CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014151	Cellulomonas flavigena DSM 20109, complete sequence	6 crisprs	csa3,cas3,DEDDh,DinG,WYL,cas4	2	2	0	0

Cas Category Instructions

Results visualization

1. NC_014151

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CRISPR-Cas detection and classification

Crispr_ID: NC_014151_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014151_1

493329-493402

Orphan

Consensus_repeat	Method
GGGCTGGATCGACGTCTCGCGCCC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_014151_1

>merge|NC_014151|1|493329-493402|CRISPRCasFinder
GGGCTGGATCGACGTCTCGCGCCCACGGGGGAGTGGGGGTGGGGTGGGGCGGGCTGGATCGACGTCTCGCGCCC

>NC_014151|1|1|493329-493402|CRISPRCasFinder
GGGCTGGATCGACGTCTCGCGCCC	ACGGGGGAGTGGGGGTGGGGTGGGGC
GGGCTGGATCGACGTCTCGCGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014151.1\|WP_013115712.1\|494617_494776_+\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_043599543.1\|496227_496413_+\|CDGSH-iron-sulfur-domain-containing-protein	unknown	unknown	gnl\|CDD\|378163
NC_014151.1\|WP_013115706.1\|488125_490258_-\|ATPase-AAA	unknown	unknown	gnl\|CDD\|226482
NC_014151.1\|WP_148234447.1\|492265_492667_+\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|372817
NC_014151.1\|WP_013115720.1\|500615_502244_+\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NC_014151.1\|WP_043599542.1\|486120_487800_-\|ricin-type-beta-trefoil-lectin-domain-protein	unknown	unknown	gnl\|CDD\|269893
NC_014151.1\|WP_013115708.1\|491054_492224_-\|pyruvate,-phosphate-dikinase	unknown	unknown	gnl\|CDD\|235809
NC_014151.1\|WP_013115711.1\|493492_494521_-\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|234599
NC_014151.1\|WP_013115716.1\|496483_497053_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223508
NC_014151.1\|WP_013115704.1\|484267_486124_-\|family-43-glycosylhydrolase	unknown	unknown	gnl\|CDD\|350130
NC_014151.1\|WP_013115703.1\|483290_484187_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NC_014151.1\|WP_013115719.1\|499969_500374_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_014151.1\|WP_013115717.1\|497324_499286_+\|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379079
NC_014151.1\|WP_148234448.1\|495169_496183_+\|iron-containing-redox-enzyme-family-protein	unknown	unknown	gnl\|CDD\|379634
NC_014151.1\|WP_043598715.1\|482283_482652_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|369571
NC_014151.1\|WP_013115710.1\|492663_493287_+\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_013115713.1\|494772_494925_+\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_013115707.1\|490449_491046_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NC_014151.1\|WP_013115718.1\|499352_499973_-\|isoprenylcysteine-carboxylmethyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224931
NC_014151.1\|WP_013115702.1\|482690_483143_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014151.1\|WP_043599543.1\|496227_496413_+\|CDGSH-iron-sulfur-domain-containing-protein	gnl\|CDD\|378163	pfam09360, zf-CDGSH, Iron-binding zinc finger CDGSH type. The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.	3.72763e-17
NC_014151.1\|WP_013115706.1\|488125_490258_-\|ATPase-AAA	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	3.99154e-33
NC_014151.1\|WP_148234447.1\|492265_492667_+\|DNA-binding-protein	gnl\|CDD\|372817	pfam13921, Myb_DNA-bind_6, Myb-like DNA-binding domain. This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.	0.000388328
NC_014151.1\|WP_013115720.1\|500615_502244_+\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	3.10644e-128
NC_014151.1\|WP_043599542.1\|486120_487800_-\|ricin-type-beta-trefoil-lectin-domain-protein	gnl\|CDD\|269893	cd14792, GH27, glycosyl hydrolase family 27 (GH27). GH27 enzymes occur in eukaryotes, prokaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-N-acetylgalactosaminidase, and 3-alpha-isomalto-dextranase. All GH27 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH27 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.	4.69059e-126
NC_014151.1\|WP_013115708.1\|491054_492224_-\|pyruvate,-phosphate-dikinase	gnl\|CDD\|235809	PRK06464, PRK06464, phosphoenolpyruvate synthase; Validated.	1.7559e-84
NC_014151.1\|WP_013115711.1\|493492_494521_-\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|234599	PRK00052, PRK00052, prolipoprotein diacylglyceryl transferase; Reviewed.	3.28664e-87
NC_014151.1\|WP_013115716.1\|496483_497053_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223508	COG0431, COG0431, Predicted flavoprotein [General function prediction only].	4.88314e-45
NC_014151.1\|WP_013115704.1\|484267_486124_-\|family-43-glycosylhydrolase	gnl\|CDD\|350130	cd18618, GH43_Xsa43E-like, Glycosyl hydrolase family 43, including Butyrivibrio proteoclasticus arabinofuranosidase Xsa43E. This glycosyl hydrolase family 43 (GH43) subgroup belongs to the GH43_AXH-like subgroup which includes enzymes that have been characterized with beta-xylosidase (EC 3.2.1.37), alpha-L-arabinofuranosidase (EC 3.2.1.55), alpha-1,2-L-arabinofuranosidase 43A (arabinan-specific; EC 3.2.1.-), endo-alpha-L-arabinanase as well as arabinoxylan arabinofuranohydrolase (AXH) activities. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. AXHs specifically hydrolyze the glycosidic bond between arabinofuranosyl substituents and xylopyranosyl backbone residues of arabinoxylan. This subgroup includes Cellvibrio japonicus arabinan-specific alpha-1,2-arabinofuranosidase, CjAbf43A, which confers its specificity by a surface cleft that is complementary to the helical backbone of the polysaccharide, and Butyrivibrio proteoclasticus GH43 enzyme Xsa43E, also an arabinofuranosidase, which has been shown to cleave arabinose side chains from short segments of xylan. Several of these enzymes also contain carbohydrate binding modules (CBMs) that bind cellulose or xylan. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	1.81855e-152
NC_014151.1\|WP_013115703.1\|483290_484187_+\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	2.0842e-62
NC_014151.1\|WP_013115719.1\|499969_500374_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.20029e-19
NC_014151.1\|WP_013115717.1\|497324_499286_+\|right-handed-parallel-beta-helix-repeat-containing-protein	gnl\|CDD\|379079	pfam13229, Beta_helix, Right handed beta helix region. This region contains a parallel beta helix region that shares some similarity with Pectate lyases.	4.61383e-06
NC_014151.1\|WP_148234448.1\|495169_496183_+\|iron-containing-redox-enzyme-family-protein	gnl\|CDD\|379634	pfam14518, Haem_oxygenas_2, Iron-containing redox enzyme. The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase.	2.3556e-55
NC_014151.1\|WP_043598715.1\|482283_482652_-\|cupin-domain-containing-protein	gnl\|CDD\|369571	pfam07883, Cupin_2, Cupin domain. This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).	8.38359e-17
NC_014151.1\|WP_013115707.1\|490449_491046_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	3.79507e-22
NC_014151.1\|WP_013115718.1\|499352_499973_-\|isoprenylcysteine-carboxylmethyltransferase-family-protein	gnl\|CDD\|224931	COG2020, STE14, Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones].	3.19383e-19

>NC_014151.1|WP_013115710.1|492663_493287_+|hypothetical-protein
MTTELLVLHAVRILGFADDAAVARRFALDPATTGELLLDAQASGLVDRAQFADLAGWSLTARGRARGEALLADELDRAGARATVRDVHRAFLPLNARLRQACTDWQLRPVPTDALAANDHTDAAWDVRVLDDLAAVELGLAPLAARLADVLPRFAGYDDRFAAARRRAAAGDGRWVDATDVDSCHRVWFELHEDLVATLGLDRRTET
>NC_014151.1|WP_148234447.1|492265_492667_+|DNA-binding-protein
MHYRRVDSKDQVARADQAQARREADARTHLLGLGADTLPDRPWRPAPVPPSAVDLVQYAVHRSGDLAPDDVLQALALLPAARAEVDGLEDGLLFVARSAGLTWAQIAQAMGFRSPQACQQHWARLSARRGADA
>NC_014151.1|WP_013115708.1|491054_492224_-|pyruvate,-phosphate-dikinase
MLVPLPDAVASTCGAKAAHLATLLRAGLPVPAGVVVPFARDTDATLRDDLRAALAHLGGGPVAVRSSARGEDGADASGAGQHETVLAVRGADAVLDAVRACRASLWSPRARAYREAARSPDEPAMAVLVQRLVDADVAGVAFTPDDPGEDVLVDAAWGLGVGVVGGTVTPDAYRLAADGTVTCVVADKRTRVDRSGAETVVRDVPTADRARRTLDEDDVRRIAALARRAADALGRAQDVEWALAGGVPWVLQARPVTAAPPRPPAAGRTGGAAAARPSPATLVGPLVGTPGSRGTATGPVRVVRGPADFARVRPGDVLVCPWTDPSWTPLLGVVAGVVTETGGLLSHAAIVARERGVPAVLGVTDATRRLRDGALVTLDGAAGTVVPHP
>NC_014151.1|WP_013115707.1|490449_491046_-|histidine-phosphatase-family-protein
MPTRHLYLVRHGDADAFGELTPTGRRQCELLGARLAGLPVNALWHSPLPRAVASAHVIAAHLPGVPVAPADELVDHVPHVPEPGEIPAPLRGFFDGYDAAEAAAGRALADALVARFTTPAPVETHEVLVTHGFQVAWLVRHALDAPDARWLGLNSGNAALTVIEHRDGVPPTLVVLNDMGHLPPDLRWTGFGGSAPRP
>NC_014151.1|WP_013115706.1|488125_490258_-|ATPase-AAA
MSLPVTSTFALPDARGAKADPALVADDEAHLDAVTHALRAQLDDLTERLAAARRAPAGGGTRAVERDQEVHRLTARLRLLRRFGLDLCLGRTVDTAGRRVYVGRTGLTAPDGTRLLADWRSPAAEPFFAATLAQPMGLVSRRRYRWAGGRVVDYWDEVLTPGAGVDGVAPDDQSAFLTSLGADRSARMRDVLTTIAADQDAAIRAPWRGAHVVDGGPGTGKTVVALHRAAYLLHADPHLGRRGGVLVVGPHRPYLDYVADVLPALGEEGVVTCTLRDLVPEGADARPEPDPHVAALKSTAAMVRAVEPAVAFSERPPVHDVVVETPWDDVVLTAADWAAAFAAAEPGTPHDEARDEVWEALVETVAERVGGDVPAGELRRALLRDRGLTRTFGRHWPLLDGPDVVADLWSVPAYLRLCAPWLTPDDVRALQRDDAHAWTDADLPLLDAARRRVGDPEAPRRERERAAAEEADRAYMADVVDYLAATDDSELGVMKALVQSDLRDALVDHDAVPRPAPDRLAGPFAHVVVDEAQELTDAQWQMLLARCPSRSFTVVGDRAQARAGFAESWPERLERVGLRDVEVATLTVNYRTPAEVMAAAEPVIRAAVPDANVPTSIRSTGVPVRHGGVAELEDVLDVWLAAHGGVACVIGDVDVASRDRVRVLTPTLAKGLEFDLVVLVAPGTWGDGVAATVDRYVAMTRATAQLIILT
>NC_014151.1|WP_043599542.1|486120_487800_-|ricin-type-beta-trefoil-lectin-domain-protein
MHALALALLLLASPALASPVAPAAAAPAPTVDEPAPLPPLGWNSWNTFYCNINEQMIRQTADAMVSTGLAAAGYQYVVVDDCWMQDTRGPDGNLRPHTSRFPSGMKALGDYIHSKGLKFGLYHAPREKTCDQYFNNRPGTSSNGNETRDAQLFASWGVDYVKHDWCDPRGSIQEQVDLFKRFGDALKATGRPIVYSINPNSAHDNTAPRYSGWGAFADMWRTSEDLKDAWSTGCPPSDQWCFVGITEALDVIEPMREWTRPGQYNDPDMLMVGVRGTLSPTENRAHMSMWAMLSAPLIMGNDVRNMSADVRSVLTNRDVLAIDQDPLVRQADRVRDDGDAEVWAKPLADGSAAVALLNRGNSARSISATLAEAGLPGGTASYREVWSGATGQTSDRITTTVPAHGVALYRVTPGSNPGPTPTTSPTPTPTTPPGSSFALVSAASGRCLDAPNSATTNGTRPVIWDCHGRDNQRWAADGATLRVLGRCLDAPNGASAGTAVQLYDCHGGTNQQWTTQSNGTIRGVASGLCLDVDRNLTANGTGVLLWHCTGSANQVWSRR
>NC_014151.1|WP_013115704.1|484267_486124_-|family-43-glycosylhydrolase
MNRRWRVAALAAAALLVPVALAVPAQADNPIVQTIYTADPAPLVHDGRLYVYTTHDEDGSTWFTMRDWRVFSTTDMANWTDHGSPMSLATFSWAQADAWAGQVVERDGKFFFYVPVVKRGGGQAIGVGVSDSPTGPFRDAIGRPLVDNAEIDPSVMIDDDGQAYLYYGNPNLWVARLNRDMVSLAGSPTRIQLTTAGYGSRPGNVANRPTLYEEGPWVYKRGATYYNVFAGACCSEFIGYSTAPGPTGPWTYRGVVMPAQGTSFTNHPGVIDYRGRSYFFYHSGALPGGGGFTRSVAVEQFAYGADGSIPRMNMTTAGPAQVEPLDPYVTQQAETTAWASGVETEAATEGGLNLAFISNGDWVRVKGVAFGSGAAAFSARVASATSGGRIEVRLDSASGPVVGTCTVPGTGGWQAWTTVTCPVSGATGTRDLVLRFAGGSGELFNVGSWQFTRDGGATPTPTPTPSSSPTPTPSPTTPPSGEVRIVNRASGKVMDVQWPNRDDLAVVGQYASNGQPWQRWQVVDAGGGYGTVRSVHSGKCLDVSGASTADGARLIQYTCHSNANQQFQWRSTGDGYEQLVNRSSGRCVGVVNASTADSAPLEQRTCTSAATMQWSRQR
>NC_014151.1|WP_013115703.1|483290_484187_+|sulfurtransferase
MAPALPALVSPELLRTTLEASTASVVVLDATTALAMHGDLEPYTAEPLRDAYLEGHVPGAGFVDVTHELSDTAAEQLFTLPAPEALAAAFGAVGVGDDTHVVVYDNVGNAWATRVWWLLRWLGHDAVSVLDGGLGAWRAAGLPVATGGEDDAALRATPRTLTPHVRPELLATTSQVAELSAGATPGVLVNALDPETFRGEQSVCPYPRRGRIPGSVNLPLFELLDPETGRLLPVASLRDRLQAGGVLGAERAVTYCGGGIAATVPAFAAFVVDGTEVAVYDGSLSEWTSDEARPVEVG
>NC_014151.1|WP_013115702.1|482690_483143_-|hypothetical-protein
MTDTLNGESSPSLERPPGATRLQRRGRVPRLVAGLCLTVGSLLAVLLFFQYLATYFVFFGDVEVATPDQATRYVVTATACLTLLLAGTAAAIARGRLGLSVLALVLTLAGVVVVALFPVPNDRWEREPEPRPANLGPVCYSGSDCSEGGG
>NC_014151.1|WP_043598715.1|482283_482652_-|cupin-domain-containing-protein
MTEPHQGAGPVVIPAEQLRLPGGRTLRFEGKDHGSGVSFFLVISNPGEGPALHRHPYTETWSVLEGEATIRIGDEDVVAHAGDTTVVPPDTWHAFTNTGDGDLRMMCIHASPVMLQDDHPAP
>NC_014151.1|WP_013115711.1|493492_494521_-|prolipoprotein-diacylglyceryl-transferase
MHLGIPSPDLAWSGFSLGPLTIHTYALCLLTGIAAAIWLTSRRLTARGGPPGVVEDIALWAVPFGIVGARIYHVLTHWSDYVGPGKNLVEVLYVWEGGIAILGSLIGGTVGAAIACRRAGVRLWSFADALAPAMLLAQAIGRLGNWFNHELYGAPTTLPWGLEIPPDNGAFPPDLPPDTLFHPLFLYEMLWNLLGIAVILWLERRFALRWGRAFGVYLVWYGAARVWLEMLRIDPTSVTPLGLPANVWGALAAVAAGVTLIVVQGRRHPEPETSVVVPGGPADQPQDEGADGEGGDEPAVTIEASDAAPPPASLPTGGAPAAAPTVDPGADAERTEPADDRT
>NC_014151.1|WP_013115712.1|494617_494776_+|hypothetical-protein
MSDSTTAYDPADDPDADPANLNPRTGAAAAGGADDDADTDAEPANLNPREDA
>NC_014151.1|WP_013115713.1|494772_494925_+|hypothetical-protein
MSETLPDSFDEKQPDVPSLGVDPDPLPDDHEGDAPEGADGTGSPDVPRTS
>NC_014151.1|WP_148234448.1|495169_496183_+|iron-containing-redox-enzyme-family-protein
MPLPTPRGPVSDTLLRVLAGTTEPAALHEEVAGVLAAPTGSWLEHDDVQLTLTCMYELHYRGLDGVDDDWEWQPDVLAARAELERAVEAELRERVRVDVPVDTSAGAVAQTLFALAAADDGPSMSRWIARRAQRRHLEELLVHRSLYQLKEADPHTWSVPRLGGAPKVALMEIQSDEYGAGDPERQHAALFAQAMRGLGLDDTYGRYVDHVPAITLAHPNVMSMLGLHRRLRGAIVGHLAAFEMTSSIPNRLYGNGMRRVGLGEDVTEYFDEHVEADAVHEQIAGRDMAGRLVEQDPRLGGDVMWGAAVCLALDGWWAQHVLERWEAGEPSLREPLR
>NC_014151.1|WP_043599543.1|496227_496413_+|CDGSH-iron-sulfur-domain-containing-protein
MRITPCQDGPLLVRGPVELVGADGEAIVPRRRTVALCRCGGTGTPPWCDGTHKVNGFRTQD
>NC_014151.1|WP_013115716.1|496483_497053_-|NAD(P)H-dependent-oxidoreductase
MSTYQVAYFVGSLSSTSINRTLSKALIRLAPDDLEFTEIPIGDLPLYSPDFDEDYPPEARALKDALAGADAVLFITPEYNRSIPGALKNAIDWASRPWGQNSFDHMPAAVIGASIGQIGTAVAQQSLRGVLTFCNARQMTAPEAYIWFKPEVYTEDGEVTDEDTKSFLRGFMEEFRAHVERVLTVLPRD
>NC_014151.1|WP_013115717.1|497324_499286_+|right-handed-parallel-beta-helix-repeat-containing-protein
MAQVLHVSVHGSDDAVGTQDAPLRTIDRAARLARPGDTVTVHAGTYREWVRPRRSGRGENRRITYQAAPGEHVRITGSEQVTGWESLGGGVWRVEVPNALFGEFNPFAVEVDGDWIVRPGRDEPKKHLGAVYLDGRRLHEVATADEVPDAPRREEIVDDWTGTVVPVPDPDRTPRVWHAEVGADVTTITASFGDADPNAALTEINVRPTVFWPQDHHVDFITVRGFELCQAATQWAPPTANQPGLIGPNWARGWVIEHNDIHDATCSAVSLGKEASTGDNYATDRGDKPGYQYQLESVFSARQIGWDREHIGSHVVRDNHIHHCGQNAVVGHLGCVFSRIERNHIHDIANDRAFYGHEIAGIKLHAPIDVVIADNRIHDCSLGIWLDWQTQGTRITRNVLWANSRDLFIEVSHGPYVVDHNVLTSPVSVENHSQGGAYVRNLLCGTVNLKQMLDRATPYHRAHSTDVAGYAIILTGDDRWIGNVFAGGDLDKAYHPDSWGRIGSQTGTAAYDGFPTSLEQYLTEMGDRWDGDHNRFGSRVQPYCSRGNVFAGGARPADVEVDPLVLDGTPRVEVVTQGDEVWLEVDVPGADAAVLDALTGADLPPVRLVGLEFEDVDGSPTAFDTDVAGEQLDGPHPAGPLAGGLKSARLRLL
>NC_014151.1|WP_013115718.1|499352_499973_-|isoprenylcysteine-carboxylmethyltransferase-family-protein
MTPTTAAATGLVLYLVGVVAAFGIRTWLHRRRTGSTGWRGLSGAPGSAEWWGGALFAAAIVLGAAGPALAAVGVGPAPAALPGSVAWLGLAVAVVGFLATLAAQAGMGASWRIGVDADERTDLVTTGTFALVRNPVFTAMATALVGVVLLAPTVVTLAALACLVVAVQLQVRVVEEPYLRRAHGEAYAAYAARVGRFVPGVGRARA
>NC_014151.1|WP_013115719.1|499969_500374_-|winged-helix-turn-helix-transcriptional-regulator
MTMTENGGDAAGQGLSAAACLFRAFGDPSRLTILQHLALGEHRVVDLTAHLGLAQSTVSKHLACLRDCGLVESRSEGRSSLFRLTHPAALLDVLAAAERVLVLTGDAVTLCPTTGAGTTPTSATPHDATEETPR
>NC_014151.1|WP_013115720.1|500615_502244_+|SulP-family-inorganic-anion-transporter
MPDAPRPPLPSGSGADDAPDDVAPAPRSTAAGTPAADGATHATPAPGPPEADTSHSVLAALRSPRRLRTELLAGLVVALALIPEAIAFSVIAGVDPRVGLFASFTMAVSIAFLGGRPAMISAATGAVALVVAPVAPRHGLDFLLATIVLAGVLQVLLGLLGVARLMRFVPRSVMVGFVNALAMLVFMSQVPHLTGVPFLVYPLVAAGVVVIVLLPRWTTVVPAPLVAVVLLTAATVLGALQVPTVGDEGELPESLPVLHVPDVPFTLETLRIIAPYALAVALVGLLESLLTAKLVDDVTDTHSDKTREAWGQGGANIVTGMLGGMGGCAVIGQTMMNVKISGARTRISTFLAGVFLLVLVVGLGDVVAVVPMAALVAVMIMVSVGAFDWHSVHPRTLRRMPRSETAVMLTTVLVTVVSHNLAFGVGAGVLLATLLFVRRVAHVTTVTRLDGDDDGPRVYAVEGALFFASSNDLVYRFDYAGDPQDVVIDLSKAHVWDASAVATLDAIRHKYASKGKTVTIVGTDPVSAERMVRMAGEPGGGH

