>NC_016582|10315826:10342311|10324577_10325915_-|WP_014181270.1|DBSCAN-SWA
MKRASRLLAAIAALALTAALLALGASPAAAASPKPPASAPGIEYTAKPGDGAQRSSNGKGTAEMPISPDNPAGTEWLNDCLGSSDAQDPDGRVYNRFKWCQEYEFKNRYYKKVDGKPVLKGTNTIKFQAAAIGYNDTRATRVFFRAKTGQVNYDGWNPLEKRTVAPNLKLEITPECVPGANQPTTATCGVGRSPAKMEWAQWSNFPDWVYWDVSSIGGEGQDQVAFHQWRLYMNGASPGYEQSTERGEGPPIGIRCDSADYFTHGVKRYPHACIYTGALPFLTYDGNHPNIRQHIRDAQNAPATDGVTYPKENHPKKVPGKWSPTAGARGAPLHRVVSRGQGGAIALANEEVKKAACGQKGGSNPWGPDYNAATGLPPYNTSVDDCDEYPFSSTYEGASSIEWDFSVRNIEKGENRSAGTNLSNFYVDDRILAWPVEDPYWVNVD
>NC_016582|10315826:10342311|10333680_10334139_+|WP_014174217.1|DBSCAN-SWA
MPLRQYAYFALFSRHTTADDMASELGITPDEVTVRGSRFTEPAVVPVDHSWMVVCREPGLRVDEQITCILDRLQPHTDRICDLTRHLARTGGGAVLQIVRYFNDTDQAHPGAADAPNLFGWHLDRKVLDFLNATGAELDIDEYDMAGAEDTT
>NC_016582|10315826:10342311|10320524_10321907_-|WP_014181266.1|DBSCAN-SWA
MPKQQHPTSPARIVGRRLRAPLAAVAAASALATLAACSGPGSGSGSSADATPTAVNTAVGGTPATLTLFSGAGLEKYEQGLADAFMAKYPKLKLKLRVEADNNYNTVLPRLLASDSAPDIAAPNDLLGGVKDGLLTNLDAYDKAYGWSKKVPASALAPGRVSKGVIGSGALYLAGGSAGPLTGVFYNKELAAKVGMKTVPASIAELDAVMAKAKKSGITPIVASNQDGLIGHLYNLLLGDYMGAQKLSDIVYHKPGATLDTPEALKATKTLQKWIKKGYFASDVNAINQEASYGQFTGGKGLFFFQGSWITQTIDKTFKGKYGVFPMPPAEKGGKYAGMTSNTLAYSIAAHSKHKDAAALFLNFLTTPEAAKVAVDNGYAAVTSDSGKTPSLSGTLTEQIQTGYAAIAADNGFDSWIQNAAPAVNTKLPQQLQLLVSGKVEPAAMVKTLQATYADAVKDN
>NC_016582|10315826:10342311|10323241_10323733_-|WP_193383816.1|DBSCAN-SWA
MTADDVLSILAVLRNTDADVWIGGGWGIDALLGDQTRPHRDLDLMHREDQEPAVLAALEEAGYVETLDGRPVRFVVADPSGREVDLHPLTFAADGSAVQASPDPGRPFVYPVSCFVTGTIRGTAVPCLSPEQQVYFHQGYEPTDRDRHDMARLRQAFGIATHF
>NC_016582|10315826:10342311|10335578_10336658_-|WP_158502600.1|transposase|DBSCAN-SWA
MCGMLLGTGLERVWHHARCHRLFSTARWSADEVGLALAGLVVARLLPDGAPLQVAVDDTLFKRSGKKVFGAAWQHDGAARGPRPAGFGNCWVIVGIVVTVPFLTRPVCLPVLARLWRPRHTAKIALAREMTELLATHFPDRTLHTVSDAAYAGEHLRGLHPQITWTSRLKVTSVLHELPPPRTGKKGRPRTRGPRLGTPTDLSQLLDRHRTKVRRYGRVDTVFLAERTCLWYGSFHTQPVRVVLVWDSNCGPGTSRDRGYGAAPGHHRPHHTSPTDRGTLRVPLGESRPPSSTPARPSASARPATAPTAQSNAPSPSVSSPAPWSPPGTRWPATNPPTPTNTAPEPAGTPPKPSPPSRT
>NC_016582|10315826:10342311|10328220_10329288_+|WP_043488025.1|transposase|DBSCAN-SWA
MLVRMVYLIATRIFTWLVLLSRTSVAKEAEILILRHEVAVLRRQVAAPKPSWPGRALLAALARLLPRALRQHRIVSPRTLLAWHQRLIKDKWRQPASPGRPPMPEELRDLIIRFGAENPRWGFRRVHGELRRLGHSVSQASVRRTLRAAGLGPAPRRHPVRGEWAAFIKTQAHGLLATDLFHVDTISLRRLYVLFVMEVRTRTVHILGVTAHPTAVWATQQARQLIWQLGQRAGDFTHLIRDRDAKFTAAFDAVFASEDITVTKIPPRSPNCNPHAERFVRSVREECTDRLLIFDRGHAEKILHDYARHFNAHRPHQGRNQLAPLDDPNVISLPAARIQRRQAVAGLINQYHRAG
>NC_016582|10315826:10342311|10322209_10323229_+|WP_014181267.1|DBSCAN-SWA
MAQSSQKINMADVARAAGVSMATASRALNNENGVAEATRRRVLAVAEELSYVVSPEASRLAGGDTGRVAVVVPHISRWFFAALLEGLESVLRAADLDVLLYHVDGIEDRHDFFHRLPARRKVDAVVVLAFPVGEEEQRRLGLMGVTIIAAGGQHAPYPNVSINDETAGRQAMDHLLFLGHRRIAMIAAVDPDQPDEVQPSGRSNAYYAALRDAGIPLDERLVVTVDWGGDQGADAMAKLLSRPEPPTAVYAHSDEVALGAIRTLRRAGLRIPEDLSVIGIDDHPVAELTDLTTVRQPVREQGELAGRMLLSILRGEETEHDVVVPTQLVIRGSTAPPRS
>NC_016582|10315826:10342311|10337757_10338366_+|WP_014181278.1|DBSCAN-SWA
MNTEKIAARRLSLEEVTKLGVKDRLFISADTAELKLPDCYVPAFLTKSGEDFEGGSITARTVFQEEVSCLPDDENEAGIYLADENGSVTIEVLQSAGVVLDLALFVPGGDKGALTALYAAARQAFGADVVQIWRQGLKEVPDVKVDIFEEQIPRGRKGSDSPKRDRRALDTYPTRADFIEFSAGWKPVVEIHRPIVDDTPTI

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014181262.1|10315826_10316924_-|transposase	transposase	NA	NA	NA	NA
WP_014181263.1|10317060_10318713_-	glycoside hydrolase family 13 protein	NA	NA	NA	NA
WP_014181264.1|10318756_10319599_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_014181265.1|10319601_10320519_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_014181266.1|10320524_10321907_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_014181267.1|10322209_10323229_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_193383816.1|10323241_10323733_-	amino acid transporter	A0A2K5B286	Erysipelothrix_phage	2.2e-19	34.2
WP_014181270.1|10324577_10325915_-	hypothetical protein	NA	NA	NA	NA
WP_014181271.1|10326937_10328134_+	hypothetical protein	NA	NA	NA	NA
WP_043488025.1|10328220_10329288_+|transposase	transposase	NA	NA	NA	NA
WP_043488027.1|10329996_10330353_-	hypothetical protein	NA	NA	NA	NA
WP_014181276.1|10330349_10330619_-	hypothetical protein	NA	NA	NA	NA
WP_014174217.1|10333680_10334139_+	DUF4279 domain-containing protein	NA	NA	NA	NA
WP_158502600.1|10335578_10336658_-|transposase	transposase	NA	NA	NA	NA
WP_014181278.1|10337757_10338366_+	hypothetical protein	NA	NA	NA	NA
WP_193383817.1|10340286_10341024_+|transposase	transposase	NA	NA	NA	NA
WP_078610743.1|10341114_10341945_+|transposase	transposase	NA	NA	NA	NA
WP_078610744.1|10341984_10342311_+|transposase	transposase	NA	NA	NA	NA

Sequences of DBSCAN-SWA_6

Nucleotide sequences of DBSCAN-SWA_6

>NC_016582|10633537:10646120|DBSCAN-SWA
GATGGCGGGGGAACCAGCGGGAGAACCAGCGGGCGACCGGTATCCGCGGCCGGTGGTGTCGGACGCCGAGGCGGAGTGGGTGTGGCGGCTGCTGTCGGTGCAGGCGATGGAGCAGGGCACCCGGCCGGAGACGGTGCGGCTGGCCGTGGTGGTCGGGCTGGCCCGGGCCACCGGCGCCCGGTACGGGGACCTGCTGCGCTGCACCACCGACGCGCTGGACCTGGACGCGGGCTCGGTGGCCGTCGAGCACGGCAAGCACCGCGTCCCGCGCCGCCACGGCCTGGATCCGGGCACGGTCATGGTGCTGCGGCGGTGGCTGCGGGTGCGTCAGGAGCTGTGCGTGGAGCTGGAGGGGACGGTGCCGAGGGCGTTGCTGCTGACGGTGCACCACACCCATGACAACGGGGTCACGGTCGCCGCCGGGCTGCCCATCACCCGCCAGGGCCTGGTGCTCTCCTGGCGCCGCTTCGTCCACCGTACGAACGCGACCTACGCCGCCCGGCGCCCCCCGCTGCCCACCCGCTTCGAACAGCTGCGCCGCGTCTGGTCCACGGGCTGAGCCGCCGGGTGCCGGGCCGTCGGGCGCCGGGCCGTCGGGCGCTGGGCTACCGGGCGCCGGGCCGCCGGGCGCCGGGCGTCACCTGTCACCGCCGGCCGAAGAACTCCACCTCGGCGATGGCCACCCGGCGATCGGACCGGACCCCGTACGCGCCGCCGACCGTCAGCCGTACCCGAGTGACCTCCGTCCCCGGGACGTCGAAGGTCTGCTGGCCGGGTTTGTCGTTCAGCTTGAGGGTCTTGGTGCTGCGCTTCCCCTCGGAGGAGACCAGCGTGACGGTGAGTTCCGAGGGCCGCGCCTGGGTCAGGAACTCGGCCTCCTTCGCCGAGCTCCCGGAGGTGATCAGCAGCTTCAGCAGCCGCACCGGCTGGTCGAAGTCGGCCTCCAGATACTGGCCGTCGGCGGGGCCGCCGGTGGCGGGCGCCCAGTACTTGTTGTTGTAGCCGTCGAAGGCCGCATGGGCCGTATGCCCGGGTGCCTGGCTGGAGCCGCGGAACTGATCGGCGTGCAGCGGTTTGGGATCGCTGGTCCGGTCCTGGGTGAAGGTGAACAGCTCCGAGAGCTGCCCGCGGCCGAACCAGGCCGCCGCGGCCAGAACGAGCAGCACGACCGGCAGCAGCAGCCGGGGCCGCGGCCGGCTCCTGAGCCGCGGCCGGTCCCCGGCCGTCAGCGGGCGCGGGGCCCCGCGCCGGAAGATCCGCCGCCACCAGGGCAGCGGGCGGTTCGCGGCGGGCGCGGACGCGACATCCAGCAGCGCGCCGCAGCGCACGCACAGCCTGCGGTCGTACGGGGTGTCCGCCCGGCACCGCGGGCAGGGGCGGCCCGGCCGGCGCGGTGCGACATCCGGGCGGGGCGGCACCGGCGGCGTGGCGGGGGTCGCCGGGGTGGCCGGAGCGGTCGAGGACTCCGGACGTTGGTGGTCCGGGCCCGCGTCGGGCGGGCCGTCCAGCGGATCTCCGGGCCGTCGAGGGGCAGCGGTCGGCTCCGGCGCCGCCCCCTCCCGCTCCCACTCCAAGAACGACTGGCACGAGGCACAGAACTGCGCCCCCGCCGCATTGCGATGTCCGCACTCGGGGCAGATCATGACGGCCCCGCCCCCTCCGTCGCGGCCACGATCTCCACCCGGTACGGAACGTGCGCCGGAACCTCCGCCGCGACCAGCTTCTCCACCCGCGTCCGGTCGAACTGCTCCGGATCGGGCACCCGCAGCCGTACCGTCACCCACGGCCGGGCCGAACCGGGCAGCGCCGCCCCGGGCTCGGAGGACCACGATGTGCCGCCGCTCTCACTGATCTCCGGCTCGATACCGGTCTCCACCCGCACCGCCGCCGCCAGCCCCTGCCGGGTGCCCCGCTGACGGTGGCGGGTCACGGCGGTGGCCACCACCGCCCGCCGCTGATTGACCGGTCGGTCCTGGTCCACCTCCACCGCCACCCACTGCGCCAGCCAGGCCAGCAGGTCCTCGGGGGCGGTGCGCGGATGCAGATGCGCGGGCAGGTTGTCGAGCGTGAGCAGCACCGGTGCCAGCACCTCGTCCAGAGCGCTCAGGAAGCGTTCGAGGAACTCCTCGCCGTGATAGACCGCCGGCAGCTGGTGGAGCAGGGGGTGGGCGGTGGGCAGCCCGGGAAGTGGTCCGCGCACTCAGGCCTCCCGTACCCGGAGCTGGTGTTCATAGCTGAACACCAGCGCGTGTCCGTCGAGTTCGATCTTGTTGGTCGCCTCGCCGCGCTGTCCCGTCACCGGGTCCGCCGGGAACAGCCGTACGTCCTCGACCAGATCCACCCCGGGCACCTGCTGGAGCACCGCGAACACCTCACCGGAGTGGACCGGCCGCCCGAACGGCCAGCCCTGTCCGTCCGGGCCGCCGGTTAGCGGGTTGAAGTAGCCGTACAGCGCGGTCAGGGCCTTGTCGCGGAGCCGGTCGGCGGCTGTCCCGCGGCTGGGCGATACGGTGGCGACCACCGTGACGCCCTGGTAGTAGGGCGGTTCGACGGACAGCTGGGCCCCGATCGGGCGCCGCTCCTCCAGATGGTCGGCCAGCCTGGCCAGGGTGGCCGGCGGTGGGATCAGGTCCTCGAACCGGATCCGGCCCTGCTCGTCGTCGCGGCCCGTCGGCACCACCAGCAGCCGCACCCCGCCCGTCTGCGCCCCGCCCGTCTGCGCCCCGTCCGTCCGCGCCCCGTCCGTGCCGCCCTCGGCCCGGTACTCGCCCGCCGGTACGCAGGCCACCCGGGCCGCGTCCGGCGCGAACTCGCGGGCCAGTTGCTCGTAGTCGTGCGGTACCACGGCCCGGTGCAGGGTGCGCAGTGTCATCGGCCCGCGCACCCGGGCGTCCTCGACGGTCTCGCCGTCCACCCCGCCCAGCGCCGGCCGCCGGTTCGCCACCCGCGCCACGTACGGCAGTGAGCTGCGCAGCACCCGCAGCGCACCGCGCGACACATTGCCGCGCCGCCCGCCGCCGGTGCGGTAGGCGCGTACCCGTACCGGACACCCCTTGGGCGGCACCGCGCCGAACAGCCGCAGGGTGCCATCGGCCTCCCGGACCGCCGGGCCGAAGTCCACCTGGCCGGAGTTGGGGTCCACGGTGATGTGCCGGTCGTACGGGGTGGAGTGCGCGAAACTGTCCACCCGGGTCCACTCCAGCCAGCCGGGGCCCTCCGCCACCTCGACCACGAACGGCTCCTCGCCCGCCACCACGGGCGGCCGGGCGACCTGGAAACTCTGCCCCGGCACCCCCTCGGACAGCCCGAGGACTTCCTCCACGACCTTCTCGGAGTGCTCGGCTTCCACCGTGCCGCCGATGGTGAACGCGCCGGCCTGACGTACCGTCGGGGATGCCACATATGTGGGCTGGTCCGGCGCGGCCTGCAGCAGCCGGCAGCGCAGCCAGCCCGCGGACTGCCGTACCAGCACCGAGCCGGTGTGGGTGGCGGGCACATGCAGGATGACCTCCCCCGCCTTGTTGAACCCGCCGGTGTCGTCCTTCTCCACCTCGCATGCCACCCAGGCGTTGCCGTCCCACGCCTCCCACAGCAGCGGCGGGCGGCGCGGGTCGACGCCCACCCCGTCCACCCGGCAGTCAAGACGCAGCACCACCGCGCAGCCGGGCACCGGATCGGACAGCCCGATGTAGAGGCTGTCCCCTGGAACGGGGGTCGGGCCGAAGCACGGTACGTCACGGCCCAGCGCCAGCTCCTCCGAGCGGTCGGCGGCGTTGCCGGAGGCCGGCCAGGTGGCGAGGTGGGTCAGCGCGCACGGCACCACCGAAAGGTCCCGGCTGGTGGTGAAGACCACCGCCTCCTCGGTTTCGGTGCGCACCGTGGCGATCTCCGTACCGGCCCTGATGCGCACCGGTTCCGGCTGCGGGGCGGAGAGCCAGAAGGTGGCGTCGGTGTGCGCCGCGGTCGGTGGATACAGCCGCACTCCGATCAGGTCGAGGAAGGCCAGGTAGTTCTTGTCCGGCACCCGGTTCAGCCGGTAGACGAGCTGGTCGACCATGGTGGCGAACGCCTCGATCAGGGTGACGCCGGGATCGGAGACGTTGTGGTCGGTCCACTCCGGGCAGCGCTGCTGCACCAGCCGCTTGGCCTCGTCCACCAGGCTCTGGAAGCGCCGGTCGTCCAGGTTCGGGGTGGGGAGCGTCATGTGCCCTCCTCGCTGGTCATGCGCGCTCCTCGGTGTGCGGGATCACGTAGAACGGGAACACGAGGTTGCGGGGGTCGTTGGCGCCGCGCACCGCGTAGCTGATGTCGATGTACAGCACTCCCTGGTCCGCCTCGTCGAACCGGACGGCGACCTCGGCCACTTCGATGCGCGGCTCCCACCGCTCCAGGGCCAGCCGCACCTCGTAGGCCAGCTGTCCGGCCGTACCGGCGTCGGCGGGCGCGAACACGTAGTCGCCCAGGGCGCAGCCGAACTCCGGCCGCATCGGCCGTTCGCCGGGGGAGGTGGCGAGGATCAGCCGGATCGACTCCTCGAGCTCCCGCTCGTCGCGGACCAGCGCGATGCTGCCGGTGGCGTCCGTACGGGGCGGGAACGCCCAGCCCGCGCCGATGAACTGCTGGCCCATGCCCGGTCACCCGCCGATCTGTACGCTCGGGCACCCGGCGGTGATGGGCGAGCCGCAGCCCGCCGTATCGCCCACGCGGGCCGCGGGCTGTCCGCCGATCAGGACGGTGGCGCTGCCGGGCGGCGCGATCTGGGACGGCGGATGGGCGGCGGGCGCACTGCACTGGTGGGGGGTGCCCACGGTGGCCGCGGGCCGGCCGCCGATGAGCACGGTGGGCTCGCCGGGCGGGCCGACCACGCCGGGGTGGCCGGTGGGATCGCCGACGCGTGCGGCTGCTGGCATGTGTGGTGCCCCCTGACTGTGCTGGTCGGTCCGTTCCGGTGGGCTGGTGTGCCGTGTCCTGTTGCTCTTCCGGGTGGTCAGTTGATCCGTACCAGGGGCGCGTTGACGGAGAGGGAGTTGCCGCCCTTGATCTCGGTGCGGTTGGTGCTGCCCACCGCGACTTGGGCGCCCTGCACCTCCACCGTGCCGCCGGTGGACAGCTTCACCTGGCCGCTGCCGCCGTCCACCGCCACTCCGTTGCGGGCCGTCAGCTTCACCGAGTCGCCGCCCAGCTCGAGCGGGCCCTTGCCGGCCTCCAGGGTCACCCCGCTGCCCGCCTTGATGGAGACCTGCTCCTTGGCCTCGATCTCGACCTTGCCGTCGCTGTGCACCACGATGGTGGTGCCCTGGCGATCGAGATTGATCTTGAGTTTTCCGTCGCCGGTGACCAGCCGCACCCCCTGCGGGCCGTTCGCGGCGTCGAGCAGTTCCAGTTTGTTGCCGCCGCGCGAGCCGAAGGCGCGTTTGTTGACCGCCCCGCTGGTGGGGTCGACCGCCTCCGCGTCCTGTCCGCCCCCCTGGCCCTGGCCCTGGCCCTGTGCCTGGCCGGGGCCGAGACCTTGCGGCCGGCCTGGGCCTCCCTGCCCCCCTTGCCCCGGCTTGTCCTTGCCGTTGTACAGACCGGCGAGCACATACGGCCGGTCCAGATGCCCCTGCTCGAACCCGACCAGCACCTCGTCGCCCACCTCGGGGATGAACGCCTCGCCGCCCGCCGTCCCGCCCGCCTGTGCGGTCCGCGCCCAGTCGCTGGCGTATTCGTCCGACAGCCACGGAAAACGCACCTTGACCCGGCCCAGACCCTCCGGGTCCTTGGTGTCGGTGACCGTGCCATTGGCCAGCCCCGAACACCGCGCACCGGTGTCCGTACCCCCGCCGGAGCCGCCGCCCGTCAGCCCGAACAGCGAGCGCTCCTGCTGCCCGGAGACCGTCACCCAGGTCTCGTAACCGCGCACCGGGTCGAAGACATGCCGCGAGGAGGTGACCGTATAGCGGCCCTCGAAGGGTTTGCCCACCCCGGCCAGCGTGACCGCGCCGCCCGCCCGTACCTCCGGATTGCCCCGGATCACCGCCTCCAGCTCGGCGAACGACCCCGCGATACGCGCCGCCAGCGCCTTGGCCGCCTGGTCCACCTGGGCCTGGCTGCCGTACGGGGCGTCGGAGACCACGAAACTCGCCTCGCCGAAGGGCTGTGCCACCTCCGCCGCCGTCAGGCCCAGGTCCAGTGTCGCCGCCTTACCCGCGTCGGCCCGCCCCACCAGCGGCTCTTTGGCCCGTACGTCCCAGCCACGCACCTCCACCGCCGACACCTGCTCGGCGGCGGACACTCCGGCCCGGCAGCGCAGCAGATTGTCGCCCATCTCCAGCACCAGCGGCTCGCGGGCGGCGCGCGCCGACACATCCGGGGCGCCACCCGCCTCGGTCGGCTTGGCGATGTGCAACTGGCCTTCCGTCACATATGCCTGCGCGCCCGCCTCCTCGGCCAGCGCGCGGATGAACTCCCAGTCGCTGATGTTCGGCTGCGCCACGTGTTCCAGCACCGGGCCCGCGACATCCATCTTTCCCGGGCGCAGCCCGGCCCGCCGGGCGACGCTGGTGCAGATGTCGGACAGCGTCATGTTCTGGTAGCTCGCGACCCGGCGGCCCCGGAAGAGGCGGTGCGACTCGTCCAGGCCACGGACCACGGTGAAGGTGCCGGTGTCGTCGATCTCCACCTCCAGCGCGGTGACGTTTCCCGACAGCAGCGGGCGCGGCGACGGACCGCCGCCCGCGCCGGCCAGCAGCCGTACCTCGGTGCCGATGGTCAGCCCCGCCTGCTCGAGCAGCACCCGGCTGGGGTCGCGGAAGCGGAGCACGAACAGATCGGGCAGGGTGCGGCTGTCGTCCACGTACCCCTCGACGAGGGTGTTGGCGAGGGCGGGCGGGAGTGGACGGCCGCCGAACTCCACGACCAGGGACTTCGCCACACTCTGATTGACCATGCCGACCTCACCGTCGCCTGTCGTGGCCGGCGCTCCGGCCCTGCTCCTGGGCGGTGGCTTCAAGACGCTCCAGCTCATCGAGGGCGGGAAGCAGCAGCTCACGGCCGTTGGCCAGGCGCATCGGATCGTCGATCCCGTTCGCCTCCGCGATCACCCGCCAGGCGGCCGGATCGCCGTACTCCCGCCAGGCCAGCAGCGGCAGCGTGTCACCGGCGCGCACCCGGTGAACACGGCGGGCGTGCAGGGCGCCCGACGTCGGGTTCTGGCCCGGGGTGTCCCCGGTGATCTCCTCCATCGTCACCTGGCACACCGCCCGGATCGGCACACCGGAGGTGGTGAACAGGGTGTACTTCGCCTGCACTTGGCTCACATAGCCGGGAAACCCGGTCAGCCCGCCCCAGTGGAACACCACCCACGGTGGCGAGGAGCGCTGCTGCTGCCGGGTCTCATTGGTCGGTACGCAGCAGGTGAACAACTGCTCCACGGAGGTCACGACGCTGGTGTCCTGGGTGTCGCTCGCGTCGAAGAACATCTCGACCGTCAGCTTGCTGGGCTGCGGCCCCTGGTACTCCGGCGGCCCGGCGCTCTTCGCGCCCTTGGCGGGAGTGCGTTTCCACGCCGCGGCCTTGGTCAGGCTCAGCTCTTTGGGGTTGAACTGGAAGTCGATACGTCCGCAGGGGCCGCCCGGGGTCAGCCCGCCGCCGGGTGGCGGGGTGCGCAACTCCAGATACGCGTGCTCCAGCTTGGGCCGAGTCCCGCCGCCCCCTTTGGCCCCTTTGGCCCCTTTGGCTGCGGCGGCCCCGCCCGCCGCGCTGAATGCCACGGGTGAACTCATGACTCCGGCTCCATGACATAGCCGTGGTGCGCGATCTCAATGGTCTCGATCGCCACCTTGGGGGACTCCGGGTTGAACGAGGGCCCGGTCCAGCGCACCGGCACGACCTCCAGCAGCCCCCATTGGGCCACCTTGCGGCCGTCGCCCGTACGCGCCTCGATATGCGCGGTCCTGCGGCGGATGCCGGTGGTCATGCTCGCGAACCACTTGGCCACCTTCTCGGTGTCGCGGGTCAGCGGCCGGGACAGCTTGATGTTGGGGTATTTGAGGCGGGTCGGCAGCTGCCAGAGGTGGGTGTTGTTGCCGCCCTCCTCGCGCTGTTCCAGCACCACTTCACAGCCCAGGCCCTCGCAGGTGTTGAACGAGCCGAGCTCGATACCGTCGACAGTGACGACGAAGCAGACGCTGACCGCCGGGTCATCGGTAACGGCCACGCCGTCTCCCTTCTCTCCGCACTTGTCAGTGCCTGGTGTTGATCAGAAAACCGGCTCGCTCGCGCTCCAGCCGCAGCTCCGCCTTGAGCAGTCGGCTCAGCGGCGCGTACAGCGCCCGGACCAGCTCGTCGTCCACCTTCGGCGGCCCGCCTTTGCCCTCGCTGGTGGTGGGAGGTGGGGGAGCGGCGGCTTCGGATTCTTCCGGCGGCTCGGGGGTGGGTTCGGGCTCGGGCTCGGGGGGTGGAGGGTCGGTGTTCTCGGAGTCGCGCTGGACGGGCGGAGGGAGTGAGAAAACGGCAGGGGTGGCGGCGCCCGCAACCGTCGGTGGCGGCGCCGGCGACGGTGGCGCGGAGGGCCTTGGCGACGGGGGCCGGAACACCACCGACCCATCGGCCATTCGCTGCGCCACACCCGCGGCAATGGCCACCGCCCCGGCGTCGACCAGCCGCGGCCCAGCTGGGGATGGCGTGACACCTGGTACGGAGCGGGAGACCGACGGGGAGGGGGACAAGGGCGGGGGCGCGGCTGCCGAAGCGATGGACCGCTGAGCCGAGGGCGCTGGCTCGGACCAACGCACCGGCACGACCAGGGGCTCAGCGGCAGGGGACGGGGAAACCCCCGACGGGCCATCGGCCGGGCCGTCCGCCGAGGGCGGCCGTACCCCCGAGAACAGGGGCACCGACCGCTGCGCGACCAGAGGCACCACCGGCCCCGCGGCTGGTGCGGGTGGCACCCTCGCCGCCGGAGTCCCGTCCGCCGAGGCCCGCTGGATCGGGACCGGCGGCCGATCCGCGACGGAGGGCGAGGGCGAGGGCGAGGGCGTGGAGGCGGGTACGGCGGCGGGCGCAGGCTCAGCCGAAGCCCGGGGTTGGGGATGGGGCTGGTGCGCGGCGGGTATCGGCGCGGGTGGCGTGGGCGGCACCGGCCCGCTGTCGGCAGTGTCGGCAGTGTCGGCCGTAAGGACTTCTAGCGGATCGTCGCCGAGCAGCGGCCTGGACACCTCGGCCTGCTCCGCCTCCGCCGCACCGCCGCCGGGGTCGTCCAGCGGTACGGCGCTGGTGCTCGCGGCGGGTGTGCGCTGCGCGGTGGGCGGCAGCCCGGCCAGCGGTTCGCCGAGACCGACGGTGTGCGGCCGGGGCGGCGTGGGCGCCGCGGAACGCCGCTGGACGGCGGGCGGAGTGGTGTCCGTATCCGGGACGGCCCGCTGCGTGGACGCGACGGGCAGCGCGGGCAGCTGACGAATCCGCATGGCCGGAGGCCGAGCGGAGATCAGCGGCTCCACGACATCCGAGCCCGCGACCCGCTGCAAGGCCACGGCAGGGGTTCCGGACGGCCGCGCGTCGCCGCCACCGCCGCCGCCGCTCCGGGGCAGGCCGAACACTCGACTCACCGTCGGCGTATCAGGCGCGCCAACCGTACTCCCCACATCCGGGGCCTGTGGCACACCCGGCGTGGCGAGCCCATGTCCCAGGCCGGACGGCGCCTCGGGGCTGACCAGGTGGCCGAGCGGGGTCAGGAAGGACGAGTCCCGCCAGGTGTCCAGGGAGCCGCGGAATCCGTTCGGGTCGGTGACCAACTCCGGTTCGGCCACCGTACGCTGCAGGGGAGGCAACTCCAGCCACCCAGGCACCGCGGGCGTGGCCGGCGTATCAGCTATGGCCGGCGTGGCCGACGCGGCCGGACCCTGCTGGGGACCACCGCGCCGAAGCCCACTCCACCAGGACAGCAATCCCATCCGCCCTCACCGCTCACTCAGCCGGGCGATGTGATGGACGTACCGCAGCCGCTCGGGGTGTTCGAGGTCGAGGATCTGGTCCAGGGGCCAGTGGAAGTGGTAGGCGAGGTACGCGACTTCCTCGTAGATCCGGTCGGTCGCGTACGTCACGATTCCCCCAGGCGACCACCGCCGGACAGGTCCACCGCGAAGTTCTCGTGGCAGGAGGGGCAGGTGACCGCGGCGCGGGTGTGTCCCTCGGCGTTGATCCTGCGGTAGAAGTCCTGGAGGAAGGCGAGATCGGAGGCGAACAGGTCCTCCACGACGCCCGGGTGGATATCGTCGATCGTGCCCAGGCGTGTGATCACGCGAGAGATGAGCACGACGGACAGATACGCGGAGTTCTCCCGGACCCGGTCGTCCCGCAGCGGAATCAGCTCGTCGCGGGCGGTCGCCAGCCGCATCACCCCGCTGCGGTGCACGGTCCCGGACTCGTCCACGTATCCGCGTGGCAGCTCGAAGGCGAACTCGGTGCGTAGCGTTTCACGGCCTTCATCTCGGTCCGTACCGGAGCCGGAGCCGGGCGGCAGCCCGGAGCCCTCCTCCTGCCGCGCGGACGGGGGGAACGCGCGCCGCATCAGTCGACTTCCACACTCTCGTAGGTGATCGACAGTTTTTCGGTGAGCACGGAGGTGTCCCCGGCCTTGAGCGTGCTGATCTCCAGCGACTTGGGCCAGGCGTTGATGAGCTTGTAGCGCTTGATCGGCATGCCCTCGTAGTCGTAGACGATGATCGAGCCATTGCGGCGGGCGCTGACCATCTTCCCGAACCGGGAATCCTTGATCCACTGCTCGAAGCTGTTGTCCTCGGTCAGCCCGCGTGTGACGGTGACCTCACCGGCCTTGGGCCGGCCCGGAAGCTTTTTGATCGCGTATTTTCCGTCCGCGGTGTTCTGCTTCAGCTCGATGACGTCCTGCTCCATCTTCAGACCACTGACCTCGGTGATCTGCCGGATGAGAACGCTGTCGAATTCCAATCCGAAGGAATGGCCTACGGAACTGTCAAATTCGGCGAGCGGCATACGACCTCCTCAATTCAGTAATTCAGTCGTGATCACTCGTCGACCCCGCCGGTCCCGGCGGAGAGCTGGGCGAGCCGGAACACCACGAACTCCGCGGGCTTGACCGGGGCCACTCCCACCTCACAGATGACCTGGCCCGCGTCGATGCTCTCCGGCGGGTTGGTCTCGCGGTCACACTTCACATAGAAGGCCTCGTCCGGAGTCACCCCGAACAGCGCCCCCTTGCGCCACTCATTGACCAGGAACGCGGAGATCGTGCGCCGGACACGGGCCCACAGGGCATCGTCGTTCGGCTCGAACACCACCCACTGGGTCCCGGCGAGAATCGACTCCTCGAGGTAGTTGAAGAGCCGCCGCACATTGAGATAGCGCCAGGCCGGATCGTCGGCCAGGGTCCGCGCCCCCCACACCCGGATGCCACGGCCGGGGAAGGCCCGGATGCAGTTCAGGCCGATCGGGTTGAGCAGGTCGTGCTCGCCCTTGGTGATCTGGGTCTGCAGCGCGACCGCCCCGCGCAGCACTTCGTTCGCCGGAGCCTTGTGCACCCCGCGTGAATCGTCGTTACGCGCCCACACGCCGGCGACATGCCCGCTCGGCGGTACGAAAGCATCGCGGCCGACGGCCGGGTCGAAGACTTTGATCCACGGGTAGTACATGGTGGCGTACTTGGAGGCGAAGCCGGTCGTCTCCTCCCGCCAGGTCTTGATCTGCCGCGGGCTCAGACCGGGCGGGGGATCGAGGATCGCGATCCGGTCGCCCATCGCCTCGCAGTGTGTGATCAGCCCGCGCTGCACCGAGATCACCGACTCCAGGTCCAGCAGCCCGCGCTGATAGGCGCTCATCAGATCCGGCGCGGCCACCATCGTGATCTCTTCGACCGCCTCCAGACCGCCGAACCCGGTGCGCTGGTCGGGGTCGCCGACGTACGAGTCCGCCGACAGCGCATCGGGCACGGCCGCCCCCGGACCGGAGCCTTGCGCCCCCGCCAGGGTCACCGACTGCGCCTCGGGCCGCGCGGGCGCGGCGCCCTTGCCGGGCTCCTCCAGCCTGATCAGCTGGGACCGCGCCCTGACCTGTGTGGCCACATTCTCCTTGCTGCGCTTGGTGGTCACGTTCGGATAGGTCTCCACGACCGCCCCGTCCCGCTTGACCACCAGCGTGAAGACATCCTGCGGCGGGTCCTCCCCCTCGGGGTCGGCCACCTCGACGGTGATCTCCCCGGTGACGCCGGGGAGGGCCCGTACGGTGTAGGGCCCGAGTTGGGCGGTGGCCTCGGCGCCGATCTCCTTAGGCGCGCCCGTACCCGCTTCCCCCTGGTCTGCCTGACCGGCAACGCCGATGCGTACGACGTAGCAGATGCCGCCGCCGTTGGCGAAGAAGCCGTAGACGGAGGAGGCGAGATAGGTCCCCTCGACGAAGTCGCCGAAAACGCTCGTGAACTGGGTCCAGTTGGTGATGAGCGTGGGCTCGTTGAACGGACCTTTCTGTGCGAACCCGATGAAGGCGGCGACGGAAGTGCCGACCCCTTCTATGGGCCGCGACCCGGATTCCACCTCTTCGACGTAGACACCCGGGGACAGGTATGACGGCAT

Protein sequences of DBSCAN-SWA_6

>NC_016582|10633537:10646120|10640471_10641299_-|WP_055414061.1|DBSCAN-SWA
MSSPVAFSAAGGAAAAKGAKGAKGGGGTRPKLEHAYLELRTPPPGGGLTPGGPCGRIDFQFNPKELSLTKAAAWKRTPAKGAKSAGPPEYQGPQPSKLTVEMFFDASDTQDTSVVTSVEQLFTCCVPTNETRQQQRSSPPWVVFHWGGLTGFPGYVSQVQAKYTLFTTSGVPIRAVCQVTMEEITGDTPGQNPTSGALHARRVHRVRAGDTLPLLAWREYGDPAAWRVIAEANGIDDPMRLANGRELLLPALDELERLEATAQEQGRSAGHDRRR
>NC_016582|10633537:10646120|10643474_10643618_-|WP_014181555.1|DBSCAN-SWA
MTYATDRIYEEVAYLAYHFHWPLDQILDLEHPERLRYVHHIARLSER
>NC_016582|10633537:10646120|10638523_10640464_-|WP_014181551.1|DBSCAN-SWA
MVNQSVAKSLVVEFGGRPLPPALANTLVEGYVDDSRTLPDLFVLRFRDPSRVLLEQAGLTIGTEVRLLAGAGGGPSPRPLLSGNVTALEVEIDDTGTFTVVRGLDESHRLFRGRRVASYQNMTLSDICTSVARRAGLRPGKMDVAGPVLEHVAQPNISDWEFIRALAEEAGAQAYVTEGQLHIAKPTEAGGAPDVSARAAREPLVLEMGDNLLRCRAGVSAAEQVSAVEVRGWDVRAKEPLVGRADAGKAATLDLGLTAAEVAQPFGEASFVVSDAPYGSQAQVDQAAKALAARIAGSFAELEAVIRGNPEVRAGGAVTLAGVGKPFEGRYTVTSSRHVFDPVRGYETWVTVSGQQERSLFGLTGGGSGGGTDTGARCSGLANGTVTDTKDPEGLGRVKVRFPWLSDEYASDWARTAQAGGTAGGEAFIPEVGDEVLVGFEQGHLDRPYVLAGLYNGKDKPGQGGQGGPGRPQGLGPGQAQGQGQGQGGGQDAEAVDPTSGAVNKRAFGSRGGNKLELLDAANGPQGVRLVTGDGKLKINLDRQGTTIVVHSDGKVEIEAKEQVSIKAGSGVTLEAGKGPLELGGDSVKLTARNGVAVDGGSGQVKLSTGGTVEVQGAQVAVGSTNRTEIKGGNSLSVNAPLVRIN
>NC_016582|10633537:10646120|10635175_10635736_-|WP_014181547.1|tail|DBSCAN-SWA
MRGPLPGLPTAHPLLHQLPAVYHGEEFLERFLSALDEVLAPVLLTLDNLPAHLHPRTAPEDLLAWLAQWVAVEVDQDRPVNQRRAVVATAVTRHRQRGTRQGLAAAVRVETGIEPEISESGGTSWSSEPGAALPGSARPWVTVRLRVPDPEQFDRTRVEKLVAAEVPAHVPYRVEIVAATEGAGPS
>NC_016582|10633537:10646120|10643614_10644085_-|WP_014181556.1|DBSCAN-SWA
MRRAFPPSARQEEGSGLPPGSGSGTDRDEGRETLRTEFAFELPRGYVDESGTVHRSGVMRLATARDELIPLRDDRVRENSAYLSVVLISRVITRLGTIDDIHPGVVEDLFASDLAFLQDFYRRINAEGHTRAAVTCPSCHENFAVDLSGGGRLGES
>NC_016582|10633537:10646120|10635736_10637740_-|WP_014181548.1|plate|DBSCAN-SWA
MTLPTPNLDDRRFQSLVDEAKRLVQQRCPEWTDHNVSDPGVTLIEAFATMVDQLVYRLNRVPDKNYLAFLDLIGVRLYPPTAAHTDATFWLSAPQPEPVRIRAGTEIATVRTETEEAVVFTTSRDLSVVPCALTHLATWPASGNAADRSEELALGRDVPCFGPTPVPGDSLYIGLSDPVPGCAVVLRLDCRVDGVGVDPRRPPLLWEAWDGNAWVACEVEKDDTGGFNKAGEVILHVPATHTGSVLVRQSAGWLRCRLLQAAPDQPTYVASPTVRQAGAFTIGGTVEAEHSEKVVEEVLGLSEGVPGQSFQVARPPVVAGEEPFVVEVAEGPGWLEWTRVDSFAHSTPYDRHITVDPNSGQVDFGPAVREADGTLRLFGAVPPKGCPVRVRAYRTGGGRRGNVSRGALRVLRSSLPYVARVANRRPALGGVDGETVEDARVRGPMTLRTLHRAVVPHDYEQLAREFAPDAARVACVPAGEYRAEGGTDGARTDGAQTGGAQTGGVRLLVVPTGRDDEQGRIRFEDLIPPPATLARLADHLEERRPIGAQLSVEPPYYQGVTVVATVSPSRGTAADRLRDKALTALYGYFNPLTGGPDGQGWPFGRPVHSGEVFAVLQQVPGVDLVEDVRLFPADPVTGQRGEATNKIELDGHALVFSYEHQLRVREA
>NC_016582|10633537:10646120|10634180_10634711_-|WP_043492487.1|DBSCAN-SWA
MPVVLLVLAAAAWFGRGQLSELFTFTQDRTSDPKPLHADQFRGSSQAPGHTAHAAFDGYNNKYWAPATGGPADGQYLEADFDQPVRLLKLLITSGSSAKEAEFLTQARPSELTVTLVSSEGKRSTKTLKLNDKPGQQTFDVPGTEVTRVRLTVGGAYGVRSDRRVAIAEVEFFGRR
>NC_016582|10633537:10646120|10644084_10644528_-|WP_014181557.1|tail|DBSCAN-SWA
MPLAEFDSSVGHSFGLEFDSVLIRQITEVSGLKMEQDVIELKQNTADGKYAIKKLPGRPKAGEVTVTRGLTEDNSFEQWIKDSRFGKMVSARRNGSIIVYDYEGMPIKRYKLINAWPKSLEISTLKAGDTSVLTEKLSITYESVEVD
>NC_016582|10633537:10646120|10637756_10638164_-|WP_014181549.1|DBSCAN-SWA
MGQQFIGAGWAFPPRTDATGSIALVRDERELEESIRLILATSPGERPMRPEFGCALGDYVFAPADAGTAGQLAYEVRLALERWEPRIEVAEVAVRFDEADQGVLYIDISYAVRGANDPRNLVFPFYVIPHTEERA
>NC_016582|10633537:10646120|10641758_10643468_-|WP_086013699.1|DBSCAN-SWA
MGLLSWWSGLRRGGPQQGPAASATPAIADTPATPAVPGWLELPPLQRTVAEPELVTDPNGFRGSLDTWRDSSFLTPLGHLVSPEAPSGLGHGLATPGVPQAPDVGSTVGAPDTPTVSRVFGLPRSGGGGGGDARPSGTPAVALQRVAGSDVVEPLISARPPAMRIRQLPALPVASTQRAVPDTDTTPPAVQRRSAAPTPPRPHTVGLGEPLAGLPPTAQRTPAASTSAVPLDDPGGGAAEAEQAEVSRPLLGDDPLEVLTADTADTADSGPVPPTPPAPIPAAHQPHPQPRASAEPAPAAVPASTPSPSPSPSVADRPPVPIQRASADGTPAARVPPAPAAGPVVPLVAQRSVPLFSGVRPPSADGPADGPSGVSPSPAAEPLVVPVRWSEPAPSAQRSIASAAAPPPLSPSPSVSRSVPGVTPSPAGPRLVDAGAVAIAAGVAQRMADGSVVFRPPSPRPSAPPSPAPPPTVAGAATPAVFSLPPPVQRDSENTDPPPPEPEPEPTPEPPEESEAAAPPPPTTSEGKGGPPKVDDELVRALYAPLSRLLKAELRLERERAGFLINTRH
>NC_016582|10633537:10646120|10633537_10634095_+|WP_055414060.1|integrase|DBSCAN-SWA
MAGEPAGEPAGDRYPRPVVSDAEAEWVWRLLSVQAMEQGTRPETVRLAVVVGLARATGARYGDLLRCTTDALDLDAGSVAVEHGKHRVPRRHGLDPGTVMVLRRWLRVRQELCVELEGTVPRALLLTVHHTHDNGVTVAAGLPITRQGLVLSWRRFVHRTNATYAARRPPLPTRFEQLRRVWSTG
>NC_016582|10633537:10646120|10641295_10641733_-|WP_014181553.1|tail|DBSCAN-SWA
MAVTDDPAVSVCFVVTVDGIELGSFNTCEGLGCEVVLEQREEGGNNTHLWQLPTRLKYPNIKLSRPLTRDTEKVAKWFASMTTGIRRRTAHIEARTGDGRKVAQWGLLEVVPVRWTGPSFNPESPKVAIETIEIAHHGYVMEPES
>NC_016582|10633537:10646120|10638170_10638446_-|WP_014181550.1|DBSCAN-SWA
MPAAARVGDPTGHPGVVGPPGEPTVLIGGRPAATVGTPHQCSAPAAHPPSQIAPPGSATVLIGGQPAARVGDTAGCGSPITAGCPSVQIGG
>NC_016582|10633537:10646120|10644560_10646120_-|WP_014181558.1|tail|DBSCAN-SWA
MPSYLSPGVYVEEVESGSRPIEGVGTSVAAFIGFAQKGPFNEPTLITNWTQFTSVFGDFVEGTYLASSVYGFFANGGGICYVVRIGVAGQADQGEAGTGAPKEIGAEATAQLGPYTVRALPGVTGEITVEVADPEGEDPPQDVFTLVVKRDGAVVETYPNVTTKRSKENVATQVRARSQLIRLEEPGKGAAPARPEAQSVTLAGAQGSGPGAAVPDALSADSYVGDPDQRTGFGGLEAVEEITMVAAPDLMSAYQRGLLDLESVISVQRGLITHCEAMGDRIAILDPPPGLSPRQIKTWREETTGFASKYATMYYPWIKVFDPAVGRDAFVPPSGHVAGVWARNDDSRGVHKAPANEVLRGAVALQTQITKGEHDLLNPIGLNCIRAFPGRGIRVWGARTLADDPAWRYLNVRRLFNYLEESILAGTQWVVFEPNDDALWARVRRTISAFLVNEWRKGALFGVTPDEAFYVKCDRETNPPESIDAGQVICEVGVAPVKPAEFVVFRLAQLSAGTGGVDE

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
10629315:10629329	attL	NA	NA	NA	NA
WP_055414060.1|10633537_10634095_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_043492487.1|10634180_10634711_-	discoidin domain-containing protein	NA	NA	NA	NA
WP_014181547.1|10635175_10635736_-|tail	tail protein	NA	NA	NA	NA
WP_014181548.1|10635736_10637740_-|plate	putative baseplate assembly protein	NA	NA	NA	NA
10635875:10635889	attR	NA	NA	NA	NA
WP_014181549.1|10637756_10638164_-	GPW/gp25 family protein	NA	NA	NA	NA
WP_014181550.1|10638170_10638446_-	PAAR domain-containing protein	NA	NA	NA	NA
WP_014181551.1|10638523_10640464_-	VgrG-related protein	NA	NA	NA	NA
WP_055414061.1|10640471_10641299_-	hypothetical protein	NA	NA	NA	NA
WP_014181553.1|10641295_10641733_-|tail	phage tail protein	NA	NA	NA	NA
WP_086013699.1|10641758_10643468_-	hypothetical protein	NA	NA	NA	NA
WP_014181555.1|10643474_10643618_-	hypothetical protein	NA	NA	NA	NA
WP_014181556.1|10643614_10644085_-	hypothetical protein	NA	NA	NA	NA
WP_014181557.1|10644084_10644528_-|tail	phage tail protein	NA	NA	NA	NA
WP_014181558.1|10644560_10646120_-|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	2.6e-69	33.9

Sequences of DBSCAN-SWA_7

Nucleotide sequences of DBSCAN-SWA_7

>NC_016582|11680346:11733773|DBSCAN-SWA