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Crispr_ID: NC_014151_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014151_2

561622-561826

Orphan

Consensus_repeat	Method
GACCTGCGCGACGCCGACCTGCGCG	CRISPRCasFinder

4 spacers

The CRISPR arrays of NC_014151_2

>merge|NC_014151|2|561622-561826|CRISPRCasFinder
GACCTGGCCGACGCACCCCCGGGCGCGCGGGACCTGCGCGACGCCGACCTGCGCGGTGCGGACCTGACCGAGGCCGACCTCACGGACGTCGACCCGCGCGACGCCGACCTGCGCGACGCGGACCTGCACGGGGCGGTGCTCGCGGGCGCCGACCTGCGCGGGGCCGAGCTCGCCGGTGCCGACCTGCGCGGGGCCGAGCTCGCCG

>NC_014151|2|2|561622-561826|CRISPRCasFinder
GACCTGGCCGACGCACCCCCGGGCG	CGCGGGACCTGCGCGACGCC
GACCTGCGCGGTGCGGACCTGACCG	AGGCCGACCTCACGGACGTC
GACCCGCGCGACGCCGACCTGCGCG	ACGCGGACCTGCACGGGGCG
GTGCTCGCGGGCGCCGACCTGCGCG	GGGCCGAGCTCGCCGGTGCC
GACCTGCGCGGGGCCGAGCTCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014151.1\|WP_043598723.1\|557349_557751_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_014151.1\|WP_043599588.1\|566701_567655_-\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234993
NC_014151.1\|WP_013115772.1\|562055_562748_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NC_014151.1\|WP_013115766.1\|552652_555958_-\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_013115764.1\|549898_551020_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NC_014151.1\|WP_013115765.1\|551187_552456_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NC_014151.1\|WP_013115767.1\|555954_557280_-\|SWIM-zinc-finger-family-protein	unknown	unknown	gnl\|CDD\|309540
NC_014151.1\|WP_013115781.1\|569734_570871_+\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341462
NC_014151.1\|WP_013115762.1\|548465_548894_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|240040
NC_014151.1\|WP_013115770.1\|560441_561029_-\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_148234451.1\|565601_566606_-\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224748
NC_014151.1\|WP_013115776.1\|565097_565598_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NC_014151.1\|WP_013115763.1\|548895_549201_+\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_013115779.1\|567699_568884_-\|alanine-racemase	unknown	unknown	gnl\|CDD\|143481
NC_014151.1\|WP_013115769.1\|557885_560411_+\|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NC_014151.1\|WP_013115782.1\|570923_571376_+\|GatB/YqeY-domain-containing-protein	unknown	unknown	gnl\|CDD\|370480
NC_014151.1\|WP_013115761.1\|547037_548456_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|223727
NC_014151.1\|WP_013115774.1\|563573_564485_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|340419
NC_014151.1\|WP_043599590.1\|568880_569504_-\|dipeptidase	unknown	unknown	gnl\|CDD\|350618
NC_014151.1\|WP_085955042.1\|562895_563264_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014151.1\|WP_043598723.1\|557349_557751_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.22263e-13
NC_014151.1\|WP_013115772.1\|562055_562748_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	1.42688e-07
NC_014151.1\|WP_013115764.1\|549898_551020_+\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	1.96114e-06
NC_014151.1\|WP_013115765.1\|551187_552456_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	3.9241e-52
NC_014151.1\|WP_013115767.1\|555954_557280_-\|SWIM-zinc-finger-family-protein	gnl\|CDD\|309540	pfam04434, SWIM, SWIM zinc finger. This domain is found in bacterial, archaeal and eukaryotic proteins. It is predicted to be organized into two N-terminal beta-strands and a C-terminal alpha helix, thus possibly adopting a fold similar to that of the C2H2 zinc finger (pfam00096). SWIM is thought to be a versatile domain that can interact with DNA or proteins in different contexts.	0.000286331
NC_014151.1\|WP_013115781.1\|569734_570871_+\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341462	cd08183, Fe-ADH-like, Iron-containing alcohol dehydrogenases-like. This family contains iron-containing alcohol dehydrogenase (Fe-ADH) which catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. Its activity requires iron ions. The protein structure represents a dehydroquinate synthase-like fold and is a member of the iron-activated alcohol dehydrogenase-like family. It is distinct from other alcohol dehydrogenases which contain different protein domains. Proteins of this family have not been characterized.	8.44945e-154
NC_014151.1\|WP_013115762.1\|548465_548894_+\|NUDIX-hydrolase	gnl\|CDD\|240040	cd04684, Nudix_Hydrolase_25, Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.44172e-33
NC_014151.1\|WP_148234451.1\|565601_566606_-\|acyltransferase-family-protein	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	5.73478e-29
NC_014151.1\|WP_013115776.1\|565097_565598_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.000195623
NC_014151.1\|WP_013115779.1\|567699_568884_-\|alanine-racemase	gnl\|CDD\|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	1.59619e-120
NC_014151.1\|WP_013115769.1\|557885_560411_+\|PQQ-dependent-sugar-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	2.06208e-32
NC_014151.1\|WP_013115782.1\|570923_571376_+\|GatB/YqeY-domain-containing-protein	gnl\|CDD\|370480	pfam09424, YqeY, Yqey-like protein. The function of this domain found in the YqeY protein is uncertain.	3.42695e-46
NC_014151.1\|WP_013115761.1\|547037_548456_+\|FAD-dependent-monooxygenase	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	4.0742e-13
NC_014151.1\|WP_043599588.1\|566701_567655_-\|D-alanine--D-alanine-ligase	gnl\|CDD\|234993	PRK01966, ddl, D-alanine--D-alanine ligase.	2.40449e-95
NC_014151.1\|WP_043599590.1\|568880_569504_-\|dipeptidase	gnl\|CDD\|350618	cd14843, D-Ala-D-Ala_dipeptidase_like, D-Ala-D-Ala dipeptidase, includes uncharacterized enzymes. This subfamily of D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) also includes several uncharacterized proteins. This is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. It belongs in the MEROPS peptidase family M15, subfamily D.	3.99201e-54
NC_014151.1\|WP_013115774.1\|563573_564485_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|340419	cd16943, HATPase_AtoS-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS. This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.	3.54965e-46

>NC_014151.1|WP_013115770.1|560441_561029_-|hypothetical-protein
MSAREVHDALHGWAARLVSLGAVVVTRLRPGLTWAEAREVGGLHGYDLTEEVAALWTWRDGVGARPGRAPAHLAPGQDFATLDESLRRSREYLAASRAEERAGTAGTPWQPHWVVAVHGHANPLVLDGSRPGPETFRHDAQADPLVVARSTLPQRIARWHDMLDTGTWRIAPDGTWDVDLSHLTEVPHQARTDVT
>NC_014151.1|WP_013115769.1|557885_560411_+|PQQ-dependent-sugar-dehydrogenase
MRHMRRVAQVVVGVLAVAGLTVGAPSPATAATVPSGFTDAKVADVPSPTALAFTADGRMLVATQGGRLLVRTAAGTLLSTPALDLSSRLCTNAERGLLGVAVDPDPSTRAIYLFYTARGTSSSCPTSQRSNPSGAPTNRVSRFVLRDDNTVDPSSETILLDGIYTVDGNHNAGDLHVGKDGYLYVSTGDASCDYAGDSGCAGRNDAARDRNILNGKILRVVRTTGAPAPGNPFTGTGTATCRLAPAPAGTICQETFAWGLRNPFRFAFDPNASGTVFHVNDVGQNVWEEIDLGTSGADYGWPAREGHCAQTGSASSCGAATPAGMTDPVHDYSHSTGCGSITGGAFVPNGAWPATYDRAYLFADYVCGRIMMLKDGVRTNLATGLGGAVHLEFGPHAGGQALYYTTYTNGGEVRRIAYTGTANRVPTAAVTASPATGPAPLTTTLDGSPSSDPDGDALTYLWSFGDGSASATTTTPTVRHTYAAGSWTATLRVRDAAGATSQPVTVAISSGNTAPAVTMSSPAAGATFTVGDTIRLTGSATDAQDGTLAGSRLSWTVIRVHDAHTHPFLGPVTGTSTSFTAPGPEDLLAAGNSYLRVSLTATDSQGVSTTVTRDLQPRKVDVTLATSPAGRTLTVNGETITGPTTLTSWAGYDLQLGVPAQTDAQGVPYVLSRWSDGSTSATRTWRTPSSAATLTATLAAQSGGLLGTYFDDADLTGASVTRVDPTISFRWGTGAPVSGIGADTFSVRWTGTIVPRYSELYRFATTSDEGVRLWVDGRQVVNKWAAHTEQVHTGTVTLAAGRATPIRIEYYDSTGDATMQLRWWSASQPWQIVPADRLRPS
>NC_014151.1|WP_043598723.1|557349_557751_-|GNAT-family-N-acetyltransferase
MRTPDLRVRYDVDDAALTRLHARAFAAPVPAAPTPWAARLDRHSVTWVGAFHDDALVGFVHACWDGGAHAFLLDAVVDPDHQGCGTGTRLVARLLEEVRAAGCEWLHVDCEVHLEGFYRACGFAPTTAGLLRL
>NC_014151.1|WP_013115767.1|555954_557280_-|SWIM-zinc-finger-family-protein
MTSRTFARPSRLGADGLVLGLAPALTPAGLDPDPSFCHGFAAHPQVLARGLVTLADVTATRYFQPTPTDLRDPVLTAHGDRLRAECFSACSTVYARLDLLPDAFDSGTLGHGTTNVDLGAATRAALTHVGRGRLLHLDVGRGGLTVSSPEGTHVERPVQMPGRWVRALGNVAELHHGLPHAFTVGAVGARAFLAALPAATSGGRSGWLVASRDAVRVAPRTAPGGVHVAGLHRLSAAKRLLTHVTGLAVHGTTEPGPAVVELTLPGARLVLGLTGEAWRGHSGEGSLLSALAGATVAEDADLVAAQLAFEPVVDVARLARGAGLDEPRVRAALAVLAADGRIGWDVHDDAWFHRELPHDPARVEKDNPRLVGARRLVADGKVTPDGDAWTVRRRTGDGPDYRVTRDAGGARCTCPWYLRHGTGRGPCAHVLAVDIATQESA
>NC_014151.1|WP_013115766.1|552652_555958_-|hypothetical-protein
MSATPALLAAVEVFRVLGWADADRQDAPGLPVGTPEQQRVAREGLSRGDWGEWGQLDERTYGWKSWVDVDEWLLTLFAVRVGVDAARSARLLRARPVDDDLMTHLLAPRGPVFARTFVRAAYQPTRRAWEHSTTALAGPVVRLVDLHDLPVPDDVDYLRDWAVYAAGALTGEAGGDLYPATRGWAPPQSITRRLPEHVRAAVAAGVPATGPFGVVLPAAVEQGLVDRDEAVDLALAALDAATRPGDRKAWTQALTGTLAITDAEVVSRADALVPVLAHGEAPVVAAFAPRLVAGVDDGTLADVLVAALTVRTKAVLRTLLTAAAARPRPDAATREVVAPLVVPHATGPDRTLARAAQELVAAWELKVEEAPDDLHDDRVVRWRPTPPVWQVPRFDVGEVSGAALTAAAAALTGRPDEGTDVEVDRFLALANAVAATDRDTARTALGGVRATAVPGLASVAAWVAGTPGPWLDRARTGGLRDITYDPSDAREAAVLQRLGEVPVLLSTPTWVDLRIDPADLVERLRAYVSAAAVVSEADLQLAALRCDVALTTDETVAALEDLPVPVVLQSGALTARTAGPTLAAYLRDPLREPSLEVHGRRRHWQVGPTPVPAALRGLPPRLRTVDWLWRLDMAQHPTWGDAASSKVDAHGEPGSGLVLRQLARRAAPLTPGLAVNVIGALRNLHPAAVADATLAVREAWERGLLRPGVADVRLLGWEETPTQLAAFARVCRELADEGLLSVVWPLLDDLLQVAVAAPRLPPGTSDLAEAVRTLLPDVERAVTAGDAAPDVLALPGTRTLAARGGTSRAVVAARAVVDRLPAVAPDDAPAPVAPPAGPAFDDVWPADAGTRPAIEDGATVRATWVRRNASQRLLSLELTLPDGDTYRVLKTWYYDVTSEGQCAAQSPQAVAADGGVDAWLRWDPGSGRLVVAAHRNDAAGTNSPSELPRAPLSTALVAVLLAGGCGDDGQYHLHDAIGEGLLGSAGVRAAIRALLASPDVDPARLARLTVKDAATLPVLWPVLVEGVRHAAALPAAPRWLPRVLDAATHHAPLLREAAARGLLPADAATWPGLADLAARPATNAGARKARVLAAALGLADG
>NC_014151.1|WP_013115765.1|551187_552456_+|threonine/serine-exporter-family-protein
MPTEPDDDELELIRRSGAVLRVGRLSLASGTGSYRVKASMARVAAALGIDRHQAHVTLTEITTTSHRGRSFRTEVTEVRAVGVNTDRLAELELLAQRVEARAPVTVEDVTAEIDRITAKPPLYPVVLNALWAAVACAAFAFLNNGGTIEVVGAFVGAGLGQGLRRVMLHRGFNQFGVTMLAATLASLSYLGFVQALHVLGLTAGVHEAGYVAAALFLVPGFPLATGALDLAKLDFSAGVARLTWALMIFVSAAFAVWAVSILVGLSPDPPRELALDPAAMTSLRLVASFVGVLGFALMFNSPWRMALVAAGVATLPNVLRIEAVATFAWPPQAAAAVAAFLVGLLAAWIAPRLNIPRITVYVPAVTIMVPGVPAYRAVYHLSNGDVTAALTYGVSAALVVTALAVGLAVARMCTDREWGFER
>NC_014151.1|WP_013115764.1|549898_551020_+|hypothetical-protein
MEDVLDDLYGGSLDDFVARRDAAVRAAKAAKDRDLAGRIGSLRKPTVAAWAVNLLVRDDLSLAGALRDLGEGMRDAERSLDGPALRELGKQRRALVSGLVARARRLASDAGQKLSTAAAQEVEHTLTAALADPKVADAVAAGTLTHGTEHVGFGSADAAEGGRGANGTSGGRSASRPPERTAQSVGTRGPADAGSGTSDAADGEGQGDAPAGGDPSTGRASAAGRTSAGNRAEDAERRERERQEREREKQQRRREQAAAAREAAEADLDRARTRHDDAATAEQQAATALEDAERASAEAYEAEEELVRALADVRRRLAEARAVLPRVDEALVAARSAARDRQKAARAAARELERTTNAAVRAREREERLAAET
>NC_014151.1|WP_013115763.1|548895_549201_+|hypothetical-protein
MPSYRVTATVGLLRPGTQAPDVLPEAVAAARALTTVEAFDVGVVRGQARAMVRFEADDDPAARRVGWAVIERLDELADTTDGHLTRRWGNRWYPAGHRPPR
>NC_014151.1|WP_013115762.1|548465_548894_+|NUDIX-hydrolase
MDIRVAAYAVVVDEGRLLLAHWCEAGFDHWVLPGGGLEPGEDPADAAVREVREETGYDVVLDELLGIDSVVYLSDERIVPGPDLHALRVLYRAHVVGGELTPEVGGGTDEAAWFPLAEVDGLRRVDMVDTARRLAGLLPAGD
>NC_014151.1|WP_013115761.1|547037_548456_+|FAD-dependent-monooxygenase
MDRTGAQDQDVVIVGASVAGLLTAAALARAGRRVTLLDRDDLPDAPEPRAGVPQGRQPHLLLHRGLRAIEELLPGFGARLRAAGAVPVDTGELAWLSPVGWAPSCPQLGILLATRPLIEHALRESVAPLPGVRVVGGVRVTGLRRGGAGEPRWWVDAVPAGWSDGQEPTPEARGADVVVDASGRATRLPRWLAALEVPEAPVEALDAHVGYSTVRVRVPRGRVVAPGVVILAAPGLTGGLALPAEEDLWTVTGFGAGELRPPRDLPALREFLEGVRDDALARVLAAGEVDGDVAAHRQTGNVRHHYERVGPWPDGLLVVGDALCAFNPVYGQGMTVAAMMAQAVRDADARGPLTAPGAAGRLVRACSRVAEGPWQLATSADRALLGEGPPSNPVARLMGRWIDELERMSKHGDLRAQTTLARMFQLVGSPVSLFHPLLVTAAVRTRVRGYGPLAPRPAILREEVGAPVVDER
>NC_014151.1|WP_013115772.1|562055_562748_-|TetR/AcrR-family-transcriptional-regulator
MPAHAPATPVARRERLRQQTVDEIKAHAFALVDAGGAQEVTIASVGKAMGLTPPALYRYFASREALVAALVVDAYADLGATVARAAQDAADQGAAERVRRMLGTYRDWALAHPRRYTLLFSDRTRDVPDSPDGVAAVNVGMLPLLVTLGEIAPGAPDDASPLGEGLRRWAEAIGGPADLSPATLRLAVLAWSRVHGLVSLEITGALDGMGLDAGTLVATEIEHLVEAANR
>NC_014151.1|WP_085955042.1|562895_563264_+|hypothetical-protein
MGRVVMAANAVAAVLAFASGVVVTAGVSDDRLISETWRTLAYLVFAGIWTVLAVAPRRHPGLWELLLFHKAAITVFCLVRWDLTDAPTTALVDLTVTVSTAAAYVLCRGWLAWRQGGPGRNG
>NC_014151.1|WP_013115774.1|563573_564485_+|HAMP-domain-containing-histidine-kinase
MRHKLAMIASGPYDATTLGTLVDLQEQAVEALAKSRAPGAPPPPTALGRADAEDAVTDWLDAHGIAGGWDLAPTFVTARLDPEWLDRVADAVAPGILEDAVRWLGYALETEQLMNDVEDATSRISSLVGAAKQYSQIGRAPDQTLDVHDLLDSTLTMLDRRLDGIDVVTHYDRTLPPVHVYGAELNQVWTNLVDNAAQAMDGHGTLTLTTRRVDDRLEVEIADTGPGIPPEIVDRVFEPFFTTKPVGSGTGLGLDIAWRIVVTKHHGDLSVRSVPGDTRFLVRLPLAGDVSATPPAPDPEVPA
>NC_014151.1|WP_013115776.1|565097_565598_-|hypothetical-protein
MTTRRGTILTAAALALAVAGCAGSADPGAQDTPTPPATGPSTSTAPEDQPDAEPDSAPTPAPAVATVRPGAPDGVTGEDVAAVAGDDPRELQVVTFGSSTCPVVPTDVTWDAGADVLRITLSGTDEYTRPCTMDLVPTTSVVELPDDAPDASGLTVDLRTGTTVVP
>NC_014151.1|WP_148234451.1|565601_566606_-|acyltransferase-family-protein
MLRHAWPDVFPGAGVVGVVMFFALSGHLITGLLVDEASATGRVDLRRFWWRRARRLVPALVVLVAGFVVVTLTLDPLDDAATLGRTVAVSLTYTANVPHVGLVGVSPAVYHLWTLATEEQFYVVWPLVVLLAVRARRLRAGLVLAAVVTAGLCVATAWWFRADPDAAYPLATSWLLCFVVGAACRVAQDRLPAAVAGRHAVVAAVTLLAALVVTGLRGHAATYLLAAPAVAVATCALVLAGRRHVTVRAGWRPLVALGVVSYAAYLWNYPLTLWLRPSLGDATGLVALPATVLAATASWWLVERPLQRRRGGSSHRPRRVMLGAGRQGAPAARG
>NC_014151.1|WP_043599588.1|566701_567655_-|D-alanine--D-alanine-ligase
MCRVAVVGGGANAEHDVSLASAAAVRAALTPSHDVVELTVARDGSWWSGGDALTFAQAVGLVAACDVLLPAVHGPRGEDGTLAALADLAGVACVGSGVRAGAVGMDKWVTKLVAAAVGVAVADGRLVRGVAEACADPRLPAVVKPVSSGSSHGVRRVDTVEDLADAVAAALELDDRVLVEEVVTGREIDVAVLRRADGTTLVSPALEIGHAGAVFDTATKYDGSARFVVPAPLEPADAEALAAAALSVVDALGCDGVARADFFLTARGPVLNEVNTMPGMTAHSQVPVMLAAAGLTYAELVAELVAQARARHAARAS
>NC_014151.1|WP_013115779.1|567699_568884_-|alanine-racemase
MSATLCEPRTGPVAMLAATRPVLTVRLDAVAHNARVLAASARRLMAVVKADGFGLGAADVARTALAHGADALGVATLAEAVELRTARIGAPLLSWLDAPGADLSDAVLHGIDVAVPSLAHLEAAVSAGRRTGRGVDVHLYLDCGTARDGCPPETWPALCAAAWRAELAGAVRVVGVMGHLACAASLDPEANTDATARFAHGVARARAAGLRPRVRHLGATAAVLGLPTTRFDLSRVGAGLVGIDPTGRYPVLRAAAQVTAPVVQVRDVGADVGVGYDHTYRTSAPTRLALLPLGYADGLPVTASGRAEVLVHGRRRPLAGRVSMDQVVVDVGDLAVRTGDVVTVIGTGEDLAPTLTEWAGWAGTLPHELLTGLGRRLVRHVVPAPPSTPCEEPA
>NC_014151.1|WP_043599590.1|568880_569504_-|dipeptidase
MDAVLLSDPRVTAVPVADCGEPLVVAPVPLLRPTHTPGALVRAGVARRLAGAAAALPPGVHLVLAEGWRSPAAQAEIVTRYRATVRAGHADADDHEVERLTSRYVSPVAVAPHVAGAAVDVTLVDDAGRELDLGCPLDATPEESEGRCFTDAPVPPTARVLRTALAEAMAGAGFVNYPTEWWHWSHGDRYWALTTSQRAAVYGPVAA
>NC_014151.1|WP_013115781.1|569734_570871_+|iron-containing-alcohol-dehydrogenase
MGSGRTGSEFVTAGRVVLGAGTAADVPGLVAGLGERVLVVAGRSADVSALTGATVHRHRGEPDVESVRAAVAVARDVRPDVVVGWGGGSVLDLAKCVAVLAPGTSDVLDHLEVVGRGLPLPDAALPVVAVPTTAGTGAEVTANAPVRVPQRGVKASLRGRGMLPAVAVVDPLLTLACPPALTAASGVDALTQCLEAFTTPFATPLTDPLARDGLVRAGRSLRRVVEHGDDVDARTDLSVAALLSGMALANAKLGAVHGLAAALGGRLGAPHGQVCAAVLAPTTAANVAALRRTGAPGLGRYDAAAVALTGRTGARADDAVAWLEDLVTALGVPGLGDLGLARADVPDVVADALAASSTRGNPVALTAEELTEVVAASW
>NC_014151.1|WP_013115782.1|570923_571376_+|GatB/YqeY-domain-containing-protein
MSTLDRLTADLTTALKARDTLRTSTLRQLIGAVRHEEKAGTVARELTEDEVLKVLAREAKKRRESAQIYTDAGAADRAATETAEADVVDEYLPTRLSDDELAALVDAVVADTGASTLKEMGAVMKEATARAAGRADGKALSALVRARLAG