ATCAGGCAGCATGGTGATATTCATGGAGGAGTCCGCTGAGGCGGTCTCGTCGTCGTATGTCGAGGTGGGTTGACTTGTCCGGATCGTGGATTGGTGCGGGCAGTGGGTGTAGCGGTCGGGTGTTCGCGATGCCTTGGTGCGGGCGGTGTTCGTTGTAGAACGGCTCGAACTCTTGTAAGGCGTGGAGGAGGTGGCGCTGGTTCCCGATCAAGGTTCGGTCCAGGAACTCGCGTCTGCAGGTCTGTATCATCGAACAATGTAGGGAACTTCTCATCGCTGTCCCCAATCATGAACCGCAACCGGCAGCTGCCTGCGTCCTCGGGGGCCATGACCAGGTTCTTTGCCGCTTGCGCCACCCAGGATGCGAAGAATCTGGTCATGGACCTTGAGGACGTCGGCTGCCGGGCACGATTCATCATCAGAGACAGAGACGGGGAAGTTCCCCGCCCTGTTCGACGCTGTCCTCAAGGGCACGGGGATCGAGGTCGTCCTTACCGGCAATTCGAGGAGTTCTACAACTCCCATCGACCGCACCAGGGCATCGCGAACGCCCGACCGCTACACCCACTGCCCACACCAATCGACGATCCGAACAAGCTAAGCCACCTCAACACACGACGCCACGACCGCCTTGGCGGCATCCTCCCCGAATACAGACATGCCGCGTGACCTGCACGGACGAGGTATTCGGCAAGCGTAGTGCCGAACGTTCCCGCTCAACCGCCCTGCCCGGGTGAGTGGGGGGGACTGGCGTCTTCGTAACCGCCACGCGACCGAGCAGGGCCACCCTGATGATCAAGGGCCACCGGAGCGGAACCCACGTGAACAAGGCTCCGGGTGTGCGAACACGCCCGATCGAGCCGTACGGACCATGAGCTCTCTGACCCCGGTGGGCGGGCGGATCAGCGCAGTCCGGCGAAGAGGTCGTTCTCGGGCACGGCCGCGCCGGTGGTGTCCTGGACACGTACGAAGGTCTCGACGCCCATCAACTCGGTGAACCTCTCCTGGCCCATCCTGAGGAAGAAGATGTTCTCGCCCTGGCTGGCGTGCGCGGCCAGCGCATCGAACTTCTGGCCGCCGAACGCGGTGGTATCCACCCAGGTGGTGATCTCCTCGTCGGGCAGTCCGATCTCGGCCATCGCGGCGGCCTCAGCGGGATCCGGCTCCTGCCCGTCCGCACCGAACTCGCGTATGACCTCCCCGAACCGCTGCATCATCGAGCGGGGCGCCGTCGTCCAGTACACCTTCGGTGTCAGCGCGGTCATCGCCAGCGCCGCCATCGTGATGCGGTTGGCCTGGATGTGGTCCGGGTGGCCATAGAAGCCGTTCTCGTCGTACGTGACGACCACATCGGGCTGGTAGCGCCGCAAGAGTTCCGCGAGTCGGGCAGCGCCCTCCTCCACGGGTGTCTGCCAGAAGGAGCCTGGGGCGTCATTGGTCGGCCACCCCATCATCCCGGAGTCGGCGTAGTCCAGCATCTCCAGATGACTGATCTTCAGGACTTCACAGCTTGCCTCGAGTTCTTGACGCCGCATCAAGGCGACGGCCGCCCCATCGTGTCCGGGATCGCCCGGCTTGACACCCCCCGGTCCGTCACCGCAACCACCGTCGGTGCACGTCACGAGGACCGTGCGAATGCCCTCCGCCGCGTACCGCGCGAGGACACCTCCTGTTCCAGTGGCCTCATCGTCGGGGTGGGCGTGTACCGCCATAAGCGTCAAGGGCAAGTCATTCATGAAACGGTCCTCCTGTGTGAAAAAGCATTGGTCCGAGTCCGTGGCGGGCGTATGAGCGGTCTCCCTTCAATATCGGATGTCGGATGACCGGGCGTACCGCGGACCCGAGGGCCCCGGATCACGTCGGCTGTTGGTCTCTGTGTTCCCCGCCCGCGCGGCGCCGCTCTCTTGGCAGTGCAACAGTGGCGGCCGGACCGGCTGTTCCCGCCGCACACCGGAACTGTGCCACTCCCACGAGAACGAAGAGGCGGCCAGGGTGGCGGCCAGGCCCGGCAGGGTGAGGCGTGCGATGGCGTCACGAAGATCACCCCCGCCCGCGCGCAGGCCCTGAAGGACGCCGGCTACAAGTACATCGGCCGCCACCTGTACTACAGCGTGGAGCAGGGCGCCGCGGACTGTTTGCACGCCGCGGCCAAGGCGGAGGAGCACGGGTACAAACCGGGCTCACGCATCTATTTCGCGGTTGACTACGACGCGGTGAACGACAAGGTCACCTCGTACATCCTGCCGTACTTCCGGAGTATCAAGGAGCAGATGGGCCGGTTGGGCAGCCCTTATAAGATCGGGGTCTACGGCCCTCGCAACGCGTGCTCCCGGATCTCCGAGGAAGGCTATGCGGACACCCGTTTCGTGTCCGACATGTCGTCCGGCTTCTCCGGCAACCTCGGCTACGCGATGCCGGAAAACTGGGCCTTCGGCCAGATCGTCACCAAGTGGGTCGGCTCCGGTAATGGTCGGATCGAGATCGACAACAACATCGCCTCTGGACGTGATCAGCCACCATTTTCGCCGGGCACCGGTGCCTCCATGGTGGAGTCACGCACTCCCCCACCGGAGGTGAACGCAGTGACCTCTCAGTCTCCTGAACGCGGCCGGGTGTTCCGGCGTTGCGGTTGCCGTCGCCCGGACGGCCGGCAGTTCGGTGCCGGCTGCCCCCGACTCCAGGATGGTTCGAGGCACGGGTCCTGAGCTTTTGCCGTCGACCTGCCCTCGGCCGACGGCAAGCGCCATCCCCTGTGCCGTGGCGGATTTGCCACGCGGAAGGCCGCCGGGACAGCGCTCGAGCGTGCCATGGAGTCCGAGCGGACCGGCCTGGACTGCAGCGAGGATCTCGCCCTTGCCACGTATCACGCCGAGTGGCTCCGTCTCTGGGAGAAGACGCTCAAGCCCACGACGTTCGCCCACTACCGCGACCACGTGCACACAGACCTCATCCCCTCCTTCGGCCGACTGCCCCTGACCGATCTGCGGGCCCGGAACATCACCGCCTGGAGTGAGGCCGAACTCGCCCGCGGACGCGGGCGCACCGCCGTCTACCGGATCGGCGCCACCTTCTCCAGCGCACTCAGCCACGCCGTGCGCACACGCGACCAGGTTGGGATCATCGAACGCTGCGGACACCGCACGTGGCGGCATGGAAGAATGCATCCCGGAGATGCACCTCCGAACTGGTCGAGTAGAAGCCTAGAGAACTCCTATTTTCCCAGGTCAGAGTGCATCTCCGCTTTCATGTCCGGACACTGGACGAACCGACACCCGGTGGATCGAGGCTTAGGGTTAATCGACGCAGGCACCGCGCAATGGGTAAGTAGACCGAATCAAGGGCCTCGAGAGACCTCAGCGTGCACTCGAATCGCGGGCGACTGGACGGCGTCTGCAGTACTCATCTGCCGCATGGCGTGGAGTTGCCGGGCCTGATCCTCTAAGCGGGCTCTGCCGCGAGCAACTCCTGGCATCGTGTGTCCCATGGGTGAACTGATTGACTGAAGCTTCCACCGGAAGCGCGCTCCCCGATCGGTAATCGGTGGGAAGCTACTCGCGGGGTCCTGGTCAGCCTTGCTGCGATTCTCCCGAGCACTCACTGTCGCCAGGGACCTCGCATCCCTCAGGTCATTGGCGTAGTTCTGGCGTTCACGAGGTGGTCAATGCCCAGGACGCGGGCGTTTGAGACATCGGTGGCGTCGTAGTACGAGTGCCACACGCCGCCGGAGATCGCGCAGTGGCCGCTGACCGTTGGCGGCTCGATTGGCGGTCGTGGAACCTGACGCCCGTGGGTGTCGTCCGCAACGGTCCGGTGCCGCGCACCAGGTGTCATCGCTGGCTGTGTGACTCCCTGTCGGCGGGCGCCCGCCGAGATCGAGCCCTCTTGGGCCACGGCTACGAAAGATGCGAACAGGGCGAGGCCGAACCATTATTCGACATCATGTGGATCATCTGCCCATCATGGCAGTGGACTCGACCGGAGCCGTCCTCCGAAGGGGCATATTTGCGTGACCATGACAGGCCCAGGTGCAGCGCCGAGCGCAAGGCGCGTCGAGCCGTGCTCGGCTCTTTCGTGGGGACTTCCGTCGAGTGGGCTTCGAGGGCATCGACTAGCGCCTTGGAACCGCCTGCATCGCCACCCGCTGGCAAGCGTGGAGCGGACCGGAGACTGCCGGACGTCTCCGGACTCCCGTCCTCCGCTCCGACGCCTCGTTCTCAGAGACCCCCGCATACGAATCGAGGAGTACACCGTGAGCAAGCCCGGACAGACCGTCGAGATCCCTCACCTCGGGGGATCGACCGTCGGGTACACCTTCGGCAAGCCGTACGACCCCGCACTCCCAACGCTGGTCCTGATCAACTCGTACACCACCTCGGCCGAGTTGTACCGGCCGCAGTTCGCCGACCCGGAGCTCGGGTCCGCGGCCAACCTGCTGGCCCTCGAACCCTACGGGCACGGCCGCACGAGGGCCGCGTACCAGCACTTCACCTACTGGGACAGCGCGGTCGCGAACCTGCAGGCCCTCGAGGCCCTCGGGATCGACGAGGCCTTCGTACTGGGAACCTCGCAGGGCGGCTGGGTGGCGGTCCGCATGGCGCTGCTCGCCCCGGACGTCGTGAAGGGCCTCATCCCGCTCGGCACGTCGATGGACTTCGAGAGCCCGCGCAGCCGCGACCTGGGGTGCTGGGACGGGATAGGGTCCAACACACCGCTCGTCGACGCCCTCGCCGACCCGGTCGGCGAGGACTGGGTCGTGCCGGACGAGGTCGTAGACGCCGTCTTCGCCGCGGCCCTGGGCGGCGTCTCAGCCGAGGAACGCGAGTTCTGGCTCACCGCCTACCGTGCAAACTACAGCGGTGACGCCGGACGCCACCGTCTGCGCCTCAGCACGGTGAACCTGCGGGACCGCGACGGGCTCCACGGCAGACTCGACGAGGTCCGCTGCCCCGTCCTGTGGCTGCACGGTACCGCGGACCAGGTGTACTCCGTGCCGAACGCCCAGGAGGAGATCCAGATGTTCACCAGCTCCCCCGAGGCGCGCCTGGAGATCATTGAGGGCGGGCAGCACTTCCTGAGCGCCTCGCATCCCGCGGAGGTCGGCTCCGCAGCGATCGAGTTCCTGAAGCGCTGGGCCCGAGCCTGAAGCCACCTGTGCGTCGGCCGGTTGATCTTCTGCGTGATTGTTGATCGATCCGGGCGGGGTGGACGGGGAGGTGCCCTGGACCGGGCCTCCGGGCACCTCTGAGTGACGGCGGTCTCGGCTCCGAAGAAGGCCGACGCCGCCCGTTCCTGAGCAGCCGCGCGGGCACAGCCCGCCGGGCCTGCTCTGCGGCGGCTTGCTCATGCCGCCACACGAAGTCCTCACCTATCGCCGCCGTCGACCGGGCACTATCACATGCATGACACACGCCTCGTGTTTCGCACTTTTCGCGATCGAGTCGTGTGTGAACTGGTGTGAGGTGTGTGGCTCGTTGTGGTGAGCGGGTTCGGTCCCGGATTGAGGATGGGGTGAATGCAGAAGCATCGACGGTGTCTGATTCACCCTGAGTTGAGAGTGATCCGCCGATGCTTCCGGACGAGACACTACCGTCACTTGCCGCTGTGCTGATGGTGTTCCGCAGGTGTTTCACCGCTCCGACGTACCGGACGTTCACCGGTCTGGTGGTCGGCCTGATCGCGCAGACGCGCTGGAGCTAACGAACACCGGGCAGCTGGTGCTGTCGCGTCGGCGGTGACGACGACGCCGTGCAGGTCGATCCGTTCCGGCAGTGGGGCGAAGGCGGGGATTTCGTTGCTCTTCGCGGCGACCTGGCGCTGAGCGATCACGGTCTGGCAGGGGTGCAGCGCGTCGCCGTCCAGGCGGGCCGGGAGCCGTCCCAGTGTGAAGGCGTCCGGCGTGGTGGAGGCCGGCCCGAGCCGTTCTCGCAGTTCGGAGTCGGTGGCGGCGGCGAAGCGGGCGATGGCGGCCAACGGCTTGGCTCCACCGAGGACGGCGAGCAGGCACAGCGCGAGCAGGGAGCCCAGGCGGTAGCGGCGGCCTCGGACCTGGTGGGGATCGGGTATCCGGCCCAACACCTCGGCCAGGCAGGCGAGCTGCGGCGGTTCCGGATCCGGGCAGATGGAGTCGGTGTCTCCGCAGTGGCGCTGCAGGACACCCGGTCAGGAAGGACGGCATGCGAACGCGACCCCTGCCCATGATCAAAGGCTTCGGCAACCTTGATCATCAGGGGTCGCGTCTCTCGTTGCCGAACCGGGCGAACCACACGCACAGGCATGTACACCGGCGACCAGCCCATCTCGCAGGCTGGGAACGCATCAGCCCTGGTGTCCTTGGGGTTGAGTTCGAGGCCGGACCAGTCCGGTTACGGCAGATACGACCGCGGCTTTGTGATCGGCGCTCCGCTGTAGTCACGGGGATCTGTGCGAACAGCGGTAGCTGCCGCCAGCCGGGACCCGGGCGCCAGGCCGGTGCAGGAGGCGGCTTGCGCGGGGCTCTCCGCCGTCCTCCGCGCCTCCGCGCCGACGGGGTCGGTCTTCTGCGGTAGTGCATCCCGACGAGGAACAGTTGGTGATGCCGGATGGCGGCGAGCCGGTCCCGCACGTCCGTCTCGTCCGCGGGATGGCCGGCGACGTTCTTCGCACTGAGGCGGGCCTGGCACCAGTACAGGCGGCAGTAGTTCCACTTCAGCGGCTGGATGCGGCGGCAGCCGGTGCGTGCGGCAGGTCCCGTACGACCGCCGGCGCCAACCCAAGCCCCCTCACCTTCAGCCCGACTGCGGATCGGTCGGATGACGTGAGAACGGTTCAGGAATCCCGAAGTTACGTCAAAAGCCGGCAGAGGACACGAAGGAGGAAGAACCCCCTGGCCACGGGGCCAGGAACTCAGCGGGGCTCAGGAGAACTCACGGGATGTCGCACAGTAGCCGGTCAGCAGGGTGAGCGGTCCGGTGTTGGTCAGGTCCAGCGACCGTTCCAGCCCGGGGAAAATGCCCGTGAGCTGGGCTCGCAAGCGGTTGACGGCGCGAGTGGCGGTCGCCCTCCGAGGGTGGCCGAAAGACGCACGTCGGCGGGTCTCAGAAGAGTGGCCAGTTGCGCAGGGCGGCGTCGGCCATCTCCTGGAGTTCGTCGCGGCCGACACCGCTCGCGGCTTGTACGGCGATGCCGTAGGCGAAGGTGGTGAGGTAGCGGGCCAGTAGCCCCGGATCGGTCTGCGGAGGCAGGTCGCCGTCGTCGACGGCACGCTGGAACCGCTCCCGGATGCAGGAGTGGCCGTTTTGGCGCCAGGCGACGAGGAGGTCACGGACTTCCTGCCCGGAGTCGCTGGTGGTCAGGGCGCTCTGGACGCCCAGGCATCCGTGGGGATGGGCCGGGCGGGTGGTGGTTCGAACGGTGCCGGCCAGGATCGCGGTGGCGACGCCGAGGGCGGTCGGCTCCTCCATGGCTCGGGCCAGGTATGCGCTCGGGCCTTCGGTGTAGCGCTCCAGGGCTTTGCGGAACAGCTTCTCCTTGTTGCCGAAGGCTGCGTACATGCTCGTGGTGGAGATGCCCATCGCGTTCGTCAGGCAGGCCGTGCTGGCCCCCTCGTAGCCATGCTTCCAGAAGACCAGCATGGCGCGCTCGAGAGCTTCGTCGGCGTCGAATCCTCGCGGTCGGCCGATCGGGCCGGTCTGTTTCGTCTCCACCCCCGCAGCCTACCGCTTCTGCAGGGATCGCTGCAGAAGTGCTAACGTTCGACTTCCGCAGCGATCGCTACGGAAATCGAAGGGGCTGCTCACATGGGACTACTTGAGGGAAAGACCGCTCTCGTCACCGGGGGCAGCACCGGAATCGGCCTGGCCAGTGCCGTGCGGCTGGCGGCCGAGGGCGCACACGTGTTCATCACCGGCCGACGCAAGACTGAACTCGACGCGGCCGTCGAAGTGATCGGTTCAGCGGCTACCGCGGTGACCGGTGACATCTCGAACCTGGCCGACCTGGACCGGCTCTACGAGACGATCCGCAGCCAGGAACGGGGCCTGGACATCCTGTTCGCCAATGCCTCCGTCGCCTCGCTCGTGCCGCTCGCGCAGGTCACCGAGGAGCACTTCGACACCCTCTTCGGCATCAACGTCCGGGGCACGCTGTTCACCGTGCAGAAGGCTCTGCCACTGCTCAACGACGGCGCTTCGGTCATCCTGAACGGCTCTACCAACGTGGACGTCGGCGATCAGGCGCTCGGCGTGTACGCAGCGACCAAGGCCGCCACCCGATCGTTCTCCCGGACCTGGGCCAACGAACTCAAGGGACGCGGCATCCGGGTCAACACCATCACGCCCGGCCCGACCGATACCCCTGCACTGTCGGGGCTCACCCCCGCCCCGGAGCGGTTCAAGCAGCAACTGGCGACGCGTGTGCCGCTGGGCCGGCTCGGGCGCCCGGCAGAGATCGCCGCTGCCGTGACCTTCCTCGCCTCCGAGCAGAGCAGCTTCATCACCGGTTCGAGCCTGTACGTCGACGGCGGCCTGAACCAGATCTGAGAGGCGTAACCACCCATGACAACAATTGGGATCATCGGCGCAGGCGAGGTCGGCAGCCAGATCGCCCGTGCGGCACTGGCAAACGGATACGAAGTCGTCATCGCCAACTCGCGGGGCCCCGAGACCCTGGAGAACCTTGTCGCTGAACTCGGCCCGTCAGCGCGCGCCGCACGCGCTACGGATGCCGCGGCAGCCGGCGACTTCGCCGTCGTGGCCGTCCCGCTCAAACTTGTCAACGACATGCCGGTGGAAGGGCTGGCAGGCAAGATCGTGCTGGATACGAACAACTACATGATCTGGCGCGACGGCCACTTCGACGTCATCGACTCGGGCGAGAAGACCGTGCTCGAACTGCGCCAGGAGCACCTCCCGACGTCCAAAGTCGTTCAGGCATTCACTCATATTCAGGCCCCCCGCATCACCACCGCCGGCCGTCCCTCTGGCACTCCCGACCGACTGGCGCTGCCGACCTCGAGCAATTTCCCGGAAGCCGTTGCACTCGTGACGCGGCTGTACGACCAGTTCGGTTTCGACACCGTGGACAACAGTCCGCTGAGCGAATCCTGGCGCACTGCTCCCGGCCAGCCGGCCTGGACCGAGCTCGCGCACCAGACCCGCGACAAGCTGACCGTCAATCTGACGAGAGCACGGCGTATCAGTCAGGCGCCCTCCTGACCGGCGGATACCCGCTTCAGCGATGGCCGGCACGGCGAGGCCGCAAAGTGCGTCGCGTCCCATCAACATCCAAGTGCAGCTCCGATTTGGAACTGCCGCACAGAAAGGCCACCTCATGTCCGACGGTGATCTGCGCGCGTTCTACCTTCGCTATATCGAGGAACTCAACGCCCACAAGTTCGACGGCATGGGCAAGTTCATCAACGACCGGACGACCCTGAACGGCGAGCCGGCCACCCGGGACGACCTCATCGCGGTGCAGAAGCAAGACGTGGACGCGGTCCCGGACCTCCACTGGGAGCTCAAGGAACTGCTCTTCGACAGTGACCGTCTAGCTGCGCGTCTGATCAACACGGGTACCCCGGTCAAGGAATGGCTCGGCGTGGCTCCCACCGGCGCCTCCTTCGAGATCGTCGAGTACGCCATCTACCAGCTCCGCGACGGGCGGTTCGTGCACATGACCGCCCTGCGCGACGCCGGCGAACTTCACCGGCAGCTGACCGGCTGATTCGGAAGAAACAGTCCGGACGCCGTCAACGGCCCACTCGGGCCACATCATTCGAGAGGACAGGCAATGACCGTCACACTGATCACCGGGGCCAACAAGGGGATCGGCTTCGAGACAGCCAAACAGCTCCTTGAGCTGGGCCACGTCGTCTACATCGGCGCGCGTGACGCCGAGCGAGGCGAGAAGGCCGCGGCAGCGCTCGGCGCACGATTCGTACAGCTCGACGTCACCGACGACGCATCGGTGAAGAGCGCGCTGGCGACGATCGACTCGGCCGAGGGCCGGCTCGACATCCTGGTGAACAACGCCGGCATCCTGGCAGACGGAGTCCTTGACGGCCCCACGGCACTCCGGGCCTTCGACACCAACGCGGTCGGAATCGTGCGCGTCACAGAGGCGGCGCTTCCCTTGCTGCGCAAGTCCTCCGCCCCGACCGTGGTCACCGTTTCGAGCAGCGCCGGGTCGTTCTGGGCCGTGACCAACCCGGACCGGCCGGAGTTCAACCTGCCGCTGGCGCTCTACTCCGCCTCCAAGTCCGCGGCCACCATGCTCACGGTCCAGTACGCCAAGTCCCAGCCGGGCATCAGGTTCAACGCGGTCGAGCCCGGCACCACCGCGACCGACCTGACCGCGGCATTCGGAATCGGAAGAACGCCGGAGGAGAGCGCCAGGGTCGTCGTGCGTCTCGCAACTCTCGACGCGGACGGCCCCACAGGAACGTTCCAGGATGAGAACGGCGAAGTGCCCTGGTAGCACACCCATGAACGATGAAACGCTCGCTCAGCGACATGAGACCGTCCGAGAGTACTTCAGGCGAGTGGACCGGGGAGACCCGGGCTTCGCCGACATCTGCACCGATGACATCGAGTTCTACTTTCCCAAGTTCGGGTTCGGGCACGGCCAGGACGCCATCGCAGAGTTGGCTCGACGGCTCGATCTCGAACACCTCGAACATGACATCGAAGGCCTGGACATCATGACGAGCGGAGATCGCGTGATCGTCGAAGGCCGCGAGTGGGGCACCACCCGCGACGGCCACGCGTGGCCCGACGGCGAAATCTCCAGAGGTCTGTTCTGCAACGTGTTCACGTTCCAGGGCCACCTGATCAGCAAGCTCCACGTCTACACAGACCCGGACTTCACCAGCAGCCACCAGGAGAAGGTTCGGCAGCTCCACCGCGGCTGACCTTCATGGTTCCCTAGGCGAACCGGGCCTCCCGCCTCCATCTGTACAGGGCTCGTCAGCTTGCTGACGAGCCCTGTCTGCTCGCCCAGAGCGTGAGCTGGGCGGCGTGCTGGGTGTGGCACGGCAGCGCATGCCTGCTGTCAAGCAGAGGGGCCGGAAGCACACGCTATGGGCTGTTCCCGCGGTGGCGCCACGAGGGCCAGGTCGACGATCCGCAGAAGCTCTTGGCGCGTCAAACCGTGGGCAGCCTGTACCGCACAGACTTACATGCCGCACCTATGCCCGCACCGAAGAGCTCACCAGGGAGCACGGTGACATGGGCTTCATCGCGGCACAGACGATCGATGAGTTCGTGGACTCGCTGGCGAAGCCCAGGGTCGCCATCATCATGGTCCAGGCTGGCAAGGGCACCGACACGGTGATCGAGTAGCTCGCCGAACGGTTCGAGCCGGGAGACATCATCATCGTCGACGGCGGCAATGCGAACTTCCAGGACACGATCCGTCGTGAGCACGGCGTTATCTCTGGCGGTGAGGAAGGCGCTCTCAACGGCCCTTCGATCATGCCGGGCGGCTCGGACGAAGCCTGGAAGACGCTGAAACCGATCGTGGAGTCCATCGCCGCCGTCGCCGAGGGCGAGCCGTGCGTCACACACGTCGGGCACGACGGCGCAGGACACTTCGCAAAGATGGTGCACAACAGCATCGAGTACGCCGACATGCAGCTCATCTCCGAGTCATACGACTTGCTCCGTCGGCTGGACGGATACGACACCGACGATCTTGCCGAGGTGTTCACGAAGTGGAACGAGGGTGATCTGGAGTCGTACCTCATCGAGATCACCTCTGAAGTGCTGAAGCAGCAGGACGTGGAGACGTACAAGGCGCTCGTCGACGTCATCCTGGACGAGGCCGGAGCCAAGGGCACCGGCGCCTGGGCCGTGCAGAACGTGGCCAGACTCGGTGTCCCGGTATGCGGCACCCCTGCCGCCTCTTCTTCCTTGTGACGTGACCTCCAGCGCCACCGCAGCCGGTTGGTCAGGGGCTCCCTGTGCTCGGCCAGCAGGGCAAGCAGGCCCTGGAAGTCCGCAGTCCAGTCGACGCCGCAGGTCGCAGGCAGGACCCTACTCCTGCACTGAGTTCAACGGCTCCCGGCCCACCGTCCTGGAGAGGCGGGATCAGAAACGCCACCGCAGCCGCCGCAGTCCGATTACGACAGCTACCGAAAGCGTAACGTCGTCGTCCTCAAGGTGGTGCTGTGGAACACCCGTTACCTGAAAGGCCGTGGTCACCCGGCTCTACGCCAGGCGACCACGGCATCAAGGACGACGGCTCCAGCCCCTCTCGGCTCACCCCGGCGTTGCCGACTACCAGGCCGCACGCCCGCCGGTGCTCTCCCCCAAGGAGCTCGCGCTGACGAACGGGGCCAACGGCGCCACGCACCGGTCGGCGGTCACGGGATCAGCAGGAGTTTTCCCGTGGTTGTGCGCGACTCGATGTCCGCGTGCGCCTTCGCGGCCTCGGCCAGCGGATAGCGGCCGCCGATCCGGACGACCAGCTCGCCCTTCTCTGCAAGGGTGAACAGCTCGGCCGTGCGCGCCCTGAGTTCCTCGGGTGTGCGGATGTGGTCCTCGGTCACGCCGTAGGTGAGGCGGGTGCTGCGGGGGATGTCGTTCATCGCGATGGTCGGCACGTCACCGATCAGCGGTCCGTAGAAGACCATCGTGCCGTGCGTGCGCAGTACTTGCAGTGATGCGGCGAAGGTGCTCGCGCCCGCACCGTCGAACACCACGTGCACCCCCTCGCCGCCGGTCAGCTCGCGCACCGGCCCGACGAACGCGTCACCGGTGGAGACCAGGACGTGGTCGGCACCGGCGTCGGTGGCCCACTTGACCTTCTCCGGTCGTGACACCAGGCCGATCACCGTGCCTCCGCGGGCCTTGACGATCTGGGTGAGCATCATCCCGACCCCGCCGGCGGCCGCGTGCACGAGCGCGACGGCCCCCGGCCGTACCGGGTGGGACGCGGTGGCGAAGTGGTCCGCGGTCAGGCCCTGCAGGAGCAGGGCCGCGGCCGTCTCGTCGTCGATGGCGTCGGGCACCGGGACGGCACCATTCGCCGGGAGCACGATCTGCTCGGCGTAGCTGCCGTGGGTGTTGATGGTCAGCCATGCAACACGGTCACCCGGGGCGAAATCGTGCACGCCCTCGCCCGTCTGTGCCACCACGCCGACGCCTTCCGCGCCGGGTACCTCGGCCACGGCCTGGCTGCGGATGGCGGTGTCGAAGAAGTTCACGGCGCTTCGCCACCTCGGCATGAACCTGCGGCGCCGCCGCTCCTACGACCGCGACGCCCCCGAGTGGCACACGATCGGCCGCCGCCTGCGGCCCCTGGACGTCGCCCACGCGGCCATGCGCTGCCCGGACACCCCGCACCACCGCCGGGCCATCACCGACGCCATCGGCCTCATCCTGCTGCGGGCGGCTGAGTTGGAGACGGCCCAGTGGCACTTCGCCTCGCTGCCGGGCTCGGGCCATCGGGGTCTTGTCGCCGAGCTGGAACTGCACGCGGAATCCAGGTAGTCATGGGGTGCCGGGCCTGTAGTGATGGTGTGCTGCGCGCAGGGCGCGCAGCTGGTCCTCGAAGCTGAACGCGTCCACGGAGCCGGCGTACGGCGCCGGAAGCCAGACGACTTCGCCGCTGCGCAGCTTGGCCACGACACGGAGGTTGTGGGTGCTGAGGCGGCGGTCGCCGGGTTGTACCCGCACGTCCTCGAAGCGGTCGATCTCGTCCCACTCCAGTCGGTGCCACCGCAGCACTGTGCGGTACCGCAGCCCGTCCTGGCCCGCCTCCAGGCGGCGCCGGAGGAACCCGAAAGCCGTCAGGGTCCCCACAGCGAGGACCGAGGAGCAGCCCACCCACTGGTCGTGCCCCGGAACACCGAGACCGGCCGCGACCCCTGCCCCGATCGCCGCTAGCGCGGCCAGCGCGGTCGTCCAGCGTGCGGACGCGCCCATGATGCGGAAGGACAGCTCAGCATTGCTTGTCATCCTCGTGATCCTTCCATCCGCCTGCCGCCGTGCGTAGATCCCGTCAGGCCGCAATTTGATGACCATGCCCCCCGGTGCGGGACGGCACGGTCGTCCACGGCTGATCTCAGCGTCTTGAAGGGTGTCAATATCCCGATCAGGCCGTTGAGCTGGGTGTTTCTTGTGGATGGAGAAGTCGTTGGGGTGGCGTGGTGTGGTACTCGTCGAGCAGGCCGCCGAGTAGGGACCGGAGGCTTTGCGGCGGAGTCGGGATGACGGCTATGCCCCTCGAGGTCCATGGGCAGGTTGCGGCCGAGCTGGGTGACCCGTGCGCCCGTAGGGTAGGCGGTGACGCCCAAAACGTGGACGCGCCGAGTCTTGATCTCCATGACGAAGACGACGTACAGACGCTTGAGGAAGACGGTCTCCACGTGCATGAAGTCACAGGCGAGCAACGTGTGGGCCTGGGAACGGAGGAAGGACCGCCAGGTCTGCTGGGAGGCGCGCTGCGGTGTGGGCGGCGGACCGGAGCGGCGCAGGACACGCCGGATCGTGGCGGCGGCGACCCGATGACCGAGCCGTCGGAGTTCGCCTTGGATCCTGACGTATCCCCAGGTCGGGTTCTCTCGCGCCAGGCACTGGATGAGCACGACCGTCTCTTCCGCCGGCGGTGGCCGGCCGGGTCCGGTCGGGGTTTGGCGCCATTTCCAGCGCCCGAGACGGCGGTGCCAGGTCAGCAGTGTGCCCGGGGTGACCAGCCGGTGGCGGCGTAAGACGGGTGGAAGGTGCCGTGCGAGAGCGGAGAGCACGGCACGATCAGCCCATGAGAGCCACGGCCGCTCGACCTGTAGGCCCAGCACAGCGACCTCATGGCGGAGAGCGAGGATCTCGGCGTTGTTCGCGGCGGCCCACCGGCCCAGCAAAAGGAAGCAGCCCAGCAGTCGGCAGAAGATCAGGTAGAGCAGTCGCAGACCCACGATCAATGATCATGCCCAAACTTGGGCAATCGAAAAGCCCCAGGTCAACCACCGTACGGCAATAAAGACACCCTTCACGCATCGAATCTTGATCGGTGACAGGCCAGCTCACGAGGTCATAGCTTGTGTAGTCCCGTGTACGGGCTGACGATGCGGACTTCGTGCGAGCCGAAGTCGACGAGCATCGCGGTCTTGTCCTCGACACCGATGACCTTGCCCAGGCCGTACCGGTCGTGTGAGACCCGTTCCCCTAGGGCAAAGTGCTTGGCCAGCGGAGCAACCGGGGCCTTGAAGGGGCTCGTGGACAGGTGGCGCCGGAGCGCGGGTCGTTTCGTCATATGGGGCCATTATGCGCCGTCGAGGTTCCTGAACGGTCCGGGAGTCGCCAACGTCGACTTGATCCGGCTGCTCACCTGCGATCACCCGGGCCATCTGCGAACGGGAGTGCCGCAGCGGGCACAGCTCGATGAGCTCAGCGCCGTCGTCACCGAACGCCGTGGTCGGTCATCAGGCGGTGGCTGGCATCCATGCCGTGCACCTGCAGTCCGCGGAGGGGACGTGCTGGCCGATGGCGGAGGCCCGGCCTGCGACGGTGGGGATGCCGAGGCTGTTGACCAGCGCCGCGAGCGCGTCGGGGTGCATCGGCTGTCCGGCCCGGCGCCCGGGGAAAAGCCAGCGCGAATCGCCATTCGTCGCGGTGTTCATGTTGTCCCGGTTGCCGATCCGGTTGAGCAGGAGATCGGCGACCGGGGCGGGGACCGGGGATGGCGGTTCGCCGAGCCGTAGGAGGACCTGGTCTCCGTCATGGACCACGTCGTCGACGGCACCCCGTTACCGGCTCGCCCGGCGGCCACCGGTGGCCGTGCTGTTCACCGCCTGCTGCCGTGGCTGCGGTGCCGAACGCCGGTCCCTGGCGGCTCGTGCCCCGCCAGCGCCGAACCTCGCGAACCACCTTGTCAGTACTGCTCGGTCTCGACGAACCCGGCGTCGCCGGCGCCAAAGGCGTCGGCGGCAGCAATGGGGTCGAATCCGGGCGGGCTGTCCTTGAAAGCCAGGCCCATGCCGGCCAGCTTCGCCTTGACCTCGTCGATCGACTTCGCACCGAAGTTGCGGATGTCGAGCAGATCCGCCTCCGATCGAGCCACGAGCTCACCCACCGAGTGGACGCCCTCACGCTTGAGGCAGTTGTACGAGCGGACGGTGAGCTCGAGCTCCTCGATCGGCAGCGCGAGGTCGGAGGCGAGGGCGGTGTCCGTGGGGGACGGGCCGATGTCGATGCCCTCGGCGTCGATGTTGAGCCCGCGGGCCAGACCGAACAGCTCGACCAGGGTCTTGCCGGCCGACGCGATGGCGTCGCGCGGGTGCATGGCCGGCTTGGTCTCGACGTCGACGATCAATTTGTCAAAGTCGGTGCGCTGCTCGACACGGGTCGCCTCGACCTTGTAGGTGACCTTGAGCACCGGGCTGTAGATCGAGTCGACCGGGATCCGGCCGATCTCCTGGCCCTGCTGTGTGTTCTGCACGGCGGAGACGTAGCCGCGACCGCGTTCGACGGTCAGCTCGATCTCCAGCTTGCCCTTGGCGTTGAGGGTGGCCAGGACCAGGTCGGGGTTGTGGACCTCAACACCGGCCGGCGGGGCGATGTCGGCGGCGGTGGCCAGGCCGGGGCCCTGCTTGCGCAGGTACATCACGACCGGCTCGTCGTGCTCGGAGGAGACGACCAGCTGCTTGAGGTTGAGGATGAGGTCGGTGATGTCCTCCCTGACGCCGGGCACGGTGGTGAACTCGTGCAGCACGCCATCGATCCGGATGCTGGTGACGGCAGCGGCGGGGATCGAGGACAGGAGGGTGCGGCGCAGGGAGTTGCCGAGGGTGTAGCCGAAGCCCGGCTCCAGCGGCTCGATGACGAACCGGGAGCGGTATGCGTCGACGACCTCTTCGGTGAGAGACGGGCGCTGAGCGATCAGCATGAGGTGGTGCCTCCGATGTTCGGTGCCCGCTCTTTGATGCGGCACGGCAAGGATAGGGGTGGTGCGGCCTCACAAGAGGCCGCACCACCCGGCTCGGGGGGGCGTAGATTTACGCAGGATTGAACGGTGAGCAGGAGTGCCTGGTCAGCGAGGTGCCGGGCGGGTTAGCTGCGGTGGTCTCGGCGGGCGGACAGGTCTGTGTGGGCCTGGTCGTCGATCTCGATGAGGTAGGGGGCAACAAAGCCGTAGTAGTCCGCTTTGCGTTGGGTCGGTAGATCCTGCCAACCGGTGATGCGGCCGCGGCAGTGGCGCGAGCCGCACCGGCAGCGGGCGGCGAAGTGGTCAACCGAGTAGTTCCGCATCGCATAGTCGAAGGTGATCTCTTCACCGGCGGCGATGGGTGCGCGGCCGACGAAGTCGTGAGCGCCGCTGGAATTGAGGCGGATCCCGCAATTCGGTTCACACGAGTGGTTCACCTTCGGGACAAGCCCGCCGTGCAACACGAAACGTTCCGCACCGACCTGGGAGGCGTGGGAGTGGTTGCGGTCCAGTTCACAGTCGATGACACCAACCATCACCGTCTCACCGATCAGGAAGGGCCGGGTGGCGAAAACGCCTTCCCCTTTTCCGTCAGTTCTCCGGAGTTCGAAGCCGTTATCCATCGTCGCCTGCTCTCTGACGGATCAGCACGCCCGCGGGTGACCAAGCTACGGGCACGACAAATCGACGCGCCGCCGAGGGGCTCCTCGACCGCGGTCTGCTCATCCTTGCAGCACACCCGAGCGGCCATGGCCTTTTCGAGATCCGGGGGCCGATCCCCATCGAGGGCAATGCTGGAGTGTGCCGGAGCTGTGCCGTGGCGATCAGAACGGGTGGGGCTCGGCAGGCGCCGGGCCCTGGGCCTGCCCCGTGGAGGCGGAGGCCGGGCTCGCCACGGGGGCCGGTCCTGGCTGCGGGGCCGGGGCGGCAGGTCTTGGTGACGGTCGCTCTCGCGTACGTCAGGGACGCGGCGATCTCCTCGGCGTCGATCTCGACGGTGGTGCGGCGCTGGCTTTCTTTGTCGTCGATGGTGCGCTGCTTGAGCCGTCCGGTGACGATGACCCGCATGCCTCTGGAGAGGGACTGTGCGGAATTTTCGCCGGCCTGTCACCACGGTGAGCAGCGTAGGAACAGCGGTTCCTCGTCGACGAATTCGCTGCGTTCCCGGTCGAAGACCCTGGGGGTGGAGGCAGGATTATTCGCTTCAGCCGGATGCCGTCTCGCTCAAGCCTTGATGAGACTGATCAATTTCCTGTCAGACGGGACGGCGGGTTCCCAATTCAGGAACCCGCCGGAACCACCCGCACCAGCGACGCCAGCGGGCTGGGGTTATCGGGACTCTTCGCACATCAACGCGGCATCCCCACACGACAAGAGCCGCGTTCCACCAGGTCAGCGAATTCCGTCGGTGGCCCGGGGTACTACGAGTTCAGGCGCAGGCGTATGCGGTACGCCTCCTCCATCTTGGAGCGCAGCAGCGAAGCGGGGACCGCCTTGATGCCTCGCTCGCATACCCACCGGTTGTAGATCAGCAGCAGCTGTTCGGAGCCGTCGAGGAAGCCGTCCTCACGCGCTGGGATCGCCTTGCGCCGGGCGATGGTTTCCTGGGCCGGGTGGCTGGTCACGCGGTGCGCCGCGGTCCGGTAGGTGCCCTTGCTGTGGTGGTGGACGGAGCGGTCGAAAGCATCGGCGTCGGGGATGTCGCCTTCCTCAATGGCCTCGGCGTTTGACCCCGTCTCTACCGAGCCGTTCGAGGTAATAGGCCAGATAGGCGCGCTCGGCGTCGTAGAGGACGGCGAAGGATTCCGGGTCAGCGGCCAGGTGGTACATGCCACGCCTGAGCGGACCCGGGCCGCTCTCCTCATAGTAGAAGATGGCGTGGGCTTCTCATGGACGCGCGTAGGCGGCCAGCCAGCTACCGCCGTCCGAGTAAGACGCCTCCTCGGTGAGCATGGCAGGGCGGCCGCCGGCATCAGAGCCCCTGCCGCTGGAAAGGTCCCGGTTGGCGTCGACGATGTACGCGGCGAGCATGCGAGCGAGGTACGGTTCCAGGCCGTCAGGAATCCGGCGATCGAACTCCTCACCGAGCGCCAGAACTGCTGCGTGAGCGACACGGGCCATCGCCAGGCTGCGCGACCGCCACCCATCAGCCGTGGCCGCGACCAGCGCACGCCCCGCTACCTCTACGCCATCCTTCCCCGCACACAGCTCCTTTCCGCGCAATCCGAGGACATCCTTCACCCGCCCGATCCGGGACAGGTCCTCGCCCGGATCCGGGGCACGCGTGGCCGCCTGGGGATCGTCGGCCAGAGCGACGGTGGCGGGGGGCGCGGAACGGCAGTCAGGACGATCGTCAGCCAGTGTCGGGACCAGAACAGCGGCAGCTGTGCCCAGCACCACCACCGCAACCGAGAAGGTGACCACGCCACGCTTCTTGTCCTGCCGCAACCACATCCCATCACCCCACCTGTTACGGCCCGATATCATGTCCACGCCAGTCTGGCAGGAGCGTGGCGCAGACTTACCCCGCCGATCATGCGTCTCGCTAAGGTGACCTCGTGGAGAGGGCCCGATGAGTGCAGCGGGGATGAGCCGAGCCGAGGCAGTTGCCCTCGTGCAGAGGATCATGGATGCGGACTACGCCTCCGAAGAGGAGGCGGACAGCTGGCTGGACACGCTCGACAGGGCCCTGGCATGTCCGGCCGGACACGTCAGCGGCCTGATCTTCTGGCCACCGGAGCGGGAGCTCTCCGCCGACGAGGTAGTCGATCACTCCCTGGCATATCGGCCGATCGCCCTGTGACGACGCTTCCCTTCCATTCCGCTGTCACGGCCGACGCGTATGACGCCCACGGTCGGGAGGCTCGGCGTCCCCTCCCACGACCAGCCGGACATGATCGCCAGCACACCGACGCCGTGCCGGCGGAGTGCGGGACGCGCGGTGCGGCACGTCCGGGATGACGCCTCACTGGCCGACGGGCCGTCAGAAGTCGTACGGCTTCTCGGTGCTCCAGTTCAACACGTCGGCCTCGTTCCAGCTGAACTGCGGCTTCTCGCCCTTGGCGTCGACGGAGTAGAAGGGGCCGTCGTGACCGTCCGCGCCGCGCAGCGCGATGGCGAACGACTGCGCCGTCTGGTTCTGCGAGCCGTAGTCGAAGAGGTTCACCGCGCTGTATGCCCTGCCGCCGGGCTGGAGCGTGATGCGCTTGTCGCCGCCCGGGTTGTCCTTCTTCGAGTGCGGCAGTGCGGCGCCGTCGTCGCCGAGCCTCACGGCCGGGTACGAGATGACCCAGCATGGCTTGGTGCCCTCGTTCGACGCGGTGACCAGCAGGTGGTCGCCCTGCTGCCCGGCGAACCGGTGCACCGCGGTGACCAGCATCTCGTCGCCGCGGCACTGCCGGGCGGCGACCGCTGTGCCCTTGCTCGCGACCTCGTCCGACCCGCCCGAGGCGGTCGCCGAGCGCGCGCCCGCCTTGGTGTCACCGCCGCTGTTGGCCTGCTCCGCGCCGCCCTTGCCGTCCCCGTTGGACGCGGGCCGGCTCTGCGCGGTACCGGCGGCGTTGTCGGCGCCCGCCGCCTTCGAGCCGCCGTCGGCGCCTCCGCAGGCGGTCAGGCCCAGCGCCAGCGCGGCGGTGACGGCGGCCAGGGTGGCGGTACGAATCCGGGAAGTACGCATGATCAGGTTCCTCTGCGTTTCGTGCGGGAGTCTTCTTTGGCGGTTCCCGCGGTGTGGACACCACTTTTCCCGGGGCCACTGACGTTCTGGAAACGTCTCACTCACGTCCCGAAAACACACCGCGCGCGAACGGGTGAGGCCCAGCCGCGGGCGGCCTGGAGTTCCTCACCGCGGATCCGGCGCCGCACGCGGCCCCCAACAGTCTCACCTGCCCCATGGCCACCACCGACCGGCAGCACCGTCCCCGCTCCAAGGGTGTCCACGCCCCCTCCGGGCACAGGGCCGCCCTGTTCGCCTTCTTTTTCTTTTGCTGAGTTCAGTGAATGCGGAACCAACCCGGCCGTCGTGATCCAGCTCATCGAGGAGACCGACGGCCGTCGGCGCGTGCACAAGATCTGGACCGCACGGGGCGAAGTCGAGGGCCCGTCGTCCTGAGAGCACCCATCCCGGCCCGCACGGTACGAGAGCACCCTTCCCATGCCTGACATCGCGTGGACCATCCACGTGGCCGCCGTCACCGCCGTCACCGCCGTGGTGGCGACCACCGCGACGAAGGCCCACCGCCTCGCAGGGACGACCAGGCCAGCCGGGCCCGGCCGGCCGGTGCCGTTGTCGAGTGGTTACGAGGCCTGCCACATGGTCGCGGCGAACTCGATGCGCTCCGGCGGATCCCAGATGAGGTCCGGGCCTCCGCCCACGAACCGCGTGATCTCAGGCCGCACCACGTTGCCCTGATCAGTGATCAGGCAAAATCCGCTCTTGGGCTTGACCGTCCAGTCGTCCATGGCCAACCGGTCGAATCCACCCGTCTCGGCATCACTGGCGCATTGCTCCGGTGTCGAGGGGAGCGGCGCGTTCAGCTGGGCCGCAGGCCGCGAGCGCCCTGCCGGGCGGTCATCACAGCCGGAGGGCGAGGGCCTCGGCGTAGCCGAGGGGGACCGTGGCCTGCTGGAGGTCGCCTTCGGCGGCATACCGGCGTGCCATGTCTACCATCGTCACTGTCGGTGGTTTCTCAAAGGTGACCCGGTGCTGGTCTCCGAAGTCGGGCCCCCGGTCCGTTGGTTGATGTTGTTCATTCCCCTGTGTTGGCGGGTGGAGTCCGTCCGAGGTCGGGTCCGCGCATGCGGTAGCTGTCGCCCTTGAGTGAGATCACTTCGGCGTGGTGGACGAGGCGGTCGATCACGGCGGCGGCGACGGTGTCGTCGCCGAAGACCTCTCCCCAGCGATCTGGGGCTGGCACTTGTTCCCTCAGAAGAGTTGCCGCTGCCACCTGGCCGTATCCCGTTCCTACGGTCCTCGTTGGTTCTCGTGGCAGCGGCCCGGTTTTCAAGGTGCTGCCTTGACCGTTCAGGTGCGAGGAAGGTGTGCCGGTGGCCGAGGCGAGACTCCAGGTCATCGCGGGTGGGGTCGTCCCGCAGGAGCCGCTGACGACGGATCCGTGGCAGTTCCAGGCCGCGTGTGTCGATGCGTTCGTCGCCTCGTGGCGGGCCCGCGGGTTCAGCCCTGTGACCATCGACAACGACATCGGCCTGCTCGAACGGGCACTGGCCGCGCTGGGTCGGCCCGCGTGGGAGGTGACGCCGGAGGACATCGACCGCGTGGTCGGTGACCTGGCGGTGAAGGGCCGGGCGACCTCCACCCGGCGCGAGTACGTCCAGATCTTCAAGGGGTTCCACCGGTTCCTGCAGGCCCGCAAGGCAGCCGAGATCGAGGCCGCGTTCGGTGCCCGGCTGGTCTGCCCGGTTGACGAGTTCAACGCCTCCCGGCATGTCGGCGACGACTCGCCGGCCCTGGTGCCGCCGCCGACACCGGAGCGGGTGACGGAGTTCTTCGACTTCATGAAGCAGCGGATTGCCACCGCGAGAAAGTACGGACCCGCAGCCCGGGACTATGCGCTGTTCCGGACGCTGTATCACGCCGGGCTTCGGTCGGAGGAGGCATCGCTGTTGGAGAAGCCGGACGCGCACTTCAGCCGCGGCCCGTTCGGCAAGCTGCACGTCCGCTTCGGTAAGGGAGCCCACACCTCTGGGCCGCGGCCGCGCTGGGTGCCCATGCTCGACGGCCTGGACTTGGTGCTGCGGTGGTTCCTGGAGGACGTGCGGCCCAAGTTCCCAGACTCGCCGGTACTGTTCGCCGACGAGTCCGGCGGCAGCCTGCATCGTGGAACGATCCGTAACCGGCTGCGCTATCTGATGGAGCTCGAAGGGCGCCCGACTGCCGAGCGGTTCAGCCCGCATGCCCTGCGGAGGGCATGCGCGACCCACAACTACGAACGCGGCGTCGACCTGGTGGCCATCCAGCAGATGCTCGGGCACTGGACGGTCAGCTCGACCATGCGTTATGTCCGGCCCTCCGCGACGTTCATCGAGGACGCCTATCAGCGGGCCGTCGCCGGCACCCTGGCCGAGCTGACCGAGAAGGACACCACGGCATGAAGATCCGATGGCGGCTGCGGATGGCCGCTGCCCAGCGCGAGGTGTGGACCGGCACCGAGCTGCGCCGACTACTGGCTGAGAAGGCCGGCCTTGAACTGTCCTCCGCGTCGGTGTCCGCGCTGTTCACCAAGGAGCCCTCGCAGGTGAAAATGACCACCCTGGCCGCGTTGTGCACCGCGCTGGAGTGCACCCCGAGCGACCTGATCGAGGTCGACACCACCCCCGTCGAGCGGCCCGCCGCACCGCCCCGGCCCATCGCCGATCTCCCGCAGGCCGTCTCTGCTCGGGGCCGGTCGATGCCGCCCCTGTGACCGGCGGAGACTGCGGTGGGCAAGAGACAACGGGACTGCGTCAGCTGCGGCGGGCCGGTCGGTTATCGCGACCGCCTGTACTGCTGCCGGTGCTGGCGTCAGCTGAAAGAGCAGACCACGAAGGCGAGTTGTCCTTCCTGCGGCAAGGACCGGGTGCTCCAGGCGGACACCGGCCGGTGCATCACCTGCTCACGCGTGTGCGACCAGTGCGGCCATCCGGTGCGCGCGGCTGTCAACCGGCTGTGCCGAGACTGCCGCCGCAAGGCCGAGCGGCTCGCCGCCCAACAGCCCTGCCCGCGCTGCGGCAAGCTTGGCTATGTGCGGGAGGACACCGGGTGGTGCGGTTCGTGCTCGCGTCCGGGTCCGCCGAAGCAGCCACCGCAGGTCTGCCGCGAGTGCGGCCGACTGCGGCGGCATGCCGGGCTGGGTCTGTGCTCGGCCTGCTGGCAAAGGCATCCCGGCCGGCCCTTCATCCGCGGCGACAACCTCCGCGAAGTGCTCGCCGATCCGCCCGTGTGGCTCGCCGATTACGTCGCGCATGTCGCGGCCCGCTTCTGCGTCGCCCGGGCCTGCGGCCTCGTCACCGACCTGGGCCGGCTCCTGAACGACGAGCACTCCAACTCGCCCCAGGCCCTGCTGGAGCGATCCCGCAGGCCCGGACGGTCGATGGGTTCTTTCGCCCGCGCACTGGAGGACTTCTTCACCCTCCGCGGCCTGGCCCTGCCCACCGACCAGGCCGAACGGCTCGCCGCCGGGCGGCGCCAGCGCCGCATCGACGCCGTTCCCGTGCCCCTGCGGCTGGCCGTCACGGCGTTCGACGCCTCCCGGATGCGGGCCCAGGACCGGGCCCGCCGGGCCGGCACTCGCCCCCGCAGCGACCACACCCTGGAAACCGCCCTGAGCATCCTGCGCGACCTGGCCTGCTTCCTCGTCGAGCAGCGCGGCAAGGACGACTGGGCCCTGGCCGACGTGCACGACGTCGAAACCTTCCTCGCCACCGTGCCCAAGGCCCGCAAACGCCGGCTCGTGGTACTCCGGCAGTTCTTCCGCTTCGCCCGTTCCAATCACCTCGTGCTGGTCGACCCGACCCGCACTCTGATCGTGAAGGAGCCGAACGGCTTCCGCGGCCGCACTCTCACCCTCGACCAGCAGCGCGAGCTCTTCCGCCGCTGGACGACCGACAAACGCGTCCATCCGCACGAGGCTCTGCTCGGCATGCTCGCTCTGCTGCACGGCGCCTCCAGCACGGAGGTGCGGCAGTTGCAGATCGCCGACATCGACGCGGCGGCCCAGACGGTCCGGCTCGGCAAGCGGCCCCATCCCGTCCCGCTGGATCCCGCCTCCTGGACGGTCCTGCAACGCTGCCTAGCCCACCGCGAGGCCTGGCCAACGACCAACCCCCACGTGATGGTCACCAAAGGGACCAAGGCCGGGCGGAACCCAGCCTCAACTGCCTATCTCTCCCACGTCCTTGACGACTGCGGACACCCGCCACGGACTATCCGCAGCACCCGCCTCCTCGGCCTGGTCAACACCCTGGACCCCAAGCTCGTCGCCGCCGCCTTCGGCATGGACCCGCAGGCCACTCTGATCTACCTCGCCGACCGCGTCGACGAGGGACGTCTCCCGGCCTCGGAGCCGAGCCGGAAAAGATAGGAGACAGCATCAGGGAATCACGCAGAATTGCGGCCATGGCCGTCTTCTCCTGCATCGCCTGTCAGCAACGAATCAGCCCCCACCTCCGGGAAGTACCGATGCCGCCGCCGGTGACAGAGGAAGCCCCGGGACACAGGTTCCTGCCACCGCTGATGCCGCATGGGTCGTATGCGATCAGCCCTCACACTGGCGTGTTCATCCTCAATCCCGACGACGTCTCGGGAGTGACCAGACACCCTGACCGTGGGCGCCTCAACGGATGCTGCGGCCTCGATGGCCTGGACGGCCCCAACCTCGTCTGCGATGCCTGCGGAGCCGACGTCGCCACCCAGCAGTCGGACTGCTGGTCTCAACAGCTGATCGCGTTGATCCCCGATGCGGTGGCCACAACGGTCTCGCCCTCCGCTTGAACCTTTGCTGTTCAGGCACCGCCTCGCACGGGTTCGCCGGAACATGTGCGCTTTGCCGAAGGGCTTGTTGCTCGTGACGATCACGGAGGCGTGTTCGTAGCGGCCGGAGATGAACTGGAAGAACAGGTTCGCGGCCTCGGGTTCGAAGGGGATGTAGCCGACCTCGTCCACCACGATCAGCGGGATCCGGCTGAGCCGGGTGAGCTCGTCGCTGAGCTTGCCTGCCAGGTGGGCCTCGGCGAGGCGAGTGACCCACTGGGCGGCGGTGGCGAACGCGACCCGGTGACCGGCCTGACAGGCCCGGATCCCCAGACCGGTGGCCAGGTGCGTCTTCCCGGTCCCCGGCGGCCCCAGGAAGATCACGTTCTCTTTGCCCACCACGAAGTCGAGGGTGCCCAGGTGGGCGATCGTCTCCCGCTTGATCGACCGCTGATGGTCGAAGTCGAAGTCCTCGATCGACTTGCGGGAGGGGAAACGGGCAGCCCGGATACGGCCCTCGGCCCCGTGACTGTCACGGGCGGCAACCTCCCGCTGCAGACACGCGGCGAGGTATTCCTCGTGGCTCCATTCCTCCGACCGGGCCCGTTCGGCCAGCCGGCCGGCAGCATCCCGCAGAGCCGGGGCTTTCAGCGCCTTGGTGAGATAGATCAGTTCGGAGGTGACGTCGCGGCCCCTCTTCGCGGACTTCGTGCTGTTGCTGCTGGTCGGGGACATCACGCGACTCCTTCGCCTGTGGTCAGTCCGCCGTCGATGACGCCGAAGATCCGGTCGTAGGTCTCCAGGGGCCGTTGCTCGACCTCCAGCTGGTCCGCGGGCACCGGCCGCTGTCGGGCTGCCGCCCGGCCGGCTGCCGCCGCGGCCGCATGGGTGGGGTCGGTGATGGACAGGCTCACCGGGCTCAAAATCCTCCCTGAGCCAGGGCAGCAGGGCCCGACCCTCGTAGGATGCGAAATTCCTCGCCCCCGGCAGCTGGAATGCTGTGACTGAGTGCTTCAGTTGGCCAGTTGAGAAAGGGTGGCGCGCCCACACCGTCCACCCAGCCGGCCTCGCTGTCAGCGCTCTGTGTCATTATGCGGACGCGTCCCAGGGGAATGGGCCGCGGTCTACTGACTGCCAGGGGGTTGGGGATGGGCGCGGGTACGGAGCCGGACGGCTCGTCCAGGTCCGACGAGGAGTGGGAGCGGTTTCTGCGCGAGTCGGTGGCGGGTGCCGCCGACGCGCCCAAGGAGCCGTCGGCGCGGGCCCGCGACGTGGCAAAGCGGCTGCGCGCGGAGCCCGGCCGCGACCCGGAGGGCTGGCGCAGCTACACGCCCGCGCGGCCCAAGCGGCGCACGGGCTGGTACGTGGTCGGGCTGCTGGCCTCGCTGGTGCTGCTGGTGGTGGCGCTCGCGCCGGGGCCGATAGTGGACCTGTTCGCCGGCACCACTGACTCCCCGCCGCAGGCGGCCGAGACCGCCCGCCCGACCCAGGCACCCCCGGCGGAGGCAGCCCAACAGCCCACCGTGGAGGAGCCGTTCCGCGGCTCGCCGGCGGCGAGCTGGGCGAGCGGAGCGGCGGGGATCACCGTGCCGAAGGCCGGGGCGGTCGGCTGGATGAGCGCGGCCGAGGTCAAGCGGGCCCTCGCCCGCAGCCGAGACTTCCTCGTCGCGTCCGGCCTGGACCGCGGGGTGCTGCGGGGCGAGCGCCCCGAGAAGGCGATTGCACTGATCAACCCGCACCAGAAGGACGTCCAAGACCTTCTGAAAACCGCTTTCCGAACCCCGAGCGAGAAGAACGACCCCCTCCTCCTCTTCAGCCGCTTCCAGCCCTCCCGCACCCACCTGGTCGGCGACGTCGTGAAGACCCGGGGCCGGCTCACCTACCGGGAGGGCGAGCGCGGCGCGCTCCAGGTGACCGCCGACGTCACCTTCGTCTACCCGGTCACCCGCGCGGACGCGGGCGGCGACGAGATCGTGCGCACGATCGTCCGGCGCGAGCTGGTCCTGAGCTGGGACGACCCCGACAAGGTGATCACCGAGCCGGGCACGTTCTCGATCGTCTCGTACAAGTACGACATGACCAACGGCGGCTGCGGCGCCCCCACGGGCTACTTCATCCCGCCCTTCGGCACGGACCGCCCGGCGGACGAGGCCGGCACGGAGGTCGACCCGTACGACCGCAGCACGCCGGTCGGGCAGGGCAAGTCCTCTGGGGACGAGTGCAGGAGGGCGACACGGTCCTAGCGGGCGGCACTCGGTGGCGGCCACCCCAACCCCGAGGGCGATGAACATCCAGCCGCCGATCCGCTCCCAGCGCCGGCGCCAGGCCGGTCGGCCGAGCACCGCGCGCAGCCGGGCGGCGACGTGCACGAGCGCCAGCCAGTAGACGACGCCAATCGCGACATCGAGCGTGCCGAGTCAGCCACGTCCGGTACGCAGCACCAGTTGCGCTGGACAGTTCCGCGCTCAACGGCCGAGTGCAATGCTCACTGGCCAACTAGGACTTGTCCGGCCGATCATGTGACTACTGCGCCTTCGGGTTGTTGATGTGGACATGGGGCGGAGTGATCTGACGGACGCCGAGTGGGAACGGCTGCGGCCGTTCCTGCCGGTCAGCAGCAGGCGTTGTGGCAGGTGGCGGGATCACCCGCAGGTGATCGACGGGACCATCACCGTCGGTCGACCCCATGACGACCTCCTCGAAGGCGTGTTCGCCCGCACACCCGGAGACCCGGTGCTTCACCACCTGGCCGAGCACCTCGGAGTAGAACGCCAGTTGCGCATCGAGGTCGCGCACCACGATCTTGGCGAATACGAAGCCCTGGCCTTCAACAGCCATGTTCCCTCCACTGGAGCGGTCCGTCCCGGAGCAGTCGCCCGACCCGGACCCCCGGCTCGACGGCGGCACCCCGCCAGTACACCGGTTCGCCCCCAGGGCATTGACCACGTGTTCCAGTGAGCGGGAGGGTTCGTGCCAGCGGCACCACCCGCGCTTCGCTGCGCCCGTACGGTCACCGTACGCGCGTGTACTGGTTCACACCGCCGGCGAACGCCACCGTCGCCCGCCCCCGCAGCACCAGAACATCCAGGTGCGCGGCCGTCTCATTGACGGCGAGCATCTGGTTGAAGGCGCTCAGCTCGCCGAACGGCACTGCCCGGCGCGTCCATGCGAGCTTGTGCGCCACCTCGTGGGCGTCGAGCGTGTCCTCGCCCAGCGCCGCCAGACTCCTGGCCAGCCGTTCGTCGTGGTGCACAAGCAGCTCGGCGACCCGGGTGTGGGCGCTGTCGGCCACCGGTCCGTGCGCGGGCAGAAGGCGGGCGTCGGCGTAGCGGGTCATCAGCCGCAGCGAGTTCAGGTAGTCGGCGAGCGGACGGCCACCGGGCTCGGCCAGTTCGAAGCCGATGGACGGGGTGATGTGCGGCAGGACGTGATCCCCGGAGAACAGCAGCCCCCGCTGCTCGTCCAGGAAGACCACATGGCCCTTGGTGTGTCCGGGAGTGGGTACGACACGCAGCTCGCGGTCGCCGAAGCGGAGGGTCCCGGCGTCGAGCCAGCGATCGGGGGCCTCCCACACCCTTGGGTCGTAGCCGCCGTGGTCCATCGCCTCGATACGGTCGGCGAGCTCCCCGGCTCCCGCCGCACGCAGGGTCCGCAGTGAGCCGACGGGCTGGTCGCTGCGCAGTCGGTCGAGCATCTCCAGGCCCGGGCGTTCCCCCGCGCCGAGGTAGACGCGCGAGCCCAGCGACCGGCGCAGTTCCACCGCATGCGTGTAGTGGTCGCGGTGGATGTGGGTGACCAGGATGTGGCTGATGTCGAGGGGGTCACGGTCGATGGCGCCCAGGGCCTCCTCGAGCGCCTTGCGCGCCTCGGGGATCGCCCAGCCGCCGTCGATCATGACGATGCCGCCGTCGTCGGCCAGGTCCTCCAGGAGGTAGACGTTGACGGCGTGCAGGCCGTCACCCGGAAGCGGCAGGGGCACGCGGTGCACCCCGGGCTGTACCGTCTGGATTCCGGAAGCCGCCCACGGGCCTTGGCCGAACCGCGTTGTCATGATCCTCCTTGTTGGTGTACCGGCCTGGATCACGCCGGGTGACATGCCCGGCGGCACCGCCCGCGCATGCGCTGACTCGTCAGGGCCGGTCGGTCCCACGGGCATGCAGCCTGACGGCGAGGTCCCGGGCCCCGCCCCGGTCGAGCTTGCCGACCTTCGTCTGGGGCAGCTCCTCGATGCCGTACACGTACTCCGGCCACTTGGTCTTGGACAGACCGGCGCTCTCCAGGTGGCCGGTCACCTCGGCCAGGTCGATACCGCCGCCGTCTTCGGTGACGACGAGCAGCGCCACGCGTTCGCCGAGGACATCGTCGGGGACCGGCGTGACACAGACCCTGGCCACCCGCGGGTGGCCGGCGACCGCGCGCTCTATCTCGGTGATGTCGATGTTGCGGCCACCTCGGATGATGATGTCCTTCTCGCGGCCCATGATGGTGACGGTGCCGTCCTCGTGGGCCATCAGCAGGTCGCCGGTGGACAGATAGCCGTCCTCGGTCAGCGTCGGCGGATCGGCCTTCCCGTCACGGGCATAGCCGAGGAAGAGGGAAGGGCCGCGCACATGTGCCCGGCCGGTCAGACCGGTGCCGGCCACCTGACCGTCGGGGGTGAGCGCGTGCAGGTCCGTCCCCGGGAAGGGGCGGCCGTCTCTGCCGAGCCGGATTTCCTCGGCGTCGTCGGGGCTCGGCGAGGTGTGGCCCAGACACTCGGACATGCCGAAGACGCGGAGGATCTTCGTGCCCAGGGACCGCTCGGCGCGGGCCAGGGCTCCGCGGTCCATGGGCCCGCCGCCGACGGTGATCGACCGGACGCCCCGGAGGATGCCGGAGCCGGCCGCCTCCGCGCCCATCTGGAGCGCCATGGTCGGTACGCACATGGTCCATCTGACGCCGGTGTCGGCCATCCGCCGCAGTGCGACCGCCCTGTCCCACTTCCCTGTCATGACGAGCGGCCCGCGCAGCAGGAGGGAGAGGTAGACCCCGAAGCAGTACGCCGCCGTCGACGACAGGGGCACGATCGCGGCAACGGCGTCGCCCGGCGACAGGCCGTTGACGGTGATGGTGCTCGTGGCGGCATAGCGCAGGGCCCGCTCGGACTGTACGACGCCTTTGGCCCGCCCGGTCGACCCGGAGGTCAGGCCGATCAGGACGCCACCCGACCACCGCGACACCTCACGCCTGTGGGGTGTGGACAGGCACGTCCAGCCGTCGAGCACCGTCCGCGCCGGGCCGGGCAGCCGTGTCCGCACCGCCCACTCGTCCATCGCCGAGGCCTCGGCGACGACGGCGTCCGGGCGGATGTCCTCCCAGGCGGCGGTGAACTCGGCAGCTGTGGTGTGCCGGTTGATCAGCGCGATGACGCCGCCGTCCCCGCCTGCCAGGCCCACGGCAAGGGTGGCGGCCACGGTACGCCATGAGTTGTCCGCCTGGACCAGAACGGTGCCGACCGCTCCGTCGGCCGTGCCGGCGGAGAGCGCTCCGGCCAGCCGCGTGGCCTCGTCGAGCAGCTGCCGGGCCGTATGGCTGCCGAAGTCGTCGATCACGGCGACGAAGTCGGCTTCGTCCGCCCTCTGCTGGAACTCCCGCACTACCTGTCGCATCCTGCCCCTCGCTGCGCTGTGCCGAACTCCGTGTACTGAACGCTGCGGTGCTTACCGTGCCGGGGTCTCAGTTCTCAGGCGGTGAACATCTCCGCCTCGTGCCCCATGACCGCGACGCGGCGGCCCTTCATGTCGCCGACCTGGGCGACGGCATCGGCCCACTCGGGGCTCGCGAGGGCCTTCTTCAGGTCCTCAGGGGAGTCGAAGCCGAGCACGGAGATCCCGTCCCAGCCTTCGGAGCGCGGCTCCAGAGCGGCATCGATCTCGGTGTGCCGCCAGGCACGCAGCCCAGGCAGGCGGCAGGTCAGCTCCGCGTGGTCGCCGCGCCACCACGCGATGAACCGCTCGTGCGTCCACTCCGGGGGCCGGGCCGCCAGCAGGACAAGGTTGTACATGACAGTGCTCCGCACGGGGTCGATGGAATGTGGGCGATCGGTCGGACGGACCTTCGGTCAGGTGAAGCGGATCTCGGACGAGCGCCCGATCAGCAGGCGCTGCAGCCGTCCTTCGCCGTTCACCCGCCCGGCGGCGACGAAGCTGGCCTCGGGGACACCGGCGCGCCGTACCTCGCCCAGGAAGAGCTCGTCCTGGCCGAGCGTGGTCGCCGACAGCAGATGGTGGGTGCGGGTGCCCCTTTCGCGCTGTTCGAGGTAGCCCACCAGGGCGGCGCGGTCCCCGGCGAAGTCGGTGGCGTTGCCGTCGCCGGTGGAGAACAGGATGGACAGCGAGAAGTCGTCGCTGATCAGGTCGAGGATCCGGGACGGCTCATCGCCGTCGAGGATCTCGAACCACGCGGTGAGGAAGGGGGCCGCGGTCGGGGTGCCCGTCATACCCGGCTCCTGTCATCCGGCCGGGCCCAGTCGACCAGCTCGAACGACGTGGTGAAGAAGGACTGGTAGCGCGCCAGGAGCCCGCCGGGCGAGATCACCGCGGCCGAGAGGAAGGAGCCGGTGTACCGCCCGCCCTCCGTCACCACTCCGTACACGGTCTCGACGTCGCCGTCCCGGCTGTGGCGCAGGATCTCGTGCGCCCGGTCCACGGGATTGCGGCCGGCGATGTACGCGGCGAAGTCCTCCCTGGACTTGCCGGTGACCTCACGGCCCGGCAGGGCGATGAGGAACCGGAAGTCGGGTTCGAGCAGGTCCAGCGTCCGTTCCGGATACCGGCTGTCCATACCGGCCATATATGCGCGCAACGCCATGAGTGCGCCCTTTCAGTTGGCGGCCTTTCGCCAGGACCTCAGATCAACCTGAGTCAAGTTCAATTCAGTTTGGATGGTAATCCCGGAGAAACACGGCTGACAAGAGTCCGTGCACCGCAACCGTCCATGCCATCGGCGGTGCCTCGAACCCGGGCAGCACAAAGCCCCCGGCGGAGGTCCGGGGGCTGGAAACGGCAGAGTGGCTCAGGGATCAGGGCTCACGGCGTCACGTGGCGACCATCCGCACACAGGCACCCTCGATCAGCTCGCTGATCTCCGACAGCGGCGTCGGCCCCGACGGCCGGTACCACCGCCAGACGCTGACGATCAGACCGAGCACGCCCGCGCCCAGCAGTTGTGCGTCCCGAAGCGGGAACACGCCCATGGACATGCCCCGCACCAGCAGGTTCGTCCAGTCCCGCTCGACGAGCTGGACCAGCCGGCGGGCCTCGACGCGCTCGGCCTCCTCCCGCTTGGACTTGCGCGGGCCGGCGAGCAGGTCCATGTGGTTGTGCAGGATGCGCATCTGCAGGACCTCGTGGTCGGAGACGTCATACGCCGCGCGTACGGCCGCCCGGAGTGCCTCGACCGGGTCCGTGACGTCCGCGGTCGTCTCCGTGAACTTGTCGTGGGACCGCTTGAGCTCCAGCCGCATGATGGTGAGCAGGCAGTGGGTCTTGGACTCGAAGTAGTGATACAGCGCCGTCTGTCCGATGCCGACCCGCTCCGCCACGATGGACCACTTGGTGGCCTCGAAGCCCGTCTCGCCGAAGCAGTCGACGGCGGCCGCCAGGATGGCGGCACGCTTGGACCTCGGTCCCGCTTCCGGTTCAACGATCCTCGTCGCCATGTCCTGTCTCCTGGCCGCCGCCCGCCTCGTCGATACCCGAGAGTAGACCCAAGCTGAACTCGGTTGCCAATCGGCTCGGGGGTGGCTCGGGTCAAAGGCGCTCCAAGACGATCGCGTTCGCCATGCCGCCGCCCTCGCACATCGTCTGCAGGCCATGGCGTCCGCCGGTGCTGCGCAGTTGGTGGACGAGCGTGGTCATGAGCCGGGCCCCGGTGGCGCCGAGCGGATGCCCGAGCGCGATGGCGCCGCCGAAGGCGTTGACGCGGTCCAGGGGAGCGCCGATCTCCTTCTGCCAGGCCAGGACGACCGAGGCGAAGGCCTCGTTGATCTCGATCAGGTCGATGTCGTCGATCGACAGCCCGGCCTTCTCCAGGACCCTCTCGGTGGCGGGGATCGGACCGGTCAGCATGTGGATCGGGTCGGAGCCGACGACGGCCATGGTGTGCACGCGCGCCAGCGGGGTCAGACCGTGCCGACGCACCGCCTCCTCGGAGGCGATCAACAGGGCGGCGGCGCCGTCGGAGATCTGGCTGGAGACGGCGGCGGTCAGCCGGCCGTCCTCGGTGAGGGTCTTCAGGCCGGCCATCTTCTCCAGGGTGGTGTCGGCGCGCGGGCCCTCGTCGGCGGTGAGCCCGAAGGCCGGGGTGATCTCGTCGTCGAAGGCGCCGTCGGCCTGGGCGGCTAGGGCCCGCTGGTGGCTGGTGAGCGCGAACTCCTCCATGTCCGCGCGGGAGATGCCCCATTTCTCGGCGATCAGTTCGGCTCCACGGAACTGCGAGACCTCCTGGTCCCCGTAGCGTTCGCGCCAGCCGCTCCCCGCGTACGGGCTGCCCATGCCGGCCTGTTCGCCGACGGTCATGGGGGCGGCGATGGGCACCAGGCTCATCGTCTCCACCCCGCCGGCGACCACCAGGTCGGCGGTTCCGGAGCCGACCGCCTGGGCGGCGAAGTGCACGGCCTGCTGGGAGGAACCGCACTGGCGGTCGATGGTGGTGCCGGGGACGTGCTGCGGCAGGCCCGCCGACAGCCAGGCGGTGCGTGCGATGTTGCCGGTCTGCGCGCCGATCTGGCTGACGCACCCGAAGTACACATCGTCCACGGCGCCCGGGTCGGCGCCGGTGCGCTCCAGCAGGGCGCGCAGCACATGGGCGCCGAGGTCGGCGGGGTGCACGCCGCTGAGCGCGCCCTTGCGGCGGCCGACGGGGGTACGGACGGCTCCGACGATGAACGCTTCGGACATGGTGGCTCCATGGGTTTCGGGAAGGAGTTCAGGGCTTGAGCGCGACGCGCGTGAAGTCGGGCGTCCGCTTGCCCAGGAAGGCGGCGACACCCTCACGGCCCGCGTCGGAGGCGGCCGCGGCGGCGATCGCACGGGCCTCGCGGTCCAGGTGCGGACCGAGGTCCGCGGTCAGCCCGGCGGCGACGAGCCGGCGGGTGGCACCGAAGGCGGCAGTGGGTCCGCGCCGCAGGGCCTCGGCCGTGCGCGCGGCCTCGGCGGCCAGCCGGTCGGCGGCGACGACCCGGCTCACCAGTCCGATGTCCGCGGCCTCCGCCGCCGGGATGCGGCGGTTGGTCAGCAGCAGGTCCAGTGCTCGCTTGGGGCCGATGAGACGGGGCAGAAACCAGCTGACCCCGGCGTCCGGTGAGTAACCGATGCCGGTGTAGGCGGCGGTGAACGAGGCGTCGGCGGCGGCGAGCGTCACATCGGCGGACGCGGCCAGGCCGATGCCCGCACCCGCGATGGCTCCCTGCACGGCGGCCACCACGGGCGCGTCGCTCGCGGCGAACGTACGCAGGGCGTCGTGGAGCGCGGCGGTCACCGTGGTGAGGTGCTGGTGCAGTGCCTCGCCGGAGAGCCGGGAGAACTCCCTGAGGTCGCCGCCGACGCAGAAGGACTTCCCCTCCCCGGTCAGCAGCACGGCCCGTACGGCCTCGGCGGCGCAGGTCCGTGCCGCGTCCAGCAGTCCGCGCGCCATGTCCAGGTCGATGGCGTTGCCCGCCTCACCTCGGCGCAGGGTGACGCGGGCCAGGCCGCCGTCGTCGATCTCGATGCCGACCCTCATCGCGCGGTCCATCCGCCGTCGACGGTCAGGACCTGCCCGGTGCAGTACGAGGAGGCGTCCGAGGCGAGGAACAGCAGCGCGCCGTCGAGTTCATGCTCCCCGCCGCCGCGCCGCAGCAGGGTGTTGCGCTCGACCCAGCGGCTGGAGCGCTCGTCGCCGAAGAGGTCCGCGGTCATCTCGGTGCGGAACCAGCCCGGGGCGAGCGCGTTGACCCGGGTTCCCTCCGGGCCCCACTGTCCGGCCAGCTCCCGGGTCAGCCCGATCAGTCCGGCCTTGGACGCCGCGTAGCTCGCGCCGCCGAGCGGGGCGGCGGTGACCAGGCCGAGGATGGAGGAGACATTGATGACGCTCCTGCTCGGCGCGTGGTCCCCGGCGGGTGCCTCCGCCACGAGACGTGCCAGGTGGAAGGGCGCGGTGAGGTTGACGCCGAGGACATCCGCGAAGGCGCCCGGGGATTCGTCTTCGGCGCGGGTCTCGCCGGAGGTGGCCGCGTTGTTGACCAGGATGTCGATGCGGCCGGTGGCGGCCCGCGCGGTCCGGGCCAGCCGCGTACGGTCGGCGGAAAGCGAGACGTCGCAGGCGACGGGGTGGATGCGCTCGCCTCCGTCGGCGAGTTCCTTCAGCCGGTCGACACGCCGGGCGGCGGCGAACACGGTGGCGCCGGCCCGCGCGAGGACGGCGGCGAAGCGTGCGCCGAGCCCGGCGGAGGCGCCGGTGACCAGGGCCGTCCTGCCCTGGAGCGAGAACAGCTCCGCGGCGGGTCGTGGCGCGGTCATCCATCCACCCCGATCGGCAGAGCGGTCGCACCGCCGTCGAGCACCAGGGTCTGGCCGGTCATCCATGAGGAGGCGTCGGAGGCCAGGAACAGCGCCGCCTGTGCCACGTCCTCCACCGTGCCGAGGCGCCGCAACGGCAGCTTGGCGGTGAGGATCGGCTCGCGGACCTCCCACACCGCCCGCGCCAGTTCGGTCTTGATCAGTCCGGGGGCGATGGCGTTGACGCGGGCGCGTGGCCCGAGTTCGTAGGCGAGCTGCCGGGTCATGTGCAGCATGGCGGCCTTGGTGGCGTTGTAGTAGCCGATATGCGGATCGACGATGAGCCCGCCGACGGAGGCGATGTTGACCACCGCTCCCCCGTGCTCGGCCATCCAGGCCCGCCAGGCGTACCGGGTCCAGGAGATCATGCCGTACTGGTTGACGCGGACGGTCTTCTCCGCGCGCGGCAGGTCCAGGTCGAGCAGATCGCCGTGGTACGGGTTGGTCGCCGCGTTGTTGACGAGCACGTCGACCCGGCCGAAGCGGGACATGGTCTCGTCGACGCAGGCCTCGGCCTGCTCCGGTTCACCAGCGTTCGCCACCACCGTGTGAACGTCGCCGTCGCCCTTGACGCGCAGCAACTCCTCGCACGCCTCGGCGAGTCCGGCCGGCTTACGGGCCGCGAGCACCACATGCGCGCCGGCCGCCCGGTAGGCGGTGGCGATGCCCAGGCCGATGCCGCGGGATCCGCCGGTGATGACGGCGACCTTGCCGTCGAGGCTGTTGGCGCTCACACTGCCCCCGCCTTCGTGTCGGTCTTCGTGCCGGTCTTCTCGTACCTCGCGAGTTCCTGGCGGGCCACCGTCCGCAGATGCACTTCGTCGGGGCCGTCGGCGATTTGCAGCGCCCGTGTGATGGCGTACAGCCGGGCCAGTACGGTGTCGTCGCTGACCCCCGCCGCGCCGTGCGCCTGCACCGCGCGGTCGACCACCTTGTGCGCGACCTCCAGCGCCGCGACCTTGATCGCGGCGACCTCCATGCGGGCGGCGGCGTTGCCGACGGTGTCCATCAGCCAGGCCGACTTGAGGACGAGGAGACGCACCTGCTCGATCTCGATGCGGCTACGGGCGATCCACTCCCGGACCACCCCCCGGTCGGCGAGGGGCGCGCCGAAGGCGACGCGTTCGGTGACGCGCTCGCACATCAGCCGCAGGGCGCGCTCGGCGAAGCCCACGGCGCGCATCGCGTAGTGCATCCGCCCCGGACCCAGCCGTCCCTGGGCGAGCGCGAAGCCCTCGCCCTCACCGCCGAGGATGTTCTCCACCGGCACGCGGACGTCCTCGAAGAGCACGTCGCCGTGTCCGAGCCGGTCGGTGTAGCCGAACATCGGCAGGTCGCGCAGAACCGTGACGCCCGGGGTGTCCCGGGGGATGAGCAGCATGCTCTGCTGCCGGTAGGTGGGCGCCTTGGGGTCGGTCTTGCCCATCAGGATGATCAGCTTGCAGTCGGGGTCGAGGATCCCGGAGGTGTACCACTTGCGGCCGTTGACGACGTAGACGTCGCCGTCGCGGGTGATGCGGGTGCGGATGTTGCGGGCGTCGGAGCTGGCGACCTCCGGCTCGGTCATGGCGAAGCACGAGCGGATCTCCGCCTCGAGCAGGGGACGCAGCCAGCGCTCCTGCTGCTCGGGCGTACCGTACAGCGCCAGCAGCTCCATGTTGCCGGTGTCGGGCGCCGAGCAGTTGAACACCTCGGGGCCGATGACGGAGCGGCCCGCCAGCTCGGCGAGCGGCGCGTACTCCAGGTTGCTGAGCCCCGCGCCCCAGTCGCCGTGCGCCATGAAGAGGTTCCACAGGCCCTCGGCGCGGGCCTTCTCCTTCAGCTCGGCCATCACCGGCGGCAGGGCATGCGGGTCATGCGCCTCGGTGAGCTGCCGGTCGTAGACCCCTTCCGCGGGAAAGACATAGCTGTCCATGAACGACCGCATGCGGCCTAGGAGTTCACTCGCCCGGGGCGAGAATCCGAAATCCACGATTGCTCCTGTTCGGTGGGGCCGGATCAGCCGAGGATGTCGCGTGCCGTGCGGATCATGGCGGCGATGGTGGGCGGCAGACGCTCCTGGTCCGGGTCGTGGTGCTTGCCCTCGCGGTGCCGGCGCAGGTTGTGGCCCATGATCGCGGCCATCTTCATGCGGCCGAGCGCCCGGAACCAGTCCATCGCGGGCGGCGCGGGCCGGTCGTCACGGTAGGCGTCCAGCAGTTCGGCCTCGCCGGGCAGGCCGGGCACGGCGTGTCCCAGCTCGGGGAAGTTGTGGTGGTCGGCGAAGAGCAGGAACCAGCCGAGGTCGATGCGCGGGTCGCCGACGCTCCAGATCTCCCAGTCGATGACGGCCACCGCGCGCTCGCCCGCACACAGCACGTTGCCGAGCCGGAAGTCCCCGTGCAGCAGCGCCGGCGGGAGGCCGCGGGGCACGTCGTCGGCGAGGCGTGCCAGCAGCTCCTGGCCACCGGGGCGCAGTTCGGCGGGGACGGCGTGCAGGGTGCGGCTCCAGCGCTCCAGCTCGCCGACGGGGTCGAGCGGTTCGGGCGCGTCGAGCCCGGGCGTGTCGGCATCGGTGTCGTGCAGCCGCCGCAGGACGGATGCGATCTCCAGCATCCGGGCCCGAGCCGTCGCGGCGGGCACCTCGTTCTCGTCGAGTACCGGCTCGACGGCCTCCCCGGCGACGAAGTCCATGGCGAACCAGGCGGGTGGCCTCTCGTCGACGGCCACGACGCCCGGAACCGGCACCGCGGACCCGGCCAGCGCTCGCAGCACCCGTGCCTGGCGCAGTACGTCATTGCGTCCTACGGGCCGTTGCCCCGGGGGCACCGCCTTGACGACATACCGGGCGCCCCCCGCCGCGACCGAGTACGTCAGCCCCGAGTGGCCGCCTGGCAACACCGTCAACTCGCCGATCAGCGCCCCCGGGTGGCGGCGCGCGAGCCGGTCGCGGACCCGGGCGGCCGGCTCCGGCGCCTGGGTGGCCGTGTTCATCGGACGGGCTCCTTGGGCAGGCCGAGTACGCGTTCGGCGAGGATGTTGCGCTGGATCTCGTCGGTGCCGCCCGCGATGCTGTAGCCGGGGGCGCCGAGCAGGTGCTCCGTCCAGGCGAAGCTGCCCCATGCCCCCGTGTCCGCCACGAGGCTCGGGCCCAGCAGCTCGGACACCAGGTCGCTGGTGCGCCGCATGGTCTCGGTGGCGTACAGCTTGCCGACCGAGGCTTCCGCGCCGGGCTCGCGCCCGGCGACGAGGGCCGCGGTCACCCGCAGTCCGATGAGCCGCTGGACGAGGGTGCGGATGTGAAGGTCGGCGGCCCGCTGCTGTTCGCTGCCGGTGAGGGGGCGCGGCAGGTGCCCGGCCAGTTCCAGCGCCCGGTCGGCGTTGTCCAGGCCGAGGCCGCCGGAGTCGAGCCGCTCGGCGGCCAGCACGCTGAGTGTCACCCGCCAGCCCTCGCCGACCGGCCCGAGCCGGTCGGTGTCGGGCACCGTCACGCCGTCGAGGTAGACCTCGTTGAAGCTGGTGCCGCCGGTCATCTGCCGGATGGGCCGTACGGTGACGCCCGGCGCGTCCATGCGGACCAGGAAGACGGTGATGCCGGCGTGTTTGCGTACCTCCGGATCGGTGCGGCACACCGCCACGCCCCAGGTCGCGACGCGGGCTCCGGAGGTCCACACCTTGTGCCCGGTCAGCACCCAATCGTCGCCCTCGCGCACCGCTTTGGTCCGCACCGCGGCGAGGTCGGAGCCGGCTTCGGTCTCCGAGAACAGCTGACAGGCCAGCTCGTCGGTGCGCAGCATGGGCCGCAGCCAGCGCCGCTTCTGCTCCTCGGTGCCCCAGATGCCGACCGCGGGGGCGACGAGCGCTTGCGTCACAGGGAAGATCTCGGTGCGGTGCGGCACGTCGAAGGCCGCCTCTTCGGCGCGGTAGAGCTGCTCGTAGTACGCGGGCAGACCCCGCCCTCCGTATGTCTCCTCCCAGTCGAGCGCGGACCACCCCTGGTCGTAGCGGGTGCGTTCCCACTCCTGGACACGGGCGGTGTGCTCGCGCTCCTGCTCCTCGGTCCAGTTCTCGAACACGGCGACGGAGTCGGAGCCGCTGCCCCACTCCCCGTCGGCGGCGCGGGGTCTGCCGACGCCGGCGAGCCACTGCCGGGCTTGGGCGCGGAACTCCTTAGGTCCCGGGATGCCGCTCATCTCTTCTTCCACCTCCGATCGGCGGGACGTTTCAGCGGGACAGCACCGTGCAGGCGCTCACGCCGGGGGCGCCGTACACATGGGTGAAGCCGACCCGGGGTTCGCCGGGGACCTGGCGTTCACCCGCCCGTCCGCGCAGTTGCTGGACGACTTCGTAGACCTGGCGCAGTCCCGAGGCGCCGATGGGTTCGCCGTTGGCGATGCAGCCGCCGTCGGTGTTGACGGGCAGCGTCCCACCGATTCCGGTGCCACCGGAGGCGACCAGCCGCTCCTGCTCGCCGTCCTGGCAGAATCCGCACTCGGCCATGTGCATGACCTCGGCGCCGCTCTCGGTGTCCTGCAACTGGCAGATGTCGACGTCACCGGGGCCGATCCCCGCCTCTTCGAAGGCGGCGGCCGAGGCATCCCGGCTGACACTGGTCGGCTCGCCCCCGGGAATCCAGGGACTGAACACTTCGAAGGAGCCGAAGCGCCGGGTGCGAACGGCCGCCGAGCGCAGGGTGACCGGCGGGCCGTCCATGGTGCGGGCGGCCTCGGGCGAGCAGAGCACCAGCGCGGCGGCACCCGCTCCCGGGGAGCAGAACATGTACCGGGTCAGCGGATCGCTCACCATGCCGGAGTCGAGGATCTCCTCGGCGGACAGCGGTGTGCGGCGCCACGCCTCGGGGGTCAGGGCGCCGTTGCGGTACGCCTTCTCGGCGACCAGGGCGAGGGTCCGCGGGGTGATCCCGTGGTCGTGCATATAGCGCTGGATCTTCATGCCGAAGAACTGGGTGGTCACCATCAGCCCGTCGCTGCCGTACTCCGATCCCAGGCCCCAGTCCTCCGGCCTCGGGTCGAAGGCGCCGCGCGGGTGCTTGTCGAAGCCGACGGCCAGGACGACGTCCGCCATGCCGGAGCGGATCGCGTTCACGGCACAGACCAGCGCGCTGCCGCCGGTTGCGCAGCCGTTCTTGACGTTGACGAACGGCAGTCCGGTCAGGCCGAGTTGGGCCACCAGGGTGTCGGCGAGGCCCGCGCTGTCGCTGCCGCCGAACGCGGCCCGCACCCGCGACCACTCGATCCCGGCGTCCGCCAGGGCCGCGTTCACCGCGCCGACGGCCAGCTGCCGGCCGGTCGCCTCGGACCGGCCGAACGGGGTTCGCCCGGCGCCGCAGATCAGGACGTCGGTGCTCATGAACCCTCCTCGCCCGGGGTCGTGGGCCTGGCCCTCGGGACACCGGCACCCGCGGTCACGGTGAGGGGCATGCCGATGCGGAGGTCTTCGAAGTCGTCGACGTCGAGGACGGCGGCCACCCGCACGCCCTCGGCCAGCTCGACGTAGCCGAGCGCGAACGGCACGAAGCCTCCGGCCGGGGCCCGGTAGGGCGGCGACTTGGGGGCGTACCGCTGCACCGTCCAGGTCCACAGCGTGCCCGTGCCCTGGAGGGCCGCCGGCCGGGCGGGCCCCCCGCAGCGCGGGCACGCGTCGTCCGCGGGGTAGACCGCCACCGAGCAGCCGGAGCAGCGTGAGCCCTGGAGCCCGGCGGCCGGACTCCGCGGATCCGTGGCCATCCGGATCAGCGCCCCTGCCACTTGGGTTCGCGCTTCTCCAGGAACGCCGACACGCCCTCGTTCGCGTCCTCGGAGTTGAGCGCCACGCCCACGGCGAGGTGCTCCATCACCATCAACGACTGGGTGTCGGCATCCAGGCTGCGGTCGATCGTCATCTTCGTGAGCCACATCGTGAAGGGGCTCTTGTCAGCGAGGTCGCCGATGAAGTCCTCGACCGTCTCGTCCAGCTTGTCGGCCGGGGCCGACTTGTTGATGAGCCCGAACTCGGCGGCCTCGACGCCGGAGAGGAGCTTGCCGGTGAGCATCAGCTCCTTGGTCTTGCGTATGCCGATCATGCGCGGCACCCGGTAGATCGGGCCGGCCCCGCCGAACAGCGCGCGGCGGATGTGGAAGTCCCCGATCTTGGCGTCGTCCGCGGAGATGGCGAAGTCGCAGGAGATCATGATCTCGAAGCCGCCGGCGGTGACGTGGCCTTCCAGGACCGCGACCGAGGGGGTCTTCATCGAGTACAGGCGGTCGCACACCTTCGCGGACTTCACCGCGACGTCGATCGCGTTCGACTTGCCGACGTAGTCGGCCTTCAGGCTGTCGAGGTCGAAGCCCGAGCAGAAGGTGCCGCCGCGGCCGCGGACCACCAGGACCCGCAGCCCGGGGTCCTCGTCCACCTCCGTGATGATCTCGTCGAGCCGGTCCAGGATCGGCACGGTAACGCAGTTCTTCTTCCATGGGCGGTTGAGCCACACACGGGCGACGTGGCCGTCACGCTCGAACTGGATCTCGTCTTCCACTGTCATCTCTCACCCCTCAAACTGAACTGAATTCACTACAACACTGGAACCACGAAGAGACCCTGTCAACCCCTTCACCAAGGCAGGTTTATGGATTCAGACTCGCTCTTGATGAGATCACCTACTTCAGTTCAATATGACGGAGCGCCTCGCGCCGGCACCCCCTGCCGTCCAGATCGCTGAGGAAGGACCTCCATGCCCCGCATTTCCCGTCTCGGCATCGTCGGCTGCGGCCTCATGGGCTCCGGCATCGCCGAGGTCGCCGCCCTGCGCGGTCTCGATGTGACCGTCGCCGAATCGACCCCGGAGCTGGCCGCCGCCGGCCGCGCACGCATCACCGCCTCCCTCCACCGCGGCCTGCGGCGCGGCAAGCTCACCGAGTCCGACCGGGATCAGGCCCTGGCCCGGCTCTCCTTCACCCACGACCTGGGCGAACTGGCCGACCGGCAGTTCGTCGTCGAGGCCGTCGCCGAGAACCGGGAGGTGAAGCTGGAAGTCTTCCGCCGACTGGACAAGGTGGTCACCGACCCGGAGGCCGTCCTCGCCACCAACACGTCCTCGATACCCGTCGTCGACCTCGCCGTGGCCACCGGCCGGGCCTCCCATGTCGTGGGGCTGCACTTCTTCACCCCCGTACCGGTGCAGAAGCTGGTCGAGGTGATCCCCGCCCTCACCACCGGCGCCGAAACCCTGGCCCGCACCCGCGACTTCGCCGCCGAACGGCTGGGCAGGACGGTCATCCAGGCGCCCGACCGATCCGGCTTCGTGGTCAACGCGCTGCTGGTGCCGTACCTGCTCTCCGCGATCCGCATGGTCGAGTCCGGAATGGCGCGCGCGGACGACATCGACAGCGGCATGGAACTCGGCTGCGCCCACCCGATGGGTCCGCTGCGGCTGCTCGACCTGATCGGCCTGGACACGGCCCAGGCCGTCGCCGAGTCGATGTACGAGGAATTCAAGGAACCGCTGTACGCCGCTCCCCCGCTGCTGCGGCGCATGGTCGCCGCGGGACATCTGGGCCGCAAGAGCGGCCGGGGGTTCTACGTGTACGACGGATGACACCCTCCGCACCGACGGTCCGGCGGGCGGCCGGAATGACGTCGTTTCTCCGGAGACGGACTCATCGCGAAACCGGTGCCGGGCCGCCGCCGTTCAGGCGGCGGCCCGGGTGGCGAGACCGATGAGTCCGGCGAGGCGGACCCGGTGCCGGTCCGCCGTGCCGAACAGCACTTCGCCGCCGCGTGCGCGACGCATGTACAGATGGGCCGGGTGCTCCCAGGTGAAGCCGATACCGCCGTGCAGTTGGACGTACTCGGCTGTCGCCAGACGGAAGGTCTCGGAGCAGACCACGGCGGCGGCGCAGGCGGCCACCGGCAACTGGGGCGAGGCGACGGCGGCGCAGGCAGTCGCGTACGCGGACGCCGAGCGCGCCGCTTCCAGCGCGACCAGCACGTCGGCCAGCCGGTGCTTGACGGCCTGGAAGGAGCCGATGGGGCGCCCGAACTGGTGGCGCTGTGCGGCGAATTCGACCGTGGCGTCCAGCGCGTGCCCGCTGCCGCCGACCTGTTCGGCCGCCAGTGCGGCCCGCCCGGCGTCCAGAGTCGCCGAGACCGTGTCCTCGGCGCCCTCCGCCATGCCCACGGCGGTGGCCGGGGCGCCTCGGAACTCCACCAGCGCCTGGCGCCGCGTCTCGTCCAGGACACGGCGCGGAGTTCGCCGACAGGCGCCGGAGGCGGGCTCGCAGGCGAACAGCCGAGGTCCGGCGGGTGTTCCGGCCCGCACCACGATGAGATCCGCGCCGGCGCCGTCGAGCACGAAATCCGCCCGCCCACGCAGCACCCAGCCCTTGCCTTCCTGTTCCGCGGTGACACCGGGCTCGTCGGCTCCGAACCCGGCCACGGTCGCGGTGAGCGTGCCGTCCGCGATCCGGGGCAGATAGCGCTCGCATGCCGTACGGTCAGCGCTGTACAGCAGGGCGTGTGCGGCCAGGACCACCGTGGGCAGCAGCGGCGCGCAGTACAGGGCGCGCCCGGATTCCTCCAGGGCCACGGCCAGTTCGGCGAAGGTGAAACCCGACCCGCCGTACTCCTCCGGAACGGCCAGCCCATGGACCCCGATCTCGCCCGCGAGCCGCACCCAGAGCGCTTCGTCGTATCCGCGCGCGGTGGCCAGATGCTTGCGTACGTCCTCGGCGCCACTGGCCTCGGTGAAGAGGTCCCGCAGGACGGTACGCAGTTGCCGCTGTTCGTCCGATTCGGACAGCAGCTGAGGGTCGATCTCGGGGTGGCGACGGTGCATGGGGTCTCCATCGTGCTCGTACGACGGGGTGGCATCTGAGAATTGAACTCAATTCATGACCGTAGACACCGAGCCCCGCGCGGGCAAGACCTCCACACGGGCCGATTCGTGCATCTCCGACCCCGTCCGGACGCCTCCACGCGTCACGCCGATCGCCCTCCCCATCTACTGAACCAATTTCACCTCTGTTAACGTGGCGGCCTCGGGACTGACGAGACCTGGGACGGTGAAGATGAGGGCACTGAGGCTGACGGCGTGGGGCGAGCCCCCGGCACCGGCCGAAGTCGAGCGGCCCACGCCCCGTGGCACCGAGGTACTGGTGCAGGTGGAAGCCGCCGGGCTGTGCCGTTCCGACCTGCACGTCATCGACGGGGCCCCTGGGTCGCTCCCCTACCGTCTGCCGTTCACCCTCGGCCACGAGGTCGCCGGGCGGGCCGCGGCCCTGGGTCCCGACGCCGACGGGGTGGCGGTCGGTGAACGCGTGGTGCTCTACGGACCGTGGGGCTGCGGCGCCTGCGACCGTTGCGCCACGGGCCGGGACAACTACTGCGACCGGCGTGACACCCTCACATGGCATGGGGCCGGACTCGGCCGGGACGGCGGAATGGCCGAGTACCTCCTCGTCCCGTCCGCCCGCCATCTGGTGCCGATCGGCGACCTGCCGGCCGATCAGGCGGCCCCGCTCTCCGACGCGGGTCTGACGTCCTACCACGCCGTGGCCGGGCTCCGGCACGCACTCCGTGAGGGCACCTCCACTGTCGTCATCGGTGTCGGCGGGCTCGGTCACCTGGCTGTCCAGATCCTCCGCGCGACCACCACGAGCCGCGTACTGGCGGTCGATGTCCGGGAGGATGCCCTGGCTCTCGCGGACCGCTCCGGCGCGGACTTCGGCACCCTGATGCGGCCGGACACCGCCCGCGTGCTGAGGGCACGGACCGGTGACGCGGGAGCCGACGCCGTGCTCGACTTCGTCGGCACCGCAAAGACCCTGGAACTCGCGACCGGCGTCCTGCGCCCCGGCGGTGAACTCGCCTTCGTCGGAAGCGGAGGCGGCTGCCTGACGGTCTCCAAACCGGGCGTTCTCCCACCCGGCTTCCGGCTCTCGCTGCCCTTCTGGGGAACCCGCCCCGAGCTCGCCGAGGTCGTCACGCTGGCACGCTCGGGAGCCCTCCACGTCGAATCGGAACGGTTCCCGCTGTCCGCGGCACCGGAAGCGATCGGCCGGCTTCGGCGGGGCCAGGTGCGGGGCCGGACCGTGCTCGTCCCCGACTGACCACACGCACAGACGGCTTGGCGACTTTGACTCATGGACACGGAAGGGAAACCCCAGATGCGCTTCGACAAAAAGGTCGCGATCGTCACCGGCGGGGCCCGGGGCATGGGTGCCTCGCACGTACGCGGCCTGGCCGCCGAAGGCGCCCGGGTCGCCGTCTGCGATCTGCTGGACGACGAGGGAGAGGCCCTGGCCGATGAGCTCCCCCACACGCGGTACTGCCACCTCGACGTCACCGACGAAGCGCAGTGGCAATCCGTCGTCCGCACAGTCGAGGACACCTTCGGCCCCGTGGACGTCCTGGTGAACAACGCCGGGATCATTCACTTCGGCGGCGTGGTGGAGCAGTCGCCCGAACACTTCCGCCGGATCCTCGACGTCAACCTGGTGGGCGCCTTCATCGGCATGCACACCGTCCTCCCCGGCATGCGCGACCGCGGCCACGGGGCGGTCGTCAACGTCTCCTCGGCCGCCGGCCTCGTGGGTTTCGCCGGCGGCATCGGCTATGTGGCGAGCAAGTGGGGGGTGCGAGGGATGACCAAGGCCGCCGCACTGGACATGGCAGGCACTGGGGTACGCATCAACTCCGTACACCCGGGCGTCATCCGCACGCCCATGGGTGAGGACGCCTCACCCGGACTCTTCGCCCATCAGCCGGTGCCCCGCATCGGGGAGCCCGAGGAGGTCACCCGCATGGTGCTCTTTCTCGCCAGTGATGACGCCTCCTACACCACAGGCGGAGAGTTCCTCGTCGACGGCGGCCAGACCATCGGCCACAGCAGCCACTCCCCTACGACAGGGGATTAGCGCGATGCGGTGACCGGGGGTCACCGCAACCGACGCCCTACACATCCGTCACATCCGTGCGGACGGTGAACAGGACACCGATCCCGATCAGGCAGACCACCATGACGAAGAACGCCGGGGAGAGCAGGTTCCCGGTCCGCTCGACCAGGAAGGCCGCGATGTACGGAGCCGTACCGCCCGCGAGGACGGTGCCGATGTTGTACCCGATCGCCATGCCGGTGTAGCGGACCCGGCGTTCGAACAGATGCGGCCACAGACTGGCCGCCGGGACCTGTACGAACGCGCTGCTCAGCATGAAGAGCAGATAGGCCAGGCCGGCCAGGGCCAGGCTGTGCCGGCCCATGAGCATCATCGCGGGGTAGGCGGTCACCAGGAAGCCCAGCAGCCCGCCCATCAGGACACGACGGCACCCGAACCGGGCGGCGAGCCAGCCGGCCGGCACCATGAGCAGCACGGTGACGAGCACGACACCGGCGCTCAGCCAGAACACCAGCGTGGGGTCGTAACCCAGTTTGGTGGACAGGTAGATACCGATGTACGTCAGCCCCAGGAAGATGGCGCCGCCCTGCGCCATGGCCAGGCCGATGGACTGCAGCAGCGCGACGCGGTGGGTGGACAGGACCTCCCGGATCGGAGCCGCCGGGATGTCGGCACGCCGTGCGGCCTCCTCGAATTCCGGAGTGTCCTCGATCCGCAGCCGGGCCCACAGACAGACCAGGGTGAGTGGCACGGCCATCAGGAACGGCAGCCGCCACCCCCAGTCGGCCATCTGTTCCTTGGTGGTGAGGGCGGAGATCGCCCCGGCCGTGGCGGCCGCGAACATGAACCCGAGGTTGGACCCGATGGGTGTGACGGCACCGAGGAAGGCCCTGCGCCGGGGCGGCGCCGACTCGTAGATGTAGGTGTAGGCGCCGACCGACTCGCCCCCCGAGGAGACGCCCTGCACCAGCCGGGTGAGGAACAGGAGCACCGCGGCGACCACGCCGATCTGGCTGTAGGTCGGCAGCAGTCCCGTGATGCTGCTGGCCACTCCCATGCACAGCACGGAGGAGACCAGCGCTTTGCGACGCCCCCATCGGTCGCCGATCCACCCGAAGAAGACACCGCCGACCGGTCGTACCACGAGGCCGGTGGCGAACACGGCAAGCGCCGCCAGCGTCGAGGCCGCCGGATCGTCGCTGGGGAAGAACTGCGGAGCGATCGCCACGGCGAGATAGCCGTAGACGCTGAAGTCGTAGTACTCGATCAGGGTGCCGATGCTTCCGGCGAGCATCGCGCGGCGCACTGTACGTGGAGCGTACGGCGCCGACTCCGACCCCGGCGGGGCGGGCTGCTGTGTGGTGCTCACGATCCGGCCCTCCTTCCGACGGCACGGTCCCGTAACCCTGCCGACGCCCGGGACGGTACAGAACTGAACTCAGTACAGCTAGCCTTTGAGCAAGGGTTTCCTCGGAGTGCGCGACGGATACCCGGTGGAATGACGTGCGCGCGGCCGAAAGCGGCGCCTACCCCTTGAGGATTTGAATTGGATTCGGTTTACTCACACAGGGGATCGGGCGAGCCGCCGAGCGGTCGCGCGCCCACGACGCGGAGCGCGATGTCGCCGTACTGGTAGGCGAGTTGATCGACGGTGAACTCGCCACCCTCGTGAAACCAGCTGGAGACGCCGATCCCCATGTCGAGGATCGAGTACGAGGCGATCCTGGCCGACTGCACACGGAAGGCCCCCTCGGCGGCACCCCGCTCGATGAGTTCACGGAAGCGGCGCTCGTAGTCGCTGCGGCGGCCGAGGACCCGATCCTGGGCGGGCTGCTCCAGGCTGCCGATCTCGCGGTTGCCGACGAATGCCTCCAGGCGGTGGCGGGCGTGGTAACGGATATGCGCCTCCACGGAGCGGCGAAGCTGCTCCCGCACGTCGTCCGCGCCGGCGACGGCCGCGATGTTGCCGGCGATGAGCTGCTCCATCGTGCCGATCATGATCTCGGCCAGCAACTCATGCTTGGAGGCCACGTGTTTGTAGAGACTCGGACCGCGGATGCCGATGGCGGCCCCGATATCGGCCATGGTGGTGGACCGGTAGCCCTGCGCGGCGAACAGCCGCAGCGCGGCCTGCCGGATGGCCGAACGGCGGTTGGCCGCGAGCGCGGCCTCCGGCCGCGCCGGCCGATGCGGCCGCTCGTATGCCCCGCCTTGGGCTGAGCTCATACGGACTCCTGATGCTATCGATGGTTAGCCTATTCCACTTTGCCGAGCTGTTCACCCTAGCCCGCTCCCTTGACACGCCCGCCCTTCTGCCCATGAGATGGCTAATGCCCAGTAGCCAAGCTCGGGAGTGAAGGTGTCCATCGGGTTCGAGATCGACGAGAGGGTCGCGGAGATCGCGCGGCGCACCACCGAGTTCGTACGGGATGTGGTGATATCCGAGGAGCAGGCGTGCGACGGCAATGTCCATGCCGGACCCGAGCCGCTGCGCCGCCGCCTTCAGGGCGCGGCCCGCGAGGCGAGGGTGTTCGCGCCGCATGTCGGCGCCAAGTGGGGCGGACTCGGGCTGGACCTGTGCGGGCAGGCAGTGGTGTTCGAAGCGGCCGGGTACTCGCTTCTGGGACCTCTCGCGCTCAACTGCGCGGCGCCCGACGAGGGCAATGCGCATCTGCTCGAGGTAGTGGCCACGGAGCAGCAGCAGGAGCGGTACCTGCGCCCGCTGGCTGCCGGTGAGGTGCGCTCGTGCTTCGCGATGACCGAGCCGGCGCCGGGCGCCGGCTCCGACCCGCGTGCGCTCACCACGACCGCGACGAAGACCGACGGCGGCTGGCGGATCGACGGCCGCAAGTGGTTCATCAGCGGCGCCGACGGGGCGGCCTTCGCCATCTGCATGGCCCGCACCTGCGGCGGCCCCGGCGACGCGGGCGGCGCGACGATGTTCCTCGTCGACGCCGACAACCCCGGCATGAAGATCGTCCGGAATATCGACACTCTGGACCAGGGGCTCTTCGGCGGGCACAGCGAGATCGTCTTCGAGGGCTGCGAGGTCGAGGACACCGCCGTGCTGGGCGAGGTGGACCAGGGATTCGCGTATGCCCAGGTGCGCCTGGGGCCCGCGCGCATGACCCACTGCATGCGCTGGCTCGGAGTGGCTCGGCGAGCGCAGGACATCGCCCTGGAGCGCGCGGCGGACCGTTCGGCCTTCGGCAAGCCGCTGGCCGAACTGGGCATGGTGCAGCAGCTGTTGGCCGACTCCGAGATCGACATCGAGACCGGCCGGGCAGTGCTGTGGCGGGCCTGCTGGGAACTGGACCAGGGCCGCCCGGCCGCCCAGCACACCTCGATCGCCAAGACCTATGTCTCCGAGGCGGTGAACCGGGTGGTCGACCGGGCCGTGCAGATCTGCGGTGCGCTCGGCATCTCGGGGGACACCCCGCTGTCGCGGCTGTACCGGGAGGTGCGTCCGTTCCGTATCTACGACGGTCCCTCGGAGACCCACCGCTGGGCCATCGCCAAGCGCGCGGTGCGGGCAGCGCGGGAGCGGAGGGCCATTCGGTGACCACCTCCGAGACGCCGGTGGCCGGAGTCGACGTGGCCGCGCTGCGGCGTTATTTCGAACGCCACGTACCCGAGTGCGCGGGCCCGTTGAAGGTGACGCCCCTGCACGGCGGTCGCTCCAATCTCACCTACGAGGTGACCGACGGGACACGCCGGTGGGTGCTGCGCCGACCGCCGTTGGGGGTGCTGACACCGACCGCGCACGACATGGACCGCGAACACCGCGTCGTCGCGGCGCTCGGCGGCACCGGGGTGCCGGTCGCCCGGGCCGTGCTGTCGTGCACGGACCCGGAGGTGATCGGAGCCCCGTTCTGCGTCGTCGGCTTCGTGGAGGGCACGGTGCTGCGCGACGGCGACAAGGCAGCCGCACTGCCGCCCGACGACGCACGGCGCGCCACCGACGCGCTGGTGGACGCCCTGGTCACGCTGCACTCCGTGGACGCCGCCGCCGTCGGGCTCGGCAAGTTCGGCCGTCCCGACGGCTATCTGGAGCGCCAGGTGCGGCGATGGCGCGGACAGTGGGACAACGTCGCCACGCGGCCCCTGCCCGACCTCGACGAACTGCACGGCAGACTGGCCCGCGCCCTGCCCGAGAGCGGCACCCCGGCCATCGTGCACGGCGACTACCGCCTGGACAACACCATCCTGGCGCCCGACTTCGGGCGGATCGCCGCGGTCGTCGACTGGGAGATGGCCACGCTCGGCGATCCTCTGGCCGACCTCGGGATGCTGCTCATGTACTGGGATCGGACCTGCGAACCGGTCCTCGGGGCGCGCCACGTCCCGACGGCCAACCCCGGATTTCCCTCGGGCCCCGAGCTGGCCGAGCGATACGCCGAGAAGTCCGGCCGGGACATCGGCCTCCTGCCTTACTACCAGGCGATGGCCTGTTTCAAGCTCGCCGTCATCGCGGAGGGCATCCACGCCCGCTACCGCGCGGGACAGACGGTCGGAACCGGATTCGAACGGGTCGGCTCCGCGGTGCCCGCGCTGCTGGGCTCGGGGTTGGAGTTGCTGCCATGACCACTGACACACCGAACGAAGGAAAGCCCGTGCGAGACCGACTGTCCGGACAGATCGCCCTGGTCACCGGAGCGACCGGCGGCATAGGCGCCGCCGTCTCGCGCCGACTGGCCACCGAGGGCGCCACGGTCGTGGTGACCGACGTGGACGCCGGGCGCTGCGACCGACTGGCGGCAGAGCTGACGGCCGATGGAGCGCGGGCACTGGGCCTCGCGCTGGACGTGAGTGACGAGGAGGCGTGGCGCGGCGCGGTCGAGCGCGTGGTCTCCGCATGGGGTGGCCTGTCGGTGCTCGTCAACAACGCGGGTATCGCCGAGATGCGCACTGTGGAGACGGAGACCCAGGAGTCGTGGGACAAGGTCATCGCGGTGACCCAAGGCGGTGTCTGGCTCGGCATGAAGCACGGTGGACCCGCGATCGAACGCTCCGGTGGCGGCTCGATCGTCAACATCGCGTCGATATTCGGCACGGTCGGCGGCTTCGGAAGCCAGTTCTCCTACCACGCGGCGAAGGGCGCGGTCCGGCTGATGACGAAGAACGCCGCCCTGCACTGGGCCACGCGCGGCGTCCGGGTCAACTCGATCCACCCCGGTTTCATCGAAACGCCCCTCTCCCGCGAACTGTGGCGGGGCACGCCCCGCCACACCGCGATGGTCGAGGGCACCCCCATGAGGCGGCTCGGCAGGCCGGAAGAGGTCGCGGGGGCGGTCGCGTTCCTCGCCTCCCAGGACGCGAGCTTCGTCACGGGCTCCGAGTTGTACGTGGACGGCGGCTGGACGGCACGCTGACCGAATAATCGGTGCTGCCGCGCGCCGCCTGCTTCGAGCCGCGCACCGCGGCGAGGCCGATGAAGATCATGGACGACACACCTGCCAGTGCGAAGGCGGTGAAGCCCCAGTCGCCATTGCCCGCCGCGAGCAGCCGGCCGCCGAGCCACGGCCCGAAGACGGCGCCGAGGCGGCCCGTGCCGGAGGTCCAGCCGACGGCGGTGGCGCGGTTCTCCGAGGTGGAGCGGATCGAGACCGTCGCGTAGACCATGGTCTGGGCGCTGTTGAGGAACACGCCGGTGAGAAAGACGACCGTGAACGTCAGCGCCAGTGGCATGTGGATGCTGAGCAGGAAGACACCGGCGGCGGTCAGCGCGAACCAGATCGCCGAGATGCACGGCGCGCCGAAGCGGTCGGAGGCTCGGCCCGCGACCAGCATCCCCACGATGCCGCCGAGGTTGAACAGGACGACGAAGGTCAGCGTGGAGCCCAGCTCGTAGCCCTCGCCGCGCATCAGGGTCGGCAGCCAGGTGGCGACGCCGTAGACCAGCAGCGTGTGCCTCGTTCGTGATCAGGATGTGGTCGAGGGCTTCAGCCGTCCACTCCGACCTGCACCGCGAACGCCCCGCGCTCCACATCGCCCATCGGCAGCCGGTAGGAGTCCGCACGCTGTCCGTAACGCTCCTGCCAGGACACATCCGCGATCCGGGCCGCACGCAGCCAGTCACGGCGGCGACCGCCAGGGCCTCGAGCGCGCACCGCAGGGTCTCTGCGCAGAACTCCAGCCGGTTCACGTCCCTCACCAGAGCCAGGACATGGGTGGCGTCCGTGCGCACACGTCCGCCCGCGCGCAGGAAACCCAGCCCGGACAGCTGGGACAGCAGCCGGTCCAGGAGCACCTGCTCGTGGCTGTGCTCAACCAGGCGTGTCCGGAAGCCGGAGAGGACGGAGAAGTGGAAACCCTGGATCCTCCAGCTCCAGCCCGAGGAGATATTTCCAGTCGATCCTGGAGCGGACGGCATCAGCAGCCTGGCGGTCCGTCAGCTGCTCAGCGAACTGCATGACCGACACCATGGCCGGCATCCCCGGTGCAAGACCCGGCCCGCCCCGGGCCGGGAACGCTGCCGCGAAGTCCGCGTCCTGGAACAGCACACCCAGCTCGTTGCGGACCCGCATCGCCAGACAGCCTTTGGGGAACGCCGCCCTGGCCACCCGAGCGGTCGTCTCAGGGGTCTCGGGAACGGGGACAGGACGCAGCGACAC

Protein sequences of DBSCAN-SWA_7

>NC_016582|11680346:11733773|11699131_11699668_-|WP_143675769.1|DBSCAN-SWA
MVTFSVAVVVLGTAAAVLVPTLADDRPDCRSAPPATVALADDPQAATRAPDPGEDLSRIGRVKDVLGLRGKELCAGKDGVEVAGRALVAATADGWRSRSLAMARVAHAAVLALGEEFDRRIPDGLEPYLARMLAAYIVDANRDLSSGRGSDAGGRPAMLTEEASYSDGGSWLAAYARP
>NC_016582|11680346:11733773|11693508_11693811_+|WP_162097959.1|DBSCAN-SWA
MSKKFTALRHLGMNLRRRRSYDRDAPEWHTIGRRLRPLDVAHAAMRCPDTPHHRRAITDAIGLILLRAAELETAQWHFASLPGSGHRGLVAELELHAESR
>NC_016582|11680346:11733773|11684594_11685488_+|WP_014182366.1|DBSCAN-SWA
MSKPGQTVEIPHLGGSTVGYTFGKPYDPALPTLVLINSYTTSAELYRPQFADPELGSAANLLALEPYGHGRTRAAYQHFTYWDSAVANLQALEALGIDEAFVLGTSQGGWVAVRMALLAPDVVKGLIPLGTSMDFESPRSRDLGCWDGIGSNTPLVDALADPVGEDWVVPDEVVDAVFAAALGGVSAEEREFWLTAYRANYSGDAGRHRLRLSTVNLRDRDGLHGRLDEVRCPVLWLHGTADQVYSVPNAQEEIQMFTSSPEARLEIIEGGQHFLSASHPAEVGSAAIEFLKRWARA
>NC_016582|11680346:11733773|11703351_11703666_+|WP_014182391.1|DBSCAN-SWA
MKIRWRLRMAAAQREVWTGTELRRLLAEKAGLELSSASVSALFTKEPSQVKMTTLAALCTALECTPSDLIEVDTTPVERPAAPPRPIADLPQAVSARGRSMPPL
>NC_016582|11680346:11733773|11712185_11712560_-|WP_014182401.1|DBSCAN-SWA
MALRAYMAGMDSRYPERTLDLLEPDFRFLIALPGREVTGKSREDFAAYIAGRNPVDRAHEILRHSRDGDVETVYGVVTEGGRYTGSFLSAAVISPGGLLARYQSFFTTSFELVDWARPDDRSRV
>NC_016582|11680346:11733773|11695742_11696048_-|WP_014182378.1|DBSCAN-SWA
MVHDGDQVLLRLGEPPSPVPAPVADLLLNRIGNRDNMNTATNGDSRWLFPGRRAGQPMHPDALAALVNSLGIPTVAGRASAIGQHVPSADCRCTAWMPATA
>NC_016582|11680346:11733773|11697369_11697867_-|WP_014182380.1|DBSCAN-SWA
MDNGFELRRTDGKGEGVFATRPFLIGETVMVGVIDCELDRNHSHASQVGAERFVLHGGLVPKVNHSCEPNCGIRLNSSGAHDFVGRAPIAAGEEITFDYAMRNYSVDHFAARCRCGSRHCRGRITGWQDLPTQRKADYYGFVAPYLIEIDDQAHTDLSARRDHRS
>NC_016582|11680346:11733773|11706445_11706625_-|WP_014182394.1|DBSCAN-SWA
MSLSITDPTHAAAAAAGRAAARQRPVPADQLEVEQRPLETYDRIFGVIDGGLTTGEGVA
>NC_016582|11680346:11733773|11713501_11714650_-|WP_014182403.1|DBSCAN-SWA
MSEAFIVGAVRTPVGRRKGALSGVHPADLGAHVLRALLERTGADPGAVDDVYFGCVSQIGAQTGNIARTAWLSAGLPQHVPGTTIDRQCGSSQQAVHFAAQAVGSGTADLVVAGGVETMSLVPIAAPMTVGEQAGMGSPYAGSGWRERYGDQEVSQFRGAELIAEKWGISRADMEEFALTSHQRALAAQADGAFDDEITPAFGLTADEGPRADTTLEKMAGLKTLTEDGRLTAAVSSQISDGAAALLIASEEAVRRHGLTPLARVHTMAVVGSDPIHMLTGPIPATERVLEKAGLSIDDIDLIEINEAFASVVLAWQKEIGAPLDRVNAFGGAIALGHPLGATGARLMTTLVHQLRSTGGRHGLQTMCEGGGMANAIVLERL
>NC_016582|11680346:11733773|11728716_11729385_-|WP_014182418.1|DBSCAN-SWA
MSSAQGGAYERPHRPARPEAALAANRRSAIRQAALRLFAAQGYRSTTMADIGAAIGIRGPSLYKHVASKHELLAEIMIGTMEQLIAGNIAAVAGADDVREQLRRSVEAHIRYHARHRLEAFVGNREIGSLEQPAQDRVLGRRSDYERRFRELIERGAAEGAFRVQSARIASYSILDMGIGVSSWFHEGGEFTVDQLAYQYGDIALRVVGARPLGGSPDPLCE
>NC_016582|11680346:11733773|11716245_11717022_-|WP_014182406.1|DBSCAN-SWA
MSANSLDGKVAVITGGSRGIGLGIATAYRAAGAHVVLAARKPAGLAEACEELLRVKGDGDVHTVVANAGEPEQAEACVDETMSRFGRVDVLVNNAATNPYHGDLLDLDLPRAEKTVRVNQYGMISWTRYAWRAWMAEHGGAVVNIASVGGLIVDPHIGYYNATKAAMLHMTRQLAYELGPRARVNAIAPGLIKTELARAVWEVREPILTAKLPLRRLGTVEDVAQAALFLASDASSWMTGQTLVLDGGATALPIGVDG
>NC_016582|11680346:11733773|11700227_11700920_-|WP_014182385.1|DBSCAN-SWA
MRTSRIRTATLAAVTAALALGLTACGGADGGSKAAGADNAAGTAQSRPASNGDGKGGAEQANSGGDTKAGARSATASGGSDEVASKGTAVAARQCRGDEMLVTAVHRFAGQQGDHLLVTASNEGTKPCWVISYPAVRLGDDGAALPHSKKDNPGGDKRITLQPGGRAYSAVNLFDYGSQNQTAQSFAIALRGADGHDGPFYSVDAKGEKPQFSWNEADVLNWSTEKPYDF
>NC_016582|11680346:11733773|11688876_11689536_+|WP_014182370.1|DBSCAN-SWA
MTTIGIIGAGEVGSQIARAALANGYEVVIANSRGPETLENLVAELGPSARAARATDAAAAGDFAVVAVPLKLVNDMPVEGLAGKIVLDTNNYMIWRDGHFDVIDSGEKTVLELRQEHLPTSKVVQAFTHIQAPRITTAGRPSGTPDRLALPTSSNFPEAVALVTRLYDQFGFDTVDNSPLSESWRTAPGQPAWTELAHQTRDKLTVNLTRARRISQAPS
>NC_016582|11680346:11733773|11681247_11682081_-|WP_043488355.1|DBSCAN-SWA
MNDLPLTLMAVHAHPDDEATGTGGVLARYAAEGIRTVLVTCTDGGCGDGPGGVKPGDPGHDGAAVALMRRQELEASCEVLKISHLEMLDYADSGMMGWPTNDAPGSFWQTPVEEGAARLAELLRRYQPDVVVTYDENGFYGHPDHIQANRITMAALAMTALTPKVYWTTAPRSMMQRFGEVIREFGADGQEPDPAEAAAMAEIGLPDEEITTWVDTTAFGGQKFDALAAHASQGENIFFLRMGQERFTELMGVETFVRVQDTTGAAVPENDLFAGLR
>NC_016582|11680346:11733773|11688120_11688861_+|WP_014182369.1|DBSCAN-SWA
MGLLEGKTALVTGGSTGIGLASAVRLAAEGAHVFITGRRKTELDAAVEVIGSAATAVTGDISNLADLDRLYETIRSQERGLDILFANASVASLVPLAQVTEEHFDTLFGINVRGTLFTVQKALPLLNDGASVILNGSTNVDVGDQALGVYAATKAATRSFSRTWANELKGRGIRVNTITPGPTDTPALSGLTPAPERFKQQLATRVPLGRLGRPAEIAAAVTFLASEQSSFITGSSLYVDGGLNQI
>NC_016582|11680346:11733773|11689651_11690044_+|WP_014182371.1|DBSCAN-SWA
MSDGDLRAFYLRYIEELNAHKFDGMGKFINDRTTLNGEPATRDDLIAVQKQDVDAVPDLHWELKELLFDSDRLAARLINTGTPVKEWLGVAPTGASFEIVEYAIYQLRDGRFVHMTALRDAGELHRQLTG
>NC_016582|11680346:11733773|11692682_11693546_-|WP_063647590.1|DBSCAN-SWA
MPRWRSAVNFFDTAIRSQAVAEVPGAEGVGVVAQTGEGVHDFAPGDRVAWLTINTHGSYAEQIVLPANGAVPVPDAIDDETAAALLLQGLTADHFATASHPVRPGAVALVHAAAGGVGMMLTQIVKARGGTVIGLVSRPEKVKWATDAGADHVLVSTGDAFVGPVRELTGGEGVHVVFDGAGASTFAASLQVLRTHGTMVFYGPLIGDVPTIAMNDIPRSTRLTYGVTEDHIRTPEELRARTAELFTLAEKGELVVRIGGRYPLAEAAKAHADIESRTTTGKLLLIP
>NC_016582|11680346:11733773|11731772_11732531_+|WP_014182421.1|DBSCAN-SWA
MRDRLSGQIALVTGATGGIGAAVSRRLATEGATVVVTDVDAGRCDRLAAELTADGARALGLALDVSDEEAWRGAVERVVSAWGGLSVLVNNAGIAEMRTVETETQESWDKVIAVTQGGVWLGMKHGGPAIERSGGGSIVNIASIFGTVGGFGSQFSYHAAKGAVRLMTKNAALHWATRGVRVNSIHPGFIETPLSRELWRGTPRHTAMVEGTPMRRLGRPEEVAGAVAFLASQDASFVTGSELYVDGGWTAR
>NC_016582|11680346:11733773|11720491_11721637_-|WP_014182410.1|DBSCAN-SWA
MSTDVLICGAGRTPFGRSEATGRQLAVGAVNAALADAGIEWSRVRAAFGGSDSAGLADTLVAQLGLTGLPFVNVKNGCATGGSALVCAVNAIRSGMADVVLAVGFDKHPRGAFDPRPEDWGLGSEYGSDGLMVTTQFFGMKIQRYMHDHGITPRTLALVAEKAYRNGALTPEAWRRTPLSAEEILDSGMVSDPLTRYMFCSPGAGAAALVLCSPEAARTMDGPPVTLRSAAVRTRRFGSFEVFSPWIPGGEPTSVSRDASAAAFEEAGIGPGDVDICQLQDTESGAEVMHMAECGFCQDGEQERLVASGGTGIGGTLPVNTDGGCIANGEPIGASGLRQVYEVVQQLRGRAGERQVPGEPRVGFTHVYGAPGVSACTVLSR
>NC_016582|11680346:11733773|11733425_11733773_-|WP_014182424.1|transposase|DBSCAN-SWA
MSLRPVPVPETPETTARVARAAFPKGCLAMRVRNELGVLFQDADFAAAFPARGGPGLAPGMPAMVSVMQFAEQLTDRQAADAVRSRIDWKYLLGLELEDPGFPLLRPLRLPDTPG
>NC_016582|11680346:11733773|11683966_11684236_-|WP_107425963.1|DBSCAN-SWA
MAQEGSISAGARRQGVTQPAMTPGARHRTVADDTHGRQVPRPPIEPPTVSGHCAISGGVWHSYYDATDVSNARVLGIDHLVNARTTPMT
>NC_016582|11680346:11733773|11706859_11707954_+|WP_014182395.1|DBSCAN-SWA
MGAGTEPDGSSRSDEEWERFLRESVAGAADAPKEPSARARDVAKRLRAEPGRDPEGWRSYTPARPKRRTGWYVVGLLASLVLLVVALAPGPIVDLFAGTTDSPPQAAETARPTQAPPAEAAQQPTVEEPFRGSPAASWASGAAGITVPKAGAVGWMSAAEVKRALARSRDFLVASGLDRGVLRGERPEKAIALINPHQKDVQDLLKTAFRTPSEKNDPLLLFSRFQPSRTHLVGDVVKTRGRLTYREGERGALQVTADVTFVYPVTRADAGGDEIVRTIVRRELVLSWDDPDKVITEPGTFSIVSYKYDMTNGGCGAPTGYFIPPFGTDRPADEAGTEVDPYDRSTPVGQGKSSGDECRRATRS
>NC_016582|11680346:11733773|11719257_11720460_-|WP_014182409.1|DBSCAN-SWA
MSGIPGPKEFRAQARQWLAGVGRPRAADGEWGSGSDSVAVFENWTEEQEREHTARVQEWERTRYDQGWSALDWEETYGGRGLPAYYEQLYRAEEAAFDVPHRTEIFPVTQALVAPAVGIWGTEEQKRRWLRPMLRTDELACQLFSETEAGSDLAAVRTKAVREGDDWVLTGHKVWTSGARVATWGVAVCRTDPEVRKHAGITVFLVRMDAPGVTVRPIRQMTGGTSFNEVYLDGVTVPDTDRLGPVGEGWRVTLSVLAAERLDSGGLGLDNADRALELAGHLPRPLTGSEQQRAADLHIRTLVQRLIGLRVTAALVAGREPGAEASVGKLYATETMRRTSDLVSELLGPSLVADTGAWGSFAWTEHLLGAPGYSIAGGTDEIQRNILAERVLGLPKEPVR
>NC_016582|11680346:11733773|11702290_11703355_+|WP_014182390.1|integrase|DBSCAN-SWA
MAEARLQVIAGGVVPQEPLTTDPWQFQAACVDAFVASWRARGFSPVTIDNDIGLLERALAALGRPAWEVTPEDIDRVVGDLAVKGRATSTRREYVQIFKGFHRFLQARKAAEIEAAFGARLVCPVDEFNASRHVGDDSPALVPPPTPERVTEFFDFMKQRIATARKYGPAARDYALFRTLYHAGLRSEEASLLEKPDAHFSRGPFGKLHVRFGKGAHTSGPRPRWVPMLDGLDLVLRWFLEDVRPKFPDSPVLFADESGGSLHRGTIRNRLRYLMELEGRPTAERFSPHALRRACATHNYERGVDLVAIQQMLGHWTVSSTMRYVRPSATFIEDAYQRAVAGTLAELTEKDTTA
>NC_016582|11680346:11733773|11696191_11697205_-|WP_014182379.1|DBSCAN-SWA
MLIAQRPSLTEEVVDAYRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPAAAVTSIRIDGVLHEFTTVPGVREDITDLILNLKQLVVSSEHDEPVVMYLRKQGPGLATAADIAPPAGVEVHNPDLVLATLNAKGKLEIELTVERGRGYVSAVQNTQQGQEIGRIPVDSIYSPVLKVTYKVEATRVEQRTDFDKLIVDVETKPAMHPRDAIASAGKTLVELFGLARGLNIDAEGIDIGPSPTDTALASDLALPIEELELTVRSYNCLKREGVHSVGELVARSEADLLDIRNFGAKSIDEVKAKLAGMGLAFKDSPPGFDPIAAADAFGAGDAGFVETEQY
>NC_016582|11680346:11733773|11708234_11708549_-|WP_014182396.1|DBSCAN-SWA
MAVEGQGFVFAKIVVRDLDAQLAFYSEVLGQVVKHRVSGCAGEHAFEEVVMGSTDGDGPVDHLRVIPPPATTPAADRQERPQPFPLGVRQITPPHVHINNPKAQ
>NC_016582|11680346:11733773|11703681_11705322_+|WP_043488361.1|integrase|DBSCAN-SWA
MGKRQRDCVSCGGPVGYRDRLYCCRCWRQLKEQTTKASCPSCGKDRVLQADTGRCITCSRVCDQCGHPVRAAVNRLCRDCRRKAERLAAQQPCPRCGKLGYVREDTGWCGSCSRPGPPKQPPQVCRECGRLRRHAGLGLCSACWQRHPGRPFIRGDNLREVLADPPVWLADYVAHVAARFCVARACGLVTDLGRLLNDEHSNSPQALLERSRRPGRSMGSFARALEDFFTLRGLALPTDQAERLAAGRRQRRIDAVPVPLRLAVTAFDASRMRAQDRARRAGTRPRSDHTLETALSILRDLACFLVEQRGKDDWALADVHDVETFLATVPKARKRRLVVLRQFFRFARSNHLVLVDPTRTLIVKEPNGFRGRTLTLDQQRELFRRWTTDKRVHPHEALLGMLALLHGASSTEVRQLQIADIDAAAQTVRLGKRPHPVPLDPASWTVLQRCLAHREAWPTTNPHVMVTKGTKAGRNPASTAYLSHVLDDCGHPPRTIRSTRLLGLVNTLDPKLVAAAFGMDPQATLIYLADRVDEGRLPASEPSRKR
>NC_016582|11680346:11733773|11711811_11712189_-|WP_014182400.1|DBSCAN-SWA
MTGTPTAAPFLTAWFEILDGDEPSRILDLISDDFSLSILFSTGDGNATDFAGDRAALVGYLEQRERGTRTHHLLSATTLGQDELFLGEVRRAGVPEASFVAAGRVNGEGRLQRLLIGRSSEIRFT
>NC_016582|11680346:11733773|11695351_11695573_-|WP_014182377.1|DBSCAN-SWA
MTKRPALRRHLSTSPFKAPVAPLAKHFALGERVSHDRYGLGKVIGVEDKTAMLVDFGSHEVRIVSPYTGLHKL
>NC_016582|11680346:11733773|11726430_11727180_+|WP_014182416.1|DBSCAN-SWA
MRFDKKVAIVTGGARGMGASHVRGLAAEGARVAVCDLLDDEGEALADELPHTRYCHLDVTDEAQWQSVVRTVEDTFGPVDVLVNNAGIIHFGGVVEQSPEHFRRILDVNLVGAFIGMHTVLPGMRDRGHGAVVNVSSAAGLVGFAGGIGYVASKWGVRGMTKAAALDMAGTGVRINSVHPGVIRTPMGEDASPGLFAHQPVPRIGEPEEVTRMVLFLASDDASYTTGGEFLVDGGQTIGHSSHSPTTGD
>NC_016582|11680346:11733773|11701540_11701705_-|WP_014182387.1|DBSCAN-SWA
MDDWTVKPKSGFCLITDQGNVVRPEITRFVGGGPDLIWDPPERIEFAATMWQAS
>NC_016582|11680346:11733773|11725332_11726373_+|WP_043492847.1|DBSCAN-SWA
MRALRLTAWGEPPAPAEVERPTPRGTEVLVQVEAAGLCRSDLHVIDGAPGSLPYRLPFTLGHEVAGRAAALGPDADGVAVGERVVLYGPWGCGACDRCATGRDNYCDRRDTLTWHGAGLGRDGGMAEYLLVPSARHLVPIGDLPADQAAPLSDAGLTSYHAVAGLRHALREGTSTVVIGVGGLGHLAVQILRATTTSRVLAVDVREDALALADRSGADFGTLMRPDTARVLRARTGDAGADAVLDFVGTAKTLELATGVLRPGGELAFVGSGGGCLTVSKPGVLPPGFRLSLPFWGTRPELAEVVTLARSGALHVESERFPLSAAPEAIGRLRRGQVRGRTVLVPD
>NC_016582|11680346:11733773|11708721_11709762_-|WP_014182397.1|DBSCAN-SWA
MTTRFGQGPWAASGIQTVQPGVHRVPLPLPGDGLHAVNVYLLEDLADDGGIVMIDGGWAIPEARKALEEALGAIDRDPLDISHILVTHIHRDHYTHAVELRRSLGSRVYLGAGERPGLEMLDRLRSDQPVGSLRTLRAAGAGELADRIEAMDHGGYDPRVWEAPDRWLDAGTLRFGDRELRVVPTPGHTKGHVVFLDEQRGLLFSGDHVLPHITPSIGFELAEPGGRPLADYLNSLRLMTRYADARLLPAHGPVADSAHTRVAELLVHHDERLARSLAALGEDTLDAHEVAHKLAWTRRAVPFGELSAFNQMLAVNETAAHLDVLVLRGRATVAFAGGVNQYTRVR