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Crispr_ID: NC_014151_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014151_3

807036-807148

Orphan

Consensus_repeat	Method
CGGAAGGTGACCCGGGTTCCGGTCGGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014151_3

>merge|NC_014151|3|807036-807148|CRISPRCasFinder
CGGAAGGTGACCCGGGTTCCGGTCGGCGGGAGAGGCGGCGGGGGAGGCGGCGGCGACCGGAACCTCACTCACGGTCCGGGGGGCCGGAAGGTGACCCGGGTTCCGGTCGGCGG

>NC_014151|3|3|807036-807148|CRISPRCasFinder
CGGAAGGTGACCCGGGTTCCGGTCGGCGG	GAGAGGCGGCGGGGGAGGCGGCGGCGACCGGAACCTCACTCACGGTCCGGGGGGC
CGGAAGGTGACCCGGGTTCCGGTCGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014151.1\|WP_013115979.1\|797115_798855_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378931
NC_014151.1\|WP_013115989.1\|810184_810523_-\|TraR/DksA-C4-type-zinc-finger-protein	unknown	unknown	gnl\|CDD\|274340
NC_014151.1\|WP_013115990.1\|810579_812229_-\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_013115980.1\|798851_800384_-\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_013115993.1\|813754_816835_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|237603
NC_014151.1\|WP_013115985.1\|804704_806000_-\|acyltransferase	unknown	unknown	gnl\|CDD\|376607
NC_014151.1\|WP_013115996.1\|818068_818656_-\|low-molecular-weight-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|319972
NC_014151.1\|WP_013115984.1\|803778_804708_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NC_014151.1\|WP_187291325.1\|819104_820850_+\|DUF4012-domain-containing-protein	unknown	unknown	gnl\|CDD\|379067
NC_014151.1\|WP_013115983.1\|802814_803774_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NC_014151.1\|WP_013115986.1\|805992_806901_-\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_013115992.1\|812825_813758_+\|DUF3027-domain-containing-protein	unknown	unknown	gnl\|CDD\|378605
NC_014151.1\|WP_148234277.1\|816892_817672_+\|CAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|349398
NC_014151.1\|WP_013115981.1\|800380_801580_-\|cellulase-family-glycosylhydrolase	unknown	unknown	gnl\|CDD\|365907
NC_014151.1\|WP_013115982.1\|801678_802776_-\|polysaccharide-pyruvyl-transferase-family-protein	unknown	unknown	gnl\|CDD\|377253
NC_014151.1\|WP_013115988.1\|808621_809887_-\|putative-glycosyltransferase	unknown	unknown	gnl\|CDD\|340849
NC_014151.1\|WP_013115991.1\|812440_812824_+\|cold-shock-domain-containing-protein	unknown	unknown	gnl\|CDD\|239905
NC_014151.1\|WP_013115977.1\|794590_795589_-\|glycosyl-transferase-family-protein	unknown	unknown	gnl\|CDD\|227350
NC_014151.1\|WP_013115978.1\|795787_797077_-\|LPS-biosynthesis-protein	unknown	unknown	gnl\|CDD\|349772
NC_014151.1\|WP_013115995.1\|817716_818022_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014151.1\|WP_013115979.1\|797115_798855_-\|hypothetical-protein	gnl\|CDD\|378931	pfam12708, Pectate_lyase_3, Pectate lyase superfamily protein. This family of proteins possesses a beta helical structure like Pectate lyase. This family is most closely related to glycosyl hydrolase family 28.	0.000181357
NC_014151.1\|WP_013115977.1\|794590_795589_-\|glycosyl-transferase-family-protein	gnl\|CDD\|227350	COG5017, COG5017, Uncharacterized conserved protein [Function unknown].	2.10012e-10
NC_014151.1\|WP_013115993.1\|813754_816835_+\|ATP-binding-protein	gnl\|CDD\|237603	PRK14083, PRK14083, HSP90 family protein; Provisional.	3.50656e-05
NC_014151.1\|WP_013115985.1\|804704_806000_-\|acyltransferase	gnl\|CDD\|376607	pfam01757, Acyl_transf_3, Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.	7.5903e-17
NC_014151.1\|WP_013115996.1\|818068_818656_-\|low-molecular-weight-phosphatase-family-protein	gnl\|CDD\|319972	cd16344, LMWPAP, low molecular weight protein arginine phosphatase. Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.	1.69623e-35
NC_014151.1\|WP_013115984.1\|803778_804708_-\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	6.35663e-30
NC_014151.1\|WP_187291325.1\|819104_820850_+\|DUF4012-domain-containing-protein	gnl\|CDD\|379067	pfam13196, DUF4012, Protein of unknown function (DUF4012). This is a family of uncharacterized proteins found in archaea and bacteria.	3.07009e-52
NC_014151.1\|WP_013115983.1\|802814_803774_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	1.05756e-32
NC_014151.1\|WP_013115992.1\|812825_813758_+\|DUF3027-domain-containing-protein	gnl\|CDD\|378605	pfam11228, DUF3027, Protein of unknown function (DUF3027). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.34856e-111
NC_014151.1\|WP_148234277.1\|816892_817672_+\|CAP-domain-containing-protein	gnl\|CDD\|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	5.52228e-22
NC_014151.1\|WP_013115981.1\|800380_801580_-\|cellulase-family-glycosylhydrolase	gnl\|CDD\|365907	pfam00150, Cellulase, Cellulase (glycosyl hydrolase family 5).	4.11672e-19
NC_014151.1\|WP_013115982.1\|801678_802776_-\|polysaccharide-pyruvyl-transferase-family-protein	gnl\|CDD\|377253	pfam04230, PS_pyruv_trans, Polysaccharide pyruvyl transferase. Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.	6.17536e-09
NC_014151.1\|WP_013115988.1\|808621_809887_-\|putative-glycosyltransferase	gnl\|CDD\|340849	cd03822, GT4_mannosyltransferase-like, mannosyltransferases of glycosyltransferase family 4 and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.	1.08988e-19
NC_014151.1\|WP_013115991.1\|812440_812824_+\|cold-shock-domain-containing-protein	gnl\|CDD\|239905	cd04458, CSP_CDS, Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. CSP expression is up-regulated by an abrupt drop in growth temperature. CSP's are also expressed under normal condition at lower level. The function of cold-shock proteins is not fully understood. They preferentially bind poly-pyrimidine region of single-stranded RNA and DNA. CSP's are thought to bind mRNA and regulate ribosomal translation, mRNA degradation, and the rate of transcription termination. The human Y-box protein, which contains a CSD, regulates transcription and translation of genes that contain the Y-box sequence in their promoters. This specific ssDNA-binding properties of CSD are required for the binding of Y-box protein to the promoter's Y-box sequence, thereby regulating transcription.	3.04979e-22
NC_014151.1\|WP_013115989.1\|810184_810523_-\|TraR/DksA-C4-type-zinc-finger-protein	gnl\|CDD\|274340	TIGR02890, conserved_hypothetical_protein, regulatory protein, yteA family. Members of this predicted regulatory protein are found only in endospore-forming members of the Firmicutes group of bacteria, and in nearly every such species; Clostridium perfringens seems to be an exception. The member from Bacillus subtilis, the model system for the study of the sporulation program, has been designated both yteA and yzwB. Some (but not all) members of this family show a strong sequence match to Pfam family pfam01258 the C4-type zinc finger protein, DksA/TraR family, but only one of the four key Cys residues is conserved. All members of this protein family share an additional C-terminal domain. Smaller proteins from the proteobacteria with just the N-terminal domain, including DksA and DksA2 are RNA polymerase-binding regulatory proteins even if the Zn-binding site is not conserved. [Unknown function, General].	1.57772e-15
NC_014151.1\|WP_013115978.1\|795787_797077_-\|LPS-biosynthesis-protein	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	3.21727e-24

>NC_014151.1|WP_013115986.1|805992_806901_-|hypothetical-protein
MTDRAAPFPSRRTFLTGAAVAGLGAAGLLLGTPAARASSLPRLPGEISRRADQRTAAGTRYDAVQVDIAGDRAWLTIPQGLRLDEPIGVTWFYHGSGSDHSALLDGFGYESRQLVDRGVVGICQDAGGNGYAGPYAIAAQEAGWRYVSSLADVGANFLRATSGGGALAAEVLGAGLVPDVVGLYFVNAIWDVRRSYDLGGRAEIGPAYGYSTAAIDRTNPARHPASAWAGDRIRIVHTTGVDLVTPPQIHAIPFYERARQQGADVTVRTHDLGHTTPSFVGNEVPIWFTRWFRAWQTDRARG
>NC_014151.1|WP_013115985.1|804704_806000_-|acyltransferase
MAERTGRQGWVDLAKGVAIVMVVAYHALLFLASADVGVAPLGRARLALELYPMPAFFLLAGAMQQRLVTSPWPLVWQRRVLPLVYLLVVWTLVRFAFFTAVPTARADGPLSGRDPATLLLALVAPSSVYWFLWALALVTVVTWLTRRHPVASVVGAVLVSGAVTSGLLVTGVFAWDRALAFLAPYVVGVHAGPWVLRAVTAMRWRHVAAALGTAVLLAAAIVVVPLARNVPGAALLGEAALLAAAFGAAHLVADRAWTRPLRELGRRSLPVYLVHLYPVTLLVLAVREVPALHDMPARGAPLVALVTALALGASMLLARALPTSWRLLQPPAALLRPRGADAATTRAAADGAGLDRRLARAGAGPGAGAVASAGLDRRLAGAGAGAGAGAGDEAGTGGSAGLDRRLAGSRSGPDAGAGPRPSTPDTPPEDR
>NC_014151.1|WP_013115984.1|803778_804708_-|alpha/beta-hydrolase
MTPTSADPRTAARPVAARTAATLVALAALAACAGPPDPVVGVAAHVRPASIERDVTYATPDGTPLTLDAYLPRHGDEPVPAVVLVHGGAFVAGSKDTAGVVGMARRLQDHGVATFAVSYRLAPQHTYPAAVDDVAAAVAWLRDPAQAATYGVDPERVGVVGTSAGATLALTLGARPASVTGVRGVVALSAATLLTAEGLTLGATEPAEVRATLDYLGCPAVDECPVSEQASPALTTTPESSPALLVHGTAESIPLPHAERMAAALTAAGVAHDLVTVEGDAHGAHLLDEHVWSRVLEFLDTRLAPAPGA
>NC_014151.1|WP_013115983.1|802814_803774_-|glycosyltransferase-family-2-protein
MTDLTIVVPTYEAAGWLAGALRAVLAQDVGDLEVIVVDDGSHDGTADLCLAIAARDARVRVVPLESNQGVSHARQVAVEHARAPYVWFVDADDLVAPEAAARMLAAAHRTGADVVMARSRFVYPDSTTRPVPCPTPGPRHGTDVLRTLLRGETSGHLWNKLLRRDLLRPEDFVRARAHSDLALTAAALGRARTAVAIDAHVYDYRLREGSIITSRRSRAESLRVVGDAVARTAAAHGIGPGDPDYDYFRCRFITLSAVKDLVDASAVPDADRLRALRDEIGPRQLRALAARRDTRRLALALTARCSLPAHRVLLALAAR
>NC_014151.1|WP_013115982.1|801678_802776_-|polysaccharide-pyruvyl-transferase-family-protein
MDVLVSAVGQHDNIGDTVLRRAYLDEVRPLGRLHVFVGDKPDGYVAGLGLHPTDVVHRSPGSWRASVRDGLLAGSFYGFDSGETEVRRAYARRYARLAPLLALNRARGGAAVQAGTGVRADHRWRVPIAAVLRLCDVVTWRDAYSRDLMGVGDVAPDWAFALGPDAGTLRAGTDRPLLAVSVRQGTGDVRREPPDASWARRVRALADGLGVTPVVVTQVARDAPLGDRVAHDLRAEHLTWDGHDHAAQEARLRKLYRRCSHVLSDRLHVVVVAATEGAVPVGLATPTALGEAPDKVVRTLRAAGITGTCLPHDLPDVEGAVARLARVDRDTVVDAVLDSRARLVGLGERLRAAGGQSSAASGTAA
>NC_014151.1|WP_013115981.1|800380_801580_-|cellulase-family-glycosylhydrolase
MAAPRRPRHAAATLAVLTALVTALLAPAPAVAATDPSGGNTPATGRPASGVERWGDGSYLNGFSYLRGVNVYSLVFGGDRPAHQVGESQASWDYLASRGVKVARLPVSWVRLQPVPASGNLRAGLDGPVSQAYLDVVEEQVRRAARAGIRTVVGLHNACSYPNIQAPGSVVCGDGVTRADVAKVWTALAGRFAGDERVVAFDLLNETHIDVVPVARYRLFTQAAADAVRATGAQQTLWVQRLLGERGRLDVIAPDGPWVADPLGKVMYSQHFYSSPIGAVFDPLAGNHAVLMDVDRFGTWCRRWNVRCAAGEVGWPSGGPGGVQSAASARGWNLVFEQFYRLADQYGLDVTYFAASSSQTTGTLLAYVASRPGYPSPTGLDTALSQTEVIERHLSRRAR
>NC_014151.1|WP_013115980.1|798851_800384_-|hypothetical-protein
MTGTSSPTAGTALREGPDRPPPGSRAPLPRLPLPRRTLPAYLTVPAGGLVVVVVTAGALLVPVAAVGAAGLAGLAALFWWRPRTGLLLTVVAALLVTQLGALAGAAGGALDEGMIVVGAAVVTARRLLTTGTLVRFPGTWWFVGFGLAGVASSLLQDVPTTLWLAGGLLLLKAVLVGHTAAQLTWDDTHLTTIVRAGVVVAVVLVVTGVLNVALPGLWTGVVAQTTPEMHGPVAAVVGPFRQPAAYGRIAVILAAATLTYQLVVRSTLRGYVLALALSGLALLTFRVKSFVGLVLATAGVVLRAGRPWVVRLALVALPAVLLAAGPTAWRYVVEDLELYYGSGESARALLTAGGLTLAAEHLPLGAGLGRYGSATAAEHYSPEYVALGFEHVWGLGRAEGWGAYLLDTQWPALLGETGWLGTVCYAAGLLCALAVLLRRVPAETPLTRWLRISGVCCLVLVLLDSVGAAAFSSPPSYALLYLAPGIVAGMRAQARGQAGTPARTPAEVAT
>NC_014151.1|WP_013115979.1|797115_798855_-|hypothetical-protein
MSTARPGASTAASADAAGAVPRRAVLAGLGAAGTALLAACTRTPGPTSAVPEPAPTPTPGEPPGRVATDLAGDGVTDDGPALQRHLDAGGHVVLPGPGRYLVDTPLFLDGADPHARVVLDLAGGTLVAGDHLPTSDVFHPDRGTRWLLWPNTLRSAWDPAAGTVEVTVATRATGGRVGALQALAVRDGTFDGRGTTAGLVLAHRTGTELTNVTMVGARALVTWADYSDATRLTGCHARHGEGERHDGALVEQVAPGDGLVLSGCKADAGLFTARLRRCRGAVVDANVTGRLELDRCTGVLVQGGHQECSIGDHTAVVVRRSQVTFRQTAFYCARDGRTPAVLVDDDPAGPDASQVRLEACVEVHLHDARDADTAHGPLLHVASAHDLTEVRADDVRAVTVDTADPGTWVATAGPRLTGTGPVGAAVQDVALLARGFAVSRRTGAWCAEATSAPAVPGAPAAPALDAEPAPGRDGRGGLRARREHTYWAAVRAADGSTSPVVRAGARSTATGAVRLGVTLPTAPAALLLWRGEGGRPTRHTTLPCAVRRVRLLDAGDHVEGVAWAAGTGPTDPTSLPTGS
>NC_014151.1|WP_013115978.1|795787_797077_-|LPS-biosynthesis-protein
MHLDVALRTLRRHGPWGALVVVLALATGFAVLRLVPPTWTAETRVLYGVAGLTGVDQGLPAGTLAAARAAQDAELVGTPAVLQPVMAELDLRGVTVEELGRAVQAEASGTFLDVSVGLADPEAAARVAQTVVAQLALRATDDQLAPAAPDAPVVTLDLAVVQPAVAPERPSSPDPLLTLAGALLVGLFLAALLLTWRARTDTVVDDEHDLAAATPAPVLAHVALPAGRRLADAVTQPPGDVAALRTALLARTGPRAHTAVAVVTCDPPSLDVAAALARAYAGTGRDTLLVDGDLAAPRLAAALGLPGPGLAEVLTGTVSVVEAAQPTSVPALRVLGAGEPEGDRTDLVASRAAEKAWDDVRTSAEVVVVATGRADVAAAVLAAACDEVVLLVAPGRTHRDEVAAAVHALHVAGTAVGGVAWVTGGRSGR
>NC_014151.1|WP_013115977.1|794590_795589_-|glycosyl-transferase-family-protein
MTATAVLPSTHTEPTGGKALLIASTGGHLNELVRLVPTFEPDPDSLWVTFRTPQSETLLAGRRVHYLPYIGPRDLRGTLRAVPQVHDLVRRERFDLAVSTGAAIAVSALPVTAAAGVPSTYIESVCRIVGPSVTGRILSCVPRVALRTQHERWADGRWRTHPSVLDEFRSVPRERPRGGGRLFVTLGTIRGYRFDSVVDAVLASGLADERTVWQLGATTRDDLPGTVTTHLPPDEFARCAVEADVVVAHGGAGTLLDLLALGVYPVQAVRRAGRGEHVDDHQVQIAELVRHRDLGIAVDGPEVTRDVLERAATRRIVPVRTPPLPQQQRRRA
>NC_014151.1|WP_013115988.1|808621_809887_-|putative-glycosyltransferase
MEQFRTTTDDARAASPVDAPAGSPDATAPVDVTRPPRSAADHTDDHAGAAAAITRPDAPGPAQRLRVLHTLNPPDGTTRYVDQMLGGAGGDVDALPFTWTTALRGGYDVLHVHWPELLVRHPRPLRRAARHVALHLLLALLRVRRVPVVRTLHNTVPHESVGRAEARALAAVDAATRLYVLLTPATRAPGDAASVQIPLGHYRDAFAHLPRVAATPGRLVTIGLLRPYKGVEELLAAFTALPGDHLSLTVAGKPTPEIARVVEDAVARDPRITADLRFVPDATFVEHVTAAELVVLPYRQMTNSGVLVAALSLDRPCLVPASPANAALAAEVGEGWVLQYDGEFDAAVLADGLHRAATTPRSARPDLSARDWRVLGAAHDDAYRTAVALARGGARVSGTPAPGTPAHGTPAPGRLTVGGHG
>NC_014151.1|WP_013115989.1|810184_810523_-|TraR/DksA-C4-type-zinc-finger-protein
MDDARARELLLALRADTLGRLTGLGDARQDVVDAARGANVDDEHDPEGTTIAFERAQLEALGAAATRRLAEIDAALARVAAGTYGRCAVGGEPLDDARLEARPTATTCVAHS
>NC_014151.1|WP_013115990.1|810579_812229_-|hypothetical-protein
MSDLFGGWVQESDYTQSQRIRELTDDLGSVRSSLHRASQTASALRNDLAALRGSLDARLTRLSEAFTAFVELSSLRDQLSLVAGPALVRQATRARLVTLGTARADGPVLDVAGSPASPGYWLADALAALGTDDTDAAERAAVIDRRRTATFLTIAGAVTGLPDLVRRWAPDALGDLTPTEPVTRAQRALWLAAAHGLLGDDARAVLLERLRAAVAALPSATADETVTAWGEQVKASASHGGTGPRTSEAAARARRSAATLQALRALVETPADPGDDVPVFGTPDGETAAEDRAAVRTAALDELAAVLRALVDEGAEEERELMTRVAELEAVVAGREAPGATWHAPAGALLDLLRDDALTRRDPAGVLAREATAPWLRRVADAALADGDVPVPTHVDAQALGLTLRARPGEAVEGLGAALERARTPQYVPAAWETPLTVGLAVAAGVLLLAAVVDGSDMQWVYGLAAVAAGIAAVTRFVQGRGKAAQEATRATRAVEFVEREAKALQERTTQAVQAVESARSDAQEAHARVVAGLDEPSPTTPDAVLTDA
>NC_014151.1|WP_013115991.1|812440_812824_+|cold-shock-domain-containing-protein
MPTGKVKWFDTERGFGFIADDEGGEVFLHASALPAGVTAPKPGTKVEFGVADGRRGPQALSVTFLDPVPSVVKAKRAPADEMAVVVEDLIKVLDKVGNDLRRGRYPEGQRATQYATLLRAVADKLEA
>NC_014151.1|WP_013115992.1|812825_813758_+|DUF3027-domain-containing-protein
MAAVKDAVLERAVDLAREVALEIAEVPDDVGEYLGAVRESERLVSHRFACTARGYRGWAWTVTVARVPRGRTATVCEAELLPGEDAILARPWVPWSERLRPGDIGAGDVLPFRPDDPRLEPGYTPTGDPEVDEVAIDELALARVRVLSPQGREEAAQRWYRGSRGPSTAGAVASAGACWSCGFLVPLQGSLGQLFAVCANEWSPDDGKVVSLDHGCGAHSETDVEPGPSEWPAPDPLVDELAIDVVERGAPADEVAQAPVAEPVLDEAAAEPVADEAAAEPVADEPVADEPAEPVADEPAVTDEPATDGS
>NC_014151.1|WP_013115993.1|813754_816835_+|ATP-binding-protein
MTTDVFGTAALRGAVLEAWRASPARLREDANTEEDHARGYYRDRVLVELAQNAADAAVRAGVAGRLLLRLATTDDGTAVLVAANTGAPLDAAGVRSLATLRASAKRDGAPGTVGRFGVGFAAVRAVADEVTVCSTSGAVRFSLADTRQVLDEAAAQEAAQGRPALADEVRRRDGSLPALRLPWQAEGRPPTGYDTAVVLELRDEVVVDEVRTLLRSVDDALLLALPGLVEVLVDVEGDPPRRLADVAARWDVLTATGEVPLALVADRPVEERTARAWRVTWALPRDPSRAPVPHVVHAPTPTDEPCSLPAVLVATLPLDPSRRHVAPGPLTDEVLAHAGAAYAELVGRVAAAGGDVTPLVPTGLPAGAVDGAVRAAALDALARTPVLTPAAPGEDLVPPLRATVVRDLPDGPAAVALAGVVAGLVRVPPGGLAALRALGVEERTLAEVVDELPTAGDVDWAGLYDALDAAAQDATAREGLAALPVPLVDGRVVRGPRGVVLLDDDVAGLAPGTLTALRTWGLRVADPAAARPLLARLGAQRVDAAALLAHPALRAAVLGQADDDDLDHADEVTAAVLDVVRAAGAVPPDAAAWLGLLTLDAADGDAAPAHGLVLPGGAAARLLDDRVLAPVAADLVERWGRDALAAVGVRDDLVVTTVPDVVAGVAPQDDGDDAASLAASSLDGWVEYVDDLADVVGAGVYCGDVAAVADLDAVDDEHWPELLAHVAATPALRAALVTPVRGEGGGAPGPSYTAWWLRTRADLPLPEVFALPGATGLPAALVPPVPEVLAGLDEPVLRALGGVGSLADVPAAGWPAVLDRLGGLGAAVPLDVAGHVWRAWACGAGPVDPPDVVVALTAPGAAHVVDDAVVADDPRWWQLAGADGVAVVPVPVGASSGRAGDAGHAGDAGSAEDAAARVADLLDLPLASSQVDADLTGDAEPEDVPAAVAALLPGAPDVWWHHDDLEVAGVPVGWWVTGEGEVHAVHVEGLAAGLAWVAGRWAVRGAVAALLASPDDGEAALDVVLG
>NC_014151.1|WP_148234277.1|816892_817672_+|CAP-domain-containing-protein
MPVASRREIRRWRQRRVHRRRRVRLVGSAGVLVVALALILLAAPGAYAPAEQVTLALTSGDLVGRLSETVSRSVERSPEPAGVPQPEQSTTDAEPPAEQTPAAGDAQQAEPPPASPSGTAPSPQPRPAAQPAAPATAGDTATTMAAEIVTLTNVERTAAGLPELGVNACATEQAAARSALLVAEGRFEHDPLGPILEACAAGTVGENLSLGYASAQAAVVGWMDSPGHKENILRRSFSQIGVACTQGARGWLCAQVFVG
>NC_014151.1|WP_013115995.1|817716_818022_-|hypothetical-protein
MPSVISTLLHPQRTPPPPIDVDLARVMWAGTTVWGAAVPVTGALWLLGVISGIWVATCGAGAVLGLIGVRWARTHGRLADDGSGAMVRPDHDALARKTPTA
>NC_014151.1|WP_013115996.1|818068_818656_-|low-molecular-weight-phosphatase-family-protein
MTSPQPPARILVVCTGNICRSPAVERLLAARLVGSDVEVTSAGTRAVVGHPVSDLMVPLVRGAGASADGFAARQLTADLVRDADLVIALTRGHRSAIVELVPAAVRRTFTLLELARLVAHVDPTVVHAAGSPGDRVRALPTLAAAVRHVAGQGDDDVEDPIGGNEAVYQASYDQMAPAVATIATALQGWSPAATA
>NC_014151.1|WP_187291325.1|819104_820850_+|DUF4012-domain-containing-protein
MSLIGFAFVLGASAAWFVFSALEARDALLAARSDVGLLQEQARTGDVDGARATLEDVQRHASVARSRTGGPVWAAAGVVPRVGPNVRAVQTVAASIDDLARGALPSLVDATAVVDPARLAPVDGRVDLAPLQSVAPGLSAAAETVRAATLCLDAVDTAALMPQVGEPFEQLRAQLAAVGADTATAARAAALLPGMMGMDGPRQHLLLVQNNAEPRALGGIPGAVILLRADQGAVEMVELRNAAGELSGLPEPALPLTDVELALFGRQLGIYMADVTFTPDFPRGAEMAAAIWEKQLGGRIDGVLSIDTGGLAAVLGAIGPVAMPDGAVAEATGGQLTSENAVEVLNNTVYRLVEDSAEQDAFYAATGAAIFDAVLAGEGQPVPTIDALASAARDGQLLVWSAHGEEQRQIAGTVLSGELRGSRDGTPVVGFYVNDGTGSKIGYYLQAEYEVTPGQCYADGSRLIDVEATFTSTAPPEVIDMPPYISGTRLEPGRMRFNVLAYAPRDGLVDGVEVQDGRTGGASHVHDDLFVVARTVELDPGESTVINYQIRSGPGQSGAPEVRTTPLVDNRVNVVEGWQCG

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Click the colored protein region to show detailed information

Crispr_ID: NC_014151_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014151_4

1021146-1021250

Orphan

Consensus_repeat	Method
GTGTCGATCGTGTCCGCCTCGGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014151_4

>merge|NC_014151|4|1021146-1021250|CRISPRCasFinder
GTGTCGATCGTGTCCGCCTCGGCGGGCGGCTCCTCGGCGGACGGCGCGGAGGAGTCGGCTACGTGAGGTATCCGTGCACCGTCTCGATCGTGTCCGCCTCGGCGG