>NC_016582|11680346:11733773|11683152_11683779_+|WP_078610819.1|DBSCAN-SWA
MESERTGLDCSEDLALATYHAEWLRLWEKTLKPTTFAHYRDHVHTDLIPSFGRLPLTDLRARNITAWSEAELARGRGRTAVYRIGATFSSALSHAVRTRDQVGIIERCGHRTWRHGRMHPGDAPPNWSSRSLENSYFPRSECISAFMSGHWTNRHPVDRGLGLIDAGTAQWVSRPNQGPRETSACTRIAGDWTASAVLICRMAWSCRA
>NC_016582|11680346:11733773|11680346_11680619_-|WP_086013703.1|transposase|DBSCAN-SWA
MRSSLHCSMIQTCRREFLDRTLIGNQRHLLHALQEFEPFYNEHRPHQGIANTRPLHPLPAPIHDPDKSTHLDIRRRDRLSGLLHEYHHAA
>NC_016582|11680346:11733773|11730717_11731743_+|WP_014182420.1|DBSCAN-SWA
MTTSETPVAGVDVAALRRYFERHVPECAGPLKVTPLHGGRSNLTYEVTDGTRRWVLRRPPLGVLTPTAHDMDREHRVVAALGGTGVPVARAVLSCTDPEVIGAPFCVVGFVEGTVLRDGDKAAALPPDDARRATDALVDALVTLHSVDAAAVGLGKFGRPDGYLERQVRRWRGQWDNVATRPLPDLDELHGRLARALPESGTPAIVHGDYRLDNTILAPDFGRIAAVVDWEMATLGDPLADLGMLLMYWDRTCEPVLGARHVPTANPGFPSGPELAERYAEKSGRDIGLLPYYQAMACFKLAVIAEGIHARYRAGQTVGTGFERVGSAVPALLGSGLELLP
>NC_016582|11680346:11733773|11690804_11691230_+|WP_043488359.1|DBSCAN-SWA
MNDETLAQRHETVREYFRRVDRGDPGFADICTDDIEFYFPKFGFGHGQDAIAELARRLDLEHLEHDIEGLDIMTSGDRVIVEGREWGTTRDGHAWPDGEISRGLFCNVFTFQGHLISKLHVYTDPDFTSSHQEKVRQLHRG
>NC_016582|11680346:11733773|11727217_11728528_-|WP_014182417.1|DBSCAN-SWA
MSTTQQPAPPGSESAPYAPRTVRRAMLAGSIGTLIEYYDFSVYGYLAVAIAPQFFPSDDPAASTLAALAVFATGLVVRPVGGVFFGWIGDRWGRRKALVSSVLCMGVASSITGLLPTYSQIGVVAAVLLFLTRLVQGVSSGGESVGAYTYIYESAPPRRRAFLGAVTPIGSNLGFMFAAATAGAISALTTKEQMADWGWRLPFLMAVPLTLVCLWARLRIEDTPEFEEAARRADIPAAPIREVLSTHRVALLQSIGLAMAQGGAIFLGLTYIGIYLSTKLGYDPTLVFWLSAGVVLVTVLLMVPAGWLAARFGCRRVLMGGLLGFLVTAYPAMMLMGRHSLALAGLAYLLFMLSSAFVQVPAASLWPHLFERRVRYTGMAIGYNIGTVLAGGTAPYIAAFLVERTGNLLSPAFFVMVVCLIGIGVLFTVRTDVTDV
>NC_016582|11680346:11733773|11712786_11713410_-|WP_014182402.1|DBSCAN-SWA
MATRIVEPEAGPRSKRAAILAAAVDCFGETGFEATKWSIVAERVGIGQTALYHYFESKTHCLLTIMRLELKRSHDKFTETTADVTDPVEALRAAVRAAYDVSDHEVLQMRILHNHMDLLAGPRKSKREEAERVEARRLVQLVERDWTNLLVRGMSMGVFPLRDAQLLGAGVLGLIVSVWRWYRPSGPTPLSEISELIEGACVRMVAT
>NC_016582|11680346:11733773|11717018_11718260_-|WP_043488365.1|DBSCAN-SWA
MDFGFSPRASELLGRMRSFMDSYVFPAEGVYDRQLTEAHDPHALPPVMAELKEKARAEGLWNLFMAHGDWGAGLSNLEYAPLAELAGRSVIGPEVFNCSAPDTGNMELLALYGTPEQQERWLRPLLEAEIRSCFAMTEPEVASSDARNIRTRITRDGDVYVVNGRKWYTSGILDPDCKLIILMGKTDPKAPTYRQQSMLLIPRDTPGVTVLRDLPMFGYTDRLGHGDVLFEDVRVPVENILGGEGEGFALAQGRLGPGRMHYAMRAVGFAERALRLMCERVTERVAFGAPLADRGVVREWIARSRIEIEQVRLLVLKSAWLMDTVGNAAARMEVAAIKVAALEVAHKVVDRAVQAHGAAGVSDDTVLARLYAITRALQIADGPDEVHLRTVARQELARYEKTGTKTDTKAGAV
>NC_016582|11680346:11733773|11722997_11723861_+|WP_014182413.1|DBSCAN-SWA
MPRISRLGIVGCGLMGSGIAEVAALRGLDVTVAESTPELAAAGRARITASLHRGLRRGKLTESDRDQALARLSFTHDLGELADRQFVVEAVAENREVKLEVFRRLDKVVTDPEAVLATNTSSIPVVDLAVATGRASHVVGLHFFTPVPVQKLVEVIPALTTGAETLARTRDFAAERLGRTVIQAPDRSGFVVNALLVPYLLSAIRMVESGMARADDIDSGMELGCAHPMGPLRLLDLIGLDTAQAVAESMYEEFKEPLYAAPPLLRRMVAAGHLGRKSGRGFYVYDG
>NC_016582|11680346:11733773|11711433_11711754_-|WP_014182399.1|DBSCAN-SWA
MYNLVLLAARPPEWTHERFIAWWRGDHAELTCRLPGLRAWRHTEIDAALEPRSEGWDGISVLGFDSPEDLKKALASPEWADAVAQVGDMKGRRVAVMGHEAEMFTA
>NC_016582|11680346:11733773|11714678_11715473_-|WP_043492842.1|DBSCAN-SWA
MRVGIEIDDGGLARVTLRRGEAGNAIDLDMARGLLDAARTCAAEAVRAVLLTGEGKSFCVGGDLREFSRLSGEALHQHLTTVTAALHDALRTFAASDAPVVAAVQGAIAGAGIGLAASADVTLAAADASFTAAYTGIGYSPDAGVSWFLPRLIGPKRALDLLLTNRRIPAAEAADIGLVSRVVAADRLAAEAARTAEALRRGPTAAFGATRRLVAAGLTADLGPHLDREARAIAAAAASDAGREGVAAFLGKRTPDFTRVALKP
>NC_016582|11680346:11733773|11685934_11686420_-|WP_086859518.1|transposase|DBSCAN-SWA
MLGRIPDPHQVRGRRYRLGSLLALCLLAVLGGAKPLAAIARFAAATDSELRERLGPASTTPDAFTLGRLPARLDGDALHPCQTVIAQRQVAAKSNEIPAFAPLPERIDLHGVVVTADATAPAARCSLAPARLRDQADHQTGERPVRRSGETPAEHHQHSGK
>NC_016582|11680346:11733773|11698665_11698869_-|WP_014182381.1|DBSCAN-SWA
MTSHPAQETIARRKAIPAREDGFLDGSEQLLLIYNRWVCERGIKAVPASLLRSKMEEAYRIRLRLNS
>NC_016582|11680346:11733773|11699816_11700047_+|WP_043488360.1|bacteriocin|DBSCAN-SWA
MSAAGMSRAEAVALVQRIMDADYASEEEADSWLDTLDRALACPAGHVSGLIFWPPERELSADEVVDHSLAYRPIAL
>NC_016582|11680346:11733773|11687418_11688027_-|WP_014182368.1|DBSCAN-SWA
METKQTGPIGRPRGFDADEALERAMLVFWKHGYEGASTACLTNAMGISTTSMYAAFGNKEKLFRKALERYTEGPSAYLARAMEEPTALGVATAILAGTVRTTTRPAHPHGCLGVQSALTTSDSGQEVRDLLVAWRQNGHSCIRERFQRAVDDGDLPPQTDPGLLARYLTTFAYGIAVQAASGVGRDELQEMADAALRNWPLF
>NC_016582|11680346:11733773|11718286_11719261_-|WP_014182408.1|DBSCAN-SWA
MNTATQAPEPAARVRDRLARRHPGALIGELTVLPGGHSGLTYSVAAGGARYVVKAVPPGQRPVGRNDVLRQARVLRALAGSAVPVPGVVAVDERPPAWFAMDFVAGEAVEPVLDENEVPAATARARMLEIASVLRRLHDTDADTPGLDAPEPLDPVGELERWSRTLHAVPAELRPGGQELLARLADDVPRGLPPALLHGDFRLGNVLCAGERAVAVIDWEIWSVGDPRIDLGWFLLFADHHNFPELGHAVPGLPGEAELLDAYRDDRPAPPAMDWFRALGRMKMAAIMGHNLRRHREGKHHDPDQERLPPTIAAMIRTARDILG
>NC_016582|11680346:11733773|11693811_11694279_-|WP_014182376.1|DBSCAN-SWA
MTSNAELSFRIMGASARWTTALAALAAIGAGVAAGLGVPGHDQWVGCSSVLAVGTLTAFGFLRRRLEAGQDGLRYRTVLRWHRLEWDEIDRFEDVRVQPGDRRLSTHNLRVVAKLRSGEVVWLPAPYAGSVDAFSFEDQLRALRAAHHHYRPGTP
>NC_016582|11680346:11733773|11690110_11690797_+|WP_014182372.1|DBSCAN-SWA
MTVTLITGANKGIGFETAKQLLELGHVVYIGARDAERGEKAAAALGARFVQLDVTDDASVKSALATIDSAEGRLDILVNNAGILADGVLDGPTALRAFDTNAVGIVRVTEAALPLLRKSSAPTVVTVSSSAGSFWAVTNPDRPEFNLPLALYSASKSAATMLTVQYAKSQPGIRFNAVEPGTTATDLTAAFGIGRTPEESARVVVRLATLDADGPTGTFQDENGEVPW
>NC_016582|11680346:11733773|11729518_11730721_+|WP_055414373.1|DBSCAN-SWA
MSIGFEIDERVAEIARRTTEFVRDVVISEEQACDGNVHAGPEPLRRRLQGAAREARVFAPHVGAKWGGLGLDLCGQAVVFEAAGYSLLGPLALNCAAPDEGNAHLLEVVATEQQQERYLRPLAAGEVRSCFAMTEPAPGAGSDPRALTTTATKTDGGWRIDGRKWFISGADGAAFAICMARTCGGPGDAGGATMFLVDADNPGMKIVRNIDTLDQGLFGGHSEIVFEGCEVEDTAVLGEVDQGFAYAQVRLGPARMTHCMRWLGVARRAQDIALERAADRSAFGKPLAELGMVQQLLADSEIDIETGRAVLWRACWELDQGRPAAQHTSIAKTYVSEAVNRVVDRAVQICGALGISGDTPLSRLYREVRPFRIYDGPSETHRWAIAKRAVRAARERRAIR
>NC_016582|11680346:11733773|11733101_11733269_-|WP_158104660.1|DBSCAN-SWA
MRARGPGGRRRDWLRAARIADVSWQERYGQRADSYRLPMGDVERGAFAVQVGVDG
>NC_016582|11680346:11733773|11723954_11725100_-|WP_014182414.1|DBSCAN-SWA
MHRRHPEIDPQLLSESDEQRQLRTVLRDLFTEASGAEDVRKHLATARGYDEALWVRLAGEIGVHGLAVPEEYGGSGFTFAELAVALEESGRALYCAPLLPTVVLAAHALLYSADRTACERYLPRIADGTLTATVAGFGADEPGVTAEQEGKGWVLRGRADFVLDGAGADLIVVRAGTPAGPRLFACEPASGACRRTPRRVLDETRRQALVEFRGAPATAVGMAEGAEDTVSATLDAGRAALAAEQVGGSGHALDATVEFAAQRHQFGRPIGSFQAVKHRLADVLVALEAARSASAYATACAAVASPQLPVAACAAAVVCSETFRLATAEYVQLHGGIGFTWEHPAHLYMRRARGGEVLFGTADRHRVRLAGLIGLATRAAA
>NC_016582|11680346:11733773|11721633_11722014_-|WP_043492845.1|DBSCAN-SWA
MATDPRSPAAGLQGSRCSGCSVAVYPADDACPRCGGPARPAALQGTGTLWTWTVQRYAPKSPPYRAPAGGFVPFALGYVELAEGVRVAAVLDVDDFEDLRIGMPLTVTAGAGVPRARPTTPGEEGS
>NC_016582|11680346:11733773|11722019_11722808_-|WP_043488367.1|DBSCAN-SWA
MTVEDEIQFERDGHVARVWLNRPWKKNCVTVPILDRLDEIITEVDEDPGLRVLVVRGRGGTFCSGFDLDSLKADYVGKSNAIDVAVKSAKVCDRLYSMKTPSVAVLEGHVTAGGFEIMISCDFAISADDAKIGDFHIRRALFGGAGPIYRVPRMIGIRKTKELMLTGKLLSGVEAAEFGLINKSAPADKLDETVEDFIGDLADKSPFTMWLTKMTIDRSLDADTQSLMVMEHLAVGVALNSEDANEGVSAFLEKREPKWQGR
>NC_016582|11680346:11733773|11715469_11716249_-|WP_014182405.1|DBSCAN-SWA
MTAPRPAAELFSLQGRTALVTGASAGLGARFAAVLARAGATVFAAARRVDRLKELADGGERIHPVACDVSLSADRTRLARTARAATGRIDILVNNAATSGETRAEDESPGAFADVLGVNLTAPFHLARLVAEAPAGDHAPSRSVINVSSILGLVTAAPLGGASYAASKAGLIGLTRELAGQWGPEGTRVNALAPGWFRTEMTADLFGDERSSRWVERNTLLRRGGGEHELDGALLFLASDASSYCTGQVLTVDGGWTAR
>NC_016582|11680346:11733773|11709841_11711359_-|WP_043488363.1|DBSCAN-SWA
MRQVVREFQQRADEADFVAVIDDFGSHTARQLLDEATRLAGALSAGTADGAVGTVLVQADNSWRTVAATLAVGLAGGDGGVIALINRHTTAAEFTAAWEDIRPDAVVAEASAMDEWAVRTRLPGPARTVLDGWTCLSTPHRREVSRWSGGVLIGLTSGSTGRAKGVVQSERALRYAATSTITVNGLSPGDAVAAIVPLSSTAAYCFGVYLSLLLRGPLVMTGKWDRAVALRRMADTGVRWTMCVPTMALQMGAEAAGSGILRGVRSITVGGGPMDRGALARAERSLGTKILRVFGMSECLGHTSPSPDDAEEIRLGRDGRPFPGTDLHALTPDGQVAGTGLTGRAHVRGPSLFLGYARDGKADPPTLTEDGYLSTGDLLMAHEDGTVTIMGREKDIIIRGGRNIDITEIERAVAGHPRVARVCVTPVPDDVLGERVALLVVTEDGGGIDLAEVTGHLESAGLSKTKWPEYVYGIEELPQTKVGKLDRGGARDLAVRLHARGTDRP

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_086013703.1|11680346_11680619_-|transposase	transposase	NA	NA	NA	NA
WP_043488355.1|11681247_11682081_-	PIG-L family deacetylase	NA	NA	NA	NA
WP_078610819.1|11683152_11683779_+	hypothetical protein	NA	NA	NA	NA
WP_107425963.1|11683966_11684236_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_014182366.1|11684594_11685488_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_086859518.1|11685934_11686420_-|transposase	transposase family protein	NA	NA	NA	NA
WP_014182368.1|11687418_11688027_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_014182369.1|11688120_11688861_+	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	1.8e-20	32.5
WP_014182370.1|11688876_11689536_+	NAD(P)-binding domain-containing protein	NA	NA	NA	NA
WP_014182371.1|11689651_11690044_+	ester cyclase	NA	NA	NA	NA
WP_014182372.1|11690110_11690797_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
11690337:11690355	attL	NA	NA	NA	NA
WP_043488359.1|11690804_11691230_+	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_063647590.1|11692682_11693546_-	quinone oxidoreductase	NA	NA	NA	NA
WP_162097959.1|11693508_11693811_+	hypothetical protein	NA	NA	NA	NA
WP_014182376.1|11693811_11694279_-	PH domain-containing protein	NA	NA	NA	NA
WP_014182377.1|11695351_11695573_-	hypothetical protein	NA	NA	NA	NA
WP_014182378.1|11695742_11696048_-	hypothetical protein	NA	NA	NA	NA
WP_014182379.1|11696191_11697205_-	DNA-directed RNA polymerase subunit alpha	NA	NA	NA	NA
WP_014182380.1|11697369_11697867_-	SET domain-containing protein-lysine N-methyltransferase	NA	NA	NA	NA
WP_014182381.1|11698665_11698869_-	hypothetical protein	NA	NA	NA	NA
WP_143675769.1|11699131_11699668_-	hypothetical protein	NA	NA	NA	NA
WP_043488360.1|11699816_11700047_+|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_014182385.1|11700227_11700920_-	DUF4232 domain-containing protein	NA	NA	NA	NA
WP_014182387.1|11701540_11701705_-	hypothetical protein	NA	NA	NA	NA
WP_014182390.1|11702290_11703355_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_014182391.1|11703351_11703666_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_043488361.1|11703681_11705322_+|integrase	site-specific integrase	NA	NA	NA	NA
WP_014182394.1|11706445_11706625_-	hypothetical protein	NA	NA	NA	NA
WP_014182395.1|11706859_11707954_+	hypothetical protein	NA	NA	NA	NA
WP_014182396.1|11708234_11708549_-	hypothetical protein	NA	NA	NA	NA
WP_014182397.1|11708721_11709762_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_043488363.1|11709841_11711359_-	acyl--CoA ligase	NA	NA	NA	NA
WP_014182399.1|11711433_11711754_-	EthD family reductase	NA	NA	NA	NA
WP_014182400.1|11711811_11712189_-	hypothetical protein	NA	NA	NA	NA
WP_014182401.1|11712185_11712560_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_014182402.1|11712786_11713410_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_014182403.1|11713501_11714650_-	acetyl-CoA C-acetyltransferase	NA	NA	NA	NA
WP_043492842.1|11714678_11715473_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_014182405.1|11715469_11716249_-	SDR family oxidoreductase	A0A167REC2	Powai_lake_megavirus	3.8e-05	33.9
WP_014182406.1|11716245_11717022_-	SDR family oxidoreductase	A0A0M4JSW6	Mollivirus	5.3e-07	33.1
WP_043488365.1|11717018_11718260_-	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_014182408.1|11718286_11719261_-	phosphotransferase family protein	NA	NA	NA	NA
WP_014182409.1|11719257_11720460_-	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_014182410.1|11720491_11721637_-	thiolase family protein	NA	NA	NA	NA
WP_043492845.1|11721633_11722014_-	OB-fold domain-containing protein	NA	NA	NA	NA
WP_043488367.1|11722019_11722808_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_014182413.1|11722997_11723861_+	3-hydroxybutyryl-CoA dehydrogenase	NA	NA	NA	NA
WP_014182414.1|11723954_11725100_-	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_043492847.1|11725332_11726373_+	NAD(P)-dependent alcohol dehydrogenase	A0A0G2YAX3	Acanthamoeba_polyphaga_mimivirus	2.1e-11	28.9
WP_014182416.1|11726430_11727180_+	SDR family oxidoreductase	NA	NA	NA	NA
11726672:11726690	attR	NA	NA	NA	NA
WP_014182417.1|11727217_11728528_-	MFS transporter	NA	NA	NA	NA
WP_014182418.1|11728716_11729385_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_055414373.1|11729518_11730721_+	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_014182420.1|11730717_11731743_+	phosphotransferase family protein	NA	NA	NA	NA
WP_014182421.1|11731772_11732531_+	SDR family oxidoreductase	J2YAV6	Acanthamoeba_polyphaga_lentillevirus	1.3e-05	30.9
WP_158104660.1|11733101_11733269_-	hypothetical protein	NA	NA	NA	NA
WP_014182424.1|11733425_11733773_-|transposase	IS5 family transposase	NA	NA	NA	NA