>NC_014151|4|4|1021146-1021250|CRISPRCasFinder
GTGTCGATCGTGTCCGCCTCGGCGG	GCGGCTCCTCGGCGGACGGCGCGGAGGAGTCGGCTACGTGAGGTATCCGTGCACC
GTCTCGATCGTGTCCGCCTCGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014151.1\|WP_013116181.1\|1027109_1028309_+\|threonine-ammonia-lyase	unknown	unknown	gnl\|CDD\|236182
NC_014151.1\|WP_013116171.1\|1017623_1018028_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|223619
NC_014151.1\|WP_013116177.1\|1023086_1023500_+\|ribonuclease	unknown	unknown	gnl\|CDD\|350322
NC_014151.1\|WP_013116185.1\|1030454_1030829_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235668
NC_014151.1\|WP_081449758.1\|1029594_1030458_+\|mycothiol-conjugate-amidase-Mca	unknown	unknown	gnl\|CDD\|132487
NC_014151.1\|WP_013116182.1\|1028403_1028889_-\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NC_014151.1\|WP_013116172.1\|1018165_1019437_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|130740
NC_014151.1\|WP_013116170.1\|1016629_1017487_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|184875
NC_014151.1\|WP_013116168.1\|1015039_1016041_+\|acetylxylan-esterase	unknown	unknown	gnl\|CDD\|368448
NC_014151.1\|WP_013116179.1\|1024618_1025854_+\|cystathionine-gamma-synthase	unknown	unknown	gnl\|CDD\|236104
NC_014151.1\|WP_148234480.1\|1025877_1027113_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NC_014151.1\|WP_148234479.1\|1023823_1024453_-\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|234604
NC_014151.1\|WP_052302677.1\|1029076_1029532_-\|DUF4307-domain-containing-protein	unknown	unknown	gnl\|CDD\|379491
NC_014151.1\|WP_013116166.1\|1012690_1013530_+\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_148234284.1\|1020488_1020929_-\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_148234478.1\|1019463_1020246_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_014151.1\|WP_187291332.1\|1012414_1012687_-\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|237756
NC_014151.1\|WP_013116167.1\|1013549_1014956_+\|cystathionine-beta-synthase	unknown	unknown	gnl\|CDD\|273464
NC_014151.1\|WP_013116169.1\|1016048_1016633_-\|WHG-domain-containing-protein	unknown	unknown	gnl\|CDD\|379115
NC_014151.1\|WP_013116176.1\|1022868_1023096_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014151.1\|WP_013116181.1\|1027109_1028309_+\|threonine-ammonia-lyase	gnl\|CDD\|236182	PRK08198, PRK08198, threonine dehydratase; Provisional.	0
NC_014151.1\|WP_013116171.1\|1017623_1018028_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	1.45192e-28
NC_014151.1\|WP_187291332.1\|1012414_1012687_-\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|237756	PRK14559, PRK14559, serine/threonine phosphatase.	2.07984e-08
NC_014151.1\|WP_013116182.1\|1028403_1028889_-\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	1.00159e-54
NC_014151.1\|WP_013116172.1\|1018165_1019437_-\|FAD-binding-protein	gnl\|CDD\|130740	TIGR01679, bact_FAD_ox, FAD-linked oxidoreductase. This model represents a family of bacterial oxidoreductases with covalently linked FAD, closely related to two different eukaryotic oxidases, L-gulonolactone oxidase (EC 1.1.3.8) from rat and D-arabinono-1,4-lactone oxidase (EC 1.1.3.37) from Saccharomyces cerevisiae.	1.93581e-48
NC_014151.1\|WP_013116170.1\|1016629_1017487_-\|alpha/beta-hydrolase	gnl\|CDD\|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	6.20341e-23
NC_014151.1\|WP_013116168.1\|1015039_1016041_+\|acetylxylan-esterase	gnl\|CDD\|368448	pfam05448, AXE1, Acetyl xylan esterase (AXE1). This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyze the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan.	3.51461e-138
NC_014151.1\|WP_081449758.1\|1029594_1030458_+\|mycothiol-conjugate-amidase-Mca	gnl\|CDD\|132487	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca. Mycobacterium tuberculosis, Corynebacterium glutamicum, and related species use the thiol mycothiol in place of glutathione. This enzyme, homologous to the (dispensible) MshB enzyme of mycothiol biosynthesis, is described as an amidase that acts on conjugates to mycothiol. It is a detoxification enzyme. [Cellular processes, Detoxification].	1.23997e-157
NC_014151.1\|WP_148234480.1\|1025877_1027113_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	1.1921e-52
NC_014151.1\|WP_148234479.1\|1023823_1024453_-\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|234604	PRK00058, PRK00058, peptide-methionine (S)-S-oxide reductase MsrA.	5.19347e-119
NC_014151.1\|WP_052302677.1\|1029076_1029532_-\|DUF4307-domain-containing-protein	gnl\|CDD\|379491	pfam14155, DUF4307, Domain of unknown function (DUF4307). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	3.91339e-27
NC_014151.1\|WP_013116185.1\|1030454_1030829_+\|hypothetical-protein	gnl\|CDD\|235668	PRK06007, fliF, flagellar basal body M-ring protein FliF.	0.00303935
NC_014151.1\|WP_148234478.1\|1019463_1020246_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	0.000449735
NC_014151.1\|WP_013116177.1\|1023086_1023500_+\|ribonuclease	gnl\|CDD\|350322	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins. This subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC3 and VapC21 toxins. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.07928e-41
NC_014151.1\|WP_013116167.1\|1013549_1014956_+\|cystathionine-beta-synthase	gnl\|CDD\|273464	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase. Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family].	0
NC_014151.1\|WP_013116169.1\|1016048_1016633_-\|WHG-domain-containing-protein	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	5.61606e-17
NC_014151.1\|WP_013116179.1\|1024618_1025854_+\|cystathionine-gamma-synthase	gnl\|CDD\|236104	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional.	0

>NC_014151.1|WP_148234284.1|1020488_1020929_-|hypothetical-protein
MAVAVITVVVVAVACCAEARIGPRGTELGLVLGRYNPGVLSVSVPDGALPVVALALMCVPVTLAAIGRRATRGRPTTSRCTGAAAVVTVVVAPVIVVTAVATALGAADSDWMVAALIWPQVSAVVAVIAVAAVGDSIRPRRPSPRI
>NC_014151.1|WP_148234478.1|1019463_1020246_-|CPBP-family-intramembrane-metalloprotease
MVAAALVCGSAVLMFAIHVRPLAYVPLVLGVVLGWAVDRVLGRDLLVIAAGMSIVSTIPLAADLSDLGMVQFTIALSLAVVIPYLLSTHVNGDRVIRFPWRTGKRWNRTQWAYLLFVVGAGYLILPFYFLDSGAYRNWPTVVEGHEIARLFVGVNAVGTWDELFFVCTVFALLRRHFGLWTANVLQALVFVSFLWELGYREWGPLLTIPFALIQGFTFNLTKSLTYVLVVHLLFDAVVFMVLVHAHTPELFDVFVTAPAR
>NC_014151.1|WP_013116172.1|1018165_1019437_-|FAD-binding-protein
MTDALTTWAGSHTFRGGPVVRPRTVEEVADVVAGARHVRALGSRHSFHDLADSPGTLVALDRLEVPTVIDPDAGTVTVGAGVRYGELAQDLHAAGWALHTMASLPHIAVAGTVATATHGSGDTAPNLSSAVRGLEIVGAGGEVRTLGPDDPELAGSVVALGALGVVTRVTLAVQPTFDVAQEVWLDLPWTTALDRFDALTSSAYSVSLFTDWTGDAVKQVWRKHRVDGDAWTLPGPGEVLAGARPAPGPQHPVPGPDPVACTQQGGVPGAWHERLPHFRLDFTPSAGAELQSEWLVPRAHATAAIDALRGIGHVTSPLLLVSEIRTVAGDDLWLSTAHGGDHVALHFTWKPLRAEVEAALPVIAAALAPFAARPHWGKLFAADAATLRGLYPRWDDQLALIARRDPDGIFANDFLRRVGLRPA
>NC_014151.1|WP_013116171.1|1017623_1018028_+|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MAAALPEVSGAPGTKPTLTFPDASPSGELEVVVLSRGDGALVEAGQDIEVHYLGQSWQGGVFDNSFDRGSSISFPIGVGAVIAGWDEGLVGQQVGSRVLLSIPSHLAYGDRGVPQAGIKGGDTLVFVVDIVGVS
>NC_014151.1|WP_013116170.1|1016629_1017487_-|alpha/beta-hydrolase
MAPLLVIPDGTVSYDVHGPADGPTVVLVPGLGDLRSSWRDLVGPLVDAGHRVVTTDVRGHGDGTHGFTRHGVEPTADDVRELLDTLDVDAEHPAVLVGASFAAGAVARVAAQDPDRVRGVVLVAYAGNGEPAGRSVRLQIRLLLARPWGPRAWTGFYRSLLRGRKAAWTDAHLADLRRALRDPAALADVRALALALVGGGHRTLLGQVTRPVLVVTGTLDPEHPDPTAAHAATMAAVPHDAVTGVLVPEAGHYPQHQRPDVVVPALLDFLAGLTTRGDVTRGGVA
>NC_014151.1|WP_013116169.1|1016048_1016633_-|WHG-domain-containing-protein
MSPRAGLDRSAVTEHALAVVDDGGSRAWDTLSLAAVAARAGVAVPSLYKHVEGLPGLRREVALRAVTELDEVVAGATGAPDPQQRLRDVAQAIRAWARRRPGRYQAVQGGWLAHADAADVAAVGARVVARLSDLVADLGVPSERRIDAVRAVRAAVHGFVALELDGGFGMREDVDVSFAYLVDGIVAGLRRTAA
>NC_014151.1|WP_013116168.1|1015039_1016041_+|acetylxylan-esterase
MALFDLPLPELERYLPELDEPADLDEFWAATLAETRAFDLDVRRAPHDSPLTLVDVEDLTFAGFGGHPIKAWVTRPAGSATDGSSLPAVVEFLGYGGGRGRPLERLAWAAAGYVHLLMDTRGQGSHWGSGGDTADPAPGSGPQVSGFLTRGILDPAEHFYRRVFTDGVRAVEAVRALPGVDPARVAVTGGSQGGGMTLAVAGLVPDLAAVMPDVPFLCHVPRAIAITDAEPYHEVVRYLSVNRERKAAVMRTLSYLDGVHLARRATAPTLFSVALRDPICPPSTVFAAYNHYGALADQRPDRAIEVYEFNEHEGGGGFQLDAQLRWLAGVLAR
>NC_014151.1|WP_013116167.1|1013549_1014956_+|cystathionine-beta-synthase
MKYAQHVSELVGGTPLVRLSSVTTGLTATILAKVEYLNPGGSVKDRIALRMIEAAEASGELQPGGTIVEPTSGNTGVGLALVAQRKGYRCVFVCPDKVSQDKRDVLRAYGAEVVVTPTAVPPDHPDSYYSVSDRITRETPGAWKPNQYANVNGPASHYASTGPEIWADTDGRVTHLVAGVGTGGTITGTGRFLKDVSADRPAADGGRVVVVGADPAGSVYSGGDGRPYLVEGVGEDFWPTAYDPAVPDEIIAVSDADSFDMTRRLAREEGLLVGGSCGMAVEATLRHARDLQERDPEAAARAVYVVILPDGGRGYLSKIFNDGWMRSYGFLSAGDGASVADVLRSKDGALPDLVHTHPTESVRDAIEILREYGVSQMPVVGAEPPVMIGEVAGSVSERELLDAVFSGAASLADRVDKHMAPPLPLIGSGEPVEAARAALEKADALMVVDDGRPVGVLTRHDLLGFLTH
>NC_014151.1|WP_013116166.1|1012690_1013530_+|hypothetical-protein
MRLPRTVLTLTALLLLTACAAGEPGAAPTTSAPAGGTGGGPGGGGEPTAPAEPAAPALPASCAAIELVTGARIASVDLATCLTDYIRAAGSGRFESRLEGQVSDQRWALVDGGLYAVGSRNGEPSVAVTPDTGWLFTDGTWVQADPGGSSEQMRAADGVDGYRTTSEPGMTYAMIAVAPGFTVGERAEVELADGTTTSLWPIRADGPFQPIPAIPATTTELVVWTDVPGPTARLDVTGTAVDGTGQTTTGTSTTFYEDWGQGVDLAEIEELVGVPLPRP
>NC_014151.1|WP_187291332.1|1012414_1012687_-|zinc-ribbon-domain-containing-protein
MTSSVRVTRAGPGDLSANVAGRRARVKEPGIDLRTRSVARCPSCSAQSAGGRFCQECGSSLAAERTCESCSATNPASARFCSGCGTPSGA
>NC_014151.1|WP_013116176.1|1022868_1023096_+|hypothetical-protein
MPDILVRGLSEAAVAHFDAEAASLGLSRAEVLRRHLEAEVRADAPRPTMTPDDWDRFAREFGDLGDPEVMASAWR
>NC_014151.1|WP_013116177.1|1023086_1023500_+|ribonuclease
MAVTTWLVDKSALVRLPYAVERDLWQARLERGLLRLAHVTRLEVGFSALSGRSAREAASAPPVSLMPVEHLTPGIEARALEVQTLLADRGEHRAASIPDLLVAATAEKLGMTVLAVDKGFDLIAHVTGQPVERLAFE
>NC_014151.1|WP_148234479.1|1023823_1024453_-|peptide-methionine-(S)-S-oxide-reductase-MsrA
MVDAEHALKGRDGYAYRVPETHVVLGTPLQGPWPEGTRVLYLASGCFWGAEKEAWQLPGVVTTAVGYMGGFTPYPTYEETCTGRTGHTETVMVAYDPTVLSDVDLLRHFWEEHDPTQGFRQGNDVGTQYRSAVFFTTPEQEAAARTTRDAYAPVLKARGYGDVTTEIRSVEDAGTFYYAEDYHQQYLRKNPGGYCPVNSTGVACPVPSA
>NC_014151.1|WP_013116179.1|1024618_1025854_+|cystathionine-gamma-synthase
MTHDPLAQPHDWTDSGFSTRAIHAGQDPDPRTGAVVPPIFQVSTYKQDGVGGLRDGYEYSRSGNPTRDALQQALAAVEGGDAAFAFASGLAAEDTLLRAVLRPGDHAIVPNDAYGGTYRLVARVLGPWGIEHTPVDLSDPDAVLAAIQPGRTKVIWVETPTNPLLGIADIAAIATHAQAAGIVLAVDNTFATPYLQQPLALGADVVVHSTTKYIGGHSDVVGGAVVVADGAQLPAGTEGPTGTTSLRDAVGFLQNASGAVAGPFDAWLTLRGLRTLAVRMDRHVANAEAVARFLVEHPGVNEVLWPGLPEHPGHEVAARQMTGFGGMVAFRTGSAESAVAVCAATRVFTLAESLGGVESLIEHPGRMTHGSVAGTALEVPDDLVRLSVGIEDSADQLADLEQALTAAGIHR
>NC_014151.1|WP_148234480.1|1025877_1027113_+|AI-2E-family-transporter
MTPRPDPVPASVRAWAGWSWRALVILAALAAGLWLVAALKVIVVPVAVALLLTVLLSPVVRALQRYVRLPRSAAAGTALVGLIALVAGLLTLAGRSIVNGIAELWEQARSGFDELLTWLSEGPLQLGTGEIEDYLGQVQDAAASSGQQLVSGALSVGVTVGHVAAGTLIALFCTLFFLIDGRGIWAWLVGLMPRGSRERVHQAGRRGWVTLGAYTRTQILVAAVDAVGIGIGAAFLQLPLVVPLAVLVFFGSFIPFVGAIVTGSIAVLVALVTQGWVSALIMLGIVLLVQQLEGHVLQPFLMGHAVSLHPVAVLLVVTTGSLVAGIVGALFAVPLAALVNTVVLYLHGHDKFPQLGVDDHVPIRAKGHPVLDRAVAAAAEAESEARAARGEGSAHGGAEGTTSGDDSPVTP
>NC_014151.1|WP_013116181.1|1027109_1028309_+|threonine-ammonia-lyase
MIGPDDVRAAAALVAGVAERTPVQRSRALSGMVGADVWLKCENLQRAGSFKIRGAYTRMARLTDAEKARGVVAASAGNHAQGVALAADLLGLDAVIFMPVDAALPKIAATRGYGARVELVGTSVDEALVAAHEHAGRTGAVLIHPFDHPDVDAGQGTLALEVLEQVPDVGTIVVPVGGGGLAAGVAAALDERPDVRVVGVQAAGAAAYPVSLAAGRPTRAPELRTMADGIAVGTPGAVPFEVLASHRVPVRTVSEEDLSRALLLVAERAKLVVEPSGAAAVAAVMADPRGIAPDGRPIVCVLSGGNIDPLVLLRVVRHGLASAGRYLQLHVVVEDTPGALAELLREVAAMGGNVMHVSHLRTGDDLAFSDVAVDLQIETKGPEHCGTLLAGLRAAGYRC
>NC_014151.1|WP_013116182.1|1028403_1028889_-|transcription-elongation-factor-GreA
MTETTAATWLTQEAYDRLTEELEYLQTVGRKEITDRIAAARDEGDLKENGGYHAAREEQAKQEARIRELQAKLRNVQIGTPPDDGVVEPGMVVTAVVAGDEMTFLLGSREIAGTADIDVFSPTSPLGAAIHGHKVGDSTTYEAPNGRQIPVEIKAASPFQG
>NC_014151.1|WP_052302677.1|1029076_1029532_-|DUF4307-domain-containing-protein
MIPHTTDTRARPPGGPTVVAPAPRPPAGRYGPEPTATTRRLQRLGLAAVVVVAMVVLAWIGTGVMRDPVLWQDVGYRVDGPASTEVTFDVTTPLGAAATCRVQALSSSYAQVGVLDVPVPPADTRTRRVTVTVPTVELAVTGVVQGCEPVD
>NC_014151.1|WP_081449758.1|1029594_1030458_+|mycothiol-conjugate-amidase-Mca
MAVHAHPDDESSKGAATTARYAAEGVDVLVVTCTGGERGDVLNPGYGPAPEGLEAMAAVRREEMAAAAAALGVRQRWLGFVDSGLPEGDPLPPLPEGSFATLPLEEASAPLVAAVREFRPHVMTTYDPSGGYPHPDHIMCHRVSAEAFAAAGDRERYRGLGEPWTPLKLYYNHGFSLARMRAVHDAIVAAGGESPFSDWIDSRQAREVPERQVTTRIECADWFDRRDAALRAHATQIDPEGWFFAVPREVELATWRDEEYELAESRVETTLPETDLFAGIRGTEHAR
>NC_014151.1|WP_013116185.1|1030454_1030829_+|hypothetical-protein
MTTSALAATALVAGARFSQRLPGPTYESPTEGSPGFAGFVATFALALAIIALGISFTRRIRRSDHRERQRAAAEAALAAASGAPEGTPGDGTSAEPTGGARTRADADPETEGGVAEPPAAGERA

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Click the colored protein region to show detailed information

Crispr_ID: NC_014151_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014151_5

1068442-1068540

Orphan

Consensus_repeat	Method
CACCCGCCGACCGGAACCTGACTCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014151_5

>merge|NC_014151|5|1068442-1068540|CRISPRCasFinder
CACCCGCCGACCGGAACCTGACTCACTGTTCGCGGGCCTGGACGGGTAGCCAGGTTCCGCTCGGCGCCCACCCCACCCGCCGACCGGAACCTGACTCAC

>NC_014151|5|5|1068442-1068540|CRISPRCasFinder
CACCCGCCGACCGGAACCTGACTCAC	TGTTCGCGGGCCTGGACGGGTAGCCAGGTTCCGCTCGGCGCCCACCC
CACCCGCCGACCGGAACCTGACTCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014151.1\|WP_013116204.1\|1067134_1068430_+\|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	unknown	unknown	gnl\|CDD\|236947
NC_014151.1\|WP_013116197.1\|1055057_1056098_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NC_014151.1\|WP_013116196.1\|1054338_1055061_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_014151.1\|WP_013116199.1\|1058916_1062276_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376899
NC_014151.1\|WP_013116203.1\|1066274_1067108_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_014151.1\|WP_043598809.1\|1073939_1075208_+\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_148234482.1\|1062472_1063885_-\|aspartate-ammonia-lyase	unknown	unknown	gnl\|CDD\|234779
NC_014151.1\|WP_043598806.1\|1068603_1068921_+\|DUF2087-domain-containing-protein	unknown	unknown	gnl\|CDD\|378279
NC_014151.1\|WP_013116198.1\|1056115_1058920_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669
NC_014151.1\|WP_148234483.1\|1064122_1065319_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270453
NC_014151.1\|WP_013116202.1\|1065315_1066278_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_014151.1\|WP_013116213.1\|1077410_1077941_-\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_013116211.1\|1075229_1076669_-\|DNA-recombination-protein-RmuC	unknown	unknown	gnl\|CDD\|376878
NC_014151.1\|WP_013116195.1\|1051026_1054299_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|274576
NC_014151.1\|WP_043599840.1\|1072844_1073870_+\|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	unknown	unknown	gnl\|CDD\|234893
NC_014151.1\|WP_013116208.1\|1071405_1072671_-\|exodeoxyribonuclease-VII-large-subunit	unknown	unknown	gnl\|CDD\|272979
NC_014151.1\|WP_013116212.1\|1076731_1077262_-\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_043599834.1\|1069697_1070714_-\|carbohydrate-kinase	unknown	unknown	gnl\|CDD\|238572
NC_014151.1\|WP_081449759.1\|1069008_1069614_-\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|239473
NC_014151.1\|WP_052302791.1\|1070734_1071007_-\|exodeoxyribonuclease-VII-small-subunit	unknown	unknown	gnl\|CDD\|179195

Protein	Function_ID	Function_description	E-value
NC_014151.1\|WP_013116204.1\|1067134_1068430_+\|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	gnl\|CDD\|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	4.78308e-172
NC_014151.1\|WP_013116197.1\|1055057_1056098_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	8.64452e-95
NC_014151.1\|WP_013116196.1\|1054338_1055061_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	4.5572e-105
NC_014151.1\|WP_013116199.1\|1058916_1062276_-\|ABC-transporter-permease	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	1.66745e-05
NC_014151.1\|WP_013116203.1\|1066274_1067108_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.82482e-77
NC_014151.1\|WP_148234482.1\|1062472_1063885_-\|aspartate-ammonia-lyase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NC_014151.1\|WP_043598806.1\|1068603_1068921_+\|DUF2087-domain-containing-protein	gnl\|CDD\|378279	pfam09860, DUF2087, Uncharacterized protein conserved in bacteria (DUF2087). This domain, found in various hypothetical prokaryotic proteins and transcriptional activators, has no known function. Structural modelling suggests this domain may bind nucleic acids.	6.86254e-15
NC_014151.1\|WP_013116198.1\|1056115_1058920_-\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	0.0073657
NC_014151.1\|WP_148234483.1\|1064122_1065319_+\|extracellular-solute-binding-protein	gnl\|CDD\|270453	cd14750, PBP2_TMBP, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose; possesses type 2 periplasmic binding fold. This group represents the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.52486e-69
NC_014151.1\|WP_013116202.1\|1065315_1066278_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.58864e-73
NC_014151.1\|WP_013116211.1\|1075229_1076669_-\|DNA-recombination-protein-RmuC	gnl\|CDD\|376878	pfam02646, RmuC, RmuC family. This family contains several bacterial RmuC DNA recombination proteins. The function of the RMUC protein is unknown but it is suspected that it is either a structural protein that protects DNA against nuclease action, or is itself involved in DNA cleavage at the regions of DNA secondary structures.	2.52981e-117
NC_014151.1\|WP_013116195.1\|1051026_1054299_-\|FtsX-like-permease-family-protein	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	6.59832e-06
NC_014151.1\|WP_043599840.1\|1072844_1073870_+\|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	gnl\|CDD\|234893	PRK01045, ispH, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed.	0
NC_014151.1\|WP_013116208.1\|1071405_1072671_-\|exodeoxyribonuclease-VII-large-subunit	gnl\|CDD\|272979	TIGR00237, exodeoxyribonuclease_VII_large_subunit, exodeoxyribonuclease VII, large subunit. This family consist of exodeoxyribonuclease VII, large subunit XseA which catalyses exonucleolytic cleavage in either the 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. Exonuclease VII consists of one large subunit and four small subunits. [DNA metabolism, Degradation of DNA].	9.02012e-138
NC_014151.1\|WP_043599834.1\|1069697_1070714_-\|carbohydrate-kinase	gnl\|CDD\|238572	cd01167, bac_FRK, Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.	1.97321e-63
NC_014151.1\|WP_081449759.1\|1069008_1069614_-\|carbonic-anhydrase	gnl\|CDD\|239473	cd03378, beta_CA_cladeC, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	6.44195e-54
NC_014151.1\|WP_052302791.1\|1070734_1071007_-\|exodeoxyribonuclease-VII-small-subunit	gnl\|CDD\|179195	PRK00977, PRK00977, exodeoxyribonuclease VII small subunit; Provisional.	5.1478e-19

>NC_014151.1|WP_013116204.1|1067134_1068430_+|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC
MAAITLSHVVKKYGDGYPAVNDVSLDIDDGEFVILVGPSGCGKSTLLRMVVGLEDISDGEIRIDGDVVNDKAPRDRKLAMVFQNYALYPHLSVFENIAFPLRLEKGRYPESEIRARVEKAADTLELREHLERKPANLSGGQRQRVAMGRAIVREARAFLFDEPLSNLDAKLRGQMRTEIARMQRRLGTTTLYVTHDQTEAMTLGDRVAVLKKGVLQQAASPRALYEQPVNLFVAGFIGSPPMNFLPGEVDGDVLRLPFADVPLTDALRSRVGDRELVIVGLRPEHLEDADTLDDETRGKGVTFEADVDVVEWLGAELYAYIPFETRDDVAATLAELDRDLDGEGMRTQLVAALGAESHARDGDVAELWFDPSRLLVFDPETGDNLTFDEEAARKADEDSVEERKRATERARKRAERTEAKERGSSDRDTAA
>NC_014151.1|WP_013116203.1|1066274_1067108_+|carbohydrate-ABC-transporter-permease
MSARAKVWWWVGGIAIFLYCLFPVVWIVSLSLKAPADLDDGRFLPSSVSWQNYELILSGSASELFLPALRNSVGICLIATAIAVVLAALCAYAVARLDFPGKAFVLGLSLAVSMFPVISIVTPLFNIWRSVGLFDTWAGLVIPYLSITLPLSIWTLTAFFREIPWEMEQAAQVDGATTAQAFRKVIVPLAGPGVATTAIIAFFLAWNDFVYGISLTSTEAARPVPAALAFFTGASQFEEPTGAISAAAVIVTIPVVVLVLLFQRQIVAGLTQGAVKG
>NC_014151.1|WP_013116202.1|1065315_1066278_+|sugar-ABC-transporter-permease
MSAATTAVPAAAEAARGTRRRAPLSDRRRQEARLGLLLASPAIVVLLAVVGYPILQAVWDSLFNYKLTNPDARSFVGLGNYGLILSDPIWWQALGVTVLITVVTVVVELVLGFALALVMNNALGALRPGLRTAILIPYAIITVVSAFAFRFMFDLTSGFVNAWLPFVGDDTDWFASFGTAVTVISISEIWKTTPFISLLLLSGLAQVPGELQEAAKVDGATWWQRMRRVTIPNMKAAIMVALLFRTLDAFRIFDNIFIMTNGAAGTESVSFLAYRQTIQRLEIGIGSAVSVLLTIAVALIALMFVKGFKVNLAASTRAGR
>NC_014151.1|WP_148234483.1|1064122_1065319_+|extracellular-solute-binding-protein
MWYINPDSGGQARIASECSEESGGAYRLEVTLLPRDAPSQREQLVRRLAAGDTSIDLMSIDPPFVPEFANADFLAEVPDDVADAVTQDVAEGAVAAATFDDELVVVPFWANTQLLWYRKSVAEAAGLDMTQPVTWDQVIQAAADQDVTVAVQGTRAESLTVWVNALVESAGGHVLENPEEEDPRAVVPSLDSDAGRTAAQIIADLTAAGVGGPQLSNATEDINASMFESDDAGFMVNWPFVWQRGKAGVEGGSLDQATLDDYGWAMYPQAVEGEQARPPIGGVTLGVSAFGEHQDLAFEAAQCIVQPEKQAAYYISDGNPPGSLAAFDDPEVQEEFPMADLIRESLQHAAPRPQTPFYNEVSSSIQRTWHPPRSVSPDSGPGRADTLVMDVLQGRALL
>NC_014151.1|WP_148234482.1|1062472_1063885_-|aspartate-ammonia-lyase
MNAPDGAGEYRIEHDTMGEVRVPAHALYRAQTQRAVENFPISGSTLERGHVEALARVKKAAAKANAELDVLPQDVADAIVAAADEVASGVHDAHFPVDVYQTGSGTSSNMNTNEVLATLATRLLGRDVHPNDHVNASQSSNDVFPTSVHVAATAGVVRDLVPALEHLAGALEEKATAWATVVKSGRTHLMDATPVTLGQEFGGYAAAVRYGVERLQAALPRAAEVPLGGTAVGTGINTPAGFPQRVIALLVEDTGLPLTEARDHFEAQSSRDGLVELSGALRTIAVSLTKICNDLRWMGSGPNTGLGEIALPDLQPGSSIMPGKVNPVVPEAVLMVCSRVVGNDATVAWAGASGSFELNVQIPVIASAVLESIRLLANASRVLADRTVAGTTPNVERARALAESSPSIVTPLNRTIGYENAAKIAKHAVKQGVTIRQATLDLGFVERGELTLEQLDTALDVLAMTRPPQA
>NC_014151.1|WP_013116199.1|1058916_1062276_-|ABC-transporter-permease
MVWRTQVLLGRLRDQATVLATVALVTFVATTLLGTFALLLDATGDDAVDAALGRLPDSAITLEATIRVNNKDTQTALDAAGDTLAAMLGDVPTERTAWLTGRTWSLPRVEGAPVAPLAYPASTPLVPDQTELLSGTWPDAARDDAGRLLVNVPGVAAERYGWAVGTEVPVRTLGGQAEDTWLVVGTHEITGPPASWSRDPLGGAGHDAAYPVPGTLGKLVTDLWGPVVVAPEALLGPGVTERAHLLVLPDLTGAPRGALATARDSLTSGQVRLSAALTDVGVSGSIRTDLGTTIDAAWRELTVTRVGVVVVGLLLAVLATTVMLQAARLLGERRAAEGELVAARGASPAQLRSLAVLEAALLAVLVTGTAPWAARALFARLADTGGMSAAGLTAPPGVPPAVWFACAGVATVLAVALVVPSWHVSGSSHASAHAHLVRTGADVALVALGGVALWQLLDYGAPLTRGADGPRLDPVLVLGPALVTLAAAVLALRLVGPVGRGADALARRGTTLVVPLAAWQVARRPAAATGTILVVVLAVAAATFSHAFLATWRLSQLEQVDLALGTDARIEGARGEPLVVSADVRGALADAPGDAVLQPVVVRNVGVGRALGADRGSSAIDARVIGVDASTPDLLRGRGPEPWEDVVRDLPHPPGSARAPERTATGTELPGDPQWLLARVTPGSAPEASGRAYLRIAVEDEAGARAWLATPELLLGEPVDIALEVPRARGPLRVVAASFVVALDGTPFEVAVATSPRDKLGQIGLAVHDVRVLDRSVDAGTPDEATLAAAQGTPVDLSGAPWEGSATSGGVVRDVLVGSAATAPAPSGLPADALVLDGLFDMSTLDASTGRLVAHAWPAQERVRAVVTESLAERADLRDGAGFVMRIGDAQVDVYVEAVVPYVPGAPRGPALLVDRTALGRVVTEAAGTDPLLDAWWLAAPPAQTADLAGAVAHATGGHATVRSTERAAAVAGPLRVTVPAALSLVTAATAMLVLVGLGSSAAAVVRSRRLELARLQALGASRRSLVGGLLGEHALLVLLGAGTGALIGYGLSRVVAPVLTVSGDGRRPVPAPVVDWQAEETFAITAGLALAGCAVVALLATVLVRRASGALLRLGDDR
>NC_014151.1|WP_013116198.1|1056115_1058920_-|FtsX-like-permease-family-protein
MSTLGTRVRATTAHALLVTQRRAGQDRSLLVGTALLLLVTLVLTLGVPRLVERTADEAVQETVRAAGRDADLVAVPVANPDRMGPLDPELEAYGAAGFLGQELGDVIEMPVATVVGAPATVRTPAGAFSLDLVHVGRLRDTEPAVRWVAGTEPTAVPDDQQNGRVLGDDGPRSVQVGLSVAAAEALGVSIDDGPFTARRQTSGGWNHIVVTGLYEPVDPQDALWAGRPGLLAAVTSPVGAETRLQTSAYVPRASVPDMVHVLGTLGVAASARAAVRTDGLTVAGVHDVVHTIEALAARSGRLTSGLPGVVEAFDARMSAARAQSSLVVAGVASAAALCLVLAASLLVTRRRPFLAAERARGASIASVAARGLVESVPVVLAAALLAGVVVLVPLHDQPGSALLTVAVATVAALAPAALAAREAVGAWNGRRVPADRRARAAQQARRRARRVVVEVSTVLLAAGALVSVRGRGLVPLSAGEVDPLLAAAPVLVASAAALVVVRVSPAVVRWAGRGASRSRGLAAPLAVARAHGATTAVVPLLTVTVCVALVVLSGTLVHTVRVGQQAAADQLVGAPVRLDGRLGTFSGRDVLEAVAQAPGVTTLATGAQIPRRTFGERTGLTATLLVVDAAELAQVRAAAGLPVDDGLAALGEPGPAGTVPALVSADLLARSGTLGAGTQGTGTSGTEAIVSALNATLRLDVRGTTGLTPDAGAPTLDARITDTVGDDDGLVVVDRALLARVADQAPSVDRAWVAGPGAVAAVEAAGVPPEDRSGIVVTTRDGWWRAWSQAPLTSALTTLFLASVGVLAALAVLALALVVVATARERGRTLSALRTLGLDARTARWATLGELAPLVLGGLVGGAVIGLGVPLLVGDALGLQRLTGEPTGTTVVLTWWPVVAAVTALTVALVVAVAVEQAVRRRDRLGDVLRVGER
>NC_014151.1|WP_013116197.1|1055057_1056098_-|ABC-transporter-ATP-binding-protein
MDDGPTVQDAPPTSLATLEERARARPEAFGRTSLIVCESLVRIYQAEGIEVQALQGLDLLVDEGELVAVVGASGSGKSTLLSVLSGLDVPTAGNVRVGEWDLMTMTARERVEYRRSTVGFVWQQTARNLVPYLTAAENVELPMALAGRPRKQRRSEAAALLDVLGVAYCAARRPSQMSGGEQQRVAIAVGLANSPRVLFADEPTGELDTATSNDVLEAMRAVNRDLGTTVVVVTHDPSVSEHVQRTVEIRDGRTSTEVLRRTATRDDGTEHEVAEEFAVLDRAGRVQLPREYRETLELVGRVRLTLEQSHVAVRPGHDRPGHDRPGHDAPPAATDPQHPSHGRRAR
>NC_014151.1|WP_013116196.1|1054338_1055061_-|ABC-transporter-ATP-binding-protein
MTATTTDRRGAGSAADAPLVVVEHVDRTYGSGHAAVHALRDVSLTVAPGELVALVGRSGSGKTTLLNTIGGLDRPDGGRVVVAGREVSSLDEKGLVALRRDVVAFVFQTFGLVPVLTAAENVGVPLRMRRTPVAEREARVELLLDLVGLGPHARQRPGQLSGGQQQRVAIARALANSPRLLIADEPTGQLDSETGRAVMALIRAVVEAEGMTAIVSTHDPVMVALADRVVNLADGRLVDA
>NC_014151.1|WP_013116195.1|1051026_1054299_-|FtsX-like-permease-family-protein
MRWRGRLLRGRGQDQAPVVLVVTLVAVASATLVGLLAGLLHVAERDAVPQAISRLDPQRTHLEATLWVRGDDVEPALDRARDGLARITGDVPTTERTWLIGGLRALPTELGVPPELTYLAALPHDDEDLVRLASGRWPAASTDADGRVEVNVPVVAAQALGWEVGSTVHARPWGEEHGDAFVVVGTHEPAGPRSAWSRDRLRGQGRSAGFNLPGSAGLIRTTAWGPLVVDPAVLTRPQMVDTAYLVVEPDLAASTADAVAALRTQVDDGARILSDALTGPVSGRLQTDVDTTIDATWRELVVTRAAVVTIGLLLGTLATTVLLLTARLLAERRAGEAELLAARGASPAQLRSTVLLEALVLATLTWLVSPWLARGALAVVTRSGPPAEAGYTVPEGVPGGVLLACGAIAVALAVTLCVPAWHTAGSTSRSVHGGLLRVGGDLALLVLGALALGQLVAYGSPLTRGADGPRLDPVLVAGPALVCLAAATVALRLVAPVARAGERLARGARSLVLPLAAWQVARRSAVATGTVLVVVVAVAAGTFSAAFAATWRTSQVEQVDLALGTDLRADAIEEDPLAASAALAAATAAYPDAHGQPVTDRVVGMGPRGNTGGVGGRLVALDASRPQDLRGRSTTPWREVVAGLHADEPSTTVGTELPAGTQWLVLTGSVDTDPFLSGTAVLGLGVEDDQGVLTQLPPRTAPLGRPFEVVLEVPVADRLRVVATDLTVSVHEPESVLTTDSRLVPVRTTLTSLRAVPRSAGIGRELDVHEAPAQPVPLRLDGWTGVVTQGESTVGAPELVPVGAPGAWHVTGTMKVDTWGTPPVRVLSAAWPLPRTVPAAVSESVLDVLETRQGLTITVAGVSVPLQVERLVEQVPGVPRGIGVVVDRTTLSRAVLTAGGRTDLLDSWWVAAPATTTAALAADLAGVDADVTTRAAERHDALTGPVRVAVPTAVSLVAVSAVLLVLVGTGAVAAASLRSRRLELARLQALGASRAGLVGGLLAETTLLVTVGALAGLAAGYGLAAAVAPLLTMSPDGRTPAPEPWLVWGWGTQSLRTLGVVAAACAVTALVAVLGVRRTSGAALRMGDDR
>NC_014151.1|WP_043598806.1|1068603_1068921_+|DUF2087-domain-containing-protein
MEEGATTRVCDAERFLVRGRWVTTPRRSTDRDTLLEHVAALLVAPGEELDEATLTARVAEIADDPVRVRRDLVESGLVGRRQDGSLYWRERRTAHDDEPAARRAG
>NC_014151.1|WP_081449759.1|1069008_1069614_-|carbonic-anhydrase
MLHPSQGIDRRTELSAEQHPFAVLFGCSDSRVAAEIIFDQGLGDLFVVRTAGHVLDTTVIGSIEYGTEVLSAPLVVVLAHDSCGAVAAATEAIAHGNPTPGFVQAVVDRVIPSIVRLTASGRPLESFDAATLGHEHVLHTARQLHAYSVALADAVAAGRTAIVAVEYTLADGRARLVEVIGDVGFGPGVVPQPEPLDVIEG
>NC_014151.1|WP_043599834.1|1069697_1070714_-|carbohydrate-kinase
MPAGGAGAGRALVVGEALVDAVRHPDGSSAEHPGGSPANVALGLARLGRRADLLTWLGADARGDLVRRHLEASGVRVLHGDRTPAATPVATAHLDPAGVATYEFDLEWDLPSTWDEDADDALVVHTGSIAAVLTPGGPKVADLLGSRRATSTLTYDPNLRPALMGDPADVLPVVERLVRGVDVVKVSDEDLAWLQPGVAPAEIAETWVRTGPALVVVTHGGEGAFAVTSAGARLSVAAPRVTVADTVGAGDSFMGGLIDGLWSAGLLGAGRRAALHDVDADTVQAVLERCARIAAITVSRPGANPPTRVELDEPTTDAQPAVDATTPTLPTDPKGAGA
>NC_014151.1|WP_052302791.1|1070734_1071007_-|exodeoxyribonuclease-VII-small-subunit
MAPRETTAGGAPTASEPLPDPAALGYEQARDELGAIVARLESGAGTLEESLALWERGEALAARCQEWLDGARARLAAAREGAPGDEEADR
>NC_014151.1|WP_013116208.1|1071405_1072671_-|exodeoxyribonuclease-VII-large-subunit
MHDETSALAAGAPPAALPLPLKAADTTPERPWPVRHLAPKVADYVARMPPVWVEGQLLNVRRWNSLLFLTLRDTDLDMSISVTLPAVAAMSLGDRFADGAHVVVHARPQYQVKKGSLGFAADRVRLVGLGELLARIEQLKGVLAAEGLFDDARKRALPFLPGVVGLVCAQQGDAEHDVVSNARARWPAVQFEIRRVTVQGPSAVPEVSAAIAELDADPRVEVVVVARGGGSFEDLLPFSNETLVRAAAACRTPLVSAIGHHMDSPLLDLVADLRASTPTDAAKRVVPDVTEERARLVQARTRTRAAVQHRLAREESTLAHLRSRPVLARPETLVDPHVDVLRRLTARGRAVVDAAVALAATETARLAGQVRALSPAATLERGYAVVQRADGVVVRSPDDVTAGDRLRVRVAAGELTAEVTT
>NC_014151.1|WP_043599840.1|1072844_1073870_+|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase
MRAADAPRKRVLLAAPRGYCAGVDRAVIAVEKALEHYGAPVYVRKEIVHNRHVVDTLAARGAVFVDETDEVPEGARVVFSAHGVSPAVKASAAARNLQTIDATCPLVTKVHKEAVRFAADDFDILLIGHTGHEEVEGTQGHAPEHIQVVNSPDDADHVEVRDPERVMWISQTTLSVDETMETVRRLRVKFPHLQDPPSDDICYATQNRQVAVKKLAPSCDVVITVGSANSSNSVRLVEVALDAGAGVSYRVDKAAEIDPAWLVGATTVGVTSGASVPEILVSDVLAFLAEHGFGEVEEVRTATEDLMFSLPRELRADLKAAGEPTGRPRPDGRRRLDVQPV
>NC_014151.1|WP_043598809.1|1073939_1075208_+|hypothetical-protein
MKTPPTHSPDPRAAWRRRVLALVASASAVTLLAATPAAALGTSLPGKTPVPVATVTPSGALSTVIPAGTWLDVENSQGSTKMFPVGDEMSVAVGDAGEKRLVTLTIPTTLEKTRGPVDRAMLIWSVRCHPIEDTHDGIIGGVRQPKAGDVTSTGTVVSGSPVNGKNLTRNVLLGETHTAVVRTLVEFSSPGHYTCRGEWGARSRFAVGGEKVKVVGTSTLEATAPVADPENAVNCYWPATKEFVGGHPEDCYYSAAPEPGSAAERAVPGGAALRINKVRTTVAKPSDTAPGRWMLAQAHLAVTTCAGSQQSTSPCTTADLGGGSLVEGTIVLRDQDDQPYPAACVEVDRTLDGTKRLDVSSAVHHDAVLVELRFRIKPRPTSTSTSMCEHRNLRLTSHVAVLSGKAAWAEHSASQLSVLVEP
>NC_014151.1|WP_013116211.1|1075229_1076669_-|DNA-recombination-protein-RmuC
MHVTAALAAVTPAATPGAGSLVAALLAGLVVGAALAWAAASARAARTTADRVRAAEVEAARARALLDAERAGAGDRFRALADEALAATSEQFLALAHQRLAAEHQTQVGELAQREQAVRAMVEPLARTLEHVRAELVEAERARVEGNAALGEQVRAMRAASEQLRGETSQLVTALRSSQVRGRWGEVQLRRVVEAAGMLAHVDFVEQEQVRTDDGLQRPDMVVRLAGGKHVVVDAKVAFLGFLEAAQTDDERVRAERLTAHARHVRKHVDDLASKRYWDQFAPAPEFVVMFVPAESFLHAAADQDPTLVEYAFERNVVLATPTTLLALLRTIAYAWRQDALAANAQQVLSLGKELHGRLATMGGHLARLGRSIDAAAGAYNQAVGSFESRVLVSARRFADLHVVDADLPTPEPANPRLTALSAPELVASATEQVVSLDDAVLGSGSTARDARAFDEEAARTASHRAGSGFDEGRAAPGA
>NC_014151.1|WP_013116212.1|1076731_1077262_-|hypothetical-protein
MTTPRWDRLVATSRPNLSVVEGLHGRPSALVRPARQRWEEEARNAPLVRVSVVQADRSLDDPTDRRPRDAVVLYTTDPRLCRDTAWLAEVTQRVRAVRGGRSGDPALARLRDLLDGGRDGVVEDVPKRLTGGVRTRIQATRIGPGELPGPTVPEDGMLLGLALETGVRLLRTAQYE
>NC_014151.1|WP_013116213.1|1077410_1077941_-|hypothetical-protein
MQSGKWESLVATPRPVTKEIEEVWTKPFFFLRGAVRKWEQGVVHAPLVFASVVQANRVLWDAEHSTFAPAVLLYSRDPARSRDAQWLRELTERVRALKETRTGDPAVDRFADLLADEDSNFFEDLPASLTGGAHARMHVTFVNPADLPGRAIPEDGLLLGLGLEESVKLLPASYYA

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Crispr_ID: NC_014151_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014151_6

1597329-1597431

Orphan

Consensus_repeat	Method
CGCCCGCGAGACGTCGATCCAGCCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014151_6

>merge|NC_014151|6|1597329-1597431|CRISPRCasFinder
CGCCCGCGAGACGTCGATCCAGCCCCGACGCTCGCGCTCTTCCTTCGCCCGCCTCCTCTCCTTCGCCCGCCTCCTTCGCCCGCGAGACGTCGATCCAGCCCCG

>NC_014151|6|6|1597329-1597431|CRISPRCasFinder
CGCCCGCGAGACGTCGATCCAGCCCCG	ACGCTCGCGCTCTTCCTTCGCCCGCCTCCTCTCCTTCGCCCGCCTCCTT
CGCCCGCGAGACGTCGATCCAGCCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014151.1\|WP_013116663.1\|1588649_1589498_+\|apolipoprotein-acyltransferase	unknown	unknown	gnl\|CDD\|143592
NC_014151.1\|WP_148234514.1\|1603788_1605201_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NC_014151.1\|WP_013116669.1\|1594760_1595897_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|378117
NC_014151.1\|WP_013116666.1\|1592044_1593010_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223673
NC_014151.1\|WP_013116679.1\|1607856_1608498_+\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_013116673.1\|1600130_1601951_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_014151.1\|WP_013116662.1\|1587100_1588441_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|185378
NC_014151.1\|WP_148234307.1\|1605185_1606115_+\|hypothetical-protein	unknown	unknown	unknown
NC_014151.1\|WP_043600125.1\|1598331_1600134_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224055
NC_014151.1\|WP_013116680.1\|1608484_1609984_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|224458
NC_014151.1\|WP_013116671.1\|1597478_1598240_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|226674
NC_014151.1\|WP_013116675.1\|1602571_1603624_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|273670
NC_014151.1\|WP_013116678.1\|1606111_1607860_+\|VWA-domain-containing-protein	unknown	unknown	unknown
NC_014151.1\|WP_013116668.1\|1593878_1594661_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223673
NC_014151.1\|WP_013116667.1\|1593006_1593882_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213260
NC_014151.1\|WP_081449766.1\|1585503_1586145_-\|cellulose-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366161
NC_014151.1\|WP_013116665.1\|1590956_1592048_+\|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|163554
NC_014151.1\|WP_013116664.1\|1589524_1590943_+\|dihydropyrimidinase	unknown	unknown	gnl\|CDD\|236240
NC_014151.1\|WP_013116670.1\|1595982_1597317_+\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|235687
NC_014151.1\|WP_013116674.1\|1601969_1602575_+\|nicotinamide-mononucleotide-transporter	unknown	unknown	gnl\|CDD\|377432

Protein	Function_ID	Function_description	E-value
NC_014151.1\|WP_013116663.1\|1588649_1589498_+\|apolipoprotein-acyltransferase	gnl\|CDD\|143592	cd07568, ML_beta-AS_like, mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases). This family includes mammalian-like beta-AS (EC 3.5.1.6, also known as beta-ureidopropionase or N-carbamoyl-beta-alanine amidohydrolase). This enzyme catalyzes the third and final step in the catabolic pyrimidine catabolic pathway responsible for the degradation of uracil and thymine, the hydrolysis of N-carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyrate to the beta-amino acids, beta-alanine and beta-aminoisobutyrate respectively. This family belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 5. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Beta-ASs from this subgroup are found in various oligomeric states, dimer (human), hexamer (calf liver), decamer (Arabidopsis and Zea mays), and in the case of Drosophila melanogaster beta-AS, as a homooctamer assembled as a left-handed helical turn, with the possibility of higher order oligomers formed by adding dimers at either end. Rat beta-AS changes its oligomeric state (hexamer, trimer, dodecamer) in response to allosteric effectors. Eukaryotic Saccharomyces kluyveri beta-AS belongs to a different superfamily.	1.06028e-141
NC_014151.1\|WP_148234514.1\|1603788_1605201_+\|AAA-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.51218e-10
NC_014151.1\|WP_013116669.1\|1594760_1595897_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|378117	pfam09084, NMT1, NMT1/THI5 like. This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.	3.78478e-31
NC_014151.1\|WP_013116666.1\|1592044_1593010_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	2.14094e-29
NC_014151.1\|WP_013116673.1\|1600130_1601951_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.14904e-160
NC_014151.1\|WP_013116662.1\|1587100_1588441_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|185378	PRK15481, PRK15481, transcriptional regulatory protein PtsJ; Provisional.	1.71052e-80
NC_014151.1\|WP_043600125.1\|1598331_1600134_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.24205e-134
NC_014151.1\|WP_013116680.1\|1608484_1609984_+\|AMP-binding-protein	gnl\|CDD\|224458	COG1541, PaaK, Coenzyme F390 synthetase [Coenzyme metabolism].	1.96072e-18
NC_014151.1\|WP_013116671.1\|1597478_1598240_+\|SDR-family-oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	2.37776e-80
NC_014151.1\|WP_013116675.1\|1602571_1603624_+\|AAA-family-ATPase	gnl\|CDD\|273670	TIGR01526, nadR_NMN_Atrans, nicotinamide-nucleotide adenylyltransferase, NadR type. The NadR protein of E. coli and closely related bacteria is both enzyme and regulatory protein. The first 60 or so amino acids, N-terminal to the region covered by this model, is a DNA-binding helix-turn-helix domain (pfam01381) responsible for repressing the nadAB genes of NAD de novo biosynthesis. The NadR homologs in Mycobacterium tuberculosis, Haemophilus influenzae, and others appear to lack the repressor domain. NadR has recently been shown to act as an enzyme of the salvage pathway of NAD biosynthesis, nicotinamide-nucleotide adenylyltransferase; members of this family are presumed to share this activity. E. coli NadR has also been found to regulate the import of its substrate, nicotinamide ribonucleotide, but it is not known if the other members of this model share that activity.	3.67257e-55
NC_014151.1\|WP_013116668.1\|1593878_1594661_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	4.34549e-40
NC_014151.1\|WP_013116667.1\|1593006_1593882_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213260	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters. NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	8.82596e-116
NC_014151.1\|WP_081449766.1\|1585503_1586145_-\|cellulose-binding-domain-containing-protein	gnl\|CDD\|366161	pfam00553, CBM_2, Cellulose binding domain. Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.	6.9121e-13
NC_014151.1\|WP_013116665.1\|1590956_1592048_+\|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|163554	TIGR03842, F420_CPS_4043, F420-dependent oxidoreductase, CPS_4043 family. This model represents a family of putative F420-dependent oxidoreductases, fairly closely related to 5,10-methylenetetrahydromethanopterin reductase (mer, TIGR03555), both within the bacterial luciferase-like monoxygenase (LLM) family. A fairly deep split (to about 40 % sequence identity) in the present family separates a strictly Actinobacterial clade from an alpha/beta/gamma-proteobacterial clade, in which the member is often the only apparent F420-dependent LLM family member. The specific function, and whether Actinobacterial and Proteobacterial clades differ in function, are unknown. [Unknown function, Enzymes of unknown specificity].	0
NC_014151.1\|WP_013116664.1\|1589524_1590943_+\|dihydropyrimidinase	gnl\|CDD\|236240	PRK08323, PRK08323, phenylhydantoinase; Validated.	0
NC_014151.1\|WP_013116670.1\|1595982_1597317_+\|aspartate-aminotransferase-family-protein	gnl\|CDD\|235687	PRK06062, PRK06062, hypothetical protein; Provisional.	0
NC_014151.1\|WP_013116674.1\|1601969_1602575_+\|nicotinamide-mononucleotide-transporter	gnl\|CDD\|377432	pfam04973, NMN_transporter, Nicotinamide mononucleotide transporter. Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide.	4.21109e-47

>NC_014151.1|WP_013116670.1|1595982_1597317_+|aspartate-aminotransferase-family-protein
MAAPVEVDGLTLDAETVALDRAHVFHSWSAQARVAPLVVAGGSGSTVWDHAGHTYLDFSSQLVNTNIGHQHPRVVEAIREQAGLLATIAPATANLTRGRAAAAILGHAPDRLTKVFFTNAGADAVENAIRLARLHTGRDKVVSHYRSYHGNTGAAVVATGDWRRVPNEYARGHVHVFGPYLYRSEFWATALEEECERALRHLERIVQCEGPDSVAAILLETVPGTAGVLVPPPGYLAGVREIADRYGIVLILDEVMAGFGRTGEWFAFDAHDVVPDLVTFAKGVNSGYVPAGGVLISSQIAATFDERVFPGGLTYSGHPLAMAAIVAAIGAMEDEGIVENAAAVGRDVLGPGLAELAERQSLVGEVRGTGVFWAVELVADRATREPVAPAVMGAVRAACLARGLLPFVADNRVHVVPPCVVTPDEAREGLALLDEALTEVTTDL
>NC_014151.1|WP_013116669.1|1594760_1595897_+|ABC-transporter-substrate-binding-protein
MRTTTRRGATVAALAAAGLLLAGCSTTDTAEADGGEGDLTPVTLQLQWLTQAQFAGYYAAVAEGYYADEGLDVEIVPSGGDIVPQDALAAGEVDYAIAWVPKVLGSIEQGAQVTNVAQVFERSATLQVAFADSGIASVADLEGRTIGSWGYGNEWELFAGLNQAGVEDFELVTQAFDMLGLLGGDIDAAQAMTYNEYAQLLETVDPDTGELYTPEDFTVIDWNDEGVAMLQDAIWADAARLADDEEYQETTVRFLKASLKGWAFARDNPQDAAEIVTAAGSTLGTSHQLWMTNEVNKLIWPSTAGIGIVDEAAWERTVKLAMETHNETGATIITSEPPETAYTNAYVEKALAELEEEGVDVTGADFAPVDVELQEGGN
>NC_014151.1|WP_013116668.1|1593878_1594661_+|ABC-transporter-permease-subunit
MSGGAVARRRGTVRQVLPPVVLLVALVTTWHAVVTLGDVPAFVLPGPAAILDELTTYLGPVTSAALVTGGNALVGLVVGATLGVLLAVVAAVVRLVDVLAEPVVAALAVVPVVALAPVLYAMYGAASEQARVLVAALAVFVPVYVTTLRGLRQVRPVHRDLMHALAATPRQAALAVTVPTAVPFVFTGLRMASSLAVISAIVAEYFGGPRSGIGSFITTAASASNYARAWAYVLGGVVVGLAFYAVTAAAEHVATRRAGA
>NC_014151.1|WP_013116667.1|1593006_1593882_+|ABC-transporter-ATP-binding-protein
MSVVQEQPASTPHPRGAVAVEVEQVSRVFAGRSGDVHALQGVDLTVAAGEFVSLIGPSGCGKSTLLRLVADLDEPTAGTVRVFGRSAREARLARDYGIAFQQAGLLPWRTVRANVELPLALSGTGRAGRRERADELLALVGLSDFADHHPDQLSGGMQQRVAIARALAVSPSLLLMDEPFGALDEMTREHLQAQLLRICAETRAAVVFVTHSIPEAVFLSDRVVVMSPRPGRIREVVPVTLDRSGAATPAVGPTDDAGDDLRNDAAFVASVAAVREALHGGSATGRGVDVR
>NC_014151.1|WP_013116666.1|1592044_1593010_+|ABC-transporter-permease-subunit
MSTTTDTPAVAPSGAPAPASGATVRARGTRLARLTRVRPLVAVTSALAVAALWEAYKLLGPAQGWAVGETRLLPRTTDLAMPHTWQVAARLLEPVSGATGADVLWLAVLRAGAFSFGIALVGWTIGVLVGALLALTMLRVAVVERAVLPLVVLSQTVPLIALAPLVRSWGARLEIGSFAWQPWMSVAVIASYLAFFPVAVGALRGLQSPDRIHVDLMRACGAGWGTTLVRLRLPAAVPHLLPALRLAAANAVVGAVVAEVATGLPGGLGRMILEFANFAASDPPKPWAPILGAVLLGLVAAGLVALLGRSLRRYRRVEVAP
>NC_014151.1|WP_013116665.1|1590956_1592048_+|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase
MDFGVVLQTNPPASRTVELARQAETHGFTHVWTFDSHLLWQEPFVIYSAILAATRKVMVGPMVTNPATRDWTVLASLFATLNEMYGNRTVCGIGRGDSAVRTLNGRPSNLATLRQSIHVIRELANDRPADLGERTVRFPWSKGSALDVWVAAYGPLALKLTGEVGDGFILQLADPDIARWMVRAVRDSAEAAGRDPDEVDICIAAPAYVGDGASPAARAHMREQCRWFGGMVGNHVADIVRRYGTDSAIPKALTDYVRDREGYDYNEHGRAGNSHTTFVPDEIVERFCLLGSPHEHVEKLRELEALGCDQFAVYLQHDNKEETLRLYGERIIPAMAEPVVATAASSGATTPPDPVDVPQAVTA
>NC_014151.1|WP_013116664.1|1589524_1590943_+|dihydropyrimidinase
MTTTLIRGGTVVSATGRAPADVLVDGETIAAVLAPGSTLLGHDLAGSIDRVVDATGRYVVPGGIDAHTHMELPFGGTSASDTFETGTRAAAWGGTTTIIDFAVQRAGERVQDGLAAWHAKAAGNCAVDYAFHQIVGGVDDDALKAMESLVDEGVTSYKLFMAYPGVFHSDDAQILRAMQKAADLGLLTMMHAENGPAIDVLAAQLVEQGRTDPYFHGIARAWQLEEEATHRAIMLADVTNAPLYVVHVSAKQAVQQLAWARDAGRNVFGETCPQYLYLSLEEQLGAPGFEGAKWVCSTPLRSRAEGHQDHMWQALRTNDLQMVSTDHCPFCMKGQKELGLGDFRAIPNGIGSVEHRMDLMYQGVVTGQITLERWVEITSTTPARMFGLYGRKGVIAPGADADVVVYDPTGHTSIGVASHHMNMDHSAWEGFEVDGHVDLVMSRGQVLVDADGYHGRPGHGRYLKRDLTQYLV
>NC_014151.1|WP_013116663.1|1588649_1589498_+|apolipoprotein-acyltransferase
MSVVRVAFTQATWTGDKESMIRLHEDWTREAASAGAQVIAFQELFYGPYFGITQDTAYYDYAEPVPGPTTERFSRLAAELGIVVVLPIYEEDQPGVLYNTAVVIDADGTVLGRYRKHHIPHLPKFWEKFYFRPGNLGYPVFDTAAGRIGVNICYDRHFPEGWRVLALHGAQIVFNPNATAPGISNRLWEIEQPAAAVANGYFVVANNRVGREDNEYGEDAVNFYGSSYAVGPDGSYVGEVGSSSENQLLVRDLDLDQVREVRERWQFFRDRRPEAYGPIVAP
>NC_014151.1|WP_013116662.1|1587100_1588441_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MSPQELADLVADRSPRGIAATIARLVHAGDLLPGDRLPTVRELAGALGVSPATVGSAWQTLASAGLVISRGRAGTSVLPGPAGRLPPRYRDLADAPAARLDLAAGSPDPELLPDLAPALSRVASRRHGRPASGYLDDPVVPELERLLRSSWPFLPQRLTVVDGAVDALSRVLEQVSGFGDRVAVEDPGFPPVLDLLDHLGLERLPVPLDTHGPRPEALESAVAAGARVVILQPRAQNPTGVSTTPTRARELAAVLRPVAGQVWVVEDDHSGEIASSRDVSLGQLLPDRVVHVRSYSKSHGPDLRIAAVGGPAVVLDGLVARRMLGPGWTSRLLQHVLADLLTDAPAVEAVAHARRVYHGRQRALCAALARHGLALAPGDGINLWVPVRDEQTALVKLEAAGVRVARGRPFVVDPTRSPGFVRVTVGVLRAEDVEHVAAALAQAARA
>NC_014151.1|WP_081449766.1|1585503_1586145_-|cellulose-binding-domain-containing-protein
MFYDALKAACVDTQFFSVPGAGHSHADVTSSSRFGRQTVRTVEGCRETVTQGTPNPSWDTIAAFLKDAWAGGTSTPTPTPTPTTSPTPSPTDSPTPTPTFSPTPSPTPSPTPTPTPTPGTGNGCSATYRVVNAWPNGFVSEVKVTAGGASLSGWRVSMTLPGGQATQVWNGQSSGGVVSNAPWNGSLGAGQSTTFGFQGTGSGEGATVSCSAS
>NC_014151.1|WP_013116671.1|1597478_1598240_+|SDR-family-oxidoreductase
MPTTDRPRRALVTGASSGIGAATVRRLRADGWDVVATARRADRLAALAADTGADAFAADVTQDADVAALLAHVRETGGLDAVVNNAGGALGLDTVEEADLAGWRAMYELNVLGTLRVTQGVLPLLRERGEGDVVVVTSTAGQAPYPGGAGYTGVKHAERMLATTLRWEIVGEPIRVIEIAPGNVATEEFSLVRFAGDAERAAKVYAGYQPLVADDVADTIAWSLSRPAHVNVDLLVVRPRAQANNTTIARTGV
>NC_014151.1|WP_043600125.1|1598331_1600134_+|ATP-binding-cassette-domain-containing-protein
MLRLVRWARPALPRVVLGGSATLVASLIALAVPQVLRSVVNGPLLTDGSRTAVVQAALLVLVLGVLEAVLVWCRRALIATPGTGVERTMRTDLFRHLLDLPVAFHDRRGGGQLLQRSMGDLHTVRRWMVFGLVQLVVAATTVLVGAGLMLATSPPLGLVYLVGAVPVIWLGFRFRQDYKVVARRARDQAGDLATRVEESVHGIRVLKAFGRGDDALEEFVRQADELRGTELDKARAQSRMSFALAWIPETTLAVALGLGVWLAATDRVSVGALVAFFATATVMTRPVESLGHLMAMTLDARAGTDRFLDVIDTVPALADPAEPVALPAAPAGGTRVELRDVRFAHTPGSAEVLRGVDLVLEPGETMALVGLTGSGKTTLLQLVPRLYDVTGGAVLVDGVDVRDVTRHDLRGAVAVAFEDPILFSASVRDNVLMGVPTERLAEMTEQEVDDVVRIALDVASAGFVHRLPQGVDTVVGEEGMSLSGGQRQRVALARAIAGRPRVLVLDDPLSALDVATEADVTEGLRRVLAGTTTLVVAHRTSTVALADRVAVLEDGRITGVGRHADLLASHPHYRYVLTAEGDEAARPLPGDLDVAAEVGR
>NC_014151.1|WP_013116673.1|1600130_1601951_+|ABC-transporter-ATP-binding-protein
MTATTAPGRAVGSADEHDDAGPREVRRRSLGLLASLLRPVARRAGLTALVVVVAQLALVAGPALVAVGIDRGIPALRAGDATPLLLVAGGYGLTALVAGVFTAATVRLAATVSQAVLLDLRGRVFRHTQRLSLEFHERYTSGRIISRQTSDLEALRELLDGGVTTLAASGLAMTFTAVGLAVLDWRSGLVLLVAVVPGVVLTRWFQVRSQAQYRRSRTAVARVIVRFVETMTGIRAVQAFRREQQVAAVYDVEAEEYRAANAEAIRVNGVFDTGLVLIGNVTVPVVLLIGGLRVLDGALEVGVLVAAVLYARRFFAPLAQIGMFYNSFQSATAALEKLSGLLAQEPTVADPVHPVRLREPRGDVRFDGVEFGYGDGPTVLPRLDLHVPAGQTVALVGETGAGKSTVAKLLARFYDPRAGAVLLDGVDLRDVDPRDLRTAMVMVTQEAYLFSGSVGANIALGRPGASQEQIEQAARAVGVHELLASLPDGYDTDVDTRGVRLSAGQRQLVSFARAFLADPAVLVLDEATSSLDIPGEQLVQEGLRTLLTGRTAVVIAHRLSTVMHADRVLVVDGGRVVEDDSPAALVAAGGRFATLHAQWQESLRTT
>NC_014151.1|WP_013116674.1|1601969_1602575_+|nicotinamide-mononucleotide-transporter
MDWVEVVGFVTGATCVWLATRQHVANFPVGMANNLVFVVLFWQTGILANAGLQVVYLLLGGLGWWWWVRGGPDAGRLPVRRTPRLVWPLALVCAAALTVTIALVLTRTAESAQPWADAVTTSLSLVAQVMMGRKWLGSWAVWIVTDVLLVALYVTLGLYLTAALYVLFLGLCVHGWRQWSRDLRATTDVARRADVDAAAPA
>NC_014151.1|WP_013116675.1|1602571_1603624_+|AAA-family-ATPase
MTHGLVIGKFYPPHAGHLALVHAAQARCDRVTVQVLASSAESLPGEVRAAWLREELPTAHVVHGIDDHPVDYADPGAWDAHVAVIASLLDAPVDLVVTSDSYGGELARRLGARWHRVDPGRQGLPVSGTAVRADPARYWWALPAAVRAWFVRRVVVTGAESTGTTTLAQDLTAHYGLPTVAEFGREWTTARPGGLDAPWHTAEFDLVAREQARREDDAARRTPRPLLVCDTDVTATTLWHERYVGHASPTVVALAQERVPDLYLLTGDEIPFVQDGWRDGEHVRHAMQARFREELTRREAADGVPWVELRGSRTERLAAAVALVDDLLRRPRDLADPLPEANGDRATLAT
>NC_014151.1|WP_148234514.1|1603788_1605201_+|AAA-family-ATPase
MVNHAVISPHYDVEFSAPGQARTTYRLGDSRAAVHLPTDQSYSSFVLLPLLTFAVRGRCLLVGGPGRGKTASAILMGVIAGYPVRDVRRAMQHGHPQLTVQDMFGTPLPRDLVNAERLADVDVAWRSWLGMRVKIVDEYNRIPTRTQSALLTVLADGYVEVFDQVYETGASAWYLTANDDAGGGTFQVVDALRDRIDVVVKALAFNSRFLGDLVTRAERGVRPEENVPPGIVFDADEHDRLHREVLAVPLPRPVRRRLEFFAAQLELLERAGSQLEYRTKDTARLAGADPHTLLASDDGRDRRDDIGAQTLNGLSVRALQSLVLYAKAMAYFRGDAQVELDDLRAVLPFVLHDKLQPDLDAPAFDDPEREALRTDRVSWLREIFDTACLQYDAAGLDGDDPVGDVLAELAAGLDGIEEKVVLARLATIERILSGWQRTKLHGDMYDDALALKYAHQRYSSYLRWLRWQSS
>NC_014151.1|WP_148234307.1|1605185_1606115_+|hypothetical-protein
MAVVVTGVPALVRAHAATVDPWLREAAGWGVDAAAARAALTDLEPAVAALDGDPEVALPLVRATLDLLARGRWHAASVPRGVVLTVLPRLATWVRAWPADVVPAVLAASRGVARAGLLDAWVDRVARADVPAAPTDVRPALLVAAWRSGLVRYRDAALDAAAALPAATAAALLEVPEAEVGVVLERHRADRWWWPGRDDGPGVVQRVGGFVGWGGPWVQVPRVAAGGPTGWLVVVDGTVGAVVADVHGSAVVGLEDPPPTVAPPRPDARRLPVPWLDEVTGAVPGERPDVLLVARTHSCTLDVVRVAAA
>NC_014151.1|WP_013116678.1|1606111_1607860_+|VWA-domain-containing-protein
MRSRATTPDPAAQALVAAWRDAWPHALAAWGRTTRMHPPHLHTVPVADVPSFAWYDSGDVEVHVDLAHAARLGLAEHAVAVLAHEVGHHVLAPVDGRTRVRIAARVRAGLADRDDLVPLVANLWSDLLINDRLQRTGGADLAGVWRALGTPSDPLMALVLRACELLWGLPRHELCGTAVPVREEAAWLCARLVRAYARDPVAGAGGFAALVRTALADELGDAAGLAGARALACGDEASLDGLPYGVTSDDLATPVVHPAQDPAVVGDAVTAAPDVDEAVPPDGSADGTGTQHSPVLPPELHATLKALGSSATAEDVAVAWYRERAAPYLVPFRQVVQRGVPERLLAGLEPWELGEDLADVDWVGTMTASPVVVPGFTTVRRHTLEDEPVEPRRVPVDLDLYLDSSGSMADPRRFSWVALAGAVLVLSALRAGARVQATTWSGPGEVAGTDGFTRDPEAALRAVVAYIGGGTAFPLALLRRTHLGEAGQRPTAARATHIAVVSDDGARSMVPPRGLGFEPDVASRAVQAAGGGGTLLLDVPPDRLPGLVPHLPAGYDVHSVTGDEALVEFARAFARRTWGEMR
>NC_014151.1|WP_013116679.1|1607856_1608498_+|hypothetical-protein
MRDDDARLPRPLVSGERRPGPELVVVTRRLAAAPAALRDPGANAAAALADLAVVLDGRVAEAGELRSLDQRTGDPGGDRAVLALLTGWVALDPAVRADPGLQDVAKRAGGLSRLVVAAALAVAGELAELREPATWTDDEVAREELARAVLAVLGVLPAGEDPHTAGDAWRVVSTRHRRRVAAEMAAEAQRAAELAKALAEQRAKEAAAQYANY
>NC_014151.1|WP_013116680.1|1608484_1609984_+|AMP-binding-protein
MPTTDDALAGTPGRATPDPASPDRARPDPVGPPAEYAPMGALALTDHERWPSLPTADLVRVEAARQHPAAPVWVHATGDRLDTADLTALAARGRTQQSATPPDWVAALVERAHATVPRYRAAARDGRSGPSSPLHELPTVTRHDLVTDLAAHVPVDVPLDRVLQGTSSGSTGAALVVPLHPRAVAADLLLLHALVEATGTTWVADAARLGLLNLVDQRAAFTYVSAMSAFPRDPGVPAPLMARVNLDASAWRAAGDRERWLAEHDPQVVSTSTLPLVHLLDLAEAGLALHPLAVVNGATHVTPAVRRRVHDVWGAPLLDLYGLRETGPVAVAGEDAPGHVVVDRRVHVEVLDPAGRPVAPGERGEVVVTVDENPYLPLLRYRTGDHAALGSTADGRPVLLGLEGRAAVRYLDASGVARPSVDATQVLQAAGLVAWHVHQDAAGGVLLRAVAPDVLAAQAAARAVRDWLGRDVALDVLDDVADLGPGKPARWSSDVPGLG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_014151_2	2.4\|561782\|20\|NC_014151\|CRISPRCasFinder	561782-561801	20	NC_014151.1	561812-561831	0	1.0
NC_014151_2	2.4\|561782\|20\|NC_014151\|CRISPRCasFinder	561782-561801	20	NC_014151.1	561842-561861	0	1.0
NC_014151_2	2.1\|561647\|20\|NC_014151\|CRISPRCasFinder	561647-561666	20	NC_014151.1	791879-791898	2	0.9
NC_014151_2	2.1\|561647\|20\|NC_014151\|CRISPRCasFinder	561647-561666	20	NC_014151.1	2570301-2570320	2	0.9
NC_014151_2	2.1\|561647\|20\|NC_014151\|CRISPRCasFinder	561647-561666	20	NC_014151.1	2931605-2931624	2	0.9
NC_014151_2	2.1\|561647\|20\|NC_014151\|CRISPRCasFinder	561647-561666	20	NC_014151.1	3005743-3005762	2	0.9
NC_014151_2	2.4\|561782\|20\|NC_014151\|CRISPRCasFinder	561782-561801	20	NC_014151.1	3615052-3615071	2	0.9

1. spacer 2.4|561782|20|NC_014151|CRISPRCasFinder matches to position: 561812-561831, mismatch: 0, identity: 1.0

gggccgagctcgccggtgcc	CRISPR spacer
gggccgagctcgccggtgcc	Protospacer
********************

2. spacer 2.4|561782|20|NC_014151|CRISPRCasFinder matches to position: 561842-561861, mismatch: 0, identity: 1.0

gggccgagctcgccggtgcc	CRISPR spacer
gggccgagctcgccggtgcc	Protospacer
********************

3. spacer 2.1|561647|20|NC_014151|CRISPRCasFinder matches to position: 791879-791898, mismatch: 2, identity: 0.9

cgcgggacctgcgcgacgcc	CRISPR spacer
cgcgggatctgcgcgtcgcc	Protospacer
*******.******* ****

4. spacer 2.1|561647|20|NC_014151|CRISPRCasFinder matches to position: 2570301-2570320, mismatch: 2, identity: 0.9

cgcgggacctgcgcgacgcc	CRISPR spacer
cgcgcgacctgcgcgtcgcc	Protospacer
**** ********** ****

5. spacer 2.1|561647|20|NC_014151|CRISPRCasFinder matches to position: 2931605-2931624, mismatch: 2, identity: 0.9

cgcgggacctgcgcgacgcc	CRISPR spacer
cgcgcgacctgctcgacgcc	Protospacer
**** ******* *******

6. spacer 2.1|561647|20|NC_014151|CRISPRCasFinder matches to position: 3005743-3005762, mismatch: 2, identity: 0.9

cgcgggacctgcgcgacgcc	CRISPR spacer
cgcggggcctgagcgacgcc	Protospacer
******.**** ********

7. spacer 2.4|561782|20|NC_014151|CRISPRCasFinder matches to position: 3615052-3615071, mismatch: 2, identity: 0.9

gggccgagctcgccggtgcc	CRISPR spacer
gggccgagctcgtcggggcc	Protospacer
************.*** ***

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014151_2	2.1\|561647\|20\|NC_014151\|CRISPRCasFinder	561647-561666	20	NZ_CP032325	Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence	471445-471464	1	0.95
NC_014151_2	2.1\|561647\|20\|NC_014151\|CRISPRCasFinder	561647-561666	20	NZ_CP007796	Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence	205560-205579	1	0.95
NC_014151_2	2.1\|561647\|20\|NC_014151\|CRISPRCasFinder	561647-561666	20	NC_008697	Nocardioides sp. JS614 plasmid pNOCA01, complete sequence	124320-124339	1	0.95
NC_014151_1	1.1\|493353\|26\|NC_014151\|CRISPRCasFinder	493353-493378	26	KT997862	Uncultured Mediterranean phage uvDeep-CGR2-KM21-C88, complete genome	4858-4883	4	0.846
NC_014151_1	1.1\|493353\|26\|NC_014151\|CRISPRCasFinder	493353-493378	26	MF417917	Uncultured Caudovirales phage clone 7F_10, partial genome	37212-37237	5	0.808
NC_014151_1	1.1\|493353\|26\|NC_014151\|CRISPRCasFinder	493353-493378	26	CP037991	Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence	107057-107082	5	0.808

1. spacer 2.1|561647|20|NC_014151|CRISPRCasFinder matches to NZ_CP032325 (Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence) position: , mismatch: 1, identity: 0.95

cgcgggacctgcgcgacgcc	CRISPR spacer
tgcgggacctgcgcgacgcc	Protospacer
.*******************

2. spacer 2.1|561647|20|NC_014151|CRISPRCasFinder matches to NZ_CP007796 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence) position: , mismatch: 1, identity: 0.95

cgcgggacctgcgcgacgcc	CRISPR spacer
tgcgggacctgcgcgacgcc	Protospacer
.*******************

3. spacer 2.1|561647|20|NC_014151|CRISPRCasFinder matches to NC_008697 (Nocardioides sp. JS614 plasmid pNOCA01, complete sequence) position: , mismatch: 1, identity: 0.95

cgcgggacctgcgcgacgcc	CRISPR spacer
ggcgggacctgcgcgacgcc	Protospacer
 *******************

4. spacer 1.1|493353|26|NC_014151|CRISPRCasFinder matches to KT997862 (Uncultured Mediterranean phage uvDeep-CGR2-KM21-C88, complete genome) position: , mismatch: 4, identity: 0.846

acgggggagtgggggtggggtggggc	CRISPR spacer
aggggggcgtgggggtggggtgggct	Protospacer
* ***** **************** .

5. spacer 1.1|493353|26|NC_014151|CRISPRCasFinder matches to MF417917 (Uncultured Caudovirales phage clone 7F_10, partial genome) position: , mismatch: 5, identity: 0.808

acgggggagtgggggtggggtggggc	CRISPR spacer
gtgggggggggggggtggggtggggg	Protospacer
..*****.* ***************

6. spacer 1.1|493353|26|NC_014151|CRISPRCasFinder matches to CP037991 (Bacillus mycoides strain TH26 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.808

acgggggagtgggggtggggtggggc	CRISPR spacer
gggggggagtgggggggggggggggg	Protospacer
. ************* **** ****

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage